{"IPR000001": {"description": "Kringle", "go_ids": [], "go_terms": [], "name": "Kringle", "pathway_ids": ["R-HSA-186797", "R-HSA-6798695", "R-MMU-416476", "R-HSA-8874081", "R-HSA-8875555", "R-HSA-159782", "R-MMU-159740", "R-MMU-76009", "R-MMU-6811558", "R-HSA-140837", "R-RNO-140875", "R-BTA-6798695", "R-MMU-8875791", "R-MMU-375276", "R-RNO-3772470", "R-CFA-9734091", "R-MMU-8865999", "R-CFA-114608", "R-HSA-6806942", "R-RNO-140837", "R-RNO-977606", "R-CFA-1257604", "R-MMU-456926", "R-CFA-8851805", "R-RNO-6811558", "R-MMU-8851805", "R-RNO-202733", "R-CFA-6807004", "R-MMU-202733", "R-CFA-5673001", "R-HSA-9672391", "R-HSA-8875513", "R-CFA-186797", "R-HSA-5140745", "R-CFA-8851907", "R-RNO-8865999", "R-HSA-75205", "R-HSA-1266695", "R-HSA-381426", "R-RNO-5673001", "R-RNO-159740", "R-RNO-416476", "R-MMU-5673001", "R-HSA-1474228", "R-RNO-6806942", "R-MMU-1592389", "R-CFA-8874081", "R-HSA-456926", "R-DME-5140745", "R-RNO-159763", "R-MMU-140837", "R-CFA-8875513", "R-HSA-2219530", "R-HSA-6785807", 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"R-MMU-75205", "R-HSA-1592389", "R-HSA-6807004", "R-MMU-1257604", "R-SSC-75205", "R-HSA-140875", "R-HSA-8964041", "R-MMU-140875", "R-RNO-6807004", "R-MMU-6806942", "R-CFA-8865999", "R-RNO-375276", "R-MMU-159782", "R-MMU-8851907", "R-CFA-75205", "R-BTA-75205", "R-MMU-8875656", "R-MMU-6807004", "R-HSA-8875656", "R-HSA-202733", "R-SSC-186797"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-8875791:r:MET activates STAT3", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-CFA-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-8865999:r:MET activates PTPN11", "R-CFA-114608:r:Platelet degranulation", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-977606:r:Regulation of Complement cascade", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CFA-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CFA-6807004:r:Negative regulation of MET activity", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-CFA-186797:r:Signaling by PDGF", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-CFA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-8865999:r:MET activates PTPN11", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-6806942:r:MET Receptor Activation", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-CFA-8874081:r:MET activates PTK2 signaling", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-CFA-8875513:r:MET interacts with TNS proteins", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-CFA-8875555:r:MET activates RAP1 and RAC1", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-8851805:r:MET activates RAS signaling", "R-CFA-6806942:r:MET Receptor Activation", "R-CFA-8875656:r:MET receptor recycling", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-186797:r:Signaling by PDGF", "R-HSA-8865999:r:MET activates PTPN11", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-114608:r:Platelet degranulation", "R-CFA-8875791:r:MET activates STAT3", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-8852405:r:Signaling by MST1", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-8852405:r:Signaling by MST1", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-8875791:r:MET activates STAT3", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-HSA-4086400:r:PCP/CE pathway", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SSC-75205:r:Dissolution of Fibrin Clot", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-8964041:r:LDL remodeling", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-6806942:r:MET Receptor Activation", "R-CFA-8865999:r:MET activates PTPN11", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-75205:r:Dissolution of Fibrin Clot", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-8875656:r:MET receptor recycling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-SSC-186797:r:Signaling by PDGF"], "type": "Domain"}, "IPR000006": {"description": "Metallothionein, vertebrate", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Metalthion_vert", "pathway_ids": ["R-RNO-5661231", "R-SSC-5661231", "R-HSA-5661231", "R-GGA-5661231", "R-MMU-5661231", "R-HSA-877300", "R-DRE-5661231", "R-BTA-5661231"], "pathways": ["R-RNO-5661231:r:Metallothioneins bind metals", "R-SSC-5661231:r:Metallothioneins bind metals", "R-HSA-5661231:r:Metallothioneins bind metals", "R-GGA-5661231:r:Metallothioneins bind metals", "R-MMU-5661231:r:Metallothioneins bind metals", "R-HSA-877300:r:Interferon gamma signaling", "R-DRE-5661231:r:Metallothioneins bind metals", "R-BTA-5661231:r:Metallothioneins bind metals"], "type": "Family"}, "IPR000007": {"description": "Tubby, C-terminal", "go_ids": [], "go_terms": [], "name": "Tubby_C", "pathway_ids": ["R-MMU-8951664", "R-CEL-5610787", "R-HSA-5610787", "R-MMU-5610787", "R-HSA-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-CEL-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-8951664:r:Neddylation"], "type": "Domain"}, "IPR000008": {"description": "C2 domain", "go_ids": [], "go_terms": [], "name": "C2_dom", "pathway_ids": ["R-SCE-114516", "R-DDI-1257604", "R-SPO-4419969", "R-DRE-5625740", "R-XTR-111995", "R-HSA-2142753", "R-DRE-4419969", "R-HSA-983168", "R-DRE-1482922", "R-MMU-1169408", "R-HSA-186763", "R-BTA-8856825", "R-HSA-111995", "R-DME-3000170", "R-RNO-2424491", "R-RNO-1169091", "R-SCE-114508", "R-BTA-9020702", "R-HSA-9692916", "R-BTA-4419969", "R-MMU-3928662", "R-CEL-399997", "R-HSA-9013406", "R-BTA-418217", "R-HSA-202424", "R-DME-9013423", "R-RNO-2871837", "R-MMU-2173795", "R-XTR-76005", "R-SCE-399997", "R-HSA-9020702", "R-RNO-8948751", "R-DRE-1169091", "R-HSA-168638", "R-MMU-8941858", "R-RNO-111995", "R-MMU-114604", "R-CEL-1660514", "R-DME-2173788", "R-HSA-167021", "R-DME-5658442", "R-RNO-202433", "R-CEL-114516", "R-DDI-2179392", "R-MMU-9020702", "R-MMU-9013409", 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"R-RNO-4419969", "R-SPO-8948751", "R-RNO-983168", "R-HSA-9679504", "R-MMU-2028269", "R-HSA-114516", "R-DME-2122948", "R-DME-1169091", "R-GGA-418592", "R-MMU-8856825", "R-MMU-432722", "R-RNO-111933", "R-DDI-8849471", "R-DDI-198323", "R-HSA-936440", "R-BTA-114516", "R-HSA-1169408", "R-HSA-399997", "R-CEL-9013149", "R-DME-888590", "R-XTR-5620912", "R-SCE-9634635", "R-HSA-112043", "R-SCE-9013406", "R-BTA-212676", "R-DRE-1482839", "R-RNO-5625886", "R-SPO-114604", "R-SPO-983168", "R-DDI-389513", "R-MMU-1855183", "R-RNO-373752", "R-MMU-1482925", "R-RNO-9648002", "R-MMU-1855204", "R-DDI-1169408", "R-XTR-1482839", "R-DME-8856825", "R-DRE-5689880", "R-HSA-9013420", "R-HSA-9013508", "R-HSA-9679191", "R-MMU-983695", "R-HSA-1433557", "R-MMU-877300", "R-CEL-418594", "R-SPO-203615", "R-RNO-114604", "R-HSA-418594", "R-BTA-5218921", "R-GGA-2142753", "R-MMU-2871809", "R-RNO-5658442", "R-MMU-9013026", "R-DDI-434316", "R-MMU-983168", "R-DDI-389357", "R-MMU-4419969", "R-RNO-1250196", "R-RNO-888590", "R-DRE-6811436", "R-MMU-9026527", "R-MMU-8856828", "R-RNO-418592", "R-DDI-114516", "R-BTA-1483115", "R-BTA-5625886", "R-CEL-181430", "R-RNO-9013409", "R-MMU-9668328", "R-GGA-181429", "R-SCE-9841251", "R-MMU-8948751", "R-DME-8948751", "R-DRE-8941858", "R-SCE-198323", "R-DDI-1855204", "R-XTR-1483115", "R-BTA-1169091", "R-DDI-983695", "R-DDI-2029485", "R-DME-2029485", "R-HSA-9013507", "R-RNO-193648", "R-MMU-186763", "R-DDI-9634635", "R-MMU-9035034", "R-HSA-983695", "R-BTA-5099900", "R-DME-5625886", "R-MMU-8948747", "R-RNO-9013148", "R-SCE-1474151", "R-CEL-212676", "R-XTR-1482798", "R-MMU-4641258", "R-BTA-6811436", "R-DDI-5674135", "R-MMU-5654219", "R-SPO-9841251", "R-HSA-1482839", "R-HSA-1855204", "R-MMU-399997", "R-DRE-9013026", "R-BTA-8980692", "R-CEL-8948751", "R-HSA-9680350", "R-MMU-5654227", "R-SCE-114604", "R-DDI-9009391", "R-RNO-8980692", "R-HSA-5625740", "R-DRE-4641257", "R-CEL-2179392", "R-RNO-1489509", "R-HSA-1482925", "R-HSA-5625886", "R-SPO-5625740", "R-DRE-983168", "R-BTA-4086398", "R-RNO-416482", "R-HSA-2173795", "R-BTA-76005", "R-RNO-3928662", "R-MMU-201451", "R-BTA-1483166", "R-CEL-9013406", "R-HSA-1483115", "R-SPO-399997", "R-SCE-9031628", "R-MMU-114508", "R-GGA-264642", "R-CEL-8856828", "R-HSA-3000170", "R-HSA-5655332", "R-GGA-8856825", "R-SPO-5628897", "R-RNO-210500", "R-SCE-9009391", "R-HSA-5099900", "R-BTA-399997", "R-HSA-2871809", "R-DDI-112043", "R-DME-8939236", "R-DME-2173795", "R-DDI-9648002", "R-DDI-5675221", "R-CEL-2672351", "R-HSA-9725371", "R-HSA-8856825", "R-DDI-450385", "R-RNO-983695", "R-RNO-5654227", "R-RNO-166016", "R-SCE-198693", "R-CEL-114604", "R-HSA-2173788", "R-RNO-416993", "R-DME-5689880", "R-MMU-1253288", "R-XTR-6811436", "R-RNO-877300", "R-MMU-1433559", "R-MMU-111995", "R-RNO-1483166", "R-MMU-9013106", "R-HSA-8856828", "R-HSA-166016", "R-RNO-5621480", "R-MMU-5099900", "R-CEL-5099900", "R-HSA-5654228", "R-CEL-432722", "R-CEL-4419969", "R-MMU-5625740", "R-MMU-2122948", "R-SPO-202424", "R-DDI-6804757", "R-CEL-1169091", "R-XTR-5099900", "R-DRE-6798695", "R-CEL-5654228", "R-HSA-1855183", "R-MMU-1482798", "R-DDI-9013423", "R-RNO-9013408", "R-DRE-76005", "R-DME-4608870", "R-GGA-1482922", "R-DRE-5668599", "R-GGA-8856828", "R-HSA-212718", "R-MMU-1433557", "R-DRE-1482798", "R-SPO-165158", "R-DRE-416993", "R-HSA-9034793", "R-HSA-450520", "R-HSA-5250989", "R-BTA-1482925", "R-SPO-5218920", "R-HSA-4641258", "R-DDI-203615", "R-XTR-5218921", "R-HSA-5218921", "R-SPO-8980692", "R-BTA-5668599", "R-HSA-4419969", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-9013406", "R-MMU-6798695", "R-CEL-186763", "R-DDI-9031628", "R-MMU-2173788", "R-DDI-1489509", "R-MMU-1660517", "R-RNO-432142", "R-MMU-114608", "R-MMU-5610780", "R-HSA-1660517", "R-BTA-210500", "R-SCE-1855204", "R-XTR-1482922", "R-GGA-1482801", "R-BTA-1482788", "R-DDI-6811558", "R-SPO-1474151", "R-RNO-450520", "R-XTR-1483166", "R-HSA-1660499", "R-RNO-1660514", "R-DME-264642", "R-GGA-1855204", "R-RNO-5668599", "R-HSA-2871837", "R-HSA-210990", "R-RNO-1660516", "R-HSA-5610787", "R-DME-9013406", "R-DRE-9013149", "R-DRE-2142753", "R-CEL-181429", "R-RNO-114508", "R-HSA-432722", "R-DDI-198693", "R-HSA-445355", "R-HSA-2173791", "R-MMU-888590", "R-RNO-76005", "R-HSA-1660514", "R-RNO-5654221", "R-HSA-5632684", "R-HSA-9824585", "R-HSA-5654227", "R-HSA-888590", "R-MMU-1482922", "R-CEL-1169408", "R-RNO-5607764", "R-SPO-6804758", "R-HSA-9845576", "R-MMU-416482", "R-DME-114516", "R-RNO-1855204", "R-MMU-1482801", "R-SCE-202424", "R-HSA-9013409", "R-SPO-2029485", "R-BTA-112043", "R-HSA-5689880", "R-RNO-1474228", "R-MMU-4086398", "R-SPO-389357", "R-HSA-1489509", "R-MMU-9013408", "R-MMU-210990", "R-DDI-416476", "R-RNO-1433559", "R-DME-5218921", "R-MMU-8854214", "R-CEL-888590", "R-RNO-111465", "R-DDI-5213460", "R-SCE-6804757", "R-HSA-8853659", "R-MMU-9013420", "R-SPO-5668599", "R-DDI-5218920", "R-MMU-1482788", "R-DDI-5673000", "R-CEL-3000170", "R-MMU-5620912", "R-HSA-210500", "R-SPO-392451", "R-RNO-212718", "R-BTA-5625740", "R-HSA-9026527", "R-BTA-181430", "R-HSA-181430", "R-SPO-9031628", "R-HSA-434316", "R-RNO-1855183", "R-HSA-2424491", "R-HSA-416482", "R-BTA-1482839", "R-HSA-5637810", "R-HSA-9696264", "R-RNO-6811436", "R-MMU-1483166", "R-HSA-1445148", "R-HSA-111933", "R-MMU-193648", "R-CEL-1660517", "R-HSA-9013026", "R-DDI-202433", "R-XTR-9020702", "R-DME-201451", "R-CEL-8856825", "R-HSA-212676", "R-HSA-9664323", "R-HSA-1839117", "R-DME-983168", "R-HSA-5655253", "R-DDI-165159", "R-GGA-1482788", "R-HSA-8854214", "R-MMU-8980692", "R-CEL-1489509", "R-RNO-1169408", "R-SCE-6798695", "R-XTR-432142", "R-HSA-2029485", "R-HSA-9013106", "R-DME-114508", "R-SPO-5218921", "R-GGA-1482925", "R-CEL-5607764", "R-CEL-983168", "R-RNO-399997", "R-SCE-6804758", "R-MMU-8939236", "R-HSA-9013423", "R-MMU-1483206", "R-DRE-1483115", "R-DME-416476", "R-SPO-9013420", "R-HSA-1250196", "R-HSA-4086398", "R-SPO-6804757", "R-SPO-198693", "R-MMU-202424", "R-SCE-5625740", "R-BTA-8856828", "R-HSA-381038", "R-RNO-8849471", "R-HSA-5655291", "R-MMU-212676", "R-MMU-1169091", "R-MMU-1660499", "R-HSA-1482801", "R-RNO-9856530", "R-SCE-392451", "R-HSA-5654219", "R-MMU-212718", "R-HSA-201556", "R-SPO-199418", "R-HSA-111465", "R-HSA-8939236", "R-SCE-5218920", "R-HSA-422356", "R-MMU-5607764", "R-XTR-418592", "R-DDI-1483206", "R-SCE-450385", "R-HSA-8849471", "R-SPO-9013106", "R-SCE-5607764", "R-CEL-114508", "R-CEL-1433559", "R-HSA-4641257", "R-MMU-5668599", "R-RNO-202424", "R-MMU-1660514", "R-SCE-9013420", "R-BTA-1482798", "R-RNO-9013406", "R-HSA-5621480", "R-CEL-9013148", "R-HSA-5655302", "R-SCE-9856530", "R-RNO-201556", "R-HSA-9665686", "R-SPO-5607764", "R-RNO-8853659", "R-MMU-166016", "R-RNO-1483115", "R-DME-9668328", "R-HSA-9755511", "R-DME-2173791", "R-MMU-111933", "R-MMU-6811436", "R-BTA-416476", "R-DME-399997", "R-HSA-9013149", "R-BTA-1855204", "R-HSA-1169091", "R-HSA-8980692", "R-HSA-5658442", "R-SPO-389513", "R-DME-181430", "R-HSA-1253288", "R-HSA-8948751", "R-HSA-418890", "R-RNO-181429", "R-SPO-2179392", "R-BTA-9013106", "R-SCE-202433", "R-SPO-1489509", "R-HSA-2122948", "R-HSA-416476", "R-MMU-9845576", "R-MMU-1483115", "R-DDI-9013149", "R-SCE-1169091", "R-SCE-8948751", "R-HSA-1236382", "R-RNO-9845576", "R-SCE-1257604", "R-DME-8856828", "R-MMU-5625886", "R-RNO-9013106", "R-DRE-9856530", "R-DME-181429", "R-RNO-5099900", "R-SPO-1257604", "R-HSA-5620912", "R-HSA-5607764", "R-DME-1489509", "R-MMU-5654228", "R-DME-4419969", "R-RNO-8948747", "R-MMU-416993", "R-HSA-193648", "R-GGA-6811436", "R-MMU-202433", "R-SSC-1855204", "R-MMU-181429", "R-GGA-432142", "R-DME-212676", "R-MMU-418592", "R-RNO-5218921", "R-XTR-1482788", "R-DME-5632684", "R-DDI-5607764", "R-CEL-1660499", "R-DDI-114508", "R-DRE-1482801", "R-MMU-2424491", "R-SCE-5668599", "R-HSA-8939246", "R-RNO-186763", "R-HSA-2028269", "R-HSA-9696273", "R-SCE-2871837", "R-XTR-1169091", "R-RNO-9013026", "R-HSA-9013405", "R-DDI-114604", "R-XTR-1482801", "R-HSA-8936459", "R-HSA-2871796", "R-BTA-1483206", "R-MMU-1632852", "R-MMU-181430", "R-SPO-165181", "R-HSA-9010642", "R-CEL-5654219", "R-RNO-2871809", "R-HSA-9668328", "R-MMU-5654221", "R-DDI-202424", "R-MMU-5689880", "R-MMU-201556", "R-HSA-76005", "R-HSA-432040", "R-SCE-8980692", "R-HSA-9662360", "R-MMU-5610787", "R-DRE-201451", "R-RNO-416476", "R-SCE-165158", "R-SCE-9696273", "R-DDI-399997", "R-DDI-6798695", "R-DME-4641257", "R-SPO-6811558", "R-MMU-112043", "R-HSA-373752", "R-HSA-162588", "R-GGA-1483166", "R-BTA-500657", "R-SCE-1489509", "R-CEL-112043", "R-DME-112043", "R-RNO-5654228", "R-DRE-8980692", "R-XTR-2142753", "R-SCE-389513", "R-MMU-1250196", "R-RNO-1483206", "R-RNO-2871796", "R-HSA-202433", "R-MMU-2142753", "R-HSA-201451", "R-CEL-210500", "R-DME-111933", "R-XTR-4419969", "R-CEL-5654227", "R-SCE-76005", "R-DME-2028269", "R-MMU-9034793", "R-HSA-114608", "R-SPO-114516", "R-HSA-500657", "R-MMU-2672351", "R-CEL-5654221", "R-HSA-9013148", "R-RNO-8856828", "R-HSA-1483206", "R-SCE-4419969", "R-MMU-5621480", "R-RNO-434316", "R-HSA-6811436", "R-DDI-5628897", "R-DDI-1474151", "R-MMU-114516", "R-DME-2179392", "R-DRE-111995", "R-MMU-5675482", "R-DRE-2173788", "R-MMU-210500", "R-HSA-1482798", "R-BTA-416482", "R-RNO-9013423", "R-GGA-888590", "R-HSA-9717207", "R-SPO-2871837", "R-DDI-4419969", "R-CEL-5218921", "R-HSA-9027277", "R-BTA-1482922", "R-BTA-181429", "R-HSA-9725370", "R-DRE-418592", "R-HSA-5668599", "R-SPO-202433", "R-CEL-2029485", "R-MMU-416476", "R-HSA-6798695", "R-DDI-5218921", "R-MMU-5632684", "R-RNO-9020702", "R-MMU-1660516", "R-CEL-6798695", "R-MMU-2173791", "R-BTA-1482801", "R-BTA-6798695", "R-CEL-9013409", "R-SCE-389357", "R-SPO-76005", "R-SPO-1855204", "R-SPO-198323", "R-MMU-432142", "R-SCE-6811558", "R-DDI-5675482", "R-RNO-212676", "R-SPO-9009391", "R-DDI-9841251", "R-DME-8948747", "R-MMU-2029485", "R-RNO-9013404", "R-CEL-9668328", "R-HSA-9013408", "R-MMU-434316", "R-HSA-5654221", "R-RNO-1482839", "R-RNO-1482801", "R-DRE-5099900", "R-MMU-1474228", "R-DDI-8948751", "R-HSA-5675482", "R-RNO-1482922", "R-HSA-264642", "R-DRE-1482925", "R-DME-450520", "R-XTR-6798695", "R-HSA-1660516", "R-RNO-1433557", "R-CEL-212718", "R-MMU-418217", "R-DDI-9856530", "R-DME-1250196", "R-MMU-76005", "R-DDI-5625740", "R-HSA-1632852", "R-DME-76005", "R-RNO-9668328", "R-DME-8941858", "R-SPO-6798695", "R-MMU-2179392", "R-DME-416993", "R-RNO-114516", "R-MMU-9856530", "R-MMU-9648002", "R-BTA-416993", "R-DDI-2871837", "R-MMU-9013148", "R-HSA-1251932", "R-CEL-416476", "R-XTR-5668599", "R-HSA-6794361", "R-DDI-76005", "R-RNO-114608", "R-HSA-9754560", "R-HSA-1482922", "R-HSA-114508", "R-DDI-1169091", "R-MMU-9824585", "R-HSA-9035034", "R-DME-9013409", "R-MMU-5658442", "R-MMU-168638", "R-SCE-983168", "R-MMU-4608870", "R-MMU-5218921", "R-SPO-9856530", "R-HSA-9694676", "R-CEL-202433", "R-RNO-8856825", "R-DDI-3295583", "R-RNO-9034793", "R-MMU-500657", "R-BTA-434316", "R-RNO-2142753"], "pathways": ["R-SCE-114516:r:Disinhibition of SNARE formation", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-XTR-111995:r:phospho-PLA2 pathway", "R-HSA-2142753:r:Arachidonate metabolism", "R-DRE-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-1482922:r:Acyl chain remodelling of PI", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-186763:r:Downstream signal transduction", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-111995:r:phospho-PLA2 pathway", "R-DME-3000170:r:Syndecan interactions", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-114508:r:Effects of PIP2 hydrolysis", "R-BTA-9020702:r:Interleukin-1 signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "R-HSA-202424:r:Downstream TCR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-XTR-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SCE-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-111995:r:phospho-PLA2 pathway", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-RNO-202433:r:Generation of second messenger molecules", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-DDI-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-3000170:r:Syndecan interactions", "R-DME-9013148:r:CDC42 GTPase cycle", "R-XTR-114516:r:Disinhibition of SNARE formation", "R-RNO-210990:r:PECAM1 interactions", "R-DME-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-1489509:r:DAG and IP3 signaling", "R-SPO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-GGA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-GGA-1483115:r:Hydrolysis of LPC", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-RNO-112043:r:PLC beta mediated events", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-DRE-1483166:r:Synthesis of PA", "R-HSA-1433559:r:Regulation of KIT signaling", "R-CEL-418597:r:G alpha (z) signalling events", "R-HSA-418597:r:G alpha (z) signalling events", "R-BTA-2142753:r:Arachidonate metabolism", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-9648002:r:RAS processing", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-9035034:r:RHOF GTPase cycle", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-GGA-1482798:r:Acyl chain remodeling of CL", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-HSA-1483166:r:Synthesis of PA", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-GGA-111995:r:phospho-PLA2 pathway", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-CEL-111933:r:Calmodulin induced events", "R-RNO-1482925:r:Acyl chain remodelling of PG", "R-GGA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DRE-114516:r:Disinhibition of SNARE formation", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-SPO-114508:r:Effects of PIP2 hydrolysis", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SPO-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-9013106:r:RHOC GTPase cycle", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-XTR-1482925:r:Acyl chain 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cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-5250958:r:Toxicity of botulinum toxin type B (botB)", "R-SCE-203615:r:eNOS activation", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-SPO-8948751:r:Regulation of PTEN stability and activity", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-MMU-2028269:r:Signaling by Hippo", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-111933:r:Calmodulin induced events", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DDI-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-114516:r:Disinhibition of SNARE formation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SCE-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-112043:r:PLC beta mediated events", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DRE-1482839:r:Acyl chain remodelling of PE", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SPO-114604:r:GPVI-mediated activation cascade", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-373752:r:Netrin-1 signaling", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-RNO-9648002:r:RAS processing", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-XTR-1482839:r:Acyl chain remodelling of PE", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-877300:r:Interferon gamma signaling", "R-CEL-418594:r:G alpha (i) signalling events", "R-SPO-203615:r:eNOS activation", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-418594:r:G alpha (i) signalling events", "R-BTA-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-2142753:r:Arachidonate metabolism", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DDI-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-BTA-1483115:r:Hydrolysis of LPC", "R-BTA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-GGA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-SCE-198323:r:AKT phosphorylates targets in the cytosol", "R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-XTR-1483115:r:Hydrolysis of LPC", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-DME-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-8948747:r:Regulation of PTEN localization", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-XTR-1482798:r:Acyl chain remodeling of CL", "R-MMU-4641258:r:Degradation of DVL", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-SCE-114604:r:GPVI-mediated activation cascade", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-DRE-4641257:r:Degradation of AXIN", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-1489509:r:DAG and IP3 signaling", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-201451:r:Signaling by BMP", "R-BTA-1483166:r:Synthesis of PA", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-1483115:r:Hydrolysis of LPC", "R-SPO-399997:r:Acetylcholine regulates insulin secretion", "R-SCE-9031628:r:NGF-stimulated transcription", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-GGA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-112043:r:PLC beta mediated events", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DDI-9648002:r:RAS processing", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-SCE-198693:r:AKT phosphorylates targets in the nucleus", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-XTR-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-877300:r:Interferon gamma signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-MMU-111995:r:phospho-PLA2 pathway", "R-RNO-1483166:r:Synthesis of PA", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-5621480:r:Dectin-2 family", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-SPO-202424:r:Downstream TCR signaling", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-CEL-1169091:r:Activation of NF-kappaB in B cells", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-DRE-6798695:r:Neutrophil degranulation", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DRE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-GGA-1482922:r:Acyl chain remodelling of PI", "R-DRE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-DRE-1482798:r:Acyl chain remodeling of CL", "R-SPO-165158:r:Activation of AKT2", "R-DRE-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-5250989:r:Toxicity of botulinum toxin type G (botG)", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-4641258:r:Degradation of DVL", "R-DDI-203615:r:eNOS activation", "R-XTR-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-DDI-9031628:r:NGF-stimulated transcription", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DDI-1489509:r:DAG and IP3 signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-432142:r:Platelet sensitization by LDL", "R-MMU-114608:r:Platelet degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-XTR-1482922:r:Acyl chain remodelling of PI", "R-GGA-1482801:r:Acyl chain remodelling of PS", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-GGA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DRE-2142753:r:Arachidonate metabolism", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9845576:r:Glycosphingolipid transport", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-DME-114516:r:Disinhibition of SNARE formation", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-SCE-202424:r:Downstream TCR signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-112043:r:PLC beta mediated events", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-4086398:r:Ca2+ pathway", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-DDI-416476:r:G alpha (q) signalling events", "R-RNO-1433559:r:Regulation of KIT signaling", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-8854214:r:TBC/RABGAPs", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-HSA-8853659:r:RET signaling", "R-MMU-9013420:r:RHOU GTPase cycle", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-DDI-5673000:r:RAF activation", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SPO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SPO-9031628:r:NGF-stimulated transcription", "R-HSA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-111933:r:Calmodulin induced events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DDI-202433:r:Generation of second messenger molecules", "R-XTR-9020702:r:Interleukin-1 signaling", "R-DME-201451:r:Signaling by BMP", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DDI-165159:r:MTOR signalling", "R-GGA-1482788:r:Acyl chain remodelling of PC", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-1489509:r:DAG and IP3 signaling", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-SCE-6798695:r:Neutrophil degranulation", "R-XTR-432142:r:Platelet sensitization by LDL", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-1482925:r:Acyl chain remodelling of PG", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-DRE-1483115:r:Hydrolysis of LPC", "R-DME-416476:r:G alpha (q) signalling events", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-4086398:r:Ca2+ pathway", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-198693:r:AKT phosphorylates targets in the nucleus", "R-MMU-202424:r:Downstream TCR signaling", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-201556:r:Signaling by ALK", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-422356:r:Regulation of insulin secretion", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DDI-1483206:r:Glycerophospholipid biosynthesis", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-SPO-9013106:r:RHOC GTPase cycle", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-CEL-1433559:r:Regulation of KIT signaling", "R-HSA-4641257:r:Degradation of AXIN", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-9013420:r:RHOU GTPase cycle", "R-BTA-1482798:r:Acyl chain remodeling of CL", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-5621480:r:Dectin-2 family", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-201556:r:Signaling by ALK", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-1483115:r:Hydrolysis of LPC", "R-DME-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-111933:r:Calmodulin induced events", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-416476:r:G alpha (q) signalling events", "R-DME-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-DME-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-2179392:r:EGFR Transactivation by Gastrin", "R-BTA-9013106:r:RHOC GTPase cycle", "R-SCE-202433:r:Generation of second messenger molecules", "R-SPO-1489509:r:DAG and IP3 signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-9845576:r:Glycosphingolipid transport", "R-MMU-1483115:r:Hydrolysis of LPC", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-SCE-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-9845576:r:Glycosphingolipid transport", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-9013106:r:RHOC GTPase cycle", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-1489509:r:DAG and IP3 signaling", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-8948747:r:Regulation of PTEN localization", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-193648:r:NRAGE signals death through JNK", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-202433:r:Generation of second messenger molecules", "R-SSC-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-GGA-432142:r:Platelet sensitization by LDL", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-XTR-1482788:r:Acyl chain remodelling of PC", "R-DME-5632684:r:Hedgehog 'on' state", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-DRE-1482801:r:Acyl chain remodelling of PS", "R-MMU-2424491:r:DAP12 signaling", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-9696273:r:RND1 GTPase cycle", "R-SCE-2871837:r:FCERI mediated NF-kB activation", "R-XTR-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-XTR-1482801:r:Acyl chain remodelling of PS", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-BTA-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-1632852:r:Macroautophagy", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DDI-202424:r:Downstream TCR signaling", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-201556:r:Signaling by ALK", "R-HSA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DRE-201451:r:Signaling by BMP", "R-RNO-416476:r:G alpha (q) signalling events", "R-SCE-165158:r:Activation of AKT2", "R-SCE-9696273:r:RND1 GTPase cycle", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-112043:r:PLC beta mediated events", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-GGA-1483166:r:Synthesis of PA", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-SCE-1489509:r:DAG and IP3 signaling", "R-CEL-112043:r:PLC beta mediated events", "R-DME-112043:r:PLC beta mediated events", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DRE-8980692:r:RHOA GTPase cycle", "R-XTR-2142753:r:Arachidonate metabolism", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-1483206:r:Glycerophospholipid biosynthesis", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-HSA-202433:r:Generation of second messenger molecules", "R-MMU-2142753:r:Arachidonate metabolism", "R-HSA-201451:r:Signaling by BMP", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-111933:r:Calmodulin induced events", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-SCE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DME-2028269:r:Signaling by Hippo", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-114608:r:Platelet degranulation", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-MMU-2672351:r:Stimuli-sensing channels", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-5621480:r:Dectin-2 family", "R-RNO-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-111995:r:phospho-PLA2 pathway", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-GGA-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-SPO-2871837:r:FCERI mediated NF-kB activation", "R-DDI-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SPO-202433:r:Generation of second messenger molecules", "R-CEL-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-432142:r:Platelet sensitization by LDL", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-8948747:r:Regulation of PTEN localization", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-CEL-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-RNO-1482801:r:Acyl chain remodelling of PS", "R-DRE-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-RNO-1482922:r:Acyl chain remodelling of PI", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DRE-1482925:r:Acyl chain remodelling of PG", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-XTR-6798695:r:Neutrophil degranulation", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DDI-5625740:r:RHO GTPases activate PKNs", "R-HSA-1632852:r:Macroautophagy", "R-DME-76005:r:Response to elevated platelet cytosolic Ca2+", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-114516:r:Disinhibition of SNARE formation", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9648002:r:RAS processing", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DDI-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-CEL-416476:r:G alpha (q) signalling events", "R-XTR-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DDI-76005:r:Response to elevated platelet cytosolic Ca2+", "R-RNO-114608:r:Platelet degranulation", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-DDI-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-CEL-202433:r:Generation of second messenger molecules", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-3295583:r:TRP channels", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-BTA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-RNO-2142753:r:Arachidonate metabolism"], "type": "Domain"}, "IPR000009": {"description": "Protein phosphatase 2A regulatory subunit PR55", "go_ids": ["GO:0000159", "GO:0019888"], "go_terms": ["GO:0000159:protein phosphatase type 2A complex:C", "GO:0019888:protein phosphatase regulator activity:F"], "name": "PP2A_PR55", "pathway_ids": ["R-DME-69273", "R-DME-209155", "R-RNO-2995383", "R-DME-432553", "R-CEL-975957", "R-DME-2995383", "R-DDI-69273", "R-DME-69231", "R-HSA-69273", "R-SPO-975957", "R-HSA-69231", "R-DME-9860927", "R-RNO-9860927", "R-DME-209214", "R-SCE-975957", "R-DME-209396", "R-SPO-69273", "R-CEL-69231", "R-MMU-2995383", "R-DME-209413", "R-SCE-69273", "R-CEL-69273", "R-RNO-975957", "R-DME-209190", "R-DME-209360", "R-CEL-9860927", "R-DDI-69231", "R-DME-209461", "R-MMU-975957", "R-CEL-2995383", "R-HSA-2995383", "R-RNO-69273", "R-RNO-69231", "R-DME-432620", "R-HSA-975957", "R-HSA-2465910", "R-DME-209440", "R-HSA-9860927", "R-MMU-69273", "R-DME-975957", "R-MMU-9860927", "R-MMU-69231"], "pathways": ["R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-209214:r:Phosphorylation of SMO", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-209396:r:Phosphorylation of ARM", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-69231:r:Cyclin D associated events in G1", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-209190:r:Phosphorylation of CI", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DDI-69231:r:Cyclin D associated events in G1", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69231:r:Cyclin D associated events in G1", "R-DME-432620:r:Dephosphorylation of PER", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Family"}, "IPR000010": {"description": "Cystatin domain", "go_ids": ["GO:0004869"], "go_terms": ["GO:0004869:cysteine-type endopeptidase inhibitor activity:F"], "name": "Cystatin_dom", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-SSC-6798695", "R-HSA-6809371", "R-HSA-375276", "R-CEL-6798695", "R-HSA-140837", "R-HSA-977225", "R-MMU-75205", "R-BTA-6798695", "R-HSA-416476", "R-MMU-8957275", "R-RNO-114608", "R-RNO-418594", "R-RNO-140837", "R-BTA-8957275", "R-RNO-381426", "R-HSA-114608", "R-BTA-114608", "R-HSA-418594", "R-MMU-6809371", "R-RNO-8957275", "R-RNO-375276", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-BTA-381426", "R-SSC-6809371", "R-MMU-6798695", "R-HSA-8957275", "R-RNO-75205", "R-RNO-416476", "R-HSA-75205", "R-HSA-381426", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-6809371:r:Formation of the cornified envelope", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-6809371:r:Formation of the cornified envelope", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR000012": {"description": "Retroviral VpR/VpX protein", "go_ids": ["GO:0042025", "GO:0019058"], "go_terms": ["GO:0042025:host cell nucleus:C", "GO:0019058:viral life cycle:P"], "name": "RetroV_VpR/X", "pathway_ids": ["R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-164525", "R-HSA-162585", "R-HSA-180897", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-173107", "R-HSA-162594"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-180897:r:Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Family"}, "IPR000013": {"description": "Peptidase M7, snapalysin", "go_ids": ["GO:0004222", "GO:0005576", "GO:0006508", "GO:0008270"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0005576:extracellular region:C", "GO:0006508:proteolysis:P", "GO:0008270:zinc ion binding:F"], "name": "Peptidase_M7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000014": {"description": "PAS domain", "go_ids": [], "go_terms": [], "name": "PAS", "pathway_ids": ["R-RNO-193807", "R-DME-1296072", "R-DRE-211976", "R-DRE-192105", "R-CEL-211945", "R-HSA-8951664", "R-HSA-5689880", "R-DRE-400206", "R-MMU-5689880", "R-CEL-1234176", "R-HSA-9844594", "R-HSA-9931530", "R-DDI-5673000", "R-RNO-8857538", "R-HSA-9701898", "R-HSA-2122947", "R-HSA-1234176", "R-DME-432524", "R-DME-538898", "R-MMU-9932298", "R-HSA-418555", "R-HSA-9931521", "R-HSA-192105", "R-HSA-452723", "R-MMU-1234176", "R-RNO-5689880", "R-RNO-211945", "R-DME-432620", "R-DDI-5674135", "R-DME-432408", "R-MMU-211976", "R-RNO-8951664", "R-SPO-2465910", "R-DME-211945", "R-DME-1234176", "R-RNO-9841922", "R-HSA-9931529", "R-DRE-9707564", "R-MMU-5687128", "R-HSA-9768919", "R-HSA-9664873", "R-MMU-193807", "R-HSA-8857538", "R-HSA-5576890", "R-MMU-5576890", "R-RNO-1234176", "R-DRE-9768919", "R-RNO-9932298", "R-DME-432553", "R-DME-418555", "R-HSA-211945", "R-HSA-1234174", "R-DRE-193368", "R-HSA-193368", "R-MMU-8937144", "R-DME-1234158", "R-HSA-5625886", "R-DME-432490", "R-DME-9768919", "R-DME-8937144", "R-MMU-9029569", "R-MMU-3214847", "R-DRE-8937144", "R-RNO-400206", "R-MMU-193368", "R-MMU-3899300", "R-HSA-381340", "R-HSA-9707616", "R-DME-432626", "R-DDI-5675221", "R-CEL-5689880", "R-HSA-9909649", "R-RNO-3214847", "R-DME-9932298", "R-HSA-1296072", "R-DRE-211945", "R-HSA-3214847", "R-HSA-159418", "R-HSA-2426168", "R-MMU-418555", "R-MMU-9707564", "R-CEL-8951664", "R-SSC-5576890", "R-HSA-1989781", "R-HSA-211981", "R-MMU-1234174", "R-DRE-193807", "R-HSA-2151201", "R-CFA-5576890", "R-HSA-1234158", "R-DME-8951664", "R-HSA-9932298", "R-RNO-211981", "R-HSA-1368108", "R-HSA-9841922", "R-SSC-1296072", "R-MMU-8951664", "R-MMU-1234158", "R-HSA-9933387", "R-HSA-9707564", "R-DRE-3214847", "R-HSA-9018519", "R-DRE-211981", "R-RNO-8937144", "R-DRE-5625886", "R-MMU-192105", "R-RNO-1234174", "R-HSA-6785807", "R-HSA-193807", "R-MMU-9018519", "R-DRE-159418", "R-HSA-9768778", "R-MMU-9768919", "R-RNO-211976", "R-RNO-193368", "R-HSA-400206", "R-CEL-8937144", "R-HSA-211976", "R-MMU-400206", "R-HSA-9623433", "R-MMU-211945", "R-HSA-5617472", "R-RNO-5576890", "R-BTA-1296072", "R-RNO-192105", "R-DME-432560", "R-MMU-211981", "R-MMU-8857538", "R-RNO-159418", "R-RNO-5625886", "R-HSA-8849473", "R-MMU-5625886", "R-HSA-9029569", "R-HSA-9931509", "R-HSA-8937144", "R-MMU-1296072", "R-CEL-1234158", "R-RNO-9768919", "R-MMU-9623433", "R-CFA-1296072", "R-RNO-9707564", "R-RNO-1296072", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-5687128", "R-DME-432395", "R-RNO-1234158", "R-HSA-3899300", "R-CEL-9768919", "R-MMU-159418", "R-DME-432501"], "pathways": ["R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DME-1296072:r:Voltage gated Potassium channels", "R-DRE-211976:r:Endogenous sterols", "R-DRE-192105:r:Synthesis of bile acids and bile salts", "R-CEL-211945:r:Phase I - Functionalization of compounds", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-DDI-5673000:r:RAF activation", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-432524:r:Degradation of PER", "R-DME-538898:r:Dephosphorylation of TIM", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-DME-432620:r:Dephosphorylation of PER", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-DME-432408:r:Transcription regulation of cwo gene", "R-MMU-211976:r:Endogenous sterols", "R-RNO-8951664:r:Neddylation", "R-SPO-2465910:r:MASTL Facilitates Mitotic Progression", "R-DME-211945:r:Phase I - Functionalization of compounds", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9931529:r:Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9664873:r:Pexophagy", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-9768919:r:NPAS4 regulates expression of target genes", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-418555:r:G alpha (s) signalling events", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-HSA-1234174:r:Cellular response to hypoxia", "R-DRE-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-8937144:r:Aryl hydrocarbon receptor signalling", "R-DME-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DME-432490:r:Nuclear import of PER and TIM", "R-DME-9768919:r:NPAS4 regulates expression of target genes", "R-DME-8937144:r:Aryl hydrocarbon receptor signalling", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-3214847:r:HATs acetylate histones", "R-DRE-8937144:r:Aryl hydrocarbon receptor signalling", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-DME-432626:r:Circadian Clock pathway", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-3214847:r:HATs acetylate histones", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-DRE-211945:r:Phase I - Functionalization of compounds", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-418555:r:G alpha (s) signalling events", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-8951664:r:Neddylation", "R-SSC-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-211981:r:Xenobiotics", "R-MMU-1234174:r:Cellular response to hypoxia", "R-DRE-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-CFA-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-DME-8951664:r:Neddylation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-RNO-211981:r:Xenobiotics", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SSC-1296072:r:Voltage gated Potassium channels", "R-MMU-8951664:r:Neddylation", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-DRE-3214847:r:HATs acetylate histones", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DRE-211981:r:Xenobiotics", "R-RNO-8937144:r:Aryl hydrocarbon receptor signalling", "R-DRE-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-RNO-1234174:r:Cellular response to hypoxia", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DRE-159418:r:Recycling of bile acids and salts", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-MMU-9768919:r:NPAS4 regulates expression of target genes", "R-RNO-211976:r:Endogenous sterols", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-CEL-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-211976:r:Endogenous sterols", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-5576890:r:Phase 3 - rapid repolarisation", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-DME-432560:r:Transcription activation by CLK:CYC and repression by VRI", "R-MMU-211981:r:Xenobiotics", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-8849473:r:PTK6 Expression", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling", "R-MMU-1296072:r:Voltage gated Potassium channels", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-9768919:r:NPAS4 regulates expression of target genes", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-CFA-1296072:r:Voltage gated Potassium channels", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-432395:r:Degradation of TIM", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9768919:r:NPAS4 regulates expression of target genes", "R-MMU-159418:r:Recycling of bile acids and salts", "R-DME-432501:r:Transcription repression by PER and activation by PDP1"], "type": "Domain"}, "IPR000015": {"description": "Outer membrane usher protein", "go_ids": ["GO:0016020", "GO:0009297", "GO:0015473"], "go_terms": ["GO:0016020:membrane:C", "GO:0009297:pilus assembly:P", "GO:0015473:fimbrial usher porin activity:F"], "name": "Fimb_usher", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000020": {"description": "Anaphylatoxin/fibulin", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Anaphylatoxin/fibulin", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-MMU-166663", "R-BTA-6798695", "R-CEL-1566948", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-977606", "R-RNO-418594", "R-BTA-8957275", "R-CEL-1474228", "R-BTA-418594", "R-CEL-2129379", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-MMU-174577", "R-HSA-174577", "R-BTA-381426", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-CEL-216083", "R-MMU-977606", "R-HSA-2129379", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-BTA-375276", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-CEL-2173789", "R-RNO-6798695", "R-MMU-2129379"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-1566948:r:Elastic fibre formation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-418594:r:G alpha (i) signalling events", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-BTA-418594:r:G alpha (i) signalling events", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-HSA-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-CEL-216083:r:Integrin cell surface interactions", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR000021": {"description": "Hok/gef cell toxic protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Hok/gef_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000023": {"description": "Phosphofructokinase domain", "go_ids": ["GO:0003872", "GO:0006096"], "go_terms": ["GO:0003872:6-phosphofructokinase activity:F", "GO:0006096:glycolytic process:P"], "name": "Phosphofructokinase_dom", "pathway_ids": ["PWY-5484", "PWY-1861", "PWY-1042", "PWY-7385", "R-RNO-6798695", "R-HSA-6798695", "R-SPO-6798695", "R-MMU-70171", "R-SCE-70171", "R-DME-6798695", "R-BTA-70171", "R-CEL-6798695", "R-SCE-6798695", "R-DME-70171", "R-BTA-6798695", "R-CEL-70171", "R-RNO-70171", "R-MMU-6798695", "R-HSA-70171", "R-SPO-70171"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1042:t:glycolysis IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-70171:r:Glycolysis", "R-SCE-70171:r:Glycolysis", "R-DME-6798695:r:Neutrophil degranulation", "R-BTA-70171:r:Glycolysis", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-70171:r:Glycolysis", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-70171:r:Glycolysis", "R-RNO-70171:r:Glycolysis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis"], "type": "Domain"}, "IPR000026": {"description": "Guanine-specific ribonuclease N1-like", "go_ids": ["GO:0003723", "GO:0004521"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0004521:RNA endonuclease activity:F"], "name": "N1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000028": {"description": "Chloroperoxidase", "go_ids": ["GO:0004601"], "go_terms": ["GO:0004601:peroxidase activity:F"], "name": "Chloroperoxidase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000030": {"description": "PPE domain", "go_ids": [], "go_terms": [], "name": "PPE_dom", "pathway_ids": ["R-HSA-9636249"], "pathways": ["R-HSA-9636249:r:Inhibition of nitric oxide production"], "type": "Domain"}, "IPR000031": {"description": "PurE domain", "go_ids": ["GO:0006189"], "go_terms": ["GO:0006189:'de novo' IMP biosynthetic process:P"], "name": "PurE_dom", "pathway_ids": ["R-RNO-73817", "R-MMU-73817", "R-CEL-73817", "R-HSA-73817", "R-DME-73817", "R-GGA-419140"], "pathways": ["R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Domain"}, "IPR000032": {"description": "Phosphocarrier protein HPr-like", "go_ids": [], "go_terms": [], "name": "HPr-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000033": {"description": "LDLR class B repeat", "go_ids": [], "go_terms": [], "name": "LDLR_classB_rpt", "pathway_ids": ["R-MMU-8856828", "R-MMU-182971", "R-MMU-6785631", "R-MMU-180336", "R-BTA-8964026", "R-MMU-4641263", "R-HSA-180292", "R-MMU-8964046", "R-MMU-6811558", "R-HSA-3000178", "R-HSA-8856828", "R-RNO-8866376", "R-HSA-2168880", "R-HSA-432142", "R-RNO-9009391", "R-RNO-3000157", "R-MMU-9009391", "R-RNO-8964026", "R-HSA-9927418", "R-GGA-8866376", "R-RNO-8964038", "R-RNO-8863795", "R-MMU-432142", "R-MMU-975634", "R-RNO-9758890", "R-HSA-8863795", "R-HSA-9818030", "R-RNO-6811558", "R-RNO-8847993", "R-RNO-1963642", "R-HSA-177929", "R-MMU-1236394", "R-HSA-9013507", "R-HSA-9664565", "R-RNO-5673001", "R-MMU-5673001", "R-RNO-8964046", "R-RNO-8866427", "R-MMU-2168880", "R-HSA-212718", "R-MMU-1474228", "R-RNO-212718", "R-HSA-1474228", "R-RNO-179812", "R-DME-1227986", "R-HSA-182971", "R-HSA-9665686", "R-MMU-180292", "R-DME-1236394", "R-HSA-8847993", "R-RNO-2168880", "R-DME-6785631", "R-DME-114608", "R-RNO-9013507", "R-DME-212718", "R-HSA-2219530", "R-HSA-5637810", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-196791", "R-MMU-8866427", "R-MMU-9758890", "R-MMU-179812", "R-MMU-4641262", "R-MMU-1963642", "R-DME-1250196", "R-DME-1257604", "R-MMU-1250196", "R-DME-182971", "R-HSA-1257604", "R-HSA-179812", "R-DME-1963642", "R-MMU-114608", "R-MMU-8863795", "R-HSA-201681", "R-HSA-5638303", "R-DME-180336", "R-MMU-3772470", "R-RNO-6785631", "R-HSA-9725554", "R-DME-5673001", "R-MMU-8856825", "R-HSA-3000157", "R-HSA-977225", "R-RNO-1257604", "R-HSA-9665348", "R-HSA-1251932", "R-HSA-8964046", "R-RNO-114608", "R-DME-6811558", "R-HSA-114608", "R-BTA-114608", "R-HSA-196791", "R-MMU-8847993", "R-MMU-9013507", "R-HSA-1236382", "R-MMU-8964038", "R-HSA-4641262", "R-HSA-1963642", "R-DME-8856828", "R-HSA-5340588", "R-HSA-1250196", "R-RNO-975634", "R-RNO-8856828", "R-RNO-177929", "R-DME-8863795", "R-BTA-8856828", "R-HSA-3772470", "R-HSA-1963640", "R-DME-180292", "R-DME-8856825", "R-MMU-3000157", "R-RNO-8856825", "R-HSA-5339717", "R-HSA-4641263", "R-HSA-8964026", "R-MMU-1227986", "R-RNO-1227986", "R-HSA-6785631", "R-HSA-9927432", "R-HSA-1227986", "R-HSA-9937080", "R-MMU-1257604", "R-MMU-8964026", "R-RNO-180292", "R-HSA-9758890", "R-HSA-9634638", "R-DME-177929", "R-HSA-180336", "R-HSA-1236394", "R-DME-1474228", "R-BTA-8856825", "R-HSA-9009391", "R-MMU-212718", "R-HSA-8866427", "R-GGA-8866427", "R-BTA-8964038", "R-HSA-8856825", "R-MMU-8866376", "R-RNO-180336", "R-RNO-1236394", "R-RNO-1250196", "R-RNO-182971", "R-HSA-8866376", "R-DME-179812", "R-HSA-8964038", "R-HSA-975634", "R-MMU-177929"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-182971:r:EGFR downregulation", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-BTA-8964026:r:Chylomicron clearance", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-8964046:r:VLDL clearance", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8866376:r:Reelin signalling pathway", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-432142:r:Platelet sensitization by LDL", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-3000157:r:Laminin interactions", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-8964026:r:Chylomicron clearance", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-GGA-8866376:r:Reelin signalling pathway", "R-RNO-8964038:r:LDL clearance", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-432142:r:Platelet sensitization by LDL", "R-MMU-975634:r:Retinoid metabolism and transport", "R-RNO-9758890:r:Transport of RCbl within the body", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-1236394:r:Signaling by ERBB4", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-8964046:r:VLDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-182971:r:EGFR downregulation", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-180292:r:GAB1 signalosome", "R-DME-1236394:r:Signaling by ERBB4", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-DME-114608:r:Platelet degranulation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-9758890:r:Transport of RCbl within the body", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-182971:r:EGFR downregulation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-114608:r:Platelet degranulation", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000157:r:Laminin interactions", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-8964046:r:VLDL clearance", "R-RNO-114608:r:Platelet degranulation", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-8964038:r:LDL clearance", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-177929:r:Signaling by EGFR", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-180292:r:GAB1 signalosome", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-3000157:r:Laminin interactions", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-1227986:r:Signaling by ERBB2", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-8964026:r:Chylomicron clearance", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-9758890:r:Transport of RCbl within the body", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DME-177929:r:Signaling by EGFR", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-HSA-1236394:r:Signaling by ERBB4", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8866376:r:Reelin signalling pathway", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-RNO-1236394:r:Signaling by ERBB4", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-182971:r:EGFR downregulation", "R-HSA-8866376:r:Reelin signalling pathway", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-HSA-8964038:r:LDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport", "R-MMU-177929:r:Signaling by EGFR"], "type": "Repeat"}, "IPR000034": {"description": "Laminin IV", "go_ids": [], "go_terms": [], "name": "Laminin_IV", "pathway_ids": ["R-HSA-8874081", "R-HSA-3000157", "R-HSA-3000178", "R-HSA-3560783", "R-HSA-977225", "R-HSA-9918485", "R-HSA-9619665", "R-HSA-9856532", "R-HSA-3656237", "R-HSA-373760", "R-HSA-9638630", "R-HSA-3656253", "R-HSA-2024096", "R-HSA-2022928", "R-HSA-9833110", "R-HSA-446107", "R-HSA-9918481", "R-HSA-381426", "R-HSA-1474228", "R-HSA-9925563", "R-HSA-2214320", "R-HSA-216083", "R-HSA-9913351", "R-HSA-3000171", "R-HSA-1971475", "R-HSA-9694614", "R-HSA-6785807", "R-HSA-3560801", "R-HSA-9820960", "R-HSA-2022090", "R-HSA-4420332", "R-HSA-8957275", "R-HSA-975634"], "pathways": ["R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-3000157:r:Laminin interactions", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-HSA-2024096:r:HS-GAG degradation", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Domain"}, "IPR000036": {"description": "Peptidase A26, omptin", "go_ids": ["GO:0004175", "GO:0006508", "GO:0009279"], "go_terms": ["GO:0004175:endopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0009279:cell outer membrane:C"], "name": "Peptidase_A26_omptin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000037": {"description": "SsrA-binding protein", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "SsrA-bd_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000039": {"description": "Large ribosomal subunit protein eL18", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL18", "pathway_ids": ["R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DME-1799339", "R-DDI-9954709", "R-HSA-9918481", "R-CFA-72689", "R-SCE-72689", "R-MMU-975956", "R-CFA-9954716", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-CFA-975956", "R-BTA-975956", "R-BTA-9954709", "R-SSC-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012", "R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-CFA-1799339", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-CFA-72706", "R-DDI-9954714", "R-CEL-72706", "R-CFA-9954709", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-SPO-975956", "R-SPO-9954709", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-SSC-9954714", "R-HSA-72706", "R-CFA-6791226", "R-CEL-156827", "R-CFA-156827", "R-RNO-6791226", "R-SSC-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SSC-72689", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-MMU-1799339", "R-CFA-9954714", "R-DDI-72689", "R-DDI-975956", "R-HSA-9954716", "R-CFA-975957", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SSC-9954716"], "pathways": ["R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CFA-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", 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"R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-5578775:r:Ion homeostasis", "R-DME-425381:r:Bicarbonate transporters", "R-DDI-156581:r:Methylation", "R-BTA-425381:r:Bicarbonate transporters", "R-HSA-425381:r:Bicarbonate transporters", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-156581:r:Methylation", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-BTA-156581:r:Methylation", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-DME-1614635:r:Sulfur amino acid metabolism", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Family"}, "IPR000045": {"description": "Prepilin type IV endopeptidase, peptidase domain", "go_ids": ["GO:0004190", "GO:0016020"], "go_terms": ["GO:0004190:aspartic-type endopeptidase activity:F", "GO:0016020:membrane:C"], "name": "Prepilin_IV_endopep_pep", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR000048": {"description": "IQ motif, EF-hand binding site", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "IQ_motif_EF-hand-BS", "pathway_ids": ["R-RNO-9013026", "R-HSA-6798695", "R-HSA-9013409", "R-HSA-5674135", "R-HSA-6802952", "R-MMU-9013106", "R-HSA-264876", "R-MMU-9013408", "R-CEL-2453902", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-DME-445355", "R-SPO-9013106", "R-MMU-9013420", "R-HSA-432040", "R-HSA-9662360", "R-HSA-9649948", "R-SCE-8980692", "R-DME-2453902", "R-RNO-9013424", "R-SCE-9013425", "R-SCE-9013420", "R-HSA-9013408", "R-BTA-5250924", "R-MMU-5620912", "R-HSA-5655302", "R-HSA-6802955", "R-HSA-5635838", "R-SPO-5626467", "R-HSA-373753", "R-MMU-9013419", "R-MMU-9035034", "R-MMU-5250924", "R-HSA-6802948", "R-HSA-2514859", "R-RNO-9824585", "R-MMU-390522", "R-MMU-2453902", "R-HSA-416482", "R-HSA-2029482", "R-RNO-9013148", "R-HSA-373752", "R-GGA-9824585", "R-MMU-432040", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-373753", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-9620244", "R-HSA-381676", "R-MMU-9013406", "R-SPO-190873", "R-HSA-1445148", "R-SPO-9013424", "R-MMU-193648", "R-MMU-9013149", "R-HSA-9013026", "R-DRE-9013026", "R-DRE-8980692", "R-MMU-6798695", "R-MMU-5627123", "R-DDI-9013418", "R-HSA-9656223", "R-HSA-1839117", "R-SPO-6798695", "R-HSA-416572", "R-HSA-5625900", "R-MMU-5674135", "R-HSA-5626467", "R-HSA-9662834", "R-HSA-445095", "R-MMU-8980692", "R-RNO-9035034", "R-RNO-8980692", "R-SCE-6798695", "R-RNO-373760", "R-HSA-5625740", "R-HSA-9013106", "R-MMU-9013148", "R-HSA-373760", "R-DDI-9013422", "R-RNO-2029482", "R-HSA-5576892", "R-BTA-5627123", "R-SPO-9013406", "R-SCE-5626467", "R-SCE-9013406", "R-HSA-6802946", "R-HSA-9035034", "R-MMU-9824585", "R-MMU-2514859", "R-HSA-9013148", "R-BTA-373760", "R-MMU-9013425", "R-SPO-9013420", "R-RNO-8985586", "R-RNO-9013106", "R-SCE-190873", "R-SCE-9013424", "R-HSA-5620912", "R-HSA-193648", "R-HSA-9013420", "R-RNO-390522", "R-HSA-445355", "R-MMU-5626467", "R-SPO-9013419", "R-DRE-9013424", "R-SPO-9013425", "R-HSA-9662361", "R-HSA-9927432", "R-MMU-9013424", "R-RNO-5250924", "R-DME-350480", "R-HSA-983168", "R-MMU-8985586", "R-MMU-2029482", "R-SCE-9013106", "R-HSA-9824585", "R-HSA-9703465", "R-HSA-8985586", "R-HSA-9717207", "R-HSA-3928663", "R-HSA-5627123", "R-XTR-983168", "R-MMU-9013026", "R-MMU-416482", "R-SCE-9013419", "R-HSA-5250924", "R-MMU-983168", "R-HSA-9013406", "R-RNO-432040", "R-HSA-9664422", "R-HSA-9725370", "R-MMU-373760", "R-HSA-5627117", "R-HSA-2453902"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-264876:r:Insulin processing", "R-MMU-9013408:r:RHOG GTPase cycle", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DME-445355:r:Smooth Muscle Contraction", "R-SPO-9013106:r:RHOC GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-SCE-8980692:r:RHOA GTPase cycle", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013424:r:RHOV GTPase cycle", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013420:r:RHOU GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-5635838:r:Activation of SMO", "R-SPO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-373753:r:Nephrin family interactions", "R-MMU-9013419:r:RHOT2 GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-390522:r:Striated Muscle Contraction", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-GGA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-373753:r:Nephrin family interactions", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9620244:r:Long-term potentiation", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-190873:r:Gap junction degradation", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-SPO-9013424:r:RHOV GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-9013026:r:RHOB GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-373760:r:L1CAM interactions", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-373760:r:L1CAM interactions", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-SCE-5626467:r:RHO GTPases activate IQGAPs", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-373760:r:L1CAM interactions", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-RNO-9013106:r:RHOC GTPase cycle", "R-SCE-190873:r:Gap junction degradation", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-DRE-9013424:r:RHOV GTPase cycle", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-9013106:r:RHOC GTPase cycle", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-373760:r:L1CAM interactions", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Binding_site"}, "IPR000052": {"description": "Potex/carlavirus coat protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Pltvir_coat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000053": {"description": "Thymidine/pyrimidine-nucleoside phosphorylase", "go_ids": ["GO:0006206", "GO:0004645"], "go_terms": ["GO:0006206:pyrimidine nucleobase metabolic process:P", "GO:0004645:1,4-alpha-oligoglucan phosphorylase activity:F"], "name": "Thymidine/pyrmidine_PPase", "pathway_ids": ["PWY-7181", "R-RNO-73621", "R-MMU-73614", "R-HSA-73621", "R-HSA-73614", "R-MMU-73621", "R-RNO-73614"], "pathways": ["PWY-7181:t:pyrimidine deoxyribonucleosides degradation", "R-RNO-73621:r:Pyrimidine catabolism", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-73614:r:Pyrimidine salvage"], "type": "Family"}, "IPR000054": {"description": "Large ribosomal subunit protein eL31", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL31", "pathway_ids": ["R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954716", "R-CEL-9954714", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-SPO-9954709", "R-SPO-975956", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-SCE-975956", "R-SSC-9954714", "R-CEL-1799339", "R-HSA-72706", "R-SSC-1799339", "R-RNO-6791226", "R-CEL-156827", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-SSC-72689", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-CEL-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-RNO-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SSC-9954716", "R-SSC-156827", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-HSA-975957", "R-DME-9954714", "R-SSC-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-DDI-9954716", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000055": {"description": "Type I restriction modification DNA specificity domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Restrct_endonuc_typeI_TRD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000056": {"description": "Ribulose-phosphate 3-epimerase-like", "go_ids": ["GO:0005975", "GO:0016857"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016857:racemase and epimerase activity, acting on carbohydrates and derivatives:F"], "name": "Ribul_P_3_epim-like", "pathway_ids": ["PWY-1861", "PWY-8178", "PWY-5723", "R-MMU-71336", "R-HSA-71336", "R-SPO-71336", "R-SCE-71336"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-5723:t:Rubisco shunt", "R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-SCE-71336:r:Pentose phosphate pathway"], "type": "Family"}, "IPR000058": {"description": "Zinc finger, AN1-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_AN1", "pathway_ids": ["R-BTA-9033241", "R-RNO-9033241", "R-HSA-9033241", "R-MMU-9033241"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR000060": {"description": "BCCT transporter family", "go_ids": ["GO:0016020", "GO:0071705", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0071705:nitrogen compound transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "BCCT_transptr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000061": {"description": "SWAP/Surp", "go_ids": ["GO:0003723", "GO:0006396"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006396:RNA processing:P"], "name": "Surp", "pathway_ids": ["R-SPO-9770562", "R-HSA-72163", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-RNO-9770562", "R-BTA-9770562", "R-DDI-9770562", "R-HSA-9918481", "R-BTA-72163"], "pathways": ["R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR000064": {"description": "Endopeptidase, NLPC/P60 domain", "go_ids": [], "go_terms": [], "name": "NLP_P60_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000065": {"description": "Leptin", "go_ids": ["GO:0005179", "GO:0005576", "GO:0007165"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C", "GO:0007165:signal transduction:P"], "name": "Leptin", "pathway_ids": ["R-MMU-422085", "R-RNO-381771", "R-MMU-381771", "R-HSA-381340", "R-RNO-422085", "R-HSA-381771", "R-HSA-2586552", "R-HSA-422085"], "pathways": ["R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin"], "type": "Family"}, "IPR000066": {"description": "Antenna complex, alpha/beta subunit", "go_ids": ["GO:0019684", "GO:0030077", "GO:0016020"], "go_terms": ["GO:0019684:photosynthesis, light reaction:P", "GO:0030077:plasma membrane light-harvesting complex:C", "GO:0016020:membrane:C"], "name": "Antenna_a/b", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000067": {"description": "Flagellar M-ring protein FliF", "go_ids": ["GO:0003774", "GO:0009431", "GO:0071973"], "go_terms": ["GO:0003774:cytoskeletal motor activity:F", "GO:0009431:bacterial-type flagellum basal body, MS ring:C", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "FlgMring_FliF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000068": {"description": "GPCR, family 3, extracellular calcium-sensing receptor-related", "go_ids": ["GO:0004930", "GO:0007186", "GO:0016020"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F", "GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "GPCR_3_Ca_sens_rcpt-rel", "pathway_ids": ["R-DRE-420499", "R-MMU-416476", "R-BTA-420499", "R-RNO-9717207", "R-MMU-420499", "R-HSA-420499", "R-SSC-420499", "R-RNO-420499", "R-HSA-416476", "R-SSC-416476", "R-MMU-418594", "R-RNO-418594", "R-BTA-416476", "R-BTA-418594", "R-HSA-418594", "R-HSA-9717207", "R-MMU-9717207", "R-SSC-418594", "R-DRE-416476", "R-RNO-416476"], "pathways": ["R-DRE-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-416476:r:G alpha (q) signalling events", "R-BTA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-SSC-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-416476:r:G alpha (q) signalling events", "R-SSC-416476:r:G alpha (q) signalling events", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-BTA-416476:r:G alpha (q) signalling events", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami 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deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR000070": {"description": "Pectinesterase, catalytic", "go_ids": ["GO:0030599", "GO:0042545"], "go_terms": ["GO:0030599:pectinesterase activity:F", "GO:0042545:cell wall modification:P"], "name": "Pectinesterase_cat", "pathway_ids": ["PWY-7246", "PWY-7248"], "pathways": ["PWY-7246:t:pectin degradation I", "PWY-7248:t:pectin degradation II"], "type": "Domain"}, "IPR000071": {"description": "Immunodeficiency lentiviral matrix, N-terminal", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Lentvrl_matrix_N", "pathway_ids": ["R-HSA-180910", "R-HSA-164516", "R-HSA-162585", "R-HSA-1169408", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-164525", "R-HSA-162594", "R-HSA-162592", "R-HSA-177539", "R-HSA-174490", "R-HSA-175567", "R-HSA-175474", "R-HSA-174495", "R-HSA-173107"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-174495:r:Synthesis And Processing Of GAG, GAGPOL Polyproteins", "R-HSA-173107:r:Binding and entry of HIV virion"], "type": "Domain"}, "IPR000072": {"description": "PDGF/VEGF domain", "go_ids": ["GO:0008083", "GO:0016020"], "go_terms": ["GO:0008083:growth factor activity:F", "GO:0016020:membrane:C"], "name": "PDGF/VEGF_dom", "pathway_ids": ["R-HSA-186797", "R-DRE-114608", "R-MMU-6811558", "R-HSA-1234158", "R-BTA-5673001", "R-RNO-1257604", "R-DRE-5218921", "R-MMU-4420097", "R-RNO-114608", "R-HSA-194313", "R-HSA-4420097", "R-BTA-186763", "R-HSA-114608", "R-BTA-114608", "R-GGA-186797", "R-BTA-4420097", "R-HSA-9818030", "R-RNO-6811558", "R-BTA-6811558", "R-HSA-8866910", "R-BTA-186797", "R-BTA-195399", "R-HSA-195399", "R-RNO-5673001", "R-MMU-5673001", "R-MMU-186763", "R-DRE-195399", "R-MMU-194313", "R-BTA-194313", "R-MMU-5218921", "R-DRE-194313", "R-HSA-3000171", 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"R-DRE-3000480:r:Scavenging by Class A Receptors", "R-HSA-9918432:r:Maturation of DENV proteins", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-BTA-8963901:r:Chylomicron remodeling", "R-DRE-8964011:r:HDL clearance", "R-BTA-9707616:r:Heme signaling", "R-BTA-975634:r:Retinoid metabolism and transport", "R-RNO-8964011:r:HDL clearance", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8964058:r:HDL remodeling", "R-RNO-8963896:r:HDL assembly", "R-GGA-8963896:r:HDL assembly", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-3000471:r:Scavenging by Class B Receptors", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-GGA-8963888:r:Chylomicron assembly", "R-MMU-114608:r:Platelet degranulation", "R-HSA-8964011:r:HDL clearance", "R-DRE-114608:r:Platelet degranulation", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8964058:r:HDL remodeling", "R-GGA-9707616:r:Heme signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-BTA-8964058:r:HDL remodeling", "R-BTA-3000471:r:Scavenging by Class B Receptors", "R-GGA-8964058:r:HDL remodeling", "R-GGA-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-8963896:r:HDL assembly", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964058:r:HDL remodeling", "R-HSA-8964026:r:Chylomicron clearance", "R-GGA-2168880:r:Scavenging of heme from plasma", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-GGA-114608:r:Platelet degranulation", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-5682113:r:Defective ABCA1 causes TGD", "R-MMU-8963896:r:HDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-BTA-8964011:r:HDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Family"}, "IPR000077": {"description": "Large ribosomal subunit protein eL39", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL39", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-CEL-72706", "R-GGA-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-GGA-9954716", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-CEL-72689", "R-MMU-1799339", "R-GGA-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-GGA-9954714", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-GGA-9954709", "R-BTA-9954714", "R-GGA-975957", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-GGA-1799339", "R-DME-975957", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000079": {"description": "High mobility group protein HMGN", "go_ids": ["GO:0000785", "GO:0005634", "GO:0031492"], "go_terms": ["GO:0000785:chromatin:C", "GO:0005634:nucleus:C", "GO:0031492:nucleosomal DNA binding:F"], "name": "HMGN_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000081": {"description": "Peptidase C3, picornavirus core protein 2A", "go_ids": ["GO:0006508", "GO:0008233", "GO:0016032"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008233:peptidase activity:F", "GO:0016032:viral process:P"], "name": "Peptidase_C3", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR000082": {"description": "SEA domain", "go_ids": [], "go_terms": [], "name": "SEA_dom", "pathway_ids": ["R-HSA-5083632", "R-MMU-2024096", "R-HSA-3560783", "R-HSA-3000178", "R-HSA-9918485", "R-CEL-1566948", "R-HSA-3656237", "R-HSA-9856532", "R-HSA-9927418", "R-RNO-2024096", "R-MMU-975634", "R-CEL-2129379", "R-MMU-3000178", "R-HSA-5083625", "R-CEL-381426", "R-CEL-8957275", "R-HSA-9696273", "R-HSA-5621480", "R-RNO-913709", "R-RNO-3000178", "R-MMU-1474228", "R-HSA-1474228", "R-CEL-216083", "R-HSA-3000171", "R-HSA-1971475", "R-HSA-9694614", "R-RNO-9696273", "R-HSA-6785807", "R-HSA-419037", "R-HSA-9696264", "R-HSA-3560801", "R-HSA-9820960", "R-MMU-9913351", "R-HSA-5683826", "R-HSA-4420332", "R-RNO-9696264", "R-MMU-9696264", "R-CEL-2173789", "R-HSA-6809371", "R-HSA-977068", "R-RNO-9696270", "R-MMU-913709", "R-HSA-3000157", "R-HSA-977225", "R-CEL-1474228", "R-HSA-3656253", "R-RNO-977068", "R-HSA-913709", "R-HSA-2024096", "R-MMU-2022928", "R-MMU-977068", "R-HSA-9833110", "R-HSA-2022928", "R-RNO-975634", "R-HSA-9918481", "R-MMU-5683826", "R-HSA-1442490", "R-HSA-5083636", "R-HSA-216083", "R-HSA-9696270", "R-HSA-9913351", "R-RNO-5683826", "R-RNO-9913351", "R-RNO-1971475", "R-RNO-2022928", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-1971475", "R-MMU-1442490", "R-HSA-975634", "R-HSA-9927426"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-CEL-1566948:r:Elastic fibre formation", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-RNO-2024096:r:HS-GAG degradation", "R-MMU-975634:r:Retinoid metabolism and transport", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-5621480:r:Dectin-2 family", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9694614:r:Attachment and Entry", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-3000157:r:Laminin interactions", "R-HSA-977225:r:Amyloid fiber formation", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-RNO-977068:r:Termination of O-glycan biosynthesis", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-2024096:r:HS-GAG degradation", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-1442490:r:Collagen degradation", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-5683826:r:Surfactant metabolism", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-1442490:r:Collagen degradation", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Domain"}, "IPR000083": {"description": "Fibronectin, type I", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Fibronectin_type1", "pathway_ids": ["R-HSA-186797", "R-HSA-8874081", "R-HSA-5674135", "R-HSA-9700645", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-RNO-1474228", "R-HSA-140837", "R-GGA-354194", "R-GGA-354192", "R-MMU-8957275", "R-MMU-3000170", "R-HSA-6806942", "R-RNO-140837", "R-RNO-9634597", "R-MMU-3000178", "R-HSA-9649948", "R-RNO-202733", "R-MMU-202733", "R-MMU-381426", "R-GGA-8957275", "R-RNO-3000178", "R-HSA-6802955", "R-HSA-75205", "R-GGA-3000170", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-6802948", "R-RNO-1566977", "R-GGA-216083", "R-GGA-2129379", "R-MMU-9634597", "R-HSA-3000171", "R-MMU-140837", "R-GGA-202733", "R-HSA-6785807", "R-GGA-5674135", "R-RNO-381426", "R-MMU-216083", "R-HSA-9860927", "R-HSA-372708", "R-GGA-9860927", "R-MMU-186797", "R-MMU-354192", "R-MMU-9860927", "R-HSA-9656223", "R-GGA-9634597", "R-MMU-114608", "R-HSA-9657688", "R-HSA-9634597", "R-GGA-3000178", "R-MMU-5674135", "R-RNO-216083", "R-HSA-9657689", "R-GGA-1474228", "R-RNO-354194", "R-SSC-186797", "R-RNO-2129379", "R-RNO-114608", "R-RNO-9860927", "R-RNO-8874081", "R-MMU-372708", "R-HSA-114608", "R-HSA-9638630", "R-MMU-8874081", "R-RNO-354192", "R-HSA-6802946", "R-RNO-8957275", "R-RNO-5674135", "R-RNO-75205", "R-GGA-381426", "R-HSA-354192", "R-HSA-9925563", "R-HSA-2129379", "R-HSA-216083", "R-HSA-3000170", "R-MMU-1566977", "R-HSA-1566977", "R-RNO-186797", "R-MMU-75205", "R-HSA-354194", "R-MMU-354194", "R-GGA-114608", "R-SSC-75205", "R-GGA-1566977", "R-MMU-6806942", "R-HSA-8957275", "R-RNO-3000170", "R-HSA-9725370", "R-HSA-202733", 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wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-GGA-3000170:r:Syndecan interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-1566977:r:Fibronectin matrix formation", "R-GGA-216083:r:Integrin cell surface interactions", "R-GGA-2129379:r:Molecules associated with elastic fibres", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-GGA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-GGA-9634597:r:GPER1 signaling", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-HSA-9634597:r:GPER1 signaling", "R-GGA-3000178:r:ECM proteoglycans", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-186797:r:Signaling by PDGF", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-RNO-114608:r:Platelet degranulation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", 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"GO:0006281", "GO:0006310"], "go_terms": ["GO:0003678:DNA helicase activity:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P"], "name": "RuvA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000086": {"description": "NUDIX hydrolase domain", "go_ids": [], "go_terms": [], "name": "NUDIX_hydrolase_dom", "pathway_ids": ["R-CFA-2393930", "R-HSA-3299685", "R-MMU-1855167", "R-DRE-77595", "R-RNO-110331", "R-BTA-73856", "R-HSA-196807", "R-MMU-73856", "R-SSC-3299685", "R-MMU-9969896", "R-RNO-110357", "R-CEL-450513", "R-MMU-3299685", "R-HSA-390918", "R-HSA-9748787", "R-MMU-450604", "R-HSA-450604", "R-BTA-9770562", "R-MMU-6798695", "R-HSA-480985", "R-RNO-6798695", "R-MMU-196807", "R-MMU-450385", "R-SPO-196807", "R-GGA-390918", "R-CEL-390918", "R-HSA-1855167", "R-BTA-2393930", "R-RNO-390918", "R-MMU-77595", "R-RNO-77595", "R-DDI-9770562", "R-HSA-199220", "R-RNO-1855167", "R-MMU-499943", "R-HSA-77595", "R-DRE-2393930", "R-CEL-2393930", "R-BTA-196807", "R-RNO-3295583", 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hydrolysis by NUDT proteins", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-9770562:r:mRNA Polyadenylation", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-196807:r:Nicotinate metabolism", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-110331:r:Cleavage of the damaged purine", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-110331:r:Cleavage of the damaged purine", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-SSC-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SPO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-BTA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-SCE-9033241:r:Peroxisomal protein import", "R-CEL-196807:r:Nicotinate metabolism", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-SCE-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-9748787:r:Azathioprine ADME"], "type": "Domain"}, "IPR000089": {"description": "Biotin/lipoyl attachment", "go_ids": [], "go_terms": [], "name": "Biotin_lipoyl", "pathway_ids": ["R-DDI-75105", "R-HSA-9853506", "R-BTA-5362517", "R-RNO-9857492", "R-MMU-70263", "R-DDI-9858328", "R-CEL-9013407", "R-HSA-70263", "R-RNO-70268", "R-BTA-204174", "R-MMU-9861559", "R-BTA-6783984", "R-DME-9857492", "R-BTA-9859138", "R-BTA-9837999", "R-SPO-200425", "R-HSA-71032", "R-DME-6783984", "R-HSA-9912481", "R-CEL-9859138", "R-SCE-200425", "R-BTA-9013407", "R-BTA-70895", "R-MMU-9013407", "R-CEL-9837999", "R-MMU-200425", "R-MMU-9857492", "R-SCE-9857492", "R-BTA-9857492", "R-HSA-9907570", "R-HSA-70895", "R-GGA-9857492", "R-BTA-196780", "R-MMU-196780", "R-HSA-9861559", "R-RNO-9858328", "R-RNO-9853506", "R-BTA-70268", "R-SPO-9857492", "R-CEL-9857492", "R-MMU-204174", "R-MMU-9859138", "R-BTA-70263", "R-HSA-75105", "R-HSA-9909438", "R-SCE-196780", "R-MMU-9858328", "R-HSA-9912529", "R-HSA-9013407", "R-SCE-70268", "R-RNO-5362517", "R-SCE-75105", "R-MMU-9837999", "R-CEL-71032", "R-SPO-9861559", "R-SPO-9853506", "R-SPO-70268", "R-DDI-70895", "R-HSA-196780", "R-GGA-6783984", "R-RNO-75105", "R-DDI-9857492", "R-DDI-200425", "R-HSA-9858328", "R-RNO-196780", "R-DDI-196780", "R-MMU-70895", "R-SPO-70263", "R-RNO-200425", "R-HSA-1222541", "R-DDI-6783984", "R-RNO-71032", "R-HSA-9837999", "R-SPO-6783984", "R-MMU-71032", "R-MMU-9853506", "R-HSA-5362517", "R-HSA-9859138", "R-RNO-9861559", "R-HSA-163765", "R-CEL-196780", "R-MMU-70268", "R-HSA-204174", "R-SPO-5362517", "R-SCE-9853506", "R-MMU-6783984", "R-RNO-204174", "R-SPO-75105", "R-BTA-9861559", "R-HSA-9865125", "R-SCE-6783984", "R-HSA-3371599", "R-MMU-75105", "R-HSA-9857492", "R-HSA-70268", "R-RNO-70895", "R-RNO-6783984", "R-SPO-196780", "R-CEL-70268", "R-DDI-9853506", "R-CEL-70263", "R-SCE-9861559", "R-HSA-200425", "R-HSA-6783984", "R-SCE-70263", "R-MMU-5362517", "R-HSA-9865113", "R-DDI-9861559", "R-HSA-2426168", "R-SPO-204174", "R-RNO-70263"], "pathways": ["R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-BTA-5362517:r:Signaling by Retinoic Acid", "R-RNO-9857492:r:Protein lipoylation", "R-MMU-70263:r:Gluconeogenesis", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-70263:r:Gluconeogenesis", "R-RNO-70268:r:Pyruvate metabolism", "R-BTA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-6783984:r:Glycine degradation", "R-DME-9857492:r:Protein lipoylation", "R-BTA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SPO-200425:r:Carnitine shuttle", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-DME-6783984:r:Glycine degradation", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-CEL-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SCE-200425:r:Carnitine shuttle", "R-BTA-9013407:r:RHOH GTPase cycle", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-MMU-200425:r:Carnitine shuttle", "R-MMU-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-BTA-9857492:r:Protein lipoylation", "R-HSA-9907570:r:Loss-of-function mutations in DLD cause MSUD3/DLDD", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-GGA-9857492:r:Protein lipoylation", "R-BTA-196780:r:Biotin transport and metabolism", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-RNO-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-BTA-70268:r:Pyruvate metabolism", "R-SPO-9857492:r:Protein lipoylation", "R-CEL-9857492:r:Protein lipoylation", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-70263:r:Gluconeogenesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9909438:r:3-Methylcrotonyl-CoA carboxylase deficiency", "R-SCE-196780:r:Biotin transport and metabolism", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SCE-70268:r:Pyruvate metabolism", "R-RNO-5362517:r:Signaling by Retinoic Acid", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-SPO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SPO-70268:r:Pyruvate metabolism", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-196780:r:Biotin transport and metabolism", "R-GGA-6783984:r:Glycine degradation", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-9857492:r:Protein lipoylation", "R-DDI-200425:r:Carnitine shuttle", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-RNO-196780:r:Biotin transport and metabolism", "R-DDI-196780:r:Biotin transport and metabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-SPO-70263:r:Gluconeogenesis", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-1222541:r:Cell redox homeostasis", "R-DDI-6783984:r:Glycine degradation", "R-RNO-71032:r:Propionyl-CoA catabolism", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-RNO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-CEL-196780:r:Biotin transport and metabolism", "R-MMU-70268:r:Pyruvate metabolism", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-6783984:r:Glycine degradation", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-9865125:r:Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD", "R-SCE-6783984:r:Glycine degradation", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9857492:r:Protein lipoylation", "R-HSA-70268:r:Pyruvate metabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-RNO-6783984:r:Glycine degradation", "R-SPO-196780:r:Biotin transport and metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-CEL-70263:r:Gluconeogenesis", "R-SCE-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-200425:r:Carnitine shuttle", "R-HSA-6783984:r:Glycine degradation", "R-SCE-70263:r:Gluconeogenesis", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-DDI-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR000090": {"description": "Flagellar motor switch protein FliG", "go_ids": ["GO:0003774", "GO:0006935", "GO:0009288", "GO:0071973"], "go_terms": ["GO:0003774:cytoskeletal motor activity:F", "GO:0006935:chemotaxis:P", "GO:0009288:bacterial-type flagellum:C", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "Flg_Motor_Flig", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000092": {"description": "Polyprenyl synthetase-like", "go_ids": ["GO:0008299", "GO:0004659"], "go_terms": ["GO:0008299:isoprenoid biosynthetic process:P", "GO:0004659:prenyltransferase activity:F"], "name": "Polyprenyl_synt", "pathway_ids": ["R-SPO-2142789", "R-SCE-9969896", "R-SCE-2142789", "R-HSA-9969896", "R-DDI-2142789", "R-HSA-2142789", "R-BTA-9969896", "R-DDI-9969896", "R-RNO-2142789", "R-MMU-9969896", "R-MMU-2142789", "R-HSA-2426168", "R-RNO-9969896", "R-SPO-9969896"], "pathways": ["R-SPO-2142789:r:Ubiquinol biosynthesis", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR000093": {"description": "DNA recombination protein RecR", "go_ids": ["GO:0003677", "GO:0006281", "GO:0006310", "GO:0046872"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0046872:metal ion binding:F"], "name": "DNA_Rcmb_RecR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000095": {"description": "CRIB domain", "go_ids": [], "go_terms": [], "name": "CRIB_dom", "pathway_ids": ["R-HSA-5663213", "R-HSA-9013409", "R-HSA-9013405", "R-CEL-3928664", "R-BTA-3928662", "R-HSA-2871796", "R-MMU-9013408", "R-RNO-202433", "R-RNO-5687128", "R-CEL-5621575", "R-MMU-445355", "R-RNO-5218920", "R-DDI-389359", "R-CEL-9013407", "R-RNO-399954", "R-HSA-5218920", "R-MMU-9013420", "R-BTA-5663213", "R-HSA-389359", "R-DME-3928664", "R-SPO-389359", "R-DDI-445144", "R-CEL-389359", "R-HSA-203641", "R-HSA-211733", "R-DME-9013149", "R-SPO-2029482", "R-MMU-9013407", "R-RNO-445144", "R-RNO-9013407", "R-DME-5627123", "R-DME-5218920", "R-MMU-9013423", "R-DME-389359", "R-HSA-211728", "R-HSA-399954", "R-SPO-5627123", "R-BTA-203641", "R-HSA-445144", "R-MMU-5627123", "R-RNO-5621575", "R-MMU-5687128", "R-RNO-9013420", "R-BTA-202433", "R-RNO-2871796", "R-BTA-2029482", "R-CEL-5687128", "R-HSA-202433", "R-BTA-9013406", "R-HSA-5625740", "R-CEL-983168", "R-BTA-8964616", "R-MMU-8964616", "R-BTA-9013423", "R-HSA-9013423", "R-SPO-9013406", "R-SCE-3928662", "R-RNO-389359", "R-RNO-445355", "R-HSA-9013148", "R-RNO-3928662", "R-CEL-9013406", "R-SPO-9013420", "R-MMU-3928664", "R-CEL-9013423", "R-DDI-2029482", "R-BTA-8856828", "R-DDI-5687128", "R-BTA-3928664", "R-MMU-9013424", "R-BTA-5218920", "R-BTA-418885", "R-RNO-3928664", "R-RNO-9013423", "R-DDI-3928662", "R-BTA-9013404", "R-CEL-9013420", "R-HSA-428540", "R-SCE-389359", "R-DDI-9013404", "R-MMU-9013149", "R-CEL-8951664", "R-DME-9013420", "R-RNO-5627123", "R-MMU-389359", "R-BTA-9013424", "R-HSA-8856828", "R-BTA-373753", "R-DME-5621575", "R-CEL-9013424", "R-RNO-9013149", "R-DME-8964616", "R-HSA-9013424", "R-MMU-9013404", "R-MMU-4420097", "R-HSA-3928662", "R-MMU-2871796", "R-HSA-4420097", "R-BTA-389359", "R-DME-2029482", "R-RNO-9013424", "R-MMU-399954", "R-CEL-8964616", "R-HSA-164944", "R-SCE-9013420", "R-RNO-9013404", "R-RNO-9013406", "R-RNO-9013408", "R-CEL-3928662", "R-HSA-9013408", "R-DDI-9013423", "R-HSA-373753", "R-BTA-9013407", "R-MMU-5621575", "R-HSA-3928664", 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transduction by L1", "R-CEL-389359:r:CD28 dependent Vav1 pathway", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DME-9013149:r:RAC1 GTPase cycle", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-9013407:r:RHOH GTPase cycle", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-DME-389359:r:CD28 dependent Vav1 pathway", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-BTA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-BTA-202433:r:Generation of second messenger molecules", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-RNO-445355:r:Smooth Muscle Contraction", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-3928664:r:Ephrin signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-BTA-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-418885:r:DCC mediated attractive signaling", "R-RNO-3928664:r:Ephrin signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-CEL-9013420:r:RHOU GTPase cycle", "R-HSA-428540:r:Activation of RAC1", "R-SCE-389359:r:CD28 dependent Vav1 pathway", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-8951664:r:Neddylation", "R-DME-9013420:r:RHOU GTPase cycle", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-BTA-9013424:r:RHOV GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-373753:r:Nephrin family interactions", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9013424:r:RHOV GTPase cycle", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-164944:r:Nef and signal transduction", "R-SCE-9013420:r:RHOU GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-373753:r:Nephrin family interactions", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-3928664:r:Ephrin signaling", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445144:r:Signal transduction by L1", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-445355:r:Smooth Muscle Contraction", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CEL-5627123:r:RHO GTPases activate PAKs", "R-DME-445144:r:Signal transduction by L1", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-445144:r:Signal transduction by L1", "R-SPO-9013424:r:RHOV GTPase cycle", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-HSA-418885:r:DCC mediated attractive signaling", "R-DME-9013424:r:RHOV GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-HSA-211736:r:Stimulation of the cell death response by PAK-2p34", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-DME-9013406:r:RHOQ GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-DME-9013407:r:RHOH GTPase cycle", "R-BTA-9013420:r:RHOU GTPase cycle", "R-MMU-202433:r:Generation of second messenger molecules", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-445355:r:Smooth Muscle Contraction", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-BTA-9013408:r:RHOG GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DME-9013423:r:RAC3 GTPase cycle", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Domain"}, "IPR000096": {"description": "Serum amyloid A protein", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Serum_amyloid_A", "pathway_ids": ["R-HSA-418594", "R-HSA-879415", "R-HSA-3000471", "R-HSA-444473", "R-HSA-933542", "R-HSA-977225", "R-HSA-416476", "R-HSA-6785807", "R-HSA-445989"], "pathways": ["R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation"], "type": "Family"}, "IPR000100": {"description": "Ribonuclease P", "go_ids": ["GO:0000049", "GO:0004526", "GO:0008033"], "go_terms": ["GO:0000049:tRNA binding:F", "GO:0004526:ribonuclease P activity:F", "GO:0008033:tRNA processing:P"], "name": "RNase_P", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000101": {"description": "Gamma-glutamyltranspeptidase", "go_ids": ["GO:0036374", "GO:0006751"], "go_terms": ["GO:0036374:glutathione gamma-glutamate hydrolase:F", "GO:0006751:glutathione catabolic process:P"], "name": "GGT_peptidase", "pathway_ids": ["PWY-8301", "PWY-5826", "PWY-8001", "PWY-7559", "PWY-4061", "PWY-6842", "PWY-7112", "PWY-4041", "PWY-8355", "R-HSA-2142691", "R-SPO-2142691", "R-MMU-9753281", "R-RNO-174403", "R-RNO-9753281", "R-SPO-5423646", "R-RNO-5423646", "R-HSA-5423646", "R-HSA-9753281", "R-SCE-174403", "R-MMU-5423646", "R-SCE-5423646", "R-RNO-2142691", "R-HSA-5579022", "R-BTA-5423646", "R-BTA-174403", "R-MMU-174403", "R-SPO-174403", "R-SCE-2142691", "R-MMU-2142691", "R-HSA-9664535", "R-SPO-9753281", "R-HSA-9035968", "R-SCE-9753281", "R-HSA-174403", "R-BTA-9753281"], "pathways": ["PWY-8301:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis", "PWY-5826:t:hypoglycin biosynthesis", "PWY-8001:t:felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis", "PWY-7559:t:glutathione degradation (DUG pathway)", "PWY-4061:t:glutathione-mediated detoxification I", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-7112:t:4-hydroxy-2-nonenal detoxification", "PWY-4041:t:gamma-glutamyl cycle", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9753281:r:Paracetamol ADME", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-RNO-9753281:r:Paracetamol ADME", "R-SPO-5423646:r:Aflatoxin activation and detoxification", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-HSA-9753281:r:Paracetamol ADME", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-SCE-5423646:r:Aflatoxin activation and detoxification", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-5579022:r:Defective GGT1 causes GLUTH", "R-BTA-5423646:r:Aflatoxin activation and detoxification", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9664535:r:LTC4-CYSLTR mediated IL4 production", "R-SPO-9753281:r:Paracetamol ADME", "R-HSA-9035968:r:Defective GGT1 in aflatoxin detoxification causes GLUTH", "R-SCE-9753281:r:Paracetamol ADME", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-BTA-9753281:r:Paracetamol ADME"], "type": "Family"}, "IPR000102": {"description": "Neuraxin/MAP1B repeat", "go_ids": [], "go_terms": [], "name": "MAP1B_neuraxin", "pathway_ids": ["R-HSA-9833110"], "pathways": ["R-HSA-9833110:r:RSV-host interactions"], "type": "Repeat"}, "IPR000109": {"description": "Proton-dependent oligopeptide transporter family", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "POT_fam", "pathway_ids": ["R-HSA-6798695", "R-HSA-9860276", "R-SCE-427975", "R-RNO-9860276", "R-DME-427975", "R-SPO-427975", "R-MMU-427975", "R-CEL-427975", "R-MMU-6798695", "R-BTA-9860276", "R-BTA-6798695", "R-BTA-427975", "R-HSA-427975", "R-MMU-9860276", "R-RNO-6798695", "R-RNO-427975"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-SCE-427975:r:Proton/oligopeptide cotransporters", "R-RNO-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-DME-427975:r:Proton/oligopeptide cotransporters", "R-SPO-427975:r:Proton/oligopeptide cotransporters", "R-MMU-427975:r:Proton/oligopeptide cotransporters", "R-CEL-427975:r:Proton/oligopeptide cotransporters", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-427975:r:Proton/oligopeptide cotransporters", "R-HSA-427975:r:Proton/oligopeptide cotransporters", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-427975:r:Proton/oligopeptide cotransporters"], "type": "Family"}, "IPR000110": {"description": "Small ribosomal subunit protein bS1", "go_ids": ["GO:0003723", "GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000114": {"description": "Large ribosomal subunit protein uL16, bacteria", "go_ids": ["GO:0003735", "GO:0006412", "GO:0019843"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0006412:translation:P", "GO:0019843:rRNA binding:F"], "name": "Ribosomal_uL16_bact", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-MMU-5389840", "R-HSA-5389840", "R-BTA-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR000115": {"description": "Phosphoribosylglycinamide synthetase", "go_ids": ["GO:0004637", "GO:0009113"], "go_terms": ["GO:0004637:phosphoribosylamine-glycine ligase activity:F", "GO:0009113:purine nucleobase biosynthetic process:P"], "name": "PRibGlycinamide_synth", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-BTA-73817", "R-MMU-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817", "R-GGA-419140"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Family"}, "IPR000117": {"description": "Kappa casein", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Casein_kappa", "pathway_ids": ["R-HSA-5223345", "R-RNO-5223345", "R-MMU-5223345", "R-SSC-5223345"], "pathways": ["R-HSA-5223345:r:Miscellaneous transport and binding events", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-SSC-5223345:r:Miscellaneous transport and binding events"], "type": "Family"}, "IPR000118": {"description": "Granulin", "go_ids": [], "go_terms": [], "name": "Granulin", "pathway_ids": ["R-MMU-6798695", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR000119": {"description": "Histone-like DNA-binding protein", "go_ids": ["GO:0003677", "GO:0030527"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0030527:structural constituent of chromatin:F"], "name": "Hist_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000120": {"description": "Amidase", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Amidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000121": {"description": "PEP-utilising enzyme, C-terminal", "go_ids": ["GO:0016310", "GO:0016772"], "go_terms": ["GO:0016310:phosphorylation:P", "GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "PEP_util_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000125": {"description": "Glycoside hydrolase, family 14A, bacterial", "go_ids": ["GO:0005976", "GO:0016161"], "go_terms": ["GO:0005976:polysaccharide metabolic process:P", "GO:0016161:beta-amylase activity:F"], "name": "Glyco_hydro_14A_bac", "pathway_ids": ["PWY-6724", "PWY-842"], "pathways": ["PWY-6724:t:starch degradation II", "PWY-842:t:starch degradation I"], "type": "Family"}, "IPR000128": {"description": "Progesterone receptor", "go_ids": ["GO:0003677", "GO:0003707", "GO:0005496", "GO:0005634", "GO:0006355", "GO:0043401"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003707:nuclear steroid receptor activity:F", "GO:0005496:steroid binding:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0043401:steroid hormone receptor signaling pathway:P"], "name": "Progest_rcpt", "pathway_ids": ["R-GGA-3371497", "R-HSA-1251985", "R-GGA-4090294", "R-RNO-3371497", "R-HSA-3371497", "R-GGA-9018519", "R-HSA-9927418", "R-RNO-9018519", "R-GGA-383280", "R-MMU-9018519", "R-HSA-383280", "R-MMU-383280", "R-RNO-383280", "R-HSA-4090294", "R-MMU-4090294", "R-RNO-4090294", "R-HSA-9018519", "R-MMU-3371497", "R-HSA-9927426"], "pathways": ["R-GGA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-GGA-4090294:r:SUMOylation of intracellular receptors", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-GGA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-GGA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Family"}, "IPR000131": {"description": "ATP synthase, F1 complex, gamma subunit", "go_ids": ["GO:0015986", "GO:0046933", "GO:0045259"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P", "GO:0046933:proton-transporting ATP synthase activity, rotational mechanism:F", "GO:0045259:proton-transporting ATP synthase complex:C"], "name": "ATP_synth_F1_gsu", "pathway_ids": ["R-DDI-9837999", "R-MMU-9837999", "R-BTA-8949613", "R-SPO-9837999", "R-BTA-9837999", "R-HSA-8949613", "R-DME-9837999", "R-SCE-9837999", "R-MMU-163210", "R-DME-163210", "R-BTA-163210", "R-HSA-9837999", "R-RNO-163210", "R-RNO-8949613", "R-RNO-9837999", "R-MMU-8949613", "R-DME-8949613", "R-HSA-163210"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-8949613:r:Cristae formation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-8949613:r:Cristae formation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-8949613:r:Cristae formation", "R-DME-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR000133": {"description": "ER lumen protein retaining receptor", "go_ids": ["GO:0006621", "GO:0046923", "GO:0016020"], "go_terms": ["GO:0006621:protein retention in ER lumen:P", "GO:0046923:ER lumen protein retrieval receptor activity:F", "GO:0016020:membrane:C"], "name": "ER_ret_rcpt", "pathway_ids": ["R-SPO-6807878", "R-HSA-381038", "R-SCE-6807878", "R-RNO-6811434", "R-SCE-6811434", "R-RNO-6807878", "R-XTR-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-DDI-6811434", "R-PFA-6811434", "R-CEL-6811434", "R-DME-6811434", "R-BTA-6807878", "R-HSA-6811434", "R-XTR-6811434", "R-DRE-6811434", "R-DDI-6807878", "R-HSA-9918476", "R-SPO-6811434", "R-DRE-6807878", "R-DME-6807878", "R-BTA-6811434", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-XTR-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-PFA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR000136": {"description": "Oleosin", "go_ids": ["GO:0012511", "GO:0016020"], "go_terms": ["GO:0012511:monolayer-surrounded lipid storage body:C", "GO:0016020:membrane:C"], "name": "Oleosin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000145": {"description": "Outer capsid protein VP5, Orbivirus", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Capsid_VP5_Orbivir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000146": {"description": "Fructose-1,6-bisphosphatase class 1", "go_ids": ["GO:0005975", "GO:0016791"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016791:phosphatase activity:F"], "name": "FBPase_class-1", "pathway_ids": ["PWY-5484", "R-HSA-70263", "R-BTA-70263", "R-SSC-70263", "R-SPO-70263", "R-SCE-70263", "R-MMU-70263", "R-DDI-70263", "R-RNO-70263"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-HSA-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SSC-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Family"}, "IPR000148": {"description": "Papillomavirus E7", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Papilloma_E7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000150": {"description": "Cof family", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Cof", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR000151": {"description": "Ciliary neurotrophic factor, CNTF", "go_ids": ["GO:0043524", "GO:0070120", "GO:0005127"], "go_terms": ["GO:0043524:negative regulation of neuron apoptotic process:P", "GO:0070120:ciliary neurotrophic factor-mediated signaling pathway:P", "GO:0005127:ciliary neurotrophic factor receptor binding:F"], "name": "Ciliary_neurotrophic_fac_CNTF", "pathway_ids": ["R-MMU-6788467", "R-GGA-6788467", "R-HSA-6788467", "R-RNO-6788467", "R-SSC-6788467"], "pathways": ["R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Family"}, "IPR000153": {"description": "Reovirus, outer capsid sigma 3", "go_ids": ["GO:0005198", "GO:0019058"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019058:viral life cycle:P"], "name": "Reo_capsid_sigma3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000156": {"description": "Ran binding domain", "go_ids": ["GO:0046907"], "go_terms": ["GO:0046907:intracellular transport:P"], "name": "Ran_bind_dom", "pathway_ids": ["R-DME-159230", "R-RNO-4551638", "R-DME-3301854", "R-RNO-170822", "R-RNO-159231", "R-HSA-5663220", "R-HSA-180746", "R-HSA-9725370", "R-HSA-180910", "R-MMU-2467813", "R-RNO-3301854", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-68877", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-RNO-191859", "R-HSA-3371453", "R-DME-4615885", "R-HSA-4570464", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-DME-3371453", "R-MMU-141444", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-HSA-141444", "R-DME-159227", "R-HSA-168325", "R-HSA-9648025", "R-MMU-170822", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-RNO-4085377", "R-SPO-4570464", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-MMU-5663220", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-191859", "R-HSA-2467813", "R-HSA-3108214", "R-HSA-9705671", "R-SPO-159227", "R-SPO-159231", "R-MMU-3232142", "R-DME-159236", "R-DME-159231", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-HSA-168333", "R-MMU-4085377", "R-HSA-68877", "R-HSA-165054", "R-RNO-159236", "R-HSA-4615885", "R-MMU-9648025", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-MMU-2500257", "R-HSA-2500257", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-DME-4551638", "R-HSA-4085377", "R-RNO-159227"], "pathways": ["R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-191859:r:snRNP Assembly", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-191859:r:snRNP Assembly", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-191859:r:snRNP Assembly", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA"], "type": "Domain"}, "IPR000157": {"description": "Toll/interleukin-1 receptor homology (TIR) domain", "go_ids": ["GO:0007165"], "go_terms": ["GO:0007165:signal transduction:P"], "name": "TIR_dom", "pathway_ids": ["R-HSA-9020702", "R-SSC-1679131", "R-MMU-6811558", "R-BTA-166166", "R-MMU-9020702", "R-MMU-937072", "R-MMU-9014843", "R-SSC-109704", "R-MMU-3134963", "R-XTR-209543", "R-HSA-3134963", "R-RNO-6811558", "R-HSA-168927", "R-MMU-9707616", "R-DME-214869", "R-MMU-1810476", "R-HSA-937041", "R-DME-214842", "R-BTA-936964", "R-GGA-517856", "R-HSA-5602415", "R-MMU-1679131", "R-RNO-5686938", "R-HSA-168138", "R-MMU-9007892", "R-RNO-2562578", "R-HSA-983695", "R-BTA-168142", "R-GGA-5686938", "R-DME-214862", "R-RNO-975163", "R-HSA-975163", "R-RNO-936964", "R-MMU-5686938", "R-HSA-5602680", "R-RNO-209543", "R-HSA-9820960", "R-HSA-9008059", "R-DME-214874", "R-RNO-388844", "R-HSA-1236974", "R-DME-9010553", "R-HSA-168164", "R-HSA-9705671", "R-RNO-937072", "R-SSC-168138", "R-RNO-1257604", "R-HSA-9824878", "R-DME-214863", "R-HSA-168179", "R-RNO-3134963", "R-MMU-166166", "R-MMU-388844", "R-GGA-451514", "R-HSA-388844", "R-HSA-9824856", "R-RNO-9707616", "R-HSA-5686938", "R-DME-376176", "R-MMU-9824878", "R-MMU-936964", "R-RNO-937041", "R-DDI-9833482", "R-HSA-975871", "R-MMU-109704", "R-DDI-936440", "R-HSA-109704", "R-HSA-5602566", "R-HSA-9707616", "R-MMU-1257604", "R-HSA-168142", "R-RNO-9824878", "R-HSA-5603037", "R-HSA-9014843", "R-HSA-5602498", "R-MMU-2562578", "R-HSA-140534", "R-MMU-168138", "R-RNO-166016", "R-MMU-937041", "R-BTA-2562578", "R-HSA-6798695", "R-GGA-433822", "R-RNO-9020702", "R-HSA-9828211", "R-HSA-166016", "R-MMU-9012546", "R-BTA-6798695", "R-RNO-9014843", "R-BTA-9824878", "R-BTA-140534", "R-HSA-936964", "R-BTA-937041", "R-RNO-140534", "R-HSA-9007892", "R-MMU-975163", "R-HSA-168176", "R-DME-214844", "R-HSA-1461957", "R-HSA-6783783", "R-MMU-140534", "R-HSA-166058", "R-RNO-9014826", "R-DRE-9007892", "R-MMU-209543", "R-MMU-166016", "R-GGA-1461957", "R-MMU-1461957", "R-HSA-2219530", "R-CFA-168138", "R-GGA-6798695", "R-BTA-166016", "R-HSA-6811558", "R-HSA-9014826", "R-DRE-209543", "R-HSA-9012546", "R-HSA-5603041", "R-MMU-6798695", "R-HSA-975110", "R-HSA-1257604", "R-HSA-9013957", "R-HSA-168188", "R-GGA-983695", "R-HSA-975138", "R-HSA-5602571", "R-GGA-573298", "R-HSA-209543", "R-XTR-3134963", "R-BTA-937072", "R-RNO-166166", "R-HSA-5602410", "R-HSA-168181", "R-MMU-9014826", "R-GGA-6811558", "R-MMU-168181", "R-GGA-451477", "R-HSA-9833110", "R-XTR-9020702", "R-DME-428890", "R-HSA-937072", "R-HSA-9918481", "R-RNO-1810476", "R-GGA-1257604", "R-DDI-1169408", "R-HSA-9013973", "R-MMU-166058", "R-HSA-9679191", "R-MMU-983695", "R-CFA-109704", "R-HSA-166166", "R-HSA-975155", "R-HSA-1810476", "R-HSA-1679131", "R-DDI-983168", "R-RNO-9007892", "R-HSA-2562578", "R-DDI-9909505", "R-CFA-1679131", "R-HSA-9692916", "R-GGA-977240", "R-HSA-9014325", "R-BTA-975163", "R-HSA-9637628", "R-DME-209442"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-SSC-1679131:r:Trafficking and processing of endosomal TLR", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-166166:r:MyD88-independent TLR4 cascade", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-9014843:r:Interleukin-33 signaling", "R-SSC-109704:r:PI3K Cascade", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-XTR-209543:r:p75NTR recruits signalling complexes", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-MMU-9707616:r:Heme signaling", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-517856:r:TLR2 subfamily cascade", "R-HSA-5602415:r:UNC93B1 deficiency - HSE", "R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-9007892:r:Interleukin-38 signaling", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-GGA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-9008059:r:Interleukin-37 signaling", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-GGA-451514:r:MyD88:TIRAP-dependent cascade initiated on plasma membrane", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9824856:r:Defective regulation of TLR7 by endogenous ligand", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-376176:r:Signaling by ROBO receptors", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-DDI-9833482:r:PKR-mediated signaling", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-109704:r:PI3K Cascade", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-109704:r:PI3K Cascade", "R-HSA-5602566:r:TICAM1 deficiency - HSE", "R-HSA-9707616:r:Heme signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-RNO-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-HSA-9014843:r:Interleukin-33 signaling", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-2562578:r:TRIF-mediated programmed cell death", "R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-9012546:r:Interleukin-18 signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-9014843:r:Interleukin-33 signaling", "R-BTA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-9007892:r:Interleukin-38 signaling", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-HSA-1461957:r:Beta defensins", "R-HSA-6783783:r:Interleukin-10 signaling", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-9014826:r:Interleukin-36 pathway", "R-DRE-9007892:r:Interleukin-38 signaling", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-GGA-1461957:r:Beta defensins", "R-MMU-1461957:r:Beta defensins", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-CFA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9014826:r:Interleukin-36 pathway", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-HSA-9012546:r:Interleukin-18 signaling", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-HSA-168188:r:Toll Like Receptor TLR6:TLR2 Cascade", "R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-GGA-573298:r:NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-XTR-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-166166:r:MyD88-independent TLR4 cascade", "R-HSA-5602410:r:TLR3 deficiency - HSE", "R-HSA-168181:r:Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-MMU-9014826:r:Interleukin-36 pathway", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-168181:r:Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-GGA-451477:r:MyD88-dependent cascade initiated on endosome membrane", "R-HSA-9833110:r:RSV-host interactions", "R-XTR-9020702:r:Interleukin-1 signaling", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CFA-109704:r:PI3K Cascade", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9007892:r:Interleukin-38 signaling", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CFA-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-GGA-977240:r:MyD88 cascade initiated on plasma membrane", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'"], "type": "Domain"}, "IPR000158": {"description": "Cell division protein FtsZ", "go_ids": ["GO:0003924", "GO:0005525"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005525:GTP binding:F"], "name": "Cell_div_FtsZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000159": {"description": "Ras-associating domain", "go_ids": ["GO:0007165"], "go_terms": ["GO:0007165:signal transduction:P"], "name": "RA_dom", "pathway_ids": ["R-RNO-9013026", "R-HSA-8849469", "R-HSA-1989781", "R-HSA-9607240", "R-RNO-1306955", "R-HSA-5674135", "R-MMU-9607240", "R-DRE-5674135", "R-BTA-9696273", "R-SSC-9607240", "R-MMU-1306955", "R-HSA-6802952", "R-BTA-5673001", "R-SPO-5223345", "R-CEL-354194", "R-MMU-9013106", "R-RNO-9607240", "R-RNO-74749", "R-MMU-210993", "R-RNO-9013149", "R-HSA-9013424", "R-HSA-1306955", "R-CEL-5673001", "R-DRE-5673001", "R-SPO-9013106", "R-HSA-418990", "R-HSA-8853659", "R-BTA-8853659", "R-HSA-9649948", "R-RNO-9013424", "R-CFA-5673001", "R-MMU-74751", "R-RNO-5673001", "R-MMU-5673001", "R-MMU-186763", "R-HSA-6802955", "R-CEL-1855204", "R-MMU-9035034", "R-SSC-74749", "R-MMU-1433557", "R-RNO-210993", "R-HSA-74713", "R-HSA-210993", "R-RNO-8853659", "R-HSA-6802948", "R-MMU-8853659", "R-HSA-2029482", "R-HSA-8876198", "R-CEL-5674135", "R-RNO-9013148", "R-HSA-373752", "R-RNO-9696273", "R-DRE-354192", "R-HSA-5673001", "R-RNO-1433557", "R-SPO-8980692", "R-SPO-9652282", "R-HSA-9648895", "R-MMU-171007", "R-HSA-8980692", "R-HSA-9013149", "R-MMU-8876198", "R-MMU-9013423", "R-MMU-9013149", "R-HSA-1855204", "R-DRE-354194", "R-HSA-9013026", "R-DRE-9013026", "R-DRE-8980692", "R-HSA-372708", "R-SSC-1433557", "R-MMU-354192", "R-HSA-9656223", "R-MMU-5674135", "R-HSA-74751", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-418990", "R-RNO-8876198", "R-HSA-9013106", "R-MMU-9013148", "R-RNO-2029482", "R-BTA-186763", "R-HSA-9013423", "R-MMU-372708", "R-HSA-114508", "R-HSA-6802946", "R-HSA-9035034", "R-CEL-354192", "R-HSA-9013148", "R-SPO-983168", "R-RNO-8985586", "R-RNO-9013106", "R-RNO-114508", "R-SSC-8853659", "R-SPO-6803207", "R-MMU-1855204", "R-HSA-171007", "R-BTA-1433557", "R-BTA-1306955", "R-HSA-354192", "R-MMU-114508", "R-MMU-74713", "R-RNO-171007", "R-MMU-8849469", "R-DME-8876198", "R-DRE-9013424", "R-MMU-9013424", "R-HSA-354194", "R-MMU-354194", "R-MMU-8985586", "R-HSA-1433557", "R-HSA-74749", "R-DDI-264876", "R-MMU-2029482", "R-RNO-74713", "R-MMU-418990", "R-HSA-186763", "R-HSA-8985586", "R-RNO-74751", "R-SSC-74713", "R-MMU-9013026", "R-SPO-199418", "R-RNO-1855204", "R-BTA-210993", "R-SSC-74751", "R-MMU-9696273", "R-HSA-9664422", "R-MMU-74749", "R-RNO-186763", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-9607240:r:FLT3 Signaling", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-BTA-9696273:r:RND1 GTPase cycle", "R-SSC-9607240:r:FLT3 Signaling", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-SPO-5223345:r:Miscellaneous transport and binding events", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9607240:r:FLT3 Signaling", "R-RNO-74749:r:Signal attenuation", "R-MMU-210993:r:Tie2 Signaling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-418990:r:Adherens junctions interactions", "R-HSA-8853659:r:RET signaling", "R-BTA-8853659:r:RET signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-RNO-9013424:r:RHOV GTPase cycle", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-9035034:r:RHOF GTPase cycle", "R-SSC-74749:r:Signal attenuation", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-74713:r:IRS activation", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-8853659:r:RET signaling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-8853659:r:RET signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-9696273:r:RND1 GTPase cycle", "R-DRE-354192:r:Integrin signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-MMU-171007:r:p38MAPK events", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on 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Degradation of Phosphorylated Cdc25A"], "type": "Domain"}, "IPR000183": {"description": "Ornithine/DAP/Arg decarboxylase", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Orn/DAP/Arg_de-COase", "pathway_ids": ["R-CEL-351143", "R-HSA-351143", "R-SPO-351143", "R-SPO-351202", "R-DME-351143", "R-CEL-351202", "R-SPO-350562", "R-MMU-350562", "R-RNO-351143", "R-BTA-350562", "R-DME-350562", "R-HSA-351202", "R-DME-351202", "R-RNO-351202", "R-RNO-350562", "R-DDI-351202", "R-MMU-351143", "R-SCE-351143", "R-DDI-351143", "R-MMU-351202", "R-SCE-351202", "R-CEL-350562", "R-HSA-350562", "R-BTA-351202"], "pathways": ["R-CEL-351143:r:Agmatine biosynthesis", "R-HSA-351143:r:Agmatine biosynthesis", "R-SPO-351143:r:Agmatine biosynthesis", "R-SPO-351202:r:Metabolism of polyamines", "R-DME-351143:r:Agmatine biosynthesis", "R-CEL-351202:r:Metabolism of polyamines", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-350562:r:Regulation of ornithine 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lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-3371568:r:Attenuation phase", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) 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Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-XTR-9035034:r:RHOF GTPase cycle", "R-RNO-180292:r:GAB1 signalosome", "R-MMU-112399:r:IRS-mediated signalling", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9696270:r:RND2 GTPase cycle", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle", 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"R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-201556:r:Signaling by ALK", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DME-8980692:r:RHOA GTPase cycle", "R-RNO-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-RNO-9696273:r:RND1 GTPase cycle", "R-BTA-912631:r:Regulation of signaling by CBL", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-BTA-416476:r:G alpha (q) signalling events", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-CFA-9013106:r:RHOC GTPase cycle", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-SPO-9013424:r:RHOV GTPase cycle", "R-BTA-114604:r:GPVI-mediated activation cascade"], "type": "Domain"}, "IPR000199": {"description": "Peptidase C3A/C3B, picornaviral", "go_ids": ["GO:0004197", "GO:0006508"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_C3A/C3B_picornavir", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR000200": {"description": "Peptidase C10, streptopain", "go_ids": ["GO:0006508", "GO:0008234"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008234:cysteine-type peptidase activity:F"], "name": "Peptidase_C10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000201": {"description": "Hepadnaviral P protein, N-terminal", "go_ids": ["GO:0003677", "GO:0003887", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P"], "name": "DNApol_viral_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000203": {"description": "GPS motif", "go_ids": [], "go_terms": [], "name": "GPS", "pathway_ids": ["R-HSA-6798695", "R-DME-350379", "R-HSA-373080", "R-DRE-9619665", "R-MMU-5620916", "R-CEL-373080", "R-CEL-9619665", "R-DME-6798695", "R-CEL-6798695", "R-DME-9619665", "R-DME-373080", "R-HSA-9619665", "R-DME-350368", "R-DME-350480", "R-MMU-373080", "R-RNO-5683826", "R-DME-350376", "R-HSA-5620916", "R-HSA-5683826", "R-DME-350411", "R-MMU-6798695", "R-RNO-373080", "R-MMU-9619665", "R-DME-450728", "R-MMU-5683826"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-DRE-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-373080:r:Class B/2 (Secretin family receptors)", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-RNO-5683826:r:Surfactant metabolism", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-5683826:r:Surfactant metabolism", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-5683826:r:Surfactant metabolism"], "type": "Conserved_site"}, "IPR000206": {"description": "Large ribosomal subunit protein bL12", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bL12", "pathway_ids": ["R-BTA-5389840", "R-MMU-9837999", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9837999", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-MMU-9837999:r:Mitochondrial protein degradation", 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and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR000209": {"description": "Peptidase S8/S53 domain", "go_ids": ["GO:0006508", "GO:0008236"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008236:serine-type peptidase activity:F"], "name": "Peptidase_S8/S53_dom", "pathway_ids": ["PWY-7884", "R-HSA-186797", "R-CEL-1592389", "R-DME-2173789", "R-DDI-983170", "R-HSA-159782", "R-HSA-171286", "R-HSA-8963889", "R-HSA-264876", "R-HSA-9918485", "R-RNO-381033", "R-CEL-1566948", "R-RNO-8964038", "R-MMU-8957275", "R-MMU-422085", "R-MMU-1912420", "R-HSA-9828806", "R-DDI-193368", "R-MMU-381426", "R-RNO-8963889", "R-RNO-422085", "R-HSA-5210891", "R-MMU-1655829", "R-MMU-1566948", "R-RNO-9768727", "R-HSA-209952", "R-RNO-8866427", "R-HSA-381426", "R-HSA-2173789", "R-MMU-381033", "R-MMU-1592389", "R-MMU-2173796", "R-CEL-2173796", "R-HSA-9694614", "R-DME-1592389", "R-RNO-1566948", "R-HSA-422085", "R-RNO-8874211", "R-HSA-381033", "R-HSA-9820960", 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defense", "R-DME-186797:r:Signaling by PDGF"], "type": "Domain"}, "IPR000210": {"description": "BTB/POZ domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "BTB/POZ_dom", "pathway_ids": ["R-BTA-983168", "R-HSA-9013405", "R-DME-1296072", "R-DRE-4641258", "R-MMU-5632684", "R-HSA-9013422", "R-HSA-9013418", "R-RNO-5576894", "R-CEL-5632684", "R-HSA-8951664", "R-HSA-5689880", "R-DME-8951664", "R-DRE-5632684", "R-DRE-8951664", "R-HSA-8866904", "R-MMU-9706019", "R-DDI-114608", "R-MMU-381676", "R-MMU-8951664", "R-MMU-5689880", "R-BTA-9929491", "R-MMU-9013422", "R-RNO-8866904", "R-MMU-9707616", "R-MMU-3232118", "R-MMU-9929491", "R-DDI-9013423", "R-MMU-5693568", "R-DRE-9696270", "R-HSA-9614657", "R-HSA-9018519", "R-HSA-9708530", "R-GGA-9696264", "R-RNO-4641258", "R-HSA-8931987", "R-HSA-9929491", "R-BTA-5576894", "R-XTR-9929491", "R-HSA-9755511", "R-HSA-9764725", "R-HSA-6785807", "R-DME-5576890", "R-CEL-9929491", "R-HSA-4641258", "R-HSA-6783310", "R-RNO-5689880", "R-MMU-9708530", "R-HSA-9696264", "R-MMU-6811440", "R-DRE-9755511", "R-MMU-4641258", "R-HSA-5658442", "R-GGA-1296072", "R-HSA-381676", "R-RNO-8951664", "R-HSA-3232118", "R-RNO-9696264", "R-GGA-3232118", "R-MMU-9696264", "R-RNO-983168", "R-MMU-9013418", "R-MMU-114608", "R-HSA-9818027", "R-RNO-5576890", "R-HSA-5576890", "R-BTA-8951664", "R-DME-9933946", "R-DME-983168", "R-GGA-983168", "R-MMU-5576890", "R-BTA-1296072", "R-DRE-114608", "R-XTR-5632684", "R-RNO-9696270", "R-SSC-9755511", "R-DME-8866904", "R-GGA-8951664", "R-DME-5576894", "R-HSA-6803205", "R-SSC-8951664", "R-DME-9934037", "R-MMU-9755511", "R-HSA-6811440", "R-CEL-983168", "R-RNO-114608", "R-DRE-983168", "R-DRE-9929491", "R-HSA-114608", "R-BTA-114608", "R-DRE-9696264", "R-HSA-9013148", "R-HSA-9759194", "R-XTR-9696264", "R-SSC-5689880", "R-DME-9929491", "R-GGA-9696270", "R-DME-216167", "R-DME-381676", "R-DME-210671", "R-HSA-5693568", "R-MMU-1296072", "R-DRE-5689880", "R-MMU-5576894", "R-BTA-5632684", "R-HSA-381038", "R-HSA-9696270", "R-HSA-9706019", "R-MMU-3899300", "R-RNO-9755511", "R-HSA-9707616", "R-HSA-9679191", "R-HSA-983168", "R-RNO-1296072", "R-RNO-381676", "R-GGA-381676", "R-CEL-381676", "R-HSA-5632684", "R-MMU-6783310", "R-DME-5632684", "R-HSA-9707587", "R-MMU-983168", "R-HSA-1296072", "R-MMU-8866904", "R-HSA-5576894", "R-HSA-3899300", "R-MMU-9696270", "R-CEL-8951664"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DME-1296072:r:Voltage gated Potassium channels", "R-DRE-4641258:r:Degradation of DVL", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-8951664:r:Neddylation", "R-DRE-5632684:r:Hedgehog 'on' state", "R-DRE-8951664:r:Neddylation", "R-HSA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-DDI-114608:r:Platelet degranulation", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-MMU-9707616:r:Heme signaling", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-GGA-9696264:r:RND3 GTPase cycle", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-XTR-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5576890:r:Phase 3 - rapid repolarisation", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-GGA-1296072:r:Voltage gated Potassium channels", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-8951664:r:Neddylation", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-RNO-9696264:r:RND3 GTPase cycle", "R-GGA-3232118:r:SUMOylation of transcription factors", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-RNO-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-BTA-8951664:r:Neddylation", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-DRE-114608:r:Platelet degranulation", "R-XTR-5632684:r:Hedgehog 'on' state", "R-RNO-9696270:r:RND2 GTPase cycle", "R-SSC-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-GGA-8951664:r:Neddylation", "R-DME-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-SSC-8951664:r:Neddylation", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-114608:r:Platelet degranulation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DRE-9696264:r:RND3 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-XTR-9696264:r:RND3 GTPase cycle", "R-SSC-5689880:r:Ub-specific processing proteases", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-9696270:r:RND2 GTPase cycle", "R-DME-216167:r:Nuclear CI is degraded", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DME-210671:r:Transcriptional repression by nuclear factors", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-1296072:r:Voltage gated Potassium channels", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-BTA-5632684:r:Hedgehog 'on' state", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9707616:r:Heme signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-GGA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-9707587:r:Regulation of HMOX1 expression and activity", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-MMU-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-HSA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9696270:r:RND2 GTPase cycle", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR000211": {"description": "Geminivirus BL1 movement protein", "go_ids": ["GO:0033644", "GO:0046740", "GO:0003677"], "go_terms": ["GO:0033644:host cell membrane:C", "GO:0046740:transport of virus in host, cell to cell:P", "GO:0003677:DNA binding:F"], "name": "Gemini_BL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000212": {"description": "UvrD-like helicase", "go_ids": ["GO:0003677", "GO:0003678", "GO:0005524"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003678:DNA helicase activity:F", "GO:0005524:ATP binding:F"], "name": "UvrD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000215": {"description": "Serpin family", "go_ids": ["GO:0004867", "GO:0005576"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F", "GO:0005576:extracellular region:C"], "name": "Serpin_fam", "pathway_ids": ["R-HSA-9926550", "R-DME-140875", "R-BTA-204005", "R-RNO-416476", "R-HSA-75205", "R-RNO-3000178", "R-HSA-381426", "R-SSC-3000178", "R-DME-5694530", "R-MMU-2022377", "R-GGA-1650814", "R-DME-1650814", "R-BTA-194002", "R-DME-114608", "R-MMU-140837", "R-HSA-8950505", "R-HSA-2022377", "R-HSA-9948001", "R-GGA-6798695", "R-BTA-416476", "R-HSA-204005", "R-RNO-381426", "R-DME-9948001", "R-BTA-5694530", "R-DME-8939242", "R-DME-9757110", "R-MMU-6798695", "R-HSA-8939242", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608", "R-MMU-9757110", "R-DME-204005", "R-DME-194002", "R-DME-381426", "R-DME-8957275", "R-HSA-9757110", "R-HSA-9657689", "R-HSA-375276", "R-SSC-114608", "R-DME-2022377", "R-HSA-9925561", "R-HSA-416476", "R-MMU-8939242", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-9757110", "R-HSA-114608", "R-BTA-114608", "R-HSA-5357905", "R-HSA-977606", "R-RNO-8957275", "R-DME-140837", "R-BTA-381426", "R-MMU-194002", "R-RNO-75205", "R-HSA-2173796", "R-BTA-1650814", "R-RNO-1650814", "R-RNO-5694530", "R-MMU-977606", "R-BTA-2022377", "R-DME-6798695", "R-MMU-75205", "R-RNO-2022377", "R-SSC-75205", "R-HSA-140875", "R-RNO-194002", "R-RNO-204005", "R-MMU-140875", "R-HSA-418594", "R-MMU-1650814", "R-RNO-375276", "R-MMU-9948001", "R-BTA-75205", "R-HSA-8957275", "R-DME-209442", "R-HSA-194002", "R-HSA-6798695", "R-MMU-416476", "R-HSA-1989781", "R-MMU-204005", "R-GGA-8939242", "R-HSA-3000178", "R-HSA-140837", "R-MMU-5694530", "R-RNO-140875", "R-BTA-6798695", "R-BTA-9757110", "R-MMU-375276", "R-HSA-9686347", "R-HSA-1368108", "R-HSA-5694530", "R-MMU-8957275", "R-HSA-1650814", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-BTA-418594", "R-BTA-9948001", "R-MMU-3000178", "R-MMU-381426"], "pathways": ["R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-DME-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-DME-5694530:r:Cargo concentration in the ER", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-GGA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-BTA-194002:r:Glucocorticoid biosynthesis", "R-DME-114608:r:Platelet degranulation", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-9948001:r:CASP4 inflammasome assembly", "R-BTA-5694530:r:Cargo concentration in the ER", "R-DME-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-DME-9757110:r:Prednisone ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation", "R-MMU-9757110:r:Prednisone ADME", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DME-194002:r:Glucocorticoid biosynthesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-9757110:r:Prednisone ADME", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-SSC-114608:r:Platelet degranulation", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-9757110:r:Prednisone ADME", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-DME-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-5694530:r:Cargo concentration in the ER", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-SSC-75205:r:Dissolution of Fibrin Clot", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-194002:r:Glucocorticoid biosynthesis", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-9948001:r:CASP4 inflammasome assembly", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-HSA-194002:r:Glucocorticoid biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-GGA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-5694530:r:Cargo concentration in the ER", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-9757110:r:Prednisone ADME", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-5694530:r:Cargo concentration in the ER", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-BTA-418594:r:G alpha (i) signalling events", "R-BTA-9948001:r:CASP4 inflammasome assembly", "R-MMU-3000178:r:ECM proteoglycans", "R-MMU-381426:r:Regulation of 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"R-DME-179812", "R-HSA-9664422", "R-CFA-416482", "R-DME-9013423", "R-CEL-5218920", "R-MMU-418885", "R-DDI-1169092", "R-HSA-9013409", "R-HSA-9607240", "R-MMU-114604", "R-MMU-9013408", "R-RNO-5687128", "R-MMU-9013409", "R-MMU-210993", "R-HSA-442982", "R-DME-9013148", "R-HSA-5218920", "R-MMU-5654706", "R-RNO-6811558", "R-HSA-8853659", "R-MMU-8851805", "R-HSA-389359", "R-DME-74751", "R-MMU-9013420", "R-MMU-5673001", "R-HSA-114604", "R-DME-1433559", "R-GGA-9013420", "R-MMU-167044", "R-DME-9013149", "R-HSA-182971", "R-CFA-8980692", "R-HSA-2424491", "R-HSA-416482", "R-SPO-9013148", "R-HSA-8983432", "R-HSA-5637810", "R-HSA-9696264", "R-MMU-9013423", "R-HSA-5654699", "R-HSA-1433559", "R-DME-1257604", "R-DME-416482", "R-MMU-193648", "R-RNO-9696264", "R-HSA-9013026", "R-HSA-445144", "R-MMU-2730905", "R-MMU-5687128", "R-CEL-8849932", "R-HSA-1839117", "R-BTA-2029482", "R-HSA-5655253", "R-HSA-416572", "R-DME-5673001", "R-RNO-9035034", "R-MMU-8980692", "R-MMU-5654699", "R-HSA-9013106", "R-HSA-9665348", "R-HSA-2428933", "R-BTA-9013148", "R-RNO-9027284", "R-DME-1433557", "R-BTA-9013423", "R-HSA-9013423", "R-MMU-1250347", "R-MMU-512988", "R-HSA-1250196", "R-HSA-2730905", "R-CFA-416572", "R-GGA-193648", "R-HSA-5654719", "R-MMU-112412", "R-HSA-9032845", "R-DME-5654699", "R-MMU-9027284", "R-BTA-1433557", "R-BTA-512988", "R-CEL-193648", "R-CEL-9013423", "R-MMU-3928664", "R-HSA-1963640", "R-HSA-5655291", "R-MMU-912631", "R-DRE-9013409", "R-HSA-5654712", "R-MMU-9028731", "R-DME-112412", "R-DME-167044", "R-DDI-392517", "R-MMU-8983432", "R-CEL-3928665", "R-HSA-9634285", "R-BTA-9013404", "R-HSA-912526", "R-BTA-1257604", "R-MMU-5654693", "R-HSA-446388", "R-BTA-9027284", "R-MMU-9013149", "R-DME-5654706", "R-MMU-74749", "R-HSA-5654688", "R-HSA-1989781", "R-DDI-354192", "R-MMU-182971", "R-MMU-389359", "R-MMU-9607240", "R-DME-375165", "R-CEL-354194", "R-DME-114604", "R-CEL-912631", "R-RNO-9013149", "R-HSA-2179392", "R-MMU-9013404", "R-HSA-9013424", "R-CEL-416482", "R-MMU-446388", "R-HSA-3928662", "R-HSA-4420097", "R-MMU-2871796", "R-DME-2424491", "R-RNO-9013424", "R-BTA-2871809", "R-CEL-1433559", "R-RNO-9013406", "R-HSA-9664565", "R-HSA-5655302", "R-CEL-9013148", "R-CEL-5654693", "R-DDI-193648", "R-MMU-9748787", "R-HSA-9665686", "R-DME-8980692", "R-MMU-8853659", "R-HSA-2219530", "R-MMU-445144", "R-DME-5654688", "R-BTA-912631", "R-MMU-5654700", "R-RNO-8964616", "R-RNO-9696273", "R-RNO-418885", "R-HSA-9013404", "R-SCE-9013148", "R-HSA-9013149", "R-HSA-8980692", "R-DME-445144", "R-CFA-9013106", "R-HSA-9703648", "R-DME-1963640", "R-BTA-114604", "R-HSA-8948751", "R-MMU-5654688", "R-DRE-416482", "R-HSA-5654704", "R-BTA-9013106", "R-RNO-4420097", "R-MMU-375165", "R-RNO-977443", "R-CEL-375165", "R-MMU-8856825", "R-HSA-977443", "R-HSA-416476", "R-HSA-418885", "R-DDI-9013149", "R-CEL-9013149", "R-DME-6811558", "R-DDI-381676", "R-DME-2871809", "R-HSA-1236382", "R-BTA-2871796", "R-HSA-9619229", "R-RNO-9013106", "R-MMU-5654719", "R-HSA-9028731", "R-HSA-193648", "R-HSA-9013420", "R-DRE-9013408", "R-DDI-171007", "R-HSA-8964616", "R-HSA-354194", "R-MMU-3928663", "R-HSA-9679191", "R-MMU-983695", "R-HSA-1433557", "R-CEL-180336", "R-RNO-114604", "R-HSA-9703465", "R-BTA-9013408", "R-GGA-8964616", "R-HSA-5687128", "R-MMU-2871809", "R-MMU-9013026", "R-MMU-2424491", "R-DRE-416476", "R-DME-4420097", "R-CFA-193648", "R-HSA-9696273", "R-CEL-5654704"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-GGA-416482:r:G alpha (12/13) signalling events", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-9607240:r:FLT3 Signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9607240:r:FLT3 Signaling", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-SCE-193648:r:NRAGE signals death through JNK", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-8851805:r:MET activates RAS signaling", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DRE-8980692:r:RHOA GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-977443:r:GABA receptor activation", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-CEL-9748787:r:Azathioprine ADME", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-HSA-74749:r:Signal attenuation", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-3928664:r:Ephrin signaling", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DME-74749:r:Signal attenuation", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-428540:r:Activation of RAC1", "R-DME-186763:r:Downstream signal transduction", "R-DRE-193648:r:NRAGE signals death through JNK", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-210993:r:Tie2 Signaling", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-912631:r:Regulation of signaling by CBL", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-DME-210993:r:Tie2 Signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-9748787:r:Azathioprine ADME", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-3928664:r:Ephrin signaling", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-DME-8853659:r:RET signaling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-186763:r:Downstream signal transduction", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9842663:r:Signaling by LTK", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-9748787:r:Azathioprine ADME", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8851805:r:MET activates RAS signaling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-445144:r:Signal transduction by L1", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-186763:r:Downstream signal transduction", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-182971:r:EGFR downregulation", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-DME-9013423:r:RAC3 GTPase cycle", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-418885:r:DCC mediated attractive signaling", "R-DDI-1169092:r:Activation of RAS in B cells", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9607240:r:FLT3 Signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-DME-74751:r:Insulin receptor signalling cascade", "R-MMU-9013420:r:RHOU GTPase cycle", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-GGA-9013420:r:RHOU GTPase cycle", "R-MMU-167044:r:Signalling to RAS", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-CFA-8980692:r:RHOA GTPase cycle", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-HSA-8983432:r:Interleukin-15 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1433559:r:Regulation of KIT signaling", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-DME-1433557:r:Signaling by SCF-KIT", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-GGA-193648:r:NRAGE signals death through JNK", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-112412:r:SOS-mediated signalling", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-193648:r:NRAGE signals death through JNK", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-912631:r:Regulation of signaling by CBL", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DME-112412:r:SOS-mediated signalling", "R-DME-167044:r:Signalling to RAS", "R-DDI-392517:r:Rap1 signalling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-74749:r:Signal attenuation", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-354192:r:Integrin signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-114604:r:GPVI-mediated activation cascade", "R-CEL-912631:r:Regulation of signaling by CBL", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DME-2424491:r:DAP12 signaling", "R-RNO-9013424:r:RHOV GTPase cycle", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-1433559:r:Regulation of KIT signaling", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-9748787:r:Azathioprine ADME", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-8853659:r:RET signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-BTA-912631:r:Regulation of signaling by CBL", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-CFA-9013106:r:RHOC GTPase cycle", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-RNO-977443:r:GABA receptor activation", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-977443:r:GABA receptor activation", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DRE-9013408:r:RHOG GTPase cycle", "R-DDI-171007:r:p38MAPK events", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-9013408:r:RHOG GTPase cycle", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-2424491:r:DAP12 signaling", "R-DRE-416476:r:G alpha (q) signalling events", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-CFA-193648:r:NRAGE signals death through JNK", "R-HSA-9696273:r:RND1 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3"], "type": "Domain"}, "IPR000221": {"description": "Protamine P1", "go_ids": ["GO:0000786", "GO:0003677", "GO:0005634", "GO:0007283", "GO:0035092"], "go_terms": ["GO:0000786:nucleosome:C", "GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0007283:spermatogenesis:P", "GO:0035092:sperm DNA condensation:P"], "name": "Protamine_P1", "pathway_ids": ["R-HSA-9821993"], "pathways": ["R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus"], "type": "Family"}, "IPR000223": {"description": "Peptidase S26A, signal peptidase I", "go_ids": ["GO:0006508", "GO:0008236", "GO:0016020"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008236:serine-type peptidase activity:F", "GO:0016020:membrane:C"], "name": "Pept_S26A_signal_pept_1", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR000225": {"description": "Armadillo", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Armadillo", "pathway_ids": ["R-HSA-9615933", "R-HSA-1445148", "R-HSA-9013026", "R-HSA-9793380", "R-DDI-983712", "R-HSA-9768727", "R-MMU-9768727", "R-RNO-6798695", "R-SSC-9762292", "R-HSA-9705671", "R-BTA-195253", "R-MMU-8980692", "R-SCE-6798695", "R-RNO-351906", "R-MMU-983189", "R-BTA-9013406", "R-HSA-9013106", "R-HSA-9861718", "R-BTA-6807878", "R-DME-209396", 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"R-HSA-9824585", "R-DME-201722", "R-HSA-8876493", "R-HSA-177504", "R-BTA-8856825", "R-DRE-9013148", "R-MMU-140342", "R-RNO-4086398", "R-BTA-8964038", "R-DME-209440", "R-HSA-983189", "R-HSA-9692916", "R-RNO-9766229", "R-CEL-8951430", "R-HSA-9013406", "R-HSA-9013419", "R-CEL-5218920", "R-HSA-9013409", "R-HSA-180910", "R-BTA-68616", "R-MMU-9861718", "R-MMU-4086398", "R-HSA-9918485", "R-CEL-195253", "R-MMU-5689896", "R-SCE-2995383", "R-RNO-525793", "R-RNO-111465", "R-BTA-525793", "R-SSC-9764561", "R-RNO-9825892", "R-HSA-6811434", "R-HSA-5218920", "R-BTA-5626467", "R-HSA-5140745", "R-MMU-1655829", "R-HSA-5358752", "R-MMU-196299", "R-HSA-5620924", "R-DRE-9764561", "R-DME-209461", "R-RNO-9013407", "R-DME-6809371", "R-BTA-177504", "R-HSA-164940", "R-HSA-9696264"], "pathways": ["R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9793380:r:Formation of paraxial 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nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR000229": {"description": "Nucleocapsid protein, arenaviridae", "go_ids": ["GO:0019013"], "go_terms": ["GO:0019013:viral nucleocapsid:C"], "name": "Nucleocapsid_arenaviridae", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000232": {"description": "Heat shock factor (HSF)-type, DNA-binding", "go_ids": ["GO:0003700", "GO:0006355", "GO:0043565"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0043565:sequence-specific DNA binding:F"], "name": "HSF_DNA-bd", "pathway_ids": ["R-SCE-3371453", "R-HSA-3371511", "R-HSA-9646399", "R-SPO-3371453", "R-DME-3371453", "R-SPO-3371568", "R-BTA-3371453", "R-BTA-3371568", "R-CEL-9841251", "R-SPO-3371571", "R-BTA-3371511", "R-HSA-9841251", "R-CEL-3371571", "R-CEL-3371511", "R-SCE-9841251", "R-MMU-3371571", "R-BTA-3371571", "R-SCE-3371568", "R-DME-3371511", "R-CEL-3371568", "R-SPO-3371511", "R-DME-3371568", "R-HSA-3371453", "R-DME-3371571", "R-MMU-3371568", "R-MMU-9841251", "R-DME-9841251", "R-SPO-9841251", "R-MMU-3371511", "R-HSA-3371571", "R-BTA-9841251", "R-SCE-3371511", "R-HSA-3371568", "R-SCE-3371571", "R-CEL-3371453", "R-MMU-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371511:r:HSF1 activation", "R-HSA-9646399:r:Aggrephagy", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371568:r:Attenuation phase", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371568:r:Attenuation phase", "R-CEL-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-BTA-3371511:r:HSF1 activation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-CEL-3371511:r:HSF1 activation", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-SCE-3371568:r:Attenuation phase", "R-DME-3371511:r:HSF1 activation", "R-CEL-3371568:r:Attenuation phase", "R-SPO-3371511:r:HSF1 activation", "R-DME-3371568:r:Attenuation phase", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371571:r:HSF1-dependent transactivation", "R-MMU-3371568:r:Attenuation phase", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-3371511:r:HSF1 activation", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SCE-3371511:r:HSF1 activation", "R-HSA-3371568:r:Attenuation phase", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR000233": {"description": "Cadherin, Y-type LIR-motif", "go_ids": ["GO:0005509", "GO:0007156"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0007156:homophilic cell-cell adhesion:P"], "name": "Cadherin_Y-type_LIR", "pathway_ids": ["R-HSA-6798695", "R-DRE-9768727", "R-RNO-1474228", "R-HSA-9766229", "R-HSA-351906", "R-HSA-9927418", "R-MMU-8957275", "R-RNO-525793", "R-HSA-9764562", "R-HSA-418990", "R-HSA-9764561", "R-DRE-5626467", "R-HSA-5218920", "R-DRE-6798695", "R-HSA-9823730", "R-MMU-381426", "R-GGA-8957275", "R-HSA-9926550", "R-CFA-418990", "R-HSA-9759811", "R-DRE-418990", "R-RNO-6805567", "R-RNO-9768727", "R-DRE-9696270", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-BTA-418990", "R-SSC-418990", "R-DRE-5218920", "R-CFA-351906", "R-DRE-6805567", "R-DRE-9764561", "R-SSC-351906", "R-CFA-6805567", "R-MMU-351906", "R-GGA-525793", "R-DME-6809371", "R-MMU-9762292", "R-HSA-9696264", "R-RNO-381426", "R-DRE-9766229", "R-MMU-6809371", "R-CFA-1474228", "R-DRE-381426", "R-MMU-216083", "R-HSA-9762292", "R-DRE-351906", "R-HSA-198933", "R-MMU-6798695", "R-MMU-9696264", "R-HSA-9768727", "R-MMU-9768727", "R-MMU-9766229", "R-DRE-525793", "R-SSC-9696270", "R-SSC-6798695", "R-SSC-9696264", "R-HSA-6809371", "R-RNO-216083", "R-HSA-5626467", "R-DRE-1474228", "R-RNO-418990", "R-RNO-351906", "R-CFA-216083", "R-CFA-9768727", "R-DRE-9696264", "R-MMU-9764561", "R-RNO-8957275", "R-SSC-5218920", "R-HSA-9938206", "R-GGA-381426", "R-HSA-525793", "R-HSA-6805567", "R-CFA-6809371", "R-DRE-8957275", "R-CFA-9766229", "R-RNO-6809371", "R-RNO-9764561", "R-MMU-5626467", "R-HSA-216083", "R-HSA-9696270", "R-GGA-418990", "R-DME-6798695", "R-MMU-5218920", "R-HSA-9927432", "R-DRE-6809371", "R-RNO-5626467", "R-CFA-9764561", "R-HSA-9764302", "R-DME-351906", "R-MMU-418990", "R-HSA-8876493", "R-SSC-6805567", "R-SSC-6809371", "R-RNO-9766229", "R-HSA-9856649", "R-MMU-525793", "R-HSA-8957275", "R-HSA-9856530", "R-HSA-9833576", "R-MMU-9696270", "R-MMU-6805567", "R-DME-9013423"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9766229:r:Degradation of CDH1", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-525793:r:Myogenesis", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-418990:r:Adherens junctions interactions", 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"R-DRE-9766229:r:Degradation of CDH1", "R-MMU-6809371:r:Formation of the cornified envelope", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9762292:r:Regulation of CDH11 function", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9766229:r:Degradation of CDH1", "R-DRE-525793:r:Myogenesis", "R-SSC-9696270:r:RND2 GTPase cycle", "R-SSC-6798695:r:Neutrophil degranulation", "R-SSC-9696264:r:RND3 GTPase cycle", "R-HSA-6809371:r:Formation of the cornified envelope", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-RNO-418990:r:Adherens junctions interactions", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-CFA-216083:r:Integrin cell surface interactions", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-DRE-9696264:r:RND3 GTPase cycle", "R-MMU-9764561:r:Regulation of CDH1 Function", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-525793:r:Myogenesis", "R-HSA-6805567:r:Keratinization", 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monocytogenes into host cells", "R-SSC-6805567:r:Keratinization", "R-SSC-6809371:r:Formation of the cornified envelope", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-525793:r:Myogenesis", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9833576:r:CDH11 homotypic and heterotypic interactions", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-6805567:r:Keratinization", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR000235": {"description": "Small ribosomal subunit protein uS7", "go_ids": ["GO:0006412"], "go_terms": ["GO:0006412:translation:P"], "name": "Ribosomal_uS7", "pathway_ids": ["R-GGA-5389840", "R-HSA-5419276", "R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-DME-6791226", "R-SPO-975957", "R-RNO-1799339", "R-DME-9937383", "R-DME-9954716", "R-RNO-72695", "R-HSA-72695", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-BTA-72689", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-RNO-5419276", "R-HSA-5368286", "R-CEL-72706", "R-BTA-72695", "R-RNO-9937383", "R-HSA-5389840", "R-CEL-9954716", "R-CEL-9954714", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-DDI-72695", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-BTA-9937383", "R-CEL-156827", "R-RNO-72649", "R-RNO-6791226", "R-CEL-9937383", "R-HSA-6791226", "R-RNO-975956", "R-CEL-72649", "R-SPO-156827", "R-DME-5389840", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-MMU-5389840", "R-SPO-72689", "R-CEL-72689", "R-MMU-1799339", "R-DDI-72702", "R-DDI-72689", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", 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"R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-GGA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72695:r:Formation of 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"R-MMU-983695", "R-RNO-180292", "R-HSA-1433557", "R-GGA-432142"], "pathways": ["R-MMU-877300:r:Interferon gamma signaling", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-8873719:r:RAB geranylgeranylation", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-GGA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-389948:r:Co-inhibition by PD-1", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9607240:r:FLT3 Signaling", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-77387:r:Insulin receptor recycling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-3000178:r:ECM proteoglycans", "R-GGA-8865999:r:MET activates PTPN11", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-210993:r:Tie2 Signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-GGA-5654695:r:PI-3K cascade:FGFR2", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-877312:r:Regulation of IFNG signaling", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-GGA-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-201556:r:Signaling by ALK", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-8853659:r:RET signaling", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-210693:r:STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-182971:r:EGFR downregulation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-GGA-5654689:r:PI-3K cascade:FGFR1", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-GGA-1059683:r:Interleukin-6 signaling", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-GGA-389948:r:Co-inhibition by PD-1", "R-GGA-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-416700:r:Other semaphorin interactions", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-BTA-77387:r:Insulin receptor recycling", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-354192:r:Integrin signaling", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-8865999:r:MET activates PTPN11", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-RNO-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-354192:r:Integrin signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-109704:r:PI3K Cascade", "R-GGA-210993:r:Tie2 Signaling", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-416700:r:Other semaphorin interactions", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-109704:r:PI3K Cascade", "R-MMU-9706369:r:Negative regulation of FLT3", "R-GGA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8873719:r:RAB geranylgeranylation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-GGA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-9833482:r:PKR-mediated signaling", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-201556:r:Signaling by ALK", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-MMU-9696273:r:RND1 GTPase cycle", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-182971:r:EGFR downregulation", "R-MMU-1433559:r:Regulation of KIT signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-6798695:r:Neutrophil degranulation", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-HSA-432142:r:Platelet sensitization by LDL", "R-GGA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-9927353:r:Co-inhibition by BTLA", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-RNO-8849472:r:PTK6 Down-Regulation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-GGA-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-RNO-8865999:r:MET activates PTPN11", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-GGA-109704:r:PI3K Cascade", "R-GGA-8854691:r:Interleukin-20 family signaling", "R-GGA-5654720:r:PI-3K cascade:FGFR4", "R-GGA-180292:r:GAB1 signalosome", "R-RNO-201556:r:Signaling by ALK", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-RNO-8853659:r:RET signaling", "R-HSA-210993:r:Tie2 Signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-GGA-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-RNO-77387:r:Insulin receptor recycling", "R-GGA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-MMU-416700:r:Other semaphorin interactions", "R-GGA-5654710:r:PI-3K cascade:FGFR3", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-RNO-432142:r:Platelet sensitization by LDL", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-449836:r:Other interleukin signaling", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-8873719:r:RAB geranylgeranylation", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-RNO-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-449836:r:Other interleukin signaling", "R-RNO-109704:r:PI3K Cascade", "R-CEL-416700:r:Other semaphorin interactions", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-GGA-186763:r:Downstream signal transduction", "R-HSA-210990:r:PECAM1 interactions", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-354192:r:Integrin signaling", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9645135:r:STAT5 Activation", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-GGA-210990:r:PECAM1 interactions", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-DME-77387:r:Insulin receptor recycling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-DME-877312:r:Regulation of IFNG signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-GGA-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR000243": {"description": "Peptidase T1A, proteasome beta-subunit", "go_ids": ["GO:0005839", "GO:0030163", "GO:0004298"], "go_terms": ["GO:0005839:proteasome core complex:C", "GO:0030163:protein catabolic process:P", "GO:0004298:threonine-type endopeptidase activity:F"], "name": "Pept_T1A_subB", 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"R-RNO-5607761", "R-HSA-68867", "R-MMU-9907900", "R-CEL-4641258", "R-BTA-450408", "R-DDI-5658442", "R-HSA-8941858", "R-HSA-9755511", "R-RNO-9931269", "R-SSC-69601", "R-CEL-9929491", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-HSA-5689603", "R-RNO-983168", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DDI-9755511", "R-HSA-349425", "R-BTA-8941858", "R-SSC-174178", "R-SSC-8951664", "R-HSA-174184", "R-SPO-1236974", "R-MMU-350562", "R-MMU-69601", "R-SSC-174084", "R-CEL-1236974", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-SSC-1236978", "R-SSC-5689880", "R-MMU-8854050", "R-MMU-5689603", "R-SSC-5658442", "R-MMU-9912633", "R-HSA-5607764", "R-RNO-1236978", "R-SSC-5668541", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-SSC-9954709", "R-SSC-8852276", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-69601", "R-CEL-68949", "R-HSA-5687128", "R-RNO-5658442", "R-MMU-1236974", "R-MMU-983168", "R-RNO-5610785", "R-SSC-4608870", "R-HSA-350562", "R-DDI-174178"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-SSC-5689603:r:UCH proteinases", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-SSC-8948751:r:Regulation of PTEN stability and activity", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SPO-5689880:r:Ub-specific processing proteases", "R-CFA-9907900:r:Proteasome assembly", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-SSC-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-SPO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-SSC-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-SSC-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5632684:r:Hedgehog 'on' state", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SSC-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9907900:r:Proteasome assembly", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-1236974:r:ER-Phagosome pathway", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SSC-5358346:r:Hedgehog ligand biogenesis", "R-DDI-5689880:r:Ub-specific processing proteases", "R-SSC-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-1236974:r:ER-Phagosome pathway", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SSC-4641257:r:Degradation of AXIN", "R-SSC-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-SSC-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-4641258:r:Degradation of DVL", "R-SPO-5689603:r:UCH proteinases", "R-SSC-68949:r:Orc1 removal from chromatin", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-4641258:r:Degradation of DVL", 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"IPR000249": {"description": "Bacterial microcompartment domain", "go_ids": ["GO:0031469"], "go_terms": ["GO:0031469:bacterial microcompartment:C"], "name": "BMC_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000250": {"description": "Peptidase G1", "go_ids": ["GO:0006508"], "go_terms": ["GO:0006508:proteolysis:P"], "name": "Peptidase_G1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000253": {"description": "Forkhead-associated (FHA) domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "FHA_dom", "pathway_ids": ["R-HSA-6802952", "R-MMU-9770562", "R-RNO-5693565", "R-DDI-6804760", "R-GGA-351433", "R-RNO-5685939", "R-RNO-72163", "R-MMU-6804756", "R-HSA-5693565", "R-CEL-6804760", "R-MMU-75035", "R-MMU-5685938", "R-MMU-69473", "R-HSA-418990", "R-DRE-5693571", "R-HSA-6811434", "R-DDI-5673000", "R-MMU-5696394", "R-DRE-5693579", "R-MMU-6811434", "R-MMU-6804760", "R-GGA-217106", "R-HSA-69473", "R-MMU-72163", "R-MMU-5625900", "R-SCE-69473", "R-BTA-5693565", "R-HSA-6804760", "R-RNO-5693571", "R-DME-6804756", "R-DRE-5693548", "R-HSA-72163", "R-HSA-6804756", "R-DDI-5674135", "R-RNO-5693568", "R-HSA-5696394", "R-DME-69601", "R-DRE-5693616", "R-MMU-3108214", "R-DRE-5693607", "R-HSA-5625900", "R-HSA-5685942", "R-HSA-9772755", "R-SCE-69601", "R-MMU-9645460", "R-MMU-983189", "R-DME-5693565", "R-SPO-69473", "R-DRE-5685939", "R-RNO-5693548", "R-MMU-5693565", "R-HSA-75035", "R-RNO-9645460", "R-RNO-5685938", "R-DDI-69601", "R-BTA-445989", "R-HSA-912446", "R-MMU-5685939", "R-MMU-9772755", "R-GGA-351442", "R-MMU-5693579", "R-SCE-3232118", "R-HSA-5693568", "R-MMU-5693607", "R-HSA-9701192", "R-MMU-3214847", "R-CEL-69473", "R-HSA-9770562", "R-HSA-9696270", "R-MMU-6804757", "R-HSA-9709603", "R-XTR-9645460", "R-SPO-5693565", "R-HSA-5685939", "R-DDI-5675221", "R-CEL-5693565", "R-RNO-5685942", "R-BTA-9645460", "R-SCE-9018519", "R-HSA-5693571", "R-BTA-5693571", "R-HSA-3214847", "R-DME-75035", "R-MMU-9696273", "R-HSA-5693579", "R-SCE-75035", "R-HSA-5693616", "R-RNO-983189", "R-MMU-5693616", "R-HSA-6796648", "R-MMU-69541", "R-DDI-5693565", "R-DRE-5693568", "R-HSA-9709570", "R-HSA-5693607", "R-MMU-445989", "R-HSA-6804757", "R-BTA-5693607", "R-MMU-5693568", "R-SPO-5685939", "R-DRE-6804756", "R-RNO-5693579", "R-MMU-2559586", "R-DME-69473", "R-RNO-5693607", "R-DRE-5685942", "R-RNO-69473", "R-HSA-9704331", "R-DRE-69473", "R-RNO-445989", "R-SPO-75035", "R-DRE-5693565", "R-HSA-5689603", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-HSA-2559586", "R-MMU-5693571", "R-HSA-445989", "R-BTA-69473", "R-HSA-3108214", "R-HSA-9704646", "R-DDI-69473", "R-RNO-418990", "R-CEL-75035", "R-MMU-69601", "R-SCE-5693565", "R-DDI-75035", "R-DRE-2559586", "R-GGA-351444", "R-RNO-6804756", "R-MMU-5689603", "R-HSA-5685938", "R-RNO-2559586", "R-RNO-6811434", "R-HSA-390471", "R-MMU-5693548", "R-HSA-69601", "R-MMU-5685942", "R-HSA-9645460", "R-MMU-418990", "R-CEL-69601", "R-SPO-2559586", "R-HSA-983189", "R-HSA-69541", "R-SPO-5693548", "R-SPO-69601", "R-MMU-9696270", "R-DME-69541", "R-HSA-9696273", "R-DRE-5685938"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-6804760:r:Regulation of TP53 Activity through Methylation", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-418990:r:Adherens junctions interactions", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-5673000:r:RAF activation", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-SCE-69473:r:G2/M DNA damage checkpoint", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-SCE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-983189:r:Kinesins", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SPO-69473:r:G2/M DNA damage checkpoint", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-3214847:r:HATs acetylate histones", "R-CEL-69473:r:G2/M DNA damage checkpoint", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-XTR-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SCE-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-983189:r:Kinesins", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-69541:r:Stabilization of p53", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SPO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-DDI-69473:r:G2/M DNA damage checkpoint", "R-RNO-418990:r:Adherens junctions interactions", "R-CEL-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-418990:r:Adherens junctions interactions", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-983189:r:Kinesins", "R-HSA-69541:r:Stabilization of p53", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-SPO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DME-69541:r:Stabilization of p53", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR000254": {"description": "Cellulose-binding domain", "go_ids": ["GO:0005576", "GO:0005975", "GO:0030248"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0005975:carbohydrate metabolic process:P", "GO:0030248:cellulose binding:F"], "name": "CBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000256": {"description": "Influenza A virus NS1 protein", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "NS1A", "pathway_ids": ["R-HSA-5213460", "R-HSA-168888", "R-HSA-168276", "R-HSA-9833482", "R-HSA-168315", "R-HSA-1169408", "R-HSA-9686347", "R-HSA-169131", "R-HSA-9953170", "R-HSA-192823"], "pathways": ["R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-168888:r:Inhibition of IFN-beta", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-168315:r:Inhibition of Host mRNA Processing and RNA Silencing", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-169131:r:Inhibition of PKR", "R-HSA-9953170:r:GBP-mediated host defense", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Family"}, "IPR000257": {"description": "Uroporphyrinogen decarboxylase (URO-D)", "go_ids": ["GO:0004853", "GO:0006779"], "go_terms": ["GO:0004853:uroporphyrinogen decarboxylase activity:F", "GO:0006779:porphyrin-containing compound biosynthetic process:P"], "name": "Uroporphyrinogen_deCOase", "pathway_ids": ["PWY-7159", "PWY-5531", "PWY-7766", "R-DDI-189451", "R-RNO-189451", "R-DRE-189451", "R-DME-189451", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)", "PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7766:t:heme b biosynthesis IV (Gram-positive bacteria)", "R-DDI-189451:r:Heme biosynthesis", "R-RNO-189451:r:Heme biosynthesis", "R-DRE-189451:r:Heme biosynthesis", "R-DME-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Domain"}, "IPR000258": {"description": "Bacterial ice-nucleation, octamer repeat", "go_ids": ["GO:0009279"], "go_terms": ["GO:0009279:cell outer membrane:C"], "name": "Ice_nucleatn", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR000259": {"description": "Fimbrial-type adhesion domain", "go_ids": ["GO:0007155", "GO:0009289"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0009289:pilus:C"], "name": "Adhesion_dom_fimbrial", "pathway_ids": ["R-HSA-9638630"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells"], "type": "Domain"}, "IPR000260": {"description": "NADH:ubiquinone oxidoreductase chain 4, N-terminal", "go_ids": [], "go_terms": [], "name": "NADH4_N", "pathway_ids": ["PWY-4302", "PWY-6692", "PWY-3781", "PWY-5083", "R-HSA-5419276", "R-SSC-5419276", "R-HSA-6799198", "R-MMU-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DRE-611105", "R-SSC-6799198", "R-GGA-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-GGA-5419276", "R-RNO-5419276", "R-GGA-611105", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-DRE-5419276", "R-BTA-6799198", "R-SSC-611105", "R-BTA-611105"], "pathways": ["PWY-4302:t:aerobic respiration III (alternative oxidase pathway)", "PWY-6692:t:Fe(II) oxidation", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-5083:t:NAD(P)/NADPH interconversion", "R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-SSC-6799198:r:Complex I biogenesis", "R-GGA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-611105:r:Respiratory electron transport", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DRE-5419276:r:Mitochondrial translation termination", "R-BTA-6799198:r:Complex I biogenesis", "R-SSC-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR000261": {"description": "EH domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "EH_dom", "pathway_ids": ["R-MMU-8856828", "R-SPO-416482", "R-MMU-182971", "R-MMU-8856825", "R-HSA-8856828", "R-SCE-416482", "R-HSA-9766229", "R-MMU-9013408", "R-MMU-9013148", "R-MMU-983231", "R-HSA-3928662", "R-BTA-983231", "R-SPO-9013406", "R-DDI-8856825", "R-MMU-9013420", "R-SCE-9013406", "R-RNO-416482", "R-RNO-983231", "R-HSA-9013148", "R-RNO-3928662", "R-DDI-8856828", "R-SCE-9013420", "R-SPO-9013420", "R-RNO-9013408", "R-HSA-9013408", "R-RNO-9013406", "R-RNO-8856828", "R-RNO-193648", "R-HSA-193648", "R-HSA-9013420", "R-HSA-182971", "R-RNO-8856825", "R-HSA-983231", "R-HSA-416482", "R-RNO-9013148", "R-HSA-6807004", "R-SPO-9013148", "R-SCE-193648", "R-SCE-9013148", "R-HSA-8856825", "R-MMU-9013406", "R-MMU-416482", "R-MMU-3928662", "R-MMU-193648", "R-MMU-6807004", "R-HSA-9013406", "R-MMU-9766229", "R-HSA-8875360"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-MMU-182971:r:EGFR downregulation", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013420:r:RHOU GTPase cycle", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-SCE-9013420:r:RHOU GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-6807004:r:Negative regulation of MET activity", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-SCE-193648:r:NRAGE signals death through JNK", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell"], "type": "Domain"}, "IPR000262": {"description": "FMN-dependent dehydrogenase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "FMN-dep_DH", "pathway_ids": ["R-BTA-9033241", "R-MMU-390918", "R-RNO-9033241", "R-HSA-390918", "R-SPO-9033241", "R-BTA-390918", "R-RNO-390918", "R-MMU-389661", "R-HSA-389661", "R-DDI-389661", "R-RNO-389661", "R-MMU-9033241", "R-DDI-9033241", "R-HSA-9033241", "R-SPO-390918"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-MMU-390918:r:Peroxisomal lipid metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-SPO-9033241:r:Peroxisomal protein import", "R-BTA-390918:r:Peroxisomal lipid metabolism", "R-RNO-390918:r:Peroxisomal lipid metabolism", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-DDI-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-389661:r:Glyoxylate metabolism and glycine degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-SPO-390918:r:Peroxisomal lipid metabolism"], "type": "Domain"}, "IPR000263": {"description": "Geminivirus AR1/BR1 coat protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "GV_A/BR1_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000264": {"description": "ALB/AFP/VDB", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "ALB/AFP/VDB", "pathway_ids": ["R-RNO-189451", "R-HSA-9757110", "R-HSA-2168880", "R-MMU-8957275", "R-HSA-189483", "R-RNO-114608", "R-RNO-9757110", "R-BTA-8957275", "R-HSA-114608", "R-HSA-196791", "R-RNO-9793528", "R-MMU-189483", "R-RNO-159418", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-9707564", "R-MMU-9749641", "R-RNO-189483", "R-RNO-8964058", "R-MMU-8964058", "R-HSA-381426", "R-MMU-2168880", "R-SSC-381426", "R-SSC-8957275", "R-MMU-189451", "R-HSA-8964058", "R-MMU-9757110", "R-RNO-2168880", "R-RNO-9707564", "R-MMU-9793528", "R-HSA-189451", "R-RNO-381426", "R-RNO-196791", "R-MMU-196791", "R-HSA-9749641", "R-HSA-9793528", "R-RNO-9749641", "R-HSA-8957275", "R-HSA-159418", "R-MMU-159418", "R-MMU-9707564", "R-MMU-114608"], "pathways": ["R-RNO-189451:r:Heme biosynthesis", "R-HSA-9757110:r:Prednisone ADME", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-189483:r:Heme degradation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-9757110:r:Prednisone ADME", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-MMU-189483:r:Heme degradation", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-189483:r:Heme degradation", "R-RNO-8964058:r:HDL remodeling", "R-MMU-8964058:r:HDL remodeling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-189451:r:Heme biosynthesis", "R-HSA-8964058:r:HDL remodeling", "R-MMU-9757110:r:Prednisone ADME", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-HSA-189451:r:Heme biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-RNO-9749641:r:Aspirin ADME", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-159418:r:Recycling of bile acids and salts", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR000266": {"description": "Small ribosomal subunit protein uS17", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uS17", "pathway_ids": ["R-SCE-6791226", "R-DDI-9954714", "R-HSA-5368286", "R-BTA-72695", "R-HSA-5389840", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-DDI-72695", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-BTA-9937383", "R-RNO-6791226", "R-RNO-72649", "R-HSA-6791226", "R-RNO-975956", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-MMU-5389840", "R-SPO-72689", "R-DDI-72702", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", "R-MMU-9937383", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-DME-72649", "R-HSA-156827", "R-RNO-72689", 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"R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent 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"R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin 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"R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-DME-9664873:r:Pexophagy", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-420029:r:Tight junction interactions", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", 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"R-RNO-428930", "R-BTA-8856825", "R-DME-400042", "R-SSC-8856828", "R-DRE-5620916", "R-BTA-380108", "R-RNO-375276", "R-BTA-419771", "R-SSC-2514859", "R-MMU-416482", "R-BTA-428930", "R-CEL-390651", "R-CFA-390696", "R-HSA-9036092", "R-DME-390666", "R-RNO-390696", "R-RNO-202040", "R-HSA-5689880", "R-CFA-8856825", "R-MMU-881907", "R-RNO-140875", "R-BTA-2514859", "R-CFA-375281", "R-MMU-9706019", "R-MMU-9009391", "R-BTA-400042", "R-MMU-419408", "R-HSA-9918450", "R-MMU-392023", "R-MMU-456926", "R-DME-390696", "R-SSC-390648", "R-DME-390650", "R-HSA-2187335", "R-MMU-390650", "R-SSC-389397", "R-RNO-444209", "R-RNO-390648", "R-DME-390651", "R-MMU-417973", "R-SSC-2453902", "R-HSA-173107", "R-MMU-373076", "R-HSA-434316", "R-RNO-111885", "R-HSA-392851", "R-HSA-390651", "R-HSA-418592", "R-GGA-373076", "R-RNO-419771", "R-HSA-9660826", "R-HSA-416482", "R-HSA-400042", "R-HSA-9609690", "R-HSA-388479", "R-RNO-5689880", "R-MMU-432040", "R-BTA-417973", "R-CFA-375276", "R-MMU-376176", "R-GGA-418555", "R-BTA-432040", "R-MMU-400511", "R-RNO-881907", "R-RNO-373076", "R-CEL-418597", "R-CFA-416476", "R-HSA-418597", "R-CEL-8856825", "R-RNO-6798695", "R-HSA-5620922", "R-DME-418555", "R-HSA-375280", "R-HSA-375276", "R-HSA-392023", "R-RNO-5620922", "R-DRE-373076", "R-MMU-418597", "R-BTA-390696", "R-HSA-390696", "R-HSA-417957", "R-HSA-5620916", "R-DME-419771", "R-RNO-417957", "R-RNO-419408", "R-BTA-8856828", "R-BTA-5632684", "R-GGA-390648", "R-MMU-977606", "R-CFA-8856828", "R-SSC-5620916", "R-RNO-388479", "R-HSA-376176", "R-BTA-419408", "R-BTA-380095", "R-DME-418594", "R-DRE-375280", "R-MMU-389397", "R-RNO-2453902", "R-CEL-391906", "R-MMU-140875", "R-RNO-9856530", "R-CFA-2187335", "R-HSA-187024", "R-CFA-390650", "R-HSA-877300", "R-CFA-444821", "R-SSC-390696", "R-GGA-417957", "R-BTA-5683826", "R-CFA-381753", "R-HSA-9856530", "R-RNO-380095", "R-MMU-417957", "R-RNO-418597", "R-DRE-5632684", "R-MMU-375276", "R-RNO-977606", "R-SSC-9856530", "R-MMU-202040", "R-MMU-3296197", "R-HSA-9823730", "R-MMU-428930", "R-HSA-9664535", "R-HSA-1461957", "R-HSA-6783783", "R-MMU-381753", "R-BTA-2485179", "R-RNO-375281", "R-HSA-2514859", "R-CFA-389397", "R-HSA-456926", "R-BTA-373076", "R-CEL-390696", "R-MMU-1461957", "R-CFA-380095", "R-MMU-2453902", "R-HSA-6785807", "R-RNO-391906", "R-BTA-391906", "R-MMU-375280", "R-BTA-416476", "R-DRE-388479", "R-HSA-5683826", "R-SSC-392023", "R-BTA-418555", "R-BTA-418592", "R-SSC-418597", "R-SSC-5620922", "R-MMU-5620922", "R-RNO-392023", "R-HSA-390648", "R-RNO-390666", "R-SSC-419408", "R-RNO-418555", "R-CEL-5620922", "R-HSA-9752946", "R-GGA-418592", "R-CEL-400042", "R-MMU-8856825", "R-DRE-390696", "R-BTA-390651", "R-MMU-380108", "R-BTA-2187335", "R-RNO-417973", "R-HSA-416476", "R-MMU-380095", "R-BTA-375281", "R-HSA-399997", "R-MMU-444821", "R-HSA-9827857", "R-CFA-417973", "R-RNO-392851", "R-HSA-444209", "R-DME-8856828", "R-HSA-9833110", "R-DRE-2514859", "R-HSA-381771", "R-DRE-419771", "R-DME-418597", "R-DME-8856825", "R-HSA-419771", "R-CFA-390666", "R-RNO-2485179", "R-RNO-9706019", "R-HSA-9679191", "R-HSA-444821", "R-CEL-418594", "R-SSC-400042", "R-MMU-418592", "R-HSA-418594", "R-HSA-9022699", "R-DRE-416476", "R-MMU-390648", "R-BTA-5610787", "R-SSC-5683826", "R-HSA-2453902"], "pathways": ["R-HSA-390666:r:Serotonin receptors", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DRE-418597:r:G alpha (z) signalling events", "R-DRE-419408:r:Lysosphingolipid and LPA receptors", "R-HSA-419408:r:Lysosphingolipid and LPA receptors", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-SSC-380108:r:Chemokine receptors bind chemokines", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-GGA-416476:r:G alpha (q) signalling events", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-DRE-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-2187335:r:The retinoid cycle in cones (daylight vision)", "R-MMU-391906:r:Leukotriene receptors", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-391908:r:Prostanoid ligand receptors", "R-CEL-418555:r:G alpha (s) signalling events", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-3296197:r:Hydroxycarboxylic acid-binding receptors", "R-SSC-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-5610787:r:Hedgehog 'off' state", "R-XTR-5610787:r:Hedgehog 'off' state", "R-CEL-391908:r:Prostanoid ligand receptors", "R-SSC-417957:r:P2Y receptors", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-HSA-391906:r:Leukotriene receptors", "R-MMU-9634597:r:GPER1 signaling", "R-MMU-111885:r:Opioid Signalling", "R-HSA-418555:r:G alpha (s) signalling events", "R-CEL-5683826:r:Surfactant metabolism", "R-BTA-418597:r:G alpha (z) signalling events", "R-RNO-391908:r:Prostanoid ligand receptors", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-BTA-392023:r:Adrenaline signalling through Alpha-2 adrenergic receptor", "R-CFA-418594:r:G alpha (i) signalling events", "R-HSA-380108:r:Chemokine receptors bind chemokines", "R-MMU-2187335:r:The retinoid cycle in cones (daylight vision)", "R-MMU-392170:r:ADP signalling through P2Y purinoceptor 12", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-390666:r:Serotonin receptors", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DRE-2485179:r:Activation of the phototransduction cascade", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-391908:r:Prostanoid ligand receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-CFA-419771:r:Opsins", "R-BTA-388479:r:Vasopressin-like receptors", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-MMU-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-RNO-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-9918443:r:Defective visual phototransduction due to OPN1SW loss of function", "R-HSA-5619099:r:Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)", "R-CEL-392023:r:Adrenaline signalling through Alpha-2 adrenergic receptor", "R-RNO-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-GGA-417973:r:Adenosine P1 receptors", "R-HSA-111885:r:Opioid Signalling", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-417973:r:Adenosine P1 receptors", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-SSC-416476:r:G alpha (q) signalling events", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-HSA-3296197:r:Hydroxycarboxylic acid-binding receptors", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-375276:r:Peptide ligand-binding receptors", "R-HSA-5579031:r:Defective ACTH causes obesity and POMCD", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-390650:r:Histamine receptors", "R-SSC-418594:r:G alpha (i) signalling events", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-2187335:r:The retinoid cycle in cones (daylight vision)", "R-GGA-5683826:r:Surfactant metabolism", "R-MMU-390696:r:Adrenoceptors", "R-MMU-418555:r:G alpha (s) signalling events", "R-DME-5689880:r:Ub-specific processing proteases", "R-RNO-444821:r:Relaxin receptors", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-390651:r:Dopamine receptors", "R-MMU-444209:r:Free fatty acid receptors", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-392170:r:ADP signalling through P2Y purinoceptor 12", "R-CEL-6798695:r:Neutrophil degranulation", "R-CFA-391908:r:Prostanoid ligand receptors", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-DME-390648:r:Muscarinic acetylcholine receptors", "R-SSC-419771:r:Opsins", "R-CEL-390648:r:Muscarinic acetylcholine receptors", "R-RNO-390651:r:Dopamine receptors", "R-BTA-418594:r:G alpha (i) signalling events", "R-RNO-375280:r:Amine ligand-binding receptors", "R-HSA-202040:r:G-protein activation", "R-HSA-391903:r:Eicosanoid ligand-binding receptors", "R-SSC-2485179:r:Activation of the phototransduction cascade", "R-MMU-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-417957:r:P2Y receptors", "R-DRE-392023:r:Adrenaline signalling through Alpha-2 adrenergic receptor", "R-DRE-418594:r:G alpha (i) signalling events", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9918436:r:Defective visual phototransduction due to OPN1MW loss of function", "R-RNO-390650:r:Histamine receptors", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-SSC-375281:r:Hormone ligand-binding receptors", "R-HSA-375281:r:Hormone ligand-binding receptors", "R-HSA-391908:r:Prostanoid ligand receptors", "R-CEL-417973:r:Adenosine P1 receptors", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-380108:r:Chemokine receptors bind chemokines", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-428930:r:Thromboxane signalling through TP receptor", "R-DRE-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-RNO-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-392023:r:Adrenaline signalling through Alpha-2 adrenergic receptor", "R-XTR-5632684:r:Hedgehog 'on' state", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-416482:r:G alpha (12/13) signalling events", "R-GGA-418594:r:G alpha (i) signalling events", "R-GGA-375276:r:Peptide ligand-binding receptors", "R-CEL-416476:r:G alpha (q) signalling events", "R-MMU-388479:r:Vasopressin-like receptors", "R-CFA-5683826:r:Surfactant metabolism", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-5610787:r:Hedgehog 'off' state", "R-RNO-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-202040:r:G-protein activation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-390648:r:Muscarinic acetylcholine receptors", "R-HSA-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-380095:r:Tachykinin receptors bind tachykinins", "R-MMU-419771:r:Opsins", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-CEL-375276:r:Peptide ligand-binding receptors", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-CEL-390666:r:Serotonin receptors", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-375281:r:Hormone ligand-binding receptors", "R-CEL-390650:r:Histamine receptors", "R-HSA-5632684:r:Hedgehog 'on' state", "R-RNO-428930:r:Thromboxane signalling through TP receptor", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-DRE-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-380108:r:Chemokine receptors bind chemokines", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-BTA-419771:r:Opsins", "R-SSC-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-BTA-428930:r:Thromboxane signalling through TP receptor", "R-CEL-390651:r:Dopamine receptors", "R-CFA-390696:r:Adrenoceptors", "R-HSA-9036092:r:Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)", "R-DME-390666:r:Serotonin receptors", "R-RNO-390696:r:Adrenoceptors", "R-RNO-202040:r:G-protein activation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CFA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CFA-375281:r:Hormone ligand-binding receptors", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-419408:r:Lysosphingolipid and LPA receptors", "R-HSA-9918450:r:Defective visual phototransduction due to OPN1LW loss of function", "R-MMU-392023:r:Adrenaline signalling through Alpha-2 adrenergic receptor", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DME-390696:r:Adrenoceptors", "R-SSC-390648:r:Muscarinic acetylcholine receptors", "R-DME-390650:r:Histamine receptors", "R-HSA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-MMU-390650:r:Histamine receptors", "R-SSC-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-RNO-444209:r:Free fatty acid receptors", "R-RNO-390648:r:Muscarinic acetylcholine receptors", "R-DME-390651:r:Dopamine receptors", "R-MMU-417973:r:Adenosine P1 receptors", "R-SSC-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-173107:r:Binding and entry of HIV virion", "R-MMU-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-HSA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-RNO-111885:r:Opioid Signalling", "R-HSA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-HSA-390651:r:Dopamine receptors", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-GGA-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-RNO-419771:r:Opsins", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-388479:r:Vasopressin-like receptors", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-417973:r:Adenosine P1 receptors", "R-CFA-375276:r:Peptide ligand-binding receptors", "R-MMU-376176:r:Signaling by ROBO receptors", "R-GGA-418555:r:G alpha (s) signalling events", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-RNO-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-CEL-418597:r:G alpha (z) signalling events", "R-CFA-416476:r:G alpha (q) signalling events", "R-HSA-418597:r:G alpha (z) signalling events", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DME-418555:r:G alpha (s) signalling events", "R-HSA-375280:r:Amine ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-392023:r:Adrenaline signalling through Alpha-2 adrenergic receptor", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-MMU-418597:r:G alpha (z) signalling events", "R-BTA-390696:r:Adrenoceptors", "R-HSA-390696:r:Adrenoceptors", "R-HSA-417957:r:P2Y receptors", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-419771:r:Opsins", "R-RNO-417957:r:P2Y receptors", "R-RNO-419408:r:Lysosphingolipid and LPA receptors", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-5632684:r:Hedgehog 'on' state", "R-GGA-390648:r:Muscarinic acetylcholine receptors", "R-MMU-977606:r:Regulation of Complement cascade", "R-CFA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-388479:r:Vasopressin-like receptors", "R-HSA-376176:r:Signaling by ROBO receptors", "R-BTA-419408:r:Lysosphingolipid and LPA receptors", "R-BTA-380095:r:Tachykinin receptors bind tachykinins", "R-DME-418594:r:G alpha (i) signalling events", "R-DRE-375280:r:Amine ligand-binding receptors", "R-MMU-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CEL-391906:r:Leukotriene receptors", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CFA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-HSA-187024:r:NGF-independant TRKA activation", "R-CFA-390650:r:Histamine receptors", "R-HSA-877300:r:Interferon gamma signaling", "R-CFA-444821:r:Relaxin receptors", "R-SSC-390696:r:Adrenoceptors", "R-GGA-417957:r:P2Y receptors", "R-BTA-5683826:r:Surfactant metabolism", "R-CFA-381753:r:Olfactory Signaling Pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-380095:r:Tachykinin receptors bind tachykinins", "R-MMU-417957:r:P2Y receptors", "R-RNO-418597:r:G alpha (z) signalling 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Junction Complex (EJC)", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000290": {"description": "Colicin immunity protein/pyocin immunity protein", "go_ids": ["GO:0015643", "GO:0030153"], "go_terms": ["GO:0015643:toxic substance binding:F", "GO:0030153:bacteriocin immunity:P"], "name": "Colicin_pyocin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000292": {"description": "Formate/nitrite transporter", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "For/NO2_transpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000293": {"description": "Channel forming colicin, C-terminal cytotoxic", "go_ids": ["GO:0016020", "GO:0050829", "GO:0140911", "GO:0031640"], "go_terms": ["GO:0016020:membrane:C", "GO:0050829:defense response to Gram-negative bacterium:P", "GO:0140911:pore-forming activity:F", "GO:0031640:killing of cells of another organism:P"], "name": "Channel_colicin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000294": {"description": "Gamma-carboxyglutamic acid-rich (GLA) domain", "go_ids": ["GO:0005509", "GO:0005576"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0005576:extracellular region:C"], "name": "GLA_domain", "pathway_ids": ["R-MMU-416476", "R-HSA-159782", "R-MMU-159740", "R-HSA-9672396", "R-BTA-140837", "R-MMU-76009", "R-GGA-159782", "R-HSA-140837", "R-HSA-9918485", "R-HSA-9673202", "R-RNO-140875", "R-MMU-375276", "R-HSA-1368108", "R-MMU-8957275", "R-GGA-140875", "R-RNO-977606", "R-RNO-140837", "R-MMU-456926", "R-RNO-202733", "R-MMU-202733", "R-HSA-9673240", "R-MMU-381426", "R-HSA-9672391", "R-RNO-416476", "R-RNO-159740", "R-HSA-381426", "R-BTA-140834", "R-HSA-9629569", "R-HSA-9673218", "R-CFA-159763", "R-CFA-159782", "R-HSA-456926", "R-MMU-140837", "R-RNO-159763", "R-RNO-381426", "R-HSA-159740", "R-RNO-456926", "R-HSA-9673221", "R-HSA-140834", "R-BTA-159763", "R-HSA-8940973", "R-HSA-9672383", "R-MMU-114608", "R-HSA-9657688", "R-CFA-202733", "R-HSA-375276", "R-RNO-159782", "R-MMU-140834", "R-HSA-416476", "R-BTA-159782", "R-RNO-114608", "R-BTA-202733", "R-XTR-159763", "R-HSA-114608", "R-HSA-76009", "R-BTA-114608", "R-CFA-159740", "R-HSA-977606", "R-RNO-8957275", "R-RNO-140834", "R-MMU-159763", "R-CFA-8957275", "R-HSA-9918481", "R-BTA-159740", "R-HSA-159763", "R-XTR-159740", "R-CFA-381426", "R-GGA-140834", "R-BTA-140875", "R-MMU-977606", "R-XTR-159782", "R-HSA-140875", "R-MMU-140875", "R-RNO-375276", "R-MMU-159782", "R-HSA-8957275", "R-GGA-159763", "R-HSA-202733", "R-CFA-140875"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-GGA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9673202:r:Defective F9 variant does not activate FX", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-GGA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9673240:r:Defective gamma-carboxylation of F9", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-9629569:r:Protein hydroxylation", "R-HSA-9673218:r:Defective F9 secretion", "R-CFA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-CFA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-9673221:r:Defective F9 activation", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-9672383:r:Defective factor IX causes thrombophilia", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-CFA-202733:r:Cell surface interactions at the vascular wall", 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precursors from the endoplasmic reticulum to the Golgi apparatus", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-XTR-159740:r:Gamma-carboxylation of protein precursors", "R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-977606:r:Regulation of Complement cascade", "R-XTR-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-GGA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-CFA-140875:r:Common Pathway of Fibrin Clot Formation"], "type": "Domain"}, "IPR000297": {"description": "Peptidyl-prolyl cis-trans isomerase, PpiC-type", "go_ids": ["GO:0003755"], "go_terms": ["GO:0003755:peptidyl-prolyl cis-trans isomerase activity:F"], "name": "PPIase_PpiC", "pathway_ids": ["R-SPO-6811555", "R-DME-6811555", "R-MMU-6804756", "R-HSA-9760173", "R-HSA-936440", "R-HSA-1169408", "R-HSA-6811555", "R-BTA-6811555", "R-SCE-6811555", "R-DME-6804756", "R-BTA-5668599", "R-HSA-6804756", "R-BTA-936440", "R-BTA-6804756", "R-SPO-5668599", "R-MMU-5668599", "R-MMU-6811555", "R-MMU-936440", "R-SCE-5668599", "R-HSA-5668599"], "pathways": ["R-SPO-6811555:r:PI5P Regulates TP53 Acetylation", "R-DME-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-BTA-6811555:r:PI5P Regulates TP53 Acetylation", "R-SCE-6811555:r:PI5P Regulates TP53 Acetylation", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases"], "type": "Domain"}, "IPR000298": {"description": "Cytochrome c oxidase subunit III-like", "go_ids": ["GO:0004129", "GO:0016020"], "go_terms": ["GO:0004129:cytochrome-c oxidase activity:F", "GO:0016020:membrane:C"], "name": "Cyt_c_oxidase-like_su3", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279", "R-SSC-611105", "R-GGA-9707564", "R-HSA-5419276", "R-SSC-5419276", "R-DRE-611105", "R-DME-9707564", "R-SSC-5628897", "R-DRE-9864848", "R-RNO-5628897", "R-SSC-9864848", "R-RNO-9707564", "R-HSA-5628897", "R-DME-611105", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-GGA-5419276", "R-DME-9864848", "R-SSC-9707564", "R-RNO-5419276", "R-GGA-5628897", "R-HSA-9707564", "R-GGA-611105", "R-MMU-611105", "R-MMU-5628897", "R-MMU-5419276", "R-DME-5419276", "R-MMU-9864848", "R-CEL-5419276", "R-DRE-9707564", "R-DRE-5628897", "R-DME-5628897", "R-MMU-9707564", "R-DRE-5419276"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "R-SSC-611105:r:Respiratory electron transport", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-DRE-611105:r:Respiratory electron transport", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", 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plasma membrane", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-210990:r:PECAM1 interactions", "R-SPO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-202424:r:Downstream TCR signaling", "R-SPO-9013409:r:RHOJ GTPase cycle", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CFA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SCE-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-CFA-912526:r:Interleukin receptor SHC signaling", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells"], "type": "Domain"}, "IPR000301": {"description": "Tetraspanin, animals", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Tetraspanin_animals", "pathway_ids": ["R-MMU-1300645", "R-HSA-6798695", "R-HSA-416993", "R-RNO-446107", "R-MMU-977606", "R-BTA-198933", "R-RNO-1300645", "R-RNO-198933", "R-HSA-1300645", "R-HSA-977225", "R-BTA-1300645", "R-CEL-6798695", "R-BTA-6798695", "R-RNO-114608", "R-RNO-977606", "R-HSA-114608", "R-HSA-9638630", "R-BTA-114608", "R-MMU-198933", "R-HSA-5336415", "R-HSA-2022090", "R-HSA-977606", "R-MMU-6798695", "R-HSA-198933", "R-HSA-446107", "R-BTA-977606", "R-HSA-202733", "R-RNO-6798695", "R-MMU-446107", "R-MMU-114608", "R-MMU-416993"], "pathways": ["R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-BTA-114608:r:Platelet degranulation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-BTA-977606:r:Regulation of Complement cascade", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-MMU-114608:r:Platelet degranulation", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors"], "type": "Family"}, "IPR000304": {"description": "Pyrroline-5-carboxylate reductase-like", "go_ids": ["GO:0004735", "GO:0055129"], "go_terms": ["GO:0004735:pyrroline-5-carboxylate reductase activity:F", 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"go_terms": [], "name": "GIY-YIG_endonuc", "pathway_ids": ["R-MMU-5693568", "R-BTA-5693568", "R-HSA-5693568", "R-HSA-6783310", "R-BTA-6783310", "R-RNO-6783310", "R-RNO-5693568", "R-MMU-6783310"], "pathways": ["R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR000306": {"description": "FYVE zinc finger", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Znf_FYVE", "pathway_ids": ["R-RNO-917729", "R-HSA-9013405", "R-MMU-182971", "R-MMU-8856828", "R-BTA-9706019", "R-MMU-917729", "R-BTA-5689880", "R-MMU-1660516", "R-HSA-8856828", "R-HSA-5689880", "R-MMU-1632852", "R-MMU-9706019", "R-CEL-416482", "R-MMU-5689880", "R-RNO-1632852", "R-HSA-9635644", "R-MMU-9013420", "R-MMU-1660514", "R-CEL-9013148", "R-RNO-193648", "R-HSA-2173789", "R-HSA-168138", "R-HSA-182971", "R-BTA-182971", "R-RNO-432720", "R-HSA-432720", "R-HSA-983231", "R-HSA-416482", "R-RNO-9013148", "R-HSA-1660516", "R-RNO-5689880", "R-HSA-9013149", "R-MMU-193648", "R-HSA-1632852", "R-CEL-1660517", "R-DME-182971", "R-MMU-2173788", "R-RNO-9013420", "R-MMU-1660517", "R-SCE-983231", "R-HSA-1660517", "R-DME-432720", "R-MMU-8856825", "R-BTA-917729", "R-HSA-201451", "R-MMU-9013148", "R-MMU-983231", "R-HSA-1660499", "R-HSA-3656532", "R-HSA-9636383", "R-RNO-416482", "R-HSA-9013148", "R-MMU-201451", "R-DME-8856828", "R-RNO-8856828", "R-MMU-432720", "R-BTA-6807004", "R-DME-917729", "R-CEL-193648", "R-BTA-8856828", "R-BTA-9013420", "R-HSA-193648", "R-DME-8856825", "R-HSA-9013420", 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"R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-1632852:r:Macroautophagy", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DME-182971:r:EGFR downregulation", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-201451:r:Signaling by BMP", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-HSA-9636383:r:Prevention 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"R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6807004:r:Negative regulation of MET activity", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-6807004:r:Negative regulation of MET activity", "R-RNO-182971:r:EGFR downregulation", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR000307": {"description": "Small ribosomal subunit protein bS16", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bS16", "pathway_ids": ["R-BTA-5389840", "R-CEL-9937383", "R-MMU-9937383", "R-HSA-5419276", "R-HSA-5368286", "R-CEL-5389840", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-DME-5389840", "R-HSA-5389840", "R-BTA-9937383", "R-DME-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR000308": {"description": "14-3-3 protein", "go_ids": [], "go_terms": [], "name": "14-3-3", "pathway_ids": ["R-SCE-3371453", "R-HSA-9604323", "R-HSA-6802952", "R-RNO-2028269", "R-CEL-450385", "R-GGA-2565942", "R-BTA-205025", "R-RNO-450513", "R-CEL-5673000", "R-MMU-75035", "R-BTA-6804114", "R-RNO-512988", "R-MMU-380320", "R-BTA-9968551", "R-HSA-5673000", "R-GGA-5675221", 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"R-DME-6804114", "R-CEL-75035", "R-DRE-9614399", "R-RNO-8876198", "R-RNO-5620912", "R-XTR-450513", "R-MMU-205025", "R-HSA-5628897", "R-DME-430116", "R-CEL-3769402", "R-HSA-2565942", "R-DRE-9929491", "R-DDI-75035", "R-CEL-5625740", "R-HSA-6802946", "R-DME-166208", "R-DRE-5675221", "R-XTR-166208", "R-PFA-450604", "R-HSA-5620912", "R-BTA-380284", "R-GGA-380259", "R-DME-170968", "R-MMU-3769402", "R-CEL-6804114", "R-BTA-3769402", "R-DRE-450513", "R-BTA-9013700", "R-RNO-9929491", "R-CEL-5675221", "R-CEL-392517", "R-CEL-9614399", "R-RNO-8854518", "R-MMU-2028269", "R-DME-8876198", "R-GGA-2028269", "R-RNO-75035", "R-DME-450385", "R-DRE-5625740", "R-GGA-166208", "R-GGA-165159", "R-GGA-380320", "R-DME-3371511", "R-DME-9614399", "R-XTR-165159", "R-SPO-3371511", "R-DRE-75035", "R-CEL-2028269", "R-BTA-8854518", "R-BTA-380270", "R-DRE-392517", "R-HSA-165159", "R-RNO-111447", "R-MMU-166208", "R-XTR-5675221", "R-GGA-512988", "R-SCE-3371511", "R-HSA-380259", "R-HSA-2028269", "R-HSA-5675221"], 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"R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-166208:r:mTORC1-mediated signalling", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-165159:r:MTOR signalling", "R-MMU-3371511:r:HSF1 activation", "R-XTR-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-170984:r:ARMS-mediated activation", "R-RNO-165159:r:MTOR signalling", "R-RNO-5673000:r:RAF activation", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-GGA-3371511:r:HSF1 activation", "R-MMU-170968:r:Frs2-mediated activation", "R-MMU-392517:r:Rap1 signalling", "R-CEL-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-205025:r:NADE modulates death signalling", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-3371511:r:HSF1 activation", "R-RNO-3371511:r:HSF1 activation", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-PFA-5673000:r:RAF activation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DRE-5673000:r:RAF activation", "R-GGA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-DME-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-PFA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-DRE-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DME-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-DME-165159:r:MTOR signalling", "R-CEL-170968:r:Frs2-mediated activation", "R-XTR-9614399:r:Regulation of localization of FOXO transcription factors", "R-GGA-5673000:r:RAF activation", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-392517:r:Rap1 signalling", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-BTA-430116:r:GP1b-IX-V activation signalling", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-BTA-3371511:r:HSF1 activation", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-DME-2028269:r:Signaling by Hippo", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-RNO-166208:r:mTORC1-mediated signalling", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-XTR-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-166208:r:mTORC1-mediated signalling", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DME-392517:r:Rap1 signalling", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-RNO-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-BTA-512988:r:Interleukin-3, 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signaling", "R-GGA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-XTR-5673000:r:RAF activation", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DME-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-205025:r:NADE modulates death signalling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-CEL-166208:r:mTORC1-mediated signalling", "R-MMU-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-GGA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SCE-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-GGA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-XTR-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-BTA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-392517:r:Rap1 signalling", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-GGA-170968:r:Frs2-mediated activation", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-170968:r:Frs2-mediated activation", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-392517:r:Rap1 signalling", "R-XTR-392517:r:Rap1 signalling", "R-GGA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-GGA-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-5673000:r:RAF activation", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-DME-5673000:r:RAF activation", "R-DME-5674135:r:MAP2K and MAPK activation", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-9614399:r:Regulation of localization of FOXO transcription factors", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-165159:r:MTOR signalling", "R-GGA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-GGA-430116:r:GP1b-IX-V activation signalling", "R-XTR-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DRE-165159:r:MTOR signalling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DDI-5625740:r:RHO GTPases activate PKNs", "R-SPO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-GGA-8854518:r:AURKA Activation by TPX2", "R-XTR-2028269:r:Signaling by Hippo", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-3371511:r:HSF1 activation", "R-BTA-2028269:r:Signaling by Hippo", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-CEL-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DRE-9614399:r:Regulation of localization of FOXO transcription factors", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-205025:r:NADE modulates death signalling", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-430116:r:GP1b-IX-V activation signalling", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-CEL-5625740:r:RHO GTPases activate PKNs", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-166208:r:mTORC1-mediated signalling", "R-DRE-5675221:r:Negative regulation of MAPK pathway", "R-XTR-166208:r:mTORC1-mediated signalling", "R-PFA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-DME-170968:r:Frs2-mediated activation", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-BTA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DRE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-CEL-392517:r:Rap1 signalling", "R-CEL-9614399:r:Regulation of localization of FOXO transcription factors", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-2028269:r:Signaling by Hippo", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-GGA-2028269:r:Signaling by Hippo", "R-RNO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-GGA-166208:r:mTORC1-mediated signalling", "R-GGA-165159:r:MTOR signalling", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-3371511:r:HSF1 activation", "R-DME-9614399:r:Regulation of localization of FOXO transcription factors", "R-XTR-165159:r:MTOR signalling", "R-SPO-3371511:r:HSF1 activation", "R-DRE-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-CEL-2028269:r:Signaling by Hippo", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-392517:r:Rap1 signalling", "R-HSA-165159:r:MTOR signalling", "R-RNO-111447:r:Activation of BAD and translocation to mitochondria", "R-MMU-166208:r:mTORC1-mediated signalling", "R-XTR-5675221:r:Negative regulation of MAPK pathway", "R-GGA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SCE-3371511:r:HSF1 activation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR000310": {"description": "Orn/Lys/Arg decarboxylase, major domain", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Orn/Lys/Arg_deCO2ase_major_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000312": {"description": "Glycosyl transferase, family 3", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "Glycosyl_Trfase_fam3", "pathway_ids": ["R-RNO-73621", "R-MMU-73614", "R-HSA-73621", "R-HSA-73614", "R-MMU-73621", "R-RNO-73614"], "pathways": ["R-RNO-73621:r:Pyrimidine catabolism", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-73614:r:Pyrimidine salvage"], "type": "Domain"}, "IPR000313": {"description": "PWWP domain", "go_ids": [], "go_terms": [], "name": "PWWP_dom", "pathway_ids": ["R-HSA-4655427", "R-HSA-180910", "R-HSA-9772755", "R-RNO-3214858", "R-HSA-427413", "R-HSA-5693565", "R-MMU-212300", "R-HSA-3214858", "R-HSA-5632928", "R-MMU-5693565", "R-HSA-6804758", "R-MMU-69473", "R-BTA-9772755", "R-RNO-212300", "R-HSA-114608", "R-HSA-5693607", "R-HSA-162592", "R-HSA-3214841", "R-MMU-4655427", "R-RNO-9772755", "R-HSA-9845323", "R-DME-6804758", "R-MMU-9772755", "R-HSA-5334118", "R-MMU-5358565", "R-MMU-5693607", "R-MMU-3214847", "R-HSA-381038", "R-MMU-3214841", "R-HSA-69473", "R-DME-114608", "R-MMU-3214858", "R-HSA-180689", "R-HSA-164843", "R-HSA-9710421", "R-HSA-5693571", "R-HSA-212300", "R-HSA-5632968", "R-HSA-177539", "R-MMU-6804758", "R-HSA-175567", "R-HSA-3214847", "R-HSA-5358565", "R-HSA-5689603", "R-MMU-5693571", "R-MMU-114608"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-HSA-114608:r:Platelet degranulation", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-162592:r:Integration of provirus", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5334118:r:DNA methylation", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DME-114608:r:Platelet degranulation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-9710421:r:Defective pyroptosis", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR000315": {"description": "B-box-type zinc finger", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_B-box", "pathway_ids": ["R-HSA-9705671", "R-HSA-168928", "R-HSA-933542", "R-MMU-8934593", "R-MMU-9755511", "R-HSA-936440", "R-DDI-9013149", "R-DRE-983168", "R-HSA-6804758", "R-HSA-918233", "R-DDI-381676", "R-HSA-9615017", "R-HSA-2173795", "R-RNO-212436", "R-BTA-3134975", "R-DDI-171007", "R-DRE-9843940", "R-HSA-8948747", "R-HSA-445355", "R-DME-6798695", "R-DDI-392517", "R-HSA-983168", "R-MMU-844456", "R-DRE-3899300", "R-DDI-983168", "R-HSA-9754189", "R-HSA-933541", "R-HSA-933543", "R-HSA-877300", "R-MMU-983168", "R-HSA-9843940", "R-HSA-3899300", "R-DDI-1169092", "R-BTA-983168", "R-MMU-2173795", "R-DDI-354192", "R-HSA-9920588", "R-HSA-6802952", "R-HSA-5689896", "R-HSA-1834941", "R-BTA-9755511", "R-MMU-8948751", "R-DDI-8951664", "R-HSA-9635465", "R-DDI-9013423", "R-HSA-9616222", "R-HSA-5655302", "R-HSA-212436", "R-RNO-3899300", "R-DDI-193648", "R-MMU-9843940", "R-DDI-5658442", "R-HSA-9660826", "R-MMU-3134975", "R-MMU-8948747", "R-HSA-9755511", "R-DDI-5673001", "R-HSA-9609690", "R-RNO-844456", "R-HSA-8934593", "R-HSA-3232142", "R-DDI-4641258", "R-HSA-3134975", "R-MMU-6804758", "R-HSA-8948751", "R-RNO-9843940", "R-MMU-3108214", "R-RNO-983168", "R-HSA-844456", "R-HSA-1839117", "R-DME-983168", "R-MMU-3232142", "R-HSA-901032", "R-HSA-3108214", "R-DDI-9755511", "R-MMU-212436"], "pathways": ["R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-212436:r:Generic Transcription Pathway", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DDI-171007:r:p38MAPK events", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-445355:r:Smooth Muscle Contraction", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-392517:r:Rap1 signalling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-844456:r:The NLRP3 inflammasome", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-DDI-1169092:r:Activation of RAS in B cells", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DDI-354192:r:Integrin signaling", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DDI-8951664:r:Neddylation", "R-HSA-9635465:r:Suppression of apoptosis", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-212436:r:Generic Transcription Pathway", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-844456:r:The NLRP3 inflammasome", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-212436:r:Generic Transcription Pathway"], "type": "Domain"}, "IPR000316": {"description": "Plant EC metallothionein-like protein, family 15", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Metallthion_15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000317": {"description": "Peptidase C24, Calicivirus polyprotein Orf1", "go_ids": ["GO:0004197", "GO:0006508"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_C24", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR000320": {"description": "Hedgehog, N-terminal signalling domain", "go_ids": ["GO:0007267"], "go_terms": ["GO:0007267:cell-cell signaling:P"], "name": "Hedgehog_signalling_dom", "pathway_ids": ["R-HSA-373080", "R-DRE-5358346", "R-MMU-5635838", "R-DME-5362798", "R-GGA-5632681", "R-HSA-9937080", "R-GGA-5358346", "R-RNO-5632681", "R-HSA-5632684", "R-DRE-5362798", "R-DME-5632681", "R-DME-209338", "R-DME-209471", "R-MMU-5632681", "R-HSA-5632681", "R-HSA-5362798", "R-HSA-8941284", "R-MMU-5362798", "R-HSA-5635838", "R-DRE-5632681", "R-MMU-5358346", "R-HSA-9758920", "R-HSA-5362768", "R-HSA-9796292", "R-HSA-5658034", "R-RNO-5362798", "R-GGA-5362798", "R-RNO-5358346", "R-HSA-9690406", "R-DME-5358346", "R-HSA-5358346"], "pathways": ["R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5635838:r:Activation of SMO", "R-DME-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5632681:r:Ligand-receptor interactions", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-DME-5632681:r:Ligand-receptor interactions", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-5632681:r:Ligand-receptor interactions", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-5635838:r:Activation of SMO", "R-DRE-5632681:r:Ligand-receptor interactions", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-5658034:r:HHAT G278V doesn't palmitoylate Hh-Np", "R-RNO-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Domain"}, "IPR000322": {"description": "Glycoside hydrolase family 31, TIM barrel domain", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_31_TIM", "pathway_ids": ["R-MMU-70221", "R-HSA-6798695", "R-HSA-189085", "R-SPO-6798695", "R-HSA-70221", "R-HSA-532668", "R-HSA-9683686", "R-HSA-9694548", "R-HSA-5357609", "R-MMU-9768727", "R-BTA-6798695", "R-MMU-189085", "R-RNO-70221", "R-SPO-189085", "R-SPO-70221", "R-HSA-5659898", "R-MMU-6798695", "R-RNO-189085", "R-HSA-9768727", "R-HSA-901042", "R-SSC-189085", "R-RNO-6798695", "R-BTA-70221"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-5357609:r:Glycogen storage disease type II (GAA)", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-SPO-189085:r:Digestion of dietary carbohydrate", "R-SPO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-5659898:r:Intestinal saccharidase deficiencies", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-SSC-189085:r:Digestion of dietary carbohydrate", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-70221:r:Glycogen breakdown (glycogenolysis)"], "type": "Domain"}, "IPR000323": {"description": "Copper type II, ascorbate-dependent monooxygenase, N-terminal", "go_ids": ["GO:0004497", "GO:0005507", "GO:0016715"], "go_terms": ["GO:0004497:monooxygenase activity:F", "GO:0005507:copper ion binding:F", "GO:0016715:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen:F"], "name": "Cu2_ascorb_mOase_N", "pathway_ids": ["R-CFA-209905", "R-DME-209905", "R-HSA-209905", "R-RNO-209905", "R-MMU-209905"], "pathways": ["R-CFA-209905:r:Catecholamine biosynthesis", "R-DME-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-RNO-209905:r:Catecholamine biosynthesis", "R-MMU-209905:r:Catecholamine biosynthesis"], "type": "Domain"}, "IPR000326": {"description": "Phosphatidic acid phosphatase type 2/haloperoxidase", "go_ids": [], "go_terms": [], "name": "PAP2/HPO", "pathway_ids": ["R-DDI-419408", "R-SCE-9845614", "R-SPO-2029485", "R-BTA-9845614", "R-DRE-419408", "R-HSA-419408", "R-DME-419408", "R-RNO-9845614", "R-SPO-419408", "R-SCE-2029485", "R-DDI-446199", "R-HSA-2029485", "R-MMU-70263", "R-XTR-419408", "R-MMU-419408", "R-DRE-9969896", "R-HSA-9615017", "R-HSA-70263", "R-SPO-9845614", "R-MMU-2029485", "R-BTA-9969896", "R-DDI-2029485", "R-SCE-419408", "R-HSA-3274531", "R-HSA-9969896", "R-RNO-419408", "R-DRE-70263", "R-DME-9845614", "R-CEL-9845614", "R-MMU-9969896", "R-CEL-419408", "R-MMU-9845614", "R-HSA-446199", "R-DDI-9845614", "R-SSC-9845614", "R-SPO-446199", "R-BTA-70263", "R-HSA-9845614", "R-MMU-446199", "R-HSA-3282872", "R-RNO-9969896", "R-RNO-70263"], "pathways": ["R-DDI-419408:r:Lysosphingolipid and LPA receptors", "R-SCE-9845614:r:Sphingolipid catabolism", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-9845614:r:Sphingolipid catabolism", "R-DRE-419408:r:Lysosphingolipid and LPA receptors", "R-HSA-419408:r:Lysosphingolipid and LPA receptors", "R-DME-419408:r:Lysosphingolipid and LPA receptors", "R-RNO-9845614:r:Sphingolipid catabolism", "R-SPO-419408:r:Lysosphingolipid and LPA receptors", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-70263:r:Gluconeogenesis", "R-XTR-419408:r:Lysosphingolipid and LPA receptors", "R-MMU-419408:r:Lysosphingolipid and LPA receptors", "R-DRE-9969896:r:Lanosterol biosynthesis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-70263:r:Gluconeogenesis", "R-SPO-9845614:r:Sphingolipid catabolism", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-419408:r:Lysosphingolipid and LPA receptors", "R-HSA-3274531:r:Glycogen storage disease type Ia (G6PC)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-RNO-419408:r:Lysosphingolipid and LPA receptors", "R-DRE-70263:r:Gluconeogenesis", "R-DME-9845614:r:Sphingolipid catabolism", "R-CEL-9845614:r:Sphingolipid catabolism", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-CEL-419408:r:Lysosphingolipid and LPA receptors", "R-MMU-9845614:r:Sphingolipid catabolism", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-DDI-9845614:r:Sphingolipid catabolism", "R-SSC-9845614:r:Sphingolipid catabolism", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-70263:r:Gluconeogenesis", "R-HSA-9845614:r:Sphingolipid catabolism", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-3282872:r:Severe congenital neutropenia type 4 (G6PC3)", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR000327": {"description": "POU-specific domain", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", 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"R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-1266695:r:Interleukin-7 signaling", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5689603:r:UCH proteinases", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-SCE-6782135:r:Dual incision in TC-NER", "R-CEL-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-6782135:r:Dual incision in TC-NER", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-5689603:r:UCH proteinases", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5689603:r:UCH proteinases", "R-RNO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR000331": {"description": "Rap/Ran-GAP domain", "go_ids": ["GO:0005096", "GO:0051056"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0051056:regulation of small GTPase mediated signal transduction:P"], "name": "Rap/Ran_GAP_dom", "pathway_ids": ["R-RNO-8854214", "R-MMU-9013407", "R-HSA-8854214", "R-MMU-380972", "R-HSA-5674400", "R-MMU-198323", "R-MMU-392517", "R-MMU-1632852", "R-RNO-9013407", "R-MMU-8853659", "R-RNO-5628897", "R-RNO-165181", "R-DDI-392517", "R-SPO-5628897", "R-HSA-380972", "R-SPO-380972", "R-SPO-165181", "R-HSA-5628897", "R-MMU-8854214", "R-SPO-198323", "R-HSA-6794361", "R-HSA-198323", "R-RNO-1632852", "R-MMU-165181", "R-HSA-8853659", "R-RNO-380972", "R-HSA-1445148", "R-HSA-1632852", "R-MMU-5628897", "R-RNO-198323", "R-HSA-165181", "R-HSA-392517", "R-HSA-9013407", "R-DME-9013407"], "pathways": ["R-RNO-8854214:r:TBC/RABGAPs", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-392517:r:Rap1 signalling", "R-MMU-1632852:r:Macroautophagy", "R-RNO-9013407:r:RHOH GTPase cycle", "R-MMU-8853659:r:RET signaling", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-DDI-392517:r:Rap1 signalling", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-8854214:r:TBC/RABGAPs", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-1632852:r:Macroautophagy", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-8853659:r:RET signaling", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-1632852:r:Macroautophagy", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DME-9013407:r:RHOH GTPase cycle"], "type": "Domain"}, "IPR000333": {"description": "Ser/Thr protein kinase, TGFB receptor", "go_ids": ["GO:0004675", "GO:0005524", "GO:0007178", "GO:0016020"], "go_terms": ["GO:0004675:transmembrane receptor protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0007178:cell surface receptor protein serine/threonine kinase signaling pathway:P", "GO:0016020:membrane:C"], "name": "TGFB_receptor", "pathway_ids": ["R-DME-2173789", "R-MMU-9839406", "R-HSA-9839406", "R-GGA-2173789", "R-DME-1502540", "R-BTA-5689880", "R-HSA-3656535", "R-DME-2173788", "R-HSA-5689880", "R-BTA-201451", "R-HSA-201451", "R-MMU-2173791", "R-GGA-1502540", "R-RNO-2173788", "R-BTA-2173789", "R-HSA-3656532", "R-MMU-5689880", "R-HSA-9839389", "R-BTA-9839389", "R-HSA-1181150", "R-MMU-201451", "R-RNO-201451", "R-RNO-9839389", "R-RNO-2173789", "R-HSA-2173789", "R-MMU-1502540", "R-HSA-3645790", "R-CEL-2173788", "R-GGA-2173788", "R-MMU-2173789", "R-MMU-9839389", "R-HSA-2173791", "R-BTA-2173791", "R-GGA-201451", "R-HSA-3304356", "R-BTA-1502540", "R-HSA-1502540", "R-BTA-2173788", "R-BTA-9839406", "R-DME-2173791", "R-RNO-5689880", "R-RNO-2173791", "R-GGA-2173791", "R-GGA-9839406", "R-DME-9839389", "R-GGA-9839389", "R-RNO-1502540", "R-HSA-5689603", "R-HSA-3642279", "R-CEL-2173789", "R-DME-201451", "R-HSA-2173788", "R-MMU-2173788", "R-HSA-1433617", "R-RNO-9839406", "R-DME-5689880"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-GGA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-1502540:r:Signaling by Activin", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-1502540:r:Signaling by Activin", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-1181150:r:Signaling by NODAL", "R-MMU-201451:r:Signaling by BMP", "R-RNO-201451:r:Signaling by BMP", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-1502540:r:Signaling by Activin", "R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-201451:r:Signaling by BMP", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-BTA-1502540:r:Signaling by Activin", "R-HSA-1502540:r:Signaling by Activin", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-9839406:r:TGFBR3 regulates activin signaling", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-9839406:r:TGFBR3 regulates activin signaling", "R-DME-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-GGA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-1502540:r:Signaling by Activin", "R-HSA-5689603:r:UCH proteinases", "R-HSA-3642279:r:TGFBR2 MSI Frameshift Mutants in Cancer", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-201451:r:Signaling by BMP", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-RNO-9839406:r:TGFBR3 regulates activin signaling", "R-DME-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR000334": {"description": "Glycoside hydrolase, family 45", "go_ids": ["GO:0005975", "GO:0008810"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0008810:cellulase activity:F"], "name": "Glyco_hydro_45", "pathway_ids": ["PWY-6788"], "pathways": ["PWY-6788:t:cellulose degradation II (fungi)"], "type": "Domain"}, "IPR000335": {"description": "Bleomycin resistance protein", "go_ids": ["GO:0046677"], "go_terms": ["GO:0046677:response to antibiotic:P"], "name": "Bleomycin-R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000336": {"description": "Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Flavivir/Alphavir_Ig-like_sf", "pathway_ids": ["R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Homologous_superfamily"}, "IPR000340": {"description": "Dual specificity phosphatase, catalytic domain", "go_ids": ["GO:0016311"], "go_terms": ["GO:0016311:dephosphorylation:P"], "name": "Dual-sp_phosphatase_cat-dom", "pathway_ids": ["R-SCE-1855204", "R-DDI-8873719", "R-BTA-202670", "R-SPO-5687128", "R-SCE-8948747", "R-HSA-3785653", "R-HSA-72086", "R-CEL-72086", "R-CEL-202670", "R-HSA-1483148", "R-DRE-77075", "R-SCE-8948751", "R-DRE-176407", "R-MMU-112409", "R-HSA-3322077", "R-CEL-112409", "R-DDI-112409", "R-SPO-176407", "R-HSA-77075", "R-SCE-176407", "R-MMU-202670", "R-DME-112409", "R-DRE-5687128", "R-GGA-437980", "R-HSA-202670", "R-CEL-5675221", "R-SCE-1660499", "R-DRE-72086", "R-SCE-202670", "R-BTA-112409", "R-RNO-5675221", "R-DME-202670", "R-CEL-77075", "R-DDI-5675221", "R-RNO-112409", "R-HSA-9636569", "R-DDI-202670", "R-RNO-202670", "R-BTA-5675221", "R-DME-5675221", "R-HSA-9652817", "R-MMU-77075", "R-HSA-112409", "R-HSA-167160", "R-SCE-199418", "R-SPO-202670", "R-MMU-72086", "R-SCE-5687128", "R-GGA-437986", "R-SCE-202424", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DDI-8873719:r:RAB geranylgeranylation", "R-BTA-202670:r:ERKs are inactivated", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-8948747:r:Regulation of PTEN localization", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-HSA-72086:r:mRNA Capping", "R-CEL-72086:r:mRNA Capping", "R-CEL-202670:r:ERKs are inactivated", "R-HSA-1483148:r:Synthesis of PG", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-DRE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-3322077:r:Glycogen synthesis", "R-CEL-112409:r:RAF-independent MAPK1/3 activation", "R-DDI-112409:r:RAF-independent MAPK1/3 activation", "R-SPO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-202670:r:ERKs are inactivated", "R-DME-112409:r:RAF-independent MAPK1/3 activation", "R-DRE-5687128:r:MAPK6/MAPK4 signaling", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-HSA-202670:r:ERKs are inactivated", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-72086:r:mRNA Capping", "R-SCE-202670:r:ERKs are inactivated", "R-BTA-112409:r:RAF-independent MAPK1/3 activation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-DME-202670:r:ERKs are inactivated", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-9636569:r:Suppression of autophagy", "R-DDI-202670:r:ERKs are inactivated", "R-RNO-202670:r:ERKs are inactivated", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9652817:r:Signaling by MAPK mutants", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-SCE-199418:r:Negative regulation of the PI3K/AKT network", "R-SPO-202670:r:ERKs are inactivated", "R-MMU-72086:r:mRNA Capping", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-SCE-202424:r:Downstream TCR signaling", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR000341": {"description": "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain", "go_ids": [], "go_terms": [], "name": "PI3K_Ras-bd_dom", 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"pathways": [], "type": "Family"}, "IPR000352": {"description": "Peptide chain release factor class I", "go_ids": ["GO:0003747", "GO:0006415"], "go_terms": ["GO:0003747:translation release factor activity:F", "GO:0006415:translational termination:P"], "name": "Pep_chain_release_fac_I", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Domain"}, "IPR000353": {"description": "MHC class II, beta chain, N-terminal", "go_ids": ["GO:0006955", "GO:0016020", "GO:0019882", "GO:0042613"], "go_terms": ["GO:0006955:immune response:P", "GO:0016020:membrane:C", "GO:0019882:antigen processing and presentation:P", "GO:0042613:MHC class II protein complex:C"], "name": "MHC_II_b_N", "pathway_ids": ["R-MMU-389948", "R-MMU-202433", "R-HSA-2132295", "R-RNO-2132295", "R-HSA-202433", "R-RNO-202433", "R-MMU-202430", "R-HSA-202427", "R-RNO-202427", "R-HSA-202424", "R-HSA-877300", "R-MMU-2132295", "R-RNO-389948", "R-RNO-202424", "R-MMU-202427", "R-RNO-202430", "R-HSA-202430", "R-HSA-389948", "R-MMU-202424"], "pathways": ["R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-202433:r:Generation of second messenger molecules", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-202433:r:Generation of second messenger molecules", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-389948:r:Co-inhibition by PD-1", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-389948:r:Co-inhibition by PD-1", "R-MMU-202424:r:Downstream TCR signaling"], "type": "Domain"}, "IPR000354": {"description": "Involucrin repeat", "go_ids": ["GO:0005737", "GO:0031424"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0031424:keratinization:P"], "name": "Involucrin_rpt", "pathway_ids": ["R-HSA-9725554", "R-HSA-6809371"], "pathways": ["R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Repeat"}, "IPR000357": {"description": "HEAT repeat", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "HEAT", "pathway_ids": ["R-SSC-5673000", "R-DME-69273", "R-HSA-9833482", "R-MMU-6811558", "R-MMU-1632852", "R-CEL-195253", "R-SSC-69231", "R-CEL-5673000", "R-SPO-975957", "R-MMU-68877", "R-HSA-69231", "R-HSA-9639288", "R-SSC-4641262", "R-MMU-380320", "R-SSC-9833482", "R-HSA-5673000", "R-RNO-6811558", "R-HSA-5467337", "R-HSA-192905", "R-SSC-2565942", "R-DME-1295596", "R-SSC-196299", "R-DDI-198753", "R-MMU-5620912", "R-CEL-69231", "R-SSC-1295596", "R-RNO-5673000", "R-HSA-5358752", "R-HSA-198753", "R-SSC-8854518", "R-HSA-163767", "R-HSA-202670", "R-SSC-389356", "R-DDI-113501", "R-MMU-196299", "R-MMU-380259", "R-SPO-6811558", "R-DME-209461", "R-SSC-432142", "R-CEL-2995383", "R-MMU-5673000", "R-HSA-141444", "R-MMU-380270", "R-RNO-5675221", "R-RNO-5663220", "R-RNO-180024", "R-RNO-202670", "R-HSA-9634600", "R-DME-5675221", "R-RNO-6804757", "R-HSA-389356", "R-DME-432620", "R-HSA-1295596", "R-SSC-975957", "R-MMU-4641262", "R-CEL-6811558", "R-MMU-69273", "R-MMU-5663220", "R-RNO-141444", "R-MMU-9860927", "R-MMU-5675221", "R-HSA-2467813", "R-DME-432553", "R-RNO-4641262", "R-DME-2995383", "R-DDI-165159", "R-MMU-380972", "R-SSC-202670", "R-MMU-380284", "R-HSA-196299", "R-RNO-9860927", "R-HSA-166208", "R-DME-209396", "R-HSA-68877", "R-HSA-4641262", "R-SSC-195253", "R-SSC-2995383", "R-SSC-9860927", "R-MMU-202670", "R-DME-389513", "R-SSC-9648025", "R-MMU-195253", "R-HSA-195253", "R-HSA-389513", "R-SSC-389513", "R-HSA-113501", "R-CEL-69273", "R-DDI-9833482", "R-DME-209360", "R-DDI-9639288", "R-DDI-5628897", "R-RNO-68877", "R-DDI-1632852", "R-DDI-69231", "R-MMU-975957", "R-MMU-6804757", "R-DDI-166208", "R-MMU-113501", "R-HSA-2995383", "R-DME-432626", "R-HSA-380270", "R-MMU-3371571", "R-DDI-5675221", "R-RNO-69273", "R-RNO-69231", "R-MMU-389513", "R-DME-9833482", "R-MMU-8943724", "R-HSA-975957", "R-CEL-196299", "R-HSA-3371571", "R-HSA-5663220", "R-RNO-9648025", "R-MMU-198753", "R-DME-975957", "R-RNO-195253", "R-SSC-180024", "R-SSC-5620912", "R-RNO-9833482", "R-DME-209155", "R-SSC-198753", "R-SSC-5663220", "R-SSC-5675221", "R-CEL-975957", "R-MMU-2467813", "R-DME-69231", "R-HSA-69273", "R-HSA-432142", "R-HSA-380284", "R-CEL-113501", "R-MMU-9639288", "R-HSA-8854518", "R-MMU-1295596", "R-DME-113501", "R-MMU-2565942", "R-SSC-6811558", "R-MMU-432142", "R-HSA-380320", "R-MMU-389356", "R-MMU-9833482", "R-HSA-5358747", "R-RNO-196299", "R-HSA-6804757", "R-HSA-8943724", "R-MMU-5628897", "R-DME-5673000", "R-DME-209413", "R-HSA-5358749", "R-MMU-141444", "R-SSC-380259", "R-CEL-9860927", "R-MMU-165159", "R-CEL-389513", "R-CEL-9833482", "R-DDI-380972", "R-HSA-9648025", "R-HSA-5467340", "R-HSA-6811558", "R-SSC-380284", "R-SPO-389513", "R-RNO-113501", "R-RNO-389513", "R-HSA-2465910", "R-HSA-1632852", "R-MMU-8854518", "R-SSC-113501", "R-RNO-2467813", "R-HSA-9860927", "R-SPO-202670", "R-RNO-432142", "R-MMU-69231", "R-HSA-5358751", "R-SSC-380270", "R-SPO-198753", "R-SCE-9639288", "R-RNO-2500257", "R-DDI-69273", "R-DDI-6811558", "R-HSA-5467348", "R-SSC-68877", "R-DME-9860927", "R-HSA-5628897", "R-DME-195253", "R-HSA-2565942", "R-DME-6811558", "R-DME-209214", "R-MMU-180024", "R-HSA-5339716", "R-DDI-389513", "R-HSA-9920951", "R-SPO-69273", "R-HSA-5620912", "R-MMU-9648025", "R-SCE-3371571", "R-SSC-141444", "R-HSA-180024", "R-MMU-2995383", "R-HSA-380972", "R-DME-209190", "R-MMU-2500257", "R-SSC-69273", "R-HSA-2500257", "R-CEL-5675221", "R-SCE-450513", "R-DME-196299", "R-DDI-3371571", "R-SSC-2467813", "R-RNO-389356", "R-DDI-202670", "R-DDI-8943724", "R-DME-209440", "R-MMU-166208", "R-HSA-165159", "R-SSC-380320", "R-RNO-198753", "R-SSC-2500257", "R-HSA-380259", "R-HSA-5675221"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-1632852:r:Macroautophagy", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-69231:r:Cyclin D associated events in G1", "R-CEL-5673000:r:RAF activation", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-SSC-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-9833482:r:PKR-mediated signaling", "R-HSA-5673000:r:RAF activation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-HSA-192905:r:vRNP Assembly", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-SSC-196299:r:Beta-catenin phosphorylation cascade", "R-DDI-198753:r:ERK/MAPK targets", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-CEL-69231:r:Cyclin D associated events in G1", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-RNO-5673000:r:RAF activation", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-198753:r:ERK/MAPK targets", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-HSA-202670:r:ERKs are inactivated", "R-SSC-389356:r:Co-stimulation by CD28", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-SSC-432142:r:Platelet sensitization by LDL", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-5673000:r:RAF activation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-180024:r:DARPP-32 events", "R-RNO-202670:r:ERKs are inactivated", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-389356:r:Co-stimulation by CD28", "R-DME-432620:r:Dephosphorylation of PER", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-165159:r:MTOR signalling", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SSC-202670:r:ERKs are inactivated", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-166208:r:mTORC1-mediated signalling", "R-DME-209396:r:Phosphorylation of ARM", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SSC-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-202670:r:ERKs are inactivated", "R-DME-389513:r:Co-inhibition by CTLA4", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-9833482:r:PKR-mediated signaling", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-68877:r:Mitotic Prometaphase", "R-DDI-1632852:r:Macroautophagy", "R-DDI-69231:r:Cyclin D associated events in G1", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-432626:r:Circadian Clock pathway", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-198753:r:ERK/MAPK targets", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-180024:r:DARPP-32 events", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-SSC-198753:r:ERK/MAPK targets", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-432142:r:Platelet sensitization by LDL", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5673000:r:RAF activation", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-165159:r:MTOR signalling", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-CEL-9833482:r:PKR-mediated signaling", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-SSC-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SPO-202670:r:ERKs are inactivated", "R-RNO-432142:r:Platelet sensitization by LDL", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SPO-198753:r:ERK/MAPK targets", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-SSC-68877:r:Mitotic Prometaphase", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-209214:r:Phosphorylation of SMO", "R-MMU-180024:r:DARPP-32 events", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-180024:r:DARPP-32 events", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-209190:r:Phosphorylation of CI", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-RNO-389356:r:Co-stimulation by CD28", "R-DDI-202670:r:ERKs are inactivated", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-MMU-166208:r:mTORC1-mediated signalling", "R-HSA-165159:r:MTOR signalling", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-198753:r:ERK/MAPK targets", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Repeat"}, "IPR000358": {"description": "Ribonucleotide reductase small subunit family", "go_ids": ["GO:0009263"], "go_terms": ["GO:0009263:deoxyribonucleotide biosynthetic process:P"], "name": "RNR_small_fam", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210", "R-DRE-499943", "R-DME-499943", "R-HSA-69205", "R-MMU-499943", "R-CEL-499943", "R-HSA-8953750", "R-HSA-499943", "R-RNO-499943", "R-HSA-5628897"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Family"}, "IPR000361": {"description": "Core domain, A-type assembly protein ATAP", "go_ids": [], "go_terms": [], "name": "ATAP_core_dom", "pathway_ids": ["R-RNO-9854311", "R-HSA-1362409", "R-HSA-9854311", "R-BTA-9854311", "R-SCE-1362409", "R-RNO-1362409", "R-MMU-9854311", "R-MMU-1362409", "R-BTA-1362409", "R-DDI-1362409", "R-SPO-1362409", "R-DME-1362409"], "pathways": ["R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-BTA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DDI-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", 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"R-HSA-2022870", "R-BTA-1474228", "R-DME-214862", "R-HSA-1971475", "R-HSA-2022857", "R-HSA-418555", "R-GGA-2022857", "R-HSA-373752", "R-RNO-2022857", "R-XTR-4641263", "R-HSA-3656244", "R-DME-214874", "R-MMU-376176", "R-HSA-2022923", "R-CEL-376176", "R-HSA-3656225", "R-MMU-216083", "R-RNO-388844", "R-MMU-2024101", "R-DME-9010553", "R-CFA-2022870", "R-RNO-216083", "R-HSA-9845620", "R-MMU-430116", "R-RNO-1257604", "R-HSA-3595172", "R-DME-214863", "R-MMU-388844", "R-MMU-9034793", "R-HSA-388844", "R-CEL-9010553", "R-HSA-5620916", "R-DRE-2022857", "R-CEL-2243919", "R-HSA-9028335", "R-HSA-3595177", "R-HSA-9032845", "R-RNO-2022870", "R-DME-376176", "R-MMU-977606", "R-HSA-9603505", "R-HSA-8985801", "R-RNO-9603381", "R-HSA-4641263", "R-MMU-9028731", "R-HSA-376176", "R-DME-6798695", "R-XTR-5654687", "R-HSA-9034864", "R-MMU-1257604", "R-HSA-6807004", "R-DME-8941413", "R-MMU-2022857", "R-HSA-9034013", "R-HSA-193634", "R-DME-209968", "R-RNO-9032759", "R-HSA-187024", "R-CEL-8941413", "R-MMU-5654687", "R-MMU-9032759", "R-HSA-428540", "R-RNO-2022854", "R-MMU-6807004", "R-HSA-428890", "R-BTA-216083", "R-MMU-418555", "R-HSA-3595174", "R-MMU-4641263", "R-MMU-76009", "R-CEL-6798695", "R-HSA-430116", "R-HSA-9026519", "R-MMU-3000178", "R-BTA-2022870", "R-CFA-2024101", "R-HSA-177929", "R-BTA-2022854", "R-RNO-9034013", "R-RNO-9026527", "R-DME-214844", "R-RNO-3000178", "R-MMU-2022923", "R-MMU-193634", "R-HSA-381426", "R-MMU-1474228", "R-HSA-2024101", "R-MMU-5620916", "R-RNO-375281", "R-GGA-216083", "R-HSA-9034793", "R-MMU-140837", "R-HSA-9024909", "R-HSA-2219530", "R-MMU-2022854", "R-HSA-3560801", "R-RNO-381426", "R-HSA-375281", "R-HSA-75892", "R-HSA-6811558", "R-HSA-2022854", "R-HSA-9673221", "R-CFA-1474228", "R-HSA-3656243", "R-HSA-4420332", "R-GGA-5654687", "R-RNO-6794361", "R-HSA-1257604", "R-CFA-2022923", "R-RNO-9028731", "R-MMU-9034013", "R-CEL-209968", "R-MMU-2022870", "R-RNO-430116", "R-HSA-9725554", "R-HSA-9034015", "R-HSA-5654687", "R-MMU-9010553", "R-BTA-3000178", "R-HSA-6794361", "R-GGA-2022854", "R-HSA-9032759", "R-HSA-76009", "R-HSA-977606", "R-RNO-2024101", "R-CFA-1971475", "R-RNO-5654687", "R-DME-428890", "R-BTA-2024101", "R-HSA-9025046", "R-HSA-9028731", "R-MMU-9603381", "R-MMU-177929", "R-HSA-216083", "R-RNO-9034793", "R-HSA-428542", "R-MMU-6794361", "R-MMU-428890", "R-MMU-8985586", "R-HSA-9032500", "R-MMU-375281", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-RNO-1971475", "R-BTA-2022923", "R-MMU-1971475", "R-BTA-2022857", "R-MMU-9026527"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-DRE-2022854:r:Keratan sulfate biosynthesis", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-HSA-418555:r:G alpha (s) signalling events", "R-GGA-2022857:r:Keratan sulfate degradation", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-2022857:r:Keratan sulfate degradation", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-MMU-216083:r:Integrin cell surface interactions", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-2024101:r:CS/DS degradation", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-2022870:r:CS-GAG biosynthesis", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-CEL-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-2022857:r:Keratan sulfate degradation", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-DME-376176:r:Signaling by ROBO receptors", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-376176:r:Signaling by ROBO receptors", "R-DME-6798695:r:Neutrophil degranulation", "R-XTR-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-193634:r:Axonal growth 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proteoglycans", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-CFA-2024101:r:CS/DS degradation", "R-HSA-177929:r:Signaling by EGFR", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-2024101:r:CS/DS degradation", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-375281:r:Hormone ligand-binding receptors", "R-GGA-216083:r:Integrin cell surface interactions", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-375281:r:Hormone ligand-binding receptors", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-9673221:r:Defective F9 activation", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-GGA-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-6794361:r:Neurexins and neuroligins", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-CFA-2022923:r:DS-GAG biosynthesis", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-CEL-209968:r:Thyroxine biosynthesis", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-6794361:r:Neurexins and neuroligins", "R-GGA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-2024101:r:CS/DS degradation", "R-CFA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-BTA-2024101:r:CS/DS degradation", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-177929:r:Signaling by EGFR", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-6794361:r:Neurexins and neuroligins", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-375281:r:Hormone ligand-binding receptors", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-BTA-2022857:r:Keratan sulfate degradation", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1"], "type": "Domain"}, "IPR000375": {"description": "Dynamin stalk domain", "go_ids": [], "go_terms": [], "name": "Dynamin_stalk", "pathway_ids": ["R-MMU-8856828", "R-DDI-169911", "R-DME-190873", "R-BTA-196025", "R-HSA-8856828", "R-HSA-166016", "R-CEL-432722", "R-HSA-9766229", "R-BTA-190873", "R-BTA-75153", "R-RNO-196025", "R-SSC-1169408", "R-DME-3928665", "R-HSA-203641", "R-RNO-432722", "R-SPO-169911", "R-MMU-196025", "R-DME-437239", "R-RNO-432720", "R-MMU-166016", "R-HSA-432720", "R-DME-196025", "R-HSA-437239", "R-BTA-166016", "R-CFA-1169408", "R-HSA-909733", "R-SPO-190873", "R-HSA-9031628", "R-BTA-1169408", "R-SPO-196025", "R-MMU-9766229", "R-HSA-2132295", "R-SCE-169911", "R-DME-432720", "R-HSA-190873", "R-CEL-432720", "R-RNO-1169408", "R-MMU-432722", "R-CEL-190873", "R-CEL-437239", "R-MMU-203641", "R-HSA-1169408", "R-RNO-75153", "R-MMU-190873", "R-RNO-190873", "R-MMU-2132295", "R-DME-8856828", "R-BTA-437239", "R-RNO-8856828", "R-RNO-203641", "R-MMU-432720", "R-HSA-75153", "R-HSA-432722", "R-BTA-2132295", "R-DRE-75153", "R-HSA-196025", "R-BTA-8856828", "R-SCE-75153", "R-CEL-8856828", "R-RNO-2132295", "R-MMU-437239", "R-RNO-437239", "R-CEL-196025", "R-DME-432722", "R-DDI-75153", "R-MMU-1169408", "R-MMU-75153", "R-CEL-3928665", "R-HSA-177504", "R-CEL-75153", "R-CEL-1169408", "R-HSA-3928665", "R-RNO-9766229", "R-RNO-166016", "R-SPO-75153", "R-PFA-75153"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DDI-169911:r:Regulation of Apoptosis", "R-DME-190873:r:Gap junction degradation", "R-BTA-196025:r:Formation of annular gap junctions", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-190873:r:Gap junction degradation", "R-BTA-75153:r:Apoptotic execution phase", "R-RNO-196025:r:Formation of annular gap junctions", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-169911:r:Regulation of Apoptosis", "R-MMU-196025:r:Formation of annular gap junctions", "R-DME-437239:r:Recycling pathway of L1", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-196025:r:Formation of annular gap junctions", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CFA-1169408:r:ISG15 antiviral mechanism", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SPO-190873:r:Gap junction degradation", "R-HSA-9031628:r:NGF-stimulated transcription", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-SPO-196025:r:Formation of annular gap junctions", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SCE-169911:r:Regulation of Apoptosis", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-190873:r:Gap junction degradation", "R-CEL-437239:r:Recycling pathway of L1", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-RNO-75153:r:Apoptotic execution phase", "R-MMU-190873:r:Gap junction degradation", "R-RNO-190873:r:Gap junction degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-75153:r:Apoptotic execution phase", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-DRE-75153:r:Apoptotic execution phase", "R-HSA-196025:r:Formation of annular gap junctions", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-SCE-75153:r:Apoptotic execution phase", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-CEL-196025:r:Formation of annular gap junctions", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-75153:r:Apoptotic execution phase", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-75153:r:Apoptotic execution phase", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-CEL-75153:r:Apoptotic execution phase", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9766229:r:Degradation of CDH1", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-SPO-75153:r:Apoptotic execution phase", "R-PFA-75153:r:Apoptotic execution phase"], "type": "Domain"}, "IPR000380": {"description": "DNA topoisomerase, type IA", "go_ids": ["GO:0003677", "GO:0003917", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003917:DNA topoisomerase type I (single strand cut, ATP-independent) activity:F", "GO:0006265:DNA topological change:P"], "name": "Topo_IA", "pathway_ids": ["R-DDI-5693616", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-DDI-5693607", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Family"}, "IPR000382": {"description": "Peptidase S39B, luteovirus", "go_ids": ["GO:0016032", "GO:0016020", "GO:0004252"], "go_terms": ["GO:0016032:viral process:P", "GO:0016020:membrane:C", "GO:0004252:serine-type endopeptidase activity:F"], "name": "Peptidase_S39B_luteovirus", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR000383": {"description": "Xaa-Pro dipeptidyl-peptidase-like domain", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Xaa-Pro-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000389": {"description": "Small hydrophilic plant seed protein", "go_ids": [], "go_terms": [], "name": "Small_hydrophilic_seed_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000390": {"description": "Small drug/metabolite transporter protein family", "go_ids": ["GO:0016020", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0022857:transmembrane transporter activity:F"], "name": "Small_drug/metabolite_transptr", "pathway_ids": ["R-HSA-9913143"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance"], "type": "Family"}, "IPR000391": {"description": "Ring-hydroxylating dioxygenase beta subunit", "go_ids": [], "go_terms": [], "name": "Rng_hydr_dOase-bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000392": {"description": "NifH/frxC family", "go_ids": ["GO:0005524", "GO:0016491"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "NifH/frxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000394": {"description": "RNA polymerase sigma factor 54", "go_ids": ["GO:0016987", "GO:0001216"], "go_terms": ["GO:0016987:sigma factor activity:F", "GO:0001216:DNA-binding transcription activator activity:F"], "name": "RNA_pol_sigma_54", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000395": {"description": "Botulinum/Tetanus toxin, catalytic chain", "go_ids": ["GO:0006508", "GO:0008270", "GO:0004222"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008270:zinc ion binding:F", "GO:0004222:metalloendopeptidase activity:F"], "name": "Bot/tetX_LC", "pathway_ids": ["R-HSA-5250989", "R-HSA-5250968", "R-HSA-5250971", "R-HSA-5250982", "R-HSA-5250992", "R-HSA-5250955", "R-HSA-5250981", "R-HSA-5250958"], "pathways": ["R-HSA-5250989:r:Toxicity of botulinum toxin type G (botG)", "R-HSA-5250968:r:Toxicity of botulinum toxin type A (botA)", "R-HSA-5250971:r:Toxicity of botulinum toxin type C (botC)", "R-HSA-5250982:r:Toxicity of tetanus toxin (tetX)", "R-HSA-5250992:r:Toxicity of botulinum toxin type E (botE)", "R-HSA-5250955:r:Toxicity of botulinum toxin type D (botD)", "R-HSA-5250981:r:Toxicity of botulinum toxin type F (botF)", "R-HSA-5250958:r:Toxicity of botulinum toxin type B (botB)"], "type": "Domain"}, "IPR000396": {"description": "Cyclic-AMP phosphodiesterase, class-II", "go_ids": ["GO:0004115", "GO:0006198"], "go_terms": ["GO:0004115:3',5'-cyclic-AMP phosphodiesterase activity:F", "GO:0006198:cAMP catabolic process:P"], "name": "Pdiesterase2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000397": {"description": "Heat shock protein Hsp33", "go_ids": ["GO:0005737", "GO:0006457"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006457:protein folding:P"], "name": "Heat_shock_Hsp33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000398": {"description": "Thymidylate synthase", "go_ids": ["GO:0006231", "GO:0004799"], "go_terms": ["GO:0006231:dTMP biosynthetic process:P", "GO:0004799:thymidylate synthase activity:F"], "name": "Thymidylate_synthase", "pathway_ids": ["PWY-7198", "PWY-7199", "PWY-7184", "PWY-7187", "PWY-7210", "PWY-3841", "R-SCE-499943", "R-DME-499943", "R-SPO-499943", "R-HSA-69205", "R-HSA-499943", "R-RNO-499943", "R-MMU-499943"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-7199:t:pyrimidine deoxyribonucleosides salvage", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-3841:t:folate transformations II (plants)", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR000400": {"description": "Glycoside hydrolase, family 46", "go_ids": ["GO:0005576", "GO:0005975", "GO:0016977"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0005975:carbohydrate metabolic process:P", "GO:0016977:chitosanase activity:F"], "name": "Glyco_hydro_46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000402": {"description": "Sodium/potassium-transporting ATPase subunit beta", "go_ids": ["GO:0006813", "GO:0006814", "GO:0005890"], "go_terms": ["GO:0006813:potassium ion transport:P", "GO:0006814:sodium ion transport:P", "GO:0005890:sodium:potassium-exchanging ATPase complex:C"], "name": "Na/K_ATPase_sub_beta", "pathway_ids": ["R-MMU-2173795", "R-CEL-2173795", "R-CEL-210991", "R-RNO-210991", "R-DME-210991", "R-MMU-210991", "R-RNO-5578775", "R-SSC-2173795", "R-MMU-5578775", "R-HSA-936837", "R-HSA-9679191", "R-DME-2173795", "R-SSC-5578775", "R-BTA-936837", "R-RNO-936837", "R-CEL-936837", "R-SSC-936837", "R-CFA-936837", "R-RNO-2173795", "R-HSA-2173795", "R-BTA-5578775", "R-HSA-5578775", "R-GGA-2173795", "R-BTA-2173795", "R-MMU-936837", "R-HSA-210991"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-210991:r:Basigin interactions", "R-RNO-210991:r:Basigin interactions", "R-DME-210991:r:Basigin interactions", "R-MMU-210991:r:Basigin interactions", "R-RNO-5578775:r:Ion homeostasis", "R-SSC-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-5578775:r:Ion homeostasis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-SSC-936837:r:Ion transport by P-type ATPases", "R-CFA-936837:r:Ion transport by P-type ATPases", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-HSA-210991:r:Basigin interactions"], "type": "Family"}, "IPR000403": {"description": "Phosphatidylinositol 3-/4-kinase, catalytic domain", "go_ids": [], "go_terms": [], "name": "PI3/4_kinase_cat_dom", "pathway_ids": ["R-HSA-9842640", "R-MMU-1250342", "R-MMU-8856828", "R-DDI-114604", "R-BTA-198203", "R-MMU-6811558", "R-MMU-5654720", "R-BTA-5673001", "R-MMU-1632852", "R-HSA-912631", "R-BTA-8851907", "R-GGA-351433", "R-MMU-6804756", "R-SPO-1660499", "R-RNO-512988", "R-MMU-5685938", "R-RNO-5218920", "R-BTA-5654710", "R-RNO-912631", "R-HSA-5654695", "R-MMU-69473", "R-MMU-201556", "R-BTA-4420097", "R-BTA-6811558", "R-SCE-1660517", "R-CEL-9639288", "R-DME-9664873", "R-HSA-512988", "R-RNO-416476", "R-MMU-186763", "R-RNO-165159", "R-HSA-3270619", "R-MMU-8866654", "R-HSA-168138", 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"R-HSA-5693571", "R-HSA-975957", "R-CEL-5654689", "R-RNO-5654695", "R-RNO-1660499", "R-BTA-109704", "R-HSA-912526", "R-BTA-9013404", "R-HSA-201556", "R-BTA-1257604", "R-HSA-3371571", "R-DME-6803207", "R-CEL-9009391", "R-HSA-9856530", "R-BTA-9607240", "R-MMU-5654689", "R-MMU-9013149", "R-HSA-5693579", "R-CEL-1250342", "R-CEL-166208", "R-DME-9856530", "R-BTA-389357", "R-SCE-5218920", "R-CEL-9856530", "R-MMU-9607240", "R-RNO-5654710", "R-DRE-201722", "R-CEL-912631", "R-MMU-9639288", "R-RNO-9013149", "R-MMU-9013404", "R-MMU-5693616", "R-MMU-69541", "R-HSA-4420097", "R-RNO-112399", "R-HSA-9709570", "R-RNO-2029485", "R-RNO-202424", "R-MMU-5668599", "R-MMU-1660514", "R-SCE-9664873", "R-MMU-5628897", "R-MMU-5693568", "R-DDI-1660517", "R-HSA-9664565", "R-HSA-5655302", "R-SCE-9856530", "R-RNO-389357", "R-RNO-201556", "R-DME-5693607", "R-RNO-8853659", "R-DME-69473", "R-MMU-8853659", "R-HSA-2219530", "R-DDI-380972", "R-BTA-912631", "R-BTA-416476", "R-HSA-9013404", "R-HSA-9013149", "R-RNO-1660517", "R-HSA-9703648", "R-HSA-5654720", "R-RNO-380972", "R-HSA-9704331", "R-BTA-114604", "R-HSA-5693554", "R-HSA-5693548", "R-HSA-2559586", "R-HSA-198203", "R-HSA-9679504", "R-RNO-4420097", "R-DME-380972", "R-DME-5628897", "R-RNO-8943724", "R-HSA-349425", "R-MMU-432722", "R-CEL-1632852", "R-SCE-2559586", "R-CEL-201722", "R-HSA-416476", "R-HSA-1250342", "R-HSA-5628897", "R-CEL-9013149", "R-SCE-5693565", "R-CEL-8943724", "R-HSA-1236382", "R-SCE-1257604", "R-DDI-5693607", "R-HSA-9920951", "R-SPO-1257604", "R-DRE-5689880", "R-BTA-1250342", "R-DRE-975957", "R-MMU-983695", "R-RNO-180292", "R-HSA-1433557", "R-MMU-5685942", "R-MMU-112399", "R-RNO-114604", "R-HSA-9703465", "R-BTA-2730905", "R-SPO-2559586", "R-RNO-1483248", "R-CEL-1963642", "R-HSA-6803204", "R-RNO-5654720", "R-CEL-1660499", "R-MMU-2424491", "R-DDI-389357", "R-MMU-166208", "R-SPO-5693548", "R-DME-5693548", "R-SCE-5668599", "R-RNO-186763"], "pathways": ["R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-BTA-198203:r:PI3K/AKT activation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-MMU-1632852:r:Macroautophagy", "R-HSA-912631:r:Regulation of signaling by CBL", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-912631:r:Regulation of signaling by CBL", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-201556:r:Signaling by ALK", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-DME-9664873:r:Pexophagy", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-186763:r:Downstream signal transduction", "R-RNO-165159:r:MTOR signalling", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-1632852:r:Macroautophagy", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-5693548:r:Sensing of DNA Double Strand Breaks", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-165159:r:MTOR signalling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-166208:r:mTORC1-mediated signalling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-166208:r:mTORC1-mediated signalling", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-XTR-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-912446:r:Meiotic recombination", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-112399:r:IRS-mediated signalling", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-180292:r:GAB1 signalosome", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-109704:r:PI3K Cascade", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-XTR-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DDI-9664873:r:Pexophagy", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-3214847:r:HATs acetylate histones", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-MMU-416476:r:G alpha (q) 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"R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-2424491:r:DAP12 signaling", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-186763:r:Downstream signal transduction"], "type": "Domain"}, "IPR000404": {"description": "Flavivirus non-structural protein NS4A", "go_ids": ["GO:0016032", "GO:0016070", "GO:0044423"], "go_terms": ["GO:0016032:viral process:P", "GO:0016070:RNA metabolic process:P", "GO:0044423:virion component:C"], "name": "Flavi_NS4A", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR000406": {"description": "Rho protein GDP-dissociation inhibitor", "go_ids": ["GO:0005094", "GO:0005737", "GO:0007266", "GO:0005515"], "go_terms": ["GO:0005094:Rho GDP-dissociation inhibitor activity:F", "GO:0005737:cytoplasm:C", "GO:0007266:Rho protein signal transduction:P", "GO:0005515:protein binding:F"], "name": "Rho_GDI", "pathway_ids": ["R-SCE-9013423", "R-CEL-8980692", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-9013106", "R-MMU-9013148", "R-MMU-9013404", "R-BTA-9013148", "R-DDI-9013149", "R-CEL-9013149", "R-SPO-9013106", "R-HSA-9013423", "R-CEL-9013407", "R-SCE-8980692", "R-SCE-9013149", "R-HSA-9013148", "R-RNO-9013404", "R-RNO-9013106", "R-HSA-9013408", "R-RNO-9013408", "R-DDI-9013423", "R-CEL-9013148", "R-MMU-193634", "R-CEL-9013423", "R-BTA-9013407", "R-MMU-9013407", "R-RNO-9013407", "R-RNO-9013148", "R-SPO-9013148", "R-RNO-193634", "R-MMU-209563", "R-RNO-209563", "R-SCE-9013106", "R-HSA-209563", "R-SPO-8980692", "R-HSA-9013404", "R-HSA-9013149", "R-BTA-9013408", "R-HSA-193634", "R-HSA-8980692", "R-SCE-9013148", "R-MMU-9013423", "R-MMU-9013026", "R-HSA-9013026", "R-DDI-9013404", "R-MMU-9013149", "R-HSA-9013407"], "pathways": ["R-SCE-9013423:r:RAC3 GTPase cycle", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-209563:r:Axonal growth stimulation", "R-RNO-209563:r:Axonal growth stimulation", "R-SCE-9013106:r:RHOC GTPase cycle", "R-HSA-209563:r:Axonal growth stimulation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR000407": {"description": "Nucleoside phosphatase GDA1/CD39", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "GDA1_CD39_NTPase", "pathway_ids": ["R-CEL-8850843", "R-SCE-8850843", "R-SPO-8850843", "R-HSA-9660826", "R-HSA-8850843", "R-RNO-8850843", "R-XTR-8850843", "R-MMU-8850843"], "pathways": ["R-CEL-8850843:r:Phosphate bond hydrolysis by NTPDase proteins", "R-SCE-8850843:r:Phosphate bond hydrolysis by NTPDase proteins", "R-SPO-8850843:r:Phosphate bond hydrolysis by NTPDase proteins", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-8850843:r:Phosphate bond hydrolysis by NTPDase proteins", "R-RNO-8850843:r:Phosphate bond hydrolysis by NTPDase proteins", "R-XTR-8850843:r:Phosphate bond hydrolysis by NTPDase proteins", "R-MMU-8850843:r:Phosphate bond hydrolysis by NTPDase proteins"], "type": "Family"}, "IPR000408": {"description": "Regulator of chromosome condensation, RCC1", "go_ids": [], "go_terms": [], "name": "Reg_chr_condens", "pathway_ids": ["R-SCE-9615933", "R-DDI-354192", "R-HSA-9833482", "R-MMU-2467813", "R-RNO-9013149", "R-HSA-5693565", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-MMU-9615933", "R-MMU-69473", "R-HSA-6793080", "R-CEL-9909505", "R-HSA-5693607", "R-HSA-2980767", "R-DDI-9013423", "R-DRE-5663220", "R-HSA-9629569", "R-DDI-193648", "R-DME-9013149", "R-MMU-141444", "R-HSA-69473", "R-DDI-5673001", "R-CEL-9833482", "R-HSA-141444", "R-HSA-8876198", "R-HSA-9648025", "R-DME-9615933", "R-HSA-3301854", "R-HSA-9013149", "R-HSA-9615933", "R-MMU-8876198", "R-MMU-3108214", "R-RNO-983168", "R-MMU-5693571", "R-MMU-5663220", "R-DME-983168", "R-HSA-2467813", "R-HSA-3108214", "R-HSA-168928", "R-MMU-2980767", "R-RNO-8876198", "R-SPO-9615933", "R-HSA-936440", "R-HSA-1169408", "R-CEL-983168", "R-DDI-9013149", "R-HSA-9909505", "R-MMU-5693565", "R-DDI-381676", "R-CEL-936440", "R-HSA-68877", "R-HSA-165054", "R-HSA-9833110", "R-SCE-983168", "R-MMU-9648025", "R-DDI-1169408", "R-MMU-5693607", "R-DDI-9833482", "R-MMU-2500257", "R-HSA-9937008", "R-DDI-171007", "R-HSA-2500257", "R-DDI-936440", "R-DME-8876198", "R-DRE-2500257", "R-DDI-392517", "R-HSA-983168", "R-CEL-9615933", "R-DDI-983168", "R-HSA-5693571", "R-MMU-9629569", "R-CEL-1169408", "R-DDI-9909505", "R-MMU-983168", "R-HSA-5663220", "R-HSA-180746", "R-MMU-9013149", "R-DDI-1169092"], "pathways": ["R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DDI-354192:r:Integrin signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-CEL-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-9629569:r:Protein hydroxylation", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-9833110:r:RSV-host interactions", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-DDI-171007:r:p38MAPK events", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-392517:r:Rap1 signalling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-9629569:r:Protein hydroxylation", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DDI-1169092:r:Activation of RAS in B cells"], "type": "Repeat"}, "IPR000409": {"description": "BEACH domain", "go_ids": [], "go_terms": [], "name": "BEACH_dom", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-DRE-9013148", "R-DRE-6798695", "R-HSA-5626978", "R-HSA-9013148", "R-HSA-2122947", "R-MMU-6798695", "R-MMU-5626978", "R-HSA-112314", "R-HSA-9609736", "R-HSA-163615"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-163615:r:PKA activation"], "type": "Domain"}, "IPR000412": {"description": "ABC-2 transporter", "go_ids": ["GO:0055085", "GO:0016020", "GO:0043190", "GO:0140359"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0016020:membrane:C", "GO:0043190:ATP-binding cassette (ABC) transporter complex:C", "GO:0140359:ABC-type transporter activity:F"], "name": "ABC_2_transport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000415": {"description": "Nitroreductase-like", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Nitroreductase-like", "pathway_ids": ["R-HSA-209968", "R-MMU-209968", "R-RNO-209968", "R-DME-209968", "R-DRE-209968", "R-CEL-209968"], "pathways": ["R-HSA-209968:r:Thyroxine biosynthesis", "R-MMU-209968:r:Thyroxine biosynthesis", "R-RNO-209968:r:Thyroxine biosynthesis", "R-DME-209968:r:Thyroxine biosynthesis", "R-DRE-209968:r:Thyroxine biosynthesis", "R-CEL-209968:r:Thyroxine biosynthesis"], "type": "Homologous_superfamily"}, "IPR000416": {"description": "Haemagglutinin outer capsid protein VP4, concanavalin-like domain", "go_ids": ["GO:0019028", "GO:0019058"], "go_terms": ["GO:0019028:viral capsid:C", "GO:0019058:viral life cycle:P"], "name": "VP4_concanavalin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000417": {"description": "Hydroxyethylthiazole kinase", "go_ids": ["GO:0004417", "GO:0009228", "GO:0000287", "GO:0005524"], "go_terms": ["GO:0004417:hydroxyethylthiazole kinase activity:F", "GO:0009228:thiamine biosynthetic process:P", "GO:0000287:magnesium ion binding:F", "GO:0005524:ATP binding:F"], "name": "Hyethyz_kinase", "pathway_ids": ["PWY-6897", "PWY-7356", "PWY-7357", "PWY-8457"], "pathways": ["PWY-6897:t:thiamine diphosphate salvage II", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "PWY-7357:t:thiamine diphosphate formation from pyrithiamine and oxythiamine (yeast)", "PWY-8457:t:thiamine diphosphate salvage V"], "type": "Family"}, "IPR000418": {"description": "Ets domain", "go_ids": ["GO:0003700", "GO:0006355", "GO:0043565"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0043565:sequence-specific DNA binding:F"], "name": "Ets_dom", "pathway_ids": ["R-DME-8939245", "R-HSA-198753", "R-HSA-8939247", "R-HSA-2151201", "R-BTA-2559585", "R-HSA-2559585", "R-DME-8939247", "R-CEL-2559585", "R-MMU-8939247", "R-HSA-9609690", "R-HSA-9634638", "R-HSA-9673768", "R-DME-2559585", "R-MMU-2151201", "R-RNO-1912408", "R-BTA-8939247", "R-HSA-1912408", "R-DME-5687128", "R-HSA-9703465", "R-MMU-8939245", "R-DME-2151201", "R-HSA-8939245", "R-GGA-2559585", "R-HSA-5687128", "R-MMU-1912408", "R-HSA-9927418", "R-HSA-9616222", "R-HSA-9031628", "R-MMU-5687128", "R-HSA-8939236", "R-MMU-2559585", "R-HSA-9927426", "R-RNO-2559585"], "pathways": ["R-DME-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-198753:r:ERK/MAPK targets", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-DME-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-CEL-2559585:r:Oncogene Induced Senescence", "R-MMU-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-DME-2559585:r:Oncogene Induced Senescence", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-1912408:r:Pre-NOTCH Transcription and Translation", "R-BTA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-GGA-2559585:r:Oncogene Induced Senescence", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9031628:r:NGF-stimulated transcription", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-RNO-2559585:r:Oncogene Induced Senescence"], "type": "Domain"}, "IPR000420": {"description": "Cell wall mannoprotein PIR repeat", "go_ids": ["GO:0005618", "GO:0005199"], "go_terms": ["GO:0005618:cell wall:C", "GO:0005199:structural constituent of cell wall:F"], "name": "Yeast_PIR_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR000421": {"description": "Coagulation factor 5/8, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FA58C", "pathway_ids": ["R-MMU-204005", "R-HSA-399956", "R-HSA-9672383", "R-DRE-399954", "R-HSA-9672396", "R-HSA-9674519", "R-MMU-5694530", "R-HSA-140837", "R-HSA-9672397", "R-HSA-977225", "R-HSA-9673202", "R-DRE-194306", "R-MMU-399956", "R-MMU-8957275", "R-HSA-5694530", "R-RNO-399954", "R-HSA-114608", "R-MMU-3000171", "R-RNO-8957275", "R-MMU-381426", "R-HSA-9926550", "R-HSA-9672387", "R-HSA-399955", "R-HSA-9672391", "R-MMU-399954", "R-HSA-447038", "R-HSA-381426", "R-MMU-5620924", "R-HSA-9672395", "R-HSA-9672393", "R-RNO-3000171", "R-HSA-447043", "R-RNO-399956", "R-HSA-5620924", "R-RNO-445144", "R-HSA-5083635", "R-MMU-399955", "R-HSA-376176", "R-MMU-163841", "R-MMU-140837", "R-HSA-3000171", "R-HSA-9694614", "R-MMU-445144", "R-HSA-140875", "R-HSA-163841", "R-HSA-194306", "R-HSA-447041", "R-MMU-140875", "R-HSA-204005", "R-RNO-381426", "R-RNO-5173214", "R-HSA-5173214", "R-RNO-399955", "R-HSA-399954", "R-DRE-399956", "R-MMU-5173214", "R-HSA-445144", "R-HSA-8957275", "R-MMU-194306", "R-RNO-194306", "R-CEL-3000171", "R-HSA-9927426", "R-MMU-114608"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-9672383:r:Defective factor IX causes thrombophilia", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-HSA-9674519:r:Defective F8 sulfation at Y1699", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9672397:r:Defective F8 secretion", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-9673202:r:Defective F9 variant does not activate FX", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-114608:r:Platelet degranulation", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-9672387:r:Defective F8 accelerates dissociation of the A2 domain", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-447038:r:NrCAM interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-9672395:r:Defective F8 binding to the cell membrane", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-447043:r:Neurofascin interactions", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-445144:r:Signal transduction by L1", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-376176:r:Signaling by ROBO receptors", "R-MMU-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9694614:r:Attachment and Entry", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-447041:r:CHL1 interactions", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR000422": {"description": "3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB", "go_ids": ["GO:0008686", "GO:0009231"], "go_terms": ["GO:0008686:3,4-dihydroxy-2-butanone-4-phosphate synthase activity:F", "GO:0009231:riboflavin biosynthetic process:P"], "name": "DHBP_synthase_RibB", "pathway_ids": ["PWY-6168", "PWY-6167"], "pathways": ["PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Family"}, "IPR000424": {"description": "Primosome PriB/single-strand DNA-binding", "go_ids": ["GO:0003697"], "go_terms": ["GO:0003697:single-stranded DNA binding:F"], "name": "Primosome_PriB/ssb", "pathway_ids": ["R-DRE-9837999", "R-CEL-9913635", "R-MMU-9837999", "R-HSA-2151201", "R-CEL-9837999", "R-MMU-9913635", "R-SPO-9837999", "R-SCE-9837999", "R-DME-9837999", "R-DME-9913635", "R-RNO-9913635", "R-HSA-9837999", "R-DRE-9913635", "R-RNO-9837999", "R-HSA-9913635"], "pathways": ["R-DRE-9837999:r:Mitochondrial protein degradation", "R-CEL-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-RNO-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DRE-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Family"}, "IPR000425": {"description": "Major intrinsic protein", "go_ids": ["GO:0016020", "GO:0015267", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0015267:channel activity:F", "GO:0055085:transmembrane transport:P"], "name": "MIP", "pathway_ids": ["R-CFA-432047", "R-HSA-1247673", "R-RNO-1237044", "R-RNO-1247673", "R-HSA-9725554", "R-HSA-9925561", "R-DME-432047", "R-DME-1237044", "R-HSA-432030", "R-HSA-1237044", "R-BTA-1247673", "R-DDI-1237044", "R-PFA-432040", "R-RNO-432047", "R-HSA-432040", "R-CFA-432040", "R-SPO-432047", "R-SPO-432030", "R-DDI-432047", "R-CFA-1237044", "R-DME-432040", "R-HSA-9925563", "R-HSA-3299685", "R-MMU-1237044", "R-DDI-1247673", "R-DME-1247673", "R-SPO-432040", "R-MMU-1247673", "R-SSC-432047", "R-DDI-432040", "R-SCE-432040", "R-BTA-432047", "R-GGA-432047", "R-MMU-432040", "R-MMU-432047", "R-SCE-432030", "R-RNO-432030", "R-BTA-432040", "R-PFA-432047", "R-PFA-432030", "R-HSA-432047", "R-RNO-432040", "R-BTA-1237044", "R-MMU-432030", "R-CFA-1247673", "R-SCE-432047"], "pathways": ["R-CFA-432047:r:Passive transport by Aquaporins", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-DME-432047:r:Passive transport by Aquaporins", "R-DME-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-432030:r:Transport of glycerol from adipocytes to the liver by Aquaporins", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-BTA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-DDI-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-PFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-432047:r:Passive transport by Aquaporins", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-SPO-432047:r:Passive transport by Aquaporins", "R-SPO-432030:r:Transport of glycerol from adipocytes to the liver by Aquaporins", "R-DDI-432047:r:Passive transport by Aquaporins", "R-CFA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DME-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DDI-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-DME-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-SPO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-SSC-432047:r:Passive transport by Aquaporins", "R-DDI-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-SCE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-432047:r:Passive transport by Aquaporins", "R-GGA-432047:r:Passive transport by Aquaporins", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-432047:r:Passive transport by Aquaporins", "R-SCE-432030:r:Transport of glycerol from adipocytes to the liver by Aquaporins", "R-RNO-432030:r:Transport of glycerol from adipocytes to the liver by Aquaporins", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-PFA-432047:r:Passive transport by Aquaporins", "R-PFA-432030:r:Transport of glycerol from adipocytes to the liver by Aquaporins", "R-HSA-432047:r:Passive transport by Aquaporins", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-432030:r:Transport of glycerol from adipocytes to the liver by Aquaporins", "R-CFA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-SCE-432047:r:Passive transport by Aquaporins"], "type": "Family"}, "IPR000426": {"description": "Proteasome alpha-subunit, N-terminal domain", "go_ids": ["GO:0006511", "GO:0019773"], "go_terms": ["GO:0006511:ubiquitin-dependent protein catabolic process:P", "GO:0019773:proteasome core complex, alpha-subunit complex:C"], "name": "Proteasome_asu_N", "pathway_ids": ["R-HSA-174178", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-HSA-8951664", "R-BTA-9755511", "R-HSA-9010553", "R-HSA-75815", "R-CEL-8941858", "R-MMU-8948751", "R-DME-8948751", "R-SPO-5689880", "R-MMU-5689880", "R-CEL-1234176", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-DME-5676590", "R-RNO-8854050", "R-DME-9912633", "R-HSA-450408", "R-RNO-450408", "R-SCE-5689880", "R-HSA-211733", "R-DDI-6798695", "R-DME-4641257", "R-HSA-5607761", "R-DME-432524", "R-DDI-174084", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-SPO-9912633", "R-DDI-4641258", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-CEL-8948751", "R-MMU-9766229", "R-RNO-69481", "R-HSA-174154", "R-DDI-187577", "R-BTA-349425", "R-RNO-1234176", "R-RNO-5632684", "R-DME-202424", "R-MMU-187577", "R-DME-187577", "R-RNO-9932298", "R-DDI-382556", "R-BTA-1236978", "R-RNO-174178", "R-HSA-9824272", "R-MMU-174178", "R-BTA-4608870", "R-BTA-5676590", "R-MMU-349425", "R-CEL-8854050", "R-HSA-9907900", "R-DME-174084", "R-DME-350562", "R-BTA-2871837", "R-BTA-174154", "R-DDI-69601", "R-DME-9929491", "R-SCE-1236974", "R-HSA-9762114", "R-DDI-5689880", "R-HSA-195253", "R-BTA-187577", "R-CEL-9755511", "R-DME-6798695", "R-RNO-9755511", "R-DME-8939236", "R-DME-174184", "R-RNO-174113", "R-BTA-9929356", "R-MMU-5676590", "R-MMU-174184", "R-RNO-187577", "R-RNO-68867", "R-RNO-350562", "R-DME-9932298", "R-RNO-9762114", "R-BTA-9954709", "R-DME-9020702", "R-RNO-69017", "R-CEL-9762114", "R-DME-5689880", "R-HSA-5358346", "R-SPO-350562", "R-CEL-8951664", "R-HSA-6798695", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-BTA-5610785", "R-BTA-202424", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-BTA-6798695", "R-RNO-9912633", "R-DDI-1236974", "R-DDI-8951664", "R-DDI-1236978", "R-MMU-8951664", "R-DME-8939902", "R-CEL-5689603", "R-CEL-382556", "R-RNO-174154", "R-MMU-9929356", "R-HSA-9912633", "R-DME-4608870", "R-SCE-5668541", "R-DME-1236974", "R-RNO-9929356", "R-BTA-9912633", "R-HSA-69481", "R-DME-9762114", "R-BTA-174084", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-HSA-4641258", "R-SPO-5689603", "R-RNO-8939236", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-BTA-4641258", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-RNO-2467813", "R-DME-5607764", "R-BTA-1236974", "R-DME-209406", "R-DME-2871837", "R-DME-8941858", "R-MMU-5610780", "R-SPO-6798695", "R-DME-9954709", "R-BTA-382556", "R-SCE-9912633", "R-CEL-8939902", "R-MMU-9755511", "R-RNO-1236974", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-HSA-5362768", "R-DME-5689603", "R-DDI-9954709", "R-DME-216167", "R-MMU-5658442", "R-RNO-8852276", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-RNO-9907900", "R-BTA-8948751", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-RNO-8941858", "R-RNO-5607764", "R-HSA-69017", "R-RNO-1169091", "R-BTA-9020702", "R-RNO-9766229", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-HSA-202424", "R-CEL-4641257", "R-DDI-174154", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-MMU-174154", "R-BTA-1234176", "R-MMU-69017", "R-CEL-195253", "R-MMU-9020702", "R-DME-5658442", "R-RNO-382556", "R-RNO-5687128", "R-MMU-69481", "R-BTA-350562", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-BTA-68867", "R-HSA-1234176", "R-RNO-4641258", "R-HSA-9931269", "R-MMU-68867", "R-HSA-9929491", "R-DME-209461", "R-DDI-9912633", "R-RNO-5689880", "R-DME-75815", "R-RNO-8951664", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-MMU-5687128", "R-RNO-5358346", "R-DME-5358346", "R-RNO-6798695", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-DME-9907900", "R-RNO-4641257", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-RNO-349425", "R-MMU-9762114", "R-BTA-174184", "R-MMU-195253", "R-MMU-202424", "R-MMU-382556", "R-HSA-5610780", "R-BTA-8939236", "R-DME-209360", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-DME-432626", "R-MMU-5607761", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-MMU-8939902", "R-DME-174178", "R-RNO-195253", "R-HSA-8939236", "R-DDI-8854050", "R-BTA-983168", "R-MMU-5607764", "R-DME-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577", "R-HSA-5676590", "R-DDI-5632684", "R-BTA-9929491", "R-CEL-9912633", "R-HSA-4641257", "R-RNO-202424", "R-MMU-9929491", "R-HSA-174113", "R-BTA-9932298", "R-BTA-9762114", "R-RNO-5607761", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-CEL-4641258", "R-DDI-5658442", "R-BTA-450408", "R-HSA-8941858", "R-HSA-9755511", "R-RNO-9931269", "R-CEL-9929491", "R-DME-9755511", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-RNO-174084", "R-HSA-5689603", "R-RNO-983168", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DME-1169091", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-BTA-8941858", "R-DME-4641258", "R-HSA-174184", "R-SPO-1236974", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-CEL-1236974", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-MMU-9912633", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-HSA-5687128", "R-DME-5632684", "R-DME-432395", "R-RNO-5658442", "R-MMU-1236974", "R-MMU-983168", "R-RNO-5610785", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-432524:r:Degradation of PER", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-SPO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SCE-1236974:r:ER-Phagosome pathway", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-1236974:r:ER-Phagosome pathway", "R-DDI-8951664:r:Neddylation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-1236974:r:ER-Phagosome pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-4641258:r:Degradation of DVL", "R-SPO-5689603:r:UCH proteinases", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-4641258:r:Degradation of DVL", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-1236974:r:ER-Phagosome pathway", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-SCE-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-1236974:r:ER-Phagosome pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DME-5689603:r:UCH proteinases", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-9907900:r:Proteasome assembly", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5689603:r:UCH proteinases", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-202424:r:Downstream TCR signaling", "R-CEL-4641257:r:Degradation of AXIN", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DDI-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-8951664:r:Neddylation", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome 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acetylation", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-DME-114608:r:Platelet degranulation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-3371568:r:Attenuation phase", "R-CEL-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9664873:r:Pexophagy", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-9664873:r:Pexophagy", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-3371568:r:Attenuation phase", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-9664873:r:Pexophagy", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-SPO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-9664873:r:Pexophagy", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-DME-9035034:r:RHOF GTPase cycle", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-72086:r:mRNA Capping", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-3371568:r:Attenuation phase", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-390522:r:Striated Muscle Contraction", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-390522:r:Striated Muscle Contraction", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR000435": {"description": "Tektins", "go_ids": ["GO:0060294"], "go_terms": ["GO:0060294:cilium movement involved in cell motility:P"], "name": "Tektins", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000436": {"description": "Sushi/SCR/CCP domain", "go_ids": [], "go_terms": [], "name": "Sushi_SCR_CCP_dom", "pathway_ids": ["R-RNO-2022923", "R-HSA-373080", "R-SSC-2168880", "R-RNO-9020558", "R-HSA-3000178", "R-HSA-3560783", "R-RNO-1474228", "R-SSC-202733", "R-MMU-166662", "R-CFA-114608", "R-HSA-209968", "R-BTA-8957275", "R-HSA-166665", "R-MMU-202733", "R-RNO-173623", "R-SSC-174577", "R-HSA-166663", "R-MMU-5673001", "R-BTA-977606", "R-HSA-1474228", "R-BTA-1971475", "R-SSC-2022854", "R-HSA-2022870", "R-SSC-2022857", "R-DME-114608", "R-HSA-1971475", "R-HSA-2022857", "R-HSA-8983432", "R-MMU-1296041", "R-HSA-419037", "R-MMU-173736", "R-RNO-2022857", "R-HSA-3656244", "R-MMU-912526", "R-GGA-2132285", "R-RNO-2855086", "R-HSA-2022923", "R-HSA-173736", "R-HSA-3656225", "R-MMU-209968", "R-MMU-2024101", "R-RNO-6798695", 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"R-RNO-997272", "R-RNO-198933", "R-RNO-2168880", "R-MMU-420499", "R-HSA-420499", "R-RNO-420499", "R-MMU-2022854", "R-HSA-5673001", "R-HSA-3560801", "R-RNO-381426", "R-SSC-173736", "R-MMU-198933", "R-HSA-2022854", "R-HSA-3656243", "R-HSA-4420332", "R-MMU-997272", "R-HSA-198933", "R-MMU-6798695", "R-DME-913709", "R-GGA-2132263", "R-MMU-114608", "R-MMU-2022870", "R-BTA-173736", "R-RNO-166662", "R-MMU-2855086", "R-BTA-3000178", "R-MMU-6807878", "R-MMU-3000480", "R-RNO-114608", "R-BTA-202733", "R-HSA-8877330", "R-HSA-977606", "R-RNO-8957275", "R-RNO-2024101", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-997272", "R-BTA-2024101", "R-RNO-209968", "R-RNO-977444", "R-HSA-6807878", "R-RNO-1296041", "R-SSC-977606", "R-RNO-1971475", "R-HSA-418594", "R-HSA-8957275", "R-BTA-2022923", "R-GGA-2132273", "R-MMU-1971475", "R-GGA-2132293"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-SSC-2168880:r:Scavenging of heme from plasma", "R-RNO-9020558:r:Interleukin-2 signaling", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-MMU-166662:r:Lectin pathway of complement activation", "R-CFA-114608:r:Platelet degranulation", "R-HSA-209968:r:Thyroxine biosynthesis", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-166665:r:Terminal pathway of complement", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-SSC-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-BTA-977606:r:Regulation of Complement cascade", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-SSC-2022857:r:Keratan sulfate degradation", "R-DME-114608:r:Platelet degranulation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-HSA-8983432:r:Interleukin-15 signaling", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-419037:r:NCAM1 interactions", "R-MMU-173736:r:Alternative complement activation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-GGA-2132285:r:Complement Cascade", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-173736:r:Alternative complement activation", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-MMU-209968:r:Thyroxine biosynthesis", "R-MMU-2024101:r:CS/DS degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-977068:r:Termination of O-glycan biosynthesis", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-HSA-977444:r:GABA B receptor activation", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-166665:r:Terminal pathway of complement", "R-HSA-373760:r:L1CAM interactions", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-HSA-9020558:r:Interleukin-2 signaling", "R-MMU-977606:r:Regulation of Complement cascade", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-RNO-166665:r:Terminal pathway of complement", "R-BTA-166663:r:Initial triggering of complement", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-HSA-166662:r:Lectin pathway of complement activation", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-MMU-977444:r:GABA B receptor activation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-166663:r:Initial triggering of complement", "R-GGA-2132281:r:Regulation of complement cascades", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-MMU-9020558:r:Interleukin-2 signaling", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-2024101:r:CS/DS degradation", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-MMU-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-173736:r:Alternative complement activation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-913709:r:O-linked glycosylation of mucins", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-MMU-114608:r:Platelet degranulation", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-BTA-173736:r:Alternative complement activation", "R-RNO-166662:r:Lectin pathway of complement activation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-BTA-3000178:r:ECM proteoglycans", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024101:r:CS/DS degradation", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-209968:r:Thyroxine biosynthesis", "R-RNO-977444:r:GABA B receptor activation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-SSC-977606:r:Regulation of Complement cascade", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-GGA-2132273:r:Formation of membrane-bound convertase C3", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-GGA-2132293:r:Formation of fluid-phase convertase C3"], "type": "Domain"}, "IPR000438": {"description": "Acetyl-CoA carboxylase carboxyl transferase, beta subunit", "go_ids": ["GO:0003989", "GO:0006633", "GO:0009317"], "go_terms": ["GO:0003989:acetyl-CoA carboxylase activity:F", "GO:0006633:fatty acid biosynthetic process:P", "GO:0009317:acetyl-CoA carboxylase complex:C"], "name": "Acetyl_CoA_COase_Trfase_b_su", "pathway_ids": ["PWY-5743", "PWY-5789", "PWY-6722", "PWY-4381", "PWY-5744"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-6722:t:candicidin biosynthesis", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "PWY-5744:t:glyoxylate assimilation"], "type": "Family"}, "IPR000439": {"description": "Large ribosomal subunit protein eL15", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL15", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-CFA-1799339", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-CFA-72706", "R-DDI-9954714", "R-CEL-72706", "R-CFA-9954709", "R-CEL-9954716", "R-CEL-9954714", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-BTA-156827", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CFA-6791226", "R-CEL-156827", "R-CFA-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-CEL-72689", "R-CFA-9954714", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-CFA-975957", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-CFA-72689", "R-SCE-72689", "R-MMU-975956", "R-CFA-9954716", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-CFA-975956", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-CFA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CFA-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CFA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000440": {"description": "NADH:ubiquinone/plastoquinone oxidoreductase, chain 3", "go_ids": ["GO:0008137"], "go_terms": ["GO:0008137:NADH dehydrogenase (ubiquinone) activity:F"], "name": "NADH_UbQ/plastoQ_OxRdtase_su3", "pathway_ids": ["R-HSA-5419276", "R-SSC-5419276", "R-HSA-6799198", "R-MMU-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DRE-611105", "R-SSC-6799198", "R-GGA-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-GGA-5419276", "R-RNO-5419276", "R-GGA-611105", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-DRE-5419276", "R-BTA-6799198", "R-SSC-611105", "R-BTA-611105"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-SSC-6799198:r:Complex I biogenesis", "R-GGA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-611105:r:Respiratory electron transport", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-5419276:r:Mitochondrial translation termination", "R-BTA-6799198:r:Complex I biogenesis", "R-SSC-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR000445": {"description": "Helix-hairpin-helix motif", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "HhH_motif", "pathway_ids": ["R-HSA-9630222", "R-HSA-110357", "R-HSA-9608287", "R-RNO-110331", "R-HSA-110328", "R-HSA-9608290", "R-RNO-110357", "R-MMU-110331", "R-CEL-110329", "R-BTA-110329", "R-MMU-110357", "R-HSA-110331", "R-BTA-110357", "R-SPO-110329", "R-MMU-110329", "R-HSA-110329", "R-HSA-110330", "R-CEL-110357", 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protein import", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-8949613:r:Cristae formation", "R-MMU-1268020:r:Mitochondrial protein import", "R-BTA-1268020:r:Mitochondrial protein import", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-1268020:r:Mitochondrial protein import", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR000456": {"description": "Large ribosomal subunit protein bL17", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bL17", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR000458": {"description": "Mucin-like glycoprotein", "go_ids": [], "go_terms": [], "name": "Tryp_mucin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000462": {"description": "CDP-alcohol phosphatidyltransferase", "go_ids": ["GO:0008654", "GO:0016020", "GO:0016780"], "go_terms": ["GO:0008654:phospholipid biosynthetic process:P", "GO:0016020:membrane:C", "GO:0016780:phosphotransferase activity, for other substituted phosphate groups:F"], "name": "CDP-OH_P_trans", "pathway_ids": ["R-SPO-1482925", "R-SCE-1483226", "R-RNO-1483191", "R-DME-1483076", "R-MMU-1483191", "R-RNO-1483076", "R-SCE-1482925", "R-GGA-1483191", "R-DME-1483226", "R-HSA-1482925", "R-DDI-1483213", "R-HSA-1483213", "R-RNO-1482925", "R-MMU-1482925", "R-DME-1482925", "R-HSA-1483226", "R-MMU-1483076", "R-CEL-1482925", "R-RNO-1483213", "R-DRE-1483191", "R-DDI-1483191", "R-MMU-1483226", "R-HSA-1483076", "R-MMU-1483213", "R-HSA-1483191", "R-SCE-1483076", "R-SCE-1483213", "R-BTA-1483213", "R-SPO-1483076", "R-SPO-1483213", "R-SCE-1483191", "R-CEL-1483076", "R-BTA-1483191", "R-RNO-1483226", "R-SPO-1483226", "R-SPO-1483191"], "pathways": ["R-SPO-1482925:r:Acyl chain remodelling of PG", "R-SCE-1483226:r:Synthesis of PI", "R-RNO-1483191:r:Synthesis of PC", "R-DME-1483076:r:Synthesis of CL", "R-MMU-1483191:r:Synthesis of PC", "R-RNO-1483076:r:Synthesis of CL", "R-SCE-1482925:r:Acyl chain remodelling of PG", "R-GGA-1483191:r:Synthesis of PC", "R-DME-1483226:r:Synthesis of PI", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-DDI-1483213:r:Synthesis of PE", "R-HSA-1483213:r:Synthesis of PE", "R-RNO-1482925:r:Acyl chain remodelling of PG", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-DME-1482925:r:Acyl chain remodelling of PG", "R-HSA-1483226:r:Synthesis of PI", "R-MMU-1483076:r:Synthesis of CL", "R-CEL-1482925:r:Acyl chain remodelling of PG", "R-RNO-1483213:r:Synthesis of PE", "R-DRE-1483191:r:Synthesis of PC", "R-DDI-1483191:r:Synthesis of PC", "R-MMU-1483226:r:Synthesis of PI", "R-HSA-1483076:r:Synthesis of CL", "R-MMU-1483213:r:Synthesis of PE", "R-HSA-1483191:r:Synthesis of PC", "R-SCE-1483076:r:Synthesis of CL", "R-SCE-1483213:r:Synthesis of PE", "R-BTA-1483213:r:Synthesis of PE", "R-SPO-1483076:r:Synthesis of CL", "R-SPO-1483213:r:Synthesis of PE", "R-SCE-1483191:r:Synthesis of PC", "R-CEL-1483076:r:Synthesis of CL", "R-BTA-1483191:r:Synthesis of PC", "R-RNO-1483226:r:Synthesis of PI", "R-SPO-1483226:r:Synthesis of PI", "R-SPO-1483191:r:Synthesis of PC"], "type": "Family"}, "IPR000465": {"description": "XPA/RAD14", "go_ids": ["GO:0003684", "GO:0006289"], "go_terms": ["GO:0003684:damaged DNA binding:F", "GO:0006289:nucleotide-excision repair:P"], "name": "XPA/RAD14", "pathway_ids": ["R-SPO-5696395", "R-MMU-5696395", "R-MMU-6781823", "R-GGA-353303", "R-SPO-5696400", "R-DME-5696400", "R-MMU-6782135", "R-DME-6781823", "R-HSA-5696395", "R-HSA-5696400", "R-HSA-6782135", "R-SPO-6782135", "R-DME-5696395", "R-DME-6782135", "R-MMU-5696400", "R-HSA-6781823", "R-SCE-6782135"], "pathways": ["R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-353303:r:Nucleotide Excision Repair", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Family"}, "IPR000467": {"description": "G-patch domain", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "G_patch_dom", "pathway_ids": ["R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-HSA-9920588", "R-RNO-72203", "R-HSA-6802952", "R-MMU-72163", "R-XTR-9770562", "R-MMU-9770562", "R-SSC-72163", "R-DME-72163", "R-RNO-72163", "R-HSA-72163", "R-SPO-9770562", "R-RNO-9770562", "R-BTA-9770562", "R-CEL-72163", "R-SPO-72163", "R-HSA-9918481", "R-SPO-72203"], "pathways": ["R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-XTR-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Domain"}, "IPR000468": {"description": "Barstar (barnase inhibitor)", "go_ids": [], "go_terms": [], "name": "Barstar", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000470": {"description": "CbxX/CfxQ, monofunctional", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "CbxX/CfqX_mono", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000471": {"description": "Interferon type I", "go_ids": ["GO:0005126", "GO:0005576", "GO:0006952"], "go_terms": ["GO:0005126:cytokine receptor binding:F", "GO:0005576:extracellular region:C", "GO:0006952:defense response:P"], "name": "Interferon_I", "pathway_ids": ["R-HSA-9833109", "R-HSA-9705671", "R-HSA-2559580", "R-HSA-983231", "R-HSA-918233", "R-HSA-933541", "R-GGA-909733", "R-RNO-912694", "R-HSA-909733", "R-RNO-909733", "R-GGA-912694", "R-HSA-912694", "R-CFA-912694", "R-MMU-909733", "R-MMU-912694", "R-CFA-909733"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-RNO-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-GGA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-CFA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-CFA-909733:r:Interferon alpha/beta signaling"], "type": "Family"}, "IPR000472": {"description": "Activin types I and II receptor domain", "go_ids": ["GO:0004675", "GO:0016020"], "go_terms": ["GO:0004675:transmembrane receptor protein serine/threonine kinase activity:F", "GO:0016020:membrane:C"], "name": "Activin_recp", "pathway_ids": ["R-MMU-9839406", "R-HSA-9839406", "R-BTA-5689880", "R-HSA-3656535", "R-HSA-5689880", "R-BTA-201451", "R-HSA-201451", "R-MMU-2173791", "R-GGA-1502540", "R-RNO-2173788", "R-BTA-2173789", "R-HSA-3656532", "R-MMU-5689880", "R-HSA-9839389", "R-BTA-9839389", "R-HSA-1181150", "R-MMU-201451", "R-RNO-201451", "R-RNO-9839389", "R-RNO-2173789", "R-HSA-2173789", "R-MMU-1502540", "R-HSA-3645790", "R-MMU-2173789", "R-MMU-9839389", "R-HSA-2173791", "R-BTA-2173791", "R-GGA-201451", "R-HSA-3304356", "R-BTA-1502540", "R-HSA-1502540", "R-BTA-2173788", "R-BTA-9839406", "R-RNO-5689880", "R-RNO-2173791", "R-GGA-9839406", "R-RNO-1502540", "R-HSA-5689603", "R-MMU-2173788", "R-HSA-2173788", "R-HSA-1433617", "R-RNO-9839406"], "pathways": ["R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-1502540:r:Signaling by Activin", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-1181150:r:Signaling by NODAL", "R-MMU-201451:r:Signaling by BMP", "R-RNO-201451:r:Signaling by BMP", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-1502540:r:Signaling by Activin", "R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-201451:r:Signaling by BMP", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-BTA-1502540:r:Signaling by Activin", "R-HSA-1502540:r:Signaling by Activin", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-9839406:r:TGFBR3 regulates activin signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-9839406:r:TGFBR3 regulates activin signaling", "R-RNO-1502540:r:Signaling by Activin", "R-HSA-5689603:r:UCH proteinases", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-RNO-9839406:r:TGFBR3 regulates activin signaling"], "type": "Domain"}, "IPR000473": {"description": "Large ribosomal subunit protein bL36", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bL36", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-HSA-5389840", "R-DRE-5389840", "R-MMU-5389840", "R-RNO-5389840", "R-DRE-5419276"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR000475": {"description": "Retroviral Vif (Viral infectivity) protein", "go_ids": ["GO:0019058"], "go_terms": ["GO:0019058:viral life cycle:P"], "name": "Vif", "pathway_ids": ["R-HSA-180585", "R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-164843", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164525", "R-HSA-173107", "R-HSA-162594"], "pathways": ["R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Family"}, "IPR000476": {"description": "Glycoprotein hormone alpha chain", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Glyco_hormone", "pathway_ids": ["R-HSA-975578", "R-SSC-193993", "R-SSC-209968", "R-RNO-193993", "R-BTA-8866910", "R-BTA-375281", "R-RNO-193048", "R-HSA-209968", "R-SSC-8866910", "R-HSA-193993", "R-HSA-8866910", "R-HSA-193048", "R-SSC-975578", "R-MMU-193048", "R-BTA-193993", "R-RNO-8866910", "R-RNO-209968", "R-RNO-375281", "R-BTA-209968", "R-HSA-418555", "R-BTA-975578", "R-MMU-375281", "R-SSC-193048", "R-MMU-193993", "R-BTA-193048", "R-MMU-8866910", "R-SSC-375281", "R-HSA-375281", "R-HSA-209822", "R-SSC-209822", "R-BTA-418555", "R-MMU-209822", "R-RNO-209822", "R-MMU-209968", "R-MMU-975578", "R-MMU-418555", "R-BTA-209822"], "pathways": ["R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-SSC-193993:r:Mineralocorticoid biosynthesis", "R-SSC-209968:r:Thyroxine biosynthesis", "R-RNO-193993:r:Mineralocorticoid biosynthesis", "R-BTA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-375281:r:Hormone ligand-binding receptors", "R-RNO-193048:r:Androgen biosynthesis", "R-HSA-209968:r:Thyroxine biosynthesis", "R-SSC-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-HSA-193993:r:Mineralocorticoid biosynthesis", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-HSA-193048:r:Androgen biosynthesis", "R-SSC-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-193048:r:Androgen biosynthesis", "R-BTA-193993:r:Mineralocorticoid biosynthesis", "R-RNO-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-RNO-209968:r:Thyroxine biosynthesis", "R-RNO-375281:r:Hormone ligand-binding receptors", "R-BTA-209968:r:Thyroxine biosynthesis", "R-HSA-418555:r:G alpha (s) signalling events", "R-BTA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-375281:r:Hormone ligand-binding receptors", "R-SSC-193048:r:Androgen biosynthesis", "R-MMU-193993:r:Mineralocorticoid biosynthesis", "R-BTA-193048:r:Androgen biosynthesis", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-SSC-375281:r:Hormone ligand-binding receptors", "R-HSA-375281:r:Hormone ligand-binding receptors", "R-HSA-209822:r:Glycoprotein hormones", "R-SSC-209822:r:Glycoprotein hormones", "R-BTA-418555:r:G alpha (s) signalling events", "R-MMU-209822:r:Glycoprotein hormones", "R-RNO-209822:r:Glycoprotein hormones", "R-MMU-209968:r:Thyroxine biosynthesis", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-418555:r:G alpha (s) signalling events", "R-BTA-209822:r:Glycoprotein hormones"], "type": "Family"}, "IPR000477": {"description": "Reverse transcriptase domain", "go_ids": [], "go_terms": [], "name": "RT_dom", "pathway_ids": ["R-HSA-9825895", "R-HSA-180910", "R-RNO-201722", "R-HSA-164516", "R-MMU-201722", "R-HSA-162585", "R-HSA-162588", "R-RNO-171319", "R-HSA-180689", "R-HSA-164843", "R-HSA-171319", "R-MMU-171319", "R-HSA-164525", "R-HSA-162594", "R-HSA-201722", "R-HSA-162592", "R-HSA-177539", "R-HSA-175567", "R-HSA-175474", "R-HSA-173107"], "pathways": ["R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-173107:r:Binding and entry of HIV virion"], "type": "Domain"}, "IPR000479": {"description": "Cation-independent mannose-6-phosphate receptor repeat", "go_ids": ["GO:0005537", "GO:0038023", "GO:0007041"], "go_terms": ["GO:0005537:D-mannose binding:F", "GO:0038023:signaling receptor activity:F", "GO:0007041:lysosomal transport:P"], "name": "CIMR_rpt", "pathway_ids": ["R-HSA-6798695", "R-MMU-8856828", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-432722", "R-MMU-6798695", "R-HSA-432722", "R-HSA-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Repeat"}, "IPR000483": {"description": "Cysteine-rich flanking region, C-terminal", "go_ids": [], "go_terms": [], "name": 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"R-HSA-388844", "R-HSA-5620916", "R-CEL-2243919", "R-HSA-9824856", "R-HSA-9028335", "R-HSA-5686938", "R-HSA-9032845", "R-DME-376176", "R-MMU-9824878", "R-MMU-936964", "R-HSA-975871", "R-MMU-977606", "R-HSA-9603505", "R-HSA-8985801", "R-RNO-9603381", "R-MMU-9028731", "R-HSA-376176", "R-XTR-5654687", "R-HSA-5602566", "R-HSA-9707616", "R-MMU-1257604", "R-HSA-9034864", "R-BTA-8849932", "R-HSA-6807004", "R-HSA-168142", "R-HSA-5603037", "R-HSA-9034013", "R-HSA-193634", "R-RNO-9032759", "R-HSA-187706", "R-HSA-187024", "R-CEL-8941413", "R-HSA-170968", "R-MMU-9032759", "R-HSA-428540", "R-MMU-5654687", "R-HSA-5602498", "R-MMU-6807004", "R-HSA-140534", "R-HSA-5682910", "R-HSA-428890", "R-MMU-2562578", "R-MMU-9013149", "R-GGA-388844", "R-MMU-937041", "R-HSA-6798695", "R-GGA-433822", "R-MMU-163125", "R-MMU-4641263", "R-HSA-187042", "R-MMU-76009", "R-HSA-9828211", "R-HSA-166016", "R-CEL-6798695", "R-HSA-430116", "R-BTA-5682910", "R-MMU-9013404", "R-HSA-9026519", "R-MMU-2243919", "R-HSA-936964", "R-HSA-9926550", "R-HSA-177929", "R-MMU-975163", "R-RNO-9034013", "R-RNO-9026527", "R-HSA-168176", "R-DME-214844", "R-HSA-1461957", "R-HSA-381426", "R-MMU-140534", "R-HSA-166058", "R-MMU-5620916", "R-MMU-166016", "R-GGA-1461957", "R-MMU-8849932", "R-HSA-9034793", "R-MMU-140837", "R-HSA-9024909", "R-MMU-1461957", "R-HSA-2219530", "R-GGA-6798695", "R-RNO-163125", "R-HSA-9013404", "R-RNO-381426", "R-HSA-6811558", "R-HSA-75892", "R-HSA-9013149", "R-HSA-9673221", "R-HSA-5603041", "R-MMU-6798695", "R-HSA-975110", "R-GGA-5654687", "R-HSA-1257604", "R-RNO-9028731", "R-RNO-8849932", "R-MMU-9034013", "R-HSA-9013957", "R-HSA-198203", "R-MMU-114608", "R-CEL-209968", "R-RNO-430116", "R-HSA-168188", "R-HSA-167044", "R-HSA-975138", "R-HSA-5602571", "R-HSA-9725554", "R-HSA-9034015", "R-HSA-5654687", "R-MMU-9010553", "R-HSA-9032759", "R-BTA-114608", "R-HSA-76009", "R-HSA-5602410", "R-HSA-168181", "R-HSA-977606", "R-GGA-6811558", "R-MMU-168181", "R-RNO-5654687", "R-HSA-9833110", "R-DME-428890", "R-HSA-937072", "R-HSA-9918481", "R-HSA-9025046", "R-HSA-9028731", "R-GGA-1257604", "R-MMU-9603381", "R-MMU-177929", "R-HSA-9013973", "R-RNO-9034793", "R-HSA-428542", "R-MMU-428890", "R-HSA-9679191", "R-HSA-9032500", "R-MMU-8985586", "R-HSA-166166", "R-HSA-975155", "R-HSA-1810476", "R-HSA-1679131", "R-HSA-9830674", "R-HSA-428543", "R-HSA-8985586", "R-HSA-2562578", "R-HSA-177504", "R-HSA-9692916", "R-HSA-9014325", "R-CEL-376176", "R-HSA-9637628", "R-HSA-975163"], "pathways": ["R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-167021:r:PLC-gamma1 signalling", "R-HSA-198745:r:Signalling to STAT3", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-MMU-9707616:r:Heme signaling", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-GGA-517856:r:TLR2 subfamily cascade", "R-HSA-5602415:r:UNC93B1 deficiency - HSE", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-5682910:r:LGI-ADAM interactions", "R-BTA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-GGA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-376176:r:Signaling by ROBO receptors", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-MMU-5682910:r:LGI-ADAM interactions", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-GGA-451514:r:MyD88:TIRAP-dependent cascade initiated on plasma membrane", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-HSA-9824856:r:Defective regulation of TLR7 by endogenous ligand", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-DME-376176:r:Signaling by ROBO receptors", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-376176:r:Signaling by ROBO receptors", "R-XTR-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-5602566:r:TICAM1 deficiency - HSE", "R-HSA-9707616:r:Heme signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-HSA-187024:r:NGF-independant TRKA activation", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-170968:r:Frs2-mediated activation", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-HSA-428540:r:Activation of RAC1", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-187042:r:TRKA activation by NGF", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-BTA-5682910:r:LGI-ADAM interactions", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-HSA-1461957:r:Beta defensins", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-GGA-1461957:r:Beta defensins", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-MMU-1461957:r:Beta defensins", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9673221:r:Defective F9 activation", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-GGA-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-HSA-198203:r:PI3K/AKT activation", "R-MMU-114608:r:Platelet degranulation", "R-CEL-209968:r:Thyroxine biosynthesis", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-HSA-168188:r:Toll Like Receptor TLR6:TLR2 Cascade", "R-HSA-167044:r:Signalling to RAS", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-5602410:r:TLR3 deficiency - HSE", "R-HSA-168181:r:Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-168181:r:Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-9833110:r:RSV-host interactions", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-177929:r:Signaling by EGFR", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Domain"}, "IPR000484": {"description": "Photosynthetic reaction centre, L/M", "go_ids": ["GO:0009772", "GO:0019684"], "go_terms": ["GO:0009772:photosynthetic electron transport in photosystem II:P", "GO:0019684:photosynthesis, light reaction:P"], "name": "Photo_RC_L/M", "pathway_ids": ["PWY-101"], "pathways": ["PWY-101:t:photosynthesis light reactions"], "type": "Family"}, "IPR000485": {"description": "AsnC-type HTH domain", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "AsnC-type_HTH_dom", "pathway_ids": ["R-HSA-9637628"], "pathways": ["R-HSA-9637628:r:Modulation by Mtb of host immune system"], "type": "Domain"}, "IPR000487": {"description": "Non-structural protein NS2B, flavivirus", "go_ids": ["GO:0004252", "GO:0044423"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0044423:virion component:C"], "name": "Flavi_NS2B", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR000488": {"description": "Death domain", "go_ids": ["GO:0005515", "GO:0007165"], "go_terms": ["GO:0005515:protein binding:F", "GO:0007165:signal transduction:P"], "name": "Death_dom", "pathway_ids": ["R-HSA-9020702", "R-HSA-5218900", "R-HSA-4755510", "R-HSA-168638", "R-HSA-5626978", "R-MMU-6811558", "R-HSA-5689880", "R-BTA-5357786", "R-MMU-9020702", "R-HSA-73856", "R-MMU-937072", "R-DME-937072", "R-BTA-975144", "R-MMU-3134963", "R-RNO-193692", "R-MMU-933542", "R-XTR-209543", "R-MMU-5689896", "R-MMU-937042", "R-BTA-450321", "R-MMU-5689880", "R-HSA-3134963", "R-HSA-5684264", "R-DME-209442", "R-RNO-6811558", "R-HSA-168927", "R-BTA-6811558", "R-HSA-9693928", "R-HSA-450302", "R-MMU-1810476", "R-DME-214869", "R-MMU-202733", "R-MMU-3371378", "R-HSA-937041", "R-DME-214842", "R-RNO-937042", "R-GGA-1227892", "R-HSA-447038", "R-HSA-9692913", "R-HSA-5607761", "R-MMU-3214841", "R-MMU-975144", "R-DRE-5357956", "R-HSA-205043", "R-DME-214862", "R-RNO-205025", "R-HSA-9660826", "R-RNO-975163", "R-MMU-450321", "R-HSA-373752", "R-DME-450302", "R-RNO-193634", "R-HSA-9609690", "R-RNO-209563", "R-RNO-3214841", "R-HSA-5602680", "R-HSA-69416", "R-RNO-209543", "R-HSA-209563", "R-HSA-447041", "R-MMU-69416", "R-DME-214874", "R-DRE-5357905", "R-MMU-448706", "R-MMU-5357905", "R-BTA-3371378", "R-RNO-5621575", "R-HSA-8986944", "R-MMU-5669034", "R-HSA-1236974", "R-HSA-9768727", "R-MMU-9860927", "R-RNO-6798695", "R-DME-373752", "R-DRE-5675482", "R-DRE-75893", "R-HSA-9705671", "R-HSA-937042", "R-HSA-445095", "R-BTA-5357956", "R-MMU-450302", "R-RNO-937072", "R-HSA-933542", "R-RNO-1257604", "R-DME-214863", "R-RNO-450321", "R-RNO-3134963", "R-MMU-5357956", "R-DME-450321", "R-DME-937039", "R-GGA-451514", "R-MMU-193692", "R-RNO-9860927", "R-HSA-5357905", "R-DRE-73856", "R-BTA-209543", "R-BTA-445989", "R-DME-69416", "R-MMU-6803207", "R-CEL-373752", "R-MMU-5218900", "R-RNO-205017", "R-RNO-3371378", "R-MMU-5626978", "R-DME-214416", "R-DRE-5357786", "R-MMU-205043", "R-BTA-209560", "R-MMU-202424", "R-HSA-975871", "R-DME-214411", "R-RNO-2871837", "R-DME-5357905", "R-MMU-209560", "R-HSA-6803207", "R-DME-5218900", "R-HSA-381340", "R-MMU-5675482", "R-SSC-3371378", "R-MMU-1169091", "R-MMU-1257604", "R-MMU-5607761", "R-MMU-447043", "R-HSA-5603037", "R-MMU-5676590", "R-RNO-69416", "R-DME-445989", "R-HSA-193681", "R-HSA-193634", "R-HSA-9909649", "R-BTA-75893", "R-HSA-5357956", "R-MMU-72187", "R-HSA-933543", "R-BTA-1257604", "R-HSA-205025", "R-HSA-5602498", "R-DME-9020702", "R-HSA-140534", "R-MMU-2562578", "R-SSC-75157", "R-RNO-5357786", "R-DME-214399", "R-MMU-373752", "R-BTA-5357905", "R-MMU-937041", "R-HSA-202733", "R-CEL-9020702", "R-HSA-937039", "R-BTA-2562578", "R-HSA-1989781", "R-GGA-433822", "R-HSA-6798695", "R-BTA-69416", "R-RNO-9020702", "R-MMU-5607764", "R-DME-214397", "R-HSA-5689896", "R-HSA-5669034", "R-RNO-5357905", "R-HSA-9818749", "R-HSA-75893", "R-HSA-5676590", "R-HSA-72187", "R-HSA-9686347", "R-RNO-448706", "R-BTA-140534", "R-HSA-450321", "R-SSC-69416", "R-MMU-445989", "R-RNO-5626978", "R-BTA-5675482", "R-RNO-202424", "R-RNO-205043", "R-MMU-975163", "R-DME-214844", "R-MMU-193634", "R-HSA-6783783", "R-MMU-75893", "R-HSA-447043", "R-MMU-5684264", "R-HSA-5603029", "R-MMU-140534", "R-HSA-166058", "R-BTA-937042", "R-HSA-193670", "R-HSA-209560", "R-MMU-5621575", "R-MMU-209543", "R-HSA-975144", "R-HSA-5675482", "R-RNO-209560", "R-MMU-73856", "R-GGA-434131", "R-HSA-75158", "R-HSA-5357786", "R-MMU-159236", "R-DME-3371378", "R-HSA-6811558", "R-HSA-1169091", "R-DRE-209543", "R-MMU-2871837", "R-MMU-445095", "R-RNO-450302", "R-RNO-445989", "R-MMU-6798695", "R-HSA-975110", "R-HSA-5603041", "R-HSA-9860927", "R-HSA-159236", "R-HSA-1257604", "R-BTA-937039", "R-HSA-193692", "R-HSA-3371378", "R-HSA-9013957", "R-MMU-75158", "R-HSA-844456", "R-HSA-445989", "R-RNO-933542", "R-HSA-8853884", "R-MMU-205017", "R-DME-937042", "R-HSA-205017", "R-HSA-975138", "R-GGA-573298", "R-HSA-209543", "R-HSA-418889", "R-HSA-418886", "R-RNO-75157", "R-XTR-3134963", "R-HSA-2559582", "R-MMU-6807878", "R-MMU-75157", "R-BTA-937072", "R-MMU-205025", "R-DRE-5218900", "R-HSA-2871837", "R-MMU-5213460", "R-DRE-159236", "R-HSA-448706", "R-MMU-937039", "R-HSA-3214841", "R-HSA-5660668", "R-HSA-5621575", "R-HSA-3295583", "R-RNO-75893", "R-XTR-9020702", "R-GGA-451477", "R-RNO-373752", "R-HSA-9920951", "R-HSA-6803211", "R-HSA-937072", "R-HSA-5607764", "R-RNO-1810476", "R-DME-975144", "R-HSA-193648", "R-MMU-5357786", "R-BTA-5669034", "R-BTA-5218900", "R-BTA-75157", "R-RNO-5684264", "R-HSA-6807878", "R-DME-5675482", "R-GGA-434001", "R-DRE-3371378", "R-HSA-9679191", "R-MMU-209563", "R-HSA-975155", "R-HSA-5213460", "R-HSA-1810476", "R-RNO-5218900", "R-HSA-2562578", "R-RNO-5607764", "R-HSA-75157", "R-BTA-450302", "R-RNO-1169091", "R-HSA-9692916", "R-BTA-9020702", "R-GGA-977240", "R-RNO-5357956", "R-BTA-975163", "R-HSA-202424", "R-RNO-5669034", "R-MMU-4755510", "R-DME-975163", "R-MMU-3295583", "R-DRE-69416", "R-HSA-975163", "R-SSC-5218900"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-XTR-209543:r:p75NTR recruits signalling complexes", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-3371378:r:Regulation by c-FLIP", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-HSA-447038:r:NrCAM interactions", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DRE-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-373752:r:Netrin-1 signaling", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-209563:r:Axonal growth stimulation", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-HSA-69416:r:Dimerization of procaspase-8", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-209563:r:Axonal growth stimulation", "R-HSA-447041:r:CHL1 interactions", "R-MMU-69416:r:Dimerization of procaspase-8", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-3371378:r:Regulation by c-FLIP", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-373752:r:Netrin-1 signaling", "R-DRE-5675482:r:Regulation of necroptotic cell death", "R-DRE-75893:r:TNF signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation 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"R-HSA-72165", "R-SSC-6803529", "R-HSA-4086398", "R-HSA-167172", "R-HSA-8941326", "R-SCE-72695", "R-MMU-72695", "R-RNO-113418", "R-DME-113418", "R-HSA-8943723", "R-MMU-975957", "R-DME-72689", "R-RNO-72702", "R-DME-9013422", "R-HSA-72649", "R-MMU-156827", "R-PFA-72163", "R-RNO-111367", "R-MMU-1660499", "R-HSA-8939902", "R-HSA-975957", "R-DRE-72702", "R-MMU-72187", "R-RNO-1660499", "R-MMU-72165", "R-RNO-9770562", "R-DME-8941326", "R-MMU-9696270", "R-SSC-9770562", "R-BTA-6807505", "R-BTA-72203", "R-SPO-72163", "R-HSA-9692914", "R-XTR-72086", "R-DRE-72165", "R-HSA-112382", "R-DRE-9013422", "R-HSA-73779", "R-MMU-9013149", "R-HSA-1989781", "R-CEL-159231", "R-HSA-6804115", "R-MMU-72203", "R-HSA-9013422", "R-CEL-975957", "R-MMU-113418", "R-DME-6781823", "R-HSA-8948700", "R-HSA-72187", "R-MMU-9013404", "R-DME-9930044", "R-RNO-72695", "R-BTA-72689", "R-DRE-6807505", "R-HSA-975956", "R-HSA-159230", "R-RNO-159230", "R-MMU-9013422", "R-CEL-159230", "R-SPO-9696273", "R-BTA-429947", "R-HSA-9635465", "R-BTA-72695", "R-BTA-9013418", "R-HSA-5655302", "R-HSA-9018519", "R-RNO-3899300", "R-HSA-9629569", "R-RNO-975957", "R-MMU-8936459", "R-CEL-6807505", "R-DRE-72695", "R-RNO-72203", "R-BTA-450408", "R-DDI-72695", "R-HSA-6784531", "R-MMU-73856", "R-DME-9629569", "R-HSA-8950505", "R-DDI-72203", "R-MMU-450520", "R-DDI-72086", "R-RNO-9696273", "R-CEL-113418", "R-MMU-674695", "R-SPO-77595", "R-RNO-429947", "R-HSA-2151209", "R-CEL-156827", "R-BTA-9930044", "R-DDI-6807505", "R-HSA-9768778", "R-SPO-4570464", "R-DME-72165", "R-XTR-9930044", "R-HSA-9854907", "R-HSA-6791226", "R-RNO-975956", "R-SCE-674695", "R-SPO-156827", "R-MMU-6804115", "R-MMU-6782210", "R-SPO-429947", "R-DME-450408", "R-DDI-72702", "R-DME-111367", "R-HSA-8853884", "R-CEL-111367", "R-DME-156827", "R-MMU-6782135", "R-DME-77595", "R-RNO-9696270", "R-HSA-2559585", "R-BTA-77588", "R-DME-159236", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-CEL-73856", "R-DDI-9770562", "R-XTR-975956", "R-RNO-72689", "R-HSA-5628897", "R-XTR-72165", "R-HSA-167162", "R-HSA-1912408", "R-XTR-975957", "R-DRE-159236", "R-HSA-9615017", "R-SCE-975957", "R-HSA-3214841", "R-HSA-167152", "R-HSA-77588", "R-HSA-111367", "R-MMU-1855183", "R-MMU-1855204", "R-HSA-9029569", "R-HSA-9918481", "R-BTA-6796648", "R-SCE-72203", "R-BTA-77595", "R-XTR-72695", "R-DRE-156827", "R-DRE-975956", "R-DME-975956", "R-GGA-72165", "R-SPO-72649", "R-SPO-72695", "R-SCE-113418", "R-DRE-72203", "R-XTR-156827", "R-RNO-75094", "R-HSA-6782135", "R-DRE-975957", "R-MMU-75094", "R-DRE-450408", "R-DME-9013418", "R-DME-159230", "R-DRE-3214841", "R-DME-8936459", "R-DRE-674695", "R-HSA-5687128", "R-MMU-166208", "R-MMU-4419969", "R-BTA-159236", "R-MMU-9634638", "R-RNO-77588", "R-HSA-9696273"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-SPO-9930044:r:Nuclear RNA decay", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-XTR-113418:r:Formation of the Early Elongation Complex", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SSC-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-DRE-9930044:r:Nuclear RNA decay", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-DME-72086:r:mRNA Capping", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-72200:r:mRNA Editing: C to U Conversion", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-SCE-166208:r:mTORC1-mediated signalling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-9930044:r:Nuclear RNA decay", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-XTR-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-168315:r:Inhibition of Host mRNA Processing and RNA Silencing", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-72086:r:mRNA Capping", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-SCE-429947:r:Deadenylation of mRNA", "R-RNO-9634638:r:Estrogen-dependent nuclear events 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Minor Pathway", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-9022707:r:MECP2 regulates transcription factors", "R-SPO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-XTR-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-XTR-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-XTR-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9707616:r:Heme signaling", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-SSC-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-MMU-9629569:r:Protein hydroxylation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-CEL-6803529:r:FGFR2 alternative splicing", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-8951664:r:Neddylation", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8941326:r:RUNX2 regulates bone development", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-SSC-73856:r:RNA Polymerase II Transcription Termination", "R-SPO-72086:r:mRNA Capping", "R-RNO-72200:r:mRNA Editing: C to U Conversion", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-SCE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-75094:r:Formation of the Editosome", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-9770562:r:mRNA Polyadenylation", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-9930044:r:Nuclear RNA decay", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9930044:r:Nuclear RNA decay", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-SSC-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-DDI-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-6803529:r:FGFR2 alternative splicing", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-RNO-72086:r:mRNA Capping", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-SCE-72086:r:mRNA Capping", "R-CEL-8941326:r:RUNX2 regulates bone development", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-DRE-72649:r:Translation initiation complex formation", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-SCE-72649:r:Translation initiation complex formation", "R-DDI-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9013408:r:RHOG GTPase cycle", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-429947:r:Deadenylation of mRNA", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-72649:r:Translation initiation complex formation", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-167161:r:HIV Transcription Initiation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-6803529:r:FGFR2 alternative splicing", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-CEL-72649:r:Translation initiation complex formation", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-429947:r:Deadenylation of mRNA", "R-XTR-9770562:r:mRNA Polyadenylation", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SSC-72187:r:mRNA 3'-end processing", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-XTR-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-GGA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-GGA-9770562:r:mRNA Polyadenylation", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-SSC-6803529:r:FGFR2 alternative splicing", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-PFA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-DME-8941326:r:RUNX2 regulates bone development", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SSC-9770562:r:mRNA Polyadenylation", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-XTR-72086:r:mRNA Capping", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-1989781:r:PPARA activates gene expression", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DME-9930044:r:Nuclear RNA decay", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-SPO-9696273:r:RND1 GTPase cycle", "R-BTA-429947:r:Deadenylation of mRNA", "R-HSA-9635465:r:Suppression of apoptosis", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9629569:r:Protein hydroxylation", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DME-9629569:r:Protein hydroxylation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-DDI-72086:r:mRNA Capping", "R-RNO-9696273:r:RND1 GTPase cycle", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-429947:r:Deadenylation of mRNA", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9930044:r:Nuclear RNA decay", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-XTR-9930044:r:Nuclear RNA decay", "R-HSA-9854907:r:Regulation of MITF-M dependent genes involved in metabolism", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-429947:r:Deadenylation of mRNA", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DME-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-BTA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated 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"R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR000506": {"description": "Ketol-acid reductoisomerase, C-terminal", "go_ids": ["GO:0004455", "GO:0009082"], "go_terms": ["GO:0004455:ketol-acid reductoisomerase activity:F", "GO:0009082:branched-chain amino acid biosynthetic process:P"], "name": "KARI_C", "pathway_ids": ["PWY-7111", "PWY-5103"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol 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"R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72706:r:GTP 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"R-XTR-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-HSA-192823:r:Viral mRNA Translation", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000510": {"description": "Nitrogenase/oxidoreductase, component 1", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Nase/OxRdtase_comp1", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Domain"}, "IPR000511": {"description": "Holocytochrome c/c1 synthase", "go_ids": ["GO:0004408", "GO:0005739"], "go_terms": ["GO:0004408:holocytochrome-c synthase activity:F", "GO:0005739:mitochondrion:C"], "name": "Holocyt_c/c1_synthase", "pathway_ids": ["PWY-8146", "PWY-8145", "R-DDI-611105", "R-SPO-611105", "R-HSA-611105", "R-SCE-611105", "R-CEL-611105", "R-GGA-611105", "R-BTA-611105", "R-MMU-611105"], "pathways": ["PWY-8146:t:cytochrome c biogenesis (system II type)", "PWY-8145:t:cytochrome c biogenesis (system III type)", "R-DDI-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-CEL-611105:r:Respiratory electron transport", "R-GGA-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR000512": {"description": "Diphtheria toxin (NAD+-dipthamide ADP-ribosyltransferase)", "go_ids": ["GO:0047286", "GO:0090729", "GO:0005576"], "go_terms": ["GO:0047286:NAD+-diphthamide ADP-ribosyltransferase activity:F", "GO:0090729:toxin activity:F", "GO:0005576:extracellular region:C"], "name": "Diphtheria_toxin", "pathway_ids": ["R-HSA-5336415"], "pathways": ["R-HSA-5336415:r:Uptake and function of diphtheria toxin"], "type": "Family"}, "IPR000514": {"description": "Glycoside hydrolase, family 39", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_39", "pathway_ids": ["R-HSA-2024101", "R-HSA-2206302", "R-CFA-2024096", "R-HSA-9953038", "R-MMU-2024096", "R-DME-2024101", "R-CFA-2024101", "R-HSA-2024096", "R-MMU-2024101", "R-DME-2024096"], "pathways": ["R-HSA-2024101:r:CS/DS degradation", "R-HSA-2206302:r:MPS I - Hurler syndrome (HS-GAG degradation)", "R-CFA-2024096:r:HS-GAG degradation", "R-HSA-9953038:r:MPS I - Hurler syndrome (CS/DS degradation)", "R-MMU-2024096:r:HS-GAG degradation", "R-DME-2024101:r:CS/DS degradation", "R-CFA-2024101:r:CS/DS degradation", "R-HSA-2024096:r:HS-GAG degradation", "R-MMU-2024101:r:CS/DS degradation", "R-DME-2024096:r:HS-GAG degradation"], "type": "Family"}, "IPR000515": {"description": "ABC transporter type 1, transmembrane domain MetI-like", "go_ids": ["GO:0016020", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "MetI-like", "pathway_ids": ["R-HSA-9927020", "R-HSA-1222538"], "pathways": ["R-HSA-9927020:r:Heme assimilation", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Domain"}, "IPR000516": {"description": "Nickel-dependent hydrogenase b-type cytochrome subunit", "go_ids": ["GO:0005506", "GO:0009055", "GO:0016020"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0009055:electron transfer activity:F", "GO:0016020:membrane:C"], "name": "Ni-dep_Hydgase_cyt-B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000518": {"description": "Metallothionein, family 14, prokaryote", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Metalthion_fam14_prok", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000519": {"description": "P-type trefoil domain", "go_ids": [], "go_terms": [], "name": "P_trefoil_dom", "pathway_ids": ["R-MMU-70221", "R-HSA-6798695", "R-HSA-189085", "R-MMU-2534343", "R-HSA-70221", "R-HSA-5357609", "R-BTA-6798695", "R-SSC-2534343", "R-BTA-2534343", "R-RNO-70221", "R-HSA-2534343", "R-HSA-5659898", "R-MMU-6798695", "R-RNO-189085", "R-MMU-189085", "R-SSC-189085", "R-HSA-9018519", "R-RNO-6798695", "R-BTA-70221"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-5357609:r:Glycogen storage disease type II (GAA)", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-BTA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-5659898:r:Intestinal saccharidase deficiencies", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-SSC-189085:r:Digestion of dietary carbohydrate", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-70221:r:Glycogen breakdown (glycogenolysis)"], "type": "Domain"}, "IPR000522": {"description": "ABC transporter, permease protein, BtuC-like", "go_ids": ["GO:0016020", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0022857:transmembrane transporter activity:F"], "name": "ABC_transptr_permease_BtuC", "pathway_ids": ["R-HSA-9638334", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR000523": {"description": "Magnesium chelatase ChlI-like, catalytic domain", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "Mg_chelatse_chII-like_cat_dom", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Domain"}, "IPR000524": {"description": "Transcription regulator HTH, GntR", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Tscrpt_reg_HTH_GntR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000525": {"description": "Initiator Rep protein, WH1 domain", "go_ids": ["GO:0003887", "GO:0006270"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006270:DNA replication initiation:P"], "name": "Initiator_Rep_WH1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000526": {"description": "Auxin-binding protein", "go_ids": ["GO:0010011"], "go_terms": ["GO:0010011:auxin binding:F"], "name": "Auxin-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000527": {"description": "Flagellar L-ring protein", "go_ids": ["GO:0003774", "GO:0009427", "GO:0071973"], "go_terms": ["GO:0003774:cytoskeletal motor activity:F", "GO:0009427:bacterial-type flagellum basal body, distal rod, L ring:C", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "Flag_Lring", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000528": {"description": "Plant non-specific lipid-transfer protein/Par allergen", "go_ids": ["GO:0006869", "GO:0008289"], "go_terms": ["GO:0006869:lipid transport:P", "GO:0008289:lipid binding:F"], "name": "Plant_nsLTP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000529": {"description": "Small ribosomal subunit protein bS6", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412", "GO:0019843"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P", "GO:0019843:rRNA binding:F"], "name": "Ribosomal_bS6", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383", "R-DME-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR000531": {"description": "TonB-dependent receptor-like, beta-barrel", "go_ids": [], "go_terms": [], "name": "Beta-barrel_TonB", "pathway_ids": ["R-HSA-9638334", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR000532": {"description": "Glucagon/GIP/secretin/VIP", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Glucagon_GIP_secretin_VIP", "pathway_ids": ["R-MMU-416476", "R-MMU-381771", "R-GGA-422085", "R-GGA-416476", "R-SSC-163359", "R-HSA-416476", "R-BTA-420092", "R-SSC-420092", "R-MMU-381676", "R-MMU-422085", "R-SSC-381771", "R-BTA-381771", "R-RNO-420092", "R-RNO-381771", "R-RNO-400511", "R-HSA-420092", "R-RNO-422085", "R-BTA-163359", "R-HSA-381771", "R-MMU-163359", "R-RNO-416476", "R-HSA-163359", "R-HSA-400511", "R-BTA-381676", "R-SSC-422085", "R-HSA-418555", "R-GGA-420092", "R-GGA-381771", "R-RNO-163359", "R-RNO-381676", "R-SSC-416476", "R-HSA-422085", "R-MMU-420092", "R-BTA-416476", "R-BTA-422085", "R-GGA-418555", "R-MMU-400511", "R-HSA-187024", "R-HSA-381676", "R-BTA-418555", "R-GGA-163359", "R-MMU-418555"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-GGA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-GGA-416476:r:G alpha (q) signalling events", "R-SSC-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-416476:r:G alpha (q) signalling events", "R-BTA-420092:r:Glucagon-type ligand receptors", "R-SSC-420092:r:Glucagon-type ligand receptors", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-SSC-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-BTA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-RNO-420092:r:Glucagon-type ligand receptors", "R-RNO-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-RNO-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-HSA-420092:r:Glucagon-type ligand receptors", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-MMU-163359:r:Glucagon signaling in metabolic regulation", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SSC-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-418555:r:G alpha (s) signalling events", "R-GGA-420092:r:Glucagon-type ligand receptors", "R-GGA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-RNO-163359:r:Glucagon signaling in metabolic regulation", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SSC-416476:r:G alpha (q) signalling events", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-420092:r:Glucagon-type ligand receptors", "R-BTA-416476:r:G alpha (q) signalling events", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-GGA-418555:r:G alpha (s) signalling events", "R-MMU-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-418555:r:G alpha (s) signalling events", "R-GGA-163359:r:Glucagon signaling in metabolic regulation", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Domain"}, "IPR000533": {"description": "Tropomyosin", "go_ids": [], "go_terms": [], "name": "Tropomyosin", "pathway_ids": ["R-RNO-390522", "R-GGA-445355", "R-HSA-445355", "R-SSC-9013424", "R-BTA-9013424", "R-MMU-390522", "R-MMU-9013424", "R-CEL-9013424", "R-HSA-9013424", "R-DME-9013424", "R-DME-445355", "R-MMU-445355", "R-BTA-390522", "R-SSC-390522", "R-BTA-445355", "R-RNO-445355", "R-RNO-9013424", "R-GGA-390522", "R-SSC-445355", "R-CEL-445355", "R-HSA-390522", "R-SPO-9013424", "R-SCE-9013424", "R-HSA-9725370"], "pathways": ["R-RNO-390522:r:Striated Muscle Contraction", "R-GGA-445355:r:Smooth Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-SSC-9013424:r:RHOV GTPase cycle", "R-BTA-9013424:r:RHOV GTPase cycle", "R-MMU-390522:r:Striated Muscle Contraction", "R-MMU-9013424:r:RHOV GTPase cycle", "R-CEL-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-DME-445355:r:Smooth Muscle Contraction", "R-MMU-445355:r:Smooth Muscle Contraction", "R-BTA-390522:r:Striated Muscle Contraction", "R-SSC-390522:r:Striated Muscle Contraction", "R-BTA-445355:r:Smooth Muscle Contraction", "R-RNO-445355:r:Smooth Muscle Contraction", "R-RNO-9013424:r:RHOV GTPase cycle", "R-GGA-390522:r:Striated Muscle Contraction", "R-SSC-445355:r:Smooth Muscle Contraction", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-390522:r:Striated Muscle Contraction", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Family"}, "IPR000534": {"description": "Semialdehyde dehydrogenase, NAD-binding", "go_ids": ["GO:0016620", "GO:0051287"], "go_terms": ["GO:0016620:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor:F", "GO:0051287:NAD binding:F"], "name": "Semialdehyde_DH_NAD-bd", "pathway_ids": ["PWY-5154", "R-DDI-70635", "R-SCE-70635", "R-SPO-70635"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-DDI-70635:r:Urea cycle", "R-SCE-70635:r:Urea cycle", "R-SPO-70635:r:Urea cycle"], "type": "Domain"}, "IPR000535": {"description": "Major sperm protein (MSP) domain", "go_ids": [], "go_terms": [], "name": "MSP_dom", "pathway_ids": ["R-HSA-9013405", "R-HSA-6798695", "R-SPO-6798695", "R-SSC-9013404", "R-MMU-9013106", "R-SSC-9013408", "R-MMU-8980692", "R-RNO-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-BTA-6798695", "R-SSC-8980692", "R-HSA-9013106", "R-HSA-1660661", "R-MMU-9013404", "R-RNO-9609523", "R-SCE-9013106", "R-BTA-9609523", "R-HSA-9013404", "R-BTA-9013408", "R-BTA-1660661", "R-HSA-8980692", "R-SPO-9609523", "R-BTA-9013404", "R-BTA-8980692", "R-MMU-6798695", "R-SSC-9013106", "R-HSA-9013408", "R-SCE-9609523", "R-HSA-9609523", "R-RNO-9013408", "R-MMU-9609523", "R-RNO-9013106", "R-RNO-9013404", "R-BTA-9013106", "R-RNO-6798695"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-SSC-9013408:r:RHOG GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9013106:r:RHOC GTPase cycle", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9013408:r:RHOG GTPase cycle", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR000536": {"description": "Nuclear hormone receptor, ligand-binding domain", "go_ids": [], "go_terms": [], "name": "Nucl_hrmn_rcpt_lig-bd", "pathway_ids": ["R-RNO-193807", "R-SSC-1251985", "R-DRE-211976", "R-DRE-192105", "R-SSC-3371497", "R-MMU-6811558", "R-HSA-5689880", "R-HSA-8936459", "R-RNO-9009391", "R-MMU-9009391", "R-DRE-400206", "R-RNO-9018519", "R-MMU-5689896", "R-SSC-9009391", "R-BTA-9018519", "R-MMU-5689880", "R-DME-198693", "R-SSC-8939211", "R-RNO-6811558", "R-HSA-9844594", "R-SSC-383280", "R-DRE-6811558", "R-BTA-6811558", "R-CEL-159418", "R-HSA-4090294", "R-HSA-9616222", "R-DME-400206", "R-RNO-4090294", "R-RNO-383280", "R-CFA-9707564", "R-DRE-381340", "R-HSA-8931987", "R-GGA-5362517", "R-MMU-200425", "R-HSA-5674400", "R-HSA-8949275", "R-HSA-192105", "R-HSA-452723", "R-SSC-9018519", "R-DRE-9841922", "R-CFA-200425", "R-RNO-5689880", "R-MMU-8866910", "R-CEL-4090294", "R-MMU-381340", "R-MMU-9841251", "R-MMU-211976", "R-DRE-196791", "R-RNO-9841922", "R-DRE-9707564", "R-MMU-3371497", "R-MMU-193807", "R-RNO-5362517", "R-HSA-9029558", "R-RNO-198693", "R-SSC-5689896", "R-DME-200425", "R-DRE-193368", "R-HSA-1251985", "R-GGA-4090294", "R-RNO-1257604", "R-MMU-8940973", "R-RNO-3371497", "R-HSA-193368", "R-HSA-3371497", "R-GGA-9018519", "R-XTR-383280", "R-DRE-9616222", "R-HSA-5625886", "R-DRE-9623433", "R-HSA-196791", "R-BTA-4090294", "R-DME-196791", "R-CFA-400206", "R-MMU-9841922", "R-BTA-8866427", "R-MMU-4090294", "R-MMU-9029569", "R-RNO-1251985", "R-CFA-5362517", "R-HSA-9022707", "R-RNO-8866910", "R-GGA-3371497", "R-RNO-400206", "R-HSA-9839394", "R-HSA-9768777", "R-MMU-193368", "R-HSA-381340", "R-HSA-9841251", "R-HSA-9632974", "R-HSA-9707616", "R-HSA-210745", "R-MMU-1257604", "R-BTA-9009391", "R-RNO-9623433", "R-HSA-8939902", "R-MMU-1251985", "R-HSA-8866427", "R-HSA-9009391", "R-DRE-1257604", "R-BTA-383280", "R-DRE-9009391", "R-DRE-4090294", "R-HSA-200425", "R-BTA-1257604", "R-HSA-159418", "R-HSA-9031528", "R-DME-9029569", "R-HSA-2426168", "R-DME-381340", "R-HSA-9927426", "R-MMU-9707564", "R-HSA-1989781", "R-DRE-193807", "R-HSA-2151201", "R-HSA-8939256", "R-BTA-8939211", "R-BTA-9841922", "R-HSA-5689896", "R-BTA-5362517", "R-GGA-9616222", "R-BTA-8866910", "R-HSA-9927418", "R-CEL-383280", "R-HSA-1368108", "R-HSA-9841922", "R-SSC-6811558", "R-BTA-9623433", "R-DME-9623433", "R-HSA-8939211", "R-BTA-1251985", "R-DME-9616222", "R-HSA-9933387", "R-HSA-210747", "R-HSA-9707564", "R-HSA-8943724", "R-HSA-9690406", "R-HSA-9018519", "R-RNO-8866427", "R-DRE-9018519", "R-DRE-9841251", "R-MMU-8931987", "R-MMU-8939211", "R-DRE-200425", "R-DME-383280", "R-SSC-4090294", "R-CEL-9841922", "R-MMU-192105", "R-HSA-2219530", "R-HSA-6785807", "R-DRE-5362517", "R-HSA-193807", "R-MMU-9018519", "R-HSA-6811558", "R-DRE-159418", "R-RNO-196791", "R-BTA-8931987", "R-SSC-9841251", "R-MMU-8866427", "R-MMU-196791", "R-RNO-381340", "R-CFA-383280", "R-RNO-193368", "R-HSA-400206", "R-RNO-211976", "R-MMU-9616222", "R-RNO-5689896", "R-DRE-383280", "R-HSA-1257604", "R-DRE-8931987", "R-RNO-9616222", "R-HSA-211976", "R-HSA-5617472", "R-HSA-8940973", "R-MMU-400206", "R-HSA-9623433", "R-SSC-1257604", "R-HSA-198693", "R-DME-8866427", "R-RNO-9841251", "R-CEL-196791", "R-RNO-9029569", "R-DRE-9029569", "R-RNO-192105", "R-SSC-8866910", "R-MMU-383280", "R-HSA-9615017", "R-BTA-9029569", "R-RNO-159418", "R-RNO-5625886", "R-MMU-198693", "R-HSA-8866910", "R-HSA-8849473", "R-RNO-200425", "R-MMU-5625886", "R-DRE-5689896", "R-SSC-5689880", "R-SSC-8940973", "R-HSA-9029569", "R-HSA-5362517", "R-DME-4090294", "R-DRE-8939211", "R-HSA-9931509", "R-DME-159418", "R-BTA-5689896", "R-CEL-198693", "R-MMU-9623433", "R-DME-9707564", "R-HSA-9031525", "R-RNO-8931987", "R-SSC-8931987", "R-BTA-381340", "R-RNO-9707564", "R-HSA-9679191", "R-GGA-383280", "R-SSC-5625886", "R-HSA-9931510", "R-HSA-383280", "R-DME-9841922", "R-SSC-196791", "R-MMU-5362517", "R-HSA-9831926", "R-BTA-9841251", "R-DRE-1251985", "R-HSA-2892247", "R-RNO-8939211", "R-MMU-159418", "R-DME-5362517"], "pathways": ["R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-SSC-1251985:r:Nuclear signaling by ERBB4", "R-DRE-211976:r:Endogenous sterols", "R-DRE-192105:r:Synthesis of bile acids and bile salts", "R-SSC-3371497:r:HSP90 chaperone cycle for 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biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-XTR-6806664:r:Metabolism of vitamin K", "R-DDI-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis", "R-HSA-6806664:r:Metabolism of vitamin K", "R-MMU-6806664:r:Metabolism of vitamin K", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-DME-1268020:r:Mitochondrial protein import", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-1268020:r:Mitochondrial protein import", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-MMU-1268020:r:Mitochondrial protein import", "R-RNO-6806664:r:Metabolism of vitamin K", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-CEL-1268020:r:Mitochondrial protein import", "R-DRE-6806664:r:Metabolism of vitamin K", "R-CEL-2142789:r:Ubiquinol biosynthesis", "R-RNO-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR000538": {"description": "Link domain", "go_ids": ["GO:0005540", "GO:0007155"], "go_terms": ["GO:0005540:hyaluronic acid binding:F", "GO:0007155:cell adhesion:P"], "name": "Link_dom", "pathway_ids": ["R-HSA-6798695", "R-RNO-2022923", "R-HSA-3560783", "R-RNO-1474228", "R-HSA-3000178", "R-RNO-2142845", "R-HSA-9927418", "R-SSC-1474228", "R-MMU-8957275", "R-BTA-8957275", "R-BTA-2142845", "R-HSA-2142845", "R-MMU-3000178", "R-RNO-202733", "R-MMU-202733", "R-MMU-381426", "R-BTA-2022870", "R-RNO-3000178", "R-MMU-2022923", "R-HSA-381426", "R-SSC-3000178", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-2024101", "R-BTA-1971475", "R-SSC-2022854", "R-HSA-2022870", "R-SSC-2022857", "R-HSA-1971475", "R-HSA-2022857", "R-MMU-2160916", "R-MMU-2142845", "R-MMU-2022854", "R-HSA-419037", "R-RNO-2022857", "R-HSA-3560801", "R-RNO-381426", "R-HSA-3656244", "R-HSA-2022854", "R-HSA-2022923", "R-HSA-3656243", "R-HSA-3656225", "R-HSA-4420332", "R-MMU-216083", "R-MMU-2024101", "R-MMU-6798695", "R-RNO-6798695", "R-MMU-2022870", "R-GGA-3000178", "R-HSA-3000497", "R-RNO-216083", "R-HSA-3595172", "R-BTA-3000178", "R-MMU-3000497", "R-HSA-373760", "R-RNO-8957275", "R-RNO-2024101", "R-BTA-381426", "R-BTA-2160916", "R-HSA-3595177", "R-HSA-9938206", "R-RNO-2022870", "R-BTA-2024101", "R-HSA-216083", "R-HSA-9927432", "R-HSA-2160916", "R-MMU-2022857", "R-RNO-1971475", "R-HSA-877300", "R-RNO-2022854", "R-HSA-8957275", "R-BTA-2022923", "R-MMU-1971475", "R-RNO-2160916", "R-HSA-202733", "R-HSA-3595174"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-2142845:r:Hyaluronan metabolism", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2142845:r:Hyaluronan metabolism", "R-HSA-2142845:r:Hyaluronan metabolism", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2024101:r:CS/DS degradation", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-SSC-2022857:r:Keratan sulfate degradation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-GGA-3000178:r:ECM proteoglycans", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-BTA-3000178:r:ECM proteoglycans", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-373760:r:L1CAM interactions", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024101:r:CS/DS degradation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-2160916:r:Hyaluronan degradation", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-BTA-2024101:r:CS/DS degradation", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-877300:r:Interferon gamma signaling", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-2160916:r:Hyaluronan degradation", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type"], "type": "Domain"}, "IPR000539": {"description": "Frizzled/Smoothened, 7TM", "go_ids": ["GO:0007166", "GO:0016020"], "go_terms": ["GO:0007166:cell surface receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "Frizzled/Smoothened_7TM", "pathway_ids": ["R-DRE-5140745", "R-RNO-5140745", "R-HSA-373080", "R-MMU-8856828", "R-MMU-5632684", "R-GGA-4608870", "R-MMU-4641263", "R-DME-216217", "R-HSA-8856828", "R-DRE-4641263", "R-MMU-4086398", "R-MMU-5099900", "R-RNO-5635838", "R-RNO-5610787", "R-DME-4086400", "R-RNO-4641263", "R-DME-350376", "R-DRE-5610787", "R-DRE-4641262", "R-DME-350411", "R-DME-4641262", "R-MMU-5610787", "R-DME-209472", "R-CEL-4086398", "R-DME-5610787", "R-HSA-5140745", "R-DME-4608870", "R-MMU-5635838", "R-RNO-4086400", "R-DRE-5620922", "R-MMU-4086400", "R-DME-5140745", "R-MMU-5140745", "R-HSA-4608870", "R-HSA-5635838", "R-MMU-4641262", "R-CEL-4608870", "R-MMU-5620922", "R-DRE-4608870", "R-HSA-5620922", "R-DME-350379", "R-RNO-5632684", "R-HSA-201681", "R-RNO-4641262", "R-MMU-8856825", "R-RNO-5620922", "R-DME-350368", "R-DME-209338", "R-DME-209214", "R-DME-5635838", "R-CEL-5140745", "R-HSA-5610787", "R-HSA-4641262", "R-HSA-5340588", "R-RNO-8856828", "R-HSA-4086398", "R-DME-209387", "R-RNO-5099900", "R-MMU-4608870", "R-DME-450728", "R-DME-216119", "R-GGA-5099900", "R-RNO-4608870", "R-DRE-5635838", "R-RNO-8856825", "R-DME-5620922", "R-HSA-4641263", "R-HSA-4086400", "R-HSA-5099900", "R-DME-350480", "R-GGA-4086398", "R-GGA-4641263", "R-HSA-9673324", "R-HSA-5632684", "R-RNO-4086398", "R-DME-209440", "R-HSA-8856825"], "pathways": ["R-DRE-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-GGA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-DME-216217:r:Activation of SMO", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DRE-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-5635838:r:Activation of SMO", "R-RNO-5610787:r:Hedgehog 'off' state", "R-DME-4086400:r:PCP/CE pathway", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-DRE-5610787:r:Hedgehog 'off' state", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-209472:r:Assembly of receptor complex", "R-CEL-4086398:r:Ca2+ pathway", "R-DME-5610787:r:Hedgehog 'off' state", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5635838:r:Activation of SMO", "R-RNO-4086400:r:PCP/CE pathway", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-4086400:r:PCP/CE pathway", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5635838:r:Activation of SMO", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209214:r:Phosphorylation of SMO", "R-DME-5635838:r:Activation of SMO", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-4086398:r:Ca2+ pathway", "R-DME-209387:r:Phosphorylation of ARR", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-DME-216119:r:Activation of CI", "R-GGA-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-DRE-5635838:r:Activation of SMO", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-GGA-4086398:r:Ca2+ pathway", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-5632684:r:Hedgehog 'on' state", "R-RNO-4086398:r:Ca2+ pathway", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis"], "type": "Domain"}, "IPR000541": {"description": "Cytoplasmic tRNA 2-thiolation protein 1", "go_ids": ["GO:0034227", "GO:0000049", "GO:0002098"], "go_terms": ["GO:0034227:tRNA thio-modification:P", "GO:0000049:tRNA binding:F", "GO:0002098:tRNA wobble uridine modification:P"], "name": "Ncs6/Tuc1/Ctu1", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-HSA-6782315"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR000542": {"description": "Acyltransferase ChoActase/COT/CPT", "go_ids": ["GO:0016746"], "go_terms": ["GO:0016746:acyltransferase activity:F"], "name": "Carn_acyl_trans", "pathway_ids": ["R-HSA-1989781", "R-SSC-264642", "R-DRE-200425", "R-DRE-1483191", "R-MMU-200425", "R-RNO-1483191", "R-MMU-1483191", "R-HSA-389887", "R-HSA-264642", "R-MMU-9033241", "R-XTR-200425", "R-DME-264642", "R-MMU-264642", "R-BTA-9033241", "R-CEL-1483191", "R-RNO-9033241", "R-HSA-1483191", "R-MMU-389887", "R-SCE-389887", "R-DRE-264642", "R-RNO-389887", "R-HSA-200425", "R-RNO-264642", "R-RNO-200425", "R-HSA-9933387", "R-SCE-264642", "R-SCE-9033241", "R-BTA-200425", "R-SCE-1483191", "R-DME-1483191", "R-HSA-9033241", "R-CEL-264642", "R-BTA-389887", "R-SSC-1483191"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-SSC-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DRE-200425:r:Carnitine shuttle", "R-DRE-1483191:r:Synthesis of PC", "R-MMU-200425:r:Carnitine shuttle", "R-RNO-1483191:r:Synthesis of PC", "R-MMU-1483191:r:Synthesis of PC", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-9033241:r:Peroxisomal protein import", "R-XTR-200425:r:Carnitine shuttle", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-9033241:r:Peroxisomal protein import", "R-CEL-1483191:r:Synthesis of PC", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-1483191:r:Synthesis of PC", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DRE-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-200425:r:Carnitine shuttle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-SCE-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SCE-9033241:r:Peroxisomal protein import", "R-BTA-200425:r:Carnitine shuttle", "R-SCE-1483191:r:Synthesis of PC", "R-DME-1483191:r:Synthesis of PC", "R-HSA-9033241:r:Peroxisomal protein import", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SSC-1483191:r:Synthesis of PC"], "type": "Family"}, "IPR000544": {"description": "Octanoyltransferase", "go_ids": ["GO:0033819", "GO:0009249"], "go_terms": ["GO:0033819:lipoyl(octanoyl) transferase activity:F", "GO:0009249:protein lipoylation:P"], "name": "Octanoyltransferase", "pathway_ids": ["PWY-7382", "PWY-6987", "R-SPO-9857492", "R-SCE-9857492", "R-DME-9857492", "R-MMU-9857492", "R-XTR-9857492", "R-HSA-9857492", "R-DRE-9857492"], "pathways": ["PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-6987:t:lipoate biosynthesis and incorporation III (Bacillus)", "R-SPO-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-DME-9857492:r:Protein lipoylation", "R-MMU-9857492:r:Protein lipoylation", "R-XTR-9857492:r:Protein lipoylation", "R-HSA-9857492:r:Protein lipoylation", "R-DRE-9857492:r:Protein lipoylation"], "type": "Family"}, "IPR000547": {"description": "Clathrin, heavy chain/VPS, 7-fold repeat", "go_ids": ["GO:0006886", "GO:0016192"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P"], "name": "Clathrin_H-chain/VPS_repeat", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-SPO-437239", "R-SCE-8856828", "R-DME-190873", "R-BTA-196025", "R-BTA-9013424", "R-HSA-9700645", "R-HSA-8856828", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-9013424", "R-CEL-432722", "R-HSA-9013424", "R-RNO-8964038", "R-BTA-190873", "R-DME-5099900", "R-MMU-9013420", "R-RNO-9013424", "R-RNO-196025", "R-RNO-177504", "R-DDI-8856828", "R-SCE-9013420", "R-DME-3928665", "R-DME-8964038", "R-DDI-8964038", "R-DME-177504", "R-HSA-5140745", "R-RNO-8866427", "R-RNO-432722", "R-MMU-196025", "R-BTA-5099900", "R-RNO-432720", "R-DME-437239", "R-HSA-432720", "R-DME-196025", "R-DME-5140745", "R-HSA-437239", "R-CEL-8866427", "R-BTA-177504", "R-MMU-5140745", "R-SPO-8866427", "R-CEL-8964038", "R-SPO-190873", "R-MMU-8866427", "R-SPO-9013424", "R-SCE-196025", "R-SPO-196025", "R-RNO-9013420", "R-CEL-8856825", "R-SCE-8866427", "R-HSA-2132295", "R-DME-432720", "R-MMU-8856825", "R-HSA-190873", "R-CEL-432720", "R-MMU-432722", "R-CEL-190873", "R-DDI-437239", "R-CEL-437239", "R-DME-8866427", "R-DME-9013424", "R-HSA-9754560", "R-SPO-8964038", "R-HSA-9725370", "R-MMU-190873", "R-CEL-5140745", "R-SCE-432720", "R-DDI-8866427", "R-RNO-190873", "R-MMU-8964038", "R-HSA-168275", "R-MMU-2132295", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-DME-8856828", "R-SPO-9013420", "R-SCE-9013424", "R-RNO-5099900", "R-SCE-8964038", "R-HSA-432722", "R-SPO-432720", "R-BTA-2132295", "R-MMU-432720", "R-BTA-8856828", "R-HSA-196025", "R-CEL-8856828", "R-BTA-9013420", "R-RNO-2132295", "R-DME-8856825", "R-HSA-9013420", "R-RNO-8856825", "R-MMU-437239", "R-RNO-437239", "R-BTA-432720", "R-CEL-196025", "R-DDI-432720", "R-HSA-5099900", "R-DME-432722", "R-MMU-9013424", "R-SPO-8856828", "R-CEL-3928665", "R-HSA-177504", "R-HSA-8866427", "R-BTA-8856825", "R-BTA-8964038", "R-HSA-8856825", "R-HSA-3928665", "R-SCE-437239", "R-MMU-177504", "R-CEL-9013420", "R-BTA-432722", "R-BTA-5140745", "R-SCE-190873", "R-HSA-8964038", "R-DME-9013420"], "pathways": ["R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-437239:r:Recycling pathway of L1", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-DME-190873:r:Gap junction degradation", "R-BTA-196025:r:Formation of annular gap junctions", "R-BTA-9013424:r:RHOV GTPase cycle", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-9013424:r:RHOV GTPase cycle", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-8964038:r:LDL clearance", "R-BTA-190873:r:Gap junction degradation", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-RNO-196025:r:Formation of annular gap junctions", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-SCE-9013420:r:RHOU GTPase cycle", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-8964038:r:LDL clearance", "R-DDI-8964038:r:LDL clearance", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-196025:r:Formation of annular gap junctions", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-196025:r:Formation of annular gap junctions", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-437239:r:Recycling pathway of L1", "R-CEL-8866427:r:VLDLR internalisation and degradation", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-CEL-8964038:r:LDL clearance", "R-SPO-190873:r:Gap junction degradation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SCE-196025:r:Formation of annular gap junctions", "R-SPO-196025:r:Formation of annular gap junctions", "R-RNO-9013420:r:RHOU GTPase cycle", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-190873:r:Gap junction degradation", "R-DDI-437239:r:Recycling pathway of L1", "R-CEL-437239:r:Recycling pathway of L1", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-SPO-8964038:r:LDL clearance", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-190873:r:Gap junction degradation", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-RNO-190873:r:Gap junction degradation", "R-MMU-8964038:r:LDL clearance", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-437239:r:Recycling pathway of L1", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-SPO-9013420:r:RHOU GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SCE-8964038:r:LDL clearance", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-196025:r:Formation of annular gap junctions", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-CEL-196025:r:Formation of annular gap junctions", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-190873:r:Gap junction degradation", "R-HSA-8964038:r:LDL clearance", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Repeat"}, "IPR000548": {"description": "Myelin basic protein", "go_ids": ["GO:0019911"], "go_terms": ["GO:0019911:structural constituent of myelin sheath:F"], "name": "Myelin_BP", "pathway_ids": ["R-HSA-9619665"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "type": "Family"}, "IPR000549": {"description": "Photosystem I reaction center subunit V/PsaK", "go_ids": ["GO:0009522", "GO:0015979", "GO:0016020"], "go_terms": ["GO:0009522:photosystem I:C", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C"], "name": "PSI_PsaG/PsaK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000550": {"description": "7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK", "go_ids": ["GO:0003848", "GO:0009396"], "go_terms": ["GO:0003848:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity:F", "GO:0009396:folic acid-containing compound biosynthetic process:P"], "name": "Hppk", "pathway_ids": ["PWY-7853", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7852", "PWY-6148"], "pathways": ["PWY-7853:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis V (Pyrococcus)", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7852:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)", "PWY-6148:t:tetrahydromethanopterin biosynthesis"], "type": "Domain"}, "IPR000551": {"description": "MerR-type HTH domain", "go_ids": ["GO:0006355", "GO:0003677"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F"], "name": "MerR-type_HTH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000552": {"description": "Large ribosomal subunit protein eL42", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL44", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-PFA-72689", "R-HSA-9010553", "R-SPO-9954714", "R-CFA-1799339", "R-SCE-9954709", "R-PFA-9954709", "R-DRE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-CFA-72706", "R-DDI-9954714", "R-CEL-72706", "R-CFA-9954709", "R-PFA-9954716", "R-CEL-9954716", "R-CEL-9954714", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-SPO-9954709", "R-HSA-9633012", "R-DRE-9954714", "R-MMU-9954714", "R-RNO-156827", "R-BTA-6791226", "R-SPO-975956", "R-SCE-975956", "R-SSC-9954714", "R-CEL-1799339", "R-SPO-72706", "R-HSA-72706", "R-CFA-6791226", "R-CEL-156827", "R-CFA-156827", "R-RNO-6791226", "R-SSC-1799339", "R-DRE-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-DDI-156827", "R-PFA-1799339", "R-RNO-9954709", "R-SSC-72689", "R-SPO-156827", "R-HSA-9954714", "R-PFA-975956", "R-CEL-72689", "R-DDI-72689", "R-CFA-9954714", "R-MMU-1799339", "R-SPO-72689", "R-DDI-975956", "R-HSA-9954716", "R-CFA-975957", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-PFA-156827", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-PFA-72706", "R-DDI-9954716", "R-SCE-1799339", "R-SPO-1799339", "R-DDI-9954709", "R-CFA-72689", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-CFA-9954716", "R-SCE-156827", "R-DRE-975956", "R-BTA-9954716", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-PFA-975957", "R-HSA-156902", "R-DRE-975957", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-CFA-975956", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-DRE-6791226", "R-SSC-6791226", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SSC-9954716", "R-RNO-72706", "R-RNO-9954714", "R-PFA-9954714"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-PFA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades 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"R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", 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"R-HSA-72702", "R-RNO-72649", "R-GGA-72649", "R-DME-75815", "R-HSA-5696394", "R-CEL-72649", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-MMU-5687128", "R-DME-72702", "R-CEL-8856825", "R-DME-5358346", "R-SPO-72689", "R-CEL-72689", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-HSA-2467813", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-MMU-72689", "R-SCE-6798695", "R-MMU-68949", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-MMU-6781823", "R-DME-9907900", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-HSA-72165", "R-BTA-174184", "R-MMU-9762114", "R-DRE-6781823", "R-MMU-195253", "R-MMU-202424", "R-MMU-5693607", "R-MMU-72695", "R-MMU-382556", "R-HSA-5610780", "R-BTA-8939236", "R-DME-209360", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-DME-72689", "R-MMU-1169091", "R-RNO-72702", "R-DME-432626", "R-HSA-72649", "R-MMU-5607761", "R-MMU-156827", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-HSA-5693571", "R-DRE-72702", "R-MMU-8939902", "R-MMU-72165", "R-DME-174178", "R-BTA-5693571", "R-SPO-72163", "R-HSA-8939236", "R-BTA-983168", "R-DDI-8854050", "R-SPO-5689901", "R-MMU-5607764", "R-DME-6781823", "R-DME-8951664", "R-DRE-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577", "R-HSA-5676590", "R-RNO-72695", "R-DDI-5632684", "R-BTA-72689", "R-BTA-9929491", "R-HSA-4641257", "R-MMU-9929491", "R-HSA-174113", "R-BTA-9932298", "R-BTA-9762114", "R-BTA-72695", "R-HSA-68867", "R-DRE-5689901", "R-MMU-9907900", "R-DME-174154", "R-CEL-4641258", "R-DRE-72695", "R-BTA-450408", "R-DDI-5658442", "R-DDI-72695", "R-HSA-8941858", "R-HSA-9755511", "R-CEL-9929491", "R-DME-9755511", "R-CEL-156827", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-HSA-5689603", "R-SPO-156827", "R-GGA-72695", "R-DME-450408", "R-DDI-72702", "R-BTA-8939902", "R-BTA-9766229", "R-HSA-5689901", "R-BTA-8951664", "R-HSA-187577", "R-DME-1169091", "R-DME-156827", "R-DDI-9755511", "R-MMU-8856825", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-BTA-8941858", "R-DME-4641258", "R-SSC-8951664", "R-HSA-174184", "R-RNO-72689", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-HSA-9918481", "R-DME-68949", "R-XTR-72695", "R-DRE-8856825", "R-DME-8856825", "R-DRE-156827", "R-CEL-1236978", "R-CEL-9954709", "R-SPO-72649", "R-SPO-72695", "R-HSA-382556", "R-XTR-156827", "R-HSA-8852276", "R-DME-538864", "R-XTR-5689901", "R-SCE-9907900", "R-HSA-5668541", "R-MTU-936654", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-HSA-5687128", "R-DME-5632684", "R-DME-432395", "R-DDI-983168", "R-MMU-983168", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DDI-5689901:r:Metalloprotease DUBs", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-432524:r:Degradation of PER", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-5689901:r:Metalloprotease DUBs", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-5689901:r:Metalloprotease DUBs", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-SPO-5689603:r:UCH proteinases", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-1236978:r:Cross-presentation of soluble 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"R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-GGA-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-RNO-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-GGA-427413:r:NoRC negatively regulates rRNA expression"], "type": "Family"}, "IPR000559": {"description": "Formate-tetrahydrofolate ligase, FTHFS", "go_ids": ["GO:0004329", "GO:0005524"], "go_terms": ["GO:0004329:formate-tetrahydrofolate ligase activity:F", "GO:0005524:ATP binding:F"], "name": 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"His_Pase_clade-2", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-DME-1855231", "R-HSA-1855167", "R-MMU-1855167", "R-RNO-1855231", "R-CEL-6798695", "R-HSA-1971475", "R-BTA-6798695", "R-HSA-1483166", "R-RNO-1855167", "R-MMU-1483166", "R-RNO-1971475", "R-SPO-1483166", "R-SPO-1855167", "R-SCE-1855167", "R-DDI-1483166", "R-BTA-1855167", "R-DME-1855167", "R-BTA-1483166", "R-CEL-1855167", "R-MMU-6798695", "R-MMU-1855231", "R-MMU-1971475", "R-HSA-1855231", "R-DDI-1855231", "R-RNO-6798695", "R-DRE-1971475"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-1855231:r:Synthesis of IPs in the ER lumen", "R-HSA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-RNO-1855231:r:Synthesis of IPs in the ER lumen", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-1483166:r:Synthesis of PA", "R-RNO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1483166:r:Synthesis of PA", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SPO-1483166:r:Synthesis of PA", "R-SPO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-SCE-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-DDI-1483166:r:Synthesis of PA", "R-BTA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-DME-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-BTA-1483166:r:Synthesis of PA", "R-CEL-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-1855231:r:Synthesis of IPs in the ER lumen", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-1855231:r:Synthesis of IPs in the ER lumen", "R-DDI-1855231:r:Synthesis of IPs in the ER lumen", "R-RNO-6798695:r:Neutrophil degranulation", "R-DRE-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis"], "type": "Family"}, "IPR000562": {"description": "Fibronectin type II domain", "go_ids": [], "go_terms": [], "name": "FN_type2_dom", "pathway_ids": ["R-MMU-8856828", "R-HSA-8874081", "R-RNO-2022090", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-RNO-1474228", "R-HSA-140837", "R-MMU-3928665", "R-HSA-9918485", "R-RNO-9009391", "R-MMU-9009391", "R-RNO-382556", "R-GGA-354192", "R-MMU-3000170", "R-HSA-6806942", "R-RNO-140837", "R-RNO-9634597", "R-GGA-9009391", "R-MMU-202733", "R-MMU-1482788", "R-HSA-6802955", "R-HSA-1474228", "R-HSA-9931269", "R-HSA-6802948", "R-RNO-1566977", "R-MMU-1592389", "R-BTA-1474228", "R-GGA-2129379", "R-MMU-9634597", "R-HSA-3000171", "R-BTA-1482839", "R-GGA-1442490", "R-MMU-1482839", "R-GGA-5674135", "R-MMU-1483166", "R-HSA-2022090", "R-HSA-1482839", "R-MMU-216083", "R-GGA-9860927", "R-RNO-5358346", "R-MMU-354192", "R-MMU-9860927", "R-RNO-6798695", "R-HSA-9656223", "R-GGA-9634597", "R-HSA-1482788", "R-HSA-9657688", "R-HSA-9634597", "R-GGA-3000178", "R-MMU-5674135", "R-RNO-216083", "R-GGA-1474228", "R-HSA-1483166", "R-HSA-1482925", "R-RNO-9860927", "R-RNO-8874081", "R-HSA-114608", "R-HSA-9638630", "R-MMU-8874081", "R-RNO-354192", "R-BTA-1483166", "R-RNO-5674135", "R-GGA-381426", "R-GGA-1592389", "R-HSA-1442490", "R-BTA-1433557", "R-HSA-1912420", "R-MMU-382556", "R-HSA-9925563", "R-HSA-2129379", "R-HSA-3000170", "R-MMU-1566977", "R-RNO-1592389", "R-MMU-354194", "R-GGA-114608", "R-BTA-9009391", "R-MMU-2022090", "R-HSA-1482801", "R-HSA-9009391", "R-HSA-8856825", "R-HSA-3928665", "R-GGA-3928665", "R-BTA-1482922", "R-BTA-3928665", "R-RNO-3000170", "R-HSA-9725370", "R-HSA-202733", "R-GGA-372708", "R-HSA-5358346", "R-HSA-6798695", "R-HSA-5674135", "R-HSA-9700645", "R-HSA-8856828", "R-BTA-1482801", "R-BTA-6798695", "R-GGA-354194", "R-MMU-8957275", "R-MMU-3000178", "R-HSA-9649948", "R-RNO-202733", "R-MMU-381426", "R-RNO-3928665", "R-GGA-8957275", "R-RNO-3000178", "R-GGA-3000170", "R-HSA-381426", "R-MMU-1474228", "R-MMU-1433557", "R-GGA-216083", "R-MMU-140837", "R-HSA-5678895", "R-RNO-9931269", "R-GGA-202733", "R-BTA-1482925", "R-HSA-6785807", "R-MMU-6811440", "R-RNO-381426", "R-RNO-1433557", "R-BTA-1592389", "R-MMU-9931269", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-372708", "R-MMU-114608", "R-HSA-901032", "R-HSA-9657689", "R-MMU-8856825", "R-BTA-1482788", "R-BTA-1442490", "R-MMU-432722", "R-RNO-354194", "R-HSA-6811440", "R-RNO-2129379", "R-RNO-114608", "R-MMU-372708", "R-HSA-1482922", "R-HSA-6802946", "R-RNO-8957275", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-1482925", "R-HSA-432722", "R-HSA-9918481", "R-RNO-1236978", "R-HSA-354192", "R-HSA-216083", "R-HSA-1566977", "R-HSA-382556", "R-HSA-1236978", "R-HSA-354194", "R-HSA-1592389", "R-HSA-1433557", "R-RNO-1442490", "R-MMU-1482922", "R-GGA-1566977", "R-MMU-6806942", "R-HSA-8957275", "R-MMU-1236978", "R-MMU-1482801", "R-MMU-1442490", "R-HSA-9637628", "R-MMU-2129379"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-GGA-354192:r:Integrin signaling", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-9634597:r:GPER1 signaling", "R-GGA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-1566977:r:Fibronectin matrix formation", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-GGA-2129379:r:Molecules associated with elastic fibres", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-GGA-1442490:r:Collagen degradation", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-216083:r:Integrin cell surface interactions", "R-GGA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-GGA-9634597:r:GPER1 signaling", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-HSA-9634597:r:GPER1 signaling", "R-GGA-3000178:r:ECM proteoglycans", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-354192:r:Integrin signaling", "R-BTA-1483166:r:Synthesis of PA", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-114608:r:Platelet degranulation", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-3000170:r:Syndecan interactions", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-BTA-6798695:r:Neutrophil degranulation", "R-GGA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000178:r:ECM proteoglycans", "R-GGA-3000170:r:Syndecan interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-GGA-216083:r:Integrin cell surface interactions", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-114608:r:Platelet degranulation", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-BTA-1442490:r:Collagen degradation", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-RNO-114608:r:Platelet degranulation", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-354192:r:Integrin signaling", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-1442490:r:Collagen degradation", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-GGA-1566977:r:Fibronectin matrix formation", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-MMU-1442490:r:Collagen degradation", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR000566": {"description": "Lipocalin/cytosolic fatty-acid binding domain", "go_ids": [], "go_terms": [], "name": "Lipocln_cytosolic_FA-bd_dom", "pathway_ids": ["R-HSA-6798695", "R-HSA-804914", "R-CEL-5365859", "R-GGA-975634", "R-CEL-6798695", "R-HSA-2168880", "R-BTA-5362517", "R-CEL-2453902", "R-BTA-6798695", "R-HSA-9841922", "R-MMU-975634", "R-BTA-2162123", "R-HSA-166665", "R-HSA-6799990", "R-CEL-159418", "R-MMU-163560", "R-HSA-9918442", "R-MMU-2168880", "R-HSA-9690406", "R-RNO-2162123", "R-RNO-5365859", "R-RNO-917937", "R-HSA-6809583", "R-RNO-2168880", "R-CEL-5362517", "R-MMU-2453902", "R-HSA-5365859", "R-HSA-6785807", "R-GGA-2453902", "R-CFA-2162123", "R-RNO-163560", "R-MMU-5365859", "R-MMU-6798695", "R-RNO-6798695", "R-MMU-114608", "R-RNO-5362517", "R-BTA-5365859", "R-HSA-9725554", "R-MMU-6799990", "R-HSA-9918449", "R-RNO-6799990", "R-MMU-166665", "R-RNO-114608", "R-HSA-114608", "R-MMU-917937", "R-HSA-977606", "R-RNO-975634", "R-HSA-9029569", "R-HSA-5362517", "R-RNO-804914", "R-HSA-2162123", "R-CEL-163560", "R-HSA-9013508", "R-MMU-977606", "R-MMU-2162123", "R-CEL-189483", "R-HSA-381340", "R-SSC-804914", "R-RNO-2453902", "R-CEL-975634", "R-BTA-163560", "R-HSA-163560", "R-SSC-163560", "R-MMU-804914", "R-HSA-917937", "R-MMU-5362517", "R-CEL-400206", "R-HSA-975634", "R-HSA-2453902"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-804914:r:Transport of fatty acids", "R-CEL-5365859:r:RA biosynthesis pathway", "R-GGA-975634:r:Retinoid metabolism and transport", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-BTA-5362517:r:Signaling by Retinoic Acid", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-975634:r:Retinoid metabolism and transport", "R-BTA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-6799990:r:Metal sequestration by antimicrobial proteins", "R-CEL-159418:r:Recycling of bile acids and salts", "R-MMU-163560:r:Triglyceride catabolism", "R-HSA-9918442:r:Defective visual phototransduction due to LRAT loss of function", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-RNO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-RNO-5365859:r:RA biosynthesis pathway", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-6809583:r:Retinoid metabolism disease events", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-CEL-5362517:r:Signaling by Retinoic Acid", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-5365859:r:RA biosynthesis pathway", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CFA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-RNO-163560:r:Triglyceride catabolism", "R-MMU-5365859:r:RA biosynthesis pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation", "R-RNO-5362517:r:Signaling by Retinoic Acid", "R-BTA-5365859:r:RA biosynthesis pathway", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-MMU-6799990:r:Metal sequestration by antimicrobial proteins", "R-HSA-9918449:r:Defective visual phototransduction due to STRA6 loss of function", "R-RNO-6799990:r:Metal sequestration by antimicrobial proteins", "R-MMU-166665:r:Terminal pathway of complement", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-MMU-917937:r:Iron uptake and transport", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-RNO-804914:r:Transport of fatty acids", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-CEL-163560:r:Triglyceride catabolism", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-MMU-977606:r:Regulation of Complement cascade", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-CEL-189483:r:Heme degradation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SSC-804914:r:Transport of fatty acids", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CEL-975634:r:Retinoid metabolism and transport", "R-BTA-163560:r:Triglyceride catabolism", "R-HSA-163560:r:Triglyceride catabolism", "R-SSC-163560:r:Triglyceride catabolism", "R-MMU-804914:r:Transport of fatty acids", "R-HSA-917937:r:Iron uptake and transport", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-CEL-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Domain"}, "IPR000568": {"description": "ATP synthase, F0 complex, subunit A", "go_ids": ["GO:0045259", "GO:0015078", "GO:0015986"], "go_terms": ["GO:0045259:proton-transporting ATP synthase complex:C", "GO:0015078:proton transmembrane transporter activity:F", "GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_F0_asu", "pathway_ids": ["R-MMU-9837999", "R-HSA-5419276", "R-CEL-163210", "R-DME-8949613", "R-GGA-5419276", "R-RNO-5419276", "R-BTA-8949613", "R-BTA-9837999", "R-HSA-9837999", "R-RNO-163210", "R-DRE-8949613", "R-GGA-163210", "R-MMU-8949613", "R-GGA-8949613", "R-DRE-5419276", "R-SSC-163210", "R-DDI-9837999", "R-CEL-9837999", "R-SSC-8949613", "R-SSC-5419276", "R-DME-9837999", "R-MMU-163210", "R-DME-163210", "R-CEL-8949613", "R-RNO-9837999", "R-HSA-8949613", "R-HSA-163210", "R-DRE-9837999", "R-SPO-9837999", "R-SCE-9837999", "R-GGA-9837999", "R-MMU-5419276", "R-DME-5419276", "R-BTA-163210", "R-BTA-5419276", "R-CEL-5419276", "R-SSC-9837999", "R-RNO-8949613", "R-DRE-163210"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-CEL-163210:r:Formation of ATP by 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"R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-GGA-9837999:r:Mitochondrial protein degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-RNO-8949613:r:Cristae formation", "R-DRE-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR000569": {"description": "HECT domain", "go_ids": ["GO:0004842"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F"], "name": "HECT_dom", "pathway_ids": ["PWY-7511", "R-MMU-2173795", "R-BTA-983168", "R-HSA-9013409", "R-HSA-6798695", "R-MMU-5632684", "R-RNO-8948751", "R-HSA-168638", "R-MMU-8941858", "R-HSA-9833482", "R-CEL-1253288", "R-HSA-5689880", "R-DME-2173788", "R-MMU-2173791", "R-MMU-2122948", "R-HSA-5693565", "R-MMU-8948751", "R-DME-8948751", "R-DRE-8941858", "R-MMU-69473", "R-MMU-5689880", "R-HSA-5693607", "R-MMU-9013420", "R-HSA-4641257", "R-DME-8948747", "R-SCE-9013420", "R-HSA-9013507", "R-DME-4608870", "R-DRE-201451", "R-DME-4641257", "R-CEL-4641258", "R-HSA-69473", "R-HSA-5675482", "R-HSA-8941858", "R-MMU-8948747", "R-DME-1253288", "R-HSA-162588", "R-HSA-4641258", "R-DME-2173791", "R-MMU-4641258", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-9013406", "R-HSA-1253288", "R-HSA-8948751", "R-MMU-6798695", "R-CEL-8948751", "R-MMU-3108214", "R-MMU-2173788", "R-DRE-4608870", "R-RNO-983168", "R-DME-201451", "R-MMU-5693571", "R-RNO-6798695", 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"R-HSA-2173788", "R-HSA-8939236", "R-DME-5689880", "R-DME-9013420", "R-MMU-1253288"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9833482:r:PKR-mediated signaling", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-5693565:r:Recruitment and ATM-mediated 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"R-MMU-8948747:r:Regulation of PTEN localization", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-4641258:r:Degradation of DVL", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-201451:r:Signaling by BMP", 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"R-CEL-9013406:r:RHOQ GTPase cycle", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-RNO-8948747:r:Regulation of PTEN localization", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DME-5632684:r:Hedgehog 'on' state", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-9013420:r:RHOU GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-1253288:r:Downregulation of ERBB4 signaling"], "type": "Domain"}, "IPR000571": {"description": "Zinc finger, CCCH-type", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Znf_CCCH", "pathway_ids": ["R-HSA-180910", "R-HSA-6807505", "R-HSA-6802952", "R-MMU-9770562", "R-GGA-73856", "R-MMU-198323", "R-CEL-450385", "R-MMU-4570464", "R-HSA-73856", "R-XTR-159236", "R-RNO-72163", "R-RNO-450513", "R-HSA-170822", "R-SPO-9930044", "R-MMU-8948751", "R-HSA-9834752", "R-SCE-198323", "R-RNO-73856", "R-MMU-4551638", "R-HSA-9828806", "R-RNO-450385", "R-HSA-4570464", "R-DRE-9629569", "R-DME-73856", "R-SPO-4085377", "R-BTA-72163", "R-MMU-9930044", "R-DRE-8948751", "R-SPO-159236", "R-HSA-429947", "R-SCE-77595", "R-MMU-72163", "R-MMU-3301854", "R-HSA-168315", "R-XTR-4085377", "R-MMU-170822", "R-HSA-9609690", "R-CEL-450513", "R-DRE-3371453", "R-HSA-159231", "R-HSA-3232142", "R-HSA-9828721", "R-HSA-72163", "R-HSA-9820960", "R-MMU-159227", "R-DRE-159227", "R-HSA-9820841", "R-CEL-8948751", "R-MMU-3108214", "R-XTR-9629569", "R-XTR-3108214", "R-BTA-9629569", "R-SCE-429947", "R-DME-983168", "R-SPO-3371453", "R-HSA-191859", "R-HSA-9705671", "R-SPO-159227", "R-MMU-3232142", "R-XTR-9770562", "R-MMU-77595", "R-RNO-77595", "R-RNO-9930044", "R-CEL-983168", "R-DRE-191859", "R-HSA-159227", "R-DRE-983168", "R-HSA-77595", "R-DRE-72163", "R-DRE-3108214", "R-DME-9770562", "R-MMU-429947", "R-HSA-6782315", "R-HSA-165054", "R-XTR-77595", "R-RNO-159236", "R-HSA-72165", "R-HSA-4615885", "R-CEL-72163", "R-MMU-191859", "R-MMU-159231", "R-MMU-3371453", "R-XTR-191859", "R-HSA-9770562", "R-HSA-9828642", "R-HSA-168271", "R-BTA-72165", "R-DDI-9629569", "R-SPO-4551638", "R-HSA-381340", "R-XTR-3371453", "R-HSA-9707616", "R-PFA-72163", "R-HSA-450385", "R-MMU-9629569", "R-MMU-450513", "R-MMU-72187", "R-MMU-72165", "R-DME-450513", "R-RNO-159231", "R-HSA-450513", "R-RNO-9770562", "R-HSA-180746", "R-CEL-198323", "R-HSA-2426168", "R-DRE-72165", "R-RNO-9629569", "R-HSA-1989781", "R-XTR-4615885", "R-HSA-6804115", "R-HSA-2151201", "R-DRE-3232142", "R-DRE-4551638", "R-HSA-72187", 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Synthesis", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-SPO-8948751:r:Regulation of PTEN stability and activity", "R-SPO-429947:r:Deadenylation of mRNA", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9833110:r:RSV-host interactions", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript"], "type": "Domain"}, "IPR000572": {"description": "Oxidoreductase, molybdopterin-binding domain", "go_ids": [], "go_terms": [], "name": "OxRdtase_Mopterin-bd_dom", "pathway_ids": ["R-MMU-1614517", "R-HSA-1614517", "R-DME-1614517", "R-RNO-1614517"], "pathways": ["R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-HSA-1614517:r:Sulfide oxidation to sulfate", "R-DME-1614517:r:Sulfide oxidation to sulfate", "R-RNO-1614517:r:Sulfide oxidation to sulfate"], "type": "Domain"}, "IPR000573": {"description": "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain", "go_ids": [], "go_terms": [], "name": "AconitaseA/IPMdHydase_ssu_swvl", "pathway_ids": ["R-DDI-9837999", "R-MMU-71403", "R-CEL-917937", "R-HSA-9854311", "R-CEL-389542", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-9854311", "R-SPO-9854311", "R-BTA-71403", "R-DDI-917937", "R-RNO-917937", "R-MMU-389542", "R-RNO-9837999", "R-RNO-389542", "R-MMU-917937", "R-RNO-9854311", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-CEL-9854311", "R-SPO-9837999", "R-HSA-917937", "R-BTA-9837999", "R-SCE-71403", "R-SCE-9837999", "R-SSC-917937", "R-HSA-389542", "R-DDI-9854311", "R-DDI-71403", "R-HSA-1268020", "R-HSA-9837999", "R-RNO-71403", "R-DDI-389542", "R-HSA-71403", "R-SCE-9854311"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-389542:r:NADPH regeneration", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-917937:r:Iron uptake and transport", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-389542:r:NADPH regeneration", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-389542:r:NADPH regeneration", "R-MMU-917937:r:Iron uptake and transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-917937:r:Iron uptake and transport", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-SSC-917937:r:Iron uptake and transport", "R-HSA-389542:r:NADPH regeneration", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-389542:r:NADPH regeneration", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Domain"}, "IPR000574": {"description": "Tymovirus coat protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Tymo_coat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000576": {"description": "LacY/RafB permease family", "go_ids": ["GO:0016020", "GO:0005351", "GO:0008643"], "go_terms": ["GO:0016020:membrane:C", "GO:0005351:carbohydrate:proton symporter activity:F", "GO:0008643:carbohydrate transport:P"], "name": "LacY/RafB_perm_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000577": {"description": "Carbohydrate kinase, FGGY", "go_ids": ["GO:0016301", "GO:0005975"], "go_terms": ["GO:0016301:kinase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Carb_kinase_FGGY", "pathway_ids": ["PWY-4261", "R-HSA-5661270", "R-RNO-5661270", "R-BTA-75109", "R-DDI-75109", "R-BTA-5661270", "R-MMU-75109", "R-CEL-75109", "R-MMU-5661270", "R-HSA-75109", "R-RNO-75109", "R-CEL-5661270"], "pathways": ["PWY-4261:t:glycerol degradation I", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-BTA-75109:r:Triglyceride biosynthesis", "R-DDI-75109:r:Triglyceride biosynthesis", "R-BTA-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-75109:r:Triglyceride biosynthesis", "R-CEL-75109:r:Triglyceride biosynthesis", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-75109:r:Triglyceride biosynthesis", "R-RNO-75109:r:Triglyceride biosynthesis", "R-CEL-5661270:r:Formation of xylulose-5-phosphate"], "type": "Family"}, "IPR000580": {"description": "TSC22/Bun", "go_ids": ["GO:0006357"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "TSC22/Bun", "pathway_ids": ["R-CEL-2672351", "R-HSA-2672351", "R-RNO-2672351", "R-MMU-2672351"], "pathways": ["R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-RNO-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR000581": {"description": "Dihydroxy-acid/6-phosphogluconate dehydratase, N-terminal", "go_ids": [], "go_terms": [], "name": "ILV_EDD_N", "pathway_ids": ["PWY-7111", "PWY-5101", "PWY-5103", "PWY-5104"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-5103:t:L-isoleucine biosynthesis III", "PWY-5104:t:L-isoleucine biosynthesis IV"], "type": "Domain"}, "IPR000582": {"description": "Acyl-CoA-binding protein, ACBP", "go_ids": ["GO:0000062"], "go_terms": ["GO:0000062:fatty-acyl-CoA binding:F"], "name": "Acyl-CoA-binding_protein", "pathway_ids": ["R-XTR-9013106", "R-CEL-390918", "R-BTA-390918", "R-MMU-9013106", "R-RNO-390918", "R-MMU-8980692", "R-RNO-9603798", "R-RNO-8980692", "R-MMU-432722", "R-CEL-77289", "R-CFA-77289", "R-HSA-9013106", "R-RNO-9033241", "R-DRE-77289", "R-DRE-390918", "R-RNO-77289", "R-RNO-9013106", "R-MMU-9603798", "R-HSA-432722", "R-HSA-9603798", "R-RNO-432722", "R-HSA-77289", "R-DRE-9013106", "R-DME-77289", "R-BTA-77289", "R-MMU-9033241", "R-DDI-77289", "R-SCE-77289", "R-DRE-9603798", "R-HSA-390918", "R-MMU-390918", "R-XTR-8980692", "R-XTR-9603798", "R-HSA-8980692", "R-HSA-390247", "R-MMU-77289", "R-MMU-390247", "R-DRE-8980692", "R-SPO-77289", "R-XTR-390918", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-XTR-9013106:r:RHOC GTPase cycle", "R-CEL-390918:r:Peroxisomal lipid metabolism", "R-BTA-390918:r:Peroxisomal lipid metabolism", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-390918:r:Peroxisomal lipid metabolism", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-CFA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9013106:r:RHOC GTPase cycle", "R-RNO-9033241:r:Peroxisomal protein import", "R-DRE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DRE-390918:r:Peroxisomal lipid metabolism", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DRE-9013106:r:RHOC GTPase cycle", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SCE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DRE-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-MMU-390918:r:Peroxisomal lipid metabolism", "R-XTR-8980692:r:RHOA GTPase cycle", "R-XTR-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-DRE-8980692:r:RHOA GTPase cycle", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-XTR-390918:r:Peroxisomal lipid metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR000587": {"description": "Creatinase, N-terminal", "go_ids": [], "go_terms": [], "name": "Creatinase_N", "pathway_ids": ["R-DDI-163125", "R-MMU-163125", "R-SCE-163125", "R-RNO-163125", "R-HSA-163125"], "pathways": ["R-DDI-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-SCE-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Domain"}, "IPR000588": {"description": "Peptidase A3A, cauliflower mosaic virus-type", "go_ids": ["GO:0004190", "GO:0006508"], "go_terms": ["GO:0004190:aspartic-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_A3A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000589": {"description": "Small ribosomal subunit protein uS15", 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recognition", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "type": "Family"}, "IPR000591": {"description": "DEP domain", "go_ids": ["GO:0035556"], "go_terms": ["GO:0035556:intracellular signal transduction:P"], "name": "DEP_dom", "pathway_ids": ["R-HSA-9013409", "R-MMU-8856828", "R-HSA-9013405", "R-XTR-8856825", "R-MMU-9013408", "R-MMU-9013409", "R-XTR-4641262", "R-MMU-8948751", "R-HSA-9639288", "R-CFA-114608", "R-MMU-9013420", "R-DME-350411", "R-RNO-4641258", "R-MMU-9035034", "R-DME-350369", "R-RNO-4086400", "R-MMU-392517", "R-MMU-4086400", "R-DDI-5673001", "R-HSA-416482", "R-RNO-5663220", "R-HSA-9696264", "R-MMU-9013423", "R-MMU-4641258", "R-XTR-4086400", "R-MMU-4641262", "R-MMU-193648", "R-HSA-9013026", "R-MMU-9696264", "R-CEL-8856825", "R-MMU-354192", "R-HSA-392517", "R-MMU-5663220", "R-HSA-201681", "R-RNO-4641262", "R-MMU-8980692", "R-HSA-9013106", "R-DME-2028269", "R-MMU-418594", "R-RNO-418594", "R-HSA-9013423", "R-HSA-114608", "R-SCE-418594", "R-RNO-354192", "R-CEL-354192", "R-HSA-9013148", "R-HSA-4641262", "R-CEL-9013406", "R-BTA-6814122", "R-CEL-9013423", "R-CEL-8856828", "R-DDI-9639288", "R-HSA-9696270", "R-DDI-392517", "R-XTR-201688", "R-HSA-5099900", "R-MMU-9013424", "R-DME-350480", "R-CEL-201688", "R-RNO-422356", "R-HSA-8856825", "R-CEL-9013420", "R-RNO-6814122", "R-HSA-5663220", "R-HSA-6814122", "R-MMU-9696273", "R-MMU-9013149", "R-HSA-422356", "R-DDI-354192", "R-CEL-8980692", "R-MMU-9013106", "R-MMU-1660516", "R-HSA-8856828", "R-CEL-5099900", "R-MMU-5099900", "R-MMU-9639288", "R-CEL-9013424", "R-CEL-9013409", "R-MMU-9013404", "R-HSA-9013424", "R-DME-4086400", "R-DME-350376", "R-CEL-9035034", "R-MMU-381676", "R-DME-5099900", "R-RNO-392517", "R-BTA-418594", "R-DME-4641262", "R-XTR-5099900", "R-MMU-1660514", "R-DDI-9013423", "R-DME-5663220", "R-DME-4608870", "R-HSA-9013408", "R-CEL-9013148", "R-DDI-193648", "R-CEL-4641258", "R-HSA-2514859", "R-CEL-4086400", "R-XTR-4641258", "R-HSA-4641258", "R-HSA-1660516", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-4608870", "R-HSA-381676", "R-MMU-9013406", "R-HSA-8948751", "R-MMU-1660517", "R-RNO-2514859", "R-XTR-2028269", "R-MMU-114608", "R-RNO-201688", "R-HSA-1660517", "R-CEL-5663220", "R-MMU-8856825", "R-MMU-422356", "R-HSA-5368598", "R-DME-4641258", "R-DME-350368", "R-MMU-201688", "R-MMU-9013148", "R-CEL-6814122", "R-CEL-9013149", "R-RNO-114608", "R-DDI-9013149", "R-DDI-381676", "R-HSA-9035034", "R-MMU-2514859", "R-MMU-4608870", "R-DME-450728", "R-HSA-354192", "R-MMU-6814122", "R-XTR-8856828", "R-HSA-193648", "R-HSA-201688", "R-DDI-171007", "R-HSA-9013420", "R-MMU-2028269", "R-CEL-392517", "R-HSA-4086400", "R-XTR-5663220", "R-RNO-381676", "R-HSA-9673324", "R-CEL-418594", "R-CEL-381676", "R-HSA-1660514", "R-DME-201688", "R-HSA-418594", "R-CEL-2028269", "R-DME-209440", "R-MMU-9013026", "R-MMU-416482", "R-SPO-418594", "R-HSA-9013406", "R-MMU-9696270", "R-DDI-1169092", "R-HSA-2028269", "R-HSA-9696273"], "pathways": ["R-HSA-9013409:r:RHOJ 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Formins", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-4641258:r:Degradation of DVL", "R-XTR-4086400:r:PCP/CE pathway", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-354192:r:Integrin signaling", "R-HSA-392517:r:Rap1 signalling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DME-2028269:r:Signaling by Hippo", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-114608:r:Platelet 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"R-CEL-9035034:r:RHOF GTPase cycle", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-392517:r:Rap1 signalling", "R-BTA-418594:r:G alpha (i) signalling events", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-DDI-193648:r:NRAGE signals death through JNK", "R-CEL-4641258:r:Degradation of DVL", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-4086400:r:PCP/CE pathway", "R-XTR-4641258:r:Degradation of DVL", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-XTR-2028269:r:Signaling by Hippo", "R-MMU-114608:r:Platelet degranulation", "R-RNO-201688:r:WNT mediated activation of DVL", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-422356:r:Regulation of insulin secretion", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-DME-4641258:r:Degradation of DVL", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-MMU-201688:r:WNT mediated activation of DVL", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-HSA-354192:r:Integrin signaling", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-201688:r:WNT mediated activation of DVL", "R-DDI-171007:r:p38MAPK events", "R-HSA-9013420:r:RHOU GTPase cycle", "R-MMU-2028269:r:Signaling by Hippo", "R-CEL-392517:r:Rap1 signalling", "R-HSA-4086400:r:PCP/CE pathway", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-CEL-418594:r:G alpha (i) signalling events", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-201688:r:WNT mediated activation of DVL", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-2028269:r:Signaling by Hippo", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-SPO-418594:r:G alpha (i) signalling events", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DDI-1169092:r:Activation of RAS in B cells", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR000592": {"description": "Small ribosomal subunit protein eS27", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eS27", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-MMU-2467813", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-MMU-68877", "R-RNO-1799339", "R-HSA-72695", "R-RNO-72695", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-CEL-72706", "R-BTA-2500257", "R-BTA-72695", "R-CEL-9954714", "R-CEL-9954716", "R-SCE-72702", "R-BTA-141444", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-BTA-156827", "R-MMU-6791226", "R-MMU-141444", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-DDI-72695", "R-CEL-1799339", "R-BTA-72702", "R-HSA-141444", "R-HSA-72706", "R-HSA-9648025", "R-HSA-9735869", "R-HSA-72702", "R-RNO-5663220", "R-CEL-156827", "R-RNO-6791226", "R-RNO-72649", "R-HSA-6791226", "R-RNO-975956", "R-CEL-72649", "R-SPO-156827", "R-RNO-2467813", "R-HSA-9954714", "R-BTA-9648025", "R-BTA-72649", "R-SPO-72689", "R-MMU-5663220", "R-MMU-1799339", "R-RNO-141444", "R-DDI-72702", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DDI-72689", "R-CEL-72689", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-BTA-5663220", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-2467813", "R-BTA-72706", "R-SCE-975957", "R-HSA-68877", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-MMU-9648025", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-MMU-2500257", "R-SCE-156827", "R-MMU-72702", "R-RNO-68877", "R-HSA-2500257", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-HSA-9754678", "R-HSA-72649", "R-BTA-1799339", "R-MMU-156827", "R-BTA-9954714", "R-SCE-72649", "R-HSA-975957", "R-BTA-975956", "R-HSA-5663220", "R-RNO-9648025", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-1799339:r:SRP-dependent 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"R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000593": {"description": "IQGAP, helical domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "IQGAP_helical", "pathway_ids": ["R-HSA-6798695", "R-HSA-9013409", "R-SPO-6798695", "R-HSA-5674135", "R-MMU-5674135", "R-HSA-6802952", "R-HSA-5626467", "R-MMU-9013106", "R-MMU-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-HSA-9013106", "R-HSA-9013424", "R-MMU-9013404", "R-DDI-5626467", "R-DDI-9013149", "R-SPO-9013106", "R-SPO-9013406", "R-SCE-5626467", "R-MMU-9013420", "R-SCE-9013406", "R-SCE-8980692", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-9013148", "R-SCE-9013420", "R-SPO-9013420", "R-HSA-9013408", "R-SCE-9013424", "R-HSA-6802955", "R-SPO-5626467", "R-HSA-373753", "R-DDI-6798695", "R-HSA-9013420", "R-HSA-6802948", "R-MMU-5626467", "R-MMU-9013424", "R-SCE-9013106", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-373753", "R-HSA-9013149", "R-HSA-8980692", "R-DDI-5674135", "R-HSA-381676", "R-MMU-9013406", "R-SPO-9013424", "R-HSA-9013026", "R-MMU-6798695", "R-DDI-9013404", "R-HSA-9013406", "R-MMU-9013149", "R-HSA-9656223"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-SPO-9013106:r:RHOC GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-SCE-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SCE-9013420:r:RHOU GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SPO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-373753:r:Nephrin family interactions", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SCE-9013106:r:RHOC GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-373753:r:Nephrin family interactions", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-9013424:r:RHOV GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Domain"}, "IPR000594": {"description": "THIF-type NAD/FAD binding fold", "go_ids": [], "go_terms": [], "name": "ThiF_NAD_FAD-bd", "pathway_ids": ["R-BTA-983168", "R-HSA-6798695", "R-MMU-9909505", "R-GGA-1632852", "R-HSA-6802952", "R-HSA-8951664", "R-HSA-3065678", "R-MMU-1632852", "R-HSA-9918485", "R-HSA-5676590", "R-MMU-8866652", "R-SCE-3065678", "R-CEL-947581", "R-SPO-3065678", "R-SPO-947581", "R-DME-947581", "R-RNO-1632852", "R-HSA-8866652", "R-SSC-947581", "R-RNO-5607761", "R-BTA-3065678", "R-DDI-6798695", "R-SPO-3065676", "R-HSA-5607761", "R-MMU-3065676", "R-CEL-3065678", "R-GGA-6798695", "R-DRE-3065676", "R-SCE-1632852", "R-DRE-947581", "R-BTA-8866652", "R-HSA-1632852", "R-MMU-6798695", "R-CEL-3065676", "R-RNO-983168", "R-SPO-1632852", 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"R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000600": {"description": "ROK family", "go_ids": [], "go_terms": [], "name": "ROK", "pathway_ids": ["R-HSA-4085001", "R-HSA-4085011", "R-MMU-4085001", "R-RNO-4085001"], "pathways": ["R-HSA-4085001:r:Sialic acid metabolism", "R-HSA-4085011:r:Defective GNE causes sialuria, NK and IBM2", "R-MMU-4085001:r:Sialic acid metabolism", "R-RNO-4085001:r:Sialic acid metabolism"], "type": "Family"}, "IPR000601": {"description": "PKD domain", "go_ids": [], "go_terms": [], "name": "PKD_dom", "pathway_ids": ["R-MMU-8856828", "R-HSA-5620916", "R-MMU-5620916", "R-MMU-8857538", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-RNO-8857538", "R-HSA-9824585", "R-HSA-8857538"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Domain"}, "IPR000602": {"description": "Glycoside hydrolase family 38, N-terminal domain", "go_ids": ["GO:0006013", "GO:0004559"], "go_terms": ["GO:0006013:mannose metabolic process:P", "GO:0004559:alpha-mannosidase activity:F"], "name": "Glyco_hydro_38_N", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-MMU-8853383", "R-RNO-8853383", "R-BTA-8853383", "R-HSA-6811438", "R-DME-975578", "R-HSA-975578", "R-HSA-8853383", "R-HSA-9694548", "R-SPO-8853383", "R-MMU-6798695", "R-RNO-975578", "R-BTA-6798695", "R-MMU-975578", "R-DDI-8853383", "R-SCE-8853383"], "pathways": ["R-HSA-6798695:r:Neutrophil 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"R-DME-2559582", "R-MMU-68867", "R-MMU-975144", "R-RNO-176412", "R-DME-174048", "R-CEL-4085377", "R-DME-141430", "R-RNO-174048", "R-HSA-69473", "R-DME-209461", "R-DDI-4570464", "R-CEL-3065678", "R-MMU-2559582", "R-MMU-450321", "R-RNO-5693571", "R-HSA-6783310", "R-DDI-4615885", "R-RNO-179409", "R-MMU-9646399", "R-GGA-5693571", "R-HSA-9615933", "R-RNO-4085377", "R-DRE-196791", "R-RNO-8951664", "R-SPO-110314", "R-HSA-5696395", "R-BTA-8866654", "R-CEL-5696395", "R-HSA-174048", "R-DME-1234176", "R-GGA-8866904", "R-DME-201451", "R-DDI-3899300", "R-DDI-3108214", "R-DME-69017", "R-SCE-3108214", "R-DME-983168", "R-HSA-9954716", "R-SCE-4615885", "R-RNO-4615885", "R-SPO-4615885", "R-HSA-2467813", "R-SCE-4570464", "R-HSA-168928", "R-HSA-9705671", "R-GGA-983168", "R-GGA-4090294", "R-GGA-9856649", "R-MMU-179409", "R-BTA-176412", "R-RNO-8866652", "R-BTA-201451", "R-RNO-1169408", "R-GGA-8951664", "R-CEL-3899300", "R-CEL-983168", "R-DME-8866652", "R-DME-937039", "R-DRE-3108214", "R-HSA-5357905", "R-DRE-2559582", "R-GGA-4755510", "R-DRE-8866652", "R-RNO-9793242", "R-DDI-2467813", "R-DDI-176412", "R-BTA-174184", "R-GGA-3065678", "R-MMU-4090294", "R-DRE-176408", "R-SCE-3232118", "R-XTR-8866652", "R-MMU-202424", "R-MMU-5693607", "R-HSA-176412", "R-BTA-9705462", "R-MMU-176408", "R-DME-209360", "R-XTR-4090294", "R-DME-5357905", "R-DME-8866654", "R-BTA-9954716", "R-DRE-174154", "R-RNO-9856649", "R-XTR-3232118", "R-DME-176412", "R-DME-9646399", "R-MMU-5607761", "R-CEL-9615933", "R-DRE-3899300", "R-DME-445989", "R-SPO-9033241", "R-HSA-5693571", "R-GGA-4655427", "R-DDI-174184", "R-DRE-4090294", "R-DME-174178", "R-DDI-9609523", "R-DRE-179409", "R-RNO-9646399", "R-BTA-5693571", "R-CEL-9020702", "R-BTA-983168", "R-MMU-5607764", "R-HSA-9700645", "R-BTA-179409", "R-DME-8951664", "R-BTA-141430", "R-DRE-8951664", "R-DDI-9646399", "R-HSA-5676590", "R-BTA-2173789", "R-DME-9954716", "R-XTR-4570464", "R-DDI-9020702", "R-RNO-2173795", "R-HSA-141430", "R-XTR-4551638", "R-CEL-9909505", "R-HSA-8866652", "R-RNO-9954716", "R-RNO-8866904", "R-MMU-9833482", "R-MMU-4655427", "R-DDI-2559582", "R-RNO-202424", "R-MMU-3232118", "R-GGA-5693565", "R-SCE-3899300", "R-CEL-9856649", "R-HSA-9609523", "R-HSA-4551638", "R-HSA-176408", "R-HSA-2173789", "R-RNO-3899300", "R-HSA-68867", "R-HSA-176409", "R-DME-174154", "R-HSA-975144", "R-CEL-3232118", "R-DME-179409", "R-CEL-9833482", "R-MMU-9705462", "R-HSA-9694631", "R-CEL-9793242", "R-SPO-4570464", "R-MMU-141430", "R-MMU-2871837", "R-RNO-174084", "R-RNO-445989", "R-GGA-3232118", "R-RNO-5689896", "R-MMU-9793242", "R-RNO-983168", "R-DRE-176412", "R-HSA-445989", "R-HSA-110314", "R-HSA-8853884", "R-GGA-3899300", "R-BTA-8951664", "R-SPO-176408", "R-GGA-3108214", "R-DRE-4615885", "R-RNO-9909505", "R-HSA-936440", "R-GGA-4551638", "R-HSA-2559582", "R-HSA-1169408", "R-HSA-174184", "R-CEL-5205685", "R-MMU-174048", "R-HSA-9909505", "R-MMU-4615885", "R-GGA-9793242", "R-DRE-8866654", "R-BTA-2467813", "R-CEL-936440", "R-HSA-9954709", "R-SPO-983168", "R-HSA-9833110", "R-BTA-5696395", "R-HSA-5656169", "R-BTA-168638", "R-HSA-5607764", "R-HSA-9918481", "R-MMU-3065678", "R-DDI-1169408", "R-SPO-3108214", "R-DRE-5693565", "R-BTA-5689896", "R-CEL-9954709", "R-DME-9033241", "R-BTA-174048", "R-DRE-4755510", "R-DRE-174084", "R-RNO-4755510", "R-MMU-176407", "R-RNO-4655427", "R-DDI-983168", "R-XTR-196791", "R-DDI-9909505", "R-DME-5205685", "R-BTA-450302", "R-SPO-9609523", "R-HSA-9705462", "R-MMU-983168", "R-DDI-174178", "R-DDI-9954716", "R-DME-68867"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-GGA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9646399:r:Aggrephagy", "R-DME-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8951664:r:Neddylation", "R-DRE-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-5357905:r:Regulation of TNFR1 signaling", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-SCE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-3232118:r:SUMOylation of transcription factors", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-433871:r:TRAF6 mediated induction of proinflammatory cytokines", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DRE-9793242:r:SUMOylation of nuclear envelope proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CEL-4090294:r:SUMOylation of intracellular receptors", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-3232118:r:SUMOylation of transcription factors", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-XTR-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-DME-202424:r:Downstream TCR signaling", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-DRE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-HSA-201451:r:Signaling by BMP", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-XTR-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DRE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-201451:r:Signaling by BMP", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", 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"R-BTA-4641258", "R-MMU-1799339", "R-MMU-5610780", "R-CEL-8863795", "R-HSA-3108214", "R-DDI-75815", "R-CFA-9758274", "R-GGA-174113", "R-BTA-6807004", "R-BTA-174178", "R-BTA-3769402", "R-CFA-8948747", "R-CFA-937039", "R-HSA-2173791", "R-SSC-975956", "R-GGA-434001", "R-CFA-9931295", "R-BTA-8854050", "R-SSC-8866654", "R-BTA-5607764", "R-SSC-9664873", "R-SSC-1253288", "R-GGA-75815", "R-CFA-1169091", "R-CEL-5632684", "R-HSA-5689880", "R-CFA-8863795", "R-SSC-6782210", "R-DME-5654732", "R-MMU-4551638", "R-DME-1295596", "R-CFA-5689603", "R-HSA-1234176", "R-MMU-68867", "R-DME-2559582", "R-BTA-182971", "R-MMU-72163", "R-BTA-6782135", "R-DME-209461", "R-BTA-2173788", "R-HSA-6804760", "R-HSA-72702", "R-GGA-937072", "R-GGA-9013507", "R-CFA-5655862", "R-CFA-6781823", "R-SSC-5654733", "R-BTA-917937", "R-CEL-5696395", "R-HSA-5696394", "R-CFA-5610785", "R-DME-69017", "R-RNO-5676590", "R-RNO-69601", "R-SSC-349425", "R-SSC-9931295", "R-CEL-75815", "R-CFA-936964", "R-CFA-5357956", "R-SCE-3232118", "R-MMU-72695", "R-DME-209360", "R-CFA-975163", "R-RNO-9856649", "R-HSA-72649", "R-SSC-202424", "R-DRE-4090294", "R-GGA-1169091", "R-CFA-445989", "R-HSA-5696400", "R-CEL-9020702", "R-DDI-8854050", "R-CFA-9931269", "R-GGA-5358346", "R-HSA-5676590", "R-DME-9954716", "R-CFA-174048", "R-DDI-9020702", "R-SSC-5684264", "R-HSA-174490", "R-MMU-975163", "R-RNO-5607761", "R-HSA-4551638", "R-HSA-1799339", "R-CEL-4641258", "R-GGA-8849469", "R-DME-5689877", "R-SSC-69601", "R-DME-2173791", "R-GGA-8948747", "R-RNO-532668", "R-HSA-9613829", "R-DDI-5689877", "R-RNO-2122948", "R-HSA-110314", "R-GGA-3899300", "R-HSA-5689901", "R-SSC-8866652", "R-HSA-187577", "R-HSA-209543", "R-GGA-4641258", "R-DDI-9770562", "R-SSC-8951664", "R-DME-195253", "R-CFA-110312", "R-HSA-1236382", "R-DME-110312", "R-HSA-5656169", "R-HSA-937072", "R-HSA-5607764", "R-CFA-5696395", "R-MMU-1358803", "R-MMU-3769402", "R-SPO-3108214", "R-BTA-2173791", "R-SSC-8852276", "R-DME-538864", "R-GGA-2173791", "R-CEL-68949", "R-HSA-5687128", 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"R-MMU-445989", "R-RNO-174154", "R-CEL-5689603", "R-SSC-3108214", "R-CFA-1234176", "R-HSA-69481", "R-GGA-9824878", "R-DRE-8866904", "R-HSA-5357786", "R-SPO-5689603", "R-HSA-5602636", "R-RNO-2173791", "R-HSA-180585", "R-RNO-168638", "R-DRE-5693565", "R-DME-5607764", "R-SSC-5654727", "R-RNO-2559585", "R-GGA-351465", "R-BTA-382556", "R-MMU-9648002", "R-CEL-9646399", "R-GGA-174154", "R-MMU-4085377", "R-SSC-937072", "R-SSC-9931269", "R-GGA-2467813", "R-HSA-5334118", "R-DME-975144", "R-DDI-9861718", "R-GGA-6804757", "R-HSA-4085377", "R-SSC-4641258", "R-MMU-9033241", "R-BTA-5689603", "R-SSC-8856828", "R-HSA-917937", "R-CFA-6804756", "R-CFA-450302", "R-DME-975163", "R-DME-110314", "R-MMU-9909505", "R-RNO-8948751", "R-CEL-195253", "R-MMU-8866652", "R-MMU-9615933", "R-GGA-1358803", "R-RNO-5656169", "R-DDI-9033241", "R-BTA-72163", "R-GGA-4570464", "R-CEL-8866652", "R-RNO-8983711", "R-HSA-5654727", "R-SSC-9954714", "R-SSC-5675482", "R-BTA-4551638", "R-HSA-6783310", "R-DME-5675221", "R-SSC-1799339", "R-RNO-4085377", "R-HSA-1295596", "R-DRE-196791", "R-RNO-8951664", "R-GGA-195253", "R-HSA-9648002", "R-RNO-5358346", "R-BTA-9833482", "R-RNO-2173796", "R-HSA-9954716", "R-MMU-72689", "R-GGA-4090294", "R-HSA-2672351", "R-RNO-69541", "R-MMU-6781823", "R-SSC-4085377", "R-GGA-8941858", "R-GGA-4755510", "R-SSC-3899300", "R-RNO-9793242", "R-GGA-9954714", "R-CFA-168638", "R-HSA-72165", "R-RNO-349425", "R-SSC-975163", "R-BTA-9954716", "R-MMU-9706369", "R-GGA-5696394", "R-DME-901032", "R-RNO-69231", "R-HSA-8939902", "R-MMU-5654726", "R-GGA-4655427", "R-DME-5696400", "R-HSA-877300", "R-CFA-3769402", "R-GGA-1799339", "R-RNO-6783310", "R-MMU-182971", "R-SSC-9033241", "R-GGA-1234176", "R-RNO-1799339", "R-HSA-5655862", "R-RNO-8866904", "R-MMU-9929491", "R-HSA-9609523", "R-GGA-3769402", "R-DME-174154", "R-BTA-450408", "R-DDI-72695", "R-CFA-2871837", "R-DME-2122948", "R-MMU-8856825", "R-HSA-349425", "R-BTA-8941858", "R-MMU-9010553", "R-DME-4641258", "R-HSA-936440", "R-HSA-2559582", "R-HSA-1169408", "R-CFA-5676590", "R-SSC-5689880", "R-DME-975956", "R-BTA-5689896", "R-HSA-382556", "R-HSA-6782135", "R-CFA-9929356", "R-SSC-5693565", "R-HSA-1810476", "R-CEL-69601", "R-DME-5205685", "R-GGA-182971", "R-RNO-9861718", "R-GGA-5689901", "R-HSA-9646399", "R-SSC-8948751", "R-BTA-9755511", "R-SSC-174184", "R-GGA-5675221", "R-HSA-8863795", "R-DME-5655862", "R-HSA-450302", "R-DDI-5689901", "R-BTA-110314", "R-GGA-1227892", "R-HSA-9931295", "R-CFA-5654732", "R-HSA-205043", "R-HSA-6804756", "R-CFA-8866654", "R-DDI-4641258", "R-RNO-4570464", "R-GGA-179409", "R-GGA-9646399", "R-RNO-174178", "R-MMU-174178", "R-XTR-5696395", "R-HSA-196791", "R-RNO-3065679", "R-DDI-1358803", "R-BTA-936440", "R-CFA-5693565", "R-BTA-445989", "R-DME-1799339", "R-CEL-3108214", "R-HSA-6782210", "R-GGA-1227882", "R-MMU-936964", "R-GGA-69601", "R-CFA-69231", "R-GGA-901032", "R-HSA-8866427", "R-MMU-5656121", "R-RNO-187577", "R-HSA-3065676", "R-CEL-75876", "R-DDI-975957", "R-RNO-69017", "R-RNO-72706", "R-BTA-9909505", "R-CEL-8948747", "R-SCE-9615933", "R-RNO-2559582", "R-SCE-5689603", "R-DRE-3232142", "R-DDI-937072", "R-CFA-4641258", "R-HSA-450321", "R-MMU-72706", "R-HSA-167246", "R-HSA-3371453", "R-RNO-205043", "R-BTA-9706369", "R-RNO-9929356", "R-BTA-8863795", "R-GGA-450302", "R-MMU-209543", "R-HSA-5678895", "R-BTA-1358803", "R-GGA-5656169", "R-BTA-8866652", "R-MMU-4641257", "R-SCE-8856825", "R-CFA-179409", "R-BTA-9770562", "R-MMU-3065679", "R-GGA-1253288", "R-MMU-2173788", "R-BTA-1169408", "R-CEL-5689896", "R-DME-9954709", "R-CFA-8866652", "R-SCE-9856649", "R-MMU-9755511", "R-BTA-937072", "R-SSC-4755510", "R-RNO-5689603", "R-RNO-8849469", "R-CFA-4608870", "R-RNO-937039", "R-DDI-69017", "R-MMU-5655862", "R-SSC-3232142", "R-RNO-9929491", "R-BTA-5205685", "R-HSA-2894862", "R-HSA-5632684", "R-SSC-2871837", "R-HSA-8876493", "R-RNO-5607764", "R-GGA-2672351", "R-HSA-9793242", "R-MMU-5654733", "R-SSC-5676590", "R-HSA-9843940", "R-GGA-937041", "R-SSC-937039", "R-BTA-1234176", "R-RNO-5693565", "R-CFA-69481", "R-RNO-5655862", "R-SSC-69231", "R-CFA-8939902", "R-RNO-5689901", "R-RNO-877312", "R-RNO-937042", "R-BTA-936964", "R-BTA-2173795", "R-SSC-110312", "R-BTA-5689901", "R-CEL-2173788", "R-HSA-9931269", "R-HSA-2408557", "R-MMU-3065676", "R-BTA-4755510", "R-SPO-5696394", "R-BTA-5684264", "R-BTA-5675221", "R-SCE-8951664", "R-GGA-209543", "R-DME-182971", "R-CFA-909733", "R-SCE-4615885", "R-DME-1358803", "R-SSC-2173795", "R-GGA-5610785", "R-DME-937039", "R-BTA-4090294", "R-RNO-4641257", "R-BTA-72706", "R-DDI-5689603", "R-SSC-9020702", "R-GGA-9033241", "R-MMU-877312", "R-MMU-202424", "R-BTA-5632684", "R-XTR-4090294", "R-RNO-9664873", "R-CFA-8852276", "R-RNO-3065676", "R-BTA-9931269", "R-BTA-1295596", "R-MMU-156827", "R-CEL-9615933", "R-SSC-937041", "R-RNO-6807004", "R-MMU-8939902", "R-CFA-9706369", "R-BTA-917729", "R-CFA-5357905", "R-HSA-8875360", "R-CEL-3371453", "R-HSA-8939236", "R-DDI-9646399", "R-XTR-4570464", "R-MMU-9833482", "R-HSA-4641257", "R-HSA-174113", "R-BTA-9762114", "R-SCE-3899300", "R-CEL-9856649", "R-HSA-2173789", "R-RNO-9013507", "R-MMU-674695", "R-GGA-174178", "R-CFA-9646399", "R-MMU-8866427", "R-BTA-6783310", "R-DDI-68949", "R-RNO-5689896", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-GGA-9931295", "R-CFA-110320", "R-GGA-3108214", "R-HSA-2122948", "R-CFA-9762114", "R-HSA-2559585", "R-GGA-9793242", "R-SSC-5696397", "R-CEL-936440", "R-HSA-167152", "R-CFA-450408", "R-HSA-9833110", "R-GGA-353299", "R-HSA-2173796", "R-SSC-8866904", "R-SSC-6804757", "R-GGA-5696397", "R-MMU-8849469", "R-BTA-9664873", "R-SSC-5696394", "R-BTA-174048", "R-BTA-6804760", "R-RNO-4755510", "R-BTA-1799339", "R-HSA-5668541", "R-DME-432395", "R-MMU-936440", "R-MMU-9758274", "R-DDI-174178", "R-SSC-9954716", "R-DDI-9954716", "R-HSA-4655427", "R-MMU-9770562", "R-CEL-8941858", "R-CEL-532668", "R-DME-5696394", "R-BTA-6804757", "R-BTA-6804756", "R-SSC-4615885", "R-DME-5654727", "R-MMU-8866654", "R-DME-432524", "R-BTA-196791", "R-MMU-2173796", "R-GGA-877312", "R-DDI-5696394", "R-RNO-3232142", "R-SSC-8939236", "R-HSA-179409", "R-DME-9010553", "R-CFA-983168", "R-DRE-5693607", "R-DME-5689901", "R-DME-202424", "R-DME-187577", "R-SSC-450408", "R-GGA-9755511", "R-DRE-877312", "R-BTA-3899300", "R-BTA-4608870", "R-BTA-2871837", "R-GGA-6804756", "R-DDI-69601", "R-CFA-6804760", "R-BTA-8866427", "R-DME-8863795", "R-GGA-532668", "R-CFA-8849469", "R-MMU-5696400", "R-SSC-8941858", "R-BTA-8849469", "R-GGA-912631", "R-CFA-9954716", "R-HSA-8983711", "R-BTA-5696394", "R-CFA-201681", "R-MMU-5675482", "R-MMU-5656169", "R-HSA-72764", "R-BTA-4641263", "R-SSC-187577", "R-MMU-5676590", "R-GGA-9954709", "R-SSC-4551638", "R-HSA-5357956", "R-CFA-3134975", "R-DME-6782210", "R-GGA-917729", "R-HSA-9725370", "R-HSA-8849469", "R-MMU-9856649", "R-MMU-5632684", "R-BTA-5610785", "R-SSC-4641263", "R-MMU-2467813", "R-MMU-2173791", "R-DDI-5693565", "R-SPO-3065678", "R-BTA-9033241", "R-GGA-8854050", "R-SPO-5696395", "R-BTA-9758274", "R-DDI-9954714", "R-BTA-5675482", "R-CEL-4551638", "R-MMU-9929356", "R-HSA-389977", "R-CEL-110312", "R-CEL-2173795", "R-RNO-156827", "R-DDI-8948751", "R-CEL-2173796", "R-GGA-434131", "R-SSC-3232118", "R-SSC-1234176", "R-MMU-9708530"], "pathways": ["R-GGA-68867:r:Assembly of the pre-replicative complex", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-8948747:r:Regulation of PTEN localization", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-BTA-9646399:r:Aggrephagy", "R-BTA-72649:r:Translation initiation complex formation", "R-CFA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-8948747:r:Regulation of PTEN localization", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-CEL-3232142:r:SUMOylation of ubiquitinylation proteins", "R-GGA-8939902:r:Regulation of RUNX2 expression and activity", "R-GGA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9766229:r:Degradation of CDH1", "R-MMU-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-GGA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-SSC-182971:r:EGFR downregulation", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-68949:r:Orc1 removal from chromatin", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-5685942:r:HDR through Homologous Recombination (HRR)", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SSC-209543:r:p75NTR recruits signalling complexes", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-MMU-69481:r:G2/M Checkpoints", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-SSC-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-CEL-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-1295596:r:Spry regulation of FGF signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9664873:r:Pexophagy", "R-SCE-917937:r:Iron uptake and transport", "R-SCE-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-901032:r:ER Quality Control Compartment (ERQC)", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9615710:r:Late endosomal microautophagy", "R-MMU-8983711:r:OAS antiviral response", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SSC-6783310:r:Fanconi Anemia Pathway", "R-SSC-6782135:r:Dual incision in TC-NER", "R-DME-9646399:r:Aggrephagy", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-SCE-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-9770562:r:mRNA Polyadenylation", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-DME-209560:r:NF-kB is activated and signals survival", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-9766229:r:Degradation of CDH1", "R-CFA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-CFA-69541:r:Stabilization of p53", "R-XTR-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-GGA-1227888:r:Negative Regulation of MDA5 signaling", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-5675482:r:Regulation of necroptotic cell death", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-BTA-1253288:r:Downregulation of ERBB4 signaling", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-3065679:r:SUMO is proteolytically processed", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-9793242:r:SUMOylation of nuclear envelope proteins", "R-CFA-912631:r:Regulation of signaling by CBL", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-SSC-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-110312:r:Translesion synthesis by REV1", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CFA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-9648002:r:RAS processing", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CFA-9766229:r:Degradation of CDH1", "R-BTA-5689877:r:Josephin domain DUBs", "R-RNO-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-SSC-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-GGA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CFA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-2559585:r:Oncogene Induced Senescence", "R-CFA-6807004:r:Negative regulation of MET activity", "R-CFA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-GGA-433871:r:TRAF6 mediated induction of proinflammatory cytokines", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-5689901:r:Metalloprotease DUBs", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CFA-209560:r:NF-kB is activated and signals survival", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-GGA-9020702:r:Interleukin-1 signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in 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"R-SSC-2173788:r:Downregulation of TGF-beta receptor signaling", "R-GGA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CFA-8951664:r:Neddylation", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-SSC-909733:r:Interferon alpha/beta signaling", "R-DME-912631:r:Regulation of signaling by CBL", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-SSC-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CFA-5656121:r:Translesion synthesis by POLI", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CFA-9648002:r:RAS processing", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-CFA-9932298:r:Degradation of CRY and PER proteins", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-CFA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SSC-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-SSC-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-SCE-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-9683683:r:Maturation of protein E", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-69541:r:Stabilization of p53", "R-SPO-9793242:r:SUMOylation of nuclear envelope proteins", "R-GGA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DRE-4085377:r:SUMOylation of SUMOylation proteins", "R-GGA-110314:r:Recognition of DNA 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"R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-GGA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-6783310:r:Fanconi Anemia Pathway", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-9770562:r:mRNA Polyadenylation", "R-SSC-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-917729:r:Endosomal Sorting Complex 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"R-CFA-9020702:r:Interleukin-1 signaling", "R-HSA-110312:r:Translesion synthesis by REV1", "R-CFA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-CEL-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-DRE-4615885:r:SUMOylation of DNA replication proteins", "R-CFA-75815:r:Ubiquitin-dependent degradation of Cyclin D", 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"R-SPO-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-CEL-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SSC-4090294:r:SUMOylation of intracellular receptors", "R-BTA-9648002:r:RAS processing", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-SSC-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of 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GG-NER", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-5689877:r:Josephin domain DUBs", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-202424:r:Downstream TCR signaling", "R-GGA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9033241:r:Peroxisomal protein import", "R-CEL-4641257:r:Degradation of AXIN", "R-CFA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9833482:r:PKR-mediated signaling", "R-CFA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-CFA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-SCE-3065679:r:SUMO is proteolytically processed", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-69231:r:Cyclin D associated events in G1", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", 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"R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-6807004:r:Negative regulation of MET activity", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-8866427:r:VLDLR internalisation and degradation", "R-CEL-3065679:r:SUMO is proteolytically processed", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-69481:r:G2/M Checkpoints", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-9766229:r:Degradation of CDH1", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-5358346:r:Hedgehog ligand biogenesis", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-CFA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-9770562:r:mRNA Polyadenylation", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-SSC-5358346:r:Hedgehog ligand biogenesis", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9706369:r:Negative regulation of FLT3", "R-DDI-9833482:r:PKR-mediated signaling", "R-CFA-68867:r:Assembly of the pre-replicative complex", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-CEL-2672351:r:Stimuli-sensing channels", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CFA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SSC-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5689877:r:Josephin domain DUBs", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-DDI-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-CFA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-BTA-5654726:r:Negative regulation of FGFR1 signaling", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SPO-3232118:r:SUMOylation of transcription factors", "R-CFA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-977225:r:Amyloid fiber formation", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-CFA-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-2672351:r:Stimuli-sensing channels", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-GGA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-CFA-5607764:r:CLEC7A (Dectin-1) signaling", "R-CFA-209543:r:p75NTR recruits signalling complexes", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-5603027:r:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "R-RNO-182971:r:EGFR downregulation", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-5689603:r:UCH proteinases", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CFA-2672351:r:Stimuli-sensing channels", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SSC-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SCE-4085377:r:SUMOylation of SUMOylation proteins", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-CFA-8866427:r:VLDLR internalisation and degradation", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-4641258:r:Degradation of DVL", "R-CEL-917937:r:Iron uptake and transport", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-CEL-9648002:r:RAS processing", "R-SSC-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CFA-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-5689896:r:Ovarian tumor domain proteases", "R-SSC-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SSC-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689877:r:Josephin domain DUBs", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-CFA-9033241:r:Peroxisomal protein import", "R-SSC-9708530:r:Regulation of BACH1 activity", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-CFA-5696400:r:Dual Incision in GG-NER", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-CFA-5689877:r:Josephin domain DUBs", "R-SSC-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-3065679:r:SUMO is proteolytically processed", "R-BTA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-3065679:r:SUMO is proteolytically processed", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-9664873:r:Pexophagy", "R-CEL-912631:r:Regulation of signaling by CBL", "R-SSC-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-69541:r:Stabilization of p53", "R-DDI-5632684:r:Hedgehog 'on' state", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-202424:r:Downstream TCR signaling", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9694493:r:Maturation of protein E", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-912631:r:Regulation of signaling by CBL", "R-DME-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-DDI-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-3232118:r:SUMOylation of transcription factors", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-573298:r:NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation", "R-BTA-4570464:r:SUMOylation of RNA binding proteins", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-GGA-69541:r:Stabilization of p53", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5689603:r:UCH proteinases", "R-SSC-2672351:r:Stimuli-sensing channels", "R-SSC-9793242:r:SUMOylation of nuclear envelope proteins", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-GGA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CFA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-CFA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-GGA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-5357905:r:Regulation of TNFR1 signaling", "R-SCE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SSC-4655427:r:SUMOylation of DNA methylation proteins", "R-SSC-912631:r:Regulation of signaling by CBL", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-CFA-5656169:r:Termination of translesion DNA synthesis", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-SSC-9932298:r:Degradation of CRY and PER proteins", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-SSC-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-GGA-1295596:r:Spry regulation of FGF signaling", "R-DDI-5689880:r:Ub-specific processing proteases", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-4615885:r:SUMOylation of DNA replication proteins", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-9648002:r:RAS processing", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-CFA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-GGA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-SSC-5655862:r:Translesion synthesis by POLK", "R-BTA-3232118:r:SUMOylation of transcription factors", "R-BTA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CFA-9664873:r:Pexophagy", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-GGA-382556:r:ABC-family proteins mediated transport", "R-DME-8948747:r:Regulation of PTEN localization", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-CFA-6782135:r:Dual incision in TC-NER", "R-CFA-4641257:r:Degradation of AXIN", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-68949:r:Orc1 removal from chromatin", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-CEL-4570464:r:SUMOylation of RNA binding proteins", "R-CFA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-CFA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-110312:r:Translesion synthesis by REV1", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CFA-5689880:r:Ub-specific processing proteases", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-SSC-877312:r:Regulation of IFNG signaling", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-SSC-9706369:r:Negative regulation of FLT3", "R-DME-5689603:r:UCH proteinases", "R-SSC-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-CFA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-XTR-3899300:r:SUMOylation of transcription cofactors", "R-SCE-4551638:r:SUMOylation of chromatin organization proteins", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-SSC-5632684:r:Hedgehog 'on' state", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-5689877:r:Josephin domain DUBs", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-382556:r:ABC-family proteins mediated transport", "R-CEL-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-9648002:r:RAS processing", "R-RNO-72649:r:Translation initiation complex formation", "R-MMU-9646399:r:Aggrephagy", "R-GGA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-GGA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-68949:r:Orc1 removal from chromatin", "R-GGA-8951664:r:Neddylation", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-9770562:r:mRNA Polyadenylation", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DME-917937:r:Iron uptake and transport", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-182971:r:EGFR downregulation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-SSC-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-SSC-5696400:r:Dual Incision in GG-NER", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SPO-3065679:r:SUMO is proteolytically processed", "R-GGA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-GGA-5689896:r:Ovarian tumor domain proteases", "R-DDI-5358346:r:Hedgehog ligand biogenesis", "R-DME-8951664:r:Neddylation", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CFA-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-5675221:r:Negative regulation of MAPK pathway", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-GGA-69231:r:Cyclin D associated events in G1", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-5656169:r:Termination of translesion DNA synthesis", "R-DME-110320:r:Translesion Synthesis by POLH", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3769402:r:Deactivation 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PD-L1(CD274)", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-CFA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SSC-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-CFA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CFA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SSC-5689603:r:UCH proteinases", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-912631:r:Regulation of signaling by CBL", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-CFA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-9664873:r:Pexophagy", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-9793242:r:SUMOylation of nuclear envelope proteins", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-SSC-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CFA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-6782135:r:Dual incision in TC-NER", "R-GGA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-5656121:r:Translesion synthesis by POLI", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9766229:r:Degradation of CDH1", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-CFA-2467813:r:Separation of Sister Chromatids", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-68949:r:Orc1 removal from chromatin", "R-GGA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SSC-5689901:r:Metalloprotease DUBs", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-975956:r:Nonsense Mediated 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"R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-GGA-6782135:r:Dual incision in TC-NER", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-CFA-382556:r:ABC-family proteins mediated transport", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-4641258:r:Degradation of DVL", "R-BTA-4641258:r:Degradation of DVL", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CFA-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-6807004:r:Negative regulation 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"R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-CFA-5655862:r:Translesion synthesis by POLK", "R-CFA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-5654733:r:Negative regulation of FGFR4 signaling", "R-BTA-917937:r:Iron uptake and transport", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CFA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SSC-9931295:r:PD-L1(CD274) glycosylation and translocation to 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"R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CFA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-9020702:r:Interleukin-1 signaling", "R-SSC-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-4641258:r:Degradation of DVL", "R-GGA-8849469:r:PTK6 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"R-SSC-8951664:r:Neddylation", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-CFA-110312:r:Translesion synthesis by REV1", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-CFA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SSC-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-538864:r:Degradation of CRY", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT 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"R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-4085377:r:SUMOylation of SUMOylation proteins", "R-CEL-877312:r:Regulation of IFNG signaling", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-HSA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-CFA-917937:r:Iron uptake and transport", "R-DDI-8951664:r:Neddylation", "R-SSC-4641257:r:Degradation of AXIN", "R-MMU-8951664:r:Neddylation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-5689603:r:UCH proteinases", "R-SSC-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CFA-1234176:r:Oxygen-dependent proline 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"R-MMU-9648002:r:RAS processing", "R-CEL-9646399:r:Aggrephagy", "R-GGA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-HSA-5334118:r:DNA methylation", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-SSC-4641258:r:Degradation of DVL", "R-MMU-9033241:r:Peroxisomal protein import", "R-BTA-5689603:r:UCH proteinases", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-917937:r:Iron uptake and transport", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-GGA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-DDI-9033241:r:Peroxisomal protein import", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-GGA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-8983711:r:OAS antiviral response", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-BTA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-DRE-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-8951664:r:Neddylation", "R-GGA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9648002:r:RAS processing", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-BTA-9833482:r:PKR-mediated signaling", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-72689:r:Formation of a 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"R-MMU-9706369:r:Negative regulation of FLT3", "R-GGA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-4655427:r:SUMOylation of DNA methylation proteins", "R-DME-5696400:r:Dual Incision in GG-NER", "R-HSA-877300:r:Interferon gamma signaling", "R-CFA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-182971:r:EGFR downregulation", "R-SSC-9033241:r:Peroxisomal protein import", "R-GGA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-RNO-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-GGA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CFA-2871837:r:FCERI mediated NF-kB activation", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-4641258:r:Degradation of DVL", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 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"R-HSA-9646399:r:Aggrephagy", "R-SSC-8948751:r:Regulation of PTEN stability and activity", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DME-5655862:r:Translesion synthesis by POLK", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DDI-5689901:r:Metalloprotease DUBs", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-4641258:r:Degradation of DVL", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-GGA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-GGA-9646399:r:Aggrephagy", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-XTR-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-3065679:r:SUMO is proteolytically processed", "R-DDI-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CFA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CFA-69231:r:Cyclin D associated events in G1", "R-GGA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-CEL-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-8948747:r:Regulation of PTEN localization", "R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SCE-5689603:r:UCH proteinases", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-CFA-4641258:r:Degradation of DVL", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-BTA-9706369:r:Negative regulation of FLT3", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-GGA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-4641257:r:Degradation of AXIN", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CFA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-3065679:r:SUMO is proteolytically processed", "R-GGA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CFA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-4755510:r:SUMOylation of immune response proteins", "R-RNO-5689603:r:UCH proteinases", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CFA-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-SSC-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-GGA-2672351:r:Stimuli-sensing channels", "R-HSA-9793242:r:SUMOylation of nuclear envelope proteins", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-SSC-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-GGA-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-937039:r:IRAK1 recruits IKK complex", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-69481:r:G2/M Checkpoints", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-SSC-69231:r:Cyclin D associated events in G1", "R-CFA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-877312:r:Regulation of IFNG signaling", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-110312:r:Translesion synthesis by REV1", "R-BTA-5689901:r:Metalloprotease DUBs", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-BTA-4755510:r:SUMOylation of immune response proteins", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-SCE-8951664:r:Neddylation", "R-GGA-209543:r:p75NTR recruits signalling complexes", "R-DME-182971:r:EGFR downregulation", "R-CFA-909733:r:Interferon alpha/beta signaling", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-SSC-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-BTA-4090294:r:SUMOylation of intracellular receptors", "R-RNO-4641257:r:Degradation of AXIN", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-5689603:r:UCH proteinases", "R-SSC-9020702:r:Interleukin-1 signaling", "R-GGA-9033241:r:Peroxisomal protein import", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-5632684:r:Hedgehog 'on' state", "R-XTR-4090294:r:SUMOylation of intracellular receptors", "R-RNO-9664873:r:Pexophagy", "R-CFA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-1295596:r:Spry 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"ATP/ADP-dependent (S)-NAD(P)H-hydrate dehydratase", "go_ids": ["GO:0016836"], "go_terms": ["GO:0016836:hydro-lyase activity:F"], "name": "CARKD", "pathway_ids": ["R-SPO-196807", "R-MMU-196807", "R-BTA-196807", "R-DME-196807", "R-DRE-196807", "R-SCE-196807", "R-CEL-196807", "R-HSA-196807", "R-DDI-196807", "R-RNO-196807"], "pathways": ["R-SPO-196807:r:Nicotinate metabolism", "R-MMU-196807:r:Nicotinate metabolism", "R-BTA-196807:r:Nicotinate metabolism", "R-DME-196807:r:Nicotinate metabolism", "R-DRE-196807:r:Nicotinate metabolism", "R-SCE-196807:r:Nicotinate metabolism", "R-CEL-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism"], "type": "Domain"}, "IPR000635": {"description": "Viral ssDNA-binding protein", "go_ids": ["GO:0003697", "GO:0006260", "GO:0042025"], "go_terms": ["GO:0003697:single-stranded DNA binding:F", "GO:0006260:DNA replication:P", "GO:0042025:host cell nucleus:C"], "name": "Viral_ssDNA-bd", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR000638": {"description": "Gas vesicle protein GvpA-like", "go_ids": ["GO:0005198", "GO:0012506"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0012506:vesicle membrane:C"], "name": "Gas-vesicle_GvpA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000640": {"description": "Elongation factor EFG, domain V-like", "go_ids": [], "go_terms": [], "name": "EFG_V-like", "pathway_ids": ["R-DME-5358493", "R-HSA-6798695", "R-SCE-8876725", "R-SPO-6798695", "R-HSA-8876725", "R-HSA-5419276", "R-RNO-5358493", "R-CEL-156902", "R-CEL-6798695", "R-SPO-72163", "R-SCE-6798695", "R-BTA-6798695", "R-BTA-5358493", "R-DRE-156902", "R-DME-156902", "R-SPO-156902", "R-SPO-5358493", "R-HSA-5336415", "R-RNO-5419276", "R-DRE-6798695", "R-HSA-72165", "R-HSA-5389840", "R-DDI-156902", "R-HSA-9918481", "R-BTA-8876725", "R-RNO-5389840", "R-DRE-5419276", "R-DRE-5358493", "R-DDI-6798695", "R-RNO-156902", "R-SCE-5358493", "R-CEL-5358493", "R-CEL-5389840", "R-MMU-72163", "R-DME-6798695", "R-HSA-156902", "R-CEL-8876725", "R-SPO-8876725", "R-DRE-5389840", "R-DDI-8876725", "R-MMU-156902", "R-MMU-8876725", "R-DME-8876725", "R-HSA-72163", "R-DRE-8876725", "R-MMU-5358493", "R-MMU-72165", "R-SCE-156902", "R-BTA-156902", "R-HSA-5358493", "R-RNO-8876725", "R-MMU-5419276", "R-MMU-6798695", "R-BTA-5419276", "R-DME-5419276", "R-DME-5389840", "R-DDI-5358493", "R-MMU-5389840", "R-RNO-6798695"], "pathways": ["R-DME-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-8876725:r:Protein methylation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-8876725:r:Protein methylation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-RNO-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-156902:r:Peptide chain elongation", "R-CEL-6798695:r:Neutrophil degranulation", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-156902:r:Peptide chain elongation", "R-DME-156902:r:Peptide chain elongation", "R-SPO-156902:r:Peptide chain elongation", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DDI-156902:r:Peptide chain elongation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-8876725:r:Protein methylation", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-DRE-5419276:r:Mitochondrial translation termination", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-156902:r:Peptide chain elongation", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-156902:r:Peptide chain elongation", "R-CEL-8876725:r:Protein methylation", "R-SPO-8876725:r:Protein methylation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-DDI-8876725:r:Protein methylation", "R-MMU-156902:r:Peptide chain elongation", "R-MMU-8876725:r:Protein methylation", "R-DME-8876725:r:Protein methylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-8876725:r:Protein methylation", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-156902:r:Peptide chain elongation", "R-BTA-156902:r:Peptide chain elongation", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-8876725:r:Protein methylation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR000642": {"description": "Peptidase M41", "go_ids": ["GO:0004222", "GO:0005524", "GO:0006508", "GO:0004176"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0005524:ATP binding:F", "GO:0006508:proteolysis:P", "GO:0004176:ATP-dependent peptidase activity:F"], "name": "Peptidase_M41", "pathway_ids": ["PWY-8119", "R-HSA-9840373", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-8949664", "R-DME-9837999", "R-SPO-9840373", "R-RNO-9840373", "R-RNO-9837999", "R-MMU-8949664", "R-SCE-9840373", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-DME-8949664", "R-CEL-8949664", "R-HSA-8949664", "R-HSA-9837999", "R-RNO-8949664", "R-MMU-9840373"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-8949664:r:Processing of SMDT1", "R-DME-9837999:r:Mitochondrial protein degradation", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-8949664:r:Processing of SMDT1", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-8949664:r:Processing of SMDT1", "R-CEL-8949664:r:Processing of SMDT1", "R-HSA-8949664:r:Processing of SMDT1", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-8949664:r:Processing of SMDT1", "R-MMU-9840373:r:Cellular response to mitochondrial stress"], "type": "Domain"}, "IPR000643": {"description": "Iodothyronine deiodinase", "go_ids": ["GO:0004800"], "go_terms": ["GO:0004800:thyroxine 5'-deiodinase activity:F"], "name": "Iodothyronine_deiodinase", "pathway_ids": ["PWY-6261", "PWY-6260", "R-RNO-350864", "R-CFA-350864", "R-BTA-350864", "R-SSC-350864", "R-MMU-350864", "R-HSA-350864"], "pathways": ["PWY-6261:t:thyroid hormone metabolism II (via conjugation and/or degradation)", "PWY-6260:t:thyroid hormone metabolism I (via deiodination)", "R-RNO-350864:r:Regulation of thyroid hormone activity", "R-CFA-350864:r:Regulation of thyroid hormone activity", "R-BTA-350864:r:Regulation of thyroid hormone activity", "R-SSC-350864:r:Regulation of thyroid hormone activity", "R-MMU-350864:r:Regulation of thyroid hormone activity", "R-HSA-350864:r:Regulation of thyroid hormone activity"], "type": "Family"}, "IPR000644": 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"R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-2672351:r:Stimuli-sensing channels", "R-RNO-1632852:r:Macroautophagy", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-6798695:r:Neutrophil degranulation", "R-SPO-200425:r:Carnitine shuttle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-9613354:r:Lipophagy", "R-SCE-200425:r:Carnitine shuttle", "R-RNO-9748787:r:Azathioprine ADME", "R-RNO-1614603:r:Cysteine formation from homocysteine", "R-DDI-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-MMU-9748787:r:Azathioprine ADME", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-1614603:r:Cysteine formation from homocysteine", 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mediated degradation of PD-L1(CD274)", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-6798695:r:Neutrophil degranulation", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DRE-9748787:r:Azathioprine ADME", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1614603:r:Cysteine formation from homocysteine", "R-MMU-1614603:r:Cysteine formation from homocysteine", "R-CEL-2672351:r:Stimuli-sensing channels", "R-SCE-1614603:r:Cysteine formation from homocysteine", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-200425:r:Carnitine shuttle", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-9748787:r:Azathioprine ADME", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity"], "type": "Domain"}, "IPR000646": {"description": "Pre-hexon-linking protein VIII", "go_ids": ["GO:0031423", "GO:0019028"], "go_terms": ["GO:0031423:hexon binding:F", "GO:0019028:viral capsid:C"], "name": "Adeno_PVIII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000647": {"description": "CTF transcription factor/nuclear factor 1", "go_ids": ["GO:0003700", "GO:0005634", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "CTF/NFI", "pathway_ids": ["R-HSA-73980", "R-HSA-749476"], "pathways": ["R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation"], "type": "Family"}, "IPR000648": {"description": "Oxysterol-binding protein", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "Oxysterol-bd", "pathway_ids": ["R-RNO-2132295", "R-MMU-9013407", "R-HSA-2132295", "R-MMU-192105", "R-HSA-192105", "R-HSA-1660661", "R-DDI-192105", "R-HSA-1482801", "R-RNO-192105", "R-SCE-1482801", "R-SPO-192105", "R-XTR-192105", "R-MMU-2132295", "R-DDI-1482801", "R-SPO-1482801", "R-SCE-192105", "R-MMU-1482801", "R-HSA-9013407"], "pathways": ["R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-2132295:r:MHC class II antigen presentation", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-DDI-192105:r:Synthesis of bile acids and bile salts", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-SCE-1482801:r:Acyl chain remodelling of PS", "R-SPO-192105:r:Synthesis of bile acids and bile salts", "R-XTR-192105:r:Synthesis of bile acids and bile salts", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DDI-1482801:r:Acyl chain remodelling of PS", "R-SPO-1482801:r:Acyl chain remodelling of PS", "R-SCE-192105:r:Synthesis of bile acids and bile salts", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR000649": {"description": "Initiation factor 2B-related", "go_ids": [], "go_terms": [], "name": "IF-2B-related", "pathway_ids": ["PWY-7174", "PWY-8130", "PWY-8132", "PWY-8131", "PWY-4361", "R-DRE-1237112", "R-SCE-72731", "R-HSA-72731", "R-MMU-72731", "R-CEL-72731", "R-SPO-1237112", "R-RNO-1237112", "R-DDI-72731", "R-SPO-72731", "R-MMU-1237112", "R-BTA-72731", "R-XTR-1237112", "R-RNO-72731", "R-CEL-1237112", "R-DME-1237112", "R-HSA-1237112"], "pathways": ["PWY-7174:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II", "PWY-8130:t:5'-deoxyadenosine degradation I", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8131:t:5'-deoxyadenosine degradation II", "PWY-4361:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I", "R-DRE-1237112:r:Methionine salvage pathway", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-CEL-72731:r:Recycling of eIF2:GDP", "R-SPO-1237112:r:Methionine salvage pathway", "R-RNO-1237112:r:Methionine salvage pathway", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-MMU-1237112:r:Methionine salvage pathway", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-XTR-1237112:r:Methionine salvage pathway", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-CEL-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-HSA-1237112:r:Methionine salvage pathway"], "type": "Family"}, "IPR000651": {"description": "Ras-like guanine nucleotide exchange factor, N-terminal", "go_ids": [], "go_terms": [], "name": "Ras-like_Gua-exchang_fac_N", "pathway_ids": ["R-HSA-9607240", "R-MMU-180336", "R-BTA-5673001", "R-HSA-2871796", "R-HSA-912631", "R-MMU-210993", "R-HSA-9027284", "R-HSA-442982", "R-CEL-9607240", "R-DDI-5213460", "R-MMU-5654706", "R-SCE-8980692", "R-HSA-8853659", "R-DME-74751", "R-MMU-8851805", "R-DDI-5673000", "R-MMU-5673001", "R-MMU-186763", "R-RNO-193648", "R-DME-1433559", "R-MMU-167044", "R-DME-9607240", "R-DME-9013149", "R-HSA-983695", "R-HSA-2424491", "R-MMU-392517", "R-DDI-5673001", "R-HSA-416482", "R-RNO-9013148", "R-HSA-8983432", "R-SCE-193648", "R-CEL-74751", "R-HSA-5637810", "R-HSA-5654699", "R-MMU-912526", "R-MMU-171007", "R-HSA-1433559", "R-HSA-5654700", "R-DDI-5674135", "R-CEL-1433557", "R-CEL-8851805", "R-DME-193648", "R-MMU-179812", "R-DME-416482", "R-MMU-193648", "R-DRE-8980692", "R-MMU-2730905", "R-MMU-5654712", "R-HSA-179812", "R-MMU-354192", "R-HSA-392517", "R-HSA-9680350", "R-HSA-5655253", "R-DME-180336", "R-DME-5673001", "R-MMU-8980692", "R-MMU-5654699", "R-RNO-8980692", "R-SCE-6798695", "R-HSA-9665348", "R-HSA-2428933", "R-SCE-381676", "R-CEL-2179392", "R-DME-1433557", "R-HSA-9013423", "R-XTR-5673001", "R-RNO-416482", "R-RNO-354192", "R-CEL-5654712", "R-MMU-1250347", "R-CEL-354192", "R-HSA-9013148", "R-MMU-5654704", "R-HSA-1250196", "R-HSA-2730905", "R-MMU-112412", "R-HSA-5654719", "R-DME-5654699", "R-CEL-193648", "R-HSA-1963640", "R-HSA-5655291", "R-HSA-5655332", "R-DME-5654719", "R-DME-2179392", "R-DME-112412", "R-DDI-392517", "R-DME-167044", "R-HSA-5654712", "R-HSA-2871809", "R-HSA-9034864", "R-MMU-9028731", "R-MMU-354194", "R-MMU-8983432", "R-HSA-74749", "R-HSA-9842663", "R-DDI-5675221", "R-DME-2730905", "R-HSA-180336", "R-DME-74749", "R-XTR-354192", "R-DME-5654712", "R-RNO-422356", "R-CEL-179812", "R-HSA-9634285", "R-HSA-912526", "R-HSA-170968", "R-HSA-428540", "R-MMU-5654693", "R-DME-186763", "R-DRE-193648", "R-MMU-9013149", "R-DME-5654706", "R-MMU-74749", "R-MMU-1963640", "R-HSA-422356", "R-HSA-5654688", "R-HSA-1989781", "R-DDI-354192", "R-MMU-1433559", "R-CEL-210993", "R-HSA-8875555", "R-MMU-9607240", "R-DME-375165", "R-CEL-354194", "R-SCE-416482", "R-RNO-9013149", "R-DME-912631", "R-HSA-2179392", "R-HSA-9670439", "R-HSA-9026519", "R-CEL-416482", "R-HSA-5654693", "R-DRE-5673001", "R-CEL-5673001", "R-MMU-381676", "R-MMU-2871796", "R-DDI-5675482", "R-RNO-392517", "R-DME-210993", "R-DME-2424491", "R-SCE-9013149", "R-CEL-1433559", "R-CEL-5654700", "R-CFA-5673001", "R-MMU-74751", "R-XTR-1169092", "R-BTA-392517", "R-DDI-9013423", "R-HSA-9673767", "R-XTR-392517", "R-RNO-5673001", "R-HSA-9664565", "R-HSA-5655302", "R-CEL-5654693", "R-MMU-2428933", "R-DDI-193648", "R-DME-5654704", "R-HSA-9665686", "R-MMU-1433557", "R-HSA-210993", "R-MMU-8853659", "R-MMU-5654700", "R-DME-5654688", "R-SCE-354192", "R-HSA-5673001", "R-SCE-9013148", "R-HSA-9013149", "R-DME-2871796", "R-HSA-8980692", "R-SCE-9035034", "R-DME-8853659", "R-HSA-9703648", "R-HSA-381676", "R-CEL-1963640", "R-DME-1963640", "R-BTA-354192", "R-CEL-186763", "R-MMU-5654688", "R-DRE-416482", "R-HSA-5654704", "R-SCE-392517", "R-MMU-375165", "R-CEL-375165", "R-MMU-1169092", "R-MMU-2179392", "R-HSA-167044", "R-SCE-9013423", "R-DME-5654700", "R-HSA-74751", "R-MMU-422356", "R-DME-5654693", "R-MMU-9013148", "R-HSA-375165", "R-HSA-1250347", "R-DDI-9013149", "R-DME-2428933", "R-MMU-9842663", "R-CEL-9013149", "R-HSA-2871837", "R-DDI-381676", "R-HSA-9673770", "R-HSA-114508", "R-CEL-5654706", "R-HSA-1169092", "R-DME-2871809", "R-HSA-1236382", "R-DRE-9013149", "R-CEL-5654699", "R-DME-1250347", "R-SCE-9013424", "R-HSA-8851805", "R-MMU-5654719", "R-HSA-9028731", "R-HSA-171007", "R-HSA-354192", "R-HSA-193648", "R-RNO-171007", "R-DDI-171007", "R-DDI-3295583", "R-CEL-392517", "R-HSA-5654706", "R-HSA-354194", "R-HSA-9679191", "R-MMU-983695", "R-DDI-1169092", "R-HSA-1433557", "R-RNO-381676", "R-CEL-381676", "R-CEL-180336", "R-HSA-186763", "R-RNO-1169092", "R-HSA-9703465", "R-DRE-9013148", "R-MMU-2871809", "R-HSA-112412", "R-MMU-416482", "R-MMU-2424491", "R-DME-179812", "R-DME-9013423", "R-CEL-5654704"], "pathways": ["R-HSA-9607240:r:FLT3 Signaling", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-CEL-9607240:r:FLT3 Signaling", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-DME-74751:r:Insulin receptor signalling cascade", "R-MMU-8851805:r:MET activates RAS signaling", "R-DDI-5673000:r:RAF activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-RNO-193648:r:NRAGE signals death through JNK", "R-DME-1433559:r:Regulation of KIT signaling", "R-MMU-167044:r:Signalling to RAS", "R-DME-9607240:r:FLT3 Signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2424491:r:DAP12 signaling", "R-MMU-392517:r:Rap1 signalling", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SCE-193648:r:NRAGE signals death through JNK", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-171007:r:p38MAPK events", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-8851805:r:MET activates RAS signaling", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-MMU-354192:r:Integrin signaling", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-SCE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-354192:r:Integrin signaling", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-112412:r:SOS-mediated signalling", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-112412:r:SOS-mediated signalling", "R-DDI-392517:r:Rap1 signalling", "R-DME-167044:r:Signalling to RAS", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-74749:r:Signal attenuation", "R-HSA-9842663:r:Signaling by LTK", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-DME-74749:r:Signal attenuation", "R-XTR-354192:r:Integrin signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-186763:r:Downstream signal transduction", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-74749:r:Signal attenuation", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-354192:r:Integrin signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-9607240:r:FLT3 Signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DME-912631:r:Regulation of signaling by CBL", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-RNO-392517:r:Rap1 signalling", "R-DME-210993:r:Tie2 Signaling", "R-DME-2424491:r:DAP12 signaling", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-XTR-1169092:r:Activation of RAS in B cells", "R-BTA-392517:r:Rap1 signalling", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-XTR-392517:r:Rap1 signalling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-210993:r:Tie2 Signaling", "R-MMU-8853659:r:RET signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-SCE-354192:r:Integrin signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-9035034:r:RHOF GTPase cycle", "R-DME-8853659:r:RET signaling", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-354192:r:Integrin signaling", "R-CEL-186763:r:Downstream signal transduction", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-SCE-392517:r:Rap1 signalling", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-MMU-1169092:r:Activation of RAS in B cells", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-167044:r:Signalling to RAS", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-MMU-422356:r:Regulation of insulin secretion", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-DDI-9013149:r:RAC1 GTPase cycle", 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"R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-74259:r:Purine catabolism", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Domain"}, "IPR000675": {"description": "Cutinase/acetylxylan esterase", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Cutinase/axe", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000678": {"description": "Nuclear transition protein 2", "go_ids": ["GO:0000786", "GO:0003677", "GO:0005634", "GO:0007283"], "go_terms": ["GO:0000786:nucleosome:C", "GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0007283:spermatogenesis:P"], "name": "TP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000679": {"description": "Zinc finger, GATA-type", "go_ids": ["GO:0006355", "GO:0043565"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0043565:sequence-specific DNA binding:F"], "name": "Znf_GATA", "pathway_ids": ["R-HSA-2032785", "R-CEL-983231", "R-HSA-8936459", "R-HSA-5689880", "R-MMU-3214815", "R-DRE-8939236", "R-RNO-8936459", "R-MMU-5689880", "R-HSA-9844594", "R-RNO-983231", "R-HSA-9823730", "R-RNO-3232118", "R-HSA-8943724", "R-MMU-3232118", "R-HSA-9616222", "R-HSA-9690406", "R-HSA-9018519", "R-DRE-9018519", "R-MMU-8936459", "R-SPO-9018519", "R-HSA-9830364", "R-DME-9018519", "R-HSA-983231", "R-HSA-3214815", "R-HSA-6785807", "R-RNO-73762", "R-RNO-8939236", "R-MMU-9018519", "R-GGA-983231", "R-HSA-5683826", "R-HSA-3232118", "R-MMU-6804758", "R-MMU-73762", "R-RNO-8943724", "R-CEL-8936459", "R-HSA-9925561", "R-GGA-9018519", "R-MMU-983231", "R-BTA-983231", "R-MMU-8939236", "R-HSA-6804758", "R-HSA-5578768", "R-RNO-3214815", "R-GGA-8939236", "R-HSA-9845323", "R-DME-5683826", "R-DDI-9018519", "R-DME-983231", "R-HSA-9938206", "R-CFA-983231", "R-DDI-5689880", "R-MMU-5683826", "R-HSA-400511", "R-HSA-9925563", "R-HSA-9937080", "R-DME-8939236", "R-HSA-9679191", "R-HSA-73762", "R-RNO-5683826", "R-MMU-8943724", "R-CEL-5689880", "R-SCE-9018519", "R-DRE-983231", "R-DME-8936459", "R-HSA-9733709", "R-CEL-9018519", "R-HSA-9758920", "R-HSA-9843940", "R-HSA-427389", "R-HSA-8939236", "R-DME-5689880"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-3214815:r:HDACs deacetylate histones", "R-DRE-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9823730:r:Formation of definitive endoderm", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9830364:r:Formation of the nephric duct", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-GGA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-GGA-9018519:r:Estrogen-dependent gene expression", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-5578768:r:Physiological factors", "R-RNO-3214815:r:HDACs deacetylate histones", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-5683826:r:Surfactant metabolism", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-CFA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-CEL-5689880:r:Ub-specific processing proteases", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9733709:r:Cardiogenesis", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR000680": {"description": "Variable large protein, Borrelia", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Borrelia_lipo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000682": {"description": "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "go_ids": ["GO:0036211", "GO:0004719"], "go_terms": ["GO:0036211:protein modification process:P", "GO:0004719:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity:F"], "name": "PCMT", "pathway_ids": ["R-SPO-5676934", "R-HSA-5676934", "R-DDI-5676934", "R-DRE-5676934", "R-CEL-5676934", "R-SSC-5676934", "R-RNO-5676934", "R-MMU-5676934", "R-DME-5676934"], "pathways": ["R-SPO-5676934:r:Protein repair", "R-HSA-5676934:r:Protein repair", "R-DDI-5676934:r:Protein repair", "R-DRE-5676934:r:Protein repair", "R-CEL-5676934:r:Protein repair", "R-SSC-5676934:r:Protein repair", "R-RNO-5676934:r:Protein repair", "R-MMU-5676934:r:Protein repair", "R-DME-5676934:r:Protein repair"], "type": "Family"}, "IPR000683": {"description": "Gfo/Idh/MocA-like oxidoreductase, N-terminal", "go_ids": ["GO:0000166"], "go_terms": ["GO:0000166:nucleotide binding:F"], "name": "Gfo/Idh/MocA-like_OxRdtase_N", "pathway_ids": ["R-MMU-189483", "R-MMU-9707564", "R-XTR-9013406", "R-MMU-9013406", "R-HSA-9707564", "R-RNO-9707564", "R-HSA-9013406", "R-RNO-189483", "R-HSA-189483"], "pathways": ["R-MMU-189483:r:Heme degradation", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-XTR-9013406:r:RHOQ 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"R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-6782135:r:Dual incision in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6782135:r:Dual incision in TC-NER", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Repeat"}, "IPR000685": {"description": "Ribulose bisphosphate carboxylase, large subunit, C-terminal", "go_ids": ["GO:0000287", "GO:0016984"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0016984:ribulose-bisphosphate carboxylase activity:F"], "name": "RuBisCO_lsu_C", "pathway_ids": ["PWY-5723", "PWY-5532"], "pathways": ["PWY-5723:t:Rubisco shunt", "PWY-5532:t:nucleoside and nucleotide degradation (archaea)"], "type": "Domain"}, "IPR000686": {"description": "Fanconi anaemia group C protein", "go_ids": ["GO:0043240", "GO:0036297"], "go_terms": ["GO:0043240:Fanconi anaemia nuclear complex:C", "GO:0036297:interstrand cross-link repair:P"], "name": "FANCC", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-HSA-6796648", "R-RNO-9833482", "R-RNO-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR000687": {"description": "RIO kinase", "go_ids": ["GO:0004674", "GO:0005524"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F"], "name": "RIO_kinase", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-SPO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR000688": {"description": "Hydrogenase maturation factor HypA/HybF", "go_ids": ["GO:0016151", "GO:0051604"], "go_terms": ["GO:0016151:nickel cation binding:F", "GO:0051604:protein maturation:P"], "name": "HypA/HybF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000689": {"description": "Ubiquinone biosynthesis monooxygenase COQ6", "go_ids": ["GO:0106364", "GO:0006744"], "go_terms": ["GO:0106364:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity:F", "GO:0006744:ubiquinone biosynthetic process:P"], "name": "UbQ_mOase_COQ6", "pathway_ids": ["R-DRE-2142789", "R-SCE-2142789", "R-SPO-2142789", "R-MMU-2142789", "R-DDI-2142789", "R-HSA-2142789", "R-BTA-2142789", "R-RNO-2142789", "R-CEL-2142789", "R-DME-2142789"], "pathways": ["R-DRE-2142789:r:Ubiquinol biosynthesis", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-BTA-2142789:r:Ubiquinol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-CEL-2142789:r:Ubiquinol biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis"], "type": "Family"}, "IPR000692": {"description": "rRNA 2'-O-methyltransferase fibrillarin-like", "go_ids": ["GO:0003723", "GO:0006364", "GO:0008168"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006364:rRNA processing:P", "GO:0008168:methyltransferase activity:F"], "name": "Fibrillarin", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-MMU-6791226", "R-SCE-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR000693": {"description": "Sea anemone toxin", "go_ids": ["GO:0005576", "GO:0009966"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0009966:regulation of signal transduction:P"], "name": "Anenome_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000696": {"description": "Peptidase A6, nodavirus coat protein", "go_ids": ["GO:0004190", "GO:0006508"], "go_terms": ["GO:0004190:aspartic-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_A6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000697": {"description": "WH1/EVH1 domain", "go_ids": [], "go_terms": [], "name": "WH1/EVH1_dom", "pathway_ids": ["R-HSA-5663213", "R-HSA-9013409", "R-BTA-2029482", "R-MMU-446353", "R-BTA-9013424", "R-HSA-202433", "R-HSA-8856828", "R-BTA-373753", "R-BTA-3928662", "R-BTA-9013406", "R-DDI-446353", "R-HSA-9013424", "R-HSA-418885", "R-HSA-3928662", "R-HSA-6794361", "R-DME-9013148", "R-BTA-5663213", "R-BTA-6794361", "R-HSA-9013148", "R-DME-3928665", "R-MMU-5658442", "R-MMU-5658623", "R-DME-446353", "R-HSA-6802953", "R-HSA-5658623", "R-HSA-203641", "R-HSA-373753", "R-BTA-8856828", "R-DME-9013149", "R-DRE-5658623", "R-DME-8980692", "R-DDI-5658442", "R-HSA-376176", "R-MMU-6794361", "R-DME-3928662", "R-HSA-2029482", "R-RNO-5658623", "R-RNO-5663220", "R-BTA-418885", "R-HSA-9013149", "R-MMU-376176", "R-HSA-5658442", "R-DRE-5658442", "R-HSA-446353", "R-DME-193648", "R-RNO-5658442", "R-DME-416482", "R-BTA-203641", "R-HSA-5663220", "R-HSA-9013406", "R-RNO-6794361", "R-HSA-9664422", "R-DME-9013423", "R-MMU-5663220"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-BTA-9013424:r:RHOV GTPase cycle", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-373753:r:Nephrin family interactions", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-DDI-446353:r:Cell-extracellular matrix interactions", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DME-9013148:r:CDC42 GTPase cycle", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-HSA-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-373753:r:Nephrin family interactions", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-DME-8980692:r:RHOA GTPase cycle", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-376176:r:Signaling by ROBO receptors", "R-MMU-6794361:r:Neurexins and neuroligins", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-BTA-418885:r:DCC mediated attractive signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-DME-193648:r:NRAGE signals death through JNK", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-DME-416482:r:G alpha (12/13) signalling events", "R-BTA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-6794361:r:Neurexins and neuroligins", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR000698": {"description": "Arrestin", "go_ids": ["GO:0007165"], "go_terms": ["GO:0007165:signal transduction:P"], "name": "Arrestin", "pathway_ids": ["R-BTA-8856825", "R-HSA-8856825", "R-DME-9839389", "R-BTA-432722", "R-MMU-418555", "R-DME-5689880", "R-MMU-8856828", "R-HSA-5674135", "R-BTA-5689880", "R-HSA-6802952", "R-HSA-5689880", "R-HSA-8856828", "R-CEL-5099900", "R-MMU-5099900", "R-HSA-2485179", "R-CEL-432722", "R-BTA-2514859", "R-MMU-5689880", "R-MMU-456926", "R-HSA-9649948", "R-HSA-6802955", "R-RNO-432722", "R-DME-5674135", "R-HSA-6802948", "R-MMU-5635838", "R-HSA-2514859", "R-RNO-432720", "R-HSA-456926", "R-HSA-432720", "R-HSA-418555", "R-CEL-5674135", "R-CEL-456926", "R-RNO-5689880", "R-RNO-456926", "R-HSA-5635838", "R-BTA-418555", "R-CEL-8856825", "R-RNO-2514859", "R-HSA-9656223", "R-RNO-418555", "R-DME-432720", "R-DME-418555", "R-MMU-5674135", "R-HSA-2122948", "R-MMU-8856825", "R-CEL-432720", "R-MMU-432722", "R-BTA-5674135", "R-HSA-9839389", "R-BTA-9839389", "R-HSA-6802946", "R-MMU-2514859", "R-DME-8856828", "R-RNO-8856828", "R-RNO-5674135", "R-RNO-9839389", "R-RNO-5099900", "R-HSA-432722", "R-MMU-432720", "R-BTA-8856828", "R-DME-8856825", "R-CEL-8856828", "R-BTA-5635838", "R-RNO-8856825", "R-MMU-9839389", "R-BTA-432720", "R-BTA-456926", "R-HSA-5099900", "R-DME-432722"], "pathways": ["R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-418555:r:G alpha (s) signalling events", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-5635838:r:Activation of SMO", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-418555:r:G alpha (s) signalling events", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-5635838:r:Activation of SMO", "R-BTA-418555:r:G alpha (s) signalling events", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-RNO-418555:r:G alpha (s) signalling events", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-DME-418555:r:G alpha (s) signalling events", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-5635838:r:Activation of SMO", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR000699": {"description": "RIH domain", "go_ids": ["GO:0005262", "GO:0016020", "GO:0070588"], "go_terms": ["GO:0005262:calcium channel activity:F", "GO:0016020:membrane:C", "GO:0070588:calcium ion transmembrane transport:P"], "name": "RIH_dom", "pathway_ids": ["R-MMU-139853", "R-HSA-139853", "R-CEL-983695", "R-HSA-5607763", "R-DDI-139853", "R-HSA-2672351", "R-HSA-1489509", "R-HSA-2029485", "R-DDI-5578775", "R-DME-114508", "R-MMU-418457", "R-MMU-381676", "R-RNO-2672351", "R-HSA-418457", "R-HSA-112043", "R-HSA-114508", "R-MMU-9717207", "R-MMU-2672351", "R-DDI-381676", "R-CEL-114508", "R-CEL-9717207", "R-RNO-139853", "R-DME-139853", "R-RNO-418457", "R-HSA-5578775", "R-HSA-4086398", "R-RNO-114508", "R-DME-381676", "R-MMU-114508", "R-HSA-983695", "R-RNO-9717207", "R-DME-5578775", "R-DDI-9717207", "R-RNO-5578775", "R-CEL-139853", "R-HSA-2871809", "R-MMU-5578775", "R-DME-983695", "R-DME-9717207", "R-MMU-983695", "R-RNO-381676", "R-CEL-381676", "R-HSA-5218921", "R-HSA-9717207", "R-CEL-5578775", "R-HSA-381676", "R-RNO-983695", "R-DDI-114508", "R-HSA-9664323", "R-HSA-422356"], "pathways": ["R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-CEL-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DDI-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-1489509:r:DAG and IP3 signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-5578775:r:Ion homeostasis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-MMU-418457:r:cGMP effects", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-418457:r:cGMP effects", "R-HSA-112043:r:PLC beta mediated events", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-MMU-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-CEL-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-DME-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-418457:r:cGMP effects", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-4086398:r:Ca2+ pathway", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-DME-5578775:r:Ion homeostasis", "R-DDI-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-5578775:r:Ion homeostasis", "R-CEL-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5578775:r:Ion homeostasis", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-5578775:r:Ion homeostasis", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR000701": {"description": "Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit", "go_ids": [], "go_terms": [], "name": "SuccDH_FuR_B_TM-su", "pathway_ids": ["R-HSA-611105", "R-HSA-9854311", "R-SPO-71403", "R-SSC-71403", "R-BTA-9854311", "R-MMU-9854311", "R-MMU-71403", "R-SCE-71403", "R-BTA-71403", "R-DDI-71403", "R-SSC-9854311", "R-HSA-71403"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Family"}, "IPR000702": {"description": "Large ribosomal subunit protein 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"R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality 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mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000704": {"description": "Casein kinase II, regulatory subunit", "go_ids": ["GO:0005956", "GO:0019887"], "go_terms": ["GO:0005956:protein kinase CK2 complex:C", "GO:0019887:protein kinase regulator activity:F"], "name": "Casein_kinase_II_reg-sub", "pathway_ids": ["R-HSA-6798695", "R-RNO-8948751", "R-RNO-8934903", "R-DRE-9768727", "R-RNO-1483191", "R-SSC-8948751", "R-CEL-6798695", "R-MMU-1483191", "R-MMU-6804756", "R-SCE-6804756", "R-BTA-6798695", "R-SSC-8934903", "R-MMU-8948751", "R-DME-8948751", "R-SPO-6804756", "R-RNO-8939243", "R-SSC-8939243", "R-BTA-9929491", "R-SPO-8934903", "R-HSA-9828806", "R-BTA-6804756", "R-HSA-9931530", "R-DRE-6798695", "R-MMU-9929491", "R-CEL-6804756", "R-BTA-2514853", "R-DDI-6804756", "R-DRE-6814122", "R-RNO-9768727", "R-SSC-1483191", "R-DRE-2514853", "R-DDI-6798695", "R-DRE-201688", "R-HSA-8934903", "R-DRE-6804756", "R-HSA-9929491", "R-DRE-8948751", "R-SPO-2514853", "R-DRE-8934903", "R-RNO-445144", "R-DRE-1483191", "R-RNO-2514853", "R-DDI-8948751", "R-DDI-2514853", "R-HSA-9755511", "R-MMU-2514853", "R-MMU-445144", "R-DME-6804756", "R-HSA-8939243", "R-DME-445144", "R-HSA-6804756", "R-SSC-6814122", "R-BTA-8934903", "R-BTA-9768727", "R-BTA-8939243", "R-HSA-8948751", "R-HSA-445144", "R-MMU-6798695", "R-CEL-8948751", "R-HSA-9931529", "R-BTA-1483191", "R-HSA-9768727", "R-MMU-9768727", "R-RNO-6798695", "R-RNO-201688", "R-SPO-6798695", "R-SSC-6798695", "R-MMU-8934903", "R-DME-432553", "R-SCE-6798695", "R-HSA-2514853", "R-MMU-201688", "R-DRE-8939243", "R-CEL-6814122", "R-DME-209214", "R-CEL-1483191", "R-SCE-8948751", "R-SSC-2514853", "R-SCE-8934903", "R-DME-2514853", "R-RNO-6804756", "R-SCE-2514853", "R-BTA-6814122", "R-SSC-6804756", "R-MMU-6814122", 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"R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-SSC-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-2514853:r:Condensation of Prometaphase Chromosomes", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SSC-1483191:r:Synthesis of PC", "R-DRE-2514853:r:Condensation of Prometaphase Chromosomes", "R-DDI-6798695:r:Neutrophil degranulation", "R-DRE-201688:r:WNT mediated activation of DVL", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-RNO-445144:r:Signal transduction by L1", "R-DRE-1483191:r:Synthesis of PC", "R-RNO-2514853:r:Condensation of Prometaphase Chromosomes", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-DDI-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-MMU-445144:r:Signal transduction by L1", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-445144:r:Signal transduction by L1", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9931529:r:Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK", "R-BTA-1483191:r:Synthesis of PC", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-201688:r:WNT mediated activation of DVL", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-MMU-201688:r:WNT mediated activation of DVL", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-209214:r:Phosphorylation of SMO", "R-CEL-1483191:r:Synthesis of PC", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-SSC-2514853:r:Condensation of Prometaphase Chromosomes", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-DME-2514853:r:Condensation of Prometaphase Chromosomes", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-SSC-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-DME-209190:r:Phosphorylation of CI", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-201688:r:WNT mediated activation of DVL", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-445144:r:Signal transduction by L1", "R-SSC-201688:r:WNT mediated activation of DVL", "R-DME-8934903:r:Receptor Mediated Mitophagy", "R-SSC-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-1483191:r:Synthesis of PC", "R-DME-201688:r:WNT mediated activation of DVL", "R-CEL-201688:r:WNT mediated activation of DVL", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-BTA-201688:r:WNT mediated activation of DVL", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Family"}, "IPR000705": {"description": "Galactokinase", "go_ids": ["GO:0004335", "GO:0005524", "GO:0006012", "GO:0046835"], "go_terms": ["GO:0004335:galactokinase activity:F", "GO:0005524:ATP binding:F", "GO:0006012:galactose metabolic process:P", "GO:0046835:carbohydrate phosphorylation:P"], "name": "Galactokinase", "pathway_ids": ["PWY-6527", "PWY-3821", "PWY-6317", "R-HSA-70370", "R-HSA-5609976", "R-MMU-70370", "R-CFA-70370", "R-BTA-70370"], "pathways": ["PWY-6527:t:stachyose degradation", "PWY-3821:t:D-galactose detoxification", "PWY-6317:t:D-galactose degradation I (Leloir pathway)", "R-HSA-70370:r:Galactose catabolism", "R-HSA-5609976:r:Defective GALK1 causes GALCT2", "R-MMU-70370:r:Galactose catabolism", "R-CFA-70370:r:Galactose catabolism", "R-BTA-70370:r:Galactose catabolism"], "type": "Family"}, "IPR000706": {"description": "N-acetyl-gamma-glutamyl-phosphate reductase, type 1", "go_ids": ["GO:0003942", "GO:0006526", "GO:0070401"], "go_terms": ["GO:0003942:N-acetyl-gamma-glutamyl-phosphate reductase activity:F", "GO:0006526:L-arginine biosynthetic process:P", "GO:0070401:NADP+ binding:F"], "name": "AGPR_type-1", "pathway_ids": ["PWY-5154", "R-DDI-70635", "R-SCE-70635", "R-SPO-70635"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-DDI-70635:r:Urea cycle", "R-SCE-70635:r:Urea cycle", "R-SPO-70635:r:Urea cycle"], "type": "Family"}, "IPR000711": {"description": "ATPase, OSCP/delta subunit", "go_ids": ["GO:0015986", "GO:0046933"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P", "GO:0046933:proton-transporting ATP synthase activity, rotational mechanism:F"], "name": "ATPase_OSCP/dsu", "pathway_ids": ["R-DDI-9837999", "R-MMU-9837999", "R-SSC-8949613", "R-DME-9837999", "R-MMU-163210", "R-DME-163210", "R-RNO-9837999", "R-DME-8949613", "R-HSA-8949613", "R-HSA-163210", "R-BTA-8949613", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-SSC-9837999", "R-BTA-163210", "R-HSA-9837999", "R-RNO-163210", "R-RNO-8949613", "R-MMU-8949613", "R-SSC-163210"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SSC-8949613:r:Cristae formation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DME-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-BTA-8949613:r:Cristae formation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-SSC-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR000713": {"description": "Mur ligase, N-terminal catalytic domain", "go_ids": ["GO:0009058", "GO:0016881"], "go_terms": ["GO:0009058:biosynthetic process:P", "GO:0016881:acid-amino acid ligase activity:F"], "name": "Mur_ligase_N", "pathway_ids": ["PWY-7953", "PWY-6387", "PWY-6386"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "type": "Domain"}, "IPR000714": {"description": "Equine herpesvirus protein of unknown function", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "EHV_Unk", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000715": {"description": "Glycosyl transferase, family 4", "go_ids": ["GO:0016780", "GO:0016020"], "go_terms": ["GO:0016780:phosphotransferase activity, for other substituted phosphate groups:F", "GO:0016020:membrane:C"], "name": "Glycosyl_transferase_4", "pathway_ids": ["PWY-6470", "PWY-6471", "PWY-5265", "PWY-6385", "R-SCE-446193", "R-MMU-446193", "R-SPO-446193", "R-HSA-446193", "R-DDI-446193", "R-HSA-4549356"], "pathways": ["PWY-6470:t:peptidoglycan biosynthesis V (beta-lactam resistance)", "PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "R-SCE-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DDI-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-4549356:r:Defective DPAGT1 causes CDG-1j, CMSTA2"], "type": "Family"}, "IPR000716": {"description": "Thyroglobulin type-1", "go_ids": [], "go_terms": [], "name": "Thyroglobulin_1", "pathway_ids": ["R-HSA-2132295", "R-XTR-381426", "R-HSA-3000157", "R-RNO-3000157", "R-SSC-202733", "R-HSA-9927418", "R-MMU-8957275", "R-BTA-8957275", "R-HSA-9638630", "R-HSA-380994", "R-HSA-9615017", "R-RNO-202733", "R-RNO-8957275", "R-MMU-202733", "R-MMU-2132295", "R-BTA-381426", "R-MMU-381426", "R-HSA-9938206", "R-HSA-6803211", "R-RNO-6803211", "R-MMU-6803211", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-9925563", "R-RNO-2132295", "R-MMU-3000157", "R-SSC-381426", "R-SSC-8957275", "R-MMU-1592389", "R-HSA-9927432", "R-GGA-202733", "R-HSA-1592389", "R-RNO-381426", "R-DRE-381426", "R-HSA-8957275", "R-BTA-6803211", "R-HSA-202733", "R-HSA-9927426"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-XTR-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3000157:r:Laminin interactions", "R-RNO-3000157:r:Laminin interactions", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-RNO-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-MMU-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-3000157:r:Laminin interactions", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Domain"}, "IPR000717": {"description": "Proteasome component (PCI) domain", "go_ids": [], "go_terms": [], "name": "PCI_dom", "pathway_ids": ["R-DRE-4641258", "R-XTR-69481", "R-HSA-174178", "R-HSA-9604323", "R-RNO-9013422", "R-BTA-5689880", "R-HSA-8951664", "R-HSA-9010553", "R-CEL-8941858", "R-XTR-5696394", "R-DME-5696394", "R-SPO-5689880", "R-MMU-5689880", "R-DDI-9929491", "R-GGA-68949", "R-XTR-9762114", "R-RNO-8854050", "R-XTR-174154", "R-MMU-5696394", "R-HSA-450408", "R-CEL-5696394", "R-DRE-69017", "R-RNO-450408", "R-SCE-5689880", "R-HSA-211733", "R-DDI-6798695", "R-XTR-4608870", "R-DME-4641257", "R-DME-432524", "R-DRE-8948751", "R-GGA-8948751", "R-MMU-1234176", "R-DDI-5696394", "R-GGA-9931269", "R-BTA-69017", "R-DRE-5610785", "R-BTA-349425", "R-DDI-382556", "R-DME-202424", "R-MMU-187577", "R-DME-187577", "R-GGA-9755511", "R-DME-72649", "R-XTR-72702", "R-HSA-9824272", "R-BTA-4608870", "R-BTA-5676590", "R-MMU-349425", "R-GGA-1236978", "R-BTA-2871837", "R-DME-174084", "R-BTA-174154", "R-DDI-69601", "R-DME-9929491", "R-DDI-5689880", "R-DRE-174178", "R-SSC-6781823", "R-GGA-9929491", "R-DRE-5358346", "R-CEL-9755511", "R-BTA-5696394", "R-DME-6798695", "R-RNO-9755511", "R-DME-174184", "R-BTA-9929356", "R-MMU-5676590", "R-GGA-9954709", "R-BTA-9013422", "R-GGA-5689880", "R-RNO-68867", "R-RNO-350562", "R-DME-9932298", "R-RNO-9762114", "R-XTR-68867", "R-BTA-9954709", "R-DDI-156827", "R-CEL-9762114", "R-CEL-8951664", "R-HSA-5358346", "R-HSA-6798695", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-GGA-450408", "R-BTA-5610785", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-BTA-6798695", "R-XTR-8948751", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-8951664", "R-GGA-382556", "R-GGA-8854050", "R-GGA-9932298", "R-RNO-174154", "R-CEL-5689603", "R-MMU-9929356", "R-XTR-5689880", "R-HSA-69481", "R-DME-9762114", "R-RNO-156827", "R-BTA-174084", "R-SPO-72706", "R-DDI-8948751", "R-BTA-5358346", "R-XTR-6798695", "R-RNO-8939236", "R-SPO-5689603", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-GGA-68867", "R-CEL-69017", "R-XTR-174184", "R-RNO-2467813", "R-DME-5607764", "R-DME-209406", "R-BTA-72649", "R-DME-2871837", "R-DME-8941858", "R-DRE-382556", "R-SPO-6798695", "R-XTR-5632684", "R-BTA-382556", "R-GGA-350562", "R-CEL-72702", "R-CEL-8939902", "R-XTR-9954709", "R-CEL-72695", "R-MMU-72649", "R-GGA-174154", "R-RNO-5610780", "R-GGA-8939236", "R-GGA-8939902", "R-DME-5689603", "R-DME-216167", "R-SSC-8856825", "R-MMU-5658442", "R-HSA-174084", "R-GGA-2467813", "R-MMU-4608870", "R-BTA-5610780", "R-RNO-9907900", "R-DME-72695", "R-MMU-72702", "R-RNO-8856825", "R-HSA-69601", "R-HSA-72689", "R-HSA-983168", "R-BTA-5689603", "R-BTA-8856825", "R-SCE-72649", "R-DDI-349425", "R-RNO-8941858", "R-RNO-1169091", "R-HSA-69017", "R-BTA-9020702", "R-DRE-72689", "R-RNO-9766229", "R-MMU-1236978", "R-DRE-68867", "R-HSA-202424", "R-GGA-5610780", "R-DDI-174154", "R-CEL-4641257", "R-RNO-2871837", "R-XTR-5689603", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-DRE-1169091", "R-MMU-8941858", "R-MMU-174154", "R-MMU-9020702", "R-DME-5658442", "R-CEL-195253", "R-RNO-382556", "R-RNO-5687128", "R-DRE-8939236", "R-MMU-69481", "R-DDI-8856825", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-HSA-8854050", "R-DRE-187577", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-DRE-174184", "R-SCE-72702", "R-BTA-68867", "R-HSA-9929491", "R-RNO-5689880", "R-RNO-5696394", "R-RNO-72649", "R-DRE-9755511", "R-GGA-72649", "R-RNO-8951664", "R-GGA-195253", "R-CEL-72649", "R-HSA-1236974", "R-DME-1234176", "R-DME-72702", "R-DRE-4608870", "R-MMU-5687128", "R-RNO-5358346", "R-XTR-6781823", "R-DME-5358346", "R-RNO-6798695", "R-CEL-72689", "R-HSA-68949", "R-DRE-349425", "R-MMU-8852276", "R-MMU-72689", "R-BTA-68949", "R-MMU-68949", "R-GGA-8951664", "R-GGA-5607764", "R-GGA-2871837", "R-BTA-6781823", "R-MMU-6781823", "R-GGA-8941858", "R-XTR-5610780", "R-GGA-9907900", "R-DDI-2467813", "R-RNO-349425", "R-BTA-174184", "R-DRE-6781823", "R-BTA-8939236", "R-HSA-5610780", "R-SCE-1236978", "R-DME-432626", "R-GGA-5696394", "R-DME-9013422", "R-MMU-5607761", "R-HSA-8939902", "R-CEL-5689880", "R-DRE-72702", "R-DME-174178", "R-GGA-9929356", "R-RNO-195253", "R-HSA-9013422", "R-DRE-5632684", "R-DME-8951664", "R-HSA-9766229", "R-GGA-1234176", "R-CEL-187577", "R-DRE-1236978", "R-RNO-72695", "R-BTA-9929491", "R-MMU-9013422", "R-MMU-9929491", "R-BTA-9932298", "R-GGA-6781823", "R-SSC-9013422", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-DDI-5658442", "R-BTA-450408", "R-DDI-72695", "R-HSA-8941858", "R-DRE-1234176", "R-CEL-9929491", "R-GGA-6798695", "R-DME-9755511", "R-DRE-5658442", "R-MMU-2871837", "R-XTR-9907900", "R-RNO-174084", "R-DME-5610785", "R-HSA-5689603", "R-RNO-983168", "R-GGA-174084", "R-DDI-72702", "R-BTA-8951664", "R-DME-1169091", "R-MMU-8856825", "R-HSA-349425", "R-BTA-8941858", "R-DME-4641258", "R-HSA-174184", "R-MMU-350562", "R-DRE-9929491", "R-BTA-2467813", "R-MMU-5610785", "R-DRE-69481", "R-HSA-9954709", "R-MMU-5358346", "R-GGA-202424", "R-RNO-1236978", "R-DME-68949", "R-DRE-8856825", "R-DME-8856825", "R-DRE-5689880", "R-DRE-156827", "R-CEL-9954709", "R-SPO-72649", "R-SPO-72695", "R-HSA-382556", "R-XTR-156827", "R-HSA-8852276", "R-DRE-174084", "R-DRE-450408", "R-DDI-983168", "R-HSA-9929356", "R-CEL-69601", "R-XTR-174178", "R-RNO-5658442", "R-RNO-5610785", "R-MMU-983168", "R-GGA-9762114", "R-HSA-350562", "R-DME-68867", "R-RNO-5668541", "R-BTA-9755511", "R-HSA-75815", "R-DRE-2467813", "R-MMU-8948751", "R-DME-8948751", "R-DRE-8941858", "R-HSA-72695", "R-CEL-1234176", "R-BTA-1169091", "R-BTA-69481", "R-DME-5676590", "R-GGA-9766229", "R-HSA-5607761", "R-DDI-174084", "R-MMU-9932298", "R-BTA-72702", "R-HSA-72706", "R-MMU-4641258", "R-DRE-9766229", "R-DDI-4641258", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-CEL-8948751", "R-MMU-9766229", "R-RNO-69481", "R-HSA-174154", "R-DDI-187577", "R-GGA-187577", "R-DDI-72689", "R-RNO-1234176", "R-RNO-5632684", "R-RNO-9932298", "R-BTA-1236978", "R-DRE-195253", "R-DRE-5610780", "R-RNO-174178", "R-DRE-4641257", "R-HSA-156827", "R-MMU-174178", "R-DDI-9013422", "R-DRE-983168", "R-DME-350562", "R-HSA-9907900", "R-CEL-8854050", "R-HSA-9762114", "R-HSA-195253", "R-GGA-69601", "R-SCE-156827", "R-BTA-187577", "R-GGA-8856825", "R-GGA-9020702", "R-DME-8939236", "R-RNO-174113", "R-RNO-187577", "R-MMU-174184", "R-XTR-68949", "R-HSA-8856825", "R-GGA-69017", "R-DME-9020702", "R-XTR-8941858", "R-RNO-69017", "R-XTR-5610785", "R-DME-5689880", "R-SPO-350562", "R-BTA-202424", "R-XTR-9766229", "R-DDI-1236978", "R-MMU-72706", "R-DME-8939902", "R-CEL-382556", "R-DRE-6798695", "R-XTR-5607761", "R-XTR-69601", "R-DME-4608870", "R-SCE-5668541", "R-RNO-9929356", "R-BTA-156827", "R-XTR-69017", "R-BTA-5687128", "R-HSA-5678895", "R-DDI-6781823", "R-DRE-9907900", "R-HSA-4641258", "R-DRE-5696394", "R-CEL-6781823", "R-RNO-174184", "R-BTA-4641258", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-XTR-450408", "R-GGA-72702", "R-SPO-72702", "R-MMU-5610780", "R-DME-9954709", "R-DRE-9762114", "R-XTR-2467813", "R-MMU-9755511", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-HSA-5362768", "R-DDI-9954709", "R-RNO-8852276", "R-GGA-5668541", "R-BTA-174178", "R-BTA-9907900", "R-DRE-68949", "R-DDI-69017", "R-BTA-8948751", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-5632684", "R-BTA-8854050", "R-XTR-5358346", "R-DRE-72649", "R-RNO-5607764", "R-XTR-983168", "R-XTR-9755511", "R-XTR-1234176", "R-DDI-450408", "R-BTA-5607764", "R-CEL-350562", "R-GGA-75815", "R-RNO-6781823", "R-GGA-5689603", "R-CEL-5632684", "R-HSA-5689880", "R-BTA-1234176", "R-MMU-69017", "R-XTR-349425", "R-XTR-8939902", "R-BTA-350562", "R-DME-2467813", "R-GGA-5658442", "R-GGA-5632684", "R-DRE-5668541", "R-HSA-1234176", "R-RNO-4641258", "R-HSA-9931269", "R-MMU-68867", "R-DRE-69601", "R-DME-209461", "R-XTR-9929491", "R-XTR-75815", "R-HSA-72702", "R-DRE-5689603", "R-DME-75815", "R-DRE-350562", "R-HSA-5696394", "R-DME-69601", "R-CEL-4608870", "R-CEL-8856825", "R-SPO-72689", "R-DME-69017", "R-DME-983168", "R-GGA-983168", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-DRE-8939902", "R-BTA-195253", "R-SCE-6798695", "R-RNO-69601", "R-CEL-9907900", "R-GGA-5610785", "R-CEL-983168", "R-XTR-8939236", "R-MMU-8939236", "R-RNO-4641257", "R-DME-9907900", "R-DDI-5689603", "R-CEL-75815", "R-DRE-75815", "R-MMU-9762114", "R-GGA-349425", "R-MMU-195253", "R-MMU-202424", "R-MMU-72695", "R-SCE-72695", "R-MMU-382556", "R-DME-209360", "R-DRE-174154", "R-DDI-5687128", "R-BTA-5632684", "R-BTA-9931269", "R-DDI-9907900", "R-DME-72689", "R-RNO-75815", "R-RNO-72702", "R-MMU-1169091", "R-XTR-8852276", "R-XTR-8951664", "R-HSA-72649", "R-MMU-156827", "R-DME-8854050", "R-XTR-174084", "R-DRE-9932298", "R-MMU-8939902", "R-XTR-9932298", "R-GGA-1169091", "R-DRE-9013422", "R-XTR-382556", "R-HSA-8939236", "R-DRE-8854050", "R-XTR-5676590", "R-DDI-8854050", "R-BTA-983168", "R-GGA-4608870", "R-MMU-5607764", "R-DME-6781823", "R-DRE-8951664", "R-BTA-5668541", "R-GGA-5358346", "R-HSA-5676590", "R-DRE-9954709", "R-DDI-5632684", "R-BTA-72689", "R-XTR-5687128", "R-GGA-5687128", "R-HSA-4641257", "R-RNO-202424", "R-BTA-72695", "R-HSA-174113", "R-BTA-9762114", "R-XTR-350562", "R-RNO-5607761", "R-GGA-4641257", "R-CEL-4641258", "R-XTR-1236978", "R-DRE-72695", "R-HSA-9755511", "R-RNO-9931269", "R-CEL-156827", "R-HSA-1169091", "R-GGA-174178", "R-HSA-5658442", "R-BTA-8852276", "R-XTR-5668541", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-SPO-156827", "R-GGA-72695", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-HSA-187577", "R-DME-156827", "R-DDI-9755511", "R-DME-382556", "R-GGA-4641258", "R-DME-5610780", "R-SSC-8951664", "R-RNO-72689", "R-DME-195253", "R-MMU-69601", "R-DRE-8852276", "R-XTR-4641257", "R-MMU-8854050", "R-DME-5607761", "R-MMU-5689603", "R-HSA-5607764", "R-XTR-72695", "R-DRE-5687128", "R-CEL-1236978", "R-RNO-4608870", "R-DME-538864", "R-GGA-174184", "R-SCE-9907900", "R-HSA-5668541", "R-CEL-68949", "R-DME-5632684", "R-HSA-5687128", "R-DME-432395", "R-XTR-195253", "R-DDI-174178", "R-XTR-1169091"], "pathways": ["R-DRE-4641258:r:Degradation of DVL", "R-XTR-69481:r:G2/M Checkpoints", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-XTR-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-68949:r:Orc1 removal from chromatin", "R-XTR-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-XTR-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-XTR-4608870:r:Asymmetric localization of PCP proteins", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-GGA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-GGA-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-72649:r:Translation initiation complex formation", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9824272:r:Somitogenesis", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-GGA-5689880:r:Ub-specific processing proteases", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-GGA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-XTR-8948751:r:Regulation of PTEN stability and activity", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-GGA-382556:r:ABC-family proteins mediated transport", "R-GGA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-GGA-9932298:r:Degradation of CRY and PER proteins", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-5689603:r:UCH proteinases", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-XTR-5689880:r:Ub-specific processing proteases", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-5689603:r:UCH proteinases", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-GGA-68867:r:Assembly of the pre-replicative complex", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-XTR-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-SPO-6798695:r:Neutrophil degranulation", "R-XTR-5632684:r:Hedgehog 'on' state", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-GGA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-XTR-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72649:r:Translation initiation complex formation", "R-GGA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-GGA-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-5689603:r:UCH proteinases", "R-DME-216167:r:Nuclear CI is degraded", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-9907900:r:Proteasome assembly", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-72649:r:Translation initiation complex formation", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-RNO-9766229:r:Degradation of CDH1", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-68867:r:Assembly of the pre-replicative complex", "R-HSA-202424:r:Downstream TCR signaling", "R-GGA-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-4641257:r:Degradation of AXIN", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-XTR-5689603:r:UCH proteinases", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-69481:r:G2/M Checkpoints", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DRE-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-72649:r:Translation initiation complex formation", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-72649:r:Translation initiation complex formation", "R-RNO-8951664:r:Neddylation", "R-GGA-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-72649:r:Translation initiation complex formation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-HSA-68949:r:Orc1 removal 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"R-RNO-9734091", "R-HSA-196299", "R-RNO-418594", "R-CEL-8854050", "R-SPO-68884", "R-BTA-209543", "R-RNO-9645460", "R-DDI-6796648", "R-MMU-9841922", "R-MMU-201451", "R-CEL-164378", "R-CEL-171007", "R-GGA-1433557", "R-RNO-5627117", "R-HSA-195253", "R-HSA-9706369", "R-DDI-5693616", "R-DDI-9833482", "R-HSA-9665249", "R-MMU-6796648", "R-BTA-180292", "R-BTA-187577", "R-DRE-420029", "R-HSA-6785631", "R-HSA-9034864", "R-HSA-190371", "R-MMU-354194", "R-HSA-6807004", "R-MMU-1257604", "R-DME-8934903", "R-DME-2173795", "R-HSA-9842663", "R-SPO-180024", "R-BTA-674695", "R-DRE-190374", "R-DME-2730905", "R-CEL-2672351", "R-MMU-174184", "R-HSA-8856825", "R-MMU-5654727", "R-HSA-75955", "R-DRE-375165", "R-HSA-9680187", "R-DME-9020702", "R-RNO-432040", "R-CEL-198323", "R-MMU-937041", "R-MMU-1963640", "R-CFA-9856649", "R-RNO-877300", "R-MMU-975871", "R-CEL-2022928", "R-DRE-1266695", "R-MMU-5625740", "R-RNO-5357905", "R-HSA-6796648", "R-CFA-1257604", "R-BTA-9627069", "R-MMU-389357", "R-DDI-170968", "R-BTA-389359", "R-HSA-5693607", "R-BTA-9856649", "R-RNO-196299", "R-DME-3371571", "R-MMU-9706374", "R-XTR-5607761", "R-BTA-5620912", "R-BTA-937041", "R-HSA-8943724", "R-RNO-1474151", "R-MMU-74751", "R-BTA-5693607", "R-HSA-2023837", "R-DDI-9013423", "R-DRE-9018519", "R-HSA-212718", "R-DDI-163680", "R-HSA-373753", "R-DDI-444257", "R-MMU-180292", "R-DME-437239", "R-BTA-2559580", "R-HSA-210993", "R-BTA-5687128", "R-HSA-9918432", "R-HSA-9034793", "R-DDI-3214858", "R-DDI-432040", "R-BTA-196299", "R-SPO-983231", "R-MMU-2559580", "R-RNO-111932", "R-HSA-194306", "R-DRE-354192", "R-XTR-5218921", "R-HSA-5218921", "R-SPO-8980692", "R-SPO-69202", "R-RNO-174184", "R-BTA-5668599", "R-CEL-6804758", "R-HSA-5635838", "R-DME-9841251", "R-BTA-176408", "R-MMU-8854521", "R-SPO-75035", "R-HSA-975110", "R-DDI-9031628", "R-DME-1474151", "R-DDI-1489509", "R-BTA-5673000", "R-RNO-75953", "R-RNO-194306", "R-BTA-5654726", "R-SCE-6782135", "R-RNO-432142", "R-DRE-9013423", "R-HSA-399956", "R-DME-5654700", "R-RNO-109704", "R-BTA-5654727", "R-RNO-2173788", "R-HSA-1660499", "R-BTA-68962", "R-RNO-68881", "R-RNO-1912408", "R-HSA-171319", "R-HSA-6804758", "R-DRE-5654219", "R-MMU-9931295", "R-HSA-5610787", "R-DRE-9013149", "R-MMU-110056", "R-CEL-68911", "R-HSA-525793", "R-MMU-2995383", "R-MMU-6814122", "R-MMU-389948", "R-BTA-8948751", "R-MMU-1170546", "R-HSA-9645135", "R-CEL-198693", "R-HSA-9013973", "R-CEL-5675221", "R-CEL-8934903", "R-HSA-168276", "R-GGA-389356", "R-SCE-2559580", "R-DME-5654689", "R-DDI-1660516", "R-DME-196299", "R-DME-180024", "R-RNO-381676", "R-DME-209397", "R-DDI-8963896", "R-DDI-202670", "R-BTA-180024", "R-HSA-9931510", "R-HSA-5603027", "R-CEL-5578775", "R-SPO-6804758", "R-MMU-8875656", "R-DME-190373", "R-HSA-3899300", "R-DME-176417", "R-HSA-69202", "R-XTR-2500257", "R-HSA-392451", "R-SSC-6788467", "R-MMU-418885", "R-RNO-6781823", "R-MMU-9674555", "R-DRE-186797", "R-MMU-198323", "R-MMU-69017", "R-MMU-881907", "R-SSC-912526", "R-RNO-1433559", "R-DME-5218921", 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"R-DME-211163", "R-CEL-182971", "R-SCE-200425", "R-DME-5663213", "R-RNO-165159", "R-GGA-5673001", "R-DME-9607240", "R-SPO-6811558", "R-MMU-9013407", "R-MMU-380259", "R-MMU-170968", "R-BTA-381676", "R-MMU-9634597", "R-HSA-3000171", "R-MMU-3134975", "R-DRE-186763", "R-HSA-373752", "R-RNO-2980767", "R-RNO-202670", "R-DDI-111995", "R-HSA-190377", "R-HSA-389356", "R-DRE-6785807", "R-MMU-171007", "R-DME-442720", "R-HSA-399954", "R-BTA-9768727", "R-BTA-69017", "R-DME-390089", "R-DRE-8980692", "R-DME-2559586", "R-DDI-113418", "R-MMU-72086", "R-SPO-73779", "R-DME-1963642", "R-CEL-2173789", "R-RNO-9013420", "R-CEL-9031628", "R-DME-9909505", "R-MMU-187577", "R-RNO-198693", "R-RNO-9860276", "R-CEL-5687128", "R-SCE-69601", "R-DRE-2559580", "R-HSA-9735871", "R-DME-111932", "R-DRE-109704", "R-CEL-5654227", "R-HSA-9824272", "R-RNO-199920", "R-SCE-76005", "R-HSA-8849468", "R-RNO-166208", "R-RNO-2565942", "R-MMU-429947", "R-DDI-8876198", "R-HSA-111446", "R-DDI-112409", "R-BTA-209560", "R-RNO-2173789", 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"R-MMU-937039", "R-CEL-3928663", "R-MMU-198693", "R-SCE-8934903", "R-RNO-110056", "R-DDI-165181", "R-XTR-445989", "R-RNO-201451", "R-CEL-5654710", "R-HSA-9025046", "R-DRE-1059683", "R-DME-4086398", "R-MMU-5674499", "R-CEL-8934593", "R-RNO-442720", "R-GGA-1227739", "R-HSA-9694676", "R-CEL-418592", "R-HSA-9840373", "R-RNO-8856825", "R-SSC-2559582", "R-MMU-5218920", "R-CEL-445144", "R-CEL-9634635", "R-RNO-166058", "R-DRE-4419969", "R-DME-5675482", "R-DRE-5625740", "R-HSA-9665233", "R-XTR-5663220", "R-CEL-416572", "R-BTA-9860927", "R-HSA-9652817", "R-RNO-2559580", "R-SSC-389357", "R-HSA-69017", "R-CEL-3214858", "R-RNO-9766229", "R-SPO-69601", "R-RNO-202430", "R-DME-179812", "R-XTR-6807505", "R-MMU-4755510", "R-DME-9013423", "R-MMU-177929", "R-RNO-2871837", "R-CEL-8939243", "R-RNO-1306955", "R-HSA-9754119", "R-RNO-68949", "R-PFA-8963896", "R-DRE-1169091", "R-MMU-8941858", "R-HSA-9026357", "R-DME-2173788", "R-HSA-9006335", "R-RNO-73779", "R-MMU-937072", "R-MMU-9013409", "R-MMU-445355", "R-HSA-9669935", "R-BTA-9018519", "R-HSA-202427", "R-BTA-9968551", "R-RNO-1632852", "R-RNO-8847993", "R-CEL-1257604", "R-RNO-210990", "R-HSA-73776", "R-HSA-389359", "R-HSA-199418", "R-HSA-9693928", "R-RNO-450385", "R-MMU-5668541", "R-DRE-5621480", "R-DME-1251985", "R-HSA-2122947", "R-BTA-9634597", "R-HSA-9692913", "R-HSA-9614657", "R-DME-1433559", "R-DME-9013149", "R-MMU-196299", "R-RNO-9732724", "R-RNO-2029481", "R-RNO-9013407", "R-HSA-983231", "R-DME-5627123", "R-CFA-9824585", "R-MMU-380270", "R-SSC-3928662", "R-CFA-432142", "R-DRE-909733", "R-DME-1253288", "R-CEL-5654727", "R-HSA-8851708", "R-RNO-5689880", "R-HSA-9634600", "R-DRE-9755511", "R-DME-432620", "R-HSA-1433559", "R-CEL-112411", "R-DME-1257604", "R-HSA-5696395", "R-HSA-418597", "R-BTA-8939243", "R-HSA-9726840", "R-SSC-2559580", "R-HSA-174048", "R-DME-110523", "R-MMU-9851151", "R-MMU-5687128", "R-MMU-186797", "R-MMU-5663220", "R-PFA-171007", "R-SSC-1227986", "R-HSA-1474151", "R-DDI-199418", "R-HSA-933542", "R-MMU-190374", "R-GGA-9856649", "R-BTA-176417", "R-HSA-9634635", "R-HSA-9665348", "R-CEL-3899300", "R-DME-5625740", "R-BTA-9013423", "R-HSA-198765", "R-HSA-2454202", "R-HSA-5357905", "R-HSA-8849470", "R-CEL-389357", "R-MMU-9013507", "R-SPO-9754119", "R-HSA-5654719", "R-HSA-167172", "R-BTA-6814122", "R-HSA-9032845", "R-SSC-9648025", "R-MMU-8983711", "R-SSC-1059683", "R-DME-1250342", "R-HSA-416993", "R-DRE-1307965", "R-HSA-3304356", "R-SPO-9648025", "R-SSC-9006335", "R-DME-9013422", "R-HSA-190370", "R-CEL-2559580", "R-CEL-381070", "R-DME-445989", "R-DRE-975144", "R-RNO-2454202", "R-SPO-73772", "R-HSA-9717326", "R-HSA-74752", "R-BTA-69200", "R-SSC-8865999", "R-MMU-525793", "R-RNO-3769402", "R-RNO-3000170", "R-SPO-198765", "R-MMU-2559585", "R-BTA-389357", "R-HSA-163680", "R-HSA-6804116", "R-DDI-2028269", "R-HSA-1989781", "R-MMU-8985947", "R-MMU-446353", "R-MMU-204005", "R-DME-9013420", "R-HSA-6804115", "R-CEL-176187", "R-DDI-8934903", "R-MMU-113418", "R-CEL-1253288", "R-SCE-2029485", "R-DRE-194306", "R-HSA-9766229", "R-MMU-5693616", "R-MMU-1295596", "R-GGA-196299", "R-RNO-9013424", "R-DME-1307965", "R-DDI-2559582", "R-HSA-9635465", "R-MMU-9020558", "R-MMU-5628897", "R-BTA-446343", "R-DRE-2995383", "R-HSA-5210891", "R-CEL-5654693", "R-HSA-9825892", "R-CEL-190322", "R-SCE-5610787", "R-DME-112409", "R-DME-5693607", "R-HSA-3645790", "R-DRE-9013106", "R-HSA-8934903", "R-HSA-5358749", "R-HSA-8932505", "R-DME-8980692", "R-HSA-8849472", "R-HSA-975144", "R-HSA-9830364", "R-HSA-456926", "R-MMU-68962", "R-DME-69473", "R-MMU-8853659", "R-RNO-209560", "R-CEL-113418", "R-HSA-2219530", "R-HSA-6785807", "R-MMU-450520", "R-DME-5654688", "R-RNO-77387", "R-GGA-6798695", "R-BTA-170968", "R-HSA-9694631", "R-DME-354192", "R-DME-110478", "R-DRE-177929", "R-HSA-9620244", "R-RNO-1358803", "R-HSA-6791226", "R-MMU-141430", "R-HSA-5603041", "R-HSA-9860927", "R-HSA-9674555", "R-CEL-6796648", "R-HSA-445989", "R-RNO-418555", "R-DME-418592", "R-GGA-983695", "R-BTA-389356", "R-DDI-198323", "R-XTR-380270", "R-CEL-5205685", "R-MMU-174048", "R-CEL-9013149", "R-HSA-9909505", "R-MMU-4615885", "R-DME-209214", "R-HSA-167162", "R-CEL-1474228", "R-SPO-450341", "R-GGA-6811558", "R-HSA-912694", "R-RNO-6804756", "R-CFA-525793", "R-SPO-3214858", "R-MMU-936837", "R-RNO-9648002", "R-HSA-171007", "R-DME-450341", "R-DME-68949", "R-HSA-9734091", "R-DME-8856825", "R-HSA-9013420", "R-GGA-210990", "R-HSA-9662361", "R-SCE-432040", "R-HSA-9032500", "R-HSA-1660661", "R-MMU-2454202", "R-RNO-9837999", "R-CEL-418594", "R-RNO-180292", "R-DDI-5621575", "R-RNO-114604", "R-DME-9614399", "R-BTA-5218921", "R-MMU-2871809", "R-BTA-389513", "R-DDI-389357", "R-HSA-9022699", "R-DRE-6791226", "R-RNO-5675482", "R-RNO-1250196", "R-RNO-9604323", "R-PFA-164378", "R-GGA-9732724", "R-DDI-8854214", "R-HSA-879415", "R-RNO-9758274", "R-RNO-372708", "R-MMU-6811558", "R-DME-216217", "R-RNO-9020558", "R-SCE-5607761", "R-HSA-75815", "R-DME-9020558", "R-SCE-450341", "R-RNO-187042", "R-HSA-9732724", "R-GGA-354192", "R-HSA-1306955", "R-DRE-75955", "R-BTA-4420097", "R-HSA-69200", "R-MMU-112409", "R-HSA-9931530", "R-MMU-1810476", "R-DME-214869", "R-DDI-2029485", "R-DME-2029485", "R-MMU-139910", "R-DME-209459", "R-CEL-389359", "R-MMU-186763", "R-HSA-74713", "R-SPO-2514853", "R-HSA-983695", "R-HSA-5674400", "R-GGA-375165", "R-DME-5625886", "R-RNO-5696395", "R-RNO-975163", "R-HSA-9931521", "R-SCE-1474151", "R-CEL-5674135", "R-CEL-212676", "R-RNO-438066", "R-MMU-5140745", "R-HSA-8941332", "R-RNO-209543", "R-DME-6804756", "R-HSA-9820960", "R-DME-390098", "R-BTA-9732724", "R-HSA-909733", "R-BTA-2559586", "R-CEL-112382", "R-RNO-176408", "R-RNO-388844", "R-BTA-8980692", "R-SPO-73776", "R-GGA-5673000", "R-HSA-8865999", "R-MMU-5654227", "R-MMU-9645460", "R-MMU-191650", "R-RNO-69478", "R-DME-5693616", "R-DDI-442720", "R-CEL-381042", "R-SPO-5625740", "R-DME-450321", "R-XTR-2299718", "R-HSA-877312", "R-MMU-2980766", "R-HSA-2173795", "R-DME-69416", "R-BTA-5578775", "R-CEL-1474151", "R-HSA-9762114", "R-RNO-1251985", "R-SCE-163680", "R-DME-165181", "R-DME-69563", "R-HSA-167243", "R-PFA-450302", "R-SCE-9009391", "R-DME-8939236", "R-HSA-2871809", "R-CEL-380972", "R-HSA-110056", "R-DME-177929", "R-HSA-9669934", "R-BTA-418457", "R-RNO-74713", "R-MMU-2029481", "R-MMU-389513", "R-BTA-9645460", "R-HSA-9725371", "R-DRE-9009391", "R-CEL-2565942", "R-HSA-933543", "R-RNO-983695", "R-HSA-9856649", "R-MMU-198753", "R-RNO-111446", "R-RNO-68884", "R-PFA-9634597", "R-HSA-2142691", "R-SSC-9020591", "R-CEL-8980692", "R-BTA-9841922", "R-HSA-9828211", "R-XTR-5607764", "R-CEL-4419969", "R-MMU-5099900", "R-HSA-5654228", "R-RNO-416572", "R-HSA-2029481", "R-SPO-202424", "R-RNO-8983432", "R-CEL-5673001", "R-DDI-6804757", "R-BTA-75892", "R-XTR-5099900", "R-MMU-399954", "R-RNO-170968", "R-CEL-5654228", "R-HSA-9007892", "R-HSA-9673767", "R-DME-201681", "R-DRE-198753", "R-HSA-212436", "R-DME-5673000", "R-DME-5654227", "R-HSA-69563", "R-HSA-174178", "R-SPO-2730905", "R-HSA-5218900", "R-MMU-180336", "R-DRE-5654699", "R-DME-198323", "R-HSA-9020958", "R-MMU-5654720", "R-HSA-8936459", "R-HSA-77387", "R-RNO-74752", "R-MMU-6804756", "R-DDI-6782210", "R-DME-937072", "R-MMU-75035", "R-HSA-69231", "R-RNO-512988", "R-DRE-190372", "R-RNO-2871809", "R-SSC-9020933", "R-MMU-9020958", "R-MMU-201556", "R-DME-198693", "R-HSA-432040", "R-DDI-9929491", "R-HSA-5467337", "R-RNO-177504", "R-HSA-937041", "R-RNO-416476", "R-DDI-399997", "R-HSA-211733", "R-HSA-3270619", "R-MMU-176409", "R-RNO-975144", "R-HSA-9702509", "R-DDI-5673001", "R-RNO-9705462", "R-RNO-9759194", "R-XTR-380320", "R-CEL-456926", "R-SCE-1489509", "R-CEL-5654726", "R-BTA-1810476", "R-DDI-2142789", "R-MMU-5357905", "R-HSA-450604", "R-RNO-5621575", "R-SPO-432142", "R-DME-5654687", "R-DME-165159", "R-HSA-179812", "R-SCE-983231", "R-HSA-9702581", "R-RNO-2871796", "R-CEL-1227986", "R-DME-432553", "R-RNO-68875", "R-RNO-937072", "R-HSA-2514853", "R-DDI-110056", "R-BTA-5676590", "R-DME-2028269", "R-HSA-1839130", "R-MMU-5693565", "R-SCE-3928662", "R-HSA-166208", "R-CFA-201556", "R-HSA-9022535", "R-DDI-73772", "R-MMU-5654704", "R-MMU-75892", "R-RNO-8856828", "R-DDI-9634597", "R-SCE-4419969", "R-MMU-68875", "R-SSC-389513", "R-MMU-1502540", "R-MMU-3371453", "R-SCE-73779", "R-MMU-74713", "R-DME-6798695", "R-DDI-69231", "R-RNO-75955", "R-HSA-381340", "R-DME-5218900", "R-CEL-450302", "R-SPO-69017", "R-GGA-392517", "R-CEL-2454202", "R-CEL-6804757", "R-RNO-5654689", "R-RNO-3928664", "R-CEL-5693565", "R-CEL-9007892", "R-DDI-2299718", "R-MMU-77075", "R-CEL-5218921", "R-HSA-446353", "R-RNO-9762114", "R-RNO-389948", "R-MMU-1307965", "R-DME-6794361", "R-XTR-6804756", "R-HSA-1433617", "R-CEL-9762114", "R-CEL-2029485", "R-MMU-9839406", "R-RNO-9020702", "R-RNO-6807505", "R-HSA-69273", "R-CEL-9619229", "R-BTA-6798695", "R-SSC-6785807", "R-MMU-8875791", "R-DME-69478", "R-SPO-76005", "R-SPO-198323", "R-HSA-6781823", "R-RNO-912526", "R-RNO-68911", "R-MMU-5627117", "R-BTA-8853659", "R-DDI-8953750", "R-CEL-8964616", "R-SPO-163680", "R-RNO-9013404", "R-DDI-375165", "R-HSA-9013408", "R-CEL-3928662", "R-DME-5674135", "R-DME-9762114", "R-DRE-418594", "R-SSC-380972", "R-CEL-68884", "R-HSA-9632697", "R-HSA-3928664", "R-CEL-1912408", "R-DME-5140745", "R-RNO-5693607", "R-SCE-442720", "R-RNO-3928663", "R-HSA-199920", "R-DME-450520", "R-RNO-73762", "R-SSC-512988", "R-RNO-8939236", "R-CEL-8939236", "R-HSA-1660516", "R-RNO-69473", "R-RNO-1433557", "R-DME-2871796", "R-CEL-69017", "R-HSA-167200", "R-RNO-112382", "R-SSC-1632852", "R-DDI-399954", "R-MMU-176187", "R-RNO-2467813", "R-DME-68911", "R-MMU-5654710", "R-RNO-933542", "R-CEL-419037", "R-SPO-6798695", "R-RNO-176417", "R-MMU-111932", "R-DME-525793", "R-XTR-5668599", "R-CEL-1251985", "R-HSA-6794361", "R-DDI-76005", "R-HSA-9702614", "R-MMU-198203", "R-GGA-198753", "R-DRE-450341", "R-HSA-114508", "R-CFA-2565942", "R-MMU-9824585", "R-DME-190374"], "pathways": ["R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-XTR-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SPO-165158:r:Activation of AKT2", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-MMU-5635838:r:Activation of SMO", "R-DRE-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-SCE-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-373753:r:Nephrin family interactions", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SCE-445144:r:Signal transduction by L1", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CFA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-CEL-186763:r:Downstream signal transduction", "R-XTR-68884:r:Mitotic Telophase/Cytokinesis", "R-BTA-354192:r:Integrin signaling", "R-HSA-165160:r:PDE3B signalling", "R-SCE-2871796:r:FCERI mediated MAPK activation", "R-SSC-8878166:r:Transcriptional regulation by RUNX2", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-SPO-198753:r:ERK/MAPK targets", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-DDI-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-DRE-912631:r:Regulation of signaling by CBL", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-RNO-1059683:r:Interleukin-6 signaling", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-BTA-8854521:r:Interaction between PHLDA1 and AURKA", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-HSA-450341:r:Activation of the AP-1 family of transcription factors", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-RNO-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-180024:r:DARPP-32 events", "R-DRE-5675221:r:Negative regulation of MAPK pathway", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-DDI-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-DDI-198693:r:AKT phosphorylates targets in the nucleus", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-72086:r:mRNA Capping", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-8963896:r:HDL assembly", "R-SSC-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-BTA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-1483191:r:Synthesis of PC", "R-DME-201688:r:WNT mediated activation of DVL", "R-CEL-75153:r:Apoptotic execution phase", "R-PFA-5675482:r:Regulation of necroptotic cell death", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-8866376:r:Reelin signalling pathway", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-156711:r:Polo-like kinase mediated events", "R-BTA-5621480:r:Dectin-2 family", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-69541:r:Stabilization of p53", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-202424:r:Downstream TCR signaling", "R-HSA-9702600:r:midostaurin-resistant FLT3 mutants", "R-DRE-9758274:r:Regulation of NF-kappa B signaling", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-69541:r:Stabilization of p53", "R-PFA-5357905:r:Regulation of TNFR1 signaling", "R-DDI-156711:r:Polo-like kinase mediated events", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-DME-422356:r:Regulation of insulin secretion", "R-BTA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-XTR-202424:r:Downstream TCR signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-SCE-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-73728:r:RNA Polymerase I Promoter Opening", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-DME-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-449836:r:Other interleukin signaling", "R-GGA-9031628:r:NGF-stimulated transcription", "R-RNO-69563:r:p53-Dependent G1 DNA Damage Response", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-RNO-5673000:r:RAF activation", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-CEL-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-PFA-5673000:r:RAF activation", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-DME-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-SPO-2465910:r:MASTL Facilitates Mitotic Progression", "R-GGA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-937039:r:IRAK1 recruits IKK complex", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-CEL-1489509:r:DAG and IP3 signaling", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-BTA-375165:r:NCAM signaling for neurite out-growth", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9717316:r:alectinib-resistant ALK mutants", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-MMU-163615:r:PKA activation", "R-MMU-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-2029481:r:FCGR activation", "R-MMU-3928664:r:Ephrin signaling", "R-DDI-1632852:r:Macroautophagy", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-CEL-69473:r:G2/M DNA damage checkpoint", "R-BTA-3928664:r:Ephrin signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-MMU-164378:r:PKA activation in glucagon signalling", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-8875656:r:MET receptor recycling", "R-SPO-68949:r:Orc1 removal from chromatin", "R-RNO-450341:r:Activation of the AP-1 family of transcription factors", "R-BTA-8878166:r:Transcriptional regulation by RUNX2", "R-BTA-201688:r:WNT mediated activation of DVL", "R-XTR-5676590:r:NIK-->noncanonical NF-kB signaling", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-69231:r:Cyclin D associated events in G1", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-MMU-8935690:r:Digestion", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8849473:r:PTK6 Expression", "R-SCE-9634597:r:GPER1 signaling", "R-SCE-9013424:r:RHOV GTPase cycle", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-GGA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-SCE-72086:r:mRNA Capping", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-982772:r:Growth hormone receptor signaling", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-SCE-4086398:r:Ca2+ pathway", "R-DME-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-525793:r:Myogenesis", "R-CEL-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-1236394:r:Signaling by ERBB4", "R-SSC-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-390522:r:Striated Muscle Contraction", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9020702:r:Interleukin-1 signaling", "R-DME-877300:r:Interferon gamma signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-2179392:r:EGFR Transactivation by Gastrin", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-MMU-3000170:r:Syndecan interactions", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-XTR-114516:r:Disinhibition of SNARE formation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-CEL-112409:r:RAF-independent MAPK1/3 activation", "R-CEL-165159:r:MTOR signalling", "R-DME-3928664:r:Ephrin signaling", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-SPO-389359:r:CD28 dependent Vav1 pathway", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-69231:r:Cyclin D associated events in G1", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-77387:r:Insulin receptor recycling", "R-DME-538898:r:Dephosphorylation of TIM", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-PFA-5610787:r:Hedgehog 'off' state", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-SCE-69473:r:G2/M DNA damage checkpoint", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-1236974:r:ER-Phagosome pathway", "R-BTA-399719:r:Trafficking of AMPA receptors", "R-RNO-198765:r:Signalling to ERK5", "R-SSC-6806942:r:MET Receptor Activation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-CEL-199418:r:Negative regulation of the PI3K/AKT network", "R-BTA-69478:r:G2/M DNA replication checkpoint", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-GGA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-DME-1502540:r:Signaling by Activin", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-201451:r:Signaling by BMP", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-1181150:r:Signaling by NODAL", "R-HSA-68877:r:Mitotic Prometaphase", "R-CFA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-RNO-5674499:r:Negative feedback regulation of MAPK pathway", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9020558:r:Interleukin-2 signaling", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-912631:r:Regulation of signaling by CBL", "R-BTA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-8875791:r:MET activates STAT3", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SPO-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-198765:r:Signalling to ERK5", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-CEL-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-8939211:r:ESR-mediated signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-114604:r:GPVI-mediated activation cascade", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-CEL-198753:r:ERK/MAPK targets", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SPO-200425:r:Carnitine shuttle", "R-HSA-164944:r:Nef and signal transduction", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-BTA-877300:r:Interferon gamma signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-MMU-420029:r:Tight junction interactions", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-GGA-5621480:r:Dectin-2 family", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-DRE-210993:r:Tie2 Signaling", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-111995:r:phospho-PLA2 pathway", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-163615:r:PKA activation", "R-PFA-163615:r:PKA activation", "R-CEL-5627123:r:RHO GTPases activate PAKs", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-SCE-203615:r:eNOS activation", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5689603:r:UCH proteinases", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-449836:r:Other interleukin signaling", "R-SPO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-6782135:r:Dual incision in TC-NER", "R-RNO-111933:r:Calmodulin induced events", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-DRE-444257:r:RSK activation", "R-HSA-418885:r:DCC mediated attractive signaling", "R-BTA-114516:r:Disinhibition of SNARE formation", "R-DME-381042:r:PERK regulates gene expression", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-CFA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SPO-114604:r:GPVI-mediated activation cascade", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-PFA-9833482:r:PKR-mediated signaling", "R-RNO-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-SPO-525793:r:Myogenesis", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-DRE-9013408:r:RHOG GTPase cycle", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-GGA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-BTA-8849470:r:PTK6 Regulates Cell Cycle", "R-BTA-381042:r:PERK regulates gene expression", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-69563:r:p53-Dependent G1 DNA Damage Response", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68911:r:G2 Phase", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-203615:r:eNOS activation", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-BTA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DDI-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-381042:r:PERK regulates gene expression", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-DRE-190373:r:FGFR1c ligand binding and activation", "R-DME-8878166:r:Transcriptional regulation by RUNX2", "R-CFA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-432142:r:Platelet sensitization by LDL", "R-DRE-210990:r:PECAM1 interactions", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-GGA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-418555:r:G alpha (s) signalling events", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-3642279:r:TGFBR2 MSI Frameshift Mutants in Cancer", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-SPO-156711:r:Polo-like kinase mediated events", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-BTA-2028269:r:Signaling by Hippo", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-1489509:r:DAG and IP3 signaling", "R-CEL-1632852:r:Macroautophagy", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-418885:r:DCC mediated attractive signaling", "R-RNO-2672351:r:Stimuli-sensing channels", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DME-209159:r:Assembly of the CI containing complexes", "R-BTA-5654732:r:Negative regulation of FGFR3 signaling", "R-DDI-2871796:r:FCERI mediated MAPK activation", "R-DDI-164378:r:PKA activation in glucagon signalling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-PFA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-163358:r:PKA-mediated phosphorylation of key metabolic factors", "R-HSA-354192:r:Integrin signaling", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SSC-6807004:r:Negative regulation of MET activity", "R-MMU-156711:r:Polo-like kinase mediated events", "R-SSC-9020956:r:Interleukin-27 signaling", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-6794361:r:Neurexins and neuroligins", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-XTR-68877:r:Mitotic Prometaphase", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-389356:r:Co-stimulation by CD28", "R-HSA-1236394:r:Signaling by ERBB4", "R-BTA-1433559:r:Regulation of KIT signaling", "R-MMU-8963896:r:HDL assembly", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-422356:r:Regulation of insulin secretion", "R-DRE-1295596:r:Spry regulation of FGF signaling", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-176417:r:Phosphorylation of Emi1", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-XTR-1169091:r:Activation of NF-kappaB in B cells", "R-SSC-1433559:r:Regulation of KIT signaling", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-SPO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-5610787:r:Hedgehog 'off' state", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-211163:r:AKT-mediated inactivation of FOXO1A", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-MMU-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-HSA-203615:r:eNOS activation", "R-DME-68962:r:Activation of the pre-replicative complex", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-BTA-68875:r:Mitotic Prophase", "R-SSC-210990:r:PECAM1 interactions", "R-CEL-4086398:r:Ca2+ pathway", "R-SPO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-1236394:r:Signaling by ERBB4", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-170984:r:ARMS-mediated activation", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-69478:r:G2/M DNA replication checkpoint", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-392517:r:Rap1 signalling", "R-SPO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-SPO-5610787:r:Hedgehog 'off' state", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-203615:r:eNOS activation", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-DME-216083:r:Integrin cell surface interactions", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-69416:r:Dimerization of procaspase-8", "R-SCE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-XTR-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-DRE-9013026:r:RHOB GTPase cycle", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-SCE-114604:r:GPVI-mediated activation cascade", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CEL-2024096:r:HS-GAG degradation", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-68884:r:Mitotic Telophase/Cytokinesis", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-201451:r:Signaling by BMP", "R-CEL-164378:r:PKA activation in glucagon signalling", "R-CEL-171007:r:p38MAPK events", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9706369:r:Negative regulation of FLT3", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-9833482:r:PKR-mediated signaling", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-180292:r:GAB1 signalosome", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DRE-420029:r:Tight junction interactions", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DME-8934903:r:Receptor Mediated Mitophagy", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9842663:r:Signaling by LTK", "R-SPO-180024:r:DARPP-32 events", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CEL-2672351:r:Stimuli-sensing channels", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-877300:r:Interferon gamma signaling", "R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-DRE-1266695:r:Interleukin-7 signaling", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-BTA-9627069:r:Regulation of the apoptosome activity", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-170968:r:Frs2-mediated activation", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-DME-3371571:r:HSF1-dependent transactivation", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-XTR-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-DDI-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-373753:r:Nephrin family interactions", "R-DDI-444257:r:RSK activation", "R-MMU-180292:r:GAB1 signalosome", "R-DME-437239:r:Recycling pathway of L1", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-210993:r:Tie2 Signaling", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-DDI-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-196299:r:Beta-catenin phosphorylation cascade", "R-SPO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DRE-354192:r:Integrin signaling", "R-XTR-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-5635838:r:Activation of SMO", "R-DME-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-8854521:r:Interaction between PHLDA1 and AURKA", "R-SPO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-DDI-9031628:r:NGF-stimulated transcription", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-1489509:r:DAG and IP3 signaling", "R-BTA-5673000:r:RAF activation", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-BTA-5654726:r:Negative regulation of FGFR1 signaling", "R-SCE-6782135:r:Dual incision in TC-NER", "R-RNO-432142:r:Platelet sensitization by LDL", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-109704:r:PI3K Cascade", "R-BTA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-RNO-68881:r:Mitotic Metaphase/Anaphase Transition", "R-RNO-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-CEL-68911:r:G2 Phase", "R-HSA-525793:r:Myogenesis", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-389948:r:Co-inhibition by PD-1", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-9645135:r:STAT5 Activation", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-GGA-389356:r:Co-stimulation by CD28", "R-SCE-2559580:r:Oxidative Stress Induced Senescence", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-DME-180024:r:DARPP-32 events", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DME-209397:r:Formation of the cytosolic BSK 'scaffolding complex'", "R-DDI-8963896:r:HDL assembly", "R-DDI-202670:r:ERKs are inactivated", "R-BTA-180024:r:DARPP-32 events", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-5603027:r:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "R-CEL-5578775:r:Ion homeostasis", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-8875656:r:MET receptor recycling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-DME-176417:r:Phosphorylation of Emi1", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-418885:r:DCC mediated attractive signaling", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-186797:r:Signaling by PDGF", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-BTA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-5673000:r:RAF activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-8854521:r:Interaction between PHLDA1 and AURKA", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5673000:r:RAF activation", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DDI-445144:r:Signal transduction by L1", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-DME-390023:r:Subcellular localisation of D", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-XTR-176417:r:Phosphorylation of Emi1", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SPO-9031628:r:NGF-stimulated transcription", "R-SSC-389356:r:Co-stimulation by CD28", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-MMU-9031628:r:NGF-stimulated transcription", "R-BTA-450341:r:Activation of the AP-1 family of transcription factors", "R-CEL-9648002:r:RAS processing", "R-DME-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-PFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-GGA-199920:r:CREB phosphorylation", "R-DRE-430116:r:GP1b-IX-V activation signalling", "R-HSA-9703009:r:tamatinib-resistant FLT3 mutants", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-1502540:r:Signaling by Activin", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-68884:r:Mitotic Telophase/Cytokinesis", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-DME-418555:r:G alpha (s) signalling events", "R-CFA-9851151:r:MDK and PTN in ALK signaling", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-CEL-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-HSA-4086398:r:Ca2+ pathway", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SPO-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-216119:r:Activation of CI", "R-CEL-193648:r:NRAGE signals death through JNK", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-XTR-1295596:r:Spry regulation of FGF signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-109704:r:PI3K Cascade", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-MMU-176417:r:Phosphorylation of Emi1", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-SSC-8875555:r:MET activates RAP1 and RAC1", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-392517:r:Rap1 signalling", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-198753:r:ERK/MAPK targets", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-XTR-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-PFA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-201556:r:Signaling by ALK", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-HSA-9702569:r:KW2449-resistant FLT3 mutants", "R-CEL-166208:r:mTORC1-mediated signalling", "R-MMU-74749:r:Signal attenuation", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-9607240:r:FLT3 Signaling", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-CEL-912631:r:Regulation of signaling by CBL", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-MMU-69541:r:Stabilization of p53", "R-MMU-381042:r:PERK regulates gene expression", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-392517:r:Rap1 signalling", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-1433559:r:Regulation of KIT signaling", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-177929:r:Signaling by EGFR", "R-BTA-2514853:r:Condensation of Prometaphase Chromosomes", "R-DME-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-MMU-8939211:r:ESR-mediated signaling", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-199920:r:CREB phosphorylation", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SSC-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-72086:r:mRNA Capping", "R-PFA-5213460:r:RIPK1-mediated regulated necrosis", "R-BTA-912631:r:Regulation of signaling by CBL", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-420029:r:Tight junction interactions", "R-MMU-69478:r:G2/M DNA replication checkpoint", "R-DRE-5654710:r:PI-3K cascade:FGFR3", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-GGA-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-DME-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SPO-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-201688:r:WNT mediated activation of DVL", "R-MMU-203615:r:eNOS activation", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-72086:r:mRNA Capping", "R-DDI-176187:r:Activation of ATR in response to replication stress", "R-MMU-9619229:r:Activation of RAC1 downstream of NMDARs", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-SSC-2559585:r:Oncogene Induced Senescence", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CFA-1433559:r:Regulation of KIT signaling", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-9013106:r:RHOC GTPase cycle", "R-SCE-381070:r:IRE1alpha activates chaperones", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9652169:r:Signaling by MAP2K mutants", "R-SSC-399956:r:CRMPs in Sema3A signaling", "R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-392517:r:Rap1 signalling", "R-CEL-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-RNO-8935690:r:Digestion", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-SCE-198765:r:Signalling to ERK5", "R-SCE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-HSA-176034:r:Interactions of Tat with host cellular proteins", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-DRE-416476:r:G alpha (q) signalling events", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-MMU-9008059:r:Interleukin-37 signaling", "R-HSA-2028269:r:Signaling by Hippo", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-3295583:r:TRP channels", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-RNO-190322:r:FGFR4 ligand binding and activation", "R-CEL-444257:r:RSK activation", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-BTA-5689880:r:Ub-specific processing proteases", "R-RNO-1483191:r:Synthesis of PC", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-HSA-198745:r:Signalling to STAT3", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-CEL-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-2559585:r:Oncogene Induced Senescence", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-210990:r:PECAM1 interactions", "R-SSC-912631:r:Regulation of signaling by CBL", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-SCE-166208:r:mTORC1-mediated signalling", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-202670:r:ERKs are inactivated", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-168638:r:NOD1/2 Signaling Pathway", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-1632852:r:Macroautophagy", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DRE-1227986:r:Signaling by ERBB2", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-68911:r:G2 Phase", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-9634597:r:GPER1 signaling", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-BTA-982772:r:Growth hormone receptor signaling", "R-BTA-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-SSC-373753:r:Nephrin family interactions", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-2672351:r:Stimuli-sensing channels", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-HSA-912446:r:Meiotic recombination", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-381070:r:IRE1alpha activates chaperones", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-CEL-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-DDI-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-XTR-9833482:r:PKR-mediated signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SSC-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-CFA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SCE-156711:r:Polo-like kinase mediated events", "R-MMU-9696273:r:RND1 GTPase cycle", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-2871837:r:FCERI mediated NF-kB activation", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-69231:r:Cyclin D associated events in G1", "R-DME-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-877300:r:Interferon gamma signaling", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-165158:r:Activation of AKT2", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-165159:r:MTOR signalling", "R-BTA-2980766:r:Nuclear Envelope Breakdown", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-171319:r:Telomere Extension By Telomerase", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-1632852:r:Macroautophagy", "R-MMU-76005:r:Response to elevated platelet cytosolic Ca2+", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-DDI-5625740:r:RHO GTPases activate PKNs", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-HSA-9632700:r:Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6", "R-BTA-198765:r:Signalling to ERK5", "R-HSA-3371378:r:Regulation by c-FLIP", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-SCE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-PFA-5689880:r:Ub-specific processing proteases", "R-SPO-163615:r:PKA activation", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-211736:r:Stimulation of the cell death response by PAK-2p34", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-877312:r:Regulation of IFNG signaling", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-DDI-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-8852405:r:Signaling by MST1", "R-DME-163615:r:PKA activation", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-75153:r:Apoptotic execution phase", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-180024:r:DARPP-32 events", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-171007:r:p38MAPK events", "R-HSA-216083:r:Integrin cell surface interactions", "R-DDI-3295583:r:TRP channels", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-5578775:r:Ion homeostasis", "R-RNO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-SPO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-HSA-111995:r:phospho-PLA2 pathway", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-SSC-200425:r:Carnitine shuttle", "R-SCE-114508:r:Effects of PIP2 hydrolysis", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-8939211:r:ESR-mediated signaling", "R-RNO-9839406:r:TGFBR3 regulates activin signaling", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-XTR-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-3928664:r:Ephrin signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-1483191:r:Synthesis of PC", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DRE-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-525793:r:Myogenesis", "R-HSA-6806942:r:MET Receptor Activation", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-DRE-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-390150:r:DS ligand bound to FT receptor", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-68881:r:Mitotic Metaphase/Anaphase Transition", "R-SPO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-MMU-1489509:r:DAG and IP3 signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-CFA-112411:r:MAPK1 (ERK2) activation", "R-SPO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-5578768:r:Physiological factors", "R-HSA-198753:r:ERK/MAPK targets", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-CEL-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-9702590:r:gilteritinib-resistant FLT3 mutants", "R-RNO-180024:r:DARPP-32 events", "R-DDI-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-69416:r:Dimerization of procaspase-8", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-9648002:r:RAS processing", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-389359:r:CD28 dependent Vav1 pathway", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-SPO-2871796:r:FCERI mediated MAPK activation", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9931529:r:Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK", "R-DDI-69202:r:Cyclin E associated events during G1/S transition", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-BTA-2424491:r:DAP12 signaling", "R-SSC-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-8849470:r:PTK6 Regulates Cell Cycle", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-CEL-9616222:r:Transcriptional regulation of granulopoiesis", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-DME-209396:r:Phosphorylation of ARM", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DME-209387:r:Phosphorylation of ARR", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SSC-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-9702636:r:tandutinib-resistant FLT3 mutants", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-XTR-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-1170546:r:Prolactin receptor signaling", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-SPO-114508:r:Effects of PIP2 hydrolysis", "R-DDI-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-PFA-9837999:r:Mitochondrial protein degradation", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-HSA-9717319:r:brigatinib-resistant ALK mutants", "R-CEL-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-203615:r:eNOS activation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-68884:r:Mitotic Telophase/Cytokinesis", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-450341:r:Activation of the AP-1 family of transcription factors", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-373752:r:Netrin-1 signaling", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-HSA-73728:r:RNA Polymerase I Promoter Opening", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-SPO-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-CEL-110056:r:MAPK3 (ERK1) activation", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-6783783:r:Interleukin-10 signaling", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-75893:r:TNF signaling", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-1236394:r:Signaling by ERBB4", "R-DRE-432142:r:Platelet sensitization by LDL", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-CEL-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-445144:r:Signal transduction by L1", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-GGA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9702998:r:linifanib-resistant FLT3 mutants", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-190370:r:FGFR1b ligand binding and activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-422356:r:Regulation of insulin secretion", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DDI-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-RNO-3295583:r:TRP channels", "R-CFA-5674135:r:MAP2K and MAPK activation", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-RNO-373752:r:Netrin-1 signaling", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-DRE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-170984:r:ARMS-mediated activation", "R-RNO-8932505:r:DAG1 core M3 glycosylations", "R-HSA-211163:r:AKT-mediated inactivation of FOXO1A", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DDI-112411:r:MAPK1 (ERK2) activation", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-201688:r:WNT mediated activation of DVL", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-112409:r:RAF-independent MAPK1/3 activation", "R-SSC-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-75153:r:Apoptotic execution phase", "R-SPO-203615:r:eNOS activation", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-XTR-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SSC-8875791:r:MET activates STAT3", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-373753:r:Nephrin family interactions", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-432142:r:Platelet sensitization by LDL", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-DDI-180024:r:DARPP-32 events", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-HSA-420029:r:Tight junction interactions", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-912631:r:Regulation of signaling by CBL", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-CFA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-CEL-202670:r:ERKs are inactivated", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-SCE-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-8866376:r:Reelin signalling pathway", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-164378:r:PKA activation in glucagon signalling", "R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DME-210991:r:Basigin interactions", "R-GGA-9839406:r:TGFBR3 regulates activin signaling", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-1538133:r:G0 and Early G1", "R-CEL-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-9008059:r:Interleukin-37 signaling", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-CEL-6782135:r:Dual incision in TC-NER", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-BTA-164378:r:PKA activation in glucagon signalling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-170984:r:ARMS-mediated activation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-68911:r:G2 Phase", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SCE-429947:r:Deadenylation of mRNA", "R-HSA-9702620:r:quizartinib-resistant FLT3 mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-191650:r:Regulation of gap junction activity", "R-SPO-69473:r:G2/M DNA damage checkpoint", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-SPO-166208:r:mTORC1-mediated signalling", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-418457:r:cGMP effects", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-CEL-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9717329:r:lorlatinib-resistant ALK mutants", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-DDI-163615:r:PKA activation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-432490:r:Nuclear import of PER and TIM", "R-CEL-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-202670:r:ERKs are inactivated", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-CEL-2871796:r:FCERI mediated MAPK activation", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DDI-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DRE-9851151:r:MDK and PTN in ALK signaling", "R-RNO-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-DME-9833482:r:PKR-mediated signaling", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DDI-4086398:r:Ca2+ pathway", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-1433559:r:Regulation of KIT signaling", "R-SCE-163615:r:PKA activation", "R-MMU-111995:r:phospho-PLA2 pathway", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-BTA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-BTA-202670:r:ERKs are inactivated", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-9634597:r:GPER1 signaling", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9717301:r:NVP-TAE684-resistant ALK mutants", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-68875:r:Mitotic Prophase", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-CEL-450341:r:Activation of the AP-1 family of transcription factors", "R-CEL-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9630791:r:Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-BTA-156711:r:Polo-like kinase mediated events", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DRE-9020702:r:Interleukin-1 signaling", "R-DRE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-RNO-8865999:r:MET activates PTPN11", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-CEL-525793:r:Myogenesis", "R-CEL-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-SCE-432142:r:Platelet sensitization by LDL", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5578768:r:Physiological factors", "R-CEL-180292:r:GAB1 signalosome", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-SSC-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-MMU-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-CEL-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-DDI-203615:r:eNOS activation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-5674499:r:Negative feedback regulation of MAPK pathway", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-381042:r:PERK regulates gene expression", "R-RNO-6794361:r:Neurexins and neuroligins", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-XTR-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-444257:r:RSK activation", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-DRE-9842663:r:Signaling by LTK", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-69473:r:G2/M DNA damage checkpoint", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1502540:r:Signaling by Activin", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-5578768:r:Physiological factors", "R-BTA-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DRE-449836:r:Other interleukin signaling", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-2465910:r:MASTL Facilitates Mitotic Progression", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-171007:r:p38MAPK events", "R-DME-170968:r:Frs2-mediated activation", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-RNO-186797:r:Signaling by PDGF", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-RNO-9007892:r:Interleukin-38 signaling", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-444257:r:RSK activation", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-2514853:r:Condensation of Prometaphase Chromosomes", "R-SCE-444257:r:RSK activation", "R-SSC-8875656:r:MET receptor recycling", "R-SPO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-210993:r:Tie2 Signaling", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-2299718:r:Condensation of Prophase Chromosomes", "R-DDI-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-8854214:r:TBC/RABGAPs", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9702632:r:sunitinib-resistant FLT3 mutants", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-3371378:r:Regulation by c-FLIP", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-CEL-3000170:r:Syndecan interactions", "R-SPO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-209209:r:Formation of the activated receptor complex", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-SCE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-PFA-5689896:r:Ovarian tumor domain proteases", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-PFA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DRE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-202670:r:ERKs are inactivated", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-CEL-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-CFA-198753:r:ERK/MAPK targets", "R-CEL-180024:r:DARPP-32 events", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-164378:r:PKA activation in glucagon signalling", "R-DME-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-DME-112411:r:MAPK1 (ERK2) activation", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-201451:r:Signaling by BMP", "R-DDI-3899300:r:SUMOylation of transcription cofactors", "R-BTA-202433:r:Generation of second messenger molecules", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DME-392517:r:Rap1 signalling", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-354192:r:Integrin signaling", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-373752:r:Netrin-1 signaling", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-1538133:r:G0 and Early G1", "R-BTA-437239:r:Recycling pathway of L1", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-418457:r:cGMP effects", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-BTA-1538133:r:G0 and Early G1", "R-DRE-9031628:r:NGF-stimulated transcription", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-936837:r:Ion transport by P-type ATPases", "R-RNO-139910:r:Activation of BMF and translocation to mitochondria", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-156711:r:Polo-like kinase mediated events", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-176412:r:Phosphorylation of the APC/C", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-BTA-111933:r:Calmodulin induced events", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-75153:r:Apoptotic execution phase", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-SPO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-DRE-8874081:r:MET activates PTK2 signaling", "R-SCE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-444257:r:RSK activation", "R-HSA-187024:r:NGF-independant TRKA activation", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-SPO-75153:r:Apoptotic execution phase", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-186797:r:Signaling by PDGF", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-9020702:r:Interleukin-1 signaling", "R-BTA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-199920:r:CREB phosphorylation", "R-HSA-187042:r:TRKA activation by NGF", "R-BTA-9013424:r:RHOV GTPase cycle", "R-CEL-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-8866376:r:Reelin signalling pathway", "R-MMU-9020933:r:Interleukin-23 signaling", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DDI-9020702:r:Interleukin-1 signaling", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-9013420:r:RHOU GTPase cycle", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-CEL-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-1538133:r:G0 and Early G1", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-1227986:r:Signaling by ERBB2", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-9007892:r:Interleukin-38 signaling", "R-RNO-8853659:r:RET signaling", "R-CEL-177929:r:Signaling by EGFR", "R-CEL-9833482:r:PKR-mediated signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-PFA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-BTA-416476:r:G alpha (q) signalling events", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DME-399997:r:Acetylcholine regulates insulin secretion", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-1483191:r:Synthesis of PC", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-SPO-429947:r:Deadenylation of mRNA", "R-CEL-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-GGA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-CEL-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-SCE-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-68881:r:Mitotic Metaphase/Anaphase Transition", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DDI-381070:r:IRE1alpha activates chaperones", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-DME-77387:r:Insulin receptor recycling", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-432142:r:Platelet sensitization by LDL", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-CEL-68949:r:Orc1 removal from chromatin", "R-SCE-525793:r:Myogenesis", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-176412:r:Phosphorylation of the APC/C", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-166208:r:mTORC1-mediated signalling", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-SCE-2871837:r:FCERI mediated NF-kB activation", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SCE-164378:r:PKA activation in glucagon signalling", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-CFA-450341:r:Activation of the AP-1 family of transcription factors", "R-CEL-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-RNO-2028269:r:Signaling by Hippo", "R-BTA-1227986:r:Signaling by ERBB2", "R-MMU-1632852:r:Macroautophagy", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-8963896:r:HDL assembly", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-PFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-PFA-180024:r:DARPP-32 events", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-DDI-198753:r:ERK/MAPK targets", "R-DME-211163:r:AKT-mediated inactivation of FOXO1A", "R-CEL-182971:r:EGFR downregulation", "R-SCE-200425:r:Carnitine shuttle", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-165159:r:MTOR signalling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-DME-9607240:r:FLT3 Signaling", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-170968:r:Frs2-mediated activation", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DRE-186763:r:Downstream signal transduction", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-RNO-202670:r:ERKs are inactivated", "R-DDI-111995:r:phospho-PLA2 pathway", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-389356:r:Co-stimulation by CD28", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-171007:r:p38MAPK events", "R-DME-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-390089:r:Formation of the Hippo kinase cassette", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-9013420:r:RHOU GTPase cycle", "R-CEL-9031628:r:NGF-stimulated transcription", "R-DME-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-198693:r:AKT phosphorylates targets in the nucleus", "R-RNO-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-DME-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-DRE-109704:r:PI3K Cascade", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9824272:r:Somitogenesis", "R-RNO-199920:r:CREB phosphorylation", "R-SCE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-166208:r:mTORC1-mediated signalling", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-429947:r:Deadenylation of mRNA", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-111446:r:Activation of BIM and translocation to mitochondria", "R-DDI-112409:r:RAF-independent MAPK1/3 activation", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-SCE-75153:r:Apoptotic execution phase", "R-HSA-8852405:r:Signaling by MST1", "R-DRE-2028269:r:Signaling by Hippo", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-BTA-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DME-74749:r:Signal attenuation", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DDI-4419969:r:Depolymerization of the Nuclear Lamina", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1181150:r:Signaling by NODAL", "R-DDI-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-BTA-210993:r:Tie2 Signaling", "R-DME-9007892:r:Interleukin-38 signaling", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-193648:r:NRAGE signals death through JNK", "R-HSA-169131:r:Inhibition of PKR", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-HSA-68881:r:Mitotic Metaphase/Anaphase Transition", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-8866376:r:Reelin signalling pathway", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-8939211:r:ESR-mediated signaling", "R-BTA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DDI-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-187042:r:TRKA activation by NGF", "R-RNO-73728:r:RNA Polymerase I Promoter Opening", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-SPO-72086:r:mRNA Capping", "R-CEL-8854214:r:TBC/RABGAPs", "R-SSC-3371571:r:HSF1-dependent transactivation", "R-HSA-1266695:r:Interleukin-7 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-SSC-3214858:r:RMTs methylate histone arginines", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-DRE-1253288:r:Downregulation of ERBB4 signaling", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-CFA-5673000:r:RAF activation", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5602636:r:IKBKB deficiency causes SCID", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-8963896:r:HDL assembly", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-SSC-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-SSC-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-CEL-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-PFA-381042:r:PERK regulates gene expression", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-HSA-9702605:r:pexidartinib-resistant FLT3 mutants", "R-MMU-9648002:r:RAS processing", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-416476:r:G alpha (q) signalling events", "R-DRE-9833482:r:PKR-mediated signaling", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-5635838:r:Activation of SMO", "R-BTA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-RNO-200425:r:Carnitine shuttle", "R-RNO-9619229:r:Activation of RAC1 downstream of NMDARs", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-DDI-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-XTR-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-8851805:r:MET activates RAS signaling", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-BTA-9013420:r:RHOU GTPase cycle", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-2028269:r:Signaling by Hippo", "R-CEL-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-SSC-2424491:r:DAP12 signaling", "R-BTA-74749:r:Signal attenuation", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-DME-3000170:r:Syndecan interactions", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-165159:r:MTOR signalling", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-SSC-5673000:r:RAF activation", "R-GGA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-8849470:r:PTK6 Regulates Cell Cycle", "R-SCE-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-RNO-111995:r:phospho-PLA2 pathway", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DDI-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9607240:r:FLT3 Signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-5673000:r:RAF activation", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-9634597:r:GPER1 signaling", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-MMU-211163:r:AKT-mediated inactivation of FOXO1A", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-2465910:r:MASTL Facilitates Mitotic Progression", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-8942233:r:Intestinal infectious diseases", "R-SSC-982772:r:Growth hormone receptor signaling", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-DME-164378:r:PKA activation in glucagon signalling", "R-BTA-70221:r:Glycogen breakdown (glycogenolysis)", "R-DME-198753:r:ERK/MAPK targets", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-MMU-9007892:r:Interleukin-38 signaling", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-CFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-156711:r:Polo-like kinase mediated events", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9609690:r:HCMV Early Events", "R-GGA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-8851805:r:MET activates RAS signaling", "R-MMU-1912408:r:Pre-NOTCH Transcription and Translation", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9648002:r:RAS processing", "R-CEL-165158:r:Activation of AKT2", "R-BTA-9833482:r:PKR-mediated signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-2871796:r:FCERI mediated MAPK activation", "R-SCE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SCE-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-BTA-1181150:r:Signaling by NODAL", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-8874081:r:MET activates PTK2 signaling", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-111933:r:Calmodulin induced events", "R-MMU-198765:r:Signalling to ERK5", "R-MMU-165158:r:Activation of AKT2", "R-SPO-164378:r:PKA activation in glucagon signalling", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-DRE-114516:r:Disinhibition of SNARE formation", "R-DME-389513:r:Co-inhibition by CTLA4", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-69231:r:Cyclin D associated events in G1", "R-CEL-77387:r:Insulin receptor recycling", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-200425:r:Carnitine shuttle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-CFA-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-182971:r:EGFR downregulation", "R-DDI-1538133:r:G0 and Early G1", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-SSC-8854521:r:Interaction between PHLDA1 and AURKA", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-373753:r:Nephrin family interactions", "R-HSA-432142:r:Platelet sensitization by LDL", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-5635838:r:Activation of SMO", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-75893:r:TNF signaling", "R-DRE-191650:r:Regulation of gap junction activity", "R-DME-9749641:r:Aspirin ADME", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-DME-1266695:r:Interleukin-7 signaling", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-392517:r:Rap1 signalling", "R-HSA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-SSC-877300:r:Interferon gamma signaling", "R-HSA-9613354:r:Lipophagy", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DRE-5654727:r:Negative regulation of FGFR2 signaling", "R-PFA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-GGA-201451:r:Signaling by BMP", "R-HSA-8854521:r:Interaction between PHLDA1 and AURKA", "R-DME-202670:r:ERKs are inactivated", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-CEL-202424:r:Downstream TCR signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-165158:r:Activation of AKT2", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-8948751:r:Regulation of PTEN stability and activity", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9669933:r:Signaling by kinase domain mutants of KIT", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-RNO-9696270:r:RND2 GTPase cycle", "R-DME-209425:r:Transcriptional activtion by AP-1 transcription factor", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-199920:r:CREB phosphorylation", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-68875:r:Mitotic Prophase", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-SSC-3928664:r:Ephrin signaling", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-BTA-165158:r:Activation of AKT2", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9630794:r:Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-383280:r:Nuclear Receptor transcription pathway", "R-MMU-877300:r:Interferon gamma signaling", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-112409:r:RAF-independent MAPK1/3 activation", "R-GGA-1433559:r:Regulation of KIT signaling", "R-DDI-165158:r:Activation of AKT2", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-CFA-8854518:r:AURKA Activation by TPX2", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-198753:r:ERK/MAPK targets", "R-SCE-198753:r:ERK/MAPK targets", "R-DRE-525793:r:Myogenesis", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-9031628:r:NGF-stimulated transcription", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9702624:r:sorafenib-resistant FLT3 mutants", "R-RNO-156711:r:Polo-like kinase mediated events", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DME-390178:r:DS ligand not bound to FT receptor", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DME-209409:r:Formation of the nuclear AP-1 transcription factor 'scaffolding complex'", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-RNO-193648:r:NRAGE signals death through JNK", "R-CFA-4086398:r:Ca2+ pathway", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DME-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-200425:r:Carnitine shuttle", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-5673000:r:RAF activation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DRE-5673000:r:RAF activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-BTA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-3371571:r:HSF1-dependent transactivation", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-8935690:r:Digestion", "R-DRE-201556:r:Signaling by ALK", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DME-110056:r:MAPK3 (ERK1) activation", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-GGA-1502540:r:Signaling by Activin", "R-BTA-163615:r:PKA activation", "R-GGA-265976:r:Homologous DNA pairing and strand exchange", "R-DDI-200425:r:Carnitine shuttle", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-1489509:r:DAG and IP3 signaling", "R-MMU-418594:r:G alpha (i) signalling events", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-69563:r:p53-Dependent G1 DNA Damage Response", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-877300:r:Interferon gamma signaling", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-RNO-177929:r:Signaling by EGFR", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-SCE-9031628:r:NGF-stimulated transcription", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-PFA-430116:r:GP1b-IX-V activation signalling", "R-HSA-3000170:r:Syndecan interactions", "R-DME-5578775:r:Ion homeostasis", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-109704:r:PI3K Cascade", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-DDI-9648002:r:RAS processing", "R-SCE-6811555:r:PI5P Regulates TP53 Acetylation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-CFA-8854521:r:Interaction between PHLDA1 and AURKA", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-170968:r:Frs2-mediated activation", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-428540:r:Activation of RAC1", "R-DME-68881:r:Mitotic Metaphase/Anaphase Transition", "R-SCE-389359:r:CD28 dependent Vav1 pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-DME-8939211:r:ESR-mediated signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-5621480:r:Dectin-2 family", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-74752:r:Signaling by Insulin receptor", "R-SCE-180024:r:DARPP-32 events", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-BTA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SPO-4086398:r:Ca2+ pathway", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-9706369:r:Negative regulation of FLT3", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DRE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-139910:r:Activation of BMF and translocation to mitochondria", "R-DME-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-CEL-163615:r:PKA activation", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1502540:r:Signaling by Activin", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-3371378:r:Regulation by c-FLIP", "R-DME-171007:r:p38MAPK events", "R-SSC-9759194:r:Nuclear events mediated by NFE2L2", "R-GGA-430116:r:GP1b-IX-V activation signalling", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-GGA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-165158:r:Activation of AKT2", "R-CEL-8849472:r:PTK6 Down-Regulation", "R-HSA-167044:r:Signalling to RAS", "R-DRE-171007:r:p38MAPK events", "R-CEL-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-9018519:r:Estrogen-dependent gene expression", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-DME-430116:r:GP1b-IX-V activation signalling", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-9842663:r:Signaling by LTK", "R-CEL-1483191:r:Synthesis of PC", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-GGA-5635838:r:Activation of SMO", "R-BTA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-209190:r:Phosphorylation of CI", "R-DME-180292:r:GAB1 signalosome", "R-CEL-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-1266695:r:Interleukin-7 signaling", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-6794361:r:Neurexins and neuroligins", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-1227986:r:Signaling by ERBB2", "R-RNO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-GGA-69473:r:G2/M DNA damage checkpoint", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-4086398:r:Ca2+ pathway", "R-CEL-2028269:r:Signaling by Hippo", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-GGA-2672351:r:Stimuli-sensing channels", "R-DME-114516:r:Disinhibition of SNARE formation", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-8866376:r:Reelin signalling pathway", "R-SSC-399719:r:Trafficking of AMPA receptors", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-449836:r:Other interleukin signaling", "R-SCE-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-3295583:r:TRP channels", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-CEL-1181150:r:Signaling by NODAL", "R-BTA-446353:r:Cell-extracellular matrix interactions", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-4086398:r:Ca2+ pathway", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9702596:r:lestaurtinib-resistant FLT3 mutants", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-373753:r:Nephrin family interactions", "R-HSA-381042:r:PERK regulates gene expression", "R-RNO-877312:r:Regulation of IFNG signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DME-5610787:r:Hedgehog 'off' state", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-SPO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-6806942:r:MET Receptor Activation", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-DME-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-176412:r:Phosphorylation of the APC/C", "R-RNO-445144:r:Signal transduction by L1", "R-SSC-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-429947:r:Deadenylation of mRNA", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-DME-8985947:r:Interleukin-9 signaling", "R-DME-68884:r:Mitotic Telophase/Cytokinesis", "R-CFA-445144:r:Signal transduction by L1", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-XTR-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9696264:r:RND3 GTPase cycle", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-HSA-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-111933:r:Calmodulin induced events", "R-DRE-8983432:r:Interleukin-15 signaling", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-182971:r:EGFR downregulation", "R-CEL-170968:r:Frs2-mediated activation", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-8985947:r:Interleukin-9 signaling", "R-DME-373752:r:Netrin-1 signaling", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-HSA-8854214:r:TBC/RABGAPs", "R-DDI-165159:r:MTOR signalling", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-PFA-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-111446:r:Activation of BIM and translocation to mitochondria", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-RNO-445355:r:Smooth Muscle Contraction", "R-CEL-5610787:r:Hedgehog 'off' state", "R-DME-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-9674404:r:Sorafenib-resistant PDGFR mutants", "R-CEL-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-9717323:r:ceritinib-resistant ALK mutants", "R-BTA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-XTR-1538133:r:G0 and Early G1", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-DRE-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-SPO-69231:r:Cyclin D associated events in G1", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-BTA-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-8878166:r:Transcriptional regulation by RUNX2", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-RNO-1181150:r:Signaling by NODAL", "R-CEL-69478:r:G2/M DNA replication checkpoint", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DME-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-MMU-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-373753:r:Nephrin family interactions", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-422356:r:Regulation of insulin secretion", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-SPO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SCE-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SSC-399954:r:Sema3A PAK dependent Axon repulsion", "R-SSC-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-9020956:r:Interleukin-27 signaling", "R-BTA-68911:r:G2 Phase", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-418457:r:cGMP effects", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-190370:r:FGFR1b ligand binding and activation", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-SCE-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-201556:r:Signaling by ALK", "R-BTA-9013407:r:RHOH GTPase cycle", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SPO-9634597:r:GPER1 signaling", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-111933:r:Calmodulin induced events", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DDI-68949:r:Orc1 removal from chromatin", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SPO-202670:r:ERKs are inactivated", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-201688:r:WNT mediated activation of DVL", "R-BTA-9766229:r:Degradation of CDH1", "R-CEL-201681:r:TCF dependent signaling in response to WNT", "R-SPO-444257:r:RSK activation", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-SCE-168638:r:NOD1/2 Signaling Pathway", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-CEL-72086:r:mRNA Capping", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-SCE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DRE-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9833110:r:RSV-host interactions", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-DME-1489509:r:DAG and IP3 signaling", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-XTR-156711:r:Polo-like kinase mediated events", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-DME-9013407:r:RHOH GTPase cycle", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-GGA-351451:r:Homologous recombination repair of replication-dependent double-strand breaks", "R-BTA-5635838:r:Activation of SMO", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-111931:r:PKA-mediated phosphorylation of CREB", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DRE-9020958:r:Interleukin-21 signaling", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-163560:r:Triglyceride catabolism", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-MMU-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-8853659:r:RET signaling", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-432395:r:Degradation of TIM", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-SSC-8851805:r:MET activates RAS signaling", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-163615:r:PKA activation", "R-RNO-186763:r:Downstream signal transduction", "R-DME-432501:r:Transcription repression by PER and activation by PDP1", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-9013026:r:RHOB GTPase cycle", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-DME-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-RNO-9020591:r:Interleukin-12 signaling", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SSC-8849470:r:PTK6 Regulates Cell Cycle", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-SSC-8935690:r:Digestion", "R-DDI-202424:r:Downstream TCR signaling", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-CEL-9013407:r:RHOH GTPase cycle", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-8980692:r:RHOA GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5610787:r:Hedgehog 'off' state", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SCE-165158:r:Activation of AKT2", "R-HSA-9702577:r:semaxanib-resistant FLT3 mutants", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-432524:r:Degradation of PER", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-1502540:r:Signaling by Activin", "R-BTA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-1181150:r:Signaling by NODAL", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-GGA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-201451:r:Signaling by BMP", "R-DRE-877312:r:Regulation of IFNG signaling", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-DDI-437239:r:Recycling pathway of L1", "R-DME-111933:r:Calmodulin induced events", "R-RNO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-75153:r:Apoptotic execution phase", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-GGA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DME-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-354192:r:Integrin signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-68881:r:Mitotic Metaphase/Anaphase Transition", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-MMU-5621480:r:Dectin-2 family", "R-SSC-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-GGA-912631:r:Regulation of signaling by CBL", "R-BTA-110056:r:MAPK3 (ERK1) activation", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-8983711:r:OAS antiviral response", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SCE-2465910:r:MASTL Facilitates Mitotic Progression", "R-BTA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-74749:r:Signal attenuation", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-418885:r:DCC mediated attractive signaling", "R-SPO-381070:r:IRE1alpha activates chaperones", "R-GGA-451478:r:ERK activation", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-381070:r:IRE1alpha activates chaperones", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-CEL-201688:r:WNT mediated activation of DVL", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-RNO-422356:r:Regulation of insulin secretion", "R-SPO-2871837:r:FCERI mediated NF-kB activation", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-9634597:r:GPER1 signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-5632684:r:Hedgehog 'on' state", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-XTR-5357905:r:Regulation of TNFR1 signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-191650:r:Regulation of gap junction activity", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5578768:r:Physiological factors", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-216083:r:Integrin cell surface interactions", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-9717264:r:ASP-3026-resistant ALK mutants", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-BTA-445355:r:Smooth Muscle Contraction", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DME-76005:r:Response to elevated platelet cytosolic Ca2+", "R-GGA-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9616222:r:Transcriptional regulation of granulopoiesis", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-SPO-1632852:r:Macroautophagy", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-114516:r:Disinhibition of SNARE formation", "R-SPO-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-198693:r:AKT phosphorylates targets in the nucleus", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DDI-165181:r:Inhibition of TSC complex formation by PKB", "R-XTR-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-201451:r:Signaling by BMP", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-DRE-1059683:r:Interleukin-6 signaling", "R-DME-4086398:r:Ca2+ pathway", "R-MMU-5674499:r:Negative feedback regulation of MAPK pathway", "R-CEL-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-GGA-1227739:r:Caspase-8 and -10 mediated induction of NF-kB", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-CEL-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-DRE-4419969:r:Depolymerization of the Nuclear Lamina", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9652817:r:Signaling by MAPK mutants", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-SSC-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-RNO-9766229:r:Degradation of CDH1", "R-SPO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-RNO-68949:r:Orc1 removal from chromatin", "R-PFA-8963896:r:HDL assembly", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-9968551:r:Regulation of GBP-mediated host defense", "R-RNO-1632852:r:Macroautophagy", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-RNO-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DRE-5621480:r:Dectin-2 family", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-BTA-9634597:r:GPER1 signaling", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-DME-1433559:r:Regulation of KIT signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-RNO-2029481:r:FCGR activation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-CFA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-CFA-432142:r:Platelet sensitization by LDL", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-432620:r:Dephosphorylation of PER", "R-HSA-1433559:r:Regulation of KIT signaling", "R-CEL-112411:r:MAPK1 (ERK2) activation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-418597:r:G alpha (z) signalling events", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-SSC-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-110523:r:TOR signaling pathway", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-PFA-171007:r:p38MAPK events", "R-SSC-1227986:r:Signaling by ERBB2", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-176417:r:Phosphorylation of Emi1", "R-HSA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-198765:r:Signalling to ERK5", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-SPO-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-8983711:r:OAS antiviral response", "R-SSC-1059683:r:Interleukin-6 signaling", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-SPO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-381070:r:IRE1alpha activates chaperones", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-9717326:r:crizotinib-resistant ALK mutants", "R-HSA-74752:r:Signaling by Insulin receptor", "R-BTA-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-SSC-8865999:r:MET activates PTPN11", "R-MMU-525793:r:Myogenesis", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-3000170:r:Syndecan interactions", "R-SPO-198765:r:Signalling to ERK5", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DDI-2028269:r:Signaling by Hippo", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DME-9013420:r:RHOU GTPase cycle", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-CEL-176187:r:Activation of ATR in response to replication stress", "R-DDI-8934903:r:Receptor Mediated Mitophagy", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-GGA-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-DRE-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-CEL-190322:r:FGFR4 ligand binding and activation", "R-SCE-5610787:r:Hedgehog 'off' state", "R-DME-112409:r:RAF-independent MAPK1/3 activation", "R-DME-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-DRE-9013106:r:RHOC GTPase cycle", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DME-69473:r:G2/M DNA damage checkpoint", "R-MMU-8853659:r:RET signaling", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-77387:r:Insulin receptor recycling", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-170968:r:Frs2-mediated activation", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-DME-354192:r:Integrin signaling", "R-DME-110478:r:Insulin signaling pathway", "R-DRE-177929:r:Signaling by EGFR", "R-HSA-9620244:r:Long-term potentiation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-418555:r:G alpha (s) signalling events", "R-DME-418592:r:ADP signalling through P2Y purinoceptor 1", "R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-389356:r:Co-stimulation by CD28", "R-DDI-198323:r:AKT phosphorylates targets in the cytosol", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-SPO-450341:r:Activation of the AP-1 family of transcription factors", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-525793:r:Myogenesis", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-RNO-9648002:r:RAS processing", "R-HSA-171007:r:p38MAPK events", "R-DME-450341:r:Activation of the AP-1 family of transcription factors", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-GGA-210990:r:PECAM1 interactions", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-SCE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-CEL-418594:r:G alpha (i) signalling events", "R-RNO-180292:r:GAB1 signalosome", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-DME-9614399:r:Regulation of localization of FOXO transcription factors", "R-BTA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-9604323:r:Negative regulation of NOTCH4 signaling", "R-PFA-164378:r:PKA activation in glucagon signalling", "R-GGA-9732724:r:IFNG signaling activates MAPKs", "R-DDI-8854214:r:TBC/RABGAPs", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-216217:r:Activation of SMO", "R-RNO-9020558:r:Interleukin-2 signaling", "R-SCE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DME-9020558:r:Interleukin-2 signaling", "R-SCE-450341:r:Activation of the AP-1 family of transcription factors", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-GGA-354192:r:Integrin signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-MMU-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-DME-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-139910:r:Activation of BMF and translocation to mitochondria", "R-DME-209459:r:Imd pathway", "R-CEL-389359:r:CD28 dependent Vav1 pathway", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-74713:r:IRS activation", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-GGA-375165:r:NCAM signaling for neurite out-growth", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-BTA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-BTA-8980692:r:RHOA GTPase cycle", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-GGA-5673000:r:RAF activation", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-191650:r:Regulation of gap junction activity", "R-RNO-69478:r:G2/M DNA replication checkpoint", "R-DME-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-CEL-381042:r:PERK regulates gene expression", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-XTR-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-69416:r:Dimerization of procaspase-8", "R-BTA-5578775:r:Ion homeostasis", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-DME-165181:r:Inhibition of TSC complex formation by PKB", "R-DME-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-PFA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-DME-177929:r:Signaling by EGFR", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-BTA-418457:r:cGMP effects", "R-RNO-74713:r:IRS activation", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-198753:r:ERK/MAPK targets", "R-RNO-111446:r:Activation of BIM and translocation to mitochondria", "R-RNO-68884:r:Mitotic Telophase/Cytokinesis", "R-PFA-9634597:r:GPER1 signaling", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SSC-9020591:r:Interleukin-12 signaling", "R-CEL-8980692:r:RHOA GTPase cycle", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-XTR-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2029481:r:FCGR activation", "R-SPO-202424:r:Downstream TCR signaling", "R-RNO-8983432:r:Interleukin-15 signaling", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-170968:r:Frs2-mediated activation", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9007892:r:Interleukin-38 signaling", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-DME-201681:r:TCF dependent signaling in response to WNT", "R-DRE-198753:r:ERK/MAPK targets", "R-HSA-212436:r:Generic Transcription Pathway", "R-DME-5673000:r:RAF activation", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-74752:r:Signaling by Insulin receptor", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-69231:r:Cyclin D associated events in G1", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-DME-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-416476:r:G alpha (q) signalling events", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9702509:r:FLT3 mutants bind TKIs", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-SCE-1489509:r:DAG and IP3 signaling", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-SPO-432142:r:Platelet sensitization by LDL", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-DME-165159:r:MTOR signalling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9702581:r:crenolanib-resistant FLT3 mutants", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-CEL-1227986:r:Signaling by ERBB2", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-68875:r:Mitotic Prophase", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-DDI-110056:r:MAPK3 (ERK1) activation", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-2028269:r:Signaling by Hippo", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-CFA-201556:r:Signaling by ALK", "R-HSA-9022535:r:Loss of phosphorylation of MECP2 at T308", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DDI-9634597:r:GPER1 signaling", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-68875:r:Mitotic Prophase", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-MMU-1502540:r:Signaling by Activin", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-74713:r:IRS activation", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-DME-5218900:r:CASP8 activity is inhibited", "R-CEL-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-GGA-392517:r:Rap1 signalling", "R-CEL-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-3928664:r:Ephrin signaling", "R-CEL-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-9007892:r:Interleukin-38 signaling", "R-DDI-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-DME-6794361:r:Neurexins and neuroligins", "R-XTR-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-RNO-9020702:r:Interleukin-1 signaling", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-9619229:r:Activation of RAC1 downstream of NMDARs", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8875791:r:MET activates STAT3", "R-DME-69478:r:G2/M DNA replication checkpoint", "R-SPO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-RNO-68911:r:G2 Phase", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-BTA-8853659:r:RET signaling", "R-DDI-8953750:r:Transcriptional Regulation by E2F6", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-DDI-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-DME-5674135:r:MAP2K and MAPK activation", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DRE-418594:r:G alpha (i) signalling events", "R-SSC-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-9632697:r:Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4", "R-HSA-3928664:r:Ephrin signaling", "R-CEL-1912408:r:Pre-NOTCH Transcription and Translation", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-SCE-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-199920:r:CREB phosphorylation", "R-DME-450520:r:HuR (ELAVL1) binds and 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ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Domain"}, "IPR000724": {"description": "IgG-binding B", "go_ids": ["GO:0005618"], "go_terms": ["GO:0005618:cell wall:C"], "name": "IgG-bd_B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000725": {"description": "Olfactory receptor", "go_ids": ["GO:0004984", "GO:0007186", "GO:0016020"], "go_terms": ["GO:0004984:olfactory receptor activity:F", "GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "Olfact_rcpt", "pathway_ids": ["R-HSA-381753", "R-CFA-381753", "R-HSA-9752946", "R-MMU-381753"], "pathways": ["R-HSA-381753:r:Olfactory Signaling Pathway", "R-CFA-381753:r:Olfactory Signaling Pathway", "R-HSA-9752946:r:Expression and translocation of 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into the endoplasmic reticulum membrane", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-181429:r:Serotonin Neurotransmitter 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"R-MMU-5694530", "R-MMU-2122948", "R-RNO-3000157", "R-SSC-1250347", "R-GGA-1227986", "R-RNO-8964038", "R-HSA-2855086", "R-DRE-5673001", "R-HSA-5694530", "R-RNO-350054", "R-MMU-381426", "R-HSA-5083625", "R-BTA-2022870", "R-RNO-5673001", "R-MMU-2022923", "R-RNO-159740", "R-RNO-3000178", "R-RNO-8866427", "R-HSA-212718", "R-GGA-8856828", "R-GGA-212718", "R-HSA-447043", "R-MMU-2168880", "R-RNO-179812", "R-MMU-180292", "R-HSA-210993", "R-HSA-9694614", "R-RNO-2142770", "R-RNO-1566948", "R-MMU-9762292", "R-MMU-198933", "R-MMU-9018679", "R-HSA-8941237", "R-MMU-6798695", "R-RNO-6794361", "R-BTA-159763", "R-CEL-1650814", "R-GGA-179812", "R-GGA-1306955", "R-MMU-114608", "R-DRE-9013423", "R-SSC-1257604", "R-DME-350379", "R-HSA-6809371", "R-HSA-977225", "R-RNO-159782", "R-BTA-3000178", "R-MMU-3000480", "R-GGA-8863795", "R-RNO-9758881", "R-DRE-9013149", "R-MMU-977068", "R-DME-1250347", "R-DME-450728", "R-BTA-2024101", "R-BTA-159740", "R-HSA-2162123", "R-RNO-209968", "R-DME-180292", "R-HSA-8963896", "R-HSA-2894862", "R-HSA-9927432", "R-HSA-1227986", "R-HSA-9937080", "R-RNO-186797", "R-HSA-2160916", "R-CFA-140180", "R-MMU-6806942", "R-MMU-8866376", "R-HSA-8957275", "R-GGA-159763", "R-RNO-182971", "R-HSA-8866376", "R-HSA-2197563", "R-DDI-9753281", "R-HSA-2243919", "R-HSA-9672396", "R-DRE-186797", "R-DDI-1660661", "R-HSA-3560783", "R-HSA-3000178", "R-RNO-1474228", "R-RNO-9025094", "R-HSA-9918485", "R-RNO-9009391", "R-RNO-140875", "R-MMU-210993", "R-HSA-9856532", "R-HSA-3656237", "R-SSC-202733", "R-DDI-114608", "R-GGA-8866376", "R-RNO-8863795", "R-SSC-9009391", "R-BTA-8957275", "R-HSA-5083630", "R-CEL-2129379", "R-MMU-5632681", "R-GGA-9009391", "R-HSA-3359462", "R-HSA-166663", "R-HSA-446107", "R-MMU-1566948", "R-MMU-5673001", "R-DME-390023", "R-RNO-212718", "R-DDI-1369062", "R-HSA-182971", "R-CFA-159782", "R-HSA-9018679", "R-HSA-5637810", "R-DRE-5362798", "R-HSA-9696264", "R-HSA-2022090", "R-SSC-212718", "R-RNO-9696264", "R-HSA-9793380", "R-DME-9013700", "R-MMU-2024101", "R-HSA-2644606", "R-DME-182971", "R-DME-373752", "R-HSA-8857538", "R-DME-1358803", "R-CFA-202733", "R-HSA-3000497", "R-DME-5673001", "R-HSA-3000480", "R-HSA-977068", "R-MMU-2122947", "R-XTR-8941856", "R-HSA-373760", "R-HSA-9013423", "R-CEL-9010553", "R-HSA-9013700", "R-MMU-1250347", "R-HSA-3359463", "R-HSA-1250196", "R-HSA-5340588", "R-HSA-2022928", "R-MMU-167060", "R-GGA-1250196", "R-BTA-8856828", "R-RNO-446107", "R-MMU-977606", "R-RNO-1250342", "R-HSA-5339717", "R-HSA-376176", "R-RNO-1227986", "R-CEL-2160916", "R-HSA-9758890", "R-HSA-350054", "R-DME-1474228", "R-GGA-1250347", "R-MMU-212718", "R-MMU-1650814", "R-RNO-180336", "R-GGA-1236394", "R-HSA-8964038", "R-GGA-1250342", "R-HSA-9022702", "R-MMU-6785631", "R-MMU-159740", "R-SSC-2179392", "R-GGA-159782", "R-RNO-8866376", "R-BTA-2173789", "R-HSA-9927418", "R-MMU-2243919", "R-HSA-1650814", "R-MMU-2214320", "R-SSC-6811558", "R-DME-2214320", "R-HSA-2142845", "R-MMU-3000178", "R-RNO-202733", "R-HSA-177929", "R-HSA-5621480", "R-HSA-75205", "R-HSA-381426", "R-HSA-2173789", "R-GGA-180292", "R-HSA-9629569", "R-CFA-159763", "R-HSA-2024101", "R-DME-1227986", "R-HSA-9665686", "R-CEL-2024101", "R-RNO-198933", "R-HSA-8847993", "R-MMU-140837", "R-RNO-446203", "R-RNO-9013507", "R-MMU-2160916", "R-MMU-9604323", "R-MMU-2142770", "R-HSA-9013149", "R-MMU-9913351", "R-MMU-8866427", "R-HSA-3656243", "R-HSA-4420332", "R-HSA-9911233", "R-HSA-167060", "R-HSA-198933", "R-CEL-6809371", "R-RNO-9018679", "R-MMU-2022870", "R-DME-8957275", "R-HSA-2122948", "R-HSA-3000157", "R-DRE-2243919", "R-RNO-9017802", "R-HSA-9619665", "R-DME-350368", "R-RNO-2129379", "R-BTA-202733", "R-HSA-1912408", "R-DME-6811558", "R-HSA-9017802", "R-RNO-8957275", "R-HSA-1236382", "R-HSA-8866910", "R-BTA-381426", "R-HSA-9027604", "R-DME-8856828", "R-GGA-180336", "R-HSA-9833110", "R-MMU-1358803", "R-CFA-381426", "R-RNO-1963640", "R-MMU-6794361", "R-MMU-8963889", "R-RNO-204005", "R-HSA-1236394", "R-SSC-177929", "R-HSA-9830674", "R-MMU-8963896", "R-HSA-9831926", "R-HSA-2892247", "R-MMU-1971475", "R-RNO-2160916", "R-MMU-8857538", "R-HSA-913709", "R-HSA-9696273"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-1566948:r:Elastic fibre formation", "R-MMU-166662:r:Lectin pathway of complement activation", "R-SSC-1236394:r:Signaling by ERBB4", "R-DDI-189451:r:Heme biosynthesis", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-HSA-9018677:r:Biosynthesis of DHA-derived SPMs", "R-RNO-8964046:r:VLDL clearance", "R-BTA-977606:r:Regulation of Complement cascade", "R-GGA-9018679:r:Biosynthesis of EPA-derived SPMs", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-SSC-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-GGA-8857538:r:PTK6 promotes HIF1A stabilization", "R-DRE-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-DDI-2129379:r:Molecules associated with elastic fibres", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-9018677:r:Biosynthesis of DHA-derived SPMs", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-GGA-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-9824272:r:Somitogenesis", "R-BTA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-GGA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-114608:r:Platelet degranulation", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-SSC-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-3000178:r:ECM proteoglycans", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-166662:r:Lectin pathway of complement activation", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-8964046:r:VLDL clearance", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-2024096:r:HS-GAG degradation", "R-MMU-432142:r:Platelet sensitization by LDL", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9673240:r:Defective gamma-carboxylation of F9", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-BTA-166665:r:Terminal pathway of complement", "R-CEL-216083:r:Integrin cell surface interactions", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-MMU-2142845:r:Hyaluronan metabolism", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-XTR-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9672383:r:Defective factor IX causes thrombophilia", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-MMU-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-RNO-166662:r:Lectin pathway of complement activation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-1566948:r:Elastic fibre formation", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8964046:r:VLDL clearance", "R-RNO-114608:r:Platelet degranulation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-RNO-977068:r:Termination of O-glycan biosynthesis", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-2024096:r:HS-GAG degradation", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9018677:r:Biosynthesis of DHA-derived SPMs", "R-HSA-2214320:r:Anchoring fibril formation", "R-SSC-179812:r:GRB2 events in EGFR signaling", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-DDI-1566977:r:Fibronectin matrix formation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-1963640:r:GRB2 events in ERBB2 signaling", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-RNO-1236394:r:Signaling by ERBB4", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-CEL-376176:r:Signaling by ROBO receptors", "R-SSC-182971:r:EGFR downregulation", "R-MMU-5173105:r:O-linked glycosylation", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-DME-1912420:r:Pre-NOTCH Processing in Golgi", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-GGA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-390150:r:DS ligand bound to FT receptor", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-DDI-1474228:r:Degradation of the extracellular matrix", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DME-9013149:r:RAC1 GTPase cycle", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-BTA-1566948:r:Elastic fibre formation", "R-CEL-2214320:r:Anchoring fibril formation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-114608:r:Platelet degranulation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-DDI-8964058:r:HDL remodeling", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-DME-6809371:r:Formation of the cornified envelope", "R-HSA-5173105:r:O-linked glycosylation", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-376176:r:Signaling by ROBO receptors", "R-SSC-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-140180:r:COX reactions", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-SSC-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-9758890:r:Transport of RCbl within the body", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-MMU-5682910:r:LGI-ADAM interactions", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-SSC-1227986:r:Signaling by ERBB2", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-1181150:r:Signaling by NODAL", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-140180:r:COX reactions", "R-SSC-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-1442490:r:Collagen degradation", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-GGA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DRE-6794361:r:Neurexins and neuroligins", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-8964026:r:Chylomicron clearance", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-GGA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-MMU-140180:r:COX reactions", "R-HSA-5682910:r:LGI-ADAM interactions", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-HSA-9673218:r:Defective F9 secretion", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-CFA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-MMU-182971:r:EGFR downregulation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-432142:r:Platelet sensitization by LDL", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-8964026:r:Chylomicron clearance", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-RNO-9758890:r:Transport of RCbl within the body", "R-SSC-180336:r:SHC1 events in EGFR signaling", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-SSC-8857538:r:PTK6 promotes HIF1A stabilization", "R-RNO-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DME-1236394:r:Signaling by ERBB4", "R-HSA-9830364:r:Formation of the nephric duct", "R-DDI-9793528:r:Ciprofloxacin ADME", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-6798695:r:Neutrophil degranulation", "R-DRE-210993:r:Tie2 Signaling", "R-HSA-9673221:r:Defective F9 activation", "R-GGA-9018677:r:Biosynthesis of DHA-derived SPMs", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-9620244:r:Long-term potentiation", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-HSA-8964011:r:HDL clearance", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-BTA-114608:r:Platelet degranulation", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-MMU-8941237:r:Invadopodia formation", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-RNO-180292:r:GAB1 signalosome", "R-CEL-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-RNO-167060:r:NGF processing", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-GGA-182971:r:EGFR downregulation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9673202:r:Defective F9 variant does not activate FX", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-GGA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-975634:r:Retinoid metabolism and transport", "R-HSA-209968:r:Thyroxine biosynthesis", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-5632681:r:Ligand-receptor interactions", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-GGA-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-GGA-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-MMU-1236394:r:Signaling by ERBB4", "R-DRE-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-CEL-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-8964011:r:HDL clearance", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-CFA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-209968:r:Thyroxine biosynthesis", "R-DDI-189483:r:Heme degradation", "R-HSA-9762292:r:Regulation of CDH11 function", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-CFA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-8964038:r:LDL clearance", "R-RNO-177929:r:Signaling by EGFR", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-DME-376176:r:Signaling by ROBO receptors", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-RNO-8941237:r:Invadopodia formation", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-GGA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-MMU-3000157:r:Laminin interactions", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-3000170:r:Syndecan interactions", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-8964026:r:Chylomicron clearance", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DME-177929:r:Signaling by EGFR", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-SSC-75205:r:Dissolution of Fibrin Clot", "R-DME-2243919:r:Crosslinking of collagen fibrils", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-GGA-177929:r:Signaling by EGFR", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-HSA-428540:r:Activation of RAC1", "R-SSC-180292:r:GAB1 signalosome", "R-BTA-216083:r:Integrin cell surface interactions", "R-SSC-186797:r:Signaling by PDGF", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-SSC-1963642:r:PI3K events in ERBB2 signaling", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-BTA-8964026:r:Chylomicron clearance", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5694530:r:Cargo concentration in the ER", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-3000157:r:Laminin interactions", "R-SSC-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1227986:r:Signaling by ERBB2", "R-RNO-8964038:r:LDL clearance", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-GGA-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-447043:r:Neurofascin interactions", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-9694614:r:Attachment and Entry", "R-RNO-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-RNO-1566948:r:Elastic fibre formation", "R-MMU-9762292:r:Regulation of CDH11 function", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-9018679:r:Biosynthesis of EPA-derived SPMs", "R-HSA-8941237:r:Invadopodia formation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6794361:r:Neurexins and neuroligins", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-GGA-179812:r:GRB2 events in EGFR signaling", "R-GGA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-114608:r:Platelet degranulation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-BTA-3000178:r:ECM proteoglycans", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-DME-450728:r:Inhibition of actin polymerization", "R-BTA-2024101:r:CS/DS degradation", "R-BTA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-RNO-209968:r:Thyroxine biosynthesis", "R-DME-180292:r:GAB1 signalosome", "R-HSA-8963896:r:HDL assembly", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-2160916:r:Hyaluronan degradation", "R-CFA-140180:r:COX reactions", "R-MMU-6806942:r:MET Receptor Activation", "R-MMU-8866376:r:Reelin signalling pathway", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-GGA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-RNO-182971:r:EGFR downregulation", "R-HSA-8866376:r:Reelin signalling pathway", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-DDI-9753281:r:Paracetamol ADME", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-DRE-186797:r:Signaling by PDGF", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-RNO-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-DDI-114608:r:Platelet degranulation", "R-GGA-8866376:r:Reelin 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"R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-3359463:r:Defective CUBN causes MGA1", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-MMU-167060:r:NGF processing", "R-GGA-1250196:r:SHC1 events in ERBB2 signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-HSA-376176:r:Signaling by ROBO receptors", "R-RNO-1227986:r:Signaling by ERBB2", "R-CEL-2160916:r:Hyaluronan degradation", "R-HSA-9758890:r:Transport of RCbl within the body", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-GGA-1236394:r:Signaling by ERBB4", "R-HSA-8964038:r:LDL clearance", "R-GGA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-SSC-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-8866376:r:Reelin signalling pathway", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2214320:r:Anchoring fibril formation", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-2214320:r:Anchoring fibril formation", "R-HSA-2142845:r:Hyaluronan metabolism", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-GGA-180292:r:GAB1 signalosome", "R-HSA-9629569:r:Protein hydroxylation", "R-CFA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-2024101:r:CS/DS degradation", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-CEL-2024101:r:CS/DS degradation", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-446203:r:Asparagine N-linked glycosylation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-9911233:r:Expression of NOTCH2NL genes", "R-HSA-167060:r:NGF processing", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-6809371:r:Formation of the cornified envelope", "R-RNO-9018679:r:Biosynthesis of EPA-derived SPMs", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-3000157:r:Laminin interactions", "R-DRE-2243919:r:Crosslinking of collagen fibrils", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-GGA-180336:r:SHC1 events in EGFR signaling", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-6794361:r:Neurexins and neuroligins", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-1236394:r:Signaling by ERBB4", "R-SSC-177929:r:Signaling by EGFR", "R-HSA-9830674:r:Formation of the ureteric bud", "R-MMU-8963896:r:HDL assembly", "R-HSA-9831926:r:Nephron development", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-2160916:r:Hyaluronan degradation", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR000743": {"description": "Glycoside hydrolase, family 28", "go_ids": ["GO:0004650", "GO:0005975"], "go_terms": ["GO:0004650:polygalacturonase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000744": {"description": "NSF attachment protein", "go_ids": ["GO:0006886"], "go_terms": ["GO:0006886:intracellular protein transport:P"], "name": "NSF_attach", "pathway_ids": ["R-SPO-6807878", "R-MMU-204005", "R-HSA-6811438", "R-MMU-6811438", "R-MMU-432722", "R-SCE-204005", "R-MMU-6807878", "R-DDI-6811434", "R-HSA-6811440", "R-DME-6811438", "R-BTA-6807878", "R-HSA-6811434", "R-DDI-6811440", "R-BTA-204005", "R-DME-6807878", "R-HSA-432722", "R-RNO-432722", "R-MMU-6811434", "R-SCE-6811440", "R-RNO-6811440", "R-DME-6811440", "R-SCE-6807878", "R-RNO-6811434", "R-SCE-6811434", "R-DDI-204005", "R-RNO-6807878", "R-RNO-6811438", "R-HSA-6807878", "R-SPO-204005", "R-BTA-6811440", "R-SPO-6811440", "R-RNO-204005", "R-MMU-6811440", "R-DDI-6811438", "R-HSA-204005", "R-DME-6811434", "R-SPO-6811438", "R-DDI-6807878", "R-SPO-6811434", "R-SCE-6811438", "R-BTA-6811438", "R-BTA-6811434", "R-DME-204005"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-6811438:r:Intra-Golgi traffic", 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transport at the Trans-Golgi-Network", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", 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family"], "type": "Domain"}, "IPR000748": {"description": "Pseudouridine synthase, RsuA/RluB/E/F", "go_ids": ["GO:0001522", "GO:0003723", "GO:0009451", "GO:0016866"], "go_terms": ["GO:0001522:pseudouridine synthesis:P", "GO:0003723:RNA binding:F", "GO:0009451:RNA modification:P", "GO:0016866:intramolecular transferase activity:F"], "name": "PsdUridine_synth_RsuA/RluB/E/F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000749": {"description": "ATP:guanido phosphotransferase", "go_ids": ["GO:0016775", "GO:0046314"], "go_terms": ["GO:0016775:phosphotransferase activity, nitrogenous group as acceptor:F", "GO:0046314:phosphocreatine biosynthetic process:P"], "name": "ATP-guanido_PTrfase", "pathway_ids": ["R-CFA-9696264", "R-MMU-71288", "R-HSA-71288", "R-BTA-9696264", "R-RNO-71288", "R-SSC-71288", "R-RNO-9696264", "R-CFA-71288", "R-MMU-9696264", "R-BTA-71288", "R-GGA-71288", "R-HSA-9696264", "R-GGA-9696264"], "pathways": ["R-CFA-9696264:r:RND3 GTPase cycle", 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"R-MMU-156711", "R-HSA-156711", "R-HSA-69601", "R-BTA-6804115", "R-RNO-69273", "R-CEL-5689880", "R-CEL-69601", "R-CEL-156711", "R-SPO-69601", "R-DME-75035", "R-SCE-156711", "R-HSA-69202", "R-DME-5689880", "R-DME-69656"], "pathways": ["R-SCE-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-156711:r:Polo-like kinase mediated events", "R-CEL-176187:r:Activation of ATR in response to replication stress", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-5689880:r:Ub-specific processing proteases", "R-SSC-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SSC-176187:r:Activation of ATR in response to replication stress", "R-RNO-176187:r:Activation of ATR 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proliferation", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-SSC-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-69202:r:Cyclin E associated events during G1/S transition", "R-SCE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DME-156711:r:Polo-like kinase mediated events", "R-RNO-5689880:r:Ub-specific processing proteases", "R-SPO-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SPO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DDI-5625740:r:RHO GTPases activate PKNs", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-69202:r:Cyclin E associated events during G1/S transition", "R-SPO-156711:r:Polo-like kinase mediated events", "R-CEL-69202:r:Cyclin E associated events during G1/S transition", "R-SCE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DDI-176187:r:Activation of ATR in response to replication stress", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DDI-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-CEL-5625740:r:RHO GTPases activate PKNs", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-BTA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DDI-5689880:r:Ub-specific processing proteases", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-SSC-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-156711:r:Polo-like kinase mediated events", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-5689880:r:Ub-specific processing proteases", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-156711:r:Polo-like kinase mediated events", "R-SPO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-SCE-156711:r:Polo-like kinase mediated events", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry"], "type": "Family"}, "IPR000752": {"description": "Flavivirus non-structural protein NS2A", "go_ids": ["GO:0003725"], "go_terms": ["GO:0003725:double-stranded RNA binding:F"], "name": "Flavi_NS2A", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", 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"R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000755": {"description": "D-alanyl-D-alanine dipeptidase", "go_ids": ["GO:0006508", "GO:0008237", "GO:0016805"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008237:metallopeptidase activity:F", "GO:0016805:dipeptidase activity:F"], "name": "A_A_dipeptidase", "pathway_ids": ["PWY-6454", "PWY-6455"], "pathways": ["PWY-6454:t:vancomycin resistance I", "PWY-6455:t:vancomycin resistance II"], "type": "Family"}, "IPR000756": {"description": "Diacylglycerol kinase, accessory domain", "go_ids": ["GO:0004143", "GO:0007200"], "go_terms": ["GO:0004143:ATP-dependent diacylglycerol kinase activity:F", "GO:0007200:phospholipase C-activating G protein-coupled receptor signaling pathway:P"], "name": "Diacylglycerol_kin_accessory", "pathway_ids": ["PWY-7039", "PWY-7817", "R-MMU-114508", "R-SSC-114508", "R-BTA-114508", "R-HSA-114508", "R-CEL-114508", "R-DDI-114508", "R-RNO-114508", "R-DME-114508"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-SSC-114508:r:Effects of PIP2 hydrolysis", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-DME-114508:r:Effects of PIP2 hydrolysis"], "type": "Domain"}, "IPR000757": {"description": "Beta-glucanase-like, N-terminal domain", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Beta-glucanase-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000758": {"description": "Virulence-related outer membrane protein", "go_ids": ["GO:0044384"], "go_terms": ["GO:0044384:host outer membrane:C"], "name": "Enterovir_OMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000760": {"description": "Inositol monophosphatase-like", "go_ids": [], "go_terms": [], "name": "Inositol_monophosphatase-like", "pathway_ids": ["R-MTU-936635", "R-DDI-1855183", "R-DME-156584", "R-DDI-156584", "R-DRE-156584", "R-BTA-1855183", "R-CEL-1855183", "R-BTA-156584", "R-MMU-156584", "R-SCE-1855183", "R-SSC-156584", "R-RNO-1855183", "R-HSA-1855183", "R-MMU-1855183", "R-HSA-156584", "R-RNO-156584", "R-MTU-879299", "R-XTR-156584"], "pathways": ["R-MTU-936635:r:Sulfate assimilation", "R-DDI-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-DME-156584:r:Cytosolic sulfonation of small molecules", "R-DDI-156584:r:Cytosolic sulfonation of small molecules", "R-DRE-156584:r:Cytosolic sulfonation of small molecules", "R-BTA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-CEL-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-BTA-156584:r:Cytosolic sulfonation of small molecules", "R-MMU-156584:r:Cytosolic sulfonation of small molecules", "R-SCE-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-SSC-156584:r:Cytosolic sulfonation of small molecules", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-156584:r:Cytosolic sulfonation of small molecules", "R-RNO-156584:r:Cytosolic sulfonation of small molecules", "R-MTU-879299:r:Mycothiol biosynthesis", "R-XTR-156584:r:Cytosolic sulfonation of small molecules"], "type": "Family"}, "IPR000762": {"description": "Midkine heparin-binding growth factor", "go_ids": ["GO:0008083"], "go_terms": ["GO:0008083:growth factor activity:F"], "name": "Midkine_heparin-bd_GF", "pathway_ids": ["R-RNO-201556", "R-MMU-201556", "R-XTR-2979096", "R-HSA-2979096", "R-BTA-201556", "R-SSC-9851151", "R-GGA-9851151", "R-HSA-201556", "R-RNO-9851151", "R-XTR-201556", "R-GGA-201556", "R-MMU-9851151", "R-SSC-201556", "R-BTA-9851151", "R-XTR-9851151", "R-HSA-9851151"], "pathways": ["R-RNO-201556:r:Signaling by ALK", "R-MMU-201556:r:Signaling by ALK", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-BTA-201556:r:Signaling by ALK", "R-SSC-9851151:r:MDK and PTN in ALK signaling", "R-GGA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-201556:r:Signaling by ALK", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-XTR-201556:r:Signaling by ALK", "R-GGA-201556:r:Signaling by ALK", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-SSC-201556:r:Signaling by ALK", "R-BTA-9851151:r:MDK and PTN in ALK signaling", "R-XTR-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9851151:r:MDK and PTN in ALK signaling"], "type": "Family"}, "IPR000763": {"description": "Catalase-peroxidase haem", "go_ids": ["GO:0004096", "GO:0004601", "GO:0006979", "GO:0020037"], "go_terms": ["GO:0004096:catalase activity:F", "GO:0004601:peroxidase activity:F", "GO:0006979:response to oxidative stress:P", "GO:0020037:heme binding:F"], "name": "Catalase_peroxidase", "pathway_ids": ["PWY-5506", "R-HSA-1222387"], "pathways": ["PWY-5506:t:methanol oxidation to formaldehyde IV", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Family"}, "IPR000764": {"description": "Uridine kinase-like", "go_ids": [], "go_terms": [], "name": "Uridine_kinase-like", "pathway_ids": ["PWY-7193", "R-XTR-73614", "R-CEL-73614", "R-DRE-73614", "R-HSA-73614", "R-SPO-73614", "R-RNO-73614", "R-MMU-73614", "R-SCE-73614", "R-DDI-196807", "R-DME-73614", "R-DDI-73614"], "pathways": ["PWY-7193:t:pyrimidine ribonucleosides salvage I", "R-XTR-73614:r:Pyrimidine salvage", "R-CEL-73614:r:Pyrimidine salvage", "R-DRE-73614:r:Pyrimidine salvage", "R-HSA-73614:r:Pyrimidine salvage", "R-SPO-73614:r:Pyrimidine salvage", "R-RNO-73614:r:Pyrimidine salvage", "R-MMU-73614:r:Pyrimidine salvage", "R-SCE-73614:r:Pyrimidine salvage", "R-DDI-196807:r:Nicotinate metabolism", "R-DME-73614:r:Pyrimidine salvage", "R-DDI-73614:r:Pyrimidine salvage"], "type": "Family"}, "IPR000766": {"description": "Galactose-1-phosphate uridyl transferase, class II", "go_ids": ["GO:0005737", "GO:0006012", "GO:0008108"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006012:galactose metabolic process:P", "GO:0008108:UDP-glucose:hexose-1-phosphate 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"R-RNO-1236978", "R-HSA-190372", "R-BTA-913709", "R-HSA-6811436", "R-HSA-9637628", "R-HSA-5083636", "R-DME-6811436", "R-CEL-6811436", "R-HSA-1236978", "R-BTA-1482839", "R-BTA-1482925", "R-MMU-190372", "R-MMU-1482839", "R-MMU-6811436", "R-HSA-1482801", "R-RNO-6811436", "R-MMU-1483166", "R-BTA-6811436", "R-MMU-1482922", "R-HSA-1482839", "R-CEL-913709", "R-XTR-913709", "R-BTA-1482922", "R-HSA-9683673", "R-MMU-1236978", "R-MMU-1482801", "R-DME-913709", "R-HSA-913709", "R-HSA-1482788"], "pathways": ["R-HSA-9694719:r:Maturation of protein 3a", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-BTA-1483166:r:Synthesis of 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"PWY-7954:t:tabtoxinine-beta-lactam biosynthesis"], "type": "Family"}, "IPR000788": {"description": "Ribonucleotide reductase large subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "RNR_lg_C", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210", "R-HSA-5213460", "R-HSA-9610379", "R-DRE-499943", "R-DME-499943", "R-CEL-499943", "R-HSA-9609690", "R-HSA-9686347", "R-HSA-499943", "R-MMU-499943"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-9610379:r:HCMV Late Events", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Domain"}, "IPR000789": {"description": "Cyclin-dependent kinase, regulatory subunit", "go_ids": ["GO:0016538"], "go_terms": ["GO:0016538:cyclin-dependent protein serine/threonine kinase regulator activity:F"], "name": "Cyclin-dep_kinase_reg-sub", "pathway_ids": ["R-BTA-69231", "R-HSA-187577", "R-MMU-187577", "R-DME-187577", "R-BTA-187577", "R-DDI-69231", "R-DME-69231", "R-HSA-69231", 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"R-HSA-3371511:r:HSF1 activation", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-8876725:r:Protein methylation", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-382556:r:ABC-family proteins mediated transport", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-381042:r:PERK regulates gene expression", "R-MMU-72649:r:Translation initiation complex formation", "R-SPO-156902:r:Peptide chain elongation", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-9840373:r:Cellular response to mitochondrial stress", "R-DDI-156902:r:Peptide chain elongation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DRE-5419276:r:Mitochondrial translation termination", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-156842:r:Eukaryotic Translation Elongation", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-CEL-8876725:r:Protein methylation", "R-SPO-8876725:r:Protein methylation", "R-DME-3371511:r:HSF1 activation", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-MMU-156902:r:Peptide chain elongation", "R-MMU-8876725:r:Protein methylation", "R-DRE-72649:r:Translation initiation complex formation", "R-SPO-3371511:r:HSF1 activation", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-8876725:r:Protein methylation", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-8876725:r:Protein methylation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-3371511:r:HSF1 activation", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-156842:r:Eukaryotic Translation Elongation", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR000796": {"description": "Aspartate/other aminotransferase", "go_ids": ["GO:0006520", "GO:0008483"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0008483:transaminase activity:F"], "name": "Asp_trans", "pathway_ids": ["PWY-7383", "PWY-6638", "PWY-7115", "PWY-6643", "PWY-7117", "PWY-6642", "R-DDI-8964539", "R-HSA-9856872", "R-GGA-8963693", "R-HSA-1614558", "R-HSA-1237112", "R-DDI-9856872", "R-RNO-8964539", "R-SSC-389661", "R-MMU-389661", "R-BTA-8963693", "R-SSC-8964539", "R-CEL-8963693", "R-SPO-9856872", "R-BTA-9856872", "R-SCE-8963693", "R-SCE-389661", "R-BTA-8964539", "R-SPO-8963693", "R-MMU-8964539", "R-RNO-8963693", "R-HSA-8963693", "R-DDI-389661", "R-RNO-389661", "R-GGA-352875", "R-HSA-389661", "R-CEL-9856872", "R-SCE-9856872", "R-GGA-9856872", "R-BTA-389661", "R-HSA-8964539", "R-SPO-8964539", "R-SSC-8963693", "R-SSC-9856872", "R-SPO-389661", "R-MMU-8963693", "R-MMU-9856872", "R-SCE-8964539", "R-RNO-9856872", "R-DDI-8963693", "R-GGA-372568"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-6638:t:sulfolactate degradation III", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-6643:t:coenzyme M biosynthesis II", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-6642:t:(R)-cysteate degradation", "R-DDI-8964539:r:Glutamate and glutamine metabolism", "R-HSA-9856872:r:Malate-aspartate shuttle", "R-GGA-8963693:r:Aspartate and asparagine metabolism", "R-HSA-1614558:r:Degradation of cysteine and homocysteine", "R-HSA-1237112:r:Methionine salvage pathway", "R-DDI-9856872:r:Malate-aspartate shuttle", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-SSC-389661:r:Glyoxylate metabolism and glycine degradation", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-BTA-8963693:r:Aspartate and asparagine metabolism", "R-SSC-8964539:r:Glutamate and glutamine metabolism", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-SPO-9856872:r:Malate-aspartate shuttle", "R-BTA-9856872:r:Malate-aspartate shuttle", "R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-SCE-389661:r:Glyoxylate metabolism and glycine degradation", "R-BTA-8964539:r:Glutamate and glutamine metabolism", "R-SPO-8963693:r:Aspartate and asparagine metabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-DDI-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-389661:r:Glyoxylate metabolism and glycine degradation", "R-GGA-352875:r:Gluconeogenesis", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-SCE-9856872:r:Malate-aspartate shuttle", "R-GGA-9856872:r:Malate-aspartate shuttle", "R-BTA-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-SPO-8964539:r:Glutamate and glutamine metabolism", "R-SSC-8963693:r:Aspartate and asparagine metabolism", "R-SSC-9856872:r:Malate-aspartate shuttle", "R-SPO-389661:r:Glyoxylate metabolism and glycine degradation", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-DDI-8963693:r:Aspartate and asparagine metabolism", "R-GGA-372568:r:Amino acid metabolism"], "type": "Family"}, "IPR000797": {"description": "Bunyavirus non-structural protein NS-s", "go_ids": ["GO:0016032"], "go_terms": ["GO:0016032:viral process:P"], "name": "Bunya_NSs", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000800": {"description": "Notch domain", "go_ids": [], "go_terms": [], "name": "Notch_dom", "pathway_ids": ["R-XTR-2979096", "R-HSA-8941856", "R-HSA-9604323", "R-HSA-2122948", "R-RNO-9017802", "R-MMU-2122947", "R-XTR-8941856", "R-MMU-2122948", "R-HSA-9818749", "R-XTR-2122948", "R-HSA-9824272", "R-XTR-2197563", "R-XTR-1912420", "R-HSA-1912408", 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{"description": "Esterase-like", "go_ids": [], "go_terms": [], "name": "Esterase-like", "pathway_ids": ["R-RNO-156590", "R-MMU-156590", "R-HSA-156590", "R-SSC-156590", "R-BTA-156590", "R-HSA-9638334", "R-SCE-156590"], "pathways": ["R-RNO-156590:r:Glutathione conjugation", "R-MMU-156590:r:Glutathione conjugation", "R-HSA-156590:r:Glutathione conjugation", "R-SSC-156590:r:Glutathione conjugation", "R-BTA-156590:r:Glutathione conjugation", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-SCE-156590:r:Glutathione conjugation"], "type": "Family"}, "IPR000802": {"description": "Arsenical pump membrane protein, ArsB", "go_ids": ["GO:0015105", "GO:0016020", "GO:0015700"], "go_terms": ["GO:0015105:arsenite transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0015700:arsenite transport:P"], "name": "Arsenical_pump_ArsB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000805": {"description": "Glycoside hydrolase family 26", "go_ids": ["GO:0006080", "GO:0016985"], "go_terms": ["GO:0006080:substituted mannan metabolic process:P", "GO:0016985:mannan endo-1,4-beta-mannosidase activity:F"], "name": "Glyco_hydro_26", "pathway_ids": ["PWY-7456"], "pathways": ["PWY-7456:t:beta-(1,4)-mannan degradation"], "type": "Family"}, "IPR000807": {"description": "Imidazoleglycerol-phosphate dehydratase", "go_ids": ["GO:0000105", "GO:0004424"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0004424:imidazoleglycerol-phosphate dehydratase activity:F"], "name": "ImidazoleglycerolP_deHydtase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000810": {"description": "Cannabinoid receptor type 1", "go_ids": ["GO:0004949", "GO:0007186", "GO:0016020"], "go_terms": ["GO:0004949:cannabinoid receptor activity:F", "GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "Canbinoid_rcpt_1", "pathway_ids": ["R-HSA-418594", "R-RNO-373076", "R-MMU-418594", "R-MMU-373076", "R-RNO-418594", 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And Promoter Opening", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Family"}, "IPR000814": {"description": "TATA-box binding protein", "go_ids": ["GO:0006352", "GO:0003677"], "go_terms": ["GO:0006352:DNA-templated transcription initiation:P", "GO:0003677:DNA binding:F"], "name": "TBP", "pathway_ids": ["R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-DME-76061", "R-MMU-75953", "R-SCE-75953", "R-DRE-73779", "R-DME-76042", "R-HSA-427413", "R-SPO-6807505", "R-DDI-73776", "R-MMU-6804756", "R-MMU-76066", "R-DRE-75953", "R-DRE-6807505", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-HSA-427359", "R-DDI-674695", "R-HSA-75953", "R-HSA-76061", "R-MMU-76061", "R-CEL-75953", "R-DME-75953", "R-HSA-749476", "R-MMU-73779", "R-CEL-73776", "R-DRE-76061", "R-HSA-9018519", "R-MMU-76042", "R-DRE-9018519", "R-SPO-75953", "R-SCE-76061", "R-DRE-6804756", "R-MMU-5250924", "R-CEL-6807505", "R-DME-674695", "R-DDI-73779", "R-SPO-9018519", "R-SPO-76066", "R-DME-9018519", "R-DRE-76071", "R-MMU-674695", "R-MMU-6807505", "R-DRE-5250924", "R-SCE-76042", "R-DME-6804756", "R-DDI-6807505", "R-HSA-167161", "R-DME-6807505", "R-MMU-9018519", "R-CEL-674695", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-MMU-73772", "R-SPO-73776", "R-SCE-73776", "R-SCE-76066", "R-DDI-76066", "R-MMU-73762", "R-HSA-76066", "R-SPO-76061", "R-DME-73779", "R-CEL-73772", "R-HSA-167162", "R-DRE-73863", "R-DME-73776", "R-DDI-76061", "R-DDI-73772", "R-DDI-9018519", "R-MMU-73776", "R-DDI-76042", "R-HSA-167172", "R-SCE-73779", "R-HSA-76071", "R-DRE-76042", "R-DRE-73772", "R-MMU-73863", "R-MMU-76071", "R-DRE-73776", "R-HSA-73762", "R-SCE-9018519", "R-HSA-9754189", "R-DRE-76066", "R-HSA-73863", "R-DME-76066", "R-SPO-73772", "R-DRE-674695", "R-CEL-9018519", "R-HSA-5250924", "R-HSA-76042", "R-HSA-674695", "R-DDI-75953", "R-SCE-73772", "R-DME-73772", "R-CEL-76042", "R-HSA-73779"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-76042:r:RNA Polymerase II Transcription 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Initiation", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-DRE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-DME-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR000816": {"description": "Peptidase C15, pyroglutamyl peptidase I", "go_ids": ["GO:0006508", "GO:0016920", "GO:0005829"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0016920:pyroglutamyl-peptidase activity:F", "GO:0005829:cytosol:C"], "name": "Peptidase_C15", "pathway_ids": ["PWY-7942"], "pathways": ["PWY-7942:t:5-oxo-L-proline metabolism"], "type": "Family"}, "IPR000817": {"description": "Prion protein", "go_ids": ["GO:0016020", "GO:0051260"], "go_terms": ["GO:0016020:membrane:C", "GO:0051260:protein homooligomerization:P"], "name": "Prion", "pathway_ids": ["R-MMU-9609523", "R-HSA-9609523", "R-RNO-9609523", "R-GGA-163125", "R-HSA-419037", "R-GGA-9609523"], "pathways": ["R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-419037:r:NCAM1 interactions", "R-GGA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Family"}, "IPR000818": {"description": "TEA/ATTS domain", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "TEA/ATTS_dom", "pathway_ids": ["R-HSA-2032785", "R-HSA-9819196", "R-HSA-9909649", "R-CEL-2032785", "R-HSA-8951671", "R-DME-2032785", "R-MMU-8951671", "R-DME-390193", "R-HSA-9796292", "R-HSA-9619665", "R-MMU-2032785", "R-CEL-8951671", "R-DME-8951671"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-CEL-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-390193:r:Transcriptional activation by YKI", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-CEL-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-8951671:r:RUNX3 regulates YAP1-mediated transcription"], "type": "Domain"}, "IPR000819": {"description": "Peptidase M17, leucyl aminopeptidase, C-terminal", "go_ids": ["GO:0006508", "GO:0046872"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0046872:metal ion binding:F"], "name": "Peptidase_M17_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000821": {"description": "Alanine racemase", "go_ids": ["GO:0008784", "GO:0030632"], "go_terms": ["GO:0008784:alanine racemase activity:F", "GO:0030632:D-alanine biosynthetic process:P"], "name": "Ala_racemase", "pathway_ids": ["PWY-7383", "PWY-8040", "PWY-8443", "PWY-8072"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-8443:t:cyclosporin A biosynthesis", "PWY-8072:t:alanine racemization"], "type": "Family"}, "IPR000823": {"description": "Plant peroxidase", "go_ids": ["GO:0004601", "GO:0006979", "GO:0020037"], "go_terms": ["GO:0004601:peroxidase activity:F", "GO:0006979:response to oxidative stress:P", "GO:0020037:heme binding:F"], "name": "Peroxidase_pln", "pathway_ids": ["PWY-5466", "PWY-6824", "PWY-5461", "PWY-7445", "PWY-8249", "PWY-7214", "PWY-5469"], "pathways": ["PWY-5466:t:matairesinol biosynthesis", "PWY-6824:t:justicidin B biosynthesis", "PWY-5461:t:betanidin degradation", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-8249:t:xanthommatin biosynthesis", "PWY-7214:t:baicalein degradation (hydrogen peroxide detoxification)", "PWY-5469:t:sesamin biosynthesis"], "type": "Family"}, "IPR000825": {"description": "SUF system FeS cluster assembly, SufBD core domain", "go_ids": ["GO:0016226"], "go_terms": ["GO:0016226:iron-sulfur cluster assembly:P"], "name": "SUF_FeS_clus_asmbl_SufBD_core", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000826": {"description": "Formyl peptide receptor-related", "go_ids": ["GO:0007186", "GO:0016020"], "go_terms": ["GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "Formyl_rcpt-rel", "pathway_ids": ["R-MMU-416476", "R-HSA-6798695", "R-MMU-444473", "R-MMU-977606", "R-HSA-375276", "R-BTA-373076", "R-HSA-391906", "R-HSA-9660826", "R-HSA-373076", "R-HSA-418555", "R-MMU-391906", "R-HSA-416476", "R-MMU-375276", "R-BTA-391906", "R-RNO-391906", "R-MMU-418594", "R-MMU-391908", "R-RNO-418594", "R-RNO-977606", "R-BTA-416476", "R-RNO-391908", "R-HSA-418594", "R-HSA-391908", "R-SSC-373076", "R-HSA-977606", "R-RNO-375276", "R-RNO-373076", "R-HSA-444473", "R-MMU-6798695", "R-RNO-416476", "R-HSA-6783783", "R-RNO-6798695", "R-MMU-373076"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-HSA-391906:r:Leukotriene receptors", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-391906:r:Leukotriene receptors", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-BTA-391906:r:Leukotriene receptors", "R-RNO-391906:r:Leukotriene receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-391908:r:Prostanoid ligand receptors", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-BTA-416476:r:G alpha (q) signalling events", "R-RNO-391908:r:Prostanoid ligand receptors", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-391908:r:Prostanoid ligand receptors", "R-SSC-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-RNO-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-6783783:r:Interleukin-10 signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-373076:r:Class A/1 (Rhodopsin-like receptors)"], "type": "Family"}, "IPR000829": {"description": "DAGK family", "go_ids": ["GO:0008654", "GO:0016020", "GO:0016301"], "go_terms": ["GO:0008654:phospholipid biosynthetic process:P", "GO:0016020:membrane:C", "GO:0016301:kinase activity:F"], "name": "DAGK", "pathway_ids": ["PWY-7039", "PWY-7817"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)"], "type": "Family"}, "IPR000831": {"description": "Trp repressor", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Trp_repress", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000832": {"description": "GPCR, family 2, secretin-like", "go_ids": ["GO:0004930", "GO:0007186", "GO:0016020"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F", "GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "GPCR_2_secretin-like", "pathway_ids": ["R-HSA-6798695", "R-MMU-416476", "R-HSA-373080", "R-DME-350379", "R-MMU-9856530", "R-DRE-419812", "R-CEL-6798695", "R-DME-9619665", "R-HSA-9619665", "R-DME-350368", "R-HSA-416476", "R-MMU-373080", "R-BTA-420092", "R-DME-350376", "R-MMU-381676", "R-HSA-419812", "R-CFA-373080", "R-RNO-420092", "R-DME-350411", "R-HSA-420092", "R-DRE-9856530", "R-RNO-419812", "R-MMU-163359", "R-RNO-416476", "R-HSA-163359", "R-DME-450728", "R-MMU-5683826", "R-DRE-9619665", "R-CEL-373080", "R-CEL-9619665", "R-DME-6798695", "R-DME-373080", "R-HSA-418555", "R-DME-350480", "R-RNO-163359", "R-RNO-5683826", "R-RNO-381676", "R-HSA-422085", "R-MMU-420092", "R-RNO-9856530", "R-MMU-419812", "R-CEL-419812", "R-HSA-187024", "R-HSA-381676", "R-BTA-418555", "R-HSA-5683826", "R-MMU-6798695", "R-RNO-373080", "R-HSA-9856530", "R-MMU-9619665", "R-MMU-418555"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DRE-419812:r:Calcitonin-like ligand receptors", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-BTA-420092:r:Glucagon-type ligand receptors", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-419812:r:Calcitonin-like ligand receptors", "R-CFA-373080:r:Class B/2 (Secretin family receptors)", "R-RNO-420092:r:Glucagon-type ligand receptors", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-HSA-420092:r:Glucagon-type ligand receptors", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-419812:r:Calcitonin-like ligand receptors", "R-MMU-163359:r:Glucagon signaling in metabolic regulation", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-5683826:r:Surfactant metabolism", "R-DRE-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-373080:r:Class B/2 (Secretin family receptors)", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-418555:r:G alpha (s) signalling events", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-RNO-163359:r:Glucagon signaling in metabolic regulation", "R-RNO-5683826:r:Surfactant metabolism", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-420092:r:Glucagon-type ligand receptors", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-419812:r:Calcitonin-like ligand receptors", "R-CEL-419812:r:Calcitonin-like ligand receptors", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-418555:r:G alpha (s) signalling events", "R-HSA-5683826:r:Surfactant metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Family"}, "IPR000833": {"description": "Alpha-amylase inhibitor", "go_ids": ["GO:0015066"], "go_terms": ["GO:0015066:alpha-amylase inhibitor activity:F"], "name": "A-amylase_inhib", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000834": {"description": "Peptidase M14, carboxypeptidase A", "go_ids": ["GO:0004181", "GO:0006508", "GO:0008270"], "go_terms": ["GO:0004181:metallocarboxypeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0008270:zinc ion binding:F"], "name": "Peptidase_M14", "pathway_ids": ["R-MMU-163125", "R-MMU-977606", "R-BTA-2022377", "R-HSA-264876", "R-MMU-432722", "R-RNO-2022377", "R-HSA-9925561", "R-RNO-9696273", "R-HSA-2022377", "R-HSA-9696264", "R-HSA-163125", "R-RNO-977606", "R-HSA-8955332", "R-HSA-977606", "R-RNO-9696264", "R-MMU-2022377", "R-MMU-9696264", "R-MMU-9696273", "R-HSA-432722", "R-RNO-432722", "R-HSA-9696273", "R-BTA-977606"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-264876:r:Insulin processing", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi 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"R-DME-6798695", "R-RNO-74217", "R-DDI-73843", "R-HSA-9734195", "R-MMU-73614", "R-SPO-73843", "R-CEL-74217", "R-GGA-419140", "R-SSC-74217", "R-DME-74217", "R-HSA-9748787", "R-DDI-74217", "R-DME-73817", "R-BTA-9748787", "R-HSA-74217", "R-MMU-6798695", "R-SSC-9748787", "R-SCE-73614", "R-HSA-73817", "R-SPO-74217", "R-RNO-6798695", "R-DDI-73614"], "pathways": ["R-MMU-500753:r:Pyrimidine biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-74217:r:Purine salvage", "R-SPO-6798695:r:Neutrophil degranulation", "R-SCE-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-DDI-9748787:r:Azathioprine ADME", "R-SPO-73614:r:Pyrimidine salvage", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-73843:r:5-Phosphoribose 1-diphosphate 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IMP", "R-SSC-74217:r:Purine salvage", "R-DME-74217:r:Purine salvage", "R-HSA-9748787:r:Azathioprine ADME", "R-DDI-74217:r:Purine salvage", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-9748787:r:Azathioprine ADME", "R-HSA-74217:r:Purine salvage", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-9748787:r:Azathioprine ADME", "R-SCE-73614:r:Pyrimidine salvage", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-74217:r:Purine salvage", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-73614:r:Pyrimidine salvage"], "type": "Domain"}, "IPR000837": {"description": "AP-1 transcription factor", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006357"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "AP-1", "pathway_ids": ["R-HSA-9768919", "R-GGA-2559580", "R-HSA-2559580", "R-HSA-2871796", "R-DME-209425", "R-GGA-9018519", "R-HSA-2559582", "R-HSA-6796648", "R-RNO-9018519", "R-BTA-9018519", "R-MMU-2871796", "R-CEL-450341", "R-HSA-450341", "R-DME-2559580", "R-HSA-380994", "R-DME-209409", "R-BTA-2871796", "R-DME-209394", "R-HSA-9018519", "R-DME-450341", "R-GGA-2871796", "R-CEL-2871796", "R-BTA-2559580", "R-HSA-6785807", "R-HSA-9634638", "R-CEL-2559580", "R-BTA-450341", "R-MMU-2559580", "R-HSA-9648895", "R-DME-2871796", "R-HSA-9909649", "R-RNO-2559580", "R-GGA-450341", "R-MMU-450341", "R-HSA-9031628", "R-RNO-450341", "R-RNO-2871796", "R-HSA-9633012"], "pathways": ["R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-GGA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-DME-209425:r:Transcriptional activtion by AP-1 transcription factor", "R-GGA-9018519:r:Estrogen-dependent gene expression", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-CEL-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-450341:r:Activation of the AP-1 family of transcription factors", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-DME-209409:r:Formation of the nuclear AP-1 transcription factor 'scaffolding complex'", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-450341:r:Activation of the AP-1 family of transcription factors", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-CEL-2871796:r:FCERI mediated MAPK activation", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-BTA-450341:r:Activation of the AP-1 family of transcription factors", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-GGA-450341:r:Activation of the AP-1 family of transcription factors", "R-MMU-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-9031628:r:NGF-stimulated transcription", "R-RNO-450341:r:Activation of the AP-1 family of transcription factors", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000839": {"description": "Porin, Oms28 type", "go_ids": [], "go_terms": [], "name": "Porin_Oms28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000840": {"description": "Gamma-retroviral matrix protein", "go_ids": [], "go_terms": [], "name": "G_retro_matrix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000841": {"description": "Peptidase M23A, B-lytic metalloendopeptidase", "go_ids": ["GO:0004222", "GO:0006508"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_M23A_Blytic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000843": {"description": "LacI-type HTH domain", "go_ids": ["GO:0006355", "GO:0003677"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F"], "name": "HTH_LacI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000845": {"description": "Nucleoside phosphorylase domain", "go_ids": ["GO:0003824", "GO:0009116"], "go_terms": ["GO:0003824:catalytic 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"R-PFA-73614:r:Pyrimidine salvage", "R-HSA-1237112:r:Methionine salvage pathway", "R-MMU-9755088:r:Ribavirin ADME", "R-SCE-74217:r:Purine salvage", "R-BTA-1237112:r:Methionine salvage pathway", "R-SPO-1237112:r:Methionine salvage pathway", "R-HSA-74259:r:Purine catabolism", "R-MMU-74217:r:Purine salvage", "R-MMU-1237112:r:Methionine salvage pathway", "R-HSA-9755088:r:Ribavirin ADME", "R-HSA-9735763:r:Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine", "R-CEL-73621:r:Pyrimidine catabolism", "R-CEL-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-CEL-73614:r:Pyrimidine salvage", "R-HSA-73614:r:Pyrimidine salvage", "R-RNO-74217:r:Purine salvage", "R-RNO-9755088:r:Ribavirin ADME", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-DRE-1237112:r:Methionine salvage pathway", "R-SCE-1237112:r:Methionine salvage pathway", "R-SPO-9755088:r:Ribavirin ADME", "R-HSA-74217:r:Purine salvage", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-74259:r:Purine catabolism", "R-SCE-74259:r:Purine catabolism", "R-SPO-74259:r:Purine catabolism", "R-SPO-74217:r:Purine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR000846": {"description": "Dihydrodipicolinate reductase, N-terminal", "go_ids": ["GO:0008839", "GO:0009085"], "go_terms": ["GO:0008839:4-hydroxy-tetrahydrodipicolinate reductase activity:F", "GO:0009085:L-lysine biosynthetic process:P"], "name": "DapB_N", "pathway_ids": ["PWY-5097", "PWY-2942", "PWY-2941"], "pathways": ["PWY-5097:t:L-lysine biosynthesis VI", "PWY-2942:t:L-lysine biosynthesis III", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Domain"}, "IPR000847": {"description": "LysR, HTH, N-terminal domain", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding 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megakaryocyte development and platelet production", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-983231:r:Factors involved in 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"R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000852": {"description": "Glycoside hydrolase, family 52", "go_ids": ["GO:0005975", "GO:0009044"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0009044:xylan 1,4-beta-xylosidase activity:F"], "name": "Glyco_hydro_52", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000853": {"description": "Metallothionein, family 6, nematoda", "go_ids": [], "go_terms": [], "name": "Metalthion_nemt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000855": {"description": "Peptidase C5, adenain", "go_ids": ["GO:0004197", "GO:0006508"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_C5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000857": {"description": "MyTH4 domain", "go_ids": ["GO:0005856"], "go_terms": ["GO:0005856:cytoskeleton:C"], "name": "MyTH4_dom", "pathway_ids": ["R-HSA-9013405", "R-MMU-9035034", "R-HSA-9664422", "R-MMU-9013106", "R-MMU-8980692", "R-HSA-9662361", "R-MMU-9013408", "R-MMU-2453902", "R-CEL-2453902", "R-MMU-9013148", "R-MMU-9013404", "R-HSA-9013106", "R-HSA-373752", "R-HSA-2029482", "R-MMU-2029482", "R-DDI-9013422", "R-RNO-2029482", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-428543", "R-HSA-8980692", "R-HSA-9662360", "R-DME-2453902", "R-HSA-9035034", "R-MMU-9013026", "R-HSA-9013148", "R-HSA-9013026", "R-HSA-9013408", "R-MMU-9013149", "R-DDI-9013418", "R-HSA-2453902"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Domain"}, "IPR000858": {"description": "S-locus glycoprotein domain", "go_ids": ["GO:0048544"], "go_terms": ["GO:0048544:recognition of pollen:P"], "name": "S_locus_glycoprot_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000859": {"description": "CUB domain", "go_ids": [], "go_terms": [], "name": "CUB_dom", "pathway_ids": ["R-DRE-194306", "R-RNO-3772470", "R-HSA-2855086", "R-HSA-1650814", "R-MMU-166662", "R-MMU-2243919", "R-MMU-2214320", "R-RNO-977606", "R-MMU-975634", "R-RNO-399954", "R-DME-2214320", "R-RNO-173623", "R-MMU-399954", "R-HSA-399955", "R-HSA-3359462", "R-DRE-1650814", "R-HSA-166663", "R-HSA-447038", "R-MMU-1474228", "R-HSA-1474228", "R-DRE-9619665", "R-DME-1650814", "R-RNO-445144", "R-CEL-2214320", "R-MMU-399955", "R-HSA-9694614", "R-MMU-445144", "R-RNO-8964011", "R-DRE-5362798", "R-HSA-194306", "R-HSA-447041", "R-RNO-196791", "R-RNO-2855086", "R-HSA-5683826", "R-HSA-399954", "R-DRE-399956", "R-MMU-6798695", "R-HSA-445144", "R-HSA-9758881", "R-MMU-186797", "R-CEL-1650814", "R-MMU-399956", "R-MMU-194306", "R-RNO-194306", "R-HSA-8964011", "R-HSA-399956", "R-HSA-201681", "R-MMU-3772470", "R-HSA-9705671", "R-HSA-6809371", "R-HSA-3000480", "R-DRE-2243919", "R-RNO-166662", "R-MMU-2855086", "R-HSA-9619665", "R-MMU-3000480", "R-MMU-173623", "R-GGA-186797", "R-HSA-196791", "R-CEL-1474228", "R-HSA-5362798", "R-RNO-9758881", "R-HSA-977606", "R-HSA-3359463", "R-MMU-5683826", "R-HSA-1442490", "R-HSA-3772470", "R-RNO-1650814", "R-HSA-2214320", "R-HSA-8963896", "R-MMU-977606", "R-RNO-399956", "R-HSA-5339717", "R-HSA-376176", "R-RNO-186797", "R-RNO-5683826", "R-DME-2243919", "R-DME-1474228", "R-MMU-8963896", "R-MMU-1650814", "R-MMU-5362798", "R-RNO-399955", "R-HSA-166662", "R-MMU-9619665", "R-MMU-1442490", "R-HSA-975634", "R-HSA-186797", "R-HSA-6798695", "R-HSA-2243919", "R-HSA-173623", "R-DRE-399954", "R-HSA-9920588", "R-RNO-2243919", "R-CEL-6798695"], "pathways": ["R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-166662:r:Lectin pathway of complement activation", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-MMU-2214320:r:Anchoring fibril formation", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-975634:r:Retinoid metabolism and transport", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-2214320:r:Anchoring fibril formation", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-3359462:r:Defective AMN causes MGA1", "R-DRE-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-447038:r:NrCAM interactions", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DRE-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-445144:r:Signal transduction by L1", "R-CEL-2214320:r:Anchoring fibril formation", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9694614:r:Attachment and Entry", "R-MMU-445144:r:Signal transduction by L1", "R-RNO-8964011:r:HDL clearance", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-447041:r:CHL1 interactions", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-MMU-186797:r:Signaling by PDGF", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-8964011:r:HDL clearance", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-DRE-2243919:r:Crosslinking of collagen fibrils", "R-RNO-166662:r:Lectin pathway of complement activation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-GGA-186797:r:Signaling by PDGF", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-3359463:r:Defective CUBN causes MGA1", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-1442490:r:Collagen degradation", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-HSA-376176:r:Signaling by ROBO receptors", "R-RNO-186797:r:Signaling by PDGF", "R-RNO-5683826:r:Surfactant metabolism", "R-DME-2243919:r:Crosslinking of collagen fibrils", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-8963896:r:HDL assembly", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-166662:r:Lectin pathway of complement activation", "R-MMU-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-1442490:r:Collagen degradation", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-2243919:r:Crosslinking of collagen fibrils", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR000860": {"description": "Porphobilinogen deaminase", "go_ids": ["GO:0004418", "GO:0033014"], "go_terms": ["GO:0004418:hydroxymethylbilane synthase activity:F", "GO:0033014:tetrapyrrole biosynthetic process:P"], "name": "HemC", "pathway_ids": ["PWY-5188", "PWY-5189", "R-RNO-189451", "R-BTA-189451", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "PWY-5189:t:tetrapyrrole biosynthesis II (from glycine)", "R-RNO-189451:r:Heme biosynthesis", "R-BTA-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Family"}, "IPR000863": {"description": "Sulfotransferase domain", "go_ids": ["GO:0008146"], "go_terms": ["GO:0008146:sulfotransferase activity:F"], "name": "Sulfotransferase_dom", "pathway_ids": ["R-HSA-1989781", "R-RNO-2022923", "R-MMU-2022870", "R-MMU-9753281", "R-CEL-2022928", "R-RNO-9753281", "R-CFA-9753281", "R-MMU-913709", "R-DRE-9753281", "R-DRE-156584", "R-HSA-3595172", "R-MMU-156584", "R-BTA-156584", "R-DRE-2022854", "R-MMU-2022928", "R-HSA-2022928", "R-MMU-2022923", "R-RNO-2022870", "R-RNO-156584", "R-HSA-381038", "R-HSA-2022870", "R-HSA-9753281", "R-MMU-2022854", "R-CEL-156584", "R-DME-2022928", "R-HSA-2022854", "R-HSA-2022923", "R-HSA-3656225", "R-CFA-156584", "R-RNO-2022928", "R-RNO-2022854", "R-CEL-9753281", "R-HSA-156584", "R-BTA-9753281", "R-HSA-913709"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-MMU-9753281:r:Paracetamol ADME", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-RNO-9753281:r:Paracetamol ADME", "R-CFA-9753281:r:Paracetamol ADME", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-DRE-9753281:r:Paracetamol ADME", "R-DRE-156584:r:Cytosolic sulfonation of small molecules", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-MMU-156584:r:Cytosolic sulfonation of small molecules", "R-BTA-156584:r:Cytosolic sulfonation of small molecules", "R-DRE-2022854:r:Keratan sulfate biosynthesis", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-RNO-156584:r:Cytosolic sulfonation of small molecules", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-HSA-9753281:r:Paracetamol ADME", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-CEL-156584:r:Cytosolic sulfonation of small molecules", "R-DME-2022928:r:HS-GAG biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-CFA-156584:r:Cytosolic sulfonation of small molecules", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-CEL-9753281:r:Paracetamol ADME", "R-HSA-156584:r:Cytosolic sulfonation of small molecules", "R-BTA-9753281:r:Paracetamol ADME", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Domain"}, "IPR000864": {"description": "Proteinase inhibitor I13, potato inhibitor I", "go_ids": ["GO:0004867", "GO:0009611"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F", "GO:0009611:response to wounding:P"], "name": "Prot_inh_pot1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000866": {"description": "Alkyl hydroperoxide reductase subunit C/Thiol specific antioxidant", "go_ids": ["GO:0016209", "GO:0016491"], "go_terms": ["GO:0016209:antioxidant activity:F", "GO:0016491:oxidoreductase activity:F"], "name": "AhpC/TSA", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-SSC-6798695", "R-SCE-5628897", "R-GGA-3000471", "R-SCE-6798695", "R-BTA-6798695", "R-HSA-8862803", "R-HSA-5628897", "R-RNO-3299685", "R-RNO-3000471", "R-SCE-9818027", "R-BTA-3299685", "R-HSA-3000471", "R-HSA-1222541", "R-MMU-5628897", "R-MMU-9818027", "R-HSA-1222387", "R-CEL-9818027", "R-BTA-3000471", "R-DDI-6798695", "R-HSA-3299685", "R-DDI-5628897", "R-GGA-3299685", "R-HSA-1222538", "R-MMU-3000471", "R-SPO-5628897", "R-CEL-5628897", "R-RNO-5628897", "R-SSC-3299685", "R-BTA-9818027", "R-CEL-3299685", "R-MMU-3299685", "R-SPO-9818027", "R-DME-9818027", "R-BTA-5628897", "R-RNO-9818027", "R-GGA-5628897", "R-PFA-6798695", "R-DDI-9818027", "R-MMU-6798695", "R-GGA-9818027", "R-DME-3299685", "R-DME-5628897", "R-RNO-6798695", "R-HSA-9818027"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-3000471:r:Scavenging by Class B Receptors", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-SCE-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-HSA-1222541:r:Cell redox homeostasis", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages", "R-CEL-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-BTA-3000471:r:Scavenging by Class B Receptors", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-DME-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-PFA-6798695:r:Neutrophil degranulation", "R-DDI-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-MMU-6798695:r:Neutrophil degranulation", "R-GGA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes"], "type": "Domain"}, "IPR000867": {"description": "Insulin-like growth factor-binding protein, IGFBP", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "IGFBP-like", "pathway_ids": ["R-HSA-2032785", "R-HSA-1474228", "R-SSC-381426", "R-MMU-6803211", "R-XTR-381426", "R-SSC-8957275", "R-DRE-1474228", "R-HSA-8951671", "R-RNO-1474228", "R-HSA-2559582", "R-MMU-8957275", "R-RNO-381426", "R-BTA-8957275", "R-HSA-380994", "R-HSA-9615017", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-GGA-8957275", "R-GGA-381426", "R-DRE-381426", "R-HSA-8957275", "R-HSA-6803211", "R-RNO-6803211", "R-BTA-6803211", "R-HSA-381426", "R-MMU-1474228"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-XTR-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-RNO-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-BTA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR000868": {"description": "Isochorismatase-like domain", "go_ids": [], "go_terms": [], "name": "Isochorismatase-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000869": {"description": "Fungi-IV metallothionein, family 11", "go_ids": ["GO:0005507"], "go_terms": ["GO:0005507:copper ion binding:F"], "name": "Metalthion_11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000870": {"description": "Homoserine kinase", "go_ids": ["GO:0004413", "GO:0005524", "GO:0006566"], "go_terms": ["GO:0004413:homoserine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006566:L-threonine metabolic process:P"], "name": "Homoserine_kinase", "pathway_ids": ["PWY-702"], "pathways": ["PWY-702:t:L-methionine biosynthesis II"], "type": "Family"}, "IPR000871": {"description": "Beta-lactamase, class-A", "go_ids": ["GO:0008800", "GO:0030655", "GO:0046677"], "go_terms": ["GO:0008800:beta-lactamase activity:F", "GO:0030655:beta-lactam antibiotic catabolic process:P", "GO:0046677:response to antibiotic:P"], "name": "Beta-lactam_class-A", "pathway_ids": ["R-HSA-9913143"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance"], "type": "Family"}, "IPR000872": {"description": "Tafazzin", "go_ids": ["GO:0016746", "GO:0006644"], "go_terms": ["GO:0016746:acyltransferase activity:F", "GO:0006644:phospholipid metabolic process:P"], "name": "Tafazzin", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-DDI-1482798", "R-DRE-1482798", "R-DDI-1268020", "R-SCE-1482798", "R-DRE-1268020", "R-HSA-1268020", "R-MMU-1482798", "R-SCE-1268020", "R-DME-1268020", "R-DME-1482798", "R-HSA-1482798"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-DDI-1482798:r:Acyl chain remodeling of CL", "R-DRE-1482798:r:Acyl chain remodeling of CL", "R-DDI-1268020:r:Mitochondrial protein import", "R-SCE-1482798:r:Acyl chain remodeling of CL", "R-DRE-1268020:r:Mitochondrial protein import", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-SCE-1268020:r:Mitochondrial protein import", "R-DME-1268020:r:Mitochondrial protein import", "R-DME-1482798:r:Acyl chain remodeling of CL", "R-HSA-1482798:r:Acyl chain remodeling of CL"], "type": "Family"}, "IPR000873": {"description": "AMP-dependent synthetase/ligase domain", "go_ids": [], "go_terms": [], "name": "AMP-dep_synth/lig_dom", "pathway_ids": ["R-HSA-6798695", "R-HSA-1989781", "R-DDI-71384", "R-HSA-804914", "R-HSA-2151201", "R-DRE-77111", "R-HSA-389599", "R-HSA-177128", "R-RNO-2046106", "R-MMU-75876", "R-MTU-9635470", "R-HSA-2046105", "R-SCE-71384", "R-MMU-389599", "R-HSA-9841922", "R-RNO-9033241", "R-DRE-77289", "R-DME-71384", "R-RNO-77289", "R-RNO-434313", "R-MMU-9749641", "R-HSA-5619108", "R-HSA-77352", "R-SPO-75876", "R-HSA-77289", "R-MMU-434313", "R-HSA-193775", "R-HSA-177162", "R-RNO-77111", "R-BTA-77289", "R-HSA-71384", "R-MMU-2151201", "R-SCE-434313", "R-SPO-71384", "R-SCE-75876", "R-RNO-193775", "R-SCE-2046105", "R-RNO-389599", "R-RNO-177135", "R-HSA-75105", "R-HSA-390247", "R-MMU-390247", "R-HSA-9749641", "R-MMU-6798695", "R-RNO-193368", "R-MMU-177128", "R-MMU-77289", "R-DME-75876", "R-RNO-177128", "R-HSA-2046106", "R-RNO-6798695", "R-RNO-2046105", "R-MMU-177135", "R-RNO-75876", "R-MMU-193775", "R-BTA-77111", "R-SCE-2046106", "R-HSA-193368", "R-MMU-77111", "R-RNO-75105", "R-HSA-177135", "R-DDI-77111", "R-HSA-77111", "R-RNO-159418", "R-DDI-75876", "R-DDI-2046105", "R-CEL-77111", "R-RNO-804914", "R-MMU-2046106", "R-MMU-193368", "R-DDI-2046106", "R-HSA-2142753", "R-RNO-177162", "R-MMU-9033241", "R-MMU-177162", "R-MMU-75105", "R-MMU-804914", "R-HSA-434313", "R-RNO-9749641", "R-BTA-75876", "R-HSA-159418", "R-HSA-9033241", "R-SPO-434313", "R-HSA-75876", "R-MMU-159418", "R-MMU-2046105", "R-RNO-390247", "R-MMU-71384"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-71384:r:Ethanol oxidation", "R-HSA-804914:r:Transport of fatty acids", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DRE-77111:r:Synthesis of Ketone Bodies", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-HSA-177128:r:Conjugation of salicylate with glycine", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-SCE-71384:r:Ethanol oxidation", "R-MMU-389599:r:Alpha-oxidation of phytanate", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-9033241:r:Peroxisomal protein import", "R-DRE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-71384:r:Ethanol oxidation", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-5619108:r:Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SPO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-HSA-177162:r:Conjugation of phenylacetate with glutamine", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-71384:r:Ethanol oxidation", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SCE-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-SPO-71384:r:Ethanol oxidation", "R-SCE-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-RNO-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-SCE-2046105:r:Linoleic acid (LA) metabolism", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-RNO-177135:r:Conjugation of benzoate with glycine", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-177128:r:Conjugation of salicylate with glycine", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-RNO-177128:r:Conjugation of salicylate with glycine", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-177135:r:Conjugation of benzoate with glycine", "R-RNO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-BTA-77111:r:Synthesis of Ketone Bodies", "R-SCE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-177135:r:Conjugation of benzoate with glycine", "R-DDI-77111:r:Synthesis of Ketone Bodies", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-RNO-159418:r:Recycling of bile acids and salts", "R-DDI-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-DDI-2046105:r:Linoleic acid (LA) metabolism", "R-CEL-77111:r:Synthesis of Ketone Bodies", "R-RNO-804914:r:Transport of fatty acids", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-2142753:r:Arachidonate metabolism", "R-RNO-177162:r:Conjugation of phenylacetate with glutamine", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-177162:r:Conjugation of phenylacetate with glutamine", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-804914:r:Transport of fatty acids", "R-HSA-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-RNO-9749641:r:Aspirin ADME", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9033241:r:Peroxisomal protein import", "R-SPO-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-71384:r:Ethanol oxidation"], "type": "Domain"}, "IPR000874": {"description": "Bombesin/neuromedin-B/ranatensin peptide family", "go_ids": ["GO:0007218"], "go_terms": ["GO:0007218:neuropeptide signaling pathway:P"], "name": "Bombesin", "pathway_ids": ["R-MMU-416476", "R-HSA-375276", "R-MMU-381771", "R-HSA-416476", "R-MMU-375276", "R-SSC-416476", "R-BTA-416476", "R-CFA-381771", "R-CFA-375276", "R-SSC-375276", "R-SSC-381771", "R-BTA-381771", "R-RNO-375276", "R-RNO-381771", "R-CFA-416476", "R-HSA-381771", "R-RNO-416476", "R-BTA-375276"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-SSC-416476:r:G alpha (q) signalling events", "R-BTA-416476:r:G alpha (q) signalling events", "R-CFA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-CFA-375276:r:Peptide ligand-binding receptors", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-SSC-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-BTA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-RNO-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-CFA-416476:r:G alpha (q) signalling events", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-RNO-416476:r:G alpha (q) signalling events", "R-BTA-375276:r:Peptide ligand-binding receptors"], "type": "Family"}, "IPR000875": {"description": "Cecropin-like", "go_ids": ["GO:0005576", "GO:0019731"], "go_terms": ["GO:0005576:extracellular 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dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000877": {"description": "Proteinase inhibitor I12, Bowman-Birk", "go_ids": ["GO:0004867", "GO:0005576"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F", "GO:0005576:extracellular region:C"], "name": "Prot_inh_BBI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000878": {"description": "Tetrapyrrole methylase", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "4pyrrol_Mease", "pathway_ids": ["R-SPO-5358493", "R-SCE-5358493", "R-BTA-5358493", "R-DDI-5358493", "R-HSA-5358493", "R-MMU-5358493"], "pathways": ["R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis 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multimer:collagen", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-MMU-8948216:r:Collagen chain trimerization", "R-BTA-1442490:r:Collagen degradation", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-BTA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-3000171:r:Non-integrin membrane-ECM interactions", "R-BTA-186797:r:Signaling by PDGF", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2214320:r:Anchoring fibril formation", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-BTA-8874081:r:MET activates PTK2 signaling", "R-BTA-1566977:r:Fibronectin matrix formation", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-1566977:r:Fibronectin matrix formation", "R-RNO-186797:r:Signaling by PDGF", "R-RNO-1442490:r:Collagen degradation", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-BTA-8948216:r:Collagen chain trimerization", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-419037:r:NCAM1 interactions", "R-MMU-1442490:r:Collagen degradation", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR000887": {"description": "KDPG/KHG aldolase", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "Aldlse_KDPG_KHG", "pathway_ids": ["PWY-7242", "PWY-7562", "PWY-6507", "PWY-2221", "PWY-7310"], "pathways": ["PWY-7242:t:D-fructuronate degradation", "PWY-7562:t:3,6-anhydro-alpha-L-galactopyranose degradation", "PWY-6507:t:4-deoxy-L-threo-hex-4-enopyranuronate degradation", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-7310:t:D-glucosaminate degradation"], "type": "Family"}, "IPR000888": {"description": "dTDP-4-dehydrorhamnose 3,5-epimerase-like", "go_ids": ["GO:0008830"], "go_terms": ["GO:0008830:dTDP-4-dehydrorhamnose 3,5-epimerase activity:F"], "name": "RmlC-like", "pathway_ids": ["PWY-8380", "PWY-7814", "PWY-7301"], "pathways": ["PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis"], "type": "Family"}, "IPR000889": {"description": "Glutathione peroxidase", "go_ids": ["GO:0006979", "GO:0004601"], "go_terms": ["GO:0006979:response to oxidative stress:P", "GO:0004601:peroxidase activity:F"], "name": "Glutathione_peroxidase", "pathway_ids": ["PWY-4081", "R-HSA-9018676", "R-BTA-9018676", "R-RNO-9023661", "R-CEL-2142770", "R-CEL-2142712", "R-HSA-5628897", "R-RNO-3299685", "R-MMU-9023661", "R-HSA-2142712", "R-BTA-9020265", "R-RNO-2142712", "R-BTA-3299685", "R-SSC-9020265", "R-HSA-9023661", "R-SSC-9018896", "R-HSA-9018896", "R-MMU-5628897", "R-BTA-9023661", "R-BTA-2142712", "R-RNO-9018676", "R-MMU-9018676", "R-SSC-2142770", "R-HSA-3299685", "R-DRE-3299685", "R-BTA-9018896", "R-HSA-9020265", "R-RNO-5628897", "R-CEL-5628897", "R-SSC-3299685", "R-RNO-2142770", "R-CEL-3299685", "R-MMU-3299685", "R-HSA-2142688", "R-MMU-2142770", "R-SSC-9023661", "R-MMU-9020265", "R-SSC-9018676", "R-SSC-2142712", "R-HSA-2142770", "R-MMU-2142712", "R-RNO-9020265", "R-RNO-9018896", "R-MMU-9018896"], "pathways": ["PWY-4081:t:glutathione-peroxide redox reactions", "R-HSA-9018676:r:Biosynthesis of D-series resolvins", "R-BTA-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-CEL-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-CEL-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-BTA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SSC-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-HSA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SSC-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-BTA-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-SSC-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-DRE-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-MMU-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-SSC-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-SSC-9018676:r:Biosynthesis of D-series resolvins", "R-SSC-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-HSA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-MMU-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins"], "type": "Family"}, "IPR000890": {"description": "Aliphatic acid kinase, short-chain", "go_ids": ["GO:0016301", "GO:0016310", "GO:0016774"], "go_terms": ["GO:0016301:kinase activity:F", "GO:0016310:phosphorylation:P", "GO:0016774:phosphotransferase activity, carboxyl group as acceptor:F"], "name": "Aliphatic_acid_kin_short-chain", "pathway_ids": ["PWY-8086", "PWY-8377", "PWY-5497", "PWY-8303", "PWY-8015", 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Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000894": {"description": "Ribulose bisphosphate carboxylase small subunit, domain", "go_ids": [], "go_terms": [], "name": "RuBisCO_ssu_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000895": {"description": "Transthyretin/hydroxyisourate hydrolase", "go_ids": [], "go_terms": [], "name": "Transthyretin/HIU_hydrolase", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-SPO-6798695", "R-SSC-6798695", "R-SSC-2453902", "R-HSA-977225", "R-CEL-6798695", "R-HSA-9918449", "R-HSA-3000171", "R-MMU-2453902", "R-BTA-6798695", "R-CEL-975634", "R-RNO-2453902", "R-XTR-6798695", "R-BTA-975634", "R-MMU-975634", "R-SSC-975634", "R-MMU-6798695", "R-RNO-975634", "R-BTA-2453902", "R-HSA-975634", "R-XTR-975634", "R-CEL-3000171", "R-XTR-2453902", "R-HSA-2453902"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-SSC-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-977225:r:Amyloid fiber formation", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9918449:r:Defective visual phototransduction due to STRA6 loss of function", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-975634:r:Retinoid metabolism and transport", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-XTR-6798695:r:Neutrophil degranulation", "R-BTA-975634:r:Retinoid metabolism and transport", "R-MMU-975634:r:Retinoid metabolism and transport", "R-SSC-975634:r:Retinoid metabolism and transport", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975634:r:Retinoid metabolism and transport", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-975634:r:Retinoid metabolism and transport", "R-XTR-975634:r:Retinoid metabolism and transport", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-XTR-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Family"}, "IPR000896": {"description": "Hemocyanin/hexamerin middle domain", "go_ids": [], "go_terms": [], "name": "Hemocyanin/hexamerin_mid_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000897": {"description": "Signal recognition particle, SRP54 subunit, GTPase domain", "go_ids": ["GO:0005525", "GO:0006614"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P"], "name": "SRP54_GTPase_dom", "pathway_ids": ["R-HSA-1799339", "R-DRE-1799339", "R-HSA-381038", "R-SPO-1799339", "R-SCE-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-RNO-1799339", "R-BTA-1799339", "R-MMU-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Domain"}, "IPR000898": {"description": "Indoleamine 2,3-dioxygenase", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "Indolamine_dOase", "pathway_ids": ["R-HSA-71240", "R-RNO-71240", "R-SCE-71240", "R-MMU-71240"], "pathways": ["R-HSA-71240:r:Tryptophan catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-SCE-71240:r:Tryptophan catabolism", "R-MMU-71240:r:Tryptophan catabolism"], "type": "Family"}, "IPR000900": {"description": "Nebulin repeat", "go_ids": [], "go_terms": [], "name": "Nebulin_repeat", "pathway_ids": ["R-HSA-390522"], "pathways": ["R-HSA-390522:r:Striated Muscle Contraction"], "type": "Repeat"}, "IPR000903": {"description": "Glycylpeptide N-tetradecanoyltransferase", "go_ids": ["GO:0004379", 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"R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-5419276:r:Mitochondrial translation termination", "R-CFA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-CFA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CFA-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CFA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000912": {"description": "Herpesvirus major capsid protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Herpes_MCP", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR000914": {"description": "Solute-binding protein family 5 domain", "go_ids": [], "go_terms": [], "name": "SBP_5_dom", "pathway_ids": ["R-HSA-9927020", "R-HSA-1222538"], "pathways": ["R-HSA-9927020:r:Heme assimilation", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Domain"}, "IPR000915": {"description": "Large ribosomal subunit protein eL6", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "60S_ribosomal_eL6", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954716", "R-CEL-9954714", "R-RNO-975957", "R-HSA-1799339", "R-SPO-9954709", "R-MMU-6791226", "R-SPO-975956", "R-HSA-2408557", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-HSA-9954716", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR000916": {"description": "Bet v I/Major latex protein", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "Bet_v_I/MLP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000917": {"description": "Sulfatase, N-terminal", "go_ids": [], "go_terms": [], "name": "Sulfatase_N", "pathway_ids": ["R-HSA-6798695", "R-RNO-9840310", "R-MMU-9840310", "R-SPO-6798695", "R-DRE-9840310", "R-MMU-2024096", "R-CFA-2022857", "R-CFA-9840310", "R-BTA-6798695", "R-HSA-1663150", "R-HSA-9953078", "R-MMU-1663150", "R-HSA-2206285", "R-RNO-196071", "R-MMU-196071", "R-BTA-9840310", "R-HSA-2206296", "R-HSA-196071", "R-RNO-2024101", "R-HSA-2024096", "R-SCE-162710", "R-MMU-432720", "R-HSA-2206290", "R-SPO-2022857", "R-HSA-2206305", "R-HSA-2024101", "R-HSA-9840310", "R-HSA-432720", "R-HSA-2022857", "R-HSA-2206307", "R-BTA-1663150", "R-RNO-2022857", "R-MMU-2022857", "R-MMU-2024101", "R-MMU-6798695", "R-DRE-1663150", "R-SPO-9840310", "R-CFA-6798695", "R-CFA-1663150", "R-RNO-1663150", "R-RNO-6798695", "R-SPO-196071"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-9840310:r:Glycosphingolipid catabolism", "R-MMU-2024096:r:HS-GAG degradation", "R-CFA-2022857:r:Keratan sulfate degradation", "R-CFA-9840310:r:Glycosphingolipid catabolism", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-1663150:r:The activation of arylsulfatases", "R-HSA-9953078:r:MPS II - Hunter syndrome (CS/DS degradation)", "R-MMU-1663150:r:The activation of arylsulfatases", "R-HSA-2206285:r:MPS VI - Maroteaux-Lamy syndrome", "R-RNO-196071:r:Metabolism of steroid hormones", "R-MMU-196071:r:Metabolism of steroid hormones", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-HSA-2206296:r:MPS II - Hunter syndrome (HS-GAG degradation)", "R-HSA-196071:r:Metabolism of steroid hormones", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-2024096:r:HS-GAG degradation", "R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-2206290:r:MPS IV - Morquio syndrome A", "R-SPO-2022857:r:Keratan sulfate degradation", "R-HSA-2206305:r:MPS IIID - Sanfilippo syndrome D", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-HSA-2206307:r:MPS IIIA - Sanfilippo syndrome A", "R-BTA-1663150:r:The activation of arylsulfatases", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-1663150:r:The activation of arylsulfatases", "R-SPO-9840310:r:Glycosphingolipid catabolism", "R-CFA-6798695:r:Neutrophil degranulation", "R-CFA-1663150:r:The activation of arylsulfatases", "R-RNO-1663150:r:The activation of arylsulfatases", "R-RNO-6798695:r:Neutrophil degranulation", "R-SPO-196071:r:Metabolism of steroid hormones"], "type": "Domain"}, "IPR000920": {"description": "Myelin P0 protein-related", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Myelin_P0-rel", "pathway_ids": ["R-HSA-9717207", "R-MMU-198933", "R-HSA-445095", "R-MMU-202733", "R-HSA-198933", "R-HSA-9619665", "R-HSA-5576892", "R-BTA-5576892", "R-HSA-202733"], "pathways": ["R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR000922": {"description": "D-galactoside/L-rhamnose binding SUEL lectin domain", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "Lectin_gal-bd_dom", "pathway_ids": ["R-DME-9619665", "R-DME-373080", "R-CEL-373080", "R-CEL-9619665", "R-DME-6798695", "R-CEL-6798695"], "pathways": ["R-DME-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-CEL-373080:r:Class B/2 (Secretin family receptors)", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR000923": {"description": "Blue (type 1) copper domain", "go_ids": ["GO:0005507", "GO:0009055"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0009055:electron transfer activity:F"], "name": "BlueCu_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000925": {"description": "Major surface glycoprotein G", "go_ids": ["GO:0055036"], "go_terms": ["GO:0055036:virion membrane:C"], "name": "G_prot", "pathway_ids": ["R-HSA-9828721", "R-HSA-9833110", "R-HSA-9828806", "R-HSA-9820962", "R-HSA-9820960"], "pathways": ["R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry"], "type": "Family"}, "IPR000926": {"description": "GTP cyclohydrolase II, RibA", "go_ids": ["GO:0003935", "GO:0009231"], "go_terms": ["GO:0003935:GTP cyclohydrolase II activity:F", "GO:0009231:riboflavin biosynthetic process:P"], "name": "RibA", "pathway_ids": ["PWY-7539", "PWY-6168", "PWY-7991"], "pathways": ["PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-7991:t:toxoflavin biosynthesis"], "type": "Family"}, "IPR000928": {"description": "SNAP-25 domain", "go_ids": [], "go_terms": [], "name": "SNAP-25_dom", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-6798695", "R-GGA-181429", "R-MMU-181430", "R-RNO-9013149", "R-BTA-6798695", "R-DME-9035034", "R-RNO-212676", "R-HSA-9662360", "R-DRE-6798695", "R-MMU-199992", "R-RNO-9013406", "R-HSA-210500", "R-MMU-449836", "R-MMU-9035034", "R-DME-9013149", "R-HSA-181430", "R-BTA-181430", "R-DME-210500", "R-DME-8980692", "R-GGA-181430", "R-HSA-264642", "R-BTA-888590", "R-RNO-199992", "R-GGA-6798695", "R-MMU-264642", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-DME-181430", "R-MMU-9013406", "R-HSA-1445148", "R-RNO-264642", "R-HSA-9013026", "R-HSA-1236974", "R-MMU-6798695", "R-HSA-5250971", "R-HSA-5250992", "R-RNO-181429", "R-HSA-212676", "R-RNO-6798695", "R-HSA-449836", "R-BTA-210500", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-1236974", "R-HSA-199992", "R-DME-264642", "R-HSA-9013423", "R-DME-888590", "R-DME-449836", "R-HSA-181429", "R-BTA-212676", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013406", "R-DME-181429", "R-GGA-212676", "R-DME-199992", "R-GGA-449836", "R-BTA-449836", "R-BTA-264642", "R-GGA-264642", "R-MMU-212676", "R-DME-6798695", "R-RNO-210500", "R-MMU-888590", "R-RNO-181430", "R-MMU-210500", "R-HSA-5250968", "R-MMU-181429", "R-DME-212676", "R-RNO-9013423", "R-GGA-888590", "R-HSA-888590", "R-MMU-9013026", "R-MMU-1236974", "R-BTA-181429", "R-HSA-9013406", "R-MMU-9013149", "R-RNO-888590", "R-RNO-449836", "R-DME-9013423", "R-HSA-422356"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-449836:r:Other interleukin signaling", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-GGA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-199992:r:trans-Golgi Network Vesicle Budding", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5250971:r:Toxicity of botulinum toxin type C (botC)", "R-HSA-5250992:r:Toxicity of botulinum toxin type E (botE)", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-449836:r:Other interleukin signaling", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1236974:r:ER-Phagosome pathway", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-449836:r:Other interleukin signaling", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-GGA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-199992:r:trans-Golgi Network Vesicle Budding", "R-GGA-449836:r:Other interleukin signaling", "R-BTA-449836:r:Other interleukin signaling", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-GGA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-5250968:r:Toxicity of botulinum toxin type A (botA)", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-GGA-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-1236974:r:ER-Phagosome pathway", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-449836:r:Other interleukin signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR000930": {"description": "Peptidase S3, togavirin", "go_ids": ["GO:0004252", "GO:0006508"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_S3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000932": {"description": "Photosystem antenna protein-like", "go_ids": ["GO:0009521", "GO:0009767", "GO:0016020", "GO:0016168", "GO:0019684"], "go_terms": ["GO:0009521:photosystem:C", "GO:0009767:photosynthetic electron transport chain:P", "GO:0016020:membrane:C", "GO:0016168:chlorophyll binding:F", "GO:0019684:photosynthesis, light reaction:P"], "name": "PS_antenna-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000933": {"description": "Glycoside hydrolase, family 29", "go_ids": ["GO:0004560", "GO:0005975"], "go_terms": ["GO:0004560:alpha-L-fucosidase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_29", "pathway_ids": ["PWY-6807", "R-DDI-6798695", "R-HSA-6798695", "R-DME-381426", "R-DDI-975578", "R-DME-8957275", "R-HSA-975578", "R-DME-6798695", "R-CEL-6798695", "R-BTA-6798695", "R-BTA-975578", "R-MMU-8957275", "R-CEL-975578", "R-RNO-381426", "R-DME-975578", "R-RNO-8957275", "R-MMU-381426", "R-CEL-381426", "R-CEL-8957275", "R-MMU-6798695", "R-RNO-975578", "R-HSA-8957275", "R-MMU-975578", "R-HSA-381426", "R-RNO-6798695"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DDI-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-CEL-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR000936": {"description": "Alphavirus E2 glycoprotein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Alpha_E2_glycop", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000937": {"description": "Icosahedral viral capsid protein, S domain", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Capsid_prot_S-dom_vir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000938": {"description": "CAP Gly-rich domain", "go_ids": [], "go_terms": [], "name": "CAP-Gly_domain", "pathway_ids": ["R-HSA-9842640", "R-SSC-3371497", "R-HSA-168638", "R-BTA-5689880", "R-BTA-5357786", "R-MMU-2467813", "R-HSA-5689880", "R-HSA-380284", "R-RNO-5357905", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-DDI-5626467", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5689880", "R-HSA-6811434", "R-SSC-2132295", "R-RNO-380284", "R-SSC-2565942", "R-MMU-5620912", "R-HSA-389977", "R-SSC-8854518", "R-MMU-141444", "R-SSC-380259", "R-MMU-380259", "R-MMU-380270", "R-HSA-141444", "R-HSA-9648025", "R-RNO-5663220", "R-HSA-5357786", "R-RNO-5689880", "R-MMU-6811436", "R-SSC-380284", "R-RNO-6811436", "R-SSC-6807878", "R-MMU-5357905", "R-RNO-936440", "R-MMU-8854518", "R-RNO-168638", "R-RNO-2467813", "R-RNO-380270", "R-MMU-3371497", "R-MMU-5663220", "R-RNO-141444", "R-SSC-380270", "R-HSA-2132295", "R-HSA-2467813", "R-HSA-5626467", "R-BTA-5357956", "R-RNO-2500257", "R-RNO-3371497", "R-HSA-936440", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-MMU-5357956", "R-HSA-2565942", "R-HSA-9725370", "R-HSA-5357905", "R-RNO-2565942", "R-BTA-936440", "R-HSA-68877", "R-MMU-2132295", "R-MMU-168638", "R-HSA-5620912", "R-BTA-168638", "R-MMU-9648025", "R-HSA-6811436", "R-MMU-2500257", "R-HSA-381038", "R-RNO-2132295", "R-MMU-5357786", "R-HSA-2500257", "R-MMU-5626467", "R-RNO-68877", "R-RNO-8854518", "R-RNO-6807878", "R-RNO-5626467", "R-HSA-6807878", "R-HSA-380270", "R-RNO-380259", "R-HSA-5357956", "R-HSA-983189", "R-RNO-5357956", "R-SSC-380320", "R-HSA-5663220", "R-MMU-936440", "R-RNO-9648025", "R-RNO-5357786", "R-HSA-380259", "R-BTA-5357905", "R-SSC-5620912"], "pathways": ["R-HSA-9842640:r:Signaling by LTK in cancer", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5357786:r:TNFR1-induced proapoptotic 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"R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-6811436:r:COPI-independent Golgi-to-ER 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"R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-168638:r:NOD1/2 Signaling 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biosynthesis (engineered)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-DRE-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-PFA-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-PFA-70171:r:Glycolysis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-DRE-70171:r:Glycolysis", "R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Family"}, "IPR000942": {"description": "Geminivirus AL2 coat protein, MSV type", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Gemini_AL2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000943": {"description": "RNA polymerase sigma-70", "go_ids": ["GO:0003700", "GO:0006352", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RNA_pol_sigma70", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000944": {"description": "Transcription regulator Rrf2", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_Rrf2", 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"R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation"], "type": "Domain"}, "IPR000953": {"description": "Chromo/chromo shadow domain", "go_ids": [], "go_terms": [], "name": "Chromo/chromo_shadow_dom", 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"R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-9843970:r:Regulation of 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"R-MMU-392451", "R-BTA-8853659", "R-MMU-5627117", "R-DDI-9841251", "R-MMU-2029485", "R-DDI-375165", "R-RNO-198323", "R-CEL-3928662", "R-RNO-165158", "R-MMU-442720", "R-MMU-165159", "R-CEL-1912408", "R-DDI-8948751", "R-SCE-442720", "R-CEL-389513", "R-HSA-199920", "R-DME-450520", "R-CEL-5627117", "R-RNO-2173791", "R-HSA-6811558", "R-RNO-1433557", "R-RNO-8963896", "R-DRE-209543", "R-DDI-9856530", "R-DME-1250196", "R-MMU-450604", "R-MMU-76005", "R-DDI-5625740", "R-MMU-8854518", "R-DME-76005", "R-DME-5607764", "R-HSA-1257604", "R-DME-2871837", "R-HSA-9013407", "R-SPO-6798695", "R-MMU-2179392", "R-DME-416993", "R-RNO-114516", "R-SPO-163615", "R-MMU-9856530", "R-DME-9634638", "R-MMU-9648002", "R-BTA-416993", "R-RNO-8876198", "R-DDI-2871837", "R-CEL-416476", "R-XTR-5668599", "R-DDI-76005", "R-HSA-2565942", "R-GGA-198753", "R-DME-5635838", "R-HSA-114508", "R-DDI-1169091", "R-DME-163615", "R-MMU-198693", "R-DDI-165181", "R-SCE-9634597", "R-MMU-5218921", "R-SPO-9856530", "R-HSA-180024", "R-GGA-1257604", "R-RNO-442720", "R-RNO-69202", "R-RNO-8856825", "R-MMU-2028269", "R-DDI-1257604", "R-MMU-5218920", "R-CEL-9614399", "R-SCE-114516", "R-RNO-5578775", "R-CEL-9634635", "R-SPO-4419969", "R-DRE-5625740", "R-GGA-6804757", "R-DRE-4419969", "R-DME-8876198", "R-DME-450385", "R-CEL-416572", "R-BTA-8856825", "R-DME-3000170", "R-RNO-1169091", "R-SCE-114508", "R-SPO-9837999", "R-MMU-3928662", "R-BTA-4419969", "R-HSA-165159", "R-SSC-2514859", "R-CEL-399997", "R-HSA-9013406", "R-HSA-202424", "R-RNO-2871837", "R-XTR-76005", "R-SCE-399997", "R-HSA-9607240", "R-PFA-8963896", "R-RNO-8948751", "R-DRE-1169091", "R-HSA-9013418", "R-HSA-9022692", "R-RNO-442742", "R-DRE-442742", "R-RNO-9607240", "R-CEL-114516", "R-RNO-5687128", "R-BTA-2514859", "R-MMU-9009391", "R-DME-9634635", "R-DDI-2179392", "R-MMU-380320", "R-MMU-3000170", "R-HSA-6804759", "R-RNO-9634597", "R-DME-390150", "R-XTR-114516", "R-MMU-211163", "R-BTA-2565942", "R-RNO-6811558", "R-CEL-1257604", "R-HSA-199418", "R-MMU-2465910", "R-RNO-450385", "R-CEL-165159", "R-DME-164378", "R-MMU-1489509", "R-HSA-5610783", "R-BTA-9634597", "R-SPO-9634635", "R-HSA-114604", "R-DME-1433559", "R-DME-9013149", "R-HSA-198753", "R-DME-198753", "R-DME-69202", "R-CEL-450604", "R-RNO-9013407", "R-HSA-983231", "R-PFA-5610787", "R-MMU-380270", "R-MMU-2559582", "R-RNO-180024", "R-MMU-432040", "R-HSA-9634600", "R-DDI-392451", "R-DME-9648002", "R-MMU-69656", "R-DRE-9755511", "R-HSA-1433559", "R-RNO-881907", "R-MMU-9841251", "R-MMU-1912408", "R-DME-1257604", "R-HSA-418597", "R-DME-110523", "R-HSA-8986944", "R-HSA-9031628", "R-MMU-5687128", "R-HSA-9648002", "R-CEL-199418", "R-CEL-165158", "R-RNO-6798695", "R-MMU-9837999", "R-SCE-2179392", "R-HSA-1474151", "R-DDI-199418", "R-HSA-2672351", "R-HSA-9634635", "R-MMU-380284", "R-DME-5625740", "R-CEL-389357", "R-CEL-111933", "R-MMU-165158", "R-SPO-164378", "R-HSA-9837999", "R-MMU-6804759", "R-MMU-111465", "R-DME-389513", "R-BTA-512988", "R-DRE-114516", "R-DDI-9837999", "R-HSA-5610780", "R-HSA-416993", "R-PFA-9837999", "R-SPO-114508", "R-SPO-1169091", "R-DME-9013422", "R-DME-203615", "R-SCE-9013106", "R-RNO-380259", "R-SCE-5218921", "R-HSA-877300", "R-RNO-3769402", "R-HSA-9856530", "R-CEL-9009391", "R-MMU-9013149", "R-RNO-3000170", "R-MMU-373752", "R-DME-9856530", "R-DDI-2028269", "R-HSA-9013422", "R-DME-375165", "R-DME-5621575", "R-SCE-2029485", "R-DME-451806", "R-RNO-5635838", "R-HSA-380284", "R-RNO-9013149", "R-HSA-2179392", "R-CEL-198753", "R-DRE-5218921", "R-HSA-8854518", "R-HSA-3928662", "R-MMU-9013422", "R-RNO-2029485", "R-SPO-881907", "R-RNO-5625740", "R-RNO-2179392", "R-DDI-2559582", "R-MMU-5628897", "R-BTA-392517", "R-DME-6804758", "R-BTA-9013418", "R-SCE-5610787", "R-PFA-9856530", "R-DRE-9013106", "R-MMU-420029", "R-DME-8980692", "R-HSA-2514859", "R-MMU-8853659", "R-CEL-76005", "R-MMU-450520", "R-HSA-6785807", "R-CEL-202424", "R-DME-354192", "R-DME-9755511", "R-MMU-9634635", "R-RNO-163615", "R-PFA-163615", "R-DME-110478", "R-DME-165158", "R-HSA-2465910", "R-MMU-2871837", "R-RNO-1358803", "R-SCE-203615", "R-DME-5610785", "R-RNO-4419969", "R-SPO-8948751", "R-DME-5628897", "R-RNO-4420097", "R-HSA-114516", "R-RNO-418555", "R-SPO-442720", "R-DME-1169091", "R-HSA-3769402", "R-CEL-8849469", "R-MMU-8856825", "R-MMU-422356", "R-RNO-111933", "R-MMU-199920", "R-DDI-198323", "R-DRE-444257", "R-BTA-114516", "R-HSA-2559582", "R-HSA-399997", "R-HSA-5628897", "R-CEL-9013149", "R-HSA-198323", "R-SCE-9634635", "R-MMU-5610785", "R-RNO-5625886", "R-DDI-389513", "R-RNO-373752", "R-DRE-2514859", "R-RNO-9648002", "R-HSA-211163", "R-HSA-9679191", "R-SCE-432040", "R-HSA-1433557", "R-RNO-9837999", "R-MMU-877300", "R-DDI-165158", "R-DME-9013418", "R-SPO-203615", "R-DME-9614399", "R-BTA-5218921", "R-BTA-8854518", "R-MMU-9013026", "R-RNO-5610785", "R-DDI-389357", "R-MMU-4419969", "R-RNO-1250196", "R-RNO-198753", "R-BTA-5610787", "R-SCE-198753", "R-RNO-9604323", "R-PFA-164378", "R-HSA-5627117", "R-CEL-211163", "R-RNO-9031628", "R-DDI-180024", "R-DDI-114516", "R-BTA-5625886", "R-MMU-6811558", "R-CEL-450385", "R-HSA-420029", "R-SCE-9841251", "R-DME-390178", "R-MMU-8948751", "R-DME-8948751", "R-RNO-5218920", "R-HSA-203615", "R-SCE-198323", "R-BTA-4420097", "R-CEL-9607240", "R-BTA-1169091", "R-DDI-2029485", "R-DME-2029485", "R-RNO-164378", "R-DME-432040"], "pathways": ["R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-GGA-375165:r:NCAM signaling for neurite out-growth", "R-MMU-392517:r:Rap1 signalling", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SPO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SPO-5610787:r:Hedgehog 'off' state", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-164378:r:PKA activation in glucagon signalling", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9696264:r:RND3 GTPase cycle", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-354192:r:Integrin signaling", "R-HSA-392517:r:Rap1 signalling", "R-RNO-9634638:r:Estrogen-dependent 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"R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-8853659:r:RET signaling", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-DDI-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-375165:r:NCAM signaling for neurite out-growth", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-RNO-165158:r:Activation of AKT2", "R-MMU-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-165159:r:MTOR signalling", "R-CEL-1912408:r:Pre-NOTCH Transcription and Translation", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-SCE-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-HSA-199920:r:CREB phosphorylation", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-RNO-2173791:r:TGF-beta 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activation", "R-MMU-198693:r:AKT phosphorylates targets in the nucleus", "R-DDI-165181:r:Inhibition of TSC complex formation by PKB", "R-SCE-9634597:r:GPER1 signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-180024:r:DARPP-32 events", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-RNO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-2028269:r:Signaling by Hippo", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9614399:r:Regulation of localization of FOXO transcription factors", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-RNO-5578775:r:Ion homeostasis", "R-CEL-9634635:r:Estrogen-stimulated signaling 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"R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-XTR-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SCE-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9607240:r:FLT3 Signaling", "R-PFA-8963896:r:HDL assembly", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-RNO-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-DRE-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-RNO-9607240:r:FLT3 Signaling", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-9009391:r:Extra-nuclear estrogen 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metabolism", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DME-9648002:r:RAS processing", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1433559:r:Regulation of KIT signaling", "R-RNO-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-1912408:r:Pre-NOTCH Transcription and Translation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-HSA-418597:r:G alpha (z) signalling events", "R-DME-110523:r:TOR signaling pathway", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-9031628:r:NGF-stimulated transcription", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9648002:r:RAS processing", "R-CEL-199418:r:Negative regulation of the PI3K/AKT network", "R-CEL-165158:r:Activation of AKT2", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SCE-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-111933:r:Calmodulin induced events", "R-MMU-165158:r:Activation of AKT2", "R-SPO-164378:r:PKA activation in glucagon signalling", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-DME-389513:r:Co-inhibition by CTLA4", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DRE-114516:r:Disinhibition of SNARE formation", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-PFA-9837999:r:Mitochondrial protein degradation", "R-SPO-114508:r:Effects of PIP2 hydrolysis", "R-SPO-1169091:r:Activation of NF-kappaB in B cells", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-DME-203615:r:eNOS activation", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-877300:r:Interferon gamma signaling", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by 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Transactivation by Gastrin", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-392517:r:Rap1 signalling", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-SCE-5610787:r:Hedgehog 'off' state", "R-PFA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DRE-9013106:r:RHOC GTPase cycle", "R-MMU-420029:r:Tight junction interactions", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-8853659:r:RET signaling", "R-CEL-76005:r:Response to elevated platelet cytosolic Ca2+", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-202424:r:Downstream TCR signaling", "R-DME-354192:r:Integrin signaling", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-RNO-163615:r:PKA activation", "R-PFA-163615:r:PKA activation", "R-DME-110478:r:Insulin signaling pathway", "R-DME-165158:r:Activation of AKT2", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-SCE-203615:r:eNOS activation", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-SPO-8948751:r:Regulation of PTEN stability and activity", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-RNO-418555:r:G alpha (s) signalling events", "R-SPO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-422356:r:Regulation of insulin secretion", "R-RNO-111933:r:Calmodulin induced events", "R-MMU-199920:r:CREB phosphorylation", "R-DDI-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-444257:r:RSK activation", "R-BTA-114516:r:Disinhibition of SNARE formation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-SCE-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-RNO-373752:r:Netrin-1 signaling", "R-DRE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-9648002:r:RAS processing", "R-HSA-211163:r:AKT-mediated inactivation of FOXO1A", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SCE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-877300:r:Interferon gamma signaling", "R-DDI-165158:r:Activation of AKT2", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-SPO-203615:r:eNOS activation", "R-DME-9614399:r:Regulation of localization of FOXO transcription factors", "R-BTA-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-198753:r:ERK/MAPK targets", "R-BTA-5610787:r:Hedgehog 'off' state", "R-SCE-198753:r:ERK/MAPK targets", "R-RNO-9604323:r:Negative regulation of NOTCH4 signaling", "R-PFA-164378:r:PKA activation in glucagon signalling", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-211163:r:AKT-mediated inactivation of FOXO1A", "R-RNO-9031628:r:NGF-stimulated transcription", "R-DDI-180024:r:DARPP-32 events", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-BTA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-420029:r:Tight junction interactions", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-390178:r:DS ligand not bound to FT receptor", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-203615:r:eNOS activation", "R-SCE-198323:r:AKT phosphorylates targets in the cytosol", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-9607240:r:FLT3 Signaling", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-DME-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-164378:r:PKA activation in glucagon signalling", "R-DME-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins"], "type": "Domain"}, "IPR000962": {"description": "Zinc finger, DksA/TraR C4-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_DskA_TraR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000965": {"description": "GPR domain", "go_ids": ["GO:0004350", "GO:0055129"], "go_terms": ["GO:0004350:glutamate-5-semialdehyde dehydrogenase activity:F", "GO:0055129:L-proline biosynthetic process:P"], "name": "GPR_dom", "pathway_ids": ["PWY-6922", "R-HSA-8964539", "R-MMU-9837999", "R-SPO-8964539", "R-CEL-9837999", "R-MMU-8964539", "R-SPO-9837999", "R-SCE-9837999", "R-CEL-8964539", "R-SCE-8964539", "R-HSA-9837999"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-8964539:r:Glutamate and glutamine metabolism", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-HSA-9837999:r:Mitochondrial protein degradation"], "type": "Domain"}, "IPR000966": {"description": "Metallothionein, family 5, Diptera", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Metalthion_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000967": {"description": "Zinc finger, NF-X1-type", "go_ids": ["GO:0005634", "GO:0008270"], "go_terms": ["GO:0005634:nucleus:C", "GO:0008270:zinc ion binding:F"], "name": "Znf_NFX1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR000968": {"description": "Influenza nuclear export protein NS2", "go_ids": ["GO:0039675"], "go_terms": ["GO:0039675:exit of virus from host cell nucleus through nuclear pore:P"], "name": "Flu_NS2", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168288", "R-HSA-168275", "R-HSA-168298", "R-HSA-168330", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168298:r:Release", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Family"}, "IPR000971": {"description": "Globin", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "Globin", "pathway_ids": ["R-HSA-6798695", "R-GGA-9707564", "R-RNO-1237044", "R-MMU-9707564", "R-RNO-1247673", "R-HSA-1247673", "R-BTA-2168880", "R-HSA-2168880", "R-GGA-1247673", "R-BTA-6798695", "R-XTR-2168880", "R-MMU-203615", "R-HSA-1237044", "R-BTA-1247673", "R-GGA-1237044", "R-HSA-203615", "R-HSA-8981607", "R-XTR-1237044", "R-MMU-9707616", "R-DRE-6798695", "R-HSA-9707564", "R-RNO-9707616", "R-HSA-9615710", "R-GGA-9707616", "R-MMU-2168880", "R-MMU-1237044", "R-DRE-8981607", "R-MMU-1247673", "R-RNO-2168880", "R-HSA-983231", "R-GGA-2168880", "R-DRE-203615", "R-RNO-9707564", "R-HSA-9707616", "R-BTA-9707616", "R-XTR-6798695", "R-GGA-6798695", "R-XTR-9707616", "R-RNO-203615", "R-MMU-8981607", "R-RNO-8981607", "R-BTA-8981607", "R-XTR-9707564", "R-XTR-1247673", "R-HSA-9927020", "R-SSC-8981607", "R-HSA-9613829", "R-BTA-1237044", "R-RNO-6798695", "R-GGA-8981607", "R-BTA-9707564"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-2168880:r:Scavenging of heme from plasma", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-GGA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-6798695:r:Neutrophil degranulation", "R-XTR-2168880:r:Scavenging of heme from plasma", "R-MMU-203615:r:eNOS activation", "R-HSA-1237044:r:Erythrocytes take up carbon 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plasma", "R-DRE-203615:r:eNOS activation", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707616:r:Heme signaling", "R-BTA-9707616:r:Heme signaling", "R-XTR-6798695:r:Neutrophil degranulation", "R-GGA-6798695:r:Neutrophil degranulation", "R-XTR-9707616:r:Heme signaling", "R-RNO-203615:r:eNOS activation", "R-MMU-8981607:r:Intracellular oxygen transport", "R-RNO-8981607:r:Intracellular oxygen transport", "R-BTA-8981607:r:Intracellular oxygen transport", "R-XTR-9707564:r:Cytoprotection by HMOX1", "R-XTR-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-9927020:r:Heme assimilation", "R-SSC-8981607:r:Intracellular oxygen transport", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-6798695:r:Neutrophil degranulation", "R-GGA-8981607:r:Intracellular oxygen transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR000975": {"description": "Interleukin-1 family", "go_ids": ["GO:0005576", "GO:0006955", "GO:0006954", "GO:0005125"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006955:immune response:P", "GO:0006954:inflammatory response:P", "GO:0005125:cytokine activity:F"], "name": "IL-1_fam", "pathway_ids": ["R-HSA-9020702", "R-SSC-9012546", "R-MMU-9960525", "R-RNO-9020702", "R-BTA-448706", "R-HSA-9960525", "R-MMU-9012546", "R-HSA-5620971", "R-MMU-9020702", "R-BTA-9960525", "R-HSA-2559582", "R-HSA-9960519", "R-RNO-448706", "R-SSC-5620971", "R-BTA-9960519", "R-HSA-448706", "R-HSA-5660668", "R-RNO-5620971", "R-BTA-5620971", "R-MMU-9960519", "R-BTA-9012546", "R-MMU-9014826", "R-HSA-9007892", "R-SSC-448706", "R-SSC-9020702", "R-HSA-6783783", "R-MMU-5660668", "R-SSC-9960525", "R-MMU-9007892", "R-HSA-9660826", "R-RNO-5660668", "R-HSA-6785807", "R-RNO-9012546", "R-SSC-9960519", "R-HSA-9008059", "R-HSA-9014826", "R-MMU-448706", "R-BTA-9020702", "R-HSA-9012546", "R-MMU-5620971"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-SSC-9012546:r:Interleukin-18 signaling", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-RNO-9020702:r:Interleukin-1 signaling", "R-BTA-448706:r:Interleukin-1 processing", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-MMU-9012546:r:Interleukin-18 signaling", "R-HSA-5620971:r:Pyroptosis", "R-MMU-9020702:r:Interleukin-1 signaling", "R-BTA-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9960519:r:CASP4-mediated substrate cleavage", "R-RNO-448706:r:Interleukin-1 processing", "R-SSC-5620971:r:Pyroptosis", "R-BTA-9960519:r:CASP4-mediated substrate cleavage", "R-HSA-448706:r:Interleukin-1 processing", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-RNO-5620971:r:Pyroptosis", "R-BTA-5620971:r:Pyroptosis", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-BTA-9012546:r:Interleukin-18 signaling", "R-MMU-9014826:r:Interleukin-36 pathway", "R-HSA-9007892:r:Interleukin-38 signaling", 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"R-GGA-5654706", "R-MMU-5663213", "R-MMU-456926", "R-MMU-9013420", "R-HSA-8853659", "R-RNO-983231", "R-DME-1295596", "R-DME-209209", "R-MMU-5673001", "R-HSA-2586552", "R-HSA-9701898", "R-MMU-167044", "R-HSA-9026527", "R-RNO-5673000", "R-RNO-5654732", "R-HSA-182971", "R-HSA-2424491", "R-DRE-912694", "R-HSA-8983432", "R-XTR-5654699", "R-SSC-9027284", "R-HSA-5637810", "R-GGA-389948", "R-RNO-9696264", "R-HSA-445144", "R-BTA-8851805", "R-CEL-8856825", "R-MMU-9860927", "R-RNO-8851907", "R-HSA-8857538", "R-MMU-430116", "R-MMU-8980692", "R-RNO-1169408", "R-BTA-375165", "R-HSA-2029485", "R-DME-1433557", "R-HSA-9013423", "R-HSA-8851907", "R-BTA-912526", "R-CEL-354192", "R-DDI-8985947", "R-MMU-512988", "R-DME-416476", "R-HSA-1250196", "R-DME-210671", "R-SSC-2029481", "R-MMU-3928664", "R-BTA-9705462", "R-MMU-437239", "R-MMU-391160", "R-MMU-9028731", "R-DME-8983432", "R-BTA-3928664", "R-RNO-1227986", "R-MMU-1660499", "R-GGA-5654712", "R-DRE-8874081", "R-HSA-9909649", "R-HSA-912526", "R-HSA-111465", "R-HSA-8875656", "R-DME-5654706", "R-RNO-6783783", "R-DRE-399954", "R-XTR-1257604", "R-MMU-5607764", "R-BTA-9013424", "R-DME-69231", "R-RNO-8866376", "R-MMU-9020933", "R-SSC-9732724", "R-RNO-9927353", "R-HSA-8875360", "R-HSA-8964315", "R-HSA-112382", "R-HSA-5654688", "R-CEL-373753", "R-BTA-983168", "R-MMU-389359", "R-MMU-9607240", "R-RNO-5654726", "R-RNO-5654710", "R-CEL-354194", "R-HSA-430116", "R-RNO-5654704", "R-CEL-912631", "R-SSC-399954", "R-RNO-9020956", "R-CEL-416482", "R-BTA-9035034", "R-HSA-4420097", "R-MMU-389356", "R-MMU-9833482", "R-DME-1660499", "R-CEL-1433559", "R-RNO-202424", "R-HSA-177929", "R-XTR-180336", "R-GGA-180292", "R-RNO-201556", "R-BTA-9013407", "R-HSA-9665686", "R-RNO-9020933", "R-SSC-8984722", "R-HSA-8847993", "R-DME-9020933", "R-SSC-399955", "R-BTA-912631", "R-MMU-674695", "R-XTR-5654720", "R-MMU-8875555", "R-DME-5654710", "R-BTA-389948", "R-RNO-389513", "R-HSA-5654720", "R-BTA-114604", "R-HSA-418890", "R-HSA-198933", "R-HSA-8948751", "R-RNO-8875555", "R-MMU-5654688", "R-MMU-399956", "R-BTA-9013106", "R-MMU-375165", "R-BTA-9766229", "R-RNO-430116", "R-DRE-9705462", "R-DRE-110056", "R-HSA-9032759", "R-BTA-399954", "R-HSA-6802946", "R-BTA-2871796", "R-XTR-5654710", "R-BTA-1059683", "R-DME-8856828", "R-RNO-9013106", "R-SSC-9020958", "R-MMU-5654228", "R-MMU-5654719", "R-DME-9020956", "R-SSC-399956", "R-MMU-202433", "R-SSC-9027276", "R-HSA-390471", "R-MMU-8849469", "R-DRE-9020958", "R-DME-9008059", "R-MMU-3928663", "R-MMU-9006335", "R-CEL-180336", "R-DDI-6783783", "R-MMU-418592", "R-BTA-9013408", "R-DRE-8853659", "R-RNO-5218921", "R-SSC-9701898", "R-HSA-9705462", "R-DME-209228", "R-GGA-512988", "R-HSA-2892247", "R-DME-201556", "R-RNO-186763", "R-MMU-9008059", "R-MMU-8857538", "R-HSA-9696273", "R-DRE-3928663", "R-CEL-5654704", "R-RNO-9013026", "R-XTR-6807004", "R-MMU-8849468", "R-RNO-8934903", "R-HSA-9942503", "R-MMU-3928665", "R-HSA-2871796", "R-RNO-9020591", "R-CEL-8941858", "R-HSA-198745", "R-XTR-5654688", "R-MMU-5685938", "R-HSA-5654695", "R-CEL-9013407", "R-SSC-9833482", "R-BTA-6811558", "R-XTR-5654719", "R-BTA-210990", "R-SSC-912631", "R-RNO-375165", "R-HSA-8875513", "R-HSA-6802955", "R-DME-5654727", "R-HSA-8984722", "R-GGA-1059683", "R-HSA-6802948", "R-HSA-452723", "R-GGA-877312", "R-CEL-74751", "R-CEL-674695", "R-HSA-5654700", "R-DRE-1227986", "R-CEL-1433557", "R-RNO-5654228", "R-MMU-179812", "R-MMU-1250196", "R-RNO-5654699", "R-HSA-9634597", "R-SSC-1266695", "R-MMU-5674135", "R-HSA-1059683", "R-HSA-202433", "R-DRE-877312", "R-SSC-912694", "R-HSA-6788467", "R-SSC-373753", "R-MMU-9034793", "R-RNO-8874081", "R-MMU-9020591", "R-HSA-8849474", "R-RNO-354192", "R-CEL-5654221", "R-HSA-9013148", "R-HSA-1963642", "R-RNO-5674135", "R-MMU-5621480", "R-GGA-912631", "R-RNO-399956", "R-BTA-5654699", "R-HSA-9696270", "R-HSA-167590", "R-SSC-4420097", "R-HSA-74749", "R-BTA-418885", "R-HSA-180336", "R-BTA-416482", "R-RNO-9013423", "R-MMU-1251985", "R-HSA-9009391", "R-DME-5654712", "R-DRE-1257604", "R-SSC-3928663", "R-CEL-179812", "R-HSA-3928665", "R-BTA-983695", "R-MMU-8851907", "R-MMU-9032759", "R-RNO-5654733", "R-HSA-9027277", "R-DME-186763", "R-HSA-428890", "R-MMU-9696273", "R-HSA-9725370", "R-DME-210688", "R-HSA-8849469", "R-MMU-416476", "R-HSA-6798695", "R-CEL-210993", "R-HSA-8875555", "R-MMU-1306955", "R-HSA-112411", "R-XTR-912631", "R-GGA-2029482", "R-MMU-4420097", "R-RNO-191650", "R-HSA-5654693", "R-RNO-198203", "R-DRE-69231", "R-HSA-399955", "R-DRE-877300", "R-BTA-112399", "R-HSA-5654221", "R-BTA-877312", "R-GGA-5654720", "R-CEL-9841922", "R-XTR-9028731", "R-SSC-186763", "R-CEL-5663213", "R-SSC-9032759", "R-HSA-9648895", "R-XTR-9027284", "R-MMU-202427", "R-SSC-8849474", "R-GGA-3928663", "R-MMU-8875513", "R-XTR-5654693", "R-HSA-9013407", "R-DRE-456926", "R-MMU-8863795", "R-MMU-2179392", "R-DDI-909733", "R-RNO-8876198", "R-GGA-4420097", "R-MMU-9013148", "R-SSC-877312", "R-XTR-9607240", "R-SSC-9706369", "R-CEL-3928663", "R-RNO-110056", "R-DME-428890", "R-SSC-8853659", "R-CEL-5654710", "R-DRE-1059683", "R-BTA-5654704", "R-MMU-9603381", "R-CEL-418592", "R-CEL-202433", "R-SSC-6811558", "R-HSA-8849471", "R-BTA-3928663", "R-DME-2424491", "R-DME-111465", "R-BTA-2871809", "R-HSA-9649948", "R-HSA-202430", "R-HSA-5621480", "R-HSA-5655302", "R-CEL-9013148", "R-RNO-389357", "R-MMU-9748787", "R-RNO-5654693", "R-CFA-1855204", "R-RNO-8853659", "R-MMU-166016", "R-CEL-177929", "R-HSA-8950505", "R-CEL-9833482", "R-MMU-5654700", "R-CEL-432142", "R-HSA-982772", "R-DRE-210990", "R-BTA-416476", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-5658442", "R-GGA-2029485", "R-HSA-1253288", "R-RNO-9028731", "R-HSA-5654704", "R-CEL-375165", "R-HSA-187577", "R-CEL-437239", "R-HSA-416476", "R-SSC-8951664", "R-DME-6811558", "R-CEL-418885", "R-HSA-1236382", "R-MMU-6788467", "R-HSA-5607764", "R-XTR-8875656", "R-HSA-9028731", "R-HSA-354192", "R-XTR-8851805", "R-GGA-2871796", "R-HSA-193648", "R-MMU-8854691", "R-CEL-1059683", "R-SSC-9020956", "R-MMU-8984722", "R-RNO-1963640", "R-HSA-354194", "R-GGA-432142", "R-RNO-389356", "R-CEL-2029482", "R-BTA-1433559", "R-BTA-2730905", "R-DME-9020591", "R-RNO-909733", "R-DME-9841922", "R-RNO-5654720", "R-MMU-2424491", "R-DRE-1295596", "R-MMU-8849472", "R-DME-4420097", "R-RNO-9008059"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-SSC-9766229:r:Degradation of CDH1", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8951664:r:Neddylation", "R-BTA-1227986:r:Signaling by ERBB2", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-CEL-6783783:r:Interleukin-10 signaling", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-XTR-1433557:r:Signaling by SCF-KIT", "R-CEL-182971:r:EGFR downregulation", "R-RNO-416476:r:G alpha (q) signalling events", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-XTR-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-9607240:r:FLT3 Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-MMU-9634597:r:GPER1 signaling", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-186763:r:Downstream signal transduction", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-389356:r:Co-stimulation by CD28", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-6783783:r:Interleukin-10 signaling", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-XTR-74749:r:Signal attenuation", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-1227986:r:Signaling by ERBB2", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DDI-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-GGA-877300:r:Interferon gamma signaling", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-MMU-74713:r:IRS activation", "R-RNO-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-8849474:r:PTK6 Activates STAT3", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9013424:r:RHOV GTPase cycle", "R-CEL-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-3928664:r:Ephrin signaling", "R-DME-74749:r:Signal attenuation", "R-XTR-5654732:r:Negative regulation of FGFR3 signaling", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-9696264:r:RND3 GTPase cycle", "R-RNO-389948:r:Co-inhibition by PD-1", "R-CEL-877312:r:Regulation of IFNG signaling", "R-BTA-210993:r:Tie2 Signaling", "R-XTR-5654689:r:PI-3K cascade:FGFR1", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CEL-6798695:r:Neutrophil degranulation", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8875791:r:MET activates STAT3", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-MMU-8951664:r:Neddylation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-8866376:r:Reelin signalling pathway", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-BTA-8853659:r:RET signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-BTA-1251985:r:Nuclear signaling by ERBB4", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-XTR-182971:r:EGFR downregulation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-SSC-74749:r:Signal attenuation", "R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-BTA-8854691:r:Interleukin-20 family signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-SSC-6783783:r:Interleukin-10 signaling", "R-DME-525793:r:Myogenesis", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-8854691:r:Interleukin-20 family signaling", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-MMU-198203:r:PI3K/AKT activation", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-BTA-201556:r:Signaling by ALK", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-8849473:r:PTK6 Expression", "R-XTR-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-1306955:r:GRB7 events in ERBB2 signaling", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-SSC-9008059:r:Interleukin-37 signaling", "R-GGA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SSC-2424491:r:DAP12 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-877312:r:Regulation of IFNG signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-74749:r:Signal attenuation", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-5673000:r:RAF activation", "R-CEL-8849470:r:PTK6 Regulates Cell Cycle", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-877300:r:Interferon gamma signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1266695:r:Interleukin-7 signaling", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9833482:r:PKR-mediated signaling", "R-DDI-8984722:r:Interleukin-35 Signalling", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-167021:r:PLC-gamma1 signalling", "R-RNO-9607240:r:FLT3 Signaling", "R-XTR-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-9634597:r:GPER1 signaling", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-DME-74751:r:Insulin receptor signalling cascade", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-DME-3928664:r:Ephrin signaling", "R-SSC-982772:r:Growth hormone receptor signaling", "R-CEL-9008059:r:Interleukin-37 signaling", "R-DME-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-GGA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-BTA-8983432:r:Interleukin-15 signaling", "R-GGA-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8875656:r:MET receptor recycling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8851805:r:MET activates RAS signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-RNO-8951664:r:Neddylation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-912631:r:Regulation of signaling by CBL", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-DME-112412:r:SOS-mediated signalling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9013420:r:RHOU GTPase cycle", "R-BTA-167044:r:Signalling to RAS", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-BTA-9607240:r:FLT3 Signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DDI-9008059:r:Interleukin-37 signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-BTA-373753:r:Nephrin family interactions", "R-GGA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-GGA-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-114604:r:GPVI-mediated activation cascade", "R-HSA-432142:r:Platelet sensitization by LDL", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DRE-191650:r:Regulation of gap junction activity", "R-XTR-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-GGA-8875656:r:MET receptor recycling", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-DME-1266695:r:Interleukin-7 signaling", "R-HSA-164944:r:Nef and signal transduction", "R-SSC-877300:r:Interferon gamma signaling", "R-BTA-877300:r:Interferon gamma signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-XTR-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-5621480:r:Dectin-2 family", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-GGA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-DDI-877312:r:Regulation of IFNG signaling", "R-BTA-8951664:r:Neddylation", "R-HSA-449836:r:Other interleukin signaling", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-3928664:r:Ephrin signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-XTR-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-SSC-1433559:r:Regulation of KIT signaling", "R-CEL-6807004:r:Negative regulation of MET activity", "R-XTR-186763:r:Downstream signal transduction", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-BTA-9020958:r:Interleukin-21 signaling", "R-DDI-201556:r:Signaling by ALK", "R-DME-8854691:r:Interleukin-20 family signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-877300:r:Interferon gamma signaling", "R-GGA-1433559:r:Regulation of KIT signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418594:r:G alpha (i) signalling events", "R-GGA-170984:r:ARMS-mediated activation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-XTR-8853659:r:RET signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-XTR-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-198203:r:PI3K/AKT activation", "R-SSC-9607240:r:FLT3 Signaling", "R-XTR-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-SSC-210990:r:PECAM1 interactions", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-5673000:r:RAF activation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-5673000:r:RAF activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-1059683:r:Interleukin-6 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-XTR-8865999:r:MET activates PTPN11", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-186763:r:Downstream signal transduction", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-CFA-912526:r:Interleukin receptor SHC signaling", "R-SSC-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-9766229:r:Degradation of CDH1", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-DME-209405:r:JAK/STAT pathway", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-8983432:r:Interleukin-15 signaling", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DME-9013148:r:CDC42 GTPase cycle", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-DDI-8854691:r:Interleukin-20 family signaling", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-9020558:r:Interleukin-2 signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DRE-5621480:r:Dectin-2 family", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-BTA-9634597:r:GPER1 signaling", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-GGA-5654689:r:PI-3K cascade:FGFR1", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-RNO-2029481:r:FCGR activation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-XTR-5654704:r:SHC-mediated cascade:FGFR3", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-BTA-2424491:r:DAP12 signaling", "R-SSC-1227986:r:Signaling by ERBB2", "R-RNO-9035034:r:RHOF GTPase cycle", "R-GGA-8951664:r:Neddylation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-CEL-8983432:r:Interleukin-15 signaling", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-BTA-9696270:r:RND2 GTPase cycle", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-167044:r:Signalling to RAS", "R-BTA-1250196:r:SHC1 events in ERBB2 signaling", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-SSC-74713:r:IRS activation", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-8985947:r:Interleukin-9 signaling", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-DRE-6783783:r:Interleukin-10 signaling", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-112399:r:IRS-mediated signalling", "R-XTR-179812:r:GRB2 events in EGFR signaling", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-GGA-109704:r:PI3K Cascade", "R-HSA-6783783:r:Interleukin-10 signaling", "R-XTR-2424491:r:DAP12 signaling", "R-GGA-8854691:r:Interleukin-20 family signaling", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-BTA-74751:r:Insulin receptor signalling cascade", "R-XTR-9842663:r:Signaling by LTK", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-GGA-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-9696273:r:RND1 GTPase cycle", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DRE-177929:r:Signaling by EGFR", "R-HSA-9620244:r:Long-term potentiation", "R-GGA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-CEL-9020933:r:Interleukin-23 signaling", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-XTR-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-201556:r:Signaling by ALK", "R-XTR-167044:r:Signalling to RAS", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-69231:r:Cyclin D associated events in G1", "R-XTR-2871796:r:FCERI mediated MAPK activation", "R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-389356:r:Co-stimulation by CD28", "R-RNO-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-8984722:r:Interleukin-35 Signalling", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-171007:r:p38MAPK events", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-GGA-210990:r:PECAM1 interactions", "R-DME-909733:r:Interferon alpha/beta signaling", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-180292:r:GAB1 signalosome", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-112399:r:IRS-mediated signalling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-SSC-8875791:r:MET activates STAT3", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-373753:r:Nephrin family interactions", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-912631:r:Regulation of signaling by CBL", "R-DME-9020558:r:Interleukin-2 signaling", "R-XTR-112412:r:SOS-mediated signalling", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-GGA-354192:r:Integrin signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-GGA-5654695:r:PI-3K cascade:FGFR2", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-210693:r:STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-8866376:r:Reelin signalling pathway", "R-BTA-9674555:r:Signaling by CSF3 (G-CSF)", "R-DDI-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-186763:r:Downstream signal transduction", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-74713:r:IRS activation", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9008059:r:Interleukin-37 signaling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-XTR-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-CEL-877300:r:Interferon gamma signaling", "R-CEL-9748787:r:Azathioprine ADME", "R-RNO-912694:r:Regulation of IFNA/IFNB signaling", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-RNO-177929:r:Signaling by EGFR", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-XTR-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-112399:r:IRS-mediated signalling", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9706369:r:Negative regulation of FLT3", "R-DDI-9833482:r:PKR-mediated signaling", "R-BTA-180292:r:GAB1 signalosome", "R-XTR-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1227986:r:Signaling by ERBB2", "R-GGA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-9833482:r:PKR-mediated signaling", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-DDI-9020591:r:Interleukin-12 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-1266695:r:Interleukin-7 signaling", "R-RNO-5621480:r:Dectin-2 family", "R-XTR-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-DDI-9020933:r:Interleukin-23 signaling", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-XTR-5654695:r:PI-3K cascade:FGFR2", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-GGA-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-8875513:r:MET interacts with TNS proteins", "R-BTA-9706369:r:Negative regulation of FLT3", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-XTR-74751:r:Insulin receptor signalling cascade", "R-HSA-373753:r:Nephrin family interactions", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-201556:r:Signaling by ALK", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-XTR-109704:r:PI3K Cascade", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-354192:r:Integrin signaling", "R-CEL-9020591:r:Interleukin-12 signaling", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-8853659:r:RET signaling", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-CEL-8849472:r:PTK6 Down-Regulation", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-XTR-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-109704:r:PI3K Cascade", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9842663:r:Signaling by LTK", "R-SSC-8985947:r:Interleukin-9 signaling", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DDI-877300:r:Interferon gamma signaling", "R-DME-9748787:r:Azathioprine ADME", "R-DDI-9020956:r:Interleukin-27 signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-525793:r:Myogenesis", "R-MMU-389948:r:Co-inhibition by PD-1", "R-DME-180292:r:GAB1 signalosome", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-9645135:r:STAT5 Activation", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-GGA-389356:r:Co-stimulation by CD28", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-DDI-1059683:r:Interleukin-6 signaling", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-CEL-8984722:r:Interleukin-35 Signalling", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-8866376:r:Reelin signalling pathway", "R-RNO-182971:r:EGFR downregulation", "R-DDI-8983432:r:Interleukin-15 signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-RNO-373753:r:Nephrin family interactions", "R-RNO-1433559:r:Regulation of KIT signaling", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-112412:r:SOS-mediated signalling", "R-XTR-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-SSC-389356:r:Co-stimulation by CD28", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-DME-8985947:r:Interleukin-9 signaling", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DRE-430116:r:GP1b-IX-V activation signalling", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-MMU-193648:r:NRAGE signals death through JNK", "R-XTR-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-8983432:r:Interleukin-15 signaling", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-182971:r:EGFR downregulation", "R-HSA-8985947:r:Interleukin-9 signaling", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-CEL-3249367:r:STAT6-mediated induction of chemokines", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-112412:r:SOS-mediated signalling", "R-XTR-1295596:r:Spry regulation of FGF signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-109704:r:PI3K Cascade", "R-GGA-210993:r:Tie2 Signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-BTA-109704:r:PI3K Cascade", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-201556:r:Signaling by ALK", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-74749:r:Signal attenuation", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-CEL-8851805:r:MET activates RAS signaling", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-GGA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-170984:r:ARMS-mediated activation", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-XTR-180292:r:GAB1 signalosome", "R-BTA-8985947:r:Interleukin-9 signaling", "R-BTA-430116:r:GP1b-IX-V activation signalling", "R-HSA-191650:r:Regulation of gap junction activity", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-XTR-210993:r:Tie2 Signaling", "R-MMU-191650:r:Regulation of gap junction activity", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-167044:r:Signalling to RAS", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-CEL-9020956:r:Interleukin-27 signaling", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-74713:r:IRS activation", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-CEL-8980692:r:RHOA GTPase cycle", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-SSC-909733:r:Interferon alpha/beta signaling", "R-DME-912631:r:Regulation of signaling by CBL", "R-HSA-2029481:r:FCGR activation", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-210993:r:Tie2 Signaling", "R-BTA-9013409:r:RHOJ GTPase cycle", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-170968:r:Frs2-mediated activation", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-8865999:r:MET activates PTPN11", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-RNO-9748787:r:Azathioprine ADME", "R-DME-5673000:r:RAF activation", "R-CEL-525793:r:Myogenesis", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-DDI-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-XTR-1963642:r:PI3K events in ERBB2 signaling", "R-CEL-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-354192:r:Integrin signaling", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-DRE-912631:r:Regulation of signaling by CBL", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-RNO-1059683:r:Interleukin-6 signaling", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-186763:r:Downstream signal transduction", "R-GGA-186763:r:Downstream signal transduction", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-8985947:r:Interleukin-9 signaling", "R-BTA-180336:r:SHC1 events in EGFR signaling", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-8849474:r:PTK6 Activates STAT3", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-8866376:r:Reelin signalling pathway", "R-BTA-5621480:r:Dectin-2 family", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-SSC-74751:r:Insulin receptor signalling cascade", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-GGA-8865999:r:MET activates PTPN11", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210993:r:Tie2 Signaling", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-GGA-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-DME-209209:r:Formation of the activated receptor complex", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-167044:r:Signalling to RAS", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-5673000:r:RAF activation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-182971:r:EGFR downregulation", "R-HSA-2424491:r:DAP12 signaling", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-XTR-5654699:r:SHC-mediated cascade:FGFR2", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-GGA-389948:r:Co-inhibition by PD-1", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-445144:r:Signal transduction by L1", "R-BTA-8851805:r:MET activates RAS signaling", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-BTA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-CEL-354192:r:Integrin signaling", "R-DDI-8985947:r:Interleukin-9 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-210671:r:Transcriptional repression by nuclear factors", "R-SSC-2029481:r:FCGR activation", "R-MMU-3928664:r:Ephrin signaling", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DME-8983432:r:Interleukin-15 signaling", "R-BTA-3928664:r:Ephrin signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-GGA-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-8874081:r:MET activates PTK2 signaling", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-8875656:r:MET receptor recycling", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-6783783:r:Interleukin-10 signaling", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-XTR-1257604:r:PIP3 activates AKT signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-9013424:r:RHOV GTPase cycle", "R-DME-69231:r:Cyclin D associated events in G1", "R-RNO-8866376:r:Reelin signalling pathway", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9927353:r:Co-inhibition by BTLA", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-373753:r:Nephrin family interactions", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-RNO-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-912631:r:Regulation of signaling by CBL", "R-SSC-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-9020956:r:Interleukin-27 signaling", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1433559:r:Regulation of KIT signaling", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-177929:r:Signaling by EGFR", "R-XTR-180336:r:SHC1 events in EGFR signaling", "R-GGA-180292:r:GAB1 signalosome", "R-RNO-201556:r:Signaling by ALK", "R-BTA-9013407:r:RHOH GTPase cycle", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-DME-9020933:r:Interleukin-23 signaling", "R-SSC-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-BTA-912631:r:Regulation of signaling by CBL", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-5654720:r:PI-3K cascade:FGFR4", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-BTA-9766229:r:Degradation of CDH1", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-XTR-5654710:r:PI-3K cascade:FGFR3", "R-BTA-1059683:r:Interleukin-6 signaling", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-SSC-9020958:r:Interleukin-21 signaling", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-9020956:r:Interleukin-27 signaling", "R-SSC-399956:r:CRMPs in Sema3A signaling", "R-MMU-202433:r:Generation of second messenger molecules", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-DRE-9020958:r:Interleukin-21 signaling", "R-DME-9008059:r:Interleukin-37 signaling", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-DDI-6783783:r:Interleukin-10 signaling", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-9013408:r:RHOG GTPase cycle", "R-DRE-8853659:r:RET signaling", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-SSC-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-GGA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-DME-201556:r:Signaling by ALK", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-9008059:r:Interleukin-37 signaling", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-9013026:r:RHOB GTPase cycle", "R-XTR-6807004:r:Negative regulation of MET activity", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-RNO-9020591:r:Interleukin-12 signaling", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-198745:r:Signalling to STAT3", "R-XTR-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SSC-9833482:r:PKR-mediated signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-XTR-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-210990:r:PECAM1 interactions", "R-SSC-912631:r:Regulation of signaling by CBL", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-GGA-1059683:r:Interleukin-6 signaling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-GGA-877312:r:Regulation of IFNG signaling", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DRE-1227986:r:Signaling by ERBB2", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9634597:r:GPER1 signaling", "R-SSC-1266695:r:Interleukin-7 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-DRE-877312:r:Regulation of IFNG signaling", "R-SSC-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-373753:r:Nephrin family interactions", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-RNO-354192:r:Integrin signaling", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-MMU-5621480:r:Dectin-2 family", "R-GGA-912631:r:Regulation of signaling by CBL", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-BTA-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-74749:r:Signal attenuation", "R-BTA-418885:r:DCC mediated attractive signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-SSC-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-DME-186763:r:Downstream signal transduction", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-XTR-912631:r:Regulation of signaling by CBL", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-191650:r:Regulation of gap junction activity", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-DRE-69231:r:Cyclin D associated events in G1", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-877300:r:Interferon gamma signaling", "R-BTA-112399:r:IRS-mediated signalling", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-BTA-877312:r:Regulation of IFNG signaling", "R-GGA-5654720:r:PI-3K cascade:FGFR4", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-XTR-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-SSC-186763:r:Downstream signal transduction", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-XTR-9027284:r:Erythropoietin activates RAS", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-8849474:r:PTK6 Activates STAT3", "R-GGA-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-XTR-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-GGA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-SSC-877312:r:Regulation of IFNG signaling", "R-XTR-9607240:r:FLT3 Signaling", "R-SSC-9706369:r:Negative regulation of FLT3", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SSC-8853659:r:RET signaling", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-DRE-1059683:r:Interleukin-6 signaling", "R-BTA-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CEL-202433:r:Generation of second messenger molecules", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9748787:r:Azathioprine ADME", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-CFA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-177929:r:Signaling by EGFR", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CEL-9833482:r:PKR-mediated signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-432142:r:Platelet sensitization by LDL", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DRE-210990:r:PECAM1 interactions", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-GGA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-SSC-8951664:r:Neddylation", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-418885:r:DCC mediated attractive signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-8875656:r:MET receptor recycling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-354192:r:Integrin signaling", "R-XTR-8851805:r:MET activates RAS signaling", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-CEL-1059683:r:Interleukin-6 signaling", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-432142:r:Platelet sensitization by LDL", "R-RNO-389356:r:Co-stimulation by CD28", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-1433559:r:Regulation of KIT signaling", "R-BTA-2730905:r:Role of 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"R-HSA-388479", "R-HSA-1368108", "R-SSC-416476", "R-MMU-432040", "R-BTA-416476", "R-BTA-388479", "R-MMU-388479", "R-MMU-879518", "R-SSC-8856828", "R-HSA-432040", "R-DRE-388479", "R-HSA-8856825", "R-DRE-879518", "R-SSC-8856825", "R-RNO-8856828", "R-RNO-432040", "R-DRE-416476", "R-HSA-9036092", "R-RNO-416476", "R-DRE-432040", "R-MMU-418555", "R-HSA-5619099"], "pathways": ["R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-879518:r:Organic anion transport by SLCO transporters", "R-SSC-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-388479:r:Vasopressin-like receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-388479:r:Vasopressin-like receptors", "R-HSA-418555:r:G alpha (s) 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"R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR000989": {"description": "Replication protein", "go_ids": ["GO:0003677", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006260:DNA replication:P"], "name": "Rep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000990": {"description": "Innexin", "go_ids": [], "go_terms": [], "name": "Innexin", "pathway_ids": ["R-RNO-112303", "R-HSA-112303", "R-HSA-9856530", "R-HSA-9856532", "R-MMU-112303", "R-RNO-844456", "R-MMU-844456", "R-HSA-844456"], "pathways": ["R-RNO-112303:r:Electric Transmission Across Gap Junctions", "R-HSA-112303:r:Electric Transmission Across Gap Junctions", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-112303:r:Electric Transmission Across Gap Junctions", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Family"}, "IPR000992": {"description": "Stress-induced protein SRP1/TIP1", "go_ids": [], "go_terms": [], "name": "SRP1_TIP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR000994": {"description": "Peptidase M24", "go_ids": [], "go_terms": [], "name": "Pept_M24", "pathway_ids": ["R-HSA-6798695", "R-MMU-163125", "R-SPO-6798695", "R-SPO-674695", "R-HSA-167238", "R-SCE-163125", "R-DDI-163125", "R-DME-6796648", "R-SCE-6804756", "R-BTA-2514859", "R-MMU-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-HSA-112382", "R-DDI-674695", "R-HSA-167152", "R-MMU-2514859", "R-DDI-6796648", 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"R-MMU-110331:r:Cleavage of the damaged purine", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-DRE-5689901:r:Metalloprotease DUBs", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-3214815:r:HDACs deacetylate histones", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-SPO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5689901:r:Metalloprotease DUBs", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-3214815:r:HDACs deacetylate histones", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-MMU-5683826:r:Surfactant metabolism", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-GGA-418124:r:Telomere maintenance", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand"], "type": "Domain"}, "IPR001007": {"description": "VWFC domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "VWF_dom", "pathway_ids": ["R-HSA-186797", "R-HSA-2032785", "R-HSA-5083632", "R-MMU-163125", "R-HSA-8874081", "R-HSA-2243919", "R-HSA-5674135", "R-RNO-2022090", "R-HSA-6802952", "R-MMU-76009", "R-HSA-3000178", "R-HSA-8936459", "R-HSA-140837", "R-HSA-430116", "R-MMU-2122948", "R-RNO-9013149", "R-MMU-8957275", "R-MMU-2243919", "R-HSA-1650814", "R-MMU-3000171", "R-HSA-2979096", "R-MMU-3000178", "R-HSA-9649948", "R-HSA-9846298", "R-HSA-8948216", "R-MMU-381426", "R-HSA-5083625", "R-HSA-9672391", "R-GGA-8957275", "R-HSA-9926550", "R-HSA-9013507", "R-HSA-2691232", "R-HSA-5621480", "R-RNO-3000178", "R-HSA-6802955", "R-HSA-381426", "R-HSA-114604", "R-RNO-3000171", "R-HSA-9672393", "R-DME-2979096", "R-DME-9013149", "R-HSA-6802948", "R-RNO-1566977", "R-DRE-2979096", "R-GGA-201451", "R-RNO-8948216", "R-HSA-8951671", "R-HSA-3000171", "R-HSA-9845619", "R-MMU-140837", "R-RNO-9013507", "R-HSA-419037", "R-HSA-163125", "R-RNO-381426", "R-MMU-9013423", "R-HSA-75892", "R-HSA-9013149", "R-RNO-5173214", "R-HSA-2022090", "R-HSA-2660826", "R-MMU-5173214", "R-MMU-216083", "R-HSA-198933", "R-HSA-2644606", "R-HSA-372708", "R-MMU-186797", "R-MMU-354192", "R-HSA-8940973", "R-HSA-9656223", "R-MMU-419037", "R-MMU-114608", "R-DRE-9013423", "R-MMU-5674135", "R-RNO-216083", "R-HSA-8941856", "R-HSA-2122948", "R-HSA-9845620", "R-HSA-3000480", "R-MMU-8948216", "R-BTA-1442490", "R-HSA-977068", "R-MMU-913709", "R-MMU-430116", "R-HSA-201451", "R-BTA-3000178", "R-HSA-9845622", "R-HSA-9845621", "R-BTA-2022090", "R-RNO-8874081", "R-HSA-9013423", "R-HSA-114608", "R-HSA-9638630", "R-HSA-76009", "R-MMU-8874081", "R-MMU-372708", "R-HSA-9013700", "R-HSA-6802946", "R-RNO-8957275", "R-BTA-3000171", "R-BTA-186797", "R-MMU-9013507", "R-DRE-9013149", "R-RNO-419037", "R-MMU-201451", "R-MMU-977068", "R-RNO-201451", "R-DME-9013423", "R-GGA-381426", "R-HSA-1442490", "R-BTA-1650814", "R-HSA-354192", "R-HSA-9925563", "R-RNO-1650814", "R-HSA-2214320", "R-BTA-8874081", "R-BTA-1566977", "R-HSA-216083", "R-HSA-3000170", "R-MMU-1566977", "R-HSA-5083636", "R-HSA-5083635", "R-DME-6798695", "R-HSA-1566977", "R-RNO-186797", "R-HSA-2894862", "R-HSA-9662361", "R-HSA-428542", "R-HSA-354194", "R-MMU-354194", "R-RNO-1442490", "R-MMU-2022090", "R-RNO-9013423", "R-BTA-8948216", "R-DME-8941413", "R-DME-209968", "R-HSA-5173214", "R-MMU-1650814", "R-HSA-8957275", "R-HSA-9831926", "R-MMU-9013149", "R-BTA-216083", "R-MMU-1442490", "R-HSA-202733", "R-HSA-913709"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-8948216:r:Collagen chain trimerization", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-5621480:r:Dectin-2 family", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-DME-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-1566977:r:Fibronectin matrix formation", "R-DRE-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-GGA-201451:r:Signaling by BMP", "R-RNO-8948216:r:Collagen chain trimerization", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-354192:r:Integrin signaling", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-419037:r:NCAM1 interactions", "R-MMU-114608:r:Platelet degranulation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-MMU-8948216:r:Collagen chain trimerization", "R-BTA-1442490:r:Collagen degradation", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-201451:r:Signaling by BMP", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-BTA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-BTA-3000171:r:Non-integrin membrane-ECM interactions", "R-BTA-186797:r:Signaling by PDGF", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-419037:r:NCAM1 interactions", "R-MMU-201451:r:Signaling by BMP", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-RNO-201451:r:Signaling by BMP", "R-DME-9013423:r:RAC3 GTPase cycle", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-354192:r:Integrin signaling", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-2214320:r:Anchoring fibril formation", "R-BTA-8874081:r:MET activates PTK2 signaling", "R-BTA-1566977:r:Fibronectin matrix formation", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-1566977:r:Fibronectin matrix formation", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-1442490:r:Collagen degradation", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-BTA-8948216:r:Collagen chain trimerization", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-DME-209968:r:Thyroxine biosynthesis", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9831926:r:Nephron development", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-216083:r:Integrin cell surface interactions", "R-MMU-1442490:r:Collagen degradation", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Domain"}, "IPR001009": {"description": "Influenza RNA-dependent RNA polymerase subunit PA", "go_ids": ["GO:0039694", "GO:0003723"], "go_terms": ["GO:0039694:viral RNA genome replication:P", "GO:0003723:RNA binding:F"], "name": "PA/PA-X", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-192814", "R-HSA-192905", "R-HSA-168275", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Family"}, "IPR001010": {"description": "Thionin", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "Thionin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001011": {"description": "Acid phosphatase, class A, bacterial", "go_ids": ["GO:0003993", "GO:0030288"], "go_terms": ["GO:0003993:acid phosphatase activity:F", "GO:0030288:outer membrane-bounded periplasmic space:C"], "name": "Acid_Pase_classA_bac", "pathway_ids": ["PWY-6348"], "pathways": ["PWY-6348:t:phosphate acquisition"], "type": "Family"}, "IPR001012": {"description": "UBX domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "UBX_dom", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-GGA-9013407", "R-XTR-532668", "R-DDI-9755511", "R-HSA-8951664", "R-MMU-8980692", "R-RNO-9696270", "R-RNO-5693565", "R-SCE-6798695", "R-RNO-8980692", "R-BTA-6798695", "R-HSA-5693565", "R-MMU-9755511", "R-CEL-532668", "R-DRE-532668", "R-DDI-8951664", "R-MMU-5693565", "R-MMU-8951664", "R-CEL-9013407", "R-SCE-8980692", "R-MMU-532668", "R-HSA-9013407", "R-HSA-532668", "R-BTA-9013407", "R-MMU-9013407", "R-HSA-9696270", "R-RNO-9013407", "R-SCE-9755511", "R-HSA-9755511", "R-BTA-5693565", "R-RNO-9696273", "R-XTR-6798695", "R-SPO-9755511", "R-HSA-9696264", "R-SPO-8980692", "R-SCE-8951664", "R-XTR-8980692", "R-HSA-8980692", "R-RNO-532668", "R-HSA-1445148", "R-RNO-9696264", "R-BTA-8980692", "R-SPO-8951664", "R-MMU-6798695", "R-MMU-9696264", "R-MMU-9696270", "R-BTA-532668", "R-MMU-9696273", "R-RNO-6798695", "R-HSA-9696273"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-GGA-9013407:r:RHOH GTPase cycle", "R-XTR-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-8980692:r:RHOA GTPase cycle", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-8951664:r:Neddylation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-8951664:r:Neddylation", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-9696273:r:RND1 GTPase cycle", "R-XTR-6798695:r:Neutrophil degranulation", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9696264:r:RND3 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SCE-8951664:r:Neddylation", "R-XTR-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-9696264:r:RND3 GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-SPO-8951664:r:Neddylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR001015": {"description": "Ferrochelatase", "go_ids": ["GO:0004325", "GO:0006783"], "go_terms": ["GO:0004325:protoporphyrin ferrochelatase activity:F", "GO:0006783:heme biosynthetic process:P"], "name": "Ferrochelatase", "pathway_ids": ["R-DDI-9837999", "R-MMU-9837999", "R-DME-189451", "R-MMU-189451", "R-SPO-9837999", "R-BTA-9837999", "R-HSA-189451", "R-SCE-9837999", "R-DME-9837999", "R-GGA-421984", "R-DDI-189451", "R-HSA-9837999", "R-BTA-189451", "R-SCE-189451", "R-SPO-189451"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DME-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-189451:r:Heme biosynthesis", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-GGA-421984:r:Heme synthesis", "R-DDI-189451:r:Heme biosynthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis"], "type": "Family"}, "IPR001017": {"description": "Dehydrogenase, E1 component", "go_ids": ["GO:0016624"], "go_terms": ["GO:0016624:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor:F"], "name": "DH_E1", "pathway_ids": ["R-DDI-9859138", "R-MMU-9837999", "R-SSC-9861559", "R-SPO-9861559", "R-SPO-9853506", "R-HSA-9853506", "R-SSC-204174", "R-DDI-9858328", "R-HSA-9858328", "R-MMU-9861559", "R-CFA-9861559", "R-MMU-70895", "R-BTA-6783984", "R-BTA-9837999", "R-CEL-9861559", "R-DDI-6783984", "R-HSA-9912481", "R-SPO-6783984", "R-HSA-9837999", "R-CEL-9859138", "R-DRE-9858328", "R-HSA-5362517", "R-MMU-9853506", "R-CFA-9837999", "R-CFA-5362517", "R-HSA-9859138", "R-SSC-5362517", "R-RNO-9861559", "R-BTA-9853506", "R-DDI-9837999", "R-DME-9858328", "R-HSA-204174", "R-SPO-5362517", "R-CEL-9837999", "R-SCE-9853506", "R-RNO-204174", "R-CEL-6783984", "R-MMU-6783984", "R-HSA-9865125", "R-CEL-9853506", "R-SCE-6783984", "R-CEL-204174", "R-CEL-5362517", "R-HSA-70895", "R-HSA-9907570", "R-RNO-9837999", "R-CFA-204174", "R-RNO-9858328", "R-HSA-9861559", "R-RNO-9853506", "R-RNO-70895", "R-RNO-6783984", "R-DDI-9853506", "R-SSC-9853506", "R-MMU-204174", "R-SSC-6783984", "R-RNO-9859138", "R-CEL-9858328", "R-SCE-9861559", "R-MMU-9859138", "R-SPO-9837999", "R-SCE-9837999", "R-MMU-5362517", "R-HSA-6783984", "R-SSC-9837999", "R-MMU-9858328", "R-HSA-9865113", "R-HSA-9912529", "R-DDI-9861559", "R-SPO-204174", "R-RNO-5362517"], "pathways": ["R-DDI-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SSC-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SPO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-MMU-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-CFA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-BTA-6783984:r:Glycine degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-CEL-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-DDI-6783984:r:Glycine degradation", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-SPO-6783984:r:Glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-CEL-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-DRE-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-CFA-9837999:r:Mitochondrial protein degradation", "R-CFA-5362517:r:Signaling by Retinoic Acid", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SSC-5362517:r:Signaling by Retinoic Acid", "R-RNO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DME-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-CEL-6783984:r:Glycine degradation", "R-MMU-6783984:r:Glycine degradation", "R-HSA-9865125:r:Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD", "R-CEL-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SCE-6783984:r:Glycine degradation", "R-CEL-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-CEL-5362517:r:Signaling by Retinoic Acid", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9907570:r:Loss-of-function mutations in DLD cause MSUD3/DLDD", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-CFA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-RNO-6783984:r:Glycine degradation", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SSC-6783984:r:Glycine degradation", "R-RNO-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-CEL-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SCE-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-MMU-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-6783984:r:Glycine degradation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-DDI-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-5362517:r:Signaling by Retinoic Acid"], "type": "Domain"}, "IPR001019": {"description": "Guanine nucleotide binding protein, alpha subunit", "go_ids": ["GO:0007186", "GO:0019001", "GO:0003924", "GO:0031683"], "go_terms": ["GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0019001:guanyl nucleotide binding:F", "GO:0003924:GTPase activity:F", "GO:0031683:G-protein beta/gamma-subunit complex binding:F"], "name": "Gprotein_alpha_su", "pathway_ids": ["R-BTA-392170", "R-RNO-418592", "R-BTA-112043", "R-MMU-381771", "R-MMU-4086398", "R-HSA-2485179", "R-RNO-9009391", "R-DME-170670", "R-MMU-9009391", "R-BTA-2514859", "R-DDI-416476", "R-BTA-400042", "R-MMU-456926", "R-DME-9013148", "R-HSA-432040", "R-DME-170660", "R-GGA-9009391", "R-CEL-9717207", "R-CFA-392170", "R-CFA-456926", "R-CEL-4086398", "R-HSA-392170", "R-RNO-416476", "R-DDI-399997", "R-RNO-193648", "R-DDI-2485179", "R-DME-9013149", "R-HSA-434316", "R-MMU-112043", "R-HSA-392851", "R-HSA-418592", "R-RNO-9717207", "R-MMU-9634597", "R-HSA-418555", "R-HSA-416482", "R-HSA-400042", "R-RNO-9013148", "R-RNO-112043", "R-CEL-456926", "R-MMU-432040", "R-MMU-420092", "R-RNO-456926", "R-CFA-418594", "R-SSC-6814122", "R-DME-112043", "R-DME-193648", "R-HSA-164378", "R-HSA-418597", "R-DME-416482", "R-MMU-399997", "R-MMU-193648", "R-CEL-170670", "R-CFA-416476", "R-CEL-418597", "R-MMU-392170", "R-SSC-418592", "R-MMU-9860927", "R-HSA-9634597", "R-CFA-9856530", "R-MMU-418597", "R-RNO-400042", "R-MMU-418594", "R-RNO-399997", "R-RNO-418594", "R-RNO-9860927", "R-CFA-399997", "R-BTA-4086398", "R-SCE-418594", "R-BTA-381771", "R-RNO-416482", "R-HSA-9013148", "R-MMU-392851", "R-DDI-418594", "R-CFA-418592", "R-DME-416476", "R-HSA-4086398", "R-MMU-400042", "R-BTA-9717207", "R-CFA-170670", "R-BTA-6814122", "R-SSC-9860927", "R-RNO-434316", "R-CEL-193648", "R-RNO-170660", "R-GGA-392170", "R-CEL-2485179", "R-BTA-456926", "R-DDI-112043", "R-DME-418594", "R-BTA-399997", "R-DDI-2514859", "R-BTA-9009391", "R-CFA-434316", "R-SSC-416476", "R-RNO-9856530", "R-HSA-9009391", "R-HSA-9717207", "R-MMU-170660", "R-CEL-392170", "R-HSA-6814122", "R-DDI-4086398", "R-MMU-2485179", "R-HSA-9856530", "R-RNO-432040", "R-MMU-9013149", "R-SCE-2514859", "R-BTA-9856530", "R-DME-9856530", "R-MMU-418555", "R-HSA-422356", "R-DME-202040", "R-MMU-416476", "R-CFA-112043", "R-RNO-392170", "R-RNO-418597", "R-DME-428930", "R-HSA-381753", "R-DDI-170660", "R-RNO-9013149", "R-CEL-416482", "R-BTA-202040", "R-MMU-381676", "R-SSC-9856530", "R-MMU-202040", "R-BTA-418594", "R-MMU-9717207", "R-RNO-420092", "R-HSA-202040", "R-MMU-428930", "R-HSA-170660", "R-CEL-428930", "R-HSA-420092", "R-MMU-434316", "R-CEL-9013148", "R-CFA-202040", "R-MMU-381753", "R-BTA-2485179", "R-DDI-418597", "R-HSA-2514859", "R-HSA-456926", "R-SSC-428930", "R-BTA-416476", "R-DDI-202040", "R-HSA-9013149", "R-DDI-9856530", "R-HSA-381676", "R-BTA-418592", "R-HSA-170670", "R-HSA-428930", "R-HSA-9860927", "R-SSC-202040", "R-DME-418592", "R-MMU-9856530", "R-SSC-399997", "R-GGA-418594", "R-CEL-400042", "R-MMU-9013148", "R-HSA-416476", "R-DME-9860927", "R-HSA-399997", "R-DDI-9013149", "R-CEL-9013149", "R-CFA-6814122", "R-SSC-112043", "R-HSA-112043", "R-DDI-170670", "R-HSA-5610787", "R-DDI-418592", "R-MMU-2514859", "R-HSA-381771", "R-HSA-163359", "R-HSA-9660821", "R-SSC-456926", "R-DME-418597", "R-MMU-6814122", "R-HSA-193648", "R-DDI-416482", "R-BTA-434316", "R-SPO-2514859", "R-CFA-9009391", "R-CFA-428930", "R-SSC-434316", "R-RNO-381676", "R-CEL-418594", "R-BTA-170670", "R-RNO-428930", "R-MMU-418592", "R-BTA-9860927", "R-RNO-4086398", "R-HSA-418594", "R-BTA-428930", "R-MMU-416482", "R-DDI-434316", "R-MMU-170670", "R-SPO-418594", "R-CEL-2514859", "R-GGA-170670", "R-RNO-202040", "R-RNO-170670"], "pathways": ["R-BTA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-112043:r:PLC beta mediated events", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-DME-170670:r:Adenylate cyclase inhibitory pathway", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-416476:r:G alpha (q) signalling events", 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"R-HSA-8964058:r:HDL remodeling", "R-HSA-8964026:r:Chylomicron clearance", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9026403:r:Biosynthesis of DPAn-3-derived 13-series resolvins", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-8964026:r:Chylomicron clearance", "R-MMU-9026290:r:Biosynthesis of DPAn-3-derived maresins", "R-HSA-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-BTA-192456:r:Digestion of dietary lipid", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9026403:r:Biosynthesis of DPAn-3-derived 13-series resolvins", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins"], "type": "Domain"}, "IPR001025": {"description": "Bromo adjacent homology (BAH) domain", "go_ids": ["GO:0003682"], "go_terms": ["GO:0003682:chromatin binding:F"], "name": "BAH_dom", "pathway_ids": ["R-HSA-4655427", "R-RNO-68949", "R-HSA-68949", "R-MMU-73762", "R-SPO-68616", "R-RNO-8943724", "R-RNO-68962", "R-HSA-69205", "R-HSA-113507", "R-HSA-427413", "R-MMU-3214815", "R-MMU-68949", "R-RNO-176187", "R-MMU-212300", "R-HSA-3214858", "R-RNO-3214815", "R-HSA-6804758", "R-DME-68962", "R-HSA-68616", "R-RNO-212300", "R-RNO-68616", "R-HSA-3214841", "R-HSA-9844594", "R-RNO-3232118", "R-HSA-9845323", "R-MMU-4655427", "R-SCE-68949", "R-HSA-8943724", "R-MMU-3232118", "R-HSA-68962", "R-SCE-176187", "R-HSA-5334118", "R-HSA-9701898", "R-HSA-176187", "R-DME-68949", "R-RNO-68689", "R-DME-176187", "R-HSA-68867", "R-SPO-176187", "R-MMU-3214841", "R-MMU-68962", "R-HSA-9933939", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-HSA-68689", "R-RNO-73762", "R-SCE-68962", "R-DME-68616", "R-MMU-3214858", "R-MMU-8939243", "R-MMU-8943724", "R-HSA-9710421", "R-RNO-4655427", "R-SCE-68616", "R-DME-68689", "R-HSA-9725371", "R-HSA-212300", "R-MMU-9933939", "R-HSA-8939243", "R-SPO-68689", "R-SCE-68689", "R-HSA-3232118", "R-MMU-6804758", "R-MMU-176187", "R-HSA-9843940", "R-HSA-427389", "R-SPO-68962", "R-SPO-68949", "R-MMU-68689", "R-MMU-68616"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-68949:r:Orc1 removal from chromatin", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-RNO-3214815:r:HDACs deacetylate histones", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-68962:r:Activation of the pre-replicative complex", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-MMU-4655427:r:SUMOylation of DNA methylation proteins", "R-SCE-68949:r:Orc1 removal from chromatin", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-5334118:r:DNA methylation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9710421:r:Defective pyroptosis", "R-RNO-4655427:r:SUMOylation of DNA methylation proteins", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SPO-68949:r:Orc1 removal from chromatin", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication"], "type": "Domain"}, "IPR001029": {"description": "Flagellin, N-terminal domain", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Flagellin_N", "pathway_ids": ["R-GGA-433822", "R-HSA-975871", "R-GGA-977240", "R-GGA-451534", "R-HSA-168176", "R-HSA-5602680", "R-HSA-5603037", "R-HSA-844623"], "pathways": ["R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-GGA-977240:r:MyD88 cascade initiated on plasma membrane", "R-GGA-451534:r:TLR5 cascade", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR001030": {"description": "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain", "go_ids": [], "go_terms": [], "name": "Acoase/IPM_deHydtase_lsu_aba", "pathway_ids": ["R-DDI-9837999", "R-MMU-71403", "R-CEL-917937", "R-HSA-9854311", "R-CEL-389542", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-9854311", "R-SPO-9854311", "R-BTA-71403", "R-DDI-917937", "R-RNO-917937", "R-MMU-389542", "R-RNO-9837999", "R-RNO-389542", "R-MMU-917937", "R-RNO-9854311", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-CEL-9854311", "R-SPO-9837999", "R-HSA-917937", "R-BTA-9837999", "R-SCE-71403", "R-SCE-9837999", "R-SSC-917937", "R-HSA-389542", "R-DDI-9854311", "R-DDI-71403", "R-HSA-1268020", "R-HSA-9837999", "R-RNO-71403", "R-DDI-389542", "R-HSA-71403", "R-SCE-9854311"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-389542:r:NADPH regeneration", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-917937:r:Iron uptake and transport", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-389542:r:NADPH regeneration", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-389542:r:NADPH regeneration", "R-MMU-917937:r:Iron uptake and transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-917937:r:Iron uptake and transport", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-SSC-917937:r:Iron uptake and transport", "R-HSA-389542:r:NADPH regeneration", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-389542:r:NADPH regeneration", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Domain"}, "IPR001031": {"description": "Thioesterase", "go_ids": ["GO:0009058"], "go_terms": ["GO:0009058:biosynthetic process:P"], "name": "Thioesterase", "pathway_ids": ["R-HSA-163765", "R-HSA-9029558", "R-HSA-75105", "R-HSA-9918487", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR001032": {"description": "Leghaemoglobin-like", "go_ids": ["GO:0019825", "GO:0020037"], "go_terms": ["GO:0019825:oxygen binding:F", "GO:0020037:heme binding:F"], "name": "Leghaemoglobin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001034": {"description": "DeoR-type HTH domain", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "DeoR_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001036": {"description": "Acriflavin resistance protein", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "Acrflvin-R", "pathway_ids": ["R-HSA-9913143", "R-SCE-8964038", "R-HSA-9760173", "R-SCE-8963678", "R-HSA-9638334"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-SCE-8964038:r:LDL clearance", "R-HSA-9760173:r:Secretion of toxins", "R-SCE-8963678:r:Intestinal lipid absorption", "R-HSA-9638334:r:Iron assimilation using enterobactin"], "type": "Family"}, "IPR001037": {"description": "Integrase, C-terminal, retroviral", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "Integrase_C_retrovir", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-164843", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164525", "R-HSA-173107", "R-HSA-162594"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Domain"}, "IPR001038": {"description": "Glycoprotein C/glycoprotein A", "go_ids": [], "go_terms": [], "name": "GA_GC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001040": {"description": "Translation Initiation factor eIF- 4e", "go_ids": ["GO:0003723", "GO:0003743", "GO:0006413"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003743:translation initiation factor activity:F", "GO:0006413:translational initiation:P"], "name": "TIF_eIF_4E", "pathway_ids": ["R-CEL-159231", "R-CEL-159227", "R-HSA-9918487", "R-MMU-72706", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-CEL-159230", "R-DRE-166208", "R-DDI-72662", "R-SCE-72702", "R-DME-72662", "R-RNO-156827", "R-SPO-72706", "R-HSA-429947", "R-SCE-72662", "R-HSA-72706", "R-DME-159227", "R-CEL-72662", "R-HSA-72702", "R-RNO-429947", "R-CEL-156827", "R-HSA-159231", "R-RNO-72649", "R-MMU-159227", "R-DRE-72662", "R-DRE-159227", "R-DME-110523", "R-CEL-72649", "R-HSA-9820841", "R-SPO-156827", "R-DME-72702", "R-RNO-72662", "R-SPO-429947", "R-DDI-72702", "R-HSA-72662", "R-SCE-429947", "R-SPO-72702", "R-DME-156827", "R-SPO-159227", "R-DME-429947", "R-SPO-159231", "R-DRE-159231", "R-CEL-72702", "R-DME-159231", "R-DME-72649", "R-HSA-156827", "R-HSA-1169408", "R-MMU-72649", "R-RNO-166208", "R-HSA-159227", "R-HSA-9820865", "R-HSA-166208", "R-MMU-429947", "R-MMU-72662", "R-DME-166208", "R-MMU-159231", "R-DDI-1169408", "R-DRE-156827", "R-SPO-72662", "R-SCE-156827", "R-MMU-72702", "R-SPO-72649", "R-DDI-166208", "R-RNO-72702", "R-MMU-1169408", "R-RNO-159227", "R-HSA-72649", "R-MMU-156827", "R-DME-159230", "R-DRE-72649", "R-SCE-72649", "R-CEL-1169408", "R-DRE-72702", "R-RNO-159231", "R-MMU-166208", "R-DDI-156827"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DRE-166208:r:mTORC1-mediated signalling", "R-DDI-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-429947:r:Deadenylation of mRNA", "R-SCE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-429947:r:Deadenylation of mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-72649:r:Translation initiation complex formation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-110523:r:TOR signaling pathway", "R-CEL-72649:r:Translation initiation complex formation", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SPO-429947:r:Deadenylation of mRNA", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-429947:r:Deadenylation of mRNA", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-429947:r:Deadenylation of mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-72649:r:Translation initiation complex formation", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-166208:r:mTORC1-mediated signalling", "R-MMU-429947:r:Deadenylation of mRNA", "R-MMU-72662:r:Activation of the mRNA upon binding of the 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expression", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DRE-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-166208:r:mTORC1-mediated signalling", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression"], "type": "Family"}, "IPR001041": {"description": "2Fe-2S ferredoxin-type iron-sulfur binding domain", "go_ids": ["GO:0051536"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F"], "name": "2Fe-2S_ferredoxin-type", "pathway_ids": ["R-HSA-1362409", "R-DRE-211976", "R-HSA-8851680", "R-HSA-6799198", "R-RNO-6799198", "R-RNO-9857492", "R-BTA-211976", "R-GGA-372987", "R-SPO-189451", "R-SPO-71403", "R-HSA-74259", "R-CEL-71403", "R-SCE-2395516", "R-DME-74259", "R-BTA-9837999", "R-DME-9857492", "R-MMU-9854311", "R-MMU-71403", "R-BTA-6799198", "R-RNO-9748787", "R-SSC-196108", "R-HSA-71403", "R-DME-1362409", "R-MMU-9748787", "R-HSA-196108", "R-DRE-196108", "R-HSA-9854311", "R-MMU-9857492", "R-RNO-1362409", "R-MMU-6799198", "R-DRE-2395516", "R-HSA-5579026", "R-MMU-2395516", "R-BTA-9857492", "R-SCE-9857492", "R-DDI-6799198", "R-DME-611105", "R-RNO-611105", "R-RNO-9854311", "R-SSC-1362409", "R-RNO-2395516", "R-HSA-9748787", "R-RNO-964975", "R-MMU-211976", "R-BTA-196108", "R-RNO-211976", "R-DDI-964975", "R-HSA-211976", "R-XTR-71403", "R-DME-2395516", "R-BTA-611105", "R-DDI-74259", "R-MMU-9837999", "R-DDI-9748787", "R-HSA-964975", "R-RNO-74259", "R-DME-6799198", "R-DME-964975", "R-DRE-9854311", "R-DRE-1362409", "R-SSC-211976", "R-BTA-2395516", "R-MMU-196108", "R-MMU-1362409", "R-MMU-964975", "R-MMU-611105", "R-DME-9748787", "R-BTA-1362409", "R-HSA-9837999", "R-RNO-71403", "R-DDI-71403", "R-DDI-9837999", "R-RNO-8851680", "R-SCE-1362409", "R-GGA-421178", 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"R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SSC-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-2395516:r:Electron transport from NADPH to Ferredoxin", "R-HSA-9748787:r:Azathioprine ADME", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-211976:r:Endogenous sterols", "R-BTA-196108:r:Pregnenolone biosynthesis", "R-RNO-211976:r:Endogenous sterols", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-HSA-211976:r:Endogenous sterols", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-DME-2395516:r:Electron transport from NADPH to Ferredoxin", "R-BTA-611105:r:Respiratory electron transport", "R-DDI-74259:r:Purine catabolism", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-9748787:r:Azathioprine ADME", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-74259:r:Purine catabolism", 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"R-GGA-421178:r:Urate synthesis", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-2395516:r:Electron transport from NADPH to Ferredoxin", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9857492:r:Protein lipoylation", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-611105:r:Respiratory electron transport", "R-SSC-9857492:r:Protein lipoylation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-74259:r:Purine catabolism", "R-SSC-2395516:r:Electron transport from NADPH to Ferredoxin"], "type": "Domain"}, "IPR001044": {"description": "XPG/Rad2 endonuclease, eukaryotes", "go_ids": ["GO:0003697", "GO:0004519", "GO:0005634", "GO:0006289"], "go_terms": ["GO:0003697:single-stranded DNA binding:F", "GO:0004519:endonuclease activity:F", "GO:0005634:nucleus:C", "GO:0006289:nucleotide-excision repair:P"], "name": "XPG/Rad2_eukaryotes", "pathway_ids": ["R-SPO-5696395", "R-MMU-5696395", "R-SPO-5696400", "R-MMU-6782135", "R-HSA-5696395", "R-HSA-5696400", "R-HSA-6782135", "R-SPO-6782135", "R-MMU-5696400", "R-SCE-6782135"], "pathways": ["R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Family"}, "IPR001045": {"description": "Spermidine/spermine synthases", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Spermi_synthase", "pathway_ids": ["R-SPO-351202", "R-MMU-351202", "R-SCE-351202", "R-HSA-351202", "R-DDI-351202"], "pathways": ["R-SPO-351202:r:Metabolism of polyamines", "R-MMU-351202:r:Metabolism of polyamines", "R-SCE-351202:r:Metabolism of polyamines", "R-HSA-351202:r:Metabolism of polyamines", "R-DDI-351202:r:Metabolism of polyamines"], "type": "Family"}, "IPR001046": {"description": "NRAMP family", "go_ids": ["GO:0030001", "GO:0046873", "GO:0016020"], "go_terms": ["GO:0030001:metal ion transport:P", "GO:0046873:metal ion transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "NRAMP_fam", "pathway_ids": ["R-HSA-6798695", "R-MMU-1222556", "R-CEL-1222556", "R-PFA-917937", "R-RNO-6803544", "R-HSA-6803544", "R-GGA-425410", "R-DME-1222556", "R-CEL-6798695", "R-MMU-425410", "R-RNO-1222556", "R-DME-425410", "R-MMU-917937", "R-DME-6803544", "R-HSA-1222556", "R-PFA-6803544", "R-RNO-425410", "R-PFA-425410", "R-HSA-425410", "R-DDI-1222556", "R-MMU-6803544", "R-HSA-5619048", "R-GGA-6803544", "R-DME-917937", "R-CEL-6803544", "R-DDI-6798695", "R-CEL-917937", "R-RNO-917937", "R-DME-6798695", "R-DDI-917937", "R-CEL-425410", "R-GGA-6798695", "R-DDI-6803544", "R-PFA-1222556", "R-HSA-917937", "R-PFA-6798695", "R-MMU-6798695", "R-GGA-1222556", "R-DDI-425410", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-PFA-917937:r:Iron uptake and transport", "R-RNO-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-GGA-425410:r:Metal ion SLC transporters", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-425410:r:Metal ion SLC transporters", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-DME-425410:r:Metal ion SLC transporters", "R-MMU-917937:r:Iron uptake and transport", "R-DME-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-PFA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-RNO-425410:r:Metal ion SLC transporters", "R-PFA-425410:r:Metal ion SLC transporters", "R-HSA-425410:r:Metal ion SLC transporters", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-MMU-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-5619048:r:Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)", "R-GGA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-DME-917937:r:Iron uptake and transport", "R-CEL-6803544:r:Ion influx/efflux at host-pathogen interface", "R-DDI-6798695:r:Neutrophil degranulation", "R-CEL-917937:r:Iron uptake and transport", "R-RNO-917937:r:Iron uptake and transport", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-917937:r:Iron uptake and transport", 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"R-SPO-1799339", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-SCE-156827", "R-MMU-72702", "R-DME-72695", "R-DME-975956", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-HSA-9754678", "R-HSA-72649", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-SPO-6791226", "R-SCE-72649", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and 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Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001048": {"description": "Aspartate/glutamate/uridylate kinase", "go_ids": [], "go_terms": [], "name": "Asp/Glu/Uridylate_kinase", "pathway_ids": ["R-HSA-8964539", "R-SPO-70635", "R-HSA-9955693", "R-MMU-9837999", "R-CEL-9837999", "R-MMU-8964539", "R-CEL-8964539", "R-HSA-9837999", "R-HSA-70635", "R-DDI-70635", "R-SCE-70635"], "pathways": ["R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-SPO-70635:r:Urea cycle", "R-HSA-9955693:r:NAGS 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"R-HSA-3560801", "R-RNO-381426", "R-HSA-4420332", "R-BTA-3000170", "R-HSA-449836", "R-DME-381426", "R-DME-8957275", "R-DME-1971475", "R-CEL-2024096", "R-BTA-2024096", "R-HSA-3656253", "R-RNO-8957275", "R-SSC-1971475", "R-BTA-381426", "R-HSA-2024096", "R-RNO-3928662", "R-MMU-2022928", "R-RNO-3000170", "R-HSA-2022928", "R-HSA-9833110", "R-RNO-975634", "R-BTA-449836", "R-HSA-9918481", "R-DME-2024096", "R-HSA-3000170", "R-SSC-2024096", "R-BTA-2022928", "R-SSC-975634", "R-RNO-1971475", "R-DME-2022928", "R-DME-3000170", "R-CEL-1971475", "R-RNO-2022928", "R-MMU-3928662", "R-HSA-8957275", "R-MMU-1971475", "R-RNO-449836", "R-HSA-202733", "R-HSA-975634"], "pathways": ["R-SSC-3000170:r:Syndecan interactions", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-3656237:r:Defective EXT2 causes 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"R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-9694614:r:Attachment and Entry", "R-BTA-975634:r:Retinoid metabolism and transport", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-BTA-3000170:r:Syndecan interactions", "R-HSA-449836:r:Other interleukin signaling", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", 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"R-DDI-170660", "R-MMU-8935690", "R-RNO-5610787", "R-MMU-445355", "R-DME-445355", "R-SSC-8935690", "R-SPO-9013106", "R-HSA-432040", "R-DME-170660", "R-HSA-442720", "R-MMU-5610787", "R-HSA-170660", "R-HSA-8942233", "R-DME-5610787", "R-BTA-5578768", "R-MMU-5578768", "R-DDI-418597", "R-HSA-2514859", "R-RNO-5578768", "R-HSA-418555", "R-HSA-400042", "R-BTA-418597", "R-SPO-8980692", "R-SPO-9652282", "R-BTA-445355", "R-RNO-163615", "R-HSA-381676", "R-HSA-164378", "R-HSA-418597", "R-BTA-170660", "R-HSA-170670", "R-HSA-8935690", "R-HSA-9664323", "R-RNO-2514859", "R-PFA-936837", "R-HSA-9634597", "R-HSA-392154", "R-MMU-418597", "R-BTA-163615", "R-RNO-400042", "R-HSA-5578768", "R-RNO-445355", "R-DDI-170670", "R-HSA-5610787", "R-DME-163615", "R-MMU-2514859", "R-DDI-163615", "R-MMU-163615", "R-SPO-983168", "R-SPO-6803207", "R-MMU-400042", "R-HSA-163359", "R-HSA-9660821", "R-DME-418597", "R-RNO-170660", "R-DDI-5610787", "R-HSA-445355", "R-RNO-8935690", "R-DDI-2514859", "R-BTA-170670", "R-HSA-418594", "R-MMU-170660", "R-PFA-6798695", "R-SPO-199418", "R-MMU-170670", "R-HSA-9856530", "R-BTA-5610787", "R-HSA-163615", "R-RNO-170670"], "pathways": ["R-SPO-5223345:r:Miscellaneous transport and binding events", "R-RNO-418597:r:G alpha (z) signalling events", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-DME-170670:r:Adenylate cyclase inhibitory pathway", "R-DDI-170660:r:Adenylate cyclase activating pathway", "R-MMU-8935690:r:Digestion", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-SSC-8935690:r:Digestion", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-170660:r:Adenylate cyclase activating pathway", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-170660:r:Adenylate cyclase activating pathway", "R-HSA-8942233:r:Intestinal infectious diseases", "R-DME-5610787:r:Hedgehog 'off' state", "R-BTA-5578768:r:Physiological factors", "R-MMU-5578768:r:Physiological factors", "R-DDI-418597:r:G alpha (z) signalling events", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-5578768:r:Physiological factors", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-BTA-418597:r:G alpha (z) signalling events", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-BTA-445355:r:Smooth Muscle Contraction", "R-RNO-163615:r:PKA activation", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-164378:r:PKA activation in glucagon signalling", "R-HSA-418597:r:G alpha (z) signalling events", "R-BTA-170660:r:Adenylate cyclase activating pathway", "R-HSA-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-8935690:r:Digestion", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-PFA-936837:r:Ion transport by P-type ATPases", "R-HSA-9634597:r:GPER1 signaling", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-418597:r:G alpha (z) signalling events", "R-BTA-163615:r:PKA activation", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-5578768:r:Physiological factors", "R-RNO-445355:r:Smooth Muscle Contraction", "R-DDI-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-163615:r:PKA activation", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-163615:r:PKA activation", "R-MMU-163615:r:PKA activation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-DME-418597:r:G alpha (z) signalling events", "R-RNO-170660:r:Adenylate cyclase activating pathway", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-8935690:r:Digestion", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-170660:r:Adenylate cyclase activating pathway", "R-PFA-6798695:r:Neutrophil degranulation", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-163615:r:PKA activation", "R-RNO-170670:r:Adenylate cyclase inhibitory pathway"], "type": "Domain"}, "IPR001055": {"description": "Adrenodoxin-like", "go_ids": ["GO:0051537", "GO:0140647"], "go_terms": ["GO:0051537:2 iron, 2 sulfur cluster binding:F", "GO:0140647:P450-containing electron transport chain:P"], "name": "Adrenodoxin-like", "pathway_ids": ["R-HSA-1362409", "R-DRE-211976", "R-RNO-9857492", "R-DRE-1362409", "R-BTA-211976", "R-SSC-211976", "R-BTA-2395516", "R-SPO-189451", "R-MMU-196108", "R-DME-9857492", "R-SCE-2395516", "R-MMU-1362409", "R-BTA-1362409", "R-SSC-196108", "R-DME-1362409", "R-HSA-196108", "R-DRE-196108", "R-MMU-9857492", "R-RNO-1362409", "R-SCE-1362409", "R-DRE-2395516", "R-HSA-2395516", "R-HSA-5579026", "R-MMU-2395516", "R-BTA-9857492", "R-SCE-9857492", "R-RNO-196108", "R-HSA-9857492", "R-SSC-9857492", "R-SSC-1362409", "R-RNO-2395516", "R-MMU-211976", "R-BTA-196108", "R-RNO-211976", "R-HSA-211976", "R-DME-2395516", "R-SSC-2395516"], "pathways": ["R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DRE-211976:r:Endogenous sterols", "R-RNO-9857492:r:Protein lipoylation", "R-DRE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-BTA-211976:r:Endogenous sterols", "R-SSC-211976:r:Endogenous sterols", "R-BTA-2395516:r:Electron transport from NADPH to Ferredoxin", "R-SPO-189451:r:Heme biosynthesis", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-DME-9857492:r:Protein lipoylation", "R-SCE-2395516:r:Electron transport from NADPH to Ferredoxin", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-BTA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SSC-196108:r:Pregnenolone biosynthesis", "R-DME-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-DRE-196108:r:Pregnenolone biosynthesis", "R-MMU-9857492:r:Protein lipoylation", "R-RNO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DRE-2395516:r:Electron transport from NADPH to Ferredoxin", "R-HSA-2395516:r:Electron transport from NADPH to Ferredoxin", "R-HSA-5579026:r:Defective CYP11A1 causes AICSR", "R-MMU-2395516:r:Electron transport from NADPH to Ferredoxin", "R-BTA-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-HSA-9857492:r:Protein lipoylation", "R-SSC-9857492:r:Protein lipoylation", "R-SSC-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-2395516:r:Electron transport from NADPH to Ferredoxin", "R-MMU-211976:r:Endogenous sterols", "R-BTA-196108:r:Pregnenolone biosynthesis", "R-RNO-211976:r:Endogenous sterols", "R-HSA-211976:r:Endogenous sterols", "R-DME-2395516:r:Electron transport from NADPH to Ferredoxin", "R-SSC-2395516:r:Electron transport from NADPH to Ferredoxin"], "type": "Family"}, "IPR001056": {"description": "Photosystem II reaction centre protein H", "go_ids": ["GO:0009523", "GO:0016020", "GO:0042301", "GO:0050821", "GO:0015979"], "go_terms": ["GO:0009523:photosystem II:C", "GO:0016020:membrane:C", "GO:0042301:phosphate ion binding:F", "GO:0050821:protein stabilization:P", "GO:0015979:photosynthesis:P"], "name": "PSII_PsbH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001058": {"description": "Synuclein", "go_ids": [], "go_terms": [], "name": "Synuclein", "pathway_ids": ["R-SSC-9833482", "R-MMU-9833482", "R-HSA-9833482", "R-HSA-5660489", "R-BTA-9833482", "R-RNO-9833482", "R-HSA-977225"], "pathways": ["R-SSC-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-5660489:r:MTF1 activates gene expression", "R-BTA-9833482:r:PKR-mediated signaling", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-977225:r:Amyloid fiber formation"], "type": "Family"}, "IPR001059": {"description": "Translation elongation factor P/YeiP, central", "go_ids": ["GO:0003746", "GO:0006414"], "go_terms": ["GO:0003746:translation elongation factor activity:F", "GO:0006414:translational elongation:P"], "name": "Transl_elong_P/YeiP_cen", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001060": {"description": "FCH domain", "go_ids": [], "go_terms": [], "name": "FCH_dom", "pathway_ids": ["R-HSA-9013409", "R-MMU-8856828", "R-HSA-6798695", "R-HSA-8856828", "R-RNO-9013149", "R-DRE-9013406", "R-MMU-9013420", "R-SCE-8980692", "R-SCE-9013149", "R-MMU-399954", "R-HSA-399955", "R-DDI-8856828", "R-RNO-9013406", "R-DRE-5663220", "R-HSA-203641", "R-MMU-9035034", "R-MMU-1433557", "R-HSA-9660826", "R-RNO-9013148", "R-SPO-9013148", "R-RNO-5663220", "R-SPO-8980692", "R-RNO-1433557", "R-HSA-9013149", "R-SCE-9013148", "R-MMU-9013423", "R-SCE-9035034", "R-HSA-8980692", "R-DRE-9035034", "R-HSA-399954", "R-MMU-9013406", "R-SPO-9013424", "R-MMU-6798695", "R-RNO-9013420", "R-MMU-399956", "R-MMU-5663220", "R-HSA-844456", "R-DRE-9013423", "R-SPO-6798695", "R-HSA-399956", "R-SCE-9013423", "R-MMU-8856825", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-9696270", "R-SCE-6798695", "R-MMU-9013148", "R-MMU-203641", "R-HSA-9013423", "R-HSA-9035034", "R-HSA-9013148", "R-DRE-9013149", "R-CEL-9013406", "R-RNO-8856828", "R-RNO-203641", "R-SCE-9013424", "R-BTA-8856828", "R-XTR-8856828", "R-CEL-8856828", "R-HSA-9013420", "R-RNO-8856825", "R-HSA-9696270", "R-HSA-1433557", "R-SPO-9035034", "R-MMU-844456", "R-RNO-9013423", "R-DRE-9013148", "R-HSA-428543", "R-DRE-9013420", "R-HSA-8856825", "R-HSA-5663220", "R-MMU-9696270", "R-HSA-9013406", "R-MMU-9013149"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-SPO-8980692:r:RHOA GTPase cycle", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-SCE-9035034:r:RHOF GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DRE-9035034:r:RHOF GTPase cycle", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-9013424:r:RHOV GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-844456:r:The NLRP3 inflammasome", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-SCE-9013424:r:RHOV GTPase cycle", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-SPO-9035034:r:RHOF GTPase cycle", "R-MMU-844456:r:The NLRP3 inflammasome", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-DRE-9013420:r:RHOU GTPase cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR001062": {"description": "Transcription antitermination protein, NusG", "go_ids": ["GO:0032784"], "go_terms": ["GO:0032784:regulation of DNA-templated transcription elongation:P"], "name": "Transcrpt_antiterm_NusG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001063": {"description": "Large ribosomal subunit protein uL22", "go_ids": ["GO:0006412", "GO:0003735", "GO:0005840"], "go_terms": ["GO:0006412:translation:P", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C"], "name": "Ribosomal_uL22", "pathway_ids": ["R-HSA-5419276", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9937383", "R-DME-9954716", "R-DME-72706", "R-HSA-975956", "R-CEL-975956", "R-RNO-9954716", "R-RNO-5419276", "R-DDI-9954714", "R-HSA-5368286", "R-CEL-72706", "R-RNO-9937383", "R-HSA-5389840", "R-CEL-9954716", "R-CEL-9954714", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-RNO-156827", "R-SPO-72706", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-BTA-9937383", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-XTR-5419276", "R-SPO-156827", "R-DME-5389840", "R-HSA-9954714", "R-MMU-5389840", "R-CEL-72689", "R-DDI-72689", "R-SPO-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-MMU-9937383", "R-DME-156827", "R-SCE-72706", "R-XTR-5389840", "R-HSA-156827", "R-RNO-72689", "R-HSA-192823", "R-XTR-9937383", "R-BTA-5389840", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DME-1799339", "R-DDI-9954709", "R-SCE-72689", "R-RNO-5389840", "R-SCE-156827", "R-DME-975956", "R-CEL-9954709", "R-DME-72689", "R-HSA-156902", "R-HSA-9937383", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-HSA-975957", "R-DME-9954714", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-RNO-156827:r:L13a-mediated translational 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"R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-HSA-192823:r:Viral mRNA Translation", "R-XTR-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of 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"R-BTA-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001064": {"description": "Beta/gamma crystallin", "go_ids": [], "go_terms": [], "name": "Beta/gamma_crystallin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001070": {"description": "Polyomavirus coat protein VP2", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Polyoma_coat_VP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001072": {"description": "RNA ligase, Pab1020 family", "go_ids": [], "go_terms": [], "name": "RNA_ligase_Pab1020", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001073": {"description": "C1q domain", "go_ids": [], "go_terms": [], "name": "C1q_dom", "pathway_ids": ["R-MMU-2129379", "R-DRE-114608", "R-HSA-173623", "R-MMU-977606", "R-DRE-5173105", "R-HSA-216083", "R-HSA-9920588", "R-HSA-2129379", "R-MMU-8948216", "R-HSA-381340", "R-HSA-3000171", "R-HSA-1650814", "R-MMU-173623", "R-MMU-2022090", "R-RNO-977606", "R-HSA-5173105", "R-HSA-9841922", "R-HSA-114608", "R-MMU-163680", "R-MMU-3000171", "R-HSA-2022090", "R-HSA-977606", "R-DRE-2129379", "R-MMU-1650814", "R-RNO-173623", "R-HSA-8948216", "R-MMU-216083", "R-BTA-173623", "R-HSA-166663", "R-BTA-977606", "R-MMU-1442490", "R-MMU-5173105", "R-HSA-1442490", 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"R-HSA-9833482", "R-MMU-264870"], "pathways": ["R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins"], "type": "Repeat"}, "IPR001085": {"description": "Serine hydroxymethyltransferase", "go_ids": ["GO:0006545", "GO:0030170", "GO:0035999", "GO:0004372"], "go_terms": ["GO:0006545:glycine biosynthetic process:P", "GO:0030170:pyridoxal phosphate binding:F", "GO:0035999:tetrahydrofolate interconversion:P", "GO:0004372:glycine hydroxymethyltransferase activity:F"], "name": "Ser_HO-MeTrfase", "pathway_ids": ["PWY-3661", "PWY-8363", "PWY-2201", "PWY-181", "PWY-1622", "PWY-8325", "PWY-2161", "PWY-5497", "PWY-8362", "PWY-3841", "R-MMU-9837999", "R-SCE-71262", "R-MMU-9013408", "R-HSA-196757", "R-BTA-9013408", "R-MMU-71262", "R-MMU-196757", "R-SPO-9837999", "R-SPO-71262", "R-BTA-9837999", "R-SCE-9837999", "R-BTA-196757", "R-CEL-71262", "R-HSA-9837999", "R-HSA-9013408", "R-SCE-196757", "R-SPO-196757", "R-HSA-71262", "R-CEL-196757"], "pathways": ["PWY-3661:t:glycine betaine degradation I", "PWY-8363:t:photorespiration III", "PWY-2201:t:folate transformations I", "PWY-181:t:photorespiration I", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-8325:t:glycine betaine degradation III", "PWY-2161:t:folate polyglutamylation", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8362:t:photorespiration II", "PWY-3841:t:folate transformations II (plants)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SCE-71262:r:Carnitine synthesis", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-196757:r:Metabolism of folate and pterines", "R-BTA-9013408:r:RHOG GTPase cycle", "R-MMU-71262:r:Carnitine synthesis", "R-MMU-196757:r:Metabolism of folate and pterines", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SPO-71262:r:Carnitine synthesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-196757:r:Metabolism of folate and pterines", "R-CEL-71262:r:Carnitine synthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-71262:r:Carnitine synthesis", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Family"}, "IPR001086": {"description": "Prephenate dehydratase", "go_ids": ["GO:0004664", "GO:0009094"], "go_terms": ["GO:0004664:prephenate dehydratase activity:F", "GO:0009094:L-phenylalanine biosynthetic process:P"], "name": "Preph_deHydtase", "pathway_ids": ["PWY-7432"], "pathways": ["PWY-7432:t:L-phenylalanine biosynthesis III (cytosolic, plants)"], "type": "Domain"}, "IPR001087": {"description": "GDSL lipase/esterase", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "GDSL", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521", "R-MMU-975634", "R-RNO-1482788", "R-RNO-975634", "R-HSA-975634", "R-MMU-1482788", "R-HSA-1482788"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation", "R-MMU-975634:r:Retinoid metabolism and transport", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-975634:r:Retinoid metabolism and transport", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Family"}, "IPR001088": {"description": "Glycoside hydrolase, family 4", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001090": {"description": "Ephrin, ligand binding domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "EPH_LBD", "pathway_ids": ["R-CEL-3928664", "R-MMU-3928665", "R-DRE-3928662", "R-MMU-9013408", "R-CEL-9013424", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-9824272", "R-HSA-373760", "R-HSA-3928662", "R-CEL-9013149", "R-DRE-3928664", "R-HSA-9013423", "R-MMU-9013420", "R-CEL-3928663", "R-RNO-3928665", "R-RNO-3928662", "R-HSA-2682334", "R-HSA-9696273", "R-HSA-9013408", "R-CEL-3928662", "R-MMU-3928664", "R-CEL-9013423", "R-DRE-2682334", "R-HSA-9013420", "R-HSA-3928664", "R-HSA-9696270", "R-RNO-2682334", "R-MMU-9013424", "R-MMU-2682334", "R-RNO-3928663", "R-MMU-3928663", "R-RNO-3928664", "R-CEL-3928665", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-3928663", "R-HSA-3928665", "R-CEL-2682334", "R-MMU-3928662", "R-CEL-9013420", "R-DRE-3928665", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-2892247", "R-MMU-9696273", "R-MMU-9013149", "R-DRE-3928663"], "pathways": ["R-CEL-3928664:r:Ephrin signaling", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-CEL-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9824272:r:Somitogenesis", "R-HSA-373760:r:L1CAM interactions", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DRE-3928664:r:Ephrin signaling", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928664:r:Ephrin signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse"], "type": "Domain"}, "IPR001093": {"description": "IMP dehydrogenase/GMP reductase", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "IMP_DH_GMPRt", "pathway_ids": ["R-SPO-73817", "R-HSA-6798695", "R-SPO-6798695", "R-DDI-9748787", "R-CEL-6798695", "R-SCE-6798695", "R-MMU-73817", "R-BTA-6798695", "R-SCE-73817", "R-CEL-73817", "R-DDI-73817", "R-CEL-9748787", "R-DRE-6798695", "R-MMU-74217", "R-DME-9748787", "R-RNO-73817", "R-RNO-9748787", "R-DRE-73817", "R-MMU-9748787", "R-DDI-6798695", "R-SCE-9748787", "R-DME-6798695", "R-RNO-74217", "R-DRE-9748787", "R-HSA-9679191", "R-CEL-74217", "R-HSA-9748787", "R-HSA-9854909", "R-DME-73817", "R-BTA-9748787", "R-MMU-6798695", "R-BTA-73817", "R-SPO-9748787", "R-HSA-74217", "R-HSA-73817", "R-RNO-6798695"], "pathways": ["R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-9748787:r:Azathioprine ADME", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-9748787:r:Azathioprine ADME", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-74217:r:Purine salvage", "R-DME-9748787:r:Azathioprine ADME", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-9748787:r:Azathioprine ADME", "R-DRE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-9748787:r:Azathioprine ADME", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-9748787:r:Azathioprine ADME", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-74217:r:Purine salvage", "R-DRE-9748787:r:Azathioprine ADME", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-CEL-74217:r:Purine salvage", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-9748787:r:Azathioprine ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-9748787:r:Azathioprine ADME", "R-HSA-74217:r:Purine salvage", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR001095": {"description": "Acetyl-CoA carboxylase, alpha subunit", "go_ids": ["GO:0003989", "GO:0006633", "GO:0009317", "GO:0016743"], "go_terms": ["GO:0003989:acetyl-CoA carboxylase activity:F", "GO:0006633:fatty acid biosynthetic process:P", "GO:0009317:acetyl-CoA carboxylase complex:C", "GO:0016743:carboxyl- or carbamoyltransferase activity:F"], "name": "Acetyl_CoA_COase_a_su", "pathway_ids": ["PWY-5743", "PWY-5789", "PWY-6722", "PWY-4381", "PWY-5744"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-6722:t:candicidin biosynthesis", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "PWY-5744:t:glyoxylate assimilation"], "type": "Family"}, "IPR001096": {"description": "Peptidase C13, legumain", "go_ids": ["GO:0006508", "GO:0008233"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008233:peptidase activity:F"], "name": "Peptidase_C13", "pathway_ids": ["R-MMU-1679131", "R-HSA-1679131", "R-HSA-196791", "R-HSA-2132295", "R-RNO-196791", "R-RNO-2132295", "R-RNO-1679131", "R-MMU-162791", "R-MMU-2132295", "R-BTA-162791", "R-HSA-162791"], "pathways": ["R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-1679131:r:Trafficking and processing of endosomal TLR", "R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-162791:r:Attachment of GPI anchor to uPAR", "R-HSA-162791:r:Attachment of GPI anchor to uPAR"], "type": "Family"}, "IPR001098": {"description": "DNA-directed DNA polymerase, family A, palm domain", "go_ids": ["GO:0003677", "GO:0003887", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P"], "name": "DNA-dir_DNA_pol_A_palm_dom", "pathway_ids": ["R-DME-9913635", "R-MMU-5685939", "R-MMU-6783310", "R-RNO-9913635", "R-MMU-9913635", "R-HSA-5685939", "R-HSA-6783310", "R-HSA-9913635"], "pathways": ["R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR001099": {"description": "Chalcone/stilbene synthase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Chalcone/stilbene-like_synt_N", "pathway_ids": ["PWY-7397", "PWY-6515", "PWY-7897", "PWY-5135", "PWY-6316", "PWY-6787", "R-DDI-75105", "R-DDI-199220"], "pathways": ["PWY-7397:t:naringenin biosynthesis (engineered)", "PWY-6515:t:phloridzin biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5135:t:xanthohumol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6787:t:flavonoid biosynthesis (in equisetum)", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Domain"}, "IPR001100": {"description": "Pyridine nucleotide-disulphide oxidoreductase, class I", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Pyr_nuc-diS_OxRdtase", "pathway_ids": ["R-SCE-5628897", "R-HSA-9853506", "R-BTA-5362517", "R-HSA-499943", "R-RNO-3299685", "R-DDI-9858328", "R-DDI-3299685", "R-MMU-9861559", "R-DME-499943", "R-BTA-204174", "R-BTA-6783984", "R-BTA-9859138", "R-BTA-9837999", "R-MMU-5628897", "R-CEL-9861559", "R-HSA-9912481", "R-CEL-9859138", "R-SPO-204174", "R-DDI-499943", "R-BTA-70895", "R-HSA-3299685", "R-CEL-9837999", "R-CEL-6783984", "R-CEL-9853506", "R-CEL-5362517", "R-RNO-5628897", "R-CEL-5628897", "R-HSA-9907570", "R-HSA-2408550", "R-HSA-70895", "R-MMU-3299685", "R-SPO-499943", "R-RNO-9858328", "R-HSA-9861559", "R-BTA-5628897", "R-RNO-9853506", "R-MMU-204174", "R-CEL-9858328", "R-MMU-9859138", "R-RNO-5263617", "R-MTU-870331", "R-CEL-499943", "R-MMU-9858328", "R-HSA-9912529", "R-DME-5628897", "R-HSA-9818027", "R-RNO-5362517", "R-DDI-9859138", "R-MMU-9837999", "R-BTA-5263617", "R-SPO-9861559", "R-BTA-9858328", "R-SPO-9853506", "R-HSA-5628897", "R-MMU-499943", "R-HSA-9858328", "R-SCE-3299685", "R-HSA-9636383", "R-BTA-3299685", "R-SPO-3299685", "R-MMU-70895", "R-HSA-1222541", "R-DDI-6783984", "R-HSA-9837999", "R-SPO-6783984", "R-MMU-9853506", "R-HSA-5362517", "R-HSA-9859138", "R-BTA-9853506", "R-RNO-9861559", "R-DDI-5628897", "R-HSA-204174", "R-SPO-5362517", "R-MMU-6783984", "R-SCE-9853506", "R-RNO-204174", "R-SPO-5628897", "R-BTA-9861559", "R-SCE-6783984", "R-CEL-204174", "R-SCE-499943", "R-CEL-3299685", "R-RNO-9837999", "R-RNO-70895", "R-RNO-6783984", "R-DDI-9853506", "R-DME-5263617", "R-RNO-9859138", "R-SCE-9861559", "R-BTA-499943", "R-MMU-5362517", "R-HSA-6783984", "R-HSA-9865113", "R-DME-3299685", "R-DDI-9861559", "R-RNO-499943"], "pathways": ["R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-BTA-5362517:r:Signaling by Retinoic Acid", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-BTA-6783984:r:Glycine degradation", "R-BTA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-CEL-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-CEL-9837999:r:Mitochondrial protein degradation", 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BCAA-CoA from KIC, KMVA, KIV", "R-RNO-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-MTU-870331:r:Mycothiol metabolism", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-RNO-5362517:r:Signaling by Retinoic Acid", "R-DDI-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-SPO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-HSA-1222541:r:Cell redox homeostasis", "R-DDI-6783984:r:Glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-RNO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-MMU-6783984:r:Glycine degradation", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SCE-6783984:r:Glycine degradation", "R-CEL-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-RNO-6783984:r:Glycine degradation", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-DME-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-RNO-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SCE-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-6783984:r:Glycine degradation", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR001101": {"description": "Plectin repeat", "go_ids": ["GO:0005856"], "go_terms": ["GO:0005856:cytoskeleton:C"], "name": "Plectin_repeat", "pathway_ids": ["R-HSA-6798695", "R-HSA-6809371", "R-DRE-9696273", "R-HSA-8851680", "R-RNO-351906", "R-HSA-9013424", "R-HSA-351906", "R-DRE-9696264", "R-MMU-9013420", "R-DRE-6798695", "R-RNO-6805567", "R-HSA-446107", "R-HSA-6805567", "R-RNO-6809371", "R-HSA-9013420", "R-RNO-446107", "R-MMU-446107", "R-HSA-9696270", "R-DRE-6805567", "R-DRE-6809371", "R-MMU-9013424", "R-MMU-351906", "R-RNO-9696273", "R-HSA-9696264", "R-MMU-8851680", "R-MMU-6809371", "R-HSA-2022090", "R-MMU-264870", "R-RNO-9696264", "R-DRE-351906", "R-MMU-6798695", "R-RNO-264870", "R-MMU-9696264", "R-HSA-264870", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-6805567", "R-RNO-6798695", "R-HSA-9696273"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-DRE-9696273:r:RND1 GTPase cycle", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-9696264:r:RND3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6805567:r:Keratinization", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6805567:r:Keratinization", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-6805567:r:Keratinization", "R-DRE-6809371:r:Formation of the cornified envelope", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-6805567:r:Keratinization", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Repeat"}, "IPR001102": {"description": "Transglutaminase, N-terminal", "go_ids": ["GO:0018149"], "go_terms": ["GO:0018149:peptide cross-linking:P"], "name": "Transglutaminase_N", "pathway_ids": ["R-HSA-114608", "R-RNO-6809371", "R-MMU-6809371", "R-HSA-6809371", "R-MMU-140875", "R-RNO-140875", "R-HSA-6785807", "R-HSA-140875", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-RNO-6809371:r:Formation of the cornified envelope", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR001103": {"description": "Androgen receptor", "go_ids": ["GO:0004879", "GO:0003677", "GO:0005496", "GO:0005634", "GO:0006355", "GO:0030521"], "go_terms": ["GO:0004879:nuclear receptor activity:F", "GO:0003677:DNA binding:F", "GO:0005496:steroid binding:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0030521:androgen receptor signaling pathway:P"], "name": "Andrgn_rcpt", "pathway_ids": ["R-SSC-3371497", "R-SSC-4090294", "R-HSA-5689880", "R-MMU-8940973", "R-RNO-3371497", "R-HSA-3371497", "R-HSA-8940973", "R-HSA-5625886", "R-SSC-5625886", "R-RNO-5689880", "R-MMU-5689880", "R-HSA-383280", "R-MMU-383280", "R-SSC-383280", "R-RNO-5625886", "R-HSA-4090294", "R-MMU-5625886", "R-SSC-5689880", "R-SSC-8940973", "R-MMU-4090294", "R-RNO-4090294", "R-RNO-383280", "R-MMU-3371497"], "pathways": ["R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SSC-4090294:r:SUMOylation of intracellular receptors", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-8940973:r:RUNX2 regulates osteoblast differentiation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SSC-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-SSC-383280:r:Nuclear Receptor transcription pathway", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SSC-5689880:r:Ub-specific processing proteases", "R-SSC-8940973:r:RUNX2 regulates osteoblast differentiation", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "type": "Family"}, "IPR001104": {"description": "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal", "go_ids": ["GO:0006629", "GO:0016627"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0016627:oxidoreductase activity, acting on the CH-CH group of donors:F"], "name": "3-oxo-5_a-steroid_4-DH_C", "pathway_ids": ["R-DRE-193048", "R-DME-193048", "R-XTR-193048", "R-XTR-446199", "R-RNO-75876", "R-SCE-446199", "R-MMU-75876", "R-CEL-193048", "R-RNO-193048", "R-HSA-446199", "R-BTA-193048", "R-SPO-193048", "R-RNO-446199", "R-SCE-75876", "R-DME-446199", "R-CEL-446199", "R-HSA-4755579", "R-CEL-75876", "R-SPO-446199", "R-SCE-193048", "R-DDI-75876", "R-HSA-193048", "R-BTA-75876", "R-DRE-446199", "R-MMU-193048", "R-MMU-446199", "R-SPO-75876", "R-HSA-75876"], "pathways": ["R-DRE-193048:r:Androgen biosynthesis", "R-DME-193048:r:Androgen biosynthesis", "R-XTR-193048:r:Androgen biosynthesis", "R-XTR-446199:r:Synthesis of dolichyl-phosphate", "R-RNO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-SCE-446199:r:Synthesis of dolichyl-phosphate", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-CEL-193048:r:Androgen biosynthesis", "R-RNO-193048:r:Androgen biosynthesis", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-193048:r:Androgen biosynthesis", "R-SPO-193048:r:Androgen biosynthesis", "R-RNO-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-DME-446199:r:Synthesis of dolichyl-phosphate", "R-CEL-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-4755579:r:Defective SRD5A3 causes SRD5A3-CDG, KHRZ", "R-CEL-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-193048:r:Androgen biosynthesis", "R-DDI-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-193048:r:Androgen biosynthesis", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-MMU-193048:r:Androgen biosynthesis", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-SPO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs"], "type": "Domain"}, "IPR001106": {"description": "Aromatic amino acid lyase", "go_ids": [], "go_terms": [], "name": "Aromatic_Lyase", "pathway_ids": ["PWY-5030", "PWY-5028", "R-MMU-70921", "R-RNO-70921", "R-CEL-70921", 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"R-BTA-9696264", "R-DME-8949664", "R-RNO-5675482", "R-SSC-9013106", "R-HSA-9013406", "R-MMU-9696273", "R-XTR-382556", "R-HSA-9696273"], "pathways": ["R-CEL-373753:r:Nephrin family interactions", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9013026:r:RHOB GTPase cycle", "R-CEL-8980692:r:RHOA GTPase cycle", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-6798695:r:Neutrophil degranulation", "R-GGA-8949664:r:Processing of SMDT1", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-SSC-9013026:r:RHOB GTPase cycle", "R-RNO-373753:r:Nephrin family interactions", "R-CEL-5673000:r:RAF activation", "R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-5673000:r:RAF activation", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-XTR-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-8949664:r:Processing of SMDT1", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DME-5673000:r:RAF activation", "R-HSA-373753:r:Nephrin family interactions", "R-RNO-5673000:r:RAF activation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-9013407:r:RHOH GTPase cycle", "R-DRE-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-MMU-5673000:r:RAF activation", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-373753:r:Nephrin family interactions", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-8949664:r:Processing of SMDT1", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-SSC-5213460:r:RIPK1-mediated regulated necrosis", "R-BTA-5673000:r:RAF activation", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-GGA-5673000:r:RAF activation", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-8949664:r:Processing of SMDT1", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-SSC-8849932:r:Synaptic adhesion-like molecules", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-BTA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-2672351:r:Stimuli-sensing channels", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SSC-8980692:r:RHOA GTPase cycle", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-MMU-8949664:r:Processing of SMDT1", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-BTA-9840373:r:Cellular response to mitochondrial stress", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-BTA-8949664:r:Processing of SMDT1", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-CEL-2672351:r:Stimuli-sensing channels", "R-MMU-9013026:r:RHOB GTPase cycle", "R-BTA-9696264:r:RND3 GTPase cycle", "R-DME-8949664:r:Processing of SMDT1", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-XTR-382556:r:ABC-family proteins mediated transport", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR001108": {"description": "Peptidase A22A, presenilin", "go_ids": ["GO:0016020", "GO:0042500", "GO:0016485"], "go_terms": ["GO:0016020:membrane:C", "GO:0042500:aspartic endopeptidase activity, intramembrane cleaving:F", "GO:0016485:protein processing:P"], "name": "Peptidase_A22A", "pathway_ids": ["R-HSA-6798695", "R-MMU-9839383", "R-SSC-1251985", "R-HSA-2122948", "R-MMU-3928665", "R-RNO-9017802", "R-CEL-6798695", "R-HSA-1251985", "R-SSC-193692", "R-BTA-9839383", "R-BTA-6798695", "R-DRE-193692", "R-RNO-193692", "R-CEL-1251985", "R-HSA-9017802", "R-MMU-193692", "R-DRE-9839383", "R-HSA-2979096", "R-HSA-9013700", "R-MMU-9013507", "R-DRE-6798695", "R-RNO-3928665", "R-BTA-1251985", "R-RNO-205043", "R-DME-3928665", "R-HSA-9013507", "R-DME-1251985", "R-MMU-205043", "R-RNO-1251985", "R-HSA-1474228", "R-DDI-6798695", "R-DME-6798695", "R-HSA-205043", "R-HSA-2894862", "R-RNO-9839383", "R-RNO-9013507", "R-HSA-9839383", "R-MMU-9017802", "R-CEL-3928665", "R-MMU-1251985", "R-SSC-9839383", "R-BTA-193692", "R-HSA-3928665", "R-SSC-3928665", "R-MMU-6798695", "R-DRE-3928665", "R-HSA-2644606", "R-BTA-3928665", "R-DRE-1251985", "R-BTA-205043", "R-HSA-193692", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-SSC-1251985:r:Nuclear signaling by ERBB4", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-193692:r:Regulated proteolysis of p75NTR", "R-BTA-9839383:r:TGFBR3 PTM regulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DRE-193692:r:Regulated proteolysis of p75NTR", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-DRE-9839383:r:TGFBR3 PTM regulation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-SSC-9839383:r:TGFBR3 PTM regulation", "R-BTA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR001109": {"description": "Hydrogenase expression/formation protein, HupF/HypC", "go_ids": [], "go_terms": [], "name": "Hydrogenase_HupF/HypC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001111": {"description": "TGF-beta, propeptide", "go_ids": [], "go_terms": [], "name": "TGF-b_propeptide", "pathway_ids": ["R-SSC-3000170", "R-DME-2173789", "R-HSA-9839406", "R-SSC-2173788", "R-MMU-9839406", "R-MMU-8941858", "R-HSA-3000178", "R-DME-2173788", "R-MMU-2173791", "R-BTA-2173789", "R-HSA-9617828", "R-MMU-8957275", "R-MMU-3000170", "R-BTA-8957275", "R-HSA-9844594", "R-MMU-381426", "R-HSA-8941855", "R-SSC-1502540", "R-SSC-9839389", "R-DME-8941855", "R-HSA-8878166", "R-RNO-9839406", "R-HSA-9834899", "R-HSA-381426", "R-HSA-2173789", "R-HSA-8951936", "R-SSC-9839406", "R-HSA-3645790", "R-SSC-2473224", "R-HSA-9830364", "R-DME-114608", "R-HSA-8941858", "R-BTA-1502540", "R-HSA-1502540", "R-HSA-6785807", "R-DME-2173791", "R-RNO-8941855", "R-RNO-2173791", "R-RNO-381426", "R-RNO-8951936", "R-DME-8951936", "R-RNO-209822", "R-HSA-9793380", "R-RNO-1502540", "R-HSA-5689603", "R-HSA-168277", "R-HSA-3642279", 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"R-HSA-9758920", "R-HSA-9761174", "R-HSA-8957275", "R-MMU-2473224", "R-SSC-8951936", "R-HSA-2173788", "R-HSA-1433617", "R-HSA-202733", "R-MMU-2129379"], "pathways": ["R-SSC-3000170:r:Syndecan interactions", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-SSC-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-3000178:r:ECM proteoglycans", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-3000170:r:Syndecan interactions", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-SSC-1502540:r:Signaling by Activin", "R-SSC-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-DME-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-RNO-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-SSC-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-SSC-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-9830364:r:Formation of the nephric duct", "R-DME-114608:r:Platelet degranulation", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-1502540:r:Signaling by Activin", "R-HSA-1502540:r:Signaling by Activin", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8951936:r:RUNX3 regulates p14-ARF", "R-DME-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-209822:r:Glycoprotein hormones", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-1502540:r:Signaling by Activin", "R-HSA-5689603:r:UCH proteinases", "R-HSA-168277:r:Influenza Virus Induced Apoptosis", "R-HSA-3642279:r:TGFBR2 MSI Frameshift Mutants in Cancer", "R-DME-201451:r:Signaling by BMP", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-114608:r:Platelet degranulation", "R-BTA-209822:r:Glycoprotein hormones", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-SSC-114608:r:Platelet degranulation", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SSC-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-RNO-114608:r:Platelet degranulation", "R-SSC-201451:r:Signaling by BMP", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-1181150:r:Signaling by NODAL", "R-SSC-2129379:r:Molecules associated with elastic fibres", "R-HSA-9827857:r:Specification of primordial germ cells", "R-SSC-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-2473224:r:Antagonism of Activin by Follistatin", "R-BTA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-201451:r:Signaling by BMP", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-RNO-3000170:r:Syndecan interactions", "R-RNO-201451:r:Signaling by BMP", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-8941855:r:RUNX3 regulates CDKN1A transcription", "R-SSC-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-1502540:r:Signaling by Activin", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-BTA-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-209822:r:Glycoprotein hormones", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-SSC-209822:r:Glycoprotein hormones", "R-DME-3000170:r:Syndecan interactions", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-MMU-209822:r:Glycoprotein hormones", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-9761174:r:Formation of intermediate mesoderm", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-2473224:r:Antagonism of Activin by Follistatin", "R-SSC-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR001114": {"description": "Adenylosuccinate synthetase", "go_ids": ["GO:0004019", "GO:0006164", "GO:0000166"], "go_terms": ["GO:0004019:adenylosuccinate synthase activity:F", "GO:0006164:purine nucleotide biosynthetic process:P", "GO:0000166:nucleotide binding:F"], "name": "Adenylosuccinate_synthetase", "pathway_ids": ["PWY-7219", "R-SPO-73817", "R-XTR-73817", "R-DDI-73817", "R-GGA-421203", "R-DME-73817", "R-BTA-73817", "R-MMU-73817", "R-SCE-73817", "R-CEL-73817", "R-SSC-73817", "R-HSA-73817", "R-PFA-73817", "R-DRE-73817"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-XTR-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-421203:r:De novo synthesis of AMP", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SSC-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DRE-73817:r:Purine ribonucleoside monophosphate biosynthesis"], "type": "Family"}, "IPR001117": {"description": "Multicopper oxidase, second cupredoxin domain", "go_ids": [], "go_terms": [], "name": "Cu-oxidase_2nd", "pathway_ids": ["R-RNO-381426", "R-MMU-917937", "R-HSA-5619060", "R-RNO-425410", "R-RNO-8957275", "R-HSA-917937", "R-RNO-917937", "R-MMU-381426", "R-HSA-425410", "R-HSA-8957275", "R-MMU-425410", "R-HSA-5619049", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-917937:r:Iron uptake and transport", "R-HSA-5619060:r:Defective CP causes aceruloplasminemia (ACERULOP)", "R-RNO-425410:r:Metal ion SLC transporters", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-917937:r:Iron uptake and transport", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-425410:r:Metal ion SLC transporters", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-425410:r:Metal ion SLC transporters", "R-HSA-5619049:r:Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR001119": {"description": "S-layer homology domain", "go_ids": [], "go_terms": [], "name": "SLH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001122": {"description": "Capsid protein C, flavivirus", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Flavi_capsidC", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR001123": {"description": "Amino acid exporter protein, LeuE-type", "go_ids": ["GO:0006865", "GO:0016020"], "go_terms": ["GO:0006865:amino acid transport:P", "GO:0016020:membrane:C"], "name": "LeuE-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001124": {"description": "Lipid-binding serum glycoprotein, C-terminal", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "Lipid-bd_serum_glycop_C", "pathway_ids": ["R-RNO-5686938", "R-HSA-6798695", "R-DDI-6798695", "R-RNO-6798695", "R-RNO-6803157", "R-BTA-6803157", "R-HSA-8964058", "R-DDI-166016", "R-HSA-166016", "R-MMU-166016", "R-BTA-6798695", "R-CEL-5686938", "R-HSA-6785807", "R-MMU-5686938", "R-HSA-8964041", "R-MMU-8957275", "R-MMU-166020", "R-BTA-166016", "R-HSA-381426", "R-HSA-166020", "R-MMU-381426", "R-HSA-6803157", "R-DDI-6803157", "R-MMU-6798695", "R-CEL-166016", "R-MMU-6803157", "R-HSA-8957275", "R-HSA-5686938", "R-RNO-166016", "R-HSA-9029569", "R-MMU-8964058", "R-RNO-166020", "R-DDI-5686938"], "pathways": ["R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-6803157:r:Antimicrobial peptides", "R-HSA-8964058:r:HDL remodeling", "R-DDI-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-166020:r:Transfer of LPS from LBP carrier to CD14", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-166020:r:Transfer of LPS from LBP carrier to CD14", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-DDI-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-8964058:r:HDL remodeling", "R-RNO-166020:r:Transfer of LPS from LBP carrier to CD14", "R-DDI-5686938:r:Regulation of TLR by endogenous ligand"], "type": "Domain"}, "IPR001126": {"description": "UmuC domain", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "UmuC", "pathway_ids": ["R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656121", "R-SPO-5656169", "R-SPO-5655862", "R-HSA-5696397", "R-MMU-110320", "R-MMU-110312", "R-SPO-110312", "R-DME-5656121", "R-GGA-5655862", "R-HSA-5655862", "R-GGA-353503", "R-DME-5655862", "R-DME-110312", "R-HSA-6782210", "R-HSA-5656169", "R-HSA-5656121", "R-MMU-5696400", "R-MMU-5655862", "R-GGA-5656121", "R-DME-110320", "R-CEL-5655862", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-CEL-6782210", "R-HSA-110312", "R-CEL-5696397", "R-GGA-110312", "R-GGA-5656169", "R-MMU-5656121", "R-SPO-5696400", "R-SPO-110320", "R-CEL-6782135", "R-HSA-5696400", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-HSA-110320"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-DME-5656121:r:Translesion synthesis by POLI", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-GGA-353503:r:Translesion synthesis by Pol kappa", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-DME-110320:r:Translesion Synthesis by POLH", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110312:r:Translesion synthesis by REV1", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-110320:r:Translesion Synthesis by POLH"], "type": "Domain"}, "IPR001127": {"description": "Phosphotransferase system, sugar-specific permease EIIA type 1", "go_ids": ["GO:0009401"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PTS_EIIA_1_perm", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001128": {"description": "Cytochrome P450", "go_ids": ["GO:0004497", "GO:0005506", "GO:0020037", "GO:0016705"], "go_terms": ["GO:0004497:monooxygenase activity:F", "GO:0005506:iron ion binding:F", "GO:0020037:heme binding:F", "GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F"], "name": "Cyt_P450", "pathway_ids": ["R-DRE-6807047", "R-RNO-193807", "R-DRE-211976", "R-SSC-2162123", "R-MMU-9753281", "R-DRE-211979", "R-CEL-211945", "R-RNO-9753281", "R-RNO-211957", "R-RNO-5423646", "R-DRE-211916", "R-HSA-211979", "R-MMU-5423646", "R-SSC-193807", "R-HSA-6807047", "R-CFA-211945", "R-HSA-211994", "R-DME-2453902", "R-DDI-211976", "R-HSA-193048", "R-CFA-9757110", "R-BTA-211999", "R-CEL-193144", "R-BTA-193993", "R-HSA-2453902", "R-RNO-193144", "R-MMU-2142816", "R-HSA-196108", "R-SSC-193144", "R-RNO-2142816", "R-HSA-193775", "R-HSA-5579032", "R-DME-193144", "R-CEL-211916", "R-HSA-5579026", "R-HSA-5365859", "R-HSA-192105", "R-MMU-156581", "R-HSA-211999", "R-BTA-193048", "R-RNO-211945", "R-RNO-193775", "R-SSC-2142816", "R-DRE-2162123", "R-MMU-211976", "R-HSA-9749641", "R-SSC-211935", "R-MMU-211999", "R-DRE-5365859", "R-RNO-6807047", "R-MMU-9757110", "R-MMU-193807", "R-BTA-5365859", "R-CEL-5423646", "R-HSA-211945", "R-DDI-9749641", "R-CFA-9753281", "R-MMU-193775", "R-CEL-9027307", "R-MMU-211935", "R-DDI-2142670", "R-HSA-193368", "R-RNO-193993", "R-BTA-211979", "R-HSA-5579013", "R-RNO-193048", "R-RNO-9757110", "R-MMU-196108", "R-HSA-196791", "R-DME-196791", "R-DDI-211981", "R-DME-2142816", "R-HSA-5579011", "R-HSA-9027307", "R-RNO-211958", "R-BTA-9749641", "R-SSC-194002", "R-MMU-211994", "R-RNO-211935", "R-MMU-193368", "R-MMU-2162123", "R-CFA-9754706", "R-DME-211958", "R-MMU-2142670", "R-SSC-211958", "R-BTA-211958", "R-RNO-2453902", "R-CEL-9749641", "R-RNO-9027307", "R-HSA-6807062", "R-MMU-193993", "R-MMU-211979", "R-HSA-5579028", "R-HSA-211958", "R-BTA-9027307", "R-HSA-5579030", "R-RNO-9018681", "R-HSA-193144", "R-SSC-192105", "R-DDI-211999", "R-HSA-5579005", "R-HSA-5579027", "R-HSA-2426168", "R-DDI-196791", "R-HSA-2142816", "R-HSA-1989781", "R-HSA-211981", "R-HSA-2142691", "R-CEL-2142670", "R-SSC-193368", "R-XTR-211916", "R-DRE-193144", "R-DME-211916", "R-HSA-5423646", "R-BTA-211976", "R-DDI-2142816", "R-DDI-211958", "R-RNO-211981", "R-HSA-5579009", "R-SSC-2142691", "R-SPO-211976", "R-BTA-2162123", "R-DME-2142691", 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"R-RNO-9754706", "R-HSA-193993", "R-HSA-5579017", "R-MMU-194002", "R-HSA-5579000", "R-HSA-5578996", "R-CEL-2142816", "R-MMU-211958", "R-DDI-211945", "R-HSA-211916", "R-HSA-2142670", "R-HSA-5579014", "R-CEL-211981", "R-HSA-2162123", "R-CEL-211976", "R-BTA-211981", "R-HSA-9753281", "R-DDI-211935", "R-RNO-194002", "R-RNO-196108", "R-SSC-193048", "R-XTR-5365859", "R-DME-211935", "R-RNO-2142691", "R-CFA-211981", "R-CFA-9749641", "R-SSC-211979", "R-SCE-6807047", "R-MMU-211916", "R-RNO-2142670", "R-RNO-9749641", "R-HSA-156581", "R-MMU-193144", "R-HSA-211935", "R-DDI-9753281", "R-HSA-194002"], "pathways": ["R-DRE-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DRE-211976:r:Endogenous sterols", "R-SSC-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-9753281:r:Paracetamol ADME", "R-DRE-211979:r:Eicosanoids", "R-CEL-211945:r:Phase I - Functionalization of compounds", 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"R-SSC-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-GGA-1502540:r:Signaling by Activin", "R-CEL-1502540:r:Signaling by Activin", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SSC-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-SSC-201451:r:Signaling by BMP", "R-HSA-1181150:r:Signaling by NODAL", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-GGA-1181150:r:Signaling by NODAL", "R-SSC-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-201451:r:Signaling by BMP", "R-CEL-8941855:r:RUNX3 regulates CDKN1A transcription", "R-SSC-5689880:r:Ub-specific 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development", "R-CEL-201451:r:Signaling by BMP", "R-GGA-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-RNO-1181150:r:Signaling by NODAL", "R-HSA-877300:r:Interferon gamma signaling", "R-DME-1181150:r:Signaling by NODAL", "R-HSA-9733709:r:Cardiogenesis", "R-DRE-1502540:r:Signaling by Activin", "R-DME-8941326:r:RUNX2 regulates bone development", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-SSC-8941326:r:RUNX2 regulates bone development"], "type": "Domain"}, "IPR001133": {"description": "NADH-ubiquinone oxidoreductase chain 4L/K", "go_ids": ["GO:0016651", "GO:0042773"], "go_terms": ["GO:0016651:oxidoreductase activity, acting on NAD(P)H:F", "GO:0042773:ATP synthesis 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"R-HSA-72764:r:Eukaryotic Translation Termination", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001142": {"description": "Yeast membrane protein DUP/COS", "go_ids": [], "go_terms": [], "name": "DUP/COS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001144": {"description": "Heat-labile enterotoxin, A chain", "go_ids": ["GO:0090729", "GO:0005576"], "go_terms": ["GO:0090729:toxin activity:F", "GO:0005576:extracellular region:C"], "name": "Enterotoxin_A", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR001147": {"description": "Large ribosomal subunit protein eL21", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL21", "pathway_ids": ["R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-SPO-9954709", "R-HSA-1799339", "R-MMU-6791226", "R-SPO-975956", "R-HSA-2408557", "R-MMU-9954714", "R-SPO-72706", "R-SSC-9954714", "R-CEL-1799339", "R-SCE-975956", "R-HSA-72706", "R-CEL-156827", "R-SSC-1799339", "R-SSC-975957", "R-HSA-6791226", "R-SSC-72689", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-MMU-72689", "R-SCE-72706", "R-HSA-156827", "R-MMU-9954709", "R-HSA-192823", "R-SSC-9954716", "R-SSC-156827", "R-SCE-975957", "R-HSA-9954709", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SSC-9954709", "R-SCE-9954714", "R-MMU-156827", "R-HSA-975957", "R-SSC-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DDI-156827", "R-DDI-9954716", "R-HSA-9633012"], "pathways": ["R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001148": {"description": "Alpha carbonic anhydrase domain", "go_ids": [], "go_terms": [], "name": "CA_dom", "pathway_ids": ["PWY-5743", "PWY-5789", "PWY-7115", "PWY-6142", "PWY-7117", "PWY-241", "PWY-5744", "R-HSA-9925563", "R-HSA-449836", "R-GGA-1475029", "R-MMU-1237044", "R-RNO-1237044", "R-HSA-1247673", "R-RNO-1247673", "R-BTA-1475029", "R-HSA-1234158", "R-RNO-9851151", "R-MMU-1247673", "R-GGA-1247673", "R-HSA-8950505", "R-HSA-1237044", "R-DRE-1247673", "R-BTA-1247673", "R-GGA-1237044", "R-MMU-449836", "R-HSA-1475029", "R-MMU-1475029", "R-HSA-9851151", "R-CEL-1237044", "R-DRE-1237044", "R-MMU-9851151", "R-CEL-1475029", "R-DRE-1475029", "R-BTA-1237044", "R-CEL-1247673", "R-RNO-449836", "R-RNO-1475029"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-241:t:C4 photosynthetic carbon assimilation cycle, NADP-ME type", "PWY-5744:t:glyoxylate assimilation", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-449836:r:Other interleukin signaling", "R-GGA-1475029:r:Reversible hydration of carbon dioxide", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-1475029:r:Reversible hydration of carbon dioxide", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-GGA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DRE-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-GGA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-1475029:r:Reversible hydration of carbon dioxide", "R-MMU-1475029:r:Reversible hydration of carbon dioxide", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-CEL-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DRE-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-CEL-1475029:r:Reversible hydration of carbon dioxide", "R-DRE-1475029:r:Reversible hydration of carbon dioxide", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-CEL-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-449836:r:Other interleukin signaling", "R-RNO-1475029:r:Reversible hydration of carbon dioxide"], "type": "Domain"}, "IPR001150": {"description": "Glycine radical domain", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Gly_radical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001152": {"description": "Beta-thymosin", "go_ids": ["GO:0003785", "GO:0007015"], "go_terms": ["GO:0003785:actin monomer binding:F", "GO:0007015:actin filament organization:P"], "name": "Beta-thymosin", "pathway_ids": ["R-HSA-114608", "R-RNO-114608", "R-MMU-114608", "R-SSC-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation", "R-SSC-114608:r:Platelet degranulation"], "type": "Family"}, "IPR001153": {"description": "Barwin domain", "go_ids": ["GO:0042742", "GO:0050832"], "go_terms": ["GO:0042742:defense response to bacterium:P", "GO:0050832:defense response to fungus:P"], "name": "Barwin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001155": {"description": "NADH:flavin oxidoreductase/NADH oxidase, N-terminal", "go_ids": ["GO:0010181", "GO:0016491"], "go_terms": ["GO:0010181:FMN binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "OxRdtase_FMN_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001156": {"description": "Transferrin-like domain", "go_ids": [], "go_terms": [], "name": "Transferrin-like_dom", "pathway_ids": ["R-HSA-6798695", "R-MMU-8856828", "R-MMU-163125", "R-DME-381426", "R-BTA-6803157", "R-DME-8957275", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-6799990", "R-HSA-977225", "R-BTA-6798695", "R-HSA-1222449", "R-MMU-8957275", "R-RNO-114608", "R-HSA-114608", "R-MMU-917937", "R-RNO-8957275", "R-HSA-6799990", "R-MMU-381426", "R-HSA-6803157", "R-RNO-8856828", "R-MMU-6803157", "R-DME-917937", "R-RNO-917977", "R-HSA-381426", "R-DRE-8957275", "R-RNO-8856825", "R-BTA-6799990", "R-RNO-917937", "R-DME-6798695", "R-DME-114608", "R-HSA-163125", "R-RNO-381426", "R-HSA-8856825", "R-MMU-917977", "R-HSA-917937", "R-DRE-381426", "R-MMU-6798695", "R-HSA-8957275", "R-DME-6799990", "R-HSA-917977", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-6803157:r:Antimicrobial peptides", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-6799990:r:Metal sequestration by antimicrobial proteins", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-MMU-917937:r:Iron uptake and transport", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-6799990:r:Metal sequestration by antimicrobial proteins", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-6803157:r:Antimicrobial peptides", "R-DME-917937:r:Iron 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novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR001158": {"description": "DIX domain", "go_ids": [], "go_terms": [], "name": "DIX", "pathway_ids": ["R-RNO-201681", "R-MMU-8856828", "R-DME-209155", "R-HSA-8939256", "R-HSA-8856828", "R-HSA-5689880", "R-XTR-8856825", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-195253", "R-XTR-4641262", "R-DME-4086400", "R-DME-350376", "R-MMU-5689880", "R-DME-5099900", "R-CEL-4641257", "R-HSA-5358747", "R-RNO-196299", "R-DME-350411", "R-DME-4641262", "R-DRE-4641262", "R-HSA-4641257", "R-HSA-5467337", "R-XTR-5099900", "R-DME-5663220", "R-DME-4608870", "R-HSA-9018519", "R-DME-209413", "R-HSA-5358752", "R-RNO-4641258", "R-HSA-5358749", "R-HSA-8931987", "R-MMU-196299", "R-CEL-4641258", "R-DME-350369", "R-DME-4641257", "R-RNO-4086400", "R-DME-209461", "R-MMU-4086400", "R-CEL-4086400", "R-MMU-201681", "R-XTR-4641258", "R-RNO-5663220", "R-HSA-4641258", "R-HSA-5467340", "R-RNO-5689880", "R-DRE-196299", "R-MMU-4641258", "R-HSA-4608870", "R-XTR-4086400", "R-MMU-4641257", "R-MMU-4641262", "R-CEL-8856825", "R-MMU-5663220", "R-XTR-2028269", "R-RNO-201688", "R-HSA-5358751", "R-HSA-201681", "R-DME-432553", "R-RNO-4641262", "R-DRE-195253", "R-CEL-5663220", "R-MMU-8856825", "R-HSA-5368598", "R-HSA-5467348", "R-DME-4641258", "R-DME-350368", "R-MMU-201688", "R-DRE-4641257", "R-DME-2028269", "R-DME-195253", "R-HSA-196299", "R-DME-209214", "R-RNO-4641257", "R-DME-209396", "R-HSA-5339716", "R-HSA-4641262", "R-MMU-4608870", "R-DME-450728", "R-MMU-195253", "R-HSA-195253", "R-XTR-8856828", "R-CEL-8856828", "R-DME-209190", "R-DME-209360", "R-HSA-201688", "R-MMU-2028269", "R-HSA-4086400", "R-XTR-201688", "R-HSA-5099900", "R-XTR-5663220", "R-DME-350480", "R-DME-196299", "R-HSA-9673324", "R-DME-201688", "R-CEL-2028269", "R-CEL-201688", "R-CEL-196299", "R-DME-209440", "R-HSA-8856825", "R-HSA-5663220", "R-HSA-4411364", "R-RNO-195253", "R-HSA-2028269"], "pathways": ["R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5689880:r:Ub-specific processing proteases", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-4086400:r:PCP/CE pathway", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-4641257:r:Degradation of AXIN", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-4641258:r:Degradation of DVL", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-DME-4641257:r:Degradation of AXIN", "R-RNO-4086400:r:PCP/CE pathway", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-4086400:r:PCP/CE pathway", "R-CEL-4086400:r:PCP/CE pathway", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-XTR-4641258:r:Degradation of DVL", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-XTR-4086400:r:PCP/CE pathway", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-XTR-2028269:r:Signaling by Hippo", "R-RNO-201688:r:WNT mediated activation of DVL", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-DME-4641258:r:Degradation of DVL", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-MMU-201688:r:WNT mediated activation of DVL", "R-DRE-4641257:r:Degradation of AXIN", "R-DME-2028269:r:Signaling by Hippo", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-DME-209214:r:Phosphorylation of SMO", "R-RNO-4641257:r:Degradation of AXIN", "R-DME-209396:r:Phosphorylation of ARM", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DME-209190:r:Phosphorylation of CI", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-HSA-201688:r:WNT mediated activation of DVL", "R-MMU-2028269:r:Signaling by Hippo", "R-HSA-4086400:r:PCP/CE pathway", "R-XTR-201688:r:WNT mediated activation of DVL", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-DME-201688:r:WNT mediated activation of DVL", "R-CEL-2028269:r:Signaling by Hippo", "R-CEL-201688:r:WNT mediated activation of DVL", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-2028269:r:Signaling by Hippo"], "type": "Domain"}, "IPR001160": {"description": "Peptidase M20C, Xaa-His dipeptidase", "go_ids": ["GO:0006508"], "go_terms": ["GO:0006508:proteolysis:P"], "name": "Peptidase_M20C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001161": {"description": "Helicase XPB/Ssl2", "go_ids": ["GO:0003678", "GO:0006289", "GO:0006367"], "go_terms": ["GO:0003678:DNA helicase activity:F", "GO:0006289:nucleotide-excision repair:P", "GO:0006367:transcription initiation at RNA polymerase II promoter:P"], "name": "XPB/Ssl2", "pathway_ids": ["R-DDI-75953", "R-SPO-6782135", 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"R-DME-113418", "R-RNO-113418", "R-MMU-6796648", "R-RNO-6796648", "R-DRE-73772", "R-RNO-75955", "R-SCE-6781823", "R-DME-5696395", "R-BTA-674695", "R-DRE-73776", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-DRE-6782135", "R-MMU-77075", "R-HSA-75955", "R-DME-5696400", "R-SPO-6782210", "R-RNO-5696400", "R-HSA-5696400", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-SCE-73772", "R-HSA-112382", "R-HSA-73779", "R-RNO-674695", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-DRE-73779", "R-BTA-76042", "R-RNO-73863", "R-DRE-75953", "R-HSA-6796648", "R-HSA-6781823", "R-SPO-5696395", "R-HSA-167246", "R-MMU-5696395", "R-DRE-6796648", "R-DRE-113418", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-RNO-6782210", "R-SPO-113418", "R-DDI-73779", "R-DME-674695", "R-BTA-72086", "R-RNO-76042", "R-DDI-6781823", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-SCE-76042", "R-HSA-167200", "R-RNO-112382", "R-SCE-674695", "R-MMU-6782210", 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Complex in GG-NER", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72086:r:mRNA Capping", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE"], "type": "Family"}, "IPR001162": {"description": "UvrC, RNAse H endonuclease domain", "go_ids": ["GO:0009381"], "go_terms": ["GO:0009381:excinuclease ABC activity:F"], "name": "UvrC_RNase_H_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001163": {"description": "Sm domain, eukaryotic/archaea-type", "go_ids": [], "go_terms": [], "name": "Sm_dom_euk/arc", "pathway_ids": ["R-MMU-77588", "R-CEL-72165", "R-MMU-9770562", "R-GGA-73856", "R-HSA-73856", "R-DME-72163", "R-RNO-72163", "R-DDI-72163", "R-RNO-73856", "R-BTA-430039", "R-RNO-191859", "R-MMU-430039", "R-RNO-72165", "R-CEL-9770562", "R-DME-73856", "R-HSA-430039", "R-SPO-430039", "R-BTA-72163", "R-MMU-72163", "R-MMU-73856", "R-BTA-73856", "R-GGA-111367", "R-SPO-9770562", "R-HSA-72163", "R-DME-72165", "R-MMU-111367", "R-BTA-9770562", "R-DME-77588", "R-GGA-191859", "R-CEL-77588", "R-DME-111367", "R-GGA-77588", "R-BTA-191859", "R-CEL-111367", "R-HSA-191859", "R-CEL-191859", "R-BTA-77588", "R-DDI-9770562", "R-CEL-73856", "R-DDI-111367", "R-HSA-6811440", "R-DRE-191859", "R-DME-9770562", "R-DDI-73856", "R-DRE-72163", "R-GGA-72163", "R-DRE-9770562", "R-HSA-77588", "R-HSA-111367", "R-HSA-72165", "R-GGA-9770562", "R-CEL-72163", "R-CEL-430039", "R-HSA-9918481", "R-MMU-191859", "R-DDI-430039", "R-BTA-111367", "R-GGA-72165", "R-HSA-9770562", "R-BTA-72165", "R-SCE-430039", "R-HSA-9754678", "R-RNO-111367", "R-MMU-72165", "R-DDI-77588", "R-DRE-430039", "R-RNO-9770562", "R-RNO-77588", "R-SPO-72163", "R-DRE-72165"], "pathways": ["R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", 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Polymerase II Transcription Termination", "R-GGA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-BTA-9770562:r:mRNA Polyadenylation", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-GGA-191859:r:snRNP Assembly", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DME-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-GGA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-BTA-191859:r:snRNP Assembly", "R-CEL-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-191859:r:snRNP Assembly", "R-CEL-191859:r:snRNP Assembly", "R-BTA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DRE-191859:r:snRNP Assembly", "R-DME-9770562:r:mRNA Polyadenylation", "R-DDI-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-GGA-9770562:r:mRNA Polyadenylation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-191859:r:snRNP Assembly", "R-DDI-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-BTA-111367:r:SLBP independent Processing of 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"R-MMU-8856828", "R-HSA-8849469", "R-HSA-8856828", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-6811434", "R-MMU-9013420", "R-RNO-9013424", "R-DME-3928664", "R-RNO-9013408", "R-RNO-9013404", "R-RNO-9013406", "R-HSA-9013408", "R-DDI-193648", "R-MMU-6811434", "R-DME-9013149", "R-MMU-5620916", "R-SCE-6811434", "R-HSA-3928664", "R-RNO-5620916", "R-CEL-6807878", "R-HSA-373752", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013406", "R-SPO-6811434", "R-RNO-9013420", "R-BTA-6811434", "R-MMU-8980692", "R-HSA-1251985", "R-MMU-9013148", "R-DME-9013424", "R-MMU-6807878", "R-DDI-9013149", "R-HSA-9013423", "R-BTA-6807878", "R-HSA-5620916", "R-DME-5620916", "R-HSA-9013148", "R-DME-9013406", "R-HSA-9619229", "R-RNO-8856828", "R-DME-9013423", "R-MMU-3928664", "R-HSA-381038", "R-HSA-9013420", "R-SCE-6807878", "R-RNO-6811434", "R-RNO-8856825", "R-MMU-8849469", "R-RNO-6807878", "R-HSA-6807878", "R-MMU-9013424", "R-RNO-3928664", "R-RNO-9013423", 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cycle", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-9013420:r:RHOU GTPase cycle", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-9013420:r:RHOU GTPase cycle", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-3928664:r:Ephrin signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR001171": {"description": "Sterol biosynthesis ERG24/DHCR-like", "go_ids": ["GO:0016126", "GO:0016628", "GO:0016020"], "go_terms": ["GO:0016126:sterol biosynthetic process:P", "GO:0016628:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor:F", "GO:0016020:membrane:C"], "name": "ERG24_DHCR-like", "pathway_ids": ["R-HSA-9013405", "R-DRE-6807047", "R-SPO-6807047", "R-RNO-2995383", "R-HSA-9022692", "R-MMU-9013106", "R-DRE-9969901", "R-SPO-2995383", "R-MMU-8980692", "R-DME-2995383", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9969901", "R-HSA-9013106", "R-MMU-9013148", "R-MMU-9013404", "R-SCE-2995383", "R-HSA-9013423", "R-HSA-6807047", "R-MMU-6807047", "R-MMU-9022692", "R-HSA-9013148", "R-RNO-9013404", "R-RNO-9013106", "R-RNO-9013408", "R-HSA-9013408", "R-SPO-6807062", "R-DME-6807047", "R-MMU-6807062", "R-MMU-2995383", "R-XTR-6807047", "R-SCE-6807062", "R-HSA-9969901", "R-RNO-9022692", "R-HSA-2995383", "R-RNO-9013148", "R-HSA-6807062", "R-SCE-9013106", "R-RNO-9969901", "R-BTA-6807047", "R-RNO-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-SCE-6807047", "R-BTA-9969901", "R-MMU-9013149", "R-RNO-6807047", "R-XTR-9969901", "R-HSA-2426168"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-DRE-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-SPO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-9013106:r:RHOC GTPase cycle", "R-DRE-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-SPO-2995383:r:Initiation of Nuclear Envelope (NE) 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(Kandutsch-Russell pathway)", "R-DME-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-XTR-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-SCE-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-HSA-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-RNO-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-BTA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-BTA-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-XTR-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Family"}, "IPR001173": {"description": "Glycosyltransferase 2-like", "go_ids": [], "go_terms": [], "name": "Glyco_trans_2-like", "pathway_ids": ["R-DRE-913709", "R-HSA-9694719", "R-MMU-913709", "R-HSA-4719377", "R-DDI-162699", "R-SCE-480985", "R-HSA-4719360", "R-HSA-9037629", "R-HSA-5083625", "R-SPO-162699", "R-DME-190372", "R-DDI-480985", "R-RNO-913709", "R-MMU-480985", "R-BTA-913709", "R-HSA-190372", "R-HSA-6811436", "R-MMU-446203", "R-SSC-162699", "R-DME-162699", "R-HSA-162699", "R-HSA-5083636", "R-DME-6811436", "R-HSA-446203", "R-SPO-480985", "R-HSA-9918432", "R-CEL-6811436", "R-MMU-190372", "R-MMU-2142845", "R-DME-480985", "R-MMU-6811436", "R-MMU-162699", "R-RNO-6811436", "R-BTA-6811436", "R-HSA-9840309", "R-HSA-480985", "R-RNO-9840309", "R-CEL-913709", "R-MMU-9840309", "R-HSA-9931953", "R-HSA-9683673", "R-XTR-913709", "R-DME-913709", "R-HSA-4717374", "R-MMU-9037629", "R-HSA-913709"], "pathways": ["R-DRE-913709:r:O-linked glycosylation of mucins", "R-HSA-9694719:r:Maturation of protein 3a", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-4719377:r:Defective DPM2 causes DPM2-CDG", "R-DDI-162699:r:Synthesis of dolichyl-phosphate mannose", "R-SCE-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-HSA-4719360:r:Defective DPM3 causes DPM3-CDG", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-SPO-162699:r:Synthesis of dolichyl-phosphate mannose", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-DDI-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-MMU-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-BTA-913709:r:O-linked glycosylation of mucins", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-SSC-162699:r:Synthesis of dolichyl-phosphate mannose", "R-DME-162699:r:Synthesis of dolichyl-phosphate mannose", "R-HSA-162699:r:Synthesis of dolichyl-phosphate mannose", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-SPO-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-DME-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-162699:r:Synthesis of dolichyl-phosphate mannose", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-9931953:r:Biofilm formation", "R-HSA-9683673:r:Maturation of protein 3a", "R-XTR-913709:r:O-linked glycosylation of mucins", "R-DME-913709:r:O-linked glycosylation of mucins", "R-HSA-4717374:r:Defective DPM1 causes DPM1-CDG", "R-MMU-9037629:r:Lewis blood group biosynthesis", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Domain"}, "IPR001177": {"description": "DNA helicase E1, C-terminal, Papillomavirus", "go_ids": ["GO:0003677", "GO:0003678", "GO:0005524", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003678:DNA helicase activity:F", "GO:0005524:ATP binding:F", "GO:0006260:DNA replication:P"], "name": "PPV_DNA_helicase_E1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001178": {"description": "Pesticidal crystal protein, domain II", "go_ids": ["GO:0005102"], "go_terms": ["GO:0005102:signaling receptor binding:F"], "name": "Pest_cryst_dom_II", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001179": {"description": "FKBP-type peptidyl-prolyl cis-trans isomerase domain", "go_ids": ["GO:0003755"], "go_terms": ["GO:0003755:peptidyl-prolyl cis-trans isomerase activity:F"], "name": "PPIase_FKBP_dom", "pathway_ids": ["R-DME-2173789", "R-MMU-9909505", "R-HSA-168188", "R-HSA-3656535", "R-HSA-5689880", "R-DME-3371497", "R-HSA-2672351", "R-DME-2025928", "R-RNO-3371497", "R-RNO-9909505", "R-HSA-3371497", "R-SPO-166208", "R-HSA-1221632", "R-BTA-2173789", "R-SCE-2025928", "R-RNO-9018519", "R-HSA-9909505", "R-RNO-166208", "R-BTA-2672351", "R-MMU-5689880", "R-HSA-2025928", "R-RNO-2672351", "R-HSA-166208", "R-RNO-3371568", "R-MMU-2672351", "R-RNO-2025928", "R-HSA-8939211", "R-DME-166208", "R-BTA-5578775", "R-HSA-5578775", "R-SPO-2025928", "R-SCE-166208", "R-HSA-3371568", "R-HSA-9018519", "R-RNO-2173789", "R-HSA-2173789", "R-HSA-8937144", "R-HSA-5601884", "R-PFA-3371497", "R-HSA-381038", "R-MMU-8939211", "R-HSA-166058", "R-MMU-2173789", "R-HSA-390471", "R-BTA-166208", "R-HSA-2173791", "R-DME-9018519", "R-RNO-5578775", "R-DDI-166208", "R-MMU-5578775", "R-HSA-8950505", "R-HSA-9760173", "R-HSA-9679191", "R-RNO-5689880", "R-MMU-9018519", "R-DME-9909505", "R-DME-3371568", "R-MMU-3371568", "R-HSA-9692916", "R-MMU-166208", "R-MMU-2025928", "R-HSA-9022699", "R-HSA-1236974", "R-HSA-5602498", "R-HSA-5603041", "R-DME-8939211", "R-BTA-2025928", "R-RNO-8939211", "R-MMU-3371497", "R-DDI-2025928"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-168188:r:Toll Like Receptor TLR6:TLR2 Cascade", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-2672351:r:Stimuli-sensing channels", "R-DME-2025928:r:Calcineurin activates NFAT", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-166208:r:mTORC1-mediated signalling", "R-HSA-1221632:r:Meiotic synapsis", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SCE-2025928:r:Calcineurin activates NFAT", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-166208:r:mTORC1-mediated signalling", "R-BTA-2672351:r:Stimuli-sensing channels", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-166208:r:mTORC1-mediated signalling", "R-RNO-3371568:r:Attenuation phase", "R-MMU-2672351:r:Stimuli-sensing channels", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-HSA-8939211:r:ESR-mediated signaling", "R-DME-166208:r:mTORC1-mediated signalling", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-SPO-2025928:r:Calcineurin activates NFAT", "R-SCE-166208:r:mTORC1-mediated signalling", "R-HSA-3371568:r:Attenuation phase", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-8939211:r:ESR-mediated signaling", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-BTA-166208:r:mTORC1-mediated signalling", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-RNO-5578775:r:Ion homeostasis", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DME-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-3371568:r:Attenuation phase", "R-MMU-3371568:r:Attenuation phase", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-166208:r:mTORC1-mediated signalling", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-DME-8939211:r:ESR-mediated signaling", "R-BTA-2025928:r:Calcineurin activates NFAT", "R-RNO-8939211:r:ESR-mediated signaling", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DDI-2025928:r:Calcineurin activates NFAT"], "type": "Domain"}, "IPR001180": {"description": "Citron homology (CNH) domain", "go_ids": [], "go_terms": [], "name": "CNH_dom", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-DME-9013149", "R-HSA-5625900", "R-HSA-2559580", "R-MMU-9013106", "R-MMU-8980692", "R-MMU-5625900", "R-RNO-8980692", "R-DDI-392517", "R-RNO-9013149", "R-HSA-9013106", "R-CEL-2559580", "R-MMU-2559580", "R-CEL-9013149", "R-RNO-5625900", "R-HSA-9754560", "R-HSA-9013149", "R-RNO-2559580", "R-HSA-8980692", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9013148", "R-DME-9013406", "R-CEL-9013406", "R-HSA-9013026", "R-RNO-9013106", "R-RNO-9013406", "R-HSA-9013406", "R-MMU-9013149"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-RNO-8980692:r:RHOA GTPase cycle", "R-DDI-392517:r:Rap1 signalling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR001181": {"description": "Interleukin-7", "go_ids": ["GO:0005139", "GO:0005576", "GO:0006955", "GO:0008083"], "go_terms": ["GO:0005139:interleukin-7 receptor binding:F", "GO:0005576:extracellular region:C", "GO:0006955:immune response:P", "GO:0008083:growth factor activity:F"], "name": "IL-7", "pathway_ids": ["R-BTA-1266695", "R-SSC-1266695", "R-RNO-1266695", "R-MMU-1266695", "R-HSA-1266695"], "pathways": ["R-BTA-1266695:r:Interleukin-7 signaling", "R-SSC-1266695:r:Interleukin-7 signaling", "R-RNO-1266695:r:Interleukin-7 signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-1266695:r:Interleukin-7 signaling"], "type": "Family"}, "IPR001182": {"description": "Probable peptidoglycan glycosyltransferase FtsW/RodA", "go_ids": ["GO:0016020", "GO:0051301"], "go_terms": ["GO:0016020:membrane:C", "GO:0051301:cell division:P"], "name": "FtsW/RodA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001185": {"description": "Large-conductance mechanosensitive channel", "go_ids": ["GO:0016020", "GO:0034220", "GO:0008381"], "go_terms": ["GO:0016020:membrane:C", "GO:0034220:monoatomic ion transmembrane transport:P", "GO:0008381:mechanosensitive monoatomic ion channel activity:F"], "name": "MS_channel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001187": {"description": "Tissue factor", "go_ids": ["GO:0007596", "GO:0016020"], "go_terms": ["GO:0007596:blood coagulation:P", "GO:0016020:membrane:C"], "name": "Tissue_factor", "pathway_ids": ["R-MMU-140834", "R-HSA-140834", "R-HSA-9031628", "R-RNO-140834", "R-BTA-140834"], "pathways": ["R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-9031628:r:NGF-stimulated transcription", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation"], "type": "Family"}, "IPR001188": {"description": "Spermidine/putrescine-binding periplasmic protein", "go_ids": ["GO:0015846", "GO:0019808", "GO:0042597"], "go_terms": ["GO:0015846:polyamine transport:P", "GO:0019808:polyamine binding:F", "GO:0042597:periplasmic space:C"], "name": "Sperm_putr-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001189": {"description": "Manganese/iron superoxide dismutase", "go_ids": ["GO:0004784", "GO:0006801", "GO:0046872"], "go_terms": ["GO:0004784:superoxide dismutase activity:F", "GO:0006801:superoxide metabolic process:P", "GO:0046872:metal ion binding:F"], "name": "Mn/Fe_SOD", "pathway_ids": ["PWY-6854", "R-DDI-3299685", "R-HSA-3299685", "R-SCE-3299685", "R-HSA-9615017", "R-HSA-2151201", "R-SPO-3299685", "R-RNO-3299685", "R-RNO-2151201", "R-HSA-9841251", "R-HSA-8950505", "R-HSA-8862803", "R-HSA-1222387", "R-CEL-3299685", "R-DME-3299685", "R-MMU-3299685", "R-MMU-2151201"], "pathways": ["PWY-6854:t:ethene biosynthesis III (microbes)", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis"], "type": "Family"}, "IPR001190": {"description": "SRCR domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "SRCR", "pathway_ids": ["R-BTA-2243919", "R-HSA-2243919", "R-DRE-114608", "R-HSA-3000480", "R-DRE-2243919", "R-RNO-2243919", "R-BTA-2168880", "R-HSA-9662834", "R-HSA-2168880", "R-HSA-1566948", "R-MMU-3000480", "R-MMU-2243919", "R-RNO-114608", "R-HSA-6806942", "R-RNO-977606", "R-HSA-5578768", "R-HSA-114608", "R-BTA-114608", "R-MMU-8852405", "R-HSA-3000471", "R-HSA-9678110", "R-HSA-977606", "R-RNO-8852405", "R-MMU-1566948", "R-MMU-2168880", "R-MMU-5683826", "R-RNO-6806942", "R-MMU-5578768", "R-HSA-8852405", "R-DRE-3000480", "R-BTA-1566948", "R-HSA-9733458", "R-MMU-977606", "R-MMU-3000471", "R-RNO-5578768", "R-HSA-9694614", "R-RNO-1566948", "R-RNO-5683826", "R-MMU-6806942", "R-HSA-5683826", "R-MMU-114608"], "pathways": ["R-BTA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-DRE-114608:r:Platelet degranulation", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-DRE-2243919:r:Crosslinking of collagen fibrils", "R-RNO-2243919:r:Crosslinking of collagen fibrils", "R-BTA-2168880:r:Scavenging of heme from plasma", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-1566948:r:Elastic fibre formation", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-RNO-114608:r:Platelet degranulation", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-5578768:r:Physiological factors", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-MMU-8852405:r:Signaling by MST1", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8852405:r:Signaling by MST1", "R-MMU-1566948:r:Elastic fibre formation", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-5683826:r:Surfactant metabolism", "R-RNO-6806942:r:MET Receptor Activation", "R-MMU-5578768:r:Physiological factors", "R-HSA-8852405:r:Signaling by MST1", "R-DRE-3000480:r:Scavenging by Class A Receptors", "R-BTA-1566948:r:Elastic fibre formation", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-MMU-977606:r:Regulation of Complement cascade", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-5578768:r:Physiological factors", "R-HSA-9694614:r:Attachment and Entry", "R-RNO-1566948:r:Elastic fibre formation", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-5683826:r:Surfactant metabolism", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR001191": {"description": "Geminivirus AL1, replication-associated protein", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Gemini_AL1_REP", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Family"}, "IPR001192": {"description": "Phosphoinositide phospholipase C family", "go_ids": ["GO:0035556"], "go_terms": ["GO:0035556:intracellular signal transduction:P"], "name": "PI-PLC_fam", "pathway_ids": ["PWY-6367", "PWY-7039", "PWY-6351", "PWY-8052", "R-DDI-114604", "R-BTA-112043", "R-MMU-114604", "R-HSA-2871796", "R-MMU-4086398", "R-HSA-167021", "R-HSA-1489509", "R-RNO-202433", "R-MMU-210990", "R-DDI-416476", "R-CEL-5654219", "R-RNO-2871809", "R-MMU-5654221", "R-DDI-1855204", "R-MMU-201556", "R-RNO-210990", "R-HSA-8853659", "R-DME-1855204", "R-DDI-983695", "R-RNO-416476", "R-DDI-399997", "R-MMU-186763", "R-HSA-114604", "R-RNO-212718", "R-HSA-9026527", "R-CEL-1855204", "R-HSA-434316", "R-MMU-112043", "R-HSA-983695", "R-HSA-2424491", "R-RNO-112043", "R-BTA-500657", "R-HSA-5637810", "R-CEL-112043", "R-MMU-5654219", "R-DME-112043", "R-RNO-5654228", "R-HSA-1855204", "R-MMU-399997", "R-DDI-202433", "R-HSA-9664323", "R-HSA-9680350", "R-RNO-2871796", "R-MMU-5654227", "R-HSA-5655253", "R-HSA-202433", "R-SCE-114604", "R-RNO-1169408", "R-HSA-2029485", "R-HSA-9665348", "R-CEL-5654227", "R-CEL-5607764", "R-RNO-399997", "R-MMU-9034793", "R-HSA-500657", "R-BTA-4086398", "R-CEL-5654221", "R-DME-416476", "R-HSA-4086398", "R-MMU-5621480", "R-RNO-434316", "R-HSA-5655291", "R-HSA-418217", "R-HSA-5655332", "R-HSA-2871809", "R-DDI-112043", "R-BTA-399997", "R-HSA-9717207", "R-HSA-5654219", "R-MMU-212718", "R-HSA-201556", "R-RNO-983695", "R-HSA-9027277", "R-RNO-5654227", "R-RNO-5654219", "R-RNO-166016", "R-CEL-114604", "R-HSA-9725370", "R-SPO-202433", "R-MMU-416476", "R-MMU-5607764", "R-DRE-1855204", "R-HSA-166016", "R-RNO-5621480", "R-HSA-5654228", "R-SPO-1855204", "R-MMU-2871796", "R-RNO-2029485", "R-SCE-5607764", "R-CEL-5654228", "R-MMU-2029485", "R-RNO-9026527", "R-MMU-434316", "R-HSA-5621480", "R-HSA-9664565", "R-HSA-5655302", "R-HSA-5654221", "R-HSA-212718", "R-RNO-201556", "R-HSA-9665686", "R-SPO-5607764", "R-RNO-8853659", "R-MMU-166016", "R-HSA-9034793", "R-MMU-8853659", "R-BTA-416476", "R-HSA-5218921", "R-BTA-1855204", "R-CEL-212718", "R-MMU-418217", "R-HSA-418890", "R-CEL-186763", "R-SCE-1855204", "R-SCE-202433", "R-HSA-416476", "R-HSA-1251932", "R-HSA-1169408", "R-HSA-399997", "R-CEL-416476", "R-GGA-1855204", "R-HSA-210990", "R-HSA-112043", "R-HSA-1236382", "R-SPO-114604", "R-MMU-5654228", "R-MMU-1855204", "R-HSA-5607764", "R-MMU-5218921", "R-DDI-1169408", "R-MMU-202433", "R-CEL-202433", "R-RNO-9034793", "R-MMU-500657", "R-BTA-434316", "R-SSC-1855204", "R-HSA-9679191", "R-MMU-983695", "R-MMU-1169408", "R-RNO-5654221", "R-HSA-186763", "R-HSA-5654227", "R-RNO-114604", "R-RNO-5218921", "R-CEL-1169408", "R-RNO-2424491", "R-RNO-5607764", "R-MMU-2871809", "R-DDI-434316", "R-DDI-5607764", "R-RNO-1855204", "R-MMU-2424491", "R-BTA-418217", "R-RNO-186763", "R-MMU-9026527"], "pathways": ["PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-BTA-112043:r:PLC beta mediated events", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-167021:r:PLC-gamma1 signalling", "R-HSA-1489509:r:DAG and IP3 signaling", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-210990:r:PECAM1 interactions", "R-DDI-416476:r:G alpha (q) signalling events", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-201556:r:Signaling by ALK", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-8853659:r:RET signaling", "R-DME-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DDI-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-416476:r:G alpha (q) signalling events", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-MMU-112043:r:PLC beta mediated events", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2424491:r:DAP12 signaling", "R-RNO-112043:r:PLC beta mediated events", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-CEL-112043:r:PLC beta mediated events", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DME-112043:r:PLC beta mediated events", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-DDI-202433:r:Generation of second messenger molecules", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-202433:r:Generation of second messenger molecules", "R-SCE-114604:r:GPVI-mediated activation cascade", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-4086398:r:Ca2+ pathway", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-5621480:r:Dectin-2 family", "R-RNO-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-112043:r:PLC beta mediated events", "R-BTA-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-201556:r:Signaling by ALK", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-SPO-202433:r:Generation of second messenger molecules", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-5621480:r:Dectin-2 family", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-201556:r:Signaling by ALK", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-8853659:r:RET signaling", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-CEL-186763:r:Downstream signal transduction", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-202433:r:Generation of second messenger molecules", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-CEL-416476:r:G alpha (q) signalling events", "R-GGA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-210990:r:PECAM1 interactions", "R-HSA-112043:r:PLC beta mediated events", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-SPO-114604:r:GPVI-mediated activation cascade", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-MMU-202433:r:Generation of second messenger molecules", "R-CEL-202433:r:Generation of second messenger molecules", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-BTA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-SSC-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-2424491:r:DAP12 signaling", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1"], "type": "Family"}, "IPR001193": {"description": "Membrane-bound transcription factor site-2 protease", "go_ids": ["GO:0004222", "GO:0006508", "GO:0016020"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0016020:membrane:C"], "name": "MBTPS2", "pathway_ids": ["R-HSA-1655829", "R-BTA-381033", "R-MMU-8874177", "R-HSA-8963889", "R-HSA-8874177", "R-BTA-8874211", "R-MMU-8874211", "R-MMU-381033", "R-HSA-8874211", "R-MMU-1655829", "R-BTA-1655829", "R-BTA-8874177", "R-HSA-381033"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-BTA-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-MMU-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-BTA-8874211:r:CREB3 factors activate genes", "R-MMU-8874211:r:CREB3 factors activate genes", "R-MMU-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-HSA-8874211:r:CREB3 factors activate genes", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-BTA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-BTA-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-HSA-381033:r:ATF6 (ATF6-alpha) activates chaperones"], "type": "Family"}, "IPR001194": {"description": "cDENN domain", "go_ids": [], "go_terms": [], "name": "cDENN_dom", "pathway_ids": ["R-HSA-1483248", "R-HSA-5357905", "R-MMU-8876198", "R-CEL-8876198", "R-HSA-1660499", "R-DME-8876198", "R-MMU-5357905", "R-RNO-8876198", "R-RNO-5357905", "R-HSA-8876198", "R-SPO-8876198", "R-MMU-1483248", "R-CEL-1483248"], "pathways": ["R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane"], "type": "Domain"}, "IPR001195": {"description": "Glycophorin", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Glycophorin", "pathway_ids": ["R-HSA-202733"], "pathways": ["R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR001197": {"description": "Large ribosomal subunit protein uL16, eukaryota/archaea", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uL16_euk_arch", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-SCE-9954709", "R-SPO-975957", "R-DRE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954716", "R-CEL-9954714", "R-SSC-72706", "R-SPO-9954709", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-SPO-975956", "R-BTA-156827", "R-RNO-975957", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-DRE-9954714", "R-SCE-975956", "R-CEL-1799339", "R-SSC-9954714", "R-HSA-72706", "R-CEL-156827", "R-SSC-1799339", "R-RNO-6791226", "R-DRE-1799339", "R-SSC-975957", "R-HSA-6791226", "R-DDI-156827", "R-RNO-975956", "R-SSC-72689", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-72689", "R-SCE-72706", "R-RNO-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-975956", "R-DRE-975956", "R-BTA-9954716", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-SSC-6791226", "R-BTA-9954709", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-SSC-9954716", "R-DDI-9954716", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001199": {"description": "Cytochrome b5-like heme/steroid binding domain", "go_ids": [], "go_terms": [], "name": "Cyt_B5-like_heme/steroid-bd", "pathway_ids": ["R-HSA-6798695", "R-HSA-1989781", "R-HSA-9013405", "R-RNO-1237044", "R-DRE-2046105", "R-MMU-9013408", "R-RNO-2046106", "R-HSA-5693565", "R-MMU-9013404", "R-HSA-2046105", "R-SCE-196836", "R-HSA-203615", "R-BTA-9609523", "R-MMU-69473", "R-HSA-5693607", "R-BTA-196836", "R-MMU-9707616", "R-HSA-196836", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-9013408", "R-HSA-9609523", "R-DME-196836", "R-SSC-196836", "R-HSA-69473", "R-GGA-9609523", "R-SSC-9609523", "R-BTA-2046106", "R-DME-1614517", "R-GGA-6798695", "R-RNO-203615", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-211945", "R-HSA-8980692", "R-RNO-1614517", "R-MMU-6798695", "R-MMU-3108214", "R-HSA-2046106", "R-MMU-5693571", "R-RNO-6798695", "R-MMU-211945", "R-SCE-75105", "R-DME-983168", "R-SPO-6798695", "R-RNO-2046105", "R-SSC-6798695", "R-HSA-3108214", "R-HSA-211945", "R-DRE-2046106", "R-HSA-1614517", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-196836", "R-MMU-203615", "R-RNO-9609523", "R-HSA-1237044", "R-MMU-5693565", "R-HSA-9013423", "R-XTR-1237044", "R-DME-9609523", "R-MMU-9609523", "R-RNO-9707616", "R-MMU-1614517", "R-MMU-5693607", "R-MMU-1237044", "R-MMU-196836", "R-MMU-2046106", "R-SPO-75105", "R-HSA-9707616", "R-HSA-983168", "R-HSA-1660661", "R-RNO-9013423", "R-HSA-5693571", "R-SPO-9707616", "R-GGA-196836", "R-SPO-9609523", "R-MMU-983168", "R-RNO-1660661", "R-SCE-9609523", "R-SPO-196836", "R-BTA-1237044", "R-MMU-2046105", "R-BTA-2046105", "R-MMU-1660661"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DRE-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-SCE-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-203615:r:eNOS activation", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-9707616:r:Heme signaling", "R-HSA-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-196836:r:Vitamin C (ascorbate) metabolism", "R-SSC-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-GGA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-1614517:r:Sulfide oxidation to sulfate", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-203615:r:eNOS activation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-1614517:r:Sulfide oxidation to sulfate", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-DRE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-1614517:r:Sulfide oxidation to sulfate", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-203615:r:eNOS activation", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-XTR-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9707616:r:Heme signaling", "R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9707616:r:Heme signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SPO-9707616:r:Heme signaling", "R-GGA-196836:r:Vitamin C (ascorbate) metabolism", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-196836:r:Vitamin C (ascorbate) metabolism", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-BTA-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Domain"}, "IPR001202": {"description": "WW domain", 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"R-MMU-4641257", "R-HSA-381676", "R-HSA-1253288", "R-MMU-9013406", "R-DME-446388", "R-HSA-8948751", "R-MMU-6798695", "R-MMU-2032785", "R-MMU-8854518", "R-HSA-9860927", "R-MMU-2173788", "R-RNO-983168", "R-DME-8951671", "R-HSA-8940973", "R-DME-8941858", "R-DME-2122948", "R-CFA-1251985", "R-HSA-9819196", "R-MMU-5610780", "R-CFA-8939236", "R-HSA-9725554", "R-SPO-6811555", "R-HSA-5626467", "R-HSA-2122948", "R-HSA-9619665", "R-DME-8866904", "R-HSA-936440", "R-MMU-9013148", "R-HSA-1169408", "R-DME-9860927", "R-HSA-1660499", "R-CEL-9013149", "R-CEL-1251985", "R-HSA-2565942", "R-HSA-5578768", "R-SCE-9013406", "R-HSA-3214841", "R-HSA-6802946", "R-HSA-9035034", "R-DME-9013406", "R-SPO-983168", "R-DRE-8951671", "R-CFA-8951671", "R-MMU-168638", "R-SCE-983168", "R-HSA-5620912", "R-MMU-4608870", "R-HSA-9918481", "R-HSA-2173796", "R-RNO-8948747", "R-DRE-5689880", "R-HSA-8866907", "R-HSA-9013420", "R-HSA-9013508", "R-RNO-390522", "R-HSA-8948747", "R-MMU-2028269", "R-HSA-2173791", "R-CEL-9913351", "R-DME-6811555", "R-HSA-983168", "R-MMU-1169408", "R-HSA-5632684", "R-DME-9013418", "R-RNO-9913351", "R-HSA-428543", "R-CEL-2028269", "R-DME-5632684", "R-MMU-9013026", "R-HSA-9692916", "R-HSA-390522", "R-MMU-983168", "R-MMU-6811555", "R-MMU-8866904", "R-MMU-936440", "R-HSA-9013406", "R-SCE-5668599", "R-DRE-1251985", "R-CFA-2173796", "R-HSA-380259", "R-HSA-2028269", "R-MMU-2173795", "R-HSA-9013409", "R-HSA-9013405", "R-RNO-8948751", "R-HSA-168638", "R-MMU-8941858", "R-HSA-6802952", "R-MMU-9770562", "R-RNO-2028269", "R-HSA-5689880", "R-DME-8866907", "R-RNO-5693565", "R-DME-2173788", "R-MMU-9013408", "R-MMU-6804756", "R-RNO-72163", "R-HSA-5693565", "R-MMU-8948751", "R-DRE-8939236", "R-DME-8948751", "R-DRE-8941858", "R-MMU-380320", "R-MMU-5689880", "R-DME-390150", "R-MMU-9013420", "R-BTA-6804756", "R-CEL-9770562", "R-SPO-5668599", "R-DME-390193", "R-DRE-8866907", "R-HSA-9013507", "R-MMU-5620912", "R-DME-1251985", "R-DRE-201451", "R-HSA-6802955", "R-BTA-72163", "R-MMU-8866654", "R-MMU-9035034", "R-DME-4641257", "R-MMU-3214841", "R-HSA-6802948", "R-MMU-380259", "R-MMU-72163", "R-HSA-8951671", "R-MMU-2173796", "R-DME-114608", "R-HSA-3000171", "R-MMU-8948747", "R-MMU-380270", "R-RNO-9013148", "R-DME-1253288", "R-HSA-162588", "R-DME-6804756", "R-MMU-9013423", "R-HSA-8866654", "R-HSA-72163", "R-MMU-4641258", "R-DME-390098", "R-HSA-6804756", "R-DME-390089", "R-HSA-9013026", "R-HSA-8986944", "R-CEL-8948751", "R-CFA-2028269", "R-DRE-4608870", "R-GGA-8866904", "R-DME-201451", "R-MMU-9860927", "R-HSA-9656223", "R-DME-983168", "R-MMU-5674135", "R-CEL-2032785", "R-MMU-8980692", "R-HSA-1251985", "R-MMU-8951671", "R-RNO-1169408", "R-HSA-2672351", "R-CEL-8951671", "R-HSA-201451", "R-CFA-9860927", "R-HSA-9013106", "R-DRE-4641257", "R-MMU-380284", "R-CEL-983168", "R-DME-2028269"], "pathways": ["R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-201451:r:Signaling by BMP", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DRE-2028269:r:Signaling by Hippo", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-BTA-6811555:r:PI5P Regulates TP53 Acetylation", "R-SCE-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CEL-9013420:r:RHOU GTPase cycle", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DDI-2028269:r:Signaling by Hippo", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-CEL-8980692:r:RHOA GTPase cycle", "R-CFA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-GGA-1251985:r:Nuclear signaling by ERBB4", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-9035034:r:RHOF GTPase cycle", "R-RNO-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-9035034:r:RHOF GTPase cycle", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-4641257:r:Degradation of AXIN", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DME-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-DME-8948747:r:Regulation of PTEN localization", "R-SCE-9013420:r:RHOU GTPase cycle", "R-HSA-9796292:r:Formation of axial mesoderm", "R-DRE-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-HSA-373753:r:Nephrin family interactions", "R-CEL-4641258:r:Degradation of DVL", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-4641258:r:Degradation of DVL", "R-DRE-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-373753:r:Nephrin family interactions", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-GGA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-8980692:r:RHOA GTPase cycle", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-4641257:r:Degradation of AXIN", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-CFA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-CFA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-SPO-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5578768:r:Physiological factors", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-CFA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-8948747:r:Regulation of PTEN localization", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-8948747:r:Regulation of PTEN localization", "R-MMU-2028269:r:Signaling by Hippo", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-CEL-2028269:r:Signaling by Hippo", "R-DME-5632684:r:Hedgehog 'on' state", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-390522:r:Striated Muscle Contraction", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-CFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2028269:r:Signaling by Hippo", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-2028269:r:Signaling by Hippo", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-RNO-5693565:r:Recruitment and 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Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SSC-113418:r:Formation of the Early Elongation Complex", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Domain"}, "IPR001223": {"description": "Glycoside hydrolase family 18, catalytic domain", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro18_cat", "pathway_ids": ["R-MMU-2534343", "R-HSA-6798695", "R-HSA-189085", "R-DRE-114608", "R-PFA-189085", "R-DME-6798695", "R-CEL-6798695", "R-SCE-6798695", "R-DDI-114608", "R-RNO-114608", "R-CEL-189085", "R-HSA-114608", "R-BTA-114608", "R-HSA-2534343", "R-SCE-189085", "R-PFA-6798695", "R-MMU-6798695", "R-RNO-189085", "R-MMU-189085", "R-XTR-114608", "R-DME-189085", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-DRE-114608:r:Platelet degranulation", "R-PFA-189085:r:Digestion of dietary carbohydrate", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-CEL-189085:r:Digestion of dietary carbohydrate", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-SCE-189085:r:Digestion of dietary carbohydrate", "R-PFA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-XTR-114608:r:Platelet degranulation", "R-DME-189085:r:Digestion of dietary carbohydrate", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR001227": {"description": "Acyl transferase domain superfamily", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "Ac_transferase_dom_sf", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-DDI-75105", "R-DME-77289", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-RNO-199220", "R-SCE-77289", "R-HSA-75105", "R-MMU-77289", "R-DDI-199220", "R-SPO-77289", "R-HSA-9918481", "R-HSA-2426168", "R-HSA-77289"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SCE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation"], "type": "Homologous_superfamily"}, "IPR001228": {"description": "2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase", "go_ids": ["GO:0008299", "GO:0050518"], "go_terms": ["GO:0008299:isoprenoid biosynthetic process:P", "GO:0050518:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity:F"], "name": "IspD", "pathway_ids": ["PWY-7560"], "pathways": ["PWY-7560:t:methylerythritol phosphate pathway II"], "type": "Family"}, "IPR001229": {"description": "Jacalin-like lectin domain", "go_ids": [], "go_terms": [], "name": "Jacalin-like_lectin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001232": {"description": "S-phase kinase-associated protein 1-like", "go_ids": ["GO:0006511"], 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recovery of Tat-mediated HIV elongation", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-1170546:r:Prolactin receptor signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-RNO-917937:r:Iron uptake and transport", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-DDI-68949:r:Orc1 removal from chromatin", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-69231:r:Cyclin D associated events in G1", "R-BTA-8951664:r:Neddylation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-1170546:r:Prolactin receptor signaling", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-68949:r:Orc1 removal from chromatin", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Family"}, "IPR001233": {"description": "RNA-splicing ligase, RtcB", "go_ids": ["GO:0008452", "GO:0006396"], "go_terms": ["GO:0008452:RNA ligase activity:F", "GO:0006396:RNA processing:P"], "name": "RtcB", "pathway_ids": ["PWY-7803", "R-HSA-6784531"], "pathways": ["PWY-7803:t:tRNA splicing II", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR001236": {"description": "Lactate/malate dehydrogenase, N-terminal", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": 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"R-HSA-195399", "R-MMU-5654719", "R-SSC-399956", "R-MMU-202433", "R-MMU-5357786", "R-SSC-9027276", "R-MMU-8849469", "R-CEL-392517", "R-DRE-9020958", "R-RNO-8935690", "R-MMU-3928663", "R-DRE-190322", "R-MMU-9006335", "R-RNO-195399", "R-CEL-180336", "R-MMU-418592", "R-HSA-5213460", "R-DRE-8853659", "R-RNO-5218921", "R-HSA-9705462", "R-MMU-177504", "R-DME-209228", "R-SSC-8851805", "R-HSA-2892247", "R-RNO-186763", "R-MMU-8857538", "R-MMU-3295583", "R-DRE-3928663", "R-HSA-9696273", "R-CEL-5654704", "R-RNO-190322", "R-MMU-8849468", "R-RNO-8934903", "R-BTA-5689880", "R-MMU-3928665", "R-HSA-2871796", "R-HSA-9669936", "R-RNO-9020591", "R-CEL-8941858", "R-HSA-198745", "R-RNO-9018519", "R-MMU-5685938", "R-SSC-8935690", "R-HSA-5654695", "R-CEL-446343", "R-CEL-9013407", "R-BTA-6811558", "R-MMU-202733", "R-DRE-5654228", "R-BTA-210990", "R-SSC-912631", "R-RNO-375165", "R-HSA-8875513", "R-DME-214842", "R-HSA-6802955", "R-HSA-9702577", "R-DME-5654727", "R-HSA-8984722", "R-HSA-6802948", "R-RNO-190374", "R-RNO-5675221", "R-HSA-5654700", "R-DRE-1227986", "R-CEL-1433557", "R-CEL-2682334", "R-MMU-179812", "R-RNO-5654228", "R-MMU-1250196", "R-DME-5674499", "R-MMU-194306", "R-HSA-9634597", "R-HSA-201681", "R-MMU-5674135", "R-HSA-1059683", "R-GGA-399954", "R-HSA-202433", "R-HSA-201451", "R-DRE-877312", "R-HSA-6788467", "R-DDI-5674499", "R-SSC-373753", "R-HSA-3656532", "R-RNO-9860927", "R-MMU-9034793", "R-RNO-8874081", "R-BTA-2871837", "R-HSA-9669924", "R-HSA-388844", "R-MMU-9020591", "R-RNO-354192", "R-HSA-8849474", "R-CEL-5654221", "R-MMU-2672351", "R-MMU-190377", "R-HSA-9013148", "R-HSA-1963642", "R-RNO-5674135", "R-DME-8863795", "R-HSA-2033519", "R-MMU-5621480", "R-SSC-2980767", "R-DDI-5689880", "R-DME-5654219", "R-GGA-912631", "R-RNO-399956", "R-MMU-2173789", "R-HSA-9603505", "R-HSA-9696270", "R-MMU-190322", "R-MMU-5675482", "R-HSA-167590", "R-SSC-4420097", "R-HSA-190322", "R-HSA-74749", "R-BTA-418885", "R-HSA-180336", "R-MMU-1251985", "R-HSA-9034013", "R-HSA-9009391", "R-DME-5654712", "R-DRE-1257604", "R-SSC-3928663", "R-HSA-5357956", "R-HSA-187706", "R-CEL-179812", "R-HSA-3928665", "R-MMU-8851907", "R-MMU-5654687", "R-MMU-9032759", "R-RNO-5654733", "R-HSA-9027277", "R-HSA-2428928", "R-HSA-428890", "R-MMU-9696273", "R-HSA-9725370", "R-DME-210688", "R-GGA-388844", "R-MMU-9856649", "R-HSA-186797", "R-HSA-6798695", "R-MMU-416476", "R-HSA-8849469", "R-HSA-8875555", "R-SSC-5675221", "R-DRE-5654689", "R-MMU-1306955", "R-HSA-112411", "R-MMU-2173791", "R-HSA-9669929", "R-GGA-2029482", "R-MMU-4420097", "R-RNO-191650", "R-RNO-190370", "R-HSA-5654693", "R-RNO-198203", "R-MMU-3000171", "R-DRE-69231", "R-HSA-446343", "R-CFA-5673001", "R-HSA-399955", "R-DRE-5654726", "R-DRE-877300", "R-BTA-5578768", "R-HSA-5654221", "R-HSA-9652282", "R-CEL-216083", "R-DDI-1483248", "R-HSA-9717264", "R-CEL-9841922", "R-HSA-5675482", "R-HSA-9024909", "R-CEL-5663213", "R-SSC-9032759", "R-HSA-9013695", "R-DDI-450302", "R-RNO-450302", "R-DME-209447", "R-MMU-202427", "R-MMU-8875513", "R-GGA-3928663", "R-HSA-3371378", "R-DRE-5654700", "R-HSA-9013407", "R-DRE-456926", "R-MMU-8863795", "R-PFA-5689880", "R-DME-937042", "R-MMU-2179392", "R-HSA-5654687", "R-SSC-877312", "R-MMU-8852405", "R-CEL-3928663", "R-RNO-110056", "R-DME-428890", "R-HSA-9938206", "R-MMU-168638", "R-RNO-201451", "R-CEL-5654710", "R-HSA-9025046", "R-DRE-1059683", "R-MMU-5674499", "R-DME-4086398", "R-HSA-9674403", "R-MMU-9603381", "R-CEL-418592", "R-HSA-216083", "R-DDI-3295583", "R-RNO-9034793", "R-CEL-445144", "R-DME-5675482", "R-HSA-9665233", "R-CEL-416572", "R-MMU-1169408", "R-HSA-975155", "R-HSA-186763", "R-HSA-177504", "R-HSA-9706377", "R-HSA-383280", "R-MMU-6783783", "R-SSC-389357", "R-BTA-9020702", "R-MMU-3928662", "R-HSA-5654710", "R-HSA-9014325", "R-RNO-9766229", "R-RNO-202430", "R-DME-179812", "R-DME-9013423", "R-DDI-450321", "R-RNO-2871837", "R-MMU-177929", "R-RNO-1306955", "R-HSA-9607240", "R-CEL-3928664", "R-MMU-8941858", "R-HSA-9026357", "R-DME-2173788", "R-HSA-9006335", "R-RNO-202433", "R-MMU-937072", "R-MMU-9009391", "R-HSA-5693565", "R-MMU-5689896", "R-HSA-9669935", "R-DME-5689896", "R-HSA-6806942", "R-DRE-5621575", "R-HSA-202427", "R-RNO-8847993", "R-CEL-1257604", "R-RNO-210990", "R-MMU-5654706", "R-HSA-389359", "R-SSC-112411", "R-RNO-1963642", "R-HSA-9693928", "R-HSA-2682334", "R-DRE-5621480", "R-DME-1251985", "R-HSA-9692913", "R-HSA-114604", "R-MMU-5578768", "R-DME-9013149", "R-HSA-5654689", "R-RNO-9732724", "R-HSA-418592", "R-RNO-2029481", "R-RNO-9013407", "R-HSA-983231", "R-DME-5627123"], "pathways": ["R-SSC-3928662:r:EPHB-mediated forward signaling", "R-HSA-9702590:r:gilteritinib-resistant FLT3 mutants", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-69416:r:Dimerization of procaspase-8", "R-HSA-1433559:r:Regulation of KIT signaling", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-186797:r:Signaling by PDGF", "R-BTA-2424491:r:DAP12 signaling", "R-SSC-1227986:r:Signaling by ERBB2", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-SSC-8851907:r:MET activates PI3K/AKT signaling", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9702636:r:tandutinib-resistant FLT3 mutants", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-HSA-9717319:r:brigatinib-resistant ALK mutants", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-GGA-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9717326:r:crizotinib-resistant ALK mutants", "R-HSA-74752:r:Signaling by Insulin receptor", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-8865999:r:MET activates PTPN11", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-6783783:r:Interleukin-10 signaling", "R-CEL-190322:r:FGFR4 ligand binding and activation", "R-MMU-75893:r:TNF signaling", "R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-DME-1236394:r:Signaling by ERBB4", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-MMU-8853659:r:RET signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-77387:r:Insulin receptor recycling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-110478:r:Insulin signaling pathway", "R-DRE-177929:r:Signaling by EGFR", "R-HSA-9620244:r:Long-term potentiation", "R-GGA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9702998:r:linifanib-resistant FLT3 mutants", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DRE-190370:r:FGFR1b ligand binding and activation", "R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-389356:r:Co-stimulation by CD28", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-209214:r:Phosphorylation of SMO", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-171007:r:p38MAPK events", "R-RNO-8932505:r:DAG1 core M3 glycosylations", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9013420:r:RHOU GTPase cycle", "R-GGA-210990:r:PECAM1 interactions", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-180292:r:GAB1 signalosome", "R-CEL-418594:r:G alpha (i) signalling events", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-SSC-8875791:r:MET activates STAT3", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-373753:r:Nephrin family interactions", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-GGA-9732724:r:IFNG signaling activates MAPKs", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-HSA-912631:r:Regulation of signaling by CBL", "R-DME-9020558:r:Interleukin-2 signaling", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-GGA-354192:r:Integrin signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-8866376:r:Reelin signalling pathway", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-186763:r:Downstream signal transduction", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-74713:r:IRS activation", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-210991:r:Basigin interactions", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-170984:r:ARMS-mediated activation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-GGA-5673000:r:RAF activation", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9702620:r:quizartinib-resistant FLT3 mutants", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-191650:r:Regulation of gap junction activity", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-MMU-191650:r:Regulation of gap junction activity", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9717329:r:lorlatinib-resistant ALK mutants", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-HSA-877312:r:Regulation of IFNG signaling", "R-DME-69416:r:Dimerization of procaspase-8", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DRE-9851151:r:MDK and PTN in ALK signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-DME-177929:r:Signaling by EGFR", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-RNO-74713:r:IRS activation", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-BTA-202670:r:ERKs are inactivated", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2029481:r:FCGR activation", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9717301:r:NVP-TAE684-resistant ALK mutants", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-170968:r:Frs2-mediated activation", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DME-201681:r:TCF dependent signaling in response to WNT", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-8865999:r:MET activates PTPN11", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DME-5673000:r:RAF activation", "R-CEL-525793:r:Myogenesis", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-RNO-5578768:r:Physiological factors", "R-CEL-180292:r:GAB1 signalosome", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-CEL-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-373753:r:Nephrin family interactions", "R-CEL-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-354192:r:Integrin signaling", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-DRE-9842663:r:Signaling by LTK", "R-DRE-912631:r:Regulation of signaling by CBL", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5578768:r:Physiological factors", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-449836:r:Other interleukin signaling", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DME-170968:r:Frs2-mediated activation", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-RNO-186797:r:Signaling by PDGF", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-PFA-5675482:r:Regulation of necroptotic cell death", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-MMU-6806942:r:MET Receptor Activation", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-8866376:r:Reelin signalling pathway", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-BTA-5621480:r:Dectin-2 family", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-9702600:r:midostaurin-resistant FLT3 mutants", "R-SSC-8875656:r:MET receptor recycling", "R-PFA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-210993:r:Tie2 Signaling", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9702632:r:sunitinib-resistant FLT3 mutants", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-DME-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-3371378:r:Regulation by c-FLIP", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-DME-209209:r:Formation of the activated receptor complex", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-449836:r:Other interleukin signaling", "R-RNO-5673000:r:RAF activation", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-182971:r:EGFR downregulation", "R-HSA-2424491:r:DAP12 signaling", "R-PFA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-HSA-8983432:r:Interleukin-15 signaling", "R-PFA-5673000:r:RAF activation", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-GGA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-DME-201451:r:Signaling by BMP", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-BTA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9717316:r:alectinib-resistant ALK mutants", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-392517:r:Rap1 signalling", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-SSC-2029481:r:FCGR activation", "R-MMU-3928664:r:Ephrin signaling", "R-MMU-437239:r:Recycling pathway of L1", "R-DDI-1632852:r:Macroautophagy", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-BTA-3928664:r:Ephrin signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-DRE-8874081:r:MET activates PTK2 signaling", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-8875656:r:MET receptor recycling", "R-CEL-186797:r:Signaling by PDGF", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-187042:r:TRKA activation by NGF", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-RNO-8866376:r:Reelin signalling pathway", "R-MMU-9020933:r:Interleukin-23 signaling", "R-MMU-8935690:r:Digestion", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-DDI-9020702:r:Interleukin-1 signaling", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-DME-1227986:r:Signaling by ERBB2", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-BTA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-RNO-8853659:r:RET signaling", "R-CEL-177929:r:Signaling by EGFR", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DRE-190373:r:FGFR1c ligand binding and activation", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-CEL-432142:r:Platelet sensitization by LDL", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DRE-210990:r:PECAM1 interactions", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-3642279:r:TGFBR2 MSI Frameshift Mutants in Cancer", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-GGA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-418885:r:DCC mediated attractive signaling", "R-RNO-2672351:r:Stimuli-sensing channels", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DDI-2871796:r:FCERI mediated MAPK activation", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-354192:r:Integrin signaling", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-SSC-6807004:r:Negative regulation of MET activity", "R-SSC-9020956:r:Interleukin-27 signaling", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-DME-77387:r:Insulin receptor recycling", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-432142:r:Platelet sensitization by LDL", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-RNO-389356:r:Co-stimulation by CD28", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1236394:r:Signaling by ERBB4", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9830674:r:Formation of the ureteric bud", "R-BTA-1433559:r:Regulation of KIT signaling", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DRE-1295596:r:Spry regulation of FGF signaling", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-BTA-1227986:r:Signaling by ERBB2", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-74752:r:Signaling by Insulin receptor", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-CEL-182971:r:EGFR downregulation", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-9702509:r:FLT3 mutants bind TKIs", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-186763:r:Downstream signal transduction", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-389356:r:Co-stimulation by CD28", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9702581:r:crenolanib-resistant FLT3 mutants", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-1227986:r:Signaling by ERBB2", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-109704:r:PI3K Cascade", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9824272:r:Somitogenesis", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-201556:r:Signaling by ALK", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-MMU-1502540:r:Signaling by Activin", "R-MMU-74713:r:IRS activation", "R-HSA-8852405:r:Signaling by MST1", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-5218900:r:CASP8 activity is inhibited", "R-DME-6798695:r:Neutrophil degranulation", "R-GGA-392517:r:Rap1 signalling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-CEL-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-BTA-210993:r:Tie2 Signaling", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-RNO-9020702:r:Interleukin-1 signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8875791:r:MET activates STAT3", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-8866376:r:Reelin signalling pathway", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-187042:r:TRKA activation by NGF", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-HSA-1266695:r:Interleukin-7 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-DME-5674135:r:MAP2K and MAPK activation", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-3928664:r:Ephrin signaling", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-DDI-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9702605:r:pexidartinib-resistant FLT3 mutants", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-525793:r:Myogenesis", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9702614:r:ponatinib-resistant FLT3 mutants", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-8849473:r:PTK6 Expression", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-GGA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SSC-2424491:r:DAP12 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-1236394:r:Signaling by ERBB4", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-5673000:r:RAF activation", "R-HSA-9020702:r:Interleukin-1 signaling", "R-CEL-8849470:r:PTK6 Regulates Cell Cycle", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-1266695:r:Interleukin-7 signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-167021:r:PLC-gamma1 signalling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-5673000:r:RAF activation", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-8942233:r:Intestinal infectious diseases", "R-SSC-982772:r:Growth hormone receptor signaling", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-HSA-9609690:r:HCMV Early Events", "R-GGA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-9020958:r:Interleukin-21 signaling", "R-RNO-8875656:r:MET receptor recycling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8851805:r:MET activates RAS signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-6806942:r:MET Receptor Activation", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-DME-1502540:r:Signaling by Activin", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-1181150:r:Signaling by NODAL", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-8874081:r:MET activates PTK2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-912631:r:Regulation of signaling by CBL", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-CEL-77387:r:Insulin receptor recycling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-MMU-182971:r:EGFR downregulation", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-373753:r:Nephrin family interactions", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-432142:r:Platelet sensitization by LDL", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-75893:r:TNF signaling", "R-DRE-191650:r:Regulation of gap junction activity", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DME-9749641:r:Aspirin ADME", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-DME-1266695:r:Interleukin-7 signaling", "R-HSA-164944:r:Nef and signal transduction", "R-HSA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-SSC-877300:r:Interferon gamma signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DRE-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-5621480:r:Dectin-2 family", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5689603:r:UCH proteinases", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9669933:r:Signaling by kinase domain mutants of KIT", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-3928664:r:Ephrin signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-SSC-1433559:r:Regulation of KIT signaling", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-4086400:r:PCP/CE pathway", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-877300:r:Interferon gamma signaling", "R-GGA-1433559:r:Regulation of KIT signaling", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-9702624:r:sorafenib-resistant FLT3 mutants", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-SSC-210990:r:PECAM1 interactions", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-1236394:r:Signaling by ERBB4", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-170984:r:ARMS-mediated activation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-392517:r:Rap1 signalling", "R-MMU-5673000:r:RAF activation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-5673000:r:RAF activation", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-69416:r:Dimerization of procaspase-8", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-8935690:r:Digestion", "R-DRE-201556:r:Signaling by ALK", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-201451:r:Signaling by BMP", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-RNO-177929:r:Signaling by EGFR", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-HSA-9706369:r:Negative regulation of FLT3", "R-PFA-430116:r:GP1b-IX-V activation signalling", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-BTA-180292:r:GAB1 signalosome", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-109704:r:PI3K Cascade", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-DME-9020702:r:Interleukin-1 signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-877300:r:Interferon gamma signaling", "R-HSA-180292:r:GAB1 signalosome", "R-RNO-5621480:r:Dectin-2 family", "R-DRE-1266695:r:Interleukin-7 signaling", "R-MMU-74752:r:Signaling by Insulin receptor", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-170968:r:Frs2-mediated activation", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-9706369:r:Negative regulation of FLT3", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-373753:r:Nephrin family interactions", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-180292:r:GAB1 signalosome", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1502540:r:Signaling by Activin", "R-DRE-354192:r:Integrin signaling", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DME-3371378:r:Regulation by c-FLIP", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-430116:r:GP1b-IX-V activation signalling", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-CEL-8849472:r:PTK6 Down-Regulation", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-109704:r:PI3K Cascade", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-DME-430116:r:GP1b-IX-V activation signalling", "R-MMU-9842663:r:Signaling by LTK", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-525793:r:Myogenesis", "R-DME-180292:r:GAB1 signalosome", "R-MMU-389948:r:Co-inhibition by PD-1", "R-DME-209190:r:Phosphorylation of CI", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-9645135:r:STAT5 Activation", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-GGA-389356:r:Co-stimulation by CD28", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-CEL-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-4086398:r:Ca2+ pathway", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-GGA-2672351:r:Stimuli-sensing channels", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-HSA-8866376:r:Reelin signalling pathway", "R-RNO-449836:r:Other interleukin signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-3295583:r:TRP channels", "R-BTA-446353:r:Cell-extracellular matrix interactions", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-HSA-9702596:r:lestaurtinib-resistant FLT3 mutants", "R-RNO-1433559:r:Regulation of KIT signaling", "R-RNO-373753:r:Nephrin family interactions", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-HSA-5673000:r:RAF activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-5673000:r:RAF activation", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-RNO-6806942:r:MET Receptor Activation", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-SSC-389356:r:Co-stimulation by CD28", "R-RNO-445144:r:Signal transduction by L1", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-DME-8985947:r:Interleukin-9 signaling", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DRE-430116:r:GP1b-IX-V activation signalling", "R-HSA-9703009:r:tamatinib-resistant FLT3 mutants", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-DRE-8983432:r:Interleukin-15 signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-1502540:r:Signaling by Activin", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-182971:r:EGFR downregulation", "R-CEL-170968:r:Frs2-mediated activation", "R-HSA-8985947:r:Interleukin-9 signaling", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-CFA-9851151:r:MDK and PTN in ALK signaling", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-HSA-9674404:r:Sorafenib-resistant PDGFR mutants", "R-HSA-9717323:r:ceritinib-resistant ALK mutants", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-109704:r:PI3K Cascade", "R-DRE-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-SSC-8875555:r:MET activates RAP1 and RAC1", "R-DDI-392517:r:Rap1 signalling", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-PFA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-201556:r:Signaling by ALK", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-HSA-9702569:r:KW2449-resistant FLT3 mutants", "R-MMU-74749:r:Signal attenuation", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-373753:r:Nephrin family interactions", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-CEL-912631:r:Regulation of signaling by CBL", "R-SSC-399954:r:Sema3A PAK dependent Axon repulsion", "R-SSC-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-RNO-392517:r:Rap1 signalling", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-190370:r:FGFR1b ligand binding and activation", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-177929:r:Signaling by EGFR", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-201556:r:Signaling by ALK", "R-BTA-9013407:r:RHOH GTPase cycle", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-PFA-5213460:r:RIPK1-mediated regulated necrosis", "R-BTA-912631:r:Regulation of signaling by CBL", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DRE-5654710:r:PI-3K cascade:FGFR3", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-BTA-9766229:r:Degradation of CDH1", "R-CEL-201681:r:TCF dependent signaling in response to WNT", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CFA-1433559:r:Regulation of KIT signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-SSC-399956:r:CRMPs in Sema3A signaling", "R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-392517:r:Rap1 signalling", "R-DRE-9020958:r:Interleukin-21 signaling", "R-RNO-8935690:r:Digestion", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-DRE-8853659:r:RET signaling", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-SSC-8851805:r:MET activates RAS signaling", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-3295583:r:TRP channels", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9696273:r:RND1 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-190322:r:FGFR4 ligand binding and activation", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-RNO-9020591:r:Interleukin-12 signaling", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-198745:r:Signalling to STAT3", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SSC-8935690:r:Digestion", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-CEL-9013407:r:RHOH GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-BTA-210990:r:PECAM1 interactions", "R-SSC-912631:r:Regulation of signaling by CBL", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9702577:r:semaxanib-resistant FLT3 mutants", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DRE-1227986:r:Signaling by ERBB2", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-9634597:r:GPER1 signaling", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-GGA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-201451:r:Signaling by BMP", "R-DRE-877312:r:Regulation of IFNG signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-SSC-373753:r:Nephrin family interactions", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9020591:r:Interleukin-12 signaling", "R-RNO-354192:r:Integrin signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-MMU-5621480:r:Dectin-2 family", "R-SSC-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-GGA-912631:r:Regulation of signaling by CBL", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-HSA-74749:r:Signal attenuation", "R-BTA-418885:r:DCC mediated attractive signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-SSC-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-191650:r:Regulation of gap junction activity", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-69231:r:Cyclin D associated events in G1", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-877300:r:Interferon gamma signaling", "R-BTA-5578768:r:Physiological factors", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-CEL-216083:r:Integrin cell surface interactions", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-9717264:r:ASP-3026-resistant ALK mutants", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-GGA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-3371378:r:Regulation by c-FLIP", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-PFA-5689880:r:Ub-specific processing proteases", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-SSC-877312:r:Regulation of IFNG signaling", "R-MMU-8852405:r:Signaling by MST1", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-RNO-201451:r:Signaling by BMP", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-DRE-1059683:r:Interleukin-6 signaling", "R-MMU-5674499:r:Negative feedback regulation of MAPK pathway", "R-DME-4086398:r:Ca2+ pathway", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-216083:r:Integrin cell surface interactions", "R-DDI-3295583:r:TRP channels", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-CEL-445144:r:Signal transduction by L1", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-6783783:r:Interleukin-10 signaling", "R-SSC-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-RNO-9766229:r:Degradation of CDH1", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-6806942:r:MET Receptor Activation", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DRE-5621480:r:Dectin-2 family", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-5578768:r:Physiological factors", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-2029481:r:FCGR activation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-5627123:r:RHO GTPases activate PAKs"], "type": "Domain"}, "IPR001247": {"description": "Exoribonuclease, phosphorolytic domain 1", "go_ids": [], "go_terms": [], "name": "ExoRNase_PH_dom1", "pathway_ids": ["R-BTA-450604", "R-MMU-450385", "R-DRE-450385", "R-HSA-9930044", "R-XTR-6791226", "R-XTR-450385", "R-CEL-450385", "R-BTA-450385", "R-DDI-6791226", "R-MMU-429958", "R-RNO-450513", "R-SPO-9930044", "R-XTR-450513", "R-RNO-9930044", "R-SCE-450385", "R-RNO-450604", "R-DRE-9930044", "R-SCE-429958", "R-HSA-380994", "R-HSA-9836573", "R-SCE-6791226", "R-CEL-429958", "R-RNO-450385", "R-CEL-6791226", "R-HSA-429958", "R-SPO-429958", "R-MMU-9930044", "R-MMU-6791226", "R-BTA-429958", "R-DDI-429958", "R-DRE-450513", "R-XTR-429958", "R-BTA-6791226", "R-BTA-450513", "R-DRE-450604", "R-SCE-450513", "R-DRE-429958", "R-XTR-450604", "R-CEL-450513", "R-BTA-9930044", "R-RNO-6791226", "R-HSA-450385", "R-XTR-9930044", "R-RNO-429958", "R-MMU-450513", "R-HSA-6791226", "R-DDI-450385", "R-MMU-450604", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-DDI-450513", "R-SPO-6791226", "R-DDI-9930044"], "pathways": ["R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-9930044:r:Nuclear RNA decay", "R-XTR-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-9930044:r:Nuclear RNA decay", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DRE-9930044:r:Nuclear RNA decay", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DDI-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-XTR-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DRE-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-XTR-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-9930044:r:Nuclear RNA decay", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-XTR-9930044:r:Nuclear RNA decay", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-DDI-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9930044:r:Nuclear RNA decay"], "type": "Domain"}, "IPR001248": {"description": "Purine-cytosine permease", "go_ids": ["GO:0016020", "GO:0022857", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0022857:transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P"], "name": "Pur-cyt_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001249": {"description": "Acetyl-CoA biotin carboxyl carrier", "go_ids": ["GO:0003989", "GO:0006633", "GO:0009317"], "go_terms": ["GO:0003989:acetyl-CoA carboxylase activity:F", "GO:0006633:fatty acid biosynthetic process:P", "GO:0009317:acetyl-CoA carboxylase complex:C"], "name": "AcCoA_biotinCC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001250": {"description": "Mannose-6-phosphate isomerase, type I", "go_ids": ["GO:0004476", "GO:0005975", "GO:0008270"], "go_terms": ["GO:0004476:mannose-6-phosphate isomerase activity:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0008270:zinc ion binding:F"], "name": "Man6P_Isoase-1", "pathway_ids": ["PWY-5659", "PWY-3861", "PWY-6992", "PWY-7586", "PWY-3881", "PWY-7456", "R-HSA-4043916", "R-HSA-446205", "R-RNO-446205", "R-SPO-446205", "R-DDI-446205", "R-MMU-446205", "R-BTA-446205", "R-CEL-446205", "R-SCE-446205"], "pathways": ["PWY-5659:t:GDP-mannose biosynthesis", "PWY-3861:t:mannitol degradation II", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7586:t:beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation", "PWY-3881:t:mannitol biosynthesis", "PWY-7456:t:beta-(1,4)-mannan degradation", "R-HSA-4043916:r:Defective MPI causes MPI-CDG", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-RNO-446205:r:Synthesis of GDP-mannose", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-DDI-446205:r:Synthesis of GDP-mannose", "R-MMU-446205:r:Synthesis of GDP-mannose", "R-BTA-446205:r:Synthesis of GDP-mannose", "R-CEL-446205:r:Synthesis of GDP-mannose", "R-SCE-446205:r:Synthesis of GDP-mannose"], "type": "Family"}, "IPR001251": {"description": "CRAL-TRIO lipid binding domain", "go_ids": [], "go_terms": [], "name": "CRAL-TRIO_dom", "pathway_ids": ["R-RNO-9013026", "R-MMU-416476", "R-HSA-9013409", "R-HSA-9013405", "R-DDI-5218921", "R-MMU-8877627", "R-HSA-6798695", "R-DDI-2187335", "R-RNO-9013409", "R-HSA-8877627", "R-MMU-9013106", "R-MMU-9013408", "R-RNO-9013149", "R-RNO-5687128", "R-MMU-9013409", "R-MMU-9013404", "R-GGA-2187335", "R-RNO-8877627", "R-HSA-3928662", "R-DDI-2453902", "R-DME-9035034", "R-DME-9013148", "R-SCE-8980692", "R-SCE-9013149", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-HSA-2187335", "R-DDI-9013423", "R-RNO-416476", "R-RNO-193648", "R-MMU-9035034", "R-DME-9013149", "R-DME-8980692", "R-RNO-432720", "R-DDI-5658442", "R-HSA-432720", "R-HSA-416482", "R-MMU-2453902", "R-RNO-9013148", "R-RNO-418885", "R-GGA-2453902", "R-HSA-9013404", "R-SCE-9013148", "R-HSA-9008059", "R-HSA-9013149", "R-MMU-9013423", "R-SPO-8980692", "R-HSA-8980692", "R-HSA-9918438", "R-SCE-9035034", "R-HSA-5658442", "R-MMU-9013406", "R-MMU-193648", "R-HSA-9013026", "R-DRE-8980692", "R-MMU-6798695", "R-BTA-2453902", "R-DDI-8877627", "R-MMU-5687128", "R-MMU-2187335", "R-DRE-416482", "R-DRE-9013423", "R-SCE-9013423", "R-MMU-8980692", "R-RNO-8980692", "R-BTA-2187335", "R-DDI-8849471", "R-HSA-9013106", "R-HSA-418885", "R-HSA-416476", "R-MMU-9013148", "R-DRE-9013404", "R-DDI-9013149", "R-HSA-9013423", "R-RNO-416482", "R-SCE-9013406", "R-HSA-9035034", "R-HSA-9013148", "R-RNO-3928662", "R-DRE-9013149", "R-DME-9013406", "R-DME-9013409", "R-MMU-5658442", "R-RNO-9013106", "R-MMU-432720", "R-HSA-6802953", "R-HSA-525793", "R-SCE-9013409", "R-HSA-193648", "R-DRE-9013408", "R-DME-8877627", "R-HSA-9696270", "R-DRE-9013409", "R-DDI-432720", "R-SCE-9013106", "R-RNO-9013423", "R-DRE-9013148", "R-HSA-193634", "R-HSA-5687128", "R-RNO-5658442", "R-MMU-416482", "R-MMU-3928662", "R-MMU-9013026", "R-MMU-525793", "R-HSA-9013406", "R-DRE-416476", "R-DRE-193648", "R-MMU-9013149", "R-DDI-9013404", "R-MMU-9696270", "R-DME-9013423", "R-MMU-418885", "R-HSA-2453902"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-8877627:r:Vitamin E transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-2187335:r:The retinoid cycle in cones (daylight vision)", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-8877627:r:Vitamin E transport", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-GGA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-RNO-8877627:r:Vitamin E transport", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DDI-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DME-9035034:r:RHOF GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-418885:r:DCC mediated attractive signaling", "R-GGA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9918438:r:Defective visual phototransduction due to RDH5 loss of function", "R-SCE-9035034:r:RHOF GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DDI-8877627:r:Vitamin E transport", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-2187335:r:The retinoid cycle in cones (daylight vision)", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-BTA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-HSA-525793:r:Myogenesis", "R-SCE-9013409:r:RHOJ GTPase cycle", "R-HSA-193648:r:NRAGE signals death through JNK", "R-DRE-9013408:r:RHOG GTPase cycle", "R-DME-8877627:r:Vitamin E transport", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-525793:r:Myogenesis", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DRE-416476:r:G alpha (q) signalling events", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Domain"}, "IPR001253": {"description": "Translation initiation factor 1A (eIF-1A)", "go_ids": ["GO:0003743", "GO:0006413"], "go_terms": ["GO:0003743:translation initiation factor activity:F", "GO:0006413:translational initiation:P"], "name": "TIF_eIF-1A", "pathway_ids": ["R-SPO-72702", "R-SCE-156827", "R-MMU-72702", "R-DDI-72702", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-MMU-72689", "R-HSA-72706", "R-HSA-72689", "R-HSA-156827", "R-DDI-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-72649", "R-HSA-72695", "R-MMU-156827", "R-MMU-72706", "R-SCE-72649", "R-SCE-72695", "R-MMU-72695", "R-SPO-156827", "R-DDI-156827", "R-SCE-72689", "R-SPO-72689", "R-SCE-72702"], "pathways": ["R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-72649:r:Translation initiation complex formation", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72702:r:Ribosomal scanning and start codon recognition"], "type": "Family"}, "IPR001254": {"description": "Serine proteases, trypsin domain", 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"R-MMU-448706", "R-RNO-8851805", "R-CFA-6806942", "R-HSA-173736", "R-CFA-8875656", "R-HSA-140834", "R-MMU-186797", "R-HSA-8865999", "R-RNO-6798695", "R-RNO-8851907", "R-CFA-8875791", "R-HSA-9657688", "R-SSC-6798695", "R-CFA-202733", "R-HSA-9705671", "R-HSA-375276", "R-HSA-3000480", "R-RNO-1257604", "R-MMU-140834", "R-HSA-5620971", "R-BTA-159782", "R-RNO-9734091", "R-HSA-5625886", "R-MMU-173623", "R-RNO-8874081", "R-HSA-114608", "R-MMU-8874081", "R-CFA-159740", "R-HSA-8851907", "R-DME-140837", "R-RNO-5620971", "R-CFA-6811558", "R-RNO-140834", "R-MMU-159763", "R-MMU-6803157", "R-RNO-75205", "R-CFA-1433557", "R-GGA-1592389", "R-MMU-9734091", "R-HSA-1442490", "R-HSA-159763", "R-MMU-1300645", "R-GGA-140834", "R-HSA-8852405", "R-CFA-1592389", "R-MMU-977606", "R-RNO-1592389", "R-RNO-8875791", "R-RNO-2022377", "R-MMU-1257604", "R-HSA-6807004", "R-SSC-75205", "R-HSA-140875", "R-HSA-8964041", "R-BTA-174577", "R-MMU-140875", "R-DME-1474228", "R-RNO-6807004", "R-HSA-9725371", "R-BTA-166663", "R-MMU-159782", "R-MMU-8851907", "R-CFA-75205", "R-BTA-75205", "R-HSA-166662", "R-MMU-6807004", "R-HSA-8875656", "R-HSA-202733", "R-HSA-9673218", "R-CFA-140875", "R-SSC-186797", "R-HSA-186797", "R-HSA-6798695", "R-MMU-416476", "R-MMU-163125", "R-HSA-173623", "R-HSA-8875555", "R-HSA-159782", "R-MMU-159740", "R-HSA-9920588", "R-MMU-76009", "R-BTA-140837", "R-GGA-159782", "R-HSA-2168880", "R-MMU-166663", "R-BTA-6798695", "R-MMU-8875791", "R-HSA-75108", "R-MMU-375276", "R-RNO-448706", "R-HSA-1368108", "R-HSA-2855086", "R-MMU-8957275", "R-MMU-8865999", "R-CFA-2022377", "R-RNO-977606", "R-CFA-1257604", "R-HSA-9678110", "R-RNO-202733", "R-MMU-381426", "R-HSA-9673240", "R-HSA-6803157", "R-HSA-9635465", "R-HSA-9672391", "R-RNO-8852405", "R-CFA-5673001", "R-CFA-186797", "R-CFA-8851907", "R-RNO-8865999", "R-HSA-75205", "R-HSA-1266695", "R-HSA-381426", "R-RNO-5673001", "R-RNO-159740", "R-HSA-9629569", "R-MMU-2022377", "R-MMU-1474228", "R-CFA-159763", "R-MMU-2168880", "R-RNO-6803157", "R-MMU-1433557", "R-HSA-456926", "R-RNO-2168880", "R-RNO-5578768", "R-MMU-140837", "R-HSA-9694614", "R-HSA-2219530", "R-HSA-6785807", "R-XTR-6798695", "R-GGA-6798695", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-381426", "R-RNO-1462054", "R-RNO-1433557", "R-MMU-8875555", "R-SSC-173736", "R-BTA-1592389", "R-HSA-9673221", "R-MMU-6809371", "R-CFA-8875555", "R-HSA-9911233", "R-MMU-6798695", "R-MMU-8875513", "R-MMU-1462054", "R-HSA-9758881", "R-RNO-8875555", "R-HSA-1257604", "R-BTA-159763", "R-XTR-114608", "R-HSA-9672383", "R-MMU-114608", "R-XTR-173736", "R-HSA-449836", "R-HSA-6809371", "R-HSA-9725554", "R-HSA-9657689", "R-HSA-1300645", "R-BTA-173736", "R-RNO-159782", "R-SSC-114608", "R-MMU-2855086", "R-RNO-166662", "R-HSA-9925561", "R-HSA-416476", "R-MMU-3000480", "R-RNO-114608", "R-HSA-5578768", "R-RNO-8875513", "R-HSA-76009", "R-BTA-114608", "R-MMU-8852405", "R-HSA-448706", "R-HSA-977606", "R-RNO-8957275", "R-MMU-174577", "R-BTA-381426", "R-CFA-8957275", "R-HSA-174577", "R-HSA-8851805", "R-HSA-9918481", "R-BTA-159740", "R-HSA-9734091", "R-CFA-381426", "R-HSA-8875791", "R-RNO-6809371", "R-HSA-9733458", "R-HSA-1462054", "R-CFA-9758881", "R-RNO-186797", "R-MMU-75205", "R-HSA-1592389", "R-HSA-1433557", "R-SSC-977606", "R-MMU-6806942", "R-CFA-8865999", "R-SSC-6809371", "R-RNO-375276", "R-MMU-8875656", "R-HSA-8957275", "R-MMU-5620971", "R-GGA-159763", "R-HSA-2197563", "R-MMU-1442490", "R-DME-209442"], "pathways": ["R-HSA-8874081:r:MET activates PTK2 signaling", "R-SSC-2168880:r:Scavenging of heme from plasma", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9673202:r:Defective F9 variant does not activate FX", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-166662:r:Lectin pathway of complement activation", "R-GGA-140875:r:Common Pathway of Fibrin Clot Formation", "R-CFA-114608:r:Platelet degranulation", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-CFA-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CFA-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-CFA-6807004:r:Negative regulation of MET activity", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-SSC-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-BTA-977606:r:Regulation of Complement cascade", "R-RNO-6806942:r:MET Receptor Activation", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-5578768:r:Physiological factors", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-CFA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-CFA-8874081:r:MET activates PTK2 signaling", "R-CFA-8875513:r:MET interacts with TNS proteins", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-MMU-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-MMU-173736:r:Alternative complement activation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-GGA-6803157:r:Antimicrobial peptides", "R-RNO-8875656:r:MET receptor recycling", "R-MMU-448706:r:Interleukin-1 processing", "R-RNO-8851805:r:MET activates RAS signaling", "R-CFA-6806942:r:MET Receptor Activation", "R-HSA-173736:r:Alternative complement activation", "R-CFA-8875656:r:MET receptor recycling", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-186797:r:Signaling by PDGF", "R-HSA-8865999:r:MET activates PTPN11", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-8875791:r:MET activates STAT3", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-SSC-6798695:r:Neutrophil degranulation", "R-CFA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-5620971:r:Pyroptosis", "R-BTA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-CFA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-DME-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-5620971:r:Pyroptosis", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-6803157:r:Antimicrobial peptides", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-GGA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-1442490:r:Collagen degradation", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-GGA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-8852405:r:Signaling by MST1", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-SSC-75205:r:Dissolution of Fibrin Clot", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-8964041:r:LDL remodeling", "R-BTA-174577:r:Activation of C3 and C5", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-BTA-166663:r:Initial triggering of complement", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-75205:r:Dissolution of Fibrin Clot", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-HSA-166662:r:Lectin pathway of complement activation", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-8875656:r:MET receptor recycling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9673218:r:Defective F9 secretion", "R-CFA-140875:r:Common Pathway of Fibrin Clot Formation", "R-SSC-186797:r:Signaling by PDGF", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-GGA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-8875791:r:MET activates STAT3", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-448706:r:Interleukin-1 processing", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-8865999:r:MET activates PTPN11", "R-CFA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-977606:r:Regulation of Complement cascade", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9678110:r:Attachment and Entry", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9673240:r:Defective gamma-carboxylation of F9", "R-HSA-6803157:r:Antimicrobial peptides", "R-HSA-9635465:r:Suppression of apoptosis", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-RNO-8852405:r:Signaling by MST1", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-CFA-186797:r:Signaling by PDGF", "R-CFA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-8865999:r:MET activates PTPN11", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-9629569:r:Protein hydroxylation", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-CFA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-RNO-6803157:r:Antimicrobial peptides", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-RNO-5578768:r:Physiological factors", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-XTR-6798695:r:Neutrophil degranulation", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1462054:r:Alpha-defensins", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-SSC-173736:r:Alternative complement activation", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-9673221:r:Defective F9 activation", "R-MMU-6809371:r:Formation of the cornified envelope", "R-CFA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-9911233:r:Expression of NOTCH2NL genes", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-MMU-1462054:r:Alpha-defensins", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-XTR-114608:r:Platelet degranulation", "R-HSA-9672383:r:Defective factor IX causes thrombophilia", "R-MMU-114608:r:Platelet degranulation", "R-XTR-173736:r:Alternative complement activation", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-BTA-173736:r:Alternative complement activation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-SSC-114608:r:Platelet degranulation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-RNO-166662:r:Lectin pathway of complement activation", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-114608:r:Platelet degranulation", "R-HSA-5578768:r:Physiological factors", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-BTA-114608:r:Platelet degranulation", "R-MMU-8852405:r:Signaling by MST1", "R-HSA-448706:r:Interleukin-1 processing", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8875791:r:MET activates STAT3", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-1462054:r:Alpha-defensins", "R-CFA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-SSC-977606:r:Regulation of Complement cascade", "R-MMU-6806942:r:MET Receptor Activation", "R-CFA-8865999:r:MET activates PTPN11", "R-SSC-6809371:r:Formation of the cornified envelope", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-5620971:r:Pyroptosis", "R-GGA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-MMU-1442490:r:Collagen degradation", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'"], "type": "Domain"}, "IPR001257": {"description": "Parvovirus non-structural protein 1, helicase domain", "go_ids": ["GO:0019079"], "go_terms": ["GO:0019079:viral genome replication:P"], "name": "Parvovirus_NS1_helicase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001258": {"description": "NHL repeat", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "NHL_repeat", "pathway_ids": ["R-HSA-6798695", "R-HSA-114608", "R-BTA-114608", "R-DME-983168", "R-HSA-3322077", "R-HSA-877300", "R-DME-6798695", "R-HSA-3134975", "R-MMU-983168", "R-MMU-3134975", "R-MMU-6798695", "R-HSA-3785653", "R-HSA-983168", "R-RNO-983168", "R-GGA-114608", "R-MMU-114608", "R-DRE-983168"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-3322077:r:Glycogen synthesis", "R-HSA-877300:r:Interferon gamma signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Repeat"}, "IPR001259": {"description": "Proteinase inhibitor I27, calpastatin", "go_ids": [], "go_terms": [], "name": "Prot_inh_calpain", "pathway_ids": ["R-HSA-1474228", "R-HSA-8862803", "R-SSC-1474228", "R-RNO-1474228", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Repeat"}, "IPR001260": {"description": "Coproporphyrinogen III oxidase, aerobic", "go_ids": ["GO:0004109", "GO:0006779"], "go_terms": ["GO:0004109:coproporphyrinogen oxidase activity:F", "GO:0006779:porphyrin-containing compound biosynthetic process:P"], "name": "Coprogen_oxidase_aer", "pathway_ids": ["PWY-7159", "R-DDI-189451", "R-RNO-189451", "R-DME-189451", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)", "R-DDI-189451:r:Heme biosynthesis", "R-RNO-189451:r:Heme biosynthesis", "R-DME-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Family"}, "IPR001263": {"description": "Phosphoinositide 3-kinase, accessory (PIK) domain", "go_ids": [], "go_terms": [], "name": "PI3K_accessory_dom", "pathway_ids": ["R-HSA-9842640", "R-MMU-1250342", "R-HSA-9607240", "R-DDI-114604", "R-MMU-8856828", "R-BTA-198203", "R-MMU-6811558", "R-MMU-114604", "R-CEL-1660514", "R-MMU-5654720", "R-HSA-912631", "R-BTA-5673001", "R-RNO-9607240", "R-RNO-9009391", "R-BTA-8851907", "R-MMU-210993", "R-MMU-9009391", "R-MMU-1632852", "R-RNO-512988", "R-BTA-1963642", "R-BTA-5654710", "R-RNO-912631", "R-HSA-5654695", "R-MMU-201556", "R-CEL-5654695", "R-RNO-1632852", "R-BTA-4420097", "R-RNO-6811558", "R-HSA-8853659", "R-CEL-1257604", "R-BTA-6811558", "R-SCE-1660517", "R-RNO-1963642", "R-HSA-9603381", "R-SPO-5668599", "R-HSA-512988", "R-RNO-416476", "R-MMU-5673001", "R-MMU-186763", "R-HSA-114604", "R-HSA-168138", "R-RNO-210993", "R-HSA-983695", "R-HSA-5654689", "R-HSA-2424491", "R-HSA-5637810", "R-DDI-392451", "R-SCE-1632852", "R-MMU-912526", "R-CEL-1433557", "R-RNO-2730905", "R-MMU-1963642", "R-HSA-389357", "R-CEL-1660517", "R-MMU-2730905", "R-DDI-1660514", "R-CEL-6811558", "R-SPO-1483248", "R-BTA-5654689", "R-BTA-2424491", "R-HSA-9680350", "R-RNO-8851907", "R-HSA-1839117", "R-CEL-1660516", "R-SCE-1660516", "R-BTA-1660499", "R-HSA-5655253", "R-HSA-9705671", "R-RNO-9842663", "R-RNO-1257604", "R-HSA-2029485", "R-CEL-5654720", "R-HSA-9665348", "R-MMU-1483248", "R-RNO-168138", "R-BTA-5654695", "R-BTA-9927354", "R-HSA-8851907", "R-BTA-912526", "R-HSA-9028335", "R-HSA-1963642", "R-MMU-512988", "R-HSA-2730905", "R-DDI-5668599", "R-HSA-112399", "R-HSA-9027276", "R-BTA-1433557", "R-BTA-512988", "R-MMU-202424", "R-CEL-8856828", "R-HSA-5655291", "R-MMU-912631", "R-BTA-180292", "R-MMU-109704", "R-HSA-5655332", "R-DDI-1632852", "R-RNO-1250342", "R-HSA-109704", "R-SPO-1660514", "R-MMU-1257604", "R-HSA-9842663", "R-BTA-9009391", "R-RNO-5654689", "R-MMU-1660499", "R-HSA-983170", "R-HSA-9009391", "R-XTR-1660514", "R-CEL-5654689", "R-RNO-5654695", "R-RNO-1660499", "R-BTA-109704", "R-HSA-912526", "R-BTA-9013404", "R-HSA-201556", "R-BTA-1257604", "R-MMU-8851907", "R-BTA-9027276", "R-BTA-210993", "R-SPO-1660517", "R-HSA-9856530", "R-BTA-9607240", "R-MMU-5654689", "R-MMU-9013149", "R-MMU-168138", "R-HSA-9725370", "R-CEL-9009391", "R-HSA-5668599", "R-CEL-114604", "R-BTA-389357", "R-CEL-1250342", "R-MMU-416476", "R-CEL-210993", "R-MMU-9607240", "R-HSA-180292", "R-MMU-1660516", "R-HSA-8856828", "R-RNO-5654710", "R-BTA-202424", "R-SCE-1660514", "R-CEL-912631", "R-CEL-432722", "R-RNO-9013149", "R-MMU-4420097", "R-HSA-9670439", "R-RNO-9027276", "R-MMU-9013404", "R-SPO-1660516", "R-CEL-5673001", "R-RNO-912526", "R-HSA-4420097", "R-RNO-112399", "R-RNO-198203", "R-MMU-389357", "R-RNO-2029485", "R-MMU-5654695", "R-MMU-392451", "R-BTA-8853659", "R-SCE-1483248", "R-RNO-202424", "R-MMU-5668599", "R-MMU-1660514", "R-BTA-112399", "R-RNO-9013404", "R-HSA-9673767", "R-MMU-2029485", "R-DDI-1660517", "R-HSA-9664565", "R-RNO-5673001", "R-HSA-5655302", "R-RNO-9927354", "R-RNO-389357", "R-RNO-201556", "R-HSA-9927354", "R-HSA-373753", "R-MMU-1433557", "R-HSA-1483248", "R-CEL-201556", "R-MMU-180292", "R-HSA-210993", "R-RNO-8853659", "R-CEL-180292", "R-MMU-8853659", "R-HSA-2219530", "R-BTA-912631", "R-HSA-1660516", "R-DRE-1660514", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-BTA-416476", "R-HSA-9013404", "R-HSA-9013149", "R-RNO-1660517", "R-HSA-9703648", "R-HSA-5654720", "R-HSA-1632852", "R-BTA-114604", "R-MMU-9027276", "R-CEL-186763", "R-HSA-1257604", "R-MMU-1660517", "R-HSA-198203", "R-MMU-5654710", "R-RNO-4420097", "R-SPO-1632852", "R-HSA-9679504", "R-HSA-1660517", "R-CEL-392451", "R-DDI-1660499", "R-MMU-432722", "R-BTA-5654720", "R-CEL-1632852", "R-RNO-109704", "R-CEL-5668599", "R-HSA-416476", "R-HSA-1250342", "R-RNO-1660514", "R-HSA-1660499", "R-CEL-416476", "R-CEL-9013149", "R-MMU-9842663", "R-RNO-5668599", "R-BTA-186763", "R-MMU-198203", "R-HSA-9673770", "R-BTA-201556", "R-RNO-1660516", "R-HSA-1236382", "R-HSA-9920951", "R-HSA-432722", "R-CEL-5654710", "R-BTA-2029485", "R-HSA-9694676", "R-DDI-1660516", "R-BTA-1250342", "R-MMU-983695", "R-RNO-180292", "R-HSA-1660514", "R-HSA-1433557", "R-MMU-112399", "R-HSA-186763", "R-RNO-114604", "R-HSA-9703465", "R-BTA-2730905", "R-RNO-2424491", "R-CEL-4420097", "R-RNO-1483248", "R-MMU-9927354", "R-CEL-1963642", "R-HSA-5654710", "R-RNO-5654720", "R-CEL-1660499", "R-MMU-2424491", "R-SCE-5668599", "R-HSA-202424", "R-RNO-186763", "R-HSA-392451"], "pathways": ["R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-BTA-198203:r:PI3K/AKT activation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-912631:r:Regulation of signaling by CBL", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-RNO-9607240:r:FLT3 Signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-210993:r:Tie2 Signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-1632852:r:Macroautophagy", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-912631:r:Regulation of signaling by CBL", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-201556:r:Signaling by ALK", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-RNO-1632852:r:Macroautophagy", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SCE-1632852:r:Macroautophagy", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-BTA-2424491:r:DAP12 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DDI-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-112399:r:IRS-mediated signalling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-912631:r:Regulation of signaling by CBL", "R-BTA-180292:r:GAB1 signalosome", "R-MMU-109704:r:PI3K Cascade", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DDI-1632852:r:Macroautophagy", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-109704:r:PI3K Cascade", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-XTR-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-109704:r:PI3K Cascade", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-201556:r:Signaling by ALK", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-210993:r:Tie2 Signaling", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9856530:r:High laminar flow 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complex", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-3371378:r:Regulation by c-FLIP", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-XTR-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-SSC-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DRE-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DRE-209560:r:NF-kB is activated and signals survival", "R-SSC-5689880:r:Ub-specific processing proteases", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", 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"R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-202424:r:Downstream TCR signaling", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Domain"}, "IPR001296": {"description": "Glycosyl transferase, family 1", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "Glyco_trans_1", "pathway_ids": ["R-SCE-446193", "R-SPO-162710", "R-MMU-446193", "R-HSA-162710", "R-HSA-4551295", "R-DDI-446193", "R-MMU-162710", "R-HSA-4549349", "R-SPO-446193", "R-HSA-4549380", "R-MTU-879299", "R-HSA-446193"], "pathways": ["R-SCE-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-4551295:r:Defective ALG11 causes CDG-1p", "R-DDI-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-4549349:r:Defective ALG2 causes CDG-1i", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-4549380:r:Defective ALG1 causes CDG-1k", "R-MTU-879299:r:Mycothiol biosynthesis", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Domain"}, "IPR001297": {"description": "Phycobilisome linker domain", "go_ids": ["GO:0015979", "GO:0030089"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0030089:phycobilisome:C"], "name": "PBS_linker_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001298": {"description": "Filamin/ABP280 repeat", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Filamin/ABP280_rpt", "pathway_ids": ["R-MMU-446353", "R-HSA-8983711", "R-RNO-446353", "R-MMU-430116", "R-DME-114608", "R-HSA-430116", "R-DME-5627123", "R-HSA-983168", "R-HSA-1169408", "R-MMU-1169408", "R-DRE-983168", "R-HSA-114608", "R-HSA-5627123", "R-HSA-446353", "R-HSA-877300", "R-MMU-983168", "R-MMU-5627123", "R-DME-446353", "R-RNO-983168", "R-MMU-114608"], "pathways": ["R-MMU-446353:r:Cell-extracellular matrix interactions", "R-HSA-8983711:r:OAS antiviral response", "R-RNO-446353:r:Cell-extracellular matrix interactions", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-DME-114608:r:Platelet degranulation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-114608:r:Platelet degranulation"], "type": "Repeat"}, "IPR001299": {"description": "Ependymin", "go_ids": ["GO:0005509", "GO:0005576", "GO:0007160"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0005576:extracellular region:C", "GO:0007160:cell-matrix adhesion:P"], "name": "Ependymin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001300": {"description": "Peptidase C2, calpain, catalytic domain", "go_ids": ["GO:0004198", "GO:0006508"], "go_terms": ["GO:0004198:calcium-dependent cysteine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_C2_calpain_cat", "pathway_ids": ["R-HSA-1474228", "R-HSA-6798695", "R-RNO-6798695", "R-SSC-6798695", "R-HSA-6809371", "R-MMU-9856530", "R-DME-6798695", "R-RNO-1474228", "R-CEL-6798695", "R-BTA-1474228", "R-HSA-8862803", "R-SSC-1474228", "R-RNO-9860927", "R-RNO-9856530", "R-BTA-9860927", "R-SSC-6809371", 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"R-DME-1482922", "R-HSA-166662", "R-RNO-2022854", "R-BTA-5683826", "R-BTA-1482922", "R-RNO-166016", "R-HSA-5687868", "R-HSA-202733", "R-HSA-391160", "R-HSA-5688849", "R-HSA-3595174", "R-HSA-6798695", "R-CFA-2424491", "R-HSA-9920588", "R-MMU-5607764", "R-HSA-166016", "R-CEL-6798695", "R-RNO-5621480", "R-BTA-1482801", "R-BTA-6798695", "R-SSC-5686938", "R-SSC-1474228", "R-MMU-8957275", "R-DME-9749641", "R-MMU-3000178", "R-RNO-202733", "R-MMU-381426", "R-HSA-6803157", "R-BTA-2022870", "R-BTA-391160", "R-HSA-5621480", "R-RNO-3000178", "R-DME-1482925", "R-HSA-6783783", "R-HSA-381426", "R-MMU-2022923", "R-MMU-446203", "R-SSC-3000178", "R-MMU-1474228", "R-HSA-2024101", "R-RNO-6803157", "R-BTA-198933", "R-MMU-5620916", "R-DRE-3000480", "R-RNO-198933", "R-MMU-5621575", "R-MMU-166016", "R-HSA-2172127", "R-CEL-1482839", "R-RNO-446203", "R-SSC-166016", "R-BTA-1482925", "R-HSA-6785807", "R-MMU-2022854", "R-BTA-166016", "R-HSA-3560801", "R-RNO-381426", "R-MMU-198933", "R-HSA-2022854", "R-HSA-5688890", "R-HSA-5683826", "R-SSC-391160", "R-HSA-3656243", "R-HSA-4420332", "R-MMU-6798695", "R-HSA-198933", "R-MMU-416700", "R-MMU-114608", "R-GGA-2132263", "R-MMU-2022870", "R-BTA-6803157", "R-BTA-1482788", "R-DME-1482839", "R-RNO-166662", "R-BTA-3000178", "R-HSA-9925561", "R-MMU-3000480", "R-SSC-5683826", "R-RNO-114608", "R-BTA-202733", "R-CEL-6803157", "R-HSA-1482922", "R-HSA-416700", "R-RNO-8957275", "R-RNO-2024101", "R-HSA-5621575", "R-BTA-381426", "R-HSA-9833110", "R-MMU-1482925", "R-HSA-5607764", "R-BTA-2024101", "R-RNO-1236978", "R-MMU-5683826", "R-HSA-446203", "R-CEL-9619665", "R-CEL-1482925", "R-HSA-1236978", "R-CEL-1483166", "R-RNO-5683826", "R-BTA-5686938", "R-DME-1482801", "R-RNO-1971475", "R-MMU-1482922", "R-RNO-2424491", "R-HSA-9692916", "R-BTA-5621480", "R-MMU-2424491", "R-HSA-8957275", "R-BTA-2022923", "R-HSA-2197563", "R-CEL-1482788", "R-MMU-1236978", "R-MMU-1971475", "R-MMU-1482801", "R-HSA-9637628"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-DME-1482788:r:Acyl chain remodelling of PC", "R-DME-6803157:r:Antimicrobial peptides", "R-MMU-166662:r:Lectin pathway of complement activation", "R-GGA-2132270:r:Lectin-mediated initiation of complement cascade", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-HSA-166663:r:Initial triggering of complement", "R-CEL-1482801:r:Acyl chain remodelling of PS", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-CEL-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-DME-210991:r:Basigin interactions", "R-HSA-2424491:r:DAP12 signaling", "R-SSC-2022857:r:Keratan sulfate degradation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-2022857:r:Keratan sulfate degradation", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-2024101:r:CS/DS degradation", "R-CEL-1482922:r:Acyl chain remodelling of PI", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-166662:r:Lectin pathway of complement activation", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-CFA-2172127:r:DAP12 interactions", "R-SSC-6798695:r:Neutrophil degranulation", "R-RNO-2172127:r:DAP12 interactions", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-BTA-3000480:r:Scavenging by Class A Receptors", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-HSA-1483166:r:Synthesis of PA", "R-MMU-2172127:r:DAP12 interactions", "R-HSA-373760:r:L1CAM interactions", "R-DME-1483166:r:Synthesis of PA", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-HSA-114608:r:Platelet degranulation", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-BTA-1483166:r:Synthesis of PA", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-MMU-5621480:r:Dectin-2 family", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-DRE-166662:r:Lectin pathway of complement activation", "R-HSA-9707616:r:Heme signaling", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-2022857:r:Keratan sulfate degradation", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-DME-1482922:r:Acyl chain remodelling of PI", "R-HSA-166662:r:Lectin pathway of complement activation", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-BTA-5683826:r:Surfactant metabolism", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-5687868:r:Defective SFTPA2 causes IPF", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-HSA-6798695:r:Neutrophil degranulation", "R-CFA-2424491:r:DAP12 signaling", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-6798695:r:Neutrophil degranulation", "R-RNO-5621480:r:Dectin-2 family", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-5686938:r:Regulation of TLR by endogenous ligand", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-DME-9749641:r:Aspirin ADME", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-HSA-5621480:r:Dectin-2 family", "R-RNO-3000178:r:ECM proteoglycans", "R-DME-1482925:r:Acyl chain remodelling of PG", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-SSC-3000178:r:ECM proteoglycans", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-2024101:r:CS/DS degradation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-3000480:r:Scavenging by Class A Receptors", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-2172127:r:DAP12 interactions", "R-CEL-1482839:r:Acyl chain remodelling of PE", "R-RNO-446203:r:Asparagine N-linked glycosylation", "R-SSC-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-114608:r:Platelet degranulation", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-BTA-6803157:r:Antimicrobial peptides", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-DME-1482839:r:Acyl chain remodelling of PE", "R-RNO-166662:r:Lectin pathway of complement activation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-SSC-5683826:r:Surfactant metabolism", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-CEL-6803157:r:Antimicrobial peptides", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-1482925:r:Acyl chain remodelling of PG", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-1483166:r:Synthesis of PA", "R-RNO-5683826:r:Surfactant metabolism", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-1482801:r:Acyl chain remodelling of PS", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-5621480:r:Dectin-2 family", "R-MMU-2424491:r:DAP12 signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-CEL-1482788:r:Acyl chain remodelling of PC", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-9637628:r:Modulation by Mtb of host immune system"], "type": "Domain"}, "IPR001305": {"description": "Heat shock protein DnaJ, cysteine-rich domain", "go_ids": ["GO:0031072"], "go_terms": ["GO:0031072:heat shock protein binding:F"], "name": "HSP_DnaJ_Cys-rich_dom", "pathway_ids": ["R-SPO-3371497", "R-SCE-3371497", "R-DDI-3371497", "R-MMU-9841251", "R-SPO-9841251", "R-HSA-9841251", "R-BTA-3371497", "R-HSA-9918487", "R-RNO-3371497", "R-SCE-9841251", "R-HSA-3371497", "R-RNO-9841251", "R-BTA-9841251", "R-MMU-3371497"], "pathways": ["R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DDI-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "type": "Domain"}, "IPR001308": {"description": "Electron transfer flavoprotein alpha subunit/FixB", "go_ids": ["GO:0009055", "GO:0050660"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "ETF_a/FixB", "pathway_ids": ["R-DDI-611105", "R-RNO-611105", "R-HSA-611105", "R-SPO-611105", "R-SCE-611105", "R-DME-611105", "R-CEL-611105", "R-MMU-611105"], "pathways": ["R-DDI-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-DME-611105:r:Respiratory electron transport", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR001310": {"description": "Histidine triad (HIT) protein", "go_ids": [], "go_terms": [], "name": "Histidine_triad_HIT", "pathway_ids": ["R-MMU-9856649", "R-HSA-9013405", "R-RNO-9825892", "R-MMU-9824594", "R-HSA-9824594", "R-RNO-9856649", "R-CEL-9825892", "R-HSA-9856649", "R-CEL-9824594", "R-CEL-9856649", "R-RNO-9824594", "R-MMU-9825892", "R-HSA-9825892"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-MMU-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "type": "Family"}, "IPR001312": {"description": "Hexokinase", "go_ids": ["GO:0005975", "GO:0004396", "GO:0005536", "GO:0005524", "GO:0001678"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0004396:hexokinase activity:F", "GO:0005536:D-glucose binding:F", "GO:0005524:ATP binding:F", "GO:0001678:intracellular glucose homeostasis:P"], "name": "Hexokinase", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-MMU-70171", "R-SPO-6798695", "R-SCE-70171", "R-DME-446205", "R-HSA-5619073", "R-DME-6798695", "R-SCE-6798695", "R-DME-70171", "R-HSA-210745", "R-HSA-170822", "R-MMU-170822", "R-DME-170822", "R-RNO-70171", "R-HSA-446205", "R-HSA-9615017", "R-SCE-170822", "R-RNO-170822", "R-SPO-446205", "R-SPO-170822", "R-HSA-5619107", "R-MMU-6798695", "R-SCE-446205", "R-HSA-5619056", "R-HSA-70171", "R-SPO-70171"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-70171:r:Glycolysis", "R-SPO-6798695:r:Neutrophil degranulation", "R-SCE-70171:r:Glycolysis", "R-DME-446205:r:Synthesis of GDP-mannose", "R-HSA-5619073:r:Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-70171:r:Glycolysis", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DME-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-70171:r:Glycolysis", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SCE-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-SPO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-446205:r:Synthesis of GDP-mannose", "R-HSA-5619056:r:Defective HK1 causes hexokinase deficiency (HK deficiency)", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis"], "type": "Family"}, "IPR001313": {"description": "Pumilio RNA-binding repeat", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Pumilio_RNA-bd_rpt", "pathway_ids": ["R-DME-432722", "R-GGA-432722", "R-HSA-432722", "R-HSA-8951664", "R-MMU-432722"], "pathways": ["R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-GGA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-8951664:r:Neddylation", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Repeat"}, "IPR001315": {"description": "CARD domain", "go_ids": ["GO:0042981"], "go_terms": ["GO:0042981:regulation of apoptotic process:P"], "name": "CARD", "pathway_ids": ["R-HSA-9020702", "R-HSA-168638", "R-RNO-9968551", "R-HSA-5689880", "R-MMU-198323", "R-DRE-111458", "R-SSC-5357905", "R-HSA-9960519", "R-MMU-418889", "R-MMU-5689896", "R-RNO-8866654", "R-CFA-5676594", "R-BTA-450321", "R-MMU-5689880", "R-CEL-9948001", "R-BTA-9948001", "R-MMU-9013420", "R-HSA-168927", "R-CFA-937041", "R-MMU-5668541", "R-HSA-450302", "R-HSA-937041", "R-HSA-111463", "R-DRE-9968551", "R-HSA-844455", "R-HSA-9956593", "R-MMU-8866654", "R-RNO-6803207", "R-HSA-5674400", "R-MMU-9948011", "R-SSC-5675482", "R-HSA-9660826", "R-RNO-205025", "R-MMU-111458", "R-MMU-450321", "R-HSA-9948001", "R-HSA-9696264", "R-HSA-8866654", "R-HSA-9008059", "R-MMU-448706", "R-RNO-9627069", "R-MMU-5357905", "R-DRE-9953170", "R-DRE-9948001", "R-MMU-9696264", "R-RNO-6798695", "R-HSA-9705671", "R-MMU-450302", "R-HSA-5620971", "R-RNO-844455", "R-MMU-5357956", "R-DRE-9627069", "R-HSA-5357905", "R-MMU-9627069", "R-RNO-5620971", "R-BTA-209543", "R-MMU-6803207", "R-CFA-168638", "R-HSA-9627069", "R-CFA-5357956", "R-MMU-111465", "R-MMU-202424", "R-MMU-5660668", "R-HSA-9696270", "R-HSA-6803207", "R-MMU-5675482", "R-MMU-9013424", "R-MMU-1169091", "R-RNO-111459", "R-DRE-844456", "R-SSC-937041", "R-HSA-5357956", "R-MMU-9948001", "R-HSA-9948011", "R-HSA-111465", "R-HSA-205025", "R-MMU-9696273", "R-CEL-198323", "R-HSA-844615", "R-CFA-5357905", "R-MMU-937041", "R-HSA-6798695", "R-BTA-9948011", "R-MMU-5607764", "R-HSA-5689896", "R-SSC-5357786", "R-MMU-844455", "R-BTA-202424", "R-BTA-9960525", "R-CEL-9948011", "R-HSA-9013424", "R-RNO-448706", "R-HSA-450321", "R-MMU-111459", "R-BTA-9960519", "R-RNO-111458", "R-BTA-5620971", "R-DRE-6798695", "R-RNO-202424", "R-DRE-5689901", "R-HSA-111459", "R-MMU-209543", "R-HSA-5675482", "R-CFA-5357786", "R-HSA-111458", "R-HSA-5357786", "R-SSC-5676594", "R-HSA-1169091", "R-MMU-2871837", "R-MMU-6798695", "R-RNO-168638", "R-HSA-9968551", "R-HSA-844456", "R-HSA-445989", "R-DRE-844455", "R-MMU-5676594", "R-MMU-9960525", "R-CFA-5668541", "R-HSA-9960525", "R-HSA-209543", "R-HSA-5676594", "R-HSA-418889", "R-CFA-5675482", "R-HSA-8953750", "R-MMU-205025", "R-HSA-198323", "R-CFA-5689880", "R-HSA-2871837", "R-HSA-448706", "R-HSA-5660668", "R-MMU-9960519", "R-SSC-5689880", "R-MMU-168638", "R-BTA-168638", "R-HSA-5607764", "R-SSC-5668541", "R-MMU-5357786", "R-HSA-9013420", "R-BTA-5689896", "R-DRE-111459", "R-HSA-111464", "R-MMU-844456", "R-SSC-5357956", "R-HSA-5213460", "R-HSA-5668541", "R-RNO-5607764", "R-BTA-450302", "R-RNO-1169091", "R-HSA-9692916", "R-MMU-5620971", "R-MMU-9696270", "R-HSA-202424", "R-HSA-9696273", "R-RNO-2871837", "R-HSA-844623"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-RNO-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-111458:r:Formation of apoptosome", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9960519:r:CASP4-mediated substrate cleavage", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CFA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-9948001:r:CASP4 inflammasome assembly", "R-BTA-9948001:r:CASP4 inflammasome assembly", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-CFA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-DRE-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-844455:r:The NLRP1 inflammasome", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-9948011:r:CASP5 inflammasome assembly", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-205025:r:NADE modulates death signalling", "R-MMU-111458:r:Formation of apoptosome", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-448706:r:Interleukin-1 processing", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-DRE-9953170:r:GBP-mediated host defense", "R-DRE-9948001:r:CASP4 inflammasome assembly", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-5620971:r:Pyroptosis", "R-RNO-844455:r:The NLRP1 inflammasome", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-RNO-5620971:r:Pyroptosis", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DRE-844456:r:The NLRP3 inflammasome", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-9948001:r:CASP4 inflammasome assembly", "R-HSA-9948011:r:CASP5 inflammasome assembly", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-205025:r:NADE modulates death signalling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-844615:r:The AIM2 inflammasome", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-9948011:r:CASP5 inflammasome assembly", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-SSC-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-844455:r:The NLRP1 inflammasome", "R-BTA-202424:r:Downstream TCR signaling", "R-BTA-9960525:r:CASP5-mediated substrate cleavage", "R-CEL-9948011:r:CASP5 inflammasome assembly", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-448706:r:Interleukin-1 processing", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-BTA-9960519:r:CASP4-mediated substrate cleavage", "R-RNO-111458:r:Formation of apoptosome", "R-BTA-5620971:r:Pyroptosis", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-202424:r:Downstream TCR signaling", "R-DRE-5689901:r:Metalloprotease DUBs", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-CFA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-SSC-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-844455:r:The NLRP1 inflammasome", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-205025:r:NADE modulates death signalling", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-CFA-5689880:r:Ub-specific processing proteases", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-448706:r:Interleukin-1 processing", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-SSC-5689880:r:Ub-specific processing proteases", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-9013420:r:RHOU GTPase cycle", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-DRE-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-MMU-844456:r:The NLRP3 inflammasome", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-5620971:r:Pyroptosis", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR001316": {"description": "Peptidase S1A, streptogrisin", "go_ids": ["GO:0004252", "GO:0006508"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_S1A_streptogrisin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001319": {"description": "Nuclear transition protein 1", "go_ids": ["GO:0000786", "GO:0003677", "GO:0005634", "GO:0007283"], "go_terms": ["GO:0000786:nucleosome:C", "GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0007283:spermatogenesis:P"], "name": "Nuclear_transition_prot1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001320": {"description": "Ionotropic glutamate receptor, C-terminal", "go_ids": ["GO:0015276", "GO:0016020"], "go_terms": ["GO:0015276:ligand-gated monoatomic ion channel activity:F", "GO:0016020:membrane:C"], "name": "Iontro_rcpt_C", "pathway_ids": ["R-HSA-9022699", "R-CFA-438066", "R-MMU-451307", "R-MMU-399719", "R-RNO-416993", "R-MMU-204005", "R-DME-399710", "R-RNO-451307", "R-MMU-451308", "R-MMU-9609736", "R-MMU-5694530", "R-CEL-438066", "R-HSA-442982", "R-MMU-399710", "R-HSA-5694530", "R-HSA-3928662", "R-CEL-451307", "R-CFA-8849932", "R-CEL-451308", "R-CEL-204005", "R-CFA-5673001", "R-DME-500657", "R-RNO-5673001", "R-MMU-5673001", "R-DME-438066", "R-DME-451307", "R-CEL-5694530", "R-HSA-451308", "R-MMU-8849932", "R-MMU-438066", "R-DME-3928662", "R-RNO-399710", "R-RNO-438066", "R-HSA-5673001", "R-CFA-3928662", "R-HSA-204005", "R-RNO-500657", "R-HSA-9620244", "R-CEL-399710", "R-RNO-8849932", "R-HSA-9609736", "R-CEL-8849932", "R-DME-9609736", "R-CFA-9609736", "R-DME-416993", "R-HSA-451307", "R-HSA-8849932", "R-HSA-399710", "R-CEL-500657", "R-HSA-6794361", "R-HSA-500657", "R-RNO-3928662", "R-RNO-451308", "R-HSA-9617324", "R-MMU-416993", "R-HSA-416993", "R-RNO-5694530", "R-HSA-399719", "R-MMU-500657", "R-RNO-399719", "R-HSA-9032500", "R-RNO-204005", "R-RNO-9609736", "R-DME-451308", "R-DME-8849932", "R-HSA-438066", "R-MMU-3928662"], "pathways": ["R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-451307:r:Activation of Na-permeable kainate receptors", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DME-399710:r:Activation of AMPA receptors", "R-RNO-451307:r:Activation of Na-permeable kainate receptors", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-MMU-399710:r:Activation of AMPA receptors", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-451307:r:Activation of Na-permeable kainate receptors", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-DME-500657:r:Presynaptic function of Kainate receptors", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-451307:r:Activation of Na-permeable kainate receptors", "R-CEL-5694530:r:Cargo concentration in the ER", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-RNO-399710:r:Activation of AMPA receptors", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-500657:r:Presynaptic function of Kainate receptors", "R-HSA-9620244:r:Long-term potentiation", "R-CEL-399710:r:Activation of AMPA receptors", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DME-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-451307:r:Activation of Na-permeable kainate receptors", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-399710:r:Activation of AMPA receptors", "R-CEL-500657:r:Presynaptic function of Kainate receptors", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-3928662:r:EPHB-mediated forward signaling"], "type": "Domain"}, "IPR001322": {"description": "Lamin tail domain", "go_ids": [], "go_terms": [], "name": "Lamin_tail_dom", "pathway_ids": ["R-HSA-9013405", "R-RNO-2995383", "R-HSA-6802952", "R-RNO-352238", "R-RNO-9035034", "R-CEL-4419969", "R-HSA-8862803", "R-RNO-2559584", "R-HSA-1221632", "R-MMU-2559584", "R-DME-352238", "R-CEL-9035034", "R-SSC-4419969", "R-DME-9035034", "R-MMU-2980766", "R-HSA-9035034", "R-CEL-2559584", "R-HSA-352238", "R-HSA-2559584", "R-SSC-2995383", "R-SSC-2980766", "R-MMU-2995383", "R-RNO-2980766", "R-DME-4419969", "R-SSC-352238", "R-MMU-9035034", "R-HSA-381038", "R-HSA-8950505", "R-HSA-2995383", "R-MMU-352238", "R-HSA-4419969", "R-HSA-2980766", "R-MMU-4419969", "R-RNO-4419969"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-352238:r:Breakdown of the nuclear lamina", "R-RNO-9035034:r:RHOF GTPase cycle", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-DME-352238:r:Breakdown of the nuclear lamina", "R-CEL-9035034:r:RHOF GTPase cycle", "R-SSC-4419969:r:Depolymerization of the Nuclear Lamina", "R-DME-9035034:r:RHOF GTPase cycle", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-HSA-9035034:r:RHOF GTPase cycle", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-352238:r:Breakdown of the nuclear lamina", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-SSC-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SSC-2980766:r:Nuclear Envelope Breakdown", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-2980766:r:Nuclear Envelope Breakdown", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-SSC-352238:r:Breakdown of the nuclear lamina", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-352238:r:Breakdown of the nuclear lamina", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina"], "type": "Domain"}, "IPR001323": {"description": "Erythropoietin/thrombopoietin", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "EPO_TPO", "pathway_ids": ["R-HSA-76009", "R-SSC-9027276", "R-HSA-1234158", "R-HSA-9006335", "R-BTA-9027276", "R-HSA-9027277", "R-MMU-9027276", "R-DRE-9027276", "R-BTA-9027284", "R-SSC-9027284", "R-HSA-9027284", "R-RNO-9027276", "R-HSA-9027283", "R-HSA-9027276", "R-RNO-9027284", "R-MMU-9027284"], "pathways": ["R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-DRE-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-9027284:r:Erythropoietin activates RAS"], "type": "Family"}, "IPR001325": {"description": "Interleukin-4/interleukin-13", "go_ids": ["GO:0005126", "GO:0005576", "GO:0006955"], "go_terms": ["GO:0005126:cytokine receptor binding:F", "GO:0005576:extracellular region:C", "GO:0006955:immune response:P"], "name": "IL-4/IL-13", "pathway_ids": ["R-CFA-6785807", "R-RNO-6785807", "R-HSA-9012546", "R-SSC-6785807", "R-HSA-6785807", "R-BTA-6785807", "R-MMU-6785807"], "pathways": ["R-CFA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9012546:r:Interleukin-18 signaling", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-BTA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling"], "type": "Family"}, "IPR001328": {"description": "Peptidyl-tRNA hydrolase", "go_ids": ["GO:0004045"], "go_terms": ["GO:0004045:peptidyl-tRNA hydrolase activity:F"], "name": "Pept_tRNA_hydro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001330": {"description": "Prenyltransferase alpha-alpha toroid domain", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Prenyltrans", "pathway_ids": ["R-SPO-6803205", "R-CEL-6803205", "R-BTA-8873719", "R-RNO-9953170", "R-MMU-6803205", "R-DDI-8873719", "R-HSA-2514859", "R-HSA-8873719", "R-MMU-9648002", "R-BTA-9648002", "R-SCE-8873719", "R-SCE-6803205", "R-BTA-2514859", "R-HSA-6803205", "R-HSA-9679191", "R-DDI-9648002", "R-MMU-9953170", "R-MMU-8873719", "R-BTA-6803205", "R-BTA-9953170", "R-RNO-6803205", "R-RNO-8873719", "R-SPO-9648002", "R-CEL-8873719", "R-MMU-2514859", "R-SPO-8873719", "R-RNO-9648002", "R-DDI-6803205", "R-HSA-9648002", "R-DDI-9953170", "R-RNO-2514859", "R-HSA-9953170", "R-SCE-9648002"], "pathways": ["R-SPO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-CEL-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-BTA-8873719:r:RAB geranylgeranylation", "R-RNO-9953170:r:GBP-mediated host defense", "R-MMU-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DDI-8873719:r:RAB geranylgeranylation", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-8873719:r:RAB geranylgeranylation", "R-MMU-9648002:r:RAS processing", "R-BTA-9648002:r:RAS processing", "R-SCE-8873719:r:RAB geranylgeranylation", "R-SCE-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DDI-9648002:r:RAS processing", "R-MMU-9953170:r:GBP-mediated host defense", "R-MMU-8873719:r:RAB geranylgeranylation", "R-BTA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-BTA-9953170:r:GBP-mediated host defense", "R-RNO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-RNO-8873719:r:RAB geranylgeranylation", "R-SPO-9648002:r:RAS processing", "R-CEL-8873719:r:RAB geranylgeranylation", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SPO-8873719:r:RAB geranylgeranylation", "R-RNO-9648002:r:RAS processing", "R-DDI-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-9648002:r:RAS processing", "R-DDI-9953170:r:GBP-mediated host defense", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-9953170:r:GBP-mediated host defense", "R-SCE-9648002:r:RAS processing"], "type": "Domain"}, "IPR001332": {"description": "Arterivirus GP5 envelope glycoprotein", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Arteri_GP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001333": {"description": "Peptidase M32, carboxypeptidase Taq", "go_ids": ["GO:0004181", "GO:0006508"], "go_terms": ["GO:0004181:metallocarboxypeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_M32_Taq", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001334": {"description": "E6 early regulatory protein", "go_ids": [], "go_terms": [], "name": "E6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001337": {"description": "Tobacco mosaic virus-like, coat protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "TMV-like_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001338": {"description": "Class I Hydrophobin", "go_ids": ["GO:0005199", "GO:0009277"], "go_terms": ["GO:0005199:structural constituent of cell wall:F", "GO:0009277:fungal-type cell wall:C"], "name": "Class_I_Hydrophobin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001339": {"description": "mRNA capping enzyme, adenylation domain", "go_ids": ["GO:0005524", "GO:0004484", "GO:0006370"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0004484:mRNA guanylyltransferase activity:F", "GO:0006370:7-methylguanosine mRNA capping:P"], "name": "mRNA_cap_enzyme_adenylation", "pathway_ids": ["PWY-7375", "R-SPO-77075", "R-MMU-77075", "R-SCE-77075", "R-HSA-167160", "R-SCE-72086", "R-DRE-72086", "R-HSA-77075", "R-MMU-72086", "R-HSA-72086", "R-SPO-72086", "R-CEL-72086", "R-CEL-77075", "R-DRE-77075"], "pathways": ["PWY-7375:t:mRNA capping I", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-SPO-72086:r:mRNA Capping", "R-CEL-72086:r:mRNA Capping", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE"], "type": "Domain"}, "IPR001341": {"description": "Aspartate kinase", "go_ids": ["GO:0004072", "GO:0008652"], "go_terms": ["GO:0004072:aspartate kinase activity:F", "GO:0008652:amino acid biosynthetic process:P"], "name": "Asp_kinase", "pathway_ids": ["PWY-7977", "PWY-6562", "PWY-2942", "PWY-8088", "PWY-8296", "PWY-6559", "PWY-6160", "PWY-5097", "PWY-7153", "PWY-8179", "PWY-2941"], "pathways": ["PWY-7977:t:L-methionine biosynthesis IV", "PWY-6562:t:norspermidine biosynthesis", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8088:t:dipicolinate biosynthesis", "PWY-8296:t:cremeomycin biosynthesis", "PWY-6559:t:spermidine biosynthesis II", "PWY-6160:t:3-dehydroquinate biosynthesis II (archaea)", "PWY-5097:t:L-lysine biosynthesis VI", "PWY-7153:t:grixazone biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Family"}, "IPR001342": {"description": "Homoserine dehydrogenase, catalytic", "go_ids": ["GO:0006520"], "go_terms": ["GO:0006520:amino acid metabolic process:P"], "name": "HDH_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001343": {"description": "RTX calcium-binding nonapeptide repeat", "go_ids": ["GO:0005509"], "go_terms": ["GO:0005509:calcium ion binding:F"], "name": "Hemolysn_Ca-bd", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Repeat"}, "IPR001344": {"description": "Chlorophyll A-B binding protein, plant and chromista", "go_ids": ["GO:0009765", "GO:0016020"], "go_terms": ["GO:0009765:photosynthesis, light harvesting:P", "GO:0016020:membrane:C"], "name": "Chloro_AB-bd_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001346": {"description": "Interferon regulatory factor, DNA-binding domain", "go_ids": ["GO:0000976"], "go_terms": ["GO:0000976:transcription cis-regulatory region binding:F"], "name": "Interferon_reg_fact_DNA-bd_dom", "pathway_ids": ["R-HSA-9833109", "R-SSC-3134973", "R-HSA-1606341", "R-GGA-933541", "R-MMU-933541", "R-HSA-9705671", "R-HSA-168928", "R-SSC-936964", "R-SSC-3270619", "R-BTA-918233", "R-HSA-5620971", "R-HSA-936440", "R-MMU-9013973", "R-HSA-1169408", "R-MMU-3134963", "R-HSA-936964", "R-HSA-918233", "R-SSC-3134975", "R-HSA-3134963", "R-BTA-3270619", "R-BTA-936440", "R-MMU-918233", "R-SSC-918233", "R-SSC-1169408", "R-BTA-936964", "R-GGA-434136", "R-MMU-975110", "R-MMU-909733", "R-GGA-1227882", "R-GGA-936964", "R-MMU-936964", "R-BTA-1606341", "R-HSA-3270619", "R-GGA-975110", "R-MMU-168928", "R-MMU-3270619", "R-SSC-933541", "R-HSA-9013973", "R-SSC-1606341", "R-GGA-9013973", "R-HSA-983231", "R-MMU-3134975", "R-BTA-3134973", "R-GGA-3134963", "R-MMU-3134973", "R-HSA-6785807", "R-MMU-1169408", "R-BTA-933541", "R-MMU-9860276", "R-HSA-9824585", "R-BTA-9013973", "R-SSC-168928", "R-HSA-9860276", "R-HSA-9725371", "R-HSA-933541", "R-HSA-9909649", "R-SSC-9013973", "R-HSA-909733", "R-HSA-877300", "R-HSA-9692916", "R-HSA-3134975", "R-BTA-168928", "R-SSC-936440", "R-MMU-936440", "R-HSA-975110", "R-HSA-3134973", "R-BTA-1169408", "R-GGA-433819", "R-MMU-1606341"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-SSC-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-GGA-933541:r:TRAF6 mediated IRF7 activation", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SSC-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-SSC-3270619:r:IRF3-mediated induction of type I IFN", "R-BTA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5620971:r:Pyroptosis", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-SSC-3134975:r:Regulation of innate immune responses to cytosolic DNA", 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"R-HSA-8948751", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-HSA-187577", "R-DRE-9912633", "R-DDI-9755511", "R-DME-382556", "R-DME-5610780", "R-SSC-174178", "R-SSC-8951664", "R-SPO-1236974", "R-DME-195253", "R-MMU-69601", "R-SSC-174084", "R-CEL-1236974", "R-DRE-8852276", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-SSC-5658442", "R-HSA-5607764", "R-DRE-5687128", "R-CEL-1236978", "R-RNO-4608870", "R-SSC-9954709", "R-SSC-8852276", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-CEL-68949", "R-DME-5632684", "R-HSA-5687128", "R-DME-432395", "R-MMU-1236974", "R-SSC-4608870", "R-DDI-174178"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-DRE-4641258:r:Degradation of DVL", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SCE-5689880:r:Ub-specific processing proteases", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-SSC-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-SPO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SSC-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DRE-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-9932298:r:Degradation of CRY and PER proteins", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-202424:r:Downstream TCR signaling", "R-SSC-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9824272:r:Somitogenesis", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SCE-1236974:r:ER-Phagosome pathway", "R-DDI-5689880:r:Ub-specific processing proteases", "R-SSC-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY 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"R-MMU-193648", "R-DRE-5693616", "R-HSA-9013026", "R-HSA-9699150", "R-MMU-174430", "R-HSA-5685942", "R-HSA-9772755", "R-MMU-8980692", "R-DDI-6791226", "R-BTA-174437", "R-DRE-5685939", "R-RNO-110381", "R-DRE-3108214", "R-RNO-5685938", "R-MMU-9772755", "R-MMU-532668", "R-GGA-351442", "R-SCE-3232118", "R-HSA-5693568", "R-MMU-5693607", "R-CEL-75955", "R-GGA-5656121", "R-HSA-5651801", "R-DME-5656169", "R-HSA-5693571", "R-DME-5696400", "R-MMU-2299718", "R-HSA-9818564"], "pathways": ["R-RNO-5696400:r:Dual Incision in GG-NER", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-SCE-69091:r:Polymerase switching", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174417:r:Telomere C-strand (Lagging 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Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5689603:r:UCH proteinases", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-5689901:r:Metalloprotease DUBs", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-193648:r:NRAGE signals death through JNK", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-69091:r:Polymerase switching", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-XTR-110331:r:Cleavage of the damaged purine", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-MMU-69091:r:Polymerase switching", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-8951664:r:Neddylation", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-XTR-171319:r:Telomere Extension By Telomerase", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage 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"R-GGA-110312:r:Translesion synthesis by REV1", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-BTA-110331:r:Cleavage of the damaged purine", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-DDI-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-110331:r:Cleavage of the damaged purine", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-912446:r:Meiotic recombination", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-BTA-9670095:r:Inhibition of DNA recombination at telomere", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-5693616:r:Presynaptic 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"R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-BTA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DDI-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-DRE-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-164843:r:2-LTR circle formation", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-171319:r:Telomere Extension By Telomerase", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-1221632:r:Meiotic synapsis", "R-BTA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DME-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5689603:r:UCH proteinases", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-69091:r:Polymerase switching", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-RNO-5689901:r:Metalloprotease DUBs", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-GGA-353503:r:Translesion synthesis by Pol kappa", "R-XTR-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DRE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-193648:r:NRAGE signals death through JNK", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9699150:r:Defective DNA double strand break response due to BARD1 loss of function", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DME-5696400:r:Dual Incision in GG-NER", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes"], "type": "Domain"}, "IPR001360": {"description": "Glycoside hydrolase family 1", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_1", "pathway_ids": ["R-HSA-189085", "R-HSA-1307965", "R-RNO-5654726", "R-MMU-6811558", "R-MMU-5654720", "R-HSA-5654687", "R-MMU-190374", "R-RNO-1257604", "R-HSA-5654228", "R-RNO-109704", "R-HSA-5654693", "R-HSA-190374", "R-RNO-6811558", "R-HSA-5659898", "R-RNO-5654687", "R-RNO-189085", "R-MMU-5654228", "R-HSA-5654719", "R-MMU-5654719", "R-MMU-5673001", "R-RNO-5673001", "R-RNO-5654693", "R-MMU-109704", "R-HSA-5654689", "R-HSA-5654712", "R-HSA-9840310", "R-HSA-109704", "R-HSA-5654726", "R-RNO-190374", "R-MMU-1257604", "R-HSA-2219530", "R-RNO-5654689", "R-HSA-5673001", "R-HSA-6811558", "R-MMU-5654726", "R-HSA-5654219", "R-RNO-5654688", "R-MMU-5654219", "R-HSA-5654720", "R-MMU-5654687", "R-MMU-1307965", "R-MMU-5654693", "R-MMU-5654733", "R-MMU-5654689", "R-MMU-5654688", "R-HSA-1257604", "R-HSA-5654733", "R-MMU-5654712", "R-RNO-5654219", "R-HSA-5654688"], "pathways": ["R-HSA-189085:r:Digestion of dietary carbohydrate", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-109704:r:PI3K Cascade", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5659898:r:Intestinal saccharidase deficiencies", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-109704:r:PI3K Cascade", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-109704:r:PI3K Cascade", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1"], "type": "Family"}, "IPR001361": {"description": "Gp90 envelope polyprotein of equine infectious anemia virus (EIAV)", "go_ids": ["GO:0019031", "GO:0005198"], "go_terms": ["GO:0019031:viral envelope:C", "GO:0005198:structural molecule activity:F"], "name": "Gp90_EIAV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001362": {"description": "Glycoside hydrolase, family 32", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_32", "pathway_ids": ["PWY-8314"], "pathways": ["PWY-8314:t:inulin degradation"], "type": "Family"}, "IPR001364": {"description": "Haemagglutinin, influenzavirus A/B", "go_ids": ["GO:0019031", "GO:0019064", "GO:0046789"], "go_terms": ["GO:0019031:viral envelope:C", "GO:0019064:fusion of virus membrane with host plasma membrane:P", "GO:0046789:host cell surface receptor binding:F"], "name": "Hemagglutn_influenz_A/B", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168288", "R-HSA-168275", "R-HSA-168316", "R-HSA-198933", "R-HSA-168298", "R-HSA-168874", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-168298:r:Release", "R-HSA-168874:r:Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Family"}, "IPR001365": {"description": "Adenosine deaminase domain", "go_ids": ["GO:0019239"], "go_terms": ["GO:0019239:deaminase activity:F"], "name": "A_deaminase_dom", "pathway_ids": ["PWY-6611", "PWY-7179", "PWY-6609", "R-DRE-5683826", "R-DDI-6798695", "R-DDI-5683826", "R-HSA-6798695", "R-DDI-9755088", "R-DRE-74217", "R-MMU-2161541", "R-RNO-9755088", "R-RNO-74217", "R-DME-2161541", "R-DRE-2161541", "R-HSA-2161541", "R-PFA-9755088", "R-XTR-9755088", "R-XTR-74217", "R-CEL-74217", "R-MMU-9755088", "R-CEL-2161541", "R-DME-74217", "R-HSA-9734735", "R-DDI-74217", "R-DRE-6798695", "R-HSA-5683826", "R-MMU-74217", "R-DRE-9755088", "R-HSA-74217", "R-PFA-74217", "R-HSA-9755088"], "pathways": ["PWY-6611:t:adenine and adenosine salvage V", "PWY-7179:t:purine deoxyribonucleosides degradation I", "PWY-6609:t:adenine and adenosine salvage III", "R-DRE-5683826:r:Surfactant metabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-5683826:r:Surfactant metabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-9755088:r:Ribavirin ADME", "R-DRE-74217:r:Purine salvage", "R-MMU-2161541:r:Abacavir metabolism", "R-RNO-9755088:r:Ribavirin ADME", "R-RNO-74217:r:Purine salvage", "R-DME-2161541:r:Abacavir metabolism", "R-DRE-2161541:r:Abacavir metabolism", "R-HSA-2161541:r:Abacavir metabolism", "R-PFA-9755088:r:Ribavirin ADME", "R-XTR-9755088:r:Ribavirin ADME", "R-XTR-74217:r:Purine salvage", "R-CEL-74217:r:Purine salvage", "R-MMU-9755088:r:Ribavirin ADME", "R-CEL-2161541:r:Abacavir metabolism", "R-DME-74217:r:Purine salvage", "R-HSA-9734735:r:Defective ADA disrupts (deoxy)adenosine deamination", "R-DDI-74217:r:Purine salvage", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-5683826:r:Surfactant metabolism", "R-MMU-74217:r:Purine salvage", "R-DRE-9755088:r:Ribavirin ADME", "R-HSA-74217:r:Purine salvage", "R-PFA-74217:r:Purine salvage", "R-HSA-9755088:r:Ribavirin ADME"], "type": "Domain"}, "IPR001367": {"description": "Iron dependent repressor, metal binding and dimerisation domain", "go_ids": ["GO:0046914", "GO:0046983"], "go_terms": ["GO:0046914:transition metal ion binding:F", "GO:0046983:protein dimerization activity:F"], "name": "Fe_dep_repressor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001368": {"description": "TNFR/NGFR cysteine-rich region", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "TNFR/NGFR_Cys_rich_reg", "pathway_ids": ["R-HSA-1989781", "R-HSA-6798695", "R-HSA-8874081", "R-HSA-5218900", "R-HSA-5626978", "R-RNO-5668541", "R-HSA-3000178", "R-HSA-5669034", "R-BTA-5668541", "R-RNO-5357905", "R-HSA-75893", "R-RNO-193692", "R-SSC-69416", "R-RNO-5626978", "R-MMU-5668541", "R-MMU-202733", "R-RNO-205043", "R-MMU-3371378", "R-MMU-193634", "R-HSA-6783783", "R-MMU-75893", "R-HSA-9610379", "R-HSA-1474228", "R-BTA-198933", "R-HSA-193670", "R-HSA-209560", "R-MMU-209543", "R-HSA-205043", "R-RNO-209560", "R-HSA-3000171", "R-RNO-205025", "R-HSA-9927353", "R-HSA-6785807", "R-RNO-193634", "R-RNO-209563", "R-HSA-75158", "R-HSA-5357786", "R-HSA-69416", "R-RNO-209543", "R-HSA-209563", "R-SSC-5676594", "R-MMU-69416", "R-MMU-198933", "R-MMU-5357905", "R-MMU-6798695", "R-HSA-198933", "R-MMU-5669034", "R-HSA-193692", "R-HSA-3371378", "R-MMU-75158", "R-RNO-6798695", "R-MMU-205017", "R-HSA-205017", "R-MMU-5676594", "R-HSA-3000157", "R-HSA-209543", "R-HSA-5676594", "R-RNO-75157", "R-BTA-5676594", "R-MMU-75157", "R-MMU-5357956", "R-MMU-205025", "R-MMU-193692", "R-HSA-9638630", "R-HSA-5357905", "R-HSA-8877330", "R-RNO-75893", "R-MMU-5218900", "R-RNO-205017", "R-RNO-3371378", "R-MMU-5626978", "R-HSA-6803211", "R-MMU-205043", "R-HSA-9925563", "R-HSA-193648", "R-MMU-5357786", "R-SSC-5668541", "R-BTA-5669034", "R-MMU-209560", "R-MMU-9927353", "R-HSA-9913351", "R-SSC-3371378", "R-MMU-209563", "R-HSA-5213460", "R-RNO-69416", "R-HSA-193681", "R-HSA-5668541", "R-HSA-193634", "R-RNO-5218900", "R-HSA-5357956", "R-HSA-75157", "R-HSA-205025", "R-RNO-5357956", "R-HSA-140534", "R-SSC-75157", "R-RNO-5357786", "R-SSC-198933", "R-RNO-5669034", "R-HSA-202733", "R-SSC-5218900"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-75893:r:TNF signaling", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-SSC-69416:r:Dimerization of procaspase-8", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-MMU-3371378:r:Regulation by c-FLIP", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-6783783:r:Interleukin-10 signaling", "R-MMU-75893:r:TNF signaling", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-193670:r:p75NTR negatively regulates cell cycle via SC1", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-209563:r:Axonal growth stimulation", "R-HSA-75158:r:TRAIL signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-69416:r:Dimerization of procaspase-8", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-209563:r:Axonal growth stimulation", "R-SSC-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-69416:r:Dimerization of procaspase-8", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-3371378:r:Regulation by c-FLIP", "R-MMU-75158:r:TRAIL signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-205017:r:NFG and proNGF binds to p75NTR", "R-HSA-205017:r:NFG and proNGF binds to p75NTR", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-3000157:r:Laminin interactions", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-RNO-75157:r:FasL/ CD95L signaling", "R-BTA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-75157:r:FasL/ CD95L signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-205025:r:NADE modulates death signalling", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-75893:r:TNF signaling", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-RNO-205017:r:NFG and proNGF binds to p75NTR", "R-RNO-3371378:r:Regulation by c-FLIP", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5669034:r:TNFs bind their physiological receptors", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-SSC-3371378:r:Regulation by c-FLIP", "R-MMU-209563:r:Axonal growth stimulation", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-69416:r:Dimerization of procaspase-8", "R-HSA-193681:r:Ceramide signalling", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-5218900:r:CASP8 activity is inhibited", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-75157:r:FasL/ CD95L signaling", "R-HSA-205025:r:NADE modulates death signalling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-SSC-75157:r:FasL/ CD95L signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-SSC-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-5669034:r:TNFs bind their physiological receptors", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-SSC-5218900:r:CASP8 activity is inhibited"], "type": "Domain"}, "IPR001370": {"description": "BIR repeat", "go_ids": [], "go_terms": [], "name": "BIR_rpt", "pathway_ids": ["R-XTR-4615885", "R-RNO-8948751", "R-SSC-5663220", "R-HSA-168638", "R-HSA-9700645", "R-SSC-5357786", "R-HSA-8951664", "R-HSA-5689880", "R-RNO-5357905", "R-SSC-5357905", "R-MMU-8948751", "R-DME-8948751", "R-MMU-111459", "R-CFA-5676594", "R-XTR-141444", "R-MMU-5689880", "R-DME-390150", "R-DME-111465", "R-HSA-168927", "R-CFA-937041", "R-MMU-5668541", "R-BTA-2500257", "R-DME-8948747", "R-HSA-937041", "R-SPO-111469", "R-HSA-9824594", "R-SSC-4615885", "R-HSA-111463", "R-BTA-141444", "R-HSA-111459", "R-SSC-5675482", "R-HSA-5675482", "R-CFA-5357786", "R-HSA-141444", "R-MMU-8948747", "R-HSA-9648025", "R-HSA-6785807", "R-RNO-5663220", "R-HSA-5357786", "R-SSC-5676594", "R-DME-3769402", "R-RNO-8951664", "R-MMU-5357905", "R-RNO-9627069", "R-DME-209447", "R-HSA-8948751", "R-RNO-2467813", "R-RNO-111463", "R-BTA-9648025", "R-RNO-141444", "R-RNO-4615885", "R-BTA-8951664", "R-HSA-111469", "R-MMU-5676594", "R-HSA-2467813", "R-CFA-5668541", "R-HSA-3769402", "R-RNO-2500257", "R-HSA-5676594", "R-XTR-2467813", "R-SSC-68877", "R-CFA-5675482", "R-HSA-6803205", "R-BTA-5663220", "R-DME-111469", "R-MMU-5357956", "R-SSC-8951664", "R-CFA-5689880", "R-BTA-2467813", "R-HSA-5357905", "R-MMU-9627069", "R-HSA-9725370", "R-HSA-68877", "R-MMU-111464", "R-CFA-168638", "R-SSC-5689880", "R-DME-111459", "R-MMU-168638", "R-HSA-9627069", "R-HSA-4615885", "R-CFA-5357956", "R-MMU-111465", "R-SSC-141444", "R-SSC-9648025", "R-RNO-111464", "R-RNO-8948747", "R-MMU-3769402", "R-SSC-5668541", "R-MMU-5357786", "R-XTR-9648025", "R-HSA-2500257", "R-MMU-111463", "R-HSA-8948747", "R-DME-9627069", "R-RNO-68877", "R-BTA-4615885", "R-MMU-5675482", "R-DME-5675482", 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"R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-CFA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-SSC-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-8951664:r:Neddylation", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-111463:r:SMAC (DIABLO) binds to IAPs", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-BTA-8951664:r:Neddylation", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-SSC-68877:r:Mitotic Prometaphase", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DME-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-8951664:r:Neddylation", "R-CFA-5689880:r:Ub-specific processing proteases", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-SSC-5689880:r:Ub-specific processing proteases", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-RNO-8948747:r:Regulation of PTEN localization", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-8948747:r:Regulation of PTEN localization", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-RNO-68877:r:Mitotic Prometaphase", "R-BTA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-XTR-68877:r:Mitotic Prometaphase", "R-XTR-8951664:r:Neddylation", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion"], "type": "Repeat"}, "IPR001372": {"description": "Dynein light chain, type 1/2", "go_ids": ["GO:0030286", "GO:0007017"], "go_terms": ["GO:0030286:dynein complex:C", "GO:0007017:microtubule-based process:P"], "name": "Dynein_light_chain_typ-1/2", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-BTA-139910", "R-DME-3371497", "R-MMU-2467813", "R-MMU-1632852", "R-CEL-6798695", "R-HSA-380284", "R-BTA-6798695", "R-DDI-9646399", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-BTA-380259", "R-RNO-380320", "R-HSA-380320", "R-RNO-1632852", "R-BTA-2565942", "R-BTA-5620912", "R-RNO-380284", "R-BTA-2500257", "R-MMU-139910", "R-MMU-5620912", "R-DME-6807878", "R-HSA-139910", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-HSA-141444", "R-MMU-380270", "R-CEL-6807878", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-BTA-177504", "R-BTA-1632852", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-BTA-6811436", "R-HSA-1632852", "R-MMU-8854518", "R-BTA-3371497", "R-MMU-6798695", "R-RNO-2467813", "R-BTA-9646399", "R-DME-1632852", "R-RNO-5620924", "R-BTA-9648025", "R-BTA-5620924", "R-RNO-380270", "R-RNO-6798695", "R-MMU-3371497", "R-MMU-5663220", "R-RNO-141444", "R-SPO-1632852", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-CEL-1632852", "R-SCE-6798695", "R-MMU-111446", "R-RNO-3371497", "R-HSA-3371497", "R-BTA-5663220", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-BTA-6807878", "R-BTA-2467813", "R-RNO-2565942", "R-HSA-68877", "R-MMU-2132295", "R-HSA-111446", "R-BTA-380320", "R-HSA-5620912", "R-MMU-9648025", "R-BTA-380284", "R-BTA-2132295", "R-HSA-6811436", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-BTA-111446", "R-RNO-6807878", "R-RNO-8854518", "R-DME-6798695", "R-RNO-139910", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-HSA-177504", "R-BTA-380270", "R-BTA-8854518", "R-DDI-6807878", "R-MMU-177504", "R-RNO-9646399", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-111446", "R-HSA-380259", "R-BTA-141444"], "pathways": 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"R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-139910:r:Activation of BMF and translocation to mitochondria", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-139910:r:Activation of BMF and translocation to mitochondria", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380270:r:Recruitment of mitotic centrosome 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"R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated 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"R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation 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"IPR001399": {"description": "VP6 blue-tongue virus inner capsid protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Orbi_VP6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001400": {"description": "Somatotropin/prolactin", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Somatotropin/Prolactin", "pathway_ids": ["R-RNO-1170546", "R-BTA-982772", "R-MMU-1170546", "R-HSA-1170546", "R-BTA-1170546", "R-HSA-977225", "R-GGA-422085", "R-SSC-422085", "R-MMU-982772", "R-RNO-982772", "R-CFA-982772", "R-CFA-422085", "R-GGA-1170546", "R-HSA-422085", "R-HSA-982772", "R-MMU-422085", "R-SSC-982772", "R-RNO-422085", "R-CFA-1170546", "R-SSC-1170546", "R-GGA-982772", "R-HSA-9927426"], "pathways": ["R-RNO-1170546:r:Prolactin receptor signaling", "R-BTA-982772:r:Growth hormone receptor signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-BTA-1170546:r:Prolactin receptor signaling", "R-HSA-977225:r:Amyloid fiber formation", "R-GGA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-SSC-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-CFA-982772:r:Growth hormone receptor signaling", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-GGA-1170546:r:Prolactin receptor signaling", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-SSC-982772:r:Growth hormone receptor signaling", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-CFA-1170546:r:Prolactin receptor signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-GGA-982772:r:Growth hormone receptor signaling", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Family"}, "IPR001401": {"description": "Dynamin, GTPase domain", "go_ids": ["GO:0005525", "GO:0003924"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0003924:GTPase activity:F"], "name": "Dynamin_GTPase", "pathway_ids": ["R-MMU-8856828", "R-DDI-169911", "R-DME-190873", "R-BTA-196025", "R-HSA-8856828", "R-HSA-166016", "R-CEL-432722", "R-HSA-9766229", "R-BTA-190873", "R-BTA-75153", "R-RNO-196025", "R-SSC-1169408", "R-DME-3928665", "R-HSA-203641", "R-RNO-432722", "R-SPO-169911", "R-MMU-196025", "R-DME-437239", "R-RNO-432720", "R-MMU-166016", "R-HSA-432720", "R-DME-196025", "R-HSA-437239", "R-BTA-166016", "R-CFA-1169408", "R-HSA-909733", "R-SPO-190873", "R-SCE-196025", "R-HSA-9031628", "R-BTA-1169408", "R-SPO-196025", "R-MMU-9766229", "R-DRE-169911", "R-HSA-2132295", "R-SCE-169911", "R-DME-432720", "R-HSA-190873", "R-CEL-432720", "R-RNO-1169408", "R-MMU-432722", "R-CEL-190873", "R-CEL-437239", "R-RNO-169911", "R-MMU-203641", "R-HSA-1169408", "R-MMU-169911", "R-RNO-75153", "R-MMU-190873", "R-RNO-190873", "R-MMU-2132295", "R-HSA-169911", "R-DME-8856828", "R-BTA-437239", "R-RNO-8856828", "R-HSA-9837999", "R-RNO-203641", "R-MMU-432720", "R-HSA-75153", "R-HSA-432722", "R-BTA-2132295", "R-DRE-75153", "R-HSA-196025", "R-BTA-8856828", "R-SCE-75153", "R-CEL-8856828", "R-RNO-2132295", "R-MMU-437239", "R-RNO-437239", "R-CEL-196025", "R-DME-432722", "R-DDI-75153", "R-MMU-1169408", "R-MMU-75153", "R-CEL-3928665", "R-HSA-177504", "R-CEL-75153", "R-CEL-1169408", "R-HSA-3928665", "R-RNO-9766229", "R-RNO-166016", "R-SPO-75153", "R-PFA-75153", "R-SCE-190873"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DDI-169911:r:Regulation of Apoptosis", "R-DME-190873:r:Gap junction degradation", "R-BTA-196025:r:Formation of annular gap junctions", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-190873:r:Gap junction degradation", "R-BTA-75153:r:Apoptotic execution phase", "R-RNO-196025:r:Formation of annular gap junctions", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-169911:r:Regulation of Apoptosis", "R-MMU-196025:r:Formation of annular gap junctions", "R-DME-437239:r:Recycling pathway of L1", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-196025:r:Formation of annular gap junctions", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CFA-1169408:r:ISG15 antiviral mechanism", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SPO-190873:r:Gap junction degradation", "R-SCE-196025:r:Formation of annular gap junctions", "R-HSA-9031628:r:NGF-stimulated transcription", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-SPO-196025:r:Formation of annular gap junctions", "R-MMU-9766229:r:Degradation of CDH1", "R-DRE-169911:r:Regulation of Apoptosis", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SCE-169911:r:Regulation of Apoptosis", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-190873:r:Gap junction degradation", "R-CEL-437239:r:Recycling pathway of L1", "R-RNO-169911:r:Regulation of Apoptosis", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-169911:r:Regulation of Apoptosis", "R-RNO-75153:r:Apoptotic execution phase", "R-MMU-190873:r:Gap junction degradation", "R-RNO-190873:r:Gap junction degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-169911:r:Regulation of Apoptosis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-75153:r:Apoptotic execution phase", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-DRE-75153:r:Apoptotic execution phase", "R-HSA-196025:r:Formation of annular gap junctions", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-SCE-75153:r:Apoptotic execution phase", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-CEL-196025:r:Formation of annular gap junctions", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-75153:r:Apoptotic execution phase", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-75153:r:Apoptotic execution phase", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-CEL-75153:r:Apoptotic execution phase", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9766229:r:Degradation of CDH1", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-SPO-75153:r:Apoptotic execution phase", "R-PFA-75153:r:Apoptotic execution phase", "R-SCE-190873:r:Gap junction degradation"], "type": "Domain"}, "IPR001403": {"description": "Coat protein VP1/VP2, Parvovirus", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Parvovirus_coat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001404": {"description": "Heat shock protein Hsp90 family", "go_ids": ["GO:0005524", "GO:0006457", "GO:0140662", "GO:0016887"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006457:protein folding:P", "GO:0140662:ATP-dependent protein folding chaperone:F", "GO:0016887:ATP hydrolysis activity:F"], "name": "Hsp90_fam", "pathway_ids": ["R-MMU-5218920", "R-BTA-71403", "R-HSA-8852276", "R-HSA-1227986", "R-HSA-9665233", "R-HSA-9679191", "R-DME-3371511", "R-MMU-844456", "R-SSC-8852276", "R-MMU-2029482", "R-SSC-168928", "R-DME-9013418", "R-DDI-3371571", "R-SPO-203615", "R-HSA-1679131", "R-SPO-3371497", "R-SPO-3371511", "R-BTA-8937144", "R-BTA-380270", "R-BTA-8854518", "R-CFA-1679131", "R-SSC-380320", "R-HSA-8957275", "R-RNO-5675482", "R-RNO-168928", "R-SCE-3371511", "R-HSA-380259", "R-RNO-8939211", "R-CEL-5218920", "R-BTA-1679131", "R-HSA-9646399", "R-RNO-6785807", "R-HSA-9013418", "R-SSC-3371497", "R-HSA-9665251", "R-BTA-1227986", "R-DME-9652282", "R-RNO-9009391", "R-DRE-3371497", "R-MMU-9009391", "R-RNO-9018519", "R-RNO-5218920", "R-MMU-380320", "R-HSA-203615", "R-HSA-9834752", "R-RNO-8863795", "R-RNO-399954", "R-BTA-9018519", "R-BTA-8957275", "R-SSC-8939211", "R-HSA-5218920", "R-HSA-8863795", "R-CEL-8939211", "R-BTA-4420097", "R-BTA-2565942", "R-MMU-3371511", "R-DME-399954", "R-HSA-192905", "R-MMU-9652282", "R-RNO-380284", "R-DDI-5218920", "R-SSC-2565942", "R-RNO-3371571", "R-SSC-9652282", "R-MMU-5620912", "R-SSC-3371568", "R-HSA-71403", "R-MMU-1679131", "R-DDI-6798695", "R-BTA-203615", "R-SSC-8854518", "R-HSA-381183", "R-SPO-844456", "R-MMU-380259", "R-SSC-5675482", "R-HSA-9660826", "R-MMU-380270", "R-RNO-3371511", "R-DDI-3371511", "R-SCE-1474151", "R-DDI-844456", "R-SSC-9018519", "R-BTA-1474151", "R-HSA-5637810", "R-RNO-203615", "R-DME-5218920", "R-DME-3371568", "R-MMU-3371568", "R-CFA-3000480", "R-HSA-399954", "R-DRE-3371571", "R-MMU-9013418", "R-MMU-6785807", "R-RNO-380270", "R-MMU-3371497", "R-RNO-6798695", "R-SSC-1227986", "R-SCE-3371497", "R-BTA-2029482", "R-SSC-6798695", "R-CEL-1227986", "R-HSA-9705671", "R-HSA-1474151", "R-HSA-168928", "R-HSA-3000480", "R-MMU-8852276", "R-DDI-9009391", "R-BTA-3371511", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-9665737", "R-CEL-3371511", "R-HSA-9665348", "R-HSA-3371497", "R-MMU-8937144", "R-CEL-3371571", "R-MMU-380284", "R-HSA-5336415", "R-RNO-2565942", "R-BTA-380320", "R-DDI-71403", "R-DME-8863795", "R-CEL-1474151", "R-DME-8937144", "R-RNO-71403", "R-HSA-3371568", "R-SSC-8863795", "R-RNO-9013418", "R-DDI-2029482", "R-HSA-9665249", "R-DDI-1474151", "R-DME-6798695", "R-MMU-1227986", "R-MMU-5675482", "R-SCE-9009391", "R-SSC-4420097", "R-RNO-1227986", "R-MMU-3371571", "R-BTA-5218920", "R-HSA-9665250", "R-HSA-380270", "R-BTA-9009391", "R-DRE-844456", "R-DME-203615", "R-MMU-1474151", "R-RNO-380259", "R-BTA-844456", "R-SCE-8939211", "R-CFA-6785807", "R-HSA-9009391", "R-HSA-611105", "R-CEL-5675482", "R-DDI-3371497", "R-HSA-9634285", "R-HSA-3371571", "R-CEL-9009391", "R-DME-8939211", "R-SCE-844456", "R-RNO-3000480", "R-SSC-5620912", "R-SCE-5218920", "R-HSA-6798695", "R-DRE-3371568", "R-HSA-3000484", "R-DRE-399954", "R-BTA-8939211", "R-SSC-3371511", "R-HSA-9920588", "R-BTA-3371568", "R-DME-3371497", "R-SPO-3371571", "R-CEL-9652282", "R-CEL-6798695", "R-SSC-9013418", "R-HSA-380284", "R-SSC-399954", "R-BTA-6798695", "R-MMU-4420097", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-8957275", "R-RNO-380320", "R-BTA-380259", "R-HSA-4420097", "R-HSA-380320", "R-DME-2029482", "R-RNO-1679131", "R-SPO-9009391", "R-DME-3371571", "R-DRE-6798695", "R-HSA-8939211", "R-MMU-381426", "R-CEL-8957275", "R-MMU-399954", "R-RNO-1474151", "R-CEL-381426", "R-BTA-5675482", "R-BTA-5620912", "R-BTA-9013418", "R-MMU-71403", "R-SSC-3371571", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-9652282", "R-HSA-9018519", "R-HSA-381426", "R-DRE-9018519", "R-HSA-5601884", "R-CEL-203615", "R-BTA-8863795", "R-RNO-8937144", "R-DME-1227986", "R-HSA-9665244", "R-HSA-9665686", "R-SSC-380259", "R-MMU-8939211", "R-DDI-6785807", "R-DME-9018519", "R-HSA-5675482", "R-CEL-6785807", "R-BTA-3371571", "R-SPO-5218920", "R-HSA-2029482", "R-HSA-6785807", "R-RNO-844456", "R-MMU-9018519", "R-DDI-203615", "R-SSC-380284", "R-RNO-381426", "R-SPO-9652282", "R-DDI-399954", "R-BTA-168928", "R-SCE-203615", "R-HSA-9613829", "R-MMU-8854518", "R-DME-1474151", "R-MMU-6798695", "R-RNO-9652282", "R-DDI-8939211", "R-CEL-8937144", "R-BTA-3371497", "R-RNO-4420097", "R-HSA-844456", "R-MMU-8863795", "R-HSA-3371511", "R-SPO-6798695", "R-SSC-380270", "R-CEL-8863795", "R-SPO-1474151", "R-DRE-2029482", "R-BTA-9652282", "R-MMU-203615", "R-MMU-3000480", "R-RNO-5620912", "R-HSA-9665245", "R-RNO-2029482", "R-HSA-2565942", "R-RNO-3371568", "R-BTA-399954", "R-BTA-6785807", "R-RNO-8957275", "R-HSA-1236382", "R-BTA-381426", "R-CFA-8957275", "R-DME-9009391", "R-SSC-2029482", "R-RNO-8852276", "R-HSA-5620912", "R-DRE-8939211", "R-SCE-3371571", "R-BTA-380284", "R-HSA-8937144", "R-CFA-381426", "R-HSA-9820962", "R-DRE-3371511", "R-MMU-168928", "R-RNO-8854518", "R-HSA-9665246"], "pathways": ["R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-3371511:r:HSF1 activation", "R-MMU-844456:r:The NLRP3 inflammasome", "R-SSC-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SSC-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-SPO-203615:r:eNOS activation", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-3371511:r:HSF1 activation", "R-BTA-8937144:r:Aryl hydrocarbon receptor signalling", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-CFA-1679131:r:Trafficking and processing of endosomal TLR", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-RNO-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SCE-3371511:r:HSF1 activation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8939211:r:ESR-mediated signaling", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-9646399:r:Aggrephagy", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", 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cells", "R-CFA-6798695:r:Neutrophil degranulation", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-9033241:r:Peroxisomal protein import", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Domain"}, "IPR001434": {"description": "Large cysteine-rich periplasmic protein OmcB-like, DUF11 domain", "go_ids": [], "go_terms": [], "name": "OmcB-like_DUF11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001436": {"description": "Alpha crystallin/Small heat shock protein, animal type", "go_ids": [], "go_terms": [], "name": "Alpha-crystallin/sHSP_animal", "pathway_ids": ["R-MMU-450408", "R-BTA-450408", "R-BTA-5687128", "R-BTA-3371571", "R-CEL-3371571", "R-MMU-9009391", "R-RNO-9009391", "R-MMU-4420097", "R-MMU-3371571", "R-RNO-5687128", "R-BTA-9009391", "R-HSA-4420097", "R-HSA-9009391", "R-BTA-4420097", "R-HSA-5687128", "R-DME-3371571", "R-HSA-3371571", "R-RNO-3371571", "R-HSA-450408", "R-MMU-5687128", "R-SSC-3371571", "R-RNO-450408", 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"R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-SSC-3371571:r:HSF1-dependent transactivation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-3371571:r:HSF1-dependent transactivation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Family"}, "IPR001437": {"description": "Transcription elongation factor, GreA/GreB, C-terminal", "go_ids": ["GO:0003677", "GO:0032784"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0032784:regulation of DNA-templated transcription elongation:P"], "name": "Tscrpt_elong_fac_GreA/B_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001439": {"description": "Hyaluronidase PH20/Hyaluronidase-5", "go_ids": ["GO:0004415", "GO:0007342"], "go_terms": ["GO:0004415:hyalurononglucosaminidase activity:F", "GO:0007342:fusion of sperm to egg plasma membrane involved in single fertilization:P"], "name": "Hyaluronidase_PH20/Hyal5", "pathway_ids": ["PWY-6573", "R-HSA-2160916", "R-MMU-2160916", "R-MMU-2534343", "R-HSA-2534343"], "pathways": ["PWY-6573:t:chondroitin sulfate degradation (metazoa)", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida"], "type": "Family"}, "IPR001441": {"description": "Decaprenyl diphosphate synthase-like", "go_ids": ["GO:0016765"], "go_terms": ["GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "UPP_synth-like", "pathway_ids": ["R-DRE-446199", "R-HSA-4755609", "R-MMU-446199", "R-SPO-446199", "R-HSA-446199", "R-SCE-446199"], "pathways": ["R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-4755609:r:Defective DHDDS causes RP59", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-446199:r:Synthesis of dolichyl-phosphate"], "type": "Family"}, "IPR001442": {"description": "Collagen IV, non-collagenous", "go_ids": ["GO:0005201", "GO:0005581"], "go_terms": ["GO:0005201:extracellular matrix structural constituent:F", "GO:0005581:collagen trimer:C"], "name": "Collagen_IV_NC", "pathway_ids": ["R-HSA-186797", "R-CEL-1592389", "R-BTA-2243919", "R-CEL-2022090", "R-HSA-2243919", "R-BTA-216083", "R-DME-419037", "R-CEL-1650814", "R-HSA-3000480", "R-HSA-3000178", "R-HSA-3000157", "R-HSA-9010553", "R-BTA-1442490", "R-CEL-1566977", "R-MMU-419037", "R-BTA-2022090", "R-MMU-2243919", "R-HSA-1650814", "R-HSA-9638630", "R-MMU-3000171", "R-CEL-2243919", "R-BTA-3000171", "R-HSA-8948216", "R-BTA-186797", "R-CEL-204005", "R-CEL-3000157", "R-HSA-1442490", "R-BTA-1650814", "R-CEL-216083", "R-HSA-2214320", "R-MMU-3000157", "R-CEL-5694530", "R-HSA-216083", "R-MMU-1566977", "R-DME-1650814", "R-CEL-2214320", "R-BTA-1566977", "R-HSA-1566977", "R-HSA-3000171", "R-CEL-186797", "R-DME-446107", "R-DME-8948216", "R-CEL-8948216", "R-HSA-419037", "R-MMU-2022090", "R-DME-216083", "R-HSA-2022090", "R-MMU-1650814", "R-MMU-216083", "R-CEL-1442490", "R-MMU-186797", "R-MMU-1442490", "R-CEL-3000171", "R-CEL-419037", "R-DME-186797"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-BTA-2243919:r:Crosslinking of collagen fibrils", "R-CEL-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-BTA-216083:r:Integrin cell surface interactions", "R-DME-419037:r:NCAM1 interactions", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3000157:r:Laminin interactions", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-1442490:r:Collagen degradation", "R-CEL-1566977:r:Fibronectin matrix formation", "R-MMU-419037:r:NCAM1 interactions", "R-BTA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-BTA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-8948216:r:Collagen chain trimerization", "R-BTA-186797:r:Signaling by PDGF", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-CEL-3000157:r:Laminin interactions", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-2214320:r:Anchoring fibril formation", "R-MMU-3000157:r:Laminin interactions", "R-CEL-5694530:r:Cargo concentration in the ER", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-CEL-2214320:r:Anchoring fibril formation", "R-BTA-1566977:r:Fibronectin matrix formation", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-186797:r:Signaling by PDGF", "R-DME-446107:r:Type I hemidesmosome assembly", "R-DME-8948216:r:Collagen chain trimerization", "R-CEL-8948216:r:Collagen chain trimerization", "R-HSA-419037:r:NCAM1 interactions", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-216083:r:Integrin cell surface interactions", "R-CEL-1442490:r:Collagen degradation", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-1442490:r:Collagen degradation", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-419037:r:NCAM1 interactions", "R-DME-186797:r:Signaling by PDGF"], "type": "Domain"}, "IPR001443": {"description": "Staphylocoagulase repeat", "go_ids": [], "go_terms": [], "name": "Staphylcoagulase_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR001444": {"description": "Flagellar basal body rod protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Flag_bb_rod_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001447": {"description": "Arylamine N-acetyltransferase", "go_ids": ["GO:0016407"], "go_terms": ["GO:0016407:acetyltransferase activity:F"], "name": "Arylamine_N-AcTrfase", "pathway_ids": ["R-MMU-9753281", "R-RNO-9753281", "R-GGA-9753281", "R-HSA-156582", "R-GGA-156582", "R-MMU-156582", "R-HSA-9753281", "R-BTA-156582", "R-BTA-9753281", "R-RNO-156582"], "pathways": ["R-MMU-9753281:r:Paracetamol ADME", "R-RNO-9753281:r:Paracetamol ADME", "R-GGA-9753281:r:Paracetamol ADME", "R-HSA-156582:r:Acetylation", "R-GGA-156582:r:Acetylation", "R-MMU-156582:r:Acetylation", "R-HSA-9753281:r:Paracetamol ADME", "R-BTA-156582:r:Acetylation", "R-BTA-9753281:r:Paracetamol ADME", "R-RNO-156582:r:Acetylation"], "type": "Family"}, "IPR001448": {"description": "Small acid-soluble spore protein, alpha/beta-type", "go_ids": ["GO:0003690", "GO:0006265"], "go_terms": ["GO:0003690:double-stranded DNA binding:F", "GO:0006265:DNA topological change:P"], "name": "SASP_alpha/beta-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001451": {"description": "Hexapeptide repeat", "go_ids": [], "go_terms": [], "name": "Hexapep", "pathway_ids": ["R-BTA-3371497", "R-BTA-6807878", "R-BTA-6811436", "R-BTA-2132295", "R-MTU-936721"], "pathways": ["R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-2132295:r:MHC class II antigen presentation", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Repeat"}, "IPR001452": {"description": "SH3 domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "SH3_domain", "pathway_ids": ["R-RNO-1236973", "R-HSA-9013405", "R-SSC-9766229", "R-MMU-180336", "R-MMU-5654720", "R-RNO-2028269", "R-BTA-1227986", "R-HSA-69231", "R-HSA-9027284", "R-RNO-512988", "R-RNO-2871809", "R-CEL-5654219", "R-MMU-5654221", "R-MMU-5689880", "R-MMU-201556", "R-RNO-177504", "R-RNO-6805567", "R-HSA-512988", "R-XTR-1433557", "R-CEL-182971", "R-RNO-416476", "R-DME-5663213", "R-XTR-5654726", "R-DME-9607240", "R-MMU-9013407", "R-MMU-170968", "R-RNO-9705462", "R-DRE-186763", "R-XTR-9013148", "R-CEL-456926", "R-HSA-389356", "R-HSA-399954", "R-DRE-8980692", "R-RNO-5621575", "R-DME-1963642", "R-RNO-9013420", "R-HSA-179812", "R-XTR-74749", "R-RNO-2871796", "R-BTA-1660499", "R-SSC-6798695", "R-MMU-187577", "R-CEL-1227986", "R-DME-432553", "R-HSA-6803205", "R-CEL-5654227", "R-HSA-8849468", "R-MMU-5693565", "R-MMU-196108", "R-XTR-5673001", "R-BTA-9927354", 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"R-RNO-114604", "R-DME-8849932", "R-MMU-2871809", "R-BTA-389513", "R-MMU-9013026", "R-RNO-5658442", "R-RNO-264870", "R-DME-8849471", "R-DME-5654726", "R-DRE-373753", "R-RNO-1250347", "R-HSA-6802952", "R-RNO-9013409", "R-MMU-6811558", "R-RNO-9020558", "R-RNO-372708", "R-HSA-912631", "R-HSA-420029", "R-XTR-112412", "R-MMU-8948751", "R-RNO-8866654", "R-DME-8948751", "R-BTA-5654710", "R-RNO-5218920", "R-RNO-912631", "R-MMU-202430", "R-DRE-3928664", "R-RNO-399954", "R-BTA-4420097", "R-DME-2453902", "R-SSC-8866376", "R-MMU-186763", "R-HSA-3299685", "R-RNO-5682910", "R-HSA-983695", "R-HSA-9927353", "R-CEL-5674135", "R-CEL-212676", "R-RNO-438066", "R-HSA-419037", "R-HSA-8866654", "R-RNO-456926", "R-HSA-211728", "R-HSA-9748787", "R-CEL-8851805", "R-CFA-399719", "R-HSA-389357", "R-MMU-170984", "R-BTA-8980692", "R-CEL-8948751", "R-CEL-6811558", "R-MMU-9766229", "R-MMU-354192", "R-HSA-8865999", "R-MMU-5654227", "R-XTR-180292", "R-BTA-430116", "R-HSA-191650", "R-CEL-5654720", "R-XTR-210993", "R-MMU-191650", "R-HSA-8849932", "R-RNO-5654727", "R-MMU-8964616", "R-DRE-983168", "R-RNO-167044", "R-RNO-416482", "R-RNO-389359", "R-MMU-2132295", "R-DME-69416", "R-RNO-3928662", "R-RNO-1251985", "R-CEL-8856828", "R-BTA-399956", "R-HSA-5655332", "R-DME-5654719", "R-HSA-2871809", "R-DME-8939236", "R-DME-512988", "R-MMU-2029481", "R-MMU-389513", "R-DME-9833482", "R-XTR-8980692", "R-DRE-9009391", "R-RNO-9032759", "R-DRE-9013420", "R-GGA-8980692", "R-RNO-983695", "R-DRE-4420097", "R-RNO-5654227", "R-BTA-3928665", "R-CEL-114604", "R-HSA-9702518", "R-DME-5689880", "R-HSA-391160", "R-MMU-1253288", "R-MMU-1433559", "R-DRE-5674135", "R-CEL-8980692", "R-HSA-8856828", "R-BTA-202424", "R-DRE-9639288", "R-MMU-5689901", "R-HSA-5654228", "R-DME-912631", "R-HSA-2029481", "R-RNO-8983432", "R-RNO-9027276", "R-CEL-5673001", "R-HSA-5694530", "R-BTA-5576892", "R-BTA-75892", "R-DME-210993", "R-BTA-9013409", "R-CEL-5654732", "R-DRE-6798695", "R-MMU-381426", "R-DME-264870", "R-MMU-399954", "R-CEL-5654228", "R-RNO-170968", "R-HSA-9673767", "R-RNO-8865999", "R-GGA-3928662", "R-RNO-9748787", "R-DME-5673000", "R-CEL-525793", "R-HSA-9927354", "R-XTR-9013409", "R-MMU-1433557", "R-HSA-451308", "R-CEL-9860927", "R-HSA-166058", "R-MMU-5621575", "R-RNO-432720", "R-DRE-8934903", "R-GGA-9013148", "R-XTR-1963642", "R-MMU-5620916", "R-MMU-373753", "R-MMU-9013406", "R-HSA-8941237", "R-RNO-9639288", "R-MMU-6798695", "R-CEL-186763", "R-BTA-354192", "R-RNO-6794361", "R-HSA-8940973", "R-RNO-9674555", "R-CEL-8863795", "R-HSA-6809371", "R-DRE-912631", "R-BTA-5654720", "R-RNO-1295596", "R-MMU-6807878", "R-RNO-1222556", "R-DME-2428933", "R-RNO-2029482", "R-RNO-5668599", "R-BTA-186763", "R-HSA-2871837", "R-HSA-210990", "R-GGA-186763", "R-CEL-5654706", "R-BTA-5674135", "R-HSA-1222556", "R-DME-9013406", "R-RNO-203641", "R-DME-1250347", "R-HSA-432722", "R-HSA-9617324", "R-BTA-6807004", "R-HSA-5685938", "R-XTR-8856828", "R-HSA-445355", "R-HSA-5654706", "R-BTA-399955", "R-RNO-5654221", "R-HSA-5654227", "R-DRE-9013148", "R-HSA-3928663", "R-RNO-74751", "R-HSA-438066", "R-CEL-4420097", "R-MMU-9927354", "R-MMU-8866376", "R-HSA-5627123", "R-BTA-5621480", "R-MMU-416482", "R-XTR-983168", "R-RNO-1855204", "R-CEL-8849471", "R-DRE-3928665", "R-CEL-8874081", "R-HSA-8957275", "R-RNO-975578", "R-DRE-1251985", "R-HSA-9664422", "R-CEL-5218920", "R-HSA-5689880", "R-MMU-9013408", "R-MMU-210990", "R-HSA-1489509", "R-MMU-210993", "R-HSA-9856532", "R-DME-5654732", "R-BTA-1963642", "R-HSA-9639288", "R-MMU-5663213", "R-MMU-456926", "R-MMU-9013420", "R-BTA-5663213", "R-HSA-8853659", "R-SPO-5668599", "R-DME-1295596", "R-DME-177504", "R-HSA-446107", "R-MMU-5673001", "R-MMU-167044", "R-HSA-9026527", "R-RNO-5673000", "R-HSA-181430", "R-HSA-182971", "R-RNO-5654732", "R-BTA-182971", "R-HSA-2424491", "R-HSA-8983432", "R-XTR-5654699", "R-HSA-5637810", "R-HSA-2022090", "R-RNO-9696264", "R-HSA-445144", "R-MMU-975578", "R-CEL-8856825", "R-MMU-9768727", "R-MMU-9860927", "R-RNO-8851907", "R-HSA-8857538", "R-HSA-5625900", "R-DME-432720", "R-MMU-430116", "R-MMU-8980692", "R-CEL-432720", "R-RNO-1169408", "R-BTA-375165", "R-HSA-2029485", "R-DME-1433557", "R-HSA-9013423", "R-HSA-8851907", "R-BTA-912526", "R-CEL-354192", "R-MMU-512988", "R-DME-416476", "R-SPO-9013420", "R-HSA-1250196", "R-HSA-9603798", "R-SSC-2029481", "R-MMU-3928664", "R-BTA-8856828", "R-MMU-437239", "R-RNO-446107", "R-DME-5357905", "R-MMU-212676", "R-MMU-391160", "R-MMU-9028731", "R-BTA-3928664", "R-RNO-1227986", "R-MMU-1660499", "R-MMU-8851680", "R-DRE-8874081", "R-HSA-912526", "R-HSA-8875656", "R-DME-5654706", "R-DRE-399954", "R-XTR-1257604", "R-BTA-9013424", "R-MMU-5607764", "R-DME-69231", "R-RNO-8866376", "R-CEL-2453902", "R-CEL-438066", "R-RNO-9927353", "R-MMU-446388", "R-SSC-6811558", "R-HSA-8849471", "R-BTA-3928663", "R-DME-2424491", "R-DME-111465", "R-BTA-2871809", "R-HSA-9649948", "R-BTA-391160", "R-SCE-9013420", "R-RNO-9013406", "R-HSA-202430", "R-HSA-5621480", "R-HSA-5655302", "R-CEL-9013148", "R-DME-438066", "R-HSA-381426", "R-RNO-389357", "R-MMU-9748787", "R-BTA-5576893", "R-RNO-5654693", "R-RNO-8853659", "R-MMU-166016", "R-MMU-8849932", "R-MMU-438066", "R-CEL-177929", "R-MMU-2453902", "R-MMU-5654700", "R-CEL-432142", "R-HSA-982772", "R-DRE-210990", "R-BTA-416476", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-5658442", "R-HSA-1253288", "R-RNO-9028731", "R-DRE-416482", "R-HSA-5654704", "R-SCE-392517", "R-DME-5625900", "R-CEL-375165", "R-HSA-5689901", "R-HSA-187577", "R-DME-8957275", "R-CEL-437239", "R-HSA-416476", "R-DME-6811558", "R-CEL-418885", "R-HSA-1236382", "R-HSA-9619229", "R-HSA-5620912", "R-HSA-5607764", "R-MMU-112308", "R-XTR-8875656", "R-HSA-9028731", "R-HSA-354192", "R-XTR-8851805", "R-HSA-193648", "R-RNO-1963640", "R-HSA-8964616", "R-MMU-6794361", "R-HSA-354194", "R-XTR-9013424", "R-MMU-181429", "R-GGA-432142", "R-DME-212676", "R-RNO-389356", "R-CEL-2029482", "R-HSA-1236394", "R-BTA-1433559", "R-BTA-2730905", "R-HSA-5687128", "R-DME-9841922", "R-BTA-422356", "R-RNO-5654720", "R-MMU-2424491", "R-DRE-1295596", "R-MMU-8849472", "R-DME-4420097"], "pathways": ["R-RNO-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SSC-9766229:r:Degradation of CDH1", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-RNO-2028269:r:Signaling by Hippo", "R-BTA-1227986:r:Signaling by ERBB2", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-201556:r:Signaling by ALK", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-RNO-6805567:r:Keratinization", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-XTR-1433557:r:Signaling by SCF-KIT", "R-CEL-182971:r:EGFR downregulation", "R-RNO-416476:r:G alpha (q) signalling events", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-XTR-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-9607240:r:FLT3 Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-186763:r:Downstream signal transduction", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-389356:r:Co-stimulation by CD28", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-XTR-74749:r:Signal attenuation", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-1227986:r:Signaling by ERBB2", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-XTR-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-5218900:r:CASP8 activity is inhibited", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-3928664:r:Ephrin signaling", "R-DME-74749:r:Signal attenuation", "R-XTR-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-9696264:r:RND3 GTPase cycle", "R-RNO-389948:r:Co-inhibition by PD-1", "R-DME-6794361:r:Neurexins and neuroligins", "R-BTA-210993:r:Tie2 Signaling", "R-DRE-193648:r:NRAGE signals death through JNK", "R-XTR-5654689:r:PI-3K cascade:FGFR1", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-8866376:r:Reelin signalling pathway", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-BTA-8853659:r:RET signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-XTR-182971:r:EGFR downregulation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-525793:r:Myogenesis", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-SPO-8941237:r:Invadopodia formation", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-6794361:r:Neurexins and neuroligins", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-BTA-201556:r:Signaling by ALK", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-8849473:r:PTK6 Expression", "R-DME-9013409:r:RHOJ GTPase cycle", "R-XTR-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-2028269:r:Signaling by Hippo", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SSC-2424491:r:DAP12 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1266695:r:Interleukin-7 signaling", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9833482:r:PKR-mediated signaling", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-167021:r:PLC-gamma1 signalling", "R-RNO-9607240:r:FLT3 Signaling", "R-XTR-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-DME-74751:r:Insulin receptor signalling cascade", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-DME-3928664:r:Ephrin signaling", "R-HSA-447038:r:NrCAM interactions", "R-DDI-9033241:r:Peroxisomal protein import", "R-GGA-9013420:r:RHOU GTPase cycle", "R-GGA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-XTR-9013408:r:RHOG GTPase cycle", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8875656:r:MET receptor recycling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8851805:r:MET activates RAS signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-RNO-9842663:r:Signaling by LTK", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-912631:r:Regulation of signaling by CBL", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DME-112412:r:SOS-mediated signalling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-BTA-9607240:r:FLT3 Signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-182971:r:EGFR downregulation", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-SPO-5689901:r:Metalloprotease DUBs", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-BTA-373753:r:Nephrin family interactions", "R-GGA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-114604:r:GPVI-mediated activation cascade", "R-HSA-432142:r:Platelet sensitization by LDL", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DRE-191650:r:Regulation of gap junction activity", "R-GGA-9013106:r:RHOC GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-XTR-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-GGA-8875656:r:MET receptor recycling", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-164944:r:Nef and signal transduction", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-DME-445095:r:Interaction between L1 and Ankyrins", "R-XTR-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-977443:r:GABA receptor activation", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-3928664:r:Ephrin signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-XTR-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-9013408:r:RHOG GTPase cycle", "R-SSC-1433559:r:Regulation of KIT signaling", "R-CEL-6807004:r:Negative regulation of MET activity", "R-XTR-186763:r:Downstream signal transduction", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-844456:r:The NLRP3 inflammasome", "R-GGA-1433559:r:Regulation of KIT signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-418594:r:G alpha (i) signalling events", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-GGA-170984:r:ARMS-mediated activation", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-XTR-8853659:r:RET signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-XTR-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-198203:r:PI3K/AKT activation", "R-XTR-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-GGA-416482:r:G alpha (12/13) signalling events", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-SSC-210990:r:PECAM1 interactions", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-5673000:r:RAF activation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-5673000:r:RAF activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-977443:r:GABA receptor activation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-XTR-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-XTR-9013026:r:RHOB GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-418594:r:G alpha (i) signalling events", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-CEL-9748787:r:Azathioprine ADME", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-RNO-177929:r:Signaling by EGFR", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-XTR-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-112399:r:IRS-mediated signalling", "R-HSA-9706369:r:Negative regulation of FLT3", "R-BTA-180292:r:GAB1 signalosome", "R-HSA-3000170:r:Syndecan interactions", "R-XTR-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-5621480:r:Dectin-2 family", "R-XTR-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-XTR-5654695:r:PI-3K cascade:FGFR2", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-BTA-9706369:r:Negative regulation of FLT3", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-XTR-74751:r:Insulin receptor signalling cascade", "R-HSA-373753:r:Nephrin family interactions", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-XTR-109704:r:PI3K Cascade", "R-DME-437239:r:Recycling pathway of L1", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-354192:r:Integrin signaling", "R-DME-3371378:r:Regulation by c-FLIP", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-8853659:r:RET signaling", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-XTR-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-109704:r:PI3K Cascade", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9842663:r:Signaling by LTK", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-9748787:r:Azathioprine ADME", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-525793:r:Myogenesis", "R-MMU-389948:r:Co-inhibition by PD-1", "R-DME-180292:r:GAB1 signalosome", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-9645135:r:STAT5 Activation", "R-CEL-6794361:r:Neurexins and neuroligins", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-GGA-389356:r:Co-stimulation by CD28", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-182971:r:EGFR downregulation", "R-HSA-8866376:r:Reelin signalling pathway", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-GGA-9013026:r:RHOB GTPase cycle", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-373753:r:Nephrin family interactions", "R-RNO-1433559:r:Regulation of KIT signaling", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-112412:r:SOS-mediated signalling", "R-XTR-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-SSC-389356:r:Co-stimulation by CD28", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DRE-430116:r:GP1b-IX-V activation signalling", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-MMU-193648:r:NRAGE signals death through JNK", "R-XTR-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-182971:r:EGFR downregulation", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-9694548:r:Maturation of spike protein", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-112412:r:SOS-mediated signalling", "R-XTR-1295596:r:Spry regulation of FGF signaling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-193648:r:NRAGE signals death through JNK", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-109704:r:PI3K Cascade", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-6807004:r:Negative regulation of MET activity", "R-SPO-9033241:r:Peroxisomal protein import", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-BTA-109704:r:PI3K Cascade", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-201556:r:Signaling by ALK", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-74749:r:Signal attenuation", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-422356:r:Regulation of insulin secretion", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-9013106:r:RHOC GTPase cycle", "R-CEL-373753:r:Nephrin family interactions", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-CEL-912631:r:Regulation of signaling by CBL", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SSC-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1433559:r:Regulation of KIT signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-XTR-180336:r:SHC1 events in EGFR signaling", "R-RNO-201556:r:Signaling by ALK", "R-BTA-9013407:r:RHOH GTPase cycle", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-BTA-912631:r:Regulation of signaling by CBL", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-XTR-5654720:r:PI-3K cascade:FGFR4", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-SPO-9013424:r:RHOV GTPase cycle", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-BTA-9766229:r:Degradation of CDH1", "R-RNO-977443:r:GABA receptor activation", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-XTR-5654710:r:PI-3K cascade:FGFR3", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-SSC-399956:r:CRMPs in Sema3A signaling", "R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-DRE-8853659:r:RET signaling", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DRE-416476:r:G alpha (q) signalling events", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013026:r:RHOB GTPase cycle", "R-XTR-6807004:r:Negative regulation of MET activity", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-XTR-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-XTR-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-210990:r:PECAM1 interactions", "R-SSC-912631:r:Regulation of signaling by CBL", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DRE-9035034:r:RHOF GTPase cycle", "R-DRE-1227986:r:Signaling by ERBB2", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-202433:r:Generation of second messenger molecules", "R-SSC-373753:r:Nephrin family interactions", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-RNO-354192:r:Integrin signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-MMU-5621480:r:Dectin-2 family", "R-HSA-6805567:r:Keratinization", "R-GGA-912631:r:Regulation of signaling by CBL", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-9013424:r:RHOV GTPase cycle", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-74749:r:Signal attenuation", "R-BTA-418885:r:DCC mediated attractive signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-SSC-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-DME-186763:r:Downstream signal transduction", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-XTR-912631:r:Regulation of signaling by CBL", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-191650:r:Regulation of gap junction activity", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-9033241:r:Peroxisomal protein import", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DRE-69231:r:Cyclin D associated events in G1", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-BTA-112399:r:IRS-mediated signalling", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-XTR-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-SCE-354192:r:Integrin signaling", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-XTR-9027284:r:Erythropoietin activates RAS", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-GGA-3928663:r:EPHA-mediated growth cone collapse", "R-XTR-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-XTR-9607240:r:FLT3 Signaling", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CEL-202433:r:Generation of second messenger molecules", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-XTR-8865999:r:MET activates PTPN11", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-SSC-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-9766229:r:Degradation of CDH1", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-3928664:r:Ephrin signaling", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DME-9013148:r:CDC42 GTPase cycle", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-SCE-9033241:r:Peroxisomal protein import", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DRE-5621480:r:Dectin-2 family", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-2029481:r:FCGR activation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-1433559:r:Regulation of KIT signaling", "R-XTR-5654704:r:SHC-mediated cascade:FGFR3", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9031628:r:NGF-stimulated transcription", "R-BTA-2424491:r:DAP12 signaling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-SSC-1227986:r:Signaling by ERBB2", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-GGA-193648:r:NRAGE signals death through JNK", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-9696270:r:RND2 GTPase cycle", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DME-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-167044:r:Signalling to RAS", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5682910:r:LGI-ADAM interactions", "R-MMU-6805567:r:Keratinization", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-9013420:r:RHOU GTPase cycle", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-8941237:r:Invadopodia formation", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-RNO-112399:r:IRS-mediated signalling", "R-XTR-179812:r:GRB2 events in EGFR signaling", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-GGA-9013409:r:RHOJ GTPase cycle", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-5694530:r:Cargo concentration in the ER", "R-XTR-2424491:r:DAP12 signaling", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-XTR-9842663:r:Signaling by LTK", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8853659:r:RET signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-445144:r:Signal transduction by L1", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DRE-177929:r:Signaling by EGFR", "R-HSA-9620244:r:Long-term potentiation", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-XTR-8851907:r:MET activates PI3K/AKT signaling", "R-XTR-167044:r:Signalling to RAS", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-69231:r:Cyclin D associated events in G1", "R-XTR-2871796:r:FCERI mediated MAPK activation", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-422356:r:Regulation of insulin secretion", "R-BTA-389356:r:Co-stimulation by CD28", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-8941237:r:Invadopodia formation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-171007:r:p38MAPK events", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-GGA-210990:r:PECAM1 interactions", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-180292:r:GAB1 signalosome", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-112399:r:IRS-mediated signalling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-373753:r:Nephrin family interactions", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-912631:r:Regulation of signaling by CBL", "R-HSA-420029:r:Tight junction interactions", "R-XTR-112412:r:SOS-mediated signalling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SSC-8866376:r:Reelin signalling pathway", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-5682910:r:LGI-ADAM interactions", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-8851805:r:MET activates RAS signaling", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-170984:r:ARMS-mediated activation", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-XTR-180292:r:GAB1 signalosome", "R-BTA-430116:r:GP1b-IX-V activation signalling", "R-HSA-191650:r:Regulation of gap junction activity", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-XTR-210993:r:Tie2 Signaling", "R-MMU-191650:r:Regulation of gap junction activity", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-167044:r:Signalling to RAS", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DME-69416:r:Dimerization of procaspase-8", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-XTR-8980692:r:RHOA GTPase cycle", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-DRE-9013420:r:RHOU GTPase cycle", "R-GGA-8980692:r:RHOA GTPase cycle", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-MMU-5689901:r:Metalloprotease DUBs", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DME-912631:r:Regulation of signaling by CBL", "R-HSA-2029481:r:FCGR activation", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-210993:r:Tie2 Signaling", "R-BTA-9013409:r:RHOJ GTPase cycle", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-170968:r:Frs2-mediated activation", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-8865999:r:MET activates PTPN11", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-RNO-9748787:r:Azathioprine ADME", "R-DME-5673000:r:RAF activation", "R-CEL-525793:r:Myogenesis", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-XTR-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-8941237:r:Invadopodia formation", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-354192:r:Integrin signaling", "R-RNO-6794361:r:Neurexins and neuroligins", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-6809371:r:Formation of the cornified envelope", "R-DRE-912631:r:Regulation of signaling by CBL", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-186763:r:Downstream signal transduction", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-GGA-186763:r:Downstream signal transduction", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-BTA-6807004:r:Negative regulation of MET activity", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-8866376:r:Reelin signalling pathway", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-BTA-5621480:r:Dectin-2 family", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-9013420:r:RHOU GTPase cycle", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-8853659:r:RET signaling", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-167044:r:Signalling to RAS", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-5673000:r:RAF activation", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-182971:r:EGFR downregulation", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-XTR-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-BTA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-SSC-2029481:r:FCGR activation", "R-MMU-3928664:r:Ephrin signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-BTA-3928664:r:Ephrin signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-DRE-8874081:r:MET activates PTK2 signaling", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-8875656:r:MET receptor recycling", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-XTR-1257604:r:PIP3 activates AKT signaling", "R-BTA-9013424:r:RHOV GTPase cycle", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-RNO-8866376:r:Reelin signalling pathway", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-9927353:r:Co-inhibition by BTLA", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-SCE-9013420:r:RHOU GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9748787:r:Azathioprine ADME", "R-BTA-5576893:r:Phase 2 - plateau phase", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-177929:r:Signaling by EGFR", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-432142:r:Platelet sensitization by LDL", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DRE-210990:r:PECAM1 interactions", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-SCE-392517:r:Rap1 signalling", "R-DME-5625900:r:RHO GTPases activate CIT", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-418885:r:DCC mediated attractive signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-XTR-8875656:r:MET receptor recycling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-354192:r:Integrin signaling", "R-XTR-8851805:r:MET activates RAS signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-XTR-9013424:r:RHOV GTPase cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-GGA-432142:r:Platelet sensitization by LDL", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-389356:r:Co-stimulation by CD28", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1236394:r:Signaling by ERBB4", "R-BTA-1433559:r:Regulation of KIT signaling", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-422356:r:Regulation of insulin secretion", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-DRE-1295596:r:Spry regulation of FGF signaling", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR001453": {"description": "MoaB/Mog domain", "go_ids": [], "go_terms": [], "name": "MoaB/Mog_dom", "pathway_ids": ["R-DRE-196843", "R-DME-947581", "R-CEL-196843", "R-MMU-196843", "R-MMU-947581", "R-RNO-196843", "R-RNO-947581", "R-DDI-947581", "R-HSA-196843", "R-HSA-947581"], "pathways": ["R-DRE-196843:r:Vitamin B2 (riboflavin) metabolism", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-CEL-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-RNO-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-947581:r:Molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR001455": {"description": "TusA-like domain", "go_ids": [], "go_terms": [], "name": "TusA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001456": {"description": "Helper component proteinase", "go_ids": ["GO:0004197", "GO:0006508"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "HC-pro", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR001457": {"description": "NADH:ubiquinone/plastoquinone oxidoreductase, chain 6", "go_ids": ["GO:0008137"], "go_terms": ["GO:0008137:NADH dehydrogenase (ubiquinone) activity:F"], "name": "NADH_UbQ/plastoQ_OxRdtase_su6", "pathway_ids": ["R-HSA-5419276", "R-SSC-5419276", "R-HSA-6799198", "R-MMU-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DRE-611105", "R-SSC-6799198", "R-GGA-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-GGA-5419276", "R-RNO-5419276", "R-GGA-611105", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9837999", "R-BTA-6799198", "R-SSC-611105", "R-BTA-611105"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-SSC-6799198:r:Complex I biogenesis", "R-GGA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-611105:r:Respiratory electron transport", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-6799198:r:Complex I biogenesis", "R-SSC-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR001460": {"description": "Penicillin-binding protein, transpeptidase", "go_ids": ["GO:0008658"], "go_terms": ["GO:0008658:penicillin binding:F"], "name": "PCN-bd_Tpept", "pathway_ids": ["PWY-6471", "PWY-5265", "R-HSA-9913143", "R-HSA-9638771"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)", "R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638771:r:Action of antimicrobials"], "type": "Domain"}, "IPR001461": {"description": "Aspartic peptidase A1", "go_ids": ["GO:0004190", "GO:0006508"], "go_terms": ["GO:0004190:aspartic-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Aspartic_peptidase_A1", "pathway_ids": ["R-SPO-2132295", "R-HSA-6798695", "R-SPO-6798695", "R-HSA-2132295", "R-GGA-2022377", "R-HSA-77387", "R-HSA-977225", "R-CEL-6798695", "R-SCE-6798695", "R-CFA-77387", "R-CFA-1442490", "R-CEL-2132295", "R-CFA-2022377", "R-CFA-5683826", "R-PFA-2132295", "R-MMU-2132295", "R-CFA-2132295", "R-HSA-9018519", "R-HSA-1442490", "R-MMU-5683826", "R-MMU-2022377", "R-DDI-6798695", "R-DDI-5683826", "R-MMU-77387", "R-RNO-2132295", "R-RNO-2022377", "R-GGA-77387", "R-GGA-1442490", "R-HSA-2022377", "R-CEL-5683826", "R-RNO-1442490", "R-RNO-77387", "R-GGA-6798695", "R-GGA-2132295", "R-HSA-5683826", "R-PFA-6798695", "R-SCE-2132295", "R-MMU-6798695", "R-CEL-1442490", "R-CFA-6798695", "R-SSC-5683826", "R-MMU-1442490", "R-RNO-6798695", "R-DDI-2132295"], "pathways": ["R-SPO-2132295:r:MHC class II antigen presentation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-GGA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-977225:r:Amyloid fiber formation", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-CFA-77387:r:Insulin receptor recycling", "R-CFA-1442490:r:Collagen degradation", "R-CEL-2132295:r:MHC class II antigen presentation", "R-CFA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CFA-5683826:r:Surfactant metabolism", "R-PFA-2132295:r:MHC class II antigen presentation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-CFA-2132295:r:MHC class II antigen presentation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-1442490:r:Collagen degradation", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-5683826:r:Surfactant metabolism", "R-MMU-77387:r:Insulin receptor recycling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-GGA-77387:r:Insulin receptor recycling", "R-GGA-1442490:r:Collagen degradation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CEL-5683826:r:Surfactant metabolism", "R-RNO-1442490:r:Collagen degradation", "R-RNO-77387:r:Insulin receptor recycling", "R-GGA-6798695:r:Neutrophil degranulation", "R-GGA-2132295:r:MHC class II antigen presentation", "R-HSA-5683826:r:Surfactant metabolism", "R-PFA-6798695:r:Neutrophil degranulation", "R-SCE-2132295:r:MHC class II antigen presentation", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-1442490:r:Collagen degradation", "R-CFA-6798695:r:Neutrophil degranulation", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-1442490:r:Collagen degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-2132295:r:MHC class II antigen presentation"], "type": "Family"}, "IPR001462": {"description": "Hepadnaviral P protein, C-terminal", "go_ids": ["GO:0004523"], "go_terms": ["GO:0004523:RNA-DNA hybrid ribonuclease activity:F"], "name": "DNApol_viral_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001463": {"description": "Sodium:alanine symporter", "go_ids": ["GO:0006814", "GO:0016020", "GO:0006865", "GO:0005283"], "go_terms": ["GO:0006814:sodium ion transport:P", "GO:0016020:membrane:C", "GO:0006865:amino acid transport:P", "GO:0005283:amino acid:sodium symporter activity:F"], "name": "Na/Ala_symport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001465": {"description": "Malate synthase, TIM barrel domain", "go_ids": [], "go_terms": [], "name": "Malate_synthase_TIM", "pathway_ids": ["PWY-7854", "PWY-7295", "PWY-7118", "PWY-7294"], "pathways": ["PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7295:t:L-arabinose degradation IV", "PWY-7118:t:chitin deacetylation", "PWY-7294:t:D-xylose degradation IV"], "type": "Domain"}, "IPR001466": {"description": "Beta-lactamase-related", "go_ids": [], "go_terms": [], "name": "Beta-lactam-related", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001469": {"description": "ATP synthase, F1 complex, delta/epsilon subunit", "go_ids": ["GO:0015986", "GO:0046933", "GO:0045259"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P", "GO:0046933:proton-transporting ATP synthase activity, rotational mechanism:F", "GO:0045259:proton-transporting ATP synthase complex:C"], "name": "ATP_synth_F1_dsu/esu", "pathway_ids": ["R-BTA-8949613", "R-CEL-163210", "R-MMU-163210", "R-BTA-163210", "R-CEL-8949613", "R-RNO-163210", "R-RNO-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-BTA-8949613:r:Cristae formation", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR001470": {"description": "Bacteriochlorophyll c-binding protein", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "Bchl_c-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001471": {"description": "AP2/ERF domain", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "AP2/ERF_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001474": {"description": "GTP cyclohydrolase I", "go_ids": ["GO:0003934", "GO:0046654"], "go_terms": ["GO:0003934:GTP cyclohydrolase I activity:F", "GO:0046654:tetrahydrofolate biosynthetic process:P"], "name": "GTP_CycHdrlase_I", "pathway_ids": ["PWY-6147", "PWY-7852", "PWY-6703", "PWY-5663", "PWY-6983", "PWY-7442", "R-RNO-1474151", "R-DME-1474151", "R-DDI-1474151", "R-SCE-1474151", "R-CEL-1474151", "R-HSA-1474151", "R-MMU-1474151", "R-SPO-1474151"], "pathways": ["PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-7852:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)", "PWY-6703:t:preQ0 biosynthesis", "PWY-5663:t:erythro-tetrahydrobiopterin biosynthesis I", "PWY-6983:t:threo-tetrahydrobiopterin biosynthesis", "PWY-7442:t:drosopterin and aurodrosopterin biosynthesis", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "type": "Family"}, "IPR001477": {"description": "Viral small hydrophobic protein", "go_ids": [], "go_terms": [], "name": "SH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001478": {"description": "PDZ domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "PDZ", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-MMU-8856828", "R-CEL-181430", "R-HSA-6802952", "R-MMU-9839397", "R-RNO-2028269", "R-BTA-5673001", "R-MMU-3928665", "R-HSA-420029", "R-HSA-8951664", "R-MMU-181430", "R-MMU-8948751", "R-HSA-425397", "R-MMU-199220", "R-RNO-399954", "R-HSA-418990", "R-CFA-8849932", "R-HSA-8863795", "R-HSA-9662360", "R-DME-350411", "R-MMU-5610787", "R-XTR-5610787", "R-RNO-5213460", "R-HSA-9705677", "R-RNO-416476", "R-CEL-182971", "R-HSA-6802955", "R-RNO-193648", "R-MMU-9035034", "R-CFA-9013148", "R-RNO-5682910", "R-DME-350369", "R-HSA-6802948", "R-RNO-4086400", "R-MMU-392517", "R-MMU-5625900", "R-MMU-351906", "R-RNO-9013148", "R-HSA-5627117", "R-CEL-5674135", "R-CEL-212676", "R-RNO-438066", "R-XTR-9013148", "R-MMU-425397", "R-RNO-5663220", "R-HSA-9839397", "R-HSA-9008059", "R-MMU-4641258", "R-XTR-9013404", "R-XTR-4086400", "R-HSA-399954", "R-DME-193648", "R-CFA-399719", "R-MMU-4641262", "R-DRE-9013026", "R-BTA-8980692", "R-DRE-8980692", "R-MMU-9696264", "R-RNO-9013420", "R-HSA-9609736", "R-HSA-392517", "R-HSA-201681", "R-MMU-5674135", "R-RNO-4641262", "R-GGA-399954", "R-DRE-1474228", "R-RNO-8980692", "R-HSA-191650", "R-CEL-210500", "R-XTR-9013026", "R-DRE-9013404", "R-MMU-191650", "R-HSA-8849932", "R-DME-2028269", "R-MMU-418594", "R-RNO-418594", "R-GGA-5627123", "R-CEL-5625900", "R-HSA-9907900", "R-RNO-5666185", "R-RNO-416482", "R-HSA-9013148", "R-HSA-4641262", "R-DRE-6803544", "R-CEL-9013406", "R-RNO-5674135", "R-RNO-9839397", "R-CEL-8856828", "R-BTA-5666185", "R-HSA-399719", "R-HSA-9665249", "R-HSA-3000170", "R-HSA-9696270", "R-DME-6798695", "R-HSA-5666185", "R-MMU-1227986", "R-RNO-210500", "R-MMU-5675482", "R-MMU-9013424", "R-HSA-5099900", "R-MMU-210500", "R-RNO-399719", "R-RNO-3928664", "R-RNO-9013423", "R-XTR-8980692", "R-CEL-201688", "R-HSA-8856825", "R-HSA-3928665", "R-DME-6794361", "R-MMU-9696273", "R-HSA-9725370", "R-RNO-416993", "R-HSA-6798695", "R-MMU-416476", "R-MMU-1222556", "R-MMU-9013106", "R-HSA-8856828", "R-HSA-166016", "R-CEL-5099900", "R-MMU-5099900", "R-MMU-2173791", "R-RNO-416572", "R-CEL-9013409", "R-GGA-2029482", "R-RNO-191650", "R-RNO-190370", "R-CEL-5673001", "R-MMU-416572", "R-DRE-425397", 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"R-CEL-181429", "R-RNO-9839389", "R-HSA-9617324", "R-DME-450728", "R-MMU-4608870", "R-BTA-9907900", "R-XTR-8856828", "R-MMU-9839389", "R-CEL-6794361", "R-MMU-2028269", "R-CEL-5675221", "R-HSA-2173791", "R-HSA-9665246", "R-RNO-5578775", "R-MMU-888590", "R-HSA-1227986", "R-HSA-9665233", "R-XTR-5663220", "R-HSA-983168", "R-HSA-9673324", "R-MMU-2029482", "R-DME-451308", "R-HSA-888590", "R-DME-201688", "R-DRE-9013148", "R-CEL-2028269", "R-HSA-5627123", "R-DME-209440", "R-HSA-438066", "R-MMU-416482", "R-MMU-3928662", "R-CFA-438066", "R-HSA-9013406", "R-CFA-416482", "R-DME-9013423", "R-MMU-399719", "R-HSA-9013409", "R-XTR-8856825", "R-HSA-9665251", "R-RNO-1474228", "R-MMU-9013408", "R-MMU-9013409", "R-RNO-5610787", "R-XTR-4641262", "R-HSA-442982", "R-CEL-888590", "R-SSC-936837", "R-DME-9013148", "R-DRE-5610787", "R-MMU-9013420", "R-HSA-8853659", "R-DME-399954", "R-MMU-9652282", "R-HSA-8942233", "R-HSA-447038", "R-MMU-5673001", "R-HSA-210500", "R-MMU-449836", "R-HSA-1474228", "R-RNO-4641258", "R-DME-9013149", "R-HSA-181430", "R-HSA-182971", "R-CFA-8980692", "R-MMU-4086400", "R-DME-5627123", "R-HSA-416482", "R-BTA-196780", "R-XTR-9013408", "R-HSA-9696264", "R-DRE-8849932", "R-MMU-9013423", "R-BTA-9913351", "R-DME-416482", "R-MMU-193648", "R-MMU-5682910", "R-HSA-9013026", "R-MMU-5627123", "R-CEL-8856825", "R-HSA-212676", "R-MMU-5663220", "R-MMU-5675221", "R-RNO-6798695", "R-CEL-8849932", "R-HSA-9656223", "R-HSA-1839117", "R-DME-983168", "R-MMU-9837999", "R-HSA-416572", "R-HSA-5625900", "R-HSA-392154", "R-MMU-8980692", "R-DRE-438066", "R-RNO-351906", "R-HSA-196780", "R-BTA-9013406", "R-HSA-9665737", "R-HSA-9013106", "R-HSA-199220", "R-HSA-9665348", "R-BTA-9013423", "R-HSA-9013423", "R-HSA-9839389", "R-HSA-181429", "R-DME-9907900", "R-DRE-9696264", "R-MMU-190370", "R-HSA-9692912", "R-CFA-416572", "R-HSA-9837999", "R-RNO-451308", "R-HSA-9032845", "R-MMU-3928664", "R-CEL-9013423", "R-HSA-416993", "R-XTR-8849932", "R-MMU-212676", "R-RNO-181430", "R-RNO-447043", "R-HSA-9841251", "R-XTR-201688", "R-HSA-9913351", "R-HSA-9760173", "R-HSA-936837", "R-DME-350480", "R-HSA-9665250", "R-DME-418594", "R-HSA-190370", "R-MMU-447043", "R-MMU-1660499", "R-HSA-9634285", "R-XTR-9013406", "R-BTA-9013404", "R-CEL-9013420", "R-HSA-5663220", "R-HSA-5682910", "R-MMU-9013149", "R-HSA-202733", "R-XTR-9013106", "R-MMU-182971", "R-RNO-5627123", "R-HSA-1989781", "R-HSA-5674135", "R-DRE-936837", "R-MMU-451308", "R-CEL-9013424", "R-RNO-9013149", "R-CEL-438066", "R-MMU-9013404", "R-HSA-351906", "R-HSA-9013424", "R-DME-4086400", "R-DME-350376", "R-HSA-3928662", "R-CEL-9035034", "R-DME-5099900", "R-DME-9035034", "R-RNO-190373", "R-CFA-451308", "R-RNO-9013424", "R-HSA-9649948", "R-BTA-9837999", "R-RNO-9013406", "R-DME-5663220", "R-MMU-6803544", "R-HSA-9665247", "R-CEL-9013148", "R-CEL-264642", "R-HSA-9664565", "R-DME-438066", "R-HSA-5655302", "R-MMU-420029", "R-MMU-9907900", "R-HSA-9665244", "R-CEL-4641258", "R-HSA-9665686", "R-DME-8980692", "R-RNO-8853659", "R-MMU-166016", "R-MMU-8849932", "R-MMU-438066", "R-MMU-8853659", "R-MMU-5578775", "R-SSC-199220", "R-XTR-4641258", "R-MMU-5627083", "R-RNO-420029", "R-MMU-196780", "R-HSA-9013404", "R-MMU-264642", "R-HSA-9013149", "R-HSA-8980692", "R-CFA-9013106", "R-HSA-9620244", "R-MMU-9913351", "R-RNO-264642", "R-HSA-8948751", "R-RNO-181429", "R-RNO-8849932", "R-DME-5625900", "R-RNO-201688", "R-HSA-449836", "R-HSA-6803544", "R-MMU-8856825", "R-HSA-5368598", "R-RNO-418990", "R-DME-4641258", "R-DME-350368", "R-MMU-201688", "R-HSA-9619665", "R-HSA-416476", "R-CEL-9013149", "R-HSA-9665245", "R-MMU-5213460", "R-BTA-212676", "R-HSA-6802946", "R-XTR-9696264", "R-XTR-9013423", "R-HSA-5578775", "R-RNO-9013106", "R-MMU-936837", "R-HSA-9918481", "R-MMU-5666185", "R-MMU-416993", "R-DRE-199220", "R-HSA-193648", "R-HSA-201688", "R-RNO-4608870", "R-DRE-9013408", "R-HSA-9013420", "R-CEL-9913351", "R-HSA-5627083", "R-HSA-4086400", "R-MMU-6794361", "R-HSA-9662361", "R-DME-9837999", "R-HSA-190373", "R-MMU-181429", "R-XTR-9035034", "R-DME-212676", "R-SSC-425397", "R-HSA-1236394", "R-MMU-418990", "R-BTA-9013408", "R-HSA-5213460", "R-RNO-5625900", "R-DME-8849932", "R-HSA-418594", "R-SCE-9907900", "R-DRE-8853659", "R-HSA-9703465", "R-MMU-9013026", "R-XTR-438066", "R-MMU-983168", "R-HSA-9022699", "R-RNO-5675482", "R-BTA-5610787", "R-MMU-9696270", "R-RNO-888590", "R-CFA-193648", "R-HSA-2028269", "R-HSA-9696273", "R-BTA-425397", "R-HSA-5675221"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9839397:r:TGFBR3 regulates FGF2 signaling", "R-RNO-2028269:r:Signaling by Hippo", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-420029:r:Tight junction interactions", "R-HSA-8951664:r:Neddylation", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-418990:r:Adherens junctions interactions", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-XTR-5610787:r:Hedgehog 'off' state", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-RNO-416476:r:G alpha (q) signalling events", "R-CEL-182971:r:EGFR downregulation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-9035034:r:RHOF GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-RNO-5682910:r:LGI-ADAM interactions", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-4086400:r:PCP/CE pathway", "R-MMU-392517:r:Rap1 signalling", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-MMU-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-4641258:r:Degradation of DVL", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-XTR-4086400:r:PCP/CE pathway", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-193648:r:NRAGE signals death through JNK", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-392517:r:Rap1 signalling", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-GGA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-191650:r:Regulation of gap junction activity", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-XTR-9013026:r:RHOB GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-MMU-191650:r:Regulation of gap junction activity", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-DME-2028269:r:Signaling by Hippo", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-HSA-9907900:r:Proteasome assembly", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-6803544:r:Ion influx/efflux at host-pathogen interface", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-RNO-9839397:r:TGFBR3 regulates FGF2 signaling", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-MMU-1227986:r:Signaling by ERBB2", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-RNO-3928664:r:Ephrin signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-XTR-8980692:r:RHOA GTPase cycle", "R-CEL-201688:r:WNT mediated activation of DVL", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-6794361:r:Neurexins and neuroligins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-191650:r:Regulation of gap junction activity", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-SSC-6803544:r:Ion influx/efflux at host-pathogen interface", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-8853659:r:RET signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-447043:r:Neurofascin interactions", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-CEL-4086400:r:PCP/CE pathway", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-DRE-196780:r:Biotin transport and metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6794361:r:Neurexins and neuroligins", "R-XTR-2028269:r:Signaling by Hippo", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-SSC-196780:r:Biotin transport and metabolism", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-9907900:r:Proteasome assembly", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-CEL-6794361:r:Neurexins and neuroligins", "R-MMU-2028269:r:Signaling by Hippo", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-RNO-5578775:r:Ion homeostasis", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-201688:r:WNT mediated activation of DVL", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-CEL-2028269:r:Signaling by Hippo", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-RNO-5610787:r:Hedgehog 'off' state", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-SSC-936837:r:Ion transport by P-type ATPases", "R-DME-9013148:r:CDC42 GTPase cycle", "R-DRE-5610787:r:Hedgehog 'off' state", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-DME-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-8942233:r:Intestinal infectious diseases", "R-HSA-447038:r:NrCAM interactions", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-4641258:r:Degradation of DVL", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-182971:r:EGFR downregulation", "R-CFA-8980692:r:RHOA GTPase cycle", "R-MMU-4086400:r:PCP/CE pathway", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-BTA-196780:r:Biotin transport and metabolism", "R-XTR-9013408:r:RHOG GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-BTA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-196780:r:Biotin transport and metabolism", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-9907900:r:Proteasome assembly", "R-DRE-9696264:r:RND3 GTPase cycle", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-447043:r:Neurofascin interactions", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-XTR-201688:r:WNT mediated activation of DVL", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-DME-418594:r:G alpha (i) signalling events", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-MMU-447043:r:Neurofascin interactions", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-CEL-9013420:r:RHOU GTPase cycle", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5682910:r:LGI-ADAM interactions", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-XTR-9013106:r:RHOC GTPase cycle", "R-MMU-182971:r:EGFR downregulation", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DRE-936837:r:Ion transport by P-type ATPases", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DME-4086400:r:PCP/CE pathway", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-9035034:r:RHOF GTPase cycle", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-MMU-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-420029:r:Tight junction interactions", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-CEL-4641258:r:Degradation of DVL", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DME-8980692:r:RHOA GTPase cycle", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-8853659:r:RET signaling", "R-MMU-5578775:r:Ion homeostasis", "R-SSC-199220:r:Vitamin B5 (pantothenate) metabolism", "R-XTR-4641258:r:Degradation of DVL", "R-MMU-5627083:r:RHO GTPases regulate CFTR trafficking", "R-RNO-420029:r:Tight junction interactions", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-HSA-9620244:r:Long-term potentiation", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-DME-5625900:r:RHO GTPases activate CIT", "R-RNO-201688:r:WNT mediated activation of DVL", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-RNO-418990:r:Adherens junctions interactions", "R-DME-4641258:r:Degradation of DVL", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-MMU-201688:r:WNT mediated activation of DVL", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-416476:r:G alpha (q) signalling events", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-XTR-9696264:r:RND3 GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DRE-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-201688:r:WNT mediated activation of DVL", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-HSA-4086400:r:PCP/CE pathway", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-XTR-9035034:r:RHOF GTPase cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-SSC-425397:r:Transport of vitamins, nucleosides, and related molecules", 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of Sister Chromatid Cohesion", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-DME-909733:r:Interferon alpha/beta signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9707616:r:Heme signaling", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-180746:r:Nuclear import of Rev protein", "R-DDI-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex"], "type": "Domain"}, "IPR001496": {"description": "SOCS box domain", "go_ids": [], "go_terms": [], "name": "SOCS_box", "pathway_ids": ["R-BTA-983168", "R-RNO-877300", "R-DME-983168", "R-BTA-8951664", "R-GGA-983168", "R-RNO-6785807", "R-HSA-1059683", "R-HSA-8873719", "R-HSA-8951664", "R-DME-8951664", "R-DRE-8951664", "R-RNO-1059683", "R-GGA-8951664", "R-SSC-8951664", "R-RNO-877312", "R-DRE-983168", "R-MMU-8951664", "R-GGA-877300", "R-SSC-9706369", "R-HSA-8849474", "R-HSA-877312", "R-BTA-1059683", "R-HSA-912694", "R-BTA-877300", "R-MMU-909733", "R-BTA-9706369", "R-HSA-1266695", "R-HSA-2586552", "R-MMU-877312", "R-BTA-877312", "R-HSA-9706369", "R-BTA-8849474", "R-BTA-9705462", "R-HSA-166058", "R-GGA-1059683", "R-MMU-8849474", "R-RNO-8849474", "R-MMU-9706369", "R-RNO-9705462", "R-GGA-877312", "R-HSA-983168", "R-HSA-6785807", "R-XTR-8951664", "R-MMU-877300", "R-MMU-9705462", "R-HSA-982772", "R-MMU-8873719", "R-HSA-1433559", "R-MMU-1059683", "R-GGA-909733", "R-HSA-909733", "R-XTR-983168", "R-RNO-909733", "R-HSA-9705462", "R-HSA-877300", "R-RNO-8951664", "R-BTA-909733", "R-MMU-983168", "R-HSA-9674555", "R-RNO-983168", "R-MMU-6785807", "R-HSA-8939242"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-877300:r:Interferon gamma signaling", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8951664:r:Neddylation", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-8873719:r:RAB geranylgeranylation", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-GGA-8951664:r:Neddylation", "R-SSC-8951664:r:Neddylation", "R-RNO-877312:r:Regulation of IFNG signaling", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-GGA-877300:r:Interferon gamma signaling", "R-SSC-9706369:r:Negative regulation of FLT3", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-HSA-877312:r:Regulation of IFNG signaling", "R-BTA-1059683:r:Interleukin-6 signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-BTA-877300:r:Interferon gamma signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-BTA-9706369:r:Negative regulation of FLT3", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-877312:r:Regulation of IFNG signaling", "R-BTA-877312:r:Regulation of IFNG signaling", "R-HSA-9706369:r:Negative regulation of FLT3", "R-BTA-8849474:r:PTK6 Activates STAT3", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-GGA-1059683:r:Interleukin-6 signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-8849474:r:PTK6 Activates STAT3", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-877312:r:Regulation of IFNG signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-XTR-8951664:r:Neddylation", "R-MMU-877300:r:Interferon gamma signaling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-8873719:r:RAB geranylgeranylation", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-RNO-8951664:r:Neddylation", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "type": "Domain"}, "IPR001498": {"description": "Impact, N-terminal", "go_ids": [], "go_terms": [], "name": "Impact_N", "pathway_ids": ["R-HSA-9633012"], "pathways": ["R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR001499": {"description": "GPCR fungal pheromone mating factor, STE3", "go_ids": ["GO:0004932", "GO:0007186", "GO:0016020"], "go_terms": ["GO:0004932:mating-type factor pheromone receptor activity:F", "GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "GPCR_STE3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001500": {"description": "Alpha-1-acid glycoprotein", "go_ids": ["GO:0002682", "GO:0005576"], "go_terms": ["GO:0002682:regulation of immune system process:P", "GO:0005576:extracellular region:C"], "name": "A1A_glycop", "pathway_ids": ["R-HSA-6798695", "R-HSA-114608", "R-MMU-6798695", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR001501": {"description": "Nickel-dependent hydrogenase, large subunit", "go_ids": ["GO:0016151"], "go_terms": ["GO:0016151:nickel cation binding:F"], "name": "Ni-dep_hyd_lsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001503": {"description": "Glycosyl transferase family 10", "go_ids": ["GO:0009101", "GO:0008417", "GO:0016020"], "go_terms": ["GO:0009101:glycoprotein biosynthetic process:P", "GO:0008417:fucosyltransferase activity:F", "GO:0016020:membrane:C"], "name": "Glyco_trans_10", "pathway_ids": ["R-DRE-5173105", "R-RNO-9037629", "R-HSA-975578", "R-DME-975578", "R-HSA-9037629", "R-RNO-5173105", "R-CFA-9037629", "R-CFA-5173105", "R-BTA-9037629", "R-DME-9037629", "R-MMU-5173105", "R-CEL-9037629", "R-MMU-9037629", "R-HSA-5173105", "R-CEL-975578"], "pathways": ["R-DRE-5173105:r:O-linked glycosylation", "R-RNO-9037629:r:Lewis blood group biosynthesis", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-RNO-5173105:r:O-linked glycosylation", "R-CFA-9037629:r:Lewis blood group biosynthesis", "R-CFA-5173105:r:O-linked glycosylation", "R-BTA-9037629:r:Lewis blood group biosynthesis", "R-DME-9037629:r:Lewis blood group biosynthesis", "R-MMU-5173105:r:O-linked glycosylation", "R-CEL-9037629:r:Lewis blood group biosynthesis", "R-MMU-9037629:r:Lewis blood group biosynthesis", "R-HSA-5173105:r:O-linked glycosylation", "R-CEL-975578:r:Reactions specific to the complex N-glycan synthesis pathway"], "type": "Family"}, "IPR001506": {"description": "Peptidase M12A", "go_ids": ["GO:0004222", "GO:0006508"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_M12A", "pathway_ids": ["PWY-8119", "R-HSA-1474228", "R-HSA-2214320", "R-HSA-2243919", "R-HSA-8963896", "R-DME-1650814", "R-CEL-2214320", "R-DRE-2243919", "R-MMU-2243919", "R-MMU-2214320", "R-DME-2243919", "R-HSA-1650814", "R-DME-1474228", "R-MMU-8963896", "R-CEL-1474228", "R-DME-2214320", "R-MMU-1650814", "R-DRE-1650814", "R-CEL-1650814"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-8963896:r:HDL assembly", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-CEL-2214320:r:Anchoring fibril formation", "R-DRE-2243919:r:Crosslinking of collagen fibrils", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-MMU-2214320:r:Anchoring fibril formation", "R-DME-2243919:r:Crosslinking of collagen fibrils", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-8963896:r:HDL assembly", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-DME-2214320:r:Anchoring fibril formation", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DRE-1650814:r:Collagen biosynthesis and modifying enzymes", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes"], "type": "Domain"}, "IPR001507": {"description": "Zona pellucida domain", "go_ids": [], "go_terms": [], "name": "ZP_dom", "pathway_ids": ["R-MMU-9839406", "R-MMU-9839383", "R-HSA-9839406", "R-MMU-163125", "R-MMU-9839397", "R-HSA-201451", "R-HSA-9925561", "R-RNO-190370", "R-HSA-9839389", "R-BTA-2534343", "R-RNO-190373", "R-MMU-190370", "R-MMU-190373", "R-MMU-201451", "R-RNO-201451", "R-RNO-9839389", "R-RNO-2173789", "R-HSA-2173789", "R-MMU-5683826", "R-MMU-446203", "R-MMU-1502540", "R-MMU-2534343", "R-RNO-9839397", "R-MMU-2173789", "R-MMU-9839389", "R-HSA-446203", "R-HSA-9839394", "R-RNO-446203", "R-RNO-9839383", "R-HSA-190373", "R-HSA-9839383", "R-HSA-1502540", "R-SSC-2534343", "R-HSA-190370", "R-RNO-5683826", "R-RNO-163125", "R-HSA-163125", "R-HSA-9839397", "R-HSA-2534343", "R-HSA-5683826", "R-RNO-1502540", "R-RNO-9839406"], "pathways": ["R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-201451:r:Signaling by BMP", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-MMU-201451:r:Signaling by BMP", "R-RNO-201451:r:Signaling by BMP", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-MMU-1502540:r:Signaling by Activin", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-RNO-9839397:r:TGFBR3 regulates FGF2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9839394:r:TGFBR3 expression", "R-RNO-446203:r:Asparagine N-linked glycosylation", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1502540:r:Signaling by Activin", "R-SSC-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-RNO-5683826:r:Surfactant metabolism", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-5683826:r:Surfactant metabolism", "R-RNO-1502540:r:Signaling by Activin", "R-RNO-9839406:r:TGFBR3 regulates activin signaling"], "type": "Domain"}, "IPR001508": {"description": "Ionotropic glutamate receptor, metazoa", "go_ids": ["GO:0038023", "GO:0005216", "GO:0006811", "GO:0016020"], "go_terms": ["GO:0038023:signaling receptor activity:F", "GO:0005216:monoatomic ion channel activity:F", "GO:0006811:monoatomic ion transport:P", 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"R-HSA-451308", "R-HSA-399719", "R-MMU-500657", "R-MMU-8849932", "R-MMU-438066", "R-DME-3928662", "R-RNO-399710", "R-RNO-399719"], "pathways": ["R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9620244:r:Long-term potentiation", "R-RNO-500657:r:Presynaptic function of Kainate receptors", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-399710:r:Activation of AMPA receptors", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-451307:r:Activation of Na-permeable kainate receptors", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DME-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DME-399710:r:Activation of AMPA receptors", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-451307:r:Activation of Na-permeable kainate receptors", "R-RNO-451307:r:Activation of Na-permeable kainate receptors", "R-CFA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-HSA-399710:r:Activation of AMPA receptors", "R-MMU-399710:r:Activation of AMPA receptors", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-500657:r:Presynaptic function of Kainate receptors", "R-CEL-451307:r:Activation of Na-permeable kainate receptors", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-5694530:r:Cargo concentration in the ER", "R-CEL-5694530:r:Cargo concentration in the ER", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-RNO-399710:r:Activation of AMPA receptors", "R-RNO-399719:r:Trafficking of AMPA receptors"], "type": "Family"}, "IPR001509": {"description": "NAD-dependent epimerase/dehydratase", "go_ids": [], "go_terms": [], "name": "Epimerase_deHydtase", "pathway_ids": ["R-HSA-611105", "R-DDI-6787639", "R-BTA-611105", "R-CEL-70370", "R-HSA-6799198", "R-MMU-6787639", "R-BTA-6799198", "R-DME-6787639", "R-HSA-6787639", "R-CEL-6787639"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-DDI-6787639:r:GDP-fucose biosynthesis", "R-BTA-611105:r:Respiratory electron transport", "R-CEL-70370:r:Galactose catabolism", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6787639:r:GDP-fucose biosynthesis", "R-BTA-6799198:r:Complex I biogenesis", "R-DME-6787639:r:GDP-fucose biosynthesis", "R-HSA-6787639:r:GDP-fucose biosynthesis", "R-CEL-6787639:r:GDP-fucose biosynthesis"], "type": "Domain"}, "IPR001510": {"description": "Zinc finger, PARP-type", "go_ids": ["GO:0003677", "GO:0008270"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008270:zinc ion binding:F"], "name": "Znf_PARP", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-MMU-2173795", "R-MMU-5649702", "R-HSA-3108214", "R-HSA-192814", "R-HSA-5696397", "R-DRE-5696400", "R-RNO-5685939", "R-RNO-110362", "R-RNO-3108214", "R-MMU-110381", "R-DRE-5685939", "R-HSA-5649702", "R-DRE-110362", "R-DME-5696394", "R-DRE-5696395", "R-DRE-3108214", "R-MMU-5696395", "R-RNO-2173795", "R-MMU-110362", "R-HSA-2173795", "R-MMU-5685939", "R-HSA-6782210", "R-MMU-5696394", "R-CEL-5696394", "R-MMU-5696400", "R-RNO-5696395", "R-HSA-110362", "R-DME-5696395", "R-HSA-5685939", "R-DRE-5696394", "R-RNO-5696394", "R-HSA-110381", "R-DME-5696400", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-5696394", "R-RNO-5696400", "R-HSA-5696400", "R-MMU-6782210", "R-MMU-3108214", "R-HSA-9913635"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DME-5696400:r:Dual Incision in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR001515": {"description": "Large ribosomal subunit protein eL32", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], 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Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon 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peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CFA-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CFA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001516": {"description": "NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal", "go_ids": [], "go_terms": [], "name": "Proton_antipo_N", "pathway_ids": ["R-HSA-5419276", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-DRE-611105", "R-RNO-6799198", "R-SSC-5419276", "R-SSC-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-RNO-5419276", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9837999", "R-SSC-611105", "R-DRE-5419276"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-RNO-6799198:r:Complex I biogenesis", "R-SSC-5419276:r:Mitochondrial translation termination", "R-SSC-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Domain"}, "IPR001517": {"description": "Luteovirus group 1 coat protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Luteo_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001518": {"description": "Argininosuccinate synthase", "go_ids": ["GO:0004055", "GO:0005524", "GO:0006526"], "go_terms": ["GO:0004055:argininosuccinate synthase activity:F", "GO:0005524:ATP binding:F", "GO:0006526:L-arginine biosynthetic process:P"], "name": "Arginosuc_synth", "pathway_ids": ["PWY-7400", "PWY-4984", "PWY-5", "PWY-4983", "PWY-5154", "R-BTA-70635", "R-MMU-70635", "R-HSA-70635", "R-XTR-70635", "R-HSA-9956520"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-4984:t:urea cycle", "PWY-5:t:canavanine biosynthesis", "PWY-4983:t:nitric oxide biosynthesis II (mammals)", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-BTA-70635:r:Urea cycle", "R-MMU-70635:r:Urea cycle", "R-HSA-70635:r:Urea cycle", "R-XTR-70635:r:Urea cycle", "R-HSA-9956520:r:ASS1 variants cause citrullinemia"], "type": "Family"}, "IPR001519": {"description": "Ferritin", "go_ids": ["GO:0006826", "GO:0006879", "GO:0008199"], "go_terms": ["GO:0006826:iron ion transport:P", "GO:0006879:intracellular iron ion homeostasis:P", "GO:0008199:ferric iron binding:F"], "name": "Ferritin", "pathway_ids": ["R-HSA-6798695", "R-HSA-3000480", "R-RNO-917937", "R-GGA-917937", "R-MMU-432722", "R-BTA-6798695", "R-CFA-432722", "R-HSA-1222449", "R-CFA-917937", "R-GGA-6798695", "R-MMU-917937", "R-BTA-917937", "R-HSA-917937", "R-GGA-432722", "R-MMU-6798695", "R-CFA-6798695", "R-HSA-432722", "R-RNO-6798695", "R-RNO-432722"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-RNO-917937:r:Iron uptake and transport", "R-GGA-917937:r:Iron uptake and transport", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-CFA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-CFA-917937:r:Iron uptake and transport", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-917937:r:Iron uptake and transport", "R-BTA-917937:r:Iron uptake and transport", "R-HSA-917937:r:Iron uptake and transport", "R-GGA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-6798695:r:Neutrophil degranulation", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR001523": {"description": "Paired domain", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Paired_dom", "pathway_ids": ["R-DME-8939245", "R-MMU-3214847", "R-HSA-5617472", "R-HSA-9830364", "R-HSA-210745", "R-MMU-8939245", "R-HSA-9823739", "R-HSA-9830674", "R-HSA-8939245", "R-DME-3214847", "R-HSA-9761174", "R-HSA-3214847", "R-HSA-9856649", "R-HSA-381771", "R-HSA-9834899", "R-HSA-210746", "R-HSA-400511"], "pathways": ["R-DME-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-9823739:r:Formation of the anterior neural plate", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-DME-3214847:r:HATs acetylate histones", "R-HSA-9761174:r:Formation of intermediate mesoderm", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-210746:r:Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Domain"}, "IPR001525": {"description": "C-5 cytosine methyltransferase", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "C5_MeTfrase", "pathway_ids": ["R-HSA-4655427", "R-RNO-3214858", "R-HSA-427413", "R-MMU-212300", "R-HSA-3214858", "R-MMU-3214858", "R-HSA-9710421", "R-RNO-4655427", "R-HSA-9725371", "R-HSA-212300", "R-RNO-212300", "R-HSA-6782315", "R-MMU-4655427", "R-HSA-9845323", "R-HSA-5334118", "R-HSA-9701898"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-HSA-9710421:r:Defective pyroptosis", "R-RNO-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-MMU-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-5334118:r:DNA methylation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling"], "type": "Family"}, "IPR001528": {"description": "Flavivirus non-structural protein NS4B", "go_ids": [], "go_terms": [], "name": "Flavi_NS4B", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR001529": {"description": "DNA-directed RNA polymerase II subunit RPB9-like, zinc ribbon", "go_ids": ["GO:0006351"], "go_terms": ["GO:0006351:DNA-templated transcription:P"], "name": "Zn_ribbon_RPB9", "pathway_ids": ["R-CEL-73779", "R-SSC-674695", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-CEL-72165", "R-MMU-9770562", "R-HSA-73980", "R-CEL-72203", "R-SSC-6782210", "R-DME-72163", "R-SPO-6781823", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-SSC-73779", "R-DME-72086", "R-DME-72203", "R-CEL-9770562", "R-CEL-75953", "R-HSA-76061", "R-SPO-6796648", "R-DME-75953", "R-HSA-749476", "R-CEL-73776", "R-DME-6782135", "R-SSC-75953", "R-SPO-9018519", "R-MMU-72163", "R-HSA-6803529", "R-HSA-167242", "R-CEL-6782210", "R-SSC-9018519", "R-HSA-8851708", "R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-SSC-73776", "R-SSC-6807505", "R-CEL-112382", "R-HSA-9670095", "R-HSA-167160", "R-CEL-6782135", "R-SPO-73779", "R-MMU-72086", "R-SPO-73776", "R-SSC-75955", "R-SCE-73776", "R-HSA-6781827", "R-HSA-5578749", "R-DME-5578749", "R-DME-73779", "R-DME-77075", "R-DME-9770562", "R-DME-73776", "R-MMU-6781823", "R-HSA-203927", "R-SSC-76042", "R-HSA-6782210", "R-HSA-72165", "R-MMU-73776", "R-SSC-6803529", "R-HSA-73780", "R-CEL-72163", "R-HSA-167172", "R-SSC-72165", "R-SCE-73779", "R-DME-113418", "R-SSC-6781823", "R-HSA-76071", "R-HSA-72203", "R-MMU-6796648", "R-SSC-72086", "R-HSA-9770562", "R-CEL-75955", "R-HSA-167243", "R-SSC-6782135", "R-SCE-6781823", "R-SSC-72163", "R-SSC-72203", "R-SSC-77075", "R-SCE-9018519", "R-HSA-167290", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-CEL-9018519", "R-DME-6782210", "R-HSA-674695", "R-HSA-76042", "R-SSC-9770562", "R-SCE-73772", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-SSC-112382", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-DME-6781823", "R-DME-76042", "R-MMU-113418", "R-SPO-6807505", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-SSC-5578749", "R-MMU-73779", "R-HSA-9018519", "R-MMU-76042", "R-SPO-75953", "R-SPO-73762", "R-HSA-5601884", "R-SPO-113418", "R-CEL-6807505", "R-SSC-6796648", "R-DME-674695", "R-DME-9018519", "R-HSA-168325", "R-CEL-113418", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-MMU-9018519", "R-CEL-6781823", "R-DME-6807505", "R-SPO-9770562", "R-HSA-167200", "R-SCE-73762", "R-DME-72165", "R-SCE-674695", "R-MMU-6782210", "R-CEL-6796648", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-MMU-6782135", "R-HSA-76066", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-HSA-167162", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-SCE-6782210", "R-HSA-9918481", "R-SPO-72203", "R-SCE-72203", "R-SCE-6796648", "R-SPO-77075", "R-SCE-113418", "R-SCE-72086", "R-HSA-6782135", "R-CEL-77075", "R-SSC-113418", "R-SCE-77075", "R-SPO-6782135", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SSC-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SSC-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-SSC-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-72086:r:mRNA Capping", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-CEL-9770562:r:mRNA Polyadenylation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-6782135:r:Dual incision in TC-NER", "R-SSC-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SSC-9018519:r:Estrogen-dependent gene expression", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-SSC-73776:r:RNA Polymerase II Promoter Escape", "R-SSC-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-CEL-6782135:r:Dual incision in TC-NER", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72086:r:mRNA Capping", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SSC-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-SSC-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-SSC-6803529:r:FGFR2 alternative splicing", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-SSC-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SSC-72086:r:mRNA Capping", "R-HSA-9770562:r:mRNA Polyadenylation", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SSC-6782135:r:Dual incision in TC-NER", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-SSC-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SSC-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SSC-9770562:r:mRNA Polyadenylation", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SSC-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II 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Polymerase II Transcription Initiation", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SSC-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SSC-113418:r:Formation of the Early Elongation Complex", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Domain"}, "IPR001531": {"description": "Zinc-dependent phospholipase C", "go_ids": ["GO:0004629", "GO:0008270"], "go_terms": ["GO:0004629:C-type glycerophospholipase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Zn_PLipaseC", "pathway_ids": ["PWY-7782", "PWY-7783", "PWY-8052"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7783:t:plasmalogen degradation", "PWY-8052:t:2-arachidonoylglycerol biosynthesis"], "type": "Domain"}, "IPR001533": {"description": "Pterin 4 alpha carbinolamine dehydratase", "go_ids": ["GO:0006729", "GO:0008124"], "go_terms": ["GO:0006729:tetrahydrobiopterin biosynthetic process:P", "GO:0008124:4-alpha-hydroxytetrahydrobiopterin dehydratase activity:F"], "name": "Pterin_deHydtase", "pathway_ids": ["PWY-7158", "PWY-8099", "R-SPO-8964208", "R-RNO-8964208", "R-HSA-8964208", "R-CEL-8964208", "R-MMU-8964208", "R-DDI-8964208", "R-DME-8964208", "R-SCE-8964208", "R-BTA-8964208"], "pathways": ["PWY-7158:t:L-phenylalanine degradation V", "PWY-8099:t:tetrahydropteridine recycling", "R-SPO-8964208:r:Phenylalanine metabolism", "R-RNO-8964208:r:Phenylalanine metabolism", "R-HSA-8964208:r:Phenylalanine metabolism", "R-CEL-8964208:r:Phenylalanine metabolism", "R-MMU-8964208:r:Phenylalanine metabolism", "R-DDI-8964208:r:Phenylalanine metabolism", "R-DME-8964208:r:Phenylalanine metabolism", "R-SCE-8964208:r:Phenylalanine metabolism", "R-BTA-8964208:r:Phenylalanine metabolism"], "type": "Family"}, "IPR001534": {"description": "Transthyretin-like", "go_ids": ["GO:0009986"], "go_terms": ["GO:0009986:cell surface:C"], "name": "Transthyretin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001535": {"description": "Glycoprotein G1/G2", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Glycoprot_G1-G2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001537": {"description": "tRNA/rRNA methyltransferase, SpoU type", "go_ids": ["GO:0003723", "GO:0006396", "GO:0008173"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006396:RNA processing:P", "GO:0008173:RNA methyltransferase activity:F"], "name": "SpoU_MeTrfase", "pathway_ids": ["R-HSA-6793080"], "pathways": ["R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Domain"}, "IPR001538": {"description": "Mannose-6-phosphate isomerase, type II, C-terminal", "go_ids": ["GO:0005976", "GO:0016779"], "go_terms": ["GO:0005976:polysaccharide metabolic process:P", "GO:0016779:nucleotidyltransferase activity:F"], "name": "Man6P_isomerase-2_C", "pathway_ids": ["PWY-5659"], "pathways": ["PWY-5659:t:GDP-mannose biosynthesis"], "type": "Domain"}, "IPR001539": {"description": "Peptidase U32", "go_ids": [], "go_terms": [], "name": "Peptidase_U32", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001542": {"description": "Defensin, invertebrate/fungal", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "Defensin_invertebrate/fungal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001543": {"description": "Flagellar motor switch protein FliN-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FliN-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001544": {"description": "Aminotransferase class IV", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Aminotrans_IV", "pathway_ids": ["R-BTA-70895", "R-SPO-70895", "R-MMU-70895", "R-CEL-70895", "R-DDI-70895", "R-HSA-70895", "R-SCE-70895", "R-RNO-70895"], "pathways": ["R-BTA-70895:r:Branched-chain amino acid catabolism", "R-SPO-70895:r:Branched-chain amino acid catabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-SCE-70895:r:Branched-chain amino acid catabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Family"}, "IPR001545": {"description": "Gonadotropin, beta subunit", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Gonadotropin_bsu", "pathway_ids": ["R-HSA-975578", "R-SSC-193993", "R-SSC-209968", "R-RNO-193993", "R-BTA-8866910", "R-BTA-375281", "R-RNO-193048", "R-HSA-209968", "R-SSC-8866910", "R-GGA-209968", "R-HSA-193993", "R-HSA-8866910", "R-GGA-209822", "R-HSA-193048", "R-SSC-975578", "R-MMU-193048", "R-BTA-193993", "R-RNO-8866910", "R-RNO-209968", "R-GGA-375281", "R-RNO-375281", "R-BTA-209968", "R-HSA-418555", "R-BTA-975578", "R-MMU-375281", "R-SSC-193048", "R-MMU-193993", "R-MMU-8866910", "R-SSC-375281", "R-BTA-193048", "R-HSA-375281", "R-HSA-209822", "R-SSC-209822", "R-GGA-418555", "R-BTA-418555", "R-MMU-209822", "R-RNO-209822", "R-MMU-209968", "R-MMU-975578", "R-MMU-418555", "R-BTA-209822"], "pathways": ["R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", 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receptors", "R-RNO-209968:r:Thyroxine biosynthesis", "R-GGA-375281:r:Hormone ligand-binding receptors", "R-RNO-375281:r:Hormone ligand-binding receptors", "R-BTA-209968:r:Thyroxine biosynthesis", "R-HSA-418555:r:G alpha (s) signalling events", "R-BTA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-375281:r:Hormone ligand-binding receptors", "R-SSC-193048:r:Androgen biosynthesis", "R-MMU-193993:r:Mineralocorticoid biosynthesis", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-SSC-375281:r:Hormone ligand-binding receptors", "R-BTA-193048:r:Androgen biosynthesis", "R-HSA-375281:r:Hormone ligand-binding receptors", "R-HSA-209822:r:Glycoprotein hormones", "R-SSC-209822:r:Glycoprotein hormones", "R-GGA-418555:r:G alpha (s) signalling events", "R-BTA-418555:r:G alpha (s) signalling events", "R-MMU-209822:r:Glycoprotein hormones", "R-RNO-209822:r:Glycoprotein hormones", "R-MMU-209968:r:Thyroxine biosynthesis", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-418555:r:G alpha (s) signalling events", "R-BTA-209822:r:Glycoprotein hormones"], "type": "Family"}, "IPR001547": {"description": "Glycoside hydrolase, family 5", "go_ids": ["GO:0000272", "GO:0004553"], "go_terms": ["GO:0000272:polysaccharide catabolic process:P", "GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "Glyco_hydro_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001548": {"description": "Peptidase M2, peptidyl-dipeptidase A", "go_ids": ["GO:0006508", "GO:0008237", "GO:0008241", "GO:0016020"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008237:metallopeptidase activity:F", "GO:0008241:peptidyl-dipeptidase activity:F", "GO:0016020:membrane:C"], "name": "Peptidase_M2", "pathway_ids": ["R-SSC-2022377", "R-HSA-9678110", "R-HSA-9733458", "R-BTA-2022377", "R-DME-2022377", "R-RNO-2022377", "R-HSA-9694614", "R-HSA-9679191", "R-HSA-2022377", 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shuttle", "R-DME-70268:r:Pyruvate metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-DRE-70268:r:Pyruvate metabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SSC-9856872:r:Malate-aspartate shuttle", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-RNO-9861718:r:Regulation of pyruvate metabolism"], "type": "Family"}, "IPR001558": {"description": "HIV negative factor Nef", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "HIV_Nef", "pathway_ids": ["R-HSA-173107", "R-HSA-164940", "R-HSA-164944", "R-HSA-167590", "R-HSA-175474", "R-HSA-164939", "R-HSA-162585", "R-HSA-162588", "R-HSA-162599", "R-HSA-182218"], "pathways": ["R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-HSA-164944:r:Nef and signal transduction", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-164939:r:Nef mediated downregulation of CD28 cell surface expression", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-162599:r:Late Phase of HIV Life Cycle", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Family"}, "IPR001559": {"description": "Phosphotriesterase", "go_ids": ["GO:0008270", "GO:0009056"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0009056:catabolic process:P"], "name": "Phosphotriesterase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001561": {"description": "Influenza matrix M1, N-terminal", "go_ids": ["GO:0003723", "GO:0005198"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005198:structural molecule activity:F"], "name": "Flu_matrix_M1_N", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168288", "R-HSA-168275", "R-HSA-168316", "R-HSA-168298", "R-HSA-168330", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-168298:r:Release", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Domain"}, "IPR001562": {"description": "Zinc finger, Btk motif", "go_ids": ["GO:0035556"], "go_terms": ["GO:0035556:intracellular signal transduction:P"], "name": "Znf_Btk_motif", "pathway_ids": ["R-HSA-5663213", "R-MMU-416476", "R-MMU-8964315", "R-HSA-202433", "R-DME-5658442", "R-HSA-416476", "R-HSA-1660499", "R-DME-2424491", "R-DME-111465", "R-MMU-5663213", "R-DME-1660499", "R-DME-2871809", "R-MMU-512988", "R-DME-416476", "R-MMU-5658442", "R-HSA-512988", "R-MMU-111465", "R-MMU-202433", "R-MMU-1433557", "R-HSA-166058", "R-HSA-983695", "R-HSA-2424491", "R-HSA-2871809", "R-HSA-416482", "R-HSA-9679191", "R-MMU-983695", "R-HSA-1433557", "R-HSA-2029482", "R-DME-512988", "R-MMU-2029482", "R-MMU-1660499", "R-HSA-5658442", "R-MMU-2871809", "R-RNO-5658442", "R-MMU-416482", "R-DME-416482", "R-MMU-2424491", "R-HSA-111465", "R-HSA-5603041", "R-HSA-1236974", "R-HSA-5602498", "R-HSA-9664422", "R-HSA-8964315"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-202433:r:Generation of second messenger molecules", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-2424491:r:DAP12 signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-8964315:r:G beta:gamma signalling through BTK"], "type": "Conserved_site"}, "IPR001563": {"description": "Peptidase S10, serine carboxypeptidase", "go_ids": ["GO:0004185", "GO:0006508"], "go_terms": ["GO:0004185:serine-type carboxypeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_S10", "pathway_ids": ["R-HSA-6798695", "R-MMU-9840310", "R-HSA-2132295", "R-HSA-9840310", "R-MMU-4085001", "R-MMU-2132295", "R-CEL-6798695", "R-HSA-4341670", "R-MMU-6798695", "R-HSA-4085001", "R-CEL-2132295"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-MMU-4085001:r:Sialic acid metabolism", "R-MMU-2132295:r:MHC class II antigen presentation", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-4341670:r:Defective NEU1 causes sialidosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-4085001:r:Sialic acid metabolism", "R-CEL-2132295:r:MHC class II antigen presentation"], "type": "Family"}, "IPR001567": {"description": "Peptidase M3A/M3B catalytic domain", "go_ids": ["GO:0004222", "GO:0006508"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_M3A_M3B_dom", "pathway_ids": ["R-DDI-983168", "R-SSC-375276", "R-RNO-375276", "R-HSA-375276", "R-MMU-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-375276"], "pathways": ["R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-375276:r:Peptide ligand-binding receptors"], "type": "Domain"}, "IPR001568": {"description": "Ribonuclease T2-like", "go_ids": ["GO:0003723", "GO:0033897"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0033897:ribonuclease T2 activity:F"], "name": "RNase_T2-like", "pathway_ids": ["R-CEL-6798695", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-6798695", "R-DRE-6798695"], "pathways": ["R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR001569": {"description": "Large ribosomal subunit protein eL37", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL37", "pathway_ids": ["R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-SPO-9954709", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-RNO-975957", "R-BTA-156827", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-HSA-72706", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DME-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001570": {"description": "Peptidase M4, C-terminal", "go_ids": ["GO:0004222"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F"], "name": "Peptidase_M4_C_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001573": {"description": "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif", "go_ids": ["GO:0005516"], "go_terms": ["GO:0005516:calmodulin binding:F"], "name": "AKAP_WSK", "pathway_ids": ["R-HSA-9013405", "R-MMU-9035034", "R-HSA-399719", "R-HSA-381676", "R-HSA-9035034", "R-RNO-9035034", "R-RNO-399719", "R-HSA-9010642", "R-MMU-399719"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-MMU-399719:r:Trafficking of AMPA receptors"], "type": "Domain"}, "IPR001574": {"description": "Ribosome-inactivating protein", "go_ids": ["GO:0017148", "GO:0030598"], "go_terms": ["GO:0017148:negative regulation of translation:P", "GO:0030598:rRNA N-glycosylase activity:F"], "name": "Ribosome_inactivat_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001576": {"description": "Phosphoglycerate kinase", "go_ids": ["GO:0004618", "GO:0006096"], "go_terms": ["GO:0004618:phosphoglycerate kinase activity:F", "GO:0006096:glycolytic process:P"], "name": "Phosphoglycerate_kinase", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-6886", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-MMU-70171", "R-RNO-70263", "R-SCE-70171", "R-SSC-70263", "R-BTA-70171", "R-DME-70171", "R-PFA-70263", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-DME-70263", "R-PFA-70171", "R-DDI-70263", "R-RNO-70171", "R-GGA-352882", "R-SSC-70171", "R-HSA-70263", "R-CEL-70263", "R-BTA-70263", "R-SCE-70263", "R-HSA-9636667", "R-HSA-70171", "R-SPO-70171", "R-SPO-70263"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-RNO-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-SSC-70263:r:Gluconeogenesis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-PFA-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-PFA-70171:r:Glycolysis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-SSC-70171:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Family"}, "IPR001577": {"description": "Peptidase M8, leishmanolysin", "go_ids": ["GO:0004222", "GO:0006508", "GO:0007155", "GO:0016020"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0007155:cell adhesion:P", "GO:0016020:membrane:C"], "name": "Peptidase_M8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001578": {"description": "Peptidase C12, ubiquitin carboxyl-terminal hydrolase", "go_ids": ["GO:0006511", "GO:0004843"], "go_terms": ["GO:0006511:ubiquitin-dependent protein catabolic process:P", "GO:0004843:cysteine-type deubiquitinase activity:F"], "name": "Peptidase_C12_UCH", "pathway_ids": ["R-BTA-8951664", "R-SSC-5689603", "R-SCE-5689603", "R-HSA-8951664", "R-DME-8951664", "R-RNO-5693565", "R-PFA-8866652", "R-RNO-8866652", "R-HSA-5693565", "R-MMU-8866652", "R-DDI-5693565", "R-DME-8866652", "R-DDI-8951664", "R-MMU-5693565", "R-MMU-8951664", "R-RNO-5689603", "R-HSA-8866652", "R-CEL-5689603", "R-DDI-5689603", "R-DME-5689603", "R-MMU-5689603", "R-HSA-2173788", "R-PFA-5689603", "R-SPO-5689603", "R-DRE-5689603", "R-BTA-5689603", "R-SCE-8951664", "R-BTA-8866652", "R-RNO-8951664", "R-SPO-8951664", "R-HSA-5689603", "R-PFA-8951664", "R-DDI-8866652", "R-XTR-5689603"], "pathways": ["R-BTA-8951664:r:Neddylation", "R-SSC-5689603:r:UCH proteinases", "R-SCE-5689603:r:UCH proteinases", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-PFA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-8951664:r:Neddylation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-8951664:r:Neddylation", "R-RNO-5689603:r:UCH proteinases", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-CEL-5689603:r:UCH proteinases", "R-DDI-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-PFA-5689603:r:UCH proteinases", "R-SPO-5689603:r:UCH proteinases", "R-DRE-5689603:r:UCH proteinases", "R-BTA-5689603:r:UCH proteinases", "R-SCE-8951664:r:Neddylation", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-5689603:r:UCH proteinases", "R-PFA-8951664:r:Neddylation", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-XTR-5689603:r:UCH proteinases"], "type": "Domain"}, "IPR001580": {"description": "Calreticulin/calnexin", "go_ids": ["GO:0005509", "GO:0005783", "GO:0006457"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0005783:endoplasmic reticulum:C", "GO:0006457:protein folding:P"], "name": "Calret/calnex", "pathway_ids": ["R-HSA-9683686", "R-HSA-2132295", "R-RNO-983170", "R-HSA-3000484", "R-HSA-3000480", "R-HSA-9694548", "R-CEL-901042", "R-MMU-9020956", "R-RNO-9020956", "R-SPO-901042", "R-MMU-3000480", "R-DME-901042", "R-RNO-901042", "R-MMU-2132295", "R-RNO-9768727", "R-HSA-901042", "R-HSA-8984722", "R-RNO-2132295", "R-HSA-381183", "R-SSC-901042", "R-MMU-8984722", "R-MMU-9768727", "R-HSA-9918432", "R-DDI-901042", "R-MMU-901042", "R-RNO-8984722", "R-SCE-901042", "R-HSA-983170", "R-SSC-3000480", "R-SSC-983170", "R-MMU-983170", "R-HSA-168316", "R-HSA-1236974", "R-HSA-9768727", "R-RNO-3000480", "R-HSA-9020956"], "pathways": ["R-HSA-9683686:r:Maturation of spike protein", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-9694548:r:Maturation of spike protein", "R-CEL-901042:r:Calnexin/calreticulin cycle", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-9020956:r:Interleukin-27 signaling", "R-SPO-901042:r:Calnexin/calreticulin cycle", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-DME-901042:r:Calnexin/calreticulin cycle", "R-RNO-901042:r:Calnexin/calreticulin cycle", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-381183:r:ATF6 (ATF6-alpha) activates chaperone genes", "R-SSC-901042:r:Calnexin/calreticulin cycle", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DDI-901042:r:Calnexin/calreticulin cycle", "R-MMU-901042:r:Calnexin/calreticulin cycle", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-SCE-901042:r:Calnexin/calreticulin cycle", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SSC-3000480:r:Scavenging by Class A Receptors", "R-SSC-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-9020956:r:Interleukin-27 signaling"], "type": "Family"}, "IPR001581": {"description": "Leukemia inhibitory factor /oncostatin", "go_ids": ["GO:0005125", "GO:0005576", "GO:0006955"], "go_terms": ["GO:0005125:cytokine activity:F", "GO:0005576:extracellular region:C", "GO:0006955:immune response:P"], "name": "Leukemia_IF/oncostatin", "pathway_ids": ["R-MMU-6788467", "R-RNO-6788467", "R-BTA-6788467", "R-HSA-6788467", "R-HSA-6785807", "R-HSA-6783783"], "pathways": ["R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-BTA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6783783:r:Interleukin-10 signaling"], "type": "Family"}, "IPR001584": {"description": "Integrase, catalytic core", "go_ids": ["GO:0015074"], "go_terms": ["GO:0015074:DNA integration:P"], "name": "Integrase_cat-core", "pathway_ids": ["R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-164843", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164525", "R-HSA-173107", "R-HSA-162594"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Domain"}, "IPR001585": {"description": "Transaldolase/Fructose-6-phosphate aldolase", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "TAL/FSA", "pathway_ids": ["PWY-1861", "PWY-5723", "R-MMU-71336", "R-RNO-163754", "R-SPO-163754", "R-HSA-71336", "R-SSC-71336", "R-HSA-6791055", "R-DDI-163754", "R-DDI-71336", "R-HSA-8950505", "R-RNO-71336", "R-MMU-163754", "R-HSA-9818028", "R-SCE-71336", "R-DME-71336", "R-SSC-163754", "R-HSA-6791462", "R-SCE-163754", "R-DME-163754", "R-HSA-163754", "R-SPO-71336"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-5723:t:Rubisco shunt", "R-MMU-71336:r:Pentose phosphate pathway", "R-RNO-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-SPO-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-HSA-71336:r:Pentose phosphate pathway", "R-SSC-71336:r:Pentose phosphate pathway", "R-HSA-6791055:r:TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P", "R-DDI-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-DDI-71336:r:Pentose phosphate pathway", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-71336:r:Pentose phosphate pathway", "R-MMU-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-SCE-71336:r:Pentose phosphate pathway", "R-DME-71336:r:Pentose phosphate pathway", "R-SSC-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-HSA-6791462:r:TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P", "R-SCE-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-DME-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-HSA-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-SPO-71336:r:Pentose phosphate pathway"], "type": "Family"}, "IPR001588": {"description": "Casein, alpha/beta", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Casein", "pathway_ids": ["R-RNO-5223345", "R-MMU-5223345", "R-BTA-5223345", "R-HSA-9927426", "R-HSA-1251985"], "pathways": ["R-RNO-5223345:r:Miscellaneous transport and binding events", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-BTA-5223345:r:Miscellaneous transport and binding events", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-HSA-1251985:r:Nuclear signaling by ERBB4"], "type": "Family"}, "IPR001590": {"description": "Peptidase M12B, ADAM/reprolysin", "go_ids": ["GO:0004222", "GO:0006508"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_M12B", "pathway_ids": ["PWY-8119", "R-HSA-6798695", "R-RNO-1474228", "R-CEL-6798695", "R-BTA-6798695", "R-HSA-75893", "R-SSC-1474228", "R-RNO-193692", "R-MMU-8957275", "R-HSA-1650814", "R-BTA-8957275", "R-HSA-2979096", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-HSA-177929", "R-HSA-9013507", "R-HSA-2691232", "R-HSA-381426", "R-MMU-1474228", "R-MMU-75893", "R-HSA-1474228", "R-MMU-2534343", "R-SSC-381426", "R-BTA-1474228", "R-HSA-9845619", "R-RNO-9013507", "R-MMU-9762292", "R-HSA-982772", "R-RNO-381426", "R-RNO-5173214", "R-HSA-75892", "R-HSA-2660826", "R-HSA-8941237", "R-MMU-5173214", "R-MMU-5682910", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-2644606", "R-HSA-193692", "R-CEL-5173214", "R-RNO-6798695", "R-SPO-6798695", "R-SSC-6798695", "R-HSA-2122948", "R-HSA-9662834", "R-HSA-977225", "R-HSA-1251985", "R-BTA-5173214", "R-HSA-9845621", "R-SPO-8941237", "R-MMU-193692", "R-CEL-1474228", "R-HSA-5362798", "R-HSA-9013700", "R-MMU-9013507", "R-MMU-8941237", "R-RNO-8957275", "R-BTA-381426", "R-RNO-75893", "R-HSA-1442490", "R-BTA-1650814", "R-RNO-8941237", "R-SSC-8957275", "R-HSA-5083635", "R-HSA-2894862", "R-HSA-5173214", "R-HSA-2534343", "R-MMU-1650814", "R-HSA-3928665", "R-HSA-8957275", "R-HSA-5682910"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-75893:r:TNF signaling", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-MMU-75893:r:TNF signaling", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-8941237:r:Invadopodia formation", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-CEL-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-SPO-8941237:r:Invadopodia formation", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-8941237:r:Invadopodia formation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-75893:r:TNF signaling", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-8941237:r:Invadopodia formation", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5682910:r:LGI-ADAM interactions"], "type": "Domain"}, "IPR001592": {"description": "Potyvirus coat protein", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Poty_coat", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Family"}, "IPR001593": {"description": "Small ribosomal subunit protein eS1", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eS1", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-PFA-72689", "R-HSA-9010553", "R-SPO-9954714", "R-DME-6791226", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-HSA-72695", "R-DME-72706", "R-RNO-72695", "R-MMU-72706", "R-HSA-975956", "R-BTA-72689", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-PFA-72702", "R-XTR-9954716", "R-CEL-72706", "R-BTA-72695", "R-XTR-1799339", "R-PFA-9954716", "R-CEL-9954714", "R-CEL-9954716", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-SPO-975956", "R-BTA-156827", "R-HSA-9633012", "R-RNO-156827", 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translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-PFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72649:r:Translation initiation complex formation", "R-PFA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-PFA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-PFA-5689880:r:Ub-specific processing proteases", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S 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enhanced by the Exon Junction Complex (EJC)", "R-PFA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72649:r:Translation initiation complex formation", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-PFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-PFA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "type": "Family"}, "IPR001594": {"description": "Palmitoyltransferase, DHHC domain", "go_ids": ["GO:0016409"], "go_terms": ["GO:0016409:palmitoyltransferase activity:F"], "name": "Palmitoyltrfase_DHHC", "pathway_ids": ["R-DRE-5683826", "R-BTA-203615", "R-HSA-8963896", "R-MMU-9648002", "R-HSA-9694548", "R-BTA-9648002", "R-RNO-9009391", "R-MMU-203615", "R-MMU-9009391", "R-RNO-5683826", "R-BTA-9009391", "R-DDI-9648002", "R-HSA-203615", "R-DDI-203615", "R-DME-9648002", "R-SPO-203615", "R-MMU-8963896", "R-HSA-9009391", "R-DRE-9009391", "R-HSA-5683826", "R-SCE-203615", "R-HSA-9648002", "R-MMU-5683826", "R-DRE-8963896"], "pathways": ["R-DRE-5683826:r:Surfactant metabolism", "R-BTA-203615:r:eNOS activation", "R-HSA-8963896:r:HDL assembly", "R-MMU-9648002:r:RAS processing", "R-HSA-9694548:r:Maturation of spike protein", "R-BTA-9648002:r:RAS processing", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203615:r:eNOS activation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5683826:r:Surfactant metabolism", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-9648002:r:RAS processing", "R-HSA-203615:r:eNOS activation", "R-DDI-203615:r:eNOS activation", "R-DME-9648002:r:RAS processing", "R-SPO-203615:r:eNOS activation", "R-MMU-8963896:r:HDL assembly", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5683826:r:Surfactant metabolism", "R-SCE-203615:r:eNOS activation", "R-HSA-9648002:r:RAS processing", "R-MMU-5683826:r:Surfactant metabolism", "R-DRE-8963896:r:HDL assembly"], "type": "Domain"}, "IPR001595": {"description": "Uncharacterized lipoprotein MG439-like", "go_ids": [], "go_terms": [], "name": "Lipoprotein_MG439-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001597": {"description": "Aromatic amino acid beta-eliminating lyase/threonine aldolase", "go_ids": ["GO:0006520", "GO:0016829"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0016829:lyase activity:F"], "name": "ArAA_b-elim_lyase/Thr_aldolase", "pathway_ids": ["R-MMU-6783984", "R-HSA-6783984"], "pathways": ["R-MMU-6783984:r:Glycine degradation", "R-HSA-6783984:r:Glycine degradation"], "type": "Domain"}, "IPR001599": {"description": "Alpha-2-macroglobulin", "go_ids": ["GO:0004866"], "go_terms": ["GO:0004866:endopeptidase inhibitor activity:F"], "name": "Macroglobln_a2", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-MMU-163125", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-163125", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR001602": {"description": "UPF0047 protein YjbQ-like", "go_ids": [], "go_terms": [], "name": "UPF0047_YjbQ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001604": {"description": "DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain", "go_ids": ["GO:0003676", "GO:0016787", "GO:0046872"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0016787:hydrolase activity:F", "GO:0046872:metal ion binding:F"], "name": "Endo_G_ENPP1-like_dom", "pathway_ids": ["R-RNO-196843", "R-HSA-114608", "R-HSA-199220", "R-MMU-196843", "R-HSA-196843", "R-HSA-9913635"], "pathways": ["R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-114608:r:Platelet degranulation", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR001606": {"description": "ARID DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "ARID_dom", "pathway_ids": ["R-DME-8939243", "R-DME-9933946", "R-MMU-9933946", "R-MMU-9933937", "R-HSA-427413", "R-MMU-3214815", "R-MMU-212300", "R-HSA-9764790", "R-DME-9934037", "R-HSA-3214858", "R-HSA-9934037", "R-RNO-3214815", "R-SPO-3214815", "R-MMU-8866911", "R-MMU-3214842", "R-HSA-9845323", "R-DME-3214858", "R-DME-9933937", "R-CEL-3214842", "R-DRE-212300", "R-DRE-8866911", "R-HSA-8866911", "R-MMU-9934037", "R-DRE-3214842", "R-DME-8866911", "R-DME-212300", "R-HSA-3214842", "R-HSA-9933939", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-9824585", "R-MMU-3214858", "R-MMU-8939243", "R-SCE-3214815", "R-HSA-212300", "R-HSA-8939243", "R-HSA-9933937", "R-HSA-9821002", "R-HSA-9933946", "R-HSA-6804116"], "pathways": ["R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-RNO-3214815:r:HDACs deacetylate histones", "R-SPO-3214815:r:HDACs deacetylate histones", "R-MMU-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-3214858:r:RMTs methylate histone arginines", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-CEL-3214842:r:HDMs demethylate histones", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DRE-3214842:r:HDMs demethylate histones", "R-DME-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-SCE-3214815:r:HDACs deacetylate histones", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "type": "Domain"}, "IPR001607": {"description": "Zinc finger, UBP-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_UBP", "pathway_ids": ["R-HSA-3371511", "R-HSA-9646399", "R-CEL-8951936", "R-BTA-5689880", "R-HSA-5689880", "R-HSA-9010553", "R-MMU-9010553", "R-CEL-5673000", "R-MMU-5620920", "R-MMU-8866652", "R-MMU-8948751", "R-SPO-9664873", "R-DRE-5696395", "R-MMU-5689880", "R-BTA-9010553", "R-HSA-5673000", "R-MMU-5696395", "R-HSA-8866652", "R-HSA-6802946", "R-HSA-9649948", "R-MMU-3371511", "R-CEL-4551638", "R-SPO-983168", "R-HSA-8878166", "R-HSA-9615710", "R-XTR-5689880", "R-HSA-6802955", "R-HSA-2122947", "R-DDI-5689880", "R-DRE-5689880", "R-BTA-8948751", "R-DRE-8948751", "R-GGA-8948751", "R-CEL-5675221", "R-MMU-72163", "R-DDI-8948751", "R-HSA-2894862", "R-MMU-5673000", "R-DME-5689880", "R-HSA-350054", "R-RNO-5689880", "R-GGA-5689880", "R-HSA-72163", "R-MMU-9646399", "R-HSA-5620920", "R-MMU-350054", "R-HSA-5696395", "R-HSA-8948751", "R-HSA-9613829", "R-HSA-3214847", "R-HSA-2644606", "R-HSA-8940973", "R-MMU-5675221", "R-DDI-8866652", "R-HSA-5675221"], "pathways": ["R-HSA-3371511:r:HSF1 activation", "R-HSA-9646399:r:Aggrephagy", "R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-5673000:r:RAF activation", "R-MMU-5620920:r:Cargo trafficking to the periciliary membrane", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-SPO-9664873:r:Pexophagy", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-5673000:r:RAF activation", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-3371511:r:HSF1 activation", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-9615710:r:Late endosomal microautophagy", "R-XTR-5689880:r:Ub-specific processing proteases", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-MMU-5673000:r:RAF activation", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-RNO-5689880:r:Ub-specific processing proteases", "R-GGA-5689880:r:Ub-specific processing proteases", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9646399:r:Aggrephagy", "R-HSA-5620920:r:Cargo trafficking to the periciliary membrane", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR001608": {"description": "Alanine racemase, N-terminal", "go_ids": [], "go_terms": [], "name": "Ala_racemase_N", "pathway_ids": ["PWY-7383", "PWY-8040", "PWY-8443", "PWY-8072"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-8443:t:cyclosporin A biosynthesis", "PWY-8072:t:alanine racemization"], "type": "Domain"}, "IPR001609": {"description": "Myosin head, motor domain-like", "go_ids": ["GO:0003774", "GO:0005524", "GO:0016459"], "go_terms": ["GO:0003774:cytoskeletal motor activity:F", "GO:0005524:ATP binding:F", "GO:0016459:myosin complex:C"], "name": "Myosin_head_motor_dom-like", "pathway_ids": ["R-RNO-9013026", "R-DME-190873", "R-HSA-9013422", "R-HSA-9013418", "R-MMU-9013106", "R-HSA-264876", "R-CEL-2453902", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-445355", "R-DME-445355", "R-HSA-9013425", "R-MMU-9013422", "R-MMU-9013420", "R-HSA-432040", "R-HSA-9662360", "R-DME-2453902", "R-RNO-9013424", "R-SCE-9013425", "R-SCE-9013420", "R-BTA-5250924", "R-HSA-5655302", "R-MMU-9013419", "R-MMU-9035034", "R-MMU-5250924", "R-RNO-9824585", "R-MMU-390522", "R-MMU-2453902", "R-HSA-2029482", "R-RNO-9013148", "R-HSA-373752", "R-GGA-9824585", "R-MMU-432040", "R-HSA-9013149", "R-HSA-8980692", "R-SPO-5627123", "R-HSA-1445148", "R-SPO-190873", "R-MMU-9013149", "R-HSA-9013026", "R-DRE-9013026", "R-DRE-8980692", "R-DDI-5627123", "R-MMU-5627123", "R-MMU-9013418", "R-DDI-9013418", "R-HSA-1839117", "R-HSA-416572", "R-HSA-5625900", "R-HSA-9662834", "R-RNO-9035034", "R-MMU-8980692", "R-HSA-190873", "R-RNO-8980692", "R-SCE-5627123", "R-HSA-5625740", "R-HSA-9013106", "R-MMU-9013148", "R-DDI-9013422", "R-RNO-2029482", "R-BTA-5627123", "R-HSA-9725370", "R-MMU-190873", "R-MMU-9824585", "R-HSA-9035034", "R-HSA-9013148", "R-MMU-9013425", "R-SPO-9013420", "R-RNO-8985586", "R-RNO-9013106", "R-HSA-9013420", "R-HSA-399719", "R-RNO-390522", "R-HSA-445355", "R-SPO-9013419", "R-DRE-9013424", "R-SPO-9013425", "R-HSA-9662361", "R-HSA-9927432", "R-MMU-9013424", "R-RNO-5250924", "R-DME-350480", "R-MMU-8985586", "R-DME-9013422", "R-MMU-2029482", "R-DME-9013418", "R-HSA-9824585", "R-HSA-9703465", "R-HSA-8985586", "R-HSA-3928663", "R-HSA-5627123", "R-MMU-9013026", "R-HSA-390522", "R-SCE-9013419", "R-HSA-5250924", "R-RNO-432040", "R-HSA-9013419", "R-HSA-9664422", "R-SCE-190873", "R-MMU-399719", "R-DME-9013420", "R-HSA-5627117", "R-HSA-2453902"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-DME-190873:r:Gap junction degradation", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-264876:r:Insulin processing", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013424:r:RHOV GTPase cycle", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013420:r:RHOU GTPase cycle", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-9013419:r:RHOT2 GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-390522:r:Striated Muscle Contraction", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-GGA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-SPO-190873:r:Gap junction degradation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-9013026:r:RHOB GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-190873:r:Gap junction degradation", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-190873:r:Gap junction degradation", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-DRE-9013424:r:RHOV GTPase cycle", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-390522:r:Striated Muscle Contraction", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SCE-190873:r:Gap junction degradation", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-DME-9013420:r:RHOU GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Domain"}, "IPR001610": {"description": "PAC motif", "go_ids": [], "go_terms": [], "name": "PAC", "pathway_ids": ["R-HSA-1989781", "R-HSA-211981", "R-MMU-1234174", "R-DRE-211976", "R-CFA-5576890", "R-HSA-1234158", "R-HSA-8951664", "R-HSA-5689880", "R-DME-8951664", "R-RNO-211981", "R-HSA-1368108", "R-SSC-1296072", "R-MMU-8951664", "R-MMU-1234158", "R-MMU-5689880", "R-RNO-8857538", "R-HSA-9701898", "R-HSA-2122947", "R-DRE-211981", "R-HSA-1234176", "R-RNO-8937144", "R-DME-432524", "R-RNO-1234174", "R-HSA-9931521", "R-HSA-452723", "R-HSA-6785807", "R-MMU-1234176", "R-RNO-5689880", "R-RNO-211945", "R-DME-432620", "R-DME-432408", "R-MMU-211976", "R-MMU-9768919", "R-RNO-8951664", "R-RNO-211976", "R-DME-1234176", "R-HSA-9931529", "R-HSA-211976", "R-MMU-211945", "R-HSA-8857538", "R-HSA-9768919", "R-RNO-5576890", "R-HSA-5576890", "R-MMU-5576890", "R-RNO-1234176", "R-HSA-9664873", "R-DRE-9768919", "R-BTA-1296072", "R-HSA-211945", "R-HSA-1234174", "R-MMU-8937144", "R-DME-1234158", "R-DME-432560", "R-MMU-211981", "R-HSA-8849473", "R-HSA-9931509", "R-HSA-8937144", "R-MMU-1296072", "R-DRE-8937144", "R-RNO-9768919", "R-CFA-1296072", "R-HSA-9707616", "R-SSC-5576890", "R-DME-432626", "R-RNO-1296072", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-9909649", "R-DME-432395", "R-RNO-1234158", "R-HSA-1296072", "R-DRE-211945", "R-HSA-3214847", "R-MMU-8857538", "R-DME-432501"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-211981:r:Xenobiotics", "R-MMU-1234174:r:Cellular response to hypoxia", "R-DRE-211976:r:Endogenous sterols", "R-CFA-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-8951664:r:Neddylation", "R-RNO-211981:r:Xenobiotics", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-SSC-1296072:r:Voltage gated Potassium channels", "R-MMU-8951664:r:Neddylation", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-DRE-211981:r:Xenobiotics", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-8937144:r:Aryl hydrocarbon receptor signalling", "R-DME-432524:r:Degradation of PER", "R-RNO-1234174:r:Cellular response to hypoxia", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-DME-432620:r:Dephosphorylation of PER", "R-DME-432408:r:Transcription regulation of cwo gene", "R-MMU-211976:r:Endogenous sterols", "R-MMU-9768919:r:NPAS4 regulates expression of target genes", "R-RNO-8951664:r:Neddylation", "R-RNO-211976:r:Endogenous sterols", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9931529:r:Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK", "R-HSA-211976:r:Endogenous sterols", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-RNO-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9664873:r:Pexophagy", "R-DRE-9768919:r:NPAS4 regulates expression of target genes", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-HSA-1234174:r:Cellular response to hypoxia", "R-MMU-8937144:r:Aryl hydrocarbon receptor signalling", "R-DME-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-DME-432560:r:Transcription activation by CLK:CYC and repression by VRI", "R-MMU-211981:r:Xenobiotics", "R-HSA-8849473:r:PTK6 Expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling", "R-MMU-1296072:r:Voltage gated Potassium channels", "R-DRE-8937144:r:Aryl hydrocarbon receptor signalling", "R-RNO-9768919:r:NPAS4 regulates expression of target genes", "R-CFA-1296072:r:Voltage gated Potassium channels", "R-HSA-9707616:r:Heme signaling", "R-SSC-5576890:r:Phase 3 - rapid repolarisation", "R-DME-432626:r:Circadian Clock pathway", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", 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"R-MMU-5223345", "R-RNO-9603381", "R-HSA-877300", "R-CFA-444821", "R-MMU-6807004", "R-HSA-5663220", "R-HSA-140534", "R-HSA-5682910", "R-DDI-9013404", "R-MMU-9013149", "R-BTA-5223345", "R-GGA-433822", "R-HSA-6804115", "R-MMU-844455", "R-HSA-380284", "R-RNO-9013149", "R-MMU-9013404", "R-HSA-9013424", "R-HSA-8854518", "R-HSA-9926550", "R-HSA-9707564", "R-RNO-9026527", "R-HSA-9665247", "R-HSA-9664565", "R-MMU-140534", "R-HSA-9665244", "R-RNO-375281", "R-MMU-450520", "R-HSA-2219530", "R-MMU-2022854", "R-GGA-6798695", "R-HSA-9013404", "R-HSA-75892", "R-SPO-9652282", "R-HSA-9673221", "R-HSA-9620244", "R-HSA-5603041", "R-MMU-9793242", "R-RNO-983168", "R-RNO-8849932", "R-HSA-198203", "R-HSA-5617472", "R-HSA-445989", "R-BTA-8951664", "R-HSA-8873719", "R-RNO-9696270", "R-DME-159236", "R-MMU-9010553", "R-XTR-380270", "R-HSA-936440", "R-MMU-4615885", "R-RNO-6804115", "R-XTR-5620912", "R-BTA-114608", "R-HSA-76009", "R-GGA-6811558", "R-SPO-983168", "R-RNO-170984", "R-BTA-168638", "R-HSA-9918481", "R-DDI-171007", "R-BTA-5689896", "R-HSA-428542", "R-HSA-9679191", "R-HSA-9032500", "R-MMU-8985586", "R-MMU-844456", "R-DDI-5621575", "R-HSA-1810476", "R-DDI-983168", "R-HSA-8985586", "R-HSA-428543", "R-DME-159230", "R-MMU-9013026", "R-DDI-168638", "R-MMU-983168", "R-BTA-2022923", "R-BTA-159236", "R-MMU-9696270", "R-DRE-6804115", "R-BTA-2022857", "R-MMU-9026527", "R-HSA-975163", "R-RNO-9758274", "R-MMU-6811558", "R-HSA-140837", "R-DME-72163", "R-RNO-187042", "R-SSC-109704", "R-MMU-68877", "R-RNO-4641263", "R-HSA-8863795", "R-MMU-9707616", "R-HSA-9846298", "R-DME-214869", "R-HSA-450302", "R-HSA-5223345", "R-HSA-170984", "R-HSA-168138", "R-RNO-5682910", "R-MMU-3270619", "R-SPO-159236", "R-GGA-5686938", "R-RNO-975163", "R-MMU-5673000", "R-HSA-9758274", "R-DRE-380320", "R-DRE-450520", "R-GGA-2022857", "R-HSA-418555", "R-RNO-438066", "R-DRE-5673000", "R-RNO-2022857", "R-HSA-9820960", "R-HSA-163125", "R-HSA-166020", "R-DME-214874", "R-HSA-8955332", "R-DDI-5674135", "R-HSA-3656225", "R-RNO-936440", "R-MMU-216083", "R-RNO-388844", "R-MMU-170984", "R-MMU-9696264", "R-HSA-168164", "R-RNO-216083", "R-MMU-450302", "R-RNO-1257604", "R-MMU-166166", "R-HSA-8849932", "R-DRE-983168", "R-DRE-917937", "R-RNO-159236", "R-SPO-6803207", "R-RNO-2022870", "R-DME-376176", "R-MMU-159231", "R-MMU-936964", "R-BTA-450520", "R-HSA-9665249", "R-HSA-9770562", "R-HSA-4641263", "R-MMU-1227986", "R-HSA-109704", "R-XTR-5654687", "R-HSA-9707616", "R-HSA-9034864", "R-MMU-1257604", "R-BTA-8849932", "R-HSA-6807004", "R-RNO-159227", "R-HSA-168142", "R-BTA-844456", "R-DDI-5675221", "R-RNO-9824878", "R-DME-209968", "R-RNO-9032759", "R-RNO-159231", "R-CEL-8941413", "R-HSA-170968", "R-HSA-428540", "R-RNO-2022854", "R-HSA-5602498", "R-RNO-166016", "R-MMU-168138", "R-BTA-216083", "R-MMU-937041", "R-HSA-3595174", "R-SCE-9615933", "R-MMU-9013106", "R-HSA-5689896", "R-HSA-9828211", "R-HSA-166016", "R-MMU-5689901", "R-HSA-9026519", "R-MMU-2565942", "R-HSA-936964", "R-HSA-450321", "R-DDI-170968", "R-BTA-2022870", "R-RNO-170968", "R-CFA-2024101", "R-RNO-140534", "R-DDI-9013423", "R-HSA-168176", "R-RNO-5673001", "R-MMU-2022923", "R-RNO-3000178", "R-DRE-9696270", "R-HSA-166058", "R-MMU-5620916", "R-MMU-141444", "R-GGA-216083", "R-HSA-9034793", "R-HSA-450520", "R-MMU-159236", "R-SPO-8980692", "R-SPO-9770562", "R-HSA-4608870", "R-CFA-1474228", "R-MMU-9013406", "R-MMU-6798695", "R-HSA-975110", "R-RNO-6794361", "R-BTA-5673000", "R-MMU-9034013", "R-HSA-9013957", "R-MMU-114608", "R-HSA-167044", "R-HSA-5602571", "R-SPO-159231", "R-DDI-1660499", "R-DME-159231", "R-BTA-3000178", "R-RNO-450520", "R-GGA-2022854", "R-HSA-5602410", "R-DME-9013406", "R-MMU-168181", "R-HSA-9617324", "R-BTA-2024101", "R-RNO-166020", "R-BTA-159230", "R-HSA-2500257", "R-HSA-9013973", "R-HSA-9665246", "R-DDI-1660516", "R-HSA-1227986", "R-XTR-380284", "R-CFA-109704", "R-SCE-9793242", "R-HSA-8876493", "R-DRE-9013148", "R-HSA-438066", "R-HSA-9793242", "R-BTA-159231", "R-HSA-380259", "R-DDI-1169092", "R-DME-209442", "R-HSA-9013409", "R-HSA-2243919", "R-HSA-3000178", "R-HSA-3560783", "R-RNO-1474228", "R-HSA-9918485", "R-MMU-9013408", "R-RNO-5689901", "R-HSA-442982", "R-BTA-450321", "R-HSA-5673000", "R-DDI-5213460", "R-DDI-5673000", "R-GGA-517856", "R-HSA-5602415", "R-MMU-5620912", "R-MMU-5673001", "R-HSA-844455", "R-BTA-5689901", "R-RNO-5673000", "R-HSA-9026527", "R-RNO-2562578", "R-MMU-72163", "R-HSA-429947", "R-HSA-9660826", "R-HSA-141444", "R-DDI-5223345", "R-MMU-450321", "R-HSA-5602680", "R-HSA-9696264", "R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-BTA-917937", "R-RNO-9696264", "R-MMU-2024101", "R-HSA-9820841", "R-HSA-9013026", "R-HSA-8857538", "R-HSA-1839117", "R-HSA-2467813", "R-HSA-168928", "R-HSA-9845620", "R-MMU-430116", "R-MMU-8980692", "R-HSA-9824878", "R-HSA-9013106", "R-CEL-983168", "R-MMU-388844", "R-HSA-159227", "R-HSA-9013423", "R-GGA-451514", "R-DRE-2022857", "R-CEL-9010553", "R-MMU-917937", "R-DRE-9696264", "R-CEL-2243919", "R-MMU-6803207", "R-RNO-9707616", "R-DDI-1632852", "R-MMU-977606", "R-MMU-109704", "R-MMU-9028731", "R-DDI-392517", "R-HSA-376176", "R-HSA-5602566", "R-HSA-380270", "R-HSA-9665250", "R-HSA-9726842", "R-CEL-9615933", "R-HSA-5603037", "R-DME-8941413", "R-HSA-187024", "R-HSA-9634285", "R-DME-6803207", "R-SPO-199418", "R-MMU-2562578", "R-HSA-446388", "R-SPO-72163", "R-XTR-8854518", "R-HSA-8875360", "R-BTA-983168", "R-DDI-354192", "R-MMU-163125", "R-HSA-1606341", "R-HSA-187042", "R-HSA-430116", "R-DRE-8951664", "R-MMU-446388", "R-RNO-5223345", "R-MMU-2243919", "R-SPO-9013106", "R-HSA-380320", "R-HSA-159230", "R-RNO-159230", "R-MMU-3000178", "R-HSA-177929", "R-MMU-975163", "R-RNO-9034013", "R-DDI-1660517", "R-GGA-193634", "R-HSA-1461957", "R-MMU-193634", "R-DME-438066", "R-HSA-381426", "R-HSA-5655302", "R-DDI-193648", "R-RNO-199418", "R-HSA-2024101", "R-HSA-9665686", "R-MMU-166016", "R-MMU-8849932", "R-MMU-438066", "R-MMU-140837", "R-MMU-1461957", "R-HSA-8950505", "R-HSA-9648025", "R-DME-388844", "R-CEL-9793242", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-3656243", "R-HSA-4420332", "R-HSA-3134975", "R-MMU-199418", "R-GGA-5654687", "R-RNO-9028731", "R-MMU-6804115", "R-HSA-5689901", "R-MMU-2022870", "R-RNO-430116", "R-HSA-168188", "R-HSA-975138", "R-HSA-9034015", "R-DDI-9013149", "R-HSA-9665245", "R-HSA-9032759", "R-MMU-444821", "R-RNO-166166", "R-DDI-381676", "R-HSA-168181", "R-CFA-1971475", "R-RNO-5654687", "R-HSA-9833110", "R-MMU-9648025", "R-HSA-937072", "R-HSA-5620912", "R-HSA-9028731", "R-HSA-390471", "R-MMU-6794361", "R-HSA-444821", "R-HSA-1679131", "R-HSA-9830674", "R-DME-5223345", "R-RNO-8873719", "R-CFA-1679131", "R-BTA-450302", "R-MMU-177504", "R-XTR-2565942", "R-MMU-936440", "R-MMU-9758274", "R-MMU-1971475", "R-MMU-8857538"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-5223345:r:Miscellaneous transport and binding events", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-8951664:r:Neddylation", "R-HSA-198745:r:Signalling to STAT3", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CEL-9770562:r:mRNA Polyadenylation", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-2022870:r:CS-GAG biosynthesis", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-844455:r:The NLRP1 inflammasome", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-5689880:r:Ub-specific processing proteases", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-CEL-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-444821:r:Relaxin receptors", "R-MMU-418555:r:G alpha (s) signalling events", "R-CEL-8951664:r:Neddylation", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-DDI-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-BTA-5682910:r:LGI-ADAM interactions", "R-MMU-166020:r:Transfer of LPS from LBP carrier to CD14", "R-DDI-8951664:r:Neddylation", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-MMU-8951664:r:Neddylation", "R-RNO-198203:r:PI3K/AKT activation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-187042:r:TRKA activation by NGF", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DME-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-GGA-1461957:r:Beta defensins", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-CFA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-844456:r:The NLRP3 inflammasome", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-CEL-5223345:r:Miscellaneous transport and binding events", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-CFA-2022923:r:DS-GAG biosynthesis", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-844456:r:The NLRP3 inflammasome", "R-CEL-209968:r:Thyroxine biosynthesis", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-2024101:r:CS/DS degradation", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-216083:r:Integrin cell surface interactions", "R-DDI-3295583:r:TRP channels", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-MMU-177929:r:Signaling by EGFR", "R-HSA-9020702:r:Interleukin-1 signaling", "R-SSC-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-HSA-167021:r:PLC-gamma1 signalling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-CEL-5673000:r:RAF activation", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DRE-2022854:r:Keratan sulfate biosynthesis", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-RNO-8951664:r:Neddylation", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-HSA-1236974:r:ER-Phagosome pathway", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-DDI-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-9824856:r:Defective regulation of TLR7 by endogenous ligand", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-877300:r:Interferon gamma signaling", "R-CFA-444821:r:Relaxin receptors", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-5682910:r:LGI-ADAM interactions", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-5223345:r:Miscellaneous transport and binding events", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-844455:r:The NLRP1 inflammasome", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-RNO-375281:r:Hormone ligand-binding receptors", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9673221:r:Defective F9 activation", "R-HSA-9620244:r:Long-term potentiation", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-MMU-9793242:r:SUMOylation of nuclear envelope proteins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-8951664:r:Neddylation", "R-HSA-8873719:r:RAB geranylgeranylation", "R-RNO-9696270:r:RND2 GTPase cycle", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-170984:r:ARMS-mediated activation", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-171007:r:p38MAPK events", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-844456:r:The NLRP3 inflammasome", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-2022857:r:Keratan sulfate degradation", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-187042:r:TRKA activation by NGF", "R-SSC-109704:r:PI3K Cascade", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9707616:r:Heme signaling", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-HSA-170984:r:ARMS-mediated activation", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-5682910:r:LGI-ADAM interactions", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-GGA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-5673000:r:RAF activation", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DRE-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-GGA-2022857:r:Keratan sulfate degradation", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DRE-5673000:r:RAF activation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-166020:r:Transfer of LPS from LBP carrier to CD14", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-170984:r:ARMS-mediated activation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-RNO-216083:r:Integrin cell surface interactions", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-917937:r:Iron uptake and transport", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-DME-376176:r:Signaling by ROBO receptors", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-109704:r:PI3K Cascade", "R-XTR-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-9707616:r:Heme signaling", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-6807004:r:Negative regulation of MET activity", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-BTA-844456:r:The NLRP3 inflammasome", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-DME-209968:r:Thyroxine biosynthesis", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-BTA-216083:r:Integrin cell surface interactions", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-5689901:r:Metalloprotease DUBs", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DDI-170968:r:Frs2-mediated activation", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-RNO-170968:r:Frs2-mediated activation", "R-CFA-2024101:r:CS/DS degradation", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-RNO-3000178:r:ECM proteoglycans", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-GGA-216083:r:Integrin cell surface interactions", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-RNO-6794361:r:Neurexins and neuroligins", "R-BTA-5673000:r:RAF activation", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-MMU-114608:r:Platelet degranulation", "R-HSA-167044:r:Signalling to RAS", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-3000178:r:ECM proteoglycans", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-GGA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5602410:r:TLR3 deficiency - HSE", "R-DME-9013406:r:RHOQ GTPase cycle", "R-MMU-168181:r:Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-166020:r:Transfer of LPS from LBP carrier to CD14", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1227986:r:Signaling by ERBB2", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CFA-109704:r:PI3K Cascade", "R-SCE-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9793242:r:SUMOylation of nuclear envelope proteins", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-1169092:r:Activation of RAS in B cells", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-5689901:r:Metalloprotease DUBs", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-5673000:r:RAF activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-DDI-5673000:r:RAF activation", "R-GGA-517856:r:TLR2 subfamily cascade", "R-HSA-5602415:r:UNC93B1 deficiency - HSE", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-844455:r:The NLRP1 inflammasome", "R-BTA-5689901:r:Metalloprotease DUBs", "R-RNO-5673000:r:RAF activation", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-5223345:r:Miscellaneous transport and binding events", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-917937:r:Iron uptake and transport", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-GGA-451514:r:MyD88:TIRAP-dependent cascade initiated on plasma membrane", "R-DRE-2022857:r:Keratan sulfate degradation", "R-CEL-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-917937:r:Iron uptake and transport", "R-DRE-9696264:r:RND3 GTPase cycle", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-9707616:r:Heme signaling", "R-DDI-1632852:r:Macroautophagy", "R-MMU-977606:r:Regulation of Complement cascade", "R-MMU-109704:r:PI3K Cascade", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DDI-392517:r:Rap1 signalling", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-5602566:r:TICAM1 deficiency - HSE", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-354192:r:Integrin signaling", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-187042:r:TRKA activation by NGF", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-DRE-8951664:r:Neddylation", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-GGA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-1461957:r:Beta defensins", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-DDI-193648:r:NRAGE signals death through JNK", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-1461957:r:Beta defensins", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-CEL-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-GGA-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-5689901:r:Metalloprotease DUBs", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-HSA-168188:r:Toll Like Receptor TLR6:TLR2 Cascade", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-MMU-444821:r:Relaxin receptors", "R-RNO-166166:r:MyD88-independent TLR4 cascade", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-168181:r:Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-CFA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-444821:r:Relaxin receptors", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-5223345:r:Miscellaneous transport and binding events", "R-RNO-8873719:r:RAB geranylgeranylation", "R-CFA-1679131:r:Trafficking and processing of endosomal TLR", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Repeat"}, "IPR001612": {"description": "Caveolin", "go_ids": ["GO:0070836"], "go_terms": ["GO:0070836:caveola assembly:P"], "name": "Caveolin", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9013405", "R-CEL-8980692", "R-MMU-210991", "R-BTA-9696273", "R-MMU-9013106", "R-MMU-9013408", "R-RNO-9009391", "R-RNO-9013149", "R-MMU-9009391", "R-MMU-9013404", "R-HSA-9617828", "R-RNO-5218920", "R-BTA-9035034", "R-HSA-203615", "R-CEL-9035034", "R-SSC-9009391", "R-HSA-209968", "R-CEL-9013407", "R-HSA-5218920", "R-CFA-9013408", "R-RNO-9013408", "R-RNO-9013404", "R-RNO-9013406", "R-HSA-9013408", "R-CFA-4641262", "R-CEL-9013148", "R-HSA-203641", "R-HSA-210991", "R-BTA-9013407", "R-MMU-9035034", "R-BTA-203615", "R-CFA-9013406", "R-CFA-9013148", "R-MMU-9013407", "R-CFA-8980692", "R-RNO-9013407", "R-RNO-9013148", "R-RNO-9696273", "R-CFA-9013407", "R-RNO-203615", "R-HSA-9696264", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-CFA-9013106", "R-MMU-9013406", "R-MMU-4641262", "R-RNO-9696264", "R-MMU-209968", "R-BTA-8980692", "R-BTA-203641", "R-BTA-4641262", "R-MMU-9696264", "R-HSA-9013026", "R-CFA-203641", "R-BTA-9013106", "R-HSA-9013407", "R-CEL-209968", "R-RNO-4641262", "R-RNO-9035034", "R-MMU-8980692", "R-HSA-9735871", "R-RNO-8980692", "R-RNO-9696270", "R-BTA-9013406", "R-CFA-9035034", "R-HSA-9013106", "R-MMU-203615", "R-CFA-9013404", "R-MMU-9013148", "R-BTA-9013148", "R-MMU-203641", "R-CFA-9013149", "R-CEL-9013149", "R-BTA-9013423", "R-HSA-9013423", "R-CFA-9696264", "R-HSA-9035034", "R-HSA-9013148", "R-HSA-4641262", "R-CEL-9013406", "R-RNO-203641", "R-RNO-9013106", "R-CFA-9696270", "R-CEL-9013423", "R-RNO-209968", "R-BTA-9696270", "R-CEL-210991", "R-RNO-210991", "R-HSA-445355", "R-HSA-9696270", "R-MMU-5218920", "R-BTA-209968", "R-CFA-9009391", "R-BTA-5218920", "R-BTA-9009391", "R-HSA-163560", "R-CFA-9696273", "R-RNO-9013423", "R-HSA-9755779", "R-CFA-209968", "R-BTA-9013408", "R-HSA-9009391", "R-BTA-9013404", "R-BTA-9696264", "R-MMU-9013026", "R-MMU-9696270", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9013149", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-210991:r:Basigin interactions", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-203615:r:eNOS activation", "R-CEL-9035034:r:RHOF GTPase cycle", "R-SSC-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-209968:r:Thyroxine biosynthesis", "R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-CFA-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CFA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-210991:r:Basigin interactions", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-BTA-203615:r:eNOS activation", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CFA-8980692:r:RHOA GTPase cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-CFA-9013407:r:RHOH GTPase cycle", "R-RNO-203615:r:eNOS activation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-209968:r:Thyroxine biosynthesis", "R-BTA-8980692:r:RHOA GTPase cycle", "R-BTA-203641:r:NOSTRIN mediated eNOS trafficking", "R-BTA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-CFA-203641:r:NOSTRIN mediated eNOS trafficking", "R-BTA-9013106:r:RHOC GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle", "R-CEL-209968:r:Thyroxine biosynthesis", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-CFA-9035034:r:RHOF GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-203615:r:eNOS activation", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CFA-9696264:r:RND3 GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-9013106:r:RHOC GTPase cycle", "R-CFA-9696270:r:RND2 GTPase cycle", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-RNO-209968:r:Thyroxine biosynthesis", "R-BTA-9696270:r:RND2 GTPase cycle", "R-CEL-210991:r:Basigin interactions", "R-RNO-210991:r:Basigin interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-209968:r:Thyroxine biosynthesis", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-163560:r:Triglyceride catabolism", "R-CFA-9696273:r:RND1 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-CFA-209968:r:Thyroxine biosynthesis", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-BTA-9696264:r:RND3 GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Family"}, "IPR001613": {"description": "Flavin amine oxidase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Flavin_amine_oxidase", "pathway_ids": ["R-DDI-379398", "R-DDI-380612", "R-MMU-181430", "R-DRE-181430", "R-DDI-379401", "R-HSA-141333", "R-RNO-379398", "R-RNO-379397", "R-DRE-141333", "R-MMU-141333", "R-HSA-5579012", "R-MMU-380612", "R-RNO-380612", "R-RNO-141333", "R-BTA-380612", "R-BTA-181430", "R-HSA-181430", "R-MMU-379401", "R-RNO-379401", "R-MMU-379397", "R-RNO-181430", "R-HSA-8964208", "R-MMU-379398", "R-HSA-379397", "R-DRE-379401", "R-HSA-6785807", "R-HSA-379398", "R-MMU-8964208", "R-DDI-141333", "R-BTA-379398", "R-BTA-141333", "R-BTA-379401", "R-BTA-379397", "R-HSA-379401", "R-DRE-379398", "R-DDI-181430", "R-DDI-379397", "R-DRE-380612", "R-HSA-380612", "R-DRE-379397"], "pathways": ["R-DDI-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-DDI-380612:r:Metabolism of serotonin", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DRE-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DDI-379401:r:Dopamine clearance from the synaptic cleft", "R-HSA-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-RNO-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-RNO-379397:r:Enzymatic degradation of dopamine by COMT", "R-DRE-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-MMU-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-HSA-5579012:r:Defective MAOA causes BRUNS", "R-MMU-380612:r:Metabolism of serotonin", "R-RNO-380612:r:Metabolism of serotonin", "R-RNO-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-BTA-380612:r:Metabolism of serotonin", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-379401:r:Dopamine clearance from the synaptic cleft", "R-RNO-379401:r:Dopamine clearance from the synaptic cleft", "R-MMU-379397:r:Enzymatic degradation of dopamine by COMT", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-8964208:r:Phenylalanine metabolism", "R-MMU-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-HSA-379397:r:Enzymatic degradation of dopamine by COMT", "R-DRE-379401:r:Dopamine clearance from the synaptic cleft", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-MMU-8964208:r:Phenylalanine metabolism", "R-DDI-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-BTA-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-BTA-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-BTA-379401:r:Dopamine clearance from the synaptic cleft", "R-BTA-379397:r:Enzymatic degradation of dopamine by COMT", "R-HSA-379401:r:Dopamine clearance from the synaptic cleft", "R-DRE-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-DDI-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DDI-379397:r:Enzymatic degradation of dopamine by COMT", "R-DRE-380612:r:Metabolism of serotonin", "R-HSA-380612:r:Metabolism of serotonin", "R-DRE-379397:r:Enzymatic degradation of dopamine by COMT"], "type": "Family"}, "IPR001614": {"description": "Myelin proteolipid protein PLP", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Myelin_PLP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001615": {"description": "Delta-endotoxin CytB", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Endotoxin_CytB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001619": {"description": "Sec1-like protein", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "Sec1-like", "pathway_ids": ["R-MMU-204005", "R-DDI-114516", "R-MMU-6811438", "R-CEL-181430", "R-MMU-181430", "R-CEL-114516", "R-SCE-204005", "R-SCE-114608", "R-DDI-114608", "R-CEL-888590", "R-RNO-212676", "R-SCE-8980692", "R-RNO-983231", "R-CEL-264642", "R-HSA-210500", "R-MMU-449836", "R-BTA-181430", "R-HSA-181430", "R-DDI-204005", "R-DME-210500", "R-DME-8980692", "R-DME-114608", "R-RNO-6811438", "R-HSA-983231", "R-CEL-114608", "R-HSA-264642", "R-BTA-888590", "R-CEL-212676", "R-DDI-6811438", "R-MMU-264642", "R-SPO-8980692", "R-HSA-204005", "R-HSA-8980692", "R-DME-181430", "R-RNO-264642", "R-HSA-1445148", "R-RNO-181429", "R-SCE-983231", "R-HSA-212676", "R-MMU-114608", "R-DME-204005", "R-HSA-114516", "R-HSA-449836", "R-BTA-210500", "R-HSA-6811438", "R-MMU-8980692", "R-RNO-8980692", "R-CEL-210500", "R-MMU-983231", "R-DME-264642", "R-SPO-114608", "R-HSA-6794361", "R-RNO-114608", "R-DME-888590", "R-DME-449836", "R-HSA-181429", "R-SPO-114516", "R-HSA-114608", "R-HSA-9754560", "R-HSA-9636383", "R-BTA-212676", "R-CEL-181429", "R-DME-181429", "R-BTA-264642", "R-DDI-449836", "R-MMU-212676", "R-MMU-114516", "R-SCE-114516", "R-MMU-888590", "R-RNO-210500", "R-RNO-181430", "R-MMU-210500", "R-SPO-204005", "R-MMU-181429", "R-CEL-449836", "R-DME-212676", "R-RNO-204005", "R-HSA-888590", "R-DME-114516", "R-BTA-181429", "R-RNO-888590", "R-RNO-449836", "R-HSA-422356"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-MMU-6811438:r:Intra-Golgi traffic", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-114608:r:Platelet degranulation", "R-DDI-114608:r:Platelet degranulation", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-449836:r:Other interleukin signaling", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-114608:r:Platelet degranulation", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-114608:r:Platelet degranulation", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DDI-6811438:r:Intra-Golgi traffic", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-114608:r:Platelet degranulation", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-HSA-449836:r:Other interleukin signaling", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SPO-114608:r:Platelet degranulation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-114608:r:Platelet degranulation", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-449836:r:Other interleukin signaling", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DDI-449836:r:Other interleukin signaling", 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insulin secretion"], "type": "Family"}, "IPR001621": {"description": "Fungal ligninase", "go_ids": ["GO:0004601", "GO:0006979", "GO:0020037"], "go_terms": ["GO:0004601:peroxidase activity:F", "GO:0006979:response to oxidative stress:P", "GO:0020037:heme binding:F"], "name": "Ligninase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001623": {"description": "DnaJ domain", "go_ids": [], "go_terms": [], "name": "DnaJ_domain", "pathway_ids": ["R-SCE-3371453", "R-HSA-6798695", "R-MMU-8856828", "R-HSA-9833482", "R-BTA-3371568", "R-HSA-8856828", "R-SPO-3371571", "R-MMU-9770562", "R-HSA-9918487", "R-SCE-9841251", "R-BTA-6798695", "R-RNO-425561", "R-MMU-8957275", "R-MMU-9833482", "R-HSA-3371453", "R-HSA-9662360", "R-HSA-1268020", "R-MMU-381426", "R-SCE-1268020", "R-HSA-381426", "R-RNO-432722", "R-DDI-6798695", "R-BTA-3371453", "R-HSA-432720", "R-HSA-9918432", "R-BTA-5687128", "R-HSA-425561", "R-MMU-5578775", "R-BTA-3371571", "R-BTA-888590", "R-SCE-9865881", "R-DRE-3371453", "R-HSA-8949613", "R-MMU-425561", "R-RNO-381426", "R-HSA-72163", "R-MMU-3371568", "R-MMU-5358493", "R-MMU-9841251", "R-SPO-9841251", "R-MMU-6798695", "R-BTA-3371497", "R-MMU-5687128", "R-MMU-3371497", "R-RNO-6798695", "R-SCE-3371497", "R-SPO-3371453", "R-RNO-3371453", "R-MMU-432722", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-RNO-9841251", "R-SCE-3371568", "R-HSA-192823", "R-DME-888590", "R-MMU-418359", "R-RNO-8957275", "R-HSA-5578775", "R-RNO-8856828", "R-MMU-432720", "R-HSA-432722", "R-HSA-9918481", "R-HSA-3371568", "R-SCE-3371571", "R-MMU-3371453", "R-HSA-418359", "R-DDI-9833482", "R-HSA-381038", "R-HSA-9770562", "R-SPO-3371568", "R-SCE-1362409", "R-DDI-3371453", "R-DME-6798695", "R-MMU-888590", "R-RNO-5578775", "R-HSA-9841251", "R-RNO-418359", "R-XTR-3371453", "R-MMU-3371571", "R-SPO-3371497", "R-HSA-888590", "R-HSA-5687128", "R-DDI-3371497", "R-RNO-9770562", "R-HSA-3371571", "R-HSA-5358493", "R-HSA-8957275", "R-BTA-9841251", "R-RNO-888590", "R-RNO-9833482"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9833482:r:PKR-mediated signaling", "R-BTA-3371568:r:Attenuation phase", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-425561:r:Sodium/Calcium exchangers", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SCE-1268020:r:Mitochondrial protein import", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-425561:r:Sodium/Calcium exchangers", "R-MMU-5578775:r:Ion homeostasis", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-SCE-9865881:r:Complex III assembly", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-8949613:r:Cristae formation", "R-MMU-425561:r:Sodium/Calcium exchangers", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-3371568:r:Attenuation phase", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-6798695:r:Neutrophil degranulation", "R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-6798695:r:Neutrophil 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"R-DDI-9833482:r:PKR-mediated signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SPO-3371568:r:Attenuation phase", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DDI-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-9833482:r:PKR-mediated signaling"], "type": "Domain"}, "IPR001624": {"description": "Flagellar hook-basal body complex protein FliE", "go_ids": ["GO:0003774", "GO:0005198", "GO:0009288", "GO:0071973"], "go_terms": ["GO:0003774:cytoskeletal motor activity:F", "GO:0005198:structural molecule activity:F", "GO:0009288:bacterial-type flagellum:C", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "FliE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001626": {"description": "ABC transporter, TroCD-like", "go_ids": ["GO:0005886", "GO:0043190", "GO:0055085"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0043190:ATP-binding cassette (ABC) transporter complex:C", "GO:0055085:transmembrane transport:P"], "name": "ABC_TroCD", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR001627": {"description": "Sema domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Semap_dom", "pathway_ids": ["R-HSA-9013405", "R-HSA-8874081", "R-HSA-8875555", "R-DRE-399954", "R-MMU-6811558", "R-MMU-8875791", "R-CEL-416482", "R-RNO-416550", "R-MMU-416572", "R-MMU-8865999", "R-SSC-6811558", "R-HSA-6806942", "R-RNO-399954", "R-MMU-8851805", "R-RNO-6811558", "R-MMU-399954", "R-HSA-399955", "R-HSA-8875513", "R-DRE-416550", "R-HSA-9825892", "R-RNO-8865999", "R-MMU-5673001", "R-RNO-5673001", "R-RNO-6806942", "R-DRE-416572", "R-MMU-399955", "R-HSA-416482", "R-HSA-2219530", "R-SSC-416550", "R-HSA-9696264", "R-HSA-5673001", "R-HSA-6811558", "R-MMU-8875555", "R-RNO-5173214", "R-RNO-8875656", "R-DME-416572", "R-RNO-8851805", "R-HSA-399954", "R-DRE-399956", "R-MMU-5173214", "R-DME-416482", "R-RNO-9696264", "R-MMU-8875513", "R-DME-416700", "R-SSC-6806942", "R-RNO-8875555", "R-MMU-9696264", "R-HSA-1257604", "R-SSC-9734091", "R-MMU-399956", "R-MMU-416700", "R-HSA-8865999", "R-MMU-416550", "R-RNO-8851907", "R-SSC-1257604", "R-SSC-8875513", "R-HSA-416550", "R-HSA-399956", "R-HSA-416572", "R-RNO-1257604", "R-CEL-416700", "R-RNO-9734091", "R-RNO-8874081", "R-RNO-8875513", "R-MMU-8874081", "R-CEL-399955", "R-HSA-416700", "R-HSA-8851907", "R-SSC-8874081", "R-MMU-8852405", "R-HSA-9615017", "R-CEL-399956", "R-HSA-8851805", "R-SSC-8851907", "R-MMU-9734091", "R-HSA-9734091", "R-RNO-399956", "R-HSA-8875791", "R-HSA-8852405", "R-SSC-6807004", "R-HSA-9013508", "R-HSA-9696270", "R-RNO-416700", "R-RNO-8875791", "R-HSA-5083635", "R-SSC-8875555", "R-MMU-1257604", "R-HSA-6807004", "R-CEL-416572", "R-RNO-6807004", "R-SSC-5673001", "R-MMU-6806942", "R-RNO-399955", "R-HSA-5173214", "R-MMU-8851907", "R-MMU-8875656", "R-MMU-416482", "R-SSC-8875791", "R-HSA-9022699", "R-MMU-6807004", "R-SSC-8865999", "R-HSA-8875656", "R-SSC-8851805", "R-DME-5173214", "R-MMU-9696273", "R-MMU-9696270", "R-SSC-8875656", "R-HSA-8875360", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8875791:r:MET activates STAT3", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-8865999:r:MET activates PTPN11", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-8851805:r:MET activates RAS signaling", 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"R-SSC-8875656:r:MET receptor recycling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR001628": {"description": "Zinc finger, nuclear hormone receptor-type", "go_ids": ["GO:0003700", "GO:0006355", "GO:0008270", "GO:0043565"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0008270:zinc ion binding:F", "GO:0043565:sequence-specific DNA binding:F"], "name": "Znf_hrmn_rcpt", "pathway_ids": ["R-RNO-193807", "R-SSC-1251985", "R-DRE-211976", "R-DRE-192105", "R-SSC-3371497", "R-MMU-6811558", "R-HSA-5689880", "R-HSA-8936459", "R-RNO-9009391", "R-MMU-9009391", "R-DRE-400206", "R-RNO-9018519", "R-MMU-5689896", "R-DME-5689896", "R-SSC-9009391", "R-BTA-9018519", "R-MMU-5689880", "R-DME-198693", "R-SSC-8939211", "R-RNO-6811558", "R-HSA-9844594", "R-SSC-383280", "R-DRE-6811558", "R-BTA-6811558", "R-CEL-159418", 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"PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR001645": {"description": "Folylpolyglutamate synthetase", "go_ids": ["GO:0004326", "GO:0005524", "GO:0009396"], "go_terms": ["GO:0004326:tetrahydrofolylpolyglutamate synthase activity:F", "GO:0005524:ATP binding:F", "GO:0009396:folic acid-containing compound biosynthetic process:P"], "name": "Folylpolyglutamate_synth", "pathway_ids": ["PWY-2161", "R-SCE-196757", "R-SPO-196757", "R-DDI-196757", "R-MMU-196757", "R-HSA-196757", "R-CEL-196757"], "pathways": ["PWY-2161:t:folate 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"R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-HSA-3247509:r:Chromatin modifying enzymes", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9670615:r:Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal 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"R-HSA-3108214", "R-HSA-9725554", "R-SPO-2559580", "R-MMU-9013148", "R-HSA-8953750", "R-HSA-1660499", "R-HSA-5628897", "R-HSA-6794361", "R-DME-209214", "R-DME-2559580", "R-RNO-166166", "R-HSA-114508", "R-HSA-6802946", "R-DME-3899300", "R-HSA-5578775", "R-RNO-9013106", "R-CEL-181429", "R-CEL-1660661", "R-HSA-9938206", "R-HSA-6803211", "R-HSA-5620912", "R-MMU-1855204", "R-HSA-937072", "R-DRE-2682334", "R-DME-209190", "R-RNO-6809371", "R-HSA-9013420", "R-MMU-202433", "R-MMU-8849469", "R-CEL-6794361", "R-DDI-3295583", "R-DRE-8956319", "R-SCE-2559580", "R-MMU-6794361", "R-RNO-5578775", "R-HSA-9662361", "R-HSA-9927432", "R-MMU-2682334", "R-MMU-3928663", "R-DME-983695", "R-MMU-181429", "R-MMU-983695", "R-HSA-983168", "R-HSA-166166", "R-HSA-1660661", "R-MMU-8939243", "R-DDI-5621575", "R-PFA-5675482", "R-HSA-3928663", "R-CFA-912526", "R-CEL-5578775", "R-MMU-2871809", "R-HSA-6803204", "R-MMU-9013026", "R-MMU-3928662", "R-DDI-168638", "R-MMU-2424491", "R-MMU-983168", "R-RNO-1855204", "R-DRE-3928665", "R-HSA-9013406", "R-HSA-2892247", "R-HSA-3899300", "R-MMU-9696270", "R-PFA-5357905", "R-HSA-9696273"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-3928664:r:Ephrin signaling", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-8853659:r:RET signaling", "R-DDI-5673000:r:RAF activation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2424491:r:DAP12 signaling", "R-PFA-5689896:r:Ovarian tumor domain proteases", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-PFA-5673000:r:RAF activation", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-1483166:r:Synthesis of PA", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-HSA-202433:r:Generation of second messenger molecules", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-5620971:r:Pyroptosis", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9824272:r:Somitogenesis", "R-HSA-1483166:r:Synthesis of PA", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-373760:r:L1CAM interactions", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DRE-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3928664:r:Ephrin signaling", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-PFA-430116:r:GP1b-IX-V activation signalling", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-DME-5578775:r:Ion homeostasis", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-DDI-392517:r:Rap1 signalling", "R-DRE-6809371:r:Formation of the cornified envelope", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-PFA-5675221:r:Negative regulation of MAPK pathway", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-1660499:r:Synthesis 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"R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DDI-170968:r:Frs2-mediated activation", "R-HSA-5545619:r:XAV939 stabilizes AXIN", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-CFA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-MMU-5578775:r:Ion homeostasis", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-PFA-5213460:r:RIPK1-mediated regulated necrosis", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-4641257:r:Degradation of AXIN", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-6794361:r:Neurexins and neuroligins", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-PFA-5689880:r:Ub-specific processing proteases", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-6809371:r:Formation of the cornified envelope", "R-CEL-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-SPO-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DME-209214:r:Phosphorylation of SMO", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-166166:r:MyD88-independent TLR4 cascade", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-DME-209190:r:Phosphorylation of CI", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9013420:r:RHOU GTPase cycle", "R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-6794361:r:Neurexins and neuroligins", "R-DDI-3295583:r:TRP channels", "R-DRE-8956319:r:Nucleotide catabolism", "R-SCE-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-6794361:r:Neurexins and neuroligins", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-PFA-5675482:r:Regulation of necroptotic cell death", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-CFA-912526:r:Interleukin receptor SHC signaling", "R-CEL-5578775:r:Ion homeostasis", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-MMU-2424491:r:DAP12 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9696270:r:RND2 GTPase cycle", "R-PFA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR001661": {"description": "Glycoside hydrolase, family 37", "go_ids": ["GO:0004555", "GO:0005991"], "go_terms": ["GO:0004555:alpha,alpha-trehalase activity:F", "GO:0005991:trehalose metabolic process:P"], "name": "Glyco_hydro_37", "pathway_ids": ["R-HSA-189085"], "pathways": ["R-HSA-189085:r:Digestion of dietary carbohydrate"], "type": "Family"}, "IPR001662": {"description": "Elongation factor 1B gamma, C-terminal", "go_ids": ["GO:0003746", "GO:0006414"], "go_terms": ["GO:0003746:translation elongation factor activity:F", "GO:0006414:translational elongation:P"], "name": "EF1B_G_C", "pathway_ids": ["R-SCE-156842", "R-HSA-156842", "R-MMU-156842", "R-DME-156842", "R-HSA-9725370", "R-RNO-156842"], "pathways": ["R-SCE-156842:r:Eukaryotic Translation Elongation", "R-HSA-156842:r:Eukaryotic Translation Elongation", "R-MMU-156842:r:Eukaryotic Translation Elongation", "R-DME-156842:r:Eukaryotic Translation Elongation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-156842:r:Eukaryotic Translation Elongation"], "type": "Domain"}, "IPR001663": {"description": "Aromatic-ring-hydroxylating dioxygenase, alpha subunit", "go_ids": ["GO:0051537"], "go_terms": ["GO:0051537:2 iron, 2 sulfur cluster binding:F"], "name": "Rng_hydr_dOase-A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001665": {"description": "Norovirus peptidase C37", "go_ids": ["GO:0004197", "GO:0006508"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Norovirus_pept_C37", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR001666": {"description": "Phosphatidylinositol transfer protein", "go_ids": ["GO:0008526", "GO:0015914"], "go_terms": ["GO:0008526:phosphatidylinositol transfer activity:F", "GO:0015914:phospholipid transport:P"], "name": "PI_transfer", "pathway_ids": ["R-HSA-1483226", "R-BTA-1483196", "R-DDI-1483226", "R-MMU-1483226", "R-RNO-1483196", "R-HSA-418890", "R-HSA-8950505", "R-HSA-1483196", "R-RNO-1483226", "R-DME-1483226", "R-DDI-1483196", "R-MMU-1483196"], "pathways": ["R-HSA-1483226:r:Synthesis of PI", "R-BTA-1483196:r:PI and PC transport between ER and Golgi membranes", "R-DDI-1483226:r:Synthesis of PI", "R-MMU-1483226:r:Synthesis of PI", "R-RNO-1483196:r:PI and PC transport between ER and Golgi membranes", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-1483196:r:PI and PC transport between ER and Golgi membranes", "R-RNO-1483226:r:Synthesis of PI", "R-DME-1483226:r:Synthesis of PI", "R-DDI-1483196:r:PI and PC transport between ER and Golgi membranes", "R-MMU-1483196:r:PI and PC transport between ER and Golgi membranes"], "type": "Family"}, "IPR001667": {"description": "DDH domain", "go_ids": [], "go_terms": [], "name": "DDH_dom", "pathway_ids": ["PWY-7807", "PWY-7805"], "pathways": ["PWY-7807:t:glyphosate degradation III", "PWY-7805:t:(aminomethyl)phosphonate degradation"], "type": "Domain"}, "IPR001668": {"description": "Plasmid recombination enzyme", "go_ids": ["GO:0003677", "GO:0006310"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006310:DNA recombination:P"], "name": "Mob_Pre", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001669": {"description": "Arginine repressor", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Arg_repress", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001670": {"description": "Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA", "go_ids": ["GO:0016491", "GO:0046872"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0046872:metal ion binding:F"], "name": "ADH_Fe/GldA", "pathway_ids": ["R-CEL-880009", "R-DME-880009", "R-HSA-880009", "R-BTA-880009", "R-RNO-880009", "R-MMU-880009", "R-DDI-880009"], "pathways": ["R-CEL-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DME-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DDI-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "type": "Domain"}, "IPR001672": {"description": "Phosphoglucose isomerase (PGI)", "go_ids": ["GO:0004347", "GO:0006094", "GO:0006096"], "go_terms": ["GO:0004347:glucose-6-phosphate isomerase activity:F", "GO:0006094:gluconeogenesis:P", "GO:0006096:glycolytic process:P"], "name": "G6P_Isomerase", "pathway_ids": ["PWY-7385", "PWY-5659", "PWY-5514", "PWY-6142", "PWY-7238", "PWY-622", "PWY-621", "PWY-6992", "PWY-7347", "PWY-6981", "PWY-5384", "PWY-8013", "PWY-3801", "PWY-5054", "R-RNO-6798695", "R-HSA-6798695", "R-DDI-6798695", "R-MMU-70171", "R-SSC-6798695", "R-SPO-6798695", "R-DDI-5628897", "R-RNO-70263", "R-SCE-70171", "R-SCE-5628897", "R-SSC-70263", "R-SPO-5628897", "R-DME-6798695", "R-SSC-5628897", "R-BTA-70171", "R-SCE-6798695", "R-DME-70171", "R-RNO-5628897", "R-BTA-6798695", "R-MMU-70263", "R-DDI-70171", "R-HSA-5628897", "R-DME-70263", "R-DDI-70263", "R-BTA-5628897", "R-RNO-70171", "R-SSC-70171", "R-HSA-70263", "R-BTA-70263", "R-MMU-5628897", "R-SCE-70263", "R-MMU-6798695", "R-DME-5628897", "R-HSA-70171", "R-SPO-70171", "R-SPO-70263"], "pathways": ["PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5659:t:GDP-mannose biosynthesis", "PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-7238:t:sucrose biosynthesis II", "PWY-622:t:starch biosynthesis", "PWY-621:t:sucrose degradation III (sucrose invertase)", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7347:t:sucrose biosynthesis III", "PWY-6981:t:chitin biosynthesis", "PWY-5384:t:sucrose degradation IV (sucrose phosphorylase)", "PWY-8013:t:UDP-N-acetyl-D-galactosamine biosynthesis III", "PWY-3801:t:sucrose degradation II (sucrose synthase)", "PWY-5054:t:D-sorbitol biosynthesis I", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-70171:r:Glycolysis", "R-SSC-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-70263:r:Gluconeogenesis", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-6798695:r:Neutrophil degranulation", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-70171:r:Glycolysis", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-70171:r:Glycolysis", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-70263:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-70171:r:Glycolysis", "R-SSC-70171:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-70263:r:Gluconeogenesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Family"}, "IPR001673": {"description": "Dictyostelium repeat", "go_ids": [], "go_terms": [], "name": "Dicty_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR001674": {"description": "GMP synthase, C-terminal", "go_ids": ["GO:0003922", "GO:0005524", "GO:0006164", "GO:0006177"], "go_terms": ["GO:0003922:GMP synthase (glutamine-hydrolyzing) activity:F", "GO:0005524:ATP binding:F", "GO:0006164:purine nucleotide biosynthetic process:P", "GO:0006177:GMP biosynthetic process:P"], "name": "GMP_synth_C", "pathway_ids": ["PWY-7221", "R-MMU-9748787", "R-SPO-73817", "R-SCE-9748787", "R-DDI-73817", "R-HSA-9748787", "R-CEL-9748787", "R-DDI-9748787", "R-SCE-73817", "R-MMU-73817", "R-CEL-73817", "R-HSA-73817", "R-RNO-73817", "R-SPO-9748787", "R-PFA-73817", "R-RNO-9748787", "R-PFA-9748787"], "pathways": ["PWY-7221:t:guanosine ribonucleotides de novo biosynthesis", "R-MMU-9748787:r:Azathioprine ADME", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-9748787:r:Azathioprine ADME", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-9748787:r:Azathioprine ADME", "R-DDI-9748787:r:Azathioprine ADME", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-9748787:r:Azathioprine ADME", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-9748787:r:Azathioprine ADME", "R-PFA-9748787:r:Azathioprine ADME"], "type": "Domain"}, "IPR001675": {"description": "Glycosyl transferase family 29", "go_ids": ["GO:0008373", "GO:0009101"], "go_terms": ["GO:0008373:sialyltransferase activity:F", "GO:0009101:glycoprotein biosynthetic process:P"], "name": "Glyco_trans_29", "pathway_ids": ["R-GGA-975577", "R-HSA-9694719", "R-RNO-9037629", "R-HSA-977068", "R-HSA-9694548", "R-GGA-4085001", "R-DRE-4085001", "R-GGA-2022854", "R-RNO-977068", "R-HSA-9037629", "R-MMU-4085001", "R-GGA-977068", "R-BTA-2022854", "R-MMU-977068", "R-HSA-4085001", "R-XTR-4085001", "R-HSA-1912420", "R-BTA-4085001", "R-BTA-9037629", "R-MMU-975577", "R-MMU-2022854", "R-HSA-419037", "R-RNO-975577", "R-HSA-9840309", "R-HSA-2022854", "R-HSA-3656243", "R-RNO-9840309", "R-RNO-4085001", "R-MMU-9840309", "R-RNO-2022854", "R-HSA-975577", "R-HSA-9683673", "R-RNO-419037", "R-MMU-9037629", "R-MMU-419037"], "pathways": ["R-GGA-975577:r:N-Glycan antennae elongation", "R-HSA-9694719:r:Maturation of protein 3a", "R-RNO-9037629:r:Lewis blood group biosynthesis", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-9694548:r:Maturation of spike protein", "R-GGA-4085001:r:Sialic acid metabolism", "R-DRE-4085001:r:Sialic acid metabolism", "R-GGA-2022854:r:Keratan sulfate biosynthesis", "R-RNO-977068:r:Termination of O-glycan biosynthesis", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-MMU-4085001:r:Sialic acid metabolism", "R-GGA-977068:r:Termination of O-glycan biosynthesis", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-4085001:r:Sialic acid metabolism", "R-XTR-4085001:r:Sialic acid metabolism", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-BTA-4085001:r:Sialic acid metabolism", "R-BTA-9037629:r:Lewis blood group biosynthesis", "R-MMU-975577:r:N-Glycan antennae elongation", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-975577:r:N-Glycan antennae elongation", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-4085001:r:Sialic acid metabolism", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-975577:r:N-Glycan antennae elongation", "R-HSA-9683673:r:Maturation of protein 3a", "R-RNO-419037:r:NCAM1 interactions", "R-MMU-9037629:r:Lewis blood group biosynthesis", "R-MMU-419037:r:NCAM1 interactions"], "type": "Family"}, "IPR001676": {"description": "Picornavirus capsid", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Picornavirus_capsid", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR001677": {"description": "Transferrin-binding protein B, C-lobe/N-lobe beta-barrel domain", "go_ids": [], "go_terms": [], "name": "TbpB_B_D", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001679": {"description": "NAD-dependent DNA ligase", "go_ids": ["GO:0003911", "GO:0006260", "GO:0006281"], "go_terms": ["GO:0003911:DNA ligase (NAD+) activity:F", "GO:0006260:DNA replication:P", "GO:0006281:DNA repair:P"], "name": "DNA_ligase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001680": {"description": "WD40 repeat", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "WD40_rpt", "pathway_ids": ["R-HSA-174178", "R-SSC-9766229", "R-HSA-6807505", "R-XTR-9615933", "R-HSA-9604323", "R-HSA-8936459", "R-HSA-8951664", "R-MMU-1632852", "R-BTA-3928662", "R-MMU-6804756", "R-RNO-8953750", "R-DDI-6782210", "R-HSA-69231", "R-DDI-72163", "R-XTR-5696394", "R-SSC-159231", "R-MMU-110314", "R-MMU-5689880", "R-CFA-392851", "R-HSA-432040", 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"R-MMU-5357956", "R-MMU-174178", "R-MMU-418594", "R-DRE-9627069", "R-RNO-418594", "R-XTR-5696395", "R-DME-73776", "R-HSA-9907900", "R-BTA-381771", "R-CEL-3108214", "R-DDI-418594", "R-HSA-6782210", "R-MMU-9841922", "R-DME-111459", "R-HSA-9627069", "R-DME-9037629", "R-MMU-159231", "R-HSA-195253", "R-CEL-69273", "R-MMU-3214847", "R-XTR-191859", "R-DRE-9646399", "R-BTA-166208", "R-HSA-109704", "R-MMU-1257604", "R-BTA-674695", "R-RNO-111459", "R-DME-3301854", "R-MMU-174184", "R-HSA-75955", "R-DRE-2565942", "R-RNO-159231", "R-MMU-2485179", "R-RNO-432040", "R-BTA-9639288", "R-GGA-380284", "R-XTR-6791226", "R-DRE-3232142", "R-RNO-392170", "R-MMU-5694530", "R-DRE-4551638", "R-RNO-5357905", "R-HSA-6796648", "R-HSA-9841922", "R-MMU-381676", "R-RNO-380320", "R-MMU-72706", "R-MMU-389357", "R-RNO-111458", "R-HSA-3371453", "R-DME-3371571", "R-HSA-202040", "R-RNO-9772755", "R-HSA-9933387", "R-DRE-9013407", "R-HSA-8943724", "R-BTA-5620912", "R-SPO-176407", "R-HSA-420092", "R-HSA-1296041", "R-BTA-204005", "R-XTR-69601", "R-DME-6807878", "R-DRE-9018519", "R-DME-209413", "R-SSC-176407", "R-BTA-156827", "R-SCE-6811434", "R-BTA-2559580", "R-HSA-9918432", "R-DDI-69656", "R-BTA-73856", "R-XTR-112382", "R-HSA-2029482", "R-MMU-2559580", "R-MMU-6807505", "R-RNO-174184", "R-BTA-9615933", "R-DRE-165159", "R-BTA-177929", "R-HSA-428930", "R-MMU-2173788", "R-MMU-1660517", "R-RNO-2514859", "R-SCE-6782135", "R-HSA-9930044", "R-SPO-159231", "R-DME-159231", "R-RNO-109704", "R-RNO-2173788", "R-DME-9013424", "R-HSA-8953750", "R-RNO-1660514", "R-HSA-171319", "R-HSA-6804758", "R-HSA-5610787", "R-MMU-2514859", "R-HSA-176407", "R-BTA-392451", "R-MMU-2995383", "R-DDI-69017", "R-MMU-6814122", "R-DME-209190", "R-SSC-3232142", "R-BTA-159230", "R-HSA-168276", "R-XTR-212300", "R-HSA-2894862", "R-DDI-1660516", "R-CFA-9009391", "R-CFA-9717207", "R-XTR-380284", "R-RNO-381676", "R-SSC-2467813", "R-RNO-4086398", "R-DRE-9615933", "R-DME-209440", "R-CEL-9764725", "R-BTA-428930", "R-HSA-9843940", 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"R-SCE-6804757", "R-MMU-9013420", "R-MMU-5663213", "R-HSA-76061", "R-MMU-1655829", "R-MMU-68867", "R-HSA-392851", "R-CFA-177929", "R-MMU-72163", "R-BTA-6782135", "R-DME-209461", "R-DRE-69601", "R-RNO-5628897", "R-HSA-141444", "R-DRE-420092", "R-HSA-9764725", "R-BTA-2173788", "R-GGA-5620912", "R-HSA-72702", "R-DRE-3371453", "R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-SPO-110314", "R-HSA-5696394", "R-RNO-9696264", "R-DME-69601", "R-DME-1632852", "R-HSA-2644606", "R-MMU-69273", "R-MMU-9860927", "R-DME-983168", "R-HSA-2467813", "R-HSA-6781827", "R-MMU-380972", "R-HSA-9772755", "R-MMU-8980692", "R-DDI-6791226", "R-RNO-77595", "R-DRE-191859", "R-HSA-9861718", "R-HSA-6782315", "R-HSA-1538133", "R-MMU-9772755", "R-DME-8953750", "R-SPO-9013420", "R-BTA-5696400", "R-DDI-5668599", "R-BTA-1538133", "R-SCE-72695", "R-MMU-72695", "R-BTA-8856828", "R-GGA-6783310", "R-DRE-9861718", "R-DME-209360", "R-DDI-1632852", "R-DME-5357905", "R-HSA-156711", "R-DME-72689", "R-BTA-392851", "R-RNO-72702", "R-DME-418594", "R-DDI-166208", "R-HSA-380270", "R-MMU-1169091", "R-HSA-72649", "R-MMU-8943724", "R-RNO-9856530", "R-HSA-9909649", "R-MMU-72187", "R-RNO-9770562", "R-XTR-8866654", "R-HSA-5696400", "R-XTR-2559580", "R-HSA-112314", "R-MMU-8953750", "R-DME-209155", "R-RNO-2995383", "R-MMU-5607764", "R-DRE-381753", "R-DME-69231", "R-HSA-72187", "R-DME-8964616", "R-HSA-5676590", "R-BTA-420092", "R-BTA-72689", "R-HSA-380320", "R-HSA-141430", "R-RNO-159230", "R-RNO-420092", "R-BTA-1296041", "R-MMU-9717207", "R-MMU-428930", "R-BTA-72695", "R-SCE-9013420", "R-MMU-1660514", "R-DDI-1660517", "R-HSA-4551638", "R-HSA-176408", "R-MMU-5620924", "R-SCE-9856530", "R-MMU-76042", "R-RNO-389357", "R-BTA-2485179", "R-CEL-6807505", "R-BTA-3371453", "R-MMU-6811436", "R-BTA-416476", "R-DME-3769402", "R-CEL-156827", "R-HSA-1169091", "R-HSA-8980692", "R-BTA-418555", "R-SCE-674695", "R-CEL-1296041", "R-GGA-8854518", "R-DRE-5628897", "R-HSA-110314", "R-HSA-8853884", "R-SPO-176408", "R-RNO-3371453", "R-RNO-8943724", "R-RNO-201722", "R-HSA-76066", "R-CEL-1632852", "R-CEL-73856", "R-HSA-416476", "R-SPO-3214847", "R-CFA-6814122", "R-MMU-69601", "R-SCE-975957", "R-HSA-3214841", "R-DME-5607761", "R-SCE-1257604", "R-HSA-381771", "R-HSA-9029569", "R-MMU-9648025", "R-HSA-5620912", "R-DRE-9909649", "R-HSA-5607764", "R-HSA-141405", "R-MMU-3769402", "R-DRE-111459", "R-XTR-201722", "R-HSA-8964616", "R-RNO-6782135", "R-CEL-6811436", "R-XTR-3301854", "R-XTR-68877", "R-DME-4641265", "R-RNO-204005", "R-SCE-9907900", "R-BTA-380270", "R-RNO-170822", "R-DRE-3214841", "R-DME-9841922", "R-MMU-166208", "R-RNO-5357956", "R-CFA-1296041", "R-DRE-3214858", "R-HSA-176417"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-XTR-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8951664:r:Neddylation", "R-MMU-1632852:r:Macroautophagy", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-XTR-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CFA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CEL-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-165159:r:MTOR signalling", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9634597:r:GPER1 signaling", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-BTA-418597:r:G alpha (z) signalling events", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-XTR-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-165159:r:MTOR signalling", "R-SSC-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-69231:r:Cyclin D associated events in G1", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-GGA-5689880:r:Ub-specific processing proteases", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-418555:r:G alpha (s) signalling events", "R-CEL-8951664:r:Neddylation", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-202040:r:G-protein activation", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-8951664:r:Neddylation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-XTR-5689880:r:Ub-specific processing proteases", "R-SSC-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-RNO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-418594:r:G alpha (i) signalling events", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-209421:r:Transcription activation by ARM", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-176417:r:Phosphorylation of Emi1", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CFA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-CEL-416476:r:G alpha (q) signalling events", "R-RNO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-72649:r:Translation initiation complex formation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9013424:r:RHOV GTPase cycle", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-428930:r:Thromboxane signalling through TP receptor", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-3214815:r:HDACs deacetylate histones", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-165159:r:MTOR signalling", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "R-XTR-5620924:r:Intraflagellar transport", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-1266695:r:Interleukin-7 signaling", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-3214815:r:HDACs deacetylate histones", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CFA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-XTR-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-166208:r:mTORC1-mediated signalling", "R-CFA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-DRE-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DRE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-CEL-69231:r:Cyclin D associated events in G1", "R-DDI-9033241:r:Peroxisomal protein import", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-BTA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-8951664:r:Neddylation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-XTR-3214847:r:HATs acetylate histones", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-4085377:r:SUMOylation of SUMOylation proteins", "R-DME-3214858:r:RMTs methylate histone arginines", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-68877:r:Mitotic Prometaphase", "R-CFA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-MMU-191859:r:snRNP Assembly", "R-SSC-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2485179:r:Activation of the phototransduction cascade", "R-RNO-5694530:r:Cargo concentration in the ER", "R-BTA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-GGA-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-69231:r:Cyclin D associated events in G1", "R-XTR-3214815:r:HDACs deacetylate histones", "R-RNO-3214847:r:HATs acetylate histones", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-RNO-9646399:r:Aggrephagy", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-3214815:r:HDACs deacetylate histones", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-DRE-8943724:r:Regulation of PTEN gene transcription", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-191859:r:snRNP Assembly", "R-SPO-9696273:r:RND1 GTPase cycle", "R-DRE-3214847:r:HATs acetylate histones", "R-CFA-202040:r:G-protein activation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-381753:r:Olfactory Signaling Pathway", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-SCE-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-CEL-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-SSC-5689880:r:Ub-specific processing proteases", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-SCE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-418597:r:G alpha (z) signalling events", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-SPO-72649:r:Translation initiation complex formation", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-3214847:r:HATs acetylate histones", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-CEL-418555:r:G alpha (s) signalling events", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-4086398:r:Ca2+ pathway", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-CFA-4086398:r:Ca2+ pathway", "R-MMU-9930044:r:Nuclear RNA decay", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-111458:r:Formation of apoptosome", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DRE-3371571:r:HSF1-dependent transactivation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-392170:r:ADP signalling through P2Y purinoceptor 12", "R-HSA-194138:r:Signaling by VEGF", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-BTA-381753:r:Olfactory Signaling Pathway", "R-BTA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-191859:r:snRNP Assembly", "R-DRE-2485179:r:Activation of the phototransduction cascade", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-418594:r:G alpha (i) signalling events", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-RNO-418594:r:G alpha (i) signalling events", "R-XTR-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9907900:r:Proteasome assembly", "R-BTA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-418594:r:G alpha (i) signalling events", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-DME-9037629:r:Lewis blood group biosynthesis", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-3214847:r:HATs acetylate histones", "R-XTR-191859:r:snRNP Assembly", "R-DRE-9646399:r:Aggrephagy", "R-BTA-166208:r:mTORC1-mediated signalling", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-GGA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-392170:r:ADP signalling through P2Y purinoceptor 12", "R-MMU-5694530:r:Cargo concentration in the ER", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-111458:r:Formation of apoptosome", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-202040:r:G-protein activation", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-DRE-9013407:r:RHOH GTPase cycle", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SPO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-420092:r:Glucagon-type ligand receptors", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-XTR-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-SSC-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DRE-165159:r:MTOR signalling", "R-BTA-177929:r:Signaling by EGFR", "R-HSA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-9930044:r:Nuclear RNA decay", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-109704:r:PI3K Cascade", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-209190:r:Phosphorylation of CI", "R-SSC-3232142:r:SUMOylation of ubiquitinylation proteins", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-RNO-4086398:r:Ca2+ pathway", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-428930:r:Thromboxane signalling through TP receptor", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-202040:r:G-protein activation", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-4086398:r:Ca2+ pathway", "R-CFA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-191859:r:snRNP Assembly", "R-SCE-114608:r:Platelet degranulation", "R-RNO-5610787:r:Hedgehog 'off' state", "R-DRE-111458:r:Formation of apoptosome", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-8964315:r:G beta:gamma signalling through BTK", "R-DDI-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5673000:r:RAF activation", "R-DME-5610787:r:Hedgehog 'off' state", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-191859:r:snRNP Assembly", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-XTR-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DDI-165159:r:MTOR signalling", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-983189:r:Kinesins", "R-CEL-9907900:r:Proteasome assembly", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-9907900:r:Proteasome assembly", "R-CEL-5610787:r:Hedgehog 'off' state", "R-DME-111458:r:Formation of apoptosome", "R-SSC-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-DRE-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-XTR-1538133:r:G0 and Early G1", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-109704:r:PI3K Cascade", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-176417:r:Phosphorylation of Emi1", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-XTR-8951664:r:Neddylation", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-9033241:r:Peroxisomal protein import", "R-DME-3214847:r:HATs acetylate histones", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-CEL-392170:r:ADP signalling through P2Y purinoceptor 12", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-XTR-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-983189:r:Kinesins", "R-SPO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-8951664:r:Neddylation", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-DDI-9646399:r:Aggrephagy", "R-SSC-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-DRE-3214815:r:HDACs deacetylate histones", "R-SPO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-176417:r:Phosphorylation of Emi1", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SSC-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-209441:r:WG ligand not bound to FZ receptors", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-1296041:r:Activation of G protein gated Potassium channels", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-XTR-9930044:r:Nuclear RNA decay", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9766229:r:Degradation of CDH1", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CFA-9634597:r:GPER1 signaling", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SSC-68877:r:Mitotic Prometaphase", "R-BTA-4570464:r:SUMOylation of RNA binding proteins", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-CFA-420092:r:Glucagon-type ligand receptors", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-9833110:r:RSV-host interactions", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-CEL-3214847:r:HATs acetylate histones", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-392170:r:ADP signalling through P2Y purinoceptor 12", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-CFA-8964315:r:G beta:gamma signalling through BTK", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-416476:r:G alpha (q) signalling events", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-HSA-163615:r:PKA activation", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-418597:r:G alpha (z) signalling events", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CFA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-5610787:r:Hedgehog 'off' state", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-XTR-5610787:r:Hedgehog 'off' state", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SSC-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-SCE-9696273:r:RND1 GTPase cycle", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3247509:r:Chromatin modifying enzymes", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9710421:r:Defective pyroptosis", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-1632852:r:Macroautophagy", "R-CFA-418594:r:G alpha (i) signalling events", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SSC-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9634597:r:GPER1 signaling", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-72649:r:Translation initiation complex formation", "R-SSC-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-3214847:r:HATs acetylate histones", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-114608:r:Platelet degranulation", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-BTA-4615885:r:SUMOylation of DNA replication proteins", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-9907900:r:Proteasome assembly", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-CFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DDI-3247509:r:Chromatin modifying enzymes", "R-XTR-1632852:r:Macroautophagy", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-1632852:r:Macroautophagy", "R-XTR-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9673766:r:Signaling by cytosolic PDGFRA and PDGFRB fusion proteins", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-165159:r:MTOR signalling", "R-BTA-165159:r:MTOR signalling", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-BTA-9646399:r:Aggrephagy", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-SPO-1632852:r:Macroautophagy", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-SSC-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-114608:r:Platelet degranulation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-CEL-202040:r:G-protein activation", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-3295583:r:TRP channels", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-5626978:r:TNFR1-mediated ceramide production", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-983189:r:Kinesins", "R-SCE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-DRE-4641265:r:Repression of WNT target genes", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-DRE-202040:r:G-protein activation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-418217:r:G beta:gamma signalling through PLC beta", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-BTA-3214841:r:PKMTs methylate histone lysines", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-1632852:r:Macroautophagy", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-3214815:r:HDACs deacetylate histones", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-5610787:r:Hedgehog 'off' state", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-9033241:r:Peroxisomal protein import", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-SSC-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-DME-114608:r:Platelet degranulation", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-420092:r:Glucagon-type ligand receptors", "R-RNO-72649:r:Translation initiation complex formation", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-167161:r:HIV Transcription Initiation", "R-MMU-9646399:r:Aggrephagy", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-DME-432620:r:Dephosphorylation of PER", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-418597:r:G alpha (z) signalling events", "R-CEL-418597:r:G alpha (z) signalling events", "R-CFA-416476:r:G alpha (q) signalling events", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-72649:r:Translation initiation complex formation", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-GGA-8951664:r:Neddylation", "R-MMU-418597:r:G alpha (z) signalling events", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-DME-209396:r:Phosphorylation of ARM", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-BTA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DME-9646399:r:Aggrephagy", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-CFA-381753:r:Olfactory Signaling Pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-DME-9013420:r:RHOU GTPase cycle", "R-GGA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-418597:r:G alpha (z) signalling events", "R-DME-8951664:r:Neddylation", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9766229:r:Degradation of CDH1", "R-DME-9930044:r:Nuclear RNA decay", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-MMU-202040:r:G-protein activation", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-8980692:r:RHOA GTPase cycle", "R-BTA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DRE-1538133:r:G0 and Early G1", "R-CEL-4641265:r:Repression of WNT target genes", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-9696273:r:RND1 GTPase cycle", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-CFA-500657:r:Presynaptic function of Kainate receptors", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-69231:r:Cyclin D associated events in G1", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-4641265:r:Repression of WNT target genes", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-3214815:r:HDACs deacetylate histones", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-4641265:r:Repression of WNT target genes", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-418594:r:G alpha (i) signalling events", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-CFA-418597:r:G alpha (z) signalling events", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-9930044:r:Nuclear RNA decay", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-XTR-8943724:r:Regulation of PTEN gene transcription", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SSC-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-4641265:r:Repression of WNT target genes", "R-HSA-9022537:r:Loss of MECP2 binding ability to the NCoR/SMRT complex", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-3214847:r:HATs acetylate histones", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-CEL-5620924:r:Intraflagellar transport", "R-DME-1538133:r:G0 and Early G1", "R-BTA-1632852:r:Macroautophagy", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-CEL-6782135:r:Dual incision in TC-NER", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-8951664:r:Neddylation", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5620924:r:Intraflagellar transport", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-9766229:r:Degradation of CDH1", "R-XTR-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-350054:r:Notch-HLH transcription pathway", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CFA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-DRE-5626978:r:TNFR1-mediated ceramide production", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-CFA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-4086398:r:Ca2+ pathway", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9707616:r:Heme signaling", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-DDI-1266695:r:Interleukin-7 signaling", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-GGA-1632852:r:Macroautophagy", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DME-428930:r:Thromboxane signalling through TP receptor", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-418594:r:G alpha (i) signalling events", "R-DRE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-CEL-428930:r:Thromboxane signalling through TP receptor", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DRE-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-212436:r:Generic Transcription Pathway", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-429958:r:mRNA decay by 3' 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phospholipids in phagocytosis", "R-MMU-9013408:r:RHOG GTPase cycle", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-8941237:r:Invadopodia formation", "R-SPO-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-1483166:r:Synthesis of PA", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SCE-9035034:r:RHOF GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-8941237:r:Invadopodia formation", "R-RNO-9696264:r:RND3 GTPase cycle", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-983189:r:Kinesins", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-2672351:r:Stimuli-sensing channels", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1483148:r:Synthesis of PG", "R-SPO-8941237:r:Invadopodia formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-BTA-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-8941237:r:Invadopodia formation", "R-SPO-1483166:r:Synthesis of PA", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SCE-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-983189:r:Kinesins", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-SCE-1483166:r:Synthesis of PA", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases"], "type": "Domain"}, "IPR001684": {"description": "Large ribosomal subunit protein bL27", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bL27", "pathway_ids": ["R-MMU-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Family"}, "IPR001689": {"description": "Flagellar motor switch protein FliM", "go_ids": ["GO:0003774", "GO:0009425", "GO:0071973"], "go_terms": ["GO:0003774:cytoskeletal motor activity:F", "GO:0009425:bacterial-type flagellum basal body:C", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "Flag_FliM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001690": {"description": "Autoinducer synthase", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "Autoind_synthase", "pathway_ids": ["PWY-6157"], "pathways": ["PWY-6157:t:autoinducer AI-1 biosynthesis"], "type": "Family"}, "IPR001693": {"description": "Calcitonin peptide-like", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Calcitonin_peptide-like", "pathway_ids": ["R-MMU-419812", "R-CFA-419812", "R-HSA-977225", "R-HSA-418555", "R-HSA-210745", "R-RNO-419812", "R-MMU-418555", "R-HSA-419812"], "pathways": ["R-MMU-419812:r:Calcitonin-like ligand receptors", "R-CFA-419812:r:Calcitonin-like ligand receptors", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-RNO-419812:r:Calcitonin-like ligand receptors", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-419812:r:Calcitonin-like ligand receptors"], "type": "Domain"}, "IPR001694": {"description": "NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "NADH_UbQ_OxRdtase_su1/FPO", "pathway_ids": ["R-HSA-5419276", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-DRE-611105", "R-RNO-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-GGA-5419276", "R-RNO-5419276", "R-GGA-611105", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9837999", "R-CEL-5419276", "R-DRE-5419276", "R-GGA-6799198"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-RNO-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-611105:r:Respiratory electron transport", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-5419276:r:Mitochondrial translation termination", "R-GGA-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR001695": {"description": "Lysyl oxidase", "go_ids": ["GO:0005507", "GO:0016641"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0016641:oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor:F"], "name": "Lysyl_oxidase", "pathway_ids": ["R-BTA-2243919", "R-HSA-2243919", "R-MMU-1566948", "R-BTA-1566948", "R-DRE-2243919", "R-RNO-2243919", "R-HSA-1566948", "R-RNO-1566948", "R-MMU-2243919"], "pathways": 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"R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR001699": {"description": "T-box transcription factor", "go_ids": ["GO:0003700", "GO:0006355", "GO:0000978"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding:F"], "name": "TF_T-box", "pathway_ids": ["R-MMU-9856649", "R-MMU-8953750", "R-HSA-2032785", "R-HSA-9942503", "R-RNO-9856649", "R-CEL-2032785", "R-HSA-9758919", "R-DME-9856649", "R-HSA-9824272", "R-HSA-8953750", "R-HSA-5578768", "R-HSA-9754189", "R-HSA-9827857", "R-RNO-2032785", "R-HSA-9832991", "R-HSA-9823730", "R-HSA-9733709", "R-HSA-9793380", "R-HSA-9796292", "R-HSA-9856649", "R-CEL-8953750", "R-MMU-2032785", "R-CEL-9856649", 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(TAZ)-stimulated gene expression", "R-HSA-9832991:r:Formation of the posterior neural plate", "R-HSA-9823730:r:Formation of definitive endoderm", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DRE-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "type": "Family"}, "IPR001701": {"description": "Glycoside hydrolase family 9", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate 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"R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-2424491:r:DAP12 signaling", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1"], "type": "Domain"}, "IPR001712": {"description": "Type III secretion system FHIPEP", "go_ids": ["GO:0009306", "GO:0016020"], "go_terms": ["GO:0009306:protein secretion:P", "GO:0016020:membrane:C"], "name": "T3SS_FHIPEP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001713": {"description": "Proteinase inhibitor I25A, stefin", "go_ids": ["GO:0004866"], "go_terms": ["GO:0004866:endopeptidase inhibitor activity:F"], 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"R-RNO-5218920", "R-RNO-912631", "R-DDI-389359", "R-CEL-446343", "R-GGA-416482", "R-BTA-4420097", "R-HSA-9662360", "R-SCE-8980692", "R-BTA-6811558", "R-BTA-2500257", "R-BTA-438066", "R-RNO-375165", "R-HSA-512988", "R-DME-446353", "R-HSA-6802955", "R-RNO-193648", "R-RNO-446343", "R-DDI-6798695", "R-MMU-9035034", "R-HSA-6802948", "R-HSA-983695", "R-MMU-380259", "R-HSA-3000171", "R-DDI-5673001", "R-RNO-9013148", "R-RNO-5663220", "R-XTR-380320", "R-DME-5218920", "R-HSA-9748787", "R-CEL-1433557", "R-DME-193648", "R-CEL-446388", "R-BTA-8980692", "R-MMU-9696264", "R-BTA-9648025", "R-RNO-9013420", "R-HSA-9609736", "R-MMU-9013418", "R-DDI-9013418", "R-RNO-380270", "R-RNO-2871796", "R-RNO-141444", "R-MMU-5674135", "R-RNO-1257604", "R-RNO-8980692", "R-MMU-8964616", "R-SCE-5626467", "R-HSA-114608", "R-CEL-9748787", "R-RNO-416482", "R-RNO-389359", "R-RNO-2565942", "R-HSA-9013148", "R-BTA-380320", "R-GGA-9013149", "R-RNO-9013418", "R-XTR-9648025", "R-HSA-8983711", "R-RNO-2132295", "R-HSA-3000170", "R-HSA-9696270", "R-DME-6798695", "R-HSA-2871809", "R-BTA-446388", "R-MMU-9013424", "R-MMU-1257604", "R-DME-512988", "R-BTA-416482", "R-HSA-446353", "R-HSA-3928665", "R-BTA-983695", "R-RNO-983695", "R-RNO-9648025", "R-CEL-114604", "R-MMU-9696273", "R-HSA-9725370", "R-HSA-6798695", "R-GGA-9035034", "R-CEL-8980692", "R-MMU-9013106", "R-MMU-2467813", "R-BTA-6798695", "R-DME-912631", "R-MMU-4420097", "R-MMU-2565942", "R-RNO-380320", "R-BTA-389359", "R-HSA-446343", "R-BTA-5620912", "R-DME-3928665", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-9013408", "R-DDI-9013423", "R-DME-6807878", "R-RNO-5673001", "R-RNO-9748787", "R-HSA-373753", "R-MMU-1433557", "R-GGA-9013148", "R-MMU-141444", "R-HSA-3928664", "R-HSA-2029482", "R-XTR-380259", "R-HSA-5673001", "R-HSA-6811558", "R-SPO-8980692", "R-RNO-1433557", "R-MMU-373753", "R-DME-2871796", "R-DME-446388", "R-MMU-445095", "R-MMU-9013406", "R-DDI-5627123", "R-MMU-6798695", "R-MMU-8854518", "R-RNO-2467813", "R-HSA-1257604", "R-MMU-114608", "R-SPO-6798695", "R-HSA-2132295", "R-RNO-2500257", "R-XTR-2467813", "R-BTA-5663220", "R-MMU-6807878", "R-DME-9013424", "R-MMU-9013148", "R-HSA-1221632", "R-HSA-375165", "R-SPO-114608", "R-RNO-2029482", "R-RNO-114608", "R-HSA-2565942", "R-HSA-9035034", "R-DME-9748787", "R-RNO-8852276", "R-SCE-9013424", "R-HSA-9617324", "R-MMU-2500257", "R-HSA-2500257", "R-RNO-390522", "R-RNO-446353", "R-RNO-8854518", "R-MMU-5218920", "R-CEL-445144", "R-HSA-9927432", "R-XTR-5663220", "R-XTR-380284", "R-DME-983695", "R-HSA-983168", "R-MMU-1169408", "R-MMU-2029482", "R-HSA-5627123", "R-HSA-438066", "R-DDI-6807878", "R-CEL-4420097", "R-MMU-416482", "R-HSA-390522", "R-HSA-9013406", "R-HSA-9664422", "R-HSA-380259", "R-XTR-2500257", "R-DDI-1169092", "R-CEL-5218920", "R-DME-9013423", "R-HSA-9013409", "R-RNO-445095", "R-HSA-9013418", "R-MMU-114604", "R-HSA-9918485", "R-MMU-9013408", "R-SCE-114608", "R-DDI-446353", "R-DDI-114608", "R-HSA-442982", "R-MMU-380320", "R-XTR-141444", "R-DME-9013148", "R-HSA-5218920", "R-MMU-9013420", "R-RNO-6811558", "R-BTA-2565942", "R-HSA-389359", "R-RNO-380284", "R-MMU-5620912", "R-HSA-446107", "R-DDI-445144", "R-MMU-5673001", "R-HSA-114604", "R-SPO-5626467", "R-GGA-9013420", "R-DME-9013149", "R-HSA-182971", "R-HSA-2424491", "R-DME-114608", "R-DME-5627123", "R-HSA-983231", "R-HSA-416482", "R-HSA-141444", "R-MMU-380270", "R-HSA-9696264", "R-MMU-9013423", "R-HSA-2022090", "R-DME-1257604", "R-DME-416482", "R-MMU-193648", "R-HSA-9013026", "R-HSA-445144", "R-MMU-5627123", "R-HSA-264870", "R-MMU-5663220", "R-MMU-446107", "R-HSA-9656223", "R-BTA-2029482", "R-DME-5673001", "R-HSA-2467813", "R-HSA-445095", "R-MMU-430116", "R-RNO-9035034", "R-MMU-8980692", "R-MMU-8852276", "R-SCE-6798695", "R-HSA-9013106", "R-MMU-380284", "R-RNO-9027284", "R-DME-1433557", "R-SPO-9013406", "R-HSA-9013423", "R-HSA-68877", "R-MMU-512988", "R-SPO-9013420", "R-GGA-193648", "R-MMU-9027284", "R-BTA-1433557", "R-BTA-512988", "R-CEL-193648", "R-CEL-9013423", "R-DDI-2029482", "R-MMU-3928664", "R-RNO-68877", "R-MMU-912631", "R-RNO-446107", "R-MMU-5626467", "R-DDI-5687128", "R-DDI-392517", "R-HSA-9913351", "R-GGA-114608", "R-HSA-380270", "R-XTR-8852276", "R-SCE-9013106", "R-RNO-380259", "R-CEL-3928665", "R-DDI-3928662", "R-BTA-9013404", "R-MMU-264870", "R-BTA-1257604", "R-DME-6803207", "R-HSA-5663220", "R-HSA-446388", "R-BTA-9027284", "R-DDI-9013404", "R-MMU-9013149", "R-XTR-8854518", "R-DME-9013420", "R-SPO-6807878", "R-DDI-354192", "R-MMU-446353", "R-MMU-389359", "R-MMU-182971", "R-HSA-5674135", "R-DME-375165", "R-HSA-430116", "R-DME-114604", "R-CEL-912631", "R-HSA-380284", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-8854518", "R-CEL-416482", "R-MMU-446388", "R-BTA-9035034", "R-BTA-380259", "R-HSA-4420097", "R-SPO-9013106", "R-MMU-2871796", "R-DME-9035034", "R-HSA-380320", "R-DME-2424491", "R-BTA-2871809", "R-HSA-9649948", "R-SCE-9013420", "R-BTA-9013418", "R-CEL-9013148", "R-DME-438066", "R-DDI-193648", "R-MMU-9748787", "R-DME-445095", "R-DME-8980692", "R-MMU-438066", "R-MMU-390522", "R-HSA-8950505", "R-HSA-2219530", "R-HSA-9648025", "R-BTA-912631", "R-MMU-445144", "R-GGA-9013418", "R-RNO-8964616", "R-CEL-446353", "R-BTA-390522", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-DME-445144", "R-MMU-9913351", "R-HSA-9620244", "R-HSA-381676", "R-SPO-9013424", "R-BTA-114604", "R-RNO-4420097", "R-MMU-375165", "R-HSA-5626467", "R-HSA-5368598", "R-HSA-9619665", "R-XTR-380270", "R-HSA-1169408", "R-RNO-5620912", "R-DDI-9013149", "R-CEL-9013149", "R-DME-6811558", "R-BTA-114608", "R-BTA-2467813", "R-DDI-381676", "R-XTR-5620912", "R-SCE-9013406", "R-HSA-6802946", "R-DME-2871809", "R-BTA-2871796", "R-HSA-9619229", "R-MMU-446343", "R-HSA-5620912", "R-MMU-9648025", "R-BTA-380284", "R-HSA-193648", "R-HSA-9013420", "R-DDI-171007", "R-CEL-9913351", "R-RNO-6807878", "R-HSA-8964616", "R-HSA-9662361", "R-HSA-6807878", "R-HSA-8852276", "R-HSA-9679191", "R-MMU-983695", "R-HSA-1433557", "R-XTR-68877", "R-DME-9013418", "R-RNO-9913351", "R-DDI-5621575", "R-RNO-114604", "R-HSA-9703465", "R-BTA-9013408", "R-GGA-8964616", "R-BTA-8854518", "R-BTA-380270", "R-MMU-2871809", "R-MMU-9013026", "R-XTR-2565942", "R-MMU-2424491", "R-RNO-264870", "R-MMU-9696270", "R-DME-4420097", "R-BTA-141444", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8951664:r:Neddylation", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-GGA-416482:r:G alpha (12/13) signalling events", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-SCE-8980692:r:RHOA GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-RNO-193648:r:NRAGE signals death through JNK", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-DME-193648:r:NRAGE signals death through JNK", "R-CEL-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-SCE-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9748787:r:Azathioprine ADME", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-8983711:r:OAS antiviral response", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-9035034:r:RHOF GTPase cycle", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-912631:r:Regulation of signaling by CBL", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-9748787:r:Azathioprine ADME", "R-HSA-373753:r:Nephrin family interactions", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-8980692:r:RHOA GTPase cycle", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-373753:r:Nephrin family interactions", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-114608:r:Platelet degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-SPO-114608:r:Platelet degranulation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-114608:r:Platelet degranulation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9748787:r:Azathioprine ADME", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-390522:r:Striated Muscle Contraction", "R-RNO-446353:r:Cell-extracellular matrix interactions", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-XTR-5663220:r:RHO GTPases Activate Formins", 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"R-MMU-2424491:r:DAP12 signaling", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR001719": {"description": "AP endonuclease 2", "go_ids": ["GO:0003677", "GO:0006281", "GO:0008270"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006281:DNA repair:P", "GO:0008270:zinc ion binding:F"], "name": "AP_endonuc_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001721": {"description": "Threonine dehydratase, ACT-like domain", "go_ids": [], "go_terms": [], "name": "TD_ACT-like", "pathway_ids": ["PWY-8443"], "pathways": ["PWY-8443:t:cyclosporin A biosynthesis"], "type": "Domain"}, "IPR001722": {"description": "Glycoside hydrolase, family 7", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, 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"R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-189451:r:Heme biosynthesis"], "type": "Family"}, "IPR001732": {"description": "UDP-glucose/GDP-mannose dehydrogenase, N-terminal", "go_ids": ["GO:0016616", "GO:0051287"], "go_terms": ["GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F", "GO:0051287:NAD binding:F"], "name": "UDP-Glc/GDP-Man_DH_N", "pathway_ids": ["PWY-7346", "PWY-7820", "R-BTA-173599", "R-HSA-173599", "R-CEL-173599", "R-RNO-173599", "R-MMU-173599", "R-DME-173599"], "pathways": ["PWY-7346:t:UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "R-BTA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-CEL-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-RNO-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DME-173599:r:Formation of the active cofactor, UDP-glucuronate"], "type": "Domain"}, "IPR001733": {"description": "Peptidase S26B", "go_ids": ["GO:0008233", "GO:0016020", "GO:0051604"], "go_terms": ["GO:0008233:peptidase activity:F", "GO:0016020:membrane:C", "GO:0051604:protein maturation:P"], "name": "Peptidase_S26B", "pathway_ids": ["R-HSA-1799339", "R-HSA-9918432", "R-CFA-422085", "R-HSA-422085", "R-RNO-9768727", "R-MMU-422085", "R-BTA-422085", "R-CFA-9768727", "R-HSA-9828806", "R-BTA-9768727", "R-RNO-422085", "R-HSA-381771", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-400511"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Family"}, "IPR001734": {"description": "Sodium/solute symporter", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "Na/solute_symporter", "pathway_ids": ["R-MMU-196807", "R-MMU-9958517", "R-DRE-196807", "R-CEL-9958517", "R-HSA-5656364", "R-RNO-9958517", "R-SSC-8981373", "R-DME-9958517", "R-MMU-429593", "R-HSA-196780", "R-HSA-199220", "R-BTA-428643", "R-CFA-429593", "R-HSA-428643", "R-MMU-199220", "R-RNO-199220", "R-DME-264642", "R-HSA-425397", "R-HSA-209968", "R-RNO-8981373", "R-MMU-189200", "R-RNO-189200", "R-RNO-196780", "R-XTR-428643", "R-DRE-189200", "R-DRE-428643", "R-CEL-264642", "R-MMU-8981373", "R-HSA-5619114", "R-DRE-9958790", "R-MMU-428643", "R-RNO-209968", "R-HSA-5658208", "R-XTR-9958790", "R-HSA-9958790", "R-MMU-9958790", "R-HSA-196807", "R-HSA-264642", "R-HSA-8981373", "R-HSA-189200", "R-BTA-189200", "R-SSC-189200", "R-MMU-196780", "R-MMU-425397", "R-RNO-429593", "R-MMU-264642", "R-HSA-9958517", "R-XTR-196807", "R-RNO-264642", "R-RNO-425397", "R-MMU-209968", "R-HSA-5658471", "R-RNO-9958790", "R-HSA-429593", "R-HSA-5619096"], "pathways": ["R-MMU-196807:r:Nicotinate metabolism", "R-MMU-9958517:r:SLC-mediated bile acid transport", "R-DRE-196807:r:Nicotinate metabolism", "R-CEL-9958517:r:SLC-mediated bile acid transport", "R-HSA-5656364:r:Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)", "R-RNO-9958517:r:SLC-mediated bile acid transport", "R-SSC-8981373:r:Intestinal hexose absorption", "R-DME-9958517:r:SLC-mediated bile acid transport", "R-MMU-429593:r:Inositol transporters", "R-HSA-196780:r:Biotin transport and metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-BTA-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-CFA-429593:r:Inositol transporters", "R-HSA-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-HSA-209968:r:Thyroxine biosynthesis", "R-RNO-8981373:r:Intestinal hexose absorption", "R-MMU-189200:r:Cellular hexose transport", "R-RNO-189200:r:Cellular hexose transport", "R-RNO-196780:r:Biotin transport and metabolism", "R-XTR-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-DRE-189200:r:Cellular hexose transport", "R-DRE-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-8981373:r:Intestinal hexose absorption", "R-HSA-5619114:r:Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "R-DRE-9958790:r:SLC-mediated transport of inorganic anions", "R-MMU-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-RNO-209968:r:Thyroxine biosynthesis", "R-HSA-5658208:r:Defective SLC5A2 causes renal glucosuria (GLYS1)", "R-XTR-9958790:r:SLC-mediated transport of inorganic anions", "R-HSA-9958790:r:SLC-mediated transport of inorganic anions", "R-MMU-9958790:r:SLC-mediated transport of inorganic anions", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-8981373:r:Intestinal hexose absorption", "R-HSA-189200:r:Cellular hexose transport", "R-BTA-189200:r:Cellular hexose transport", "R-SSC-189200:r:Cellular hexose transport", "R-MMU-196780:r:Biotin transport and metabolism", "R-MMU-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-RNO-429593:r:Inositol transporters", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9958517:r:SLC-mediated bile acid transport", "R-XTR-196807:r:Nicotinate metabolism", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-MMU-209968:r:Thyroxine biosynthesis", "R-HSA-5658471:r:Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "R-RNO-9958790:r:SLC-mediated transport of inorganic anions", "R-HSA-429593:r:Inositol transporters", "R-HSA-5619096:r:Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)"], "type": "Family"}, "IPR001736": {"description": "Phospholipase D/Transphosphatidylase", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "PLipase_D/transphosphatidylase", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-SPO-2029485", "R-RNO-1483166", "R-MMU-8980692", "R-SCE-2029485", "R-RNO-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-HSA-2029485", "R-RNO-9013149", "R-MMU-9013404", "R-XTR-1483166", "R-HSA-1483148", "R-HSA-1483166", "R-DDI-9013149", "R-DDI-1855204", "R-RNO-2029485", "R-SCE-8980692", "R-SPO-1483166", "R-HSA-9013148", "R-BTA-1483166", "R-MMU-2029485", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-DDI-2029485", "R-MMU-1855204", "R-BTA-2029485", "R-HSA-5601884", "R-DDI-6798695", "R-CEL-1855204", "R-XTR-2029485", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-1483166", "R-HSA-9013149", "R-HSA-8980692", "R-DDI-1483166", "R-HSA-1855204", "R-MMU-6798695", "R-DDI-9013404", "R-CEL-2029485", "R-MMU-9013149", "R-SCE-1483166", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-1483166:r:Synthesis of PA", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-1483148:r:Synthesis of PG", "R-HSA-1483166:r:Synthesis of PA", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-1483166:r:Synthesis of PA", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-1483166:r:Synthesis of PA", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-DDI-6798695:r:Neutrophil degranulation", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-XTR-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DDI-1483166:r:Synthesis of PA", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-CEL-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-SCE-1483166:r:Synthesis of PA", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR001737": {"description": "Ribosomal RNA adenine methyltransferase KsgA/Erm", "go_ids": [], "go_terms": [], "name": "KsgA/Erm", "pathway_ids": ["R-HSA-6793080", "R-MMU-163282", "R-HSA-2151201", "R-SPO-163282", "R-BTA-163282", "R-DME-163282", "R-SCE-163282", "R-HSA-163282", "R-RNO-163282", "R-HSA-6790901"], "pathways": ["R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-MMU-163282:r:Mitochondrial transcription initiation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-163282:r:Mitochondrial transcription initiation", "R-BTA-163282:r:Mitochondrial transcription initiation", "R-DME-163282:r:Mitochondrial transcription initiation", "R-SCE-163282:r:Mitochondrial transcription initiation", "R-HSA-163282:r:Mitochondrial transcription initiation", "R-RNO-163282:r:Mitochondrial transcription initiation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR001738": {"description": "Rab protein geranylgeranyltransferase component A", "go_ids": ["GO:0005968", "GO:0006886", "GO:0018344"], "go_terms": ["GO:0005968:Rab-protein geranylgeranyltransferase complex:C", "GO:0006886:intracellular protein transport:P", "GO:0018344:protein geranylgeranylation:P"], "name": "Rab_escort", "pathway_ids": ["R-CEL-6803205", "R-DME-6803205", "R-RNO-6803205", "R-MMU-6803205", "R-CEL-8876198", "R-RNO-8873719", "R-HSA-8873719", "R-MMU-8876198", "R-CEL-8873719", "R-DME-8876198", "R-DME-8873719", "R-RNO-8876198", "R-HSA-8876198", "R-HSA-6803205", "R-MMU-8873719"], "pathways": ["R-CEL-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DME-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-RNO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-MMU-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-8873719:r:RAB geranylgeranylation", "R-HSA-8873719:r:RAB geranylgeranylation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8873719:r:RAB geranylgeranylation", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8873719:r:RAB geranylgeranylation", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-MMU-8873719:r:RAB geranylgeranylation"], "type": "Family"}, "IPR001739": {"description": "Methyl-CpG DNA binding", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Methyl_CpG_DNA-bd", "pathway_ids": ["R-HSA-9022702", "R-HSA-73728", "R-MMU-73762", "R-HSA-110357", "R-HSA-9022692", "R-HSA-427413", "R-MMU-3214815", "R-HSA-9022538", "R-HSA-6804758", "R-HSA-9022535", "R-HSA-9844594", "R-HSA-3214841", "R-HSA-9845323", "R-HSA-9843970", "R-DME-3214841", "R-HSA-8943724", "R-MMU-9022692", "R-HSA-110329", "R-MMU-110329", "R-MMU-5689603", "R-MMU-110357", "R-DME-6804759", "R-HSA-9022707", "R-MMU-3214841", "R-MMU-9843940", "R-DRE-9843940", "R-DME-9772755", "R-MMU-3899300", "R-RNO-9022692", "R-DRE-9843970", "R-HSA-9022537", "R-HSA-110328", "R-HSA-9022534", 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"R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DME-3214841:r:PKMTs methylate histone lysines", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-5689603:r:UCH proteinases", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-DME-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-9022707:r:MECP2 regulates transcription factors", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-9772755:r:Formation of 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"R-DME-3214847:r:HATs acetylate histones", "R-DME-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-5689603:r:UCH proteinases", "R-HSA-3899300:r:SUMOylation of transcription cofactors"], "type": "Domain"}, "IPR001742": {"description": "Outer capsid protein VP2, Orbivirus", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Capsid_VP2_Orbivir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001743": {"description": "Photosystem II PsbT", "go_ids": ["GO:0009539", "GO:0015979", "GO:0016020", "GO:0009523"], "go_terms": ["GO:0009539:photosystem II reaction center:C", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C", "GO:0009523:photosystem II:C"], "name": "PSII_PsbT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001746": {"description": "Polyhedrin", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Polyhedrin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001747": {"description": "Vitellogenin, middle region", "go_ids": ["GO:0005319", "GO:0006869"], "go_terms": ["GO:0005319:lipid carrier activity:F", "GO:0006869:lipid transport:P"], "name": "Vitellogenin_M", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-DME-8964041", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-SSC-8964041", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-HSA-202733", "R-RNO-5686938", "R-SSC-8963888", "R-MMU-3000471", "R-MMU-8964041", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-DRE-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-RNO-8964041", "R-HSA-8957275", "R-SSC-8866423", "R-RNO-3000480", "R-HSA-8964038", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-DME-8964041:r:LDL remodeling", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-SSC-8964041:r:LDL remodeling", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-SSC-8963888:r:Chylomicron assembly", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-MMU-8964041:r:LDL remodeling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-DRE-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-RNO-8964041:r:LDL remodeling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-8866423:r:VLDL assembly", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-8964038:r:LDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR001748": {"description": "Pre-mRNA-splicing factor BUD31", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "BUD31", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-CEL-72163", "R-SPO-72163", "R-HSA-9918481", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR001750": {"description": "NADH:quinone oxidoreductase/Mrp antiporter, transmembrane domain", "go_ids": [], "go_terms": [], "name": "ND/Mrp_TM", "pathway_ids": ["R-HSA-5419276", "R-SSC-5419276", "R-DME-6799198", "R-HSA-6799198", "R-MMU-6799198", "R-RNO-6799198", "R-DRE-611105", "R-SSC-6799198", "R-GGA-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-GGA-5419276", "R-RNO-5419276", "R-GGA-611105", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9837999", "R-CEL-5419276", "R-DRE-5419276", "R-BTA-6799198", "R-SSC-611105", "R-BTA-611105"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-DME-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-SSC-6799198:r:Complex I biogenesis", "R-GGA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-611105:r:Respiratory electron transport", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-5419276:r:Mitochondrial translation termination", "R-BTA-6799198:r:Complex I biogenesis", "R-SSC-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR001752": {"description": "Kinesin motor domain", "go_ids": ["GO:0005524", "GO:0007018", "GO:0003777", "GO:0008017"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0007018:microtubule-based movement:P", "GO:0003777:microtubule motor activity:F", "GO:0008017:microtubule binding:F"], "name": "Kinesin_motor_dom", "pathway_ids": ["R-MMU-5632684", "R-RNO-5625970", "R-BTA-983189", "R-RNO-983189", "R-DME-216217", "R-HSA-264876", "R-MMU-2467813", "R-DRE-5632684", "R-MMU-68877", "R-HSA-6811434", "R-XTR-6811434", "R-SPO-9696273", "R-MMU-5610787", "R-MMU-5620912", "R-MMU-5620924", "R-MMU-6811434", "R-GGA-6811434", "R-HSA-5620924", "R-MMU-141444", "R-MMU-5635838", "R-MMU-5625900", "R-HSA-437239", "R-HSA-141444", "R-HSA-9648025", "R-DME-68884", "R-CEL-5620924", "R-RNO-5663220", "R-CEL-983189", "R-DRE-983189", "R-HSA-68884", "R-HSA-5635838", "R-HSA-1445148", "R-RNO-2467813", "R-RNO-5620924", "R-GGA-983189", "R-HSA-9609736", "R-MMU-5663220", "R-RNO-141444", "R-HSA-2132295", "R-BTA-68884", "R-HSA-5625900", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-983189", "R-DME-209338", "R-DME-209214", "R-DME-983189", "R-SPO-68884", "R-HSA-68877", "R-HSA-5610787", "R-DME-209159", "R-MMU-2132295", "R-MMU-9648025", "R-HSA-5620912", "R-DME-216119", "R-SCE-983189", "R-BTA-2132295", "R-DME-209190", "R-MMU-2500257", "R-DME-209360", "R-RNO-2132295", "R-RNO-6811434", "R-HSA-2500257", "R-MMU-437239", "R-HSA-9696270", "R-RNO-68877", "R-DDI-5610787", "R-HSA-390471", "R-MMU-68884", "R-DDI-983189", "R-MMU-5625970", "R-SPO-983189", "R-HSA-5632684", "R-DDI-68884", "R-XTR-983189", "R-HSA-983189", "R-HSA-5663220", "R-RNO-9648025", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9725370", "R-HSA-5625970", "R-HSA-9696273"], "pathways": ["R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-5625970:r:RHO GTPases activate KTN1", "R-BTA-983189:r:Kinesins", "R-RNO-983189:r:Kinesins", "R-DME-216217:r:Activation of SMO", "R-HSA-264876:r:Insulin processing", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DRE-5632684:r:Hedgehog 'on' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-9696273:r:RND1 GTPase cycle", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620924:r:Intraflagellar transport", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5635838:r:Activation of SMO", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-68884:r:Mitotic Telophase/Cytokinesis", "R-CEL-5620924:r:Intraflagellar transport", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-983189:r:Kinesins", "R-DRE-983189:r:Kinesins", "R-HSA-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-5635838:r:Activation of SMO", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-GGA-983189:r:Kinesins", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2132295:r:MHC class II antigen presentation", "R-BTA-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-983189:r:Kinesins", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209214:r:Phosphorylation of SMO", "R-DME-983189:r:Kinesins", "R-SPO-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-209159:r:Assembly of the CI containing complexes", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-216119:r:Activation of CI", "R-SCE-983189:r:Kinesins", "R-BTA-2132295:r:MHC class II antigen presentation", "R-DME-209190:r:Phosphorylation of CI", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-437239:r:Recycling pathway of L1", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-68877:r:Mitotic Prometaphase", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-68884:r:Mitotic Telophase/Cytokinesis", "R-DDI-983189:r:Kinesins", "R-MMU-5625970:r:RHO GTPases activate KTN1", "R-SPO-983189:r:Kinesins", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DDI-68884:r:Mitotic Telophase/Cytokinesis", "R-XTR-983189:r:Kinesins", "R-HSA-983189:r:Kinesins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5625970:r:RHO GTPases activate KTN1", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR001753": {"description": "Enoyl-CoA hydratase/isomerase-like domain", "go_ids": [], "go_terms": [], "name": "Enoyl-CoA_hydra/iso", "pathway_ids": ["PWY-8182", "PWY-6458", "PWY-7007", "PWY-8354", "PWY-8347", "PWY-7654", "PWY-5138", "PWY-6446", "PWY-5136", "PWY-8181", "PWY-1361", "PWY-6443", "PWY-8179", "PWY-7606", "PWY-7656", "PWY-7726", "R-RNO-1482798", "R-RNO-77352", "R-MMU-9837999", "R-RNO-77346", "R-CEL-77348", "R-HSA-77288", "R-DRE-390247", "R-CEL-77350", "R-DDI-70895", "R-RNO-77310", "R-HSA-77350", "R-HSA-77285", "R-HSA-77346", "R-MMU-77352", "R-SSC-77346", "R-RNO-77305", "R-RNO-9033241", "R-SSC-77310", "R-MMU-77346", "R-RNO-77350", "R-RNO-77285", "R-RNO-77288", "R-MMU-70895", "R-CEL-70895", "R-MMU-77310", "R-SCE-9033241", "R-RNO-77348", "R-BTA-77352", "R-MMU-1482798", "R-HSA-77305", "R-HSA-9837999", "R-SSC-77305", "R-HSA-77352", "R-DDI-9033241", "R-CEL-77346", "R-DDI-9837999", "R-SSC-77348", "R-BTA-70895", "R-HSA-9914274", "R-HSA-9916720", "R-SSC-77350", "R-CEL-77352", "R-MMU-77350", "R-SCE-390247", "R-SSC-1482798", "R-BTA-77310", "R-HSA-70895", "R-MMU-9033241", "R-HSA-77348", "R-CEL-77310", "R-RNO-9837999", "R-DDI-77350", "R-HSA-1482798", "R-DDI-77346", "R-DDI-77348", "R-DDI-77310", "R-RNO-70895", "R-BTA-77348", "R-MMU-77348", "R-MMU-77285", "R-BTA-77350", "R-MMU-77305", "R-HSA-77310", "R-BTA-77346", "R-SSC-77285", "R-HSA-390247", "R-MMU-390247", "R-DDI-77352", "R-MMU-77288", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-6458:t:benzoyl-CoA biosynthesis", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-8354:t:adipate degradation", "PWY-8347:t:adipate biosynthesis", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-5138:t:fatty acid beta-oxidation IV (unsaturated, even number)", "PWY-6446:t:benzoate biosynthesis III (CoA-dependent, non-beta-oxidative)", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "PWY-1361:t:benzoyl-CoA degradation I (aerobic)", "PWY-6443:t:benzoate biosynthesis I (CoA-dependent, beta-oxidative)", "PWY-8179:t:platensimycin biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "R-RNO-1482798:r:Acyl chain remodeling of CL", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DRE-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SSC-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-RNO-9033241:r:Peroxisomal protein import", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-RNO-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-SCE-9033241:r:Peroxisomal protein import", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-DDI-9033241:r:Peroxisomal protein import", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-SSC-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9914274:r:3-methylglutaconic aciduria", "R-HSA-9916720:r:Mitochondrial short-chain enoyl-CoA hydratase deficiency 1", "R-SSC-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-CEL-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-SSC-1482798:r:Acyl chain remodeling of CL", "R-BTA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-CEL-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DDI-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-DDI-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-DDI-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR001754": {"description": "Orotidine 5'-phosphate decarboxylase domain", "go_ids": ["GO:0004590", "GO:0006207"], "go_terms": ["GO:0004590:orotidine-5'-phosphate decarboxylase activity:F", "GO:0006207:'de novo' pyrimidine nucleobase biosynthetic process:P"], "name": "OMPdeCOase_dom", "pathway_ids": ["PWY-5686", "PWY-7790", "R-MMU-500753", "R-CEL-500753", "R-DME-500753", "R-DDI-500753", "R-HSA-500753", "PWY-7791"], "pathways": ["PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "R-MMU-500753:r:Pyrimidine biosynthesis", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-DME-500753:r:Pyrimidine biosynthesis", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-HSA-500753:r:Pyrimidine biosynthesis", "PWY-7791:t:UMP biosynthesis III"], "type": "Domain"}, "IPR001757": {"description": "P-type ATPase", "go_ids": ["GO:0016887", "GO:0005524", "GO:0005215", "GO:0016020"], "go_terms": ["GO:0016887:ATP hydrolysis activity:F", "GO:0005524:ATP binding:F", "GO:0005215:transporter activity:F", "GO:0016020:membrane:C"], "name": "P_typ_ATPase", "pathway_ids": ["R-HSA-6798695", "R-GGA-936837", "R-SPO-6798695", "R-RNO-6803544", "R-HSA-6803544", "R-DRE-936837", "R-XTR-936837", "R-CEL-6798695", "R-SCE-6798695", "R-DME-418359", "R-DDI-5578775", "R-BTA-936837", "R-SSC-936837", "R-CFA-936837", "R-MMU-418359", "R-HSA-9662360", "R-BTA-5578775", "R-CFA-5578775", "R-HSA-5578775", "R-MMU-6803544", "R-MMU-936837", "R-CFA-418359", "R-SPO-5578775", "R-DDI-418359", "R-CEL-936837", "R-SCE-418359", "R-DDI-936837", "R-HSA-418359", "R-HSA-1912420", "R-CEL-418359", "R-HSA-3299685", "R-GGA-418359", "R-DME-936837", "R-GGA-5578775", "R-DME-5578775", "R-RNO-5578775", "R-HSA-9662361", "R-RNO-418359", "R-SPO-418359", "R-MMU-5578775", "R-SPO-936837", "R-HSA-936837", "R-HSA-9679191", "R-SSC-5578775", "R-RNO-936837", "R-SCE-936837", "R-SCE-5578775", "R-CEL-5578775", "R-MMU-6798695", "R-SSC-418359", "R-BTA-418359"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-936837:r:Ion transport by P-type ATPases", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-DRE-936837:r:Ion transport by P-type ATPases", "R-XTR-936837:r:Ion transport by P-type ATPases", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-418359:r:Reduction of cytosolic Ca++ levels", "R-DDI-5578775:r:Ion homeostasis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-SSC-936837:r:Ion transport by P-type ATPases", "R-CFA-936837:r:Ion transport by P-type ATPases", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-5578775:r:Ion homeostasis", "R-CFA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-6803544:r:Ion influx/efflux at host-pathogen interface", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CFA-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-5578775:r:Ion homeostasis", "R-DDI-418359:r:Reduction of cytosolic Ca++ levels", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-SCE-418359:r:Reduction of cytosolic Ca++ levels", "R-DDI-936837:r:Ion transport by P-type ATPases", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-CEL-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-GGA-418359:r:Reduction of cytosolic Ca++ levels", "R-DME-936837:r:Ion transport by P-type ATPases", "R-GGA-5578775:r:Ion homeostasis", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-5578775:r:Ion homeostasis", "R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SSC-5578775:r:Ion homeostasis", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases", "R-SCE-5578775:r:Ion homeostasis", "R-CEL-5578775:r:Ion homeostasis", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-418359:r:Reduction of cytosolic Ca++ levels", "R-BTA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Family"}, "IPR001759": {"description": "Pentraxin domain", "go_ids": [], "go_terms": [], "name": "PTX_dom", "pathway_ids": ["R-HSA-6798695", "R-DRE-9619665", "R-HSA-173623", "R-RNO-173623", "R-HSA-977225", "R-SSC-173623", "R-MMU-6798695", "R-HSA-9619665", "R-MMU-9619665", "R-MMU-173623"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-HSA-977225:r:Amyloid fiber formation", "R-SSC-173623:r:Classical antibody-mediated complement activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-173623:r:Classical antibody-mediated complement activation"], "type": "Domain"}, "IPR001761": {"description": "Periplasmic binding protein/LacI sugar binding domain", "go_ids": [], "go_terms": [], "name": "Peripla_BP/Lac1_sug-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001762": {"description": "Disintegrin domain", "go_ids": [], "go_terms": [], "name": "Disintegrin_dom", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-SSC-6798695", "R-HSA-2122948", "R-HSA-9662834", "R-RNO-1474228", "R-CEL-6798695", "R-HSA-977225", "R-HSA-1251985", "R-BTA-6798695", "R-HSA-75893", "R-SSC-1474228", "R-RNO-193692", "R-SPO-8941237", "R-MMU-8957275", "R-BTA-8957275", "R-MMU-193692", "R-CEL-1474228", "R-HSA-2979096", "R-HSA-5362798", "R-HSA-9013700", "R-MMU-9013507", "R-MMU-8941237", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-RNO-8957275", "R-HSA-177929", "R-BTA-381426", "R-RNO-75893", "R-HSA-9013507", "R-HSA-2691232", "R-HSA-381426", "R-HSA-1442490", "R-MMU-1474228", "R-RNO-8941237", "R-HSA-1474228", "R-MMU-2534343", "R-MMU-75893", "R-SSC-381426", "R-SSC-8957275", "R-BTA-1474228", "R-HSA-2894862", "R-RNO-9013507", "R-MMU-9762292", "R-HSA-982772", "R-RNO-381426", "R-HSA-2534343", "R-HSA-2660826", "R-HSA-3928665", "R-HSA-8941237", "R-MMU-5682910", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-8957275", "R-HSA-2644606", "R-HSA-5682910", "R-HSA-193692", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-75893:r:TNF signaling", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-SPO-8941237:r:Invadopodia formation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-8941237:r:Invadopodia formation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-177929:r:Signaling by EGFR", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-75893:r:TNF signaling", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-RNO-8941237:r:Invadopodia formation", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-MMU-75893:r:TNF signaling", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8941237:r:Invadopodia formation", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR001763": {"description": "Rhodanese-like domain", "go_ids": [], "go_terms": [], "name": "Rhodanese-like_dom", "pathway_ids": ["R-DME-69273", "R-DDI-156711", "R-BTA-5689880", "R-HSA-5689880", "R-SSC-176187", "R-DDI-6804115", "R-MMU-75035", "R-MMU-380320", "R-BTA-69202", "R-MMU-5689880", "R-DME-947581", "R-HSA-69656", "R-MMU-112409", "R-BTA-2565942", "R-BTA-69601", "R-SPO-6804115", "R-CEL-112409", "R-RNO-380284", "R-SSC-947581", "R-SSC-5625740", "R-MMU-5620912", "R-BTA-5625740", "R-SPO-176187", "R-GGA-437980", "R-HSA-202670", "R-DME-69202", "R-SCE-6804115", "R-MMU-380259", "R-DME-156711", "R-MMU-380270", "R-DRE-380320", "R-RNO-5675221", "R-XTR-380320", "R-RNO-5689880", "R-RNO-202670", "R-BTA-5675221", "R-DME-5675221", "R-MMU-69656", "R-HSA-112409", "R-HSA-6804114", "R-DME-69601", "R-MMU-69273", "R-DDI-69202", "R-RNO-380270", "R-MMU-5675221", "R-SCE-69601", "R-HSA-8862803", "R-HSA-5625740", "R-RNO-69601", "R-MMU-380284", "R-DME-5625740", "R-SPO-5625740", "R-HSA-947581", "R-MMU-69202", "R-CEL-69656", "R-HSA-75035", "R-RNO-2565942", "R-SPO-69656", "R-DDI-69601", "R-BTA-380320", "R-DDI-112409", "R-SCE-176187", "R-MMU-202670", "R-HSA-176187", "R-DDI-5689880", "R-SCE-5625740", "R-DME-176187", "R-CEL-69273", "R-HSA-4641263", "R-HSA-156711", "R-MMU-947581", "R-RNO-1614558", "R-HSA-6807004", "R-HSA-380270", "R-HSA-1358803", "R-HSA-9636569", "R-DDI-947581", "R-BTA-6804115", "R-RNO-69273", "R-DDI-5675221", "R-RNO-380259", "R-CEL-5689880", "R-MMU-6807004", "R-DME-75035", "R-SCE-156711", "R-XTR-8854518", "R-DME-5689880", "R-DME-69656", "R-BTA-947581", "R-SCE-75035", "R-CEL-176187", "R-HSA-6804115", "R-MMU-4641263", "R-BTA-202670", "R-SSC-75035", "R-HSA-69273", "R-HSA-380284", "R-RNO-176187", "R-MMU-5625740", "R-BTA-75035", "R-GGA-437986", "R-HSA-8854518", "R-MMU-2565942", "R-BTA-380259", "R-CEL-947581", "R-RNO-380320", "R-SPO-947581", "R-HSA-380320", "R-SSC-156711", "R-BTA-5620912", "R-BTA-156711", "R-SCE-1614558", "R-HSA-9825892", "R-DME-112409", "R-RNO-199418", "R-SSC-6804115", "R-DDI-69656", "R-SPO-1614558", "R-DME-202670", "R-XTR-380259", "R-SPO-69202", "R-MMU-1614558", "R-DRE-947581", "R-HSA-1362277", "R-MMU-176187", "R-DDI-5625740", "R-SPO-75035", "R-MMU-8854518", "R-MMU-6804115", 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proteinase activated receptors (PARs)", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CFA-418594:r:G alpha (i) signalling events", "R-CFA-416476:r:G alpha (q) signalling events", "R-HSA-418597:r:G alpha (z) signalling events", "R-CEL-418597:r:G alpha (z) signalling events", "R-MMU-392170:r:ADP signalling through P2Y purinoceptor 12", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-9634597:r:GPER1 signaling", "R-CFA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-418597:r:G alpha (z) signalling events", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-418594:r:G alpha (i) signalling events", "R-CFA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-418594:r:G alpha (i) signalling events", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-4086398:r:Ca2+ pathway", "R-MMU-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-CFA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-CEL-2485179:r:Activation of the phototransduction cascade", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-BTA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DME-418594:r:G alpha (i) signalling events", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-392170:r:ADP signalling through P2Y purinoceptor 12", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-MMU-418555:r:G alpha (s) signalling events", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-RNO-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-418597:r:G alpha (z) signalling events", "R-DME-428930:r:Thromboxane signalling through TP receptor", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-BTA-420092:r:Glucagon-type ligand receptors", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-202040:r:G-protein activation"], "type": "Family"}, "IPR001772": {"description": "Kinase associated domain 1 (KA1)", "go_ids": [], "go_terms": [], "name": "KA1_dom", "pathway_ids": ["R-MMU-9856649", "R-RNO-5673000", "R-DDI-5628897", "R-DDI-1632852", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-6802952", "R-SPO-5628897", "R-RNO-9856649", "R-SPO-380972", "R-CEL-5675221", "R-MMU-5673000", "R-CEL-5673000", "R-DDI-380972", "R-RNO-5675221", "R-CEL-5674135", "R-DDI-200425", "R-DDI-5675221", "R-DDI-163680", "R-SCE-1632852", "R-HSA-5673000", "R-DDI-5674135", "R-SCE-380972", "R-HSA-6802946", "R-HSA-9649948", "R-DDI-5673000", "R-HSA-9856649", "R-RNO-5674135", "R-CEL-9856649", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-6802955", "R-SPO-1632852", "R-MMU-5675221", "R-HSA-9656223", "R-HSA-5675221"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-5673000:r:RAF activation", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-1632852:r:Macroautophagy", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-MMU-5673000:r:RAF activation", "R-CEL-5673000:r:RAF activation", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-DDI-200425:r:Carnitine shuttle", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DDI-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-SCE-1632852:r:Macroautophagy", "R-HSA-5673000:r:RAF activation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-DDI-5673000:r:RAF activation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SPO-1632852:r:Macroautophagy", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR001774": {"description": "Delta/Serrate/lag-2 (DSL) protein", "go_ids": ["GO:0007154", "GO:0016020"], "go_terms": ["GO:0007154:cell communication:P", "GO:0016020:membrane:C"], "name": "DSL", "pathway_ids": ["R-HSA-9022702", "R-HSA-8941856", "R-HSA-9725554", "R-HSA-2122948", "R-MMU-2122948", "R-RNO-9013149", "R-HSA-9824272", "R-HSA-9013423", "R-HSA-2979096", "R-HSA-9013700", "R-MMU-9013507", "R-DRE-9013149", "R-HSA-2691232", "R-HSA-9013507", "R-DME-2979096", "R-DME-9013149", "R-DRE-2979096", "R-HSA-2894862", "R-RNO-9013507", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-2660826", "R-HSA-9793380", "R-HSA-9831926", "R-HSA-2644606", "R-MMU-9013149", "R-DME-9013423", "R-DRE-9013423"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9824272:r:Somitogenesis", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-9831926:r:Nephron development", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR001780": {"description": "Large ribosomal subunit protein eL33", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL33", "pathway_ids": ["R-DDI-975956", "R-HSA-9954716", "R-BTA-975957", "R-CEL-975957", "R-MMU-72689", "R-SCE-72706", "R-HSA-9010553", "R-SPO-9954714", "R-SCE-9954709", "R-HSA-156827", "R-SPO-975957", "R-MMU-9954709", "R-BTA-72689", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-SPO-72689", "R-MMU-9954716", "R-CEL-975956", "R-BTA-72706", "R-SCE-975957", "R-DDI-9954714", "R-HSA-9954709", "R-DDI-9954716", "R-CEL-72706", "R-SCE-1799339", "R-SPO-1799339", "R-DDI-9954709", "R-CEL-9954714", "R-SCE-72689", "R-CEL-9954716", "R-MMU-975956", "R-SPO-9954709", "R-HSA-1799339", "R-MMU-6791226", "R-SCE-156827", "R-HSA-2408557", "R-BTA-156827", "R-HSA-9633012", "R-MMU-9954714", "R-CEL-9954709", "R-BTA-9954716", "R-BTA-6791226", "R-SPO-975956", "R-SCE-975956", "R-CEL-1799339", "R-MMU-975957", "R-SPO-72706", "R-HSA-156902", "R-HSA-72706", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-CEL-156827", "R-BTA-9954714", "R-HSA-975957", "R-HSA-6791226", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-156827", "R-HSA-9954714", "R-DDI-156827", "R-CEL-72689", "R-DDI-72689", "R-MMU-1799339"], "pathways": ["R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-192823:r:Viral mRNA Translation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR001781": {"description": "Zinc finger, LIM-type", "go_ids": [], "go_terms": [], "name": "Znf_LIM", "pathway_ids": ["R-RNO-5627123", "R-HSA-1989781", "R-MMU-446353", "R-BTA-446353", "R-BTA-9841922", "R-HSA-180292", "R-HSA-8951664", "R-BTA-1234176", "R-HSA-9010553", "R-RNO-446388", "R-DDI-446353", "R-GGA-2029482", "R-MMU-445355", "R-MMU-4420097", "R-DRE-8939236", "R-MMU-446388", "R-MMU-2565942", "R-DME-350376", "R-HSA-3928662", "R-HSA-9841922", "R-HSA-8849471", "R-HSA-4420097", "R-RNO-399954", "R-CEL-446343", "R-DME-2029482", "R-DME-350411", "R-BTA-2565942", "R-SCE-8980692", "R-SCE-9013149", "R-HSA-446343", "R-HSA-9926550", "R-MMU-399954", "R-BTA-8853659", "R-DME-399954", "R-HSA-8853659", "R-DME-4608870", "R-MMU-8849471", "R-RNO-446343", "R-HSA-1234176", "R-XTR-4608870", "R-DME-350369", "R-DDI-983231", "R-MMU-180292", "R-RNO-8853659", "R-HSA-9830364", "R-DME-5627123", "R-MMU-8853659", "R-HSA-983231", "R-DRE-1234176", "R-HSA-2029482", "R-SPO-9013148", "R-CEL-446353", "R-MMU-1234176", "R-RNO-8939236", "R-SPO-8980692", "R-SCE-9013148", "R-SCE-9035034", "R-HSA-4608870", "R-HSA-5683826", "R-HSA-399954", "R-SPO-9013424", "R-CEL-446388", "R-RNO-9841922", "R-MMU-5627123", "R-DME-1234176", "R-HSA-5617472", "R-RNO-4420097", "R-RNO-1234176", "R-SPO-6798695", "R-DDI-446388", "R-HSA-9752946", "R-SCE-9013423", "R-HSA-5660489", "R-HSA-416572", "R-GGA-399954", "R-SCE-6798695", "R-DDI-8849471", "R-DME-350368", "R-HSA-418885", "R-XTR-8939236", "R-RNO-2029482", "R-HSA-6794361", "R-MMU-8939236", "R-GGA-5627123", "R-HSA-2565942", "R-RNO-2565942", "R-RNO-445355", "R-SCE-9013424", "R-MMU-446343", "R-MMU-4608870", "R-DME-450728", "R-MMU-5683826", "R-HSA-400511", "R-BTA-8939236", "R-RNO-8849471", "R-RNO-4608870", "R-HSA-445355", "R-DME-350480", "R-HSA-983168", "R-RNO-180292", 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ribosome-associated quality control", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-5419276:r:Mitochondrial translation termination", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR001791": {"description": "Laminin G domain", "go_ids": [], "go_terms": [], "name": "Laminin_G", "pathway_ids": ["R-RNO-2022923", "R-HSA-8874081", "R-RNO-2022090", "R-HSA-3560783", "R-HSA-3000178", "R-HSA-9010553", "R-HSA-140837", "R-HSA-9918485", "R-RNO-140875", "R-DME-1912420", "R-HSA-3656237", "R-HSA-9856532", "R-RNO-140837", "R-MMU-975634", "R-DME-390150", "R-DME-350411", "R-MMU-202733", "R-HSA-8948216", "R-HSA-446107", "R-DME-390023", "R-HSA-1474228", "R-RNO-1566977", "R-HSA-2022870", "R-MMU-1592389", "R-DRE-2979096", "R-RNO-8948216", "R-HSA-3000171", "R-HSA-1971475", "R-RNO-159763", "R-HSA-373752", "R-DME-6809371", "R-HSA-419037", "R-HSA-9820960", "R-HSA-159740", "R-MMU-376176", "R-HSA-2022090", "R-HSA-2022923", "R-CEL-376176", "R-MMU-5173214", "R-MMU-216083", "R-MMU-2024101", "R-DME-9013700", "R-MMU-186797", "R-DME-9010553", "R-RNO-216083", "R-HSA-3595172", "R-BTA-159782", "R-HSA-373760", "R-RNO-8874081", "R-HSA-114608", "R-CEL-9010553", "R-HSA-9638630", "R-MMU-8874081", "R-MMU-159763", "R-HSA-3595177", "R-MMU-2022928", "R-HSA-2022928", "R-RNO-2022870", "R-DME-376176", "R-HSA-1442490", "R-HSA-159763", "R-CEL-9013423", "R-HSA-9925563", "R-RNO-1650814", "R-MMU-3000157", "R-BTA-140875", "R-MMU-1566977", "R-HSA-8985801", "R-HSA-3000170", "R-DME-6798695", "R-HSA-376176", "R-HSA-9913351", "R-DRE-6794361", "R-DME-446107", "R-DME-350480", "R-HSA-140875", "R-DME-351906", "R-MMU-2022090", "R-MMU-140875", "R-MMU-1650814", "R-MMU-159782", "R-RNO-2022928", "R-HSA-428540", "R-HSA-428890", "R-RNO-419037", "R-HSA-202733", "R-HSA-975634", "R-HSA-3595174", "R-HSA-186797", "R-DME-9604323", "R-HSA-159782", "R-BTA-140837", "R-MMU-159740", "R-MMU-2024096", "R-CEL-6798695", "R-MMU-8957275", "R-DME-350376", "R-HSA-1650814", "R-RNO-2024096", "R-MMU-3000171", "R-MMU-3000178", "R-RNO-202733", "R-MMU-381426", "R-RNO-3000178", "R-RNO-159740", "R-MMU-2022923", "R-HSA-381426", "R-RNO-3000171", "R-HSA-447043", "R-HSA-2024101", "R-MMU-140837", "R-HSA-9694614", "R-HSA-6785807", "R-HSA-3560801", "R-RNO-381426", "R-MMU-9913351", "R-HSA-4420332", "R-CEL-6809371", "R-RNO-6794361", "R-BTA-159763", "R-MMU-114608", "R-MMU-419037", "R-DME-350379", "R-MMU-2022870", "R-HSA-9725554", "R-HSA-3000157", "R-MMU-8948216", "R-HSA-977225", "R-RNO-159782", "R-HSA-9619665", "R-MMU-9010553", "R-DME-350368", "R-RNO-114608", "R-HSA-6794361", "R-BTA-202733", "R-BTA-114608", "R-HSA-3656253", "R-HSA-977606", "R-RNO-8957275", "R-RNO-2024101", "R-HSA-2024096", "R-HSA-9833110", "R-RNO-975634", "R-DME-428890", "R-HSA-9918481", "R-DME-450728", "R-BTA-159740", "R-HSA-2214320", "R-HSA-216083", "R-HSA-428542", "R-MMU-6794361", "R-HSA-1566977", "R-MMU-428890", "R-RNO-186797", "R-MMU-8985586", "R-RNO-1442490", "R-RNO-9913351", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-RNO-1971475", "R-HSA-8957275", "R-MMU-1971475", "R-MMU-1442490", "R-DME-9013423"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-DME-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-975634:r:Retinoid metabolism and transport", "R-DME-390150:r:DS ligand bound to FT receptor", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-8948216:r:Collagen chain trimerization", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-DME-390023:r:Subcellular localisation of D", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-1566977:r:Fibronectin matrix formation", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-DRE-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-8948216:r:Collagen chain trimerization", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-373752:r:Netrin-1 signaling", "R-DME-6809371:r:Formation of the cornified envelope", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-CEL-376176:r:Signaling by ROBO receptors", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-2024101:r:CS/DS degradation", "R-DME-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-186797:r:Signaling by PDGF", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-BTA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-373760:r:L1CAM interactions", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-DME-376176:r:Signaling by ROBO receptors", "R-HSA-1442490:r:Collagen degradation", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-3000157:r:Laminin interactions", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-1566977:r:Fibronectin matrix formation", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-HSA-3000170:r:Syndecan interactions", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DRE-6794361:r:Neurexins and neuroligins", "R-DME-446107:r:Type I hemidesmosome assembly", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-HSA-428540:r:Activation of RAC1", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-419037:r:NCAM1 interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-HSA-186797:r:Signaling by PDGF", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-2024096:r:HS-GAG degradation", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-2024096:r:HS-GAG degradation", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-2024101:r:CS/DS degradation", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-CEL-6809371:r:Formation of the cornified envelope", "R-RNO-6794361:r:Neurexins and neuroligins", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-114608:r:Platelet degranulation", "R-MMU-419037:r:NCAM1 interactions", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-RNO-114608:r:Platelet degranulation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-BTA-114608:r:Platelet degranulation", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-2024096:r:HS-GAG degradation", "R-HSA-9833110:r:RSV-host interactions", "R-RNO-975634:r:Retinoid metabolism and transport", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-450728:r:Inhibition of actin polymerization", "R-BTA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-1566977:r:Fibronectin matrix formation", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-RNO-1442490:r:Collagen degradation", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-1442490:r:Collagen degradation", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR001792": {"description": "Acylphosphatase-like domain", "go_ids": [], "go_terms": [], "name": "Acylphosphatase-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001795": {"description": "RNA-directed RNA polymerase, Orthornavirae", "go_ids": ["GO:0003723", "GO:0003968", "GO:0006351"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "RNA-dir_pol_orthornavirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001796": {"description": "Dihydrofolate reductase domain", "go_ids": ["GO:0004146", "GO:0046654"], "go_terms": ["GO:0004146:dihydrofolate reductase activity:F", "GO:0046654:tetrahydrofolate biosynthetic process:P"], "name": "DHFR_dom", "pathway_ids": ["PWY-6614", "PWY-3841", "R-DME-196757", "R-HSA-69205", "R-HSA-1474151", "R-MMU-196757", "R-RNO-196757", "R-SCE-196757", "R-SPO-196757", "R-HSA-196757", "R-CEL-196757"], "pathways": ["PWY-6614:t:tetrahydrofolate biosynthesis I", "PWY-3841:t:folate transformations II (plants)", "R-DME-196757:r:Metabolism of folate and pterines", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-196757:r:Metabolism of folate and pterines", "R-RNO-196757:r:Metabolism of folate and pterines", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Domain"}, "IPR001799": {"description": "Ephrin receptor-binding domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Ephrin_RBD", "pathway_ids": ["R-CEL-3928664", "R-HSA-3928664", "R-MMU-3928665", "R-DRE-3928662", "R-RNO-2682334", "R-MMU-2682334", "R-MMU-3928663", "R-RNO-3928663", "R-RNO-3928664", "R-HSA-3928662", "R-CEL-3928665", "R-DRE-3928664", "R-BTA-3928663", "R-HSA-3928663", "R-CEL-3928663", "R-HSA-3928665", "R-CEL-2682334", "R-RNO-3928665", "R-MMU-3928662", "R-RNO-3928662", "R-BTA-2682334", "R-HSA-2682334", "R-DRE-3928665", "R-DRE-3928663", "R-CEL-3928662", "R-BTA-3928665", "R-MMU-3928664", "R-DRE-2682334"], "pathways": ["R-CEL-3928664:r:Ephrin signaling", "R-HSA-3928664:r:Ephrin signaling", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928664:r:Ephrin signaling", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-BTA-2682334:r:EPH-Ephrin signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-3928664:r:Ephrin signaling", "R-DRE-2682334:r:EPH-Ephrin signaling"], "type": "Domain"}, "IPR001800": {"description": "Lipoprotein, OspC-type", "go_ids": ["GO:0009279"], "go_terms": ["GO:0009279:cell outer membrane:C"], "name": "Lipoprotein_OspC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001801": {"description": "DNA-binding protein H-NS-like", "go_ids": ["GO:0003677", "GO:0006355", "GO:0030527"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0030527:structural constituent of chromatin:F"], "name": "Histone_HNS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001803": {"description": "Orbivirus inner capsid protein VP7", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Orbi_VP7_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001805": {"description": "Adenosine kinase", "go_ids": ["GO:0004001", "GO:0006166"], "go_terms": ["GO:0004001:adenosine kinase activity:F", "GO:0006166:purine ribonucleoside salvage:P"], "name": "Adenokinase", "pathway_ids": ["PWY-6619", "R-MMU-9755088", "R-SCE-74217", "R-DDI-9755088", "R-DDI-74217", "R-SCE-9755088", "R-RNO-9755088", "R-RNO-74217", "R-MMU-74217", "R-SPO-9755088", "R-HSA-74217", "R-HSA-9755088", "R-SPO-74217"], "pathways": ["PWY-6619:t:adenine and adenosine salvage VI", "R-MMU-9755088:r:Ribavirin ADME", "R-SCE-74217:r:Purine salvage", "R-DDI-9755088:r:Ribavirin ADME", "R-DDI-74217:r:Purine salvage", "R-SCE-9755088:r:Ribavirin ADME", "R-RNO-9755088:r:Ribavirin ADME", "R-RNO-74217:r:Purine salvage", "R-MMU-74217:r:Purine salvage", "R-SPO-9755088:r:Ribavirin ADME", "R-HSA-74217:r:Purine salvage", "R-HSA-9755088:r:Ribavirin ADME", "R-SPO-74217:r:Purine salvage"], "type": "Family"}, "IPR001806": {"description": "Small GTPase", "go_ids": ["GO:0005525", "GO:0003924"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0003924:GTPase activity:F"], "name": "Small_GTPase", "pathway_ids": ["R-HSA-9665686", "R-GGA-8876198", "R-CEL-8985586", "R-GGA-5621575", "R-RNO-8964616", "R-DME-5687128", "R-MMU-8875555", "R-BTA-193634", "R-SSC-212676", "R-CFA-9013106", "R-HSA-381676", "R-SPO-9013424", "R-BTA-114604", "R-RNO-8875555", "R-MMU-5654688", "R-RNO-5689896", "R-RNO-181429", "R-BTA-9013106", "R-MMU-375165", "R-GGA-5654719", "R-MMU-1169092", "R-DME-392451", "R-DME-1810476", "R-SCE-5627123", "R-CFA-204005", "R-RNO-5620912", "R-DDI-9013149", "R-HSA-9032759", "R-DDI-381676", "R-CEL-8876198", "R-HSA-6802946", "R-CFA-6785631", "R-DME-8856828", "R-GGA-180336", "R-GGA-933542", "R-RNO-9013106", "R-BTA-8849471", "R-DME-381676", "R-SSC-5658442", "R-MMU-5654719", "R-DRE-392451", "R-DME-9013407", "R-DME-8854214", "R-GGA-6811436", "R-RNO-6811434", "R-HSA-5627083", "R-CEL-392517", "R-SPO-9013425", "R-HSA-6807878", "R-CFA-416550", "R-MMU-3928663", "R-SCE-8854214", "R-BTA-5625900", "R-CFA-5689896", "R-CEL-180336", "R-CFA-114604", "R-RNO-5625900", "R-BTA-9013408", "R-RNO-5218921", "R-DRE-9607240", "R-SCE-9013419", "R-SSC-8851805", "R-SSC-5654688", "R-DRE-193634", "R-RNO-186763", "R-HSA-9696273", "R-CEL-5654704", "R-DRE-3928663", "R-RNO-9013026", "R-BTA-5689880", "R-MMU-3928665", "R-HSA-2871796", "R-MMU-181430", "R-MMU-933542", "R-SPO-5578749", "R-SCE-8980692", "R-HSA-9662360", "R-BTA-6811558", "R-CEL-9639288", "R-RNO-375165", "R-HSA-6802955", "R-SCE-9696273", "R-MMU-9013419", "R-DDI-6798695", "R-BTA-5627117", "R-CFA-9013148", "R-HSA-6802948", "R-DDI-983231", "R-RNO-5675221", "R-SCE-193648", "R-CFA-3928662", "R-GGA-9607240", "R-HSA-5654700", "R-CEL-1433557", "R-MMU-179812", "R-SSC-9013149", "R-DDI-9013418", "R-RNO-5654699", "R-MMU-5674135", "R-BTA-4086400", "R-BTA-5620916", "R-CFA-9013424", "R-HSA-5578749", "R-CFA-8876198", "R-CEL-210500", "R-RNO-5627083", "R-GGA-1963640", "R-SSC-1169092", "R-HSA-114608", "R-CFA-8849471", "R-CFA-418885", "R-RNO-5666185", "R-CFA-9696264", "R-CEL-5625900", "R-RNO-354192", "R-HSA-9013148", "R-RNO-5674135", "R-HSA-6811436", "R-DDI-5628897", "R-RNO-2132295", "R-GGA-9648002", "R-BTA-5666185", "R-HSA-9696270", "R-SPO-204005", "R-SSC-4420097", "R-BTA-418885", "R-HSA-180336", "R-BTA-416482", "R-RNO-9013423", "R-DME-5654712", "R-HSA-193634", "R-SSC-9648002", "R-CEL-179812", "R-HSA-187706", "R-HSA-3928665", "R-MMU-9032759", "R-BTA-181429", "R-DME-186763", "R-MMU-9696273", "R-HSA-5625970", "R-HSA-5668599", "R-DME-9639288", "R-HSA-6798695", "R-DDI-5218921", "R-CEL-210993", "R-HSA-8875555", "R-SSC-5675221", "R-MMU-2173791", "R-CEL-9013409", "R-GGA-2029482", "R-MMU-4420097", "R-HSA-5654693", "R-RNO-198203", "R-RNO-212676", "R-CFA-432040", "R-HSA-399955", "R-GGA-9013406", "R-DME-193634", "R-SSC-181430", 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"R-RNO-5218920", "R-DDI-389359", "R-RNO-399954", "R-BTA-4420097", "R-SPO-9696270", "R-MMU-1810476", "R-GGA-2179392", "R-GGA-5663220", "R-CFA-2132295", "R-DRE-416550", "R-MMU-186763", "R-CEL-389359", "R-CFA-6811440", "R-MMU-6811434", "R-DDI-9634635", "R-BTA-9013425", "R-GGA-375165", "R-DME-6785631", "R-CEL-5674135", "R-CEL-212676", "R-HSA-9820960", "R-DME-416572", "R-HSA-9748787", "R-CEL-8851805", "R-BTA-8875555", "R-MMU-170984", "R-BTA-8980692", "R-CEL-6811558", "R-MMU-9013418", "R-MMU-354192", "R-GGA-5673000", "R-GGA-9013424", "R-SCE-381676", "R-BTA-983231", "R-SPO-5625740", "R-MMU-8964616", "R-GGA-5627123", "R-BTA-416572", "R-RNO-416482", "R-RNO-389359", "R-MMU-2132295", "R-GGA-6811440", "R-RNO-3928662", "R-DRE-5625970", "R-BTA-8876198", "R-CFA-5666185", "R-DME-6811440", "R-HSA-5655332", "R-DME-5654719", "R-DRE-179812", "R-RNO-5626467", "R-CEL-380972", "R-DDI-5675221", "R-CFA-9696273", "R-RNO-9032759", "R-DRE-4420097", "R-HSA-180746", "R-CEL-114604", "R-DME-5689880", "R-DRE-5674135", "R-CEL-8980692", "R-HSA-5689896", "R-HSA-8856828", "R-SSC-9013408", "R-RNO-416572", "R-MMU-2565942", "R-CEL-5673001", "R-HSA-9013425", "R-DME-210993", "R-DRE-6798695", "R-RNO-170968", "R-MMU-399954", "R-DRE-5666185", "R-HSA-9673767", "R-GGA-3928662", "R-RNO-9748787", "R-DME-5673000", "R-CEL-525793", "R-GGA-8856828", "R-MMU-1433557", "R-MMU-5620916", "R-GGA-9013148", "R-MMU-5621575", "R-CEL-5628897", "R-SSC-9013406", "R-HSA-8876198", "R-RNO-5578749", "R-CFA-209563", "R-MMU-8876198", "R-MMU-9013406", "R-SCE-2029482", "R-SCE-445144", "R-RNO-9639288", "R-MMU-6798695", "R-CEL-186763", "R-BTA-354192", "R-SSC-9013148", "R-DRE-8851805", "R-MMU-114608", "R-SSC-5654699", "R-HSA-416550", "R-RNO-9674555", "R-CEL-392451", "R-CFA-8873719", "R-DDI-9615933", "R-MMU-6807878", "R-RNO-2029482", "R-GGA-186763", "R-RNO-5668599", "R-BTA-5674135", "R-CEL-5654706", "R-HSA-1222556", "R-HSA-1169092", "R-DME-166208", "R-DRE-5675221", "R-DME-9013406", "R-CFA-193634", "R-SSC-2029482", "R-CEL-181429", "R-DME-1250347", "R-HSA-432722", "R-HSA-380972", "R-DME-170968", "R-SCE-6807878", "R-HSA-2173791", "R-SPO-9013419", "R-HSA-5654706", "R-SSC-210500", "R-GGA-5663213", "R-HSA-9824585", "R-HSA-888590", "R-HSA-3928663", "R-HSA-5627123", "R-CEL-4420097", "R-MMU-416482", "R-CEL-8849471", "R-HSA-9664422", "R-DDI-1169092", "R-CFA-416482", "R-CEL-5218920", "R-HSA-5689880", "R-MMU-9013408", "R-MMU-210993", "R-HSA-9639288", "R-MMU-8854214", "R-CEL-888590", "R-GGA-5654706", "R-MMU-5663213", "R-BTA-5663213", "R-MMU-9013420", "R-RNO-983231", "R-MMU-1655829", "R-GGA-5658442", "R-GGA-9615933", "R-SSC-5654706", "R-MMU-5673001", "R-RNO-5673000", "R-BTA-5625740", "R-HSA-181430", "R-CFA-9013406", "R-HSA-182971", "R-CFA-8980692", "R-BTA-182971", "R-HSA-2424491", "R-RNO-5628897", "R-HSA-5637810", "R-GGA-5674135", "R-DME-9615933", "R-HSA-9615933", "R-DME-8951936", "R-SPO-5627123", "R-DME-162658", "R-RNO-9696264", "R-DME-1632852", "R-HSA-445144", "R-MMU-5627123", "R-GGA-5578749", "R-MMU-5675221", "R-MMU-416550", "R-HSA-5625900", "R-HSA-416572", "R-MMU-380972", "R-MMU-8980692", "R-SCE-162658", "R-DME-1433557", "R-HSA-9013423", "R-DME-392517", "R-HSA-203927", "R-CFA-6811558", "R-CEL-354192", "R-HSA-1250196", "R-SPO-9013420", "R-SPO-198203", "R-MMU-3928664", "R-BTA-8856828", "R-DDI-1632852", "R-GGA-9634635", "R-SSC-432040", "R-MMU-212676", "R-SCE-9696264", "R-DDI-166208", "R-SCE-8876198", "R-HSA-9726842", "R-MMU-1660499", "R-MMU-8943724", "R-GGA-5654712", "R-GGA-1250347", "R-SCE-392451", "R-CEL-198203", "R-HSA-8875656", "R-DME-5654706", "R-RNO-5627123", "R-DDI-354192", "R-CFA-4086400", "R-MMU-6785631", "R-BTA-9013424", "R-DME-8964616", "R-DME-4086400", "R-DME-933542", "R-HSA-8849471", "R-BTA-3928663", "R-SPO-9013106", "R-DME-2424491", "R-SSC-5663213", "R-GGA-5687128", "R-HSA-9649948", "R-SCE-9013420", "R-RNO-9013406", "R-CFA-5627117", "R-CEL-6785631", "R-CEL-9013148", "R-HSA-5655302", "R-XTR-392517", "R-MMU-193634", "R-MMU-5620924", "R-DDI-193648", "R-MMU-9748787", "R-RNO-5654693", "R-SCE-198203", "R-HSA-8950505", "R-MMU-5654700", "R-DME-2173791", "R-MMU-6811436", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-5658442", "R-DME-181430", "R-DRE-416482", "R-HSA-5654704", "R-SCE-392517", "R-DME-5625900", "R-CEL-375165", "R-CFA-5218920", "R-RNO-8943724", "R-SPO-5687128", "R-CEL-1632852", "R-SCE-8873719", "R-DME-350368", "R-CFA-9013404", "R-CEL-418885", "R-HSA-1236382", "R-SPO-9013409", "R-HSA-9619229", "R-DME-181429", "R-HSA-5620912", "R-BTA-1655829", "R-CFA-983231", "R-HSA-9028731", "R-HSA-354192", "R-MMU-5666185", "R-GGA-2871796", "R-HSA-193648", "R-RNO-1963640", "R-BTA-2173791", "R-HSA-8964616", "R-RNO-9634635", "R-CEL-6811436", "R-HSA-354194", "R-MMU-181429", "R-CFA-9013420", "R-DME-212676", "R-RNO-204005", "R-CEL-2029482", "R-HSA-5687128", "R-RNO-8873719", "R-DME-198203", "R-MMU-166208", "R-MMU-2424491", "R-DRE-5654688", "R-DME-4420097", "R-CFA-193648", "R-HSA-9013405", "R-SPO-416482", "R-DRE-5654699", "R-CFA-9013409", "R-MMU-180336", "R-RNO-5625970", "R-DDI-8873719", "R-BTA-3928662", "R-MMU-1632852", "R-DRE-1250347", "R-CFA-3928665", "R-HSA-9027284", "R-DDI-210500", "R-MMU-5689880", "R-HSA-432040", "R-CEL-182971", "R-CEL-1169092", "R-DME-5663213", "R-RNO-165159", "R-GGA-5673001", "R-DME-9607240", "R-DDI-204005", "R-MMU-9013407", "R-MMU-170968", "R-RNO-9824585", "R-BTA-381676", "R-DRE-1169092", "R-DDI-5673001", "R-DRE-186763", "R-HSA-373752", "R-DDI-6811438", "R-BTA-416550", "R-MMU-171007", "R-HSA-399954", "R-DRE-8854214", "R-BTA-6785631", "R-DRE-8980692", "R-RNO-5621575", "R-DME-165159", "R-DRE-198203", "R-HSA-179812", "R-SCE-983231", "R-RNO-9013420", "R-RNO-2871796", "R-BTA-1660499", "R-SSC-6798695", "R-DME-432553", "R-CEL-5687128", "R-SPO-9615933", "R-SSC-5626467", "R-CFA-5625740", "R-RNO-166208", "R-SCE-3928662", "R-HSA-166208", "R-RNO-2565942", "R-BTA-8985586", "R-DDI-8876198", "R-MMU-5654704", "R-GGA-9013408", "R-RNO-8856828", "R-GGA-9013149", "R-CFA-9696270", "R-DDI-9639288", "R-SSC-5654712", "R-DME-6798695", "R-DME-2179392", "R-GGA-392517", "R-MMU-9013424", "R-MMU-210500", "R-GGA-5654704", "R-RNO-3928664", "R-CFA-5620912", "R-SSC-5654693", "R-DRE-2173791", "R-DDI-162658", "R-BTA-6811438", "R-BTA-209563", "R-MMU-1222556", "R-SSC-5663220", "R-CEL-5626467", "R-CEL-6798695", "R-BTA-6798695", "R-HSA-9670439", "R-DME-380972", "R-DME-2029482", "R-MMU-445989", "R-MMU-5627117", "R-MMU-392451", "R-CEL-5654700", "R-CEL-8964616", "R-RNO-9013404", "R-HSA-9013408", "R-CEL-3928662", "R-CEL-5666185", "R-CEL-8854214", "R-GGA-445989", "R-DME-5674135", "R-HSA-3928664", "R-CFA-9032759", "R-RNO-3928663", "R-HSA-264642", "R-SSC-5654719", "R-GGA-9013423", "R-CEL-5627117", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-RNO-2173791", "R-HSA-204005", "R-DME-2871796", "R-CFA-399954", "R-DME-1655829", "R-DDI-5627123", "R-SSC-389359", "R-DRE-8875656", "R-HSA-1257604", "R-SCE-5687128", "R-DRE-5627117", "R-CEL-9013425", "R-DME-8943724", "R-DRE-1660499", "R-SPO-6798695", "R-HSA-2132295", "R-MMU-9648002", "R-HSA-74751", "R-DME-5654693", "R-RNO-9013419", "R-DME-525793", "R-BTA-5663220", "R-HSA-1250347", "R-BTA-5627123", "R-MMU-198203", "R-RNO-5663213", "R-HSA-9673770", "R-HSA-9636383", "R-DRE-8849471", "R-MMU-9824585", "R-HSA-9035034", "R-CFA-5620916", "R-DME-9013409", "R-SPO-8873719", "R-DDI-6811440", "R-CEL-6811438", "R-SCE-9013424", "R-HSA-8851805", "R-MMU-5218921", "R-SSC-2871796", "R-BTA-9013420", "R-RNO-5654706", "R-SSC-179812", "R-HSA-9706019", "R-CEL-5620912", "R-DME-8876198", "R-SSC-5654704", "R-SSC-2424491", "R-SPO-9035034", "R-HSA-9673324", "R-MMU-2029482", "R-CFA-5625900", "R-SSC-5673001", "R-DDI-8943724", "R-SCE-165159", "R-SSC-8856828", "R-RNO-2424491", "R-HSA-165159", "R-BTA-8854214", "R-RNO-5654700", "R-HSA-9013419", "R-HSA-5663213", "R-SSC-5673000", "R-BTA-9696273", "R-MMU-114604", "R-RNO-9607240", "R-CEL-5673000", "R-CEL-5621575", "R-DME-9634635", "R-MMU-9615933", "R-BTA-525793", "R-HSA-6811434", "R-MMU-8851805", "R-RNO-6811558", "R-CEL-165159", "R-DME-3928664", "R-SPO-389359", "R-GGA-9013420", "R-GGA-8875555", "R-MMU-5578749", "R-CFA-392451", "R-CFA-4420097", "R-MMU-4086400", "R-SSC-181429", "R-RNO-209563", "R-DME-5675221", "R-MMU-9013423", "R-HSA-5654699", "R-RNO-8875656", "R-RNO-8851805", "R-CFA-8875656", "R-CFA-198203", "R-DRE-8985586", "R-HSA-9648002", "R-SSC-1433557", "R-RNO-6798695", "R-HSA-9768919", "R-HSA-9656223", "R-BTA-2029482", "R-CFA-8985586", "R-CFA-2871796", "R-MMU-5654699", "R-DME-5578749", "R-BTA-8964616", "R-SPO-9013406", "R-HSA-181429", "R-DDI-9706019", "R-HSA-5620916", "R-SSC-9634635", "R-DME-5654699", "R-CEL-9013423", "R-SCE-9013409", "R-DDI-2029482", "R-HSA-1963640", "R-CFA-8856828", "R-SSC-5620916", "R-RNO-181430", "R-DDI-5663213", "R-DME-432722", "R-SPO-6811440", "R-SCE-9013106", "R-MMU-8873719", "R-CFA-6811434", "R-RNO-1660499", "R-BTA-9013404", "R-CEL-8873719", "R-SSC-983231", "R-BTA-1257604", "R-CEL-9013420", "R-CFA-6798695", "R-MMU-9013149", "R-GGA-372708", "R-CEL-983231", "R-MMU-182971", "R-HSA-5674135", "R-CFA-2424491", "R-DME-375165", "R-GGA-8849471", "R-DME-5621575", "R-CFA-162658", "R-DME-114604", "R-DRE-5654712", "R-CEL-9013424", "R-HSA-2179392", "R-GGA-354194", "R-HSA-9013424", "R-DDI-5626467", "R-DME-350376", "R-MMU-2871796", "R-MMU-9013422", "R-RNO-2179392", "R-SPO-9696273", "R-CFA-9013408", "R-DRE-1963640", "R-SSC-180336", "R-HSA-164944", "R-BTA-392517", "R-DME-5663220", "R-HSA-9664565", "R-CEL-264642", "R-DRE-5654706", "R-SPO-9696264", "R-CEL-9013419", "R-DME-210500", "R-XTR-8875555", "R-SSC-525793", "R-BTA-888590", "R-DRE-210993", "R-RNO-418885", "R-HSA-9013404", "R-SCE-9013148", "R-DME-445144", "R-CEL-5627123", "R-HSA-9703648", "R-RNO-264642", "R-RNO-380972", "R-DME-1963640", "R-HSA-372708", "R-DME-5628897", "R-SPO-5620912", "R-SSC-9696264", "R-RNO-6785631", "R-RNO-9696270", "R-MMU-432722", "R-HSA-418885", "R-RNO-354194", "R-DME-888590", "R-MMU-372708", "R-HSA-168333", "R-BTA-114608", "R-CFA-5668599", "R-CEL-5625740", "R-MMU-9013425", "R-DRE-5654693", "R-SSC-8849471", "R-DME-350407", "R-BTA-5689896", "R-GGA-5654699", "R-HSA-4086400", "R-MMU-8985586", "R-HSA-1433557", "R-MMU-209563", "R-CEL-381676", "R-HSA-1810476", "R-HSA-9703465", "R-HSA-428543", "R-GGA-8964616", "R-GGA-182971", "R-DRE-5654719", "R-MMU-9696270", "R-HSA-5675221", "R-MMU-8856828", "R-BTA-198203", "R-SSC-9607240", "R-SCE-204005", "R-GGA-1655829", "R-GGA-5675221", "R-CEL-9607240", "R-CEL-4086398", "R-MMU-8849471", "R-BTA-354194", "R-RNO-193648", "R-HSA-170984", "R-MMU-9035034", "R-SPO-2029482", "R-RNO-4086400", "R-SPO-8854214", "R-MMU-392517", "R-MMU-5625900", "R-MMU-5673000", "R-RNO-9013148", "R-RNO-5663220", "R-DRE-5673000", "R-CFA-9013407", "R-DRE-1655829", "R-DME-5218920", "R-DDI-5674135", "R-DME-193648", "R-DRE-9013026", "R-MMU-5654712", "R-MMU-9696264", "R-RNO-5654712", "R-HSA-392517", "R-HSA-9680350", "R-SSC-375165", "R-DME-180336", "R-DRE-3928662", "R-RNO-8980692", "R-RNO-1257604", "R-HSA-5625740", "R-BTA-5578749", "R-CEL-2179392", "R-DDI-6811434", "R-DDI-9013422", "R-GGA-5625970", "R-RNO-5654719", "R-SCE-5626467", "R-CEL-1655829", "R-CEL-9748787", "R-CEL-5654712", "R-CEL-9013406", "R-CEL-5620916", "R-CEL-171007", "R-RNO-8985586", "R-SSC-8876198", "R-GGA-1433557", "R-GGA-5218921", "R-CFA-1433557", "R-RNO-5627117", "R-HSA-1912420", "R-HSA-5666185", "R-GGA-5654700", "R-RNO-210500", "R-HSA-6785631", "R-HSA-9034864", "R-MMU-354194", "R-MMU-1257604", "R-DDI-9648002", "R-SCE-9696270", "R-DRE-375165", "R-HSA-170968", "R-HSA-428540", "R-SCE-389359", "R-RNO-432040", "R-MMU-1963640", "R-SCE-9615933", "R-BTA-8873719", "R-MMU-9013106", "R-SCE-416482", "R-MMU-5625740", "R-SSC-1250347", "R-HSA-9026519", "R-MMU-416572", "R-MMU-381676", "R-DRE-5673001", "R-CFA-1257604", "R-DDI-170968", "R-SSC-210993", "R-BTA-389359", "R-GGA-5654693", "R-RNO-162658", "R-MMU-162658", "R-BTA-5620912", "R-RNO-3928665", "R-HSA-8943724", "R-BTA-9013419", "R-DME-3928665", "R-DDI-9013423", "R-RNO-9013408", "R-RNO-5673001", "R-HSA-8951936", "R-RNO-179812", "R-DME-5654704", "R-SCE-6811434", "R-HSA-210993", "R-RNO-5620916", "R-BTA-5687128", "R-DME-3928662", "R-HSA-2029482", "R-DRE-354192", "R-HSA-5218921", "R-SPO-8980692", "R-DME-171007", "R-BTA-5668599", "R-BTA-9615933", "R-DRE-5654704", "R-CEL-1963640", "R-DRE-354194", "R-GGA-179812", "R-CEL-5689896", "R-BTA-210500", "R-HSA-167044", "R-DME-5654700", "R-DME-9013424", "R-MMU-983231", "R-HSA-6811440", "R-HSA-375165", "R-HSA-1660499", "R-DME-264642", "R-SSC-5625970", "R-HSA-5621575", "R-DME-983231", "R-CEL-5654699", "R-DME-9748787", "R-HSA-525793", "R-DME-450728", "R-BTA-392451", "R-CEL-5675221", "R-MMU-888590", "R-SSC-9013423", "R-RNO-381676", "R-SSC-9824585", "R-RNO-4086398", "R-DRE-9615933", "R-MMU-8875656", "R-RNO-182971", "R-HSA-392451", "R-MMU-418885", "R-HSA-9013409", "R-GGA-8854214", "R-DRE-9648002", "R-MMU-9674555", "R-MMU-4086398", "R-CFA-8964616", "R-DME-5218921", "R-HSA-442982", "R-SSC-5687128", "R-HSA-5673000", "R-HSA-5218920", "R-GGA-9013404", "R-DDI-5673000", "R-DRE-5663220", "R-MMU-5620912", "R-BTA-8875656", "R-DDI-445144", "R-HSA-210500", "R-SPO-5626467", "R-SPO-392451", "R-BTA-181430", "R-SSC-5654700", "R-RNO-210993", "R-RNO-445144", "R-HSA-416482", "R-CFA-445144", "R-SSC-114604", "R-SPO-9013148", "R-CEL-9648002", "R-HSA-9696264", "R-RNO-6811436", "R-RNO-5654688", "R-BTA-170984", "R-HSA-1445148", "R-MMU-193648", "R-HSA-9013026", "R-DME-182971", "R-CEL-170968", "R-HSA-212676", "R-DRE-9013419", "R-HSA-5655253", "R-HSA-6811438", "R-DME-5673001", "R-SSC-8964616", "R-HSA-8854214", "R-SSC-9013404", "R-DDI-165159", "R-GGA-162658", "R-SCE-6798695", "R-GGA-114604", "R-CFA-9035034", "R-BTA-9013406", "R-HSA-9013106", "R-HSA-2428933", "R-DME-9013425", "R-CFA-5663213", "R-GGA-8851805", "R-MMU-1250347", "R-SSC-5674135", "R-HSA-4086398", "R-CFA-6807878", "R-CFA-9748787", "R-CEL-193648", "R-SCE-5625740", "R-RNO-8849471", "R-HSA-5655291", "R-GGA-210993", "R-DDI-5687128", "R-DME-6811436", "R-CFA-5625970", "R-DDI-392517", "R-RNO-392451", "R-MMU-5625970", "R-CEL-9615933", "R-CEL-3928665", "R-XTR-354192", "R-DDI-3928662", "R-HSA-9634285", "R-RNO-180336", "R-DRE-4086400", "R-CEL-166208", "R-SPO-8876198", "R-HSA-5654688", "R-SPO-6807878", "R-MMU-389359", "R-MMU-9607240", "R-SCE-5620912", "R-SSC-2179392", "R-RNO-5654704", "R-CEL-354194", "R-CEL-5627083", "R-MMU-9639288", "R-CEL-416482", "R-BTA-9035034", "R-HSA-4420097", "R-CEL-6811440", "R-RNO-392517", "R-CFA-2173791", "R-DME-1660499", "R-HSA-9753512", "R-MMU-5668599", "R-DRE-416572"], "pathways": ["R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-GGA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-BTA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SPO-9013424:r:RHOV GTPase cycle", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-GGA-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-1169092:r:Activation of RAS in B cells", "R-DME-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-CFA-204005:r:COPII-mediated vesicle transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CFA-6785631:r:ERBB2 Regulates Cell Motility", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-GGA-180336:r:SHC1 events in EGFR signaling", "R-GGA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9013106:r:RHOC GTPase cycle", "R-BTA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SSC-5658442:r:Regulation of RAS by GAPs", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-DRE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DME-9013407:r:RHOH GTPase cycle", "R-DME-8854214:r:TBC/RABGAPs", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-CEL-392517:r:Rap1 signalling", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-SCE-8854214:r:TBC/RABGAPs", "R-BTA-5625900:r:RHO GTPases activate CIT", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-CFA-114604:r:GPVI-mediated activation cascade", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-9607240:r:FLT3 Signaling", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-SSC-8851805:r:MET activates RAS signaling", "R-SSC-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-9013026:r:RHOB GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SCE-9696273:r:RND1 GTPase cycle", "R-MMU-9013419:r:RHOT2 GTPase cycle", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-5627117:r:RHO GTPases Activate ROCKs", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DDI-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-SCE-193648:r:NRAGE signals death through JNK", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-GGA-9607240:r:FLT3 Signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-BTA-4086400:r:PCP/CE pathway", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-CFA-9013424:r:RHOV GTPase cycle", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-CFA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-5627083:r:RHO GTPases regulate CFTR trafficking", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-SSC-1169092:r:Activation of RAS in B cells", "R-HSA-114608:r:Platelet degranulation", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-418885:r:DCC mediated attractive signaling", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-CFA-9696264:r:RND3 GTPase cycle", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-RNO-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-2132295:r:MHC class II antigen presentation", "R-GGA-9648002:r:RAS processing", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-418885:r:DCC mediated attractive signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-9648002:r:RAS processing", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-186763:r:Downstream signal transduction", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-5625970:r:RHO GTPases activate KTN1", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-DME-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-165159:r:MTOR signalling", "R-CEL-4086400:r:PCP/CE pathway", "R-GGA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-SSC-186763:r:Downstream signal transduction", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-525793:r:Myogenesis", "R-XTR-6798695:r:Neutrophil degranulation", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-354192:r:Integrin signaling", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-CFA-8875555:r:MET activates RAP1 and RAC1", "R-SCE-9035034:r:RHOF GTPase cycle", "R-SPO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-1632852:r:Macroautophagy", "R-BTA-5620924:r:Intraflagellar transport", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-BTA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-DDI-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-4086398:r:Ca2+ pathway", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-RNO-171007:r:p38MAPK events", "R-CEL-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-BTA-5625970:r:RHO GTPases activate KTN1", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-1169092:r:Activation of RAS in B cells", "R-HSA-9753510:r:Signaling by RAS GAP mutants", "R-SSC-1963640:r:GRB2 events in ERBB2 signaling", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-SSC-182971:r:EGFR downregulation", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-3928664:r:Ephrin signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-SSC-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-264876:r:Insulin processing", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-DRE-8873719:r:RAB geranylgeranylation", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-CFA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-RNO-525793:r:Myogenesis", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-9013148:r:CDC42 GTPase cycle", "R-RNO-1632852:r:Macroautophagy", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-BTA-5626467:r:RHO GTPases activate IQGAPs", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-9013149:r:RAC1 GTPase cycle", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-5620924:r:Intraflagellar transport", "R-SSC-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CFA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-9648002:r:RAS processing", "R-HSA-209563:r:Axonal growth stimulation", "R-DME-389359:r:CD28 dependent Vav1 pathway", "R-GGA-9013419:r:RHOT2 GTPase cycle", "R-GGA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DME-110523:r:TOR signaling pathway", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-HSA-9031628:r:NGF-stimulated transcription", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-GGA-389359:r:CD28 dependent Vav1 pathway", "R-DRE-180336:r:SHC1 events in EGFR signaling", "R-GGA-6811438:r:Intra-Golgi traffic", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-SSC-8854214:r:TBC/RABGAPs", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-SSC-5627123:r:RHO GTPases activate PAKs", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-GGA-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-8873719:r:RAB geranylgeranylation", "R-CFA-182971:r:EGFR downregulation", "R-SSC-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-HSA-9636569:r:Suppression of autophagy", "R-DME-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-CFA-5627123:r:RHO GTPases activate PAKs", "R-CFA-3928664:r:Ephrin signaling", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-CFA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-525793:r:Myogenesis", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-9013420:r:RHOU GTPase cycle", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-8854214:r:TBC/RABGAPs", "R-DME-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-SSC-9013420:r:RHOU GTPase cycle", "R-DME-6811438:r:Intra-Golgi traffic", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-9035034:r:RHOF GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DRE-209563:r:Axonal growth stimulation", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-9013106:r:RHOC GTPase cycle", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-8980692:r:RHOA GTPase cycle", "R-SSC-9013424:r:RHOV GTPase cycle", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-CEL-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-9696273:r:RND1 GTPase cycle", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-354192:r:Integrin signaling", "R-BTA-170968:r:Frs2-mediated activation", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-5627083:r:RHO GTPases regulate CFTR trafficking", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-CFA-5663220:r:RHO GTPases Activate Formins", "R-GGA-1169092:r:Activation of RAS in B cells", "R-SPO-165159:r:MTOR signalling", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-DRE-9013425:r:RHOT1 GTPase cycle", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-SSC-171007:r:p38MAPK events", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CFA-9706019:r:RHOBTB3 ATPase cycle", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-HSA-8873719:r:RAB geranylgeranylation", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-GGA-2424491:r:DAP12 signaling", "R-CFA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-525793:r:Myogenesis", "R-CFA-389359:r:CD28 dependent Vav1 pathway", "R-RNO-9648002:r:RAS processing", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-171007:r:p38MAPK events", "R-GGA-171007:r:p38MAPK events", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DDI-171007:r:p38MAPK events", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-DME-5627117:r:RHO GTPases Activate ROCKs", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DRE-392517:r:Rap1 signalling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-GGA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-9013026:r:RHOB GTPase cycle", "R-XTR-9013419:r:RHOT2 GTPase cycle", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-DDI-8854214:r:TBC/RABGAPs", "R-MMU-6811438:r:Intra-Golgi traffic", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CFA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-CFA-8854214:r:TBC/RABGAPs", "R-GGA-354192:r:Integrin signaling", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-9696270:r:RND2 GTPase cycle", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-GGA-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-CFA-2132295:r:MHC class II antigen presentation", "R-DRE-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-186763:r:Downstream signal transduction", "R-CEL-389359:r:CD28 dependent Vav1 pathway", "R-CFA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-BTA-9013425:r:RHOT1 GTPase cycle", "R-GGA-375165:r:NCAM signaling for neurite out-growth", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-8851805:r:MET activates RAS signaling", "R-BTA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-170984:r:ARMS-mediated activation", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-354192:r:Integrin signaling", "R-GGA-5673000:r:RAF activation", "R-GGA-9013424:r:RHOV GTPase cycle", "R-SCE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-BTA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2132295:r:MHC class II antigen presentation", "R-GGA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DRE-5625970:r:RHO GTPases activate KTN1", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CFA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DRE-179812:r:GRB2 events in EGFR signaling", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-CFA-9696273:r:RND1 GTPase cycle", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-180746:r:Nuclear import of Rev protein", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-DME-5689880:r:Ub-specific processing proteases", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-9013408:r:RHOG GTPase cycle", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-DME-210993:r:Tie2 Signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-170968:r:Frs2-mediated activation", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-RNO-9748787:r:Azathioprine ADME", "R-DME-5673000:r:RAF activation", "R-CEL-525793:r:Myogenesis", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-CFA-209563:r:Axonal growth stimulation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-445144:r:Signal transduction by L1", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-354192:r:Integrin signaling", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-DRE-8851805:r:MET activates RAS signaling", "R-MMU-114608:r:Platelet degranulation", "R-SSC-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CFA-8873719:r:RAB geranylgeranylation", "R-DDI-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-186763:r:Downstream signal transduction", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1169092:r:Activation of RAS in B cells", "R-DME-166208:r:mTORC1-mediated signalling", "R-DRE-5675221:r:Negative regulation of MAPK pathway", "R-DME-9013406:r:RHOQ GTPase cycle", "R-CFA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-170968:r:Frs2-mediated activation", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-SSC-210500:r:Glutamate Neurotransmitter Release Cycle", "R-GGA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DDI-1169092:r:Activation of RAS in B cells", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-MMU-8854214:r:TBC/RABGAPs", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-GGA-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-GGA-5658442:r:Regulation of RAS by GAPs", "R-GGA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SSC-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-5673000:r:RAF activation", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-CFA-8980692:r:RHOA GTPase cycle", "R-BTA-182971:r:EGFR downregulation", "R-HSA-2424491:r:DAP12 signaling", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-8951936:r:RUNX3 regulates p14-ARF", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-DME-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DME-1632852:r:Macroautophagy", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-GGA-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-392517:r:Rap1 signalling", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-354192:r:Integrin signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-SPO-9013420:r:RHOU GTPase cycle", "R-SPO-198203:r:PI3K/AKT activation", "R-MMU-3928664:r:Ephrin signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DDI-1632852:r:Macroautophagy", "R-GGA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-SSC-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-SCE-9696264:r:RND3 GTPase cycle", "R-DDI-166208:r:mTORC1-mediated signalling", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-GGA-5654712:r:FRS-mediated FGFR4 signaling", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-SCE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CEL-198203:r:PI3K/AKT activation", "R-HSA-8875656:r:MET receptor recycling", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-DDI-354192:r:Integrin signaling", "R-CFA-4086400:r:PCP/CE pathway", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-BTA-9013424:r:RHOV GTPase cycle", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-DME-4086400:r:PCP/CE pathway", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-SPO-9013106:r:RHOC GTPase cycle", "R-DME-2424491:r:DAP12 signaling", "R-SSC-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-SCE-9013420:r:RHOU GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-CFA-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-XTR-392517:r:Rap1 signalling", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-9748787:r:Azathioprine ADME", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-SCE-198203:r:PI3K/AKT activation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-DME-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-SCE-392517:r:Rap1 signalling", "R-DME-5625900:r:RHO GTPases activate CIT", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-CFA-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-1632852:r:Macroautophagy", "R-SCE-8873719:r:RAB geranylgeranylation", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-CEL-418885:r:DCC mediated attractive signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-SPO-9013409:r:RHOJ GTPase cycle", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-CFA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-354192:r:Integrin signaling", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CFA-9013420:r:RHOU GTPase cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-8873719:r:RAB geranylgeranylation", "R-DME-198203:r:PI3K/AKT activation", "R-MMU-166208:r:mTORC1-mediated signalling", "R-MMU-2424491:r:DAP12 signaling", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-CFA-193648:r:NRAGE signals death through JNK", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-CFA-9013409:r:RHOJ GTPase cycle", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-5625970:r:RHO GTPases activate KTN1", "R-DDI-8873719:r:RAB geranylgeranylation", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-MMU-1632852:r:Macroautophagy", "R-DRE-1250347:r:SHC1 events in ERBB4 signaling", "R-CFA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-DDI-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CEL-182971:r:EGFR downregulation", "R-CEL-1169092:r:Activation of RAS in B cells", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-165159:r:MTOR signalling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-DME-9607240:r:FLT3 Signaling", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DRE-1169092:r:Activation of RAS in B cells", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-DRE-186763:r:Downstream signal transduction", "R-HSA-373752:r:Netrin-1 signaling", "R-DDI-6811438:r:Intra-Golgi traffic", "R-BTA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-171007:r:p38MAPK events", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-8854214:r:TBC/RABGAPs", "R-BTA-6785631:r:ERBB2 Regulates Cell Motility", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-165159:r:MTOR signalling", "R-DRE-198203:r:PI3K/AKT activation", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-9013420:r:RHOU GTPase cycle", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SSC-6798695:r:Neutrophil degranulation", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SSC-5626467:r:RHO GTPases activate IQGAPs", "R-CFA-5625740:r:RHO GTPases activate PKNs", "R-RNO-166208:r:mTORC1-mediated signalling", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-GGA-9013408:r:RHOG GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-CFA-9696270:r:RND2 GTPase cycle", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-SSC-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-392517:r:Rap1 signalling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-GGA-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-3928664:r:Ephrin signaling", "R-CFA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SSC-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DDI-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-BTA-6811438:r:Intra-Golgi traffic", "R-BTA-209563:r:Axonal growth stimulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-CEL-5626467:r:RHO GTPases activate IQGAPs", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-CEL-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-CEL-8854214:r:TBC/RABGAPs", "R-GGA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-5674135:r:MAP2K and MAPK activation", "R-HSA-3928664:r:Ephrin signaling", "R-CFA-9032759:r:NTRK2 activates RAC1", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SSC-5654719:r:SHC-mediated cascade:FGFR4", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CFA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-DRE-8875656:r:MET receptor recycling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-9013425:r:RHOT1 GTPase cycle", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-MMU-9648002:r:RAS processing", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-DME-525793:r:Myogenesis", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-DRE-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-CFA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-9013409:r:RHOJ GTPase cycle", "R-SPO-8873719:r:RAB geranylgeranylation", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-CEL-6811438:r:Intra-Golgi traffic", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-SSC-2871796:r:FCERI mediated MAPK activation", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-SSC-179812:r:GRB2 events in EGFR signaling", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-CEL-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SSC-5654704:r:SHC-mediated cascade:FGFR3", "R-SSC-2424491:r:DAP12 signaling", "R-SPO-9035034:r:RHOF GTPase cycle", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CFA-5625900:r:RHO GTPases activate CIT", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-SCE-165159:r:MTOR signalling", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-165159:r:MTOR signalling", "R-BTA-8854214:r:TBC/RABGAPs", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-5673000:r:RAF activation", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-RNO-9607240:r:FLT3 Signaling", "R-CEL-5673000:r:RAF activation", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-525793:r:Myogenesis", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-165159:r:MTOR signalling", "R-DME-3928664:r:Ephrin signaling", "R-SPO-389359:r:CD28 dependent Vav1 pathway", "R-GGA-9013420:r:RHOU GTPase cycle", "R-GGA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-CFA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-4086400:r:PCP/CE pathway", "R-SSC-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-209563:r:Axonal growth stimulation", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-8851805:r:MET activates RAS signaling", "R-CFA-8875656:r:MET receptor recycling", "R-CFA-198203:r:PI3K/AKT activation", "R-DRE-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-9648002:r:RAS processing", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CFA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-CFA-2871796:r:FCERI mediated MAPK activation", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DDI-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-SSC-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-SCE-9013409:r:RHOJ GTPase cycle", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-CFA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-9013106:r:RHOC GTPase cycle", "R-MMU-8873719:r:RAB geranylgeranylation", "R-CFA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-CEL-8873719:r:RAB geranylgeranylation", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CFA-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-182971:r:EGFR downregulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-CFA-2424491:r:DAP12 signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-GGA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-CFA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DME-114604:r:GPVI-mediated activation cascade", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-9013424:r:RHOV GTPase cycle", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-SPO-9696273:r:RND1 GTPase cycle", "R-CFA-9013408:r:RHOG GTPase cycle", "R-DRE-1963640:r:GRB2 events in ERBB2 signaling", "R-SSC-180336:r:SHC1 events in EGFR signaling", "R-HSA-164944:r:Nef and signal transduction", "R-BTA-392517:r:Rap1 signalling", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-SPO-9696264:r:RND3 GTPase cycle", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-XTR-8875555:r:MET activates RAP1 and RAC1", "R-SSC-525793:r:Myogenesis", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-CEL-5627123:r:RHO GTPases activate PAKs", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SSC-9696264:r:RND3 GTPase cycle", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-418885:r:DCC mediated attractive signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-BTA-114608:r:Platelet degranulation", "R-CFA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-5625740:r:RHO GTPases activate PKNs", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-SSC-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-350407:r:RHO1 GTPase cycle", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-GGA-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-4086400:r:PCP/CE pathway", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-209563:r:Axonal growth stimulation", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-GGA-182971:r:EGFR downregulation", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-BTA-198203:r:PI3K/AKT activation", "R-SSC-9607240:r:FLT3 Signaling", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-GGA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-9607240:r:FLT3 Signaling", "R-CEL-4086398:r:Ca2+ pathway", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-4086400:r:PCP/CE pathway", "R-SPO-8854214:r:TBC/RABGAPs", "R-MMU-392517:r:Rap1 signalling", "R-MMU-5625900:r:RHO GTPases activate 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"R-SSC-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-DDI-5673000:r:RAF activation", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-8875656:r:MET receptor recycling", "R-DDI-445144:r:Signal transduction by L1", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SPO-5626467:r:RHO GTPases activate IQGAPs", "R-SPO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SSC-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-210993:r:Tie2 Signaling", "R-RNO-445144:r:Signal transduction by L1", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CFA-445144:r:Signal transduction by L1", "R-SSC-114604:r:GPVI-mediated activation cascade", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-CEL-9648002:r:RAS processing", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-BTA-170984:r:ARMS-mediated activation", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DME-182971:r:EGFR downregulation", "R-CEL-170968:r:Frs2-mediated activation", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DRE-9013419:r:RHOT2 GTPase cycle", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-SSC-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-8854214:r:TBC/RABGAPs", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-DDI-165159:r:MTOR signalling", "R-GGA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-SCE-6798695:r:Neutrophil degranulation", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-CFA-9035034:r:RHOF GTPase cycle", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-CFA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-8851805:r:MET activates RAS signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-HSA-4086398:r:Ca2+ pathway", "R-CFA-6807878:r:COPI-mediated anterograde transport", "R-CFA-9748787:r:Azathioprine ADME", "R-CEL-193648:r:NRAGE signals death through JNK", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-GGA-210993:r:Tie2 Signaling", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-CFA-5625970:r:RHO GTPases activate KTN1", "R-DDI-392517:r:Rap1 signalling", "R-RNO-392451:r:G beta:gamma 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"R-HSA-2644607", "R-RNO-8951664", "R-BTA-917937", "R-DRE-176417", "R-HSA-180534", "R-SPO-8951664", "R-HSA-2644606", "R-RNO-983168", "R-CFA-983168", "R-MMU-69231", "R-BTA-8951664", "R-HSA-68949", "R-HSA-187577", "R-HSA-5610785", "R-MMU-187577", "R-HSA-3769402", "R-HSA-69205", "R-MMU-68949", "R-SSC-8951664", "R-MMU-174178", "R-CEL-983168", "R-DDI-9013149", "R-MMU-69601", "R-DRE-983168", "R-HSA-2565942", "R-CEL-8854050", "R-MMU-917937", "R-DDI-381676", "R-HSA-2871837", "R-MMU-3214842", "R-HSA-167152", "R-DRE-917937", "R-MMU-8854050", "R-SPO-983168", "R-SCE-983168", "R-DRE-176408", "R-HSA-9762114", "R-HSA-5607764", "R-MMU-202424", "R-HSA-195253", "R-MMU-176408", "R-HSA-5610780", "R-DDI-171007", "R-MMU-6796648", "R-HSA-390471", "R-HSA-167243", "R-RNO-6796648", "R-RNO-75955", "R-MMU-176417", "R-DDI-392517", "R-HSA-3214842", "R-HSA-2894862", "R-MMU-1169091", "R-HSA-69601", "R-HSA-983168", "R-XTR-8951664", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-8939902", "R-DDI-983168", "R-HSA-9929356", "R-HSA-167290", "R-XTR-983168", "R-HSA-75955", "R-MMU-8939902", "R-HSA-917937", "R-DRE-8854050", "R-MMU-983168", "R-HSA-176417", "R-HSA-674695", "R-HSA-202424", "R-DDI-1169092", "R-HSA-112382", "R-CEL-8951664", "R-DRE-68881"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-354192:r:Integrin signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-CFA-8951664:r:Neddylation", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-9907900:r:Proteasome assembly", "R-DRE-8951664:r:Neddylation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-8951664:r:Neddylation", "R-HSA-68881:r:Mitotic Metaphase/Anaphase Transition", "R-MMU-8951664:r:Neddylation", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-68881:r:Mitotic Metaphase/Anaphase Transition", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-193648:r:NRAGE signals death through JNK", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-RNO-8951664:r:Neddylation", "R-BTA-917937:r:Iron uptake and transport", "R-DRE-176417:r:Phosphorylation of Emi1", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-BTA-8951664:r:Neddylation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-68949:r:Orc1 removal from chromatin", "R-SSC-8951664:r:Neddylation", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-917937:r:Iron uptake and transport", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DRE-917937:r:Iron uptake and transport", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-171007:r:p38MAPK events", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-176417:r:Phosphorylation of Emi1", "R-DDI-392517:r:Rap1 signalling", "R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-8951664:r:Neddylation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-917937:r:Iron uptake and transport", "R-DRE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-176417:r:Phosphorylation of Emi1", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-1169092:r:Activation of RAS in B cells", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-8951664:r:Neddylation", "R-DRE-68881:r:Mitotic Metaphase/Anaphase Transition"], "type": "Domain"}, "IPR001811": {"description": "Chemokine interleukin-8-like domain", "go_ids": ["GO:0005576", "GO:0006955", "GO:0008009"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006955:immune response:P", "GO:0008009:chemokine activity:F"], "name": "Chemokine_IL8-like_dom", "pathway_ids": ["R-HSA-6798695", "R-MMU-416476", "R-SSC-6798695", "R-MMU-444473", "R-HSA-9942503", "R-SSC-380108", "R-GGA-418594", "R-HSA-375276", "R-HSA-8936459", "R-HSA-1251985", "R-SSC-114608", "R-MMU-380108", "R-RNO-444473", "R-RNO-140875", "R-BTA-6798695", "R-HSA-2559582", "R-HSA-416476", "R-CFA-380108", "R-GGA-375276", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-BTA-418594", "R-HSA-380994", "R-RNO-202733", "R-MMU-202733", "R-HSA-444473", "R-RNO-416476", "R-HSA-6783783", "R-HSA-9018519", "R-HSA-9610379", "R-HSA-376176", "R-GGA-114608", "R-HSA-6785807", "R-HSA-140875", "R-MMU-140875", "R-CFA-375276", "R-SSC-375276", "R-HSA-418594", "R-MMU-376176", "R-HSA-380108", "R-HSA-9818026", "R-BTA-380108", "R-CFA-418594", "R-GGA-380108", "R-SSC-418594", "R-MMU-6798695", "R-RNO-380108", "R-HSA-202733", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-SSC-380108:r:Chemokine receptors bind chemokines", "R-GGA-418594:r:G alpha (i) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-114608:r:Platelet degranulation", "R-MMU-380108:r:Chemokine receptors bind chemokines", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-416476:r:G alpha (q) signalling events", "R-CFA-380108:r:Chemokine receptors bind chemokines", "R-GGA-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-376176:r:Signaling by ROBO receptors", "R-GGA-114608:r:Platelet degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-CFA-375276:r:Peptide ligand-binding receptors", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-380108:r:Chemokine receptors bind chemokines", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-BTA-380108:r:Chemokine receptors bind chemokines", "R-CFA-418594:r:G alpha (i) signalling events", "R-GGA-380108:r:Chemokine receptors bind chemokines", "R-SSC-418594:r:G alpha (i) signalling events", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-380108:r:Chemokine receptors bind chemokines", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR001812": {"description": "Variant surface glycoprotein, N-terminal domain", "go_ids": ["GO:0042783"], "go_terms": ["GO:0042783:symbiont-mediated evasion of host immune response:P"], "name": "VSG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001816": {"description": "Translation elongation factor EFTs/EF1B", "go_ids": ["GO:0003746", "GO:0006414"], "go_terms": ["GO:0003746:translation elongation factor activity:F", "GO:0006414:translational elongation:P"], "name": "Transl_elong_EFTs/EF1B", "pathway_ids": ["R-HSA-5389840"], "pathways": ["R-HSA-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR001818": {"description": "Peptidase M10, metallopeptidase", "go_ids": ["GO:0004222", "GO:0006508", "GO:0031012", "GO:0008270"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0031012:extracellular matrix:C", "GO:0008270:zinc ion binding:F"], "name": "Pept_M10_metallopeptidase", "pathway_ids": ["R-CEL-1592389", "R-HSA-6798695", "R-RNO-2022090", "R-MMU-210991", "R-MMU-3928665", "R-RNO-1474228", "R-CEL-6798695", "R-RNO-9009391", "R-BTA-6798695", "R-HSA-2179392", "R-MMU-9009391", "R-CFA-1442490", "R-SSC-1474228", "R-RNO-2179392", "R-GGA-9009391", "R-RNO-3928665", "R-DME-3928665", "R-HSA-210991", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-MMU-1433557", "R-SSC-1592389", "R-MMU-1592389", "R-BTA-1474228", "R-RNO-9839383", "R-DME-1592389", "R-HSA-6785807", "R-GGA-1442490", "R-HSA-8941332", "R-RNO-381426", "R-RNO-1433557", "R-BTA-1592389", "R-HSA-2022090", "R-CFA-1474228", "R-MMU-6798695", "R-RNO-6798695", "R-MMU-9839383", "R-MMU-2179392", "R-GGA-1474228", "R-BTA-1442490", "R-CEL-2179392", "R-CFA-2022090", "R-CEL-1474228", "R-SSC-1442490", "R-HSA-9918481", "R-GGA-1592389", "R-HSA-1442490", "R-BTA-1433557", "R-CFA-2179392", "R-CFA-1592389", "R-CEL-210991", "R-RNO-1592389", "R-DME-6798695", "R-DME-2179392", "R-CFA-9009391", "R-HSA-9839383", "R-HSA-1592389", "R-DME-2022090", "R-HSA-1433557", "R-RNO-1442490", "R-BTA-9009391", "R-CEL-3928665", "R-MMU-2022090", "R-DME-1474228", "R-HSA-9009391", "R-HSA-3928665", "R-GGA-3928665", "R-DME-1442490", "R-CEL-1442490", "R-HSA-9856530", "R-BTA-3928665", "R-MMU-1442490"], "pathways": ["R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-210991:r:Basigin interactions", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-1442490:r:Collagen degradation", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-210991:r:Basigin interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-SSC-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-1442490:r:Collagen degradation", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", 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"R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-CEL-210991:r:Basigin interactions", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-1442490:r:Collagen degradation", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", 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"R-DDI-975163", "R-HSA-6802946", "R-HSA-167152", "R-HSA-1236382", "R-DRE-975163", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-9833110", "R-HSA-5656169", "R-HSA-937072", "R-HSA-5607764", "R-HSA-2173796", "R-XTR-9758274", "R-MMU-1358803", "R-SCE-6796648", "R-RNO-8948747", "R-XTR-2871837", "R-MMU-3769402", "R-MMU-5357786", "R-SPO-77075", "R-MMU-8849469", "R-SCE-113418", "R-BTA-174048", "R-XTR-9013424", "R-RNO-111469", "R-RNO-975871", "R-MMU-8939243", "R-MMU-176407", "R-HSA-5213460", "R-HSA-5668541", "R-CEL-68949", "R-DME-5632684", "R-HSA-5687128", "R-SPO-5696400", "R-DME-8936459", "R-BTA-450302", "R-HSA-9705462", "R-DRE-9954716", "R-RNO-5357956", "R-MMU-9758274", "R-DDI-174178", "R-HSA-110320", "R-BTA-975163"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-SSC-193692:r:Regulated proteolysis of p75NTR", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-2559585:r:Oncogene Induced Senescence", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-72086:r:mRNA Capping", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-9031628:r:NGF-stimulated transcription", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-3899300:r:SUMOylation of transcription cofactors", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-MMU-429947:r:Deadenylation of mRNA", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-912446:r:Meiotic recombination", "R-CFA-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-XTR-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-9013424:r:RHOV GTPase cycle", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SSC-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-RNO-9020702:r:Interleukin-1 signaling", "R-XTR-209560:r:NF-kB is activated and signals survival", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SSC-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-XTR-8948751:r:Regulation of PTEN stability and activity", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-8948747:r:Regulation of PTEN localization", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-XTR-5689880:r:Ub-specific processing proteases", "R-HSA-1266695:r:Interleukin-7 signaling", "R-DRE-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-BTA-193692:r:Regulated proteolysis of p75NTR", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-3371378:r:Regulation by c-FLIP", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DRE-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CFA-5689880:r:Ub-specific processing proteases", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-212436:r:Generic Transcription Pathway", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-XTR-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-DME-216167:r:Nuclear CI is degraded", "R-HSA-5334118:r:DNA methylation", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-SCE-72086:r:mRNA Capping", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-9020702:r:Interleukin-1 signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CFA-8953750:r:Transcriptional Regulation by E2F6", "R-GGA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-SSC-209543:r:p75NTR recruits signalling complexes", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-XTR-209543:r:p75NTR recruits signalling complexes", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-DRE-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-9033241:r:Peroxisomal protein import", "R-DME-390150:r:DS ligand bound to FT receptor", "R-BTA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-SCE-9033241:r:Peroxisomal protein import", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-9646399:r:Aggrephagy", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SSC-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-DDI-9033241:r:Peroxisomal protein import", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-6782135:r:Dual incision in TC-NER", "R-GGA-4570464:r:SUMOylation of RNA binding proteins", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-4551638:r:SUMOylation of chromatin organization proteins", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-69416:r:Dimerization of procaspase-8", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-167161:r:HIV Transcription Initiation", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-XTR-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-9833482:r:PKR-mediated signaling", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-GGA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-69541:r:Stabilization of p53", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-167172:r:Transcription of the HIV genome", "R-SSC-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-SCE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-XTR-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-912631:r:Regulation of signaling by CBL", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-9706369:r:Negative regulation of FLT3", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689880:r:Ub-specific processing proteases", "R-DRE-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SSC-9758274:r:Regulation of NF-kappa B signaling", "R-DME-5696400:r:Dual Incision in GG-NER", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-XTR-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-182971:r:EGFR downregulation", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-69541:r:Stabilization of p53", "R-DME-8951664:r:Neddylation", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-75893:r:TNF signaling", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-CFA-69541:r:Stabilization of p53", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9663199:r:Defective DNA double strand break response due to BRCA1 loss of function", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-75893:r:TNF signaling", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-XTR-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-5689603:r:UCH proteinases", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-SSC-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-4641258:r:Degradation of DVL", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-GGA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DME-111469:r:SMAC, XIAP-regulated apoptotic response", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-SSC-5689880:r:Ub-specific processing proteases", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-DME-68949:r:Orc1 removal from chromatin", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-CFA-9766229:r:Degradation of CDH1", "R-DRE-5689880:r:Ub-specific processing proteases", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-171007:r:p38MAPK events", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8948747:r:Regulation of PTEN localization", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-912631:r:Regulation of signaling by CBL", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CFA-2559585:r:Oncogene Induced Senescence", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DRE-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-1170546:r:Prolactin receptor signaling", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-MMU-5673000:r:RAF activation", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-MMU-69416:r:Dimerization of procaspase-8", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-DDI-4641258:r:Degradation of DVL", "R-CEL-6782135:r:Dual incision in TC-NER", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-RNO-111463:r:SMAC (DIABLO) binds to IAPs", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9706369:r:Negative regulation of FLT3", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-3214847:r:HATs acetylate histones", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-5689880:r:Ub-specific processing proteases", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-1433559:r:Regulation of KIT signaling", "R-GGA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-DRE-4641263:r:Regulation of FZD by ubiquitination", "R-XTR-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-5689901:r:Metalloprotease DUBs", "R-BTA-202424:r:Downstream TCR signaling", "R-CFA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-SSC-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DRE-9020702:r:Interleukin-1 signaling", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-HSA-212436:r:Generic Transcription Pathway", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-SSC-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-GGA-3214847:r:HATs acetylate histones", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-4641258:r:Degradation of DVL", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-9770562:r:mRNA Polyadenylation", "R-SPO-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-GGA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-4641257:r:Degradation of AXIN", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-CFA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5689603:r:UCH proteinases", "R-CFA-8943724:r:Regulation of PTEN gene transcription", "R-DRE-209560:r:NF-kB is activated and signals survival", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1170546:r:Prolactin receptor signaling", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-69541:r:Stabilization of p53", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-DDI-1169092:r:Activation of RAS in B cells", "R-SSC-937039:r:IRAK1 recruits IKK complex", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CEL-5632684:r:Hedgehog 'on' state", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-XTR-202424:r:Downstream TCR signaling", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-5689901:r:Metalloprotease DUBs", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-CFA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-5673000:r:RAF activation", "R-CFA-937041:r:IKK complex recruitment mediated by RIP1", "R-GGA-8943724:r:Regulation of PTEN gene transcription", "R-XTR-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-3371378:r:Regulation by c-FLIP", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-DRE-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DRE-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-182971:r:EGFR downregulation", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-429947:r:Deadenylation of mRNA", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-DRE-937039:r:IRAK1 recruits IKK complex", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-9699150:r:Defective DNA double strand break response due to BARD1 loss of function", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-5689896:r:Ovarian tumor domain proteases", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-4641257:r:Degradation of AXIN", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SSC-9020702:r:Interleukin-1 signaling", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-MMU-202424:r:Downstream TCR signaling", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-SPO-69231:r:Cyclin D associated events in G1", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DDI-392517:r:Rap1 signalling", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-XTR-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-202424:r:Downstream TCR signaling", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DME-3214847:r:HATs acetylate histones", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-CEL-5673000:r:RAF activation", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-354192:r:Integrin signaling", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-BTA-9013424:r:RHOV GTPase cycle", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-MMU-69541:r:Stabilization of p53", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-9020702:r:Interleukin-1 signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-3322077:r:Glycogen synthesis", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CFA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SSC-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-DDI-68949:r:Orc1 removal from chromatin", "R-RNO-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-GGA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-72086:r:mRNA Capping", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DRE-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-8948747:r:Regulation of PTEN localization", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-XTR-9013424:r:RHOV GTPase cycle", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-68949:r:Orc1 removal from chromatin", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Domain"}, "IPR001842": {"description": "Peptidase M36, fungalysin", "go_ids": ["GO:0004222", "GO:0008270", "GO:0005576"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0008270:zinc ion binding:F", "GO:0005576:extracellular region:C"], "name": "Peptidase_M36", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR001843": {"description": "Fragilysin", "go_ids": ["GO:0008237"], "go_terms": ["GO:0008237:metallopeptidase activity:F"], "name": "Fragilysin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001844": {"description": "Chaperonin Cpn60/GroEL", "go_ids": ["GO:0042026", "GO:0140662"], "go_terms": ["GO:0042026:protein refolding:P", "GO:0140662:ATP-dependent protein folding chaperone:F"], "name": "Cpn60/GroEL", "pathway_ids": ["R-DDI-9837999", "R-HSA-8869496", "R-MMU-9837999", "R-CEL-9837999", "R-HSA-1268020", "R-SPO-9837999", "R-GGA-1268020", "R-MMU-1268020", "R-DME-9837999", "R-SCE-9837999", "R-HSA-9841251", "R-GGA-9837999", "R-HSA-9837999", "R-SCE-1268020", "R-RNO-9837999", "R-SPO-1268020", "R-RNO-1268020"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-1268020:r:Mitochondrial protein import", 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subunits", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001849": {"description": "Pleckstrin homology domain", "go_ids": [], "go_terms": [], "name": "PH_domain", "pathway_ids": ["R-HSA-6802955", "R-DDI-6798695", "R-CFA-9013148", "R-HSA-6802948", "R-CEL-74751", "R-RNO-6804759", 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"R-HSA-114508", "R-HSA-9035034", "R-DDI-418592", "R-DME-9013409", "R-CEL-6811438", "R-SCE-9013424", "R-HSA-8851805", "R-MMU-5218921", "R-BTA-1306955", "R-RNO-69202", "R-DME-8876198", "R-CEL-9614399", "R-DME-450385", "R-RNO-982772", "R-SPO-9035034", "R-MMU-2029482", "R-RNO-2428928", "R-BTA-8856825", "R-RNO-2424491", "R-HSA-165159", "R-BTA-8854214", "R-HSA-5663213", "R-RNO-8948751", "R-MMU-1266695", "R-BTA-9696273", "R-MMU-114604", "R-HSA-167021", "R-RNO-9607240", "R-DDI-2179392", "R-CFA-114608", "R-HSA-6811434", "R-MMU-211163", "R-RNO-6811558", "R-MMU-8851805", "R-DME-74751", "R-HSA-9603381", "R-CEL-165159", "R-SPO-389359", "R-GGA-9013420", "R-XTR-9013408", "R-DDI-392451", "R-MMU-9013423", "R-HSA-5654699", "R-MMU-69656", "R-MMU-9841251", "R-HSA-1236974", "R-SSC-1433557", "R-CEL-199418", "R-CEL-165158", "R-RNO-6798695", "R-HSA-9656223", "R-BTA-2029482", "R-RNO-9842663", "R-MMU-5654699", "R-SPO-9013406", "R-HSA-5620916", "R-CEL-111933", "R-MMU-165158", "R-HSA-2730905", "R-MMU-6804759", "R-MMU-111465", "R-DME-5654699", "R-MMU-9027284", "R-BTA-1433557", "R-CEL-9013423", "R-BTA-512988", "R-DDI-2029482", "R-DME-389513", "R-HSA-1963640", "R-MMU-912631", "R-DME-112399", "R-DME-112412", "R-DME-432722", "R-RNO-391160", "R-RNO-1660499", "R-BTA-9013404", "R-BTA-1257604", "R-CEL-9009391", "R-RNO-5654219", "R-MMU-9013149", "R-DME-9856530", "R-MMU-182971", "R-MMU-8964315", "R-HSA-5674135", "R-DME-375165", "R-DME-114604", "R-RNO-5635838", "R-CEL-9013424", "R-RNO-74749", "R-HSA-2179392", "R-HSA-9013424", "R-GGA-9013106", "R-MMU-2871796", "R-MMU-9013422", "R-RNO-2029485", "R-HSA-164944", "R-HSA-9664565", "R-DME-445095", "R-MMU-982772", "R-HSA-8854521", "R-BTA-264876", "R-RNO-418885", "R-BTA-166016", "R-HSA-9013404", "R-SCE-9013148", "R-DME-9755511", "R-DME-165158", "R-DME-445144", "R-HSA-9703648", "R-DME-1963640", "R-HSA-372708", "R-DME-5628897", "R-BTA-8865999", "R-RNO-264876", "R-MMU-8856825", "R-DME-5654720", "R-MMU-432722", "R-HSA-977443", "R-RNO-111933", "R-HSA-418885", "R-HSA-1169408", "R-HSA-198323", "R-MMU-372708", "R-BTA-114608", "R-DDI-170670", "R-DME-2871809", "R-XTR-9696264", "R-XTR-9013423", "R-DDI-389513", "R-MMU-432720", "R-DRE-9013408", "R-HSA-9679191", "R-MMU-983695", "R-HSA-1433557", "R-DDI-165158", "R-HSA-9703465", "R-GGA-8964616", "R-DDI-434316", "R-MMU-9026527", "R-CEL-211163", "R-MMU-8856828", "R-DDI-114516", "R-SSC-9607240", "R-BTA-8851907", "R-RNO-446388", "R-HSA-203615", "R-GGA-416482", "R-CEL-9607240", "R-DRE-1660661", "R-DME-446353", "R-RNO-193648", "R-MMU-8849471", "R-MMU-9035034", "R-SPO-2029482", "R-DME-109704", "R-MMU-399955", "R-HSA-432720", "R-MMU-5625900", "R-HSA-437239", "R-HSA-418555", "R-RNO-9013148", "R-CEL-1483248", "R-RNO-203615", "R-DME-5218920", "R-RNO-6804757", "R-MMU-912526", "R-XTR-9013404", "R-DDI-5674135", "R-MMU-5654219", "R-DME-193648", "R-RNO-2730905", "R-HSA-1855204", "R-MMU-1963642", "R-MMU-977443", "R-MMU-9696264", "R-MMU-5654712", "R-BTA-5654689", "R-HSA-9680350", "R-RNO-9634638", "R-MMU-9614399", "R-DME-180336", "R-DDI-9009391", "R-HSA-1251985", "R-RNO-8980692", "R-RNO-1257604", "R-XTR-9013026", "R-DRE-9013404", "R-CEL-2179392", "R-DDI-9013422", "R-MMU-69202", "R-CEL-9748787", "R-CEL-5654712", "R-DDI-418594", "R-CEL-9013406", "R-HSA-112399", "R-RNO-5627117", "R-HSA-9706369", "R-BTA-180292", "R-HSA-5666185", "R-HSA-109704", "R-HSA-9034864", "R-MMU-354194", "R-MMU-1257604", "R-HSA-9842663", "R-DDI-9648002", "R-DME-2730905", "R-HSA-8856825", "R-HSA-428540", "R-BTA-9027276", "R-SCE-389359", "R-HSA-5602498", "R-RNO-166016", "R-CEL-198323", "R-MMU-1963640", "R-DME-9604323", "R-HSA-180292", "R-MMU-9013106", "R-RNO-1483166", "R-HSA-166016", "R-CFA-1660499", "R-RNO-5621480", "R-CEL-432722", "R-HSA-9026519", "R-DRE-5673001", "R-MMU-416572", "R-HSA-9841922", "R-MMU-389357", "R-BTA-389359", "R-MMU-5654695", "R-RNO-1474151", "R-MMU-74751", "R-DME-3928665", "R-RNO-9013408", "R-DDI-9013423", "R-DME-6807878", "R-RNO-5673001", "R-HSA-212718", "R-HSA-373753", "R-DME-5654704", "R-MMU-180292", "R-HSA-210993", "R-RNO-5620916", "R-DME-437239", "R-HSA-9034793", "R-RNO-6811438", "R-DME-3928662", "R-HSA-2029482", "R-DRE-354192", "R-HSA-5218921", "R-SPO-8980692", "R-CEL-6804758", "R-DME-8853659", "R-HSA-5635838", "R-DME-9841251", "R-CEL-1963640", "R-DRE-354194", "R-MMU-8854521", "R-MMU-9027276", "R-DDI-9031628", "R-DME-1474151", "R-RNO-211163", "R-DDI-1489509", "R-DRE-9013423", "R-HSA-165158", "R-HSA-167044", "R-DME-5654700", "R-CEL-69202", "R-CEL-190873", "R-RNO-109704", "R-MMU-9755511", "R-DME-9013424", "R-MMU-983231", "R-HSA-1660499", "R-HSA-375165", "R-MMU-9842663", "R-HSA-6804758", "R-RNO-8849469", "R-DRE-9013149", "R-CEL-5654699", "R-DME-9748787", "R-DME-180292", "R-RNO-1266695", "R-MMU-1170546", "R-HSA-9645135", "R-CEL-198693", "R-DME-5654689", "R-DME-983695", "R-BTA-1660661", "R-CEL-1169408", "R-RNO-5607764", "R-MMU-8875656", "R-RNO-182971", "R-HSA-69202", "R-HSA-392451", "R-MMU-418885", "R-HSA-9013409", "R-RNO-445095", "R-MMU-9674555", "R-GGA-9013026", "R-MMU-198323", "R-RNO-9009391", "R-DDI-416476", "R-RNO-1433559", "R-HSA-442982", "R-HSA-5218920", "R-DDI-5213460", "R-RNO-8854521", "R-RNO-112412", "R-GGA-9013404", "R-DDI-5218920", "R-DDI-5673000", "R-BTA-8875656", "R-HSA-165181", "R-DDI-445144", "R-HSA-203641", "R-HSA-9027283", "R-RNO-212718", "R-RNO-210993", "R-HSA-111447", "R-HSA-416482", "R-SPO-9013148", "R-HSA-9696264", "R-DME-450604", "R-MMU-1483166", "R-DME-5654695", "R-HSA-1445148", "R-MMU-193648", "R-HSA-111933", "R-HSA-9013026", "R-MMU-6804758", "R-MMU-2730905", "R-HSA-9664323", "R-DME-389357", "R-HSA-1839117", "R-CEL-8849932", "R-HSA-5655253", "R-DME-1358803", "R-HSA-6811438", "R-DME-5673001", "R-DME-418555", "R-DDI-165159", "R-HSA-8854214", "R-SCE-6798695", "R-MMU-983189", "R-HSA-9013106", "R-HSA-2428933", "R-CEL-5607764", "R-HSA-9614399", "R-MMU-1250347", "R-MMU-112412", "R-HSA-9027276", "R-CEL-193648", "R-HSA-389513", "R-RNO-8849471", "R-HSA-5655291", "R-MMU-109704", "R-DDI-5687128", "R-MMU-8849474", "R-MMU-6804757", "R-HSA-9841251", "R-DME-9856649", "R-RNO-392451", "R-MMU-8983432", "R-DDI-2514859", "R-CEL-3928665", "R-HSA-450385", "R-MMU-212718", "R-HSA-5654219", "R-DDI-3928662", "R-BTA-109704", "R-HSA-9634285", "R-HSA-201556", "R-HSA-446388", "R-BTA-9027284", "R-MMU-5654689", "R-MMU-74749", "R-HSA-8964315", "R-HSA-5654688", "R-XTR-9013106", "R-MMU-389359", "R-MMU-9607240", "R-RNO-983189", "R-CEL-354194", "R-CEL-912631", "R-CEL-416482", "R-BTA-190873", "R-HSA-4420097", "R-DME-1660499", "R-CEL-1433559", "R-CEL-9856649", "R-SCE-192105", "R-DME-6804759", "R-RNO-201556", "R-HSA-9665686", "R-MMU-192105", "R-HSA-9755511", "R-BTA-912631", "R-RNO-8964616", "R-MMU-111933", "R-MMU-8875555", "R-DME-5654710", "R-RNO-389513", "R-CFA-9013106", "R-MMU-9913351", "R-HSA-5654720", "R-SPO-9013424", "R-BTA-114604", "R-DRE-446353", "R-HSA-418890", "R-HSA-8948751", "R-MMU-199418", "R-MMU-5654688", "R-BTA-9013106", "R-MMU-375165", "R-RNO-977443", "R-DME-392451", "R-SCE-5627123", "R-MMU-203615", "R-MMU-9845576", "R-DDI-9013149", "R-CEL-8876198", "R-HSA-6802946", "R-RNO-190873", "R-BTA-2871796", "R-DME-8856828", "R-RNO-9013106", "R-CEL-1660661", "R-MMU-5654228", "R-MMU-5654719", "R-BTA-5635838", "R-MMU-202433", "R-RNO-6811434", "R-MMU-8849469", "R-CEL-9841251", "R-SSC-1855204", "R-HSA-6807878", "R-MMU-3928663", "R-MMU-9006335", "R-XTR-9035034", "R-CEL-180336", "R-RNO-5625900", "R-BTA-9013408", "R-RNO-5218921", "R-DDI-1483166", "R-DDI-114508", "R-MMU-9634638", "R-DRE-416476", "R-RNO-186763", "R-HSA-9696273", "R-CEL-5654704", "R-RNO-9013026", "R-DDI-114604", "R-RNO-9013422", "R-GGA-446388", "R-MMU-3928665", "R-HSA-2871796", "R-DDI-202424", "R-HSA-5654695", "R-HSA-69656", "R-SCE-8980692", "R-HSA-9662360", "R-BTA-6811558", "R-RNO-375165"], "pathways": ["R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DDI-6798695:r:Neutrophil degranulation", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-RNO-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-202433:r:Generation of second messenger molecules", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-DME-111933:r:Calmodulin induced events", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-114608:r:Platelet degranulation", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DME-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-354192:r:Integrin signaling", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-MMU-5621480:r:Dectin-2 family", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-74749:r:Signal attenuation", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-DME-186763:r:Downstream signal transduction", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-416476:r:G alpha (q) signalling events", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-165158:r:Activation of AKT2", "R-MMU-165159:r:MTOR signalling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-SCE-9035034:r:RHOF GTPase cycle", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-MMU-264876:r:Insulin processing", "R-DDI-5625740:r:RHO GTPases activate PKNs", "R-HSA-9013407:r:RHOH GTPase cycle", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-DDI-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-198693:r:AKT phosphorylates targets in the nucleus", "R-DDI-165181:r:Inhibition of TSC complex formation by PKB", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-SSC-8853659:r:RET signaling", "R-CEL-202433:r:Generation of second messenger molecules", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-3295583:r:TRP channels", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-983189:r:Kinesins", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-HSA-264876:r:Insulin processing", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-DME-9013148:r:CDC42 GTPase cycle", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-196025:r:Formation of annular gap junctions", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-DME-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-114608:r:Platelet degranulation", "R-HSA-1433559:r:Regulation of KIT signaling", "R-BTA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DME-110523:r:TOR signaling pathway", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-HSA-1483166:r:Synthesis of PA", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-GGA-193648:r:NRAGE signals death through JNK", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-BTA-2132295:r:MHC class II antigen presentation", "R-RNO-1170546:r:Prolactin receptor signaling", "R-DDI-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-167044:r:Signalling to RAS", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-203615:r:eNOS activation", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-SSC-74713:r:IRS activation", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-DME-9013420:r:RHOU GTPase cycle", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-8854214:r:TBC/RABGAPs", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-9035034:r:RHOF GTPase cycle", "R-RNO-112399:r:IRS-mediated signalling", "R-RNO-9013424:r:RHOV GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-GGA-9013409:r:RHOJ GTPase cycle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-BTA-9845576:r:Glycosphingolipid transport", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-8853659:r:RET signaling", "R-CEL-114608:r:Platelet degranulation", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9696273:r:RND1 GTPase cycle", "R-GGA-6798695:r:Neutrophil degranulation", "R-DME-354192:r:Integrin signaling", "R-DME-110478:r:Insulin signaling pathway", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-XTR-192105:r:Synthesis of bile acids and bile salts", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-418555:r:G alpha (s) signalling events", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DDI-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-211163:r:AKT-mediated inactivation of FOXO1A", "R-HSA-9013420:r:RHOU GTPase cycle", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-112399:r:IRS-mediated signalling", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-DME-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-DME-190873:r:Gap junction degradation", "R-MMU-6811438:r:Intra-Golgi traffic", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-74713:r:IRS activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-8851805:r:MET activates RAS signaling", "R-BTA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-190873:r:Gap junction degradation", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-196025:r:Formation of annular gap junctions", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DME-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-112043:r:PLC beta mediated events", "R-RNO-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-74713:r:IRS activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-XTR-8980692:r:RHOA GTPase cycle", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-GGA-8980692:r:RHOA GTPase cycle", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DDI-4086398:r:Ca2+ pathway", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-8980692:r:RHOA GTPase cycle", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-912631:r:Regulation of signaling by CBL", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-DME-210993:r:Tie2 Signaling", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-9748787:r:Azathioprine ADME", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5635838:r:Activation of SMO", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-203615:r:eNOS activation", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-445144:r:Signal transduction by L1", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-HSA-165160:r:PDE3B signalling", "R-MMU-114608:r:Platelet degranulation", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-186763:r:Downstream signal transduction", "R-HSA-210990:r:PECAM1 interactions", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9845576:r:Glycosphingolipid transport", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SSC-74751:r:Insulin receptor signalling cascade", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-8854214:r:TBC/RABGAPs", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-167044:r:Signalling to RAS", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-DDI-2485179:r:Activation of the phototransduction cascade", "R-HSA-182971:r:EGFR downregulation", "R-CFA-8980692:r:RHOA GTPase cycle", "R-HSA-2424491:r:DAP12 signaling", "R-DME-196025:r:Formation of annular gap junctions", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8983432:r:Interleukin-15 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-SPO-192105:r:Synthesis of bile acids and bile salts", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-190873:r:Gap junction degradation", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-437239:r:Recycling pathway of L1", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-SPO-9013420:r:RHOU GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-DDI-9907900:r:Proteasome assembly", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-BTA-111933:r:Calmodulin induced events", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-8875656:r:MET receptor recycling", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-196025:r:Formation of annular gap junctions", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DME-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-201556:r:Signaling by ALK", "R-DME-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-211163:r:AKT-mediated inactivation of FOXO1A", "R-RNO-416476:r:G alpha (q) signalling events", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-165159:r:MTOR signalling", "R-DME-9607240:r:FLT3 Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-HSA-373752:r:Netrin-1 signaling", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DME-165159:r:MTOR signalling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-198693:r:AKT phosphorylates targets in the nucleus", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-MMU-74713:r:IRS activation", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DME-74749:r:Signal attenuation", "R-DDI-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-BTA-210993:r:Tie2 Signaling", "R-DRE-193648:r:NRAGE signals death through JNK", "R-SCE-1483166:r:Synthesis of PA", "R-MMU-418555:r:G alpha (s) signalling events", "R-CEL-6798695:r:Neutrophil degranulation", "R-CFA-9845576:r:Glycosphingolipid transport", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-MMU-8865999:r:MET activates PTPN11", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-8853659:r:RET signaling", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-DDI-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-1266695:r:Interleukin-7 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-SSC-74749:r:Signal attenuation", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-3928664:r:Ephrin signaling", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-DDI-202040:r:G-protein activation", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-1483148:r:Synthesis of PG", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-416476:r:G alpha (q) signalling events", "R-DDI-76005:r:Response to elevated platelet cytosolic Ca2+", "R-MMU-198203:r:PI3K/AKT activation", "R-DME-5635838:r:Activation of SMO", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-196025:r:Formation of annular gap junctions", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-SCE-9013420:r:RHOU GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-5621480:r:Dectin-2 family", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-203615:r:eNOS activation", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9748787:r:Azathioprine ADME", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-DDI-193648:r:NRAGE signals death through JNK", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-BTA-416476:r:G alpha (q) signalling events", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-418555:r:G alpha (s) signalling events", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DRE-9845576:r:Glycosphingolipid transport", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-9845576:r:Glycosphingolipid transport", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-354192:r:Integrin signaling", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DDI-416482:r:G alpha (12/13) signalling events", "R-CEL-196025:r:Formation of annular gap junctions", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2424491:r:DAP12 signaling", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-CFA-193648:r:NRAGE signals death through JNK", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DDI-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DME-9013409:r:RHOJ GTPase cycle", "R-CEL-6811438:r:Intra-Golgi traffic", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-1306955:r:GRB7 events in ERBB2 signaling", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-9614399:r:Regulation of localization of FOXO transcription factors", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-982772:r:Growth hormone receptor signaling", "R-SPO-9035034:r:RHOF GTPase cycle", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-165159:r:MTOR signalling", "R-BTA-8854214:r:TBC/RABGAPs", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1266695:r:Interleukin-7 signaling", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-167021:r:PLC-gamma1 signalling", "R-RNO-9607240:r:FLT3 Signaling", "R-DDI-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-114608:r:Platelet degranulation", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-211163:r:AKT-mediated inactivation of FOXO1A", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-DME-74751:r:Insulin receptor signalling cascade", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-CEL-165159:r:MTOR signalling", "R-SPO-389359:r:CD28 dependent Vav1 pathway", "R-GGA-9013420:r:RHOU GTPase cycle", "R-XTR-9013408:r:RHOG GTPase cycle", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-CEL-199418:r:Negative regulation of the PI3K/AKT network", "R-CEL-165158:r:Activation of AKT2", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9842663:r:Signaling by LTK", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-111933:r:Calmodulin induced events", "R-MMU-165158:r:Activation of AKT2", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-389513:r:Co-inhibition by CTLA4", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-912631:r:Regulation of signaling by CBL", "R-DME-112399:r:IRS-mediated signalling", "R-DME-112412:r:SOS-mediated signalling", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-182971:r:EGFR downregulation", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-DME-114604:r:GPVI-mediated activation cascade", "R-RNO-5635838:r:Activation of SMO", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9013424:r:RHOV GTPase cycle", "R-GGA-9013106:r:RHOC GTPase cycle", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-164944:r:Nef and signal transduction", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-DME-445095:r:Interaction between L1 and Ankyrins", "R-MMU-982772:r:Growth hormone receptor signaling", "R-HSA-8854521:r:Interaction between PHLDA1 and AURKA", "R-BTA-264876:r:Insulin processing", "R-RNO-418885:r:DCC mediated attractive signaling", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-165158:r:Activation of AKT2", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-8865999:r:MET activates PTPN11", "R-RNO-264876:r:Insulin processing", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-977443:r:GABA receptor activation", "R-RNO-111933:r:Calmodulin induced events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-BTA-114608:r:Platelet degranulation", "R-DDI-170670:r:Adenylate cyclase inhibitory pathway", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-XTR-9696264:r:RND3 GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-DDI-165158:r:Activation of AKT2", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-DDI-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-CEL-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-SSC-9607240:r:FLT3 Signaling", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-203615:r:eNOS activation", "R-GGA-416482:r:G alpha (12/13) signalling events", "R-CEL-9607240:r:FLT3 Signaling", "R-DRE-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9035034:r:RHOF GTPase cycle", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DME-193648:r:NRAGE signals death through JNK", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-977443:r:GABA receptor activation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-XTR-9013026:r:RHOB GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-9748787:r:Azathioprine ADME", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-DDI-418594:r:G alpha (i) signalling events", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-112399:r:IRS-mediated signalling", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-9706369:r:Negative regulation of FLT3", "R-BTA-180292:r:GAB1 signalosome", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-109704:r:PI3K Cascade", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-DDI-9648002:r:RAS processing", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-428540:r:Activation of RAC1", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SCE-389359:r:CD28 dependent Vav1 pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-1483166:r:Synthesis of PA", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-5621480:r:Dectin-2 family", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-373753:r:Nephrin family interactions", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-6811438:r:Intra-Golgi traffic", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-354192:r:Integrin signaling", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-CEL-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-8853659:r:RET signaling", "R-HSA-5635838:r:Activation of SMO", "R-DME-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8854521:r:Interaction between PHLDA1 and AURKA", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-DDI-9031628:r:NGF-stimulated transcription", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-211163:r:AKT-mediated inactivation of FOXO1A", "R-DDI-1489509:r:DAG and IP3 signaling", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-HSA-165158:r:Activation of AKT2", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-190873:r:Gap junction degradation", "R-RNO-109704:r:PI3K Cascade", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9842663:r:Signaling by LTK", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-9748787:r:Azathioprine ADME", "R-DME-180292:r:GAB1 signalosome", "R-RNO-1266695:r:Interleukin-7 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-9645135:r:STAT5 Activation", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8875656:r:MET receptor recycling", "R-RNO-182971:r:EGFR downregulation", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-GGA-9013026:r:RHOB GTPase cycle", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-416476:r:G alpha (q) signalling events", "R-RNO-1433559:r:Regulation of KIT signaling", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-8854521:r:Interaction between PHLDA1 and AURKA", "R-RNO-112412:r:SOS-mediated signalling", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5673000:r:RAF activation", "R-BTA-8875656:r:MET receptor recycling", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-DDI-445144:r:Signal transduction by L1", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DME-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-1483166:r:Synthesis of PA", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-111933:r:Calmodulin induced events", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-DME-418555:r:G alpha (s) signalling events", "R-DDI-165159:r:MTOR signalling", "R-HSA-8854214:r:TBC/RABGAPs", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-983189:r:Kinesins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-112412:r:SOS-mediated signalling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-109704:r:PI3K Cascade", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-8983432:r:Interleukin-15 signaling", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-BTA-109704:r:PI3K Cascade", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-201556:r:Signaling by ALK", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-MMU-74749:r:Signal attenuation", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-XTR-9013106:r:RHOC GTPase cycle", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-983189:r:Kinesins", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CEL-912631:r:Regulation of signaling by CBL", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-190873:r:Gap junction degradation", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SCE-192105:r:Synthesis of bile acids and bile salts", "R-DME-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-RNO-201556:r:Signaling by ALK", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-912631:r:Regulation of signaling by CBL", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-111933:r:Calmodulin induced events", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-SPO-9013424:r:RHOV GTPase cycle", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-DRE-446353:r:Cell-extracellular matrix interactions", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-RNO-977443:r:GABA receptor activation", "R-DME-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-MMU-203615:r:eNOS activation", "R-MMU-9845576:r:Glycosphingolipid transport", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-190873:r:Gap junction degradation", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-5635838:r:Activation of SMO", "R-MMU-202433:r:Generation of second messenger molecules", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SSC-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-XTR-9035034:r:RHOF GTPase cycle", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DDI-1483166:r:Synthesis of PA", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DRE-416476:r:G alpha (q) signalling events", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-9013026:r:RHOB GTPase cycle", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-DDI-202424:r:Downstream TCR signaling", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-375165:r:NCAM signaling for neurite out-growth"], "type": "Domain"}, "IPR001850": {"description": "Non-structural protein NS3, peptidase S7, flavivirus", "go_ids": ["GO:0003723", "GO:0003724", "GO:0005524"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003724:RNA helicase activity:F", "GO:0005524:ATP binding:F"], "name": "Flavi_NS3_S7", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR001851": {"description": "ABC transporter, permease", "go_ids": ["GO:0022857", "GO:0055085", "GO:0016020"], "go_terms": ["GO:0022857:transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P", "GO:0016020:membrane:C"], "name": "ABC_transp_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001852": {"description": "Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ", "go_ids": ["GO:0042823", "GO:0042819"], "go_terms": ["GO:0042823:pyridoxal 5'-phosphate biosynthetic process:P", "GO:0042819:vitamin B6 biosynthetic process:P"], "name": "PdxS/SNZ", "pathway_ids": ["PWY-6466"], "pathways": ["PWY-6466:t:pyridoxal 5'-phosphate biosynthesis II"], "type": "Family"}, "IPR001853": {"description": "DSBA-like thioredoxin domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "DSBA-like_thioredoxin_dom", "pathway_ids": ["R-RNO-9033241", "R-HSA-9760173", "R-RNO-156590", "R-MMU-9033241", "R-CEL-156590", "R-HSA-156590", "R-HSA-9033241", "R-MMU-156590"], "pathways": ["R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-9760173:r:Secretion of toxins", "R-RNO-156590:r:Glutathione conjugation", "R-MMU-9033241:r:Peroxisomal protein import", "R-CEL-156590:r:Glutathione conjugation", "R-HSA-156590:r:Glutathione conjugation", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-156590:r:Glutathione conjugation"], "type": "Domain"}, "IPR001854": {"description": "Large ribosomal subunit protein uL29", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uL29", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-DRE-9954709", "R-RNO-1799339", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-BTA-156827", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-DRE-9954714", "R-SCE-975956", "R-CEL-1799339", "R-SSC-9954714", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-SSC-1799339", "R-DRE-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-DDI-156827", "R-RNO-9954709", "R-SSC-72689", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DRE-975956", "R-BTA-9954716", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-HSA-156902", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-SSC-6791226", "R-BTA-9954709", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SSC-9954716", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001855": {"description": "Beta-defensin-like domain", "go_ids": ["GO:0005576", "GO:0006952"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006952:defense response:P"], "name": "Defensin_beta-like", "pathway_ids": ["R-BTA-1461973", "R-GGA-1461973", "R-SSC-1461957", "R-RNO-1461973", "R-GGA-1461957", "R-BTA-1461957", "R-MMU-1461957", "R-MMU-6798695", "R-MMU-1461973", "R-MMU-1462054", "R-HSA-1461957", "R-RNO-1461957", "R-HSA-1461973"], "pathways": ["R-BTA-1461973:r:Defensins", "R-GGA-1461973:r:Defensins", "R-SSC-1461957:r:Beta defensins", "R-RNO-1461973:r:Defensins", "R-GGA-1461957:r:Beta defensins", "R-BTA-1461957:r:Beta defensins", "R-MMU-1461957:r:Beta defensins", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-1461973:r:Defensins", "R-MMU-1462054:r:Alpha-defensins", "R-HSA-1461957:r:Beta defensins", "R-RNO-1461957:r:Beta defensins", "R-HSA-1461973:r:Defensins"], "type": "Domain"}, "IPR001857": {"description": "Large ribosomal subunit protein bL19", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bL19", "pathway_ids": ["R-HSA-5419276", "R-CEL-9937383", "R-MMU-9937383", "R-HSA-5368286", "R-CEL-5389840", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9937383", "R-CEL-5419276", "R-HSA-5389840", "R-DME-5389840", "R-MMU-5389840", "R-DME-9937383"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR001860": {"description": "Glycoside hydrolase, family 34", "go_ids": ["GO:0005975", "GO:0016020", "GO:0033644", "GO:0055036", "GO:0004308"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016020:membrane:C", "GO:0033644:host cell membrane:C", "GO:0055036:virion membrane:C", "GO:0004308:exo-alpha-sialidase activity:F"], "name": "Glyco_hydro_34", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168288", "R-HSA-168275", "R-HSA-168316", "R-HSA-168298", "R-HSA-168277", "R-HSA-168874", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-168298:r:Release", "R-HSA-168277:r:Influenza Virus Induced Apoptosis", "R-HSA-168874:r:Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Family"}, "IPR001863": {"description": "Glypican", "go_ids": ["GO:0031012", "GO:0009966", "GO:0005886"], "go_terms": ["GO:0031012:extracellular matrix:C", "GO:0009966:regulation of signal transduction:P", "GO:0005886:plasma membrane:C"], "name": "Glypican", "pathway_ids": ["R-XTR-1971475", "R-DME-381426", "R-DME-8957275", "R-MMU-2024096", "R-DME-5362798", "R-HSA-3560783", "R-DME-1971475", "R-HSA-9918485", "R-DRE-202733", "R-XTR-2024096", "R-HSA-3656237", "R-MMU-8957275", "R-RNO-2024096", "R-MMU-975634", "R-HSA-3656253", "R-HSA-5362798", "R-DRE-2024096", "R-RNO-8957275", "R-MMU-381426", "R-XTR-202733", "R-HSA-2024096", "R-MMU-2022928", "R-HSA-9833110", "R-HSA-2022928", "R-RNO-975634", "R-HSA-9918481", "R-HSA-381426", "R-XTR-2022928", "R-DME-2024096", "R-DRE-8957275", "R-HSA-376176", "R-HSA-1971475", "R-HSA-9694614", "R-HSA-3560801", "R-RNO-381426", "R-HSA-9820960", "R-DME-209471", "R-MMU-376176", "R-RNO-1971475", "R-DME-2022928", "R-MMU-5362798", "R-DRE-2022928", "R-DRE-381426", "R-HSA-4420332", "R-RNO-2022928", "R-HSA-8957275", "R-MMU-1971475", "R-HSA-202733", "R-HSA-975634", "R-DRE-1971475"], "pathways": ["R-XTR-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-MMU-2024096:r:HS-GAG degradation", "R-DME-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-DRE-202733:r:Cell surface interactions at the vascular wall", "R-XTR-2024096:r:HS-GAG degradation", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024096:r:HS-GAG degradation", "R-MMU-975634:r:Retinoid metabolism and transport", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-DRE-2024096:r:HS-GAG degradation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-XTR-202733:r:Cell surface interactions at the vascular wall", "R-HSA-2024096:r:HS-GAG degradation", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-XTR-2022928:r:HS-GAG biosynthesis", "R-DME-2024096:r:HS-GAG degradation", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-MMU-376176:r:Signaling by ROBO receptors", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-2022928:r:HS-GAG biosynthesis", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-DRE-2022928:r:HS-GAG biosynthesis", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-202733:r:Cell 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"R-MMU-75157", "R-HSA-9686347", "R-BTA-140534", "R-RNO-75153", "R-RNO-111465", "R-HSA-5357905", "R-HSA-5660668", "R-MMU-112409", "R-BTA-5675482", "R-HSA-9693928", "R-RNO-140534", "R-MMU-5218900", "R-MMU-3371378", "R-RNO-3371378", "R-MMU-168638", "R-HSA-75153", "R-MMU-111465", "R-RNO-5673001", "R-MMU-5673001", "R-MMU-5660668", "R-MMU-140534", "R-MMU-5357786", "R-BTA-5357905", "R-BTA-5218900", "R-RNO-2562578", "R-BTA-75157", "R-HSA-6803207", "R-HSA-5675482", "R-MMU-5675482", "R-HSA-9758274", "R-RNO-5660668", "R-RNO-75108", "R-HSA-75158", "R-HSA-5357786", "R-HSA-69416", "R-MMU-75153", "R-MMU-75108", "R-HSA-5213460", "R-MMU-75158", "R-HSA-5673001", "R-MMU-69416", "R-RNO-112409", "R-HSA-2562578", "R-RNO-69416", "R-RNO-5218900", "R-HSA-75157", "R-HSA-112409", "R-HSA-933543", "R-MMU-5357905", "R-MMU-264870", "R-HSA-111465", "R-BTA-3371378", "R-MMU-2562578", "R-HSA-140534", "R-RNO-168638", "R-HSA-264870", "R-MMU-9758274", "R-RNO-264870", "R-RNO-5675482", "R-HSA-3371378", "R-HSA-9013957", "R-BTA-2562578"], "pathways": ["R-BTA-69416:r:Dimerization of procaspase-8", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-75157:r:FasL/ CD95L signaling", "R-RNO-75158:r:TRAIL signaling", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-MMU-75157:r:FasL/ CD95L signaling", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-BTA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-RNO-75153:r:Apoptotic execution phase", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-112409:r:RAF-independent MAPK1/3 activation", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-MMU-3371378:r:Regulation by c-FLIP", "R-RNO-3371378:r:Regulation by c-FLIP", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-75153:r:Apoptotic execution phase", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-5218900:r:CASP8 activity is inhibited", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-BTA-75157:r:FasL/ CD95L signaling", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-5660668:r:CLEC7A/inflammasome pathway", "R-RNO-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-75158:r:TRAIL signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-69416:r:Dimerization of procaspase-8", "R-MMU-75153:r:Apoptotic execution phase", "R-MMU-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-75158:r:TRAIL signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-MMU-69416:r:Dimerization of procaspase-8", "R-RNO-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-RNO-69416:r:Dimerization of procaspase-8", "R-RNO-5218900:r:CASP8 activity is inhibited", "R-HSA-75157:r:FasL/ CD95L signaling", "R-HSA-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-3371378:r:Regulation by c-FLIP", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-3371378:r:Regulation by c-FLIP", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-BTA-2562578:r:TRIF-mediated programmed cell death"], "type": "Domain"}, "IPR001876": {"description": "Zinc finger, RanBP2-type", "go_ids": [], "go_terms": [], "name": "Znf_RanBP2", "pathway_ids": ["R-HSA-180910", "R-HSA-9020702", "R-HSA-168638", "R-HSA-2559580", "R-MMU-8941858", "R-MMU-198323", "R-BTA-5357786", "R-HSA-5689880", "R-MMU-9770562", "R-MMU-4570464", "R-RNO-3301854", "R-MMU-9020702", "R-MMU-6804756", "R-RNO-72163", "R-DRE-2559585", "R-DME-72163", "R-MMU-937072", "R-HSA-170822", "R-HSA-9918487", "R-MMU-5689896", "R-DRE-8941858", "R-MMU-68877", "R-MMU-937042", "R-DME-5689896", "R-DRE-445989", "R-MMU-5689880", "R-MMU-4551638", "R-CFA-2559585", "R-HSA-73776", "R-DME-72203", "R-CEL-110320", "R-HSA-450302", "R-HSA-4570464", "R-RNO-937042", "R-DME-75953", "R-DRE-937042", "R-HSA-1474228", "R-MMU-6804760", "R-DRE-450321", "R-MMU-110330", "R-HSA-5674400", "R-MMU-72163", "R-MMU-3301854", "R-RNO-975163", "R-HSA-141444", "R-MMU-450321", "R-HSA-975163", "R-MMU-170822", "R-HSA-6804760", "R-HSA-9609690", "R-SCE-917729", "R-RNO-6804760", "R-RNO-5689880", "R-DME-6804756", "R-HSA-159231", "R-HSA-3232142", "R-HSA-167161", "R-HSA-72163", "R-MMU-159227", "R-DRE-9766229", "R-HSA-6804756", "R-RNO-4085377", "R-RNO-6804757", "R-RNO-4570464", "R-CFA-399719", "R-MMU-5357905", "R-HSA-3232118", "R-RNO-8951664", "R-RNO-3232142", "R-MMU-3108214", "R-MMU-9766229", "R-DRE-6804757", "R-MMU-5663220", "R-HSA-9768919", "R-RNO-4615885", "R-MMU-3232142", "R-DRE-195253", "R-HSA-191859", "R-BTA-5357956", "R-BTA-195253", "R-DRE-2559580", "R-XTR-9770562", "R-HSA-9705671", "R-HSA-2467813", "R-CFA-6804757", "R-MMU-450302", "R-MMU-9645460", "R-RNO-937072", "R-DME-73779", "R-DRE-8953750", "R-DRE-8939243", "R-RNO-450321", "R-HSA-9636003", "R-MMU-5357956", "R-RNO-69541", "R-HSA-159227", "R-DME-9770562", "R-DME-73776", "R-HSA-937042", "R-HSA-5357905", "R-HSA-68877", "R-RNO-9645460", "R-HSA-165054", "R-CFA-6804760", "R-RNO-159236", "R-HSA-4615885", "R-HSA-167172", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-195253", "R-MMU-202424", "R-MMU-3371453", "R-HSA-195253", "R-HSA-72203", "R-HSA-399719", "R-HSA-9770562", "R-HSA-168271", "R-CEL-9755511", "R-RNO-9755511", "R-MMU-6804757", "R-SPO-917729", "R-RNO-159227", "R-DME-3301854", "R-HSA-5357956", "R-RNO-159231", "R-RNO-9770562", "R-HSA-5663220", "R-HSA-674695", "R-HSA-180746", "R-RNO-5357786", "R-HSA-76042", "R-SPO-72163", "R-BTA-5357905", "R-HSA-9725370", "R-MMU-2559585", "R-CEL-8951664", "R-HSA-73779", "R-MMU-8953750", "R-MMU-72203", "R-RNO-9020702", "R-HSA-9920588", "R-DRE-3232142", "R-MMU-5607764", "R-DME-76042", "R-MMU-2467813", "R-DRE-69541", "R-MMU-110320", "R-HSA-5689896", "R-DME-8951664", "R-HSA-9766229", "R-RNO-5357905", "R-DME-4085377", "R-RNO-3108214", "R-MMU-69541", "R-DRE-198323", "R-MMU-110331", "R-HSA-450321", "R-MMU-159230", "R-CFA-69541", "R-HSA-159230", "R-MMU-8951664", "R-RNO-159230", "R-HSA-110331", "R-MMU-445989", "R-HSA-3371453", "R-RNO-191859", "R-HSA-6804757", "R-HSA-75953", "R-RNO-202424", "R-DME-4615885", "R-MMU-975163", "R-DRE-9020702", "R-HSA-4551638", "R-MMU-1474228", "R-HSA-9610379", "R-DRE-6804756", "R-DME-3371453", "R-MMU-141444", "R-DME-674695", "R-RNO-72203", "R-DME-110320", "R-HSA-8941858", "R-HSA-6784531", "R-DME-159227", "R-HSA-168325", "R-HSA-9755511", "R-HSA-9648025", "R-MMU-2559580", "R-HSA-5357786", "R-MMU-159236", "R-DME-9755511", "R-HSA-3301854", "R-SPO-9770562", "R-HSA-8939243", "R-MMU-2871837", "R-HSA-5619107", "R-RNO-450302", "R-HSA-1251985", "R-RNO-445989", "R-BTA-9770562", "R-RNO-168638", "R-HSA-159236", "R-CFA-2559580", "R-MMU-399719", "R-RNO-983168", "R-RNO-2559585", "R-HSA-445989", "R-RNO-3371453", "R-HSA-3108214", "R-HSA-2559585", "R-DME-159236", "R-DME-159231", "R-CFA-8941858", "R-MMU-9755511", "R-HSA-1169408", "R-HSA-8953750", "R-DRE-450302", "R-DME-195253", "R-MMU-4615885", "R-HSA-198323", "R-CFA-5689880", "R-HSA-167162", "R-HSA-2871837", "R-MMU-4085377", "R-HSA-168333", "R-HSA-6794361", "R-HSA-9954709", "R-DRE-975163", "R-HSA-110329", "R-DRE-5689896", "R-RNO-6804756", "R-MMU-168638", "R-HSA-110330", "R-DRE-168638", "R-HSA-937072", "R-HSA-9918481", "R-HSA-5607764", "R-MMU-9648025", "R-SPO-72203", "R-HSA-8951664", "R-CFA-9766229", "R-MMU-2500257", "R-MMU-5357786", "R-HSA-2500257", "R-BTA-5689896", "R-HSA-168276", "R-DME-4551638", "R-HSA-110328", "R-HSA-4085377", "R-HSA-983168", "R-RNO-110320", "R-HSA-9645460", "R-MMU-8939243", "R-DME-159230", "R-RNO-4551638", "R-HSA-9629232", "R-RNO-2559580", "R-RNO-170822", "R-RNO-5607764", "R-XTR-195253", "R-HSA-9014325", "R-RNO-5357956", "R-CFA-6804756", "R-HSA-69541", "R-MMU-983168", "R-HSA-202424", "R-HSA-110320", "R-XTR-5689896", "R-RNO-2871837"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DRE-2559585:r:Oncogene Induced Senescence", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-DRE-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-CFA-2559585:r:Oncogene Induced Senescence", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-DRE-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9609690:r:HCMV Early Events", "R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-9766229:r:Degradation of CDH1", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-RNO-8951664:r:Neddylation", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-9766229:r:Degradation of CDH1", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-191859:r:snRNP Assembly", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-9770562:r:mRNA Polyadenylation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9636003:r:NEIL3-mediated resolution of ICLs", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-69541:r:Stabilization of p53", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-CFA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", 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"R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-209968:r:Thyroxine biosynthesis", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9824272:r:Somitogenesis", "R-BTA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-CFA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-8964038:r:LDL clearance", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-177929:r:Signaling by EGFR", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-DME-376176:r:Signaling by ROBO receptors", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-GGA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DME-177929:r:Signaling by EGFR", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DME-2243919:r:Crosslinking of collagen fibrils", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-428540:r:Activation of RAC1", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-BTA-8964026:r:Chylomicron clearance", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8964046:r:VLDL clearance", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-3000157:r:Laminin interactions", "R-RNO-8964038:r:LDL clearance", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-RNO-2024096:r:HS-GAG degradation", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9673240:r:Defective gamma-carboxylation of F9", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-CEL-216083:r:Integrin cell surface interactions", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-180292:r:GAB1 signalosome", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-HSA-9694614:r:Attachment and Entry", "R-RNO-1566948:r:Elastic fibre formation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-XTR-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9672383:r:Defective factor IX causes thrombophilia", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-166662:r:Lectin pathway of complement activation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-BTA-3000178:r:ECM proteoglycans", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-1566948:r:Elastic fibre formation", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-HSA-8964046:r:VLDL clearance", "R-RNO-114608:r:Platelet degranulation", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-RNO-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-2024096:r:HS-GAG degradation", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-DME-450728:r:Inhibition of actin polymerization", "R-BTA-2024101:r:CS/DS degradation", "R-BTA-159740:r:Gamma-carboxylation of protein precursors", "R-DME-180292:r:GAB1 signalosome", "R-RNO-209968:r:Thyroxine biosynthesis", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8963896:r:HDL assembly", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-2160916:r:Hyaluronan degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-BTA-8964038:r:LDL clearance", "R-MMU-8866376:r:Reelin signalling pathway", "R-RNO-1236394:r:Signaling by ERBB4", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-GGA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-RNO-182971:r:EGFR downregulation", "R-HSA-8866376:r:Reelin signalling pathway", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-CEL-376176:r:Signaling by ROBO receptors", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-5173105:r:O-linked glycosylation", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-177929:r:Signaling by EGFR", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-DME-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-GGA-8866376:r:Reelin signalling pathway", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-DME-390150:r:DS ligand bound to FT receptor", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-3359462:r:Defective AMN causes MGA1", "R-HSA-166663:r:Initial triggering of complement", "R-MMU-1566948:r:Elastic fibre formation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-DME-390023:r:Subcellular localisation of D", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DME-9013149:r:RAC1 GTPase cycle", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-182971:r:EGFR downregulation", "R-BTA-1566948:r:Elastic fibre formation", "R-CEL-2214320:r:Anchoring fibril formation", "R-CFA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-114608:r:Platelet degranulation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-DME-6809371:r:Formation of the cornified envelope", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-5173105:r:O-linked glycosylation", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-9758890:r:Transport of RCbl within the body", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-DME-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-DME-182971:r:EGFR downregulation", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-CFA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-373760:r:L1CAM interactions", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-3359463:r:Defective CUBN causes MGA1", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-1227986:r:Signaling by ERBB2", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-8964026:r:Chylomicron clearance", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9758890:r:Transport of RCbl within the body", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-HSA-9673218:r:Defective F9 secretion", "R-HSA-8964038:r:LDL clearance", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-CFA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-MMU-182971:r:EGFR downregulation", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-GGA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-8866376:r:Reelin signalling pathway", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-432142:r:Platelet sensitization by LDL", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-8964026:r:Chylomicron clearance", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-MMU-2214320:r:Anchoring fibril formation", "R-RNO-977606:r:Regulation of Complement cascade", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-RNO-9758890:r:Transport of RCbl within the body", "R-DME-2214320:r:Anchoring fibril formation", "R-HSA-2142845:r:Hyaluronan metabolism", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9629569:r:Protein hydroxylation", "R-CFA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-2024101:r:CS/DS degradation", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DME-1236394:r:Signaling by ERBB4", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-446203:r:Asparagine N-linked glycosylation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9673221:r:Defective F9 activation", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-9911233:r:Expression of NOTCH2NL genes", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-CEL-6809371:r:Formation of the cornified envelope", "R-HSA-8964011:r:HDL clearance", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000157:r:Laminin interactions", "R-DRE-2243919:r:Crosslinking of collagen fibrils", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-BTA-114608:r:Platelet degranulation", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-1236394:r:Signaling by ERBB4", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-MMU-8963896:r:HDL assembly", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9831926:r:Nephron development", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis"], "type": "Domain"}, "IPR001884": {"description": "Translation elongation factor IF5A-like", "go_ids": ["GO:0003723", "GO:0003746", "GO:0043022", "GO:0006414"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003746:translation elongation factor activity:F", "GO:0043022:ribosome binding:F", "GO:0006414:translational elongation:P"], "name": "IF5A-like", "pathway_ids": ["R-RNO-204626", "R-MMU-204626", "R-HSA-204626", "R-CEL-204626", "R-DRE-204626", "R-DDI-204626", "R-DME-204626", "R-SCE-204626", "R-GGA-204626", "R-SPO-204626", "R-BTA-204626"], "pathways": ["R-RNO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DRE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DDI-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DME-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SCE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-GGA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-BTA-204626:r:Hypusine synthesis from eIF5A-lysine"], "type": "Family"}, "IPR001885": {"description": "Lipoxygenase, mammalian", "go_ids": ["GO:0005506", "GO:0016702"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016702:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen:F"], "name": "LipOase_mml", "pathway_ids": ["PWY-6069", "PWY-5642", "PWY-6339", "PWY-6094", "PWY-7557", "PWY-6089", "PWY-8019", "PWY-7734", "PWY-7682", "PWY-6193", "PWY-5163", "PWY-8362", "PWY-6102", "PWY-8363", "PWY-6093", "PWY-6068", "PWY-6667", "PWY-8407", "PWY-8432", "PWY-7006", "PWY-6178", "PWY-7733", "PWY-7010", "PWY-7582", "PWY-6084", "PWY-6087", "PWY-181", "PWY-7009", "PWY-6107", "PWY-7011", "PWY-8431", "PWY-8260", "PWY-721", "PWY-6190", "PWY-8397", "PWY-8269", "PWY-6336", "R-HSA-6798695", "R-HSA-2142691", "R-HSA-2142700", "R-HSA-9018676", "R-RNO-9023661", "R-MMU-9027604", "R-RNO-2142688", "R-SSC-2142691", "R-MMU-9026286", "R-RNO-9025106", "R-HSA-9023661", "R-MMU-2142688", "R-HSA-9018896", "R-SSC-9025106", "R-SSC-9018681", "R-RNO-9027604", "R-HSA-9018677", "R-HSA-9026290", "R-BTA-2142712", "R-RNO-9018676", "R-MMU-9018676", "R-SSC-2142770", "R-BTA-9018896", "R-MMU-9025106", "R-BTA-2142691", "R-HSA-9026403", "R-RNO-2142770", "R-HSA-6785807", "R-RNO-9026286", "R-BTA-2142770", "R-MMU-2142770", "R-RNO-9018682", "R-SSC-9018677", "R-SSC-9023661", "R-BTA-9026286", "R-HSA-9012546", "R-RNO-9018677", "R-MMU-2142691", "R-HSA-9025106", "R-MMU-6798695", "R-HSA-2142770", "R-MMU-2142712", "R-RNO-6798695", "R-RNO-9018896", "R-BTA-9018681", "R-MMU-9018896", "R-MMU-2142696", "R-HSA-9018681", "R-BTA-9018677", "R-RNO-2142700", "R-MMU-9018681", "R-MMU-9023661", "R-HSA-2142712", "R-RNO-2142712", "R-HSA-2142696", "R-RNO-2142696", "R-HSA-9027604", "R-SSC-9018896", "R-SSC-9026286", "R-MMU-2142700", "R-MMU-9018682", "R-BTA-9023661", "R-MMU-9018677", "R-BTA-9025106", "R-RNO-9026290", "R-HSA-9020265", "R-RNO-9026403", "R-MMU-9026290", "R-HSA-2142688", "R-RNO-2142691", "R-MMU-9026403", "R-MMU-9020265", "R-RNO-9018681", "R-SSC-2142712", "R-HSA-9018682", "R-HSA-9026286", "R-RNO-9020265"], "pathways": ["PWY-6069:t:indigo biosynthesis", "PWY-5642:t:2,4-dinitrotoluene degradation", "PWY-6339:t:syringate degradation", "PWY-6094:t:3,4,6-trichlorocatechol degradation", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-6089:t:3-chlorocatechol degradation I (ortho)", "PWY-8019:t:2-hydroxyparaconate and itatartarate biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7682:t:arabidopyrone biosynthesis", "PWY-6193:t:3-chlorocatechol degradation II (ortho)", "PWY-5163:t:p-cumate degradation to 2-hydroxypentadienoate", "PWY-8362:t:photorespiration II", "PWY-6102:t:5-chloro-3-methyl-catechol degradation", "PWY-8363:t:photorespiration III", "PWY-6093:t:4,5-dichlorocatechol degradation", "PWY-6068:t:indican biosynthesis", "PWY-6667:t:resveratrol degradation", "PWY-8407:t:fumagillin biosynthesis", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-7006:t:4-amino-3-hydroxybenzoate degradation", "PWY-6178:t:2,4,6-trichlorophenol degradation", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7010:t:2-propylphenol degradation", "PWY-7582:t:mercaptosuccinate degradation", "PWY-6084:t:3,5-dichlorocatechol degradation", "PWY-6087:t:4-chlorocatechol degradation", "PWY-181:t:photorespiration I", "PWY-7009:t:2,2'-dihydroxybiphenyl degradation", "PWY-6107:t:chlorosalicylate degradation", "PWY-7011:t:2-isopropylphenol degradation", "PWY-8431:t:L-mimosine degradation", "PWY-8260:t:roxarsone degradation I", "PWY-721:t:3-methylquinoline degradation", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8269:t:methylarsonous acid detoxification III", "PWY-6336:t:protocatechuate degradation III (para-cleavage pathway)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-RNO-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-SSC-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-RNO-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-HSA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SSC-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-SSC-9018681:r:Biosynthesis of protectins", "R-RNO-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-HSA-9018677:r:Biosynthesis of DHA-derived SPMs", "R-HSA-9026290:r:Biosynthesis of DPAn-3-derived maresins", "R-BTA-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-SSC-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9026403:r:Biosynthesis of DPAn-3-derived 13-series resolvins", "R-RNO-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-BTA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-MMU-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-RNO-9018682:r:Biosynthesis of maresins", "R-SSC-9018677:r:Biosynthesis of DHA-derived SPMs", "R-SSC-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-BTA-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-HSA-9012546:r:Interleukin-18 signaling", "R-RNO-9018677:r:Biosynthesis of DHA-derived SPMs", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-MMU-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-9018896:r:Biosynthesis of 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"R-MMU-9018682:r:Biosynthesis of maresins", "R-BTA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9018677:r:Biosynthesis of DHA-derived SPMs", "R-BTA-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-RNO-9026290:r:Biosynthesis of DPAn-3-derived maresins", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9026403:r:Biosynthesis of DPAn-3-derived 13-series resolvins", "R-MMU-9026290:r:Biosynthesis of DPAn-3-derived maresins", "R-HSA-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9026403:r:Biosynthesis of DPAn-3-derived 13-series resolvins", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9018681:r:Biosynthesis of protectins", "R-SSC-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-HSA-9018682:r:Biosynthesis of maresins", "R-HSA-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-RNO-9020265:r:Biosynthesis of 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[], "pathways": [], "type": "Domain"}, "IPR001891": {"description": "Malic oxidoreductase", "go_ids": ["GO:0004470", "GO:0016616"], "go_terms": ["GO:0004470:malic enzyme activity:F", "GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "Malic_OxRdtase", "pathway_ids": ["PWY-3641", "PWY-7115", "PWY-7384", "PWY-7686", "PWY-7118", "R-MMU-70268", "R-HSA-1989781", "R-HSA-9818025", "R-MMU-9837999", "R-RNO-70268", "R-MMU-9861718", "R-HSA-9837999", "R-RNO-9861718", "R-HSA-70268", "R-HSA-9861718"], "pathways": ["PWY-3641:t:L-carnitine degradation II", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-7686:t:L-malate degradation II", "PWY-7118:t:chitin deacetylation", "R-MMU-70268:r:Pyruvate metabolism", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9818025:r:NFE2L2 regulating TCA cycle genes", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-70268:r:Pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism"], "type": "Family"}, "IPR001892": {"description": "Small ribosomal subunit protein uS13", "go_ids": ["GO:0003723", "GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uS13", "pathway_ids": ["R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553", "R-CFA-1799339", "R-SPO-975957", "R-CFA-72695", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-HSA-72695", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-BTA-72689", "R-MMU-9954716", "R-CFA-72702", "R-RNO-9954716", "R-SCE-6791226", "R-CFA-72706", "R-DDI-9954714", "R-BTA-72695", 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activation", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-8851805:r:MET activates RAS signaling", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-MMU-354192:r:Integrin signaling", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-SCE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-354192:r:Integrin signaling", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-112412:r:SOS-mediated signalling", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-112412:r:SOS-mediated signalling", "R-DDI-392517:r:Rap1 signalling", "R-DME-167044:r:Signalling to RAS", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-74749:r:Signal attenuation", "R-HSA-9842663:r:Signaling by LTK", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-DME-74749:r:Signal attenuation", "R-XTR-354192:r:Integrin signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-186763:r:Downstream signal transduction", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-74749:r:Signal attenuation", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-354192:r:Integrin signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-9607240:r:FLT3 Signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DME-912631:r:Regulation of signaling by CBL", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-RNO-392517:r:Rap1 signalling", "R-DME-210993:r:Tie2 Signaling", "R-DME-2424491:r:DAP12 signaling", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-XTR-1169092:r:Activation of RAS in B cells", "R-BTA-392517:r:Rap1 signalling", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-XTR-392517:r:Rap1 signalling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-210993:r:Tie2 Signaling", "R-MMU-8853659:r:RET signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-SCE-354192:r:Integrin signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-9035034:r:RHOF GTPase cycle", "R-DME-8853659:r:RET signaling", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-354192:r:Integrin signaling", "R-CEL-186763:r:Downstream signal transduction", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-SCE-392517:r:Rap1 signalling", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-MMU-1169092:r:Activation of RAS in B cells", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-167044:r:Signalling to RAS", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-MMU-422356:r:Regulation of insulin secretion", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-9842663:r:Signaling by LTK", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-1169092:r:Activation of RAS in B cells", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-SCE-9013424:r:RHOV GTPase cycle", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-171007:r:p38MAPK events", "R-HSA-354192:r:Integrin signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-171007:r:p38MAPK events", "R-DDI-171007:r:p38MAPK events", "R-DDI-3295583:r:TRP channels", "R-CEL-392517:r:Rap1 signalling", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-1169092:r:Activation of RAS in B cells", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-1169092:r:Activation of RAS in B cells", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3"], "type": "Domain"}, "IPR001896": {"description": "Plant virus coat protein", "go_ids": [], "go_terms": [], "name": "Plant_vir_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001898": {"description": "Solute carrier family 13", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "SLC13A/DASS", "pathway_ids": ["R-RNO-9955298", "R-DME-433137", "R-CEL-433137", "R-RNO-433137", "R-CEL-9955298", "R-HSA-433137", "R-DME-9955298", "R-HSA-9955298", "R-MMU-9955298", "R-MMU-433137"], "pathways": ["R-RNO-9955298:r:SLC-mediated transport of organic anions", "R-DME-433137:r:Sodium-coupled sulphate, di- and tri-carboxylate transporters", "R-CEL-433137:r:Sodium-coupled sulphate, di- and tri-carboxylate transporters", "R-RNO-433137:r:Sodium-coupled sulphate, di- and tri-carboxylate transporters", "R-CEL-9955298:r:SLC-mediated transport of organic anions", "R-HSA-433137:r:Sodium-coupled sulphate, di- and tri-carboxylate transporters", "R-DME-9955298:r:SLC-mediated transport of organic anions", "R-HSA-9955298:r:SLC-mediated transport of organic anions", "R-MMU-9955298:r:SLC-mediated transport of organic anions", "R-MMU-433137:r:Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "type": "Family"}, "IPR001900": {"description": "Ribonuclease II/R", "go_ids": ["GO:0003723", "GO:0004540"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0004540:RNA nuclease activity:F"], "name": "RNase_II/R", "pathway_ids": ["R-MMU-9930044", "R-HSA-1989781", "R-MMU-6791226", "R-MMU-450385", "R-HSA-9930044", "R-HSA-2151201", "R-CEL-450385", "R-SCE-450513", "R-HSA-381340", "R-MMU-429958", "R-HSA-9707616", "R-HSA-9931509", "R-SPO-9930044", "R-CEL-450513", "R-HSA-1368108", "R-SCE-450385", "R-HSA-9820865", "R-HSA-450385", "R-SCE-429958", "R-HSA-380994", "R-MMU-450513", "R-CEL-429958", "R-MMU-450604", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-6791226", "R-HSA-450513", "R-HSA-400206", "R-HSA-450604", "R-CEL-9930044", "R-HSA-429958", "R-SPO-429958", "R-MMU-400206", "R-MMU-9707564", "R-HSA-2426168"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9707616:r:Heme signaling", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-SPO-9930044:r:Nuclear RNA decay", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR001901": {"description": "Protein translocase complex, SecE/Sec61-gamma subunit", "go_ids": ["GO:0006605", "GO:0006886", "GO:0016020"], "go_terms": ["GO:0006605:protein targeting:P", "GO:0006886:intracellular protein transport:P", "GO:0016020:membrane:C"], "name": "Translocase_SecE/Sec61-g", "pathway_ids": ["R-HSA-1799339", "R-CEL-9609523", "R-SPO-9609523", "R-CFA-9609523", "R-DDI-9609523", "R-DME-9609523", "R-HSA-1236974", "R-HSA-9760173", "R-MMU-9609523", "R-SCE-9609523", "R-HSA-9609523", "R-HSA-1222387", "R-BTA-9609523"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CFA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-9760173:r:Secretion of toxins", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Family"}, "IPR001902": {"description": "SLC26A/SulP transporter", "go_ids": ["GO:0016020", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "SLC26A/SulP_fam", "pathway_ids": ["R-SCE-427601", "R-CEL-427601", "R-HSA-3560792", "R-SPO-427601", "R-BTA-174362", "R-SCE-174362", "R-HSA-5619085", "R-HSA-9662361", "R-BTA-427601", "R-HSA-5619046", "R-RNO-427601", "R-SPO-174362", "R-CEL-174362", "R-HSA-427601", "R-DRE-427601", "R-MMU-174362", "R-HSA-174362", "R-MMU-427601", "R-RNO-174362"], "pathways": ["R-SCE-427601:r:Inorganic anion exchange by SLC26 transporters", "R-CEL-427601:r:Inorganic anion exchange by SLC26 transporters", "R-HSA-3560792:r:Defective SLC26A2 causes chondrodysplasias", "R-SPO-427601:r:Inorganic anion exchange by SLC26 transporters", "R-BTA-174362:r:Transport and metabolism of PAPS", "R-SCE-174362:r:Transport and metabolism of PAPS", "R-HSA-5619085:r:Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-BTA-427601:r:Inorganic anion exchange by SLC26 transporters", "R-HSA-5619046:r:Defective SLC26A4 causes Pendred syndrome (PDS)", "R-RNO-427601:r:Inorganic anion exchange by SLC26 transporters", "R-SPO-174362:r:Transport and metabolism of PAPS", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-HSA-427601:r:Inorganic anion exchange by SLC26 transporters", "R-DRE-427601:r:Inorganic anion exchange by SLC26 transporters", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-MMU-427601:r:Inorganic anion exchange by SLC26 transporters", "R-RNO-174362:r:Transport and metabolism of PAPS"], "type": "Family"}, "IPR001903": {"description": "Spike glycoprotein fusion domain, Rhabdovirus", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Rhabdo_glycop_FD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001905": {"description": "Ammonium transporter", "go_ids": ["GO:0008519", "GO:0016020", "GO:0072488"], "go_terms": ["GO:0008519:ammonium channel activity:F", "GO:0016020:membrane:C", "GO:0072488:ammonium transmembrane transport:P"], "name": "Ammonium_transpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001906": {"description": "Terpene synthase, N-terminal domain", "go_ids": ["GO:0010333", "GO:0016829"], "go_terms": ["GO:0010333:terpene synthase activity:F", "GO:0016829:lyase activity:F"], "name": "Terpene_synth_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001907": {"description": "ATP-dependent Clp protease proteolytic subunit", "go_ids": ["GO:0004252", "GO:0006508", "GO:0004176"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0004176:ATP-dependent peptidase activity:F"], "name": "ClpP", "pathway_ids": ["R-CEL-9837999", "R-HSA-9837999", "R-BTA-9837999", "R-MMU-9837999"], "pathways": ["R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation"], "type": "Family"}, "IPR001909": {"description": "Krueppel-associated box", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "KRAB", "pathway_ids": ["R-MMU-9843940", "R-MMU-3214841", "R-MMU-212436", "R-MMU-77588", "R-MMU-73856", "R-HSA-73856", "R-RNO-3214841", "R-HSA-3214841", "R-HSA-6803204", "R-HSA-77588", "R-HSA-912446", "R-HSA-111367", "R-MMU-111367", "R-RNO-212436", "R-RNO-9843940", "R-HSA-9843940", "R-HSA-3899300", "R-HSA-212436", "R-BTA-212436"], "pathways": ["R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-212436:r:Generic Transcription Pathway", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-912446:r:Meiotic recombination", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-RNO-212436:r:Generic Transcription Pathway", "R-RNO-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Domain"}, "IPR001910": {"description": "Inosine/uridine-preferring nucleoside hydrolase domain", "go_ids": ["GO:0016799"], "go_terms": ["GO:0016799:hydrolase activity, hydrolyzing N-glycosyl compounds:F"], "name": "Inosine/uridine_hydrolase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001911": {"description": "Small ribosomal subunit protein bS21", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bS21", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR001912": {"description": "Small ribosomal subunit protein uS4, N-terminal", "go_ids": ["GO:0019843"], "go_terms": ["GO:0019843:rRNA binding:F"], "name": "Ribosomal_uS4_N", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-DME-6791226", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-HSA-72695", "R-BTA-72689", "R-DME-72706", "R-RNO-72695", "R-HSA-975956", "R-MMU-72706", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-CEL-72706", "R-BTA-72695", "R-CEL-6791226", "R-CEL-9954714", "R-CEL-9954716", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-BTA-156827", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-BTA-6791226", "R-SPO-72706", "R-SCE-975956", "R-DDI-72695", "R-CEL-1799339", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-CEL-156827", "R-RNO-72649", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-DDI-72702", "R-DDI-72689", "R-SPO-72689", "R-CEL-72689", "R-MMU-1799339", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", "R-SCE-72706", "R-DDI-6791226", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-RNO-72706", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-6790901", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-DME-72695", "R-DME-975957", "R-BTA-9954716", "R-MMU-72702", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", 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cytosol", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin 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"R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-72649:r:Translation initiation complex formation", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR001913": {"description": "Equine arteritis virus GP2b envelope glycoprotein", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Equi_arteri_GP2b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001915": {"description": "Peptidase M48", "go_ids": ["GO:0004222", "GO:0006508"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_M48", "pathway_ids": ["PWY-8119", "R-SCE-9840373", "R-HSA-9840373", "R-SCE-169911", "R-SPO-169911", "R-HSA-169911", "R-BTA-169911", "R-SPO-9840373", "R-RNO-9840373", "R-HSA-9837999", "R-DRE-9840373", "R-RNO-169911", "R-MMU-169911", "R-MMU-9840373", "R-DRE-169911", "R-BTA-9840373"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-SCE-169911:r:Regulation of Apoptosis", "R-SPO-169911:r:Regulation of Apoptosis", "R-HSA-169911:r:Regulation of Apoptosis", "R-BTA-169911:r:Regulation of Apoptosis", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DRE-9840373:r:Cellular response to mitochondrial stress", "R-RNO-169911:r:Regulation of Apoptosis", "R-MMU-169911:r:Regulation of Apoptosis", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-DRE-169911:r:Regulation of Apoptosis", "R-BTA-9840373:r:Cellular response to mitochondrial stress"], "type": "Domain"}, "IPR001916": {"description": "Glycoside hydrolase, family 22", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_22", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-DDI-6798695", "R-SSC-6798695", "R-RNO-6803157", "R-BTA-6803157", "R-DME-6798695", "R-HSA-977225", "R-BTA-6798695", "R-HSA-5653890", "R-GGA-6798695", "R-DME-6803157", "R-SSC-5653890", "R-GGA-6803157", "R-MMU-5653890", "R-CFA-6803157", "R-SSC-6803157", "R-HSA-6803157", "R-MMU-6798695", "R-MMU-6803157", "R-CFA-6798695", "R-DDI-6803157", "R-GGA-5653890", "R-HSA-9927426"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-6803157:r:Antimicrobial peptides", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-5653890:r:Lactose synthesis", "R-GGA-6798695:r:Neutrophil degranulation", "R-DME-6803157:r:Antimicrobial peptides", "R-SSC-5653890:r:Lactose synthesis", "R-GGA-6803157:r:Antimicrobial peptides", "R-MMU-5653890:r:Lactose synthesis", "R-CFA-6803157:r:Antimicrobial peptides", "R-SSC-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-6803157:r:Antimicrobial peptides", "R-CFA-6798695:r:Neutrophil degranulation", "R-DDI-6803157:r:Antimicrobial peptides", "R-GGA-5653890:r:Lactose synthesis", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Family"}, "IPR001919": {"description": "Carbohydrate-binding type-2 domain", "go_ids": ["GO:0004553", "GO:0005975", "GO:0030246"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0030246:carbohydrate binding:F"], "name": "CBD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001920": {"description": "Asp/Glu racemase", "go_ids": ["GO:0016855"], "go_terms": ["GO:0016855:racemase and epimerase activity, acting on amino acids and derivatives:F"], "name": "Asp/Glu_race", "pathway_ids": ["PWY-6387", "PWY-6386"], "pathways": ["PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "type": "Homologous_superfamily"}, "IPR001925": {"description": "Porin, eukaryotic type", "go_ids": ["GO:0005741", "GO:0008308", "GO:0098656"], "go_terms": ["GO:0005741:mitochondrial outer membrane:C", "GO:0008308:voltage-gated monoatomic anion channel activity:F", "GO:0098656:monoatomic anion transmembrane transport:P"], "name": "Porin_Euk", "pathway_ids": ["R-MMU-70268", "R-RNO-5205685", "R-BTA-5689880", "R-SSC-5205685", "R-HSA-5689880", "R-BTA-5205685", "R-SSC-70268", "R-SPO-70268", "R-CEL-5205685", "R-MMU-5205685", "R-RNO-5689880", "R-HSA-70268", "R-BTA-70268", "R-MMU-5689880", "R-DME-70268", "R-CEL-70268", "R-HSA-8949215", "R-RNO-70268", "R-DME-5205685", "R-DDI-70268", "R-HSA-1268020", "R-SSC-5689880", "R-HSA-5205685", "R-SCE-5205685", "R-DME-5689880", "R-SCE-70268"], "pathways": ["R-MMU-70268:r:Pyruvate metabolism", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-5689880:r:Ub-specific processing proteases", "R-SSC-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SSC-70268:r:Pyruvate metabolism", "R-SPO-70268:r:Pyruvate metabolism", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-70268:r:Pyruvate metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-RNO-70268:r:Pyruvate metabolism", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DDI-70268:r:Pyruvate metabolism", "R-HSA-1268020:r:Mitochondrial protein import", "R-SSC-5689880:r:Ub-specific processing proteases", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SCE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DME-5689880:r:Ub-specific processing proteases", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Family"}, "IPR001926": {"description": "Tryptophan synthase beta chain-like, PALP domain", "go_ids": [], "go_terms": [], "name": "TrpB-like_PALP", "pathway_ids": ["R-DDI-1614603", "R-DDI-977347", "R-MMU-977347", "R-CEL-1614603", "R-SPO-977347", "R-RNO-977347", "R-DDI-8849175", "R-MMU-8849175", "R-HSA-2408508", "R-HSA-1614603", "R-HSA-977347", "R-MTU-936721", "R-BTA-977347", "R-MMU-1614603", "R-HSA-8849175", "R-SCE-1614603", "R-MTU-936654", "R-SCE-8849175", "R-SCE-977347", "R-RNO-8849175", "R-RNO-1614603"], "pathways": ["R-DDI-1614603:r:Cysteine formation from homocysteine", "R-DDI-977347:r:Serine metabolism", "R-MMU-977347:r:Serine metabolism", "R-CEL-1614603:r:Cysteine formation from homocysteine", "R-SPO-977347:r:Serine metabolism", "R-RNO-977347:r:Serine metabolism", "R-DDI-8849175:r:Threonine catabolism", "R-MMU-8849175:r:Threonine catabolism", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-HSA-1614603:r:Cysteine formation from homocysteine", "R-HSA-977347:r:Serine metabolism", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine", "R-BTA-977347:r:Serine metabolism", "R-MMU-1614603:r:Cysteine formation from homocysteine", "R-HSA-8849175:r:Threonine catabolism", "R-SCE-1614603:r:Cysteine formation from homocysteine", "R-MTU-936654:r:Cysteine synthesis from O-phosphoserine", "R-SCE-8849175:r:Threonine catabolism", "R-SCE-977347:r:Serine metabolism", "R-RNO-8849175:r:Threonine catabolism", "R-RNO-1614603:r:Cysteine formation from homocysteine"], "type": "Domain"}, "IPR001927": {"description": "Sodium:galactoside symporter", "go_ids": ["GO:0006814", "GO:0016020"], "go_terms": ["GO:0006814:sodium ion transport:P", "GO:0016020:membrane:C"], "name": "Na/Gal_symport", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR001928": {"description": "Endothelin-like toxin", "go_ids": ["GO:0005576", "GO:0019229"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019229:regulation of vasoconstriction:P"], "name": "Endothln-like_toxin", "pathway_ids": ["R-MMU-416476", "R-CFA-375276", "R-SSC-375276", "R-RNO-375276", "R-HSA-375276", "R-CFA-416476", "R-MMU-375276", "R-HSA-9856649", "R-HSA-416476", "R-RNO-416476", "R-SSC-416476", "R-BTA-375276", "R-BTA-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-CFA-375276:r:Peptide ligand-binding receptors", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-CFA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-SSC-416476:r:G alpha (q) signalling events", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-BTA-416476:r:G alpha (q) signalling events"], "type": "Domain"}, "IPR001929": {"description": "Germin", "go_ids": ["GO:0030145"], "go_terms": ["GO:0030145:manganese ion binding:F"], "name": "Germin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001931": {"description": "Small ribosomal subunit protein eS21", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eS21", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-DME-72706", "R-HSA-72695", "R-BTA-72689", "R-HSA-975956", "R-MMU-72706", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-XTR-9954716", "R-CEL-72706", "R-BTA-72695", "R-XTR-1799339", "R-CEL-9954716", "R-CEL-9954714", "R-SCE-72702", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-BTA-156827", "R-MMU-6791226", "R-RNO-156827", "R-DRE-9954714", "R-SPO-72706", "R-BTA-6791226", "R-XTR-9954714", "R-SSC-9954714", "R-CEL-1799339", "R-SCE-975956", "R-DDI-72695", "R-DRE-72695", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-CEL-156827", "R-RNO-72649", "R-RNO-6791226", "R-SSC-1799339", "R-DRE-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-DDI-156827", "R-SSC-72689", "R-CEL-72649", "R-SPO-156827", "R-XTR-72706", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-CEL-72689", "R-SPO-72689", "R-DDI-72702", 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"R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72649:r:Translation initiation complex formation", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-72649:r:Translation initiation complex formation", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR001932": {"description": "PPM-type phosphatase-like domain", "go_ids": [], "go_terms": [], "name": "PPM-type_phosphatase-like_dom", "pathway_ids": ["R-MMU-2173795", "R-HSA-9020702", "R-HSA-9705671", "R-HSA-168638", "R-HSA-9700645", "R-MMU-380972", "R-HSA-937042", "R-HSA-5689880", "R-SPO-5223345", "R-MMU-450302", "R-RNO-1169408", "R-MMU-5607764", "R-MMU-9645460", "R-MMU-9020702", "R-MMU-937072", "R-HSA-1169408", "R-MMU-5357956", "R-MMU-937042", "R-BTA-380972", "R-HSA-450321", "R-SPO-9013106", "R-HSA-2871837", "R-RNO-2173795", "R-MMU-5689880", "R-MMU-445989", "R-BTA-204174", "R-MMU-70895", "R-HSA-199418", "R-HSA-2173795", "R-HSA-450302", "R-SPO-983168", "R-MMU-975163", "R-HSA-8878166", "R-BTA-2173795", "R-MMU-168638", "R-SPO-6803207", "R-HSA-9617324", "R-HSA-937072", "R-HSA-5607764", "R-HSA-380972", "R-RNO-199418", "R-CEL-2173795", "R-BTA-70895", "R-HSA-204174", "R-RNO-204174", "R-HSA-445989", "R-CEL-380972", "R-MMU-450321", "R-HSA-1660661", "R-MMU-1169408", "R-HSA-9645460", "R-HSA-70895", "R-MMU-8878166", "R-CEL-6803207", "R-RNO-70895", "R-SPO-8980692", "R-SPO-9652282", "R-MMU-204174", "R-CEL-1169408", "R-HSA-5357956", "R-MMU-2871837", "R-RNO-380972", "R-SPO-199418", "R-HSA-9014325", "R-MMU-199418", "R-BTA-1169408", "R-HSA-9912529", "R-HSA-9725370", "R-HSA-975163"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SPO-5223345:r:Miscellaneous transport and binding events", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-CEL-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Domain"}, "IPR001936": {"description": "Ras GTPase-activating domain", "go_ids": ["GO:0043087"], "go_terms": ["GO:0043087:regulation of GTPase activity:P"], "name": "RasGAP_dom", "pathway_ids": ["R-HSA-6798695", "R-DDI-5218921", "R-MMU-8856828", "R-HSA-9013409", "R-HSA-5674135", "R-HSA-6802952", "R-MMU-9013106", "R-HSA-8856828", "R-DME-5658442", "R-MMU-9013408", "R-HSA-9013424", "R-MMU-9013404", "R-DDI-5626467", "R-HSA-3928662", "R-HSA-8849471", "R-SPO-9013106", "R-MMU-9013420", "R-SCE-8980692", "R-HSA-9649948", "R-SCE-9013420", "R-HSA-9013408", "R-SCE-9696273", "R-HSA-6802955", "R-SPO-5626467", "R-HSA-373753", "R-DDI-6798695", "R-HSA-6802948", "R-DDI-5658442", "R-HSA-8876198", "R-HSA-9696264", "R-HSA-5218921", "R-SPO-8980692", "R-HSA-9013404", "R-HSA-9013149", "R-MMU-373753", "R-HSA-8980692", "R-DDI-5674135", "R-HSA-5658442", "R-MMU-8876198", "R-HSA-381676", "R-MMU-9013406", "R-SPO-9013424", "R-HSA-9013026", "R-MMU-6798695", "R-HSA-9656223", "R-SPO-6798695", "R-MMU-5674135", "R-HSA-5626467", "R-MMU-8980692", "R-SCE-6798695", "R-DDI-8849471", "R-HSA-9013106", "R-DDI-9013149", "R-SPO-9013406", "R-SCE-5626467", "R-SCE-9013406", "R-CEL-8876198", "R-HSA-6802946", "R-HSA-9013148", "R-RNO-3928662", "R-DME-8856828", "R-MMU-5658442", "R-BTA-8876198", "R-SPO-9013420", "R-SCE-9013424", "R-HSA-6802953", "R-BTA-8856828", "R-CEL-8856828", "R-RNO-8849471", "R-HSA-9013420", "R-MMU-5626467", "R-DME-8876198", "R-MMU-9013424", "R-SCE-9013106", "R-HSA-186763", "R-RNO-5218921", "R-RNO-5658442", "R-DDI-9013404", "R-HSA-9013406", "R-MMU-9013149", "R-RNO-186763", "R-HSA-9696273"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-SPO-9013106:r:RHOC GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-SCE-9013420:r:RHOU GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SCE-9696273:r:RND1 GTPase cycle", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SPO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-373753:r:Nephrin family interactions", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-373753:r:Nephrin family interactions", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-9013424:r:RHOV GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-SCE-5626467:r:RHO GTPases activate IQGAPs", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-9013420:r:RHOU GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013420:r:RHOU GTPase cycle", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SCE-9013106:r:RHOC GTPase cycle", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR001937": {"description": "Galactose-1-phosphate uridyl transferase, class I", "go_ids": ["GO:0008108", "GO:0008270", "GO:0006012"], "go_terms": ["GO:0008108:UDP-glucose:hexose-1-phosphate uridylyltransferase activity:F", "GO:0008270:zinc ion binding:F", "GO:0006012:galactose metabolic process:P"], "name": "GalP_UDPtransf1", "pathway_ids": ["PWY-6527", "PWY-6317", "R-HSA-70370", "R-MMU-70370", "R-RNO-70370", "R-DME-70370", "R-HSA-5609978", "R-CEL-70370"], "pathways": ["PWY-6527:t:stachyose degradation", "PWY-6317:t:D-galactose degradation I (Leloir pathway)", "R-HSA-70370:r:Galactose catabolism", "R-MMU-70370:r:Galactose catabolism", "R-RNO-70370:r:Galactose catabolism", "R-DME-70370:r:Galactose catabolism", "R-HSA-5609978:r:Defective GALT can cause GALCT", "R-CEL-70370:r:Galactose catabolism"], "type": "Family"}, "IPR001938": {"description": "Thaumatin family", "go_ids": [], "go_terms": [], "name": "Thaumatin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR001943": {"description": "UVR domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "UVR_dom", "pathway_ids": ["R-RNO-9013026", "R-HSA-8980692", "R-MMU-9013106", "R-MMU-9013026", "R-MMU-8980692", "R-RNO-8980692", "R-HSA-9013026", "R-RNO-9013106", "R-HSA-9013106"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle"], "type": "Domain"}, "IPR001944": {"description": "Glycoside hydrolase, family 35", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glycoside_Hdrlase_35", "pathway_ids": ["PWY-6807", "R-DDI-9840310", "R-MMU-9840310", "R-HSA-2024101", "R-HSA-9953111", "R-HSA-6798695", "R-DDI-6798695", "R-RNO-9840310", "R-HSA-9840310", "R-HSA-2022857", "R-RNO-2022857", 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"R-DME-5689901", "R-DME-202424", "R-DME-187577", "R-HSA-201681", "R-SSC-450408", "R-DME-72649", "R-HSA-3785653", "R-BTA-4608870", "R-SSC-1358803", "R-MMU-349425", "R-DME-9770562", "R-BTA-2871837", "R-BTA-174154", "R-MMU-2672351", "R-DDI-69601", "R-CFA-6804760", "R-BTA-8866427", "R-DME-8863795", "R-DDI-5689880", "R-CFA-8849469", "R-MMU-5696400", "R-SSC-8941858", "R-BTA-8849469", "R-CFA-9954716", "R-MMU-209560", "R-CEL-9755511", "R-BTA-5696394", "R-CFA-201681", "R-MMU-5675482", "R-MMU-5656169", "R-HSA-72764", "R-BTA-9929356", "R-BTA-4641263", "R-SSC-187577", "R-MMU-5676590", "R-SSC-9648002", "R-HSA-5357956", "R-BTA-5656121", "R-RNO-5654733", "R-CFA-3134975", "R-DME-6782210", "R-CFA-174178", "R-HSA-9725370", "R-HSA-8849469", "R-MMU-5632684", "R-SSC-5675221", "R-BTA-5610785", "R-SSC-5655862", "R-SSC-4641263", "R-MMU-2467813", "R-MMU-2173791", "R-BTA-9824878", "R-DDI-5693565", "R-CEL-917729", "R-BTA-9033241", "R-DME-174113", "R-CFA-9664873", "R-BTA-9758274", "R-DDI-9954714", "R-BTA-5675482", "R-DME-8948747", "R-MMU-9929356", "R-HSA-5205685", "R-CEL-9954716", "R-CEL-110312", "R-BTA-901032", "R-CFA-9755511", "R-CEL-2173795", "R-RNO-156827", "R-BTA-174084", "R-BTA-2559582", "R-DDI-8948751", "R-HSA-5675482", "R-CEL-2173796", "R-BTA-9708530", "R-CFA-6782135", "R-GGA-434131", "R-CFA-4641257", "R-DDI-174048", "R-SSC-1234176", "R-SSC-68949", "R-MMU-9708530", "R-DDI-450302", "R-RNO-450302", "R-BTA-8948747", "R-DME-209447", "R-BTA-9646399", "R-CFA-1253288", "R-CFA-174184", "R-DME-2871837", "R-DDI-6782135", "R-DDI-975956", "R-MMU-8863795", "R-DME-937042", "R-CFA-174154", "R-CFA-5668541", "R-DDI-8948747", "R-MMU-110312", "R-CFA-5675482", "R-BTA-2173796", "R-HSA-2565942", "R-CFA-5689880", "R-BTA-5654733", "R-MMU-937039", "R-RNO-5610780", "R-SSC-9706369", "R-DME-5689603", "R-MMU-901032", "R-MMU-5658442", "R-CFA-195253", "R-MMU-168638", "R-HSA-174084", "R-SSC-6804760", "R-SSC-8856825", "R-MMU-4608870", "R-BTA-5610780", "R-DME-72695", "R-MMU-72702", "R-RNO-8856825", "R-SSC-2559582", "R-DME-5675482", "R-HSA-72689", "R-CEL-5696397", "R-SSC-5357956", "R-BTA-9954714", "R-HSA-9706377", "R-RNO-2559580", "R-DDI-349425", "R-HSA-69017", "R-BTA-9020702", "R-BTA-975956", "R-RNO-9766229", "R-HSA-9014325", "R-SSC-5632684", "R-SSC-182971", "R-DDI-174154", "R-DDI-450321", "R-HSA-9633012", "R-RNO-2871837", "R-MMU-2173795", "R-RNO-917729", "R-RNO-68949", "R-HSA-9637628", "R-MMU-917729", "R-MMU-8941858", "R-SSC-5685942", "R-DME-2173788", "R-MMU-174154", "R-MMU-9861718", "R-SSC-209543", "R-MMU-937072", "R-RNO-382556", "R-RNO-5687128", "R-HSA-5693565", "R-BTA-975144", "R-SSC-5357905", "R-MMU-5689896", "R-MMU-69481", "R-DME-5689896", "R-RNO-9033241", "R-MMU-5689877", "R-HSA-2979096", "R-RNO-5696397", "R-HSA-5684264", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-HSA-5610783", "R-HSA-2122947", "R-SSC-450321", "R-BTA-68867", "R-MMU-6791226", "R-CFA-2122948", "R-MMU-174113", "R-SSC-983168", "R-RNO-174048", "R-SSC-382556", "R-SSC-450302", "R-CEL-5654727", "R-DME-1253288", "R-CFA-1295596", "R-RNO-5689880", "R-RNO-5696394", "R-DME-9648002", "R-RNO-72649", "R-RNO-179409", "R-MMU-9646399", "R-HSA-5696395", "R-BTA-8866654", "R-HSA-174048", "R-DME-72702", "R-MMU-5687128", "R-BTA-532668", "R-DME-5358346", "R-HSA-9664873", "R-SSC-75815", "R-HSA-5685942", "R-BTA-5357956", "R-MMU-8852276", "R-RNO-901032", "R-MMU-68949", "R-RNO-8866652", "R-BTA-6781823", "R-HSA-5357905", "R-MMU-9013507", "R-BTA-5656169", "R-HSA-9615710", "R-BTA-174184", "R-DME-917937", "R-MMU-9824878", "R-BTA-8939236", "R-HSA-5610780", "R-DME-8866654", "R-SSC-6783310", "R-SSC-6782135", "R-DDI-532668", "R-DME-9646399", "R-CFA-182971", "R-MMU-5607761", "R-CEL-5689880", "R-DME-445989", "R-HSA-917729", "R-HSA-975957", "R-SSC-9758274", "R-RNO-5696400", "R-MMU-6807004", "R-DME-2173796", "R-RNO-3769402", "R-SSC-5696400", "R-SSC-9770562", "R-RNO-195253", "R-DME-5654733", "R-MMU-2559585", "R-GGA-433822", "R-DDI-5358346", "R-DME-209560", "R-CEL-1253288", "R-BTA-179409", "R-DME-8951664", "R-HSA-9766229", "R-CEL-187577", "R-CFA-349425", "R-MMU-1295596", "R-CFA-5654727", "R-CFA-5675221", "R-CFA-69541", "R-BTA-9929491", "R-HSA-8866652", "R-RNO-9954716", "R-DDI-2559582", "R-MMU-5654732", "R-MMU-5684264", "R-MMU-9954714", "R-GGA-1227888", "R-DDI-5658442", "R-HSA-975144", "R-DME-110320", "R-SSC-5656169", "R-RNO-209560", "R-HSA-5654732", "R-DME-179409", "R-BTA-1253288", "R-CEL-9929491", "R-MMU-9705462", "R-RNO-9931295", "R-MMU-2871837", "R-RNO-1358803", "R-HSA-6791226", "R-MMU-6782210", "R-CFA-2559580", "R-RNO-983168", "R-CFA-912631", "R-DDI-72702", "R-HSA-445989", "R-MMU-69231", "R-DME-6804757", "R-DME-1169091", "R-CEL-8849469", "R-HSA-3769402", "R-BTA-110312", "R-CFA-5607761", "R-CEL-5205685", "R-HSA-174184", "R-MMU-174048", "R-CFA-5687128", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-RNO-6804756", "R-HSA-175474", "R-BTA-5696395", "R-RNO-9648002", "R-BTA-168638", "R-DME-68949", "R-DME-8856825", "R-CFA-9766229", "R-CEL-9954709", "R-HSA-8948747", "R-SSC-5696395", "R-BTA-5689877", "R-MMU-5685942", "R-SSC-9929491", "R-BTA-909733", "R-RNO-5658442", "R-BTA-5685942", "R-RNO-5610785", "R-RNO-5675482", "R-SSC-936440", "R-DME-5654726", "R-CFA-2559582", "R-CFA-5654726", "R-CFA-2173796", "R-DME-68867", "R-HSA-975163", "R-CFA-2173788", "R-CFA-187577", "R-RNO-9758274", "R-SSC-5689603", "R-RNO-5668541", "R-HSA-2559580", "R-HSA-912631", "R-HSA-75815", "R-HSA-9918487", "R-CFA-69601", "R-RNO-110314", "R-MMU-8948751", "R-RNO-8866654", "R-DME-8948751", "R-RNO-4641263", "R-BTA-201681", "R-DME-72706", "R-MMU-937042", "R-RNO-912631", "R-CEL-110314", "R-CFA-2559585", "R-CEL-3134975", "R-BTA-1169091", "R-CFA-6807004", "R-DME-9664873", "R-DME-5676590", "R-CFA-9645460", "R-HSA-2691232", "R-HSA-9013507", "R-SSC-975144", "R-GGA-433871", "R-DDI-174084", "R-HSA-5607761", "R-RNO-5656121", "R-MMU-9932298", "R-RNO-5696395", "R-RNO-975163", "R-SSC-8849469", "R-DME-450302", "R-RNO-209543", "R-HSA-8866654", "R-CFA-174113", "R-MMU-4641258", "R-HSA-909733", "R-SSC-975957", "R-CEL-6782135", "R-RNO-936440", "R-RNO-9954709", "R-BTA-4641257", "R-BTA-6782210", "R-CEL-8948751", "R-SSC-5656121", "R-BTA-205043", "R-MMU-9766229", "R-RNO-69481", "R-DDI-187577", "R-HSA-174154", "R-HSA-9833109", "R-RNO-1234176", "R-RNO-9932298", "R-CFA-2467813", "R-MMU-9645460", "R-CFA-5689901", "R-HSA-156827", "R-RNO-450321", "R-CFA-209560", "R-RNO-5654727", "R-CFA-68949", "R-DME-450321", "R-BTA-9010553", "R-HSA-2173795", "R-SSC-5689901", "R-HSA-9762114", "R-SSC-6804756", "R-MMU-975956", "R-CEL-8856828", "R-HSA-9770562", "R-HSA-4641263", "R-CFA-6782210", "R-DME-8939236", "R-RNO-174113", "R-HSA-1358803", "R-DDI-5675221", "R-RNO-9824878", "R-BTA-9645460", "R-CFA-69017", "R-DME-9954714", "R-DDI-9664873", "R-CEL-2565942", "R-DDI-1799339", "R-CFA-937072", "R-BTA-110320", "R-HSA-2173788", "R-DME-975957", "R-BTA-5357905", "R-DME-5689880", "R-MMU-1253288", "R-RNO-201681", "R-RNO-110312", "R-SSC-2173788", "R-CFA-8951664", "R-HSA-5689896", "R-HSA-8856828", "R-HSA-9828211", "R-BTA-202424", "R-MMU-110320", "R-MMU-5689901", "R-MMU-2122948", "R-SSC-909733", "R-DME-912631", "R-MMU-5205685", "R-MMU-2565942", "R-HSA-936964", "R-MMU-5696395", "R-DME-8939902", "R-CEL-382556", "R-SSC-937042", "R-CEL-5654732", "R-CFA-5656121", "R-HSA-6804757", "R-DME-4608870", "R-SSC-445989", "R-RNO-6782210", "R-SSC-72706", "R-RNO-5205685", "R-HSA-209560", "R-CFA-9648002", "R-SSC-1169091", "R-CFA-9932298", "R-DDI-6781823", "R-CFA-382556", "R-HSA-4641258", "R-CEL-6781823", "R-RNO-6791226", "R-BTA-4641258", "R-CFA-901032", "R-HSA-4608870", "R-RNO-3134975", "R-BTA-937039", "R-MMU-1799339", "R-MMU-5610780", "R-SSC-209560", "R-CEL-8863795", "R-RNO-1295596", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-CFA-9758274", "R-SSC-156827", "R-HSA-5362768", "R-DDI-9954709", "R-RNO-8852276", "R-BTA-6807004", "R-BTA-174178", "R-SSC-532668", "R-BTA-3769402", "R-CFA-8948747", "R-CFA-937039", "R-HSA-2173791", "R-SSC-975956", "R-SSC-8854050", "R-GGA-434001", "R-CFA-9931295", "R-RNO-110320", "R-BTA-8854050", "R-HSA-9683683", "R-SSC-8866654", "R-BTA-5607764", "R-DDI-450408", "R-HSA-69541", "R-SSC-9664873", "R-SSC-1253288", "R-CFA-1169091", "R-CEL-5632684", "R-HSA-5689880", "R-CFA-8863795", "R-CFA-2173795", "R-SSC-6782210", "R-DME-5654732", "R-BTA-450321", "R-CFA-9861718", "R-CFA-937041", "R-DME-1295596", "R-CFA-5689603", "R-HSA-1234176", "R-DME-2559582", "R-MMU-68867", "R-RNO-5654732", "R-DME-174048", "R-HSA-182971", "R-BTA-182971", "R-BTA-6782135", "R-DME-209461", "R-BTA-2173788", "R-HSA-6804760", "R-CFA-5655862", "R-CFA-6781823", "R-SSC-5654733", "R-CEL-5696395", "R-BTA-917937", "R-SSC-110314", "R-HSA-5696394", "R-DME-69601", "R-HSA-2644606", "R-CFA-5610785", "R-CEL-8856825", "R-MMU-5675221", "R-DME-69017", "R-DME-983168", "R-RNO-5676590", "R-HSA-6781827", "R-HSA-2467813", "R-HSA-168928", "R-HSA-937042", "R-BTA-195253", "R-DDI-6791226", "R-RNO-69601", "R-CFA-205043", "R-SSC-349425", "R-HSA-9861718", "R-MMU-9664873", "R-MMU-917937", "R-SSC-9931295", "R-CEL-75815", "R-SSC-917937", "R-SSC-195253", "R-CFA-936964", "R-MMU-9762114", "R-BTA-5696400", "R-MMU-205043", "R-CFA-5357956", "R-MMU-195253", "R-MMU-72695", "R-BTA-8856828", "R-MMU-382556", "R-BTA-9705462", "R-DME-209360", "R-DME-5357905", "R-CFA-975163", "R-DME-72689", "R-RNO-75815", "R-MMU-1169091", "R-RNO-72702", "R-DME-8854050", "R-SSC-202424", "R-RNO-9770562", "R-SSC-3769402", "R-CFA-445989", "R-HSA-5696400", "R-SSC-917729", "R-CEL-9020702", "R-RNO-9954714", "R-DDI-8854050", "R-CFA-9931269", "R-BTA-69231", "R-MMU-5607764", "R-DME-69231", "R-BTA-5668541", "R-DME-5656121", "R-HSA-5676590", "R-DME-9954716", "R-BTA-72689", "R-CFA-174048", "R-DDI-9020702", "R-SSC-5684264", "R-HSA-3322077", "R-HSA-174490", "R-MMU-975163", "R-RNO-5607761", "R-HSA-1799339", "R-CFA-6783310", "R-CEL-4641258", "R-BTA-937042", "R-DME-5689877", "R-CFA-9020702", "R-HSA-110312", "R-SSC-69601", "R-DME-2173791", "R-CFA-8854050", "R-DME-3769402", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-RNO-532668", "R-HSA-1253288", "R-CFA-975144", "R-HSA-3134975", "R-HSA-9613829", "R-DDI-5689877", "R-RNO-2122948", "R-HSA-110314", "R-HSA-5689901", "R-SSC-8866652", "R-HSA-187577", "R-HSA-901032", "R-CFA-75815", "R-DME-382556", "R-HSA-209543", "R-DME-5610780", "R-DDI-9770562", "R-SSC-8951664", "R-DME-195253", "R-MMU-69601", "R-CFA-5696397", "R-SSC-174084", "R-RNO-2672351", "R-DDI-975163", "R-BTA-5654732", "R-DME-110312", "R-HSA-1236382", "R-DME-5607761", "R-MMU-8854050", "R-CFA-110312", "R-HSA-5656169", "R-HSA-937072", "R-HSA-5607764", "R-CFA-5696395", "R-MMU-1358803", "R-RNO-8948747", "R-MMU-3769402", "R-SSC-6807004", "R-DME-9033241", "R-RNO-6782135", "R-BTA-2173791", "R-SSC-9954709", "R-SSC-8852276", "R-DME-538864", "R-CEL-68949", "R-HSA-5687128", "R-BTA-450302", "R-RNO-909733", "R-RNO-5357956", "R-SSC-4608870", "R-DDI-72706", "R-HSA-110320", "R-BTA-975163"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-8951664:r:Neddylation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-69231:r:Cyclin D associated events in G1", "R-CEL-5689877:r:Josephin domain DUBs", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SSC-110320:r:Translesion Synthesis by POLH", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-182971:r:EGFR downregulation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-SSC-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-DME-4641257:r:Degradation of AXIN", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-CFA-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-BTA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-SSC-8948747:r:Regulation of PTEN localization", "R-CFA-917937:r:Iron uptake and transport", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-4641257:r:Degradation of AXIN", "R-MMU-8951664:r:Neddylation", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-5689603:r:UCH proteinases", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CFA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-9648002:r:RAS processing", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-SSC-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-5654727:r:Negative regulation of FGFR2 signaling", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-CEL-5689901:r:Metalloprotease DUBs", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-SSC-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SSC-9646399:r:Aggrephagy", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-9648002:r:RAS processing", "R-SSC-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-CEL-9646399:r:Aggrephagy", "R-CFA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-GGA-353303:r:Nucleotide Excision Repair", "R-CFA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CFA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-5689877:r:Josephin domain DUBs", "R-SSC-4641258:r:Degradation of DVL", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-CEL-4641257:r:Degradation of AXIN", "R-CFA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-CFA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-CFA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-69231:r:Cyclin D associated events in G1", "R-DDI-9033241:r:Peroxisomal protein import", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-CEL-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8951664:r:Neddylation", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1236974:r:ER-Phagosome pathway", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9648002:r:RAS processing", "R-SSC-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-BTA-68949:r:Orc1 removal from chromatin", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2672351:r:Stimuli-sensing channels", "R-CFA-5632684:r:Hedgehog 'on' state", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-69541:r:Stabilization of p53", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SSC-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-SSC-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-912631:r:Regulation of signaling by CBL", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9706369:r:Negative regulation of FLT3", "R-DME-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-5696400:r:Dual Incision in GG-NER", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-9646399:r:Aggrephagy", "R-CFA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-182971:r:EGFR downregulation", "R-SSC-9033241:r:Peroxisomal protein import", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SSC-68867:r:Assembly of the pre-replicative complex", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-SSC-69481:r:G2/M Checkpoints", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-CFA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CFA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-9861718:r:Regulation of pyruvate metabolism", "R-SSC-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-CFA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-SSC-5689880:r:Ub-specific processing proteases", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CFA-202424:r:Downstream TCR signaling", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-CEL-6807004:r:Negative regulation of MET activity", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-8866427:r:VLDLR internalisation and degradation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-SSC-8948751:r:Regulation of PTEN stability and activity", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-5689901:r:Metalloprotease DUBs", "R-DME-5655862:r:Translesion synthesis by POLK", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-69481:r:G2/M Checkpoints", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-CFA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-9770562:r:mRNA Polyadenylation", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SSC-5358346:r:Hedgehog ligand biogenesis", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9706369:r:Negative regulation of FLT3", "R-CFA-68867:r:Assembly of the pre-replicative complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CFA-69231:r:Cyclin D associated events in G1", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-CEL-2672351:r:Stimuli-sensing channels", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-9020702:r:Interleukin-1 signaling", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-8948747:r:Regulation of PTEN localization", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-CFA-4641258:r:Degradation of DVL", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5689877:r:Josephin domain DUBs", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-9706369:r:Negative regulation of FLT3", "R-DDI-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-SSC-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-CFA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-4641257:r:Degradation of AXIN", "R-CFA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 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Listeria monocytogenes into host cells", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-SSC-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-182971:r:EGFR downregulation", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-937039:r:IRAK1 recruits IKK complex", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-CFA-69481:r:G2/M Checkpoints", "R-CFA-2672351:r:Stimuli-sensing channels", "R-SSC-69231:r:Cyclin D associated events in G1", "R-CFA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-179409:r:APC-Cdc20 mediated 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activation mediated by activated human TAK1", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-CEL-9648002:r:RAS processing", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-SSC-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CFA-4641263:r:Regulation of FZD by ubiquitination", "R-DME-182971:r:EGFR downregulation", "R-CFA-909733:r:Interferon alpha/beta signaling", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-SSC-5689896:r:Ovarian tumor domain proteases", "R-SSC-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SSC-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-4641257:r:Degradation of AXIN", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-5689603:r:UCH proteinases", "R-SSC-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689877:r:Josephin domain DUBs", "R-SSC-9020702:r:Interleukin-1 signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-9664873:r:Pexophagy", "R-CFA-9033241:r:Peroxisomal protein import", "R-CFA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-9708530:r:Regulation of BACH1 activity", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-CFA-5696400:r:Dual Incision in GG-NER", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-CFA-5689877:r:Josephin domain DUBs", "R-CFA-9706369:r:Negative regulation of FLT3", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-SSC-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-2122948:r:Activated NOTCH1 Transmits Signal to the 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complex extracts and degrades nascent peptide", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9694493:r:Maturation of protein E", "R-RNO-917937:r:Iron uptake and transport", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-912631:r:Regulation of signaling by CBL", "R-DME-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-CFA-9646399:r:Aggrephagy", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-DDI-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-CFA-110320:r:Translesion Synthesis by POLH", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-573298:r:NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-CFA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-72689:r:Formation 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TP53 Activity through Methylation", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CFA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-CFA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex 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Calnexin/Calreticulin cycle", "R-DME-432524:r:Degradation of PER", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-CFA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SSC-9932298:r:Degradation of CRY and PER proteins", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-5689901:r:Metalloprotease DUBs", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-SSC-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-SSC-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CFA-6804760:r:Regulation of TP53 Activity through Methylation", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-5689880:r:Ub-specific processing proteases", "R-CFA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SSC-8941858:r:Regulation of 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POLI", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-CFA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CFA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-5655862:r:Translesion synthesis by POLK", "R-SSC-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-9033241:r:Peroxisomal protein import", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-CFA-9664873:r:Pexophagy", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-DME-8948747:r:Regulation of PTEN localization", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-110312:r:Translesion synthesis by REV1", "R-BTA-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-CFA-6782135:r:Dual incision in TC-NER", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-CFA-4641257:r:Degradation of AXIN", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-SSC-68949:r:Orc1 removal from chromatin", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-8948747:r:Regulation of PTEN localization", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-BTA-9646399:r:Aggrephagy", "R-CFA-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CFA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-8948747:r:Regulation of PTEN localization", "R-MMU-110312:r:Translesion synthesis by REV1", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CFA-5689880:r:Ub-specific processing proteases", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-SSC-9706369:r:Negative regulation of FLT3", "R-DME-5689603:r:UCH proteinases", "R-MMU-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-CFA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SSC-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-SSC-5632684:r:Hedgehog 'on' state", "R-SSC-182971:r:EGFR downregulation", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-5685942:r:HDR through Homologous Recombination (HRR)", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-SSC-209543:r:p75NTR recruits signalling complexes", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-69481:r:G2/M Checkpoints", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-5689877:r:Josephin domain DUBs", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-SSC-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-382556:r:ABC-family proteins mediated transport", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-1295596:r:Spry regulation of FGF signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-9648002:r:RAS processing", "R-RNO-72649:r:Translation initiation complex formation", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9646399:r:Aggrephagy", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9664873:r:Pexophagy", "R-SSC-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9615710:r:Late endosomal microautophagy", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-917937:r:Iron uptake and transport", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SSC-6783310:r:Fanconi Anemia Pathway", "R-SSC-6782135:r:Dual incision in TC-NER", "R-DDI-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-9646399:r:Aggrephagy", "R-CFA-182971:r:EGFR downregulation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-MMU-6807004:r:Negative regulation of MET activity", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-5696400:r:Dual Incision in GG-NER", "R-SSC-9770562:r:mRNA Polyadenylation", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-DDI-5358346:r:Hedgehog ligand biogenesis", "R-DME-209560:r:NF-kB is activated and signals survival", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CFA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-CFA-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-5675221:r:Negative regulation of MAPK pathway", "R-CFA-69541:r:Stabilization of p53", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-1227888:r:Negative Regulation of MDA5 signaling", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DME-110320:r:Translesion Synthesis by POLH", "R-SSC-5656169:r:Termination of translesion DNA synthesis", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-1253288:r:Downregulation of ERBB4 signaling", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-912631:r:Regulation of signaling by CBL", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-BTA-110312:r:Translesion synthesis by REV1", "R-CFA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-CFA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-9648002:r:RAS processing", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CFA-9766229:r:Degradation of CDH1", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-8948747:r:Regulation of PTEN localization", "R-SSC-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5689877:r:Josephin domain DUBs", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SSC-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-SSC-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-CFA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CFA-5654726:r:Negative regulation of FGFR1 signaling", "R-CFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-CFA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CFA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-SSC-5689603:r:UCH proteinases", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-912631:r:Regulation of signaling by CBL", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-CFA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-2559585:r:Oncogene Induced Senescence", "R-CEL-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-CFA-6807004:r:Negative regulation of MET activity", "R-DME-9664873:r:Pexophagy", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-CFA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-433871:r:TRAF6 mediated induction of proinflammatory cytokines", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5607761:r:Dectin-1 mediated 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{"description": "Lysosome-associated membrane glycoprotein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Lysosome-assoc_membr_glycop", "pathway_ids": ["R-HSA-6798695", "R-HSA-114608", "R-CEL-6798695", "R-HSA-9613829", "R-MMU-6798695", "R-CEL-114608", "R-BTA-6798695", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-114608:r:Platelet degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR002003": {"description": "Gas vesicle protein GvpC", "go_ids": ["GO:0031411", "GO:0031412"], "go_terms": ["GO:0031411:gas vesicle:C", "GO:0031412:gas vesicle organization:P"], "name": "Gas-vesicle_GvpC", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR002004": {"description": "Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "PABP_HYD_C", "pathway_ids": ["R-MMU-450408", "R-DDI-975956", "R-DME-156827", "R-BTA-975957", "R-DME-429947", "R-HSA-9010553", "R-HSA-9918487", "R-DME-72649", "R-SPO-975957", "R-HSA-156827", "R-MMU-72649", "R-HSA-975956", "R-HSA-9820865", "R-DME-450408", "R-SCE-975957", "R-MMU-429947", "R-BTA-429947", "R-HSA-450408", "R-RNO-450408", "R-MMU-975956", "R-RNO-975957", "R-DRE-156827", "R-SCE-156827", "R-DRE-975956", "R-SPO-975956", "R-DME-975956", "R-BTA-156827", "R-RNO-156827", "R-SPO-72649", "R-BTA-450408", "R-SCE-975956", "R-HSA-429947", "R-MMU-975957", "R-DRE-975957", "R-DRE-450408", "R-HSA-72649", "R-MMU-156827", "R-RNO-429947", "R-RNO-72649", "R-DRE-72649", "R-HSA-975957", "R-SCE-72649", "R-RNO-975956", "R-BTA-975956", "R-HSA-9820841", 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Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72649:r:Translation initiation complex formation", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-429947:r:Deadenylation of mRNA", "R-RNO-72649:r:Translation 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"R-SPO-429947:r:Deadenylation of mRNA", "R-SCE-429947:r:Deadenylation of mRNA"], "type": "Domain"}, "IPR002006": {"description": "Hepatitis core antigen", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Hepatitis_core", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002009": {"description": "Bromovirus coat protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Bromo_CP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002010": {"description": "Type III secretion system inner membrane R protein", "go_ids": ["GO:0006605", "GO:0016020"], "go_terms": ["GO:0006605:protein targeting:P", "GO:0016020:membrane:C"], "name": "T3SS_IM_R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002012": {"description": "Gonadotropin-releasing hormone", "go_ids": ["GO:0005179", "GO:0005576", "GO:0007275"], "go_terms": ["GO:0005179:hormone 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"R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-HSA-4641258", "R-RNO-8939236", "R-SPO-5689603", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-BTA-4641258", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-RNO-2467813", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-DME-8941858", "R-SPO-6798695", "R-MMU-5610780", "R-DME-9954709", "R-BTA-382556", "R-CEL-8939902", "R-MMU-9755511", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-HSA-5362768", "R-DME-5689603", "R-DDI-9954709", "R-DME-216167", "R-MMU-5658442", "R-RNO-8852276", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-RNO-9907900", "R-BTA-8948751", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-RNO-5607764", "R-RNO-8941858", "R-RNO-1169091", "R-HSA-69017", "R-BTA-9020702", "R-RNO-9766229", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-HSA-202424", "R-CEL-4641257", "R-DDI-174154", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-BTA-1234176", "R-MMU-174154", "R-MMU-69017", "R-CEL-195253", "R-MMU-9020702", "R-DME-5658442", "R-RNO-5687128", "R-RNO-382556", "R-MMU-69481", "R-BTA-350562", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541"], "pathways": ["R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-8951664:r:Neddylation", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-9907900:r:Proteasome assembly", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-4641257:r:Degradation of AXIN", "R-DME-9907900:r:Proteasome assembly", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8951664:r:Neddylation", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-5632684:r:Hedgehog 'on' state", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5689603:r:UCH proteinases", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-68949:r:Orc1 removal from chromatin", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early 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"R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5632684:r:Hedgehog 'on' state", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-202424:r:Downstream TCR signaling", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9907900:r:Proteasome assembly", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction 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nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CEL-5689603:r:UCH proteinases", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-5689603:r:UCH proteinases", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-4641258:r:Degradation of DVL", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades 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other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-9907900:r:Proteasome assembly", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5689603:r:UCH proteinases", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-202424:r:Downstream TCR signaling", "R-CEL-4641257:r:Degradation of AXIN", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway"], "type": "Repeat"}, "IPR002016": {"description": "Haem peroxidase", "go_ids": ["GO:0004601", "GO:0006979", "GO:0020037"], "go_terms": ["GO:0004601:peroxidase activity:F", "GO:0006979:response to oxidative stress:P", "GO:0020037:heme binding:F"], "name": "Haem_peroxidase", "pathway_ids": ["PWY-5506", "R-HSA-1222387"], "pathways": ["PWY-5506:t:methanol oxidation to formaldehyde IV", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Domain"}, "IPR002017": {"description": "Spectrin repeat", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Spectrin_repeat", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9013405", "R-RNO-445095", "R-HSA-9013418", "R-RNO-9013409", "R-GGA-446388", "R-BTA-5673001", "R-MMU-9013408", "R-RNO-446388", "R-RNO-5687128", "R-MMU-9013409", "R-DDI-114608", "R-HSA-442982", "R-MMU-9013420", "R-HSA-9662360", "R-BTA-438066", "R-RNO-375165", "R-HSA-446107", "R-RNO-416476", "R-RNO-193648", "R-MMU-5673001", "R-DDI-6798695", "R-MMU-9035034", "R-DME-114608", "R-HSA-3000171", "R-HSA-416482", "R-CEL-6807878", "R-RNO-9013148", "R-HSA-9696264", "R-MMU-9013423", "R-HSA-2022090", "R-MMU-193648", "R-HSA-9013026", "R-DRE-8980692", "R-MMU-9696264", 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"R-HSA-373753", "R-DME-445095", "R-MMU-438066", "R-MMU-390522", "R-GGA-9013418", "R-BTA-390522", "R-RNO-418885", "R-HSA-5673001", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9913351", "R-MMU-445095", "R-DME-446388", "R-HSA-9620244", "R-MMU-6798695", "R-DRE-416482", "R-MMU-375165", "R-MMU-114608", "R-DRE-9013423", "R-CEL-375165", "R-HSA-2132295", "R-HSA-9619665", "R-MMU-9013148", "R-HSA-416476", "R-HSA-418885", "R-MMU-6807878", "R-DME-9013424", "R-HSA-375165", "R-HSA-1221632", "R-RNO-114608", "R-BTA-114608", "R-HSA-9035034", "R-DRE-9013149", "R-RNO-9013106", "R-HSA-9617324", "R-HSA-193648", "R-HSA-9013420", "R-DRE-9013408", "R-RNO-390522", "R-CEL-9913351", "R-RNO-6807878", "R-HSA-9662361", "R-HSA-6807878", "R-DME-9013418", "R-RNO-9913351", "R-HSA-9703465", "R-DRE-9013148", "R-HSA-5687128", "R-HSA-438066", "R-DDI-6807878", "R-MMU-9013026", "R-MMU-416482", "R-MMU-3928662", "R-HSA-390522", "R-RNO-264870", "R-DRE-416476", "R-MMU-9696270", "R-HSA-9696273", "R-MMU-418885"], 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"R-HSA-446107:r:Type I hemidesmosome assembly", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-114608:r:Platelet degranulation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-114608:r:Platelet degranulation", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9013424:r:RHOV GTPase cycle", "R-BTA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-GGA-114608:r:Platelet degranulation", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-9035034:r:RHOF GTPase cycle", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-446388:r:Regulation of cytoskeletal 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mediated attractive signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-9620244:r:Long-term potentiation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-MMU-114608:r:Platelet degranulation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1221632:r:Meiotic synapsis", "R-RNO-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DRE-9013408:r:RHOG GTPase cycle", "R-RNO-390522:r:Striated Muscle Contraction", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-DRE-416476:r:G alpha (q) signalling events", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Repeat"}, "IPR002018": {"description": "Carboxylesterase, type B", "go_ids": [], "go_terms": [], "name": "CarbesteraseB", "pathway_ids": ["R-HSA-211945", "R-DDI-9749641", "R-CEL-211945", "R-DME-2022377", "R-HSA-9925561", "R-CEL-5578768", "R-HSA-6794361", "R-HSA-8964038", "R-DME-9749641", "R-HSA-5578768", "R-CEL-1483191", "R-MMU-422085", "R-HSA-192456", "R-MMU-8964038", "R-DDI-112311", "R-MMU-9749641", "R-DDI-8964038", "R-DME-8964038", "R-BTA-9749641", "R-CEL-112311", "R-DDI-211945", "R-MMU-2022377", "R-MMU-5578768", "R-CEL-6794361", "R-DDI-1483191", "R-DDI-5578768", "R-MMU-6794361", "R-RNO-5578768", "R-CEL-192456", "R-RNO-2022377", "R-DME-5578768", "R-MMU-192456", "R-CEL-9749641", "R-HSA-2022377", "R-HSA-422085", "R-RNO-192456", "R-HSA-1483191", "R-RNO-211945", "R-DDI-2022377", "R-BTA-422085", "R-CEL-8964038", "R-HSA-9749641", "R-DME-112311", "R-RNO-9749641", "R-DME-211945", "R-CEL-2022377", "R-DME-1483191", "R-RNO-6794361", "R-HSA-112311", "R-MMU-211945"], "pathways": ["R-HSA-211945:r:Phase I - Functionalization of compounds", "R-DDI-9749641:r:Aspirin ADME", "R-CEL-211945:r:Phase I - Functionalization of compounds", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-CEL-5578768:r:Physiological factors", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-8964038:r:LDL clearance", "R-DME-9749641:r:Aspirin ADME", "R-HSA-5578768:r:Physiological factors", "R-CEL-1483191:r:Synthesis of PC", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-192456:r:Digestion of dietary lipid", "R-MMU-8964038:r:LDL clearance", "R-DDI-112311:r:Neurotransmitter clearance", "R-MMU-9749641:r:Aspirin ADME", "R-DDI-8964038:r:LDL clearance", "R-DME-8964038:r:LDL clearance", "R-BTA-9749641:r:Aspirin ADME", "R-CEL-112311:r:Neurotransmitter clearance", "R-DDI-211945:r:Phase I - Functionalization of compounds", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-5578768:r:Physiological factors", "R-CEL-6794361:r:Neurexins and neuroligins", "R-DDI-1483191:r:Synthesis of PC", "R-DDI-5578768:r:Physiological factors", "R-MMU-6794361:r:Neurexins and neuroligins", "R-RNO-5578768:r:Physiological factors", "R-CEL-192456:r:Digestion of dietary lipid", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-5578768:r:Physiological factors", "R-MMU-192456:r:Digestion of dietary lipid", "R-CEL-9749641:r:Aspirin ADME", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-192456:r:Digestion of dietary lipid", "R-HSA-1483191:r:Synthesis of PC", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-DDI-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-CEL-8964038:r:LDL clearance", "R-HSA-9749641:r:Aspirin ADME", "R-DME-112311:r:Neurotransmitter clearance", "R-RNO-9749641:r:Aspirin ADME", "R-DME-211945:r:Phase I - Functionalization of compounds", "R-CEL-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-1483191:r:Synthesis of PC", "R-RNO-6794361:r:Neurexins and neuroligins", "R-HSA-112311:r:Neurotransmitter clearance", "R-MMU-211945:r:Phase I - Functionalization of compounds"], "type": "Domain"}, "IPR002019": {"description": "Urease, beta subunit-like", "go_ids": ["GO:0043419", "GO:0035550"], "go_terms": ["GO:0043419:urea catabolic process:P", "GO:0035550:urease complex:C"], "name": "Urease_beta-like", "pathway_ids": ["PWY-5704"], "pathways": ["PWY-5704:t:urea degradation II"], "type": "Family"}, "IPR002020": {"description": "Citrate synthase", "go_ids": ["GO:0046912"], "go_terms": ["GO:0046912:acyltransferase activity, acyl groups converted into alkyl on transfer:F"], "name": "Citrate_synthase", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-SPO-6798695", "R-MMU-9837999", "R-DDI-75105", "R-CEL-6798695", "R-BTA-6798695", "R-DRE-9854311", "R-RNO-75105", "R-GGA-372987", "R-SPO-71403", "R-CEL-71403", "R-HSA-1268020", "R-MMU-71403", "R-BTA-9837999", "R-HSA-9837999", "R-DDI-71403", "R-RNO-71403", "R-HSA-71403", "R-XTR-9837999", "R-HSA-163765", "R-DDI-6798695", "R-DDI-9837999", "R-HSA-9854311", "R-CEL-9837999", "R-BTA-9854311", "R-BTA-71403", "R-SPO-75105", "R-DME-9837999", "R-RNO-9837999", "R-SSC-9854311", "R-MMU-75105", "R-DRE-71403", "R-DRE-9837999", "R-BTA-75105", "R-SSC-71403", "R-SPO-9837999", "R-SCE-71403", "R-SCE-9837999", "R-HSA-75105", "R-SSC-9837999", "R-MMU-6798695", "R-DME-71403", "R-XTR-71403", "R-CEL-75105"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9837999:r:Mitochondrial protein degradation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Family"}, "IPR002021": {"description": "Paramyxovirus nucleocapsid protein", "go_ids": ["GO:0005198", "GO:0019013"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019013:viral nucleocapsid:C"], "name": "Paramyx_ncap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002022": {"description": "Pectate lyase", "go_ids": [], "go_terms": [], "name": "Pec_lyase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002023": {"description": "NADH-quinone oxidoreductase subunit E-like", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "NuoE-like", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198", "R-MMU-611105", "R-BTA-6799198", "R-DDI-6799198", "R-BTA-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR002024": {"description": "Bacterioferritin", "go_ids": ["GO:0006826", 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["GO:0016020:membrane:C"], "name": "TatC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002035": {"description": "von Willebrand factor, type A", "go_ids": [], "go_terms": [], "name": "VWF_A", "pathway_ids": ["R-DME-2173789", "R-CEL-73779", "R-HSA-9013405", "R-HSA-73772", "R-HSA-8874081", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-HSA-6802952", "R-HSA-140837", "R-BTA-1483206", "R-DDI-73776", "R-DDI-6782210", "R-CEL-1566948", "R-RNO-73776", "R-HSA-9662360", "R-HSA-9846298", "R-HSA-8948216", "R-MMU-202733", "R-SSC-174577", "R-SPO-6796648", "R-CEL-73776", "R-HSA-6802955", "R-BTA-977606", "R-RNO-5576892", "R-HSA-3270619", "R-DDI-6798695", "R-BTA-75955", "R-DME-432524", "R-HSA-6802948", "R-CEL-5576892", "R-RNO-5696395", "R-HSA-8949275", "R-HSA-196807", "R-HSA-419037", "R-MMU-173736", "R-DME-216083", "R-CEL-674695", "R-CEL-112382", "R-DRE-381426", "R-CEL-6782135", "R-MMU-216083", "R-SPO-73779", "R-BTA-6782210", "R-DDI-113418", "R-MMU-72086", "R-CEL-2173789", "R-RNO-1483206", "R-SPO-73776", "R-MMU-354192", "R-DDI-5696395", "R-RNO-216083", "R-MMU-5674135", "R-RNO-5576893", "R-HSA-114608", "R-HSA-9907900", "R-DDI-73772", "R-MMU-2672351", "R-DDI-6796648", "R-HSA-9013148", "R-HSA-6782210", "R-DDI-76042", "R-HSA-1483206", "R-MMU-5696400", "R-SCE-73779", "R-MMU-2173789", "R-MMU-6796648", "R-HSA-3000170", "R-SSC-8957275", "R-MMU-1566977", "R-RNO-6796648", "R-DME-6798695", "R-RNO-75955", "R-SCE-6781823", "R-BTA-674695", "R-MMU-354194", "R-MMU-2022090", "R-RNO-422356", "R-MMU-77075", "R-HSA-75955", "R-BTA-166663", "R-SPO-6782210", "R-HSA-76042", "R-HSA-674695", "R-SCE-73772", "R-BTA-216083", "R-HSA-186797", "R-HSA-6798695", "R-RNO-6807505", "R-RNO-674695", "R-MMU-76009", "R-HSA-166016", "R-MMU-5694530", "R-RNO-112308", "R-BTA-6798695", "R-HSA-6796648", "R-HSA-5694530", "R-HSA-6781823", "R-SPO-5696395", "R-HSA-167246", "R-MMU-5696395", "R-HSA-5576893", "R-MMU-381426", "R-CEL-381426", "R-HSA-75953", "R-HSA-9672391", "R-HSA-77075", "R-SPO-72086", "R-RNO-6782210", "R-CEL-216083", "R-SPO-113418", "R-BTA-198933", "R-DDI-73779", "R-BTA-72086", "R-HSA-9683610", "R-DDI-6781823", "R-RNO-73762", "R-MMU-6807505", "R-HSA-164843", "R-SCE-76042", "R-CEL-6781823", "R-HSA-204005", "R-RNO-381426", "R-DME-6807505", "R-CEL-5576893", "R-SSC-173736", "R-MMU-198933", "R-HSA-167200", "R-RNO-112382", "R-MMU-9013406", "R-MMU-6798695", "R-DME-209406", "R-HSA-112308", "R-RNO-75953", "R-MMU-114608", "R-SCE-6782135", "R-DDI-6782135", "R-BTA-173736", "R-BTA-113418", "R-HSA-9845621", "R-CEL-422356", "R-RNO-114608", "R-HSA-416700", "R-HSA-977606", "R-MMU-174577", "R-HSA-113418", "R-HSA-174577", "R-HSA-1834949", "R-DME-216167", "R-DME-2129379", "R-BTA-73762", "R-RNO-72086", "R-HSA-2214320", "R-GGA-6807505", "R-HSA-216083", "R-HSA-445355", "R-SCE-72086", "R-HSA-73762", "R-CEL-77075", "R-SSC-977606", "R-DME-3000170", "R-SCE-77075", "R-HSA-8957275", "R-HSA-9013406", "R-SPO-6782135", "R-MMU-2129379", "R-RNO-6781823", "R-HSA-9013409", "R-HSA-3000178", "R-RNO-73779", "R-HSA-427413", "R-SPO-6781823", "R-MMU-445355", "R-HSA-9856532", "R-DME-445355", "R-HSA-167158", "R-MMU-75955", "R-MMU-3000170", "R-MMU-112382", "R-SPO-76042", "R-CEL-2129379", "R-HSA-73776", "R-BTA-77075", "R-MMU-5576893", "R-DDI-674695", "R-CEL-75953", "R-HSA-166663", "R-BTA-73863", "R-GGA-1650814", "R-SSC-381426", "R-BTA-75953", "R-BTA-6782135", "R-DME-209461", "R-DME-114608", "R-HSA-400042", "R-CEL-6782210", "R-HSA-447041", "R-HSA-167161", "R-HSA-2022090", "R-HSA-173736", "R-CEL-5696395", "R-HSA-167160", "R-HSA-5696395", "R-DDI-77075", "R-MMU-73772", "R-BTA-73772", "R-MMU-186797", "R-BTA-73776", "R-RNO-6798695", "R-HSA-9656223", "R-SCE-73776", "R-HSA-6781827", "R-HSA-9845620", "R-MMU-430116", "R-HSA-2672351", "R-CEL-9907900", "R-CEL-73772", "R-MMU-1483206", "R-BTA-6781823", "R-MMU-6781823", "R-DME-9907900", "R-MMU-8874081", "R-RNO-445355", "R-MMU-73776", "R-BTA-5696400", "R-GGA-381426", "R-HSA-167172", "R-HSA-1442490", "R-DRE-8957275", "R-BTA-73779", "R-RNO-113418", "R-DME-209360", "R-CEL-75955", "R-MMU-977606", "R-HSA-2129379", "R-DDI-9907900", "R-DME-446107", "R-DME-432626", "R-MMU-1236973", "R-BTA-174577", "R-HSA-5693571", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-MMU-1650814", "R-RNO-5696400", "R-HSA-5696400", "R-BTA-6807505", "R-HSA-202733", "R-HSA-112382", "R-HSA-73779", "R-HSA-422356", "R-MMU-204005", "R-HSA-5674135", "R-SCE-75953", "R-MMU-113418", "R-HSA-430116", "R-BTA-76042", "R-MMU-166663", "R-DDI-1483206", "R-RNO-73863", "R-MMU-8957275", "R-HSA-1650814", "R-MMU-2214320", "R-MMU-3000178", "R-HSA-9649948", "R-CEL-8957275", "R-GGA-8957275", "R-HSA-9926550", "R-CEL-112308", "R-HSA-5210891", "R-MMU-73779", "R-MMU-76042", "R-HSA-381426", "R-HSA-2173789", "R-SPO-75953", "R-HSA-9672393", "R-MMU-9907900", "R-RNO-76042", "R-MMU-166016", "R-MMU-140837", "R-HSA-9845619", "R-HSA-1236973", "R-CEL-113418", "R-DDI-72086", "R-HSA-6785807", "R-MMU-674695", "R-DME-354192", "R-HSA-9694631", "R-DDI-6807505", "R-HSA-75892", "R-DME-445144", "R-SCE-674695", "R-HSA-198933", "R-MMU-6782210", "R-HSA-372708", "R-CEL-6796648", "R-MMU-419037", "R-MMU-73762", "R-MMU-6782135", "R-HSA-3000157", "R-MMU-8948216", "R-MMU-422356", "R-MMU-5576892", "R-CEL-72086", "R-HSA-72086", "R-HSA-9845622", "R-HSA-5576892", "R-BTA-202733", "R-HSA-167162", "R-MMU-372708", "R-HSA-76009", "R-CEL-1474228", "R-BTA-114608", "R-DME-1236973", "R-HSA-6802946", "R-HSA-167152", "R-RNO-8957275", "R-BTA-5696395", "R-SCE-6782210", "R-BTA-6796648", "R-MMU-112308", "R-MMU-1442490", "R-HSA-354192", "R-SCE-6796648", "R-SPO-77075", "R-RNO-73772", "R-RNO-6782135", "R-SCE-113418", "R-HSA-1566977", "R-MMU-73863", "R-HSA-354194", "R-HSA-6782135", "R-DME-538864", "R-SCE-9907900", "R-SPO-5696400", "R-DME-432395", "R-DDI-75953", "R-CEL-76042"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-1483206:r:Glycerophospholipid biosynthesis", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-1566948:r:Elastic fibre formation", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-8948216:r:Collagen chain trimerization", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-SSC-174577:r:Activation of C3 and C5", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-BTA-977606:r:Regulation of Complement cascade", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-432524:r:Degradation of PER", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-CEL-5576892:r:Phase 0 - rapid depolarisation", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-8949275:r:RUNX3 Regulates Immune Response and Cell Migration", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-419037:r:NCAM1 interactions", "R-MMU-173736:r:Alternative complement activation", "R-DME-216083:r:Integrin cell surface interactions", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-216083:r:Integrin cell surface interactions", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-1483206:r:Glycerophospholipid biosynthesis", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-354192:r:Integrin signaling", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-216083:r:Integrin cell surface interactions", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9907900:r:Proteasome assembly", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-3000170:r:Syndecan interactions", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-1566977:r:Fibronectin matrix formation", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-422356:r:Regulation of insulin secretion", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-166663:r:Initial triggering of complement", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-5694530:r:Cargo concentration in the ER", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-216083:r:Integrin cell surface interactions", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-164843:r:2-LTR circle formation", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-5576893:r:Phase 2 - plateau phase", "R-SSC-173736:r:Alternative complement activation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-114608:r:Platelet degranulation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-BTA-173736:r:Alternative complement activation", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-CEL-422356:r:Regulation of insulin secretion", "R-RNO-114608:r:Platelet degranulation", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-174577:r:Activation of C3 and C5", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-DME-216167:r:Nuclear CI is degraded", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-72086:r:mRNA Capping", "R-HSA-2214320:r:Anchoring fibril formation", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-SCE-72086:r:mRNA Capping", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SSC-977606:r:Regulation of Complement cascade", "R-DME-3000170:r:Syndecan interactions", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-DME-445355:r:Smooth Muscle Contraction", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-3000170:r:Syndecan interactions", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-166663:r:Initial triggering of complement", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-GGA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DME-114608:r:Platelet degranulation", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-447041:r:CHL1 interactions", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-173736:r:Alternative complement activation", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-186797:r:Signaling by PDGF", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-2672351:r:Stimuli-sensing channels", "R-CEL-9907900:r:Proteasome assembly", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-9907900:r:Proteasome assembly", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-445355:r:Smooth Muscle Contraction", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-1442490:r:Collagen degradation", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-DDI-9907900:r:Proteasome assembly", "R-DME-446107:r:Type I hemidesmosome assembly", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-BTA-174577:r:Activation of C3 and C5", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-422356:r:Regulation of insulin secretion", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-166663:r:Initial triggering of complement", "R-DDI-1483206:r:Glycerophospholipid biosynthesis", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2214320:r:Anchoring fibril formation", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CEL-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-MMU-9907900:r:Proteasome assembly", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DDI-72086:r:mRNA Capping", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-354192:r:Integrin signaling", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-445144:r:Signal transduction by L1", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-419037:r:NCAM1 interactions", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-MMU-422356:r:Regulation of insulin secretion", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-BTA-114608:r:Platelet degranulation", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-1442490:r:Collagen degradation", "R-HSA-354192:r:Integrin signaling", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-HSA-1566977:r:Fibronectin matrix formation", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-432395:r:Degradation of TIM", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance"], "type": "Domain"}, "IPR002036": {"description": "Endoribonuclease YbeY", "go_ids": ["GO:0006364", "GO:0004222"], "go_terms": ["GO:0006364:rRNA processing:P", 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"R-HSA-381426", "R-SSC-186797", "R-MMU-1474228"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-8949275:r:RUNX3 Regulates Immune Response and Cell Migration", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", 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"R-HSA-5578749", "R-DDI-9615933", "R-HSA-6784531", "R-GGA-1655829", "R-SPO-9615933", "R-DME-5578749", "R-BTA-1655829", "R-BTA-5578749", "R-CEL-9615933", "R-DRE-1655829", "R-MMU-9615933", "R-RNO-1655829", "R-RNO-5578749", "R-DME-9615933", "R-SPO-5578749", "R-HSA-168333", "R-CEL-1655829", "R-DRE-9615933", "R-HSA-9615933", "R-BTA-9615933", "R-HSA-203927", "R-DME-1655829", "R-HSA-165054", "R-MMU-1655829", "R-GGA-9615933", "R-HSA-180746", "R-GGA-5578749"], "pathways": ["R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-DDI-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-GGA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", 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pore complex (NPC) reformation", "R-BTA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-DME-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-GGA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-180746:r:Nuclear import of Rev protein", "R-GGA-5578749:r:Transcriptional regulation by small RNAs"], "type": "Family"}, "IPR002042": {"description": "Uricase", "go_ids": [], "go_terms": [], "name": "Uricase", "pathway_ids": ["PWY-5691"], "pathways": ["PWY-5691:t:urate conversion to allantoin I"], "type": "Family"}, "IPR002043": {"description": "Uracil-DNA glycosylase family 1", "go_ids": ["GO:0004844", "GO:0006284", "GO:0006281"], "go_terms": ["GO:0004844:uracil DNA N-glycosylase activity:F", "GO:0006284:base-excision repair:P", "GO:0006281:DNA repair:P"], 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"go_ids": ["GO:2001070"], "go_terms": ["GO:2001070:starch binding:F"], "name": "CBM20", "pathway_ids": ["R-HSA-6798695", "R-HSA-9013405", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-HSA-3785653", "R-MMU-9013404", "R-RNO-9013423", "R-HSA-9013423", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-8980692", "R-HSA-3322077", "R-MMU-6798695", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-9013408", "R-HSA-1483152", "R-HSA-1483115", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-3322077:r:Glycogen synthesis", "R-MMU-6798695:r:Neutrophil 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"R-XTR-8957275", "R-MMU-9860927", "R-DRE-9013419", "R-HSA-5655253", "R-HSA-5625900", "R-HSA-416572", "R-DME-5673001", "R-HSA-5607763", "R-HSA-9694548", "R-PFA-5687128", "R-RNO-1169408", "R-SCE-6798695", "R-HSA-2029485", "R-DME-9013425", "R-DME-114508", "R-HSA-9013423", "R-RNO-445355", "R-RNO-2025928", "R-MMU-163615", "R-CEL-111932", "R-HSA-111932", "R-HSA-4086398", "R-RNO-451308", "R-SPO-9013420", "R-SSC-9860927", "R-DRE-8957275", "R-HSA-418359", "R-HSA-381038", "R-HSA-5655291", "R-CEL-163560", "R-DME-936837", "R-BTA-3928664", "R-MMU-113501", "R-HSA-936837", "R-HSA-380270", "R-DDI-2514859", "R-RNO-936837", "R-RNO-9856530", "R-XTR-354192", "R-PFA-1660499", "R-MMU-212718", "R-HSA-5654219", "R-HSA-201556", "R-HSA-446388", "R-CEL-2871809", "R-BTA-9856530", "R-SCE-2514859", "R-HSA-8875360", "R-CEL-9856530", "R-HSA-422356", "R-RNO-5627123", "R-GGA-3000471", "R-DDI-9646399"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-BTA-5689880:r:Ub-specific processing proteases", "R-RNO-1483191:r:Synthesis of PC", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-70221:r:Glycogen breakdown (glycogenolysis)", "R-MMU-201556:r:Signaling by ALK", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-MMU-9013419:r:RHOT2 GTPase cycle", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-111997:r:CaM pathway", "R-SCE-193648:r:NRAGE signals death through JNK", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-SSC-114508:r:Effects of PIP2 hydrolysis", "R-SSC-6798695:r:Neutrophil degranulation", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-201451:r:Signaling by BMP", "R-DME-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-DME-111933:r:Calmodulin induced events", "R-DME-1483166:r:Synthesis of PA", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-114608:r:Platelet degranulation", "R-PFA-8847453:r:Synthesis of PIPs in the nucleus", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-HSA-9022535:r:Loss of phosphorylation of MECP2 at T308", "R-MMU-2672351:r:Stimuli-sensing channels", "R-RNO-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-422356:r:Regulation of insulin secretion", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-SPO-202433:r:Generation of second messenger molecules", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-425561:r:Sodium/Calcium exchangers", "R-CEL-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-9619229:r:Activation of RAC1 downstream of NMDARs", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-DME-9856872:r:Malate-aspartate shuttle", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-DRE-1482925:r:Acyl chain remodelling of PG", "R-CFA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-BTA-445355:r:Smooth Muscle Contraction", "R-MMU-6809371:r:Formation of the cornified envelope", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-BTA-9646399:r:Aggrephagy", "R-CEL-9013425:r:RHOT1 GTPase cycle", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-CEL-209968:r:Thyroxine biosynthesis", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-MMU-9648002:r:RAS processing", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-114608:r:Platelet degranulation", "R-CEL-9646399:r:Aggrephagy", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-9856872:r:Malate-aspartate shuttle", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-163615:r:PKA activation", "R-RNO-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-201451:r:Signaling by BMP", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-180024:r:DARPP-32 events", "R-DME-4086398:r:Ca2+ pathway", "R-BTA-8949215:r:Mitochondrial calcium ion transport", "R-RNO-390522:r:Striated Muscle Contraction", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-5578775:r:Ion homeostasis", "R-GGA-75205:r:Dissolution of Fibrin Clot", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-1169092:r:Activation of RAS in B cells", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-2424491:r:DAP12 signaling", "R-GGA-390522:r:Striated Muscle Contraction", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-390522:r:Striated Muscle Contraction", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-111957:r:Cam-PDE 1 activation", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-CEL-3928664:r:Ephrin signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-1483191:r:Synthesis of PC", "R-HSA-167021:r:PLC-gamma1 signalling", "R-RNO-202433:r:Generation of second messenger molecules", "R-DME-2025928:r:Calcineurin activates NFAT", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-445355:r:Smooth Muscle Contraction", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-210990:r:PECAM1 interactions", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-DME-3928664:r:Ephrin signaling", "R-RNO-8949215:r:Mitochondrial calcium ion transport", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-1483191:r:Synthesis of PC", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-114608:r:Platelet degranulation", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-9013408:r:RHOG GTPase cycle", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-9648002:r:RAS processing", "R-GGA-9013419:r:RHOT2 GTPase cycle", "R-MMU-9646399:r:Aggrephagy", "R-DRE-1483166:r:Synthesis of PA", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-392517:r:Rap1 signalling", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6799990:r:Metal sequestration by antimicrobial proteins", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-XTR-1169092:r:Activation of RAS in B cells", "R-SCE-9013420:r:RHOU GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-XTR-392517:r:Rap1 signalling", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-DME-1482925:r:Acyl chain remodelling of PG", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-203615:r:eNOS activation", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-201556:r:Signaling by ALK", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-2160916:r:Hyaluronan degradation", "R-GGA-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-111933:r:Calmodulin induced events", "R-SSC-390522:r:Striated Muscle Contraction", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DME-350416:r:Regulation of non-muscle Myosin II", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-111957:r:Cam-PDE 1 activation", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-CEL-8949664:r:Processing of SMDT1", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-8876725:r:Protein methylation", "R-MMU-1169092:r:Activation of RAS in B cells", "R-SCE-202433:r:Generation of second messenger molecules", "R-DME-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-MMU-203615:r:eNOS activation", "R-MMU-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-6799990:r:Metal sequestration by antimicrobial proteins", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-RNO-2672351:r:Stimuli-sensing channels", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-DME-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-PFA-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-8949215:r:Mitochondrial calcium ion transport", "R-HSA-354192:r:Integrin signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-202433:r:Generation of second messenger molecules", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-SSC-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-BTA-163560:r:Triglyceride catabolism", "R-HSA-163560:r:Triglyceride catabolism", "R-DME-1482801:r:Acyl chain remodelling of PS", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-1483166:r:Synthesis of PA", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8949664:r:Processing of SMDT1", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-2160916:r:Hyaluronan degradation", "R-SCE-445355:r:Smooth Muscle Contraction", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9648002:r:RAS processing", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-PFA-171007:r:p38MAPK events", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-HSA-948021:r:Transport to the Golgi and subsequent modification", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-BTA-201451:r:Signaling by BMP", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-1483166:r:Synthesis of PA", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8949664:r:Processing of SMDT1", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-163615:r:PKA activation", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-111933:r:Calmodulin induced events", "R-SSC-5627123:r:RHO GTPases activate PAKs", "R-RNO-1482925:r:Acyl chain remodelling of PG", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-8949215:r:Mitochondrial calcium ion transport", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-RNO-5694530:r:Cargo concentration in the ER", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-GGA-114608:r:Platelet degranulation", "R-DME-203615:r:eNOS activation", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-DDI-442660:r:SLC-mediated transport of neurotransmitters", "R-CEL-445355:r:Smooth Muscle Contraction", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-6807004:r:Negative regulation of MET activity", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-182971:r:EGFR downregulation", "R-CEL-425561:r:Sodium/Calcium exchangers", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-9856872:r:Malate-aspartate shuttle", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-DME-9619229:r:Activation of RAC1 downstream of NMDARs", "R-DME-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9766229:r:Degradation of CDH1", "R-DME-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-392517:r:Rap1 signalling", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-DME-445095:r:Interaction between L1 and Ankyrins", "R-HSA-9865881:r:Complex III assembly", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-425561:r:Sodium/Calcium exchangers", "R-CEL-114608:r:Platelet degranulation", "R-MMU-8853659:r:RET signaling", "R-DRE-1482788:r:Acyl chain remodelling of PC", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-390522:r:Striated Muscle Contraction", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-RNO-163615:r:PKA activation", "R-DRE-9013425:r:RHOT1 GTPase cycle", "R-HSA-9620244:r:Long-term potentiation", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-CEL-111957:r:Cam-PDE 1 activation", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-422356:r:Regulation of insulin secretion", "R-MMU-6799990:r:Metal sequestration by antimicrobial proteins", "R-DME-1482839:r:Acyl chain remodelling of PE", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-111933:r:Calmodulin induced events", "R-HSA-8873719:r:RAB geranylgeranylation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-RNO-186763:r:Downstream signal transduction", "R-BTA-114608:r:Platelet degranulation", "R-DRE-8949215:r:Mitochondrial calcium ion transport", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-SPO-114604:r:GPVI-mediated activation cascade", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-9648002:r:RAS processing", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DRE-9013408:r:RHOG GTPase cycle", "R-BTA-8949664:r:Processing of SMDT1", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-8876725:r:Protein methylation", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-SSC-6809371:r:Formation of the cornified envelope", "R-SSC-445355:r:Smooth Muscle Contraction", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-RNO-8876725:r:Protein methylation", "R-XTR-9013419:r:RHOT2 GTPase cycle", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-PFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-GGA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DME-1482788:r:Acyl chain remodelling of PC", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-203615:r:eNOS activation", "R-HSA-209968:r:Thyroxine biosynthesis", "R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-4086398:r:Ca2+ pathway", "R-DDI-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-CEL-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9013425:r:RHOT1 GTPase cycle", "R-GGA-445355:r:Smooth Muscle Contraction", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-392517:r:Rap1 signalling", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-MMU-5673000:r:RAF activation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-MMU-209968:r:Thyroxine biosynthesis", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9766229:r:Degradation of CDH1", "R-GGA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-392517:r:Rap1 signalling", "R-MMU-354192:r:Integrin signaling", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-114604:r:GPVI-mediated activation cascade", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-MMU-111957:r:Cam-PDE 1 activation", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-DME-8963693:r:Aspartate and asparagine metabolism", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-BTA-1483166:r:Synthesis of PA", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-201451:r:Signaling by BMP", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-DME-111957:r:Cam-PDE 1 activation", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-BTA-6799990:r:Metal sequestration by antimicrobial proteins", "R-BTA-111447:r:Activation of BAD and translocation to mitochondria", "R-DME-5578775:r:Ion homeostasis", "R-PFA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9768777:r:Regulation of NPAS4 gene transcription", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-112043:r:PLC beta mediated events", "R-BTA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DME-209968:r:Thyroxine biosynthesis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-8949215:r:Mitochondrial calcium ion transport", "R-GGA-9035034:r:RHOF GTPase cycle", "R-XTR-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1483166:r:Synthesis of PA", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-BTA-9013419:r:RHOT2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-CEL-163615:r:PKA activation", "R-DME-5673000:r:RAF activation", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-373753:r:Nephrin family interactions", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-PFA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-BTA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-MMU-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-MMU-425561:r:Sodium/Calcium exchangers", "R-RNO-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-5635838:r:Activation of SMO", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-354192:r:Integrin signaling", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-8949664:r:Processing of SMDT1", "R-MMU-114608:r:Platelet degranulation", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-977225:r:Amyloid fiber formation", "R-SSC-209968:r:Thyroxine biosynthesis", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-1169092:r:Activation of RAS in B cells", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-2160916:r:Hyaluronan degradation", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-RNO-209968:r:Thyroxine biosynthesis", "R-HSA-445355:r:Smooth Muscle Contraction", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-CEL-1483166:r:Synthesis of PA", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-1483191:r:Synthesis of PC", "R-CFA-209968:r:Thyroxine biosynthesis", "R-RNO-4086398:r:Ca2+ pathway", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-5578775:r:Ion homeostasis", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-BTA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-2025928:r:Calcineurin activates NFAT", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-DME-422356:r:Regulation of insulin secretion", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-8949215:r:Mitochondrial calcium ion transport", "R-HSA-1489509:r:DAG and IP3 signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-210990:r:PECAM1 interactions", "R-DDI-416476:r:G alpha (q) signalling events", "R-MMU-9013408:r:RHOG GTPase cycle", "R-DME-445355:r:Smooth Muscle Contraction", "R-RNO-425561:r:Sodium/Calcium exchangers", "R-DDI-114608:r:Platelet degranulation", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-MMU-163560:r:Triglyceride catabolism", "R-HSA-8949664:r:Processing of SMDT1", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-PFA-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-5673000:r:RAF activation", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-DME-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-182971:r:EGFR downregulation", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-BTA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-CEL-9648002:r:RAS processing", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DME-8876725:r:Protein methylation", "R-RNO-163560:r:Triglyceride catabolism", "R-MMU-1483166:r:Synthesis of PA", "R-PFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-111933:r:Calmodulin induced events", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-193648:r:NRAGE signals death through JNK", "R-DDI-8963693:r:Aspartate and asparagine metabolism", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-DDI-202433:r:Generation of second messenger molecules", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-XTR-8957275:r:Post-translational protein phosphorylation", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-9013419:r:RHOT2 GTPase cycle", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-9694548:r:Maturation of spike protein", "R-PFA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-445355:r:Smooth Muscle Contraction", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-MMU-163615:r:PKA activation", "R-CEL-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-4086398:r:Ca2+ pathway", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-SPO-9013420:r:RHOU GTPase cycle", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-CEL-163560:r:Triglyceride catabolism", "R-DME-936837:r:Ion transport by P-type ATPases", "R-BTA-3928664:r:Ephrin signaling", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-XTR-354192:r:Integrin signaling", "R-PFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-201556:r:Signaling by ALK", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-CEL-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-422356:r:Regulation of insulin secretion", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-GGA-3000471:r:Scavenging by Class B Receptors", "R-DDI-9646399:r:Aggrephagy"], "type": "Domain"}, "IPR002049": {"description": "Laminin-type EGF domain", "go_ids": [], "go_terms": [], "name": "LE_dom", "pathway_ids": ["R-HSA-5083632", "R-HSA-8874081", "R-HSA-3000484", "R-MMU-2024096", "R-HSA-3560783", "R-HSA-3000178", "R-BTA-5673001", "R-HSA-9918485", "R-MMU-210993", "R-HSA-9856532", "R-HSA-3656237", "R-DDI-114608", "R-MMU-8957275", "R-DME-350376", "R-RNO-2024096", "R-MMU-975634", "R-HSA-2142845", "R-MMU-3000178", "R-DME-350411", "R-MMU-381426", "R-HSA-5083625", "R-CEL-381426", "R-CEL-8957275", "R-DDI-1474228", "R-HSA-5621480", "R-HSA-446107", "R-RNO-3000178", "R-MMU-5673001", "R-HSA-381426", "R-HSA-1474228", "R-HSA-210993", "R-HSA-3000171", "R-HSA-1971475", "R-HSA-9694614", "R-HSA-373752", "R-HSA-6785807", "R-MMU-2160916", "R-MMU-2142845", "R-HSA-419037", "R-HSA-5673001", "R-HSA-9820960", "R-HSA-3560801", "R-HSA-163125", "R-HSA-2022090", "R-MMU-9913351", "R-DDI-2129379", "R-HSA-4420332", "R-HSA-418890", "R-HSA-376172", "R-DME-373752", "R-MMU-446107", "R-DME-350379", "R-DME-381426", "R-HSA-3000497", "R-DME-8957275", "R-HSA-3000157", "R-HSA-977068", "R-HSA-977225", "R-HSA-418886", "R-HSA-9619665", "R-DME-350368", "R-MMU-3000497", "R-HSA-418885", "R-HSA-373760", "R-HSA-9638630", "R-HSA-3656253", "R-MMU-8874081", "R-HSA-913709", "R-HSA-2024096", "R-MMU-2022928", "R-HSA-9833110", "R-HSA-2022928", "R-RNO-975634", "R-HSA-525793", "R-HSA-9918481", "R-DME-450728", "R-HSA-9925563", "R-HSA-2214320", "R-HSA-5083636", "R-MMU-3000157", "R-HSA-216083", "R-HSA-428542", "R-HSA-9913351", "R-DME-446107", "R-DDI-1566977", "R-DDI-3000178", "R-DME-350480", "R-HSA-2160916", "R-RNO-9913351", "R-RNO-1971475", "R-RNO-2022928", "R-BTA-210993", "R-HSA-8957275", "R-MMU-373752", "R-MMU-1971475", "R-HSA-975634"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-3000178:r:ECM proteoglycans", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-DDI-114608:r:Platelet degranulation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-RNO-2024096:r:HS-GAG degradation", "R-MMU-975634:r:Retinoid metabolism and transport", "R-HSA-2142845:r:Hyaluronan metabolism", "R-MMU-3000178:r:ECM proteoglycans", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-DDI-1474228:r:Degradation of the extracellular matrix", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DDI-2129379:r:Molecules associated with elastic fibres", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-376172:r:DSCAM interactions", "R-DME-373752:r:Netrin-1 signaling", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-3000157:r:Laminin interactions", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-2024096:r:HS-GAG degradation", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-525793:r:Myogenesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-450728:r:Inhibition of actin polymerization", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-MMU-3000157:r:Laminin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-446107:r:Type I hemidesmosome assembly", "R-DDI-1566977:r:Fibronectin matrix formation", "R-DDI-3000178:r:ECM proteoglycans", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-373752:r:Netrin-1 signaling", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Domain"}, "IPR002051": {"description": "Haem oxygenase", "go_ids": ["GO:0004392", "GO:0006788"], "go_terms": ["GO:0004392:heme oxygenase (decyclizing) activity:F", "GO:0006788:heme oxidation:P"], "name": "Haem_Oase", "pathway_ids": ["PWY-5874", "R-RNO-6798695", "R-HSA-6798695", "R-MMU-9707587", "R-SSC-9707587", "R-SSC-189483", "R-MMU-9707564", "R-RNO-917937", "R-MMU-8980692", "R-RNO-8980692", "R-HSA-9660826", "R-RNO-9707564", "R-HSA-9707616", "R-SSC-9609523", "R-HSA-6785807", "R-RNO-9609523", "R-HSA-189483", "R-BTA-9609523", "R-MMU-917937", "R-MMU-189483", "R-HSA-8980692", "R-SSC-9707564", "R-BTA-9707587", "R-HSA-917937", "R-HSA-9707587", "R-HSA-9707564", "R-BTA-917937", "R-BTA-189483", "R-SSC-917937", "R-MMU-6798695", "R-MMU-9609523", "R-HSA-9609523", "R-RNO-189483", "R-RNO-9707587", "R-HSA-844456", "R-HSA-9818027", "R-BTA-9707564"], "pathways": ["PWY-5874:t:heme degradation I", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9707587:r:Regulation of HMOX1 expression and activity", "R-SSC-9707587:r:Regulation of HMOX1 expression and activity", "R-SSC-189483:r:Heme degradation", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707616:r:Heme signaling", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-189483:r:Heme degradation", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-917937:r:Iron uptake and transport", "R-MMU-189483:r:Heme degradation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SSC-9707564:r:Cytoprotection by HMOX1", "R-BTA-9707587:r:Regulation of HMOX1 expression and activity", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9707587:r:Regulation of HMOX1 expression and activity", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-BTA-917937:r:Iron uptake and transport", "R-BTA-189483:r:Heme degradation", "R-SSC-917937:r:Iron uptake and transport", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-189483:r:Heme degradation", "R-RNO-9707587:r:Regulation of HMOX1 expression and activity", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR002053": {"description": "Glycoside hydrolase, family 25", "go_ids": ["GO:0003796", "GO:0009253", "GO:0016998"], "go_terms": ["GO:0003796:lysozyme activity:F", "GO:0009253:peptidoglycan catabolic process:P", "GO:0016998:cell wall macromolecule catabolic process:P"], "name": "Glyco_hydro_25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002054": {"description": "DNA-directed DNA polymerase X", "go_ids": ["GO:0003677", "GO:0003887"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F"], "name": "DNA-dir_DNA_pol_X", "pathway_ids": ["R-BTA-5649702", "R-BTA-110373", "R-MMU-5649702", "R-MMU-5693571", "R-BTA-5689880", "R-DRE-110381", "R-HSA-5689880", "R-DRE-5649702", "R-SCE-110362", "R-RNO-110362", "R-DRE-110373", "R-MMU-110381", "R-HSA-5649702", "R-DRE-110362", "R-RNO-110381", "R-MMU-5689880", "R-MMU-110362", "R-BTA-5651801", "R-BTA-73930", "R-HSA-110373", "R-DRE-5689880", "R-MMU-5651801", "R-HSA-110362", "R-BTA-110381", "R-HSA-5651801", "R-BTA-110362", "R-RNO-5693571", "R-RNO-5689880", "R-RNO-5649702", "R-MMU-110373", "R-HSA-5693571", "R-RNO-73930", "R-HSA-110381", "R-MMU-73930", "R-RNO-5651801", "R-DRE-5651801", "R-DRE-73930", "R-HSA-73930", "R-RNO-110373"], "pathways": ["R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-BTA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DRE-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-SCE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "type": "Domain"}, "IPR002056": {"description": "Protein import receptor MAS20", "go_ids": ["GO:0030150", "GO:0005742", "GO:0006886"], "go_terms": ["GO:0030150:protein import into mitochondrial matrix:P", "GO:0005742:mitochondrial outer membrane translocase complex:C", "GO:0006886:intracellular protein transport:P"], "name": "MAS20", "pathway_ids": ["R-MMU-5205685", "R-DRE-5689880", "R-MMU-5689880", "R-RNO-5205685", "R-HSA-1268020", "R-BTA-5689880", "R-BTA-5205685", "R-HSA-5689880", "R-XTR-5205685", "R-HSA-5205685", "R-CEL-5205685", "R-DRE-5205685", "R-SCE-5205685", "R-RNO-5689880"], "pathways": ["R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5689880:r:Ub-specific processing proteases", "R-XTR-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DRE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SCE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR002058": {"description": "PAP/25A-associated", "go_ids": [], "go_terms": [], "name": "PAP_assoc", "pathway_ids": ["R-HSA-9937008", "R-SPO-9770562", "R-HSA-9820865", "R-HSA-9819196", "R-HSA-9930044", "R-DRE-9770562", "R-HSA-9770562", "R-HSA-6802952", "R-MMU-9770562", "R-HSA-429947", "R-XTR-9770562", "R-RNO-9770562"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-9930044:r:Nuclear RNA decay", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-429947:r:Deadenylation of mRNA", "R-XTR-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation"], "type": "Domain"}, "IPR002059": {"description": "Cold-shock protein Csp, DNA-binding", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "CSP_DNA-bd", "pathway_ids": ["R-RNO-877300", "R-MMU-72203", "R-MMU-9770562", "R-RNO-9017802", "R-HSA-9918487", "R-RNO-72163", "R-HSA-9017802", "R-DRE-72163", "R-DRE-9770562", "R-RNO-72165", "R-DRE-877300", "R-HSA-72165", "R-BTA-877300", "R-HSA-9918481", "R-HSA-2173796", "R-BTA-72163", "R-HSA-72203", "R-BTA-72165", "R-HSA-9770562", "R-RNO-72203", "R-MMU-72163", "R-DRE-72203", "R-HSA-452723", "R-MMU-9017802", "R-MMU-877300", "R-HSA-72163", "R-MMU-72165", "R-HSA-9918476", "R-HSA-877300", "R-RNO-9770562", "R-BTA-9770562", "R-BTA-72203", "R-DRE-72165"], "pathways": ["R-RNO-877300:r:Interferon gamma signaling", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-DRE-9770562:r:mRNA Polyadenylation", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-DRE-877300:r:Interferon gamma signaling", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-877300:r:Interferon gamma signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-877300:r:Interferon gamma signaling", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-877300:r:Interferon gamma signaling", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DRE-72165:r:mRNA Splicing - Minor Pathway"], "type": "Domain"}, "IPR002060": {"description": "Squalene/phytoene synthase", "go_ids": ["GO:0009058"], "go_terms": ["GO:0009058:biosynthetic process:P"], "name": "Squ/phyt_synthse", "pathway_ids": ["R-SCE-9969896", "R-HSA-1989781", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-RNO-9969896", "R-RNO-6799198", "R-DDI-9969896", "R-MMU-9969896", "R-BTA-6799198", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-BTA-6799198:r:Complex I biogenesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR002061": {"description": "Scorpion long chain toxin/defensin", "go_ids": ["GO:0005576", "GO:0008200", "GO:0019871"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0008200:ion channel inhibitor activity:F", "GO:0019871:sodium channel inhibitor activity:F"], "name": "Scorpion_toxinL/defensin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002063": {"description": "Haemerythrin", "go_ids": ["GO:0005506"], "go_terms": ["GO:0005506:iron ion binding:F"], "name": "Haemerythrin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002065": {"description": "Thiol peroxidase Tpx", "go_ids": ["GO:0008379", "GO:0016209"], "go_terms": ["GO:0008379:thioredoxin peroxidase activity:F", "GO:0016209:antioxidant activity:F"], "name": "TPX", "pathway_ids": ["R-HSA-1222541", "R-HSA-1222538"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Family"}, "IPR002068": {"description": "Alpha crystallin/Hsp20 domain", "go_ids": [], "go_terms": [], "name": "A-crystallin/Hsp20_dom", "pathway_ids": ["R-MMU-450408", "R-BTA-450408", "R-BTA-5687128", "R-BTA-3371571", "R-CEL-3371571", "R-MMU-9009391", "R-RNO-9009391", "R-MMU-4420097", "R-MMU-3371571", "R-RNO-5687128", "R-BTA-9009391", "R-HSA-4420097", "R-HSA-9009391", "R-BTA-4420097", "R-HSA-5687128", "R-DME-3371571", "R-HSA-3371571", "R-RNO-3371571", "R-HSA-450408", "R-MMU-5687128", "R-SSC-3371571", "R-RNO-450408", "R-GGA-3371571", "R-RNO-4420097"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-SSC-3371571:r:HSF1-dependent transactivation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-3371571:r:HSF1-dependent transactivation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR002069": {"description": "Interferon gamma", "go_ids": ["GO:0005133", "GO:0005576", "GO:0006955"], "go_terms": ["GO:0005133:type II interferon receptor binding:F", "GO:0005576:extracellular region:C", "GO:0006955:immune response:P"], "name": "Interferon_gamma", "pathway_ids": ["R-RNO-877300", "R-GGA-9732724", "R-HSA-9942503", "R-RNO-9732724", "R-CFA-9732724", "R-HSA-8950505", "R-GGA-877312", "R-SSC-9732724", "R-HSA-9732724", "R-MMU-877300", "R-RNO-877312", "R-CFA-877312", "R-CFA-877300", "R-SSC-877312", "R-HSA-8877330", "R-GGA-877300", "R-BTA-9732724", "R-HSA-877312", "R-MMU-9732724", "R-HSA-877300", "R-SSC-877300", "R-BTA-877300", "R-MMU-877312", "R-BTA-877312"], "pathways": ["R-RNO-877300:r:Interferon gamma signaling", "R-GGA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-CFA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-GGA-877312:r:Regulation of IFNG signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-CFA-877312:r:Regulation of IFNG signaling", "R-CFA-877300:r:Interferon gamma signaling", "R-SSC-877312:r:Regulation of IFNG signaling", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-GGA-877300:r:Interferon gamma signaling", "R-BTA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-BTA-877300:r:Interferon gamma signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-BTA-877312:r:Regulation of IFNG signaling"], "type": "Family"}, "IPR002072": {"description": "Nerve growth 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"R-SSC-1257604", "R-MMU-205017", "R-BTA-9603381", "R-HSA-205017", "R-HSA-167044", "R-HSA-9034015", "R-HSA-209543", "R-RNO-1257604", "R-DRE-205017", "R-BTA-9026527", "R-MMU-205025", "R-HSA-9032759", "R-MMU-9034793", "R-MMU-198203", "R-HSA-9028335", "R-GGA-6811558", "R-GGA-9028731", "R-DRE-209560", "R-RNO-205017", "R-MMU-167060", "R-SSC-9026527", "R-RNO-170984", "R-MMU-205043", "R-HSA-9032845", "R-HSA-9025046", "R-BTA-9034793", "R-HSA-9028731", "R-GGA-1257604", "R-DRE-187042", "R-MMU-9603381", "R-HSA-193648", "R-MMU-209560", "R-RNO-9034793", "R-RNO-9603381", "R-MMU-9028731", "R-HSA-9034864", "R-DRE-170968", "R-MMU-1257604", "R-HSA-9032500", "R-DRE-177504", "R-MMU-209563", "R-HSA-177504", "R-HSA-193681", "R-HSA-9034013", "R-RNO-9032759", "R-HSA-187706", "R-MMU-177504", "R-HSA-170968", "R-RNO-167060", "R-MMU-9032759", "R-HSA-205025", "R-BTA-1257604", "R-BTA-9034013", "R-GGA-9026527", "R-MMU-9026527"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-GGA-9032759:r:NTRK2 activates RAC1", "R-HSA-187042:r:TRKA activation by NGF", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-HSA-198745:r:Signalling to STAT3", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-187042:r:TRKA activation by NGF", "R-RNO-170968:r:Frs2-mediated activation", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DRE-209563:r:Axonal growth stimulation", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-170984:r:ARMS-mediated activation", "R-DRE-170984:r:ARMS-mediated activation", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-HSA-193670:r:p75NTR negatively regulates cell cycle via SC1", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-DRE-167060:r:NGF processing", "R-BTA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-RNO-209563:r:Axonal growth stimulation", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-209563:r:Axonal growth stimulation", "R-SSC-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-HSA-167060:r:NGF processing", "R-MMU-170984:r:ARMS-mediated activation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DRE-198203:r:PI3K/AKT activation", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-MMU-205017:r:NFG and proNGF binds to p75NTR", "R-BTA-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-205017:r:NFG and proNGF binds to p75NTR", "R-HSA-167044:r:Signalling to RAS", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DRE-205017:r:NFG and proNGF binds to p75NTR", "R-BTA-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-205025:r:NADE modulates death signalling", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DRE-209560:r:NF-kB is activated and signals survival", "R-RNO-205017:r:NFG and proNGF binds to p75NTR", "R-MMU-167060:r:NGF processing", "R-SSC-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-170984:r:ARMS-mediated activation", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-BTA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-DRE-187042:r:TRKA activation by NGF", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-DRE-170968:r:Frs2-mediated activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-DRE-177504:r:Retrograde neurotrophin signalling", "R-MMU-209563:r:Axonal growth stimulation", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-193681:r:Ceramide signalling", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-HSA-170968:r:Frs2-mediated activation", "R-RNO-167060:r:NGF processing", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-HSA-205025:r:NADE modulates death signalling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-BTA-9034013:r:NTF3 activates NTRK3 signaling", "R-GGA-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1"], "type": "Domain"}, "IPR002073": {"description": "3'5'-cyclic nucleotide phosphodiesterase, catalytic domain", "go_ids": ["GO:0004114", "GO:0007165"], "go_terms": ["GO:0004114:3',5'-cyclic-nucleotide phosphodiesterase activity:F", "GO:0007165:signal transduction:P"], "name": "PDEase_catalytic_dom", "pathway_ids": ["R-RNO-9013422", "R-MMU-4086398", "R-HSA-2485179", "R-RNO-2514859", "R-MMU-165160", "R-RNO-165160", "R-MMU-445355", "R-DME-445355", "R-DME-9860927", "R-MMU-418457", "R-MMU-111957", "R-DDI-9013422", "R-CEL-418555", "R-RNO-9860927", "R-PFA-418457", "R-HSA-418457", "R-MMU-9013422", "R-DME-418457", "R-RNO-445355", "R-MMU-180024", "R-MMU-2514859", "R-RNO-418457", "R-HSA-4086398", "R-CFA-2485179", "R-CFA-4086398", "R-DDI-418555", "R-HSA-180024", "R-DDI-165160", "R-DDI-2485179", "R-DME-111957", "R-HSA-445355", "R-HSA-2514859", "R-CEL-9860927", "R-CEL-418457", "R-RNO-2485179", "R-PFA-445355", "R-HSA-418555", "R-CFA-445355", "R-BTA-111957", "R-DME-180024", "R-DME-9013422", "R-RNO-180024", "R-BTA-418457", "R-PFA-418555", "R-BTA-9013422", "R-CFA-418457", "R-RNO-4086398", "R-BTA-445355", "R-CEL-180024", "R-CFA-9013422", "R-BTA-418555", "R-DDI-445355", "R-RNO-111957", "R-DDI-4086398", "R-MMU-2485179", "R-HSA-9860927", "R-HSA-111957", "R-SCE-165160", "R-SCE-418555", "R-HSA-165160", "R-PFA-165160", "R-MMU-418555", "R-MMU-9860927", "R-DDI-111957", "R-CEL-165160", "R-DDI-418457", "R-RNO-418555", "R-CEL-111957", "R-HSA-9013422", "R-DME-418555"], "pathways": ["R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-165160:r:PDE3B signalling", "R-RNO-165160:r:PDE3B signalling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-418457:r:cGMP effects", "R-MMU-111957:r:Cam-PDE 1 activation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-418555:r:G alpha (s) signalling events", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-PFA-418457:r:cGMP effects", "R-HSA-418457:r:cGMP effects", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DME-418457:r:cGMP effects", "R-RNO-445355:r:Smooth Muscle Contraction", "R-MMU-180024:r:DARPP-32 events", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-418457:r:cGMP effects", "R-HSA-4086398:r:Ca2+ pathway", "R-CFA-2485179:r:Activation of the phototransduction cascade", "R-CFA-4086398:r:Ca2+ pathway", "R-DDI-418555:r:G alpha (s) signalling events", "R-HSA-180024:r:DARPP-32 events", "R-DDI-165160:r:PDE3B signalling", "R-DDI-2485179:r:Activation of the phototransduction cascade", "R-DME-111957:r:Cam-PDE 1 activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-418457:r:cGMP effects", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-PFA-445355:r:Smooth Muscle Contraction", "R-HSA-418555:r:G alpha (s) signalling events", "R-CFA-445355:r:Smooth Muscle Contraction", "R-BTA-111957:r:Cam-PDE 1 activation", "R-DME-180024:r:DARPP-32 events", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-180024:r:DARPP-32 events", "R-BTA-418457:r:cGMP effects", "R-PFA-418555:r:G alpha (s) signalling events", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-418457:r:cGMP effects", "R-RNO-4086398:r:Ca2+ pathway", "R-BTA-445355:r:Smooth Muscle Contraction", "R-CEL-180024:r:DARPP-32 events", "R-CFA-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-418555:r:G alpha (s) signalling events", "R-DDI-445355:r:Smooth Muscle Contraction", "R-RNO-111957:r:Cam-PDE 1 activation", "R-DDI-4086398:r:Ca2+ pathway", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-111957:r:Cam-PDE 1 activation", "R-SCE-165160:r:PDE3B signalling", "R-SCE-418555:r:G alpha (s) signalling events", "R-HSA-165160:r:PDE3B signalling", "R-PFA-165160:r:PDE3B signalling", "R-MMU-418555:r:G alpha (s) signalling events", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear 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Mature mRNA Derived from an Intronless Transcript", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159230:r:Transport of the SLBP Dependant 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"R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR002076": {"description": "ELO family", "go_ids": ["GO:0016020", "GO:0009922"], "go_terms": ["GO:0016020:membrane:C", "GO:0009922:fatty acid elongase activity:F"], "name": "ELO_fam", "pathway_ids": ["PWY-7602", "PWY-7619", "PWY-5080", "PWY-7725", "PWY-8041", "PWY-7724", "PWY-7036", "PWY-7035", "PWY-7601", "PWY-6598", "PWY-6433", "PWY-5972", "R-RNO-2046105", "R-MMU-2046106", "R-RNO-75876", "R-XTR-75876", "R-RNO-2046106", "R-MMU-75876", "R-BTA-2046106", "R-DME-2046106", "R-HSA-2046105", "R-XTR-2046106", "R-DRE-75876", "R-HSA-9841922", "R-DME-2046105", "R-CEL-2046106", "R-CEL-2046105", "R-CEL-75876", "R-HSA-9844594", "R-BTA-75876", "R-XTR-2046105", "R-DME-75876", "R-HSA-2046106", "R-HSA-75876", "R-HSA-2426168", "R-MMU-2046105", "R-BTA-2046105"], "pathways": ["PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-7619:t:juniperonate biosynthesis", "PWY-5080:t:very long chain fatty acid biosynthesis I", "PWY-7725:t:arachidonate biosynthesis V (8-detaturase, mammals)", "PWY-8041:t:ultra-long-chain fatty acid biosynthesis", "PWY-7724:t:icosapentaenoate biosynthesis III (8-desaturase, mammals)", "PWY-7036:t:very long chain fatty acid biosynthesis II", "PWY-7035:t:(9Z)-tricosene biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-6598:t:sciadonate biosynthesis", "PWY-6433:t:hydroxylated fatty acid biosynthesis (plants)", "PWY-5972:t:stearate biosynthesis I (animals)", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-XTR-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-XTR-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DRE-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-2046105:r:Linoleic acid (LA) metabolism", "R-CEL-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-CEL-2046105:r:Linoleic acid (LA) metabolism", "R-CEL-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-XTR-2046105:r:Linoleic acid (LA) metabolism", "R-DME-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-BTA-2046105:r:Linoleic acid (LA) metabolism"], "type": "Family"}, "IPR002077": {"description": "Voltage-dependent calcium channel, alpha-1 subunit", "go_ids": ["GO:0005245", "GO:0070588", "GO:0005891"], "go_terms": ["GO:0005245:voltage-gated calcium channel activity:F", "GO:0070588:calcium ion transmembrane transport:P", "GO:0005891:voltage-gated calcium channel complex:C"], "name": "VDCCAlpha1", "pathway_ids": ["R-DME-5576893", "R-RNO-5576893", "R-HSA-445355", "R-GGA-422356", "R-DME-422356", "R-SPO-445355", "R-MMU-422356", "R-RNO-112308", "R-MMU-5576892", "R-HSA-400042", "R-HSA-5576892", "R-HSA-419037", "R-RNO-422356", "R-MMU-5576893", "R-HSA-9662360", "R-HSA-5576893", "R-DME-5576892", "R-HSA-112308", "R-MMU-112308", "R-RNO-5576892", "R-HSA-422356"], "pathways": ["R-DME-5576893:r:Phase 2 - plateau phase", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-HSA-445355:r:Smooth Muscle Contraction", 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"Family"}, "IPR002078": {"description": "RNA polymerase sigma factor 54 interaction domain", "go_ids": ["GO:0005524", "GO:0006355", "GO:0008134"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0008134:transcription factor binding:F"], "name": "Sigma_54_int", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002079": {"description": "Gag polyprotein, inner coat protein p12", "go_ids": [], "go_terms": [], "name": "Gag_p12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002081": {"description": "Cryptochrome/DNA photolyase class 1", "go_ids": [], "go_terms": [], "name": "Cryptochrome/DNA_photolyase_1", "pathway_ids": ["R-HSA-9931510", "R-DME-432553", "R-DME-432395", "R-HSA-9931530", "R-HSA-9932298", "R-HSA-9931521", "R-DME-538864"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-DME-432553:r:Phosphorylation of PER and TIM", 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NF-kappa-B activation", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-SSC-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-XTR-5632684:r:Hedgehog 'on' state", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DRE-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DRE-209560:r:NF-kB is activated and signals survival", "R-SSC-5689880:r:Ub-specific processing proteases", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-RNO-8948747:r:Regulation of PTEN localization", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-202424:r:Downstream TCR signaling", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Domain"}, "IPR002084": {"description": "Methionine repressor MetJ", "go_ids": ["GO:0003700", "GO:0006355", "GO:0006555"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0006555:L-methionine metabolic process:P"], "name": "Met_repressor_MetJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002087": {"description": "Anti-proliferative protein", "go_ids": [], "go_terms": [], "name": "Anti_prolifrtn", "pathway_ids": ["R-MMU-6804115", "R-DDI-6804115", "R-HSA-6804115", "R-HSA-9617828", "R-HSA-9820841", "R-RNO-6804115"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DDI-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Domain"}, "IPR002088": {"description": "Protein prenyltransferase, alpha subunit", "go_ids": ["GO:0008318", "GO:0018342"], "go_terms": ["GO:0008318:protein prenyltransferase activity:F", "GO:0018342:protein prenylation:P"], "name": "Prenyl_trans_a", "pathway_ids": ["R-SPO-6803205", "R-BTA-8873719", "R-RNO-9953170", "R-MMU-6803205", "R-DDI-8873719", "R-HSA-2514859", "R-MMU-9648002", "R-HSA-8873719", "R-SCE-8873719", "R-SCE-6803205", "R-HSA-9679191", "R-HSA-6803205", "R-DDI-9648002", "R-MMU-9953170", "R-RNO-111465", "R-MMU-8873719", "R-BTA-6803205", "R-RNO-6803205", "R-RNO-8873719", "R-SPO-9648002", "R-MMU-2514859", "R-MMU-111465", "R-SPO-8873719", "R-HSA-111465", "R-RNO-9648002", "R-DDI-6803205", "R-HSA-9648002", "R-DDI-9953170", "R-RNO-2514859", "R-HSA-9953170", "R-SCE-9648002"], "pathways": ["R-SPO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-BTA-8873719:r:RAB geranylgeranylation", "R-RNO-9953170:r:GBP-mediated host defense", "R-MMU-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DDI-8873719:r:RAB geranylgeranylation", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-9648002:r:RAS processing", "R-HSA-8873719:r:RAB geranylgeranylation", "R-SCE-8873719:r:RAB geranylgeranylation", "R-SCE-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DDI-9648002:r:RAS processing", "R-MMU-9953170:r:GBP-mediated host defense", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-8873719:r:RAB geranylgeranylation", "R-BTA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-RNO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-RNO-8873719:r:RAB geranylgeranylation", "R-SPO-9648002:r:RAS processing", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-SPO-8873719:r:RAB geranylgeranylation", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-9648002:r:RAS processing", "R-DDI-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-9648002:r:RAS processing", "R-DDI-9953170:r:GBP-mediated host defense", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-9953170:r:GBP-mediated host defense", "R-SCE-9648002:r:RAS processing"], "type": "Repeat"}, "IPR002089": {"description": "Influenza virus matrix protein 2", "go_ids": ["GO:0015078", "GO:1902600", "GO:0033644", "GO:0055036"], "go_terms": ["GO:0015078:proton transmembrane transporter activity:F", "GO:1902600:proton transmembrane transport:P", "GO:0033644:host cell membrane:C", "GO:0055036:virion membrane:C"], "name": "Flu_M2", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168288", "R-HSA-168275", "R-HSA-168316", "R-HSA-168298", "R-HSA-168874", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-168298:r:Release", "R-HSA-168874:r:Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Family"}, "IPR002092": {"description": "DNA-directed RNA polymerase, phage-type", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "DNA-dir_Rpol_phage-type", "pathway_ids": ["R-MMU-9913635", "R-MMU-163282", "R-SPO-163282", "R-HSA-2151201", "R-SCE-163282", "R-HSA-163282", "R-HSA-9913635"], "pathways": ["R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-163282:r:Mitochondrial transcription initiation", "R-SPO-163282:r:Mitochondrial transcription initiation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SCE-163282:r:Mitochondrial transcription initiation", "R-HSA-163282:r:Mitochondrial transcription initiation", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Family"}, "IPR002093": {"description": "BRCA2 repeat", "go_ids": [], "go_terms": [], "name": "BRCA2_repeat", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-RNO-5693579", "R-HSA-9704646", "R-RNO-5685939", "R-HSA-9709603", "R-MMU-5693616", "R-MMU-5685942", "R-HSA-5685939", "R-HSA-9709275", "R-RNO-5685942", "R-HSA-9709570", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-912446", "R-HSA-9763198", "R-MMU-5685939", "R-MMU-5693568", "R-RNO-5693616", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709275:r:Impaired BRCA2 translocation to the nucleus", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-912446:r:Meiotic recombination", "R-HSA-9763198:r:Impaired BRCA2 binding to SEM1 (DSS1)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Repeat"}, "IPR002099": {"description": "DNA mismatch repair protein MutL/Mlh/PMS", "go_ids": ["GO:0005524", "GO:0006298", "GO:0030983"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006298:mismatch repair:P", "GO:0030983:mismatched DNA binding:F"], "name": "MutL/Mlh/PMS", "pathway_ids": ["R-GGA-5358565", "R-RNO-5358565", "R-HSA-5545483", "R-SCE-5358565", "R-SPO-5358565", "R-HSA-912446", "R-HSA-5358606", "R-HSA-5358565", "R-DDI-5358565", "R-HSA-6796648", "R-MMU-5358565", "R-HSA-5632987"], "pathways": ["R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632987:r:Defective Mismatch Repair Associated With PMS2"], "type": "Family"}, "IPR002100": {"description": "Transcription factor, MADS-box", "go_ids": ["GO:0003677", "GO:0046983"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0046983:protein dimerization activity:F"], "name": "TF_MADSbox", "pathway_ids": ["R-HSA-198753", "R-SPO-9031628", "R-HSA-2151201", "R-HSA-9768777", "R-HSA-9707616", "R-DME-525793", "R-HSA-9931509", "R-HSA-9634638", "R-MMU-9031628", "R-CEL-525793", "R-RNO-525793", "R-BTA-525793", "R-SCE-525793", "R-HSA-9733709", "R-DDI-525793", "R-HSA-5663220", "R-MMU-525793", "R-DME-5663220", "R-HSA-9031628", "R-DDI-9031628", "R-CEL-9031628", "R-HSA-525793", "R-SPO-525793", "R-MMU-5663220", "R-SCE-9031628", "R-HSA-9022707"], "pathways": ["R-HSA-198753:r:ERK/MAPK targets", "R-SPO-9031628:r:NGF-stimulated transcription", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9768777:r:Regulation of NPAS4 gene transcription", "R-HSA-9707616:r:Heme signaling", "R-DME-525793:r:Myogenesis", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9031628:r:NGF-stimulated transcription", "R-CEL-525793:r:Myogenesis", "R-RNO-525793:r:Myogenesis", "R-BTA-525793:r:Myogenesis", "R-SCE-525793:r:Myogenesis", "R-HSA-9733709:r:Cardiogenesis", "R-DDI-525793:r:Myogenesis", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-525793:r:Myogenesis", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-HSA-9031628:r:NGF-stimulated transcription", "R-DDI-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-525793:r:Myogenesis", "R-SPO-525793:r:Myogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-SCE-9031628:r:NGF-stimulated transcription", "R-HSA-9022707:r:MECP2 regulates transcription factors"], "type": "Domain"}, "IPR002101": {"description": "Myristoylated alanine-rich C-kinase substrate MARCKS", "go_ids": ["GO:0005516"], "go_terms": ["GO:0005516:calmodulin binding:F"], "name": "MARCKS", "pathway_ids": ["R-HSA-399997", "R-RNO-399997", "R-MMU-399997"], "pathways": ["R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-MMU-399997:r:Acetylcholine regulates insulin secretion"], "type": "Family"}, "IPR002102": {"description": "Cellulosome anchoring protein, cohesin domain", "go_ids": ["GO:0000272", "GO:0030246"], "go_terms": ["GO:0000272:polysaccharide catabolic process:P", "GO:0030246:carbohydrate binding:F"], "name": "Cohesin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002104": {"description": "Integrase, catalytic domain", "go_ids": ["GO:0003677", "GO:0006310", "GO:0015074"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006310:DNA recombination:P", "GO:0015074:DNA integration:P"], "name": "Integrase_catalytic", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002105": {"description": "Dockerin type I repeat", "go_ids": ["GO:0000272", "GO:0004553"], "go_terms": ["GO:0000272:polysaccharide catabolic process:P", "GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "Dockerin_1_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR002107": {"description": "Rotavirus non-structural protein 4", "go_ids": [], "go_terms": [], "name": "Rotavirus_NSP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002108": {"description": "Actin-depolymerising factor homology domain", "go_ids": ["GO:0003779"], "go_terms": ["GO:0003779:actin binding:F"], "name": "ADF-H", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-HSA-9013405", "R-HSA-9013422", "R-HSA-9013418", "R-DME-6798695", "R-HSA-9662361", "R-SCE-6798695", "R-HSA-8950505", "R-BTA-6798695", "R-HSA-2029482", "R-HSA-3928662", "R-RNO-9013418", "R-DME-9013418", "R-HSA-6794361", "R-HSA-114608", "R-HSA-9662360", "R-HSA-399954", "R-XTR-9013418", "R-MMU-6798695", "R-HSA-264870", "R-MMU-9013418", "R-DDI-9013418", "R-RNO-6798695", "R-HSA-9013407", "R-HSA-5627117"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-XTR-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Domain"}, "IPR002109": {"description": "Glutaredoxin", "go_ids": [], "go_terms": [], "name": "Glutaredoxin", "pathway_ids": ["R-HSA-1989781", "R-HSA-3299685", "R-HSA-1362409", "R-SSC-499943", "R-SCE-1362409", "R-HSA-9662361", "R-SPO-1362409", "R-HSA-5263617", "R-DDI-1362409", "R-HSA-2408550", "R-HSA-499943", "R-HSA-5628897", "R-MMU-499943", "R-HSA-5336415", "R-HSA-9662360", "R-HSA-917937", "R-MMU-1362409", "R-RNO-499943", "R-HSA-9818027"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SSC-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-DDI-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-917937:r:Iron uptake and transport", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes"], "type": "Domain"}, "IPR002110": {"description": "Ankyrin repeat", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Ankyrin_rpt", "pathway_ids": ["R-HSA-9013405", "R-HSA-9604323", "R-HSA-2559580", "R-HSA-8951664", "R-SCE-204005", "R-MMU-6804756", "R-HSA-69231", "R-MMU-8948751", "R-MMU-933542", "R-MMU-5685938", "R-RNO-193692", "R-DME-8948751", "R-CEL-446343", "R-MMU-69473", "R-MMU-5689880", "R-MMU-1912420", "R-HSA-3134963", "R-HSA-9818030", "R-HSA-9662360", "R-RNO-77289", "R-MMU-1810476", "R-DME-214869", "R-RNO-139853", "R-CEL-8964539", "R-DME-5676590", "R-RNO-1912420", "R-DME-214842", "R-HSA-2691232", "R-GGA-1227892", "R-MMU-909733", "R-HSA-9013507", "R-RNO-446343", "R-HSA-9931295", "R-HSA-77289", "R-HSA-170984", "R-MMU-9930044", "R-MMU-9035034", "R-DME-4641257", "R-HSA-5607761", "R-MMU-9013407", "R-HSA-983695", "R-CEL-2979096", "R-BTA-2559585", "R-RNO-8963693", "R-CEL-2995383", "R-CEL-139853", "R-XTR-9013507", "R-HSA-196807", "R-MMU-201681", "R-HSA-192105", "R-HSA-373752", "R-MMU-2151201", "R-RNO-3214841", "R-CFA-9013407", "R-MMU-171319", "R-HSA-8964539", "R-RNO-9764725", "R-MMU-448706", "R-DDI-5674135", "R-HSA-909733", "R-HSA-2660826", "R-HSA-6804756", "R-MMU-5357905", "R-HSA-1482839", "R-MMU-8963693", "R-RNO-5621575", "R-MMU-9696264", "R-RNO-9013420", "R-DME-3134963", "R-HSA-201681", "R-DME-202424", "R-SSC-6798695", "R-HSA-8941856", "R-CEL-210500", "R-HSA-5625740", "R-HSA-6803205", "R-XTR-2122948", "R-DDI-5674499", "R-HSA-9824272", "R-RNO-3134963", "R-RNO-9860927", "R-DRE-983168", "R-MMU-5693565", "R-MMU-193692", "R-HSA-9907900", "R-GGA-5627123", "R-RNO-2565942", "R-MMU-2672351", "R-SSC-933542", "R-MMU-2132295", "R-HSA-9013148", "R-DME-214416", "R-HSA-9627069", "R-MMU-5693579", "R-HSA-6811436", "R-DDI-5689880", "R-HSA-9701192", "R-MMU-114508", "R-HSA-1912420", "R-DDI-9833482", "R-HSA-8983711", "R-RNO-2132295", "R-MMU-209560", "R-HSA-9696270", "R-HSA-210744", "R-DME-5578775", "R-RNO-210500", "R-DDI-936440", "R-HSA-381340", "R-DME-6798695", "R-MMU-210500", "R-SSC-5607764", "R-MMU-9013424", "R-HSA-9709603", "R-DDI-5675221", "R-HSA-1482798", "R-RNO-3928664", "R-MMU-5676590", "R-RNO-9013423", "R-RNO-5685942", "R-HSA-446353", "R-DRE-2565942", "R-RNO-983695", "R-HSA-427389", "R-DME-9020702", "R-RNO-5357786", "R-MMU-9696273", "R-CEL-8951664", "R-HSA-6798695", "R-XTR-2979096", "R-HSA-2151201", "R-RNO-9020702", "R-RNO-2559582", "R-HSA-5693616", "R-MMU-5689901", "R-MMU-2122948", "R-MMU-5625740", "R-RNO-5357905", "R-BTA-6798695", "R-MMU-2565942", "R-HSA-139915", "R-DDI-8951664", "R-DDI-5675482", "R-DDI-170968", "R-MMU-8951664", "R-RNO-350054", "R-MMU-445989", "R-DRE-77289", "R-HSA-5693607", "R-DRE-6798695", "R-HSA-446343", "R-MMU-2029485", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-9013408", "R-DME-214844", "R-SSC-445989", "R-RNO-1482839", "R-DRE-9696270", "R-MMU-9013700", "R-HSA-447043", "R-HSA-5603029", "R-BTA-114508", "R-MMU-5620916", "R-HSA-209560", "R-MMU-5621575", "R-BTA-2559580", "R-SSC-1169091", "R-RNO-5620916", "R-BTA-2559582", "R-RNO-5693579", "R-HSA-3928664", "R-CEL-5628897", "R-HSA-8963693", "R-RNO-5693607", "R-HSA-8876198", "R-GGA-434131", "R-HSA-9673768", "R-MMU-2559580", "R-DDI-77289", "R-HSA-5357786", "R-RNO-69473", "R-HSA-204005", "R-HSA-9013695", "R-MMU-8876198", "R-MMU-445095", "R-MMU-4641257", "R-MMU-9013406", "R-MMU-6798695", "R-DME-5607764", "R-RNO-6794361", "R-DME-209406", "R-MMU-5693571", "R-XTR-9017802", "R-DME-2871837", "R-HSA-844456", "R-RNO-2559585", "R-RNO-933542", "R-HSA-9013407", "R-SSC-209560", "R-HSA-2132295", "R-HSA-9930044", "R-MMU-9856530", "R-DRE-9696273", "R-HSA-9704646", "R-HSA-977225", "R-MMU-6807878", "R-DME-9013424", "R-HSA-8953750", "R-HSA-6794361", "R-HSA-171319", 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"R-DDI-5213460", "R-MMU-9013420", "R-HSA-8853659", "R-MMU-1482788", "R-DDI-5673000", "R-DME-3928664", "R-HSA-447038", "R-HSA-2122947", "R-HSA-210500", "R-MMU-6804760", "R-DME-9013149", "R-MMU-3214841", "R-HSA-69473", "R-RNO-5628897", "R-HSA-9660826", "R-MMU-2559582", "R-CFA-3295583", "R-HSA-9764725", "R-HSA-9609690", "R-MMU-1482839", "R-HSA-6804760", "R-RNO-5693571", "R-HSA-447041", "R-RNO-5689880", "R-HSA-9696264", "R-RNO-6811436", "R-MMU-9013423", "R-SPO-192105", "R-MMU-350054", "R-RNO-8951664", "R-RNO-5693568", "R-HSA-9793380", "R-HSA-9013026", "R-MMU-5627123", "R-HSA-2644606", "R-HSA-9768727", "R-MMU-9860927", "R-RNO-6798695", "R-HSA-1482788", "R-HSA-9699150", "R-GGA-983168", "R-DME-983168", "R-HSA-5625900", "R-HSA-5685942", "R-HSA-445095", "R-DME-2995383", "R-MMU-8980692", "R-HSA-933542", "R-MMU-2122947", "R-XTR-8941856", "R-HSA-2029485", "R-DME-114508", "R-CEL-983168", "R-XTR-1912420", "R-HSA-9013423", "R-HSA-5620916", "R-HSA-5357905", "R-RNO-8964539", "R-HSA-9013700", "R-MMU-9013507", "R-RNO-5685938", "R-HSA-9843970", "R-SSC-9020702", "R-SSC-9860927", "R-MMU-6804759", "R-HSA-5693568", "R-MMU-5693607", "R-MMU-202424", "R-MMU-8983711", "R-MMU-3928664", "R-DME-3295583", "R-DME-214411", "R-SCE-3295583", "R-DDI-9907900", "R-DDI-392517", "R-MMU-1169091", "R-HSA-2995383", "R-MMU-9017802", "R-HSA-350054", "R-MMU-447043", "R-MMU-5607761", "R-RNO-69231", "R-SSC-202424", "R-RNO-9856530", "R-DME-445989", "R-HSA-5693571", "R-HSA-9909649", "R-DME-214399", "R-HSA-9856530", "R-MMU-9013149", "R-HSA-5693579", "R-HSA-1912399", "R-MMU-2559585", "R-DME-9013420", "R-HSA-9927426", "R-BTA-983168", "R-RNO-5627123", "R-HSA-1989781", "R-MMU-446353", "R-BTA-69231", "R-HSA-139853", "R-MMU-204005", "R-MMU-8953750", "R-RNO-2995383", "R-MMU-5607764", "R-DME-209560", "R-DME-8951664", "R-DME-5621575", "R-DRE-8951664", "R-SSC-1810476", "R-RNO-9013149", "R-HSA-9818749", "R-MMU-5693616", "R-HSA-5676590", "R-HSA-9013424", "R-MMU-9013404", "R-RNO-448706", "R-DME-933542", "R-HSA-9927418", "R-HSA-5545619", "R-RNO-1482788", "R-HSA-9709570", "R-RNO-2029485", "R-RNO-5625740", "R-CEL-114508", "R-RNO-9013424", "R-HSA-4641257", "R-RNO-202424", "R-MMU-5628897", "R-MMU-5693568", "R-BTA-446343", "R-RNO-9013406", "R-SCE-192105", "R-HSA-9018519", "R-HSA-5601884", "R-HSA-9663199", "R-DRE-170984", "R-MMU-5684264", "R-MMU-9907900", "R-RNO-8853659", "R-MMU-192105", "R-RNO-209560", "R-MMU-8853659", "R-MMU-5578775", "R-RNO-9013507", "R-RNO-9696273", "R-CEL-446353", "R-MMU-9604323", "R-MMU-6811436", "R-HSA-9013404", "R-RNO-9931295", "R-HSA-9013149", "R-HSA-1169091", "R-HSA-8980692", "R-MMU-2871837", "R-HSA-2644607", "R-HSA-9704331", "R-MMU-77289", "R-RNO-445989", "R-HSA-8948751", "R-HSA-418890", "R-HSA-5689603", "R-HSA-9860927", "R-HSA-5693554", "R-RNO-5693616", "R-RNO-983168", "R-HSA-193692", "R-HSA-445989", "R-MMU-69231", "R-HSA-8853884", "R-HSA-5689901", "R-BTA-8951664", "R-MMU-196807", "R-DME-1169091", "R-MMU-139853", "R-MMU-73762", "R-HSA-2122948", "R-RNO-9696270", "R-RNO-9017802", "R-DME-1810476", "R-HSA-2559585", "R-HSA-418889", "R-DDI-8849471", "R-HSA-2559582", "R-DME-9860927", "R-HSA-5628897", "R-HSA-1912408", "R-HSA-9017802", "R-SCE-8948751", "R-RNO-3295583", "R-DME-5620916", "R-HSA-448706", "R-HSA-3214841", "R-HSA-9954709", "R-BTA-139853", "R-DME-5607761", "R-SSC-5689880", "R-HSA-5578775", "R-DME-209394", "R-MMU-5689603", "R-HSA-9920951", "R-RNO-6804756", "R-MMU-446343", "R-RNO-170984", "R-HSA-9619229", "R-HSA-5607764", "R-HSA-2173796", "R-DDI-1169408", "R-MMU-5357786", "R-HSA-9013508", "R-HSA-9013420", "R-MMU-8964539", "R-HSA-9662361", "R-MMU-6794361", "R-HSA-6807878", "R-RNO-5684264", "R-MMU-5685942", "R-MMU-983695", "R-RNO-4755510", "R-DDI-5621575", "R-HSA-1810476", "R-DDI-983168", "R-DDI-9909505", "R-CEL-3295583", "R-BTA-2151201", "R-HSA-6803204", "R-MMU-9013026", "R-MMU-8941856", "R-MMU-983168", "R-HSA-9022699", "R-DDI-168638", "R-MMU-9696270", "R-MMU-3295583", "R-HSA-9696273", "R-HSA-5627117"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8951664:r:Neddylation", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-CEL-139853:r:Elevation of cytosolic Ca2+ levels", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-CFA-9013407:r:RHOH GTPase cycle", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-448706:r:Interleukin-1 processing", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-202424:r:Downstream TCR signaling", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9824272:r:Somitogenesis", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-9907900:r:Proteasome assembly", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-2672351:r:Stimuli-sensing channels", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-DDI-9833482:r:PKR-mediated signaling", "R-HSA-8983711:r:OAS antiviral response", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-DME-5578775:r:Ion homeostasis", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-9020702:r:Interleukin-1 signaling", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-DDI-8951664:r:Neddylation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DDI-170968:r:Frs2-mediated activation", "R-MMU-8951664:r:Neddylation", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-DRE-9696270:r:RND2 GTPase cycle", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-3928664:r:Ephrin signaling", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-6794361:r:Neurexins and neuroligins", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-XTR-9017802:r:Noncanonical activation of NOTCH3", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-HSA-844456:r:The NLRP3 inflammasome", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-9930044:r:Nuclear RNA decay", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DRE-9696273:r:RND1 GTPase cycle", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-SSC-4755510:r:SUMOylation of immune response proteins", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-RNO-5689603:r:UCH proteinases", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-BTA-3295583:r:TRP channels", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-9907900:r:Proteasome assembly", "R-CEL-6794361:r:Neurexins and neuroligins", "R-DDI-3295583:r:TRP channels", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-DME-9013423:r:RAC3 GTPase cycle", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-3295583:r:TRP channels", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9020702:r:Interleukin-1 signaling", "R-BTA-446353:r:Cell-extracellular matrix interactions", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5689901:r:Metalloprotease DUBs", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-DDI-5673000:r:RAF activation", "R-DME-3928664:r:Ephrin signaling", "R-HSA-447038:r:NrCAM interactions", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CFA-3295583:r:TRP channels", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-447041:r:CHL1 interactions", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-SPO-192105:r:Synthesis of bile acids and bile salts", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-RNO-8951664:r:Neddylation", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-HSA-9699150:r:Defective DNA double strand break response due to BARD1 loss of function", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-SSC-9020702:r:Interleukin-1 signaling", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-8983711:r:OAS antiviral response", "R-MMU-3928664:r:Ephrin signaling", "R-DME-3295583:r:TRP channels", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-SCE-3295583:r:TRP channels", "R-DDI-9907900:r:Proteasome assembly", "R-DDI-392517:r:Rap1 signalling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-447043:r:Neurofascin interactions", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-SSC-202424:r:Downstream TCR signaling", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-DME-9013420:r:RHOU GTPase cycle", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-BTA-69231:r:Cyclin D associated events in G1", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209560:r:NF-kB is activated and signals survival", "R-DME-8951664:r:Neddylation", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-8951664:r:Neddylation", "R-SSC-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-448706:r:Interleukin-1 processing", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-5545619:r:XAV939 stabilizes AXIN", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-SCE-192105:r:Synthesis of bile acids and bile salts", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-HSA-9663199:r:Defective DNA double strand break response due to BRCA1 loss of function", "R-DRE-170984:r:ARMS-mediated activation", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9907900:r:Proteasome assembly", "R-RNO-8853659:r:RET signaling", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-MMU-8853659:r:RET signaling", "R-MMU-5578775:r:Ion homeostasis", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the 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proteinases", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-5689901:r:Metalloprotease DUBs", "R-BTA-8951664:r:Neddylation", "R-MMU-196807:r:Nicotinate metabolism", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9696270:r:RND2 GTPase cycle", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-RNO-3295583:r:TRP channels", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-448706:r:Interleukin-1 processing", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-139853:r:Elevation of cytosolic Ca2+ levels", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-SSC-5689880:r:Ub-specific processing proteases", "R-HSA-5578775:r:Ion homeostasis", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-MMU-5689603:r:UCH proteinases", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-9013420:r:RHOU GTPase cycle", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-4755510:r:SUMOylation of immune response proteins", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-3295583:r:TRP channels", "R-BTA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-9013026:r:RHOB GTPase 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"R-MMU-83936", "R-SPO-1268020", "R-BTA-166187", "R-CEL-200425", "R-DME-83936", "R-MMU-166187", "R-SCE-166187", "R-HSA-1268020", "R-SPO-166187", "R-BTA-9837999", "R-BTA-1268020", "R-SCE-9837999", "R-HSA-166187", "R-SPO-9837999", "R-SSC-9837999", "R-SCE-83936", "R-BTA-83936", "R-SCE-1268020", "R-HSA-9837999", "R-HSA-168277", "R-HSA-180897", "R-DME-1268020", "R-SPO-83936", "R-DDI-166187"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-DDI-1268020:r:Mitochondrial protein import", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-SSC-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-DDI-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-DME-9837999:r:Mitochondrial protein degradation", "R-SSC-1268020:r:Mitochondrial protein import", "R-RNO-166187:r:Mitochondrial Uncoupling", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-SPO-1268020:r:Mitochondrial protein import", "R-BTA-166187:r:Mitochondrial Uncoupling", "R-CEL-200425:r:Carnitine shuttle", "R-DME-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-MMU-166187:r:Mitochondrial Uncoupling", "R-SCE-166187:r:Mitochondrial Uncoupling", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-166187:r:Mitochondrial Uncoupling", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-BTA-1268020:r:Mitochondrial protein import", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-166187:r:Mitochondrial Uncoupling", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SSC-9837999:r:Mitochondrial 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"R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR002125": {"description": "Cytidine and deoxycytidylate deaminase domain", "go_ids": [], "go_terms": [], "name": "CMP_dCMP_dom", "pathway_ids": ["R-RNO-72200", "R-HSA-6798695", "R-SPO-6798695", "R-DDI-6798695", "R-HSA-73614", "R-SPO-73614", "R-SCE-6798695", "R-RNO-75094", "R-SCE-499943", "R-MMU-73614", "R-MMU-75094", "R-SPO-499943", "R-HSA-499943", "R-HSA-180689", "R-HSA-75094", "R-MMU-499943", "R-HSA-180585", "R-DME-499943", "R-MMU-72200", "R-HSA-6782315", "R-RNO-499943", "R-HSA-9821002", "R-HSA-72200", "R-CEL-499943", "R-MMU-6798695", "R-SCE-73614", "R-DDI-73614"], "pathways": ["R-RNO-72200:r:mRNA Editing: C to U Conversion", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-73614:r:Pyrimidine salvage", "R-SPO-73614:r:Pyrimidine salvage", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-75094:r:Formation of the Editosome", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-73614:r:Pyrimidine salvage", "R-MMU-75094:r:Formation of the Editosome", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-75094:r:Formation of the Editosome", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-72200:r:mRNA Editing: C to U Conversion", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-72200:r:mRNA Editing: C to U Conversion", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-73614:r:Pyrimidine salvage", "R-DDI-73614:r:Pyrimidine salvage"], "type": "Domain"}, "IPR002126": {"description": "Cadherin-like", "go_ids": ["GO:0005509", "GO:0007156", "GO:0016020"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0007156:homophilic cell-cell adhesion:P", "GO:0016020:membrane:C"], "name": "Cadherin-like_dom", "pathway_ids": ["R-HSA-6798695", "R-DRE-9768727", "R-RNO-1474228", "R-CEL-6798695", "R-MMU-9013408", "R-HSA-9766229", "R-MMU-9013404", "R-HSA-351906", "R-HSA-9927418", "R-MMU-8957275", "R-DME-350376", "R-RNO-525793", "R-HSA-9764562", "R-HSA-418990", "R-DME-390150", "R-HSA-9764561", "R-DRE-5626467", "R-HSA-5218920", "R-HSA-8853659", "R-DRE-6798695", "R-HSA-9823730", "R-MMU-381426", "R-HSA-9662360", "R-GGA-8957275", "R-HSA-9926550", "R-CFA-418990", "R-HSA-9759811", "R-DRE-418990", "R-RNO-6805567", "R-DME-350411", "R-HSA-9013408", "R-RNO-9768727", "R-DRE-9696270", "R-RNO-5673001", "R-MMU-5673001", "R-DME-390023", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-BTA-418990", "R-SSC-418990", "R-DRE-5218920", "R-DME-8980692", "R-CFA-351906", "R-RNO-8853659", "R-HSA-9830364", "R-DRE-6805567", "R-DRE-9764561", "R-DME-114608", "R-MMU-8853659", "R-SSC-351906", "R-CFA-6805567", "R-MMU-351906", "R-DME-6809371", "R-GGA-525793", "R-MMU-9762292", "R-HSA-5673001", "R-HSA-9696264", "R-MMU-9013423", "R-HSA-9013404", "R-RNO-381426", "R-DRE-9766229", "R-HSA-8980692", "R-MMU-6809371", "R-CFA-1474228", "R-DRE-381426", "R-MMU-216083", "R-HSA-9013026", "R-DRE-351906", "R-HSA-198933", "R-HSA-9762292", "R-MMU-6798695", "R-CEL-6809371", "R-MMU-9696264", "R-HSA-9768727", "R-MMU-9768727", "R-MMU-9766229", "R-HSA-9768919", "R-DME-350379", "R-DRE-525793", "R-SSC-9696270", "R-SSC-6798695", "R-SSC-9696264", "R-HSA-6809371", "R-RNO-216083", "R-HSA-5626467", "R-DRE-1474228", "R-RNO-418990", "R-RNO-351906", "R-DME-350368", "R-CFA-216083", "R-HSA-9013423", "R-HSA-114608", "R-CFA-9768727", "R-DRE-9696264", "R-MMU-9764561", "R-RNO-8957275", "R-SSC-5218920", "R-HSA-9938206", "R-GGA-381426", "R-HSA-525793", "R-DME-450728", "R-HSA-6805567", "R-CFA-6809371", "R-DRE-8957275", "R-CEL-9013423", "R-CFA-9766229", "R-RNO-6809371", "R-RNO-9764561", "R-MMU-5626467", "R-HSA-216083", "R-HSA-9696270", "R-GGA-418990", "R-DME-6798695", "R-MMU-5218920", "R-HSA-9662361", "R-HSA-9927432", "R-DRE-6809371", "R-RNO-5626467", "R-DME-350480", "R-CFA-9764561", "R-HSA-9764302", "R-DME-351906", "R-MMU-418990", "R-HSA-8876493", "R-HSA-9830674", "R-SSC-6805567", "R-SSC-6809371", "R-RNO-9766229", "R-HSA-9856649", "R-MMU-525793", "R-HSA-8957275", "R-HSA-9856530", "R-HSA-9833576", "R-MMU-9696270", "R-MMU-6805567", "R-DME-9013423"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-RNO-525793:r:Myogenesis", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-418990:r:Adherens junctions interactions", "R-DME-390150:r:DS ligand bound to FT receptor", "R-HSA-9764561:r:Regulation of CDH1 Function", "R-DRE-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-8853659:r:RET signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9823730:r:Formation of definitive endoderm", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CFA-418990:r:Adherens junctions interactions", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-DRE-418990:r:Adherens junctions interactions", "R-RNO-6805567:r:Keratinization", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-DRE-9696270:r:RND2 GTPase cycle", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-390023:r:Subcellular localisation of D", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-418990:r:Adherens junctions interactions", "R-SSC-418990:r:Adherens junctions interactions", "R-DRE-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-8980692:r:RHOA GTPase cycle", "R-CFA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-8853659:r:RET signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-DRE-6805567:r:Keratinization", "R-DRE-9764561:r:Regulation of CDH1 Function", "R-DME-114608:r:Platelet degranulation", "R-MMU-8853659:r:RET signaling", "R-SSC-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-CFA-6805567:r:Keratinization", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-6809371:r:Formation of the cornified envelope", "R-GGA-525793:r:Myogenesis", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-9766229:r:Degradation of CDH1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-6809371:r:Formation of the cornified envelope", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-6809371:r:Formation of the cornified envelope", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-DRE-525793:r:Myogenesis", "R-SSC-9696270:r:RND2 GTPase cycle", "R-SSC-6798695:r:Neutrophil degranulation", "R-SSC-9696264:r:RND3 GTPase cycle", "R-HSA-6809371:r:Formation of the cornified envelope", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-RNO-418990:r:Adherens junctions interactions", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-CFA-216083:r:Integrin cell surface interactions", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-114608:r:Platelet degranulation", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-DRE-9696264:r:RND3 GTPase cycle", "R-MMU-9764561:r:Regulation of CDH1 Function", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-525793:r:Myogenesis", "R-DME-450728:r:Inhibition of actin polymerization", "R-HSA-6805567:r:Keratinization", "R-CFA-6809371:r:Formation of the cornified envelope", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-CFA-9766229:r:Degradation of CDH1", "R-RNO-6809371:r:Formation of the cornified envelope", "R-RNO-9764561:r:Regulation of CDH1 Function", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-GGA-418990:r:Adherens junctions interactions", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-DRE-6809371:r:Formation of the cornified envelope", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-CFA-9764561:r:Regulation of CDH1 Function", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-HSA-9830674:r:Formation of the ureteric bud", "R-SSC-6805567:r:Keratinization", "R-SSC-6809371:r:Formation of the cornified envelope", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-525793:r:Myogenesis", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9833576:r:CDH11 homotypic and heterotypic interactions", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-6805567:r:Keratinization", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR002128": {"description": "NADH:ubiquinone/plastoquinone oxidoreductase, chloroplast chain 5, C-terminal", "go_ids": [], "go_terms": [], "name": "NADH_UbQ_OxRdtase_chlpt_su5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002129": {"description": "Pyridoxal phosphate-dependent decarboxylase, major domain", "go_ids": ["GO:0019752", "GO:0030170", "GO:0016830"], "go_terms": ["GO:0019752:carboxylic acid metabolic process:P", "GO:0030170:pyridoxal phosphate binding:F", "GO:0016830:carbon-carbon lyase activity:F"], "name": "PyrdxlP-dep_de-COase", "pathway_ids": ["R-SCE-9845614", "R-MMU-888568", "R-RNO-9845614", "R-BTA-70921", "R-BTA-1614558", "R-HSA-1614558", "R-HSA-888568", "R-HSA-209905", "R-CFA-888568", "R-DME-888590", "R-HSA-209931", "R-RNO-209905", "R-XTR-8963693", "R-RNO-888568", "R-BTA-8963693", "R-MMU-209931", "R-SSC-888568", "R-HSA-70921", "R-RNO-888590", "R-RNO-70921", "R-DME-9845614", "R-CEL-9845614", "R-MMU-888590", "R-DME-209931", "R-MMU-209905", "R-HSA-8963693", "R-DME-209905", "R-SSC-888590", "R-BTA-888590", "R-XTR-1614558", "R-MMU-9845614", "R-DDI-9845614", "R-HSA-888590", "R-MMU-1614558", "R-HSA-9022927", "R-DME-70921", "R-HSA-9845614", "R-MMU-70921", "R-MMU-8963693", "R-RNO-209931", "R-BTA-888568", "R-DME-888568"], "pathways": ["R-SCE-9845614:r:Sphingolipid catabolism", "R-MMU-888568:r:GABA synthesis", "R-RNO-9845614:r:Sphingolipid catabolism", "R-BTA-70921:r:Histidine catabolism", "R-BTA-1614558:r:Degradation of cysteine and homocysteine", "R-HSA-1614558:r:Degradation of cysteine and homocysteine", "R-HSA-888568:r:GABA synthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-CFA-888568:r:GABA synthesis", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-RNO-209905:r:Catecholamine biosynthesis", "R-XTR-8963693:r:Aspartate and asparagine metabolism", "R-RNO-888568:r:GABA synthesis", "R-BTA-8963693:r:Aspartate and asparagine metabolism", "R-MMU-209931:r:Serotonin and melatonin biosynthesis", "R-SSC-888568:r:GABA synthesis", "R-HSA-70921:r:Histidine catabolism", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-70921:r:Histidine catabolism", "R-DME-9845614:r:Sphingolipid catabolism", "R-CEL-9845614:r:Sphingolipid catabolism", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-209905:r:Catecholamine biosynthesis", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-DME-209905:r:Catecholamine biosynthesis", "R-SSC-888590:r:GABA synthesis, release, reuptake and degradation", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-XTR-1614558:r:Degradation of cysteine and homocysteine", "R-MMU-9845614:r:Sphingolipid catabolism", "R-DDI-9845614:r:Sphingolipid catabolism", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-1614558:r:Degradation of cysteine and homocysteine", "R-HSA-9022927:r:MECP2 regulates transcription of genes involved in GABA signaling", "R-DME-70921:r:Histidine catabolism", "R-HSA-9845614:r:Sphingolipid catabolism", "R-MMU-70921:r:Histidine catabolism", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-BTA-888568:r:GABA synthesis", "R-DME-888568:r:GABA synthesis"], "type": "Domain"}, "IPR002130": {"description": "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain", "go_ids": ["GO:0003755", "GO:0000413"], "go_terms": ["GO:0003755:peptidyl-prolyl cis-trans isomerase activity:F", "GO:0000413:protein peptidyl-prolyl isomerization:P"], "name": "Cyclophilin-type_PPIase_dom", "pathway_ids": ["R-HSA-6798695", "R-HSA-180910", "R-BTA-8939211", "R-MMU-210991", "R-DME-6781823", "R-MMU-2467813", "R-CEL-6798695", "R-MMU-4570464", "R-DME-72163", "R-RNO-72163", "R-BTA-6798695", "R-DDI-6782210", "R-MMU-68877", "R-HSA-170822", "R-DDI-72163", "R-HSA-1650814", "R-HSA-164525", "R-HSA-6781823", "R-MMU-159230", "R-HSA-159230", "R-MMU-4551638", "R-CEL-8939211", "R-HSA-3371453", "R-HSA-8939211", "R-RNO-8939211", "R-HSA-4570464", "R-HSA-4551638", "R-HSA-210991", "R-DME-6782135", "R-HSA-173107", "R-BTA-72163", "R-HSA-9610379", "R-DDI-6798695", "R-MMU-8939211", "R-MMU-141444", "R-MMU-72163", "R-HSA-6784531", "R-MMU-3301854", "R-DDI-6781823", "R-HSA-141444", "R-HSA-8950505", "R-HSA-168325", "R-HSA-9648025", "R-CEL-6782210", "R-HSA-9609690", "R-HSA-162588", "R-HSA-162585", "R-MMU-170822", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-HSA-72163", "R-CEL-6781823", "R-MMU-159227", "R-HSA-5619107", "R-CEL-6782135", "R-MMU-6798695", "R-HSA-159236", "R-MMU-6782210", "R-MMU-3108214", "R-RNO-6798695", "R-MMU-5663220", "R-SCE-6782135", "R-DDI-6782135", "R-SPO-6798695", "R-HSA-9705671", "R-HSA-191859", "R-HSA-2467813", "R-HSA-3108214", "R-MMU-3232142", "R-MMU-6782135", "R-HSA-6781827", "R-SCE-6798695", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-HSA-168333", "R-HSA-2025928", "R-HSA-114608", "R-MMU-4085377", "R-HSA-162592", "R-MMU-6781823", "R-GGA-72163", "R-HSA-68877", "R-HSA-165054", "R-HSA-6782210", "R-HSA-175474", "R-CEL-72163", "R-HSA-4615885", "R-SCE-6782210", "R-HSA-9918481", "R-MMU-9648025", "R-MMU-191859", "R-MMU-159231", "R-BTA-1650814", "R-MMU-3371453", "R-MMU-2500257", "R-RNO-1650814", "R-HSA-2500257", "R-RNO-210991", "R-CEL-210991", "R-HSA-168276", "R-HSA-168271", "R-DME-6798695", "R-HSA-164516", "R-HSA-4085377", "R-HSA-6782135", "R-HSA-180689", "R-HSA-162594", "R-SCE-8939211", "R-MMU-1650814", "R-SPO-6782210", "R-HSA-9692916", "R-HSA-5663220", "R-DME-6782210", "R-HSA-180746", "R-SPO-6782135", "R-SPO-72163", "R-HSA-9725370"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-BTA-8939211:r:ESR-mediated signaling", "R-MMU-210991:r:Basigin interactions", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-72163:r:mRNA Splicing - 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synthesis and ligation in TC-NER", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-HSA-114608:r:Platelet degranulation", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-162592:r:Integration of provirus", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-210991:r:Basigin interactions", "R-CEL-210991:r:Basigin interactions", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-SCE-8939211:r:ESR-mediated signaling", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-180746:r:Nuclear import of Rev protein", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Domain"}, "IPR002132": {"description": "Large ribosomal subunit protein uL5", "go_ids": ["GO:0006412", "GO:0005840", "GO:0003735"], "go_terms": ["GO:0006412:translation:P", "GO:0005840:ribosome:C", "GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_uL5", "pathway_ids": ["R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-HSA-975957", "R-DME-9954714", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR002133": {"description": "S-adenosylmethionine synthetase", "go_ids": ["GO:0004478", "GO:0005524", "GO:0006556"], "go_terms": ["GO:0004478:methionine adenosyltransferase activity:F", "GO:0005524:ATP binding:F", "GO:0006556:S-adenosylmethionine biosynthetic process:P"], "name": "S-AdoMet_synthetase", "pathway_ids": ["PWY-5912", "PWY-6151", "PWY-5041", "R-CEL-156581", "R-RNO-1614635", "R-SCE-2408508", "R-DME-2408508", "R-DME-156581", "R-RNO-2408508", "R-SPO-2408508", "R-SCE-156581", "R-SCE-1614635", "R-CEL-2408508", "R-HSA-1614635", "R-HSA-2408508", "R-MMU-156581", "R-SPO-156581", "R-CEL-1614635", "R-SPO-1614635", "R-MMU-2408508", "R-DDI-1614635", "R-RNO-156581", "R-HSA-156581", "R-MMU-1614635", "R-DME-1614635", "R-HSA-5579024", "R-DDI-156581", "R-DDI-2408508"], "pathways": ["PWY-5912:t:2'-deoxymugineic acid phytosiderophore biosynthesis", "PWY-6151:t:S-adenosyl-L-methionine salvage I", "PWY-5041:t:S-adenosyl-L-methionine salvage II", "R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-SCE-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-DME-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-DME-156581:r:Methylation", "R-RNO-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-SPO-2408508:r:Metabolism of ingested SeMet, Sec, 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"R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR002137": {"description": "Beta-lactamase, class-D active site", "go_ids": ["GO:0008800", "GO:0017001"], "go_terms": ["GO:0008800:beta-lactamase activity:F", "GO:0017001:antibiotic catabolic process:P"], "name": "Beta-lactam_class-D_AS", "pathway_ids": ["R-HSA-9913143"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance"], "type": "Active_site"}, "IPR002140": {"description": "Ribosome maturation protein Sdo1/SBDS", "go_ids": ["GO:0042256"], "go_terms": ["GO:0042256:cytosolic ribosome assembly:P"], "name": "Sdo1/SBDS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002141": {"description": "Nucleoprotein, influenza virus", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Flu_NP", "pathway_ids": ["R-HSA-168255", "R-HSA-168271", "R-HSA-168288", 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independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR002145": {"description": "Ribbon-helix-helix protein, CopG", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "CopG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002146": {"description": "ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast", "go_ids": ["GO:0045259", "GO:0015078", "GO:0015986"], "go_terms": ["GO:0045259:proton-transporting ATP synthase complex:C", "GO:0015078:proton transmembrane transporter activity:F", "GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_b/b'su_bac/chlpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002148": {"description": "Rotavirus non-structural protein 1", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Rotavirus_NSP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002150": {"description": "Large ribosomal subunit protein bL31 type A/B", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bL31", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002151": {"description": "Kinesin light chain", "go_ids": ["GO:0005871"], "go_terms": ["GO:0005871:kinesin complex:C"], "name": "Kinesin_light", "pathway_ids": ["R-RNO-2132295", "R-RNO-5625970", "R-RNO-6811434", "R-HSA-2132295", "R-RNO-983189", "R-MMU-983189", "R-MMU-5625970", "R-CEL-983189", "R-DME-983189", "R-HSA-6811434", "R-HSA-983189", "R-MMU-2132295", "R-HSA-9725370", "R-HSA-5625970", "R-MMU-6811434"], "pathways": ["R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-5625970:r:RHO GTPases activate KTN1", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-983189:r:Kinesins", "R-MMU-983189:r:Kinesins", "R-MMU-5625970:r:RHO GTPases activate KTN1", "R-CEL-983189:r:Kinesins", "R-DME-983189:r:Kinesins", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-983189:r:Kinesins", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5625970:r:RHO GTPases activate KTN1", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR002152": {"description": "Glycoside hydrolase, family 23", "go_ids": ["GO:0003796", "GO:0009253"], "go_terms": ["GO:0003796:lysozyme activity:F", "GO:0009253:peptidoglycan catabolic process:P"], "name": "Glyco_hydro_23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002153": {"description": "Transient receptor potential channel, canonical", "go_ids": ["GO:0005262", "GO:0016020", "GO:0070588"], "go_terms": ["GO:0005262:calcium channel activity:F", "GO:0016020:membrane:C", "GO:0070588:calcium ion transmembrane transport:P"], "name": "TRPC_channel", "pathway_ids": ["R-MMU-114508", "R-DME-3295583", "R-BTA-114508", "R-HSA-139853", "R-MMU-139853", "R-HSA-983695", "R-DME-5578775", "R-RNO-5578775", "R-CEL-139853", "R-MMU-5578775", "R-DME-983695", "R-MMU-983695", "R-RNO-3295583", "R-HSA-114508", "R-CEL-3295583", "R-CEL-114508", "R-BTA-139853", "R-RNO-139853", "R-RNO-983695", "R-HSA-418890", "R-HSA-5578775", "R-HSA-9022699", "R-DRE-3295583", "R-RNO-114508", "R-BTA-3295583", "R-MMU-3295583", "R-HSA-3295583"], "pathways": ["R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-DME-3295583:r:TRP channels", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-CEL-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-5578775:r:Ion homeostasis", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-3295583:r:TRP channels", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-CEL-3295583:r:TRP channels", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-BTA-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-DRE-3295583:r:TRP channels", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-BTA-3295583:r:TRP channels", "R-MMU-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Family"}, "IPR002154": {"description": "Neuregulin, C-terminal", "go_ids": [], "go_terms": [], "name": "Neuregulin_C", "pathway_ids": ["R-MMU-1250342", "R-RNO-1306955", "R-MMU-6785631", "R-RNO-1250347", "R-GGA-1963642", "R-MMU-1306955", "R-MMU-6811558", "R-GGA-1227986", "R-HSA-1306955", "R-RNO-8863795", "R-GGA-1358803", "R-HSA-8863795", "R-RNO-6811558", "R-RNO-8847993", "R-RNO-1963642", "R-MMU-1236394", "R-HSA-9664565", "R-RNO-5673001", "R-MMU-5673001", "R-GGA-5673001", "R-HSA-9665686", "R-HSA-8847993", "R-HSA-2219530", "R-HSA-5673001", "R-HSA-6811558", "R-HSA-9620244", "R-RNO-1358803", "R-MMU-1963642", "R-MMU-1250196", "R-HSA-1257604", "R-GGA-1306955", "R-MMU-8863795", "R-RNO-6785631", "R-HSA-1251985", "R-RNO-1257604", "R-GGA-1963640", "R-HSA-1250342", "R-HSA-1250347", "R-GGA-6785631", "R-GGA-8863795", "R-MMU-8847993", "R-MMU-1250347", "R-HSA-1963642", "R-GGA-6811558", "R-HSA-1250196", "R-MMU-1358803", "R-GGA-1250196", "R-GGA-1257604", "R-HSA-1963640", "R-RNO-1963640", "R-RNO-1250342", "R-MMU-1227986", "R-RNO-1227986", "R-HSA-6785631", "R-HSA-1227986", "R-MMU-1257604", "R-HSA-1358803", "R-HSA-1236394", "R-GGA-1250347", "R-RNO-1236394", "R-RNO-1250196", "R-GGA-1236394", "R-GGA-1250342", "R-MMU-1963640"], "pathways": ["R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1963642:r:PI3K 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"R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9620244:r:Long-term potentiation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-GGA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-6785631:r:ERBB2 Regulates Cell Motility", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-GGA-1250196:r:SHC1 events in ERBB2 signaling", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-1227986:r:Signaling by ERBB2", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-1227986:r:Signaling by ERBB2", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-1236394:r:Signaling by ERBB4", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-1236394:r:Signaling by ERBB4", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-GGA-1236394:r:Signaling by ERBB4", "R-GGA-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling"], "type": "Domain"}, 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"R-HSA-77348", "R-CEL-77310", "R-MMU-9969896", "R-RNO-77108", "R-MMU-77348", "R-BTA-77285", "R-BTA-77305", "R-DRE-9837999", "R-RNO-9854311", "R-BTA-77350", "R-HSA-77310", "R-BTA-77346", "R-CEL-9854311", "R-HSA-390247", "R-MMU-77289", "R-MMU-390247", "R-MMU-6798695", "R-CEL-77285", "R-CEL-77108", "R-HSA-2046106", "R-RNO-6798695", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-CEL-77350", "R-BTA-77111", "R-SCE-2046106", "R-SCE-6798695", "R-RNO-77310", "R-DDI-70895", "R-DRE-9854311", "R-MMU-77111", "R-HSA-77350", "R-DDI-77111", "R-HSA-77285", "R-CEL-77305", "R-HSA-77111", "R-BTA-77108", "R-RNO-77350", "R-MMU-70895", "R-CEL-70895", "R-CEL-1482798", "R-MMU-77310", "R-RNO-77348", "R-HSA-9837999", "R-HSA-77305", "R-CEL-77111", "R-HSA-9969896", "R-DDI-9837999", "R-DDI-77108", "R-MMU-77108", "R-MMU-2046106", "R-BTA-9854311", "R-BTA-77310", "R-MMU-9033241", "R-RNO-9837999", "R-MMU-77285", "R-HSA-1482798", "R-BTA-77348", "R-RNO-70895", "R-MMU-77305", "R-HSA-9033500", "R-HSA-9033241", "R-HSA-77108", "R-RNO-390247", "R-RNO-9969896"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-6435:t:4-hydroxybenzoate biosynthesis III (plants)", "PWY-6443:t:benzoate biosynthesis I (CoA-dependent, beta-oxidative)", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-481:t:ethylbenzene degradation (anaerobic)", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-6458:t:benzoyl-CoA biosynthesis", "PWY-7948:t:4-oxopentanoate degradation", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-7094:t:fatty acid salvage", "PWY-8179:t:platensimycin biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-6080:t:4-ethylphenol degradation (anaerobic)", "R-RNO-1482798:r:Acyl chain remodeling of CL", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-77111:r:Synthesis of Ketone Bodies", "R-CEL-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9033241:r:Peroxisomal protein import", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-BTA-1482798:r:Acyl chain remodeling of CL", "R-DRE-70895:r:Branched-chain amino acid catabolism", "R-DRE-77108:r:Utilization of Ketone Bodies", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-9915355:r:Beta-ketothiolase deficiency", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-CEL-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-RNO-77108:r:Utilization of Ketone Bodies", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-CEL-77108:r:Utilization of Ketone Bodies", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-CEL-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-BTA-77111:r:Synthesis of Ketone Bodies", "R-SCE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DDI-77111:r:Synthesis of Ketone Bodies", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-CEL-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-BTA-77108:r:Utilization of Ketone Bodies", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-CEL-1482798:r:Acyl chain remodeling of CL", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-CEL-77111:r:Synthesis of Ketone Bodies", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DDI-77108:r:Utilization of Ketone Bodies", "R-MMU-77108:r:Utilization of Ketone Bodies", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-77108:r:Utilization of Ketone Bodies", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR002156": {"description": "Ribonuclease H domain", "go_ids": ["GO:0003676", "GO:0004523"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0004523:RNA-DNA hybrid ribonuclease activity:F"], "name": "RNaseH_domain", "pathway_ids": ["R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-9913635", "R-HSA-164843", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164525", "R-HSA-173107", "R-HSA-162594"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Domain"}, "IPR002157": {"description": "Cobalamin (vitamin B12)-binding protein", "go_ids": ["GO:0015889", "GO:0031419"], "go_terms": ["GO:0015889:cobalamin transport:P", "GO:0031419:cobalamin binding:F"], "name": "Cbl-bd_prot", "pathway_ids": ["R-HSA-6798695", "R-RNO-9758890", "R-RNO-9758881", "R-HSA-3359454", "R-MMU-9758890", "R-HSA-3359485", "R-HSA-3359463", "R-CFA-9758881", "R-DME-6798695", "R-HSA-3359462", "R-BTA-9758890", "R-DME-9758890", "R-HSA-9758881", "R-HSA-3359457", "R-MMU-9758881", "R-DME-9758881", "R-HSA-9758890"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9758890:r:Transport of RCbl within the body", "R-RNO-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-3359454:r:Defective TCN2 causes TCN2 deficiency", "R-MMU-9758890:r:Transport of RCbl within the body", "R-HSA-3359485:r:Defective CD320 causes MMATC", "R-HSA-3359463:r:Defective CUBN causes MGA1", "R-CFA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-3359462:r:Defective AMN causes MGA1", "R-BTA-9758890:r:Transport of RCbl within the body", "R-DME-9758890:r:Transport of RCbl within the body", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-3359457:r:Defective CBLIF causes IFD", "R-MMU-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DME-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-9758890:r:Transport of RCbl within the body"], "type": "Family"}, "IPR002159": {"description": "CD36 family", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "CD36_fam", "pathway_ids": ["R-RNO-1236973", "R-HSA-6798695", "R-MMU-8856828", "R-HSA-1989781", "R-HSA-168188", "R-HSA-8964011", "R-MMU-8856825", "R-HSA-8856828", "R-BTA-6798695", "R-DDI-114608", "R-RNO-3000471", "R-HSA-9841922", "R-RNO-114608", "R-DDI-8856825", "R-HSA-114608", "R-BTA-114608", "R-DME-1236973", "R-HSA-3000471", "R-RNO-434313", "R-RNO-8856828", "R-MMU-8964011", "R-HSA-5686938", "R-BTA-1236973", "R-BTA-3000471", "R-MMU-434313", "R-RNO-5686938", "R-DDI-6798695", "R-HSA-166058", "R-RNO-8856825", "R-MMU-3000471", "R-DME-6798695", "R-DME-114608", "R-HSA-381340", "R-HSA-1236973", "R-SSC-8964011", "R-HSA-6785807", "R-MMU-5686938", "R-RNO-8964011", "R-BTA-5686938", "R-MMU-1236973", "R-HSA-434313", "R-HSA-8856825", "R-BTA-434313", "R-DME-434313", "R-HSA-5603041", "R-HSA-5602498", "R-HSA-1236974", "R-MMU-6798695", "R-DDI-434313", "R-SSC-3000471", "R-BTA-8964011", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-RNO-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-168188:r:Toll Like Receptor TLR6:TLR2 Cascade", "R-HSA-8964011:r:HDL clearance", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-114608:r:Platelet degranulation", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-114608:r:Platelet degranulation", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8964011:r:HDL clearance", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-BTA-3000471:r:Scavenging by Class B Receptors", "R-MMU-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-114608:r:Platelet degranulation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-SSC-8964011:r:HDL clearance", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964011:r:HDL clearance", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-DME-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-SSC-3000471:r:Scavenging by Class B Receptors", "R-BTA-8964011:r:HDL clearance", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR002160": {"description": "Proteinase inhibitor I3, Kunitz legume", "go_ids": ["GO:0004866"], "go_terms": ["GO:0004866:endopeptidase inhibitor activity:F"], "name": "Prot_inh_Kunz-lg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002161": {"description": "Pyridoxal 5'-phosphate synthase subunit PdxT/SNO", "go_ids": ["GO:0042823", "GO:0004359", "GO:0042819"], "go_terms": ["GO:0042823:pyridoxal 5'-phosphate biosynthetic process:P", "GO:0004359:glutaminase activity:F", "GO:0042819:vitamin B6 biosynthetic process:P"], "name": "PdxT/SNO", "pathway_ids": ["PWY-6466", "PWY-5921"], "pathways": ["PWY-6466:t:pyridoxal 5'-phosphate biosynthesis II", "PWY-5921:t:glutaminyl-tRNAgln biosynthesis via transamidation"], "type": "Family"}, "IPR002164": {"description": "Nucleosome assembly protein", "go_ids": ["GO:0005634", "GO:0006334"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006334:nucleosome assembly:P"], "name": "NAP", "pathway_ids": ["R-MMU-2299718", "R-RNO-2299718", "R-HSA-450520", "R-HSA-2299718", "R-RNO-450520", "R-HSA-381038", "R-MMU-450520", "R-DME-450520"], "pathways": ["R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA"], "type": "Family"}, "IPR002165": {"description": "Plexin repeat", "go_ids": [], "go_terms": [], "name": "Plexin_repeat", "pathway_ids": ["R-HSA-9013405", "R-HSA-8874081", "R-HSA-8875555", "R-DRE-399954", "R-MMU-6811558", "R-MMU-8875791", "R-CEL-416482", "R-RNO-416550", "R-MMU-416572", "R-MMU-8865999", "R-SSC-6811558", "R-HSA-6806942", "R-RNO-399954", "R-MMU-8851805", "R-RNO-6811558", "R-MMU-399954", "R-HSA-399955", "R-HSA-8875513", "R-DRE-416550", "R-HSA-9825892", "R-RNO-8865999", "R-MMU-5673001", "R-RNO-5673001", "R-RNO-6806942", "R-DRE-416572", "R-MMU-399955", "R-HSA-416482", "R-HSA-2219530", "R-SSC-416550", "R-HSA-9696264", "R-HSA-5673001", "R-HSA-6811558", "R-MMU-8875555", "R-RNO-5173214", "R-RNO-8875656", "R-DME-416572", "R-RNO-8851805", "R-HSA-399954", "R-DRE-399956", "R-MMU-5173214", "R-DME-416482", "R-RNO-9696264", "R-MMU-8875513", "R-DME-416700", "R-SSC-6806942", "R-RNO-8875555", "R-MMU-9696264", "R-HSA-1257604", "R-SSC-9734091", "R-MMU-416700", "R-MMU-399956", "R-HSA-8865999", "R-MMU-416550", "R-RNO-8851907", "R-SSC-1257604", "R-SSC-8875513", "R-HSA-416550", "R-HSA-399956", "R-HSA-416572", "R-RNO-1257604", "R-CEL-416700", "R-RNO-9734091", "R-RNO-8874081", "R-RNO-8875513", "R-MMU-8874081", "R-CEL-399955", "R-HSA-416700", "R-HSA-8851907", "R-SSC-8874081", "R-HSA-9615017", "R-CEL-399956", "R-HSA-8851805", "R-SSC-8851907", "R-MMU-9734091", "R-HSA-9734091", "R-RNO-399956", "R-HSA-8875791", "R-HSA-8852405", "R-SSC-6807004", "R-HSA-9013508", "R-HSA-9696270", "R-RNO-416700", "R-RNO-8875791", "R-HSA-5083635", "R-SSC-8875555", "R-MMU-1257604", "R-HSA-6807004", "R-CEL-416572", "R-RNO-6807004", "R-SSC-5673001", "R-MMU-6806942", "R-RNO-399955", "R-HSA-5173214", "R-MMU-8851907", "R-MMU-8875656", "R-MMU-416482", "R-SSC-8875791", "R-HSA-9022699", "R-MMU-6807004", "R-SSC-8865999", "R-HSA-8875656", "R-SSC-8851805", "R-DME-5173214", "R-MMU-9696273", "R-MMU-9696270", "R-SSC-8875656", "R-HSA-8875360", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8875791:r:MET activates STAT3", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-8865999:r:MET activates PTPN11", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-DRE-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-RNO-8865999:r:MET activates PTPN11", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-6806942:r:MET Receptor Activation", "R-DRE-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-8875656:r:MET receptor recycling", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-8851805:r:MET activates RAS signaling", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-DME-416482:r:G alpha (12/13) signalling events", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-DME-416700:r:Other semaphorin interactions", "R-SSC-6806942:r:MET Receptor Activation", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-416700:r:Other semaphorin interactions", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-SSC-8874081:r:MET activates PTK2 signaling", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-HSA-8851805:r:MET activates RAS signaling", "R-SSC-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-8852405:r:Signaling by MST1", "R-SSC-6807004:r:Negative regulation of MET activity", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-416700:r:Other semaphorin interactions", "R-RNO-8875791:r:MET activates STAT3", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-SSC-8875555:r:MET activates RAP1 and RAC1", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-6807004:r:Negative regulation of MET activity", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-6806942:r:MET Receptor Activation", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-SSC-8875791:r:MET activates STAT3", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-MMU-6807004:r:Negative regulation of MET activity", "R-SSC-8865999:r:MET activates PTPN11", "R-HSA-8875656:r:MET receptor recycling", "R-SSC-8851805:r:MET activates RAS signaling", "R-DME-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SSC-8875656:r:MET receptor recycling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Repeat"}, "IPR002166": {"description": "RNA dependent RNA polymerase, hepatitis C virus", "go_ids": ["GO:0003723", "GO:0003968", "GO:0039694"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0039694:viral RNA genome replication:P"], "name": "RNA_pol_HCV", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Family"}, "IPR002169": {"description": "Peptidase M9A/M9B, collagenase, bacterial", "go_ids": ["GO:0005576", "GO:0006508", "GO:0008270", "GO:0004222"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006508:proteolysis:P", "GO:0008270:zinc ion binding:F", "GO:0004222:metalloendopeptidase activity:F"], "name": "Peptidase_M9A/M9B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002171": {"description": "Large ribosomal subunit protein uL2", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": 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"R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR002172": {"description": "Low-density lipoprotein (LDL) receptor class A repeat", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "LDrepeatLR_classA_rpt", "pathway_ids": ["R-MMU-8856828", "R-BTA-8964026", "R-MMU-8964046", "R-MMU-4641263", "R-HSA-9700645", "R-HSA-3000178", "R-HSA-8856828", "R-HSA-3560783", "R-RNO-8866376", "R-HSA-9918485", "R-HSA-2168880", "R-HSA-432142", "R-CEL-1566948", "R-RNO-8964026", "R-HSA-9856532", "R-HSA-3656237", "R-GGA-8866376", "R-RNO-8964038", 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"R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-210993:r:Tie2 Signaling", "R-BTA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-9762292:r:Regulation of CDH11 function", "R-SSC-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-114608:r:Platelet degranulation", "R-SSC-9762292:r:Regulation of CDH11 function", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-977225:r:Amyloid fiber formation", "R-CFA-210993:r:Tie2 Signaling", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-RNO-9762292:r:Regulation of CDH11 function", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-114608:r:Platelet degranulation", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-RNO-354192:r:Integrin signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-6803157:r:Antimicrobial peptides", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-HSA-354192:r:Integrin signaling", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-166662:r:Lectin pathway of complement activation", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR002182": {"description": "NB-ARC", "go_ids": ["GO:0043531"], "go_terms": ["GO:0043531:ADP binding:F"], "name": "NB-ARC", "pathway_ids": ["R-HSA-111459", "R-HSA-6798695", "R-DRE-111459", "R-DME-9627069", "R-HSA-6803207", "R-DME-6798695", "R-HSA-111464", "R-HSA-111458", "R-MMU-111458", "R-DRE-111458", "R-RNO-111459", "R-HSA-8953750", "R-DRE-9627069", "R-MMU-111459", "R-RNO-111458", "R-MMU-9627069", "R-DME-111458", "R-DRE-6798695", "R-RNO-9627069", "R-MMU-6798695", "R-DME-111459", "R-HSA-9627069", "R-HSA-111463", "R-RNO-6798695"], "pathways": ["R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-111458:r:Formation of apoptosome", "R-MMU-111458:r:Formation of apoptosome", "R-DRE-111458:r:Formation of apoptosome", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-111458:r:Formation of apoptosome", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DME-111458:r:Formation of apoptosome", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR002183": {"description": "Interleukin-3", "go_ids": ["GO:0005135", "GO:0005576", "GO:0006955", "GO:0008083"], "go_terms": ["GO:0005135:interleukin-3 receptor binding:F", "GO:0005576:extracellular region:C", "GO:0006955:immune response:P", "GO:0008083:growth factor activity:F"], "name": "IL-3", "pathway_ids": ["R-MMU-912526", "R-HSA-8939247", "R-CFA-512988", "R-CFA-912526", "R-BTA-912526", "R-HSA-912526", "R-BTA-5673001", "R-CFA-5673001", "R-MMU-512988", "R-MMU-5673001", "R-HSA-512988", "R-RNO-5673001", "R-RNO-512988", "R-BTA-512988", "R-RNO-912526", "R-HSA-5673001"], "pathways": ["R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-CFA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CFA-912526:r:Interleukin receptor SHC signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Family"}, "IPR002184": {"description": "7TM GPCR, serpentine receptor class b (Srb)", "go_ids": ["GO:0004888", "GO:0007606", "GO:0016020"], "go_terms": ["GO:0004888:transmembrane signaling receptor activity:F", "GO:0007606:sensory perception of chemical stimulus:P", "GO:0016020:membrane:C"], "name": "7TM_GPCR_serpentine_rcpt_Srb", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002186": {"description": "Neocarzinostatin-like", "go_ids": ["GO:0003677", "GO:0006952"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006952:defense response:P"], "name": "Neocarzinostatin_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002187": {"description": "Nitrogen regulatory protein PII", "go_ids": ["GO:0006808", "GO:0030234"], "go_terms": ["GO:0006808:regulation of nitrogen utilization:P", "GO:0030234:enzyme regulator activity:F"], "name": "N-reg_PII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002189": {"description": "F-actin-capping protein subunit alpha", "go_ids": ["GO:0008290", "GO:0051016"], "go_terms": ["GO:0008290:F-actin capping protein complex:C", "GO:0051016:barbed-end actin filament capping:P"], "name": "CapZ_alpha", "pathway_ids": ["R-HSA-2132295", "R-HSA-879415", "R-RNO-879415", "R-GGA-879415", "R-HSA-9662360", "R-BTA-879415", "R-HSA-983231", "R-HSA-6807878", "R-MMU-879415", "R-HSA-8950505", "R-HSA-3371497", "R-HSA-6811436", "R-SSC-879415"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-GGA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling"], "type": "Family"}, "IPR002190": {"description": "MAGE homology domain", "go_ids": [], "go_terms": [], "name": "MHD_dom", "pathway_ids": ["R-SCE-3108214", "R-HSA-114608", "R-HSA-193648", "R-SPO-3108214", "R-RNO-9768919", "R-HSA-3108214", "R-MMU-9768919", "R-HSA-418889", "R-SCE-114608", "R-MMU-3108214", "R-HSA-6785807", "R-SPO-114608", "R-HSA-9768919"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-SCE-114608:r:Platelet degranulation", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SPO-114608:r:Platelet degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Domain"}, "IPR002191": {"description": "Bacterial export protein family 3", "go_ids": ["GO:0009306", "GO:0016020"], "go_terms": ["GO:0009306:protein secretion:P", "GO:0016020:membrane:C"], "name": "Bac_export_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002192": {"description": "Pyruvate phosphate dikinase, AMP/ATP-binding", "go_ids": ["GO:0005524", "GO:0016301", "GO:0016310"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016301:kinase activity:F", "GO:0016310:phosphorylation:P"], "name": "PPDK_AMP/ATP-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002196": {"description": "Glycoside hydrolase, family 24", "go_ids": ["GO:0003796", "GO:0009253", "GO:0016998"], "go_terms": ["GO:0003796:lysozyme activity:F", "GO:0009253:peptidoglycan catabolic process:P", "GO:0016998:cell wall macromolecule catabolic process:P"], "name": "Glyco_hydro_24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002197": {"description": "DNA binding HTH domain, Fis-type", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "HTH_Fis", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002200": {"description": "Elicitin", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Elicitin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002201": {"description": "Glycosyl transferase, family 9", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "Glyco_trans_9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002202": {"description": "Hydroxymethylglutaryl-CoA reductase, class I/II", "go_ids": ["GO:0004420", "GO:0015936"], "go_terms": ["GO:0004420:hydroxymethylglutaryl-CoA reductase (NADPH) activity:F", "GO:0015936:coenzyme A metabolic process:P"], "name": "HMG_CoA_Rdtase", "pathway_ids": ["PWY-7524", "PWY-7391", "PWY-922", "PWY-8125", "PWY-6174", "R-SCE-9969896", "R-HSA-1989781", "R-DME-9969896", "R-RNO-9969896", "R-BTA-9969896", "R-HSA-9619665", "R-DDI-9969896", "R-MMU-9969896", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["PWY-7524:t:mevalonate pathway III (Thermoplasma)", "PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "PWY-8125:t:mevalonate pathway IV (archaea)", "PWY-6174:t:mevalonate pathway II (haloarchaea)", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9969896:r:Lanosterol biosynthesis", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR002205": {"description": "DNA topoisomerase, type IIA, domain A", "go_ids": ["GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F", "GO:0005524:ATP binding:F", "GO:0006265:DNA topological change:P"], "name": "Topo_IIA_dom_A", "pathway_ids": ["R-HSA-9913143", "R-RNO-4615885", "R-HSA-9638771", "R-SCE-4615885", "R-SPO-4615885", "R-HSA-1362277", "R-DME-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9638771:r:Action of antimicrobials", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA 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"R-SPO-9013106", "R-RNO-392517", "R-MMU-9013422", "R-DME-111465", "R-RNO-2029485", "R-SCE-5607764", "R-RNO-2179392", "R-HSA-9649948", "R-CEL-114508", "R-CEL-1433559", "R-BTA-2871809", "R-MMU-5668599", "R-RNO-9013424", "R-RNO-202424", "R-XTR-1169092", "R-BTA-392517", "R-RNO-9013406", "R-XTR-392517", "R-CEL-264642", "R-CEL-9013148", "R-SCE-9856530", "R-MMU-9748787", "R-MMU-420029", "R-SPO-5607764", "R-DME-8980692", "R-HSA-2514859", "R-RNO-8853659", "R-MMU-8853659", "R-HSA-9755511", "R-CEL-76005", "R-HSA-2219530", "R-MMU-450520", "R-BTA-912631", "R-MMU-445144", "R-DME-2173791", "R-GGA-5621575", "R-RNO-420029", "R-CEL-202424", "R-DME-9755511", "R-MMU-111933", "R-HSA-9013404", "R-MMU-264642", "R-DME-399997", "R-HSA-9013149", "R-MMU-9634635", "R-HSA-1169091", "R-HSA-8980692", "R-DME-445144", "R-MMU-2871837", "R-RNO-264642", "R-SPO-9013424", "R-BTA-114604", "R-RNO-4419969", "R-RNO-181429", "R-SPO-2179392", "R-RNO-4420097", "R-HSA-114516", "R-MMU-1169092", "R-DME-1169091", "R-RNO-430116"], "pathways": ["R-SPO-1489509:r:DAG and IP3 signaling", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-RNO-111933:r:Calmodulin induced events", "R-BTA-114516:r:Disinhibition of SNARE formation", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-SCE-1169091:r:Activation of NF-kappaB in B cells", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-2672351:r:Stimuli-sensing channels", "R-SCE-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-DME-2424491:r:DAP12 signaling", "R-DRE-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-373752:r:Netrin-1 signaling", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-9648002:r:RAS processing", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-1489509:r:DAG and IP3 signaling", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-354192:r:Integrin signaling", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-193648:r:NRAGE signals death through JNK", "R-CEL-392517:r:Rap1 signalling", "R-RNO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-877300:r:Interferon gamma signaling", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-BTA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-MMU-2424491:r:DAP12 signaling", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-XTR-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-GGA-9732724:r:IFNG signaling activates MAPKs", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-420029:r:Tight junction interactions", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-CEL-9013407:r:RHOH GTPase cycle", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-8980692:r:RHOA GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-170968:r:Frs2-mediated activation", "R-MMU-392517:r:Rap1 signalling", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-5673000:r:RAF activation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-373752:r:Netrin-1 signaling", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-SCE-1489509:r:DAG and IP3 signaling", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-354192:r:Integrin signaling", "R-GGA-5673000:r:RAF activation", "R-HSA-392517:r:Rap1 signalling", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-SSC-114508:r:Effects of PIP2 hydrolysis", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-111933:r:Calmodulin induced events", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-1489509:r:DAG and IP3 signaling", "R-SCE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-CEL-9748787:r:Azathioprine ADME", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-354192:r:Integrin signaling", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-SPO-399997:r:Acetylcholine regulates insulin secretion", "R-DDI-5689880:r:Ub-specific processing proteases", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-DRE-420029:r:Tight junction interactions", "R-HSA-3000170:r:Syndecan interactions", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-DRE-9013424:r:RHOV GTPase cycle", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-6798695:r:Neutrophil degranulation", "R-GGA-392517:r:Rap1 signalling", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-CEL-2672351:r:Stimuli-sensing channels", "R-SPO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-CEL-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-170968:r:Frs2-mediated activation", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-877300:r:Interferon gamma signaling", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1433559:r:Regulation of KIT signaling", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-912631:r:Regulation of signaling by CBL", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-202424:r:Downstream TCR signaling", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DDI-170968:r:Frs2-mediated activation", "R-CEL-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-2871837:r:FCERI mediated NF-kB activation", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DRE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DRE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-9748787:r:Azathioprine ADME", "R-DME-5673000:r:RAF activation", "R-DME-5674135:r:MAP2K and MAPK activation", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-CEL-1912408:r:Pre-NOTCH Transcription and Translation", "R-DRE-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-XTR-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-GGA-430116:r:GP1b-IX-V activation signalling", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CEL-5674499:r:Negative feedback regulation of MAPK pathway", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-354192:r:Integrin signaling", "R-DME-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SCE-2871837:r:FCERI mediated NF-kB activation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-114516:r:Disinhibition of SNARE formation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-9648002:r:RAS processing", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-430116:r:GP1b-IX-V activation signalling", "R-XTR-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-1169092:r:Activation of RAS in B cells", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DME-9748787:r:Azathioprine ADME", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-5674499:r:Negative feedback regulation of MAPK pathway", "R-DME-209190:r:Phosphorylation of CI", "R-DME-170968:r:Frs2-mediated activation", "R-DDI-3295583:r:TRP channels", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-CEL-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-CEL-445144:r:Signal transduction by L1", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DRE-4419969:r:Depolymerization of the Nuclear Lamina", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-SPO-9035034:r:RHOF GTPase cycle", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-1169092:r:Activation of RAS in B cells", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-DME-3000170:r:Syndecan interactions", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-GGA-2672351:r:Stimuli-sensing channels", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-114508:r:Effects of PIP2 hydrolysis", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-DME-114516:r:Disinhibition of SNARE formation", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-983189:r:Kinesins", "R-CEL-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-202424:r:Downstream TCR signaling", "R-SCE-202424:r:Downstream TCR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-XTR-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SSC-5673000:r:RAF activation", "R-SCE-399997:r:Acetylcholine regulates insulin secretion", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-9013408:r:RHOG GTPase cycle", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-HSA-1489509:r:DAG and IP3 signaling", "R-CEL-5673000:r:RAF activation", "R-RNO-1433559:r:Regulation of KIT signaling", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-3000170:r:Syndecan interactions", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5673000:r:RAF activation", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-XTR-114516:r:Disinhibition of SNARE formation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-DME-9013148:r:CDC42 GTPase cycle", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-5673000:r:RAF activation", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1489509:r:DAG and IP3 signaling", "R-DDI-445144:r:Signal transduction by L1", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SPO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-5673000:r:RAF activation", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-HSA-2424491:r:DAP12 signaling", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-CEL-9648002:r:RAS processing", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-DME-9648002:r:RAS processing", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-MMU-1912408:r:Pre-NOTCH Transcription and Translation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-HSA-418597:r:G alpha (z) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-111933:r:Calmodulin induced events", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-HSA-445144:r:Signal transduction by L1", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DME-416482:r:G alpha (12/13) signalling events", "R-CEL-170968:r:Frs2-mediated activation", "R-HSA-9648002:r:RAS processing", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-DME-373752:r:Netrin-1 signaling", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-SCE-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-1489509:r:DAG and IP3 signaling", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-983189:r:Kinesins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-DRE-1912408:r:Pre-NOTCH Transcription and Translation", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-392517:r:Rap1 signalling", "R-CEL-111933:r:Calmodulin induced events", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-CEL-373752:r:Netrin-1 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-4086398:r:Ca2+ pathway", "R-RNO-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-MMU-202424:r:Downstream TCR signaling", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-193648:r:NRAGE signals death through JNK", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-114516:r:Disinhibition of SNARE formation", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-912631:r:Regulation of signaling by CBL", "R-SPO-114508:r:Effects of PIP2 hydrolysis", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DDI-392517:r:Rap1 signalling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-SPO-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-SCE-9013106:r:RHOC GTPase cycle", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-XTR-354192:r:Integrin signaling", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-5674499:r:Negative feedback regulation of MAPK pathway", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-CEL-912631:r:Regulation of signaling by CBL", "R-DME-114604:r:GPVI-mediated activation cascade", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-SPO-9013106:r:RHOC GTPase cycle", "R-RNO-392517:r:Rap1 signalling", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-CEL-1433559:r:Regulation of KIT signaling", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-9013424:r:RHOV GTPase cycle", "R-RNO-202424:r:Downstream TCR signaling", "R-XTR-1169092:r:Activation of RAS in B cells", "R-BTA-392517:r:Rap1 signalling", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-XTR-392517:r:Rap1 signalling", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9748787:r:Azathioprine ADME", "R-MMU-420029:r:Tight junction interactions", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-BTA-912631:r:Regulation of signaling by CBL", "R-MMU-445144:r:Signal transduction by L1", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-420029:r:Tight junction interactions", "R-CEL-202424:r:Downstream TCR signaling", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-111933:r:Calmodulin induced events", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DME-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SPO-9013424:r:RHOV GTPase cycle", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-MMU-1169092:r:Activation of RAS in B cells", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-430116:r:GP1b-IX-V activation signalling"], "type": "Domain"}, "IPR002220": {"description": "DapA-like", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "DapA-like", "pathway_ids": ["PWY-5097", "PWY-2942", "PWY-8088", "PWY-2941", "R-BTA-389661", "R-SSC-4085001", "R-MMU-4085001", "R-RNO-4085001", "R-MMU-389661", "R-BTA-4085001", "R-HSA-4085001", "R-DRE-389661", "R-XTR-4085001", "R-HSA-389661", "R-DRE-4085001"], "pathways": ["PWY-5097:t:L-lysine biosynthesis VI", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8088:t:dipicolinate biosynthesis", "PWY-2941:t:L-lysine biosynthesis II", "R-BTA-389661:r:Glyoxylate metabolism and glycine degradation", "R-SSC-4085001:r:Sialic acid metabolism", "R-MMU-4085001:r:Sialic acid metabolism", "R-RNO-4085001:r:Sialic acid metabolism", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-BTA-4085001:r:Sialic acid metabolism", "R-HSA-4085001:r:Sialic acid metabolism", "R-DRE-389661:r:Glyoxylate metabolism and glycine degradation", "R-XTR-4085001:r:Sialic acid metabolism", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-DRE-4085001:r:Sialic acid metabolism"], "type": "Family"}, "IPR002222": {"description": "Small ribosomal subunit protein uS19", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uS19", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-RNO-1799339", "R-RNO-72695", "R-HSA-72695", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-CEL-72706", "R-BTA-72695", "R-GGA-72706", "R-CEL-9954716", "R-CEL-9954714", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-DDI-72695", "R-CEL-1799339", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-GGA-9954716", "R-CEL-156827", "R-RNO-6791226", "R-RNO-72649", "R-GGA-72649", "R-HSA-6791226", "R-RNO-975956", "R-CEL-72649", "R-SPO-156827", "R-HSA-9954714", "R-BTA-72649", "R-GGA-72695", "R-SPO-72689", "R-GGA-72702", "R-MMU-1799339", "R-GGA-975956", "R-DDI-72702", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DDI-72689", "R-CEL-72689", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DDI-9954716", "R-SPO-1799339", "R-GGA-9954714", "R-SCE-1799339", "R-SCE-72689", "R-MMU-72695", "R-MMU-975956", "R-SCE-72695", "R-SCE-156827", "R-MMU-72702", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-HSA-9754678", "R-HSA-72649", "R-MMU-156827", "R-SCE-9954714", "R-BTA-1799339", "R-BTA-9954714", "R-GGA-975957", "R-HSA-975957", "R-SCE-72649", "R-BTA-975956", "R-DDI-72706", "R-GGA-1799339", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-72649:r:Translation initiation complex formation", "R-GGA-72649:r:Translation initiation complex formation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72649:r:Translation initiation complex formation", "R-GGA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-72649:r:Translation initiation complex formation", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR002223": {"description": "Pancreatic trypsin inhibitor Kunitz domain", "go_ids": ["GO:0004867"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F"], "name": "Kunitz_BPTI", "pathway_ids": ["R-HSA-186797", "R-MMU-416476", "R-SSC-432720", "R-MMU-204005", "R-HSA-879415", "R-HSA-3000178", "R-MMU-5694530", "R-HSA-2168880", "R-RNO-444473", "R-MMU-933542", "R-MMU-8957275", "R-HSA-5694530", "R-HSA-1650814", "R-MMU-2214320", "R-HSA-6806942", "R-MMU-445989", "R-MMU-3000178", "R-MMU-381426", "R-HSA-6803157", "R-HSA-8948216", "R-HSA-9609523", "R-SSC-445989", "R-RNO-416476", "R-RNO-3000178", "R-MMU-2168880", "R-HSA-381426", "R-SSC-3000178", "R-SSC-381426", "R-RNO-6803157", "R-RNO-432720", "R-HSA-432720", "R-RNO-2168880", "R-HSA-9660826", "R-SSC-9609523", "R-HSA-419037", "R-RNO-381426", "R-HSA-204005", "R-HSA-2022090", "R-RNO-879415", "R-RNO-445989", "R-MMU-216083", "R-HSA-140834", "R-RNO-933542", "R-MMU-114608", "R-HSA-844456", "R-HSA-445989", "R-MMU-9837999", "R-MMU-444473", "R-HSA-3000157", "R-MMU-8948216", "R-HSA-933542", "R-HSA-977225", "R-MMU-140834", "R-SSC-114608", "R-HSA-8862803", "R-HSA-416476", "R-RNO-9609523", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-MMU-8852405", "R-RNO-8957275", "R-SSC-933542", "R-RNO-140834", "R-HSA-444473", "R-HSA-9837999", "R-MMU-432720", "R-MMU-9609523", "R-MMU-6803157", "R-HSA-1442490", "R-HSA-9925563", "R-HSA-2214320", "R-HSA-8852405", "R-HSA-216083", "R-MMU-1566977", "R-SSC-8957275", "R-HSA-1566977", "R-MMU-879415", "R-RNO-9837999", "R-SSC-879415", "R-HSA-418594", "R-MMU-6806942", "R-MMU-1650814", "R-SSC-9837999", "R-HSA-8957275", "R-MMU-1442490"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2214320:r:Anchoring fibril formation", "R-HSA-6806942:r:MET Receptor Activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-3000178:r:ECM proteoglycans", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-HSA-8948216:r:Collagen chain trimerization", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6803157:r:Antimicrobial peptides", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-SSC-114608:r:Platelet degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8852405:r:Signaling by MST1", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-1442490:r:Collagen degradation", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8852405:r:Signaling by MST1", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-HSA-1566977:r:Fibronectin matrix formation", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-6806942:r:MET Receptor Activation", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1442490:r:Collagen degradation"], "type": "Domain"}, "IPR002225": {"description": "3-beta hydroxysteroid dehydrogenase/isomerase", "go_ids": ["GO:0006694", "GO:0016616"], "go_terms": ["GO:0006694:steroid biosynthetic process:P", "GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "3Beta_OHSteriod_DH/Estase", "pathway_ids": ["R-RNO-193807", "R-CFA-193048", "R-SPO-6807047", "R-BTA-6807062", "R-MMU-193775", "R-SSC-193993", "R-RNO-193993", "R-HSA-193368", "R-RNO-193048", "R-HSA-6807047", "R-MMU-6807047", "R-HSA-193993", "R-MMU-194002", "R-HSA-193048", "R-MMU-193048", "R-SPO-6807062", "R-BTA-193993", "R-MMU-6807062", "R-CFA-194002", "R-SSC-194002", "R-SCE-6807062", "R-HSA-193775", "R-MMU-193368", "R-BTA-194002", "R-RNO-6807062", "R-RNO-194002", "R-HSA-6807062", "R-HSA-193807", "R-MMU-193993", "R-BTA-193048", "R-BTA-6807047", "R-SSC-193048", "R-RNO-193775", "R-CFA-193993", "R-RNO-193368", "R-SCE-6807047", "R-RNO-6807047", "R-MMU-193807", "R-HSA-194002"], "pathways": ["R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-CFA-193048:r:Androgen biosynthesis", "R-SPO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-BTA-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-MMU-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-SSC-193993:r:Mineralocorticoid biosynthesis", "R-RNO-193993:r:Mineralocorticoid biosynthesis", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-193048:r:Androgen biosynthesis", "R-HSA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-HSA-193993:r:Mineralocorticoid biosynthesis", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-HSA-193048:r:Androgen biosynthesis", "R-MMU-193048:r:Androgen biosynthesis", "R-SPO-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-BTA-193993:r:Mineralocorticoid biosynthesis", "R-MMU-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-CFA-194002:r:Glucocorticoid biosynthesis", "R-SSC-194002:r:Glucocorticoid biosynthesis", "R-SCE-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-194002:r:Glucocorticoid biosynthesis", "R-RNO-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-RNO-194002:r:Glucocorticoid biosynthesis", "R-HSA-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-MMU-193993:r:Mineralocorticoid biosynthesis", "R-BTA-193048:r:Androgen biosynthesis", "R-BTA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-SSC-193048:r:Androgen biosynthesis", "R-RNO-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-CFA-193993:r:Mineralocorticoid biosynthesis", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SCE-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-194002:r:Glucocorticoid biosynthesis"], "type": "Domain"}, "IPR002227": {"description": "Tyrosinase copper-binding domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Tyrosinase_Cu-bd", "pathway_ids": ["R-SSC-5662702", "R-HSA-9824585", "R-HSA-5662702", "R-CEL-5662702", "R-MMU-5662702"], "pathways": ["R-SSC-5662702:r:Melanin biosynthesis", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-5662702:r:Melanin biosynthesis", "R-CEL-5662702:r:Melanin biosynthesis", "R-MMU-5662702:r:Melanin biosynthesis"], "type": "Domain"}, "IPR002241": {"description": "Glycoside hydrolase, family 27", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_27", "pathway_ids": ["PWY-6527", "R-MMU-6798695", "R-HSA-6798695", "R-MMU-9840310", "R-HSA-9840310"], "pathways": ["PWY-6527:t:stachyose degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Family"}, "IPR002252": {"description": "Glycoside hydrolase family 36", "go_ids": ["GO:0004557", "GO:0016052"], "go_terms": ["GO:0004557:alpha-galactosidase activity:F", "GO:0016052:carbohydrate catabolic process:P"], "name": "Glyco_hydro_36", "pathway_ids": ["PWY-6527"], "pathways": ["PWY-6527:t:stachyose degradation"], "type": "Family"}, "IPR002259": {"description": "Equilibrative nucleoside transporter", "go_ids": ["GO:0005337", "GO:1901642", "GO:0016020"], "go_terms": ["GO:0005337:nucleoside transmembrane 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bases across the plasma membrane", "R-MMU-9755088:r:Ribavirin ADME", "R-PFA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-5619063:r:Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)", "R-HSA-9748787:r:Azathioprine ADME", "R-SCE-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-9755088:r:Ribavirin ADME", "R-RNO-9748787:r:Azathioprine ADME", "R-PFA-9748787:r:Azathioprine ADME"], "type": "Family"}, "IPR002266": {"description": "Gap junction alpha-8 protein (Cx50), C-terminal", "go_ids": ["GO:0005922", "GO:0007154"], "go_terms": ["GO:0005922:connexin complex:C", "GO:0007154:cell communication:P"], "name": "Connexin50_C", "pathway_ids": ["R-HSA-190861", "R-GGA-190861", "R-MMU-190861", "R-RNO-190861"], "pathways": ["R-HSA-190861:r:Gap junction assembly", "R-GGA-190861:r:Gap junction assembly", "R-MMU-190861:r:Gap junction assembly", "R-RNO-190861:r:Gap junction assembly"], "type": "Domain"}, "IPR002288": {"description": "DNA gyrase B subunit, C-terminal", "go_ids": ["GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F", "GO:0005524:ATP binding:F", "GO:0006265:DNA topological change:P"], "name": "DNA_gyrase_B_C", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638771"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638771:r:Action of antimicrobials"], "type": "Domain"}, "IPR002292": {"description": "Ornithine/putrescine carbamoyltransferase", "go_ids": ["GO:0016743"], "go_terms": ["GO:0016743:carboxyl- or carbamoyltransferase activity:F"], "name": "Orn/put_carbamltrans", "pathway_ids": ["PWY-6344", "PWY-7400", "PWY-8187", "PWY-4984", "R-MMU-70635", "R-HSA-9956553", "R-SPO-70635", "R-GGA-187630", "R-GGA-70635", "R-HSA-1268020", "R-GGA-1268020", "R-MMU-1268020", "R-HSA-70635", "R-HSA-9956551", "R-SCE-1268020", "R-RNO-70635", "R-SCE-70635", "R-SPO-1268020", "R-RNO-1268020"], "pathways": ["PWY-6344:t:L-arginine degradation XIV (oxidative Stickland reaction)", "PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-8187:t:L-arginine degradation XIII (reductive Stickland reaction)", "PWY-4984:t:urea cycle", "R-MMU-70635:r:Urea cycle", "R-HSA-9956553:r:OTC main chain variants cause OTC deficiency", "R-SPO-70635:r:Urea cycle", "R-GGA-187630:r:Arginine metabolism", "R-GGA-70635:r:Urea cycle", "R-HSA-1268020:r:Mitochondrial protein import", "R-GGA-1268020:r:Mitochondrial protein import", "R-MMU-1268020:r:Mitochondrial protein import", "R-HSA-70635:r:Urea cycle", "R-HSA-9956551:r:OTC leader sequence variants cause OTC deficiency", "R-SCE-1268020:r:Mitochondrial protein import", "R-RNO-70635:r:Urea cycle", "R-SCE-70635:r:Urea cycle", "R-SPO-1268020:r:Mitochondrial protein import", "R-RNO-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR002293": {"description": "Amino 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the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-HSA-5660862:r:Defective SLC7A7 causes lysinuric protein intolerance (LPI)", "R-HSA-5660883:r:Defective SLC7A9 causes cystinuria (CSNU)", "R-XTR-352230:r:Amino acid transport across the plasma membrane", "R-RNO-71240:r:Tryptophan catabolism", "R-DRE-210991:r:Basigin interactions", "R-HSA-210991:r:Basigin interactions", "R-DRE-352230:r:Amino acid transport across the plasma membrane", "R-SCE-352230:r:Amino acid transport across the plasma membrane"], "type": "Family"}, "IPR002295": {"description": "N4/N6-methyltransferase, Type III restriction-modification enzyme EcoPI Mod subunit-like", "go_ids": ["GO:0003677", "GO:0008170"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008170:N-methyltransferase activity:F"], "name": "N4/N6-MTase_EcoPI_Mod-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002297": {"description": "DNA-directed DNA-polymerase, family A, mitochondria", "go_ids": 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"R-HSA-1474228", "R-HSA-5619058", "R-SSC-2473224", "R-MMU-1592389", "R-HSA-3000171", "R-HSA-1971475", "R-CEL-114608", "R-HSA-9694614", "R-HSA-419037", "R-BTA-3000497", "R-HSA-9820960", "R-HSA-3560801", "R-HSA-163125", "R-RNO-381426", "R-DRE-2473224", "R-HSA-9754706", "R-MMU-879518", "R-MMU-9754706", "R-MMU-6809371", "R-MMU-9913351", "R-HSA-5619110", "R-HSA-4420332", "R-HSA-9749641", "R-MMU-6798695", "R-RNO-6798695", "R-MMU-114608", "R-HSA-879518", "R-HSA-3000497", "R-HSA-6809371", "R-HSA-9725554", "R-GGA-163125", "R-DRE-1474228", "R-HSA-1251985", "R-SSC-114608", "R-BTA-201451", "R-HSA-201451", "R-MMU-3000497", "R-HSA-9925561", "R-HSA-2559582", "R-BTA-2473224", "R-DME-879518", "R-MMU-166665", "R-HSA-2473224", "R-BTA-879518", "R-HSA-189483", "R-RNO-114608", "R-HSA-114608", "R-BTA-114608", "R-HSA-3656253", "R-RNO-2473224", "R-HSA-977606", "R-RNO-159418", "R-RNO-8957275", "R-RNO-9754706", "R-BTA-381426", "R-HSA-2024096", "R-MMU-2022928", "R-MMU-201451", "R-HSA-9833110", "R-HSA-2022928", "R-RNO-975634", "R-RNO-201451", "R-HSA-9918481", "R-BTA-6809371", "R-HSA-5619095", "R-RNO-6809371", "R-MMU-977606", "R-HSA-216083", "R-DME-6798695", "R-HSA-9913351", "R-HSA-1592389", "R-RNO-879518", "R-MMU-9793528", "R-RNO-9913351", "R-RNO-1971475", "R-RNO-166665", "R-RNO-2022928", "R-HSA-9793528", "R-RNO-9749641", "R-HSA-8957275", "R-SSC-3000497", "R-HSA-159418", "R-MMU-2473224", "R-MMU-1971475", "R-MMU-159418", "R-HSA-975634"], "pathways": ["R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-2024096:r:HS-GAG degradation", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024096:r:HS-GAG degradation", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-975634:r:Retinoid metabolism and transport", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-189483:r:Heme degradation", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-HSA-166665:r:Terminal pathway of complement", "R-MMU-3000178:r:ECM proteoglycans", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-189483:r:Heme degradation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-5619058:r:Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)", "R-SSC-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-114608:r:Platelet degranulation", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-419037:r:NCAM1 interactions", "R-BTA-3000497:r:Scavenging by Class H Receptors", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-9754706:r:Atorvastatin ADME", "R-MMU-879518:r:Organic anion transport by SLCO transporters", "R-MMU-9754706:r:Atorvastatin ADME", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-5619110:r:Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-879518:r:Organic anion transport by SLCO transporters", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-114608:r:Platelet degranulation", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-2473224:r:Antagonism of Activin by Follistatin", "R-DME-879518:r:Organic anion transport by SLCO transporters", "R-MMU-166665:r:Terminal pathway of complement", "R-HSA-2473224:r:Antagonism of Activin by Follistatin", "R-BTA-879518:r:Organic anion transport by SLCO transporters", "R-HSA-189483:r:Heme degradation", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-RNO-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-9754706:r:Atorvastatin ADME", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2024096:r:HS-GAG degradation", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-MMU-201451:r:Signaling by BMP", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-201451:r:Signaling by BMP", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6809371:r:Formation of the cornified envelope", "R-HSA-5619095:r:Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)", "R-RNO-6809371:r:Formation of the cornified envelope", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-216083:r:Integrin cell surface interactions", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-879518:r:Organic anion transport by SLCO transporters", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-RNO-9749641:r:Aspirin ADME", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-3000497:r:Scavenging by Class H Receptors", "R-HSA-159418:r:Recycling of bile acids and salts", "R-MMU-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-159418:r:Recycling of bile acids and salts", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Domain"}, "IPR002351": {"description": "Nitrophorin domain", "go_ids": ["GO:0051381", "GO:0070026"], "go_terms": ["GO:0051381:histamine binding:F", "GO:0070026:nitric oxide binding:F"], "name": "Nitrophorin_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002354": {"description": "Interleukin-4", "go_ids": ["GO:0005136", "GO:0005576", "GO:0006955", "GO:0008083"], "go_terms": ["GO:0005136:interleukin-4 receptor binding:F", "GO:0005576:extracellular region:C", "GO:0006955:immune response:P", "GO:0008083:growth factor activity:F"], "name": "IL-4", "pathway_ids": ["R-CFA-6785807", "R-RNO-6785807", "R-SSC-6785807", "R-HSA-6785807", "R-BTA-6785807", "R-MMU-6785807", "R-HSA-9012546"], "pathways": ["R-CFA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-BTA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9012546:r:Interleukin-18 signaling"], "type": "Family"}, "IPR002362": {"description": "Light-harvesting protein B beta chain", "go_ids": ["GO:0016020", "GO:0019684", "GO:0030077"], "go_terms": ["GO:0016020:membrane:C", "GO:0019684:photosynthesis, light reaction:P", "GO:0030077:plasma membrane light-harvesting complex:C"], "name": "LHB-1/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002366": {"description": "Alpha-defensin, N-terminal", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "Alpha-defensin_N", "pathway_ids": ["R-RNO-1462054", "R-HSA-6798695", "R-HSA-1462054", "R-RNO-1461973", "R-HSA-9841251", "R-MMU-6798695", "R-MMU-1461973", "R-MMU-1462054", "R-RNO-6798695", "R-HSA-1461973"], "pathways": ["R-RNO-1462054:r:Alpha-defensins", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1462054:r:Alpha-defensins", "R-RNO-1461973:r:Defensins", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-1461973:r:Defensins", "R-MMU-1462054:r:Alpha-defensins", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-1461973:r:Defensins"], "type": "Domain"}, "IPR002369": {"description": "Integrin beta subunit, VWA domain", "go_ids": [], "go_terms": [], "name": "Integrin_bsu_VWA", "pathway_ids": ["R-DME-2173789", "R-HSA-8874081", "R-MMU-210991", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-MMU-9013408", "R-MMU-210990", "R-CEL-3000178", "R-HSA-9856532", "R-MMU-445355", "R-CEL-1566948", "R-DME-445355", "R-MMU-3000170", "R-CEL-446343", "R-RNO-9634597", "R-RNO-210990", "R-DME-446343", "R-MMU-202733", "R-CEL-198933", "R-HSA-8875513", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-446107", "R-HSA-6802955", "R-HSA-210991", "R-RNO-446343", "R-DME-9013149", "R-HSA-6802948", "R-DME-210991", "R-RNO-445144", "R-RNO-1566977", "R-BTA-1566948", "R-DME-114608", "R-MMU-9634597", "R-CEL-5674135", "R-HSA-9609690", "R-HSA-447041", "R-DME-216083", "R-MMU-9013423", "R-HSA-2022090", "R-MMU-216083", "R-HSA-445144", "R-MMU-354192", "R-MMU-9860927", "R-MMU-446107", "R-HSA-9656223", "R-HSA-9634597", "R-MMU-5674135", "R-RNO-216083", "R-RNO-9860927", "R-HSA-9013423", "R-RNO-8874081", "R-HSA-114608", "R-MMU-8874081", "R-RNO-354192", "R-CEL-354192", "R-RNO-5674135", "R-BTA-2129379", "R-RNO-2173789", "R-CEL-9013423", "R-MMU-3000157", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-3000170", "R-MMU-1566977", "R-DME-202733", "R-RNO-446107", "R-DME-6798695", "R-DME-446107", "R-MMU-354194", "R-MMU-1236973", "R-RNO-9013423", "R-CEL-445355", "R-HSA-5663220", "R-MMU-9013149", "R-RNO-3000170", "R-BTA-216083", "R-HSA-202733", "R-HSA-6798695", "R-HSA-5674135", "R-HSA-166016", "R-DME-198933", "R-CEL-6798695", "R-CEL-354194", "R-BTA-6798695", "R-RNO-3000157", "R-RNO-9013149", "R-MMU-4420097", "R-MMU-9013404", "R-HSA-9927418", "R-BTA-2173789", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-HSA-446343", "R-RNO-202733", "R-CEL-202733", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-3000178", "R-HSA-2173789", "R-CEL-216083", "R-BTA-198933", "R-CEL-9860927", "R-RNO-198933", "R-CEL-1236973", "R-MMU-166016", "R-CEL-114608", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-RNO-1566948", "R-DME-354192", "R-BTA-166016", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-75892", "R-MMU-198933", "R-DME-445144", "R-HSA-198933", "R-MMU-8875513", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-372708", "R-RNO-4420097", "R-MMU-114608", "R-HSA-9725554", "R-HSA-3000157", "R-CEL-1566977", "R-BTA-3000178", "R-HSA-1566948", "R-DME-9860927", "R-RNO-354194", "R-RNO-2129379", "R-CEL-9013149", "R-RNO-114608", "R-BTA-202733", "R-MMU-372708", "R-HSA-210990", "R-RNO-8875513", "R-DME-1236973", "R-HSA-416700", "R-HSA-6802946", "R-DME-2129379", "R-HSA-9938206", "R-MMU-446343", "R-HSA-354192", "R-CEL-210991", "R-HSA-216083", "R-HSA-445355", "R-RNO-210991", "R-CEL-445144", "R-HSA-1566977", "R-HSA-9927432", "R-HSA-354194", "R-HSA-9679191", "R-HSA-9830674", "R-DME-3000170", "R-CEL-4420097", "R-DME-9013423", "R-MMU-2129379"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-445355:r:Smooth Muscle Contraction", "R-CEL-1566948:r:Elastic fibre formation", "R-DME-445355:r:Smooth Muscle Contraction", "R-MMU-3000170:r:Syndecan interactions", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-9634597:r:GPER1 signaling", "R-RNO-210990:r:PECAM1 interactions", "R-DME-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-210991:r:Basigin interactions", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-1566977:r:Fibronectin matrix formation", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-447041:r:CHL1 interactions", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000157:r:Laminin interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-1566948:r:Elastic fibre formation", "R-DME-354192:r:Integrin signaling", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-CEL-1566977:r:Fibronectin matrix formation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-1566948:r:Elastic fibre formation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-354192:r:Integrin signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-210991:r:Basigin interactions", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR002371": {"description": "Flagellar hook-associated protein 1", "go_ids": ["GO:0005198", "GO:0009424", "GO:0044780"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0009424:bacterial-type flagellum hook:C", "GO:0044780:bacterial-type flagellum assembly:P"], "name": "FlgK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002372": {"description": "Pyrrolo-quinoline quinone repeat domain", "go_ids": [], "go_terms": [], "name": "PQQ_rpt_dom", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR002374": {"description": "cGMP-dependent kinase", "go_ids": ["GO:0004692", "GO:0005524"], "go_terms": ["GO:0004692:cGMP-dependent protein kinase activity:F", "GO:0005524:ATP binding:F"], "name": "cGMP_dep_kinase", "pathway_ids": ["R-PFA-8963896", "R-PFA-9837999", "R-PFA-164378", "R-HSA-1474151", "R-MMU-9648002", "R-CEL-392517", "R-MMU-392517", "R-HSA-9918432", "R-PFA-5687128", "R-PFA-442720", "R-PFA-5610787", "R-MMU-418457", "R-PFA-381676", "R-BTA-418457", "R-CEL-9648002", "R-MMU-1474151", "R-DME-9648002", "R-PFA-432040", "R-HSA-418457", "R-PFA-163615", "R-DME-392517", "R-PFA-180024", "R-RNO-1474151", "R-BTA-392517", "R-RNO-418457", "R-DME-1474151", "R-HSA-4086398", "R-CEL-1474151", "R-RNO-9648002", "R-HSA-9648002", "R-HSA-392517", "R-PFA-9634597", "R-PFA-9856530"], "pathways": ["R-PFA-8963896:r:HDL assembly", "R-PFA-9837999:r:Mitochondrial protein degradation", "R-PFA-164378:r:PKA activation in glucagon signalling", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-9648002:r:RAS processing", "R-CEL-392517:r:Rap1 signalling", "R-MMU-392517:r:Rap1 signalling", "R-HSA-9918432:r:Maturation of DENV proteins", "R-PFA-5687128:r:MAPK6/MAPK4 signaling", "R-PFA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-PFA-5610787:r:Hedgehog 'off' state", "R-MMU-418457:r:cGMP effects", "R-PFA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-418457:r:cGMP effects", "R-CEL-9648002:r:RAS processing", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DME-9648002:r:RAS processing", "R-PFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-418457:r:cGMP effects", "R-PFA-163615:r:PKA activation", "R-DME-392517:r:Rap1 signalling", "R-PFA-180024:r:DARPP-32 events", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-BTA-392517:r:Rap1 signalling", "R-RNO-418457:r:cGMP effects", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-4086398:r:Ca2+ pathway", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-9648002:r:RAS processing", "R-HSA-9648002:r:RAS processing", "R-HSA-392517:r:Rap1 signalling", "R-PFA-9634597:r:GPER1 signaling", "R-PFA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Family"}, "IPR002376": {"description": "Formyl transferase, N-terminal", "go_ids": ["GO:0009058"], "go_terms": ["GO:0009058:biosynthetic process:P"], "name": "Formyl_transf_N", "pathway_ids": ["R-DME-73817", "R-MMU-196757", "R-HSA-5368286", "R-RNO-196757", "R-BTA-73817", "R-MMU-73817", "R-XTR-196757", "R-HSA-73817", "R-HSA-196757", "R-GGA-419140"], "pathways": ["R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-196757:r:Metabolism of folate and pterines", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-RNO-196757:r:Metabolism of folate and pterines", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-XTR-196757:r:Metabolism of folate and pterines", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-196757:r:Metabolism of folate and pterines", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Domain"}, "IPR002379": {"description": "V-ATPase proteolipid subunit C-like domain", "go_ids": ["GO:0015078", "GO:1902600", "GO:0033177"], "go_terms": ["GO:0015078:proton transmembrane transporter activity:F", "GO:1902600:proton transmembrane transport:P", "GO:0033177:proton-transporting two-sector ATPase complex, proton-transporting domain:C"], "name": "ATPase_proteolipid_c-like_dom", "pathway_ids": ["R-HSA-6798695", "R-CEL-1222556", "R-MMU-1222556", "R-DDI-77387", "R-DME-1222556", "R-HSA-77387", "R-CEL-6798695", "R-MMU-9639288", "R-SPO-9639288", "R-HSA-9639288", "R-RNO-983712", "R-HSA-1268020", "R-SPO-917977", "R-BTA-8949613", "R-MMU-1268020", "R-CEL-9639288", "R-SPO-1222556", "R-RNO-917977", "R-DDI-6798695", 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"R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DRE-9948011:r:CASP5 inflammasome assembly", "R-RNO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-9948011:r:CASP5 inflammasome assembly", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-111458:r:Formation of apoptosome", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-111458:r:Formation of apoptosome", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-DME-3371378:r:Regulation by c-FLIP", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-448706:r:Interleukin-1 processing", "R-DRE-9948001:r:CASP4 inflammasome assembly", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-RNO-352238:r:Breakdown of the nuclear lamina", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-5620971:r:Pyroptosis", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-9960519:r:CASP4-mediated substrate 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"R-HSA-9627069:r:Regulation of the apoptosome activity", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-MMU-2028269:r:Signaling by Hippo", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-5218900:r:CASP8 activity is inhibited", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-352238:r:Breakdown of the nuclear lamina", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-9948001:r:CASP4 inflammasome assembly", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9948011:r:CASP5 inflammasome assembly", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-205025:r:NADE modulates death signalling", "R-DME-75153:r:Apoptotic execution phase", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-5620971:r:Pyroptosis", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-844615:r:The AIM2 inflammasome", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Family"}, "IPR002399": {"description": "Cytochrome P450, mitochondrial", "go_ids": ["GO:0004497", "GO:0005506", "GO:0005739", "GO:0020037", "GO:0016705"], "go_terms": ["GO:0004497:monooxygenase activity:F", 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biosynthesis"], "type": "Family"}, "IPR002401": {"description": "Cytochrome P450, E-class, group I", "go_ids": ["GO:0004497", "GO:0005506", "GO:0020037", "GO:0016705"], "go_terms": ["GO:0004497:monooxygenase activity:F", "GO:0005506:iron ion binding:F", "GO:0020037:heme binding:F", "GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F"], "name": "Cyt_P450_E_grp-I", "pathway_ids": ["R-RNO-193807", "R-DRE-211976", "R-SSC-2162123", "R-MMU-9753281", "R-CEL-211945", "R-RNO-9753281", "R-RNO-211957", "R-RNO-5423646", "R-DRE-211916", "R-HSA-211979", "R-MMU-5423646", "R-DME-2453902", "R-HSA-193048", "R-BTA-211999", "R-CEL-193144", "R-BTA-193993", "R-HSA-2453902", "R-RNO-193144", "R-MMU-2142816", "R-HSA-196108", "R-SSC-193144", "R-RNO-2142816", "R-HSA-193775", "R-HSA-5579032", "R-DME-193144", "R-CEL-211916", "R-HSA-5579026", "R-MMU-156581", "R-BTA-193048", "R-HSA-211999", "R-RNO-211945", "R-RNO-193775", "R-SSC-2142816", "R-MMU-211976", "R-HSA-9749641", "R-SSC-211935", "R-MMU-211999", "R-DRE-5365859", "R-MMU-193807", "R-CEL-5423646", "R-HSA-211945", "R-DDI-9749641", "R-CFA-9753281", "R-MMU-193775", "R-CEL-9027307", "R-MMU-211935", "R-DDI-2142670", "R-HSA-193368", "R-RNO-193993", "R-RNO-193048", "R-MMU-196108", "R-HSA-196791", "R-DME-196791", "R-DDI-211981", "R-DME-2142816", "R-HSA-5579011", "R-HSA-9027307", "R-RNO-211958", "R-BTA-9749641", "R-SSC-194002", "R-RNO-211935", "R-MMU-193368", "R-MMU-2162123", "R-DME-211958", "R-MMU-2142670", "R-SSC-211958", "R-BTA-211958", "R-RNO-2453902", "R-CEL-9749641", "R-RNO-9027307", "R-MMU-193993", "R-MMU-211979", "R-HSA-5579028", "R-HSA-211958", "R-BTA-9027307", "R-HSA-5579030", "R-RNO-9018681", "R-HSA-193144", "R-DDI-211999", "R-HSA-5579005", "R-HSA-5579027", "R-DDI-196791", "R-HSA-2142816", "R-HSA-1989781", "R-HSA-211981", "R-HSA-2142691", "R-CEL-2142670", "R-DRE-193144", "R-DME-211916", "R-HSA-5423646", "R-BTA-211976", "R-DDI-2142816", "R-DDI-211958", 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"R-RNO-194002", "R-RNO-196108", "R-SSC-193048", "R-DME-211935", "R-RNO-2142691", "R-CFA-211981", "R-SSC-211979", "R-CFA-9749641", "R-MMU-211916", "R-RNO-2142670", "R-HSA-156581", "R-RNO-9749641", "R-MMU-193144", "R-HSA-211935", "R-DDI-9753281", "R-HSA-194002"], "pathways": ["R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DRE-211976:r:Endogenous sterols", "R-SSC-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-9753281:r:Paracetamol ADME", "R-CEL-211945:r:Phase I - Functionalization of compounds", "R-RNO-9753281:r:Paracetamol ADME", "R-RNO-211957:r:Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-DRE-211916:r:Vitamins", "R-HSA-211979:r:Eicosanoids", "R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-193048:r:Androgen biosynthesis", "R-BTA-211999:r:CYP2E1 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"R-GGA-9837999:r:Mitochondrial protein degradation", "R-CEL-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-389957:r:Prefoldin mediated transfer of substrate to CCT/TriC", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Family"}, "IPR002429": {"description": "Cytochrome c oxidase subunit II-like C-terminal", "go_ids": ["GO:0004129", "GO:0005507", "GO:0016020"], "go_terms": ["GO:0004129:cytochrome-c oxidase activity:F", "GO:0005507:copper ion binding:F", "GO:0016020:membrane:C"], "name": "CcO_II-like_C", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279", "R-GGA-9707564", "R-HSA-5419276", "R-DME-5628897", "R-DRE-611105", "R-GGA-9864848", "R-DRE-9864848", "R-BTA-9864848", "R-HSA-5628897", "R-GGA-5419276", "R-DME-9864848", "R-RNO-5419276", "R-HSA-9707564", "R-GGA-611105", "R-MMU-5628897", "R-MMU-611105", "R-HSA-9837999", "R-MMU-9864848", "R-DRE-5419276", "R-DDI-9837999", "R-DME-9707564", "R-RNO-5628897", "R-RNO-9707564", "R-DME-611105", "R-BTA-5628897", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-GGA-5628897", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-DRE-9707564", "R-DRE-5628897", "R-RNO-9864848", "R-MMU-9707564", "R-BTA-611105", "R-BTA-9707564"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-611105:r:Respiratory electron transport", "R-GGA-9864848:r:Complex IV assembly", "R-DRE-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-5419276:r:Mitochondrial translation termination", "R-DME-9864848:r:Complex IV assembly", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-GGA-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9864848:r:Complex IV assembly", "R-DRE-5419276:r:Mitochondrial translation termination", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-DME-611105:r:Respiratory electron transport", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR002433": {"description": "Ornithine decarboxylase", "go_ids": ["GO:0006596"], "go_terms": ["GO:0006596:polyamine biosynthetic process:P"], "name": "Orn_de-COase", "pathway_ids": ["PWY-46", "R-CEL-351143", "R-HSA-351143", "R-SPO-351143", "R-SPO-351202", "R-DME-351143", "R-CEL-351202", "R-SPO-350562", "R-MMU-350562", "R-RNO-351143", "R-BTA-350562", "R-DME-350562", "R-HSA-351202", "R-DME-351202", "R-RNO-351202", "R-RNO-350562", "R-DDI-351202", "R-MMU-351143", "R-SCE-351143", "R-DDI-351143", "R-MMU-351202", "R-SCE-351202", "R-CEL-350562", "R-HSA-350562", "R-BTA-351202"], "pathways": ["PWY-46:t:putrescine biosynthesis III", "R-CEL-351143:r:Agmatine biosynthesis", "R-HSA-351143:r:Agmatine biosynthesis", "R-SPO-351143:r:Agmatine biosynthesis", "R-SPO-351202:r:Metabolism of polyamines", "R-DME-351143:r:Agmatine biosynthesis", "R-CEL-351202:r:Metabolism of polyamines", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-351143:r:Agmatine biosynthesis", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-351202:r:Metabolism of polyamines", "R-DME-351202:r:Metabolism of polyamines", "R-RNO-351202:r:Metabolism of polyamines", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-351202:r:Metabolism of polyamines", "R-MMU-351143:r:Agmatine biosynthesis", "R-SCE-351143:r:Agmatine biosynthesis", "R-DDI-351143:r:Agmatine biosynthesis", "R-MMU-351202:r:Metabolism of polyamines", "R-SCE-351202:r:Metabolism of polyamines", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-BTA-351202:r:Metabolism of polyamines"], "type": "Family"}, "IPR002449": {"description": "Retinol binding protein/Purpurin", "go_ids": ["GO:0005501", "GO:0034632"], "go_terms": ["GO:0005501:retinoid binding:F", "GO:0034632:retinol transmembrane transporter activity:F"], "name": "Retinol-bd/Purpurin", "pathway_ids": ["R-MMU-975634", "R-HSA-6809583", "R-GGA-975634", "R-HSA-9918449", "R-MMU-2453902", "R-RNO-975634", "R-RNO-2453902", "R-HSA-975634", "R-GGA-2453902", "R-HSA-2453902"], "pathways": ["R-MMU-975634:r:Retinoid metabolism and transport", "R-HSA-6809583:r:Retinoid metabolism disease events", "R-GGA-975634:r:Retinoid metabolism and transport", "R-HSA-9918449:r:Defective visual phototransduction due to STRA6 loss of function", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-975634:r:Retinoid metabolism and transport", "R-GGA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Family"}, "IPR002455": {"description": "GPCR family 3, GABA-B receptor", "go_ids": ["GO:0004965", "GO:0007186", "GO:0016020"], "go_terms": ["GO:0004965:G protein-coupled GABA receptor activity:F", "GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "GPCR3_GABA-B", "pathway_ids": ["R-MMU-977444", "R-HSA-977444", "R-MMU-418594", "R-RNO-418594", "R-DDI-418594", "R-HSA-1296041", "R-DDI-977444", "R-HSA-997272", "R-CEL-977444", "R-RNO-997272", "R-RNO-977444", "R-MMU-420499", "R-HSA-420499", "R-RNO-420499", "R-DDI-420499", "R-CEL-418594", "R-MMU-1296041", "R-RNO-1296041", "R-HSA-418594", "R-CEL-420499", "R-MMU-997272", "R-CEL-997272", "R-CEL-1296041"], "pathways": ["R-MMU-977444:r:GABA B receptor activation", "R-HSA-977444:r:GABA B receptor activation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-DDI-418594:r:G alpha (i) signalling events", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-DDI-977444:r:GABA B receptor activation", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-977444:r:GABA B receptor activation", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-977444:r:GABA B receptor activation", "R-MMU-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-DDI-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-1296041:r:Activation of G protein gated Potassium channels"], "type": "Family"}, "IPR002463": {"description": "Ornatin", "go_ids": ["GO:0005576", "GO:0007155", "GO:0030193"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0007155:cell adhesion:P", "GO:0030193:regulation of blood coagulation:P"], "name": "Ornatin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002466": {"description": "Adenosine deaminase/editase", "go_ids": ["GO:0003723", "GO:0004000", "GO:0006396"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0004000:adenosine deaminase activity:F", "GO:0006396:RNA processing:P"], "name": "A_deamin", "pathway_ids": ["R-CEL-75102", "R-MMU-9833482", "R-RNO-77042", "R-DME-75102", "R-HSA-909733", "R-RNO-75102", "R-HSA-9833482", "R-CEL-77042", "R-HSA-6782315", "R-DME-77042", "R-MMU-75102", "R-HSA-75102", "R-RNO-9833482", "R-MMU-77042", "R-HSA-77042"], "pathways": ["R-CEL-75102:r:C6 deamination of adenosine", "R-MMU-9833482:r:PKR-mediated signaling", "R-RNO-77042:r:Formation of editosomes by ADAR proteins", "R-DME-75102:r:C6 deamination of adenosine", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-75102:r:C6 deamination of adenosine", "R-HSA-9833482:r:PKR-mediated signaling", "R-CEL-77042:r:Formation of editosomes by ADAR proteins", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-DME-77042:r:Formation of editosomes by ADAR proteins", "R-MMU-75102:r:C6 deamination of adenosine", "R-HSA-75102:r:C6 deamination of adenosine", "R-RNO-9833482:r:PKR-mediated signaling", "R-MMU-77042:r:Formation of editosomes by ADAR proteins", "R-HSA-77042:r:Formation of editosomes by ADAR proteins"], "type": "Domain"}, "IPR002467": {"description": "Peptidase M24A, methionine aminopeptidase, subfamily 1", "go_ids": ["GO:0006508", "GO:0070006"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0070006:metalloaminopeptidase activity:F"], "name": "Pept_M24A_MAP1", "pathway_ids": ["PWY-7800", "PWY-7799", "R-HSA-2514859", "R-MMU-2514859", "R-SPO-2514859", "R-BTA-2514859", "R-DRE-2514859", "R-DDI-2514859", "R-SCE-2514859", "R-GGA-2514859", "R-XTR-2514859"], "pathways": ["PWY-7800:t:Ac/N-end rule pathway", "PWY-7799:t:Arg/N-end rule pathway (eukaryotic)", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DRE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SCE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-GGA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-XTR-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Family"}, "IPR002468": {"description": "Peptidase M24A, methionine aminopeptidase, subfamily 2", "go_ids": ["GO:0006508", "GO:0070006"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0070006:metalloaminopeptidase activity:F"], "name": "Pept_M24A_MAP2", "pathway_ids": ["PWY-7800", "PWY-7799", "R-SPO-2514859", "R-CEL-2514859", "R-SCE-2514859", "R-DDI-2514859", "R-HSA-2514859", "R-RNO-2514859", "R-MMU-2514859"], "pathways": ["PWY-7800:t:Ac/N-end rule pathway", "PWY-7799:t:Arg/N-end rule pathway (eukaryotic)", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SCE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Family"}, "IPR002469": {"description": "Dipeptidylpeptidase IV, N-terminal domain", "go_ids": ["GO:0006508"], "go_terms": ["GO:0006508:proteolysis:P"], "name": "Peptidase_S9B_N", "pathway_ids": ["R-MMU-400511", "R-BTA-381771", "R-RNO-381771", "R-HSA-400511", "R-MMU-381771", "R-RNO-400511", "R-SPO-381771", "R-CEL-381771", "R-HSA-381771", "R-BTA-400511", "R-SCE-381771"], "pathways": ["R-MMU-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-BTA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-RNO-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-RNO-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-SPO-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-CEL-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-BTA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-SCE-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "type": "Domain"}, "IPR002474": {"description": "Carbamoyl-phosphate synthase small subunit, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CarbamoylP_synth_ssu_N", "pathway_ids": ["PWY-7400", "PWY-7791", "PWY-5686", "PWY-7790", "PWY-5154", "R-MMU-500753", "R-MMU-70635", "R-DME-500753", "R-HSA-500753", "R-SCE-500753", "R-SPO-500753", "R-CEL-500753", "R-HSA-70635", "R-DDI-500753", "R-HSA-9955542", "R-RNO-70635"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-MMU-500753:r:Pyrimidine biosynthesis", "R-MMU-70635:r:Urea cycle", "R-DME-500753:r:Pyrimidine biosynthesis", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-SCE-500753:r:Pyrimidine biosynthesis", "R-SPO-500753:r:Pyrimidine biosynthesis", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-HSA-70635:r:Urea cycle", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-HSA-9955542:r:CPS1 variants cause CPS1 deficiency", "R-RNO-70635:r:Urea cycle"], "type": "Domain"}, "IPR002477": {"description": "Peptidoglycan binding-like", "go_ids": [], "go_terms": [], "name": "Peptidoglycan-bd-like", "pathway_ids": ["R-HSA-6798695", "R-MMU-9839383", "R-MMU-2179392", "R-RNO-2022090", "R-MMU-210991", "R-GGA-1474228", "R-RNO-1474228", "R-BTA-1442490", "R-RNO-9009391", "R-BTA-6798695", "R-HSA-2179392", "R-MMU-9009391", "R-CFA-1442490", "R-SSC-1474228", "R-CFA-2022090", "R-RNO-2179392", "R-GGA-9009391", "R-SSC-1442490", "R-GGA-1592389", "R-HSA-210991", "R-HSA-381426", "R-HSA-1442490", "R-BTA-1433557", "R-MMU-1474228", "R-HSA-1474228", "R-CFA-2179392", "R-CFA-1592389", "R-SSC-1592389", "R-RNO-1592389", "R-MMU-1592389", "R-BTA-1474228", "R-CFA-9009391", "R-RNO-9839383", "R-HSA-9839383", "R-HSA-1592389", "R-HSA-6785807", "R-GGA-1442490", "R-RNO-1442490", "R-BTA-9009391", "R-HSA-8941332", "R-MMU-2022090", "R-HSA-9009391", "R-BTA-1592389", "R-HSA-2022090", "R-CFA-1474228", "R-GGA-3928665", "R-MMU-6798695", "R-HSA-9856530", "R-BTA-3928665", "R-MMU-1442490", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-210991:r:Basigin interactions", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-BTA-1442490:r:Collagen degradation", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-1442490:r:Collagen degradation", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-CFA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-1442490:r:Collagen degradation", "R-GGA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-210991:r:Basigin interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-CFA-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-SSC-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-1442490:r:Collagen degradation", "R-RNO-1442490:r:Collagen degradation", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1442490:r:Collagen degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR002478": {"description": "PUA domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "PUA", "pathway_ids": ["PWY-6922", "R-MMU-6791226", "R-CEL-171319", "R-RNO-6791226", "R-SPO-171319", "R-HSA-6791226", "R-GGA-417076", "R-DME-171319", "R-SCE-171319", "R-DRE-171319", "R-RNO-171319", "R-DDI-171319", "R-HSA-6790901", "R-HSA-171319", "R-MMU-171319"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-171319:r:Telomere Extension By Telomerase", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-GGA-417076:r:Assembly of telomerase and telomere extension", "R-DME-171319:r:Telomere Extension By Telomerase", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DDI-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR002480": {"description": "DAHP synthetase, class II", "go_ids": ["GO:0003849", "GO:0009073"], "go_terms": ["GO:0003849:3-deoxy-7-phosphoheptulonate synthase activity:F", "GO:0009073:aromatic amino acid biosynthetic process:P"], "name": "DAHP_synth_2", "pathway_ids": ["PWY-6164", "R-MTU-964903"], "pathways": ["PWY-6164:t:3-dehydroquinate biosynthesis I", "R-MTU-964903:r:Chorismate via Shikimate Pathway"], "type": "Family"}, "IPR002481": {"description": "Ferric-uptake regulator", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "FUR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002483": {"description": "PWI domain", "go_ids": [], "go_terms": [], "name": "PWI_dom", "pathway_ids": ["R-MMU-9930044", "R-HSA-9930044", "R-HSA-9013422", "R-HSA-9013418", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-MMU-73856", "R-HSA-73856", "R-HSA-72187", "R-SPO-9930044", "R-DME-9930044", "R-MMU-159236", "R-HSA-72163", "R-SPO-9770562", "R-MMU-9013422", "R-MMU-72187", "R-HSA-159236", "R-MMU-9013418", "R-HSA-9918481"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-9930044:r:Nuclear RNA decay", "R-DME-9930044:r:Nuclear RNA decay", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR002484": {"description": "Arterivirus nucleocapsid", "go_ids": ["GO:0019013"], "go_terms": ["GO:0019013:viral nucleocapsid:C"], "name": "Arte_nucleocap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002486": {"description": "Nematode cuticle collagen, N-terminal", "go_ids": ["GO:0042302"], "go_terms": ["GO:0042302:structural constituent of cuticle:F"], "name": "Col_cuticle_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002487": {"description": "Transcription factor, K-box", "go_ids": ["GO:0003700", "GO:0005634", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "TF_Kbox", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002488": {"description": "Protein AC4", "go_ids": [], "go_terms": [], "name": "AC4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002489": {"description": "Glutamate synthase, alpha subunit, C-terminal", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Glu_synth_asu_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002490": {"description": "V-type ATPase, V0 complex, 116kDa subunit family", "go_ids": ["GO:0046961", "GO:1902600", "GO:0033179"], "go_terms": ["GO:0046961:proton-transporting ATPase activity, rotational mechanism:F", "GO:1902600:proton transmembrane transport:P", "GO:0033179:proton-transporting V-type ATPase, V0 domain:C"], "name": "V-ATPase_116kDa_su", "pathway_ids": ["R-HSA-6798695", "R-CEL-1222556", "R-SPO-6798695", "R-MMU-1222556", "R-DDI-77387", "R-SCE-9639288", "R-HSA-77387", "R-CEL-6798695", "R-SCE-6798695", "R-XTR-77387", "R-SPO-9639288", "R-RNO-1222556", "R-HSA-9639288", "R-RNO-983712", "R-XTR-1222556", "R-XTR-917977", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-XTR-983712", "R-RNO-917977", "R-DDI-6798695", "R-SCE-1222556", "R-MMU-77387", "R-SCE-917977", "R-BTA-1222556", "R-DDI-9639288", "R-SCE-77387", "R-BTA-983712", "R-XTR-6798695", "R-RNO-77387", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-CEL-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-MMU-6798695", "R-HSA-917977", "R-MMU-983712", "R-DDI-917977", "R-DDI-983712", "R-BTA-77387", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-HSA-77387:r:Insulin receptor recycling", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-XTR-77387:r:Insulin receptor recycling", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-RNO-983712:r:Ion channel transport", "R-XTR-1222556:r:ROS and RNS production in phagocytes", "R-XTR-917977:r:Transferrin endocytosis and recycling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-XTR-983712:r:Ion channel transport", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-MMU-77387:r:Insulin receptor recycling", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-SCE-77387:r:Insulin receptor recycling", "R-BTA-983712:r:Ion channel transport", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-77387:r:Insulin receptor recycling", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-CEL-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-DDI-983712:r:Ion channel transport", "R-BTA-77387:r:Insulin receptor recycling", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR002491": {"description": "ABC transporter periplasmic binding domain", "go_ids": [], "go_terms": [], "name": "ABC_transptr_periplasmic_BD", "pathway_ids": ["R-HSA-9638334", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR002492": {"description": "Transposase, Tc1-like", "go_ids": ["GO:0003677", "GO:0006313", "GO:0015074"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006313:DNA transposition:P", "GO:0015074:DNA integration:P"], "name": "Transposase_Tc1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002493": {"description": "Capsid vertex component 2", "go_ids": ["GO:0019028", "GO:0019072"], "go_terms": ["GO:0019028:viral capsid:C", "GO:0019072:viral genome packaging:P"], "name": "CVC2", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR002494": {"description": "Keratin-associated protein", "go_ids": ["GO:0045095"], "go_terms": ["GO:0045095:keratin filament:C"], "name": "KAP", "pathway_ids": ["R-BTA-6805567", "R-MMU-6805567", "R-HSA-6805567"], "pathways": ["R-BTA-6805567:r:Keratinization", "R-MMU-6805567:r:Keratinization", "R-HSA-6805567:r:Keratinization"], "type": "Family"}, "IPR002495": {"description": "Glycosyl transferase, family 8", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "Glyco_trans_8", "pathway_ids": ["R-MMU-70221", "R-HSA-6798695", "R-SPO-6798695", "R-CEL-3322077", "R-HSA-70221", "R-MMU-3322077", "R-HSA-5357609", "R-CEL-6798695", "R-MMU-9939291", "R-SCE-6798695", "R-SCE-3322077", "R-HSA-3785653", "R-DRE-9939291", "R-CEL-70221", "R-RNO-70221", "R-HSA-3858516", "R-HSA-5083627", "R-SCE-70221", "R-HSA-3322077", "R-SPO-70221", "R-HSA-9926550", "R-HSA-3878781", "R-HSA-3814836", "R-HSA-3828062", "R-MMU-6798695", "R-HSA-9939291", "R-RNO-9939291", "R-RNO-3322077", "R-RNO-6798695"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", 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"R-HSA-3878781:r:Glycogen storage disease type IV (GBE1)", "R-HSA-3814836:r:Glycogen storage disease type XV (GYG1)", "R-HSA-3828062:r:Glycogen storage disease type 0 (muscle GYS1)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-RNO-9939291:r:Matriglycan biosynthesis on DAG1", "R-RNO-3322077:r:Glycogen synthesis", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR002496": {"description": "Phosphoribosyl-AMP cyclohydrolase domain", "go_ids": ["GO:0000105", "GO:0004635"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0004635:phosphoribosyl-AMP cyclohydrolase activity:F"], "name": "PRib_AMP_CycHydrolase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002498": {"description": "Phosphatidylinositol-4-phosphate 4/5-kinase, core", "go_ids": ["GO:0052742", "GO:0046488"], "go_terms": ["GO:0052742:phosphatidylinositol kinase activity:F", "GO:0046488:phosphatidylinositol metabolic 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plasma membrane", "R-PFA-6811555:r:PI5P Regulates TP53 Acetylation", "R-SPO-8847453:r:Synthesis of PIPs in the nucleus", "R-DRE-8847453:r:Synthesis of PIPs in the nucleus", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-201688:r:WNT mediated activation of DVL", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-PFA-8856828:r:Clathrin-mediated endocytosis", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-8847453:r:Synthesis of PIPs in the nucleus", "R-BTA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SCE-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-8847453:r:Synthesis of PIPs in the nucleus", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-201688:r:WNT mediated activation of DVL", "R-PFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-PFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-BTA-8847453:r:Synthesis of PIPs in the nucleus", "R-DRE-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-201688:r:WNT mediated activation of DVL"], "type": "Domain"}, "IPR002500": {"description": "Phosphoadenosine phosphosulphate reductase domain", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "PAPS_reduct_dom", "pathway_ids": ["R-DRE-196843", "R-MTU-936635", "R-CEL-196843", "R-MMU-196843", "R-RNO-196843", "R-SCE-196843", "R-HSA-196843", "R-MTU-936721", "R-SPO-196843"], "pathways": ["R-DRE-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MTU-936635:r:Sulfate assimilation", "R-CEL-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-SCE-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine", "R-SPO-196843:r:Vitamin B2 (riboflavin) metabolism"], "type": "Domain"}, "IPR002501": {"description": "Pseudouridine synthase II, N-terminal", "go_ids": ["GO:0006396"], "go_terms": ["GO:0006396:RNA processing:P"], "name": "PsdUridine_synth_N", "pathway_ids": ["R-HSA-9937008", "R-HSA-6793080", "R-CEL-171319", "R-SPO-171319", "R-GGA-417076", "R-DME-171319", "R-SCE-171319", "R-DRE-171319", "R-RNO-171319", "R-DDI-171319", "R-HSA-6790901", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-CEL-171319:r:Telomere Extension By Telomerase", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-GGA-417076:r:Assembly of telomerase and telomere extension", "R-DME-171319:r:Telomere Extension By Telomerase", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DDI-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR002502": {"description": "N-acetylmuramoyl-L-alanine amidase domain", "go_ids": ["GO:0008745", "GO:0009253"], "go_terms": ["GO:0008745:N-acetylmuramoyl-L-alanine amidase activity:F", "GO:0009253:peptidoglycan catabolic process:P"], "name": "Amidase_domain", "pathway_ids": ["PWY-7883", "R-HSA-6798695", "R-RNO-6803157", "R-DME-214411", "R-BTA-6803157", "R-DME-214397", "R-DME-6798695", "R-DME-209266", "R-BTA-6798695", "R-DME-6803157", "R-HSA-6803157", "R-MMU-6798695", "R-DME-214399", "R-MMU-6803157", "R-DME-214416", "R-RNO-6798695", "R-DME-209171"], "pathways": ["PWY-7883:t:peptidoglycan recycling II", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-BTA-6803157:r:Antimicrobial peptides", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-209266:r:Peptidoglycan bound PGRP-LC/LE oligomerises", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-MMU-6803157:r:Antimicrobial peptides", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-209171:r:Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE"], "type": "Domain"}, "IPR002505": {"description": "Phosphate acetyl/butaryl transferase", "go_ids": ["GO:0016746"], "go_terms": ["GO:0016746:acyltransferase activity:F"], "name": "PTA_PTB", "pathway_ids": ["PWY-8086", "PWY-1281", "PWY-8377", "PWY-5497", "PWY-5485", "PWY-6637", "PWY-5482"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1281:t:sulfoacetaldehyde degradation I", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-5485:t:pyruvate fermentation to acetate IV", "PWY-6637:t:sulfolactate degradation II", "PWY-5482:t:pyruvate fermentation to acetate II"], "type": "Domain"}, "IPR002506": {"description": "Small/Large delta antigen", "go_ids": ["GO:0046718", "GO:0003723"], "go_terms": ["GO:0046718:symbiont entry into host cell:P", "GO:0003723:RNA binding:F"], "name": "Delta_antigen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002507": {"description": "Reovirus non-structural protein sigma NS", "go_ids": ["GO:0003727", "GO:0003968"], "go_terms": ["GO:0003727:single-stranded RNA binding:F", "GO:0003968:RNA-directed RNA polymerase activity:F"], "name": "Reovirus_polyG_pol", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002508": {"description": "N-acetylmuramoyl-L-alanine amidase, catalytic domain", "go_ids": ["GO:0008745", "GO:0009253"], "go_terms": ["GO:0008745:N-acetylmuramoyl-L-alanine amidase activity:F", "GO:0009253:peptidoglycan catabolic process:P"], "name": "MurNAc-LAA_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002509": {"description": "NodB homology domain", "go_ids": ["GO:0005975", "GO:0016810"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016810:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:F"], "name": "NODB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002510": {"description": "Metalloprotease TldD/E, N-terminal domain", "go_ids": ["GO:0006508"], "go_terms": ["GO:0006508:proteolysis:P"], "name": "Metalloprtase-TldD/E_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002511": {"description": "V2 protein, geminivirus", "go_ids": ["GO:0044003", "GO:0060967", "GO:0030430"], "go_terms": ["GO:0044003:symbiont-mediated perturbation of host process:P", "GO:0060967:negative regulation of gene silencing by regulatory ncRNA:P", "GO:0030430:host cell cytoplasm:C"], "name": "Gemini_V2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002512": {"description": "Non-structural protein 5, rotavirus", "go_ids": ["GO:0019079", "GO:0000287", "GO:0016887", "GO:0030430"], "go_terms": ["GO:0019079:viral genome replication:P", "GO:0000287:magnesium ion binding:F", "GO:0016887:ATP hydrolysis activity:F", "GO:0030430:host cell cytoplasm:C"], "name": "Rotavirus_NSP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002513": {"description": "Tn3 transposase DDE domain", "go_ids": ["GO:0004803", "GO:0006313"], "go_terms": ["GO:0004803:transposase activity:F", "GO:0006313:DNA transposition:P"], "name": "Tn3_Tnp_DDE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002514": {"description": "Transposase IS3/IS911family", "go_ids": ["GO:0003677", "GO:0004803", "GO:0006313"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004803:transposase activity:F", "GO:0006313:DNA transposition:P"], "name": "Transposase_8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002515": {"description": "Zinc finger, C2H2C-type", "go_ids": ["GO:0005634", "GO:0006355", "GO:0008270"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0008270:zinc ion binding:F"], "name": "Znf_C2H2C", "pathway_ids": ["R-MMU-3214847", "R-MMU-6804760", "R-HSA-3214847", "R-RNO-3214847", "R-HSA-6804760", "R-RNO-6804760"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation"], "type": "Repeat"}, "IPR002516": {"description": "Glycosyl transferase, family 11", "go_ids": ["GO:0005975", "GO:0008107", "GO:0016020"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0008107:galactoside 2-alpha-L-fucosyltransferase activity:F", "GO:0016020:membrane:C"], "name": "Glyco_trans_11", "pathway_ids": ["PWY-7839", "PWY-7832", "PWY-7831", "PWY-7833", "PWY-8459", "R-MMU-9033807", "R-HSA-9840309", "R-RNO-9033807", "R-RNO-9037629", "R-HSA-9037629", "R-RNO-9840309", "R-SSC-9840309", "R-MMU-9840309", "R-BTA-9840309", "R-SSC-9037629", "R-SSC-9033807", "R-BTA-9033807", "R-MMU-9037629", "R-HSA-9033807"], "pathways": ["PWY-7839:t:lacto-series glycosphingolipids biosynthesis", "PWY-7832:t:ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide", "PWY-7831:t:ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide", "PWY-7833:t:biosynthesis of Lewis epitopes (H. pylori)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "R-MMU-9033807:r:ABO blood group biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-9033807:r:ABO blood group biosynthesis", "R-RNO-9037629:r:Lewis blood group biosynthesis", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-SSC-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-BTA-9840309:r:Glycosphingolipid biosynthesis", "R-SSC-9037629:r:Lewis blood group biosynthesis", "R-SSC-9033807:r:ABO blood group biosynthesis", "R-BTA-9033807:r:ABO blood group biosynthesis", "R-MMU-9037629:r:Lewis blood group biosynthesis", "R-HSA-9033807:r:ABO blood group biosynthesis"], "type": "Family"}, "IPR002517": {"description": "Tospovirus nucleocapsid protein", "go_ids": ["GO:0019013"], "go_terms": ["GO:0019013:viral nucleocapsid:C"], "name": "Tospo_nucleocap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002518": {"description": "Hepatitis C virus, Non-structural protein NS2", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "HCV_NS2", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR002519": {"description": "Hepatitis C virus, Envelope glycoprotein E1", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "HCV_Env", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR002520": {"description": "Adhesin lipoprotein", "go_ids": [], "go_terms": [], "name": "Lipoprotein_7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002521": {"description": "Hepatitis C virus, Core protein, C-terminal", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "HCV_Core_C", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR002522": {"description": "Hepatitis C virus, Core protein, N-terminal", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "HCV_core_N", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR002523": {"description": "Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB", "go_ids": ["GO:0016020", "GO:0030001", "GO:0046873", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0030001:metal ion transport:P", "GO:0046873:metal ion transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P"], "name": "MgTranspt_CorA/ZnTranspt_ZntB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002524": {"description": "Cation efflux", "go_ids": ["GO:0006812", "GO:0008324", "GO:0055085", "GO:0016020"], "go_terms": ["GO:0006812:monoatomic cation transport:P", "GO:0008324:monoatomic cation transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P", "GO:0016020:membrane:C"], "name": "Cation_efflux", "pathway_ids": ["R-RNO-264876", "R-SCE-435368", "R-HSA-264876", "R-SPO-264876", "R-MMU-425410", "R-CEL-425410", "R-XTR-435368", "R-DDI-264876", "R-RNO-435368", "R-SPO-435368", "R-SCE-425410", "R-MMU-435368", "R-CEL-435368", "R-XTR-264876", "R-MMU-264876", "R-DDI-435368", "R-DRE-264876", "R-HSA-425410", "R-SPO-425410", "R-DDI-425410", "R-DRE-435368", "R-SCE-264876", "R-HSA-435368"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-SCE-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-HSA-264876:r:Insulin processing", "R-SPO-264876:r:Insulin processing", "R-MMU-425410:r:Metal ion SLC transporters", "R-CEL-425410:r:Metal ion SLC transporters", "R-XTR-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-DDI-264876:r:Insulin processing", "R-RNO-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SPO-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SCE-425410:r:Metal ion SLC transporters", "R-MMU-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-CEL-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-XTR-264876:r:Insulin processing", "R-MMU-264876:r:Insulin processing", "R-DDI-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-DRE-264876:r:Insulin processing", "R-HSA-425410:r:Metal ion SLC transporters", "R-SPO-425410:r:Metal ion SLC transporters", "R-DDI-425410:r:Metal ion SLC transporters", "R-DRE-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SCE-264876:r:Insulin processing", "R-HSA-435368:r:Zinc efflux and compartmentalization by the SLC30 family"], "type": "Family"}, "IPR002525": {"description": "Transposase IS110-like, N-terminal", "go_ids": ["GO:0003677", "GO:0004803", "GO:0006313"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004803:transposase activity:F", "GO:0006313:DNA transposition:P"], "name": "Transp_IS110-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002527": {"description": "2B protein, picornavirus", "go_ids": [], "go_terms": [], "name": "Pico_P2B", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR002528": {"description": "Multi antimicrobial extrusion protein", "go_ids": ["GO:0015297", "GO:0016020", "GO:0055085", "GO:0042910"], "go_terms": ["GO:0015297:antiporter activity:F", "GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0042910:xenobiotic transmembrane transporter activity:F"], "name": "MATE_fam", "pathway_ids": ["R-HSA-549127", "R-SCE-549127", "R-RNO-549127", "R-MMU-549127", "R-SPO-549127", "R-DRE-549127"], "pathways": ["R-HSA-549127:r:SLC-mediated transport of organic cations", "R-SCE-549127:r:SLC-mediated transport of organic cations", "R-RNO-549127:r:SLC-mediated transport of organic cations", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-SPO-549127:r:SLC-mediated transport of organic cations", "R-DRE-549127:r:SLC-mediated transport of organic cations"], "type": "Family"}, "IPR002530": {"description": "Zein seed storage protein", "go_ids": ["GO:0045735"], "go_terms": ["GO:0045735:nutrient reservoir activity:F"], "name": "Zein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002531": {"description": "Hepatitis C virus, Non-structural protein E2/NS1", "go_ids": [], "go_terms": [], "name": "HCV_NS1", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR002532": {"description": "Hantavirus glycoprotein Gc, N-terminal domain", "go_ids": ["GO:0044423"], "go_terms": ["GO:0044423:virion component:C"], "name": "Hanta_Gc_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002533": {"description": "Alphavirus E3 spike glycoprotein", "go_ids": ["GO:0004252", "GO:0019028", "GO:0055036"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0019028:viral capsid:C", "GO:0055036:virion membrane:C"], "name": "Alpha_E3_glycop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002534": {"description": "Hantavirus glycoprotein Gn, head", "go_ids": ["GO:0044423"], "go_terms": ["GO:0044423:virion component:C"], "name": "Hanta_Gn-H", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002535": {"description": "Flavivirus polyprotein propeptide", "go_ids": [], "go_terms": [], "name": "Flavi_propep", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR002538": {"description": "Bromovirus movement protein", "go_ids": ["GO:0044156", "GO:0046740"], "go_terms": ["GO:0044156:host cell junction:C", "GO:0046740:transport of virus in host, cell to cell:P"], "name": "Bromo_MP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002539": {"description": "MaoC-like dehydratase domain", "go_ids": [], "go_terms": [], "name": "MaoC-like_dom", "pathway_ids": ["R-MMU-2046106", "R-MMU-193368", "R-DDI-390247", "R-DDI-2046106", "R-DME-9033241", "R-DME-389887", "R-RNO-2046106", "R-HSA-389887", "R-HSA-193368", "R-MMU-9033241", "R-DME-2046106", "R-RNO-9033241", "R-MMU-389887", "R-DME-193368", "R-RNO-389887", "R-DDI-389887", "R-DDI-193368", "R-HSA-390247", "R-MMU-390247", "R-HSA-75105", "R-RNO-193368", "R-HSA-9033500", "R-DME-390247", "R-HSA-2046106", "R-DDI-9033241", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-9033241:r:Peroxisomal protein import", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR002540": {"description": "Peptidase S30, polyprotein P1, potyvirus", "go_ids": ["GO:0004197", "GO:0006508"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_S30_P1_potyvir", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR002541": {"description": "Cytochrome c assembly protein", "go_ids": ["GO:0017004", "GO:0020037"], "go_terms": ["GO:0017004:cytochrome complex assembly:P", "GO:0020037:heme binding:F"], "name": "Cyt_c_assembly", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002542": {"description": "T20D4.11-like domain", "go_ids": [], "go_terms": [], "name": "T20D4.11-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002543": {"description": "FtsK domain", "go_ids": ["GO:0000166", "GO:0003677", "GO:0005524"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F"], "name": "FtsK_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002544": {"description": "FMRFamide-related peptide-like", "go_ids": ["GO:0007218"], "go_terms": ["GO:0007218:neuropeptide signaling pathway:P"], "name": "FMRFamid-related_peptide-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002545": {"description": "CheW-like domain", "go_ids": ["GO:0006935", "GO:0007165"], "go_terms": ["GO:0006935:chemotaxis:P", "GO:0007165:signal transduction:P"], "name": "CheW-lke_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002546": {"description": "Myogenic muscle-specific protein, N-terminal", "go_ids": [], "go_terms": [], "name": "MyoD_N", "pathway_ids": ["R-HSA-9839394", "R-MMU-525793", "R-SSC-525793", "R-DME-525793", "R-GGA-525793", "R-HSA-525793", "R-RNO-525793", "R-BTA-525793"], "pathways": ["R-HSA-9839394:r:TGFBR3 expression", "R-MMU-525793:r:Myogenesis", "R-SSC-525793:r:Myogenesis", "R-DME-525793:r:Myogenesis", "R-GGA-525793:r:Myogenesis", "R-HSA-525793:r:Myogenesis", "R-RNO-525793:r:Myogenesis", "R-BTA-525793:r:Myogenesis"], "type": "Domain"}, "IPR002547": {"description": "tRNA-binding domain", "go_ids": ["GO:0000049"], "go_terms": ["GO:0000049:tRNA binding:F"], "name": "tRNA-bd_dom", "pathway_ids": ["R-MMU-9856649", "R-HSA-9856649", "R-DDI-9856649", "R-HSA-2408522", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR002548": {"description": "Alphavirus E1 glycoprotein", "go_ids": ["GO:0004252", "GO:0019028", "GO:0055036"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0019028:viral capsid:C", "GO:0055036:virion membrane:C"], "name": "Alpha_E1_glycop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002549": {"description": "Transmembrane protein TqsA-like", "go_ids": [], "go_terms": [], "name": "AI-2E-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002550": {"description": "CNNM, transmembrane domain", "go_ids": [], "go_terms": [], "name": "CNNM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002551": {"description": "Spike glycoprotein S1, coronavirus", "go_ids": ["GO:0019064"], "go_terms": ["GO:0019064:fusion of virus membrane with host plasma membrane:P"], "name": "Spike_S1_CoV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002552": {"description": "Spike glycoprotein S2, coronavirus", "go_ids": ["GO:0016020", "GO:0019031", "GO:0046813", "GO:0075509", "GO:0019064", "GO:0055036", "GO:0039654"], "go_terms": ["GO:0016020:membrane:C", "GO:0019031:viral envelope:C", "GO:0046813:receptor-mediated virion attachment to host cell:P", "GO:0075509:endocytosis involved in viral entry into host cell:P", "GO:0019064:fusion of virus membrane with host plasma membrane:P", "GO:0055036:virion membrane:C", "GO:0039654:fusion of virus membrane with host endosome membrane:P"], "name": "Spike_S2_CoV", "pathway_ids": ["R-HSA-9679509", "R-HSA-9683686", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9694548", "R-HSA-9692916", "R-HSA-166662", "R-HSA-166663", "R-HSA-9694614", "R-HSA-9694322", "R-HSA-9694635"], "pathways": ["R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9694635:r:Translation of Structural Proteins"], "type": "Domain"}, "IPR002553": {"description": "Clathrin/coatomer adaptor, adaptin-like, N-terminal", "go_ids": ["GO:0006886", "GO:0016192", "GO:0030117"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P", "GO:0030117:membrane coat:C"], "name": "Clathrin/coatomer_adapt-like_N", "pathway_ids": 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"R-BTA-437239:r:Recycling pathway of L1", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SCE-8964038:r:LDL clearance", "R-BTA-2132295:r:MHC class II antigen presentation", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-8964038:r:LDL clearance", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Domain"}, "IPR002554": {"description": "Protein phosphatase 2A, regulatory B subunit, B56", "go_ids": ["GO:0000159", "GO:0007165", "GO:0019888"], "go_terms": ["GO:0000159:protein phosphatase type 2A complex:C", "GO:0007165:signal transduction:P", "GO:0019888:protein phosphatase regulator activity:F"], "name": "PP2A_B56", "pathway_ids": ["R-HSA-9833482", "R-MMU-6811558", "R-MMU-2467813", "R-CEL-195253", "R-HSA-432142", "R-CEL-5673000", "R-MMU-68877", "R-MMU-432142", "R-SCE-6811558", "R-MMU-389356", "R-MMU-9833482", "R-HSA-5673000", "R-HSA-5358747", "R-RNO-6811558", "R-RNO-196299", "R-BTA-6811558", "R-HSA-6804757", "R-HSA-5467337", "R-BTA-2500257", "R-DDI-198753", "R-RNO-195253", "R-RNO-5673000", "R-HSA-5358752", "R-HSA-198753", "R-HSA-5358749", "R-SPO-6811558", "R-HSA-163767", "R-HSA-202670", "R-MMU-196299", "R-MMU-141444", "R-BTA-432142", "R-MMU-5673000", "R-CEL-389513", "R-CEL-9833482", "R-BTA-196299", "R-SCE-202670", "R-HSA-141444", "R-HSA-9648025", "R-RNO-5675221", "R-RNO-5663220", "R-HSA-5467340", "R-HSA-9634600", "R-BTA-5675221", "R-HSA-6811558", "R-SPO-389513", "R-HSA-389356", "R-RNO-389513", "R-MMU-4641262", "R-BTA-4641262", "R-SPO-202670", "R-SCE-389513", "R-RNO-2467813", "R-CEL-6811558", "R-BTA-9648025", "R-BTA-5673000", "R-MMU-5663220", "R-SCE-198753", "R-MMU-5675221", "R-RNO-141444", "R-RNO-432142", "R-HSA-5358751", "R-SPO-198753", "R-HSA-2467813", "R-RNO-4641262", "R-BTA-195253", "R-RNO-2500257", "R-DDI-6811558", "R-BTA-389356", "R-HSA-5467348", "R-BTA-5663220", "R-HSA-196299", "R-BTA-2467813", "R-HSA-68877", "R-HSA-5339716", "R-HSA-4641262", "R-DDI-389513", "R-MMU-9648025", "R-MMU-195253", "R-HSA-180024", "R-HSA-389513", "R-HSA-195253", "R-DDI-9833482", "R-MMU-2500257", "R-HSA-381038", "R-RNO-68877", "R-HSA-2500257", "R-CEL-5675221", "R-MMU-6804757", "R-DDI-5675221", "R-DDI-202670", "R-RNO-389356", "R-MMU-389513", "R-CEL-196299", "R-BTA-389513", "R-HSA-5663220", "R-RNO-9648025", "R-BTA-141444", "R-HSA-5675221"], "pathways": ["R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-432142:r:Platelet sensitization by LDL", "R-CEL-5673000:r:RAF activation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-432142:r:Platelet sensitization by LDL", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-5673000:r:RAF activation", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-198753:r:ERK/MAPK targets", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-5673000:r:RAF activation", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-198753:r:ERK/MAPK targets", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-HSA-202670:r:ERKs are inactivated", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-432142:r:Platelet sensitization by LDL", "R-MMU-5673000:r:RAF activation", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-CEL-9833482:r:PKR-mediated signaling", "R-BTA-196299:r:Beta-catenin phosphorylation cascade", "R-SCE-202670:r:ERKs are inactivated", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-HSA-389356:r:Co-stimulation by CD28", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-BTA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SPO-202670:r:ERKs are inactivated", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-5673000:r:RAF activation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-SCE-198753:r:ERK/MAPK targets", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-432142:r:Platelet sensitization by LDL", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-SPO-198753:r:ERK/MAPK targets", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-389356:r:Co-stimulation by CD28", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-180024:r:DARPP-32 events", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DDI-202670:r:ERKs are inactivated", "R-RNO-389356:r:Co-stimulation by CD28", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR002556": {"description": "GP3 envelope glycoprotein, arterivirus", "go_ids": [], "go_terms": [], "name": "Arteri_GP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002557": {"description": "Chitin binding domain", "go_ids": ["GO:0005576", "GO:0008061"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0008061:chitin binding:F"], "name": "Chitin-bd_dom", "pathway_ids": ["R-CEL-189085", "R-HSA-6798695", "R-HSA-189085", "R-DME-6798695", "R-CEL-6798695", "R-MMU-6798695", "R-RNO-189085", "R-MMU-189085", "R-DME-189085"], "pathways": ["R-CEL-189085:r:Digestion of dietary carbohydrate", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-DME-189085:r:Digestion of dietary carbohydrate"], "type": "Domain"}, "IPR002558": {"description": "I/LWEQ domain", "go_ids": ["GO:0003779"], "go_terms": ["GO:0003779:actin binding:F"], "name": "ILWEQ_dom", "pathway_ids": ["R-CEL-8856828", "R-MMU-8856828", "R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-9700645", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-8856828", "R-MMU-399955", "R-HSA-9656223", "R-MMU-432722", "R-CEL-432722", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-DDI-114608", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-9725370", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-HSA-432722", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR002559": {"description": "Transposase IS4-like domain", "go_ids": ["GO:0003677", "GO:0004803", "GO:0006313"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004803:transposase activity:F", "GO:0006313:DNA transposition:P"], "name": "Transposase_11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002560": {"description": "Transposase IS204/IS1001/IS1096/IS1165, DDE domain", "go_ids": [], "go_terms": [], "name": "Transposase_DDE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002561": {"description": "Filoviruses glycoprotein, extracellular domain", "go_ids": [], "go_terms": [], "name": "GPC_filovir-type_extra_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002562": {"description": "3'-5' exonuclease domain", "go_ids": ["GO:0003676", "GO:0006139", "GO:0008408"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0006139:nucleobase-containing compound metabolic process:P", "GO:0008408:3'-5' exonuclease activity:F"], "name": "3'-5'_exonuclease_dom", "pathway_ids": ["R-HSA-9930044", "R-HSA-5685942", "R-HSA-3108214", "R-HSA-5693616", "R-HSA-174414", "R-HSA-9704646", "R-DME-6791226", "R-MMU-6804756", "R-MMU-5693616", "R-SPO-9930044", "R-RNO-9930044", "R-DME-9930044", "R-MMU-5685938", "R-MMU-69473", "R-HSA-174437", "R-HSA-9709570", "R-MMU-174414", "R-HSA-5693607", "R-SCE-6791226", "R-MMU-174437", "R-CEL-6791226", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-MMU-9930044", "R-MMU-6791226", "R-HSA-69473", "R-MMU-5685942", "R-HSA-9709603", "R-RNO-6791226", "R-HSA-6804756", "R-HSA-6791226", "R-HSA-9704331", "R-CEL-9930044", "R-HSA-5693554", "R-HSA-5693579", "R-SPO-6791226"], "pathways": ["R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-9930044:r:Nuclear RNA decay", "R-RNO-9930044:r:Nuclear RNA decay", "R-DME-9930044:r:Nuclear RNA decay", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR002563": {"description": "Flavin reductase-like domain", "go_ids": ["GO:0010181"], "go_terms": ["GO:0010181:FMN binding:F"], "name": "Flavin_Rdtase-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002565": {"description": "Non-structural protein NS3-like", "go_ids": [], "go_terms": [], "name": "NS3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002566": {"description": "Msp4/OMP-like", "go_ids": [], "go_terms": [], "name": "Msp4_OMP-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002567": {"description": "Envelope glycoprotein K", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "GK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002568": {"description": "RNA silencing suppressor", "go_ids": ["GO:0003676", "GO:0006355"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RNA_silencing_supp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002569": {"description": "Peptide methionine sulphoxide reductase MsrA domain", "go_ids": ["GO:0008113"], "go_terms": ["GO:0008113:peptide-methionine (S)-S-oxide reductase activity:F"], "name": "Met_Sox_Rdtase_MsrA_dom", "pathway_ids": ["R-MMU-5676934", "R-BTA-5676934", "R-HSA-1222538", "R-HSA-5676934", "R-RNO-5676934"], "pathways": ["R-MMU-5676934:r:Protein repair", "R-BTA-5676934:r:Protein repair", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages", "R-HSA-5676934:r:Protein repair", "R-RNO-5676934:r:Protein repair"], "type": "Domain"}, "IPR002571": {"description": "Heat-inducible transcription repressor HrcA", "go_ids": ["GO:0006355", "GO:0003677"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F"], "name": "HrcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002572": {"description": "Domain of unknown function DUF22", "go_ids": [], "go_terms": [], "name": "DUF22", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002574": {"description": "M matrix/glycoprotein, coronavirus", "go_ids": ["GO:0055036", "GO:0016020", "GO:0039660"], "go_terms": ["GO:0055036:virion membrane:C", "GO:0016020:membrane:C", "GO:0039660:structural constituent of virion:F"], "name": "M_CoV", "pathway_ids": ["R-HSA-9679509", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9735871", "R-HSA-9694614", "R-HSA-9694635", "R-HSA-9755779", "R-HSA-9754560", "R-HSA-918233", "R-HSA-5218920", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9692916", "R-HSA-166662", "R-HSA-389357", "R-HSA-166663", "R-HSA-1257604", "R-HSA-9683612", "R-HSA-9694594", "R-HSA-9694322"], "pathways": ["R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9694635:r:Translation of Structural Proteins", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9683612:r:Maturation of protein M", "R-HSA-9694594:r:Maturation of protein M", "R-HSA-9694322:r:Virion Assembly and Release"], "type": "Family"}, "IPR002575": {"description": "Aminoglycoside phosphotransferase", "go_ids": [], "go_terms": [], "name": "Aminoglycoside_PTrfase", "pathway_ids": ["R-MMU-71064", "R-DRE-71064", "R-BTA-71064", "R-RNO-77289", "R-HSA-71064", "R-HSA-77289", "R-MMU-77289"], "pathways": ["R-MMU-71064:r:Lysine catabolism", "R-DRE-71064:r:Lysine catabolism", "R-BTA-71064:r:Lysine catabolism", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-71064:r:Lysine catabolism", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation"], "type": "Domain"}, "IPR002577": {"description": "Helix-turn-helix, HxlR type", "go_ids": [], "go_terms": [], "name": "HTH_HxlR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002579": {"description": "Peptide methionine sulphoxide reductase MrsB domain", "go_ids": ["GO:0033743"], "go_terms": ["GO:0033743:peptide-methionine (R)-S-oxide reductase activity:F"], "name": "Met_Sox_Rdtase_MsrB_dom", "pathway_ids": ["R-MMU-5676934", "R-HSA-5676934", "R-DRE-5676934", "R-CEL-5676934", "R-DME-5676934", "R-RNO-5676934"], "pathways": ["R-MMU-5676934:r:Protein repair", "R-HSA-5676934:r:Protein repair", "R-DRE-5676934:r:Protein repair", "R-CEL-5676934:r:Protein repair", "R-DME-5676934:r:Protein repair", "R-RNO-5676934:r:Protein repair"], "type": "Domain"}, "IPR002580": {"description": "Herpesvirus UL24", "go_ids": [], "go_terms": [], "name": "Herpes_UL24", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR002582": {"description": "Holo-[acyl carrier protein] synthase", "go_ids": ["GO:0000287", "GO:0006633", "GO:0008897"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0006633:fatty acid biosynthetic process:P", "GO:0008897:holo-[acyl-carrier-protein] synthase activity:F"], "name": "ACPS", "pathway_ids": ["PWY-6012", "PWY-6289"], "pathways": ["PWY-6012:t:acyl carrier protein metabolism", "PWY-6289:t:petrobactin biosynthesis"], "type": "Family"}, "IPR002583": {"description": "Small ribosomal subunit protein bS20", "go_ids": ["GO:0003723", "GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bS20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002585": {"description": "Cytochrome ubiquinol oxidase subunit 1", "go_ids": ["GO:0009055", "GO:0019646", "GO:0070069"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0019646:aerobic electron transport chain:P", "GO:0070069:cytochrome complex:C"], "name": "Cyt-d_ubiquinol_oxidase_su_1", "pathway_ids": ["PWY-7545"], "pathways": ["PWY-7545:t:pyruvate to cytochrome bd oxidase electron transfer"], "type": "Family"}, "IPR002586": {"description": "CobQ/CobB/MinD/ParA nucleotide binding domain", "go_ids": [], "go_terms": [], "name": "CobQ/CobB/MinD/ParA_Nub-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002587": {"description": "Myo-inositol-1-phosphate synthase", "go_ids": ["GO:0004512", "GO:0006021", "GO:0008654"], "go_terms": ["GO:0004512:inositol-3-phosphate synthase activity:F", "GO:0006021:inositol biosynthetic process:P", "GO:0008654:phospholipid biosynthetic process:P"], "name": "Myo-inos-1-P_Synthase", "pathway_ids": ["PWY-6580", "PWY-2301", "PWY-6372", "PWY-4661", "PWY-6664", "R-DME-1855183", "R-DDI-1855183", "R-HSA-1855183", "R-BTA-1855183", "R-MMU-1855183", "R-PFA-1855183", "R-MTU-879299", "R-SCE-1855183", "R-RNO-1855183"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-2301:t:myo-inositol biosynthesis", "PWY-6372:t:1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)", "PWY-4661:t:1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "R-DME-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-DDI-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-BTA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-PFA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MTU-879299:r:Mycothiol biosynthesis", "R-SCE-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol"], "type": "Family"}, "IPR002588": {"description": "Alphavirus-like methyltransferase domain", "go_ids": ["GO:0003723", "GO:0006396", "GO:0008174", "GO:0016556"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006396:RNA processing:P", "GO:0008174:mRNA methyltransferase activity:F", "GO:0016556:mRNA modification:P"], "name": "Alphavirus-like_MT_dom", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR002589": {"description": "Macro domain", "go_ids": [], "go_terms": [], "name": "Macro_dom", "pathway_ids": ["R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683610", "R-HSA-9683439", "R-DRE-5696400", "R-HSA-196807", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-9694631", "R-DRE-5696395", "R-HSA-918233", "R-MMU-5696395", "R-HSA-9692916", "R-HSA-5696395", "R-HSA-5696400", "R-BTA-5696395", "R-HSA-9682708", "R-BTA-5696400", "R-HSA-9694301", "R-HSA-9679504", "R-MMU-5696400"], "pathways": ["R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-MMU-5696400:r:Dual Incision in GG-NER"], "type": "Domain"}, "IPR002591": {"description": "Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase domain", "go_ids": [], "go_terms": [], "name": "Phosphodiest/P_Trfase_dom", "pathway_ids": ["R-MMU-9840310", "R-RNO-9840310", "R-SPO-6798695", "R-HSA-6798695", "R-HSA-162710", "R-HSA-6814848", "R-HSA-9840310", "R-MMU-6814848", "R-SCE-6798695", "R-RNO-196843", "R-BTA-6798695", "R-SCE-196843", "R-HSA-199220", "R-XTR-6798695", "R-SPO-162710", "R-RNO-6814848", "R-MMU-196843", "R-CEL-196843", "R-DRE-6798695", "R-SCE-162710", "R-MMU-6798695", "R-SPO-9840310", "R-MMU-162710", "R-BTA-6814848", "R-SPO-6814848", "R-DRE-6814848", "R-SCE-9840310", "R-SCE-6814848", "R-HSA-196843", "R-SPO-196843"], "pathways": ["R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-6814848:r:Glycerophospholipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-MMU-6814848:r:Glycerophospholipid catabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-BTA-6798695:r:Neutrophil degranulation", "R-SCE-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-XTR-6798695:r:Neutrophil degranulation", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-6814848:r:Glycerophospholipid catabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-CEL-196843:r:Vitamin B2 (riboflavin) metabolism", "R-DRE-6798695:r:Neutrophil degranulation", "R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-9840310:r:Glycosphingolipid catabolism", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-BTA-6814848:r:Glycerophospholipid catabolism", "R-SPO-6814848:r:Glycerophospholipid catabolism", "R-DRE-6814848:r:Glycerophospholipid catabolism", "R-SCE-9840310:r:Glycosphingolipid catabolism", "R-SCE-6814848:r:Glycerophospholipid catabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-SPO-196843:r:Vitamin B2 (riboflavin) metabolism"], "type": "Domain"}, "IPR002592": {"description": "Outer capsid protein sigma-1, C-terminal domain", "go_ids": ["GO:0019062", "GO:0007155", "GO:0019058"], "go_terms": ["GO:0019062:virion attachment to host cell:P", "GO:0007155:cell adhesion:P", "GO:0019058:viral life cycle:P"], "name": "S1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002593": {"description": "Domain of unknown function DX", "go_ids": [], "go_terms": [], "name": "DX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002594": {"description": "Glycoside hydrolase family 12", "go_ids": ["GO:0000272", "GO:0008810"], "go_terms": ["GO:0000272:polysaccharide catabolic process:P", "GO:0008810:cellulase activity:F"], "name": "GH12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002595": {"description": "African swine fever virus, MGF360", "go_ids": ["GO:0042330"], "go_terms": ["GO:0042330:taxis:P"], "name": "ASFV_MGF360", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002596": {"description": "Plasmid partition protein", "go_ids": [], "go_terms": [], "name": "Plasmid_parti", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002597": {"description": "Packaging protein UL32", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "UL32", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR002600": {"description": "Herpesvirus UL7-like", "go_ids": [], "go_terms": [], "name": "Herpes_UL7", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR002601": {"description": "C6 domain", "go_ids": [], "go_terms": [], "name": "C6_domain", "pathway_ids": ["R-CEL-6798695"], "pathways": ["R-CEL-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR002602": {"description": "Domain of unknown function DB", "go_ids": [], "go_terms": [], "name": "DB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002603": {"description": "ET repeat", "go_ids": [], "go_terms": [], "name": "ET_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR002605": {"description": "Adenovirus penton base protein", "go_ids": ["GO:0039623", "GO:0075509"], "go_terms": ["GO:0039623:T=25 icosahedral viral capsid:C", "GO:0075509:endocytosis involved in viral entry into host cell:P"], "name": "Adeno_Penton_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002606": {"description": "Riboflavin kinase, bacterial", "go_ids": ["GO:0003919", "GO:0008531", "GO:0009231"], "go_terms": ["GO:0003919:FMN adenylyltransferase activity:F", "GO:0008531:riboflavin kinase activity:F", "GO:0009231:riboflavin biosynthetic process:P"], "name": "Riboflavin_kinase_bac", "pathway_ids": ["PWY-7863", "PWY-6168", "PWY-5523", "PWY-6167"], "pathways": ["PWY-7863:t:roseoflavin biosynthesis", "PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-5523:t:5,6-dimethylbenzimidazole biosynthesis I (aerobic)", "PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Family"}, "IPR002608": {"description": "Paramyxovirus non-structural protein C", "go_ids": ["GO:0052031"], "go_terms": ["GO:0052031:symbiont-mediated perturbation of host defense response:P"], "name": "Paramyxo_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002610": {"description": "Peptidase S54, RHOMBOID-like", "go_ids": ["GO:0006508", "GO:0016020"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0016020:membrane:C"], "name": "Peptidase_S54_rhomboid-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002611": {"description": "IstB-like ATP-binding domain", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "IstB_ATP-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002612": {"description": "Adenovirus large t-antigen, E1B 55kDa protein", "go_ids": [], "go_terms": [], "name": "Adeno_E1B_55kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002614": {"description": "Inner layer core protein VP3, Orbivirus", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Inner_layer_core_VP3_Orbivir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002615": {"description": "Photosystem I PsaJ, reaction centre subunit IX", "go_ids": ["GO:0009522", "GO:0015979"], "go_terms": ["GO:0009522:photosystem I:C", "GO:0015979:photosynthesis:P"], "name": "PSI_PsaJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002616": {"description": "tRNA-guanine(15) transglycosylase-like", "go_ids": ["GO:0006400"], "go_terms": ["GO:0006400:tRNA modification:P"], "name": "tRNA_ribo_trans-like", "pathway_ids": ["PWY-6700", "PWY-8106", "R-HSA-6782315"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR002618": {"description": "UDPGP family", "go_ids": ["GO:0070569"], "go_terms": ["GO:0070569:uridylyltransferase activity:F"], "name": "UDPGP_fam", "pathway_ids": ["R-BTA-173599", "R-DDI-3322077", "R-SPO-173599", "R-SPO-3322077", "R-SCE-173599", "R-MMU-3322077", "R-HSA-3322077", "R-CEL-446210", "R-DDI-173599", "R-MMU-446210", "R-SCE-446210", "R-SCE-3322077", "R-SPO-446210", "R-BTA-3322077", "R-HSA-173599", "R-MMU-173599", "R-DDI-446210", "R-HSA-446210"], "pathways": ["R-BTA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DDI-3322077:r:Glycogen synthesis", "R-SPO-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-SPO-3322077:r:Glycogen synthesis", "R-SCE-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-3322077:r:Glycogen synthesis", "R-HSA-3322077:r:Glycogen synthesis", "R-CEL-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-DDI-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SCE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SCE-3322077:r:Glycogen synthesis", "R-SPO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-BTA-3322077:r:Glycogen synthesis", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DDI-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine"], "type": "Family"}, "IPR002619": {"description": "Domain of unknown function CX", "go_ids": [], "go_terms": [], "name": "CX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002620": {"description": "Alphavirus nsp2, protease domain", "go_ids": [], "go_terms": [], "name": "Alphavirus_nsp2pro", "pathway_ids": ["PWY-7045", "PWY-5381", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-7706", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-5316", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-7529", "PWY-8076", "PWY-5479", "PWY-6322", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-7342", "PWY-7904", "PWY-6736", "PWY-6998", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-7888", "PWY-5773", "PWY-7155", "PWY-7719", "PWY-7076", "PWY-7737", "PWY-8106", "PWY-6682", "PWY-8104", "PWY-7419", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-6545", "PWY-8379", "PWY-6749", "PWY-7668", "PWY-8179", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-7769", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-7127", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6626", "PWY-6286", "PWY-6581", "PWY-4202", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-7184", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-2681", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-7185", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7210", "PWY-7729", "PWY-7198", "PWY-7375", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-8117", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-7375:t:mRNA capping I", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR002621": {"description": "Geminivirus infecting protein", "go_ids": ["GO:0016020", "GO:0046740"], "go_terms": ["GO:0016020:membrane:C", "GO:0046740:transport of virus in host, cell to cell:P"], "name": "Gemini_mov", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002622": {"description": "Transposase, Synechocystis PCC 6803", "go_ids": [], "go_terms": [], "name": "Transposase_14", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002624": {"description": "Deoxynucleoside kinase", "go_ids": ["GO:0005524", "GO:0006139", "GO:0019136"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006139:nucleobase-containing compound metabolic process:P", "GO:0019136:deoxynucleoside kinase activity:F"], "name": "DCK/DGK", "pathway_ids": ["R-BTA-74217", "R-HSA-73614", "R-RNO-74217", "R-RNO-73614", "R-MMU-74217", "R-HSA-74217", "R-MMU-73614", "R-BTA-73614", "R-DME-73614"], "pathways": ["R-BTA-74217:r:Purine salvage", "R-HSA-73614:r:Pyrimidine salvage", "R-RNO-74217:r:Purine salvage", "R-RNO-73614:r:Pyrimidine salvage", "R-MMU-74217:r:Purine salvage", "R-HSA-74217:r:Purine salvage", "R-MMU-73614:r:Pyrimidine salvage", "R-BTA-73614:r:Pyrimidine salvage", "R-DME-73614:r:Pyrimidine salvage"], "type": "Family"}, "IPR002625": {"description": "Smr domain", "go_ids": [], "go_terms": [], "name": "Smr_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002628": {"description": "Photosystem II extrinsic protein O", "go_ids": ["GO:0010207", "GO:0009654", "GO:0042549", "GO:0010242"], "go_terms": ["GO:0010207:photosystem II assembly:P", "GO:0009654:photosystem II oxygen evolving complex:C", "GO:0042549:photosystem II stabilization:P", "GO:0010242:oxygen evolving activity:F"], "name": "PsbO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002629": {"description": "Cobalamin-independent methionine synthase MetE, C-terminal/archaeal", "go_ids": ["GO:0003871", "GO:0008270"], "go_terms": ["GO:0003871:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Met_Synth_C/arc", "pathway_ids": ["PWY-702", "PWY-6936", "PWY-6151", "PWY-5041"], "pathways": ["PWY-702:t:L-methionine biosynthesis II", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-6151:t:S-adenosyl-L-methionine salvage I", "PWY-5041:t:S-adenosyl-L-methionine salvage II"], "type": "Domain"}, "IPR002630": {"description": "Orbivirus non-structural protein NS1/hydrophobic tubular protein", "go_ids": [], "go_terms": [], "name": "Orbi_NS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002631": {"description": "Plasmid replication protein, origin binding domain", "go_ids": ["GO:0003677", "GO:0003916", "GO:0005727", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003916:DNA topoisomerase activity:F", "GO:0005727:extrachromosomal circular DNA:C", "GO:0006260:DNA replication:P"], "name": "Plasmid_rep_OBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002633": {"description": "Bacteriocin, class IIa", "go_ids": ["GO:0005576", "GO:0042742"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042742:defense response to bacterium:P"], "name": "Bacteriocin_IIa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002634": {"description": "BolA protein", "go_ids": [], "go_terms": [], "name": "BolA", "pathway_ids": ["R-HSA-8950505"], "pathways": ["R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "type": "Family"}, "IPR002635": {"description": "Chorion protein", "go_ids": ["GO:0005213", "GO:0007275", "GO:0007304", "GO:0042600"], "go_terms": ["GO:0005213:structural constituent of egg chorion:F", "GO:0007275:multicellular organism development:P", "GO:0007304:chorion-containing eggshell formation:P", "GO:0042600:egg chorion:C"], "name": "Chorion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002636": {"description": "Protein from unkown function DUF29", "go_ids": [], "go_terms": [], "name": "DUF29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002637": {"description": "RdgB/HAM1", "go_ids": ["GO:0009143", "GO:0047429"], "go_terms": ["GO:0009143:nucleoside triphosphate catabolic process:P", "GO:0047429:nucleoside triphosphate diphosphatase activity:F"], "name": "RdgB/HAM1", "pathway_ids": ["R-GGA-74259", "R-DDI-9755088", "R-SCE-9755088", "R-CEL-74259", "R-RNO-9755088", "R-RNO-74259", "R-PFA-9755088", "R-GGA-9755088", "R-CEL-9755088", "R-MMU-9755088", "R-BTA-9755088", "R-BTA-74259", "R-HSA-74259", "R-DME-74259", "R-DRE-74259", "R-SPO-9755088", "R-DRE-9755088", "R-MMU-74259", "R-SCE-74259", "R-DME-9755088", "R-SPO-74259", "R-HSA-9755088", "R-PFA-74259", "R-DDI-74259"], "pathways": ["R-GGA-74259:r:Purine catabolism", "R-DDI-9755088:r:Ribavirin ADME", "R-SCE-9755088:r:Ribavirin ADME", "R-CEL-74259:r:Purine catabolism", "R-RNO-9755088:r:Ribavirin ADME", "R-RNO-74259:r:Purine catabolism", "R-PFA-9755088:r:Ribavirin ADME", "R-GGA-9755088:r:Ribavirin ADME", "R-CEL-9755088:r:Ribavirin ADME", "R-MMU-9755088:r:Ribavirin ADME", "R-BTA-9755088:r:Ribavirin ADME", "R-BTA-74259:r:Purine catabolism", "R-HSA-74259:r:Purine catabolism", "R-DME-74259:r:Purine catabolism", "R-DRE-74259:r:Purine catabolism", "R-SPO-9755088:r:Ribavirin ADME", "R-DRE-9755088:r:Ribavirin ADME", "R-MMU-74259:r:Purine catabolism", "R-SCE-74259:r:Purine catabolism", "R-DME-9755088:r:Ribavirin ADME", "R-SPO-74259:r:Purine catabolism", "R-HSA-9755088:r:Ribavirin ADME", "R-PFA-74259:r:Purine catabolism", "R-DDI-74259:r:Purine catabolism"], "type": "Family"}, "IPR002638": {"description": "Quinolinate phosphoribosyl transferase, C-terminal", "go_ids": ["GO:0004514", "GO:0009435"], "go_terms": ["GO:0004514:nicotinate-nucleotide diphosphorylase (carboxylating) activity:F", "GO:0009435:NAD+ biosynthetic process:P"], "name": "Quinolinate_PRibosylTrfase_C", "pathway_ids": ["PWY-7342", "PWY-8277", "PWY-5653", "PWY-5316", "PWY-8352", "R-MMU-196807", "R-HSA-196807", "R-DDI-196807", "R-RNO-196807", "R-SSC-196807", "R-SCE-196807"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-8277:t:NAD de novo biosynthesis IV (anaerobic)", "PWY-5653:t:NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde", "PWY-5316:t:nicotine biosynthesis", "PWY-8352:t:NAD de novo biosynthesis III", "R-MMU-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-SSC-196807:r:Nicotinate metabolism", "R-SCE-196807:r:Nicotinate metabolism"], "type": "Domain"}, "IPR002639": {"description": "Urease accessory protein UreF", "go_ids": ["GO:0016151"], "go_terms": ["GO:0016151:nickel cation binding:F"], "name": "UreF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002640": {"description": "Arylesterase-like", "go_ids": ["GO:0004064"], "go_terms": ["GO:0004064:arylesterase activity:F"], "name": "Arylesterase-like", "pathway_ids": ["PWY-5489", "PWY-8065", "PWY-5490", "R-HSA-9754706", "R-CEL-9754706", "R-MMU-9754706", "R-RNO-9754706", "R-MMU-2142688", "R-CEL-2142688", "R-RNO-2142688", "R-HSA-2142688", "R-BTA-2142688"], "pathways": ["PWY-5489:t:methyl parathion degradation", "PWY-8065:t:chlorpyrifos degradation", "PWY-5490:t:paraoxon degradation", "R-HSA-9754706:r:Atorvastatin ADME", "R-CEL-9754706:r:Atorvastatin ADME", "R-MMU-9754706:r:Atorvastatin ADME", "R-RNO-9754706:r:Atorvastatin ADME", "R-MMU-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-CEL-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-RNO-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-HSA-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-BTA-2142688:r:Synthesis of 5-eicosatetraenoic acids"], "type": "Family"}, "IPR002641": {"description": "Patatin-like phospholipase domain", "go_ids": ["GO:0006629"], "go_terms": ["GO:0006629:lipid metabolic process:P"], "name": "PNPLA_dom", "pathway_ids": ["R-CEL-163560", "R-HSA-6814848", "R-MMU-6814848", "R-CEL-6814848", "R-HSA-2029485", "R-DME-6814848", "R-RNO-1482883", "R-MMU-1482839", "R-MMU-8957275", "R-HSA-1482798", "R-HSA-163560", "R-HSA-9841922", "R-MMU-6811436", "R-RNO-381426", "R-RNO-6811436", "R-RNO-1482788", "R-HSA-381426", "R-MMU-1482883", "R-RNO-2029485", "R-RNO-8957275", "R-MMU-381426", "R-CEL-8957275", "R-HSA-1482839", "R-MMU-1482788", "R-CEL-381426", "R-MMU-163560", "R-MMU-2029485", "R-HSA-1482883", "R-CEL-1482883", "R-HSA-8957275", "R-SPO-6814848", "R-RNO-1482839", "R-SCE-6814848", "R-HSA-6811436", "R-HSA-1482788"], "pathways": ["R-CEL-163560:r:Triglyceride catabolism", "R-HSA-6814848:r:Glycerophospholipid catabolism", "R-MMU-6814848:r:Glycerophospholipid catabolism", "R-CEL-6814848:r:Glycerophospholipid catabolism", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-6814848:r:Glycerophospholipid catabolism", "R-RNO-1482883:r:Acyl chain remodeling of DAG and TAG", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-HSA-163560:r:Triglyceride catabolism", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1482883:r:Acyl chain remodeling of DAG and TAG", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-163560:r:Triglyceride catabolism", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1482883:r:Acyl chain remodeling of DAG and TAG", "R-CEL-1482883:r:Acyl chain remodeling of DAG and TAG", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SPO-6814848:r:Glycerophospholipid catabolism", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-SCE-6814848:r:Glycerophospholipid catabolism", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Domain"}, "IPR002642": {"description": "Lysophospholipase, catalytic domain", "go_ids": ["GO:0004620", "GO:0009395"], "go_terms": ["GO:0004620:glycerophospholipase activity:F", "GO:0009395:phospholipid catabolic process:P"], "name": "LysoPLipase_cat_dom", "pathway_ids": ["PWY-7409", "R-RNO-418592", "R-BTA-1483115", "R-XTR-1482801", "R-SPO-1482925", "R-RNO-111995", "R-SPO-2142753", "R-SPO-1482839", "R-XTR-1483115", "R-SPO-1483152", "R-MMU-1482788", "R-SCE-111995", "R-SPO-111995", "R-HSA-418592", "R-BTA-1482839", "R-GGA-1483115", "R-MMU-1482839", "R-GGA-1483166", "R-RNO-6811436", "R-XTR-1482798", "R-MMU-1483166", "R-DRE-1483166", "R-BTA-6811436", "R-HSA-1482839", "R-BTA-2142753", "R-XTR-2142753", "R-SPO-432142", "R-SPO-1482801", "R-HSA-1483152", "R-HSA-1482788", "R-SCE-418592", "R-SCE-2142753", "R-GGA-1482788", "R-MMU-2142753", "R-XTR-432142", "R-SCE-1482925", "R-GGA-1482798", "R-GGA-1482925", "R-HSA-1483166", "R-HSA-1482925", "R-SCE-6811436", "R-GGA-111995", "R-DRE-1483115", "R-BTA-1483166", "R-RNO-1482925", "R-HSA-1483115", "R-HSA-6811436", "R-HSA-381038", "R-DRE-111995", "R-SCE-1483115", "R-HSA-1482798", "R-HSA-1482801", "R-SCE-1482801", "R-SPO-1482922", "R-BTA-1482922", "R-SCE-1483166", "R-DRE-418592", "R-XTR-1482925", "R-XTR-6811436", "R-RNO-1482798", "R-MMU-111995", "R-SPO-418592", "R-SCE-1482798", "R-GGA-1482839", "R-RNO-1483166", "R-XTR-418592", "R-HSA-432142", "R-BTA-1482801", "R-MMU-432142", "R-RNO-1482788", "R-SPO-1482798", "R-SCE-1482839", "R-MMU-1482798", "R-BTA-1482798", "R-SCE-1482922", "R-RNO-1482839", "R-GGA-1482922", "R-RNO-1482801", "R-MMU-1483152", "R-SCE-432142", "R-DRE-1482798", "R-DRE-432142", "R-BTA-432142", "R-RNO-1483115", "R-RNO-1482922", "R-BTA-1482925", "R-DRE-1482925", "R-DRE-1482788", "R-SPO-6811436", "R-BTA-111995", "R-SPO-1483115", "R-MMU-6811436", "R-BTA-418592", "R-SCE-1482788", "R-RNO-432142", "R-GGA-1482801", "R-XTR-1482922", "R-GGA-418592", "R-BTA-1482788", "R-XTR-1483166", "R-MMU-1483115", "R-HSA-1482922", "R-SPO-1483166", "R-DRE-1482839", "R-DRE-2142753", "R-MMU-1482925", "R-XTR-1482839", "R-SCE-1483152", "R-GGA-6811436", "R-RNO-2142753", "R-XTR-111995", "R-HSA-2142753", "R-DRE-1482922", "R-GGA-432142", "R-MMU-418592", "R-HSA-111995", "R-XTR-1482788", "R-MMU-1482922", "R-SPO-1482788", "R-GGA-2142753", "R-DRE-1482801", "R-MMU-1482801", "R-DRE-6811436"], "pathways": ["PWY-7409:t:phospholipid remodeling (phosphatidylethanolamine, yeast)", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-1483115:r:Hydrolysis of LPC", "R-XTR-1482801:r:Acyl chain remodelling of PS", "R-SPO-1482925:r:Acyl chain remodelling of PG", "R-RNO-111995:r:phospho-PLA2 pathway", "R-SPO-2142753:r:Arachidonate metabolism", "R-SPO-1482839:r:Acyl chain remodelling of PE", "R-XTR-1483115:r:Hydrolysis of LPC", "R-SPO-1483152:r:Hydrolysis of LPE", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-SCE-111995:r:phospho-PLA2 pathway", "R-SPO-111995:r:phospho-PLA2 pathway", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-GGA-1483115:r:Hydrolysis of LPC", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-GGA-1483166:r:Synthesis of PA", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-XTR-1482798:r:Acyl chain remodeling of CL", "R-MMU-1483166:r:Synthesis of PA", "R-DRE-1483166:r:Synthesis of PA", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-BTA-2142753:r:Arachidonate metabolism", "R-XTR-2142753:r:Arachidonate metabolism", "R-SPO-432142:r:Platelet sensitization by LDL", "R-SPO-1482801:r:Acyl chain remodelling of PS", "R-HSA-1483152:r:Hydrolysis of LPE", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-SCE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SCE-2142753:r:Arachidonate metabolism", "R-GGA-1482788:r:Acyl chain remodelling of PC", "R-MMU-2142753:r:Arachidonate metabolism", "R-XTR-432142:r:Platelet sensitization by LDL", "R-SCE-1482925:r:Acyl chain remodelling of PG", "R-GGA-1482798:r:Acyl chain remodeling of CL", "R-GGA-1482925:r:Acyl chain remodelling of PG", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-SCE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-GGA-111995:r:phospho-PLA2 pathway", "R-DRE-1483115:r:Hydrolysis of LPC", "R-BTA-1483166:r:Synthesis of PA", "R-RNO-1482925:r:Acyl chain remodelling of PG", "R-HSA-1483115:r:Hydrolysis of LPC", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DRE-111995:r:phospho-PLA2 pathway", "R-SCE-1483115:r:Hydrolysis of LPC", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-SCE-1482801:r:Acyl chain remodelling of PS", "R-SPO-1482922:r:Acyl chain remodelling of PI", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-SCE-1483166:r:Synthesis of PA", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-XTR-1482925:r:Acyl chain remodelling of PG", "R-XTR-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-1482798:r:Acyl chain remodeling of CL", "R-MMU-111995:r:phospho-PLA2 pathway", "R-SPO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SCE-1482798:r:Acyl chain remodeling of CL", "R-GGA-1482839:r:Acyl chain remodelling of PE", "R-RNO-1483166:r:Synthesis of PA", "R-XTR-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-432142:r:Platelet sensitization by LDL", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-SPO-1482798:r:Acyl chain remodeling of CL", "R-SCE-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-BTA-1482798:r:Acyl chain remodeling of CL", "R-SCE-1482922:r:Acyl chain remodelling of PI", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-GGA-1482922:r:Acyl chain remodelling of PI", "R-RNO-1482801:r:Acyl chain remodelling of PS", "R-MMU-1483152:r:Hydrolysis of LPE", "R-SCE-432142:r:Platelet sensitization by LDL", "R-DRE-1482798:r:Acyl chain remodeling of CL", "R-DRE-432142:r:Platelet sensitization by LDL", "R-BTA-432142:r:Platelet sensitization by LDL", "R-RNO-1483115:r:Hydrolysis of LPC", "R-RNO-1482922:r:Acyl chain remodelling of PI", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-DRE-1482925:r:Acyl chain remodelling of PG", "R-DRE-1482788:r:Acyl chain remodelling of PC", "R-SPO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-111995:r:phospho-PLA2 pathway", "R-SPO-1483115:r:Hydrolysis of LPC", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SCE-1482788:r:Acyl chain remodelling of PC", "R-RNO-432142:r:Platelet sensitization by LDL", "R-GGA-1482801:r:Acyl chain remodelling of PS", "R-XTR-1482922:r:Acyl chain remodelling of PI", "R-GGA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-XTR-1483166:r:Synthesis of PA", "R-MMU-1483115:r:Hydrolysis of LPC", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-SPO-1483166:r:Synthesis of PA", "R-DRE-1482839:r:Acyl chain remodelling of PE", "R-DRE-2142753:r:Arachidonate metabolism", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-XTR-1482839:r:Acyl chain remodelling of PE", "R-SCE-1483152:r:Hydrolysis of LPE", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-2142753:r:Arachidonate metabolism", "R-XTR-111995:r:phospho-PLA2 pathway", "R-HSA-2142753:r:Arachidonate metabolism", "R-DRE-1482922:r:Acyl chain remodelling of PI", "R-GGA-432142:r:Platelet sensitization by LDL", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-111995:r:phospho-PLA2 pathway", "R-XTR-1482788:r:Acyl chain remodelling of PC", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-SPO-1482788:r:Acyl chain remodelling of PC", "R-GGA-2142753:r:Arachidonate metabolism", "R-DRE-1482801:r:Acyl chain remodelling of PS", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR002643": {"description": "Polyomavirus agnoprotein", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Polyoma_agno", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002644": {"description": "Photosystem II PsbZ, reaction centre", "go_ids": ["GO:0009539", "GO:0042549", "GO:0009523", "GO:0015979"], "go_terms": ["GO:0009539:photosystem II reaction center:C", "GO:0042549:photosystem II stabilization:P", "GO:0009523:photosystem II:C", "GO:0015979:photosynthesis:P"], "name": "PSII_PsbZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002645": {"description": "STAS domain", "go_ids": [], "go_terms": [], "name": "STAS_dom", "pathway_ids": ["R-SCE-427601", "R-CEL-427601", "R-HSA-3560792", "R-SPO-427601", "R-BTA-174362", "R-SCE-174362", "R-HSA-5619085", "R-HSA-9662361", "R-BTA-427601", "R-HSA-5619046", "R-RNO-427601", "R-SPO-174362", "R-CEL-174362", "R-HSA-427601", "R-DRE-427601", "R-MMU-174362", "R-HSA-174362", "R-MMU-427601", "R-RNO-174362"], "pathways": ["R-SCE-427601:r:Inorganic anion exchange by SLC26 transporters", "R-CEL-427601:r:Inorganic anion exchange by SLC26 transporters", "R-HSA-3560792:r:Defective SLC26A2 causes chondrodysplasias", "R-SPO-427601:r:Inorganic anion exchange by SLC26 transporters", "R-BTA-174362:r:Transport and metabolism of PAPS", "R-SCE-174362:r:Transport and metabolism of PAPS", "R-HSA-5619085:r:Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-BTA-427601:r:Inorganic anion exchange by SLC26 transporters", "R-HSA-5619046:r:Defective SLC26A4 causes Pendred syndrome (PDS)", "R-RNO-427601:r:Inorganic anion exchange by SLC26 transporters", "R-SPO-174362:r:Transport and metabolism of PAPS", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-HSA-427601:r:Inorganic anion exchange by SLC26 transporters", "R-DRE-427601:r:Inorganic anion exchange by SLC26 transporters", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-MMU-427601:r:Inorganic anion exchange by SLC26 transporters", "R-RNO-174362:r:Transport and metabolism of PAPS"], "type": "Domain"}, "IPR002646": {"description": "Poly A polymerase, head domain", "go_ids": ["GO:0003723", "GO:0006396", "GO:0016779"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006396:RNA processing:P", "GO:0016779:nucleotidyltransferase activity:F"], "name": "PolA_pol_head_dom", "pathway_ids": ["R-HSA-6785470", "R-HSA-6784531"], "pathways": ["R-HSA-6785470:r:tRNA processing in the mitochondrion", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR002648": {"description": "Adenylate dimethylallyltransferase", "go_ids": ["GO:0009691", "GO:0009824"], "go_terms": ["GO:0009691:cytokinin biosynthetic process:P", "GO:0009824:AMP dimethylallyltransferase activity:F"], "name": "Tzs", "pathway_ids": ["PWY-2681"], "pathways": ["PWY-2681:t:trans-zeatin biosynthesis"], "type": "Family"}, "IPR002649": {"description": "tRNA (guanine-N1-)-methyltransferase TrmD", "go_ids": ["GO:0008033", "GO:0052906"], "go_terms": ["GO:0008033:tRNA processing:P", "GO:0052906:tRNA (guanine(37)-N1)-methyltransferase activity:F"], "name": "tRNA_m1G_MeTrfase_TrmD", "pathway_ids": ["PWY-7286", "PWY-7285", "PWY-6829"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-6829:t:tRNA methylation (yeast)"], "type": "Family"}, "IPR002650": {"description": "Sulphate adenylyltransferase", "go_ids": ["GO:0000103", "GO:0004781"], "go_terms": ["GO:0000103:sulfate assimilation:P", "GO:0004781:sulfate adenylyltransferase (ATP) activity:F"], "name": "Sulphate_adenylyltransferase", "pathway_ids": ["PWY-6683", "PWY-5278", "PWY-6932", "PWY-5340", "R-MMU-174362", "R-HSA-174362", "R-HSA-2408550", "R-CEL-174362", "R-HSA-6802952", "R-HSA-3560796"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III", "PWY-5278:t:sulfite oxidation III", "PWY-6932:t:selenate reduction", "PWY-5340:t:sulfate activation for sulfonation", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-3560796:r:Defective PAPSS2 causes SEMD-PA"], "type": "Family"}, "IPR002652": {"description": "Importin-alpha, importin-beta-binding domain", "go_ids": ["GO:0006606", "GO:0061608"], "go_terms": ["GO:0006606:protein import into nucleus:P", "GO:0061608:nuclear import signal receptor activity:F"], "name": "Importin-a_IBB", "pathway_ids": ["R-HSA-140342", "R-BTA-191859", "R-HSA-180910", "R-HSA-9636249", "R-SPO-68616", "R-HSA-442729", "R-HSA-191859", "R-HSA-168276", "R-BTA-68616", "R-BTA-140342", "R-HSA-9705671", "R-MMU-5693548", "R-HSA-9918432", "R-HSA-168271", "R-DDI-909733", "R-GGA-191859", "R-HSA-1169408", "R-RNO-140342", "R-CEL-909733", "R-HSA-68616", "R-MMU-140342", "R-HSA-162592", "R-RNO-68616", "R-HSA-909733", "R-BTA-909733", "R-RNO-909733", "R-RNO-191859", "R-HSA-9692916", "R-MMU-68616", "R-HSA-111932", "R-DME-5693548", "R-HSA-5693548", "R-MMU-909733", "R-MMU-191859", "R-HSA-9018519"], "pathways": ["R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-BTA-191859:r:snRNP Assembly", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-191859:r:snRNP Assembly", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-GGA-191859:r:snRNP Assembly", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-162592:r:Integration of provirus", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-RNO-191859:r:snRNP Assembly", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-191859:r:snRNP Assembly", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR002653": {"description": "Zinc finger, A20-type", "go_ids": ["GO:0003677", "GO:0008270"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008270:zinc ion binding:F"], "name": "Znf_A20", "pathway_ids": ["R-MMU-5357786", "R-HSA-168638", "R-HSA-8854214", "R-HSA-5689896", "R-HSA-936440", "R-HSA-8876198", "R-MMU-9033241", "R-MMU-5357956", "R-MMU-5689896", "R-HSA-5357786", "R-BTA-9033241", "R-RNO-9033241", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-8876198", "R-MMU-5357905", "R-MMU-936440", "R-MMU-168638", "R-HSA-9033241"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR002654": {"description": "Glycosyl transferase, family 25", "go_ids": [], "go_terms": [], "name": "Glyco_trans_25", "pathway_ids": ["R-DRE-1650814", "R-DME-1650814", "R-MMU-1650814", "R-HSA-1650814", "R-BTA-1650814"], "pathways": ["R-DRE-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes"], "type": "Domain"}, "IPR002655": {"description": "Acyl-CoA oxidase, C-terminal", "go_ids": ["GO:0003997", "GO:0005777", "GO:0006635"], "go_terms": ["GO:0003997:acyl-CoA oxidase activity:F", "GO:0005777:peroxisome:C", "GO:0006635:fatty acid beta-oxidation:P"], "name": "Acyl-CoA_oxidase_C", "pathway_ids": ["PWY-7858", "PWY-7291", "PWY-7288", "PWY-6920", "PWY-7007", "PWY-7574", "PWY-735", "PWY-7854", "PWY-6837", "PWY-5136", "PWY-7337", "PWY-7338", "PWY-7340", "PWY-7606", "PWY-7726", "R-HSA-1989781", "R-MMU-2046106", "R-MMU-193368", "R-DDI-390247", "R-DDI-2046106", "R-DME-9033241", "R-DME-389887", "R-RNO-2046106", "R-HSA-389887", "R-HSA-193368", "R-BTA-2046106", "R-DME-2046106", "R-MMU-9033241", "R-CEL-390247", "R-BTA-9033241", "R-CEL-2046106", "R-CEL-193368", "R-RNO-9033241", "R-MMU-389887", "R-SCE-389887", "R-DME-193368", "R-RNO-389887", "R-DDI-389887", "R-DDI-193368", "R-HSA-390247", "R-MMU-390247", "R-RNO-193368", "R-BTA-390247", "R-CEL-389887", "R-HSA-9033500", "R-HSA-2046106", "R-DME-390247", "R-DDI-9033241", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-7291:t:oleate beta-oxidation (isomerase-dependent, yeast)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7574:t:propanoyl-CoA degradation II", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-6837:t:fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-9033241:r:Peroxisomal protein import", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-CEL-390247:r:Beta-oxidation of very long chain fatty acids", "R-BTA-9033241:r:Peroxisomal protein import", "R-CEL-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-CEL-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR002656": {"description": "Acyltransferase 3 domain", "go_ids": ["GO:0016747"], "go_terms": ["GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "Acyl_transf_3_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002657": {"description": "Bile acid:sodium symporter/arsenical resistance protein Acr3", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "BilAc:Na_symport/Acr3", "pathway_ids": ["R-HSA-159418", "R-RNO-9958517", "R-MMU-9958517", "R-RNO-159418", "R-MMU-159418", "R-HSA-9958517"], "pathways": ["R-HSA-159418:r:Recycling of bile acids and salts", "R-RNO-9958517:r:SLC-mediated bile acid transport", "R-MMU-9958517:r:SLC-mediated bile acid transport", "R-RNO-159418:r:Recycling of bile acids and salts", "R-MMU-159418:r:Recycling of bile acids and salts", "R-HSA-9958517:r:SLC-mediated bile acid transport"], "type": "Family"}, "IPR002659": {"description": "Glycosyl transferase, family 31", "go_ids": ["GO:0016020", "GO:0009101", "GO:0016758"], "go_terms": ["GO:0016020:membrane:C", "GO:0009101:glycoprotein biosynthetic process:P", "GO:0016758:hexosyltransferase activity:F"], "name": "Glyco_trans_31", "pathway_ids": ["R-DRE-913709", "R-RNO-9037629", "R-MMU-913709", "R-CEL-9840309", "R-DRE-9840309", "R-MMU-9931295", "R-XTR-9840309", "R-XTR-8932505", "R-HSA-9037629", "R-DME-2022854", "R-DME-9037629", "R-RNO-913709", "R-BTA-913709", "R-SSC-913709", "R-HSA-9931295", "R-MMU-8932505", "R-HSA-8932505", "R-HSA-1971475", "R-MMU-2022854", "R-DME-9840309", "R-HSA-9840309", "R-HSA-2022854", "R-CFA-9840309", "R-CEL-1971475", "R-RNO-9840309", "R-SSC-9840309", "R-CFA-9037629", "R-MMU-9840309", "R-RNO-2022854", "R-XTR-913709", "R-HSA-4420332", "R-CEL-913709", "R-DME-913709", "R-MMU-1971475", "R-CEL-9037629", "R-MMU-9037629", "R-HSA-913709", "R-DRE-8932505"], "pathways": ["R-DRE-913709:r:O-linked glycosylation of mucins", "R-RNO-9037629:r:Lewis blood group biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-CEL-9840309:r:Glycosphingolipid biosynthesis", "R-DRE-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-XTR-9840309:r:Glycosphingolipid biosynthesis", "R-XTR-8932505:r:DAG1 core M3 glycosylations", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-DME-2022854:r:Keratan sulfate biosynthesis", "R-DME-9037629:r:Lewis blood group biosynthesis", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-BTA-913709:r:O-linked glycosylation of mucins", "R-SSC-913709:r:O-linked glycosylation of mucins", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-DME-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-CFA-9840309:r:Glycosphingolipid biosynthesis", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-SSC-9840309:r:Glycosphingolipid biosynthesis", "R-CFA-9037629:r:Lewis blood group biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-XTR-913709:r:O-linked glycosylation of mucins", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-DME-913709:r:O-linked glycosylation of mucins", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-9037629:r:Lewis blood group biosynthesis", "R-MMU-9037629:r:Lewis blood group biosynthesis", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-DRE-8932505:r:DAG1 core M3 glycosylations"], "type": "Family"}, "IPR002660": {"description": "Herpesvirus portal protein", "go_ids": ["GO:0051276"], "go_terms": ["GO:0051276:chromosome organization:P"], "name": "Herpes_Portal", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR002661": {"description": "Ribosome recycling factor", "go_ids": ["GO:0006412"], "go_terms": ["GO:0006412:translation:P"], "name": "Ribosome_recyc_fac", "pathway_ids": ["R-RNO-5419276", "R-CEL-5419276", "R-MMU-5419276", "R-HSA-5419276"], "pathways": ["R-RNO-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR002662": {"description": "Birnavirus VP2 protein", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Birna_VP2", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR002663": {"description": "Birnavirus VP3 protein", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Birna_VP3", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR002666": {"description": "Reduced folate carrier", "go_ids": ["GO:0090482", "GO:0051180", "GO:0016020"], "go_terms": ["GO:0090482:vitamin transmembrane transporter activity:F", "GO:0051180:vitamin transport:P", "GO:0016020:membrane:C"], "name": "Folate_carrier", "pathway_ids": ["R-DDI-196819", "R-MMU-196757", "R-CEL-196819", "R-RNO-196757", "R-DDI-196757", "R-HSA-196757", "R-HSA-196819", "R-MMU-196819", "R-CEL-196757"], "pathways": ["R-DDI-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196757:r:Metabolism of folate and pterines", "R-CEL-196819:r:Vitamin B1 (thiamin) metabolism", "R-RNO-196757:r:Metabolism of folate and pterines", "R-DDI-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Family"}, "IPR002668": {"description": "Concentrative nucleoside transporter N-terminal domain", "go_ids": [], "go_terms": [], "name": "CNT_N_dom", "pathway_ids": ["R-MMU-9748787", "R-MMU-9755088", "R-RNO-83936", "R-HSA-9748787", "R-HSA-83936", "R-RNO-9748787", "R-RNO-9755088", "R-HSA-9755088", "R-MMU-83936"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-MMU-9755088:r:Ribavirin ADME", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-9748787:r:Azathioprine ADME", "R-RNO-9755088:r:Ribavirin ADME", "R-HSA-9755088:r:Ribavirin ADME", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "type": "Domain"}, "IPR002669": {"description": "Urease accessory protein UreD", "go_ids": ["GO:0016151"], "go_terms": ["GO:0016151:nickel cation binding:F"], "name": "UreD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002671": {"description": "Large ribosomal subunit protein eL22", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL22", "pathway_ids": ["R-XTR-6791226", "R-CEL-975957", "R-HSA-9010553", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-XTR-9954716", "R-CEL-72706", "R-XTR-1799339", "R-GGA-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-RNO-156827", "R-MMU-9954714", "R-XTR-9954714", "R-SSC-9954714", "R-CEL-1799339", "R-HSA-72706", "R-GGA-9954716", "R-CEL-156827", "R-RNO-6791226", "R-SSC-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SSC-72689", "R-XTR-72706", "R-HSA-9954714", "R-CEL-72689", "R-MMU-1799339", "R-GGA-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-72689", "R-XTR-975956", "R-HSA-156827", "R-XTR-9954709", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-XTR-975957", "R-SSC-156827", "R-HSA-9954709", "R-DME-1799339", "R-GGA-9954714", "R-MMU-975956", "R-DME-975956", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-XTR-156827", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SSC-9954709", "R-MMU-156827", "R-GGA-9954709", "R-GGA-975957", "R-HSA-975957", "R-DME-9954714", "R-SSC-6791226", "R-GGA-1799339", "R-DME-975957", "R-SSC-9954716", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-XTR-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-XTR-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-XTR-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-XTR-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", 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"R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR002675": {"description": "Large ribosomal subunit protein eL38", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL38", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-SPO-9954709", "R-SPO-975956", "R-RNO-156827", "R-MMU-9954714", "R-BTA-6791226", "R-SPO-72706", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-DDI-72689", "R-MMU-1799339", "R-SPO-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-DME-1799339", "R-SCE-1799339", "R-SPO-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 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membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated 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Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR002676": {"description": "RimM, N-terminal", "go_ids": ["GO:0006364"], "go_terms": ["GO:0006364:rRNA processing:P"], "name": "RimM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002677": {"description": "Large ribosomal subunit protein bL32", "go_ids": ["GO:0003735", "GO:0006412", "GO:0015934"], "go_terms": ["GO:0003735:structural constituent of 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quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR002678": {"description": "DUF34/NIF3", "go_ids": [], "go_terms": [], "name": "DUF34/NIF3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002679": {"description": "Closterovirus coat protein", "go_ids": ["GO:0044423"], "go_terms": ["GO:0044423:virion component:C"], "name": "Closter_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002680": {"description": "Alternative oxidase", "go_ids": ["GO:0009916"], "go_terms": ["GO:0009916:alternative oxidase activity:F"], "name": "AOX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002681": {"description": "Coat protein, Ilarvirus", "go_ids": ["GO:0003723", "GO:0006413", "GO:0044423"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006413:translational initiation:P", "GO:0044423:virion component:C"], "name": "Coat_Ilarvirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002682": {"description": "Photosystem II PsbJ", "go_ids": ["GO:0009539", "GO:0015979", "GO:0016020", "GO:0009523"], "go_terms": ["GO:0009539:photosystem II reaction center:C", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C", "GO:0009523:photosystem II:C"], "name": "PSII_PsbJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002683": {"description": "PsbP, C-terminal", "go_ids": ["GO:0005509", "GO:0009654", "GO:0015979", "GO:0019898", "GO:0009523"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0009654:photosystem II oxygen evolving complex:C", "GO:0015979:photosynthesis:P", "GO:0019898:extrinsic component of membrane:C", "GO:0009523:photosystem II:C"], "name": "PsbP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002684": {"description": "Biotin synthase/Biotin biosynthesis bifunctional protein BioAB-like", "go_ids": [], "go_terms": [], "name": "Biotin_synth/BioAB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002685": {"description": "Glycosyl transferase, family 15", "go_ids": ["GO:0016020", "GO:0009101", "GO:0000030"], "go_terms": ["GO:0016020:membrane:C", "GO:0009101:glycoprotein biosynthetic process:P", "GO:0000030:mannosyltransferase activity:F"], "name": "Glyco_trans_15", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR002686": {"description": "Transposase IS200-like", "go_ids": ["GO:0003677", "GO:0004803", "GO:0006313"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004803:transposase activity:F", "GO:0006313:DNA transposition:P"], "name": "Transposase_17", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002687": {"description": "Nop domain", "go_ids": [], "go_terms": [], "name": "Nop_dom", "pathway_ids": ["R-MMU-6791226", "R-SCE-4570464", "R-HSA-390471", "R-MMU-72163", "R-DDI-6791226", "R-DDI-4570464", "R-MMU-4570464", "R-HSA-6790901", "R-RNO-6791226", "R-HSA-72163", "R-SPO-4570464", "R-SCE-6791226", "R-HSA-6791226", "R-RNO-4570464", "R-HSA-4570464", "R-CEL-6791226", "R-SPO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR002689": {"description": "Cytomegalovirus glycoprotein L", "go_ids": ["GO:0016032", "GO:0019031"], "go_terms": ["GO:0016032:viral process:P", "GO:0019031:viral envelope:C"], "name": "Cytomegalo_gL", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR002690": {"description": "Herpesvirus capsid protein 2", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Herpes_capsid_2", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR002692": {"description": "Penicillin/GL-7-ACA/AHL/aculeacin-A acylase", "go_ids": ["GO:0016787", "GO:0017000"], "go_terms": ["GO:0016787:hydrolase activity:F", "GO:0017000:antibiotic biosynthetic process:P"], "name": "S45", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002693": {"description": "Paramyxovirinae P phosphoprotein, C-terminal domain", "go_ids": ["GO:0003723", "GO:0003968", "GO:0006351", "GO:0019079"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P", "GO:0019079:viral genome replication:P"], "name": "Paramyxo_PProtein_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002694": {"description": "Zinc finger, CHC2-type", "go_ids": ["GO:0003677", "GO:0006260", "GO:0008270", "GO:0003899"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006260:DNA replication:P", "GO:0008270:zinc ion binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F"], "name": "Znf_CHC2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002695": {"description": "Bifunctional purine biosynthesis protein PurH-like", "go_ids": ["GO:0003937", "GO:0004643", "GO:0006164"], "go_terms": ["GO:0003937:IMP cyclohydrolase activity:F", "GO:0004643:phosphoribosylaminoimidazolecarboxamide formyltransferase activity:F", "GO:0006164:purine nucleotide biosynthetic process:P"], "name": "PurH-like", "pathway_ids": ["PWY-6123", "PWY-7234", "PWY-6124", "R-SPO-73817", "R-DDI-73817", "R-RNO-73817", "R-SCE-73817", "R-BTA-73817", "R-HSA-73817", "R-MMU-73817", "R-HSA-9725370", "R-GGA-419140"], "pathways": ["PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-7234:t:inosine-5'-phosphate biosynthesis III", "PWY-6124:t:inosine-5'-phosphate biosynthesis II", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Family"}, "IPR002696": {"description": "Membrane protein insertion efficiency factor YidD-like", "go_ids": [], "go_terms": [], "name": "Membr_insert_effic_factor_YidD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002698": {"description": "5-formyltetrahydrofolate cyclo-ligase", "go_ids": [], "go_terms": [], "name": "FTHF_cligase", "pathway_ids": ["R-SCE-196757", "R-SPO-196757", "R-HSA-196757", "R-MMU-196757", "R-CEL-196757"], "pathways": ["R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Family"}, "IPR002699": {"description": "ATPase, V1 complex, subunit D", "go_ids": ["GO:0046961"], "go_terms": ["GO:0046961:proton-transporting ATPase activity, rotational mechanism:F"], "name": "V_ATPase_D", "pathway_ids": ["R-HSA-6798695", "R-CEL-1222556", "R-SPO-6798695", "R-MMU-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-CEL-6798695", "R-SCE-6798695", "R-MMU-9639288", "R-SPO-9639288", "R-HSA-9639288", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-DDI-6798695", "R-SCE-1222556", "R-SCE-917977", "R-MMU-77387", "R-DDI-9639288", "R-SCE-77387", "R-DME-917977", "R-DME-6798695", "R-DME-77387", "R-CEL-77387", "R-HSA-983712", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-MMU-6798695", "R-DDI-917977", "R-MMU-983712", "R-DDI-983712", "R-HSA-917977", "R-DME-9639288"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-MMU-77387:r:Insulin receptor recycling", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-SCE-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-77387:r:Insulin receptor recycling", "R-CEL-77387:r:Insulin receptor recycling", "R-HSA-983712:r:Ion channel transport", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR002701": {"description": "Chorismate mutase II, prokaryotic-type", "go_ids": ["GO:0046417", "GO:0004106"], "go_terms": ["GO:0046417:chorismate metabolic process:P", "GO:0004106:chorismate mutase activity:F"], "name": "CM_II_prokaryot", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis"], "type": "Domain"}, "IPR002702": {"description": "Translation repressor RegA", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Transl_repress_RegA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002703": {"description": "Levivirus coat protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Levivir_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002704": {"description": "Peptidase C7 domain", "go_ids": ["GO:0004197", "GO:0006508"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_C7_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002705": {"description": "Peptidase C30/C16, Betacoronavirus", "go_ids": ["GO:0003968", "GO:0006508", "GO:0008234"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0006508:proteolysis:P", "GO:0008234:cysteine-type peptidase activity:F"], "name": "Pept_C30/C16_B_coronavir", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Domain"}, "IPR002706": {"description": "DNA-repair protein Xrcc1, N-terminal", "go_ids": ["GO:0000012", "GO:0003684", "GO:0005634"], "go_terms": ["GO:0000012:single strand break repair:P", "GO:0003684:damaged DNA binding:F", "GO:0005634:nucleus:C"], "name": "Xrcc1_N", "pathway_ids": ["R-RNO-5649702", "R-HSA-110381", "R-MMU-5649702", "R-RNO-110381", "R-HSA-5696397", "R-HSA-6782210", "R-MMU-5685939", "R-RNO-5685939", "R-MMU-6782210", "R-MMU-110381", "R-HSA-5685939", "R-HSA-5649702", "R-RNO-6782210"], "pathways": ["R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER"], "type": "Domain"}, "IPR002708": {"description": "Homocysteine biosynthesis enzyme, sulfur-incorporation", "go_ids": [], "go_terms": [], "name": "HcyBio", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002710": {"description": "Dilute domain", "go_ids": [], "go_terms": [], "name": "Dilute_dom", "pathway_ids": ["R-SPO-9013419", "R-SPO-9013425", "R-RNO-9824585", "R-HSA-264876", "R-RNO-418990", "R-HSA-2029482", "R-GGA-9824585", "R-MMU-2029482", "R-DDI-9013422", "R-MMU-432040", "R-MMU-418990", "R-RNO-2029482", "R-HSA-418990", "R-HSA-9824585", "R-HSA-432040", "R-MMU-9824585", "R-SPO-190873", "R-HSA-1445148", "R-SCE-9013425", "R-SCE-9013419", "R-SCE-9013420", "R-SPO-9013420", "R-RNO-432040", "R-HSA-9664422", "R-SCE-190873", "R-DDI-9013418"], "pathways": ["R-SPO-9013419:r:RHOT2 GTPase cycle", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-264876:r:Insulin processing", "R-RNO-418990:r:Adherens junctions interactions", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-418990:r:Adherens junctions interactions", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-418990:r:Adherens junctions interactions", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-SPO-190873:r:Gap junction degradation", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-SCE-9013420:r:RHOU GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SCE-190873:r:Gap junction degradation", "R-DDI-9013418:r:RHOBTB2 GTPase cycle"], "type": "Domain"}, "IPR002711": {"description": "HNH endonuclease", "go_ids": ["GO:0003676", "GO:0004519", "GO:0008270"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0004519:endonuclease activity:F", "GO:0008270:zinc ion binding:F"], "name": "HNH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002712": {"description": "Toxin CcdB", "go_ids": ["GO:0006276", "GO:0008657"], "go_terms": ["GO:0006276:plasmid maintenance:P", "GO:0008657:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity:F"], "name": "CcdB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002713": {"description": "FF domain", "go_ids": [], "go_terms": [], "name": "FF_domain", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9013405", "R-CFA-9013409", "R-MMU-9013106", "R-RNO-9013409", "R-MMU-9770562", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9013409", "R-MMU-9013404", "R-RNO-416550", "R-HSA-8849471", "R-DME-9035034", "R-DME-9013148", "R-CFA-9013408", "R-CEL-9770562", "R-RNO-9013408", "R-RNO-9013406", "R-RNO-9013404", "R-HSA-9013408", "R-MMU-8849471", "R-MMU-9035034", "R-DME-9013149", "R-CFA-9013406", "R-CFA-9013148", "R-CFA-8980692", "R-DME-8980692", "R-MMU-72163", "R-RNO-9013148", "R-RNO-9696273", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-SPO-9770562", "R-HSA-72163", "R-HSA-9013149", "R-HSA-8980692", "R-CFA-9013106", "R-MMU-9013406", "R-RNO-9696264", "R-HSA-9013026", "R-MMU-9696264", "R-MMU-416550", "R-HSA-416550", "R-RNO-9696270", "R-MMU-8980692", "R-RNO-8980692", "R-CFA-9013404", "R-MMU-9013148", "R-HSA-9013106", "R-CFA-9013149", "R-HSA-9013423", "R-CFA-8849471", "R-CFA-9696264", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013409", "R-DME-9013406", "R-RNO-9013106", "R-CFA-9696270", "R-DME-350407", "R-RNO-8849471", "R-HSA-9770562", "R-HSA-9696270", "R-CFA-416550", "R-CFA-9696273", "R-RNO-9013423", "R-MMU-9013026", "R-DME-8849471", "R-MMU-9696270", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9013149", "R-DME-9013423", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-CFA-9013409:r:RHOJ GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-9035034:r:RHOF GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-CFA-9013408:r:RHOG GTPase cycle", "R-CEL-9770562:r:mRNA Polyadenylation", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-CFA-8980692:r:RHOA GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-9696264:r:RND3 GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-CFA-9696270:r:RND2 GTPase cycle", "R-DME-350407:r:RHO1 GTPase cycle", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9696273:r:RND1 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR002715": {"description": "Nascent polypeptide-associated complex NAC domain", "go_ids": [], "go_terms": [], "name": "Nas_poly-pep-assoc_cplx_dom", "pathway_ids": ["R-HSA-9918487"], "pathways": ["R-HSA-9918487:r:Dengue Virus Genome Translation and Replication"], "type": "Domain"}, "IPR002716": {"description": "PIN domain", "go_ids": [], "go_terms": [], "name": "PIN_dom", "pathway_ids": ["R-MMU-9930044", "R-MMU-450385", "R-MMU-6791226", "R-HSA-9930044", "R-BTA-6791226", "R-CEL-450385", "R-SCE-450513", "R-MMU-975957", "R-DDI-6791226", "R-MMU-429958", "R-DRE-975957", "R-SPO-9930044", "R-CEL-450513", "R-HSA-6790901", "R-SCE-450385", "R-RNO-6791226", "R-HSA-450385", "R-SCE-429958", "R-HSA-975957", "R-SCE-975957", "R-MMU-450513", "R-SCE-6791226", "R-HSA-380994", "R-CEL-429958", "R-MMU-450604", "R-HSA-6791226", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-HSA-429958", "R-SPO-429958", "R-SPO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9930044:r:Nuclear RNA decay", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-450604:r:KSRP 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"R-DDI-69202:r:Cyclin E associated events during G1/S transition", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-1538133:r:G0 and Early G1", "R-HSA-69205:r:G1/S-Specific Transcription", "R-CEL-69202:r:Cyclin E associated events during G1/S transition", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Domain"}, "IPR002723": {"description": "N(4)-bis(aminopropyl)spermidine synthase, C-terminal", "go_ids": [], "go_terms": [], "name": "BpsA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002724": {"description": "Pyruvoyl-dependent arginine decarboxylase", "go_ids": ["GO:0006527", "GO:0008792"], "go_terms": ["GO:0006527:L-arginine catabolic process:P", "GO:0008792:arginine decarboxylase activity:F"], "name": "Pyruvoyl-dep_arg_deCO2ase", "pathway_ids": ["PWY-40", "PWY-43", "PWY-6834"], "pathways": ["PWY-40:t:putrescine biosynthesis I", "PWY-43:t:putrescine biosynthesis II", "PWY-6834:t:spermidine biosynthesis III"], "type": "Family"}, "IPR002725": {"description": "YgjP-like, metallopeptidase domain", "go_ids": [], "go_terms": [], "name": "YgjP-like_metallopeptidase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002726": {"description": "CDP-archaeol synthase, archaea", "go_ids": [], "go_terms": [], "name": "CarS_archaea", "pathway_ids": ["PWY-8365", "PWY-6349"], "pathways": ["PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-6349:t:C20,20 CDP-archaeol biosynthesis"], "type": "Family"}, "IPR002727": {"description": "Protein of unknown function DUF47", "go_ids": [], "go_terms": [], "name": "DUF47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002729": {"description": "CRISPR-associated protein Cas1", "go_ids": ["GO:0004519", "GO:0051607", "GO:0003676", "GO:0043571", "GO:0046872"], "go_terms": ["GO:0004519:endonuclease activity:F", "GO:0051607:defense response to virus:P", "GO:0003676:nucleic acid binding:F", "GO:0043571:maintenance of CRISPR repeat elements:P", "GO:0046872:metal ion binding:F"], "name": "CRISPR-assoc_Cas1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002730": {"description": "Ribonuclease P protein subunit Rpp29/RNP1", "go_ids": ["GO:0006396", "GO:0003723", "GO:0030677", "GO:0001682"], "go_terms": ["GO:0006396:RNA processing:P", "GO:0003723:RNA binding:F", "GO:0030677:ribonuclease P complex:C", "GO:0001682:tRNA 5'-leader removal:P"], "name": "Rpp29/RNP1", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR002731": {"description": "ATPase, BadF/BadG/BcrA/BcrD type", "go_ids": [], "go_terms": [], "name": "ATPase_BadF", "pathway_ids": ["R-MMU-446210", "R-RNO-446210", "R-HSA-446210"], "pathways": ["R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-RNO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine"], "type": "Domain"}, "IPR002732": {"description": "Holliday junction resolvase Hjc", "go_ids": [], "go_terms": [], "name": "Hjc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002733": {"description": "AMMECR1 domain", "go_ids": [], "go_terms": [], "name": "AMMECR1_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002734": {"description": "Bacterial bifunctional deaminase-reductase, C-terminal", "go_ids": ["GO:0008703", "GO:0009231"], "go_terms": ["GO:0008703:5-amino-6-(5-phosphoribosylamino)uracil reductase activity:F", "GO:0009231:riboflavin biosynthetic process:P"], "name": "RibDG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002735": {"description": "Translation initiation factor IF2/IF5 domain", "go_ids": ["GO:0003743", "GO:0006413"], "go_terms": ["GO:0003743:translation initiation factor activity:F", "GO:0006413:translational initiation:P"], "name": "Transl_init_fac_IF2/IF5_dom", "pathway_ids": ["R-HSA-72731", "R-SCE-382556", "R-SPO-382556", "R-SPO-72702", "R-DDI-382556", "R-DME-156827", "R-HSA-9833482", "R-DME-382556", "R-HSA-381042", "R-CEL-72702", "R-DME-72649", "R-SPO-72731", "R-HSA-156827", "R-CEL-72695", "R-CEL-381042", "R-DME-381042", "R-HSA-72695", "R-MMU-381042", "R-MMU-72649", "R-MMU-72706", "R-SCE-72731", "R-MMU-72731", "R-CEL-382556", "R-SCE-72695", "R-SCE-72702", "R-MMU-72695", "R-HSA-9840373", "R-MMU-382556", "R-SCE-156827", "R-DME-72695", "R-MMU-72702", "R-DME-72731", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-HSA-382556", "R-SPO-9840373", "R-HSA-72706", "R-RNO-72702", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-DME-9840373", "R-CEL-156827", "R-SCE-9840373", "R-HSA-9648895", "R-DDI-9840373", "R-SCE-72649", "R-CEL-72731", "R-DDI-72731", "R-CEL-72649", "R-CEL-9840373", "R-SPO-156827", "R-DDI-381042", "R-DME-72702", "R-DDI-156827", "R-DDI-72702", "R-MMU-9840373", "R-HSA-9633012"], "pathways": ["R-HSA-72731:r:Recycling of eIF2:GDP", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9833482:r:PKR-mediated signaling", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-381042:r:PERK regulates gene expression", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-381042:r:PERK regulates gene expression", "R-DME-381042:r:PERK regulates gene expression", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-381042:r:PERK regulates gene expression", "R-MMU-72649:r:Translation initiation complex formation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72731:r:Recycling of eIF2:GDP", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-9840373:r:Cellular response to mitochondrial stress", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-DDI-9840373:r:Cellular response to mitochondrial stress", "R-SCE-72649:r:Translation initiation complex formation", "R-CEL-72731:r:Recycling of eIF2:GDP", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-CEL-72649:r:Translation initiation complex formation", "R-CEL-9840373:r:Cellular response to mitochondrial stress", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-381042:r:PERK regulates gene expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR002736": {"description": "Triphosphoribosyl-dephospho-CoA protein", "go_ids": ["GO:0016310", "GO:0046917", "GO:0005524"], "go_terms": ["GO:0016310:phosphorylation:P", "GO:0046917:triphosphoribosyl-dephospho-CoA synthase activity:F", "GO:0005524:ATP binding:F"], "name": "CitG", "pathway_ids": ["PWY-5796"], "pathways": ["PWY-5796:t:malonate decarboxylase activation"], "type": "Family"}, "IPR002737": {"description": "MEMO1 family", "go_ids": [], "go_terms": [], "name": "MEMO1_fam", "pathway_ids": ["R-HSA-6785631", "R-MMU-6785631", "R-CEL-6785631", "R-RNO-6785631", "R-DRE-6785631"], "pathways": ["R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-DRE-6785631:r:ERBB2 Regulates Cell Motility"], "type": "Family"}, "IPR002738": {"description": "RNase P subunit p30", "go_ids": ["GO:0008033"], "go_terms": ["GO:0008033:tRNA processing:P"], "name": "RNase_P_p30", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-HSA-6784531"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR002739": {"description": "RNA-binding protein PAB1135-like", "go_ids": [], "go_terms": [], "name": "PAB1135-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002740": {"description": "EVE domain", "go_ids": [], "go_terms": [], "name": "EVE_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002742": {"description": "Desulfoferrodoxin, ferrous iron-binding domain", "go_ids": ["GO:0005506", "GO:0016491"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "Desulfoferrodoxin_Fe-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002744": {"description": "MIP18 family-like", "go_ids": [], "go_terms": [], "name": "MIP18-like", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Domain"}, "IPR002745": {"description": "Phosphotransferase KptA/Tpt1", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "Ptrans_KptA/Tpt1", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR002746": {"description": "Uncharacterised protein family UPF0216", "go_ids": [], "go_terms": [], "name": "UPF0216", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002747": {"description": "S-adenosyl-l-methionine hydroxide adenosyltransferase", "go_ids": [], "go_terms": [], "name": "SAM_OH_AdoTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002748": {"description": "Cobalt-precorrin-5B C(1)-methyltransferase CbiD", "go_ids": ["GO:0009236", "GO:0008168"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P", "GO:0008168:methyltransferase activity:F"], "name": "CbiD", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Family"}, "IPR002749": {"description": "AliA/AliB-like", "go_ids": [], "go_terms": [], "name": "AliA/AliB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002750": {"description": "CobE/GbiG C-terminal domain", "go_ids": ["GO:0009236"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P"], "name": "CobE/GbiG_C", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Domain"}, "IPR002751": {"description": "Metal transport protein CbiM/NikMN", "go_ids": ["GO:0016020", "GO:0000041"], "go_terms": ["GO:0016020:membrane:C", "GO:0000041:transition metal ion transport:P"], "name": "CbiM/NikMN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002753": {"description": "Uncharacterised protein family UPF0058", "go_ids": [], "go_terms": [], "name": "UPF0058", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002755": {"description": "DNA primase, small subunit", "go_ids": ["GO:0006269", "GO:0003899"], "go_terms": ["GO:0006269:DNA replication, synthesis of primer:P", "GO:0003899:DNA-directed RNA polymerase activity:F"], "name": "DNA_primase_S", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-MMU-174430", "R-CEL-69091", "R-CEL-68962", "R-PFA-69183", "R-SCE-69091", "R-CEL-113501", "R-CEL-69166", "R-DME-113501", "R-DME-68962", "R-CEL-69183", "R-SPO-69091", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-PFA-69166", "R-SCE-68952", "R-SPO-69166", "R-HSA-113501", "R-PFA-68952", "R-SCE-69183", "R-HSA-68952", "R-MMU-68962", "R-PFA-113501", "R-HSA-174430", "R-SPO-69183", "R-MMU-113501", "R-DME-69091", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-SCE-113501", "R-SCE-68962", "R-PFA-69091", "R-HSA-9710421", "R-MMU-68952", "R-SPO-113501", "R-SPO-68952", "R-CEL-68952", "R-SCE-69166", "R-MMU-69166", "R-HSA-69183", "R-SPO-68962", "R-HSA-69091", "R-PFA-68962", "R-MMU-174411", "R-MMU-69091", "R-DME-69166"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-CEL-69091:r:Polymerase switching", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-PFA-69183:r:Processive synthesis on the lagging strand", "R-SCE-69091:r:Polymerase switching", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-68962:r:Activation of the pre-replicative complex", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-SPO-69091:r:Polymerase switching", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-PFA-69166:r:Removal of the Flap Intermediate", "R-SCE-68952:r:DNA replication initiation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-PFA-68952:r:DNA replication initiation", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-HSA-68952:r:DNA replication initiation", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-PFA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-69091:r:Polymerase switching", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-PFA-69091:r:Polymerase switching", "R-HSA-9710421:r:Defective pyroptosis", "R-MMU-68952:r:DNA replication initiation", "R-SPO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-68952:r:DNA replication initiation", "R-CEL-68952:r:DNA replication initiation", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-69091:r:Polymerase switching", "R-PFA-68962:r:Activation of the pre-replicative complex", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Family"}, "IPR002756": {"description": "4-[[4-(2-aminoethyl)phenoxy]-methyl]-2-furanmethanamine-glutamate synthase", "go_ids": [], "go_terms": [], "name": "MfnF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002758": {"description": "Na+/H+ antiporter subunit E", "go_ids": ["GO:0006812", "GO:0008324", "GO:0016020"], "go_terms": ["GO:0006812:monoatomic cation transport:P", "GO:0008324:monoatomic cation transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "Cation_antiport_E", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002759": {"description": "RNase P subunit Pop5/Rpp14/Rnp2-like", "go_ids": ["GO:0030677", "GO:0001682"], "go_terms": ["GO:0030677:ribonuclease P complex:C", "GO:0001682:tRNA 5'-leader removal:P"], "name": "Pop5/Rpp14/Rnp2-like", "pathway_ids": ["R-HSA-6791226", "R-MMU-6791226", "R-HSA-6784531"], "pathways": ["R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR002760": {"description": "Putative O-antigen polymerase", "go_ids": [], "go_terms": [], "name": "O_anti_polymase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002762": {"description": "Sirohydrochlorin cobaltochelatase CbiX-like", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "CbiX-like", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Family"}, "IPR002763": {"description": "Protein of unknown function DUF72", "go_ids": [], "go_terms": [], "name": "DUF72", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002764": {"description": "CRISPR-associated protein Cas7/Cst2/DevR, subtype I-a/Apern", "go_ids": [], "go_terms": [], "name": "Cas7/Cst2/DevR_sub_I-a/Apern", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002765": {"description": "Uncharacterised protein family UPF0145, YbjQ-like", "go_ids": [], "go_terms": [], "name": "UPF0145_YbjQ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002767": {"description": "Thiamine-binding protein", "go_ids": [], "go_terms": [], "name": "Thiamine_BP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002769": {"description": "Translation initiation factor IF6", "go_ids": ["GO:0042256", "GO:0043022"], "go_terms": ["GO:0042256:cytosolic ribosome assembly:P", "GO:0043022:ribosome binding:F"], "name": "eIF6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002770": {"description": "Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, C-terminal", "go_ids": ["GO:0006730", "GO:0016740"], "go_terms": ["GO:0006730:one-carbon metabolic process:P", "GO:0016740:transferase activity:F"], "name": "ForMFR_H4MPT_ForTrfase_C", "pathway_ids": ["PWY-5209", "PWY-7784", "PWY-8305"], "pathways": ["PWY-5209:t:methyl-coenzyme M oxidation to CO2 I", "PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)", "PWY-8305:t:methoxylated aromatic compound degradation II"], "type": "Domain"}, "IPR002771": {"description": "Multiple antibiotic resistance (MarC)-related", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Multi_antbiot-R_MarC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002772": {"description": "Glycoside hydrolase family 3 C-terminal domain", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_3_C", "pathway_ids": ["PWY-3121", "PWY-6788", "PWY-7091", "PWY-7913", "PWY-7092", "PWY-5176", "PWY-6002"], "pathways": ["PWY-3121:t:linamarin degradation", "PWY-6788:t:cellulose degradation II (fungi)", "PWY-7091:t:linustatin bioactivation", "PWY-7913:t:firefly bioluminescence", "PWY-7092:t:neolinustatin bioactivation", "PWY-5176:t:coumarin biosynthesis (via 2-coumarate)", "PWY-6002:t:lotaustralin degradation"], "type": "Domain"}, "IPR002773": {"description": "Deoxyhypusine synthase", "go_ids": ["GO:0008612"], "go_terms": ["GO:0008612:peptidyl-hypusine biosynthetic process:P"], "name": "Deoxyhypusine_synthase", "pathway_ids": ["R-RNO-204626", "R-MMU-204626", "R-HSA-204626", "R-CEL-204626", "R-DDI-204626", "R-DME-204626", "R-SCE-204626", "R-SPO-204626", "R-BTA-204626"], "pathways": ["R-RNO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DDI-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DME-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SCE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-BTA-204626:r:Hypusine synthesis from eIF5A-lysine"], "type": "Family"}, "IPR002774": {"description": "Flagellin, archaeal-type", "go_ids": ["GO:0005198", "GO:0097588"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0097588:archaeal or bacterial-type flagellum-dependent cell motility:P"], "name": "Flagellin_arc-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002775": {"description": "DNA/RNA-binding protein Alba-like", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "DNA/RNA-bd_Alba-like", "pathway_ids": ["R-MMU-6791226", "R-HSA-6784531", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR002777": {"description": "Prefoldin beta-like", "go_ids": ["GO:0006457", "GO:0016272"], "go_terms": ["GO:0006457:protein folding:P", "GO:0016272:prefoldin complex:C"], "name": "PFD_beta-like", "pathway_ids": ["R-HSA-389957"], "pathways": ["R-HSA-389957:r:Prefoldin mediated transfer of substrate to CCT/TriC"], "type": "Family"}, "IPR002778": {"description": "Signal recognition particle, SRP19 subunit", "go_ids": ["GO:0006614", "GO:0008312", "GO:0048500"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P", "GO:0008312:7S RNA binding:F", "GO:0048500:signal recognition particle:C"], "name": "Signal_recog_particle_SRP19", "pathway_ids": ["R-HSA-1799339", "R-DME-1799339", "R-SPO-1799339", "R-CEL-1799339", "R-SCE-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-BTA-1799339", "R-MMU-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR002780": {"description": "Hydrogenase formation HypD protein", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Hyd_form_HypD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002781": {"description": "Transmembrane protein TauE-like, transmembrane domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TM_pro_TauE-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002782": {"description": "Mut7-C RNAse domain", "go_ids": [], "go_terms": [], "name": "Mut7-C_RNAse_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002784": {"description": "Large ribosomal subunit protein eL14 domain", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL14_dom", "pathway_ids": ["R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-SPO-9954714", "R-HSA-9010553", "R-MMU-72689", "R-RNO-72706", "R-SPO-975957", "R-SCE-9954709", "R-HSA-156827", "R-RNO-72689", "R-RNO-1799339", "R-MMU-9954709", "R-DME-9954716", "R-DME-72706", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-SCE-975957", "R-RNO-9954716", "R-DDI-9954714", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SPO-9954709", "R-HSA-1799339", "R-SPO-975956", "R-SCE-156827", "R-HSA-2408557", "R-DME-975956", 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"R-HSA-192823:r:Viral mRNA Translation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-2408557:r:Selenocysteine synthesis", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR002786": {"description": "Inosine/xanthosine triphosphatase", "go_ids": [], "go_terms": [], "name": "Non_canon_purine_NTPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002789": {"description": "Helicase HerA, central domain", "go_ids": [], "go_terms": [], "name": "HerA_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002790": {"description": "Conserved hypothetical protein CHP00288", "go_ids": [], "go_terms": [], "name": "CHP00288", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002791": {"description": "Damage-control phosphatase ARMT1-like, metal-binding domain", "go_ids": [], "go_terms": [], "name": "ARMT1-like_metal-bd", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664", "R-MMU-199220", "R-RNO-199220", "R-HSA-199220"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Domain"}, "IPR002792": {"description": "TRAM domain", "go_ids": [], "go_terms": [], "name": "TRAM_dom", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR002793": {"description": "Endonuclease NucS", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "Endonuclease_NucS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002794": {"description": "Protein of unknown function DUF92, TMEM19", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "DUF92_TMEM19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002797": {"description": "Polysaccharide biosynthesis protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Polysacc_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002798": {"description": "Stage II sporulation protein M-like", "go_ids": [], "go_terms": [], "name": "SpoIIM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002800": {"description": "Chorismate pyruvate-lyase Rv2949c-like", "go_ids": [], "go_terms": [], "name": "Rv2949c-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002801": {"description": "Aspartate transcarbamylase regulatory subunit", "go_ids": ["GO:0006207", "GO:0009347"], "go_terms": ["GO:0006207:'de novo' pyrimidine nucleobase biosynthetic process:P", "GO:0009347:aspartate carbamoyltransferase complex:C"], "name": "Asp_carbamoylTrfase_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002802": {"description": "Endonuclease dU", "go_ids": [], "go_terms": [], "name": "Endo_dU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002803": {"description": "Fructose-1,6-bisphosphatase, class V", "go_ids": [], "go_terms": [], "name": "FBPase_V", "pathway_ids": ["PWY-1042", "PWY-8178", "PWY-8404", "PWY-6142", "PWY-1861", "PWY-7385", "PWY-5484"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)"], "type": "Family"}, "IPR002804": {"description": "Archease", "go_ids": [], "go_terms": [], "name": "Archease", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR002805": {"description": "Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, archaeal type", "go_ids": [], "go_terms": [], "name": "Nict_dMeBzImd_PRibTrfase_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002808": {"description": "Adenosylcobinamide amidohydrolase, CbiZ", "go_ids": [], "go_terms": [], "name": "AdoCbi_amidolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002809": {"description": "Integral membrane protein EMC3/TMCO1-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "EMC3/TMCO1", "pathway_ids": ["R-BTA-8980692", "R-DRE-8980692", "R-HSA-8980692", "R-MMU-8980692", "R-RNO-8980692"], "pathways": ["R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle"], "type": "Family"}, "IPR002810": {"description": "NfeD-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NfeD-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002811": {"description": "Aspartate dehydrogenase", "go_ids": ["GO:0009435", "GO:0033735"], "go_terms": ["GO:0009435:NAD+ biosynthetic process:P", "GO:0033735:L-aspartate dehydrogenase [NAD(P)+] activity:F"], "name": "Asp_DH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002812": {"description": "3-dehydroquinate synthase", "go_ids": ["GO:0009073", "GO:0003856", "GO:0016491"], "go_terms": ["GO:0009073:aromatic amino acid biosynthetic process:P", "GO:0003856:3-dehydroquinate synthase activity:F", "GO:0016491:oxidoreductase activity:F"], "name": "DHQS", "pathway_ids": ["PWY-6160"], "pathways": ["PWY-6160:t:3-dehydroquinate biosynthesis II (archaea)"], "type": "Family"}, "IPR002813": {"description": "Arginine biosynthesis protein ArgJ", "go_ids": ["GO:0004358", "GO:0006526"], "go_terms": ["GO:0004358:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor:F", "GO:0006526:L-arginine biosynthetic process:P"], "name": "Arg_biosynth_ArgJ", "pathway_ids": ["PWY-5154"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Family"}, "IPR002815": {"description": "Spo11/DNA topoisomerase VI subunit A", "go_ids": ["GO:0003677", "GO:0005694", "GO:0003918"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005694:chromosome:C", "GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F"], "name": "Spo11/TopoVI_A", "pathway_ids": ["R-HSA-912446"], "pathways": ["R-HSA-912446:r:Meiotic recombination"], "type": "Family"}, "IPR002816": {"description": "TraB/PrgY/GumN, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TraB/PrgY/GumN_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002817": {"description": "Phosphomethylpyrimidine synthase ThiC/5-hydroxybenzimidazole synthase BzaA/B", "go_ids": ["GO:0009228", "GO:0051536"], "go_terms": ["GO:0009228:thiamine biosynthetic process:P", "GO:0051536:iron-sulfur cluster binding:F"], "name": "ThiC/BzaA/B", "pathway_ids": ["PWY-6890"], "pathways": ["PWY-6890:t:4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I"], "type": "Family"}, "IPR002818": {"description": "DJ-1/PfpI-like", "go_ids": [], "go_terms": [], "name": "DJ-1/PfpI-like", "pathway_ids": ["R-MMU-9646399", "R-HSA-9646399", "R-DRE-9646399", "R-MMU-3899300", "R-RNO-9646399", "R-HSA-9613829", "R-DME-9646399", "R-BTA-9646399", "R-BTA-3899300", "R-HSA-9615710", "R-HSA-3899300", "R-CEL-3899300", "R-SPO-3899300", "R-RNO-3899300", "R-CEL-9646399"], "pathways": ["R-MMU-9646399:r:Aggrephagy", "R-HSA-9646399:r:Aggrephagy", "R-DRE-9646399:r:Aggrephagy", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9646399:r:Aggrephagy", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-DME-9646399:r:Aggrephagy", "R-BTA-9646399:r:Aggrephagy", "R-BTA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9646399:r:Aggrephagy"], "type": "Domain"}, "IPR002820": {"description": "Molybdopterin cofactor biosynthesis C (MoaC) domain", "go_ids": ["GO:0006777"], "go_terms": ["GO:0006777:Mo-molybdopterin cofactor biosynthetic process:P"], "name": "Mopterin_CF_biosynth-C_dom", "pathway_ids": ["PWY-6823", "R-DME-947581", "R-BTA-947581", "R-DDI-947581", "R-HSA-947581", "R-MMU-947581"], "pathways": ["PWY-6823:t:molybdopterin biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR002821": {"description": "Hydantoinase A/oxoprolinase", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Hydantoinase_A", "pathway_ids": ["R-HSA-5578998", "R-RNO-174403", "R-HSA-174403", "R-DDI-174403", "R-MMU-174403", "R-SCE-174403", "R-SPO-174403"], "pathways": ["R-HSA-5578998:r:Defective OPLAH causes OPLAHD", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-DDI-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling"], "type": "Domain"}, "IPR002822": {"description": "Nickel insertion protein", "go_ids": [], "go_terms": [], "name": "Ni_insertion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002823": {"description": "Protein of unknown function DUF112, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF112_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002825": {"description": "Uncharacterized protein MJ0137-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "MJ0137-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002826": {"description": "6-hydroxymethylpterin diphosphokinase MptE-like", "go_ids": [], "go_terms": [], "name": "MptE-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002828": {"description": "Survival protein SurE-like phosphatase/nucleotidase", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "SurE-like_Pase/nucleotidase", "pathway_ids": ["PWY-7821", "PWY-7185", "PWY-5381", "PWY-6596", "PWY-5695", "PWY-6607", "PWY-6608", "PWY-6606"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-5381:t:NAD salvage (plants)", "PWY-6596:t:adenosine nucleotides degradation I", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II"], "type": "Domain"}, "IPR002829": {"description": "Protein of unknown function DUF116", "go_ids": [], "go_terms": [], "name": "DUF116", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002830": {"description": "UbiD decarboxylyase family", "go_ids": ["GO:0016831"], "go_terms": ["GO:0016831:carboxy-lyase activity:F"], "name": "UbiD", "pathway_ids": ["PWY-6978", "PWY-5856", "PWY-6708", "PWY-5857", "PWY-5855"], "pathways": ["PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)"], "type": "Family"}, "IPR002831": {"description": "Transcription regulator TrmB, N-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_TrmB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002833": {"description": "Peptidyl-tRNA hydrolase, PTH2", "go_ids": ["GO:0004045"], "go_terms": ["GO:0004045:peptidyl-tRNA hydrolase activity:F"], "name": "PTH2", "pathway_ids": ["R-MMU-5689880", "R-BTA-5689880", "R-DME-5689880", "R-HSA-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR002835": {"description": "Phosphoenolpyruvate guanylyltransferase CofC", "go_ids": ["GO:0043814"], "go_terms": ["GO:0043814:phospholactate guanylyltransferase activity:F"], "name": "CofC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002836": {"description": "PDCD5-like", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA 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["R-MMU-1222556", "R-CEL-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-RNO-1222556", "R-HSA-9639288", "R-RNO-983712", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-DDI-1222556", "R-SPO-1222556", "R-RNO-917977", "R-DDI-9639288", "R-SCE-917977", "R-SCE-1222556", "R-BTA-1222556", "R-MMU-77387", "R-SCE-77387", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-RNO-77387", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-RNO-9639288", "R-DDI-917977", "R-DDI-983712", "R-HSA-917977", "R-MMU-983712", "R-BTA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", 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"ATPase, V0 complex, C/D subunit", "go_ids": ["GO:0046961"], "go_terms": ["GO:0046961:proton-transporting ATPase activity, rotational mechanism:F"], "name": "ATPase_V0-cplx_csu/dsu", "pathway_ids": ["R-MMU-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-DRE-9639288", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-XTR-77387", "R-RNO-1222556", "R-GGA-917977", "R-HSA-9639288", "R-DRE-983712", "R-RNO-983712", "R-XTR-1222556", "R-HSA-1222556", "R-XTR-917977", "R-SPO-917977", "R-DRE-1222556", "R-SPO-1222556", "R-DDI-1222556", "R-GGA-9639288", "R-XTR-983712", "R-RNO-917977", "R-SCE-917977", "R-SCE-1222556", "R-MMU-77387", "R-DDI-9639288", "R-BTA-1222556", "R-SCE-77387", "R-HSA-381038", "R-DRE-917977", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-GGA-77387", "R-RNO-77387", "R-BTA-917977", "R-HSA-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-XTR-9639288", "R-RNO-9639288", "R-GGA-1222556", "R-DRE-77387", "R-DDI-917977", "R-MMU-983712", "R-DDI-983712", "R-HSA-917977", "R-BTA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-XTR-77387:r:Insulin receptor recycling", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-GGA-917977:r:Transferrin endocytosis and recycling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DRE-983712:r:Ion channel transport", "R-RNO-983712:r:Ion channel transport", "R-XTR-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-XTR-917977:r:Transferrin endocytosis and recycling", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-DRE-1222556:r:ROS and RNS production in phagocytes", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-GGA-9639288:r:Amino acids regulate mTORC1", "R-XTR-983712:r:Ion channel transport", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-MMU-77387:r:Insulin receptor recycling", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-SCE-77387:r:Insulin receptor recycling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DRE-917977:r:Transferrin endocytosis and recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-GGA-77387:r:Insulin receptor recycling", "R-RNO-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-GGA-1222556:r:ROS and RNS production in phagocytes", "R-DRE-77387:r:Insulin receptor recycling", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-BTA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR002844": {"description": "F420-dependent methylenetetrahydromethanopterin dehydrogenase", "go_ids": ["GO:0008901", "GO:0015948"], "go_terms": ["GO:0008901:ferredoxin hydrogenase activity:F", "GO:0015948:methanogenesis:P"], "name": "MTD", "pathway_ids": ["PWY-8113", "PWY-5209", "PWY-8305", "PWY-8112", "PWY-5198"], "pathways": ["PWY-8113:t:3PG-factor 420 biosynthesis", "PWY-5209:t:methyl-coenzyme M oxidation to CO2 I", "PWY-8305:t:methoxylated aromatic compound degradation II", "PWY-8112:t:factor 420 biosynthesis I (archaea)", "PWY-5198:t:factor 420 biosynthesis II (mycobacteria)"], "type": "Family"}, "IPR002845": {"description": "tRNA ribose 2'-O-methyltransferase, aTrm56", "go_ids": ["GO:0002128", "GO:0005737", "GO:0008175"], "go_terms": ["GO:0002128:tRNA nucleoside ribose methylation:P", "GO:0005737:cytoplasm:C", "GO:0008175:tRNA methyltransferase activity:F"], "name": "tRNA_mtfrase_aTrm56", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002846": {"description": "NrpR regulatory domain", "go_ids": [], "go_terms": [], "name": "NRD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002847": {"description": "Coenzyme F420:L-glutamate ligase-like domain", "go_ids": [], "go_terms": [], "name": "F420-0_gamma-glut_ligase-dom", "pathway_ids": ["PWY-5199"], "pathways": ["PWY-5199:t:factor 420 polyglutamylation"], "type": "Domain"}, "IPR002848": {"description": "Translin family", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "Translin_fam", "pathway_ids": ["R-MMU-426486", "R-HSA-426486", "R-RNO-426486", "R-BTA-426486", "R-SPO-426486"], "pathways": ["R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-BTA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-SPO-426486:r:Small interfering RNA (siRNA) biogenesis"], "type": "Family"}, "IPR002849": {"description": "Protein of unknown function DUF131", "go_ids": [], "go_terms": [], "name": "DUF131", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002850": {"description": "MJ1680-like", "go_ids": [], "go_terms": [], "name": "MJ1680-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002852": {"description": "Uncharacterised protein family UPF0251", "go_ids": [], "go_terms": [], "name": "UPF0251", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002853": {"description": "Transcription initiation factor IIE subunit alpha, N-terminal", "go_ids": ["GO:0006367"], "go_terms": ["GO:0006367:transcription initiation at RNA polymerase II promoter:P"], "name": "TFIIE_asu", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-BTA-73776", "R-MMU-75953", "R-SCE-75953", "R-BTA-76042", "R-DDI-73776", "R-SPO-6807505", "R-HSA-167162", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-MMU-73776", "R-DDI-76042", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-BTA-73779", "R-SPO-75953", "R-SCE-73779", "R-BTA-75953", "R-DDI-73779", "R-BTA-674695", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-HSA-167161", "R-SCE-674695", "R-SPO-73779", "R-HSA-674695", "R-HSA-76042", "R-DDI-75953", "R-BTA-6807505", "R-SPO-73776", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167161:r:HIV Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR002855": {"description": "Phosphopantoate/pantothenate synthetase", "go_ids": [], "go_terms": [], "name": "PPS/PS", "pathway_ids": ["PWY-6654"], "pathways": ["PWY-6654:t:phosphopantothenate biosynthesis III (archaea)"], "type": "Family"}, "IPR002857": {"description": "Zinc finger, CXXC-type", "go_ids": ["GO:0003677", "GO:0008270"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008270:zinc ion binding:F"], "name": "Znf_CXXC", "pathway_ids": ["R-HSA-4655427", "R-HSA-3769402", "R-HSA-9772755", "R-HSA-8936459", "R-HSA-8951664", "R-HSA-5368598", "R-HSA-427413", "R-MMU-201722", "R-MMU-212300", "R-MMU-8939236", "R-MMU-8951664", "R-BTA-9772755", "R-RNO-212300", "R-HSA-3214841", "R-MMU-3214842", "R-MMU-4655427", "R-HSA-5221030", "R-MMU-9772755", "R-HSA-9616222", "R-HSA-5334118", "R-HSA-9701898", "R-HSA-9018519", "R-MMU-8936459", "R-HSA-381038", "R-MMU-3214841", "R-DME-9772755", "R-MMU-3899300", "R-HSA-3214842", "R-HSA-9931521", "R-HSA-983168", "R-HSA-9710421", "R-RNO-4655427", "R-HSA-9931510", "R-HSA-9725371", "R-HSA-212300", "R-HSA-9931512", "R-HSA-9909649", "R-HSA-201722", "R-HSA-9821002", "R-MMU-983168", "R-HSA-3899300", "R-HSA-8939236"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8951664:r:Neddylation", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-8951664:r:Neddylation", "R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214842:r:HDMs demethylate histones", "R-MMU-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-5221030:r:TET1,2,3 and TDG demethylate DNA", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-5334118:r:DNA methylation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9710421:r:Defective pyroptosis", "R-RNO-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "type": "Domain"}, "IPR002859": {"description": "PKD/REJ-like domain", "go_ids": [], "go_terms": [], "name": "PKD/REJ-like", "pathway_ids": ["R-HSA-5620916", "R-MMU-5620916"], "pathways": ["R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium"], "type": "Domain"}, "IPR002860": {"description": "BNR repeat", "go_ids": [], "go_terms": [], "name": "BNR_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR002861": {"description": "Reeler domain", "go_ids": [], "go_terms": [], "name": "Reeler_dom", "pathway_ids": ["R-BTA-5173214", "R-RNO-5173214", "R-HSA-8866376", "R-HSA-5173214", "R-MMU-8866376", "R-HSA-5083635", "R-MMU-5173214", "R-RNO-8866376"], "pathways": ["R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-8866376:r:Reelin signalling pathway", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-8866376:r:Reelin signalling pathway", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-8866376:r:Reelin signalling pathway"], "type": "Domain"}, "IPR002862": {"description": "Domain of unknown function DUF16", "go_ids": [], "go_terms": [], "name": "DUF16", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002864": {"description": "Acyl-ACP thioesterase, N-terminal hotdog domain", "go_ids": ["GO:0006633", "GO:0016790"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P", "GO:0016790:thiolester hydrolase activity:F"], "name": "Acyl-ACP_thioesterase_NHD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002866": {"description": "Maturase MatK", "go_ids": ["GO:0006397", "GO:0009507"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:0009507:chloroplast:C"], "name": "Maturase_MatK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002867": {"description": "IBR domain", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "IBR_dom", "pathway_ids": ["R-BTA-9909505", "R-DME-983168", "R-HSA-9646399", "R-MMU-9909505", "R-HSA-9833482", "R-HSA-8951664", "R-HSA-977225", "R-HSA-936440", "R-DRE-174113", "R-MMU-5205685", "R-MMU-5357956", "R-CEL-983168", "R-HSA-1169408", "R-HSA-9909505", "R-DRE-8866654", "R-DRE-983168", "R-MMU-9833482", "R-CEL-9909505", "R-HSA-5357905", "R-MMU-5689877", "R-RNO-5689877", "R-SPO-983168", "R-SCE-9646399", "R-HSA-9833110", "R-HSA-5205685", "R-SCE-983168", "R-DRE-176408", "R-HSA-5689877", "R-SCE-5205685", "R-DDI-1169408", "R-MMU-8866654", "R-DDI-9833482", "R-MMU-5357786", "R-RNO-5205685", "R-SSC-983168", "R-HSA-5675482", "R-DME-5689877", "R-MMU-5675482", "R-CEL-9833482", "R-DME-9646399", "R-HSA-983168", "R-MMU-1169408", "R-HSA-5357786", "R-HSA-8866654", "R-DDI-983168", "R-MMU-9646399", "R-CEL-1169408", "R-DDI-9909505", "R-DME-5205685", "R-HSA-5357956", "R-DRE-176417", "R-MMU-5357905", "R-MMU-983168", "R-RNO-9646399", "R-RNO-5675482", "R-BTA-1169408", "R-RNO-983168", "R-BTA-9833482", "R-DRE-68881"], "pathways": ["R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-983168:r:Antigen 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signaling", "R-MMU-5689877:r:Josephin domain DUBs", "R-RNO-5689877:r:Josephin domain DUBs", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9646399:r:Aggrephagy", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5689877:r:Josephin domain DUBs", "R-SCE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-DME-5689877:r:Josephin domain DUBs", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-CEL-9833482:r:PKR-mediated signaling", "R-DME-9646399:r:Aggrephagy", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9646399:r:Aggrephagy", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-DRE-176417:r:Phosphorylation of Emi1", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-9833482:r:PKR-mediated signaling", "R-DRE-68881:r:Mitotic Metaphase/Anaphase Transition"], "type": "Domain"}, "IPR002868": {"description": "Hepatitis C virus, Non-structural 5a protein", "go_ids": ["GO:0003968", "GO:0004197", "GO:0004252", "GO:0017111"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0004197:cysteine-type endopeptidase activity:F", "GO:0004252:serine-type endopeptidase activity:F", "GO:0017111:ribonucleoside triphosphate phosphatase activity:F"], "name": "HCV_NS5a", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR002869": {"description": "Pyruvate-flavodoxin oxidoreductase, central domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Pyrv_flavodox_OxRed_cen", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR002870": {"description": "Peptidase M12B, propeptide", "go_ids": [], "go_terms": [], "name": "Peptidase_M12B_N", "pathway_ids": ["PWY-8119", "R-HSA-1474228", "R-HSA-6798695", "R-MMU-2534343", "R-HSA-5083635", "R-RNO-1474228", "R-BTA-5173214", "R-MMU-9762292", "R-HSA-1650814", "R-RNO-8941237", "R-RNO-5173214", "R-HSA-5173214", "R-MMU-8941237", "R-HSA-2534343", "R-MMU-1650814", "R-HSA-8941237", "R-MMU-5173214", "R-MMU-5682910", "R-HSA-177929", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-5682910", "R-HSA-1442490", "R-BTA-1650814", "R-MMU-1474228"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-8941237:r:Invadopodia formation", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-8941237:r:Invadopodia formation", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-8941237:r:Invadopodia formation", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR002871": {"description": "NIF system FeS cluster assembly, NifU, N-terminal", "go_ids": ["GO:0005506", "GO:0016226", "GO:0051536"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016226:iron-sulfur cluster assembly:P", "GO:0051536:iron-sulfur cluster binding:F"], "name": "NIF_FeS_clus_asmbl_NifU_N", "pathway_ids": ["R-SPO-9865881", "R-HSA-1362409", "R-HSA-9865881", "R-HSA-9854311", "R-PFA-1362409", "R-SCE-1362409", "R-MMU-9854311", "R-MMU-1362409", "R-DME-9865881", "R-DME-1362409", "R-SCE-9865881", "R-HSA-9694301", "R-SPO-1362409", "R-MMU-9865881"], "pathways": ["R-SPO-9865881:r:Complex III assembly", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9865881:r:Complex III assembly", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-PFA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DME-9865881:r:Complex III assembly", "R-DME-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SCE-9865881:r:Complex III assembly", "R-HSA-9694301:r:Maturation of replicase proteins", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR002872": {"description": "Proline dehydrogenase domain", "go_ids": [], "go_terms": [], "name": "Proline_DH_dom", "pathway_ids": ["PWY-6922", "PWY-5737", "R-DME-389661", "R-SPO-70688", "R-CEL-70688", "R-HSA-70688", "R-SPO-389661", "R-SCE-70688", "R-DDI-70688", "R-DME-70688", "R-MMU-70688", "R-MMU-389661", "R-DDI-389661", "R-CEL-389661", "R-RNO-389661", "R-HSA-389661", "R-RNO-70688", "R-SCE-389661"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-5737:t:(5R)-carbapenem carboxylate biosynthesis", "R-DME-389661:r:Glyoxylate metabolism and glycine degradation", "R-SPO-70688:r:Proline catabolism", "R-CEL-70688:r:Proline catabolism", "R-HSA-70688:r:Proline catabolism", "R-SPO-389661:r:Glyoxylate metabolism and glycine degradation", "R-SCE-70688:r:Proline catabolism", "R-DDI-70688:r:Proline catabolism", "R-DME-70688:r:Proline catabolism", "R-MMU-70688:r:Proline catabolism", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-DDI-389661:r:Glyoxylate metabolism and glycine degradation", "R-CEL-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-70688:r:Proline catabolism", "R-SCE-389661:r:Glyoxylate metabolism and glycine degradation"], "type": "Domain"}, "IPR002873": {"description": "Rotavirus non-structural protein NSP3", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Rotavirus_NSP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002874": {"description": "Alphaherpesvirus glycoprotein I", "go_ids": ["GO:0043657"], "go_terms": ["GO:0043657:host cell:C"], "name": "Herpes_gI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002876": {"description": "Transcriptional regulator TACO1-like", "go_ids": [], "go_terms": [], "name": "Transcrip_reg_TACO1-like", "pathway_ids": ["R-HSA-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR002877": {"description": "Ribosomal RNA methyltransferase, FtsJ domain", "go_ids": ["GO:0008168", "GO:0032259"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0032259:methylation:P"], "name": "RNA_MeTrfase_FtsJ_dom", "pathway_ids": ["R-MMU-6791226", "R-HSA-6793080", "R-HSA-6782315", "R-HSA-9920588", "R-HSA-6791226", "R-HSA-9918476", "R-HSA-9918432", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR002878": {"description": "ChsH2, C-terminal OB-fold domain", "go_ids": [], "go_terms": [], "name": "ChsH2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002880": {"description": "Pyruvate flavodoxin/ferredoxin oxidoreductase, pyrimidine binding domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Pyrv_Fd/Flavodoxin_OxRdtase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002881": {"description": "Domain of unknown function DUF58", "go_ids": [], "go_terms": [], "name": "DUF58", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002882": {"description": "2-phospho-L-lactate transferase CofD", "go_ids": ["GO:0043743"], "go_terms": ["GO:0043743:LPPG:FO 2-phospho-L-lactate transferase activity:F"], "name": "CofD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002883": {"description": "CBM10/dockerin domain", "go_ids": [], "go_terms": [], "name": "CBM10/Dockerin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002884": {"description": "P domain", "go_ids": ["GO:0004252", "GO:0006508"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "P_dom", "pathway_ids": ["R-HSA-186797", "R-CEL-1592389", "R-DME-2173789", "R-HSA-159782", "R-HSA-171286", "R-HSA-8963889", "R-HSA-264876", "R-HSA-9918485", "R-CEL-1566948", "R-MMU-422085", "R-MMU-1912420", "R-HSA-9828806", "R-RNO-8963889", "R-RNO-422085", "R-HSA-5210891", "R-MMU-1566948", "R-HSA-209952", "R-RNO-9768727", "R-HSA-2173789", "R-MMU-1592389", "R-MMU-2173796", "R-CEL-2173796", "R-HSA-9694614", "R-DME-1592389", "R-RNO-1566948", "R-HSA-422085", "R-HSA-9820960", "R-HSA-9918476", "R-HSA-167060", "R-SCE-2173796", "R-HSA-9768727", "R-MMU-186797", "R-MMU-9768727", "R-RNO-2173796", "R-SPO-2173796", "R-HSA-6809371", "R-HSA-9662834", "R-HSA-977225", "R-RNO-159782", "R-HSA-1566948", "R-MMU-209952", "R-MMU-9953170", "R-HSA-1181150", "R-DME-8963889", "R-MMU-167060", "R-HSA-381771", "R-HSA-2173796", "R-RNO-2173789", "R-HSA-1442490", "R-HSA-400511", "R-HSA-1912420", "R-RNO-9953170", "R-MMU-2173789", "R-HSA-9733458", "R-RNO-1592389", "R-RNO-186797", "R-MMU-8963889", "R-HSA-9679191", "R-HSA-1592389", "R-RNO-1442490", "R-RNO-209952", "R-MMU-159782", "R-RNO-167060", "R-DME-2173796", "R-CEL-186797", "R-MMU-1442490", "R-HSA-9953170", "R-DME-186797"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-171286:r:Synthesis and processing of ENV and VPU", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-264876:r:Insulin processing", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-CEL-1566948:r:Elastic fibre formation", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-209952:r:Peptide hormone biosynthesis", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9694614:r:Attachment and Entry", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1566948:r:Elastic fibre formation", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-167060:r:NGF processing", "R-SCE-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SPO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-1566948:r:Elastic fibre formation", "R-MMU-209952:r:Peptide hormone biosynthesis", "R-MMU-9953170:r:GBP-mediated host defense", "R-HSA-1181150:r:Signaling by NODAL", "R-DME-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-167060:r:NGF processing", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-1442490:r:Collagen degradation", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-RNO-9953170:r:GBP-mediated host defense", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1442490:r:Collagen degradation", "R-RNO-209952:r:Peptide hormone biosynthesis", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-167060:r:NGF processing", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-186797:r:Signaling by PDGF", "R-MMU-1442490:r:Collagen degradation", "R-HSA-9953170:r:GBP-mediated host defense", "R-DME-186797:r:Signaling by PDGF"], "type": "Domain"}, "IPR002885": {"description": "Pentatricopeptide repeat", "go_ids": [], "go_terms": [], "name": "PPR_rpt", "pathway_ids": ["R-HSA-9937008", "R-MMU-163282", "R-HSA-5419276", "R-MMU-9937383", "R-MMU-9913635", "R-HSA-9937383", "R-HSA-8876198", "R-DRE-5389840", "R-BTA-9937383", "R-BTA-5389840", "R-HSA-9836573", "R-MMU-8876198", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-DME-9937383", "R-DRE-5419276"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-MMU-163282:r:Mitochondrial transcription initiation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Repeat"}, "IPR002888": {"description": "[2Fe-2S]-binding", "go_ids": ["GO:0016491", "GO:0046872"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0046872:metal ion binding:F"], "name": "2Fe-2S-bd", "pathway_ids": ["R-MMU-9748787", "R-RNO-8851680", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", "R-RNO-74259", "R-GGA-421178", "R-DME-964975", "R-MMU-8851680", "R-HSA-9748787", "R-HSA-74259", "R-RNO-964975", "R-DME-74259", "R-MMU-964975", "R-CEL-964975", "R-DME-9748787", "R-MMU-74259", "R-DDI-964975", "R-RNO-9748787", "R-DDI-74259"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-GGA-421178:r:Urate synthesis", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-74259:r:Purine catabolism", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Domain"}, "IPR002889": {"description": "Carbohydrate-binding WSC", "go_ids": [], "go_terms": [], "name": "WSC_carb-bd", "pathway_ids": ["R-HSA-3772470", "R-HSA-5620916", "R-HSA-201681", "R-MMU-5620916", "R-MMU-3772470", "R-DME-1971475", "R-CEL-1971475", "R-HSA-5339717", "R-RNO-3772470"], "pathways": ["R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-RNO-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "type": "Domain"}, "IPR002890": {"description": "Macroglobulin domain", "go_ids": ["GO:0004866"], "go_terms": ["GO:0004866:endopeptidase inhibitor activity:F"], "name": "MG2", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-MMU-163125", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-163125", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR002891": {"description": "APS kinase", "go_ids": ["GO:0000103", "GO:0005524", "GO:0004020"], "go_terms": ["GO:0000103:sulfate assimilation:P", "GO:0005524:ATP binding:F", "GO:0004020:adenylylsulfate kinase activity:F"], "name": "APS", "pathway_ids": ["PWY-5340", "R-MMU-174362", "R-MTU-936635", "R-HSA-6802952", "R-SCE-174362", "R-HSA-174362", "R-SPO-174362", "R-HSA-2408550", "R-CEL-174362", "R-HSA-3560796"], "pathways": ["PWY-5340:t:sulfate activation for sulfonation", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-MTU-936635:r:Sulfate assimilation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-SCE-174362:r:Transport and metabolism of PAPS", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-SPO-174362:r:Transport and metabolism of PAPS", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-HSA-3560796:r:Defective PAPSS2 causes SEMD-PA"], "type": "Family"}, "IPR002893": {"description": "Zinc finger, MYND-type", "go_ids": [], "go_terms": [], "name": "Znf_MYND", "pathway_ids": ["R-MMU-6804760", "R-DRE-6804760", "R-MMU-3214841", "R-HSA-5689880", "R-CEL-3214841", "R-HSA-6804760", "R-SPO-3214841", "R-BTA-6804760", "R-MMU-1234176", "R-BTA-3214841", "R-RNO-3214841", "R-RNO-6804760", "R-RNO-5689880", "R-MMU-5689880", "R-HSA-9827857", "R-CEL-1234176", "R-DRE-3214841", "R-HSA-3214841", "R-HSA-9733709", "R-HSA-5601884", "R-HSA-1234176"], "pathways": ["R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-DRE-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-SPO-3214841:r:PKMTs methylate histone lysines", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-3214841:r:PKMTs methylate histone lysines", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9827857:r:Specification of primordial germ cells", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Domain"}, "IPR002895": {"description": "Paramecium surface antigen", "go_ids": [], "go_terms": [], "name": "Paramecium_SA", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR002896": {"description": "Herpesvirus glycoprotein D/GG/GX domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Herpes_glycop_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002898": {"description": "MotA/TolQ/ExbB proton channel", "go_ids": [], "go_terms": [], "name": "MotA_ExbB_proton_chnl", "pathway_ids": ["R-HSA-9638334", "R-HSA-9927020", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9927020:r:Heme assimilation", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR002900": {"description": "Domain of unknown function DUF38/FTH, Caenorhabditis species", "go_ids": [], "go_terms": [], "name": "DUF38/FTH_CAE_spp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002901": {"description": "Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain", "go_ids": ["GO:0004040"], "go_terms": ["GO:0004040:amidase activity:F"], "name": "MGlyc_endo_b_GlcNAc-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002902": {"description": "Gnk2-homologous domain", "go_ids": [], "go_terms": [], "name": "GNK2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002903": {"description": "Ribosomal RNA small subunit methyltransferase H", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "RsmH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002904": {"description": "Lysine-tRNA ligase", "go_ids": ["GO:0000166", "GO:0004824", "GO:0005524", "GO:0005737", "GO:0006430"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004824:lysine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006430:lysyl-tRNA aminoacylation:P"], "name": "Lys-tRNA-ligase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002905": {"description": "tRNA methyltransferase, Trm1", "go_ids": ["GO:0016423", "GO:0003723", "GO:0008033"], "go_terms": ["GO:0016423:tRNA (guanine) methyltransferase activity:F", "GO:0003723:RNA binding:F", "GO:0008033:tRNA processing:P"], "name": "Trm1", "pathway_ids": ["PWY-6829", "R-HSA-6782315"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR002906": {"description": "Small ribosomal subunit protein eS31", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eS31", "pathway_ids": ["R-HSA-174178", "R-HSA-9604323", "R-BTA-5689880", "R-MMU-9770562", "R-HSA-8951664", "R-HSA-9010553", "R-MMU-6804756", "R-DME-937072", "R-HSA-69231", "R-DME-5696394", "R-BTA-6804757", "R-MMU-110314", "R-MMU-5689880", "R-BTA-6804756", "R-GGA-68949", "R-BTA-5696397", "R-RNO-8854050", "R-BTA-8951664", "R-DME-1169091", "R-HSA-3769402", "R-MMU-6782135", "R-MMU-8856825", "R-BTA-110312", "R-HSA-349425", "R-BTA-8941858", "R-DME-4641258", "R-MMU-9010553", "R-HSA-936440", "R-HSA-2559582", "R-HSA-1169408", "R-HSA-174184", "R-MMU-174048", "R-GGA-9861718", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-RNO-6804756", "R-HSA-175474", "R-BTA-5696395", "R-RNO-9648002", "R-BTA-168638", "R-DME-917729", "R-DME-68949", "R-DME-8856825", "R-GGA-2173788", "R-BTA-5689896", "R-HSA-8948747", "R-HSA-382556", "R-HSA-8852276", "R-BTA-5689877", "R-HSA-156902", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-9645460", "R-HSA-9929356", "R-DME-5205685", "R-BTA-909733", "R-RNO-5658442", "R-BTA-5685942", "R-RNO-5610785", "R-MMU-983168", "R-RNO-5675482", "R-GGA-201681", "R-GGA-182971", "R-DME-5654726", "R-GGA-9762114", "R-RNO-9861718", "R-DME-68867", "R-HSA-975163", "R-HSA-5675221", "R-GGA-5689901", "R-MMU-8856828", "R-HSA-9646399", "R-RNO-9758274", "R-HSA-2559580", "R-RNO-5668541", "R-BTA-9755511", "R-HSA-912631", "R-GGA-5654733", "R-HSA-75815", "R-HSA-9918487", "R-RNO-110314", "R-MMU-8948751", "R-RNO-8866654", "R-DME-8948751", "R-RNO-4641263", "R-BTA-201681", "R-HSA-72695", "R-RNO-912631", "R-MMU-937042", "R-GGA-5675221", "R-DME-8849469", "R-HSA-8863795", "R-BTA-1169091", "R-DME-5655862", "R-BTA-69481", "R-HSA-450302", "R-DME-9664873", "R-DME-5676590", "R-BTA-110314", "R-HSA-9013507", "R-HSA-2691232", "R-MMU-909733", "R-GGA-9766229", "R-GGA-1227892", "R-HSA-9931295", "R-GGA-433871", "R-HSA-5607761", "R-RNO-5656121", "R-HSA-205043", "R-MMU-9932298", "R-RNO-5696395", "R-RNO-975163", "R-HSA-9758274", "R-MMU-8948747", "R-HSA-72706", "R-MMU-201681", "R-BTA-5693565", "R-GGA-5654726", "R-DME-450302", "R-GGA-9954716", "R-RNO-209543", "R-HSA-8866654", "R-RNO-6804757", "R-MMU-4641258", "R-HSA-6804756", "R-HSA-909733", "R-GGA-6804760", "R-RNO-936440", "R-GGA-179409", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-BTA-6782210", "R-BTA-205043", "R-MMU-9766229", "R-RNO-69481", "R-HSA-9680350", "R-HSA-174154", "R-GGA-187577", "R-HSA-9833109", "R-GGA-9646399", "R-RNO-1234176", "R-RNO-5632684", "R-RNO-9932298", "R-MMU-450302", "R-GGA-5685942", "R-MMU-9645460", "R-RNO-174178", "R-HSA-156827", "R-DME-2565942", "R-RNO-450321", "R-MMU-5357956", "R-RNO-5654727", "R-MMU-174178", "R-GGA-5684264", "R-DME-450321", "R-BTA-9010553", "R-BTA-936440", "R-BTA-209543", "R-RNO-9645460", "R-HSA-2173795", "R-BTA-445989", "R-HSA-6782210", "R-GGA-1227882", "R-GGA-936964", "R-HSA-9762114", "R-HSA-195253", "R-HSA-9706369", "R-MMU-936964", "R-GGA-69601", "R-BTA-187577", "R-HSA-9770562", "R-GGA-8856825", "R-HSA-4641263", "R-GGA-9020702", "R-GGA-901032", "R-DME-8939236", "R-DME-2173795", "R-HSA-6807004", "R-HSA-1358803", "R-RNO-174113", "R-RNO-9824878", "R-BTA-9645460", "R-HSA-8866427", "R-MMU-5656121", "R-RNO-187577", "R-MMU-174184", "R-HSA-8856825", "R-MMU-5654727", "R-GGA-69017", "R-DME-9020702", "R-RNO-69017", "R-HSA-2173788", "R-MMU-937041", "R-BTA-5357905", "R-BTA-110320", "R-DME-5689880", "R-MMU-1253288", "R-RNO-201681", "R-RNO-110312", "R-GGA-8866654", "R-RNO-2559582", "R-HSA-5689896", "R-HSA-9828211", "R-HSA-8856828", "R-BTA-202424", "R-MMU-110320", "R-MMU-5689901", "R-MMU-2122948", "R-DME-912631", "R-RNO-5357905", "R-MMU-5205685", "R-MMU-2565942", "R-HSA-936964", "R-HSA-937041", "R-MMU-5696394", "R-HSA-450408", "R-RNO-450408", "R-GGA-209560", "R-DME-5654727", "R-HSA-211733", "R-HSA-9956593", "R-HSA-9708530", "R-MMU-8866654", "R-HSA-532668", "R-DME-4641257", "R-DME-432524", "R-GGA-437980", "R-RNO-975144", "R-GGA-8948751", "R-MMU-2173796", "R-MMU-3134975", "R-RNO-9705462", "R-RNO-5675221", "R-RNO-936964", "R-HSA-162588", "R-MMU-1234176", "R-RNO-6804760", "R-GGA-110312", "R-GGA-909733", "R-MMU-5357905", "R-BTA-69017", "R-GGA-9931269", "R-HSA-179409", "R-DME-9010553", "R-BTA-349425", "R-GGA-5689877", "R-DME-5689901", "R-DME-202424", "R-DME-187577", "R-HSA-201681", "R-MMU-187577", "R-BTA-9931295", "R-RNO-937072", "R-GGA-9755511", "R-HSA-3785653", "R-BTA-4608870", "R-BTA-5676590", "R-MMU-349425", "R-MMU-5693565", "R-DME-9770562", "R-BTA-2871837", "R-DME-174084", "R-GGA-6807004", "R-GGA-6804756", "R-BTA-174154", "R-RNO-2565942", "R-MMU-2672351", "R-DME-9929491", "R-BTA-8866427", "R-RNO-8856828", "R-DME-8863795", "R-BTA-209560", "R-GGA-1295596", "R-GGA-532668", "R-MMU-5696400", "R-BTA-3134975", "R-RNO-937041", "R-BTA-8849469", "R-GGA-912631", "R-GGA-9929491", "R-BTA-5655862", "R-MMU-209560", "R-HSA-5654726", "R-BTA-5696394", "R-RNO-9755511", "R-MMU-5675482", "R-MMU-5656169", "R-DME-5696395", "R-DME-174184", "R-HSA-72764", "R-BTA-9929356", "R-BTA-4641263", "R-MMU-5676590", "R-GGA-9954709", "R-RNO-5685942", "R-MMU-6783310", "R-GGA-5689880", "R-GGA-8866427", "R-RNO-68867", "R-HSA-5357956", "R-BTA-5656121", "R-DME-9932298", "R-RNO-9762114", "R-RNO-5654733", "R-BTA-9954709", "R-DME-6782210", "R-GGA-917729", "R-HSA-9725370", "R-HSA-937039", "R-HSA-5358346", "R-HSA-8849469", "R-BTA-174113", "R-GGA-9645460", "R-MMU-5632684", "R-RNO-9020702", "R-MMU-4641263", "R-GGA-450408", "R-BTA-5610785", "R-MMU-2467813", "R-HSA-9932298", "R-MMU-2173791", "R-BTA-9824878", "R-HSA-6781823", "R-MMU-8951664", "R-BTA-9033241", "R-DME-174113", "R-GGA-8854050", "R-MMU-9954716", "R-GGA-9932298", "R-MMU-445989", "R-BTA-9758274", "R-RNO-174154", "R-GGA-382556", "R-BTA-5675482", "R-DME-8948747", "R-MMU-9929356", "R-HSA-5205685", "R-GGA-5357956", "R-BTA-901032", "R-DME-9762114", "R-HSA-69481", "R-BTA-174084", "R-GGA-9824878", "R-BTA-2559582", "R-BTA-9648002", "R-HSA-5675482", "R-BTA-9708530", "R-BTA-5358346", "R-GGA-434131", "R-RNO-8939236", "R-RNO-2173791", "R-MMU-9708530", "R-HSA-180585", "R-GGA-68867", "R-RNO-450302", "R-BTA-8948747", "R-DME-209447", "R-RNO-168638", "R-RNO-2467813", "R-BTA-9646399", "R-DME-5607764", "R-HSA-9954714", "R-DME-2871837", "R-RNO-2559585", "R-DME-8941858", "R-MMU-8863795", "R-DME-937042", "R-GGA-351465", "R-BTA-382556", "R-MMU-9648002", "R-MMU-110312", "R-BTA-2173796", "R-GGA-5655862", "R-HSA-192823", "R-HSA-2565942", "R-GGA-174154", "R-HSA-9636383", "R-RNO-5610780", "R-MMU-937039", "R-BTA-5654733", "R-GGA-353303", "R-GGA-8939236", "R-GGA-8939902", "R-GGA-2122948", "R-DME-5689603", "R-DME-216167", "R-MMU-901032", "R-MMU-5658442", "R-MMU-168638", "R-HSA-174084", "R-GGA-2467813", "R-MMU-4608870", "R-BTA-5610780", "R-DME-975144", "R-RNO-8856825", "R-DME-5675482", "R-GGA-6804757", "R-HSA-69601", "R-HSA-72689", "R-HSA-983168", "R-MMU-9033241", "R-BTA-9861718", "R-GGA-4641263", "R-GGA-174048", "R-GGA-5654732", "R-HSA-9706377", "R-BTA-5689603", "R-BTA-8856825", "R-RNO-2559580", "R-RNO-8941858", "R-HSA-69017", "R-HSA-917937", "R-HSA-9692916", "R-RNO-1169091", "R-RNO-9766229", "R-HSA-9014325", "R-HSA-450321", "R-MMU-5696395", "R-DME-8939902", "R-HSA-5693607", "R-RNO-5689877", "R-HSA-6804757", "R-BTA-937041", "R-RNO-205043", "R-BTA-5693607", "R-GGA-6782135", "R-DME-4608870", "R-BTA-9706369", "R-RNO-8866427", "R-RNO-9929356", "R-BTA-8863795", "R-RNO-6782210", "R-GGA-8856828", "R-GGA-450302", "R-HSA-209560", "R-RNO-5205685", "R-MMU-209543", "R-HSA-9918432", "R-BTA-5687128", "R-HSA-5678895", "R-BTA-1358803", "R-HSA-9735869", "R-HSA-4641258", "R-MMU-2559580", "R-RNO-174184", "R-BTA-4641258", "R-GGA-5656169", "R-HSA-4608870", "R-BTA-8866652", "R-MMU-4641257", "R-RNO-3134975", "R-BTA-9770562", "R-HSA-975110", "R-GGA-1253288", "R-MMU-2173788", "R-BTA-937039", "R-BTA-5654726", "R-MMU-5610780", "R-DME-9954709", "R-HSA-977225", "R-RNO-1295596", "R-DME-8866427", "R-BTA-5654727", "R-RNO-2173788", "R-MMU-9755511", "R-MMU-9954709", "R-BTA-937072", "R-BTA-2672351", "R-HSA-2871837", "R-RNO-5689603", "R-MMU-9931295", "R-RNO-8849469", "R-GGA-8863795", "R-HSA-5362768", "R-GGA-174113", "R-RNO-8852276", "R-GGA-5668541", "R-BTA-6807004", "R-BTA-174178", "R-RNO-937039", "R-MMU-5655862", "R-BTA-8948751", "R-BTA-3769402", "R-HSA-9013973", "R-HSA-2173791", "R-RNO-9929491", "R-BTA-5205685", "R-HSA-2894862", "R-GGA-434001", "R-RNO-110320", "R-HSA-9754678", "R-HSA-5632684", "R-BTA-8854050", "R-HSA-9683683", "R-HSA-8876493", "R-GGA-5696395", "R-RNO-5607764", "R-GGA-2672351", "R-MMU-5654733", "R-BTA-5607764", "R-HSA-69541", "R-RNO-182971", "R-GGA-75815", "R-GGA-937042", "R-RNO-6781823", "R-GGA-5689603", "R-GGA-937041", "R-HSA-5689880", "R-BTA-1234176", "R-GGA-110314", "R-RNO-5693565", "R-MMU-69017", "R-RNO-5655862", "R-DME-5654732", "R-RNO-5689901", "R-RNO-8863795", "R-BTA-450321", "R-DME-2467813", "R-RNO-937042", "R-BTA-936964", "R-DME-1295596", "R-BTA-2173795", "R-GGA-5632684", "R-BTA-5689901", "R-HSA-1234176", "R-RNO-4641258", "R-MMU-6804760", "R-DME-2559582", "R-HSA-9931269", "R-HSA-2408557", "R-MMU-975144", "R-DME-174048", "R-HSA-182971", "R-RNO-5654732", "R-MMU-68867", "R-BTA-182971", "R-BTA-6782135", "R-DME-209461", "R-MMU-450321", "R-BTA-2173788", "R-HSA-6804760", "R-HSA-72702", "R-BTA-5684264", "R-DME-9861718", "R-GGA-937072", "R-GGA-9013507", "R-BTA-5675221", "R-DME-75815", "R-GGA-209543", "R-BTA-917937", "R-HSA-5696394", "R-DME-69601", "R-GGA-2559582", "R-HSA-2644606", "R-DME-182971", "R-MMU-5675221", "R-DME-69017", "R-DME-983168", "R-GGA-983168", "R-GGA-9758274", "R-DME-1358803", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-6781827", "R-HSA-2467813", "R-HSA-168928", "R-HSA-937042", "R-BTA-195253", "R-HSA-9824878", "R-RNO-69601", "R-GGA-5610785", "R-HSA-9861718", "R-DME-937039", "R-MMU-9664873", "R-MMU-8939236", "R-MMU-917937", "R-RNO-4641257", "R-MMU-532668", "R-MMU-9762114", "R-BTA-5696400", "R-HSA-5689877", "R-MMU-205043", "R-GGA-349425", "R-GGA-9033241", "R-MMU-195253", "R-MMU-202424", "R-BTA-8856828", "R-MMU-382556", "R-BTA-9705462", "R-GGA-6783310", "R-DME-209360", "R-BTA-5632684", "R-DME-5357905", "R-RNO-9664873", "R-BTA-9931269", "R-MMU-6804757", "R-RNO-75815", "R-MMU-1169091", "R-BTA-1295596", "R-HSA-72649", "R-DME-8854050", "R-RNO-6807004", "R-MMU-8939902", "R-RNO-9770562", "R-GGA-1169091", "R-HSA-5696400", "R-BTA-917729", "R-HSA-8875360", "R-HSA-8939236", "R-BTA-2122948", "R-BTA-983168", "R-BTA-69231", "R-RNO-5654726", "R-MMU-5607764", "R-DME-6781823", "R-GGA-9664873", "R-DME-69231", "R-BTA-5668541", "R-BTA-9020702", "R-GGA-3134975", "R-GGA-5610780", "R-HSA-202424", "R-DME-975163", "R-HSA-9033241", "R-HSA-9637628", "R-RNO-2871837", "R-HSA-9633012", "R-RNO-917729", "R-MMU-2173795", "R-DME-110314", "R-RNO-68949", "R-HSA-9020702", "R-MMU-450408", "R-RNO-8948751", "R-HSA-168638", "R-MMU-917729", "R-MMU-8941858", "R-DME-2173788", "R-MMU-174154", "R-MMU-9861718", "R-MMU-9020702", "R-MMU-937072", "R-RNO-382556", "R-HSA-5693565", "R-RNO-5687128", "R-MMU-8866652", "R-BTA-975144", "R-MMU-5689896", "R-MMU-69481", "R-DME-5689896", "R-GGA-1358803", "R-RNO-9033241", "R-MMU-75815", "R-HSA-5684264", "R-HSA-2979096", "R-RNO-5696397", "R-HSA-168927", "R-MMU-5689877", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-HSA-8854050", "R-RNO-5656169", "R-BTA-5607761", "R-HSA-5610783", "R-DME-6782135", "R-HSA-2122947", "R-MMU-174084", "R-BTA-68867", "R-GGA-8866652", "R-HSA-9929491", "R-HSA-5654727", "R-MMU-174113", "R-RNO-174048", "R-MMU-2559582", "R-DME-1253288", "R-HSA-6783310", "R-RNO-5696394", "R-DME-5675221", "R-DME-9648002", "R-RNO-5689880", "R-RNO-179409", "R-MMU-9646399", "R-HSA-1295596", "R-RNO-8951664", "R-HSA-5696395", "R-BTA-8866654", "R-GGA-195253", "R-DME-1234176", "R-HSA-1236974", "R-HSA-174048", "R-MMU-5687128", "R-BTA-532668", "R-HSA-9648002", "R-RNO-5358346", "R-DME-5358346", "R-HSA-9664873", "R-RNO-2173796", "R-GGA-975956", "R-HSA-68949", "R-HSA-9954716", "R-HSA-9705671", "R-HSA-5685942", "R-BTA-5357956", "R-GGA-205043", "R-MMU-8852276", "R-RNO-901032", "R-BTA-68949", "R-MMU-179409", "R-HSA-2672351", "R-RNO-8866652", "R-MMU-68949", "R-GGA-8951664", "R-RNO-1253288", "R-RNO-69541", "R-DME-8866652", "R-MMU-6781823", "R-BTA-6781823", "R-HSA-5357905", "R-GGA-8941858", "R-MMU-9013507", "R-GGA-9954714", "R-BTA-5656169", "R-GGA-9770562", "R-HSA-9615710", "R-RNO-349425", "R-BTA-174184", "R-DME-917937", "R-MMU-9824878", "R-MMU-5693607", "R-GGA-975163", "R-BTA-8939236", "R-HSA-5610780", "R-MMU-912631", "R-DME-8866654", "R-BTA-9954716", "R-GGA-5656121", "R-MMU-9706369", "R-DME-9646399", "R-GGA-5696394", "R-MMU-5607761", "R-DME-901032", "R-RNO-69231", "R-HSA-917729", "R-DME-445989", "R-HSA-8939902", "R-MMU-5654726", "R-HSA-975957", "R-DME-5696400", "R-DME-174178", "R-RNO-5696400", "R-RNO-9646399", "R-MMU-6807004", "R-DME-2173796", "R-RNO-3769402", "R-GGA-1799339", "R-GGA-9929356", "R-RNO-195253", "R-DME-5654733", "R-RNO-6783310", "R-MMU-2559585", "R-MMU-182971", "R-GGA-433822", "R-GGA-5689896", "R-DME-209560", "R-HSA-5696397", "R-DME-8951664", "R-BTA-179409", "R-GGA-5654727", "R-HSA-9766229", "R-GGA-1234176", "R-MMU-1295596", "R-HSA-5655862", "R-BTA-9929491", "R-HSA-8866652", "R-RNO-9954716", "R-MMU-9929491", "R-MMU-5654732", "R-BTA-9932298", "R-GGA-6781823", "R-GGA-69231", "R-GGA-72706", "R-GGA-3769402", "R-HSA-68867", "R-MMU-5684264", "R-DME-174154", "R-GGA-110320", "R-GGA-2173796", "R-GGA-1227888", "R-HSA-975144", "R-BTA-450408", "R-GGA-5675482", "R-DME-110320", "R-HSA-8941858", "R-RNO-209560", "R-HSA-5654732", "R-DME-179409", "R-BTA-1253288", "R-GGA-450321", "R-GGA-6782210", "R-MMU-9705462", "R-DME-9755511", "R-RNO-9931295", "R-MMU-2871837", "R-RNO-1358803", "R-HSA-6791226", "R-DME-5610785", "R-RNO-174084", "R-HSA-5689603", "R-MMU-6782210", "R-HSA-5654733", "R-RNO-983168", "R-GGA-174084", "R-HSA-445989", "R-MMU-69231", "R-DME-2122948", "R-DME-6804757", "R-DME-5656121", "R-GGA-5358346", "R-HSA-5676590", "R-MMU-69541", "R-DME-9954716", "R-HSA-975956", "R-RNO-2173795", "R-GGA-5687128", "R-HSA-3322077", "R-HSA-4641257", "R-RNO-202424", "R-GGA-5693565", "R-HSA-174113", "R-HSA-174490", "R-MMU-975163", "R-BTA-9762114", "R-GGA-2173795", "R-RNO-5607761", "R-HSA-5656121", "R-GGA-5696400", "R-GGA-4641257", "R-HSA-1799339", "R-HSA-9694493", "R-BTA-937042", "R-GGA-8849469", "R-RNO-917937", "R-DME-5689877", "R-HSA-9755511", "R-RNO-9013507", "R-RNO-9931269", "R-HSA-110312", "R-BTA-912631", "R-DME-2173791", "R-DME-3769402", "R-DME-3134975", "R-GGA-8948747", "R-HSA-1169091", "R-GGA-174178", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-8866427", "R-RNO-532668", "R-HSA-1253288", "R-MMU-9931269", "R-BTA-6783310", "R-HSA-3134975", "R-RNO-445989", "R-HSA-9613829", "R-HSA-8948751", "R-RNO-5689896", "R-MMU-5696397", "R-DME-450408", "R-RNO-2122948", "R-HSA-110314", "R-BTA-8939902", "R-BTA-9766229", "R-HSA-5689901", "R-GGA-9931295", "R-HSA-187577", "R-HSA-901032", "R-HSA-2122948", "R-GGA-573298", "R-DME-382556", "R-HSA-209543", "R-GGA-4641258", "R-DME-5610780", "R-HSA-2559585", "R-DME-195253", "R-MMU-69601", "R-RNO-2672351", "R-BTA-5654732", "R-DME-110312", "R-HSA-1236382", "R-DME-5607761", "R-GGA-69541", "R-DME-8856828", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5656169", "R-HSA-937072", "R-HSA-5607764", "R-HSA-2173796", "R-GGA-353299", "R-MMU-1358803", "R-RNO-8948747", "R-MMU-3769402", "R-RNO-4608870", "R-GGA-5696397", "R-MMU-8849469", "R-BTA-9664873", "R-DME-9033241", "R-BTA-2173791", "R-RNO-6782135", "R-RNO-5684264", "R-BTA-174048", "R-GGA-5357905", "R-BTA-6804760", "R-DME-532668", "R-DME-538864", "R-GGA-2173791", "R-GGA-975957", "R-GGA-174184", "R-HSA-5668541", "R-DME-5632684", "R-HSA-5687128", "R-DME-432395", "R-BTA-450302", "R-RNO-909733", "R-HSA-9705462", "R-RNO-5357956", "R-MMU-936440", "R-MMU-9758274", "R-GGA-437986", "R-HSA-110320", "R-BTA-975163"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-68949:r:Orc1 removal from chromatin", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-8951664:r:Neddylation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-110312:r:Translesion synthesis by REV1", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-9861718:r:Regulation of pyruvate metabolism", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-9648002:r:RAS processing", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-5689877:r:Josephin domain DUBs", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-GGA-201681:r:TCF dependent signaling in response to WNT", "R-GGA-182971:r:EGFR downregulation", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-GGA-5689901:r:Metalloprotease DUBs", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-912631:r:Regulation of signaling by CBL", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-DME-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DME-5655862:r:Translesion synthesis by POLK", "R-BTA-69481:r:G2/M Checkpoints", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-9664873:r:Pexophagy", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-9766229:r:Degradation of CDH1", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-GGA-433871:r:TRAF6 mediated induction of proinflammatory cytokines", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-GGA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-GGA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-GGA-9646399:r:Aggrephagy", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-GGA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9770562:r:mRNA Polyadenylation", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-9020702:r:Interleukin-1 signaling", "R-GGA-901032:r:ER Quality Control Compartment (ERQC)", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-GGA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-RNO-110312:r:Translesion synthesis by REV1", "R-GGA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-912631:r:Regulation of signaling by CBL", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-209560:r:NF-kB is activated and signals survival", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-GGA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-5689877:r:Josephin domain DUBs", "R-DME-5689901:r:Metalloprotease DUBs", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-6807004:r:Negative regulation of MET activity", "R-GGA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-GGA-1295596:r:Spry regulation of FGF signaling", "R-GGA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-912631:r:Regulation of signaling by CBL", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-GGA-5689880:r:Ub-specific processing proteases", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-GGA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-BTA-9033241:r:Peroxisomal protein import", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-GGA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-GGA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-382556:r:ABC-family proteins mediated transport", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-DME-8948747:r:Regulation of PTEN localization", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-GGA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-901032:r:ER Quality Control Compartment (ERQC)", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-9648002:r:RAS processing", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-GGA-68867:r:Assembly of the pre-replicative complex", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-8948747:r:Regulation of PTEN localization", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-9646399:r:Aggrephagy", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-9648002:r:RAS processing", "R-MMU-110312:r:Translesion synthesis by REV1", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-192823:r:Viral mRNA Translation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-GGA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-GGA-353303:r:Nucleotide Excision Repair", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-GGA-8939902:r:Regulation of RUNX2 expression and activity", "R-GGA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-5689603:r:UCH proteinases", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5689877:r:Josephin domain DUBs", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-GGA-6782135:r:Dual incision in TC-NER", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-9706369:r:Negative regulation of FLT3", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-GGA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-4641258:r:Degradation of DVL", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-4641258:r:Degradation of DVL", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-4641257:r:Degradation of AXIN", "R-RNO-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-GGA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-BTA-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-BTA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-2672351:r:Stimuli-sensing channels", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-GGA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-GGA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-6807004:r:Negative regulation of MET activity", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9683683:r:Maturation of protein E", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-GGA-2672351:r:Stimuli-sensing channels", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-69541:r:Stabilization of p53", "R-RNO-182971:r:EGFR downregulation", "R-GGA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-GGA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-5689603:r:UCH proteinases", "R-GGA-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DME-2467813:r:Separation of Sister Chromatids", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-GGA-5632684:r:Hedgehog 'on' state", "R-BTA-5689901:r:Metalloprotease DUBs", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-BTA-182971:r:EGFR downregulation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-GGA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-GGA-209543:r:p75NTR recruits signalling complexes", "R-BTA-917937:r:Iron uptake and transport", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-GGA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-DME-182971:r:EGFR downregulation", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-9758274:r:Regulation of NF-kappa B signaling", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-MMU-9664873:r:Pexophagy", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-917937:r:Iron uptake and transport", "R-RNO-4641257:r:Degradation of AXIN", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-5689877:r:Josephin domain DUBs", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-GGA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-9033241:r:Peroxisomal protein import", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-6783310:r:Fanconi Anemia Pathway", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-RNO-9664873:r:Pexophagy", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-HSA-72649:r:Translation initiation complex formation", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-9770562:r:mRNA Polyadenylation", "R-GGA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-69231:r:Cyclin D associated events in G1", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-9664873:r:Pexophagy", "R-DME-69231:r:Cyclin D associated events in G1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-9020702:r:Interleukin-1 signaling", "R-GGA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-GGA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-202424:r:Downstream TCR signaling", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", 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signaling", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-538864:r:Degradation of CRY", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-GGA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-432395:r:Degradation of TIM", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Domain"}, "IPR002908": {"description": "Frataxin/CyaY", "go_ids": ["GO:0016226", "GO:0008199"], "go_terms": ["GO:0016226:iron-sulfur cluster assembly:P", "GO:0008199:ferric iron binding:F"], "name": "Frataxin/CyaY", "pathway_ids": ["R-HSA-1362409", "R-HSA-9865881", "R-HSA-9854311", "R-RNO-1268020", "R-BTA-9854311", "R-SCE-1362409", "R-RNO-1362409", "R-SPO-9854311", "R-DDI-1362409", "R-SCE-9865881", "R-CEL-1362409", "R-SPO-1268020", "R-DME-9865881", "R-MMU-9865881", "R-SPO-9865881", "R-RNO-9854311", "R-DME-9854311", "R-MMU-9854311", "R-HSA-1268020", "R-DDI-9865881", "R-MMU-1362409", "R-MMU-1268020", "R-BTA-1268020", "R-CEL-9854311", "R-DDI-9854311", "R-RNO-9865881", "R-BTA-9865881", "R-BTA-1362409", "R-SCE-1268020", "R-SPO-1362409", "R-SCE-9854311", "R-DME-1362409"], "pathways": 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"R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-1268020:r:Mitochondrial protein import", "R-DDI-9865881:r:Complex III assembly", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-1268020:r:Mitochondrial protein import", "R-BTA-1268020:r:Mitochondrial protein import", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-9865881:r:Complex III assembly", "R-BTA-9865881:r:Complex III assembly", "R-BTA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SCE-1268020:r:Mitochondrial protein import", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-1362409:r:Mitochondrial iron-sulfur cluster biogenesis"], "type": "Family"}, "IPR002909": {"description": "IPT domain", "go_ids": [], "go_terms": [], "name": "IPT_dom", "pathway_ids": 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"R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-264876:r:Insulin processing", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-MMU-416700:r:Other semaphorin interactions", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-RNO-264876:r:Insulin processing", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-CEL-416700:r:Other semaphorin interactions", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-264876:r:Insulin processing", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-8852405:r:Signaling by MST1", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-8875791:r:MET activates STAT3", "R-CEL-264876:r:Insulin processing", "R-SSC-6807004:r:Negative regulation of MET activity", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-DDI-3295583:r:TRP channels", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-6806942:r:MET Receptor Activation", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-SSC-8875791:r:MET activates STAT3", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-SSC-8851805:r:MET activates RAS signaling", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-264876:r:Insulin processing", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-4755510:r:SUMOylation of immune response proteins", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-5673000:r:RAF activation", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-6806942:r:MET Receptor Activation", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-SSC-8875656:r:MET receptor recycling", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-RNO-8875656:r:MET receptor recycling", "R-MMU-448706:r:Interleukin-1 processing", "R-RNO-8851805:r:MET activates RAS signaling", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-SSC-6806942:r:MET Receptor Activation", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-416700:r:Other semaphorin interactions", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-8865999:r:MET activates PTPN11"], "type": "Domain"}, "IPR002910": {"description": "Floricaula/leafy protein", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "FLO_LFY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002912": {"description": "ACT domain", "go_ids": [], "go_terms": [], "name": "ACT_dom", "pathway_ids": ["R-HSA-2160456", "R-RNO-8964208", "R-HSA-209931", "R-DDI-8964208", "R-HSA-8964208", "R-DDI-209931", "R-CEL-8964208", "R-BTA-8964208", "R-HSA-9031628", "R-DDI-209905", "R-RNO-209931", "R-MMU-209931", "R-DME-8964208", "R-MMU-8964208"], "pathways": ["R-HSA-2160456:r:Phenylketonuria", "R-RNO-8964208:r:Phenylalanine metabolism", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-DDI-8964208:r:Phenylalanine metabolism", "R-HSA-8964208:r:Phenylalanine metabolism", "R-DDI-209931:r:Serotonin and melatonin biosynthesis", "R-CEL-8964208:r:Phenylalanine metabolism", "R-BTA-8964208:r:Phenylalanine metabolism", "R-HSA-9031628:r:NGF-stimulated transcription", "R-DDI-209905:r:Catecholamine biosynthesis", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-209931:r:Serotonin and melatonin biosynthesis", "R-DME-8964208:r:Phenylalanine metabolism", "R-MMU-8964208:r:Phenylalanine metabolism"], "type": "Domain"}, "IPR002913": {"description": "START domain", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "START_lipid-bd_dom", "pathway_ids": ["R-RNO-9013026", "R-MMU-9837999", "R-MMU-9013106", "R-RNO-1483191", "R-MMU-8980692", "R-MMU-1483191", "R-RNO-8980692", "R-RNO-9013149", "R-MMU-9013148", "R-HSA-9013106", "R-MMU-2142789", "R-DDI-8951664", "R-MMU-196108", "R-RNO-77289", "R-BTA-9837999", "R-HSA-9013148", "R-HSA-2142789", "R-HSA-9837999", "R-RNO-9013406", "R-RNO-9013106", "R-DRE-1660661", "R-HSA-77289", "R-HSA-196108", "R-DRE-196108", "R-BTA-77289", "R-RNO-9013148", "R-RNO-9837999", "R-HSA-1660661", "R-BTA-159418", "R-RNO-196108", "R-BTA-1660661", "R-DRE-9837999", "R-DDI-983168", "R-HSA-9013149", "R-HSA-1483191", "R-HSA-8980692", "R-MMU-9013406", "R-BTA-196108", "R-MMU-9013026", "R-MMU-77289", "R-HSA-9013026", "R-HSA-159418", "R-HSA-9013406", "R-BTA-1483191", "R-MMU-9013149", "R-MMU-159418"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-1483191:r:Synthesis of PC", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-1483191:r:Synthesis of PC", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DDI-8951664:r:Neddylation", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-DRE-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-DRE-196108:r:Pregnenolone biosynthesis", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-BTA-159418:r:Recycling of bile acids and salts", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1483191:r:Synthesis of PC", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-BTA-196108:r:Pregnenolone biosynthesis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-BTA-1483191:r:Synthesis of PC", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-159418:r:Recycling of bile acids and salts"], "type": "Domain"}, "IPR002914": {"description": "Pollen allergen Poa p IX/Phl p VI", "go_ids": [], "go_terms": [], "name": "Poa_pIX/Phl_pVI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002915": {"description": "DeoC/FbaB/LacD aldolase", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "DeoC/FbaB/LacD_aldolase", "pathway_ids": ["PWY-7180", "PWY-8060", "R-MMU-6798695", "R-MMU-71336", "R-BTA-6798695", "R-HSA-6798695", "R-HSA-71336", "R-CEL-71336", "R-BTA-71336", "R-CEL-6798695"], "pathways": ["PWY-7180:t:2-deoxy-alpha-D-ribose 1-phosphate degradation", "PWY-8060:t:2-deoxy-D-ribose degradation I", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-71336:r:Pentose phosphate pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-71336:r:Pentose phosphate pathway", "R-CEL-71336:r:Pentose phosphate pathway", "R-BTA-71336:r:Pentose phosphate pathway", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR002918": {"description": "Lipase EstA/Esterase EstB", "go_ids": ["GO:0016042", "GO:0016787"], "go_terms": ["GO:0016042:lipid catabolic process:P", "GO:0016787:hydrolase activity:F"], "name": "Lipase_EstA/Esterase_EstB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002919": {"description": "Trypsin Inhibitor-like, cysteine rich domain", "go_ids": [], "go_terms": [], "name": "TIL_dom", "pathway_ids": ["R-HSA-5083632", "R-MMU-163125", "R-HSA-5674135", "R-MMU-5674135", "R-HSA-6802952", "R-HSA-9845620", "R-HSA-977068", "R-MMU-913709", "R-HSA-140837", "R-HSA-430116", "R-MMU-76009", "R-MMU-430116", "R-HSA-9845622", "R-HSA-9845621", "R-MMU-372708", "R-HSA-114608", "R-HSA-76009", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-9846298", "R-HSA-5083625", "R-HSA-9672391", "R-MMU-977068", "R-HSA-5621480", "R-HSA-6802955", "R-HSA-9672393", "R-HSA-354192", "R-HSA-5083636", "R-HSA-6802948", "R-HSA-216083", "R-HSA-5083635", "R-HSA-9662361", "R-MMU-140837", "R-HSA-9845619", "R-HSA-354194", "R-MMU-354194", "R-HSA-163125", "R-HSA-75892", "R-RNO-5173214", "R-MMU-114608", "R-HSA-5173214", "R-MMU-5173214", "R-MMU-216083", "R-HSA-372708", "R-MMU-354192", "R-HSA-913709", "R-HSA-9656223"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-354192:r:Integrin signaling", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-114608:r:Platelet degranulation", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Domain"}, "IPR002921": {"description": "Fungal lipase-type domain", "go_ids": ["GO:0006629"], "go_terms": ["GO:0006629:lipid metabolic process:P"], "name": "Fungal_lipase-type", "pathway_ids": ["R-HSA-426048", "R-MMU-426048", "R-RNO-426048"], "pathways": ["R-HSA-426048:r:Arachidonate production from DAG", "R-MMU-426048:r:Arachidonate production from DAG", "R-RNO-426048:r:Arachidonate production from DAG"], "type": "Domain"}, "IPR002922": {"description": "Thiazole biosynthetic enzyme Thi4 family", "go_ids": [], "go_terms": [], "name": "Thi4_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002924": {"description": "Adenovirus small t-antigen, E1B 19kDa protein", "go_ids": ["GO:0033668"], "go_terms": ["GO:0033668:symbiont-mediated suppression of host apoptosis:P"], "name": "Adenovir_t-Ag_E1B_19kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002925": {"description": "Dienelactone hydrolase", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Dienelactn_hydro", "pathway_ids": ["R-RNO-211945", "R-HSA-211945", "R-XTR-211945", "R-MMU-211945"], "pathways": ["R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-XTR-211945:r:Phase I - Functionalization of compounds", "R-MMU-211945:r:Phase I - Functionalization of compounds"], "type": "Domain"}, "IPR002928": {"description": "Myosin tail", "go_ids": ["GO:0016459"], "go_terms": ["GO:0016459:myosin complex:C"], "name": "Myosin_tail", "pathway_ids": ["R-HSA-416572", "R-CEL-8980692", "R-HSA-5625900", "R-HSA-9662834", "R-MMU-2173791", "R-HSA-5625740", "R-MMU-445355", "R-DME-445355", "R-CEL-416482", "R-BTA-5627123", "R-RNO-2029482", "R-CEL-9013407", "R-CFA-2173791", "R-HSA-9662360", "R-CEL-3928662", "R-HSA-5655302", "R-DME-9013407", "R-RNO-390522", "R-HSA-445355", "R-DME-8980692", "R-HSA-2173791", "R-HSA-9662361", "R-HSA-9927432", "R-MMU-390522", "R-DME-3928662", "R-HSA-2029482", "R-DME-350480", "R-CEL-416572", "R-DME-9013422", "R-DME-5627117", "R-MMU-2029482", "R-XTR-2173791", "R-CEL-5627117", "R-DRE-2173791", "R-HSA-9703465", "R-DME-416572", "R-HSA-3928663", "R-HSA-5627123", "R-CEL-4420097", "R-HSA-1445148", "R-HSA-390522", "R-DME-416482", "R-DDI-5627123", "R-MMU-5627123", "R-HSA-9664422", "R-DME-4420097", "R-HSA-9725370", "R-HSA-5627117", "R-HSA-1839117"], "pathways": ["R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-9013407:r:RHOH GTPase cycle", "R-CFA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-DME-9013407:r:RHOH GTPase cycle", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-MMU-390522:r:Striated Muscle Contraction", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-DME-5627117:r:RHO GTPases Activate ROCKs", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-XTR-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-DRE-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-390522:r:Striated Muscle Contraction", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR002929": {"description": "Potato leaf roll virus readthrough protein", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "PLrV_ORF5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR002930": {"description": "Glycine cleavage system H-protein", "go_ids": ["GO:0019464", "GO:0005960"], "go_terms": ["GO:0019464:glycine decarboxylation via glycine cleavage system:P", "GO:0005960:glycine cleavage complex:C"], "name": "GCV_H", "pathway_ids": ["R-RNO-6783984", "R-SPO-9857492", "R-MMU-6783984", "R-BTA-6783984", "R-MMU-9857492", "R-DME-9857492", "R-HSA-6783984", "R-SCE-6783984", "R-DDI-6783984", "R-RNO-9857492", "R-SCE-9857492", "R-GGA-6783984", "R-GGA-9857492", "R-BTA-9857492", "R-DDI-9857492", "R-SPO-6783984", "R-DME-6783984", "R-HSA-9857492"], "pathways": ["R-RNO-6783984:r:Glycine degradation", "R-SPO-9857492:r:Protein lipoylation", "R-MMU-6783984:r:Glycine degradation", "R-BTA-6783984:r:Glycine degradation", "R-MMU-9857492:r:Protein lipoylation", "R-DME-9857492:r:Protein lipoylation", "R-HSA-6783984:r:Glycine degradation", "R-SCE-6783984:r:Glycine degradation", "R-DDI-6783984:r:Glycine degradation", "R-RNO-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-GGA-6783984:r:Glycine degradation", "R-GGA-9857492:r:Protein lipoylation", "R-BTA-9857492:r:Protein lipoylation", "R-DDI-9857492:r:Protein lipoylation", "R-SPO-6783984:r:Glycine degradation", "R-DME-6783984:r:Glycine degradation", "R-HSA-9857492:r:Protein lipoylation"], "type": "Family"}, "IPR002931": {"description": "Transglutaminase-like", "go_ids": [], "go_terms": [], "name": "Transglutaminase-like", "pathway_ids": ["R-HSA-532668", "R-HSA-114608", "R-RNO-6809371", "R-MMU-6809371", "R-HSA-6809371", "R-RNO-532668", "R-MMU-140875", "R-CEL-532668", "R-RNO-140875", "R-MMU-532668", "R-HSA-6785807", "R-HSA-140875", "R-DME-532668", "R-DRE-532668", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-114608:r:Platelet degranulation", "R-RNO-6809371:r:Formation of the cornified envelope", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR002932": {"description": "Glutamate synthase domain", "go_ids": ["GO:0015930", "GO:0016638", "GO:0097054"], "go_terms": ["GO:0015930:glutamate synthase activity:F", "GO:0016638:oxidoreductase activity, acting on the CH-NH2 group of donors:F", "GO:0097054:L-glutamate biosynthetic process:P"], "name": "Glu_synthdom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR002933": {"description": "Peptidase M20", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Peptidase_M20", "pathway_ids": ["R-XTR-9673163", "R-MMU-9753281", "R-RNO-174403", "R-RNO-9753281", "R-RNO-5423646", "R-DDI-9673163", "R-HSA-5423646", "R-HSA-9753281", "R-MMU-9673163", "R-SPO-9673163", "R-SCE-9673163", "R-SCE-174403", "R-HSA-9673163", "R-MMU-5423646", "R-HSA-174403", "R-BTA-174403", "R-MMU-174403", "R-SPO-174403", "R-HSA-5579007", "R-DDI-5423646", "R-SPO-9753281", "R-SCE-9753281", "R-DDI-9753281", "R-BTA-9753281", "R-DRE-9673163"], "pathways": ["R-XTR-9673163:r:Oleoyl-phe metabolism", "R-MMU-9753281:r:Paracetamol ADME", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-RNO-9753281:r:Paracetamol ADME", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-DDI-9673163:r:Oleoyl-phe metabolism", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-HSA-9753281:r:Paracetamol ADME", "R-MMU-9673163:r:Oleoyl-phe metabolism", "R-SPO-9673163:r:Oleoyl-phe metabolism", "R-SCE-9673163:r:Oleoyl-phe metabolism", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-HSA-9673163:r:Oleoyl-phe metabolism", "R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-HSA-5579007:r:Defective ACY1 causes encephalopathy", "R-DDI-5423646:r:Aflatoxin activation and detoxification", "R-SPO-9753281:r:Paracetamol ADME", "R-SCE-9753281:r:Paracetamol ADME", "R-DDI-9753281:r:Paracetamol ADME", "R-BTA-9753281:r:Paracetamol ADME", "R-DRE-9673163:r:Oleoyl-phe metabolism"], "type": "Family"}, "IPR002934": {"description": "Polymerase, nucleotidyl transferase domain", "go_ids": ["GO:0016779"], "go_terms": ["GO:0016779:nucleotidyltransferase activity:F"], "name": "Polymerase_NTP_transf_dom", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978", "R-HSA-9833110", "R-HSA-8983711", "R-HSA-909733", "R-HSA-877300"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-877300:r:Interferon gamma signaling"], "type": "Domain"}, "IPR002935": {"description": "Class I-like SAM-dependent O-methyltransferase", "go_ids": ["GO:0008171"], "go_terms": ["GO:0008171:O-methyltransferase activity:F"], "name": "SAM_O-MeTrfase", "pathway_ids": ["R-SPO-379398", "R-SPO-379397", "R-MMU-379397", "R-DRE-156581", "R-MMU-379398", "R-HSA-379397", "R-HSA-9679191", "R-MMU-156581", "R-HSA-379398", "R-SPO-156581", "R-BTA-379398", "R-BTA-156581", "R-BTA-379397", "R-RNO-379397", "R-RNO-379398", "R-DRE-379398", "R-RNO-156581", "R-HSA-156581", "R-DRE-379397"], "pathways": ["R-SPO-379398:r:Enzymatic 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COMT"], "type": "Family"}, "IPR002937": {"description": "Amine oxidase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Amino_oxidase", "pathway_ids": ["R-CEL-983231", "R-MMU-3214815", "R-MMU-181430", "R-MMU-351200", "R-RNO-9018519", "R-SPO-189451", "R-DDI-189451", "R-RNO-3214842", "R-RNO-983231", "R-HSA-8943724", "R-HSA-5579012", "R-DME-9764725", "R-RNO-380612", "R-HSA-9018519", "R-BTA-380612", "R-BTA-181430", "R-HSA-181430", "R-MMU-379401", "R-DME-9018519", "R-HSA-351200", "R-DME-5625886", "R-HSA-983231", "R-HSA-196807", "R-HSA-3214815", "R-HSA-9764725", "R-DRE-379401", "R-HSA-6785807", "R-MMU-141334", "R-RNO-196807", "R-HSA-379398", "R-MMU-9018519", "R-BTA-379398", "R-DME-141334", "R-RNO-9764725", "R-HSA-379401", "R-HSA-5689603", "R-DDI-181430", "R-DRE-380612", "R-DDI-8964208", "R-BTA-189451", "R-HSA-189451", "R-MMU-196807", "R-DDI-379398", "R-DDI-380612", "R-MMU-983231", "R-HSA-141334", "R-HSA-5625886", "R-DDI-379401", "R-DRE-181430", "R-RNO-3214815", "R-HSA-141333", "R-DME-3214815", "R-RNO-379398", "R-RNO-379397", "R-DRE-141333", "R-RNO-5625886", "R-MMU-3214842", "R-MMU-141333", "R-MMU-380612", "R-DME-983231", "R-MMU-5689603", "R-RNO-141333", "R-CEL-3214842", "R-HSA-9029569", "R-DME-351200", "R-RNO-379401", "R-MMU-379397", "R-MMU-189451", "R-RNO-181430", "R-HSA-8964208", "R-HSA-3214842", "R-MMU-379398", "R-HSA-379397", "R-HSA-9679191", "R-MMU-9033241", "R-MMU-9764725", "R-MMU-8964208", "R-DDI-141333", "R-BTA-141333", "R-BTA-379401", "R-BTA-379397", "R-CEL-9764725", "R-DRE-379398", "R-DDI-379397", "R-HSA-380612", "R-HSA-9033241", "R-DRE-379397"], "pathways": ["R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-3214815:r:HDACs deacetylate histones", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-351200:r:Interconversion of polyamines", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-SPO-189451:r:Heme biosynthesis", "R-DDI-189451:r:Heme 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"R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-379401:r:Dopamine clearance from the synaptic cleft", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-141334:r:PAOs oxidise polyamines to amines", "R-RNO-196807:r:Nicotinate metabolism", "R-HSA-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-BTA-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-DME-141334:r:PAOs oxidise polyamines to amines", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-379401:r:Dopamine clearance from the synaptic cleft", "R-HSA-5689603:r:UCH proteinases", "R-DDI-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DRE-380612:r:Metabolism of serotonin", "R-DDI-8964208:r:Phenylalanine metabolism", "R-BTA-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis", "R-MMU-196807:r:Nicotinate metabolism", "R-DDI-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-DDI-380612:r:Metabolism of serotonin", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-141334:r:PAOs oxidise polyamines to amines", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DDI-379401:r:Dopamine clearance from the synaptic cleft", "R-DRE-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-3214815:r:HDACs deacetylate histones", "R-HSA-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-DME-3214815:r:HDACs deacetylate histones", "R-RNO-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-RNO-379397:r:Enzymatic degradation of dopamine by COMT", "R-DRE-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-3214842:r:HDMs demethylate histones", "R-MMU-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-MMU-380612:r:Metabolism of serotonin", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5689603:r:UCH proteinases", "R-RNO-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-CEL-3214842:r:HDMs demethylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DME-351200:r:Interconversion of polyamines", "R-RNO-379401:r:Dopamine clearance from the synaptic cleft", "R-MMU-379397:r:Enzymatic degradation of dopamine by COMT", "R-MMU-189451:r:Heme biosynthesis", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-8964208:r:Phenylalanine metabolism", "R-HSA-3214842:r:HDMs demethylate histones", "R-MMU-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-HSA-379397:r:Enzymatic degradation of dopamine by COMT", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-8964208:r:Phenylalanine metabolism", "R-DDI-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-BTA-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-BTA-379401:r:Dopamine clearance from the synaptic cleft", "R-BTA-379397:r:Enzymatic degradation of dopamine by COMT", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-DDI-379397:r:Enzymatic degradation of dopamine by COMT", "R-HSA-380612:r:Metabolism of serotonin", "R-HSA-9033241:r:Peroxisomal protein import", "R-DRE-379397:r:Enzymatic degradation of dopamine by COMT"], "type": "Domain"}, "IPR002938": {"description": "FAD-binding domain", "go_ids": ["GO:0071949"], "go_terms": ["GO:0071949:FAD binding:F"], "name": "FAD-bd", "pathway_ids": ["R-HSA-71240", "R-SPO-2142789", "R-CEL-71240", "R-SCE-71240", "R-MMU-71240", "R-HSA-983231", "R-BTA-2142789", "R-DDI-71240", "R-DME-71240", "R-RNO-2142789", "R-MMU-2142789", "R-DME-2142789", "R-DRE-2142789", "R-SCE-2142789", "R-DRE-71240", "R-XTR-71240", "R-DDI-2142789", "R-HSA-2142789", "R-RNO-71240", "R-CEL-2142789"], "pathways": ["R-HSA-71240:r:Tryptophan catabolism", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-CEL-71240:r:Tryptophan catabolism", "R-SCE-71240:r:Tryptophan catabolism", "R-MMU-71240:r:Tryptophan catabolism", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-2142789:r:Ubiquinol biosynthesis", "R-DDI-71240:r:Tryptophan catabolism", "R-DME-71240:r:Tryptophan catabolism", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis", "R-DRE-2142789:r:Ubiquinol biosynthesis", 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"R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-PFA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR003010": {"description": "Carbon-nitrogen hydrolase", "go_ids": [], "go_terms": [], "name": "C-N_Hydrolase", "pathway_ids": ["R-SPO-196807", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-MMU-196807", "R-DME-196780", "R-MMU-163125", "R-DDI-73621", "R-SCE-196807", "R-SCE-6798695", "R-HSA-196780", "R-HSA-196807", "R-RNO-73621", "R-HSA-199220", "R-DDI-196807", "R-HSA-73621", "R-MMU-199220", "R-MMU-196780", "R-RNO-196807", "R-HSA-163125", "R-CFA-199220", "R-RNO-196780", "R-BTA-196807", "R-CFA-163125", "R-DRE-6798695", "R-DME-196807", "R-MMU-6798695", "R-HSA-3371598", "R-CFA-6798695", "R-MMU-73621", "R-RNO-6798695"], "pathways": ["R-SPO-196807:r:Nicotinate metabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-196807:r:Nicotinate metabolism", "R-DME-196780:r:Biotin transport and metabolism", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DDI-73621:r:Pyrimidine catabolism", "R-SCE-196807:r:Nicotinate metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-196780:r:Biotin transport and metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-RNO-73621:r:Pyrimidine catabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-HSA-73621:r:Pyrimidine catabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-196780:r:Biotin transport and metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-CFA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-BTA-196807:r:Nicotinate metabolism", "R-CFA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-196807:r:Nicotinate metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-3371598:r:Defective BTD causes biotidinase deficiency", "R-CFA-6798695:r:Neutrophil degranulation", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR003013": {"description": "Erythropoietin", "go_ids": ["GO:0005128", "GO:0005576"], "go_terms": ["GO:0005128:erythropoietin receptor binding:F", "GO:0005576:extracellular region:C"], "name": "Erythroptn", "pathway_ids": ["R-SSC-9027276", "R-HSA-1234158", "R-HSA-9006335", "R-BTA-9027276", "R-HSA-9027277", "R-MMU-9027276", "R-DRE-9027276", "R-BTA-9027284", "R-SSC-9027284", "R-HSA-9027284", "R-RNO-9027276", "R-HSA-9027283", "R-HSA-9027276", "R-RNO-9027284", "R-MMU-9027284"], "pathways": ["R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-DRE-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-9027284:r:Erythropoietin activates RAS"], "type": "Family"}, "IPR003018": {"description": "GAF domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "GAF", "pathway_ids": ["R-RNO-418555", "R-HSA-9013422", "R-HSA-445355", "R-RNO-9013422", "R-HSA-2514859", "R-CEL-418457", "R-MMU-4086398", "R-RNO-2485179", "R-HSA-2485179", "R-HSA-418555", "R-RNO-2514859", "R-CFA-445355", "R-MMU-445355", "R-DME-9013422", "R-DME-445355", "R-MMU-418457", "R-BTA-418457", "R-CEL-418555", "R-BTA-9013422", "R-CFA-418457", "R-RNO-4086398", "R-HSA-418457", "R-BTA-445355", "R-MMU-9013422", "R-RNO-445355", "R-DME-418457", "R-CFA-9013422", "R-MMU-2514859", "R-RNO-418457", "R-MMU-2485179", "R-HSA-4086398", "R-CFA-2485179", "R-CFA-4086398", "R-MMU-418555"], "pathways": ["R-RNO-418555:r:G alpha (s) signalling events", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-418457:r:cGMP effects", "R-MMU-4086398:r:Ca2+ pathway", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CFA-445355:r:Smooth Muscle Contraction", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-DME-445355:r:Smooth Muscle Contraction", "R-MMU-418457:r:cGMP effects", "R-BTA-418457:r:cGMP effects", "R-CEL-418555:r:G alpha (s) signalling events", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-418457:r:cGMP effects", "R-RNO-4086398:r:Ca2+ pathway", "R-HSA-418457:r:cGMP effects", "R-BTA-445355:r:Smooth Muscle Contraction", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-445355:r:Smooth Muscle Contraction", "R-DME-418457:r:cGMP effects", "R-CFA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-418457:r:cGMP effects", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-HSA-4086398:r:Ca2+ pathway", "R-CFA-2485179:r:Activation of the phototransduction cascade", "R-CFA-4086398:r:Ca2+ pathway", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Domain"}, "IPR003020": {"description": "Bicarbonate transporter, eukaryotic", "go_ids": ["GO:0005452", "GO:0006820", "GO:0016020"], "go_terms": ["GO:0005452:solute:inorganic anion antiporter activity:F", "GO:0006820:monoatomic anion transport:P", "GO:0016020:membrane:C"], "name": "HCO3_transpt_euk", "pathway_ids": ["R-HSA-9013405", "R-MMU-9035034", "R-HSA-9925563", "R-MMU-1237044", "R-HSA-425381", "R-BTA-425381", "R-MMU-9013407", "R-HSA-1247673", "R-RNO-1237044", "R-RNO-1247673", "R-MMU-425381", "R-DRE-425381", "R-RNO-9035034", "R-MMU-1247673", "R-RNO-9013407", "R-HSA-5619054", "R-HSA-1237044", "R-HSA-5619050", "R-MMU-9013406", "R-HSA-9035034", "R-RNO-9013406", "R-HSA-9013406", "R-HSA-9013409", "R-RNO-425381", "R-HSA-9013407"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-425381:r:Bicarbonate transporters", "R-BTA-425381:r:Bicarbonate transporters", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-MMU-425381:r:Bicarbonate transporters", "R-DRE-425381:r:Bicarbonate transporters", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-5619054:r:Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-5619050:r:Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-425381:r:Bicarbonate transporters", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR003021": {"description": "Rad1/Rec1/Rad17", "go_ids": ["GO:0000077"], "go_terms": ["GO:0000077:DNA damage checkpoint signaling:P"], "name": "Rad1_Rec1_Rad17", "pathway_ids": ["R-MMU-69473", "R-SPO-176187", "R-HSA-9709570", "R-HSA-5693607", "R-CEL-176187", "R-HSA-6804756", "R-MMU-5685938", "R-HSA-5693616", "R-HSA-69473", "R-SCE-176187", "R-MMU-176187", "R-MMU-6804756", "R-HSA-176187", "R-HSA-5685938", "R-MMU-5693607", "R-DME-176187"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-CEL-176187:r:Activation of ATR in response to replication stress", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Family"}, "IPR003029": {"description": "S1 domain", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "S1_domain", "pathway_ids": ["R-RNO-6781823", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-HSA-9833482", "R-MMU-9770562", "R-RNO-73779", "R-GGA-381042", "R-HSA-381042", "R-DDI-73776", "R-DME-72163", "R-SPO-72731", "R-RNO-72163", "R-SPO-6781823", "R-RNO-382556", "R-SPO-9930044", "R-DDI-6782210", "R-HSA-167158", "R-MMU-75955", "R-RNO-9018519", "R-HSA-72695", "R-RNO-73776", "R-MMU-112382", "R-DDI-72163", "R-BTA-9018519", "R-DRE-75955", "R-SCE-72731", "R-SPO-76042", "R-SCE-6807505", "R-SCE-429958", "R-HSA-73776", "R-BTA-77075", "R-SCE-6791226", "R-DDI-674695", "R-XTR-9840373", "R-SPO-6796648", "R-BTA-72731", "R-SCE-72702", "R-BTA-72163", "R-MMU-9930044", "R-BTA-75955", "R-MMU-6791226", "R-DRE-6782210", "R-DME-72731", "R-BTA-75953", "R-MMU-72163", "R-SPO-9018519", "R-BTA-6782135", "R-BTA-72702", "R-HSA-6803529", "R-HSA-72706", "R-HSA-167242", "R-DME-75955", "R-HSA-72702", "R-HSA-8851708", "R-RNO-72649", "R-CEL-674695", "R-HSA-167161", "R-HSA-72163", "R-GGA-72649", "R-DME-112382", "R-CEL-112382", "R-HSA-9670095", "R-HSA-167160", "R-DDI-77075", "R-DDI-72731", "R-DRE-6803529", "R-HSA-450604", "R-SPO-73779", "R-DDI-113418", "R-MMU-72086", "R-BTA-6782210", "R-DME-72702", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DDI-382556", "R-HSA-6781827", "R-HSA-5578749", "R-DME-72649", "R-RNO-9840373", "R-HSA-156827", "R-BTA-5578749", "R-XTR-72702", "R-HSA-6790901", "R-DRE-72163", "R-PFA-72731", "R-MMU-6781823", "R-BTA-6781823", "R-MMU-72731", "R-PFA-156827", "R-HSA-9836573", "R-HSA-203927", "R-DDI-73772", "R-DRE-9770562", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-MMU-73776", "R-DDI-76042", "R-CEL-72163", "R-SPO-429958", "R-HSA-167172", "R-DRE-6781823", "R-SCE-72695", "R-BTA-73779", "R-BTA-9840373", "R-MMU-72695", "R-SCE-73779", "R-RNO-113418", "R-SCE-156827", "R-MMU-382556", "R-CEL-75955", "R-HSA-72203", "R-MMU-6796648", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-RNO-6796648", "R-RNO-75955", "R-SCE-6781823", "R-RNO-72702", "R-DRE-73776", "R-BTA-674695", "R-HSA-72649", "R-MMU-156827", "R-SCE-9018519", "R-BTA-6803529", "R-DRE-6782135", "R-HSA-167290", "R-RNO-77075", "R-MMU-450513", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-HSA-450385", "R-HSA-450513", "R-RNO-9770562", "R-GGA-9840373", "R-HSA-674695", "R-HSA-76042", "R-BTA-6807505", "R-SPO-72163", "R-BTA-72203", "R-XTR-382556", "R-DDI-156827", "R-HSA-112382", "R-HSA-73779", "R-MMU-9840373", "R-DRE-72165", "R-SCE-382556", "R-MMU-72203", "R-RNO-6807505", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-RNO-674695", "R-DRE-73779", "R-BTA-76042", "R-SPO-6807505", "R-DME-6791226", "R-DRE-75953", "R-HSA-6796648", "R-MMU-381042", "R-RNO-72695", "R-HSA-6781823", "R-SCE-450385", "R-MMU-72706", "R-HSA-167287", "R-DRE-6807505", "R-HSA-167246", "R-HSA-380994", "R-DRE-6796648", "R-DRE-113418", "R-RNO-72165", "R-PFA-72702", "R-HSA-75953", "R-BTA-72695", "R-HSA-77075", "R-BTA-381042", "R-HSA-429958", "R-SPO-72086", "R-GGA-72731", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-DRE-9018519", "R-SPO-75953", "R-HSA-5601884", "R-RNO-6782210", "R-SPO-113418", "R-BTA-156827", "R-RNO-156827", "R-SPO-72706", "R-RNO-72203", "R-RNO-76042", "R-DDI-73779", "R-BTA-72086", "R-DDI-72695", "R-DME-674695", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-RNO-381042", "R-MMU-674695", "R-MMU-6807505", "R-DME-9840373", "R-SCE-76042", "R-MMU-9018519", "R-HSA-9648895", "R-SCE-9840373", "R-SPO-9770562", "R-RNO-5578749", "R-DDI-6807505", "R-HSA-167200", "R-DDI-9840373", "R-RNO-112382", "R-HSA-6791226", "R-MMU-450604", "R-SCE-674695", "R-BTA-9770562", "R-SPO-156827", "R-MMU-6782210", "R-DDI-381042", "R-BTA-72649", "R-GGA-72695", "R-RNO-75953", "R-HSA-5617472", "R-GGA-72702", "R-DDI-72702", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-PFA-72695", "R-HSA-72731", "R-SPO-72702", "R-SPO-382556", "R-MMU-450385", "R-HSA-9930044", "R-DME-156827", "R-MMU-6782135", "R-BTA-382556", "R-DME-382556", "R-BTA-113418", "R-MMU-429958", "R-HSA-72086", "R-DDI-9770562", "R-PFA-9840373", "R-DME-381042", "R-MMU-72649", "R-HSA-167162", "R-DRE-77075", "R-HSA-167152", "R-HSA-113418", "R-BTA-112382", "R-SCE-6782210", "R-HSA-9918481", "R-RNO-6803529", "R-BTA-6796648", "R-XTR-381042", "R-SPO-72203", "R-SCE-72203", "R-SCE-6796648", "R-XTR-72695", "R-HSA-9840373", "R-RNO-72086", "R-DME-72695", "R-SPO-77075", "R-MMU-72702", "R-DRE-76042", "R-SPO-72649", "R-SPO-72695", "R-SCE-113418", "R-HSA-382556", "R-SCE-72086", "R-RNO-6782135", "R-SCE-450513", "R-SPO-9840373", "R-XTR-156827", "R-HSA-6782135", "R-RNO-72731", "R-DRE-72203", "R-DRE-72086", "R-SCE-72649", "R-DRE-674695", "R-PFA-381042", "R-SCE-77075", "R-DDI-75953", "R-SPO-6782135", "R-SPO-6791226", "R-HSA-9633012"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA 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"R-SCE-72086:r:mRNA Capping", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DRE-72086:r:mRNA Capping", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-PFA-381042:r:PERK regulates gene expression", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR003032": {"description": "Ryanodine receptor Ryr", "go_ids": [], "go_terms": [], "name": "Ryanodine_rcpt", "pathway_ids": ["R-HSA-5578775", "R-MMU-5578775", "R-RNO-2672351", "R-HSA-2672351", "R-MMU-2672351", "R-RNO-5578775"], "pathways": ["R-HSA-5578775:r:Ion homeostasis", "R-MMU-5578775:r:Ion homeostasis", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-RNO-5578775:r:Ion homeostasis"], "type": "Domain"}, "IPR003033": {"description": "SCP2 sterol-binding domain", "go_ids": [], "go_terms": [], "name": "SCP2_sterol-bd_dom", "pathway_ids": ["R-MMU-2046106", "R-MMU-193368", "R-RNO-2046106", "R-HSA-193368", "R-HSA-389887", "R-MMU-9033241", "R-RNO-9033241", "R-MMU-389887", "R-RNO-389887", "R-HSA-390247", "R-MMU-390247", "R-RNO-193368", "R-HSA-9033500", "R-HSA-2046106", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR003034": {"description": "SAP domain", "go_ids": [], "go_terms": [], "name": "SAP_dom", "pathway_ids": 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"R-MMU-5663220", "R-HSA-110314", "R-SPO-3232118", "R-RNO-4615885", "R-DRE-5693607", "R-SPO-6798695", "R-HSA-9819196", "R-MMU-3232142", "R-HSA-3108214", "R-DRE-4615885", "R-RNO-8864260", "R-CEL-3899300", "R-MMU-4615885", "R-MMU-5693565", "R-DRE-3108214", "R-MMU-4085377", "R-HSA-196791", "R-HSA-877312", "R-HSA-1834949", "R-RNO-159236", "R-HSA-72165", "R-MMU-4090294", "R-HSA-4615885", "R-SCE-3232118", "R-HSA-9918481", "R-MMU-111465", "R-MMU-877312", "R-MMU-5693607", "R-HSA-72203", "R-GGA-353423", "R-MMU-3899300", "R-HSA-9770562", "R-DRE-4755510", "R-SPO-4551638", "R-HSA-4085377", "R-RNO-5250924", "R-MMU-8864260", "R-RNO-4755510", "R-DRE-3899300", "R-RNO-4551638", "R-HSA-5693571", "R-SCE-4551638", "R-MMU-72187", "R-DRE-4090294", "R-MMU-72165", "R-HSA-9733709", "R-RNO-9770562", "R-HSA-5250924", "R-HSA-111465", "R-HSA-5663220", "R-HSA-3899300", "R-MMU-4755510"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DRE-4085377:r:SUMOylation of SUMOylation proteins", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72187:r:mRNA 3'-end processing", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-164843:r:2-LTR circle formation", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-196791:r:Vitamin D (calciferol) metabolism", "R-DRE-3232118:r:SUMOylation of transcription factors", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-3232118:r:SUMOylation of transcription factors", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DRE-4755510:r:SUMOylation of immune response proteins", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-RNO-4755510:r:SUMOylation of immune response proteins", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SCE-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-72187:r:mRNA 3'-end processing", "R-DRE-4090294:r:SUMOylation of intracellular receptors", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9733709:r:Cardiogenesis", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-4755510:r:SUMOylation of immune response proteins"], "type": "Domain"}, "IPR003035": {"description": "RWP-RK domain", "go_ids": [], "go_terms": [], "name": "RWP-RK_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003036": {"description": "Core shell protein Gag P30", "go_ids": ["GO:0019068"], "go_terms": ["GO:0019068:virion assembly:P"], "name": "Gag_P30", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003038": {"description": "DAD/Ost2", "go_ids": ["GO:0016020", "GO:0008250"], "go_terms": ["GO:0016020:membrane:C", "GO:0008250:oligosaccharyltransferase complex:C"], "name": "DAD/Ost2", "pathway_ids": ["R-RNO-9931295", "R-MMU-9931295", "R-GGA-9931295", "R-SSC-9931295", "R-BTA-9931295", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9918432", "R-BTA-9768727", "R-HSA-9931295", "R-HSA-9768727", "R-MMU-9768727", "R-GGA-9768727", "R-RNO-9768727", "R-SSC-9768727"], "pathways": ["R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-GGA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-GGA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SSC-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "type": "Family"}, "IPR003051": {"description": "GPCR, family 2, corticotropin releasing factor receptor", "go_ids": ["GO:0004930", "GO:0016020"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F", "GO:0016020:membrane:C"], "name": "GPCR_2_CRF_rcpt", "pathway_ids": ["R-HSA-418555", "R-HSA-373080", "R-RNO-373080", "R-MMU-373080", "R-HSA-422085", "R-MMU-418555"], "pathways": ["R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Family"}, "IPR003059": {"description": "Colicin lysis protein", "go_ids": ["GO:0019835", "GO:0019867"], "go_terms": ["GO:0019835:cytolysis:P", "GO:0019867:outer membrane:C"], "name": "Lysis_col", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003061": {"description": "Colicin E1 (microcin) immunity protein", "go_ids": ["GO:0015643", "GO:0030153"], "go_terms": ["GO:0015643:toxic substance binding:F", "GO:0030153:bacteriocin immunity:P"], "name": "Microcin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003063": {"description": "Cloacin immunity protein family", "go_ids": ["GO:0015643", "GO:0030153"], "go_terms": ["GO:0015643:toxic substance binding:F", "GO:0030153:bacteriocin immunity:P"], "name": "Cloacn_immnty_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003064": {"description": "Norrie disease protein", "go_ids": ["GO:0005576", "GO:0016055"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0016055:Wnt signaling pathway:P"], "name": "Norrie_dis", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003065": {"description": "Surface presentation of antigens protein SpaK", "go_ids": [], "go_terms": [], "name": "Invas_SpaK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003066": {"description": "Surface presentation of antigens protein SpaN", "go_ids": [], "go_terms": [], "name": "SpaN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003084": {"description": "Class I/II Histone deacetylase HDAC", "go_ids": ["GO:0004407"], "go_terms": ["GO:0004407:histone deacetylase activity:F"], "name": "HDAC_I/II", "pathway_ids": ["R-MMU-2173795", "R-BTA-9824594", "R-HSA-9022692", "R-GGA-8936459", "R-HSA-8936459", "R-HSA-427413", "R-MMU-3214815", "R-BTA-201722", "R-CEL-9701898", "R-DRE-2467813", "R-DRE-400206", "R-RNO-9018519", "R-RNO-8936459", "R-BTA-9018519", "R-MMU-1538133", "R-RNO-9825892", "R-MMU-4551638", "R-SPO-3214815", "R-HSA-9844594", "R-RNO-983231", "R-GGA-8943724", "R-DME-9764725", "R-GGA-1538133", "R-BTA-2173795", "R-HSA-9824594", "R-HSA-2122947", "R-HSA-9701898", "R-MMU-9824594", "R-HSA-9022537", "R-HSA-983231", "R-BTA-4551638", "R-HSA-9764725", 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"R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-XTR-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-GGA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-2500257:r:Resolution of Sister 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"PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-MMU-8941858", "R-RNO-933541", "R-HSA-8936459", "R-CEL-9701898", "R-RNO-9018519", "R-HSA-9818030", "R-CEL-9617629", "R-HSA-9616222", "R-HSA-9701898", "R-HSA-9614657", "R-HSA-2122947", "R-MMU-6804760", "R-HSA-9931521", "R-HSA-6804760", "R-RNO-9759194", "R-MMU-3371568", "R-CEL-8939246", "R-MMU-350054", "R-HSA-6804114", "R-MMU-6804758", "R-HSA-9793380", "R-RNO-9841922", "R-RNO-5621575", "R-HSA-2644606", "R-HSA-9031628", "R-HSA-9768919", "R-HSA-9833109", "R-CEL-8951936", "R-HSA-8941856", "R-HSA-9705671", "R-CEL-8936459", "R-MMU-2122947", "R-HSA-9735871", "R-CEL-3899300", "R-MMU-9759194", "R-MMU-9029569", "R-HSA-3371568", "R-HSA-9818028", "R-HSA-9617629", "R-RNO-400206", "R-MMU-8951936", "R-HSA-9839394", "R-MMU-3899300", "R-RNO-9856649", "R-HSA-210744", "R-HSA-156711", "R-HSA-381340", "R-MMU-8866907", "R-MMU-9701898", "R-HSA-9707616", "R-HSA-6811555", "R-HSA-350054", "R-HSA-201722", "R-HSA-933541", "R-HSA-9909649", "R-RNO-8941856", "R-RNO-8866907", "R-CEL-9018519", "R-HSA-3214847", "R-HSA-9856649", "R-RNO-9617629", "R-HSA-2426168", "R-MMU-9707564", "R-MMU-9856649", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-1234158", "R-MMU-5689901", "R-MMU-201722", "R-MMU-8939246", "R-HSA-9818749", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-1234158", "R-RNO-350054", "R-HSA-9933387", "R-HSA-9707564", "R-CEL-9856649", "R-HSA-9018519", "R-HSA-8951936", "R-RNO-3134973", "R-MMU-8936459", "R-MMU-5250924", "R-MMU-5621575", "R-HSA-8941858", "R-MMU-3134973", "R-CEL-9759194", "R-MMU-9018519", "R-HSA-9013695", "R-HSA-8939243", "R-HSA-9818026", "R-HSA-400206", "R-HSA-3134973", "R-MMU-400206", "R-HSA-5617472", "R-HSA-9818027", "R-HSA-5689901", "R-HSA-9819196", "R-MMU-933541", "R-RNO-201722", "R-HSA-9818035", "R-CEL-201722", "R-MMU-9617629", "R-RNO-8939246", "R-HSA-1912408", "R-HSA-6804758", "R-RNO-3371568", "R-HSA-918233", "R-HSA-5621575", "R-HSA-9759194", "R-HSA-9029569", "R-HSA-2173796", "R-HSA-9931509", "R-CEL-1234158", "R-HSA-8866907", "R-HSA-9013508", "R-HSA-2894862", "R-RNO-9707564", "R-MMU-8939243", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-6803204", "R-HSA-9818032", "R-MMU-8941856", "R-HSA-5250924", "R-MMU-6811555", "R-RNO-1234158", "R-HSA-3899300", "R-HSA-2197563", "R-HSA-8939246", "R-CEL-8939243"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-CEL-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-3371568:r:Attenuation phase", "R-CEL-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-3371568:r:Attenuation phase", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-9839394:r:TGFBR3 expression", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9707616:r:Heme signaling", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-3371568:r:Attenuation phase", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR003102": {"description": "Cyclic AMP-responsive element-binding protein 1-like, pKID", "go_ids": ["GO:0005515", "GO:0006355"], "go_terms": ["GO:0005515:protein binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "CREB1-like_pKID", "pathway_ids": ["R-RNO-9031628", "R-HSA-9022702", "R-CEL-375165", "R-CEL-9634638", "R-RNO-198693", "R-HSA-2151201", "R-DME-9634638", "R-HSA-9022692", "R-CEL-442742", "R-DME-199920", "R-DME-375165", "R-RNO-442742", "R-HSA-198693", "R-MMU-199920", "R-MMU-881907", "R-HSA-881907", "R-RNO-199920", "R-HSA-375165", "R-DME-198693", "R-HSA-442742", "R-HSA-442720", "R-MMU-198693", "R-RNO-375165", "R-HSA-111932", "R-HSA-9616222", "R-HSA-9660821", "R-HSA-9931509", "R-HSA-9022707", "R-HSA-442729", "R-CEL-881907", "R-CEL-198693", "R-BTA-199920", "R-HSA-111931", "R-HSA-5674400", "R-MMU-442742", "R-CEL-199920", "R-HSA-9707616", "R-HSA-199920", "R-HSA-9609690", "R-HSA-9634638", "R-MMU-9031628", "R-HSA-9824585", "R-DME-881907", "R-HSA-9931510", "R-RNO-881907", "R-HSA-9022699", "R-HSA-9856649", "R-MMU-9634638", "R-HSA-2197563", "R-HSA-9031628", "R-CEL-9031628", "R-DME-442742", "R-HSA-9664323", "R-RNO-9634638", "R-MMU-375165"], "pathways": ["R-RNO-9031628:r:NGF-stimulated transcription", "R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-CEL-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-CEL-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-DME-199920:r:CREB phosphorylation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-RNO-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-MMU-199920:r:CREB phosphorylation", "R-MMU-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-199920:r:CREB phosphorylation", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-DME-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-198693:r:AKT phosphorylates targets in the nucleus", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-9022707:r:MECP2 regulates transcription factors", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-CEL-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-BTA-199920:r:CREB phosphorylation", "R-HSA-111931:r:PKA-mediated phosphorylation of CREB", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-CEL-199920:r:CREB phosphorylation", "R-HSA-9707616:r:Heme signaling", "R-HSA-199920:r:CREB phosphorylation", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9031628:r:NGF-stimulated transcription", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-DME-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-RNO-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-DME-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-375165:r:NCAM signaling for neurite out-growth"], "type": "Domain"}, "IPR003103": {"description": "BAG domain", "go_ids": ["GO:0051087"], "go_terms": ["GO:0051087:protein-folding chaperone binding:F"], "name": "BAG_domain", "pathway_ids": ["R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-BTA-3371453", "R-HSA-9918487", "R-MMU-75893", "R-HSA-75893", "R-HSA-5655302", "R-CEL-3371453", "R-HSA-8853336", "R-MMU-3371453"], "pathways": ["R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MMU-75893:r:TNF signaling", "R-HSA-75893:r:TNF signaling", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR003105": {"description": "SRA-YDG", "go_ids": [], "go_terms": [], "name": "SRA_YDG", "pathway_ids": ["R-HSA-5334118", "R-MMU-3899300", "R-HSA-9821002", "R-HSA-3899300"], "pathways": ["R-HSA-5334118:r:DNA methylation", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-3899300:r:SUMOylation of transcription cofactors"], "type": "Domain"}, "IPR003106": {"description": "Leucine zipper, homeobox-associated", "go_ids": ["GO:0043565", "GO:0006355"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Leu_zip_homeo", "pathway_ids": ["R-HSA-6807878", "R-HSA-9703465", "R-HSA-432722"], "pathways": ["R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR003107": {"description": "HAT (Half-A-TPR) repeat", "go_ids": ["GO:0006396"], "go_terms": ["GO:0006396:RNA processing:P"], "name": "HAT", "pathway_ids": ["R-DDI-6782135", "R-RNO-6781823", "R-HSA-9930044", "R-HSA-6781827", "R-MMU-6782135", "R-DME-77595", "R-DME-6781823", "R-MMU-9770562", "R-DDI-6791226", "R-MMU-77595", "R-DME-6791226", "R-HSA-73856", "R-DME-72163", "R-RNO-72163", "R-DDI-6782210", "R-HSA-72187", "R-DDI-72163", "R-HSA-6790901", "R-HSA-6781823", "R-DME-9770562", "R-HSA-77595", "R-DRE-72163", "R-MMU-6781823", "R-SCE-6791226", "R-RNO-72165", "R-HSA-6782210", "R-HSA-72165", "R-DME-73856", "R-SCE-6782210", "R-DME-6782135", "R-HSA-9918481", "R-SPO-72203", "R-RNO-6782210", "R-BTA-72163", "R-MMU-6791226", "R-HSA-9770562", "R-BTA-72165", "R-MMU-72163", "R-RNO-6782135", "R-DDI-6781823", "R-MMU-73856", "R-HSA-6782135", "R-SPO-9770562", "R-HSA-72163", "R-MMU-72187", "R-MMU-72165", "R-HSA-6791226", "R-SPO-6782210", "R-DME-6782210", "R-MMU-6782210", "R-SPO-6782135", "R-SPO-72163", "R-SPO-6791226", "R-SCE-6782135"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-9770562:r:mRNA Polyadenylation", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72187:r:mRNA 3'-end processing", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Repeat"}, "IPR003108": {"description": "GAR domain", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "GAR_dom", "pathway_ids": ["R-HSA-9013420", "R-HSA-2022090", "R-MMU-9013420", "R-MMU-446107", "R-HSA-9696270", "R-MMU-264870", "R-MMU-9013424", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-264870", "R-HSA-9013424", "R-HSA-446107", "R-MMU-9696273", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-9013420:r:RHOU GTPase cycle", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR003109": {"description": "GoLoco motif", "go_ids": ["GO:0030695"], "go_terms": ["GO:0030695:GTPase regulator activity:F"], "name": "GoLoco_motif", "pathway_ids": ["R-HSA-418594", "R-HSA-8853659", "R-HSA-392517", "R-MMU-392517", "R-MMU-8853659", "R-DME-418594", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-8853659:r:RET signaling", "R-HSA-392517:r:Rap1 signalling", "R-MMU-392517:r:Rap1 signalling", "R-MMU-8853659:r:RET signaling", "R-DME-418594:r:G alpha (i) signalling events", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Conserved_site"}, "IPR003110": {"description": "Phosphorylated immunoreceptor signalling ITAM", "go_ids": ["GO:0004888", "GO:0007166", "GO:0016020"], "go_terms": ["GO:0004888:transmembrane signaling receptor activity:F", "GO:0007166:cell surface receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "Phos_immunorcpt_sig_ITAM", "pathway_ids": ["R-HSA-6798695", "R-MMU-8856828", "R-CFA-202430", "R-CFA-202433", "R-MMU-114604", "R-HSA-8856828", "R-RNO-5621480", "R-CFA-202427", "R-HSA-2871796", "R-BTA-202424", "R-RNO-202433", "R-BTA-6798695", "R-HSA-2029481", "R-CFA-198933", "R-RNO-2871809", "R-MMU-202430", "R-MMU-2871796", "R-BTA-75892", "R-HSA-202427", "R-RNO-2029485", "R-RNO-202427", "R-BTA-2871809", "R-SSC-202433", "R-RNO-202424", "R-HSA-164944", "R-MMU-2029485", "R-HSA-202430", "R-HSA-5621480", "R-HSA-114604", "R-BTA-198933", "R-HSA-983695", "R-RNO-198933", "R-RNO-2029481", "R-CFA-983695", "R-HSA-2029482", "R-SSC-2029485", "R-MMU-5690714", "R-CFA-389948", "R-BTA-5690714", "R-HSA-75892", "R-BTA-389948", "R-MMU-198933", "R-MMU-2871837", "R-RNO-2730905", "R-SSC-389948", "R-BTA-114604", "R-HSA-198933", "R-MMU-202427", "R-MMU-6798695", "R-MMU-2730905", "R-BTA-202433", "R-HSA-9664323", "R-RNO-6798695", "R-RNO-2871796", "R-SSC-202427", "R-MMU-8856825", "R-HSA-202433", "R-BTA-202427", "R-SSC-198933", "R-HSA-2029485", "R-CFA-5690714", "R-RNO-75892", "R-RNO-2029482", "R-HSA-2454202", "R-HSA-2871837", "R-BTA-2871837", "R-MMU-75892", "R-BTA-2871796", "R-BTA-2454202", "R-RNO-8856828", "R-HSA-2730905", "R-SSC-2029482", "R-SSC-8856825", "R-MMU-5621480", "R-MMU-202424", "R-CFA-202424", "R-SSC-2029481", "R-BTA-8856828", "R-MMU-389948", "R-MMU-202433", "R-BTA-202430", "R-RNO-8856825", "R-HSA-2871809", "R-HSA-9679191", "R-MMU-983695", "R-HSA-5690714", "R-MMU-2454202", "R-MMU-2029482", "R-MMU-2029481", "R-SSC-202424", "R-RNO-114604", "R-BTA-8856825", "R-BTA-2730905", "R-RNO-2454202", "R-SSC-202430", "R-SSC-8856828", "R-HSA-202424", "R-HSA-8856825", "R-MMU-2871809", "R-BTA-983695", "R-BTA-5621480", "R-RNO-389948", "R-RNO-202430", "R-HSA-9664422", "R-HSA-389948", "R-HSA-202733", "R-RNO-2871837"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CFA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-CFA-202433:r:Generation of second messenger molecules", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-5621480:r:Dectin-2 family", "R-CFA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-BTA-202424:r:Downstream TCR signaling", "R-RNO-202433:r:Generation of second messenger molecules", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2029481:r:FCGR activation", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-SSC-202433:r:Generation of second messenger molecules", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-164944:r:Nef and signal transduction", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-2029481:r:FCGR activation", "R-CFA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SSC-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-CFA-389948:r:Co-inhibition by PD-1", "R-BTA-5690714:r:CD22 mediated BCR regulation", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-BTA-389948:r:Co-inhibition by PD-1", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-SSC-389948:r:Co-inhibition by PD-1", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-BTA-202433:r:Generation of second messenger molecules", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-SSC-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-202433:r:Generation of second messenger molecules", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-CFA-5690714:r:CD22 mediated BCR regulation", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-BTA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5621480:r:Dectin-2 family", "R-MMU-202424:r:Downstream TCR signaling", "R-CFA-202424:r:Downstream TCR signaling", "R-SSC-2029481:r:FCGR activation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-202433:r:Generation of second messenger molecules", "R-BTA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029481:r:FCGR activation", "R-SSC-202424:r:Downstream TCR signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-SSC-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-5621480:r:Dectin-2 family", "R-RNO-389948:r:Co-inhibition by PD-1", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Repeat"}, "IPR003111": {"description": "Lon protease, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Lon_prtase_N", "pathway_ids": ["R-BTA-9033241", "R-DDI-9837999", "R-RNO-9033241", "R-MMU-9837999", "R-CEL-9837999", "R-HSA-390471", "R-SPO-9837999", "R-SCE-9837999", "R-MMU-983168", "R-SPO-983168", "R-HSA-9841251", "R-DME-9837999", "R-HSA-9837999", "R-HSA-9679191", "R-HSA-983168", "R-RNO-9837999", "R-MMU-9033241", "R-HSA-9033241"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR003112": {"description": "Olfactomedin-like domain", "go_ids": [], "go_terms": [], "name": "Olfac-like_dom", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR003113": {"description": "Phosphatidylinositol 3-kinase, adaptor-binding domain", "go_ids": [], "go_terms": [], "name": "PI3K_ABD", "pathway_ids": ["PWY-6352", "R-HSA-9842640", "R-MMU-1250342", "R-HSA-9607240", "R-DDI-114604", "R-BTA-198203", "R-MMU-6811558", "R-MMU-114604", "R-MMU-5654720", "R-BTA-5673001", "R-HSA-912631", "R-BTA-8851907", "R-RNO-9607240", "R-RNO-9009391", "R-MMU-210993", "R-MMU-9009391", "R-RNO-512988", "R-BTA-1963642", "R-BTA-5654710", "R-RNO-912631", "R-HSA-5654695", "R-MMU-201556", "R-CEL-5654695", "R-BTA-4420097", "R-RNO-6811558", "R-HSA-8853659", "R-CEL-1257604", "R-BTA-6811558", "R-HSA-9603381", "R-RNO-1963642", "R-HSA-512988", "R-RNO-416476", "R-MMU-5673001", "R-MMU-186763", "R-HSA-114604", "R-RNO-210993", "R-HSA-983695", "R-HSA-5654689", "R-HSA-2424491", "R-HSA-5637810", "R-DDI-392451", "R-MMU-912526", "R-CEL-1433557", "R-RNO-2730905", "R-MMU-1963642", "R-HSA-389357", "R-MMU-2730905", "R-DDI-1660514", "R-CEL-6811558", "R-BTA-5654689", "R-BTA-2424491", "R-HSA-9680350", "R-RNO-8851907", "R-HSA-1839117", "R-BTA-1660499", "R-HSA-5655253", "R-RNO-9842663", "R-RNO-1257604", "R-HSA-2029485", "R-CEL-5654720", "R-HSA-9665348", "R-BTA-5654695", "R-BTA-9927354", "R-HSA-8851907", "R-BTA-912526", "R-HSA-9028335", "R-HSA-1963642", "R-MMU-512988", "R-HSA-2730905", "R-HSA-112399", "R-HSA-9027276", "R-BTA-1433557", "R-BTA-512988", "R-MMU-202424", "R-HSA-5655291", "R-MMU-912631", "R-BTA-180292", "R-MMU-109704", "R-HSA-5655332", "R-RNO-1250342", "R-HSA-109704", "R-MMU-1257604", "R-HSA-9842663", "R-BTA-9009391", "R-RNO-5654689", "R-MMU-1660499", "R-HSA-9009391", "R-CEL-5654689", "R-RNO-5654695", "R-RNO-1660499", "R-BTA-109704", "R-HSA-912526", "R-BTA-9013404", "R-HSA-201556", "R-BTA-1257604", "R-MMU-8851907", "R-BTA-9027276", "R-BTA-210993", "R-CEL-9009391", "R-HSA-9856530", "R-BTA-9607240", "R-MMU-5654689", "R-MMU-9013149", "R-CEL-114604", "R-HSA-9725370", "R-CEL-1250342", "R-BTA-389357", "R-MMU-416476", "R-CEL-210993", "R-MMU-9607240", "R-HSA-180292", "R-BTA-202424", "R-RNO-5654710", "R-CEL-912631", "R-RNO-9013149", "R-MMU-4420097", "R-HSA-9670439", "R-RNO-9027276", "R-MMU-9013404", "R-CEL-5673001", "R-RNO-912526", "R-HSA-4420097", "R-RNO-112399", "R-RNO-198203", "R-MMU-389357", "R-RNO-2029485", "R-MMU-5654695", "R-MMU-392451", "R-BTA-8853659", "R-RNO-202424", "R-BTA-112399", "R-RNO-9013404", "R-HSA-9673767", "R-MMU-2029485", "R-DDI-1660517", "R-HSA-9664565", "R-RNO-5673001", "R-HSA-5655302", "R-RNO-9927354", "R-RNO-389357", "R-RNO-201556", "R-HSA-9927354", "R-HSA-373753", "R-MMU-1433557", "R-CEL-201556", "R-MMU-180292", "R-HSA-210993", "R-RNO-8853659", "R-CEL-180292", "R-MMU-8853659", "R-HSA-2219530", "R-BTA-912631", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-BTA-416476", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-9703648", "R-HSA-5654720", "R-BTA-114604", "R-MMU-9027276", "R-CEL-186763", "R-HSA-1257604", "R-HSA-198203", "R-MMU-5654710", "R-RNO-4420097", "R-CEL-392451", "R-DDI-1660499", "R-BTA-5654720", "R-RNO-109704", "R-HSA-416476", "R-HSA-1250342", "R-HSA-1660499", "R-CEL-416476", "R-CEL-9013149", "R-MMU-9842663", "R-BTA-186763", "R-MMU-198203", "R-HSA-9673770", "R-BTA-201556", "R-HSA-1236382", "R-CEL-5654710", "R-BTA-2029485", "R-DDI-1660516", "R-BTA-1250342", "R-MMU-983695", "R-RNO-180292", "R-HSA-1433557", "R-MMU-112399", "R-HSA-186763", "R-RNO-114604", "R-HSA-9703465", "R-BTA-2730905", "R-RNO-2424491", "R-CEL-4420097", "R-MMU-9927354", "R-CEL-1963642", "R-HSA-5654710", "R-RNO-5654720", "R-MMU-2424491", "R-CEL-1660499", "R-HSA-202424", "R-RNO-186763", "R-HSA-392451"], "pathways": ["PWY-6352:t:3-phosphoinositide biosynthesis", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-BTA-198203:r:PI3K/AKT activation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-912631:r:Regulation of signaling by CBL", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-9607240:r:FLT3 Signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-210993:r:Tie2 Signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-912631:r:Regulation of signaling by CBL", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-201556:r:Signaling by ALK", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-BTA-2424491:r:DAP12 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-RNO-9842663:r:Signaling by LTK", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-112399:r:IRS-mediated signalling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-912631:r:Regulation of signaling by CBL", "R-BTA-180292:r:GAB1 signalosome", "R-MMU-109704:r:PI3K Cascade", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-109704:r:PI3K Cascade", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-201556:r:Signaling by ALK", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-210993:r:Tie2 Signaling", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9607240:r:FLT3 Signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-CEL-1250342:r:PI3K events in ERBB4 signaling", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-416476:r:G alpha (q) signalling events", "R-CEL-210993:r:Tie2 Signaling", "R-MMU-9607240:r:FLT3 Signaling", "R-HSA-180292:r:GAB1 signalosome", "R-BTA-202424:r:Downstream TCR signaling", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-CEL-912631:r:Regulation of signaling by CBL", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-112399:r:IRS-mediated signalling", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-8853659:r:RET signaling", "R-RNO-202424:r:Downstream TCR signaling", "R-BTA-112399:r:IRS-mediated signalling", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-201556:r:Signaling by ALK", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-373753:r:Nephrin family interactions", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-CEL-201556:r:Signaling by ALK", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-8853659:r:RET signaling", "R-CEL-180292:r:GAB1 signalosome", "R-MMU-8853659:r:RET signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-BTA-912631:r:Regulation of signaling by CBL", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-186763:r:Downstream signal transduction", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-198203:r:PI3K/AKT activation", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-109704:r:PI3K Cascade", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-416476:r:G alpha (q) signalling events", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-9842663:r:Signaling by LTK", "R-BTA-186763:r:Downstream signal transduction", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-BTA-201556:r:Signaling by ALK", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-112399:r:IRS-mediated signalling", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-2424491:r:DAP12 signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma"], "type": "Domain"}, 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"R-HSA-5674135", "R-SSC-5675221", "R-HSA-6802952", "R-MMU-3928665", "R-DME-5621575", "R-HSA-430116", "R-CEL-5673000", "R-HSA-9732724", "R-CEL-5621575", "R-MMU-9013404", "R-MMU-1295596", "R-HSA-3928662", "R-DDI-6804757", "R-GGA-5675221", "R-HSA-5673000", "R-RNO-392517", "R-DME-9013148", "R-HSA-9649948", "R-MMU-9732724", "R-DDI-5218920", "R-DME-3928665", "R-DME-1295596", "R-HSA-6802955", "R-DME-5673000", "R-HSA-170984", "R-RNO-5673000", "R-DME-5674135", "R-DME-9013149", "R-HSA-6802948", "R-MMU-170968", "R-DME-8980692", "R-RNO-9732724", "R-MMU-5621575", "R-MMU-392517", "R-MMU-5673000", "R-DME-3928662", "R-HSA-416482", "R-RNO-5675221", "R-CEL-5674135", "R-GGA-5621575", "R-DME-5675221", "R-GGA-5674135", "R-HSA-9013404", "R-MMU-9013423", "R-GGA-430116", "R-HSA-9013149", "R-HSA-8980692", "R-DDI-9856530", "R-HSA-1295596", "R-CEL-5674499", "R-DME-193648", "R-DME-416482", "R-MMU-193648", "R-HSA-5674499", "R-HSA-9726840", "R-RNO-5621575", "R-CEL-170968", "R-DME-5674499", "R-GGA-5673000", "R-HSA-392517", "R-MMU-5675221", "R-HSA-9656223", "R-RNO-430116", "R-MMU-5674135", "R-DME-432553", "R-MMU-430116", "R-MMU-8980692", "R-HSA-2672351", "R-MMU-9013148", "R-DME-430116", "R-MMU-418594", "R-RNO-418594", "R-DME-209214", "R-HSA-9013423", "R-RNO-2672351", "R-DME-392517", "R-MMU-2672351", "R-HSA-6802946", "R-HSA-5621575", "R-SSC-5674135", "R-HSA-9013148", "R-RNO-5674135", "R-RNO-5674499", "R-HSA-9032845", "R-MMU-5674499", "R-DME-209190", "R-DME-170968", "R-HSA-193648", "R-CEL-5675221", "R-CEL-392517", "R-DDI-1257604", "R-GGA-392517", "R-DME-418594", "R-CEL-430116", "R-HSA-9726842", "R-CEL-2672351", "R-HSA-418594", "R-GGA-5674499", "R-GGA-2672351", "R-HSA-187706", "R-HSA-3928665", "R-MMU-416482", "R-HSA-170968", "R-MMU-3928662", "R-DDI-389357", "R-MMU-9013149", "R-DME-9013423", "R-HSA-5675221"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-GGA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-CEL-5673000:r:RAF activation", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5673000:r:RAF activation", "R-RNO-392517:r:Rap1 signalling", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DME-5673000:r:RAF activation", "R-HSA-170984:r:ARMS-mediated activation", "R-RNO-5673000:r:RAF activation", "R-DME-5674135:r:MAP2K and MAPK activation", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-170968:r:Frs2-mediated activation", "R-DME-8980692:r:RHOA GTPase cycle", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-392517:r:Rap1 signalling", "R-MMU-5673000:r:RAF activation", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-HSA-9013404:r:RAC2 GTPase cycle", 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mutants", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-DME-430116:r:GP1b-IX-V activation signalling", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-2672351:r:Stimuli-sensing channels", "R-DME-392517:r:Rap1 signalling", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-RNO-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-MMU-5674499:r:Negative feedback regulation of MAPK pathway", "R-DME-209190:r:Phosphorylation of CI", "R-DME-170968:r:Frs2-mediated activation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-CEL-392517:r:Rap1 signalling", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-GGA-392517:r:Rap1 signalling", "R-DME-418594:r:G alpha (i) signalling events", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-418594:r:G alpha (i) signalling events", "R-GGA-5674499:r:Negative feedback regulation of MAPK pathway", "R-GGA-2672351:r:Stimuli-sensing channels", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-170968:r:Frs2-mediated activation", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR003117": {"description": "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain", "go_ids": [], "go_terms": [], "name": "cAMP_dep_PK_reg_su_I/II_a/b", "pathway_ids": ["R-SCE-164378", "R-RNO-5610787", "R-HSA-9010642", "R-MMU-380320", "R-RNO-9634597", "R-DRE-5610787", "R-HSA-432040", "R-RNO-983231", "R-HSA-442720", "R-MMU-5610787", "R-RNO-380284", "R-DME-5610787", "R-DME-164378", "R-MMU-5620912", "R-BTA-9634597", "R-RNO-164378", "R-DME-432040", "R-MMU-380259", "R-SPO-432040", "R-MMU-9634597", "R-HSA-983231", "R-MMU-380270", "R-SPO-5610787", "R-RNO-180024", "R-MMU-432040", "R-DRE-163615", "R-GGA-983231", "R-BTA-432040", "R-DME-442720", "R-CEL-180024", "R-HSA-164378", "R-BTA-164378", "R-SCE-983231", 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"R-HSA-2565942", "R-HSA-5610787", "R-MMU-180024", "R-DME-163615", "R-GGA-9856530", "R-DME-983231", "R-SCE-9634597", "R-DRE-9856530", "R-HSA-5620912", "R-HSA-9660821", "R-HSA-180024", "R-SPO-9856530", "R-GGA-180024", "R-RNO-442720", "R-RNO-8854518", "R-GGA-5610787", "R-SCE-432040", "R-DME-180024", "R-BTA-180024", "R-DRE-442720", "R-BTA-5610787", "R-HSA-380259", "R-HSA-163615"], "pathways": ["R-SCE-164378:r:PKA activation in glucagon signalling", "R-RNO-5610787:r:Hedgehog 'off' state", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-9634597:r:GPER1 signaling", "R-DRE-5610787:r:Hedgehog 'off' state", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins 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activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-163615:r:PKA activation", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-SCE-180024:r:DARPP-32 events", "R-DME-9634597:r:GPER1 signaling", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DRE-9634597:r:GPER1 signaling", "R-SCE-5610787:r:Hedgehog 'off' state", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-163615:r:PKA activation", "R-DRE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-SCE-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-SPO-9634597:r:GPER1 signaling", "R-SPO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-163615:r:PKA activation", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-DRE-180024:r:DARPP-32 events", "R-CEL-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-SPO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-SPO-163615:r:PKA activation", "R-GGA-163615:r:PKA activation", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-180024:r:DARPP-32 events", "R-DME-163615:r:PKA activation", "R-GGA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-9634597:r:GPER1 signaling", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-HSA-180024:r:DARPP-32 events", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-GGA-180024:r:DARPP-32 events", "R-RNO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-GGA-5610787:r:Hedgehog 'off' state", "R-SCE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-180024:r:DARPP-32 events", "R-BTA-180024:r:DARPP-32 events", "R-DRE-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-163615:r:PKA activation"], "type": "Domain"}, "IPR003118": {"description": "Pointed domain", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "Pointed_dom", "pathway_ids": ["R-HSA-9703465", "R-DME-2151201", "R-GGA-2559585", "R-HSA-2151201", "R-HSA-9927426", "R-MMU-2151201", "R-MMU-1912408", "R-BTA-2559585", "R-HSA-2559585", "R-HSA-9616222", "R-HSA-9927418", "R-HSA-9673768", "R-DME-2559585", "R-MMU-2559585", "R-RNO-1912408", "R-RNO-2559585", "R-HSA-1912408"], "pathways": ["R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-GGA-2559585:r:Oncogene Induced Senescence", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-MMU-1912408:r:Pre-NOTCH Transcription and Translation", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-DME-2559585:r:Oncogene Induced Senescence", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-RNO-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation"], "type": "Domain"}, "IPR003119": {"description": "Saposin A-type domain", "go_ids": [], "go_terms": [], "name": "SAP_A", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-RNO-9840310", "R-HSA-5688031", "R-MMU-9840310", "R-HSA-375276", "R-HSA-9840310", "R-RNO-5683826", "R-MMU-375276", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-HSA-418594", "R-DRE-2132295", "R-HSA-5688890", "R-HSA-5683826", "R-RNO-375276", "R-MMU-6798695", "R-BTA-5683826", "R-MMU-5683826", "R-HSA-5688849", "R-MMU-114608"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-5688031:r:Defective pro-SFTPB causes SMDP1 and RDS", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-HSA-418594:r:G alpha (i) signalling events", "R-DRE-2132295:r:MHC class II antigen presentation", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-5683826:r:Surfactant metabolism", "R-MMU-5683826:r:Surfactant metabolism", 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nBAF)", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-DRE-9766229:r:Degradation of CDH1", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-9766229:r:Degradation of CDH1", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-SPO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-CEL-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DDI-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-DDI-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-CFA-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-RNO-69541:r:Stabilization of p53", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-CFA-5689880:r:Ub-specific processing proteases", "R-DME-3214858:r:RMTs methylate histone arginines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-CFA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-RNO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-RNO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-CFA-9766229:r:Degradation of CDH1", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-BTA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9707616:r:Heme signaling", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-69541:r:Stabilization of p53", "R-SPO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-CEL-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR003122": {"description": "Chemotaxis methyl-accepting receptor Tar-related, ligand-binding", "go_ids": ["GO:0007165", "GO:0006935"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0006935:chemotaxis:P"], "name": "Tar_rcpt_lig-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003123": {"description": "VPS9 domain", "go_ids": [], "go_terms": [], "name": "VPS9", "pathway_ids": ["R-BTA-8856828", "R-MMU-8856828", "R-CEL-8856828", "R-DME-9013149", "R-HSA-8854214", "R-DME-8876198", "R-HSA-8856828", "R-RNO-8876198", "R-RNO-9013149", "R-HSA-8876198", "R-SCE-8876198", "R-HSA-9013149", "R-MMU-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-DME-8856828", "R-BTA-8876198", "R-MMU-9013149", "R-SPO-8876198"], "pathways": ["R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-8854214:r:TBC/RABGAPs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR003124": {"description": "WH2 domain", "go_ids": ["GO:0003779"], "go_terms": ["GO:0003779:actin binding:F"], "name": "WH2_dom", "pathway_ids": ["R-BTA-2029482", "R-HSA-5663213", "R-HSA-9013409", "R-HSA-9013405", "R-BTA-9013424", "R-HSA-202433", "R-HSA-8856828", "R-BTA-373753", "R-BTA-3928662", "R-RNO-9013149", "R-DDI-446353", "R-BTA-9013406", "R-HSA-9013424", "R-HSA-418885", "R-MMU-9013404", "R-MMU-4420097", "R-MMU-445355", "R-HSA-3928662", "R-DDI-9013149", "R-BTA-9013423", "R-RNO-2029482", "R-HSA-4420097", "R-HSA-9013423", "R-RNO-5663213", "R-MMU-5663213", "R-BTA-5663213", "R-RNO-445355", "R-HSA-9662360", "R-HSA-9013148", "R-DDI-9013423", "R-HSA-203641", "R-HSA-373753", "R-DDI-2029482", "R-BTA-8856828", "R-MMU-6804760", "R-HSA-445355", "R-DDI-5658442", "R-HSA-9662361", "R-DDI-5663213", "R-HSA-2029482", "R-HSA-6804760", "R-BTA-418885", "R-MMU-2029482", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-BTA-9013404", "R-MMU-9013149", "R-BTA-203641", "R-DDI-9013404", "R-HSA-9013406", "R-HSA-9664422", "R-RNO-4420097"], "pathways": ["R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-BTA-9013424:r:RHOV GTPase cycle", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-373753:r:Nephrin family interactions", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DDI-446353:r:Cell-extracellular matrix interactions", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-445355:r:Smooth Muscle Contraction", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-373753:r:Nephrin family interactions", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-BTA-418885:r:DCC mediated attractive signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-203641:r:NOSTRIN mediated eNOS trafficking", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR003125": {"description": "Domain of unknown function WSN", "go_ids": [], "go_terms": [], "name": "WSN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003126": {"description": "Zinc finger, UBR-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_UBR", "pathway_ids": ["PWY-7511", "R-DDI-6798695", "R-HSA-6798695", "R-DME-983168", "R-HSA-9920588", "R-HSA-8951664", "R-DME-6798695", "R-CEL-6798695", "R-HSA-983168", "R-CEL-983168", "R-MMU-8951664", "R-DDI-983168", "R-RNO-8951664", "R-MMU-983168", "R-SPO-983168", "R-MMU-6798695", "R-SCE-983168", "R-RNO-983168", "R-RNO-6798695", "R-CEL-8951664"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-8951664:r:Neddylation", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR003127": {"description": "SoHo domain", "go_ids": [], "go_terms": [], "name": "SoHo_dom", "pathway_ids": ["R-MMU-445355", "R-HSA-445355", "R-CEL-445355"], "pathways": ["R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-CEL-445355:r:Smooth Muscle Contraction"], "type": "Domain"}, "IPR003128": {"description": "Villin headpiece", "go_ids": ["GO:0003779", "GO:0007010"], "go_terms": ["GO:0003779:actin binding:F", "GO:0007010:cytoskeleton organization:P"], "name": "Villin_headpiece", "pathway_ids": ["R-DDI-6798695", "R-DME-6798695", "R-HSA-418885", "R-DME-264870", "R-HSA-5223345", "R-DDI-114608", "R-MMU-5223345", "R-BTA-5223345"], 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"R-BTA-196025:r:Formation of annular gap junctions", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-190873:r:Gap junction degradation", "R-BTA-75153:r:Apoptotic execution phase", "R-RNO-196025:r:Formation of annular gap junctions", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-169911:r:Regulation of Apoptosis", "R-MMU-196025:r:Formation of annular gap junctions", "R-DME-437239:r:Recycling pathway of L1", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-196025:r:Formation of annular gap junctions", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CFA-1169408:r:ISG15 antiviral mechanism", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-9031628:r:NGF-stimulated transcription", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SCE-169911:r:Regulation of Apoptosis", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-190873:r:Gap junction degradation", "R-CEL-437239:r:Recycling pathway of L1", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-RNO-75153:r:Apoptotic execution phase", "R-MMU-190873:r:Gap junction degradation", "R-RNO-190873:r:Gap junction degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-75153:r:Apoptotic execution phase", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-DRE-75153:r:Apoptotic execution phase", "R-HSA-196025:r:Formation of annular gap junctions"], "type": "Domain"}, "IPR003131": {"description": "Potassium channel tetramerisation-type BTB domain", "go_ids": ["GO:0051260"], "go_terms": ["GO:0051260:protein homooligomerization:P"], "name": "T1-type_BTB", "pathway_ids": ["R-BTA-983168", "R-HSA-5576890", "R-BTA-8951664", "R-DME-1296072", "R-MMU-5576890", "R-BTA-1296072", "R-RNO-5576894", "R-CEL-5576890", "R-HSA-8866904", "R-RNO-9696270", "R-HSA-8951664", "R-DRE-8951664", "R-DME-8866904", "R-DME-5576894", "R-CEL-983168", "R-MMU-381676", "R-DRE-983168", "R-MMU-8951664", "R-DRE-9696264", "R-RNO-8866904", "R-HSA-9013148", "R-XTR-9696264", "R-RNO-983168", "R-GGA-9696270", "R-DME-381676", "R-DRE-9696270", "R-HSA-9018519", "R-MMU-1296072", "R-GGA-9696264", "R-MMU-5576894", "R-HSA-8931987", "R-HSA-9696270", "R-BTA-5576894", "R-HSA-983168", "R-RNO-1296072", "R-RNO-381676", "R-GGA-381676", "R-CEL-381676", "R-DME-5576890", "R-HSA-9696264", "R-GGA-1296072", "R-HSA-381676", "R-RNO-8951664", "R-RNO-9696264", "R-HSA-1296072", "R-MMU-8866904", "R-MMU-983168", "R-MMU-9696264", "R-HSA-5576894", "R-MMU-9696270", "R-CEL-8951664", "R-RNO-5576890"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-BTA-8951664:r:Neddylation", "R-DME-1296072:r:Voltage gated Potassium channels", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-RNO-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-CEL-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-DME-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-DME-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-DRE-9696264:r:RND3 GTPase cycle", "R-RNO-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-XTR-9696264:r:RND3 GTPase cycle", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-9696270:r:RND2 GTPase cycle", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-1296072:r:Voltage gated Potassium channels", "R-GGA-9696264:r:RND3 GTPase cycle", "R-MMU-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-9696270:r:RND2 GTPase cycle", "R-BTA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-GGA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DME-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-GGA-1296072:r:Voltage gated Potassium channels", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-8951664:r:Neddylation", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-MMU-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-MMU-9696270:r:RND2 GTPase cycle", "R-CEL-8951664:r:Neddylation", "R-RNO-5576890:r:Phase 3 - rapid repolarisation"], "type": "Domain"}, "IPR003132": {"description": "Protein A, Ig-binding domain", "go_ids": ["GO:0019865"], "go_terms": ["GO:0019865:immunoglobulin binding:F"], "name": "Protein_A_Ig-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003133": {"description": "T antigen, Ori-binding", "go_ids": ["GO:0003688", "GO:0006260"], "go_terms": ["GO:0003688:DNA replication origin binding:F", "GO:0006260:DNA replication:P"], "name": "T_Ag_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003134": {"description": "Hs1/Cortactin", "go_ids": [], "go_terms": [], "name": "Hs1_Cortactin", "pathway_ids": ["R-HSA-8856828", "R-HSA-5627123"], "pathways": ["R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5627123:r:RHO GTPases activate PAKs"], "type": "Repeat"}, "IPR003135": {"description": "ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type", "go_ids": [], "go_terms": [], "name": "ATP-grasp_carboxylate-amine", "pathway_ids": ["PWY-6122", "PWY-6277"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis"], "type": "Domain"}, "IPR003136": {"description": "Cytidylate kinase", "go_ids": ["GO:0005524", "GO:0006139", "GO:0036431"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006139:nucleobase-containing compound metabolic process:P", "GO:0036431:dCMP kinase activity:F"], "name": "Cytidylate_kin", "pathway_ids": ["PWY-7205"], "pathways": ["PWY-7205:t:CMP phosphorylation"], "type": "Family"}, "IPR003137": {"description": "PA domain", "go_ids": [], "go_terms": [], "name": "PA_domain", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-MMU-8856828", "R-MMU-9013106", "R-HSA-5689896", "R-HSA-8856828", "R-HSA-5689880", "R-SSC-9013408", "R-MMU-9013408", "R-RNO-9013149", "R-RNO-5357905", "R-SSC-9013026", "R-MMU-9013404", "R-SSC-917977", "R-MMU-5689896", "R-DME-5689896", "R-MMU-5689880", "R-SSC-9013407", "R-RNO-9013408", "R-RNO-9013406", "R-HSA-9013408", "R-RNO-9013404", "R-RNO-917977", "R-SSC-432722", "R-RNO-432722", "R-MMU-9013407", "R-RNO-8963693", "R-HSA-8963693", "R-RNO-9013407", "R-SSC-9013406", "R-RNO-9696273", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-917977", "R-MMU-9013406", "R-MMU-5357905", "R-SSC-9013149", "R-MMU-8963693", "R-HSA-9013026", "R-HSA-917977", "R-RNO-983168", "R-HSA-9013407", "R-SSC-9013148", "R-SSC-9696270", "R-HSA-9725554", "R-SSC-9013404", "R-MMU-8856825", "R-HSA-901032", "R-RNO-9696270", "R-MMU-8980692", "R-MMU-432722", "R-RNO-8980692", "R-HSA-9013106", "R-SSC-8980692", "R-HSA-9013423", "R-HSA-5357905", "R-HSA-9013148", "R-SSC-8856825", "R-RNO-9013106", "R-RNO-8856828", "R-HSA-432722", "R-CEL-8963693", "R-RNO-8856825", "R-HSA-9696270", "R-SSC-9696273", "R-SSC-9013423", "R-HSA-983168", "R-RNO-9013423", "R-SSC-8856828", "R-HSA-8856825", "R-MMU-9013026", "R-MMU-983168", "R-SSC-9013106", "R-HSA-9013406", "R-MMU-9696270", "R-MMU-9696273", "R-MMU-9013149", "R-DME-5689880", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SSC-9013408:r:RHOG GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-SSC-9013026:r:RHOB GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-SSC-917977:r:Transferrin endocytosis and recycling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SSC-9013407:r:RHOH GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SSC-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-SSC-9696270:r:RND2 GTPase cycle", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SSC-8980692:r:RHOA GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SSC-9696273:r:RND1 GTPase cycle", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR003138": {"description": "Picornavirus coat protein VP4", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Pico_P1A", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Family"}, "IPR003139": {"description": "Delta-retroviral matrix protein", "go_ids": ["GO:0005198", "GO:0019013"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019013:viral nucleocapsid:C"], "name": "D_retro_matrix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003140": {"description": "Phospholipase/carboxylesterase/thioesterase", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "PLipase/COase/thioEstase", "pathway_ids": ["R-DDI-203615", "R-MMU-373760", "R-MMU-9648002", "R-SPO-9648002", "R-SCE-9648002", "R-SCE-203615", "R-RNO-373760", "R-MMU-203615", "R-RNO-9648002", "R-HSA-9648002", "R-DDI-9648002", "R-HSA-373760", "R-HSA-203615", "R-RNO-203615", "R-SPO-203615"], "pathways": ["R-DDI-203615:r:eNOS activation", "R-MMU-373760:r:L1CAM interactions", "R-MMU-9648002:r:RAS processing", "R-SPO-9648002:r:RAS processing", "R-SCE-9648002:r:RAS processing", "R-SCE-203615:r:eNOS activation", "R-RNO-373760:r:L1CAM interactions", "R-MMU-203615:r:eNOS activation", "R-RNO-9648002:r:RAS processing", "R-HSA-9648002:r:RAS processing", "R-DDI-9648002:r:RAS processing", "R-HSA-373760:r:L1CAM interactions", "R-HSA-203615:r:eNOS activation", "R-RNO-203615:r:eNOS activation", "R-SPO-203615:r:eNOS activation"], "type": "Domain"}, "IPR003141": {"description": "Polymerase/histidinol phosphatase, N-terminal", "go_ids": [], "go_terms": [], "name": "Pol/His_phosphatase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003142": {"description": "Biotin protein ligase, C-terminal", "go_ids": ["GO:0036211"], "go_terms": ["GO:0036211:protein modification process:P"], "name": "BPL_C", "pathway_ids": ["R-HSA-196780", "R-SPO-196780", "R-MMU-196780", "R-HSA-3371599"], "pathways": ["R-HSA-196780:r:Biotin transport and metabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency"], "type": "Domain"}, "IPR003143": {"description": "Cytochrome cd1-nitrite reductase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Cyt_cd1_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR003146": {"description": "Carboxypeptidase, activation peptide", "go_ids": [], "go_terms": [], "name": "M14A_act_pep", "pathway_ids": ["R-MMU-977606", "R-HSA-977606", "R-BTA-2022377", "R-RNO-977606", "R-MMU-2022377", "R-RNO-2022377", "R-HSA-9925561", "R-HSA-2022377", "R-BTA-977606"], "pathways": ["R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-BTA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-BTA-977606:r:Regulation of Complement cascade"], "type": "Domain"}, "IPR003147": {"description": "Protein L, Ig light chain-binding", "go_ids": [], "go_terms": [], "name": "B1_Ig_chn-bd", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR003148": {"description": "Regulator of K+ conductance, N-terminal lobe", "go_ids": ["GO:0006813"], "go_terms": ["GO:0006813:potassium ion transport:P"], "name": "RCK_N", "pathway_ids": ["R-MMU-1300642", "R-RNO-1300642", "R-DME-1300642", "R-HSA-418457", "R-HSA-9662360", "R-PFA-5576890", "R-HSA-1300642", "R-HSA-9667769", "R-CEL-1300642", "R-HSA-1296052", "R-DRE-1296052", "R-MMU-1296052", "R-DRE-1300642", "R-BTA-1296052", "R-RNO-1296052", "R-PFA-381676"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-RNO-1300642:r:Sperm Motility And Taxes", "R-DME-1300642:r:Sperm Motility And Taxes", "R-HSA-418457:r:cGMP effects", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-PFA-5576890:r:Phase 3 - rapid 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"R-HSA-8856825", "R-MMU-5654727", "R-MMU-983168", "R-MMU-5654733", "R-MMU-6807004", "R-HSA-5654733", "R-HSA-8875360", "R-HSA-9680350"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-182971:r:EGFR downregulation", "R-MMU-1433559:r:Regulation of KIT signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-912631:r:Regulation of signaling by CBL", "R-HSA-182971:r:EGFR downregulation", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells"], "type": "Domain"}, "IPR003154": {"description": "S1/P1 nuclease", "go_ids": ["GO:0003676", "GO:0004519", "GO:0006308"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0004519:endonuclease activity:F", "GO:0006308:DNA catabolic process:P"], "name": "S1/P1nuclease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003156": {"description": "DHHA1 domain", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "DHHA1_dom", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR003157": {"description": "Acyl transferase, LuxD", "go_ids": ["GO:0006631", "GO:0016746"], "go_terms": ["GO:0006631:fatty acid metabolic process:P", "GO:0016746:acyltransferase activity:F"], "name": "LuxD", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR003158": {"description": "Photosynthetic reaction centre, cytochrome c subunit", "go_ids": ["GO:0005506", "GO:0009055", "GO:0019684", "GO:0020037", "GO:0030077"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0009055:electron transfer activity:F", "GO:0019684:photosynthesis, light reaction:P", "GO:0020037:heme binding:F", "GO:0030077:plasma membrane light-harvesting complex:C"], "name": "Photosyn_RC_cyt_c-su", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003159": {"description": "Polysaccharide lyase family 8, central domain", "go_ids": ["GO:0005576", "GO:0016829"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0016829:lyase activity:F"], "name": "Lyase_8_central_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003162": {"description": "Transcription initiation factor TAFII31", "go_ids": ["GO:0006352"], "go_terms": ["GO:0006352:DNA-templated transcription initiation:P"], "name": "TFIID-31", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-HSA-6807505", "R-BTA-73776", "R-RNO-6807505", "R-SCE-75953", "R-RNO-674695", "R-DME-76042", "R-RNO-73779", "R-MMU-75953", "R-HSA-5689880", "R-BTA-76042", "R-SPO-6807505", "R-MMU-6804756", "R-DME-73779", "R-RNO-73776", "R-HSA-167162", "R-MMU-5689880", "R-SCE-6807505", "R-SPO-76042", "R-DME-73776", "R-HSA-73776", "R-BTA-6804756", "R-HSA-75953", "R-CEL-75953", "R-RNO-6804756", "R-MMU-73776", "R-DME-75953", "R-MMU-73779", "R-CEL-73776", "R-HSA-167172", "R-MMU-76042", "R-SPO-75953", "R-BTA-73779", "R-SCE-73779", "R-CEL-6807505", "R-BTA-75953", "R-DME-674695", "R-RNO-76042", "R-BTA-674695", "R-MMU-674695", "R-MMU-6807505", "R-RNO-5689880", "R-SCE-76042", "R-DME-6804756", "R-CEL-674695", "R-HSA-167161", "R-DME-6807505", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-3214847", "R-HSA-76042", "R-HSA-674695", "R-BTA-6807505", "R-SPO-73776", "R-CEL-76042", "R-RNO-75953", "R-DME-5689880", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-5689880:r:Ub-specific processing proteases", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Family"}, "IPR003164": {"description": "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain", "go_ids": ["GO:0006886", "GO:0016192", "GO:0030131"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P", "GO:0030131:clathrin adaptor complex:C"], "name": "Clathrin_a-adaptin_app_sub_C", "pathway_ids": ["R-HSA-6798695", "R-RNO-5140745", "R-MMU-8856828", "R-HSA-2132295", "R-DME-416993", "R-SPO-6798695", "R-SPO-437239", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-5099900", "R-HSA-9918485", "R-BTA-416993", "R-DME-8866427", "R-BTA-6798695", "R-RNO-416993", "R-DDI-437239", "R-RNO-8964038", "R-DDI-8856825", "R-DME-5099900", "R-SPO-8964038", "R-DDI-8866427", "R-SPO-8856825", "R-MMU-8964038", "R-MMU-2132295", "R-RNO-177504", "R-DDI-8856828", "R-DME-3928665", "R-DME-8856828", "R-RNO-8856828", "R-BTA-437239", "R-HSA-5140745", "R-DME-8964038", "R-RNO-5099900", "R-DME-177504", "R-BTA-8866427", "R-DDI-8964038", "R-RNO-8866427", "R-BTA-2132295", "R-MMU-416993", "R-BTA-8856828", "R-DME-8856825", "R-DDI-6798695", "R-HSA-416993", "R-MMU-437239", "R-RNO-2132295", "R-RNO-8856825", "R-RNO-437239", "R-DME-437239", "R-BTA-5099900", "R-DME-6798695", "R-DME-5140745", "R-HSA-167590", "R-HSA-437239", "R-HSA-5099900", "R-HSA-9679191", "R-SPO-8856828", "R-MMU-5140745", "R-BTA-177504", "R-HSA-177504", "R-HSA-8866427", "R-BTA-8856825", "R-BTA-8964038", "R-HSA-8856825", "R-HSA-3928665", "R-MMU-8866427", "R-MMU-177504", "R-SPO-8866427", "R-MMU-6798695", "R-BTA-5140745", "R-HSA-8964038", "R-RNO-6798695", "R-HSA-182218"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-437239:r:Recycling pathway of L1", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DDI-437239:r:Recycling pathway of L1", "R-RNO-8964038:r:LDL clearance", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-8964038:r:LDL clearance", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8964038:r:LDL clearance", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DME-8964038:r:LDL clearance", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-DDI-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-BTA-2132295:r:MHC class II antigen presentation", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-437239:r:Recycling pathway of L1", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-8964038:r:LDL clearance", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Domain"}, "IPR003165": {"description": "Piwi domain", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "Piwi", "pathway_ids": ["R-HSA-8853884", "R-HSA-426486", "R-SPO-426496", "R-RNO-203927", "R-MMU-426496", "R-HSA-2559580", "R-HSA-9022692", "R-HSA-8936459", "R-HSA-5578749", "R-HSA-2559585", "R-HSA-8948700", "R-DME-5578749", "R-HSA-5628897", "R-HSA-1912408", "R-XTR-426496", "R-HSA-9764562", "R-DRE-426496", "R-SPO-5578749", "R-SPO-426486", "R-HSA-203927", "R-HSA-9845323", "R-CEL-203927", "R-HSA-9759811", "R-HSA-4086398", "R-HSA-9824594", "R-HSA-9029569", "R-HSA-9018519", "R-HSA-5601884", "R-XTR-5578749", "R-CEL-426486", "R-MMU-5578749", "R-HSA-9839394", "R-HSA-8943723", "R-RNO-426496", "R-HSA-8934593", "R-RNO-5578749", "R-MMU-426486", "R-RNO-426486", "R-HSA-9725371", "R-MMU-203927", "R-HSA-9768778", "R-DME-203927", "R-HSA-5687128", "R-XTR-426486", "R-HSA-9820841", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-426496", "R-DME-426496", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-SPO-426496:r:Post-transcriptional silencing by small RNAs", "R-RNO-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-XTR-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-DRE-426496:r:Post-transcriptional silencing by small RNAs", "R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-XTR-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-RNO-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR003166": {"description": "Transcription factor TFIIE beta subunit, DNA-binding domain", "go_ids": ["GO:0006367"], "go_terms": ["GO:0006367:transcription initiation at RNA polymerase II promoter:P"], "name": "TFIIE_bsu_DNA-bd", "pathway_ids": ["R-SCE-73779", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-DDI-73779", "R-SCE-75953", "R-SPO-6807505", "R-DDI-73776", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-HSA-167162", "R-HSA-167161", "R-DDI-6807505", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-HSA-73779", "R-DDI-674695", "R-HSA-75953", "R-SCE-674695", "R-SPO-73779", "R-MMU-73776", "R-DDI-76042", "R-HSA-76042", "R-HSA-674695", "R-DDI-75953", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-SPO-73776", "R-SPO-75953", "R-SCE-73776"], "pathways": ["R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167161:r:HIV Transcription Initiation", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR003168": {"description": "Nitrile hydratase, beta subunit", "go_ids": ["GO:0018822", "GO:0046914"], "go_terms": ["GO:0018822:nitrile hydratase activity:F", "GO:0046914:transition metal ion binding:F"], "name": "Nitrile_hydratase_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003169": {"description": "GYF domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "GYF", "pathway_ids": ["R-HSA-9918481"], "pathways": ["R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR003170": {"description": "UDP-N-acetylenolpyruvoylglucosamine reductase", "go_ids": ["GO:0008762"], "go_terms": ["GO:0008762:UDP-N-acetylmuramate dehydrogenase activity:F"], "name": "MurB", "pathway_ids": ["PWY-7953", "PWY-6387", "PWY-6386"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "type": "Family"}, "IPR003171": {"description": "Methylenetetrahydrofolate reductase-like, catalytic domain", "go_ids": ["GO:0004489", "GO:0006555"], "go_terms": ["GO:0004489:methylenetetrahydrofolate reductase [NAD(P)H] activity:F", "GO:0006555:L-methionine metabolic process:P"], "name": "Mehydrof_redctse-like", "pathway_ids": ["PWY-3841", "PWY-2201", "R-SCE-196757", "R-SPO-196757", "R-HSA-196757", "R-MMU-196757", "R-CEL-196757"], "pathways": ["PWY-3841:t:folate transformations II (plants)", "PWY-2201:t:folate transformations I", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Domain"}, "IPR003172": {"description": "MD-2-related lipid-recognition domain", "go_ids": [], "go_terms": [], "name": "ML_dom", "pathway_ids": ["R-SSC-8964038", "R-HSA-6798695", "R-MMU-9840310", "R-SPO-6798695", "R-SSC-6798695", "R-DRE-8964038", "R-HSA-166016", "R-CEL-6798695", "R-SCE-6798695", "R-HSA-9824878", "R-BTA-6798695", "R-MMU-937072", "R-MMU-166166", "R-HSA-936964", "R-SPO-8964038", "R-DRE-6798695", "R-MMU-9707616", "R-MMU-8964038", "R-HSA-937041", "R-MMU-975163", "R-HSA-9833110", "R-DDI-8964038", "R-HSA-5686938", "R-SCE-8964038", "R-HSA-937072", "R-HSA-9918481", "R-MMU-9824878", "R-MMU-936964", "R-DDI-6798695", "R-MMU-140534", "R-HSA-166058", "R-MMU-166016", "R-HSA-9840310", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-166166", "R-HSA-9820960", "R-HSA-2562578", "R-BTA-8964038", "R-CEL-8964038", "R-MMU-6798695", "R-MMU-2562578", "R-HSA-1236974", "R-HSA-5603041", "R-HSA-140534", "R-HSA-5602498", "R-MMU-937041", "R-HSA-8964038", "R-HSA-975163"], "pathways": ["R-SSC-8964038:r:LDL clearance", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-DRE-8964038:r:LDL clearance", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-SPO-8964038:r:LDL clearance", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-9707616:r:Heme signaling", "R-MMU-8964038:r:LDL clearance", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9833110:r:RSV-host interactions", "R-DDI-8964038:r:LDL clearance", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-SCE-8964038:r:LDL clearance", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-BTA-8964038:r:LDL clearance", "R-CEL-8964038:r:LDL clearance", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-8964038:r:LDL clearance", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Domain"}, "IPR003173": {"description": "Transcriptional coactivator p15 (PC4), C-terminal", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "PC4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003174": {"description": "Alpha trans-inducing protein (Alpha-TIF)", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Alpha_TIF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003175": {"description": "Cyclin-dependent kinase inhibitor domain", "go_ids": ["GO:0004861", "GO:0005634", "GO:0051726"], "go_terms": ["GO:0004861:cyclin-dependent protein serine/threonine kinase inhibitor activity:F", "GO:0005634:nucleus:C", "GO:0051726:regulation of cell cycle:P"], "name": "CDI_dom", "pathway_ids": ["R-HSA-69563", "R-HSA-9607240", "R-HSA-187577", "R-MMU-187577", "R-HSA-5625900", "R-MMU-9607240", "R-MMU-198323", "R-HSA-8951664", "R-MMU-8852276", "R-HSA-69202", "R-MMU-8849470", "R-HSA-2559582", "R-HSA-69231", "R-HSA-9617828", "R-HSA-2559586", "R-HSA-198323", "R-MMU-69202", "R-HSA-69656", "R-HSA-8849470", "R-HSA-8941855", "R-MMU-6804116", "R-HSA-9616222", "R-HSA-8878166", "R-HSA-9825892", "R-CEL-69231", "R-HSA-9661069", "R-HSA-8866911", "R-HSA-5674400", "R-MMU-2559586", "R-HSA-8852276", "R-MMU-2559582", "R-HSA-9755511", "R-HSA-6804116", "R-HSA-69895", "R-HSA-6785807", "R-HSA-9634638", "R-HSA-9703465", "R-MMU-69563", "R-MMU-69656", "R-MMU-9616222", "R-MMU-9634638", "R-HSA-9725370", "R-HSA-9702518", "R-MMU-69231"], "pathways": ["R-HSA-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-9607240:r:FLT3 Signaling", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-MMU-9607240:r:FLT3 Signaling", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-8951664:r:Neddylation", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-MMU-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-CEL-69231:r:Cyclin D associated events in G1", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-MMU-69563:r:p53-Dependent G1 DNA Damage Response", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Domain"}, "IPR003176": {"description": "Adenovirus DNA-binding, all-alpha domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Adenovirus_DNA-bd_a", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003177": {"description": "Cytochrome c oxidase subunit VIIa, metazoa", "go_ids": ["GO:0006123"], "go_terms": ["GO:0006123:mitochondrial electron transport, cytochrome c to oxygen:P"], "name": "Cytc_oxidase_su7a_met", "pathway_ids": ["R-SSC-611105", "R-DRE-611105", "R-DME-9707564", "R-SSC-5628897", "R-DRE-9864848", "R-RNO-5628897", "R-SSC-9864848", "R-RNO-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-BTA-5628897", "R-DME-611105", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-SSC-9707564", "R-DME-9864848", "R-HSA-9844594", "R-BTA-611105", "R-HSA-9707564", "R-MMU-5628897", "R-MMU-611105", "R-MMU-9864848", "R-DRE-9707564", "R-DME-5628897", "R-MMU-9707564", "R-DRE-5628897", "R-BTA-9707564"], "pathways": ["R-SSC-611105:r:Respiratory electron transport", "R-DRE-611105:r:Respiratory electron transport", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-611105:r:Respiratory electron transport", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-SSC-9707564:r:Cytoprotection by HMOX1", "R-DME-9864848:r:Complex IV assembly", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-BTA-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-9864848:r:Complex IV assembly", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR003178": {"description": "Methyl-coenzyme M reductase, gamma subunit", "go_ids": ["GO:0015948", "GO:0050524"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_gsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003179": {"description": "Methyl-coenzyme M reductase, beta subunit", "go_ids": ["GO:0015948", "GO:0050524"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003180": {"description": "Methylpurine-DNA glycosylase", "go_ids": ["GO:0003677", "GO:0003905", "GO:0006284"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003905:alkylbase DNA N-glycosylase activity:F", "GO:0006284:base-excision repair:P"], "name": "MPG", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-RNO-110331", "R-HSA-110331", "R-HSA-110330", "R-HSA-110357", "R-MMU-110357", "R-MMU-110331", "R-RNO-110357"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110331:r:Cleavage of the damaged purine", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1"], "type": "Family"}, "IPR003181": {"description": "Large coat protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Como_LCP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003182": {"description": "RNA2 polyprotein", "go_ids": ["GO:0019028", "GO:0046740", "GO:0044219"], "go_terms": ["GO:0019028:viral capsid:C", "GO:0046740:transport of virus in host, cell to cell:P", "GO:0044219:host cell plasmodesma:C"], "name": "RNA2_polyprotein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003183": {"description": "Methyl-coenzyme M reductase, alpha subunit, N-terminal", "go_ids": ["GO:0015948", "GO:0050524"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_asu_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003184": {"description": "Viral chemokine binding protein", "go_ids": [], "go_terms": [], "name": "Orthopox_35kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003185": {"description": "Proteasome activator PA28, N-terminal domain", "go_ids": ["GO:0008537"], "go_terms": ["GO:0008537:proteasome activator complex:C"], "name": "Proteasome_activ_PA28_N", "pathway_ids": ["R-MMU-9907900", "R-BTA-9912633", "R-BTA-1236978", "R-RNO-9907900", "R-HSA-1236978", "R-HSA-8950505", "R-RNO-1236974", "R-RNO-9912633", "R-HSA-9907900", "R-SSC-9907900", "R-MMU-1236974", "R-HSA-9912633", "R-HSA-1236974", "R-MMU-1236978", "R-BTA-1236974", "R-MMU-9912633", "R-RNO-1236978", "R-BTA-9907900"], "pathways": ["R-MMU-9907900:r:Proteasome assembly", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-9907900:r:Proteasome assembly", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-1236974:r:ER-Phagosome pathway", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-9907900:r:Proteasome assembly", "R-SSC-9907900:r:Proteasome assembly", "R-MMU-1236974:r:ER-Phagosome pathway", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-1236974:r:ER-Phagosome pathway", "R-MMU-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-9907900:r:Proteasome assembly"], "type": "Domain"}, "IPR003186": {"description": "Proteasome activator PA28, C-terminal domain", "go_ids": ["GO:0008537"], "go_terms": ["GO:0008537:proteasome activator complex:C"], "name": "PA28_C", "pathway_ids": ["R-MMU-9907900", "R-BTA-9912633", "R-BTA-1236978", "R-RNO-9907900", "R-DDI-9907900", "R-DDI-9912633", "R-HSA-1236978", "R-HSA-8950505", "R-RNO-1236974", "R-RNO-9912633", "R-DDI-1236974", "R-DDI-1236978", "R-HSA-9907900", "R-SSC-9907900", "R-MMU-1236974", "R-HSA-9912633", "R-HSA-1236974", "R-MMU-1236978", "R-BTA-1236974", "R-MMU-9912633", "R-RNO-1236978", "R-BTA-9907900"], "pathways": ["R-MMU-9907900:r:Proteasome assembly", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-9907900:r:Proteasome assembly", "R-DDI-9907900:r:Proteasome assembly", "R-DDI-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-1236974:r:ER-Phagosome pathway", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-1236974:r:ER-Phagosome pathway", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9907900:r:Proteasome assembly", "R-SSC-9907900:r:Proteasome assembly", "R-MMU-1236974:r:ER-Phagosome pathway", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-1236974:r:ER-Phagosome pathway", "R-MMU-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-9907900:r:Proteasome assembly"], "type": "Domain"}, "IPR003187": {"description": "Phospholipase A1", "go_ids": ["GO:0004620", "GO:0006629", "GO:0016020"], "go_terms": ["GO:0004620:glycerophospholipase activity:F", "GO:0006629:lipid metabolic process:P", "GO:0016020:membrane:C"], "name": "PLipase_A1", "pathway_ids": ["PWY-8411", "PWY-8051", "PWY-7783", "PWY-7416", "PWY-8398", "PWY-7417", "PWY-8400", "PWY-8399", "PWY-7409", "PWY-6803", "PWY-8395", "PWY-8356", "PWY-8357", "PWY-8355", "PWY-8396", "PWY-8413", "PWY-8397", "PWY-8053", "PWY-8412", "PWY-8410"], "pathways": ["PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-8051:t:anandamide biosynthesis I", "PWY-7783:t:plasmalogen degradation", "PWY-7416:t:phospholipid remodeling (phosphatidylcholine, yeast)", "PWY-8398:t:alpha-linolenate metabolites biosynthesis", "PWY-7417:t:phospholipid remodeling (phosphatidate, yeast)", "PWY-8400:t:docosahexaenoate metabolites biosynthesis", "PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-7409:t:phospholipid remodeling (phosphatidylethanolamine, yeast)", "PWY-6803:t:phosphatidylcholine acyl editing", "PWY-8395:t:linoleate metabolites biosynthesis", "PWY-8356:t:maresin biosynthesis", "PWY-8357:t:protectin biosynthesis", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-8413:t:representative whole plasma EPA-derived icosanoids", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-8412:t:representative whole plasma DHA-derived icosanoids", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I"], "type": "Family"}, "IPR003188": {"description": "Phosphotransferase system, 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"R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Family"}, "IPR003197": {"description": "Cytochrome b-c1 complex subunit 7", "go_ids": ["GO:0006122"], "go_terms": ["GO:0006122:mitochondrial electron transport, ubiquinol to cytochrome c:P"], "name": "QCR7", "pathway_ids": ["R-SCE-9865878", "R-HSA-611105", "R-HSA-9865881", "R-DDI-611105", "R-MMU-611105", "R-SPO-611105", "R-BTA-9865881", "R-SCE-611105", "R-BTA-611105", "R-MMU-9865881"], 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["R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR003220": {"description": "InsA N-terminal zinc ribbon domain", "go_ids": ["GO:0006313"], "go_terms": ["GO:0006313:DNA transposition:P"], "name": "InsA_N_dom_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003222": {"description": "Antitermination protein", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Antitermntn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003223": {"description": "Flagellin phase1 repressor", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Flag1_repressor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003224": {"description": "RING finger protein Z, zinc finger", "go_ids": ["GO:0003723", "GO:0008270"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0008270:zinc ion binding:F"], "name": "Z_RING_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003225": {"description": "Viral protein of unknown function DUF325", "go_ids": [], "go_terms": [], "name": "DUF325", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003226": {"description": "MYG1 exonuclease", "go_ids": [], "go_terms": [], "name": "MYG1_exonuclease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003228": {"description": "Transcription initiation factor TFIID subunit 12 domain", "go_ids": ["GO:0005669", "GO:0006352"], "go_terms": ["GO:0005669:transcription factor TFIID complex:C", "GO:0006352:DNA-templated transcription initiation:P"], "name": "TFIID_TAF12_dom", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DME-76042", "R-BTA-76042", "R-DDI-73776", "R-MMU-6804756", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-HSA-73776", "R-BTA-6804756", "R-DDI-674695", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-DDI-76042", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-CEL-73776", "R-MMU-76042", "R-BTA-73779", "R-SPO-75953", "R-SCE-73779", "R-BTA-75953", "R-DME-674695", "R-DDI-73779", "R-BTA-674695", "R-MMU-674695", "R-DME-6804756", "R-SCE-76042", "R-HSA-167161", "R-CEL-674695", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-3214847", "R-HSA-76042", "R-HSA-674695", "R-DDI-75953", "R-BTA-73776", "R-SPO-73776", "R-CEL-76042", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR003230": {"description": "D-alanyl carrier protein", "go_ids": ["GO:0019350", "GO:0036370"], "go_terms": ["GO:0019350:teichoic acid biosynthetic process:P", "GO:0036370:D-alanyl carrier activity:F"], "name": "DltC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003231": {"description": "Acyl carrier protein", "go_ids": ["GO:0006633"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P"], "name": "ACP", "pathway_ids": ["R-MMU-9937383", "R-MMU-9857492", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-DME-77289", "R-HSA-9937383", "R-SCE-9857492", "R-DDI-9857492", "R-DDI-77289", "R-DME-611105", "R-HSA-9857492", "R-SCE-77289", "R-SPO-9857492", "R-HSA-611105", "R-DME-9857492", "R-MMU-77289", "R-MMU-611105", "R-SPO-77289", "R-HSA-77289"], "pathways": ["R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9857492:r:Protein lipoylation", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-9857492:r:Protein lipoylation", "R-DDI-9857492:r:Protein lipoylation", "R-DDI-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-611105:r:Respiratory electron transport", "R-HSA-9857492:r:Protein lipoylation", "R-SCE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SPO-9857492:r:Protein lipoylation", "R-HSA-611105:r:Respiratory electron transport", "R-DME-9857492:r:Protein lipoylation", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation"], "type": "Family"}, "IPR003235": {"description": "Nematode insulin-like peptide, beta type", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Nem_insulin-like_b-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003245": {"description": "Phytocyanin domain", "go_ids": ["GO:0009055"], "go_terms": ["GO:0009055:electron transfer activity:F"], "name": "Phytocyanin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003251": {"description": "Rubrerythrin, diiron-binding domain", "go_ids": ["GO:0046872", "GO:0016491"], "go_terms": ["GO:0046872:metal ion binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "Rr_diiron-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003256": {"description": "Large ribosomal subunit protein uL24", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uL24", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-CEL-5389840", "R-HSA-9937383", "R-DRE-5389840", "R-BTA-9937383", "R-BTA-5389840", "R-CEL-9937383", "R-RNO-5419276", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-DME-5389840", "R-RNO-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-DME-9937383", "R-RNO-5389840", "R-DRE-5419276"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR003263": {"description": "CD40 ligand", "go_ids": ["GO:0005164", "GO:0006955", "GO:0016020"], "go_terms": ["GO:0005164:tumor necrosis factor receptor binding:F", "GO:0006955:immune response:P", "GO:0016020:membrane:C"], "name": "CD40L", "pathway_ids": ["R-HSA-5668541", "R-MMU-198933", "R-MMU-5676594", "R-CFA-5668541", "R-RNO-198933", "R-RNO-5668541", "R-MMU-5668541", "R-HSA-5676594", "R-HSA-198933", "R-CFA-198933", "R-RNO-5676594", "R-CFA-5676594"], "pathways": ["R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-CFA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "type": "Family"}, "IPR003265": {"description": "HhH-GPD domain", "go_ids": ["GO:0006284"], "go_terms": ["GO:0006284:base-excision repair:P"], "name": "HhH-GPD_domain", "pathway_ids": ["R-HSA-110357", "R-MMU-5649702", "R-HSA-9656256", "R-SCE-110329", "R-DME-110357", "R-HSA-5649702", "R-MMU-110331", "R-CEL-110329", "R-HSA-110331", "R-HSA-9657050", "R-BTA-110357", "R-MMU-110329", "R-HSA-110329", "R-RNO-110330", "R-HSA-110330", "R-CEL-110357", "R-DME-110330", "R-SPO-110331", "R-MMU-110357", "R-HSA-9630222", "R-HSA-9656255", "R-SCE-110330", "R-MMU-110330", "R-DME-110329", "R-HSA-9608287", "R-RNO-110331", "R-HSA-110328", "R-HSA-9608290", "R-RNO-110357", "R-BTA-110329", "R-DME-110331", "R-RNO-5649702", "R-SPO-110329", "R-SCE-110331", "R-RNO-110329", "R-HSA-9630221"], "pathways": ["R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-9656256:r:Defective OGG1 Substrate Processing", "R-SCE-110329:r:Cleavage of the damaged pyrimidine", "R-DME-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110331:r:Cleavage of the damaged purine", "R-CEL-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-9657050:r:Defective OGG1 Localization", "R-BTA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-CEL-110357:r:Displacement of DNA glycosylase by APEX1", "R-DME-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-SPO-110331:r:Cleavage of the damaged purine", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9630222:r:Defective NTHL1 substrate binding", "R-HSA-9656255:r:Defective OGG1 Substrate Binding", "R-SCE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-DME-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-9608287:r:Defective MUTYH substrate binding", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9608290:r:Defective MUTYH substrate processing", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-BTA-110329:r:Cleavage of the damaged pyrimidine", "R-DME-110331:r:Cleavage of the damaged purine", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-SPO-110329:r:Cleavage of the damaged pyrimidine", "R-SCE-110331:r:Cleavage of the damaged purine", "R-RNO-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-9630221:r:Defective NTHL1 substrate processing"], "type": "Domain"}, "IPR003280": {"description": "Two pore domain potassium channel", "go_ids": ["GO:0005267", "GO:0016020", "GO:0071805"], "go_terms": ["GO:0005267:potassium channel activity:F", "GO:0016020:membrane:C", "GO:0071805:potassium ion transmembrane transport:P"], "name": "2pore_dom_K_chnl", "pathway_ids": ["R-RNO-1299344", "R-DME-1299503", "R-HSA-1299287", "R-MMU-1299287", "R-SCE-1299503", "R-MMU-1299316", "R-SCE-5576886", "R-HSA-1299316", "R-HSA-5576886", "R-CEL-1299316", "R-HSA-1299503", "R-RNO-1299287", "R-MMU-1299503", "R-SCE-1299361", "R-DME-5576886", "R-CEL-5576886", "R-MMU-1299361", "R-HSA-1299308", "R-SCE-1299316", "R-RNO-1299308", "R-HSA-1299361", "R-HSA-1299344", "R-CEL-1299344", "R-CEL-1299503", "R-BTA-1299308", "R-MMU-1299308", "R-MMU-5576886", "R-RNO-5576886", "R-DME-1299344", "R-BTA-5576886", "R-MMU-1299344", "R-RNO-1299316", "R-SCE-1299344", "R-RNO-1299503", "R-SCE-1299308", "R-SCE-1299287"], "pathways": ["R-RNO-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-DME-1299503:r:TWIK related potassium channel (TREK)", "R-HSA-1299287:r:Tandem pore domain halothane-inhibited K+ channel (THIK)", "R-MMU-1299287:r:Tandem pore domain halothane-inhibited K+ channel (THIK)", "R-SCE-1299503:r:TWIK related potassium channel (TREK)", "R-MMU-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-SCE-5576886:r:Phase 4 - resting membrane potential", "R-HSA-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-HSA-5576886:r:Phase 4 - resting membrane potential", "R-CEL-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-HSA-1299503:r:TWIK related potassium channel (TREK)", "R-RNO-1299287:r:Tandem pore domain halothane-inhibited K+ channel (THIK)", "R-MMU-1299503:r:TWIK related potassium channel (TREK)", "R-SCE-1299361:r:TWIK-related alkaline pH activated K+ channel (TALK)", "R-DME-5576886:r:Phase 4 - resting membrane potential", "R-CEL-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1299361:r:TWIK-related alkaline pH activated K+ channel (TALK)", "R-HSA-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-SCE-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-RNO-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-HSA-1299361:r:TWIK-related alkaline pH activated K+ channel (TALK)", "R-HSA-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-CEL-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-CEL-1299503:r:TWIK related potassium channel (TREK)", "R-BTA-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-MMU-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-MMU-5576886:r:Phase 4 - resting membrane potential", "R-RNO-5576886:r:Phase 4 - resting membrane potential", "R-DME-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-BTA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-RNO-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-SCE-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-RNO-1299503:r:TWIK related potassium channel (TREK)", "R-SCE-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-SCE-1299287:r:Tandem pore domain halothane-inhibited K+ channel (THIK)"], "type": "Family"}, "IPR003282": {"description": "Type III secretion system lipoprotein SctJ", "go_ids": ["GO:0009306"], "go_terms": ["GO:0009306:protein secretion:P"], "name": "T3SS_SctJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003284": {"description": "Salmonella virulence plasmid 65kDa B protein", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "Sal_SpvB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003293": {"description": "Nudix hydrolase 6-like", "go_ids": [], "go_terms": [], "name": "Nudix_hydrolase6-like", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-5381", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "PWY-7761"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-5381:t:NAD salvage (plants)", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "PWY-7761:t:NAD salvage pathway II (PNC IV cycle)"], "type": "Family"}, "IPR003298": {"description": "Apical membrane antigen 1", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Apmem_Ag1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003303": {"description": "Filaggrin", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Filaggrin", "pathway_ids": ["R-HSA-9725554", "R-HSA-6798695", "R-HSA-6809371"], "pathways": ["R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Family"}, "IPR003305": {"description": "Carbohydrate-binding, CenC-like", "go_ids": ["GO:0016798"], "go_terms": ["GO:0016798:hydrolase activity, acting on glycosyl bonds:F"], "name": "CenC_carb-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003306": {"description": "WIF domain", "go_ids": [], "go_terms": [], "name": "WIF", "pathway_ids": ["R-CEL-201681", "R-HSA-3772470", "R-HSA-201681", "R-MMU-201681", "R-HSA-4086400", "R-DME-201681"], "pathways": ["R-CEL-201681:r:TCF dependent signaling in response to WNT", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-4086400:r:PCP/CE pathway", "R-DME-201681:r:TCF dependent signaling in response to WNT"], "type": "Domain"}, "IPR003307": {"description": "W2 domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "W2_domain", "pathway_ids": ["R-MMU-450408", "R-SPO-72702", "R-HSA-72731", "R-HSA-9010553", "R-CEL-72702", "R-HSA-9918487", "R-SPO-72731", "R-HSA-156827", "R-HSA-1169408", "R-MMU-72649", "R-MMU-72706", "R-HSA-975956", "R-SCE-72731", "R-HSA-9820865", "R-HSA-166208", "R-MMU-72731", "R-MMU-429947", "R-MMU-72662", "R-HSA-450408", "R-SCE-72702", "R-MMU-975956", "R-MMU-72702", "R-SPO-72706", "R-HSA-429947", "R-MMU-975957", "R-HSA-72662", "R-HSA-72706", "R-RNO-72702", "R-RNO-72731", "R-MMU-1169408", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-HSA-975957", "R-DDI-72731", "R-MMU-166208", "R-HSA-9820841", "R-DME-72702", "R-DDI-72702"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-72649:r:Translation initiation complex formation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-166208:r:mTORC1-mediated signalling", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-MMU-429947:r:Deadenylation of mRNA", "R-MMU-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-MMU-166208:r:mTORC1-mediated signalling", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72702:r:Ribosomal scanning and start codon recognition"], "type": "Domain"}, "IPR003308": {"description": "Integrase, N-terminal zinc-binding domain", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Integrase_Zn-bd_dom_N", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-164843", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164525", "R-HSA-173107", "R-HSA-162594"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Domain"}, "IPR003309": {"description": "SCAN domain", "go_ids": [], "go_terms": [], "name": "SCAN_dom", "pathway_ids": ["R-HSA-9819196", "R-MMU-212436", "R-RNO-212436", "R-HSA-452723", "R-HSA-212436", "R-BTA-212436"], "pathways": ["R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-212436:r:Generic Transcription Pathway", "R-RNO-212436:r:Generic Transcription Pathway", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Domain"}, "IPR003310": {"description": "G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotes", "go_ids": ["GO:0000700", "GO:0006285"], "go_terms": ["GO:0000700:mismatch base pair DNA N-glycosylase activity:F", "GO:0006285:base-excision repair, AP site formation:P"], "name": "TDG-like_euk", "pathway_ids": ["R-SPO-3108214", "R-HSA-110357", "R-HSA-3108214", "R-SPO-110329", "R-HSA-5221030", "R-MMU-110329", "R-HSA-110329", "R-HSA-110328", "R-MMU-3108214", "R-MMU-5221030", "R-MMU-110357", "R-SPO-5221030"], "pathways": ["R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-5221030:r:TET1,2,3 and TDG demethylate DNA", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5221030:r:TET1,2,3 and TDG demethylate DNA", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-SPO-5221030:r:TET1,2,3 and TDG demethylate DNA"], "type": "Family"}, "IPR003311": {"description": "AUX/IAA protein", "go_ids": ["GO:0005634", "GO:0006355"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "AUX_IAA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003313": {"description": "AraC-type arabinose-binding/dimerisation domain", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "AraC-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003314": {"description": "Mu-type HTH domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Mu-type_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003316": {"description": "E2F/DP family, winged-helix DNA-binding domain", "go_ids": ["GO:0005667", "GO:0006355"], "go_terms": ["GO:0005667:transcription regulator complex:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "E2F_WHTH_DNA-bd_dom", "pathway_ids": ["R-MMU-8953750", "R-BTA-69231", "R-HSA-2559580", "R-HSA-69205", "R-DRE-6804116", "R-DME-69231", "R-HSA-2559585", "R-RNO-2173796", "R-HSA-69231", "R-HSA-8953750", "R-BTA-2173796", "R-HSA-139915", "R-HSA-1912408", "R-MMU-1538133", "R-RNO-68911", "R-RNO-6804116", "R-CEL-1538133", "R-HSA-69656", "R-HSA-1538133", "R-MMU-6804116", "R-DME-8953750", "R-HSA-9616222", "R-BTA-8953750", "R-CEL-68911", "R-CEL-69231", "R-MMU-68911", "R-HSA-2173796", "R-BTA-1538133", "R-RNO-1538133", "R-HSA-9661069", "R-HSA-113501", "R-CEL-6804116", "R-HSA-1362300", "R-MMU-2173796", "R-CEL-2173796", "R-HSA-6804116", "R-DME-1538133", "R-RNO-69231", "R-HSA-1362277", "R-HSA-6804114", "R-HSA-111448", "R-DME-2173796", "R-CEL-8953750", "R-HSA-68911", "R-DME-68911", "R-HSA-69202", "R-MMU-69231"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-69231:r:Cyclin D associated events in G1", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-69205:r:G1/S-Specific Transcription", "R-DRE-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-MMU-1538133:r:G0 and Early G1", "R-RNO-68911:r:G2 Phase", "R-RNO-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1538133:r:G0 and Early G1", "R-MMU-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-CEL-68911:r:G2 Phase", "R-CEL-69231:r:Cyclin D associated events in G1", "R-MMU-68911:r:G2 Phase", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-1538133:r:G0 and Early G1", "R-RNO-1538133:r:G0 and Early G1", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DME-1538133:r:G0 and Early G1", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-68911:r:G2 Phase", "R-DME-68911:r:G2 Phase", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Domain"}, "IPR003317": {"description": "Cytochrome ubiquinol oxidase subunit 2", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Cyt-d_oxidase_su2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003318": {"description": "Glycoside hydrolase, family 70, catalytic domain", "go_ids": ["GO:0046527", "GO:0009250"], "go_terms": ["GO:0046527:glucosyltransferase activity:F", "GO:0009250:glucan biosynthetic process:P"], "name": "Glyco_hydro70cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003319": {"description": "ATP synthase YMF19-like, N-terminal", "go_ids": [], "go_terms": [], "name": "YMF19-like_N", "pathway_ids": ["PWY-7980"], "pathways": ["PWY-7980:t:ATP biosynthesis"], "type": "Domain"}, "IPR003321": {"description": "Cytochrome c552", "go_ids": ["GO:0042279", "GO:0042597"], "go_terms": ["GO:0042279:nitrite reductase (cytochrome, ammonia-forming) activity:F", "GO:0042597:periplasmic space:C"], "name": "Cyt_c552", "pathway_ids": ["PWY-5674"], "pathways": ["PWY-5674:t:nitrate reduction IV (dissimilatory)"], "type": "Family"}, "IPR003322": {"description": "Beta-retroviral matrix protein", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "B_retro_matrix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003323": {"description": "OTU domain", "go_ids": [], "go_terms": [], "name": "OTU_dom", "pathway_ids": ["R-DDI-5689896", "R-MMU-5357786", "R-SCE-5689896", "R-BTA-5689896", "R-DRE-195253", "R-HSA-168638", "R-BTA-195253", "R-HSA-5689896", "R-HSA-5689880", "R-HSA-5633231", "R-CEL-5689896", "R-HSA-936440", "R-MMU-8948751", "R-MMU-5357956", "R-MMU-5689896", "R-HSA-5357786", "R-DME-195253", "R-RNO-5689880", "R-MMU-195253", "R-HSA-446193", "R-DME-5689896", "R-MMU-5689880", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357905", "R-XTR-195253", "R-HSA-8948751", "R-DRE-5689896", "R-SPO-5689896", "R-MMU-936440", "R-MMU-168638", "R-RNO-5689896", "R-XTR-5689896", "R-DME-5689880", "R-HSA-195253"], "pathways": ["R-DDI-5689896:r:Ovarian tumor domain proteases", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-SCE-5689896:r:Ovarian tumor domain proteases", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-5633231:r:Defective ALG14 causes ALG14-CMS", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-XTR-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-SPO-5689896:r:Ovarian tumor domain proteases", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Domain"}, "IPR003325": {"description": "TerD domain", "go_ids": [], "go_terms": [], "name": "TerD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003326": {"description": "TRA-1 regulated", "go_ids": [], "go_terms": [], "name": "TRA-1_regulated", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003327": {"description": "Leucine zipper, Myc", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Myc-LZ", "pathway_ids": ["R-HSA-8866911", "R-RNO-8866911", "R-HSA-8951430", "R-BTA-5689880", "R-BTA-8866911", "R-HSA-5689880", "R-HSA-69202", "R-HSA-2894862", "R-HSA-9818749", "R-HSA-6785807", "R-GGA-8866911", "R-RNO-5689880", "R-HSA-9764562", "R-GGA-5689880", "R-MMU-5689880", "R-HSA-9909649", "R-HSA-69656", 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"R-MMU-3232142", "R-RNO-3301854", "R-MMU-4570464", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230", "R-MMU-4085377", "R-MMU-4551638", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-HSA-4570464", "R-RNO-159236", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-MMU-3301854", "R-HSA-4085377", "R-HSA-168325", "R-MMU-170822", "R-RNO-159227", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-RNO-4551638", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-RNO-4085377", "R-RNO-170822", "R-RNO-4570464", "R-RNO-159231", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-191859:r:snRNP Assembly", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid 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"JmjC domain", "go_ids": [], "go_terms": [], "name": "JmjC_dom", "pathway_ids": ["R-RNO-9629569", "R-MMU-1234174", "R-HSA-9819196", "R-HSA-2559580", "R-HSA-9772755", "R-HSA-6802952", "R-HSA-1234174", "R-CEL-9629569", "R-HSA-5693565", "R-MMU-983231", "R-MMU-212300", "R-HSA-5625886", "R-HSA-9841922", "R-SPO-3214842", "R-MMU-5693565", "R-RNO-3214842", "R-MMU-8866911", "R-MMU-3214842", "R-DME-983231", "R-SPO-983168", "R-DRE-9629569", "R-MMU-9772755", "R-HSA-2299718", "R-SCE-983168", "R-CEL-3214842", "R-HSA-9029569", "R-DRE-212300", "R-DRE-2299718", "R-HSA-9018519", "R-DRE-8866911", "R-HSA-9629569", "R-HSA-8866911", "R-HSA-5617472", "R-DRE-3214842", "R-DME-8866911", "R-SPO-2299718", "R-DDI-9629569", "R-MMU-9818564", "R-SPO-9629569", "R-DME-212300", "R-HSA-3214842", "R-HSA-983231", "R-DME-9629569", "R-DME-5625886", "R-GGA-9629569", "R-CEL-2559580", "R-MMU-2559580", "R-SCE-3214842", "R-HSA-212300", "R-MMU-9629569", "R-HSA-9821002", "R-HSA-9818564", "R-DME-3214842", "R-HSA-6782861", "R-SPO-8951664", "R-DRE-1234174", "R-XTR-9629569", "R-BTA-9629569", "R-SCE-2299718"], "pathways": ["R-RNO-9629569:r:Protein hydroxylation", "R-MMU-1234174:r:Cellular response to hypoxia", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-1234174:r:Cellular response to hypoxia", "R-CEL-9629569:r:Protein hydroxylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SPO-3214842:r:HDMs demethylate histones", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-3214842:r:HDMs demethylate histones", "R-MMU-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-MMU-3214842:r:HDMs demethylate histones", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-9629569:r:Protein hydroxylation", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-3214842:r:HDMs demethylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DRE-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-9629569:r:Protein hydroxylation", "R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-DRE-3214842:r:HDMs demethylate histones", "R-DME-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-SPO-2299718:r:Condensation of Prophase Chromosomes", "R-DDI-9629569:r:Protein hydroxylation", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-SPO-9629569:r:Protein hydroxylation", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-9629569:r:Protein 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"go_terms": [], "name": "JmjN", "pathway_ids": ["R-HSA-8866911", "R-HSA-9819196", "R-DRE-3214842", "R-DME-8866911", "R-DME-212300", "R-DME-5625886", "R-HSA-3214842", "R-HSA-9029569", "R-HSA-5693565", "R-MMU-212300", "R-HSA-5625886", "R-MMU-5693565", "R-RNO-3214842", "R-HSA-212300", "R-MMU-8866911", "R-MMU-3214842", "R-HSA-9821002", "R-CEL-3214842", "R-DRE-212300", "R-DRE-8866911", "R-HSA-9018519"], "pathways": ["R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-DRE-3214842:r:HDMs demethylate histones", "R-DME-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-3214842:r:HDMs demethylate histones", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-MMU-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-CEL-3214842:r:HDMs demethylate histones", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR003350": {"description": "CUT domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "CUT_dom", "pathway_ids": ["R-HSA-9925563", "R-MMU-4551638", "R-HSA-210744", "R-HSA-210747", "R-HSA-111465", "R-HSA-9937080", "R-HSA-5655302", "R-HSA-9925561", "R-MMU-111465", "R-HSA-4551638", "R-HSA-8940973", "R-HSA-1839117"], "pathways": ["R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-210747:r:Regulation of gene expression in early pancreatic precursor cells", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR003351": {"description": "Dishevelled protein domain", "go_ids": [], "go_terms": [], "name": "Dishevelled_protein_dom", "pathway_ids": ["R-MMU-8856828", "R-HSA-201681", "R-RNO-4641262", "R-MMU-8856825", "R-HSA-8856828", "R-HSA-5368598", "R-XTR-8856825", "R-MMU-5099900", "R-DME-4641258", "R-DME-350368", "R-MMU-201688", "R-XTR-4641262", "R-DME-4086400", "R-DME-2028269", "R-DME-350376", "R-DME-5099900", "R-DME-350411", "R-DME-4641262", "R-XTR-5099900", "R-RNO-201688", "R-HSA-4641262", "R-DME-5663220", "R-DME-4608870", "R-MMU-4608870", "R-DME-450728", "R-MMU-5663220", "R-XTR-8856828", "R-RNO-4641258", "R-HSA-201688", "R-DME-350369", "R-MMU-2028269", "R-RNO-4086400", "R-HSA-4086400", "R-MMU-4086400", "R-XTR-201688", "R-HSA-5099900", "R-XTR-5663220", "R-DME-350480", "R-XTR-4641258", "R-HSA-9673324", "R-HSA-4641258", "R-RNO-5663220", "R-DME-201688", "R-MMU-4641258", "R-HSA-4608870", "R-DME-209440", "R-HSA-8856825", "R-XTR-4086400", "R-MMU-4641262", "R-HSA-5663220", "R-HSA-2028269", "R-XTR-2028269"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-4641258:r:Degradation of DVL", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-MMU-201688:r:WNT mediated activation of DVL", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-4086400:r:PCP/CE pathway", "R-DME-2028269:r:Signaling by Hippo", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-201688:r:WNT mediated activation of DVL", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-201688:r:WNT mediated activation of DVL", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-MMU-2028269:r:Signaling by Hippo", "R-RNO-4086400:r:PCP/CE pathway", "R-HSA-4086400:r:PCP/CE pathway", "R-MMU-4086400:r:PCP/CE pathway", "R-XTR-201688:r:WNT mediated activation of DVL", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-XTR-4641258:r:Degradation of DVL", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DME-201688:r:WNT mediated activation of DVL", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-4086400:r:PCP/CE pathway", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-2028269:r:Signaling by Hippo", "R-XTR-2028269:r:Signaling by Hippo"], "type": "Domain"}, "IPR003352": {"description": "Phosphotransferase system, EIIC", "go_ids": ["GO:0008982", "GO:0009401", "GO:0016020"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_EIIC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003353": {"description": "Phosphotransferase system, fructose-specific IIB subunit", "go_ids": ["GO:0009401", "GO:0022877"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0022877:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity:F"], "name": "PTS_IIB_fruc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003354": {"description": "Small/middle T-antigen", "go_ids": [], "go_terms": [], "name": "Papo_T_antigen", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003356": {"description": "DNA methylase, adenine-specific", "go_ids": ["GO:0003677", "GO:0008170"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008170:N-methyltransferase activity:F"], "name": "DNA_methylase_A-5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003358": {"description": "tRNA (guanine-N-7) methyltransferase, Trmb type", "go_ids": ["GO:0006400", "GO:0008176"], "go_terms": ["GO:0006400:tRNA modification:P", "GO:0008176:tRNA (guanine(46)-N7)-methyltransferase activity:F"], "name": "tRNA_(Gua-N-7)_MeTrfase_Trmb", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR003359": {"description": "Photosystem I Ycf4, assembly", "go_ids": ["GO:0016020", "GO:0009579", "GO:0015979", "GO:0009522"], "go_terms": ["GO:0016020:membrane:C", "GO:0009579:thylakoid:C", "GO:0015979:photosynthesis:P", "GO:0009522:photosystem I:C"], "name": "PSI_Ycf4_assembly", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003360": {"description": "US22-like", "go_ids": [], "go_terms": [], "name": "US22-like", "pathway_ids": ["R-HSA-9610379", "R-HSA-5357905", "R-HSA-9609690", "R-HSA-9686347", "R-HSA-9833482", "R-HSA-5357786"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling"], "type": "Family"}, "IPR003361": {"description": "Acetaldehyde dehydrogenase", "go_ids": ["GO:0009056", "GO:0008774"], "go_terms": ["GO:0009056:catabolic process:P", "GO:0008774:acetaldehyde dehydrogenase (acetylating) activity:F"], "name": "Acetaldehyde_dehydrogenase", "pathway_ids": ["PWY-5436", "PWY-7085", "PWY-5162", "PWY-5480", "PWY-6587", "PWY-7180", "PWY-8062", "PWY-8060"], "pathways": ["PWY-5436:t:L-threonine degradation IV", "PWY-7085:t:triethylamine degradation", "PWY-5162:t:2-hydroxypenta-2,4-dienoate degradation", "PWY-5480:t:pyruvate fermentation to ethanol I", "PWY-6587:t:pyruvate fermentation to ethanol III", "PWY-7180:t:2-deoxy-alpha-D-ribose 1-phosphate degradation", "PWY-8062:t:sulfoacetaldehyde degradation IV", "PWY-8060:t:2-deoxy-D-ribose degradation I"], "type": "Family"}, "IPR003362": {"description": "Bacterial sugar transferase", "go_ids": [], "go_terms": [], "name": "Bact_transf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003366": {"description": "CUB-like domain", "go_ids": [], "go_terms": [], "name": "CUB-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003367": {"description": "Thrombospondin, type 3-like repeat", "go_ids": ["GO:0005509", "GO:0007155"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0007155:cell adhesion:P"], "name": "Thrombospondin_3-like_rpt", "pathway_ids": ["R-HSA-186797", "R-BTA-216083", "R-HSA-216083", "R-HSA-3000170", "R-RNO-216083", "R-DRE-186797", "R-HSA-5083635", "R-HSA-8936459", "R-HSA-3000178", "R-RNO-186797", "R-HSA-114608", "R-HSA-5173214", "R-MMU-5173214", "R-MMU-216083", "R-MMU-186797", "R-MMU-114608"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-3000170:r:Syndecan interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-114608:r:Platelet degranulation", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-114608:r:Platelet degranulation"], "type": "Repeat"}, "IPR003368": {"description": "Polymorphic outer membrane protein repeat", "go_ids": [], "go_terms": [], "name": "POMP_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR003369": {"description": "Sec-independent protein translocase protein TatA/B/E, N-terminal", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "TatA/B/E_", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003370": {"description": "Chromate transporter", "go_ids": ["GO:0015109", "GO:0015703"], "go_terms": ["GO:0015109:chromate transmembrane transporter activity:F", "GO:0015703:chromate transport:P"], "name": "Chromate_transpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003372": {"description": "Photosystem II PsbL", "go_ids": ["GO:0009539", "GO:0015979", "GO:0016020", "GO:0009523"], "go_terms": ["GO:0009539:photosystem II reaction center:C", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C", "GO:0009523:photosystem II:C"], "name": "PSII_PsbL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003373": {"description": "Ferrous iron transport protein B", "go_ids": ["GO:0006826", "GO:0005525", "GO:0015093", "GO:0016020"], "go_terms": ["GO:0006826:iron ion transport:P", "GO:0005525:GTP binding:F", "GO:0015093:ferrous iron transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "Fe2_transport_prot-B", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR003374": {"description": "ApbE-like superfamily", "go_ids": [], "go_terms": [], "name": "ApbE-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR003375": {"description": "Photosystem I PsaE, reaction centre subunit IV", "go_ids": ["GO:0009538", "GO:0015979", "GO:0009522"], "go_terms": ["GO:0009538:photosystem I reaction center:C", "GO:0015979:photosynthesis:P", "GO:0009522:photosystem I:C"], "name": "PSI_PsaE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003376": {"description": "Peridinin-chlorophyll A binding protein", "go_ids": ["GO:0030076", "GO:0016168"], "go_terms": ["GO:0030076:light-harvesting complex:C", "GO:0016168:chlorophyll binding:F"], "name": "Peridinin-chlorophyll-bd_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003377": {"description": "Cornichon", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "Cornichon", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-RNO-5694530", "R-RNO-204005", "R-CEL-5694530", "R-BTA-5694530", "R-MMU-5694530", "R-CEL-204005", "R-DRE-204005", "R-BTA-204005", "R-DRE-5694530", "R-DME-5694530", "R-HSA-5694530", "R-DME-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-5694530:r:Cargo concentration in the ER", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-CEL-5694530:r:Cargo concentration in the ER", "R-BTA-5694530:r:Cargo concentration in the ER", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-DRE-5694530:r:Cargo concentration in the ER", "R-DME-5694530:r:Cargo concentration in the ER", "R-HSA-5694530:r:Cargo concentration in the ER", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Family"}, "IPR003378": {"description": "Fringe-like, glycosyltransferase domain", "go_ids": ["GO:0016020", "GO:0016757"], "go_terms": ["GO:0016020:membrane:C", "GO:0016757:glycosyltransferase activity:F"], "name": "Fringe-like_glycosylTrfase", "pathway_ids": ["R-HSA-1912420", "R-HSA-5083632", "R-HSA-5083630", "R-HSA-5173214", "R-MMU-913709", "R-MMU-5173214", "R-HSA-5083635", "R-CEL-913709", "R-HSA-9831926", "R-GGA-913709", "R-DME-913709", "R-HSA-9824272", "R-RNO-913709", "R-BTA-913709", "R-HSA-913709"], "pathways": ["R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-HSA-9831926:r:Nephron development", "R-GGA-913709:r:O-linked glycosylation of mucins", "R-DME-913709:r:O-linked glycosylation of mucins", "R-HSA-9824272:r:Somitogenesis", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-BTA-913709:r:O-linked glycosylation of mucins", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Domain"}, "IPR003379": {"description": "Carboxylase, conserved domain", "go_ids": [], "go_terms": [], "name": "Carboxylase_cons_dom", "pathway_ids": ["PWY-6146", "PWY-6142", "PWY-8086", "R-CEL-196780", "R-MMU-70268", "R-SPO-70268", "R-HSA-196780", "R-BTA-196780", "R-MMU-70263", "R-HSA-3371599", "R-MMU-196780", "R-HSA-70268", "R-BTA-70268", "R-SPO-196780", "R-CEL-70268", "R-RNO-196780", "R-HSA-70263", "R-CEL-70263", "R-RNO-70268", "R-BTA-70263", "R-SPO-70263", "R-SCE-70263", "R-SCE-196780", "R-SCE-70268", "R-RNO-70263"], "pathways": ["PWY-6146:t:Methanobacterium thermoautotrophicum biosynthetic metabolism", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "R-CEL-196780:r:Biotin transport and metabolism", "R-MMU-70268:r:Pyruvate metabolism", "R-SPO-70268:r:Pyruvate metabolism", "R-HSA-196780:r:Biotin transport and metabolism", "R-BTA-196780:r:Biotin transport and metabolism", "R-MMU-70263:r:Gluconeogenesis", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-RNO-70268:r:Pyruvate metabolism", "R-BTA-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-SCE-196780:r:Biotin transport and metabolism", "R-SCE-70268:r:Pyruvate metabolism", "R-RNO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR003380": {"description": "SKI/SNO/DAC domain", "go_ids": [], "go_terms": [], "name": "SKI/SNO/DAC", "pathway_ids": ["R-MMU-2173795", "R-HSA-201451", "R-HSA-2173795", "R-MMU-201451"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-201451:r:Signaling by BMP", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-201451:r:Signaling by BMP"], "type": "Domain"}, "IPR003381": {"description": "Shutoff protein L4", "go_ids": ["GO:0039657", "GO:0039704", "GO:0003723"], "go_terms": ["GO:0039657:symbiont-mediated suppression of host gene expression:P", "GO:0039704:viral translational shunt:P", "GO:0003723:RNA binding:F"], "name": "L4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003382": {"description": "Flavoprotein", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Flavoprotein", "pathway_ids": ["R-MMU-196783", "R-SCE-196783", "R-HSA-196783", "R-SPO-499943", "R-DDI-196783"], "pathways": ["R-MMU-196783:r:Coenzyme A biosynthesis", "R-SCE-196783:r:Coenzyme A biosynthesis", "R-HSA-196783:r:Coenzyme A biosynthesis", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-196783:r:Coenzyme A biosynthesis"], "type": "Domain"}, "IPR003383": {"description": "Circovirus capsid protein", "go_ids": ["GO:0019069"], "go_terms": ["GO:0019069:viral capsid assembly:P"], "name": "Circovirus_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003384": {"description": "Hepatitis E virus Orf2, capsid", "go_ids": ["GO:0030430"], "go_terms": ["GO:0030430:host cell cytoplasm:C"], "name": "HEV_Orf2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003385": {"description": "Glycoside hydrolase, family 77", "go_ids": ["GO:0004134", "GO:0005975"], "go_terms": ["GO:0004134:4-alpha-glucanotransferase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_77", "pathway_ids": ["PWY-7238", "PWY-6724", "PWY-6737"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6724:t:starch degradation II", "PWY-6737:t:starch degradation V"], "type": "Family"}, "IPR003386": {"description": "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase", "go_ids": ["GO:0006629", "GO:0016747"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "LACT/PDAT_acylTrfase", "pathway_ids": ["R-BTA-1483115", "R-HSA-8964058", "R-RNO-1483115", "R-SCE-1483115", "R-SCE-8964058", "R-RNO-8964058", "R-HSA-1483115", "R-MMU-1483115", "R-MMU-8964058"], "pathways": ["R-BTA-1483115:r:Hydrolysis of LPC", "R-HSA-8964058:r:HDL remodeling", "R-RNO-1483115:r:Hydrolysis of LPC", "R-SCE-1483115:r:Hydrolysis of LPC", "R-SCE-8964058:r:HDL remodeling", "R-RNO-8964058:r:HDL remodeling", "R-HSA-1483115:r:Hydrolysis of LPC", "R-MMU-1483115:r:Hydrolysis of LPC", "R-MMU-8964058:r:HDL remodeling"], "type": "Family"}, "IPR003387": {"description": "Nodulin", "go_ids": [], "go_terms": [], "name": "Nodulin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003388": {"description": "Reticulon", "go_ids": [], "go_terms": [], "name": "Reticulon", "pathway_ids": ["R-HSA-8849932", "R-HSA-9918487", "R-MMU-193634", "R-HSA-193634", "R-XTR-8849932", "R-RNO-8849932", "R-RNO-193634", "R-MMU-8849932"], "pathways": ["R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-8849932:r:Synaptic adhesion-like molecules"], "type": "Domain"}, "IPR003389": {"description": "Adenovirus packaging protein 1", "go_ids": ["GO:0019073"], "go_terms": ["GO:0019073:viral DNA genome packaging:P"], "name": "Adeno_IVa2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003390": {"description": "DNA integrity scanning protein, DisA, N-terminal", "go_ids": [], "go_terms": [], "name": "DNA_integrity_scan_DisA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003391": {"description": "Adenoviral preterminal protein", "go_ids": ["GO:0003677", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006260:DNA replication:P"], "name": "Adeno_preterminal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003392": {"description": "Patched domain-containing protein, SSD domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "PTHD_SSD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003393": {"description": "Ammonia monooxygenase/particulate methane monooxygenase, subunit A", "go_ids": [], "go_terms": [], "name": "NH3_CH4_mOase_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003394": {"description": "Porin, opacity type", "go_ids": ["GO:0015288", "GO:0016020"], "go_terms": ["GO:0015288:porin activity:F", "GO:0016020:membrane:C"], "name": "Porin_opacity", "pathway_ids": ["R-HSA-202733"], "pathways": ["R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR003395": {"description": "RecF/RecN/SMC, N-terminal", "go_ids": [], "go_terms": [], "name": "RecF/RecN/SMC_N", "pathway_ids": ["R-SCE-3108214", "R-HSA-2468052", "R-SPO-2470946", "R-BTA-2468052", "R-HSA-2467813", "R-HSA-3108214", "R-RNO-2500257", "R-MMU-2467813", "R-RNO-2470946", "R-HSA-2514853", "R-BTA-3108214", "R-RNO-3108214", "R-HSA-1221632", "R-CEL-2299718", "R-BTA-2467813", "R-DDI-2468052", "R-CEL-3108214", "R-BTA-2500257", "R-RNO-2468052", "R-HSA-2299718", "R-SCE-2514853", "R-HSA-9018519", "R-DDI-2470946", "R-CEL-2500257", "R-BTA-2470946", "R-SPO-2500257", "R-SCE-2468052", "R-MMU-2500257", "R-SPO-3108214", "R-HSA-2500257", "R-SPO-2514853", "R-CEL-2470946", "R-HSA-2470946", "R-DDI-2514853", "R-MMU-2514853", "R-DDI-2500257", "R-SCE-2500257", "R-DDI-2299718", "R-MMU-2299718", "R-RNO-2467813", "R-MMU-3108214", "R-CEL-2468052", "R-DDI-3108214", "R-MMU-2468052", "R-MMU-2470946"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage 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{"description": "3 pythase, beta-propeller", "go_ids": ["GO:0016158"], "go_terms": ["GO:0016158:inositol hexakisphosphate 3-phosphatase activity:F"], "name": "B-propeller_Phytase", "pathway_ids": ["PWY-4702"], "pathways": ["PWY-4702:t:phytate degradation I"], "type": "Domain"}, "IPR003432": {"description": "Replication terminator protein", "go_ids": ["GO:0003677", "GO:0006274"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006274:DNA replication termination:P"], "name": "RTP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003433": {"description": "Capsid protein VP4", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Capsid_VP4_densovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003434": {"description": "Arterivirus GP2a envelope protein", "go_ids": [], "go_terms": [], "name": "Arteri_GP2a", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003435": {"description": "Chaperonin-like RbcX", "go_ids": ["GO:0110102", "GO:0044183"], "go_terms": ["GO:0110102:ribulose bisphosphate carboxylase complex assembly:P", "GO:0044183:protein folding chaperone:F"], "name": "Chaperonin_RcbX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003437": {"description": "Glycine dehydrogenase (decarboxylating)", "go_ids": ["GO:0004375", "GO:0006544"], "go_terms": ["GO:0004375:glycine dehydrogenase (decarboxylating) activity:F", "GO:0006544:glycine metabolic process:P"], "name": "GcvP", "pathway_ids": ["R-DDI-6783984", "R-SPO-6783984", "R-MMU-6783984", "R-SCE-6783984", "R-HSA-6783984"], "pathways": ["R-DDI-6783984:r:Glycine degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-6783984:r:Glycine degradation", "R-SCE-6783984:r:Glycine degradation", "R-HSA-6783984:r:Glycine degradation"], "type": "Family"}, "IPR003438": {"description": "Glial cell line-derived neurotrophic factor receptor", "go_ids": ["GO:0038023"], "go_terms": ["GO:0038023:signaling receptor activity:F"], "name": 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PI3K/AKT Signaling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-GGA-1433557:r:Signaling by SCF-KIT"], "type": "Family"}, "IPR003453": {"description": "ABC transport permease subunit MlaE, proteobacteria", "go_ids": [], "go_terms": [], "name": "ABC_MlaE_roteobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003454": {"description": "Monooxygenase component MmoB/DmpM", "go_ids": ["GO:0004497"], "go_terms": ["GO:0004497:monooxygenase activity:F"], "name": "MOase_MmoB_DmpM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003457": {"description": "Mercuric transport protein MerT", "go_ids": ["GO:0015097", "GO:0015694", "GO:0016020"], "go_terms": ["GO:0015097:mercury ion transmembrane transporter activity:F", "GO:0015694:mercury ion transport:P", "GO:0016020:membrane:C"], "name": "Transprt_MerT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003458": {"description": "Bacteriophage T4, Gp38, tail fibre assembly", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp38_tail_assem", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003459": {"description": "Borrelia plasmid, OrfA", "go_ids": [], "go_terms": [], "name": "Borrelia_plasmid_OrfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003460": {"description": "Thermal hysteresis protein YL-1-like", "go_ids": [], "go_terms": [], "name": "ANPY1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003461": {"description": "Keratin", "go_ids": ["GO:0005200", "GO:0005882"], "go_terms": ["GO:0005200:structural constituent of cytoskeleton:F", "GO:0005882:intermediate filament:C"], "name": "Keratin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003462": {"description": "Ornithine cyclodeaminase/mu-crystallin", "go_ids": [], "go_terms": [], "name": "ODC_Mu_crystall", "pathway_ids": ["R-SCE-71064", "R-RNO-71064", "R-MMU-71064", "R-DDI-71064", "R-BTA-71064", "R-HSA-71064", "R-SPO-71064"], "pathways": ["R-SCE-71064:r:Lysine catabolism", "R-RNO-71064:r:Lysine catabolism", "R-MMU-71064:r:Lysine catabolism", "R-DDI-71064:r:Lysine catabolism", "R-BTA-71064:r:Lysine catabolism", "R-HSA-71064:r:Lysine catabolism", "R-SPO-71064:r:Lysine catabolism"], "type": "Family"}, "IPR003463": {"description": "Paralytic/GBP/PSP peptide", "go_ids": [], "go_terms": [], "name": "GBP_PSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003464": {"description": "Muconolactone delta-isomerase", "go_ids": [], "go_terms": [], "name": "Muconolactone_d_Isoase", "pathway_ids": ["PWY-6185"], "pathways": ["PWY-6185:t:4-methylcatechol degradation (ortho cleavage)"], "type": "Family"}, "IPR003465": {"description": "Proteinase inhibitor I20", "go_ids": ["GO:0004867"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F"], "name": "Prot_inh_I20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003467": {"description": "K88 fimbrial minor subunit FaeH", "go_ids": ["GO:0007155", "GO:0009289"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0009289:pilus:C"], "name": "Fimbrial_K88_FaeH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003468": {"description": "Cytochrome c oxidase, monohaem subunit/FixO", "go_ids": [], "go_terms": [], "name": "Cyt_c_oxidase_monohaem-su/FixO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003469": {"description": "Glycoside hydrolase, family 68", "go_ids": ["GO:0009758", "GO:0050053"], "go_terms": ["GO:0009758:carbohydrate utilization:P", "GO:0050053:levansucrase activity:F"], "name": "Glyco_hydro_68", "pathway_ids": ["PWY-822"], "pathways": ["PWY-822:t:fructan biosynthesis"], "type": "Family"}, "IPR003470": {"description": "Adenovirus E3 region protein CR2", "go_ids": [], "go_terms": [], "name": "Adeno_E3_CR2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003471": {"description": "Adenovirus E3 region protein CR1", "go_ids": [], "go_terms": [], "name": "Adeno_E3_CR1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003472": {"description": "Virion membrane protein, poxvirus L1-related", "go_ids": [], "go_terms": [], "name": "Virion_mem_poxvirus_L1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003473": {"description": "Quinolinate synthetase A", "go_ids": ["GO:0008987", "GO:0009435", "GO:0051539"], "go_terms": ["GO:0008987:quinolinate synthetase A activity:F", "GO:0009435:NAD+ biosynthetic process:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "NadA", "pathway_ids": ["PWY-7342", "PWY-5316", "PWY-8277", "PWY-8352"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-8277:t:NAD de novo biosynthesis IV (anaerobic)", "PWY-8352:t:NAD de novo biosynthesis III"], "type": "Family"}, "IPR003474": {"description": "Gluconate transporter", "go_ids": ["GO:0015128", "GO:0016020", "GO:0035429"], "go_terms": ["GO:0015128:gluconate transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0035429:gluconate transmembrane transport:P"], "name": "Glcn_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003475": {"description": "Insect protein of unknown function", "go_ids": [], "go_terms": [], "name": "Insect_Unk", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003476": {"description": "Glycoside hydrolase, family 42", "go_ids": ["GO:0004565", "GO:0005975"], "go_terms": ["GO:0004565:beta-galactosidase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_42", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Family"}, "IPR003477": {"description": "mRNA interferase PemK-like", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "PemK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003478": {"description": "Outer capsid sigma 1s", "go_ids": ["GO:0044003"], "go_terms": ["GO:0044003:symbiont-mediated perturbation of host process:P"], "name": "Capsid_sigma_1s", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003479": {"description": "Pre-hexon-linking protein IIIa", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Hex_IIIa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003481": {"description": "Flagellar hook-associated protein 2, N-terminal", "go_ids": ["GO:0009424"], "go_terms": ["GO:0009424:bacterial-type flagellum hook:C"], "name": "FliD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003482": {"description": "Transcription factor WhiB", "go_ids": [], "go_terms": [], "name": "Whib", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003483": {"description": "Borrelia outer surface protein E/F", "go_ids": [], "go_terms": [], "name": "OspEF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003484": {"description": "N-acyltransferase NodA", "go_ids": ["GO:0016746", "GO:0005829"], "go_terms": ["GO:0016746:acyltransferase activity:F", "GO:0005829:cytosol:C"], "name": "NodA", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR003485": {"description": "Herpesvirus US2, varicellovirus-type", "go_ids": [], "go_terms": [], "name": "Herpes_US2_varicellovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003486": {"description": "Nucleocapsid N protein", "go_ids": ["GO:0019013"], "go_terms": ["GO:0019013:viral nucleocapsid:C"], "name": "Nairo_nucleocap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003487": {"description": "Phosphoprotein, pneumoviral", "go_ids": ["GO:0003968"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F"], "name": "Pprotein_pneumovir", "pathway_ids": ["R-HSA-9828721", "R-HSA-9833110", "R-HSA-9828806", "R-HSA-9820962", "R-HSA-9828642", "R-HSA-9834752", "R-HSA-9820960"], "pathways": ["R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-9828642:r:Respiratory syncytial virus genome transcription", "R-HSA-9834752:r:Respiratory syncytial virus genome replication", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry"], "type": "Family"}, "IPR003488": {"description": "DNA recombination-mediator protein A", "go_ids": ["GO:0009294"], "go_terms": ["GO:0009294:DNA-mediated transformation:P"], "name": "DprA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003489": {"description": "Ribosome hibernation promoting factor/RaiA", "go_ids": ["GO:0044238"], "go_terms": ["GO:0044238:primary metabolic process:P"], "name": "RHF/RaiA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003490": {"description": "Rhabdovirus non-virion protein", "go_ids": [], "go_terms": [], "name": "Rhabd_NV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003491": {"description": "Replication initiation protein-like, C-terminal", "go_ids": [], "go_terms": [], "name": "REP-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003492": {"description": "Batten's disease protein Cln3", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Battenin_disease_Cln3", "pathway_ids": ["R-SPO-9845576", "R-HSA-9845576", "R-SCE-9845576", "R-MMU-9845576"], "pathways": ["R-SPO-9845576:r:Glycosphingolipid transport", "R-HSA-9845576:r:Glycosphingolipid transport", "R-SCE-9845576:r:Glycosphingolipid transport", "R-MMU-9845576:r:Glycosphingolipid transport"], "type": "Family"}, "IPR003494": {"description": "SHS2 domain inserted in FtsA", "go_ids": ["GO:0005515", "GO:0051301"], "go_terms": ["GO:0005515:protein binding:F", "GO:0051301:cell division:P"], "name": "SHS2_FtsA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003495": {"description": "CobW/HypB/UreG, nucleotide-binding domain", "go_ids": [], "go_terms": [], "name": "CobW/HypB/UreG_nucleotide-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003496": {"description": "ABA/WDS induced protein", "go_ids": [], "go_terms": [], "name": "ABA_WDS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003497": {"description": "BRO N-terminal domain", "go_ids": [], "go_terms": [], "name": "BRO_N_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003498": {"description": "Probable DNA packing protein, C-terminal", "go_ids": ["GO:0051276"], "go_terms": ["GO:0051276:chromosome organization:P"], "name": "DNA_pack_C", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Domain"}, "IPR003499": {"description": "Probable DNA packing protein, N-terminal", "go_ids": ["GO:0051276"], "go_terms": ["GO:0051276:chromosome organization:P"], "name": "DNA_pack_N", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Domain"}, "IPR003500": {"description": "Sugar-phosphate isomerase, RpiB/LacA/LacB family", "go_ids": ["GO:0005975", "GO:0016853"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016853:isomerase activity:F"], "name": "RpiB_LacA_LacB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003501": {"description": "Phosphotransferase system, EIIB component, type 2/3", "go_ids": ["GO:0009401", "GO:0008982"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F"], "name": "PTS_EIIB_2/3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003502": {"description": "Interleukin-1 propeptide", "go_ids": ["GO:0005149", "GO:0006954", "GO:0006955"], "go_terms": ["GO:0005149:interleukin-1 receptor binding:F", "GO:0006954:inflammatory response:P", "GO:0006955:immune response:P"], "name": "IL-1_propep", "pathway_ids": ["R-HSA-9020702", "R-MMU-9960525", "R-RNO-9020702", "R-BTA-448706", "R-HSA-9960525", "R-HSA-5620971", "R-MMU-9020702", "R-HSA-9660826", "R-HSA-2559582", "R-HSA-9960519", "R-HSA-6785807", "R-RNO-448706", "R-RNO-5660668", "R-SSC-5620971", "R-HSA-448706", "R-MMU-448706", "R-HSA-5660668", "R-RNO-5620971", "R-BTA-5620971", "R-MMU-9960519", "R-BTA-9020702", "R-MMU-5620971", "R-SSC-448706", "R-SSC-9020702", "R-HSA-6783783", "R-MMU-5660668"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-RNO-9020702:r:Interleukin-1 signaling", "R-BTA-448706:r:Interleukin-1 processing", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-5620971:r:Pyroptosis", "R-MMU-9020702:r:Interleukin-1 signaling", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9960519:r:CASP4-mediated substrate cleavage", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-448706:r:Interleukin-1 processing", "R-RNO-5660668:r:CLEC7A/inflammasome pathway", "R-SSC-5620971:r:Pyroptosis", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-448706:r:Interleukin-1 processing", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-RNO-5620971:r:Pyroptosis", "R-BTA-5620971:r:Pyroptosis", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-5620971:r:Pyroptosis", "R-SSC-448706:r:Interleukin-1 processing", "R-SSC-9020702:r:Interleukin-1 signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-MMU-5660668:r:CLEC7A/inflammasome pathway"], "type": "Domain"}, "IPR003506": {"description": "Chlamydia cysteine-rich outer membrane protein 6", "go_ids": ["GO:0005201"], "go_terms": ["GO:0005201:extracellular matrix structural constituent:F"], "name": "Chlam_OMP6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003507": {"description": "Peptidase family S66", "go_ids": [], "go_terms": [], "name": "S66_fam", "pathway_ids": ["PWY-6470", "PWY-5707", "PWY-5706", "PWY-7614"], "pathways": ["PWY-6470:t:peptidoglycan biosynthesis V (beta-lactam resistance)", "PWY-5707:t:propanethial S-oxide biosynthesis", "PWY-5706:t:alliin metabolism", "PWY-7614:t:methiin metabolism"], "type": "Family"}, "IPR003508": {"description": "CIDE-N domain", "go_ids": ["GO:0006915"], "go_terms": 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"R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SPO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-110312:r:Translesion synthesis by REV1", "R-GGA-110312:r:Translesion synthesis by REV1", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SCE-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SCE-110312:r:Translesion synthesis by REV1", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR003512": {"description": "Bacteriophage M13, G5P, DNA-binding", "go_ids": ["GO:0003697", "GO:0006260"], "go_terms": ["GO:0003697:single-stranded DNA binding:F", "GO:0006260:DNA replication:P"], "name": "Phage_M13_G5P_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003513": {"description": "Scaffold protein B", "go_ids": ["GO:0019069"], "go_terms": ["GO:0019069:viral capsid assembly:P"], "name": "Phage_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003514": {"description": "Microviridae F protein", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Microviridae_protein_F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003515": {"description": "Major spike protein G", "go_ids": ["GO:0044003"], "go_terms": ["GO:0044003:symbiont-mediated perturbation of host process:P"], "name": "Spike_G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003516": {"description": "Fanconi anaemia group A protein", "go_ids": ["GO:0043240", "GO:0036297"], "go_terms": ["GO:0043240:Fanconi anaemia nuclear complex:C", "GO:0036297:interstrand cross-link repair:P"], "name": "FANCA", "pathway_ids": ["R-HSA-6783310", "R-HSA-9833482", "R-MMU-9833482", "R-MMU-6783310"], "pathways": ["R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR003517": {"description": "Cysteine-rich outer membrane protein 3, Chlamydia", "go_ids": ["GO:0005201"], "go_terms": ["GO:0005201:extracellular matrix structural constituent:F"], "name": "Cys-rich_OMP3_Chlamydia", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003519": {"description": "OspF/SpvC", "go_ids": [], "go_terms": [], 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"GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Transcription_factor_COE", "pathway_ids": ["R-HSA-9844594", "R-HSA-9752946", "R-HSA-381340"], "pathways": ["R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR003524": {"description": "Phospho-N-acetylmuramoyl-pentapeptide transferase", "go_ids": ["GO:0008963", "GO:0016020"], "go_terms": ["GO:0008963:phospho-N-acetylmuramoyl-pentapeptide-transferase activity:F", "GO:0016020:membrane:C"], "name": "PNAcMuramoyl-5peptid_Trfase", "pathway_ids": ["PWY-6470", "PWY-6471", "PWY-5265", "PWY-6385"], "pathways": ["PWY-6470:t:peptidoglycan biosynthesis V (beta-lactam resistance)", "PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", 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cascasde", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation"], "type": "Domain"}, "IPR003536": {"description": "Translocated intimin receptor, central domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Transloc_intimin_rcpt_cen_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003539": {"description": "Cytolethal distending toxin B", "go_ids": [], "go_terms": [], "name": "CD_toxinB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003540": {"description": "ADP ribosyltransferase", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "ADP-ribosyltransferase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003542": {"description": "Enterobactin synthetase-like, component D", "go_ids": ["GO:0009239", "GO:0009366", "GO:0016780"], "go_terms": ["GO:0009239:enterobactin biosynthetic process:P", "GO:0009366:enterobactin synthetase complex:C", "GO:0016780:phosphotransferase activity, for other substituted phosphate groups:F"], "name": "Enbac_synth_compD-like", "pathway_ids": ["PWY-6580", "PWY-6350", "PWY-7817", "PWY-7981", "PWY-7819", "PWY-6804", "PWY-7820", "PWY-8248", "PWY-7816", "PWY-7818", "PWY-7815"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-6350:t:archaetidylinositol biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-6804:t:diacylglycerol biosynthesis (PUFA enrichment in oilseed)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. 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"GO:0003720"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0000723:telomere maintenance:P", "GO:0003720:telomerase activity:F"], "name": "Telomerase_RT", "pathway_ids": ["R-MMU-201722", "R-HSA-201722", "R-HSA-9825895", "R-RNO-201722", "R-RNO-171319", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Family"}, "IPR003557": {"description": "Cytochrome c-type biogenesis protein CcmC", "go_ids": ["GO:0015232", "GO:0015886", "GO:0016020", "GO:0017004"], "go_terms": ["GO:0015232:heme transmembrane 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"pathway_ids": ["PWY-6502"], "pathways": ["PWY-6502:t:8-oxo-(d)GTP detoxification I"], "type": "Family"}, "IPR003564": {"description": "Dihydroneopterin triphosphate diphosphatase", "go_ids": ["GO:0008828", "GO:0046656", "GO:0019177"], "go_terms": ["GO:0008828:dATP diphosphatase activity:F", "GO:0046656:folic acid biosynthetic process:P", "GO:0019177:dihydroneopterin triphosphate pyrophosphohydrolase activity:F"], "name": "DHNTPase", "pathway_ids": ["PWY-6147"], "pathways": ["PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I"], "type": "Family"}, "IPR003566": {"description": "T-cell surface glycoprotein CD5", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Tcell_CD5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003567": {"description": "Cytochrome c-type biogenesis protein", "go_ids": ["GO:0015232", "GO:0015886", "GO:0016020", "GO:0017004"], "go_terms": ["GO:0015232:heme transmembrane transporter activity:F", "GO:0015886:heme 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{"description": "Interleukin-6-like", "go_ids": ["GO:0005138", "GO:0030154", "GO:0005576"], "go_terms": ["GO:0005138:interleukin-6 receptor binding:F", "GO:0030154:cell differentiation:P", "GO:0005576:extracellular region:C"], "name": "IL-6-like", "pathway_ids": ["R-HSA-8853884", "R-RNO-112411", "R-BTA-110056", "R-GGA-1059683", "R-HSA-1059683", "R-HSA-9662834", "R-HSA-112411", "R-MMU-112411", "R-RNO-1059683", "R-HSA-2559582", "R-HSA-6785807", "R-HSA-110056", "R-MMU-8957275", "R-RNO-381426", "R-HSA-381426", "R-BTA-8957275", "R-MMU-1059683", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-RNO-110056", "R-BTA-1059683", "R-GGA-8957275", "R-HSA-8957275", "R-MMU-110056", "R-GGA-381426", "R-HSA-6783783", "R-HSA-9660821"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-BTA-110056:r:MAPK3 (ERK1) activation", "R-GGA-1059683:r:Interleukin-6 signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-9662834:r:CD163 mediating 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"R-BTA-9013423", "R-SPO-9013406", "R-HSA-9013423", "R-CFA-5663213", "R-CFA-6811558", "R-SSC-5627123", "R-SPO-9013420", "R-CFA-416572", "R-HSA-9032845", "R-CFA-9748787", "R-SPO-198203", "R-CEL-193648", "R-SCE-5625740", "R-CEL-9013423", "R-SCE-9013409", "R-DDI-2029482", "R-MMU-3928664", "R-RNO-8849471", "R-GGA-5626467", "R-DDI-5687128", "R-MMU-5626467", "R-SCE-9696264", "R-CFA-5625970", "R-DDI-5663213", "R-CFA-182971", "R-RNO-392451", "R-DME-350480", "R-MMU-5625970", "R-DME-5666185", "R-CFA-5627123", "R-SCE-9013106", "R-CEL-3928665", "R-CFA-3928664", "R-SCE-392451", "R-DDI-3928662", "R-BTA-9013404", "R-SSC-983231", "R-DRE-4086400", "R-CEL-9013420", "R-CEL-198203", "R-CFA-2029482", "R-HSA-5663220", "R-DDI-9013404", "R-MMU-525793", "R-CFA-6798695", "R-BTA-1257604", "R-MMU-9013149", "R-DME-9013420", "R-CEL-983231", "R-RNO-5627123", "R-MMU-182971", "R-DME-3928663", "R-CFA-4086400", "R-MMU-389359", "R-HSA-9013422", "R-CFA-2424491", "R-MMU-6785631", "R-CFA-5626467", "R-BTA-9013424", "R-DME-114604", "R-CEL-5627083", "R-CEL-9013424", "R-RNO-9013149", "R-DME-8964616", "R-MMU-9013404", "R-HSA-9013424", "R-DDI-5626467", "R-SSC-9013420", "R-DME-350376", "R-HSA-3928662", "R-DME-4086400", "R-HSA-8849471", "R-MMU-2871796", "R-SPO-9013106", "R-HSA-4420097", "R-DME-9035034", "R-BTA-3928663", "R-DME-2424491", "R-SSC-5663213", "R-CFA-2173791", "R-MMU-9013422", "R-RNO-5625740", "R-SPO-9696273", "R-SCE-9013149", "R-CFA-9013408", "R-RNO-9013424", "R-MMU-5668599", "R-HSA-164944", "R-DRE-209563", "R-SCE-9013420", "R-GGA-5687128", "R-CFA-5627117", "R-DME-5663220", "R-RNO-9013406", "R-CEL-6785631", "R-CEL-9013148", "R-MMU-193634", "R-DDI-193648", "R-MMU-9748787", "R-DRE-416572", "R-DRE-9013106", "R-SPO-9696264", "R-BTA-9035034", "R-DME-8980692", "R-SSC-9013424", "R-SCE-198203", "R-CEL-8985586", "R-HSA-8950505", "R-SSC-525793", "R-HSA-2219530", "R-MMU-445144", "R-CEL-193634", "R-HSA-6785807", "R-DME-2173791", "R-MMU-5627083", "R-RNO-8964616", "R-DME-5687128", "R-RNO-418885", "R-HSA-9013404", "R-SCE-9013148", "R-MMU-8875555", "R-CFA-5663220", "R-HSA-9013149", "R-BTA-193634", "R-DME-445144", "R-CEL-5627123", "R-HSA-8980692", "R-CFA-9013106", "R-CEL-9035034", "R-SPO-9013424", "R-BTA-114604", "R-RNO-8875555", "R-RNO-5689896", "R-DRE-416482", "R-HSA-198203", "R-BTA-9013106", "R-RNO-4420097", "R-DME-5625900", "R-CFA-5218920", "R-SSC-9696264", "R-SCE-9013423", "R-RNO-6785631", "R-SPO-5687128", "R-HSA-5626467", "R-DME-392451", "R-DDI-8849471", "R-SCE-5627123", "R-DME-350368", "R-CFA-9013404", "R-HSA-418885", "R-DDI-9013149", "R-CEL-9013149", "R-HSA-9032759", "R-CEL-418885", "R-CFA-5687128", "R-SCE-9013406", "R-CFA-5668599", "R-CEL-5625740", "R-CFA-6785631", "R-SPO-9013409", "R-HSA-9619229", "R-CFA-525793", "R-CFA-389359", "R-RNO-9013106", "R-BTA-8849471", "R-CFA-983231", "R-DME-350407", "R-DRE-392451", "R-MMU-5666185", "R-HSA-193648", "R-HSA-9013420", "R-BTA-5689896", "R-HSA-5627083", "R-BTA-2173791", "R-SPO-9013425", "R-HSA-4086400", "R-HSA-8964616", "R-CFA-416550", "R-MMU-3928663", "R-MMU-8985586", "R-HSA-1433557", "R-CFA-9013420", "R-DME-5627117", "R-CFA-5689896", "R-CFA-114604", "R-CEL-2029482", "R-MMU-209563", "R-RNO-114604", "R-RNO-5625900", "R-HSA-8985586", "R-HSA-428543", "R-BTA-9013408", "R-GGA-8964616", "R-HSA-5687128", "R-DME-198203", "R-MMU-9013026", "R-SCE-9013419", "R-MMU-2424491", "R-DME-8849471", "R-GGA-182971", "R-MMU-9696270", "R-BTA-5625900", "R-CFA-193648", "R-DRE-3928663", "R-HSA-5627117"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-RNO-5625970:r:RHO GTPases activate KTN1", "R-BTA-198203:r:PI3K/AKT activation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-CFA-3928663:r:EPHA-mediated growth cone collapse", "R-CFA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-9696270:r:RND2 GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CEL-182971:r:EGFR downregulation", "R-SCE-9696273:r:RND1 GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CEL-389359:r:CD28 dependent Vav1 pathway", "R-RNO-193648:r:NRAGE signals death through JNK", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-BTA-5627117:r:RHO GTPases Activate ROCKs", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013407:r:RHOH GTPase cycle", "R-DDI-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-4086400:r:PCP/CE pathway", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-SCE-193648:r:NRAGE signals death through JNK", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-193648:r:NRAGE signals death through JNK", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-BTA-6785631:r:ERBB2 Regulates Cell Motility", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-198203:r:PI3K/AKT activation", "R-RNO-9013420:r:RHOU GTPase cycle", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-GGA-9013424:r:RHOV GTPase cycle", "R-BTA-4086400:r:PCP/CE pathway", "R-CFA-9013424:r:RHOV GTPase cycle", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-5627083:r:RHO GTPases regulate CFTR trafficking", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-SSC-5626467:r:RHO GTPases activate IQGAPs", "R-CFA-5625740:r:RHO GTPases activate PKNs", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-5625970:r:RHO GTPases activate KTN1", "R-SCE-5626467:r:RHO GTPases activate IQGAPs", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-CFA-418885:r:DCC mediated attractive signaling", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-BTA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-BTA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-9748787:r:Azathioprine ADME", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-GGA-9013408:r:RHOG GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DRE-5625970:r:RHO GTPases activate KTN1", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-CFA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-BTA-418885:r:DCC mediated attractive signaling", "R-RNO-3928664:r:Ephrin signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SCE-9696270:r:RND2 GTPase cycle", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-HSA-428540:r:Activation of RAC1", "R-SCE-389359:r:CD28 dependent Vav1 pathway", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-BTA-209563:r:Axonal growth stimulation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-5625970:r:RHO GTPases activate KTN1", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-CEL-8980692:r:RHOA GTPase cycle", "R-CEL-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-SSC-9013408:r:RHOG GTPase cycle", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-CEL-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-DME-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-9748787:r:Azathioprine ADME", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-CEL-525793:r:Myogenesis", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-3928664:r:Ephrin signaling", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-4086400:r:PCP/CE pathway", "R-CFA-9032759:r:NTRK2 activates RAC1", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-GGA-525793:r:Myogenesis", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-8980692:r:RHOA GTPase cycle", "R-CFA-8875555:r:MET activates RAP1 and RAC1", "R-CFA-209563:r:Axonal growth stimulation", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-SCE-9035034:r:RHOF GTPase cycle", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CFA-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-445144:r:Signal transduction by L1", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-SPO-6798695:r:Neutrophil degranulation", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-GGA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-525793:r:Myogenesis", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-193634:r:Axonal growth inhibition (RHOA activation)", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DRE-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SSC-5625970:r:RHO GTPases activate KTN1", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-983231:r:Factors involved in 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attachment and migration", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-CFA-9013420:r:RHOU GTPase cycle", "R-DME-5627117:r:RHO GTPases Activate ROCKs", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-CFA-114604:r:GPVI-mediated activation cascade", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-209563:r:Axonal growth stimulation", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-BTA-9013408:r:RHOG GTPase cycle", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-198203:r:PI3K/AKT activation", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-MMU-2424491:r:DAP12 signaling", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-GGA-182971:r:EGFR downregulation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-BTA-5625900:r:RHO GTPases activate CIT", "R-CFA-193648:r:NRAGE signals death through JNK", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Family"}, "IPR003582": {"description": "ShKT domain", "go_ids": [], "go_terms": [], "name": "ShKT_dom", "pathway_ids": ["R-HSA-6798695", "R-HSA-2129379", "R-CEL-2243919", "R-CEL-5662702", "R-CEL-8941413", "R-CEL-6798695", "R-MMU-6798695", "R-HSA-1566948", "R-MMU-1566948", "R-MMU-2129379", "R-CEL-209968"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-CEL-5662702:r:Melanin biosynthesis", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1566948:r:Elastic fibre formation", "R-MMU-1566948:r:Elastic fibre formation", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-CEL-209968:r:Thyroxine biosynthesis"], "type": "Domain"}, "IPR003583": {"description": "Helix-hairpin-helix DNA-binding motif, class 1", "go_ids": ["GO:0003677", "GO:0006281"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006281:DNA repair:P"], "name": "Hlx-hairpin-Hlx_DNA-bd_motif", "pathway_ids": ["R-BTA-5649702", "R-BTA-110373", "R-HSA-2132295", "R-MMU-5649702", "R-BTA-5689880", "R-RNO-983189", "R-HSA-5689880", "R-DRE-110381", "R-DRE-5649702", "R-MMU-983189", "R-DRE-110373", "R-RNO-110362", "R-MMU-110381", "R-HSA-5649702", "R-DRE-110362", "R-RNO-110381", "R-MMU-5689880", "R-HSA-6811434", "R-MMU-110362", "R-BTA-5651801", "R-MMU-2132295", "R-HSA-9029569", "R-BTA-73930", "R-MMU-6811434", "R-HSA-110373", "R-DRE-5689880", "R-RNO-2132295", "R-RNO-6811434", "R-MMU-5651801", "R-HSA-110362", "R-BTA-110381", "R-HSA-5651801", "R-BTA-110362", "R-RNO-5689880", "R-RNO-5649702", "R-MMU-110373", "R-RNO-73930", "R-HSA-110381", "R-HSA-983189", "R-RNO-5651801", "R-MMU-73930", "R-DRE-5651801", "R-DRE-73930", "R-HSA-73930", "R-RNO-110373"], "pathways": ["R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-BTA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-HSA-2132295:r:MHC class II antigen presentation", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-RNO-983189:r:Kinesins", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-983189:r:Kinesins", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-BTA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-5689880:r:Ub-specific processing proteases", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-RNO-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-983189:r:Kinesins", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "type": "Domain"}, "IPR003585": {"description": "Neurexin/syndecan/glycophorin C", "go_ids": [], "go_terms": [], "name": "Neurexin-like", "pathway_ids": ["R-SSC-3000170", "R-MMU-2024096", "R-HSA-3560783", "R-BTA-3928662", "R-HSA-9918485", "R-HSA-3656237", "R-MMU-8957275", "R-MMU-3000170", "R-HSA-3928662", "R-RNO-2024096", "R-MMU-975634", "R-BTA-8957275", "R-HSA-418990", "R-MMU-381426", "R-SSC-2022928", "R-HSA-381426", "R-MMU-449836", "R-HSA-447043", "R-BTA-1971475", "R-HSA-3000171", "R-HSA-1971475", "R-DME-3928662", "R-HSA-9694614", "R-BTA-975634", "R-HSA-9820960", "R-HSA-3560801", "R-RNO-381426", "R-MMU-420597", "R-HSA-4420332", "R-RNO-6794361", "R-BTA-3000170", "R-HSA-449836", "R-DME-381426", "R-RNO-420597", "R-DME-8957275", "R-DME-1971475", "R-RNO-418990", "R-HSA-6794361", "R-BTA-2024096", "R-HSA-3656253", "R-RNO-8957275", "R-SSC-1971475", "R-BTA-381426", "R-HSA-2024096", "R-RNO-3928662", "R-MMU-2022928", "R-RNO-3000170", "R-HSA-2022928", "R-HSA-9833110", "R-RNO-975634", "R-HSA-420597", "R-BTA-449836", "R-HSA-9918481", "R-DME-2024096", "R-HSA-3000170", "R-SSC-2024096", "R-XTR-418990", "R-MMU-6794361", "R-DRE-6794361", "R-MMU-418990", "R-BTA-2022928", "R-SSC-975634", "R-RNO-1971475", "R-DME-2022928", "R-DME-3000170", "R-RNO-2022928", "R-MMU-3928662", "R-HSA-8957275", "R-MMU-1971475", "R-RNO-449836", "R-HSA-202733", "R-HSA-975634"], "pathways": ["R-SSC-3000170:r:Syndecan interactions", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-2024096:r:HS-GAG degradation", "R-MMU-975634:r:Retinoid metabolism and transport", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-418990:r:Adherens junctions interactions", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-2022928:r:HS-GAG biosynthesis", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-447043:r:Neurofascin interactions", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-9694614:r:Attachment and Entry", "R-BTA-975634:r:Retinoid metabolism and transport", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-6794361:r:Neurexins and neuroligins", "R-BTA-3000170:r:Syndecan interactions", "R-HSA-449836:r:Other interleukin signaling", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-420597:r:Nectin/Necl trans heterodimerization", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-418990:r:Adherens junctions interactions", "R-HSA-6794361:r:Neurexins and neuroligins", "R-BTA-2024096:r:HS-GAG degradation", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2024096:r:HS-GAG degradation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-RNO-3000170:r:Syndecan interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-9833110:r:RSV-host interactions", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-420597:r:Nectin/Necl trans heterodimerization", "R-BTA-449836:r:Other interleukin signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-2024096:r:HS-GAG degradation", "R-HSA-3000170:r:Syndecan interactions", "R-SSC-2024096:r:HS-GAG degradation", "R-XTR-418990:r:Adherens junctions interactions", "R-MMU-6794361:r:Neurexins and neuroligins", "R-DRE-6794361:r:Neurexins and neuroligins", "R-MMU-418990:r:Adherens junctions interactions", "R-BTA-2022928:r:HS-GAG biosynthesis", "R-SSC-975634:r:Retinoid metabolism and transport", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-2022928:r:HS-GAG biosynthesis", "R-DME-3000170:r:Syndecan interactions", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Domain"}, "IPR003586": {"description": "Hint domain C-terminal", "go_ids": [], "go_terms": [], "name": "Hint_dom_C", "pathway_ids": ["R-SCE-917977", "R-HSA-373080", "R-SCE-1222556", "R-DRE-5358346", "R-SCE-77387", "R-MMU-5635838", "R-SCE-9639288", "R-DME-5362798", "R-GGA-5632681", "R-HSA-9937080", "R-GGA-5358346", "R-RNO-5632681", "R-HSA-5632684", "R-DRE-5362798", "R-DME-5632681", "R-DME-209338", "R-DME-209471", "R-MMU-5632681", "R-HSA-5632681", "R-HSA-5362798", "R-HSA-8941284", "R-MMU-5362798", "R-HSA-5635838", "R-DRE-5632681", "R-MMU-5358346", "R-HSA-9758920", "R-HSA-5362768", "R-HSA-9796292", "R-HSA-5658034", "R-RNO-5362798", "R-GGA-5362798", "R-RNO-5358346", "R-HSA-9690406", "R-DME-5358346", "R-HSA-5358346"], "pathways": ["R-SCE-917977:r:Transferrin endocytosis and recycling", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-SCE-77387:r:Insulin receptor recycling", "R-MMU-5635838:r:Activation of SMO", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5632681:r:Ligand-receptor interactions", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-DME-5632681:r:Ligand-receptor interactions", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-5632681:r:Ligand-receptor interactions", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-5635838:r:Activation of SMO", "R-DRE-5632681:r:Ligand-receptor interactions", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-5658034:r:HHAT G278V doesn't palmitoylate Hh-Np", "R-RNO-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Domain"}, "IPR003587": {"description": "Hint domain N-terminal", "go_ids": [], "go_terms": [], "name": "Hint_dom_N", "pathway_ids": ["R-SCE-917977", "R-HSA-373080", "R-SCE-1222556", "R-DDI-76066", "R-DRE-5358346", "R-SCE-77387", "R-MMU-5635838", "R-SCE-9639288", "R-DME-5362798", "R-GGA-5632681", "R-HSA-9937080", "R-GGA-5358346", "R-RNO-5632681", "R-HSA-5632684", "R-DRE-5362798", "R-DME-5632681", "R-DME-209338", "R-DME-209471", "R-MMU-5632681", "R-HSA-5632681", "R-HSA-5362798", "R-HSA-8941284", "R-MMU-5362798", "R-HSA-5635838", "R-DDI-76061", "R-MMU-5358346", "R-DRE-5632681", "R-HSA-9758920", "R-HSA-5362768", "R-HSA-9796292", "R-HSA-5658034", "R-RNO-5362798", "R-GGA-5362798", "R-RNO-5358346", "R-HSA-9690406", "R-DME-5358346", "R-HSA-5358346"], "pathways": ["R-SCE-917977:r:Transferrin endocytosis and recycling", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-SCE-77387:r:Insulin receptor recycling", "R-MMU-5635838:r:Activation of SMO", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5632681:r:Ligand-receptor interactions", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-DME-5632681:r:Ligand-receptor interactions", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-5632681:r:Ligand-receptor interactions", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-5635838:r:Activation of SMO", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DRE-5632681:r:Ligand-receptor interactions", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-5658034:r:HHAT G278V doesn't palmitoylate Hh-Np", "R-RNO-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Domain"}, "IPR003591": {"description": "Leucine-rich repeat, typical subtype", "go_ids": [], "go_terms": [], "name": "Leu-rich_rpt_typical-subtyp", "pathway_ids": ["R-RNO-2022923", "R-HSA-8936459", "R-SPO-5223345", "R-HSA-9010553", "R-HSA-140837", "R-HSA-8951664", "R-SSC-109704", "R-RNO-4641263", "R-HSA-8863795", "R-HSA-9662360", "R-MMU-9707616", "R-HSA-9846298", "R-DME-214869", "R-HSA-937041", "R-DME-214842", "R-HSA-5223345", "R-RNO-5686938", "R-HSA-168138", "R-RNO-5682910", "R-MMU-380259", "R-HSA-2022870", "R-BTA-168142", "R-GGA-5686938", "R-RNO-975163", "R-MMU-5673000", "R-DDI-5673001", "R-HSA-418555", "R-GGA-2022857", "R-HSA-373752", "R-RNO-936964", "R-RNO-438066", "R-DRE-5673000", "R-RNO-2022857", "R-HSA-9820960", "R-HSA-163125", "R-XTR-4641263", "R-HSA-3656244", "R-DME-214874", "R-HSA-8955332", "R-DDI-5674135", "R-HSA-3656225", "R-MMU-216083", "R-RNO-388844", "R-MMU-9696264", "R-DME-9010553", "R-HSA-9609736", "R-CFA-2022870", "R-HSA-168164", "R-RNO-216083", "R-RNO-937072", "R-SSC-168138", "R-DME-214863", "R-HSA-168179", "R-DDI-5674499", "R-HSA-8849932", "R-MMU-166166", "R-HSA-114608", "R-HSA-388844", "R-MMU-2672351", "R-DDI-8876198", "R-MMU-429947", "R-HSA-9013148", "R-SPO-6803207", "R-RNO-2022870", "R-DME-376176", "R-DDI-5689880", "R-MMU-936964", "R-RNO-937041", "R-HSA-9665249", "R-HSA-9696270", "R-HSA-6803207", "R-DME-6798695", "R-HSA-4641263", "R-MMU-1227986", "R-HSA-109704", "R-XTR-5654687", "R-HSA-9707616", "R-BTA-8849932", "R-HSA-6807004", "R-HSA-168142", "R-DDI-5675221", "R-RNO-9824878", "R-CEL-6803207", "R-RNO-9013423", "R-MMU-2022857", "R-HSA-193634", "R-DME-209968", "R-MMU-5654687", "R-CEL-8941413", "R-HSA-428540", "R-RNO-2022854", "R-HSA-5602498", "R-HSA-428890", "R-MMU-168138", "R-RNO-166016", "R-BTA-216083", "R-MMU-937041", "R-RNO-444821", "R-MMU-418555", "R-HSA-3595174", "R-HSA-6798695", "R-MMU-4641263", "R-MMU-76009", "R-MMU-9013106", "R-HSA-9828211", "R-HSA-166016", "R-CEL-6798695", "R-DDI-6803207", "R-BTA-5682910", "R-MMU-2565942", "R-HSA-936964", "R-DDI-8951664", "R-DRE-9013406", "R-MMU-8951664", "R-DDI-5675482", "R-DDI-170968", "R-BTA-2022870", "R-CFA-2024101", "R-RNO-140534", "R-BTA-2022854", "R-DDI-9013423", "R-HSA-9013408", "R-HSA-168176", "R-DME-214844", "R-RNO-5673001", "R-MMU-2022923", "R-DME-193634", "R-RNO-3000178", "R-DRE-9696270", "R-HSA-9652282", "R-MMU-1474228", "R-DDI-1483248", "R-HSA-166058", "R-MMU-5620916", "R-GGA-216083", "R-GGA-1461957", "R-CFA-168138", "R-RNO-163125", "R-HSA-5673001", "R-HSA-3560801", "R-SPO-8980692", "R-RNO-381426", "R-CEL-5223345", "R-HSA-2022854", "R-HSA-4608870", "R-CFA-1474228", "R-MMU-9013406", "R-MMU-8854518", "R-MMU-6798695", "R-HSA-975110", "R-CFA-2022923", "R-RNO-6794361", "R-BTA-5673000", "R-HSA-9013957", "R-MMU-114608", "R-CEL-209968", "R-MMU-8863795", "R-SPO-6798695", "R-HSA-5602571", "R-HSA-9725554", "R-HSA-5654687", "R-DDI-1660499", "R-BTA-3000178", "R-HSA-6794361", "R-GGA-2022854", "R-HSA-2565942", "R-HSA-5602410", "R-HSA-977606", "R-RNO-2024101", "R-DME-9013406", "R-MMU-168181", "R-DME-428890", "R-HSA-9617324", "R-BTA-2024101", "R-HSA-216083", "R-HSA-9013973", "R-DDI-3295583", "R-HSA-9665246", "R-DDI-1660516", "R-MMU-428890", "R-HSA-1227986", "R-HSA-9665233", "R-HSA-983168", "R-CFA-109704", "R-HSA-166166", "R-HSA-975155", "R-HSA-8876493", "R-DRE-9013148", "R-RNO-1971475", "R-HSA-2562578", "R-HSA-438066", "R-HSA-9692916", "R-HSA-9014325", "R-HSA-9013406", "R-CEL-376176", "R-HSA-380259", "R-DDI-1169092", "R-HSA-9637628", "R-DME-209442", "R-MMU-177929", "R-HSA-9013409", "R-HSA-2243919", "R-SSC-1679131", "R-HSA-3560783", "R-HSA-3000178", "R-RNO-1474228", "R-HSA-9665251", "R-MMU-9013408", "R-MMU-937072", "R-CEL-5673000", "R-HSA-442982", "R-MMU-380320", "R-RNO-140837", "R-HSA-5673000", "R-DDI-5213460", "R-HSA-168927", "R-HSA-199418", "R-MMU-9652282", "R-DDI-5673000", "R-DRE-2022854", "R-GGA-517856", "R-HSA-5602415", "R-MMU-5620912", "R-MMU-5673001", "R-HSA-1474228", "R-MMU-1679131", "R-BTA-1971475", "R-RNO-5673000", "R-RNO-2562578", "R-HSA-429947", "R-BTA-1474228", "R-DME-214862", "R-HSA-1971475", "R-DDI-5223345", "R-HSA-2022857", "R-MMU-380270", "R-MMU-5686938", "R-HSA-5602680", "R-HSA-9696264", "R-DRE-8849932", "R-MMU-9013423", "R-MMU-376176", "R-HSA-2022923", "R-MMU-5682910", "R-RNO-9696264", "R-MMU-2024101", "R-HSA-1236974", "R-HSA-9820841", "R-HSA-9013026", "R-HSA-9726840", "R-RNO-6798695", "R-HSA-8857538", "R-HSA-1839117", "R-DDI-446388", "R-HSA-9705671", "R-HSA-9845620", "R-MMU-430116", "R-DDI-199418", "R-MMU-8980692", "R-HSA-3595172", "R-HSA-9824878", "R-HSA-9665737", "R-HSA-9665348", "R-HSA-9013106", "R-MMU-380284", "R-MMU-388844", "R-HSA-9013423", "R-GGA-451514", "R-DRE-2022857", "R-CEL-9010553", "R-HSA-5620916", "R-DRE-9696264", "R-BTA-6794361", "R-CEL-2243919", "R-HSA-9824856", "R-MMU-6803207", "R-HSA-3595177", "R-RNO-9707616", "R-HSA-5686938", "R-MMU-9824878", "R-HSA-975871", "R-DDI-1632852", "R-MMU-977606", "R-MMU-109704", "R-HSA-8985801", "R-MMU-5223345", "R-DDI-392517", "R-HSA-376176", "R-HSA-5602566", "R-HSA-380270", "R-HSA-9665250", "R-HSA-9726842", "R-HSA-5603037", "R-DME-8941413", "R-HSA-9634285", "R-DME-6803207", "R-CFA-444821", "R-SPO-199418", "R-MMU-6807004", "R-MMU-2562578", "R-HSA-140534", "R-HSA-5682910", "R-HSA-446388", "R-DDI-9013404", "R-MMU-9013149", "R-HSA-8875360", "R-BTA-5223345", "R-DDI-354192", "R-MMU-163125", "R-GGA-433822", "R-HSA-6804115", "R-HSA-430116", "R-HSA-380284", "R-RNO-9013149", "R-MMU-9013404", "R-MMU-446388", "R-RNO-5223345", "R-MMU-2243919", "R-HSA-8854518", "R-SPO-9013106", "R-HSA-380320", "R-MMU-3000178", "R-HSA-9926550", "R-HSA-177929", "R-MMU-975163", "R-DDI-1660517", "R-HSA-9665247", "R-GGA-193634", "R-MMU-193634", "R-HSA-1461957", "R-DME-438066", "R-HSA-381426", "R-HSA-5655302", "R-HSA-9664565", "R-DDI-193648", "R-RNO-199418", "R-HSA-2024101", "R-MMU-140534", "R-HSA-9665244", "R-HSA-9665686", "R-MMU-166016", "R-MMU-8849932", "R-MMU-438066", "R-MMU-140837", "R-MMU-1461957", "R-MMU-2022854", "R-GGA-6798695", "R-HSA-9013404", "R-DME-388844", "R-HSA-75892", "R-SPO-9652282", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-9673221", "R-HSA-9620244", "R-HSA-3656243", "R-HSA-4420332", "R-HSA-5603041", "R-MMU-199418", "R-GGA-5654687", "R-MMU-6804115", "R-RNO-8849932", "R-HSA-5617472", "R-MMU-2022870", "R-RNO-430116", "R-HSA-168188", "R-HSA-975138", "R-RNO-9696270", "R-MMU-9010553", "R-DDI-9013149", "R-HSA-9665245", "R-RNO-6804115", "R-MMU-444821", "R-RNO-166166", "R-BTA-114608", "R-DDI-381676", "R-HSA-76009", "R-HSA-168181", "R-SPO-983168", "R-CFA-1971475", "R-RNO-5654687", "R-HSA-9833110", "R-HSA-5620912", "R-HSA-937072", "R-HSA-9918481", "R-DDI-171007", "R-HSA-428542", "R-MMU-6794361", "R-HSA-444821", "R-HSA-9679191", "R-MMU-8985586", "R-DDI-5621575", "R-HSA-1810476", "R-HSA-1679131", "R-HSA-9830674", "R-HSA-428543", "R-HSA-8985586", "R-DDI-983168", "R-DME-5223345", "R-CFA-1679131", "R-MMU-9013026", "R-DDI-168638", "R-MMU-983168", "R-BTA-2022923", "R-MMU-9758274", "R-MMU-9696270", "R-MMU-1971475", "R-DRE-6804115", "R-MMU-8857538", "R-BTA-2022857", "R-HSA-975163"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-5223345:r:Miscellaneous transport and binding events", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-8951664:r:Neddylation", "R-SSC-109704:r:PI3K Cascade", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-9707616:r:Heme signaling", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-5682910:r:LGI-ADAM interactions", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-BTA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-GGA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-5673000:r:RAF activation", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-418555:r:G alpha (s) signalling events", "R-GGA-2022857:r:Keratan sulfate degradation", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DRE-5673000:r:RAF activation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-MMU-216083:r:Integrin cell surface interactions", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9696264:r:RND3 GTPase cycle", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-2022870:r:CS-GAG biosynthesis", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-114608:r:Platelet degranulation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-DME-376176:r:Signaling by ROBO receptors", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-109704:r:PI3K Cascade", "R-XTR-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-9707616:r:Heme signaling", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-CEL-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-DME-209968:r:Thyroxine biosynthesis", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-428540:r:Activation of RAC1", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-216083:r:Integrin cell surface interactions", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-444821:r:Relaxin receptors", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-6798695:r:Neutrophil degranulation", "R-DDI-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-BTA-5682910:r:LGI-ADAM interactions", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-8951664:r:Neddylation", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-MMU-8951664:r:Neddylation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DDI-170968:r:Frs2-mediated activation", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-CFA-2024101:r:CS/DS degradation", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-DME-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-3000178:r:ECM proteoglycans", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-GGA-216083:r:Integrin cell surface interactions", "R-GGA-1461957:r:Beta defensins", "R-CFA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-SPO-8980692:r:RHOA GTPase cycle", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-5223345:r:Miscellaneous transport and binding events", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-CFA-2022923:r:DS-GAG biosynthesis", "R-RNO-6794361:r:Neurexins and neuroligins", "R-BTA-5673000:r:RAF activation", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-MMU-114608:r:Platelet degranulation", "R-CEL-209968:r:Thyroxine biosynthesis", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-6794361:r:Neurexins and neuroligins", "R-GGA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5602410:r:TLR3 deficiency - HSE", 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proteasomal degradation of PD-L1(CD274)", "R-GGA-68949:r:Orc1 removal from chromatin", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DME-4641257:r:Degradation of AXIN", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-5679090:r:Defective ABCG8 causes GBD4 and sitosterolemia", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6811438:r:Intra-Golgi traffic", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-DME-2046105:r:Linoleic acid (LA) metabolism", "R-GGA-110312:r:Translesion synthesis by REV1", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-9824272:r:Somitogenesis", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-8949613:r:Cristae formation", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-1296025:r:ATP sensitive Potassium channels", "R-PFA-9754706:r:Atorvastatin ADME", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-9753281:r:Paracetamol ADME", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-917937:r:Iron uptake and transport", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-CFA-912446:r:Meiotic recombination", 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"R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-2161517:r:Abacavir transmembrane transport", "R-MMU-2142845:r:Hyaluronan metabolism", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-SPO-5689603:r:UCH proteinases", "R-HSA-8949613:r:Cristae formation", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SCE-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-5689877:r:Josephin domain DUBs", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-2132295:r:MHC class II antigen presentation", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5679096:r:Defective ABCG5 causes sitosterolemia", "R-DME-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SCE-159418:r:Recycling of bile acids and salts", "R-DDI-9754706:r:Atorvastatin ADME", "R-GGA-353303:r:Nucleotide Excision Repair", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-216167:r:Nuclear CI is degraded", "R-CEL-6811438:r:Intra-Golgi traffic", "R-DRE-5627083:r:RHO GTPases regulate CFTR trafficking", "R-DDI-2046105:r:Linoleic acid (LA) metabolism", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9907900:r:Proteasome assembly", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-1268020:r:Mitochondrial protein import", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-SPO-69052:r:Switching of origins to a post-replicative state", "R-BTA-5689603:r:UCH proteinases", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-917937:r:Iron uptake and transport", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-9033241:r:Peroxisomal protein import", "R-CEL-4641257:r:Degradation of AXIN", "R-HSA-9913143:r:Antimicrobial resistance", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-CFA-9837999:r:Mitochondrial protein degradation", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9638482:r:Metal ion assimilation from the host", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-8951664:r:Neddylation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1236974:r:ER-Phagosome pathway", "R-GGA-69091:r:Polymerase switching", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9748787:r:Azathioprine ADME", "R-BTA-68949:r:Orc1 removal from chromatin", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8949664:r:Processing of SMDT1", "R-HSA-68877:r:Mitotic Prometaphase", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SSC-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-MMU-189451:r:Heme biosynthesis", "R-HSA-8964058:r:HDL remodeling", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-1369007:r:Mitochondrial ABC transporters", "R-DME-5696400:r:Dual Incision in GG-NER", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SCE-6811438:r:Intra-Golgi traffic", "R-DRE-1369007:r:Mitochondrial ABC transporters", "R-RNO-9646399:r:Aggrephagy", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-176974:r:Unwinding of DNA", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-MMU-189483:r:Heme degradation", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9749641:r:Aspirin ADME", "R-CEL-1369062:r:ABC transporters in lipid homeostasis", "R-DME-1296025:r:ATP sensitive Potassium channels", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-9865881:r:Complex III assembly", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-SPO-6811438:r:Intra-Golgi traffic", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-5689603:r:UCH proteinases", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SPO-9757110:r:Prednisone ADME", "R-BTA-189483:r:Heme degradation", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-CEL-8949613:r:Cristae formation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9749641:r:Aspirin ADME", "R-SPO-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-GGA-912446:r:Meiotic recombination", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-DME-68962:r:Activation of the pre-replicative complex", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-5655862:r:Translesion synthesis by POLK", "R-BTA-69481:r:G2/M Checkpoints", "R-SPO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-CFA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-SPO-9754706:r:Atorvastatin ADME", "R-RNO-3371511:r:HSF1 activation", "R-GGA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DDI-189483:r:Heme degradation", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-RNO-5632684:r:Hedgehog 'on' state", "R-SCE-5689896:r:Ovarian tumor domain proteases", "R-XTR-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-GGA-265976:r:Homologous DNA pairing and strand exchange", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9907900:r:Proteasome assembly", "R-CEL-9748787:r:Azathioprine ADME", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-DRE-9646399:r:Aggrephagy", "R-DME-189451:r:Heme biosynthesis", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DME-5578775:r:Ion homeostasis", "R-XTR-110320:r:Translesion Synthesis by POLH", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CFA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-XTR-68949:r:Orc1 removal from chromatin", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-69091:r:Polymerase switching", "R-RNO-5689877:r:Josephin domain DUBs", "R-HSA-9678110:r:Attachment and Entry", "R-DRE-9013407:r:RHOH GTPase cycle", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-1296025:r:ATP sensitive Potassium channels", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CFA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5678420:r:Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-4641257:r:Degradation of AXIN", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8949664:r:Processing of SMDT1", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-68867:r:Assembly of the pre-replicative complex", "R-RNO-189451:r:Heme biosynthesis", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-SSC-189451:r:Heme biosynthesis", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-CFA-9758890:r:Transport of RCbl within the body", "R-RNO-5689603:r:UCH proteinases", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-HSA-5610787:r:Hedgehog 'off' state", "R-RNO-9754706:r:Atorvastatin ADME", "R-DME-9748787:r:Azathioprine ADME", "R-HSA-5683678:r:Defective ABCA3 causes SMDP3", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-BTA-9907900:r:Proteasome assembly", "R-MMU-5683826:r:Surfactant metabolism", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9753281:r:Paracetamol ADME", "R-CFA-163210:r:Formation of ATP by chemiosmotic coupling", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-8963896:r:HDL assembly", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-XTR-5358346:r:Hedgehog ligand biogenesis", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-PFA-6798695:r:Neutrophil degranulation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-9753281:r:Paracetamol ADME", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-SCE-114608:r:Platelet degranulation", "R-RNO-5610787:r:Hedgehog 'off' state", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DME-2467813:r:Separation of Sister Chromatids", "R-CEL-2142845:r:Hyaluronan metabolism", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SCE-8951664:r:Neddylation", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9927020:r:Heme assimilation", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9749641:r:Aspirin ADME", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DDI-9749641:r:Aspirin ADME", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-9907900:r:Proteasome assembly", "R-RNO-4641257:r:Degradation of AXIN", "R-DDI-5689603:r:UCH proteinases", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689877:r:Josephin domain DUBs", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-DME-6811436:r:COPI-independent 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"R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-GGA-68689:r:CDC6 association with the ORC:origin complex", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-8951664:r:Neddylation", "R-DDI-9646399:r:Aggrephagy", "R-DDI-5632684:r:Hedgehog 'on' state", "R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-5678520:r:Defective ABCB11 causes PFIC2 and BRIC2", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-HSA-5682294:r:Defective ABCA12 causes ARCI4B", "R-CEL-9837999:r:Mitochondrial protein 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activation", "R-BTA-9707564:r:Cytoprotection by HMOX1", "R-HSA-8876725:r:Protein methylation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-73614:r:Pyrimidine salvage", "R-BTA-9758890:r:Transport of RCbl within the body", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-SCE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-CEL-5656169:r:Termination of translesion DNA synthesis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5689603:r:UCH proteinases", "R-RNO-9013106:r:RHOC GTPase cycle", "R-SPO-9753281:r:Paracetamol ADME", "R-SPO-5689896:r:Ovarian tumor domain proteases", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DME-9013407:r:RHOH GTPase cycle", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-GGA-351451:r:Homologous recombination repair of replication-dependent double-strand breaks", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-DDI-69091:r:Polymerase switching", "R-HSA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-432395:r:Degradation of TIM", "R-DME-8949664:r:Processing of SMDT1", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-DME-9793528:r:Ciprofloxacin ADME", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-69091:r:Polymerase switching", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CFA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-9013407:r:RHOH GTPase cycle", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5610787:r:Hedgehog 'off' state", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-189483:r:Heme degradation", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-69052:r:Switching of origins to 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inhibitory signal", "R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-1369007:r:Mitochondrial ABC transporters", "R-RNO-5627083:r:RHO GTPases regulate CFTR trafficking", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-189483:r:Heme degradation", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-912446:r:Meiotic recombination", "R-SPO-1369007:r:Mitochondrial ABC transporters", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SPO-9749641:r:Aspirin ADME", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-8983711:r:OAS antiviral response", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-5690338:r:Defective ABCC6 causes PXE", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-BTA-69091:r:Polymerase switching", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-422356:r:Regulation of insulin secretion", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation 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GLI3R by the proteasome", "R-DRE-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-SSC-1660661:r:Sphingolipid de novo biosynthesis", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-BTA-9033241:r:Peroxisomal protein import", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-110312:r:Translesion synthesis by REV1", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-XTR-6798695:r:Neutrophil degranulation", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SPO-9758890:r:Transport of RCbl within the body", "R-CFA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-8854518:r:AURKA 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"R-DME-5689603:r:UCH proteinases", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-CFA-159418:r:Recycling of bile acids and salts", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-5578775:r:Ion homeostasis", "R-RNO-5683826:r:Surfactant metabolism", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SPO-3371511:r:HSF1 activation", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-69091:r:Polymerase switching", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-68949:r:Orc1 removal from chromatin", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-SCE-9754706:r:Atorvastatin ADME", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-69481:r:G2/M Checkpoints", "R-CFA-8949613:r:Cristae formation", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-5689877:r:Josephin domain DUBs", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-PFA-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-CEL-174411:r:Polymerase switching on the C-strand of the telomere", "R-CFA-9707564:r:Cytoprotection by HMOX1", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-5620924:r:Intraflagellar transport", "R-DME-114608:r:Platelet degranulation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-8964058:r:HDL remodeling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9646399:r:Aggrephagy", "R-MMU-9758890:r:Transport of RCbl within the body", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-8949613:r:Cristae formation", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-9757110:r:Prednisone ADME", "R-HSA-5683177:r:Defective ABCC8 can cause hypo- and hyper-glycemias", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DRE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-CFA-9753281:r:Paracetamol ADME", "R-MMU-8852276:r:The role 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"R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-9646399:r:Aggrephagy", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-9753281:r:Paracetamol ADME", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-204005:r:COPII-mediated 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"R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-SPO-9748787:r:Azathioprine ADME", "R-SPO-68949:r:Orc1 removal from chromatin", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9918454:r:Defective visual phototransduction due to ABCA4 loss of function", "R-SCE-69091:r:Polymerase switching", "R-CFA-1268020:r:Mitochondrial protein import", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-69052:r:Switching of origins to a post-replicative state", "R-DME-5656121:r:Translesion 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"R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-SCE-9748787:r:Azathioprine ADME", "R-DRE-3371511:r:HSF1 activation", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DME-9837999:r:Mitochondrial protein degradation", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-DME-538864:r:Degradation of CRY", "R-RNO-69091:r:Polymerase switching", "R-SCE-9907900:r:Proteasome assembly", "R-MMU-8963896:r:HDL assembly", "R-CEL-68949:r:Orc1 removal from chromatin", 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"R-BTA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-8937144:r:Aryl hydrocarbon receptor signalling", "R-DDI-8939211:r:ESR-mediated signaling", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-844456:r:The NLRP3 inflammasome", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M 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"R-HSA-8943723", "R-MMU-9927353", "R-HSA-5654712", "R-MMU-9706369", "R-HSA-5690714", "R-MMU-1660499", "R-MMU-8873719", "R-CEL-5689880", "R-MMU-5654726", "R-RNO-6807004", "R-GGA-5654712", "R-RNO-5654695", "R-RNO-1660499", "R-HSA-9634285", "R-HSA-201556", "R-HSA-877300", "R-HSA-912526", "R-MMU-5654693", "R-MMU-6807004", "R-MMU-5654689", "R-DRE-1433557", "R-MMU-182971", "R-RNO-5654726", "R-DME-375165", "R-RNO-5654710", "R-GGA-5654727", "R-HSA-432142", "R-RNO-9927353", "R-MMU-1295596", "R-RNO-8849472", "R-CEL-9035034", "R-MMU-9833482", "R-RNO-202424", "R-MMU-5654732", "R-DDI-1660517", "R-HSA-202430", "R-GGA-109704", "R-GGA-8854691", "R-GGA-180292", "R-RNO-199418", "R-RNO-201556", "R-RNO-5654693", "R-CFA-1855204", "R-HSA-8849472", "R-RNO-8853659", "R-MMU-166016", "R-MMU-8849932", "R-GGA-8853659", "R-MMU-8853659", "R-MMU-982772", "R-HSA-5654732", "R-HSA-2219530", "R-MMU-5654700", "R-HSA-8854691", "R-CEL-202424", "R-RNO-77387", "R-GGA-8934593", "R-HSA-982772", "R-DME-388844", "R-RNO-1660517", "R-RNO-389513", "R-HSA-9703648", "R-HSA-5654720", "R-HSA-8948751", "R-MMU-199418", "R-RNO-5689896", "R-HSA-9860927", "R-HSA-9674555", "R-HSA-5654733", "R-RNO-8849932", "R-GGA-5654710", "R-MMU-375165", "R-CEL-375165", "R-HSA-449836", "R-SPO-5687128", "R-HSA-8873719", "R-HSA-9034015", "R-RNO-8934593", "R-HSA-418886", "R-CEL-416700", "R-DME-9860927", "R-HSA-5628897", "R-GGA-6811558", "R-HSA-912694", "R-GGA-389513", "R-SCE-176407", "R-MMU-1855204", "R-HSA-9028731", "R-CFA-202424", "R-RNO-8948747", "R-HSA-354192", "R-MMU-8854691", "R-RNO-112411", "R-HSA-8948747", "R-GGA-210990", "R-DME-77387", "R-MMU-983695", "R-RNO-180292", "R-HSA-1433557", "R-GGA-432142", "R-MMU-877300", "R-RNO-112409", "R-CFA-5689896", "R-HSA-9851151", "R-MMU-176407", "R-RNO-114604", "R-DME-8849932", "R-HSA-5687128", "R-RNO-8873719", "R-RNO-5654720", "R-CEL-1660499", "R-HSA-9022699", "R-MMU-8849472", "R-GGA-512988", "R-MMU-9696270", "R-GGA-437986", "R-RNO-186763", "R-HSA-9696273", "R-HSA-5675221"], "pathways": ["R-DDI-8873719:r:RAB geranylgeranylation", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-77387:r:Insulin receptor recycling", "R-MMU-1632852:r:Macroautophagy", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-GGA-5654695:r:PI-3K cascade:FGFR2", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-201556:r:Signaling by ALK", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-112409:r:RAF-independent MAPK1/3 activation", "R-DME-210693:r:STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-CEL-182971:r:EGFR downregulation", "R-MMU-186763:r:Downstream signal transduction", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-202670:r:ERKs are inactivated", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-GGA-1059683:r:Interleukin-6 signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-202670:r:ERKs are inactivated", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-5674404:r:PTEN Loss of Function in Cancer", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-GGA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-416700:r:Other semaphorin interactions", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-354192:r:Integrin signaling", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1059683:r:Interleukin-6 signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-354192:r:Integrin signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-112409:r:RAF-independent MAPK1/3 activation", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-MMU-202670:r:ERKs are inactivated", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9706369:r:Negative regulation of FLT3", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-109704:r:PI3K Cascade", "R-GGA-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-389948:r:Co-inhibition by PD-1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-9696273:r:RND1 GTPase cycle", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-186797:r:Signaling by PDGF", "R-CEL-8948747:r:Regulation of PTEN localization", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1433559:r:Regulation of KIT signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-HSA-180292:r:GAB1 signalosome", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-6798695:r:Neutrophil degranulation", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-GGA-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-1483248:r:Synthesis of PIPs at the ER membrane", "R-SPO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-8865999:r:MET activates PTPN11", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-GGA-5654720:r:PI-3K cascade:FGFR4", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-1632852:r:Macroautophagy", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DRE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-416700:r:Other semaphorin interactions", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-SPO-1632852:r:Macroautophagy", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-432142:r:Platelet sensitization by LDL", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CFA-8948751:r:Regulation of PTEN stability and activity", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-109704:r:PI3K Cascade", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-CFA-5689880:r:Ub-specific processing proteases", "R-GGA-186763:r:Downstream signal transduction", "R-HSA-210990:r:PECAM1 interactions", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-389948:r:Co-inhibition by PD-1", "R-BTA-1483248:r:Synthesis of PIPs at the ER membrane", "R-CFA-8948747:r:Regulation of PTEN localization", "R-HSA-9645135:r:STAT5 Activation", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-982772:r:Growth hormone receptor signaling", "R-DME-877312:r:Regulation of IFNG signaling", "R-DDI-202670:r:ERKs are inactivated", "R-HSA-186763:r:Downstream signal transduction", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-3000178:r:ECM proteoglycans", "R-GGA-8865999:r:MET activates PTPN11", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-210993:r:Tie2 Signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-GGA-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-1632852:r:Macroautophagy", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210990:r:PECAM1 interactions", "R-CFA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-8853659:r:RET signaling", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-BTA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-GGA-5654689:r:PI-3K cascade:FGFR1", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-112409:r:RAF-independent MAPK1/3 activation", "R-GGA-389948:r:Co-inhibition by PD-1", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-77387:r:Insulin receptor recycling", "R-CEL-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-DDI-1632852:r:Macroautophagy", "R-MMU-109704:r:PI3K Cascade", "R-GGA-210993:r:Tie2 Signaling", "R-RNO-416700:r:Other semaphorin interactions", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", 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"R-RNO-1474228", "R-HSA-9918485", "R-MMU-9013408", "R-MMU-210990", "R-RNO-373753", "R-CEL-3000178", "R-HSA-9856532", "R-HSA-3656237", "R-DME-5654732", "R-SSC-202733", "R-RNO-8863795", "R-HSA-9674401", "R-MMU-5632681", "R-DRE-6811558", "R-CEL-190373", "R-HSA-5140745", "R-MMU-5673001", "R-MMU-449836", "R-HSA-9669917", "R-HSA-9026527", "R-DME-190370", "R-RNO-1566977", "R-RNO-445144", "R-HSA-9674396", "R-HSA-416482", "R-DME-433692", "R-MMU-190372", "R-MMU-5690714", "R-HSA-447041", "R-RNO-5654688", "R-DME-5654695", "R-RNO-879415", "R-MMU-193648", "R-HSA-9749641", "R-HSA-9793380", "R-HSA-445144", "R-HSA-9013026", "R-MMU-5627123", "R-GGA-9749641", "R-BTA-202433", "R-HSA-9664323", "R-DME-373752", "R-MMU-416550", "R-CEL-8849932", "R-HSA-5655253", "R-DME-1358803", "R-XTR-202433", "R-DME-5673001", "R-HSA-416572", "R-GGA-163125", "R-MMU-8980692", "R-HSA-2029485", "R-HSA-9013106", "R-HSA-373760", "R-MMU-388844", "R-HSA-9013423", "R-DRE-190377", "R-HSA-190374", "R-MMU-190370", "R-CEL-190377", "R-CEL-2243919", "R-CFA-6811558", "R-MMU-1250347", "R-CEL-373752", "R-HSA-1250196", "R-HSA-9674404", "R-HSA-2022928", "R-HSA-9669926", "R-DRE-195399", "R-MMU-202424", "R-GGA-1250196", "R-SSC-2029481", "R-MMU-437239", "R-HSA-5655291", "R-MMU-109704", "R-DRE-5654227", "R-RNO-1250342", "R-MMU-9028731", "R-RNO-447043", "R-CFA-6788467", "R-RNO-1227986", "R-HSA-376176", "R-MMU-1169091", "R-HSA-5690714", "R-DME-1474228", "R-SSC-202424", "R-DME-8941413", "R-MMU-8851680", "R-HSA-9669914", "R-GGA-1250347", "R-HSA-5654219", "R-CEL-5654689", "R-HSA-187024", "R-MMU-5654689", "R-HSA-9674428", "R-GGA-433692", "R-GGA-1236394", "R-CEL-186797", "R-DME-5654706", "R-SSC-198933", "R-GGA-1250342", "R-CEL-433692", "R-HSA-5654688", "R-CEL-373753", "R-MMU-6785631", "R-MMU-163125", "R-CFA-202430", "R-RNO-5654726", "R-MMU-5607764", "R-MMU-9020933", "R-RNO-9014843", "R-HSA-9927418", "R-MMU-2243919", "R-HSA-4420097", "R-RNO-190373", "R-RNO-202733", "R-CEL-1433559", "R-CEL-190370", "R-SSC-202433", "R-RNO-202424", "R-DRE-5654733", "R-HSA-177929", "R-HSA-202430", "R-GGA-193634", "R-HSA-5655302", "R-MMU-193634", "R-DRE-5654720", "R-RNO-5654693", "R-DME-1227986", "R-HSA-9665686", "R-DRE-9007892", "R-HSA-8853334", "R-RNO-198933", "R-HSA-8847993", "R-MMU-8849932", "R-RNO-5658623", "R-MMU-5654700", "R-HSA-2033515", "R-DRE-190373", "R-CFA-389948", "R-RNO-420029", "R-DME-388844", "R-MMU-195399", "R-DRE-5654710", "R-HSA-9013149", "R-DME-5654710", "R-BTA-389948", "R-HSA-8980692", "R-HSA-1169091", "R-HSA-5654720", "R-HSA-4420332", "R-RNO-445989", "R-HSA-418890", "R-HSA-198933", "R-MMU-376172", "R-MMU-5654688", "R-RNO-433692", "R-DRE-416482", "R-HSA-5654704", "R-RNO-9028731", "R-MMU-375165", "R-HSA-8853884"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-190322:r:FGFR4 ligand binding and activation", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8951664:r:Neddylation", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-9014843:r:Interleukin-33 signaling", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DME-3000178:r:ECM proteoglycans", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-RNO-416476:r:G alpha (q) signalling events", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-186763:r:Downstream signal transduction", "R-HSA-373752:r:Netrin-1 signaling", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-DRE-109704:r:PI3K Cascade", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-GGA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-HSA-114608:r:Platelet degranulation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9020591:r:Interleukin-12 signaling", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-1566977:r:Fibronectin matrix formation", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-DME-6798695:r:Neutrophil degranulation", "R-XTR-418990:r:Adherens junctions interactions", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-CEL-9749641:r:Aspirin ADME", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9014843:r:Interleukin-33 signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-SSC-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-193648:r:NRAGE signals death through JNK", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-975634:r:Retinoid metabolism and transport", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-186797:r:Signaling by PDGF", "R-RNO-9020702:r:Interleukin-1 signaling", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-CFA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-MMU-432142:r:Platelet sensitization by LDL", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-418990:r:Adherens junctions interactions", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-GGA-373920:r:Pyruvate metabolism", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-2172127:r:DAP12 interactions", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-373753:r:Nephrin family interactions", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-BTA-445355:r:Smooth Muscle Contraction", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-SSC-216083:r:Integrin cell surface interactions", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DRE-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-CEL-419037:r:NCAM1 interactions", "R-CEL-209968:r:Thyroxine biosynthesis", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-373760:r:L1CAM interactions", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-114608:r:Platelet degranulation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-HSA-2024096:r:HS-GAG degradation", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-DME-2024096:r:HS-GAG degradation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-HSA-9020591:r:Interleukin-12 signaling", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-390522:r:Striated Muscle Contraction", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-445144:r:Signal transduction by L1", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-186763:r:Downstream signal transduction", "R-DME-447043:r:Neurofascin interactions", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-1236394:r:Signaling by ERBB4", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-390522:r:Striated Muscle Contraction", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9020702:r:Interleukin-1 signaling", "R-GGA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-202433:r:Generation of second messenger molecules", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-RNO-525793:r:Myogenesis", "R-GGA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210990:r:PECAM1 interactions", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-447038:r:NrCAM interactions", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-77387:r:Insulin receptor recycling", "R-MMU-9007892:r:Interleukin-38 signaling", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-RNO-2029481:r:FCGR activation", "R-SSC-432142:r:Platelet sensitization by LDL", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-447043:r:Neurofascin interactions", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-420029:r:Tight junction interactions", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-433692:r:Proton-coupled monocarboxylate transport", "R-RNO-8951664:r:Neddylation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-SSC-389948:r:Co-inhibition by PD-1", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-77387:r:Insulin receptor recycling", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-2172127:r:DAP12 interactions", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DME-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-GGA-210991:r:Basigin interactions", "R-MMU-447043:r:Neurofascin interactions", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-419037:r:NCAM1 interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-373760:r:L1CAM interactions", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-CFA-202433:r:Generation of second messenger molecules", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-432142:r:Platelet sensitization by LDL", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DME-9749641:r:Aspirin ADME", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-CEL-190322:r:FGFR4 ligand binding and activation", "R-DRE-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-420029:r:Tight junction interactions", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-DME-1236394:r:Signaling by ERBB4", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-1433559:r:Regulation of KIT signaling", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-RNO-420597:r:Nectin/Necl trans heterodimerization", "R-SSC-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-3000157:r:Laminin interactions", "R-SSC-114608:r:Platelet degranulation", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-416700:r:Other semaphorin interactions", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-418885:r:DCC mediated attractive signaling", "R-CFA-1433559:r:Regulation of KIT signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-5619070:r:Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-202433:r:Generation of second messenger molecules", "R-RNO-210991:r:Basigin interactions", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-1566977:r:Fibronectin matrix formation", "R-DME-77387:r:Insulin receptor recycling", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-9830674:r:Formation of the ureteric bud", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-DME-2022928:r:HS-GAG biosynthesis", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416476:r:G alpha (q) signalling events", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-RNO-186763:r:Downstream signal transduction", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-77387:r:Insulin receptor recycling", "R-BTA-5690714:r:CD22 mediated BCR regulation", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9620244:r:Long-term potentiation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5683826:r:Surfactant metabolism", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-376172:r:DSCAM interactions", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-419037:r:NCAM1 interactions", "R-HSA-9669933:r:Signaling by kinase domain mutants of KIT", "R-DRE-190370:r:FGFR1b ligand binding and activation", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-RNO-418990:r:Adherens junctions interactions", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-977443:r:GABA receptor activation", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-BTA-114608:r:Platelet degranulation", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9014826:r:Interleukin-36 pathway", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-373752:r:Netrin-1 signaling", "R-HSA-420597:r:Nectin/Necl trans heterodimerization", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-CFA-202424:r:Downstream TCR signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-376172:r:DSCAM interactions", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-4086400:r:PCP/CE pathway", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-GGA-1433559:r:Regulation of KIT signaling", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-9749641:r:Aspirin ADME", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-420029:r:Tight junction interactions", "R-DRE-202733:r:Cell surface interactions at the vascular wall", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-418990:r:Adherens junctions interactions", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-5632681:r:Ligand-receptor interactions", "R-SSC-210990:r:PECAM1 interactions", "R-DRE-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-1236394:r:Signaling by ERBB4", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-210991:r:Basigin interactions", "R-CEL-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-210991:r:Basigin interactions", "R-DME-109704:r:PI3K Cascade", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-437239:r:Recycling pathway of L1", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DRE-216083:r:Integrin cell surface interactions", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-416700:r:Other semaphorin interactions", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-216083:r:Integrin cell surface interactions", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-2024096:r:HS-GAG degradation", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-2029481:r:FCGR activation", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-209968:r:Thyroxine biosynthesis", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-HSA-428540:r:Activation of RAC1", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-SSC-9020591:r:Interleukin-12 signaling", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-373756:r:SDK interactions", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-2029481:r:FCGR activation", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9007892:r:Interleukin-38 signaling", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-CEL-525793:r:Myogenesis", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5635838:r:Activation of SMO", "R-RNO-9014826:r:Interleukin-36 pathway", "R-GGA-216083:r:Integrin cell surface interactions", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9020933:r:Interleukin-23 signaling", "R-SSC-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-5635838:r:Activation of SMO", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-RNO-376172:r:DSCAM interactions", "R-MMU-416700:r:Other semaphorin interactions", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-GGA-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-MMU-114608:r:Platelet degranulation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-RNO-432142:r:Platelet sensitization by LDL", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-419037:r:NCAM1 interactions", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-109704:r:PI3K Cascade", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-210990:r:PECAM1 interactions", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-449836:r:Other interleukin signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-525793:r:Myogenesis", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-MMU-389948:r:Co-inhibition by PD-1", "R-BTA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-CEL-210991:r:Basigin interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-373756:r:SDK interactions", "R-HSA-1462054:r:Alpha-defensins", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-186797:r:Signaling by PDGF", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-9007892:r:Interleukin-38 signaling", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-449836:r:Other interleukin signaling", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-MMU-210991:r:Basigin interactions", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-RNO-373753:r:Nephrin family interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-MMU-5632681:r:Ligand-receptor interactions", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-RNO-1566977:r:Fibronectin matrix formation", "R-RNO-445144:r:Signal transduction by L1", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-447041:r:CHL1 interactions", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-GGA-9749641:r:Aspirin ADME", "R-BTA-202433:r:Generation of second messenger molecules", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-DME-373752:r:Netrin-1 signaling", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-XTR-202433:r:Generation of second messenger molecules", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-373752:r:Netrin-1 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-9674404:r:Sorafenib-resistant PDGFR mutants", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-202424:r:Downstream TCR signaling", "R-GGA-1250196:r:SHC1 events in ERBB2 signaling", "R-SSC-2029481:r:FCGR activation", "R-MMU-437239:r:Recycling pathway of L1", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-109704:r:PI3K Cascade", "R-DRE-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-RNO-447043:r:Neurofascin interactions", "R-CFA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-376176:r:Signaling by ROBO receptors", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-SSC-202424:r:Downstream TCR signaling", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-HSA-187024:r:NGF-independant TRKA activation", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-GGA-433692:r:Proton-coupled monocarboxylate transport", "R-GGA-1236394:r:Signaling by ERBB4", "R-CEL-186797:r:Signaling by PDGF", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-SSC-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-GGA-1250342:r:PI3K events in ERBB4 signaling", "R-CEL-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-373753:r:Nephrin family interactions", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-CFA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9020933:r:Interleukin-23 signaling", "R-RNO-9014843:r:Interleukin-33 signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-190370:r:FGFR1b ligand binding and activation", "R-SSC-202433:r:Generation of second messenger molecules", "R-RNO-202424:r:Downstream TCR signaling", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-GGA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DRE-9007892:r:Interleukin-38 signaling", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", "R-DRE-190373:r:FGFR1c ligand binding and activation", "R-CFA-389948:r:Co-inhibition by PD-1", "R-RNO-420029:r:Tight junction interactions", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DRE-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-376172:r:DSCAM interactions", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-433692:r:Proton-coupled monocarboxylate transport", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8853884:r:Transcriptional Regulation by VENTX"], "type": "Domain"}, "IPR003599": {"description": "Immunoglobulin domain subtype", "go_ids": [], "go_terms": [], "name": "Ig_sub", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-RNO-2022923", "R-RNO-190322", "R-DRE-5654699", "R-MMU-5654720", "R-HSA-8951664", "R-HSA-77387", "R-HSA-2871796", "R-HSA-9669936", "R-HSA-9010553", "R-MMU-9014843", "R-HSA-9010642", "R-DRE-190372", "R-CEL-5654219", "R-RNO-2871809", "R-MMU-5654221", "R-DME-3000178", "R-MMU-933542", "R-HSA-5654695", "R-MMU-202733", "R-DRE-5654228", "R-RNO-177504", "R-RNO-375165", "R-RNO-416476", "R-BTA-163125", "R-DME-5654727", "R-GGA-5673001", "R-HSA-2022870", "R-RNO-190374", "R-HSA-3000171", "R-DRE-186763", "R-HSA-373752", "R-CEL-5654726", "R-HSA-190377", "R-HSA-3656244", "R-HSA-389356", "R-HSA-5654700", "R-CEL-1433557", "R-HSA-399954", 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"R-MMU-8985586", "R-MMU-983695", "R-MMU-2454202", "R-HSA-1433557", "R-HSA-9032500", "R-GGA-1433559", "R-CEL-190372", "R-DME-8849932", "R-HSA-8985586", "R-HSA-428543", "R-HSA-9929356", "R-MMU-2871809", "R-CEL-1971475", "R-MMU-9013026", "R-DME-3000171", "R-RNO-9749641", "R-BTA-2022923", "R-RNO-1250196", "R-DME-5654726", "R-DRE-5654719", "R-MMU-9026527", "R-MMU-1250342", "R-MMU-8856828", "R-HSA-879415", "R-RNO-1250347", "R-GGA-1963642", "R-HSA-9669921", "R-RNO-9013409", "R-MMU-6811558", "R-MMU-433692", "R-HSA-420029", "R-DRE-202733", "R-RNO-187042", "R-HSA-1306955", "R-MMU-418889", "R-DRE-388844", "R-MMU-202430", "R-RNO-399954", "R-HSA-418990", "R-CEL-9607240", "R-HSA-8863795", "R-HSA-5632681", "R-SSC-210990", "R-DRE-198933", "R-MMU-1236394", "R-RNO-193648", "R-MMU-186763", "R-HSA-210991", "R-HSA-9931295", "R-CEL-428542", "R-MMU-9035034", "R-SSC-2022854", "R-HSA-983695", "R-DME-210991", "R-DME-109704", "R-MMU-399955", "R-HSA-437239", "R-RNO-9013148", "R-HSA-9927353", "R-DME-190377", "R-MMU-5140745", "R-DRE-216083", "R-HSA-419037", "R-RNO-2022857", "R-HSA-163125", "R-DME-216083", "R-HSA-9820960", "R-HSA-9008059", "R-DME-416572", "R-MMU-5654219", "R-HSA-3656225", "R-RNO-2730905", "R-MMU-1963642", "R-MMU-216083", "R-HSA-180534", "R-RNO-388844", "R-HSA-389357", "R-DME-416700", "R-MMU-5654712", "R-CEL-6811558", "R-RNO-5654712", "R-HSA-9680350", "R-MMU-5654227", "R-RNO-2172127", "R-RNO-216083", "R-DME-1971475", "R-GGA-1474228", "R-HSA-1251985", "R-RNO-8980692", "R-RNO-1257604", "R-CEL-5654720", "R-DRE-9013404", "R-HSA-8849932", "R-CEL-2024096", "R-DRE-5654221", "R-MMU-173623", "R-RNO-5654719", "R-RNO-416482", "R-CEL-5654712", "R-MMU-2132295", "R-RNO-3928662", "R-RNO-6788467", "R-GGA-1433557", "R-CFA-1433557", "R-RNO-2022870", "R-HSA-190372", "R-MMU-5660668", "R-HSA-5655332", "R-DME-5654719", "R-HSA-109704", "R-MMU-1227986", "R-HSA-2871809", "R-HSA-6785631", "R-HSA-9034864", "R-HSA-190371", "R-MMU-1257604", "R-BTA-8849932", "R-RNO-5632681", "R-HSA-1358803", "R-HSA-110056", "R-HSA-9669934", "R-MMU-190371", "R-HSA-6807004", "R-HSA-8853336", "R-MMU-2029481", "R-MMU-389513", "R-DRE-190374", "R-DME-209968", "R-HSA-5173214", "R-RNO-9032759", "R-HSA-8856825", "R-MMU-5654727", "R-CEL-8941413", "R-HSA-9680187", "R-HSA-428540", "R-RNO-2022854", "R-HSA-9856649", "R-DRE-4420097", "R-BTA-216083", "R-HSA-8853333", "R-HSA-391160", "R-MMU-1963640", "R-HSA-3595174", "R-CFA-9856649", "R-MMU-1433559", "R-CEL-2022928", "R-MMU-9013106", "R-HSA-8856828", "R-MMU-9012546", "R-HSA-5654228", "R-MMU-373756", "R-GGA-1227986", "R-HSA-2029481", "R-HSA-9026519", "R-CEL-5673001", "R-DRE-5673001", "R-CFA-1257604", "R-BTA-5576892", "R-MMU-389357", "R-MMU-5654695", "R-MMU-9706374", "R-CEL-5654732", "R-MMU-381426", "R-MMU-399954", "R-RNO-170968", "R-BTA-2022870", "R-CEL-5654228", "R-HSA-9673767", "R-RNO-9013408", "R-HSA-2023837", "R-HSA-9007892", "R-RNO-5673001", "R-MMU-2168880", "R-RNO-3000178", "R-MMU-2022923", "R-DME-5654227", "R-CEL-525793", "R-HSA-373753", "R-HSA-9927354", "R-HSA-447043", "R-HSA-2404192", "R-MMU-1433557", "R-BTA-198933", "R-DME-5654704", "R-MMU-5635838", "R-RNO-9014826", "R-GGA-216083", "R-HSA-9034793", "R-HSA-451927"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-RNO-190322:r:FGFR4 ligand binding and activation", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8951664:r:Neddylation", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-9014843:r:Interleukin-33 signaling", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DME-3000178:r:ECM proteoglycans", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-RNO-416476:r:G alpha (q) signalling events", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-186763:r:Downstream signal transduction", "R-HSA-373752:r:Netrin-1 signaling", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-389356:r:Co-stimulation by CD28", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-GGA-3000178:r:ECM proteoglycans", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-DRE-109704:r:PI3K Cascade", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-GGA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-HSA-114608:r:Platelet degranulation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-XTR-418990:r:Adherens junctions interactions", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-CEL-9749641:r:Aspirin ADME", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-9014843:r:Interleukin-33 signaling", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-DRE-193648:r:NRAGE signals death through JNK", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-975634:r:Retinoid metabolism and transport", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-RNO-9020702:r:Interleukin-1 signaling", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-418990:r:Adherens junctions interactions", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-GGA-373920:r:Pyruvate metabolism", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-2172127:r:DAP12 interactions", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-373753:r:Nephrin family interactions", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-1462054:r:Alpha-defensins", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-BTA-445355:r:Smooth Muscle Contraction", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-SSC-216083:r:Integrin cell surface interactions", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-HSA-9012546:r:Interleukin-18 signaling", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DRE-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-CEL-419037:r:NCAM1 interactions", "R-CEL-209968:r:Thyroxine biosynthesis", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-5635838:r:Activation of SMO", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-RNO-376172:r:DSCAM interactions", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-MMU-416700:r:Other semaphorin interactions", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-GGA-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-MMU-114608:r:Platelet degranulation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-RNO-432142:r:Platelet sensitization by LDL", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-DME-419037:r:NCAM1 interactions", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-BTA-3000178:r:ECM proteoglycans", "R-RNO-109704:r:PI3K Cascade", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DRE-449836:r:Other interleukin signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-525793:r:Myogenesis", "R-BTA-2024101:r:CS/DS degradation", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-389948:r:Co-inhibition by PD-1", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-CEL-210991:r:Basigin interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-373756:r:SDK interactions", "R-HSA-1462054:r:Alpha-defensins", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-186797:r:Signaling by PDGF", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DRE-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-9007892:r:Interleukin-38 signaling", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-449836:r:Other interleukin signaling", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-MMU-210991:r:Basigin interactions", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-RNO-373753:r:Nephrin family interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-MMU-5632681:r:Ligand-receptor interactions", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-182971:r:EGFR downregulation", "R-RNO-1566977:r:Fibronectin matrix formation", "R-RNO-445144:r:Signal transduction by L1", "R-SSC-2022857:r:Keratan sulfate degradation", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CFA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-447041:r:CHL1 interactions", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-GGA-9749641:r:Aspirin ADME", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-DME-373752:r:Netrin-1 signaling", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-XTR-202433:r:Generation of second messenger molecules", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-373752:r:Netrin-1 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-9674404:r:Sorafenib-resistant PDGFR mutants", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-202424:r:Downstream TCR signaling", "R-GGA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-MMU-437239:r:Recycling pathway of L1", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-977606:r:Regulation of Complement cascade", "R-MMU-109704:r:PI3K Cascade", "R-DRE-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-RNO-447043:r:Neurofascin interactions", "R-CFA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-HSA-376176:r:Signaling by ROBO receptors", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-HSA-187024:r:NGF-independant TRKA activation", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-GGA-433692:r:Proton-coupled monocarboxylate transport", "R-GGA-1236394:r:Signaling by ERBB4", "R-CEL-186797:r:Signaling by PDGF", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-8964038:r:LDL clearance", "R-GGA-1250342:r:PI3K events in ERBB4 signaling", "R-CEL-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-CEL-373753:r:Nephrin family interactions", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-9014843:r:Interleukin-33 signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-RNO-9927353:r:Co-inhibition by BTLA", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-190370:r:FGFR1b ligand binding and activation", "R-RNO-202424:r:Downstream TCR signaling", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-177929:r:Signaling by EGFR", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-GGA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-373760:r:L1CAM interactions", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-CFA-216083:r:Integrin cell surface interactions", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8964046:r:VLDL clearance", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-114608:r:Platelet degranulation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-2024101:r:CS/DS degradation", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-HSA-2024096:r:HS-GAG degradation", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-DME-2024096:r:HS-GAG degradation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-390522:r:Striated Muscle Contraction", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-CEL-445144:r:Signal transduction by L1", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-186763:r:Downstream signal transduction", "R-DME-447043:r:Neurofascin interactions", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-1236394:r:Signaling by ERBB4", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-GGA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-202433:r:Generation of second messenger molecules", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-RNO-525793:r:Myogenesis", "R-GGA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-447038:r:NrCAM interactions", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-77387:r:Insulin receptor recycling", "R-MMU-9007892:r:Interleukin-38 signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-RNO-2029481:r:FCGR activation", "R-SSC-432142:r:Platelet sensitization by LDL", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-CEL-447043:r:Neurofascin interactions", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-420029:r:Tight junction interactions", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-433692:r:Proton-coupled monocarboxylate transport", "R-RNO-8951664:r:Neddylation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-77387:r:Insulin receptor recycling", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-MMU-2172127:r:DAP12 interactions", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DME-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-GGA-210991:r:Basigin interactions", "R-MMU-447043:r:Neurofascin interactions", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-419037:r:NCAM1 interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-373760:r:L1CAM interactions", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-182971:r:EGFR downregulation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-432142:r:Platelet sensitization by LDL", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DME-9749641:r:Aspirin ADME", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-CEL-190322:r:FGFR4 ligand binding and activation", "R-DRE-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-420029:r:Tight junction interactions", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-1433559:r:Regulation of KIT signaling", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-BTA-5690714:r:CD22 mediated BCR regulation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-RNO-77387:r:Insulin receptor recycling", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-445144:r:Signal transduction by L1", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9620244:r:Long-term potentiation", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-376172:r:DSCAM interactions", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-419037:r:NCAM1 interactions", "R-HSA-9669933:r:Signaling by kinase domain mutants of KIT", "R-DRE-190370:r:FGFR1b ligand binding and activation", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-SSC-3000178:r:ECM proteoglycans", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-HSA-2024101:r:CS/DS degradation", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DRE-9007892:r:Interleukin-38 signaling", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", "R-GGA-2132286:r:Classical antibody-mediated complement activation", "R-DRE-190373:r:FGFR1c ligand binding and activation", "R-RNO-420029:r:Tight junction interactions", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DRE-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9014826:r:Interleukin-36 pathway", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-376172:r:DSCAM interactions", "R-MMU-1462054:r:Alpha-defensins", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-433692:r:Proton-coupled monocarboxylate transport", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-RNO-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-3000157:r:Laminin interactions", "R-SSC-114608:r:Platelet degranulation", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-416700:r:Other semaphorin interactions", "R-HSA-416476:r:G alpha (q) signalling events", "R-CFA-5690714:r:CD22 mediated BCR regulation", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-418885:r:DCC mediated attractive signaling", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-CFA-1433559:r:Regulation of KIT signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-5619070:r:Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-202433:r:Generation of second messenger molecules", "R-RNO-210991:r:Basigin interactions", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-1566977:r:Fibronectin matrix formation", "R-DME-77387:r:Insulin receptor recycling", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-9830674:r:Formation of the ureteric bud", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-DME-2022928:r:HS-GAG biosynthesis", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416476:r:G alpha (q) signalling events", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-186763:r:Downstream signal transduction", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-RNO-418990:r:Adherens junctions interactions", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-977443:r:GABA receptor activation", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-BTA-114608:r:Platelet degranulation", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9014826:r:Interleukin-36 pathway", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-373752:r:Netrin-1 signaling", "R-HSA-420597:r:Nectin/Necl trans heterodimerization", "R-RNO-170984:r:ARMS-mediated activation", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-376172:r:DSCAM interactions", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-4086400:r:PCP/CE pathway", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-GGA-1433559:r:Regulation of KIT signaling", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-9749641:r:Aspirin ADME", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-420029:r:Tight junction interactions", "R-DRE-202733:r:Cell surface interactions at the vascular wall", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-418990:r:Adherens junctions interactions", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-5632681:r:Ligand-receptor interactions", "R-SSC-210990:r:PECAM1 interactions", "R-DRE-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-1236394:r:Signaling by ERBB4", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-210991:r:Basigin interactions", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CEL-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-9035034:r:RHOF GTPase cycle", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-210991:r:Basigin interactions", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-437239:r:Recycling pathway of L1", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DRE-216083:r:Integrin cell surface interactions", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-9008059:r:Interleukin-37 signaling", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-416700:r:Other semaphorin interactions", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-2172127:r:DAP12 interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-2024096:r:HS-GAG degradation", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-209968:r:Thyroxine biosynthesis", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-HSA-428540:r:Activation of RAC1", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9012546:r:Interleukin-18 signaling", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-373756:r:SDK interactions", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-2029481:r:FCGR activation", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-170968:r:Frs2-mediated activation", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-HSA-9007892:r:Interleukin-38 signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-CEL-525793:r:Myogenesis", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-5635838:r:Activation of SMO", "R-RNO-9014826:r:Interleukin-36 pathway", "R-GGA-216083:r:Integrin cell surface interactions", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-451927:r:Interleukin-2 family signaling"], "type": "Domain"}, "IPR003601": {"description": "DNA topoisomerase, type IA, domain 2", "go_ids": ["GO:0003677", "GO:0003916", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003916:DNA topoisomerase activity:F", "GO:0006265:DNA topological change:P"], "name": "Topo_IA_2", "pathway_ids": ["R-DDI-5693616", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-DDI-5693607", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR003602": {"description": "DNA topoisomerase, type IA, DNA-binding domain", "go_ids": ["GO:0003677", "GO:0003916", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003916:DNA topoisomerase activity:F", "GO:0006265:DNA topological change:P"], "name": "Topo_IA_DNA-bd_dom", "pathway_ids": ["R-DDI-5693616", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-DDI-5693607", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR003603": {"description": "U2A'/phosphoprotein 32 family A, C-terminal", "go_ids": [], "go_terms": [], "name": "U2A'_phosphoprotein32A_C", "pathway_ids": ["R-BTA-450520", "R-MMU-380259", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-DRE-450520", "R-HSA-8950505", "R-HSA-450520", "R-MMU-380270", "R-HSA-380284", "R-HSA-380270", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942", "R-HSA-380320", "R-HSA-72163", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-HSA-9918481"], "pathways": ["R-BTA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DRE-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR003604": {"description": "Matrin/U1-C-like, C2H2-type zinc finger", "go_ids": ["GO:0003676", "GO:0008270"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0008270:zinc ion binding:F"], "name": "Matrin/U1-like-C_Znf_C2H2", "pathway_ids": ["R-RNO-6781823", "R-HSA-9819196", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-9770562", "R-MMU-69895", "R-RNO-72163", "R-DDI-9770562", "R-XTR-72163", "R-HSA-6787450", "R-HSA-6781823", "R-HSA-6804759", "R-DME-9770562", "R-HSA-9820865", "R-MMU-6781823", "R-CFA-9770562", "R-DRE-9770562", "R-HSA-6782315", "R-CEL-9770562", "R-HSA-8941855", "R-HSA-6782210", "R-CEL-8941855", "R-CEL-72163", "R-MMU-6804759", "R-HSA-9918481", "R-MMU-8941855", "R-RNO-6782210", "R-BTA-72163", "R-HSA-9770562", "R-HSA-429947", "R-RNO-6782135", "R-MMU-72163", "R-HSA-381340", "R-HSA-6782135", "R-HSA-69895", "R-SPO-9770562", "R-HSA-72163", "R-XTR-6782210", "R-HSA-6804114", "R-RNO-9770562", "R-XTR-6782135", "R-BTA-9770562", "R-MMU-6782210", "R-XTR-6781823", "R-HSA-6804116"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-9770562:r:mRNA Polyadenylation", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6787450:r:tRNA modification in the mitochondrion", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CFA-9770562:r:mRNA Polyadenylation", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8941855:r:RUNX3 regulates CDKN1A transcription", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-429947:r:Deadenylation of mRNA", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-XTR-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-9770562:r:mRNA Polyadenylation", "R-XTR-6782135:r:Dual incision in TC-NER", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "type": "Domain"}, "IPR003605": {"description": "GS domain", "go_ids": ["GO:0004675", "GO:0005524", "GO:0006468", "GO:0016020"], "go_terms": ["GO:0004675:transmembrane receptor protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P", "GO:0016020:membrane:C"], "name": "GS_dom", "pathway_ids": ["R-DME-2173789", "R-DME-1502540", "R-BTA-5689880", "R-HSA-3656535", "R-DME-2173788", "R-HSA-5689880", "R-MMU-2173791", "R-HSA-201451", "R-RNO-2173788", "R-BTA-2173789", "R-HSA-3656532", "R-MMU-5689880", "R-HSA-9839389", "R-BTA-9839389", "R-HSA-1181150", "R-MMU-201451", "R-RNO-201451", "R-RNO-9839389", "R-RNO-2173789", "R-HSA-2173789", "R-MMU-1502540", "R-HSA-3645790", "R-CEL-2173788", "R-MMU-2173789", "R-MMU-9839389", "R-HSA-2173791", "R-BTA-2173791", "R-HSA-3304356", "R-HSA-1502540", "R-BTA-2173788", "R-DME-2173791", "R-RNO-5689880", "R-RNO-2173791", "R-DME-9839389", "R-RNO-1502540", "R-HSA-5689603", "R-MMU-2173788", "R-CEL-2173789", "R-HSA-2173788", "R-HSA-1433617", "R-DME-5689880"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-1502540:r:Signaling by Activin", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-201451:r:Signaling by BMP", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-1181150:r:Signaling by NODAL", "R-MMU-201451:r:Signaling by BMP", "R-RNO-201451:r:Signaling by BMP", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-1502540:r:Signaling by Activin", "R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-HSA-1502540:r:Signaling by Activin", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-1502540:r:Signaling by Activin", "R-HSA-5689603:r:UCH proteinases", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-DME-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR003607": {"description": "HD/PDEase domain", "go_ids": [], "go_terms": [], "name": "HD/PDEase_dom", "pathway_ids": ["R-HSA-9013422", "R-RNO-9013422", "R-MMU-4086398", "R-HSA-2485179", "R-MMU-165160", "R-MMU-445355", "R-DME-445355", "R-CEL-418555", "R-HSA-418457", "R-MMU-9013422", "R-DME-418457", "R-CFA-4086398", "R-DDI-418555", "R-GGA-8956319", "R-DDI-165160", "R-DDI-2485179", "R-CEL-9860927", "R-HSA-2514859", "R-DDI-8956319", "R-HSA-418555", "R-BTA-111957", "R-RNO-180024", "R-PFA-418555", "R-CFA-418457", "R-BTA-8956319", "R-BTA-445355", "R-CEL-180024", "R-CFA-9013422", "R-BTA-418555", "R-HSA-909733", "R-RNO-111957", "R-HSA-165160", "R-SCE-418555", "R-PFA-165160", "R-RNO-2514859", "R-PFA-418457", "R-CEL-165160", "R-DDI-418457", "R-RNO-418555", "R-CEL-111957", "R-DME-418555", "R-SCE-165160", "R-RNO-165160", "R-DME-9860927", "R-MMU-418457", "R-MMU-111957", "R-DDI-9013422", "R-RNO-445355", "R-MMU-180024", "R-DDI-111957", "R-MMU-2514859", "R-RNO-418457", "R-HSA-4086398", "R-CFA-2485179", "R-HSA-180024", "R-DME-111957", "R-HSA-445355", "R-CEL-418457", "R-DRE-8956319", "R-RNO-2485179", "R-PFA-445355", "R-CFA-445355", "R-DME-180024", "R-DME-9013422", "R-BTA-418457", "R-BTA-9013422", "R-RNO-4086398", "R-HSA-8956319", "R-DDI-445355", "R-DDI-4086398", "R-MMU-2485179", "R-HSA-111957", "R-CEL-8956319", "R-MMU-418555", "R-MMU-8956319"], "pathways": ["R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-MMU-165160:r:PDE3B signalling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-CEL-418555:r:G alpha (s) signalling events", "R-HSA-418457:r:cGMP effects", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DME-418457:r:cGMP effects", "R-CFA-4086398:r:Ca2+ pathway", "R-DDI-418555:r:G alpha (s) signalling events", "R-GGA-8956319:r:Nucleotide catabolism", "R-DDI-165160:r:PDE3B signalling", "R-DDI-2485179:r:Activation of the phototransduction cascade", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-8956319:r:Nucleotide catabolism", "R-HSA-418555:r:G alpha (s) signalling events", "R-BTA-111957:r:Cam-PDE 1 activation", "R-RNO-180024:r:DARPP-32 events", "R-PFA-418555:r:G alpha (s) signalling events", "R-CFA-418457:r:cGMP effects", "R-BTA-8956319:r:Nucleotide catabolism", "R-BTA-445355:r:Smooth Muscle Contraction", "R-CEL-180024:r:DARPP-32 events", "R-CFA-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-418555:r:G alpha (s) signalling events", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-111957:r:Cam-PDE 1 activation", "R-HSA-165160:r:PDE3B signalling", "R-SCE-418555:r:G alpha (s) signalling events", "R-PFA-165160:r:PDE3B signalling", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-PFA-418457:r:cGMP effects", "R-CEL-165160:r:PDE3B signalling", "R-DDI-418457:r:cGMP effects", "R-RNO-418555:r:G alpha (s) signalling events", "R-CEL-111957:r:Cam-PDE 1 activation", "R-DME-418555:r:G alpha (s) signalling events", "R-SCE-165160:r:PDE3B signalling", "R-RNO-165160:r:PDE3B signalling", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-418457:r:cGMP effects", "R-MMU-111957:r:Cam-PDE 1 activation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-445355:r:Smooth Muscle Contraction", 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"R-HSA-111957:r:Cam-PDE 1 activation", "R-CEL-8956319:r:Nucleotide catabolism", "R-MMU-418555:r:G alpha (s) signalling events", "R-MMU-8956319:r:Nucleotide catabolism"], "type": "Domain"}, "IPR003609": {"description": "PAN/Apple domain", "go_ids": [], "go_terms": [], "name": "Pan_app", "pathway_ids": ["R-HSA-186797", "R-HSA-8874081", "R-HSA-8875555", "R-BTA-140837", "R-MMU-6811558", "R-HSA-140837", "R-MMU-8875791", "R-CFA-9734091", "R-MMU-8865999", "R-CFA-114608", "R-HSA-6806942", "R-RNO-140837", "R-CFA-1257604", "R-CFA-8851805", "R-RNO-6811558", "R-MMU-8851805", "R-CFA-6807004", "R-CFA-5673001", "R-HSA-8875513", "R-CFA-186797", "R-CFA-8851907", "R-RNO-5673001", "R-HSA-75205", "R-HSA-1266695", "R-HSA-381426", "R-RNO-8865999", "R-MMU-5673001", "R-RNO-6806942", "R-HSA-1474228", "R-MMU-1592389", "R-CFA-8874081", "R-CFA-8875513", "R-MMU-140837", "R-HSA-2219530", "R-HSA-6785807", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-381426", "R-MMU-8875555", "R-CFA-8875555", "R-RNO-8875656", 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"R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CEL-8941326:r:RUNX2 regulates bone development", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-8941326:r:RUNX2 regulates bone development", "R-CEL-201451:r:Signaling by BMP", "R-GGA-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-RNO-1181150:r:Signaling by NODAL", "R-HSA-877300:r:Interferon gamma signaling", "R-DME-1181150:r:Signaling by NODAL", "R-HSA-9733709:r:Cardiogenesis", "R-DRE-1502540:r:Signaling by Activin", "R-DME-8941326:r:RUNX2 regulates bone development", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-SSC-8941326:r:RUNX2 regulates bone development"], "type": "Domain"}, "IPR003620": {"description": "Urocortin/corticotropin-releasing factor", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Urocortin_CRF", "pathway_ids": ["R-HSA-9022702", "R-HSA-373080", "R-BTA-373080", "R-BTA-418555", "R-SSC-373080", "R-MMU-418555", "R-HSA-418555", "R-RNO-373080", "R-MMU-373080", "R-HSA-422085"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-BTA-373080:r:Class B/2 (Secretin family receptors)", "R-BTA-418555:r:G alpha (s) signalling events", "R-SSC-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin"], "type": "Family"}, "IPR003624": {"description": "Leukemia inhibitory factor", "go_ids": ["GO:0005146", "GO:0005576"], "go_terms": ["GO:0005146:leukemia inhibitory factor receptor binding:F", "GO:0005576:extracellular region:C"], "name": "Leukemia_IF", "pathway_ids": ["R-MMU-6788467", "R-RNO-6788467", "R-BTA-6788467", "R-HSA-6788467", "R-HSA-6785807", "R-HSA-6783783"], "pathways": ["R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-BTA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6783783:r:Interleukin-10 signaling"], "type": "Family"}, "IPR003625": {"description": "Parathyroid hormone", "go_ids": ["GO:0005179", "GO:0005576", "GO:0006874"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C", "GO:0006874:intracellular calcium ion homeostasis:P"], "name": "PTH", "pathway_ids": ["R-HSA-373080", "R-GGA-418555", "R-CFA-373080", "R-BTA-373080", "R-BTA-418555", "R-SSC-373080", "R-GGA-373080", "R-HSA-418555", "R-RNO-373080", "R-MMU-373080", "R-MMU-418555"], "pathways": ["R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-GGA-418555:r:G alpha (s) signalling events", "R-CFA-373080:r:Class B/2 (Secretin family receptors)", "R-BTA-373080:r:Class B/2 (Secretin family receptors)", "R-BTA-418555:r:G alpha (s) signalling events", "R-SSC-373080:r:Class B/2 (Secretin family receptors)", "R-GGA-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Family"}, "IPR003626": {"description": "Parathyroid hormone-related protein", "go_ids": ["GO:0005179", "GO:0005576", "GO:0030282"], "go_terms": ["GO:0005179:hormone 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"name": "Neurokinin-B/TAC3", "pathway_ids": ["R-MMU-416476", "R-HSA-380095", "R-SSC-380095", "R-BTA-380095", "R-MMU-380095", "R-HSA-416476", "R-RNO-416476", "R-RNO-380095", "R-SSC-416476", "R-BTA-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-380095:r:Tachykinin receptors bind tachykinins", "R-SSC-380095:r:Tachykinin receptors bind tachykinins", "R-BTA-380095:r:Tachykinin receptors bind tachykinins", "R-MMU-380095:r:Tachykinin receptors bind tachykinins", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-380095:r:Tachykinin receptors bind tachykinins", "R-SSC-416476:r:G alpha (q) signalling events", "R-BTA-416476:r:G alpha (q) signalling events"], "type": "Family"}, "IPR003644": {"description": "Na-Ca exchanger/integrin-beta4", "go_ids": ["GO:0007154", "GO:0016020"], "go_terms": ["GO:0007154:cell communication:P", "GO:0016020:membrane:C"], "name": "Calx_beta", "pathway_ids": ["R-RNO-446107", "R-HSA-3000170", "R-HSA-9725554", "R-HSA-3000157", "R-RNO-5578775", "R-HSA-425561", "R-RNO-418359", "R-MMU-5578775", "R-HSA-9619665", "R-RNO-425561", "R-MMU-3000170", "R-MMU-425561", "R-HSA-8949215", "R-MMU-418359", "R-HSA-2022090", "R-HSA-5578775", "R-HSA-446107", "R-RNO-3000170", "R-MMU-446107", "R-HSA-418359"], "pathways": ["R-RNO-446107:r:Type I hemidesmosome assembly", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-425561:r:Sodium/Calcium exchangers", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-RNO-425561:r:Sodium/Calcium exchangers", "R-MMU-3000170:r:Syndecan interactions", "R-MMU-425561:r:Sodium/Calcium exchangers", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-RNO-3000170:r:Syndecan interactions", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Domain"}, "IPR003645": {"description": "Follistatin-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Fol_N", "pathway_ids": ["R-CEL-1592389", "R-MMU-2024096", "R-RNO-3000497", "R-HSA-3560783", "R-HSA-3000178", "R-HSA-9010553", "R-HSA-9918485", "R-HSA-3656237", "R-MMU-8957275", "R-RNO-2024096", "R-MMU-975634", "R-BTA-8957275", "R-MMU-3000178", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-RNO-3000178", "R-HSA-381426", "R-SSC-2473224", "R-HSA-3000171", "R-HSA-1971475", "R-CEL-114608", "R-HSA-9694614", "R-HSA-373752", "R-HSA-419037", "R-BTA-3000497", "R-HSA-9820960", "R-HSA-3560801", "R-RNO-381426", "R-DRE-2473224", "R-MMU-376176", "R-MMU-9913351", "R-HSA-4420332", "R-MMU-114608", "R-HSA-3000497", "R-HSA-1251985", "R-SSC-114608", "R-BTA-201451", "R-HSA-201451", "R-MMU-9010553", "R-MMU-3000497", "R-BTA-2473224", "R-HSA-2473224", "R-RNO-114608", "R-HSA-114608", "R-BTA-114608", "R-HSA-3656253", "R-RNO-2473224", "R-RNO-8957275", "R-BTA-381426", "R-HSA-2024096", "R-MMU-2022928", "R-MMU-201451", "R-HSA-9833110", "R-HSA-2022928", "R-RNO-975634", "R-RNO-201451", "R-HSA-9918481", "R-HSA-216083", "R-HSA-8985801", "R-HSA-428542", "R-HSA-376176", "R-HSA-9913351", "R-MMU-428890", "R-MMU-8985586", "R-RNO-9913351", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-RNO-1971475", "R-RNO-2022928", "R-HSA-428540", "R-HSA-8957275", "R-SSC-3000497", "R-HSA-428890", "R-MMU-2473224", "R-MMU-1971475", "R-HSA-975634"], "pathways": ["R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-2024096:r:HS-GAG degradation", "R-RNO-3000497:r:Scavenging by Class H Receptors", 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"R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-114608:r:Platelet degranulation", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-BTA-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-2473224:r:Antagonism of Activin by Follistatin", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-RNO-2473224:r:Antagonism of Activin by Follistatin", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2024096:r:HS-GAG degradation", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-MMU-201451:r:Signaling by BMP", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-201451:r:Signaling by BMP", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-2022928:r:HS-GAG biosynthesis", 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"R-HSA-9609690", "R-HSA-9754189", "R-HSA-877300", "R-HSA-2173795", "R-MMU-983168", "R-RNO-212436", "R-RNO-9843940", "R-HSA-9843940", "R-HSA-3899300", "R-RNO-983168", "R-HSA-5655302", "R-HSA-212436", "R-RNO-3899300", "R-HSA-1839117"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-212436:r:Generic Transcription Pathway", "R-RNO-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-212436:r:Generic Transcription Pathway", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR003650": {"description": "Orange domain", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Orange_dom", "pathway_ids": ["R-HSA-9013508", "R-HSA-8941856", "R-HSA-210744", "R-HSA-2894862", "R-HSA-9824272", "R-HSA-1368108", "R-HSA-9931510", "R-HSA-9013695", "R-DME-432408", "R-HSA-9733709", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-2122947", "R-HSA-8940973", "R-HSA-9762293"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9824272:r:Somitogenesis", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-DME-432408:r:Transcription regulation of cwo gene", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-9762293:r:Regulation of CDH11 gene transcription"], "type": "Domain"}, "IPR003651": {"description": "Endonuclease III-like, iron-sulphur cluster loop motif", "go_ids": ["GO:0051539"], "go_terms": ["GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Endonuclease3_FeS-loop_motif", "pathway_ids": ["R-HSA-9630222", "R-HSA-110357", "R-HSA-9608287", "R-RNO-110331", "R-HSA-110328", "R-HSA-9608290", "R-RNO-110357", "R-SCE-110329", "R-MMU-110331", "R-BTA-110329", "R-MMU-110357", "R-HSA-110331", "R-BTA-110357", "R-MMU-110329", "R-HSA-110329", "R-HSA-110330", "R-SPO-110331", "R-HSA-9630221"], "pathways": ["R-HSA-9630222:r:Defective NTHL1 substrate binding", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9608287:r:Defective MUTYH substrate binding", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9608290:r:Defective MUTYH substrate processing", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-SCE-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-110331:r:Cleavage of the damaged purine", "R-BTA-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-110331:r:Cleavage of the damaged purine", "R-BTA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-SPO-110331:r:Cleavage of the damaged purine", "R-HSA-9630221:r:Defective NTHL1 substrate processing"], "type": "Conserved_site"}, "IPR003652": {"description": "Ataxin, AXH domain", "go_ids": ["GO:0003723", "GO:0005515"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005515:protein binding:F"], "name": "Ataxin_AXH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003653": {"description": "Ulp1 protease family, C-terminal catalytic domain", "go_ids": ["GO:0006508", "GO:0008234"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008234:cysteine-type peptidase activity:F"], "name": "Peptidase_C48_C", "pathway_ids": ["R-MMU-9035034", "R-MMU-6791226", "R-HSA-8951664", "R-HSA-3065679", "R-DDI-6791226", "R-CEL-9035034", "R-SPO-5689603", "R-MMU-8951664", "R-RNO-5689603", "R-RNO-3065679", "R-SCE-6791226", "R-HSA-9035034", "R-RNO-8951664", "R-HSA-6791226", "R-SCE-3065679", "R-MMU-3065679", "R-SPO-8951664", "R-CEL-6791226", "R-CEL-3065679", "R-SPO-3065679", "R-HSA-5689603", "R-MMU-5689603", "R-DDI-3065679", "R-SPO-6791226"], "pathways": ["R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-8951664:r:Neddylation", "R-HSA-3065679:r:SUMO is proteolytically processed", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9035034:r:RHOF GTPase cycle", "R-SPO-5689603:r:UCH proteinases", "R-MMU-8951664:r:Neddylation", "R-RNO-5689603:r:UCH proteinases", "R-RNO-3065679:r:SUMO is proteolytically processed", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-8951664:r:Neddylation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-3065679:r:SUMO is proteolytically processed", "R-MMU-3065679:r:SUMO is proteolytically processed", "R-SPO-8951664:r:Neddylation", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-3065679:r:SUMO is proteolytically processed", "R-SPO-3065679:r:SUMO is proteolytically processed", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-DDI-3065679:r:SUMO is proteolytically processed", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR003654": {"description": "OAR domain", "go_ids": [], "go_terms": [], "name": "OAR_dom", "pathway_ids": ["R-HSA-8866906", "R-HSA-9834899"], "pathways": ["R-HSA-8866906:r:TFAP2 (AP-2) family regulates transcription of other transcription factors", "R-HSA-9834899:r:Specification of the neural plate border"], "type": "Domain"}, "IPR003656": {"description": "Zinc finger, BED-type", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Znf_BED", "pathway_ids": ["R-HSA-4551638", "R-CEL-4551638"], "pathways": ["R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins"], "type": "Domain"}, "IPR003657": {"description": "WRKY domain", "go_ids": ["GO:0003700", "GO:0043565", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0043565:sequence-specific DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "WRKY_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003658": {"description": "Anti-sigma factor antagonist", "go_ids": ["GO:0043856", "GO:0006355"], "go_terms": ["GO:0043856:anti-sigma factor antagonist activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Anti-sigma_ant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003660": {"description": "HAMP domain", "go_ids": ["GO:0007165", "GO:0016020"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0016020:membrane:C"], "name": "HAMP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003661": {"description": "Signal transduction histidine kinase, dimerisation/phosphoacceptor domain", "go_ids": ["GO:0000155", "GO:0007165"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0007165:signal transduction:P"], "name": "HisK_dim/P_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003663": {"description": "Sugar/inositol transporter", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "Sugar/inositol_transpt", "pathway_ids": ["R-RNO-196836", "R-SCE-6798695", "R-SSC-8981373", "R-PFA-189200", "R-CEL-422356", "R-DME-5653890", "R-MMU-189200", "R-RNO-8981373", "R-RNO-189200", "R-MMU-5653890", "R-PFA-196836", "R-RNO-8856828", "R-DME-8981373", "R-MMU-8981373", "R-SCE-189200", "R-PFA-5653890", "R-MMU-196836", "R-RNO-8856825", "R-DME-6798695", "R-HSA-381340", "R-HSA-5619043", "R-CEL-8981373", "R-HSA-210745", "R-HSA-8981373", "R-RNO-429593", "R-SSC-5653890", "R-HSA-5619047", "R-RNO-422356", "R-HSA-8856825", "R-DME-189200", "R-BTA-422356", "R-SCE-5653890", "R-SPO-429593", "R-HSA-9022699", "R-GGA-352832", "R-PFA-6798695", "R-HSA-5619098", "R-HSA-422356", "R-HSA-6798695", "R-SCE-8981373", "R-MMU-8856828", "R-DME-422356", "R-HSA-8856828", "R-CEL-6798695", "R-BTA-6798695", "R-MMU-429593", "R-RNO-5653890", "R-HSA-5653890", "R-SCE-196836", "R-SSC-422356", "R-BTA-196836", "R-HSA-5619068", "R-DRE-189200", "R-XTR-189200", "R-HSA-196836", "R-DME-196836", "R-SCE-422356", "R-BTA-8981373", "R-SSC-196836", "R-PFA-422356", "R-CEL-5653890", "R-PFA-8981373", "R-HSA-189200", "R-SSC-189200", "R-SCE-429593", "R-BTA-189200", "R-CEL-429593", "R-HSA-1445148", "R-CEL-189200", "R-BTA-5653890", "R-MMU-6798695", "R-HSA-429593", "R-RNO-6798695", "R-SSC-6798695", "R-MMU-8856825", "R-MMU-422356", "R-CEL-196836"], "pathways": ["R-RNO-196836:r:Vitamin C (ascorbate) metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-SSC-8981373:r:Intestinal hexose absorption", "R-PFA-189200:r:Cellular hexose transport", "R-CEL-422356:r:Regulation of insulin secretion", "R-DME-5653890:r:Lactose synthesis", "R-MMU-189200:r:Cellular hexose transport", "R-RNO-8981373:r:Intestinal hexose absorption", "R-RNO-189200:r:Cellular hexose transport", "R-MMU-5653890:r:Lactose synthesis", "R-PFA-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8981373:r:Intestinal hexose absorption", "R-MMU-8981373:r:Intestinal hexose absorption", "R-SCE-189200:r:Cellular hexose transport", "R-PFA-5653890:r:Lactose synthesis", "R-MMU-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-5619043:r:Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)", "R-CEL-8981373:r:Intestinal hexose absorption", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-8981373:r:Intestinal hexose absorption", "R-RNO-429593:r:Inositol transporters", "R-SSC-5653890:r:Lactose synthesis", "R-HSA-5619047:r:Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)", "R-RNO-422356:r:Regulation of insulin secretion", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-189200:r:Cellular hexose transport", "R-BTA-422356:r:Regulation of insulin secretion", "R-SCE-5653890:r:Lactose synthesis", "R-SPO-429593:r:Inositol transporters", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-GGA-352832:r:Glucose transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-HSA-5619098:r:Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-8981373:r:Intestinal hexose absorption", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DME-422356:r:Regulation of insulin secretion", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-429593:r:Inositol transporters", "R-RNO-5653890:r:Lactose synthesis", "R-HSA-5653890:r:Lactose synthesis", "R-SCE-196836:r:Vitamin C (ascorbate) metabolism", "R-SSC-422356:r:Regulation of insulin secretion", "R-BTA-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-5619068:r:Defective SLC2A10 causes arterial tortuosity syndrome (ATS)", "R-DRE-189200:r:Cellular hexose transport", "R-XTR-189200:r:Cellular hexose transport", "R-HSA-196836:r:Vitamin C (ascorbate) metabolism", "R-DME-196836:r:Vitamin C (ascorbate) metabolism", "R-SCE-422356:r:Regulation of insulin secretion", "R-BTA-8981373:r:Intestinal hexose absorption", "R-SSC-196836:r:Vitamin C (ascorbate) metabolism", "R-PFA-422356:r:Regulation of insulin secretion", "R-CEL-5653890:r:Lactose synthesis", "R-PFA-8981373:r:Intestinal hexose absorption", "R-HSA-189200:r:Cellular hexose transport", "R-SSC-189200:r:Cellular hexose transport", "R-SCE-429593:r:Inositol transporters", "R-BTA-189200:r:Cellular hexose transport", "R-CEL-429593:r:Inositol transporters", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-CEL-189200:r:Cellular hexose transport", "R-BTA-5653890:r:Lactose synthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-429593:r:Inositol transporters", "R-RNO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-422356:r:Regulation of insulin secretion", "R-CEL-196836:r:Vitamin C (ascorbate) metabolism"], "type": "Family"}, "IPR003664": {"description": "Fatty acid synthesis PlsX protein", "go_ids": ["GO:0003824", "GO:0006633", "GO:0016747"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0006633:fatty acid biosynthetic process:P", "GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "FA_synthesis", "pathway_ids": ["PWY-5981"], "pathways": ["PWY-5981:t:CDP-diacylglycerol biosynthesis III"], "type": "Family"}, "IPR003666": {"description": "Photosystem I PsaF, reaction centre subunit III", "go_ids": ["GO:0009538", "GO:0015979", "GO:0009522"], "go_terms": ["GO:0009538:photosystem I reaction center:C", "GO:0015979:photosynthesis:P", "GO:0009522:photosystem I:C"], "name": "PSI_PsaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003667": {"description": "NqrDE/RnfAE", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "NqrDE/RnfAE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003669": {"description": "Thymidylate synthase ThyX", "go_ids": ["GO:0006231", "GO:0050660", "GO:0050797"], "go_terms": ["GO:0006231:dTMP biosynthetic process:P", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0050797:thymidylate synthase (FAD) activity:F"], "name": "Thymidylate_synthase_ThyX", "pathway_ids": ["PWY-6545"], "pathways": ["PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III"], "type": "Family"}, "IPR003670": {"description": "African swine fever virus, TBK1 inhibitor DP96R", "go_ids": [], "go_terms": [], "name": "ASFV_DP96R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003671": {"description": "Spindlin/spermiogenesis-specific protein", "go_ids": ["GO:0007276"], "go_terms": ["GO:0007276:gamete generation:P"], "name": "SPIN/Ssty", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003672": {"description": "CobN/magnesium chelatase", "go_ids": ["GO:0009058"], "go_terms": ["GO:0009058:biosynthetic process:P"], "name": "CobN/Mg_chltase", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Domain"}, "IPR003673": {"description": "CoA-transferase family III", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "CoA-Trfase_fam_III", "pathway_ids": ["R-RNO-9033241", "R-MMU-389887", "R-RNO-193775", "R-HSA-193775", "R-MMU-193368", "R-RNO-389887", "R-MMU-193775", "R-RNO-193368", "R-HSA-389887", "R-HSA-193368", "R-MMU-9033241", "R-HSA-9033241"], "pathways": ["R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR003674": {"description": "Oligosaccharyl transferase, STT3 subunit", "go_ids": ["GO:0004576", "GO:0016020", "GO:0009101"], "go_terms": ["GO:0004576:oligosaccharyl transferase activity:F", "GO:0016020:membrane:C", "GO:0009101:glycoprotein biosynthetic process:P"], "name": "Oligo_trans_STT3", "pathway_ids": ["R-MMU-9931295", "R-BTA-9931295", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9918432", "R-BTA-9768727", "R-HSA-9926550", "R-CFA-9931295", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-9931295"], "pathways": ["R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Family"}, "IPR003675": {"description": "CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain", "go_ids": [], "go_terms": [], "name": "Rce1/LyrA-like_dom", "pathway_ids": ["R-CEL-5689880", "R-MMU-5689880", "R-RNO-5689880", "R-BTA-5689880", "R-MMU-9648002", "R-HSA-5689880", "R-BTA-9648002", "R-RNO-9648002", "R-HSA-9648002", "R-DME-5689880", "R-CEL-9648002", "R-DME-9648002"], "pathways": ["R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9648002:r:RAS processing", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-9648002:r:RAS processing", "R-RNO-9648002:r:RAS processing", "R-HSA-9648002:r:RAS processing", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-9648002:r:RAS processing", "R-DME-9648002:r:RAS processing"], "type": "Domain"}, "IPR003676": {"description": "Small auxin-up RNA", "go_ids": ["GO:0009733"], "go_terms": ["GO:0009733:response to auxin:P"], "name": "SAUR_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003677": {"description": "SXP/RAL-2 family protein Ani s 5-like, cation-binding domain", "go_ids": [], "go_terms": [], "name": "ANIS5_cation-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003678": {"description": "Putative outer membrane protein", "go_ids": [], "go_terms": [], "name": "Put_OMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003679": {"description": "Aminoglycoside N(3)-acetyltransferase-like", "go_ids": ["GO:0008080", "GO:0046677"], "go_terms": ["GO:0008080:N-acetyltransferase activity:F", "GO:0046677:response to antibiotic:P"], "name": "Amioglycoside_AcTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003680": {"description": "Flavodoxin-like fold", "go_ids": [], "go_terms": [], "name": "Flavodoxin_fold", "pathway_ids": ["PWY-6370", "PWY-2261", "R-RNO-211945", "R-HSA-350562", "R-HSA-211945", "R-RNO-350562", "R-MMU-211945", "R-HSA-9818027", "R-MMU-350562"], "pathways": ["PWY-6370:t:ascorbate recycling (cytosolic)", "PWY-2261:t:ascorbate glutathione cycle", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)"], "type": "Domain"}, "IPR003681": {"description": "Glycophorin-binding protein", "go_ids": [], "go_terms": [], "name": "Glycophorin-bd", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR003682": {"description": "rRNA small subunit methyltransferase G", "go_ids": ["GO:0005737", "GO:0006364", "GO:0008649"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006364:rRNA processing:P", "GO:0008649:rRNA methyltransferase activity:F"], "name": "rRNA_ssu_MeTfrase_G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003683": {"description": "Cytochrome b6/f complex, subunit 5", "go_ids": ["GO:0009512"], "go_terms": ["GO:0009512:cytochrome b6f complex:C"], "name": "Cyt_6/f_cplx_su5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003684": {"description": "Porin, alpha proteobacteria type", "go_ids": ["GO:0015288", "GO:0016020", "GO:0055085"], "go_terms": ["GO:0015288:porin activity:F", "GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "Porin_alphabac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003685": {"description": "Photosystem I PsaD", "go_ids": ["GO:0009538", "GO:0015979", "GO:0009522"], "go_terms": ["GO:0009538:photosystem I reaction center:C", "GO:0015979:photosynthesis:P", "GO:0009522:photosystem I:C"], "name": "PsaD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003686": {"description": "Photosystem II PsbI", "go_ids": ["GO:0009539", "GO:0015979", "GO:0016020", "GO:0009523"], "go_terms": ["GO:0009539:photosystem II reaction center:C", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C", "GO:0009523:photosystem II:C"], "name": "PSII_PsbI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003687": {"description": "Photosystem II PsbK", "go_ids": ["GO:0009539", "GO:0015979", "GO:0009523"], "go_terms": ["GO:0009539:photosystem II reaction center:C", "GO:0015979:photosynthesis:P", "GO:0009523:photosystem II:C"], "name": "PSII_PsbK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003688": {"description": "Type IV secretion system protein TraG/VirD4", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TraG/VirD4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003689": {"description": "Zinc/iron permease", "go_ids": ["GO:0016020", "GO:0030001", "GO:0046873", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0030001:metal ion transport:P", "GO:0046873:metal ion transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P"], "name": "ZIP", "pathway_ids": ["R-DDI-442380", "R-HSA-442380", "R-DME-442380", "R-XTR-442380", "R-SCE-442380", "R-DRE-442380", "R-PFA-442380", "R-MMU-442380", "R-HSA-5619088", "R-SPO-442380", "R-SSC-442380", "R-BTA-442380", "R-CEL-442380", "R-RNO-442380"], "pathways": ["R-DDI-442380:r:Zinc influx into cells by the SLC39 gene family", "R-HSA-442380:r:Zinc influx into cells by the SLC39 gene family", "R-DME-442380:r:Zinc influx into cells by the SLC39 gene family", "R-XTR-442380:r:Zinc influx into cells by the SLC39 gene family", "R-SCE-442380:r:Zinc influx into cells by the SLC39 gene family", "R-DRE-442380:r:Zinc influx into cells by the SLC39 gene family", "R-PFA-442380:r:Zinc influx into cells by the SLC39 gene family", "R-MMU-442380:r:Zinc influx into cells by the SLC39 gene family", "R-HSA-5619088:r:Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)", "R-SPO-442380:r:Zinc influx into cells by the SLC39 gene family", "R-SSC-442380:r:Zinc influx into cells by the SLC39 gene family", "R-BTA-442380:r:Zinc influx into cells by the SLC39 gene family", "R-CEL-442380:r:Zinc influx into cells by the SLC39 gene family", "R-RNO-442380:r:Zinc influx into cells by the SLC39 gene family"], "type": "Family"}, "IPR003690": {"description": "Transcription termination factor, mitochondrial/chloroplastic", "go_ids": ["GO:0003676", "GO:0043231"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0043231:intracellular membrane-bounded organelle:C"], "name": "MTERF", "pathway_ids": ["R-HSA-9937008", "R-HSA-6793080", "R-HSA-2151201", "R-RNO-5205685", "R-DME-5205685", "R-HSA-163316", "R-HSA-5205685", "R-MMU-5205685", "R-MMU-163316", "R-RNO-163316", "R-DME-163316"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-163316:r:Mitochondrial transcription termination", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-163316:r:Mitochondrial transcription termination", "R-RNO-163316:r:Mitochondrial transcription termination", "R-DME-163316:r:Mitochondrial transcription termination"], "type": "Family"}, "IPR003691": {"description": "Fluoride-specific ion channel FluC", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "FluC", "pathway_ids": [], 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"R-CEL-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-SCE-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Family"}, "IPR003702": {"description": "Acetyl-CoA hydrolase/transferase, N-terminal", "go_ids": 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"R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-SCE-9033241:r:Peroxisomal protein import", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SCE-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Family"}, "IPR003704": {"description": "Acetyl-CoA decarbonylase/synthase complex subunit epsilon", "go_ids": ["GO:0019385"], "go_terms": ["GO:0019385:methanogenesis, from acetate:P"], "name": "CdhB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003705": {"description": "Cobalt transport protein CbiN", "go_ids": ["GO:0006824", "GO:0009236", "GO:0015087", "GO:0016020"], "go_terms": ["GO:0006824:cobalt ion transport:P", "GO:0009236:cobalamin biosynthetic process:P", "GO:0015087:cobalt ion transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "CbiN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003706": {"description": "CstA, N-terminal domain", "go_ids": ["GO:0009267", "GO:0016020"], "go_terms": ["GO:0009267:cellular response to starvation:P", "GO:0016020:membrane:C"], "name": "CstA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003708": {"description": "Bacterial protein export chaperone SecB", "go_ids": ["GO:0015031", "GO:0051262"], "go_terms": ["GO:0015031:protein transport:P", "GO:0051262:protein tetramerization:P"], "name": "SecB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003709": {"description": "D-alanyl-D-alanine carboxypeptidase-like, core domain", "go_ids": ["GO:0006508", "GO:0008233"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008233:peptidase activity:F"], "name": "VanY-like_core_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003710": {"description": "Ketopantoate reductase ApbA/PanE", "go_ids": ["GO:0015940", "GO:0008677"], "go_terms": ["GO:0015940:pantothenate biosynthetic process:P", "GO:0008677:2-dehydropantoate 2-reductase activity:F"], "name": "ApbA", "pathway_ids": ["PWY-6654"], "pathways": ["PWY-6654:t:phosphopantothenate biosynthesis III (archaea)"], "type": "Family"}, "IPR003711": {"description": "CarD-like/TRCF, RNAP-interacting domain", "go_ids": [], "go_terms": [], "name": "CarD-like/TRCF_RID", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR003712": {"description": "Cyanate lyase, C-terminal", "go_ids": ["GO:0009440"], "go_terms": ["GO:0009440:cyanate catabolic process:P"], "name": "Cyanate_lyase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003713": {"description": "Flagellar protein FliS", "go_ids": ["GO:0044780"], "go_terms": ["GO:0044780:bacterial-type flagellum assembly:P"], "name": "FliS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003714": {"description": "PhoH-like protein", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "PhoH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003715": {"description": "Polysaccharide export protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Poly_export_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003716": {"description": "DNA-directed RNA polymerase, omega subunit", "go_ids": ["GO:0003899", "GO:0006351"], "go_terms": ["GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "DNA-dir_RNA_pol_omega", "pathway_ids": ["R-HSA-9639775"], "pathways": ["R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb"], "type": "Family"}, "IPR003717": {"description": "Recombination protein O, RecO", "go_ids": ["GO:0006281", "GO:0006310"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P"], "name": "RecO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003718": {"description": "OsmC/Ohr conserved domain", "go_ids": [], "go_terms": [], "name": "OsmC/Ohr_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003719": {"description": "Phenazine biosynthesis PhzF-like", "go_ids": ["GO:0003824", "GO:0009058"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0009058:biosynthetic process:P"], "name": "Phenazine_PhzF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003720": {"description": "tRNA sulfurtransferase ThiI", "go_ids": ["GO:0016783", "GO:0034227"], "go_terms": ["GO:0016783:sulfurtransferase activity:F", "GO:0034227:tRNA thio-modification:P"], "name": "tRNA_STrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003721": {"description": "Pantoate-beta-alanine ligase", "go_ids": ["GO:0004592", "GO:0015940"], "go_terms": ["GO:0004592:pantoate-beta-alanine ligase activity:F", "GO:0015940:pantothenate biosynthetic process:P"], "name": "Pantoate_ligase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003722": {"description": "Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC", "go_ids": ["GO:0009236", "GO:0016993"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P", "GO:0016993:precorrin-8X methylmutase activity:F"], "name": "Cbl_synth_CobH/CbiC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003723": {"description": "Precorrin-6x reductase", "go_ids": ["GO:0009236", "GO:0016994"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P", "GO:0016994:precorrin-6A reductase activity:F"], "name": "Precorrin-6x_reduct", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003724": {"description": "ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR", "go_ids": ["GO:0005524", "GO:0008817", "GO:0009236"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0008817:corrinoid adenosyltransferase activity:F", "GO:0009236:cobalamin biosynthetic process:P"], "name": "CblAdoTrfase_CobA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003725": {"description": "Molybdenum-binding protein ModE, N-terminal", "go_ids": [], "go_terms": [], "name": "ModE-bd_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003726": {"description": "Homocysteine-binding domain", "go_ids": [], "go_terms": [], "name": "HCY_dom", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-HSA-6798163", "R-MMU-9013407", "R-RNO-6798163", "R-CEL-9759218", "R-RNO-9759218", "R-MMU-6798163", "R-DRE-1614635", "R-RNO-9013407", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-DDI-1614635", "R-MMU-9759218", "R-MMU-1614635", "R-DRE-6798163", "R-HSA-156581", "R-HSA-9759218", "R-HSA-3359467", "R-RNO-156581", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-HSA-6798163:r:Choline catabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-6798163:r:Choline catabolism", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-6798163:r:Choline catabolism", "R-DRE-1614635:r:Sulfur amino acid metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-DRE-6798163:r:Choline catabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-RNO-156581:r:Methylation", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Domain"}, "IPR003728": {"description": "Ribosome maturation factor RimP", "go_ids": ["GO:0042274"], "go_terms": ["GO:0042274:ribosomal small subunit biogenesis:P"], "name": "Ribosome_maturation_RimP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003729": {"description": "Bifunctional nuclease domain", "go_ids": ["GO:0004518"], "go_terms": ["GO:0004518:nuclease activity:F"], "name": "Bi_nuclease_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003730": {"description": "Multi-copper polyphenol oxidoreductase", "go_ids": [], "go_terms": [], "name": "Cu_polyphenol_OxRdtase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003731": {"description": "Dinitrogenase iron-molybdenum cofactor biosynthesis", "go_ids": [], "go_terms": [], "name": "Di-Nase_FeMo-co_biosynth", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003732": {"description": "D-aminoacyl-tRNA deacylase DTD", "go_ids": ["GO:0005737", "GO:0002161", "GO:0051499"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0002161:aminoacyl-tRNA deacylase activity:F", "GO:0051499:D-aminoacyl-tRNA deacylase activity:F"], "name": "Daa-tRNA_deacyls_DTD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003734": {"description": "Domain of unknown function DUF155", "go_ids": [], "go_terms": [], "name": "DUF155", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003735": {"description": "Metal-sensitive transcriptional repressor", "go_ids": ["GO:0006355", "GO:0046872", "GO:0003677"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0046872:metal ion binding:F", "GO:0003677:DNA binding:F"], "name": "Metal_Tscrpt_repr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003736": {"description": "Phenylacetic acid degradation-related domain", "go_ids": [], "go_terms": [], "name": "PAAI_dom", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741", "R-CEL-77289", "R-HSA-77289", "R-MMU-77289"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis", "R-CEL-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation"], "type": "Domain"}, "IPR003737": {"description": "N-acetylglucosaminyl phosphatidylinositol deacetylase-related", "go_ids": [], "go_terms": [], "name": "GlcNAc_PI_deacetylase-related", "pathway_ids": ["R-SPO-162710", "R-HSA-162710", "R-RNO-162710", "R-SCE-162710", "R-MMU-162710", "R-MTU-879325", "R-BTA-162710", "R-MTU-879235", "R-MTU-879299", "R-DDI-162710"], "pathways": ["R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MTU-879325:r:Mycothiol catabolism", "R-BTA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MTU-879235:r:Mycothiol-dependent detoxification", "R-MTU-879299:r:Mycothiol biosynthesis", "R-DDI-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR003738": {"description": "SOS response associated peptidase (SRAP)", "go_ids": ["GO:0106300", "GO:0003697", "GO:0006974"], "go_terms": ["GO:0106300:protein-DNA covalent cross-linking repair:P", "GO:0003697:single-stranded DNA binding:F", "GO:0006974:DNA damage response:P"], "name": "SRAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003739": {"description": "Lysine-2,3-aminomutase/glutamate 2,3-aminomutase", "go_ids": [], "go_terms": [], "name": "Lys_aminomutase/Glu_NH3_mut", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003740": {"description": "Uncharacterised membrane protein YitT", "go_ids": [], "go_terms": [], "name": "YitT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003741": {"description": "LUD domain", "go_ids": [], "go_terms": [], "name": "LUD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003742": {"description": "RNA methyltransferase RlmH", "go_ids": ["GO:0006364", "GO:0008168"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0008168:methyltransferase activity:F"], "name": "RlmH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003743": {"description": "C4-type zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Zf-RING_7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003744": {"description": "Queuosine precursor transporter", "go_ids": [], "go_terms": [], "name": "YhhQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003745": {"description": "Thymidylate synthase MJ0757-like", "go_ids": [], "go_terms": [], "name": "MJ0757-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003746": {"description": "Protein of unknown function DUF167", "go_ids": [], "go_terms": [], "name": "DUF167", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003748": {"description": "Protein of unknown function DUF169", "go_ids": [], "go_terms": [], "name": "DUF169", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003749": {"description": "Sulfur carrier ThiS/MoaD-like", "go_ids": [], "go_terms": [], "name": "ThiS/MoaD-like", "pathway_ids": ["R-MTU-936654", "R-HSA-947581"], "pathways": ["R-MTU-936654:r:Cysteine synthesis from O-phosphoserine", "R-HSA-947581:r:Molybdenum cofactor biosynthesis"], "type": "Family"}, "IPR003750": {"description": "Putative RNA methyltransferase C9orf114-like", "go_ids": [], "go_terms": [], "name": "Put_MeTrfase-C9orf114-like", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR003751": {"description": "Translational regulator CsrA", "go_ids": ["GO:0003723", "GO:0006109", "GO:0006402"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006109:regulation of carbohydrate metabolic process:P", "GO:0006402:mRNA catabolic process:P"], "name": "CsrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003752": {"description": "Disulphide bond formation protein DsbB/BdbC", "go_ids": ["GO:0015035", "GO:0006457", "GO:0016020"], "go_terms": ["GO:0015035:protein-disulfide reductase activity:F", "GO:0006457:protein folding:P", "GO:0016020:membrane:C"], "name": "DiS_bond_form_DsbB/BdbC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003753": {"description": "Exonuclease VII, large subunit", "go_ids": ["GO:0006308", "GO:0008855", "GO:0009318"], "go_terms": ["GO:0006308:DNA catabolic process:P", "GO:0008855:exodeoxyribonuclease VII activity:F", "GO:0009318:exodeoxyribonuclease VII complex:C"], "name": "Exonuc_VII_L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003754": {"description": "Tetrapyrrole biosynthesis, uroporphyrinogen III synthase", "go_ids": ["GO:0004852", "GO:0033014"], "go_terms": ["GO:0004852:uroporphyrinogen-III synthase activity:F", "GO:0033014:tetrapyrrole biosynthetic process:P"], "name": "4pyrrol_synth_uPrphyn_synth", "pathway_ids": ["PWY-5188", "PWY-5189", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "PWY-5189:t:tetrapyrrole biosynthesis II (from glycine)", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Domain"}, "IPR003755": {"description": "HPr(Ser) kinase/phosphorylase", "go_ids": ["GO:0000155", "GO:0000160", "GO:0005524", "GO:0006109"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0005524:ATP binding:F", "GO:0006109:regulation of carbohydrate metabolic process:P"], "name": "HPr(Ser)_kin/Pase", "pathway_ids": ["PWY-7039", "PWY-5107"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-5107:t:phytol salvage pathway"], "type": "Family"}, "IPR003757": {"description": "Photosystem I PsaL, reaction centre subunit XI", "go_ids": ["GO:0009538", "GO:0015979", "GO:0009522"], "go_terms": ["GO:0009538:photosystem I reaction center:C", "GO:0015979:photosynthesis:P", "GO:0009522:photosystem I:C"], "name": "PSI_PsaL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003758": {"description": "Tetraacyldisaccharide 4'-kinase", "go_ids": ["GO:0005524", "GO:0009029", "GO:0009245"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0009029:lipid-A 4'-kinase activity:F", "GO:0009245:lipid A biosynthetic process:P"], "name": "LpxK", "pathway_ids": ["PWY-8245", "PWY-8073", "PWY-8283"], "pathways": ["PWY-8245:t:lipid IVA biosynthesis (P. gingivalis)", "PWY-8073:t:lipid IVA biosynthesis (P. putida)", "PWY-8283:t:lipid IVA biosynthesis (generic)"], "type": "Family"}, "IPR003759": {"description": "Cobalamin (vitamin B12)-binding module, cap domain", "go_ids": [], "go_terms": [], "name": "Cbl-bd_cap", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-MMU-9013407", "R-CEL-9759218", "R-RNO-9759218", "R-RNO-9013407", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-DDI-1614635", "R-MMU-9759218", "R-MMU-1614635", "R-HSA-156581", "R-HSA-9759218", "R-RNO-156581", "R-HSA-3359467", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-156581:r:Methylation", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Domain"}, "IPR003760": {"description": "ABC transporter substrate-binding protein PnrA-like", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "PnrA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003761": {"description": "Exonuclease VII, small subunit", "go_ids": ["GO:0006308", "GO:0008855", "GO:0009318"], "go_terms": ["GO:0006308:DNA catabolic process:P", "GO:0008855:exodeoxyribonuclease VII activity:F", "GO:0009318:exodeoxyribonuclease VII complex:C"], "name": "Exonuc_VII_S", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003762": {"description": "L-arabinose isomerase", "go_ids": ["GO:0008733"], "go_terms": ["GO:0008733:L-arabinose isomerase activity:F"], "name": "Lara_isomerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003763": {"description": "CDP-diacylglycerol pyrophosphatase", "go_ids": ["GO:0008654", "GO:0008715", "GO:0016020"], "go_terms": ["GO:0008654:phospholipid biosynthetic process:P", "GO:0008715:CDP-diacylglycerol diphosphatase activity:F", "GO:0016020:membrane:C"], "name": "CDP-diacylglyc_Pase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003764": {"description": "N-acetylglucosamine-6-phosphate deacetylase", "go_ids": ["GO:0006044", "GO:0008448"], "go_terms": ["GO:0006044:N-acetylglucosamine metabolic process:P", "GO:0008448:N-acetylglucosamine-6-phosphate deacetylase activity:F"], "name": "GlcNAc_6-P_deAcase", "pathway_ids": ["PWY-7395", "PWY-6906", "PWY-7077", "R-DME-446210", "R-RNO-446210", "R-BTA-446210", "R-CEL-446210", "R-MMU-446210", "R-DRE-446210", "R-HSA-446210"], "pathways": ["PWY-7395:t:D-galactosamine and N-acetyl-D-galactosamine degradation", "PWY-6906:t:chitin derivatives degradation", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "R-DME-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-RNO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-BTA-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-CEL-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-DRE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine"], "type": "Family"}, "IPR003765": {"description": "Nitrate reductase chaperone, NarJ", "go_ids": ["GO:0051131"], "go_terms": ["GO:0051131:chaperone-mediated protein complex assembly:P"], "name": "NO3_reductase_chaperone_NarJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003766": {"description": "Uronate isomerase", "go_ids": ["GO:0006064", "GO:0008880"], "go_terms": ["GO:0006064:glucuronate catabolic process:P", "GO:0008880:glucuronate isomerase activity:F"], "name": "Uronate_isomerase", "pathway_ids": ["PWY-7247", "PWY-7248"], "pathways": ["PWY-7247:t:beta-D-glucuronide and D-glucuronate degradation", "PWY-7248:t:pectin degradation II"], "type": "Family"}, "IPR003767": {"description": "Malate/L-lactate dehydrogenase-like", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Malate/L-lactate_DH-like", "pathway_ids": ["PWY-6961"], "pathways": ["PWY-6961:t:L-ascorbate degradation II (bacterial, aerobic)"], "type": "Family"}, "IPR003768": {"description": "Segregation and condensation protein A", "go_ids": [], "go_terms": [], "name": "ScpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003769": {"description": "Adaptor protein ClpS, core", "go_ids": ["GO:0030163"], "go_terms": ["GO:0030163:protein catabolic process:P"], "name": "ClpS_core", "pathway_ids": ["R-SPO-983168", "R-DME-983168", "R-HSA-983168", "R-CEL-983168", "R-MMU-983168"], "pathways": ["R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR003770": {"description": "Endolytic murein transglycosylase", "go_ids": [], "go_terms": [], "name": "MLTG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003772": {"description": "Large ribosomal RNA subunit accumulation protein YceD", "go_ids": [], "go_terms": [], "name": "YceD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003773": {"description": "Menaquinone biosynthesis enzyme", "go_ids": [], "go_terms": [], "name": "Menaquinone_biosynth", "pathway_ids": ["PWY-7371", "PWY-7374"], "pathways": ["PWY-7371:t:1,4-dihydroxy-6-naphthoate biosynthesis II", "PWY-7374:t:1,4-dihydroxy-6-naphthoate biosynthesis I"], "type": "Family"}, "IPR003774": {"description": "AlgH-like", "go_ids": [], "go_terms": [], "name": "AlgH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003775": {"description": "Flagellar assembly factor FliW", "go_ids": ["GO:0044780"], "go_terms": ["GO:0044780:bacterial-type flagellum assembly:P"], "name": "Flagellar_assembly_factor_FliW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003776": {"description": "YcaO-like domain", "go_ids": [], "go_terms": [], "name": "YcaO-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003777": {"description": "XdhC- CoxI", "go_ids": [], "go_terms": [], "name": "XdhC_CoxI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003778": {"description": "Carboxyltransferase domain, subdomain A and B", "go_ids": [], "go_terms": [], "name": "CT_A_B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003779": {"description": "Alkyl hydroperoxide reductase AhpD/CMD-like", "go_ids": [], "go_terms": [], "name": "AhpD/CMD-like", "pathway_ids": ["R-HSA-1222541"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis"], "type": "Domain"}, "IPR003780": {"description": "COX15/CtaA family", "go_ids": ["GO:0016020", "GO:0006784"], "go_terms": ["GO:0016020:membrane:C", "GO:0006784:heme A biosynthetic process:P"], "name": "COX15/CtaA_fam", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848", "R-BTA-9864848", "R-MMU-189451", "R-BTA-189451", "R-HSA-189451", "R-SCE-189451", "R-SPO-189451"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-MMU-189451:r:Heme biosynthesis", "R-BTA-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis"], "type": "Family"}, "IPR003781": {"description": "CoA-binding", "go_ids": [], "go_terms": [], "name": "CoA-bd", "pathway_ids": ["R-HSA-163765", "R-HSA-6798695", "R-SPO-6798695", "R-SPO-75105", "R-CEL-6798695", "R-BTA-6798695", "R-RNO-75105", "R-MMU-75105", "R-BTA-75105", "R-SPO-71403", "R-SSC-71403", "R-CEL-71403", "R-MMU-71403", "R-HSA-75105", "R-SCE-71403", "R-MMU-6798695", "R-DME-71403", "R-DDI-71403", "R-RNO-71403", "R-RNO-6798695", "R-HSA-71403", "R-CEL-75105"], "pathways": ["R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR003782": {"description": "Copper chaperone SCO1/SenC", "go_ids": [], "go_terms": [], "name": "SCO1/SenC", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848", "R-BTA-9864848", "R-HSA-5628897", "R-DRE-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR003783": {"description": "Regulatory protein RecX", "go_ids": ["GO:0006282"], "go_terms": ["GO:0006282:regulation of DNA repair:P"], "name": "Regulatory_RecX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003784": {"description": "BioY protein", "go_ids": ["GO:0015878", "GO:0015225", "GO:0005886"], "go_terms": ["GO:0015878:biotin transport:P", "GO:0015225:biotin transmembrane transporter activity:F", "GO:0005886:plasma membrane:C"], "name": "BioY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003785": {"description": "Creatininase/formamide hydrolase", "go_ids": [], "go_terms": [], "name": "Creatininase/forma_Hydrolase", "pathway_ids": ["PWY-6167"], "pathways": ["PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Family"}, "IPR003786": {"description": "Sulfur carrier protein FdhD", "go_ids": ["GO:0016783"], "go_terms": ["GO:0016783:sulfurtransferase activity:F"], "name": "FdhD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003787": {"description": "Sulphur relay, DsrE/F-like", "go_ids": [], "go_terms": [], "name": "Sulphur_relay_DsrE/F-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003788": {"description": "Protein arginine methyltransferase NDUFAF7", "go_ids": [], "go_terms": [], "name": "NDUFAF7", "pathway_ids": ["R-DME-6799198", "R-MMU-6799198", "R-CEL-6799198", "R-HSA-6799198", "R-DDI-6799198", "R-RNO-6799198", "R-DRE-6799198", "R-XTR-6799198"], "pathways": ["R-DME-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-CEL-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-6799198:r:Complex I biogenesis", "R-XTR-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR003789": {"description": "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like", "go_ids": ["GO:0016884"], "go_terms": ["GO:0016884:carbon-nitrogen ligase activity, with glutamine as amido-N-donor:F"], "name": "Asn/Gln_tRNA_amidoTrase-B-like", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Homologous_superfamily"}, "IPR003790": {"description": "Glycosyl hydrolase-like 10", "go_ids": [], "go_terms": [], "name": "GHL10", "pathway_ids": ["PWY-7529", "PWY-6848", "PWY-7134", "PWY-8435", "PWY-1921", "PWY-7133", "PWY-6784", "PWY-8436", "PWY-7091", "PWY-7074", "PWY-6527", "PWY-6717", "PWY-7647", "PWY-6972", "PWY-8366", "PWY-5976", "PWY-6821", "PWY-6735", "PWY-6906", "PWY-6855", "PWY-7491", "PWY-7057", "PWY-842", "PWY-862", "PWY-6737", "PWY-7445", "PWY-5821", "PWY-6749", "PWY-7056", "PWY-7256"], "pathways": ["PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6848:t:rutin degradation", "PWY-7134:t:rutin degradation (plants)", "PWY-8435:t:yeast mannan degradation", "PWY-1921:t:indole-3-acetate activation II", "PWY-7133:t:quercetin glucoside degradation (Allium)", "PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)", "PWY-8436:t:mammalian high-mannose N-glycan degradation", "PWY-7091:t:linustatin bioactivation", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-6527:t:stachyose degradation", "PWY-6717:t:(1,4)-beta-D-xylan degradation", "PWY-7647:t:ulvan degradation", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8366:t:septacidin biosynthesis", "PWY-5976:t:dhurrin degradation", "PWY-6821:t:kappa-carrageenan degradation", "PWY-6735:t:starch degradation IV", "PWY-6906:t:chitin derivatives degradation", "PWY-6855:t:chitin degradation I (archaea)", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7057:t:cichoriin interconversion", "PWY-842:t:starch degradation I", "PWY-862:t:fructan degradation", "PWY-6737:t:starch degradation V", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-5821:t:dalcochinin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7056:t:daphnin interconversion", "PWY-7256:t:cyanidin diglucoside biosynthesis (acyl-glucose dependent)"], "type": "Domain"}, "IPR003791": {"description": "Protein of unknown function UPF0178", "go_ids": [], "go_terms": [], "name": "UPF0178", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003793": {"description": "UPF0166", "go_ids": [], "go_terms": [], "name": "UPF0166", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003795": {"description": "Protein of unknown function DUF192", "go_ids": [], "go_terms": [], "name": "DUF192", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003796": {"description": "Ribonucleotide reductase regulator NrdR-like", "go_ids": ["GO:0008270", "GO:0045892"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "RNR_NrdR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003797": {"description": "DegV", "go_ids": [], "go_terms": [], "name": "DegV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003798": {"description": "DNA recombination RmuC", "go_ids": [], "go_terms": [], "name": "DNA_recombination_RmuC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003801": {"description": "GTP cyclohydrolase FolE2/MptA", "go_ids": ["GO:0003934"], "go_terms": ["GO:0003934:GTP cyclohydrolase I activity:F"], "name": "GTP_cyclohydrolase_FolE2/MptA", "pathway_ids": ["PWY-6147", "PWY-7852", "PWY-6703", "PWY-5663", "PWY-6983", "PWY-7442"], "pathways": ["PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-7852:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)", "PWY-6703:t:preQ0 biosynthesis", "PWY-5663:t:erythro-tetrahydrobiopterin biosynthesis I", "PWY-6983:t:threo-tetrahydrobiopterin biosynthesis", "PWY-7442:t:drosopterin and aurodrosopterin biosynthesis"], "type": "Family"}, "IPR003802": {"description": "Sporulation regulator WhiA", "go_ids": ["GO:0043937"], "go_terms": ["GO:0043937:regulation of sporulation:P"], "name": "Sporulation_regulator_WhiA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003804": {"description": "L-lactate permease", "go_ids": ["GO:0015129", "GO:0015727", "GO:0005886"], "go_terms": ["GO:0015129:lactate transmembrane transporter activity:F", "GO:0015727:lactate transport:P", "GO:0005886:plasma membrane:C"], "name": "Lactate_perm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003805": {"description": "Adenosylcobinamide-GDP ribazoletransferase", "go_ids": ["GO:0008818", "GO:0051073"], "go_terms": ["GO:0008818:cobalamin 5'-phosphate synthase activity:F", "GO:0051073:adenosylcobinamide-GDP ribazoletransferase activity:F"], "name": "CobS", "pathway_ids": ["PWY-7970", "PWY-7975", "PWY-7969", "PWY-5509", "PWY-7963", "PWY-7964", "PWY-7968", "PWY-7961", "PWY-7966", "PWY-7965", "PWY-7967", "PWY-6269"], "pathways": ["PWY-7970:t:benzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7969:t:5-hydroxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-5509:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I", "PWY-7963:t:4-methylphenyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7964:t:adeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7968:t:5-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7961:t:phenyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7966:t:5-methoxy-6-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7965:t:2-methyladeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7967:t:5-methoxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-6269:t:superpathway of adenosylcobalamin salvage from cobinamide II"], "type": "Family"}, "IPR003806": {"description": "ATP-grasp fold, PylC-type", "go_ids": ["GO:0005524", "GO:0046872"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0046872:metal ion binding:F"], "name": "ATP-grasp_PylC-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003807": {"description": "Domain of unknown function DUF202", "go_ids": [], "go_terms": [], "name": "DUF202", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003808": {"description": "Fe-S metabolism associated domain, SufE-like", "go_ids": [], "go_terms": [], "name": "Fe-S_metab-assoc_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003810": {"description": "Putative manganese efflux pump", "go_ids": [], "go_terms": [], "name": "Mntp/YtaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003811": {"description": "Glycerol-3-phosphate acyltransferase, PlsY", "go_ids": ["GO:0005886", "GO:0008654", "GO:0043772"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0008654:phospholipid biosynthetic process:P", "GO:0043772:acyl-phosphate glycerol-3-phosphate acyltransferase activity:F"], "name": "G3P_acylTferase_PlsY", "pathway_ids": ["PWY-5981"], "pathways": ["PWY-5981:t:CDP-diacylglycerol biosynthesis III"], "type": "Family"}, "IPR003812": {"description": "Fido domain", "go_ids": [], "go_terms": [], "name": "Fido", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003813": {"description": "F420-non-reducing hydrogenase iron-sulfur subunit D", "go_ids": [], "go_terms": [], "name": "MvhD/FlpD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003814": {"description": "Formylmethanofuran dehydrogenase, subunit E domain", "go_ids": [], "go_terms": [], "name": "FmdEsu_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003815": {"description": "S-ribosylhomocysteinase (LuxS)", "go_ids": ["GO:0005506", "GO:0009372", "GO:0043768"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0009372:quorum sensing:P", "GO:0043768:S-ribosylhomocysteine lyase activity:F"], "name": "S-ribosylhomocysteinase", "pathway_ids": ["PWY-6154", "PWY-6151", "PWY-6153"], "pathways": ["PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-6151:t:S-adenosyl-L-methionine salvage I", "PWY-6153:t:autoinducer AI-2 biosynthesis I"], "type": "Family"}, "IPR003816": {"description": "Nitrate reductase, gamma subunit", "go_ids": ["GO:0008940", "GO:0009325"], "go_terms": ["GO:0008940:nitrate reductase activity:F", "GO:0009325:nitrate reductase complex:C"], "name": "Nitrate_red_gam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003817": {"description": "Phosphatidylserine decarboxylase-related", "go_ids": ["GO:0004609", "GO:0008654"], "go_terms": ["GO:0004609:phosphatidylserine decarboxylase activity:F", "GO:0008654:phospholipid biosynthetic process:P"], "name": "PS_Dcarbxylase", "pathway_ids": ["PWY-5669", "R-HSA-1483213"], "pathways": ["PWY-5669:t:phosphatidylserine and phosphatidylethanolamine biosynthesis I", "R-HSA-1483213:r:Synthesis of PE"], "type": "Family"}, "IPR003819": {"description": "TauD/TfdA-like domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "TauD/TfdA-like", "pathway_ids": ["R-RNO-71262", "R-MMU-71262", "R-GGA-71262", "R-SCE-71262", "R-CEL-71262", "R-HSA-71262", "R-BTA-71262"], "pathways": ["R-RNO-71262:r:Carnitine synthesis", "R-MMU-71262:r:Carnitine synthesis", "R-GGA-71262:r:Carnitine synthesis", "R-SCE-71262:r:Carnitine synthesis", "R-CEL-71262:r:Carnitine synthesis", "R-HSA-71262:r:Carnitine synthesis", "R-BTA-71262:r:Carnitine synthesis"], "type": "Domain"}, "IPR003820": {"description": "Potassium-transporting ATPase C chain", "go_ids": ["GO:0006813", "GO:0008556", "GO:0016020"], "go_terms": ["GO:0006813:potassium ion transport:P", "GO:0008556:P-type potassium transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "KdpC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003821": {"description": "1-deoxy-D-xylulose 5-phosphate reductoisomerase", "go_ids": ["GO:0008299", "GO:0030604", "GO:0046872"], "go_terms": ["GO:0008299:isoprenoid biosynthetic process:P", "GO:0030604:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity:F", "GO:0046872:metal ion binding:F"], "name": "DXP_reductoisomerase", "pathway_ids": ["PWY-7560"], "pathways": ["PWY-7560:t:methylerythritol phosphate pathway II"], "type": "Family"}, "IPR003822": {"description": "Paired amphipathic helix", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "PAH", "pathway_ids": ["R-HSA-9022702", "R-MMU-8936459", "R-MMU-9824594", "R-HSA-9824594", "R-HSA-9022692", "R-MMU-3899300", "R-HSA-8936459", "R-HSA-427413", "R-HSA-983231", "R-CEL-9825892", "R-HSA-9022538", "R-CEL-9824594", "R-HSA-9615017", "R-MMU-9022692", "R-HSA-9707564", "R-HSA-400206", "R-HSA-9022699", "R-HSA-3899300", "R-MMU-9825892", "R-HSA-9825892", "R-HSA-9701898", "R-MMU-400206", "R-MMU-9707564"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9022538:r:Loss of MECP2 binding ability to 5mC-DNA", "R-CEL-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Repeat"}, "IPR003823": {"description": "CP12 domain", "go_ids": [], "go_terms": [], "name": "CP12_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003824": {"description": "Undecaprenyl-diphosphatase UppP", "go_ids": ["GO:0016020", "GO:0016311", "GO:0050380"], "go_terms": ["GO:0016020:membrane:C", "GO:0016311:dephosphorylation:P", "GO:0050380:undecaprenyl-diphosphatase activity:F"], "name": "UppP", "pathway_ids": ["PWY-5785"], "pathways": ["PWY-5785:t:di-trans,poly-cis-undecaprenyl phosphate biosynthesis"], "type": "Family"}, "IPR003825": {"description": "Colicin V production, CvpA", "go_ids": ["GO:0009403", "GO:0016020"], "go_terms": ["GO:0009403:toxin biosynthetic process:P", "GO:0016020:membrane:C"], "name": "Colicin-V_CvpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003826": {"description": "S-adenosylmethionine decarboxylase family, prokaryotic", "go_ids": ["GO:0008295", "GO:0004014"], "go_terms": ["GO:0008295:spermidine biosynthetic process:P", "GO:0004014:adenosylmethionine decarboxylase activity:F"], "name": "AdoMetDC_fam_prok", "pathway_ids": ["PWY-6834"], "pathways": ["PWY-6834:t:spermidine biosynthesis III"], "type": "Family"}, "IPR003827": {"description": "tRNA wybutosine-synthesizing protein", "go_ids": [], "go_terms": [], "name": "tRNA_yW-synthesising", "pathway_ids": ["PWY-7286", "R-HSA-6782861"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)"], "type": "Domain"}, "IPR003828": {"description": "Epoxyqueuosine reductase QueH", "go_ids": [], "go_terms": [], "name": "QueH", "pathway_ids": ["PWY-6700", "PWY-8106"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Family"}, "IPR003829": {"description": "Pirin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Pirin_N_dom", "pathway_ids": ["PWY-6848", "R-RNO-8935690", "R-MMU-8935690", "R-HSA-8935690"], "pathways": ["PWY-6848:t:rutin degradation", "R-RNO-8935690:r:Digestion", "R-MMU-8935690:r:Digestion", "R-HSA-8935690:r:Digestion"], "type": "Domain"}, "IPR003830": {"description": "(2R)-phospho-3-sulpholactate synthase, ComA", "go_ids": [], "go_terms": [], "name": "ComA_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003831": {"description": "Protein of unknown function DUF211", "go_ids": [], "go_terms": [], "name": "DUF211", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003832": {"description": "Protein of unknown function DUF212", "go_ids": [], "go_terms": [], "name": "DUF212", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003833": {"description": "Carboxyltransferase domain, subdomain C and D", "go_ids": [], "go_terms": [], "name": "CT_C_D", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003834": {"description": "Cytochrome C biogenesis protein, transmembrane domain", "go_ids": ["GO:0016020", "GO:0017004"], "go_terms": ["GO:0016020:membrane:C", "GO:0017004:cytochrome complex assembly:P"], "name": "Cyt_c_assmbl_TM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003835": {"description": "Glycosyl transferase, family 19", "go_ids": ["GO:0008915", "GO:0009245"], "go_terms": ["GO:0008915:lipid-A-disaccharide synthase activity:F", "GO:0009245:lipid A biosynthetic process:P"], "name": "Glyco_trans_19", "pathway_ids": ["PWY-8245", "PWY-8073", "PWY-8283"], "pathways": ["PWY-8245:t:lipid IVA biosynthesis (P. gingivalis)", "PWY-8073:t:lipid IVA biosynthesis (P. putida)", "PWY-8283:t:lipid IVA biosynthesis (generic)"], "type": "Family"}, "IPR003836": {"description": "Glucokinase", "go_ids": ["GO:0004340", "GO:0005524", "GO:0006096", "GO:0005536", "GO:0051156"], "go_terms": ["GO:0004340:glucokinase activity:F", "GO:0005524:ATP binding:F", "GO:0006096:glycolytic process:P", "GO:0005536:D-glucose binding:F", "GO:0051156:glucose 6-phosphate metabolic process:P"], "name": "Glucokinase", "pathway_ids": ["PWY-5514", "PWY-5661", "PWY-5941", "PWY-7238", "PWY-621", "PWY-2722", "PWY-7385", "PWY-2723"], "pathways": ["PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II", "PWY-5661:t:GDP-alpha-D-glucose biosynthesis", "PWY-5941:t:glycogen degradation II", "PWY-7238:t:sucrose biosynthesis II", "PWY-621:t:sucrose degradation III (sucrose invertase)", "PWY-2722:t:trehalose degradation IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-2723:t:trehalose degradation V"], "type": "Family"}, "IPR003837": {"description": "Glu-tRNAGln amidotransferase C subunit", "go_ids": ["GO:0006450"], "go_terms": ["GO:0006450:regulation of translational fidelity:P"], "name": "GatC", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Family"}, "IPR003838": {"description": "ABC3 transporter permease, C-terminal", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "ABC3_permease_C", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638334", "R-HSA-9760173"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR003839": {"description": "7TM GPCR, serpentine receptor class u (Sru)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Sru", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003840": {"description": "DNA replication helicase domain", "go_ids": ["GO:0004386", "GO:0005524"], "go_terms": ["GO:0004386:helicase activity:F", "GO:0005524:ATP binding:F"], "name": "DNA_helicase_dom", "pathway_ids": ["PWY-7250", "R-HSA-9610379", "R-HSA-9609690"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Domain"}, "IPR003841": {"description": "Sodium-dependent phosphate transport protein", "go_ids": ["GO:0016020", "GO:0005436", "GO:0044341"], "go_terms": ["GO:0016020:membrane:C", "GO:0005436:sodium:phosphate symporter activity:F", "GO:0044341:sodium-dependent phosphate transport:P"], "name": "Na/Pi_transpt", "pathway_ids": ["R-HSA-5619040", "R-HSA-427589", "R-HSA-5619097", "R-HSA-5619045", "R-HSA-5683826", "R-MMU-427589", "R-RNO-427589", "R-RNO-5683826", "R-MMU-5683826", "R-HSA-5687583"], "pathways": ["R-HSA-5619040:r:Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)", "R-HSA-427589:r:Type II Na+/Pi cotransporters", "R-HSA-5619097:r:Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)", "R-HSA-5619045:r:Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)", "R-HSA-5683826:r:Surfactant metabolism", "R-MMU-427589:r:Type II Na+/Pi cotransporters", "R-RNO-427589:r:Type II Na+/Pi cotransporters", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-5687583:r:Defective SLC34A2 causes PALM"], "type": "Family"}, "IPR003842": {"description": "Vacuolating cytotoxin, beta-helical domain", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "VacA_beta-helix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003844": {"description": "Uncharacterised protein family UPF0060", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "UPF0060", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003846": {"description": "Protein adenylyltransferase SelO", "go_ids": [], "go_terms": [], "name": "SelO", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Family"}, "IPR003847": {"description": "Putative antitoxin", "go_ids": [], "go_terms": [], "name": "Put_antitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003848": {"description": "Domain of unknown function DUF218", "go_ids": [], "go_terms": [], "name": "DUF218", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003849": {"description": "Preprotein translocase YajC", "go_ids": [], "go_terms": [], "name": "Preprotein_translocase_YajC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003850": {"description": "Phosphoribosylformylglycinamidine synthase subunit PurS", "go_ids": [], "go_terms": [], "name": "PurS", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis"], "type": "Family"}, "IPR003851": {"description": "Zinc finger, Dof-type", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Znf_Dof", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003852": {"description": "Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004673", "GO:0016020"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F", "GO:0016020:membrane:C"], "name": "Sig_transdc_His_kinase_KdpD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003854": {"description": "Gibberellin regulated protein", "go_ids": [], "go_terms": [], "name": "GASA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003855": {"description": "Potassium transporter", "go_ids": ["GO:0015079", "GO:0016020", "GO:0071805"], "go_terms": ["GO:0015079:potassium ion transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0071805:potassium ion transmembrane transport:P"], "name": "K+_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003856": {"description": "Polysaccharide chain length determinant, N-terminal domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "LPS_length_determ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003857": {"description": "Major outer sheath protein, N-terminal", "go_ids": [], "go_terms": [], "name": "MOSP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003859": {"description": "Beta-1,4-galactosyltransferase", "go_ids": ["GO:0005975", "GO:0016757"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016757:glycosyltransferase activity:F"], "name": "Galactosyl_T", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-6798695", "R-HSA-4793953", "R-DRE-913709", "R-CEL-975577", "R-DRE-975577", "R-DME-1971475", "R-MMU-913709", "R-HSA-3560783", "R-BTA-6798695", "R-CEL-9840309", "R-DRE-9840309", "R-HSA-5653890", "R-DME-975577", "R-BTA-2534343", "R-MMU-5653890", "R-DRE-2022854", "R-BTA-2022854", "R-DME-2022854", "R-RNO-913709", "R-SSC-913709", "R-HSA-1912420", "R-MMU-2534343", "R-SSC-2022854", "R-BTA-975577", "R-HSA-1971475", "R-SSC-975577", "R-MMU-975577", "R-MMU-2022854", "R-DME-9840309", "R-HSA-3656244", "R-RNO-975577", "R-HSA-9840309", "R-HSA-2022854", "R-HSA-2534343", "R-CEL-1971475", "R-RNO-9840309", "R-SSC-9840309", "R-CEL-913709", "R-MMU-9840309", "R-RNO-2022854", "R-HSA-975577", "R-BTA-5653890", "R-MMU-6798695", "R-DME-913709", "R-MMU-1971475", "R-HSA-913709"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-4793953:r:Defective B4GALT1 causes CDG-2d", "R-DRE-913709:r:O-linked glycosylation of mucins", "R-CEL-975577:r:N-Glycan antennae elongation", "R-DRE-975577:r:N-Glycan antennae elongation", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-9840309:r:Glycosphingolipid biosynthesis", "R-DRE-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-5653890:r:Lactose synthesis", "R-DME-975577:r:N-Glycan antennae elongation", "R-BTA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-MMU-5653890:r:Lactose synthesis", "R-DRE-2022854:r:Keratan sulfate biosynthesis", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-DME-2022854:r:Keratan sulfate biosynthesis", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-SSC-913709:r:O-linked glycosylation of mucins", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-BTA-975577:r:N-Glycan antennae elongation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-975577:r:N-Glycan antennae elongation", "R-MMU-975577:r:N-Glycan antennae elongation", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-DME-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-RNO-975577:r:N-Glycan antennae elongation", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-SSC-9840309:r:Glycosphingolipid biosynthesis", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-975577:r:N-Glycan antennae elongation", "R-BTA-5653890:r:Lactose synthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-913709:r:O-linked glycosylation of mucins", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Family"}, "IPR003860": {"description": "Haemagglutinin-esterase glycoprotein, haemagglutinin domain", "go_ids": ["GO:0016788", "GO:0019031", "GO:0019064", "GO:0046789"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F", "GO:0019031:viral envelope:C", "GO:0019064:fusion of virus membrane with host plasma membrane:P", "GO:0046789:host cell surface receptor binding:F"], "name": "Hemagglutn-estrase_hemagglutn", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003861": {"description": "E4 protein", "go_ids": [], "go_terms": [], "name": "Papilloma_E4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003863": {"description": "Domain of unknown function DUF220", "go_ids": [], "go_terms": [], "name": "DUF220", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003864": {"description": "CSC1/OSCA1-like, 7TM region", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "CSC1/OSCA1-like_7TM", "pathway_ids": ["R-SCE-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-SPO-6798695", "R-DME-6798695"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR003869": {"description": "Polysaccharide biosynthesis protein, CapD-like domain", "go_ids": [], "go_terms": [], "name": "Polysac_CapD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003870": {"description": "Domain of unknown function DUF222", "go_ids": [], "go_terms": [], "name": "DUF222", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003871": {"description": "Replication protein A 70 kDa DNA-binding subunit B/D, first OB fold domain", "go_ids": [], "go_terms": [], "name": "RFA1B/D_OB_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003872": {"description": "Major outer sheath protein, C-terminal", "go_ids": [], "go_terms": [], "name": "MOSP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003873": {"description": "Envelope small membrane protein, coronavirus", "go_ids": ["GO:0019068", "GO:0046760", "GO:0016020"], "go_terms": ["GO:0019068:virion assembly:P", "GO:0046760:viral budding from Golgi membrane:P", "GO:0016020:membrane:C"], "name": "E_protein_CoV", "pathway_ids": ["R-HSA-9679509", "R-HSA-9694493", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9692916", "R-HSA-420029", "R-HSA-9692913", "R-HSA-166662", "R-HSA-191650", "R-HSA-9692912", "R-HSA-166663", "R-HSA-9694614", "R-HSA-9705677", "R-HSA-9694322", "R-HSA-9694635", "R-HSA-9683683"], "pathways": ["R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9694493:r:Maturation of protein E", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-420029:r:Tight junction interactions", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-191650:r:Regulation of gap junction activity", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9694635:r:Translation of Structural Proteins", "R-HSA-9683683:r:Maturation of protein E"], "type": "Family"}, "IPR003874": {"description": "CDC45", "go_ids": ["GO:0006270"], "go_terms": ["GO:0006270:DNA replication initiation:P"], "name": "CDC45", "pathway_ids": ["R-SPO-176187", "R-DDI-68962", "R-HSA-176974", "R-HSA-69205", "R-MMU-68962", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-HSA-176187", "R-SCE-176187", "R-SCE-68962"], "pathways": ["R-SPO-176187:r:Activation of ATR in response to replication stress", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-176974:r:Unwinding of DNA", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68962:r:Activation of the pre-replicative complex"], "type": "Family"}, "IPR003875": {"description": "Paramyxoviridae nonstructural protein C", "go_ids": [], "go_terms": [], "name": "Paramyxovir_NSC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003876": {"description": "Arginine deiminase", "go_ids": ["GO:0006527", "GO:0016990"], "go_terms": ["GO:0006527:L-arginine catabolic process:P", "GO:0016990:arginine deiminase activity:F"], "name": "Arg_deiminase", "pathway_ids": ["PWY-6344", "PWY-8187"], "pathways": ["PWY-6344:t:L-arginine degradation XIV (oxidative Stickland reaction)", "PWY-8187:t:L-arginine degradation XIII (reductive Stickland reaction)"], "type": "Family"}, "IPR003877": {"description": "SPRY domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "SPRY_dom", "pathway_ids": ["R-BTA-983168", "R-SCE-9772755", "R-MMU-9909505", "R-MMU-72203", "R-HSA-8851680", "R-HSA-9833482", "R-HSA-5689896", "R-HSA-1834941", "R-HSA-9920588", "R-DME-8951664", "R-MMU-9861718", "R-CEL-72203", "R-HSA-5689880", "R-HSA-8951664", "R-RNO-72163", "R-BTA-9755511", "R-MMU-201722", "R-MMU-8948751", "R-DRE-5673001", "R-HSA-9841922", "R-MMU-8951664", "R-DDI-5675482", "R-MMU-5689880", "R-MMU-9833482", "R-DDI-5213460", "R-MMU-8851805", "R-HSA-9844594", "R-DME-373760", "R-CEL-9770562", "R-HSA-9635465", "R-DDI-5673000", "R-CEL-9772755", "R-MMU-5673001", "R-DME-9909649", "R-HSA-8936459", "R-MMU-8936459", "R-MMU-3214841", "R-DME-9772755", "R-RNO-72203", "R-MMU-72163", "R-MMU-9818564", "R-HSA-6784531", "R-HSA-9660826", "R-MMU-3134975", "R-MMU-5578775", "R-HSA-9755511", "R-DME-9861718", "R-RNO-5689880", "R-HSA-5673001", "R-HSA-3232142", "R-HSA-72163", "R-DDI-5674135", "R-RNO-8951664", "R-HSA-3134975", "R-HSA-8948751", "R-RNO-983168", "R-HSA-5617472", "R-HSA-844456", "R-DRE-8851805", "R-HSA-9833109", "R-DME-983168", "R-BTA-8951664", "R-HSA-9705671", "R-MMU-3232142", "R-HSA-168928", "R-HSA-3769402", "R-HSA-9772755", "R-CEL-8936459", "R-HSA-9944997", "R-HSA-933542", "R-HSA-2672351", "R-HSA-936440", "R-MMU-9755511", "R-HSA-1169408", "R-HSA-373760", "R-HSA-9909505", "R-HSA-9861718", "R-HSA-918233", "R-RNO-2672351", "R-SPO-9772755", 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"IPR003891": {"description": "Initiation factor eIF-4 gamma, MA3", "go_ids": [], "go_terms": [], "name": "Initiation_fac_eIF4g_MI", "pathway_ids": ["R-DDI-975956", "R-MMU-450408", "R-HSA-9010553", "R-HSA-9918487", "R-DME-72163", "R-HSA-156827", "R-HSA-1169408", "R-MMU-72649", "R-MMU-72706", "R-HSA-975956", "R-DRE-72163", "R-HSA-9820865", "R-HSA-166208", "R-MMU-429947", "R-MMU-72662", "R-HSA-450408", "R-CEL-72163", "R-DDI-72662", "R-HSA-9918481", "R-DDI-1169408", "R-MMU-975956", "R-MMU-72702", "R-HSA-429947", "R-MMU-72163", "R-MMU-975957", "R-HSA-72662", "R-DDI-166208", "R-HSA-72706", "R-HSA-8950505", "R-MMU-1169408", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-HSA-72163", "R-HSA-975957", "R-MMU-166208", "R-HSA-9820841", "R-DDI-450408", "R-DDI-975957", "R-SPO-72163", "R-DDI-156827", "R-DDI-72702"], "pathways": ["R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-72649:r:Translation initiation complex formation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-166208:r:mTORC1-mediated signalling", "R-MMU-429947:r:Deadenylation of mRNA", "R-MMU-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-DDI-166208:r:mTORC1-mediated signalling", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-166208:r:mTORC1-mediated signalling", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition"], "type": "Domain"}, "IPR003892": {"description": "Ubiquitin system component CUE", "go_ids": ["GO:0043130"], "go_terms": ["GO:0043130:ubiquitin binding:F"], "name": "CUE", "pathway_ids": ["R-HSA-6798695", "R-HSA-9020702", "R-RNO-9020702", "R-HSA-168638", "R-MMU-5607764", "R-MMU-9020702", "R-BTA-6798695", "R-MMU-937072", "R-CEL-532668", "R-MMU-937042", "R-DRE-445989", "R-HSA-450321", "R-MMU-9954716", "R-MMU-445989", "R-DRE-6798695", "R-HSA-450302", "R-RNO-202424", "R-MMU-975163", "R-RNO-937042", "R-DRE-9020702", "R-DRE-937042", "R-DRE-450321", "R-HSA-532668", "R-RNO-975163", "R-MMU-450321", "R-XTR-6798695", "R-MMU-2871837", "R-RNO-450302", "R-RNO-445989", "R-RNO-168638", "R-MMU-6798695", "R-RNO-6798695", "R-HSA-445989", "R-HSA-9954716", "R-HSA-9705671", "R-HSA-901032", "R-MMU-450302", "R-HSA-937042", "R-RNO-937072", "R-HSA-1251985", "R-MMU-9645460", "R-SCE-6798695", "R-RNO-450321", "R-MMU-5357956", "R-DRE-450302", "R-DRE-532668", "R-HSA-2871837", "R-HSA-112126", "R-RNO-9645460", "R-DRE-975163", "R-XTR-9020702", "R-MMU-532668", "R-MMU-168638", "R-DRE-168638", "R-HSA-937072", "R-HSA-5607764", "R-HSA-9918481", "R-MMU-202424", "R-RNO-2871837", "R-SCE-8876198", "R-HSA-9645460", "R-RNO-5607764", "R-HSA-5357956", "R-HSA-202424", "R-BTA-9020702", "R-HSA-9014325", "R-RNO-5357956", "R-SPO-8876198", "R-DDI-9954716", "R-HSA-975163"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DRE-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DRE-9020702:r:Interleukin-1 signaling", "R-DRE-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DRE-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-XTR-6798695:r:Neutrophil degranulation", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DRE-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-XTR-9020702:r:Interleukin-1 signaling", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling 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"Domain"}, "IPR003894": {"description": "TAFH/NHR1", "go_ids": ["GO:0006351"], "go_terms": ["GO:0006351:DNA-templated transcription:P"], "name": "TAFH_NHR1", "pathway_ids": ["R-CEL-73779", "R-MMU-75953", "R-DME-674695", "R-DME-76042", "R-MMU-6804756", "R-DME-73779", "R-MMU-674695", "R-CEL-73776", "R-DME-6804756", "R-HSA-167162", "R-HSA-167161", "R-CEL-674695", "R-DME-73776", "R-HSA-9827857", "R-HSA-73776", "R-HSA-6804756", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-HSA-674695", "R-HSA-76042", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-CEL-76042", "R-MMU-76042", "R-HSA-73779"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9827857:r:Specification of primordial germ cells", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR003897": {"description": "Clostridium enterotoxin, N-terminal domain", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Clenterotox_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003898": {"description": "Pertussis toxin-like", "go_ids": ["GO:0003950", "GO:0005576"], "go_terms": ["GO:0003950:NAD+ poly-ADP-ribosyltransferase activity:F", "GO:0005576:extracellular region:C"], "name": "PtxA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003900": {"description": "KID repeat", "go_ids": [], "go_terms": [], "name": "KID_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR003901": {"description": "Methyl-coenzyme M reductase, protein D", "go_ids": ["GO:0015948"], "go_terms": ["GO:0015948:methanogenesis:P"], "name": "Me_CoM_Rdtase_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003902": {"description": "Transcription regulator GCM domain", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Tscrpt_reg_GCM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003903": {"description": "Ubiquitin interacting motif", "go_ids": [], "go_terms": [], "name": "UIM_dom", "pathway_ids": ["R-RNO-917729", "R-MMU-8856828", "R-HSA-73772", "R-BTA-9706019", "R-MMU-75953", "R-MMU-917729", "R-BTA-5689880", "R-HSA-5689880", "R-CEL-1660514", "R-HSA-427413", "R-RNO-5693565", "R-MMU-9706019", "R-HSA-5693565", "R-HSA-69231", "R-RNO-5689901", "R-CEL-5689877", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-MMU-69473", "R-MMU-5689880", "R-HSA-73776", "R-MMU-9013420", "R-HSA-69656", "R-MMU-5689877", "R-CEL-182971", "R-DME-432524", "R-HSA-182971", "R-BTA-182971", "R-MMU-9615017", "R-HSA-69473", "R-HSA-432720", "R-DME-209461", "R-RNO-5693571", "R-RNO-5689880", "R-HSA-167161", "R-MMU-69656", "R-HSA-5696395", "R-HSA-167160", "R-CEL-1660517", "R-MMU-73772", "R-MMU-72086", "R-DME-182971", "R-MMU-69273", "R-RNO-9013420", "R-CEL-8856825", "R-MMU-9766229", "R-GGA-5689877", "R-CEL-1660516", "R-DME-432720", "R-HSA-6781827", "R-CEL-9907900", "R-MMU-8939236", "R-MMU-5693565", "R-MMU-69202", "R-HSA-9907900", "R-MMU-6781823", "R-DME-9907900", "R-RNO-9615017", "R-HSA-6782210", "R-SPO-9013420", "R-RNO-8856828", "R-MMU-73776", "R-HSA-5689877", "R-HSA-167172", "R-MMU-5693607", "R-BTA-8856828", "R-CEL-8856828", "R-DME-209360", "R-MMU-6796648", "R-BTA-432720", "R-DDI-9907900", "R-DME-432626", "R-HSA-6807004", "R-CEL-9615017", "R-HSA-917729", "R-RNO-6807004", "R-HSA-5693571", "R-HSA-73863", "R-MMU-77075", "R-HSA-8856825", "R-HSA-75955", "R-CEL-9013420", "R-MMU-6807004", "R-HSA-674695", "R-HSA-76042", "R-BTA-917729", "R-HSA-8875360", "R-HSA-8939236", "R-HSA-112382", "R-HSA-73779", "R-DME-5689880", "R-DME-9013420", "R-MMU-182971", "R-SPO-5689901", "R-SPO-9907900", "R-MMU-113418", "R-HSA-8856828", "R-HSA-69273", "R-MMU-5689901", "R-CEL-432722", "R-HSA-9766229", "R-HSA-6796648", "R-HSA-6781823", "R-DDI-8951664", "R-CEL-917729", "R-SPO-5696395", "R-HSA-167246", "R-MMU-5696395", "R-HSA-5693607", "R-HSA-9635644", "R-RNO-5689877", "R-SPO-8856825", "R-HSA-75953", "R-SCE-9013420", "R-HSA-77075", "R-MMU-73779", "R-MMU-76042", "R-MMU-9907900", "R-RNO-432720", "R-RNO-5693607", "R-MMU-674695", "R-RNO-69473", "R-HSA-167200", "R-SCE-8856825", "R-MMU-6782210", "R-DME-209406", "R-MMU-5693571", "R-MMU-69231", "R-HSA-5689901", "R-MMU-73762", "R-DDI-9755511", "R-MMU-6782135", "R-MMU-8856825", "R-HSA-72086", "R-CFA-5689880", "R-HSA-167162", "R-HSA-9636383", "R-HSA-9615017", "R-HSA-167152", "R-HSA-113418", "R-DME-8856828", "R-DME-216167", "R-GGA-9615017", "R-MMU-432720", "R-SCE-983168", "R-BTA-6807004", "R-DME-917729", "R-BTA-9013420", "R-DME-8856825", "R-DRE-5689880", "R-HSA-9013420", "R-RNO-8856825", "R-CEL-6807004", "R-HSA-9706019", "R-MMU-73863", "R-RNO-9706019", "R-HSA-6782135", "R-HSA-73762", "R-DME-538864", "R-SCE-9907900", "R-BTA-8856825", "R-SPO-5696400", "R-DME-432395", "R-CEL-1660499", "R-RNO-182971", "R-SPO-6782135", "R-HSA-69202"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-69231:r:Cyclin D associated events in G1", "R-RNO-5689901:r:Metalloprotease DUBs", "R-CEL-5689877:r:Josephin domain DUBs", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-5689877:r:Josephin domain DUBs", "R-CEL-182971:r:EGFR downregulation", "R-DME-432524:r:Degradation of PER", "R-HSA-182971:r:EGFR downregulation", "R-BTA-182971:r:EGFR downregulation", "R-MMU-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-167161:r:HIV Transcription Initiation", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-DME-182971:r:EGFR downregulation", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-9013420:r:RHOU GTPase cycle", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9766229:r:Degradation of CDH1", "R-GGA-5689877:r:Josephin domain DUBs", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-CEL-9907900:r:Proteasome assembly", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-9907900:r:Proteasome assembly", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-9907900:r:Proteasome assembly", "R-RNO-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-5689877:r:Josephin domain DUBs", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-9907900:r:Proteasome assembly", "R-DME-432626:r:Circadian Clock pathway", "R-HSA-6807004:r:Negative regulation of MET activity", "R-CEL-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-9013420:r:RHOU GTPase cycle", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-182971:r:EGFR downregulation", "R-SPO-5689901:r:Metalloprotease DUBs", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-5689901:r:Metalloprotease DUBs", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9766229:r:Degradation of CDH1", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-8951664:r:Neddylation", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9635644:r:Inhibition of membrane repair", "R-RNO-5689877:r:Josephin domain DUBs", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-9013420:r:RHOU GTPase cycle", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9907900:r:Proteasome assembly", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-5689901:r:Metalloprotease DUBs", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-72086:r:mRNA Capping", "R-CFA-5689880:r:Ub-specific processing proteases", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-DME-216167:r:Nuclear CI is degraded", "R-GGA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-6807004:r:Negative regulation of MET activity", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-9013420:r:RHOU GTPase cycle", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-6807004:r:Negative regulation of MET activity", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-432395:r:Degradation of TIM", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-182971:r:EGFR downregulation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-69202:r:Cyclin E associated events during G1/S transition"], "type": "Conserved_site"}, "IPR003909": {"description": "G protein-coupled receptor 37 orphan", "go_ids": ["GO:0007186", "GO:0016020"], "go_terms": ["GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "GPR37_orph", "pathway_ids": ["R-HSA-418594", "R-RNO-375276", "R-HSA-375276", "R-MMU-375276", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR003912": {"description": "Protease-activated receptor", "go_ids": ["GO:0007596", "GO:0015057", "GO:0016020", "GO:0070493"], "go_terms": ["GO:0007596:blood coagulation:P", "GO:0015057:thrombin-activated receptor activity:F", "GO:0016020:membrane:C", "GO:0070493:thrombin-activated receptor signaling pathway:P"], "name": "Protea_act_rcpt", "pathway_ids": ["R-MMU-416476", "R-HSA-375276", "R-HSA-456926", "R-RNO-140875", "R-HSA-416476", "R-MMU-375276", "R-HSA-140875", "R-MMU-140875", "R-RNO-456926", "R-MMU-456926", "R-RNO-375276", "R-RNO-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-RNO-416476:r:G alpha (q) signalling events"], "type": "Family"}, "IPR003914": {"description": "Rabaptin", "go_ids": ["GO:0005096", "GO:0006897"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0006897:endocytosis:P"], "name": "Rabaptin", "pathway_ids": ["R-HSA-8854214"], "pathways": ["R-HSA-8854214:r:TBC/RABGAPs"], "type": "Family"}, "IPR003915": {"description": "Polycystic kidney disease type 2 protein", "go_ids": ["GO:0005509", "GO:0016020"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0016020:membrane:C"], "name": "PKD_2", "pathway_ids": ["R-CEL-5620916", "R-HSA-5620916", "R-DRE-5620916", "R-MMU-5620916", "R-BTA-5620916"], "pathways": ["R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5620916:r:VxPx cargo-targeting to cilium"], "type": "Family"}, "IPR003918": {"description": "NADH:ubiquinone oxidoreductase", "go_ids": ["GO:0008137", "GO:0042773"], "go_terms": ["GO:0008137:NADH dehydrogenase (ubiquinone) activity:F", "GO:0042773:ATP synthesis coupled electron transport:P"], "name": "NADH_UbQ_OxRdtase", "pathway_ids": ["R-HSA-5419276", "R-SSC-5419276", "R-HSA-6799198", "R-MMU-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DRE-611105", "R-SSC-6799198", "R-GGA-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-GGA-5419276", "R-RNO-5419276", "R-GGA-611105", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-DRE-5419276", "R-BTA-6799198", "R-SSC-611105", "R-BTA-611105"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", 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Opening", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Family"}, "IPR003929": {"description": "Calcium-activated potassium channel BK, alpha subunit", "go_ids": ["GO:0006813", "GO:0016020"], "go_terms": ["GO:0006813:potassium ion transport:P", "GO:0016020:membrane:C"], "name": "K_chnl_BK_asu", "pathway_ids": ["R-MMU-1300642", "R-RNO-1300642", "R-DME-1300642", "R-HSA-418457", "R-HSA-9662360", "R-HSA-1300642", "R-HSA-9667769", "R-CEL-1300642", "R-HSA-1296052", "R-DRE-1296052", "R-MMU-1296052", "R-DRE-1300642", "R-BTA-1296052", "R-RNO-1296052", "R-PFA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-RNO-1300642:r:Sperm Motility And Taxes", "R-DME-1300642:r:Sperm Motility And Taxes", "R-HSA-418457:r:cGMP effects", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-1300642:r:Sperm Motility And Taxes", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-CEL-1300642:r:Sperm Motility And Taxes", "R-HSA-1296052:r:Ca2+ activated K+ channels", "R-DRE-1296052:r:Ca2+ activated K+ channels", "R-MMU-1296052:r:Ca2+ activated K+ channels", "R-DRE-1300642:r:Sperm Motility And Taxes", "R-BTA-1296052:r:Ca2+ activated K+ channels", "R-RNO-1296052:r:Ca2+ activated K+ channels", "R-PFA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR003930": {"description": "Potassium channel, calcium-activated, BK, beta subunit", "go_ids": ["GO:0006813", "GO:0015269", "GO:0016020"], "go_terms": ["GO:0006813:potassium ion transport:P", "GO:0015269:calcium-activated potassium channel activity:F", "GO:0016020:membrane:C"], "name": "K_chnl_Ca-activ_BK_bsu", "pathway_ids": ["R-HSA-418457", "R-HSA-9662360", "R-HSA-9667769", "R-HSA-1296052", "R-BTA-1296052", "R-MMU-1296052", "R-RNO-1296052"], "pathways": ["R-HSA-418457:r:cGMP effects", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-HSA-1296052:r:Ca2+ activated K+ channels", "R-BTA-1296052:r:Ca2+ activated K+ channels", "R-MMU-1296052:r:Ca2+ activated K+ channels", "R-RNO-1296052:r:Ca2+ activated K+ channels"], "type": "Family"}, "IPR003937": {"description": "Potassium channel, voltage dependent, KCNQ", "go_ids": ["GO:0005249", "GO:0006813", "GO:0016020"], "go_terms": ["GO:0005249:voltage-gated potassium channel activity:F", "GO:0006813:potassium ion transport:P", "GO:0016020:membrane:C"], "name": "K_chnl_volt-dep_KCNQ", "pathway_ids": ["R-HSA-5576890", "R-MMU-5576890", "R-HSA-5576893", "R-BTA-1296072", "R-HSA-9662360", "R-MMU-5576893", "R-HSA-445095", "R-RNO-5576893", "R-HSA-9662361", "R-HSA-1296072", "R-RNO-1296072", "R-MMU-1296072", "R-RNO-5576890"], "pathways": ["R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-MMU-1296072:r:Voltage gated Potassium channels", "R-RNO-5576890:r:Phase 3 - rapid repolarisation"], "type": "Family"}, "IPR003942": {"description": "Left- Right determination factor", "go_ids": ["GO:0005160"], "go_terms": ["GO:0005160:transforming growth factor beta receptor binding:F"], "name": "LRDF", "pathway_ids": ["R-HSA-114608", "R-HSA-1181150", "R-HSA-1433617", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-HSA-1181150:r:Signaling by NODAL", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR003945": {"description": "NADH-quinone oxidoreductase, chain 5-like", "go_ids": ["GO:0008137", "GO:0042773"], "go_terms": ["GO:0008137:NADH dehydrogenase (ubiquinone) activity:F", "GO:0042773:ATP synthesis coupled electron transport:P"], "name": "NU5C-like", "pathway_ids": ["R-HSA-5419276", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-DRE-611105", "R-RNO-6799198", "R-SSC-5419276", "R-SSC-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-RNO-5419276", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9837999", "R-CEL-5419276", "R-SSC-611105", "R-DRE-5419276"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-RNO-6799198:r:Complex I biogenesis", "R-SSC-5419276:r:Mitochondrial translation termination", "R-SSC-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-CEL-5419276:r:Mitochondrial translation termination", "R-SSC-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR003953": {"description": "FAD-dependent oxidoreductase 2, FAD-binding domain", "go_ids": [], "go_terms": [], "name": "FAD-dep_OxRdtase_2_FAD-bd", "pathway_ids": ["R-HSA-9854311", "R-SPO-9854311", "R-DRE-9854311", "R-GGA-372987", "R-SSC-9854311", "R-DRE-71403", "R-HSA-611105", "R-RNO-9854311", "R-DME-9854311", "R-SSC-71403", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-CEL-9854311", "R-MMU-71403", "R-SCE-71403", "R-XTR-9854311", "R-DME-71403", "R-DDI-9854311", "R-DDI-71403", "R-RNO-71403", "R-XTR-71403", "R-HSA-71403", "R-SCE-9854311"], "pathways": ["R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA 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"R-HSA-9918487", "R-RNO-72163", "R-DME-72163", "R-SPO-975957", "R-HSA-72187", "R-MMU-9013408", "R-MMU-9013404", "R-HSA-975956", "R-RNO-73856", "R-MMU-9013422", "R-SPO-9696273", "R-BTA-429947", "R-RNO-72165", "R-CEL-9770562", "R-DME-73856", "R-SSC-73856", "R-HSA-450408", "R-RNO-450408", "R-DME-6782135", "R-BTA-72163", "R-RNO-975957", "R-SPO-975956", "R-BTA-156827", "R-HSA-9694686", "R-RNO-156827", "R-SPO-72706", "R-BTA-450408", "R-RNO-72203", "R-HSA-429947", "R-SCE-975956", "R-MMU-72163", "R-BTA-73856", "R-HSA-6803529", "R-MMU-73856", "R-RNO-9696273", "R-RNO-429947", "R-MMU-159236", "R-HSA-9696264", "R-HSA-9820960", "R-MMU-9013423", "R-RNO-72649", "R-SPO-9770562", "R-HSA-72163", "R-HSA-6791226", "R-HSA-9918476", "R-MMU-9013149", "R-RNO-975956", "R-HSA-9820841", "R-RNO-9696264", "R-BTA-9770562", "R-SPO-156827", "R-HSA-159236", "R-MMU-6804115", "R-MMU-9696264", "R-MMU-9013418", "R-BTA-72649", "R-SPO-429947", "R-SPO-72689", "R-SCE-429947", "R-DDI-975956", "R-SPO-72702", "R-RNO-9696270", "R-SSC-72187", "R-DME-159236", "R-HSA-9682706", "R-HSA-156827", "R-SSC-159236", "R-MMU-72649", "R-DRE-159236", "R-HSA-9820865", "R-DRE-72163", "R-DME-9770562", "R-SCE-975957", "R-DRE-73856", "R-MMU-429947", "R-GGA-72163", "R-MMU-2980766", "R-RNO-159236", "R-GGA-6791226", "R-GGA-9770562", "R-HSA-72165", "R-CEL-72163", "R-HSA-9918481", "R-MMU-2995383", "R-SSC-72165", "R-MMU-975956", "R-RNO-9013418", "R-DRE-156827", "R-SCE-156827", "R-DRE-975956", "R-HSA-72203", "R-GGA-72165", "R-HSA-9770562", "R-HSA-9696270", "R-SPO-72649", "R-BTA-72165", "R-SPO-72695", "R-DME-6798695", "R-MMU-975957", "R-SSC-72163", "R-DRE-975957", "R-DRE-450408", "R-HSA-72649", "R-MMU-156827", "R-SSC-72203", "R-DRE-72649", "R-SCE-72649", "R-HSA-975957", "R-MMU-72187", "R-MMU-72165", "R-BTA-975956", "R-RNO-9770562", "R-DDI-450408", "R-BTA-159236", "R-MMU-4419969", "R-DDI-975957", "R-DME-6782210", "R-SSC-9770562", "R-MMU-9696270", "R-BTA-72203", "R-MMU-9696273", "R-DDI-156827", "R-HSA-9696273"], "pathways": 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"R-RNO-9929356", "R-RNO-6782210", "R-SCE-6811434", "R-BTA-5687128", "R-SPO-9603798", "R-RNO-6811438", "R-HSA-5678895", "R-SCE-9755511", "R-HSA-9694614", "R-HSA-4641258", "R-GGA-5656169", "R-RNO-174184", "R-BTA-4641258", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-RNO-8949664", "R-SCE-6782135", "R-MMU-5610780", "R-DME-9954709", "R-XTR-8876725", "R-MMU-9755511", "R-MMU-6807878", "R-HSA-6811440", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-SCE-9668328", "R-HSA-5362768", "R-DDI-9954709", "R-RNO-8852276", "R-BTA-174178", "R-HSA-5685938", "R-BTA-9907900", "R-DDI-69017", "R-MMU-5655862", "R-BTA-8948751", "R-SCE-6807878", "R-RNO-9929491", "R-HSA-1236978", "R-SPO-8876725", "R-RNO-110320", "R-DME-3371511", "R-MMU-912446", "R-HSA-5632684", "R-SCE-68962", "R-BTA-8854050", "R-XTR-5358346", "R-DRE-110320", "R-RNO-5607764", "R-XTR-9755511", "R-BTA-5607764", "R-DDI-450408", "R-SPO-6782135", "R-CEL-350562", "R-XTR-5689896", "R-BTA-174411", "R-CEL-5632684", "R-HSA-5689880", "R-BTA-1234176", "R-GGA-110314", "R-MMU-69017", "R-RNO-5655862", "R-BTA-350562", "R-BTA-176187", "R-CEL-110320", "R-XTR-9931269", "R-DME-2467813", "R-HSA-8949664", "R-HSA-1234176", "R-RNO-4641258", "R-MMU-68867", "R-HSA-9931269", "R-DRE-9931269", "R-BTA-6782135", "R-DME-209461", "R-CEL-6782210", "R-DRE-9603798", "R-SCE-8951664", "R-DME-75815", "R-SPO-110314", "R-RNO-5693568", "R-DME-69601", "R-CEL-4608870", "R-DME-69017", "R-DME-983168", "R-SCE-8876725", "R-HSA-5610785", "R-HSA-6811438", "R-HSA-2467813", "R-RNO-5676590", "R-BTA-195253", "R-SCE-6798695", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-DME-9907900", "R-RNO-4641257", "R-BTA-5651801", "R-RNO-5685938", "R-DDI-5689603", "R-CEL-75815", "R-HSA-68962", "R-MMU-532668", "R-DRE-9668328", "R-MMU-9762114", "R-BTA-5696400", "R-HSA-5689877", "R-SCE-176187", "R-HSA-176187", "R-MMU-195253", "R-HSA-9603798", "R-MMU-202424", "R-MMU-382556", "R-DME-209360", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-HSA-9841251", "R-RNO-75815", "R-MMU-1169091", "R-CEL-9931269", "R-HSA-5651801", "R-XTR-8951664", "R-DME-8854050", "R-DME-5656169", "R-MMU-8939902", "R-HSA-5696400", "R-SPO-68949", "R-BTA-917729", "R-XTR-382556", "R-HSA-8939236", "R-CEL-6811434", "R-DDI-8854050", "R-BTA-983168", "R-SPO-6807878", "R-BTA-5685938", "R-MMU-5607764", "R-SCE-69091", "R-DRE-8951664", "R-BTA-5668541", "R-DME-5656121", "R-HSA-5676590", "R-DDI-5632684", "R-CEL-6811440", "R-SPO-9668328", "R-HSA-4641257", "R-BTA-9837999", "R-RNO-202424", "R-HSA-174113", "R-BTA-9762114", "R-MMU-5693568", "R-MMU-9603798", "R-RNO-5607761", "R-HSA-5656121", "R-GGA-5696400", "R-CEL-4641258", "R-CEL-9837999", "R-MMU-5651801", "R-DME-9668328", "R-HSA-9755511", "R-RNO-9931269", "R-HSA-110312", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-SPO-68689", "R-RNO-532668", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-CEL-8949664", "R-MMU-68616", "R-CEL-5651801", "R-RNO-5689896", "R-MMU-5696397", "R-MMU-174411", "R-DME-450408", "R-BTA-8939902", "R-HSA-110314", "R-SPO-5651801", "R-BTA-9766229", "R-HSA-3371511", "R-HSA-8876725", "R-HSA-187577", "R-SPO-68616", "R-RNO-68962", "R-DDI-9755511", "R-DME-382556", "R-DME-5610780", "R-RNO-9603798", "R-DME-195253", "R-MMU-69601", "R-SCE-68949", "R-DME-110312", "R-HSA-8866910", "R-DME-5607761", "R-MMU-8854050", "R-CEL-5656169", "R-SPO-5689896", "R-MMU-5689603", "R-HSA-5656169", "R-HSA-5607764", "R-DME-9013407", "R-MMU-416993", "R-CEL-1236978", "R-GGA-351451", "R-RNO-4608870", "R-GGA-5696397", "R-DRE-3371511", "R-HSA-390471", "R-DDI-69091", "R-RNO-6811434", "R-BTA-9603798", "R-RNO-6782135", "R-DME-9837999", "R-CEL-5655862", "R-HSA-6807878", "R-HSA-174411", "R-DME-532668", "R-RNO-204005", "R-DME-538864", "R-RNO-69091", "R-SCE-9907900", "R-DME-68689", "R-HSA-5668541", "R-CEL-68949", "R-DME-5632684", "R-HSA-5687128", "R-SPO-5696400", "R-DME-432395", "R-DRE-8876725", "R-DME-8949664", "R-SCE-3371511", "R-DDI-174178", "R-HSA-110320", "R-MMU-69091", "R-RNO-912446"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-5689877:r:Josephin domain DUBs", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SPO-5689880:r:Ub-specific processing proteases", "R-CEL-9013407:r:RHOH GTPase cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-MMU-9013407:r:RHOH GTPase cycle", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6811438:r:Intra-Golgi traffic", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-GGA-110312:r:Translesion synthesis by REV1", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-9824272:r:Somitogenesis", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-912446:r:Meiotic recombination", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-69091:r:Polymerase switching", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-PFA-68949:r:Orc1 removal from chromatin", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-CEL-69091:r:Polymerase switching", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-BTA-9033241:r:Peroxisomal protein import", "R-CEL-5689603:r:UCH proteinases", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-XTR-9013407:r:RHOH GTPase cycle", "R-CEL-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-CEL-110312:r:Translesion synthesis by REV1", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-SPO-5689603:r:UCH proteinases", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DRE-5689877:r:Josephin domain DUBs", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-SPO-110312:r:Translesion synthesis by REV1", "R-MMU-110312:r:Translesion synthesis by REV1", "R-DME-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-GGA-353303:r:Nucleotide Excision Repair", "R-DME-5689603:r:UCH proteinases", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-CEL-6811438:r:Intra-Golgi traffic", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9907900:r:Proteasome assembly", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-BTA-5689603:r:UCH proteinases", "R-SPO-3371511:r:HSF1 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"R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-MMU-8949664:r:Processing of SMDT1", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SSC-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-5693607:r:Processing of DNA double-strand break ends", 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"R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-9610379:r:HCMV Late Events", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9907900:r:Proteasome assembly", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-9865881:r:Complex III assembly", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DME-110320:r:Translesion Synthesis by POLH", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-69091:r:Polymerase switching", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-SPO-6811438:r:Intra-Golgi traffic", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-GGA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5689603:r:UCH proteinases", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8951664:r:Neddylation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-110312:r:Translesion synthesis by REV1", "R-HSA-69205:r:G1/S-Specific Transcription", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", 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"R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-8876725:r:Protein methylation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-9646399:r:Aggrephagy", "R-MMU-6811438:r:Intra-Golgi traffic", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DME-68962:r:Activation of the pre-replicative complex", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-5655862:r:Translesion synthesis by POLK", "R-BTA-69481:r:G2/M Checkpoints", "R-MMU-3371511:r:HSF1 activation", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-3371511:r:HSF1 activation", "R-GGA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate 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"R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-XTR-110320:r:Translesion Synthesis by POLH", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-110312:r:Translesion synthesis by REV1", "R-XTR-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-BTA-202424:r:Downstream TCR signaling", "R-GGA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-SPO-69091:r:Polymerase switching", "R-RNO-5689877:r:Josephin domain DUBs", "R-HSA-9678110:r:Attachment and Entry", "R-DRE-6798695:r:Neutrophil degranulation", "R-DRE-9013407:r:RHOH GTPase cycle", 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"R-HSA-9020933", "R-RNO-163125", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-381426", "R-HSA-204005", "R-MMU-373753", "R-BTA-445355", "R-MMU-445095", "R-MMU-9013406", "R-HSA-5635838", "R-MMU-6798695", "R-MMU-202427", "R-MMU-9027276", "R-GGA-9843970", "R-RNO-376172", "R-MMU-416700", "R-CEL-419037", "R-MMU-114608", "R-CEL-8863795", "R-HSA-9725554", "R-DME-419037", "R-HSA-74751", "R-HSA-5654687", "R-HSA-977225", "R-MMU-112411", "R-RNO-373760", "R-RNO-1059683", "R-HSA-375165", "R-RNO-114608", "R-BTA-5627123", "R-RNO-5689603", "R-HSA-416700", "R-CEL-3928663", "R-RNO-110056", "R-DME-5689603", "R-DME-9009391", "R-MMU-110056", "R-HSA-525793", "R-DME-2024096", "R-HSA-2214320", "R-HSA-9020591", "R-MMU-1170546", "R-CEL-210991", "R-DRE-9843940", "R-HSA-216083", "R-RNO-390522", "R-HSA-445355", "R-HSA-373756", "R-CEL-445144", "R-MMU-428890", "R-RNO-982772", "R-HSA-983168", "R-RNO-196108", "R-BTA-8932505", "R-RNO-2428928", "R-DME-447043", "R-MMU-1059683", "R-RNO-74751", "R-HSA-3928663", "R-HSA-5627123", "R-MMU-6783783", "R-MMU-416482", "R-MMU-3928662", "R-HSA-390522", "R-GGA-190373", "R-HSA-9843940", "R-DRE-3928665", "R-HSA-8957275", "R-HSA-9013406", "R-CEL-376176", "R-MMU-912694", "R-RNO-449836", "R-BTA-6785807", "R-CEL-5218920", "R-MMU-2129379", "R-MMU-418885", "R-RNO-445095", "R-RNO-6785807", "R-CEL-3928664", "R-MMU-210991", "R-MMU-1266695", "R-HSA-3000178", "R-RNO-1474228", "R-HSA-9006335", "R-RNO-2428933", "R-HSA-9918485", "R-MMU-9013408", "R-RNO-9009391", "R-RNO-373753", "R-CEL-3000178", "R-RNO-5687128", "R-MMU-210993", "R-MMU-9009391", "R-MMU-445355", "R-RNO-8854691", "R-MMU-3000170", "R-RNO-525793", "R-BTA-912694", "R-RNO-9634597", "R-HSA-202427", "R-MMU-5632681", "R-HSA-2979096", "R-MMU-9013420", "R-RNO-6811558", "R-BTA-9020558", "R-CEL-388844", "R-SSC-982772", "R-HSA-2682334", "R-HSA-9616222", "R-DME-209209", "R-HSA-446107", "R-HSA-447038", "R-MMU-5673001", "R-HSA-210500", "R-HSA-9027283", "R-MMU-449836", "R-HSA-9701898", "R-BTA-140834", "R-HSA-2586552", "R-HSA-1474228", "R-MMU-77387", "R-HSA-181430", "R-MMU-3214841", "R-HSA-182971", "R-RNO-1566977", "R-MMU-9843940", "R-RNO-445144", "R-DME-433692", "R-HSA-416482", "R-CEL-447043", "R-HSA-8983432", "R-BTA-8983432", "R-SSC-9027284", "R-HSA-447041", "R-DRE-8849932", "R-GGA-5674135", "R-HSA-9696264", "R-MMU-9013423", "R-MMU-376176", "R-HSA-2022090", "R-RNO-9006335", "R-RNO-8951664", "R-MMU-193648", "R-HSA-445144", "R-MMU-5627123", "R-MMU-9851151", "R-MMU-5687128", "R-HSA-9031628", "R-GGA-8932505", "R-BTA-77387", "R-HSA-212676", "R-HSA-8985947", "R-MMU-9860927", "R-MMU-446107", "R-RNO-6798695", "R-HSA-9656223", "R-GGA-9634597", "R-CEL-8849932", "R-DME-983168", "R-DME-5673001", "R-HSA-9705671", "R-HSA-445095", "R-HSA-9772755", "R-RNO-9851151", "R-MMU-8980692", "R-GGA-163125", "R-MMU-9020956", "R-HSA-2428933", "R-HSA-373760", "R-RNO-9027284", "R-MMU-388844", "R-DME-209338", "R-HSA-9013423", "R-HSA-181429", "R-HSA-9638630", "R-BTA-1266695", "R-MMU-8874081", "R-BTA-912526", "R-HSA-9843970", "R-CEL-373752", "R-MMU-512988", "R-MMU-9772755", "R-GGA-381426", "R-MMU-9027284", "R-HSA-1442490", "R-DRE-8957275", "R-MMU-3928664", "R-CEL-9013423", "R-HSA-9020558", "R-RNO-1170546", "R-MMU-877312", "R-HSA-9027276", "R-MMU-437239", "R-DME-428542", "R-HSA-2129379", "R-HSA-8939247", "R-RNO-446107", "R-MMU-212676", "R-RNO-416700", "R-HSA-8985801", "R-BTA-388844", "R-CFA-6788467", "R-RNO-2682334", "R-RNO-447043", "R-DME-5658623", "R-RNO-181430", "R-MMU-9706369", "R-HSA-376176", "R-SSC-9006335", "R-GGA-114608", "R-MMU-8983432", "R-MMU-447043", "R-CEL-77387", "R-CEL-3928665", "R-DME-1474228", "R-CFA-6785807", "R-RNO-3214847", "R-DME-3214847", "R-MMU-1650814", "R-HSA-74752", "R-HSA-912526", "R-HSA-877300", "R-GGA-3214841", "R-CEL-9013420", "R-MMU-6807004", "R-MMU-525793", "R-MMU-9013149", "R-RNO-3000170", "R-RNO-419037", "R-HSA-9020956", "R-HSA-202733", "R-MMU-373760", "R-DRE-1433557", "R-CEL-433692", "R-GGA-372708", "R-MMU-74749", "R-HSA-5688849", "R-MMU-8985947", "R-MMU-182971", "R-MMU-163125", "R-BTA-983168", "R-HSA-5674135", "R-MMU-204005", "R-CEL-373753", "R-HSA-9700645", "R-DME-375165", "R-MMU-9020933", "R-CEL-9013424", "R-RNO-74749", "R-GGA-354194", "R-RNO-9013149", "R-RNO-9020956", "R-HSA-9013424", "R-MMU-9013404", "R-MMU-8957275", "R-HSA-3928662", "R-HSA-1650814", "R-MMU-2214320", "R-HSA-4420097", "R-DME-9749641", "R-MMU-3000178", "R-HSA-9649948", "R-RNO-202733", "R-GGA-8957275", "R-MMU-9020558", "R-GGA-3000170", "R-HSA-6783783", "R-HSA-381426", "R-GGA-8854691", "R-RNO-2404192", "R-HSA-8932505", "R-MMU-8849932", "R-CEL-9764561", "R-MMU-390522", "R-MMU-982772", "R-GGA-202733", "R-MMU-445144", "R-HSA-6785807", "R-HSA-8854691", "R-RNO-77387", "R-DRE-210993", "R-RNO-418885", "R-HSA-982772", "R-DME-388844", "R-HSA-9013404", "R-MMU-264642", "R-HSA-9013149", "R-DME-110478", "R-HSA-8980692", "R-HSA-5688890", "R-DME-445144", "R-HSA-5683826", "R-RNO-264642", "R-HSA-418890", "R-MMU-376172", "R-HSA-5689603", "R-HSA-9860927", "R-GGA-5654687", "R-HSA-372708", "R-HSA-376172", "R-RNO-8849932", "R-HSA-9674555", "R-RNO-983168", "R-RNO-181429", "R-CEL-6809371", "R-MMU-375165", "R-MMU-419037", "R-CEL-375165", "R-HSA-449836", "R-HSA-2122948", "R-MMU-8856825", "R-HSA-3000157", "R-HSA-9034015", "R-MMU-8948216", "R-HSA-418889", "R-HSA-418886", "R-MMU-9010553", "R-CEL-416700", "R-HSA-416476", "R-HSA-418885", "R-RNO-354194", "R-RNO-2129379", "R-CEL-9013149", "R-MMU-372708", "R-CEL-418885", "R-CEL-1474228", "R-HSA-76009", "R-RNO-418889", "R-HSA-3214841", "R-HSA-6802946", "R-RNO-8957275", "R-DME-9913351", "R-MMU-2428928", "R-HSA-912694", "R-MMU-6788467", "R-RNO-5654687", "R-MMU-5689603", "R-RNO-373752", "R-RNO-8932505", "R-HSA-354192", "R-DRE-2682334", "R-MMU-8854691", "R-HSA-193648", "R-RNO-112411", "R-MMU-8932505", "R-CEL-9913351", "R-HSA-9013420", "R-RNO-210991", "R-DME-376172", "R-SSC-9027276", "R-MMU-8984722", "R-DRE-9843970", "R-HSA-1566977", "R-DME-77387", "R-HSA-428542", "R-BTA-9020958", "R-HSA-190373", "R-MMU-2682334", "R-MMU-3928663", "R-MMU-8985586", "R-HSA-354194", "R-HSA-9679191", "R-MMU-9006335", "R-MMU-181429", "R-MMU-877300", "R-HSA-1433557", "R-MMU-2404192", "R-HSA-9851151", "R-DME-8849932", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-DME-2022928"], "pathways": ["R-GGA-1566977:r:Fibronectin matrix formation", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-1442490:r:Collagen degradation", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8951664:r:Neddylation", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-74752:r:Signaling by Insulin receptor", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-GGA-354192:r:Integrin signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-3000178:r:ECM proteoglycans", "R-DRE-3928664:r:Ephrin signaling", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-HSA-5632681:r:Ligand-receptor interactions", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-8948216:r:Collagen chain trimerization", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-CEL-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-HSA-74713:r:IRS activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DME-210991:r:Basigin interactions", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-GGA-2129379:r:Molecules associated with elastic fibres", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-437239:r:Recycling pathway of L1", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-416700:r:Other semaphorin interactions", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-GGA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-354192:r:Integrin signaling", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9634597:r:GPER1 signaling", "R-BTA-8985947:r:Interleukin-9 signaling", "R-GGA-3000178:r:ECM proteoglycans", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9824272:r:Somitogenesis", "R-CEL-2024096:r:HS-GAG degradation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-114608:r:Platelet degranulation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9020591:r:Interleukin-12 signaling", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-354192:r:Integrin signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-XTR-8932505:r:DAG1 core M3 glycosylations", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-449836:r:Other interleukin signaling", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-MMU-74713:r:IRS activation", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-XTR-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5632681:r:Ligand-receptor interactions", "R-CEL-9749641:r:Aspirin ADME", "R-HSA-74749:r:Signal attenuation", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-RNO-74713:r:IRS activation", "R-GGA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-428540:r:Activation of RAC1", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-HSA-186797:r:Signaling by PDGF", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SSC-9020591:r:Interleukin-12 signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-74752:r:Signaling by Insulin receptor", "R-MMU-373756:r:SDK interactions", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-373752:r:Netrin-1 signaling", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-1266695:r:Interleukin-7 signaling", "R-CEL-525793:r:Myogenesis", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-447043:r:Neurofascin interactions", "R-CEL-216083:r:Integrin cell surface interactions", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-5635838:r:Activation of SMO", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-210993:r:Tie2 Signaling", "R-GGA-216083:r:Integrin cell surface interactions", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9020933:r:Interleukin-23 signaling", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-373753:r:Nephrin family interactions", "R-BTA-445355:r:Smooth Muscle Contraction", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-5635838:r:Activation of SMO", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-GGA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-RNO-376172:r:DSCAM interactions", "R-MMU-416700:r:Other semaphorin interactions", "R-CEL-419037:r:NCAM1 interactions", "R-MMU-114608:r:Platelet degranulation", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-DME-419037:r:NCAM1 interactions", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-373760:r:L1CAM interactions", "R-RNO-1059683:r:Interleukin-6 signaling", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-114608:r:Platelet degranulation", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5689603:r:UCH proteinases", "R-HSA-416700:r:Other semaphorin interactions", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DME-5689603:r:UCH proteinases", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-525793:r:Myogenesis", "R-DME-2024096:r:HS-GAG degradation", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-210991:r:Basigin interactions", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-373756:r:SDK interactions", "R-CEL-445144:r:Signal transduction by L1", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-BTA-8932505:r:DAG1 core M3 glycosylations", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-DME-447043:r:Neurofascin interactions", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-MMU-6783783:r:Interleukin-10 signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-390522:r:Striated Muscle Contraction", "R-GGA-190373:r:FGFR1c ligand binding and activation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-CEL-376176:r:Signaling by ROBO receptors", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-449836:r:Other interleukin signaling", "R-BTA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-418885:r:DCC mediated attractive signaling", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-210991:r:Basigin interactions", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-373753:r:Nephrin family interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-210993:r:Tie2 Signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-MMU-3000170:r:Syndecan interactions", "R-RNO-525793:r:Myogenesis", "R-BTA-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-9634597:r:GPER1 signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-9020558:r:Interleukin-2 signaling", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-SSC-982772:r:Growth hormone receptor signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-DME-209209:r:Formation of the activated receptor complex", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-447038:r:NrCAM interactions", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-182971:r:EGFR downregulation", "R-RNO-1566977:r:Fibronectin matrix formation", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-RNO-445144:r:Signal transduction by L1", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-447043:r:Neurofascin interactions", "R-HSA-8983432:r:Interleukin-15 signaling", "R-BTA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-447041:r:CHL1 interactions", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-RNO-8951664:r:Neddylation", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9031628:r:NGF-stimulated transcription", "R-GGA-8932505:r:DAG1 core M3 glycosylations", "R-BTA-77387:r:Insulin receptor recycling", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-GGA-9634597:r:GPER1 signaling", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-373760:r:L1CAM interactions", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-CEL-373752:r:Netrin-1 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-HSA-1442490:r:Collagen degradation", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-HSA-9020558:r:Interleukin-2 signaling", "R-RNO-1170546:r:Prolactin receptor signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-437239:r:Recycling pathway of L1", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-416700:r:Other semaphorin interactions", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-CFA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-RNO-447043:r:Neurofascin interactions", "R-DME-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-376176:r:Signaling by ROBO receptors", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-GGA-114608:r:Platelet degranulation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-MMU-447043:r:Neurofascin interactions", "R-CEL-77387:r:Insulin receptor recycling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-CFA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-74752:r:Signaling by Insulin receptor", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-GGA-3214841:r:PKMTs methylate histone lysines", "R-CEL-9013420:r:RHOU GTPase cycle", "R-MMU-6807004:r:Negative regulation of MET activity", "R-MMU-525793:r:Myogenesis", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-RNO-419037:r:NCAM1 interactions", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-373760:r:L1CAM interactions", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-CEL-433692:r:Proton-coupled monocarboxylate transport", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-74749:r:Signal attenuation", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-CEL-373753:r:Nephrin family interactions", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9020933:r:Interleukin-23 signaling", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-74749:r:Signal attenuation", "R-GGA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2214320:r:Anchoring fibril formation", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9749641:r:Aspirin ADME", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-MMU-9020558:r:Interleukin-2 signaling", "R-GGA-3000170:r:Syndecan interactions", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-8854691:r:Interleukin-20 family signaling", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-MMU-390522:r:Striated Muscle Contraction", "R-MMU-982772:r:Growth hormone receptor signaling", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-RNO-77387:r:Insulin receptor recycling", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-110478:r:Insulin signaling pathway", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-DME-445144:r:Signal transduction by L1", "R-HSA-5683826:r:Surfactant metabolism", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-MMU-376172:r:DSCAM interactions", "R-HSA-5689603:r:UCH proteinases", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-GGA-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-376172:r:DSCAM interactions", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-6809371:r:Formation of the cornified envelope", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-MMU-419037:r:NCAM1 interactions", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000157:r:Laminin interactions", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-MMU-8948216:r:Collagen chain trimerization", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-416700:r:Other semaphorin interactions", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CEL-418885:r:DCC mediated attractive signaling", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-5689603:r:UCH proteinases", "R-RNO-373752:r:Netrin-1 signaling", "R-RNO-8932505:r:DAG1 core M3 glycosylations", "R-HSA-354192:r:Integrin signaling", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-210991:r:Basigin interactions", "R-DME-376172:r:DSCAM interactions", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-1566977:r:Fibronectin matrix formation", "R-DME-77387:r:Insulin receptor recycling", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-BTA-9020958:r:Interleukin-21 signaling", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-877300:r:Interferon gamma signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-DME-2022928:r:HS-GAG biosynthesis"], "type": "Domain"}, "IPR003963": {"description": "Bi-component toxin, staphylococci", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Bi-component_toxin_staph", "pathway_ids": ["R-HSA-9660826", "R-HSA-844456"], "pathways": ["R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Family"}, "IPR003964": {"description": "Carbamate kinase", "go_ids": ["GO:0006525", "GO:0008804"], "go_terms": ["GO:0006525:arginine metabolic process:P", "GO:0008804:carbamate kinase activity:F"], "name": "Carb_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR003966": {"description": "Prothrombin/thrombin", "go_ids": ["GO:0004252", "GO:0005509", "GO:0006508", "GO:0007596"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0005509:calcium ion binding:F", "GO:0006508:proteolysis:P", "GO:0007596:blood coagulation:P"], "name": "Prothrombin/thrombin", "pathway_ids": ["R-MMU-416476", "R-HSA-9657688", "R-HSA-159782", "R-MMU-159740", "R-HSA-375276", "R-MMU-76009", "R-HSA-140837", "R-RNO-159782", "R-RNO-140875", "R-HSA-416476", "R-MMU-375276", "R-RNO-977606", "R-RNO-140837", "R-HSA-76009", "R-MMU-456926", "R-HSA-977606", "R-RNO-202733", "R-MMU-202733", "R-MMU-159763", "R-HSA-9672391", "R-RNO-416476", "R-HSA-9918481", "R-RNO-159740", "R-HSA-381426", "R-HSA-159763", "R-MMU-977606", "R-HSA-456926", "R-RNO-159763", "R-MMU-140837", "R-HSA-140875", "R-MMU-140875", "R-RNO-381426", "R-HSA-159740", "R-RNO-456926", "R-RNO-375276", "R-MMU-159782", "R-HSA-202733"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR003973": {"description": "Potassium channel, voltage dependent, Kv2", "go_ids": ["GO:0005249", "GO:0006813", "GO:0008076"], "go_terms": ["GO:0005249:voltage-gated potassium channel activity:F", "GO:0006813:potassium ion transport:P", "GO:0008076:voltage-gated potassium channel complex:C"], "name": "K_chnl_volt-dep_Kv2", "pathway_ids": ["R-HSA-1296072", "R-BTA-1296072", "R-RNO-381676", "R-RNO-1296072", "R-HSA-381676", "R-MMU-381676", "R-MMU-1296072"], "pathways": ["R-HSA-1296072:r:Voltage gated Potassium channels", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-1296072:r:Voltage gated Potassium channels"], "type": "Family"}, "IPR003977": {"description": "E3 ubiquitin-protein ligase parkin", "go_ids": ["GO:0005829", "GO:0005739", "GO:0004842"], "go_terms": ["GO:0005829:cytosol:C", "GO:0005739:mitochondrion:C", "GO:0004842:ubiquitin-protein transferase activity:F"], "name": "Parkin", "pathway_ids": ["R-DME-983168", "R-HSA-9646399", "R-RNO-5205685", "R-HSA-5689877", "R-HSA-977225", "R-HSA-5675482", "R-DME-5689877", "R-MMU-5675482", "R-DME-9646399", "R-HSA-983168", "R-MMU-5205685", "R-MMU-9646399", "R-MMU-5689877", "R-DME-5205685", "R-RNO-5689877", "R-MMU-983168", "R-RNO-9646399", "R-RNO-5675482", "R-HSA-5205685", "R-RNO-983168"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9646399:r:Aggrephagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5689877:r:Josephin domain DUBs", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-DME-5689877:r:Josephin domain DUBs", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DME-9646399:r:Aggrephagy", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-9646399:r:Aggrephagy", "R-MMU-5689877:r:Josephin domain DUBs", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-5689877:r:Josephin domain DUBs", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR003978": {"description": "Thrombopoietin", "go_ids": ["GO:0005125", "GO:0005576", "GO:0008283"], "go_terms": ["GO:0005125:cytokine activity:F", "GO:0005576:extracellular region:C", "GO:0008283:cell population proliferation:P"], "name": "Thrombopoietin", "pathway_ids": ["R-HSA-76009"], "pathways": ["R-HSA-76009:r:Platelet Aggregation (Plug Formation)"], "type": "Family"}, "IPR003979": {"description": "Tropoelastin", "go_ids": ["GO:0005201", "GO:0031012"], "go_terms": ["GO:0005201:extracellular matrix structural constituent:F", "GO:0031012:extracellular matrix:C"], "name": "Tropoelastin", "pathway_ids": ["R-HSA-1474228", "R-HSA-2129379", "R-RNO-1566948", "R-RNO-1474228", "R-HSA-1566948", "R-MMU-1566948", "R-RNO-2129379", "R-MMU-2129379", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-RNO-1566948:r:Elastic fibre formation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-1566948:r:Elastic fibre formation", "R-MMU-1566948:r:Elastic fibre formation", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Family"}, "IPR003993": {"description": "Treacle protein domain", "go_ids": [], "go_terms": [], "name": "Treacle_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR003996": {"description": "RTX toxin-activating protein C, bacteria", "go_ids": ["GO:0005737", "GO:0016746", "GO:0009404"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0016746:acyltransferase activity:F", "GO:0009404:toxin metabolic process:P"], "name": "RTX_toxin-activating_protC_bac", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR004000": {"description": "Actin family", "go_ids": [], "go_terms": [], "name": "Actin", "pathway_ids": ["PWY-7250", "R-RNO-9013026", "R-MMU-8856828", "R-DME-190873", "R-SSC-3371497", "R-SSC-5689603", "R-HSA-6802952", "R-BTA-3928662", "R-BTA-9933946", "R-DME-5696394", "R-XTR-5696394", "R-CFA-3371497", "R-HSA-418990", "R-SSC-2132295", "R-BTA-4420097", "R-SCE-8980692", "R-HSA-9662360", "R-GGA-5663220", "R-GGA-9933937", "R-CFA-2132295", "R-MMU-5696394", "R-DME-446353", "R-HSA-6802955", "R-DME-5663213", "R-DDI-6798695", "R-MMU-9035034", "R-SPO-2029482", "R-MMU-9934037", "R-HSA-6802948", "R-MMU-380259", "R-GGA-445355", "R-HSA-437239", "R-CEL-5674135", "R-RNO-5663220", "R-GGA-9764561", "R-MMU-9933939", "R-BTA-6811436", "R-SSC-6807878", "R-DRE-9035034", "R-DRE-9953170", "R-BTA-8980692", "R-MMU-9013418", "R-HSA-389957", "R-DDI-9013418", "R-RNO-380270", "R-MMU-3371497", "R-DME-9933946", "R-SSC-6798695", "R-DRE-114608", "R-MMU-5674135", "R-HSA-190873", "R-DRE-3928662", "R-RNO-8980692", "R-CEL-9934037", "R-XTR-9013026", "R-DME-9934037", "R-SSC-5626467", "R-HSA-9934037", "R-SCE-5626467", "R-HSA-114608", "R-RNO-2565942", "R-MMU-2132295", "R-RNO-3928662", "R-RNO-8856828", "R-RNO-5674135", "R-GGA-9953170", "R-HSA-6811436", "R-RNO-9013418", "R-RNO-9933946", "R-HSA-196025", "R-CEL-8856828", "R-RNO-2132295", "R-SSC-9933937", "R-RNO-437239", "R-DME-6798695", "R-BTA-5696394", "R-RNO-5626467", "R-SSC-4420097", "R-MMU-3214858", "R-BTA-9934037", "R-CFA-5620912", "R-XTR-8980692", "R-HSA-3928665", "R-GGA-3928665", "R-HSA-446353", "R-HSA-3214847", "R-DRE-4420097", "R-HSA-9953170", "R-HSA-6798695", "R-DME-9933947", "R-SSC-196025", "R-SSC-5663220", "R-GGA-9035034", "R-CEL-5626467", "R-DRE-5674135", "R-DME-3371497", "R-HSA-8856828", "R-CEL-6798695", "R-BTA-6798695", "R-GGA-2029482", "R-MMU-4420097", "R-MMU-2565942", "R-CFA-380284", "R-RNO-380320", "R-BTA-9953170", "R-DME-2029482", "R-HSA-9764561", "R-DRE-5626467", "R-DRE-6798695", "R-DME-3928665", "R-SSC-9933947", "R-XTR-2029482", "R-DRE-418990", "R-CEL-3928662", "R-DME-6807878", "R-GGA-3928662", "R-GGA-8856828", "R-GGA-9933939", "R-MMU-5250924", "R-SSC-380259", "R-DME-437239", "R-HSA-9933947", "R-DME-3928662", "R-HSA-2029482", "R-CEL-5663213", "R-DRE-5696394", "R-SPO-8980692", "R-HSA-9013695", "R-HSA-8939243", "R-BTA-445355", "R-MMU-445095", "R-SCE-2029482", "R-MMU-8854518", "R-MMU-6798695", "R-BTA-3371497", "R-DME-9764561", "R-DDI-9953170", "R-GGA-9933946", "R-MMU-114608", "R-CEL-9933947", "R-XTR-9953170", "R-SPO-6798695", "R-SSC-380270", "R-HSA-2132295", "R-DRE-196025", "R-CEL-5663220", "R-CEL-190873", "R-GGA-4420097", "R-BTA-5663220", "R-MMU-6807878", "R-SSC-9933939", "R-BTA-9933937", "R-SPO-114608", "R-RNO-2029482", "R-RNO-114608", "R-HSA-2565942", "R-RNO-5663213", "R-BTA-5674135", "R-RNO-5689603", "R-CFA-2565942", "R-MMU-9764561", "R-HSA-9035034", "R-DME-5689603", "R-BTA-9933939", "R-CEL-9933946", "R-RNO-9933939", "R-SSC-2029482", "R-XTR-8856828", "R-DRE-5663213", "R-HSA-445355", "R-RNO-446353", "R-RNO-390522", "R-RNO-8854518", "R-GGA-418990", "R-GGA-5663213", "R-HSA-9927432", "R-BTA-9933947", "R-XTR-5663220", "R-SSC-446353", "R-HSA-9824585", "R-MMU-2029482", "R-XTR-9764561", "R-XTR-9934037", "R-BTA-5689603", "R-SSC-8856828", "R-CEL-4420097", "R-DDI-6807878", "R-SCE-5663213", "R-MMU-3928662", "R-HSA-390522", "R-HSA-5250924", "R-HSA-9933946", "R-HSA-9664422", "R-CEL-9933939", "R-HSA-380259", "R-XTR-5689603", "R-HSA-5663213", "R-GGA-5689603", "R-RNO-445095", "R-BTA-446353", "R-MMU-9933946", "R-HSA-9013418", "R-SCE-114608", "R-MMU-445355", "R-DDI-114608", "R-DME-445355", "R-GGA-9933947", "R-MMU-380320", "R-SSC-9764561", "R-DME-9933939", "R-MMU-5663213", "R-BTA-5663213", "R-BTA-5626467", "R-RNO-380284", "R-SSC-2565942", "R-BTA-5250924", "R-DRE-5663220", "R-MMU-5620912", "R-GGA-196025", "R-SPO-5626467", "R-XTR-446353", "R-SSC-8854518", "R-MMU-196025", "R-CEL-9933937", "R-DRE-9764561", "R-DME-114608", "R-DME-196025", "R-HSA-983231", "R-MMU-380270", "R-RNO-9934037", "R-SSC-3928662", "R-RNO-9933947", "R-RNO-5696394", "R-GGA-5674135", "R-RNO-6811436", "R-DRE-5689603", "R-BTA-9913351", "R-HSA-9933937", 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"R-HSA-4420097", "R-BTA-9035034", "R-DME-9035034", "R-HSA-380320", "R-GGA-437239", "R-SSC-5663213", "R-RNO-196025", "R-HSA-9649948", "R-BTA-9013418", "R-GGA-9934037", "R-DME-445095", "R-BTA-418990", "R-XTR-5663213", "R-SSC-418990", "R-DME-8980692", "R-HSA-390450", "R-SSC-9913351", "R-CEL-9764561", "R-MMU-390522", "R-CEL-114608", "R-RNO-9933937", "R-GGA-9013418", "R-CEL-446353", "R-GGA-6798695", "R-BTA-390522", "R-MMU-6811436", "R-SSC-380284", "R-HSA-8980692", "R-MMU-9913351", "R-DRE-446353", "R-HSA-5689603", "R-XTR-114608", "R-RNO-4420097", "R-SSC-9933946", "R-HSA-5626467", "R-MMU-9933937", "R-DRE-2029482", "R-CEL-437239", "R-RNO-418990", "R-SSC-114608", "R-RNO-5620912", "R-HSA-3214858", "R-BTA-3214858", "R-BTA-114608", "R-HSA-6802946", "R-HSA-9845323", "R-DME-9913351", "R-RNO-190873", "R-DME-8856828", "R-DME-9933937", "R-MMU-5689603", "R-HSA-5620912", "R-XTR-196025", "R-RNO-9953170", "R-CEL-9913351", "R-RNO-9764561", "R-RNO-6807878", "R-CEL-196025", "R-HSA-9662361", "R-HSA-6807878", 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complexes", "R-GGA-190873:r:Gap junction degradation", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SSC-9953170:r:GBP-mediated host defense", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-SCE-190873:r:Gap junction degradation", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-CFA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-196025:r:Formation of annular gap junctions", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-SSC-190873:r:Gap junction degradation", "R-XTR-5626467:r:RHO GTPases activate IQGAPs", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-SPO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-9035034:r:RHOF GTPase cycle", "R-BTA-190873:r:Gap junction degradation", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-9035034:r:RHOF GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-437239:r:Recycling pathway of L1", "R-SSC-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-196025:r:Formation of annular gap junctions", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-GGA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DME-445095:r:Interaction between L1 and Ankyrins", "R-BTA-418990:r:Adherens junctions interactions", "R-XTR-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-418990:r:Adherens junctions interactions", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-390450:r:Folding of actin by CCT/TriC", "R-SSC-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-MMU-390522:r:Striated Muscle Contraction", "R-CEL-114608:r:Platelet degranulation", "R-RNO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-GGA-9013418:r:RHOBTB2 GTPase cycle", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-390522:r:Striated Muscle Contraction", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DRE-446353:r:Cell-extracellular matrix interactions", "R-HSA-5689603:r:UCH proteinases", "R-XTR-114608:r:Platelet degranulation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-SSC-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DRE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-437239:r:Recycling pathway of L1", "R-RNO-418990:r:Adherens junctions interactions", "R-SSC-114608:r:Platelet degranulation", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-BTA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-190873:r:Gap junction degradation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-196025:r:Formation of annular gap junctions", "R-RNO-9953170:r:GBP-mediated host defense", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-9764561:r:Regulation of CDH1 Function", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-CEL-196025:r:Formation of annular gap junctions", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-9764561:r:Regulation of CDH1 Function", "R-XTR-9035034:r:RHOF GTPase cycle", "R-XTR-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-418990:r:Adherens junctions interactions", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-CFA-8854518:r:AURKA Activation by TPX2", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-PFA-114608:r:Platelet degranulation", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-9035034:r:RHOF GTPase cycle", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-9933947:r:Formation of the non-canonical BAF (ncBAF) complex"], "type": "Family"}, "IPR004005": {"description": "Calicivirus coat protein", "go_ids": [], "go_terms": [], "name": "Calicivirus_coat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004006": {"description": "DhaK domain", "go_ids": ["GO:0004371", "GO:0006071"], "go_terms": ["GO:0004371:glycerone kinase activity:F", "GO:0006071:glycerol metabolic process:P"], "name": "DhaK_dom", "pathway_ids": ["R-SCE-70350", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9692916", "R-SPO-70350", "R-HSA-70350", "R-RNO-70350", "R-DDI-70350", "R-MMU-70350"], "pathways": ["R-SCE-70350:r:Fructose catabolism", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-SPO-70350:r:Fructose catabolism", "R-HSA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-DDI-70350:r:Fructose catabolism", "R-MMU-70350:r:Fructose catabolism"], "type": "Domain"}, "IPR004007": {"description": "DhaL domain", "go_ids": ["GO:0004371", "GO:0006071"], "go_terms": ["GO:0004371:glycerone kinase activity:F", "GO:0006071:glycerol metabolic process:P"], "name": "DhaL_dom", "pathway_ids": ["R-SCE-70350", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9692916", "R-SPO-70350", "R-HSA-70350", "R-RNO-70350", "R-DDI-70350", "R-MMU-70350"], "pathways": ["R-SCE-70350:r:Fructose catabolism", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-SPO-70350:r:Fructose catabolism", "R-HSA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-DDI-70350:r:Fructose catabolism", "R-MMU-70350:r:Fructose catabolism"], "type": "Domain"}, "IPR004009": {"description": "Myosin, SH3 domain", "go_ids": ["GO:0003774", "GO:0005524", "GO:0016459"], "go_terms": ["GO:0003774:cytoskeletal motor activity:F", "GO:0005524:ATP binding:F", "GO:0016459:myosin complex:C"], "name": "SH3_Myosin", "pathway_ids": ["R-HSA-416572", "R-HSA-5625900", "R-DME-190873", "R-HSA-9013418", "R-HSA-9013422", "R-HSA-9662834", "R-HSA-190873", "R-HSA-264876", "R-SCE-5627123", "R-HSA-5625740", "R-MMU-445355", "R-DME-445355", "R-DDI-9013422", "R-BTA-5627123", "R-RNO-2029482", "R-MMU-9013422", "R-MMU-9013420", "R-MMU-190873", "R-HSA-9662360", "R-MMU-9824585", "R-HSA-432040", "R-SCE-9013425", "R-SCE-9013420", "R-SPO-9013420", "R-SCE-190873", "R-MMU-9013418", "R-HSA-5655302", "R-HSA-9013420", "R-HSA-399719", "R-RNO-390522", "R-HSA-445355", "R-SPO-9013419", "R-SPO-9013425", "R-HSA-9662361", "R-HSA-9927432", "R-MMU-390522", "R-RNO-9824585", "R-HSA-2029482", "R-DME-350480", "R-DME-9013422", "R-MMU-2029482", "R-GGA-9824585", "R-DME-9013418", "R-MMU-432040", "R-HSA-9824585", "R-HSA-9703465", "R-HSA-3928663", "R-HSA-5627123", "R-SPO-5627123", "R-SPO-190873", "R-HSA-1445148", "R-HSA-390522", "R-SCE-9013419", "R-DDI-5627123", "R-MMU-399719", "R-MMU-5627123", "R-RNO-432040", "R-HSA-9664422", "R-HSA-9725370", "R-DDI-9013418", "R-DME-9013420", "R-HSA-5627117", "R-HSA-1839117"], "pathways": ["R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-DME-190873:r:Gap junction degradation", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-190873:r:Gap junction degradation", "R-HSA-264876:r:Insulin processing", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-MMU-190873:r:Gap junction degradation", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013420:r:RHOU GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-SCE-190873:r:Gap junction degradation", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-MMU-390522:r:Striated Muscle Contraction", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-SPO-190873:r:Gap junction degradation", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-390522:r:Striated Muscle Contraction", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DME-9013420:r:RHOU GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR004010": {"description": "Double Cache domain 2", "go_ids": [], "go_terms": [], "name": "Double_Cache_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004011": {"description": "GYR motif", "go_ids": [], "go_terms": [], "name": "Gyr_motif", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR004012": {"description": "RUN domain", "go_ids": [], "go_terms": [], "name": "Run_dom", "pathway_ids": ["R-RNO-8876198", "R-HSA-8876198", "R-MMU-8876198", "R-HSA-1660499", "R-MMU-1660499"], "pathways": ["R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Domain"}, "IPR004013": {"description": "PHP domain", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "PHP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004014": {"description": "Cation-transporting P-type ATPase, N-terminal", "go_ids": [], "go_terms": [], "name": "ATPase_P-typ_cation-transptr_N", "pathway_ids": ["R-GGA-936837", "R-DME-418359", "R-DDI-5578775", "R-BTA-936837", "R-SSC-936837", "R-CFA-936837", "R-MMU-418359", "R-HSA-9662360", "R-BTA-5578775", "R-CFA-5578775", "R-HSA-5578775", "R-MMU-936837", "R-CFA-418359", "R-SPO-5578775", "R-DDI-418359", "R-CEL-936837", "R-SCE-418359", "R-DDI-936837", "R-HSA-418359", "R-HSA-1912420", "R-CEL-418359", "R-GGA-418359", "R-DME-936837", "R-GGA-5578775", "R-DME-5578775", "R-RNO-5578775", "R-HSA-9662361", "R-RNO-418359", "R-SPO-418359", "R-MMU-5578775", "R-SPO-936837", "R-HSA-936837", "R-HSA-9679191", "R-SSC-5578775", "R-RNO-936837", "R-SCE-936837", "R-SCE-5578775", "R-CEL-5578775", "R-SSC-418359", "R-BTA-418359"], "pathways": ["R-GGA-936837:r:Ion transport by P-type ATPases", "R-DME-418359:r:Reduction of cytosolic Ca++ levels", "R-DDI-5578775:r:Ion homeostasis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-SSC-936837:r:Ion transport by P-type ATPases", "R-CFA-936837:r:Ion transport by P-type ATPases", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-5578775:r:Ion homeostasis", "R-CFA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CFA-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-5578775:r:Ion homeostasis", "R-DDI-418359:r:Reduction of cytosolic Ca++ levels", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-SCE-418359:r:Reduction of cytosolic Ca++ levels", "R-DDI-936837:r:Ion transport by P-type ATPases", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-CEL-418359:r:Reduction of cytosolic Ca++ levels", "R-GGA-418359:r:Reduction of cytosolic Ca++ levels", "R-DME-936837:r:Ion transport by P-type ATPases", "R-GGA-5578775:r:Ion homeostasis", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-5578775:r:Ion homeostasis", "R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SSC-5578775:r:Ion homeostasis", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases", "R-SCE-5578775:r:Ion homeostasis", "R-CEL-5578775:r:Ion homeostasis", "R-SSC-418359:r:Reduction of cytosolic Ca++ levels", "R-BTA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Domain"}, "IPR004015": {"description": "SKI-interacting protein SKIP, SNW domain", "go_ids": ["GO:0000398", "GO:0005681"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P", "GO:0005681:spliceosomal complex:C"], "name": "SKI-int_prot_SKIP_SNW-dom", "pathway_ids": ["R-MMU-2173795", "R-CEL-2173795", "R-DME-350054", "R-HSA-9013508", "R-HSA-8941856", "R-HSA-210744", "R-MMU-72163", "R-MMU-2122947", "R-HSA-2894862", "R-DME-72163", "R-DME-2173795", "R-DDI-72163", "R-BTA-8941856", "R-HSA-350054", "R-BTA-350054", "R-HSA-1912408", "R-HSA-72163", "R-HSA-9013695", "R-MMU-350054", "R-HSA-2173795", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-BTA-2173795", "R-CEL-72163", "R-SPO-72163", "R-HSA-2122947", "R-HSA-9918481", "R-BTA-72163"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-350054:r:Notch-HLH transcription pathway", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-BTA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR004017": {"description": "Cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "Cys_rich_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004018": {"description": "RPEL repeat", "go_ids": [], "go_terms": [], "name": "RPEL_repeat", "pathway_ids": ["R-HSA-114608", "R-HSA-5663220", "R-HSA-9733709", "R-HSA-3899300", "R-MMU-3899300", "R-MMU-5663220", "R-RNO-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-114608:r:Platelet degranulation"], "type": "Repeat"}, "IPR004019": {"description": "YLP motif", "go_ids": [], "go_terms": [], "name": "YLP_motif", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR004020": {"description": "DAPIN domain", "go_ids": [], "go_terms": [], "name": "DAPIN", "pathway_ids": ["R-HSA-6798695", "R-HSA-5689901", "R-HSA-1606341", "R-DRE-844455", "R-HSA-9705671", "R-DRE-9960525", "R-MMU-1834949", "R-HSA-1834941", "R-MMU-5689901", "R-DRE-111458", "R-DRE-9960519", "R-RNO-5689901", "R-DRE-9627069", "R-HSA-5660668", "R-MMU-844615", "R-DRE-6798695", "R-HSA-9707564", "R-HSA-1834949", "R-HSA-844455", "R-BTA-5689901", "R-MMU-5660668", "R-DRE-9948011", "R-HSA-3270619", "R-MMU-3270619", "R-HSA-9660826", "R-MMU-3134975", "R-RNO-844456", "R-MMU-844456", "R-BTA-844456", "R-DRE-844456", "R-HSA-9692916", "R-HSA-3134975", "R-DRE-9948001", "R-MMU-6798695", "R-HSA-844615", "R-HSA-844456"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-DRE-844455:r:The NLRP1 inflammasome", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DRE-9960525:r:CASP5-mediated substrate cleavage", "R-MMU-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-MMU-5689901:r:Metalloprotease DUBs", "R-DRE-111458:r:Formation of apoptosome", "R-DRE-9960519:r:CASP4-mediated substrate cleavage", "R-RNO-5689901:r:Metalloprotease DUBs", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-844615:r:The AIM2 inflammasome", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-844455:r:The NLRP1 inflammasome", "R-BTA-5689901:r:Metalloprotease DUBs", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-DRE-9948011:r:CASP5 inflammasome assembly", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-BTA-844456:r:The NLRP3 inflammasome", "R-DRE-844456:r:The NLRP3 inflammasome", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DRE-9948001:r:CASP4 inflammasome assembly", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-844615:r:The AIM2 inflammasome", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Domain"}, "IPR004021": {"description": "HIN-200/IF120x", "go_ids": [], "go_terms": [], "name": "HIN200/IF120x", "pathway_ids": ["R-HSA-1834949", "R-MMU-6798695", "R-HSA-6798695", "R-HSA-3270619", "R-HSA-844615", "R-MMU-844615", "R-MMU-1834949", "R-HSA-1834941"], "pathways": ["R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-844615:r:The AIM2 inflammasome", "R-MMU-844615:r:The AIM2 inflammasome", "R-MMU-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-1834941:r:STING mediated induction of host immune responses"], "type": "Domain"}, "IPR004023": {"description": "Mago nashi protein", "go_ids": ["GO:0008380", "GO:0035145"], "go_terms": ["GO:0008380:RNA splicing:P", "GO:0035145:exon-exon junction complex:C"], "name": "Mago_nashi", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-HSA-73856", "R-DME-159236", "R-DME-72163", "R-RNO-72163", "R-SPO-975957", "R-CEL-73856", "R-HSA-72187", "R-DDI-72163", "R-RNO-73856", "R-DRE-159236", "R-DRE-72163", "R-DRE-73856", "R-RNO-159236", "R-DME-73856", "R-CEL-72163", "R-BTA-72163", "R-RNO-975957", "R-SPO-159236", "R-MMU-72163", "R-MMU-975957", "R-MMU-73856", "R-BTA-73856", "R-DRE-975957", "R-MMU-159236", "R-HSA-72163", "R-HSA-975957", "R-MMU-72187", "R-BTA-159236", "R-HSA-159236", "R-DDI-975957", "R-SPO-72163", "R-DME-975957", "R-CEL-159236"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR004026": {"description": "Ada DNA repair, metal-binding", "go_ids": ["GO:0003677", "GO:0006281", "GO:0006355", "GO:0008168", "GO:0008270"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006281:DNA repair:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0008168:methyltransferase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Ada_DNA_repair_Zn-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004027": {"description": "SEC-C motif", "go_ids": [], "go_terms": [], "name": "SEC_C_motif", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Conserved_site"}, "IPR004028": {"description": "Retroviral Gag polyprotein, M", "go_ids": [], "go_terms": [], "name": "Gag_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004029": {"description": "UreE urease accessory, N-terminal", "go_ids": [], "go_terms": [], "name": "UreE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004030": {"description": "Nitric oxide synthase, N-terminal", "go_ids": ["GO:0004517", "GO:0006809"], "go_terms": ["GO:0004517:nitric-oxide synthase activity:F", "GO:0006809:nitric oxide biosynthetic process:P"], "name": "NOS_N", "pathway_ids": ["PWY-4983", "R-MMU-1222556", "R-SSC-9033241", "R-MMU-9856530", "R-HSA-1474151", "R-HSA-392154", "R-DME-1222556", "R-RNO-9009391", "R-MMU-203615", "R-MMU-9009391", "R-MMU-203641", "R-RNO-1222556", "R-RNO-392154", "R-RNO-5218920", "R-HSA-203615", "R-RNO-9033241", "R-HSA-5218920", "R-HSA-1222556", "R-RNO-1474151", "R-MMU-392154", "R-DME-9009391", "R-HSA-5578775", "R-RNO-203641", "R-HSA-203641", "R-RNO-203754", "R-SSC-1222556", "R-HSA-9636249", "R-MMU-5218920", "R-DME-392154", "R-DME-5578775", "R-RNO-5578775", "R-DME-9033241", "R-MMU-5578775", "R-MMU-9033241", "R-HSA-6785807", "R-SSC-392154", "R-DME-203615", "R-MMU-1474151", "R-RNO-203615", "R-DME-5218920", "R-RNO-9856530", "R-HSA-203754", "R-HSA-9009391", "R-MMU-203754", "R-DME-203754", "R-DME-1474151", "R-HSA-9856530", "R-HSA-9033241", "R-DME-9856530"], "pathways": ["PWY-4983:t:nitric oxide biosynthesis II (mammals)", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-9033241:r:Peroxisomal protein import", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203615:r:eNOS activation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-203615:r:eNOS activation", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-203754:r:NOSIP mediated eNOS trafficking", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-DME-9033241:r:Peroxisomal protein import", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-203615:r:eNOS activation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-DME-203754:r:NOSIP mediated eNOS trafficking", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Domain"}, "IPR004031": {"description": "PMP-22/EMP/MP20/Claudin", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "PMP22/EMP/MP20/Claudin", "pathway_ids": ["R-RNO-5576893", "R-HSA-6809371", "R-HSA-420029", "R-RNO-112308", "R-BTA-5682910", "R-HSA-9918485", "R-MMU-5576892", "R-HSA-9619665", "R-HSA-9856532", "R-HSA-6803205", "R-HSA-5576892", "R-HSA-5576893", "R-MMU-5576893", "R-MMU-112308", "R-RNO-5576892", "R-HSA-9925563", "R-RNO-5682910", "R-HSA-399719", "R-DRE-6809371", "R-RNO-399719", "R-HSA-8935964", "R-MMU-6809371", "R-MMU-5682910", "R-BTA-399719", "R-HSA-5682910", "R-HSA-112308", "R-MMU-399719"], "pathways": ["R-RNO-5576893:r:Phase 2 - plateau phase", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-420029:r:Tight junction interactions", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-BTA-5682910:r:LGI-ADAM interactions", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-5682910:r:LGI-ADAM interactions", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-DRE-6809371:r:Formation of the cornified envelope", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-5682910:r:LGI-ADAM interactions", "R-BTA-399719:r:Trafficking of AMPA receptors", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-399719:r:Trafficking of AMPA receptors"], "type": "Family"}, "IPR004033": {"description": "UbiE/COQ5 methyltransferase", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "UbiE/COQ5_MeTrFase", "pathway_ids": ["PWY-5870", "PWY-5873", "PWY-5871", "PWY-5895", "PWY-5849", "PWY-5856", "PWY-6708", "PWY-5857", "PWY-5839", "PWY-5891", "PWY-5892", "PWY-5844", "PWY-7230", "PWY-5872", "PWY-5855", "PWY-5890", "PWY-7996", "R-DRE-2142789", "R-SPO-2142789", "R-SCE-2142789", "R-MMU-2142789", "R-DDI-2142789", "R-HSA-2142789", "R-BTA-2142789", "R-RNO-2142789", "R-CEL-2142789", "R-DME-2142789"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-5895:t:menaquinol-13 biosynthesis", "PWY-5849:t:menaquinol-6 biosynthesis", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-5839:t:menaquinol-7 biosynthesis", "PWY-5891:t:menaquinol-11 biosynthesis", "PWY-5892:t:menaquinol-12 biosynthesis", "PWY-5844:t:menaquinol-9 biosynthesis", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)", "PWY-5890:t:menaquinol-10 biosynthesis", "PWY-7996:t:menaquinol-4 biosynthesis I", "R-DRE-2142789:r:Ubiquinol biosynthesis", "R-SPO-2142789:r:Ubiquinol 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"R-RNO-72649", "R-RNO-6791226", "R-SSC-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-SSC-72689", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-MMU-5389840", "R-SPO-72689", "R-CEL-72689", "R-CFA-9954714", "R-DDI-72689", "R-DDI-72702", "R-MMU-1799339", "R-SPO-72702", "R-HSA-9954716", "R-DDI-975956", "R-CFA-975957", "R-DME-156827", "R-MMU-9937383", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-SSC-72695", "R-BTA-5389840", "R-SSC-9954716", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-DRE-9937383", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-SSC-72702", "R-CFA-72689", "R-SCE-72689", "R-SCE-72695", "R-DRE-5419276", "R-MMU-72695", "R-MMU-975956", "R-RNO-5389840", "R-CFA-9954716", "R-SCE-156827", "R-DME-975957", "R-DME-72695", "R-MMU-72702", "R-DME-975956", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", 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"R-HSA-9912481", "R-CEL-9859138", "R-SPO-204174", "R-DDI-499943", "R-BTA-70895", "R-HSA-3299685", "R-CEL-9837999"], "pathways": ["R-CEL-6783984:r:Glycine degradation", "R-CEL-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-CEL-5362517:r:Signaling by Retinoic Acid", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9907570:r:Loss-of-function mutations in DLD cause MSUD3/DLDD", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-204174:r:Regulation of pyruvate 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from 2-OG", "R-CEL-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-HSA-1222541:r:Cell redox homeostasis", "R-DDI-6783984:r:Glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9853506:r:OGDH complex 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2-OG", "R-DME-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-RNO-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SCE-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-6783984:r:Glycine degradation", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-PFA-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-BTA-5362517:r:Signaling by Retinoic Acid", "R-HSA-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-BTA-6783984:r:Glycine degradation", "R-BTA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-CEL-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-CEL-9837999:r:Mitochondrial protein degradation"], "type": "Domain"}, "IPR004100": {"description": "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain", "go_ids": ["GO:1902600", "GO:0046034"], "go_terms": ["GO:1902600:proton transmembrane transport:P", "GO:0046034:ATP metabolic process:P"], "name": "ATPase_F1/V1/A1_a/bsu_N", "pathway_ids": ["PWY-7980", "R-MMU-1222556", "R-CEL-1222556", "R-HSA-2151201", "R-DDI-77387", "R-DME-1222556", "R-HSA-77387", "R-CFA-1268020", "R-MMU-9639288", "R-SPO-9639288", "R-HSA-9639288", "R-CFA-8949613", "R-RNO-983712", "R-HSA-1268020", "R-SPO-917977", "R-MMU-1268020", "R-CEL-9639288", "R-SPO-1222556", "R-RNO-917977", "R-CFA-9837999", "R-SSC-163210", "R-SCE-1222556", "R-SCE-917977", "R-MMU-77387", "R-BTA-1222556", "R-SCE-77387", "R-CEL-9837999", "R-SSC-8949613", "R-MMU-163210", "R-RNO-77387", "R-HSA-8949613", "R-HSA-163210", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-RNO-9639288", "R-HSA-917977", "R-CEL-1268020", "R-RNO-8949613", "R-DDI-983712", "R-BTA-77387", "R-DME-1268020", "R-DDI-917977", "R-MMU-9837999", "R-SCE-9639288", "R-CEL-163210", "R-HSA-9857377", "R-RNO-1222556", "R-DME-8949613", "R-PFA-917977", "R-HSA-1222556", "R-DDI-1222556", "R-HSA-9837999", "R-RNO-163210", "R-MMU-8949613", "R-RNO-1268020", "R-DDI-9837999", "R-DDI-9639288", "R-DDI-1268020", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-DME-9837999", "R-DME-163210", "R-CEL-8949613", "R-RNO-9837999", "R-CFA-163210", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-PFA-1222556", "R-CEL-983712", "R-SPO-9837999", "R-SCE-9837999", "R-CEL-917977", "R-SSC-9837999", "R-MMU-983712", "R-PFA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["PWY-7980:t:ATP biosynthesis", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DDI-77387:r:Insulin receptor recycling", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-CFA-1268020:r:Mitochondrial protein import", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-CFA-8949613:r:Cristae formation", "R-RNO-983712:r:Ion channel transport", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-MMU-1268020:r:Mitochondrial protein import", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-CFA-9837999:r:Mitochondrial protein degradation", "R-SSC-163210:r:Formation of ATP by chemiosmotic coupling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-MMU-77387:r:Insulin receptor recycling", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-SCE-77387:r:Insulin receptor recycling", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SSC-8949613:r:Cristae formation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-77387:r:Insulin receptor recycling", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-CEL-1268020:r:Mitochondrial protein import", "R-RNO-8949613:r:Cristae formation", "R-DDI-983712:r:Ion channel transport", "R-BTA-77387:r:Insulin receptor recycling", "R-DME-1268020:r:Mitochondrial protein import", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-DME-8949613:r:Cristae formation", "R-PFA-917977:r:Transferrin endocytosis and recycling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-8949613:r:Cristae formation", "R-RNO-1268020:r:Mitochondrial protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-1268020:r:Mitochondrial protein import", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-CFA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-PFA-1222556:r:ROS and RNS production in phagocytes", "R-CEL-983712:r:Ion channel transport", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-MMU-983712:r:Ion channel transport", "R-PFA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR004101": {"description": "Mur ligase, C-terminal", "go_ids": ["GO:0009058", "GO:0016881"], "go_terms": ["GO:0009058:biosynthetic process:P", "GO:0016881:acid-amino acid ligase activity:F"], "name": "Mur_ligase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004102": {"description": "Poly(ADP-ribose) polymerase, regulatory domain", "go_ids": ["GO:0003950"], "go_terms": ["GO:0003950:NAD+ poly-ADP-ribosyltransferase activity:F"], "name": "Poly(ADP-ribose)pol_reg_dom", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-MMU-2173795", "R-HSA-3108214", "R-HSA-192814", "R-DRE-5696400", "R-RNO-5685939", "R-RNO-110362", "R-RNO-3108214", "R-DRE-5685939", "R-DRE-110362", "R-DME-5696394", "R-DRE-5696395", "R-DRE-3108214", "R-MMU-5696395", "R-RNO-2173795", "R-MMU-110362", "R-HSA-2173795", "R-MMU-5685939", "R-MMU-5696394", "R-CEL-5696394", "R-MMU-5696400", "R-HSA-9683610", "R-RNO-5696395", "R-HSA-110362", "R-HSA-196807", "R-DME-5696395", "R-HSA-5685939", "R-DRE-5696394", "R-RNO-5696394", "R-HSA-9694631", "R-DME-5696400", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-5696394", "R-RNO-5696400", "R-HSA-5696400", "R-MMU-3108214"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-192814:r:vRNA Synthesis", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-196807:r:Nicotinate metabolism", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-DME-5696400:r:Dual Incision in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Domain"}, "IPR004103": {"description": "Polysaccharide lyase family 8, C-terminal", "go_ids": ["GO:0005576", "GO:0016829"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0016829:lyase activity:F"], "name": "Lyase_8_C", "pathway_ids": ["PWY-7645"], "pathways": ["PWY-7645:t:hyaluronan degradation"], "type": "Domain"}, "IPR004104": {"description": "Gfo/Idh/MocA-like oxidoreductase, C-terminal", "go_ids": [], "go_terms": [], "name": "Gfo/Idh/MocA-like_OxRdtase_C", "pathway_ids": ["PWY-7237", "PWY-5940", "PWY-7241"], "pathways": ["PWY-7237:t:myo-, chiro- and scyllo-inositol degradation", "PWY-5940:t:streptomycin biosynthesis", "PWY-7241:t:myo-inositol degradation II"], "type": "Domain"}, "IPR004105": {"description": "Histidine kinase CheA-like, homodimeric domain", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004673", "GO:0005737", "GO:0006935"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F", "GO:0005737:cytoplasm:C", "GO:0006935:chemotaxis:P"], "name": "CheA-like_dim", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004106": {"description": "Peptidase S9, N-terminal domain superfamily", "go_ids": ["GO:0004252", "GO:0006508"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_S9_N_sf", "pathway_ids": ["R-HSA-6798695", "R-RNO-72764", "R-SCE-6791226", "R-BTA-72764", "R-MMU-6798695", "R-BTA-6798695", "R-HSA-72764", "R-RNO-6798695", "R-MMU-72764"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-72764:r:Eukaryotic Translation Termination", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-72764:r:Eukaryotic Translation Termination", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-72764:r:Eukaryotic Translation Termination"], "type": "Homologous_superfamily"}, "IPR004107": {"description": "Integrase, SAM-like, N-terminal", "go_ids": ["GO:0003677", "GO:0015074"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0015074:DNA integration:P"], "name": "Integrase_SAM-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004108": {"description": "Iron hydrogenase, large subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "Fe_hydrogenase_lsu_C", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Domain"}, "IPR004109": {"description": "Hepatitis C virus, NS3 protease", "go_ids": ["GO:0006508", "GO:0008236", "GO:0019087"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008236:serine-type peptidase activity:F", "GO:0019087:symbiont-mediated transformation of host cell:P"], "name": "HepC_NS3_protease", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR004111": {"description": "Tetracycline repressor TetR, C-terminal", "go_ids": ["GO:0045892"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "Repressor_TetR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004113": {"description": "FAD-binding oxidoreductase/transferase, type 4, C-terminal", "go_ids": ["GO:0003824", "GO:0050660"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "FAD-bd_oxidored_4_C", "pathway_ids": ["R-MMU-9837999", "R-DRE-880009", "R-DRE-1268020", "R-DME-9033241", "R-CEL-75896", "R-RNO-75896", "R-MMU-9033241", "R-SCE-880009", "R-MMU-75896", "R-DRE-9837999", "R-SPO-880009", "R-RNO-9033241", "R-HSA-880009", "R-MMU-880009", "R-HSA-1268020", "R-HSA-75896", "R-SCE-9837999", "R-BTA-880009", "R-MMU-1268020", "R-HSA-9837999", "R-HSA-9033500", "R-HSA-9033241", "R-RNO-880009", "R-DME-75896"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-DRE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DRE-1268020:r:Mitochondrial protein import", "R-DME-9033241:r:Peroxisomal protein import", "R-CEL-75896:r:Plasmalogen biosynthesis", "R-RNO-75896:r:Plasmalogen biosynthesis", "R-MMU-9033241:r:Peroxisomal protein import", "R-SCE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-75896:r:Plasmalogen biosynthesis", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-SPO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-75896:r:Plasmalogen biosynthesis", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DME-75896:r:Plasmalogen biosynthesis"], "type": "Domain"}, "IPR004114": {"description": "THUMP domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "THUMP_dom", "pathway_ids": ["R-HSA-6790901"], "pathways": ["R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR004115": {"description": "GAD-like domain superfamily", "go_ids": ["GO:0004812", "GO:0005524", "GO:0005737"], "go_terms": ["GO:0004812:aminoacyl-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C"], "name": "GAD-like_sf", "pathway_ids": ["R-HSA-379726"], "pathways": ["R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR004116": {"description": "Amelogenin", "go_ids": ["GO:0031012", "GO:0007275"], "go_terms": ["GO:0031012:extracellular matrix:C", "GO:0007275:multicellular organism development:P"], "name": "Amelogenin", "pathway_ids": ["R-BTA-8957275", "R-RNO-381426", "R-SSC-381426", "R-SSC-8957275", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR004117": {"description": "Olfactory receptor, insect", "go_ids": ["GO:0004984", "GO:0005549", "GO:0007608", "GO:0016020"], "go_terms": ["GO:0004984:olfactory receptor activity:F", "GO:0005549:odorant binding:F", "GO:0007608:sensory perception of smell:P", "GO:0016020:membrane:C"], "name": "7tm6_olfct_rcpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004118": {"description": "Hepatitis TT virus, Orf2/Gyrovirus Vp2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HEV_TT_vir_Orf2/Gyrovir_Vp2_N", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Domain"}, "IPR004119": {"description": "Ecdysteroid kinase-like", "go_ids": [], "go_terms": [], "name": "EcKL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004120": {"description": "HTLV Tax", "go_ids": ["GO:0045893"], "go_terms": ["GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "Tax", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004121": {"description": "Human herpesvirus K1 glycoprotein, C-terminal", "go_ids": [], "go_terms": [], "name": "K1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004122": {"description": "Barrier- to-autointegration factor, BAF", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "BAF_prot", "pathway_ids": ["R-HSA-180910", "R-HSA-162592", "R-HSA-2980766", "R-BTA-2995383", "R-HSA-177539", "R-MMU-2980766", "R-RNO-2995383", "R-DME-2995383", "R-BTA-2980766", "R-CEL-2995383", "R-HSA-175567", "R-DRE-2995383", "R-HSA-2995383", "R-RNO-2980766", "R-MMU-2995383", "R-HSA-180689", "R-HSA-164843"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-BTA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-2980766:r:Nuclear Envelope Breakdown", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-DRE-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-2980766:r:Nuclear Envelope Breakdown", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation"], "type": "Family"}, "IPR004123": {"description": "Dim1 family", "go_ids": ["GO:0046540", "GO:0000398"], "go_terms": ["GO:0046540:U4/U6 x U5 tri-snRNP complex:C", "GO:0000398:mRNA splicing, via spliceosome:P"], "name": "Dim1", "pathway_ids": ["R-HSA-72163", "R-HSA-72165", "R-MMU-72165", "R-HSA-9918481", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR004124": {"description": "Glycoside hydrolase, family 33, N-terminal", "go_ids": ["GO:0004308", "GO:0005975"], "go_terms": ["GO:0004308:exo-alpha-sialidase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_33_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004125": {"description": "Signal recognition particle, SRP54 subunit, M-domain", "go_ids": ["GO:0006614", "GO:0008312", "GO:0048500"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P", "GO:0008312:7S RNA binding:F", "GO:0048500:signal recognition particle:C"], "name": "Signal_recog_particle_SRP54_M", "pathway_ids": ["R-HSA-1799339", "R-DRE-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-RNO-1799339", "R-BTA-1799339", "R-MMU-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Domain"}, "IPR004126": {"description": "Phospholipase A2 inhibitor, N-terminal domain", "go_ids": ["GO:0004859", "GO:0005576"], "go_terms": ["GO:0004859:phospholipase inhibitor activity:F", "GO:0005576:extracellular region:C"], "name": "PLipase_A2_inh_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004127": {"description": "Prefoldin alpha-like", "go_ids": [], "go_terms": [], "name": "Prefoldin_subunit_alpha", "pathway_ids": ["R-HSA-8953750", "R-HSA-389957"], "pathways": ["R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-389957:r:Prefoldin mediated transfer of substrate to CCT/TriC"], "type": "Family"}, "IPR004130": {"description": "GPN-loop GTPase", "go_ids": [], "go_terms": [], "name": "Gpn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004131": {"description": "Pyrophosphate-energised proton pump", "go_ids": ["GO:0004427", "GO:0009678", "GO:1902600", "GO:0016020"], "go_terms": ["GO:0004427:inorganic diphosphate phosphatase activity:F", "GO:0009678:diphosphate hydrolysis-driven proton transmembrane transporter activity:F", "GO:1902600:proton transmembrane transport:P", "GO:0016020:membrane:C"], "name": "PPase-energised_H-pump", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004132": {"description": "Kinetoplastid membrane protein 11", "go_ids": ["GO:0006952", "GO:0008284"], "go_terms": ["GO:0006952:defense response:P", "GO:0008284:positive regulation of cell population proliferation:P"], "name": "KMP11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004133": {"description": "DAN", "go_ids": [], "go_terms": [], "name": "DAN_dom", "pathway_ids": ["R-HSA-9830674", "R-HSA-1181150", "R-XTR-201451", "R-GGA-201451", "R-MMU-201451", "R-HSA-201451", "R-HSA-9937080", "R-HSA-1433617"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-1181150:r:Signaling by NODAL", "R-XTR-201451:r:Signaling by BMP", "R-GGA-201451:r:Signaling by BMP", "R-MMU-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-1433617:r:Regulation of signaling by NODAL"], "type": "Domain"}, "IPR004134": {"description": "Peptidase C1B, bleomycin hydrolase", "go_ids": ["GO:0006508", "GO:0070005"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0070005:cysteine-type aminopeptidase activity:F"], "name": "Peptidase_C1B", "pathway_ids": ["R-GGA-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-983168"], "pathways": ["R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR004137": {"description": "Hydroxylamine reductase/Ni-containing CO dehydrogenase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "HCP/CODH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004138": {"description": "Early phosphoprotein p84/Protein U79/U80", "go_ids": [], "go_terms": [], "name": "U79_p84", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR004139": {"description": "Glycosyl transferase, family 13", "go_ids": ["GO:0009101", "GO:0008375"], "go_terms": ["GO:0009101:glycoprotein biosynthetic process:P", "GO:0008375:acetylglucosaminyltransferase activity:F"], "name": "Glyco_trans_13", "pathway_ids": ["R-CEL-964739", "R-HSA-9683686", "R-HSA-8932506", "R-RNO-8932506", "R-MMU-8932504", "R-RNO-964739", "R-HSA-9694548", "R-MMU-9939291", "R-HSA-8932504", "R-RNO-8932504", "R-HSA-9939291", "R-HSA-964739", "R-HSA-5083628", "R-RNO-9939291", "R-MMU-964739", "R-MMU-8932506"], "pathways": ["R-CEL-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-RNO-8932506:r:DAG1 core M1 glycosylations", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-RNO-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-HSA-9694548:r:Maturation of spike protein", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-RNO-8932504:r:DAG1 core M2 glycosylations", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-HSA-5083628:r:Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "R-RNO-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-MMU-8932506:r:DAG1 core M1 glycosylations"], "type": "Family"}, "IPR004140": {"description": "Exocyst complex component Exo70", "go_ids": ["GO:0000145", "GO:0006887"], "go_terms": ["GO:0000145:exocyst:C", "GO:0006887:exocytosis:P"], "name": "Exo70", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Family"}, "IPR004142": {"description": "NDRG", "go_ids": [], "go_terms": [], "name": "NDRG", "pathway_ids": ["R-HSA-6803205"], "pathways": ["R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "type": "Family"}, "IPR004143": {"description": "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain", "go_ids": ["GO:0036211"], "go_terms": ["GO:0036211:protein modification process:P"], "name": "BPL_LPL_catalytic", "pathway_ids": ["PWY-7382", "PWY-6987", "R-SPO-9857492", "R-SPO-196780", "R-PFA-9857492", "R-DME-9857492", "R-MMU-9857492", "R-XTR-9857492", "R-DRE-9857492", "R-HSA-196780", "R-SCE-9857492", "R-BTA-9857492", "R-SCE-196780", "R-HSA-3371599", "R-MMU-196780", "R-HSA-9857492"], "pathways": ["PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-6987:t:lipoate biosynthesis and incorporation III (Bacillus)", "R-SPO-9857492:r:Protein lipoylation", "R-SPO-196780:r:Biotin transport and metabolism", "R-PFA-9857492:r:Protein lipoylation", "R-DME-9857492:r:Protein lipoylation", "R-MMU-9857492:r:Protein lipoylation", "R-XTR-9857492:r:Protein lipoylation", "R-DRE-9857492:r:Protein lipoylation", "R-HSA-196780:r:Biotin transport and metabolism", "R-SCE-9857492:r:Protein lipoylation", "R-BTA-9857492:r:Protein lipoylation", "R-SCE-196780:r:Biotin transport and metabolism", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-9857492:r:Protein lipoylation"], "type": "Domain"}, "IPR004145": {"description": "Domain of unknown function DUF243", "go_ids": [], "go_terms": [], "name": "DUF243", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004146": {"description": "DC1", "go_ids": [], "go_terms": [], "name": "DC1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004147": {"description": "ABC1 atypical kinase-like domain", "go_ids": [], "go_terms": [], "name": "ABC1_dom", "pathway_ids": ["R-DRE-2142789", "R-SCE-2142789", "R-SPO-2142789", "R-MMU-2142789", "R-DDI-2142789", "R-HSA-2142789", "R-BTA-2142789", "R-RNO-2142789", "R-CEL-2142789"], "pathways": ["R-DRE-2142789:r:Ubiquinol biosynthesis", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-BTA-2142789:r:Ubiquinol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-CEL-2142789:r:Ubiquinol biosynthesis"], "type": "Domain"}, "IPR004148": {"description": "BAR domain", "go_ids": ["GO:0005515", "GO:0005737"], "go_terms": ["GO:0005515:protein binding:F", "GO:0005737:cytoplasm:C"], "name": "BAR_dom", "pathway_ids": ["R-RNO-9013026", "R-XTR-9013106", "R-HSA-9013409", "R-MMU-8856828", "R-HSA-9013405", "R-MMU-182971", "R-SPO-5689901", "R-HSA-6798695", "R-GGA-9013026", "R-RNO-9013409", "R-HSA-8856828", "R-MMU-9013106", "R-MMU-9013408", "R-CEL-432722", "R-RNO-9013149", "R-MMU-9013409", "R-MMU-9013404", "R-MMU-418889", "R-GGA-9013106", "R-DME-9013148", "R-GGA-9013409", "R-GGA-9013404", "R-RNO-177504", "R-GGA-9013406", "R-DDI-9013423", "R-RNO-9013408", "R-HSA-9013408", "R-RNO-9013404", "R-RNO-9013406", "R-DME-177504", "R-CEL-182971", "R-RNO-193648", "R-RNO-432722", "R-DDI-6798695", "R-XTR-9013409", "R-DME-9013149", "R-GGA-9013148", "R-HSA-182971", "R-MMU-5620916", "R-DME-437239", "R-RNO-432720", "R-RNO-5620916", "R-BTA-182971", "R-HSA-432720", "R-DME-8980692", "R-HSA-437239", "R-HSA-416482", "R-RNO-9013148", "R-GGA-9013423", "R-HSA-9673768", "R-XTR-9013148", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-211728", "R-XTR-9013404", "R-MMU-9013406", "R-SPO-9013424", "R-MMU-193648", "R-HSA-9013026", "R-MMU-6798695", "R-BTA-8980692", "R-DRE-8980692", "R-DME-182971", "R-HSA-9031628", "R-RNO-6794361", "R-CEL-8856825", "R-RNO-6798695", "R-DRE-9013423", "R-HSA-2132295", "R-DME-432720", "R-MMU-8856825", "R-MMU-8980692", "R-CEL-432720", "R-RNO-8980692", "R-CEL-437239", "R-MMU-432722", "R-HSA-418889", "R-MMU-9013148", "R-XTR-9013026", "R-HSA-9013106", "R-DRE-9013404", "R-BTA-9013148", "R-DDI-9013149", "R-HSA-9013423", "R-HSA-5620916", "R-DME-5620916", "R-RNO-416482", "R-MMU-2132295", "R-HSA-9013148", "R-DME-9013406", "R-XTR-9013423", "R-DRE-9013149", "R-DME-8856828", "R-RNO-8856828", "R-SPO-9013420", "R-RNO-9013106", "R-MMU-432720", "R-GGA-9013149", "R-HSA-432722", "R-BTA-6807004", "R-SPO-983168", "R-DME-9013423", "R-BTA-8856828", "R-DME-8856825", "R-HSA-193648", "R-CEL-8856828", "R-RNO-2132295", "R-MMU-437239", "R-RNO-8856825", "R-CEL-6807004", "R-RNO-437239", "R-MMU-6794361", "R-DME-432722", "R-HSA-6807004", "R-RNO-9013423", "R-HSA-177504", "R-RNO-6807004", "R-XTR-8980692", "R-DRE-9013148", "R-BTA-8856825", "R-HSA-8856825", "R-XTR-9013406", "R-GGA-8980692", "R-MMU-416482", "R-MMU-177504", "R-MMU-9013026", "R-MMU-264870", "R-DME-9013409", "R-RNO-264870", "R-MMU-6807004", "R-RNO-182971", "R-HSA-9013406", "R-MMU-9013149", "R-HSA-8875360"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-XTR-9013106:r:RHOC GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-182971:r:EGFR downregulation", "R-SPO-5689901:r:Metalloprotease DUBs", "R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-9013026:r:RHOB GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-GGA-9013106:r:RHOC GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-GGA-9013409:r:RHOJ GTPase cycle", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-CEL-182971:r:EGFR downregulation", "R-RNO-193648:r:NRAGE signals death through JNK", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-6798695:r:Neutrophil degranulation", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-437239:r:Recycling pathway of L1", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-182971:r:EGFR downregulation", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-9013424:r:RHOV GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DME-182971:r:EGFR downregulation", "R-HSA-9031628:r:NGF-stimulated transcription", "R-RNO-6794361:r:Neurexins and neuroligins", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6798695:r:Neutrophil degranulation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-CEL-437239:r:Recycling pathway of L1", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-XTR-9013026:r:RHOB GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-6807004:r:Negative regulation of MET activity", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-9013423:r:RAC3 GTPase cycle", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-193648:r:NRAGE signals death through JNK", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-6807004:r:Negative regulation of MET activity", "R-RNO-437239:r:Recycling pathway of L1", "R-MMU-6794361:r:Neurexins and neuroligins", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-6807004:r:Negative regulation of MET activity", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-RNO-6807004:r:Negative regulation of MET activity", "R-XTR-8980692:r:RHOA GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-GGA-8980692:r:RHOA GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-DME-9013409:r:RHOJ GTPase cycle", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-6807004:r:Negative regulation of MET activity", "R-RNO-182971:r:EGFR downregulation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell"], "type": "Domain"}, "IPR004149": {"description": "Zinc-finger, NAD-dependent DNA ligase C4-type", "go_ids": ["GO:0003911", "GO:0006260", "GO:0006281"], "go_terms": ["GO:0003911:DNA ligase (NAD+) activity:F", "GO:0006260:DNA replication:P", "GO:0006281:DNA repair:P"], "name": "Znf_DNAligase_C4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004150": {"description": "NAD-dependent DNA ligase, OB-fold", "go_ids": ["GO:0003911", "GO:0006260", "GO:0006281"], "go_terms": ["GO:0003911:DNA ligase (NAD+) activity:F", "GO:0006260:DNA replication:P", "GO:0006281:DNA repair:P"], "name": "NAD_DNA_ligase_OB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004151": {"description": "7TM GPCR, serpentine receptor class e (Sre)", "go_ids": ["GO:0007606", "GO:0016020"], "go_terms": ["GO:0007606:sensory perception of chemical stimulus:P", "GO:0016020:membrane:C"], "name": "7TM_GPCR_serpentine_rcpt_Sre", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004152": {"description": "GAT domain", "go_ids": ["GO:0043130", "GO:0035091"], "go_terms": ["GO:0043130:ubiquitin binding:F", "GO:0035091:phosphatidylinositol binding:F"], "name": "GAT_dom", "pathway_ids": ["R-HSA-6798695", "R-RNO-8875656", "R-SPO-5689901", "R-HSA-8854214", "R-MMU-8875656", "R-HSA-977225", "R-MMU-6798695", "R-SPO-9013420", "R-HSA-8875656", "R-GGA-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-8875656:r:MET receptor recycling", "R-SPO-5689901:r:Metalloprotease DUBs", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-8875656:r:MET receptor recycling", "R-GGA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR004153": {"description": "CXCXC repeat", "go_ids": [], "go_terms": [], "name": "CXCXC_repeat", "pathway_ids": ["R-MMU-195399", "R-HSA-114608", "R-MMU-114608", "R-HSA-194313", "R-HSA-195399", "R-RNO-195399", "R-MMU-194313", "R-RNO-114608", "R-RNO-194313"], "pathways": ["R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-194313:r:VEGF ligand-receptor interactions", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-194313:r:VEGF ligand-receptor interactions", "R-RNO-114608:r:Platelet degranulation", "R-RNO-194313:r:VEGF ligand-receptor interactions"], "type": "Repeat"}, "IPR004154": {"description": "Anticodon-binding", "go_ids": [], "go_terms": [], "name": "Anticodon-bd", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-HSA-2408522", "R-HSA-2151201", "R-HSA-6782315", "R-MMU-9913635", "R-DME-9856649", "R-DME-9913635", "R-HSA-9856649", "R-HSA-379716", "R-BTA-9913635", "R-HSA-9913635"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-BTA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR004155": {"description": "PBS lyase HEAT-like repeat", "go_ids": [], "go_terms": [], "name": "PBS_lyase_HEAT", "pathway_ids": ["R-RNO-204626", "R-MMU-204626", "R-CEL-204626", "R-HSA-204626", "R-DRE-204626", "R-DDI-204626", "R-DME-204626", "R-SCE-204626", "R-GGA-204626", "R-SPO-204626", "R-BTA-204626"], "pathways": ["R-RNO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DRE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DDI-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DME-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SCE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-GGA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-BTA-204626:r:Hypusine synthesis from eIF5A-lysine"], "type": "Repeat"}, "IPR004156": {"description": "Organic anion transporter polypeptide", "go_ids": ["GO:0016020", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "OATP", "pathway_ids": ["R-HSA-6798695", "R-HSA-5619058", "R-HSA-879518", "R-DME-6798695", "R-DME-879518", "R-RNO-879518", "R-BTA-879518", "R-MMU-9793528", "R-HSA-189483", "R-MMU-189483", "R-HSA-5619110", "R-HSA-9754706", "R-RNO-9793528", "R-MMU-879518", "R-MMU-9754706", "R-RNO-159418", "R-RNO-9754706", "R-HSA-9749641", "R-HSA-9793528", "R-MMU-6798695", "R-HSA-159418", "R-MMU-9749641", "R-RNO-9749641", "R-RNO-189483", "R-MMU-159418", "R-RNO-6798695", "R-HSA-5619095"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5619058:r:Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)", "R-HSA-879518:r:Organic anion transport by SLCO transporters", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-879518:r:Organic anion transport by SLCO transporters", "R-RNO-879518:r:Organic anion transport by SLCO transporters", "R-BTA-879518:r:Organic anion transport by SLCO transporters", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-HSA-189483:r:Heme degradation", "R-MMU-189483:r:Heme degradation", "R-HSA-5619110:r:Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "R-HSA-9754706:r:Atorvastatin ADME", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-MMU-879518:r:Organic anion transport by SLCO transporters", "R-MMU-9754706:r:Atorvastatin ADME", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-9754706:r:Atorvastatin ADME", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-159418:r:Recycling of bile acids and salts", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-9749641:r:Aspirin ADME", "R-RNO-189483:r:Heme degradation", "R-MMU-159418:r:Recycling of bile acids and salts", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5619095:r:Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)"], "type": "Family"}, "IPR004158": {"description": "Protein of unknown function DUF247, plant", "go_ids": [], "go_terms": [], "name": "DUF247_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004159": {"description": "Putative S-adenosyl-L-methionine-dependent methyltransferase", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "Put_SAM_MeTrfase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR004160": {"description": "Translation elongation factor EFTu/EF1A, C-terminal", "go_ids": [], "go_terms": [], "name": "Transl_elong_EFTu/EF1A_C", "pathway_ids": ["R-HSA-9754560", "R-HSA-5389840"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-5389840:r:Mitochondrial translation elongation"], "type": "Domain"}, "IPR004161": {"description": "Translation elongation factor EFTu-like, domain 2", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "EFTu-like_2", "pathway_ids": ["R-HSA-9833482", "R-HSA-9010553", "R-HSA-381042", "R-SPO-72731", "R-RNO-382556", "R-BTA-5358493", "R-DRE-156902", "R-HSA-72695", "R-SPO-5358493", "R-SCE-72731", "R-MMU-3371511", "R-BTA-72731", "R-HSA-5389840", "R-DME-156842", "R-SCE-72702", "R-DRE-5358493", "R-DDI-6798695", "R-RNO-156902", "R-MMU-156842", "R-HSA-2408557", "R-SCE-5358493", "R-DME-72731", "R-GGA-3371511", "R-BTA-156842", "R-MMU-72163", "R-BTA-72702", "R-RNO-3371511", "R-DDI-3371511", "R-HSA-72706", "R-DDI-72764", "R-HSA-72702", "R-DDI-8876725", "R-DME-8876725", "R-SPO-156842", "R-RNO-72649", "R-HSA-72163", "R-DDI-72731", "R-BTA-156902", "R-DME-5389840", "R-DME-72702", "R-RNO-6798695", "R-DME-5358493", "R-SCE-8876725", "R-DDI-382556", "R-RNO-5358493", "R-BTA-3371511", "R-SCE-6798695", "R-CEL-3371511", "R-RNO-9840373", "R-DME-72649", "R-HSA-156827", "R-GGA-8876725", "R-DRE-72731", "R-DRE-381042", "R-MMU-72731", "R-HSA-5336415", "R-HSA-72165", "R-SCE-72764", "R-SCE-72695", "R-RNO-5389840", "R-MMU-975956", "R-MMU-72764", "R-BTA-9840373", "R-MMU-382556", "R-SCE-156827", "R-MMU-72695", "R-CEL-5389840", "R-DME-6798695", "R-RNO-156842", "R-MMU-975957", "R-RNO-72702", "R-GGA-156842", "R-HSA-72764", "R-HSA-72649", "R-MMU-156827", "R-HSA-975957", "R-DRE-72702", "R-RNO-429958", "R-DME-9954714", "R-MMU-72165", "R-SCE-156902", "R-DDI-975957", "R-SPO-72163", "R-DDI-156827", "R-RNO-9954714", "R-MMU-9840373", "R-HSA-6798695", "R-SCE-382556", "R-CEL-156902", "R-CEL-6798695", "R-BTA-6798695", "R-DME-156902", "R-MMU-381042", "R-RNO-72695", "R-MMU-72706", "R-HSA-975956", "R-DRE-6798695", "R-BTA-72695", "R-BTA-381042", "R-HSA-429958", "R-BTA-8876725", "R-BTA-156827", "R-RNO-156827", "R-DRE-72695", "R-CEL-5358493", "R-SPO-72706", "R-MMU-9954714", "R-SCE-975956", "R-DDI-72695", "R-RNO-381042", "R-HSA-9735869", "R-GGA-6798695", "R-DME-9840373", "R-SCE-9840373", "R-HSA-9648895", "R-DDI-9840373", "R-MMU-5358493", "R-SCE-156842", "R-MMU-6798695", "R-HSA-9613829", "R-SPO-156827", "R-DDI-381042", "R-HSA-9954714", "R-BTA-72649", "R-MMU-5389840", "R-DDI-72702", "R-HSA-3371511", "R-HSA-72731", "R-DRE-382556", "R-SPO-6798695", "R-HSA-8876725", "R-SPO-72702", "R-SPO-382556", "R-DME-156827", "R-BTA-382556", "R-DDI-975956", "R-DME-382556", "R-MMU-429958", "R-DME-381042", "R-MMU-72649", "R-SPO-156902", "R-HSA-9754560", "R-SCE-975957", "R-DRE-9840373", "R-DDI-156902", "R-HSA-9918481", "R-DRE-5419276", "R-HSA-9840373", "R-DRE-156827", "R-DME-72695", "R-MMU-72702", "R-SPO-72649", "R-SPO-72695", "R-HSA-156842", "R-HSA-382556", "R-SPO-9840373", "R-HSA-156902", "R-RNO-72731", "R-CEL-8876725", "R-SPO-8876725", "R-DME-3371511", "R-DRE-5389840", "R-MMU-156902", "R-MMU-8876725", "R-DRE-72649", "R-SPO-3371511", "R-SCE-72649", "R-DRE-8876725", "R-DME-429958", "R-HSA-5358493", "R-RNO-8876725", "R-SCE-3371511", "R-DDI-5358493", "R-DDI-156842", "R-HSA-9633012"], "pathways": ["R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-381042:r:PERK regulates gene expression", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-156902:r:Peptide chain elongation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-MMU-3371511:r:HSF1 activation", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DME-156842:r:Eukaryotic Translation Elongation", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-156902:r:Peptide chain elongation", "R-MMU-156842:r:Eukaryotic Translation Elongation", "R-HSA-2408557:r:Selenocysteine synthesis", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-DME-72731:r:Recycling of eIF2:GDP", "R-GGA-3371511:r:HSF1 activation", "R-BTA-156842:r:Eukaryotic Translation Elongation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-3371511:r:HSF1 activation", "R-DDI-3371511:r:HSF1 activation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-72764:r:Eukaryotic Translation Termination", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-8876725:r:Protein methylation", "R-DME-8876725:r:Protein methylation", "R-SPO-156842:r:Eukaryotic Translation Elongation", "R-RNO-72649:r:Translation initiation complex formation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-BTA-156902:r:Peptide chain elongation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-8876725:r:Protein methylation", "R-DDI-382556:r:ABC-family proteins mediated transport", 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"R-HSA-1483166", "R-DRE-983168", "R-MMU-5689880", "R-RNO-4641257", "R-HSA-4641257", "R-HSA-3270619", "R-BTA-8948751", "R-MMU-3270619", "R-DRE-8948751", "R-HSA-9683610", "R-MMU-3134975", "R-HSA-196807", "R-MMU-201681", "R-HSA-983168", "R-RNO-5689880", "R-HSA-9694631", "R-HSA-204005", "R-MMU-1483166", "R-MMU-4641257", "R-HSA-3134975", "R-MMU-983168", "R-HSA-8948751", "R-BTA-4641257", "R-MMU-6798695", "R-RNO-983168", "R-RNO-6798695"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-XTR-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-1483166:r:Synthesis of PA", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-4641257:r:Degradation of AXIN", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-1483166:r:Synthesis of PA", "R-MMU-4641257:r:Degradation of AXIN", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR004171": {"description": "cAMP-dependent protein kinase inhibitor", "go_ids": ["GO:0004862", "GO:0006469"], "go_terms": ["GO:0004862:cAMP-dependent protein kinase inhibitor activity:F", "GO:0006469:negative regulation of protein kinase activity:P"], "name": "cAMP_dep_PKI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004172": {"description": "L27 domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "L27_dom", "pathway_ids": ["R-HSA-9013409", "R-MMU-451308", "R-HSA-420029", "R-MMU-9013408", "R-RNO-9013149", "R-CEL-438066", "R-MMU-9013404", "R-HSA-442982", "R-DRE-9013406", "R-RNO-212676", "R-CFA-451308", "R-CFA-8849932", "R-CEL-451308", "R-HSA-9662360", "R-CFA-5673001", "R-RNO-9013404", "R-RNO-9013406", "R-HSA-9013408", "R-RNO-9013408", "R-HSA-9705677", "R-HSA-447038", "R-RNO-5673001", "R-DME-438066", "R-MMU-5673001", "R-HSA-373753", "R-HSA-451308", "R-MMU-8849932", "R-MMU-438066", "R-XTR-9013408", "R-CEL-212676", "R-RNO-438066", "R-HSA-5673001", "R-HSA-9013404", "R-DRE-8849932", "R-MMU-9013423", "R-HSA-9013149", "R-XTR-9013404", "R-HSA-9620244", "R-MMU-9013406", "R-CFA-399719", "R-RNO-6794361", "R-RNO-8849932", "R-HSA-9609736", "R-HSA-212676", "R-DME-5625900", "R-DRE-9013423", "R-CEL-8849932", "R-DME-983168", "R-DRE-438066", "R-BTA-9013406", "R-DRE-9013404", "R-HSA-8849932", "R-HSA-6794361", "R-BTA-9013423", "R-HSA-9013423", "R-CEL-5625900", "R-RNO-5666185", "R-BTA-212676", "R-XTR-9013423", "R-DRE-9013149", "R-HSA-9692912", "R-RNO-451308", "R-HSA-9617324", "R-MMU-5666185", "R-BTA-5666185", "R-DRE-9013408", "R-HSA-399719", "R-XTR-8849932", "R-MMU-212676", "R-CEL-6794361", "R-HSA-3000170", "R-HSA-5666185", "R-HSA-9662361", "R-MMU-6794361", "R-RNO-399719", "R-DME-212676", "R-DME-451308", "R-RNO-9013423", "R-BTA-9013408", "R-DME-8849932", "R-HSA-438066", "R-XTR-9013406", "R-BTA-9013404", "R-XTR-438066", "R-DME-6794361", "R-CFA-438066", "R-HSA-9013406", "R-MMU-9013149", "R-MMU-399719"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-420029:r:Tight junction interactions", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-HSA-447038:r:NrCAM interactions", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-XTR-9013408:r:RHOG GTPase cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-HSA-9620244:r:Long-term potentiation", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-5625900:r:RHO GTPases activate CIT", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-6794361:r:Neurexins and neuroligins", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-6794361:r:Neurexins and neuroligins", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-6794361:r:Neurexins and neuroligins", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors"], "type": "Domain"}, "IPR004173": {"description": "3H domain", "go_ids": ["GO:0036094"], "go_terms": ["GO:0036094:small molecule binding:F"], "name": "3H_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004174": {"description": "Head-to-tail joining protein W", "go_ids": ["GO:0019058"], "go_terms": ["GO:0019058:viral life cycle:P"], "name": "GpW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004175": {"description": "RNA 2',3'-cyclic phosphodiesterase", "go_ids": ["GO:0008664", "GO:0004113"], "go_terms": ["GO:0008664:RNA 2',3'-cyclic 3'-phosphodiesterase activity:F", "GO:0004113:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity:F"], "name": "RNA_CPDase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004176": {"description": "Clp, repeat (R) N-terminal domain", "go_ids": [], "go_terms": [], "name": "Clp_R_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004177": {"description": "DDHD domain", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "DDHD_dom", "pathway_ids": ["R-HSA-204005", "R-MMU-1483166", "R-HSA-1483226", "R-MMU-204005", "R-SPO-1483166", "R-SCE-1483226", "R-CEL-1483226", "R-MMU-1483226", "R-SCE-204005", "R-SPO-204005", "R-RNO-1483226", "R-HSA-1483166", "R-SCE-1483166", "R-DME-1483226", "R-SPO-1483226"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-1483226:r:Synthesis of PI", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-SPO-1483166:r:Synthesis of PA", "R-SCE-1483226:r:Synthesis of PI", "R-CEL-1483226:r:Synthesis of PI", "R-MMU-1483226:r:Synthesis of PI", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-RNO-1483226:r:Synthesis of PI", "R-HSA-1483166:r:Synthesis of PA", "R-SCE-1483166:r:Synthesis of PA", "R-DME-1483226:r:Synthesis of PI", "R-SPO-1483226:r:Synthesis of PI"], "type": "Domain"}, "IPR004178": {"description": "Calmodulin-binding domain", "go_ids": ["GO:0005516", "GO:0006813", "GO:0015269", "GO:0016020"], "go_terms": ["GO:0005516:calmodulin binding:F", "GO:0006813:potassium ion transport:P", "GO:0015269:calcium-activated potassium channel activity:F", "GO:0016020:membrane:C"], "name": "CaM-bd_dom", "pathway_ids": ["R-DME-1296052", "R-RNO-1296052", "R-HSA-9667769", "R-HSA-1296052", "R-CEL-1296052", "R-MMU-1296052", "R-SSC-1296052"], "pathways": ["R-DME-1296052:r:Ca2+ activated K+ channels", "R-RNO-1296052:r:Ca2+ activated K+ channels", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-HSA-1296052:r:Ca2+ activated K+ channels", "R-CEL-1296052:r:Ca2+ activated K+ channels", "R-MMU-1296052:r:Ca2+ activated K+ channels", "R-SSC-1296052:r:Ca2+ activated K+ channels"], "type": "Domain"}, "IPR004179": {"description": "Sec63 domain", "go_ids": [], "go_terms": [], "name": "Sec63-dom", "pathway_ids": ["R-HSA-9954716", "R-BTA-9954716", "R-CEL-72165", "R-MMU-72163", "R-DME-72163", "R-RNO-72163", "R-DDI-72163", "R-GGA-9954716", "R-HSA-72163", "R-MMU-9954716", "R-HSA-112126", "R-RNO-9954716", "R-DME-72165", "R-MMU-72165", "R-RNO-72165", "R-HSA-72165", "R-CEL-72163", "R-SPO-72163", "R-HSA-9918481", "R-DDI-9954716"], "pathways": ["R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "type": "Domain"}, "IPR004180": {"description": "Protein of unknown function DUF226, Borrelia species", "go_ids": [], "go_terms": [], "name": "DUF226_BOR_spp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004181": {"description": "Zinc finger, MIZ-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_MIZ", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-HSA-4755510", "R-DRE-4085377", "R-DRE-3232142", "R-HSA-5693565", "R-RNO-3108214", "R-SCE-4085377", "R-MMU-69473", "R-MMU-5696395", "R-DRE-5693571", "R-MMU-4551638", "R-SPO-5696395", "R-HSA-5693607", "R-RNO-3232118", "R-MMU-3232118", "R-CEL-4551638", "R-HSA-4090294", "R-SPO-4085377", "R-SPO-3899300", "R-HSA-4551638", "R-RNO-4090294", "R-RNO-3899300", "R-CEL-4085377", "R-HSA-69473", "R-RNO-5696395", "R-CEL-3232118", "R-HSA-3232142", "R-CEL-4090294", "R-DRE-196791", "R-DRE-3232118", "R-CEL-5696395", "R-HSA-5696395", "R-MMU-196791", "R-HSA-3232118", "R-RNO-3232142", "R-DRE-5693565", "R-MMU-3108214", "R-MMU-5693571", "R-HSA-5617472", "R-SPO-3232118", "R-SCE-3108214", "R-RNO-4615885", "R-DRE-5693607", "R-MMU-3232142", "R-HSA-3108214", "R-DRE-4615885", "R-CEL-3899300", "R-MMU-4615885", "R-MMU-5693565", "R-DRE-3108214", "R-MMU-4085377", "R-HSA-196791", "R-HSA-877312", "R-CEL-3232142", "R-CEL-3108214", "R-MMU-4090294", "R-HSA-4615885", "R-SCE-3232118", "R-MMU-877312", "R-MMU-5693607", "R-SPO-3108214", "R-MMU-3899300", "R-DRE-4755510", "R-SPO-4551638", "R-HSA-4085377", "R-RNO-4755510", "R-DRE-3899300", "R-RNO-4551638", "R-HSA-5693571", "R-SCE-4551638", "R-DRE-4090294", "R-CEL-877312", "R-HSA-3899300", "R-MMU-4755510"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-DRE-4085377:r:SUMOylation of SUMOylation proteins", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-CEL-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CEL-4090294:r:SUMOylation of intracellular receptors", "R-DRE-196791:r:Vitamin D (calciferol) metabolism", "R-DRE-3232118:r:SUMOylation of transcription factors", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SPO-3232118:r:SUMOylation of transcription factors", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-877312:r:Regulation of IFNG signaling", "R-CEL-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-DRE-4755510:r:SUMOylation of immune response proteins", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-4755510:r:SUMOylation of immune response proteins", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SCE-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-4090294:r:SUMOylation of intracellular receptors", "R-CEL-877312:r:Regulation of IFNG signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-4755510:r:SUMOylation of immune response proteins"], "type": "Domain"}, "IPR004182": {"description": "GRAM domain", "go_ids": [], "go_terms": [], "name": "GRAM", "pathway_ids": ["R-CEL-1660516", "R-BTA-1660499", "R-BTA-1660516", "R-HSA-1660517", "R-HSA-5626978", "R-MMU-1660516", "R-MMU-432722", "R-DDI-5674499", "R-DRE-1660517", "R-HSA-1660499", "R-MMU-1483248", "R-CEL-9035034", "R-DDI-5675482", "R-DDI-170968", "R-DDI-5213460", "R-CEL-8876198", "R-RNO-1660516", "R-HSA-9035034", "R-DRE-1483248", "R-DDI-5673000", "R-BTA-1660517", "R-MMU-5626978", "R-HSA-432722", "R-DDI-5689880", "R-BTA-1483248", "R-MMU-9035034", "R-HSA-1483248", "R-DDI-3295583", "R-DDI-392517", "R-HSA-8876198", "R-DDI-5675221", "R-HSA-1660516", "R-CEL-1483248", "R-MMU-1660499", "R-DDI-5621575", "R-RNO-1660517", "R-DDI-5674135", "R-MMU-8876198", "R-RNO-1660499", "R-DDI-168638", "R-CEL-1660499", "R-CEL-1660517", "R-MMU-1660517", "R-DRE-1660516"], "pathways": ["R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-DRE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-9035034:r:RHOF GTPase cycle", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DDI-170968:r:Frs2-mediated activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DRE-1483248:r:Synthesis of PIPs at the ER membrane", "R-DDI-5673000:r:RAF activation", "R-BTA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-5689880:r:Ub-specific processing proteases", "R-BTA-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-DDI-3295583:r:TRP channels", "R-DDI-392517:r:Rap1 signalling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DRE-1660516:r:Synthesis of PIPs at the early endosome membrane"], "type": "Domain"}, "IPR004183": {"description": "Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B", "go_ids": ["GO:0008198", "GO:0016491"], "go_terms": ["GO:0008198:ferrous iron binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "Xdiol_dOase_suB", "pathway_ids": ["PWY-6690"], "pathways": ["PWY-6690:t:cinnamate and 3-hydroxycinnamate degradation to 2-hydroxypentadienoate"], "type": "Domain"}, "IPR004184": {"description": "Pyruvate formate lyase domain", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "PFL_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004185": {"description": "Glycoside hydrolase, family 13, N-terminal Ig-like domain", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_13_lg-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004186": {"description": "Epstein Barr virus nuclear antigen-1, DNA-binding", "go_ids": ["GO:0042025", "GO:0045893", "GO:0006275", "GO:0003677"], "go_terms": ["GO:0042025:host cell nucleus:C", "GO:0045893:positive regulation of DNA-templated transcription:P", "GO:0006275:regulation of DNA replication:P", "GO:0003677:DNA binding:F"], "name": "EBNA1_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004188": {"description": "Phenylalanine-tRNA ligase, class II, N-terminal", "go_ids": ["GO:0000166", "GO:0004826", "GO:0005524", "GO:0005737", "GO:0006432"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004826:phenylalanine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006432:phenylalanyl-tRNA aminoacylation:P"], "name": "Phe-tRNA_ligase_II_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004189": {"description": "Bacteriophage Mu, transposase", "go_ids": ["GO:0003677", "GO:0004803", "GO:0006313", "GO:0015074"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004803:transposase activity:F", "GO:0006313:DNA transposition:P", "GO:0015074:DNA integration:P"], "name": "Phage_Mu_transposase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004190": {"description": "DNA polymerase processivity factor", "go_ids": ["GO:0006260"], "go_terms": ["GO:0006260:DNA replication:P"], "name": "DNA_pol_proc_fac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004191": {"description": "Transposase from transposon Tn916/Tn1545-like, N-terminal DNA binding", "go_ids": ["GO:0003677", "GO:0008907", "GO:0015074"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008907:integrase activity:F", "GO:0015074:DNA integration:P"], "name": "Tn916-type_DNA-bd_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004192": {"description": "Cytochrome b-c1 complex subunit Rieske, transmembrane domain", "go_ids": ["GO:0008121"], "go_terms": ["GO:0008121:quinol-cytochrome-c reductase activity:F"], "name": "Rieske_TM", "pathway_ids": ["PWY-7279", "PWY-6692", "PWY-3781", "R-HSA-9865881", "R-DRE-9865881", "R-GGA-9865881", "R-SCE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SPO-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-MMU-611105", "R-RNO-9865881", "R-BTA-9865881", "R-SPO-611105", "R-SCE-611105", "R-SSC-9865881", "R-BTA-611105", "R-DME-9865881"], "pathways": ["PWY-7279:t:aerobic respiration II 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family 13, N-terminal", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_13_N", "pathway_ids": ["PWY-622", "PWY-7900", "PWY-5067", "R-HSA-3322077", "R-SCE-3322077", "R-HSA-3878781", "R-MMU-3322077"], "pathways": ["PWY-622:t:starch biosynthesis", "PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)", "PWY-5067:t:glycogen biosynthesis II (from UDP-D-Glucose)", "R-HSA-3322077:r:Glycogen synthesis", "R-SCE-3322077:r:Glycogen synthesis", "R-HSA-3878781:r:Glycogen storage disease type IV (GBE1)", "R-MMU-3322077:r:Glycogen synthesis"], "type": "Domain"}, "IPR004194": {"description": "Restriction endonuclease, type II, BamHI", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_BamHI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004195": {"description": "Head decoration protein D", "go_ids": [], "go_terms": [], "name": "Head_decoration_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004196": {"description": "Scaffold protein D", "go_ids": ["GO:0046797"], "go_terms": ["GO:0046797:viral procapsid maturation:P"], "name": "Scaffold_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004197": {"description": "Cellulase, Ig-like domain", "go_ids": ["GO:0005975", "GO:0008810"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0008810:cellulase activity:F"], "name": "Cellulase_Ig-like", "pathway_ids": ["PWY-6788"], "pathways": ["PWY-6788:t:cellulose degradation II (fungi)"], "type": "Domain"}, "IPR004198": {"description": "Zinc finger, C5HC2-type", "go_ids": [], "go_terms": [], "name": "Znf_C5HC2", "pathway_ids": ["R-HSA-8866911", "R-HSA-212300", "R-DRE-3214842", "R-MMU-8866911", "R-DRE-212300", "R-MMU-3214842", "R-HSA-9821002", "R-DME-8866911", "R-DME-212300", "R-HSA-3214842", "R-CEL-3214842", "R-MMU-212300", "R-DRE-8866911"], "pathways": 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{"description": "Influenza non-structural protein (NS1)", "go_ids": [], "go_terms": [], "name": "NS1", "pathway_ids": ["R-HSA-5213460", "R-HSA-168888", "R-HSA-168276", "R-HSA-9833482", "R-HSA-168315", "R-HSA-1169408", "R-HSA-9686347", "R-HSA-169131", "R-HSA-9953170", "R-HSA-192823"], "pathways": ["R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-168888:r:Inhibition of IFN-beta", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-168315:r:Inhibition of Host mRNA Processing and RNA Silencing", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-169131:r:Inhibition of PKR", "R-HSA-9953170:r:GBP-mediated host defense", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Family"}, "IPR004209": {"description": "Ferredoxin thioredoxin reductase catalytic beta subunit", "go_ids": ["GO:0016730"], "go_terms": ["GO:0016730:oxidoreductase activity, acting on 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"R-DME-1268020", "R-SPO-1268020"], "pathways": ["R-DDI-1268020:r:Mitochondrial protein import", "R-DRE-1268020:r:Mitochondrial protein import", "R-HSA-1268020:r:Mitochondrial protein import", "R-GGA-1268020:r:Mitochondrial protein import", "R-BTA-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SCE-1268020:r:Mitochondrial protein import", "R-DME-1268020:r:Mitochondrial protein import", "R-SPO-1268020:r:Mitochondrial protein import"], "type": "Domain"}, "IPR004218": {"description": "Prokaryotic glutathione synthetase, ATP-binding", "go_ids": ["GO:0004363", "GO:0005524", "GO:0006750"], "go_terms": ["GO:0004363:glutathione synthase activity:F", "GO:0005524:ATP binding:F", "GO:0006750:glutathione biosynthetic process:P"], "name": "GSHS_ATP-bd", "pathway_ids": ["PWY-8043"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis"], "type": "Domain"}, "IPR004219": {"description": "Capsid protein ORF1, Anelloviridae", "go_ids": [], "go_terms": [], "name": "ORF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004220": {"description": "5-carboxymethyl-2-hydroxymuconate isomerase", "go_ids": ["GO:0009056", "GO:0008704"], "go_terms": ["GO:0009056:catabolic process:P", "GO:0008704:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity:F"], "name": "5-COMe_2-OHmuconate_Isoase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004221": {"description": "Restriction endonuclease, type II, EcoRI", "go_ids": ["GO:0000287", "GO:0003677", "GO:0009036", "GO:0009307"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0003677:DNA binding:F", "GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_II_EcoRI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004222": {"description": "Methane monooxygenase, gamma chain", "go_ids": ["GO:0015049", "GO:0015947"], "go_terms": ["GO:0015049:methane monooxygenase [NAD(P)H] activity:F", "GO:0015947:methane metabolic process:P"], "name": "Me_mOase_g", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004223": {"description": "Vitamin B12-dependent methionine synthase, activation domain", "go_ids": ["GO:0008705"], "go_terms": ["GO:0008705:methionine synthase activity:F"], "name": "VitB12-dep_Met_synth_activ_dom", "pathway_ids": ["PWY-3841", "PWY-2201", "R-CEL-156581", "R-RNO-1614635", "R-MMU-9013407", "R-CEL-9759218", "R-RNO-9759218", "R-RNO-9013407", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-DDI-1614635", "R-MMU-9759218", "R-MMU-1614635", "R-HSA-156581", "R-HSA-9759218", "R-RNO-156581", "R-HSA-3359467", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["PWY-3841:t:folate transformations II (plants)", "PWY-2201:t:folate transformations I", "R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-156581:r:Methylation", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Domain"}, "IPR004224": {"description": "Fumarate reductase type B, transmembrane subunit", "go_ids": ["GO:0006099"], "go_terms": ["GO:0006099:tricarboxylic acid cycle:P"], "name": "Fum_red_B_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004226": {"description": "Tubulin binding cofactor A", "go_ids": ["GO:0007021", "GO:0007023", "GO:0048487"], "go_terms": ["GO:0007021:tubulin complex assembly:P", "GO:0007023:post-chaperonin tubulin folding pathway:P", "GO:0048487:beta-tubulin binding:F"], "name": "TBCA", "pathway_ids": ["R-HSA-389977"], "pathways": ["R-HSA-389977:r:Post-chaperonin tubulin folding pathway"], "type": "Family"}, "IPR004227": {"description": "Formiminotransferase catalytic domain", "go_ids": ["GO:0005542", "GO:0016740"], "go_terms": ["GO:0005542:folic acid binding:F", "GO:0016740:transferase activity:F"], "name": "Formiminotransferase_cat", "pathway_ids": ["PWY-5030", "PWY-5497", "R-MMU-70921", "R-RNO-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Domain"}, "IPR004228": {"description": "Phycoerythrin alpha chain", "go_ids": ["GO:0030089"], "go_terms": ["GO:0030089:phycobilisome:C"], "name": "Phycoerythr_a", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004229": {"description": "Methylamine dehydrogenase light chain", "go_ids": ["GO:0030288", "GO:0052876"], "go_terms": ["GO:0030288:outer membrane-bounded periplasmic space:C", "GO:0052876:methylamine dehydrogenase (amicyanin) activity:F"], "name": "MeN_DH_Ltc", "pathway_ids": ["PWY-6967"], "pathways": ["PWY-6967:t:methylamine degradation I"], "type": "Family"}, "IPR004230": {"description": "DNA mismatch repair protein MutH", "go_ids": ["GO:0003677", "GO:0004519", "GO:0006304"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004519:endonuclease activity:F", "GO:0006304:DNA modification:P"], "name": "DNA_mismatch_repair_MutH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004231": {"description": "Carboxypeptidase A inhibitor-like", "go_ids": [], "go_terms": [], "name": "COpept_A_inh-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004232": {"description": "Nitrile hydratase alpha/Thiocyanate hydrolase gamma", "go_ids": ["GO:0003824", "GO:0046914"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0046914:transition metal ion binding:F"], "name": "CN_Hdrtase_a/SCN_Hdrlase_g", "pathway_ids": ["PWY-5025", "PWY-581", "PWY-7308"], "pathways": ["PWY-5025:t:indole-3-acetate biosynthesis IV (bacteria)", "PWY-581:t:indole-3-acetate biosynthesis II", "PWY-7308:t:acrylonitrile degradation I"], "type": "Domain"}, "IPR004233": {"description": "FokI, recognition domain, subdomain 2", "go_ids": ["GO:0003677", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0009307:DNA restriction-modification system:P"], "name": "FokI_D2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004234": {"description": "FokI, recognition domain, subdomain 1", "go_ids": ["GO:0003677", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0009307:DNA restriction-modification system:P"], "name": "FokI_D1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004235": {"description": "Scytalone dehydratase", "go_ids": ["GO:0006582", "GO:0030411"], "go_terms": ["GO:0006582:melanin metabolic process:P", "GO:0030411:scytalone dehydratase activity:F"], "name": "Scytalone_dehydratase", "pathway_ids": ["PWY-7045", "PWY-8319", "PWY-7811", "PWY-6322", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7814", "PWY-6627", "PWY-6946", "PWY-6945", "PWY-7188", "PWY-5780", "PWY-7897", "PWY-7275", "PWY-5367", "PWY-8152", "PWY-8029", "PWY-6948", "PWY-8134", "PWY-7610", "PWY-7695", "PWY-7354", "PWY-8335", "PWY-6944", "PWY-7547", "PWY-8012", "PWY-2229", "PWY-5793", "PWY-7352", "PWY-2467", "PWY-8044", "PWY-6602", "PWY-6679", "PWY-7757", "PWY-7510", "PWY-5979", "PWY-721", "PWY-5644", "PWY-5408", "PWY-7821", "PWY-7189", "PWY-5410", "PWY-7613", "PWYG-321", "PWY-5061", "PWY-6721", "PWY-6672", "PWY-5409", "PWY-6749", "PWY-7428", "PWY-8151"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-8319:t:NiFe(CO)(CN)2 cofactor biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7188:t:orientin and isoorientin biosynthesis I", "PWY-5780:t:hypericin biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-7275:t:L-homophenylalanine biosynthesis", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-8134:t:bile acid 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"PWY-7189:t:pinocembrin C-glucosylation", "PWY-5410:t:traumatin and (Z)-3-hexen-1-yl acetate biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5061:t:6,7,4'-trihydroxyisoflavone biosynthesis", "PWY-6721:t:sangivamycin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-5409:t:divinyl ether biosynthesis II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7428:t:2-chloroacrylate degradation II", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)"], "type": "Family"}, "IPR004236": {"description": "Peptidase S1A, alpha-lytic prodomain", "go_ids": ["GO:0005576", "GO:0006508", "GO:0008236"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006508:proteolysis:P", "GO:0008236:serine-type peptidase activity:F"], "name": "Pept_S1_alpha_lytic", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004237": {"description": "Fibronectin binding repeat", "go_ids": [], "go_terms": [], "name": 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"R-MMU-5205685", "R-MMU-8854214", "R-MMU-9664873", "R-HSA-9754560", "R-SPO-8934903", "R-RNO-1632852", "R-XTR-1632852", "R-SCE-8934903", "R-PFA-1632852", "R-HSA-5205685", "R-HSA-8934903", "R-HSA-9694676", "R-DDI-1632852", "R-RNO-5205685", "R-RNO-9664873", "R-BTA-9664873", "R-CEL-9755511", "R-BTA-5205685", "R-SPO-8854214", "R-CEL-8934903", "R-RNO-9755511", "R-HSA-9755511", "R-SCE-8854214", "R-BTA-1632852", "R-SCE-1632852", "R-BTA-8934903", "R-DDI-9664873", "R-HSA-1632852", "R-BTA-8854214", "R-SPO-1632852", "R-HSA-9664873"], "pathways": ["R-RNO-8854214:r:TBC/RABGAPs", "R-DDI-8854214:r:TBC/RABGAPs", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8854214:r:TBC/RABGAPs", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-9664873:r:Pexophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-8854214:r:TBC/RABGAPs", "R-MMU-9664873:r:Pexophagy", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-PFA-1632852:r:Macroautophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DDI-1632852:r:Macroautophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-9664873:r:Pexophagy", "R-BTA-9664873:r:Pexophagy", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-8854214:r:TBC/RABGAPs", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-8854214:r:TBC/RABGAPs", "R-BTA-1632852:r:Macroautophagy", "R-SCE-1632852:r:Macroautophagy", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-DDI-9664873:r:Pexophagy", "R-HSA-1632852:r:Macroautophagy", "R-BTA-8854214:r:TBC/RABGAPs", "R-SPO-1632852:r:Macroautophagy", "R-HSA-9664873:r:Pexophagy"], "type": "Family"}, "IPR004242": {"description": "Transposon, En/Spm-like", "go_ids": [], "go_terms": [], "name": "Transposase_21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004243": {"description": "Minor capsid protein VI", "go_ids": ["GO:0019028", "GO:0039664"], "go_terms": ["GO:0019028:viral capsid:C", "GO:0039664:lysis of host organelle involved in viral entry into host cell:P"], "name": "McpVI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004244": {"description": "Transposase, L1", "go_ids": [], "go_terms": [], "name": "Transposase_22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004245": {"description": "Protein of unknown function DUF229", "go_ids": [], "go_terms": [], "name": "DUF229", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004247": {"description": "Lentiviral Vpr-like protein", "go_ids": [], "go_terms": [], "name": "Lentiviral_Vpr-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004248": {"description": "Borrelia plasmid, OrfD", "go_ids": [], "go_terms": [], "name": "Borrelia_plasmid_OrfD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004250": {"description": "Somatostatin", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Somatostatin", "pathway_ids": ["R-HSA-9022702", "R-CFA-375276", "R-SSC-375276", "R-HSA-418594", "R-CFA-418594", "R-RNO-375276", "R-HSA-375276", "R-SSC-418594", "R-MMU-375276", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-CFA-375276:r:Peptide ligand-binding receptors", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-HSA-418594:r:G alpha (i) signalling events", "R-CFA-418594:r:G alpha (i) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-SSC-418594:r:G alpha (i) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR004251": {"description": "Pox virus entry-fusion-complex G9/A16", "go_ids": [], "go_terms": [], "name": "Pox_virus_G9/A16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004252": {"description": "Probable transposase, Ptta/En/Spm, plant", "go_ids": [], "go_terms": [], "name": "Probable_transposase_24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004254": {"description": "AdipoR/Haemolysin-III-related", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "AdipoR/HlyIII-related", "pathway_ids": ["R-MMU-5675221", "R-MMU-163680", "R-HSA-163680", "R-HSA-5675221"], "pathways": ["R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR004255": {"description": "O-acyltransferase, WSD1-like, N-terminal", "go_ids": ["GO:0004144", "GO:0045017"], "go_terms": ["GO:0004144:diacylglycerol O-acyltransferase activity:F", "GO:0045017:glycerolipid biosynthetic process:P"], "name": "O-acyltransferase_WSD1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004256": {"description": "Domain of unknown function DUF234", "go_ids": [], "go_terms": [], "name": "DUF234", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004257": {"description": "Glycoprotein 4, Equine arteritis virus", "go_ids": [], "go_terms": [], "name": "Gp4_EAV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004258": {"description": "Duffy-binding-like domain", "go_ids": [], "go_terms": [], "name": "DBL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004259": {"description": "Phosphoprotein M1-like", "go_ids": ["GO:0003968", "GO:0019083"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0019083:viral transcription:P"], "name": "PP_M1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004260": {"description": "Pyrimidine dimer DNA glycosylase", "go_ids": [], "go_terms": [], "name": "Pyr-dimer_DNA_glycosylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004261": {"description": "Hepatitis E virus structural protein 2, N-terminal domain", "go_ids": ["GO:0005198", "GO:0003723"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0003723:RNA binding:F"], "name": "SP2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004263": {"description": "Exostosin-like", "go_ids": ["GO:0009101", "GO:0016757"], "go_terms": ["GO:0009101:glycoprotein biosynthetic process:P", "GO:0016757:glycosyltransferase activity:F"], "name": "Exostosin", "pathway_ids": ["R-BTA-2022928", "R-HSA-381038", "R-CEL-2022928", "R-HSA-3656253", "R-DME-2022928", "R-DRE-2022928", "R-MMU-2022928", "R-HSA-2022928", "R-HSA-3656237"], "pathways": ["R-BTA-2022928:r:HS-GAG biosynthesis", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-DME-2022928:r:HS-GAG biosynthesis", "R-DRE-2022928:r:HS-GAG biosynthesis", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2"], "type": "Family"}, "IPR004264": {"description": "Transposase, Tnp1/En/Spm-like", "go_ids": [], "go_terms": [], "name": "Transposase_23", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004265": {"description": "Dirigent protein", "go_ids": [], "go_terms": [], "name": "Dirigent", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004267": {"description": "Influenza C virus M2 protein", "go_ids": [], "go_terms": [], "name": "CM2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004268": {"description": "Peptidoglycan biosynthesis protein MurJ", "go_ids": [], "go_terms": [], "name": "MurJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004269": {"description": "Folate receptor", "go_ids": [], "go_terms": [], "name": "Folate_rcpt", "pathway_ids": ["R-HSA-204005", "R-HSA-6798695", "R-MMU-204005", "R-MMU-163125", "R-MMU-196757", "R-MMU-5694530", "R-HSA-6807878", "R-MMU-6798695", "R-MMU-6807878", "R-HSA-196757", "R-HSA-5694530", "R-RNO-163125", "R-HSA-163125"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-196757:r:Metabolism of folate and pterines", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-196757:r:Metabolism of folate and pterines", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR004270": {"description": "Probable protein E5, alphapapillomavirus", "go_ids": [], "go_terms": [], "name": "E5_alpha", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004271": {"description": "Influenza C virus M1 protein", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "CM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004273": {"description": "Dynein heavy chain, D6 P-loop domain", "go_ids": ["GO:0007018", "GO:0030286", "GO:0008569"], "go_terms": ["GO:0007018:microtubule-based movement:P", "GO:0030286:dynein complex:C", "GO:0008569:minus-end-directed microtubule motor activity:F"], "name": "Dhc_D6_P-loop", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory 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"R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M 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"R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR004274": {"description": "FCP1 homology domain", "go_ids": [], "go_terms": [], "name": "FCP1_dom", "pathway_ids": ["R-SPO-674695", "R-HSA-167238", "R-MMU-113418", "R-CEL-4419969", "R-XTR-4419969", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-HSA-1268020", "R-HSA-167152", "R-HSA-113418", "R-SPO-6796648", "R-DME-4419969", "R-SCE-6796648", "R-SPO-113418", "R-HSA-381038", "R-CEL-75955", "R-MMU-6796648", "R-HSA-167243", "R-SCE-113418", "R-DRE-4419969", "R-SPO-4419969", "R-HSA-167242", "R-CEL-113418", "R-MMU-674695", "R-CEL-674695", "R-HSA-167290", "R-HSA-4419969", "R-HSA-167200", "R-HSA-75955", "R-CEL-112382", "R-SCE-674695", "R-BTA-4419969", "R-MMU-4419969", "R-HSA-674695", "R-RNO-4419969", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-DRE-4419969:r:Depolymerization of the Nuclear Lamina", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR004275": {"description": "Frog antimicrobial peptide, propeptide", "go_ids": [], "go_terms": [], "name": "Frog_antimicrobial_propeptide", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004276": {"description": "Glycosyltransferase family 28, N-terminal domain", "go_ids": ["GO:0005975", "GO:0016758"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016758:hexosyltransferase activity:F"], "name": "GlycoTrans_28_N", "pathway_ids": ["PWY-6470", "PWY-6471", "PWY-5265", "PWY-6385"], "pathways": ["PWY-6470:t:peptidoglycan biosynthesis V (beta-lactam resistance)", "PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)"], "type": "Domain"}, "IPR004277": {"description": "Phosphatidyl serine synthase", "go_ids": ["GO:0006659", "GO:0106245"], "go_terms": ["GO:0006659:phosphatidylserine biosynthetic process:P", "GO:0106245:L-serine-phosphatidylethanolamine phosphatidyltransferase activity:F"], "name": "PSS", "pathway_ids": ["PWY-7506", "PWY-7501", "PWY-6273", "R-MMU-1483101", "R-BTA-1483101", "R-XTR-1483101", "R-HSA-1483101", "R-GGA-1483101", "R-DME-1483101", "R-DRE-1483101", "R-RNO-1483101"], "pathways": ["PWY-7506:t:phosphatidylserine biosynthesis II", "PWY-7501:t:phosphatidylserine biosynthesis I", "PWY-6273:t:phosphatidylethanolamine biosynthesis III", "R-MMU-1483101:r:Synthesis of PS", "R-BTA-1483101:r:Synthesis of PS", "R-XTR-1483101:r:Synthesis of PS", "R-HSA-1483101:r:Synthesis of PS", "R-GGA-1483101:r:Synthesis of PS", "R-DME-1483101:r:Synthesis of PS", "R-DRE-1483101:r:Synthesis of PS", "R-RNO-1483101:r:Synthesis of PS"], "type": "Family"}, "IPR004278": {"description": "Minor capsid protein VP2", "go_ids": [], "go_terms": [], "name": "VP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004279": {"description": "Perilipin", "go_ids": [], "go_terms": [], "name": "Perilipin", "pathway_ids": ["R-HSA-1989781", "R-HSA-9706019", "R-HSA-381340", "R-HSA-9613829", "R-HSA-9613354", "R-HSA-9615710", "R-MMU-9706019", "R-HSA-9031528", "R-HSA-6811440", "R-HSA-163560", "R-HSA-9841922", "R-MMU-6811440"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-HSA-9613354:r:Lipophagy", "R-HSA-9615710:r:Late endosomal microautophagy", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-9031528:r:NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-163560:r:Triglyceride catabolism", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR004280": {"description": "Herpesvirus UL95", "go_ids": [], "go_terms": [], "name": "Herpes_UL95", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR004281": {"description": "Interleukin-12 alpha", "go_ids": ["GO:0005143", "GO:0005576", "GO:0006955", "GO:0008083"], "go_terms": ["GO:0005143:interleukin-12 receptor binding:F", "GO:0005576:extracellular region:C", "GO:0006955:immune response:P", "GO:0008083:growth factor activity:F"], "name": "IL-12_alpha", "pathway_ids": ["R-MMU-9020591", "R-HSA-9020591", "R-MMU-8984722", "R-RNO-9020591", "R-RNO-8984722", "R-BTA-8984722", "R-HSA-6785807", "R-HSA-6783783", "R-BTA-9020591", "R-HSA-8984722"], "pathways": ["R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-RNO-9020591:r:Interleukin-12 signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-BTA-8984722:r:Interleukin-35 Signalling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-BTA-9020591:r:Interleukin-12 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling"], "type": "Family"}, "IPR004282": {"description": "Chloroplast envelope membrane protein, CemA", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "CemA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004283": {"description": "Late expression factor 2", "go_ids": ["GO:0019083"], "go_terms": ["GO:0019083:viral transcription:P"], "name": "Lef-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004284": {"description": "Birnavirus VP5 protein", "go_ids": [], "go_terms": [], "name": "Birna_VP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004285": {"description": "Herpesvirus UL87, C-terminal", "go_ids": [], "go_terms": [], "name": "Herpes_UL87_C", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Domain"}, "IPR004286": {"description": "Herpesvirus UL16/UL94", "go_ids": [], "go_terms": [], "name": "Herpes_UL16/UL94", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR004288": {"description": "Competence protein, ComC", "go_ids": ["GO:0005186"], "go_terms": ["GO:0005186:pheromone activity:F"], "name": "Competence_ComC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004289": {"description": "Herpesvirus UL92", "go_ids": [], "go_terms": [], "name": "Herpes_UL92", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR004290": {"description": "Herpesvirus UL79", "go_ids": [], "go_terms": [], "name": "Herpes_UL79", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR004291": {"description": "Transposase IS66, central domain", "go_ids": [], "go_terms": [], "name": "Transposase_IS66_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004292": {"description": "Adenoviral packaging protein 3-like", "go_ids": [], "go_terms": [], "name": "L1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004293": {"description": "Coronavirus Orf3a/b", "go_ids": [], "go_terms": [], "name": "Coronavirus_Orf3a/b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004294": {"description": "Carotenoid oxygenase", "go_ids": ["GO:0016702"], "go_terms": ["GO:0016702:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen:F"], "name": "Carotenoid_Oase", "pathway_ids": ["R-MMU-975634", "R-DME-975634", "R-DME-2453902", "R-GGA-975634", "R-MMU-2453902", "R-BTA-2453902", "R-DRE-2453902", "R-RNO-975634", "R-RNO-2453902", "R-HSA-975634", "R-HSA-2453902"], "pathways": ["R-MMU-975634:r:Retinoid metabolism and transport", "R-DME-975634:r:Retinoid metabolism and transport", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-GGA-975634:r:Retinoid metabolism and transport", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DRE-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Family"}, "IPR004296": {"description": "DUF236 repeat", "go_ids": [], "go_terms": [], "name": "DUF236", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR004297": {"description": "Systemic acquired resistance protein SAR", "go_ids": [], "go_terms": [], "name": "Sar8_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004298": {"description": "Nicotianamine synthase", "go_ids": ["GO:0030410", "GO:0030418"], "go_terms": ["GO:0030410:nicotianamine synthase activity:F", "GO:0030418:nicotianamine biosynthetic process:P"], "name": "Nicotian_synth", "pathway_ids": ["PWY-5957", "PWY-5912"], "pathways": ["PWY-5957:t:L-nicotianamine biosynthesis", "PWY-5912:t:2'-deoxymugineic acid phytosiderophore biosynthesis"], "type": "Family"}, "IPR004299": {"description": "Membrane bound O-acyl transferase, MBOAT", "go_ids": [], "go_terms": [], "name": "MBOAT_fam", "pathway_ids": ["R-HSA-6798695", "R-MMU-75109", "R-GGA-1482839", "R-GGA-1482788", "R-HSA-5340573", "R-DME-1482839", "R-SPO-1482839", "R-RNO-1482883", "R-RNO-8964038", "R-DME-1482788", "R-DDI-1482883", "R-HSA-8964038", "R-MMU-422085", "R-RNO-1482788", "R-HSA-1482922", "R-MMU-5358346", "R-HSA-75109", "R-MMU-8964038", "R-SCE-1482839", "R-MMU-1482788", "R-RNO-422085", "R-SCE-1482922", "R-RNO-1482801", "R-RNO-1482839", "R-CEL-1482801", "R-DDI-6798695", "R-CEL-1482839", "R-HSA-3238698", "R-RNO-75109", "R-DRE-1482922", "R-MMU-1482839", "R-HSA-422085", "R-DME-1482801", "R-HSA-1482801", "R-DME-209471", "R-DME-1482922", "R-SCE-1482801", "R-SPO-1482922", "R-DDI-75109", "R-MMU-1482922", "R-SPO-1482788", "R-MMU-1482883", "R-HSA-1482839", "R-DRE-422085", "R-HSA-1482883", "R-MMU-6798695", "R-BTA-1482922", "R-CEL-1482922", "R-HSA-5658034", "R-CEL-1482788", "R-SPO-1482801", "R-MMU-1482801", "R-DME-5358346", "R-SCE-1482788", "R-RNO-6798695", "R-HSA-5358346", "R-HSA-1482788"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-75109:r:Triglyceride biosynthesis", "R-GGA-1482839:r:Acyl chain remodelling of PE", "R-GGA-1482788:r:Acyl chain remodelling of PC", "R-HSA-5340573:r:LGK974 inhibits PORCN", "R-DME-1482839:r:Acyl chain remodelling of PE", "R-SPO-1482839:r:Acyl chain remodelling of PE", "R-RNO-1482883:r:Acyl chain remodeling of DAG and TAG", "R-RNO-8964038:r:LDL clearance", "R-DME-1482788:r:Acyl chain remodelling of PC", "R-DDI-1482883:r:Acyl chain remodeling of DAG and TAG", "R-HSA-8964038:r:LDL clearance", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-MMU-8964038:r:LDL clearance", "R-SCE-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-SCE-1482922:r:Acyl chain remodelling of PI", "R-RNO-1482801:r:Acyl chain remodelling of PS", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-CEL-1482801:r:Acyl chain remodelling of PS", "R-DDI-6798695:r:Neutrophil degranulation", "R-CEL-1482839:r:Acyl chain remodelling of PE", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-75109:r:Triglyceride biosynthesis", "R-DRE-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-DME-1482801:r:Acyl chain remodelling of PS", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-DME-1482922:r:Acyl chain remodelling of PI", "R-SCE-1482801:r:Acyl chain remodelling of PS", "R-SPO-1482922:r:Acyl chain remodelling of PI", "R-DDI-75109:r:Triglyceride biosynthesis", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-SPO-1482788:r:Acyl chain remodelling of PC", "R-MMU-1482883:r:Acyl chain remodeling of DAG and TAG", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-DRE-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-1482883:r:Acyl chain remodeling of DAG and TAG", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-CEL-1482922:r:Acyl chain remodelling of PI", "R-HSA-5658034:r:HHAT G278V doesn't palmitoylate Hh-Np", "R-CEL-1482788:r:Acyl chain remodelling of PC", "R-SPO-1482801:r:Acyl chain remodelling of PS", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-SCE-1482788:r:Acyl chain remodelling of PC", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Family"}, "IPR004300": {"description": "Glycoside hydrolase family 57, N-terminal domain", "go_ids": ["GO:0003824", "GO:0005975"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_57_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004301": {"description": "Nucleoplasmin family", "go_ids": [], "go_terms": [], "name": "Nucleoplasmin", "pathway_ids": ["R-HSA-606279", "R-HSA-9821993", "R-HSA-6804115", "R-HSA-9700645", "R-HSA-9833482", "R-MMU-3899300", "R-RNO-606279", "R-MMU-606279", "R-MMU-8869496", "R-RNO-6804115", "R-DME-9833482", "R-MMU-9833482", "R-HSA-9725371", "R-HSA-8869496", "R-RNO-8869496", "R-DME-3899300", "R-MMU-6804115", "R-HSA-3899300", "R-HSA-180746", "R-HSA-9692914", "R-HSA-9725370", "R-RNO-9833482", "R-DME-8869496", "R-RNO-3899300"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-180746:r:Nuclear import of Rev protein", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-3899300:r:SUMOylation of transcription cofactors"], "type": "Family"}, "IPR004302": {"description": "Cellulose/chitin-binding protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Cellulose/chitin-bd_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004303": {"description": "Protein-arginine deiminase", "go_ids": ["GO:0004668"], "go_terms": ["GO:0004668:protein-arginine deiminase activity:F"], "name": "PAD", "pathway_ids": ["PWY-4921", "R-MMU-6798695", "R-HSA-6798695", "R-RNO-3247509", "R-RNO-6798695", "R-MMU-3247509", "R-HSA-3247509"], "pathways": ["PWY-4921:t:protein citrullination", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-HSA-3247509:r:Chromatin modifying enzymes"], "type": "Family"}, "IPR004304": {"description": "Acetamidase/Formamidase", "go_ids": ["GO:0016811"], "go_terms": ["GO:0016811:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides:F"], "name": "FmdA_AmdA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004305": {"description": "Thiaminase-2/PQQC", "go_ids": [], "go_terms": [], "name": "Thiaminase-2/PQQC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004306": {"description": "Domain of unknown function DUF237", "go_ids": [], "go_terms": [], "name": "DUF237", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004307": {"description": "TspO/MBR-related protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TspO_MBR", "pathway_ids": ["R-MMU-196108", "R-HSA-196108", "R-RNO-196108"], "pathways": ["R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-RNO-196108:r:Pregnenolone biosynthesis"], "type": "Family"}, "IPR004308": {"description": "Glutamate-cysteine ligase catalytic subunit", "go_ids": ["GO:0004357", 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["PWY-4361:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I", "PWY-5389:t:3-methylthiopropanoate biosynthesis", "R-DRE-1237112:r:Methionine salvage pathway", "R-SCE-1237112:r:Methionine salvage pathway", "R-BTA-1237112:r:Methionine salvage pathway", "R-GGA-1237112:r:Methionine salvage pathway", "R-SPO-1237112:r:Methionine salvage pathway", "R-RNO-1237112:r:Methionine salvage pathway", "R-MMU-1237112:r:Methionine salvage pathway", "R-DDI-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-HSA-1237112:r:Methionine salvage pathway"], "type": "Family"}, "IPR004314": {"description": "Neprosin", "go_ids": [], "go_terms": [], "name": "Neprosin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004315": {"description": "Male Drosophila accessory gland secretory protein", "go_ids": ["GO:0005576", "GO:0007618"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0007618:mating:P"], "name": "Male_ac_gland_sc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004316": {"description": "Sugar transporter SWEET repeat", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "SWEET_rpt", "pathway_ids": ["R-MMU-189200", "R-RNO-189200", "R-HSA-189200", "R-DRE-189200", "R-DDI-189200"], "pathways": ["R-MMU-189200:r:Cellular hexose transport", "R-RNO-189200:r:Cellular hexose transport", "R-HSA-189200:r:Cellular hexose transport", "R-DRE-189200:r:Cellular hexose transport", "R-DDI-189200:r:Cellular hexose transport"], "type": "Repeat"}, "IPR004317": {"description": "Sigma1/sigma2, reoviral", "go_ids": [], "go_terms": [], "name": "Sigma_1_2_reovir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004318": {"description": "Rhoptry-associated protein 1", "go_ids": [], "go_terms": [], "name": "RAP-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004319": {"description": "Domain of unknown function DUF240", "go_ids": [], "go_terms": [], "name": "DUF240", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004320": {"description": "Protein BPS1, chloroplastic", "go_ids": ["GO:0048367", "GO:0048364"], "go_terms": ["GO:0048367:shoot system development:P", "GO:0048364:root development:P"], "name": "BPS1_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004321": {"description": "V-D-J recombination activating protein 2", "go_ids": ["GO:0003677", "GO:0005634", "GO:0006310"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006310:DNA recombination:P"], "name": "RAG2", "pathway_ids": ["R-HSA-1266695", "R-HSA-5687128"], "pathways": ["R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Family"}, "IPR004322": {"description": "Plasmid replicase, bacterial", "go_ids": [], "go_terms": [], "name": "Plasmid_replicase_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004323": {"description": "Divalent ion tolerance protein, CutA", "go_ids": ["GO:0010038"], "go_terms": ["GO:0010038:response to metal ion:P"], "name": "Ion_tolerance_CutA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004324": {"description": "Folate-biopterin transporter", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "FBT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004326": {"description": "Mlo-related protein", "go_ids": ["GO:0016020", "GO:0006952"], "go_terms": ["GO:0016020:membrane:C", "GO:0006952:defense response:P"], "name": "Mlo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004327": {"description": "Phosphotyrosyl phosphatase activator, PTPA", "go_ids": ["GO:0019211"], "go_terms": ["GO:0019211:phosphatase activator activity:F"], "name": "Phstyr_phstse_ac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004328": {"description": "BRO1 domain", "go_ids": [], "go_terms": [], "name": "BRO1_dom", "pathway_ids": ["R-BTA-5666185", "R-MMU-8980692", "R-HSA-5666185", "R-HSA-5675482", "R-MMU-5675482", "R-HSA-162588", "R-HSA-5213460", "R-HSA-9008059", "R-MMU-5213460", "R-HSA-8980692", "R-DDI-5213460", "R-MMU-9013026", "R-DRE-5666185", "R-DRE-9013026", "R-BTA-8980692", "R-DRE-8980692", "R-HSA-9013026", "R-RNO-5213460", "R-HSA-5210891", "R-RNO-5675482", "R-HSA-9918481", "R-MMU-5666185"], "pathways": ["R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins"], "type": "Domain"}, "IPR004329": {"description": "CcmE/CycJ protein", "go_ids": ["GO:0017003", "GO:0017004", "GO:0020037"], "go_terms": ["GO:0017003:protein-heme linkage:P", "GO:0017004:cytochrome complex assembly:P", "GO:0020037:heme binding:F"], "name": "CcmE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004330": {"description": "FAR1, DNA binding domain", "go_ids": [], "go_terms": [], "name": "FAR1_DNA_bnd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004331": {"description": "SPX domain", "go_ids": [], "go_terms": [], "name": "SPX_dom", "pathway_ids": ["R-SCE-204005", "R-SCE-983168", "R-SCE-3295583"], "pathways": ["R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-3295583:r:TRP channels"], "type": "Domain"}, "IPR004332": {"description": "Transposase, MuDR, plant", "go_ids": [], "go_terms": [], "name": "Transposase_MuDR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004333": {"description": "SBP domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "SBP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004334": {"description": "Poxvirus E5R", "go_ids": [], "go_terms": [], "name": "Poxvirus_E5R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004335": {"description": "Protein of unknown function DUF244", "go_ids": [], "go_terms": [], "name": "DUF244", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004336": {"description": "Non-structural protein 2, orthopneumovirus", "go_ids": [], "go_terms": [], "name": "NS2_orthopneumovirus", "pathway_ids": ["R-HSA-9828721", "R-HSA-9833110", "R-HSA-9828806", "R-HSA-9833109"], "pathways": ["R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9833109:r:Evasion by RSV of host interferon responses"], "type": "Family"}, "IPR004337": {"description": "Astrovirus capsid protein, inner core domain", "go_ids": [], "go_terms": [], "name": "Astro_capsid_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004338": {"description": "Ion-translocating oxidoreductase NqrB/RnfD", "go_ids": ["GO:0016020", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "NqrB/RnfD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004339": {"description": "UL49-related protein", "go_ids": ["GO:0016032", "GO:0019033"], "go_terms": ["GO:0016032:viral process:P", "GO:0019033:viral tegument:C"], "name": "UL49", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004341": {"description": "CAT RNA-binding domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "CAT_RNA-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004342": {"description": "EXS, C-terminal", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "EXS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004343": {"description": "Plus-3 domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Plus-3_dom", "pathway_ids": ["R-HSA-8866654", "R-HSA-674695", "R-HSA-75955", "R-HSA-9920588", "R-HSA-112382"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR004344": {"description": "Tubulin-tyrosine ligase/Tubulin polyglutamylase", "go_ids": ["GO:0036211"], "go_terms": ["GO:0036211:protein modification process:P"], "name": "TTL/TTLL_fam", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565", "R-RNO-8955332", "R-HSA-8955332", "R-MMU-8955332"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "R-RNO-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-MMU-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Family"}, "IPR004345": {"description": "TB2/DP1/HVA22", "go_ids": [], "go_terms": [], "name": "TB2_DP1_HVA22", "pathway_ids": ["R-HSA-9752946"], "pathways": ["R-HSA-9752946:r:Expression and translocation of olfactory receptors"], "type": "Family"}, "IPR004346": {"description": "Type IV secretion system ATPase VirB4/TrbE", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "VirB4_CagE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004347": {"description": "Pup ligase/deamidase", "go_ids": ["GO:0019941", "GO:0010498"], "go_terms": ["GO:0019941:modification-dependent protein catabolic process:P", "GO:0010498:proteasomal protein catabolic process:P"], "name": "Pup_ligase/deamidase", "pathway_ids": ["PWY-7893"], "pathways": ["PWY-7893:t:protein Pupylation and dePupylation"], "type": "Family"}, "IPR004349": {"description": "Vanadium/alternative nitrogenase delta subunit", "go_ids": ["GO:0009399", "GO:0016163"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F"], "name": "V/Nase_d_su", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004352": {"description": "Glycoside-hydrolase family GH114, TIM-barrel domain", "go_ids": [], "go_terms": [], "name": "GH114_TIM-barrel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004353": {"description": "Vacuolar fusion protein Mon1", "go_ids": ["GO:0006623"], "go_terms": ["GO:0006623:protein targeting to vacuole:P"], "name": "Mon1", "pathway_ids": ["R-GGA-8876198", "R-BTA-8876198", "R-HSA-8876198", "R-MMU-8876198", "R-SCE-8876198", "R-DME-8876198"], "pathways": ["R-GGA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR004354": {"description": "Meiotic recombination protein Rec114", "go_ids": ["GO:0007131"], "go_terms": ["GO:0007131:reciprocal meiotic recombination:P"], "name": "Meiotic_Rec114", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004356": {"description": "Adhesin operon regulatory protein", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Adhesin_operon_reg_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004360": {"description": "Glyoxalase/fosfomycin resistance/dioxygenase domain", "go_ids": [], "go_terms": [], "name": "Glyas_Fos-R_dOase_dom", "pathway_ids": ["R-MMU-70268", "R-HSA-8963684", "R-BTA-8963684", "R-RNO-70268", "R-RNO-8963684", "R-DDI-2142789", "R-SPO-70268", "R-MMU-8963684", "R-CEL-8963684", "R-DDI-8963684", "R-HSA-70268", "R-SCE-70268"], "pathways": ["R-MMU-70268:r:Pyruvate metabolism", "R-HSA-8963684:r:Tyrosine catabolism", "R-BTA-8963684:r:Tyrosine catabolism", "R-RNO-70268:r:Pyruvate metabolism", "R-RNO-8963684:r:Tyrosine catabolism", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-SPO-70268:r:Pyruvate metabolism", "R-MMU-8963684:r:Tyrosine catabolism", "R-CEL-8963684:r:Tyrosine catabolism", "R-DDI-8963684:r:Tyrosine catabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Domain"}, "IPR004361": {"description": "Glyoxalase I", "go_ids": ["GO:0004462", "GO:0046872"], "go_terms": ["GO:0004462:lactoylglutathione lyase activity:F", "GO:0046872:metal ion binding:F"], "name": "Glyoxalase_1", "pathway_ids": ["PWY-5386", "R-MMU-70268", "R-RNO-70268", "R-SPO-70268", "R-HSA-70268", "R-SCE-70268"], "pathways": ["PWY-5386:t:methylglyoxal degradation I", "R-MMU-70268:r:Pyruvate metabolism", "R-RNO-70268:r:Pyruvate metabolism", "R-SPO-70268:r:Pyruvate metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Family"}, "IPR004363": {"description": "Methylglyoxal synthase", "go_ids": ["GO:0008929", "GO:0019242"], "go_terms": ["GO:0008929:methylglyoxal synthase activity:F", "GO:0019242:methylglyoxal biosynthetic process:P"], "name": "Methylgl_synth", 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and activity", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SPO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR004365": {"description": "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "NA-bd_OB_tRNA", "pathway_ids": ["R-MMU-9856649", "R-HSA-5693616", "R-SPO-5656169", "R-GGA-174437", "R-HSA-5696397", "R-GGA-110314", "R-SPO-5656121", "R-MMU-110320", "R-MMU-6804756", "R-GGA-351468", "R-HSA-5655862", "R-MMU-5685938", "R-MMU-110314", "R-MMU-69473", "R-MMU-5696395", "R-SPO-5696395", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-MMU-174437", "R-SPO-9856649", "R-GGA-6782135", "R-CEL-9856649", "R-HSA-5656121", "R-GGA-5696400", "R-MMU-5358606", "R-MMU-5358565", "R-SPO-69166", "R-GGA-68962", "R-DRE-6804756", "R-SPO-176187", "R-DRE-6782210", "R-GGA-110320", "R-HSA-69473", "R-MMU-5651801", "R-MMU-68962", "R-HSA-174430", "R-DRE-5685942", "R-HSA-110312", "R-GGA-6782210", "R-HSA-6783310", "R-DRE-3371453", "R-DRE-174437", "R-GGA-110312", "R-GGA-5656169", "R-HSA-6804756", "R-HSA-2408522", "R-GGA-5358565", "R-GGA-5651801", "R-DRE-69473", "R-HSA-5696395", "R-DRE-5358565", "R-SPO-110314", "R-MMU-176187", "R-MMU-6782210", "R-MMU-3108214", "R-GGA-5693607", "R-MMU-5696397", "R-GGA-176187", "R-SCE-6782135", "R-HSA-110314", "R-SPO-5651801", "R-HSA-3371511", "R-HSA-379726", "R-DRE-5358606", "R-GGA-5685938", "R-DRE-5693607", "R-DRE-176187", "R-HSA-3108214", "R-HSA-5685942", "R-GGA-3108214", "R-GGA-5685942", "R-MMU-6782135", "R-GGA-5358606", "R-SCE-9856649", "R-HSA-5358606", "R-DRE-5656121", 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"pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004374": {"description": "Peptide chain release factor 2", "go_ids": ["GO:0005737", "GO:0006415", "GO:0016149"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006415:translational termination:P", "GO:0016149:translation release factor activity, codon specific:F"], "name": "PrfB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004375": {"description": "NanQ anomerase/TabA/YiaL family", "go_ids": [], "go_terms": [], "name": "NanQ/TabA/YiaL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004376": {"description": "Phosphoesterase MJ0037", "go_ids": [], "go_terms": [], "name": "Pesterase_MJ0037", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004377": {"description": "ABC transporter, permease protein DrrB/DrrC", "go_ids": ["GO:0043215", "GO:1900753", "GO:0046677"], "go_terms": ["GO:0043215:daunorubicin transport:P", "GO:1900753:doxorubicin transport:P", "GO:0046677:response to antibiotic:P"], "name": "ABC_transpt_DrrB/DrrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004378": {"description": "F420H(2)-dependent quinone reductase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "F420H2_quin_Rdtase", "pathway_ids": ["PWY-5923", "PWY-5927", "PWY-5922", "PWY-5924", "PWY-8445"], "pathways": ["PWY-5923:t:limonene degradation I (D-limonene)", "PWY-5927:t:(4S)-carveol and (4S)-dihydrocarveol degradation", "PWY-5922:t:(4R)-carveol and (4R)-dihydrocarveol degradation", "PWY-5924:t:limonene degradation II (L-limonene)", "PWY-8445:t:puerarin degradation"], "type": "Family"}, "IPR004379": {"description": "UDP-galactopyranose mutase", "go_ids": ["GO:0008767"], "go_terms": ["GO:0008767:UDP-galactopyranose mutase activity:F"], "name": "UDP-GALP_mutase", "pathway_ids": ["PWY-7328", "PWY-7622", "PWY-6397"], "pathways": ["PWY-7328:t:superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis", "PWY-7622:t:UDP-alpha-D-galactofuranose biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"], "type": "Family"}, "IPR004380": {"description": "Aspartate racemase", "go_ids": ["GO:0047661"], "go_terms": ["GO:0047661:amino-acid racemase activity:F"], "name": "Asp_race", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004381": {"description": "Glycerate kinase", "go_ids": ["GO:0008887"], "go_terms": ["GO:0008887:glycerate kinase activity:F"], "name": "Glycerate_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004383": {"description": "Ribosomal RNA large subunit methyltransferase RlmN/Cfr", "go_ids": ["GO:0006364", "GO:0008173"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0008173:RNA methyltransferase activity:F"], "name": "rRNA_lsu_MTrfase_RlmN/Cfr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004384": {"description": "RNA methyltransferase TrmJ/LasT", "go_ids": ["GO:0006396", "GO:0008173"], "go_terms": ["GO:0006396:RNA processing:P", "GO:0008173:RNA methyltransferase activity:F"], "name": "RNA_MeTrfase_TrmJ/LasT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004385": {"description": "Nucleoside diphosphate pyrophosphatase", "go_ids": ["GO:0016818", "GO:0046872"], "go_terms": ["GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F", "GO:0046872:metal ion binding:F"], "name": "NDP_pyrophosphatase", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-BTA-480985", "R-MMU-480985", "R-SSC-480985", "R-HSA-480985"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin 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"name": "Pept_M50_Zn", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR004389": {"description": "Large ribosomal subunit protein uL18, bacteria", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uL18_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004390": {"description": "Signal-recognition particle receptor FtsY", "go_ids": ["GO:0006614"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P"], "name": "SR_rcpt_FtsY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004391": {"description": "Glutamate racemase", "go_ids": ["GO:0008881"], "go_terms": ["GO:0008881:glutamate racemase activity:F"], "name": "Glu_race", "pathway_ids": ["PWY-6387", "PWY-6386"], "pathways": ["PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "type": "Family"}, "IPR004392": {"description": "Hydrogenase maturation factor HypB", "go_ids": ["GO:0016151", "GO:0003924", "GO:0051604"], "go_terms": ["GO:0016151:nickel cation binding:F", "GO:0003924:GTPase activity:F", "GO:0051604:protein maturation:P"], "name": "Hyd_mat_HypB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004393": {"description": "Nicotinate-nucleotide pyrophosphorylase", "go_ids": ["GO:0004514", "GO:0009435"], "go_terms": ["GO:0004514:nicotinate-nucleotide diphosphorylase (carboxylating) activity:F", "GO:0009435:NAD+ biosynthetic process:P"], "name": "NadC", "pathway_ids": ["PWY-7342", "PWY-8277", "PWY-5653", "PWY-5316", "PWY-8352", "R-MMU-196807", "R-HSA-196807", "R-DDI-196807", "R-RNO-196807", "R-SSC-196807", "R-SCE-196807"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-8277:t:NAD de novo biosynthesis IV (anaerobic)", "PWY-5653:t:NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde", "PWY-5316:t:nicotine biosynthesis", "PWY-8352:t:NAD de novo biosynthesis III", "R-MMU-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-SSC-196807:r:Nicotinate metabolism", "R-SCE-196807:r:Nicotinate metabolism"], "type": "Family"}, "IPR004394": {"description": "Protein Iojap/ribosomal silencing factor RsfS", "go_ids": [], "go_terms": [], "name": "Iojap/RsfS/C7orf30", "pathway_ids": ["R-HSA-9937383", "R-MMU-9937383"], "pathways": ["R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR004396": {"description": "Ribosome-binding ATPase YchF/Obg-like ATPase 1", "go_ids": ["GO:0005525", "GO:0005524", "GO:0016887"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0005524:ATP binding:F", "GO:0016887:ATP hydrolysis activity:F"], "name": "ATPase_YchF/OLA1", "pathway_ids": ["R-HSA-114608", "R-BTA-114608", "R-DRE-114608", "R-DME-114608", "R-CEL-114608", "R-SCE-114608", "R-GGA-114608", "R-SPO-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-DME-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-SCE-114608:r:Platelet degranulation", "R-GGA-114608:r:Platelet degranulation", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR004398": {"description": "RNA methyltransferase, RsmD", "go_ids": ["GO:0008168", "GO:0031167"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0031167:rRNA methylation:P"], "name": "RNA_MeTrfase_RsmD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004399": {"description": "Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase domain", "go_ids": ["GO:0008972", "GO:0009228"], "go_terms": ["GO:0008972:phosphomethylpyrimidine kinase activity:F", "GO:0009228:thiamine biosynthetic process:P"], "name": "HMP/HMP-P_kinase_dom", "pathway_ids": ["PWY-7282", "PWY-6910", "PWY-7356", "PWY-6890", "PWY-7357"], "pathways": ["PWY-7282:t:4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II", "PWY-6910:t:hydroxymethylpyrimidine salvage", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "PWY-6890:t:4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I", "PWY-7357:t:thiamine diphosphate formation from pyrithiamine and oxythiamine (yeast)"], "type": "Domain"}, "IPR004400": {"description": "Urease accessory protein UreG", "go_ids": ["GO:0016151", "GO:0003924", "GO:0043419"], "go_terms": ["GO:0016151:nickel cation binding:F", "GO:0003924:GTPase activity:F", "GO:0043419:urea catabolic process:P"], "name": "UreG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004401": {"description": "Nucleoid-associated protein YbaB/EbfC", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "YbaB/EbfC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004402": {"description": "Purine nucleoside phosphorylase DeoD-type", "go_ids": ["GO:0004731", "GO:0006139"], "go_terms": ["GO:0004731:purine-nucleoside phosphorylase activity:F", "GO:0006139:nucleobase-containing compound metabolic process:P"], "name": "DeoD-type", "pathway_ids": ["PWY-4202", "PWY-5695", "PWY-6611", "PWY-7179", "PWY-6608", "PWY-6609", "PWY-5532", "PWY-6627", "PWY-8440", "PWY-6620", "PWY-6644"], "pathways": ["PWY-4202:t:arsenic detoxification (mammals)", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6611:t:adenine and adenosine salvage V", "PWY-7179:t:purine deoxyribonucleosides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6609:t:adenine and adenosine salvage III", "PWY-5532:t:nucleoside and nucleotide degradation (archaea)", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8440:t:nucleoside and nucleotide degradation (halobacteria)", "PWY-6620:t:guanine and guanosine salvage I", "PWY-6644:t:fluoroacetate and fluorothreonine biosynthesis"], "type": "Family"}, "IPR004403": {"description": "Peptide chain release factor eRF1/aRF1", "go_ids": ["GO:0006415", "GO:0003747"], "go_terms": ["GO:0006415:translational termination:P", "GO:0003747:translation release factor activity:F"], "name": "Peptide_chain-rel_eRF1/aRF1", "pathway_ids": ["R-RNO-9629569", "R-DDI-975956", "R-BTA-975957", "R-CEL-975957", "R-SPO-72764", "R-HSA-9010553", "R-CEL-9629569", "R-XTR-975956", "R-SPO-975957", "R-CEL-72764", "R-HSA-975956", "R-XTR-975957", "R-CEL-975956", "R-DME-72764", "R-SCE-975957", "R-BTA-72764", "R-SCE-72764", "R-MMU-975956", "R-HSA-9629569", "R-RNO-975957", "R-MMU-72764", "R-SPO-975956", "R-DME-975956", "R-SCE-975956", "R-SPO-9629569", "R-MMU-975957", "R-DME-9629569", "R-DDI-72764", "R-HSA-72764", "R-HSA-975957", "R-MMU-9629569", "R-XTR-72764", "R-RNO-975956", "R-BTA-975956", "R-DDI-975957", "R-XTR-9629569", "R-BTA-9629569", "R-DME-975957"], "pathways": ["R-RNO-9629569:r:Protein hydroxylation", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72764:r:Eukaryotic Translation Termination", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-9629569:r:Protein hydroxylation", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-72764:r:Eukaryotic Translation Termination", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-XTR-975957:r:Nonsense 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"GO:0009082"], "go_terms": ["GO:0004160:dihydroxy-acid dehydratase activity:F", "GO:0009082:branched-chain amino acid biosynthetic process:P"], "name": "DihydroxyA_deHydtase", "pathway_ids": ["PWY-7111", "PWY-5101", "PWY-5103", "PWY-5104"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-5103:t:L-isoleucine biosynthesis III", "PWY-5104:t:L-isoleucine biosynthesis IV"], "type": "Family"}, "IPR004405": {"description": "Pelota", "go_ids": ["GO:0070481", "GO:0071025", "GO:0070966"], "go_terms": ["GO:0070481:nuclear-transcribed mRNA catabolic process, non-stop decay:P", "GO:0071025:RNA surveillance:P", "GO:0070966:nuclear-transcribed mRNA catabolic process, no-go decay:P"], "name": "TF_pelota", "pathway_ids": ["R-DRE-9954714", "R-DME-9954714", "R-SPO-9954714", "R-SCE-9954714", "R-CEL-9954714", "R-RNO-9954714", "R-MMU-9954714", "R-HSA-9954714"], "pathways": ["R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome 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"type": "Family"}, "IPR004408": {"description": "Biotin--acetyl-CoA-carboxylase ligase", "go_ids": ["GO:0004077", "GO:0036211"], "go_terms": ["GO:0004077:biotin--[biotin carboxyl-carrier protein] ligase activity:F", "GO:0036211:protein modification process:P"], "name": "Biotin_CoA_COase_ligase", "pathway_ids": ["R-HSA-196780", "R-SPO-196780", "R-SCE-196780", "R-HSA-3371599", "R-MMU-196780"], "pathways": ["R-HSA-196780:r:Biotin transport and metabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-SCE-196780:r:Biotin transport and metabolism", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-196780:r:Biotin transport and metabolism"], "type": "Family"}, "IPR004409": {"description": "Biotin operon repressor, helix-turn-helix domain", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Biotin_operon_repress_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004410": {"description": "Malonyl CoA-acyl carrier protein transacylase, FabD-type", "go_ids": ["GO:0004314"], "go_terms": ["GO:0004314:[acyl-carrier-protein] S-malonyltransferase activity:F"], "name": "Malonyl_CoA-ACP_transAc_FabD", "pathway_ids": ["PWY-8049", "PWY-8012", "PWY-8438", "PWY-8047", "PWY-6799", "PWY-4381"], "pathways": ["PWY-8049:t:pederin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-4381:t:fatty acid biosynthesis initiation (type II)"], "type": "Family"}, "IPR004411": {"description": "Peptidase A31, coenzyme F420-reducing hydrogenase delta subunit", "go_ids": ["GO:0008233", "GO:0036211"], "go_terms": ["GO:0008233:peptidase activity:F", "GO:0036211:protein modification process:P"], "name": "Pept_A31_F420-red_hyd_d", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004412": {"description": "Glutamyl-tRNA(Gln) amidotransferase A subunit", "go_ids": ["GO:0006412", "GO:0030956", "GO:0050567"], "go_terms": ["GO:0006412:translation:P", "GO:0030956:glutamyl-tRNA(Gln) amidotransferase complex:C", "GO:0050567:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity:F"], "name": "GatA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004413": {"description": "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B", "go_ids": ["GO:0016884"], "go_terms": ["GO:0016884:carbon-nitrogen ligase activity, with glutamine as amido-N-donor:F"], "name": "GatB", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Family"}, "IPR004414": {"description": "Glutamyl-tRNA(Gln) amidotransferase subunit E", "go_ids": ["GO:0016884"], "go_terms": ["GO:0016884:carbon-nitrogen ligase activity, with glutamine as amido-N-donor:F"], "name": "GatE", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Family"}, "IPR004416": {"description": "tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG", "go_ids": ["GO:0002098"], "go_terms": ["GO:0002098:tRNA wobble uridine modification:P"], "name": "MnmG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004417": {"description": "Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO", "go_ids": ["GO:0005737", "GO:0008033", "GO:0047151", "GO:0050660"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008033:tRNA processing:P", "GO:0047151:tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "TrmFO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004418": {"description": "Homoaconitase, mitochondrial", "go_ids": ["GO:0004409", "GO:0009085", "GO:0051539"], "go_terms": ["GO:0004409:homoaconitate hydratase activity:F", "GO:0009085:L-lysine biosynthetic process:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Homoaconitase_mito", "pathway_ids": ["PWY-3081"], "pathways": ["PWY-3081:t:L-lysine biosynthesis V"], "type": "Family"}, "IPR004419": {"description": "Peptidase A31, hydrogenase expression/formation protein", "go_ids": ["GO:0016485", "GO:0046872"], "go_terms": ["GO:0016485:protein processing:P", "GO:0046872:metal ion binding:F"], "name": "Pept_A31_hyd_express", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004420": {"description": "Hydrogenase 3 maturation protease", "go_ids": ["GO:0008233"], "go_terms": ["GO:0008233:peptidase activity:F"], "name": "HycI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004421": {"description": "Carbamoyltransferase 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"go_ids": [], "go_terms": [], "name": "MJ0106-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004426": {"description": "Proteasome assembly chaperone MJ1210-like", "go_ids": [], "go_terms": [], "name": "MJ1210-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004429": {"description": "Isopropylmalate dehydrogenase", "go_ids": ["GO:0003862", "GO:0009098"], "go_terms": ["GO:0003862:3-isopropylmalate dehydrogenase activity:F", "GO:0009098:L-leucine biosynthetic process:P"], "name": "Isopropylmalate_DH", "pathway_ids": ["PWY-7396"], "pathways": ["PWY-7396:t:butanol and isobutanol biosynthesis (engineered)"], "type": "Family"}, "IPR004430": {"description": "3-isopropylmalate dehydratase, large subunit", "go_ids": ["GO:0003861", "GO:0009098", "GO:0051539"], "go_terms": ["GO:0003861:3-isopropylmalate dehydratase activity:F", "GO:0009098:L-leucine biosynthetic process:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "3-IsopropMal_deHydase_lsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004431": {"description": "3-isopropylmalate dehydratase, small subunit", "go_ids": ["GO:0003861", "GO:0009098", "GO:0009316"], "go_terms": ["GO:0003861:3-isopropylmalate dehydratase activity:F", "GO:0009098:L-leucine biosynthetic process:P", "GO:0009316:3-isopropylmalate dehydratase complex:C"], "name": "3-IsopropMal_deHydase_ssu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004432": {"description": "Polyketide-type polyunsaturated fatty acid synthase, PfaA", "go_ids": [], "go_terms": [], "name": "Omega_3_polyunsat_FA_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004433": {"description": "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase", "go_ids": ["GO:0009234", "GO:0030976", "GO:0070204"], "go_terms": ["GO:0009234:menaquinone biosynthetic process:P", "GO:0030976:thiamine pyrophosphate binding:F", "GO:0070204:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity:F"], "name": "MenaQ_synth_MenD", "pathway_ids": ["PWY-5837"], "pathways": ["PWY-5837:t:2-carboxy-1,4-naphthoquinol biosynthesis"], "type": "Family"}, "IPR004434": {"description": "Isocitrate dehydrogenase NAD-dependent", "go_ids": ["GO:0006099"], "go_terms": ["GO:0006099:tricarboxylic acid cycle:P"], "name": "Isocitrate_DH_NAD", "pathway_ids": ["R-MMU-9837999", "R-SPO-71403", "R-CEL-71403", "R-CEL-9837999", "R-HSA-1268020", "R-MMU-71403", "R-BTA-71403", "R-SCE-71403", "R-DME-9837999", "R-DME-71403", "R-HSA-9837999", "R-DDI-71403", "R-RNO-71403", "R-RNO-9837999", "R-HSA-71403"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Family"}, "IPR004435": {"description": "Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB) domain", "go_ids": ["GO:0005525", "GO:0006777"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0006777:Mo-molybdopterin cofactor biosynthetic process:P"], "name": "MobB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004436": {"description": "Isocitrate dehydrogenase NADP-dependent, monomeric", "go_ids": ["GO:0004450", "GO:0006099"], "go_terms": ["GO:0004450:isocitrate dehydrogenase (NADP+) activity:F", 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"pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR004439": {"description": "Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic", "go_ids": ["GO:0004450", "GO:0006099"], "go_terms": ["GO:0004450:isocitrate dehydrogenase (NADP+) activity:F", "GO:0006099:tricarboxylic acid cycle:P"], "name": "Isocitrate_DH_NADP_dimer_prok", "pathway_ids": ["PWY-6549", "PWY-7254", "PWY-7124", "PWY-5913", "PWY-7268", "PWY-6728", "PWY-6969"], "pathways": ["PWY-6549:t:nitrogen remobilization from senescing leaves", "PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7268:t:cytosolic NADPH production (yeast)", "PWY-6728:t:methylaspartate cycle", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)"], "type": "Family"}, "IPR004441": {"description": "RNA methyltransferase TrmH", "go_ids": ["GO:0006396", "GO:0008173"], "go_terms": ["GO:0006396:RNA 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"R-DRE-196807:r:Nicotinate metabolism", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SCE-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-CEL-196807:r:Nicotinate metabolism", "R-PFA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR004445": {"description": "Sodium/glutamate symport carrier protein GltS", "go_ids": ["GO:0015501", "GO:0015813", "GO:0016020"], "go_terms": ["GO:0015501:glutamate:sodium symporter activity:F", "GO:0015813:L-glutamate transmembrane transport:P", "GO:0016020:membrane:C"], "name": "GltS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004446": {"description": "D,D-heptose 1,7-bisphosphate phosphatase", "go_ids": ["GO:0005975", "GO:0016791"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", 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"PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR004450": {"description": "Threonine synthase-like", "go_ids": [], "go_terms": [], "name": "Thr_synthase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004451": {"description": "MJ0586", "go_ids": [], "go_terms": [], "name": "MJ0586", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004452": {"description": "L-lactate oxidation iron-sulfur protein LutB/LldF", "go_ids": ["GO:0006089"], "go_terms": ["GO:0006089:lactate metabolic process:P"], "name": "LutB/LldF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004453": {"description": "Epoxyqueuosine reductase QueG", "go_ids": ["GO:0008616", "GO:0008033", "GO:0016491"], "go_terms": ["GO:0008616:tRNA queuosine(34) biosynthetic process:P", "GO:0008033:tRNA processing:P", "GO:0016491:oxidoreductase activity:F"], "name": "QueG", "pathway_ids": ["PWY-6700", "PWY-8106"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Family"}, "IPR004454": {"description": "HD-related protein", "go_ids": [], "go_terms": [], "name": "HD-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004456": {"description": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase", "go_ids": ["GO:0003824", "GO:0004619"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0004619:phosphoglycerate mutase activity:F"], "name": "Pglycerate_mutase_ApgM", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-2221", "PWY-7124", "PWY-6886", "PWY-6142", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901", "PWY-5484", "PWY-8362"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-8362:t:photorespiration II"], "type": "Family"}, "IPR004457": {"description": "Zinc finger, ZPR1-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_ZPR1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004458": {"description": "Translation initiation factor 2, beta subunit", "go_ids": ["GO:0003743", "GO:0006413"], "go_terms": ["GO:0003743:translation initiation factor activity:F", "GO:0006413:translational initiation:P"], "name": "TIF2_bsu_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004459": {"description": "Cobyric acid synthase CobQ", "go_ids": ["GO:0003824", "GO:0009236"], 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nucleotide di- and triphosphates", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR004469": {"description": "Phosphoserine phosphatase", "go_ids": ["GO:0006564", "GO:0036424"], "go_terms": ["GO:0006564:L-serine biosynthetic process:P", "GO:0036424:L-phosphoserine phosphatase activity:F"], "name": "PSP", "pathway_ids": ["R-MMU-977347", "R-RNO-977347", "R-HSA-977347", "R-DME-977347", "R-SPO-977347", "R-BTA-977347", "R-SCE-977347"], "pathways": ["R-MMU-977347:r:Serine metabolism", "R-RNO-977347:r:Serine metabolism", "R-HSA-977347:r:Serine metabolism", "R-DME-977347:r:Serine metabolism", "R-SPO-977347:r:Serine metabolism", "R-BTA-977347:r:Serine metabolism", "R-SCE-977347:r:Serine metabolism"], "type": "Family"}, "IPR004470": {"description": "ZPR1-like, archaea", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "ZPR1-like_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004471": {"description": "Branched-chain amino acid transport, AzlC", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Brnchd-chn_aa_trnsp_AzlC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004472": {"description": "Dethiobiotin synthase BioD", "go_ids": ["GO:0000287", "GO:0004141", "GO:0005524", "GO:0009102"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0004141:dethiobiotin synthase activity:F", "GO:0005524:ATP binding:F", "GO:0009102:biotin biosynthetic process:P"], "name": "DTB_synth_BioD", "pathway_ids": ["PWY-7380"], "pathways": ["PWY-7380:t:biotin biosynthesis from 8-amino-7-oxononanoate II"], "type": "Family"}, "IPR004473": {"description": "Restriction endonuclease, type I, HsdR", "go_ids": ["GO:0003677", "GO:0005524", "GO:0009035", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F", "GO:0009035:type I site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_typeI_HsdR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004474": {"description": "Cell envelope-related transcriptional attenuator domain", "go_ids": [], "go_terms": [], "name": "LytR_CpsA_psr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004475": {"description": "DNA polymerase II large subunit DP2", "go_ids": ["GO:0003677", "GO:0003887", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P"], "name": "PolC_DP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004476": {"description": "Ribonuclease II/ribonuclease R", "go_ids": ["GO:0003723", "GO:0004540", "GO:0016070"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0004540:RNA nuclease activity:F", "GO:0016070:RNA metabolic process:P"], "name": "RNase_II/RNase_R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004477": {"description": "ComEC/Rec2-related protein", "go_ids": [], "go_terms": [], "name": "ComEC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004480": {"description": "Monothiol glutaredoxin-related", "go_ids": [], "go_terms": [], "name": "Monothiol_GRX-rel", "pathway_ids": ["R-HSA-1362409", "R-DDI-1362409", "R-SCE-1362409", "R-HSA-917937", "R-MMU-1362409", "R-SPO-1362409"], "pathways": ["R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DDI-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-917937:r:Iron uptake and transport", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis"], "type": "Family"}, "IPR004481": {"description": "Sodium/potassium/calcium exchanger", "go_ids": [], "go_terms": [], "name": "K/Na/Ca-exchanger", "pathway_ids": ["R-HSA-5619077", "R-DME-425561", "R-HSA-5619036", "R-HSA-425561", "R-HSA-2485179", "R-HSA-5619055", "R-RNO-425561", "R-MMU-425561"], "pathways": ["R-HSA-5619077:r:Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)", "R-DME-425561:r:Sodium/Calcium exchangers", "R-HSA-5619036:r:Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)", "R-HSA-425561:r:Sodium/Calcium exchangers", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-HSA-5619055:r:Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)", "R-RNO-425561:r:Sodium/Calcium exchangers", "R-MMU-425561:r:Sodium/Calcium exchangers"], "type": "Family"}, "IPR004482": {"description": "Mg 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"R-HSA-2408522", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Family"}, "IPR004494": {"description": "MauM/NapG ferredoxin-type protein", "go_ids": [], "go_terms": [], "name": "MauM_NapG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004495": {"description": "Methionyl-tRNA synthetase, beta subunit, C-terminal", "go_ids": ["GO:0000166", "GO:0004825", "GO:0005524", "GO:0006431"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004825:methionine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0006431:methionyl-tRNA aminoacylation:P"], "name": "Met-tRNA-synth_bsu_C", 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"PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729"], "pathways": ["PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)"], "type": "Family"}, "IPR004499": {"description": "Proline-tRNA ligase, class IIa, archaeal-type", "go_ids": ["GO:0004827", "GO:0005524", "GO:0005737", "GO:0006433"], "go_terms": ["GO:0004827:proline-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006433:prolyl-tRNA aminoacylation:P"], "name": "Pro-tRNA-ligase_IIa_arc-type", "pathway_ids": ["R-MMU-9856649", "R-HSA-9856649", "R-HSA-2408522", "R-HSA-6782315", "R-HSA-379716", "R-DME-9856649"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Family"}, "IPR004500": {"description": "Prolyl-tRNA synthetase, class IIa, bacterial-type", "go_ids": ["GO:0004827", "GO:0005524", "GO:0005737", "GO:0006433"], "go_terms": ["GO:0004827:proline-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006433:prolyl-tRNA aminoacylation:P"], "name": "Pro-tRNA-synth_IIa_bac-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004501": {"description": "Phosphotransferase system, EIIC component, type 3", "go_ids": ["GO:0008982", "GO:0009401", "GO:0016020"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_EIIC_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004502": {"description": "Thioredoxins/glutaredoxin", "go_ids": ["GO:0009055", "GO:0015035", "GO:0045454"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0015035:protein-disulfide reductase activity:F", "GO:0045454:cell redox homeostasis:P"], "name": "Thio_glut", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004503": {"description": "Serine-tRNA ligase type 2, archaea", "go_ids": ["GO:0000166", "GO:0004828", "GO:0005524", "GO:0005737", "GO:0006434"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004828:serine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006434:seryl-tRNA aminoacylation:P"], "name": "Ser-tRNA-ligase_2_arc", "pathway_ids": ["PWY-6281"], "pathways": ["PWY-6281:t:L-selenocysteine biosynthesis II (archaea and eukaryotes)"], "type": "Family"}, "IPR004504": {"description": "DNA repair protein RadA", "go_ids": ["GO:0003684", "GO:0005524", "GO:0006281"], "go_terms": ["GO:0003684:damaged DNA binding:F", "GO:0005524:ATP binding:F", "GO:0006281:DNA repair:P"], "name": "DNA_repair_RadA", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Family"}, "IPR004506": {"description": "tRNA-specific 2-thiouridylase MnmA-like", "go_ids": ["GO:0008033", "GO:0016740"], "go_terms": ["GO:0008033:tRNA processing:P", "GO:0016740:transferase activity:F"], "name": "MnmA-like", "pathway_ids": ["PWY-7892", "PWY-7887", "R-HSA-6787450"], "pathways": ["PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Family"}, "IPR004507": {"description": "Flavin prenyltransferase UbiX-like", "go_ids": [], "go_terms": [], "name": "UbiX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004508": {"description": "Thioredoxin-independent 5'-adenylylsulphate reductase", "go_ids": ["GO:0016671", "GO:0000103"], "go_terms": ["GO:0016671:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor:F", "GO:0000103:sulfate assimilation:P"], "name": "Thioredoxin-indep_APS_Rdtase", "pathway_ids": ["PWY-6932"], "pathways": ["PWY-6932:t:selenate reduction"], "type": "Family"}, "IPR004509": {"description": "Competence protein ComEA, helix-hairpin-helix domain", "go_ids": [], "go_terms": [], "name": "Competence_ComEA_HhH", "pathway_ids": ["R-HSA-9029569"], "pathways": ["R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "type": "Domain"}, "IPR004511": {"description": "Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase", "go_ids": ["GO:0004604"], "go_terms": ["GO:0004604:phosphoadenylyl-sulfate reductase (thioredoxin) activity:F"], "name": "PAPS/APS_Rdtase", "pathway_ids": ["R-MTU-936721"], "pathways": ["R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Family"}, "IPR004512": {"description": "Ribosomal RNA methyltransferase E, gammaproteobacteria", "go_ids": ["GO:0006364", "GO:0016436"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0016436:rRNA (uridine) methyltransferase activity:F"], "name": "rRNA_MeTrfase_gammaproteobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004513": {"description": "Cell division protein FtsX", "go_ids": ["GO:0016020", "GO:0051301"], "go_terms": ["GO:0016020:membrane:C", "GO:0051301:cell division:P"], "name": "FtsX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004514": {"description": "Glutamine-tRNA synthetase", "go_ids": ["GO:0000166", "GO:0004819", "GO:0005524", "GO:0005737", "GO:0006425"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004819:glutamine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006425:glutaminyl-tRNA aminoacylation:P"], "name": "Gln-tRNA-synth", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-RNO-9856649", "R-DME-9856649", "R-HSA-9856649", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Family"}, "IPR004515": {"description": "Phosphoheptose isomerase", "go_ids": ["GO:0008968"], "go_terms": ["GO:0008968:D-sedoheptulose 7-phosphate isomerase activity:F"], "name": "Phosphoheptose_Isoase", "pathway_ids": ["PWY-6478"], "pathways": ["PWY-6478:t:GDP-D-glycero-alpha-D-manno-heptose biosynthesis"], "type": "Family"}, "IPR004516": {"description": "Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "HisRS/HisZ", "pathway_ids": ["R-HSA-379716", "R-HSA-379726"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Family"}, "IPR004517": {"description": "ATP phosphoribosyltransferase regulatory subunit", "go_ids": ["GO:0000105", "GO:0005737"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0005737:cytoplasm:C"], "name": "HisZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004518": {"description": "NTP pyrophosphohydrolase MazG-like domain", "go_ids": [], "go_terms": [], "name": "MazG-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004519": {"description": "DNA-directed RNA polymerase, subunit E/RPC8", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "RNAP_E/RPC8", "pathway_ids": ["R-SCE-76066", "R-HSA-76071", "R-SPO-76066", "R-HSA-73980", "R-MMU-76061", "R-HSA-76066", "R-SPO-76061", "R-MMU-76071", "R-HSA-76061", "R-HSA-1834949", "R-MMU-76066", "R-HSA-73780", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR004520": {"description": "tRNA modification GTPase MnmE", "go_ids": ["GO:0003924", "GO:0005525", "GO:0006400"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005525:GTP binding:F", "GO:0006400:tRNA modification:P"], "name": "GTPase_MnmE", "pathway_ids": ["R-HSA-6787450"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Family"}, "IPR004521": {"description": "Uncharacterised domain CHP00451", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Uncharacterised_CHP00451", "pathway_ids": ["R-CEL-171319", "R-SPO-171319", "R-GGA-417076", "R-SCE-171319", "R-DRE-171319", "R-RNO-171319", "R-DDI-171319", "R-HSA-6790901", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-CEL-171319:r:Telomere Extension By Telomerase", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-GGA-417076:r:Assembly of telomerase and telomere extension", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DDI-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR004522": {"description": "Asparagine-tRNA ligase", "go_ids": ["GO:0000166", "GO:0004816", "GO:0005524", "GO:0006421"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004816:asparagine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0006421:asparaginyl-tRNA aminoacylation:P"], "name": "Asn-tRNA-ligase", "pathway_ids": ["R-HSA-379716", "R-HSA-379726"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Family"}, "IPR004523": {"description": "Aspartate-tRNA synthetase, type 2", "go_ids": ["GO:0000166", "GO:0004815", "GO:0005524", "GO:0005737", "GO:0006422"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004815:aspartate-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006422:aspartyl-tRNA aminoacylation:P"], "name": "Asp-tRNA_synthase_2", "pathway_ids": ["R-MMU-9856649", "R-HSA-9856649", "R-DDI-9856649", "R-HSA-2408522", "R-HSA-379716", "R-RNO-9856649"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Family"}, "IPR004524": {"description": "Aspartate-tRNA ligase, type 1", "go_ids": ["GO:0005524", "GO:0016874"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016874:ligase activity:F"], "name": "Asp-tRNA-ligase_1", "pathway_ids": ["R-HSA-379726"], "pathways": ["R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Family"}, "IPR004525": {"description": "Elongation factor P--(R)-beta-lysine ligase", "go_ids": ["GO:0004824", "GO:0005524", "GO:0005737", "GO:0006430"], "go_terms": ["GO:0004824:lysine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006430:lysyl-tRNA aminoacylation:P"], "name": "EpmA", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin 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"Family"}, "IPR004554": {"description": "Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type", "go_ids": ["GO:0005515", "GO:0004420", "GO:0008299"], "go_terms": ["GO:0005515:protein binding:F", "GO:0004420:hydroxymethylglutaryl-CoA reductase (NADPH) activity:F", "GO:0008299:isoprenoid biosynthetic process:P"], "name": "HMG_CoA_Rdtase_eu_arc", "pathway_ids": ["PWY-7524", "PWY-7391", "PWY-922", "PWY-8125", "PWY-6174", "R-SCE-9969896", "R-HSA-1989781", "R-DME-9969896", "R-RNO-9969896", "R-BTA-9969896", "R-HSA-9619665", "R-DDI-9969896", "R-MMU-9969896", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["PWY-7524:t:mevalonate pathway III (Thermoplasma)", "PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "PWY-8125:t:mevalonate pathway IV (archaea)", "PWY-6174:t:mevalonate pathway II (haloarchaea)", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9969896:r:Lanosterol biosynthesis", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR004555": {"description": "Glucose-6-phosphate dehydrogenase assembly protein OpcA", "go_ids": [], "go_terms": [], "name": "G6PDH_assembly_OpcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004556": {"description": "Methyltransferase HemK-like", "go_ids": ["GO:0008276"], "go_terms": ["GO:0008276:protein methyltransferase activity:F"], "name": "HemK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004557": {"description": "Eukaryotic/archaeal PrmC-related", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "PrmC-related", "pathway_ids": ["R-HSA-156581", "R-HSA-72764", "R-MMU-156581", "R-SCE-72764", "R-SCE-156581", "R-MMU-72764"], "pathways": ["R-HSA-156581:r:Methylation", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-MMU-156581:r:Methylation", "R-SCE-72764:r:Eukaryotic Translation Termination", "R-SCE-156581:r:Methylation", "R-MMU-72764:r:Eukaryotic Translation Termination"], "type": "Family"}, "IPR004558": {"description": "Oxygen-independent coproporphyrinogen III oxidase HemN", "go_ids": ["GO:0004109", "GO:0005737", "GO:0006779"], "go_terms": ["GO:0004109:coproporphyrinogen oxidase activity:F", "GO:0005737:cytoplasm:C", "GO:0006779:porphyrin-containing compound biosynthetic process:P"], "name": "Coprogen_oxidase_HemN", "pathway_ids": ["PWY-5531"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)"], "type": "Family"}, "IPR004559": {"description": "Heme chaperone HemW-like", "go_ids": ["GO:0051539", "GO:0004109", "GO:0005737", "GO:0006779"], "go_terms": ["GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0004109:coproporphyrinogen oxidase activity:F", "GO:0005737:cytoplasm:C", "GO:0006779:porphyrin-containing compound biosynthetic process:P"], "name": "HemW-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004560": {"description": "L-ribulose-5-phosphate 3-epimerase", "go_ids": ["GO:0005975", "GO:0016861"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016861:intramolecular oxidoreductase activity, interconverting aldoses and ketoses:F"], "name": "L-Ru-5P_3-Epase", "pathway_ids": ["PWY-6961"], "pathways": ["PWY-6961:t:L-ascorbate degradation II (bacterial, aerobic)"], "type": "Family"}, "IPR004561": {"description": "Isochorismate synthase", "go_ids": ["GO:0008909", "GO:0009058"], "go_terms": ["GO:0008909:isochorismate synthase activity:F", "GO:0009058:biosynthetic process:P"], "name": "IsoChor_synthase", "pathway_ids": ["PWY-8321", "PWY-6406", "PWY-5837", "PWY-5901"], "pathways": ["PWY-8321:t:salicylate biosynthesis II", "PWY-6406:t:salicylate biosynthesis I", "PWY-5837:t:2-carboxy-1,4-naphthoquinol biosynthesis", "PWY-5901:t:2,3-dihydroxybenzoate biosynthesis"], "type": "Family"}, "IPR004562": {"description": "Lipoyltransferase/lipoate-protein ligase", "go_ids": ["GO:0009249"], "go_terms": ["GO:0009249:protein lipoylation:P"], "name": "LipoylTrfase_LipoateP_Ligase", "pathway_ids": ["R-SPO-9857492", "R-SCE-9857492", "R-BTA-9857492", "R-PFA-9857492", "R-MMU-9857492", "R-HSA-9857492"], "pathways": ["R-SPO-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-BTA-9857492:r:Protein lipoylation", "R-PFA-9857492:r:Protein lipoylation", "R-MMU-9857492:r:Protein lipoylation", "R-HSA-9857492:r:Protein lipoylation"], "type": "Family"}, "IPR004563": {"description": "Apolipoprotein N-acyltransferase", "go_ids": ["GO:0016020", "GO:0042158", "GO:0016747"], "go_terms": ["GO:0016020:membrane:C", 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"name": "PanK", "pathway_ids": ["PWY-3961"], "pathways": ["PWY-3961:t:phosphopantothenate biosynthesis II"], "type": "Family"}, "IPR004567": {"description": "Type II pantothenate kinase", "go_ids": ["GO:0005524", "GO:0015937"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0015937:coenzyme A biosynthetic process:P"], "name": "Type_II_PanK", "pathway_ids": ["PWY-3961", "R-BTA-196783", "R-SCE-199220", "R-SPO-199220", "R-MMU-196783", "R-HSA-199220", "R-HSA-196783", "R-MMU-199220", "R-RNO-199220"], "pathways": ["PWY-3961:t:phosphopantothenate biosynthesis II", "R-BTA-196783:r:Coenzyme A biosynthesis", "R-SCE-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SPO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-196783:r:Coenzyme A biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-196783:r:Coenzyme A biosynthesis", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Family"}, "IPR004568": {"description": "Phosphopantetheine-protein transferase domain", "go_ids": ["GO:0000287", "GO:0006633", "GO:0008897"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0006633:fatty acid biosynthetic process:P", "GO:0008897:holo-[acyl-carrier-protein] synthase activity:F"], "name": "Ppantetheine-prot_Trfase_dom", "pathway_ids": ["PWY-6012", "PWY-6289"], "pathways": ["PWY-6012:t:acyl carrier protein metabolism", "PWY-6289:t:petrobactin biosynthesis"], "type": "Domain"}, "IPR004569": {"description": "Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ", "go_ids": ["GO:0005737", "GO:0008615", "GO:0033856"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008615:pyridoxine biosynthetic process:P", "GO:0033856:pyridoxine 5'-phosphate synthase activity:F"], "name": "PyrdxlP_synth_PdxJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004570": {"description": "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase", "go_ids": ["GO:0008444", "GO:0008654", 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"R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR004576": {"description": "Transcription-repair coupling factor", "go_ids": ["GO:0003684", "GO:0005524", "GO:0006281"], "go_terms": ["GO:0003684:damaged DNA binding:F", "GO:0005524:ATP binding:F", "GO:0006281:DNA repair:P"], "name": "Mfd", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Family"}, "IPR004577": {"description": "8-oxoguanine DNA-glycosylase", "go_ids": ["GO:0008534", "GO:0006284", "GO:0034039"], "go_terms": ["GO:0008534:oxidized purine nucleobase lesion DNA N-glycosylase activity:F", "GO:0006284:base-excision repair:P", "GO:0034039:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity:F"], "name": "Ogg1", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9656255", "R-SCE-110330", "R-HSA-110357", "R-MMU-5649702", "R-MMU-110330", "R-RNO-110331", "R-HSA-110328", "R-HSA-9656256", "R-RNO-110357", "R-SCE-110329", "R-HSA-5649702", "R-MMU-110331", "R-HSA-110331", "R-RNO-5649702", "R-HSA-9657050", "R-MMU-110329", "R-HSA-110329", "R-RNO-110330", "R-SCE-110331", "R-HSA-110330", "R-MMU-110357", "R-RNO-110329"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9656255:r:Defective OGG1 Substrate Binding", "R-SCE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9656256:r:Defective OGG1 Substrate Processing", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-SCE-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110331:r:Cleavage of the damaged purine", "R-HSA-110331:r:Cleavage of the damaged purine", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-9657050:r:Defective OGG1 Localization", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-SCE-110331:r:Cleavage of the damaged purine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-RNO-110329:r:Cleavage of the damaged pyrimidine"], "type": "Family"}, "IPR004579": {"description": "ERCC1/RAD10/SWI10 family", "go_ids": ["GO:0003684", "GO:0005634", "GO:0006281"], "go_terms": ["GO:0003684:damaged DNA binding:F", "GO:0005634:nucleus:C", "GO:0006281:DNA repair:P"], "name": "ERCC1/RAD10/SWI10", "pathway_ids": ["R-DDI-6782135", "R-DDI-5696395", "R-BTA-5685938", "R-MMU-6782135", "R-BTA-6782135", "R-HSA-6782135", "R-MMU-5685938", "R-HSA-6783310", "R-MMU-6783310", "R-MMU-5696395", "R-SPO-5696395", "R-SPO-5696400", "R-BTA-6783310", "R-HSA-5696395", "R-HSA-5696400", "R-BTA-5696395", "R-SPO-6782135", "R-BTA-5696400", "R-HSA-5685938", "R-MMU-5696400"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5696400:r:Dual Incision in GG-NER"], "type": "Family"}, "IPR004580": {"description": "DNA repair protein Rad18, fungi", "go_ids": ["GO:0061630", "GO:0006301", "GO:0006513", "GO:0003697"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0006301:DNA damage tolerance:P", "GO:0006513:protein monoubiquitination:P", "GO:0003697:single-stranded DNA binding:F"], "name": "Rad18_fungi", "pathway_ids": ["PWY-7511", "R-SPO-110314"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex"], "type": "Family"}, "IPR004582": {"description": "Checkpoint protein Rad17/Rad24", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "Checkpoint_prot_Rad17_Rad24", "pathway_ids": ["R-MMU-69473", "R-SPO-176187", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-MMU-5685938", "R-HSA-5693616", "R-HSA-69473", "R-SCE-176187", "R-MMU-176187", "R-MMU-6804756", "R-HSA-176187", "R-HSA-5685938", "R-MMU-5693607"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Family"}, "IPR004583": {"description": "DNA repair protein Rad4", "go_ids": ["GO:0003684", "GO:0005634", "GO:0006289"], "go_terms": ["GO:0003684:damaged DNA binding:F", "GO:0005634:nucleus:C", "GO:0006289:nucleotide-excision repair:P"], "name": "DNA_repair_Rad4", "pathway_ids": ["R-SCE-3108214", "R-MMU-5696395", "R-SPO-5696395", "R-SPO-3108214", "R-HSA-3108214", "R-HSA-5696395", "R-HSA-5696394", "R-SPO-5696394", "R-MMU-5696394", 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"R-SPO-3108214", "R-GGA-3108214", "R-HSA-3108214", "R-SPO-5685938", "R-MMU-5685939", "R-GGA-5685939", "R-MMU-3108214", "R-HSA-5685939", "R-HSA-5685938"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-GGA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Family"}, "IPR004586": {"description": "RecBCD enzyme subunit RecB", "go_ids": ["GO:0005524", "GO:0006281", "GO:0008854"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006281:DNA repair:P", "GO:0008854:exodeoxyribonuclease V activity:F"], "name": "RecB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004588": {"description": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type", "go_ids": ["GO:0016114", "GO:0046429"], "go_terms": ["GO:0016114:terpenoid biosynthetic process:P", "GO:0046429:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin):F"], "name": "IspG_bac-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004589": {"description": "DNA helicase, ATP-dependent, RecQ type", "go_ids": ["GO:0006310", "GO:0004386"], "go_terms": ["GO:0006310:DNA recombination:P", "GO:0004386:helicase activity:F"], "name": "DNA_helicase_ATP-dep_RecQ", "pathway_ids": ["R-HSA-3108214", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-174414", 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Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR004601": {"description": "UV-endonuclease UvdE", "go_ids": ["GO:0004519", "GO:0006289", "GO:0009411"], "go_terms": ["GO:0004519:endonuclease activity:F", "GO:0006289:nucleotide-excision repair:P", "GO:0009411:response to UV:P"], "name": "UvdE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004602": {"description": "UvrABC system subunit A", "go_ids": ["GO:0006289", "GO:0009380", "GO:0003677", "GO:0016887"], "go_terms": ["GO:0006289:nucleotide-excision repair:P", "GO:0009380:excinuclease repair complex:C", "GO:0003677:DNA binding:F", "GO:0016887:ATP hydrolysis activity:F"], "name": "UvrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004603": {"description": "DNA mismatch endonuclease VSR", "go_ids": ["GO:0004519", "GO:0006298"], "go_terms": ["GO:0004519:endonuclease activity:F", "GO:0006298:mismatch repair:P"], "name": "DNA_mismatch_endonuc_vsr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004604": {"description": "DNA recombination/repair protein RecN", "go_ids": ["GO:0005524", "GO:0006281", "GO:0006310"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P"], "name": "DNA_recomb/repair_RecN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004605": {"description": "Holliday junction branch migration complex subunit RuvB", "go_ids": ["GO:0003677", "GO:0005524", "GO:0006281", "GO:0006310", "GO:0009378"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0009378:four-way junction helicase activity:F"], "name": "DNA_helicase_Holl-junc_RuvB", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Family"}, "IPR004606": {"description": "Molybdenum-pterin binding domain", "go_ids": ["GO:0015689"], "go_terms": ["GO:0015689:molybdate ion transport:P"], "name": "Mop_domain", "pathway_ids": ["PWY-8171"], "pathways": ["PWY-8171:t:molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR004607": {"description": "Phosphoribosylglycinamide formyltransferase", "go_ids": ["GO:0004644", "GO:0006189"], "go_terms": ["GO:0004644:phosphoribosylglycinamide formyltransferase activity:F", "GO:0006189:'de novo' IMP biosynthetic process:P"], "name": "GART", "pathway_ids": ["PWY-6613", "PWY-6121", "R-BTA-73817", "R-MMU-73817", "R-HSA-73817", "R-DME-73817", "R-GGA-419140"], "pathways": ["PWY-6613:t:tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Family"}, "IPR004608": {"description": "Methylmalonyl-CoA mutase, small subunit", "go_ids": ["GO:0004494"], "go_terms": ["GO:0004494:methylmalonyl-CoA mutase activity:F"], "name": "MMCoA_mutase_b", "pathway_ids": ["PWY-5743", "PWY-8086", "PWY-5789", "PWY-7854", "PWY-7384", "PWY-6728"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-6728:t:methylaspartate cycle"], "type": "Family"}, "IPR004609": {"description": "ATP-dependent DNA helicase RecG", "go_ids": ["GO:0003678", "GO:0006281", "GO:0006310"], "go_terms": ["GO:0003678:DNA helicase activity:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P"], "name": "ATP-dep_DNA_helicase_RecG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004610": {"description": "Bacterial RecJ exonuclease", "go_ids": ["GO:0006281", "GO:0006310", "GO:0008409"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0008409:5'-3' exonuclease activity:F"], "name": "RecJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004611": {"description": "DNA primase-related protein", "go_ids": [], "go_terms": [], "name": "DNA_primase-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004612": {"description": "Holliday junction resolvase RecU", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "Resolv_RecU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004613": {"description": "Ribonuclease J", "go_ids": ["GO:0003723", "GO:0046872"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0046872:metal ion binding:F"], "name": "RNase_J", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004614": {"description": "Phosphate acetyltransferase", "go_ids": ["GO:0016407"], "go_terms": ["GO:0016407:acetyltransferase activity:F"], "name": "P_AcTrfase", "pathway_ids": ["PWY-8086", "PWY-1281", "PWY-8377", "PWY-5497", "PWY-5485", "PWY-6637", "PWY-5482"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1281:t:sulfoacetaldehyde degradation I", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-5485:t:pyruvate fermentation to acetate IV", "PWY-6637:t:sulfolactate degradation II", "PWY-5482:t:pyruvate fermentation to acetate II"], "type": "Domain"}, "IPR004615": {"description": "DNA polymerase III, psi subunit", "go_ids": ["GO:0003887", "GO:0006260", "GO:0008408"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P", "GO:0008408:3'-5' exonuclease activity:F"], "name": "DNA_pol_III_psi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004616": {"description": "Leucyl/phenylalanyl-tRNA-protein transferase", "go_ids": ["GO:0008914", "GO:0030163"], "go_terms": ["GO:0008914:leucyl-tRNA--protein transferase activity:F", "GO:0030163:protein catabolic process:P"], "name": "Leu/Phe-tRNA_Trfase", "pathway_ids": ["PWY-7801"], "pathways": ["PWY-7801:t:N-end rule pathway I (prokaryotic)"], "type": "Family"}, "IPR004617": {"description": "Bis(5'-nucleosyl)-tetraphosphatase, symmetrical", "go_ids": ["GO:0008803"], "go_terms": ["GO:0008803:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity:F"], "name": "ApaH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004618": {"description": "Aspartate--ammonia ligase", "go_ids": ["GO:0004071", "GO:0005737", "GO:0070981"], "go_terms": ["GO:0004071:aspartate-ammonia ligase activity:F", "GO:0005737:cytoplasm:C", "GO:0070981:L-asparagine biosynthetic process:P"], "name": "AsnA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004619": {"description": "Type III pantothenate kinase", "go_ids": ["GO:0004594"], "go_terms": ["GO:0004594:pantothenate kinase activity:F"], "name": "Type_III_PanK", "pathway_ids": ["PWY-3961"], "pathways": ["PWY-3961:t:phosphopantothenate biosynthesis II"], "type": "Family"}, "IPR004620": {"description": "5,10-methylenetetrahydrofolate reductase", "go_ids": ["GO:0004489", "GO:0005829"], "go_terms": ["GO:0004489:methylenetetrahydrofolate reductase [NAD(P)H] activity:F", "GO:0005829:cytosol:C"], "name": "MTHF_reductase_bac", "pathway_ids": ["PWY-3841", "PWY-2201"], "pathways": ["PWY-3841:t:folate transformations II (plants)", "PWY-2201:t:folate transformations I"], "type": "Family"}, "IPR004621": {"description": "Methylenetetrahydrofolate reductase, catalytic domain, eukaryotes", "go_ids": ["GO:0004489", "GO:0006555"], "go_terms": ["GO:0004489:methylenetetrahydrofolate reductase [NAD(P)H] activity:F", "GO:0006555:L-methionine metabolic process:P"], "name": "Fadh2_euk", "pathway_ids": ["R-SCE-196757", "R-SPO-196757", "R-HSA-196757", "R-MMU-196757", "R-CEL-196757"], "pathways": ["R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Domain"}, "IPR004622": {"description": "DNA polymerase III, delta prime subunit", "go_ids": ["GO:0003887", "GO:0006260", "GO:0008408"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P", "GO:0008408:3'-5' exonuclease activity:F"], "name": "DNA_pol_HolB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004623": {"description": "Potassium-transporting ATPase A chain", "go_ids": ["GO:0006813", "GO:0008556"], "go_terms": ["GO:0006813:potassium ion transport:P", "GO:0008556:P-type potassium transmembrane transporter activity:F"], "name": "KdpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004624": {"description": "Protein YjdM", "go_ids": [], "go_terms": [], "name": "YjdM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004625": {"description": "Pyridoxine kinase", "go_ids": ["GO:0009443", "GO:0008478"], "go_terms": ["GO:0009443:pyridoxal 5'-phosphate salvage:P", "GO:0008478:pyridoxal kinase activity:F"], "name": "PyrdxlKinase", "pathway_ids": ["PWY-7204", "PWY-7282", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-BTA-964975", "R-RNO-964975", "R-HSA-964975", "R-CEL-6798695", "R-CEL-964975", "R-SCE-6798695", "R-MMU-6798695", "R-MMU-964975", "R-BTA-6798695", "R-DDI-964975", "R-SCE-964975", "R-RNO-6798695", "R-SPO-964975"], "pathways": ["PWY-7204:t:pyridoxal 5'-phosphate salvage II (plants)", "PWY-7282:t:4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-SCE-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-6798695:r:Neutrophil degranulation", "R-SPO-964975:r:Vitamin B6 activation to pyridoxal phosphate"], "type": "Family"}, "IPR004626": {"description": "RarD protein", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "RarD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004627": {"description": "L-threonine 3-dehydrogenase", "go_ids": ["GO:0006567", "GO:0008270", "GO:0008743"], "go_terms": ["GO:0006567:L-threonine catabolic process:P", "GO:0008270:zinc ion binding:F", "GO:0008743:L-threonine 3-dehydrogenase activity:F"], "name": "L-Threonine_3-DHase", "pathway_ids": ["PWY-7378"], "pathways": ["PWY-7378:t:aminopropanol phosphate biosynthesis II"], "type": "Family"}, "IPR004628": {"description": "Mannonate dehydratase", "go_ids": ["GO:0006064", "GO:0008927"], "go_terms": ["GO:0006064:glucuronate catabolic process:P", "GO:0008927:mannonate dehydratase activity:F"], "name": "Man_deHydtase", "pathway_ids": ["PWY-7242"], "pathways": ["PWY-7242:t:D-fructuronate degradation"], "type": "Family"}, "IPR004629": {"description": "Glycosyl transferase WecG/TagA/CpsF", "go_ids": ["GO:0016740", "GO:0009058"], "go_terms": ["GO:0016740:transferase activity:F", "GO:0009058:biosynthetic process:P"], "name": "WecG_TagA_CpsF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004630": {"description": "UPF0324 inner membrane protein YeiH-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "UPF0324_YeiH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004631": {"description": "4-aminobutyrate aminotransferase, eukaryotic", "go_ids": ["GO:0034386"], "go_terms": ["GO:0034386:4-aminobutyrate:2-oxoglutarate transaminase activity:F"], "name": "4NH2But_aminotransferase_euk", "pathway_ids": ["PWY-6535", "PWY-6537", "PWY-5022", "PWY-8346", "PWY-6536", "R-RNO-916853", "R-SSC-916853", "R-CEL-916853", "R-DDI-916853", "R-SPO-916853", "R-HSA-916853", "R-SCE-916853", "R-MMU-916853"], "pathways": ["PWY-6535:t:4-aminobutanoate degradation I", "PWY-6537:t:4-aminobutanoate degradation II", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-8346:t:GABA shunt II", "PWY-6536:t:4-aminobutanoate degradation III", "R-RNO-916853:r:Degradation of GABA", "R-SSC-916853:r:Degradation of GABA", "R-CEL-916853:r:Degradation of GABA", "R-DDI-916853:r:Degradation of GABA", "R-SPO-916853:r:Degradation of GABA", "R-HSA-916853:r:Degradation of GABA", "R-SCE-916853:r:Degradation of GABA", "R-MMU-916853:r:Degradation of GABA"], "type": "Family"}, "IPR004632": {"description": "4-aminobutyrate aminotransferase, bacterial", "go_ids": ["GO:0034386"], "go_terms": ["GO:0034386:4-aminobutyrate:2-oxoglutarate transaminase activity:F"], "name": "4NH2But_aminotransferase_bac", "pathway_ids": ["PWY-6535", "PWY-6537", "PWY-5022", "PWY-8346", "PWY-6536"], "pathways": ["PWY-6535:t:4-aminobutanoate degradation I", "PWY-6537:t:4-aminobutanoate degradation II", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-8346:t:GABA shunt II", "PWY-6536:t:4-aminobutanoate degradation III"], "type": "Family"}, "IPR004633": {"description": "Na/Pi-cotransporter II-related/YqeW-like protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "NaPi_cotrn-rel/YqeW-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004634": {"description": "Peptidase S49, protease IV", "go_ids": ["GO:0008233", "GO:0016020", "GO:0051604"], "go_terms": ["GO:0008233:peptidase activity:F", "GO:0016020:membrane:C", "GO:0051604:protein maturation:P"], "name": "Pept_S49_pIV", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR004635": {"description": "Peptidase S49, SppA", "go_ids": ["GO:0006508", "GO:0008233"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008233:peptidase activity:F"], "name": "Pept_S49_SppA", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR004636": {"description": "Acetylornithine/Succinylornithine transaminase family", "go_ids": ["GO:0006525", "GO:0008483"], "go_terms": ["GO:0006525:arginine metabolic process:P", "GO:0008483:transaminase activity:F"], "name": "AcOrn/SuccOrn_fam", "pathway_ids": ["PWY-5154"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Family"}, "IPR004637": {"description": "2,4-diaminobutyrate 4-transaminase", "go_ids": ["GO:0008483", "GO:0009058"], "go_terms": ["GO:0008483:transaminase activity:F", "GO:0009058:biosynthetic process:P"], "name": "Dat", "pathway_ids": ["PWY-6562", "PWY-761", "PWY-6409", "PWY-7988", "PWY-7855"], "pathways": ["PWY-6562:t:norspermidine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7988:t:baumannoferrin 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"GO:0044571:[2Fe-2S] cluster assembly:P", "GO:0001671:ATPase activator activity:F"], "name": "HscB", "pathway_ids": ["R-SPO-9865881", "R-HSA-1362409", "R-HSA-9865881", "R-SCE-1362409", "R-HSA-1268020", "R-MMU-6799198", "R-HSA-6799198", "R-MMU-1362409", "R-MMU-1268020", "R-SCE-1268020", "R-SCE-9865881", "R-SPO-1268020", "R-SPO-1362409", "R-MMU-9865881"], "pathways": ["R-SPO-9865881:r:Complex III assembly", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9865881:r:Complex III assembly", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-1268020:r:Mitochondrial protein import", "R-SCE-1268020:r:Mitochondrial protein import", "R-SCE-9865881:r:Complex III assembly", "R-SPO-1268020:r:Mitochondrial protein import", "R-SPO-1362409:r:Mitochondrial iron-sulfur 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{"description": "Iron-sulphur-dependent L-serine dehydratase single chain form", "go_ids": ["GO:0003941", "GO:0006094"], "go_terms": ["GO:0003941:L-serine ammonia-lyase activity:F", "GO:0006094:gluconeogenesis:P"], "name": "Fe-S_L-Ser_mono", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004645": {"description": "DNA-binding protein Tfx, archaea", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Tfx_DNA-bd_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004646": {"description": "Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "Fe-S_hydro-lyase_TtdA-typ_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004647": {"description": "Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain", "go_ids": ["GO:0016836"], "go_terms": ["GO:0016836:hydro-lyase activity:F"], "name": "Fe-S_hydro-lyase_TtdB-typ_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004648": {"description": "Tetrapeptide transporter, OPT1/isp4", "go_ids": ["GO:0055085"], "go_terms": ["GO:0055085:transmembrane transport:P"], "name": "Oligpept_transpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004649": {"description": "Ribonuclease H2, subunit A", "go_ids": ["GO:0004523", "GO:0016070"], "go_terms": ["GO:0004523:RNA-DNA hybrid ribonuclease activity:F", "GO:0016070:RNA metabolic process:P"], "name": "RNase_H2_suA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004650": {"description": "HisA/HisF-like protein, archaeal", "go_ids": [], "go_terms": [], "name": "HisA/F-archaeal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004651": {"description": "Histidine biosynthesis, HisF", "go_ids": ["GO:0000105", "GO:0000107"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0000107:imidazoleglycerol-phosphate synthase activity:F"], "name": "HisF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004652": {"description": "tRNA-dihydrouridine synthase DusB-like", "go_ids": ["GO:0008033", "GO:0016491", "GO:0050660"], "go_terms": ["GO:0008033:tRNA processing:P", "GO:0016491:oxidoreductase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "DusB-like", "pathway_ids": ["PWY-6309", "PWY-8382", "PWY-7655", "PWY-5292", "PWY-7096", "PWY-7300", "PWY-8374", "PWY-5956", "PWY-8103", "PWY-6302", "PWY-6996", "PWY-7881", "PWY-6824", "PWY-7154", "PWY-5367", "PWY-8152", "PWY-5984", "PWY-5393", "PWY-5972", "PWY-6944", "PWY-7770", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-6332", "PWY-7846", "PWY-6088", "PWY-7155", "PWY-8044", "PWY-6786", "PWY-7653", "PWY-2541", "PWY-5818", "PWY-7826"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-7096:t:triclosan resistance", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-6996:t:daidzin and daidzein degradation", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-6824:t:justicidin B biosynthesis", "PWY-7154:t:ergosterol biosynthesis II", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-5984:t:rifamycin B biosynthesis", "PWY-5393:t:raspberry ketone biosynthesis", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7770:t:indolmycin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-6332:t:coumestrol biosynthesis", "PWY-7846:t:heme degradation V", "PWY-6088:t:3-chlorobenzoate degradation I (via chlorocatechol)", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-7653:t:griseofulvin biosynthesis", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWY-5818:t:validamycin biosynthesis", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis"], "type": "Family"}, "IPR004653": {"description": "tRNA-dihydrouridine(20/20a) synthase", "go_ids": ["GO:0002943", "GO:0017150"], "go_terms": ["GO:0002943:tRNA dihydrouridine synthesis:P", "GO:0017150:tRNA dihydrouridine synthase activity:F"], "name": "DusA", "pathway_ids": ["PWY-6309", "PWY-8382", "PWY-7655", "PWY-5292", "PWY-7096", "PWY-7300", "PWY-8374", "PWY-5956", "PWY-8103", "PWY-6302", "PWY-6996", "PWY-7881", "PWY-6824", "PWY-7154", "PWY-5367", "PWY-8152", "PWY-5984", "PWY-5393", "PWY-5972", "PWY-6944", "PWY-7770", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-6332", "PWY-7846", "PWY-6088", "PWY-7155", "PWY-8044", "PWY-6786", "PWY-7653", "PWY-2541", "PWY-5818", "PWY-7826"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-7096:t:triclosan resistance", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-6996:t:daidzin and daidzein degradation", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-6824:t:justicidin B biosynthesis", "PWY-7154:t:ergosterol biosynthesis II", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-5984:t:rifamycin B biosynthesis", "PWY-5393:t:raspberry ketone biosynthesis", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7770:t:indolmycin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-6332:t:coumestrol biosynthesis", "PWY-7846:t:heme degradation V", "PWY-6088:t:3-chlorobenzoate degradation I (via chlorocatechol)", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-7653:t:griseofulvin biosynthesis", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWY-5818:t:validamycin biosynthesis", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis"], "type": "Family"}, "IPR004654": {"description": "Glucokinase ROK", "go_ids": ["GO:0004340", "GO:0005737", "GO:0006096", "GO:0051156"], "go_terms": ["GO:0004340:glucokinase activity:F", "GO:0005737:cytoplasm:C", "GO:0006096:glycolytic process:P", "GO:0051156:glucose 6-phosphate metabolic process:P"], "name": "ROK_glcA", "pathway_ids": ["PWY-5514", "PWY-5661", "PWY-5941", "PWY-7238", "PWY-621", "PWY-2722", "PWY-7385", "PWY-2723"], "pathways": ["PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II", "PWY-5661:t:GDP-alpha-D-glucose biosynthesis", "PWY-5941:t:glycogen degradation II", "PWY-7238:t:sucrose biosynthesis II", "PWY-621:t:sucrose degradation III (sucrose invertase)", "PWY-2722:t:trehalose degradation IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-2723:t:trehalose degradation V"], "type": "Family"}, "IPR004655": {"description": "Beta-ketoacyl-[acyl-carrier-protein] synthase III", "go_ids": ["GO:0004315", "GO:0006633"], "go_terms": ["GO:0004315:3-oxoacyl-[acyl-carrier-protein] synthase activity:F", "GO:0006633:fatty acid biosynthetic process:P"], "name": "FabH", "pathway_ids": ["PWY-4381"], "pathways": ["PWY-4381:t:fatty acid biosynthesis initiation (type II)"], "type": "Family"}, "IPR004656": {"description": "Hydroxymethylglutaryl-CoA synthase", "go_ids": ["GO:0004421"], "go_terms": ["GO:0004421:hydroxymethylglutaryl-CoA synthase activity:F"], "name": "HMG_CoA_Synthase", "pathway_ids": ["PWY-7524", "PWY-7391", "PWY-922", "PWY-8125", "PWY-6174", "PWY-7571"], "pathways": ["PWY-7524:t:mevalonate pathway III (Thermoplasma)", "PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "PWY-8125:t:mevalonate pathway IV (archaea)", "PWY-6174:t:mevalonate pathway II (haloarchaea)", "PWY-7571:t:ferrichrome A biosynthesis"], "type": "Family"}, "IPR004658": {"description": "Outer membrane lipoprotein Slp", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "OMP_Slp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004659": {"description": "Ribonuclease E/G", "go_ids": ["GO:0004540", "GO:0006396", "GO:0003723"], "go_terms": ["GO:0004540:RNA nuclease activity:F", "GO:0006396:RNA processing:P", "GO:0003723:RNA binding:F"], "name": "RNase_E/G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004660": {"description": "Pyruvate dehydrogenase E1 component", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "PDH_E1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004661": {"description": "L-ribulose-5-phosphate 4-epimerase", "go_ids": ["GO:0008270", "GO:0008742", "GO:0019572"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0008742:L-ribulose-phosphate 4-epimerase activity:F", "GO:0019572:L-arabinose catabolic process:P"], "name": "AraD", "pathway_ids": ["PWY-6961"], "pathways": ["PWY-6961:t:L-ascorbate degradation II (bacterial, aerobic)"], "type": "Family"}, "IPR004662": {"description": "Acetylglutamate kinase family", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "AcgluKinase_fam", "pathway_ids": ["PWY-5154", "R-DDI-70635", "R-SCE-70635", "R-SPO-70635"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-DDI-70635:r:Urea cycle", "R-SCE-70635:r:Urea cycle", "R-SPO-70635:r:Urea cycle"], "type": "Family"}, "IPR004663": {"description": "Lon protease, archaeal", "go_ids": ["GO:0004176", "GO:0005524", "GO:0030163"], "go_terms": ["GO:0004176:ATP-dependent peptidase activity:F", "GO:0005524:ATP binding:F", "GO:0030163:protein catabolic process:P"], "name": "Lon_arc", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR004665": {"description": "Transcription termination factor Rho", "go_ids": ["GO:0005524", "GO:0006353", "GO:0008186", "GO:0003723"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006353:DNA-templated transcription termination:P", "GO:0008186:ATP-dependent activity, acting on RNA:F", "GO:0003723:RNA binding:F"], "name": "Term_rho", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] 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"PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline 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"go_terms": ["GO:0006814:sodium ion transport:P", "GO:0006885:regulation of pH:P", "GO:0016020:membrane:C"], "name": "NhaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004671": {"description": "Na+/H+ antiporter NhaB", "go_ids": ["GO:0006814", "GO:0015385", "GO:0016020"], "go_terms": ["GO:0006814:sodium ion transport:P", "GO:0015385:sodium:proton antiporter activity:F", "GO:0016020:membrane:C"], "name": "Na+/H+_antiporter_NhaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004672": {"description": "Na(+)/H(+) antiporter NhaD", "go_ids": ["GO:0015297", "GO:0006814"], "go_terms": ["GO:0015297:antiporter activity:F", "GO:0006814:sodium ion transport:P"], "name": "Na(+)/H(+)_antiporter_NhaD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004673": {"description": "L-rhamnose-proton symport, RhaT", "go_ids": ["GO:0008645", "GO:0015153", "GO:0016020"], "go_terms": ["GO:0008645:hexose transmembrane transport:P", "GO:0015153:rhamnose transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "L-rhamnose-proton_sym_RhaT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004674": {"description": "Alkylhydroperoxidase AhpD", "go_ids": ["GO:0006979", "GO:0051920"], "go_terms": ["GO:0006979:response to oxidative stress:P", "GO:0051920:peroxiredoxin activity:F"], "name": "AhpD", "pathway_ids": ["R-HSA-1222541"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis"], "type": "Family"}, "IPR004675": {"description": "Alkylhydroperoxidase AhpD core", "go_ids": [], "go_terms": [], "name": "AhpD_core", "pathway_ids": ["R-HSA-1222541"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis"], "type": "Domain"}, "IPR004676": {"description": "Cadmium resistance transporter", "go_ids": [], "go_terms": [], "name": "Cd-R_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004677": {"description": "Cytochrome c oxidase cbb3-type, subunit I", "go_ids": ["GO:0004129"], "go_terms": ["GO:0004129:cytochrome-c 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"pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004680": {"description": "Citrate transporter-like domain", "go_ids": ["GO:0016020", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "Cit_transptr-like_dom", "pathway_ids": ["R-HSA-5662702", "R-MMU-5662702"], "pathways": ["R-HSA-5662702:r:Melanin biosynthesis", "R-MMU-5662702:r:Melanin biosynthesis"], "type": "Domain"}, "IPR004681": {"description": "TRAP transporter large membrane protein DctM", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TRAP_DctM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004682": {"description": "TRAP transporter solute receptor, DctP family", "go_ids": ["GO:0030288", "GO:0055085"], "go_terms": ["GO:0030288:outer membrane-bounded periplasmic space:C", "GO:0055085:transmembrane transport:P"], "name": "TRAP_DctP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004683": {"description": "Uncharacterized protein YlqH", "go_ids": [], "go_terms": [], "name": "YlqH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004684": {"description": "2-keto-3-deoxygluconate permease", "go_ids": ["GO:0008643", "GO:0015649", "GO:0016020", "GO:0046411"], "go_terms": ["GO:0008643:carbohydrate transport:P", "GO:0015649:2-keto-3-deoxygluconate:proton symporter activity:F", "GO:0016020:membrane:C", "GO:0046411:2-keto-3-deoxygluconate transmembrane transport:P"], "name": "2keto-3dGluconate_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004685": {"description": "Branched-chain amino acid transport system II carrier protein", "go_ids": ["GO:0015658", "GO:0015803", "GO:0016020"], "go_terms": ["GO:0015658:branched-chain amino acid transmembrane transporter activity:F", "GO:0015803:branched-chain amino acid transport:P", "GO:0016020:membrane:C"], "name": "Brnchd-chn_aa_trnsp_Livcs", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004686": {"description": "Tricarboxylate/iron carrier", "go_ids": ["GO:0016020", "GO:0055085", "GO:0006811", "GO:0015075"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0006811:monoatomic ion transport:P", "GO:0015075:monoatomic ion transmembrane transporter activity:F"], "name": "Mtc", "pathway_ids": ["R-BTA-6799198", "R-HSA-6799198"], "pathways": ["R-BTA-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR004687": {"description": "Lysosomal-associated transmembrane protein 4/5", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "LAPTM4/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004688": {"description": "Transition metal uptake transporter nickel/cobalt", "go_ids": ["GO:0005886", "GO:0035444"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0035444:nickel cation transmembrane transport:P"], "name": "Ni/Co_transpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004690": {"description": "Malonate transporter MadL subunit", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Maln_transptMadL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004691": {"description": "Malonate/sodium symporter MadM subunit", "go_ids": ["GO:0044668"], "go_terms": ["GO:0044668:sodium:malonate symporter activity:F"], "name": "Mal/Na_symporter_MadM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004692": {"description": "Preprotein translocase SecG subunit", "go_ids": ["GO:0009306", "GO:0015450", "GO:0016020"], "go_terms": ["GO:0009306:protein secretion:P", "GO:0015450:protein-transporting ATPase activity:F", "GO:0016020:membrane:C"], "name": "SecG", "pathway_ids": ["R-HSA-9760173", "R-HSA-1222387"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Family"}, "IPR004693": {"description": "Silicon transporter", "go_ids": ["GO:0015708"], "go_terms": ["GO:0015708:silicic acid import across plasma membrane:P"], "name": "Silicon_transpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004694": {"description": "Hydroxy amino acid transporter", "go_ids": ["GO:0006865", "GO:0015171", "GO:0016020"], "go_terms": ["GO:0006865:amino acid transport:P", "GO:0015171:amino acid transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "Hydroxy_aa_transpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004695": {"description": "Transporter protein SLAC1/Mae1/ Ssu1/TehA", "go_ids": ["GO:0016020", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "SLAC1/Mae1/Ssu1/TehA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004696": {"description": "Triose phosphate/phosphoenolpyruvate translocator", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "Tpt_PEP_transl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004697": {"description": "p-Aminobenzoyl-glutamate transport protein AbgT", "go_ids": ["GO:1902604", "GO:0015558"], "go_terms": ["GO:1902604:p-aminobenzoyl-glutamate transmembrane transport:P", "GO:0015558:secondary active p-aminobenzoyl-glutamate transmembrane transporter activity:F"], "name": "AbgT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004698": {"description": "Zinc/iron permease, fungal/plant", "go_ids": ["GO:0005385", "GO:0016020", "GO:0071577"], "go_terms": ["GO:0005385:zinc ion transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0071577:zinc ion transmembrane transport:P"], "name": "Zn/Fe_permease_fun/pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004699": {"description": "Phosphotransferase system, enzyme II sorbitol-specific factor", "go_ids": ["GO:0009401", "GO:0016020"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_IID_sorb", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004700": {"description": "Phosphotransferase system, mannose/fructose/sorbose family, IIC subunit", "go_ids": ["GO:0009401", "GO:0016020"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_IIC_man", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004701": {"description": "Phosphotransferase system, mannose-type IIA component", "go_ids": ["GO:0009401", "GO:0016020"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_EIIA_man-typ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004702": {"description": "Phosphotransferease, sorbitol phosphotransferase enzyme II", "go_ids": ["GO:0008982", "GO:0009401", "GO:0016020"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_sorb_EIIBC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004703": {"description": "Phosphotransferase system, sugar-specific permease component", "go_ids": ["GO:0009401", "GO:0016020"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_sugar-sp_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004704": {"description": "Phosphotransferase system, mannose/fructose/sorbose family IID component", "go_ids": ["GO:0009401", "GO:0016020"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_IID_man", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004705": {"description": "Cation/H+ 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"GO:0006531"], "go_terms": ["GO:0008797:aspartate ammonia-lyase activity:F", "GO:0006531:aspartate metabolic process:P"], "name": "ApsA", "pathway_ids": ["PWY-8294", "PWY-8419", "PWY-8291"], "pathways": ["PWY-8294:t:L-aspartate degradation III (anaerobic)", "PWY-8419:t:L-canavanine degradation II", "PWY-8291:t:L-aspartate degradation II (aerobic)"], "type": "Family"}, "IPR004709": {"description": "Na+/H+ exchanger", "go_ids": ["GO:0006814", "GO:0006885", "GO:0015385", "GO:0016020", "GO:0055085"], "go_terms": ["GO:0006814:sodium ion transport:P", "GO:0006885:regulation of pH:P", "GO:0015385:sodium:proton antiporter activity:F", "GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "NaH_exchanger", "pathway_ids": ["R-SPO-425986", "R-CEL-425986", "R-HSA-425986", "R-SCE-425986", "R-BTA-2160916", "R-MMU-425986", "R-RNO-425986", "R-BTA-425986", "R-HSA-5619092", "R-MMU-2160916", "R-DDI-425986", "R-HSA-2160916", "R-RNO-2160916", "R-HSA-5619052"], "pathways": ["R-SPO-425986:r:Sodium/Proton exchangers", "R-CEL-425986:r:Sodium/Proton exchangers", "R-HSA-425986:r:Sodium/Proton exchangers", "R-SCE-425986:r:Sodium/Proton exchangers", "R-BTA-2160916:r:Hyaluronan degradation", "R-MMU-425986:r:Sodium/Proton exchangers", "R-RNO-425986:r:Sodium/Proton exchangers", "R-BTA-425986:r:Sodium/Proton exchangers", "R-HSA-5619092:r:Defective SLC9A6 causes X-linked, syndromic mental retardation, Christianson type (MRXSCH)", "R-MMU-2160916:r:Hyaluronan degradation", "R-DDI-425986:r:Sodium/Proton exchangers", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-HSA-5619052:r:Defective SLC9A9 causes autism 16 (AUTS16)"], "type": "Family"}, "IPR004710": {"description": "Bile acid:sodium symporter", "go_ids": [], "go_terms": [], "name": "Bilac:Na_transpt", "pathway_ids": ["R-HSA-159418", "R-RNO-9958517", "R-MMU-9958517", "R-RNO-159418", "R-MMU-159418", "R-HSA-9958517"], "pathways": ["R-HSA-159418:r:Recycling of bile acids and salts", "R-RNO-9958517:r:SLC-mediated bile acid transport", "R-MMU-9958517:r:SLC-mediated bile acid transport", "R-RNO-159418:r:Recycling of bile acids and salts", "R-MMU-159418:r:Recycling of bile acids and salts", "R-HSA-9958517:r:SLC-mediated bile acid transport"], "type": "Family"}, "IPR004711": {"description": "Benzoate transporter", "go_ids": ["GO:0016020", "GO:0042919", "GO:0042925"], "go_terms": ["GO:0016020:membrane:C", "GO:0042919:benzoate transport:P", "GO:0042925:benzoate transmembrane transporter activity:F"], "name": "Benzoate_Transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004712": {"description": "Na+/H+ antiporter, fungi", "go_ids": ["GO:0042391", "GO:0036376", "GO:0120029", "GO:0015385", "GO:0005886"], "go_terms": ["GO:0042391:regulation of membrane potential:P", "GO:0036376:sodium ion export across plasma membrane:P", "GO:0120029:proton export across plasma membrane:P", "GO:0015385:sodium:proton antiporter activity:F", "GO:0005886:plasma membrane:C"], "name": "Na+/H+_antiporter_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004713": {"description": "Calcium/proton exchanger", "go_ids": ["GO:0006812", "GO:0008324", "GO:0016020"], "go_terms": ["GO:0006812:monoatomic cation transport:P", "GO:0008324:monoatomic cation transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "CaH_exchang", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004714": {"description": "Cytochrome oxidase maturation protein cbb3-type", "go_ids": [], "go_terms": [], "name": "Cyt_oxidase_maturation_cbb3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004715": {"description": "Phosphotransferase system, IIA component fructose subfamily", "go_ids": ["GO:0008982", "GO:0009401", "GO:0016020"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_IIA_fruc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004716": {"description": "Phosphotransferase system, glucitol/sorbitol-specific IIA component", "go_ids": ["GO:0005737", "GO:0008982", "GO:0009401"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PTS_IIA_glucitol/sorbitol-sp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004718": {"description": "Phosphotransferase system, mannitol-specific enzyme IIC", "go_ids": ["GO:0008982", "GO:0009401", "GO:0016020"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_IIC_mtl", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004719": {"description": "Phosphotransferase system, maltose/glucose-specific subfamily IIC component", "go_ids": ["GO:0008982", "GO:0009401", "GO:0016020"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_maltose/Glc_sub_IIC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004720": {"description": "Phosphotransferase system, sorbose subfamily IIB component", "go_ids": ["GO:0005737", "GO:0008982", "GO:0009401"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PTS_IIB_sorbose-sp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004721": {"description": "Dihydroorotase homodimeric type", "go_ids": ["GO:0004151", "GO:0019856"], "go_terms": ["GO:0004151:dihydroorotase activity:F", "GO:0019856:pyrimidine nucleobase biosynthetic process:P"], "name": "DHOdimr", "pathway_ids": ["PWY-7791", "PWY-5686", "PWY-7790"], "pathways": ["PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II"], "type": "Family"}, "IPR004723": {"description": "8-amino-7-oxononanoate synthase, Archaea/Proteobacteria type", "go_ids": ["GO:0008710", "GO:0009102"], "go_terms": ["GO:0008710:8-amino-7-oxononanoate synthase activity:F", "GO:0009102:biotin biosynthetic process:P"], "name": "AONS_Archaea/Proteobacteria", "pathway_ids": ["PWY-6578", "PWY-6519", "PWY-8203", "PWY-7147"], "pathways": ["PWY-6578:t:8-amino-7-oxononanoate biosynthesis III", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7147:t:8-amino-7-oxononanoate biosynthesis II"], "type": "Family"}, "IPR004724": {"description": "Epithelial sodium channel, chordates", "go_ids": ["GO:0006814", "GO:0015280", "GO:0016020"], "go_terms": ["GO:0006814:sodium ion transport:P", "GO:0015280:ligand-gated sodium channel activity:F", "GO:0016020:membrane:C"], "name": "ENaC_chordates", "pathway_ids": ["R-BTA-9730628", "R-RNO-2672351", "R-MMU-2672351", "R-GGA-2672351", "R-CFA-9730628", "R-MMU-9730628", "R-DRE-2672351", "R-HSA-2672351", "R-HSA-9730628", "R-CFA-2672351", "R-RNO-9730628", "R-BTA-2672351"], "pathways": ["R-BTA-9730628:r:Sensory perception of salty taste", "R-RNO-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-GGA-2672351:r:Stimuli-sensing channels", "R-CFA-9730628:r:Sensory perception of salty taste", "R-MMU-9730628:r:Sensory perception of salty taste", "R-DRE-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9730628:r:Sensory perception of salty taste", "R-CFA-2672351:r:Stimuli-sensing channels", "R-RNO-9730628:r:Sensory perception of salty taste", "R-BTA-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR004725": {"description": "Apoptosis regulator, Bcl-2/ BclX", "go_ids": ["GO:0016020", "GO:0042981"], "go_terms": ["GO:0016020:membrane:C", "GO:0042981:regulation of apoptotic process:P"], "name": "Bcl2/BclX", "pathway_ids": ["R-HSA-9702518", "R-MMU-844455", "R-MMU-9648002", "R-HSA-111447", "R-RNO-844455", "R-HSA-6785807", "R-HSA-9634638", "R-GGA-844455", "R-MMU-111453", "R-RNO-111453", "R-MMU-111447", "R-HSA-9818030", "R-HSA-111453", "R-GGA-111453", "R-RNO-9648002", "R-HSA-9824594", "R-HSA-9648002", "R-HSA-844455", "R-HSA-9018519", "R-HSA-9692913"], "pathways": ["R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-MMU-844455:r:The NLRP1 inflammasome", "R-MMU-9648002:r:RAS processing", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-RNO-844455:r:The NLRP1 inflammasome", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-GGA-844455:r:The NLRP1 inflammasome", "R-MMU-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-RNO-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-GGA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-RNO-9648002:r:RAS processing", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9648002:r:RAS processing", "R-HSA-844455:r:The NLRP1 inflammasome", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death"], "type": "Family"}, "IPR004726": {"description": "Degenerin", "go_ids": ["GO:0005216", "GO:0006811", "GO:0016020"], "go_terms": ["GO:0005216:monoatomic ion channel activity:F", "GO:0006811:monoatomic ion transport:P", "GO:0016020:membrane:C"], "name": "Deg-1", "pathway_ids": ["R-CEL-2672351", "R-CEL-9730628"], "pathways": ["R-CEL-2672351:r:Stimuli-sensing channels", "R-CEL-9730628:r:Sensory perception of salty taste"], "type": "Family"}, "IPR004727": {"description": "Calcium-activated chloride channel protein, chordata", "go_ids": ["GO:0005229", "GO:0006821"], "go_terms": ["GO:0005229:intracellularly calcium-gated chloride channel activity:F", "GO:0006821:chloride transport:P"], "name": "CLCA_chordata", "pathway_ids": ["R-MMU-2672351", "R-HSA-2672351"], "pathways": ["R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR004728": {"description": "Translocation protein Sec62", "go_ids": ["GO:0015031", "GO:0005789"], "go_terms": ["GO:0015031:protein transport:P", "GO:0005789:endoplasmic reticulum membrane:C"], "name": "Sec62", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004730": {"description": "Transaldolase type 1", "go_ids": ["GO:0004801", "GO:0005737", "GO:0006098"], "go_terms": ["GO:0004801:transaldolase activity:F", "GO:0005737:cytoplasm:C", "GO:0006098:pentose-phosphate shunt:P"], "name": "Transaldolase_1", "pathway_ids": ["PWY-1861", "PWY-5723", "R-MMU-71336", "R-RNO-163754", "R-SPO-163754", "R-HSA-71336", "R-SSC-71336", "R-HSA-6791055", "R-DDI-163754", "R-DDI-71336", "R-HSA-8950505", "R-RNO-71336", "R-MMU-163754", "R-HSA-9818028", "R-SCE-71336", "R-DME-71336", "R-SSC-163754", "R-HSA-6791462", "R-SCE-163754", "R-DME-163754", "R-HSA-163754", "R-SPO-71336"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-5723:t:Rubisco shunt", "R-MMU-71336:r:Pentose phosphate pathway", "R-RNO-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-SPO-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-HSA-71336:r:Pentose phosphate pathway", "R-SSC-71336:r:Pentose phosphate pathway", "R-HSA-6791055:r:TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P", "R-DDI-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-DDI-71336:r:Pentose phosphate pathway", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-71336:r:Pentose phosphate pathway", "R-MMU-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-SCE-71336:r:Pentose phosphate pathway", "R-DME-71336:r:Pentose phosphate pathway", "R-SSC-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-HSA-6791462:r:TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P", "R-SCE-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-DME-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-HSA-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-SPO-71336:r:Pentose phosphate pathway"], "type": "Family"}, "IPR004731": {"description": "Transaldolase type 3B/Fructose-6-phosphate aldolase", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "Transaldolase_3B/F6P_aldolase", "pathway_ids": ["PWY-1861", "PWY-5723"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-5723:t:Rubisco shunt"], "type": "Family"}, "IPR004732": {"description": "Transaldolase type 2", "go_ids": ["GO:0004801", "GO:0005737", "GO:0006098"], "go_terms": ["GO:0004801:transaldolase activity:F", "GO:0005737:cytoplasm:C", "GO:0006098:pentose-phosphate shunt:P"], "name": "Transaldolase_2", "pathway_ids": ["PWY-1861", "PWY-5723"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-5723:t:Rubisco shunt"], "type": "Family"}, "IPR004733": {"description": "Phosphoribosylformylglycinamidine cyclo-ligase", "go_ids": ["GO:0004641", "GO:0006189"], "go_terms": ["GO:0004641:phosphoribosylformylglycinamidine cyclo-ligase activity:F", "GO:0006189:'de novo' IMP biosynthetic process:P"], "name": "PurM_cligase", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-BTA-73817", "R-MMU-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817", "R-GGA-419140"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Family"}, "IPR004736": {"description": "MFS transporter, metabolite:H symporter", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "MHS_symport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004737": {"description": "Nitrate transporter NarK/NarU-like", "go_ids": ["GO:0016020", "GO:0015112", "GO:0015113", "GO:0015706", "GO:0015707"], "go_terms": ["GO:0016020:membrane:C", "GO:0015112:nitrate transmembrane transporter activity:F", "GO:0015113:nitrite transmembrane transporter activity:F", "GO:0015706:nitrate transmembrane transport:P", "GO:0015707:nitrite transport:P"], "name": "NO3_transporter_NarK/NarU-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004738": {"description": "Phosphate permease", "go_ids": ["GO:0005315", "GO:0006817", "GO:0016020"], "go_terms": ["GO:0005315:phosphate transmembrane transporter activity:F", "GO:0006817:phosphate ion transport:P", "GO:0016020:membrane:C"], "name": "Phos_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004739": {"description": "GMP synthase, glutamine amidotransferase", "go_ids": ["GO:0003922", "GO:0005524", "GO:0006177"], "go_terms": ["GO:0003922:GMP synthase (glutamine-hydrolyzing) activity:F", "GO:0005524:ATP binding:F", "GO:0006177:GMP biosynthetic process:P"], "name": "GMP_synth_GATase", "pathway_ids": ["PWY-7221", "R-MMU-9748787", "R-SPO-73817", "R-SCE-9748787", "R-DDI-73817", "R-HSA-9748787", "R-CEL-9748787", "R-DDI-9748787", "R-SCE-73817", "R-MMU-73817", "R-CEL-73817", "R-HSA-73817", "R-RNO-73817", "R-SPO-9748787", "R-PFA-73817", "R-RNO-9748787", "R-PFA-9748787"], "pathways": ["PWY-7221:t:guanosine ribonucleotides de novo biosynthesis", "R-MMU-9748787:r:Azathioprine ADME", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-9748787:r:Azathioprine ADME", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-9748787:r:Azathioprine ADME", "R-DDI-9748787:r:Azathioprine ADME", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-9748787:r:Azathioprine ADME", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-9748787:r:Azathioprine ADME", "R-PFA-9748787:r:Azathioprine ADME"], "type": "Domain"}, "IPR004740": {"description": "Nucleoside:H+ symporter", "go_ids": ["GO:0005337", "GO:0015858", "GO:0016020"], "go_terms": ["GO:0005337:nucleoside transmembrane transporter activity:F", "GO:0015858:nucleoside transport:P", "GO:0016020:membrane:C"], "name": "Nuc_H_symport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004741": {"description": "Oxalate/formate antiporter family transporter", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "Oxa_For_antiport_fam_transptr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004742": {"description": "Sialic acid transporter", "go_ids": ["GO:0016020", "GO:0015739", "GO:0015136"], "go_terms": ["GO:0016020:membrane:C", "GO:0015739:sialic acid transport:P", "GO:0015136:sialic acid transmembrane transporter activity:F"], "name": "SA_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004743": {"description": "Monocarboxylate transporter", "go_ids": ["GO:0016020", "GO:0008028", "GO:0015718"], "go_terms": ["GO:0016020:membrane:C", "GO:0008028:monocarboxylic acid transmembrane transporter activity:F", "GO:0015718:monocarboxylic acid transport:P"], "name": "MCT", "pathway_ids": ["R-RNO-210991", "R-MMU-210991", "R-MMU-433692", "R-GGA-210991", "R-HSA-433692", "R-HSA-9749641", "R-RNO-9749641", "R-GGA-373920", "R-MMU-9749641", "R-HSA-5619070", "R-RNO-433692", "R-GGA-433692", "R-HSA-210991"], "pathways": ["R-RNO-210991:r:Basigin interactions", "R-MMU-210991:r:Basigin interactions", "R-MMU-433692:r:Proton-coupled monocarboxylate transport", "R-GGA-210991:r:Basigin interactions", "R-HSA-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-9749641:r:Aspirin ADME", "R-RNO-9749641:r:Aspirin ADME", "R-GGA-373920:r:Pyruvate metabolism", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-5619070:r:Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)", "R-RNO-433692:r:Proton-coupled monocarboxylate transport", "R-GGA-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-210991:r:Basigin interactions"], "type": "Family"}, "IPR004745": {"description": "Na-dependent inorganic phosphate cotransporter", "go_ids": ["GO:0016020", "GO:0005315", "GO:0035435"], "go_terms": ["GO:0016020:membrane:C", "GO:0005315:phosphate transmembrane transporter activity:F", "GO:0035435:phosphate ion transmembrane transport:P"], "name": "Pi_cotranspt", "pathway_ids": ["R-MMU-427652", "R-RNO-427652", "R-HSA-427652", "R-DME-427652", "R-DME-2672351"], "pathways": ["R-MMU-427652:r:Sodium-coupled phosphate cotransporters", "R-RNO-427652:r:Sodium-coupled phosphate cotransporters", "R-HSA-427652:r:Sodium-coupled phosphate cotransporters", "R-DME-427652:r:Sodium-coupled phosphate cotransporters", "R-DME-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR004746": {"description": "Major facilitator superfamily, aromatic acid:H+ symporter family", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "MFS_AAHS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004747": {"description": "Cyanate transport protein CynX-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "CynX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004748": {"description": "Polyol permease-like", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "Polyol_permease-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004749": {"description": "Organic cation transport protein/SVOP", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Orgcat_transp/SVOP", "pathway_ids": ["R-SSC-9749641", "R-BTA-549127", "R-HSA-442660", "R-MMU-181430", "R-SSC-442660", "R-RNO-442660", "R-RNO-9793528", "R-MMU-442660", "R-RNO-200425", "R-MMU-9749641", "R-HSA-561048", "R-SSC-561048", "R-RNO-112311", "R-SSC-112311", "R-BTA-181430", "R-SSC-2161517", "R-SSC-181430", "R-HSA-181430", "R-MMU-200425", "R-BTA-112311", "R-RNO-181430", "R-BTA-9793528", "R-MMU-2161517", "R-HSA-2161517", "R-RNO-2161517", "R-MMU-9793528", "R-MMU-112311", "R-MMU-561048", "R-RNO-561048", "R-HSA-5619053", "R-BTA-2161517", "R-BTA-442660", "R-HSA-200425", "R-HSA-9749641", "R-HSA-9793528", "R-HSA-549127", "R-RNO-9749641", "R-SSC-549127", "R-MMU-549127", "R-HSA-112311", "R-RNO-549127"], "pathways": ["R-SSC-9749641:r:Aspirin ADME", "R-BTA-549127:r:SLC-mediated transport of organic cations", "R-HSA-442660:r:SLC-mediated transport of neurotransmitters", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SSC-442660:r:SLC-mediated transport of neurotransmitters", "R-RNO-442660:r:SLC-mediated transport of neurotransmitters", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-MMU-442660:r:SLC-mediated transport of neurotransmitters", "R-RNO-200425:r:Carnitine shuttle", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-561048:r:Organic anion transport by SLC22 transporters", "R-SSC-561048:r:Organic anion transport by SLC22 transporters", "R-RNO-112311:r:Neurotransmitter clearance", "R-SSC-112311:r:Neurotransmitter clearance", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SSC-2161517:r:Abacavir transmembrane transport", "R-SSC-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-200425:r:Carnitine shuttle", "R-BTA-112311:r:Neurotransmitter clearance", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-BTA-9793528:r:Ciprofloxacin ADME", "R-MMU-2161517:r:Abacavir transmembrane transport", "R-HSA-2161517:r:Abacavir transmembrane transport", "R-RNO-2161517:r:Abacavir transmembrane transport", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-MMU-112311:r:Neurotransmitter clearance", "R-MMU-561048:r:Organic anion transport by SLC22 transporters", "R-RNO-561048:r:Organic anion transport by SLC22 transporters", "R-HSA-5619053:r:Defective SLC22A5 causes systemic 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"R-BTA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR004791": {"description": "UvrABC system, subunit C", "go_ids": ["GO:0009380", "GO:0006289", "GO:0009381"], "go_terms": ["GO:0009380:excinuclease repair complex:C", "GO:0006289:nucleotide-excision repair:P", "GO:0009381:excinuclease ABC activity:F"], "name": "UvrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004792": {"description": "3-Dehydro-bile acid delta(4,6)-reductase-like", "go_ids": [], "go_terms": [], "name": "BaiN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004793": {"description": "Desulfoferrodoxin", "go_ids": ["GO:0005506", "GO:0019430"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0019430:removal of superoxide radicals:P"], "name": 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{"description": "Phosphosugar isomerase, KdsD/KpsF-type", "go_ids": ["GO:0005975", "GO:0016853"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016853:isomerase activity:F"], "name": "KdsD/KpsF-type", "pathway_ids": ["PWY-7674", "PWY-1269"], "pathways": ["PWY-7674:t:CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis", "PWY-1269:t:CMP-3-deoxy-D-manno-octulosonate biosynthesis"], "type": "Family"}, "IPR004801": {"description": "Phosphotransferase system, lactose-specific IIC component", "go_ids": ["GO:0008982", "GO:0016020", "GO:0022869"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0016020:membrane:C", "GO:0022869:protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity:F"], "name": "LacE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004802": {"description": "tRNA pseudouridine synthase B family", "go_ids": ["GO:0006396"], "go_terms": ["GO:0006396:RNA 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"Family"}, "IPR004806": {"description": "UV excision repair protein Rad23", "go_ids": ["GO:0006289"], "go_terms": ["GO:0006289:nucleotide-excision repair:P"], "name": "Rad23", "pathway_ids": ["R-HSA-532668", "R-DDI-5696395", "R-BTA-5696394", "R-RNO-5696395", "R-BTA-5689877", "R-SPO-5696394", "R-RNO-5696394", "R-SPO-5696395", "R-MMU-5696395", "R-MMU-5689877", "R-RNO-5689877", "R-DDI-5696394", "R-RNO-532668", "R-HSA-5696395", "R-HSA-5696394", "R-MMU-5696394", "R-MMU-532668", "R-BTA-5696395", "R-BTA-532668", "R-HSA-5689877"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5689877:r:Josephin domain DUBs", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", 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"IPR004839": {"description": "Aminotransferase, class I/classII, large domain", "go_ids": ["GO:0009058", "GO:0030170"], "go_terms": ["GO:0009058:biosynthetic process:P", "GO:0030170:pyridoxal phosphate binding:F"], "name": "Aminotransferase_I/II_large", "pathway_ids": ["R-HSA-71240", "R-HSA-1989781", "R-HSA-8963684", "R-HSA-2151201", "R-DDI-8964539", "R-HSA-9856872", "R-GGA-8963693", "R-DDI-71064", "R-SPO-189451", "R-SCE-8964208", "R-HSA-1237112", "R-RNO-70268", "R-RNO-8963684", "R-HSA-71064", "R-BTA-8963693", "R-BTA-9856872", "R-SCE-389661", "R-SCE-8963693", "R-SPO-8964208", "R-BTA-8964539", "R-RNO-8964540", "R-SPO-71064", "R-RNO-8963693", "R-HSA-8963693", "R-DDI-389661", "R-RNO-389661", "R-GGA-352875", "R-HSA-389661", "R-SCE-189451", "R-CEL-9856872", "R-SCE-9856872", "R-SCE-71064", "R-BTA-389661", "R-SPO-71240", "R-HSA-8964539", "R-SPO-8964539", "R-SSC-8963693", "R-DDI-70268", "R-SSC-9856872", "R-MMU-8963693", "R-DDI-8963693", "R-DDI-8964208", "R-BTA-189451", "R-XTR-8964540", "R-HSA-189451", "R-SCE-70268", "R-RNO-189451", "R-MMU-9837999", "R-SCE-71240", "R-SPO-70268", "R-DDI-8964540", "R-HSA-1614558", "R-SPO-8964540", "R-DDI-9856872", "R-DRE-189451", "R-RNO-8964539", "R-MMU-8963684", "R-SSC-389661", "R-MMU-389661", "R-GGA-421984", "R-HSA-9837999", "R-SSC-8964539", "R-RNO-71240", "R-CEL-8963693", "R-SPO-9856872", "R-MMU-70268", "R-BTA-8963684", "R-SPO-8963693", "R-MMU-71064", "R-MMU-8964539", "R-MMU-189451", "R-DRE-8964540", "R-MMU-71240", "R-HSA-8964208", "R-DDI-71240", "R-HSA-1660661", "R-RNO-9837999", "R-XTR-70268", "R-CEL-8963684", "R-DDI-8963684", "R-HSA-70268", "R-RNO-71064", "R-BTA-1660661", "R-GGA-9856872", "R-MMU-8964208", "R-RNO-8964208", "R-HSA-8964540", "R-DRE-70268", "R-SCE-8964540", "R-SPO-389661", "R-MMU-9856872", "R-RNO-1660661", "R-SCE-8964539", "R-RNO-9856872", "R-GGA-372568", "R-MMU-8964540", "R-MMU-1660661"], "pathways": ["R-HSA-71240:r:Tryptophan catabolism", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-8963684:r:Tyrosine 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metabolism", "R-DDI-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-389661:r:Glyoxylate metabolism and glycine degradation", "R-GGA-352875:r:Gluconeogenesis", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-SCE-189451:r:Heme biosynthesis", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-SCE-9856872:r:Malate-aspartate shuttle", "R-SCE-71064:r:Lysine catabolism", "R-BTA-389661:r:Glyoxylate metabolism and glycine degradation", "R-SPO-71240:r:Tryptophan catabolism", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-SPO-8964539:r:Glutamate and glutamine metabolism", "R-SSC-8963693:r:Aspartate and asparagine metabolism", "R-DDI-70268:r:Pyruvate metabolism", "R-SSC-9856872:r:Malate-aspartate shuttle", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-DDI-8963693:r:Aspartate and asparagine metabolism", "R-DDI-8964208:r:Phenylalanine metabolism", "R-BTA-189451:r:Heme biosynthesis", "R-XTR-8964540:r:Alanine metabolism", "R-HSA-189451:r:Heme 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"R-HSA-5619087:r:Defective SLC12A3 causes Gitelman syndrome (GS)", "R-MMU-426117:r:Cation-coupled Chloride cotransporters", "R-CEL-426117:r:Cation-coupled Chloride cotransporters", "R-HSA-5619104:r:Defective SLC12A1 causes Bartter syndrome 1 (BS1)", "R-HSA-5619039:r:Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)", "R-SPO-426117:r:Cation-coupled Chloride cotransporters"], "type": "Domain"}, "IPR004842": {"description": "SLC12A transporter family", "go_ids": ["GO:0015377", "GO:0016020", "GO:0006811"], "go_terms": ["GO:0015377:chloride:monoatomic cation symporter activity:F", "GO:0016020:membrane:C", "GO:0006811:monoatomic ion transport:P"], "name": "SLC12A_fam", "pathway_ids": ["R-RNO-426117", "R-SCE-426117", "R-HSA-426117", "R-DRE-426117", "R-HSA-5619087", "R-CEL-426117", "R-MMU-426117", "R-HSA-5619104", "R-HSA-5619039", "R-SPO-426117"], "pathways": ["R-RNO-426117:r:Cation-coupled Chloride cotransporters", "R-SCE-426117:r:Cation-coupled 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"R-MMU-9860927", "R-RNO-6798695", "R-HSA-5625900", "R-HSA-2467813", "R-HSA-5685942", "R-HSA-5607763", "R-DME-2995383", "R-BTA-195253", "R-MMU-1834949", "R-XTR-9770562", "R-SSC-202670", "R-DME-5625740", "R-XTR-5627123", "R-DME-209396", "R-RNO-2025928", "R-HSA-68877", "R-RNO-5685938", "R-SSC-5627123", "R-GGA-9770562", "R-HSA-4086398", "R-SSC-195253", "R-SSC-2995383", "R-SSC-9860927", "R-GGA-351442", "R-HSA-5693568", "R-DME-389513", "R-MMU-195253", "R-SSC-9648025", "R-HSA-389513", "R-MMU-5693607", "R-DME-209360", "R-RNO-68877", "R-MMU-975957", "R-MMU-6804757", "R-MMU-113501", "R-BTA-1295596", "R-HSA-2995383", "R-DME-350480", "R-DDI-2500257", "R-DME-432626", "R-BTA-198753", "R-HSA-9726842", "R-XTR-180024", "R-RNO-69273", "R-RNO-69231", "R-SCE-8939211", "R-HSA-5693571", "R-HSA-975957", "R-RNO-9770562", "R-HSA-5663220", "R-SSC-9770562", "R-HSA-5693579", "R-CEL-2871809", "R-RNO-195253", "R-SSC-180024", "R-RNO-5627123", "R-DME-209155", "R-BTA-69231", "R-MMU-204005", "R-SSC-198753", "R-RNO-2995383", "R-CEL-975957", "R-DME-69231", "R-HSA-432142", "R-MMU-5693616", "R-MMU-1295596", "R-SSC-6811558", "R-MMU-389356", "R-MMU-9833482", "R-HSA-9709570", "R-BTA-2995383", "R-BTA-2871809", "R-RNO-5625740", "R-CEL-5685939", "R-MMU-5693568", "R-CEL-1834949", "R-SPO-5685939", "R-CEL-2500257", "R-RNO-975957", "R-SPO-2500257", "R-HSA-5358749", "R-MMU-8939211", "R-HSA-2514859", "R-BTA-432142", "R-RNO-196843", "R-CEL-9833482", "R-HSA-9648025", "R-SCE-2500257", "R-HSA-5467340", "R-DME-350416", "R-SPO-389513", "R-RNO-113501", "R-RNO-389513", "R-HSA-2465910", "R-HSA-9704331", "R-SPO-202670", "R-SSC-113501", "R-HSA-5693554", "R-HSA-5693548", "R-HSA-9860927", "R-RNO-5693616", "R-HSA-2559586", "R-SCE-198753", "R-MMU-69231", "R-DDI-9840310", "R-HSA-5358751", "R-MMU-196807", "R-RNO-74259", "R-DDI-69273", "R-BTA-389356", "R-SSC-68877", "R-SCE-2559586", "R-DDI-9770562", "R-DME-9860927", "R-DME-195253", "R-DME-209214", "R-DME-6811558", "R-HSA-2025928", "R-DRE-2393930", "R-SCE-5693565", "R-BTA-2467813", "R-SCE-975957", "R-MMU-5607763", "R-DME-2871809", "R-HSA-5339716", "R-DDI-389513", "R-RNO-6804756", "R-DME-5607763", "R-MMU-9648025", "R-SSC-141444", "R-CEL-5693548", "R-SSC-69273", "R-BTA-69273", "R-RNO-2559586", "R-MMU-5685942", "R-XTR-68877", "R-HSA-163560", "R-RNO-204005", "R-RNO-389356", "R-RNO-2393930", "R-SPO-2559586", "R-MMU-2871809", "R-BTA-389513", "R-XTR-2565942", "R-MMU-74259", "R-SPO-5693548", "R-RNO-198753", "R-CFA-180024", "R-BTA-141444", "R-HSA-5627117", "R-HSA-5675221"], "pathways": ["R-MMU-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-SSC-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SSC-9833482:r:PKR-mediated signaling", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-CEL-8939211:r:ESR-mediated signaling", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-4086398:r:Ca2+ pathway", "R-DDI-198753:r:ERK/MAPK targets", "R-XTR-5625740:r:RHO GTPases activate PKNs", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-HSA-202670:r:ERKs are inactivated", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-5673000:r:RAF activation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-202670:r:ERKs are inactivated", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-389356:r:Co-stimulation by CD28", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-BTA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5673000:r:RAF activation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CFA-9770562:r:mRNA Polyadenylation", "R-HSA-912446:r:Meiotic recombination", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SCE-9840310:r:Glycosphingolipid catabolism", "R-MMU-202670:r:ERKs are inactivated", "R-PFA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-9701192:r:Defective homologous 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CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-SCE-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-MMU-198753:r:ERK/MAPK targets", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-BTA-202670:r:ERKs are inactivated", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-69273:r:Cyclin A/B1/B2 associated 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unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-BTA-196299:r:Beta-catenin phosphorylation cascade", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-SPO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-5673000:r:RAF activation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SPO-198753:r:ERK/MAPK targets", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-180024:r:DARPP-32 events", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-180024:r:DARPP-32 events", "R-DME-4086398:r:Ca2+ pathway", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-209190:r:Phosphorylation of CI", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-DDI-202670:r:ERKs are inactivated", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-4086398:r:Ca2+ pathway", "R-BTA-180024:r:DARPP-32 events", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-SPO-9840310:r:Glycosphingolipid catabolism", "R-BTA-2025928:r:Calcineurin activates NFAT", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-RNO-8939211:r:ESR-mediated signaling", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-5673000:r:RAF activation", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-4086398:r:Ca2+ pathway", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-2025928:r:Calcineurin activates NFAT", "R-RNO-73621:r:Pyrimidine catabolism", "R-CEL-5673000:r:RAF activation", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-69231:r:Cyclin D associated events in G1", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-HSA-5673000:r:RAF activation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-74259:r:Purine catabolism", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-SSC-196299:r:Beta-catenin phosphorylation cascade", "R-SSC-5625740:r:RHO GTPases activate PKNs", "R-CEL-69231:r:Cyclin D associated events in G1", "R-RNO-5673000:r:RAF activation", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-198753:r:ERK/MAPK targets", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-DME-538898:r:Dephosphorylation of TIM", "R-SSC-389356:r:Co-stimulation by CD28", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-BTA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-SCE-202670:r:ERKs are inactivated", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-432142:r:Platelet sensitization by LDL", "R-HSA-73621:r:Pyrimidine catabolism", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-180024:r:DARPP-32 events", "R-RNO-196807:r:Nicotinate metabolism", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-DME-432620:r:Dephosphorylation of PER", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-9833482:r:PKR-mediated signaling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-XTR-9770562:r:mRNA Polyadenylation", 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associated events in G1", "R-HSA-432142:r:Platelet sensitization by LDL", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-BTA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-CEL-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-CEL-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SPO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-8939211:r:ESR-mediated signaling", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-432142:r:Platelet sensitization by LDL", "R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-DME-350416:r:Regulation of non-muscle Myosin II", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-SPO-202670:r:ERKs are inactivated", "R-SSC-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SCE-198753:r:ERK/MAPK targets", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-MMU-196807:r:Nicotinate metabolism", "R-RNO-74259:r:Purine catabolism", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-389356:r:Co-stimulation by CD28", "R-SSC-68877:r:Mitotic Prometaphase", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-9770562:r:mRNA Polyadenylation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-209214:r:Phosphorylation of SMO", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-DRE-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-5693548:r:Sensing of DNA Double Strand Breaks", "R-SSC-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-XTR-68877:r:Mitotic Prometaphase", "R-HSA-163560:r:Triglyceride catabolism", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-389356:r:Co-stimulation by CD28", "R-RNO-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-74259:r:Purine catabolism", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-198753:r:ERK/MAPK targets", "R-CFA-180024:r:DARPP-32 events", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR004846": {"description": "Type II/III secretion system, secretin-like domain", "go_ids": ["GO:0009306"], "go_terms": ["GO:0009306:protein secretion:P"], "name": "T2SS/T3SS_dom", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR004847": {"description": "Na(+)/H(+) antiporter subunit E1", "go_ids": ["GO:0015297", "GO:0016020", "GO:1902600"], "go_terms": ["GO:0015297:antiporter activity:F", "GO:0016020:membrane:C", "GO:1902600:proton transmembrane 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"R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Domain"}, "IPR004852": {"description": "Di-haem cytochrome c peroxidase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Di-haem_cyt_c_peroxidsae", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004853": {"description": "Sugar phosphate transporter domain", "go_ids": [], "go_terms": [], "name": "Sugar_P_trans_dom", "pathway_ids": ["R-SPO-727802", "R-CEL-2022928", "R-HSA-5579020", "R-BTA-727802", "R-DME-727802", "R-HSA-727802", "R-SPO-6787639", "R-DDI-727802", "R-CEL-2022854", "R-MMU-2022854", "R-HSA-5619078", "R-MMU-727802", "R-MMU-173599", "R-HSA-6787639", "R-BTA-173599", "R-DME-173599", "R-DME-6787639", "R-DDI-6787639", "R-DME-2022928", "R-HSA-2022854", "R-BTA-6787639", "R-CEL-173599", "R-CEL-727802", "R-MMU-2022928", "R-HSA-2022928", "R-DME-2022854", "R-MMU-6787639", "R-HSA-173599", "R-CEL-6787639"], "pathways": ["R-SPO-727802:r:Transport of nucleotide sugars", 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"R-HSA-167162", "R-SCE-6807505", "R-DME-73776", "R-SPO-76042", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-DDI-9018519", "R-MMU-73776", "R-DDI-76042", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-HSA-9018519", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-DME-674695", "R-DDI-73779", "R-RNO-76042", "R-DME-9018519", "R-SPO-9018519", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-HSA-167161", "R-SCE-9018519", "R-DME-6807505", "R-MMU-9018519", "R-SCE-674695", "R-SPO-73779", "R-HSA-674695", "R-HSA-76042", "R-DDI-75953", "R-SPO-73776", "R-RNO-75953", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167161:r:HIV Transcription Initiation", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Family"}, "IPR004856": {"description": "Glycosyl transferase, ALG6/ALG8", "go_ids": ["GO:0016758"], "go_terms": ["GO:0016758:hexosyltransferase activity:F"], "name": "Glyco_trans_ALG6/ALG8", "pathway_ids": ["R-HSA-4724289", "R-SCE-446193", "R-MMU-446193", "R-DME-446193", "R-CEL-446193", "R-RNO-446193", "R-DDI-446193", "R-HSA-4724325", "R-SPO-446193", "R-GGA-446193", "R-HSA-446193"], "pathways": ["R-HSA-4724289:r:Defective ALG6 causes CDG-1c", "R-SCE-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DME-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-CEL-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-RNO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DDI-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-4724325:r:Defective ALG8 causes CDG-1h", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-GGA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Family"}, "IPR004858": {"description": "Multigene family 505", "go_ids": [], "go_terms": [], "name": "MGF_505", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004859": {"description": "Xrn1, N-terminal", "go_ids": ["GO:0003676", "GO:0004527"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0004527:exonuclease activity:F"], "name": "Xrn1_N", "pathway_ids": ["R-MMU-450385", "R-MMU-6791226", "R-HSA-450385", "R-HSA-9930044", "R-MMU-450513", "R-HSA-9770562", "R-HSA-390471", "R-HSA-6791226", "R-HSA-450513", "R-SCE-450513", "R-GGA-6791226", "R-HSA-9918487", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-GGA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR004860": {"description": "Homing endonuclease, LAGLIDADG domain", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "LAGLIDADG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004861": {"description": "Atypical dual-specificity phosphatase Siw14-like", "go_ids": [], "go_terms": [], "name": "Siw14-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004864": {"description": "Late embryogenesis abundant protein, LEA_2 subgroup", "go_ids": [], "go_terms": [], "name": "LEA_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004865": {"description": "HSR domain", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "HSR_dom", "pathway_ids": ["R-HSA-3108214", "R-HSA-877300"], "pathways": ["R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-877300:r:Interferon gamma signaling"], "type": "Domain"}, "IPR004866": {"description": "Chitobiase/beta-hexosaminidases, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CHB/HEX_N_dom", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-7883"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-7883:t:peptidoglycan recycling II"], "type": "Domain"}, "IPR004867": {"description": "Chitobiase C-terminal domain", "go_ids": [], "go_terms": [], "name": "CHB_C_dom", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-7883"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-7883:t:peptidoglycan recycling II"], "type": "Domain"}, "IPR004868": {"description": "DNA-directed DNA polymerase, family B, mitochondria/virus", "go_ids": ["GO:0000166", "GO:0003677", "GO:0003887", "GO:0006260"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P"], "name": "DNA-dir_DNA_pol_B_mt/vir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004869": {"description": "Membrane transport protein MMPL domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "MMPL_dom", "pathway_ids": ["R-MTU-9635470"], "pathways": ["R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis"], "type": "Domain"}, "IPR004870": {"description": "Nucleoporin, Nup155-like", "go_ids": ["GO:0005643", "GO:0006913", "GO:0017056"], "go_terms": ["GO:0005643:nuclear pore:C", "GO:0006913:nucleocytoplasmic transport:P", "GO:0017056:structural constituent of nuclear pore:F"], "name": "Nucleoporin_Nup155", "pathway_ids": ["R-HSA-180910", "R-RNO-9615933", "R-RNO-3301854", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-9615933", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-HSA-3371453", "R-RNO-191859", "R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-DME-3371453", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-DME-159227", "R-HSA-168325", "R-MMU-170822", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-RNO-4085377", "R-SPO-4570464", "R-HSA-5619107", "R-RNO-4570464", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-SPO-159227", "R-SPO-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-HSA-168333", "R-MMU-4085377", "R-HSA-165054", "R-RNO-159236", "R-HSA-4615885", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-DME-4551638", "R-HSA-4085377", "R-RNO-159227", "R-RNO-4551638", "R-DME-159230", "R-DME-3301854", "R-RNO-170822", "R-RNO-159231", "R-HSA-180746"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", 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Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Family"}, "IPR004871": {"description": "RSE1/DDB1/CPSF1, C-terminal", "go_ids": ["GO:0003676", "GO:0005634"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0005634:nucleus:C"], "name": "RSE1/DDB1/CPSF1_C", "pathway_ids": ["R-RNO-6781823", "R-CEL-159231", "R-DME-110314", "R-MMU-9770562", "R-HSA-8951664", "R-DME-6781823", "R-DME-8951664", "R-HSA-73856", "R-DME-72163", "R-DDI-6782210", "R-HSA-72187", "R-RNO-110314", "R-DME-5696394", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-110314", "R-MMU-8951664", "R-SPO-5696395", "R-CEL-110314", "R-MMU-5696395", "R-CEL-9770562", "R-MMU-5696394", "R-DME-73856", "R-CEL-5696394", "R-DME-6782135", "R-RNO-6782210", "R-BTA-72163", "R-DRE-77595", "R-MMU-72163", "R-SCE-77595", "R-HSA-6784531", "R-RNO-5696395", "R-DDI-6781823", "R-MMU-73856", "R-CEL-6782210", "R-SPO-77595", "R-RNO-5696394", "R-HSA-159231", "R-CEL-6781823", "R-SPO-9770562", "R-HSA-72163", "R-DME-72165", "R-DDI-5696394", "R-SPO-110314", "R-HSA-5696395", "R-CEL-6782135", "R-HSA-5696394", "R-CEL-5696395", "R-RNO-8951664", "R-BTA-9770562", "R-SPO-8951664", "R-MMU-6782210", "R-HSA-110314", "R-DDI-6782135", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-DME-77595", "R-SPO-159231", "R-MMU-77595", "R-DME-159231", "R-DDI-9770562", "R-CEL-73856", "R-CEL-77595", "R-HSA-77595", "R-DME-9770562", "R-MMU-6781823", "R-DRE-73856", "R-GGA-353303", "R-DRE-9770562", "R-HSA-6782210", "R-HSA-72165", "R-HSA-9918481", "R-MMU-159231", "R-MMU-5696400", "R-BTA-72165", "R-HSA-9770562", "R-RNO-6782135", "R-HSA-6782135", "R-DME-5696395", "R-MMU-72187", "R-SPO-5696400", "R-MMU-72165", "R-DME-5696400", "R-SPO-6782210", "R-RNO-5696400", "R-HSA-5696400", "R-DME-6782210", "R-SPO-6782135", "R-DRE-72165", "R-CEL-8951664"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8951664:r:Neddylation", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-8951664:r:Neddylation", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72187:r:mRNA 3'-end processing", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8951664:r:Neddylation", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-6782135:r:Dual incision in TC-NER", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-8951664:r:Neddylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-SPO-8951664:r:Neddylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-GGA-353303:r:Nucleotide Excision Repair", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-72187:r:mRNA 3'-end processing", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR004872": {"description": "Lipoprotein NlpA family", "go_ids": [], "go_terms": [], "name": "Lipoprotein_NlpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004873": {"description": "BURP domain", "go_ids": [], "go_terms": [], "name": "BURP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004875": {"description": "DDE superfamily endonuclease domain", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "DDE_SF_endonuclease_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004876": {"description": "Corona nucleocapsid I", "go_ids": [], "go_terms": [], "name": "Corona_nucI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004878": {"description": "Otopetrin", "go_ids": ["GO:0015252", "GO:1902600", "GO:0016020"], "go_terms": ["GO:0015252:proton channel activity:F", "GO:1902600:proton transmembrane transport:P", "GO:0016020:membrane:C"], "name": "Otopetrin", "pathway_ids": ["R-HSA-9729555"], "pathways": ["R-HSA-9729555:r:Sensory perception of sour taste"], "type": "Family"}, "IPR004879": {"description": "Spermatogenesis-associated protein 20-like, TRX domain", "go_ids": [], "go_terms": [], "name": "Ssp411-like_TRX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004881": {"description": "Ribosome biogenesis GTPase RsgA", "go_ids": ["GO:0003924", "GO:0005525"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005525:GTP binding:F"], "name": "Ribosome_biogen_GTPase_RsgA", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR004882": {"description": "Luc7-related", "go_ids": ["GO:0003729", "GO:0006376", "GO:0005685"], "go_terms": ["GO:0003729:mRNA binding:F", "GO:0006376:mRNA splice site recognition:P", "GO:0005685:U1 snRNP:C"], "name": "Luc7-rel", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR004883": {"description": "Lateral organ boundaries, LOB", "go_ids": [], "go_terms": [], "name": "LOB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004884": {"description": "Protein of unknown function DUF261", "go_ids": [], "go_terms": [], "name": "DUF261", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004885": {"description": "Frd-Gp32-like", "go_ids": [], "go_terms": [], "name": "Frd-Gp32-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004886": {"description": "Glucanosyltransferase", "go_ids": [], "go_terms": [], "name": "Glucanosyltransferase", "pathway_ids": ["PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219"], "pathways": ["PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis"], "type": "Family"}, "IPR004887": {"description": "Glutathione synthase, substrate-binding domain", "go_ids": ["GO:0004363", "GO:0005524", "GO:0006750"], "go_terms": ["GO:0004363:glutathione synthase activity:F", "GO:0005524:ATP binding:F", "GO:0006750:glutathione biosynthetic process:P"], "name": "GSH_synth_subst-bd", "pathway_ids": ["PWY-8043", "R-RNO-174403", "R-HSA-174403", "R-HSA-5579006", "R-DDI-174403", "R-MMU-174403", "R-SCE-174403", "R-SPO-174403"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-HSA-5579006:r:Defective GSS causes GSS deficiency", "R-DDI-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling"], "type": "Domain"}, "IPR004888": {"description": "Glycoside hydrolase family 63", "go_ids": ["GO:0004573", "GO:0009311"], "go_terms": ["GO:0004573:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity:F", "GO:0009311:oligosaccharide metabolic process:P"], "name": "Glycoside_hydrolase_63", "pathway_ids": ["R-HSA-532668", "R-HSA-9683686", "R-HSA-9768727", "R-RNO-9768727", "R-MMU-9768727", "R-HSA-9694548", "R-HSA-4793954"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational 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{"description": "Nitrogen fixation protein NifW", "go_ids": ["GO:0009399"], "go_terms": ["GO:0009399:nitrogen fixation:P"], "name": "NifW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004894": {"description": "Borrelia outer surface protein D OspD", "go_ids": [], "go_terms": [], "name": "OspD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004895": {"description": "Prenylated rab acceptor PRA1", "go_ids": [], "go_terms": [], "name": "Prenylated_rab_accept_PRA1", "pathway_ids": ["R-MMU-210500", "R-BTA-210500", "R-GGA-210500", "R-RNO-210500", "R-HSA-210500", "R-SSC-210500"], "pathways": ["R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-GGA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SSC-210500:r:Glutamate Neurotransmitter Release Cycle"], "type": "Family"}, "IPR004896": {"description": "PucC-related", "go_ids": [], "go_terms": [], "name": "PucC-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004897": {"description": "P/V phosphoprotein, paramyxoviral", "go_ids": [], "go_terms": [], "name": "P/V_Pprotein_paramyxoviral", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004898": {"description": "Pectate lyase PlyH/PlyE-like", "go_ids": ["GO:0005576", "GO:0030570"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0030570:pectate lyase activity:F"], "name": "Pectate_lyase_PlyH/PlyE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004899": {"description": "Pertactin, central region", "go_ids": [], "go_terms": [], "name": "Pertactin_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004900": {"description": "Poxvirus P35", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Poxvirus_P35", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004901": {"description": "Reversibly glycosylated polypeptide", "go_ids": ["GO:0071669", "GO:0016866"], "go_terms": ["GO:0071669:plant-type cell wall organization or biogenesis:P", "GO:0016866:intramolecular transferase activity:F"], "name": "RGP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004902": {"description": "Rhabdovirus nucleoprotein", "go_ids": [], "go_terms": [], "name": "Rhabdo_ncap_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004903": {"description": "Lactobacillus surface layer protein", "go_ids": ["GO:0005199", "GO:0009274", "GO:0030115"], "go_terms": ["GO:0005199:structural constituent of cell wall:F", "GO:0009274:peptidoglycan-based cell wall:C", "GO:0030115:S-layer:C"], "name": "S-layer_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004905": {"description": "Tombusvirus p19 core protein", "go_ids": ["GO:0044423"], "go_terms": ["GO:0044423:virion component:C"], "name": "Tombusvirus_p19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004907": {"description": "ATPase, V1 complex, subunit C", "go_ids": ["GO:1902600", "GO:0033180", "GO:0046961"], "go_terms": ["GO:1902600:proton transmembrane transport:P", "GO:0033180:proton-transporting V-type ATPase, V1 domain:C", "GO:0046961:proton-transporting ATPase activity, rotational mechanism:F"], "name": "ATPase_V1-cplx_csu", "pathway_ids": ["R-MMU-1222556", "R-CEL-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-DRE-9639288", "R-HSA-9857377", "R-MMU-9639288", "R-XTR-77387", "R-SPO-9639288", "R-RNO-1222556", "R-HSA-9639288", "R-DRE-983712", "R-RNO-983712", "R-XTR-1222556", "R-HSA-1222556", "R-XTR-917977", "R-SPO-917977", "R-DRE-1222556", "R-CEL-9639288", "R-DDI-1222556", "R-SPO-1222556", "R-XTR-983712", "R-RNO-917977", "R-SCE-917977", "R-SCE-1222556", "R-DDI-9639288", "R-BTA-1222556", "R-DRE-917977", "R-SCE-77387", "R-MMU-77387", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-RNO-77387", "R-CEL-77387", "R-BTA-917977", 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"Family"}, "IPR004908": {"description": "ATPase, V1 complex, subunit H", "go_ids": ["GO:0000221", "GO:1902600", "GO:0046961"], "go_terms": ["GO:0000221:vacuolar proton-transporting V-type ATPase, V1 domain:C", "GO:1902600:proton transmembrane transport:P", "GO:0046961:proton-transporting ATPase activity, rotational mechanism:F"], "name": "ATPase_V1-cplx_hsu", "pathway_ids": ["R-CEL-1222556", "R-MMU-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-HSA-9639288", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-SCE-1222556", "R-SCE-917977", "R-MMU-77387", "R-BTA-1222556", "R-DDI-9639288", "R-SCE-77387", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-HSA-167590", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-DDI-917977", "R-MMU-983712", "R-DDI-983712", "R-HSA-917977", "R-BTA-77387", 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recycling", "R-HSA-9636467:r:Blockage of phagosome acidification", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR004909": {"description": "Viral heat shock protein Hsp90 homologue", "go_ids": [], "go_terms": [], "name": "Vir_Hsp90", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004910": {"description": "Yippee/Mis18/Cereblon", "go_ids": [], "go_terms": [], "name": "Yippee/Mis18/Cereblon", "pathway_ids": ["R-HSA-6798695", "R-HSA-606279", "R-SPO-6798695", "R-DME-6798695", "R-RNO-606279", "R-SCE-6798695", "R-MMU-6798695", "R-MMU-606279", "R-BTA-6798695", "R-HSA-9679191", "R-BTA-606279"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere"], "type": "Domain"}, "IPR004911": {"description": "Gamma interferon inducible lysosomal thiol reductase GILT", "go_ids": ["GO:0016671"], "go_terms": ["GO:0016671:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor:F"], "name": "Interferon-induced_GILT", "pathway_ids": ["R-HSA-2132295", "R-RNO-2132295", "R-DRE-2132295", "R-MMU-2132295", "R-HSA-877300", "R-DME-2132295", "R-CEL-2132295", "R-BTA-2132295"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DRE-2132295:r:MHC class II antigen 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"Family"}, "IPR004917": {"description": "Aphid transmission protein", "go_ids": [], "go_terms": [], "name": "Caulimo_AT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004918": {"description": "Cdc37", "go_ids": [], "go_terms": [], "name": "Cdc37", "pathway_ids": ["R-MMU-8863795", "R-DRE-114608", "R-CEL-8863795", "R-CEL-1227986", "R-HSA-9013418", "R-CEL-9652282", "R-HSA-9665251", "R-BTA-1227986", "R-BTA-9652282", "R-DME-9652282", "R-HSA-9665737", "R-SCE-114608", "R-HSA-9665348", "R-SPO-114608", "R-HSA-9665245", "R-RNO-8863795", "R-RNO-114608", "R-HSA-114608", "R-BTA-114608", "R-HSA-8863795", "R-BTA-5675482", "R-HSA-1236382", "R-MMU-9652282", "R-BTA-9013418", "R-DME-8863795", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-9652282", "R-BTA-8863795", "R-RNO-9013418", "R-DME-1227986", "R-HSA-9665244", "R-HSA-9665686", "R-HSA-9665249", "R-HSA-9665246", "R-HSA-5675482", "R-DME-114608", "R-MMU-1227986", "R-HSA-1227986", "R-CEL-114608", "R-HSA-9665233", "R-MMU-5675482", "R-RNO-1227986", "R-HSA-9665250", "R-HSA-5637810", "R-DME-9013418", "R-SPO-9652282", "R-CEL-5675482", "R-HSA-9634285", "R-RNO-9652282", "R-RNO-5675482", "R-MMU-9013418", "R-MMU-114608"], "pathways": ["R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DRE-114608:r:Platelet degranulation", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-1227986:r:Signaling by ERBB2", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-CEL-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-BTA-1227986:r:Signaling by ERBB2", "R-BTA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-SCE-114608:r:Platelet degranulation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-SPO-114608:r:Platelet degranulation", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-DME-114608:r:Platelet degranulation", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-1227986:r:Signaling by ERBB2", "R-CEL-114608:r:Platelet degranulation", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-CEL-5675482:r:Regulation of necroptotic cell death", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR004919": {"description": "GmrSD restriction endonucleases, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GmrSD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004922": {"description": "ESAG protein", "go_ids": [], "go_terms": [], "name": "ESAG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004923": {"description": "Iron permease FTR1/Fip1/EfeU", "go_ids": ["GO:0016020", "GO:0005381", "GO:0033573", "GO:0034755"], "go_terms": ["GO:0016020:membrane:C", "GO:0005381:iron ion transmembrane transporter activity:F", "GO:0033573:high-affinity iron permease complex:C", "GO:0034755:iron ion transmembrane transport:P"], "name": "FTR1/Fip1/EfeU", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR004925": {"description": "HpaB/PvcC/4-BUDH", "go_ids": [], "go_terms": [], "name": "HpaB/PvcC/4-BUDH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004926": {"description": "Late embryogenesis abundant 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"GO:0003723"], "go_terms": ["GO:0019013:viral nucleocapsid:C", "GO:0003723:RNA binding:F"], "name": "Pneumo_ncap", "pathway_ids": ["R-HSA-9833109", "R-HSA-9828721", "R-HSA-9828806", "R-HSA-9820962", "R-HSA-9828642", "R-HSA-9833482", "R-HSA-9833110", "R-HSA-9834752", "R-HSA-9820960"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-9828642:r:Respiratory syncytial virus genome transcription", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9834752:r:Respiratory syncytial virus genome replication", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry"], "type": "Family"}, "IPR004931": {"description": "Prothymosin/parathymosin", "go_ids": [], "go_terms": [], "name": "Pro/parathymosin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004932": {"description": "Retrieval of early ER protein Rer1", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Rer1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004933": {"description": "Type specific antigen", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TSA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004934": {"description": "Tropomodulin", "go_ids": ["GO:0005523", "GO:0051694"], "go_terms": ["GO:0005523:tropomyosin binding:F", "GO:0051694:pointed-end actin filament capping:P"], "name": "TMOD", "pathway_ids": ["R-HSA-445355", "R-RNO-390522", "R-RNO-445355", "R-HSA-9013418", "R-CEL-445355", "R-HSA-390522", "R-MMU-390522", "R-MMU-9696264", "R-MMU-445355", "R-MMU-9013418", "R-BTA-390522", "R-HSA-9696264"], "pathways": ["R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-390522:r:Striated Muscle Contraction", "R-RNO-445355:r:Smooth Muscle Contraction", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-390522:r:Striated Muscle Contraction", "R-MMU-390522:r:Striated Muscle Contraction", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-445355:r:Smooth Muscle Contraction", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-BTA-390522:r:Striated Muscle Contraction", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Family"}, "IPR004935": {"description": "Tymovirus 45/70kDa protein", "go_ids": [], "go_terms": [], "name": "45/70kDa_tymovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004936": {"description": "Herpesvirus UL21", "go_ids": [], "go_terms": [], "name": "Herpes_UL21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004937": {"description": "Urea transporter", "go_ids": ["GO:0015204", "GO:0016020", "GO:0071918"], "go_terms": ["GO:0015204:urea transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0071918:urea transmembrane transport:P"], "name": "Urea_transporter", "pathway_ids": ["R-HSA-549127", "R-MMU-549127", "R-RNO-549127", "R-BTA-549127"], "pathways": ["R-HSA-549127:r:SLC-mediated transport of organic cations", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-RNO-549127:r:SLC-mediated transport of organic cations", "R-BTA-549127:r:SLC-mediated transport of organic cations"], "type": "Family"}, "IPR004938": {"description": "Xyloglucan fucosyltransferase", "go_ids": ["GO:0008107", "GO:0016020", "GO:0042546"], "go_terms": ["GO:0008107:galactoside 2-alpha-L-fucosyltransferase activity:F", "GO:0016020:membrane:C", "GO:0042546:cell wall biogenesis:P"], "name": "XG_FTase", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular 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biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR004939": {"description": "APC10/DOC domain", "go_ids": [], "go_terms": [], "name": "APC_su10/DOC_dom", "pathway_ids": ["R-HSA-174178", "R-DME-176408", "R-HSA-8951664", "R-MMU-2467813", "R-MMU-174154", "R-MMU-69017", "R-DME-176407", "R-HSA-5693565", "R-DDI-179409", "R-MMU-69473", "R-HSA-141430", "R-HSA-5693607", "R-DDI-2559582", "R-DME-2467813", "R-DDI-176407", "R-MMU-174084", "R-HSA-176408", "R-HSA-68867", "R-HSA-176409", "R-MMU-68867", "R-DDI-174084", "R-MMU-176409", "R-SPO-2559582", "R-DME-2559582", "R-DME-174154", "R-DME-174048", "R-HSA-9687136", "R-DME-141430", "R-HSA-69473", "R-DME-179409", "R-MMU-2559582", "R-SPO-179409", "R-DDI-174048", "R-MMU-141430", "R-RNO-8951664", "R-DDI-141430", "R-DME-176409", "R-HSA-174048", "R-HSA-179409", "R-MMU-3108214", "R-RNO-983168", "R-MMU-5693571", "R-HSA-174154", "R-DDI-176408", "R-HSA-8853884", "R-DME-69017", "R-DME-983168", "R-SPO-176408", "R-HSA-2467813", "R-HSA-3108214", "R-MMU-179409", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-MMU-174048", "R-MMU-5693565", "R-DME-174084", "R-DDI-176409", "R-SPO-983168", "R-DDI-2467813", "R-DDI-176412", "R-SCE-983168", "R-HSA-174084", "R-HSA-176407", "R-MMU-5693607", "R-DDI-69017", "R-HSA-176412", "R-MMU-176408", "R-HSA-381038", "R-DME-176412", "R-DME-174184", "R-HSA-983168", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-HSA-5693571", "R-MMU-174184", "R-DDI-174184", "R-HSA-69017", "R-DME-174178", "R-MMU-983168", "R-DDI-174178", "R-DDI-174154", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8951664:r:Neddylation", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-2467813:r:Separation of Sister Chromatids", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DME-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-8951664:r:Neddylation", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-176412:r:Phosphorylation of the APC/C", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR004940": {"description": "Adhesin P1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Adhesin_P1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004941": {"description": "FP protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004942": {"description": "Roadblock/LAMTOR2 domain", "go_ids": [], "go_terms": [], "name": "Roadblock/LAMTOR2_dom", "pathway_ids": ["R-HSA-6798695", "R-MMU-5674135", "R-DRE-5674135", "R-HSA-5674135", "R-MMU-380972", "R-DME-5628897", "R-DRE-8943724", "R-CEL-6798695", "R-DRE-9639288", "R-CEL-1632852", "R-MMU-1632852", "R-MMU-9639288", "R-BTA-6798695", "R-BTA-9639288", "R-DME-380972", "R-HSA-9639288", "R-HSA-5628897", "R-BTA-380972", "R-BTA-5674135", "R-HSA-166208", "R-CEL-8943724", "R-DRE-166208", "R-DRE-6798695", "R-XTR-1632852", "R-DME-166208", "R-XTR-5628897", "R-XTR-166208", "R-HSA-9635465", "R-DRE-1632852", "R-CEL-165159", "R-MMU-5628897", "R-CEL-9639288", "R-HSA-8943724", "R-MMU-5620924", "R-HSA-380972", "R-BTA-8943724", "R-DME-5674135", "R-HSA-5620924", "R-BTA-166208", "R-MMU-165159", "R-DME-6798695", "R-CEL-5628897", "R-BTA-165159", "R-CEL-380972", "R-CEL-5674135", "R-XTR-6798695", "R-BTA-5628897", "R-BTA-1632852", "R-MMU-8943724", "R-XTR-165159", "R-DRE-165159", "R-XTR-9639288", "R-MMU-166208", "R-HSA-1632852", "R-HSA-165159", "R-MMU-6798695", "R-DME-1632852", "R-DME-165159", "R-RNO-5620924", "R-CEL-166208", "R-BTA-5620924", "R-DRE-380972", "R-DME-8943724", "R-XTR-380972", "R-DRE-5628897", "R-DME-9639288"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-8943724:r:Regulation of PTEN gene transcription", "R-CEL-6798695:r:Neutrophil degranulation", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-CEL-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-HSA-166208:r:mTORC1-mediated signalling", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-DRE-166208:r:mTORC1-mediated signalling", "R-DRE-6798695:r:Neutrophil degranulation", "R-XTR-1632852:r:Macroautophagy", "R-DME-166208:r:mTORC1-mediated signalling", "R-XTR-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-166208:r:mTORC1-mediated signalling", "R-HSA-9635465:r:Suppression of apoptosis", "R-DRE-1632852:r:Macroautophagy", "R-CEL-165159:r:MTOR signalling", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-DME-5674135:r:MAP2K and MAPK activation", "R-HSA-5620924:r:Intraflagellar transport", "R-BTA-166208:r:mTORC1-mediated signalling", "R-MMU-165159:r:MTOR signalling", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-165159:r:MTOR signalling", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-XTR-6798695:r:Neutrophil degranulation", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-1632852:r:Macroautophagy", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-XTR-165159:r:MTOR signalling", "R-DRE-165159:r:MTOR signalling", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-MMU-166208:r:mTORC1-mediated signalling", "R-HSA-1632852:r:Macroautophagy", "R-HSA-165159:r:MTOR signalling", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-1632852:r:Macroautophagy", "R-DME-165159:r:MTOR signalling", "R-RNO-5620924:r:Intraflagellar transport", "R-CEL-166208:r:mTORC1-mediated signalling", "R-BTA-5620924:r:Intraflagellar transport", "R-DRE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-XTR-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR004943": {"description": "Lepidopteran low molecular weight lipoprotein", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Lipoprotein_11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004944": {"description": "Cyclin-dependent kinase 5 activator", "go_ids": ["GO:0061575", "GO:0016533"], "go_terms": ["GO:0061575:cyclin-dependent protein serine/threonine kinase activator activity:F", 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{"description": "DNA-directed RNA polymerase, 18kDa subunit, poxviral", "go_ids": ["GO:0003677", "GO:0003899", "GO:0019083"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0019083:viral transcription:P"], "name": "DNA-dir_RNA_pol_18kDa_poxviral", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004974": {"description": "RNA polymerase-associated transcription specificity factor Rap94", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "Pox_Rap94", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004975": {"description": "Poxvirus VLTF2, trans-activator", "go_ids": [], "go_terms": [], "name": "Poxvirus_VLTF2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004976": {"description": "Poly(A) polymerase catalytic subunit, Poxvirus", "go_ids": ["GO:0006397", "GO:1990817"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:1990817:poly(A) RNA polymerase 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"R-RNO-975956", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-SPO-72689", "R-CEL-72689", "R-DDI-72689", "R-DDI-72702", "R-MMU-1799339", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-72695", "R-DME-975957", "R-DME-975956", "R-MMU-72702", "R-BTA-9954716", "R-DRE-975956", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-HSA-72649", "R-MMU-156827", "R-HSA-9754678", "R-BTA-1799339", "R-BTA-9954714", "R-DRE-72649", "R-SCE-72649", "R-HSA-975957", "R-DRE-72702", "R-DME-9954714", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", 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"R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", 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the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", 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{"description": "Stanniocalcin", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Stanniocalcin", "pathway_ids": ["R-RNO-381426", "R-MMU-381426", "R-HSA-8957275", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR004979": {"description": "Transcription factor AP-2", 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"R-BTA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-HSA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-BTA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-CEL-9834899:r:Specification of the neural plate border", "R-MMU-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-HSA-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-CFA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9827857:r:Specification of primordial germ cells", "R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-MMU-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-8866906:r:TFAP2 (AP-2) family regulates transcription of other transcription factors", "R-DRE-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-RNO-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-CEL-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-9834899:r:Specification of the neural plate border", "R-RNO-9834899:r:Specification of the neural plate border", "R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-CEL-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-BTA-9834899:r:Specification of the neural plate border", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-9834899:r:Specification of the neural plate border", "R-MMU-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-BTA-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-CFA-9834899:r:Specification of the neural plate border", "R-BTA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "type": "Family"}, "IPR004980": {"description": "Tenuivirus movement protein, NS4", "go_ids": ["GO:0046740"], "go_terms": ["GO:0046740:transport of virus in host, cell to cell:P"], "name": "Tenui_NS4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004981": {"description": "Tryptophan 2,3-dioxygenase", "go_ids": ["GO:0004833", "GO:0006569", "GO:0020037"], "go_terms": ["GO:0004833:L-tryptophan 2,3-dioxygenase activity:F", "GO:0006569:L-tryptophan catabolic process:P", "GO:0020037:heme binding:F"], "name": "Trp_2_3_dOase", "pathway_ids": ["R-HSA-71240", "R-CEL-71240", "R-DRE-71240", "R-XTR-71240", "R-MMU-71240", "R-DDI-71240", "R-DME-71240", "R-RNO-71240", "R-BTA-71240"], "pathways": ["R-HSA-71240:r:Tryptophan catabolism", "R-CEL-71240:r:Tryptophan catabolism", "R-DRE-71240:r:Tryptophan catabolism", "R-XTR-71240:r:Tryptophan catabolism", "R-MMU-71240:r:Tryptophan catabolism", "R-DDI-71240:r:Tryptophan catabolism", "R-DME-71240:r:Tryptophan catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-BTA-71240:r:Tryptophan catabolism"], "type": "Family"}, "IPR004982": {"description": "WTF family", "go_ids": ["GO:0110134"], "go_terms": ["GO:0110134:meiotic drive:P"], "name": "WTF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004983": {"description": "Mlp lipoprotein", "go_ids": [], "go_terms": [], "name": "Mlp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004984": {"description": "Mycoplasma lipoprotein, central domain", "go_ids": [], "go_terms": [], "name": "Mycoplasma_lipoprotein_cen_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004985": {"description": "Adenovirus E3-15", "go_ids": ["GO:0052031"], "go_terms": ["GO:0052031:symbiont-mediated perturbation of host defense response:P"], "name": "Adeno_E3-15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004986": {"description": "Caulimovirus virion-associated protein", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Caulimo_virion-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004987": {"description": "DUF272, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF272_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR004988": {"description": "Protein of unknown function DUF273", "go_ids": [], "go_terms": [], "name": "DUF273", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004990": {"description": "ELF protein", "go_ids": [], "go_terms": [], "name": "ELF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004991": {"description": "Aerolysin-like toxin", "go_ids": [], "go_terms": [], "name": "Aerolysin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004992": {"description": "Ethanolamine utilization protein EutN/carboxysome shell vertex protein CcmL", "go_ids": ["GO:0031469"], "go_terms": ["GO:0031469:bacterial microcompartment:C"], "name": "EutN_CcmL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004993": {"description": "GH3 family", "go_ids": [], "go_terms": [], "name": "GH3", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565", "R-MMU-6798695", "R-HSA-6798695"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR004995": {"description": "Bacillus/Clostridium Ger spore germination protein", "go_ids": ["GO:0009847", "GO:0016020"], "go_terms": ["GO:0009847:spore germination:P", "GO:0016020:membrane:C"], "name": "Spore_Ger", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004996": {"description": "DNA helicase/primase complex-associated protein", "go_ids": ["GO:0019079"], "go_terms": ["GO:0019079:viral genome replication:P"], "name": "HSV_HEPA", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR004997": {"description": "Herpesvirus polymerase accessory protein", "go_ids": ["GO:0019079", "GO:0030337"], "go_terms": ["GO:0019079:viral genome replication:P", "GO:0030337:DNA polymerase processivity factor activity:F"], "name": "Herpes_PAP", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR004998": {"description": "Herpesvirus transcription activation factor", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Herpes_TAF50", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR004999": {"description": "Herpesvirus capsid shell protein 1", "go_ids": ["GO:0003677", "GO:0019069"], "go_terms": ["GO:0003677:DNA 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"R-HSA-446205", "R-SPO-446205", "R-DME-446205", "R-DDI-446205", "R-MMU-446205", "R-BTA-446205", "R-CEL-446205", "R-SCE-446205", "R-PFA-446205", "R-HSA-4043911"], "pathways": ["PWY-7586:t:beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation", "PWY-7456:t:beta-(1,4)-mannan degradation", "PWY-5659:t:GDP-mannose biosynthesis", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-DME-446205:r:Synthesis of GDP-mannose", "R-DDI-446205:r:Synthesis of GDP-mannose", "R-MMU-446205:r:Synthesis of GDP-mannose", "R-BTA-446205:r:Synthesis of GDP-mannose", "R-CEL-446205:r:Synthesis of GDP-mannose", "R-SCE-446205:r:Synthesis of GDP-mannose", "R-PFA-446205:r:Synthesis of GDP-mannose", "R-HSA-4043911:r:Defective PMM2 causes PMM2-CDG"], "type": "Family"}, "IPR005003": {"description": "Bacteriophage lambda, Tail fiber protein, repeat-1", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Phage_lambda_Stf-r1", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR005004": {"description": "Poxvirus C4/C10", "go_ids": [], "go_terms": [], "name": "Poxvirus_C4/C10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005005": {"description": "Poxvirus F12L", "go_ids": ["GO:0016032"], "go_terms": ["GO:0016032:viral process:P"], "name": "Poxvirus_F12L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005006": {"description": "Poxvirus J1", "go_ids": [], "go_terms": [], "name": "Poxvirus_J1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005007": {"description": "Poxvirus L3/FP4", "go_ids": [], "go_terms": [], "name": "Poxvirus_L3/FP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005008": {"description": "Poxvirus rifampicin-resistance", "go_ids": ["GO:0046677"], "go_terms": ["GO:0046677:response to antibiotic:P"], "name": "Poxvirus_Rif-R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005009": {"description": "Poxvirus mRNA capping enzyme, small subunit", "go_ids": ["GO:0004482", "GO:0006370"], "go_terms": ["GO:0004482:mRNA 5'-cap (guanine-N7-)-methyltransferase activity:F", "GO:0006370:7-methylguanosine mRNA capping:P"], "name": "Poxvirus_mRNA-cap_ssu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005010": {"description": "Rhabdovirus M1 matrix protein", "go_ids": [], "go_terms": [], "name": "Rhabdo_M1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005011": {"description": "SNU66/SART1 family", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "SNU66/SART1", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR005013": {"description": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit", "go_ids": ["GO:0005789", "GO:0006487"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0006487:protein N-linked 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degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Family"}, "IPR005015": {"description": "Thermostable direct haemolysin, vibrio", "go_ids": ["GO:0005576", "GO:0019836"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019836:symbiont-mediated hemolysis of host erythrocyte:P"], "name": "Thermostable_hemolysn_vibrio", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005016": {"description": "Serine incorporator/TMS membrane protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TDE1/TMS", "pathway_ids": ["R-DRE-977347", "R-DDI-977347", "R-MMU-977347", "R-RNO-977347", "R-SPO-977347", "R-SCE-977347", "R-HSA-977347", "R-BTA-977347"], "pathways": ["R-DRE-977347:r:Serine metabolism", "R-DDI-977347:r:Serine metabolism", "R-MMU-977347:r:Serine metabolism", "R-RNO-977347:r:Serine metabolism", "R-SPO-977347:r:Serine metabolism", "R-SCE-977347:r:Serine metabolism", "R-HSA-977347:r:Serine metabolism", "R-BTA-977347:r:Serine metabolism"], "type": "Family"}, "IPR005017": {"description": "Outer membrane protein transport protein (OMPP1/FadL/TodX)", "go_ids": [], "go_terms": [], "name": "OMPP1/FadL/TodX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005018": {"description": "DOMON domain", "go_ids": [], "go_terms": [], "name": "DOMON_domain", "pathway_ids": ["R-CFA-209905", "R-DME-209905", "R-HSA-209905", "R-RNO-209905", "R-MMU-209905"], "pathways": ["R-CFA-209905:r:Catecholamine biosynthesis", "R-DME-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-RNO-209905:r:Catecholamine biosynthesis", "R-MMU-209905:r:Catecholamine biosynthesis"], "type": "Domain"}, "IPR005019": {"description": "Methyladenine glycosylase", "go_ids": ["GO:0006284", "GO:0008725"], "go_terms": ["GO:0006284:base-excision repair:P", "GO:0008725:DNA-3-methyladenine glycosylase activity:F"], "name": "Adenine_glyco", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005020": {"description": "Protein LIN-8", "go_ids": [], "go_terms": [], "name": "LIN-8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005021": {"description": "Terminase large subunit-like", "go_ids": [], "go_terms": [], "name": "Terminase_largesu-like", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Family"}, "IPR005022": {"description": "Viral trans-activator protein", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Pox_TAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005023": {"description": "Viral late protein H2", "go_ids": [], "go_terms": [], "name": "Pox_LP_H2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005024": {"description": "Snf7 family", "go_ids": ["GO:0007034"], "go_terms": ["GO:0007034:vacuolar transport:P"], "name": "Snf7_fam", "pathway_ids": ["R-RNO-917729", "R-XTR-917729", "R-GGA-1632852", "R-MMU-917729", "R-MMU-9668328", "R-MMU-1632852", "R-HSA-5620971", "R-HSA-9668328", "R-GGA-5620971", "R-SPO-9668328", "R-RNO-1632852", "R-SCE-9668328", "R-BTA-5620971", "R-RNO-5620971", "R-XTR-1632852", "R-DRE-1632852", "R-BTA-9668328", "R-XTR-9668328", "R-SPO-1632852", "R-HSA-9615710", "R-DRE-9668328", "R-DDI-917729", "R-MMU-432720", "R-DME-917729", "R-HSA-9610379", "R-HSA-9694676", "R-DRE-917729", "R-DDI-1632852", "R-XTR-432720", "R-HSA-432720", "R-DME-9668328", "R-GGA-9668328", "R-SPO-917729", "R-HSA-162588", "R-SCE-917729", "R-BTA-1632852", "R-HSA-917729", "R-SCE-1632852", "R-HSA-1632852", "R-DME-1632852", "R-MMU-5620971", "R-GGA-917729", "R-BTA-917729", "R-HSA-9679504", "R-DDI-9668328", "R-RNO-9668328"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-XTR-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-GGA-1632852:r:Macroautophagy", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-1632852:r:Macroautophagy", "R-HSA-5620971:r:Pyroptosis", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-GGA-5620971:r:Pyroptosis", "R-SPO-9668328:r:Sealing of the nuclear envelope 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"R-XTR-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-GGA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SPO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-1632852:r:Macroautophagy", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SCE-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-MMU-5620971:r:Pyroptosis", "R-GGA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III"], "type": "Family"}, "IPR005025": {"description": "NADPH-dependent FMN reductase-like domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "FMN_Rdtase-like_dom", "pathway_ids": ["PWY-7999", "PWY-7731"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "PWY-7731:t:superpathway of photosynthetic hydrogen production"], "type": "Domain"}, "IPR005026": {"description": "SAPAP family", "go_ids": ["GO:0023052"], "go_terms": ["GO:0023052:signaling:P"], "name": "SAPAP", "pathway_ids": ["R-HSA-9013508", "R-RNO-6794361", "R-HSA-6794361", "R-MMU-6794361"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-RNO-6794361:r:Neurexins and neuroligins", "R-HSA-6794361:r:Neurexins and neuroligins", "R-MMU-6794361:r:Neurexins and neuroligins"], "type": "Family"}, "IPR005027": {"description": "Glycosyl transferase, family 43", "go_ids": ["GO:0015018", "GO:0016020"], "go_terms": ["GO:0015018:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity:F", "GO:0016020:membrane:C"], "name": "Glyco_trans_43", "pathway_ids": ["R-HSA-1971475", "R-CEL-1971475", "R-CFA-1971475", "R-MMU-1971475", "R-DME-1971475", "R-HSA-3560801"], "pathways": ["R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CFA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD"], "type": "Family"}, "IPR005028": {"description": "Herpesvirus intermediate/early protein 2/3, DNA-binding domain", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Herpes_IE2_3", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Domain"}, "IPR005029": {"description": "Herpesvirus UL47", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Herpes_UL47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005030": {"description": "Herpesvirus leader protein", "go_ids": [], "go_terms": [], "name": "Herpes_LP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005031": {"description": "Coenzyme Q-binding protein COQ10, START domain", "go_ids": [], "go_terms": [], "name": "COQ10_START", "pathway_ids": ["R-RNO-611105", "R-HSA-9864848", "R-HSA-611105", "R-DME-9864848", "R-DRE-611105", "R-MMU-611105", "R-DRE-9864848", "R-MMU-9864848", "R-DME-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-DME-9864848:r:Complex IV assembly", "R-DRE-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-DRE-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-DME-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR005033": {"description": "YEATS", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "YEATS", "pathway_ids": ["R-MMU-8866907", "R-MMU-9772755", "R-HSA-3214847", "R-HSA-8866907", "R-HSA-9772755"], "pathways": ["R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Family"}, "IPR005034": {"description": "Dicer, dimerisation domain", "go_ids": ["GO:0016891"], "go_terms": ["GO:0016891:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism:F"], "name": "Dicer_dimerisation", "pathway_ids": ["R-CEL-426486", "R-MMU-426486", "R-HSA-426486", "R-DME-203927", "R-MMU-203927", "R-HSA-9824594", "R-HSA-203927", "R-XTR-426486", "R-CEL-203927", "R-HSA-9820841", "R-HSA-9708296", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR005035": {"description": "Herpesvirus UL3", "go_ids": [], "go_terms": [], "name": "Herpes_UL3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005036": {"description": "CBM21 (carbohydrate binding type-21) domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "CBM21_dom", "pathway_ids": ["R-SCE-3322077", "R-HSA-3785653", "R-BTA-3322077", "R-MMU-3322077", "R-DRE-3322077", "R-DME-3322077", "R-RNO-3322077", "R-HSA-3322077"], "pathways": ["R-SCE-3322077:r:Glycogen synthesis", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-3322077:r:Glycogen synthesis", "R-MMU-3322077:r:Glycogen synthesis", "R-DRE-3322077:r:Glycogen synthesis", "R-DME-3322077:r:Glycogen synthesis", "R-RNO-3322077:r:Glycogen synthesis", "R-HSA-3322077:r:Glycogen synthesis"], "type": "Domain"}, "IPR005037": {"description": "Pre-mRNA-splicing factor 38", "go_ids": [], "go_terms": [], "name": "PRP38", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR005038": {"description": "Octapeptide repeat", "go_ids": ["GO:0019865"], "go_terms": ["GO:0019865:immunoglobulin binding:F"], "name": "Octapeptide", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR005039": {"description": "Antirepressor protein, C-terminal", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Ant_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005041": {"description": "Adenovirus E3B protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Adeno_E3B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005042": {"description": "TAL effector repeat", "go_ids": [], "go_terms": [], "name": "TAL_effector_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR005043": {"description": "Exportin-2, C-terminal", "go_ids": ["GO:0005515", "GO:0031267"], "go_terms": ["GO:0005515:protein binding:F", "GO:0031267:small GTPase binding:F"], "name": "XPO2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005044": {"description": "Protein of unknown function DUF282, Caenorhabditis species", "go_ids": [], "go_terms": [], "name": "DUF282_CAE_spp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005045": {"description": "CDC50/LEM3 family", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "CDC50/LEM3_fam", "pathway_ids": ["R-SCE-6798695", "R-MMU-6798695", "R-HSA-6798695", "R-BTA-6798695", "R-SPO-6798695", "R-GGA-6798695", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR005046": {"description": "Protein of unknown function DUF285", "go_ids": [], "go_terms": [], "name": "DUF285", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005047": {"description": "7TM GPCR, serpentine receptor class xa (Srxa)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Srxa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005048": {"description": "Domain of unknown function DUF287", "go_ids": [], "go_terms": [], "name": "DUF287", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005049": {"description": "STELLO-like", "go_ids": [], "go_terms": [], "name": "STL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005050": {"description": "Early nodulin 93 ENOD93 protein", "go_ids": [], "go_terms": [], "name": "Enod93", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005051": {"description": "Herpesvirus UL46", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Herpes_UL46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005052": {"description": "Legume-like lectin", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Lectin_leg", "pathway_ids": ["R-HSA-9013405", "R-MMU-204005", "R-RNO-5694530", "R-HSA-948021", "R-MMU-9013106", "R-MMU-5694530", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-HSA-9013106", "R-MMU-9013404", "R-RNO-204005", "R-HSA-5694530", "R-SCE-9013106", "R-HSA-9013404", "R-HSA-9013423", "R-HSA-204005", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-8980692", "R-BTA-5694530", "R-RNO-9013408", "R-BTA-204005", "R-HSA-9013408", "R-RNO-9013106", "R-RNO-9013404"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-948021:r:Transport to the Golgi and subsequent modification", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-5694530:r:Cargo concentration in the ER", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-5694530:r:Cargo concentration in the ER", "R-SCE-9013106:r:RHOC GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-BTA-5694530:r:Cargo concentration in the ER", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle"], "type": "Domain"}, "IPR005053": {"description": "MobA/MobL protein", "go_ids": [], "go_terms": [], "name": "MobA_MobL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005054": {"description": "Nepovirus coat protein", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Nepo_coat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005055": {"description": "4-Cysteine Soluble Protein", "go_ids": [], "go_terms": [], "name": "4CSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005056": {"description": "Matrix protein, N-terminal, pneumovirus", "go_ids": ["GO:0019031", "GO:0019068"], "go_terms": ["GO:0019031:viral envelope:C", "GO:0019068:virion assembly:P"], "name": "MATRX_N_pneumovirus", "pathway_ids": ["R-HSA-9828721", "R-HSA-9833110", "R-HSA-9828806", "R-HSA-9820962", "R-HSA-9820960"], "pathways": ["R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry"], "type": "Domain"}, "IPR005057": {"description": "Poxvirus E8", "go_ids": [], "go_terms": [], "name": "Poxvirus_E8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005058": {"description": "Poxvirus P4A", "go_ids": ["GO:0005198", "GO:0044423"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0044423:virion component:C"], "name": "Poxvirus_P4A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005059": {"description": "DNA-directed RNA polymerase, 35kDa subunit, poxviral", "go_ids": ["GO:0003677", "GO:0003899", "GO:0019083"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0019083:viral transcription:P"], "name": "DNA-dir_RNA_pol_35kDa_poxviral", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005060": {"description": "Rhabdovirus matrix protein", "go_ids": [], "go_terms": [], "name": "Rhabdo_matrix", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005061": {"description": "Vacuolar protein sorting-associated protein Ist1", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "Ist1", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-SPO-9668328", "R-SPO-6798695", "R-SCE-9668328", "R-MMU-9668328", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-9668328", "R-RNO-6798695", "R-DDI-9668328", "R-RNO-9668328"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SPO-6798695:r:Neutrophil degranulation", "R-SCE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III"], "type": "Family"}, "IPR005062": {"description": "SAC3/GANP/THP3, conserved domain", "go_ids": [], "go_terms": [], "name": "SAC3/GANP/THP3_conserved", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005063": {"description": "Transposase, IS1", "go_ids": ["GO:0003677", "GO:0004803", "GO:0006313"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004803:transposase activity:F", "GO:0006313:DNA transposition:P"], "name": "Transposase_27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005064": {"description": "Bordetella uptake gene", "go_ids": [], "go_terms": [], "name": "BUG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005066": {"description": "Moybdenum cofactor oxidoreductase, dimerisation", "go_ids": ["GO:0016491", "GO:0030151"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0030151:molybdenum ion binding:F"], "name": "MoCF_OxRdtse_dimer", "pathway_ids": ["R-MMU-1614517", "R-HSA-1614517", "R-DME-1614517", "R-RNO-1614517"], "pathways": ["R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-HSA-1614517:r:Sulfide oxidation to sulfate", "R-DME-1614517:r:Sulfide oxidation to sulfate", "R-RNO-1614517:r:Sulfide oxidation to sulfate"], "type": "Domain"}, "IPR005067": {"description": "Fatty acid desaturase, type 2", "go_ids": ["GO:0006631", "GO:0045300"], "go_terms": ["GO:0006631:fatty acid metabolic process:P", "GO:0045300:stearoyl-[ACP] desaturase activity:F"], "name": "Fatty_acid_desaturase-2", "pathway_ids": ["PWY-5147", "PWY-5366"], "pathways": ["PWY-5147:t:oleate biosynthesis I (plants)", "PWY-5366:t:palmitoleate biosynthesis II (plants and bacteria)"], "type": "Family"}, "IPR005068": {"description": "Bacteriophage lambda, Tail fiber protein, repeat-2", "go_ids": ["GO:0019062", "GO:0046718"], "go_terms": ["GO:0019062:virion attachment to host cell:P", "GO:0046718:symbiont entry into host cell:P"], "name": "Phage_lambda_Stf-r2", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR005069": {"description": "Nucleotide-diphospho-sugar transferase", "go_ids": [], "go_terms": [], "name": "Nucl-diP-sugar_transferase", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-DDI-983168", "R-DDI-69601", "R-DDI-8951664"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-8951664:r:Neddylation"], "type": "Domain"}, "IPR005070": {"description": "Foamy virus envelope protein", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Foamy_env", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005071": {"description": "Transmembrane glycoprotein", "go_ids": [], "go_terms": [], "name": "Glycoprotein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005072": {"description": "Peptidase M44, metalloendopeptidase G1", "go_ids": ["GO:0004222", "GO:0008270", "GO:0019058"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0008270:zinc ion binding:F", "GO:0019058:viral life cycle:P"], "name": "Peptidase_M44", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR005073": {"description": "Peptidase M74, penicillin-insensitive murein endopeptidase", "go_ids": ["GO:0004252", "GO:0006508", "GO:0030288"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0030288:outer membrane-bounded periplasmic space:C"], "name": "Peptidase_M74", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR005074": {"description": "Peptidase C39, bacteriocin processing", "go_ids": ["GO:0005524", "GO:0006508", "GO:0008233", "GO:0016020"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006508:proteolysis:P", "GO:0008233:peptidase activity:F", "GO:0016020:membrane:C"], "name": "Peptidase_C39", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR005076": {"description": "Glycosyl transferase, family 6", "go_ids": ["GO:0005975", "GO:0016020", "GO:0016758"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016020:membrane:C", "GO:0016758:hexosyltransferase activity:F"], "name": "Glyco_trans_6", "pathway_ids": ["R-MMU-9033807", "R-HSA-9033807", "R-RNO-9033807"], "pathways": ["R-MMU-9033807:r:ABO blood group biosynthesis", "R-HSA-9033807:r:ABO blood group biosynthesis", "R-RNO-9033807:r:ABO blood group biosynthesis"], "type": "Family"}, "IPR005077": {"description": "Peptidase C11, clostripain", "go_ids": [], "go_terms": [], "name": "Peptidase_C11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005078": {"description": "Peptidase C54", "go_ids": ["GO:0008234"], "go_terms": ["GO:0008234:cysteine-type peptidase activity:F"], "name": "Peptidase_C54", "pathway_ids": ["R-SCE-1632852", "R-CFA-1632852", "R-RNO-1632852", "R-DDI-1632852", "R-XTR-1632852", "R-SSC-1632852", "R-DRE-1632852", "R-CEL-1632852", "R-HSA-1632852", "R-MMU-1632852", "R-SPO-1632852", "R-BTA-1632852"], "pathways": ["R-SCE-1632852:r:Macroautophagy", "R-CFA-1632852:r:Macroautophagy", "R-RNO-1632852:r:Macroautophagy", "R-DDI-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-SSC-1632852:r:Macroautophagy", "R-DRE-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-BTA-1632852:r:Macroautophagy"], "type": "Family"}, "IPR005079": {"description": "Peptidase C45, hydrolase domain", "go_ids": [], "go_terms": [], "name": "Peptidase_C45_hydrolase", "pathway_ids": ["PWY-5630"], "pathways": ["PWY-5630:t:penicillin K biosynthesis"], "type": "Domain"}, "IPR005080": {"description": "Peptidase A25, germination protease", "go_ids": ["GO:0006508", "GO:0008233", "GO:0009847"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008233:peptidase activity:F", "GO:0009847:spore germination:P"], "name": "Peptidase_A25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005081": {"description": "Sigma-E processing peptidase SpoIIGA", "go_ids": ["GO:0004190", "GO:0006508", "GO:0030436"], "go_terms": ["GO:0004190:aspartic-type endopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0030436:asexual sporulation:P"], "name": "SpoIIGA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005082": {"description": "Prohead core protein protease", "go_ids": [], "go_terms": [], "name": "Prohead_core_protease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005083": {"description": "Serine/Threonine acetyltransferase YopJ-like", "go_ids": [], "go_terms": [], "name": "YopJ-like", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR005084": {"description": "Carbohydrate binding module family 6", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "CBM6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005085": {"description": "Carbohydrate binding module family 25", "go_ids": ["GO:2001070"], "go_terms": ["GO:2001070:starch binding:F"], "name": "CBM25", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005086": {"description": "Carbohydrate binding module family 17/28", "go_ids": ["GO:0008810", "GO:0030245"], "go_terms": ["GO:0008810:cellulase activity:F", "GO:0030245:cellulose catabolic process:P"], "name": "CBM17/28", "pathway_ids": ["PWY-6788"], "pathways": ["PWY-6788:t:cellulose degradation II (fungi)"], "type": "Domain"}, "IPR005087": {"description": "Carbohydrate binding module family 11", "go_ids": ["GO:0008810", "GO:0030245"], "go_terms": ["GO:0008810:cellulase activity:F", "GO:0030245:cellulose catabolic process:P"], "name": "CBM11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005088": {"description": "Carbohydrate binding module family 15", "go_ids": [], "go_terms": [], "name": "CBM15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005089": {"description": "Carbohydrate-binding module family 19", "go_ids": ["GO:0006032", "GO:0008061"], "go_terms": ["GO:0006032:chitin catabolic process:P", "GO:0008061:chitin binding:F"], "name": "CBM19", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-6855"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-6855:t:chitin degradation I (archaea)"], "type": "Domain"}, "IPR005090": {"description": "Plasmid replication protein C, N-terminal", "go_ids": [], "go_terms": [], "name": "RepC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005091": {"description": "Major surface protein 1B", "go_ids": [], "go_terms": [], "name": "MSP1b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005092": {"description": "Trans-activating transcriptional regulator", "go_ids": [], "go_terms": [], "name": "TATR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005093": {"description": "RNA-directed RNA polymerase beta-chain", "go_ids": ["GO:0003968", "GO:0039694"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0039694:viral RNA genome replication:P"], "name": "RNArep_beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005094": {"description": "MobA/VirD2-like, nuclease domain", "go_ids": [], "go_terms": [], "name": "Endonuclease_MobA/VirD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005095": {"description": "EspA-like type III filament-forming translocator protein", "go_ids": [], "go_terms": [], "name": "EspA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005096": {"description": "Protein of unknown function DUF276", "go_ids": [], "go_terms": [], "name": "DUF276", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005097": {"description": "Saccharopine dehydrogenase, NADP binding domain", "go_ids": [], "go_terms": [], "name": "Sacchrp_dh_NADP-bd", "pathway_ids": ["R-SCE-71064", "R-HSA-114608", "R-MMU-71064", "R-HSA-71064", "R-SPO-71064", "R-CEL-114608", "R-DDI-71064", "R-BTA-71064", "R-RNO-71064", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-SCE-71064:r:Lysine catabolism", "R-HSA-114608:r:Platelet degranulation", "R-MMU-71064:r:Lysine catabolism", "R-HSA-71064:r:Lysine catabolism", "R-SPO-71064:r:Lysine catabolism", "R-CEL-114608:r:Platelet degranulation", "R-DDI-71064:r:Lysine catabolism", "R-BTA-71064:r:Lysine catabolism", "R-RNO-71064:r:Lysine catabolism", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR005098": {"description": "Domain of unknown function DUF281", "go_ids": [], "go_terms": [], "name": "DUF281", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005099": {"description": "Pneumovirus NS1 protein", "go_ids": [], "go_terms": [], "name": "Pneumo_NS1", "pathway_ids": ["R-HSA-9828721", "R-HSA-9833109", "R-HSA-918233", "R-HSA-9833110", "R-HSA-9828806"], "pathways": ["R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9828806:r:Maturation of hRSV A proteins"], "type": "Family"}, "IPR005100": {"description": "NGN domain", "go_ids": [], "go_terms": [], "name": "NGN-domain", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-GGA-112382", "R-HSA-167238", "R-GGA-75955", "R-MMU-113418", "R-GGA-674695", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DME-77075", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-DRE-6807505", "R-DRE-77075", "R-HSA-167287", "R-DRE-75955", "R-HSA-167246", "R-DRE-6796648", "R-DME-72086", "R-DRE-113418", "R-HSA-167152", "R-HSA-113418", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-GGA-6796648", "R-SCE-6796648", "R-SPO-113418", "R-DME-113418", "R-SPO-77075", "R-CEL-75955", "R-MMU-6796648", "R-GGA-6807505", "R-DME-674695", "R-HSA-167243", "R-SCE-113418", "R-SCE-72086", "R-DRE-72086", "R-HSA-167242", "R-CEL-113418", "R-CEL-77075", "R-MMU-674695", "R-MMU-6807505", "R-CEL-674695", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-DRE-674695", "R-MMU-77075", "R-HSA-75955", "R-SCE-77075", "R-CEL-112382", "R-HSA-167160", "R-SCE-674695", "R-MMU-72086", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-GGA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-GGA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-72086:r:mRNA Capping", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-GGA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-72086:r:mRNA Capping", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR005101": {"description": "Cryptochrome/DNA photolyase, FAD-binding domain", "go_ids": [], "go_terms": [], "name": "Cryptochr/Photolyase_FAD-bd", "pathway_ids": ["R-HSA-9931510", "R-DME-432553", "R-DME-432395", "R-HSA-9931530", "R-HSA-9932298", "R-HSA-9931521", "R-DME-538864"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-432395:r:Degradation of TIM", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-DME-538864:r:Degradation of CRY"], "type": "Domain"}, "IPR005102": {"description": "Carbohydrate binding X2 domain", "go_ids": [], "go_terms": [], "name": "Carbo-bd_X2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005103": {"description": "Auxiliary Activity family 9, catalytic domain", "go_ids": [], "go_terms": [], "name": "AA9_LPMO", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005104": {"description": "Winged helix-turn-helix transcription repressor, HrcA DNA-binding domain", "go_ids": ["GO:0006355", "GO:0003677"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F"], "name": "WHTH_HrcA_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005105": {"description": "Protein-PII uridylyltransferase, N-terminal", "go_ids": ["GO:0008773"], "go_terms": ["GO:0008773:[protein-PII] uridylyltransferase activity:F"], "name": "GlnD_Uridyltrans_N", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I"], "type": "Domain"}, "IPR005106": {"description": "Aspartate/homoserine dehydrogenase, NAD-binding", "go_ids": ["GO:0016491", "GO:0050661"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0050661:NADP binding:F"], "name": "Asp/hSer_DH_NAD-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005107": {"description": "CO dehydrogenase flavoprotein, C-terminal", "go_ids": [], "go_terms": [], "name": "CO_DH_flav_C", "pathway_ids": ["R-MMU-9748787", "R-RNO-8851680", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", "R-RNO-74259", "R-GGA-421178", "R-DME-964975", "R-MMU-8851680", "R-HSA-9748787", "R-HSA-74259", "R-RNO-964975", "R-DME-74259", "R-MMU-964975", "R-DME-9748787", "R-MMU-74259", "R-DDI-964975", "R-RNO-9748787", "R-DDI-74259"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-GGA-421178:r:Urate synthesis", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-74259:r:Purine catabolism", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Domain"}, "IPR005108": {"description": "HELP motif", "go_ids": [], "go_terms": [], "name": "HELP", "pathway_ids": ["R-XTR-9648025", "R-DME-9648025", "R-HSA-9648025", "R-MMU-9648025", "R-HSA-9700645", "R-HSA-9725370"], "pathways": ["R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Conserved_site"}, "IPR005109": {"description": "Mannan polymerase complex subunit ANP1/MNN9/VAN1", "go_ids": [], "go_terms": [], "name": "ANP1/MNN9/VAN1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005110": {"description": "MoeA, N-terminal and linker domain", "go_ids": ["GO:0032324"], "go_terms": ["GO:0032324:molybdopterin cofactor biosynthetic process:P"], "name": "MoeA_linker/N", "pathway_ids": ["PWY-8171", "R-DME-947581", "R-RNO-947581", "R-DDI-947581", "R-HSA-947581", "R-MMU-947581"], "pathways": ["PWY-8171:t:molybdenum cofactor biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR005111": {"description": "MoeA, C-terminal, domain IV", "go_ids": ["GO:0032324"], "go_terms": ["GO:0032324:molybdopterin cofactor biosynthetic process:P"], "name": "MoeA_C_domain_IV", "pathway_ids": ["PWY-8171", "R-DME-947581", "R-RNO-947581", "R-DDI-947581", "R-HSA-947581", "R-MMU-947581"], "pathways": ["PWY-8171:t:molybdenum cofactor biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR005112": {"description": "dDENN domain", "go_ids": [], "go_terms": [], "name": "dDENN_dom", "pathway_ids": ["R-HSA-1483248", "R-HSA-5357905", "R-MMU-8876198", "R-CEL-8876198", "R-HSA-1660499", "R-DME-8876198", "R-MMU-5357905", "R-RNO-8876198", "R-RNO-5357905", "R-HSA-8876198", "R-SPO-8876198", "R-MMU-1483248", "R-CEL-1483248"], "pathways": ["R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane"], "type": "Domain"}, "IPR005113": {"description": "uDENN domain", "go_ids": [], "go_terms": [], "name": "uDENN_dom", "pathway_ids": ["R-HSA-1483248", "R-HSA-5357905", "R-MMU-8876198", "R-CEL-8876198", "R-HSA-1660499", "R-DME-8876198", "R-MMU-5357905", "R-RNO-8876198", "R-RNO-5357905", "R-HSA-8876198", "R-SPO-8876198", "R-MMU-1483248", "R-CEL-1483248"], "pathways": ["R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane"], "type": "Domain"}, "IPR005114": {"description": "Helicase-associated", "go_ids": [], "go_terms": [], "name": "Helicase_assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005115": {"description": "Glycine transporter", "go_ids": [], "go_terms": [], "name": "Gly_transporter", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005116": {"description": "Transport-associated OB, type 1", "go_ids": [], "go_terms": [], "name": "Transp-assoc_OB_typ1", "pathway_ids": ["PWY-8171"], "pathways": ["PWY-8171:t:molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR005117": {"description": "Nitrite/Sulfite reductase ferredoxin-like domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "NiRdtase/SiRdtase_haem-b_fer", "pathway_ids": ["PWY-6683", "R-MTU-936721"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Domain"}, "IPR005118": {"description": "Transcription-repair-coupling factor, C-terminal domain", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "TRCF_C", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR005119": {"description": "LysR, substrate-binding", "go_ids": [], "go_terms": [], "name": "LysR_subst-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005120": {"description": "UPF3 domain", "go_ids": [], "go_terms": [], "name": "UPF3_dom", "pathway_ids": ["R-DRE-159236", "R-DRE-72163", "R-HSA-72163", "R-HSA-975957", "R-DRE-73856", "R-SCE-975957", "R-SPO-159236", "R-HSA-9010553", "R-HSA-73856", "R-HSA-159236", "R-DRE-975957", "R-SPO-975957", "R-HSA-72187", "R-SPO-72163"], "pathways": ["R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR005121": {"description": "Ferrodoxin-fold anticodon-binding domain", "go_ids": [], "go_terms": [], "name": "Fdx_antiC-bd", "pathway_ids": ["R-HSA-379726"], "pathways": ["R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Domain"}, "IPR005122": {"description": "Uracil-DNA glycosylase-like", "go_ids": [], "go_terms": [], "name": "Uracil-DNA_glycosylase-like", "pathway_ids": ["R-SPO-3108214", "R-HSA-110357", "R-HSA-3108214", "R-HSA-110328", "R-MMU-5221030", "R-DDI-110329", "R-SCE-110329", "R-HSA-9609690", "R-RNO-110357", "R-BTA-110329", "R-BTA-110357", "R-HSA-9821002", "R-SPO-110329", "R-HSA-5221030", "R-HSA-110329", "R-MMU-110329", "R-MMU-3108214", "R-DDI-110357", "R-MMU-110357", "R-RNO-110329", "R-SPO-5221030"], "pathways": ["R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-MMU-5221030:r:TET1,2,3 and TDG demethylate DNA", "R-DDI-110329:r:Cleavage of the damaged pyrimidine", "R-SCE-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-BTA-110329:r:Cleavage of the damaged pyrimidine", "R-BTA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-SPO-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-5221030:r:TET1,2,3 and TDG demethylate DNA", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-RNO-110329:r:Cleavage of the damaged pyrimidine", "R-SPO-5221030:r:TET1,2,3 and TDG demethylate DNA"], "type": "Domain"}, "IPR005124": {"description": "Vacuolar (H+)-ATPase G subunit", "go_ids": ["GO:0046961", "GO:1902600", "GO:0016471"], "go_terms": ["GO:0046961:proton-transporting ATPase activity, rotational mechanism:F", "GO:1902600:proton transmembrane transport:P", "GO:0016471:vacuolar proton-transporting V-type ATPase complex:C"], "name": "V-ATPase_G", "pathway_ids": ["R-CEL-1222556", "R-MMU-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-HSA-9857377", "R-MMU-9639288", "R-XTR-77387", "R-SPO-9639288", "R-SSC-917977", "R-HSA-9639288", "R-XTR-1222556", "R-XTR-917977", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-XTR-983712", "R-SCE-1222556", "R-SCE-917977", "R-DDI-9639288", "R-BTA-1222556", "R-MMU-77387", "R-SCE-77387", "R-SSC-1222556", "R-SSC-77387", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-SSC-983712", "R-CEL-77387", "R-BTA-917977", "R-SSC-9639288", "R-HSA-983712", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-XTR-9639288", "R-SPO-77387", "R-CEL-917977", "R-HSA-917977", "R-DDI-917977", "R-DDI-983712", "R-MMU-983712", "R-BTA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-XTR-77387:r:Insulin receptor recycling", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-SSC-917977:r:Transferrin endocytosis and recycling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-XTR-1222556:r:ROS and RNS production in phagocytes", "R-XTR-917977:r:Transferrin endocytosis and recycling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-XTR-983712:r:Ion channel transport", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-77387:r:Insulin receptor recycling", "R-SCE-77387:r:Insulin receptor recycling", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-SSC-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-SSC-983712:r:Ion channel transport", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-SSC-9639288:r:Amino acids regulate mTORC1", "R-HSA-983712:r:Ion channel transport", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-DDI-983712:r:Ion channel transport", "R-MMU-983712:r:Ion channel transport", "R-BTA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR005126": {"description": "NapC/NirT cytochrome c, N-terminal", "go_ids": [], "go_terms": [], "name": "NapC/NirT_cyt_c_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005127": {"description": "Giardia variant-specific surface protein", "go_ids": [], "go_terms": [], "name": "Giardia_VSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005128": {"description": "Alpha-acetolactate decarboxylase", "go_ids": ["GO:0047605", "GO:0045151"], "go_terms": ["GO:0047605:acetolactate decarboxylase activity:F", "GO:0045151:acetoin biosynthetic process:P"], "name": "Acetolactate_a_deCO2ase", "pathway_ids": ["PWY-5939"], "pathways": ["PWY-5939:t:pyruvate fermentation to (R)-acetoin II"], "type": "Family"}, "IPR005129": {"description": "SIMIBI class G3E GTPase, ArgK/MeaB", "go_ids": ["GO:0003924", "GO:0005525"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005525:GTP binding:F"], "name": "GTPase_ArgK", "pathway_ids": ["R-HSA-3359478", "R-CEL-71032", "R-CEL-9759218", "R-HSA-71032", "R-MMU-9759218", "R-HSA-3359475", "R-HSA-9759218", "R-MMU-71032"], "pathways": ["R-HSA-3359478:r:Defective MUT causes MMAM", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-3359475:r:Defective MMAA causes MMA, cblA type", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-71032:r:Propionyl-CoA catabolism"], "type": "Family"}, "IPR005130": {"description": "Serine dehydratase-like, alpha subunit", "go_ids": [], "go_terms": [], "name": "Ser_deHydtase-like_asu", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005131": {"description": "Serine dehydratase beta chain", "go_ids": ["GO:0003941", "GO:0006094", "GO:0051539"], "go_terms": ["GO:0003941:L-serine ammonia-lyase activity:F", "GO:0006094:gluconeogenesis:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Ser_deHydtase_bsu", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005133": {"description": "Na+/H+ antiporter subunit G", "go_ids": ["GO:0015297", "GO:0055085"], "go_terms": ["GO:0015297:antiporter activity:F", "GO:0055085:transmembrane transport:P"], "name": "PhaG_MnhG_YufB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005134": {"description": "Uncharacterised protein family UPF0114", "go_ids": [], "go_terms": [], "name": "UPF0114", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005135": {"description": "Endonuclease/exonuclease/phosphatase", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Endo/exonuclease/phosphatase", "pathway_ids": ["R-DDI-9840310", "R-MMU-9840310", "R-RNO-9840310", "R-HSA-6798695", "R-HSA-6804115", "R-HSA-110357", "R-HSA-5626978", "R-MMU-5693571", "R-DRE-110373", "R-RNO-110362", "R-DME-110357", "R-DME-9840310", "R-DRE-110362", "R-HSA-1368108", "R-RNO-6804115", "R-MMU-6798695", "R-DRE-5693571", "R-MMU-110362", "R-MMU-429947", "R-RNO-5626978", "R-HSA-73933", "R-RNO-73933", "R-MMU-5626978", "R-BTA-8983711", "R-HSA-9029569", "R-SCE-9840310", "R-MMU-110357", "R-MMU-8983711", "R-MMU-73933", "R-HSA-110373", "R-DDI-110362", "R-HSA-8983711", "R-DME-5651801", "R-HSA-5617472", "R-RNO-8983711", "R-DRE-110357", "R-HSA-9840310", "R-MMU-5651801", "R-PFA-110373", "R-HSA-429947", "R-HSA-110362", "R-DDI-73930", "R-RNO-110357", "R-HSA-5651801", "R-RNO-5693571", "R-DDI-73933", "R-DME-110373", "R-DRE-73933", "R-HSA-193681", "R-HSA-5693571", "R-MMU-110373", "R-RNO-73930", "R-CEL-9840310", "R-PFA-73933", "R-MMU-73930", "R-RNO-5651801", "R-HSA-9820841", "R-DRE-5651801", "R-BTA-5693571", "R-DRE-73930", "R-SPO-9840310", "R-DDI-110373", "R-HSA-73930", "R-DME-73933", "R-DDI-110357", "R-RNO-110373", "R-DRE-6804115", "R-MMU-6804115", "R-RNO-6798695", "R-PFA-110357"], "pathways": ["R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-110357:r:Displacement of DNA glycosylase by APEX1", "R-DME-9840310:r:Glycosphingolipid catabolism", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-429947:r:Deadenylation of mRNA", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-HSA-73933:r:Resolution of Abasic Sites (AP sites)", "R-RNO-73933:r:Resolution of Abasic Sites (AP sites)", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-BTA-8983711:r:OAS antiviral response", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-SCE-9840310:r:Glycosphingolipid catabolism", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-8983711:r:OAS antiviral response", "R-MMU-73933:r:Resolution of Abasic Sites (AP sites)", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DDI-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-8983711:r:OAS antiviral response", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain 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pathway", "R-DME-73933:r:Resolution of Abasic Sites (AP sites)", "R-DDI-110357:r:Displacement of DNA glycosylase by APEX1", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-RNO-6798695:r:Neutrophil degranulation", "R-PFA-110357:r:Displacement of DNA glycosylase by APEX1"], "type": "Domain"}, "IPR005137": {"description": "Membrane complex biogenesis protein, BtpA family", "go_ids": [], "go_terms": [], "name": "BtpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005138": {"description": "Aerolysin/Pertussis toxin domain", "go_ids": [], "go_terms": [], "name": "APT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005139": {"description": "Peptide chain release factor", "go_ids": ["GO:0006415"], "go_terms": ["GO:0006415:translational termination:P"], "name": "PCRF", "pathway_ids": ["R-MMU-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-HSA-5419276", "R-RNO-5419276"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination"], "type": "Domain"}, "IPR005140": {"description": "eRF1/Pelota-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "eRF1_Pelota-like_N", "pathway_ids": ["R-RNO-9629569", "R-DDI-975956", "R-BTA-975957", "R-CEL-975957", "R-SPO-72764", "R-HSA-9010553", "R-SPO-9954714", "R-CEL-9629569", "R-XTR-975956", "R-SPO-975957", "R-CEL-72764", "R-HSA-975956", "R-XTR-975957", "R-CEL-975956", "R-DME-72764", "R-SCE-975957", "R-BTA-72764", "R-CEL-9954714", "R-SCE-72764", "R-MMU-975956", 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"R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "type": "Domain"}, "IPR005143": {"description": "Transcription factor LuxR-like, autoinducer-binding domain", "go_ids": [], "go_terms": [], "name": "TF_LuxR_autoind-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005144": {"description": "ATP-cone domain", "go_ids": [], "go_terms": [], "name": "ATP-cone_dom", "pathway_ids": ["R-DRE-499943", "R-DME-499943", "R-HSA-499943", "R-MMU-499943", "R-CEL-499943"], "pathways": ["R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide 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regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Domain"}, "IPR005149": {"description": "Transcription regulator PadR, N-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_PadR_N", "pathway_ids": ["R-HSA-9638334"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin"], "type": "Domain"}, "IPR005150": {"description": "Cellulose synthase", "go_ids": ["GO:0016020", "GO:0016760", "GO:0030244"], "go_terms": ["GO:0016020:membrane:C", "GO:0016760:cellulose synthase (UDP-forming) activity:F", "GO:0030244:cellulose biosynthetic process:P"], "name": "Cellulose_synth", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005151": {"description": "Tail specific 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"pathways": [], "type": "Family"}, "IPR005217": {"description": "Iron permease EfeU/FTR1-like", "go_ids": ["GO:0034755", "GO:0005381", "GO:0033573", "GO:0005886"], "go_terms": ["GO:0034755:iron ion transmembrane transport:P", "GO:0005381:iron ion transmembrane transporter activity:F", "GO:0033573:high-affinity iron permease complex:C", "GO:0005886:plasma membrane:C"], "name": "EfeU/FTR1-like", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR005218": {"description": "Diacylglycerol/lipid kinase", "go_ids": ["GO:0016301", "GO:0008654", "GO:0005524", "GO:0016310"], "go_terms": ["GO:0016301:kinase activity:F", "GO:0008654:phospholipid biosynthetic process:P", "GO:0005524:ATP binding:F", "GO:0016310:phosphorylation:P"], "name": "Diacylglycerol/lipid_kinase", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR005219": {"description": "Intermembrane transport protein PqiA-like, proteobacteria", "go_ids": [], "go_terms": [], "name": "PqiA-like_proteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005220": {"description": "Calcium-regulated OB-fold protein CarO-like", "go_ids": [], "go_terms": [], "name": "CarO-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005222": {"description": "Competence protein ComF", "go_ids": [], "go_terms": [], "name": "Competence_ComF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005224": {"description": "Sugar fermentation stimulation protein", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "SfsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005225": {"description": "Small GTP-binding domain", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "Small_GTP-bd", "pathway_ids": ["R-DME-5389840", "R-CEL-6811558", "R-MMU-354192", "R-GGA-5673000", "R-GGA-9013424", "R-SCE-72706", "R-SCE-381676", "R-BTA-983231", "R-SPO-5625740", "R-MMU-8964616", "R-GGA-5627123", "R-BTA-416572", "R-RNO-416482", "R-RNO-389359", "R-MMU-2132295", "R-GGA-6811440", "R-RNO-3928662", "R-DRE-5625970", "R-BTA-8876198", "R-CFA-5666185", "R-DME-6811440", "R-HSA-5655332", "R-DME-5654719", "R-DRE-179812", "R-RNO-5626467", "R-BTA-6811440", "R-CEL-380972", "R-DDI-5675221", "R-DME-6811434", "R-RNO-9032759", "R-DRE-4420097", "R-HSA-180746", "R-CEL-114604", "R-DRE-5674135", "R-CEL-8980692", "R-HSA-5689896", "R-HSA-8856828", "R-SSC-9013408", "R-RNO-416572", "R-MMU-2565942", "R-CEL-5673001", "R-HSA-5694530", "R-HSA-9013425", "R-DME-210993", "R-DRE-6798695", "R-RNO-170968", "R-MMU-399954", "R-DRE-5666185", "R-HSA-9673767", "R-GGA-3928662", "R-RNO-9748787", "R-DME-5673000", "R-SCE-199992", "R-GGA-8856828", "R-CEL-525793", "R-MMU-1433557", "R-MMU-5620916", "R-GGA-9013148", "R-MMU-5621575", "R-RNO-432720", "R-DRE-5620922", "R-CEL-5628897", "R-SSC-9013406", "R-HSA-8876198", "R-RNO-5578749", "R-CFA-209563", "R-MMU-8876198", "R-MMU-9013406", "R-SCE-2029482", "R-SCE-445144", "R-RNO-9639288", "R-MMU-6798695", "R-CEL-186763", "R-BTA-354192", "R-SCE-5620916", "R-SSC-9013148", "R-DRE-8851805", "R-MMU-114608", "R-SSC-5654699", "R-HSA-416550", "R-RNO-9674555", "R-CEL-392451", "R-CFA-8873719", "R-DDI-1660499", "R-DDI-9615933", "R-MMU-6807878", "R-PFA-199992", "R-RNO-2029482", "R-GGA-186763", "R-RNO-5668599", "R-BTA-5674135", "R-CEL-5654706", "R-HSA-1222556", "R-SPO-5620916", "R-HSA-1169092", "R-DME-166208", "R-DRE-5675221", "R-DME-9013406", "R-CFA-193634", "R-SSC-2029482", "R-CEL-181429", "R-DME-1250347", "R-DDI-156902", "R-HSA-432722", "R-HSA-380972", "R-DME-170968", "R-SCE-6807878", "R-HSA-83936", "R-HSA-2173791", "R-HSA-5654706", "R-SSC-210500", "R-GGA-5663213", "R-SPO-8876725", "R-HSA-1660514", "R-HSA-9824585", "R-HSA-888590", "R-HSA-3928663", "R-HSA-5627123", "R-CEL-4420097", "R-HSA-9845576", "R-MMU-416482", "R-CEL-8849471", "R-MMU-5419276", "R-HSA-9664422", "R-SSC-8875656", "R-DDI-1169092", "R-CFA-416482", "R-DDI-156842", "R-CEL-5218920", "R-SSC-204005", "R-CEL-199992", "R-HSA-5689880", "R-MMU-9013408", "R-MMU-210993", "R-HSA-9639288", "R-MMU-8854214", "R-CEL-888590", "R-GGA-5654706", "R-MMU-5663213", "R-BTA-5663213", "R-MMU-9013420", "R-RNO-983231", "R-MMU-1655829", "R-GGA-5658442", "R-GGA-9615933", "R-SSC-5654706", "R-MMU-5673001", "R-DRE-5358493", "R-RNO-5673000", "R-BTA-5625740", "R-HSA-181430", "R-CFA-9013406", "R-HSA-182971", "R-CFA-8980692", "R-MMU-5624958", "R-BTA-182971", "R-HSA-2424491", "R-MMU-72163", "R-PFA-6811438", "R-RNO-5628897", "R-DDI-3371511", "R-HSA-5637810", "R-GGA-5674135", "R-DME-9615933", "R-HSA-9615933", "R-DME-8951936", "R-SPO-5627123", "R-DME-162658", "R-RNO-9696264", "R-DME-1632852", "R-HSA-445144", "R-MMU-5627123", "R-BTA-83936", "R-GGA-5578749", "R-MMU-5675221", "R-MMU-416550", "R-HSA-8857538", "R-DME-5358493", "R-SCE-8876725", "R-HSA-5625900", "R-HSA-416572", "R-DME-432720", "R-MMU-380972", "R-MMU-8980692", "R-CEL-432720", "R-CEL-983170", "R-SCE-162658", "R-DME-1433557", "R-HSA-9013423", "R-DME-392517", "R-DRE-9937383", "R-HSA-203927", "R-CFA-6811558", "R-CEL-354192", "R-HSA-1250196", "R-SPO-9013420", "R-SPO-198203", "R-MMU-3928664", "R-BTA-8856828", "R-DDI-1632852", "R-GGA-9634635", "R-SSC-432040", "R-MMU-212676", "R-SCE-9696264", "R-DDI-9629569", "R-SPO-1660514", "R-DDI-166208", "R-SCE-8876198", "R-HSA-9726842", "R-MMU-1660499", "R-MMU-8943724", "R-GGA-5654712", "R-GGA-1250347", "R-SCE-392451", "R-CEL-198203", "R-DME-5419276", "R-HSA-8875656", "R-DME-5654706", "R-RNO-5627123", "R-DDI-354192", "R-CFA-4086400", "R-MMU-6785631", "R-BTA-9013424", "R-DME-8964616", "R-DME-4086400", "R-HSA-8849471", "R-BTA-3928663", "R-SPO-9013106", "R-DME-2424491", "R-SSC-5663213", "R-RNO-5419276", "R-HSA-9649948", "R-GGA-5687128", "R-RNO-5624138", "R-SCE-9013420", "R-MMU-1660514", "R-RNO-9013406", "R-CFA-5627117", "R-DDI-1660517", "R-CEL-6785631", "R-CEL-9013148", "R-HSA-5655302", "R-XTR-392517", "R-MMU-193634", "R-MMU-5620924", "R-DDI-193648", "R-MMU-9748787", "R-RNO-5654693", "R-SCE-198203", "R-DME-9629569", "R-HSA-8950505", "R-MMU-5654700", "R-DME-2173791", "R-MMU-6811436", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-5658442", "R-MMU-5358493", "R-DME-181430", "R-HSA-9613829", "R-MMU-5620922", "R-DRE-416482", "R-HSA-5654704", "R-MMU-5389840", "R-SCE-392517", "R-DME-5625900", "R-CEL-375165", "R-CFA-5218920", "R-RNO-8943724", "R-SPO-5687128", "R-CEL-1632852", "R-SCE-8873719", "R-DME-350368", "R-CFA-9013404", "R-CEL-418885", "R-HSA-1236382", "R-RNO-9845576", "R-SPO-9013409", "R-HSA-9619229", "R-DME-181429", "R-HSA-9029569", "R-HSA-5620912", "R-CFA-983231", "R-BTA-1655829", "R-HSA-9028731", "R-DRE-5419276", "R-HSA-354192", "R-MMU-5666185", "R-GGA-2871796", "R-HSA-193648", "R-RNO-1963640", "R-BTA-2173791", "R-HSA-8964616", "R-RNO-9634635", "R-CEL-6811436", "R-HSA-354194", "R-CEL-8876725", "R-MMU-181429", "R-CFA-9013420", "R-DME-212676", "R-RNO-204005", "R-MMU-156902", "R-CEL-2029482", "R-DRE-8876725", "R-HSA-5687128", "R-RNO-8873719", "R-DME-198203", "R-MMU-166208", "R-MMU-2424491", "R-CEL-1660499", "R-DRE-5654688", "R-DDI-72706", "R-DME-4420097", "R-CFA-193648", "R-HSA-9013405", "R-DDI-983170", "R-SPO-416482", "R-DRE-5654699", "R-RNO-5625970", "R-MMU-180336", "R-MMU-8963888", "R-DDI-8873719", "R-BTA-3928662", "R-MMU-1632852", "R-DRE-1250347", "R-CFA-3928665", "R-HSA-9027284", "R-BTA-5358493", "R-DRE-156902", "R-DDI-210500", "R-MMU-5689880", "R-SSC-2132295", "R-HSA-432040", "R-HSA-5368286", "R-CEL-182971", "R-CEL-1169092", "R-DME-5663213", "R-RNO-165159", "R-GGA-5673001", "R-DME-9607240", "R-DDI-204005", "R-MMU-9013407", "R-MMU-170968", "R-HSA-5624958", "R-RNO-9824585", "R-BTA-381676", "R-DRE-1169092", "R-DDI-5673001", "R-DRE-186763", "R-PFA-9845576", "R-DDI-6811438", "R-BTA-416550", "R-MMU-171007", "R-HSA-399954", "R-DRE-8854214", "R-BTA-6785631", "R-DRE-8980692", "R-RNO-5621575", "R-DME-165159", "R-DRE-198203", "R-HSA-179812", "R-SCE-983231", "R-RNO-9013420", "R-RNO-2871796", "R-BTA-1660499", "R-SSC-6798695", "R-DME-432553", "R-CEL-5687128", "R-SPO-9615933", "R-SSC-5626467", "R-CFA-5625740", "R-RNO-166208", "R-SCE-3928662", "R-HSA-166208", "R-RNO-2565942", "R-BTA-8985586", "R-DDI-8876198", "R-MMU-5654704", "R-GGA-9013408", "R-RNO-8856828", "R-GGA-9013149", "R-DDI-9639288", "R-CEL-5389840", "R-SSC-5654712", "R-DME-6798695", "R-DME-2179392", "R-BTA-432720", "R-GGA-392517", "R-MMU-9013424", "R-MMU-210500", "R-GGA-5654704", "R-RNO-3928664", "R-CFA-5620912", "R-SSC-5654693", "R-DRE-2173791", "R-HSA-983170", "R-DDI-162658", "R-BTA-6811438", "R-BTA-209563", "R-MMU-1222556", "R-SSC-5663220", "R-CEL-5626467", "R-SCE-1660514", "R-CEL-6798695", "R-BTA-199992", "R-BTA-6798695", "R-HSA-9670439", "R-DME-380972", "R-DME-2029482", "R-MMU-445989", "R-MMU-5627117", "R-MMU-392451", "R-CEL-5654700", "R-CEL-8964616", "R-CEL-204005", "R-RNO-9013404", "R-HSA-9013408", "R-CEL-3928662", "R-CEL-5666185", "R-CEL-8854214", "R-GGA-445989", "R-DME-5674135", "R-HSA-3928664", "R-SPO-72706", "R-BTA-9648002", "R-CFA-9032759", "R-RNO-3928663", "R-HSA-264642", "R-SPO-5694530", "R-SSC-5654719", "R-GGA-9013423", "R-CEL-5627117", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-RNO-2173791", "R-HSA-204005", "R-DME-2871796", "R-CFA-399954", "R-DME-1655829", "R-DDI-5627123", "R-SSC-389359", "R-DRE-8875656", "R-HSA-1257604", "R-SCE-5687128", "R-DRE-5627117", "R-DME-8943724", "R-DRE-1660499", "R-SPO-6798695", "R-HSA-2132295", "R-RNO-983170", "R-MMU-9937383", "R-MMU-9648002", "R-HSA-74751", "R-DME-5654693", "R-DME-525793", "R-BTA-5663220", "R-HSA-6787450", "R-HSA-1250347", "R-MMU-83936", "R-BTA-5627123", "R-MMU-198203", "R-RNO-5663213", "R-HSA-9673770", "R-HSA-9636383", "R-DRE-8849471", "R-MMU-9824585", "R-HSA-9035034", "R-CFA-5620916", "R-DME-9013409", "R-SPO-8873719", "R-DDI-6811440", "R-CEL-6811438", "R-SCE-9013424", "R-HSA-8851805", "R-MMU-5218921", "R-SSC-2871796", "R-BTA-9013420", "R-RNO-5654706", "R-SSC-179812", "R-BTA-5620922", "R-HSA-9706019", "R-CEL-5620912", "R-DME-8876198", "R-SSC-5654704", "R-SSC-2424491", "R-SPO-9035034", "R-HSA-9673324", "R-MMU-2029482", "R-CFA-5625900", "R-SSC-5673001", "R-DDI-8943724", "R-SCE-165159", "R-SSC-8856828", "R-RNO-2424491", "R-HSA-165159", "R-BTA-8854214", "R-RNO-5654700", "R-HSA-5663213", "R-SSC-5673000", "R-RNO-83936", "R-BTA-9696273", "R-MMU-114604", "R-RNO-9607240", "R-CEL-5673000", "R-CEL-5621575", "R-DME-9634635", "R-MMU-9615933", "R-BTA-525793", "R-HSA-6811434", "R-MMU-8851805", "R-RNO-6811558", "R-CEL-165159", "R-DME-3928664", "R-SPO-389359", "R-GGA-9013420", "R-GGA-8875555", "R-SSC-8963888", "R-RNO-156902", "R-MMU-5578749", "R-CEL-5694530", "R-CFA-392451", "R-CFA-4420097", "R-MMU-4086400", "R-CEL-6807878", "R-SSC-181429", "R-RNO-209563", "R-DME-5675221", "R-MMU-9013423", "R-HSA-5654699", "R-RNO-8875656", "R-RNO-8851805", "R-CFA-8875656", "R-BTA-156902", "R-MMU-983170", "R-CFA-198203", "R-DRE-8985586", "R-HSA-9648002", "R-SSC-1433557", "R-RNO-6798695", "R-HSA-9768919", "R-HSA-9656223", "R-HSA-5620922", "R-BTA-2029482", "R-CFA-8985586", "R-CFA-2871796", "R-HSA-9705671", "R-MMU-5654699", "R-DME-5578749", "R-BTA-8964616", "R-SPO-9013406", "R-HSA-181429", "R-HSA-5620916", "R-DDI-9706019", "R-HSA-5336415", "R-HSA-72165", "R-SSC-9634635", "R-DME-5654699", "R-RNO-5389840", "R-CEL-9013423", "R-SCE-9013409", "R-DDI-2029482", "R-HSA-1963640", "R-RNO-5694530", "R-CFA-8856828", "R-SSC-5620916", "R-RNO-181430", "R-DDI-5663213", "R-DME-432722", "R-SPO-6811440", "R-HSA-8963888", "R-SCE-9013106", "R-MMU-8873719", "R-CFA-6811434", "R-RNO-1660499", "R-MMU-72165", "R-BTA-9013404", "R-CEL-8873719", "R-SCE-6811438", "R-SSC-983231", "R-CEL-9013420", "R-BTA-1257604", "R-BTA-5419276", "R-CFA-6798695", "R-MMU-9013149", "R-GGA-372708", "R-CEL-983231", "R-MMU-182971", "R-HSA-5674135", "R-CFA-2424491", "R-DME-375165", "R-GGA-8849471", "R-DME-5621575", "R-CFA-162658", "R-DME-114604", "R-DRE-5654712", "R-CEL-9013424", "R-HSA-2179392", "R-GGA-354194", "R-HSA-9013424", "R-DDI-5626467", "R-DME-350376", "R-MMU-2871796", "R-GGA-8875656", "R-MMU-9013422", "R-RNO-2179392", "R-SPO-9696273", "R-CFA-9013408", "R-DRE-1963640", "R-SSC-180336", "R-HSA-164944", "R-BTA-392517", "R-DME-5663220", "R-HSA-9664565", "R-CEL-264642", "R-BTA-8876725", "R-DRE-5654706", "R-SPO-9696264", "R-DME-210500", "R-XTR-8875555", "R-HSA-5624138", "R-SSC-525793", "R-BTA-888590", "R-BTA-9937383", "R-DRE-210993", "R-RNO-418885", "R-HSA-9013404", "R-SCE-9013148", "R-DME-445144", "R-SPO-6811438", "R-HSA-9703648", "R-CEL-5627123", "R-RNO-264642", "R-RNO-380972", "R-DME-1963640", "R-HSA-372708", "R-DME-5628897", "R-SPO-5620912", "R-SSC-9696264", "R-RNO-6785631", "R-MMU-432722", "R-HSA-418885", "R-RNO-354194", "R-DME-888590", "R-MMU-372708", "R-HSA-168333", "R-BTA-114608", "R-CFA-5668599", "R-CEL-5625740", "R-MMU-9013425", "R-MMU-432720", "R-DRE-5654693", "R-HSA-9918481", "R-SSC-8849471", "R-DME-350407", "R-BTA-5689896", "R-GGA-5654699", "R-HSA-4086400", "R-HSA-156902", "R-MMU-8985586", "R-HSA-1433557", "R-MMU-209563", "R-CEL-381676", "R-HSA-1810476", "R-HSA-9703465", "R-HSA-428543", "R-GGA-8964616", "R-BTA-432722", "R-GGA-182971", "R-DRE-5654719", "R-MMU-9696270", "R-HSA-5675221", "R-MMU-8856828", "R-HSA-9646399", "R-BTA-198203", "R-SSC-9607240", "R-SCE-204005", "R-GGA-1655829", "R-GGA-5675221", "R-CEL-9607240", "R-DRE-5624138", "R-MMU-199992", "R-CEL-4086398", "R-MMU-8849471", "R-BTA-354194", "R-RNO-193648", "R-HSA-170984", "R-MMU-9035034", "R-SPO-2029482", "R-RNO-4086400", "R-SPO-8854214", "R-MMU-392517", "R-MMU-5625900", "R-HSA-432720", "R-MMU-5673000", "R-HSA-72706", "R-RNO-9013148", "R-RNO-5663220", "R-DRE-5673000", "R-CFA-9013407", "R-DRE-1655829", "R-DME-5218920", "R-DDI-5674135", "R-CEL-9937383", "R-DME-193648", "R-DRE-9013026", "R-MMU-5654712", "R-MMU-9696264", "R-RNO-5654712", "R-HSA-392517", "R-HSA-9680350", "R-SSC-375165", "R-DME-180336", "R-DRE-3928662", "R-RNO-8980692", "R-RNO-1257604", "R-HSA-5625740", "R-BTA-5578749", "R-DDI-6811434", "R-CEL-2179392", "R-DDI-9013422", "R-GGA-5625970", "R-RNO-5654719", "R-SCE-5626467", "R-CEL-1655829", "R-CEL-9748787", "R-CEL-5654712", "R-CEL-9013406", "R-CEL-5620916", "R-CEL-171007", "R-RNO-8985586", "R-SSC-8876198", "R-DME-199992", "R-GGA-1433557", "R-GGA-5218921", "R-CFA-1433557", "R-SCE-983170", "R-RNO-5627117", "R-HSA-1912420", "R-SPO-199992", "R-DRE-9646399", "R-HSA-5666185", "R-GGA-5654700", "R-RNO-210500", "R-HSA-6785631", "R-HSA-9034864", "R-MMU-354194", "R-MMU-1257604", "R-DDI-9648002", "R-MMU-9629569", "R-SCE-9696270", "R-DRE-375165", "R-HSA-170968", "R-HSA-428540", "R-SCE-389359", "R-RNO-432040", "R-RNO-72706", "R-MMU-1963640", "R-SCE-9615933", "R-BTA-8873719", "R-MMU-9013106", "R-MMU-5694530", "R-SCE-416482", "R-CEL-432722", "R-MMU-5625740", "R-SSC-1250347", "R-HSA-9026519", "R-MMU-416572", "R-MMU-381676", "R-DRE-5673001", "R-CFA-1257604", "R-MMU-72706", "R-DDI-170968", "R-SSC-210993", "R-BTA-389359", "R-SCE-5694530", "R-GGA-5654693", "R-RNO-162658", "R-MMU-162658", "R-BTA-5620912", "R-RNO-3928665", "R-HSA-8943724", "R-DME-3928665", "R-DDI-9013423", "R-RNO-9013408", "R-BTA-204005", "R-DME-6807878", "R-RNO-5673001", "R-HSA-8951936", "R-RNO-179812", "R-DME-5654704", "R-SCE-6811434", "R-HSA-210993", "R-RNO-5620916", "R-BTA-5687128", "R-RNO-6811438", "R-DME-3928662", "R-HSA-2029482", "R-DRE-354192", "R-HSA-5218921", "R-SPO-8980692", "R-DME-171007", "R-BTA-5668599", "R-BTA-9615933", "R-DRE-5654704", "R-CEL-1963640", "R-DRE-354194", "R-GGA-179812", "R-CEL-5689896", "R-DDI-8866654", "R-BTA-210500", "R-HSA-167044", "R-DME-5654700", "R-DDI-199992", "R-DME-9013424", "R-MMU-983231", "R-HSA-1660499", "R-HSA-375165", "R-HSA-6811440", "R-DME-264642", "R-RNO-1660514", "R-BTA-5389840", "R-SSC-5625970", "R-HSA-5621575", "R-DME-983231", "R-CEL-5654699", "R-DME-9748787", "R-HSA-525793", "R-DME-450728", "R-BTA-392451", "R-CEL-5675221", "R-MMU-888590", "R-SSC-9013423", "R-DDI-1660516", "R-HSA-9937383", "R-RNO-381676", "R-SSC-9824585", "R-RNO-4086398", "R-DRE-9615933", "R-MMU-8875656", "R-RNO-182971", "R-DDI-5358493", "R-HSA-392451", "R-MMU-418885", "R-HSA-9013409", "R-GGA-8854214", "R-DRE-9648002", "R-MMU-9674555", "R-MMU-5624138", "R-MMU-4086398", "R-CFA-8964616", "R-DME-5218921", "R-BTA-8963888", "R-HSA-442982", "R-SSC-5687128", "R-HSA-5673000", "R-HSA-5218920", "R-GGA-9013404", "R-DDI-5673000", "R-DRE-5663220", "R-MMU-5620912", "R-BTA-8875656", "R-DDI-445144", "R-HSA-210500", "R-SPO-5626467", "R-SPO-392451", "R-BTA-181430", "R-SSC-5654700", "R-RNO-210993", "R-RNO-445144", "R-DME-9845576", "R-HSA-416482", "R-CFA-445144", "R-SSC-114604", "R-SPO-9013148", "R-CEL-9648002", "R-HSA-9696264", "R-DME-8876725", "R-RNO-6811436", "R-RNO-5654688", "R-BTA-170984", "R-SSC-983170", "R-HSA-1445148", "R-MMU-193648", "R-HSA-9013026", "R-DME-182971", "R-CEL-170968", "R-HSA-212676", "R-DRE-9013419", "R-HSA-5655253", "R-HSA-6811438", "R-DME-5673001", "R-SSC-8964616", "R-HSA-8854214", "R-SSC-9013404", "R-DDI-165159", "R-GGA-162658", "R-SCE-6798695", "R-GGA-114604", "R-CFA-9035034", "R-BTA-9013406", "R-HSA-9013106", "R-HSA-2428933", "R-CFA-5663213", "R-GGA-8851805", "R-MMU-1250347", "R-SSC-5674135", "R-HSA-4086398", "R-CFA-6807878", "R-CFA-9748787", "R-CEL-193648", "R-SCE-5625740", "R-RNO-8849471", "R-HSA-5655291", "R-GGA-210993", "R-DDI-5687128", "R-DME-6811436", "R-CFA-5625970", "R-DDI-392517", "R-RNO-392451", "R-MMU-5625970", "R-CEL-9615933", "R-CEL-3928665", "R-XTR-354192", "R-PFA-1660499", "R-DDI-3928662", "R-HSA-9634285", "R-RNO-180336", "R-DRE-4086400", "R-CEL-166208", "R-SPO-72163", "R-SPO-8876198", "R-CEL-6811434", "R-HSA-5654688", "R-SPO-6807878", "R-MMU-389359", "R-MMU-9607240", "R-SCE-5620912", "R-SSC-2179392", "R-RNO-5654704", "R-CEL-354194", "R-CEL-5627083", "R-MMU-9639288", "R-CEL-416482", "R-BTA-9035034", "R-HSA-4420097", "R-CEL-6811440", "R-RNO-392517", "R-CFA-2173791", "R-DME-1660499", "R-HSA-9753512", "R-MMU-5668599", "R-PFA-1660514", "R-HSA-9629569", "R-DRE-416572", "R-DDI-5620916", "R-HSA-9665686", "R-CEL-9845576", "R-GGA-8876198", "R-CEL-8985586", "R-GGA-5621575", "R-RNO-8964616", "R-DME-5687128", "R-MMU-8875555", "R-BTA-193634", "R-SSC-212676", "R-CFA-9013106", "R-HSA-381676", "R-SPO-9013424", "R-BTA-114604", "R-RNO-8875555", "R-MMU-5654688", "R-RNO-5689896", "R-RNO-181429", "R-BTA-9013106", "R-MMU-375165", "R-CEL-5620922", "R-GGA-5654719", "R-MMU-1169092", "R-HSA-8876725", "R-DME-392451", "R-SCE-5627123", "R-CFA-204005", "R-RNO-5620912", "R-MMU-9845576", "R-DDI-9013149", "R-HSA-9032759", "R-DME-1660514", "R-DDI-381676", "R-CEL-8876198", "R-HSA-6802946", "R-CFA-6785631", "R-DME-8856828", "R-GGA-180336", "R-GGA-933542", "R-RNO-9013106", "R-BTA-8849471", "R-DME-381676", "R-SSC-5658442", "R-MMU-5654719", "R-SPO-983170", "R-DRE-392451", "R-DME-9013407", "R-DME-8854214", "R-GGA-6811436", "R-RNO-6811434", "R-HSA-5627083", "R-CEL-392517", "R-HSA-6807878", "R-CFA-416550", "R-MMU-3928663", "R-SCE-8854214", "R-BTA-5625900", "R-CFA-5689896", "R-CEL-180336", "R-CFA-114604", "R-BTA-983170", "R-RNO-5625900", "R-BTA-9013408", "R-RNO-5218921", "R-DRE-9607240", "R-SSC-8851805", "R-SSC-5654688", "R-DRE-193634", "R-RNO-186763", "R-MMU-8857538", "R-HSA-9696273", "R-CEL-5654704", "R-DRE-3928663", "R-RNO-9013026", "R-BTA-5689880", "R-MMU-3928665", "R-HSA-2871796", "R-MMU-181430", "R-MMU-933542", "R-SPO-5578749", "R-SCE-8980692", "R-HSA-9662360", "R-BTA-6811558", "R-CEL-9639288", "R-RNO-375165", "R-HSA-5389840", "R-HSA-6802955", "R-SCE-9696273", "R-DDI-6798695", "R-BTA-5627117", "R-CFA-9013148", "R-HSA-6802948", "R-DDI-983231", "R-RNO-5675221", "R-SCE-193648", "R-RNO-199992", "R-DDI-8876725", "R-CFA-3928662", "R-GGA-9607240", "R-RNO-8963888", "R-HSA-72163", "R-HSA-5654700", "R-CEL-1433557", "R-MMU-179812", "R-SSC-9013149", "R-DDI-1660514", "R-BTA-6811434", "R-DDI-9013418", "R-RNO-5654699", "R-MMU-5674135", "R-BTA-4086400", "R-BTA-5620916", "R-CFA-9013424", "R-HSA-5578749", "R-CFA-8876198", "R-CEL-210500", "R-RNO-5627083", "R-GGA-1963640", "R-HSA-199992", "R-SSC-1169092", "R-HSA-114608", "R-CFA-8849471", "R-CFA-418885", "R-RNO-5666185", "R-CEL-5625900", "R-RNO-354192", "R-HSA-9013148", "R-RNO-5674135", "R-HSA-6811436", "R-DDI-5628897", "R-RNO-2132295", "R-GGA-9648002", "R-BTA-5666185", "R-HSA-9696270", "R-HSA-167590", "R-SPO-204005", "R-SSC-4420097", "R-BTA-418885", "R-HSA-180336", "R-BTA-416482", "R-RNO-9013423", "R-DME-5654712", "R-HSA-193634", "R-SSC-9648002", "R-CEL-179812", "R-HSA-187706", "R-SCE-156902", "R-HSA-3928665", "R-MMU-9032759", "R-BTA-181429", "R-DME-186763", "R-CEL-5419276", "R-MMU-9696273", "R-HSA-5625970", "R-HSA-5668599", "R-DME-9639288", "R-HSA-6798695", "R-DDI-5218921", "R-CEL-210993", "R-HSA-8875555", "R-HSA-5419276", "R-SSC-5675221", "R-MMU-2173791", "R-CEL-9013409", "R-GGA-2029482", "R-MMU-4420097", "R-HSA-5654693", "R-DRE-9013406", "R-RNO-198203", "R-RNO-212676", "R-CFA-432040", "R-HSA-399955", "R-GGA-9013406", "R-RNO-9937383", "R-HSA-389977", "R-DME-193634", "R-CEL-5624138", "R-RNO-432722", "R-DDI-1483248", "R-SSC-181430", "R-BTA-1222556", "R-MMU-165159", "R-CEL-4086400", "R-GGA-1810476", "R-SSC-186763", "R-CEL-5663213", "R-GGA-525793", "R-XTR-6798695", "R-PFA-6811434", "R-MMU-6811440", "R-SCE-354192", "R-HSA-162658", "R-CFA-8875555", "R-SCE-9035034", "R-SPO-162658", "R-HSA-1632852", "R-BTA-5620924", "R-DRE-5654700", "R-HSA-9013407", "R-MMU-2179392", "R-SCE-9639288", "R-CEL-5663220", "R-RNO-8876198", "R-DRE-2179392", "R-GGA-4420097", "R-MMU-9013148", "R-BTA-372708", "R-CFA-9013149", "R-RNO-114608", "R-HSA-2565942", "R-CEL-3928663", "R-BTA-1660514", "R-DRE-5689896", "R-MMU-5658442", "R-HSA-6802953", "R-DDI-6811436", "R-DME-4086398", "R-HSA-1655829", "R-RNO-171007", "R-CEL-9634635", "R-MMU-5218920", "R-CEL-445144", "R-DRE-5625740", "R-BTA-5625970", "R-CEL-416572", "R-HSA-186763", "R-RNO-1169092", "R-HSA-9753510", "R-SSC-1963640", "R-DDI-6807878", "R-HSA-112412", "R-MMU-3928662", "R-HSA-9013406", "R-DME-179812", "R-SSC-182971", "R-DME-9013423", "R-HSA-9607240", "R-RNO-9615933", "R-CEL-3928664", "R-SSC-5218921", "R-HSA-264876", "R-CEL-1660514", "R-DME-5658442", "R-SPO-9639288", "R-DRE-8873719", "R-RNO-5687128", "R-MMU-9706019", "R-CFA-432722", "R-MMU-9013409", "R-MMU-5689896", "R-RNO-525793", "R-DME-5689896", "R-DRE-5621575", "R-SPO-5358493", "R-DME-9013148", "R-RNO-1632852", "R-MMU-5654706", "R-CEL-1257604", "R-BTA-2565942", "R-HSA-389359", "R-BTA-5626467", "R-HSA-114604", "R-DME-9013149", "R-RNO-6811440", "R-HSA-5620924", "R-SCE-5358493", "R-SSC-264642", "R-RNO-9013407", "R-DME-5627123", "R-HSA-983231", "R-CFA-9824585", "R-SSC-3928662", "R-RNO-193634", "R-MMU-432040", "R-DME-9648002", "R-HSA-209563", "R-DME-389359", "R-MMU-9646399", "R-GGA-983231", "R-SPO-6811434", "R-DME-416482", "R-DME-110523", "R-HSA-9726840", "R-PFA-5620916", "R-HSA-9031628", "R-MMU-5687128", "R-BTA-9629569", "R-MMU-5663220", "R-GGA-389359", "R-DRE-180336", "R-GGA-6811438", "R-RNO-5358493", "R-RNO-9035034", "R-HSA-933542", "R-HSA-9634635", "R-HSA-9665348", "R-BTA-9013148", "R-DME-5625740", "R-BTA-9013423", "R-BTA-6807878", "R-SSC-8854214", "R-SSC-5694530", "R-HSA-165054", "R-SSC-5627123", "R-CFA-416572", "R-HSA-9615710", "R-HSA-5654719", "R-HSA-9032845", "R-BTA-2132295", "R-BTA-264642", "R-GGA-5626467", "R-MMU-5626467", "R-HSA-5654712", "R-DME-8873719", "R-SCE-1660499", "R-CFA-182971", "R-SSC-888590", "R-DME-350480", "R-HSA-9636569", "R-DME-5666185", "R-CFA-5627123", "R-CFA-3928664", "R-MMU-5654693", "R-CFA-2029482", "R-HSA-5663220", "R-DDI-9013404", "R-MMU-525793", "R-SSC-5620912", "R-DME-9013420", "R-DRE-1433557", "R-MMU-204005", "R-RNO-8854214", "R-DME-3928663", "R-CFA-5626467", "R-CEL-156902", "R-PFA-6807878", "R-RNO-9013149", "R-MMU-9013404", "R-SSC-9013420", "R-DME-6811438", "R-DME-156902", "R-HSA-3928662", "R-CEL-9035034", "R-DME-9035034", "R-RNO-5625740", "R-SCE-9013149", "R-RNO-9013424", "R-DRE-209563", "R-MMU-5628897", "R-GGA-432722", "R-CEL-5654693", "R-DRE-9013106", "R-SCE-6811440", "R-BTA-9845576", "R-CEL-5358493", "R-DME-8980692", "R-DDI-5658442", "R-SSC-9013424", "R-DDI-5694530", "R-HSA-6784531", "R-CEL-193634", "R-HSA-2219530", "R-MMU-445144", "R-DME-5654688", "R-DDI-380972", "R-HSA-6785807", "R-MMU-5627083", "R-DME-354192", "R-BTA-170968", "R-GGA-6798695", "R-MMU-264642", "R-MMU-9634635", "R-CFA-5663220", "R-GGA-1169092", "R-SPO-165159", "R-DRE-5658442", "R-BTA-5694530", "R-DRE-9013425", "R-HSA-9674555", "R-SSC-171007", "R-HSA-198203", "R-RNO-4420097", "R-HSA-445989", "R-CFA-9706019", "R-SCE-9013423", "R-HSA-8873719", "R-HSA-5626467", "R-DDI-8849471", "R-HSA-5628897", "R-CEL-9013149", "R-SPO-156902", "R-RNO-1655829", "R-GGA-2424491", "R-CFA-5687128", "R-CEL-8943724", "R-SCE-9013406", "R-BTA-212676", "R-DME-5620916", "R-CFA-525793", "R-CFA-389359", "R-RNO-9648002", "R-RNO-170984", "R-HSA-171007", "R-GGA-171007", "R-DRE-5689880", "R-DDI-171007", "R-HSA-9013420", "R-RNO-6807878", "R-RNO-9706019", "R-DRE-5389840", "R-DME-5627117", "R-MMU-8876725", "R-DDI-5621575", "R-RNO-114604", "R-HSA-8985586", "R-DRE-392517", "R-RNO-5658442", "R-GGA-5654688", "R-MMU-9013026", "R-HSA-5358493", "R-RNO-8876725", "R-XTR-9013419", "R-DME-8849471", "R-RNO-888590", "R-HSA-5627117", "R-DDI-8854214", "R-MMU-6811438", "R-RNO-1250347", "R-CEL-181430", "R-HSA-6802952", "R-RNO-372708", "R-MMU-6811558", "R-CFA-3928663", "R-CFA-8854214", "R-GGA-354192", "R-RNO-416550", "R-RNO-5218920", "R-DDI-389359", "R-RNO-399954", "R-BTA-4420097", "R-SPO-9696270", "R-MMU-1810476", "R-GGA-2179392", "R-GGA-5663220", "R-CFA-2132295", "R-DRE-416550", "R-MMU-186763", "R-CEL-389359", "R-CFA-6811440", "R-MMU-6811434", "R-DDI-9634635", "R-BTA-9013425", "R-GGA-375165", "R-DME-6785631", "R-CEL-5674135", "R-CEL-212676", "R-HSA-9820960", "R-DME-416572", "R-HSA-9748787", "R-CEL-8851805", "R-BTA-8875555", "R-MMU-170984", "R-BTA-8980692"], "pathways": ["R-DME-5389840:r:Mitochondrial translation elongation", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-354192:r:Integrin signaling", "R-GGA-5673000:r:RAF activation", "R-GGA-9013424:r:RHOV GTPase cycle", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-BTA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2132295:r:MHC class II antigen presentation", "R-GGA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DRE-5625970:r:RHO GTPases activate KTN1", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CFA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DRE-179812:r:GRB2 events in EGFR signaling", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-180746:r:Nuclear import of Rev protein", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-9013408:r:RHOG GTPase cycle", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-DME-210993:r:Tie2 Signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-170968:r:Frs2-mediated activation", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-RNO-9748787:r:Azathioprine ADME", "R-DME-5673000:r:RAF activation", "R-SCE-199992:r:trans-Golgi Network Vesicle Budding", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-525793:r:Myogenesis", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-CFA-209563:r:Axonal growth stimulation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-445144:r:Signal transduction by L1", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-354192:r:Integrin signaling", "R-SCE-5620916:r:VxPx cargo-targeting to cilium", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-DRE-8851805:r:MET activates RAS signaling", "R-MMU-114608:r:Platelet degranulation", "R-SSC-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CFA-8873719:r:RAB geranylgeranylation", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-PFA-199992:r:trans-Golgi Network Vesicle Budding", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-186763:r:Downstream signal transduction", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-1169092:r:Activation of RAS in B cells", "R-DME-166208:r:mTORC1-mediated signalling", "R-DRE-5675221:r:Negative regulation of MAPK pathway", "R-DME-9013406:r:RHOQ GTPase cycle", "R-CFA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-DDI-156902:r:Peptide chain elongation", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-170968:r:Frs2-mediated activation", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-SSC-210500:r:Glutamate Neurotransmitter Release Cycle", "R-GGA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SPO-8876725:r:Protein methylation", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9845576:r:Glycosphingolipid transport", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SSC-8875656:r:MET receptor recycling", "R-DDI-1169092:r:Activation of RAS in B cells", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-DDI-156842:r:Eukaryotic Translation Elongation", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-SSC-204005:r:COPII-mediated vesicle transport", "R-CEL-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-MMU-8854214:r:TBC/RABGAPs", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-GGA-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-GGA-5658442:r:Regulation of RAS by GAPs", "R-GGA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SSC-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-5673000:r:RAF activation", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-CFA-8980692:r:RHOA GTPase cycle", "R-MMU-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-BTA-182971:r:EGFR downregulation", "R-HSA-2424491:r:DAP12 signaling", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-PFA-6811438:r:Intra-Golgi traffic", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-3371511:r:HSF1 activation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-8951936:r:RUNX3 regulates p14-ARF", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-DME-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DME-1632852:r:Macroautophagy", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-BTA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-GGA-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-DME-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-8876725:r:Protein methylation", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-CEL-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-392517:r:Rap1 signalling", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-354192:r:Integrin signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-SPO-9013420:r:RHOU GTPase cycle", "R-SPO-198203:r:PI3K/AKT activation", "R-MMU-3928664:r:Ephrin signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DDI-1632852:r:Macroautophagy", "R-GGA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-SSC-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-SCE-9696264:r:RND3 GTPase cycle", "R-DDI-9629569:r:Protein hydroxylation", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DDI-166208:r:mTORC1-mediated signalling", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-GGA-5654712:r:FRS-mediated FGFR4 signaling", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-SCE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CEL-198203:r:PI3K/AKT activation", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-8875656:r:MET receptor recycling", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-DDI-354192:r:Integrin signaling", "R-CFA-4086400:r:PCP/CE pathway", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-BTA-9013424:r:RHOV GTPase cycle", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-DME-4086400:r:PCP/CE pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-SPO-9013106:r:RHOC GTPase cycle", "R-DME-2424491:r:DAP12 signaling", "R-SSC-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-GGA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SCE-9013420:r:RHOU GTPase cycle", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-CFA-5627117:r:RHO GTPases Activate ROCKs", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-XTR-392517:r:Rap1 signalling", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-9748787:r:Azathioprine ADME", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-SCE-198203:r:PI3K/AKT activation", "R-DME-9629569:r:Protein hydroxylation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-DME-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-SCE-392517:r:Rap1 signalling", "R-DME-5625900:r:RHO GTPases activate CIT", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-CFA-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-1632852:r:Macroautophagy", "R-SCE-8873719:r:RAB geranylgeranylation", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-CEL-418885:r:DCC mediated attractive signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-9845576:r:Glycosphingolipid transport", "R-SPO-9013409:r:RHOJ GTPase cycle", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-CFA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DRE-5419276:r:Mitochondrial translation termination", "R-HSA-354192:r:Integrin signaling", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CEL-8876725:r:Protein methylation", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CFA-9013420:r:RHOU GTPase cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-156902:r:Peptide chain elongation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-8876725:r:Protein methylation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-8873719:r:RAB geranylgeranylation", "R-DME-198203:r:PI3K/AKT activation", "R-MMU-166208:r:mTORC1-mediated signalling", "R-MMU-2424491:r:DAP12 signaling", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-CFA-193648:r:NRAGE signals death through JNK", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-5625970:r:RHO GTPases activate KTN1", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-MMU-8963888:r:Chylomicron assembly", "R-DDI-8873719:r:RAB geranylgeranylation", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-MMU-1632852:r:Macroautophagy", "R-DRE-1250347:r:SHC1 events in ERBB4 signaling", "R-CFA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-156902:r:Peptide chain elongation", "R-DDI-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SSC-2132295:r:MHC class II antigen presentation", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-182971:r:EGFR downregulation", "R-CEL-1169092:r:Activation of RAS in B cells", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-165159:r:MTOR signalling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-DME-9607240:r:FLT3 Signaling", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DRE-1169092:r:Activation of RAS in B cells", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-DRE-186763:r:Downstream signal transduction", "R-PFA-9845576:r:Glycosphingolipid transport", "R-DDI-6811438:r:Intra-Golgi traffic", "R-BTA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-171007:r:p38MAPK events", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-8854214:r:TBC/RABGAPs", "R-BTA-6785631:r:ERBB2 Regulates Cell Motility", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-165159:r:MTOR signalling", "R-DRE-198203:r:PI3K/AKT activation", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-9013420:r:RHOU GTPase cycle", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SSC-6798695:r:Neutrophil degranulation", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SSC-5626467:r:RHO GTPases activate IQGAPs", "R-CFA-5625740:r:RHO GTPases activate PKNs", "R-RNO-166208:r:mTORC1-mediated signalling", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-GGA-9013408:r:RHOG GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-SSC-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-GGA-392517:r:Rap1 signalling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-GGA-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-3928664:r:Ephrin signaling", "R-CFA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SSC-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DDI-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-BTA-6811438:r:Intra-Golgi traffic", "R-BTA-209563:r:Axonal growth stimulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-CEL-5626467:r:RHO GTPases activate IQGAPs", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-199992:r:trans-Golgi Network Vesicle Budding", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-CEL-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-CEL-8854214:r:TBC/RABGAPs", "R-GGA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-5674135:r:MAP2K and MAPK activation", "R-HSA-3928664:r:Ephrin signaling", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-9648002:r:RAS processing", "R-CFA-9032759:r:NTRK2 activates RAC1", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SPO-5694530:r:Cargo concentration in the ER", "R-SSC-5654719:r:SHC-mediated cascade:FGFR4", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CFA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-DRE-8875656:r:MET receptor recycling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-5627117:r:RHO GTPases Activate ROCKs", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9648002:r:RAS processing", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-525793:r:Myogenesis", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-6787450:r:tRNA modification in the mitochondrion", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-DRE-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-CFA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-9013409:r:RHOJ GTPase cycle", "R-SPO-8873719:r:RAB geranylgeranylation", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-CEL-6811438:r:Intra-Golgi traffic", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-SSC-2871796:r:FCERI mediated MAPK activation", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-SSC-179812:r:GRB2 events in EGFR signaling", "R-BTA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-CEL-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SSC-5654704:r:SHC-mediated cascade:FGFR3", "R-SSC-2424491:r:DAP12 signaling", "R-SPO-9035034:r:RHOF GTPase cycle", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CFA-5625900:r:RHO GTPases activate CIT", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-SCE-165159:r:MTOR signalling", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-165159:r:MTOR signalling", "R-BTA-8854214:r:TBC/RABGAPs", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-5673000:r:RAF activation", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-RNO-9607240:r:FLT3 Signaling", "R-CEL-5673000:r:RAF activation", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-525793:r:Myogenesis", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-165159:r:MTOR signalling", "R-DME-3928664:r:Ephrin signaling", "R-SPO-389359:r:CD28 dependent Vav1 pathway", "R-GGA-9013420:r:RHOU GTPase cycle", "R-GGA-8875555:r:MET activates RAP1 and RAC1", "R-SSC-8963888:r:Chylomicron assembly", "R-RNO-156902:r:Peptide chain elongation", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-5694530:r:Cargo concentration in the ER", "R-CFA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-4086400:r:PCP/CE pathway", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-SSC-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-209563:r:Axonal growth stimulation", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-8851805:r:MET activates RAS signaling", "R-CFA-8875656:r:MET receptor recycling", "R-BTA-156902:r:Peptide chain elongation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CFA-198203:r:PI3K/AKT activation", "R-DRE-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-9648002:r:RAS processing", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CFA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-CFA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-SSC-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-SCE-9013409:r:RHOJ GTPase cycle", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-5694530:r:Cargo concentration in the ER", "R-CFA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-8963888:r:Chylomicron assembly", "R-SCE-9013106:r:RHOC GTPase cycle", "R-MMU-8873719:r:RAB geranylgeranylation", "R-CFA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-CEL-8873719:r:RAB geranylgeranylation", "R-SCE-6811438:r:Intra-Golgi traffic", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9013420:r:RHOU GTPase cycle", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CFA-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-182971:r:EGFR downregulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-CFA-2424491:r:DAP12 signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-GGA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-CFA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DME-114604:r:GPVI-mediated activation cascade", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-9013424:r:RHOV GTPase cycle", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-GGA-8875656:r:MET receptor recycling", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-SPO-9696273:r:RND1 GTPase cycle", "R-CFA-9013408:r:RHOG GTPase cycle", "R-DRE-1963640:r:GRB2 events in ERBB2 signaling", "R-SSC-180336:r:SHC1 events in EGFR signaling", "R-HSA-164944:r:Nef and signal transduction", "R-BTA-392517:r:Rap1 signalling", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-8876725:r:Protein methylation", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-SPO-9696264:r:RND3 GTPase cycle", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-XTR-8875555:r:MET activates RAP1 and RAC1", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SSC-525793:r:Myogenesis", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-SPO-6811438:r:Intra-Golgi traffic", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-CEL-5627123:r:RHO GTPases activate PAKs", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SSC-9696264:r:RND3 GTPase cycle", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-418885:r:DCC mediated attractive signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-BTA-114608:r:Platelet degranulation", "R-CFA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-5625740:r:RHO GTPases activate PKNs", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SSC-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-350407:r:RHO1 GTPase cycle", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-GGA-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-156902:r:Peptide chain elongation", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-209563:r:Axonal growth stimulation", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-GGA-182971:r:EGFR downregulation", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-BTA-198203:r:PI3K/AKT activation", "R-SSC-9607240:r:FLT3 Signaling", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-GGA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-9607240:r:FLT3 Signaling", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-4086398:r:Ca2+ pathway", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-4086400:r:PCP/CE pathway", "R-SPO-8854214:r:TBC/RABGAPs", "R-MMU-392517:r:Rap1 signalling", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-5673000:r:RAF activation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DRE-5673000:r:RAF activation", "R-CFA-9013407:r:RHOH GTPase cycle", "R-DRE-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-193648:r:NRAGE signals death through JNK", "R-DRE-9013026:r:RHOB GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-GGA-5625970:r:RHO GTPases activate KTN1", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-SCE-5626467:r:RHO GTPases activate IQGAPs", "R-CEL-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-CEL-9748787:r:Azathioprine ADME", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-171007:r:p38MAPK events", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-SSC-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-199992:r:trans-Golgi Network Vesicle Budding", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-GGA-5218921:r:VEGFR2 mediated cell proliferation", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-SPO-199992:r:trans-Golgi Network Vesicle Budding", "R-DRE-9646399:r:Aggrephagy", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-GGA-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DDI-9648002:r:RAS processing", "R-MMU-9629569:r:Protein hydroxylation", "R-SCE-9696270:r:RND2 GTPase cycle", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-SCE-389359:r:CD28 dependent Vav1 pathway", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-8873719:r:RAB geranylgeranylation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-5694530:r:Cargo concentration in the ER", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-SSC-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-170968:r:Frs2-mediated activation", "R-SSC-210993:r:Tie2 Signaling", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-SCE-5694530:r:Cargo concentration in the ER", "R-GGA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-6811438:r:Intra-Golgi traffic", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-354192:r:Integrin signaling", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-DME-171007:r:p38MAPK events", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-179812:r:GRB2 events in EGFR signaling", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-DDI-199992:r:trans-Golgi Network Vesicle Budding", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-SSC-5625970:r:RHO GTPases activate KTN1", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-9748787:r:Azathioprine ADME", "R-HSA-525793:r:Myogenesis", "R-DME-450728:r:Inhibition of actin polymerization", "R-BTA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SSC-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-4086398:r:Ca2+ pathway", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-8875656:r:MET receptor recycling", "R-RNO-182971:r:EGFR downregulation", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-GGA-8854214:r:TBC/RABGAPs", "R-DRE-9648002:r:RAS processing", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-MMU-4086398:r:Ca2+ pathway", "R-CFA-8964616:r:G beta:gamma signalling through CDC42", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-8963888:r:Chylomicron assembly", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-SSC-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-DDI-5673000:r:RAF activation", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-8875656:r:MET receptor recycling", "R-DDI-445144:r:Signal transduction by L1", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SPO-5626467:r:RHO GTPases activate IQGAPs", "R-SPO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SSC-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-210993:r:Tie2 Signaling", "R-RNO-445144:r:Signal transduction by L1", "R-DME-9845576:r:Glycosphingolipid transport", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CFA-445144:r:Signal transduction by L1", "R-SSC-114604:r:GPVI-mediated activation cascade", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-CEL-9648002:r:RAS processing", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DME-8876725:r:Protein methylation", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-BTA-170984:r:ARMS-mediated activation", "R-SSC-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DME-182971:r:EGFR downregulation", "R-CEL-170968:r:Frs2-mediated activation", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DRE-9013419:r:RHOT2 GTPase cycle", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-SSC-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-8854214:r:TBC/RABGAPs", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-DDI-165159:r:MTOR signalling", "R-GGA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-SCE-6798695:r:Neutrophil degranulation", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-CFA-9035034:r:RHOF GTPase cycle", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-CFA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-8851805:r:MET activates RAS signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-HSA-4086398:r:Ca2+ pathway", "R-CFA-6807878:r:COPI-mediated anterograde transport", "R-CFA-9748787:r:Azathioprine ADME", "R-CEL-193648:r:NRAGE signals death through JNK", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-GGA-210993:r:Tie2 Signaling", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-CFA-5625970:r:RHO GTPases activate KTN1", "R-DDI-392517:r:Rap1 signalling", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-5625970:r:RHO GTPases activate KTN1", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-XTR-354192:r:Integrin signaling", "R-PFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-DRE-4086400:r:PCP/CE pathway", "R-CEL-166208:r:mTORC1-mediated signalling", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-SCE-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SSC-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CEL-5627083:r:RHO GTPases regulate CFTR trafficking", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-392517:r:Rap1 signalling", "R-CFA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9753512:r:Signaling by RAS GTPase mutants", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-PFA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9629569:r:Protein hydroxylation", "R-DRE-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DDI-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-CEL-9845576:r:Glycosphingolipid transport", "R-GGA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-BTA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SPO-9013424:r:RHOV GTPase cycle", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-GGA-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-1169092:r:Activation of RAS in B cells", "R-HSA-8876725:r:Protein methylation", "R-DME-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-CFA-204005:r:COPII-mediated vesicle transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9845576:r:Glycosphingolipid transport", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-DME-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CFA-6785631:r:ERBB2 Regulates Cell Motility", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-GGA-180336:r:SHC1 events in EGFR signaling", "R-GGA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9013106:r:RHOC GTPase cycle", "R-BTA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SSC-5658442:r:Regulation of RAS by GAPs", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DME-9013407:r:RHOH GTPase cycle", "R-DME-8854214:r:TBC/RABGAPs", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-CEL-392517:r:Rap1 signalling", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-SCE-8854214:r:TBC/RABGAPs", "R-BTA-5625900:r:RHO GTPases activate CIT", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-CFA-114604:r:GPVI-mediated activation cascade", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-9607240:r:FLT3 Signaling", "R-SSC-8851805:r:MET activates RAS signaling", "R-SSC-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9696273:r:RND1 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-9013026:r:RHOB GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SCE-9696273:r:RND1 GTPase cycle", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-5627117:r:RHO GTPases Activate ROCKs", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DDI-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-SCE-193648:r:NRAGE signals death through JNK", "R-RNO-199992:r:trans-Golgi Network Vesicle Budding", "R-DDI-8876725:r:Protein methylation", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-GGA-9607240:r:FLT3 Signaling", "R-RNO-8963888:r:Chylomicron assembly", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-BTA-4086400:r:PCP/CE pathway", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-CFA-9013424:r:RHOV GTPase cycle", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-CFA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-5627083:r:RHO GTPases regulate CFTR trafficking", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-SSC-1169092:r:Activation of RAS in B cells", "R-HSA-114608:r:Platelet degranulation", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-418885:r:DCC mediated attractive signaling", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-RNO-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-2132295:r:MHC class II antigen presentation", "R-GGA-9648002:r:RAS processing", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-418885:r:DCC mediated attractive signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-9648002:r:RAS processing", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-SCE-156902:r:Peptide chain elongation", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-186763:r:Downstream signal transduction", "R-CEL-5419276:r:Mitochondrial translation termination", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-5625970:r:RHO GTPases activate KTN1", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-DME-193634:r:Axonal growth inhibition (RHOA activation)", "R-CEL-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-SSC-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-165159:r:MTOR signalling", "R-CEL-4086400:r:PCP/CE pathway", "R-GGA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-SSC-186763:r:Downstream signal transduction", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-525793:r:Myogenesis", "R-XTR-6798695:r:Neutrophil degranulation", "R-PFA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-354192:r:Integrin signaling", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-CFA-8875555:r:MET activates RAP1 and RAC1", "R-SCE-9035034:r:RHOF GTPase cycle", "R-SPO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-1632852:r:Macroautophagy", "R-BTA-5620924:r:Intraflagellar transport", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-BTA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-BTA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-DDI-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-4086398:r:Ca2+ pathway", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-RNO-171007:r:p38MAPK events", "R-CEL-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-BTA-5625970:r:RHO GTPases activate KTN1", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-1169092:r:Activation of RAS in B cells", "R-HSA-9753510:r:Signaling by RAS GAP mutants", "R-SSC-1963640:r:GRB2 events in ERBB2 signaling", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-SSC-182971:r:EGFR downregulation", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-3928664:r:Ephrin signaling", "R-SSC-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-264876:r:Insulin processing", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-DRE-8873719:r:RAB geranylgeranylation", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-CFA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-RNO-525793:r:Myogenesis", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-DME-9013148:r:CDC42 GTPase cycle", "R-RNO-1632852:r:Macroautophagy", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-BTA-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-9013149:r:RAC1 GTPase cycle", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-5620924:r:Intraflagellar transport", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-SSC-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CFA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-9648002:r:RAS processing", "R-HSA-209563:r:Axonal growth stimulation", "R-DME-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9646399:r:Aggrephagy", "R-GGA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DME-110523:r:TOR signaling pathway", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-PFA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9031628:r:NGF-stimulated transcription", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9629569:r:Protein hydroxylation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-GGA-389359:r:CD28 dependent Vav1 pathway", "R-DRE-180336:r:SHC1 events in EGFR signaling", "R-GGA-6811438:r:Intra-Golgi traffic", "R-RNO-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-SSC-8854214:r:TBC/RABGAPs", "R-SSC-5694530:r:Cargo concentration in the ER", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-SSC-5627123:r:RHO GTPases activate PAKs", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-BTA-2132295:r:MHC class II antigen presentation", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-GGA-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-8873719:r:RAB geranylgeranylation", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CFA-182971:r:EGFR downregulation", "R-SSC-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-HSA-9636569:r:Suppression of autophagy", "R-DME-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-CFA-5627123:r:RHO GTPases activate PAKs", 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"R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DRE-209563:r:Axonal growth stimulation", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-9013106:r:RHOC GTPase cycle", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-BTA-9845576:r:Glycosphingolipid transport", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-DME-8980692:r:RHOA GTPase cycle", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-SSC-9013424:r:RHOV GTPase cycle", "R-DDI-5694530:r:Cargo concentration in the ER", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-CEL-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5627083:r:RHO GTPases regulate CFTR trafficking", "R-DME-354192:r:Integrin signaling", "R-BTA-170968:r:Frs2-mediated activation", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-CFA-5663220:r:RHO GTPases Activate Formins", "R-GGA-1169092:r:Activation of RAS in B cells", "R-SPO-165159:r:MTOR signalling", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-BTA-5694530:r:Cargo concentration in the ER", "R-DRE-9013425:r:RHOT1 GTPase cycle", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-SSC-171007:r:p38MAPK events", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CFA-9706019:r:RHOBTB3 ATPase cycle", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-HSA-8873719:r:RAB geranylgeranylation", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-SPO-156902:r:Peptide chain elongation", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-GGA-2424491:r:DAP12 signaling", "R-CFA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-CFA-525793:r:Myogenesis", "R-CFA-389359:r:CD28 dependent Vav1 pathway", "R-RNO-9648002:r:RAS processing", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-171007:r:p38MAPK events", "R-GGA-171007:r:p38MAPK events", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DDI-171007:r:p38MAPK events", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-DME-5627117:r:RHO GTPases Activate ROCKs", "R-MMU-8876725:r:Protein methylation", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DRE-392517:r:Rap1 signalling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-GGA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-8876725:r:Protein methylation", "R-XTR-9013419:r:RHOT2 GTPase cycle", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-DDI-8854214:r:TBC/RABGAPs", "R-MMU-6811438:r:Intra-Golgi traffic", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CFA-3928663:r:EPHA-mediated growth cone collapse", "R-CFA-8854214:r:TBC/RABGAPs", "R-GGA-354192:r:Integrin signaling", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-9696270:r:RND2 GTPase cycle", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-GGA-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-CFA-2132295:r:MHC class II antigen presentation", "R-DRE-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-186763:r:Downstream 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"pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005227": {"description": "Putative pre-16S rRNA nuclease", "go_ids": ["GO:0006364"], "go_terms": ["GO:0006364:rRNA processing:P"], "name": "YqgF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005229": {"description": "Endoribonuclease YicC/YloC-like", "go_ids": ["GO:0004521"], "go_terms": ["GO:0004521:RNA endonuclease activity:F"], "name": "YicC/YloC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005230": {"description": "TraB, bacterial/archaeal", "go_ids": [], "go_terms": [], "name": "TraB_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005231": {"description": "Nascent polypeptide-associated complex (NAC), archaeal", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "NAC_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005232": {"description": "Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase LarE-like", "go_ids": 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["PWY-7977:t:L-methionine biosynthesis IV", "PWY-6562:t:norspermidine biosynthesis", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8088:t:dipicolinate biosynthesis", "PWY-8296:t:cremeomycin biosynthesis", "PWY-6559:t:spermidine biosynthesis II", "PWY-6160:t:3-dehydroquinate biosynthesis II (archaea)", "PWY-5097:t:L-lysine biosynthesis VI", "PWY-7153:t:grixazone biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Family"}, "IPR005261": {"description": "Inner membrane protein YohK-like", "go_ids": [], "go_terms": [], "name": "YohK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005262": {"description": "MJ1255-like", "go_ids": [], "go_terms": [], "name": "MJ1255-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005263": {"description": "4-hydroxy-tetrahydrodipicolinate synthase, DapA", "go_ids": ["GO:0008840", "GO:0009085"], "go_terms": ["GO:0008840:4-hydroxy-tetrahydrodipicolinate synthase activity:F", "GO:0009085:L-lysine biosynthetic process:P"], "name": "DapA", "pathway_ids": ["PWY-5097", "PWY-2942", "PWY-8088", "PWY-2941"], "pathways": ["PWY-5097:t:L-lysine biosynthesis VI", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8088:t:dipicolinate biosynthesis", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Family"}, "IPR005264": {"description": "N-acetylneuraminate lyase", "go_ids": ["GO:0005975", "GO:0008747"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0008747:N-acetylneuraminate lyase activity:F"], "name": "NanA", "pathway_ids": ["PWY-7581", "R-SSC-4085001", "R-BTA-4085001", "R-HSA-4085001"], "pathways": ["PWY-7581:t:N-acetylneuraminate and N-acetylmannosamine degradation II", "R-SSC-4085001:r:Sialic acid metabolism", "R-BTA-4085001:r:Sialic acid metabolism", "R-HSA-4085001:r:Sialic acid metabolism"], "type": "Family"}, "IPR005265": {"description": "Protoporphyrinogen oxidase HemJ-like", "go_ids": [], "go_terms": [], "name": "HemJ-like", "pathway_ids": ["PWY-6944", "PWY-6945", "PWY-8152", "PWY-6948", "PWY-7552", "PWY-6672", "PWY-8155", "PWY-6061", "PWY-6279", "PWY-8151", "PWY-6946", "PWY-7636"], "pathways": ["PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7552:t:heme b biosynthesis III (from siroheme)", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-8155:t:testosterone degradation (anaerobic)", "PWY-6061:t:bile acid biosynthesis, neutral pathway", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7636:t:astaxanthin biosynthesis (flowering plants)"], "type": "Family"}, "IPR005266": {"description": "Uncharacterised protein family UPF0128", "go_ids": [], "go_terms": [], "name": "UPF0128", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005267": {"description": "Glycerol-3-phosphate transporter", "go_ids": ["GO:0015169", "GO:0015794", "GO:0016020"], "go_terms": ["GO:0015169:glycerol-3-phosphate transmembrane transporter activity:F", "GO:0015794:glycerol-3-phosphate transmembrane transport:P", "GO:0016020:membrane:C"], "name": "G3P_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005268": {"description": "Conserved hypothetical protein CHP00725", "go_ids": [], "go_terms": [], "name": "CHP00725", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005269": {"description": "Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG", "go_ids": ["GO:0009691", "GO:0016787"], "go_terms": ["GO:0009691:cytokinin biosynthetic process:P", "GO:0016787:hydrolase activity:F"], "name": "LOG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005270": {"description": "tRNA-dihydrouridine synthase, TIM-barrel, NifR3-related", "go_ids": [], "go_terms": [], "name": "tRNA_dU_NifR3-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005271": {"description": "Carboxy-S-adenosyl-L-methionine synthase", "go_ids": ["GO:0002098"], "go_terms": ["GO:0002098:tRNA wobble uridine modification:P"], "name": "CmoA", "pathway_ids": ["PWY-8344", "PWY-7694", "PWY-7693", "PWY-8039", "PWY-5"], "pathways": ["PWY-8344:t:ansamitocin P biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-5:t:canavanine biosynthesis"], "type": "Family"}, "IPR005272": {"description": "Protein of unknown function DUF406", "go_ids": [], "go_terms": [], "name": "DUF406", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005273": {"description": "Uracil-DNA glycosylase family 4", "go_ids": [], "go_terms": [], "name": "Ura-DNA_glyco_family4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005274": {"description": "Inner membrane protein YhjD", "go_ids": [], "go_terms": [], "name": "IM_pro_YhjD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005275": {"description": "L-fucose-proton symporter FucP", "go_ids": ["GO:0015535", "GO:0015756", "GO:0015150"], "go_terms": ["GO:0015535:fucose:proton symporter activity:F", "GO:0015756:fucose transmembrane transport:P", "GO:0015150:fucose transmembrane transporter activity:F"], "name": "Lfuc_symporter_FucP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005277": {"description": "Uncharacterised protein family, Major Facilitator Superfamily MSF4", "go_ids": [], "go_terms": [], "name": "Uncharacterised_MSF4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005279": {"description": "Dipeptide/tripeptide permease", "go_ids": ["GO:1904680", "GO:0015833", "GO:0016020"], "go_terms": ["GO:1904680:peptide transmembrane transporter activity:F", "GO:0015833:peptide transport:P", "GO:0016020:membrane:C"], "name": "Dipep/tripep_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005280": {"description": "Homoserine kinase, type II", "go_ids": ["GO:0004413", "GO:0009088"], "go_terms": ["GO:0004413:homoserine kinase activity:F", "GO:0009088:L-threonine biosynthetic process:P"], "name": "Homoserine_kinase_II", "pathway_ids": ["PWY-702"], "pathways": ["PWY-702:t:L-methionine biosynthesis II"], "type": "Family"}, "IPR005281": {"description": "Monovalent cation:proton antiporter, subunit B", "go_ids": ["GO:0008324", "GO:0006812", "GO:0016020"], "go_terms": ["GO:0008324:monoatomic cation transmembrane transporter activity:F", "GO:0006812:monoatomic cation transport:P", "GO:0016020:membrane:C"], "name": "CPA3_sub_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005282": {"description": "Lysosomal cystine transporter", "go_ids": [], "go_terms": [], "name": "LC_transporter", "pathway_ids": ["R-DME-5223345", "R-CEL-5223345", "R-SCE-9959399", "R-DDI-9959399", "R-MMU-5223345", "R-BTA-9959399", "R-MMU-9959399", "R-DME-9959399", "R-SCE-5223345", "R-DDI-5223345", "R-HSA-9959399", "R-CEL-9959399", "R-HSA-5223345", "R-BTA-5223345"], "pathways": ["R-DME-5223345:r:Miscellaneous transport and binding events", "R-CEL-5223345:r:Miscellaneous transport and binding events", "R-SCE-9959399:r:SLC-mediated transport of oligopeptides", "R-DDI-9959399:r:SLC-mediated transport of oligopeptides", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-BTA-9959399:r:SLC-mediated transport of oligopeptides", "R-MMU-9959399:r:SLC-mediated transport of oligopeptides", "R-DME-9959399:r:SLC-mediated transport of oligopeptides", "R-SCE-5223345:r:Miscellaneous transport and binding events", "R-DDI-5223345:r:Miscellaneous transport and binding events", "R-HSA-9959399:r:SLC-mediated transport of oligopeptides", "R-CEL-9959399:r:SLC-mediated transport of oligopeptides", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-BTA-5223345:r:Miscellaneous transport and binding events"], "type": "Family"}, "IPR005283": {"description": "Peroxysomal long chain fatty acyl transporter", "go_ids": ["GO:0005524", "GO:0016020", "GO:0005777", "GO:0015910", "GO:0005324", "GO:0042626"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016020:membrane:C", "GO:0005777:peroxisome:C", "GO:0015910:long-chain fatty acid import into peroxisome:P", "GO:0005324:long-chain fatty acid transmembrane transporter activity:F", "GO:0042626:ATPase-coupled transmembrane transporter activity:F"], "name": "FA_transporter", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741", "R-RNO-2046105", "R-HSA-5684045", "R-MMU-2046106", "R-SCE-1369062", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-9603798", "R-RNO-8980692", "R-RNO-2046106", "R-SCE-2046106", "R-MMU-1369062", "R-SCE-390247", "R-HSA-9013106", "R-HSA-2046105", "R-HSA-1369062", "R-SCE-9603798", "R-HSA-8980692", "R-SCE-2046105", "R-HSA-390247", "R-MMU-390247", "R-RNO-1369062", "R-RNO-9013106", "R-MMU-9603798", "R-HSA-2046106", "R-HSA-9603798", "R-MMU-2046105", "R-RNO-390247"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-HSA-5684045:r:Defective ABCD1 causes ALD", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SCE-1369062:r:ABC transporters in lipid homeostasis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SCE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-2046105:r:Linoleic acid (LA) metabolism", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Family"}, "IPR005284": {"description": "Pigment precursor permease/Protein ATP-binding cassette sub-family G", "go_ids": ["GO:0055085", "GO:0016020"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0016020:membrane:C"], "name": "Pigment_permease/Abcg", "pathway_ids": ["R-DME-189451", "R-HSA-8964058", "R-HSA-9029569", "R-DME-1369062", "R-DME-189483", "R-DME-9793528", "R-DME-9753281", "R-MMU-1369062", "R-DME-917937", "R-MMU-8964058", "R-HSA-1369062", "R-DME-1660661"], "pathways": ["R-DME-189451:r:Heme biosynthesis", "R-HSA-8964058:r:HDL remodeling", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DME-1369062:r:ABC transporters in lipid homeostasis", "R-DME-189483:r:Heme degradation", "R-DME-9793528:r:Ciprofloxacin ADME", "R-DME-9753281:r:Paracetamol ADME", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-DME-917937:r:Iron uptake and transport", "R-MMU-8964058:r:HDL remodeling", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-DME-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR005285": {"description": "Pleiotropic drug resistance protein PDR/CDR", "go_ids": ["GO:1990961", "GO:0042626", "GO:0016020"], "go_terms": ["GO:1990961:xenobiotic detoxification by transmembrane export across the plasma membrane:P", "GO:0042626:ATPase-coupled transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "Drug-R_PDR/CDR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005286": {"description": "Cell division protein FtsE", "go_ids": ["GO:0005524", "GO:0051301"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0051301:cell division:P"], "name": "Cell_div_FtsE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005287": {"description": "Conserved hypothetical protein CHP00375", "go_ids": [], "go_terms": [], "name": "CHP00375", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005288": {"description": "L-aspartate oxidase", "go_ids": ["GO:0008734", "GO:0009435"], "go_terms": ["GO:0008734:L-aspartate oxidase activity:F", "GO:0009435:NAD+ biosynthetic process:P"], "name": "NadB", "pathway_ids": ["PWY-7342", "PWY-5316"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5316:t:nicotine biosynthesis"], "type": "Family"}, "IPR005290": {"description": "Small ribosomal subunit protein uS15, bacteria", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uS15_bact", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-DRE-9937383", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-RNO-9937383", "R-DRE-5389840", "R-MMU-5389840", "R-DME-9937383", "R-RNO-5389840", "R-DRE-5419276"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR005292": {"description": "Multi drug resistance-associated protein", "go_ids": ["GO:0055085", "GO:0022857", "GO:0016020"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "MRP", "pathway_ids": ["PWY-8259", "PWY-8301", "PWY-4061", "PWY-6842", "PWY-4621", "PWY-6972", "R-HSA-2142691", "R-MMU-9753281", "R-BTA-382556", "R-RNO-9753281", "R-CFA-9753281", "R-BTA-9758890", "R-CFA-189483", "R-RNO-382556", "R-HSA-189483", "R-CFA-9758890", "R-MMU-189483", "R-RNO-9758890", "R-MMU-159418", "R-RNO-159418", "R-RNO-9754706", "R-BTA-189483", "R-HSA-9707564", "R-MMU-9749641", "R-BTA-9707564", "R-RNO-189483", "R-CFA-9707564", "R-MMU-382556", "R-HSA-5679001", "R-HSA-5690338", "R-HSA-382556", "R-BTA-2142691", "R-RNO-9707564", "R-HSA-9753281", "R-CFA-382556", "R-HSA-1660661", "R-HSA-9758890", "R-BTA-1660661", "R-HSA-9754706", "R-RNO-2142691", "R-MMU-9754706", "R-MMU-9758890", "R-CFA-2142691", "R-HSA-9818032", "R-HSA-9749641", "R-MMU-2142691", "R-RNO-9749641", "R-RNO-1660661", "R-HSA-159418", "R-BTA-9753281", "R-CFA-1660661", "R-MMU-9707564", "R-MMU-1660661"], "pathways": ["PWY-8259:t:arsenic detoxification (plants)", "PWY-8301:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis", "PWY-4061:t:glutathione-mediated detoxification I", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-4621:t:arsenic detoxification (bacteria)", "PWY-6972:t:oleandomycin activation/inactivation", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9753281:r:Paracetamol ADME", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-RNO-9753281:r:Paracetamol ADME", "R-CFA-9753281:r:Paracetamol ADME", "R-BTA-9758890:r:Transport of RCbl within the body", "R-CFA-189483:r:Heme degradation", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-189483:r:Heme degradation", "R-CFA-9758890:r:Transport of RCbl within the body", "R-MMU-189483:r:Heme degradation", "R-RNO-9758890:r:Transport of RCbl within the body", "R-MMU-159418:r:Recycling of bile acids and salts", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-9754706:r:Atorvastatin ADME", "R-BTA-189483:r:Heme degradation", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9749641:r:Aspirin ADME", "R-BTA-9707564:r:Cytoprotection by HMOX1", "R-RNO-189483:r:Heme degradation", "R-CFA-9707564:r:Cytoprotection by HMOX1", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5679001:r:Defective ABCC2 causes DJS", "R-HSA-5690338:r:Defective ABCC6 causes PXE", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9753281:r:Paracetamol ADME", "R-CFA-382556:r:ABC-family proteins mediated transport", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-9758890:r:Transport of RCbl within the body", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-9754706:r:Atorvastatin ADME", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9754706:r:Atorvastatin ADME", "R-MMU-9758890:r:Transport of RCbl within the body", "R-CFA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-RNO-9749641:r:Aspirin ADME", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-159418:r:Recycling of bile acids and salts", "R-BTA-9753281:r:Paracetamol ADME", "R-CFA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR005294": {"description": "ATP synthase, F1 complex, alpha subunit", "go_ids": ["GO:0015986", "GO:0046933", "GO:0045259"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P", "GO:0046933:proton-transporting ATP synthase activity, rotational mechanism:F", "GO:0045259:proton-transporting ATP synthase complex:C"], "name": "ATP_synth_F1_asu", "pathway_ids": ["PWY-7980", "R-DDI-9837999", "R-MMU-9837999", "R-CEL-9837999", "R-SSC-8949613", "R-DME-9837999", "R-MMU-163210", "R-CEL-163210", "R-DME-163210", "R-CEL-8949613", "R-RNO-9837999", "R-HSA-8949613", "R-DME-8949613", "R-HSA-163210", "R-HSA-1268020", "R-SPO-9837999", "R-SCE-9837999", "R-SSC-9837999", "R-HSA-9837999", "R-RNO-163210", "R-RNO-8949613", "R-MMU-8949613", "R-SSC-163210"], "pathways": ["PWY-7980:t:ATP biosynthesis", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SSC-8949613:r:Cristae formation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-8949613:r:Cristae formation", "R-DME-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-SSC-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR005295": {"description": "IBV 3B protein", "go_ids": [], "go_terms": [], "name": "IBV_3B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005296": {"description": "IBV 3C protein", "go_ids": [], "go_terms": [], "name": "IBV_3C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005297": {"description": "Lipoprotein repeat", "go_ids": [], "go_terms": [], "name": "Lipoprotein_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR005298": {"description": "MAP domain", "go_ids": [], "go_terms": [], "name": "MAP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005299": {"description": "SAM dependent carboxyl methyltransferase", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "MeTrfase_7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005300": {"description": "Lytic transglycosylase MltA, domain B", "go_ids": ["GO:0004553"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "MltA_B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005301": {"description": "MOB kinase activator family", "go_ids": [], "go_terms": [], "name": "MOB_kinase_act_fam", "pathway_ids": ["R-DME-390150", "R-DME-390098", "R-MMU-2028269", "R-RNO-2028269", "R-DME-390089", "R-DME-2028269", "R-HSA-2028269", "R-DDI-2028269"], "pathways": ["R-DME-390150:r:DS ligand bound to FT receptor", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-MMU-2028269:r:Signaling by Hippo", "R-RNO-2028269:r:Signaling by Hippo", "R-DME-390089:r:Formation of the Hippo kinase cassette", "R-DME-2028269:r:Signaling by Hippo", "R-HSA-2028269:r:Signaling by Hippo", "R-DDI-2028269:r:Signaling by Hippo"], "type": "Family"}, "IPR005302": {"description": "Molybdenum cofactor sulfurase, C-terminal", "go_ids": ["GO:0003824", "GO:0030151", "GO:0030170"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0030151:molybdenum ion binding:F", "GO:0030170:pyridoxal phosphate binding:F"], "name": "MoCF_Sase_C", "pathway_ids": ["PWY-5963", "R-RNO-211945", "R-DME-947581", "R-DRE-947581", "R-HSA-211945", "R-MMU-211945", "R-MMU-947581", "R-DRE-211945", "R-BTA-211945", "R-DDI-947581", "R-CEL-947581", "R-HSA-947581", "R-BTA-947581"], "pathways": ["PWY-5963:t:molybdenum cofactor sulfulylation (eukaryotes)", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-DRE-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-MMU-947581:r:Molybdenum cofactor biosynthesis", "R-DRE-211945:r:Phase I - Functionalization of compounds", "R-BTA-211945:r:Phase I - Functionalization of compounds", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-CEL-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR005303": {"description": "Molybdenum cofactor sulfurase, middle domain", "go_ids": [], "go_terms": [], "name": "MOCOS_middle", "pathway_ids": ["PWY-5963", "R-RNO-211945", "R-DME-947581", "R-DRE-947581", "R-HSA-211945", "R-MMU-211945", "R-MMU-947581", "R-DRE-211945", "R-BTA-211945", "R-DDI-947581", "R-CEL-947581", "R-HSA-947581", "R-BTA-947581"], "pathways": ["PWY-5963:t:molybdenum cofactor sulfulylation (eukaryotes)", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-DRE-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-MMU-947581:r:Molybdenum cofactor biosynthesis", "R-DRE-211945:r:Phase I - Functionalization of compounds", "R-BTA-211945:r:Phase I - Functionalization of compounds", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-CEL-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR005304": {"description": "Ribosomal biogenesis, methyltransferase, EMG1/NEP1", "go_ids": ["GO:0070037", "GO:0070475"], "go_terms": ["GO:0070037:rRNA (pseudouridine) methyltransferase activity:F", "GO:0070475:rRNA base methylation:P"], "name": "Rbsml_bgen_MeTrfase_EMG1/NEP1", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-DME-6791226", "R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR005305": {"description": "Nepovirus coat protein, C-terminal", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Nepo_coat_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005306": {"description": "Nepovirus coat protein, N-terminal", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Nepo_coat_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005308": {"description": "Orn/Lys/Arg decarboxylase, N-terminal", "go_ids": ["GO:0016831"], "go_terms": ["GO:0016831:carboxy-lyase activity:F"], "name": "OKR_de-COase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005309": {"description": "PapG, chaperone-binding", "go_ids": [], "go_terms": [], "name": "PapG_chaper-bd_C", "pathway_ids": ["R-HSA-9638630"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells"], "type": "Domain"}, "IPR005310": {"description": "PapG, carbohydrate-binding domain", "go_ids": ["GO:0007155", "GO:0030246"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0030246:carbohydrate binding:F"], "name": "PapG_carb-bd_N", "pathway_ids": ["R-HSA-9638630"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells"], "type": "Domain"}, "IPR005311": {"description": "Penicillin-binding protein, dimerisation domain", "go_ids": ["GO:0008658"], "go_terms": ["GO:0008658:penicillin binding:F"], "name": "PBP_dimer", "pathway_ids": ["PWY-6471", "PWY-5265"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)"], "type": "Domain"}, "IPR005312": {"description": "Domain of unknown function DUF1759", "go_ids": [], "go_terms": [], "name": "DUF1759", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005313": {"description": "Peptidase N2", "go_ids": [], "go_terms": [], "name": "Peptidase_N2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005314": {"description": "Peptidase C50, separase", "go_ids": ["GO:0004197", "GO:0005634", "GO:0006508"], "go_terms": ["GO:0004197:cysteine-type endopeptidase 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"R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72649:r:Translation initiation complex formation", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-72649:r:Translation initiation complex formation", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-1799339:r:SRP-dependent 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the Exon Junction Complex (EJC)", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to 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{"description": "Sorting nexin, N-terminal", "go_ids": ["GO:0006886"], "go_terms": ["GO:0006886:intracellular protein transport:P"], "name": "Sorting_nexin_N", "pathway_ids": ["R-MMU-432722", "R-HSA-432722"], "pathways": ["R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR005330": {"description": "MHYT domain", "go_ids": [], "go_terms": [], "name": "MHYT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005331": {"description": "Sulfotransferase", "go_ids": ["GO:0008146", "GO:0016020"], "go_terms": ["GO:0008146:sulfotransferase activity:F", "GO:0016020:membrane:C"], "name": "Sulfotransferase", "pathway_ids": ["PWY-8045", "PWY-7831", "PWY-8381", "PWY-6558", "PWY-6546", "PWY-6568", "PWY-6567", "PWY-8358", "R-DRE-2022870", "R-GGA-2022928", "R-MMU-2022870", "R-CEL-2022928", "R-HSA-2022870", "R-HSA-975578", "R-MMU-9939291", "R-DME-2022923", "R-DRE-9939291", "R-DRE-975578", "R-DME-2022928", "R-DME-2022870", "R-HSA-2022923", "R-DRE-2022928", "R-DRE-2022923", "R-MMU-2022928", "R-RNO-975578", "R-HSA-9939291", "R-HSA-2022928", "R-MMU-975578", "R-RNO-9939291", "R-MMU-2022923", "R-RNO-2022870", "R-HSA-3595174"], "pathways": ["PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7831:t:ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-6546:t:brassinosteroids inactivation", "PWY-6568:t:dermatan sulfate biosynthesis", "PWY-6567:t:chondroitin sulfate biosynthesis", "PWY-8358:t:curacin A biosynthesis", "R-DRE-2022870:r:CS-GAG biosynthesis", "R-GGA-2022928:r:HS-GAG biosynthesis", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-DME-2022923:r:DS-GAG biosynthesis", 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degranulation"], "type": "Family"}, "IPR005335": {"description": "Terminase small subunit", "go_ids": ["GO:0051276"], "go_terms": ["GO:0051276:chromosome organization:P"], "name": "Terminase_ssu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005336": {"description": "Mitochondrial pyruvate carrier", "go_ids": ["GO:0006850", "GO:0005743"], "go_terms": ["GO:0006850:pyruvate import into mitochondria:P", "GO:0005743:mitochondrial inner membrane:C"], "name": "MPC", "pathway_ids": ["R-HSA-70268"], "pathways": ["R-HSA-70268:r:Pyruvate metabolism"], "type": "Family"}, "IPR005337": {"description": "RapZ-like family", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "RapZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005338": {"description": "Anhydro-N-acetylmuramic acid kinase", "go_ids": ["GO:0005524", "GO:0006040", "GO:0009254", "GO:0016773"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006040:amino sugar metabolic process:P", "GO:0009254:peptidoglycan turnover:P", "GO:0016773:phosphotransferase activity, alcohol group as acceptor:F"], "name": "Anhydro_N_Ac-Mur_kinase", "pathway_ids": ["PWY-7883"], "pathways": ["PWY-7883:t:peptidoglycan recycling II"], "type": "Family"}, "IPR005339": {"description": "GINS complex, subunit Psf1", "go_ids": ["GO:0000811", "GO:0006260"], "go_terms": ["GO:0000811:GINS complex:C", "GO:0006260:DNA replication:P"], "name": "GINS_Psf1", "pathway_ids": ["R-BTA-176974", "R-SCE-176974", "R-SPO-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-CEL-176974"], "pathways": ["R-BTA-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-CEL-176974:r:Unwinding of DNA"], "type": "Family"}, "IPR005341": {"description": "Mitochondrial import inner membrane translocase subunit Tim16", "go_ids": ["GO:0005744", "GO:0030150"], "go_terms": ["GO:0005744:TIM23 mitochondrial import inner membrane translocase complex:C", "GO:0030150:protein import into mitochondrial matrix:P"], "name": "Tim16", "pathway_ids": ["R-HSA-1268020"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR005343": {"description": "Nucleolar complex protein 2", "go_ids": [], "go_terms": [], "name": "Noc2", "pathway_ids": ["R-BTA-6804756", "R-MMU-6804756", "R-HSA-6804756", "R-DME-6804756"], "pathways": ["R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation"], "type": "Family"}, "IPR005344": {"description": "TMEM33/Pom33 family", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TMEM33/Pom33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005345": {"description": "PHF5-like", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "PHF5", "pathway_ids": ["R-DME-9770562", "R-HSA-72163", "R-SPO-9770562", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-RNO-9770562", "R-DME-72163", "R-RNO-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR005346": {"description": "RnfH protein", "go_ids": [], "go_terms": [], "name": "RnfH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005349": {"description": "TMEM14 family", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TMEM14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005350": {"description": "Uncharacterised protein family UPF0137", "go_ids": [], "go_terms": [], "name": "UPF0137", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005351": {"description": "PAT complex subunit Asterix", "go_ids": ["GO:0005789", "GO:0045048", "GO:0044183"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0045048:protein insertion into ER membrane:P", "GO:0044183:protein folding chaperone:F"], "name": "ASTER", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005352": {"description": "Erg28", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Erg28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005353": {"description": "Uncharacterised protein family UPF0146", "go_ids": [], "go_terms": [], "name": "UPF0146", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005354": {"description": "Uncharacterised protein family UPF0147", "go_ids": [], "go_terms": [], "name": "UPF0147", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005358": {"description": "Putative zinc- or iron-chelating domain containing protein", "go_ids": [], "go_terms": [], "name": "Puta_zinc/iron-chelating_dom", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005359": {"description": "Protein with unknown function UPF0154", "go_ids": [], "go_terms": [], "name": "UPF0154", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005361": {"description": "Uncharacterised protein family UPF0158", "go_ids": [], "go_terms": [], "name": "UPF0158", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005362": {"description": "Uncharacterised protein family UPF0164", "go_ids": [], "go_terms": [], "name": "UPF0164", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005363": {"description": "Uncharacterised protein family UPF0167", "go_ids": [], "go_terms": [], "name": "UPF0167", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005365": {"description": "Nitrogen permease regulator 3", "go_ids": ["GO:0032007"], "go_terms": ["GO:0032007:negative regulation of TOR signaling:P"], "name": "Npr3", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR005366": {"description": "ER membrane protein complex subunit 8/9", "go_ids": ["GO:0072546"], "go_terms": ["GO:0072546:EMC complex:C"], "name": "EMC8/9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005368": {"description": "UPF0175", "go_ids": [], "go_terms": [], "name": "UPF0175", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005369": {"description": "Uncharacterised protein family UPF0179", "go_ids": [], "go_terms": [], "name": "UPF0179", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005370": {"description": "Uncharacterised protein family UPF0180", "go_ids": [], "go_terms": [], "name": "UPF0180", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005371": {"description": "Uncharacterised protein family UPF0181", "go_ids": [], "go_terms": [], "name": "UPF0181", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005372": {"description": "Uncharacterised protein family UPF0182", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "UPF0182", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005373": {"description": "Phagosome assembly factor 1", "go_ids": [], "go_terms": [], "name": "PHAF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005374": {"description": "Bublin coiled-coil protein-like, eukaryota", "go_ids": [], "go_terms": [], "name": "BBLN_eukaryota", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005375": {"description": "Ubiquitin-fold modifier 1", "go_ids": ["GO:0071569"], "go_terms": ["GO:0071569:protein ufmylation:P"], "name": "UFM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005376": {"description": "Adenovirus DNA-binding, zinc-binding domain", "go_ids": ["GO:0003677", "GO:0006260", "GO:0008270"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006260:DNA replication:P", "GO:0008270:zinc ion binding:F"], "name": "Adenovirus_DNA-bd_zn-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005378": {"description": "Vacuolar protein sorting-associated protein 35", "go_ids": ["GO:0030906", "GO:0042147", "GO:0015031"], "go_terms": ["GO:0030906:retromer, cargo-selective complex:C", "GO:0042147:retrograde transport, endosome to Golgi:P", "GO:0015031:protein transport:P"], "name": "Vps35", "pathway_ids": ["R-BTA-3238698", "R-MMU-3238698", "R-SCE-3238698", "R-DDI-3238698", "R-SPO-3238698", "R-HSA-3238698"], "pathways": ["R-BTA-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-SCE-3238698:r:WNT ligand biogenesis and trafficking", "R-DDI-3238698:r:WNT ligand biogenesis and trafficking", "R-SPO-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking"], "type": "Family"}, "IPR005379": {"description": "Factor of DNA methylation 1-5/IDN2 , domain XH", "go_ids": [], "go_terms": [], "name": "FDM1-5/IDN2_XH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005380": {"description": "XS domain", "go_ids": ["GO:0031047"], "go_terms": ["GO:0031047:regulatory ncRNA-mediated gene silencing:P"], "name": "XS_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005381": {"description": "Zinc finger-XS domain", "go_ids": ["GO:0031047"], "go_terms": ["GO:0031047:regulatory ncRNA-mediated gene silencing:P"], "name": "Znf-XS_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005384": {"description": "Duffy antigen/chemokine receptor", "go_ids": ["GO:0016020", "GO:0070098", "GO:0006954", "GO:0019956"], "go_terms": ["GO:0016020:membrane:C", "GO:0070098:chemokine-mediated signaling pathway:P", "GO:0006954:inflammatory response:P", "GO:0019956:chemokine binding:F"], "name": "Duffy_chemokine_rcpt", "pathway_ids": ["R-HSA-375276"], "pathways": ["R-HSA-375276:r:Peptide ligand-binding receptors"], "type": "Family"}, "IPR005398": {"description": "Tubby, N-terminal", "go_ids": [], "go_terms": [], "name": "Tubby_N", "pathway_ids": ["R-HSA-5610787", "R-MMU-5610787"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR005399": {"description": "Potassium channel, voltage-dependent, beta subunit, KCNAB-related", "go_ids": [], "go_terms": [], "name": "K_chnl_volt-dep_bsu_KCNAB-rel", "pathway_ids": ["PWY-5882", "PWY-5848", "PWY-7045", "PWY-5751", "PWY-7825", "PWY-7788", "PWY-5666", "PWY-8132", "PWY-8426", "PWY-5392", "PWY-6627", "PWY-6946", "PWY-7300", "PWY-6392", "PWY-6945", "PWY-6302", "PWY-8238", "PWY-7948", "PWY-7689", "PWY-8029", "PWY-7321", "PWY-7340", "PWY-7385", "PWY-7440", "PWY-7726", "PWY-5972", "PWY-7692", "PWY-1186", "PWY-8370", "PWY-7489", "PWY-7615", "PWY-7757", "PWY-7337", "PWY-6883", "PWY-7694", "PWY-7693", "PWY-6672", "PWY-7568", "PWY-3162", "PWY-5316", "PWY-5818", "PWY-7787", "PWY-6080", "PWY-7667", "PWY-6926", "PWY-6539", "PWY-5978", "PWY-6634", "PWY-5830", "PWY-8383", "PWY-6322", "PWY-8411", "PWY-7338", "PWY-6704", "PWY-6583", "PWY-8139", "PWY-5652", "PWY-8374", "PWY-7342", "PWY-7774", "PWY-6693", "PWY-7354", "PWY-7531", "PWY-7547", "PWY-6738", "PWY-8012", "PWY-6682", "PWY-7331", "PWY-7104", "PWY-7490", "PWY-6920", "PWY-7811", "PWY-7339", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7657", "PWY-8419", "PWY-5271", "PWY-7734", "PWY-7682", "PWY-7541", "PWY-6626", "PWY-6391", "PWY-6638", "PWY-8152", "PWY-3261", "PWY-8464", "PWY-6733", "PWY-321", "PWY-6637", "PWY-7660", "PWY-6944", "PWY-7288", "PWY-6659", "PWY-7301", "PWY-8367", "PWY-6786", "PWY-6973", "PWY-2541", "PWYG-321", "PWY-5883", "PWY-6053", "PWY-7042", "PWY-7742", "PWY-7621", "PWY-8410", "PWY-5867", "PWY-8214", "PWY-7554", "PWY-8409", "PWY-7814", "PWY-7557", "PWY-8297", "PWY-7403", "PWY-7241", "PWY-6948", "PWY-7610", "PWY-8155", "PWY-6974", "PWY-2601", "PWY-7396", "PWY-7695", "PWY-7304", "PWY-8058", "PWY-8366", "PWY-7043", "PWY-7520", "PWY-6863", "PWY-6976", "PWY-3722", "PWY-7352", "PWY-6989", "PWY-6061", "PWY-8408", "PWY-7649", "PWY-8397", "PWY-7613", "PWY-5782", "PWY-741", "PWY-7333", "PWY-5101", "PWY-7775", "PWY-1121", "PWY-7606", "PWY-7741", "PWY-7779", "R-HSA-6798695", "R-SPO-6798695", "R-BTA-1296072", "R-GGA-1296072", "R-HSA-1296072", "R-MMU-6798695", "R-BTA-6798695", "R-RNO-1296072", "R-RNO-6798695", "R-MMU-1296072"], "pathways": ["PWY-5882:t:epoxypseudoisoeugenol-2-methylbutanoate biosynthesis", "PWY-5848:t:cinchona alkaloids biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-5751:t:phenylethanol biosynthesis", "PWY-7825:t:juglone degradation", "PWY-7788:t:erythritol degradation II", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-5392:t:reductive TCA cycle II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-6392:t:meso-butanediol biosynthesis II", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-7692:t:bikaverin biosynthesis", "PWY-1186:t:L-homomethionine biosynthesis", "PWY-8370:t:leporin B biosynthesis", "PWY-7489:t:oryzalexin A, B, and C biosynthesis", "PWY-7615:t:pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)", "PWY-7757:t:bisphenol A degradation", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7568:t:L-galactose degradation", "PWY-3162:t:L-tryptophan degradation V (side chain pathway)", "PWY-5316:t:nicotine biosynthesis", "PWY-5818:t:validamycin biosynthesis", "PWY-7787:t:L-threitol degradation", "PWY-6080:t:4-ethylphenol degradation (anaerobic)", "PWY-7667:t:apicidin biosynthesis", "PWY-6926:t:pyrethrin I biosynthesis", "PWY-6539:t:(Z)-phenylmethanethial S-oxide biosynthesis", "PWY-5978:t:kanosamine biosynthesis I", "PWY-6634:t:3-sulfopropanediol degradation I", "PWY-5830:t:CDP-ascarylose biosynthesis", "PWY-8383:t:myxochelin A and B biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-6704:t:L-ascorbate degradation IV", "PWY-6583:t:pyruvate fermentation to butanol I", "PWY-8139:t:CDP-6-deoxy-D-gulose biosynthesis", "PWY-5652:t:2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA", "PWY-8374:t:antimycin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7774:t:propane degradation I", "PWY-6693:t:D-galactose degradation IV", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-6738:t:pinitol biosynthesis I", "PWY-8012:t:mupirocin biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7331:t:UDP-N-acetyl-beta-L-quinovosamine biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7490:t:patulin biosynthesis", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7657:t:dTDP-beta-L-digitoxose biosynthesis", "PWY-8419:t:L-canavanine degradation II", "PWY-5271:t:abscisic acid degradation to phaseic acid", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7682:t:arabidopyrone biosynthesis", "PWY-7541:t:1,2-propanediol biosynthesis from lactate (engineered)", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6391:t:meso-butanediol biosynthesis I", "PWY-6638:t:sulfolactate degradation III", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-3261:t:UDP-beta-L-rhamnose biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-6637:t:sulfolactate degradation II", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-6053:t:dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)", "PWY-7042:t:the visual cycle (insects)", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "PWY-5867:t:t-anethole biosynthesis", "PWY-8214:t:3-sulfopropanediol degradation II", "PWY-7554:t:heme d1 biosynthesis", "PWY-8409:t:cyathin biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-8297:t:6-diazo-5-oxo-L-norleucine biosynthesis", "PWY-7403:t:tetramethylpyrazine degradation", "PWY-7241:t:myo-inositol degradation II", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-8155:t:testosterone degradation (anaerobic)", "PWY-6974:t:dTDP-beta-L-olivose biosynthesis", "PWY-2601:t:isethionate degradation", "PWY-7396:t:butanol and isobutanol biosynthesis (engineered)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7304:t:3-amino-4,7-dihydroxy-coumarin biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8366:t:septacidin biosynthesis", "PWY-7043:t:11-cis-3-hydroxyretinal biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-3722:t:glycine betaine biosynthesis II (Gram-positive bacteria)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6989:t:(S)-camphor degradation", "PWY-6061:t:bile acid biosynthesis, neutral pathway", "PWY-8408:t:erinacine biosynthesis", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWY-5782:t:2-keto-L-gulonate biosynthesis", "PWY-741:t:p-cymene degradation to p-cumate", "PWY-7333:t:UDP-N-acetyl-alpha-D-fucosamine biosynthesis", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-7775:t:propane degradation II", "PWY-1121:t:suberin monomers biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-GGA-1296072:r:Voltage gated Potassium channels", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-1296072:r:Voltage gated Potassium channels"], "type": "Family"}, "IPR005412": {"description": "DNA-binding protein Fis", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Fis_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005413": {"description": "Low calcium response V antigen", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "LowCa_resp_V_Ag", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005414": {"description": "Guanine nucleotide exchange factor SopE", "go_ids": ["GO:0090630", "GO:0005085", "GO:0005576", "GO:0030036"], "go_terms": ["GO:0090630:activation of GTPase activity:P", "GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0005576:extracellular region:C", "GO:0030036:actin cytoskeleton organization:P"], "name": "SopE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005415": {"description": "Type III secretion system, low calcium response, chaperone LcrH/SycD", "go_ids": [], "go_terms": [], "name": "T3SS_Ca_resp_chp_LcrH/SycD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005416": {"description": "Type III secretion chaperone SycE", "go_ids": ["GO:0030254"], "go_terms": ["GO:0030254:protein secretion by the type III secretion system:P"], "name": "T3SS_chp_SycE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005427": {"description": "Effector protein BipC/T3SS SctB", "go_ids": [], "go_terms": [], "name": "BipC/SctB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005428": {"description": "CD36/scavenger receptor class B member 1", "go_ids": [], "go_terms": [], "name": "CD36/SCARB1/SNMP1", "pathway_ids": ["R-RNO-1236973", "R-HSA-6798695", "R-HSA-1989781", "R-HSA-8964011", "R-HSA-168188", "R-BTA-6798695", "R-RNO-3000471", "R-HSA-9841922", "R-RNO-114608", "R-HSA-114608", "R-BTA-114608", "R-DME-1236973", "R-HSA-3000471", "R-RNO-434313", "R-MMU-8964011", "R-HSA-5686938", "R-BTA-1236973", "R-BTA-3000471", "R-MMU-434313", "R-RNO-5686938", "R-HSA-166058", "R-MMU-3000471", "R-DME-6798695", "R-DME-114608", "R-HSA-381340", "R-HSA-1236973", "R-SSC-8964011", "R-HSA-6785807", "R-MMU-5686938", "R-RNO-8964011", "R-BTA-5686938", "R-MMU-1236973", "R-HSA-434313", "R-BTA-434313", "R-DME-434313", "R-HSA-5603041", "R-HSA-5602498", "R-HSA-1236974", "R-MMU-6798695", "R-SSC-3000471", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-RNO-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-8964011:r:HDL clearance", "R-HSA-168188:r:Toll Like Receptor TLR6:TLR2 Cascade", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-MMU-8964011:r:HDL clearance", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-BTA-3000471:r:Scavenging by Class B Receptors", "R-MMU-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-114608:r:Platelet degranulation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-SSC-8964011:r:HDL clearance", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964011:r:HDL clearance", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-1236973:r:Cross-presentation of 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a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR005488": {"description": "N-acetylmuramic acid 6-phosphate etherase MurQ", "go_ids": ["GO:0016835", "GO:0046348"], "go_terms": ["GO:0016835:carbon-oxygen lyase activity:F", "GO:0046348:amino sugar catabolic process:P"], "name": "Etherase_MurQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005489": {"description": "Protein of unknown function DUF257", "go_ids": [], "go_terms": [], "name": "DUF257", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005490": {"description": "L,D-transpeptidase catalytic domain", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "LD_TPept_cat_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005491": {"description": "ENT domain", "go_ids": [], "go_terms": [], "name": "ENT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005492": {"description": "Leucine-rich glioma-inactivated , EPTP repeat", "go_ids": [], "go_terms": [], "name": "EPTP", "pathway_ids": ["R-HSA-9619665", "R-HSA-5682910", "R-RNO-5682910", "R-MMU-5682910", "R-BTA-5682910"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-5682910:r:LGI-ADAM interactions", "R-RNO-5682910:r:LGI-ADAM interactions", "R-MMU-5682910:r:LGI-ADAM interactions", "R-BTA-5682910:r:LGI-ADAM interactions"], "type": "Repeat"}, "IPR005493": {"description": "Ribonuclease E inhibitor RraA/RraA-like protein", "go_ids": [], "go_terms": [], "name": "RraA/RraA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005494": {"description": "Glutathionylspermidine synthase, pre-ATP-grasp-like domain", "go_ids": [], "go_terms": [], "name": "GSPS_pre-ATP-grasp-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005495": {"description": "Permease LptG/LptF-related", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "LptG/LptF_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005496": {"description": "Integral membrane protein TerC", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Integral_membrane_TerC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005497": {"description": "Cytochrome b6-f complex, subunit 8", "go_ids": ["GO:0009512", "GO:0017004"], "go_terms": ["GO:0009512:cytochrome b6f complex:C", "GO:0017004:cytochrome complex assembly:P"], "name": "Cytochrome_b6-f_cplx_su8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005498": {"description": "Type IV secretion system, VirB10/TraB/TrbI", "go_ids": [], "go_terms": [], "name": "T4SS_VirB10/TraB/TrbI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005499": {"description": "6-carboxyhexanoate--CoA ligase", "go_ids": ["GO:0009102", "GO:0042410", "GO:0005524"], "go_terms": ["GO:0009102:biotin biosynthetic process:P", "GO:0042410:6-carboxyhexanoate-CoA ligase activity:F", "GO:0005524:ATP binding:F"], "name": "BioW", "pathway_ids": ["PWY-6578"], "pathways": ["PWY-6578:t:8-amino-7-oxononanoate biosynthesis III"], "type": "Family"}, "IPR005500": {"description": "Protein of unknown function DUF309", "go_ids": [], "go_terms": [], "name": "DUF309", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005501": {"description": "LamB/YcsF/PxpA-like", "go_ids": [], "go_terms": [], "name": "LamB/YcsF/PxpA-like", "pathway_ids": ["PWY-4041", "PWY-7942"], "pathways": ["PWY-4041:t:gamma-glutamyl cycle", "PWY-7942:t:5-oxo-L-proline metabolism"], "type": "Family"}, "IPR005502": {"description": "ADP-ribosylation/Crystallin J1", "go_ids": [], "go_terms": [], "name": "Ribosyl_crysJ1", "pathway_ids": ["R-HSA-110362", "R-DRE-110362", "R-MMU-110362", "R-XTR-110362"], "pathways": ["R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-XTR-110362:r:POLB-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR005503": {"description": "Flagellar basal body-associated protein FliL", "go_ids": ["GO:0006935", "GO:0009425", "GO:0071973"], "go_terms": ["GO:0006935:chemotaxis:P", "GO:0009425:bacterial-type flagellum basal body:C", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "FliL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005506": {"description": "Protein of unknown function DUF312, ALF", "go_ids": [], "go_terms": [], "name": "DUF312_ALF", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR005507": {"description": "Immediate-early protein 2-like", "go_ids": [], "go_terms": [], "name": "IE2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005508": {"description": "B3 domain-containing protein At2g31720-like", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "At2g31720-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005509": {"description": "A-factor biosynthesis hotdog domain", "go_ids": [], "go_terms": [], "name": "AfsA_hotdog_dom", "pathway_ids": ["PWY-7882", "PWY-7881", "PWY-7878"], "pathways": ["PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis"], "type": "Domain"}, "IPR005510": {"description": "CRISPR type III-associated RAMP protein Csm4", "go_ids": [], "go_terms": [], "name": "Csm4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005511": {"description": "Senescence marker protein-30 (SMP-30)", "go_ids": [], "go_terms": [], "name": "SMP-30", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005512": {"description": "PRONE domain", "go_ids": ["GO:0005085"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "PRONE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005513": {"description": "Late embryogenesis abundant protein, LEA_1 subgroup", "go_ids": ["GO:0009793"], "go_terms": ["GO:0009793:embryo development ending in seed dormancy:P"], "name": "LEA_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005514": {"description": "Chymotrypsin family Peptidase-S1", "go_ids": [], "go_terms": [], "name": "DUF316", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005515": {"description": "Vitelline membrane outer layer protein I (VOMI)", "go_ids": [], "go_terms": [], "name": "VOMI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005516": {"description": "Remorin, C-terminal", "go_ids": [], "go_terms": [], "name": "Remorin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005517": {"description": "Translation elongation factor EFG/EF2, domain IV", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "Transl_elong_EFG/EF2_IV", "pathway_ids": ["R-DME-5358493", "R-HSA-6798695", "R-SCE-8876725", "R-SPO-6798695", "R-HSA-8876725", "R-HSA-5419276", "R-RNO-5358493", "R-CEL-156902", "R-CEL-6798695", "R-SPO-72163", "R-SCE-6798695", "R-BTA-6798695", "R-BTA-5358493", "R-DRE-156902", "R-DME-156902", "R-SPO-156902", "R-SPO-5358493", "R-HSA-5336415", "R-RNO-5419276", "R-DRE-6798695", "R-HSA-72165", "R-HSA-5389840", "R-DDI-156902", "R-HSA-9918481", "R-BTA-8876725", "R-RNO-5389840", "R-DRE-5419276", "R-DRE-5358493", "R-DDI-6798695", "R-RNO-156902", "R-SCE-5358493", "R-CEL-5358493", "R-CEL-5389840", "R-MMU-72163", "R-DME-6798695", "R-HSA-156902", "R-CEL-8876725", "R-SPO-8876725", "R-DRE-5389840", "R-DDI-8876725", "R-MMU-156902", "R-MMU-8876725", "R-DME-8876725", "R-HSA-72163", "R-DRE-8876725", "R-MMU-5358493", "R-MMU-72165", "R-SCE-156902", "R-BTA-156902", "R-HSA-5358493", "R-RNO-8876725", "R-MMU-5419276", "R-MMU-6798695", "R-BTA-5419276", "R-DME-5389840", "R-DDI-5358493", "R-MMU-5389840", "R-RNO-6798695"], "pathways": ["R-DME-5358493:r:Synthesis of diphthamide-EEF2", 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activation of arylsulfatases"], "type": "Domain"}, "IPR005533": {"description": "AMOP domain", "go_ids": [], "go_terms": [], "name": "AMOP_dom", "pathway_ids": ["R-DME-977068", "R-HSA-5083632", "R-HSA-5083636", "R-MMU-913709", "R-HSA-977068", "R-HSA-5083625", "R-CEL-913709", "R-MMU-977068", "R-HSA-5621480", "R-DME-913709", "R-HSA-913709"], "pathways": ["R-DME-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5621480:r:Dectin-2 family", "R-DME-913709:r:O-linked glycosylation of mucins", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Domain"}, "IPR005534": {"description": "Curli production assembly/transport component CsgG", "go_ids": ["GO:0030288"], "go_terms": ["GO:0030288:outer membrane-bounded periplasmic space:C"], "name": "Curli_assmbl/transp-comp_CsgG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005535": {"description": "Cyclotide", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "Cyclotide", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005536": {"description": "Peptidase C25, Ig-like domain", "go_ids": ["GO:0006508", "GO:0008233"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008233:peptidase activity:F"], "name": "Peptidase_C25_Ig-like_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005537": {"description": "CRISPR type III-associated protein", "go_ids": [], "go_terms": [], "name": "RAMP_III_fam", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005538": {"description": "LrgA/CidA family", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "LrgA/CidA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005539": {"description": "ELK domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "ELK_dom", "pathway_ids": ["R-HSA-5576890", "R-HSA-380320", "R-HSA-5576893", "R-HSA-6802952", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR005540": {"description": "KNOX1", "go_ids": ["GO:0003677", "GO:0005634"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C"], "name": "KNOX1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005541": {"description": "KNOX2", "go_ids": ["GO:0003677", "GO:0005634"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C"], "name": "KNOX2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005542": {"description": "PBX, PBC domain", "go_ids": ["GO:0003700", "GO:0005634"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C"], "name": "PBX_PBC_dom", "pathway_ids": ["R-HSA-5617472", "R-HSA-452723", "R-HSA-9013508"], "pathways": ["R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription"], "type": "Domain"}, "IPR005543": {"description": "PASTA domain", "go_ids": [], "go_terms": [], "name": "PASTA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005545": {"description": "YCII-related", "go_ids": [], "go_terms": [], "name": "YCII", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005546": {"description": "Autotransporter beta-domain", "go_ids": [], "go_terms": [], "name": "Autotransporte_beta", "pathway_ids": ["R-HSA-9760173", "R-HSA-9927020"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-9927020:r:Heme assimilation"], "type": "Domain"}, "IPR005548": {"description": "Cell division protein FtsQ/DivIB, C-terminal", "go_ids": [], "go_terms": [], "name": "Cell_div_FtsQ/DivIB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005549": {"description": "Kinetochore protein Nuf2, N-terminal", "go_ids": ["GO:0031262", "GO:0000776"], "go_terms": ["GO:0031262:Ndc80 complex:C", "GO:0000776:kinetochore:C"], "name": "Kinetochore_Nuf2_N", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-2500257", "R-DRE-2500257", "R-MMU-2467813", "R-HSA-141444", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-RNO-5663220", "R-HSA-9648025", "R-HSA-68877", "R-RNO-9648025", "R-RNO-2467813", "R-DRE-5663220", "R-HSA-5663220", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Domain"}, "IPR005550": {"description": "Kinetochore protein Ndc80", "go_ids": ["GO:0031262", "GO:0051315"], "go_terms": ["GO:0031262:Ndc80 complex:C", "GO:0051315:attachment of mitotic spindle microtubules to kinetochore:P"], "name": "Kinetochore_Ndc80", "pathway_ids": ["R-MMU-2500257", "R-XTR-9648025", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-DRE-2500257", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-HSA-9648025", "R-XTR-68877", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-GGA-2500257", "R-GGA-141444", "R-XTR-141444", "R-HSA-68877", "R-GGA-9648025", "R-GGA-5663220", "R-HSA-5663220", "R-DRE-5663220", "R-GGA-2467813", "R-MMU-9648025", "R-XTR-2500257", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR005551": {"description": "Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase", "go_ids": ["GO:0051191"], "go_terms": ["GO:0051191:prosthetic group biosynthetic process:P"], "name": "CitX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005552": {"description": "Scramblase", "go_ids": ["GO:0017128", "GO:0017121"], "go_terms": ["GO:0017128:phospholipid scramblase activity:F", "GO:0017121:plasma membrane phospholipid scrambling:P"], "name": "Scramblase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005553": {"description": "Cytoadherence-linked asexual protein", "go_ids": ["GO:0020035"], "go_terms": ["GO:0020035:adhesion of symbiont to microvasculature:P"], "name": "CLAG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005554": {"description": "NOL6/Upt22", "go_ids": [], "go_terms": [], "name": "NOL6/Upt22", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR005555": {"description": "M-factor", "go_ids": ["GO:0000772"], "go_terms": ["GO:0000772:mating pheromone activity:F"], "name": "M-factor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005556": {"description": "Secreted beta-glucosidase SUN1-like domain", "go_ids": [], "go_terms": [], "name": "SUN1-like_dom", "pathway_ids": ["PWY-7529", "PWY-6848", "PWY-7134", "PWY-8435", "PWY-1921", "PWY-7133", "PWY-6784", "PWY-8436", "PWY-7091", "PWY-7074", "PWY-6527", "PWY-6717", "PWY-7647", "PWY-6972", "PWY-8366", "PWY-5976", "PWY-6821", "PWY-6735", "PWY-6906", "PWY-6855", "PWY-7491", "PWY-7057", "PWY-842", "PWY-862", "PWY-6737", "PWY-7445", "PWY-5821", "PWY-6749", "PWY-7056", "PWY-7256"], "pathways": ["PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6848:t:rutin degradation", "PWY-7134:t:rutin degradation (plants)", "PWY-8435:t:yeast mannan degradation", "PWY-1921:t:indole-3-acetate activation II", "PWY-7133:t:quercetin glucoside degradation (Allium)", "PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)", "PWY-8436:t:mammalian high-mannose N-glycan degradation", "PWY-7091:t:linustatin bioactivation", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-6527:t:stachyose degradation", "PWY-6717:t:(1,4)-beta-D-xylan degradation", "PWY-7647:t:ulvan degradation", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8366:t:septacidin biosynthesis", "PWY-5976:t:dhurrin degradation", "PWY-6821:t:kappa-carrageenan degradation", "PWY-6735:t:starch degradation IV", "PWY-6906:t:chitin derivatives degradation", "PWY-6855:t:chitin degradation I (archaea)", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7057:t:cichoriin interconversion", "PWY-842:t:starch degradation I", "PWY-862:t:fructan degradation", "PWY-6737:t:starch degradation V", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-5821:t:dalcochinin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7056:t:daphnin interconversion", "PWY-7256:t:cyanidin diglucoside biosynthesis (acyl-glucose dependent)"], "type": "Domain"}, "IPR005557": {"description": "Colicin immunity protein", "go_ids": ["GO:0015643", "GO:0030153"], "go_terms": ["GO:0015643:toxic substance binding:F", "GO:0030153:bacteriocin immunity:P"], "name": "Colicin_im", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005558": {"description": "Crustacean neurohormone H", "go_ids": [], "go_terms": [], "name": "Crust_neurhormone_H", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005559": {"description": "CG-1 DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "CG-1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005560": {"description": "Uncharacterized cysteine-rich protein YhjQ/Copper storage protein-like", "go_ids": [], "go_terms": [], "name": "Csp_YhjQ", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR005561": {"description": "ANTAR domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "ANTAR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005562": {"description": "SpoVA", "go_ids": [], "go_terms": [], "name": "SpoVA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005563": {"description": "Assembly protein", "go_ids": ["GO:0039666"], "go_terms": ["GO:0039666:virion attachment to host cell pilus:P"], "name": "A_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005564": {"description": "Major capsid protein GpE", "go_ids": [], "go_terms": [], "name": "Major_capsid_GpE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005565": {"description": "Haemolysin activator HlyB, C-terminal", "go_ids": [], "go_terms": [], "name": "Hemolysn_activator_HlyB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005566": {"description": "Hydrophobic abundant protein (HAP)", "go_ids": [], "go_terms": [], "name": "HAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005567": {"description": "Fushi tarazu, N-terminal", "go_ids": [], "go_terms": [], "name": "FTZ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005568": {"description": "Large ribosomal subunit protein uL6, N-terminal", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uL6_N", "pathway_ids": ["R-HSA-9954716", "R-BTA-975957", "R-MMU-72689", "R-HSA-9010553", "R-HSA-156827", "R-RNO-72689", "R-RNO-1799339", "R-MMU-9954709", "R-BTA-72689", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-BTA-72706", "R-RNO-9954716", "R-HSA-9954709", "R-MMU-975956", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-BTA-9954716", "R-BTA-6791226", "R-MMU-975957", "R-HSA-156902", "R-HSA-72706", "R-HSA-72689", "R-HSA-72764", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-RNO-6791226", "R-MMU-1799339", "R-HSA-975957", "R-HSA-6791226", "R-RNO-975956", "R-BTA-975956", "R-RNO-9954709", "R-BTA-9954709", "R-HSA-9954714", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": 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"R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon 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"R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6782135:r:Dual incision in TC-NER", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DRE-6803529:r:FGFR2 alternative splicing", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-9770562:r:mRNA Polyadenylation", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-167172:r:Transcription of the HIV genome", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DRE-6782135:r:Dual incision in TC-NER", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-72086:r:mRNA Capping", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-DRE-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DRE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER"], "type": "Domain"}, "IPR005578": {"description": "Yif1 family", "go_ids": ["GO:0005789", "GO:0006888"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P"], "name": "Yif1_fam", "pathway_ids": ["R-HSA-381038"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes"], "type": "Family"}, "IPR005579": {"description": "Cgr1-like", "go_ids": [], "go_terms": [], "name": "Cgr1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005580": {"description": "DEAD box helicase DbpA/CsdA, RNA-binding domain", "go_ids": [], "go_terms": [], "name": "DbpA/CsdA_RNA-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005582": {"description": "Chromosome partition protein MukF", "go_ids": ["GO:0005509", "GO:0006260", "GO:0007059"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0006260:DNA replication:P", "GO:0007059:chromosome segregation:P"], "name": "Chromosome_partition_MukF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005583": {"description": "DNA-binding and peroxide stress resistance protein YaaA", "go_ids": [], "go_terms": [], "name": "YaaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005584": {"description": "DNA gyrase inhibitor YacG", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "DNA_gyrase_inhibitor_YacG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005585": {"description": "Protein of unknown function DUF327", "go_ids": [], "go_terms": [], "name": "DUF327", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005586": {"description": "ABC-type transport auxiliary lipoprotein component", "go_ids": [], "go_terms": [], "name": "ABC_trans_aux", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005587": {"description": "Uncharacterised protein family UPF0304, YfbU", "go_ids": [], "go_terms": [], "name": "UPF0304_YfbU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005588": {"description": "MucB/RseB", "go_ids": [], "go_terms": [], "name": "MucB_RseB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005589": {"description": "Alternative ribosome-rescue factor A", "go_ids": ["GO:0072344"], "go_terms": ["GO:0072344:rescue of stalled cytosolic ribosome:P"], "name": "ArfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005590": {"description": "Protein of unknown function DUF333", "go_ids": [], "go_terms": [], "name": "DUF333", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005591": {"description": "Nitrate reductase cytochrome c-type subunit NapB", "go_ids": ["GO:0009061"], "go_terms": ["GO:0009061:anaerobic respiration:P"], "name": "NapB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005592": {"description": "Mono-/di-acylglycerol lipase, N-terminal", "go_ids": ["GO:0016042"], "go_terms": ["GO:0016042:lipid catabolic process:P"], "name": "Mono/diacylglycerol_lipase_N", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Domain"}, "IPR005593": {"description": "Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase", "go_ids": ["GO:0005975", "GO:0016832"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016832:aldehyde-lyase activity:F"], "name": "Xul5P/Fru6P_PKetolase", "pathway_ids": ["PWY-7089", "PWY-7085"], "pathways": ["PWY-7089:t:taxiphyllin bioactivation", "PWY-7085:t:triethylamine degradation"], "type": "Family"}, "IPR005594": {"description": "Trimeric autotransporter adhesin YadA-like, C-terminal membrane anchor domain", "go_ids": [], "go_terms": [], "name": "YadA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005595": {"description": "Translocon-associated protein (TRAP), alpha subunit", "go_ids": ["GO:0005789"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C"], "name": "TRAP_alpha", "pathway_ids": ["R-HSA-1799339", "R-HSA-381038"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-381038:r:XBP1(S) activates chaperone genes"], "type": "Family"}, "IPR005597": {"description": "Satellite tobacco necrosis virus coat protein-like", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Satellite_CP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005598": {"description": "ATP synthase protein I", "go_ids": [], "go_terms": [], "name": "ATP_synth_I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005599": {"description": "GPI mannosyltransferase", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "GPI_mannosylTrfase", "pathway_ids": ["PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-SCE-446193", "R-SPO-162710", "R-MMU-446193", "R-DME-446193", "R-HSA-162710", "R-HSA-4720454", "R-CEL-446193", "R-DME-162710", "R-SCE-162710", "R-MMU-162710", "R-BTA-162710", "R-SPO-446193", "R-HSA-4720489", "R-DRE-162710", "R-HSA-446193", "PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859"], "pathways": ["PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-SCE-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DME-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-4720454:r:Defective ALG9 causes CDG-1l", "R-CEL-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DME-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-BTA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-4720489:r:Defective ALG12 causes CDG-1g", "R-DRE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation"], "type": "Family"}, "IPR005600": {"description": "Gal4 dimerisation domain", "go_ids": [], "go_terms": [], "name": "Gal4_dimer_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005601": {"description": "Tail fibre protein p36", "go_ids": [], "go_terms": [], "name": "Tail_fibre_p36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005602": {"description": "Uncharacterized protein ORFD", "go_ids": [], "go_terms": [], "name": "ORFD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005603": {"description": "Coronavirus nonstructural protein NS4", "go_ids": [], "go_terms": [], "name": "Corona_NS4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005604": {"description": "Bacteriophage T7 tail fibre protein-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Phage_T7_tail_fibre-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005605": {"description": "Sporulation-specific protein Spo7", "go_ids": ["GO:0019888"], "go_terms": ["GO:0019888:protein phosphatase regulator activity:F"], "name": "Spo7", "pathway_ids": ["R-SPO-4419969"], "pathways": ["R-SPO-4419969:r:Depolymerization of the Nuclear Lamina"], "type": "Family"}, "IPR005606": {"description": "Sec20", "go_ids": ["GO:0005484", "GO:0006890"], "go_terms": ["GO:0005484:SNAP receptor activity:F", "GO:0006890:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum:P"], "name": "Sec20", "pathway_ids": ["R-HSA-6811434", "R-RNO-6811434", "R-SCE-6811434", "R-SPO-6811434", "R-MMU-6811434"], "pathways": ["R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR005607": {"description": "BSD domain", "go_ids": [], "go_terms": [], "name": "BSD_dom", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DME-6781823", "R-DME-76042", "R-MMU-113418", "R-HSA-427413", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-SPO-5696395", "R-SPO-76042", "R-HSA-167246", "R-HSA-73776", "R-MMU-5696395", "R-DME-72086", "R-DDI-674695", "R-HSA-75953", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-DME-75953", "R-MMU-73779", 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dehydrogenase", "go_ids": [], "go_terms": [], "name": "SDH", "pathway_ids": ["R-DME-9854311", "R-RNO-9854311", "R-HSA-9854311", "R-BTA-9854311", "R-MMU-9854311", "R-CEL-9854311", "R-SPO-9854311", "R-DDI-9854311", "R-DRE-9854311", "R-SCE-9854311"], "pathways": ["R-DME-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Family"}, "IPR005632": {"description": "Chaperone protein Skp", "go_ids": [], "go_terms": [], "name": "Chaperone_Skp", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR005633": {"description": "Large ribosomal subunit protein uL23, N-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL23_N", "pathway_ids": ["R-CEL-72689", "R-DDI-975956", "R-HSA-9954716", "R-CEL-975957", "R-SCE-72706", "R-SPO-9954714", "R-MMU-72689", "R-HSA-9010553", "R-RNO-72706", "R-SPO-975957", "R-SCE-9954709", "R-HSA-156827", "R-RNO-72689", "R-RNO-1799339", "R-MMU-9954709", "R-DDI-72689", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-SCE-975957", "R-RNO-9954716", "R-DDI-9954714", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-CEL-72706", "R-DDI-9954709", "R-CEL-9954716", "R-SCE-72689", "R-CEL-9954714", "R-MMU-975956", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-SCE-156827", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-CEL-9954709", "R-SCE-975956", "R-CEL-1799339", "R-MMU-975957", "R-HSA-156902", "R-HSA-72706", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-CEL-156827", "R-RNO-6791226", "R-MMU-1799339", "R-HSA-975957", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-HSA-9954714", "R-DDI-156827", "R-SPO-72689", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-HSA-192823:r:Viral mRNA Translation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR005634": {"description": "Male specific sperm protein", "go_ids": [], "go_terms": [], "name": "MSSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005635": {"description": "Inner centromere protein, ARK-binding domain", "go_ids": [], "go_terms": [], "name": "Inner_centromere_prot_ARK-bd", "pathway_ids": ["R-MMU-2500257", "R-XTR-4615885", "R-XTR-9648025", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-HSA-9648025", "R-XTR-68877", "R-MMU-68877", "R-MMU-4615885", "R-XTR-141444", "R-HSA-68877", "R-HSA-5663220", "R-HSA-4615885", "R-MMU-9648025", "R-XTR-2500257", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR005636": {"description": "DTW", "go_ids": [], "go_terms": [], "name": "DTW", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005637": {"description": "TAP C-terminal (TAP-C) domain", "go_ids": ["GO:0005634", "GO:0051028"], "go_terms": ["GO:0005634:nucleus:C", "GO:0051028:mRNA transport:P"], "name": "TAP_C_dom", "pathway_ids": ["R-CEL-159231", "R-BTA-159230", "R-SPO-159236", "R-SPO-159227", "R-SPO-159231", "R-CEL-159227", "R-DME-159236", "R-DME-159231", "R-DME-159227", "R-RNO-159227", "R-BTA-159227", "R-MMU-159236", "R-MMU-159230", "R-DME-159230", "R-HSA-159230", "R-HSA-159231", "R-RNO-159230", "R-MMU-159227", "R-HSA-159227", "R-CEL-159230", "R-RNO-159231", "R-RNO-159236", "R-BTA-159236", "R-BTA-159231", "R-HSA-159236", "R-MMU-159231", "R-CEL-159236"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR005638": {"description": "Pesticidal crystal protein, domain III", "go_ids": ["GO:0090729"], "go_terms": ["GO:0090729:toxin activity:F"], "name": "Pest_crys_dom-III", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005639": {"description": "Pesticidal crystal protein, domain I", "go_ids": ["GO:0001907", "GO:0090729"], "go_terms": ["GO:0001907:symbiont-mediated killing of host cell:P", "GO:0090729:toxin activity:F"], "name": "Pest_crys_dom_I", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005641": {"description": "Hexon-associated protein IX", "go_ids": ["GO:0031423", "GO:0019028"], "go_terms": ["GO:0031423:hexon binding:F", "GO:0019028:viral capsid:C"], "name": "Hexon_assoc_IX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005642": {"description": "Lysine exporter LysO", "go_ids": ["GO:0015661", "GO:1903401"], "go_terms": ["GO:0015661:L-lysine efflux transmembrane transporter activity:F", "GO:1903401:L-lysine transmembrane transport:P"], "name": "LysO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005643": {"description": "Jun-like transcription factor", "go_ids": [], "go_terms": [], "name": "JNK", "pathway_ids": ["R-HSA-2559580", "R-HSA-2871796", "R-DME-209425", "R-HSA-8862803", "R-HSA-2559582", "R-HSA-6796648", "R-HSA-6785807", "R-HSA-9673324", "R-RNO-9018519", "R-MMU-2559580", "R-HSA-1912408", "R-MMU-2871796", "R-HSA-2173796", "R-HSA-450341", "R-HSA-9725371", "R-HSA-9909649", "R-RNO-2559580", "R-HSA-5687128", "R-DME-209409", "R-HSA-8943724", "R-MMU-450341", "R-DME-209394", "R-HSA-9031628", "R-RNO-450341", "R-GGA-437986", "R-HSA-9725370", "R-HSA-9018519", "R-HSA-5617472", "R-RNO-2871796"], "pathways": ["R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-DME-209425:r:Transcriptional activtion by AP-1 transcription factor", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-209409:r:Formation of the nuclear AP-1 transcription factor 'scaffolding complex'", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-450341:r:Activation of the AP-1 family of transcription factors", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-HSA-9031628:r:NGF-stimulated transcription", "R-RNO-450341:r:Activation of the AP-1 family of transcription factors", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-2871796:r:FCERI mediated MAPK activation"], "type": "Domain"}, "IPR005644": {"description": "NolW-like", "go_ids": [], "go_terms": [], "name": "NolW-like", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR005645": {"description": "Serine hydrolase domain", "go_ids": [], "go_terms": [], "name": "FSH-like_dom", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741", "R-SPO-196757"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis", "R-SPO-196757:r:Metabolism of folate and pterines"], "type": "Domain"}, "IPR005646": {"description": "Flagellar assembly protein A", "go_ids": [], "go_terms": [], "name": "FapA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005647": {"description": "Meiotic nuclear division protein 1", "go_ids": ["GO:0007131", "GO:0003690"], "go_terms": ["GO:0007131:reciprocal meiotic recombination:P", "GO:0003690:double-stranded DNA binding:F"], "name": "Mnd1", "pathway_ids": ["R-HSA-912446"], "pathways": ["R-HSA-912446:r:Meiotic recombination"], "type": "Family"}, "IPR005648": {"description": "Flagellar hook capping protein", "go_ids": [], "go_terms": [], "name": "FlgD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR005649": {"description": "Chorion 2", "go_ids": ["GO:0007275", "GO:0042600"], "go_terms": ["GO:0007275:multicellular organism development:P", "GO:0042600:egg chorion:C"], "name": "Chorion_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005650": {"description": "BlaI transcriptional regulatory family", "go_ids": ["GO:0003677", "GO:0045892"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "BlaI_family", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005651": {"description": "Trm112-like", "go_ids": [], "go_terms": [], "name": "Trm112-like", "pathway_ids": ["R-CEL-156581", "R-MMU-6799198", "R-SPO-72764", "R-HSA-6799198", "R-SCE-156581", "R-DME-156581", "R-DDI-72764", "R-CEL-72764", "R-HSA-72764", "R-MMU-156581", "R-HSA-6790901", "R-SPO-156581", "R-DME-72764", "R-BTA-156581", "R-HSA-6782315", "R-BTA-72764", "R-HSA-156581", "R-DDI-156581", "R-SCE-72764", "R-MMU-72764"], "pathways": ["R-CEL-156581:r:Methylation", "R-MMU-6799198:r:Complex I biogenesis", "R-SPO-72764:r:Eukaryotic Translation Termination", "R-HSA-6799198:r:Complex I biogenesis", "R-SCE-156581:r:Methylation", "R-DME-156581:r:Methylation", "R-DDI-72764:r:Eukaryotic Translation Termination", "R-CEL-72764:r:Eukaryotic Translation Termination", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-MMU-156581:r:Methylation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-SPO-156581:r:Methylation", "R-DME-72764:r:Eukaryotic Translation Termination", "R-BTA-156581:r:Methylation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-BTA-72764:r:Eukaryotic Translation Termination", "R-HSA-156581:r:Methylation", "R-DDI-156581:r:Methylation", "R-SCE-72764:r:Eukaryotic Translation Termination", "R-MMU-72764:r:Eukaryotic Translation Termination"], "type": "Family"}, "IPR005652": {"description": "Photosynthetic reaction centre, H 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["GO:0003852:2-isopropylmalate synthase activity:F", "GO:0009098:L-leucine biosynthetic process:P"], "name": "IPM_Synthase", "pathway_ids": ["PWY-6871"], "pathways": ["PWY-6871:t:3-methylbutanol biosynthesis (engineered)"], "type": "Family"}, "IPR005669": {"description": "Thiosulphate/Sulfate-binding protein", "go_ids": ["GO:1902358", "GO:0140104"], "go_terms": ["GO:1902358:sulfate transmembrane transport:P", "GO:0140104:molecular carrier activity:F"], "name": "Thiosulph/SO4-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005670": {"description": "Phosphate import ATP-binding protein PstB-like", "go_ids": ["GO:0005315", "GO:0016020", "GO:0035435"], "go_terms": ["GO:0005315:phosphate transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0035435:phosphate ion transmembrane transport:P"], "name": "PstB-like", "pathway_ids": ["PWY-4621", "PWY-8264"], "pathways": ["PWY-4621:t:arsenic detoxification (bacteria)", "PWY-8264:t:arsenate detoxification I"], "type": "Family"}, "IPR005671": {"description": "2-isopropylmalate synthase, bacterial-type", "go_ids": ["GO:0003852", "GO:0009098"], "go_terms": ["GO:0003852:2-isopropylmalate synthase activity:F", "GO:0009098:L-leucine biosynthetic process:P"], "name": "LeuA_bact_synth", "pathway_ids": ["PWY-6871"], "pathways": ["PWY-6871:t:3-methylbutanol biosynthesis (engineered)"], "type": "Family"}, "IPR005672": {"description": "Phosphate transport system permease protein PstA", "go_ids": ["GO:0005315", "GO:0035435", "GO:0005886"], "go_terms": ["GO:0005315:phosphate transmembrane transporter activity:F", "GO:0035435:phosphate ion transmembrane transport:P", "GO:0005886:plasma membrane:C"], "name": "Phosphate_PstA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005673": {"description": "Phosphate ABC transporter, substrate-binding protein PstS", "go_ids": ["GO:0043190", "GO:0042301", "GO:0035435"], "go_terms": ["GO:0043190:ATP-binding cassette (ABC) transporter complex:C", "GO:0042301:phosphate ion binding:F", "GO:0035435:phosphate ion transmembrane transport:P"], "name": "ABC_phos-bd_PstS", "pathway_ids": ["R-HSA-9637628"], "pathways": ["R-HSA-9637628:r:Modulation by Mtb of host immune system"], "type": "Family"}, "IPR005674": {"description": "CocE/Serine esterase", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "CocE/Ser_esterase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005675": {"description": "Citramalate synthase", "go_ids": ["GO:0019752", "GO:0046912"], "go_terms": ["GO:0019752:carboxylic acid metabolic process:P", "GO:0046912:acyltransferase activity, acyl groups converted into alkyl on transfer:F"], "name": "Citramal_synthase", "pathway_ids": ["PWY-5101"], "pathways": ["PWY-5101:t:L-isoleucine biosynthesis II"], "type": "Family"}, "IPR005676": {"description": "Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking", "go_ids": ["GO:0050661"], "go_terms": ["GO:0050661:NADP binding:F"], "name": "Asp_semi-ald_DH_pep-lack", "pathway_ids": ["PWY-7977", "PWY-6562", "PWY-2942", "PWY-8088", "PWY-8296", "PWY-6559", "PWY-6160", "PWY-5097", "PWY-7153", "PWY-8179", "PWY-2941"], "pathways": ["PWY-7977:t:L-methionine biosynthesis IV", "PWY-6562:t:norspermidine biosynthesis", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8088:t:dipicolinate biosynthesis", "PWY-8296:t:cremeomycin biosynthesis", "PWY-6559:t:spermidine biosynthesis II", "PWY-6160:t:3-dehydroquinate biosynthesis II (archaea)", "PWY-5097:t:L-lysine biosynthesis VI", "PWY-7153:t:grixazone biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Family"}, "IPR005677": {"description": "Fumarate hydratase, class II", "go_ids": ["GO:0004333", "GO:0006106"], "go_terms": ["GO:0004333:fumarate hydratase activity:F", "GO:0006106:fumarate metabolic process:P"], "name": "Fum_hydII", "pathway_ids": ["PWY-8086", "PWY-7254", "PWY-6728", "PWY-5913", "PWY-7384", "PWY-561", "PWY-5690", 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"GO:0016881:acid-amino acid ligase activity:F", "GO:0051301:cell division:P"], "name": "UDP-N-AcMur-Glu-dNH2Pim_ligase", "pathway_ids": ["PWY-7953", "PWY-6387"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)"], "type": "Family"}, "IPR005762": {"description": "UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD", "go_ids": ["GO:0005524", "GO:0005737", "GO:0008360", "GO:0008764", "GO:0051301"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0008360:regulation of cell shape:P", "GO:0008764:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity:F", "GO:0051301:cell division:P"], "name": "MurD", "pathway_ids": ["PWY-6387", "PWY-6386"], "pathways": ["PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II 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"R-DME-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-SSC-5578775:r:Ion homeostasis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SSC-936837:r:Ion transport by P-type ATPases", "R-CFA-936837:r:Ion transport by P-type ATPases", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-CFA-5578775:r:Ion homeostasis", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-SSC-418359:r:Reduction of cytosolic Ca++ levels", "R-CFA-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-BTA-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Family"}, "IPR005783": {"description": "Methylmalonyl-CoA decarboxylase, alpha subunit", "go_ids": [], "go_terms": [], "name": "MemalonylCoA_decase_suA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005784": {"description": "D-amino acid aminotransferase", "go_ids": ["GO:0008483", "GO:0046416", "GO:0030170"], "go_terms": ["GO:0008483:transaminase activity:F", "GO:0046416:D-amino acid metabolic process:P", "GO:0030170:pyridoxal phosphate binding:F"], "name": "D_amino_transT", "pathway_ids": ["PWY-8448"], "pathways": ["PWY-8448:t:D-alanine degradation"], "type": "Family"}, "IPR005785": {"description": "Branched-chain amino acid aminotransferase I", "go_ids": ["GO:0004084", "GO:0009081"], "go_terms": ["GO:0004084:branched-chain-amino-acid:2-oxoglutarate transaminase activity:F", "GO:0009081:branched-chain amino acid metabolic process:P"], "name": "B_amino_transI", "pathway_ids": ["PWY-8175", "PWY-8174", "PWY-8185", "PWY-5101", "PWY-5103", "PWY-5078", "PWY-5076", "PWY-5108", "PWY-8183", "PWY-5104", "PWY-8184", "PWY-5057", "PWY-7767", "PWY-8173"], "pathways": ["PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8185:t:L-leucine degradation V (oxidative Stickland reaction)", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-5103:t:L-isoleucine biosynthesis III", "PWY-5078:t:L-isoleucine degradation II", "PWY-5076:t:L-leucine degradation III", "PWY-5108:t:L-isoleucine biosynthesis V", "PWY-8183:t:L-valine degradation III (oxidative Stickland reaction)", "PWY-5104:t:L-isoleucine biosynthesis IV", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-5057:t:L-valine degradation II", "PWY-7767:t:L-leucine degradation IV (reductive Stickland reaction)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis"], "type": "Family"}, "IPR005786": {"description": "Branched-chain amino acid aminotransferase II", "go_ids": ["GO:0004084", "GO:0009081"], "go_terms": ["GO:0004084:branched-chain-amino-acid:2-oxoglutarate transaminase activity:F", "GO:0009081:branched-chain amino acid metabolic process:P"], "name": "B_amino_transII", "pathway_ids": ["PWY-8175", "PWY-8174", "PWY-8185", "PWY-5101", "PWY-5103", "PWY-5078", "PWY-5076", "PWY-5108", "PWY-8183", "PWY-5104", "PWY-8184", "PWY-5057", "PWY-7767", "PWY-8173", "R-BTA-70895", "R-SPO-70895", "R-MMU-70895", "R-CEL-70895", "R-DDI-70895", "R-HSA-70895", "R-SCE-70895", "R-RNO-70895"], "pathways": ["PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8185:t:L-leucine degradation V (oxidative Stickland reaction)", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-5103:t:L-isoleucine biosynthesis III", "PWY-5078:t:L-isoleucine degradation II", "PWY-5076:t:L-leucine degradation III", "PWY-5108:t:L-isoleucine biosynthesis V", "PWY-8183:t:L-valine degradation III (oxidative Stickland reaction)", "PWY-5104:t:L-isoleucine biosynthesis IV", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-5057:t:L-valine degradation II", "PWY-7767:t:L-leucine degradation IV (reductive Stickland reaction)", 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"R-HSA-5368286:r:Mitochondrial translation initiation", "R-HSA-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines"], "type": "Domain"}, "IPR005794": {"description": "Methionyl-tRNA formyltransferase", "go_ids": ["GO:0004479", "GO:0071951"], "go_terms": ["GO:0004479:methionyl-tRNA formyltransferase activity:F", "GO:0071951:conversion of methionyl-tRNA to N-formyl-methionyl-tRNA:P"], "name": "Fmt", "pathway_ids": ["R-HSA-5368286"], "pathways": ["R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Family"}, "IPR005797": {"description": "Cytochrome b/b6, N-terminal domain", "go_ids": ["GO:0009055", "GO:0016020", "GO:0016491"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0016020:membrane:C", "GO:0016491:oxidoreductase activity:F"], "name": "Cyt_b/b6_N", "pathway_ids": ["R-HSA-9865881", "R-HSA-5419276", "R-DDI-611105", "R-DRE-611105", "R-DRE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SCE-9865878", 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"R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-BTA-9865881:r:Complex III assembly", "R-RNO-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-CEL-5419276:r:Mitochondrial translation termination", "R-SCE-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR005798": {"description": "Cytochrome b/b6, C-terminal", "go_ids": ["GO:0009055", "GO:0016020", "GO:0016491"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0016020:membrane:C", "GO:0016491:oxidoreductase activity:F"], "name": "Cyt_b/b6_C", "pathway_ids": ["R-HSA-9865881", "R-HSA-5419276", "R-DDI-611105", "R-DRE-611105", "R-DRE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-RNO-5419276", "R-CEL-611105", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-BTA-9865881", "R-RNO-9865881", "R-SPO-611105", "R-CEL-5419276", "R-SCE-611105", "R-DRE-5419276", "R-BTA-611105", "R-DME-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DDI-611105:r:Respiratory electron transport", "R-DRE-611105:r:Respiratory electron transport", "R-DRE-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-5419276:r:Mitochondrial translation termination", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-BTA-9865881:r:Complex III assembly", "R-RNO-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-CEL-5419276:r:Mitochondrial translation termination", "R-SCE-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR005801": {"description": "ADC synthase", "go_ids": ["GO:0009058"], "go_terms": ["GO:0009058:biosynthetic process:P"], "name": "ADC_synthase", "pathway_ids": ["PWY-6661", "PWY-5958"], "pathways": ["PWY-6661:t:4-hydroxy-2(1H)-quinolone biosynthesis", "PWY-5958:t:acridone alkaloid biosynthesis"], "type": "Homologous_superfamily"}, "IPR005802": {"description": "Aminodeoxychorismate synthase, component I", "go_ids": ["GO:0009396"], "go_terms": ["GO:0009396:folic acid-containing compound biosynthetic process:P"], "name": "ADC_synth_comp_1", "pathway_ids": ["PWY-8032", "PWY-6543"], "pathways": ["PWY-8032:t:chloramphenicol biosynthesis", "PWY-6543:t:4-aminobenzoate biosynthesis I"], "type": "Family"}, "IPR005804": {"description": "Fatty acid desaturase domain", "go_ids": ["GO:0006629"], "go_terms": ["GO:0006629:lipid metabolic process:P"], "name": "FA_desaturase_dom", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-HSA-1989781", "R-SPO-6798695", "R-RNO-2046105", "R-DRE-2046106", "R-DRE-2046105", "R-CEL-6798695", "R-RNO-2046106", "R-HSA-9619665", "R-BTA-6798695", "R-HSA-2046105", "R-DME-1660661", "R-GGA-1660661", "R-CEL-2046106", "R-CEL-2046105", "R-CEL-1660661", "R-GGA-433584", "R-MMU-1660661", "R-MMU-2046106", "R-DME-6798695", "R-SPO-75105", "R-BTA-2046106", "R-HSA-1660661", "R-XTR-6798695", "R-GGA-6798695", "R-BTA-1660661", "R-BTA-75105", "R-XTR-1660661", "R-HSA-75105", "R-RNO-1660661", "R-MMU-6798695", "R-HSA-2046106", "R-MMU-2046105", "R-BTA-2046105", "R-SCE-75105"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1989781:r:PPARA activates gene expression", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-DRE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DRE-2046105:r:Linoleic acid (LA) metabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-GGA-1660661:r:Sphingolipid de novo biosynthesis", "R-CEL-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-CEL-2046105:r:Linoleic acid (LA) metabolism", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-GGA-433584:r:Sphingolipid metabolism", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-XTR-6798695:r:Neutrophil degranulation", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-XTR-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-BTA-2046105:r:Linoleic acid (LA) metabolism", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR005807": {"description": "SecE subunit of protein translocation complex, bacterial-like", "go_ids": ["GO:0009306", "GO:0016020", "GO:0008320"], "go_terms": ["GO:0009306:protein secretion:P", "GO:0016020:membrane:C", "GO:0008320:transmembrane protein transporter activity:F"], "name": "SecE_bac", "pathway_ids": ["R-HSA-9760173", "R-HSA-1222387"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Family"}, "IPR005809": {"description": "Succinate--CoA ligase-like, beta subunit", "go_ids": ["GO:0006099"], "go_terms": ["GO:0006099:tricarboxylic acid cycle:P"], "name": "Succ_CoA_ligase-like_bsu", "pathway_ids": ["PWY-8354", "PWY-8347", "PWY-6728", "PWY-7384", "PWY-5690", "PWY-5537", "PWY-5538", "PWY-5392", "PWY-6969", "R-MMU-9837999", "R-SPO-71403", "R-CEL-9837999", "R-CEL-71403", "R-MMU-71403", "R-BTA-9837999", "R-BTA-71403", "R-SCE-71403", "R-DDI-71403", "R-HSA-9837999", "R-HSA-71403"], "pathways": ["PWY-8354:t:adipate degradation", "PWY-8347:t:adipate biosynthesis", "PWY-6728:t:methylaspartate cycle", "PWY-7384:t:anaerobic energy 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"CoA_lig_alpha", "pathway_ids": ["PWY-8354", "PWY-8347", "PWY-6728", "PWY-7384", "PWY-5690", "PWY-5537", "PWY-5538", "PWY-5392", "PWY-6969", "R-SPO-71403", "R-SSC-71403", "R-CEL-71403", "R-MMU-71403", "R-SCE-71403", "R-DME-71403", "R-DDI-71403", "R-RNO-71403", "R-HSA-71403"], "pathways": ["PWY-8354:t:adipate degradation", "PWY-8347:t:adipate biosynthesis", "PWY-6728:t:methylaspartate cycle", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5537:t:pyruvate fermentation to acetate V", "PWY-5538:t:pyruvate fermentation to acetate VI", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Family"}, "IPR005811": {"description": "ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "SUCC_ACL_C", "pathway_ids": ["PWY-8354", "PWY-8347", "PWY-6728", "PWY-7384", "PWY-5690", "PWY-5537", "PWY-5538", "PWY-5392", "PWY-6969", "R-HSA-6798695", "R-HSA-163765", "R-DDI-6798695", "R-SPO-6798695", "R-MMU-9837999", "R-CEL-9837999", "R-DDI-75105", "R-BTA-71403", "R-CEL-6798695", "R-SPO-75105", "R-BTA-6798695", "R-RNO-75105", "R-MMU-75105", "R-BTA-75105", "R-SPO-71403", "R-SSC-71403", "R-CEL-71403", "R-MMU-71403", "R-BTA-9837999", "R-SCE-71403", "R-HSA-75105", "R-MMU-6798695", "R-DME-71403", "R-DDI-71403", "R-HSA-9837999", "R-RNO-71403", "R-RNO-6798695", "R-HSA-71403", "R-CEL-75105"], "pathways": ["PWY-8354:t:adipate degradation", "PWY-8347:t:adipate 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"R-HSA-71064", "R-CEL-8964539", "R-MMU-389661", "R-DRE-1483213", "R-DME-71064", "R-SPO-916853", "R-PFA-8964539", "R-HSA-1442490", "R-SSC-916853", "R-CEL-1483213", "R-MMU-71064", "R-MMU-8964539", "R-SPO-71064", "R-RNO-389661", "R-MMU-1483213", "R-HSA-73621", "R-HSA-389661", "R-DME-1483213", "R-RNO-916853", "R-HSA-8964539", "R-DME-8964539", "R-SPO-8964539", "R-HSA-916853", "R-BTA-1483213", "R-CEL-916853", "R-DME-1442490", "R-SPO-1483213", "R-SCE-8964539", "R-CEL-1442490", "R-MMU-1442490"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "R-DDI-8964539:r:Glutamate and glutamine metabolism", "R-SCE-916853:r:Degradation of GABA", "R-CEL-71064:r:Lysine catabolism", "R-MMU-916853:r:Degradation of GABA", "R-SPO-1442490:r:Collagen degradation", "R-DDI-916853:r:Degradation of GABA", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-HSA-1483213:r:Synthesis of PE", "R-HSA-71064:r:Lysine catabolism", "R-CEL-8964539:r:Glutamate and glutamine metabolism", 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toxin type F (botF)", "R-MMU-189200:r:Cellular hexose transport", "R-RNO-189200:r:Cellular hexose transport", "R-MMU-5653890:r:Lactose synthesis", "R-MMU-442660:r:SLC-mediated transport of neurotransmitters", "R-RNO-200425:r:Carnitine shuttle", "R-MMU-8981373:r:Intestinal hexose absorption", "R-RNO-112311:r:Neurotransmitter clearance", "R-CEL-112311:r:Neurotransmitter clearance", "R-DRE-561048:r:Organic anion transport by SLC22 transporters", "R-MMU-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-9793528:r:Ciprofloxacin ADME", "R-HSA-5619043:r:Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)", "R-HSA-5250968:r:Toxicity of botulinum toxin type A (botA)", "R-HSA-8981373:r:Intestinal hexose absorption", "R-RNO-429593:r:Inositol transporters", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-MMU-112311:r:Neurotransmitter clearance", "R-SSC-5653890:r:Lactose synthesis", "R-HSA-917937:r:Iron uptake and 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["PWY-6936:t:seleno-amino acid biosynthesis (plants)", "R-MTU-936654:r:Cysteine synthesis from O-phosphoserine", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Family"}, "IPR005857": {"description": "Cystathionine beta-synthase", "go_ids": ["GO:0019344", "GO:0004122", "GO:0005737"], "go_terms": ["GO:0019344:L-cysteine biosynthetic process:P", "GO:0004122:cystathionine beta-synthase activity:F", "GO:0005737:cytoplasm:C"], "name": "Cysta_beta_synth", "pathway_ids": ["PWY-8359", "PWY-801", "R-SCE-1614603", "R-DDI-1614603", "R-MMU-1614603", "R-HSA-2408508", "R-HSA-1614603", "R-RNO-1614603"], "pathways": ["PWY-8359:t:taurine biosynthesis III", "PWY-801:t:homocysteine and cysteine interconversion", "R-SCE-1614603:r:Cysteine formation from homocysteine", "R-DDI-1614603:r:Cysteine formation from homocysteine", "R-MMU-1614603:r:Cysteine formation from homocysteine", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-HSA-1614603:r:Cysteine formation from 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"GO:0009236:cobalamin biosynthetic process:P"], "name": "CobD", "pathway_ids": ["PWY-5443"], "pathways": ["PWY-5443:t:aminopropanol phosphate biosynthesis I"], "type": "Family"}, "IPR005861": {"description": "Histidinol-phosphate aminotransferase family", "go_ids": ["GO:0000105", "GO:0004400"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0004400:L-histidinol-phosphate:2-oxoglutarate transaminase activity:F"], "name": "HisP_aminotrans", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005862": {"description": "Formate-dependent phosphoribosylglycinamide formyltransferase", "go_ids": ["GO:0004644", "GO:0000287", "GO:0005524", "GO:0009152", "GO:0016742"], "go_terms": ["GO:0004644:phosphoribosylglycinamide formyltransferase activity:F", "GO:0000287:magnesium ion binding:F", "GO:0005524:ATP binding:F", "GO:0009152:purine ribonucleotide biosynthetic process:P", "GO:0016742:hydroxymethyl-, formyl- and related transferase activity:F"], "name": "PurT", 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"pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005867": {"description": "Photosystem II protein D1", "go_ids": ["GO:0009055"], "go_terms": ["GO:0009055:electron transfer activity:F"], "name": "PSII_D1", "pathway_ids": ["PWY-101"], "pathways": ["PWY-101:t:photosynthesis light reactions"], "type": "Family"}, "IPR005868": {"description": "Photosystem II D2", "go_ids": ["GO:0016020", "GO:0019684", "GO:0009523", "GO:0015979"], "go_terms": ["GO:0016020:membrane:C", "GO:0019684:photosynthesis, light reaction:P", "GO:0009523:photosystem II:C", "GO:0015979:photosynthesis:P"], "name": "PSII_PsbD/D2", "pathway_ids": ["PWY-101"], "pathways": ["PWY-101:t:photosynthesis light reactions"], "type": "Family"}, "IPR005869": {"description": "Photosystem II CP43 reaction centre protein", "go_ids": ["GO:0009772", "GO:0016168", "GO:0015979", "GO:0016020", "GO:0009523"], "go_terms": ["GO:0009772:photosynthetic electron transport in photosystem II:P", "GO:0016168:chlorophyll binding:F", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C", "GO:0009523:photosystem II:C"], "name": "PSII_PsbC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005870": {"description": "Cytochrome b6/f complex, subunit IV", "go_ids": ["GO:0009767", "GO:0042651"], "go_terms": ["GO:0009767:photosynthetic electron transport chain:P", "GO:0042651:thylakoid membrane:C"], "name": "Cyt_b6/f_cplx_suIV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005871": {"description": "Photosynthetic reaction centre, L subunit", "go_ids": ["GO:0019684", "GO:0030077"], "go_terms": ["GO:0019684:photosynthesis, light reaction:P", "GO:0030077:plasma membrane light-harvesting complex:C"], "name": "Photo_RC_L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005872": {"description": "Archaeal/bacterial translation initiation factor SUI1", "go_ids": ["GO:0003743"], "go_terms": ["GO:0003743:translation initiation factor activity:F"], "name": "SUI1_arc_bac", "pathway_ids": [], 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constituent of ribosome:F", "GO:0005739:mitochondrion:C", "GO:0006412:translation:P", "GO:0015934:large ribosomal subunit:C"], "name": "Ribosomal_uL1_mit", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-BTA-9937383", "R-MMU-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR005880": {"description": "Large ribosomal subunit protein uL2, bacteria/organella", "go_ids": ["GO:0003723", "GO:0003735", "GO:0006412", "GO:0015934", "GO:0016740"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003735:structural constituent of ribosome:F", "GO:0006412:translation:P", "GO:0015934:large ribosomal subunit:C", "GO:0016740:transferase activity:F"], "name": "Ribosomal_uL2_bact_org", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005881": {"description": "Serine O-acetyltransferase", "go_ids": ["GO:0005737", "GO:0009001", "GO:0019344"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0009001:L-serine O-acetyltransferase activity:F", "GO:0019344:L-cysteine biosynthetic process:P"], "name": "Ser_O-AcTrfase", "pathway_ids": ["PWY-7274", "PWY-7870", "PWY-6936", "PWY-8071", "R-MTU-936721"], "pathways": ["PWY-7274:t:D-cycloserine biosynthesis", "PWY-7870:t:L-cysteine biosynthesis VII (from S-sulfo-L-cysteine)", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-8071:t:N-3-oxalyl-L-2,3-diaminopropanoate biosynthesis", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Family"}, "IPR005882": {"description": "Bifunctional protein GlmU", "go_ids": ["GO:0000287", "GO:0000902", "GO:0003977", "GO:0005737", "GO:0019134", "GO:0006048", "GO:0009252"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0000902:cell morphogenesis:P", "GO:0003977:UDP-N-acetylglucosamine diphosphorylase activity:F", "GO:0005737:cytoplasm:C", "GO:0019134:glucosamine-1-phosphate N-acetyltransferase activity:F", "GO:0006048:UDP-N-acetylglucosamine biosynthetic process:P", "GO:0009252:peptidoglycan biosynthetic process:P"], "name": "Bifunctional_GlmU", "pathway_ids": ["PWY-5514"], "pathways": ["PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II"], "type": "Family"}, "IPR005883": {"description": "Type IV pilus inner membrane component PilM", "go_ids": [], "go_terms": [], "name": "PilM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005884": {"description": "Fumarate reductase, flavoprotein subunit", "go_ids": ["GO:0009061", "GO:0016491"], "go_terms": ["GO:0009061:anaerobic respiration:P", "GO:0016491:oxidoreductase activity:F"], "name": "Fum_red_fp", "pathway_ids": ["PWY-4302", "PWY-3781", "PWY-8086", "PWY-7254", "PWY-6728", "PWY-5913", "PWY-7384", "PWY-561", "PWY-7279", "PWY-5690", "PWY-5392", "PWY-6969"], "pathways": ["PWY-4302:t:aerobic respiration III (alternative oxidase pathway)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-6728:t:methylaspartate cycle", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)"], "type": "Family"}, "IPR005885": {"description": "tRNA guanine(10)-N2-dimethyltransferase", "go_ids": ["GO:0160102", "GO:0030488"], "go_terms": ["GO:0160102:tRNA (guanine(10)-N2)-methyltransferase activity:F", "GO:0030488:tRNA methylation:P"], "name": "TrmG10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005886": {"description": "UDP-glucose 4-epimerase", "go_ids": ["GO:0003978", "GO:0006012"], "go_terms": ["GO:0003978:UDP-glucose 4-epimerase activity:F", "GO:0006012:galactose metabolic process:P"], "name": "UDP_G4E", "pathway_ids": ["PWY-6527", "PWY-7328", "PWY-3821", "PWY-6397", "PWY-7344", "PWY-6317", "R-MMU-70370", "R-SCE-70370", "R-HSA-70370", "R-HSA-5609977", "R-RNO-70370", "R-DME-70370", "R-SPO-70370", "R-DDI-70370", "R-CEL-70370"], "pathways": ["PWY-6527:t:stachyose degradation", "PWY-7328:t:superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis", "PWY-3821:t:D-galactose detoxification", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-7344:t:UDP-alpha-D-galactose biosynthesis", "PWY-6317:t:D-galactose degradation I (Leloir pathway)", "R-MMU-70370:r:Galactose catabolism", "R-SCE-70370:r:Galactose catabolism", "R-HSA-70370:r:Galactose catabolism", "R-HSA-5609977:r:Defective GALE causes EDG", "R-RNO-70370:r:Galactose catabolism", "R-DME-70370:r:Galactose catabolism", "R-SPO-70370:r:Galactose catabolism", "R-DDI-70370:r:Galactose catabolism", "R-CEL-70370:r:Galactose catabolism"], "type": "Family"}, "IPR005887": {"description": "Glycosyl hydrolase family 92, alpha-1,2-mannosidase, putative", "go_ids": [], "go_terms": [], "name": "GH92_a_mannosidase_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005888": {"description": "dTDP-glucose 4,6-dehydratase", "go_ids": ["GO:0008460", "GO:0009225"], "go_terms": ["GO:0008460:dTDP-glucose 4,6-dehydratase activity:F", "GO:0009225:nucleotide-sugar metabolic process:P"], "name": "dTDP_Gluc_deHydtase", "pathway_ids": ["PWY-7316", "PWY-7657", "PWY-7814", "PWY-6942", "PWY-7688", "PWY-6974", "PWY-7440", "PWY-6976", "PWY-7413", "PWY-7318", "PWY-7301", "PWY-7414", "PWY-6808", "PWY-8380", "PWY-6973", "PWY-7312", "PWY-6953", "PWY-7315", "PWY-7104"], "pathways": ["PWY-7316:t:dTDP-N-acetylviosamine biosynthesis", "PWY-7657:t:dTDP-beta-L-digitoxose biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-6942:t:dTDP-D-desosamine biosynthesis", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-6974:t:dTDP-beta-L-olivose biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7413:t:dTDP-6-deoxy-alpha-D-allose biosynthesis", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7414:t:dTDP-alpha-D-mycaminose biosynthesis", "PWY-6808:t:dTDP-alpha-D-forosamine biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWY-7312:t:dTDP-beta-D-fucofuranose biosynthesis", "PWY-6953:t:dTDP-3-acetamido-alpha-D-fucose biosynthesis", "PWY-7315:t:dTDP-N-acetylthomosamine biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis"], "type": "Family"}, "IPR005889": {"description": "Nitrate transport permease", "go_ids": ["GO:0015112", "GO:0015706", "GO:0016020"], "go_terms": ["GO:0015112:nitrate transmembrane transporter activity:F", "GO:0015706:nitrate transmembrane transport:P", "GO:0016020:membrane:C"], "name": "NtrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005890": {"description": "Nitrate transport ATP-binding subunit C/D-like", "go_ids": ["GO:0015112", "GO:0015706", "GO:0016020"], "go_terms": ["GO:0015112:nitrate transmembrane transporter activity:F", "GO:0015706:nitrate transmembrane transport:P", "GO:0016020:membrane:C"], "name": "NO3_transporter_ATP-bd-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005891": {"description": "DevC protein", "go_ids": [], "go_terms": [], "name": "DevC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005892": {"description": "Glycine betaine/proline betaine transport system ATP-binding protein ProV-like", "go_ids": ["GO:0005524", "GO:0016020", "GO:0031460"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016020:membrane:C", "GO:0031460:glycine betaine transport:P"], "name": "Gly-betaine_transp_ATP-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005893": {"description": "Spermidine/putrescine import ATP-binding protein PotA-like", "go_ids": ["GO:0015417", "GO:0015846", "GO:0043190"], "go_terms": ["GO:0015417:ABC-type polyamine transporter activity:F", "GO:0015846:polyamine transport:P", "GO:0043190:ATP-binding cassette (ABC) transporter complex:C"], "name": "PotA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005894": {"description": "Daunorubicin resistance ABC transporter ATP-binding subunit DrrA", "go_ids": ["GO:0005524", "GO:0043215", "GO:1900753"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0043215:daunorubicin transport:P", "GO:1900753:doxorubicin transport:P"], "name": "DrrA", "pathway_ids": ["PWY-6972"], "pathways": ["PWY-6972:t:oleandomycin activation/inactivation"], "type": "Family"}, "IPR005895": {"description": "ABC transporter, haem export, CcmA", "go_ids": ["GO:0017004", "GO:0022857"], "go_terms": ["GO:0017004:cytochrome complex assembly:P", "GO:0022857:transmembrane transporter activity:F"], "name": "ABC_transptr_haem_export_CcmA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005896": {"description": "Glucan exporter ATP-binding protein, NdvA", "go_ids": ["GO:0005886", "GO:0015775", "GO:0015441"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0015775:beta-glucan transport:P", "GO:0015441:ABC-type beta-glucan transporter activity:F"], "name": "NdvA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005897": {"description": "Peptidase C39, ABC-type bacteriocin transporter", "go_ids": ["GO:0008234", "GO:0016020", "GO:0043213", "GO:0043214"], "go_terms": ["GO:0008234:cysteine-type peptidase activity:F", "GO:0016020:membrane:C", "GO:0043213:bacteriocin transport:P", "GO:0043214:ABC-type bacteriocin transporter activity:F"], "name": "Pept_C39_ABC_bacteriocin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005898": {"description": "Cyclic peptide transporter SyrD/Yoji-like", "go_ids": ["GO:0005524", "GO:1904680", "GO:0015833", "GO:0016020"], "go_terms": ["GO:0005524:ATP binding:F", "GO:1904680:peptide transmembrane transporter activity:F", "GO:0015833:peptide transport:P", "GO:0016020:membrane:C"], "name": "Cyc_pep_transpt_SyrD/YojI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005899": {"description": "Sodium ion-translocating decarboxylase", "go_ids": ["GO:0015081", "GO:0016020", "GO:0036376"], "go_terms": ["GO:0015081:sodium ion transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0036376:sodium ion export across plasma membrane:P"], "name": "Na_pump_deCOase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005900": {"description": "6-phosphogluconolactonase, DevB-type", "go_ids": ["GO:0006098", "GO:0017057", "GO:0005975"], "go_terms": ["GO:0006098:pentose-phosphate shunt:P", "GO:0017057:6-phosphogluconolactonase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "6-phosphogluconolactonase_DevB", "pathway_ids": ["PWY-8004", "R-MMU-71336", "R-HSA-71336", "R-RNO-71336", "R-CEL-71336", "R-SPO-71336", "R-DME-71336", "R-SCE-71336", "R-DDI-71336"], "pathways": ["PWY-8004:t:Entner-Doudoroff pathway I", "R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-RNO-71336:r:Pentose phosphate pathway", "R-CEL-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-DME-71336:r:Pentose phosphate pathway", "R-SCE-71336:r:Pentose phosphate pathway", "R-DDI-71336:r:Pentose phosphate pathway"], "type": "Domain"}, "IPR005901": {"description": "GLPGLI family protein", "go_ids": [], "go_terms": [], "name": "GLPGLI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005902": {"description": "Putative DNA-binding protein, HU-related", "go_ids": [], "go_terms": [], "name": "HU_DNA-bd_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005903": {"description": "2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase", "go_ids": ["GO:0030494", "GO:0016491", "GO:0036354"], "go_terms": ["GO:0030494:bacteriochlorophyll biosynthetic process:P", "GO:0016491:oxidoreductase activity:F", "GO:0036354:bacteriochlorophyllide-a dehydrogenase activity:F"], "name": "BchC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005904": {"description": "Hypoxanthine phosphoribosyl transferase", "go_ids": ["GO:0004422", "GO:0006166"], "go_terms": ["GO:0004422:hypoxanthine phosphoribosyltransferase activity:F", "GO:0006166:purine ribonucleoside salvage:P"], "name": "Hxn_phspho_trans", "pathway_ids": ["PWY-6610", "PWY-6609", "PWY-6620", "PWY-6599", "R-MMU-9748787", "R-BTA-74217", "R-HSA-9748787", "R-DDI-74217", "R-DDI-9748787", "R-HSA-9734281", "R-RNO-74217", "R-BTA-9748787", "R-MMU-74217", "R-HSA-74217", "R-SSC-9748787", "R-RNO-9748787", "R-SSC-74217"], "pathways": ["PWY-6610:t:adenine salvage", "PWY-6609:t:adenine and adenosine salvage III", "PWY-6620:t:guanine and guanosine salvage I", "PWY-6599:t:guanine and guanosine salvage II", "R-MMU-9748787:r:Azathioprine ADME", "R-BTA-74217:r:Purine salvage", "R-HSA-9748787:r:Azathioprine ADME", "R-DDI-74217:r:Purine salvage", "R-DDI-9748787:r:Azathioprine ADME", "R-HSA-9734281:r:Defective HPRT1 disrupts guanine and hypoxanthine salvage", "R-RNO-74217:r:Purine salvage", "R-BTA-9748787:r:Azathioprine ADME", "R-MMU-74217:r:Purine salvage", "R-HSA-74217:r:Purine salvage", "R-SSC-9748787:r:Azathioprine ADME", "R-RNO-9748787:r:Azathioprine ADME", "R-SSC-74217:r:Purine salvage"], "type": "Family"}, "IPR005905": {"description": "D-alanine--D-alanine ligase", "go_ids": ["GO:0005737", "GO:0008716", "GO:0005524"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008716:D-alanine-D-alanine ligase activity:F", "GO:0005524:ATP binding:F"], "name": "D_ala_D_ala", "pathway_ids": ["PWY-7953", "PWY-6387", "PWY-6386"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "type": "Family"}, "IPR005906": {"description": "Lysine biosynthesis protein LysW", "go_ids": [], "go_terms": [], "name": "LysW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005907": {"description": "Glucose-1-phosphate thymidylyltransferase, short form", "go_ids": ["GO:0008879"], "go_terms": ["GO:0008879:glucose-1-phosphate thymidylyltransferase activity:F"], "name": "G1P_thy_trans_s", "pathway_ids": ["PWY-7316", "PWY-7657", "PWY-7814", "PWY-6942", "PWY-7688", "PWY-6974", "PWY-7440", "PWY-6976", "PWY-7413", "PWY-7318", "PWY-7301", "PWY-7414", "PWY-6808", "PWY-8380", "PWY-6973", "PWY-7312", "PWY-6953", "PWY-7315", "PWY-7104"], "pathways": ["PWY-7316:t:dTDP-N-acetylviosamine biosynthesis", "PWY-7657:t:dTDP-beta-L-digitoxose biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-6942:t:dTDP-D-desosamine biosynthesis", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-6974:t:dTDP-beta-L-olivose biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7413:t:dTDP-6-deoxy-alpha-D-allose biosynthesis", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7414:t:dTDP-alpha-D-mycaminose biosynthesis", "PWY-6808:t:dTDP-alpha-D-forosamine biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWY-7312:t:dTDP-beta-D-fucofuranose biosynthesis", "PWY-6953:t:dTDP-3-acetamido-alpha-D-fucose biosynthesis", "PWY-7315:t:dTDP-N-acetylthomosamine biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis"], "type": "Family"}, "IPR005908": {"description": "Glucose-1-phosphate thymidylyltransferase, long form", "go_ids": [], "go_terms": [], "name": "G1P_thy_trans_l", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005909": {"description": "Archaeosine synthase subunit beta", "go_ids": [], "go_terms": [], "name": "RaSEA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005911": {"description": "Protein YhcC-like", "go_ids": ["GO:0051536"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F"], "name": "YhcC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005913": {"description": "dTDP-4-dehydrorhamnose reductase", "go_ids": [], "go_terms": [], "name": "RmlD", "pathway_ids": ["R-MMU-5689880", "R-DRE-5689880", "R-BTA-5689880", "R-DRE-156581", "R-HSA-5689880", "R-RNO-156581", "R-HSA-156581", "R-MMU-156581", "R-RNO-5689880", "R-XTR-156581"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DRE-156581:r:Methylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-156581:r:Methylation", "R-HSA-156581:r:Methylation", "R-MMU-156581:r:Methylation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-XTR-156581:r:Methylation"], "type": "Family"}, "IPR005914": {"description": "Acetoacetyl-CoA synthase", "go_ids": ["GO:0006629", "GO:0030729"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0030729:acetoacetate-CoA ligase activity:F"], "name": "Acac_CoA_synth", "pathway_ids": ["PWY-8058", "R-HSA-77111", "R-MMU-77111", "R-DRE-77111", "R-CEL-77111", "R-RNO-77111"], "pathways": ["PWY-8058:t:2-deoxy-D-ribose degradation II", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-DRE-77111:r:Synthesis of Ketone Bodies", "R-CEL-77111:r:Synthesis of Ketone Bodies", "R-RNO-77111:r:Synthesis of Ketone Bodies"], "type": "Family"}, "IPR005915": {"description": "Tandem five-TM protein", "go_ids": [], "go_terms": [], "name": "Tandem_5TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005917": {"description": "Phosphomevalonate kinase, bacteria", "go_ids": [], "go_terms": [], "name": "Pmev_kinase_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005918": {"description": "Conantokin, conserved site", "go_ids": ["GO:0035792"], "go_terms": ["GO:0035792:host cell postsynaptic membrane:C"], "name": "Conantokin_CS", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR005919": {"description": "Higher eukaryotic phosphomevalonate kinase", "go_ids": ["GO:0004631", "GO:0005737", "GO:0006695"], "go_terms": ["GO:0004631:phosphomevalonate kinase activity:F", "GO:0005737:cytoplasm:C", "GO:0006695:cholesterol biosynthetic process:P"], "name": "Pmev_kin_anim", "pathway_ids": ["PWY-7391", "PWY-922", "R-MMU-9969896", "R-DME-9969896", "R-HSA-2426168", "R-SSC-9969896", "R-HSA-9969896"], "pathways": ["PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-DME-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SSC-9969896:r:Lanosterol biosynthesis", "R-HSA-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR005920": {"description": "Imidazolonepropionase", "go_ids": ["GO:0005737", "GO:0016812", "GO:0006548"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0016812:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides:F", "GO:0006548:L-histidine catabolic process:P"], "name": "HutI", "pathway_ids": ["PWY-5030", "PWY-5028", "R-DRE-70921", "R-MMU-70921", "R-XTR-70921", "R-CEL-70921", "R-BTA-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5028:t:L-histidine degradation II", "R-DRE-70921:r:Histidine catabolism", "R-MMU-70921:r:Histidine catabolism", "R-XTR-70921:r:Histidine catabolism", "R-CEL-70921:r:Histidine catabolism", "R-BTA-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Family"}, "IPR005921": {"description": "Histidine ammonia-lyase", "go_ids": ["GO:0004397", "GO:0005737", "GO:0006548"], "go_terms": ["GO:0004397:histidine ammonia-lyase activity:F", "GO:0005737:cytoplasm:C", "GO:0006548:L-histidine catabolic process:P"], "name": "HutH", "pathway_ids": ["PWY-5030", "PWY-5028", "R-MMU-70921", "R-RNO-70921", "R-CEL-70921", "R-BTA-70921", "R-HSA-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5028:t:L-histidine degradation II", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-CEL-70921:r:Histidine catabolism", "R-BTA-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism"], "type": "Family"}, "IPR005922": {"description": "Phenylalanine ammonia-lyase", "go_ids": ["GO:0005737", "GO:0006559", "GO:0016841"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006559:L-phenylalanine catabolic process:P", "GO:0016841:ammonia-lyase activity:F"], "name": "Phe_NH3-lyase", "pathway_ids": ["PWY-6444", "PWY-5883", "PWY-8157", "PWY-1121", "PWY-6457", "PWY-5048"], "pathways": ["PWY-6444:t:benzoate biosynthesis II (CoA-independent, non-beta-oxidative)", "PWY-5883:t:ephedrine biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-1121:t:suberin monomers biosynthesis", "PWY-6457:t:cinnamoyl-CoA biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I"], "type": "Family"}, "IPR005923": {"description": "Formiminoglutamase", "go_ids": ["GO:0050415", "GO:0006548"], "go_terms": ["GO:0050415:formimidoylglutamase activity:F", "GO:0006548:L-histidine catabolic process:P"], "name": "HutG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005925": {"description": "Agmatinase-related", "go_ids": [], "go_terms": [], "name": "Agmatinase-rel", "pathway_ids": ["PWY-40", "R-HSA-351143", "R-RNO-351143", "R-MMU-351143"], "pathways": ["PWY-40:t:putrescine biosynthesis I", "R-HSA-351143:r:Agmatine biosynthesis", "R-RNO-351143:r:Agmatine biosynthesis", "R-MMU-351143:r:Agmatine biosynthesis"], "type": "Family"}, "IPR005926": {"description": "Tagatose-6-phosphate kinase", "go_ids": ["GO:0009024"], "go_terms": ["GO:0009024:tagatose-6-phosphate kinase activity:F"], "name": "LacC", "pathway_ids": ["PWY-7395", "PWY-7077"], "pathways": ["PWY-7395:t:D-galactosamine and 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"name": "Daunbcin-R_ABC-transpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005943": {"description": "Daunorubicin resistance protein C", "go_ids": [], "go_terms": [], "name": "Daunbcin-R_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005944": {"description": "Proline iminopeptidase", "go_ids": ["GO:0004177", "GO:0005737", "GO:0006508"], "go_terms": ["GO:0004177:aminopeptidase activity:F", "GO:0005737:cytoplasm:C", "GO:0006508:proteolysis:P"], "name": "Pro_iminopeptidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005945": {"description": "Proline-specific peptidase", "go_ids": ["GO:0008233", "GO:0006508"], "go_terms": ["GO:0008233:peptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pro_imino_pep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005946": {"description": "Ribose-phosphate pyrophosphokinase", "go_ids": ["GO:0000287", "GO:0009165"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0009165:nucleotide 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"pathways": ["PWY-6030:t:serotonin and melatonin biosynthesis", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-209931:r:Serotonin and melatonin biosynthesis"], "type": "Family"}, "IPR005964": {"description": "Bacterial glucose/galactose transporter", "go_ids": ["GO:0005354", "GO:0015757", "GO:0016020", "GO:1904659", "GO:0055056"], "go_terms": ["GO:0005354:galactose transmembrane transporter activity:F", "GO:0015757:galactose transmembrane transport:P", "GO:0016020:membrane:C", "GO:1904659:D-glucose transmembrane transport:P", "GO:0055056:D-glucose transmembrane transporter activity:F"], "name": "Glc/Gal_transptr_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005965": {"description": "1-aminocyclopropane-1-carboxylate deaminase", "go_ids": ["GO:0008660", "GO:0009310", "GO:0030170"], "go_terms": ["GO:0008660:1-aminocyclopropane-1-carboxylate deaminase 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"GO:0042626:ATPase-coupled transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0071934:thiamine transmembrane transport:P"], "name": "Thiamine_ABC_ThiQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005969": {"description": "Light-independent protochlorophyllide reductase, B subunit", "go_ids": ["GO:0015995", "GO:0016730", "GO:0019685"], "go_terms": ["GO:0015995:chlorophyll biosynthetic process:P", "GO:0016730:oxidoreductase activity, acting on iron-sulfur proteins as donors:F", "GO:0019685:photosynthesis, dark reaction:P"], "name": "Protochl_reductB", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Family"}, "IPR005970": {"description": "Light-independent protochlorophyllide reductase, N subunit", "go_ids": ["GO:0015995", "GO:0016730", "GO:0019685"], "go_terms": ["GO:0015995:chlorophyll biosynthetic process:P", "GO:0016730:oxidoreductase activity, acting on iron-sulfur proteins as donors:F", "GO:0019685:photosynthesis, dark reaction:P"], "name": "Protochl_reductN", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Family"}, "IPR005971": {"description": "Light-independent protochlorophyllide reductase, iron-sulphur ATP-binding protein", "go_ids": ["GO:0005524", "GO:0015995", "GO:0016730", "GO:0019685"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0015995:chlorophyll biosynthetic process:P", "GO:0016730:oxidoreductase activity, acting on iron-sulfur proteins as donors:F", "GO:0019685:photosynthesis, dark reaction:P"], "name": "Protochlorophyllide_ATP-bd", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Family"}, "IPR005972": {"description": "Nitrogenase molybdenum-iron protein alpha chain", "go_ids": ["GO:0009399", "GO:0016163", "GO:0016612"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F", "GO:0016612:molybdenum-iron nitrogenase complex:C"], "name": "Nase_Mo-Fe_asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005973": {"description": "Nitrogenase MoFe cofactor biosynthesis protein NifE", "go_ids": ["GO:0065003", "GO:0009399"], "go_terms": ["GO:0065003:protein-containing complex assembly:P", "GO:0009399:nitrogen fixation:P"], "name": "NifE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005974": {"description": "Nitrogenase alpha chain", "go_ids": ["GO:0009399", "GO:0016163", "GO:0051536"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Nase_asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005975": {"description": "Nitrogenase molybdenum-iron cofactor biosynthesis protein", "go_ids": ["GO:0065003", "GO:0009399"], "go_terms": ["GO:0065003:protein-containing complex assembly:P", "GO:0009399:nitrogen fixation:P"], "name": "Nase_Mo-Fe_CF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005976": {"description": "Nitrogenase molybdenum-iron protein beta chain", "go_ids": ["GO:0009399", "GO:0016163", "GO:0016612"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F", "GO:0016612:molybdenum-iron nitrogenase complex:C"], "name": "Nase_Mo-Fe_CF_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005977": {"description": "Nitrogenase iron protein NifH", "go_ids": ["GO:0009399", "GO:0016163"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F"], "name": "Nitrogenase_Fe_NifH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005978": {"description": "Nodulation ABC transporter, NodI", "go_ids": ["GO:0005524", "GO:0016020", "GO:0022857"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016020:membrane:C", "GO:0022857:transmembrane transporter activity:F"], "name": "ABC_transptNodI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005979": {"description": "Protochlorophyllide reductase", "go_ids": ["GO:0016630"], "go_terms": ["GO:0016630:protochlorophyllide reductase activity:F"], "name": "Prochl_reduct", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005980": {"description": "Nitrogenase cofactor biosynthesis protein NifB", "go_ids": [], "go_terms": [], "name": "Nase_CF_NifB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005981": {"description": "ABC-2 type transporter, NodJ", "go_ids": ["GO:0015772", "GO:0016020", "GO:0022857"], "go_terms": ["GO:0015772:oligosaccharide transport:P", "GO:0016020:membrane:C", "GO:0022857:transmembrane transporter activity:F"], "name": "ABC_transptNodJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005982": {"description": "Thioredoxin reductase", "go_ids": ["GO:0004791", "GO:0005737", "GO:0019430"], "go_terms": ["GO:0004791:thioredoxin-disulfide reductase (NADPH) activity:F", "GO:0005737:cytoplasm:C", "GO:0019430:removal of superoxide radicals:P"], "name": "Thioredox_Rdtase", "pathway_ids": ["R-HSA-1222541"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis"], "type": "Family"}, "IPR005983": {"description": "Potassium channel, voltage-dependent, beta subunit, KCNAB", "go_ids": ["GO:0005249", "GO:0005737", "GO:0006813"], "go_terms": ["GO:0005249:voltage-gated potassium channel activity:F", "GO:0005737:cytoplasm:C", "GO:0006813:potassium ion transport:P"], "name": "K_chnl_volt-dep_bsu_KCNAB", "pathway_ids": ["PWY-5882", "PWY-5848", "PWY-7045", "PWY-5751", "PWY-7825", "PWY-7788", "PWY-5666", "PWY-8132", "PWY-8426", "PWY-5392", "PWY-6627", "PWY-6946", "PWY-7300", "PWY-6392", "PWY-6945", "PWY-6302", "PWY-8238", "PWY-7948", "PWY-7689", "PWY-8029", "PWY-7321", "PWY-7340", "PWY-7385", "PWY-7440", "PWY-7726", "PWY-5972", "PWY-7692", "PWY-1186", "PWY-8370", "PWY-7489", "PWY-7615", "PWY-7757", "PWY-7337", "PWY-6883", "PWY-7694", "PWY-7693", "PWY-6672", "PWY-7568", "PWY-3162", "PWY-5316", "PWY-5818", "PWY-7787", "PWY-6080", "PWY-7667", "PWY-6926", "PWY-6539", "PWY-5978", "PWY-6634", "PWY-5830", "PWY-8383", "PWY-6322", "PWY-8411", "PWY-7338", "PWY-6704", "PWY-6583", "PWY-8139", "PWY-5652", "PWY-8374", "PWY-7342", "PWY-7774", "PWY-6693", "PWY-7354", "PWY-7531", "PWY-7547", "PWY-6738", "PWY-8012", "PWY-6682", "PWY-7331", "PWY-7104", "PWY-7490", "PWY-6920", "PWY-7811", "PWY-7339", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7657", "PWY-8419", "PWY-5271", "PWY-7734", "PWY-7682", "PWY-7541", "PWY-6626", "PWY-6391", "PWY-6638", "PWY-8152", "PWY-3261", "PWY-8464", "PWY-6733", "PWY-321", "PWY-6637", "PWY-7660", "PWY-6944", "PWY-7288", "PWY-6659", "PWY-7301", "PWY-8367", "PWY-6786", "PWY-6973", "PWY-2541", "PWYG-321", "PWY-5883", "PWY-6053", "PWY-7042", "PWY-7742", "PWY-7621", "PWY-8410", "PWY-5867", "PWY-8214", "PWY-7554", "PWY-8409", "PWY-7814", "PWY-7557", "PWY-8297", "PWY-7403", "PWY-7241", "PWY-6948", "PWY-7610", "PWY-8155", "PWY-6974", "PWY-2601", "PWY-7396", "PWY-7695", "PWY-7304", "PWY-8058", "PWY-8366", "PWY-7043", "PWY-7520", "PWY-6863", "PWY-6976", "PWY-3722", "PWY-7352", "PWY-6989", "PWY-6061", "PWY-8408", "PWY-7649", "PWY-8397", "PWY-7613", "PWY-5782", "PWY-741", "PWY-7333", "PWY-5101", "PWY-7775", "PWY-1121", "PWY-7606", "PWY-7741", "PWY-7779", "R-HSA-6798695", "R-BTA-1296072", "R-GGA-1296072", "R-HSA-1296072", "R-MMU-6798695", "R-BTA-6798695", "R-RNO-1296072", "R-RNO-6798695", "R-MMU-1296072"], "pathways": ["PWY-5882:t:epoxypseudoisoeugenol-2-methylbutanoate biosynthesis", "PWY-5848:t:cinchona alkaloids biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-5751:t:phenylethanol biosynthesis", "PWY-7825:t:juglone degradation", "PWY-7788:t:erythritol degradation II", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-5392:t:reductive TCA cycle II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-6392:t:meso-butanediol biosynthesis II", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-7692:t:bikaverin biosynthesis", "PWY-1186:t:L-homomethionine biosynthesis", "PWY-8370:t:leporin B biosynthesis", "PWY-7489:t:oryzalexin A, B, and C biosynthesis", "PWY-7615:t:pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)", "PWY-7757:t:bisphenol A degradation", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7568:t:L-galactose degradation", "PWY-3162:t:L-tryptophan degradation V (side chain pathway)", "PWY-5316:t:nicotine biosynthesis", "PWY-5818:t:validamycin biosynthesis", "PWY-7787:t:L-threitol 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"PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6391:t:meso-butanediol biosynthesis I", "PWY-6638:t:sulfolactate degradation III", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-3261:t:UDP-beta-L-rhamnose biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-6637:t:sulfolactate degradation II", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-6053:t:dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)", "PWY-7042:t:the visual cycle (insects)", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "PWY-5867:t:t-anethole biosynthesis", "PWY-8214:t:3-sulfopropanediol degradation II", "PWY-7554:t:heme d1 biosynthesis", "PWY-8409:t:cyathin biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-8297:t:6-diazo-5-oxo-L-norleucine biosynthesis", "PWY-7403:t:tetramethylpyrazine degradation", "PWY-7241:t:myo-inositol degradation II", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-8155:t:testosterone degradation (anaerobic)", "PWY-6974:t:dTDP-beta-L-olivose biosynthesis", "PWY-2601:t:isethionate degradation", "PWY-7396:t:butanol and isobutanol 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II", "PWY-7775:t:propane degradation II", "PWY-1121:t:suberin monomers biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-GGA-1296072:r:Voltage gated Potassium channels", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-1296072:r:Voltage gated Potassium channels"], "type": "Family"}, "IPR005984": {"description": "Phospholamban", "go_ids": ["GO:0016020", "GO:0042030", "GO:1901894"], "go_terms": ["GO:0016020:membrane:C", "GO:0042030:ATPase inhibitor activity:F", "GO:1901894:regulation of ATPase-coupled calcium transmembrane transporter activity:P"], "name": "PLB", "pathway_ids": ["R-CFA-936837", "R-RNO-5578775", "R-CFA-5578775", "R-HSA-5578775", "R-MMU-5578775", "R-HSA-936837", "R-MMU-936837", "R-SSC-5578775", "R-RNO-936837", "R-SSC-936837"], "pathways": ["R-CFA-936837:r:Ion transport by P-type ATPases", "R-RNO-5578775:r:Ion homeostasis", "R-CFA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-SSC-5578775:r:Ion homeostasis", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SSC-936837:r:Ion transport by P-type ATPases"], "type": "Family"}, "IPR005985": {"description": "Pediocin PA-1 biosynthesis protein PedC", "go_ids": ["GO:0030152"], "go_terms": ["GO:0030152:bacteriocin biosynthetic process:P"], "name": "PedC_BrcD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR005986": {"description": "Aspartate-semialdehyde dehydrogenase, beta-type", "go_ids": ["GO:0004073", "GO:0009088", 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"IPR006005": {"description": "Glutamate synthase, NADH/NADPH, small subunit 1", "go_ids": ["GO:0016639", "GO:0097054"], "go_terms": ["GO:0016639:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor:F", "GO:0097054:L-glutamate biosynthetic process:P"], "name": "Glut_synth_ssu1", "pathway_ids": ["PWY-6963"], "pathways": ["PWY-6963:t:ammonia assimilation cycle I"], "type": "Family"}, "IPR006006": {"description": "Glutamate synthase NADPH small chain-like", "go_ids": ["GO:0051539"], "go_terms": ["GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "GltD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006007": {"description": "Inorganic carbon transporter", "go_ids": [], "go_terms": [], "name": "Inorganic_carbon_transpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006008": {"description": "Inner membrane-spanning protein YciB", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "YciB", 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reuptake and degradation", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-449836:r:Other interleukin signaling", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-449836:r:Other interleukin signaling", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-449836:r:Other interleukin signaling", "R-SCE-199992:r:trans-Golgi Network Vesicle Budding", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-5682910:r:LGI-ADAM interactions", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-888590:r:GABA synthesis, release, reuptake and 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"R-MMU-5673001", "R-BTA-9634597", "R-MMU-167044", "R-MMU-196025", "R-RNO-210993", "R-HSA-2424491", "R-MMU-9634597", "R-HSA-437239", "R-HSA-8983432", "R-CEL-212676", "R-BTA-8983432", "R-HSA-5637810", "R-HSA-5654699", "R-MMU-912526", "R-RNO-5654688", "R-RNO-8851805", "R-HSA-1445148", "R-MMU-9758890", "R-RNO-2730905", "R-MMU-2730905", "R-MMU-1250196", "R-BTA-8851805", "R-HSA-212676", "R-HSA-9609736", "R-MMU-354192", "R-HSA-9680350", "R-BTA-2424491", "R-RNO-2871796", "R-RNO-5654699", "R-HSA-9634597", "R-BTA-5654688", "R-RNO-5632684", "R-RNO-9842663", "R-HSA-8854214", "R-HSA-190873", "R-MMU-5654699", "R-HSA-9665348", "R-HSA-2428933", "R-MMU-418594", "R-RNO-9027284", "R-RNO-418594", "R-MMU-5693565", "R-RNO-167044", "R-RNO-5654719", "R-BTA-1250347", "R-HSA-196791", "R-MMU-190873", "R-RNO-354192", "R-BTA-912526", "R-MMU-5654704", "R-MMU-1250347", "R-MMU-8964038", "R-MMU-512988", "R-HSA-1250196", "R-RNO-8856828", "R-HSA-2730905", "R-HSA-5654719", "R-MMU-9027284", "R-BTA-512988", 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"R-HSA-9665686", "R-HSA-210993", "R-RNO-8853659", "R-BTA-74751", "R-MMU-8853659", "R-HSA-5673001", "R-RNO-196791", "R-MMU-8875513", "R-BTA-354192", "R-HSA-9674555", "R-MMU-5654688", "R-HSA-5654704", "R-RNO-4420097", "R-MMU-5610780", "R-HSA-167044", "R-RNO-9674555", "R-HSA-9725554", "R-HSA-2122948", "R-MMU-8856825", "R-HSA-74751", "R-HSA-418889", "R-HSA-1250347", "R-HSA-6794361", "R-MMU-9842663", "R-RNO-8875513", "R-RNO-5610780", "R-BTA-201556", "R-RNO-190873", "R-HSA-1236382", "R-BTA-2871796", "R-BTA-180336", "R-HSA-8851805", "R-MMU-5654719", "R-BTA-5654704", "R-HSA-354192", "R-RNO-8856825", "R-HSA-9662361", "R-HSA-5632684", "R-BTA-74749", "R-BTA-2730905", "R-HSA-418594", "R-RNO-74751", "R-RNO-2424491", "R-MMU-8866376", "R-MMU-2871809", "R-MMU-2424491", "R-RNO-1250196", "R-HSA-8866376"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-9674555:r:Signaling by CSF3 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"R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-8851805:r:MET activates RAS signaling", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-9758890:r:Transport of RCbl within the body", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-BTA-8851805:r:MET activates RAS signaling", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-354192:r:Integrin signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-BTA-2424491:r:DAP12 signaling", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9634597:r:GPER1 signaling", "R-BTA-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-9842663:r:Signaling by LTK", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-190873:r:Gap junction degradation", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-RNO-418594:r:G alpha (i) signalling events", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-167044:r:Signalling to RAS", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-190873:r:Gap junction degradation", "R-RNO-354192:r:Integrin signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-8964038:r:LDL clearance", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-HSA-196025:r:Formation of annular gap junctions", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-BTA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-437239:r:Recycling pathway of L1", "R-BTA-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-8964026:r:Chylomicron clearance", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-8964026:r:Chylomicron clearance", "R-DME-418594:r:G alpha (i) signalling events", "R-HSA-9842663:r:Signaling by LTK", "R-HSA-74749:r:Signal attenuation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9758890:r:Transport of RCbl within the body", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-201556:r:Signaling by ALK", "R-BTA-167044:r:Signalling to RAS", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-BTA-210993:r:Tie2 Signaling", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-74749:r:Signal attenuation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8964038:r:LDL clearance", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-8866376:r:Reelin signalling pathway", "R-RNO-74749:r:Signal attenuation", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-8964038:r:LDL clearance", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-RNO-9758890:r:Transport of RCbl within the body", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-196025:r:Formation of annular gap junctions", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-8853659:r:RET signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-BTA-8875513:r:MET interacts with TNS proteins", "R-CEL-8854214:r:TBC/RABGAPs", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-201556:r:Signaling by ALK", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-8853659:r:RET signaling", "R-BTA-74751:r:Insulin receptor signalling cascade", "R-MMU-8853659:r:RET signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-BTA-354192:r:Integrin signaling", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-167044:r:Signalling to RAS", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-6794361:r:Neurexins and neuroligins", "R-MMU-9842663:r:Signaling by LTK", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-201556:r:Signaling by ALK", "R-RNO-190873:r:Gap junction degradation", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-BTA-180336:r:SHC1 events in EGFR signaling", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-354192:r:Integrin signaling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-74749:r:Signal attenuation", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-RNO-2424491:r:DAP12 signaling", "R-MMU-8866376:r:Reelin signalling pathway", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-8866376:r:Reelin signalling pathway"], "type": "Domain"}, "IPR006024": {"description": "Opioid neuropeptide precursor", "go_ids": ["GO:0007218"], "go_terms": ["GO:0007218:neuropeptide signaling pathway:P"], "name": "Opioid_neupept", "pathway_ids": ["R-HSA-111885", "R-RNO-111885", "R-HSA-375276", "R-MMU-111885", "R-RNO-202040", "R-MMU-375276", "R-MMU-8957275", "R-MMU-418594", "R-RNO-418594", "R-BTA-8957275", "R-RNO-381426", "R-MMU-202040", "R-BTA-418594", "R-HSA-418594", "R-RNO-8957275", "R-HSA-202040", "R-RNO-375276", "R-BTA-381426", "R-MMU-381426", "R-HSA-8957275", "R-HSA-381426", "R-BTA-375276"], "pathways": ["R-HSA-111885:r:Opioid Signalling", "R-RNO-111885:r:Opioid Signalling", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-111885:r:Opioid Signalling", "R-RNO-202040:r:G-protein activation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-202040:r:G-protein activation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-202040:r:G-protein activation", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-375276:r:Peptide ligand-binding receptors"], "type": "Family"}, "IPR006026": {"description": "Peptidase, metallopeptidase", "go_ids": ["GO:0006508", "GO:0008237", "GO:0008270"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008237:metallopeptidase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Peptidase_Metallo", "pathway_ids": ["PWY-8119", "R-CEL-1592389", "R-HSA-6798695", "R-HSA-2243919", "R-RNO-2022090", "R-MMU-210991", "R-MMU-3928665", "R-RNO-1474228", "R-CEL-6798695", "R-RNO-9009391", "R-BTA-6798695", "R-HSA-2179392", "R-MMU-9009391", "R-CFA-1442490", "R-SSC-1474228", "R-MMU-2243919", "R-HSA-1650814", "R-MMU-2214320", "R-DME-2214320", "R-RNO-2179392", "R-GGA-9009391", "R-RNO-3928665", "R-DME-3928665", "R-DRE-1650814", "R-HSA-210991", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-MMU-1433557", "R-SSC-1592389", "R-DME-1650814", "R-MMU-1592389", "R-CEL-2214320", "R-BTA-1474228", "R-RNO-9839383", "R-DME-1592389", "R-HSA-6785807", "R-GGA-1442490", "R-HSA-8941332", "R-RNO-381426", "R-RNO-1433557", "R-BTA-1592389", "R-HSA-2022090", "R-CFA-1474228", "R-MMU-6798695", "R-CEL-1650814", "R-RNO-6798695", "R-MMU-9839383", "R-MMU-2179392", "R-GGA-1474228", "R-DRE-2243919", "R-BTA-1442490", "R-CEL-2179392", "R-CFA-2022090", "R-CEL-1474228", "R-SSC-1442490", "R-HSA-9918481", "R-GGA-1592389", "R-HSA-1442490", "R-BTA-1433557", "R-CFA-2179392", "R-HSA-2214320", "R-HSA-8963896", "R-CFA-1592389", "R-CEL-210991", "R-RNO-1592389", "R-DME-6798695", "R-DME-2179392", "R-CFA-9009391", "R-HSA-9839383", "R-HSA-1592389", "R-DME-2022090", "R-HSA-1433557", "R-RNO-1442490", "R-BTA-9009391", "R-DME-2243919", "R-CEL-3928665", "R-MMU-2022090", "R-DME-1474228", "R-MMU-8963896", "R-HSA-9009391", "R-MMU-1650814", "R-HSA-3928665", "R-GGA-3928665", "R-DME-1442490", "R-CEL-1442490", "R-HSA-9856530", "R-BTA-3928665", "R-MMU-1442490"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-210991:r:Basigin interactions", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-1442490:r:Collagen degradation", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2214320:r:Anchoring fibril formation", "R-DME-2214320:r:Anchoring fibril formation", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-210991:r:Basigin interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-SSC-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-CEL-2214320:r:Anchoring fibril formation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-1442490:r:Collagen degradation", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-DRE-2243919:r:Crosslinking of collagen fibrils", "R-BTA-1442490:r:Collagen degradation", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-SSC-1442490:r:Collagen degradation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-GGA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-CFA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8963896:r:HDL assembly", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-CEL-210991:r:Basigin interactions", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-1442490:r:Collagen degradation", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-2243919:r:Crosslinking of collagen fibrils", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-8963896:r:HDL assembly", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1442490:r:Collagen degradation", "R-CEL-1442490:r:Collagen degradation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1442490:r:Collagen degradation"], "type": "Domain"}, "IPR006027": {"description": "NusB/RsmB/TIM44", "go_ids": ["GO:0003723", "GO:0006355"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "NusB_RsmB_TIM44", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006029": {"description": "Neurotransmitter-gated ion-channel transmembrane domain", "go_ids": ["GO:0006811", "GO:0016020"], "go_terms": ["GO:0006811:monoatomic ion transport:P", "GO:0016020:membrane:C"], "name": "Neurotrans-gated_channel_TM", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-BTA-629597", "R-HSA-9667769", "R-DME-629594", "R-CEL-6798695", "R-HSA-977443", "R-GGA-977443", "R-BTA-112314", "R-DRE-629597", "R-BTA-629587", "R-CEL-112314", "R-HSA-629594", "R-RNO-112314", "R-RNO-629597", "R-MMU-112314", "R-MMU-629597", "R-DME-629587", "R-GGA-629587", "R-RNO-629594", "R-DRE-629594", "R-DME-6798695", "R-DME-977443", "R-RNO-629587", "R-GGA-629594", "R-DME-112314", "R-HSA-629587", "R-CEL-977443", "R-HSA-1236394", "R-CEL-629597", "R-GGA-629597", "R-BTA-977443", "R-CEL-629594", "R-DME-629597", "R-MMU-629587", "R-DRE-112314", "R-MMU-6798695", "R-MMU-977443", "R-BTA-629594", "R-HSA-112314", "R-CEL-629587", "R-MMU-629594", "R-HSA-629597", "R-RNO-977443"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-DME-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-CEL-6798695:r:Neutrophil degranulation", 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receptors", "R-RNO-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DRE-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-977443:r:GABA receptor activation", "R-RNO-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-GGA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-CEL-977443:r:GABA receptor activation", "R-HSA-1236394:r:Signaling by ERBB4", "R-CEL-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-GGA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-977443:r:GABA receptor activation", "R-CEL-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", 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"GO:0022857:transmembrane transporter activity:F"], "name": "Xan_ur_permease", "pathway_ids": ["R-RNO-196836", "R-XTR-196836", "R-HSA-196836", "R-MMU-196836"], "pathways": ["R-RNO-196836:r:Vitamin C (ascorbate) metabolism", "R-XTR-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-196836:r:Vitamin C (ascorbate) metabolism"], "type": "Family"}, "IPR006043": {"description": "Nucleobase cation symporter 2 family", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "NCS2", "pathway_ids": ["R-RNO-196836", "R-XTR-196836", "R-MMU-196836", "R-HSA-196836"], "pathways": ["R-RNO-196836:r:Vitamin C (ascorbate) metabolism", "R-XTR-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-196836:r:Vitamin C (ascorbate) metabolism"], "type": "Family"}, "IPR006045": {"description": "Cupin 1", "go_ids": [], "go_terms": [], "name": "Cupin_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006047": {"description": "Glycosyl hydrolase family 13, catalytic domain", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "GH13_cat_dom", "pathway_ids": ["R-HSA-71240", "R-MTU-868688", "R-HSA-189085", "R-MMU-3322077", "R-RNO-210991", "R-MMU-210991", "R-MMU-71240", "R-SCE-3322077", "R-HSA-9925561", "R-HSA-5619113", "R-MMU-352230", "R-HSA-352230", "R-RNO-352230", "R-HSA-5660862", "R-HSA-3322077", "R-HSA-3878781", "R-RNO-189085", "R-RNO-71240", "R-MMU-189085", "R-HSA-210991", "R-DME-189085", "R-HSA-5660883", "R-SCE-352230"], "pathways": ["R-HSA-71240:r:Tryptophan catabolism", "R-MTU-868688:r:Trehalose biosynthesis", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-MMU-3322077:r:Glycogen synthesis", "R-RNO-210991:r:Basigin interactions", "R-MMU-210991:r:Basigin interactions", "R-MMU-71240:r:Tryptophan catabolism", "R-SCE-3322077:r:Glycogen synthesis", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-5619113:r:Defective SLC3A1 causes cystinuria (CSNU)", "R-MMU-352230:r:Amino acid transport across the plasma membrane", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-HSA-5660862:r:Defective SLC7A7 causes lysinuric protein intolerance (LPI)", "R-HSA-3322077:r:Glycogen synthesis", "R-HSA-3878781:r:Glycogen storage disease type IV (GBE1)", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-RNO-71240:r:Tryptophan catabolism", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-HSA-210991:r:Basigin interactions", "R-DME-189085:r:Digestion of dietary carbohydrate", "R-HSA-5660883:r:Defective SLC7A9 causes cystinuria (CSNU)", "R-SCE-352230:r:Amino acid transport across the plasma membrane"], "type": "Domain"}, "IPR006048": {"description": "Alpha-amylase/branching enzyme, C-terminal all beta", "go_ids": ["GO:0003824", "GO:0005975", "GO:0043169"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0043169:cation binding:F"], "name": "A-amylase/branching_C", "pathway_ids": ["PWY-622", "PWY-7900", "PWY-5067", "R-HSA-189085", "R-MMU-3322077", "R-HSA-3322077", "R-HSA-3878781", "R-SCE-3322077", "R-RNO-189085", "R-HSA-9925561", "R-MMU-189085", "R-DME-189085"], "pathways": ["PWY-622:t:starch biosynthesis", "PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)", "PWY-5067:t:glycogen biosynthesis II (from UDP-D-Glucose)", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-MMU-3322077:r:Glycogen synthesis", "R-HSA-3322077:r:Glycogen synthesis", "R-HSA-3878781:r:Glycogen storage disease type IV (GBE1)", "R-SCE-3322077:r:Glycogen synthesis", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-DME-189085:r:Digestion of dietary carbohydrate"], "type": "Domain"}, "IPR006050": {"description": "DNA photolyase, N-terminal", "go_ids": [], "go_terms": [], "name": "DNA_photolyase_N", "pathway_ids": ["R-HSA-9931510", "R-DME-432553", "R-DME-432395", "R-HSA-9931530", "R-HSA-9932298", "R-HSA-9931521", "R-DME-538864"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-432395:r:Degradation of TIM", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-DME-538864:r:Degradation of CRY"], "type": "Domain"}, "IPR006052": {"description": "Tumour necrosis factor domain", "go_ids": ["GO:0005164", "GO:0006955", "GO:0016020"], "go_terms": ["GO:0005164:tumor necrosis factor receptor binding:F", "GO:0006955:immune response:P", "GO:0016020:membrane:C"], "name": "TNF_dom", "pathway_ids": ["R-MMU-9856649", "R-HSA-5218900", "R-HSA-9942503", "R-HSA-5626978", "R-RNO-5668541", "R-SSC-5357786", "R-HSA-5669034", "R-BTA-5668541", "R-RNO-5357905", "R-SSC-5669034", "R-CFA-198933", "R-HSA-75893", "R-SSC-5357905", "R-CFA-5676594", "R-RNO-5626978", "R-MMU-5668541", "R-MMU-3371378", "R-HSA-6783783", "R-HSA-9614657", "R-RNO-5676594", "R-MMU-75893", "R-RNO-198933", "R-CFA-5357786", "R-HSA-450520", "R-MMU-450520", "R-HSA-6785807", "R-DME-450520", "R-HSA-5357786", "R-HSA-75158", "R-SSC-5676594", "R-HSA-69416", "R-MMU-69416", "R-MMU-198933", "R-MMU-5357905", "R-HSA-198933", "R-MMU-5669034", "R-HSA-3371378", "R-MMU-75158", "R-SSC-75893", "R-MMU-5676594", "R-CFA-5668541", "R-HSA-5676594", "R-RNO-75157", "R-HSA-8862803", "R-BTA-5676594", "R-MMU-5357956", "R-MMU-75157", "R-HSA-5357905", "R-RNO-75893", "R-MMU-5218900", "R-RNO-3371378", "R-MMU-5626978", "R-CFA-5357956", "R-SSC-5668541", "R-MMU-5357786", "R-BTA-5669034", "R-RNO-9856649", "R-HSA-381340", "R-SSC-5357956", "R-CFA-75893", "R-RNO-69416", "R-SSC-5626978", "R-HSA-5668541", "R-HSA-5213460", "R-RNO-5218900", "R-CFA-5669034", "R-HSA-5357956", "R-HSA-75157", "R-RNO-5357956", "R-CFA-5626978", "R-HSA-9856649", "R-HSA-140534", "R-RNO-5357786", "R-CFA-5357905", "R-RNO-5669034"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-SSC-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-SSC-5669034:r:TNFs bind their physiological receptors", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-75893:r:TNF signaling", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-CFA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-3371378:r:Regulation by c-FLIP", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-RNO-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-75893:r:TNF signaling", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CFA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-75158:r:TRAIL signaling", "R-SSC-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-69416:r:Dimerization of procaspase-8", "R-MMU-69416:r:Dimerization of procaspase-8", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-HSA-3371378:r:Regulation by c-FLIP", "R-MMU-75158:r:TRAIL signaling", "R-SSC-75893:r:TNF signaling", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-RNO-75157:r:FasL/ CD95L signaling", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-BTA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-75157:r:FasL/ CD95L signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-75893:r:TNF signaling", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-RNO-3371378:r:Regulation by c-FLIP", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-5669034:r:TNFs bind their physiological receptors", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CFA-75893:r:TNF signaling", "R-RNO-69416:r:Dimerization of procaspase-8", "R-SSC-5626978:r:TNFR1-mediated ceramide production", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-5218900:r:CASP8 activity is inhibited", "R-CFA-5669034:r:TNFs bind their physiological receptors", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-75157:r:FasL/ CD95L signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CFA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5669034:r:TNFs bind their physiological receptors"], "type": "Domain"}, "IPR006054": {"description": "DNA polymerase III epsilon subunit, exonuclease domain", "go_ids": ["GO:0003677", "GO:0003887", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P"], "name": "DnaQ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006056": {"description": "RidA family", "go_ids": [], "go_terms": [], "name": "RidA", "pathway_ids": ["R-HSA-8849175", "R-MMU-8849175", "R-BTA-8849175", "R-DME-8849175", "R-CEL-8849175", "R-RNO-8849175"], "pathways": ["R-HSA-8849175:r:Threonine catabolism", "R-MMU-8849175:r:Threonine catabolism", "R-BTA-8849175:r:Threonine catabolism", "R-DME-8849175:r:Threonine catabolism", "R-CEL-8849175:r:Threonine catabolism", "R-RNO-8849175:r:Threonine catabolism"], "type": "Family"}, "IPR006059": {"description": "Bacterial-type extracellular solute-binding protein", "go_ids": [], "go_terms": [], "name": "SBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006062": {"description": "Histidine biosynthesis protein", "go_ids": ["GO:0000105"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P"], "name": "His_biosynth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006063": {"description": "HisA, bacterial", "go_ids": ["GO:0000105", "GO:0003949"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0003949:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity:F"], "name": "HisA_bact_arch", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006064": {"description": "Cytokinin glycosidase", "go_ids": [], "go_terms": [], "name": "Glycosidase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006067": {"description": "Nitrite/sulphite reductase 4Fe-4S domain", "go_ids": ["GO:0016491", "GO:0020037", "GO:0051536"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0020037:heme binding:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "NO2/SO3_Rdtase_4Fe4S_dom", "pathway_ids": ["PWY-6683", "R-MTU-936721"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Domain"}, "IPR006068": {"description": "Cation-transporting P-type ATPase, C-terminal", "go_ids": [], "go_terms": [], "name": "ATPase_P-typ_cation-transptr_C", "pathway_ids": ["R-GGA-936837", "R-DME-418359", "R-DDI-5578775", "R-BTA-936837", "R-SSC-936837", "R-CFA-936837", "R-MMU-418359", "R-HSA-9662360", "R-BTA-5578775", "R-CFA-5578775", "R-HSA-5578775", "R-MMU-936837", "R-CFA-418359", "R-SPO-5578775", "R-DDI-418359", "R-CEL-936837", "R-SCE-418359", "R-DDI-936837", "R-HSA-418359", "R-HSA-1912420", "R-CEL-418359", "R-GGA-418359", "R-DME-936837", "R-GGA-5578775", "R-DME-5578775", "R-RNO-5578775", "R-HSA-9662361", "R-RNO-418359", "R-SPO-418359", "R-MMU-5578775", "R-SPO-936837", "R-HSA-936837", "R-HSA-9679191", "R-SSC-5578775", "R-RNO-936837", "R-SCE-936837", "R-SCE-5578775", "R-CEL-5578775", "R-SSC-418359", "R-BTA-418359"], "pathways": ["R-GGA-936837:r:Ion transport by P-type ATPases", "R-DME-418359:r:Reduction of cytosolic Ca++ levels", "R-DDI-5578775:r:Ion homeostasis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-SSC-936837:r:Ion transport by P-type ATPases", "R-CFA-936837:r:Ion transport by P-type ATPases", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-5578775:r:Ion homeostasis", "R-CFA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CFA-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-5578775:r:Ion homeostasis", "R-DDI-418359:r:Reduction of cytosolic Ca++ levels", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-SCE-418359:r:Reduction of cytosolic Ca++ levels", "R-DDI-936837:r:Ion transport by P-type ATPases", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-CEL-418359:r:Reduction of cytosolic Ca++ levels", "R-GGA-418359:r:Reduction of cytosolic Ca++ levels", "R-DME-936837:r:Ion transport by P-type ATPases", "R-GGA-5578775:r:Ion homeostasis", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-5578775:r:Ion homeostasis", "R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SSC-5578775:r:Ion homeostasis", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases", "R-SCE-5578775:r:Ion homeostasis", "R-CEL-5578775:r:Ion homeostasis", "R-SSC-418359:r:Reduction of cytosolic Ca++ levels", "R-BTA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Domain"}, "IPR006070": {"description": "Threonylcarbamoyl-AMP synthase-like domain", "go_ids": ["GO:0003725"], "go_terms": ["GO:0003725:double-stranded RNA binding:F"], "name": "Sua5-like_dom", "pathway_ids": ["R-MMU-6787450", "R-HSA-6787450", "R-RNO-6787450", "R-BTA-6787450"], "pathways": ["R-MMU-6787450:r:tRNA modification in the mitochondrion", "R-HSA-6787450:r:tRNA modification in the mitochondrion", "R-RNO-6787450:r:tRNA modification in the mitochondrion", "R-BTA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR006072": {"description": "Odorant/pheromone binding protein, Lepidoptera", "go_ids": ["GO:0005549"], "go_terms": ["GO:0005549:odorant binding:F"], "name": "Odorant/phero-bd_Lep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006073": {"description": "GTP binding domain", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "GTP-bd", "pathway_ids": ["R-DRE-114608", "R-HSA-5419276", "R-XTR-6791226", "R-MMU-9937383", "R-DDI-6791226", "R-DME-6791226", "R-SCE-114608", "R-HSA-6787450", "R-SPO-114608", "R-RNO-114608", "R-BTA-5389840", "R-BTA-114608", "R-HSA-114608", "R-DRE-9937383", "R-HSA-5368286", "R-SCE-6791226", "R-RNO-5419276", "R-CEL-6791226", "R-HSA-5389840", "R-RNO-9937383", "R-RNO-5389840", "R-HSA-9629569", "R-DRE-5419276", "R-MMU-6791226", "R-CEL-5389840", "R-DDI-9629569", "R-DME-114608", "R-DME-9629569", "R-HSA-9937383", "R-CEL-114608", "R-GGA-114608", "R-DRE-5389840", "R-BTA-9937383", "R-MMU-5389840", "R-RNO-6791226", "R-MMU-9629569", "R-CEL-9937383", "R-HSA-6791226", "R-DRE-6791226", "R-MMU-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-BTA-9629569", "R-SPO-6791226", "R-MMU-114608"], "pathways": ["R-DRE-114608:r:Platelet degranulation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-114608:r:Platelet degranulation", "R-HSA-6787450:r:tRNA modification in the mitochondrion", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-5419276:r:Mitochondrial translation termination", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation 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pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-BTA-9629569:r:Protein hydroxylation", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR006075": {"description": "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic", "go_ids": ["GO:0016874"], "go_terms": ["GO:0016874:ligase activity:F"], "name": "Asn/Gln-tRNA_Trfase_suB/E_cat", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Domain"}, "IPR006076": {"description": "FAD dependent oxidoreductase", "go_ids": [], "go_terms": [], "name": "FAD-dep_OxRdtase", "pathway_ids": ["R-SSC-9033241", "R-RNO-1483166", "R-CEL-71064", "R-HSA-6799198", "R-MMU-6798163", "R-HSA-1483166", "R-DDI-880009", "R-BTA-9033241", "R-RNO-9033241", "R-SPO-1483166", "R-HSA-71064", "R-BTA-880009", "R-BTA-1483166", "R-SSC-389661", "R-MMU-389661", "R-SPO-611105", "R-SPO-163560", "R-MMU-163560", "R-BTA-71064", "R-DDI-9033241", "R-CEL-880009", "R-DDI-163560", "R-HSA-6798163", "R-CEL-163560", "R-HSA-204174", "R-MMU-71064", "R-RNO-6798163", "R-SPO-71064", "R-DDI-389661", "R-RNO-389661", "R-CEL-1483166", "R-MMU-9033241", "R-BTA-163560", "R-HSA-389661", "R-HSA-163560", "R-RNO-163560", "R-BTA-389661", "R-MMU-1483166", "R-SPO-9033241", "R-MMU-204174", "R-HSA-880009", "R-MMU-880009", "R-SCE-163560", "R-SPO-389661", "R-DDI-1483166", "R-CEL-389661", "R-DDI-8964208", "R-SCE-1483166", "R-HSA-9033241"], "pathways": ["R-SSC-9033241:r:Peroxisomal protein import", "R-RNO-1483166:r:Synthesis of PA", "R-CEL-71064:r:Lysine catabolism", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6798163:r:Choline catabolism", "R-HSA-1483166:r:Synthesis of PA", "R-DDI-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-BTA-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-1483166:r:Synthesis of PA", "R-HSA-71064:r:Lysine catabolism", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-BTA-1483166:r:Synthesis of PA", "R-SSC-389661:r:Glyoxylate metabolism and glycine degradation", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-SPO-611105:r:Respiratory electron transport", "R-SPO-163560:r:Triglyceride catabolism", "R-MMU-163560:r:Triglyceride catabolism", "R-BTA-71064:r:Lysine catabolism", "R-DDI-9033241:r:Peroxisomal protein import", "R-CEL-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DDI-163560:r:Triglyceride catabolism", "R-HSA-6798163:r:Choline catabolism", "R-CEL-163560:r:Triglyceride catabolism", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-71064:r:Lysine catabolism", "R-RNO-6798163:r:Choline catabolism", "R-SPO-71064:r:Lysine catabolism", "R-DDI-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-389661:r:Glyoxylate metabolism and glycine degradation", "R-CEL-1483166:r:Synthesis of PA", "R-MMU-9033241:r:Peroxisomal protein import", "R-BTA-163560:r:Triglyceride catabolism", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-163560:r:Triglyceride catabolism", "R-RNO-163560:r:Triglyceride catabolism", "R-BTA-389661:r:Glyoxylate metabolism and glycine degradation", "R-MMU-1483166:r:Synthesis of PA", "R-SPO-9033241:r:Peroxisomal protein import", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-SCE-163560:r:Triglyceride catabolism", "R-SPO-389661:r:Glyoxylate metabolism and glycine degradation", "R-DDI-1483166:r:Synthesis of PA", "R-CEL-389661:r:Glyoxylate metabolism and glycine degradation", "R-DDI-8964208:r:Phenylalanine metabolism", "R-SCE-1483166:r:Synthesis of PA", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR006077": {"description": "Vinculin/alpha-catenin", "go_ids": ["GO:0051015", "GO:0007155"], "go_terms": ["GO:0051015:actin filament binding:F", "GO:0007155:cell adhesion:P"], "name": "Vinculin/catenin", "pathway_ids": ["R-HSA-6798695", "R-SSC-6798695", "R-HSA-5674135", "R-MMU-5674135", "R-MMU-9856530", "R-HSA-6802952", "R-HSA-5626467", "R-CEL-6798695", "R-SSC-114608", "R-HSA-9766229", "R-DME-525793", "R-MMU-445355", "R-DME-445355", "R-RNO-114608", "R-RNO-9860927", "R-SSC-9764561", "R-HSA-418990", "R-HSA-114608", "R-HSA-9764561", "R-SSC-9856530", "R-HSA-5218920", "R-DRE-5626467", "R-RNO-445355", "R-MMU-9764561", "R-HSA-6802946", "R-HSA-9649948", "R-SSC-5674135", "R-RNO-5674135", "R-SSC-9860927", "R-HSA-525793", "R-HSA-6802955", "R-CEL-525793", "R-MMU-9766229", "R-RNO-9764561", "R-XTR-525793", "R-GGA-445355", "R-HSA-445355", "R-HSA-6802948", "R-MMU-5626467", "R-DME-6798695", "R-MMU-5218920", "R-DME-114608", "R-CEL-9764561", "R-DRE-9764561", "R-DRE-5218920", "R-CEL-114608", "R-GGA-114608", "R-CEL-5674135", "R-HSA-9764302", "R-GGA-6798695", "R-CEL-5218920", "R-MMU-418990", "R-GGA-9764561", "R-GGA-5674135", "R-DME-5218920", "R-RNO-9856530", "R-MMU-9860927", "R-MMU-114608", "R-SSC-445355", "R-CEL-445355", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-9833576", "R-MMU-525793", "R-HSA-9860927", "R-HSA-9856530", "R-DME-9764561", "R-HSA-9725370", "R-DRE-525793", "R-RNO-6798695", "R-HSA-9656223"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-CEL-6798695:r:Neutrophil degranulation", "R-SSC-114608:r:Platelet degranulation", "R-HSA-9766229:r:Degradation of CDH1", "R-DME-525793:r:Myogenesis", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-RNO-114608:r:Platelet degranulation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SSC-9764561:r:Regulation of CDH1 Function", "R-HSA-418990:r:Adherens junctions interactions", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9764561:r:Regulation of CDH1 Function", "R-SSC-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-445355:r:Smooth Muscle Contraction", "R-MMU-9764561:r:Regulation of CDH1 Function", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-525793:r:Myogenesis", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-CEL-525793:r:Myogenesis", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-9764561:r:Regulation of CDH1 Function", "R-XTR-525793:r:Myogenesis", "R-GGA-445355:r:Smooth Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-114608:r:Platelet degranulation", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-DRE-9764561:r:Regulation of CDH1 Function", "R-DRE-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-114608:r:Platelet degranulation", "R-GGA-114608:r:Platelet degranulation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-GGA-6798695:r:Neutrophil degranulation", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-418990:r:Adherens junctions interactions", "R-GGA-9764561:r:Regulation of CDH1 Function", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-114608:r:Platelet degranulation", "R-SSC-445355:r:Smooth Muscle Contraction", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9833576:r:CDH11 homotypic and heterotypic interactions", "R-MMU-525793:r:Myogenesis", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-9764561:r:Regulation of CDH1 Function", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DRE-525793:r:Myogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Family"}, "IPR006079": {"description": "Lantibiotic, Type A, Bacillales-type", "go_ids": ["GO:0005576", "GO:0042742"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042742:defense response to bacterium:P"], "name": "Lantibiotic_typ-A_Bacillales", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006080": {"description": "Beta/alpha-defensin, C-terminal", "go_ids": ["GO:0005576", "GO:0006952"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006952:defense response:P"], "name": "Beta/alpha-defensin_C", "pathway_ids": ["R-RNO-1462054", "R-HSA-6798695", "R-BTA-1461973", "R-HSA-1462054", "R-SSC-1461957", "R-RNO-1461973", "R-BTA-1461957", "R-HSA-9841251", "R-MMU-6798695", "R-MMU-1461973", "R-MMU-1462054", "R-HSA-1461957", "R-RNO-6798695", "R-HSA-1461973"], "pathways": ["R-RNO-1462054:r:Alpha-defensins", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-1461973:r:Defensins", "R-HSA-1462054:r:Alpha-defensins", "R-SSC-1461957:r:Beta defensins", "R-RNO-1461973:r:Defensins", "R-BTA-1461957:r:Beta defensins", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-1461973:r:Defensins", "R-MMU-1462054:r:Alpha-defensins", "R-HSA-1461957:r:Beta defensins", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-1461973:r:Defensins"], "type": "Domain"}, "IPR006081": {"description": "Alpha-defensin, C-terminal", "go_ids": ["GO:0005576", "GO:0006952"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006952:defense response:P"], "name": "Alpha-defensin_C", "pathway_ids": ["R-RNO-1462054", "R-HSA-6798695", "R-HSA-1462054", "R-RNO-1461973", "R-HSA-9841251", "R-MMU-6798695", "R-MMU-1461973", "R-MMU-1462054", "R-RNO-6798695", "R-HSA-1461973"], "pathways": ["R-RNO-1462054:r:Alpha-defensins", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1462054:r:Alpha-defensins", "R-RNO-1461973:r:Defensins", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-1461973:r:Defensins", "R-MMU-1462054:r:Alpha-defensins", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-1461973:r:Defensins"], "type": "Domain"}, "IPR006083": {"description": "Phosphoribulokinase/uridine kinase", "go_ids": ["GO:0005524", "GO:0016301"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016301:kinase activity:F"], "name": "PRK/URK", "pathway_ids": ["R-XTR-73614", "R-CEL-73614", "R-DRE-73614", "R-HSA-73614", "R-SPO-73614", "R-RNO-73614", "R-SCE-196807", "R-SCE-73614", "R-MMU-73614", "R-DDI-196807", "R-DME-73614", "R-DDI-73614"], "pathways": ["R-XTR-73614:r:Pyrimidine salvage", "R-CEL-73614:r:Pyrimidine salvage", "R-DRE-73614:r:Pyrimidine salvage", "R-HSA-73614:r:Pyrimidine salvage", "R-SPO-73614:r:Pyrimidine salvage", "R-RNO-73614:r:Pyrimidine salvage", "R-SCE-196807:r:Nicotinate metabolism", "R-SCE-73614:r:Pyrimidine salvage", "R-MMU-73614:r:Pyrimidine salvage", "R-DDI-196807:r:Nicotinate metabolism", "R-DME-73614:r:Pyrimidine salvage", "R-DDI-73614:r:Pyrimidine salvage"], "type": "Domain"}, "IPR006084": {"description": "XPG/Rad2 endonuclease", "go_ids": [], "go_terms": [], "name": "XPG/Rad2", "pathway_ids": ["R-SPO-5696395", "R-MMU-5696395", "R-HSA-9709570", "R-HSA-5693607", "R-CEL-5685939", 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"R-DRE-69166:r:Removal of the Flap Intermediate", "R-DME-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DDI-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-XTR-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DDI-69166:r:Removal of the Flap Intermediate", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-69166:r:Removal of the Flap Intermediate", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Domain"}, "IPR006091": {"description": "Acyl-CoA dehydrogenase/oxidase, middle domain", "go_ids": ["GO:0016627"], "go_terms": ["GO:0016627:oxidoreductase activity, acting on the CH-CH group of donors:F"], "name": "AcylCoA_DH/ox_M", "pathway_ids": ["R-HSA-1989781", "R-CEL-71064", "R-HSA-6799198", "R-RNO-6799198", "R-RNO-2046106", "R-DME-77288", "R-DDI-71064", "R-HSA-77346", "R-MMU-77352", "R-RNO-77305", "R-BTA-9033241", "R-DME-77348", "R-RNO-9033241", "R-MMU-77346", "R-MMU-389887", "R-RNO-77285", "R-RNO-389887", "R-RNO-77289", "R-BTA-9837999", "R-HSA-71064", "R-HSA-77352", "R-HSA-77289", "R-DME-77346", "R-BTA-70895", "R-MMU-6799198", "R-MMU-77350", "R-DME-389887", "R-HSA-389887", "R-HSA-70895", "R-HSA-77348", "R-BTA-2046106", "R-MMU-77348", "R-BTA-77305", "R-HSA-77310", "R-BTA-77346", "R-SSC-77285", "R-HSA-390247", "R-MMU-77289", "R-MMU-390247", "R-HSA-2046106", "R-MMU-77288", "R-RNO-77352", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-DDI-70895", "R-RNO-77310", "R-HSA-77350", "R-DME-2046106", "R-HSA-77285", "R-BTA-77288", "R-SSC-77310", "R-RNO-77350", "R-RNO-77288", "R-MMU-70895", "R-MMU-77310", "R-RNO-77348", "R-HSA-9837999", "R-HSA-77305", "R-DME-390247", "R-BTA-71064", "R-DDI-9837999", "R-HSA-381038", "R-MMU-71064", "R-MMU-2046106", "R-DME-9033241", "R-MMU-9033241", "R-RNO-9837999", "R-MMU-77285", "R-BTA-77348", "R-RNO-70895", "R-SCE-389887", "R-MMU-77305", "R-DME-193368", "R-BTA-390247", "R-HSA-9033500", "R-HSA-9033241", "R-HSA-9914355", "R-RNO-390247"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-CEL-71064:r:Lysine catabolism", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-71064:r:Lysine catabolism", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-BTA-9033241:r:Peroxisomal protein import", "R-DME-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-71064:r:Lysine catabolism", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-6799198:r:Complex I biogenesis", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-BTA-71064:r:Lysine catabolism", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-71064:r:Lysine catabolism", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-9914355:r:Isovaleric acidemia", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR006094": {"description": "FAD linked oxidase, N-terminal", "go_ids": ["GO:0050660"], "go_terms": ["GO:0050660:flavin adenine dinucleotide binding:F"], "name": "Oxid_FAD_bind_N", "pathway_ids": ["PWY-7953", "PWY-6387", "PWY-6386", "R-MMU-9837999", "R-DRE-880009", "R-HSA-9969901", "R-DRE-1268020", "R-RNO-6807062", "R-DME-9033241", "R-CEL-75896", "R-RNO-75896", "R-MMU-9969901", "R-MMU-9033241", "R-HSA-6807062", "R-SCE-880009", "R-RNO-9969901", "R-MMU-75896", "R-DRE-9837999", "R-CEL-6807062", "R-SPO-880009", "R-HSA-6807047", "R-RNO-9033241", "R-MMU-6807047", "R-HSA-880009", "R-MMU-880009", "R-HSA-1268020", "R-HSA-75896", "R-CEL-6807047", "R-SCE-9837999", "R-BTA-880009", "R-MMU-1268020", "R-HSA-9837999", "R-HSA-9033500", "R-RNO-6807047", "R-MMU-6807062", "R-HSA-9033241", "R-RNO-880009", "R-DME-75896", "R-CEL-9969901"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DRE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-DRE-1268020:r:Mitochondrial protein import", "R-RNO-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-DME-9033241:r:Peroxisomal protein import", "R-CEL-75896:r:Plasmalogen biosynthesis", "R-RNO-75896:r:Plasmalogen biosynthesis", "R-MMU-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-SCE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-MMU-75896:r:Plasmalogen biosynthesis", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-CEL-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-SPO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-75896:r:Plasmalogen biosynthesis", "R-CEL-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DME-75896:r:Plasmalogen biosynthesis", "R-CEL-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "type": "Domain"}, "IPR006096": {"description": "Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal", "go_ids": ["GO:0006520", "GO:0016491"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0016491:oxidoreductase activity:F"], "name": "Glu/Leu/Phe/Val/Trp_DH_C", "pathway_ids": ["R-DDI-9837999", "R-MMU-9837999", "R-HSA-2151201", "R-DDI-8964539", "R-MMU-8964539", "R-DME-9837999", "R-RNO-9837999", "R-MMU-2151201", "R-HSA-8964539", "R-DME-2151201", "R-DME-8964539", "R-RNO-8964539", "R-RNO-2151201", "R-SSC-9837999", "R-HSA-9837999", "R-SSC-8964539", "R-SSC-2151201"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DDI-8964539:r:Glutamate and glutamine metabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-8964539:r:Glutamate and glutamine metabolism", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-RNO-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-8964539:r:Glutamate and glutamine metabolism", "R-SSC-2151201:r:Transcriptional activation of mitochondrial biogenesis"], "type": "Domain"}, "IPR006097": {"description": "Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain", "go_ids": ["GO:0006520", "GO:0016491"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0016491:oxidoreductase activity:F"], "name": "Glu/Leu/Phe/Val/Trp_DH_dimer", "pathway_ids": ["R-DDI-9837999", "R-MMU-9837999", "R-HSA-2151201", "R-DDI-8964539", "R-MMU-8964539", "R-DME-9837999", "R-RNO-9837999", "R-MMU-2151201", "R-HSA-8964539", "R-DME-2151201", "R-DME-8964539", "R-RNO-8964539", "R-RNO-2151201", "R-SSC-9837999", "R-HSA-9837999", "R-SSC-8964539", "R-SSC-2151201"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DDI-8964539:r:Glutamate and glutamine metabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-8964539:r:Glutamate and glutamine metabolism", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-RNO-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-8964539:r:Glutamate and glutamine metabolism", "R-SSC-2151201:r:Transcriptional activation of mitochondrial biogenesis"], "type": "Domain"}, "IPR006098": {"description": "Methylmalonyl-CoA mutase, alpha chain, catalytic", "go_ids": ["GO:0004494", "GO:0031419"], "go_terms": ["GO:0004494:methylmalonyl-CoA mutase activity:F", "GO:0031419:cobalamin binding:F"], "name": "MMCoA_mutase_a_cat", "pathway_ids": ["PWY-5743", "PWY-8086", "PWY-5789", "PWY-7854", "PWY-7384", "PWY-6728", "R-HSA-3359475", "R-HSA-9759218", "R-MMU-71032", "R-HSA-3359478", "R-CEL-71032", "R-CEL-9759218", "R-HSA-71032", "R-MMU-9759218"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-6728:t:methylaspartate cycle", "R-HSA-3359475:r:Defective MMAA causes MMA, cblA type", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-3359478:r:Defective MUT causes MMAM", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism"], "type": "Domain"}, "IPR006099": {"description": "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic", "go_ids": ["GO:0016866", "GO:0031419"], "go_terms": ["GO:0016866:intramolecular transferase activity:F", "GO:0031419:cobalamin binding:F"], "name": "MeMalonylCoA_mutase_a/b_cat", "pathway_ids": ["PWY-5743", "PWY-8086", "PWY-5789", "PWY-7854", "PWY-7384", "PWY-6728", "R-HSA-3359475", "R-HSA-9759218", "R-MMU-71032", "R-HSA-3359478", "R-CEL-71032", "R-CEL-9759218", "R-HSA-71032", "R-MMU-9759218"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-6728:t:methylaspartate cycle", "R-HSA-3359475:r:Defective MMAA causes MMA, cblA type", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-3359478:r:Defective MUT causes MMAM", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism"], "type": "Domain"}, "IPR006102": {"description": "Glycoside hydrolase family 2, immunoglobulin-like beta-sandwich", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Ig-like_GH2", "pathway_ids": ["PWY-6807", "R-HSA-2024101", "R-HSA-6798695", "R-SSC-2160916", "R-SSC-6798695", "R-HSA-9953080", "R-HSA-2160916", "R-RNO-2024101", "R-CEL-8853383", "R-CEL-6798695", "R-MMU-2024101", "R-MMU-6798695", "R-SSC-2024101", "R-HSA-2206292", "R-MMU-2160916", "R-RNO-2160916", "R-RNO-6798695"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-2160916:r:Hyaluronan degradation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-9953080:r:MPS VII - Sly syndrome (CS/DS degradation)", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-2024101:r:CS/DS degradation", "R-CEL-8853383:r:Lysosomal oligosaccharide catabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-2024101:r:CS/DS degradation", "R-HSA-2206292:r:MPS VII - Sly syndrome (Hyaluronan metabolism)", "R-MMU-2160916:r:Hyaluronan degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR006103": {"description": "Glycoside hydrolase family 2, catalytic domain", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_2_cat", "pathway_ids": ["PWY-6807", "R-HSA-2024101", "R-HSA-6798695", "R-SSC-2160916", "R-RNO-8853383", "R-SSC-6798695", "R-HSA-9953080", "R-HSA-2160916", "R-MMU-8853383", "R-RNO-2024101", "R-HSA-8853383", "R-MMU-2024101", "R-MMU-6798695", "R-SSC-2024101", "R-HSA-2206292", "R-MMU-2160916", "R-RNO-2160916", "R-RNO-6798695"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-2160916:r:Hyaluronan degradation", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-9953080:r:MPS VII - Sly syndrome (CS/DS degradation)", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-2024101:r:CS/DS degradation", "R-HSA-2206292:r:MPS VII - Sly syndrome (Hyaluronan metabolism)", "R-MMU-2160916:r:Hyaluronan degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR006104": {"description": "Glycosyl hydrolases family 2, sugar binding domain", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_2_N", "pathway_ids": ["PWY-6807", "R-HSA-2024101", "R-HSA-6798695", "R-SSC-2160916", "R-SSC-6798695", "R-HSA-9953080", "R-HSA-2160916", "R-RNO-2024101", "R-MMU-2024101", "R-MMU-6798695", "R-SSC-2024101", "R-HSA-2206292", "R-MMU-2160916", "R-RNO-2160916", "R-RNO-6798695"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-2160916:r:Hyaluronan degradation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-9953080:r:MPS VII - Sly syndrome (CS/DS degradation)", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-2024101:r:CS/DS degradation", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-2024101:r:CS/DS degradation", "R-HSA-2206292:r:MPS VII - Sly syndrome (Hyaluronan metabolism)", "R-MMU-2160916:r:Hyaluronan degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR006106": {"description": "Cereal seed allergen/grain softness/trypsin and alpha-amylase inhibitor", "go_ids": ["GO:0004867"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F"], "name": "Allergen/soft/tryp_amyl_inhib", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006108": {"description": "3-hydroxyacyl-CoA dehydrogenase, C-terminal", "go_ids": ["GO:0006631", "GO:0016491", "GO:0016616"], "go_terms": ["GO:0006631:fatty acid metabolic process:P", "GO:0016491:oxidoreductase activity:F", "GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "3HC_DH_C", "pathway_ids": ["PWY-8182", "PWY-7007", "PWY-7401", "PWY-8354", "PWY-6435", "PWY-6443", "PWY-6583", "PWY-6946", "PWY-8181", "PWY-6945", "PWY-6458", "PWY-6446", "PWY-8152", "PWY-7726", "PWY-6944", "PWY-6863", "PWY-5789", "PWY-7654", "PWY-5136", "PWY-1361", "PWY-7778", "PWY-7656", "PWY-7216", "PWY-5138", "PWY-8347", "PWY-6883", "PWY-7094", "PWY-8179", "PWY-7606", "PWY-5177", "PWY-7779", "R-RNO-1482798", "R-RNO-77352", "R-RNO-5661270", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-CEL-77348", "R-DRE-390247", "R-CEL-77350", "R-RNO-77310", "R-HSA-77350", "R-HSA-77285", "R-HSA-77346", "R-MMU-77352", "R-SSC-77346", "R-RNO-77305", "R-HSA-5661270", "R-SSC-77310", "R-RNO-9033241", "R-MMU-77346", "R-RNO-77350", "R-RNO-77285", "R-MMU-5661270", "R-MMU-77310", "R-RNO-77348", "R-MMU-1482798", "R-HSA-77305", "R-HSA-9837999", "R-SSC-77305", "R-HSA-77352", "R-CEL-77346", "R-SSC-77352", "R-SSC-77348", "R-CEL-9837999", "R-SSC-77350", "R-CEL-77352", "R-MMU-77350", "R-SSC-1482798", "R-HSA-77348", "R-CEL-77310", "R-MMU-77348", "R-MMU-9033241", "R-MMU-77285", "R-HSA-1482798", "R-RNO-9837999", "R-MMU-77305", "R-BTA-5661270", "R-HSA-77310", "R-SSC-77285", "R-HSA-390247", "R-MMU-390247", "R-SSC-9837999", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8354:t:adipate degradation", "PWY-6435:t:4-hydroxybenzoate biosynthesis III (plants)", "PWY-6443:t:benzoate biosynthesis I (CoA-dependent, beta-oxidative)", "PWY-6583:t:pyruvate fermentation to butanol I", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-6458:t:benzoyl-CoA biosynthesis", "PWY-6446:t:benzoate biosynthesis III (CoA-dependent, non-beta-oxidative)", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-1361:t:benzoyl-CoA degradation I (aerobic)", "PWY-7778:t:2-methylpropene degradation", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-5138:t:fatty acid beta-oxidation IV (unsaturated, even number)", "PWY-8347:t:adipate biosynthesis", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7094:t:fatty acid salvage", "PWY-8179:t:platensimycin biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5177:t:glutaryl-CoA degradation", "PWY-7779:t:methyl tert-butyl ether degradation", "R-RNO-1482798:r:Acyl chain remodeling of CL", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-CEL-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-DRE-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SSC-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SSC-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SSC-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SSC-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-CEL-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-SSC-1482798:r:Acyl chain remodeling of CL", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-CEL-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-BTA-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR006109": {"description": "Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal", "go_ids": ["GO:0005975", "GO:0006072"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0006072:glycerol-3-phosphate metabolic process:P"], "name": "G3P_DH_NAD-dep_C", "pathway_ids": ["PWY-5981", "PWY-7902", "PWY-5667", "R-MMU-1483166", "R-DRE-1483166", "R-SPO-1483166", "R-RNO-1483166", "R-CEL-1483166", "R-XTR-1483166", "R-HSA-1483166", "R-SCE-1483166", "R-DME-1483166"], "pathways": ["PWY-5981:t:CDP-diacylglycerol biosynthesis III", "PWY-7902:t:glucosylglycerol biosynthesis", "PWY-5667:t:CDP-diacylglycerol biosynthesis I", "R-MMU-1483166:r:Synthesis of PA", "R-DRE-1483166:r:Synthesis of PA", "R-SPO-1483166:r:Synthesis of PA", "R-RNO-1483166:r:Synthesis of PA", "R-CEL-1483166:r:Synthesis of PA", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-1483166:r:Synthesis of PA", "R-SCE-1483166:r:Synthesis of PA", "R-DME-1483166:r:Synthesis of PA"], "type": "Domain"}, "IPR006110": {"description": "RNA polymerase, subunit omega/Rpo6/RPB6", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "Pol_omega/Rpo6/RPB6", "pathway_ids": ["R-RNO-6781823", "R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-CEL-72165", "R-DME-76061", "R-MMU-9770562", "R-RNO-73779", "R-HSA-73980", "R-HSA-427413", "R-CEL-72203", "R-DDI-73776", "R-DME-72163", "R-RNO-72163", "R-DDI-6782210", "R-SPO-6781823", "R-DME-75955", "R-DDI-72163", "R-RNO-9018519", "R-HSA-167158", "R-MMU-75955", "R-RNO-73776", "R-MMU-112382", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DME-72203", "R-DME-72086", "R-DDI-674695", "R-CEL-9770562", "R-HSA-76061", "R-MMU-76061", "R-CEL-75953", "R-SPO-6796648", "R-DME-75953", "R-HSA-749476", "R-CEL-73776", "R-DME-6782135", "R-SCE-76061", "R-DME-73762", "R-SPO-9018519", "R-SPO-76066", "R-MMU-72163", "R-HSA-6803529", "R-HSA-167242", "R-CEL-6782210", "R-HSA-8851708", "R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-RNO-76061", "R-CEL-112382", "R-HSA-9670095", "R-HSA-167160", "R-CEL-6782135", "R-DDI-77075", "R-SPO-73779", "R-MMU-73772", "R-MMU-72086", "R-DDI-113418", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-DME-5578749", "R-DME-73779", "R-DME-77075", "R-CEL-73772", "R-DME-9770562", "R-DME-73776", "R-MMU-6781823", "R-HSA-203927", "R-DDI-73772", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-HSA-73780", "R-MMU-73776", "R-DDI-76042", "R-CEL-72163", "R-HSA-167172", "R-SCE-73779", "R-RNO-113418", "R-HSA-76071", "R-DME-113418", "R-HSA-72203", "R-MMU-6796648", "R-RNO-76071", "R-HSA-9770562", "R-CEL-75955", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-SCE-6781823", "R-MMU-76071", "R-RNO-76066", "R-SCE-9018519", "R-HSA-73863", "R-RNO-77075", "R-HSA-167290", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-DME-76066", "R-CEL-9018519", "R-RNO-9770562", "R-DME-6782210", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-RNO-6807505", "R-MMU-72203", "R-RNO-674695", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-SPO-6807505", "R-RNO-73863", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-RNO-72165", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-SPO-73762", "R-RNO-6782210", "R-SPO-75953", "R-HSA-5601884", "R-SPO-113418", "R-MMU-5250924", "R-CEL-6807505", "R-DME-674695", "R-RNO-72203", "R-RNO-76042", "R-DME-9018519", "R-DDI-73779", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-CEL-113418", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-MMU-6807505", "R-RNO-5578749", "R-SCE-76042", "R-MMU-9018519", "R-CEL-6781823", "R-SPO-9770562", "R-DME-6807505", "R-DDI-6807505", "R-HSA-167200", "R-SCE-73762", "R-DME-72165", "R-RNO-112382", "R-SCE-674695", "R-MMU-6782210", "R-CEL-6796648", "R-RNO-75953", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-SCE-76066", "R-MMU-73762", "R-MMU-6782135", "R-HSA-76066", "R-HSA-9639775", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-DDI-76061", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-SCE-6782210", "R-HSA-9918481", "R-RNO-6803529", "R-SCE-72203", "R-SCE-6796648", "R-SPO-72203", "R-RNO-72086", "R-SPO-77075", "R-RNO-73772", "R-RNO-6782135", "R-SCE-113418", "R-SCE-72086", "R-MMU-73863", "R-RNO-5250924", "R-HSA-6782135", "R-HSA-73762", "R-CEL-77075", "R-SCE-77075", "R-HSA-5250924", "R-DDI-75953", "R-SPO-6782135", "R-CEL-73762", "R-DME-73772", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-DME-76061:r:RNA 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"R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-72086:r:mRNA Capping", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and 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"R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-9770562:r:mRNA Polyadenylation", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-RNO-9770562:r:mRNA Polyadenylation", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", 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"R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III 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"R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", 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(decarboxylating) activity:F", "GO:0006098:pentose-phosphate shunt:P"], "name": "6PGDH_Gnd/GntZ", "pathway_ids": ["R-MMU-71336", "R-HSA-71336", "R-DDI-71336", "R-DME-71336", "R-RNO-71336", "R-CEL-71336", "R-SPO-71336", "R-HSA-9818028", "R-SCE-71336"], "pathways": ["R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-DDI-71336:r:Pentose phosphate pathway", "R-DME-71336:r:Pentose phosphate pathway", "R-RNO-71336:r:Pentose phosphate pathway", "R-CEL-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-SCE-71336:r:Pentose phosphate pathway"], "type": "Family"}, "IPR006114": {"description": "6-phosphogluconate dehydrogenase, C-terminal", "go_ids": ["GO:0004616", "GO:0006098"], "go_terms": ["GO:0004616:phosphogluconate dehydrogenase (decarboxylating) activity:F", "GO:0006098:pentose-phosphate shunt:P"], "name": "6PGDH_C", "pathway_ids": ["R-MMU-71336", "R-HSA-71336", "R-DDI-71336", "R-DME-71336", "R-RNO-71336", "R-CEL-71336", "R-SPO-71336", "R-HSA-9818028", "R-SCE-71336"], "pathways": ["R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-DDI-71336:r:Pentose phosphate pathway", "R-DME-71336:r:Pentose phosphate pathway", "R-RNO-71336:r:Pentose phosphate pathway", "R-CEL-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-SCE-71336:r:Pentose phosphate pathway"], "type": "Domain"}, "IPR006115": {"description": "6-phosphogluconate dehydrogenase, NADP-binding", "go_ids": ["GO:0050661"], "go_terms": ["GO:0050661:NADP binding:F"], "name": "6PGDH_NADP-bd", "pathway_ids": ["R-MMU-71336", "R-HSA-71336", "R-BTA-70895", "R-MMU-70895", "R-CEL-70895", "R-DDI-71336", "R-DDI-70895", "R-HSA-70895", "R-DME-71336", "R-DME-70895", "R-RNO-71336", "R-CEL-71336", "R-SPO-71336", "R-HSA-9818028", "R-SCE-71336", "R-RNO-70895"], "pathways": ["R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-DDI-71336:r:Pentose phosphate pathway", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-DME-71336:r:Pentose phosphate pathway", "R-DME-70895:r:Branched-chain amino acid catabolism", "R-RNO-71336:r:Pentose phosphate pathway", "R-CEL-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-SCE-71336:r:Pentose phosphate pathway", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Domain"}, "IPR006118": {"description": "Recombinase, conserved site", "go_ids": ["GO:0000150", "GO:0006310"], "go_terms": ["GO:0000150:DNA strand exchange activity:F", "GO:0006310:DNA recombination:P"], "name": "Recombinase_CS", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR006119": {"description": "Resolvase, N-terminal catalytic domain", "go_ids": ["GO:0000150", "GO:0003677", "GO:0006310"], "go_terms": ["GO:0000150:DNA strand exchange activity:F", "GO:0003677:DNA binding:F", "GO:0006310:DNA recombination:P"], "name": "Resolv_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006120": {"description": "Resolvase, HTH domain", "go_ids": ["GO:0000150", "GO:0003677", "GO:0006310"], "go_terms": ["GO:0000150:DNA strand exchange activity:F", "GO:0003677:DNA binding:F", "GO:0006310:DNA recombination:P"], "name": "Resolvase_HTH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006121": {"description": "Heavy metal-associated domain, HMA", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "HMA_dom", "pathway_ids": ["R-DDI-3299685", "R-HSA-3299685", "R-SCE-3299685", "R-RNO-6803544", "R-CFA-6803544", "R-HSA-6803544", "R-MMU-6803544", "R-SPO-936837", "R-HSA-936837", "R-MMU-936837", "R-MMU-3299685", "R-RNO-3299685", "R-RNO-936837", "R-SCE-936837"], "pathways": ["R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-6803544:r:Ion influx/efflux at host-pathogen interface", "R-CFA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-MMU-6803544:r:Ion influx/efflux at host-pathogen interface", "R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases"], "type": "Domain"}, "IPR006122": {"description": "Heavy metal-associated domain, copper ion-binding", "go_ids": ["GO:0005507"], "go_terms": ["GO:0005507:copper ion binding:F"], "name": "HMA_Cu_ion-bd", "pathway_ids": ["R-HSA-3299685", "R-RNO-6803544", "R-HSA-6803544", "R-MMU-6803544", "R-HSA-936837", "R-MMU-936837", "R-RNO-936837", "R-SCE-936837"], "pathways": ["R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-MMU-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases"], "type": "Domain"}, "IPR006123": {"description": "Staphylococcal/Streptococcal toxin, beta-grasp domain", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Toxin_b-grasp_Staph/Strep", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006124": {"description": "Metalloenzyme", "go_ids": ["GO:0003824", "GO:0046872"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0046872:metal ion binding:F"], "name": "Metalloenzyme", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006127": {"description": "Periplasmic solute binding protein, ZnuA-like", "go_ids": ["GO:0030001", "GO:0046872"], "go_terms": ["GO:0030001:metal ion transport:P", "GO:0046872:metal ion binding:F"], "name": "ZnuA-like", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR006131": {"description": "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain", "go_ids": ["GO:0006520", "GO:0016597", "GO:0016743"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0016597:amino acid binding:F", "GO:0016743:carboxyl- or carbamoyltransferase activity:F"], "name": "Asp_carbamoyltransf_Asp/Orn-bd", "pathway_ids": ["PWY-7791", "PWY-5686", "PWY-7790", "R-MMU-500753", "R-SPO-70635", "R-HSA-500753", "R-GGA-70635", "R-SCE-500753", "R-SPO-500753", "R-GGA-1268020", "R-HSA-70635", "R-DDI-500753", "R-SPO-1268020", "R-RNO-70635", "R-MMU-70635", "R-HSA-9956553", "R-DME-500753", "R-GGA-187630", "R-HSA-1268020", "R-MMU-1268020", "R-CEL-500753", "R-HSA-9956551", "R-SCE-1268020", "R-SCE-70635", "R-RNO-1268020"], "pathways": ["PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "R-MMU-500753:r:Pyrimidine biosynthesis", "R-SPO-70635:r:Urea cycle", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-GGA-70635:r:Urea cycle", "R-SCE-500753:r:Pyrimidine biosynthesis", "R-SPO-500753:r:Pyrimidine biosynthesis", "R-GGA-1268020:r:Mitochondrial protein import", "R-HSA-70635:r:Urea cycle", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-SPO-1268020:r:Mitochondrial protein import", "R-RNO-70635:r:Urea cycle", "R-MMU-70635:r:Urea cycle", "R-HSA-9956553:r:OTC main chain variants cause OTC deficiency", "R-DME-500753:r:Pyrimidine biosynthesis", "R-GGA-187630:r:Arginine metabolism", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-1268020:r:Mitochondrial protein import", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-HSA-9956551:r:OTC leader sequence variants cause OTC deficiency", "R-SCE-1268020:r:Mitochondrial protein import", "R-SCE-70635:r:Urea cycle", "R-RNO-1268020:r:Mitochondrial protein import"], "type": "Domain"}, "IPR006132": {"description": "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding", "go_ids": ["GO:0006520", "GO:0016743"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0016743:carboxyl- or carbamoyltransferase activity:F"], "name": "Asp/Orn_carbamoyltranf_P-bd", "pathway_ids": ["PWY-7791", "PWY-5686", "PWY-7790", "R-MMU-500753", "R-SPO-70635", "R-HSA-500753", "R-GGA-70635", "R-SCE-500753", "R-SPO-500753", "R-GGA-1268020", "R-HSA-70635", "R-DDI-500753", "R-SPO-1268020", "R-RNO-70635", "R-MMU-70635", "R-HSA-9956553", "R-DME-500753", "R-GGA-187630", "R-HSA-1268020", "R-MMU-1268020", "R-CEL-500753", "R-HSA-9956551", "R-SCE-1268020", "R-SCE-70635", "R-RNO-1268020"], "pathways": ["PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "R-MMU-500753:r:Pyrimidine biosynthesis", "R-SPO-70635:r:Urea cycle", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-GGA-70635:r:Urea cycle", "R-SCE-500753:r:Pyrimidine biosynthesis", "R-SPO-500753:r:Pyrimidine biosynthesis", "R-GGA-1268020:r:Mitochondrial protein import", "R-HSA-70635:r:Urea cycle", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-SPO-1268020:r:Mitochondrial protein import", "R-RNO-70635:r:Urea cycle", "R-MMU-70635:r:Urea cycle", "R-HSA-9956553:r:OTC main chain variants cause OTC deficiency", "R-DME-500753:r:Pyrimidine biosynthesis", "R-GGA-187630:r:Arginine metabolism", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-1268020:r:Mitochondrial protein import", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-HSA-9956551:r:OTC leader sequence variants cause OTC deficiency", "R-SCE-1268020:r:Mitochondrial protein import", "R-SCE-70635:r:Urea cycle", "R-RNO-1268020:r:Mitochondrial protein import"], "type": "Domain"}, "IPR006133": {"description": "DNA-directed DNA polymerase, family B, exonuclease domain", "go_ids": [], "go_terms": [], "name": "DNA-dir_DNA_pol_B_exonuc", "pathway_ids": ["R-DME-110314", "R-CEL-69091", "R-RNO-174437", "R-HSA-174414", "R-SPO-5656169", "R-SCE-69091", "R-HSA-5696397", "R-MMU-174417", "R-SPO-5656121", "R-DDI-6782210", "R-CEL-69166", "R-RNO-110314", "R-DME-5656121", "R-HSA-5655862", "R-DME-113501", "R-RNO-69183", "R-MMU-110314", "R-DME-68962", "R-HSA-174417", "R-CEL-110314", "R-MMU-174414", "R-DDI-68952", "R-RNO-5696397", "R-SPO-69091", "R-DDI-68962", "R-DME-5655862", "R-DME-69183", "R-MMU-174437", "R-RNO-5656169", "R-HSA-5656121", "R-MMU-5358606", "R-DME-6782135", "R-SCE-68952", "R-SPO-69166", 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"R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-110312:r:Translesion synthesis by REV1", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5358606:r:Mismatch repair (MMR) 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"R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-4641265:r:Repression of WNT target genes", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-977347:r:Serine metabolism", "R-HSA-5339700:r:Signaling by TCF7L2 mutants", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-RNO-3899300:r:SUMOylation of transcription cofactors"], "type": "Domain"}, "IPR006140": {"description": "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain", "go_ids": ["GO:0051287"], "go_terms": ["GO:0051287:NAD binding:F"], "name": "D-isomer_DH_NAD-bd", "pathway_ids": ["R-MMU-3769402", "R-BTA-4641265", "R-RNO-4641265", "R-MMU-977347", "R-HSA-3769402", "R-MMU-3899300", "R-HSA-4641265", "R-RNO-977347", "R-SSC-977347", "R-MMU-4641265", "R-CEL-4641265", "R-BTA-9764725", "R-DDI-389661", "R-HSA-9764725", "R-DME-4641265", "R-MMU-9764725", "R-HSA-389661", "R-HSA-977347", "R-HSA-5339700", "R-CEL-3769402", "R-DME-3769402", "R-RNO-9764725", "R-HSA-9662360", "R-CEL-9764725", "R-DME-3899300", "R-DME-9764725", "R-MMU-389661", "R-RNO-3769402", "R-HSA-3899300", "R-RNO-3899300"], "pathways": ["R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-BTA-4641265:r:Repression of WNT target genes", "R-RNO-4641265:r:Repression of WNT target genes", "R-MMU-977347:r:Serine metabolism", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4641265:r:Repression of WNT target genes", "R-RNO-977347:r:Serine metabolism", "R-SSC-977347:r:Serine metabolism", "R-MMU-4641265:r:Repression of WNT target genes", "R-CEL-4641265:r:Repression of WNT target genes", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DDI-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-4641265:r:Repression of WNT target genes", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-977347:r:Serine metabolism", "R-HSA-5339700:r:Signaling by TCF7L2 mutants", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-RNO-3899300:r:SUMOylation of transcription cofactors"], "type": "Domain"}, "IPR006141": {"description": "Intein N-terminal splicing region", "go_ids": ["GO:0016539"], "go_terms": ["GO:0016539:intein-mediated protein splicing:P"], "name": "Intein_N", "pathway_ids": ["R-HSA-373080", "R-DDI-76066", "R-SCE-9639288", "R-DME-5362798", "R-DRE-2467813", "R-DRE-141444", "R-DME-209338", "R-MMU-5632681", "R-HSA-5362798", "R-HSA-5632681", "R-DDI-76061", "R-MMU-5358346", "R-HSA-5362768", "R-HSA-9796292", "R-RNO-5362798", "R-DRE-5663220", "R-SCE-917977", "R-SCE-1222556", "R-DRE-5358346", "R-SCE-77387", "R-MMU-5635838", "R-DRE-2500257", "R-HSA-9937080", "R-RNO-5632681", "R-HSA-5632684", "R-DRE-5362798", "R-DME-5632681", "R-DME-209471", "R-DRE-5632681", "R-MMU-5362798", "R-HSA-5635838", "R-HSA-9758920", "R-HSA-5658034", "R-RNO-5358346", "R-HSA-5358346", "R-DME-5358346", "R-HSA-8941284"], "pathways": ["R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-5362798:r:Release of Hh-Np from the secreting cell", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-5632681:r:Ligand-receptor interactions", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-9796292:r:Formation of axial mesoderm", "R-RNO-5362798:r:Release of Hh-Np from the secreting cell", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-SCE-77387:r:Insulin receptor recycling", "R-MMU-5635838:r:Activation of SMO", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-DME-5632681:r:Ligand-receptor interactions", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-DRE-5632681:r:Ligand-receptor interactions", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-5635838:r:Activation of SMO", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-5658034:r:HHAT G278V doesn't palmitoylate Hh-Np", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation"], "type": "PTM"}, "IPR006143": {"description": "RND efflux pump, membrane fusion protein", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "RND_pump_MFP", "pathway_ids": ["R-HSA-9913143", "R-HSA-9760173", "R-HSA-9638334"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-9638334:r:Iron assimilation using enterobactin"], "type": "Family"}, "IPR006145": {"description": "Pseudouridine synthase, RsuA/RluA-like", "go_ids": ["GO:0001522", "GO:0003723", "GO:0009451", "GO:0009982"], "go_terms": ["GO:0001522:pseudouridine synthesis:P", "GO:0003723:RNA binding:F", "GO:0009451:RNA modification:P", "GO:0009982:pseudouridine synthase activity:F"], "name": "PsdUridine_synth_RsuA/RluA", "pathway_ids": ["R-HSA-9937008", "R-HSA-6793080"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Domain"}, "IPR006148": {"description": "Glucosamine/galactosamine-6-phosphate isomerase", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "Glc/Gal-6P_isomerase", "pathway_ids": ["PWY-5514", "PWY-6906", "PWY-6855", "R-XTR-70171", "R-MMU-71336", "R-HSA-71336", "R-MMU-70171", "R-PFA-5628897", "R-BTA-70171", "R-DDI-71336", "R-PFA-71336", "R-DME-70171", "R-CEL-70171", "R-DDI-70171", "R-RNO-71336", "R-CEL-71336", "R-SPO-71336", "R-HSA-70171", "R-DME-71336", "R-SCE-71336"], "pathways": ["PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II", "PWY-6906:t:chitin derivatives degradation", "PWY-6855:t:chitin degradation I (archaea)", "R-XTR-70171:r:Glycolysis", "R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-MMU-70171:r:Glycolysis", "R-PFA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-70171:r:Glycolysis", "R-DDI-71336:r:Pentose phosphate pathway", "R-PFA-71336:r:Pentose phosphate pathway", "R-DME-70171:r:Glycolysis", "R-CEL-70171:r:Glycolysis", "R-DDI-70171:r:Glycolysis", "R-RNO-71336:r:Pentose phosphate pathway", "R-CEL-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-HSA-70171:r:Glycolysis", "R-DME-71336:r:Pentose phosphate pathway", "R-SCE-71336:r:Pentose phosphate pathway"], "type": "Domain"}, "IPR006149": {"description": "EB domain", "go_ids": [], "go_terms": [], "name": "EB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006150": {"description": "Cysteine-rich repeat", "go_ids": [], "go_terms": [], "name": "Cys_repeat_1", "pathway_ids": ["R-CEL-216083", "R-CEL-1474228", "R-CEL-2129379", "R-CEL-8957275", "R-CEL-1566948", "R-CEL-2173789", "R-CEL-381426"], "pathways": ["R-CEL-216083:r:Integrin cell surface interactions", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-1566948:r:Elastic fibre formation", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Repeat"}, "IPR006151": {"description": "Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase", "go_ids": [], "go_terms": [], "name": "Shikm_DH/Glu-tRNA_Rdtase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006153": {"description": "Cation/H+ exchanger, transmembrane domain", "go_ids": ["GO:0006812", "GO:0016020", "GO:0055085", "GO:0015297", "GO:1902600"], "go_terms": ["GO:0006812:monoatomic cation transport:P", "GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0015297:antiporter activity:F", "GO:1902600:proton transmembrane transport:P"], "name": "Cation/H_exchanger_TM", "pathway_ids": ["R-SPO-425986", "R-CEL-425986", "R-HSA-425986", "R-HSA-5619092", "R-BTA-425986", "R-HSA-2672351", "R-DDI-425986", "R-MMU-2160916", "R-HSA-2160916", "R-XTR-2672351", "R-MMU-2672351", "R-SCE-425986", "R-BTA-2160916", "R-MMU-425986", "R-RNO-425986", "R-HSA-5619052", "R-RNO-2160916"], "pathways": ["R-SPO-425986:r:Sodium/Proton exchangers", "R-CEL-425986:r:Sodium/Proton exchangers", "R-HSA-425986:r:Sodium/Proton exchangers", "R-HSA-5619092:r:Defective SLC9A6 causes X-linked, syndromic mental retardation, Christianson type (MRXSCH)", "R-BTA-425986:r:Sodium/Proton exchangers", "R-HSA-2672351:r:Stimuli-sensing channels", "R-DDI-425986:r:Sodium/Proton exchangers", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-2160916:r:Hyaluronan degradation", "R-XTR-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-SCE-425986:r:Sodium/Proton exchangers", "R-BTA-2160916:r:Hyaluronan degradation", "R-MMU-425986:r:Sodium/Proton exchangers", "R-RNO-425986:r:Sodium/Proton exchangers", "R-HSA-5619052:r:Defective SLC9A9 causes autism 16 (AUTS16)", "R-RNO-2160916:r:Hyaluronan degradation"], "type": "Domain"}, "IPR006155": {"description": "Josephin domain", "go_ids": ["GO:0016579", "GO:0004843"], "go_terms": ["GO:0016579:protein deubiquitination:P", "GO:0004843:cysteine-type deubiquitinase activity:F"], "name": "Josephin", "pathway_ids": ["R-HSA-9615017", "R-MMU-5689877", "R-RNO-5689877", "R-CEL-9615017", "R-MMU-9615017", "R-RNO-9615017", "R-DME-5689877", "R-GGA-9615017", "R-HSA-5689877", "R-CEL-5689877", "R-GGA-5689877"], "pathways": ["R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-5689877:r:Josephin domain DUBs", "R-RNO-5689877:r:Josephin domain DUBs", "R-CEL-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-RNO-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-DME-5689877:r:Josephin domain DUBs", "R-GGA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-5689877:r:Josephin domain DUBs", "R-CEL-5689877:r:Josephin domain DUBs", "R-GGA-5689877:r:Josephin domain DUBs"], "type": "Domain"}, "IPR006156": {"description": "Dihydroneopterin aldolase", "go_ids": ["GO:0004150", "GO:0006760"], "go_terms": ["GO:0004150:dihydroneopterin aldolase activity:F", "GO:0006760:folic acid-containing compound metabolic process:P"], "name": "Dihydroneopterin_aldolase", "pathway_ids": ["PWY-6147", "PWY-6148", "PWY-6797", "PWY-7539"], "pathways": ["PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)"], "type": "Family"}, "IPR006157": {"description": "Dihydroneopterin aldolase/epimerase domain", "go_ids": ["GO:0004150", "GO:0006760"], "go_terms": ["GO:0004150:dihydroneopterin aldolase activity:F", "GO:0006760:folic acid-containing compound metabolic process:P"], "name": "FolB_dom", "pathway_ids": ["PWY-6147", "PWY-6148", "PWY-6797", "PWY-7539"], "pathways": ["PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)"], "type": "Domain"}, "IPR006158": {"description": "Cobalamin (vitamin B12)-binding domain", "go_ids": ["GO:0031419", "GO:0046872"], "go_terms": ["GO:0031419:cobalamin binding:F", "GO:0046872:metal ion binding:F"], "name": "Cobalamin-bd", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-MMU-9013407", "R-CEL-71032", "R-CEL-9759218", "R-RNO-9759218", "R-RNO-9013407", "R-HSA-3359475", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-HSA-3359478", "R-DDI-1614635", "R-HSA-71032", "R-MMU-9759218", "R-MMU-1614635", "R-HSA-156581", "R-HSA-9759218", "R-MMU-71032", "R-HSA-3359467", "R-RNO-156581", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-3359475:r:Defective MMAA causes MMA, cblA type", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-3359478:r:Defective MUT causes MMAM", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-RNO-156581:r:Methylation", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Domain"}, "IPR006159": {"description": "Methylmalonyl-CoA mutase, C-terminal", "go_ids": ["GO:0016853"], "go_terms": ["GO:0016853:isomerase activity:F"], "name": "Acid_CoA_mut_C", "pathway_ids": ["R-HSA-3359475", "R-HSA-9759218", "R-MMU-71032", "R-HSA-3359478", "R-CEL-71032", "R-CEL-9759218", "R-HSA-71032", "R-MMU-9759218"], "pathways": ["R-HSA-3359475:r:Defective MMAA causes MMA, cblA type", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-3359478:r:Defective MUT causes MMAM", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism"], "type": "Domain"}, "IPR006160": {"description": "Short chain fatty acid transporter AtoE", "go_ids": [], "go_terms": [], "name": "SCFA_transpt_AtoE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006161": {"description": "Putative short-chain fatty acid transporter", "go_ids": [], "go_terms": [], "name": "AtoE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006164": {"description": "Ku70/Ku80, DNA-binding domain", "go_ids": ["GO:0003677", "GO:0006303"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006303:double-strand break repair via nonhomologous end joining:P"], "name": "DNA_bd_Ku70/Ku80", "pathway_ids": ["R-HSA-3270619", "R-HSA-6798695", "R-SPO-6798695", "R-HSA-5693571", "R-DDI-6798695", "R-GGA-353423", "R-DME-6798695", "R-DDI-5693571", "R-HSA-1834949", "R-SCE-6798695", "R-MMU-6798695", "R-MMU-5693571", "R-HSA-164843"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-6798695:r:Neutrophil degranulation", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Domain"}, "IPR006165": {"description": "Ku70", "go_ids": ["GO:0003677", "GO:0005634", "GO:0006303", "GO:0042162", "GO:0043564", "GO:0003684", "GO:0000723"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006303:double-strand break repair via nonhomologous end joining:P", "GO:0042162:telomeric repeat DNA binding:F", "GO:0043564:Ku70:Ku80 complex:C", "GO:0003684:damaged DNA binding:F", "GO:0000723:telomere maintenance:P"], "name": "Ku70", "pathway_ids": ["R-HSA-3270619", "R-HSA-6798695", "R-SPO-6798695", "R-HSA-5693571", "R-DDI-6798695", "R-GGA-353423", "R-DME-6798695", "R-DDI-5693571", "R-HSA-1834949", "R-SCE-6798695", "R-MMU-6798695", "R-MMU-5693571", "R-HSA-164843"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-6798695:r:Neutrophil degranulation", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Family"}, "IPR006166": {"description": "ERCC4 domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "ERCC4_domain", "pathway_ids": ["R-DDI-6782135", "R-DDI-5696395", "R-SCE-5693568", "R-MMU-6782135", "R-SPO-5693568", "R-HSA-9833482", "R-DME-5696395", "R-HSA-6782135", "R-HSA-6783310", "R-MMU-5685938", "R-MMU-6783310", "R-DRE-6783310", "R-DRE-5693568", "R-SPO-5696395", "R-MMU-9833482", "R-MMU-5696395", "R-XTR-5693568", "R-SPO-5696400", "R-DME-5696400", "R-HSA-5696395", "R-RNO-5693568", "R-HSA-5696400", "R-MMU-5696400", "R-MMU-5693568", "R-HSA-5693568", "R-SPO-6782135", "R-DME-6782135", "R-HSA-5685938", "R-RNO-6783310", "R-SCE-6782135"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9833482:r:PKR-mediated signaling", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-XTR-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Domain"}, "IPR006167": {"description": "DNA repair protein XPF", "go_ids": ["GO:0006281", "GO:0004520", "GO:0003697"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0004520:DNA endonuclease activity:F", "GO:0003697:single-stranded DNA binding:F"], "name": "XPF", "pathway_ids": ["R-SPO-5696395", "R-MMU-5696395", "R-MMU-5685938", "R-DME-5696400", "R-SPO-5696400", "R-MMU-6782135", "R-HSA-5696395", "R-HSA-5685938", "R-HSA-5696400", "R-DME-5696395", "R-SPO-6782135", "R-HSA-6782135", "R-DME-6782135", "R-HSA-6783310", "R-MMU-5696400", "R-SCE-6782135", "R-MMU-6783310"], "pathways": ["R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR006168": {"description": "Glycerol-3-phosphate dehydrogenase, NAD-dependent", "go_ids": ["GO:0006072"], "go_terms": ["GO:0006072:glycerol-3-phosphate metabolic process:P"], "name": "G3P_DH_NAD-dep", "pathway_ids": ["PWY-5981", "PWY-7902", "PWY-5667", "R-MMU-1483166", "R-DRE-1483166", "R-SPO-1483166", "R-RNO-1483166", "R-CEL-1483166", "R-XTR-1483166", "R-HSA-1483166", "R-SCE-1483166", "R-DME-1483166"], "pathways": ["PWY-5981:t:CDP-diacylglycerol biosynthesis III", "PWY-7902:t:glucosylglycerol biosynthesis", "PWY-5667:t:CDP-diacylglycerol biosynthesis I", "R-MMU-1483166:r:Synthesis of PA", "R-DRE-1483166:r:Synthesis of PA", "R-SPO-1483166:r:Synthesis of PA", "R-RNO-1483166:r:Synthesis of PA", "R-CEL-1483166:r:Synthesis of PA", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-1483166:r:Synthesis of PA", "R-SCE-1483166:r:Synthesis of PA", "R-DME-1483166:r:Synthesis of PA"], "type": "Family"}, "IPR006169": {"description": "GTP1/OBG domain", "go_ids": [], "go_terms": [], "name": "GTP1_OBG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006170": {"description": "Pheromone/general odorant binding protein", "go_ids": ["GO:0005549"], "go_terms": ["GO:0005549:odorant binding:F"], "name": "PBP/GOBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006171": {"description": "TOPRIM domain", "go_ids": [], "go_terms": [], "name": "TOPRIM_dom", "pathway_ids": ["R-HSA-9913143", "R-RNO-4615885", "R-HSA-9638771", "R-DDI-5693616", "R-SCE-4615885", "R-SPO-4615885", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-HSA-9701192", "R-MMU-4615885", "R-DDI-4615885", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-1362277", "R-HSA-9704331", "R-HSA-912446", "R-DME-4615885", "R-DDI-5693607", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-4615885", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-CEL-4615885", "R-HSA-9913635"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9638771:r:Action of antimicrobials", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR006172": {"description": "DNA-directed DNA polymerase, family B", "go_ids": ["GO:0000166", "GO:0003676", "GO:0003887"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0003676:nucleic acid binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F"], "name": "DNA-dir_DNA_pol_B", "pathway_ids": ["R-DME-110314", "R-CEL-69091", "R-RNO-174437", "R-HSA-174414", "R-SPO-5656169", "R-SCE-69091", "R-HSA-5696397", "R-MMU-174417", "R-SPO-5656121", "R-DDI-6782210", "R-CEL-69166", "R-RNO-110314", "R-DME-5656121", "R-HSA-5655862", "R-DME-113501", "R-RNO-69183", "R-MMU-110314", "R-DME-68962", "R-HSA-174417", "R-CEL-110314", "R-MMU-174414", "R-DDI-68952", "R-RNO-5696397", "R-SPO-69091", "R-DDI-68962", "R-DME-5655862", "R-DME-69183", "R-MMU-174437", "R-RNO-5656169", "R-HSA-5656121", "R-MMU-5358606", "R-DME-6782135", "R-SCE-68952", "R-SPO-69166", "R-MMU-5358565", "R-RNO-6782210", "R-HSA-9610379", "R-DME-5651801", "R-HSA-68952", "R-SCE-69183", "R-DDI-113501", "R-MMU-68962", "R-MMU-5651801", "R-RNO-174430", "R-HSA-174430", "R-DDI-69183", "R-DME-69091", "R-CEL-6782210", "R-HSA-110312", "R-HSA-9609690", "R-MMU-69183", "R-HSA-9710421", "R-RNO-113501", "R-SPO-68952", "R-SPO-110314", "R-SCE-69166", "R-CEL-6782135", "R-MMU-6782210", "R-CEL-5651801", "R-SCE-110312", "R-MMU-174411", "R-MMU-5696397", "R-RNO-174414", "R-SCE-6782135", "R-HSA-110314", "R-SPO-5651801", "R-DDI-6782135", "R-MMU-174430", "R-RNO-68962", "R-HSA-5685942", "R-HSA-69205", "R-MMU-6782135", "R-SPO-5655862", "R-HSA-5358606", "R-MMU-110312", "R-SPO-110312", "R-RNO-69166", "R-CEL-69183", "R-DME-110312", "R-HSA-68962", "R-DME-68952", "R-HSA-6782210", "R-CEL-5656169", "R-RNO-68952", "R-HSA-5656169", "R-RNO-174411", "R-MMU-5696400", "R-MMU-5655862", "R-HSA-113501", "R-RNO-5358606", "R-HSA-2564830", "R-SPO-5696397", "R-RNO-5358565", "R-DDI-69091", "R-RNO-6782135", "R-SPO-69183", "R-MMU-113501", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-174411", "R-HSA-69166", "R-HSA-5651801", "R-SCE-68962", "R-SCE-113501", "R-CEL-5696397", "R-DDI-69166", "R-RNO-69091", "R-RNO-5685942", "R-MMU-68952", "R-DME-5656169", "R-MMU-5656121", "R-SPO-113501", "R-SPO-5696400", "R-DME-5696400", "R-SPO-6782210", "R-HSA-69183", "R-MMU-69166", "R-RNO-5696400", "R-RNO-174417", "R-SPO-68962", "R-HSA-5696400", "R-HSA-69091", "R-HSA-5358565", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-69091:r:Polymerase switching", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SCE-69091:r:Polymerase switching", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-5656121:r:Translesion synthesis by POLI", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-68962:r:Activation of the pre-replicative complex", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-DDI-68952:r:DNA replication initiation", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SPO-69091:r:Polymerase switching", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-68952:r:DNA replication initiation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9610379:r:HCMV Late Events", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-68952:r:DNA replication initiation", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-DME-69091:r:Polymerase switching", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110312:r:Translesion synthesis by REV1", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-HSA-9710421:r:Defective pyroptosis", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-68952:r:DNA replication initiation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-110312:r:Translesion synthesis by REV1", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5656169:r:Termination of translesion DNA synthesis", "R-RNO-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-69091:r:Polymerase switching", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-69166:r:Removal of the Flap Intermediate", "R-RNO-69091:r:Polymerase switching", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-68952:r:DNA replication initiation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-69091:r:Polymerase switching", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Family"}, "IPR006173": {"description": "Staphylococcal/Streptococcal toxin, OB-fold", "go_ids": ["GO:0090729"], "go_terms": ["GO:0090729:toxin activity:F"], "name": "Staph_tox_OB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006175": {"description": "YjgF/YER057c/UK114 family", "go_ids": [], "go_terms": [], "name": "YjgF/YER057c/UK114", "pathway_ids": ["R-HSA-8849175", "R-SPO-5358493", "R-MMU-8849175", "R-BTA-8849175", "R-SCE-5358493", "R-DME-8849175", "R-CEL-8849175", "R-RNO-8849175"], "pathways": ["R-HSA-8849175:r:Threonine catabolism", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-8849175:r:Threonine catabolism", "R-BTA-8849175:r:Threonine catabolism", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-DME-8849175:r:Threonine catabolism", "R-CEL-8849175:r:Threonine catabolism", "R-RNO-8849175:r:Threonine catabolism"], "type": "Family"}, "IPR006176": {"description": "3-hydroxyacyl-CoA dehydrogenase, NAD binding", "go_ids": ["GO:0006631", "GO:0070403"], "go_terms": ["GO:0006631:fatty acid metabolic process:P", "GO:0070403:NAD+ binding:F"], "name": "3-OHacyl-CoA_DH_NAD-bd", "pathway_ids": ["PWY-8182", "PWY-7007", "PWY-7401", "PWY-8354", "PWY-6435", "PWY-6443", "PWY-6583", "PWY-6946", "PWY-8181", "PWY-6945", "PWY-6458", "PWY-6446", "PWY-8152", "PWY-7726", "PWY-6944", "PWY-6863", "PWY-5789", "PWY-7654", "PWY-5136", "PWY-1361", "PWY-7778", "PWY-7656", "PWY-7216", "PWY-5138", "PWY-8347", "PWY-6883", "PWY-7094", "PWY-8179", "PWY-7606", "PWY-5177", "PWY-7779", "R-RNO-1482798", "R-RNO-77352", "R-RNO-5661270", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-CEL-77348", "R-DRE-390247", "R-CEL-77350", "R-RNO-77310", "R-HSA-77350", "R-HSA-77285", "R-HSA-77346", "R-MMU-77352", "R-SSC-77346", "R-RNO-77305", "R-HSA-5661270", "R-SSC-77310", "R-RNO-9033241", "R-MMU-77346", "R-RNO-77350", "R-RNO-77285", "R-MMU-5661270", "R-MMU-77310", "R-RNO-77348", "R-MMU-1482798", "R-HSA-77305", "R-HSA-9837999", "R-SSC-77305", "R-HSA-77352", "R-CEL-77346", "R-SSC-77352", "R-SSC-77348", "R-CEL-9837999", "R-SSC-77350", "R-CEL-77352", "R-MMU-77350", "R-SSC-1482798", "R-HSA-77348", "R-CEL-77310", "R-MMU-77348", "R-MMU-9033241", "R-MMU-77285", "R-HSA-1482798", "R-RNO-9837999", "R-MMU-77305", "R-BTA-5661270", "R-HSA-77310", "R-SSC-77285", "R-HSA-390247", "R-MMU-390247", "R-SSC-9837999", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8354:t:adipate degradation", "PWY-6435:t:4-hydroxybenzoate biosynthesis III (plants)", "PWY-6443:t:benzoate biosynthesis I (CoA-dependent, beta-oxidative)", "PWY-6583:t:pyruvate fermentation to butanol I", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "PWY-6945:t:cholesterol 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"R-SSC-6811558", "R-MMU-389356", "R-MMU-9833482", "R-BTA-2995383", "R-BTA-2871809", "R-RNO-5625740", "R-CEL-2500257", "R-RNO-975957", "R-SPO-2500257", "R-HSA-5358749", "R-MMU-8939211", "R-HSA-2514859", "R-BTA-432142", "R-CEL-9833482", "R-HSA-9648025", "R-SCE-2500257", "R-HSA-5467340", "R-DME-350416", "R-SPO-389513", "R-RNO-113501", "R-RNO-389513", "R-HSA-2465910", "R-SPO-202670", "R-SSC-113501", "R-HSA-9860927", "R-SCE-198753", "R-MMU-69231", "R-HSA-5358751", "R-DDI-69273", "R-BTA-389356", "R-SSC-68877", "R-DDI-9770562", "R-DME-9860927", "R-DME-195253", "R-DME-209214", "R-DME-6811558", "R-HSA-2025928", "R-BTA-2467813", "R-SCE-975957", "R-MMU-5607763", "R-DME-2871809", "R-HSA-5339716", "R-DDI-389513", "R-DME-5607763", "R-MMU-9648025", "R-SSC-141444", "R-SSC-69273", "R-BTA-69273", "R-XTR-68877", "R-HSA-163560", "R-RNO-204005", "R-RNO-389356", "R-MMU-2871809", "R-BTA-389513", "R-XTR-2565942", "R-RNO-198753", "R-CFA-180024", "R-BTA-141444", "R-HSA-5627117", "R-HSA-5675221"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-SSC-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-SSC-9833482:r:PKR-mediated signaling", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-CEL-8939211:r:ESR-mediated signaling", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-4086398:r:Ca2+ pathway", "R-DDI-198753:r:ERK/MAPK targets", "R-XTR-5625740:r:RHO GTPases activate PKNs", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-HSA-202670:r:ERKs are inactivated", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-5673000:r:RAF activation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-202670:r:ERKs are inactivated", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-389356:r:Co-stimulation by CD28", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-BTA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5673000:r:RAF activation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CFA-9770562:r:mRNA Polyadenylation", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-202670:r:ERKs are inactivated", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DDI-9833482:r:PKR-mediated signaling", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DDI-69231:r:Cyclin D associated events in G1", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-198753:r:ERK/MAPK targets", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9833482:r:PKR-mediated signaling", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-BTA-202670:r:ERKs are inactivated", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-432142:r:Platelet sensitization by LDL", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-8939211:r:ESR-mediated signaling", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-DME-5673000:r:RAF activation", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-BTA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-SPO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-5673000:r:RAF activation", "R-BTA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SPO-198753:r:ERK/MAPK targets", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-180024:r:DARPP-32 events", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-180024:r:DARPP-32 events", "R-DME-4086398:r:Ca2+ pathway", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-209190:r:Phosphorylation of CI", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-DDI-202670:r:ERKs are inactivated", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-4086398:r:Ca2+ pathway", "R-BTA-180024:r:DARPP-32 events", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-BTA-2025928:r:Calcineurin activates NFAT", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-8939211:r:ESR-mediated signaling", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-5673000:r:RAF activation", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-4086398:r:Ca2+ pathway", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-2025928:r:Calcineurin activates NFAT", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-5673000:r:RAF activation", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-69231:r:Cyclin D associated events in G1", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5673000:r:RAF activation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-SSC-196299:r:Beta-catenin phosphorylation cascade", "R-SSC-5625740:r:RHO GTPases activate PKNs", "R-CEL-69231:r:Cyclin D associated events in G1", "R-RNO-5673000:r:RAF activation", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-198753:r:ERK/MAPK targets", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-DME-538898:r:Dephosphorylation of TIM", "R-SSC-389356:r:Co-stimulation by CD28", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-BTA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-SCE-202670:r:ERKs are inactivated", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-432142:r:Platelet sensitization by LDL", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-180024:r:DARPP-32 events", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-DME-432620:r:Dephosphorylation of PER", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-9833482:r:PKR-mediated signaling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-XTR-9770562:r:mRNA Polyadenylation", "R-SSC-202670:r:ERKs are inactivated", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-XTR-5627123:r:RHO GTPases activate PAKs", "R-DME-209396:r:Phosphorylation of ARM", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-HSA-68877:r:Mitotic Prometaphase", "R-SSC-5627123:r:RHO GTPases activate PAKs", "R-GGA-9770562:r:mRNA Polyadenylation", "R-HSA-4086398:r:Ca2+ pathway", "R-SSC-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-389513:r:Co-inhibition by CTLA4", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-432626:r:Circadian Clock pathway", "R-BTA-198753:r:ERK/MAPK targets", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-XTR-180024:r:DARPP-32 events", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69231:r:Cyclin D associated events in G1", "R-SCE-8939211:r:ESR-mediated signaling", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-SSC-9770562:r:mRNA Polyadenylation", "R-CEL-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-180024:r:DARPP-32 events", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-BTA-69231:r:Cyclin D associated events in G1", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-SSC-198753:r:ERK/MAPK targets", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-432142:r:Platelet sensitization by LDL", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-BTA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-8939211:r:ESR-mediated signaling", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-432142:r:Platelet sensitization by LDL", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-DME-350416:r:Regulation of non-muscle Myosin II", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-SPO-202670:r:ERKs are inactivated", "R-SSC-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SCE-198753:r:ERK/MAPK targets", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-389356:r:Co-stimulation by CD28", "R-SSC-68877:r:Mitotic Prometaphase", "R-DDI-9770562:r:mRNA Polyadenylation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-209214:r:Phosphorylation of SMO", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-DME-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-XTR-68877:r:Mitotic Prometaphase", "R-HSA-163560:r:Triglyceride catabolism", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-389356:r:Co-stimulation by CD28", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-198753:r:ERK/MAPK targets", "R-CFA-180024:r:DARPP-32 events", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR006187": {"description": "Claudin", "go_ids": ["GO:0005198", "GO:0005923"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0005923:bicellular tight junction:C"], "name": "Claudin", "pathway_ids": ["R-HSA-9918485", "R-HSA-9925563", "R-HSA-8935964", "R-HSA-420029"], "pathways": ["R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-HSA-420029:r:Tight junction interactions"], "type": "Family"}, "IPR006189": {"description": "CHASE domain", "go_ids": [], "go_terms": [], "name": "CHASE_dom", "pathway_ids": ["R-DDI-2514859"], "pathways": ["R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Domain"}, "IPR006194": {"description": "Glycine-tRNA synthetase, heterodimeric", "go_ids": ["GO:0000166", "GO:0004820", "GO:0005524", "GO:0005737", "GO:0006426"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004820:glycine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006426:glycyl-tRNA aminoacylation:P"], "name": "Gly-tRNA-synth_heterodimer", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006196": {"description": "RNA-binding domain, S1, IF1 type", "go_ids": ["GO:0003723", "GO:0003743", "GO:0006413"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003743:translation initiation factor activity:F", "GO:0006413:translational initiation:P"], "name": "RNA-binding_domain_S1_IF1", "pathway_ids": ["R-SPO-72702", "R-SCE-156827", "R-MMU-72702", "R-DDI-72702", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-MMU-72689", "R-HSA-72706", "R-HSA-72689", "R-HSA-156827", "R-DDI-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-72649", "R-HSA-72695", "R-MMU-156827", "R-MMU-72706", "R-SCE-72649", "R-SCE-72695", "R-MMU-72695", "R-SPO-156827", "R-DDI-156827", "R-SCE-72689", "R-SPO-72689", "R-SCE-72702"], "pathways": ["R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-72649:r:Translation initiation complex formation", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72702:r:Ribosomal scanning and start codon recognition"], "type": "Domain"}, "IPR006199": {"description": "LexA repressor, DNA-binding domain", "go_ids": ["GO:0004252", "GO:0006508"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "LexA_DNA-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006200": {"description": "Transcription regulator LexA", "go_ids": ["GO:0004252", "GO:0009432", "GO:0045892"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0009432:SOS response:P", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "LexA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006201": {"description": "Neurotransmitter-gated ion-channel", "go_ids": ["GO:0016020", "GO:0034220", "GO:0004888", "GO:0005216"], "go_terms": ["GO:0016020:membrane:C", "GO:0034220:monoatomic ion transmembrane transport:P", "GO:0004888:transmembrane signaling receptor activity:F", "GO:0005216:monoatomic ion channel activity:F"], "name": "Neur_channel", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-BTA-629597", "R-HSA-9667769", "R-DME-629594", "R-CEL-6798695", "R-HSA-977443", "R-GGA-977443", "R-BTA-112314", "R-DRE-629597", "R-BTA-629587", "R-CEL-112314", "R-HSA-629594", "R-RNO-112314", "R-RNO-629597", "R-MMU-112314", "R-MMU-629597", "R-DME-629587", "R-GGA-629587", "R-RNO-629594", "R-DRE-629594", "R-DME-6798695", "R-DME-977443", "R-RNO-629587", "R-GGA-629594", "R-DME-112314", "R-HSA-629587", "R-CEL-977443", "R-HSA-1236394", "R-CEL-629597", "R-GGA-629597", "R-BTA-977443", "R-CEL-629594", "R-DME-629597", "R-MMU-629587", "R-DRE-112314", "R-MMU-6798695", "R-MMU-977443", "R-BTA-629594", "R-HSA-112314", "R-CEL-629587", "R-MMU-629594", "R-HSA-629597", "R-RNO-977443"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-DME-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977443:r:GABA receptor activation", "R-GGA-977443:r:GABA receptor activation", "R-BTA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-DRE-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-CEL-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-RNO-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-RNO-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-MMU-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-DME-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-GGA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-RNO-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DRE-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-977443:r:GABA receptor activation", "R-RNO-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-GGA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-CEL-977443:r:GABA receptor activation", "R-HSA-1236394:r:Signaling by ERBB4", "R-CEL-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-GGA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-977443:r:GABA receptor activation", "R-CEL-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-MMU-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-DRE-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-977443:r:GABA receptor activation", "R-BTA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-CEL-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-MMU-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-RNO-977443:r:GABA receptor activation"], "type": "Family"}, "IPR006202": {"description": "Neurotransmitter-gated ion-channel ligand-binding domain", "go_ids": ["GO:0005230", "GO:0006811", "GO:0016020"], "go_terms": ["GO:0005230:extracellular ligand-gated monoatomic ion channel activity:F", "GO:0006811:monoatomic ion transport:P", "GO:0016020:membrane:C"], "name": "Neur_chan_lig-bd", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-BTA-629597", "R-HSA-9667769", "R-DME-629594", "R-CEL-6798695", "R-HSA-977443", "R-GGA-977443", "R-BTA-112314", "R-DRE-629597", "R-BTA-629587", "R-CEL-112314", "R-HSA-629594", "R-RNO-112314", "R-RNO-629597", "R-MMU-112314", "R-MMU-629597", "R-DME-629587", "R-GGA-629587", "R-RNO-629594", "R-DRE-629594", "R-DME-6798695", "R-DME-977443", "R-RNO-629587", "R-GGA-629594", "R-DME-112314", "R-HSA-629587", "R-CEL-977443", "R-HSA-1236394", "R-CEL-629597", "R-GGA-629597", "R-BTA-977443", "R-CEL-629594", "R-DME-629597", "R-MMU-629587", "R-DRE-112314", "R-MMU-6798695", "R-MMU-977443", "R-BTA-629594", "R-HSA-112314", "R-CEL-629587", "R-MMU-629594", "R-HSA-629597", "R-RNO-977443"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-DME-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977443:r:GABA receptor activation", "R-GGA-977443:r:GABA receptor activation", "R-BTA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-DRE-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-CEL-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-RNO-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-RNO-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-MMU-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-DME-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-GGA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-RNO-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DRE-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-977443:r:GABA receptor activation", "R-RNO-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-GGA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-CEL-977443:r:GABA receptor activation", "R-HSA-1236394:r:Signaling by ERBB4", "R-CEL-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-GGA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-977443:r:GABA receptor activation", "R-CEL-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-MMU-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-DRE-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-977443:r:GABA receptor activation", "R-BTA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-CEL-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-MMU-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-RNO-977443:r:GABA receptor activation"], "type": "Domain"}, "IPR006204": {"description": "GHMP kinase N-terminal domain", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "GHMP_kinase_N_dom", "pathway_ids": ["R-SCE-9969896", "R-HSA-5609976", "R-MMU-70370", "R-BTA-70370", "R-RNO-9969896", "R-HSA-70370", "R-BTA-9969896", "R-DDI-9969896", "R-MMU-6787639", "R-MMU-9969896", "R-CFA-70370", "R-HSA-2426168", "R-HSA-6787639", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-5609976:r:Defective GALK1 causes GALCT2", "R-MMU-70370:r:Galactose catabolism", "R-BTA-70370:r:Galactose catabolism", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-70370:r:Galactose catabolism", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-6787639:r:GDP-fucose biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-CFA-70370:r:Galactose catabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-6787639:r:GDP-fucose biosynthesis", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR006205": {"description": "Mevalonate kinase", "go_ids": ["GO:0004496", "GO:0005524", "GO:0005737", "GO:0008299"], "go_terms": ["GO:0004496:mevalonate kinase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0008299:isoprenoid biosynthetic process:P"], "name": "Mev_gal_kin", "pathway_ids": ["PWY-7391", "PWY-922", "PWY-6174", "PWY-8125", "R-SCE-9969896", "R-BTA-9969896", "R-DDI-9969896", "R-MMU-9969896", "R-RNO-9969896", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "PWY-6174:t:mevalonate pathway II (haloarchaea)", "PWY-8125:t:mevalonate pathway IV (archaea)", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR006206": {"description": "Mevalonate/galactokinase", "go_ids": ["GO:0005524", "GO:0005737", "GO:0016301", "GO:0016773"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0016301:kinase activity:F", "GO:0016773:phosphotransferase activity, alcohol group as acceptor:F"], "name": "Mevalonate/galactokinase", "pathway_ids": ["PWY-6527", "PWY-3821", "PWY-6317", "R-HSA-70370", "R-HSA-5609976", "R-MMU-70370", "R-CFA-70370", "R-BTA-70370"], "pathways": ["PWY-6527:t:stachyose degradation", "PWY-3821:t:D-galactose detoxification", "PWY-6317:t:D-galactose degradation I (Leloir pathway)", "R-HSA-70370:r:Galactose catabolism", "R-HSA-5609976:r:Defective GALK1 causes GALCT2", "R-MMU-70370:r:Galactose catabolism", "R-CFA-70370:r:Galactose catabolism", "R-BTA-70370:r:Galactose catabolism"], "type": "Family"}, "IPR006207": {"description": "Cystine knot, C-terminal", "go_ids": [], "go_terms": [], "name": "Cys_knot_C", "pathway_ids": ["R-HSA-2032785", "R-HSA-5083632", "R-HSA-5674135", "R-HSA-6802952", "R-MMU-76009", "R-HSA-140837", "R-HSA-9010553", "R-HSA-430116", "R-MMU-8957275", "R-HSA-9649948", "R-HSA-9846298", "R-MMU-381426", "R-HSA-5083625", "R-GGA-8957275", "R-HSA-9672391", "R-HSA-5621480", "R-HSA-6802955", "R-HSA-381426", "R-HSA-9672393", "R-HSA-6802948", "R-RNO-375281", "R-GGA-201451", "R-HSA-8951671", "R-MMU-140837", "R-HSA-9845619", "R-HSA-418555", "R-HSA-373752", "R-RNO-381426", "R-HSA-375281", "R-HSA-75892", "R-RNO-5173214", "R-MMU-376176", "R-MMU-5173214", "R-MMU-216083", "R-HSA-372708", "R-DME-9010553", "R-MMU-354192", "R-MMU-114608", "R-HSA-9656223", "R-HSA-201681", "R-MMU-5674135", "R-HSA-9845620", "R-HSA-977068", "R-MMU-913709", "R-MMU-430116", "R-HSA-201451", "R-MMU-9010553", "R-HSA-9845622", "R-HSA-9845621", "R-MMU-372708", "R-HSA-114608", "R-CEL-9010553", "R-HSA-76009", "R-HSA-1181150", "R-HSA-6802946", "R-RNO-8957275", "R-MMU-201451", "R-MMU-977068", "R-DME-428890", "R-GGA-381426", "R-DME-376176", "R-HSA-354192", "R-HSA-3772470", "R-HSA-5083636", "R-HSA-216083", "R-XTR-201451", "R-HSA-8985801", "R-HSA-5083635", "R-HSA-428542", "R-HSA-376176", "R-HSA-9662361", "R-HSA-9937080", "R-MMU-428890", "R-HSA-354194", "R-MMU-354194", "R-MMU-8985586", "R-MMU-375281", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-HSA-5173214", "R-HSA-428540", "R-HSA-8957275", "R-HSA-428890", "R-CEL-376176", "R-HSA-1433617", "R-MMU-418555", "R-HSA-913709"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-375281:r:Hormone ligand-binding receptors", "R-GGA-201451:r:Signaling by BMP", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-375281:r:Hormone ligand-binding receptors", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-376176:r:Signaling by ROBO receptors", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-201451:r:Signaling by BMP", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-1181150:r:Signaling by NODAL", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-201451:r:Signaling by BMP", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-376176:r:Signaling by ROBO receptors", "R-HSA-354192:r:Integrin signaling", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-216083:r:Integrin cell surface interactions", "R-XTR-201451:r:Signaling by BMP", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-375281:r:Hormone ligand-binding receptors", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-428540:r:Activation of RAC1", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Domain"}, "IPR006208": {"description": "Glycoprotein hormone subunit beta", "go_ids": [], "go_terms": [], "name": "Glyco_hormone_CN", "pathway_ids": ["R-HSA-2032785", "R-HSA-975578", "R-SSC-193993", "R-SSC-209968", "R-RNO-193993", "R-BTA-8866910", "R-BTA-375281", "R-RNO-193048", "R-MMU-8957275", "R-HSA-209968", "R-SSC-8866910", "R-GGA-209968", "R-RNO-8957275", "R-HSA-193993", "R-HSA-8866910", "R-GGA-209822", "R-MMU-381426", "R-GGA-8957275", "R-HSA-193048", "R-SSC-975578", "R-MMU-193048", "R-BTA-193993", "R-GGA-381426", "R-HSA-381426", "R-RNO-8866910", "R-RNO-209968", "R-GGA-375281", "R-RNO-375281", "R-HSA-8951671", "R-BTA-209968", "R-HSA-418555", "R-BTA-975578", "R-MMU-375281", "R-SSC-193048", "R-MMU-193993", "R-MMU-8866910", "R-SSC-375281", "R-BTA-193048", "R-HSA-375281", "R-HSA-209822", "R-SSC-209822", "R-GGA-418555", "R-RNO-381426", "R-BTA-418555", "R-MMU-209822", "R-RNO-209822", "R-MMU-209968", "R-HSA-8957275", "R-MMU-975578", "R-MMU-418555", "R-BTA-209822"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-SSC-193993:r:Mineralocorticoid biosynthesis", "R-SSC-209968:r:Thyroxine biosynthesis", "R-RNO-193993:r:Mineralocorticoid biosynthesis", "R-BTA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-375281:r:Hormone ligand-binding receptors", "R-RNO-193048:r:Androgen biosynthesis", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-209968:r:Thyroxine biosynthesis", "R-SSC-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-GGA-209968:r:Thyroxine biosynthesis", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-193993:r:Mineralocorticoid biosynthesis", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-GGA-209822:r:Glycoprotein hormones", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-193048:r:Androgen biosynthesis", "R-SSC-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-193048:r:Androgen biosynthesis", "R-BTA-193993:r:Mineralocorticoid biosynthesis", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-RNO-209968:r:Thyroxine biosynthesis", "R-GGA-375281:r:Hormone ligand-binding receptors", "R-RNO-375281:r:Hormone ligand-binding receptors", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-BTA-209968:r:Thyroxine biosynthesis", "R-HSA-418555:r:G alpha (s) signalling events", "R-BTA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-375281:r:Hormone ligand-binding receptors", "R-SSC-193048:r:Androgen biosynthesis", "R-MMU-193993:r:Mineralocorticoid biosynthesis", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-SSC-375281:r:Hormone ligand-binding receptors", "R-BTA-193048:r:Androgen biosynthesis", "R-HSA-375281:r:Hormone ligand-binding receptors", "R-HSA-209822:r:Glycoprotein hormones", "R-SSC-209822:r:Glycoprotein hormones", "R-GGA-418555:r:G alpha (s) signalling events", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-418555:r:G alpha (s) signalling events", "R-MMU-209822:r:Glycoprotein hormones", "R-RNO-209822:r:Glycoprotein hormones", "R-MMU-209968:r:Thyroxine biosynthesis", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-418555:r:G alpha (s) signalling events", "R-BTA-209822:r:Glycoprotein hormones"], "type": "Domain"}, "IPR006211": {"description": "Furin-like cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "Furin-like_Cys-rich_dom", "pathway_ids": ["R-MMU-1250342", "R-RNO-1306955", "R-MMU-8856828", "R-MMU-180336", "R-RNO-1250347", "R-MMU-6811558", "R-HSA-9665251", "R-HSA-77387", "R-RNO-74752", "R-RNO-2428933", "R-DME-9652282", "R-RNO-9009391", "R-MMU-9009391", "R-HSA-1306955", "R-RNO-9018519", "R-RNO-8863795", "R-HSA-8863795", "R-RNO-8847993", "R-RNO-6811558", "R-CEL-1257604", "R-RNO-1963642", "R-MMU-9652282", "R-MMU-1236394", "R-HSA-9013507", "R-DME-1251985", "R-CEL-182971", "R-MMU-5673001", "R-MMU-77387", "R-HSA-182971", "R-HSA-74713", "R-DME-6785631", "R-DME-212718", "R-DME-1253288", "R-HSA-9609690", "R-HSA-5637810", "R-HSA-9820960", "R-DME-416572", "R-DME-1257604", "R-MMU-179812", "R-MMU-1963642", "R-HSA-445144", "R-MMU-1250196", "R-DME-182971", "R-CEL-6811558", "R-DME-1963642", "R-HSA-179812", "R-CEL-8856825", "R-HSA-8857538", "R-HSA-5638303", "R-DME-180336", "R-DME-5673001", "R-DME-1358803", "R-HSA-416572", "R-CEL-1227986", "R-HSA-1251985", "R-RNO-1257604", "R-HSA-9665737", "R-HSA-9665348", "R-HSA-2428933", "R-CEL-2179392", "R-RNO-1253288", "R-MMU-8847993", "R-MMU-9013507", "R-MMU-1250347", "R-HSA-1963642", "R-HSA-1250196", "R-DME-8863795", "R-RNO-1251985", "R-HSA-1963640", "R-DME-1250342", "R-MMU-74713", "R-CEL-8856828", "R-HSA-9665249", "R-RNO-1250342", "R-DME-2179392", "R-MMU-1227986", "R-RNO-1227986", "R-HSA-6785631", "R-MMU-1257604", "R-HSA-9665250", "R-DME-177929", "R-HSA-1358803", "R-HSA-9634638", "R-HSA-74749", "R-HSA-180336", "R-RNO-74713", "R-CEL-77387", "R-MMU-1251985", "R-HSA-9009391", "R-MMU-212718", "R-CEL-179812", "R-HSA-9634285", "R-HSA-8856825", "R-HSA-74752", "R-CEL-9009391", "R-HSA-2428928", "R-MMU-74749", "R-MMU-1963640", "R-MMU-1253288", "R-MMU-6785631", "R-MMU-182971", "R-HSA-180292", "R-MMU-1306955", "R-HSA-8856828", "R-CEL-1253288", "R-CEL-9652282", "R-MMU-74752", "R-RNO-416572", "R-RNO-74749", "R-HSA-2179392", "R-HSA-9927418", "R-CEL-5673001", "R-MMU-416572", "R-HSA-177929", "R-MMU-74751", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-9652282", "R-RNO-5673001", "R-CEL-6785631", "R-HSA-9018519", "R-HSA-212718", "R-MMU-2428933", "R-RNO-2404192", "R-DME-1227986", "R-HSA-9665244", "R-HSA-9665686", "R-DME-1236394", "R-HSA-2404192", "R-MMU-180292", "R-HSA-8847993", "R-DME-9018519", "R-CEL-180292", "R-CEL-177929", "R-HSA-2219530", "R-MMU-445144", "R-RNO-77387", "R-CEL-1250196", "R-HSA-5673001", "R-HSA-6811558", "R-MMU-9018519", "R-CEL-212718", "R-DME-110478", "R-DME-445144", "R-HSA-9620244", "R-RNO-1358803", "R-DME-1250196", "R-HSA-1253288", "R-DME-1963640", "R-RNO-9652282", "R-HSA-1257604", "R-MMU-8863795", "R-MMU-2179392", "R-CEL-8863795", "R-RNO-6785631", "R-MMU-8856825", "R-HSA-74751", "R-HSA-1251932", "R-HSA-1250342", "R-HSA-1250347", "R-HSA-9665245", "R-CEL-1251985", "R-DME-6811558", "R-CEL-8847993", "R-HSA-8866910", "R-HSA-1236382", "R-MMU-2428928", "R-DME-9009391", "R-DME-8856828", "R-HSA-9938206", "R-DME-1250347", "R-MMU-1358803", "R-DME-8856825", "R-DME-180292", "R-HSA-9665246", "R-RNO-1963640", "R-CEL-445144", "R-DME-77387", "R-HSA-9927432", "R-HSA-1227986", "R-HSA-9665233", "R-CEL-416572", "R-CEL-180336", "R-MMU-2404192", "R-HSA-1236394", "R-RNO-2428928", "R-RNO-74751", "R-CEL-1963642", "R-RNO-1236394", "R-RNO-1250196", "R-DME-179812", "R-MMU-8857538", "R-MMU-177929"], "pathways": ["R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-74752:r:Signaling by Insulin receptor", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", 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"GO:0008924:L-malate dehydrogenase (quinone) activity:F"], "name": "MQO", "pathway_ids": ["PWY-7254", "PWY-5913"], "pathways": ["PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-5913:t:partial TCA cycle (obligate autotrophs)"], "type": "Family"}, "IPR006232": {"description": "Sucrose-6-phosphate hydrolase", "go_ids": ["GO:0004564", "GO:0005737", "GO:0005975"], "go_terms": ["GO:0004564:beta-fructofuranosidase activity:F", "GO:0005737:cytoplasm:C", "GO:0005975:carbohydrate metabolic process:P"], "name": "Suc6P_hydrolase", "pathway_ids": ["PWY-8314"], "pathways": ["PWY-8314:t:inulin degradation"], "type": "Family"}, "IPR006233": {"description": "Cystathionine beta-lyase, bacterial", "go_ids": ["GO:0006520", "GO:0047804"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0047804:cysteine-S-conjugate beta-lyase activity:F"], "name": "Cys_b_lyase_bac", "pathway_ids": ["PWY-1187", "PWY-601", "PWY-6936", "PWY-801", "PWY-7901", "PWY-6842", "PWY-2821", "PWY-8302"], "pathways": ["PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-801:t:homocysteine and cysteine interconversion", "PWY-7901:t:glucosinolate biosynthesis from tyrosine", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-2821:t:glucosinolate biosynthesis from phenylalanine", "PWY-8302:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine degradation"], "type": "Family"}, "IPR006234": {"description": "O-succinylhomoserine sulfhydrylase", "go_ids": [], "go_terms": [], "name": "O-succ-hSer_sulfhydrylase", "pathway_ids": ["PWY-4681", "PWY-8382", "PWY-8389", "PWY-7529", "PWY-8243", "PWY-7998", "PWY-6262", "PWY-8442", "PWY-5802", "PWY-7493", "PWY-5815", "PWY-5817", "PWY-8084", "PWY-7540", "PWY-7520", "PWY-7555", "PWY-8388", "PWY-6659", "PWY-7407", "PWY-7599", "PWY-7405", "PWY-7719", "PWY-6681", "PWY-8461", "PWY-7906", "PWY-7543", "PWY-8253", "PWY-7372", "PWY-8083", "PWY-5979", "PWY-5893", "PWY-7603", "PWY-6403", "PWY-7532", "PWY-6936", "PWY-7605", "PWY-5816", "PWY-7708", "PWY-7659", "PWY-4502", "PWY-7572", "PWY-8080"], "pathways": ["PWY-4681:t:kievitone biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-8389:t:penigequinolone biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-7998:t:menaquinol-4 biosynthesis II", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-8442:t:hyperxanthone E biosynthesis", "PWY-5802:t:alizarin biosynthesis", "PWY-7493:t:paxilline and diprenylpaxilline biosynthesis", "PWY-5815:t:rubber biosynthesis", "PWY-5817:t:dodecaprenyl diphosphate biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7540:t:aflatrem biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-8388:t:aspoquinolone biosynthesis", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-6681:t:neurosporaxanthin biosynthesis", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7906:t:rhizobitoxine biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-8083:t:domoic acid biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-5893:t:tridecaprenyl diphosphate biosynthesis", "PWY-7603:t:stephacidin A biosynthesis", "PWY-6403:t:carrageenan biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-7605:t:roquefortine C biosynthesis", "PWY-5816:t:all trans undecaprenyl diphosphate biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-4502:t:wighteone and luteone biosynthesis", "PWY-7572:t:lolitrem B biosynthesis", "PWY-8080:t:kainate biosynthesis"], "type": "Family"}, "IPR006235": {"description": "O-acetylhomoserine/O-acetylserine sulfhydrylase", "go_ids": ["GO:0006520", "GO:0016765"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "OAc-hSer/O-AcSer_sulfhydrylase", "pathway_ids": ["PWY-4681", "PWY-8382", "PWY-8389", "PWY-7529", "PWY-8243", "PWY-7998", "PWY-6262", "PWY-8442", "PWY-5802", "PWY-7493", "PWY-5815", "PWY-5817", "PWY-8084", "PWY-7540", "PWY-7520", "PWY-7555", "PWY-8388", "PWY-6659", "PWY-7407", "PWY-7599", "PWY-7405", "PWY-7719", "PWY-6681", "PWY-8461", "PWY-7906", "PWY-7543", "PWY-8253", "PWY-7372", "PWY-8083", "PWY-5979", "PWY-5893", "PWY-7603", "PWY-6403", "PWY-7532", "PWY-6936", "PWY-7605", "PWY-5816", "PWY-7708", "PWY-7659", "PWY-4502", "PWY-7572", "PWY-8080"], "pathways": ["PWY-4681:t:kievitone biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-8389:t:penigequinolone biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-7998:t:menaquinol-4 biosynthesis II", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-8442:t:hyperxanthone E biosynthesis", "PWY-5802:t:alizarin biosynthesis", "PWY-7493:t:paxilline and diprenylpaxilline biosynthesis", "PWY-5815:t:rubber biosynthesis", "PWY-5817:t:dodecaprenyl diphosphate biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7540:t:aflatrem biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-8388:t:aspoquinolone biosynthesis", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7405:t:aurachin RE 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biosynthesis", "PWY-7572:t:lolitrem B biosynthesis", "PWY-8080:t:kainate biosynthesis"], "type": "Family"}, "IPR006236": {"description": "D-3-phosphoglycerate dehydrogenase", "go_ids": ["GO:0004617", "GO:0006564"], "go_terms": ["GO:0004617:phosphoglycerate dehydrogenase activity:F", "GO:0006564:L-serine biosynthetic process:P"], "name": "PGDH", "pathway_ids": ["PWY-8010", "PWY-8190", "R-MMU-977347", "R-RNO-977347", "R-SSC-977347", "R-HSA-977347"], "pathways": ["PWY-8010:t:L-cysteine biosynthesis IX (Trichomonas vaginalis)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)", "R-MMU-977347:r:Serine metabolism", "R-RNO-977347:r:Serine metabolism", "R-SSC-977347:r:Serine metabolism", "R-HSA-977347:r:Serine metabolism"], "type": "Family"}, "IPR006237": {"description": "L-methionine gamma-lyase", "go_ids": ["GO:0018826"], "go_terms": ["GO:0018826:methionine gamma-lyase activity:F"], "name": "L-Met_gamma_lys", "pathway_ids": ["PWY-6931", "PWY-6933", "PWY-7793"], "pathways": ["PWY-6931:t:seleno-amino acid detoxification and volatilization I", "PWY-6933:t:seleno-amino acid detoxification and volatilization III", "PWY-7793:t:dimethyl sulfide biosynthesis from methionine"], "type": "Family"}, "IPR006238": {"description": "Cystathionine beta-lyase, eukaryotic", "go_ids": ["GO:0006790", "GO:0047804"], "go_terms": ["GO:0006790:sulfur compound metabolic process:P", "GO:0047804:cysteine-S-conjugate beta-lyase activity:F"], "name": "Cys_b_lyase_euk", "pathway_ids": ["PWY-1187", "PWY-601", "PWY-6936", "PWY-801", "PWY-7901", "PWY-6842", "PWY-2821", "PWY-8302"], "pathways": ["PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-801:t:homocysteine and cysteine interconversion", "PWY-7901:t:glucosinolate biosynthesis from tyrosine", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-2821:t:glucosinolate biosynthesis from phenylalanine", "PWY-8302:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine degradation"], "type": "Family"}, "IPR006239": {"description": "3(2),5 -bisphosphate nucleotidase", "go_ids": ["GO:0006790", "GO:0008441"], "go_terms": ["GO:0006790:sulfur compound metabolic process:P", "GO:0008441:3'(2'),5'-bisphosphate nucleotidase activity:F"], "name": "DPNP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006240": {"description": "3'(2'),5'-bisphosphate nucleotidase CysQ", "go_ids": ["GO:0008441", "GO:0006790", "GO:0000287"], "go_terms": ["GO:0008441:3'(2'),5'-bisphosphate nucleotidase activity:F", "GO:0006790:sulfur compound metabolic process:P", "GO:0000287:magnesium ion binding:F"], "name": "CysQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006241": {"description": "Photosystem II cytochrome b559, beta subunit", "go_ids": ["GO:0009539", "GO:0009767", "GO:0016020", "GO:0019684", "GO:0020037", "GO:0009523", "GO:0015979"], "go_terms": ["GO:0009539:photosystem II reaction center:C", "GO:0009767:photosynthetic electron transport chain:P", "GO:0016020:membrane:C", "GO:0019684:photosynthesis, light reaction:P", "GO:0020037:heme binding:F", "GO:0009523:photosystem II:C", "GO:0015979:photosynthesis:P"], "name": "PSII_cyt_b559_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006242": {"description": "Putative pyrophosphorylase ModD", "go_ids": ["GO:0016763"], "go_terms": ["GO:0016763:pentosyltransferase activity:F"], "name": "ModD", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis"], "type": "Family"}, "IPR006243": {"description": "Photosystem I PsaA", "go_ids": ["GO:0015979", "GO:0016020", "GO:0046872"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0016020:membrane:C", "GO:0046872:metal ion binding:F"], "name": "PSI_PsaA", "pathway_ids": ["PWY-101", "PWY-8270"], "pathways": ["PWY-101:t:photosynthesis light reactions", "PWY-8270:t:cyclic electron flow"], "type": "Family"}, "IPR006244": {"description": "Photosystem I PsaB", "go_ids": ["GO:0009522", "GO:0009579", "GO:0015979", "GO:0016020"], "go_terms": ["GO:0009522:photosystem I:C", "GO:0009579:thylakoid:C", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C"], "name": "PSI_PsaB", "pathway_ids": ["PWY-101", "PWY-8270"], "pathways": ["PWY-101:t:photosynthesis light reactions", "PWY-8270:t:cyclic electron flow"], "type": "Family"}, "IPR006245": {"description": "Allophycocyanin, beta subunit", "go_ids": ["GO:0015979", "GO:0030089"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0030089:phycobilisome:C"], "name": "Allophycocyanin_b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006246": {"description": "Phycocyanin, alpha subunit", "go_ids": ["GO:0015979", "GO:0030089"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0030089:phycobilisome:C"], "name": "Phycocyanin_a", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006247": {"description": "Phycocyanin, beta subunit", "go_ids": ["GO:0015979", "GO:0030089"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0030089:phycobilisome:C"], "name": "Phycocyanin_b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006248": {"description": "Aconitase, mitochondrial-like", "go_ids": ["GO:0003994", "GO:0006099", "GO:0051539"], "go_terms": ["GO:0003994:aconitate hydratase activity:F", "GO:0006099:tricarboxylic acid cycle:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Aconitase_mito-like", "pathway_ids": ["R-DDI-9837999", "R-HSA-9854311", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-9854311", "R-SPO-9854311", "R-BTA-71403", "R-RNO-9837999", "R-RNO-9854311", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-CEL-9854311", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-71403", "R-SCE-9837999", "R-HSA-1268020", "R-MMU-71403", "R-DDI-9854311", "R-DDI-71403", "R-HSA-9837999", "R-RNO-71403", "R-HSA-71403", "R-SCE-9854311"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Family"}, "IPR006249": {"description": "Aconitase/Iron-responsive element-binding protein 2", "go_ids": [], "go_terms": [], "name": "Aconitase/IRP2", "pathway_ids": ["R-MMU-917937", "R-CEL-917937", "R-CEL-389542", "R-HSA-917937", "R-DDI-917937", "R-RNO-917937", "R-HSA-389542", "R-SSC-917937", "R-MMU-389542", "R-RNO-389542", "R-DDI-389542"], "pathways": ["R-MMU-917937:r:Iron uptake and transport", "R-CEL-917937:r:Iron uptake and transport", "R-CEL-389542:r:NADPH regeneration", "R-HSA-917937:r:Iron uptake and transport", "R-DDI-917937:r:Iron uptake and transport", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-389542:r:NADPH regeneration", "R-SSC-917937:r:Iron uptake and transport", "R-MMU-389542:r:NADPH regeneration", "R-RNO-389542:r:NADPH regeneration", "R-DDI-389542:r:NADPH regeneration"], "type": "Family"}, "IPR006250": {"description": "Aconitase, putative", "go_ids": [], "go_terms": [], "name": "Aconitase_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006251": {"description": "Homoaconitase/3-isopropylmalate dehydratase, large subunit", "go_ids": ["GO:0008652", "GO:0016836", "GO:0051539"], "go_terms": ["GO:0008652:amino acid biosynthetic process:P", "GO:0016836:hydro-lyase activity:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Homoacnase/IPMdehydase_lsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006252": {"description": "Malate synthase A", "go_ids": [], "go_terms": [], "name": "Malate_synthA", "pathway_ids": ["PWY-7854", "PWY-7295", "PWY-7118", "PWY-7294"], "pathways": ["PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7295:t:L-arabinose degradation IV", "PWY-7118:t:chitin deacetylation", "PWY-7294:t:D-xylose degradation IV"], "type": "Family"}, "IPR006253": {"description": "Malate synthase G", "go_ids": ["GO:0004474", "GO:0006097"], "go_terms": ["GO:0004474:malate synthase activity:F", "GO:0006097:glyoxylate cycle:P"], "name": "Malate_synthG", "pathway_ids": ["PWY-7854", "PWY-7295", "PWY-7118", "PWY-7294"], "pathways": ["PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7295:t:L-arabinose degradation IV", "PWY-7118:t:chitin deacetylation", "PWY-7294:t:D-xylose degradation IV"], "type": "Family"}, "IPR006254": {"description": "Isocitrate lyase", "go_ids": ["GO:0004451", "GO:0019752"], "go_terms": ["GO:0004451:isocitrate lyase activity:F", "GO:0019752:carboxylic acid metabolic process:P"], "name": "Isocitrate_lyase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006255": {"description": "Dihydrolipoamide succinyltransferase", "go_ids": ["GO:0004149", "GO:0006099", "GO:0045252"], "go_terms": ["GO:0004149:dihydrolipoyllysine-residue succinyltransferase activity:F", "GO:0006099:tricarboxylic acid cycle:P", "GO:0045252:oxoglutarate dehydrogenase complex:C"], "name": "SucB", "pathway_ids": ["PWY-5084", "R-MMU-6783984", "R-SCE-9853506", "R-MMU-9857492", "R-SPO-9853506", "R-HSA-9853506", "R-SCE-6783984", "R-RNO-9857492", "R-SCE-9857492", "R-DDI-9857492", "R-RNO-9853506", "R-RNO-9858328", "R-HSA-9857492", "R-DDI-9858328", "R-SPO-9857492", "R-RNO-6783984", "R-DDI-9853506", "R-HSA-9858328", "R-HSA-6783984", "R-DDI-6783984", "R-SPO-6783984", "R-MMU-9858328", "R-MMU-9853506"], "pathways": ["PWY-5084:t:2-oxoglutarate decarboxylation to succinyl-CoA", "R-MMU-6783984:r:Glycine degradation", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-9857492:r:Protein lipoylation", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SCE-6783984:r:Glycine degradation", "R-RNO-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-DDI-9857492:r:Protein lipoylation", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-RNO-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9857492:r:Protein lipoylation", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SPO-9857492:r:Protein lipoylation", "R-RNO-6783984:r:Glycine degradation", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-6783984:r:Glycine degradation", "R-DDI-6783984:r:Glycine degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG"], "type": "Family"}, "IPR006256": {"description": "Dihydrolipoamide acetyltransferase pyruvate dehydrogenase complex", "go_ids": ["GO:0004742", "GO:0045254"], "go_terms": ["GO:0004742:dihydrolipoyllysine-residue acetyltransferase activity:F", "GO:0045254:pyruvate dehydrogenase complex:C"], "name": "AcTrfase_Pyrv_DH_cplx", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006257": {"description": "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex", "go_ids": ["GO:0004742", "GO:0006090", "GO:0045254"], "go_terms": ["GO:0004742:dihydrolipoyllysine-residue acetyltransferase activity:F", "GO:0006090:pyruvate metabolic process:P", 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secretion protein HrpO", "go_ids": ["GO:0016020", "GO:0009306"], "go_terms": ["GO:0016020:membrane:C", "GO:0009306:protein secretion:P"], "name": "T3SS_HrpO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006307": {"description": "Type III exporter system, secretion apparatus protein BsaZ-like", "go_ids": ["GO:0016020", "GO:0009306"], "go_terms": ["GO:0016020:membrane:C", "GO:0009306:protein secretion:P"], "name": "BsaZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006308": {"description": "DNA polymerase III, alpha subunit, PolC-type, Gram-positive bacteria", "go_ids": ["GO:0003677", "GO:0003887", "GO:0005737", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0005737:cytoplasm:C", "GO:0006260:DNA replication:P"], "name": "Pol_III_a_PolC-type_gram_pos", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006309": {"description": "DNA polymerase 3, epsilon subunit", "go_ids": ["GO:0003677", "GO:0003887", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P"], "name": "DnaQ_proteo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006310": {"description": "3'-5' exonuclease DinG", "go_ids": ["GO:0008408", "GO:0005524"], "go_terms": ["GO:0008408:3'-5' exonuclease activity:F", "GO:0005524:ATP binding:F"], "name": "DinG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006312": {"description": "Sec-independent protein translocase protein TatA/E", "go_ids": ["GO:0016020", "GO:0043953"], "go_terms": ["GO:0016020:membrane:C", "GO:0043953:protein transport by the Tat complex:P"], "name": "TatA/E", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006313": {"description": "Deferrochelatase", "go_ids": ["GO:0004601", "GO:0020037", "GO:0033212"], "go_terms": ["GO:0004601:peroxidase activity:F", "GO:0020037:heme binding:F", "GO:0033212:iron import into 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"R-DME-9865881"], "pathways": ["PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "PWY-6692:t:Fe(II) oxidation", "PWY-3781:t:aerobic respiration I (cytochrome c)", "R-HSA-9865881:r:Complex III assembly", "R-DRE-9865881:r:Complex III assembly", "R-GGA-9865881:r:Complex III assembly", "R-SCE-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SPO-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-9865881:r:Complex III assembly", "R-BTA-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-SSC-9865881:r:Complex III assembly", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR006318": {"description": "Phosphotransferase system, enzyme I-like", "go_ids": ["GO:0016772"], "go_terms": ["GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "PTS_EI-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006319": {"description": "Phosphoenolpyruvate synthase", "go_ids": ["GO:0008986", "GO:0006090"], "go_terms": ["GO:0008986:pyruvate, water dikinase activity:F", "GO:0006090:pyruvate metabolic process:P"], "name": "PEP_synth", "pathway_ids": ["PWY-5484", "PWY-6142"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)"], "type": "Family"}, "IPR006320": {"description": "Phosphotransferase system, IIA-like nitrogen-regulatory protein PtsN", "go_ids": ["GO:0008982", "GO:0009401"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", 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"R-SPO-499943", "R-MMU-499943", "R-RNO-3299685", "R-DDI-3299685", "R-SCE-3299685", "R-SPO-3299685", "R-CEL-499943", "R-MMU-5628897", "R-DDI-499943", "R-RNO-499943", "R-HSA-9818027"], "pathways": ["PWY-4081:t:glutathione-peroxide redox reactions", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-499943:r:Interconversion of nucleotide di- and 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"R-RNO-9755088:r:Ribavirin ADME", "R-RNO-74217:r:Purine salvage", "R-DME-2161541:r:Abacavir metabolism", "R-DRE-2161541:r:Abacavir metabolism", "R-HSA-2161541:r:Abacavir metabolism", "R-PFA-9755088:r:Ribavirin ADME", "R-XTR-9755088:r:Ribavirin ADME", "R-XTR-74217:r:Purine salvage", "R-CEL-74217:r:Purine salvage", "R-MMU-9755088:r:Ribavirin ADME", "R-CEL-2161541:r:Abacavir metabolism", "R-DME-74217:r:Purine salvage", "R-HSA-9734735:r:Defective ADA disrupts (deoxy)adenosine deamination", "R-DDI-74217:r:Purine salvage", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-5683826:r:Surfactant metabolism", "R-MMU-74217:r:Purine salvage", "R-DRE-9755088:r:Ribavirin ADME", "R-HSA-74217:r:Purine salvage", "R-PFA-74217:r:Purine salvage", "R-HSA-9755088:r:Ribavirin ADME"], "type": "Family"}, "IPR006331": {"description": "Adenosine deaminase-related growth factor", "go_ids": ["GO:0004000", "GO:0006154", "GO:0005576"], "go_terms": ["GO:0004000:adenosine deaminase activity:F", "GO:0006154:adenosine 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"QoxA", "pathway_ids": ["PWY-5787", "PWY-5780", "PWY-5399", "PWY-7079", "PWY-5476", "PWY-5439", "PWY-5404"], "pathways": ["PWY-5787:t:oligomeric urushiol biosynthesis", "PWY-5780:t:hypericin biosynthesis", "PWY-5399:t:betacyanin biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-5476:t:cornusiin E biosynthesis", "PWY-5439:t:betacyanin biosynthesis (via dopamine)", "PWY-5404:t:betaxanthin biosynthesis (via dopaxanthin)"], "type": "Family"}, "IPR006333": {"description": "Cytochrome o ubiquinol oxidase subunit II", "go_ids": ["GO:0016020", "GO:0016682"], "go_terms": ["GO:0016020:membrane:C", "GO:0016682:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor:F"], "name": "Cyt_o_ubiquinol_oxidase_su2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006334": {"description": "Glutamate--cysteine ligase, monofunctional", "go_ids": ["GO:0004357", "GO:0006750"], "go_terms": ["GO:0004357:glutamate-cysteine ligase activity:F", "GO:0006750:glutathione biosynthetic process:P"], "name": "Glut_cys_ligase", "pathway_ids": ["PWY-8043", "PWY-6840", "PWY-7255"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "PWY-6840:t:homoglutathione biosynthesis", "PWY-7255:t:ergothioneine biosynthesis I (bacteria)"], "type": "Family"}, "IPR006335": {"description": "Glutathione biosynthesis bifunctional protein GshAB", "go_ids": ["GO:0004357", "GO:0006750"], "go_terms": ["GO:0004357:glutamate-cysteine ligase activity:F", "GO:0006750:glutathione biosynthetic process:P"], "name": "Glut_biosynth", "pathway_ids": ["PWY-8043", "PWY-6840", "PWY-7255"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "PWY-6840:t:homoglutathione biosynthesis", "PWY-7255:t:ergothioneine biosynthesis I (bacteria)"], "type": "Family"}, "IPR006336": {"description": "Glutamate--cysteine ligase, GCS2", "go_ids": ["GO:0004357", "GO:0042398"], "go_terms": ["GO:0004357:glutamate-cysteine ligase activity:F", "GO:0042398:modified amino acid biosynthetic process:P"], "name": "GCS2", "pathway_ids": ["PWY-8043", "PWY-6840", "PWY-7255"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "PWY-6840:t:homoglutathione biosynthesis", "PWY-7255:t:ergothioneine biosynthesis I (bacteria)"], "type": "Family"}, "IPR006337": {"description": "D-glucosaminate-6-phosphate ammonia lyase DgaE-like", "go_ids": [], "go_terms": [], "name": "DgaE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006338": {"description": "Thioredoxin/glutathione reductase selenoprotein", "go_ids": ["GO:0004791"], "go_terms": ["GO:0004791:thioredoxin-disulfide reductase (NADPH) activity:F"], "name": "Thioredoxin/glutathione_Rdtase", "pathway_ids": ["R-HSA-1989781", "R-HSA-3299685", "R-BTA-5263617", "R-MMU-5263617", "R-PFA-5263617", "R-CEL-5263617", "R-RNO-5628897", "R-CEL-5628897", "R-HSA-5263617", "R-HSA-2408550", "R-CEL-3299685", "R-MMU-3299685", "R-HSA-499943", "R-RNO-3299685", "R-HSA-5628897", "R-BTA-5628897", "R-MMU-499943", "R-DME-499943", "R-BTA-3299685", "R-DME-5263617", "R-HSA-5336415", "R-RNO-5263617", "R-BTA-499943", "R-CEL-499943", "R-MMU-5628897", "R-DME-3299685", "R-DME-5628897", "R-RNO-499943", "R-HSA-9818027"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-MMU-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-PFA-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-CEL-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-RNO-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes"], "type": "Family"}, "IPR006340": {"description": "Protein of unknown function DUF436", "go_ids": [], "go_terms": [], "name": "DUF436", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006341": {"description": "Acid-soluble spore protein, gamma-type", "go_ids": ["GO:0030435"], "go_terms": ["GO:0030435:sporulation resulting in formation of a cellular spore:P"], "name": "Spore_gamma", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006342": {"description": "Methyltransferase FkbM", "go_ids": [], "go_terms": [], "name": "FkbM_mtfrase", "pathway_ids": ["PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380"], "pathways": ["PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis"], "type": "Domain"}, "IPR006343": {"description": "DnaB/C, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DnaB/C_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006344": {"description": "RecBCD enzyme subunit RecD", "go_ids": ["GO:0008854", "GO:0009338", "GO:0006302", "GO:0006310", "GO:0004386"], "go_terms": ["GO:0008854:exodeoxyribonuclease V activity:F", "GO:0009338:exodeoxyribonuclease V complex:C", "GO:0006302:double-strand break repair:P", "GO:0006310:DNA recombination:P", "GO:0004386:helicase activity:F"], "name": "RecD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006345": {"description": "ATP-dependent RecD2 DNA helicase", "go_ids": ["GO:0006310", "GO:0043139", "GO:0003677"], "go_terms": ["GO:0006310:DNA recombination:P", "GO:0043139:5'-3' DNA helicase activity:F", "GO:0003677:DNA binding:F"], "name": "RecD2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006349": {"description": "2-phosphoglycolate phosphatase, eukaryotic", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "PGP_euk", "pathway_ids": ["PWY-8362", "PWY-8363", "PWY-181", "R-CEL-9013407", "R-MMU-1483206", "R-HSA-1483206", "R-RNO-1483206", "R-BTA-1483206"], "pathways": ["PWY-8362:t:photorespiration II", "PWY-8363:t:photorespiration III", "PWY-181:t:photorespiration I", "R-CEL-9013407:r:RHOH GTPase cycle", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-RNO-1483206:r:Glycerophospholipid biosynthesis", "R-BTA-1483206:r:Glycerophospholipid biosynthesis"], "type": "Family"}, "IPR006350": {"description": "Intron endonuclease, group I", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "Intron_endoG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006351": {"description": "3-amino-5-hydroxybenzoic acid synthesis-related", "go_ids": [], "go_terms": [], "name": "AHBA_synth-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006352": {"description": "Phosphoglucosamine mutase, bacterial type", "go_ids": ["GO:0000287", "GO:0005975", "GO:0008966"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0008966:phosphoglucosamine mutase activity:F"], "name": "GlmM_bact", "pathway_ids": ["PWY-6749"], "pathways": ["PWY-6749:t:CMP-legionaminate biosynthesis I"], "type": "Family"}, "IPR006353": {"description": "HAD-superfamily hydrolase, subfamily IIA, CECR5", "go_ids": [], "go_terms": [], "name": "HAD-SF_hydro_IIA_CECR5", "pathway_ids": ["R-SPO-1482925", "R-SPO-1483076"], "pathways": ["R-SPO-1482925:r:Acyl chain remodelling of PG", "R-SPO-1483076:r:Synthesis of CL"], "type": "Family"}, "IPR006354": {"description": "HAD-superfamily hydrolase, subfamily IIA, hypothetical 1", "go_ids": [], "go_terms": [], "name": "HAD-SF_hydro_IIA_hyp1", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR006355": {"description": "HAD hydrolase, LHPP/HDHD2", "go_ids": ["GO:0016791", "GO:0016311"], "go_terms": ["GO:0016791:phosphatase activity:F", "GO:0016311:dephosphorylation:P"], "name": "LHPP/HDHD2", "pathway_ids": ["R-RNO-71737", "R-DRE-71737", "R-BTA-71737", "R-MMU-71737", "R-HSA-71737"], "pathways": ["R-RNO-71737:r:Pyrophosphate hydrolysis", "R-DRE-71737:r:Pyrophosphate hydrolysis", "R-BTA-71737:r:Pyrophosphate hydrolysis", "R-MMU-71737:r:Pyrophosphate hydrolysis", "R-HSA-71737:r:Pyrophosphate hydrolysis"], "type": "Family"}, "IPR006356": {"description": "HAD-superfamily hydrolase, subfamily IIA, hypothetical 3", 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subunit", "go_ids": ["GO:0050097"], "go_terms": ["GO:0050097:methylaspartate mutase activity:F"], "name": "Glu_mut_E", "pathway_ids": ["PWY-6728", "PWY-5087", "PWY-5103"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5087:t:L-glutamate degradation VI (to pyruvate)", "PWY-5103:t:L-isoleucine biosynthesis III"], "type": "Family"}, "IPR006397": {"description": "Glyoxylate carboligase", "go_ids": ["GO:0009028", "GO:0009436"], "go_terms": ["GO:0009028:tartronate-semialdehyde synthase activity:F", "GO:0009436:glyoxylate catabolic process:P"], "name": "Glyox_carbo_lig", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006398": {"description": "2-hydroxy-3-oxopropionate reductase", "go_ids": ["GO:0008679", "GO:0046487"], "go_terms": ["GO:0008679:2-hydroxy-3-oxopropionate reductase activity:F", "GO:0046487:glyoxylate metabolic process:P"], "name": "Tartro_sem_red", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006399": {"description": "Riboflavin synthase, 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"Nicotinate phosphoribosyltransferase pncB-type", "go_ids": ["GO:0004516", "GO:0009435"], "go_terms": ["GO:0004516:nicotinate phosphoribosyltransferase activity:F", "GO:0009435:NAD+ biosynthetic process:P"], "name": "Nic_PRibTrfase_pncB", "pathway_ids": ["PWY-5381", "R-MMU-196807", "R-DDI-6798695", "R-HSA-6798695", "R-DRE-6798695", "R-DME-196807", "R-DME-6798695", "R-DRE-196807", "R-CEL-6798695", "R-CEL-196807", "R-HSA-196807", "R-MMU-6798695", "R-DDI-196807", "R-RNO-6798695", "R-RNO-196807"], "pathways": ["PWY-5381:t:NAD salvage (plants)", "R-MMU-196807:r:Nicotinate metabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-196807:r:Nicotinate metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-DRE-196807:r:Nicotinate metabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-196807:r:Nicotinate metabolism"], "type": "Family"}, "IPR006406": {"description": "Nicotinate phosphoribosyltransferase", "go_ids": ["GO:0004516", "GO:0009435"], "go_terms": ["GO:0004516:nicotinate phosphoribosyltransferase activity:F", "GO:0009435:NAD+ biosynthetic process:P"], "name": "Nic_PRibTrfase", "pathway_ids": ["PWY-5381"], "pathways": ["PWY-5381:t:NAD salvage (plants)"], "type": "Family"}, "IPR006407": {"description": "1,4-alpha-glucan-branching enzyme, GlgB", "go_ids": ["GO:0003844", "GO:0005978"], "go_terms": ["GO:0003844:1,4-alpha-glucan branching enzyme activity:F", "GO:0005978:glycogen biosynthetic process:P"], "name": "GlgB", "pathway_ids": ["PWY-622", "PWY-7900", "PWY-5067"], "pathways": ["PWY-622:t:starch biosynthesis", "PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)", "PWY-5067:t:glycogen biosynthesis II (from UDP-D-Glucose)"], "type": "Family"}, "IPR006408": {"description": "P-type ATPase, subfamily IIB", "go_ids": ["GO:0005524", "GO:0016020", "GO:0070588", "GO:0005388"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016020:membrane:C", "GO:0070588:calcium ion transmembrane transport:P", "GO:0005388:P-type calcium transporter activity:F"], "name": "P-type_ATPase_IIB", "pathway_ids": ["R-DDI-936837", "R-CEL-418359", "R-GGA-936837", "R-GGA-418359", "R-SCE-418359", "R-GGA-5578775", "R-RNO-5578775", "R-HSA-9662361", "R-RNO-418359", "R-SPO-418359", "R-MMU-5578775", "R-DDI-5578775", "R-HSA-936837", "R-SPO-936837", "R-BTA-936837", "R-RNO-936837", "R-SCE-5578775", "R-SCE-936837", "R-MMU-418359", "R-CEL-5578775", "R-HSA-9662360", "R-BTA-5578775", "R-HSA-5578775", "R-MMU-936837", "R-SPO-5578775", "R-DDI-418359", "R-CEL-936837", "R-BTA-418359", "R-HSA-418359"], "pathways": ["R-DDI-936837:r:Ion transport by P-type ATPases", "R-CEL-418359:r:Reduction of cytosolic Ca++ levels", "R-GGA-936837:r:Ion transport by P-type ATPases", "R-GGA-418359:r:Reduction of cytosolic Ca++ levels", "R-SCE-418359:r:Reduction of cytosolic Ca++ levels", "R-GGA-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-5578775:r:Ion homeostasis", "R-DDI-5578775:r:Ion homeostasis", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-SPO-936837:r:Ion transport by P-type ATPases", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-5578775:r:Ion homeostasis", "R-SCE-936837:r:Ion transport by P-type ATPases", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-CEL-5578775:r:Ion homeostasis", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-SPO-5578775:r:Ion homeostasis", "R-DDI-418359:r:Reduction of cytosolic Ca++ levels", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-BTA-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Family"}, "IPR006409": {"description": "Glycerol-3-phosphate cytidylyltransferase", "go_ids": ["GO:0005737", "GO:0019350", "GO:0046872", "GO:0047348"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0019350:teichoic acid biosynthetic process:P", "GO:0046872:metal ion binding:F", "GO:0047348:glycerol-3-phosphate cytidylyltransferase activity:F"], "name": "G3P_cytidylTrfase", "pathway_ids": ["PWY-7819", "PWY-8430", "PWY-8248", "PWY-8429", "PWY-7816", "PWY-7815"], "pathways": ["PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"], "type": "Family"}, "IPR006410": {"description": "Conserved hypothetical protein CHP01519, plasmodium", "go_ids": [], "go_terms": [], "name": "CHP01519_PLAF7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006411": {"description": "Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype", "go_ids": ["GO:0004332", "GO:0006096"], "go_terms": ["GO:0004332:fructose-bisphosphate aldolase activity:F", "GO:0006096:glycolytic process:P"], "name": "Fruct_bisP_bact", "pathway_ids": ["PWY-1042", "PWY-8178", "PWY-8404", "PWY-6142", "PWY-1861", "PWY-7385", "PWY-5484"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)"], "type": "Family"}, "IPR006412": {"description": "Fructose-bisphosphate aldolase, class II, Calvin cycle subtype", "go_ids": ["GO:0004332", "GO:0006096"], "go_terms": ["GO:0004332:fructose-bisphosphate aldolase activity:F", "GO:0006096:glycolytic process:P"], "name": "Fruct_bisP_Calv", "pathway_ids": ["PWY-1042", "PWY-8178", "PWY-8404", "PWY-6142", "PWY-1861", "PWY-7385", "PWY-5484"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)"], "type": "Family"}, "IPR006413": {"description": "P-type ATPase, subfamily IIA, PMR1-type", "go_ids": ["GO:0005388", "GO:0006816", "GO:0016020"], "go_terms": ["GO:0005388:P-type calcium transporter activity:F", "GO:0006816:calcium ion transport:P", "GO:0016020:membrane:C"], "name": "P-type_ATPase_IIA_PMR1", "pathway_ids": ["R-SPO-936837", "R-HSA-936837", "R-MMU-936837", "R-BTA-936837", "R-RNO-936837", "R-SCE-936837"], "pathways": ["R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases"], "type": "Family"}, "IPR006414": {"description": "P-type ATPase, subfamily IID", "go_ids": ["GO:0006812", "GO:0016020", "GO:0019829"], "go_terms": ["GO:0006812:monoatomic cation transport:P", "GO:0016020:membrane:C", "GO:0019829:ATPase-coupled monoatomic cation transmembrane transporter activity:F"], "name": "P-type_ATPase_IID", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006415": {"description": "P-type ATPase, subfamily IIIB", "go_ids": ["GO:0015444", "GO:0015693", "GO:0016020"], "go_terms": ["GO:0015444:P-type magnesium transporter activity:F", "GO:0015693:magnesium ion transport:P", "GO:0016020:membrane:C"], "name": "P-type_ATPase_IIIB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006417": {"description": "Nicotinamide-nucleotide adenylyltransferase", "go_ids": ["GO:0000309", "GO:0009435"], "go_terms": ["GO:0000309:nicotinamide-nucleotide adenylyltransferase activity:F", "GO:0009435:NAD+ biosynthetic process:P"], "name": "NadR_NMN_Atrans", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006418": {"description": "Nicotinamide-nucleotide adenylyltransferase, archaea", "go_ids": ["GO:0000309", "GO:0005737", "GO:0009435"], "go_terms": ["GO:0000309:nicotinamide-nucleotide adenylyltransferase activity:F", "GO:0005737:cytoplasm:C", "GO:0009435:NAD+ biosynthetic process:P"], "name": "NMN_Atrans_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006419": {"description": "Nicotinamide mononucleotide transporter PnuC", "go_ids": ["GO:0016020", "GO:0034258", "GO:0034257"], "go_terms": ["GO:0016020:membrane:C", "GO:0034258:nicotinamide riboside transport:P", "GO:0034257:nicotinamide riboside transmembrane transporter activity:F"], "name": "NMN_transpt_PnuC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006420": {"description": "NAD pyrophosphatase/5-nucleotidase NadN", "go_ids": ["GO:0008253", "GO:0009166"], "go_terms": ["GO:0008253:5'-nucleotidase activity:F", "GO:0009166:nucleotide catabolic process:P"], "name": "NadN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006421": {"description": "Glycogen debranching enzyme, metazoa", "go_ids": ["GO:0004134", "GO:0004135", "GO:0005978"], "go_terms": ["GO:0004134:4-alpha-glucanotransferase activity:F", "GO:0004135:amylo-alpha-1,6-glucosidase activity:F", "GO:0005978:glycogen biosynthetic process:P"], "name": "Glycogen_debranch_met", "pathway_ids": ["PWY-7238", "PWY-6724", "PWY-5941", "PWY-6737", "R-SCE-70221", "R-HSA-6798695", "R-HSA-70221", "R-SCE-6798695"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6724:t:starch degradation II", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-SCE-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR006422": {"description": "D-erythrose-4-phosphate dehydrogenase", "go_ids": ["GO:0005737", "GO:0042823", "GO:0048001", "GO:0051287"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0042823:pyridoxal 5'-phosphate biosynthetic process:P", "GO:0048001:erythrose-4-phosphate dehydrogenase activity:F", "GO:0051287:NAD binding:F"], "name": "E4P_DH_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006423": {"description": "5-nucleotidase lipoprotein e(P4)", "go_ids": ["GO:0009279"], "go_terms": ["GO:0009279:cell outer membrane:C"], "name": "Lipo_e_P4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006424": {"description": "Glyceraldehyde-3-phosphate dehydrogenase, type I", "go_ids": ["GO:0016620", "GO:0050661", "GO:0051287", "GO:0006006"], "go_terms": ["GO:0016620:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor:F", "GO:0050661:NADP binding:F", "GO:0051287:NAD binding:F", "GO:0006006:glucose metabolic process:P"], "name": "Glyceraldehyde-3-P_DH_1", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-MMU-70171", "R-DRE-70263", "R-RNO-70263", "R-SCE-70171", "R-HSA-390471", "R-BTA-70171", "R-DME-70171", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-GGA-70171", "R-DME-70263", "R-DDI-70263", "R-GGA-70263", "R-RNO-70171", "R-GGA-352882", "R-CEL-70263", "R-HSA-70263", "R-BTA-70263", "R-SCE-70263", "R-DRE-70171", "R-HSA-70171", "R-SPO-70171", "R-SPO-70263"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-DRE-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-GGA-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-GGA-70263:r:Gluconeogenesis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-CEL-70263:r:Gluconeogenesis", "R-HSA-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-DRE-70171:r:Glycolysis", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Family"}, "IPR006425": {"description": "Glucoamylase, bacterial", "go_ids": [], "go_terms": [], "name": "Glucoamylase_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006426": {"description": "Asparagine synthase, glutamine-hydrolyzing", "go_ids": ["GO:0004066", "GO:0070981"], "go_terms": ["GO:0004066:asparagine synthase (glutamine-hydrolyzing) activity:F", "GO:0070981:L-asparagine biosynthetic process:P"], "name": "Asn_synth_AEB", "pathway_ids": ["R-HSA-9648895", "R-HSA-380994", "R-SPO-8963693", "R-HSA-9633012", "R-GGA-8963693", "R-RNO-8963693", "R-HSA-8963693", "R-DDI-8963693", "R-MMU-8963693", "R-BTA-8963693", "R-SCE-8963693"], "pathways": ["R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-SPO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-GGA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-DDI-8963693:r:Aspartate and asparagine metabolism", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-BTA-8963693:r:Aspartate and asparagine metabolism", "R-SCE-8963693:r:Aspartate and asparagine metabolism"], "type": "Family"}, "IPR006427": {"description": "Phage portal protein, HK97", "go_ids": [], "go_terms": [], "name": "Portal_HK97", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006428": {"description": "Portal protein, SPP1-type", "go_ids": [], "go_terms": [], "name": "Portal_SPP1-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006429": {"description": "Phage portal protein, lambda family", "go_ids": ["GO:0005198", "GO:0019068"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019068:virion assembly:P"], "name": "Phage_lambda_portal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006430": {"description": "Phage portal protein PBSX family", "go_ids": [], "go_terms": [], "name": "Phage_portal_PBSX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006431": {"description": "Bacteriophage tail tape measure, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_tape_meas_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006432": {"description": "Phage portal protein, A118-type", "go_ids": [], "go_terms": [], "name": "Phage_portal_A118-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006433": {"description": "Prohead protease", "go_ids": [], "go_terms": [], "name": "Prohead_protease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006434": {"description": "Pyrimidine 5'-nucleotidase, eukaryotic", "go_ids": ["GO:0000287", "GO:0005737", "GO:0008253"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0005737:cytoplasm:C", "GO:0008253:5'-nucleotidase activity:F"], "name": "Pyrimidine_nucleotidase_eu", "pathway_ids": ["PWY-7821", "PWY-7185", "PWY-5381", "PWY-6596", "PWY-5695", "PWY-6607", "PWY-6608", "PWY-6606", "R-RNO-429958", "R-DME-429958", "R-CEL-429958", "R-DME-73621", "R-GGA-73621", "R-MMU-429958", "R-HSA-429958", "R-HSA-73621", "R-DRE-73621", "R-MMU-73621", "R-CEL-73621"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-5381:t:NAD salvage (plants)", "PWY-6596:t:adenosine nucleotides degradation I", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-73621:r:Pyrimidine catabolism", "R-GGA-73621:r:Pyrimidine catabolism", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-73621:r:Pyrimidine catabolism", "R-DRE-73621:r:Pyrimidine catabolism", "R-MMU-73621:r:Pyrimidine catabolism", "R-CEL-73621:r:Pyrimidine catabolism"], "type": "Family"}, "IPR006435": {"description": "Phosphatidylglycerophosphatase C", "go_ids": [], "go_terms": [], "name": "PgpC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006436": {"description": "Glyceraldehyde-3-phosphate dehydrogenase, type II", "go_ids": ["GO:0016620", "GO:0005737", "GO:0006096", "GO:0050661", "GO:0051287"], "go_terms": ["GO:0016620:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor:F", "GO:0005737:cytoplasm:C", "GO:0006096:glycolytic process:P", "GO:0050661:NADP binding:F", "GO:0051287:NAD binding:F"], "name": "Glyceraldehyde-3-P_DH_2_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006437": {"description": "Bacteriophage terminase, large subunit", "go_ids": [], "go_terms": [], "name": "Phage_terminase_lsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006438": {"description": "HAD hydrolase, TIGR01548 family", "go_ids": [], "go_terms": [], "name": "HAD-SF_TIGR01548", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006439": {"description": "HAD hydrolase, subfamily IA", "go_ids": [], "go_terms": [], "name": "HAD-SF_hydro_IA", "pathway_ids": ["R-SSC-9033241", "R-HSA-73614", "R-SPO-73614", "R-MMU-2142670", "R-XTR-1237112", "R-MMU-9033241", "R-MMU-73614", "R-DME-73614", "R-RNO-9018682", "R-HSA-1237112", "R-DRE-1237112", "R-DRE-71737", "R-RNO-9033241", "R-BTA-1237112", "R-SPO-1237112", "R-RNO-1237112", "R-DME-1237112", "R-MMU-4085001", "R-RNO-4085001", "R-SSC-9018682", "R-RNO-2142670", "R-MMU-77289", "R-MMU-1237112", "R-HSA-4085001", "R-SCE-73614", "R-HSA-9033241", "R-MMU-9018682", "R-HSA-9018682", "R-CEL-1237112", "R-HSA-77289", "R-SSC-2142670", "R-HSA-2142670"], "pathways": ["R-SSC-9033241:r:Peroxisomal protein import", "R-HSA-73614:r:Pyrimidine salvage", "R-SPO-73614:r:Pyrimidine salvage", "R-MMU-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-XTR-1237112:r:Methionine salvage pathway", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-73614:r:Pyrimidine salvage", "R-DME-73614:r:Pyrimidine salvage", "R-RNO-9018682:r:Biosynthesis of maresins", "R-HSA-1237112:r:Methionine salvage pathway", "R-DRE-1237112:r:Methionine salvage pathway", "R-DRE-71737:r:Pyrophosphate hydrolysis", "R-RNO-9033241:r:Peroxisomal protein import", "R-BTA-1237112:r:Methionine salvage pathway", "R-SPO-1237112:r:Methionine salvage pathway", "R-RNO-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-MMU-4085001:r:Sialic acid metabolism", "R-RNO-4085001:r:Sialic acid metabolism", "R-SSC-9018682:r:Biosynthesis of maresins", "R-RNO-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-1237112:r:Methionine salvage pathway", "R-HSA-4085001:r:Sialic acid metabolism", "R-SCE-73614:r:Pyrimidine salvage", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-9018682:r:Biosynthesis of maresins", "R-HSA-9018682:r:Biosynthesis of maresins", "R-CEL-1237112:r:Methionine salvage pathway", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SSC-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-HSA-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "type": "Family"}, "IPR006440": {"description": "Death on curing protein", "go_ids": ["GO:0016301"], "go_terms": ["GO:0016301:kinase activity:F"], "name": "Doc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006441": {"description": "Bacteriophage P2, capsid", "go_ids": [], "go_terms": [], "name": "Phage_P2_GpN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006442": {"description": "Type II toxin-antitoxin system, antitoxin Phd/YefM", "go_ids": [], "go_terms": [], "name": "Antitoxin_Phd/YefM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006443": {"description": "Formate dehydrogenase-N, alpha subunit", "go_ids": ["GO:0008863", "GO:0043546", "GO:0009055", "GO:0045333", "GO:0047111"], "go_terms": ["GO:0008863:formate dehydrogenase (NAD+) activity:F", "GO:0043546:molybdopterin cofactor binding:F", "GO:0009055:electron transfer activity:F", "GO:0045333:cellular respiration:P", "GO:0047111:formate dehydrogenase (cytochrome-c-553) activity:F"], "name": "Formate-DH-alph_fdnG", "pathway_ids": ["PWY-6696", "PWY-7985", "PWY-1881", "PWY-5497"], "pathways": ["PWY-6696:t:oxalate degradation III", "PWY-7985:t:oxalate degradation VI", "PWY-1881:t:formate oxidation to CO2", "PWY-5497:t:purine nucleobases degradation II (anaerobic)"], "type": "Family"}, "IPR006445": {"description": "Phage-associated protein HI1409", "go_ids": [], "go_terms": [], "name": "Phage-assoc_HI1409", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006446": {"description": "Rhamnosyltransferase", "go_ids": [], "go_terms": [], "name": "RhaTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006447": {"description": "Myb domain, plants", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Myb_dom_plants", "pathway_ids": ["R-DDI-5689901"], "pathways": ["R-DDI-5689901:r:Metalloprotease DUBs"], "type": "Domain"}, "IPR006448": {"description": "Putative phage terminase, small subunit, P27 family", "go_ids": [], "go_terms": [], "name": "Phage_term_ssu_P27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006449": {"description": "Squalene synthase-like", "go_ids": ["GO:0008610", "GO:0051996"], "go_terms": ["GO:0008610:lipid biosynthetic process:P", "GO:0051996:squalene synthase [NAD(P)H] activity:F"], "name": "Squal_synth-like", "pathway_ids": ["R-SCE-9969896", "R-HSA-1989781", "R-DDI-9969896", "R-MMU-9969896", "R-RNO-9969896", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR006450": {"description": "Phage HK97 gp6-like", "go_ids": [], "go_terms": [], "name": "Phage_HK97_gp6-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006451": {"description": "Glycogen debranching enzyme, archaeal type", "go_ids": [], "go_terms": [], "name": "Glycogen_debranch_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006452": {"description": "Formate dehydrogenase accessory protein", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "Formate_DH_accessory", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006454": {"description": "S-layer protein", "go_ids": ["GO:0005618"], "go_terms": ["GO:0005618:cell wall:C"], "name": "S_layer_MJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006455": {"description": "Homeodomain, ZF-HD class", "go_ids": [], "go_terms": [], "name": "Homeodomain_ZF_HD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006456": {"description": "ZF-HD homeobox protein, Cys/His-rich dimerisation domain", "go_ids": [], "go_terms": [], "name": "ZF_HD_homeobox_Cys/His_dimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006457": {"description": "S-layer family duplication domain", "go_ids": [], "go_terms": [], "name": "S_layer-rel_Mac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006458": {"description": "Ovate protein family, C-terminal", "go_ids": [], "go_terms": [], "name": "Ovate_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006459": {"description": "Casparian strip membrane protein", "go_ids": [], "go_terms": [], "name": "CASP/CASPL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006460": {"description": "Protein MIZU-KUSSEI 1-like, plant", "go_ids": ["GO:0010274"], "go_terms": ["GO:0010274:hydrotropism:P"], "name": "MIZ1-like_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006461": {"description": "PLAC8 motif-containing protein", "go_ids": [], "go_terms": [], "name": "PLAC_motif_containing", "pathway_ids": ["R-MMU-6798695", "R-BTA-6798695", "R-HSA-9830364", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR006462": {"description": "Protein MS5", "go_ids": [], "go_terms": [], "name": "MS5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006463": {"description": "tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB", "go_ids": ["GO:0006400", "GO:0016740", "GO:0051539"], "go_terms": ["GO:0006400:tRNA modification:P", "GO:0016740:transferase activity:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "MiaB_methiolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006464": {"description": "N-acetyltransferase RimI/Ard1", "go_ids": ["GO:0006474", "GO:0008080"], "go_terms": ["GO:0006474:N-terminal protein amino acid acetylation:P", "GO:0008080:N-acetyltransferase activity:F"], "name": "AcTrfase_RimI/Ard1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006465": {"description": "Oligosaccharide amylase", "go_ids": [], "go_terms": [], "name": "Oligosac_amylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006466": {"description": "MiaB-like tRNA modifying enzyme, archaea/eukaryota", "go_ids": ["GO:0035598", "GO:0035600"], "go_terms": ["GO:0035598:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity:F", "GO:0035600:tRNA methylthiolation:P"], "name": "MiaB-like_arc_euk", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR006467": {"description": "MiaB-like tRNA modifying enzyme, bacteria", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "MiaB-like_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006468": {"description": "Nitrate reductase alpha subunit", "go_ids": ["GO:0008940", "GO:0009325", "GO:0042126"], "go_terms": ["GO:0008940:nitrate reductase activity:F", "GO:0009325:nitrate reductase complex:C", "GO:0042126:nitrate metabolic process:P"], "name": "NarG", "pathway_ids": ["PWY-6748"], "pathways": ["PWY-6748:t:nitrate reduction VII (denitrification)"], "type": "Family"}, "IPR006469": {"description": "NifC-like ABC-type porter", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "NifC_ABC_porter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006470": {"description": "Formate dehydrogenase iron-sulphur subunit, Proteobacteria", "go_ids": ["GO:0015944", "GO:0051539", "GO:0016020", "GO:0045333"], "go_terms": ["GO:0015944:formate oxidation:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0016020:membrane:C", "GO:0045333:cellular respiration:P"], "name": "Formate_DH_bsu_Proteobacteria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006471": {"description": "Formate dehydrogenase, gamma subunit", "go_ids": ["GO:0008863", "GO:0009326", "GO:0016020", "GO:0045333"], "go_terms": ["GO:0008863:formate dehydrogenase (NAD+) activity:F", "GO:0009326:formate dehydrogenase complex:C", "GO:0016020:membrane:C", "GO:0045333:cellular respiration:P"], "name": "Formate_DH_gsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006472": {"description": "Citrate lyase, alpha subunit", "go_ids": ["GO:0005737", "GO:0006084", "GO:0008814", "GO:0009346"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006084:acetyl-CoA metabolic process:P", "GO:0008814:citrate CoA-transferase activity:F", "GO:0009346:ATP-independent citrate lyase complex:C"], "name": "Citrate_lyase_asu", "pathway_ids": ["PWY-6038"], "pathways": ["PWY-6038:t:citrate degradation"], "type": "Family"}, "IPR006473": {"description": "Peptidase C58, YopT-type domain", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "Peptidase_C58_Yopt", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006474": {"description": "Helicase Cas3, CRISPR-associated, core", "go_ids": [], "go_terms": [], "name": "Helicase_Cas3_CRISPR-ass_core", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006475": {"description": "Citrate lyase, beta subunit, bacteria", "go_ids": ["GO:0005737", "GO:0006084", "GO:0008816", "GO:0009346"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006084:acetyl-CoA metabolic process:P", "GO:0008816:citryl-CoA lyase activity:F", "GO:0009346:ATP-independent citrate lyase complex:C"], "name": "Citrate_lyase_beta_bac", "pathway_ids": ["PWY-5392", "PWY-6038"], "pathways": ["PWY-5392:t:reductive TCA cycle II", "PWY-6038:t:citrate degradation"], "type": "Family"}, "IPR006476": {"description": "Conserved hypothetical protein CHP01589, plant", "go_ids": [], "go_terms": [], "name": "CHP01589_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006477": {"description": "Variant antigen yir/bir/cir", "go_ids": [], "go_terms": [], "name": "Yir_bir_cir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006478": {"description": "Formate dehydrogenase, alpha subunit", "go_ids": ["GO:0008863", "GO:0015942"], "go_terms": ["GO:0008863:formate dehydrogenase (NAD+) activity:F", "GO:0015942:formate metabolic process:P"], "name": "Formate_DH_asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006479": {"description": "Holin", "go_ids": [], "go_terms": [], "name": "Holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006480": {"description": "Bacteriophage holin family", "go_ids": [], "go_terms": [], "name": "Phage_holin_4_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006481": {"description": "Bacteriophage lambda, GpS, holin", "go_ids": [], "go_terms": [], "name": "Phage_lambda_GpS_holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006482": {"description": "CRISPR-associated protein Cas7, subtype I-B/I-C", "go_ids": ["GO:0043571"], "go_terms": ["GO:0043571:maintenance of CRISPR repeat elements:P"], "name": "Cas7_Csh2/Csh2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006483": {"description": "CRISPR-associated Cas3-type, HD domain", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Cas3_HD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006484": {"description": "Plasmodium yoelii subtelomeric PYST-B", "go_ids": [], "go_terms": [], "name": "PYST_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006485": {"description": "Bacteriophage-like holin", "go_ids": [], "go_terms": [], "name": "Phage-like_holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006486": {"description": "Plasmodium yoelii subtelomeric PYST-A", "go_ids": [], "go_terms": [], "name": "PYST_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006487": {"description": "Bacteriophage lambda, Tail tip protein L", "go_ids": ["GO:0030430", "GO:0051536", "GO:0046718"], "go_terms": ["GO:0030430:host cell cytoplasm:C", "GO:0051536:iron-sulfur cluster binding:F", "GO:0046718:symbiont entry into host cell:P"], "name": "Phage_lambda_L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006488": {"description": "PYST-C1-like, N-terminal", "go_ids": [], "go_terms": [], "name": "PYST-C1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006489": {"description": "Plasmodium yoelii repeat of length 46", "go_ids": [], "go_terms": [], "name": "PY-rept-46", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006490": {"description": "Phage major tail protein, phi13 family", "go_ids": [], "go_terms": [], "name": "Maj_tail_phi13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006491": {"description": "Plasmodium yoelii subtelomeric PYST-C2", "go_ids": [], "go_terms": [], "name": "PYST_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006492": {"description": "Plasmodium yoelii subtelomeric PYST-D", "go_ids": [], "go_terms": [], "name": "PYST_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006493": {"description": "Holin, BlyA", "go_ids": [], "go_terms": [], "name": "Holin_BlyA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006494": {"description": "Plasmodium subtelomeric PST-A", "go_ids": [], "go_terms": [], "name": "PST_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006495": {"description": "Citrate lyase acyl carrier protein CitD", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "CitD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006496": {"description": "Conserved hypothetical protein CHP01609, Plasmodium spp", "go_ids": [], "go_terms": [], "name": "CHP01606_Plasmodium_spp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006497": {"description": "Bacteriophage lambda, Replication protein O, N-terminal", "go_ids": ["GO:0006260"], "go_terms": ["GO:0006260:DNA replication:P"], "name": "Phage_lambda_VrpO_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006498": {"description": "Tail tube protein", "go_ids": [], "go_terms": [], "name": "Tail_tube", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006499": {"description": "Reticulocyte binding protein", "go_ids": [], "go_terms": [], "name": "Reticulocyte-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006500": {"description": "Helicase, putative, phage/plasmid, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Helicase_put_C_phage/plasmid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006501": {"description": "Pectinesterase inhibitor domain", "go_ids": ["GO:0004857"], "go_terms": ["GO:0004857:enzyme inhibitor activity:F"], "name": "Pectinesterase_inhib_dom", "pathway_ids": ["PWY-7246", "PWY-7248"], "pathways": ["PWY-7246:t:pectin degradation I", "PWY-7248:t:pectin degradation II"], "type": "Domain"}, "IPR006502": {"description": "Protein of unknown function PDDEXK-like", "go_ids": [], "go_terms": [], "name": "PDDEXK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006503": {"description": "Nitrogenase-associated protein", "go_ids": [], "go_terms": [], "name": "Nase-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006504": {"description": "Transcriptional regulator Spx/MgsR", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_Spx/MgsR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006505": {"description": "Phage nucleotide-binding protein", "go_ids": [], "go_terms": [], "name": "Phage_nucleotide-bp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006506": {"description": "Conserved hypothetical protein CHP01619", "go_ids": [], "go_terms": [], "name": "CHP01619", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006507": {"description": "Uncharacterised protein family UPF0283", "go_ids": [], "go_terms": [], "name": "UPF0283", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006508": {"description": "Pseudouridine synthase, RluA-like", "go_ids": [], "go_terms": [], "name": "PsdUridine_synth_RluA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, 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"R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SSC-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-SSC-6803529:r:FGFR2 alternative splicing", "R-SSC-9770562:r:mRNA Polyadenylation", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR006537": {"description": "Cobaltochelatase subunit CobS", "go_ids": [], "go_terms": [], "name": "PD_CobS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006538": {"description": "Cobalt chelatase, CobT subunit", "go_ids": ["GO:0009236"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P"], "name": "CobT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006539": {"description": "P-type ATPase, subfamily IV", "go_ids": ["GO:0000287", "GO:0140326", "GO:0005524", "GO:0015914", "GO:0016020"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0140326:ATPase-coupled intramembrane lipid carrier activity:F", "GO:0005524:ATP binding:F", "GO:0015914:phospholipid transport:P", "GO:0016020:membrane:C"], "name": "P-type_ATPase_IV", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-DRE-936837", "R-XTR-936837", "R-CEL-6798695", "R-SCE-6798695", "R-SPO-936837", "R-HSA-936837", "R-BTA-936837", "R-RNO-936837", "R-SCE-936837", "R-MMU-6798695", "R-MMU-936837", "R-CEL-936837"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-936837:r:Ion transport by P-type ATPases", "R-XTR-936837:r:Ion transport by P-type ATPases", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CEL-936837:r:Ion transport by P-type ATPases"], "type": "Family"}, "IPR006540": {"description": "Bacteriocin, lactococcin 972", "go_ids": [], "go_terms": [], "name": "Lactococcin_972", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006541": {"description": "Bacteriocin-associated integral membrane protein", "go_ids": [], "go_terms": [], "name": "Bacteriocin_ass", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006542": {"description": "Protein of unknown function DUF1093", "go_ids": [], "go_terms": [], "name": "DUF1093", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006543": {"description": "Histidinol-phosphate phosphatase", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "Histidinol-phos", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006544": {"description": "P-type ATPase, subfamily V", "go_ids": ["GO:0016020", "GO:0140358"], "go_terms": ["GO:0016020:membrane:C", "GO:0140358:P-type transmembrane transporter activity:F"], "name": "P-type_TPase_V", "pathway_ids": ["R-SPO-936837", "R-HSA-936837", "R-MMU-936837", "R-CEL-936837", "R-SCE-936837"], "pathways": ["R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases"], "type": "Family"}, "IPR006545": {"description": "EYA domain", "go_ids": ["GO:0007275"], "go_terms": ["GO:0007275:multicellular organism development:P"], "name": "EYA_dom", "pathway_ids": ["R-HSA-9830674", "R-DME-5693565", "R-BTA-5693565", "R-HSA-5693565", "R-MMU-5693565"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR006546": {"description": "Sex-lethal splicing factor", "go_ids": ["GO:0003723", "GO:0000380", "GO:0007530"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0000380:alternative mRNA splicing, via spliceosome:P", "GO:0007530:sex determination:P"], "name": "Sxl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006547": {"description": "Nitrate reductase, beta subunit", "go_ids": ["GO:0008940", "GO:0009325", "GO:0042126"], "go_terms": ["GO:0008940:nitrate reductase activity:F", "GO:0009325:nitrate reductase complex:C", "GO:0042126:nitrate metabolic process:P"], "name": "NO3_Rdtase_bsu", "pathway_ids": ["PWY-6748"], "pathways": ["PWY-6748:t:nitrate reduction VII (denitrification)"], "type": "Family"}, "IPR006548": {"description": "Splicing factor ELAV/Hu", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "ELAD_HU_SF", "pathway_ids": ["R-HSA-450520", "R-RNO-450520", "R-MMU-450520", "R-DME-450520", "R-HSA-9918481"], "pathways": ["R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR006549": {"description": "HAD-superfamily hydrolase,subfamily IIIA", "go_ids": [], "go_terms": [], "name": "HAD-SF_hydro_IIIA", "pathway_ids": ["R-HSA-5649702", "R-MMU-5649702"], "pathways": ["R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "type": "Domain"}, "IPR006550": {"description": "Bifunctional polynucleotide phosphatase/kinase PNKP", "go_ids": ["GO:0046403", "GO:0046404", "GO:0006281"], "go_terms": ["GO:0046403:polynucleotide 3'-phosphatase activity:F", "GO:0046404:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity:F", "GO:0006281:DNA repair:P"], "name": "PNKP", "pathway_ids": ["R-HSA-5649702", "R-MMU-5649702"], "pathways": ["R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "type": "Family"}, "IPR006551": {"description": "Polynucleotide 3'-phosphatase", "go_ids": [], "go_terms": [], "name": "Polynucleotide_phosphatase", "pathway_ids": ["R-HSA-5649702", "R-MMU-5649702"], "pathways": ["R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "type": "Domain"}, "IPR006553": {"description": "Leucine-rich repeat, cysteine-containing subtype", "go_ids": [], "go_terms": [], "name": "Leu-rich_rpt_Cys-con_subtyp", "pathway_ids": ["R-BTA-983168", "R-BTA-8951664", "R-HSA-174178", "R-HSA-187577", "R-HSA-68949", "R-MMU-187577", "R-CFA-8951664", "R-HSA-168928", "R-HSA-8951664", "R-HSA-5689880", "R-DRE-8951664", "R-MMU-68949", "R-HSA-936440", "R-HSA-69231", "R-MMU-174178", "R-CEL-983168", "R-DRE-983168", "R-MMU-8951664", "R-CEL-8854050", "R-MMU-917937", "R-MMU-5689880", "R-MMU-3214842", "R-DRE-917937", "R-MMU-8854050", "R-HSA-8854050", "R-HSA-9708530", "R-HSA-9687136", "R-HSA-390471", "R-HSA-3214842", "R-HSA-9758274", "R-HSA-983168", "R-MMU-9708530", "R-HSA-8939902", "R-MMU-8939902", "R-BTA-917937", "R-RNO-8951664", "R-HSA-917937", "R-MMU-983168", "R-MMU-9758274", "R-RNO-983168", "R-CFA-983168", "R-CEL-8951664", "R-DRE-8854050", "R-MMU-69231"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8951664:r:Neddylation", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-68949:r:Orc1 removal from chromatin", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CFA-8951664:r:Neddylation", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-8951664:r:Neddylation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-917937:r:Iron uptake and transport", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-3214842:r:HDMs demethylate histones", "R-DRE-917937:r:Iron uptake and transport", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-917937:r:Iron uptake and transport", "R-RNO-8951664:r:Neddylation", "R-HSA-917937:r:Iron uptake and transport", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation", "R-DRE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Repeat"}, "IPR006554": {"description": "Helicase-like, DEXD box c2 type", "go_ids": ["GO:0003678", "GO:0016818"], "go_terms": ["GO:0003678:DNA helicase activity:F", "GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F"], "name": "Helicase-like_DEXD_c2", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-MMU-113418", "R-HSA-5693616", "R-HSA-5693579", "R-HSA-427413", "R-BTA-76042", "R-GGA-5693616", "R-DDI-73776", "R-MMU-6804756", "R-DDI-6782210", "R-SPO-6781823", "R-MMU-5693616", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-5685938", "R-MMU-112382", "R-HSA-6781823", "R-MMU-69473", "R-MMU-5696395", "R-HSA-167246", "R-SPO-5696395", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-HSA-9709570", "R-DDI-674695", "R-HSA-5693607", "R-HSA-75953", "R-HSA-77075", "R-MMU-5693568", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-BTA-73863", "R-BTA-75955", "R-SPO-113418", "R-BTA-75953", "R-DDI-73779", "R-BTA-72086", "R-HSA-69473", "R-BTA-6782135", "R-DDI-6781823", "R-DDI-72086", "R-DRE-171319", "R-MMU-674695", "R-SCE-76042", "R-MMU-171319", "R-HSA-167161", "R-HSA-167200", "R-HSA-6804756", "R-HSA-9704331", "R-SCE-674695", "R-HSA-167160", "R-HSA-5696395", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-MMU-73772", "R-MMU-6782210", "R-MMU-72086", "R-GGA-5693607", "R-BTA-73772", "R-BTA-73776", "R-SPO-73776", "R-DDI-113418", "R-HSA-5693554", "R-SCE-6782135", "R-SCE-73776", "R-DDI-6782135", "R-GGA-351465", "R-MMU-73762", "R-GGA-5685938", "R-DDI-5696395", "R-HSA-6781827", "R-HSA-5685942", "R-MMU-6782135", "R-GGA-5685942", "R-BTA-113418", "R-HSA-9704646", "R-HSA-72086", "R-RNO-171319", "R-HSA-171319", "R-HSA-167162", "R-BTA-6781823", "R-MMU-6781823", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696395", "R-MMU-5693579", "R-BTA-5696400", "R-SCE-6782210", "R-HSA-167172", "R-BTA-6796648", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5696400", "R-BTA-73779", "R-SCE-6796648", "R-MMU-5693607", "R-HSA-9701192", "R-BTA-73762", "R-SCE-73779", "R-HSA-2564830", "R-SPO-77075", "R-HSA-381038", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-GGA-5693568", "R-MMU-73863", "R-SCE-6781823", "R-HSA-6782135", "R-BTA-674695", "R-HSA-73762", "R-MMU-5685942", "R-HSA-9709603", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-SPO-5696400", "R-SCE-77075", "R-HSA-75955", "R-SPO-6782210", "R-HSA-5696400", "R-HSA-674695", "R-HSA-76042", "R-SPO-6782135", "R-SCE-73772", "R-DDI-75953", "R-GGA-5693579", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782135:r:Dual incision in TC-NER", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-72086:r:mRNA Capping", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-GGA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-GGA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR006555": {"description": "ATP-dependent helicase, C-terminal", "go_ids": ["GO:0003676", "GO:0005524", "GO:0006139", "GO:0004386", "GO:0016818"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0005524:ATP binding:F", "GO:0006139:nucleobase-containing compound metabolic process:P", "GO:0004386:helicase activity:F", "GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F"], "name": "ATP-dep_Helicase_C", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-MMU-113418", "R-HSA-5693616", "R-HSA-5693579", "R-HSA-427413", "R-BTA-76042", "R-GGA-5693616", "R-DDI-73776", "R-MMU-6804756", "R-DDI-6782210", "R-SPO-6781823", "R-MMU-5693616", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-5685938", "R-MMU-112382", "R-HSA-6781823", "R-MMU-69473", "R-MMU-5696395", "R-HSA-167246", "R-SPO-5696395", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-HSA-9709570", "R-DDI-674695", "R-HSA-5693607", "R-HSA-75953", "R-HSA-77075", "R-MMU-5693568", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-BTA-73863", "R-BTA-75955", "R-SPO-113418", "R-BTA-75953", "R-DDI-73779", "R-BTA-72086", "R-HSA-69473", "R-BTA-6782135", "R-DDI-6781823", "R-DDI-72086", "R-DRE-171319", "R-MMU-674695", "R-SCE-76042", "R-MMU-171319", "R-HSA-167161", "R-HSA-167200", "R-HSA-6804756", "R-HSA-9704331", "R-SCE-674695", "R-HSA-167160", "R-HSA-5696395", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-MMU-73772", "R-MMU-6782210", "R-MMU-72086", "R-GGA-5693607", "R-BTA-73772", "R-BTA-73776", "R-SPO-73776", "R-DDI-113418", "R-HSA-5693554", "R-SCE-6782135", "R-SCE-73776", "R-DDI-6782135", "R-GGA-351465", "R-MMU-73762", "R-GGA-5685938", "R-DDI-5696395", "R-HSA-6781827", "R-HSA-5685942", "R-MMU-6782135", "R-GGA-5685942", "R-BTA-113418", "R-HSA-9704646", "R-HSA-72086", "R-RNO-171319", "R-HSA-171319", "R-HSA-167162", "R-BTA-6781823", "R-MMU-6781823", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696395", "R-MMU-5693579", "R-BTA-5696400", "R-SCE-6782210", "R-HSA-167172", "R-BTA-6796648", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5696400", "R-BTA-73779", "R-SCE-6796648", "R-MMU-5693607", "R-HSA-9701192", "R-BTA-73762", "R-SCE-73779", "R-HSA-2564830", "R-SPO-77075", "R-HSA-381038", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-GGA-5693568", "R-MMU-73863", "R-SCE-6781823", "R-HSA-6782135", "R-BTA-674695", "R-HSA-73762", "R-MMU-5685942", "R-HSA-9709603", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-SPO-5696400", "R-SCE-77075", "R-HSA-75955", "R-SPO-6782210", "R-HSA-5696400", "R-HSA-674695", "R-HSA-76042", "R-SPO-6782135", "R-SCE-73772", "R-DDI-75953", "R-GGA-5693579", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782135:r:Dual incision in TC-NER", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-72086:r:mRNA Capping", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-GGA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-GGA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR006558": {"description": "LamG-like jellyroll fold", "go_ids": [], "go_terms": [], "name": "LamG-like", "pathway_ids": ["R-HSA-6798695", "R-HSA-381426", "R-MMU-381426"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR006560": {"description": "AWS domain", "go_ids": ["GO:0005634", "GO:0042054"], "go_terms": ["GO:0005634:nucleus:C", "GO:0042054:histone methyltransferase activity:F"], "name": "AWS_dom", "pathway_ids": ["R-MMU-69473", "R-HSA-5693571", "R-MMU-3214841", "R-HSA-5693607", "R-HSA-3214841", "R-HSA-69473", "R-HSA-5693565", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR006561": {"description": "DZF domain", "go_ids": [], "go_terms": [], "name": "DZF_dom", "pathway_ids": ["R-DME-9833482", "R-HSA-6798695", "R-MMU-9833482", "R-XTR-9833482", "R-DRE-9762293", "R-XTR-9762293", "R-MMU-9762293", "R-DRE-6798695", "R-HSA-9833482", "R-DME-6798695", "R-MMU-6798695", "R-XTR-6798695", "R-RNO-9833482", "R-DRE-9833482", "R-RNO-6798695", "R-HSA-9762293"], "pathways": ["R-DME-9833482:r:PKR-mediated signaling", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9833482:r:PKR-mediated signaling", "R-XTR-9833482:r:PKR-mediated signaling", "R-DRE-9762293:r:Regulation of CDH11 gene transcription", "R-XTR-9762293:r:Regulation of CDH11 gene transcription", "R-MMU-9762293:r:Regulation of CDH11 gene transcription", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9833482:r:PKR-mediated signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-9833482:r:PKR-mediated signaling", "R-DRE-9833482:r:PKR-mediated signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9762293:r:Regulation of CDH11 gene transcription"], "type": "Domain"}, "IPR006563": {"description": "POX domain", "go_ids": [], "go_terms": [], "name": "POX_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006564": {"description": "Zinc finger, PMZ-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_PMZ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006565": {"description": "Bromodomain associated domain", "go_ids": [], "go_terms": [], "name": "BTP", "pathway_ids": ["R-HSA-6807505", "R-MMU-75953", "R-DRE-73779", "R-XTR-76042", "R-DME-76042", "R-BTA-76042", "R-MMU-6804756", "R-DME-73779", "R-DRE-75953", "R-DRE-6807505", "R-HSA-167162", "R-DME-73776", "R-HSA-73776", "R-BTA-6804756", "R-HSA-75953", "R-MMU-73776", "R-XTR-73779", "R-DME-75953", "R-XTR-75953", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-BTA-73779", "R-DRE-6804756", "R-XTR-674695", "R-BTA-75953", "R-DRE-76042", "R-DME-674695", "R-BTA-6807505", "R-DRE-73776", "R-BTA-674695", "R-MMU-674695", "R-MMU-6807505", "R-DME-6804756", "R-HSA-167161", "R-DME-6807505", "R-HSA-6804756", "R-DRE-674695", "R-XTR-73776", "R-HSA-3214847", "R-HSA-76042", "R-HSA-674695", "R-XTR-6804756", "R-BTA-73776", "R-XTR-6807505", "R-HSA-73779"], "pathways": ["R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-XTR-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-XTR-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-XTR-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR006566": {"description": "FBD domain", "go_ids": [], "go_terms": [], "name": "FBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006568": {"description": "PSP, proline-rich", "go_ids": [], "go_terms": [], "name": "PSP_pro-rich", "pathway_ids": ["R-MMU-9930044", "R-HSA-72163", "R-SPO-9770562", "R-HSA-9930044", "R-HSA-9770562", "R-MMU-72165", "R-MMU-9770562", "R-MMU-72163", "R-HSA-9843970", "R-HSA-72165", "R-DME-9930044", "R-HSA-9918481"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DME-9930044:r:Nuclear RNA decay", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR006569": {"description": "CID domain", "go_ids": [], "go_terms": [], "name": "CID_dom", "pathway_ids": ["R-CEL-6807505", "R-HSA-6807505", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-MMU-77595", "R-MMU-73856", "R-HSA-73856", "R-HSA-72187", "R-CEL-73856", "R-MMU-6807505", "R-CEL-77595", "R-HSA-77595", "R-HSA-72163", "R-SCE-9770562", "R-SCE-6807505", "R-SPO-9770562", "R-MMU-72187", "R-CEL-9770562", "R-BTA-6807505", "R-HSA-9918481"], "pathways": ["R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-9770562:r:mRNA Polyadenylation", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR006570": {"description": "SPK domain", "go_ids": [], "go_terms": [], "name": "SPK_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006571": {"description": "TLDc domain", "go_ids": [], "go_terms": [], "name": "TLDc_dom", "pathway_ids": ["R-RNO-8854214", "R-MMU-9909505", "R-HSA-8854214", "R-MMU-8854214", "R-HSA-9909505"], "pathways": ["R-RNO-8854214:r:TBC/RABGAPs", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-8854214:r:TBC/RABGAPs", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes"], "type": "Domain"}, "IPR006572": {"description": "Zinc finger, DBF-type", "go_ids": ["GO:0003676", "GO:0008270"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0008270:zinc ion binding:F"], "name": "Znf_DBF", "pathway_ids": ["R-DME-68962", "R-SPO-176187", "R-XTR-68962", "R-MMU-68962", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-HSA-176187", "R-SCE-176187", "R-SCE-68962", "R-DME-176187"], "pathways": ["R-DME-68962:r:Activation of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR006573": {"description": "Neuralized homology repeat (NHR) domain", "go_ids": [], "go_terms": [], "name": "NHR_dom", "pathway_ids": ["R-MMU-8951664", "R-HSA-2979096", "R-HSA-2122948", "R-HSA-8951664", "R-HSA-2894862", "R-HSA-2644606", "R-HSA-9013507", "R-HSA-2691232"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-8951664:r:Neddylation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants"], "type": "Domain"}, "IPR006574": {"description": "SPRY-associated", "go_ids": [], "go_terms": [], "name": "PRY", "pathway_ids": ["R-HSA-9833109", "R-BTA-983168", "R-MMU-9909505", "R-HSA-9705671", "R-MMU-3232142", "R-HSA-8851680", "R-HSA-168928", "R-HSA-9833482", "R-HSA-1834941", "R-HSA-5689896", "R-HSA-933542", "R-HSA-9920588", "R-BTA-9755511", "R-HSA-936440", "R-MMU-9755511", "R-HSA-1169408", "R-MMU-8948751", "R-HSA-9909505", "R-HSA-918233", "R-MMU-9833482", "R-HSA-9635465", "R-HSA-9833110", "R-HSA-5656169", "R-BTA-3134975", "R-HSA-445355", "R-HSA-9660826", "R-MMU-3134975", "R-MMU-5656169", "R-HSA-9755511", "R-HSA-983168", "R-MMU-1169408", "R-HSA-3232142", "R-MMU-8851680", "R-HSA-933541", "R-HSA-933543", "R-HSA-877300", "R-HSA-9692916", "R-HSA-3134975", "R-MMU-983168", "R-HSA-8948751", "R-RNO-983168", "R-HSA-844456"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9635465:r:Suppression of apoptosis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Domain"}, "IPR006575": {"description": "RWD domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "RWD_dom", "pathway_ids": ["R-BTA-983168", "R-MMU-9629569", "R-HSA-8866652", "R-HSA-9633012", "R-BTA-8866652", "R-HSA-3065678", "R-MMU-983168", "R-SPO-983168", "R-MMU-9639288", "R-HSA-983168", "R-MMU-8866652", "R-MMU-3065678", "R-HSA-9639288", "R-HSA-9629569", "R-DRE-983168"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9629569:r:Protein hydroxylation", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-9629569:r:Protein hydroxylation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR006576": {"description": "BRK domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "BRK_domain", "pathway_ids": ["PWY-7250", "R-HSA-1989781", "R-DME-9933947", "R-MMU-9933946", "R-HSA-2151201", "R-MMU-1266695", "R-RNO-3214858", "R-MMU-201722", "R-BTA-201722", "R-BTA-9933946", "R-BTA-3247509", "R-HSA-1368108", "R-RNO-8939243", "R-DME-9933939", "R-DME-1266695", "R-HSA-9933387", "R-HSA-9707564", "R-DME-9764725", "R-MMU-3247509", "R-HSA-1266695", "R-DRE-3769402", "R-MMU-9934037", "R-CEL-9933937", "R-HSA-3247509", "R-HSA-9933947", "R-RNO-9934037", "R-HSA-9764725", "R-RNO-9933937", "R-RNO-9933947", "R-MMU-9933939", "R-HSA-8939243", "R-RNO-9764725", "R-HSA-9933937", "R-BTA-8939243", "R-DME-3247509", "R-HSA-400206", "R-MMU-400206", "R-HSA-9818027", "R-CEL-9933947", "R-DME-9933946", "R-DME-8939243", "R-HSA-3769402", "R-RNO-201722", "R-MMU-9933937", "R-HSA-9619665", "R-BTA-9764725", "R-CEL-9934037", "R-DME-9934037", "R-HSA-3214858", "R-BTA-9933937", "R-HSA-9934037", "R-BTA-3214858", "R-BTA-1266695", "R-DME-3214858", "R-HSA-9845323", "R-DME-9933937", "R-BTA-9933939", "R-CEL-9933946", "R-RNO-9933939", "R-HSA-9931509", "R-RNO-9933946", "R-MMU-3769402", "R-RNO-1266695", "R-HSA-381340", "R-BTA-9933947", "R-HSA-9933939", "R-HSA-9707616", "R-MMU-9764725", "R-HSA-9824585", "R-MMU-3214858", "R-MMU-8939243", "R-BTA-9934037", "R-HSA-201722", "R-MMU-9933947", "R-CEL-9764725", "R-CEL-3214858", "R-RNO-3769402", "R-HSA-9933946", "R-RNO-3247509", "R-CEL-9933939", "R-HSA-2426168", "R-MMU-9707564", "R-CEL-8939243"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-MMU-1266695:r:Interleukin-7 signaling", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-BTA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-BTA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-BTA-3247509:r:Chromatin modifying enzymes", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-DME-1266695:r:Interleukin-7 signaling", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-HSA-1266695:r:Interleukin-7 signaling", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-CEL-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-3247509:r:Chromatin modifying enzymes", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-RNO-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-RNO-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-3247509:r:Chromatin modifying enzymes", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-CEL-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-BTA-1266695:r:Interleukin-7 signaling", "R-DME-3214858:r:RMTs methylate histone arginines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-RNO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-RNO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-BTA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9707616:r:Heme signaling", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-CEL-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR006577": {"description": "UAS", "go_ids": [], "go_terms": [], "name": "UAS", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-DDI-9755511", "R-HSA-8951664", "R-MMU-8980692", "R-RNO-8980692", "R-SCE-9755511", "R-HSA-9755511", "R-BTA-6798695", "R-MMU-9755511", "R-XTR-6798695", "R-SPO-9755511", "R-DDI-8951664", "R-SPO-8980692", "R-MMU-8951664", "R-SCE-8951664", "R-XTR-8980692", "R-HSA-8980692", "R-BTA-8980692", "R-SPO-8951664", "R-MMU-6798695", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-XTR-6798695:r:Neutrophil degranulation", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-8951664:r:Neddylation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-8951664:r:Neddylation", "R-SCE-8951664:r:Neddylation", "R-XTR-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-SPO-8951664:r:Neddylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR006578": {"description": "MADF domain", "go_ids": [], "go_terms": [], "name": "MADF-dom", "pathway_ids": ["R-DME-3214815"], "pathways": ["R-DME-3214815:r:HDACs deacetylate histones"], "type": "Domain"}, "IPR006579": {"description": "Pre-C2HC domain", "go_ids": [], "go_terms": [], "name": "Pre_C2HC_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006580": {"description": "Zinc finger, TTF-type", "go_ids": [], "go_terms": [], "name": "Znf_TTF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006581": {"description": "VPS10", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "VPS10", "pathway_ids": ["R-HSA-432722", "R-RNO-432722", "R-HSA-977225", "R-MMU-432722"], "pathways": ["R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR006582": {"description": "MD domain", "go_ids": [], "go_terms": [], "name": "MD_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006583": {"description": "PAN-3 domain", "go_ids": [], "go_terms": [], "name": "PAN-3_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006584": {"description": "Cellulose binding, type IV", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "Cellulose-bd_IV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006585": {"description": "Fucolectin tachylectin-4 pentraxin-1", "go_ids": [], "go_terms": [], "name": "FTP1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006586": {"description": "ADAM, cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "ADAM_Cys-rich", "pathway_ids": ["PWY-8119", "R-HSA-1474228", "R-HSA-6798695", "R-MMU-2534343", "R-HSA-5083635", "R-RNO-1474228", "R-CEL-6798695", "R-HSA-9845619", "R-MMU-9762292", "R-HSA-9845621", "R-HSA-1650814", "R-RNO-8941237", "R-HSA-75892", "R-CEL-1474228", "R-RNO-5173214", "R-HSA-5173214", "R-HSA-2534343", "R-MMU-8941237", "R-HSA-8941237", "R-MMU-5173214", "R-MMU-5682910", "R-HSA-177929", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-5682910", "R-HSA-1442490", "R-MMU-1474228"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-8941237:r:Invadopodia formation", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-MMU-8941237:r:Invadopodia formation", "R-HSA-8941237:r:Invadopodia formation", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR006588": {"description": "Peptide N glycanase, PAW domain", "go_ids": ["GO:0005737", "GO:0006516"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006516:glycoprotein catabolic process:P"], "name": "Peptide_N_glycanase_PAW_dom", "pathway_ids": ["R-HSA-532668", "R-MMU-532668", "R-CEL-532668", "R-DME-532668", "R-DRE-532668", "R-RNO-532668"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "type": "Domain"}, "IPR006590": {"description": "RNA polymerase Rpb4/RPC9, core", "go_ids": [], "go_terms": [], "name": "RNA_pol_Rpb4/RPC9_core", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-MMU-9770562", "R-HSA-73980", "R-DDI-73776", "R-DME-72163", "R-BTA-76071", "R-SPO-6781823", "R-DDI-6782210", "R-DDI-72163", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-BTA-76066", "R-BTA-9018519", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-DME-72203", "R-DDI-674695", "R-DME-72086", "R-MMU-76061", "R-HSA-76061", "R-SPO-6796648", "R-DME-75953", "R-HSA-749476", "R-DME-6782135", "R-BTA-72163", "R-BTA-75955", "R-BTA-75953", "R-SPO-9018519", "R-BTA-6782135", "R-MMU-72163", "R-SPO-76066", "R-HSA-6803529", "R-HSA-167242", "R-HSA-8851708", "R-HSA-167161", "R-HSA-72163", "R-DME-112382", "R-RNO-76061", "R-HSA-9670095", "R-HSA-167160", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-DDI-113418", "R-MMU-72086", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-DME-5578749", "R-DME-77075", "R-DME-73779", "R-BTA-5578749", "R-DME-9770562", "R-DME-73776", "R-BTA-6781823", "R-MMU-6781823", "R-HSA-203927", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-HSA-73780", "R-DDI-76042", "R-MMU-73776", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-HSA-76071", "R-DME-113418", "R-HSA-72203", "R-MMU-6796648", "R-RNO-76071", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-SCE-6781823", "R-MMU-76071", "R-BTA-674695", "R-RNO-76066", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-167290", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-BTA-6807505", "R-BTA-72203", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-BTA-76042", "R-SPO-6807505", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-BTA-76061", "R-HSA-167246", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-HSA-9018519", "R-MMU-76042", "R-HSA-5601884", "R-SPO-75953", "R-SPO-113418", "R-DDI-73779", "R-DME-674695", "R-BTA-72086", "R-DME-9018519", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-MMU-9018519", "R-DME-6807505", "R-SPO-9770562", "R-HSA-167200", "R-DME-72165", "R-SCE-674695", "R-BTA-9770562", "R-MMU-6782210", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-MMU-6782135", "R-HSA-76066", "R-BTA-113418", "R-DME-6796648", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-DDI-76061", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-BTA-112382", "R-SCE-6782210", "R-HSA-9918481", "R-BTA-6796648", "R-SPO-72203", "R-SCE-6796648", "R-SCE-72203", "R-SPO-77075", "R-SCE-113418", "R-SCE-72086", "R-HSA-6782135", "R-SCE-77075", "R-DDI-75953", "R-SPO-6782135"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-72086:r:mRNA Capping", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", 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formation", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-171007:r:p38MAPK events", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-68877:r:Mitotic Prometaphase", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9907900:r:Proteasome assembly", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-1169092:r:Activation of RAS in B cells"], "type": "Conserved_site"}, "IPR006595": {"description": "CTLH, C-terminal LisH motif", "go_ids": [], "go_terms": [], "name": "CTLH_C", "pathway_ids": ["R-DRE-9861718", "R-DDI-9861718", "R-MMU-72163", "R-MMU-9861718", "R-BTA-9861718", "R-DRE-5673001", "R-DME-9861718", "R-HSA-373760", "R-GGA-9861718", "R-HSA-9861718", "R-HSA-5673001", "R-HSA-72163", "R-MMU-8851805", "R-DME-373760", "R-DRE-8851805", "R-CEL-72163", "R-HSA-8851805", "R-MMU-5673001", "R-RNO-9861718", "R-MMU-373760", "R-BTA-72163"], "pathways": ["R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-HSA-373760:r:L1CAM interactions", "R-GGA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-8851805:r:MET activates RAS signaling", "R-DME-373760:r:L1CAM interactions", "R-DRE-8851805:r:MET activates RAS signaling", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-MMU-373760:r:L1CAM interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR006597": {"description": "Sel1-like repeat", "go_ids": [], "go_terms": [], "name": "Sel1-like", "pathway_ids": ["R-HSA-1912420", "R-HSA-9840373", "R-MMU-382556", "R-HSA-9646399", "R-HSA-9931269", "R-HSA-5620924", "R-HSA-901032", "R-HSA-382556", "R-HSA-5678895", "R-RNO-9840373", "R-RNO-9931269", "R-RNO-382556", "R-HSA-5610787", "R-MMU-5358346", "R-MMU-9931269", "R-HSA-5362768", "R-HSA-9613829", "R-HSA-9615710", "R-RNO-5358346", "R-HSA-5358346", "R-MMU-9840373"], "pathways": ["R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-9646399:r:Aggrephagy", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5620924:r:Intraflagellar transport", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-HSA-9615710:r:Late endosomal microautophagy", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9840373:r:Cellular response to mitochondrial stress"], "type": "Repeat"}, "IPR006598": {"description": "Glycosyl transferase CAP10 domain", "go_ids": [], "go_terms": [], "name": "CAP10", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-1912399"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum"], "type": "Domain"}, "IPR006599": {"description": "CARP motif", "go_ids": [], "go_terms": [], "name": "CARP_motif", "pathway_ids": ["R-DDI-6798695", "R-HSA-114608", "R-SPO-6798695", "R-HSA-6798695", "R-DRE-5624138", "R-MMU-5624138", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-5624138", "R-HSA-428890", "R-HSA-389977", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR006600": {"description": "HTH CenpB-type DNA-binding domain", "go_ids": [], "go_terms": [], "name": "HTH_CenpB_DNA-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006601": {"description": "Uncharacterised protein family DM11, Drosophila melanogaster", "go_ids": [], "go_terms": [], "name": "Uncharacterised_DM11_DROME", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006602": {"description": "DM10 domain", "go_ids": [], "go_terms": [], "name": "DM10_dom", "pathway_ids": ["R-BTA-380320", "R-HSA-380320", "R-MMU-380270", "R-HSA-380270", "R-BTA-380270", "R-RNO-380270", "R-MMU-380320", "R-RNO-380320"], "pathways": ["R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes"], "type": "Domain"}, "IPR006603": {"description": "PQ-loop repeat", "go_ids": [], "go_terms": [], "name": "PQ-loop_rpt", "pathway_ids": ["R-MMU-5223345", "R-DME-9959399", "R-DDI-5223345", "R-GGA-5223345", "R-HSA-9959399", "R-CEL-9959399", "R-RNO-5223345", "R-HSA-446193", "R-DME-5223345", "R-CEL-5223345", "R-MMU-446193", "R-SCE-9959399", "R-DME-446193", "R-DDI-9959399", "R-CEL-446193", "R-BTA-9959399", "R-MMU-9959399", "R-SCE-5223345", "R-HSA-5223345", "R-HSA-4687000", "R-BTA-5223345"], "pathways": ["R-MMU-5223345:r:Miscellaneous transport and binding events", "R-DME-9959399:r:SLC-mediated transport of oligopeptides", "R-DDI-5223345:r:Miscellaneous transport and binding events", "R-GGA-5223345:r:Miscellaneous transport and binding events", "R-HSA-9959399:r:SLC-mediated transport of oligopeptides", "R-CEL-9959399:r:SLC-mediated transport of oligopeptides", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DME-5223345:r:Miscellaneous transport and binding events", "R-CEL-5223345:r:Miscellaneous transport and binding events", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-SCE-9959399:r:SLC-mediated transport of oligopeptides", "R-DME-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DDI-9959399:r:SLC-mediated transport of oligopeptides", "R-CEL-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-BTA-9959399:r:SLC-mediated transport of oligopeptides", "R-MMU-9959399:r:SLC-mediated transport of oligopeptides", "R-SCE-5223345:r:Miscellaneous transport and binding events", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-HSA-4687000:r:Defective MPDU1 causes CDG-1f", "R-BTA-5223345:r:Miscellaneous transport and binding events"], "type": "Repeat"}, "IPR006605": {"description": "G2 nidogen/fibulin G2F", "go_ids": [], "go_terms": [], "name": "G2_nidogen/fibulin_G2F", "pathway_ids": ["R-HSA-1474228", "R-RNO-3000157", "R-MMU-3000157", "R-HSA-3000157", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-3000157:r:Laminin interactions", "R-MMU-3000157:r:Laminin interactions", "R-HSA-3000157:r:Laminin interactions", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR006606": {"description": "BBSome complex member BBS5", "go_ids": ["GO:0034464"], "go_terms": ["GO:0034464:BBSome:C"], "name": "BBL5", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-DRE-5620922", "R-HSA-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Family"}, "IPR006607": {"description": "LARP1-like, DM15 repeat", "go_ids": ["GO:0048255", "GO:0000339"], "go_terms": ["GO:0048255:mRNA stabilization:P", "GO:0000339:RNA cap binding:F"], "name": "DM15", "pathway_ids": ["R-HSA-9705671"], "pathways": ["R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses"], "type": "Repeat"}, "IPR006608": {"description": "Coiled-coil and C2 domain-containing protein 1, DM14 domain", "go_ids": [], "go_terms": [], "name": "CC2D1A/B_DM14", "pathway_ids": ["R-DME-9668328", "R-CEL-9668328", "R-HSA-9668328", "R-MMU-9668328", "R-RNO-9668328"], "pathways": ["R-DME-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-CEL-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III"], "type": "Domain"}, "IPR006610": {"description": "Domain of unknown function DM7", "go_ids": [], "go_terms": [], "name": "DM7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006611": {"description": "Protein of unknown function DUF1431, cysteine-rich, Drosophila", "go_ids": [], "go_terms": [], "name": "DUF1431_DROsp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006612": {"description": "THAP-type zinc finger", "go_ids": [], "go_terms": [], "name": "THAP_Znf", "pathway_ids": ["R-CEL-4641265", "R-DME-3214847", "R-DME-9772755", "R-CEL-9764725", "R-DME-6804759", "R-CEL-3769402"], "pathways": ["R-CEL-4641265:r:Repression of WNT target genes", "R-DME-3214847:r:HATs acetylate histones", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex"], "type": "Domain"}, "IPR006614": {"description": "Peroxin/Ferlin domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Peroxin/Ferlin", "pathway_ids": ["R-HSA-445355"], "pathways": ["R-HSA-445355:r:Smooth Muscle Contraction"], "type": "Domain"}, "IPR006615": {"description": "Peptidase C19, ubiquitin-specific peptidase, DUSP domain", "go_ids": ["GO:0004843"], "go_terms": ["GO:0004843:cysteine-type deubiquitinase activity:F"], "name": "Pept_C19_DUSP", "pathway_ids": ["R-HSA-2173788", "R-DRE-5689880", "R-MMU-5357786", "R-HSA-390471", "R-BTA-5357956", "R-BTA-5689880", "R-BTA-5357786", "R-SPO-5656169", "R-HSA-5689880", "R-HSA-9010553", "R-MMU-9010553", "R-RNO-5357905", "R-MMU-5357956", "R-HSA-5357786", "R-RNO-5689880", "R-CEL-5689880", "R-MMU-5689880", "R-BTA-9010553", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357905", "R-RNO-5357956", "R-HSA-5689603", "R-RNO-5357786", "R-XTR-5689880", "R-BTA-5357905"], "pathways": ["R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5689603:r:UCH proteinases", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-XTR-5689880:r:Ub-specific processing proteases", "R-BTA-5357905:r:Regulation of TNFR1 signaling"], "type": "Domain"}, "IPR006616": {"description": "DM9 repeat", "go_ids": [], "go_terms": [], "name": "DM9_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006619": {"description": "Peptidoglycan recognition protein family domain, metazoa/bacteria", "go_ids": ["GO:0008745", "GO:0009253", "GO:0008270"], "go_terms": ["GO:0008745:N-acetylmuramoyl-L-alanine amidase activity:F", "GO:0009253:peptidoglycan catabolic process:P", "GO:0008270:zinc ion binding:F"], "name": "PGRP_domain_met/bac", "pathway_ids": ["R-HSA-6798695", "R-RNO-6803157", "R-DME-214411", "R-BTA-6803157", "R-DME-214397", "R-DME-6798695", "R-DME-209266", "R-BTA-6798695", "R-DME-6803157", "R-HSA-6803157", "R-MMU-6798695", "R-DME-214399", "R-MMU-6803157", "R-DME-214416", "R-RNO-6798695", "R-DME-209171"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-BTA-6803157:r:Antimicrobial peptides", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-209266:r:Peptidoglycan bound PGRP-LC/LE oligomerises", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-MMU-6803157:r:Antimicrobial peptides", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-209171:r:Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE"], "type": "Domain"}, "IPR006620": {"description": "Prolyl 4-hydroxylase, alpha subunit", "go_ids": ["GO:0005506", "GO:0016705", "GO:0031418"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F", "GO:0031418:L-ascorbic acid binding:F"], "name": "Pro_4_hyd_alph", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-RNO-1234176", "R-RNO-1650814", "R-DME-1650814", "R-HSA-9918432", "R-SPO-9629569", "R-DME-9629569", "R-MMU-1234176", "R-HSA-1650814", "R-MMU-9629569", "R-CEL-1234176", "R-MMU-1650814", "R-GGA-1650814", "R-BTA-9629569", "R-CEL-1650814", "R-SCE-9629569", "R-HSA-9629569", "R-HSA-1234176"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-9918432:r:Maturation of DENV proteins", "R-SPO-9629569:r:Protein hydroxylation", "R-DME-9629569:r:Protein hydroxylation", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-9629569:r:Protein hydroxylation", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-GGA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-BTA-9629569:r:Protein hydroxylation", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-SCE-9629569:r:Protein hydroxylation", "R-HSA-9629569:r:Protein hydroxylation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Domain"}, "IPR006621": {"description": "Nose resistant-to-fluoxetine protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Nose-resist-to-fluoxetine_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006623": {"description": "Testicular haploid expressed repeat", "go_ids": [], "go_terms": [], "name": "THEG", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006624": {"description": "Beta-propeller repeat TECPR", "go_ids": [], "go_terms": [], "name": "Beta-propeller_rpt_TECPR", "pathway_ids": ["R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-3108214", "R-HSA-69473", "R-MMU-983168", "R-MMU-3108214", "R-HSA-5693565", "R-HSA-983168", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Repeat"}, "IPR006626": {"description": "Parallel beta-helix repeat", "go_ids": [], "go_terms": [], "name": "PbH1", "pathway_ids": ["R-MMU-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-CEL-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation"], "type": "Repeat"}, "IPR006627": {"description": "TDU repeat", "go_ids": [], "go_terms": [], "name": "TDU_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006628": {"description": "Purine-rich element binding protein family", "go_ids": ["GO:0032422", "GO:0000977"], "go_terms": ["GO:0032422:purine-rich negative regulatory element binding:F", "GO:0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding:F"], "name": "PUR-bd_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006629": {"description": "LPS-induced tumour necrosis factor alpha factor", "go_ids": [], "go_terms": [], "name": "LITAF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006630": {"description": "La-type HTH domain", "go_ids": [], "go_terms": [], "name": "La_HTH", "pathway_ids": ["R-HSA-73980", "R-HSA-749476", "R-HSA-9705671"], "pathways": ["R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses"], "type": "Domain"}, "IPR006631": {"description": "Protein of unknown function DM4/12", "go_ids": [], "go_terms": [], "name": "DM4_12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006633": {"description": "Carbohydrate-binding/sugar hydrolysis domain", "go_ids": [], "go_terms": [], "name": "Carb-bd_sugar_hydrolysis-dom", "pathway_ids": ["R-MMU-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-CEL-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR006634": {"description": "TRAM/LAG1/CLN8 homology domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TLC-dom", "pathway_ids": ["R-HSA-1799339", "R-MMU-1660661", "R-SCE-1660661", "R-SPO-1660661", "R-CEL-1660661", "R-HSA-1660661", "R-BTA-1660661"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis", "R-SCE-1660661:r:Sphingolipid de novo biosynthesis", "R-SPO-1660661:r:Sphingolipid de novo biosynthesis", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Domain"}, "IPR006635": {"description": "NEAT domain", "go_ids": [], "go_terms": [], "name": "NEAT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006636": {"description": "Heat shock chaperonin-binding", "go_ids": [], "go_terms": [], "name": "STI1_HS-bd", "pathway_ids": ["R-SCE-3371497", "R-RNO-3371453", "R-DDI-5696395", "R-BTA-9696273", "R-MMU-8856825", "R-RNO-3371497", "R-HSA-3371497", "R-DDI-8856825", "R-SPO-5696395", "R-MMU-5696395", "R-MMU-5689877", "R-HSA-3371453", "R-RNO-5689877", "R-SPO-8856825", "R-SPO-9696273", "R-RNO-983168", "R-MMU-5696394", "R-MMU-532668", "R-BTA-5696395", "R-HSA-5689877", "R-SCE-9696273", "R-PFA-3371497", "R-MMU-3371453", "R-HSA-532668", "R-DME-3371453", "R-RNO-8856825", "R-BTA-5696394", "R-RNO-5696395", "R-BTA-5689877", "R-SPO-5696394", "R-RNO-9696273", "R-HSA-983168", "R-RNO-5696394", "R-SPO-3371497", "R-XTR-983168", "R-DDI-5696394", "R-RNO-532668", "R-HSA-8856825", "R-HSA-5696395", "R-SCE-8856825", "R-HSA-5696394", "R-MMU-983168", "R-BTA-3371497", "R-BTA-532668", "R-MMU-9696273", "R-CEL-8856825", "R-MMU-3371497", "R-HSA-9696273"], "pathways": ["R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5689877:r:Josephin domain DUBs", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-5689877:r:Josephin domain DUBs", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SPO-9696273:r:RND1 GTPase cycle", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5689877:r:Josephin domain DUBs", "R-SCE-9696273:r:RND1 GTPase cycle", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5689877:r:Josephin domain DUBs", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR006637": {"description": "Clostridial hydrophobic repeat", "go_ids": [], "go_terms": [], "name": "ChW", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006638": {"description": "Elp3/MiaA/NifB-like, radical SAM core domain", "go_ids": ["GO:0051536", "GO:0003824"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F", "GO:0003824:catalytic activity:F"], "name": "Elp3/MiaA/NifB-like_rSAM", "pathway_ids": ["R-DME-947581", "R-HSA-6782315", "R-DME-9857492", "R-PFA-9857492", "R-HSA-909733", "R-MMU-9857492", "R-MMU-947581", "R-DRE-9857492", "R-RNO-9857492", "R-HSA-3214847", "R-SCE-9857492", "R-BTA-9857492", "R-DDI-947581", "R-HSA-9857492", "R-HSA-947581", "R-BTA-947581"], "pathways": ["R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-DME-9857492:r:Protein lipoylation", "R-PFA-9857492:r:Protein lipoylation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-MMU-9857492:r:Protein lipoylation", "R-MMU-947581:r:Molybdenum cofactor biosynthesis", "R-DRE-9857492:r:Protein lipoylation", "R-RNO-9857492:r:Protein lipoylation", "R-HSA-3214847:r:HATs acetylate histones", "R-SCE-9857492:r:Protein lipoylation", "R-BTA-9857492:r:Protein lipoylation", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-9857492:r:Protein lipoylation", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR006639": {"description": "Presenilin/signal peptide peptidase", "go_ids": ["GO:0016020", "GO:0042500"], "go_terms": ["GO:0016020:membrane:C", "GO:0042500:aspartic endopeptidase activity, intramembrane cleaving:F"], "name": "Preselin/SPP", "pathway_ids": ["R-HSA-6798695", "R-MMU-9839383", "R-SSC-1251985", "R-MMU-9707587", "R-HSA-2122948", "R-MMU-3928665", "R-RNO-9017802", "R-CEL-6798695", "R-HSA-1251985", "R-SSC-193692", "R-BTA-9839383", "R-BTA-6798695", "R-RNO-5357905", "R-DRE-193692", "R-RNO-193692", "R-CEL-1251985", "R-HSA-9017802", "R-MMU-193692", "R-DRE-9839383", "R-HSA-2979096", "R-HSA-5357905", "R-HSA-9013700", "R-MMU-9013507", "R-DRE-6798695", "R-RNO-3928665", "R-BTA-1251985", "R-RNO-205043", "R-DME-3928665", "R-HSA-9013507", "R-DME-1251985", "R-MMU-205043", "R-RNO-1251985", "R-HSA-1474228", "R-DDI-6798695", "R-DME-6798695", "R-HSA-205043", "R-HSA-2894862", "R-RNO-9839383", "R-RNO-9013507", "R-HSA-9839383", "R-MMU-9017802", "R-CEL-3928665", "R-MMU-1251985", "R-SSC-9839383", "R-BTA-193692", "R-HSA-3928665", "R-HSA-9707587", "R-SSC-3928665", "R-MMU-5357905", "R-MMU-6798695", "R-DRE-3928665", "R-HSA-2644606", "R-BTA-3928665", "R-DRE-1251985", "R-BTA-205043", "R-HSA-193692", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-SSC-1251985:r:Nuclear signaling by ERBB4", "R-MMU-9707587:r:Regulation of HMOX1 expression and activity", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-193692:r:Regulated proteolysis of p75NTR", "R-BTA-9839383:r:TGFBR3 PTM regulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-DRE-193692:r:Regulated proteolysis of p75NTR", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-DRE-9839383:r:TGFBR3 PTM regulation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-SSC-9839383:r:TGFBR3 PTM regulation", "R-BTA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9707587:r:Regulation of HMOX1 expression and activity", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR006640": {"description": "SprT-like", "go_ids": [], "go_terms": [], "name": "SprT-like_domain", "pathway_ids": ["R-DRE-110320", "R-CEL-110320", "R-RNO-110320", "R-HSA-110320", "R-BTA-110320", "R-XTR-110320", "R-MMU-110320"], "pathways": ["R-DRE-110320:r:Translesion Synthesis by POLH", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-XTR-110320:r:Translesion Synthesis by POLH", "R-MMU-110320:r:Translesion Synthesis by POLH"], "type": "Domain"}, "IPR006641": {"description": "YqgF/RNase H-like domain", "go_ids": ["GO:0006139"], "go_terms": ["GO:0006139:nucleobase-containing compound metabolic process:P"], "name": "YqgF/RNaseH-like_dom", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Domain"}, "IPR006642": {"description": "Rad18, zinc finger UBZ4-type", "go_ids": ["GO:0003677", "GO:0006281"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006281:DNA repair:P"], "name": "Rad18_UBZ4", "pathway_ids": ["R-HSA-5689901", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656169", "R-SPO-5655862", "R-HSA-5696397", "R-MMU-110320", "R-RNO-5693565", "R-MMU-5689901", "R-HSA-5693565", "R-RNO-5689901", "R-HSA-5655862", "R-DRE-6783310", "R-MMU-69473", "R-MMU-5693565", "R-MMU-110314", "R-HSA-5693607", "R-CEL-110320", "R-GGA-353303", "R-HSA-6782210", "R-MMU-5693568", "R-HSA-5656169", "R-HSA-5693568", "R-MMU-5696400", "R-MMU-5693607", "R-MMU-8866654", "R-MMU-5655862", "R-HSA-69473", "R-CEL-5655862", "R-RNO-5693607", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-CEL-6782210", "R-RNO-110320", "R-RNO-5693571", "R-CEL-5696397", "R-HSA-6783310", "R-RNO-69473", "R-XTR-110320", "R-MMU-6783310", "R-GGA-353248", "R-HSA-8866654", "R-DRE-110320", "R-HSA-5693571", "R-SPO-5696400", "R-SPO-110314", "R-CEL-6782135", "R-HSA-5696400", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-BTA-110320", "R-MMU-5693571", "R-HSA-110320", "R-HSA-110314"], "pathways": ["R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5689901:r:Metalloprotease DUBs", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5689901:r:Metalloprotease DUBs", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-XTR-110320:r:Translesion Synthesis by POLH", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-GGA-353248:r:DNA damage recognition in global genomic repair", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex"], "type": "Domain"}, "IPR006643": {"description": "Zasp-like motif", "go_ids": [], "go_terms": [], "name": "Zasp-like_motif", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006644": {"description": "Dystroglycan-type cadherin-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Cadg", "pathway_ids": ["R-MMU-8932505", "R-HSA-8932505", "R-CFA-9939291", "R-HSA-3000178", "R-HSA-8932504", "R-HSA-5083633", "R-HSA-9913351", "R-HSA-3000171", "R-HSA-9619665", "R-HSA-9010553", "R-MMU-9939291", "R-MMU-9010553", "R-CFA-9913351", "R-RNO-9913351", "R-HSA-8932506", "R-MMU-9913351", "R-MMU-8932504", "R-CFA-9010553", "R-CFA-8932506", "R-CFA-8932504", "R-HSA-9939291", "R-HSA-5083629", "R-HSA-5083628", "R-CFA-8932505", "R-MMU-8932506"], 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"R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-72086:r:mRNA Capping", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR006652": {"description": "Kelch repeat type 1", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Kelch_1", "pathway_ids": ["R-BTA-983168", "R-BTA-8951664", "R-DME-983168", "R-DDI-354192", "R-DRE-4641258", "R-GGA-983168", "R-DDI-9755511", "R-HSA-8951664", "R-HSA-5689880", "R-MMU-9861718", "R-DME-8951664", "R-DRE-8951664", "R-SSC-9755511", "R-GGA-8951664", "R-MMU-9755511", "R-SSC-8951664", "R-MMU-9954709", "R-DDI-9013149", "R-DDI-8951664", "R-HSA-9861718", "R-DRE-983168", "R-MMU-8951664", "R-MMU-5689880", "R-DDI-381676", "R-HSA-9954709", "R-HSA-9759194", "R-SSC-5689880", "R-DDI-9013423", "R-DDI-193648", "R-RNO-4641258", "R-DRE-5689880", "R-HSA-381038", "R-DDI-171007", "R-DDI-5658442", "R-RNO-9755511", "R-DDI-392517", "R-DDI-5673001", "R-HSA-9755511", "R-HSA-9679191", "R-HSA-983168", "R-HSA-4641258", "R-RNO-5689880", "R-DRE-9755511", "R-DDI-983168", "R-MMU-4641258", "R-HSA-5658442", "R-DDI-4641258", "R-RNO-8951664", "R-RNO-9954709", "R-MMU-983168", "R-BTA-9954709", "R-RNO-983168", "R-RNO-9861718", "R-DDI-1169092"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8951664:r:Neddylation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-354192:r:Integrin signaling", "R-DRE-4641258:r:Degradation of DVL", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-SSC-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-8951664:r:Neddylation", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-8951664:r:Neddylation", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DDI-8951664:r:Neddylation", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-SSC-5689880:r:Ub-specific processing proteases", "R-DDI-9013423:r:RAC3 GTPase 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nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DDI-1169092:r:Activation of RAS in B cells"], "type": "Repeat"}, "IPR006654": {"description": "Tryptophan synthase, beta chain", "go_ids": ["GO:0004834"], "go_terms": ["GO:0004834:tryptophan synthase activity:F"], "name": "Trp_synth_beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006656": {"description": "Molybdopterin oxidoreductase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Mopterin_OxRdtase", "pathway_ids": ["R-DDI-9837999", "R-RNO-611105", "R-HSA-611105", "R-MMU-9837999", "R-MMU-6799198", "R-BTA-9837999", "R-HSA-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DME-9837999", "R-MMU-611105", "R-HSA-9837999", "R-RNO-9837999", "R-BTA-6799198", "R-DDI-6799198", "R-DME-611105", "R-BTA-611105"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6799198:r:Complex I biogenesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR006657": {"description": "Molybdopterin dinucleotide-binding domain", "go_ids": ["GO:0016491", "GO:0043546"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0043546:molybdopterin cofactor binding:F"], "name": "MoPterin_dinucl-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006658": {"description": "Molybdopterin guanine dinucleotide-containing S/N-oxide reductase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "BisC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006659": {"description": "Arsenate reductase", "go_ids": ["GO:0008794"], "go_terms": ["GO:0008794:arsenate reductase (glutaredoxin) activity:F"], "name": "Arsenate_reductase", "pathway_ids": ["PWY-8259", "PWY-4621", "PWY-8263", "PWY-8264"], "pathways": ["PWY-8259:t:arsenic detoxification (plants)", "PWY-4621:t:arsenic detoxification (bacteria)", "PWY-8263:t:arsenate detoxification III", "PWY-8264:t:arsenate detoxification I"], "type": "Family"}, "IPR006660": {"description": "Arsenate reductase-like", "go_ids": [], "go_terms": [], "name": "Arsenate_reductase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006665": {"description": "OmpA-like domain", "go_ids": [], "go_terms": [], "name": "OmpA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006667": {"description": "SLC41A/MgtE, integral membrane domain", "go_ids": ["GO:0006812", "GO:0008324"], "go_terms": ["GO:0006812:monoatomic cation transport:P", "GO:0008324:monoatomic cation transmembrane transporter activity:F"], "name": "SLC41_membr_dom", "pathway_ids": ["R-MMU-425410", "R-GGA-425410", "R-DRE-425410", "R-HSA-425410"], "pathways": ["R-MMU-425410:r:Metal ion SLC transporters", "R-GGA-425410:r:Metal ion SLC transporters", "R-DRE-425410:r:Metal ion SLC transporters", "R-HSA-425410:r:Metal ion SLC transporters"], "type": "Domain"}, "IPR006668": {"description": "Magnesium transporter, MgtE intracellular domain", "go_ids": [], "go_terms": [], "name": "Mg_transptr_MgtE_intracell_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006669": {"description": "Magnesium transporter MgtE", "go_ids": ["GO:0015693", "GO:0015095", "GO:0016020"], "go_terms": ["GO:0015693:magnesium ion transport:P", "GO:0015095:magnesium ion transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "MgtE_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006671": {"description": "Cyclin, N-terminal", "go_ids": [], "go_terms": [], "name": "Cyclin_N", "pathway_ids": ["R-HSA-69563", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-DME-176408", "R-HSA-8951664", "R-MMU-9754119", "R-HSA-75815", "R-MMU-6804756", "R-DDI-73776", "R-DDI-6782210", "R-MMU-75035", "R-HSA-69231", "R-HSA-9617828", "R-BTA-6804757", "R-RNO-73776", "R-DRE-75955", "R-MMU-1538133", "R-MMU-5689880", "R-HSA-69200", "R-HSA-69656", "R-BTA-68875", "R-BTA-2500257", "R-DME-6804116", "R-SPO-6796648", "R-DRE-69017", "R-RNO-8964046", "R-RNO-5686938", "R-BTA-75955", "R-CEL-6804116", "R-HSA-69478", "R-SPO-9018519", "R-MMU-2173796", "R-RNO-5696395", "R-MMU-3301854", "R-BTA-6804116", "R-RNO-2980767", "R-HSA-8934593", "R-GGA-9754119", "R-DME-1538133", "R-DME-6804756", "R-MMU-171319", "R-CEL-674695", "R-RNO-8963888", "R-RNO-6804757", "R-DME-112382", "R-HSA-6804756", "R-BTA-2559586", "R-RNO-176408", "R-HSA-6804114", "R-CEL-112382", "R-BTA-69017", "R-DME-2559586", "R-SPO-8951664", "R-SPO-73779", "R-RNO-9841922", "R-HSA-68911", "R-DDI-113418", "R-MMU-72086", "R-SPO-73776", "R-RNO-8866423", "R-DME-187577", "R-MMU-187577", "R-RNO-68875", "R-DDI-5696395", "R-DRE-8951936", "R-HSA-2514853", "R-DME-2565942", "R-RNO-69478", "R-MMU-69200", "R-BTA-69563", "R-DRE-983168", "R-MMU-69202", "R-HSA-75035", "R-RNO-2565942", "R-DDI-73772", "R-DDI-6796648", "R-HSA-6782210", "R-RNO-8856828", "R-DDI-76042", "R-MMU-68875", "R-CEL-69273", "R-SCE-73779", "R-MMU-6796648", "R-BTA-187577", "R-DME-69563", "R-HSA-167243", "R-RNO-6796648", "R-DDI-69231", "R-RNO-75955", "R-HSA-381340", "R-SCE-6781823", "R-SPO-69017", "R-DME-174184", "R-BTA-674695", "R-HSA-9634638", "R-MMU-176412", "R-MMU-3214858", "R-HSA-9725371", "R-DME-3301854", "R-HSA-167290", "R-RNO-187577", "R-MMU-174184", "R-MMU-77075", "R-HSA-75955", "R-CEL-2565942", "R-SPO-6782210", "R-CEL-9018519", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-RNO-69017", "R-DME-5689880", "R-DME-69656", "R-BTA-2980767", "R-HSA-167238", "R-BTA-9841922", "R-RNO-2559582", "R-RNO-3000497", "R-RNO-674695", "R-CEL-4419969", "R-HSA-69273", "R-HSA-6796648", "R-DME-68875", "R-BTA-75035", "R-DME-69478", "R-MMU-2565942", "R-HSA-9841922", "R-HSA-6781823", "R-CEL-2980767", "R-RNO-8964038", "R-HSA-167287", "R-MMU-8951664", "R-HSA-167246", "R-SPO-5696395", "R-MMU-5696395", "R-HSA-5693607", "R-RNO-68911", "R-DRE-69231", "R-HSA-6804757", "R-HSA-75953", "R-HSA-77075", "R-HSA-2299718", "R-SPO-72086", "R-HSA-212436", "R-HSA-8951936", "R-RNO-6782210", "R-CEL-69200", "R-DRE-69202", "R-SPO-113418", "R-DRE-9706019", "R-BTA-3301854", "R-SPO-2559582", "R-DME-674695", "R-DDI-73779", "R-DME-9018519", "R-MMU-2559586", "R-DDI-69656", "R-CEL-2173796", "R-DDI-6781823", "R-RNO-5693607", "R-RNO-73762", "R-MMU-6807505", "R-RNO-8939236", "R-SCE-76042", "R-HSA-162658", "R-RNO-381426", "R-DME-6807505", "R-SPO-69202", "R-RNO-174184", "R-CEL-69017", "R-HSA-167200", "R-HSA-4419969", "R-RNO-112382", "R-SSC-9754119", "R-BTA-176408", "R-CEL-9754119", "R-DME-68911", "R-DRE-8878166", "R-RNO-75953", "R-SCE-6782135", "R-RNO-432142", "R-DDI-6782135", "R-RNO-176417", "R-DME-6804114", "R-CEL-69202", "R-RNO-2500257", "R-DRE-69563", "R-MMU-8849470", "R-RNO-171319", "R-BTA-2173796", "R-GGA-2500257", "R-HSA-171319", "R-HSA-2565942", "R-SSC-8934593", "R-BTA-9754119", "R-DRE-2559586", "R-HSA-113418", "R-RNO-69656", "R-BTA-112382", "R-RNO-8852276", "R-CEL-68911", "R-MMU-2995383", "R-CEL-8934593", "R-MMU-2500257", "R-RNO-69202", "R-CEL-6804114", "R-RNO-72086", "R-HSA-2500257", "R-RNO-8856825", "R-RNO-9929491", "R-HSA-9706019", "R-SCE-72086", "R-HSA-2894862", "R-RNO-75035", "R-HSA-983168", "R-HSA-73762", "R-XTR-983168", "R-HSA-69017", "R-SCE-77075", "R-CEL-3214858", "R-GGA-3301854", "R-BTA-4419969", "R-SPO-6782135", "R-DME-176417", "R-HSA-69202", "R-RNO-6781823", "R-DME-69273", "R-HSA-9754119", "R-CEL-8849470", "R-RNO-68949", "R-BTA-8934593", "R-HSA-5689880", "R-HSA-113507", "R-RNO-73779", "R-RNO-3301854", "R-MMU-69017", "R-GGA-2565942", "R-HSA-427413", "R-SSC-69231", "R-RNO-5687128", "R-SPO-6781823", "R-RNO-6804114", "R-DME-75955", "R-BTA-6804114", "R-HSA-167158", "R-MMU-75955", "R-BTA-2299718", "R-MMU-112382", "R-MMU-9706019", "R-BTA-9018519", "R-BTA-69202", "R-MMU-75815", "R-SPO-76042", "R-SCE-6807505", "R-HSA-73776", "R-RNO-6804116", "R-BTA-2565942", "R-DDI-674695", "R-DRE-187577", "R-CEL-69231", "R-HSA-2122947", "R-RNO-69563", "R-HSA-9661069", "R-DME-2559582", "R-HSA-9929491", "R-RNO-176412", "R-DME-174048", "R-DME-69202", "R-RNO-174048", "R-HSA-983231", "R-MMU-2559582", "R-DME-2500257", "R-RNO-5689880", "R-HSA-167161", "R-MMU-69656", "R-DME-69200", "R-RNO-8951936", "R-RNO-8951664", "R-HSA-167160", "R-HSA-5696395", "R-DDI-77075", "R-HSA-174048", "R-MMU-73772", "R-HSA-2644606", "R-MMU-5687128", "R-MMU-69273", "R-DDI-69202", "R-SCE-73776", "R-RNO-2173796", "R-DME-69017", "R-BTA-69478", "R-HSA-68949", "R-RNO-8963901", "R-RNO-9754119", "R-HSA-6781827", "R-CEL-8951936", "R-DME-2995383", "R-MMU-2980767", "R-MMU-8852276", "R-BTA-176412", "R-RNO-8849470", "R-MMU-68949", "R-BTA-176417", "R-MMU-8934593", "R-MMU-8939236", "R-MMU-6781823", "R-CEL-69656", "R-HSA-8849470", "R-CEL-2559586", "R-SPO-69656", "R-CEL-75815", "R-HSA-1538133", "R-MMU-6804116", "R-MMU-73776", "R-DRE-75815", "R-GGA-69273", "R-RNO-9707616", "R-SPO-9754119", "R-HSA-167172", "R-BTA-1538133", "R-MMU-5693607", "R-BTA-212436", "R-HSA-176412", "R-MMU-176408", "R-RNO-113418", "R-CEL-75955", "R-MMU-8951936", "R-MMU-176417", "R-SPO-69231", "R-HSA-156711", "R-MMU-6804757", "R-DME-176412", "R-RNO-75815", "R-HSA-2995383", "R-CEL-176408", "R-XTR-8951664", "R-RNO-69273", "R-CEL-8878166", "R-RNO-69231", "R-SPO-75815", "R-CEL-5689880", "R-SCE-9018519", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-MMU-2299718", "R-BTA-69200", "R-DME-2173796", "R-CEL-69478", "R-SPO-68949", "R-DME-75035", "R-BTA-8878166", "R-BTA-6807505", "R-RNO-3000480", "R-MMU-6804114", "R-HSA-8939236", "R-HSA-112382", "R-HSA-73779", "R-HSA-6804116", "R-HSA-1989781", "R-BTA-69231", "R-RNO-2995383", "R-SCE-75953", "R-MMU-113418", "R-RNO-3214858", "R-CEL-3301854", "R-DME-69231", "R-DRE-8951664", "R-SPO-6807505", "R-CEL-187577", "R-RNO-8964026", "R-RNO-73863", "R-RNO-3000471", "R-DRE-6807505", "R-DRE-6796648", "R-BTA-2995383", "R-RNO-202733", "R-MMU-9929491", "R-HSA-2980767", "R-HSA-8878166", "R-GGA-69231", "R-MMU-73779", "R-HSA-9825892", "R-CEL-69563", "R-HSA-9018519", "R-HSA-176408", "R-RNO-1538133", "R-SPO-75953", "R-MMU-68911", "R-DME-5693607", "R-CEL-2500257", "R-MMU-76042", "R-CEL-6807505", "R-RNO-76042", "R-DRE-1538133", "R-DDI-72086", "R-HSA-6785807", "R-MMU-674695", "R-MMU-8878166", "R-DME-8878166", "R-MMU-69478", "R-GGA-8934593", "R-MMU-9018519", "R-CEL-9929491", "R-HSA-3301854", "R-HSA-2465910", "R-DRE-8934593", "R-SCE-674695", "R-GGA-2995383", "R-MMU-6782210", "R-RNO-4419969", "R-RNO-983168", "R-CEL-6796648", "R-HSA-2559586", "R-MMU-69231", "R-HSA-8853884", "R-MMU-73762", "R-HSA-187577", "R-SPO-176408", "R-HSA-8951430", "R-SPO-5687128", "R-HSA-69205", "R-MMU-6782135", "R-DRE-9754119", "R-RNO-8934593", "R-DRE-6804116", "R-DME-6796648", "R-HSA-72086", "R-HSA-2559582", "R-HSA-68875", "R-HSA-174184", "R-HSA-3214858", "R-MMU-174048", "R-HSA-1912408", "R-HSA-167162", "R-DRE-9929491", "R-CEL-1538133", "R-RNO-8957275", "R-HSA-167152", "R-SPO-983168", "R-RNO-6804756", "R-SPO-3214858", "R-HSA-9833110", "R-RNO-975634", "R-SCE-6782210", "R-RNO-69200", "R-BTA-6796648", "R-HSA-2173796", "R-DME-68949", "R-DME-4419969", "R-SCE-6796648", "R-DRE-8849470", "R-RNO-2299718", "R-RNO-2559586", "R-SPO-77075", "R-BTA-69273", "R-RNO-73772", "R-HSA-390471", "R-HSA-1362300", "R-SCE-113418", "R-BTA-174048", "R-HSA-8852276", "R-RNO-9706019", "R-MMU-73863", "R-DRE-69200", "R-HSA-6782135", "R-RNO-6782135", "R-MMU-69563", "R-CEL-68949", "R-DRE-674695", "R-HSA-5687128", "R-DME-9841922", "R-HSA-176034", "R-MMU-983168", "R-MMU-4419969", "R-DDI-75953", "R-DRE-3214858", "R-HSA-176417", "R-GGA-2980767"], "pathways": ["R-HSA-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8951664:r:Neddylation", "R-MMU-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-1538133:r:G0 and Early G1", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-BTA-68875:r:Mitotic Prophase", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-8964046:r:VLDL clearance", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-69478:r:G2/M DNA replication checkpoint", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-BTA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-RNO-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-GGA-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-DME-1538133:r:G0 and Early G1", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SPO-8951664:r:Neddylation", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-68911:r:G2 Phase", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-8866423:r:VLDL assembly", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68875:r:Mitotic Prophase", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-69478:r:G2/M DNA replication checkpoint", "R-MMU-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-BTA-69563:r:p53-Dependent G1 DNA Damage Response", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-68875:r:Mitotic Prophase", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-75955:r:RNA Polymerase II 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"R-DDI-72086:r:mRNA Capping", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-DME-8878166:r:Transcriptional regulation by RUNX2", "R-MMU-69478:r:G2/M DNA replication checkpoint", "R-GGA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-DRE-8934593:r:Regulation of RUNX1 Expression and Activity", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-GGA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8951430:r:RUNX3 regulates WNT signaling", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DRE-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-RNO-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72086:r:mRNA Capping", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-68875:r:Mitotic Prophase", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-1538133:r:G0 and Early G1", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-HSA-9833110:r:RSV-host interactions", "R-RNO-975634:r:Retinoid metabolism and transport", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-8849470:r:PTK6 Regulates Cell Cycle", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-6782135:r:Dual incision in TC-NER", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-69563:r:p53-Dependent G1 DNA Damage Response", "R-CEL-68949:r:Orc1 removal from chromatin", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-176034:r:Interactions of Tat with host cellular proteins", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-HSA-176417:r:Phosphorylation of Emi1", "R-GGA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7"], "type": "Domain"}, "IPR006673": {"description": "Mnh complex subunit C1", "go_ids": ["GO:0006812", "GO:0008324"], "go_terms": ["GO:0006812:monoatomic cation transport:P", "GO:0008324:monoatomic cation transmembrane transporter activity:F"], "name": "Mnh_C1_su", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006674": {"description": "HD domain", "go_ids": [], "go_terms": [], "name": "HD_domain", "pathway_ids": ["R-BTA-8956319", "R-CEL-8956319", "R-HSA-909733", "R-DDI-8956319", "R-GGA-8956319", "R-DRE-8956319", "R-HSA-8956319", "R-MMU-8956319"], "pathways": ["R-BTA-8956319:r:Nucleotide catabolism", "R-CEL-8956319:r:Nucleotide catabolism", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DDI-8956319:r:Nucleotide catabolism", "R-GGA-8956319:r:Nucleotide catabolism", "R-DRE-8956319:r:Nucleotide catabolism", "R-HSA-8956319:r:Nucleotide catabolism", "R-MMU-8956319:r:Nucleotide catabolism"], "type": "Domain"}, "IPR006675": {"description": "HDIG domain", "go_ids": [], "go_terms": [], "name": "HDIG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006676": {"description": "tRNA-splicing endonuclease", "go_ids": ["GO:0000213", "GO:0006388"], "go_terms": ["GO:0000213:tRNA-intron lyase activity:F", "GO:0006388:tRNA splicing, via endonucleolytic cleavage and ligation:P"], "name": "tRNA_splic", "pathway_ids": ["PWY-7803", "PWY-6689", "R-HSA-6784531"], "pathways": ["PWY-7803:t:tRNA splicing II", "PWY-6689:t:tRNA splicing I", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR006677": {"description": "tRNA intron endonuclease, catalytic domain-like", "go_ids": ["GO:0000213", "GO:0006388"], "go_terms": ["GO:0000213:tRNA-intron lyase activity:F", "GO:0006388:tRNA splicing, via endonucleolytic cleavage and ligation:P"], "name": "tRNA_intron_Endonuc_cat-like", "pathway_ids": ["PWY-7803", "PWY-6689", "R-HSA-6784531"], "pathways": ["PWY-7803:t:tRNA splicing II", "PWY-6689:t:tRNA splicing I", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR006678": {"description": "tRNA intron endonuclease, N-terminal", "go_ids": ["GO:0000213", "GO:0006388"], "go_terms": ["GO:0000213:tRNA-intron lyase activity:F", "GO:0006388:tRNA splicing, via endonucleolytic cleavage and ligation:P"], "name": "tRNA_intron_Endonuc_N", "pathway_ids": ["PWY-7803", "PWY-6689", "R-HSA-6784531"], "pathways": ["PWY-7803:t:tRNA splicing II", "PWY-6689:t:tRNA splicing I", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR006679": {"description": "Adenine deaminase", "go_ids": ["GO:0000034", "GO:0006146"], "go_terms": ["GO:0000034:adenine deaminase activity:F", "GO:0006146:adenine catabolic process:P"], "name": "Adenine_deam", "pathway_ids": ["PWY-6610"], "pathways": ["PWY-6610:t:adenine salvage"], "type": "Family"}, "IPR006680": {"description": "Amidohydrolase-related", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Amidohydro-rel", "pathway_ids": ["R-MMU-500753", "R-HSA-71240", "R-HSA-399956", "R-DDI-73621", "R-BTA-70921", "R-CEL-446210", "R-RNO-74259", "R-RNO-73621", "R-DME-446210", "R-HSA-446210", "R-GGA-437239", "R-HSA-74259", "R-DME-74259", "R-MMU-446210", "R-DRE-446210", "R-XTR-399956", "R-CEL-399956", "R-CEL-500753", "R-BTA-446210", "R-CEL-73621", "R-HSA-70921", "R-RNO-399956", "R-BTA-399956", "R-MMU-437239", "R-HSA-500753", "R-RNO-437239", "R-DDI-70921", "R-HSA-437239", "R-CEL-70921", "R-HSA-73621", "R-DRE-70921", "R-GGA-399956", "R-RNO-446210", "R-DRE-399956", "R-MMU-70921", "R-MMU-74259", "R-SCE-74259", "R-XTR-70921", "R-SPO-74259", "R-MMU-399956", "R-MMU-73621", "R-DDI-74259"], "pathways": ["R-MMU-500753:r:Pyrimidine biosynthesis", "R-HSA-71240:r:Tryptophan catabolism", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-DDI-73621:r:Pyrimidine catabolism", "R-BTA-70921:r:Histidine catabolism", "R-CEL-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-RNO-74259:r:Purine catabolism", "R-RNO-73621:r:Pyrimidine catabolism", "R-DME-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-GGA-437239:r:Recycling pathway of L1", "R-HSA-74259:r:Purine catabolism", "R-DME-74259:r:Purine catabolism", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-DRE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-XTR-399956:r:CRMPs in Sema3A signaling", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-BTA-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-CEL-73621:r:Pyrimidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-MMU-437239:r:Recycling pathway of L1", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-RNO-437239:r:Recycling pathway of L1", "R-DDI-70921:r:Histidine catabolism", "R-HSA-437239:r:Recycling pathway of L1", "R-CEL-70921:r:Histidine catabolism", "R-HSA-73621:r:Pyrimidine catabolism", "R-DRE-70921:r:Histidine catabolism", "R-GGA-399956:r:CRMPs in Sema3A signaling", "R-RNO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-70921:r:Histidine catabolism", "R-MMU-74259:r:Purine catabolism", "R-SCE-74259:r:Purine catabolism", "R-XTR-70921:r:Histidine catabolism", "R-SPO-74259:r:Purine catabolism", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-73621:r:Pyrimidine catabolism", "R-DDI-74259:r:Purine catabolism"], "type": "Domain"}, "IPR006682": {"description": "Conserved hypothetical protein CHP00267", "go_ids": [], "go_terms": [], "name": "CHP00267", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006683": {"description": "Thioesterase domain", "go_ids": [], "go_terms": [], "name": "Thioestr_dom", "pathway_ids": ["R-HSA-165158", "R-RNO-165158", "R-MMU-5218920", "R-RNO-1257604", "R-CEL-77289", "R-MMU-1257604", "R-RNO-5218920", "R-MMU-389357", "R-HSA-5218920", "R-RNO-77289", "R-HSA-199418", "R-MMU-165158", "R-MMU-77289", "R-HSA-389357", "R-SPO-77289", "R-MMU-199418", "R-RNO-199418", "R-HSA-1257604", "R-HSA-77289", "R-RNO-389357"], "pathways": ["R-HSA-165158:r:Activation of AKT2", "R-RNO-165158:r:Activation of AKT2", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-165158:r:Activation of AKT2", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling"], "type": "Domain"}, "IPR006684": {"description": "Acyl-CoA thioester hydrolase YbgC/YbaW family", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "YbgC/YbaW", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis"], "type": "Family"}, "IPR006685": {"description": "Mechanosensitive ion channel MscS", "go_ids": ["GO:0016020", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "MscS_channel_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006687": {"description": "Small GTPase superfamily, SAR1-type", "go_ids": ["GO:0005525", "GO:0006886"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0006886:intracellular protein transport:P"], "name": "Small_GTPase_SAR1", "pathway_ids": ["R-DDI-983170", "R-MMU-204005", "R-RNO-983170", "R-MMU-8963888", "R-HSA-2132295", "R-HSA-9705671", "R-MMU-5694530", "R-CEL-983170", "R-SCE-204005", "R-BTA-8963888", "R-HSA-5694530", "R-SCE-5694530", "R-SSC-2132295", "R-SSC-5694530", "R-MMU-2132295", "R-CEL-204005", "R-BTA-204005", "R-BTA-2132295", "R-SPO-983170", "R-SCE-983170", "R-SSC-8963888", "R-HSA-1655829", "R-DDI-204005", "R-RNO-2132295", "R-RNO-5694530", "R-CEL-5694530", "R-DDI-5694530", "R-SPO-204005", "R-SPO-5694530", "R-HSA-8963888", "R-RNO-204005", "R-BTA-983170", "R-RNO-8963888", "R-HSA-204005", "R-HSA-983170", "R-BTA-5694530", "R-SSC-983170", "R-MMU-983170", "R-SSC-204005"], "pathways": ["R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-BTA-8963888:r:Chylomicron assembly", "R-HSA-5694530:r:Cargo concentration in the ER", "R-SCE-5694530:r:Cargo concentration in the ER", "R-SSC-2132295:r:MHC class II antigen presentation", "R-SSC-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-2132295:r:MHC class II antigen presentation", 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"go_terms": ["GO:0005198:structural molecule activity:F", "GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P", "GO:0030117:membrane coat:C"], "name": "Beta-prop_COPA/B_2nd", "pathway_ids": ["R-SPO-6807878", "R-RNO-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-RNO-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-DDI-6811434", "R-DME-6811434", "R-BTA-6807878", "R-HSA-6811434", "R-DDI-6807878", "R-BTA-6811434", "R-SPO-6811434", "R-DME-6807878", "R-CEL-6811434", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR006693": {"description": "Partial AB-hydrolase lipase domain", "go_ids": ["GO:0006629"], "go_terms": ["GO:0006629:lipid metabolic process:P"], "name": "AB_hydrolase_lipase", "pathway_ids": ["R-CEL-192456", "R-HSA-6809371", "R-CEL-6809371", "R-MMU-192456", "R-DME-6809371", "R-RNO-192456", "R-DME-192456"], "pathways": ["R-CEL-192456:r:Digestion of dietary lipid", "R-HSA-6809371:r:Formation of the cornified envelope", "R-CEL-6809371:r:Formation of the cornified envelope", "R-MMU-192456:r:Digestion of dietary lipid", "R-DME-6809371:r:Formation of the cornified envelope", "R-RNO-192456:r:Digestion of dietary lipid", "R-DME-192456:r:Digestion of dietary lipid"], "type": "Domain"}, "IPR006694": {"description": "Fatty acid hydroxylase", "go_ids": [], "go_terms": [], "name": "Fatty_acid_hydroxylase", "pathway_ids": ["R-DRE-6807047", "R-SPO-6807047", "R-HSA-9969901", "R-DRE-192105", "R-MMU-75109", "R-DDI-6807047", "R-CEL-75109", "R-MMU-192105", "R-RNO-75109", "R-HSA-192105", "R-HSA-1660661", "R-HSA-6807062", "R-DDI-192105", "R-RNO-192105", "R-HSA-6807047", "R-MMU-6807047", "R-SPO-192105", "R-DRE-75109", "R-HSA-75109", "R-SCE-6807047", "R-RNO-1660661", "R-SCE-192105", "R-RNO-6807047", "R-HSA-2426168", "R-XTR-75109", "R-CEL-192105", "R-MMU-1660661"], "pathways": ["R-DRE-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-SPO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-HSA-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-DRE-192105:r:Synthesis of bile acids and bile salts", "R-MMU-75109:r:Triglyceride biosynthesis", "R-DDI-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-CEL-75109:r:Triglyceride biosynthesis", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-RNO-75109:r:Triglyceride biosynthesis", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-DDI-192105:r:Synthesis of bile acids and bile salts", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-HSA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-SPO-192105:r:Synthesis of bile acids and bile salts", "R-DRE-75109:r:Triglyceride biosynthesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-SCE-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-SCE-192105:r:Synthesis of bile acids and bile salts", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-XTR-75109:r:Triglyceride biosynthesis", "R-CEL-192105:r:Synthesis of bile acids and bile salts", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Domain"}, "IPR006696": {"description": "Protein of unknown function DUF423", "go_ids": [], "go_terms": [], "name": "DUF423", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006697": {"description": "RecBCD enzyme subunit RecC", "go_ids": ["GO:0008854", "GO:0009338"], "go_terms": ["GO:0008854:exodeoxyribonuclease V activity:F", "GO:0009338:exodeoxyribonuclease V complex:C"], "name": "RecC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006698": {"description": "Uncharacterised protein family UPF0229", "go_ids": [], "go_terms": [], "name": "UPF0229", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006699": {"description": "Glycerol uptake operon antiterminator", "go_ids": ["GO:0006355", "GO:0006071"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0006071:glycerol metabolic process:P"], "name": "GlpP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006700": {"description": "Ribosomal RNA small subunit methyltransferase E", "go_ids": ["GO:0006364", "GO:0008168"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0008168:methyltransferase activity:F"], "name": "RsmE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006702": {"description": "Casparian strip membrane protein domain", "go_ids": [], "go_terms": [], "name": "CASP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006703": {"description": "AIG1-type guanine nucleotide-binding (G) domain", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "G_AIG1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006704": {"description": "Leukocyte surface antigen CD47", "go_ids": ["GO:0005886", "GO:0070053", "GO:0050729", "GO:0050766", "GO:0022409"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0070053:thrombospondin receptor activity:F", "GO:0050729:positive regulation of inflammatory response:P", "GO:0050766:positive regulation of phagocytosis:P", "GO:0022409:positive regulation of cell-cell adhesion:P"], "name": "CD47", "pathway_ids": ["R-HSA-6798695", "R-SSC-6798695", "R-HSA-216083", "R-RNO-216083", "R-RNO-202733", "R-SSC-391160", "R-MMU-202733", "R-MMU-391160", "R-SSC-216083", "R-MMU-216083", "R-MMU-6798695", "R-RNO-391160", "R-SSC-202733", "R-HSA-202733", "R-RNO-6798695", "R-HSA-391160"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-SSC-216083:r:Integrin cell surface interactions", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-391160:r:Signal regulatory protein family interactions"], "type": "Family"}, "IPR006706": {"description": "Extensin domain", "go_ids": ["GO:0005199", "GO:0009664"], "go_terms": ["GO:0005199:structural constituent of cell wall:F", "GO:0009664:plant-type cell wall organization:P"], "name": "Extensin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006707": {"description": "Type VII secretion system membrane protein EccD", "go_ids": [], "go_terms": [], "name": "T7SS_EccD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006708": {"description": "Pex19 protein", "go_ids": ["GO:0005777"], "go_terms": ["GO:0005777:peroxisome:C"], "name": "Pex19", "pathway_ids": ["R-DDI-1369062", "R-SCE-9603798", "R-BTA-1369062", "R-SCE-1369062", "R-BTA-9603798", "R-SPO-9603798", "R-RNO-9603798", "R-CEL-9603798", "R-CEL-1369062", "R-DDI-9603798", "R-MMU-1369062", "R-MMU-9603798", "R-RNO-1369062", "R-HSA-9603798", "R-HSA-9918481", "R-HSA-1369062"], "pathways": ["R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-1369062:r:ABC transporters in lipid homeostasis", "R-SCE-1369062:r:ABC transporters in lipid homeostasis", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-1369062:r:ABC transporters in lipid homeostasis"], "type": "Family"}, "IPR006709": {"description": "Small-subunit processome, Utp14", "go_ids": ["GO:0006364", "GO:0032040"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0032040:small-subunit processome:C"], "name": "SSU_processome_Utp14", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR006710": {"description": "Glycoside hydrolase, family 43", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro_43", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006711": {"description": "Hox9, N-terminal activation domain", "go_ids": ["GO:0005634", "GO:0006351"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006351:DNA-templated transcription:P"], "name": "Hox9_activation_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006712": {"description": "HD-ZIP protein, N-terminal", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "HD-ZIP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006713": {"description": "Adhesin, Dr-family", "go_ids": [], "go_terms": [], "name": "Adhesin_Dr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006714": {"description": "Flagellar filament outer layer protein FlaA", "go_ids": ["GO:0030288", "GO:0071973"], "go_terms": ["GO:0030288:outer membrane-bounded periplasmic space:C", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "FlaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006715": {"description": "PEA3-type ETS-domain transcription factor, N-terminal", "go_ids": ["GO:0003700", "GO:0005634", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "ETS_PEA3_N", "pathway_ids": ["R-MMU-5687128", "R-HSA-5687128"], "pathways": ["R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Domain"}, "IPR006716": {"description": "ERG2/sigma1 receptor-like", "go_ids": [], "go_terms": [], "name": "ERG2_sigma1_rcpt-like", "pathway_ids": ["R-HSA-9679191"], "pathways": ["R-HSA-9679191:r:Potential therapeutics for SARS"], "type": "Family"}, "IPR006717": {"description": "Adenovirus E1B protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Adeno_E1B_55K_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006718": {"description": "Dec-1 repeat", "go_ids": ["GO:0005213", "GO:0005576", "GO:0007304", "GO:0042600"], "go_terms": ["GO:0005213:structural constituent of egg chorion:F", "GO:0005576:extracellular region:C", "GO:0007304:chorion-containing eggshell formation:P", "GO:0042600:egg chorion:C"], "name": "DEC-1_REPEAT", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006719": {"description": "DEC-1 protein, N-terminal", "go_ids": ["GO:0005213", "GO:0005576", "GO:0007304", "GO:0042600"], "go_terms": ["GO:0005213:structural constituent of egg chorion:F", "GO:0005576:extracellular region:C", "GO:0007304:chorion-containing eggshell formation:P", "GO:0042600:egg chorion:C"], "name": "DEC-1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006720": {"description": "Dec-1 protein, C-terminal", "go_ids": ["GO:0005213", "GO:0005576", "GO:0007304", "GO:0042600"], "go_terms": ["GO:0005213:structural constituent of egg chorion:F", "GO:0005576:extracellular region:C", "GO:0007304:chorion-containing eggshell formation:P", "GO:0042600:egg chorion:C"], "name": "DEC-1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006721": {"description": "ATP synthase, F1 complex, epsilon subunit, mitochondrial", "go_ids": ["GO:0005743", "GO:0015986", "GO:0046933"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C", "GO:0015986:proton motive force-driven ATP synthesis:P", "GO:0046933:proton-transporting ATP synthase activity, rotational mechanism:F"], "name": "ATP_synth_F1_esu_mt", "pathway_ids": ["R-BTA-8949613", "R-MMU-163210", "R-DME-8949613", "R-BTA-163210", "R-DME-163210", "R-RNO-163210", "R-RNO-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-BTA-8949613:r:Cristae formation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-8949613:r:Cristae formation", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR006722": {"description": "Trafficking protein particle complex subunit 2", "go_ids": ["GO:0006888"], "go_terms": ["GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P"], "name": "Sedlin", "pathway_ids": ["R-MMU-204005", "R-DDI-204005", "R-DME-8876198", "R-DRE-204005", "R-RNO-8876198", "R-SPO-204005", "R-SCE-204005", "R-HSA-8876198", "R-SCE-8876198", "R-RNO-204005", "R-DRE-8876198", "R-HSA-204005", "R-MMU-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-CEL-204005", "R-BTA-204005", "R-GGA-204005", "R-SPO-8876198", "R-SSC-204005", "R-DME-204005"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-GGA-204005:r:COPII-mediated vesicle transport", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SSC-204005:r:COPII-mediated vesicle transport", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Family"}, "IPR006723": {"description": "Islet cell autoantigen Ica1, C-terminal", "go_ids": [], "go_terms": [], "name": "Islet_autoAg_Ica1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006724": {"description": "Phage tail tube protein 1", "go_ids": [], "go_terms": [], "name": "Phage_TTP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006725": {"description": "Per os infectivity factor 2", "go_ids": [], "go_terms": [], "name": "PIF2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006726": {"description": "Para-hydroxybenzoic acid efflux pump subunit AaeB/fusaric acid resistance protein", "go_ids": ["GO:0055085", "GO:0022857", "GO:0005886"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F", "GO:0005886:plasma membrane:C"], "name": "PHBA_efflux_AaeB/fusaric-R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006727": {"description": "Herpesvirus BMRF2 protein", "go_ids": [], "go_terms": [], "name": "Herpes_BMRF2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006728": {"description": "Immunity protein YezG-like", "go_ids": [], "go_terms": [], "name": "YezG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006730": {"description": "Sestrin", "go_ids": ["GO:0005634", "GO:1901031"], "go_terms": ["GO:0005634:nucleus:C", "GO:1901031:regulation of response to reactive oxygen species:P"], "name": "Sestrin", "pathway_ids": ["PWY-5292", "R-DDI-9639288", "R-DDI-5628897", "R-DDI-9755511", "R-CEL-9755511", "R-BTA-9755511", "R-CEL-5628897", "R-MMU-9639288", "R-HSA-9755511", "R-MMU-9755511", "R-HSA-9639288", "R-HSA-5628897", "R-BTA-5628897", "R-DME-9755511", "R-MMU-5628897", "R-DME-5628897", "R-BTA-9639288"], "pathways": ["PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR006731": {"description": "Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)", "go_ids": [], "go_terms": [], "name": "Herpes_pp85", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR006732": {"description": "Poxvirus O1", "go_ids": [], "go_terms": [], "name": "Poxvirus_O1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006733": {"description": "Baculovirus occlusion-derived virus envelope, E56", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Baculo_ODV-E56", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006734": {"description": "PLATZ transcription factor", "go_ids": [], "go_terms": [], "name": "PLATZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006735": {"description": "Replication termination factor 2", "go_ids": [], "go_terms": [], "name": "Rtf2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006736": {"description": "Protein of unknown function DUF601", "go_ids": [], "go_terms": [], "name": "DUF601", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006737": {"description": "Motilin/ghrelin-associated peptide", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Motilin_assoc", "pathway_ids": ["R-MMU-422085", "R-BTA-422085", "R-MMU-416476", "R-HSA-375276", "R-CFA-416476", "R-SSC-422085", "R-RNO-422085", "R-HSA-416476", "R-RNO-416476", "R-CFA-422085", "R-HSA-422085", "R-SSC-416476", "R-BTA-416476"], "pathways": ["R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-CFA-416476:r:G alpha (q) signalling events", "R-SSC-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-SSC-416476:r:G alpha (q) signalling events", "R-BTA-416476:r:G alpha (q) signalling events"], "type": "Domain"}, "IPR006738": {"description": "Motilin/ghrelin", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Motilin_ghrelin", "pathway_ids": ["R-MMU-422085", "R-BTA-422085", "R-MMU-416476", "R-HSA-375276", "R-CFA-416476", "R-SSC-422085", "R-RNO-422085", "R-HSA-416476", "R-RNO-416476", "R-CFA-422085", "R-HSA-422085", "R-SSC-416476", "R-BTA-416476"], "pathways": ["R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-CFA-416476:r:G alpha (q) signalling events", "R-SSC-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-SSC-416476:r:G alpha (q) signalling events", "R-BTA-416476:r:G alpha (q) signalling events"], "type": "Domain"}, "IPR006739": {"description": "Protein of unknown function DUF603", "go_ids": [], "go_terms": [], "name": "DUF603", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006740": {"description": "Protein of unknown function DUF604", "go_ids": [], "go_terms": [], "name": "DUF604", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006741": {"description": "Accessory gene regulator B", "go_ids": ["GO:0009372", "GO:0016020", "GO:0008233"], "go_terms": ["GO:0009372:quorum sensing:P", "GO:0016020:membrane:C", "GO:0008233:peptidase activity:F"], "name": "AgrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006742": {"description": "Mating factor alpha, C-terminal repeat", "go_ids": ["GO:0000772", "GO:0005576", "GO:0019953"], "go_terms": ["GO:0000772:mating pheromone activity:F", "GO:0005576:extracellular region:C", "GO:0019953:sexual reproduction:P"], "name": "Mating_factor_alpha_C", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006744": {"description": "Poxvirus A12", "go_ids": [], "go_terms": [], "name": "Poxvirus_A12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006746": {"description": "26S proteasome non-ATPase regulatory subunit Rpn12", "go_ids": ["GO:0005838", "GO:0006508"], "go_terms": ["GO:0005838:proteasome regulatory particle:C", "GO:0006508:proteolysis:P"], "name": "26S_Psome_Rpn12", "pathway_ids": ["R-MMU-450408", "R-HSA-9020702", "R-HSA-174178", "R-HSA-9604323", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-HSA-8951664", "R-HSA-9010553", "R-MMU-174154", "R-MMU-69017", "R-HSA-75815", "R-CEL-8941858", "R-CEL-195253", "R-MMU-9020702", "R-MMU-8948751", "R-MMU-69481", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-CEL-1234176", "R-DDI-9929491", "R-MMU-5668541", "R-HSA-8854050", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-HSA-1234176", "R-HSA-9931269", "R-DDI-174084", "R-HSA-5607761", "R-HSA-9929491", "R-MMU-68867", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-HSA-180534", "R-HSA-1236974", "R-CEL-8948751", "R-CEL-4608870", "R-MMU-5687128", "R-MMU-9766229", "R-DDI-187577", "R-HSA-174154", "R-DDI-382556", "R-HSA-68949", "R-HSA-5610785", "R-MMU-187577", "R-HSA-2467813", "R-MMU-8852276", "R-MMU-68949", "R-CEL-9907900", "R-HSA-9824272", "R-DDI-174178", "R-CEL-983168", "R-MMU-174178", "R-MMU-349425", "R-MMU-8939236", "R-CEL-8854050", "R-HSA-9907900", "R-DDI-69601", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-MMU-9762114", "R-HSA-9762114", "R-DDI-5689880", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-MMU-382556", "R-HSA-5610780", "R-DDI-5687128", "R-CEL-9755511", "R-DDI-9907900", "R-SCE-1236978", "R-MMU-1169091", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-8939902", "R-CEL-5689880", "R-MMU-174184", "R-MMU-8939902", "R-CEL-9762114", "R-HSA-8939236", "R-SPO-350562", "R-CEL-8951664", "R-HSA-5358346", "R-DDI-8854050", "R-MMU-5632684", "R-SPO-9907900", "R-MMU-5607764", "R-MMU-2467813", "R-HSA-9932298", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-DDI-1236978", "R-DDI-5632684", "R-DDI-8951664", "R-MMU-8951664", "R-CEL-382556", "R-CEL-5689603", "R-HSA-4641257", "R-MMU-9929491", "R-HSA-174113", "R-MMU-9929356", "R-SCE-5668541", "R-DDI-174154", "R-HSA-68867", "R-MMU-9907900", "R-HSA-69481", "R-CEL-4641258", "R-DDI-5658442", "R-DDI-8948751", "R-HSA-8941858", "R-HSA-5678895", "R-HSA-9755511", "R-HSA-4641258", "R-CEL-9929491", "R-SPO-5689603", "R-HSA-180585", "R-SPO-1236978", "R-HSA-1169091", "R-CEL-69017", "R-HSA-5658442", "R-HSA-4608870", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-HSA-5689603", "R-MMU-5610780", "R-HSA-187577", "R-DDI-9755511", "R-HSA-349425", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-DDI-75815", "R-MMU-350562", "R-MMU-69601", "R-HSA-2871837", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-MMU-5658442", "R-MMU-5689603", "R-HSA-174084", "R-MMU-4608870", "R-HSA-5607764", "R-DDI-69017", "R-CEL-1236978", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-DDI-983168", "R-SCE-9907900", "R-HSA-5668541", "R-HSA-9929356", "R-CEL-69601", "R-DDI-349425", "R-HSA-5687128", "R-CEL-68949", "R-HSA-69017", "R-MMU-983168", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-HSA-350562", "R-HSA-202424", "R-CEL-4641257"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-1236974:r:ER-Phagosome pathway", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9824272:r:Somitogenesis", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CEL-5689603:r:UCH proteinases", "R-HSA-4641257:r:Degradation of AXIN", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-69481:r:G2/M Checkpoints", "R-CEL-4641258:r:Degradation of DVL", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-5689603:r:UCH proteinases", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-5689603:r:UCH proteinases", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-CEL-4641257:r:Degradation of AXIN"], "type": "Family"}, "IPR006747": {"description": "Protein of unknown function DUF599", "go_ids": [], "go_terms": [], "name": "DUF599", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006748": {"description": "Aminoglycoside/hydroxyurea antibiotic resistance kinase", "go_ids": ["GO:0006468", "GO:0016773", "GO:0019748"], "go_terms": ["GO:0006468:protein phosphorylation:P", "GO:0016773:phosphotransferase activity, alcohol group as acceptor:F", "GO:0019748:secondary metabolic process:P"], "name": "NH2Glyco/OHUrea_AB-resist_kin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006749": {"description": "Pox virus E6 protein", "go_ids": [], "go_terms": [], "name": "Pox_E6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006750": {"description": "Putative inner membrane exporter, YdcZ", "go_ids": [], "go_terms": [], "name": "YdcZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006751": {"description": "TAFII55 protein, conserved region", "go_ids": ["GO:0005669", "GO:0006367"], "go_terms": ["GO:0005669:transcription factor TFIID complex:C", "GO:0006367:transcription initiation at RNA polymerase II promoter:P"], "name": "TAFII55_prot_cons_reg", "pathway_ids": ["R-SCE-73779", "R-SPO-674695", "R-MMU-75953", "R-DME-674695", "R-SCE-75953", "R-DME-76042", "R-MMU-6804756", "R-DME-73779", "R-MMU-674695", "R-SCE-76042", "R-HSA-167162", "R-HSA-167161", "R-DME-6804756", "R-DME-73776", "R-SPO-76042", "R-HSA-73776", "R-HSA-6804756", "R-HSA-73779", "R-SCE-674695", "R-HSA-75953", "R-HSA-167172", "R-SPO-73779", "R-MMU-73776", "R-HSA-76042", "R-HSA-674695", "R-DME-75953", "R-MMU-73779", "R-SPO-73776", "R-MMU-76042", "R-SPO-75953", "R-SCE-73776"], "pathways": ["R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-167172:r:Transcription of the HIV genome", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR006752": {"description": "Archaeal flagella protein FlaD/E domain", "go_ids": ["GO:0097588"], "go_terms": ["GO:0097588:archaeal or bacterial-type flagellum-dependent cell motility:P"], "name": "Arch_fla_DE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006753": {"description": "Nanovirus coat protein", "go_ids": [], "go_terms": [], "name": "Nanovirus_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006754": {"description": "Poxvirus I3 ssDNA-binding", "go_ids": ["GO:0003697"], "go_terms": ["GO:0003697:single-stranded DNA binding:F"], "name": "Poxvirus_I3_ssDNA-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006755": {"description": "Suppressor of silencing P0", "go_ids": ["GO:0016032"], "go_terms": ["GO:0016032:viral process:P"], "name": "Virus_P0", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006756": {"description": "Phenol hydroxylase", "go_ids": ["GO:0018662"], "go_terms": ["GO:0018662:phenol 2-monooxygenase activity:F"], "name": "Phenol_hydroxylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006757": {"description": "Opioid growth factor receptor (OGFr)-like, conserved domain", "go_ids": ["GO:0038023", "GO:0016020"], "go_terms": ["GO:0038023:signaling receptor activity:F", "GO:0016020:membrane:C"], "name": "OGF_rcpt", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006758": {"description": "Poxvirus A32", "go_ids": [], "go_terms": [], "name": "A32L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006759": {"description": "Glycosyl transferase family 54", "go_ids": [], "go_terms": [], "name": "Glyco_transf_54", "pathway_ids": ["PWY-7426", "R-BTA-8957275", "R-RNO-381426", "R-HSA-381426", "R-RNO-975577", "R-DRE-975577", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-9694548", "R-BTA-975577", "R-HSA-975577", "R-HSA-8957275", "R-SSC-975577", "R-MMU-975577", "R-MMU-8957275"], "pathways": ["PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-975577:r:N-Glycan antennae elongation", "R-DRE-975577:r:N-Glycan antennae elongation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9694548:r:Maturation of spike protein", "R-BTA-975577:r:N-Glycan antennae elongation", "R-HSA-975577:r:N-Glycan antennae elongation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-975577:r:N-Glycan antennae elongation", "R-MMU-975577:r:N-Glycan antennae elongation", "R-MMU-8957275:r:Post-translational protein phosphorylation"], "type": "Family"}, "IPR006760": {"description": "Endosulphine", "go_ids": [], "go_terms": [], "name": "Endosulphine", "pathway_ids": ["R-HSA-2465910", "R-GGA-2465910", "R-MMU-2465910", "R-SPO-2465910", "R-BTA-2465910", "R-RNO-2465910", "R-SCE-2465910", "R-SSC-2465910"], "pathways": ["R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-GGA-2465910:r:MASTL Facilitates Mitotic Progression", "R-MMU-2465910:r:MASTL Facilitates Mitotic Progression", "R-SPO-2465910:r:MASTL Facilitates Mitotic Progression", "R-BTA-2465910:r:MASTL Facilitates Mitotic Progression", "R-RNO-2465910:r:MASTL Facilitates Mitotic Progression", "R-SCE-2465910:r:MASTL Facilitates Mitotic Progression", "R-SSC-2465910:r:MASTL Facilitates Mitotic Progression"], "type": "Family"}, "IPR006761": {"description": "Tsg", "go_ids": [], "go_terms": [], "name": "Tsg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006762": {"description": "Gtr1/RagA G protein", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "Gtr1_RagA", "pathway_ids": ["R-RNO-8943724", "R-DDI-165159", "R-SCE-9639288", "R-MMU-380972", "R-MMU-1632852", "R-MMU-9639288", "R-SPO-9639288", "R-BTA-9639288", "R-RNO-8866654", "R-HSA-9639288", "R-HSA-5628897", "R-BTA-380972", "R-RNO-166208", "R-HSA-166208", "R-RNO-1632852", "R-HSA-8943724", "R-MMU-5628897", "R-HSA-380972", "R-BTA-8943724", "R-RNO-165159", "R-MMU-8866654", "R-DDI-9639288", "R-DDI-5628897", "R-DDI-1632852", "R-BTA-166208", "R-MMU-165159", "R-RNO-5628897", "R-DDI-166208", "R-BTA-165159", "R-DDI-380972", "R-BTA-5628897", "R-BTA-1632852", "R-MMU-8943724", "R-HSA-8866654", "R-DDI-8943724", "R-SCE-165159", "R-SPO-165159", "R-RNO-380972", "R-BTA-8866654", "R-HSA-1632852", "R-HSA-165159", "R-RNO-9639288", "R-MMU-166208", "R-DDI-8866654"], "pathways": ["R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-DDI-165159:r:MTOR signalling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-1632852:r:Macroautophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-RNO-1632852:r:Macroautophagy", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-5628897:r:TP53 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"R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-1632852:r:Macroautophagy", "R-HSA-165159:r:MTOR signalling", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-166208:r:mTORC1-mediated signalling", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Family"}, "IPR006763": {"description": "Antigen 332 repeat", "go_ids": [], "go_terms": [], "name": "Ag332", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006764": {"description": "S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type", "go_ids": [], "go_terms": [], "name": "SAM_dep_MeTrfase_SAV2177_type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006765": {"description": "Polyketide synthesis cyclase", "go_ids": ["GO:0030639"], "go_terms": ["GO:0030639:polyketide biosynthetic process:P"], "name": "Polyketide_synth_cyclase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006766": {"description": "Protein EXORDIUM-like", "go_ids": [], "go_terms": [], "name": "EXORDIUM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006767": {"description": "Cwf19-like protein, C-terminal domain-2", "go_ids": [], "go_terms": [], "name": "Cwf19-like_C_dom-2", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR006768": {"description": "Cwf19-like, C-terminal domain-1", "go_ids": [], "go_terms": [], "name": "Cwf19-like_C_dom-1", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR006769": {"description": "Calcium uniporter protein, C-terminal", "go_ids": [], "go_terms": [], "name": "MCU_C", "pathway_ids": ["R-DRE-8949215", "R-HSA-8949215", "R-DDI-8949215", "R-MMU-8949215", "R-CEL-8949664", "R-DME-8949664", "R-HSA-8949664", "R-MMU-8949664", "R-DME-8949215", "R-CEL-8949215"], "pathways": ["R-DRE-8949215:r:Mitochondrial calcium ion transport", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-DDI-8949215:r:Mitochondrial calcium ion transport", "R-MMU-8949215:r:Mitochondrial calcium ion transport", "R-CEL-8949664:r:Processing of SMDT1", "R-DME-8949664:r:Processing of SMDT1", "R-HSA-8949664:r:Processing of SMDT1", "R-MMU-8949664:r:Processing of SMDT1", "R-DME-8949215:r:Mitochondrial calcium ion transport", "R-CEL-8949215:r:Mitochondrial calcium ion transport"], "type": "Domain"}, "IPR006770": {"description": "Opioid growth factor receptor, disordered repeat", "go_ids": [], "go_terms": [], "name": "OGF_rcpt_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006771": {"description": "Secreted thaumatin-like protein cetA-like", "go_ids": [], "go_terms": [], "name": "CetA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006772": {"description": "Herpesvirus BTRF1 protein", "go_ids": [], "go_terms": [], "name": "Herpes_BTRF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006773": {"description": "Proteasomal ubiquitin receptor Rpn13/ADRM1", "go_ids": ["GO:0005634", "GO:0005737"], "go_terms": ["GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C"], "name": "Rpn13/ADRM1", "pathway_ids": ["R-HSA-174178", "R-DRE-4641258", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-HSA-8951664", "R-BTA-9755511", "R-HSA-9010553", "R-CEL-8941858", "R-HSA-75815", "R-DRE-2467813", "R-MMU-8948751", "R-DME-8948751", "R-DRE-8941858", "R-SPO-5689880", "R-MMU-5689880", "R-CEL-1234176", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-DME-5676590", "R-RNO-8854050", "R-HSA-450408", "R-DRE-69017", "R-RNO-450408", "R-HSA-211733", "R-DME-4641257", "R-HSA-5607761", "R-DDI-174084", "R-DRE-8948751", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DRE-9766229", "R-DDI-4641258", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-CEL-8948751", "R-DRE-5610785", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-DDI-187577", "R-RNO-69481", "R-RNO-9932298", "R-DDI-382556", "R-BTA-1236978", "R-DME-202424", "R-DME-187577", "R-RNO-1234176", "R-DRE-195253", "R-RNO-5632684", "R-MMU-187577", "R-DRE-5610780", "R-RNO-174178", "R-DRE-4641257", "R-BTA-4608870", "R-BTA-5676590", "R-HSA-9824272", "R-MMU-174178", "R-MMU-349425", "R-DRE-983168", "R-BTA-2871837", "R-CEL-8854050", "R-HSA-9907900", "R-BTA-174154", "R-DME-350562", "R-DME-174084", "R-DDI-69601", "R-DME-9929491", "R-HSA-9762114", "R-DDI-5689880", "R-HSA-195253", "R-DRE-174178", "R-DRE-5358346", "R-BTA-187577", "R-CEL-9755511", "R-RNO-9755511", "R-DME-8939236", "R-DME-174184", "R-RNO-174113", "R-BTA-9929356", "R-MMU-5676590", "R-MMU-174184", "R-RNO-187577", "R-RNO-68867", "R-RNO-350562", "R-DME-9932298", "R-RNO-9762114", "R-BTA-9954709", "R-DME-9020702", "R-RNO-69017", "R-CEL-9762114", "R-DME-5689880", "R-HSA-5358346", "R-CEL-8951664", "R-SPO-350562", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-BTA-5610785", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-DDI-1236978", "R-DDI-8951664", "R-MMU-8951664", "R-DME-8939902", "R-CEL-5689603", "R-CEL-382556", "R-RNO-174154", "R-MMU-9929356", "R-DME-4608870", "R-RNO-9929356", "R-HSA-69481", "R-DME-9762114", "R-BTA-174084", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DRE-9907900", "R-HSA-4641258", "R-RNO-8939236", "R-SPO-5689603", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-RNO-174184", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", "R-RNO-2467813", "R-DME-5607764", "R-DME-2871837", "R-DME-8941858", "R-DRE-382556", "R-MMU-5610780", "R-DME-9954709", "R-BTA-382556", "R-DRE-9762114", "R-CEL-8939902", "R-MMU-9755511", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-HSA-5362768", "R-DME-5689603", "R-DDI-9954709", "R-MMU-5658442", "R-RNO-8852276", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-DRE-68949", "R-BTA-8948751", "R-RNO-9907900", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-RNO-5607764", "R-RNO-8941858", "R-HSA-69017", "R-RNO-1169091", "R-BTA-9020702", "R-RNO-9766229", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-DRE-68867", "R-HSA-202424", "R-DDI-174154", "R-CEL-4641257", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-DRE-1169091", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-BTA-1234176", "R-MMU-174154", "R-MMU-69017", "R-CEL-195253", "R-DME-5658442", "R-MMU-9020702", "R-RNO-382556", "R-RNO-5687128", "R-DRE-8939236", "R-MMU-69481", "R-BTA-350562", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-DRE-187577", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-BTA-68867", "R-DRE-5668541", "R-DRE-174184", "R-HSA-1234176", "R-RNO-4641258", "R-HSA-9931269", "R-MMU-68867", "R-HSA-9929491", "R-DRE-69601", "R-RNO-5689880", "R-DRE-5689603", "R-DRE-9755511", "R-DME-75815", "R-DRE-350562", "R-RNO-8951664", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-MMU-5687128", "R-DRE-4608870", "R-RNO-5358346", "R-DME-5358346", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-DRE-349425", "R-BTA-195253", "R-DRE-8939902", "R-MMU-8852276", "R-BTA-68949", "R-MMU-68949", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-DME-9907900", "R-RNO-4641257", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-DRE-75815", "R-BTA-174184", "R-RNO-349425", "R-MMU-9762114", "R-MMU-195253", "R-MMU-202424", "R-BTA-8939236", "R-HSA-5610780", "R-MMU-382556", "R-BTA-5632684", "R-DRE-174154", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-RNO-75815", "R-MMU-1169091", "R-MMU-5607761", "R-DME-8854050", "R-CEL-5689880", "R-HSA-8939902", "R-DRE-9932298", "R-MMU-8939902", "R-DME-174178", "R-RNO-195253", "R-HSA-8939236", "R-DRE-8854050", "R-BTA-983168", "R-DDI-8854050", "R-MMU-5607764", "R-DRE-5632684", "R-DME-8951664", "R-DRE-8951664", "R-BTA-5668541", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-DRE-1236978", "R-DRE-9954709", "R-DDI-5632684", "R-BTA-9929491", "R-HSA-4641257", "R-RNO-202424", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9929491", "R-RNO-5607761", "R-HSA-68867", "R-DME-174154", "R-MMU-9907900", "R-CEL-4641258", "R-BTA-450408", "R-DDI-5658442", "R-HSA-8941858", "R-HSA-9755511", "R-DRE-1234176", "R-RNO-9931269", "R-CEL-9929491", "R-DME-9755511", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-DRE-5658442", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-RNO-174084", "R-HSA-5689603", "R-RNO-983168", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DME-1169091", "R-DDI-9755511", "R-DME-382556", "R-BTA-8941858", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-HSA-174184", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-DRE-9929491", "R-BTA-2467813", "R-MMU-5610785", "R-DRE-8852276", "R-DRE-69481", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-DRE-5687128", "R-DRE-5689880", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DRE-174084", "R-DRE-450408", "R-DDI-983168", "R-HSA-5668541", "R-HSA-9929356", "R-CEL-69601", "R-CEL-68949", "R-HSA-5687128", "R-DME-5632684", "R-RNO-5658442", "R-MMU-983168", "R-RNO-5610785", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-4641258:r:Degradation of DVL", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-DRE-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-69481:r:G2/M Checkpoints", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DRE-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-4641257:r:Degradation of AXIN", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-DRE-9907900:r:Proteasome assembly", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-5689603:r:UCH proteinases", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-4641258:r:Degradation of DVL", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-DRE-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DME-5689603:r:UCH proteinases", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DRE-68949:r:Orc1 removal from chromatin", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9907900:r:Proteasome assembly", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome 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"PWY-7897", "PWY-6717", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-6906", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-8435", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-7074", "PWY-8272", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8366", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-842", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-7056", "PWY-7256", "PWY-5400", "PWY-7697", "R-MMU-9840310", "R-RNO-9840310", "R-HSA-9840310", "R-DME-9840310"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-6848:t:rutin degradation", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-8436:t:mammalian high-mannose N-glycan degradation", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-5976:t:dhurrin degradation", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7057:t:cichoriin interconversion", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-7091:t:linustatin bioactivation", "PWY-1901:t:aurone biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-6527:t:stachyose degradation", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-7647:t:ulvan degradation", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-6821:t:kappa-carrageenan degradation", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-6735:t:starch degradation IV", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-6855:t:chitin degradation I (archaea)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-862:t:fructan degradation", "PWY-6737:t:starch degradation V", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-5821:t:dalcochinin biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7134:t:rutin degradation (plants)", "PWY-7133:t:quercetin glucoside degradation (Allium)", "PWY-1921:t:indole-3-acetate activation II", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-7960:t:rhabduscin biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-6717:t:(1,4)-beta-D-xylan degradation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-6906:t:chitin derivatives degradation", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-8435:t:yeast mannan degradation", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-842:t:starch degradation I", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7056:t:daphnin interconversion", "PWY-7256:t:cyanidin diglucoside biosynthesis (acyl-glucose dependent)", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-DME-9840310:r:Glycosphingolipid catabolism"], "type": "Domain"}, "IPR006776": {"description": "Sporulation-specific cell division protein SsgB", "go_ids": ["GO:0051301"], "go_terms": ["GO:0051301:cell division:P"], "name": "SsgB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006777": {"description": "Minor spike protein", "go_ids": ["GO:0046718"], "go_terms": ["GO:0046718:symbiont entry into host cell:P"], "name": "Microvir_H", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006779": {"description": "DNA binding protein S1FA", "go_ids": ["GO:0003677", "GO:0005634", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "S1FA_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006780": {"description": "YABBY protein", "go_ids": ["GO:0007275"], "go_terms": ["GO:0007275:multicellular organism development:P"], "name": "YABBY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006781": {"description": "Apolipoprotein C-I", "go_ids": ["GO:0005576", "GO:0042157"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042157:lipoprotein metabolic process:P"], "name": "ApoC-I", "pathway_ids": ["R-MMU-8866423", "R-MMU-8964046", "R-CFA-8866423", "R-HSA-8866423", "R-RNO-8866423", "R-CFA-8964046", "R-HSA-9029569", "R-RNO-8964046", "R-HSA-8964046"], "pathways": ["R-MMU-8866423:r:VLDL assembly", "R-MMU-8964046:r:VLDL clearance", "R-CFA-8866423:r:VLDL assembly", "R-HSA-8866423:r:VLDL assembly", "R-RNO-8866423:r:VLDL assembly", "R-CFA-8964046:r:VLDL clearance", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-8964046:r:VLDL clearance", "R-HSA-8964046:r:VLDL clearance"], "type": "Family"}, "IPR006782": {"description": "Platelet-derived growth factor, N-terminal", "go_ids": ["GO:0008083", "GO:0016020"], "go_terms": ["GO:0008083:growth factor activity:F", "GO:0016020:membrane:C"], "name": "PDGF_N", "pathway_ids": ["R-HSA-186797", "R-RNO-5673001", "R-MMU-6811558", "R-BTA-5673001", "R-RNO-1257604", "R-HSA-3000171", "R-RNO-186797", "R-HSA-2219530", "R-MMU-1257604", "R-RNO-114608", "R-HSA-5673001", "R-HSA-186763", "R-HSA-6811558", "R-BTA-186763", "R-HSA-114608", "R-RNO-186763", "R-BTA-114608", "R-HSA-9818030", "R-RNO-6811558", "R-BTA-6811558", "R-BTA-186797", "R-BTA-1257604", "R-HSA-1257604", "R-MMU-186797", "R-MMU-5673001", "R-MMU-186763", "R-MMU-114608"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-114608:r:Platelet degranulation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-186763:r:Downstream signal transduction", "R-HSA-114608:r:Platelet degranulation", "R-RNO-186763:r:Downstream signal transduction", "R-BTA-114608:r:Platelet degranulation", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-186797:r:Signaling by PDGF", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR006783": {"description": "Transposase, ISC1217", "go_ids": [], "go_terms": [], "name": "Transposase_ISC1217", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006784": {"description": "Coronavirus Orf3", "go_ids": [], "go_terms": [], "name": "Coronavirus_Orf3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006785": {"description": "Peroxisome membrane anchor protein Pex14/PEX33, N-terminal", "go_ids": [], "go_terms": [], "name": "Pex14/33_N", "pathway_ids": ["R-HSA-8866654", "R-MMU-8866654", "R-SCE-9603798", "R-SPO-9033241", "R-RNO-9033241", "R-SPO-9603798", "R-SCE-9033241", "R-RNO-9603798", "R-DDI-9603798", "R-MMU-9603798", "R-MMU-9033241", "R-RNO-8866654", "R-DDI-9033241", "R-HSA-9603798", "R-HSA-9033241", "R-DDI-8866654"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-9033241:r:Peroxisomal protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Domain"}, "IPR006786": {"description": "Pinin/SDK/MemA protein", "go_ids": [], "go_terms": [], "name": "Pinin_SDK_MemA", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR006787": {"description": "Pinin/SDK", "go_ids": [], "go_terms": [], "name": "Pinin_SDK_N", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR006788": {"description": "Rab effector MyRIP/Melanophilin", "go_ids": [], "go_terms": [], "name": "Myrip/Melanophilin", "pathway_ids": ["R-RNO-9824585", "R-MMU-9824585", "R-HSA-9824585", "R-HSA-264876"], "pathways": ["R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-264876:r:Insulin processing"], "type": "Domain"}, "IPR006789": {"description": "Actin-related protein 2/3 complex subunit 5", "go_ids": ["GO:0015629", "GO:0005885", "GO:0034314"], "go_terms": ["GO:0015629:actin cytoskeleton:C", "GO:0005885:Arp2/3 protein complex:C", "GO:0034314:Arp2/3 complex-mediated actin nucleation:P"], "name": "ARPC5", "pathway_ids": ["R-HSA-5663213", "R-HSA-6798695", "R-DDI-6798695", "R-DDI-2029482", "R-CEL-8856828", "R-SPO-2029482", "R-SPO-6798695", "R-MMU-8856828", "R-HSA-8856828", "R-CEL-6798695", "R-SCE-6798695", "R-DDI-5663213", "R-HSA-2029482", "R-CEL-5663213", "R-SPO-5663213", "R-HSA-3928662", "R-CEL-2029482", "R-RNO-2029482", "R-MMU-2029482", "R-RNO-5663213", "R-MMU-5663213", "R-SCE-5663213", "R-SCE-2029482", "R-RNO-3928662", "R-MMU-3928662", "R-MMU-6798695", "R-RNO-8856828", "R-CEL-3928662", "R-HSA-9664422", "R-RNO-6798695"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SPO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR006790": {"description": "Baculovirus Gp41, glycoprotein", "go_ids": ["GO:0005198", "GO:0044423"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0044423:virion component:C"], "name": "Baculovirus_Gp41", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006791": {"description": "Pox virus D2 protein", "go_ids": [], "go_terms": [], "name": "Pox_D2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006792": {"description": "Vicilin, N-terminal", "go_ids": [], "go_terms": [], "name": "Vicilin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006793": {"description": "FaeA-like protein", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "FaeA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006794": {"description": "Transcriptional activator, Zfx/Zfy domain", "go_ids": ["GO:0003677", "GO:0005634", "GO:0006355", "GO:0046872"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0046872:metal ion binding:F"], "name": "Transcrp_activ_Zfx/Zfy-dom", "pathway_ids": ["R-HSA-212436"], "pathways": ["R-HSA-212436:r:Generic Transcription Pathway"], "type": "Domain"}, "IPR006795": {"description": "Thiostrepton-resistance methylase, N-terminal", "go_ids": ["GO:0008649", "GO:0046677"], "go_terms": ["GO:0008649:rRNA methyltransferase activity:F", "GO:0046677:response to antibiotic:P"], "name": "Thiostrepton-R_Mease_TSNR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006796": {"description": "Dickkopf, N-terminal cysteine-rich", "go_ids": ["GO:0005576", "GO:0007275", "GO:0030178"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0007275:multicellular organism development:P", "GO:0030178:negative regulation of Wnt signaling pathway:P"], "name": "Dickkopf_N", "pathway_ids": ["R-HSA-3772470", "R-HSA-201681", "R-MMU-3772470", "R-HSA-5339717"], "pathways": ["R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-5339717:r:Signaling by LRP5 mutants"], "type": "Domain"}, "IPR006797": {"description": "PRELI/MSF1 domain", "go_ids": [], "go_terms": [], "name": "PRELI/MSF1_dom", "pathway_ids": ["R-DME-6803204", "R-MMU-6803204", "R-HSA-6803204", "R-SPO-6803204", "R-DDI-6803204", "R-HSA-9837999", "R-SCE-6803204", "R-BTA-6803204"], "pathways": ["R-DME-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-SPO-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-DDI-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SCE-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-BTA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "type": "Domain"}, "IPR006798": {"description": "Poxvirus F16", "go_ids": [], "go_terms": [], "name": "Poxvirus_F16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006799": {"description": "Anti-Mullerian hormone, N-terminal", "go_ids": ["GO:0008083", "GO:0008406"], "go_terms": ["GO:0008083:growth factor activity:F", "GO:0008406:gonad development:P"], "name": "AMH_N", "pathway_ids": ["R-MMU-201451", "R-HSA-9690406", "R-HSA-201451", "R-RNO-201451"], "pathways": ["R-MMU-201451:r:Signaling by BMP", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-HSA-201451:r:Signaling by BMP", "R-RNO-201451:r:Signaling by BMP"], "type": "Domain"}, "IPR006800": {"description": "Pellino family", "go_ids": ["GO:0061630", "GO:0000209", "GO:0008592"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0000209:protein polyubiquitination:P", "GO:0008592:regulation of Toll signaling pathway:P"], "name": "Pellino_fam", "pathway_ids": ["PWY-7511", "R-DME-975144", "R-HSA-9020702", "R-MMU-975144", "R-MMU-937039", "R-HSA-975144", "R-HSA-5675482", "R-MMU-5675482", "R-MMU-9020702", "R-DME-9020702", "R-HSA-937039", "R-DME-937039"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-9020702:r:Interleukin-1 signaling", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-DME-937039:r:IRAK1 recruits IKK complex"], "type": "Family"}, "IPR006801": {"description": "Apolipoprotein A-II (ApoA-II)", "go_ids": ["GO:0005576", "GO:0006869", "GO:0008289", "GO:0042157"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006869:lipid transport:P", "GO:0008289:lipid binding:F", "GO:0042157:lipoprotein metabolic process:P"], "name": "ApoA-II", "pathway_ids": ["R-CFA-381426", "R-HSA-1989781", "R-RNO-8963901", "R-MMU-8963888", "R-CFA-8963888", "R-CFA-975634", "R-BTA-8963901", "R-HSA-8963901", "R-HSA-8963888", "R-BTA-975634", "R-BTA-8963888", "R-MMU-8957275", "R-MMU-8963901", "R-RNO-381426", "R-CFA-8963901", "R-MMU-975634", "R-RNO-8963888", "R-BTA-8957275", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-CFA-8957275", "R-HSA-8957275", "R-RNO-975634", "R-HSA-381426", "R-HSA-975634"], "pathways": ["R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-8963901:r:Chylomicron remodeling", "R-MMU-8963888:r:Chylomicron assembly", "R-CFA-8963888:r:Chylomicron assembly", "R-CFA-975634:r:Retinoid metabolism and transport", "R-BTA-8963901:r:Chylomicron remodeling", "R-HSA-8963901:r:Chylomicron remodeling", "R-HSA-8963888:r:Chylomicron assembly", "R-BTA-975634:r:Retinoid metabolism and transport", "R-BTA-8963888:r:Chylomicron assembly", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CFA-8963901:r:Chylomicron remodeling", "R-MMU-975634:r:Retinoid metabolism and transport", "R-RNO-8963888:r:Chylomicron assembly", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Family"}, "IPR006802": {"description": "Radial spokehead-like protein", "go_ids": ["GO:0060271", "GO:0060294", "GO:0001534"], "go_terms": ["GO:0060271:cilium assembly:P", "GO:0060294:cilium movement involved in cell motility:P", "GO:0001534:radial spoke:C"], "name": "Radial_spoke", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006803": {"description": "Poxvirus I5", "go_ids": [], "go_terms": [], "name": "Poxvirus_I5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006804": {"description": "BCL7", "go_ids": [], "go_terms": [], "name": "BCL7", "pathway_ids": ["R-MMU-9933946", "R-MMU-9934037", "R-CEL-9933937", "R-MMU-9933937", "R-HSA-9933947", "R-BTA-9933947", "R-HSA-9933939", "R-CEL-9934037", "R-BTA-9933946", "R-BTA-9933937", "R-HSA-9824585", "R-HSA-9934037", "R-BTA-9934037", "R-MMU-9933939", "R-MMU-9933947", "R-HSA-9845323", "R-HSA-9933937", "R-BTA-9933939", "R-CEL-9933946", "R-HSA-9933946", "R-CEL-9933939", "R-DRE-9933947", "R-CEL-9933947"], "pathways": ["R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-CEL-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-BTA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-CEL-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-DRE-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-CEL-9933947:r:Formation of the non-canonical BAF (ncBAF) complex"], "type": "Family"}, "IPR006806": {"description": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "go_ids": ["GO:0022904"], "go_terms": ["GO:0022904:respiratory electron transport chain:P"], "name": "NDUFA5", "pathway_ids": ["R-BTA-9013408", "R-RNO-611105", "R-HSA-611105", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198", "R-MMU-611105", "R-MMU-9013408", "R-RNO-9013408", "R-HSA-9013408", "R-BTA-6799198", "R-BTA-611105"], "pathways": ["R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR006808": {"description": "ATP synthase F0 complex subunit G, mitochondrial", "go_ids": ["GO:0015078", "GO:0015986"], "go_terms": ["GO:0015078:proton transmembrane transporter activity:F", "GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_F0_gsu_mt", "pathway_ids": ["R-MMU-9837999", "R-CEL-9837999", "R-SCE-9837999", "R-CEL-163210", "R-MMU-163210", "R-HSA-9837999", "R-CEL-8949613", "R-RNO-163210", "R-RNO-8949613", "R-RNO-9837999", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-CEL-8949613:r:Cristae formation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR006809": {"description": "TAFII28-like protein domain", "go_ids": ["GO:0005634", "GO:0006367"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006367:transcription initiation at RNA polymerase II promoter:P"], "name": "TAFII28_dom", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-RNO-6807505", "R-RNO-674695", "R-SCE-75953", "R-MMU-75953", "R-DME-76042", "R-RNO-73779", "R-DDI-73776", "R-MMU-6804756", "R-SPO-6807505", "R-DME-73779", "R-RNO-73776", "R-HSA-167162", "R-SCE-6807505", "R-DME-73776", "R-SPO-76042", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-RNO-6804756", "R-MMU-73776", "R-DDI-76042", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-DME-674695", "R-DDI-73779", "R-RNO-76042", "R-MMU-674695", "R-MMU-6807505", "R-DME-6804756", "R-SCE-76042", "R-HSA-167161", "R-DME-6807505", "R-DDI-6807505", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-674695", "R-HSA-76042", "R-DDI-75953", "R-SPO-73776", "R-RNO-75953", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR006811": {"description": "RNA polymerase II subunit A", "go_ids": ["GO:0004721", "GO:0005634", "GO:0006397"], "go_terms": ["GO:0004721:phosphoprotein phosphatase activity:F", "GO:0005634:nucleus:C", "GO:0006397:mRNA processing:P"], "name": "RNA_pol_II_suA", "pathway_ids": ["R-CEL-6807505", "R-HSA-6807505", "R-GGA-6807505", "R-RNO-6807505", "R-BTA-6807505", "R-MMU-6807505", "R-DRE-6807505", "R-DDI-6807505"], "pathways": ["R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR006812": {"description": "Glycine reductase complex selenoprotein A", "go_ids": ["GO:0030699", "GO:0030700", "GO:0050485"], "go_terms": ["GO:0030699:glycine reductase activity:F", "GO:0030700:glycine reductase complex:C", "GO:0050485:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor:F"], "name": "GRDA", "pathway_ids": ["PWY-8303", "PWY-8015"], "pathways": ["PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-8015:t:glycine degradation (reductive Stickland reaction)"], "type": "Family"}, "IPR006813": {"description": "Glycosyl transferase, family 17", "go_ids": ["GO:0003830", "GO:0016020"], "go_terms": ["GO:0003830:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity:F", "GO:0016020:membrane:C"], "name": "Glyco_trans_17", "pathway_ids": ["PWY-7426", "R-MMU-975574", "R-HSA-975574", "R-RNO-975574"], "pathways": ["PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "R-MMU-975574:r:Reactions specific to the hybrid N-glycan synthesis pathway", "R-HSA-975574:r:Reactions specific to the hybrid N-glycan synthesis pathway", "R-RNO-975574:r:Reactions specific to the hybrid N-glycan synthesis pathway"], "type": "Family"}, "IPR006814": {"description": "Photosystem II PsbR", "go_ids": ["GO:0009654", "GO:0015979", "GO:0042651", "GO:0009523"], "go_terms": ["GO:0009654:photosystem II oxygen evolving complex:C", "GO:0015979:photosynthesis:P", "GO:0042651:thylakoid membrane:C", "GO:0009523:photosystem II:C"], "name": "PSII_PsbR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006815": {"description": "Microvirus J protein-like", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Microvir_J-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006816": {"description": "ELMO domain", "go_ids": [], "go_terms": [], "name": "ELMO_dom", "pathway_ids": ["R-CEL-4420097", "R-CEL-8849471", "R-HSA-164944", "R-DDI-8849471", "R-MMU-9013408", "R-HSA-9013408", "R-HSA-2029482", "R-MMU-4420097", "R-HSA-9664422", "R-MMU-8849471", "R-MMU-2029482", "R-HSA-8849471", "R-HSA-4420097"], "pathways": ["R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-164944:r:Nef and signal transduction", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR006817": {"description": "Lipoprotein leucine-zipper", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "Lipoprotein_leucine-zipper_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006818": {"description": "Histone chaperone ASF1-like", "go_ids": ["GO:0005634", "GO:0006325"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006325:chromatin organization:P"], "name": "ASF1-like", "pathway_ids": ["R-SCE-2559584", "R-BTA-2559584", "R-HSA-2559584", "R-GGA-2559584", "R-MMU-2559584", "R-CEL-2559584"], "pathways": ["R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-BTA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-GGA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Family"}, "IPR006819": {"description": "Agrobacterium VirD5 protein", "go_ids": [], "go_terms": [], "name": "Agro_VirD5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006820": {"description": "Caudal-like activation domain", "go_ids": ["GO:0005634", "GO:0007275", "GO:0006355"], "go_terms": ["GO:0005634:nucleus:C", "GO:0007275:multicellular organism development:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Caudal_activation_dom", "pathway_ids": ["R-HSA-381771"], "pathways": ["R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "type": "Domain"}, "IPR006821": {"description": "Intermediate filament head, DNA-binding domain", "go_ids": ["GO:0005882"], "go_terms": ["GO:0005882:intermediate filament:C"], "name": "Intermed_filament_DNA-bd", "pathway_ids": ["R-HSA-9646399", "R-HSA-9013422", "R-RNO-9013422", "R-BTA-5673001", "R-HSA-1251985", "R-HSA-9918487", "R-HSA-442982", "R-MMU-9013422", "R-CFA-390522", "R-BTA-438066", "R-SSC-9013422", "R-HSA-9615710", "R-CFA-264870", "R-HSA-9617324", "R-MMU-5673001", "R-HSA-9918481", "R-RNO-5673001", "R-RNO-390522", "R-MMU-438066", "R-HSA-9927432", "R-MMU-390522", "R-HSA-6785807", "R-BTA-264870", "R-RNO-438066", "R-BTA-390522", "R-HSA-5673001", "R-BTA-9013422", "R-SSC-390522", "R-MMU-9646399", "R-HSA-438066", "R-HSA-9620244", "R-CFA-9013422", "R-CFA-9646399", "R-MMU-264870", "R-HSA-390522", "R-HSA-9613829", "R-RNO-9646399", "R-SSC-264870", "R-RNO-264870", "R-BTA-9646399", "R-HSA-264870", "R-HSA-9609736", "R-SSC-9646399"], "pathways": ["R-HSA-9646399:r:Aggrephagy", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-390522:r:Striated Muscle Contraction", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-SSC-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9615710:r:Late endosomal microautophagy", "R-CFA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-390522:r:Striated Muscle Contraction", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-BTA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-390522:r:Striated Muscle Contraction", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-SSC-390522:r:Striated Muscle Contraction", "R-MMU-9646399:r:Aggrephagy", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9620244:r:Long-term potentiation", "R-CFA-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-9646399:r:Aggrephagy", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-390522:r:Striated Muscle Contraction", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-RNO-9646399:r:Aggrephagy", "R-SSC-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-BTA-9646399:r:Aggrephagy", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-SSC-9646399:r:Aggrephagy"], "type": "Domain"}, "IPR006822": {"description": "Coatomer, epsilon subunit", "go_ids": ["GO:0005198", "GO:0006890"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0006890:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum:P"], "name": "Coatomer_esu", "pathway_ids": ["R-SPO-6807878", "R-BTA-6807878", "R-HSA-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-DDI-6807878", "R-BTA-6811434", "R-SPO-6811434", "R-GGA-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-DDI-6811434", "R-CEL-6811434", "R-GGA-6811434", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR006823": {"description": "Neutral/alkaline nonlysosomal ceramidase", "go_ids": ["GO:0017040", "GO:0046514"], "go_terms": ["GO:0017040:N-acylsphingosine amidohydrolase activity:F", "GO:0046514:ceramide catabolic process:P"], "name": "Ceramidase_alk", "pathway_ids": ["PWY-6483", "PWY-7119", "R-DDI-9840310", "R-MMU-9840310", "R-RNO-9840310", "R-DME-9840310", "R-DRE-9840310", "R-HSA-9840310"], "pathways": ["PWY-6483:t:ceramide degradation (generic)", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-DME-9840310:r:Glycosphingolipid catabolism", "R-DRE-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Family"}, "IPR006824": {"description": "DNA helicase, Baculovirus", "go_ids": ["GO:0003678", "GO:0019079"], "go_terms": ["GO:0003678:DNA helicase activity:F", "GO:0019079:viral genome replication:P"], "name": "DNA_helicase_Baculovir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006825": {"description": "Eclosion hormone", "go_ids": ["GO:0007218", "GO:0008255", "GO:0018990"], "go_terms": ["GO:0007218:neuropeptide signaling pathway:P", "GO:0008255:ecdysis-triggering hormone activity:F", "GO:0018990:ecdysis, chitin-based cuticle:P"], "name": "Eclosion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006827": {"description": "Lantibiotic dehydratase, N-terminal", "go_ids": [], "go_terms": [], "name": "Lant_deHydtase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006828": {"description": "Association with the SNF1 complex (ASC) domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "ASC_dom", "pathway_ids": ["R-HSA-9619483", "R-MMU-380972", "R-MMU-1632852", "R-MMU-6804756", "R-RNO-163680", "R-HSA-5628897", "R-BTA-380972", "R-RNO-1632852", "R-BTA-6804756", "R-SPO-200425", "R-RNO-200425", "R-MMU-5628897", "R-SPO-163680", "R-RNO-6804756", "R-HSA-9613354", "R-SCE-200425", "R-SCE-163680", "R-HSA-380972", "R-MMU-163680", "R-HSA-9931269", "R-BTA-9931269", "R-SPO-5628897", "R-MMU-200425", "R-SPO-380972", "R-RNO-5628897", "R-RNO-9931269", "R-HSA-2151209", "R-BTA-1632852", "R-BTA-5628897", "R-SCE-1632852", "R-HSA-6804756", "R-HSA-200425", "R-SCE-380972", "R-HSA-1445148", "R-RNO-380972", "R-MMU-9931269", "R-HSA-1632852", "R-SPO-1632852", "R-HSA-163680"], "pathways": ["R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-1632852:r:Macroautophagy", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9613354:r:Lipophagy", "R-SCE-200425:r:Carnitine shuttle", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-200425:r:Carnitine shuttle", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-BTA-1632852:r:Macroautophagy", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-1632852:r:Macroautophagy", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-200425:r:Carnitine shuttle", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity"], "type": "Domain"}, "IPR006829": {"description": "LXG domain", "go_ids": [], "go_terms": [], "name": "LXG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006830": {"description": "InvH outer membrane lipoprotein", "go_ids": [], "go_terms": [], "name": "InvH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006833": {"description": "Ammonia monooxygenase/particulate methane monooxygenase, subunit B", "go_ids": [], "go_terms": [], "name": "NH3_CH4_mOase_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006834": {"description": "VITF-3 subunit protein", "go_ids": [], "go_terms": [], "name": "Pox_A8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006835": {"description": "Domain of unknown function DUF575", "go_ids": [], "go_terms": [], "name": "DUF575", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006836": {"description": "Protein of unknown function DUF612", "go_ids": [], "go_terms": [], "name": "DUF612", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006837": {"description": "Divergent polysaccharide deacetylase", "go_ids": [], "go_terms": [], "name": "Divergent_DAC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006838": {"description": "ADTRP/AIG1", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "ADTRP_AIG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006839": {"description": "Dual-action ribosomal maturation protein DarP", "go_ids": [], "go_terms": [], "name": "DarP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006840": {"description": "Glutathione-specific gamma-glutamylcyclotransferase", "go_ids": ["GO:0006751", "GO:0061928"], "go_terms": ["GO:0006751:glutathione catabolic process:P", "GO:0061928:glutathione specific gamma-glutamylcyclotransferase activity:F"], "name": "ChaC", "pathway_ids": ["PWY-7942", "R-HSA-9648895", "R-RNO-174403", "R-BTA-174403", "R-MMU-174403", "R-SPO-174403", "R-HSA-174403", "R-SCE-174403", "R-DRE-174403"], "pathways": ["PWY-7942:t:5-oxo-L-proline metabolism", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-DRE-174403:r:Glutathione synthesis and recycling"], "type": "Family"}, "IPR006841": {"description": "Coronavirus nonstructural protein NS2", "go_ids": [], "go_terms": [], "name": "Corona_NS2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006842": {"description": "Transposase (putative), YhgA-like", "go_ids": [], "go_terms": [], "name": "Transposase_31", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006843": {"description": "Plastid lipid-associated protein/fibrillin conserved domain", "go_ids": [], "go_terms": [], "name": "PAP/fibrillin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006845": {"description": "Pex, N-terminal", "go_ids": [], "go_terms": [], "name": "Pex_N", "pathway_ids": ["R-MMU-8866654", "R-DME-8866654", "R-BTA-9603798", "R-DME-9033241", "R-SPO-9603798", "R-RNO-9603798", "R-DDI-9603798", "R-MMU-9033241", "R-DME-9603798", "R-RNO-8866654", "R-BTA-9033241", "R-HSA-8866654", "R-RNO-9033241", "R-SCE-9603798", "R-SPO-9033241", "R-BTA-8866654", "R-SCE-9033241", "R-CEL-9603798", "R-MMU-9603798", "R-DDI-9033241", "R-HSA-9603798", "R-HSA-9033241", "R-DDI-8866654"], "pathways": ["R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-DME-9033241:r:Peroxisomal protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-DME-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-9033241:r:Peroxisomal protein import", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-9033241:r:Peroxisomal protein import", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-9033241:r:Peroxisomal protein import", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Domain"}, "IPR006846": {"description": "Small ribosomal subunit protein eS30", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eS30", "pathway_ids": ["R-HSA-9954716", "R-MMU-72689", "R-HSA-9010553", "R-HSA-156827", "R-MMU-72649", "R-HSA-72695", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-MMU-72695", "R-MMU-975956", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-MMU-72702", "R-HSA-9633012", "R-MMU-9954714", "R-MMU-975957", "R-HSA-156902", "R-HSA-72706", "R-HSA-72689", "R-HSA-9735869", "R-HSA-72702", "R-HSA-72764", "R-HSA-9754678", "R-HSA-72649", "R-MMU-156827", "R-HSA-975957", "R-HSA-6791226", "R-HSA-9954714", "R-MMU-1799339"], "pathways": ["R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-192823:r:Viral mRNA Translation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR006847": {"description": "Translation initiation factor IF-2, N-terminal", "go_ids": [], "go_terms": [], "name": "IF2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006848": {"description": "Transcription regulator, putative, lactococcus phage-type", "go_ids": [], "go_terms": [], "name": "Transcrpt_reg_put_lact_phage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006849": {"description": "Elongator complex protein 1", "go_ids": ["GO:0033588", "GO:0002098"], "go_terms": ["GO:0033588:elongator holoenzyme complex:C", "GO:0002098:tRNA wobble uridine modification:P"], "name": "Elp1", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR006850": {"description": "Domain of unknown function DUF562", "go_ids": [], "go_terms": [], "name": "DUF562", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006851": {"description": "Protein of unknown function DUF613", "go_ids": [], "go_terms": [], "name": "DUF613", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006852": {"description": "Alkaline ceramidase TOD1/Probable hexosyltransferase MUCI70", "go_ids": [], "go_terms": [], "name": "TOD1_MUCI70", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006853": {"description": "Poxin, virus", "go_ids": ["GO:0004518"], "go_terms": ["GO:0004518:nuclease activity:F"], "name": "Poxin_vir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006854": {"description": "Phosphoprotein F17", "go_ids": ["GO:0003677", "GO:0019082"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0019082:viral protein processing:P"], "name": "Phosphoprotein_F17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006855": {"description": "Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain", "go_ids": [], "go_terms": [], "name": "Vertebrate-like_GNAT_dom", "pathway_ids": ["PWY-5154", "R-MMU-70635", "R-HSA-70635", "R-SPO-70635", "R-HSA-9955693", "R-DDI-70635", "R-SCE-70635", "R-DRE-70635"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-MMU-70635:r:Urea cycle", "R-HSA-70635:r:Urea cycle", "R-SPO-70635:r:Urea cycle", "R-HSA-9955693:r:NAGS variants cause NAGS deficiency", "R-DDI-70635:r:Urea cycle", "R-SCE-70635:r:Urea cycle", "R-DRE-70635:r:Urea cycle"], "type": "Domain"}, "IPR006856": {"description": "Mating-type protein MAT alpha 1, HMG-box", "go_ids": ["GO:0005634", "GO:0045895", "GO:0007531", "GO:0008301"], "go_terms": ["GO:0005634:nucleus:C", "GO:0045895:positive regulation of mating-type specific transcription, DNA-templated:P", "GO:0007531:mating type determination:P", "GO:0008301:DNA binding, bending:F"], "name": "MATalpha_HMGbox", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006858": {"description": "Chicken anaemia virus VP-3 protein", "go_ids": ["GO:0052151"], "go_terms": ["GO:0052151:symbiont-mediated activation of host apoptosis:P"], "name": "CAV_VP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006859": {"description": "Influenza B matrix protein 2", "go_ids": ["GO:1902600", "GO:0016020"], "go_terms": ["GO:1902600:proton transmembrane transport:P", "GO:0016020:membrane:C"], "name": "Flu_B_M2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006860": {"description": "FecR protein", "go_ids": [], "go_terms": [], "name": "FecR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006861": {"description": "Hyaluronan/mRNA-binding protein", "go_ids": [], "go_terms": [], "name": "HABP4_PAIRBP1-bd", "pathway_ids": ["R-HSA-114608", "R-SCE-114608", "R-DRE-114608", "R-DDI-114608", "R-SPO-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-SCE-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-DDI-114608:r:Platelet degranulation", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR006862": {"description": "Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase", "go_ids": [], "go_terms": [], "name": "Thio_Ohase/aa_AcTrfase", "pathway_ids": ["PWY-7723", "PWY-6733", "PWY-1121", "PWY-321", "PWY-5996", "PWY-5972", "R-MMU-9837999", "R-MMU-193368", "R-HSA-9918432", "R-HSA-193368", "R-MMU-9033241", "R-RNO-9837999", "R-RNO-9033241", "R-MMU-159418", "R-RNO-159418", "R-RNO-77289", "R-HSA-390247", "R-MMU-77289", "R-RNO-193368", "R-MMU-390247", "R-HSA-159418", "R-HSA-9837999", "R-HSA-9033241", "R-HSA-77289"], "pathways": ["PWY-7723:t:bacterial bioluminescence", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-1121:t:suberin monomers biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-5996:t:oleate biosynthesis II (animals and fungi)", "PWY-5972:t:stearate biosynthesis I (animals)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-159418:r:Recycling of bile acids and salts", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation"], "type": "Domain"}, "IPR006864": {"description": "LMP repeat", "go_ids": [], "go_terms": [], "name": "LMP_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006865": {"description": "Domain of unknown function DUF629", "go_ids": [], "go_terms": [], "name": "DUF629", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006866": {"description": "Domain of unknown function DUF627, N-terminal", "go_ids": [], "go_terms": [], "name": "DUF627_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006867": {"description": "Domain of unknown function DUF632", "go_ids": [], "go_terms": [], "name": "DUF632", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006868": {"description": "Domain of unknown function DUF630", "go_ids": [], "go_terms": [], "name": "DUF630", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006869": {"description": "Domain of unknown function DUF547", "go_ids": [], "go_terms": [], "name": "DUF547", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006870": {"description": "Rhabdovirus matrix protein M", "go_ids": ["GO:0016032", "GO:0019031"], "go_terms": ["GO:0016032:viral process:P", "GO:0019031:viral envelope:C"], "name": "Rhabdo_M", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006871": {"description": "ssDNA-binding protein, baculovirus", "go_ids": [], "go_terms": [], "name": "ssDNA-bd_baculovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006872": {"description": "Late protein H7, poxvirus", "go_ids": [], "go_terms": [], "name": "Poxvirus_H7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006873": {"description": "Protein of unknown function DUF620", "go_ids": [], "go_terms": [], "name": "DUF620", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006874": {"description": "Protein of unknown function DUF621", "go_ids": [], "go_terms": [], "name": "DUF621", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006875": {"description": "Sarcoglycan complex subunit protein", "go_ids": ["GO:0016012", "GO:0016020"], "go_terms": ["GO:0016012:sarcoglycan complex:C", "GO:0016020:membrane:C"], "name": "Sarcoglycan", "pathway_ids": ["R-HSA-9913351", "R-CFA-9913351", "R-MMU-9913351", "R-BTA-9913351"], "pathways": ["R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-CFA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-BTA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Family"}, "IPR006876": {"description": "LMBR1-like membrane protein", "go_ids": [], "go_terms": [], "name": "LMBR1-like_membr_prot", "pathway_ids": ["R-XTR-9758890", "R-XTR-9758881", "R-DRE-9758881", "R-GGA-9758881", "R-DDI-9758881", "R-MMU-9758890", "R-GGA-9758890", "R-DRE-9758890", "R-HSA-9758881", "R-MMU-9758881", "R-HSA-9758890", "R-DDI-9758890", "R-HSA-5683329"], "pathways": ["R-XTR-9758890:r:Transport of RCbl within the body", "R-XTR-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DRE-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-GGA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DDI-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-MMU-9758890:r:Transport of RCbl within the body", "R-GGA-9758890:r:Transport of RCbl within the body", "R-DRE-9758890:r:Transport of RCbl within the body", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-MMU-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-9758890:r:Transport of RCbl within the body", "R-DDI-9758890:r:Transport of RCbl within the body", "R-HSA-5683329:r:Defective ABCD4 causes MAHCJ"], "type": "Family"}, "IPR006878": {"description": "BRRF1, herpesviridae", "go_ids": [], "go_terms": [], "name": "Herpes_BBRF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006879": {"description": "Carbohydrate deacetylase YdjC-like", "go_ids": [], "go_terms": [], "name": "YdjC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006880": {"description": "INO80 complex subunit B-like conserved region", "go_ids": ["GO:0031011"], "go_terms": ["GO:0031011:Ino80 complex:C"], "name": "INO80B_C", "pathway_ids": ["R-HSA-5689603", "R-MMU-5696394", "R-MMU-5689603", "R-HSA-5696394"], "pathways": ["R-HSA-5689603:r:UCH proteinases", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Domain"}, "IPR006881": {"description": "Plasmid encoded RepA protein", "go_ids": [], "go_terms": [], "name": "RepA_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006882": {"description": "Herpesvirus Orf11", "go_ids": [], "go_terms": [], "name": "Herpes_Orf11", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR006883": {"description": "Per os infectivity factor 4", "go_ids": [], "go_terms": [], "name": "AcMNPV_PIF-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006884": {"description": "Fzo/mitofusin HR2 domain", "go_ids": ["GO:0003924", "GO:0005741", "GO:0008053", "GO:0016020"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005741:mitochondrial outer membrane:C", "GO:0008053:mitochondrial fusion:P", "GO:0016020:membrane:C"], "name": "Fzo/mitofusin_HR2", "pathway_ids": ["R-CEL-983231", "R-MMU-983231", "R-DME-5205685", "R-CEL-9013419", "R-RNO-5205685", "R-RNO-983231", "R-DME-983231", "R-DME-9013419", "R-HSA-983231", "R-HSA-5205685", "R-RNO-9013419", "R-HSA-9013419", "R-CEL-5205685", "R-MMU-5205685", "R-MMU-9013419"], "pathways": ["R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-9013419:r:RHOT2 GTPase cycle"], "type": "Domain"}, "IPR006885": {"description": "NADH dehydrogenase ubiquinone Fe-S protein 4 mitochondrial-like", "go_ids": ["GO:0022900"], "go_terms": ["GO:0022900:electron transport chain:P"], "name": "NADH_UbQ_FeS_4_mit-like", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-MMU-611105", "R-RNO-6799198", "R-BTA-6799198", "R-DME-611105", "R-BTA-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-6799198:r:Complex I biogenesis", "R-BTA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR006886": {"description": "DNA-directed RNA polymerase III subunit Rpc5", "go_ids": ["GO:0005634", "GO:0006351"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006351:DNA-templated transcription:P"], "name": "RNA_pol_III_Rpc5", "pathway_ids": ["R-HSA-76071", "R-HSA-76066", "R-HSA-73980", "R-HSA-76061", "R-MMU-76061", "R-HSA-1834949", "R-MMU-76071", "R-HSA-73780", "R-MMU-76066", "R-HSA-749476"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation"], "type": "Family"}, "IPR006887": {"description": "Serine/threonine-protein phosphatase 4 regulatory subunit 3-like, central domain", "go_ids": [], "go_terms": [], "name": "P4R3-like_central_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006888": {"description": "XLR/SYCP3/FAM9 domain", "go_ids": [], "go_terms": [], "name": "XLR/SYCP3/FAM9_dom", "pathway_ids": ["R-HSA-1221632"], "pathways": ["R-HSA-1221632:r:Meiotic synapsis"], "type": "Domain"}, "IPR006889": {"description": "Nonstructural protein NSM", "go_ids": [], "go_terms": [], "name": "Bunya_NSM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006890": {"description": "Sulphydryl oxidase, FAD-linked, ERV1/ALR-type", "go_ids": ["GO:0016972"], "go_terms": ["GO:0016972:thiol oxidase activity:F"], "name": "Sulphydryl_Oase_FAD-link_ERV1", "pathway_ids": ["PWY-7533"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis"], "type": "Family"}, "IPR006891": {"description": "Type III secretion protein EspF", "go_ids": [], "go_terms": [], "name": "T3SS_EspF", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR006892": {"description": "Geminivirus AC4/5, conserved domain 1", "go_ids": [], "go_terms": [], "name": "Gemini_AC4_5_cons_dom_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006893": {"description": "Citrus tristeza virus P23 protein", "go_ids": [], "go_terms": [], "name": "CTV_P23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006894": {"description": "HupH hydrogenase expression protein, C-terminal", "go_ids": [], "go_terms": [], "name": "HupH_Hydgase_express_prot_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006895": {"description": "Zinc finger, Sec23/Sec24-type", "go_ids": ["GO:0006886", "GO:0006888", "GO:0008270", "GO:0030127"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P", "GO:0008270:zinc ion binding:F", "GO:0030127:COPII vesicle coat:C"], "name": "Znf_Sec23_Sec24", "pathway_ids": ["R-HSA-1655829", "R-MMU-204005", "R-DDI-983170", "R-HSA-2132295", "R-XTR-204005", "R-DDI-204005", "R-HSA-9705671", "R-DDI-5694530", "R-MMU-5694530", "R-DRE-204005", "R-SCE-204005", "R-SPO-204005", "R-XTR-5694530", "R-SPO-5694530", "R-DRE-5694530", "R-DRE-983170", "R-HSA-5694530", "R-BTA-983170", "R-HSA-204005", "R-HSA-983170", "R-DRE-2132295", "R-SCE-5694530", "R-BTA-5694530", "R-MMU-2132295", "R-MMU-983170", "R-BTA-204005", "R-BTA-2132295", "R-SPO-983170", "R-SCE-983170"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-2132295:r:MHC class II antigen presentation", "R-XTR-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-5694530:r:Cargo concentration in the ER", "R-MMU-5694530:r:Cargo concentration in the ER", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-XTR-5694530:r:Cargo concentration in the ER", "R-SPO-5694530:r:Cargo concentration in the ER", "R-DRE-5694530:r:Cargo concentration in the ER", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-2132295:r:MHC class II antigen presentation", "R-SCE-5694530:r:Cargo concentration in the ER", "R-BTA-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "type": "Domain"}, "IPR006896": {"description": "Sec23/Sec24, trunk domain", "go_ids": ["GO:0006886", "GO:0006888", "GO:0030127"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P", "GO:0030127:COPII vesicle coat:C"], "name": "Sec23/24_trunk_dom", "pathway_ids": ["R-HSA-1655829", "R-MMU-204005", "R-DDI-983170", "R-HSA-2132295", "R-XTR-204005", "R-DDI-204005", "R-HSA-9705671", "R-DDI-5694530", "R-MMU-5694530", "R-DRE-204005", "R-SCE-204005", "R-SPO-204005", "R-XTR-5694530", "R-SPO-5694530", "R-DRE-5694530", "R-DRE-983170", "R-HSA-5694530", "R-BTA-983170", "R-HSA-204005", "R-HSA-983170", "R-DRE-2132295", "R-SCE-5694530", "R-BTA-5694530", "R-MMU-2132295", "R-MMU-983170", "R-BTA-204005", "R-BTA-2132295", "R-SPO-983170", "R-SCE-983170"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-2132295:r:MHC class II antigen presentation", "R-XTR-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-5694530:r:Cargo concentration in the ER", "R-MMU-5694530:r:Cargo concentration in the ER", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-XTR-5694530:r:Cargo concentration in the ER", "R-SPO-5694530:r:Cargo concentration in the ER", "R-DRE-5694530:r:Cargo concentration in the ER", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-2132295:r:MHC class II antigen presentation", "R-SCE-5694530:r:Cargo concentration in the ER", "R-BTA-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "type": "Domain"}, "IPR006897": {"description": "Hepatocyte nuclear factor 1, beta isoform, C-terminal", "go_ids": ["GO:0005634", "GO:0045893"], "go_terms": ["GO:0005634:nucleus:C", "GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "HNF1b_C", "pathway_ids": ["R-HSA-9937080", "R-HSA-9925563", "R-HSA-9831926", "R-HSA-210745", "R-HSA-9925561", "R-HSA-210744", "R-HSA-210747"], "pathways": ["R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-9831926:r:Nephron development", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-210747:r:Regulation of gene expression in early pancreatic precursor cells"], "type": "Domain"}, "IPR006898": {"description": "Hepatocyte nuclear 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Lineage of Pancreatic Acinar Cells", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-210747:r:Regulation of gene expression in early pancreatic precursor cells"], "type": "Domain"}, "IPR006900": {"description": "Sec23/Sec24, helical domain", "go_ids": ["GO:0006886", "GO:0006888", "GO:0030127"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P", "GO:0030127:COPII vesicle coat:C"], "name": "Sec23/24_helical_dom", "pathway_ids": ["R-HSA-1655829", "R-MMU-204005", "R-DDI-983170", "R-HSA-2132295", "R-XTR-204005", "R-DDI-204005", "R-HSA-9705671", "R-DDI-5694530", "R-MMU-5694530", "R-DRE-204005", "R-SCE-204005", "R-SPO-204005", "R-XTR-5694530", "R-SPO-5694530", "R-DRE-5694530", "R-DRE-983170", "R-HSA-5694530", "R-BTA-983170", "R-HSA-204005", "R-HSA-983170", "R-DRE-2132295", "R-SCE-5694530", "R-BTA-5694530", "R-MMU-2132295", "R-MMU-983170", "R-BTA-204005", "R-BTA-2132295", "R-SPO-983170", "R-SCE-983170"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-2132295:r:MHC class II antigen presentation", "R-XTR-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-5694530:r:Cargo concentration in the ER", "R-MMU-5694530:r:Cargo concentration in the ER", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-XTR-5694530:r:Cargo concentration in the ER", "R-SPO-5694530:r:Cargo concentration in the ER", "R-DRE-5694530:r:Cargo concentration in the ER", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-2132295:r:MHC class II antigen presentation", "R-SCE-5694530:r:Cargo concentration in the ER", "R-BTA-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "type": "Domain"}, "IPR006901": {"description": "tRNA methyltransferase TrmK", "go_ids": ["GO:0160105"], "go_terms": ["GO:0160105:tRNA (adenine(22)-N1)-methyltransferase activity:F"], "name": "TrmK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006902": {"description": "Long distance movement protein, Umbravirus", "go_ids": [], "go_terms": [], "name": "Umbravirus_LDM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006904": {"description": "Protein of unknown function DUF716", "go_ids": [], "go_terms": [], "name": "DUF716", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006905": {"description": "Flavin-dependent halogenase", "go_ids": ["GO:0004497"], "go_terms": ["GO:0004497:monooxygenase activity:F"], "name": "Flavin_halogenase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006906": {"description": "Timeless, N-terminal", "go_ids": [], "go_terms": [], "name": "Timeless_N", "pathway_ids": ["R-DME-432620", "R-DME-538898", "R-HSA-5693607", "R-DME-432553", "R-DME-432395", "R-RNO-5693607", "R-DME-432490", "R-DME-432501", "R-MMU-5693607"], "pathways": ["R-DME-432620:r:Dephosphorylation of PER", "R-DME-538898:r:Dephosphorylation of TIM", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-432395:r:Degradation of TIM", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DME-432490:r:Nuclear import of PER and TIM", "R-DME-432501:r:Transcription repression by PER and activation by PDP1", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Domain"}, "IPR006907": {"description": "Disks large homolog 5, N-terminal", "go_ids": [], "go_terms": [], "name": "DLG5_N", "pathway_ids": ["R-HSA-9013420", "R-MMU-9013420", "R-HSA-9696270", "R-MMU-9013424", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9013424", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-HSA-9013420:r:RHOU GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR006908": {"description": "Herpesvirus UL49 tegument protein", "go_ids": [], "go_terms": [], "name": "Herpes_UL49", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006909": {"description": "Rad21/Rec8-like protein, C-terminal, eukaryotic", "go_ids": [], "go_terms": [], "name": "Rad21/Rec8_C_eu", "pathway_ids": ["R-HSA-2468052", "R-SCE-3108214", "R-SPO-2500257", "R-SCE-2468052", "R-MMU-2500257", "R-SPO-3108214", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-3108214", "R-SPO-2470946", "R-BTA-2468052", "R-MMU-2467813", "R-HSA-2470946", "R-HSA-1221632", "R-SCE-2500257", "R-BTA-3108214", "R-BTA-2467813", "R-BTA-2500257", "R-MMU-2470946", "R-MMU-3108214", "R-MMU-2468052", "R-HSA-9018519", "R-BTA-2470946"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-BTA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-1221632:r:Meiotic synapsis", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-BTA-2470946:r:Cohesin Loading onto Chromatin"], "type": "Domain"}, "IPR006910": {"description": "Rad21/Rec8-like protein, N-terminal", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Rad21_Rec8_N", "pathway_ids": ["R-HSA-2468052", "R-SCE-3108214", "R-SPO-2500257", "R-SCE-2468052", "R-MMU-2500257", "R-SPO-3108214", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-3108214", "R-SPO-2470946", "R-BTA-2468052", "R-MMU-2467813", "R-HSA-2470946", "R-HSA-1221632", "R-SCE-2500257", "R-BTA-3108214", "R-BTA-2467813", "R-BTA-2500257", "R-MMU-2470946", "R-MMU-3108214", "R-MMU-2468052", "R-HSA-9018519", "R-BTA-2470946"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-BTA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-1221632:r:Meiotic synapsis", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-BTA-2470946:r:Cohesin Loading onto Chromatin"], "type": "Domain"}, "IPR006911": {"description": "Armadillo repeat-containing domain", "go_ids": [], "go_terms": [], "name": "ARM-rpt_dom", "pathway_ids": ["R-RNO-9013404", "R-MMU-9013404", "R-HSA-9013404"], "pathways": ["R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle"], "type": "Domain"}, "IPR006912": {"description": "Harbinger transposase-derived protein", "go_ids": [], "go_terms": [], "name": "Harbinger_derived_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006913": {"description": "CENP-V/GFA domain", "go_ids": ["GO:0016846"], "go_terms": ["GO:0016846:carbon-sulfur lyase activity:F"], "name": "CENP-V/GFA", "pathway_ids": ["PWY-1801"], "pathways": ["PWY-1801:t:formaldehyde oxidation II (glutathione-dependent)"], "type": "Domain"}, "IPR006914": {"description": "VENN motif-containing domain", "go_ids": [], "go_terms": [], "name": "VENN_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006915": {"description": "Domain of unknown function DUF637, haemagglutinin putative", "go_ids": [], "go_terms": [], "name": "DUF637_hemagglutn_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006916": {"description": "POPDC1-3", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "POPDC1-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006917": {"description": "SOUL heme-binding protein", "go_ids": [], "go_terms": [], "name": "SOUL_heme-bd", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-HSA-418594", "R-MMU-444473", "R-XTR-444473", "R-MMU-418594", "R-HSA-444473", "R-XTR-418594"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-XTR-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-MMU-418594:r:G alpha (i) signalling events", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-XTR-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR006918": {"description": "COBRA", "go_ids": ["GO:0016020", "GO:0010215"], "go_terms": ["GO:0016020:membrane:C", "GO:0010215:cellulose microfibril organization:P"], "name": "COBRA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006920": {"description": "Poxvirus A9", "go_ids": [], "go_terms": [], "name": "Poxvirus_A9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006921": {"description": "Interferon-related developmental regulator, C-terminal", "go_ids": [], "go_terms": [], "name": "Interferon-rel_develop_reg_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006923": {"description": "Baculoviridae late expression factor 5, N-terminal", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Baculo_LEF5_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006924": {"description": "Small ribosomal subunit protein cS23-like", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_cS23-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006925": {"description": "Vps16, C-terminal", "go_ids": ["GO:0005737", "GO:0006886"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006886:intracellular protein transport:P"], "name": "Vps16_C", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR006926": {"description": "Vps16, N-terminal", "go_ids": ["GO:0005737", "GO:0006886"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006886:intracellular protein transport:P"], "name": "Vps16_N", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR006927": {"description": "Protein of unknown function DUF639", "go_ids": [], "go_terms": [], "name": "DUF639", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006928": {"description": "Herpesvirus large tegument protein, USP domain", "go_ids": [], "go_terms": [], "name": "Herpes_teg_USP", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Domain"}, "IPR006930": {"description": "Herpesvirus pp38 phosphoprotein", "go_ids": [], "go_terms": [], "name": "Herpes_pp38", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006931": {"description": "Calcipressin", "go_ids": ["GO:0019722"], "go_terms": ["GO:0019722:calcium-mediated signaling:P"], "name": "Calcipressin", "pathway_ids": ["R-HSA-9692916"], "pathways": ["R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Family"}, "IPR006932": {"description": "Holliday junction resolvase, A22", "go_ids": ["GO:0000287", "GO:0000400", "GO:0006281", "GO:0006310", "GO:0016788"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0000400:four-way junction DNA binding:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "HJ-resolvase_A22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006933": {"description": "HAP1, N-terminal", "go_ids": [], "go_terms": [], "name": "HAP1_N", "pathway_ids": ["R-HSA-9013425", "R-HSA-6802952", "R-DME-9013419", "R-MMU-9013425", "R-RNO-9013419", "R-DME-9013425", "R-HSA-9013419", "R-MMU-9013419"], "pathways": ["R-HSA-9013425:r:RHOT1 GTPase cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-MMU-9013419:r:RHOT2 GTPase cycle"], "type": "Domain"}, "IPR006934": {"description": "Baculovirus ODV-E66, C-terminal domain", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "ODV-E66_C_baculovirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006935": {"description": "Helicase/UvrB, N-terminal", "go_ids": ["GO:0003677", "GO:0005524", "GO:0016787"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F", "GO:0016787:hydrolase activity:F"], "name": "Helicase/UvrB_N", "pathway_ids": ["R-RNO-6781823", "R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-HSA-5689880", "R-RNO-73779", "R-HSA-427413", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-SPO-975957", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-RNO-73776", "R-DRE-75955", "R-MMU-5689880", "R-SPO-76042", "R-HSA-73776", "R-DME-72086", "R-BTA-77075", "R-DDI-674695", "R-SPO-6796648", "R-DME-75953", "R-DME-6782135", "R-BTA-73863", "R-BTA-75955", "R-DRE-6782210", "R-BTA-75953", "R-BTA-6782135", "R-RNO-5696395", "R-HSA-167161", "R-DME-112382", "R-HSA-5696395", "R-DDI-77075", "R-HSA-167160", "R-DDI-113418", "R-SPO-73779", "R-MMU-73772", "R-MMU-72086", "R-BTA-6782210", "R-BTA-73776", "R-SPO-73776", "R-BTA-73772", "R-SCE-73776", "R-HSA-9833109", "R-DDI-5696395", "R-HSA-6781827", "R-HSA-9705671", "R-HSA-168928", "R-HSA-933542", "R-DRE-5696400", "R-DME-73779", "R-DME-77075", "R-DME-73776", "R-MMU-6781823", "R-BTA-6781823", "R-DDI-73772", "R-DDI-6796648", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696400", "R-HSA-167172", "R-DRE-6781823", "R-MMU-5696400", "R-BTA-73779", "R-MMU-975956", "R-SCE-73779", "R-DME-113418", "R-RNO-113418", "R-MMU-6796648", "R-RNO-6796648", "R-DRE-73772", "R-RNO-75955", "R-MMU-975957", "R-SCE-6781823", "R-DME-5696395", "R-BTA-674695", "R-DRE-73776", "R-MMU-426486", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-DRE-6782135", "R-MMU-77075", "R-HSA-75955", "R-DME-5696400", "R-SPO-6782210", "R-HSA-975957", "R-HSA-933541", "R-HSA-933543", "R-RNO-5696400", "R-HSA-5696400", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-SCE-73772", "R-DME-975957", "R-HSA-112382", "R-HSA-73779", "R-RNO-674695", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-DRE-73779", "R-HSA-9920588", "R-BTA-76042", "R-HSA-5689896", "R-RNO-73863", "R-DRE-75953", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-975956", "R-SPO-5696395", "R-HSA-167246", "R-MMU-5696395", "R-DRE-6796648", "R-DRE-113418", "R-CEL-203927", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-RNO-6782210", "R-SPO-113418", "R-SPO-975956", "R-DDI-73779", "R-DME-674695", "R-BTA-72086", "R-RNO-76042", "R-DDI-6781823", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-SCE-76042", "R-MMU-203927", "R-HSA-167200", "R-RNO-112382", "R-SCE-674695", "R-MMU-6782210", "R-RNO-75953", "R-SCE-6782135", "R-DDI-6782135", "R-MMU-73762", "R-MMU-6782135", "R-BTA-113418", "R-DME-6796648", "R-HSA-72086", "R-HSA-936440", "R-HSA-9909505", "R-HSA-167162", "R-DRE-5696395", "R-DRE-73863", "R-DRE-77075", "R-HSA-918233", "R-GGA-353303", "R-HSA-167152", "R-HSA-113418", "R-BTA-5696395", "R-SCE-6782210", "R-BTA-6796648", "R-SCE-6796648", "R-CEL-426486", "R-BTA-73762", "R-RNO-72086", "R-DRE-975956", "R-SPO-77075", "R-RNO-73772", "R-DRE-76042", "R-DME-975956", "R-SCE-113418", "R-SCE-72086", "R-RNO-6782135", "R-MMU-73863", "R-DRE-72086", "R-HSA-6782135", "R-DRE-975957", "R-HSA-73762", "R-DRE-674695", "R-SPO-5696400", "R-SCE-77075", "R-HSA-9692916", "R-DDI-75953", "R-SPO-6782135", "R-DME-73772"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72086:r:mRNA Capping", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-6782135:r:Dual incision in TC-NER", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-6782135:r:Dual incision in TC-NER", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72086:r:mRNA Capping", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-72086:r:mRNA Capping", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-73772:r:RNA Polymerase I Promoter Escape"], "type": "Domain"}, "IPR006936": {"description": "ALOG domain", "go_ids": [], "go_terms": [], "name": "ALOG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006938": {"description": "Protein of unknown function DUF624", "go_ids": [], "go_terms": [], "name": "DUF624", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006939": {"description": "SNF5/SMARCB1/INI1", "go_ids": ["GO:0000228", "GO:0006338"], "go_terms": ["GO:0000228:nuclear chromosome:C", "GO:0006338:chromatin remodeling:P"], "name": "SNF5", "pathway_ids": ["R-GGA-8939243", "R-GGA-9933939", "R-MMU-9933946", "R-MMU-9934037", "R-XTR-3214858", "R-MMU-9933937", "R-HSA-9933939", "R-GGA-3214858", "R-XTR-8939243", "R-DRE-8939243", "R-BTA-9933946", "R-HSA-3214858", "R-HSA-9824585", "R-BTA-9933937", "R-HSA-9934037", "R-XTR-9933937", "R-BTA-9934037", "R-BTA-3214858", "R-XTR-9934037", "R-MMU-9933939", "R-MMU-3214858", "R-HSA-8939243", "R-MMU-8939243", "R-HSA-9845323", "R-HSA-9933937", "R-BTA-8939243", "R-BTA-9933939", "R-GGA-9933937", "R-HSA-9933946", "R-GGA-9934037", "R-DRE-3214858", "R-GGA-9933946"], "pathways": ["R-GGA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-GGA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-XTR-3214858:r:RMTs methylate histone arginines", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-GGA-3214858:r:RMTs methylate histone arginines", "R-XTR-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-XTR-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-XTR-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-GGA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-GGA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-GGA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex"], "type": "Family"}, "IPR006940": {"description": "Securin sister-chromatid separation inhibitor", "go_ids": ["GO:0005634", "GO:0005737", "GO:0051276"], "go_terms": ["GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C", "GO:0051276:chromosome organization:P"], "name": "Securin_separation_inhibitor", "pathway_ids": ["R-HSA-174178", "R-HSA-2467813", "R-RNO-174154", "R-MMU-174154", "R-MMU-2467813", "R-RNO-174178", "R-RNO-2467813", "R-MMU-174178", "R-HSA-174154"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin"], "type": "Family"}, "IPR006941": {"description": "Ribonuclease CAF1", "go_ids": [], "go_terms": [], "name": "RNase_CAF1", "pathway_ids": ["R-MMU-6804115", "R-GGA-6804115", "R-DRE-6804115", "R-BTA-6804115", "R-GGA-429947", "R-HSA-380994", "R-HSA-6804115", "R-MMU-429947", "R-BTA-429947", "R-DRE-450604", "R-HSA-429947", "R-MMU-450604", "R-HSA-450604", "R-HSA-9820841"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-GGA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-GGA-429947:r:Deadenylation of mRNA", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-BTA-429947:r:Deadenylation of mRNA", "R-DRE-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Family"}, "IPR006942": {"description": "TH1 protein", "go_ids": ["GO:0005634", "GO:0045892"], "go_terms": ["GO:0005634:nucleus:C", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "TH1", "pathway_ids": ["R-DME-113418", "R-SSC-674695", "R-SSC-112382", "R-MMU-6796648", "R-SSC-6796648", "R-DME-674695", "R-HSA-167238", "R-HSA-167243", "R-MMU-113418", "R-DME-6796648", "R-HSA-167242", "R-DME-75955", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-SSC-113418", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-75955", "R-HSA-167152", "R-HSA-113418", "R-HSA-674695", "R-HSA-112382", "R-SSC-75955"], "pathways": ["R-DME-113418:r:Formation of the Early Elongation Complex", "R-SSC-674695:r:RNA Polymerase II Pre-transcription Events", "R-SSC-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SSC-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SSC-113418:r:Formation of the Early Elongation Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-SSC-75955:r:RNA Polymerase II Transcription Elongation"], "type": "Family"}, "IPR006943": {"description": "Domain of unknown function DUF641, plant", "go_ids": [], "go_terms": [], "name": "DUF641_pln", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006944": {"description": "Bacteriophage/Gene transfer agent portal protein", "go_ids": [], "go_terms": [], "name": "Phage/GTA_portal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006946": {"description": "DUF642 L-galactono-1,4-lactone-responsive gene 2-like domain", "go_ids": [], "go_terms": [], "name": "DGR2-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006947": {"description": "Alliinase, EGF-like domain", "go_ids": ["GO:0016846"], "go_terms": ["GO:0016846:carbon-sulfur lyase activity:F"], "name": "EGF_alliinase", "pathway_ids": ["PWY-5706", "PWY-5708", "PWY-6900", "PWY-7614", "PWY-5707", "PWY-6539"], "pathways": ["PWY-5706:t:alliin metabolism", "PWY-5708:t:ethiin metabolism", "PWY-6900:t:(Z)-butanethial-S-oxide biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-5707:t:propanethial S-oxide biosynthesis", "PWY-6539:t:(Z)-phenylmethanethial S-oxide biosynthesis"], "type": "Domain"}, "IPR006948": {"description": "Alliinase, C-terminal", "go_ids": ["GO:0016846"], "go_terms": ["GO:0016846:carbon-sulfur lyase activity:F"], "name": "Alliinase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006949": {"description": "Baseplate protein J-like, barrel domain", "go_ids": [], "go_terms": [], "name": "Barrel_Baseplate_J-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006950": {"description": "Non-structural protein 6, Rotavirus", "go_ids": [], "go_terms": [], "name": "Rotavirus_NSP6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006951": {"description": "Protein of unknown function DUF643", "go_ids": [], "go_terms": [], "name": "DUF643", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006952": {"description": "Retinal cGMP phosphodiesterase, gamma subunit", "go_ids": ["GO:0004114", "GO:0007601", "GO:0030553"], "go_terms": ["GO:0004114:3',5'-cyclic-nucleotide phosphodiesterase activity:F", "GO:0007601:visual perception:P", "GO:0030553:cGMP binding:F"], "name": "PDE6_gamma", "pathway_ids": ["R-BTA-2485179", "R-BTA-4086398", "R-HSA-2514859", "R-MMU-2514859", "R-MMU-4086398", "R-HSA-2485179", "R-MMU-2485179", "R-BTA-2514859", "R-HSA-4086398", "R-CFA-2485179", "R-CFA-4086398"], "pathways": ["R-BTA-2485179:r:Activation of the phototransduction cascade", "R-BTA-4086398:r:Ca2+ pathway", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-4086398:r:Ca2+ pathway", "R-CFA-2485179:r:Activation of the phototransduction cascade", "R-CFA-4086398:r:Ca2+ pathway"], "type": "Family"}, "IPR006953": {"description": "Vesicle tethering protein Uso1/P115-like, head domain", "go_ids": ["GO:0000139", "GO:0005737", "GO:0006886", "GO:0048280"], "go_terms": ["GO:0000139:Golgi membrane:C", "GO:0005737:cytoplasm:C", "GO:0006886:intracellular protein transport:P", "GO:0048280:vesicle fusion with Golgi apparatus:P"], "name": "Vesicle_Uso1_P115_head", "pathway_ids": ["R-HSA-204005", "R-SPO-6807878", "R-BTA-6807878", "R-MMU-204005", "R-SCE-6807878", "R-RNO-6807878", "R-DME-204005", "R-HSA-6807878", "R-BTA-204005", "R-MMU-6807878", "R-DME-6807878", "R-RNO-204005", "R-HSA-162658"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization"], "type": "Domain"}, "IPR006954": {"description": "Moulting cycle mlt-10-like", "go_ids": [], "go_terms": [], "name": "Mlt-10-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006955": {"description": "Uso1/p115-like vesicle tethering protein, C-terminal", "go_ids": ["GO:0006886", "GO:0016192"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P"], "name": "Uso1_p115_C", "pathway_ids": ["R-HSA-204005", "R-BTA-6807878", "R-MMU-204005", "R-SCE-6807878", "R-RNO-6807878", "R-DME-204005", "R-HSA-6807878", "R-BTA-204005", "R-MMU-6807878", "R-DME-6807878", "R-RNO-204005", "R-HSA-162658"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization"], "type": "Domain"}, "IPR006956": {"description": "Poxvirus L5", "go_ids": [], "go_terms": [], "name": "Poxvirus_L5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006957": {"description": "Ethylene insensitive 3", "go_ids": ["GO:0005634", "GO:0003700"], "go_terms": ["GO:0005634:nucleus:C", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "EIN3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006958": {"description": "Mak16 protein", "go_ids": [], "go_terms": [], "name": "Mak16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006959": {"description": "Protein of unknown function DUF645", "go_ids": [], "go_terms": [], "name": "DUF645", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006960": {"description": "Major non-capsid protein, tenuivirus", "go_ids": [], "go_terms": [], "name": "Major_non-capsid_tenuivirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006961": {"description": "Harpin, HrpN/Z", "go_ids": [], "go_terms": [], "name": "HrpN/Z", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006962": {"description": "P48 protein, Baculovirus", "go_ids": [], "go_terms": [], "name": "P48_Baculovir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006963": {"description": "Molybdopterin oxidoreductase, 4Fe-4S domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Mopterin_OxRdtase_4Fe-4S_dom", "pathway_ids": ["R-DDI-9837999", "R-RNO-611105", "R-HSA-611105", "R-MMU-9837999", "R-MMU-6799198", "R-BTA-9837999", "R-HSA-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DME-9837999", "R-MMU-611105", "R-HSA-9837999", "R-RNO-9837999", "R-BTA-6799198", "R-DDI-6799198", "R-DME-611105", "R-BTA-611105"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6799198:r:Complex I biogenesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR006964": {"description": "NUDE domain", "go_ids": [], "go_terms": [], "name": "NUDE_dom", "pathway_ids": ["R-GGA-380284", "R-MMU-2467813", "R-GGA-2565942", "R-HSA-380284", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-XTR-141444", "R-HSA-380320", "R-GGA-9648025", "R-RNO-380284", "R-GGA-5663220", "R-DRE-5663220", "R-MMU-5620912", "R-MMU-141444", "R-MMU-380259", "R-MMU-380270", "R-HSA-141444", "R-HSA-9648025", "R-GGA-5620912", "R-RNO-5663220", "R-XTR-380320", "R-XTR-380259", "R-GGA-141444", "R-MMU-8854518", "R-RNO-2467813", "R-GGA-8854518", "R-RNO-380270", "R-MMU-5663220", "R-RNO-141444", "R-HSA-2467813", "R-RNO-2500257", "R-XTR-2467813", "R-XTR-380270", "R-RNO-5620912", "R-MMU-380284", "R-GGA-2500257", "R-HSA-2565942", "R-XTR-5620912", "R-RNO-2565942", "R-HSA-68877", "R-GGA-2467813", "R-MMU-9648025", "R-HSA-5620912", "R-GGA-380259", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-HSA-2500257", "R-RNO-8854518", "R-DRE-2500257", "R-XTR-5663220", "R-XTR-380284", "R-GGA-380320", "R-HSA-380270", "R-XTR-68877", "R-RNO-380259", "R-XTR-2565942", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259", "R-XTR-8854518", "R-XTR-2500257", "R-GGA-380270"], "pathways": ["R-GGA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-GGA-8854518:r:AURKA Activation by TPX2", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-68877:r:Mitotic Prometaphase", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR006965": {"description": "Adenovirus Gp19K", "go_ids": ["GO:0005537", "GO:0052031"], "go_terms": ["GO:0005537:D-mannose binding:F", "GO:0052031:symbiont-mediated perturbation of host defense response:P"], "name": "Adenovirus_Gp19K", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006966": {"description": "Peroxin-3", "go_ids": ["GO:0007031", "GO:0005778"], "go_terms": ["GO:0007031:peroxisome organization:P", "GO:0005778:peroxisomal membrane:C"], "name": "Peroxin-3", "pathway_ids": ["R-DDI-1369062", "R-SCE-9603798", "R-SCE-1369062", "R-SPO-9603798", "R-RNO-9603798", "R-RNO-1369062", "R-DDI-9603798", "R-MMU-1369062", "R-MMU-9603798", "R-HSA-9603798", "R-HSA-1369062"], "pathways": ["R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-1369062:r:ABC transporters in lipid homeostasis", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-1369062:r:ABC transporters in lipid homeostasis"], "type": "Family"}, "IPR006968": {"description": "Root UVB sensitive family", "go_ids": [], "go_terms": [], "name": "RUS_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006969": {"description": "Stigma-specific protein Stig1-like", "go_ids": [], "go_terms": [], "name": "Stig-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006970": {"description": "PT repeat", "go_ids": [], "go_terms": [], "name": "PT", "pathway_ids": ["R-RNO-6798695", "R-MMU-1433557", "R-RNO-2022090", "R-RNO-1592389", "R-MMU-1592389", "R-MMU-3928665", "R-RNO-1474228", "R-BTA-1442490", "R-BTA-1474228", "R-RNO-9009391", "R-BTA-6798695", "R-MMU-9009391", "R-BTA-9009391", "R-RNO-1442490", "R-MMU-2022090", "R-RNO-1433557", "R-BTA-1592389", "R-RNO-3928665", "R-MMU-6798695", "R-BTA-3928665", "R-MMU-1442490", "R-BTA-1433557", "R-MMU-1474228"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-BTA-1442490:r:Collagen degradation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-1442490:r:Collagen degradation", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1442490:r:Collagen degradation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Repeat"}, "IPR006971": {"description": "Poxvirus M2", "go_ids": [], "go_terms": [], "name": "Poxvirus_M2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006972": {"description": "Translocator protein BipB-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BipB-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006973": {"description": "Pre-mRNA-splicing factor Cwf15/Cwc15", "go_ids": ["GO:0000398", "GO:0005681"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P", "GO:0005681:spliceosomal complex:C"], "name": "Cwf_Cwc_15", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-MMU-72163", "R-DME-72163", "R-RNO-72163", "R-XTR-72163", "R-CEL-72163", "R-SPO-72163", "R-HSA-9918481", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR006974": {"description": "Protein of unknown function DUF648", "go_ids": [], "go_terms": [], "name": "DUF648", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006975": {"description": "NifQ", "go_ids": ["GO:0009399", "GO:0030151"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0030151:molybdenum ion binding:F"], "name": "NifQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006976": {"description": "VanZ-LLP1", "go_ids": [], "go_terms": [], "name": "VanZ-LLP1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006977": {"description": "Yip1 domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Yip1_dom", "pathway_ids": ["R-BTA-432722", "R-HSA-432722", "R-XTR-432722", "R-RNO-432722", "R-MMU-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-XTR-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR006978": {"description": "Archaeal Nre, N-terminal", "go_ids": [], "go_terms": [], "name": "Nre_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006979": {"description": "Archaeal Nre, C-terminal", "go_ids": [], "go_terms": [], "name": "Nre_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006980": {"description": "Ammonia monooxygenase/particulate methane monooxygenase, subunit C", "go_ids": [], "go_terms": [], "name": "NH3_CH4_mOase_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006982": {"description": "Glutamate synthase, central-N", "go_ids": ["GO:0015930"], "go_terms": ["GO:0015930:glutamate synthase activity:F"], "name": "Glu_synth_centr_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR006983": {"description": "MbeD/MobD-like", "go_ids": [], "go_terms": [], "name": "MbeD_MobD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006984": {"description": "Fcf1/UTP23", "go_ids": ["GO:0032040"], "go_terms": ["GO:0032040:small-subunit processome:C"], "name": "Fcf1/UTP23", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR006985": {"description": "Receptor activity modifying protein", "go_ids": ["GO:0006886", "GO:0008277", "GO:0016020", "GO:0015026"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0008277:regulation of G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C", "GO:0015026:coreceptor activity:F"], "name": "RAMP", "pathway_ids": ["R-RNO-9856530", "R-MMU-419812", "R-HSA-418555", "R-HSA-9856530", "R-RNO-419812", "R-MMU-9856530", "R-MMU-418555", "R-HSA-419812"], "pathways": ["R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-419812:r:Calcitonin-like ligand receptors", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-419812:r:Calcitonin-like ligand receptors", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-419812:r:Calcitonin-like ligand receptors"], "type": "Family"}, "IPR006986": {"description": "Nab1, C-terminal", "go_ids": ["GO:0006355", "GO:0005634", "GO:0003712"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0005634:nucleus:C", "GO:0003712:transcription coregulator activity:F"], "name": "Nab1_C", "pathway_ids": ["R-HSA-9619665", "R-HSA-9031628"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9031628:r:NGF-stimulated transcription"], "type": "Domain"}, "IPR006988": {"description": "Nab, N-terminal", "go_ids": ["GO:0006355", "GO:0005634", "GO:0003712"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0005634:nucleus:C", "GO:0003712:transcription coregulator activity:F"], "name": "Nab_N", "pathway_ids": ["R-HSA-9619665", "R-DME-9031628", "R-HSA-9031628", "R-CEL-9031628", "R-MMU-9031628"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-9031628:r:NGF-stimulated transcription", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-MMU-9031628:r:NGF-stimulated transcription"], "type": "Domain"}, "IPR006989": {"description": "NAB co-repressor, domain", "go_ids": ["GO:0005634", "GO:0045892"], "go_terms": ["GO:0005634:nucleus:C", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "NAB_co-repressor_dom", "pathway_ids": ["R-HSA-9619665", "R-DME-9031628", "R-HSA-9031628", "R-CEL-9031628", "R-MMU-9031628"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-9031628:r:NGF-stimulated transcription", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-MMU-9031628:r:NGF-stimulated transcription"], "type": "Domain"}, "IPR006990": {"description": "Tweety", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Tweety", "pathway_ids": ["R-CEL-2672351", "R-DRE-2672351", "R-HSA-2672351", "R-RNO-2672351", "R-XTR-2672351", "R-MMU-2672351", "R-DME-2672351"], "pathways": ["R-CEL-2672351:r:Stimuli-sensing channels", "R-DRE-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-RNO-2672351:r:Stimuli-sensing channels", "R-XTR-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DME-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR006993": {"description": "SH3-binding, glutamic acid-rich protein", "go_ids": [], "go_terms": [], "name": "Glut_rich_SH3-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006994": {"description": "TCF25/Rqc1", "go_ids": [], "go_terms": [], "name": "TCF25/Rqc1", "pathway_ids": ["R-SPO-9954709", "R-DDI-9954709", "R-HSA-9954709", "R-SCE-9954709", "R-MMU-9954709", "R-RNO-9954709"], "pathways": ["R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Family"}, "IPR006995": {"description": "ATP synthase, F0 complex, subunit J", "go_ids": ["GO:0045259", "GO:0015078", "GO:0015986"], "go_terms": ["GO:0045259:proton-transporting ATP synthase complex:C", "GO:0015078:proton transmembrane transporter activity:F", "GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_F0_jsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006997": {"description": "Baculovirus Y142 protein", "go_ids": [], "go_terms": [], "name": "Baculo_Y142", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR006998": {"description": "DltD", "go_ids": [], "go_terms": [], "name": "DltD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007000": {"description": "Phospholipase B-like", "go_ids": ["GO:0004620"], "go_terms": ["GO:0004620:glycerophospholipase activity:F"], "name": "PLipase_B-like", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521", "R-BTA-1483115", "R-BTA-1482788", "R-RNO-1483115", "R-DDI-1483115", "R-RNO-1482922", "R-DDI-1482922", "R-DDI-1482839", "R-BTA-1482839", "R-MMU-1482839", "R-MMU-1483115", "R-RNO-1482788", "R-HSA-1482922", "R-MMU-1482922", "R-HSA-1482839", "R-MMU-1482788", "R-BTA-1482922", "R-RNO-1482839", "R-HSA-1483115", "R-DDI-1482788", "R-HSA-1482788"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation", "R-BTA-1483115:r:Hydrolysis of LPC", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-RNO-1483115:r:Hydrolysis of LPC", "R-DDI-1483115:r:Hydrolysis of LPC", "R-RNO-1482922:r:Acyl chain remodelling of PI", "R-DDI-1482922:r:Acyl chain remodelling of PI", "R-DDI-1482839:r:Acyl chain remodelling of PE", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-MMU-1483115:r:Hydrolysis of LPC", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-HSA-1483115:r:Hydrolysis of LPC", "R-DDI-1482788:r:Acyl chain remodelling of PC", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Family"}, "IPR007001": {"description": "Bacterial shufflon protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Shufflon_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007003": {"description": "Protein of unknown function DUF655", "go_ids": [], "go_terms": [], "name": "DUF655", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007004": {"description": "Beet necrotic yellow vein virus, p31", "go_ids": [], "go_terms": [], "name": "BNYVV_p31", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007005": {"description": "XAP5 protein", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "XAP5", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-DME-72163", "R-CEL-72163", "R-DDI-72163", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR007007": {"description": "Ninjurin", "go_ids": ["GO:0007155", "GO:0016020", "GO:0042246"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0016020:membrane:C", "GO:0042246:tissue regeneration:P"], "name": "Ninjurin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007008": {"description": "Poxvirus A6", "go_ids": [], "go_terms": [], "name": "Poxvirus_A6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007009": {"description": "Shq1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Shq1_C", "pathway_ids": ["R-BTA-171319", "R-HSA-171319", "R-CEL-171319", "R-DRE-171319", "R-SPO-171319", "R-DME-171319", "R-SCE-171319", "R-MMU-171319"], "pathways": ["R-BTA-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-CEL-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-DME-171319:r:Telomere Extension By Telomerase", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR007010": {"description": "Poly(A) polymerase, RNA-binding domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "PolA_pol_RNA-bd_dom", "pathway_ids": ["R-MMU-9930044", "R-HSA-9930044", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-77595", "R-BTA-73856", "R-HSA-73856", "R-MMU-73856", "R-DDI-9770562", "R-HSA-72187", "R-SPO-9930044", "R-HSA-77595", "R-SPO-9770562", "R-MMU-72187", "R-BTA-9770562", "R-HSA-9918481", "R-DDI-9930044", "R-BTA-77595"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-9930044:r:Nuclear RNA decay", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR007011": {"description": "Late embryogenesis abundant protein, SMP subgroup domain", "go_ids": [], "go_terms": [], "name": "LEA_SMP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007012": {"description": "Poly(A) polymerase, central domain", "go_ids": ["GO:1990817"], "go_terms": ["GO:1990817:poly(A) RNA polymerase activity:F"], "name": "PolA_pol_cen_dom", "pathway_ids": ["R-MMU-9930044", "R-HSA-9930044", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-77595", "R-BTA-73856", "R-HSA-73856", "R-MMU-73856", "R-DDI-9770562", "R-HSA-72187", "R-SPO-9930044", "R-HSA-77595", "R-SPO-9770562", "R-MMU-72187", "R-BTA-9770562", "R-HSA-9918481", "R-DDI-9930044", "R-BTA-77595"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-9930044:r:Nuclear RNA decay", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR007013": {"description": "DNA polymerase processivity factor, herpesviridae", "go_ids": [], "go_terms": [], "name": "DNA_pol_proc_fac_herpes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007014": {"description": "FUN14", "go_ids": [], "go_terms": [], "name": "FUN14", "pathway_ids": ["R-SPO-8934903", "R-HSA-8934903", "R-MMU-8934903", "R-RNO-8934903", "R-BTA-8934903", "R-CEL-8934903", "R-SCE-8934903", "R-DRE-8934903"], "pathways": ["R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-DRE-8934903:r:Receptor Mediated Mitophagy"], "type": "Family"}, "IPR007015": {"description": "DNA polymerase V/Myb-binding protein 1A", "go_ids": ["GO:0003677", "GO:0006355", "GO:0005730", "GO:0008134"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0005730:nucleolus:C", "GO:0008134:transcription factor binding:F"], "name": "DNA_pol_V/MYBBP1A", "pathway_ids": ["R-HSA-5250924", "R-MMU-5250924", "R-RNO-5250924", "R-DRE-5250924"], "pathways": ["R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression"], "type": "Family"}, "IPR007016": {"description": "O-antigen ligase-related domain", "go_ids": [], "go_terms": [], "name": "O-antigen_ligase-rel_domated", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007018": {"description": "Mediator complex, subunit Med6", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med6", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-BTA-9841922", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR007019": {"description": "Surfeit locus 6", "go_ids": [], "go_terms": [], "name": "SURF6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007020": {"description": "Protein of unknown function DUF658", "go_ids": [], "go_terms": [], "name": "DUF658", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007021": {"description": "Domain of unknown function DUF659", "go_ids": [], "go_terms": [], "name": "DUF659", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007023": {"description": "Ribosomal biogenesis regulatory protein", "go_ids": ["GO:0005634", "GO:0042254", "GO:0005515"], "go_terms": ["GO:0005634:nucleus:C", "GO:0042254:ribosome biogenesis:P", "GO:0005515:protein binding:F"], "name": "Ribosom_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007024": {"description": "BLUF domain", "go_ids": ["GO:0071949", "GO:0009882"], "go_terms": ["GO:0071949:FAD binding:F", "GO:0009882:blue light photoreceptor activity:F"], "name": "BLUF_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007025": {"description": "Late expression factor 8 (LEF-8)", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "LEF-8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007026": {"description": "CC domain", "go_ids": [], "go_terms": [], "name": "CC_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007027": {"description": "Poxvirus F11", "go_ids": [], "go_terms": [], "name": "Poxvirus_F11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007029": {"description": "YHS domain", "go_ids": [], "go_terms": [], "name": "YHS_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007031": {"description": "Poxvirus VLTF3, late transcription factor", "go_ids": ["GO:0046782"], "go_terms": ["GO:0046782:regulation of viral transcription:P"], "name": "Poxvirus_VLTF3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007032": {"description": "Poxvirus A51", "go_ids": [], "go_terms": [], "name": "Poxvirus_A51", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007033": {"description": "RAB6-interacting golgin", "go_ids": [], "go_terms": [], "name": "GORAB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007034": {"description": "Ribosome biogenesis protein BMS1/TSR1, C-terminal", "go_ids": [], "go_terms": [], "name": "BMS1_TSR1_C", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR007035": {"description": "Peptidase M55, D-aminopeptidase", "go_ids": [], "go_terms": [], "name": "Peptidase_M55", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007036": {"description": "AstE/AspA barrel-sandwich hybrid domain", "go_ids": [], "go_terms": [], "name": "Aste_AspA_hybrid_dom", "pathway_ids": ["R-MMU-5423646", "R-XTR-8963693", "R-RNO-5423646", "R-MMU-8963693", "R-HSA-8963693", "R-XTR-5423646", "R-HSA-5423646", "R-RNO-8963693", "R-DRE-5423646", "R-DRE-8963693"], "pathways": ["R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-XTR-8963693:r:Aspartate and asparagine metabolism", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-XTR-5423646:r:Aflatoxin activation and detoxification", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-DRE-5423646:r:Aflatoxin activation and detoxification", "R-DRE-8963693:r:Aspartate and asparagine metabolism"], "type": "Domain"}, "IPR007037": {"description": "SIP-like, Rossmann fold domain", "go_ids": [], "go_terms": [], "name": "SIP_rossman_dom", "pathway_ids": ["R-HSA-1222449", "R-HSA-9638334"], "pathways": ["R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-HSA-9638334:r:Iron assimilation using enterobactin"], "type": "Domain"}, "IPR007038": {"description": "Hydrogenase/Urease accessory protein HupE/UreJ protein", "go_ids": [], "go_terms": [], "name": "HupE_UreJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007039": {"description": "Conjugal transfer TrbC/type IV secretion VirB2", "go_ids": [], "go_terms": [], "name": "TrbC/VirB2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007040": {"description": "Ribosome modulation factor", "go_ids": [], "go_terms": [], "name": "Ribosome_modulation_factor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007041": {"description": "Arginine N-succinyltransferase AstA/AruG", "go_ids": ["GO:0006527", "GO:0008791"], "go_terms": ["GO:0006527:L-arginine catabolic process:P", "GO:0008791:L-arginine N-succinyltransferase activity:F"], "name": "Arg_succinylTrfase_AstA/AruG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007042": {"description": "SERRATE/Ars2 , C-terminal", "go_ids": [], "go_terms": [], "name": "SERRATE/Ars2_C", "pathway_ids": ["R-MMU-9930044", "R-CEL-6807505", "R-HSA-9930044", "R-HSA-6807505", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-DME-72163", "R-SPO-9930044", "R-DME-9930044", "R-MMU-6807505", "R-DRE-6807505", "R-BTA-9930044", "R-DRE-9930044", "R-DRE-72163", "R-SPO-9770562", "R-HSA-72163", "R-DME-9770562", "R-DME-6807505", "R-DRE-9770562", "R-CEL-9770562", "R-BTA-9770562", "R-CEL-9930044", "R-CEL-72163", "R-BTA-6807505", "R-SPO-72163", "R-HSA-9918481", "R-BTA-72163"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9930044:r:Nuclear RNA decay", "R-DME-9930044:r:Nuclear RNA decay", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-9930044:r:Nuclear RNA decay", "R-DRE-9930044:r:Nuclear RNA decay", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR007044": {"description": "Cyclodeaminase/cyclohydrolase", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Cyclodeamin/CycHdrlase", "pathway_ids": ["PWY-5030", "PWY-5497", "R-MMU-70921", "R-RNO-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Domain"}, "IPR007045": {"description": "5-keto 4-deoxyuronate isomerase", "go_ids": ["GO:0045490", "GO:0008697"], "go_terms": ["GO:0045490:pectin catabolic process:P", "GO:0008697:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity:F"], "name": "KduI", "pathway_ids": ["PWY-6507"], "pathways": ["PWY-6507:t:4-deoxy-L-threo-hex-4-enopyranuronate degradation"], "type": "Family"}, "IPR007046": {"description": "RNA polymerase sigma factor 54, core-binding domain", "go_ids": ["GO:0003677", "GO:0006352"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006352:DNA-templated transcription initiation:P"], "name": "RNA_pol_sigma_54_core-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007047": {"description": "Flp/Fap pilin component", "go_ids": [], "go_terms": [], "name": "Flp_Fap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007048": {"description": "IraD/Gp25-like", "go_ids": [], "go_terms": [], "name": "IraD/Gp25-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007049": {"description": "Carbohydrate-selective porin OprB", "go_ids": ["GO:0016020", "GO:0008643", "GO:0015288"], "go_terms": ["GO:0016020:membrane:C", "GO:0008643:carbohydrate transport:P", "GO:0015288:porin activity:F"], "name": "Carb-sel_porin_OprB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007050": {"description": "Bacterioopsin activator-type, HTH domain", "go_ids": [], "go_terms": [], "name": "HTH_bacterioopsin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007051": {"description": "CHORD domain", "go_ids": [], "go_terms": [], "name": "CHORD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007052": {"description": "CS domain", "go_ids": [], "go_terms": [], "name": "CS_dom", "pathway_ids": ["R-RNO-1237044", "R-HSA-5689880", "R-MMU-2467813", "R-DME-3371497", "R-MMU-75876", "R-MMU-68877", "R-DME-2162123", "R-RNO-9018519", "R-MMU-5689880", "R-CEL-8939211", "R-HSA-8939211", "R-MMU-3371511", "R-RNO-8939211", "R-BTA-2500257", "R-HSA-9018519", "R-RNO-8937144", "R-DME-9648025", "R-MMU-8939211", "R-SPO-844456", "R-MMU-141444", "R-RNO-2162123", "R-DME-9018519", "R-SCE-171319", "R-HSA-9660826", "R-RNO-3371511", "R-HSA-141444", "R-DDI-844456", "R-DRE-171319", "R-RNO-844456", "R-RNO-5663220", "R-HSA-9648025", "R-RNO-5689880", "R-MMU-9018519", "R-MMU-171319", "R-BTA-171319", "R-DME-3371568", "R-MMU-3371568", "R-CEL-8937144", "R-RNO-2467813", "R-BTA-9648025", "R-MMU-5663220", "R-RNO-141444", "R-MMU-3371497", "R-HSA-844456", "R-HSA-3371511", "R-HSA-2467813", "R-RNO-2500257", "R-RNO-9696270", "R-RNO-3371497", "R-CEL-3371511", "R-HSA-3371497", "R-BTA-5663220", "R-MMU-8937144", "R-DRE-75876", "R-HSA-1237044", "R-HSA-171319", "R-RNO-3371568", "R-BTA-2467813", "R-XTR-1237044", "R-HSA-68877", "R-SCE-2162123", "R-SPO-2162123", "R-MMU-9648025", "R-DME-8937144", "R-HSA-3371568", "R-HSA-8937144", "R-HSA-2162123", "R-MMU-2500257", "R-MMU-1237044", "R-BTA-9696270", "R-RNO-68877", "R-HSA-2500257", "R-SPO-171319", "R-HSA-9696270", "R-MMU-2162123", "R-SPO-9648025", "R-DDI-9648025", "R-SCE-3371511", "R-HSA-9679191", "R-DME-3371511", "R-MMU-844456", "R-BTA-844456", "R-SCE-8939211", "R-SPO-3371511", "R-CEL-2162123", "R-BTA-75876", "R-RNO-9648025", "R-HSA-5663220", "R-SCE-844456", "R-BTA-1237044", "R-MMU-9696270", "R-DME-8939211", "R-BTA-141444", "R-HSA-75876"], "pathways": ["R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-68877:r:Mitotic Prometaphase", "R-DME-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-8939211:r:ESR-mediated signaling", "R-HSA-8939211:r:ESR-mediated signaling", "R-MMU-3371511:r:HSF1 activation", "R-RNO-8939211:r:ESR-mediated signaling", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-RNO-8937144:r:Aryl hydrocarbon receptor signalling", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-8939211:r:ESR-mediated signaling", "R-SPO-844456:r:The NLRP3 inflammasome", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-3371511:r:HSF1 activation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-844456:r:The NLRP3 inflammasome", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-844456:r:The NLRP3 inflammasome", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-BTA-171319:r:Telomere Extension By Telomerase", "R-DME-3371568:r:Attenuation phase", "R-MMU-3371568:r:Attenuation phase", "R-CEL-8937144:r:Aryl hydrocarbon receptor signalling", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-3371511:r:HSF1 activation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9696270:r:RND2 GTPase cycle", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-CEL-3371511:r:HSF1 activation", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-8937144:r:Aryl hydrocarbon receptor signalling", "R-DRE-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-RNO-3371568:r:Attenuation phase", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-XTR-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-68877:r:Mitotic Prometaphase", "R-SCE-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-SPO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-3371568:r:Attenuation phase", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-BTA-9696270:r:RND2 GTPase cycle", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-SPO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-3371511:r:HSF1 activation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-3371511:r:HSF1 activation", "R-MMU-844456:r:The NLRP3 inflammasome", "R-BTA-844456:r:The NLRP3 inflammasome", "R-SCE-8939211:r:ESR-mediated signaling", "R-SPO-3371511:r:HSF1 activation", "R-CEL-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-SCE-844456:r:The NLRP3 inflammasome", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DME-8939211:r:ESR-mediated signaling", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs"], "type": "Domain"}, "IPR007053": {"description": "LRAT domain", "go_ids": [], "go_terms": [], "name": "LRAT_dom", "pathway_ids": ["R-RNO-1482922", "R-MMU-2453902", "R-RNO-2453902", "R-MMU-1482839", "R-HSA-1482801", "R-MMU-975634", "R-RNO-1482788", "R-RNO-1482839", "R-HSA-1482922", "R-MMU-1482922", "R-DRE-1482839", "R-HSA-1482839", "R-MMU-1482788", "R-HSA-9918442", "R-RNO-975634", "R-MMU-1482801", "R-RNO-1482801", "R-HSA-2453902", "R-HSA-975634", "R-HSA-1482788"], "pathways": ["R-RNO-1482922:r:Acyl chain remodelling of PI", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-1482801:r:Acyl chain 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"R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Domain"}, "IPR007067": {"description": "Tail sheath protein", "go_ids": [], "go_terms": [], "name": "Tail_sheath", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007069": {"description": "Transposase, IS801/IS1294", "go_ids": ["GO:0003677", "GO:0004803", "GO:0006313"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004803:transposase activity:F", "GO:0006313:DNA transposition:P"], "name": "Transposase_32", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007070": {"description": "GPI ethanolamine phosphate transferase 1", "go_ids": ["GO:0005789", "GO:0006506", "GO:0051377"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0006506:GPI anchor biosynthetic process:P", "GO:0051377:mannose-ethanolamine phosphotransferase activity:F"], "name": "GPI_EtnP_transferase_1", "pathway_ids": ["R-HSA-162710", "R-SCE-162710", "R-SPO-162710", "R-MMU-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR007071": {"description": "A-kinase anchoring protein 95 (AKAP95)", "go_ids": ["GO:0003677", "GO:0005634"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C"], "name": "AKAP95", "pathway_ids": ["R-MMU-9772755", "R-HSA-9772755"], "pathways": ["R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Family"}, "IPR007072": {"description": "Rhamnosyl O-methyltransferase", "go_ids": ["GO:0008168", "GO:0008610"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0008610:lipid biosynthetic process:P"], "name": "RNMT_CmcI", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR007073": {"description": "RNA polymerase Rpb1, domain 7", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "RNA_pol_Rpb1_7", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-CEL-72165", "R-MMU-9770562", "R-CEL-72203", "R-DDI-73776", "R-DME-72163", "R-DDI-6782210", "R-SPO-6781823", "R-DME-75955", "R-DDI-72163", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-BTA-9018519", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-DME-72203", "R-DME-72086", "R-DDI-674695", "R-CEL-9770562", "R-CEL-75953", "R-DME-75953", "R-SPO-6796648", "R-CEL-73776", "R-DME-6782135", "R-BTA-72163", "R-BTA-75955", "R-BTA-75953", "R-MMU-72163", "R-BTA-6782135", "R-SPO-9018519", "R-HSA-6803529", "R-HSA-167242", "R-CEL-6782210", "R-HSA-8851708", "R-CEL-674695", "R-HSA-167161", "R-HSA-72163", "R-DME-112382", "R-CEL-112382", "R-CEL-6782135", "R-HSA-9670095", "R-HSA-167160", "R-DDI-77075", "R-DDI-113418", "R-BTA-6782210", "R-MMU-72086", "R-SPO-73779", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-HSA-6781827", "R-HSA-5578749", "R-DME-5578749", "R-DME-73779", "R-DME-77075", "R-BTA-5578749", "R-DME-9770562", "R-DME-73776", "R-BTA-6781823", "R-MMU-6781823", "R-HSA-203927", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-MMU-73776", "R-HSA-72165", "R-DDI-76042", "R-CEL-72163", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-DME-113418", "R-CEL-75955", "R-MMU-6796648", "R-HSA-72203", "R-BTA-72165", "R-HSA-9770562", "R-HSA-167243", "R-SCE-6781823", "R-BTA-674695", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-167290", "R-MMU-77075", "R-MMU-72165", "R-HSA-75955", "R-SPO-6782210", "R-CEL-9018519", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-BTA-6807505", "R-BTA-72203", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-DME-6781823", "R-DME-76042", "R-MMU-113418", "R-BTA-76042", "R-SPO-6807505", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-HSA-9018519", "R-HSA-5601884", "R-SPO-75953", "R-SPO-113418", "R-CEL-6807505", "R-DME-674695", "R-DDI-73779", "R-BTA-72086", "R-DME-9018519", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-CEL-113418", "R-DDI-72086", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-MMU-9018519", "R-CEL-6781823", "R-DME-6807505", "R-DDI-6807505", "R-SPO-9770562", "R-HSA-167200", "R-DME-72165", "R-SCE-674695", "R-BTA-9770562", "R-MMU-6782210", "R-CEL-6796648", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-MMU-6782135", "R-BTA-113418", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-HSA-167152", "R-HSA-113418", "R-BTA-112382", "R-SCE-6782210", "R-BTA-6796648", "R-HSA-9918481", "R-SCE-72203", "R-SCE-6796648", "R-SPO-72203", "R-SPO-77075", "R-SCE-113418", "R-SCE-72086", "R-HSA-6782135", "R-CEL-77075", "R-SCE-77075", "R-DDI-75953", "R-SPO-6782135", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-72086:r:mRNA Capping", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-6782135:r:Dual incision in TC-NER", 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interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA 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Tat", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Domain"}, "IPR007084": {"description": "BRICHOS domain", "go_ids": [], "go_terms": [], "name": "BRICHOS_dom", "pathway_ids": ["R-HSA-5683826", "R-HSA-5688890", "R-RNO-5683826", "R-HSA-5688354", "R-MMU-5683826", "R-HSA-5688849", "R-HSA-977225"], "pathways": ["R-HSA-5683826:r:Surfactant metabolism", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-RNO-5683826:r:Surfactant metabolism", "R-HSA-5688354:r:Defective pro-SFTPC causes SMDP2 and RDS", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-HSA-977225:r:Amyloid fiber formation"], "type": "Domain"}, "IPR007085": {"description": "DNA/pantothenate metabolism flavoprotein, C-terminal", "go_ids": [], "go_terms": [], "name": "DNA/pantothenate-metab_flavo_C", "pathway_ids": ["PWY-7851", "PWY-8342", "R-MMU-196783", "R-SPO-196783", "R-SCE-196783", "R-HSA-196783"], "pathways": ["PWY-7851:t:coenzyme A biosynthesis II (eukaryotic)", "PWY-8342:t:coenzyme A biosynthesis III (archaea)", "R-MMU-196783:r:Coenzyme A biosynthesis", "R-SPO-196783:r:Coenzyme A biosynthesis", "R-SCE-196783:r:Coenzyme A biosynthesis", "R-HSA-196783:r:Coenzyme A biosynthesis"], "type": "Domain"}, "IPR007100": {"description": "Birnavirus RNA-directed RNA polymerase, palm domain", "go_ids": ["GO:0003968", "GO:0019079"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0019079:viral genome replication:P"], "name": "Birnavirus_RdRp_palm", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007109": {"description": "Brix domain", "go_ids": ["GO:0019843", "GO:0006364"], "go_terms": ["GO:0019843:rRNA binding:F", "GO:0006364:rRNA processing:P"], "name": "Brix", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR007111": {"description": "NACHT nucleoside triphosphatase", "go_ids": [], "go_terms": [], "name": "NACHT_NTPase", "pathway_ids": ["R-HSA-5689901", "R-HSA-1606341", "R-RNO-9758274", "R-HSA-9020702", "R-HSA-9705671", "R-HSA-168638", "R-HSA-168928", "R-MMU-450302", "R-MMU-844455", "R-HSA-5689896", "R-MMU-5689901", "R-RNO-844455", "R-HSA-936440", "R-RNO-5689901", "R-MMU-5689896", "R-HSA-450321", "R-BTA-450321", "R-HSA-450302", "R-HSA-9707564", "R-MMU-168638", "R-BTA-168638", "R-HSA-844455", "R-BTA-5689901", "R-DRE-5689901", "R-HSA-3270619", "R-MMU-3270619", "R-BTA-5689896", "R-HSA-6803207", "R-MMU-3134975", "R-HSA-9758274", "R-HSA-9660826", "R-MMU-450321", "R-RNO-844456", "R-MMU-844456", "R-BTA-844456", "R-DRE-844456", "R-BTA-450302", "R-HSA-877300", "R-RNO-936440", "R-HSA-9692916", "R-HSA-3134975", "R-MMU-936440", "R-MMU-9758274", "R-HSA-844456", "R-HSA-445989", "R-HSA-844623"], "pathways": ["R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-844455:r:The NLRP1 inflammasome", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689901:r:Metalloprotease DUBs", "R-RNO-844455:r:The NLRP1 inflammasome", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-5689901:r:Metalloprotease DUBs", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-844455:r:The NLRP1 inflammasome", "R-BTA-5689901:r:Metalloprotease DUBs", "R-DRE-5689901:r:Metalloprotease DUBs", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-BTA-844456:r:The NLRP3 inflammasome", "R-DRE-844456:r:The NLRP3 inflammasome", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-877300:r:Interferon gamma signaling", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR007112": {"description": "Expansin/pollen allergen, DPBB domain", "go_ids": [], "go_terms": [], "name": "Expansin/allergen_DPBB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007115": {"description": "6-pyruvoyl tetrahydropterin synthase/QueD family", "go_ids": [], "go_terms": [], "name": "6-PTP_synth/QueD", "pathway_ids": ["PWY-6703", "R-DME-1474151", "R-DDI-1474151", "R-CEL-1474151", "R-HSA-1474151", "R-MMU-1474151", "R-RNO-1474151"], "pathways": ["PWY-6703:t:preQ0 biosynthesis", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "type": "Family"}, "IPR007117": {"description": "Expansin, cellulose-binding-like domain", "go_ids": [], "go_terms": [], "name": "Expansin_CBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007119": {"description": "Phage tail spike protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Phage_tail_spike_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007120": {"description": "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "DNA-dir_RNAP_su2_dom", "pathway_ids": ["R-CEL-73779", "R-HSA-73772", "R-DME-76061", "R-HSA-6807505", "R-SPO-674695", "R-CEL-72165", "R-MMU-75953", "R-MMU-9770562", "R-HSA-73980", "R-CEL-72203", "R-HSA-427413", "R-DDI-73776", "R-DME-72163", "R-DDI-6782210", "R-SPO-6781823", "R-DME-75955", "R-DDI-72163", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-BTA-9018519", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-DME-72203", "R-DME-72086", "R-DDI-674695", "R-CEL-9770562", "R-MMU-76061", "R-CEL-75953", "R-HSA-76061", "R-DME-75953", "R-SPO-6796648", "R-HSA-749476", "R-CEL-73776", "R-DME-6782135", "R-BTA-72163", "R-SCE-76061", "R-BTA-75955", "R-DME-73762", "R-BTA-75953", "R-SPO-9018519", "R-BTA-6782135", "R-SPO-76066", "R-MMU-72163", "R-HSA-6803529", "R-HSA-167242", "R-CEL-6782210", "R-HSA-8851708", "R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-CEL-112382", "R-HSA-9670095", "R-HSA-167160", "R-CEL-6782135", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-MMU-73772", "R-DDI-113418", "R-MMU-72086", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-DME-5578749", "R-DME-77075", "R-DME-73779", "R-BTA-5578749", "R-CEL-73772", "R-DME-9770562", "R-DME-73776", "R-BTA-6781823", "R-MMU-6781823", "R-HSA-203927", "R-DDI-73772", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-DDI-76042", "R-MMU-73776", "R-HSA-73780", "R-CEL-72163", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-DME-113418", "R-HSA-76071", "R-HSA-72203", "R-CEL-75955", "R-MMU-6796648", "R-BTA-72165", "R-HSA-9770562", "R-HSA-167243", "R-DRE-73772", "R-SCE-6781823", "R-MMU-76071", "R-BTA-674695", "R-SCE-9018519", "R-BTA-6803529", "R-DME-76066", "R-HSA-167290", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-CEL-9018519", "R-DME-6782210", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-SPO-72163", "R-BTA-6807505", "R-BTA-72203", "R-HSA-112382", "R-HSA-73779", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-DME-6781823", "R-DME-76042", "R-MMU-113418", "R-BTA-76042", "R-SPO-6807505", "R-RNO-73863", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-HSA-5601884", "R-SPO-75953", "R-SPO-73762", "R-SPO-113418", "R-MMU-5250924", "R-CEL-6807505", "R-DME-674695", "R-DDI-73779", "R-BTA-72086", "R-DME-9018519", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-CEL-113418", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-DRE-5250924", "R-MMU-6807505", "R-SCE-76042", "R-CEL-6781823", "R-DDI-6807505", "R-DME-6807505", "R-SPO-9770562", "R-MMU-9018519", "R-HSA-167200", "R-DME-72165", "R-SCE-73762", "R-SCE-674695", "R-BTA-9770562", "R-MMU-6782210", "R-CEL-6796648", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-SCE-76066", "R-MMU-73762", "R-MMU-6782135", "R-BTA-113418", "R-HSA-76066", "R-HSA-9639775", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-DRE-73762", "R-HSA-167162", "R-DRE-73863", "R-DDI-76061", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-BTA-112382", "R-SCE-6782210", "R-BTA-6796648", "R-HSA-9918481", "R-SCE-72203", "R-SCE-6796648", "R-SPO-72203", "R-SPO-77075", "R-RNO-73772", "R-SCE-113418", "R-SCE-72086", "R-MMU-73863", "R-RNO-5250924", "R-HSA-6782135", "R-HSA-73762", "R-CEL-77075", "R-SCE-77075", "R-HSA-5250924", "R-DDI-75953", "R-SPO-6782135", "R-CEL-73762", "R-DME-73772", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-DME-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-72086:r:mRNA Capping", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-6782135:r:Dual incision in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-73762:r:RNA Polymerase I Transcription Initiation", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-BTA-6782135:r:Dual incision in TC-NER", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-DME-9770562:r:mRNA Polyadenylation", 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Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-DRE-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Domain"}, 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transcription", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-5689901:r:Metalloprotease DUBs", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-SSC-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-SCE-3214858:r:RMTs methylate histone arginines", "R-BTA-171306:r:Packaging Of Telomere Ends", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-GGA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-9018519:r:Estrogen-dependent gene 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arginines", "R-RNO-3214815:r:HDACs deacetylate histones", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214842:r:HDMs demethylate histones", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-MMU-5689603:r:UCH proteinases", "R-HSA-9833110:r:RSV-host interactions", "R-CEL-3214842:r:HDMs demethylate histones", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-3214847:r:HATs acetylate histones", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DRE-2299718:r:Condensation of Prophase Chromosomes", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DRE-5689880:r:Ub-specific processing proteases", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-GGA-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-SSC-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-GGA-2299718:r:Condensation of Prophase Chromosomes", "R-SSC-2299718:r:Condensation of Prophase Chromosomes", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-SSC-201722:r:Formation of the beta-catenin:TCF transactivating complex"], "type": "Domain"}, "IPR007126": {"description": "Borrelia REV", "go_ids": [], "go_terms": [], "name": "Borrelia_REV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007127": {"description": "RNA polymerase sigma factor 70, region 1.1", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RNA_pol_sigma_70_r1_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007128": {"description": "Nuclear MIS12/MIND complex subunit PMF1/Nnf1", "go_ids": ["GO:0000444"], "go_terms": ["GO:0000444:MIS12/MIND type complex:C"], "name": "PMF1/Nnf1", "pathway_ids": ["R-MMU-2500257", "R-BTA-2467813", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-MMU-2467813", "R-BTA-2500257", "R-MMU-9648025", "R-HSA-5663220", "R-HSA-141444", "R-BTA-5663220", "R-HSA-9648025", "R-BTA-9648025", "R-MMU-68877", "R-BTA-141444", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR007129": {"description": "Ubiquinol-cytochrome c chaperone, CBP3", "go_ids": [], "go_terms": [], "name": "Ubiqinol_cyt_c_chaperone_CPB3", "pathway_ids": ["R-SCE-9865878", "R-HSA-9865881"], "pathways": ["R-SCE-9865878:r:Complex III assembly", "R-HSA-9865881:r:Complex III assembly"], "type": "Family"}, "IPR007130": {"description": "Diacylglycerol acyltransferase", "go_ids": ["GO:0016747"], "go_terms": ["GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "DAGAT", "pathway_ids": ["R-DDI-2142753", "R-SCE-2142753", "R-SCE-75109", "R-MMU-75109", "R-SPO-9640463", "R-DDI-2187335", "R-SPO-2142753", 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{"description": "SLA1 homology domain 1, SHD1", "go_ids": ["GO:0008092", "GO:0030674", "GO:0043130", "GO:0042802"], "go_terms": ["GO:0008092:cytoskeletal protein binding:F", "GO:0030674:protein-macromolecule adaptor activity:F", "GO:0043130:ubiquitin binding:F", "GO:0042802:identical protein binding:F"], "name": "SHD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007132": {"description": "Protein of unknown function DUF346", "go_ids": [], "go_terms": [], "name": "DUF346", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR007133": {"description": "RNA polymerase II associated factor Paf1", "go_ids": ["GO:0016593", "GO:0006368"], "go_terms": ["GO:0016593:Cdc73/Paf1 complex:C", "GO:0006368:transcription elongation by RNA polymerase II:P"], "name": "RNA_pol_II-assoc_Paf1", "pathway_ids": ["R-MMU-8866654", "R-BTA-75955", "R-CEL-75955", "R-XTR-674695", "R-RNO-674695", "R-HSA-9920588", "R-RNO-75955", "R-XTR-75955", "R-BTA-674695", "R-XTR-112382", "R-RNO-8866654", 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"R-HSA-6790901", "R-BTA-9930044", "R-RNO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-DRE-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-9930044:r:Nuclear RNA decay", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-BTA-9930044:r:Nuclear RNA decay", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR007147": {"description": "Transcription factor Vhr", "go_ids": [], "go_terms": [], "name": "TF_Vhr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007148": {"description": "Small-subunit processome, Utp12", "go_ids": [], "go_terms": [], "name": "SSU_processome_Utp12", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR007149": {"description": "Leo1-like protein", "go_ids": ["GO:0016593", "GO:0006368"], "go_terms": ["GO:0016593:Cdc73/Paf1 complex:C", "GO:0006368:transcription elongation by RNA polymerase II:P"], "name": "Leo1", "pathway_ids": ["R-MMU-8866654", "R-CEL-75955", "R-DME-8866654", "R-RNO-674695", "R-RNO-201722", "R-HSA-9920588", "R-DME-674695", "R-RNO-75955", "R-DRE-201722", "R-MMU-201722", "R-CEL-201722", "R-DME-75955", "R-RNO-8866654", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-DME-201722", "R-CEL-674695", "R-DRE-75955", "R-HSA-8866654", "R-HSA-201722", "R-DME-112382", "R-DRE-674695", "R-RNO-112382", "R-CEL-112382", "R-HSA-75955", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Family"}, "IPR007150": {"description": "HUS1/Mec3", "go_ids": ["GO:0000077", "GO:0030896"], "go_terms": ["GO:0000077:DNA damage checkpoint signaling:P", "GO:0030896:checkpoint clamp complex:C"], "name": "HUS1/Mec3", "pathway_ids": ["R-MMU-69473", "R-SPO-176187", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-MMU-5685938", "R-HSA-5693616", "R-HSA-69473", "R-SCE-176187", "R-MMU-176187", "R-MMU-6804756", "R-HSA-176187", "R-HSA-5685938", "R-MMU-5693607", "R-DME-176187"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Family"}, "IPR007152": {"description": "Protein of unknown function DUF354", "go_ids": [], "go_terms": [], "name": "DUF354", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007153": {"description": "Adenosine specific kinase", "go_ids": [], "go_terms": [], "name": "Adenosine_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007154": {"description": "Protein of unknown function DUF356", "go_ids": [], "go_terms": [], "name": "DUF356", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007156": {"description": "MamQ/LemA", "go_ids": [], "go_terms": [], "name": "MamQ_LemA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007157": {"description": "PspA/VIPP1", "go_ids": [], "go_terms": [], "name": "PspA_VIPP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007158": {"description": "tRNA (pseudouridine(54)-N(1))-methyltransferase, TrmY", "go_ids": ["GO:0008175"], "go_terms": ["GO:0008175:tRNA methyltransferase activity:F"], "name": "TrmY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007159": {"description": "SpoVT-AbrB domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "SpoVT-AbrB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007160": {"description": "Domain of unknown function DUF362", "go_ids": [], "go_terms": [], "name": "DUF362", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007161": {"description": "Putative heavy-metal chelation domain", "go_ids": [], "go_terms": [], "name": "DUF364", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007162": {"description": "Protein of unknown function DUF366", "go_ids": [], "go_terms": [], "name": "DUF366", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007163": {"description": "Undecaprenyl phosphate translocase-like", "go_ids": [], "go_terms": [], "name": "VCA0040-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007164": {"description": "GTP-dependent dephospho-CoA kinase", "go_ids": ["GO:0015937", "GO:0016301"], "go_terms": ["GO:0015937:coenzyme A biosynthetic process:P", "GO:0016301:kinase activity:F"], "name": "GTP-dep_dephospho-CoA_kin", "pathway_ids": ["PWY-8342"], "pathways": ["PWY-8342:t:coenzyme A biosynthesis III (archaea)"], "type": "Family"}, "IPR007165": {"description": "Mycobacterial 4 TMS phage holin, superfamily IV", "go_ids": [], "go_terms": [], "name": "Phage_holin_4_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007166": {"description": "Class III signal peptide motif", "go_ids": [], "go_terms": [], "name": "Class3_signal_pept_motif", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR007167": {"description": "Ferrous iron transporter FeoA-like domain", "go_ids": ["GO:0046914"], "go_terms": ["GO:0046914:transition metal ion binding:F"], "name": "Fe-transptr_FeoA-like", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR007168": {"description": "Phage shock protein, PspC, N-terminal", "go_ids": [], "go_terms": [], "name": "Phageshock_PspC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007169": {"description": "Extracellular matrix regulatory protein A-like", "go_ids": [], "go_terms": [], "name": "RemA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007170": {"description": "Stage V sporulation protein G", "go_ids": ["GO:0030435"], "go_terms": ["GO:0030435:sporulation resulting in formation of a cellular spore:P"], "name": "SpoVG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007171": {"description": "Protein of unknown function DUF371", "go_ids": [], "go_terms": [], "name": "DUF371", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007172": {"description": "Domain of unknown function DUF374", "go_ids": [], "go_terms": [], "name": "DUF374", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007173": {"description": "D-arabinono-1,4-lactone oxidase, C-terminal domain", "go_ids": ["GO:0003885", "GO:0016020"], "go_terms": ["GO:0003885:D-arabinono-1,4-lactone oxidase activity:F", "GO:0016020:membrane:C"], "name": "ALO_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007174": {"description": "Las1", "go_ids": ["GO:0004519", "GO:0006364", "GO:0090730"], "go_terms": ["GO:0004519:endonuclease activity:F", "GO:0006364:rRNA processing:P", "GO:0090730:Las1 complex:C"], "name": "Las1", "pathway_ids": ["R-SCE-6791226", "R-SPO-6791226", "R-MMU-6791226", "R-HSA-6791226"], "pathways": ["R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR007175": {"description": "Ribonuclease P subunit, Rpr2/Snm1/Rpp21", "go_ids": ["GO:0006396"], "go_terms": ["GO:0006396:RNA processing:P"], "name": "Rpr2/Snm1/Rpp21", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6784531"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR007176": {"description": "Protein of unknown function DUF365", "go_ids": [], "go_terms": [], "name": "DUF365", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007177": {"description": "16S/18S rRNA aminocarboxypropyltransferase Tsr3, C-terminal", "go_ids": [], "go_terms": [], "name": "Tsr3_C", "pathway_ids": ["PWY-8341", "R-HSA-6790901"], "pathways": ["PWY-8341:t:N1-methyl-N3-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR007178": {"description": "Transcription elongation factor Spt4, archaea", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Spt4_arch", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007180": {"description": "Domain of unknown function DUF382", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "DUF382", "pathway_ids": ["R-HSA-72165", "R-HSA-72163", "R-SPO-9770562", "R-MMU-72165", "R-HSA-9770562", "R-HSA-9918481", "R-MMU-9770562", "R-MMU-72163"], "pathways": ["R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR007181": {"description": "Dihydroneopterin aldolase MtpD, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MtpD_C", "pathway_ids": ["PWY-6147", "PWY-6148", "PWY-6797", "PWY-7539"], "pathways": ["PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)"], "type": "Domain"}, "IPR007182": {"description": "Na+/H+ antiporter MnhB subunit-related protein", "go_ids": [], "go_terms": [], "name": "MnhB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007183": {"description": "Uncharacterised protein family UPF0280", "go_ids": [], "go_terms": [], "name": "UPF0280", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007184": {"description": "Mannoside phosphorylase", "go_ids": [], "go_terms": [], "name": "Mannoside_phosphorylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007185": {"description": "DNA polymerase alpha/delta/epsilon, subunit B", "go_ids": ["GO:0003677", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006260:DNA replication:P"], "name": "DNA_pol_a/d/e_bsu", "pathway_ids": ["R-BTA-174411", "R-BTA-5358606", "R-DME-110314", "R-CEL-69091", "R-RNO-174437", "R-CEL-68962", "R-HSA-174414", "R-SPO-5656169", "R-SCE-69091", "R-MMU-174417", "R-HSA-5696397", "R-CEL-113501", "R-DDI-6782210", "R-CEL-69166", "R-RNO-110314", "R-DME-113501", "R-RNO-69183", "R-MMU-110314", "R-DME-5696400", "R-HSA-174417", "R-CEL-110314", "R-DDI-68952", "R-MMU-174414", "R-DDI-68962", "R-RNO-5696397", "R-SPO-69091", "R-DME-68962", "R-DME-69183", "R-MMU-174437", "R-BTA-5696397", "R-RNO-5656169", "R-BTA-110314", "R-MMU-5358606", "R-BTA-69183", "R-DME-6782135", "R-SCE-68952", "R-SPO-69166", "R-MMU-5358565", "R-RNO-6782210", "R-DME-5651801", "R-SCE-69183", "R-HSA-68952", "R-DDI-113501", "R-MMU-5651801", "R-MMU-68962", "R-RNO-174430", "R-BTA-6782135", "R-HSA-174430", "R-DDI-69183", "R-DME-69091", "R-CEL-6782210", "R-MMU-69183", "R-HSA-9710421", "R-RNO-113501", "R-SPO-68952", "R-SPO-110314", "R-SCE-69166", "R-CEL-6782135", "R-BTA-6782210", "R-MMU-6782210", "R-CEL-5651801", "R-MMU-5696397", "R-MMU-174411", "R-SCE-6782135", "R-SPO-5651801", "R-HSA-110314", "R-DDI-6782135", "R-RNO-174414", "R-MMU-174430", "R-RNO-68962", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-5358606", "R-BTA-174437", "R-BTA-174417", "R-RNO-69166", "R-CEL-69183", "R-BTA-5651801", "R-BTA-69166", "R-GGA-353303", "R-HSA-68962", "R-HSA-6782210", "R-CEL-5656169", "R-BTA-5656169", "R-DME-68952", "R-RNO-68952", "R-BTA-5696400", "R-HSA-5656169", "R-RNO-174411", "R-MMU-5696400", "R-HSA-113501", "R-SPO-5696397", "R-RNO-5358606", "R-RNO-5358565", "R-DDI-69091", "R-RNO-6782135", "R-SPO-69183", "R-MMU-5656169", "R-MMU-113501", "R-BTA-69091", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-174411", "R-HSA-5651801", "R-HSA-69166", "R-SCE-113501", "R-SCE-68962", "R-CEL-5696397", "R-DDI-69166", "R-RNO-69091", "R-RNO-5685942", "R-MMU-68952", "R-DME-5656169", "R-SPO-113501", "R-SPO-5696400", "R-CEL-68952", "R-BTA-5358565", "R-SPO-6782210", "R-MMU-69166", "R-HSA-69183", "R-BTA-5685942", "R-RNO-5696400", "R-RNO-174417", "R-SPO-68962", "R-HSA-5696400", "R-HSA-5358565", "R-BTA-174414", "R-SPO-6782135", "R-HSA-69091", "R-HSA-174437", "R-RNO-5651801", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-69091:r:Polymerase switching", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SCE-69091:r:Polymerase switching", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-5696400:r:Dual Incision in GG-NER", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-68952:r:DNA replication initiation", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SPO-69091:r:Polymerase switching", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-BTA-69183:r:Processive synthesis on the lagging strand", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-68952:r:DNA replication initiation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-HSA-68952:r:DNA replication initiation", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-DME-69091:r:Polymerase switching", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-HSA-9710421:r:Defective pyroptosis", "R-RNO-113501:r:Inhibition 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phagocytosis", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs"], "type": "Family"}, "IPR007191": {"description": "Exocyst complex component Sec8, N-terminal", "go_ids": ["GO:0000145", "GO:0006887"], "go_terms": ["GO:0000145:exocyst:C", "GO:0006887:exocytosis:P"], "name": "Sec8_exocyst_N", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Domain"}, "IPR007192": {"description": "Cdc23", "go_ids": ["GO:0005680"], "go_terms": ["GO:0005680:anaphase-promoting complex:C"], "name": "APC8", "pathway_ids": ["R-BTA-983168", "R-HSA-8853884", "R-HSA-174178", "R-SPO-176408", "R-HSA-2467813", "R-BTA-179409", "R-MMU-174154", "R-BTA-176412", "R-BTA-141430", "R-MMU-2467813", "R-MMU-69017", "R-MMU-179409", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-CEL-983168", "R-BTA-176409", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-BTA-174154", "R-BTA-2467813", "R-DDI-176409", "R-DDI-2559582", "R-SPO-983168", "R-DDI-2467813", "R-DDI-176412", "R-BTA-174184", "R-SCE-983168", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-BTA-174178", "R-BTA-176407", "R-MMU-174084", "R-BTA-68867", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-68867", "R-DDI-174084", "R-MMU-176409", "R-SPO-2559582", "R-BTA-174084", "R-HSA-176409", "R-HSA-9687136", "R-BTA-2559582", "R-BTA-174048", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-SPO-179409", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-DDI-174184", "R-MMU-141430", "R-HSA-69017", "R-DDI-141430", "R-BTA-69017", "R-BTA-176408", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-DDI-174178", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Domain"}, "IPR007193": {"description": "Up-frameshift suppressor 2, C-terminal", "go_ids": [], "go_terms": [], "name": "Upf2/Nmd2_C", "pathway_ids": ["R-HSA-975957", "R-SPO-975957", "R-SCE-975957", "R-HSA-9010553", "R-MMU-975957"], "pathways": ["R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Domain"}, "IPR007194": {"description": "Transport protein particle (TRAPP) component", "go_ids": [], "go_terms": [], "name": "TRAPP_component", "pathway_ids": ["R-MMU-204005", "R-DDI-204005", "R-DRE-204005", "R-PFA-204005", "R-SCE-204005", "R-SPO-204005", "R-RNO-8876198", "R-HSA-8876198", "R-SCE-8876198", "R-RNO-204005", "R-DRE-8876198", "R-HSA-204005", "R-MMU-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-PFA-8876198", "R-CEL-204005", "R-BTA-204005", "R-GGA-204005", "R-SPO-8876198"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-PFA-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-PFA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-GGA-204005:r:COPII-mediated vesicle transport", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR007195": {"description": "TolB, N-terminal", "go_ids": ["GO:0015031", "GO:0042597"], "go_terms": ["GO:0015031:protein transport:P", "GO:0042597:periplasmic space:C"], "name": "TolB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007196": {"description": "CCR4-Not complex component, Not1, C-terminal", "go_ids": [], "go_terms": [], "name": "CCR4-Not_Not1_C", "pathway_ids": ["R-XTR-429947", "R-MMU-6804115", "R-HSA-6804115", "R-XTR-6804115", "R-DRE-6804115", "R-HSA-429947", "R-MMU-429947", "R-HSA-9820841"], "pathways": ["R-XTR-429947:r:Deadenylation of mRNA", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR007197": {"description": "Radical SAM", "go_ids": ["GO:0003824", "GO:0051536"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "rSAM", "pathway_ids": ["R-DME-947581", "R-HSA-6782315", "R-DME-9857492", "R-PFA-9857492", "R-HSA-909733", "R-MMU-9857492", "R-MMU-947581", "R-DRE-9857492", "R-RNO-9857492", "R-HSA-6782861", "R-SCE-9857492", "R-BTA-9857492", "R-HSA-3214847", "R-DDI-947581", "R-HSA-9857492", "R-HSA-947581", "R-BTA-947581"], "pathways": ["R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-DME-9857492:r:Protein lipoylation", "R-PFA-9857492:r:Protein lipoylation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-MMU-9857492:r:Protein lipoylation", "R-MMU-947581:r:Molybdenum cofactor biosynthesis", "R-DRE-9857492:r:Protein lipoylation", "R-RNO-9857492:r:Protein lipoylation", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)", "R-SCE-9857492:r:Protein lipoylation", "R-BTA-9857492:r:Protein lipoylation", "R-HSA-3214847:r:HATs acetylate histones", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-9857492:r:Protein lipoylation", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR007198": {"description": "Ssl1-like", "go_ids": [], "go_terms": [], "name": "Ssl1-like", "pathway_ids": ["R-RNO-6781823", "R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-RNO-674695", "R-SCE-75953", "R-MMU-113418", "R-RNO-73779", "R-HSA-427413", "R-BTA-76042", "R-DDI-73776", "R-RNO-73863", "R-SPO-6781823", "R-DDI-6782210", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-RNO-73776", "R-HSA-6781823", "R-MMU-112382", "R-SPO-5696395", "R-SPO-76042", "R-HSA-167246", "R-HSA-73776", "R-MMU-5696395", "R-BTA-77075", "R-DDI-674695", "R-HSA-75953", "R-CEL-75953", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-CEL-73776", "R-MMU-76042", "R-SPO-75953", "R-RNO-6782210", "R-BTA-73863", "R-BTA-75955", "R-SPO-113418", "R-BTA-75953", "R-DDI-73779", "R-RNO-76042", "R-BTA-72086", "R-BTA-6782135", "R-RNO-5696395", "R-DDI-6781823", "R-CEL-113418", "R-CEL-6782210", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-SCE-76042", "R-CEL-6781823", "R-CEL-674695", "R-HSA-167161", "R-HSA-167200", "R-RNO-112382", "R-CEL-112382", "R-CEL-5696395", "R-CEL-6782135", "R-SCE-674695", "R-HSA-167160", "R-HSA-5696395", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-DDI-113418", "R-MMU-73772", "R-MMU-6782210", "R-MMU-72086", "R-BTA-73776", "R-CEL-6796648", "R-SPO-73776", "R-RNO-75953", "R-BTA-73772", "R-SCE-73776", "R-SCE-6782135", "R-DDI-6782135", "R-MMU-73762", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-BTA-113418", "R-CEL-72086", "R-HSA-72086", "R-CEL-73772", "R-HSA-167162", "R-BTA-6781823", "R-MMU-6781823", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696395", "R-BTA-5696400", "R-SCE-6782210", "R-HSA-167172", "R-BTA-6796648", "R-MMU-5696400", "R-BTA-73779", "R-SCE-6796648", "R-SCE-73779", "R-RNO-72086", "R-RNO-113418", "R-SPO-77075", "R-CEL-75955", "R-RNO-73772", "R-BTA-73762", "R-MMU-6796648", "R-RNO-6796648", "R-RNO-75955", "R-RNO-6782135", "R-SCE-113418", "R-SCE-72086", "R-SCE-6781823", "R-MMU-73863", "R-HSA-6782135", "R-BTA-674695", "R-HSA-73762", "R-CEL-77075", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-SPO-5696400", "R-HSA-75955", "R-SCE-77075", "R-SPO-6782210", "R-MMU-77075", "R-RNO-5696400", "R-HSA-5696400", "R-HSA-76042", "R-SPO-6782135", "R-HSA-674695", "R-SCE-73772", "R-DDI-75953", "R-CEL-76042", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-72086:r:mRNA Capping", "R-BTA-6782135:r:Dual incision in TC-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-72086:r:mRNA Capping", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR007199": {"description": "Replication factor-A protein 1, N-terminal", "go_ids": ["GO:0003677", "GO:0005634", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006260:DNA replication:P"], "name": "Rep_factor-A_N", "pathway_ids": ["R-HSA-5693616", "R-GGA-174437", "R-HSA-5696397", "R-GGA-110314", "R-MMU-110320", "R-MMU-6804756", "R-GGA-351468", "R-HSA-5655862", "R-MMU-5685938", "R-MMU-110314", "R-MMU-69473", "R-MMU-5696395", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-MMU-174437", "R-GGA-6782135", "R-HSA-5656121", "R-GGA-5696400", "R-MMU-5358606", "R-MMU-5358565", "R-GGA-68962", "R-DRE-6804756", "R-DRE-6782210", "R-GGA-110320", "R-HSA-69473", "R-MMU-5651801", "R-MMU-68962", "R-DRE-5685942", "R-HSA-110312", "R-GGA-6782210", "R-HSA-6783310", "R-DRE-3371453", "R-DRE-174437", "R-GGA-110312", "R-GGA-5656169", "R-HSA-6804756", "R-GGA-5358565", "R-GGA-5651801", "R-DRE-69473", "R-HSA-5696395", "R-DRE-5358565", "R-MMU-176187", "R-MMU-6782210", "R-MMU-3108214", "R-GGA-5693607", "R-MMU-5696397", "R-GGA-176187", "R-HSA-110314", "R-HSA-3371511", "R-DRE-5358606", "R-DRE-5693607", "R-GGA-5685938", "R-DRE-176187", "R-HSA-3108214", "R-HSA-5685942", "R-GGA-3108214", "R-GGA-5685942", "R-MMU-6782135", "R-GGA-5358606", "R-HSA-5358606", "R-DRE-5656121", "R-DRE-5696400", "R-MMU-110312", "R-GGA-5655862", "R-DRE-5656169", "R-DRE-5696395", "R-DRE-69166", "R-DRE-3108214", "R-GGA-353303", "R-HSA-912446", "R-HSA-68962", "R-HSA-6782210", "R-HSA-5656169", "R-DRE-110312", "R-HSA-5685938", "R-HSA-176187", "R-MMU-5696400", "R-MMU-5693607", "R-MMU-3371453", "R-MMU-5655862", "R-GGA-6783310", "R-GGA-351451", "R-DRE-5696397", "R-GGA-5696397", "R-GGA-5656121", "R-DRE-5655862", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-HSA-69166", "R-GGA-3371453", "R-GGA-5696395", "R-MMU-6783310", "R-MMU-5656121", "R-DRE-110320", "R-DRE-6782135", "R-DRE-68962", "R-MMU-69166", "R-HSA-5696400", "R-HSA-5358565", "R-DRE-5651801", "R-DRE-110314", "R-HSA-174437", "R-GGA-69166", "R-HSA-110320", "R-DRE-5685938"], "pathways": ["R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-GGA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-351468:r:Processing of DNA double-strand break ends", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-6782135:r:Dual incision in TC-NER", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-GGA-68962:r:Activation of the pre-replicative complex", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-110312:r:Translesion synthesis by REV1", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-GGA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-3371511:r:HSF1 activation", "R-DRE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DRE-176187:r:Activation of ATR in response to replication stress", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-GGA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DRE-5656121:r:Translesion synthesis by POLI", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-MMU-110312:r:Translesion synthesis by REV1", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-DRE-5656169:r:Termination of translesion DNA synthesis", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-69166:r:Removal of the Flap Intermediate", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-912446:r:Meiotic recombination", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DRE-110312:r:Translesion synthesis by REV1", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-GGA-6783310:r:Fanconi Anemia Pathway", "R-GGA-351451:r:Homologous recombination repair of replication-dependent double-strand breaks", "R-DRE-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-DRE-5655862:r:Translesion synthesis by POLK", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-GGA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-DRE-6782135:r:Dual incision in TC-NER", "R-DRE-68962:r:Activation of the pre-replicative complex", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-69166:r:Removal of the Flap Intermediate", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR007201": {"description": "Mei2-like, C-terminal RNA recognition motif", "go_ids": [], "go_terms": [], "name": "Mei2-like_Rrm_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007202": {"description": "4Fe-4S domain", "go_ids": ["GO:0051536"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F"], "name": "4Fe-4S_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007203": {"description": "ORMDL family", "go_ids": ["GO:0016020", "GO:0005789"], "go_terms": ["GO:0016020:membrane:C", "GO:0005789:endoplasmic reticulum membrane:C"], "name": "ORMDL", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-MMU-1660661", "R-DRE-6798695", "R-DME-6798695", "R-SCE-6798695", "R-RNO-1660661", "R-MMU-6798695", "R-BTA-6798695", "R-DRE-1660661", "R-HSA-1660661", "R-DME-1660661", "R-RNO-6798695", "R-BTA-1660661"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DRE-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR007204": {"description": "Actin-related protein 2/3 complex subunit 3", "go_ids": ["GO:0005856", "GO:0005885", "GO:0034314"], "go_terms": ["GO:0005856:cytoskeleton:C", "GO:0005885:Arp2/3 protein complex:C", "GO:0034314:Arp2/3 complex-mediated actin nucleation:P"], "name": "ARPC3", "pathway_ids": ["R-HSA-5663213", "R-DDI-2029482", "R-BTA-8856828", "R-BTA-2029482", "R-MMU-8856828", "R-CEL-8856828", "R-SPO-2029482", "R-HSA-8856828", "R-BTA-3928662", "R-DDI-5663213", "R-HSA-2029482", "R-CEL-5663213", "R-MMU-2029482", "R-HSA-3928662", "R-SPO-5663213", "R-CEL-2029482", "R-MMU-5663213", "R-BTA-5663213", "R-SCE-5663213", "R-SCE-2029482", "R-MMU-3928662", "R-CEL-3928662", "R-HSA-9664422"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-SPO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis"], "type": "Family"}, "IPR007205": {"description": "Protein HGH1 N-terminal", "go_ids": [], "go_terms": [], "name": "Protein_HGH1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007206": {"description": "Protein HGH1 C-terminal", "go_ids": [], "go_terms": [], "name": "Protein_HGH1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007207": {"description": "CCR4-Not complex component, Not N-terminal domain", "go_ids": ["GO:0005634", "GO:0006355"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Not_N", "pathway_ids": ["R-MMU-6804115", "R-HSA-6804115", "R-MMU-429947", "R-HSA-429947", "R-HSA-9820841"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR007208": {"description": "Na(+)/H(+) antiporter subunit F-like", "go_ids": ["GO:0015075", "GO:0016020", "GO:0034220"], "go_terms": ["GO:0015075:monoatomic ion transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0034220:monoatomic ion transmembrane transport:P"], "name": "MrpF/PhaF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007209": {"description": "RNase L inhibitor RLI-like, possible metal-binding domain", "go_ids": [], "go_terms": [], "name": "RNaseL-inhib-like_metal-bd_dom", "pathway_ids": ["PWY-8341", "R-HSA-8983711", "R-MMU-9954714", "R-HSA-909733", "R-DME-9954714", "R-SPO-9954714", "R-MMU-909733", "R-HSA-9954714", "R-SCE-9954714", "R-HSA-6790901", "R-MMU-8983711"], "pathways": ["PWY-8341:t:N1-methyl-N3-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis", "R-HSA-8983711:r:OAS antiviral response", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-MMU-8983711:r:OAS antiviral response"], "type": "Domain"}, "IPR007210": {"description": "ABC-type glycine betaine transport system, substrate-binding domain", "go_ids": ["GO:0022857", "GO:0055085", "GO:0043190"], "go_terms": ["GO:0022857:transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P", "GO:0043190:ATP-binding cassette (ABC) transporter complex:C"], "name": "ABC_Gly_betaine_transp_sub-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007211": {"description": "Protein of unknown function DUF378", "go_ids": [], "go_terms": [], "name": "DUF378", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007212": {"description": "Cysteine-rich small domain", "go_ids": [], "go_terms": [], "name": "Zf-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007213": {"description": "Methyltransferase Ppm1/Ppm2/Tcmp", "go_ids": ["GO:0008168", "GO:0032259"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0032259:methylation:P"], "name": "Ppm1/Ppm2/Tcmp", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-6782861", "R-CEL-69273", "R-HSA-69273", "R-SPO-69273", "R-BTA-69273", "R-SCE-69273", "R-RNO-69273"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition"], "type": "Family"}, "IPR007214": {"description": "YbaK/aminoacyl-tRNA synthetase-associated domain", "go_ids": ["GO:0002161"], "go_terms": ["GO:0002161:aminoacyl-tRNA deacylase activity:F"], "name": "YbaK/aa-tRNA-synth-assoc-dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007215": {"description": "Sulphur relay, TusB/DsrH", "go_ids": ["GO:0005737", "GO:0002143"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0002143:tRNA wobble position uridine thiolation:P"], "name": "Sulphur_relay_TusB/DsrH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007216": {"description": "CCR4-NOT transcription complex subunit 9", "go_ids": ["GO:0030014", "GO:0006402"], "go_terms": ["GO:0030014:CCR4-NOT complex:C", "GO:0006402:mRNA catabolic process:P"], "name": "CNOT9", "pathway_ids": ["R-HSA-5617472", "R-HSA-6804115", "R-MMU-429947", "R-BTA-429947", "R-HSA-429947", "R-HSA-9820841", "R-MMU-6804115", "R-DRE-6804115", "R-BTA-6804115", "R-RNO-6804115"], "pathways": ["R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-BTA-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Family"}, "IPR007217": {"description": "Per1-like", "go_ids": ["GO:0006506"], "go_terms": ["GO:0006506:GPI anchor biosynthetic process:P"], "name": "Per1-like", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Family"}, "IPR007218": {"description": "DNA polymerase delta, subunit 4", "go_ids": ["GO:0006260", "GO:0000731"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0000731:DNA synthesis involved in DNA repair:P"], "name": "DNA_pol_delta_4", "pathway_ids": ["R-HSA-5685942", "R-MMU-6782135", "R-HSA-174414", "R-SPO-5656169", "R-MMU-174417", "R-HSA-5358606", "R-HSA-5696397", "R-MMU-110314", "R-HSA-174417", "R-MMU-174414", "R-SPO-69091", "R-MMU-174437", "R-HSA-6782210", "R-HSA-5656169", "R-MMU-5358606", "R-SPO-69166", "R-MMU-5696400", "R-MMU-5358565", "R-SPO-5696397", "R-MMU-5651801", "R-SPO-69183", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-HSA-174411", "R-MMU-69183", "R-HSA-69166", "R-SPO-5696400", "R-SPO-6782210", "R-SPO-110314", "R-MMU-69166", "R-HSA-69183", "R-HSA-5696400", "R-HSA-5358565", "R-MMU-6782210", "R-HSA-69091", "R-SPO-6782135", "R-MMU-174411", "R-HSA-174437", "R-MMU-5696397", "R-MMU-69091", "R-HSA-110314", "R-SPO-5651801"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-69091:r:Polymerase switching", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69091:r:Polymerase switching", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-69091:r:Polymerase switching", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR007219": {"description": "Xylanolytic transcriptional activator, regulatory domain", "go_ids": ["GO:0003677", "GO:0006351", "GO:0008270"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006351:DNA-templated transcription:P", "GO:0008270:zinc ion binding:F"], "name": "XnlR_reg_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007220": {"description": "Origin recognition complex, subunit 2", "go_ids": ["GO:0000808", "GO:0005634", "GO:0006260"], "go_terms": ["GO:0000808:origin recognition complex:C", "GO:0005634:nucleus:C", "GO:0006260:DNA replication:P"], "name": "ORC2", "pathway_ids": ["R-DDI-68689", "R-RNO-68949", "R-HSA-68949", "R-SPO-68616", "R-RNO-68962", "R-CEL-68962", "R-HSA-113507", "R-MMU-68949", "R-RNO-176187", "R-HSA-68616", "R-DME-68962", "R-DDI-68962", "R-RNO-68616", "R-HSA-68962", "R-SCE-176187", "R-CEL-68616", "R-HSA-176187", "R-DME-68949", "R-RNO-68689", "R-DDI-68616", "R-DME-176187", "R-HSA-68867", "R-SPO-176187", "R-MMU-68962", "R-HSA-68689", "R-SCE-68962", "R-DME-68616", "R-SCE-68616", "R-DME-68689", "R-CEL-68949", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-CEL-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-68949:r:Orc1 removal from chromatin", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin"], "type": "Family"}, "IPR007221": {"description": "Rod shape-determining protein MreC", "go_ids": ["GO:0008360"], "go_terms": ["GO:0008360:regulation of cell shape:P"], "name": "MreC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007222": {"description": "Signal recognition particle receptor, alpha subunit, N-terminal", "go_ids": ["GO:0003924", "GO:0005047", "GO:0005525", "GO:0005785", "GO:0006886"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005047:signal recognition particle binding:F", "GO:0005525:GTP binding:F", "GO:0005785:signal recognition particle receptor complex:C", "GO:0006886:intracellular protein transport:P"], "name": "SRPRA_N", "pathway_ids": ["R-HSA-1799339", "R-HSA-381038"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-381038:r:XBP1(S) activates chaperone genes"], "type": "Domain"}, "IPR007223": {"description": "Peroxin 13, N-terminal", "go_ids": ["GO:0005777", "GO:0016020", "GO:0016560"], "go_terms": ["GO:0005777:peroxisome:C", "GO:0016020:membrane:C", "GO:0016560:protein import into peroxisome matrix, docking:P"], "name": "Peroxin-13_N", "pathway_ids": ["R-MMU-8866654", "R-BTA-9603798", "R-SPO-9603798", "R-RNO-9603798", "R-DDI-9603798", "R-MMU-9033241", "R-RNO-8866654", "R-BTA-9033241", "R-HSA-8866654", "R-RNO-9033241", "R-SPO-9033241", "R-SCE-9603798", "R-BTA-8866654", "R-SCE-9033241", "R-CEL-9603798", "R-MMU-9603798", "R-DDI-9033241", "R-HSA-9603798", "R-HSA-9033241", "R-DDI-8866654"], "pathways": ["R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-9033241:r:Peroxisomal protein import", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-9033241:r:Peroxisomal protein import", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Domain"}, "IPR007224": {"description": "Transcription initiation factor Rrn11, conserved region", "go_ids": ["GO:0006361", "GO:0001164", "GO:0001181"], "go_terms": ["GO:0006361:transcription initiation at RNA 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cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Family"}, "IPR007226": {"description": "SRS domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "SRS_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007227": {"description": "Cell shape-determining protein MreD", "go_ids": ["GO:0008360", "GO:0016020"], "go_terms": ["GO:0008360:regulation of cell shape:P", "GO:0016020:membrane:C"], "name": "Cell_shape_determining_MreD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007229": {"description": "Nicotinate phosphoribosyltransferase family", "go_ids": ["GO:0004516"], "go_terms": ["GO:0004516:nicotinate phosphoribosyltransferase activity:F"], "name": "Nic_PRibTrfase-Fam", "pathway_ids": ["PWY-5381", "R-MMU-196807", "R-DDI-6798695", "R-HSA-6798695", "R-DRE-6798695", "R-DME-196807", "R-DME-6798695", "R-DRE-196807", "R-CEL-6798695", "R-CEL-196807", "R-HSA-196807", "R-MMU-6798695", "R-DDI-196807", "R-RNO-6798695", "R-RNO-196807"], "pathways": ["PWY-5381:t:NAD salvage (plants)", "R-MMU-196807:r:Nicotinate metabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-196807:r:Nicotinate metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-DRE-196807:r:Nicotinate metabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-196807:r:Nicotinate metabolism"], "type": "Family"}, "IPR007230": {"description": "Nuclear pore complex 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"R-MMU-8876198", "R-DDI-8876198", "R-MMU-6798695", "R-BTA-204005", "R-SPO-8876198", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-3000170:r:Syndecan interactions", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR007234": {"description": "Vps53, N-terminal", "go_ids": [], "go_terms": [], "name": "Vps53_N", "pathway_ids": ["R-HSA-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR007235": {"description": "Glycosyl transferase, family 28, C-terminal", "go_ids": ["GO:0016758"], "go_terms": ["GO:0016758:hexosyltransferase activity:F"], "name": "Glyco_trans_28_C", "pathway_ids": ["PWY-6470", "PWY-6471", "PWY-5265", "PWY-6385", "R-HSA-5633231", "R-RNO-446193", "R-HSA-446193", "R-SPO-446193"], "pathways": ["PWY-6470:t:peptidoglycan biosynthesis V (beta-lactam resistance)", "PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan 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"R-SPO-68952:r:DNA replication initiation", "R-CEL-68952:r:DNA replication initiation", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-69091:r:Polymerase switching", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Family"}, "IPR007239": {"description": "Autophagy-related protein 5", "go_ids": ["GO:0005737", "GO:0006914"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006914:autophagy:P"], "name": "Atg5", "pathway_ids": ["R-HSA-8934903", "R-DDI-1632852", "R-MMU-8934903", "R-RNO-8934903", "R-RNO-5205685", "R-CEL-8934903", "R-BTA-5205685", "R-CEL-1632852", "R-MMU-1632852", "R-HSA-936440", "R-CEL-5205685", "R-MMU-5205685", "R-BTA-1632852", "R-SCE-1632852", "R-SPO-8934903", "R-RNO-1632852", 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"R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-1632852:r:Macroautophagy"], "type": "Family"}, "IPR007240": {"description": "Autophagy-related protein 17", "go_ids": ["GO:0006914"], "go_terms": ["GO:0006914:autophagy:P"], "name": "Atg17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007241": {"description": "Autophagy-related protein 9", "go_ids": ["GO:0006914"], "go_terms": ["GO:0006914:autophagy:P"], "name": "Autophagy-rel_prot_9", "pathway_ids": ["R-SCE-1632852", "R-DDI-1632852", "R-RNO-1632852", "R-RNO-5205685", "R-BTA-5205685", "R-HSA-1632852", "R-MMU-1632852", "R-HSA-5205685", "R-MMU-5205685", "R-SPO-1632852", "R-BTA-1632852"], "pathways": ["R-SCE-1632852:r:Macroautophagy", "R-DDI-1632852:r:Macroautophagy", "R-RNO-1632852:r:Macroautophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-1632852:r:Macroautophagy", "R-BTA-1632852:r:Macroautophagy"], "type": "Family"}, "IPR007242": {"description": "Ubiquitin-like protein Atg12", "go_ids": ["GO:0000045", "GO:0005737"], "go_terms": ["GO:0000045:autophagosome assembly:P", "GO:0005737:cytoplasm:C"], "name": "Atg12", "pathway_ids": ["R-HSA-8934903", "R-DDI-1632852", "R-MMU-8934903", "R-RNO-5205685", "R-RNO-8934903", "R-CEL-8934903", "R-CEL-1632852", "R-MMU-1632852", "R-HSA-936440", "R-CEL-5205685", "R-MMU-5205685", "R-SCE-1632852", "R-SPO-8934903", "R-RNO-1632852", "R-SCE-8934903", "R-HSA-1632852", "R-DME-1632852", "R-HSA-5205685", "R-SPO-1632852"], "pathways": ["R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DDI-1632852:r:Macroautophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-CEL-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SCE-1632852:r:Macroautophagy", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-1632852:r:Macroautophagy", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-1632852:r:Macroautophagy"], "type": "Family"}, "IPR007243": {"description": "Atg6/Beclin", "go_ids": ["GO:0006914"], "go_terms": ["GO:0006914:autophagy:P"], "name": "Atg6/Beclin", "pathway_ids": ["R-DRE-5689880", "R-HSA-9694676", "R-DDI-1632852", "R-HSA-9705671", "R-BTA-5689880", "R-HSA-5689880", "R-MMU-1632852", "R-CEL-1632852", "R-RNO-1169408", "R-HSA-1169408", "R-MMU-1169408", "R-BTA-1632852", "R-RNO-5689880", "R-CEL-5689880", "R-MMU-5689880", "R-SCE-1632852", "R-HSA-983170", "R-CEL-1169408", "R-RNO-1632852", 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["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR007245": {"description": "GPI transamidase component PIG-T", "go_ids": ["GO:0042765", "GO:0016255"], "go_terms": ["GO:0042765:GPI-anchor transamidase complex:C", "GO:0016255:attachment of GPI anchor to protein:P"], "name": "PIG-T", "pathway_ids": ["R-MMU-162791", "R-HSA-162791"], "pathways": ["R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-HSA-162791:r:Attachment of GPI anchor to uPAR"], "type": "Family"}, "IPR007246": {"description": "GPI transamidase component Gaa1", "go_ids": ["GO:0016020", "GO:0042765"], "go_terms": ["GO:0016020:membrane:C", "GO:0042765:GPI-anchor transamidase complex:C"], "name": "Gaa1", "pathway_ids": ["R-MMU-162791", "R-HSA-162791"], "pathways": ["R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-HSA-162791:r:Attachment of GPI anchor to uPAR"], "type": "Family"}, "IPR007247": {"description": "Ureidoglycolate lyase", "go_ids": ["GO:0000256", "GO:0050385"], 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"R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR007253": {"description": "Cell wall binding repeat 2", "go_ids": [], "go_terms": [], "name": "Cell_wall-bd_2", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR007254": {"description": "Protein of unknown function DUF373", "go_ids": [], "go_terms": [], "name": "DUF373", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007255": {"description": "Conserved oligomeric Golgi complex subunit 8", "go_ids": ["GO:0017119"], "go_terms": ["GO:0017119:COG complex:C"], "name": "COG8", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-CEL-6811438", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Family"}, "IPR007256": {"description": "TM1367-like", "go_ids": [], "go_terms": [], "name": "TM1367-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007257": {"description": "DNA replication complex GINS protein Psf2", "go_ids": ["GO:0005634", "GO:0006260"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006260:DNA replication:P"], "name": "GINS_Psf2", "pathway_ids": ["R-CEL-176974", "R-DME-176974", "R-SPO-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974"], "pathways": ["R-CEL-176974:r:Unwinding of DNA", "R-DME-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA"], "type": "Family"}, "IPR007258": {"description": "Vps52", "go_ids": [], "go_terms": [], "name": "Vps52", "pathway_ids": 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"GO:0016020", "GO:0035434"], "go_terms": ["GO:0005375:copper ion transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0035434:copper ion transmembrane transport:P"], "name": "Cop_transporter", "pathway_ids": ["R-HSA-425410", "R-MMU-425410", "R-SCE-425410", "R-SPO-425410", "R-SSC-425410", "R-RNO-425410"], "pathways": ["R-HSA-425410:r:Metal ion SLC transporters", "R-MMU-425410:r:Metal ion SLC transporters", "R-SCE-425410:r:Metal ion SLC transporters", "R-SPO-425410:r:Metal ion SLC transporters", "R-SSC-425410:r:Metal ion SLC transporters", "R-RNO-425410:r:Metal ion SLC transporters"], "type": "Family"}, "IPR007275": {"description": "YTH domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "YTH_domain", "pathway_ids": ["R-MMU-9930044", "R-RNO-9930044", "R-HSA-9930044", "R-DME-9930044"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-RNO-9930044:r:Nuclear RNA decay", "R-HSA-9930044:r:Nuclear RNA decay", "R-DME-9930044:r:Nuclear RNA decay"], "type": "Domain"}, "IPR007276": {"description": "Nucleolar protein 14", "go_ids": ["GO:0032040"], "go_terms": ["GO:0032040:small-subunit processome:C"], "name": "Nop14", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR007277": {"description": "Svp26/Tex261", "go_ids": ["GO:0097020", "GO:0006888", "GO:0016020"], "go_terms": ["GO:0097020:COPII receptor activity:F", "GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P", "GO:0016020:membrane:C"], "name": "Svp26/Tex261", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007278": {"description": "Domain of unknown function DUF397", "go_ids": [], "go_terms": [], "name": "DUF397", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007280": {"description": "Peptidase, C-terminal, archaeal/bacterial", "go_ids": [], "go_terms": [], "name": "Peptidase_C_arc/bac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007281": {"description": "Mre11, DNA-binding", "go_ids": ["GO:0004519", "GO:0005634", "GO:0006302", "GO:0030145"], "go_terms": ["GO:0004519:endonuclease activity:F", "GO:0005634:nucleus:C", "GO:0006302:double-strand break repair:P", "GO:0030145:manganese ion binding:F"], "name": "Mre11_DNA-bd", "pathway_ids": ["R-HSA-5685942", "R-MMU-5693571", "R-HSA-5693616", "R-HSA-5693579", "R-MMU-1834949", "R-HSA-9704646", "R-RNO-5693565", "R-SCE-2559586", "R-MMU-6804756", "R-RNO-5685939", "R-HSA-5693565", "R-MMU-5693616", "R-RNO-5693548", "R-MMU-5685938", "R-MMU-5693565", "R-MMU-69473", "R-SCE-5693565", "R-HSA-9709570", "R-HSA-5693607", "R-GGA-351444", "R-RNO-5685938", "R-CEL-5685939", "R-HSA-912446", "R-HSA-1834949", "R-MMU-5685939", "R-SCE-5693548", "R-MMU-5693568", "R-RNO-6804756", "R-CEL-1834949", "R-MMU-5693579", "R-SPO-5685939", "R-GGA-351442", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-3270619", "R-CEL-5693548", "R-RNO-2559586", "R-MMU-5693548", "R-GGA-217106", "R-RNO-5693579", "R-HSA-69473", "R-MMU-2559586", "R-RNO-5693607", "R-HSA-9709603", "R-MMU-5685942", "R-SPO-5693565", "R-HSA-5685939", "R-RNO-5693571", "R-RNO-69473", "R-RNO-1834949", "R-RNO-5685942", "R-SCE-1834949", "R-HSA-5693571", "R-HSA-6804756", "R-SPO-2559586", "R-HSA-9704331", "R-RNO-5693568", "R-SPO-5693548", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-SPO-1834949", "R-HSA-2559586"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CEL-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-CEL-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-SCE-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Domain"}, "IPR007282": {"description": "NOT2/NOT3/NOT5, C-terminal", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "NOT2/3/5_C", "pathway_ids": ["R-MMU-6804115", "R-HSA-6804115", "R-MMU-429947", "R-HSA-429947", "R-HSA-9820841"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR007284": {"description": "Ground-like domain", "go_ids": [], "go_terms": [], "name": "Ground-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007287": {"description": "Sof1-like protein", "go_ids": [], "go_terms": [], "name": "Sof1", "pathway_ids": ["R-MMU-8951664", "R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-HSA-6791226", "R-HSA-8951664", "R-DDI-6791226", "R-DRE-8951664", "R-SPO-8951664", "R-XTR-8951664", "R-SPO-6791226", "R-HSA-6790901", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-8951664:r:Neddylation", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-XTR-8951664:r:Neddylation", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-8951664:r:Neddylation"], "type": "Domain"}, "IPR007288": {"description": "Influenzavirus B, glycoprotein NB", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "InfluenzaB_glycoprotein_NB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007289": {"description": "Jaagsiekte sheep retrovirus, Vpu", "go_ids": [], "go_terms": [], "name": "JSRV_Vpu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007290": {"description": "Arv1 protein", "go_ids": ["GO:0032366"], "go_terms": ["GO:0032366:intracellular sterol transport:P"], "name": "Arv1", "pathway_ids": ["R-HSA-191273", "R-DDI-191273", "R-SPO-191273", "R-SCE-191273", "R-MMU-191273"], "pathways": ["R-HSA-191273:r:Cholesterol biosynthesis", "R-DDI-191273:r:Cholesterol biosynthesis", "R-SPO-191273:r:Cholesterol biosynthesis", "R-SCE-191273:r:Cholesterol biosynthesis", "R-MMU-191273:r:Cholesterol biosynthesis"], "type": "Family"}, "IPR007291": {"description": "Capsid protein", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Capsid_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007292": {"description": "Nuclear fusion protein Kar5", "go_ids": ["GO:0000742", "GO:0048288"], "go_terms": ["GO:0000742:karyogamy involved in conjugation with cellular fusion:P", "GO:0048288:nuclear membrane fusion involved in karyogamy:P"], "name": "Nuclear_fusion_Kar5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007293": {"description": "Flagellar protein FlgP", "go_ids": [], "go_terms": [], "name": "FlgP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007294": {"description": "Protein of unknown function DUF401", "go_ids": [], "go_terms": [], "name": "DUF401", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007295": {"description": "Domain of unknown function DUF402", "go_ids": [], "go_terms": [], "name": "DUF402", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR007296": {"description": "Rv2567-like, DUF403", "go_ids": [], "go_terms": [], "name": "DUF403", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007298": {"description": "NlpE-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NlpE-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007300": {"description": "CidB/LrgB family", "go_ids": [], "go_terms": [], "name": "CidB/LrgB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007301": {"description": "TQO small subunit DoxD", "go_ids": [], "go_terms": [], "name": "DoxD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007302": {"description": "Circularly permuted ATPgrasp domain", "go_ids": [], "go_terms": [], "name": "CP_ATPgrasp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007303": {"description": "TIP41-like protein", "go_ids": [], "go_terms": [], "name": "TIP41-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007304": {"description": "TAP46-like protein", "go_ids": ["GO:0009966"], "go_terms": ["GO:0009966:regulation of signal transduction:P"], "name": "TAP46-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007305": {"description": "Vesicle transport protein, Got1/SFT2-like", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "Vesicle_transpt_Got1/SFT2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007306": {"description": "tRNA A64-2'-O-ribosylphosphate transferase", "go_ids": ["GO:0019988", "GO:0043399"], "go_terms": ["GO:0019988:charged-tRNA amino acid modification:P", "GO:0043399:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity:F"], "name": "Rit1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007307": {"description": "Low temperature viability protein Ltv1", "go_ids": ["GO:0042274"], "go_terms": ["GO:0042274:ribosomal small subunit biogenesis:P"], "name": "Ltv1", "pathway_ids": ["R-MMU-6791226", "R-RNO-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-SPO-6791226", "R-DDI-6791226", "R-DRE-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR007308": {"description": "Rtr1/RPAP2 domain", "go_ids": [], "go_terms": [], "name": "Rtr1/RPAP2_dom", "pathway_ids": ["R-SCE-6807505", "R-CEL-6807505", "R-HSA-6807505", "R-RNO-6807505", "R-MMU-6807505", "R-DRE-6807505"], "pathways": ["R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR007309": {"description": "B-block binding subunit of TFIIIC", "go_ids": [], "go_terms": [], "name": "TFIIIC_Bblock-bd", "pathway_ids": ["R-SCE-76066", "R-RNO-76061", "R-HSA-76066", "R-SPO-76066", "R-HSA-76061", "R-MMU-76061", "R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-RNO-76066", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR007310": {"description": "Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal", "go_ids": ["GO:0019290"], "go_terms": ["GO:0019290:siderophore biosynthetic process:P"], "name": "Aerobactin_biosyn_IucA/IucC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007311": {"description": "ST7", "go_ids": [], "go_terms": [], "name": "ST7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007312": {"description": "Phosphoesterase", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "Phosphoesterase", "pathway_ids": ["PWY-7782", "PWY-7783", "PWY-8052", "R-HSA-9636569", "R-HSA-9636383"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7783:t:plasmalogen degradation", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "R-HSA-9636569:r:Suppression of autophagy", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion"], "type": "Family"}, "IPR007313": {"description": "FxsA cytoplasmic membrane protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "FxsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007314": {"description": "Haem-binding uptake, Tiki superfamily, ChaN", "go_ids": [], "go_terms": [], "name": "Cofac_haem-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007315": {"description": "GPI mannosyltransferase 2", "go_ids": ["GO:0006506", "GO:0000009", "GO:0004376"], "go_terms": ["GO:0006506:GPI anchor biosynthetic process:P", "GO:0000009:alpha-1,6-mannosyltransferase activity:F", "GO:0004376:GPI mannosyltransferase activity:F"], "name": "PIG-V/Gpi18", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-SCE-162710", "R-DME-162710", "R-SPO-162710", "R-MMU-162710", "R-HSA-162710", "R-RNO-162710", "R-CEL-162710"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-DME-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-CEL-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR007317": {"description": "Golgi to ER traffic protein 4", "go_ids": ["GO:0045048"], "go_terms": ["GO:0045048:protein insertion into ER membrane:P"], "name": "GET4", "pathway_ids": ["R-HSA-9609523"], "pathways": ["R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Family"}, "IPR007318": {"description": "Phospholipid methyltransferase", "go_ids": [], "go_terms": [], "name": "Phopholipid_MeTrfase", "pathway_ids": ["PWY-6825", "R-HSA-1483191", "R-SCE-1483191", "R-BTA-1483191", "R-RNO-1483191", "R-DDI-1483191", "R-SPO-1483191", "R-MMU-1483191"], "pathways": ["PWY-6825:t:phosphatidylcholine biosynthesis V", "R-HSA-1483191:r:Synthesis of PC", "R-SCE-1483191:r:Synthesis of PC", "R-BTA-1483191:r:Synthesis of PC", "R-RNO-1483191:r:Synthesis of PC", "R-DDI-1483191:r:Synthesis of PC", "R-SPO-1483191:r:Synthesis of PC", "R-MMU-1483191:r:Synthesis of PC"], "type": "Domain"}, "IPR007319": {"description": "WDR36/Utp21, C-terminal domain", "go_ids": ["GO:0006364", "GO:0032040"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0032040:small-subunit processome:C"], "name": "WDR36/Utp21_C", "pathway_ids": ["R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR007320": {"description": "Programmed cell death protein 2, C-terminal", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "PDCD2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007321": {"description": "Transposase (putative), gypsy type", "go_ids": [], "go_terms": [], "name": "Transposase_28", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007322": {"description": "RNA-dependent RNA polymerase, bunyaviral", "go_ids": ["GO:0003968", "GO:0006351", "GO:0019079"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P", "GO:0019079:viral genome replication:P"], "name": "RNA_pol_bunyavir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007324": {"description": "Sugar-binding domain, putative", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "Sugar-bd_dom_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007325": {"description": "Kynurenine formamidase/cyclase-like", "go_ids": ["GO:0004061", "GO:0006569"], "go_terms": ["GO:0004061:arylformamidase activity:F", "GO:0006569:L-tryptophan catabolic process:P"], "name": "KFase/CYL", "pathway_ids": ["PWY-6309", "PWY-7717", "PWY-7734", "PWY-7765", "PWY-5651", "PWY-7733"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-5651:t:L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde", "PWY-7733:t:3-hydroxyquinaldate biosynthesis"], "type": "Family"}, "IPR007326": {"description": "Lipoprotein-associated domain", "go_ids": [], "go_terms": [], "name": "Lipoprotein-assoc_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007327": {"description": "Tumour protein D52", "go_ids": [], "go_terms": [], "name": "TPD52", "pathway_ids": ["R-HSA-432722", "R-CEL-432722", "R-MMU-432722"], "pathways": ["R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR007328": {"description": "Foot protein 3", "go_ids": [], "go_terms": [], "name": "Mfp-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007329": {"description": "FMN-binding", "go_ids": ["GO:0010181", "GO:0016020"], "go_terms": ["GO:0010181:FMN binding:F", "GO:0016020:membrane:C"], "name": "FMN-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007330": {"description": "MIT domain", "go_ids": [], "go_terms": [], "name": "MIT_dom", "pathway_ids": ["R-RNO-917729", "R-MMU-1474228", "R-HSA-1474228", "R-RNO-5632684", "R-HSA-9610379", "R-MMU-5632684", "R-MMU-917729", "R-MMU-9668328", "R-DME-9668328", "R-GGA-9668328", "R-HSA-162588", "R-HSA-5632684", "R-HSA-9668328", "R-HSA-917729", "R-SPO-9668328", "R-SCE-9668328", "R-BTA-9668328", "R-XTR-9668328", "R-DRE-9668328", "R-DDI-917729", "R-BTA-917729", "R-SSC-9668328", "R-DDI-9668328", "R-RNO-9668328"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-GGA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SCE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-BTA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-XTR-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DRE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SSC-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III"], "type": "Domain"}, "IPR007331": {"description": "Htaa", "go_ids": [], "go_terms": [], "name": "Htaa", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007332": {"description": "Protein of unknown function DUF411", "go_ids": [], "go_terms": [], "name": "DUF411", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007334": {"description": "Uncharacterised protein family UPF0208", "go_ids": [], "go_terms": [], "name": "UPF0208", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007335": {"description": "Protein of unknown function DUF413", "go_ids": [], "go_terms": [], "name": "DUF413", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007336": {"description": "Der GTPase-activating protein YihI", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "YihI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007337": {"description": "RelB antitoxin/Antitoxin DinJ", "go_ids": [], "go_terms": [], "name": "RelB/DinJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007338": {"description": "Protein of unknown function DUF416", "go_ids": [], "go_terms": [], "name": "DUF416", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007339": {"description": "Inner membrane protein RclC-like", "go_ids": [], "go_terms": [], "name": "RclC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007340": {"description": "Opacity-associated protein A, LysM-like domain", "go_ids": ["GO:0042834"], "go_terms": ["GO:0042834:peptidoglycan binding:F"], "name": "LysM_Opacity-associatedA", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR007341": {"description": "Transglycosylase-associated protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Transgly_assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007342": {"description": "Pseudouridine-5'-phosphate glycosidase", "go_ids": ["GO:0004730"], "go_terms": ["GO:0004730:pseudouridylate synthase activity:F"], "name": "PsuG", "pathway_ids": ["PWY-6019"], "pathways": ["PWY-6019:t:pseudouridine degradation"], "type": "Family"}, "IPR007343": {"description": "Uncharacterised protein family, zinc metallopeptidase putative", "go_ids": [], "go_terms": [], "name": "Uncharacterised_pept_Zn_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007344": {"description": "GrpB/Dephospho-CoA kinase", "go_ids": [], "go_terms": [], "name": "GrpB/CoaE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007345": {"description": "Polysaccharide pyruvyl transferase", "go_ids": [], "go_terms": [], "name": "Polysacch_pyruvyl_Trfase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007346": {"description": "Endonuclease I", "go_ids": ["GO:0004518"], "go_terms": ["GO:0004518:nuclease activity:F"], "name": "Endonuclease-I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007347": {"description": "Sporulation stage V, protein S", "go_ids": [], "go_terms": [], "name": "SpoVS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007348": {"description": "CopC domain", "go_ids": ["GO:0005507", "GO:0042597", "GO:0046688"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0042597:periplasmic space:C", "GO:0046688:response to copper ion:P"], "name": "CopC_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007349": {"description": "Domain of unknown function DUF418", "go_ids": [], "go_terms": [], "name": "DUF418", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007350": {"description": "Transposase, Tc5, C-terminal", "go_ids": [], "go_terms": [], "name": "Transposase_Tc5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007351": {"description": "YjbR", "go_ids": [], "go_terms": [], "name": "YjbR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007352": {"description": "Protein of unknown function DUF420", "go_ids": [], "go_terms": [], "name": "DUF420", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007353": {"description": "YetF, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF421", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007354": {"description": "Bisanhydrobacterioruberin hydratase CruF-like", "go_ids": [], "go_terms": [], "name": "CruF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007355": {"description": "Protein of unknown function DUF424", "go_ids": [], "go_terms": [], "name": "DUF424", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007356": {"description": "tRNA (guanine(9)-N1)-methyltransferase, eukaryotic", "go_ids": [], "go_terms": [], "name": "tRNA_m1G_MeTrfase_euk", "pathway_ids": ["R-HSA-6782315", "R-HSA-6785470", "R-HSA-8868766", "R-HSA-6787450"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6785470:r:tRNA processing in the mitochondrion", "R-HSA-8868766:r:rRNA processing in the mitochondrion", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Family"}, "IPR007357": {"description": "Photolyase PhrB-like", "go_ids": [], "go_terms": [], "name": "PhrB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007358": {"description": "Nucleoid-associated protein NdpA", "go_ids": ["GO:0009295"], "go_terms": ["GO:0009295:nucleoid:C"], "name": "Nucleoid_associated_NdpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007359": {"description": "Positive regulator of sigma(E), RseC/MucC", "go_ids": [], "go_terms": [], "name": "SigmaE_reg_RseC_MucC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007360": {"description": "Invasion gene expression up-regulator, SirB", "go_ids": [], "go_terms": [], "name": "SirB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007361": {"description": "Domain of unknown function DUF427", "go_ids": [], "go_terms": [], "name": "DUF427", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007362": {"description": "Protein of unknown function DUF429", "go_ids": [], "go_terms": [], "name": "DUF429", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007364": {"description": "Protein arginine N-methyltransferase SFM1-like", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "SFM1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007365": {"description": "Transferrin receptor-like, dimerisation domain", "go_ids": [], "go_terms": [], "name": "TFR-like_dimer_dom", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-MMU-8856828", "R-MMU-9013106", "R-HSA-8856828", "R-SSC-9013408", "R-MMU-9013408", "R-RNO-9013149", "R-SSC-9013026", "R-MMU-9013404", "R-SSC-917977", "R-SPO-9013106", "R-SSC-9013407", "R-SCE-8980692", "R-SPO-9696273", "R-RNO-9013408", "R-RNO-9013406", "R-HSA-9013408", "R-RNO-9013404", "R-SCE-9696273", "R-RNO-917977", "R-SSC-432722", "R-RNO-432722", "R-SCE-8963693", "R-MMU-9013407", "R-RNO-8963693", "R-HSA-8963693", "R-RNO-9013407", "R-SSC-9013406", "R-RNO-9696273", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-917977", "R-MMU-9013406", "R-SSC-9013149", "R-MMU-8963693", "R-HSA-9013026", "R-HSA-917977", "R-HSA-9013407", "R-SSC-9013148", "R-SSC-9696270", "R-HSA-9725554", "R-SSC-9013404", "R-MMU-8856825", "R-RNO-9696270", "R-MMU-8980692", "R-MMU-432722", "R-RNO-8980692", "R-HSA-9013106", "R-SSC-8980692", "R-SPO-9013406", "R-HSA-9013423", "R-SCE-9013406", "R-HSA-9013148", "R-SSC-8856825", "R-RNO-9013106", "R-RNO-8856828", "R-HSA-432722", "R-CEL-8963693", "R-SPO-8963693", "R-RNO-8856825", "R-HSA-9696270", "R-SSC-9696273", "R-SSC-9013423", "R-SCE-9013106", "R-RNO-9013423", "R-SSC-8856828", "R-HSA-8856825", "R-MMU-9013026", "R-SSC-9013106", "R-HSA-9013406", "R-MMU-9696270", "R-MMU-9696273", "R-MMU-9013149", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-9013408:r:RHOG GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-SSC-9013026:r:RHOB GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-SSC-917977:r:Transferrin endocytosis and recycling", "R-SPO-9013106:r:RHOC GTPase cycle", "R-SSC-9013407:r:RHOH GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-SCE-9696273:r:RND1 GTPase cycle", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SSC-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-SSC-9696270:r:RND2 GTPase cycle", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SSC-8980692:r:RHOA GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-SPO-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SSC-9696273:r:RND1 GTPase cycle", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR007366": {"description": "Protein of unknown function DUF432", "go_ids": [], "go_terms": [], "name": "DUF432", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007367": {"description": "VapB45-like, C-terminal", "go_ids": [], "go_terms": [], "name": "VapB45_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007368": {"description": "Domain of unknown function DUF434", "go_ids": [], "go_terms": [], "name": "DUF434", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007369": {"description": "Peptidase A22B, signal peptide peptidase", "go_ids": ["GO:0016020", "GO:0042500"], "go_terms": ["GO:0016020:membrane:C", "GO:0042500:aspartic endopeptidase activity, intramembrane cleaving:F"], "name": "Peptidase_A22B_SPP", "pathway_ids": ["R-RNO-5357905", "R-HSA-5357905", "R-MMU-9707587", "R-HSA-9707587", "R-MMU-5357905"], "pathways": ["R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9707587:r:Regulation of HMOX1 expression and activity", "R-HSA-9707587:r:Regulation of HMOX1 expression and activity", "R-MMU-5357905:r:Regulation of TNFR1 signaling"], "type": "Family"}, "IPR007370": {"description": "Glutamate--cysteine ligase", "go_ids": ["GO:0004357", "GO:0006750"], "go_terms": ["GO:0004357:glutamate-cysteine ligase activity:F", "GO:0006750:glutathione biosynthetic process:P"], "name": "Glu_cys_ligase", "pathway_ids": ["PWY-8043", "PWY-6840", "PWY-7255"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "PWY-6840:t:homoglutathione biosynthesis", "PWY-7255:t:ergothioneine biosynthesis I (bacteria)"], "type": "Domain"}, "IPR007371": {"description": "Thiamin pyrophosphokinase, catalytic domain", "go_ids": ["GO:0004788", "GO:0005524", "GO:0009229"], "go_terms": ["GO:0004788:thiamine diphosphokinase activity:F", "GO:0005524:ATP binding:F", "GO:0009229:thiamine diphosphate biosynthetic process:P"], "name": "TPK_catalytic", "pathway_ids": ["PWY-6898", "PWY-6908", "PWY-6907", "PWY-7356", "R-HSA-196819", "R-BTA-196819", "R-SPO-196819", "R-SCE-196819", "R-CEL-196819", "R-MMU-196819"], "pathways": ["PWY-6898:t:thiamine diphosphate salvage III", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism", "R-SPO-196819:r:Vitamin B1 (thiamin) metabolism", "R-SCE-196819:r:Vitamin B1 (thiamin) metabolism", "R-CEL-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Domain"}, "IPR007372": {"description": "Lipid/polyisoprenoid-binding, YceI-like", "go_ids": [], "go_terms": [], "name": "Lipid/polyisoprenoid-bd_YceI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007373": {"description": "Thiamin pyrophosphokinase, thiamin-binding domain", "go_ids": ["GO:0009229", "GO:0030975"], "go_terms": ["GO:0009229:thiamine diphosphate biosynthetic process:P", "GO:0030975:thiamine binding:F"], "name": "Thiamin_PyroPKinase_B1-bd", "pathway_ids": ["PWY-6898", "PWY-6908", "PWY-6907", "PWY-7356", "R-HSA-196819", "R-BTA-196819", "R-SPO-196819", "R-SCE-196819", "R-CEL-196819", "R-MMU-196819"], "pathways": ["PWY-6898:t:thiamine diphosphate salvage III", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism", "R-SPO-196819:r:Vitamin B1 (thiamin) metabolism", "R-SCE-196819:r:Vitamin B1 (thiamin) metabolism", "R-CEL-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Domain"}, "IPR007374": {"description": "ASCH domain", "go_ids": [], "go_terms": [], "name": "ASCH_dom", "pathway_ids": ["R-MMU-9954716", "R-HSA-9954716"], "pathways": ["R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "type": "Domain"}, "IPR007375": {"description": "Sarcosine oxidase, gamma subunit", "go_ids": [], "go_terms": [], "name": "SoxG", "pathway_ids": ["PWY-3661"], "pathways": ["PWY-3661:t:glycine betaine degradation I"], "type": "Family"}, "IPR007376": {"description": "dsDNA mimic, putative", "go_ids": [], "go_terms": [], "name": "dsDNA_mimic_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007378": {"description": "Tic22-like", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "Tic22-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007379": {"description": "Tim44-like domain", "go_ids": [], "go_terms": [], "name": "Tim44-like_dom", "pathway_ids": ["R-CEL-9937383", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-CEL-5389840", "R-HSA-1268020", "R-MMU-5419276", "R-XTR-5419276", "R-XTR-5389840", "R-CEL-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-DME-5419276", "R-DME-5389840", "R-MMU-5389840", "R-DME-9937383", "R-XTR-9937383"], "pathways": ["R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-5419276:r:Mitochondrial translation termination", "R-XTR-5419276:r:Mitochondrial translation termination", "R-XTR-5389840:r:Mitochondrial translation elongation", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DME-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-XTR-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Domain"}, "IPR007380": {"description": "Domain of unknown function DUF438", "go_ids": [], "go_terms": [], "name": "DUF438", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007381": {"description": "Taxis protein CheF1/F2", "go_ids": ["GO:0006935"], "go_terms": ["GO:0006935:chemotaxis:P"], "name": "CheF1/F2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007382": {"description": "Uncharacterised protein family UPF0756, transmembrame", "go_ids": [], "go_terms": [], "name": "UPF0756_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007383": {"description": "Protein of unknown function DUF445", "go_ids": [], "go_terms": [], "name": "DUF445", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007384": {"description": "Protein of unknown function UCP006257", "go_ids": [], "go_terms": [], "name": "UCP006257", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007385": {"description": "Prokaryotic chromosome segregation/condensation protein MukE", "go_ids": ["GO:0005737", "GO:0007059", "GO:0030261"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0007059:chromosome segregation:P", "GO:0030261:chromosome condensation:P"], "name": "Scp_MukE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007386": {"description": "DUF447, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF447_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007387": {"description": "TRAP transporter, small membrane protein DctQ", "go_ids": [], "go_terms": [], "name": "TRAP_DctQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007390": {"description": "Sporulation stage V, protein R", "go_ids": [], "go_terms": [], "name": "Spore_V_R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007391": {"description": "Vancomycin resistance VanW", "go_ids": [], "go_terms": [], "name": "Vancomycin_resist_VanW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007392": {"description": "D-galactarate/Altronate dehydratase, second domain", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "GD_AH_second", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007393": {"description": "YlxR domain", "go_ids": [], "go_terms": [], "name": "YlxR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007394": {"description": "YlxM-like", "go_ids": [], "go_terms": [], "name": "UPF0122", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007395": {"description": "Putative neutral zinc metallopeptidase", "go_ids": [], "go_terms": [], "name": "Zn_peptidase_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007396": {"description": "Transcriptional regulator PAI 2-type", "go_ids": [], "go_terms": [], "name": "TR_PAI2-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007397": {"description": "F-box associated (FBA) domain", "go_ids": [], "go_terms": [], "name": "F-box-assoc_dom", "pathway_ids": ["R-BTA-983168", "R-MMU-8951664", "R-BTA-8951664", "R-HSA-390471", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR007398": {"description": "Pimeloyl-ACP methyl esterase BioG", "go_ids": [], "go_terms": [], "name": "BioG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007400": {"description": "PrpF-like", "go_ids": [], "go_terms": [], "name": "PrpF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007401": {"description": "Protein of unknown function DUF454", "go_ids": [], "go_terms": [], "name": "DUF454", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007402": {"description": "Protein of unknown function DUF455", "go_ids": [], "go_terms": [], "name": "DUF455", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007403": {"description": "Protein of unknown function DUF456", "go_ids": [], "go_terms": [], "name": "DUF456", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007404": {"description": "YdjM inner membrane, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YdjM-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007405": {"description": "Bacteriophage KVP40, Orf299", "go_ids": [], "go_terms": [], "name": "Phage_KVP40_Orf299", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007406": {"description": "MukB, N-terminal domain", "go_ids": ["GO:0005524", "GO:0007059", "GO:0009295", "GO:0030261", "GO:0003677"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0007059:chromosome segregation:P", "GO:0009295:nucleoid:C", "GO:0030261:chromosome condensation:P", "GO:0003677:DNA binding:F"], "name": "MukB_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007407": {"description": "Protein of unknown function DUF459", "go_ids": [], "go_terms": [], "name": "DUF459", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007408": {"description": "Protein of unknown function DUF460", "go_ids": [], "go_terms": [], "name": "DUF460", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007409": {"description": "Restriction endonuclease, type I, HsdR, N-terminal", "go_ids": ["GO:0003677", "GO:0004519", "GO:0006304"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004519:endonuclease activity:F", "GO:0006304:DNA modification:P"], "name": "Restrct_endonuc_type1_HsdR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007410": {"description": "Putative lipoprotein LpqE-like", "go_ids": [], "go_terms": [], "name": "LpqE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007411": {"description": "Elongation factor P hydroxylase", "go_ids": [], "go_terms": [], "name": "EpmC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007412": {"description": "Anti-sigma-28 factor, FlgM", "go_ids": ["GO:0045892"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "FlgM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007413": {"description": "Ras-like GTPase YcjX", "go_ids": [], "go_terms": [], "name": "YcjX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007414": {"description": "Protein of unknown function DUF468", "go_ids": [], "go_terms": [], "name": "DUF468", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007415": {"description": "Nitrogenase MoFe maturation protein, NifZ", "go_ids": ["GO:0009399"], "go_terms": ["GO:0009399:nitrogen fixation:P"], "name": "Nitrogenase_MoFe_mat_NifZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007416": {"description": "YggL 50S ribosome-binding protein", "go_ids": [], "go_terms": [], "name": "YggL_50S_bp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007417": {"description": "Protein of unknown function DUF473", "go_ids": [], "go_terms": [], "name": "DUF473", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007418": {"description": "Protein of unknown function DUF474", "go_ids": [], "go_terms": [], "name": "DUF474", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007419": {"description": "BFD-like [2Fe-2S]-binding domain", "go_ids": [], "go_terms": [], "name": "BFD-like_2Fe2S-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007420": {"description": "Protein of unknown function DUF465", "go_ids": [], "go_terms": [], "name": "DUF465", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007421": {"description": "Schlafen, AlbA_2 domain", "go_ids": [], "go_terms": [], "name": "Schlafen_AlbA_2_dom", "pathway_ids": ["R-CEL-9770562", "R-CEL-72163", "R-CEL-72203"], "pathways": ["R-CEL-9770562:r:mRNA Polyadenylation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Domain"}, "IPR007422": {"description": "Cysteine protease Prp", "go_ids": [], "go_terms": [], "name": "Peptidase_Prp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007423": {"description": "Selenoprotein, putative", "go_ids": [], "go_terms": [], "name": "Sel_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007427": {"description": "Protein of unknown function DUF475", "go_ids": [], "go_terms": [], "name": "DUF475", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007428": {"description": "MlaA lipoprotein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "MlaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007429": {"description": "Protein of unknown function DUF478", "go_ids": [], "go_terms": [], "name": "DUF478", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007430": {"description": "Bacterial virulence protein VirB8-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "VirB8-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007431": {"description": "Acyl carrier protein phosphodiesterase", "go_ids": ["GO:0006633", "GO:0008770"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P", "GO:0008770:[acyl-carrier-protein] phosphodiesterase activity:F"], "name": "ACP_PD", "pathway_ids": ["PWY-6012"], "pathways": ["PWY-6012:t:acyl carrier protein metabolism"], "type": "Family"}, "IPR007432": {"description": "Protein of unknown function DUF480", "go_ids": [], "go_terms": [], "name": "DUF480", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007433": {"description": "Protein of unknown function DUF481", "go_ids": [], "go_terms": [], "name": "DUF481", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007434": {"description": "Peptidogalycan biosysnthesis/recognition", "go_ids": [], "go_terms": [], "name": "FemAB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007435": {"description": "Protein of unknown function DUF484", "go_ids": [], "go_terms": [], "name": "DUF484", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007436": {"description": "Protein of unknown function DUF485", "go_ids": [], "go_terms": [], "name": "DUF485", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007437": {"description": "Protein of unknown function DUF486", "go_ids": [], "go_terms": [], "name": "DUF486", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007438": {"description": "Protein of unknown function DUF488", "go_ids": [], "go_terms": [], "name": "DUF488", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007439": {"description": "Chemotaxis phosphatase, CheZ", "go_ids": ["GO:0003824", "GO:0009288", "GO:0050920"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0009288:bacterial-type flagellum:C", "GO:0050920:regulation of chemotaxis:P"], "name": "Chemotax_Pase_CheZ", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR007440": {"description": "Chorismate--pyruvate lyase", "go_ids": ["GO:0005737", "GO:0006744", "GO:0008813"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006744:ubiquinone biosynthetic process:P", "GO:0008813:chorismate lyase activity:F"], "name": "Chorismate--pyruvate_lyase", "pathway_ids": ["PWY-5870", "PWY-7934", "PWY-5755", "PWY-7935", "PWY-7742", "PWY-6148", "PWY-7929", "PWY-7745"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-7934:t:polybrominated dihydroxylated diphenyl ethers biosynthesis", "PWY-5755:t:4-hydroxybenzoate biosynthesis II (bacteria)", "PWY-7935:t:spongiadioxin C biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-7929:t:polybrominated phenols biosynthesis", "PWY-7745:t:p-HBAD biosynthesis"], "type": "Family"}, "IPR007441": {"description": "Ethanolamine utilisation protein EutH", "go_ids": ["GO:0016020", "GO:0034229", "GO:0034228"], "go_terms": ["GO:0016020:membrane:C", "GO:0034229:ethanolamine transport:P", "GO:0034228:ethanolamine transmembrane transporter activity:F"], "name": "EutH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007443": {"description": "Penicillin-binding protein activator LpoA", "go_ids": [], "go_terms": [], "name": "LpoA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007444": {"description": "Glucan biosynthesis, periplasmic, MdoG C-terminal", "go_ids": ["GO:0016051", "GO:0042597"], "go_terms": ["GO:0016051:carbohydrate biosynthetic process:P", "GO:0042597:periplasmic space:C"], "name": "Glucan_biosyn_MdoG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007445": {"description": "Type IV pilus inner membrane component PilO", "go_ids": ["GO:0043683", "GO:0043107"], "go_terms": ["GO:0043683:type IV pilus assembly:P", "GO:0043107:type IV pilus-dependent motility:P"], "name": "PilO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007446": {"description": "Type IV pilus inner membrane component PilP", "go_ids": [], "go_terms": [], "name": "PilP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007448": {"description": "Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Sigma70_reg_Rsd_AlgQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007449": {"description": "ZipA, C-terminal FtsZ-binding domain", "go_ids": ["GO:0090529"], "go_terms": ["GO:0090529:cell septum assembly:P"], "name": "ZipA_FtsZ-bd_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007450": {"description": "Outer membrane protein assembly factor BamE domain", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "BamE_dom", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR007451": {"description": "High frequency lysogenization protein HflD", "go_ids": [], "go_terms": [], "name": "HflD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007452": {"description": "Translocation and assembly module TamB, C-terminal domain", "go_ids": ["GO:0005886", "GO:0009306"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0009306:protein secretion:P"], "name": "TamB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007453": {"description": "Sulphur transfer protein DsrC/TusE", "go_ids": [], "go_terms": [], "name": "DsrC/TusE", "pathway_ids": ["PWY-7889", "PWY-7888", "PWY-6892", "PWY-5303", "PWY-7904", "PWY-7250", "PWY-7892", "PWY-8164", "PWY-6675", "PWY-8179", "PWY-7891", "PWY-7887"], "pathways": ["PWY-7889:t:tRNA-uridine 2-thiolation (mammalian mitochondria)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6892:t:thiazole component of thiamine diphosphate biosynthesis I", "PWY-5303:t:thiosulfate oxidation II (via tetrathionate)", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-8164:t:bis(guanylyl molybdopterin) cofactor sulfurylation", "PWY-6675:t:sulfur oxidation IV (intracellular sulfur)", "PWY-8179:t:platensimycin biosynthesis", "PWY-7891:t:tRNA-uridine 2-thiolation (yeast mitochondria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation"], "type": "Family"}, "IPR007454": {"description": "Uncharacterised protein family UPF0250, YbeD-like", "go_ids": [], "go_terms": [], "name": "UPF0250_YbeD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007455": {"description": "Serglycin", "go_ids": [], "go_terms": [], "name": "Serglycin", "pathway_ids": ["R-HSA-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR007456": {"description": "Smg", "go_ids": [], "go_terms": [], "name": "Smg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007457": {"description": "Fe(II) trafficking protein YggX", "go_ids": ["GO:0005506"], "go_terms": ["GO:0005506:iron ion binding:F"], "name": "Fe_traffick_prot_YggX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007458": {"description": "Protein of unknown function DUF496", "go_ids": [], "go_terms": [], "name": "DUF496", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007459": {"description": "DNA polymerase III chi subunit, HolC", "go_ids": ["GO:0003677", "GO:0003887", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P"], "name": "DNA_pol3_chi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007460": {"description": "Ribonuclease toxin, BrnT, of type II toxin-antitoxin system", "go_ids": [], "go_terms": [], "name": "BrnT_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007461": {"description": "Ysc84 actin-binding domain", "go_ids": [], "go_terms": [], "name": "Ysc84_actin-binding", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007462": {"description": "Protein CONTINUOUS VASCULAR RING 1-like", "go_ids": [], "go_terms": [], "name": "COV1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007463": {"description": "Protein of unknown function DUF507", "go_ids": [], "go_terms": [], "name": "DUF507", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007464": {"description": "Bacteriocin, class IId", "go_ids": ["GO:0005576", "GO:0042742"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042742:defense response to bacterium:P"], "name": "Bacteriocin_IId", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007465": {"description": "Domain of unknown function DUF508", "go_ids": [], "go_terms": [], "name": "DUF508", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007466": {"description": "Peptidyl-arginine deiminase, Porphyromonas-type", "go_ids": ["GO:0009446", "GO:0004668"], "go_terms": ["GO:0009446:putrescine biosynthetic process:P", "GO:0004668:protein-arginine deiminase activity:F"], "name": "Peptidyl-Arg-deiminase_porph", "pathway_ids": ["PWY-43"], "pathways": ["PWY-43:t:putrescine biosynthesis II"], "type": "Family"}, "IPR007470": {"description": "Putative uroporphyrinogen-III C-methyltransferase HemX", "go_ids": [], "go_terms": [], "name": "HemX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007471": {"description": "N-end aminoacyl transferase, N-terminal", "go_ids": ["GO:0004057", "GO:0016598"], "go_terms": ["GO:0004057:arginyl-tRNA--protein transferase activity:F", "GO:0016598:protein arginylation:P"], "name": "N-end_Aminoacyl_Trfase_N", "pathway_ids": ["PWY-7802"], "pathways": ["PWY-7802:t:N-end rule pathway II (prokaryotic)"], "type": "Domain"}, "IPR007472": {"description": "N-end rule aminoacyl transferase, C-terminal", "go_ids": ["GO:0004057", "GO:0016598"], "go_terms": ["GO:0004057:arginyl-tRNA--protein transferase activity:F", "GO:0016598:protein arginylation:P"], "name": "N-end_Aminoacyl_Trfase_C", "pathway_ids": ["PWY-7802"], "pathways": ["PWY-7802:t:N-end rule pathway II (prokaryotic)"], "type": "Domain"}, "IPR007473": {"description": "Ribosomal RNA large subunit methyltransferase J", "go_ids": ["GO:0070475", "GO:0008649"], "go_terms": ["GO:0070475:rRNA base methylation:P", "GO:0008649:rRNA methyltransferase activity:F"], "name": "RlmJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007474": {"description": "ApaG domain", "go_ids": [], "go_terms": [], "name": "ApaG_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007475": {"description": "Ubiquinone biosynthesis accessory factor UbiK", "go_ids": [], "go_terms": [], "name": "UbiK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007476": {"description": "Putative exonuclease, RdgC", "go_ids": ["GO:0006310"], "go_terms": ["GO:0006310:DNA recombination:P"], "name": "RdgC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007477": {"description": "SAB domain", "go_ids": ["GO:0005856", "GO:0008092", "GO:0030866"], "go_terms": ["GO:0005856:cytoskeleton:C", "GO:0008092:cytoskeletal protein binding:F", "GO:0030866:cortical actin cytoskeleton organization:P"], "name": "SAB_dom", "pathway_ids": ["R-HSA-399719", "R-BTA-6794361", "R-HSA-9662360", "R-HSA-9662361", "R-MMU-6794361", "R-RNO-6794361", "R-RNO-399719", "R-MMU-399719", "R-HSA-6794361"], "pathways": ["R-HSA-399719:r:Trafficking of AMPA receptors", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-HSA-6794361:r:Neurexins and neuroligins"], "type": "Domain"}, "IPR007479": {"description": "ISC system FeS cluster assembly, IscX", "go_ids": ["GO:0016226"], "go_terms": ["GO:0016226:iron-sulfur cluster assembly:P"], "name": "ISC_FeS_clus_asmbl_IscsX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007480": {"description": "Protein of unknown function DUF529", "go_ids": [], "go_terms": [], "name": "DUF529", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR007481": {"description": "Stringent starvation protein B", "go_ids": [], "go_terms": [], "name": "SspB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007482": {"description": "Protein-tyrosine phosphatase-like, PTPLA", "go_ids": [], "go_terms": [], "name": "Tyr_Pase-like_PTPLA", "pathway_ids": ["PWY-5080", "PWY-7053", "PWY-7035", "PWY-7036", "PWY-7727", "PWY-8041", "PWY-6433", "PWY-6958", "PWY-6598", "PWY-7726", "PWY-7619", "PWY-7049", "PWY-5353", "PWY-7601", "PWY-7728", "PWY-7602", "PWY-7724", "PWY-7606", "PWY-7592", "PWY-7725", "R-SCE-75876", "R-CEL-75876", "R-DRE-75876", "R-BTA-75876", "R-MMU-75876", "R-SPO-75876", "R-HSA-75876"], "pathways": ["PWY-5080:t:very long chain fatty acid biosynthesis I", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7035:t:(9Z)-tricosene biosynthesis", "PWY-7036:t:very long chain fatty acid biosynthesis II", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8041:t:ultra-long-chain fatty acid biosynthesis", "PWY-6433:t:hydroxylated fatty acid biosynthesis (plants)", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-6598:t:sciadonate biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-7619:t:juniperonate biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-7724:t:icosapentaenoate biosynthesis III (8-desaturase, mammals)", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7725:t:arachidonate biosynthesis V (8-detaturase, mammals)", "R-SCE-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-CEL-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-DRE-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-SPO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs"], "type": "Family"}, "IPR007483": {"description": "Hamartin", "go_ids": [], "go_terms": [], "name": "Hamartin", "pathway_ids": ["R-RNO-8854214", "R-RNO-1632852", "R-MMU-165181", "R-HSA-8854214", "R-MMU-380972", "R-SPO-5628897", "R-RNO-380972", "R-SPO-380972", "R-HSA-1632852", "R-MMU-1632852", "R-MMU-5628897", "R-SPO-165181", "R-RNO-5628897", "R-RNO-165181", "R-HSA-165181", "R-MMU-8854214", "R-HSA-5628897", "R-HSA-380972"], "pathways": ["R-RNO-8854214:r:TBC/RABGAPs", "R-RNO-1632852:r:Macroautophagy", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-MMU-8854214:r:TBC/RABGAPs", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK"], "type": "Family"}, "IPR007484": {"description": "Peptidase M28", "go_ids": [], "go_terms": [], "name": "Peptidase_M28", "pathway_ids": ["R-HSA-9013407", "R-SSC-9013148", "R-SSC-9696270", "R-HSA-9725554", "R-SSC-9013404", "R-MMU-8856825", "R-RNO-9696270", "R-MMU-8980692", "R-MMU-432722", "R-SCE-6798695", "R-RNO-8980692", "R-HSA-9013106", "R-SSC-8980692", "R-SPO-9013406", "R-HSA-9013423", "R-SCE-9013406", "R-HSA-9013148", "R-SSC-8856825", "R-RNO-9013106", "R-RNO-8856828", "R-HSA-432722", "R-CEL-8963693", "R-SPO-8963693", "R-RNO-8856825", "R-HSA-9696270", "R-DME-6798695", "R-SSC-9696273", "R-SSC-9013423", "R-SCE-9013106", "R-RNO-9013423", "R-SSC-8856828", "R-HSA-8856825", "R-MMU-9013026", "R-SSC-9013106", "R-HSA-9013406", "R-MMU-9696270", "R-MMU-9696273", "R-MMU-9013149", "R-HSA-9696273", "R-RNO-9013026", "R-HSA-9013409", "R-HSA-6798695", "R-MMU-8856828", "R-MMU-9013106", "R-HSA-8856828", "R-SSC-9013408", "R-MMU-9013408", "R-RNO-9013149", "R-SSC-9013026", "R-MMU-9013404", "R-SSC-917977", "R-SPO-9013106", "R-SSC-9013407", "R-SCE-8980692", "R-SPO-9696273", "R-RNO-9013408", "R-RNO-9013406", "R-HSA-9013408", "R-RNO-9013404", "R-SCE-9696273", "R-RNO-917977", "R-SSC-432722", "R-RNO-432722", "R-SCE-8963693", "R-DDI-6798695", "R-MMU-9013407", "R-RNO-8963693", "R-HSA-8963693", "R-RNO-9013407", "R-SSC-9013406", "R-RNO-9696273", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-917977", "R-MMU-9013406", "R-SSC-9013149", "R-MMU-8963693", "R-HSA-9013026", "R-MMU-6798695", "R-HSA-917977"], "pathways": ["R-HSA-9013407:r:RHOH GTPase cycle", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-SSC-9696270:r:RND2 GTPase cycle", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SSC-8980692:r:RHOA GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-SPO-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-SSC-9696273:r:RND1 GTPase cycle", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-9013408:r:RHOG GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-SSC-9013026:r:RHOB GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-SSC-917977:r:Transferrin endocytosis and recycling", "R-SPO-9013106:r:RHOC GTPase cycle", "R-SSC-9013407:r:RHOH GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-SCE-9696273:r:RND1 GTPase cycle", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SSC-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-917977:r:Transferrin endocytosis and recycling"], "type": "Domain"}, "IPR007485": {"description": "LPS-assembly lipoprotein LptE", "go_ids": ["GO:0043165", "GO:0019867"], "go_terms": ["GO:0043165:Gram-negative-bacterium-type cell outer membrane assembly:P", "GO:0019867:outer membrane:C"], "name": "LPS_assembly_LptE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007486": {"description": "Inner membrane protein YebE", "go_ids": [], "go_terms": [], "name": "YebE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007487": {"description": "ABC transporter, tyrosine-binding protein-like", "go_ids": [], "go_terms": [], "name": "ABC_transpt-TYRBP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007488": {"description": "Protein of unknown function DUF535", "go_ids": [], "go_terms": [], "name": "DUF535", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007489": {"description": "Regulator of chromosome segregation-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RocS-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007490": {"description": "Poxvirus B22, central", "go_ids": [], "go_terms": [], "name": "Poxvirus_B22_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007492": {"description": "LytTR DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "LytTR_DNA-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007493": {"description": "Protein of unknown function DUF538", "go_ids": [], "go_terms": [], "name": "DUF538", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007494": {"description": "Glutaredoxin 2, C-terminal", "go_ids": [], "go_terms": [], "name": "Glutaredoxin2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007495": {"description": "(Na+)-NQR maturation factor NqrM", "go_ids": [], "go_terms": [], "name": "NqrM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007497": {"description": "Interleukin-1 receptor-associated kinase 1-binding protein 1/DUF541", "go_ids": [], "go_terms": [], "name": "SIMPL/DUF541", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007498": {"description": "Intermembrane transport protein PqiA-like", "go_ids": [], "go_terms": [], "name": "PqiA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007499": {"description": "Essential recombination function protein", "go_ids": [], "go_terms": [], "name": "ERF_bacteria_virus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007501": {"description": "Protein of unknown function DUF531", "go_ids": [], "go_terms": [], "name": "DUF531", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007502": {"description": "Helicase-associated domain", "go_ids": [], "go_terms": [], "name": "Helicase-assoc_dom", "pathway_ids": ["R-CEL-3134963", "R-HSA-9930044", "R-HSA-9833482", "R-MMU-9770562", "R-DME-1810476", "R-DME-6791226", "R-HSA-73856", "R-DME-72163", "R-DDI-9770562", "R-CEL-73856", "R-HSA-72187", "R-RNO-3134963", "R-MMU-3134963", "R-DDI-72163", "R-HSA-6790901", "R-DME-9770562", "R-MMU-9833482", "R-HSA-3134963", "R-SCE-6791226", "R-CEL-9770562", "R-MMU-1810476", "R-CEL-6791226", "R-BTA-3134963", "R-CEL-72163", "R-HSA-9918481", "R-HSA-5601884", "R-BTA-72163", "R-MMU-9930044", "R-HSA-9770562", "R-MMU-72163", "R-BTA-73856", "R-CEL-9833482", "R-DME-9833482", "R-HSA-1810476", "R-SPO-9770562", "R-HSA-72163", "R-BTA-1810476", "R-HSA-6791226", "R-BTA-9770562", "R-BTA-159236", "R-HSA-159236", "R-SPO-72163", "R-SPO-6791226", "R-BTA-9833482", "R-DME-3134963", "R-CEL-159236"], "pathways": ["R-CEL-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-9770562:r:mRNA Polyadenylation", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-9833482:r:PKR-mediated signaling", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9833482:r:PKR-mediated signaling", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR007503": {"description": "Protein of unknown function DUF530", "go_ids": [], "go_terms": [], "name": "DUF530", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007504": {"description": "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1", "go_ids": ["GO:0042254", "GO:0001522"], "go_terms": ["GO:0042254:ribosome biogenesis:P", "GO:0001522:pseudouridine synthesis:P"], "name": "H/ACA_rnp_Gar1/Naf1", "pathway_ids": ["R-XTR-171319", "R-DRE-171319", "R-RNO-171319", "R-HSA-6790901", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-XTR-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Family"}, "IPR007505": {"description": "PD-(D/E)XK nuclease superfamily 7", "go_ids": [], "go_terms": [], "name": "PDDEXK_7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007507": {"description": "3-deoxy-D-manno-octulosonic-acid transferase, N-terminal", "go_ids": [], "go_terms": [], "name": "Glycos_transf_N", "pathway_ids": ["PWY-8074", "PWY-8246", "PWY-8284", "PWY-7675"], "pathways": ["PWY-8074:t:Kdo transfer to lipid IVA (P. putida)", "PWY-8246:t:Kdo transfer to lipid IVA (P. gingivalis)", "PWY-8284:t:Kdo transfer to lipid IVA (Vibrio cholerae serogroup O1 El Tor)", "PWY-7675:t:Kdo transfer to lipid IVA (Haemophilus)"], "type": "Domain"}, "IPR007508": {"description": "D-aminoacyl-tRNA deacylase DtdA", "go_ids": ["GO:0016788", "GO:0051499"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F", "GO:0051499:D-aminoacyl-tRNA deacylase activity:F"], "name": "DtdA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007509": {"description": "Protein of unknown function DUF515", "go_ids": [], "go_terms": [], "name": "DUF515", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007511": {"description": "Protein of unknown function DUF501", "go_ids": [], "go_terms": [], "name": "DUF501", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007512": {"description": "MICOS complex subunit Mic10", "go_ids": ["GO:0061617", "GO:0005743"], "go_terms": ["GO:0061617:MICOS complex:C", "GO:0005743:mitochondrial inner membrane:C"], "name": "Mic10", "pathway_ids": ["R-HSA-8949613"], "pathways": ["R-HSA-8949613:r:Cristae formation"], "type": "Family"}, "IPR007513": {"description": "Small EDRK-rich factor-like, N-terminal", "go_ids": [], "go_terms": [], "name": "SERF-like_N", "pathway_ids": ["R-MMU-212436", "R-HSA-212436", "R-GGA-212436"], "pathways": ["R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway", "R-GGA-212436:r:Generic Transcription Pathway"], "type": "Domain"}, "IPR007515": {"description": "Mss4", "go_ids": ["GO:0005085", "GO:0007264"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0007264:small GTPase-mediated signal transduction:P"], "name": "Mss4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007516": {"description": "Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "Co_F420_Hydgase/DH_bsu_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007518": {"description": "MINDY deubiquitinase", "go_ids": ["GO:1990380", "GO:0004843"], "go_terms": ["GO:1990380:K48-linked deubiquitinase activity:F", "GO:0004843:cysteine-type deubiquitinase activity:F"], "name": "MINDY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007519": {"description": "Bul1, N-terminal", "go_ids": [], "go_terms": [], "name": "Bul1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007521": {"description": "Choline kinase, N-terminal", "go_ids": ["GO:0016773"], "go_terms": ["GO:0016773:phosphotransferase activity, alcohol group as acceptor:F"], "name": "Choline_kin_N", "pathway_ids": ["PWY-7782", "PWY-7818", "PWY-7886", "R-SPO-1483191", "R-SCE-1483191", "R-SCE-1483213", "R-SPO-1483213"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "R-SPO-1483191:r:Synthesis of PC", "R-SCE-1483191:r:Synthesis of PC", "R-SCE-1483213:r:Synthesis of PE", "R-SPO-1483213:r:Synthesis of PE"], "type": "Domain"}, "IPR007522": {"description": "CRISPR-associated protein TM1795", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_TM1795", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007523": {"description": "NDUFAF3/Mth938 domain-containing protein", "go_ids": [], "go_terms": [], "name": "NDUFAF3/AAMDC", "pathway_ids": ["R-DME-6799198", "R-BTA-6799198", "R-HSA-6799198", "R-MMU-6799198", "R-RNO-6799198", "R-DRE-6799198", "R-XTR-6799198"], "pathways": ["R-DME-6799198:r:Complex I biogenesis", "R-BTA-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-6799198:r:Complex I biogenesis", "R-XTR-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR007524": {"description": "Pectate lyase, N-terminal", "go_ids": ["GO:0030570"], "go_terms": ["GO:0030570:pectate lyase activity:F"], "name": "Pec_lyase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007525": {"description": "Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "FrhB_FdhB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007526": {"description": "SWIRM domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "SWIRM", "pathway_ids": ["R-CEL-983231", "R-HSA-5689901", "R-MMU-9933946", "R-HSA-9772755", "R-MMU-9933937", "R-MMU-5689901", "R-MMU-3214815", "R-MMU-983231", "R-RNO-9018519", "R-HSA-3214858", "R-HSA-5625886", "R-HSA-9934037", "R-RNO-3214815", "R-DME-3214815", "R-RNO-3214842", "R-BTA-9772755", "R-RNO-983231", "R-RNO-5625886", "R-RNO-9772755", "R-SPO-9933946", "R-HSA-8943724", "R-MMU-3214842", "R-HSA-9845323", "R-DME-9764725", "R-DME-983231", "R-MMU-9772755", "R-MMU-5689603", "R-CEL-3214842", "R-HSA-9029569", "R-HSA-9018519", "R-DRE-5689901", "R-MMU-9934037", "R-DME-9018519", "R-DME-5625886", "R-HSA-3214842", "R-HSA-983231", "R-HSA-9933939", "R-HSA-3214815", "R-HSA-9933947", "R-HSA-9679191", "R-HSA-9764725", "R-MMU-9764725", "R-MMU-3214858", "R-MMU-8939243", "R-HSA-9824585", "R-MMU-9018519", "R-MMU-9933939", "R-HSA-8939243", "R-RNO-9764725", "R-MMU-9933947", "R-CEL-9764725", "R-HSA-9933937", "R-SPO-9933937", "R-HSA-3214847", "R-HSA-5689603", "R-HSA-9933946", "R-SPO-9933939"], "pathways": ["R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-5689901:r:Metalloprotease DUBs", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9933937:r:Formation 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complexes", "R-SPO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5689603:r:UCH proteinases", "R-CEL-3214842:r:HDMs demethylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DRE-5689901:r:Metalloprotease DUBs", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-SPO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-SPO-9933939:r:Formation of the polybromo-BAF (pBAF) complex"], "type": "Domain"}, "IPR007527": {"description": "Zinc finger, SWIM-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_SWIM", "pathway_ids": ["R-DDI-381070", "R-MMU-975871", "R-HSA-975871", "R-HSA-166058", "R-HSA-975138", "R-MMU-166058", "R-RNO-166058", "R-MMU-975138", "R-HSA-9010553", "R-HSA-2871796", "R-HSA-933542", "R-RNO-975138", "R-RNO-975871", "R-RNO-2871796", "R-MMU-2871796"], "pathways": ["R-DDI-381070:r:IRE1alpha activates chaperones", "R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-MMU-2871796:r:FCERI mediated MAPK activation"], "type": "Domain"}, "IPR007528": {"description": "RINT-1/Tip20", "go_ids": ["GO:0070939", "GO:0006890"], "go_terms": ["GO:0070939:Dsl1/NZR complex:C", "GO:0006890:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum:P"], "name": "RINT1_Tip20", "pathway_ids": ["R-DME-6811434", "R-HSA-6811434", "R-SCE-6811434", "R-SPO-6811434", "R-MMU-6811434"], "pathways": ["R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR007529": {"description": "Zinc finger, HIT-type", "go_ids": [], "go_terms": [], "name": "Znf_HIT", "pathway_ids": ["R-HSA-5689603", "R-MMU-5696394", "R-MMU-5689603", "R-HSA-5696394"], "pathways": ["R-HSA-5689603:r:UCH proteinases", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Domain"}, "IPR007530": {"description": "Aminoglycoside 6-adenylyltransferase", "go_ids": [], "go_terms": [], "name": "Aminoglycoside_adenylylTfrase", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Family"}, "IPR007531": {"description": "Dysbindin", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "Dysbindin", "pathway_ids": ["R-BTA-432722", "R-HSA-432722", "R-RNO-432722", "R-MMU-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR007532": {"description": "Poxvirus early transcription factor, large subunit", "go_ids": ["GO:0045893"], "go_terms": ["GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "Poxvirus_early-TF_lsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007533": {"description": "Cytochrome c oxidase assembly protein CtaG/Cox11", "go_ids": ["GO:0005507"], "go_terms": ["GO:0005507:copper ion binding:F"], "name": "Cyt_c_oxidase_assmbl_CtaG", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848", "R-BTA-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR007534": {"description": "Acyl-protein synthetase, LuxE", "go_ids": ["GO:0008218", "GO:0047474"], "go_terms": ["GO:0008218:bioluminescence:P", "GO:0047474:long-chain fatty acid--protein ligase activity:F"], "name": "LuxE", "pathway_ids": ["PWY-7723"], "pathways": ["PWY-7723:t:bacterial bioluminescence"], "type": "Domain"}, "IPR007535": {"description": "Catechol dioxygenase, N-terminal", "go_ids": ["GO:0005506", "GO:0009712", "GO:0018576"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0009712:catechol-containing compound metabolic process:P", "GO:0018576:catechol 1,2-dioxygenase activity:F"], "name": "Catechol_dOase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007536": {"description": "Ribosomal RNA small subunit methyltransferase J", "go_ids": ["GO:0008990", "GO:0031167"], "go_terms": ["GO:0008990:rRNA (guanine-N2-)-methyltransferase activity:F", "GO:0031167:rRNA methylation:P"], "name": "16SrRNA_methylTrfase_J", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007537": {"description": "tRNAHis guanylyltransferase Thg1", "go_ids": ["GO:0006400", "GO:0008193", "GO:0000287"], "go_terms": ["GO:0006400:tRNA modification:P", "GO:0008193:tRNA guanylyltransferase activity:F", "GO:0000287:magnesium ion binding:F"], "name": "tRNAHis_GuaTrfase_Thg1", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR007538": {"description": "dATP/dGTP diphosphohydrolase MazZ", "go_ids": [], "go_terms": [], "name": "dATP/dGTP_dipphydrolase_MazZ", "pathway_ids": ["PWY-7821", "PWY-6545", "PWY-7184", "PWY-7187", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR007539": {"description": "Domain of unknown function DUF551", "go_ids": [], "go_terms": [], "name": "DUF551", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007540": {"description": "Fimbrial major subunit, CS1-type", "go_ids": ["GO:0009289"], "go_terms": ["GO:0009289:pilus:C"], "name": "Fimbrial_CS1-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007541": {"description": "Uncharacterised protein family, basic secretory protein", "go_ids": [], "go_terms": [], "name": "Uncharacterised_BSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007542": {"description": "Major capsid protein, C-terminal", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "MCP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007543": {"description": "LptD, C-terminal", "go_ids": ["GO:0019867", "GO:0061024"], "go_terms": ["GO:0019867:outer membrane:C", "GO:0061024:membrane organization:P"], "name": "LptD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007544": {"description": "Type 1 encapsulin shell protein", "go_ids": [], "go_terms": [], "name": "ENCAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007545": {"description": "LOR/SDH bifunctional enzyme, conserved domain", "go_ids": [], "go_terms": [], "name": "LOR/SDH_bifunc_enz_cons_dom", "pathway_ids": ["PWY-4981"], "pathways": ["PWY-4981:t:L-proline biosynthesis II (from arginine)"], "type": "Domain"}, "IPR007546": {"description": "Protein of unknown function DUF503", "go_ids": [], "go_terms": [], "name": "DUF503", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007548": {"description": "Protein of unknown function DUF505", "go_ids": [], "go_terms": [], "name": "DUF505", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007549": {"description": "Domain of unknown function DUF512", "go_ids": [], "go_terms": [], "name": "DUF512", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007551": {"description": "Nucleotide-binding protein YajQ/Smlt4090-like", "go_ids": [], "go_terms": [], "name": "YajQ/Smlt4090-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007553": {"description": "2-thiouracil desulfurase", "go_ids": [], "go_terms": [], "name": "2-thiour_desulf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007554": {"description": "CDP-glycerol glycerophosphotransferase", "go_ids": ["GO:0016020", "GO:0047355"], "go_terms": ["GO:0016020:membrane:C", "GO:0047355:CDP-glycerol glycerophosphotransferase activity:F"], "name": "Glycerophosphate_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007555": {"description": "Domain of unknown function DUF499", "go_ids": [], "go_terms": [], "name": "DUF499", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007556": {"description": "Protein of unknown function DUF483", "go_ids": [], "go_terms": [], "name": "DUF483", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007557": {"description": "PSP1, C-terminal", "go_ids": [], "go_terms": [], "name": "PSP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007560": {"description": "Restriction endonuclease type IV, Mrr", "go_ids": ["GO:0003677", "GO:0004519", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004519:endonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_IV_Mrr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007561": {"description": "Cell division protein SepF/SepF-related", "go_ids": ["GO:0090529"], "go_terms": ["GO:0090529:cell septum assembly:P"], "name": "Cell_div_SepF/SepF-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007562": {"description": "Transglutaminase-like domain", "go_ids": [], "go_terms": [], "name": "Transglutaminase-like_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007563": {"description": "Protein of unknown function DUF554", "go_ids": [], "go_terms": [], "name": "DUF554", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007564": {"description": "Uncharacterised protein family UPF0212", "go_ids": [], "go_terms": [], "name": "UPF0212", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007565": {"description": "(5-formylfuran-3-yl)methyl phosphate synthase", "go_ids": [], "go_terms": [], "name": "4HFCP_synth", "pathway_ids": ["PWY-5254"], "pathways": ["PWY-5254:t:methanofuran biosynthesis"], "type": "Family"}, "IPR007566": {"description": "Phosphoenolpyruvate carboxylase, archaeal-type", "go_ids": ["GO:0006099", "GO:0008964", "GO:0015977"], "go_terms": ["GO:0006099:tricarboxylic acid cycle:P", "GO:0008964:phosphoenolpyruvate carboxylase activity:F", "GO:0015977:carbon fixation:P"], "name": "PEP_COase_arc-type", "pathway_ids": ["PWY-6549", "PWY-1622", "PWY-7124", "PWY-7115", "PWY-6146", "PWY-6142", "PWY-5913", "PWY-7117", "PWY-241"], "pathways": ["PWY-6549:t:nitrogen remobilization from senescing leaves", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-6146:t:Methanobacterium thermoautotrophicum biosynthetic metabolism", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-241:t:C4 photosynthetic carbon assimilation cycle, NADP-ME type"], "type": "Family"}, "IPR007567": {"description": "Mid2 domain", "go_ids": [], "go_terms": [], "name": "Mid2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007568": {"description": "RTA-like protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "RTA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007569": {"description": "Domain of unknown function DUF559", "go_ids": [], "go_terms": [], "name": "DUF559", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007570": {"description": "Uncharacterised protein family Ycf23", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007572": {"description": "Uncharacterised protein family Ycf20", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007573": {"description": "QWRF family", "go_ids": [], "go_terms": [], "name": "QWRF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007574": {"description": "Phycobilisome degradation protein NblA", "go_ids": [], "go_terms": [], "name": "NblA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007575": {"description": "SchA/CurD-like domain", "go_ids": [], "go_terms": [], "name": "SchA_CurD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007576": {"description": "CITED", "go_ids": ["GO:0005634", "GO:0006355"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "CITED", "pathway_ids": ["R-MMU-1234158", "R-HSA-8866907", "R-GGA-8866907", "R-HSA-8866906", "R-HSA-1234158", "R-BTA-8866907", "R-RNO-8866907", "R-MMU-8866907", "R-BTA-1234158", "R-HSA-9614657", "R-HSA-9018519", "R-MMU-9018519", "R-BTA-9018519"], "pathways": ["R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-GGA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-8866906:r:TFAP2 (AP-2) family regulates transcription of other transcription factors", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-BTA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-BTA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-BTA-9018519:r:Estrogen-dependent gene expression"], "type": "Family"}, "IPR007577": {"description": "Glycosyltransferase, DXD sugar-binding motif", "go_ids": [], "go_terms": [], "name": "GlycoTrfase_DXD", "pathway_ids": ["R-HSA-9840309", "R-DME-9840309", "R-DME-913709", "R-HSA-913709", "R-MMU-913709", "R-RNO-9840309", "R-MMU-9840309"], "pathways": ["R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-DME-9840309:r:Glycosphingolipid biosynthesis", "R-DME-913709:r:O-linked glycosylation of mucins", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis"], "type": "Conserved_site"}, "IPR007578": {"description": "Herpesvirus U10", "go_ids": [], "go_terms": [], "name": "Herpes_U10", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR007579": {"description": "Poxvirus T4 protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Poxvirus_T4p_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007580": {"description": "Poxvirus T4 protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Poxvirus_T4p_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007581": {"description": "Endonuclease V", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "Endonuclease-V", "pathway_ids": ["R-CEL-446193"], "pathways": ["R-CEL-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Family"}, "IPR007582": {"description": "TFIID subunit TAF5, NTD2 domain", "go_ids": [], "go_terms": [], "name": "TFIID_NTD2", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-SPO-9907900", "R-SCE-75953", "R-DME-76042", "R-SPO-6807505", "R-MMU-6804756", "R-CEL-9907900", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-SCE-6807505", "R-DME-9907900", "R-HSA-73776", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-DME-75953", "R-MMU-73779", "R-CEL-73776", "R-HSA-167172", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-CEL-6807505", "R-DME-674695", "R-MMU-674695", "R-MMU-6807505", "R-DME-6804756", "R-SCE-76042", "R-CEL-674695", "R-SCE-9907900", "R-DME-6807505", "R-HSA-167161", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-3214847", "R-HSA-674695", "R-HSA-76042", "R-SPO-73776", "R-CEL-76042", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-9907900:r:Proteasome assembly", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-9907900:r:Proteasome assembly", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-9907900:r:Proteasome assembly", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-9907900:r:Proteasome assembly", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR007583": {"description": "GRASP55/65", "go_ids": [], "go_terms": [], "name": "GRASP55_65", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-RNO-162658", "R-RNO-6807878", "R-MMU-162658", "R-SPO-162658", "R-HSA-6807878", "R-SCE-162658", "R-MMU-6807878", "R-RNO-204005", "R-HSA-162658"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-SPO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SCE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization"], "type": "Family"}, "IPR007584": {"description": "Herpesvirus UL35", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Herpes_UL35", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007585": {"description": "Poxvirus E2", "go_ids": [], "go_terms": [], "name": "Poxvirus_E2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007586": {"description": "Poxvirus VP8/L4R, nucleic acid binding", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "VP8_pox_nuc-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007587": {"description": "SIT4 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system:P"], "name": "Restrct_endonuc_II_XhoI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007637": {"description": "Restriction endonuclease, type II, DpnII-like", "go_ids": ["GO:0003677", "GO:0009036", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_II_DpnII-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007638": {"description": "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2", "go_ids": ["GO:0000166", "GO:0004819", "GO:0005524", "GO:0005737", "GO:0006425"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004819:glutamine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006425:glutaminyl-tRNA aminoacylation:P"], "name": "Gln-tRNA-synth_Ib_RNA-bd_2", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-RNO-9856649", "R-DME-9856649", "R-HSA-9856649", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR007639": {"description": "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal", 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"R-DME-9018519:r:Estrogen-dependent gene expression", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", 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"go_terms": [], "name": "Lipin_N", "pathway_ids": ["PWY-7782", "PWY-8053", "PWY-8052", "PWY-8051", "PWY-8055", "PWY-6453", "R-HSA-1483191", "R-SPO-75109", "R-HSA-4419969", "R-SCE-75109", "R-HSA-1483213", "R-SCE-1483213", "R-MMU-75109", "R-HSA-75109", "R-MMU-1483191", "R-SPO-1483213", "R-SPO-4419969", "R-SCE-1483191", "R-MMU-4419969", "R-SCE-4419969", "R-MMU-1483213", "R-HSA-9841922", "R-SPO-1483191"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-8053:t:anandamide biosynthesis II", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "R-HSA-1483191:r:Synthesis of PC", "R-SPO-75109:r:Triglyceride biosynthesis", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-75109:r:Triglyceride biosynthesis", "R-HSA-1483213:r:Synthesis of PE", "R-SCE-1483213:r:Synthesis of PE", "R-MMU-75109:r:Triglyceride biosynthesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-MMU-1483191:r:Synthesis of PC", "R-SPO-1483213:r:Synthesis of PE", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-1483191:r:Synthesis of PC", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-1483213:r:Synthesis of PE", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SPO-1483191:r:Synthesis of PC"], "type": "Domain"}, "IPR007652": {"description": "Alpha 1,4-glycosyltransferase domain", "go_ids": [], "go_terms": [], "name": "A1-4-GlycosylTfrase_dom", "pathway_ids": ["R-HSA-9840309", "R-DME-9840309", "R-DME-913709", "R-HSA-913709", "R-MMU-913709", "R-RNO-9840309", "R-MMU-9840309"], "pathways": ["R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-DME-9840309:r:Glycosphingolipid biosynthesis", "R-DME-913709:r:O-linked glycosylation of mucins", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis"], "type": "Domain"}, "IPR007653": {"description": "Signal peptidase complex subunit 3", "go_ids": ["GO:0005787", "GO:0016020", "GO:0051604"], "go_terms": ["GO:0005787:signal peptidase complex:C", "GO:0016020:membrane:C", "GO:0051604:protein maturation:P"], "name": "SPC3", "pathway_ids": ["R-MMU-422085", "R-HSA-1799339", "R-BTA-422085", "R-HSA-9828806", "R-HSA-9918432", "R-GGA-422085", "R-BTA-9768727", "R-HSA-381771", "R-HSA-9768727", "R-MMU-9768727", "R-GGA-9768727", "R-HSA-422085", "R-HSA-400511"], "pathways": ["R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9918432:r:Maturation of DENV proteins", "R-GGA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-GGA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Family"}, "IPR007654": {"description": "NAD-dependent histone deacetylase Sir2, N-terminal", "go_ids": [], "go_terms": [], "name": "NAD-dep_histone_deAcase_SIR2_N", "pathway_ids": ["R-SCE-3371453", "R-SPO-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR007655": {"description": "Surface lipoprotein assembly modifier, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Slam_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007656": {"description": "GTD-binding domain", "go_ids": [], "go_terms": [], "name": "GTD-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007657": {"description": "Glycosyltransferase 61", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "Glycosyltransferase_61", "pathway_ids": ["R-MMU-8932505", "R-GGA-8932505", "R-HSA-8932505", "R-XTR-8932505", "R-DRE-8932505", "R-RNO-8932505", "R-BTA-8932505"], "pathways": ["R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-GGA-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-XTR-8932505:r:DAG1 core M3 glycosylations", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-RNO-8932505:r:DAG1 core M3 glycosylations", "R-BTA-8932505:r:DAG1 core M3 glycosylations"], "type": "Family"}, "IPR007658": {"description": "Protein of unknown function DUF594", "go_ids": [], "go_terms": [], "name": "DUF594", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007659": {"description": "Keratin, high-sulphur matrix protein", "go_ids": ["GO:0005198", "GO:0045095"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0045095:keratin filament:C"], "name": "Keratin_matx", "pathway_ids": ["R-BTA-6805567", "R-MMU-6805567", "R-HSA-6805567"], "pathways": ["R-BTA-6805567:r:Keratinization", "R-MMU-6805567:r:Keratinization", "R-HSA-6805567:r:Keratinization"], "type": "Family"}, "IPR007660": {"description": "Poxvirus D3", "go_ids": [], "go_terms": [], "name": "Poxvirus_D3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007662": {"description": "Reovirus sigma C capsid protein, C-terminal", "go_ids": [], "go_terms": [], "name": "SigmaC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007663": {"description": "Baculoviridae p74", "go_ids": ["GO:0019058"], "go_terms": ["GO:0019058:viral life cycle:P"], "name": "Baculo_p74", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007664": {"description": "Poxvirus A28", "go_ids": ["GO:0016032", "GO:0019031"], "go_terms": ["GO:0016032:viral process:P", "GO:0019031:viral envelope:C"], "name": "Poxvirus_A28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007666": {"description": "ADP-specific phosphofructokinase/glucokinase", "go_ids": ["GO:0005975", "GO:0016773"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016773:phosphotransferase activity, alcohol group as acceptor:F"], "name": "ADP_PFK/GK", "pathway_ids": ["PWY-6855", "R-MMU-70171", "R-HSA-70171", "R-CEL-70171", "R-BTA-70171"], "pathways": ["PWY-6855:t:chitin degradation I (archaea)", "R-MMU-70171:r:Glycolysis", "R-HSA-70171:r:Glycolysis", "R-CEL-70171:r:Glycolysis", "R-BTA-70171:r:Glycolysis"], "type": "Family"}, "IPR007667": {"description": "Hypoxia induced protein, domain", "go_ids": [], "go_terms": [], "name": "Hypoxia_induced_domain", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-HSA-1234158", "R-HSA-9707564", "R-MMU-611105", "R-MMU-5628897", "R-MMU-9864848", "R-HSA-5628897", "R-MMU-9707564"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR007668": {"description": "RFX1 transcription activation region", "go_ids": ["GO:0003677", "GO:0005634", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RFX1_trans_act", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007669": {"description": "Carbohydrate sulfotransferase Chst-1-like", "go_ids": ["GO:0050650", "GO:1902884", "GO:0047756"], "go_terms": ["GO:0050650:chondroitin sulfate proteoglycan biosynthetic process:P", "GO:1902884:positive regulation of response to oxidative stress:P", "GO:0047756:chondroitin 4-sulfotransferase activity:F"], "name": "Chst-1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007670": {"description": "Protein of unknown function DUF596", "go_ids": [], "go_terms": [], "name": "DUF596", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007671": {"description": "Selenoprotein P, N-terminal", "go_ids": [], "go_terms": [], "name": "Selenoprotein-P_N", "pathway_ids": ["R-HSA-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR007672": {"description": "Selenoprotein P, C-terminal", "go_ids": [], "go_terms": [], "name": "SelP_C", "pathway_ids": ["R-HSA-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR007673": {"description": "Condensin subunit 1", "go_ids": ["GO:0005634", "GO:0000278", "GO:0030261"], "go_terms": ["GO:0005634:nucleus:C", "GO:0000278:mitotic cell cycle:P", "GO:0030261:chromosome condensation:P"], "name": "Condensin_cplx_su1", "pathway_ids": ["R-MMU-2514853", "R-HSA-2514853", "R-SCE-2514853", "R-SPO-2514853"], "pathways": ["R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes"], "type": "Family"}, "IPR007674": {"description": "Poxvirus F5/Telomere-binding protein I6 domain", "go_ids": ["GO:0016032"], "go_terms": ["GO:0016032:viral process:P"], "name": "Poxvirus_F5/I6_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007675": {"description": "Poxvirus F15", "go_ids": [], "go_terms": [], "name": "Poxvirus_F15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007676": {"description": "Ribophorin I", "go_ids": ["GO:0009101", "GO:0016020"], "go_terms": ["GO:0009101:glycoprotein biosynthetic process:P", "GO:0016020:membrane:C"], "name": "Ribophorin_I", "pathway_ids": ["R-HSA-1799339", "R-RNO-9931295", "R-CFA-9768727", "R-MMU-9931295", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9918432", "R-HSA-9931295", "R-CFA-9931295", "R-HSA-9768727", "R-MMU-9768727", "R-RNO-9768727"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "type": "Family"}, "IPR007677": {"description": "Gasdermin", "go_ids": [], "go_terms": [], "name": "Gasdermin", "pathway_ids": ["R-HSA-6798695", "R-HSA-111457", "R-HSA-448706", "R-MMU-9960525", "R-MMU-448706", "R-MMU-5686938", "R-MMU-9960519", "R-HSA-9960525", "R-MMU-111457", "R-HSA-9660826", "R-HSA-5620971", "R-MMU-6798695", "R-MMU-5620971", "R-HSA-5686938", "R-HSA-9960519"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-5620971:r:Pyroptosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5620971:r:Pyroptosis", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9960519:r:CASP4-mediated substrate cleavage"], "type": "Family"}, "IPR007678": {"description": "Poxvirus G5", "go_ids": [], "go_terms": [], "name": "Poxvirus_G5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007679": {"description": "Beta-trefoil domain of unknown function DUF569", "go_ids": [], "go_terms": [], "name": "DUF569", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007680": {"description": "Arabinofuranosyltransferase, central domain", "go_ids": ["GO:0071766", "GO:0052636"], "go_terms": ["GO:0071766:Actinobacterium-type cell wall biogenesis:P", "GO:0052636:arabinosyltransferase activity:F"], "name": "Arabino_trans_central", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis"], "type": "Domain"}, "IPR007681": {"description": "Ran-interacting Mog1 protein", "go_ids": [], "go_terms": [], "name": "Mog1", "pathway_ids": ["R-HSA-5576892"], "pathways": ["R-HSA-5576892:r:Phase 0 - rapid depolarisation"], "type": "Family"}, "IPR007682": {"description": "Lantibiotic, type A, Lactobacillales-type", "go_ids": ["GO:0005576", "GO:0042742"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042742:defense response to bacterium:P"], "name": "Lantibiotic_typ-A_Lactobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007684": {"description": "Zinc finger, Ogr/Delta-type", "go_ids": [], "go_terms": [], "name": "Znf_Ogr/Delta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007685": {"description": "RelA/SpoT", "go_ids": ["GO:0015969"], "go_terms": ["GO:0015969:guanosine tetraphosphate metabolic process:P"], "name": "RelA_SpoT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007686": {"description": "YutG/PgpA domain", "go_ids": ["GO:0006629", "GO:0008962"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0008962:phosphatidylglycerophosphatase activity:F"], "name": "YutG/PgpA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007687": {"description": "Methyl-coenzyme M reductase, protein C", "go_ids": [], "go_terms": [], "name": "Me_CoM_Rdtase_prot-C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007688": {"description": "Plasmid conjugal transfer TrbL/VirB6", "go_ids": ["GO:0030255"], "go_terms": ["GO:0030255:protein secretion by the type IV secretion system:P"], "name": "Conjugal_tfr_TrbL/VirB6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007689": {"description": "A-alpha-Y mating type-dependent binding domain", "go_ids": ["GO:0019953", "GO:0006355"], "go_terms": ["GO:0019953:sexual reproduction:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "AalphaY_mating_typ-dep-bd-dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007690": {"description": "Type II secretion system protein GspM", "go_ids": ["GO:0015628", "GO:0015627"], "go_terms": ["GO:0015628:protein secretion by the type II secretion system:P", "GO:0015627:type II protein secretion system complex:C"], "name": "T2SS_GspM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007691": {"description": "UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD", "go_ids": ["GO:0009245", "GO:0016747"], "go_terms": ["GO:0009245:lipid A biosynthetic process:P", "GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "LpxD", "pathway_ids": ["PWY-8245", "PWY-8073", "PWY-8283"], "pathways": ["PWY-8245:t:lipid IVA biosynthesis (P. gingivalis)", "PWY-8073:t:lipid IVA biosynthesis (P. putida)", "PWY-8283:t:lipid IVA biosynthesis (generic)"], "type": "Family"}, "IPR007692": {"description": "DNA helicase, DnaB type", "go_ids": ["GO:0003677", "GO:0003678", "GO:0005524", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003678:DNA helicase activity:F", "GO:0005524:ATP binding:F", "GO:0006260:DNA replication:P"], "name": "DNA_helicase_DnaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007693": {"description": "DNA helicase, DnaB-like, N-terminal", "go_ids": ["GO:0003678", "GO:0005524", "GO:0006260"], "go_terms": ["GO:0003678:DNA helicase activity:F", "GO:0005524:ATP binding:F", "GO:0006260:DNA replication:P"], "name": "DNA_helicase_DnaB-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007694": {"description": "DNA helicase, DnaB-like, C-terminal", "go_ids": ["GO:0003678", "GO:0005524", "GO:0006260"], "go_terms": ["GO:0003678:DNA helicase activity:F", "GO:0005524:ATP binding:F", "GO:0006260:DNA replication:P"], "name": "DNA_helicase_DnaB-like_C", "pathway_ids": ["R-DME-9913635", "R-HSA-9837999", "R-MMU-9837999", "R-HSA-2151201", "R-MMU-9913635", "R-DME-9837999", "R-HSA-9913635"], "pathways": ["R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR007695": {"description": "DNA mismatch repair protein MutS-like, N-terminal", "go_ids": ["GO:0005524", "GO:0006298", "GO:0030983"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006298:mismatch repair:P", "GO:0030983:mismatched DNA binding:F"], "name": "DNA_mismatch_repair_MutS-lik_N", "pathway_ids": ["R-BTA-5358606", "R-RNO-5358565", "R-SPO-5358565", "R-HSA-5632927", "R-HSA-5358606", "R-DDI-5358565", "R-SCE-5358606", "R-HSA-6796648", "R-DME-5358565", "R-HSA-5632928", "R-HSA-5632968", "R-BTA-5358565", "R-SCE-5358565", "R-SPO-5358606", "R-HSA-5358565", "R-MMU-5358606", "R-MMU-5358565"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "type": "Domain"}, "IPR007696": {"description": "DNA mismatch repair protein MutS, core", "go_ids": ["GO:0005524", "GO:0006298", "GO:0030983"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006298:mismatch repair:P", "GO:0030983:mismatched DNA binding:F"], "name": "DNA_mismatch_repair_MutS_core", "pathway_ids": ["R-BTA-5358606", "R-RNO-5358565", "R-SPO-5358565", "R-HSA-5632927", "R-HSA-5358606", "R-DDI-5358565", "R-SCE-5358606", "R-HSA-6796648", "R-DME-5358565", "R-HSA-5632928", "R-HSA-5632968", "R-BTA-5358565", "R-SCE-5358565", "R-HSA-912446", "R-SPO-5358606", "R-HSA-5358565", "R-MMU-5358606", "R-MMU-5358565"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "type": "Domain"}, "IPR007698": {"description": "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain", "go_ids": [], "go_terms": [], "name": "AlaDH/PNT_NAD(H)-bd", "pathway_ids": ["R-BTA-71403", "R-MMU-71064", "R-BTA-71064", "R-MMU-71403", "R-RNO-71064", "R-HSA-71403", "R-HSA-71064"], "pathways": ["R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-71064:r:Lysine catabolism", "R-BTA-71064:r:Lysine catabolism", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71064:r:Lysine catabolism", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71064:r:Lysine catabolism"], "type": "Domain"}, "IPR007699": {"description": "SGS domain", "go_ids": [], "go_terms": [], "name": "SGS_dom", "pathway_ids": ["R-HSA-9660826", "R-SCE-844456", "R-SPO-844456", "R-DDI-844456", "R-RNO-844456", "R-MMU-844456", "R-BTA-844456", "R-HSA-844456"], "pathways": ["R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-SCE-844456:r:The NLRP3 inflammasome", "R-SPO-844456:r:The NLRP3 inflammasome", "R-DDI-844456:r:The NLRP3 inflammasome", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-BTA-844456:r:The NLRP3 inflammasome", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Domain"}, "IPR007700": {"description": "Domain of unknown function DUF668", "go_ids": ["GO:0045927"], "go_terms": ["GO:0045927:positive regulation of growth:P"], "name": "DUF668", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007701": {"description": "Interferon-related developmental regulator, N-terminal", "go_ids": [], "go_terms": [], "name": "Interferon-rel_develop_reg_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007702": {"description": "Janus", "go_ids": [], "go_terms": [], "name": "Janus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007703": {"description": "Per os infectivity factor 3", "go_ids": [], "go_terms": [], "name": "PIF3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007704": {"description": "GPI mannosyltransferase 1", "go_ids": ["GO:0004376", "GO:0051751", "GO:0006506", "GO:0016020"], "go_terms": ["GO:0004376:GPI mannosyltransferase activity:F", "GO:0051751:alpha-1,4-mannosyltransferase activity:F", "GO:0006506:GPI anchor biosynthetic process:P", "GO:0016020:membrane:C"], "name": "PIG-M", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-MMU-162710", "R-XTR-162710", "R-HSA-162710", "R-RNO-162710", "R-DRE-162710", "R-DDI-162710"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-XTR-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-DRE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-DDI-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR007705": {"description": "Vesicle transport v-SNARE, N-terminal", "go_ids": ["GO:0006886", "GO:0016020"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0016020:membrane:C"], "name": "Vesicle_trsprt_v-SNARE_N", "pathway_ids": ["R-HSA-114608", "R-SCE-6811440", "R-RNO-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-HSA-6811440", "R-RNO-6811438", "R-DDI-6811440", "R-SCE-114608", "R-RNO-114608", "R-SPO-6811440", "R-DDI-114608", "R-DDI-6811438", "R-SPO-114608", "R-MMU-6811440", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811438:r:Intra-Golgi traffic", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-114608:r:Platelet degranulation", "R-DDI-6811438:r:Intra-Golgi traffic", "R-SPO-114608:r:Platelet degranulation", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR007706": {"description": "Epstein-Barr virus nuclear antigen 3/4/6", "go_ids": ["GO:0016032"], "go_terms": ["GO:0016032:viral process:P"], "name": "EBNA-3/4/6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007707": {"description": "Transforming acidic coiled-coil-containing protein, C-terminal", "go_ids": [], "go_terms": [], "name": "TACC_C", "pathway_ids": ["R-HSA-9604323", "R-HSA-9013507"], "pathways": ["R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus"], "type": "Domain"}, "IPR007708": {"description": "Lariat debranching enzyme, C-terminal", "go_ids": ["GO:0006397", "GO:0016788"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "DBR1_C", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I"], "type": "Domain"}, "IPR007709": {"description": "N-formylglutamate amidohydrolase", "go_ids": [], "go_terms": [], "name": "N-FG_amidohydro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007710": {"description": "Nucleoside 2-deoxyribosyltransferase", "go_ids": [], "go_terms": [], "name": "Nucleoside_deoxyribTrfase", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-74259", "R-MMU-74259", "R-RNO-74259", "R-DRE-74259"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-74259:r:Purine catabolism", "R-MMU-74259:r:Purine catabolism", "R-RNO-74259:r:Purine catabolism", "R-DRE-74259:r:Purine catabolism"], "type": "Family"}, "IPR007711": {"description": "Toxin HigB-1", "go_ids": [], "go_terms": [], "name": "HigB-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007712": {"description": "Toxin-antitoxin system, RelE/ParE toxin family", "go_ids": [], "go_terms": [], "name": "RelE/ParE_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007713": {"description": "TMP repeat", "go_ids": [], "go_terms": [], "name": "TMP_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR007714": {"description": "CFA20 domain", "go_ids": [], "go_terms": [], "name": "CFA20_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007715": {"description": "Ubiquinone biosynthesis protein Coq4", "go_ids": ["GO:0006744"], "go_terms": ["GO:0006744:ubiquinone biosynthetic process:P"], "name": "Coq4", "pathway_ids": ["R-DRE-2142789", "R-SPO-2142789", "R-SCE-2142789", "R-MMU-2142789", "R-DDI-2142789", "R-HSA-2142789", "R-BTA-2142789", "R-RNO-2142789", "R-CEL-2142789", "R-DME-2142789", "R-XTR-2142789"], "pathways": ["R-DRE-2142789:r:Ubiquinol biosynthesis", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-BTA-2142789:r:Ubiquinol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-CEL-2142789:r:Ubiquinol biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis", "R-XTR-2142789:r:Ubiquinol biosynthesis"], "type": "Family"}, "IPR007716": {"description": "NPL4, zinc-binding putative", "go_ids": [], "go_terms": [], "name": "NPL4_Zn-bd_put", "pathway_ids": ["R-CEL-9755511", "R-HSA-8951664", "R-DME-110320", "R-RNO-9755511", "R-MMU-110320", "R-DME-8951664", "R-SCE-9755511", "R-HSA-9918487", "R-HSA-9755511", "R-MMU-9755511", "R-RNO-110320", "R-SPO-9755511", "R-DME-9755511", "R-MMU-8951664", "R-SCE-8951664", "R-CEL-110320", "R-HSA-9954709", "R-SPO-110320", "R-RNO-8951664", "R-SPO-8951664", "R-HSA-110320", "R-CEL-8951664"], "pathways": ["R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-DME-110320:r:Translesion Synthesis by POLH", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-DME-8951664:r:Neddylation", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8951664:r:Neddylation", "R-SCE-8951664:r:Neddylation", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-RNO-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR007717": {"description": "Nuclear pore localisation protein NPL4, C-terminal", "go_ids": [], "go_terms": [], "name": "NPL4_C", "pathway_ids": ["R-DDI-9755511", "R-CEL-9755511", "R-HSA-8951664", "R-DME-110320", "R-RNO-9755511", "R-MMU-110320", "R-DME-8951664", "R-SCE-9755511", "R-HSA-9918487", "R-HSA-9755511", "R-MMU-9755511", "R-RNO-110320", "R-SPO-9755511", "R-DDI-8951664", "R-DME-9755511", "R-MMU-8951664", "R-SCE-8951664", "R-CEL-110320", "R-HSA-9954709", "R-SPO-110320", "R-RNO-8951664", "R-SPO-8951664", "R-HSA-110320", "R-CEL-8951664"], "pathways": ["R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-DME-110320:r:Translesion Synthesis by POLH", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-DME-8951664:r:Neddylation", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-8951664:r:Neddylation", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8951664:r:Neddylation", "R-SCE-8951664:r:Neddylation", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-RNO-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR007718": {"description": "Srp40, C-terminal", "go_ids": [], "go_terms": [], "name": "Srp40_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007719": {"description": "Phytochelatin synthase, N-terminal catalytic domain", "go_ids": ["GO:0010038", "GO:0016756", "GO:0046872", "GO:0046938"], "go_terms": ["GO:0010038:response to metal ion:P", "GO:0016756:glutathione gamma-glutamylcysteinyltransferase activity:F", "GO:0046872:metal ion binding:F", "GO:0046938:phytochelatin biosynthetic process:P"], "name": "PCS_N", "pathway_ids": ["PWY-6745"], "pathways": ["PWY-6745:t:phytochelatins biosynthesis"], "type": "Domain"}, "IPR007720": {"description": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q/GPI1", "go_ids": ["GO:0006506", "GO:0016020"], "go_terms": ["GO:0006506:GPI anchor biosynthetic process:P", "GO:0016020:membrane:C"], "name": "PigQ/GPI1", "pathway_ids": ["R-HSA-162710", "R-SPO-162710", "R-MMU-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR007721": {"description": "D-ribose pyranase RbsD/L-fucose mutarotase FucU", "go_ids": ["GO:0005996", "GO:0016853", "GO:0048029"], "go_terms": ["GO:0005996:monosaccharide metabolic process:P", "GO:0016853:isomerase activity:F", "GO:0048029:monosaccharide binding:F"], "name": "RbsD_FucU", "pathway_ids": ["R-DRE-6787639", "R-HSA-6787639", "R-MMU-6787639"], "pathways": ["R-DRE-6787639:r:GDP-fucose biosynthesis", "R-HSA-6787639:r:GDP-fucose biosynthesis", "R-MMU-6787639:r:GDP-fucose biosynthesis"], "type": "Family"}, "IPR007722": {"description": "mRNA decapping protein 2, Box A domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "DCP2_BoxA", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-HSA-380994", "R-MMU-450513", "R-MMU-430039", "R-MMU-450604", "R-CEL-450385", "R-HSA-450513", "R-SCE-450513", "R-HSA-450604", "R-SCE-430039", "R-CEL-430039", "R-CEL-450513", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR007724": {"description": "Poly(ADP-ribose) glycohydrolase", "go_ids": ["GO:0004649", "GO:0005975", "GO:0006282"], "go_terms": ["GO:0004649:poly(ADP-ribose) glycohydrolase activity:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0006282:regulation of DNA repair:P"], "name": "Poly_GlycHdrlase", "pathway_ids": ["R-HSA-110362", "R-MMU-110362", "R-RNO-110362"], "pathways": ["R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR007725": {"description": "Timeless, PAB domain", "go_ids": [], "go_terms": [], "name": "TIMELESS_PAB", "pathway_ids": ["R-DME-432620", "R-DME-538898", "R-HSA-5693607", "R-DME-432553", "R-DME-432395", "R-RNO-5693607", "R-DME-432490", "R-DME-432501", "R-MMU-5693607"], "pathways": ["R-DME-432620:r:Dephosphorylation of PER", "R-DME-538898:r:Dephosphorylation of TIM", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-432395:r:Degradation of TIM", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DME-432490:r:Nuclear import of PER and TIM", "R-DME-432501:r:Transcription repression by PER and activation by PDP1", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Domain"}, "IPR007726": {"description": "SS18, N-terminal", "go_ids": [], "go_terms": [], "name": "SS18_N", "pathway_ids": ["R-MMU-9933946", "R-MMU-9934037", "R-MMU-9933947", "R-HSA-9933937", "R-HSA-9845323", "R-HSA-9934037", "R-MMU-9933937", "R-HSA-9933947", "R-BTA-9933947", "R-HSA-9933946", "R-HSA-9824585", "R-RNO-9933937", "R-RNO-9933947", "R-BTA-9933937"], "pathways": ["R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-BTA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-RNO-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex"], "type": "Domain"}, "IPR007727": {"description": "Spo12", "go_ids": [], "go_terms": [], "name": "Spo12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007728": {"description": "Pre-SET domain", "go_ids": ["GO:0005634", "GO:0008270", "GO:0042054"], "go_terms": ["GO:0005634:nucleus:C", "GO:0008270:zinc ion binding:F", "GO:0042054:histone methyltransferase activity:F"], "name": "Pre-SET_dom", "pathway_ids": ["R-HSA-8853884", "R-MMU-6804760", "R-MMU-8953750", "R-MMU-73762", "R-MMU-3214841", "R-MMU-9843940", "R-DRE-9843940", "R-DRE-9843970", "R-MMU-2559582", "R-CEL-3214841", "R-DME-427359", "R-HSA-73762", "R-HSA-8953750", "R-HSA-2559582", "R-HSA-6804760", "R-HSA-3214841", "R-HSA-427359", "R-DRE-3214841", "R-HSA-9843970", "R-DME-3214841", "R-DME-9843940", "R-HSA-9843940", "R-HSA-427389"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-DME-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DME-3214841:r:PKMTs methylate histone lysines", "R-DME-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"], "type": "Domain"}, "IPR007729": {"description": "2-keto-3-deoxy-galactonokinase", "go_ids": ["GO:0034194", "GO:0008671"], "go_terms": ["GO:0034194:D-galactonate catabolic process:P", "GO:0008671:2-dehydro-3-deoxygalactonokinase activity:F"], "name": "DGOK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007730": {"description": "Sporulation-like domain", "go_ids": ["GO:0042834"], "go_terms": ["GO:0042834:peptidoglycan binding:F"], "name": "SPOR-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007731": {"description": "Protein of unknown function DUF669", "go_ids": [], "go_terms": [], "name": "DUF669", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007732": {"description": "Cytochrome b558 alpha-subunit", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "Cyt_b558_asu", "pathway_ids": ["R-RNO-1236973", "R-HSA-6798695", "R-MMU-1222556", "R-HSA-3299685", "R-RNO-6798695", "R-BTA-1222556", "R-RNO-4420097", "R-RNO-5668599", "R-BTA-6798695", "R-HSA-1236973", "R-RNO-9013149", "R-MMU-4420097", "R-RNO-1222556", "R-MMU-9013404", "R-HSA-9673324", "R-MMU-3299685", "R-MMU-1236973", "R-RNO-3299685", "R-BTA-9013423", "R-HSA-9013404", "R-HSA-9013423", "R-HSA-4420097", "R-HSA-9013149", "R-MMU-9013423", "R-BTA-5668599", "R-BTA-4420097", "R-BTA-3299685", "R-HSA-1222556", "R-RNO-9013423", "R-BTA-9013404", "R-MMU-5668599", "R-MMU-6798695", "R-RNO-9013404", "R-MMU-9013149", "R-HSA-5668599", "R-BTA-1236973"], "pathways": ["R-RNO-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)"], "type": "Family"}, "IPR007733": {"description": "Agouti", "go_ids": ["GO:0005576", "GO:0009755"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0009755:hormone-mediated signaling pathway:P"], "name": "Agouti", "pathway_ids": ["R-HSA-9615017"], "pathways": ["R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "type": "Family"}, "IPR007734": {"description": "Heparan sulphate 2-O-sulfotransferase", "go_ids": ["GO:0008146", "GO:0016020"], "go_terms": ["GO:0008146:sulfotransferase activity:F", "GO:0016020:membrane:C"], "name": "Heparan_SO4_2-O-STrfase", "pathway_ids": ["PWY-8045", "PWY-7831", "PWY-8381", "PWY-6558", "PWY-6546", "PWY-6568", "PWY-6567", "PWY-8358", "R-GGA-2022928", "R-MMU-2022870", "R-CEL-2022928", "R-DME-2022928", "R-DME-2022870", "R-HSA-2022923", "R-HSA-2022870", "R-MMU-2022928", "R-HSA-2022928", "R-DME-2022923", "R-MMU-2022923"], "pathways": ["PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7831:t:ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-6546:t:brassinosteroids inactivation", "PWY-6568:t:dermatan sulfate biosynthesis", "PWY-6567:t:chondroitin sulfate biosynthesis", "PWY-8358:t:curacin A biosynthesis", "R-GGA-2022928:r:HS-GAG biosynthesis", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-DME-2022928:r:HS-GAG biosynthesis", "R-DME-2022870:r:CS-GAG biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-DME-2022923:r:DS-GAG biosynthesis", "R-MMU-2022923:r:DS-GAG biosynthesis"], "type": "Family"}, "IPR007735": {"description": "Pecanex, C-terminal", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Pecanex_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007736": {"description": "Caleosin-related", "go_ids": [], "go_terms": [], "name": "Caleosin-related", "pathway_ids": ["PWY-321", "PWY-6917", "PWY-5410"], "pathways": ["PWY-321:t:cutin biosynthesis", "PWY-6917:t:vernolate biosynthesis III", "PWY-5410:t:traumatin and (Z)-3-hexen-1-yl acetate biosynthesis"], "type": "Family"}, "IPR007737": {"description": "Mga helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "Mga_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007739": {"description": "Rhamnan synthesis F-like domain", "go_ids": [], "go_terms": [], "name": "RgpF-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007740": {"description": "Large ribosomal subunit protein mL49", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_mL49", "pathway_ids": ["R-HSA-5419276", "R-CEL-9937383", "R-MMU-9937383", "R-HSA-5368286", "R-CEL-5389840", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9937383", "R-CEL-5419276", "R-HSA-5389840", "R-DME-5389840", "R-MMU-5389840", "R-DME-9937383"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR007741": {"description": "Ribosomal protein/NADH dehydrogenase domain", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL43/mS25/NADH_DH", "pathway_ids": ["R-MMU-9837999", "R-HSA-5419276", "R-MMU-9937383", "R-CEL-5389840", "R-MMU-6799198", "R-HSA-6799198", "R-HSA-9937383", "R-BTA-9937383", "R-MMU-5389840", "R-BTA-5389840", "R-HSA-611105", "R-CEL-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-BTA-9837999", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9837999", "R-CEL-5419276", "R-HSA-5389840", "R-RNO-9937383", "R-DME-5389840", "R-BTA-6799198", "R-DME-9937383", "R-RNO-5389840", "R-BTA-611105"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-611105:r:Respiratory electron transport", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-BTA-6799198:r:Complex I biogenesis", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR007742": {"description": "Periplasmic copper-binding protein NosD-like, beta helix domain", "go_ids": [], "go_terms": [], "name": "NosD_dom", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR007743": {"description": "Immunity-related GTPases-like", "go_ids": ["GO:0005525", "GO:0016020"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0016020:membrane:C"], "name": "Immunity-related_GTPase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007745": {"description": "Cytochrome c oxidase copper chaperone", "go_ids": ["GO:0005507", "GO:0005758", "GO:0016531"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0005758:mitochondrial intermembrane space:C", "GO:0016531:copper chaperone activity:F"], "name": "Cyt_c_oxidase_Cu-chaperone", "pathway_ids": ["R-CFA-9864848", "R-HSA-1268020", "R-MMU-9864848", "R-HSA-9864848"], "pathways": ["R-CFA-9864848:r:Complex IV assembly", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-9864848:r:Complex IV assembly", "R-HSA-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR007746": {"description": "Broad mercury transporter MerE", "go_ids": ["GO:0015694", "GO:0016020", "GO:0015097"], "go_terms": ["GO:0015694:mercury ion transport:P", "GO:0016020:membrane:C", "GO:0015097:mercury ion transmembrane transporter activity:F"], "name": "MerE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007747": {"description": "Menin", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "Menin", "pathway_ids": ["R-CFA-381426", "R-MMU-5626467", "R-HSA-3769402", "R-RNO-201722", "R-HSA-9772755", "R-HSA-5626467", "R-MMU-2173796", "R-RNO-5626467", "R-MMU-201722", "R-BTA-201722", "R-CFA-9772755", "R-MMU-8957275", "R-BTA-2173796", "R-HSA-2173796", "R-BTA-8957275", "R-HSA-201722", "R-BTA-9772755", "R-RNO-381426", "R-RNO-8957275", "R-RNO-9772755", "R-MMU-381426", "R-BTA-381426", "R-BTA-5626467", "R-CFA-8957275", "R-HSA-8957275", "R-MMU-9772755", "R-RNO-3769402", "R-CFA-2173796", "R-CFA-201722", "R-HSA-381426", "R-RNO-2173796"], "pathways": ["R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-BTA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CFA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-5626467:r:RHO GTPases activate IQGAPs", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CFA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "type": "Family"}, "IPR007748": {"description": "Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf109", "go_ids": [], "go_terms": [], "name": "AcMNPV_Orf109", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007749": {"description": "Protein of unknown function DUF677", "go_ids": [], "go_terms": [], "name": "DUF677", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007750": {"description": "Protein of unknown function DUF674", "go_ids": [], "go_terms": [], "name": "DUF674", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007751": {"description": "Domain of unknown function DUF676, lipase-like", "go_ids": [], "go_terms": [], "name": "DUF676_lipase-like", "pathway_ids": ["R-HSA-9696273", "R-MMU-9696273"], "pathways": ["R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR007752": {"description": "Virulence factor ActA", "go_ids": [], "go_terms": [], "name": "Virulence_actor_ActA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007753": {"description": "Orbivirus VP4 core", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Orbi_VP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007754": {"description": "N-acetylglucosaminyltransferase II", "go_ids": ["GO:0005795", "GO:0008455", "GO:0009312", "GO:0016020"], "go_terms": ["GO:0005795:Golgi stack:C", "GO:0008455:alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity:F", "GO:0009312:oligosaccharide biosynthetic process:P", "GO:0016020:membrane:C"], "name": "GlcNAc_II", "pathway_ids": ["PWY-7920", "PWY-7426", "R-RNO-975578", "R-MMU-975578", "R-HSA-975578", "R-HSA-9694548", "R-HSA-4793952"], "pathways": ["PWY-7920:t:complex N-linked glycan biosynthesis (plants)", "PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-4793952:r:Defective MGAT2 causes CDG-2a"], "type": "Family"}, "IPR007755": {"description": "Poxvirus A11", "go_ids": [], "go_terms": [], "name": "Poxvirus_A11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007756": {"description": "RICH domain", "go_ids": [], "go_terms": [], "name": "RICH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007757": {"description": "MT-A70-like", "go_ids": [], "go_terms": [], "name": "MT-A70-like", "pathway_ids": ["R-XTR-72203", "R-HSA-72203", "R-DME-72203", "R-MMU-72203", "R-DRE-72203"], "pathways": ["R-XTR-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Family"}, "IPR007758": {"description": "Nucleoporin, NSP1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Nucleoporin_NSP1_C", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-SPO-3371453", 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"GO:0005737"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F", "GO:0016226:iron-sulfur cluster assembly:P", "GO:0005737:cytoplasm:C"], "name": "Anamorsin", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Family"}, "IPR007786": {"description": "Late expression factor 9", "go_ids": ["GO:0019083"], "go_terms": ["GO:0019083:viral transcription:P"], "name": "LEF-9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007787": {"description": "Protein of unknown function DUF687", "go_ids": [], "go_terms": [], "name": "DUF687", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007788": {"description": "Glutaminyl-peptide cyclotransferase", "go_ids": ["GO:0016603", "GO:0017186"], "go_terms": ["GO:0016603:glutaminyl-peptide cyclotransferase activity:F", "GO:0017186:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase:P"], "name": "QCT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007789": {"description": "Protein of unknown function DUF688", "go_ids": [], "go_terms": [], "name": "DUF688", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007790": {"description": "Late expression factor 4", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "LEF-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007791": {"description": "Co-chaperone DjlA, N-terminal", "go_ids": [], "go_terms": [], "name": "DjlA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007792": {"description": "Type IV secretion system VirB3/TrbD-like", "go_ids": [], "go_terms": [], "name": "T4SS_VirB3/TrbD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007793": {"description": "DivIVA", "go_ids": [], "go_terms": [], "name": "DivIVA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007794": {"description": "Ribosome receptor lysine/proline rich", "go_ids": ["GO:0015031", "GO:0005789"], "go_terms": ["GO:0015031:protein transport:P", "GO:0005789:endoplasmic reticulum membrane:C"], "name": "Rib_rcpt_KP", "pathway_ids": ["R-HSA-9696270", "R-MMU-8980692", "R-MMU-9013408", "R-HSA-9918487", "R-MMU-9013148", "R-MMU-5625970", "R-MMU-8957275", "R-HSA-9696264", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-381426", "R-MMU-9013149", "R-HSA-9013148", "R-HSA-8957275", "R-MMU-9696264", "R-HSA-9013408", "R-MMU-9696270", "R-HSA-9725370", "R-HSA-5625970", "R-HSA-381426"], "pathways": ["R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-5625970:r:RHO GTPases activate KTN1", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5625970:r:RHO GTPases activate KTN1", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR007795": {"description": "Type VII secretion system EccB", "go_ids": [], "go_terms": [], "name": "T7SS_EccB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007796": {"description": "Envelope glycoprotein GP350, N-terminal, A domain, herpervirus", "go_ids": [], "go_terms": [], "name": "GP350_N_A_dom_herpes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007797": {"description": "AF4/FMR2 family", "go_ids": ["GO:0010468"], "go_terms": ["GO:0010468:regulation of gene expression:P"], "name": "AF4/FMR2", "pathway_ids": ["R-DME-112382", "R-HSA-112382", "R-DME-674695", "R-HSA-75955", "R-MMU-75955", "R-HSA-674695", "R-DME-75955", "R-MMU-674695", "R-MMU-112382"], "pathways": ["R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex"], "type": "Family"}, "IPR007798": {"description": "Ameloblastin precursor", "go_ids": ["GO:0030345", "GO:0042475"], "go_terms": ["GO:0030345:structural constituent of tooth enamel:F", "GO:0042475:odontogenesis of dentin-containing tooth:P"], "name": "Amelin", "pathway_ids": ["R-RNO-381426", "R-HSA-381426", "R-HSA-8957275", "R-SSC-381426", "R-RNO-8957275", "R-SSC-8957275", "R-MMU-8957275", "R-MMU-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR007799": {"description": "Baculovirus p47", "go_ids": ["GO:0046782"], "go_terms": ["GO:0046782:regulation of viral transcription:P"], "name": "Baculo_p47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007800": {"description": "Protein of unknown function DUF693", "go_ids": [], "go_terms": [], "name": "DUF693", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007801": {"description": "RiPP precursor modification enzyme MbnB/TglH/ChrH", "go_ids": [], "go_terms": [], "name": "MbnB/TglH/ChrH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007802": {"description": "Cytochrome b6-f complex subunit 6", "go_ids": ["GO:0009055", "GO:0009512"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0009512:cytochrome b6f complex:C"], "name": "Cyt_b6/f_cplx_su6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007803": {"description": "Aspartyl/asparaginy/proline hydroxylase", "go_ids": ["GO:0018193"], "go_terms": ["GO:0018193:peptidyl-amino acid modification:P"], "name": "Asp/Arg/Pro-Hydrxlase", "pathway_ids": ["R-HSA-5578775", "R-HSA-2672351", "R-MMU-5578775", "R-MMU-2672351", "R-BTA-5578775", "R-HSA-9629569", "R-BTA-2672351"], "pathways": ["R-HSA-5578775:r:Ion homeostasis", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-2672351:r:Stimuli-sensing channels", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-9629569:r:Protein hydroxylation", "R-BTA-2672351:r:Stimuli-sensing channels"], "type": "Domain"}, "IPR007804": {"description": "Gas vesicle protein G", "go_ids": [], "go_terms": [], "name": "GvpG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007805": {"description": "Gas vesicle protein K", "go_ids": ["GO:0031412"], "go_terms": ["GO:0031412:gas vesicle organization:P"], "name": "GvpK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007806": {"description": "Mobile element transfer", "go_ids": [], "go_terms": [], "name": "SpdB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007807": {"description": "TcmA/NAT10, helicase domain", "go_ids": [], "go_terms": [], "name": "TcmA/NAT10_helicase", "pathway_ids": ["R-HSA-6790901"], "pathways": ["R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR007808": {"description": "Transcription elongation factor 1", "go_ids": [], "go_terms": [], "name": "Elf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007809": {"description": "FlgN-like protein", "go_ids": ["GO:0044780", "GO:0005515"], "go_terms": ["GO:0044780:bacterial-type flagellum assembly:P", "GO:0005515:protein binding:F"], "name": "FlgN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007810": {"description": "Pep3/Vps18, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Pep3/Vps18_beta-prop", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR007811": {"description": "DNA-directed RNA polymerase III subunit RPC4", "go_ids": ["GO:0003677", "GO:0005666", "GO:0006383"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005666:RNA polymerase III complex:C", "GO:0006383:transcription by RNA polymerase III:P"], "name": "RPC4", "pathway_ids": ["R-HSA-76071", "R-SCE-76066", "R-DDI-76066", "R-DDI-76061", "R-HSA-76066", "R-SPO-76066", "R-HSA-73980", "R-HSA-76061", "R-SPO-76061", "R-HSA-1834949", "R-HSA-73780", "R-MMU-76071", "R-MMU-76066", "R-HSA-749476", "R-MMU-76061", "R-SCE-76061"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR007812": {"description": "Type II secretion system protein GspL", "go_ids": ["GO:0009276", "GO:0015628", "GO:0015627"], "go_terms": ["GO:0009276:Gram-negative-bacterium-type cell wall:C", "GO:0015628:protein secretion by the type II secretion system:P", "GO:0015627:type II protein secretion system complex:C"], "name": "T2SS_protein-GspL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007813": {"description": "Type IV pilus inner membrane component PilN", "go_ids": [], "go_terms": [], "name": "PilN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007814": {"description": "1,2-phenylacetyl-CoA epoxidase, subunit A/C", "go_ids": ["GO:0010124"], "go_terms": ["GO:0010124:phenylacetate catabolic process:P"], "name": "PaaA_PaaC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007815": {"description": "Erythromycin esterase", "go_ids": ["GO:0046677"], "go_terms": ["GO:0046677:response to antibiotic:P"], "name": "Emycin_Estase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007816": {"description": "ResB-like domain", "go_ids": [], "go_terms": [], "name": "ResB-like_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007817": {"description": "Isocyanide synthase/Spore wall maturation protein DIT1", "go_ids": [], "go_terms": [], "name": "Isocyanide_synthase_DIT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007818": {"description": "SHI protein family", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "SHI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007820": {"description": "AbrB family", "go_ids": ["GO:0016020", "GO:0010468"], "go_terms": ["GO:0016020:membrane:C", "GO:0010468:regulation of gene expression:P"], "name": "AbrB_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007822": {"description": "Lanthionine synthetase C-like", "go_ids": ["GO:0031179"], "go_terms": ["GO:0031179:peptide modification:P"], "name": "LANC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007823": {"description": "Ribosomal RNA processing protein 8", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "RRP8", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-RNO-427359", "R-DME-427359", "R-HSA-427359"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-RNO-427359:r:SIRT1 negatively regulates rRNA expression", "R-DME-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression"], "type": "Family"}, "IPR007824": {"description": "Paraflagellar rod", "go_ids": ["GO:0005516", "GO:0031514"], "go_terms": ["GO:0005516:calmodulin binding:F", "GO:0031514:motile cilium:C"], "name": "Flagellar_rod", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007825": {"description": "Major outer membrane precursor, Legionella pneumophila-type", "go_ids": [], "go_terms": [], "name": "Major_OMP_Legionella", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007826": {"description": "Photosystem II PsbM", "go_ids": ["GO:0009523", "GO:0016020", "GO:0019684", "GO:0015979"], "go_terms": ["GO:0009523:photosystem II:C", "GO:0016020:membrane:C", "GO:0019684:photosynthesis, light reaction:P", "GO:0015979:photosynthesis:P"], "name": "PSII_PsbM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007827": {"description": "Protein of unknown function DUF694", "go_ids": [], "go_terms": [], "name": "DUF705", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007828": {"description": "Inositol oxygenase", "go_ids": ["GO:0005506", "GO:0005737", "GO:0019310", "GO:0050113"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0005737:cytoplasm:C", "GO:0019310:inositol catabolic process:P", "GO:0050113:inositol oxygenase activity:F"], "name": "Inositol_oxygenase", "pathway_ids": ["PWY-4841", "PWY-8142", "R-HSA-1855183", "R-BTA-1855183", "R-MMU-1855183", "R-DDI-1855183", "R-DRE-1855183", "R-RNO-1855183"], "pathways": ["PWY-4841:t:UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)", "PWY-8142:t:L-ascorbate biosynthesis VI (plants, myo-inositol pathway)", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-BTA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-DDI-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-DRE-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol"], "type": "Family"}, "IPR007829": {"description": "TM2 domain", "go_ids": [], "go_terms": [], "name": "TM2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007831": {"description": "Type II secretion system protein GspE, N-terminal", "go_ids": [], "go_terms": [], "name": "T2SS_GspE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007832": {"description": "RNA polymerase Rpc34", "go_ids": ["GO:0005666", "GO:0006383"], "go_terms": ["GO:0005666:RNA polymerase III complex:C", "GO:0006383:transcription by RNA polymerase III:P"], "name": "RNA_pol_Rpc34", "pathway_ids": ["R-SCE-76066", "R-DDI-76066", "R-HSA-76071", "R-DME-76066", "R-DDI-76061", "R-DME-76061", "R-SPO-76066", "R-HSA-76066", "R-MMU-76061", "R-HSA-73980", "R-SPO-76061", "R-MMU-76071", "R-HSA-76061", "R-HSA-1834949", "R-MMU-76066", "R-HSA-73780", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DME-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR007833": {"description": "Capsule polysaccharide biosynthesis", "go_ids": ["GO:0000271", "GO:0015774"], "go_terms": ["GO:0000271:polysaccharide biosynthetic process:P", "GO:0015774:polysaccharide transport:P"], "name": "Capsule_polysaccharide_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007834": {"description": "DSS1/SEM1", "go_ids": ["GO:0006406", "GO:0043248", "GO:0008541"], "go_terms": ["GO:0006406:mRNA export from nucleus:P", "GO:0043248:proteasome assembly:P", "GO:0008541:proteasome regulatory particle, lid subcomplex:C"], "name": "DSS1_SEM1", "pathway_ids": ["R-HSA-9020702", "R-HSA-174178", "R-HSA-9604323", "R-HSA-5693616", "R-HSA-5689880", "R-HSA-8951664", "R-HSA-9010553", "R-HSA-9932298", "R-HSA-75815", "R-HSA-9766229", "R-HSA-5676590", "R-HSA-9709570", "R-HSA-4641257", "R-HSA-9763198", "R-HSA-8854050", "R-HSA-174113", "R-HSA-450408", "R-HSA-5610783", "R-HSA-211733", "R-HSA-68867", "R-HSA-1234176", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-HSA-69481", "R-DME-432524", "R-HSA-8941858", "R-DME-209461", "R-HSA-5678895", "R-HSA-9755511", "R-HSA-4641258", "R-HSA-9709275", "R-HSA-180585", "R-HSA-1169091", "R-HSA-4608870", "R-HSA-5658442", "R-HSA-9704331", "R-HSA-180534", "R-HSA-8948751", "R-HSA-1236974", "R-HSA-5689603", "R-HSA-5693554", "R-DME-209406", "R-HSA-174154", "R-HSA-68949", "R-HSA-5610785", "R-HSA-187577", "R-HSA-2467813", "R-HSA-5685942", "R-HSA-349425", "R-HSA-9704646", "R-HSA-9824272", "R-HSA-174184", "R-HSA-2871837", "R-HSA-9907900", "R-HSA-9954709", "R-HSA-5362768", "R-DME-216167", "R-HSA-174084", "R-HSA-9762114", "R-HSA-5693568", "R-HSA-5607764", "R-HSA-9701192", "R-HSA-195253", "R-HSA-5610780", "R-DME-209360", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-DME-432626", "R-HSA-983168", "R-HSA-5632684", "R-DME-538864", "R-HSA-8939902", "R-HSA-5668541", "R-HSA-9929356", "R-HSA-5687128", "R-DME-432395", "R-HSA-69017", "R-HSA-350562", "R-HSA-5693579", "R-HSA-202424", "R-HSA-8939236", "R-HSA-5358346"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9766229:r:Degradation of CDH1", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-9763198:r:Impaired BRCA2 binding to SEM1 (DSS1)", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-432524:r:Degradation of PER", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-9709275:r:Impaired BRCA2 translocation to the nucleus", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-9824272:r:Somitogenesis", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9907900:r:Proteasome assembly", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DME-216167:r:Nuclear CI is degraded", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-432626:r:Circadian Clock pathway", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DME-538864:r:Degradation of CRY", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-432395:r:Degradation of TIM", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Family"}, "IPR007835": {"description": "MOFRL domain", "go_ids": [], "go_terms": [], "name": "MOFRL", "pathway_ids": ["R-HSA-70350", "R-BTA-70350", "R-RNO-70350", "R-DME-70350", "R-DRE-70350", "R-CEL-70350", "R-MMU-70350"], "pathways": ["R-HSA-70350:r:Fructose catabolism", "R-BTA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-DME-70350:r:Fructose catabolism", "R-DRE-70350:r:Fructose catabolism", "R-CEL-70350:r:Fructose catabolism", "R-MMU-70350:r:Fructose catabolism"], "type": "Domain"}, "IPR007836": {"description": "Large ribosomal subunit protein eS32", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eS32", "pathway_ids": ["R-HSA-1799339", "R-HSA-2408557", "R-HSA-9954716", "R-HSA-9010553", "R-HSA-156902", "R-HSA-72706", "R-HSA-72689", "R-HSA-156827", "R-HSA-72764", "R-HSA-192823", "R-HSA-975956", "R-HSA-975957", "R-HSA-9954709", "R-HSA-6791226", "R-HSA-9954714", "R-HSA-9633012"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-HSA-192823:r:Viral mRNA Translation", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR007837": {"description": "DNA damage-inducible protein DinB", "go_ids": [], "go_terms": [], "name": "DinB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007838": {"description": "Cell division protein ZapA-like", "go_ids": [], "go_terms": [], "name": "Cell_div_ZapA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007839": {"description": "GTP cyclohydrolase III", "go_ids": ["GO:0009058", "GO:0043740"], "go_terms": ["GO:0009058:biosynthetic process:P", "GO:0043740:GTP cyclohydrolase IIa activity:F"], "name": "GTP_CycHdrlase_3", "pathway_ids": ["PWY-6167"], "pathways": ["PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Family"}, "IPR007841": {"description": "Uncharacterised protein family UPF0210", "go_ids": [], "go_terms": [], "name": "UPF0210", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007842": {"description": "HEPN domain", "go_ids": [], "go_terms": [], "name": "HEPN_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007844": {"description": "AsmA", "go_ids": [], "go_terms": [], "name": "AsmA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007845": {"description": "Haemin-degrading HemS/ChuX domain", "go_ids": ["GO:0006826"], "go_terms": ["GO:0006826:iron ion transport:P"], "name": "HemS/ChuX_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007846": {"description": "RNA-recognition motif (RRM) Nup35-type domain", "go_ids": [], "go_terms": [], "name": "RRM_NUP35_dom", "pathway_ids": ["R-CEL-159231", "R-HSA-180910", "R-RNO-9615933", "R-DRE-3232142", "R-CEL-3301854", "R-CEL-159227", "R-RNO-3301854", "R-DRE-4551638", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-9615933", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-RNO-191859", "R-CEL-159230", "R-HSA-3371453", "R-CEL-4551638", "R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", 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"R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Conserved_site"}, "IPR007859": {"description": "ETF-QO/FixX, C-terminal domain", "go_ids": ["GO:0051536"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F"], "name": "ETF-QO/FixX_C", "pathway_ids": ["R-SSC-611105", "R-RNO-611105", "R-HSA-611105", "R-DDI-611105", "R-CEL-611105", "R-MMU-611105", "R-SPO-611105", "R-SCE-611105", "R-DME-611105"], "pathways": ["R-SSC-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-DDI-611105:r:Respiratory electron transport", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-DME-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR007860": {"description": "DNA mismatch repair protein MutS, connector domain", "go_ids": ["GO:0005524", "GO:0006298", "GO:0030983"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006298:mismatch repair:P", "GO:0030983:mismatched DNA binding:F"], "name": "DNA_mmatch_repair_MutS_con_dom", "pathway_ids": ["R-BTA-5358606", "R-RNO-5358565", "R-SPO-5358565", "R-HSA-5632927", "R-HSA-5358606", "R-DDI-5358565", "R-SCE-5358606", "R-HSA-6796648", "R-DME-5358565", "R-HSA-5632928", "R-HSA-5632968", "R-BTA-5358565", "R-SCE-5358565", "R-HSA-912446", "R-SPO-5358606", "R-HSA-5358565", "R-MMU-5358606", "R-MMU-5358565"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "type": "Domain"}, "IPR007861": {"description": "DNA mismatch repair protein MutS, clamp", "go_ids": ["GO:0005524", "GO:0006298", "GO:0030983"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006298:mismatch repair:P", "GO:0030983:mismatched DNA binding:F"], "name": "DNA_mismatch_repair_MutS_clamp", "pathway_ids": ["R-BTA-5358606", "R-RNO-5358565", "R-SPO-5358565", "R-HSA-5632927", "R-HSA-5358606", "R-DDI-5358565", "R-SCE-5358606", "R-HSA-6796648", "R-DME-5358565", "R-HSA-5632928", "R-HSA-5632968", "R-BTA-5358565", "R-SCE-5358565", "R-HSA-912446", "R-SPO-5358606", "R-HSA-5358565", "R-MMU-5358606", "R-MMU-5358565"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "type": "Domain"}, "IPR007862": {"description": "Adenylate kinase, active site lid domain", "go_ids": ["GO:0004017"], "go_terms": ["GO:0004017:AMP kinase activity:F"], "name": "Adenylate_kinase_lid-dom", "pathway_ids": ["PWY-7219", "R-CEL-983231", "R-DDI-983231", "R-PFA-499943", "R-XTR-499943", "R-HSA-983231", "R-SCE-499943", "R-MMU-983231", "R-SPO-499943", "R-HSA-499943", "R-BTA-983231", "R-MMU-499943", "R-DRE-499943", "R-DME-499943", "R-RNO-983231", "R-BTA-499943", "R-CEL-499943", "R-DME-983231", "R-SCE-983231", "R-DDI-499943", "R-RNO-499943"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DDI-983231:r:Factors involved in megakaryocyte development and platelet production", "R-PFA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-XTR-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Domain"}, "IPR007863": {"description": "Peptidase M16, C-terminal", "go_ids": [], "go_terms": [], "name": "Peptidase_M16_C", "pathway_ids": ["R-MMU-9837999", "R-DDI-611105", "R-BTA-5689880", "R-HSA-5689880", "R-HSA-77387", "R-CEL-9865881", "R-RNO-8949664", "R-MMU-8949664", "R-MMU-9865881", "R-BTA-9033241", "R-MMU-5689880", "R-RNO-9033241", "R-HSA-1268020", "R-BTA-9837999", "R-MMU-1268020", "R-SCE-9033241", "R-MMU-611105", "R-SPO-611105", "R-HSA-8949664", "R-HSA-9837999", "R-BTA-9865881", "R-SCE-1268020", "R-DDI-9033241", "R-DDI-9837999", "R-MMU-77387", "R-HSA-9865881", "R-BTA-8949664", "R-DRE-1268020", "R-CEL-9837999", "R-DME-9033241", "R-XTR-1268020", "R-RNO-9837999", "R-MMU-9033241", "R-SPO-1268020", "R-RNO-77387", "R-RNO-5689880", "R-SCE-9865878", "R-RNO-611105", "R-SPO-9033241", "R-HSA-611105", "R-SPO-9837999", "R-SCE-9837999", "R-CEL-611105", "R-CEL-8949664", "R-RNO-9865881", "R-SCE-611105", "R-BTA-77387", "R-DME-1268020", "R-HSA-9033241", "R-DME-5689880", "R-BTA-611105"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-611105:r:Respiratory electron transport", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-77387:r:Insulin receptor recycling", "R-CEL-9865881:r:Complex III assembly", "R-RNO-8949664:r:Processing of SMDT1", "R-MMU-8949664:r:Processing of SMDT1", "R-MMU-9865881:r:Complex III assembly", "R-BTA-9033241:r:Peroxisomal protein import", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-1268020:r:Mitochondrial protein import", "R-SCE-9033241:r:Peroxisomal protein import", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-HSA-8949664:r:Processing of SMDT1", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-9865881:r:Complex III assembly", "R-SCE-1268020:r:Mitochondrial protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-9865881:r:Complex III assembly", "R-BTA-8949664:r:Processing of SMDT1", "R-DRE-1268020:r:Mitochondrial protein import", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DME-9033241:r:Peroxisomal protein import", "R-XTR-1268020:r:Mitochondrial protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-SPO-1268020:r:Mitochondrial protein import", "R-RNO-77387:r:Insulin receptor recycling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-611105:r:Respiratory electron transport", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-611105:r:Respiratory electron transport", "R-CEL-8949664:r:Processing of SMDT1", "R-RNO-9865881:r:Complex III assembly", "R-SCE-611105:r:Respiratory electron transport", "R-BTA-77387:r:Insulin receptor recycling", "R-DME-1268020:r:Mitochondrial protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-5689880:r:Ub-specific processing proteases", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR007864": {"description": "Urease accessory protein UreE, C-terminal domain", "go_ids": ["GO:0065003", "GO:0016151", "GO:0019627"], "go_terms": ["GO:0065003:protein-containing complex assembly:P", "GO:0016151:nickel cation binding:F", "GO:0019627:urea metabolic process:P"], "name": "UreE_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007865": {"description": "Aminopeptidase P, N-terminal", "go_ids": ["GO:0030145", "GO:0070006"], "go_terms": ["GO:0030145:manganese ion binding:F", "GO:0070006:metalloaminopeptidase activity:F"], "name": "Aminopep_P_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007866": {"description": "TRIC channel", "go_ids": ["GO:0016020", "GO:0042802", "GO:0005267", "GO:0071805"], "go_terms": ["GO:0016020:membrane:C", "GO:0042802:identical protein binding:F", "GO:0005267:potassium channel activity:F", "GO:0071805:potassium ion transmembrane transport:P"], "name": "TRIC_channel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007867": {"description": "Glucose-methanol-choline oxidoreductase, C-terminal", "go_ids": ["GO:0016614"], "go_terms": ["GO:0016614:oxidoreductase activity, acting on CH-OH group of donors:F"], "name": "GMC_OxRtase_C", "pathway_ids": ["R-RNO-6798163", "R-HSA-6798163", "R-MMU-6798163"], "pathways": ["R-RNO-6798163:r:Choline catabolism", "R-HSA-6798163:r:Choline catabolism", "R-MMU-6798163:r:Choline catabolism"], "type": "Domain"}, "IPR007868": {"description": "Hom-end-associated Hint", "go_ids": ["GO:0030908"], "go_terms": ["GO:0030908:protein splicing:P"], "name": "Hom_end_hint", "pathway_ids": ["R-SCE-917977", "R-SCE-1222556", "R-SCE-77387", "R-SCE-9639288"], "pathways": ["R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR007869": {"description": "Homing endonuclease PI-Sce", "go_ids": ["GO:0003677", "GO:0004519", "GO:0030908"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004519:endonuclease activity:F", "GO:0030908:protein splicing:P"], "name": "Homing_endonuc_PI-Sce", "pathway_ids": ["R-SCE-917977", "R-SCE-1222556", "R-SCE-77387", "R-SCE-9639288"], "pathways": ["R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR007871": {"description": "Methyltransferase TRM13", "go_ids": ["GO:0008033", "GO:0008168"], "go_terms": ["GO:0008033:tRNA processing:P", "GO:0008168:methyltransferase activity:F"], "name": "Methyltransferase_TRM13", "pathway_ids": ["PWY-6829", "R-HSA-6782315"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR007872": {"description": "DPH-type metal-binding domain", "go_ids": [], "go_terms": [], "name": "DPH_MB_dom", "pathway_ids": ["R-DME-5358493", "R-SPO-5358493", "R-SCE-5358493", "R-BTA-5358493", "R-CEL-5358493", "R-HSA-5358493", "R-MMU-5358493"], "pathways": ["R-DME-5358493:r:Synthesis of diphthamide-EEF2", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Domain"}, "IPR007873": {"description": "Glycosyltransferase, ALG3", "go_ids": ["GO:0000030"], "go_terms": ["GO:0000030:mannosyltransferase activity:F"], "name": "Glycosyltransferase_ALG3", "pathway_ids": ["R-SCE-446193", "R-MMU-446193", "R-DME-446193", "R-SPO-446193", "R-HSA-446193", "R-DDI-446193", "R-HSA-4720475"], "pathways": ["R-SCE-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DME-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DDI-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-4720475:r:Defective ALG3 causes CDG-1d"], "type": "Family"}, "IPR007874": {"description": "Septum formation inhibitor MinC, N-terminal", "go_ids": ["GO:0051302"], "go_terms": ["GO:0051302:regulation of cell division:P"], "name": "MinC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007875": {"description": "Sprouty", "go_ids": ["GO:0007275", "GO:0009966", "GO:0016020"], "go_terms": ["GO:0007275:multicellular organism development:P", "GO:0009966:regulation of signal transduction:P", "GO:0016020:membrane:C"], "name": "Sprouty", "pathway_ids": ["R-DRE-5658623", "R-MMU-182971", "R-HSA-182971", "R-BTA-182971", "R-BTA-1295596", "R-RNO-5658623", "R-MMU-1295596", "R-HSA-5658442", "R-HSA-1295596", "R-DRE-5658442", "R-RNO-5658442", "R-GGA-182971", "R-MMU-5658442", "R-DME-182971", "R-DME-1295596", "R-MMU-5658623", "R-HSA-6802953", "R-HSA-5658623", "R-GGA-1295596"], "pathways": ["R-DRE-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-MMU-182971:r:EGFR downregulation", "R-HSA-182971:r:EGFR downregulation", "R-BTA-182971:r:EGFR downregulation", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-RNO-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-GGA-182971:r:EGFR downregulation", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-DME-182971:r:EGFR downregulation", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-MMU-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-HSA-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-GGA-1295596:r:Spry regulation of FGF signaling"], "type": "Family"}, "IPR007876": {"description": "Neuraminyllactose-binding hemagglutinin", "go_ids": ["GO:0009279"], "go_terms": ["GO:0009279:cell outer membrane:C"], "name": "NeuraminylLac-bd_hemagglutn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007877": {"description": "Protein of unknown function DUF707", "go_ids": [], "go_terms": [], "name": "DUF707", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007878": {"description": "Coronavirus NS2A", "go_ids": [], "go_terms": [], "name": "Coronavirus_NS2A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007879": {"description": "FAD-linked sulfhydryl oxidase", "go_ids": [], "go_terms": [], "name": "Baculo_p33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007880": {"description": "Spiralin, C-terminal domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Spiralin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007881": {"description": "UNC-50", "go_ids": [], "go_terms": [], "name": "UNC-50", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007882": {"description": "Microtubule-associated protein 6", "go_ids": ["GO:0005516", "GO:0008017", "GO:0005874", "GO:0000226"], "go_terms": ["GO:0005516:calmodulin binding:F", "GO:0008017:microtubule binding:F", "GO:0005874:microtubule:C", "GO:0000226:microtubule cytoskeleton organization:P"], "name": "MAP6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007883": {"description": "Protein of unknown function DUF713", "go_ids": [], "go_terms": [], "name": "DUF713", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007884": {"description": "Protein-L-histidine N-pros-methyltransferase", "go_ids": ["GO:0106370"], "go_terms": ["GO:0106370:protein-L-histidine N-pros-methyltransferase activity:F"], "name": "METL9", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR007885": {"description": "MgpC adhesin", "go_ids": [], "go_terms": [], "name": "MgpC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007886": {"description": "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal", "go_ids": [], "go_terms": [], "name": "AlaDH/PNT_N", "pathway_ids": ["R-BTA-71403", "R-MMU-71064", "R-BTA-71064", "R-MMU-71403", "R-RNO-71064", "R-HSA-71403", "R-HSA-71064"], "pathways": ["R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-71064:r:Lysine catabolism", "R-BTA-71064:r:Lysine catabolism", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71064:r:Lysine catabolism", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71064:r:Lysine catabolism"], "type": "Domain"}, "IPR007887": {"description": "Penicillin-binding protein 3-like, N-terminal domain", "go_ids": ["GO:0046677"], "go_terms": ["GO:0046677:response to antibiotic:P"], "name": "MecA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007889": {"description": "DNA binding HTH domain, Psq-type", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "HTH_Psq", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007890": {"description": "CHASE2", "go_ids": [], "go_terms": [], "name": "CHASE2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007891": {"description": "CHASE3", "go_ids": [], "go_terms": [], "name": "CHASE3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007892": {"description": "CHASE4", "go_ids": [], "go_terms": [], "name": "CHASE4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007893": {"description": "Spore coat protein U/FanG", "go_ids": [], "go_terms": [], "name": "Spore_coat_U/FanG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007894": {"description": "MASE2", "go_ids": [], "go_terms": [], "name": "MASE2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007895": {"description": "MASE1", "go_ids": [], "go_terms": [], "name": "MASE1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007896": {"description": "Chlorhexidine efflux transporter", "go_ids": [], "go_terms": [], "name": "BTP_bacteria", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007897": {"description": "PHB accumulation regulatory", "go_ids": [], "go_terms": [], "name": "PHB_accumulat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007898": {"description": "RNA polymerase I-specific transcription initiation factor Rrn10, Saccharomycetes", "go_ids": ["GO:0001165", "GO:0042790", "GO:0000500"], "go_terms": ["GO:0001165:RNA polymerase I cis-regulatory region sequence-specific DNA binding:F", "GO:0042790:nucleolar large rRNA transcription by RNA polymerase I:P", "GO:0000500:RNA polymerase I upstream activating factor complex:C"], "name": "Rrn10_Saccharomycetes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007899": {"description": "CHAD domain", "go_ids": [], "go_terms": [], "name": "CHAD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007900": {"description": "Transcription initiation factor TFIID component TAF4, C-terminal", "go_ids": ["GO:0005669", "GO:0006352"], "go_terms": ["GO:0005669:transcription factor TFIID complex:C", "GO:0006352:DNA-templated transcription initiation:P"], "name": "TAF4_C", "pathway_ids": ["R-CEL-73779", "R-MMU-75953", "R-SCE-75953", "R-DME-76042", "R-MMU-6804756", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-HSA-73776", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-DME-75953", "R-MMU-73779", "R-CEL-73776", "R-HSA-167172", "R-MMU-76042", "R-SCE-73779", "R-DME-674695", "R-MMU-674695", "R-DME-6804756", "R-SCE-76042", "R-HSA-167161", "R-CEL-674695", "R-HSA-6804756", "R-SCE-674695", "R-HSA-674695", "R-HSA-76042", "R-CEL-76042", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR007902": {"description": "Centromere protein Chl4/mis15/CENP-N", "go_ids": ["GO:0034080", "GO:0007059"], "go_terms": ["GO:0034080:CENP-A containing chromatin assembly:P", "GO:0007059:chromosome segregation:P"], "name": "Chl4/mis15/CENP-N", "pathway_ids": ["R-HSA-606279", "R-XTR-9648025", "R-RNO-68877", "R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-RNO-2500257", "R-RNO-606279", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-MMU-606279", "R-HSA-9648025", "R-XTR-68877", "R-MMU-68877", "R-RNO-5663220", "R-GGA-2500257", "R-GGA-141444", "R-XTR-141444", "R-XTR-606279", "R-HSA-68877", "R-GGA-9648025", "R-GGA-606279", "R-GGA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-GGA-2467813", "R-MMU-9648025", "R-XTR-2500257", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR007905": {"description": "Emopamil-binding protein", "go_ids": ["GO:0016020", "GO:0016125", "GO:0047750"], "go_terms": ["GO:0016020:membrane:C", "GO:0016125:sterol metabolic process:P", "GO:0047750:cholestenol delta-isomerase activity:F"], "name": "EBP", "pathway_ids": ["R-DDI-9969901", "R-HSA-6807047", "R-MMU-9969901", "R-HSA-9969901", "R-MMU-6807047", "R-RNO-6807047", "R-DDI-6807047", "R-RNO-9969901"], "pathways": ["R-DDI-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-HSA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-HSA-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-MMU-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-DDI-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "type": "Family"}, "IPR007906": {"description": "Glycosylation-dependent cell adhesion molecule 1", "go_ids": [], "go_terms": [], "name": "GLYCAM-1", "pathway_ids": ["R-HSA-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR007908": {"description": "Outer membrane protein 2, Brucella", "go_ids": [], "go_terms": [], "name": "OMP2_Brucella", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007910": {"description": "Protein of unknown function DUF735", "go_ids": [], "go_terms": [], "name": "DUF735", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007912": {"description": "Adenovirus E3A", "go_ids": [], "go_terms": [], "name": "Adeno_E3A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007914": {"description": "Uncharacterised protein family UPF0193", "go_ids": [], "go_terms": [], "name": "UPF0193", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007915": {"description": "Oligosaccharyltransferase complex subunit", "go_ids": ["GO:0008250"], "go_terms": ["GO:0008250:oligosaccharyltransferase complex:C"], "name": "TMEM258/Ost5", "pathway_ids": ["R-MMU-9931295", "R-GGA-9931295", "R-BTA-9931295", "R-HSA-446203", "R-DRE-9768727", "R-HSA-9694548", "R-HSA-9918432", "R-BTA-9768727", "R-HSA-9768727", "R-MMU-9768727", "R-GGA-9768727", "R-HSA-9931295"], "pathways": ["R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-GGA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-GGA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Family"}, "IPR007918": {"description": "Mitochondrial distribution/morphology family 35/apoptosis", "go_ids": [], "go_terms": [], "name": "MDM35_apoptosis", "pathway_ids": ["R-HSA-9837999", "R-MMU-6803204", "R-SCE-6803204", "R-HSA-6803204", "R-SPO-6803204"], "pathways": ["R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-SCE-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-SPO-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "type": "Family"}, "IPR007919": {"description": "Uncharacterised protein family UPF0220", "go_ids": [], "go_terms": [], "name": "UPF0220", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007920": {"description": "Protein of unknown function UPF0223", "go_ids": [], "go_terms": [], "name": "UPF0223", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007921": {"description": "CHAP domain", "go_ids": [], "go_terms": [], "name": "CHAP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007922": {"description": "DciA-like", "go_ids": [], "go_terms": [], "name": "DciA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007923": {"description": "Herpesvirus glycoprotein L, N-terminal", "go_ids": [], "go_terms": [], "name": "Herpes_gL_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007925": {"description": "Relaxosome protein TraM", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "TRelaxosome_TraM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007926": {"description": "Adhesin Lsa63/Borrelia P83100", "go_ids": [], "go_terms": [], "name": "Adhesin_Lsa63/Borrelia_P83", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007927": {"description": "Protein of unknown function DUF722", "go_ids": [], "go_terms": [], "name": "DUF722", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007928": {"description": "Antifreeze, Choristoneura fumiferana", "go_ids": [], "go_terms": [], "name": "Antifreeze_CF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007929": {"description": "Protein of unknown function DUF723", "go_ids": [], "go_terms": [], "name": "DUF723", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007930": {"description": "Protein of unknown function DUF724", "go_ids": [], "go_terms": [], "name": "DUF724", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007931": {"description": "Protein TsetseEP", "go_ids": [], "go_terms": [], "name": "TsetseEP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007932": {"description": "Receptor-recognising protein Gp38", "go_ids": [], "go_terms": [], "name": "Receptor-recog_Gp38", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007933": {"description": "Transcription activator CII", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Transcrpt_activ_CII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007934": {"description": "Alpha-L-arabinofuranosidase B, arabinose-binding domain", "go_ids": ["GO:0046373", "GO:0046556"], "go_terms": ["GO:0046373:L-arabinose metabolic process:P", "GO:0046556:alpha-L-arabinofuranosidase activity:F"], "name": "AbfB_ABD", "pathway_ids": ["R-HSA-9662361"], "pathways": ["R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR007935": {"description": "Tobravirus 2B", "go_ids": [], "go_terms": [], "name": "Tobravirus_2B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007936": {"description": "Virulence-associated protein E-like domain", "go_ids": [], "go_terms": [], "name": "VapE-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007937": {"description": "RNA polymerase, 22kDa subunit, poxviral", "go_ids": ["GO:0003677", "GO:0003899", "GO:0019083"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0019083:viral transcription:P"], "name": "RNA_Pol_22kDa_poxvir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007938": {"description": "Baculovirus occlusion-derived virus envelope, E25", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Baculo_ODV-E25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007939": {"description": "Copper resistance B precursor", "go_ids": ["GO:0005507", "GO:0006878", "GO:0009279"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0006878:intracellular copper ion homeostasis:P", "GO:0009279:cell outer membrane:C"], "name": "Cu-R_B_prcur", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007940": {"description": "SH3-binding 5", "go_ids": ["GO:0035556"], "go_terms": ["GO:0035556:intracellular signal transduction:P"], "name": "SH3BP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007941": {"description": "Protein of unknown function DUF726", "go_ids": [], "go_terms": [], "name": "DUF726", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007942": {"description": "Phospholipase-like", "go_ids": [], "go_terms": [], "name": "PLipase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007943": {"description": "Aspartyl beta-hydroxylase/Triadin domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Asp-B-hydro/Triadin_dom", "pathway_ids": ["R-RNO-2672351", "R-MMU-2672351", "R-BTA-5578775", "R-RNO-5578775", "R-HSA-5578775", "R-MMU-5578775", "R-HSA-2672351", "R-HSA-9629569", "R-BTA-2672351"], "pathways": ["R-RNO-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-BTA-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9629569:r:Protein hydroxylation", "R-BTA-2672351:r:Stimuli-sensing channels"], "type": "Domain"}, "IPR007944": {"description": "Flagellar transcriptional activator FlhC", "go_ids": ["GO:0003677", "GO:0045893", "GO:1902208"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0045893:positive regulation of DNA-templated transcription:P", "GO:1902208:regulation of bacterial-type flagellum assembly:P"], "name": "FlhC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007945": {"description": "Neuroendocrine 7B2 precursor", "go_ids": ["GO:0007218", "GO:0030141"], "go_terms": ["GO:0007218:neuropeptide signaling pathway:P", "GO:0030141:secretory granule:C"], "name": "Secretogranin_V", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007946": {"description": "A1 cistron-splicing factor, AAR2", "go_ids": [], "go_terms": [], "name": "AAR2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007947": {"description": "CD164-related protein", "go_ids": [], "go_terms": [], "name": "CD164_MGC24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007948": {"description": "Protein of unknown function DUF736", "go_ids": [], "go_terms": [], "name": "DUF736", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007949": {"description": "SDA1, middle domain", "go_ids": [], "go_terms": [], "name": "SDA1_MD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007951": {"description": "Keratin-associated protein, PMG type", "go_ids": [], "go_terms": [], "name": "KRTAP_PMG", "pathway_ids": ["R-HSA-6805567"], "pathways": ["R-HSA-6805567:r:Keratinization"], "type": "Family"}, "IPR007952": {"description": "Poxvirus A2.5L", "go_ids": [], "go_terms": [], "name": "Poxvirus_A2.5L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007953": {"description": "Holin-like, BlyB", "go_ids": [], "go_terms": [], "name": "Holin-like_BlyB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007954": {"description": "Baculovirus immediate-early", "go_ids": [], "go_terms": [], "name": "Baculo_IE-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007955": {"description": "Bystin", "go_ids": [], "go_terms": [], "name": "Bystin", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-RNO-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR007956": {"description": "Malonyl-CoA decarboxylase, C-terminal", "go_ids": ["GO:0006633", "GO:0050080"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P", "GO:0050080:malonyl-CoA decarboxylase activity:F"], "name": "Malonyl_CoA_deC_C", "pathway_ids": ["PWY-7485", "PWY-8358", "R-RNO-390247", "R-RNO-9033241", "R-MMU-9033241", "R-HSA-9033241", "R-HSA-390247", "R-MMU-390247"], "pathways": ["PWY-7485:t:tetracenomycin C biosynthesis", "PWY-8358:t:curacin A biosynthesis", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR007957": {"description": "African swine fever virus L11L", "go_ids": [], "go_terms": [], "name": "ASFV_L11L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007958": {"description": "Scorpion short chain toxin, chloride channel inhibitor", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Scorpion_toxinS_Cl_inh", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007959": {"description": "Dinoflagellate luciferase, N-terminal", "go_ids": [], "go_terms": [], "name": "Dino_Luciferase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007960": {"description": "Taste receptor type 2", "go_ids": ["GO:0004930", "GO:0007186", "GO:0016020", "GO:0050909", "GO:0033038"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F", "GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C", "GO:0050909:sensory perception of taste:P", "GO:0033038:bitter taste receptor activity:F"], "name": "TAS2R", "pathway_ids": ["R-HSA-9717207", "R-HSA-418594", "R-MMU-9717207", "R-RNO-9717207", "R-MMU-420499", "R-HSA-420499", "R-RNO-420499", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR007961": {"description": "Herpesvirus latent membrane 1", "go_ids": ["GO:0016020", "GO:0019087"], "go_terms": ["GO:0016020:membrane:C", "GO:0019087:symbiont-mediated transformation of host cell:P"], "name": "Herpes_LMP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007962": {"description": "Bombinin", "go_ids": ["GO:0005576", "GO:0042742"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042742:defense response to bacterium:P"], "name": "Bombinin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007963": {"description": "Peptidase M61, catalytic domain", "go_ids": [], "go_terms": [], "name": "Peptidase_M61_catalytic", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007964": {"description": "MICOS complex subunit MIC19/MIC25", "go_ids": ["GO:0061617", "GO:0005739"], "go_terms": ["GO:0061617:MICOS complex:C", "GO:0005739:mitochondrion:C"], "name": "MIC19/MIC25", "pathway_ids": ["R-HSA-1268020", "R-HSA-8949613"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-8949613:r:Cristae formation"], "type": "Family"}, "IPR007965": {"description": "Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type", "go_ids": ["GO:0019799", "GO:0005874", "GO:0071929"], "go_terms": ["GO:0019799:tubulin N-acetyltransferase activity:F", "GO:0005874:microtubule:C", "GO:0071929:alpha-tubulin acetylation:P"], "name": "GNAT_ATAT", "pathway_ids": ["R-MMU-5620920", "R-RNO-5620920", "R-HSA-5620920"], "pathways": ["R-MMU-5620920:r:Cargo trafficking to the periciliary membrane", "R-RNO-5620920:r:Cargo trafficking to the periciliary membrane", "R-HSA-5620920:r:Cargo trafficking to the periciliary membrane"], "type": "Domain"}, "IPR007966": {"description": "Protein of unknown function DUF720", "go_ids": [], "go_terms": [], "name": "DUF720", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007967": {"description": "GSKIP domain", "go_ids": [], "go_terms": [], "name": "GSKIP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007968": {"description": "Tobacco rattle virus, 16 kDa protein", "go_ids": [], "go_terms": [], "name": "Tobacco_rattle_virus_16kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007969": {"description": "Domain of unknown function DUF732", "go_ids": [], "go_terms": [], "name": "DUF732", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR007970": {"description": "Protein of unknown function DUF733", "go_ids": [], "go_terms": [], "name": "DUF733", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007971": {"description": "Major structural subunit of bundle-forming pilus", "go_ids": ["GO:0009289"], "go_terms": ["GO:0009289:pilus:C"], "name": "Bundlin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007972": {"description": "Mitochondrial fission regulator 1", "go_ids": [], "go_terms": [], "name": "Mtfr1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007973": {"description": "Pilus assembly TraE", "go_ids": [], "go_terms": [], "name": "Pilus_assembly_TraE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007974": {"description": "Tenuivirus movement protein", "go_ids": [], "go_terms": [], "name": "Tenui_movmnt_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007975": {"description": "Baculovirus pp39", "go_ids": [], "go_terms": [], "name": "Baculo_pp39", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007977": {"description": "Poxvirus Virion membrane protein OPG144 precursor", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Poxvirus_OPG144", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007978": {"description": "Baculovirus occlusion-derived virus envelope EC27", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Baculo_ODV-E27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007979": {"description": "Type II restriction enzyme NlaIII/ICEA1", "go_ids": [], "go_terms": [], "name": "NlaIII/ICEA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007980": {"description": "Small ribosomal subunit protein uS3m, fungi", "go_ids": ["GO:0003735", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0006412:translation:P"], "name": "Ribosomal_uS3m_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007981": {"description": "Peptidase A5, thermopsin", "go_ids": [], "go_terms": [], "name": "Peptidase_A5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007982": {"description": "Tombusvirus movement", "go_ids": [], "go_terms": [], "name": "Tombusvirus_movement", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007984": {"description": "DNA-directed RNA polymerase, 19kDa subunit, poxviral", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "DNA-dir_RNA_Pol_19kDa_poxvir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007985": {"description": "Haemolysin expression modulating, HHA", "go_ids": [], "go_terms": [], "name": "Hemolysn_expr_modulating_HHA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007986": {"description": "NINE", "go_ids": [], "go_terms": [], "name": "NINE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007987": {"description": "Poxvirus A21", "go_ids": [], "go_terms": [], "name": "Poxvirus_A21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007988": {"description": "Sperm-associated antigen 11 A/B", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Sperm_Ag_11A_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007989": {"description": "Protein of unknown function DUF730", "go_ids": [], "go_terms": [], "name": "DUF730", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007990": {"description": "Prolactin-inducible protein", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "PIP", "pathway_ids": ["R-HSA-5223345", "R-RNO-5223345", "R-MMU-5223345"], "pathways": ["R-HSA-5223345:r:Miscellaneous transport and binding events", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-MMU-5223345:r:Miscellaneous transport and binding events"], "type": "Family"}, "IPR007991": {"description": "RNA polymerase I specific transcription initiation factor RRN3", "go_ids": ["GO:0006361", "GO:0001181"], "go_terms": ["GO:0006361:transcription initiation at RNA polymerase I promoter:P", "GO:0001181:RNA polymerase I general transcription initiation factor activity:F"], "name": "RNA_pol_I_trans_ini_fac_RRN3", "pathway_ids": ["R-MMU-73762", "R-HSA-73772", "R-DME-73762", "R-SPO-73772", "R-SCE-73762", "R-MMU-73772", "R-HSA-73762", "R-CEL-73762", "R-DME-73772", "R-CEL-73772", "R-SCE-73772", "R-SPO-73762"], "pathways": ["R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-DME-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Family"}, "IPR007992": {"description": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS", "go_ids": ["GO:0005740", "GO:0016020"], "go_terms": ["GO:0005740:mitochondrial envelope:C", "GO:0016020:membrane:C"], "name": "CybS", "pathway_ids": ["R-XTR-71403", "R-HSA-611105", "R-HSA-71403", "R-HSA-9854311", "R-RNO-9854311", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-MMU-71403", "R-SCE-71403", "R-XTR-9854311", "R-DME-71403", "R-DRE-9854311", "R-RNO-71403", "R-GGA-71403", "R-DRE-71403"], "pathways": ["R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-GGA-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-71403:r:Citric acid cycle (TCA cycle)"], "type": "Family"}, "IPR007995": {"description": "Protein of unknown function DUF742", "go_ids": [], "go_terms": [], "name": "DUF742", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007996": {"description": "Vesivirus VP2", "go_ids": [], "go_terms": [], "name": "Vesivirus_VP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR007998": {"description": "Protein of unknown function DUF719", "go_ids": [], "go_terms": [], "name": "DUF719", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Family"}, "IPR007999": {"description": "Protein of unknown function DUF745", "go_ids": [], "go_terms": [], "name": "DUF745", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008000": {"description": "Rhamnose/fucose mutarotase", "go_ids": ["GO:0016857"], "go_terms": ["GO:0016857:racemase and epimerase activity, acting on carbohydrates and derivatives:F"], "name": "Rham/fucose_mutarotase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008001": {"description": "Macrophage colony stimulating factor-1", "go_ids": ["GO:0005125", "GO:0008083", "GO:0016020"], "go_terms": ["GO:0005125:cytokine activity:F", "GO:0008083:growth factor activity:F", "GO:0016020:membrane:C"], "name": "MCSF-1", "pathway_ids": ["R-MMU-9856649", "R-RNO-381426", "R-HSA-449836", "R-RNO-8957275", "R-RNO-9856649", "R-MMU-381426", "R-HSA-9856649", "R-HSA-8957275", "R-RNO-449836", "R-HSA-6783783", "R-MMU-8957275", "R-HSA-381426", "R-HSA-9680350", "R-MMU-449836"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-449836:r:Other interleukin signaling"], "type": "Family"}, "IPR008002": {"description": "Herpesvirus, Orf30", "go_ids": [], "go_terms": [], "name": "Herpes_Orf30", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008003": {"description": "Protein of unknown function DUF739", "go_ids": [], "go_terms": [], "name": "DUF739", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008004": {"description": "Protein OCTOPUS-like", "go_ids": [], "go_terms": [], "name": "OCTOPUS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008005": {"description": "Per os infectivity factor 6", "go_ids": [], "go_terms": [], "name": "PIF6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008006": {"description": "Peptidase M26, N-terminal domain", "go_ids": ["GO:0004222", "GO:0008270", "GO:0016020"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0008270:zinc ion binding:F", "GO:0016020:membrane:C"], "name": "Peptidase_M26_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008007": {"description": "Peptidase M42", "go_ids": [], "go_terms": [], "name": "Peptidase_M42", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008008": {"description": "Domain of unknown function DUF746", "go_ids": [], "go_terms": [], "name": "DUF746", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008010": {"description": "Tapt1 family", "go_ids": [], "go_terms": [], "name": "Tatp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008011": {"description": "Complex 1 LYR protein domain", "go_ids": ["GO:0005739"], "go_terms": ["GO:0005739:mitochondrion:C"], "name": "Complex1_LYR_dom", "pathway_ids": ["R-HSA-1362409", "R-HSA-9865881", "R-HSA-9854311", "R-BTA-9854311", "R-SCE-1362409", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198", "R-DRE-9865881", "R-DDI-1362409", "R-SCE-9865881", "R-MMU-9865881", "R-SPO-9865881", "R-RNO-9854311", "R-HSA-611105", "R-XTR-9865881", "R-MMU-9854311", "R-DDI-9865881", "R-MMU-1362409", "R-DRE-6799198", "R-MMU-611105", "R-RNO-9865881", "R-BTA-9865881", "R-BTA-1362409", "R-DME-1362409", "R-BTA-6799198", "R-SPO-1362409", "R-BTA-611105", "R-DME-9865881"], "pathways": ["R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9865881:r:Complex III assembly", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-9865881:r:Complex III assembly", "R-DDI-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SCE-9865881:r:Complex III assembly", "R-MMU-9865881:r:Complex III assembly", "R-SPO-9865881:r:Complex III assembly", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-611105:r:Respiratory electron transport", "R-XTR-9865881:r:Complex III assembly", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-9865881:r:Complex III assembly", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-9865881:r:Complex III assembly", "R-BTA-9865881:r:Complex III assembly", "R-BTA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DME-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-BTA-6799198:r:Complex I biogenesis", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR008012": {"description": "Proteasome maturation factor Ump1", "go_ids": ["GO:0043248"], "go_terms": ["GO:0043248:proteasome assembly:P"], "name": "Ump1", "pathway_ids": ["R-SCE-9907900", "R-MMU-9907900", "R-HSA-9907900", "R-SPO-9907900", "R-BTA-9907900", "R-DDI-9907900"], "pathways": ["R-SCE-9907900:r:Proteasome assembly", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-9907900:r:Proteasome assembly", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-9907900:r:Proteasome assembly"], "type": "Family"}, "IPR008013": {"description": "GATA-type transcription activator, N-terminal", "go_ids": ["GO:0003677", "GO:0005634", "GO:0008270", "GO:0045893"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0008270:zinc ion binding:F", "GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "GATA_N", "pathway_ids": ["R-HSA-2032785", "R-HSA-9925563", "R-HSA-983231", "R-HSA-9937080", "R-HSA-9925561", "R-RNO-5683826", "R-MMU-983231", "R-CFA-983231", "R-BTA-983231", "R-HSA-5578768", "R-HSA-5683826", "R-HSA-9823730", "R-RNO-983231", "R-HSA-9733709", "R-HSA-9758920", "R-HSA-9690406", "R-MMU-5683826", "R-HSA-400511"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CFA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-5578768:r:Physiological factors", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-9823730:r:Formation of definitive endoderm", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Domain"}, "IPR008014": {"description": "Glycogen synthase kinase-3 binding protein", "go_ids": [], "go_terms": [], "name": "GSK3-bd", "pathway_ids": ["R-MMU-196299", "R-HSA-196299", "R-MMU-4641262", "R-HSA-4641262"], "pathways": ["R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "type": "Family"}, "IPR008015": {"description": "GMP phosphodiesterase, delta subunit", "go_ids": [], "go_terms": [], "name": "PDED_dom", "pathway_ids": ["R-DRE-5624138", "R-HSA-5624958", "R-MMU-5624958", "R-BTA-5624958", "R-MMU-9648002", "R-CFA-9648002", "R-CFA-5624958", "R-MMU-5624138", "R-BTA-9648002", "R-HSA-5624138", "R-HSA-9648002", "R-CEL-5624138", "R-CEL-9648002", "R-DME-9648002"], "pathways": ["R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-BTA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-9648002:r:RAS processing", "R-CFA-9648002:r:RAS processing", "R-CFA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-BTA-9648002:r:RAS processing", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-9648002:r:RAS processing", "R-CEL-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-CEL-9648002:r:RAS processing", "R-DME-9648002:r:RAS processing"], "type": "Domain"}, "IPR008016": {"description": "Portal protein Gp10", "go_ids": [], "go_terms": [], "name": "Gp10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008017": {"description": "Delta-hexatoxin", "go_ids": ["GO:0005576", "GO:0019871"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019871:sodium channel inhibitor activity:F"], "name": "Delta-hexatoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008018": {"description": "Bacteriophage tail attachment protein FII", "go_ids": ["GO:0019068"], "go_terms": ["GO:0019068:virion assembly:P"], "name": "Phage_tail_attach_FII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008019": {"description": "Apolipoprotein C-II", "go_ids": ["GO:0006629", "GO:0006869", "GO:0008047", "GO:0042627"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0006869:lipid transport:P", "GO:0008047:enzyme activator activity:F", "GO:0042627:chylomicron:C"], "name": "Apo-CII", "pathway_ids": ["R-RNO-8963901", "R-MMU-8963888", "R-CFA-8963888", "R-CFA-975634", "R-HSA-8963889", "R-HSA-8964058", "R-BTA-8963901", "R-HSA-8963901", "R-HSA-8963888", "R-BTA-975634", "R-BTA-8963888", "R-MMU-8963901", "R-MMU-8964058", "R-RNO-8963888", "R-CFA-8963901", "R-MMU-975634", "R-RNO-975634", "R-HSA-9029569", "R-RNO-8964058", "R-HSA-975634", "R-BTA-8964058"], "pathways": ["R-RNO-8963901:r:Chylomicron remodeling", "R-MMU-8963888:r:Chylomicron assembly", "R-CFA-8963888:r:Chylomicron assembly", "R-CFA-975634:r:Retinoid metabolism and transport", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8964058:r:HDL remodeling", "R-BTA-8963901:r:Chylomicron remodeling", "R-HSA-8963901:r:Chylomicron remodeling", "R-HSA-8963888:r:Chylomicron assembly", "R-BTA-975634:r:Retinoid metabolism and transport", "R-BTA-8963888:r:Chylomicron assembly", "R-MMU-8963901:r:Chylomicron remodeling", "R-MMU-8964058:r:HDL remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-CFA-8963901:r:Chylomicron remodeling", "R-MMU-975634:r:Retinoid metabolism and transport", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-8964058:r:HDL remodeling", "R-HSA-975634:r:Retinoid metabolism and transport", "R-BTA-8964058:r:HDL remodeling"], "type": "Family"}, "IPR008020": {"description": "Capsid protein G8P", "go_ids": [], "go_terms": [], "name": "G8P", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008021": {"description": "Attachment protein G3P, N-terminal", "go_ids": [], "go_terms": [], "name": "Attachment_G3P_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008022": {"description": "DicB", "go_ids": [], "go_terms": [], "name": "DicB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008023": {"description": "Putative phospholipid transport protein EpaF", "go_ids": [], "go_terms": [], "name": "EpaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008024": {"description": "YiaAB two helix", "go_ids": [], "go_terms": [], "name": "YiaAB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008025": {"description": "CPI-17", "go_ids": ["GO:0005737", "GO:0042325"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0042325:regulation of phosphorylation:P"], "name": "CPI-17", "pathway_ids": ["R-RNO-5625740", "R-MMU-5625740", "R-HSA-5625740", "R-SSC-5625740"], "pathways": ["R-RNO-5625740:r:RHO GTPases activate PKNs", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-SSC-5625740:r:RHO GTPases activate PKNs"], "type": "Family"}, "IPR008026": {"description": "Herpesvirus ICP47", "go_ids": ["GO:0052031"], "go_terms": ["GO:0052031:symbiont-mediated perturbation of host defense response:P"], "name": "Herpes_ICP47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008027": {"description": "Cytochrome b-c1 complex subunit 9", "go_ids": ["GO:0006122"], "go_terms": ["GO:0006122:mitochondrial electron transport, ubiquinol to cytochrome c:P"], "name": "QCR9", "pathway_ids": ["R-SCE-9865878", "R-HSA-611105", "R-HSA-9865881", "R-DDI-611105", "R-MMU-611105", "R-SPO-611105", "R-BTA-9865881", "R-SCE-611105", "R-DME-9865881", "R-DME-611105", "R-BTA-611105", "R-MMU-9865881"], "pathways": ["R-SCE-9865878:r:Complex III assembly", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-9865881:r:Complex III assembly", "R-DDI-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-BTA-9865881:r:Complex III assembly", "R-SCE-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly"], "type": "Family"}, "IPR008028": {"description": "Sarcolipin", "go_ids": ["GO:0016020", "GO:0030234"], "go_terms": ["GO:0016020:membrane:C", "GO:0030234:enzyme regulator activity:F"], "name": "Sarcolipin", "pathway_ids": ["R-HSA-5578775", "R-HSA-936837"], "pathways": ["R-HSA-5578775:r:Ion homeostasis", "R-HSA-936837:r:Ion transport by P-type ATPases"], "type": "Family"}, "IPR008029": {"description": "Bacteriophage T7, Gp3, endodeoxynuclease I", "go_ids": ["GO:0008833", "GO:0015074", "GO:0016032"], "go_terms": ["GO:0008833:deoxyribonuclease IV (phage-T4-induced) activity:F", "GO:0015074:DNA integration:P", "GO:0016032:viral process:P"], "name": "Phage_T7_Gp3_endoDNaseI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008030": {"description": "NmrA-like domain", "go_ids": [], "go_terms": [], "name": "NmrA-like", "pathway_ids": ["R-MMU-70635", "R-RNO-611105", "R-MMU-6799198", "R-RNO-6799198", "R-BTA-70635", "R-MMU-611105", "R-HSA-70635", "R-HSA-9956520"], "pathways": ["R-MMU-70635:r:Urea cycle", "R-RNO-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-BTA-70635:r:Urea cycle", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-70635:r:Urea cycle", "R-HSA-9956520:r:ASS1 variants cause citrullinemia"], "type": "Domain"}, "IPR008031": {"description": "Monomethylamine methyltransferase MtmB", "go_ids": ["GO:0008168", "GO:0032259"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0032259:methylation:P"], "name": "MtmB_MeTrfase", "pathway_ids": ["PWY-5247"], "pathways": ["PWY-5247:t:methanogenesis from methylamine"], "type": "Family"}, "IPR008032": {"description": "Protein of unknown function DUF749", "go_ids": [], "go_terms": [], "name": "DUF749", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008034": {"description": "Delta-hemolysin", "go_ids": ["GO:0019836", "GO:0005576"], "go_terms": ["GO:0019836:symbiont-mediated hemolysis of host erythrocyte:P", "GO:0005576:extracellular region:C"], "name": "Delta_lysin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008035": {"description": "L-proline 3-hydroxylase, C-terminal", "go_ids": ["GO:0016706"], "go_terms": ["GO:0016706:2-oxoglutarate-dependent dioxygenase activity:F"], "name": "Pro_3_hydrox_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008036": {"description": "Conotoxin, mu-type", "go_ids": ["GO:0005576", "GO:0019871"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019871:sodium channel inhibitor activity:F"], "name": "Conotoxin_mu-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008037": {"description": "Pacifastin domain", "go_ids": ["GO:0030414"], "go_terms": ["GO:0030414:peptidase inhibitor activity:F"], "name": "Pacifastin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008040": {"description": "Hydantoinase/oxoprolinase, N-terminal", "go_ids": [], "go_terms": [], "name": "Hydant_A_N", "pathway_ids": ["R-HSA-5578998", "R-RNO-174403", "R-HSA-174403", "R-DDI-174403", "R-MMU-174403", "R-SCE-174403", "R-SPO-174403"], "pathways": ["R-HSA-5578998:r:Defective OPLAH causes OPLAHD", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-DDI-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling"], "type": "Domain"}, "IPR008041": {"description": "Peptidase C23", "go_ids": ["GO:0016817", "GO:0003968"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F", "GO:0003968:RNA-directed RNA polymerase activity:F"], "name": "Peptidase_C23", "pathway_ids": ["PWY-7045", "PWY-6915", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8075", "PWY-8437", "PWY-7706", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-5036", "PWY-6148", "PWY-8360", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-5035", "PWY-7693", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-8358", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-8104", "PWY-7419", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-8179", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8464", "PWY-6085", "PWY-8036", "PWY-6919", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-5070", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-8083", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-7232", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-5349", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7648", "PWY-7653", "PWY-6154", "PWY-601", "PWY-7649", "PWY-4161", "PWY-102", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-5047", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-8437:t:furaquinocin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8360:t:hectochlorin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-8358:t:curacin A biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-8104:t:yangonin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-8036:t:chaxamycin biosynthesis", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR008042": {"description": "Retrotransposon Pao-like, RNAseH-like domain", "go_ids": [], "go_terms": [], "name": "Retrotrans_Pao_RNase-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008043": {"description": "Peptidase C21", "go_ids": ["GO:0016032", "GO:0004197"], "go_terms": ["GO:0016032:viral process:P", "GO:0004197:cysteine-type endopeptidase activity:F"], "name": "Peptidase_C21", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7250", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR008044": {"description": "Bacteriophage lysin", "go_ids": [], "go_terms": [], "name": "Phage_lysin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008055": {"description": "Neurotensin/neuromedin N", "go_ids": ["GO:0005184", "GO:0005576"], "go_terms": ["GO:0005184:neuropeptide hormone activity:F", "GO:0005576:extracellular region:C"], "name": "NeurotensiN", "pathway_ids": ["R-MMU-416476", "R-CFA-375276", "R-RNO-375276", "R-HSA-375276", "R-CFA-416476", "R-MMU-375276", "R-HSA-416476", "R-RNO-416476", "R-BTA-375276", "R-BTA-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-CFA-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-CFA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-BTA-416476:r:G alpha (q) signalling events"], "type": "Family"}, "IPR008065": {"description": "Pro-FMRFamide-related neuropeptide FF", "go_ids": ["GO:0005184", "GO:0005102"], "go_terms": ["GO:0005184:neuropeptide hormone activity:F", "GO:0005102:signaling receptor binding:F"], "name": "NPFF", "pathway_ids": ["R-MMU-416476", "R-BTA-389397", "R-MMU-389397", "R-HSA-416476", "R-RNO-416476", "R-HSA-389397", "R-RNO-389397", "R-BTA-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-BTA-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-MMU-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-RNO-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-BTA-416476:r:G alpha (q) signalling events"], "type": "Family"}, "IPR008075": {"description": "Lipocalin-interacting membrane receptor", "go_ids": [], "go_terms": [], "name": "LIMR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008076": {"description": "Cyanate hydratase", "go_ids": ["GO:0009440", "GO:0008824"], "go_terms": ["GO:0009440:cyanate catabolic process:P", "GO:0008824:cyanate hydratase activity:F"], "name": "Cyanase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008080": {"description": "Parvalbumin", "go_ids": ["GO:0005509"], "go_terms": ["GO:0005509:calcium ion binding:F"], "name": "Parvalbumin", "pathway_ids": ["R-HSA-8986944"], "pathways": ["R-HSA-8986944:r:Transcriptional Regulation by MECP2"], "type": "Family"}, "IPR008081": {"description": "Cytoplasmic FMR1-interacting", "go_ids": ["GO:0031267", "GO:0030833"], "go_terms": ["GO:0031267:small GTPase binding:F", "GO:0030833:regulation of actin filament polymerization:P"], "name": "Cytoplasmic_FMR1-int", "pathway_ids": ["R-HSA-5663213", "R-HSA-6798695", "R-CEL-6798695", "R-DRE-2029482", "R-MMU-9013408", "R-DRE-9013404", "R-MMU-4420097", "R-MMU-9013404", "R-DDI-9013149", "R-CEL-9013149", "R-HSA-4420097", "R-HSA-9013423", "R-DME-2029482", "R-MMU-5663213", "R-DRE-6798695", "R-DRE-9013149", "R-DDI-9013423", "R-HSA-9013408", "R-CEL-9013423", "R-DME-5663213", "R-DDI-2029482", "R-DDI-6798695", "R-DRE-5663213", "R-HSA-9664422", "R-DME-9013149", "R-DRE-9013408", "R-DME-6798695", "R-DDI-5663213", "R-HSA-2029482", "R-CEL-5663213", "R-MMU-2029482", "R-CEL-2029482", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-MMU-6798695", "R-DDI-9013404", "R-MMU-9013149", "R-DME-4420097", "R-DME-9013423", "R-DRE-9013423"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-DRE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DRE-6798695:r:Neutrophil degranulation", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DRE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-9013408:r:RHOG GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR008083": {"description": "CD34 antigen", "go_ids": ["GO:0007155", "GO:0016020"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0016020:membrane:C"], "name": "CD34", "pathway_ids": ["R-HSA-198933", "R-MMU-198933", "R-CFA-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR008090": {"description": "Ferric iron reductase", "go_ids": [], "go_terms": [], "name": "Fe_iron_reduct", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008107": {"description": "Mycoplasma P48 major surface lipoprotein", "go_ids": [], "go_terms": [], "name": "Mycoplasma_p48", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008108": {"description": "Phosphatase IpgD/SopB", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "IpgD/SopB", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR008111": {"description": "RNA-binding motif protein 8", "go_ids": ["GO:0003723", "GO:0005634", "GO:0005737", "GO:0006396"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C", "GO:0006396:RNA processing:P"], "name": "RNA-bd_8", "pathway_ids": ["R-RNO-975957", "R-HSA-73856", "R-SPO-159236", "R-CEL-975957", "R-MMU-72163", "R-MMU-975957", "R-HSA-9010553", "R-MMU-73856", "R-XTR-159236", "R-RNO-72163", "R-XTR-72163", "R-SPO-975957", "R-CEL-73856", "R-DRE-975957", "R-DME-159236", "R-DME-72163", "R-HSA-72187", "R-MMU-159236", "R-RNO-73856", "R-XTR-975957", "R-DRE-72163", "R-DRE-159236", "R-HSA-72163", "R-HSA-975957", "R-DRE-73856", "R-MMU-72187", "R-RNO-159236", "R-DME-73856", "R-HSA-159236", "R-CEL-72163", "R-SPO-72163", "R-DME-975957", "R-CEL-159236"], "pathways": ["R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR008118": {"description": "Dense granule Gra2 protein", "go_ids": [], "go_terms": [], "name": "Gra2_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008119": {"description": "Dense granule Gra6 protein", "go_ids": [], "go_terms": [], "name": "Gra6_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008127": {"description": "Glycine receptor alpha", "go_ids": ["GO:0022824", "GO:0005886", "GO:0016594"], "go_terms": ["GO:0022824:transmitter-gated monoatomic ion channel activity:F", "GO:0005886:plasma membrane:C", "GO:0016594:glycine binding:F"], "name": "Glycine_rcpt_A", "pathway_ids": ["R-DRE-112314", "R-RNO-112314", "R-BTA-112314", "R-HSA-112314", "R-MMU-112314"], "pathways": ["R-DRE-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-RNO-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-BTA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-112314:r:Neurotransmitter receptors and postsynaptic signal transmission"], "type": "Family"}, "IPR008131": {"description": "Early E3 14.5kDa protein", "go_ids": ["GO:0009966", "GO:0016020"], "go_terms": ["GO:0009966:regulation of signal transduction:P", "GO:0016020:membrane:C"], "name": "Adeno_E3_14_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008135": {"description": "Competence-induced protein CinA", "go_ids": [], "go_terms": [], "name": "Competence-induced_CinA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008136": {"description": "CinA, C-terminal", "go_ids": [], "go_terms": [], "name": "CinA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008138": {"description": "Saposin B type, region 2", "go_ids": [], "go_terms": [], "name": "SapB_2", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-RNO-9840310", "R-HSA-5688031", "R-MMU-9840310", "R-HSA-375276", "R-HSA-9840310", "R-RNO-5683826", "R-MMU-375276", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-HSA-418594", "R-HSA-5688890", "R-HSA-5683826", "R-RNO-375276", "R-HSA-6803157", "R-MMU-6798695", "R-BTA-5683826", "R-MMU-5683826", "R-HSA-5688849", "R-MMU-114608"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-5688031:r:Defective pro-SFTPB causes SMDP1 and RDS", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-5683826:r:Surfactant metabolism", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR008139": {"description": "Saposin B type domain", "go_ids": [], "go_terms": [], "name": "SaposinB_dom", "pathway_ids": ["R-DDI-9840310", "R-HSA-6798695", "R-RNO-9840310", "R-HSA-5688031", "R-MMU-9840310", "R-DDI-6798695", "R-HSA-375276", "R-HSA-9840310", "R-RNO-5683826", "R-MMU-375276", "R-MMU-5683826", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-BTA-9840310", "R-HSA-418594", "R-HSA-5688890", "R-HSA-5683826", "R-RNO-375276", "R-CEL-9840310", "R-HSA-6803157", "R-MMU-6798695", "R-BTA-5683826", "R-DDI-8964038", "R-RNO-6798695", "R-HSA-5688849", "R-MMU-114608"], "pathways": ["R-DDI-9840310:r:Glycosphingolipid catabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-5688031:r:Defective pro-SFTPB causes SMDP1 and RDS", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-5683826:r:Surfactant metabolism", "R-DDI-8964038:r:LDL clearance", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR008141": {"description": "Alanine dehydrogenase", "go_ids": ["GO:0000286", "GO:0042853"], "go_terms": ["GO:0000286:L-alanine dehydrogenase (NAD+) activity:F", "GO:0042853:L-alanine catabolic process:P"], "name": "Ala_DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008145": {"description": "Guanylate kinase/L-type calcium channel beta subunit", "go_ids": [], "go_terms": [], "name": "GK/Ca_channel_bsu", "pathway_ids": ["PWY-7221", "PWY-8289", "R-HSA-9013409", "R-MMU-451308", "R-MMU-9013106", "R-RNO-2028269", "R-RNO-112308", "R-HSA-420029", "R-MMU-9013408", "R-RNO-9013149", "R-CEL-438066", "R-RNO-191650", "R-HSA-9856532", "R-HSA-351906", "R-MMU-9013404", "R-HSA-442982", "R-HSA-499943", "R-HSA-9013424", "R-BTA-5576892", "R-DRE-9013406", "R-RNO-212676", "R-CFA-451308", "R-CFA-8849932", "R-MMU-9013420", "R-HSA-5576893", "R-CEL-451308", "R-HSA-9662360", "R-MMU-5576893", "R-CFA-5673001", "R-RNO-9013404", "R-RNO-9013406", "R-HSA-9013408", "R-RNO-9013408", "R-HSA-9705677", "R-RNO-5673001", "R-MMU-5673001", "R-DME-438066", "R-HSA-447038", "R-DDI-499943", "R-HSA-373753", "R-RNO-5576892", "R-MMU-9748787", "R-BTA-5576893", "R-RNO-5682910", "R-HSA-451308", "R-MMU-8849932", "R-MMU-438066", "R-MMU-5625900", "R-MMU-351906", "R-HSA-400042", "R-XTR-9013408", "R-CEL-212676", "R-RNO-438066", "R-SPO-499943", "R-HSA-419037", "R-HSA-5673001", "R-HSA-9013404", "R-DRE-8849932", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-9696264", "R-XTR-9013404", "R-HSA-8935964", "R-HSA-9748787", "R-HSA-9620244", "R-HSA-8980692", "R-MMU-9013406", "R-BTA-9748787", "R-MMU-9013149", "R-MMU-5682910", "R-CFA-399719", "R-HSA-9013026", "R-MMU-9696264", "R-RNO-6794361", "R-HSA-112308", "R-HSA-9609736", "R-HSA-212676", "R-RNO-8849932", "R-DME-5625900", "R-DRE-9013423", "R-CEL-8849932", "R-HSA-5625900", "R-RNO-5576893", "R-DDI-9748787", "R-MMU-422356", "R-MMU-8980692", "R-HSA-191650", "R-RNO-351906", "R-DRE-438066", "R-BTA-9013406", "R-MMU-5576892", "R-DRE-9013404", "R-HSA-9013106", "R-HSA-8849932", "R-MMU-191650", "R-BTA-112308", "R-HSA-5576892", "R-HSA-6794361", "R-BTA-9013423", "R-MMU-499943", "R-HSA-9013423", "R-CEL-5625900", "R-XTR-9013423", "R-DRE-9013149", "R-HSA-9692912", "R-RNO-451308", "R-HSA-9617324", "R-MMU-112308", "R-HSA-9918481", "R-SCE-9748787", "R-HSA-399719", "R-XTR-8849932", "R-MMU-212676", "R-CEL-6794361", "R-HSA-3000170", "R-MMU-2028269", "R-DRE-9013408", "R-HSA-9013420", "R-HSA-9662361", "R-MMU-6794361", "R-HSA-9696270", "R-MMU-9013424", "R-SCE-499943", "R-RNO-399719", "R-DME-212676", "R-DME-451308", "R-HSA-1236394", "R-RNO-9013423", "R-BTA-9013408", "R-RNO-5625900", "R-DME-8849932", "R-RNO-422356", "R-HSA-438066", "R-XTR-9013406", "R-BTA-9013404", "R-BTA-422356", "R-BTA-499943", "R-XTR-438066", "R-DME-6794361", "R-MMU-9013026", "R-CFA-438066", "R-SPO-9748787", "R-HSA-5682910", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-399719", "R-HSA-2028269", "R-HSA-9696273", "R-HSA-422356"], "pathways": ["PWY-7221:t:guanosine ribonucleotides de novo biosynthesis", "PWY-8289:t:dZTP biosynthesis", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-2028269:r:Signaling by Hippo", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-420029:r:Tight junction interactions", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-191650:r:Regulation of gap junction activity", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9013424:r:RHOV GTPase cycle", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-447038:r:NrCAM interactions", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-373753:r:Nephrin family interactions", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-MMU-9748787:r:Azathioprine ADME", "R-BTA-5576893:r:Phase 2 - plateau phase", "R-RNO-5682910:r:LGI-ADAM interactions", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-XTR-9013408:r:RHOG GTPase cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-9620244:r:Long-term potentiation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-BTA-9748787:r:Azathioprine ADME", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-5682910:r:LGI-ADAM interactions", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-6794361:r:Neurexins and neuroligins", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-DME-5625900:r:RHO GTPases activate CIT", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-DDI-9748787:r:Azathioprine ADME", "R-MMU-422356:r:Regulation of insulin secretion", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-191650:r:Regulation of gap junction activity", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-MMU-191650:r:Regulation of gap junction activity", "R-BTA-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-9748787:r:Azathioprine ADME", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-6794361:r:Neurexins and neuroligins", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-2028269:r:Signaling by Hippo", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-1236394:r:Signaling by ERBB4", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-RNO-422356:r:Regulation of insulin secretion", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-BTA-422356:r:Regulation of insulin secretion", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-6794361:r:Neurexins and neuroligins", "R-MMU-9013026:r:RHOB GTPase cycle", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-SPO-9748787:r:Azathioprine ADME", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR008146": {"description": "Glutamine synthetase, catalytic domain", "go_ids": ["GO:0004356"], "go_terms": ["GO:0004356:glutamine synthetase activity:F"], "name": "Gln_synth_cat_dom", "pathway_ids": ["PWY-6964", "PWY-8294", "PWY-8291", "PWY-6963", "R-SCE-210455", "R-BTA-8964539", "R-BTA-210455", "R-HSA-8964539", "R-DME-8964539", "R-RNO-8964539", "R-SPO-8964539", "R-CEL-210455", "R-MMU-8964539", "R-MMU-210455", "R-HSA-210455", "R-CEL-8964539", "R-SCE-8964539", "R-DME-210455", "R-SPO-210455", "R-RNO-210455"], "pathways": ["PWY-6964:t:ammonia assimilation cycle II", "PWY-8294:t:L-aspartate degradation III (anaerobic)", "PWY-8291:t:L-aspartate degradation II (aerobic)", "PWY-6963:t:ammonia assimilation cycle I", "R-SCE-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-BTA-8964539:r:Glutamate and glutamine metabolism", "R-BTA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-DME-8964539:r:Glutamate and glutamine metabolism", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-SPO-8964539:r:Glutamate and glutamine metabolism", "R-CEL-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-MMU-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-DME-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-SPO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-RNO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "type": "Domain"}, "IPR008147": {"description": "Glutamine synthetase, N-terminal domain", "go_ids": ["GO:0004356", "GO:1901704"], "go_terms": ["GO:0004356:glutamine synthetase activity:F", "GO:1901704:L-glutamine biosynthetic process:P"], "name": "Gln_synt_N", "pathway_ids": ["PWY-6964", "PWY-8294", "PWY-8291", "PWY-6963", "R-SCE-210455", "R-BTA-8964539", "R-BTA-210455", "R-HSA-8964539", "R-DME-8964539", "R-RNO-8964539", "R-SPO-8964539", "R-CEL-210455", "R-MMU-8964539", "R-MMU-210455", "R-HSA-210455", "R-CEL-8964539", "R-SCE-8964539", "R-DME-210455", "R-SPO-210455", "R-RNO-210455"], "pathways": ["PWY-6964:t:ammonia assimilation cycle II", "PWY-8294:t:L-aspartate degradation III (anaerobic)", "PWY-8291:t:L-aspartate degradation II (aerobic)", "PWY-6963:t:ammonia assimilation cycle I", "R-SCE-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-BTA-8964539:r:Glutamate and glutamine metabolism", "R-BTA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-DME-8964539:r:Glutamate and glutamine metabolism", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-SPO-8964539:r:Glutamate and glutamine metabolism", "R-CEL-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-MMU-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-DME-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-SPO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-RNO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "type": "Domain"}, "IPR008148": {"description": "DNA photolyase class 2", "go_ids": ["GO:0003904", "GO:0006281"], "go_terms": ["GO:0003904:deoxyribodipyrimidine photo-lyase activity:F", "GO:0006281:DNA repair:P"], "name": "DNA_photolyase_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008152": {"description": "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain", "go_ids": ["GO:0006886", "GO:0016192"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P"], "name": "Clathrin_a/b/g-adaptin_app_Ig", "pathway_ids": ["R-HSA-6798695", "R-RNO-5140745", "R-MMU-8856828", "R-SPO-437239", "R-SCE-8856828", "R-HSA-8856828", "R-MMU-5099900", "R-HSA-9918485", "R-BTA-6798695", "R-RNO-8964038", "R-DDI-8856825", "R-DME-5099900", "R-SPO-8856825", "R-RNO-177504", "R-DDI-8856828", "R-DME-3928665", "R-HSA-5140745", "R-DME-8964038", "R-DME-177504", "R-DDI-8964038", "R-RNO-8866427", "R-RNO-432722", "R-DDI-6798695", "R-DME-437239", "R-RNO-432720", "R-BTA-5099900", "R-HSA-432720", "R-DME-5140745", "R-HSA-437239", "R-MMU-5140745", "R-BTA-177504", "R-HSA-164940", "R-RNO-8875656", "R-MMU-8866427", "R-SPO-8866427", "R-SCE-8856825", "R-MMU-6798695", "R-SCE-8866427", "R-RNO-6798695", "R-SPO-6798695", "R-HSA-2132295", "R-DME-416993", "R-HSA-8854214", "R-MMU-8856825", "R-HSA-977225", "R-MMU-432722", "R-SCE-6798695", "R-BTA-416993", "R-DME-8866427", "R-DDI-437239", "R-SPO-8964038", "R-SCE-432720", "R-DDI-8866427", "R-MMU-2132295", "R-MMU-8964038", "R-DME-8856828", "R-BTA-437239", "R-RNO-8856828", "R-BTA-8866427", "R-MMU-432720", "R-RNO-5099900", "R-HSA-432722", "R-SCE-8964038", 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"R-HSA-72187:r:mRNA 3'-end processing", "R-SSC-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-2214320:r:Anchoring fibril formation", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-3000178:r:ECM proteoglycans", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-RNO-3000178:r:ECM proteoglycans", "R-CEL-3000157:r:Laminin interactions", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DRE-3000480:r:Scavenging by Class A Receptors", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-SSC-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-8948216:r:Collagen chain trimerization", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-BTA-173623:r:Classical antibody-mediated complement activation", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-CEL-419037:r:NCAM1 interactions", "R-MMU-419037:r:NCAM1 interactions", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-DME-419037:r:NCAM1 interactions", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-BTA-1442490:r:Collagen degradation", "R-CEL-1566977:r:Fibronectin matrix formation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-RNO-166662:r:Lectin pathway of complement activation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-977606:r:Regulation of Complement cascade", "R-DRE-2129379:r:Molecules associated with elastic fibres", "R-BTA-3000171:r:Non-integrin membrane-ECM interactions", "R-BTA-186797:r:Signaling by PDGF", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-2214320:r:Anchoring fibril formation", "R-BTA-1566977:r:Fibronectin matrix formation", "R-HSA-216083:r:Integrin cell surface interactions", "R-DRE-5173105:r:O-linked glycosylation", "R-HSA-1566977:r:Fibronectin matrix formation", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-5683826:r:Surfactant metabolism", "R-RNO-1442490:r:Collagen degradation", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-8948216:r:Collagen chain trimerization", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-1442490:r:Collagen degradation", "R-MMU-5173105:r:O-linked glycosylation", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Repeat"}, "IPR008162": {"description": "Inorganic pyrophosphatase", "go_ids": ["GO:0000287", "GO:0004427", "GO:0005737", "GO:0006796"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0004427:inorganic diphosphate phosphatase activity:F", "GO:0005737:cytoplasm:C", "GO:0006796:phosphate-containing compound metabolic process:P"], "name": "Pyrophosphatase", "pathway_ids": ["PWY-7807", "PWY-7805", "R-DME-379716", "R-HSA-379726", "R-SPO-379716", "R-PFA-379726", "R-PFA-379716", "R-CEL-379726", "R-HSA-71737", "R-SCE-71737", "R-DDI-71737", "R-MMU-379726", "R-HSA-379716", "R-SPO-379726", "R-CEL-71737", "R-PFA-71737", "R-DDI-379716", "R-DME-379726", "R-MMU-71737", "R-DDI-379726", "R-SCE-379726", "R-BTA-379716", "R-DME-71737", "R-BTA-71737", "R-MMU-379716", "R-CEL-379716", "R-SCE-379716", "R-SPO-71737"], "pathways": ["PWY-7807:t:glyphosate degradation III", "PWY-7805:t:(aminomethyl)phosphonate degradation", "R-DME-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-SPO-379716:r:Cytosolic tRNA aminoacylation", "R-PFA-379726:r:Mitochondrial tRNA aminoacylation", "R-PFA-379716:r:Cytosolic tRNA aminoacylation", "R-CEL-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-71737:r:Pyrophosphate hydrolysis", "R-SCE-71737:r:Pyrophosphate hydrolysis", "R-DDI-71737:r:Pyrophosphate hydrolysis", "R-MMU-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-SPO-379726:r:Mitochondrial tRNA aminoacylation", "R-CEL-71737:r:Pyrophosphate hydrolysis", "R-PFA-71737:r:Pyrophosphate hydrolysis", "R-DDI-379716:r:Cytosolic tRNA aminoacylation", "R-DME-379726:r:Mitochondrial tRNA aminoacylation", "R-MMU-71737:r:Pyrophosphate hydrolysis", "R-DDI-379726:r:Mitochondrial tRNA aminoacylation", "R-SCE-379726:r:Mitochondrial tRNA aminoacylation", "R-BTA-379716:r:Cytosolic tRNA aminoacylation", "R-DME-71737:r:Pyrophosphate hydrolysis", "R-BTA-71737:r:Pyrophosphate hydrolysis", "R-MMU-379716:r:Cytosolic tRNA aminoacylation", "R-CEL-379716:r:Cytosolic tRNA aminoacylation", "R-SCE-379716:r:Cytosolic tRNA aminoacylation", "R-SPO-71737:r:Pyrophosphate hydrolysis"], "type": "Family"}, "IPR008164": {"description": "Repeat of unknown function XGLTT", "go_ids": [], "go_terms": [], "name": "XGLTT_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR008166": {"description": "Glycosyltransferase family 92", "go_ids": [], "go_terms": [], "name": "Glyco_transf_92", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR008173": {"description": "Adenylyl cyclase CyaB", "go_ids": [], "go_terms": [], "name": "Adenylyl_cyclase_CyaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008174": {"description": "Galanin", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Galanin", "pathway_ids": ["R-DRE-418594", "R-DRE-375276", "R-BTA-418594", "R-HSA-418594", "R-RNO-375276", "R-HSA-375276", "R-MMU-375276", "R-MMU-418594", "R-BTA-375276", "R-RNO-418594"], "pathways": ["R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-375276:r:Peptide ligand-binding receptors", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Domain"}, "IPR008175": {"description": "Galanin precursor", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Galanin_pre", "pathway_ids": ["R-DRE-418594", "R-DRE-375276", "R-BTA-418594", "R-HSA-418594", "R-RNO-375276", "R-HSA-375276", "R-MMU-375276", "R-MMU-418594", "R-BTA-375276", "R-RNO-418594"], "pathways": ["R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-375276:r:Peptide ligand-binding receptors", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR008179": {"description": "Phosphoribosyl-ATP pyrophosphohydrolase", "go_ids": ["GO:0000105", "GO:0004636"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0004636:phosphoribosyl-ATP diphosphatase activity:F"], "name": "HisE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008181": {"description": "Deoxyuridine triphosphate nucleotidohydrolase", "go_ids": ["GO:0046081", "GO:0000287", "GO:0006226", "GO:0004170"], "go_terms": ["GO:0046081:dUTP catabolic process:P", "GO:0000287:magnesium ion binding:F", "GO:0006226:dUMP biosynthetic process:P", "GO:0004170:dUTP diphosphatase activity:F"], "name": "dUTPase", "pathway_ids": ["R-SCE-499943", "R-SPO-499943", "R-HSA-499943", "R-DDI-499943", "R-RNO-499943", "R-MMU-499943"], "pathways": ["R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR008183": {"description": "Aldose 1-/Glucose-6-phosphate 1-epimerase", "go_ids": ["GO:0005975", "GO:0016853"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016853:isomerase activity:F"], "name": "Aldose_1/G6P_1-epimerase", "pathway_ids": ["R-HSA-70370", "R-MMU-70370", "R-HSA-9931929", "R-SPO-70370", "R-RNO-70370", "R-SCE-70370", "R-BTA-70370", "R-SSC-70370"], "pathways": ["R-HSA-70370:r:Galactose catabolism", "R-MMU-70370:r:Galactose catabolism", "R-HSA-9931929:r:Defective GALM causes GALAC4", "R-SPO-70370:r:Galactose catabolism", "R-RNO-70370:r:Galactose catabolism", "R-SCE-70370:r:Galactose catabolism", "R-BTA-70370:r:Galactose catabolism", "R-SSC-70370:r:Galactose catabolism"], "type": "Family"}, "IPR008187": {"description": "Vpu protein", "go_ids": ["GO:0032801", "GO:0033644", "GO:0005261", "GO:0019076"], "go_terms": ["GO:0032801:receptor catabolic process:P", "GO:0033644:host cell membrane:C", "GO:0005261:monoatomic cation channel activity:F", "GO:0019076:viral release from host cell:P"], "name": "Vpu", "pathway_ids": ["R-HSA-180910", "R-HSA-162592", "R-HSA-171286", "R-HSA-177539", "R-HSA-180534", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-164525", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-173107", "R-HSA-162594"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-171286:r:Synthesis and processing of ENV and VPU", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Family"}, "IPR008189": {"description": "rRNA small subunit methyltransferase I", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "rRNA_ssu_MeTfrase_I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008195": {"description": "Large ribosomal subunit protein eL34", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL34", "pathway_ids": ["R-HSA-9954716", "R-MMU-72689", "R-HSA-9010553", "R-HSA-156827", "R-DRE-9954709", "R-MMU-9954709", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-SSC-156827", "R-HSA-9954709", "R-SSC-72706", "R-MMU-975956", "R-HSA-1799339", "R-DRE-156827", "R-HSA-2408557", "R-DRE-975956", "R-MMU-6791226", "R-DRE-9954714", "R-MMU-9954714", "R-SSC-975956", "R-SSC-9954714", "R-MMU-975957", "R-HSA-156902", "R-HSA-72706", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SSC-9954709", "R-MMU-156827", "R-SSC-1799339", "R-DRE-1799339", "R-MMU-1799339", "R-HSA-975957", "R-SSC-975957", "R-HSA-6791226", "R-DRE-72689", "R-DRE-9954716", "R-SSC-72689", "R-SSC-6791226", "R-DRE-6791226", "R-HSA-9954714", "R-SSC-9954716", "R-HSA-9633012"], "pathways": ["R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-2408557:r:Selenocysteine synthesis", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR008197": {"description": "WAP-type 'four-disulfide core' domain", "go_ids": ["GO:0005576", "GO:0030414"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0030414:peptidase inhibitor activity:F"], "name": "WAP_dom", "pathway_ids": ["R-HSA-6798695", "R-RNO-6803157", "R-HSA-6809371", "R-SSC-6803157", "R-SSC-6809371", "R-HSA-6803157", "R-HSA-5654726", "R-HSA-9830364", "R-GGA-190373", "R-MMU-6798695", "R-HSA-190373", "R-MMU-6803157", "R-GGA-5654726", "R-HSA-9927418", "R-HSA-9927426"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-HSA-6809371:r:Formation of the cornified envelope", "R-SSC-6803157:r:Antimicrobial peptides", "R-SSC-6809371:r:Formation of the cornified envelope", "R-HSA-6803157:r:Antimicrobial peptides", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-GGA-190373:r:FGFR1c ligand binding and activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-6803157:r:Antimicrobial peptides", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Domain"}, "IPR008200": {"description": "Neuromedin U, C-terminal", "go_ids": ["GO:0006940"], "go_terms": ["GO:0006940:regulation of smooth muscle contraction:P"], "name": "NMU_C", "pathway_ids": ["R-MMU-416476", "R-SSC-375276", "R-HSA-418594", "R-RNO-375276", "R-GGA-418594", "R-HSA-375276", "R-MMU-418594", "R-GGA-416476", "R-SSC-416476", "R-SSC-418594", "R-MMU-375276", "R-HSA-416476", "R-RNO-416476", "R-GGA-375276", "R-RNO-418594"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-GGA-418594:r:G alpha (i) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-GGA-416476:r:G alpha (q) signalling events", "R-SSC-416476:r:G alpha (q) signalling events", "R-SSC-418594:r:G alpha (i) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-GGA-375276:r:Peptide ligand-binding receptors", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Domain"}, "IPR008201": {"description": "Ribonuclease HepT-like", "go_ids": ["GO:0004540", "GO:0110001"], "go_terms": ["GO:0004540:RNA nuclease activity:F", "GO:0110001:toxin-antitoxin complex:C"], "name": "HepT-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008203": {"description": "AF2212-like", "go_ids": [], "go_terms": [], "name": "AF2212-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008205": {"description": "Geranylgeranylglyceryl phosphate synthase/Heptaprenylglyceryl phosphate synthase", "go_ids": ["GO:0016765"], "go_terms": ["GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "GGGP_HepGP_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008207": {"description": "Signal transduction histidine kinase, phosphotransfer (Hpt) domain", "go_ids": ["GO:0000160"], "go_terms": ["GO:0000160:phosphorelay signal transduction system:P"], "name": "Sig_transdc_His_kin_Hpt_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008209": {"description": "Phosphoenolpyruvate carboxykinase, GTP-utilising", "go_ids": ["GO:0004611", "GO:0005525", "GO:0006094"], "go_terms": ["GO:0004611:phosphoenolpyruvate carboxykinase activity:F", "GO:0005525:GTP binding:F", "GO:0006094:gluconeogenesis:P"], "name": "PEP_carboxykinase_GTP", "pathway_ids": ["PWY-7383", "R-HSA-70263", "R-HSA-9615017", "R-HSA-381340", "R-HSA-9632974", "R-MMU-70263", "R-HSA-2161541", "R-GGA-352875", "R-DME-70263", "R-DDI-70263", "R-RNO-70263"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "R-HSA-70263:r:Gluconeogenesis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-HSA-2161541:r:Abacavir metabolism", "R-GGA-352875:r:Gluconeogenesis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Family"}, "IPR008210": {"description": "Phosphoenolpyruvate carboxykinase, N-terminal", "go_ids": ["GO:0004611", "GO:0006094", "GO:0017076"], "go_terms": ["GO:0004611:phosphoenolpyruvate carboxykinase activity:F", "GO:0006094:gluconeogenesis:P", "GO:0017076:purine nucleotide binding:F"], "name": "PEP_carboxykinase_N", "pathway_ids": ["PWY-561", "PWY-7117", "R-HSA-70263", "R-HSA-9615017", "R-HSA-381340", "R-HSA-9632974", "R-MMU-70263", "R-HSA-2161541", "R-GGA-352875", "R-DME-70263", "R-DDI-70263", "R-RNO-70263"], "pathways": ["PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "R-HSA-70263:r:Gluconeogenesis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-HSA-2161541:r:Abacavir metabolism", "R-GGA-352875:r:Gluconeogenesis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR008211": {"description": "Laminin, N-terminal", "go_ids": [], "go_terms": [], "name": "Laminin_N", "pathway_ids": ["R-HSA-1474228", "R-HSA-9925563", "R-HSA-2214320", "R-HSA-8874081", "R-HSA-3000157", "R-HSA-3000178", "R-HSA-428542", "R-HSA-418886", "R-HSA-9913351", "R-HSA-9619665", "R-HSA-3000171", "R-HSA-418885", "R-HSA-373752", "R-HSA-6785807", "R-HSA-373760", "R-HSA-163125", "R-HSA-9638630", "R-HSA-2022090", "R-MMU-373752", "R-HSA-418890", "R-HSA-8957275", "R-HSA-376172", "R-HSA-446107", "R-HSA-525793", "R-HSA-381426", "R-DME-373752"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-3000157:r:Laminin interactions", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-373760:r:L1CAM interactions", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-376172:r:DSCAM interactions", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-525793:r:Myogenesis", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-373752:r:Netrin-1 signaling"], "type": "Domain"}, "IPR008213": {"description": "CpcD-like domain", "go_ids": ["GO:0030089"], "go_terms": ["GO:0030089:phycobilisome:C"], "name": "CpcD-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008215": {"description": "Tachykinin domain", "go_ids": ["GO:0007217"], "go_terms": ["GO:0007217:tachykinin receptor signaling pathway:P"], "name": "Tachykinin_dom", "pathway_ids": ["R-MMU-416476", "R-HSA-380095", "R-BTA-380095", "R-MMU-380095", "R-HSA-416476", "R-RNO-416476", "R-RNO-380095", "R-BTA-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-380095:r:Tachykinin receptors bind tachykinins", "R-BTA-380095:r:Tachykinin receptors bind tachykinins", "R-MMU-380095:r:Tachykinin receptors bind tachykinins", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-380095:r:Tachykinin receptors bind tachykinins", "R-BTA-416476:r:G alpha (q) signalling events"], "type": "Domain"}, "IPR008217": {"description": "Ccc1 family", "go_ids": ["GO:0005384", "GO:0030026"], "go_terms": ["GO:0005384:manganese ion transmembrane transporter activity:F", "GO:0030026:intracellular manganese ion homeostasis:P"], "name": "Ccc1_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008218": {"description": "ATPase, V1 complex, subunit F", "go_ids": ["GO:0046961", "GO:0034220"], "go_terms": ["GO:0046961:proton-transporting ATPase activity, rotational mechanism:F", "GO:0034220:monoatomic ion transmembrane transport:P"], "name": "ATPase_V1-cplx_f_g_su", "pathway_ids": ["R-CEL-1222556", "R-MMU-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-MMU-9639288", "R-SPO-9639288", "R-RNO-1222556", "R-HSA-9639288", "R-RNO-983712", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-RNO-917977", "R-SCE-917977", "R-SCE-1222556", "R-DDI-9639288", "R-BTA-1222556", "R-MMU-77387", "R-SCE-77387", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-RNO-77387", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-RNO-9639288", "R-HSA-917977", "R-DDI-917977", "R-DDI-983712", "R-MMU-983712", "R-BTA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-RNO-983712:r:Ion channel transport", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-77387:r:Insulin receptor recycling", "R-SCE-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-RNO-77387:r:Insulin receptor recycling", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-DDI-983712:r:Ion channel transport", "R-MMU-983712:r:Ion channel transport", "R-BTA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR008219": {"description": "Proline dehydrogenase, bacteria and archaea", "go_ids": ["GO:0006562", "GO:0004657"], "go_terms": ["GO:0006562:L-proline catabolic process:P", "GO:0004657:proline dehydrogenase activity:F"], "name": "PRODH_bac_arc", "pathway_ids": ["PWY-6922", "PWY-5737"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-5737:t:(5R)-carbapenem carboxylate biosynthesis"], "type": "Family"}, "IPR008220": {"description": "Homoserine/serine acetyltransferase MetX-like", "go_ids": ["GO:0016747", "GO:0009058"], "go_terms": ["GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F", "GO:0009058:biosynthetic process:P"], "name": "HAT_MetX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008221": {"description": "Urease", "go_ids": ["GO:0009039", "GO:0016151"], "go_terms": ["GO:0009039:urease activity:F", "GO:0016151:nickel cation binding:F"], "name": "Urease", "pathway_ids": ["PWY-5704"], "pathways": ["PWY-5704:t:urea degradation II"], "type": "Family"}, "IPR008223": {"description": "Urease, gamma-beta subunit", "go_ids": ["GO:0043419"], "go_terms": ["GO:0043419:urea catabolic process:P"], "name": "Urease_gamma-beta_su", "pathway_ids": ["PWY-5704"], "pathways": ["PWY-5704:t:urea degradation II"], "type": "Family"}, "IPR008225": {"description": "Coenzyme F420:L-glutamate ligase", "go_ids": ["GO:0043773", "GO:0046872"], "go_terms": ["GO:0043773:coenzyme F420-0 gamma-glutamyl ligase activity:F", "GO:0046872:metal ion binding:F"], "name": "F420-0_g-glutamyl_ligase", "pathway_ids": ["PWY-5199"], "pathways": ["PWY-5199:t:factor 420 polyglutamylation"], "type": "Family"}, "IPR008226": {"description": "Mini-ribonuclease 3 family", "go_ids": [], "go_terms": [], "name": "Mini3_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008228": {"description": "Uncharacterised conserved protein UCP006173", "go_ids": [], "go_terms": [], "name": "UCP006173", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008229": {"description": "tRNA nucleotidyltransferase, archaea", "go_ids": ["GO:0001680", "GO:0003723", "GO:0004810"], "go_terms": ["GO:0001680:tRNA 3'-terminal CCA addition:P", "GO:0003723:RNA binding:F", "GO:0004810:CCA tRNA nucleotidyltransferase activity:F"], "name": "CCA-adding_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008231": {"description": "Probable chaperone CsaA", "go_ids": [], "go_terms": [], "name": "CsaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008238": {"description": "Chorismate mutase, AroQ class, eukaryotic type", "go_ids": ["GO:0004106", "GO:0009073"], "go_terms": ["GO:0004106:chorismate mutase activity:F", "GO:0009073:aromatic amino acid biosynthetic process:P"], "name": "Chorismate_mutase_AroQ_euk", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis"], "type": "Family"}, "IPR008240": {"description": "Chorismate mutase, periplasmic", "go_ids": [], "go_terms": [], "name": "Chorismate_mutase_periplasmic", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A 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"Family"}, "IPR008244": {"description": "Bifunctional chorismate mutase/prephenate dehydrogenase T-protein", "go_ids": ["GO:0004106", "GO:0005737", "GO:0006571", "GO:0008977"], "go_terms": ["GO:0004106:chorismate mutase activity:F", "GO:0005737:cytoplasm:C", "GO:0006571:L-tyrosine biosynthetic process:P", "GO:0008977:prephenate dehydrogenase (NAD+) activity:F"], "name": "Chor_mut/prephenate_DH_T", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627", "PWY-7303"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7303:t:4-hydroxy-3-prenylbenzoate biosynthesis"], "type": "Family"}, "IPR008248": {"description": "Protein-glutamate methylesterase/protein-glutamine glutaminase, CheB type", "go_ids": ["GO:0000156", "GO:0000160", "GO:0005737", "GO:0006935", "GO:0008984"], "go_terms": ["GO:0000156:phosphorelay response regulator activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0005737:cytoplasm:C", "GO:0006935:chemotaxis:P", "GO:0008984:protein-glutamate methylesterase activity:F"], "name": "CheB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008249": {"description": "Uncharacterised protein family UPF0231", "go_ids": [], "go_terms": [], "name": "UPF0231", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008250": {"description": "P-type ATPase, A domain superfamily", "go_ids": [], "go_terms": [], "name": "ATPase_P-typ_transduc_dom_A_sf", "pathway_ids": ["R-HSA-6798695", "R-GGA-936837", "R-SPO-6798695", "R-RNO-6803544", "R-HSA-6803544", "R-DRE-936837", "R-XTR-936837", "R-CEL-6798695", "R-SCE-6798695", "R-DME-418359", "R-DDI-5578775", "R-BTA-936837", "R-SSC-936837", "R-CFA-936837", "R-MMU-418359", "R-HSA-9662360", "R-BTA-5578775", "R-CFA-5578775", "R-HSA-5578775", "R-MMU-6803544", "R-MMU-936837", "R-CFA-418359", 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megakaryocyte development and platelet production", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins"], "type": "Domain"}, "IPR008253": {"description": "Marvel domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Marvel", "pathway_ids": ["R-HSA-6798695", "R-HSA-8935964", "R-HSA-9662360", "R-DME-6798695", "R-CEL-6798695", "R-MMU-6798695", "R-RNO-351906", "R-MMU-351906", "R-HSA-351906", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR008254": {"description": "Flavodoxin/nitric oxide synthase", "go_ids": ["GO:0010181"], "go_terms": ["GO:0010181:FMN binding:F"], "name": "Flavodoxin/NO_synth", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-MMU-1222556", "R-SSC-9033241", "R-DME-1222556", "R-RNO-9009391", "R-DDI-5578775", "R-MMU-9009391", "R-HSA-1614635", "R-RNO-5218920", "R-HSA-203615", "R-RNO-9033241", "R-HSA-5218920", "R-SPO-9009391", "R-DDI-5218920", "R-RNO-1474151", "R-SCE-9033241", "R-MMU-392154", "R-SPO-1222556", "R-RNO-156581", "R-MMU-1614635", "R-HSA-3359467", "R-DDI-9033241", "R-HSA-203641", "R-SCE-9856530", "R-RNO-203754", "R-SCE-1222556", "R-HSA-9636249", "R-SPO-392154", "R-MMU-5578775", "R-SPO-5218920", "R-SCE-1474151", "R-HSA-6785807", "R-SSC-392154", "R-MMU-156581", "R-HSA-211897", "R-SCE-5578775", "R-DDI-203615", "R-DME-5218920", "R-RNO-203615", "R-HSA-203754", "R-DDI-9856530", "R-MMU-203754", "R-DME-203754", "R-SCE-203615", "R-HSA-6782861", "R-DME-1474151", "R-HSA-9759218", "R-DDI-392154", "R-DME-9856530", "R-MMU-9856530", "R-HSA-1474151", "R-HSA-392154", "R-DDI-9009391", "R-SPO-1474151", "R-RNO-9759218", "R-MMU-203615", "R-RNO-1222556", "R-MMU-203641", "R-SCE-392154", "R-RNO-392154", "R-HSA-1222556", "R-DME-9009391", "R-MMU-9759218", "R-HSA-5578775", "R-DDI-1222556", "R-RNO-203641", "R-SPO-5578775", "R-SPO-9856530", "R-SSC-1222556", "R-HSA-2564830", "R-DDI-1474151", "R-MMU-5218920", "R-CEL-9759218", "R-DME-392154", "R-RNO-5578775", "R-DME-5578775", "R-DME-9033241", "R-SCE-9009391", "R-MMU-9033241", "R-DME-203615", "R-MMU-1474151", "R-HSA-3359469", "R-SPO-203615", "R-CEL-1614635", "R-RNO-9856530", "R-HSA-9009391", "R-SPO-9033241", "R-DDI-203754", "R-HSA-156581", "R-HSA-9856530", "R-HSA-9033241", "R-SCE-5218920"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-9033241:r:Peroxisomal protein import", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-5578775:r:Ion homeostasis", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-203615:r:eNOS activation", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SCE-9033241:r:Peroxisomal protein import", "R-MMU-392154:r:Nitric oxide stimulates guanylate cyclase", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-156581:r:Methylation", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-203754:r:NOSIP mediated eNOS trafficking", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-SPO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-5578775:r:Ion homeostasis", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-156581:r:Methylation", "R-HSA-211897:r:Cytochrome P450 - arranged by substrate type", "R-SCE-5578775:r:Ion homeostasis", "R-DDI-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-203615:r:eNOS activation", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-DME-203754:r:NOSIP mediated eNOS trafficking", "R-SCE-203615:r:eNOS activation", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-DDI-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-203615:r:eNOS activation", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-SCE-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-5578775:r:Ion homeostasis", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-SPO-5578775:r:Ion homeostasis", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-DME-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-5578775:r:Ion homeostasis", "R-DME-5578775:r:Ion homeostasis", "R-DME-9033241:r:Peroxisomal protein import", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9033241:r:Peroxisomal protein import", "R-DME-203615:r:eNOS activation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-SPO-203615:r:eNOS activation", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-9033241:r:Peroxisomal protein import", "R-DDI-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-156581:r:Methylation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9033241:r:Peroxisomal protein import", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Domain"}, "IPR008256": {"description": "Peptidase S1B", "go_ids": ["GO:0006508", "GO:0008236"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008236:serine-type peptidase activity:F"], "name": "Peptidase_S1B", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR008257": {"description": "Peptidase M19", "go_ids": ["GO:0070573", "GO:0006508"], "go_terms": ["GO:0070573:metallodipeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_M19", "pathway_ids": ["PWY-8355", "PWY-8397", "PWY-7533", "R-MMU-5423646", "R-SSC-2142691", "R-HSA-2142691", "R-SPO-2142691", "R-BTA-5423646", "R-RNO-2142691", "R-SPO-5423646", "R-RNO-5423646", "R-MMU-2142691", "R-BTA-2142691", "R-HSA-5423646", "R-HSA-9664535", "R-SSC-5423646"], "pathways": ["PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-SSC-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-BTA-5423646:r:Aflatoxin activation and detoxification", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-5423646:r:Aflatoxin activation and detoxification", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-HSA-9664535:r:LTC4-CYSLTR mediated IL4 production", "R-SSC-5423646:r:Aflatoxin activation and detoxification"], "type": "Family"}, "IPR008258": {"description": "Transglycosylase SLT domain 1", "go_ids": [], "go_terms": [], "name": "Transglycosylase_SLT_dom_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008264": {"description": "Beta-glucanase", "go_ids": ["GO:0004553", "GO:0005975"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Beta_glucanase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008269": {"description": "Peptidase S16, Lon proteolytic domain", "go_ids": ["GO:0004176", "GO:0004252", "GO:0006508"], "go_terms": ["GO:0004176:ATP-dependent peptidase activity:F", "GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Lon_proteolytic", "pathway_ids": ["R-BTA-9033241", "R-DDI-9837999", "R-RNO-9033241", "R-MMU-9837999", "R-CEL-9837999", "R-HSA-390471", "R-SPO-9837999", "R-SCE-9837999", "R-DME-9837999", "R-HSA-9841251", "R-HSA-9837999", "R-MMU-9033241", "R-RNO-9837999", "R-HSA-9033241"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR008274": {"description": "Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "AldOxase/xan_DH_MoCoBD1", "pathway_ids": ["R-MMU-9748787", "R-RNO-8851680", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", "R-RNO-74259", "R-GGA-421178", "R-DME-964975", "R-MMU-8851680", "R-HSA-9748787", "R-HSA-74259", "R-RNO-964975", "R-DME-74259", "R-MMU-964975", "R-CEL-964975", "R-DME-9748787", "R-MMU-74259", "R-DDI-964975", "R-RNO-9748787", "R-DDI-74259"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-GGA-421178:r:Urate synthesis", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-74259:r:Purine catabolism", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Domain"}, "IPR008275": {"description": "Acyl-CoA dehydratase activase domain", "go_ids": [], "go_terms": [], "name": "CoA_E_activase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008276": {"description": "Concentrative nucleoside transporter", "go_ids": ["GO:0005337", "GO:1901642", "GO:0016020"], "go_terms": ["GO:0005337:nucleoside transmembrane transporter activity:F", "GO:1901642:nucleoside transmembrane transport:P", "GO:0016020:membrane:C"], "name": "C_nuclsd_transpt", "pathway_ids": ["R-MMU-9748787", "R-MMU-9755088", "R-RNO-83936", "R-HSA-9748787", "R-HSA-83936", "R-RNO-9748787", "R-RNO-9755088", "R-HSA-9755088", "R-MMU-83936"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-MMU-9755088:r:Ribavirin ADME", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-9748787:r:Azathioprine ADME", "R-RNO-9755088:r:Ribavirin ADME", "R-HSA-9755088:r:Ribavirin ADME", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "type": "Family"}, "IPR008278": {"description": "4'-phosphopantetheinyl transferase domain", "go_ids": ["GO:0000287", "GO:0008897"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0008897:holo-[acyl-carrier-protein] synthase activity:F"], "name": "4-PPantetheinyl_Trfase_dom", "pathway_ids": ["PWY-6012", "PWY-6289", "R-MMU-199220", "R-RNO-199220", "R-HSA-199220"], "pathways": ["PWY-6012:t:acyl carrier protein metabolism", "PWY-6289:t:petrobactin biosynthesis", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Domain"}, "IPR008279": {"description": "PEP-utilising enzyme, mobile domain", "go_ids": ["GO:0016310", "GO:0016772"], "go_terms": ["GO:0016310:phosphorylation:P", "GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "PEP-util_enz_mobile_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008280": {"description": "Tubulin/FtsZ, C-terminal", "go_ids": [], "go_terms": [], "name": "Tub_FtsZ_C", "pathway_ids": ["R-RNO-190840", "R-HSA-9646399", "R-SSC-3371497", "R-HSA-9833482", "R-XTR-190840", "R-MMU-9668328", "R-RNO-5610787", "R-MMU-68877", "R-DDI-114608", "R-HSA-9668328", "R-MMU-380320", "R-SSC-5620924", "R-SSC-9833482", "R-HSA-6811434", "R-SSC-2132295", "R-XTR-6811434", "R-BTA-2565942", "R-MMU-5610787", "R-RNO-380284", "R-BTA-2500257", "R-SSC-2565942", "R-MMU-5620912", "R-MMU-6811434", "R-DDI-6798695", "R-SSC-8854518", "R-HSA-5620924", "R-MMU-9013407", "R-MMU-380259", "R-XTR-6807878", "R-RNO-9013407", "R-HSA-437239", "R-CEL-6807878", "R-MMU-380270", "R-SSC-5620920", "R-HSA-9609690", "R-CEL-5620924", "R-RNO-5663220", "R-XTR-380320", "R-RNO-6811436", "R-MMU-9646399", "R-BTA-6811436", "R-HSA-8955332", "R-SSC-6807878", "R-HSA-1445148", "R-HSA-389960", "R-RNO-5620924", "R-HSA-389957", "R-BTA-9648025", "R-HSA-9609736", "R-RNO-380270", "R-MMU-5663220", "R-MMU-3371497", "R-RNO-6798695", "R-GGA-6807878", "R-GGA-9646399", "R-DDI-9668328", "R-SSC-6798695", "R-HSA-2467813", "R-MMU-8852276", "R-SCE-6798695", "R-MMU-983189", "R-RNO-3371497", "R-MMU-5620920", "R-HSA-3371497", "R-SSC-5626467", "R-MMU-380284", "R-HSA-114608", "R-BTA-6807878", "R-SSC-5610787", "R-RNO-2565942", "R-HSA-68877", "R-MMU-8955332", "R-MMU-2132295", "R-BTA-380320", "R-XTR-9668328", "R-BTA-2132295", "R-HSA-6811436", "R-SSC-9668328", "R-SSC-9648025", "R-DDI-9833482", "R-GGA-3371497", "R-MMU-437239", "R-DDI-5610787", "R-RNO-2132295", "R-MMU-5626467", "R-DME-6811436", "R-RNO-437239", "R-RNO-68877", "R-XTR-9648025", "R-DME-6798695", "R-RNO-5626467", "R-HSA-380270", "R-XTR-8852276", "R-RNO-380259", "R-XTR-9646399", "R-RNO-9646399", "R-HSA-5663220", "R-RNO-9648025", "R-XTR-8854518", "R-RNO-9833482", "R-XTR-8955332", "R-SSC-5620912", "R-HSA-6798695", "R-SSC-5663220", "R-HSA-190861", "R-RNO-983189", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-BTA-6798695", "R-SSC-190840", "R-HSA-8854518", "R-DDI-5626467", "R-MMU-2565942", "R-RNO-380320", "R-BTA-380259", "R-HSA-380320", "R-MMU-9833482", "R-SSC-9013407", "R-XTR-3371497", "R-GGA-9648025", "R-BTA-5620912", "R-HSA-389977", "R-DME-6807878", "R-MMU-5620924", "R-BTA-9013407", "R-SSC-380259", "R-PFA-9646399", "R-XTR-5620920", "R-HSA-9648025", "R-DDI-8955332", "R-XTR-6798695", "R-XTR-380259", "R-MMU-6811436", "R-GGA-5620924", "R-SSC-380284", "R-HSA-5620920", "R-MMU-8854518", "R-MMU-6798695", "R-BTA-3371497", "R-RNO-2467813", "R-BTA-9646399", "R-GGA-983189", "R-BTA-5620924", "R-XTR-114608", "R-SSC-983189", "R-HSA-9013407", "R-MMU-114608", "R-RNO-9668328", "R-SSC-9646399", "R-SSC-6811434", "R-SPO-6798695", "R-HSA-2132295", "R-SSC-380270", "R-HSA-9619483", "R-HSA-190840", "R-HSA-5626467", "R-RNO-2500257", "R-DDI-5620920", "R-XTR-2467813", "R-SSC-68877", "R-XTR-380270", "R-MMU-6807878", "R-RNO-5620912", "R-GGA-2500257", "R-RNO-114608", "R-HSA-2565942", "R-BTA-114608", "R-BTA-2467813", "R-XTR-5620912", "R-HSA-5610787", "R-SSC-8955332", "R-RNO-8852276", "R-GGA-2467813", "R-MMU-9648025", "R-HSA-5620912", "R-BTA-380284", "R-PFA-3371497", "R-MMU-2500257", "R-GGA-6811436", "R-MMU-190840", "R-HSA-2500257", "R-RNO-6811434", "R-RNO-8854518", "R-RNO-6807878", "R-HSA-6807878", "R-HSA-8852276", "R-CEL-6811436", "R-XTR-5663220", "R-RNO-5620920", "R-HSA-9679191", "R-XTR-380284", "R-XTR-68877", "R-SSC-8852276", "R-SSC-2467813", "R-XTR-983189", "R-BTA-8854518", "R-BTA-380270", "R-DDI-6807878", "R-HSA-983189", "R-XTR-5620924", "R-XTR-2565942", "R-PFA-6798695", "R-SSC-380320", "R-PFA-5620920", "R-RNO-8955332", "R-SSC-2500257", "R-HSA-380259", "R-XTR-2500257", "R-PFA-8955332", "R-GGA-6811434"], "pathways": ["R-RNO-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-9646399:r:Aggrephagy", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9833482:r:PKR-mediated signaling", "R-XTR-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-DDI-114608:r:Platelet degranulation", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-5620924:r:Intraflagellar transport", "R-SSC-9833482:r:PKR-mediated signaling", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SSC-2132295:r:MHC class II antigen presentation", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-6807878:r:COPI-mediated anterograde transport", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-437239:r:Recycling pathway of L1", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SSC-5620920:r:Cargo trafficking to the periciliary membrane", "R-HSA-9609690:r:HCMV Early Events", "R-CEL-5620924:r:Intraflagellar transport", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-389960:r:Formation of tubulin folding intermediates by CCT/TriC", "R-RNO-5620924:r:Intraflagellar transport", "R-HSA-389957:r:Prefoldin mediated transfer of substrate to CCT/TriC", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-6798695:r:Neutrophil degranulation", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-GGA-9646399:r:Aggrephagy", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-983189:r:Kinesins", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-5620920:r:Cargo trafficking to the periciliary membrane", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SSC-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-114608:r:Platelet degranulation", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-SSC-5610787:r:Hedgehog 'off' state", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-BTA-2132295:r:MHC class II antigen presentation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-9833482:r:PKR-mediated signaling", "R-GGA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-437239:r:Recycling pathway of L1", "R-DDI-5610787:r:Hedgehog 'off' state", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-437239:r:Recycling pathway of L1", "R-RNO-68877:r:Mitotic Prometaphase", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-9646399:r:Aggrephagy", "R-RNO-9646399:r:Aggrephagy", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-RNO-9833482:r:PKR-mediated signaling", "R-XTR-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-HSA-190861:r:Gap junction assembly", "R-RNO-983189:r:Kinesins", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9833482:r:PKR-mediated signaling", "R-SSC-9013407:r:RHOH GTPase cycle", "R-XTR-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-BTA-9013407:r:RHOH GTPase cycle", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-XTR-5620920:r:Cargo trafficking to the periciliary membrane", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-XTR-6798695:r:Neutrophil degranulation", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-GGA-5620924:r:Intraflagellar transport", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-5620920:r:Cargo trafficking to the periciliary membrane", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-9646399:r:Aggrephagy", "R-GGA-983189:r:Kinesins", "R-BTA-5620924:r:Intraflagellar transport", "R-XTR-114608:r:Platelet degranulation", "R-SSC-983189:r:Kinesins", "R-HSA-9013407:r:RHOH GTPase cycle", "R-MMU-114608:r:Platelet degranulation", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SSC-9646399:r:Aggrephagy", "R-SSC-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-HSA-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-5620920:r:Cargo trafficking to the periciliary membrane", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-SSC-68877:r:Mitotic Prometaphase", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-114608:r:Platelet degranulation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-114608:r:Platelet degranulation", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5610787:r:Hedgehog 'off' state", "R-SSC-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-RNO-5620920:r:Cargo trafficking to the periciliary membrane", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-68877:r:Mitotic Prometaphase", "R-SSC-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-XTR-983189:r:Kinesins", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-983189:r:Kinesins", "R-XTR-5620924:r:Intraflagellar transport", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-PFA-6798695:r:Neutrophil degranulation", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-PFA-5620920:r:Cargo trafficking to the periciliary membrane", "R-RNO-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-PFA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR008283": {"description": "Peptidase M17, leucyl aminopeptidase, N-terminal", "go_ids": ["GO:0006508", "GO:0070006"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0070006:metalloaminopeptidase activity:F"], "name": "Peptidase_M17_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008286": {"description": "Orn/Lys/Arg decarboxylase, C-terminal", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Prn/Lys/Arg_de-COase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008288": {"description": "Poly [ADP-ribose] polymerase", "go_ids": ["GO:0003677", "GO:0003950", "GO:0005634", "GO:0008270", "GO:0051287"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003950:NAD+ poly-ADP-ribosyltransferase activity:F", "GO:0005634:nucleus:C", "GO:0008270:zinc ion binding:F", "GO:0051287:NAD binding:F"], "name": "PARP", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-MMU-2173795", "R-HSA-3108214", "R-HSA-192814", "R-RNO-5696395", "R-HSA-110362", "R-DRE-5696400", "R-RNO-5685939", "R-DME-5696395", "R-RNO-110362", "R-RNO-3108214", "R-DRE-5685939", "R-HSA-5685939", "R-DRE-5696394", "R-DME-5696394", "R-DRE-110362", "R-RNO-5696394", "R-DRE-5696395", "R-DRE-3108214", "R-MMU-5696395", "R-RNO-2173795", "R-MMU-110362", "R-DME-5696400", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-2173795", "R-HSA-5696394", "R-RNO-5696400", "R-MMU-5685939", "R-HSA-5696400", "R-MMU-5696394", "R-MMU-3108214", "R-CEL-5696394", "R-MMU-5696400"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-192814:r:vRNA Synthesis", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696400:r:Dual Incision in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER"], "type": "Family"}, "IPR008289": {"description": "Pentafunctional AroM protein", "go_ids": ["GO:0003855", "GO:0003856", "GO:0003866", "GO:0004764", "GO:0004765", "GO:0009073"], "go_terms": ["GO:0003855:3-dehydroquinate dehydratase activity:F", "GO:0003856:3-dehydroquinate synthase activity:F", "GO:0003866:3-phosphoshikimate 1-carboxyvinyltransferase activity:F", "GO:0004764:shikimate 3-dehydrogenase (NADP+) activity:F", "GO:0004765:shikimate kinase activity:F", "GO:0009073:aromatic amino acid biosynthetic process:P"], "name": "Pentafunct_AroM", "pathway_ids": ["PWY-6164", "PWY-6707", "PWY-6163", "PWY-6416"], "pathways": ["PWY-6164:t:3-dehydroquinate biosynthesis I", "PWY-6707:t:gallate biosynthesis", "PWY-6163:t:chorismate biosynthesis from 3-dehydroquinate", "PWY-6416:t:quinate degradation II"], "type": "Family"}, "IPR008290": {"description": "Phosphatidylinositol 3-kinase, Vps34 type", "go_ids": ["GO:0016303", "GO:0046854"], "go_terms": ["GO:0016303:1-phosphatidylinositol-3-kinase activity:F", "GO:0046854:phosphatidylinositol phosphate biosynthetic process:P"], "name": "PI3K_Vps34", "pathway_ids": ["PWY-6352", "R-SCE-1660516", "R-CEL-1660516", "R-HSA-9679504", "R-HSA-1660517", "R-HSA-9705671", "R-MMU-1660516", "R-CEL-1660514", "R-SCE-1660514", "R-MMU-1632852", "R-CEL-1632852", "R-RNO-109704", "R-CEL-5668599", "R-RNO-1660514", "R-SPO-1660516", "R-RNO-5668599", "R-RNO-168138", "R-RNO-1632852", "R-RNO-1660516", "R-SCE-1660517", "R-SPO-5668599", "R-MMU-5668599", "R-MMU-1660514", "R-HSA-5668599", "R-HSA-9920951", "R-DDI-1660517", "R-DDI-5668599", "R-HSA-9694676", "R-HSA-168138", "R-DDI-1632852", "R-MMU-109704", "R-DDI-1660516", "R-SPO-1660514", "R-HSA-109704", "R-HSA-1660514", "R-HSA-1660516", "R-HSA-983170", "R-SCE-1632852", "R-RNO-1660517", "R-HSA-1632852", "R-CEL-1660517", "R-SPO-1660517", "R-SCE-5668599", "R-DDI-1660514", "R-MMU-168138", "R-MMU-1660517", "R-SPO-1632852"], "pathways": ["PWY-6352:t:3-phosphoinositide biosynthesis", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-RNO-109704:r:PI3K Cascade", "R-CEL-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-1632852:r:Macroautophagy", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DDI-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-DDI-1632852:r:Macroautophagy", "R-MMU-109704:r:PI3K Cascade", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-109704:r:PI3K Cascade", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-1632852:r:Macroautophagy", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-1632852:r:Macroautophagy", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-1632852:r:Macroautophagy"], "type": "Family"}, "IPR008291": {"description": "Glucoamylase, starch-binding", "go_ids": ["GO:0000272", "GO:0004339", "GO:2001070"], "go_terms": ["GO:0000272:polysaccharide catabolic process:P", "GO:0004339:glucan 1,4-alpha-glucosidase activity:F", "GO:2001070:starch binding:F"], "name": "Glucoamylase_SBD", "pathway_ids": ["PWY-5941"], "pathways": ["PWY-5941:t:glycogen degradation II"], "type": "Family"}, "IPR008292": {"description": "Haptoglobin", "go_ids": ["GO:0005576", "GO:0030492"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0030492:hemoglobin binding:F"], "name": "Haptoglobin", "pathway_ids": ["R-HSA-2168880", "R-MMU-6798695", "R-SSC-6798695", "R-SSC-2168880", "R-MMU-2168880", "R-RNO-6798695", "R-RNO-2168880"], "pathways": ["R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-SSC-2168880:r:Scavenging of heme from plasma", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-2168880:r:Scavenging of heme from plasma"], "type": "Family"}, "IPR008294": {"description": "Meprin alpha/beta subunit", "go_ids": ["GO:0008270", "GO:0004222", "GO:0006508", "GO:0016020"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0016020:membrane:C"], "name": "Meprin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008296": {"description": "Tissue factor pathway inhibitor-like", "go_ids": ["GO:0005576", "GO:0030414", "GO:0010466"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0030414:peptidase inhibitor activity:F", "GO:0010466:negative regulation of peptidase activity:P"], "name": "TFPI-like", "pathway_ids": ["R-MMU-140834", "R-HSA-9925563", "R-RNO-140834", "R-HSA-140834"], "pathways": ["R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation"], "type": "Family"}, "IPR008297": {"description": "Notch", "go_ids": ["GO:0050793", "GO:0007219", "GO:0016020", "GO:0030154"], "go_terms": ["GO:0050793:regulation of developmental process:P", "GO:0007219:Notch signaling pathway:P", "GO:0016020:membrane:C", "GO:0030154:cell differentiation:P"], "name": "Notch", "pathway_ids": ["R-XTR-2979096", "R-HSA-8941856", "R-HSA-9604323", "R-HSA-2122948", "R-RNO-9017802", "R-MMU-2122947", "R-XTR-8941856", "R-MMU-2122948", "R-HSA-9818749", "R-XTR-2122948", "R-HSA-9824272", "R-XTR-2197563", "R-XTR-1912420", "R-HSA-1912408", "R-RNO-350054", "R-MMU-1912420", "R-HSA-5083630", "R-HSA-2979096", "R-HSA-9017802", "R-HSA-9818030", "R-HSA-9013700", "R-MMU-9013507", "R-RNO-1912420", "R-HSA-2691232", "R-HSA-9013507", "R-HSA-2122947", "R-MMU-9013700", "R-HSA-1912420", "R-HSA-9013508", "R-HSA-210744", "R-HSA-2894862", "R-XTR-9013507", "R-RNO-9013507", "R-MMU-9017802", "R-HSA-350054", "R-MMU-9604323", "R-HSA-9013695", "R-HSA-2644607", "R-HSA-2660826", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-1912399", "R-XTR-9017802"], "pathways": ["R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9824272:r:Somitogenesis", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-XTR-9017802:r:Noncanonical activation of NOTCH3"], "type": "Family"}, "IPR008299": {"description": "Prephenate dehydrogenase/arogenate dehydrogenase", "go_ids": [], "go_terms": [], "name": "Prep_DH/arog_DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008300": {"description": "Phosphate propanoyltransferase", "go_ids": ["GO:0016747"], "go_terms": ["GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "PTAC", "pathway_ids": ["PWY-5437", "PWY-7013"], "pathways": ["PWY-5437:t:L-threonine degradation I", "PWY-7013:t:(S)-propane-1,2-diol degradation"], "type": "Family"}, "IPR008302": {"description": "Peptidoglycan beta-N-acetylmuramidase NamZ", "go_ids": ["GO:0033922"], "go_terms": ["GO:0033922:peptidoglycan beta-N-acetylmuramidase activity:F"], "name": "NamZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008303": {"description": "Methanogenesis marker protein 14", "go_ids": [], "go_terms": [], "name": "Methan_mark_14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008304": {"description": "Uncharacterised conserved protein UCP017998", "go_ids": [], "go_terms": [], "name": "UCP017998", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008306": {"description": "Uncharacterised conserved protein UCP018008", "go_ids": [], "go_terms": [], "name": "UCP018008", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008307": {"description": "Uncharacterised conserved protein UCP018957", "go_ids": [], "go_terms": [], "name": "UCP018957", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008308": {"description": "YpbB protein", "go_ids": [], "go_terms": [], "name": "YpbB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008309": {"description": "Probable chaperone-like protein YdbL", "go_ids": [], "go_terms": [], "name": "YdbL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008310": {"description": "UPF0735 ACT domain-containing protein", "go_ids": [], "go_terms": [], "name": "UPF0735_ACT_dom-cont", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008311": {"description": "Uncharacterised conserved protein UCP028101", "go_ids": [], "go_terms": [], "name": "UCP028101", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008312": {"description": "Type VI secretion system sheath protein TssB1", "go_ids": [], "go_terms": [], "name": "T6SS_TssB1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008313": {"description": "Metal-independent alpha-mannosidase", "go_ids": [], "go_terms": [], "name": "GH125", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008314": {"description": "N(4)-acetylcytidine amidohydrolase", "go_ids": [], "go_terms": [], "name": "AC4CH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008316": {"description": "Uncharacterised conserved protein UCP029876", "go_ids": [], "go_terms": [], "name": "UCP029876", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008317": {"description": "Uncharacterised conserved protein UCP030561", "go_ids": [], "go_terms": [], "name": "UCP030561", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008318": {"description": "Uncharacterised conserved protein UCP030820", "go_ids": [], "go_terms": [], "name": "UCP030820", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008319": {"description": "GyrI-like cyclopropanoid cyclopropyl hydrolase Lin2189-like", "go_ids": [], "go_terms": [], "name": "GyrI-like_CCH_Lin2189-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008320": {"description": "Uncharacterised conserved protein UCP032025", "go_ids": [], "go_terms": [], "name": "UCP032025", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008321": {"description": "Uncharacterised conserved protein UCP032146", "go_ids": [], "go_terms": [], "name": "UCP032146", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008322": {"description": "Uncharacterised protein family UPF0261", "go_ids": [], "go_terms": [], "name": "UPF0261", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008323": {"description": "Uncharacterised conserved protein UCP033563", "go_ids": [], "go_terms": [], "name": "UCP033563", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008325": {"description": "EipA-like", "go_ids": [], "go_terms": [], "name": "EipA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008326": {"description": "Pyruvate dehydrogenase inhibitor-like", "go_ids": [], "go_terms": [], "name": "PdhI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008327": {"description": "Signal transduction response regulator, antiterminator", "go_ids": [], "go_terms": [], "name": "Sig_transdc_resp-reg_antiterm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008330": {"description": "Peptidase M17, peptidase B", "go_ids": ["GO:0005737", "GO:0030145", "GO:0006508", "GO:0070006"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0030145:manganese ion binding:F", "GO:0006508:proteolysis:P", "GO:0070006:metalloaminopeptidase activity:F"], "name": "Pept_M17_PepB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008331": {"description": "Ferritin/DPS domain", "go_ids": ["GO:0008199"], "go_terms": ["GO:0008199:ferric iron binding:F"], "name": "Ferritin_DPS_dom", "pathway_ids": ["R-HSA-6798695", "R-HSA-3000480", "R-RNO-917937", "R-GGA-917937", "R-MMU-432722", "R-BTA-6798695", "R-CFA-432722", "R-HSA-1222449", "R-CFA-917937", "R-GGA-6798695", "R-MMU-917937", "R-BTA-917937", "R-HSA-917937", "R-GGA-432722", "R-MMU-6798695", "R-CFA-6798695", "R-HSA-432722", "R-RNO-6798695", "R-RNO-432722"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-RNO-917937:r:Iron uptake and transport", "R-GGA-917937:r:Iron uptake and transport", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-CFA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-CFA-917937:r:Iron uptake and transport", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-917937:r:Iron uptake and transport", "R-BTA-917937:r:Iron uptake and transport", "R-HSA-917937:r:Iron uptake and transport", "R-GGA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-6798695:r:Neutrophil degranulation", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR008332": {"description": "Methylguanine DNA methyltransferase, ribonuclease-like domain", "go_ids": ["GO:0003908", "GO:0006281"], "go_terms": ["GO:0003908:methylated-DNA-[protein]-cysteine S-methyltransferase activity:F", "GO:0006281:DNA repair:P"], "name": "MethylG_MeTrfase_N", "pathway_ids": ["R-HSA-5657655"], "pathways": ["R-HSA-5657655:r:MGMT-mediated DNA damage reversal"], "type": "Domain"}, "IPR008333": {"description": "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain", "go_ids": [], "go_terms": [], "name": "Cbr1-like_FAD-bd_dom", "pathway_ids": ["R-HSA-6798695", "R-MMU-1237044", "R-MMU-196836", "R-RNO-1237044", "R-HSA-211945", "R-RNO-196836", "R-BTA-6798695", "R-BTA-211945", "R-HSA-1237044", "R-CFA-196836", "R-RNO-114608", "R-RNO-211945", "R-HSA-114608", "R-BTA-114608", "R-BTA-196836", "R-CFA-211945", "R-XTR-1237044", "R-HSA-196836", "R-MMU-6798695", "R-CFA-6798695", "R-BTA-1237044", "R-RNO-6798695", "R-MMU-211945", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-RNO-196836:r:Vitamin C (ascorbate) metabolism", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-211945:r:Phase I - Functionalization of compounds", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-CFA-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-114608:r:Platelet degranulation", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-BTA-196836:r:Vitamin C (ascorbate) metabolism", "R-CFA-211945:r:Phase I - Functionalization of compounds", "R-XTR-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-6798695:r:Neutrophil degranulation", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR008334": {"description": "5'-Nucleotidase, C-terminal", "go_ids": ["GO:0009166", "GO:0016787"], "go_terms": ["GO:0009166:nucleotide catabolic process:P", "GO:0016787:hydrolase activity:F"], "name": "5'-Nucleotdase_C", "pathway_ids": ["R-MMU-196807", "R-HSA-74259", "R-RNO-74259", "R-HSA-9660826", "R-HSA-196807", "R-MMU-74259", "R-RNO-73621", "R-HSA-73621", "R-MMU-73621", "R-RNO-196807"], "pathways": ["R-MMU-196807:r:Nicotinate metabolism", "R-HSA-74259:r:Purine catabolism", "R-RNO-74259:r:Purine catabolism", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-74259:r:Purine catabolism", "R-RNO-73621:r:Pyrimidine catabolism", "R-HSA-73621:r:Pyrimidine catabolism", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-196807:r:Nicotinate metabolism"], "type": "Domain"}, "IPR008336": {"description": "DNA topoisomerase I, DNA binding, eukaryotic-type", "go_ids": ["GO:0003677", "GO:0003917", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003917:DNA topoisomerase type I (single strand cut, ATP-independent) activity:F", "GO:0006265:DNA topological change:P"], "name": "TopoI_DNA-bd_euk", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-HSA-4615885", "R-SPO-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Domain"}, "IPR008337": {"description": "Capsule biosynthesis protein CapB", "go_ids": ["GO:0016020", "GO:0045227"], "go_terms": ["GO:0016020:membrane:C", "GO:0045227:capsule polysaccharide biosynthetic process:P"], "name": "Capsule_biosynth_CapB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008338": {"description": "Capsule biosynthesis protein CapC", "go_ids": ["GO:0016020", "GO:0045227"], "go_terms": ["GO:0016020:membrane:C", "GO:0045227:capsule polysaccharide biosynthetic process:P"], "name": "Capsule_biosynth_CapC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008343": {"description": "Mitogen-activated protein (MAP) kinase phosphatase", "go_ids": ["GO:0006470", "GO:0017017"], "go_terms": ["GO:0006470:protein dephosphorylation:P", "GO:0017017:MAP kinase tyrosine/serine/threonine phosphatase activity:F"], "name": "MKP", "pathway_ids": ["R-GGA-437980", "R-HSA-202670", "R-BTA-202670", "R-CEL-5675221", "R-BTA-112409", "R-RNO-5675221", "R-CEL-202670", "R-DME-202670", "R-HSA-9636569", "R-RNO-112409", "R-RNO-202670", "R-DME-5675221", "R-BTA-5675221", "R-HSA-9652817", "R-MMU-112409", "R-HSA-112409", "R-CEL-112409", "R-GGA-437986", "R-MMU-202670", "R-DME-112409", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-HSA-202670:r:ERKs are inactivated", "R-BTA-202670:r:ERKs are inactivated", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-BTA-112409:r:RAF-independent MAPK1/3 activation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-202670:r:ERKs are inactivated", "R-DME-202670:r:ERKs are inactivated", "R-HSA-9636569:r:Suppression of autophagy", "R-RNO-112409:r:RAF-independent MAPK1/3 activation", "R-RNO-202670:r:ERKs are inactivated", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9652817:r:Signaling by MAPK mutants", "R-MMU-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-112409:r:RAF-independent MAPK1/3 activation", "R-CEL-112409:r:RAF-independent MAPK1/3 activation", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-MMU-202670:r:ERKs are inactivated", "R-DME-112409:r:RAF-independent MAPK1/3 activation", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR008356": {"description": "Protein-tyrosine phosphatase, KIM-containing", "go_ids": ["GO:0004725", "GO:0006470"], "go_terms": ["GO:0004725:protein tyrosine phosphatase activity:F", "GO:0006470:protein dephosphorylation:P"], "name": "Tyr_Pase_KIM-con", "pathway_ids": ["R-HSA-9008059", "R-MMU-5675221", "R-RNO-5675221", "R-HSA-5675221"], "pathways": ["R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR008357": {"description": "Lantibiotic leader peptide-processing serine protease", "go_ids": ["GO:0004252", "GO:0006508"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Lanit_process", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008359": {"description": "Linker-for-activation of T cells (LAT) protein", "go_ids": ["GO:0007165", "GO:0016020"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0016020:membrane:C"], "name": "Linker_for_activat_Tcells_prot", "pathway_ids": ["R-MMU-202433", "R-MMU-114604", "R-HSA-202433", "R-HSA-2424491", "R-HSA-2871796", "R-HSA-2871809", "R-RNO-202433", "R-MMU-2454202", "R-RNO-2871809", "R-HSA-5673001", "R-MMU-2871796", "R-RNO-114604", "R-HSA-2454202", "R-RNO-2454202", "R-RNO-2424491", "R-MMU-2871809", "R-MMU-2424491", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-114604", "R-RNO-2871796"], "pathways": ["R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-2424491:r:DAP12 signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-RNO-2871796:r:FCERI mediated MAPK activation"], "type": "Family"}, "IPR008365": {"description": "Prostanoid receptor", "go_ids": ["GO:0007186", "GO:0016020"], "go_terms": ["GO:0007186:G protein-coupled receptor 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receptor", "R-BTA-391908:r:Prostanoid ligand receptors", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-391908:r:Prostanoid ligand receptors", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-BTA-416476:r:G alpha (q) signalling events", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-391908:r:Prostanoid ligand receptors", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-BTA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-428930:r:Thromboxane signalling through TP receptor", "R-RNO-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-MMU-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CFA-416476:r:G alpha (q) signalling events", "R-HSA-428930:r:Thromboxane signalling through TP receptor", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Family"}, "IPR008366": {"description": "Nuclear factor of activated T cells (NFAT)", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "NFAT", "pathway_ids": ["R-HSA-2025928", "R-HSA-8877330", "R-MMU-5607763", "R-HSA-9942503", "R-RNO-2025928", "R-MMU-2871809", "R-HSA-5607763", "R-MMU-4086398", "R-MMU-2025928", "R-HSA-2871809", "R-HSA-4086398", "R-RNO-2871809", "R-RNO-5607763"], "pathways": ["R-HSA-2025928:r:Calcineurin activates NFAT", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-4086398:r:Ca2+ pathway", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation"], "type": "Family"}, "IPR008374": {"description": "SF-assemblin/beta-giardin", "go_ids": ["GO:0005200"], "go_terms": ["GO:0005200:structural constituent of cytoskeleton:F"], "name": "SF_assemblin/giardin_b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008379": {"description": "Band 4.1, C-terminal", "go_ids": ["GO:0003779", "GO:0005198", "GO:0005856"], "go_terms": ["GO:0003779:actin binding:F", "GO:0005198:structural molecule activity:F", "GO:0005856:cytoskeleton:C"], "name": "Band_4.1_C", "pathway_ids": ["R-HSA-399719", "R-BTA-6794361", "R-HSA-9662360", "R-HSA-9662361", "R-MMU-6794361", "R-DME-6794361", "R-RNO-6794361", "R-RNO-399719", "R-MMU-399719", "R-HSA-6794361"], "pathways": ["R-HSA-399719:r:Trafficking of AMPA receptors", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-DME-6794361:r:Neurexins and neuroligins", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-HSA-6794361:r:Neurexins and neuroligins"], "type": "Domain"}, "IPR008380": {"description": "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase", "go_ids": [], "go_terms": [], "name": "HAD-SF_hydro_IG_5-nucl", "pathway_ids": ["R-DDI-9755088", "R-RNO-74259", "R-RNO-9755088", "R-MMU-2161541", "R-BTA-2161541", "R-RNO-2161541", "R-DDI-2161541", "R-GGA-421178", "R-HSA-2161541", "R-XTR-9755088", "R-MMU-9755088", "R-BTA-9755088", "R-XTR-74259", "R-BTA-74259", "R-HSA-74259", "R-MMU-74259", "R-HSA-9755088", "R-XTR-2161541", "R-DDI-74259"], "pathways": 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"R-DRE-9854311", "R-HSA-9854311", "R-BTA-9854311", "R-MMU-9854311"], "pathways": ["R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Family"}, "IPR008382": {"description": "SPHK1-interactor/A-kinase anchor 110kDa", "go_ids": [], "go_terms": [], "name": "SPHK1-interactor_AKAP_110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008383": {"description": "Apoptosis inhibitory 5", "go_ids": [], "go_terms": [], "name": "API5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008384": {"description": "Actin-related protein 2/3 complex subunit 4", "go_ids": ["GO:0030041", "GO:0015629", "GO:0005885", "GO:0034314"], "go_terms": ["GO:0030041:actin filament 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operon C, C-terminal", "go_ids": ["GO:0019867", "GO:0030244"], "go_terms": ["GO:0019867:outer membrane:C", "GO:0030244:cellulose biosynthetic process:P"], "name": "BCSC_C", "pathway_ids": ["R-HSA-9931953"], "pathways": ["R-HSA-9931953:r:Biofilm formation"], "type": "Domain"}, "IPR008412": {"description": "Integrin-binding sialoprotein", "go_ids": ["GO:0001503", "GO:0005576", "GO:0007155"], "go_terms": ["GO:0001503:ossification:P", "GO:0005576:extracellular region:C", "GO:0007155:cell adhesion:P"], "name": "IBSP", "pathway_ids": ["R-RNO-216083", "R-HSA-216083", "R-BTA-216083", "R-HSA-3000178", "R-MMU-216083"], "pathways": ["R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-216083:r:Integrin cell surface interactions"], "type": "Family"}, "IPR008414": {"description": "Hemolysin BL-binding component", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "HBL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008415": {"description": "Nucleopolyhedrovirus late expression factor 3", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Baculo_LEF-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008416": {"description": "Baculovirus VP1054", "go_ids": [], "go_terms": [], "name": "Baculo_VP1054", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008417": {"description": "B-cell receptor-associated protein 29/31", "go_ids": ["GO:0005783", "GO:0006886", "GO:0016020"], "go_terms": ["GO:0005783:endoplasmic reticulum:C", "GO:0006886:intracellular protein transport:P", "GO:0016020:membrane:C"], "name": "BAP29/BAP31", "pathway_ids": ["R-HSA-983170", "R-SCE-75153", "R-HSA-8980692", "R-MMU-983170", "R-MMU-111465", "R-HSA-111465", "R-MMU-8980692", "R-HSA-9833110", "R-SPO-75153", "R-HSA-75153", "R-DDI-75153", "R-MMU-75153"], "pathways": ["R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-75153:r:Apoptotic execution phase", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9833110:r:RSV-host interactions", "R-SPO-75153:r:Apoptotic execution phase", "R-HSA-75153:r:Apoptotic execution phase", "R-DDI-75153:r:Apoptotic execution phase", "R-MMU-75153:r:Apoptotic execution phase"], "type": "Family"}, "IPR008419": {"description": "Benyvirus p25/p26", "go_ids": [], "go_terms": [], "name": "BNYVV_p25/p26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008420": {"description": "Borrelia membrane P13", "go_ids": [], "go_terms": [], "name": "Borrelia_P13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008421": {"description": "Borrelia lipoprotein paralogus family 54/60", "go_ids": [], "go_terms": [], "name": "Borrelia_lipoprotein_PFam54/60", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008422": {"description": "KN homeodomain", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "KN_HD", "pathway_ids": ["R-MMU-2173795", "R-HSA-9830674", "R-HSA-9013508", "R-HSA-2173795", "R-DME-390193", "R-GGA-2173795", "R-HSA-9831926", "R-HSA-452723", "R-HSA-9764725", "R-HSA-2173796", "R-HSA-5617472"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-390193:r:Transcriptional activation by YKI", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9831926:r:Nephron development", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "type": "Domain"}, "IPR008423": {"description": "P21 molecular chaperone, Bacillus thuringiensis", "go_ids": [], "go_terms": [], "name": "P21_molc_chaperone_B_thur", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008424": {"description": "Immunoglobulin C2-set", "go_ids": ["GO:0007155", "GO:0016020"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0016020:membrane:C"], "name": "Ig_C2-set", "pathway_ids": ["R-MMU-8856828", "R-HSA-449836", "R-RNO-216083", "R-MMU-8856825", "R-HSA-202433", "R-HSA-8856828", "R-RNO-202433", "R-MMU-202430", "R-HSA-202427", "R-RNO-202427", "R-RNO-202424", "R-RNO-8856828", "R-HSA-202430", "R-MMU-449836", "R-MMU-202424", "R-HSA-173107", "R-MMU-389948", "R-MMU-202433", "R-RNO-8856825", "R-HSA-216083", "R-HSA-1462054", "R-RNO-198933", "R-HSA-167590", "R-HSA-6785807", "R-RNO-1462054", "R-MMU-198933", "R-HSA-202424", "R-HSA-8856825", "R-HSA-877300", "R-RNO-389948", "R-HSA-180534", "R-MMU-216083", "R-MMU-202427", "R-HSA-198933", "R-MMU-1462054", "R-RNO-202430", "R-HSA-389948", "R-RNO-449836", "R-HSA-202733"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-216083:r:Integrin cell surface interactions", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-202424:r:Downstream TCR signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-449836:r:Other interleukin signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-173107:r:Binding and entry of HIV virion", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-202433:r:Generation of second messenger molecules", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-1462054:r:Alpha-defensins", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-1462054:r:Alpha-defensins", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-877300:r:Interferon gamma signaling", "R-RNO-389948:r:Co-inhibition by PD-1", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-1462054:r:Alpha-defensins", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-389948:r:Co-inhibition by PD-1", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR008425": {"description": "Cyclin-dependent kinase inhibitor 3", "go_ids": ["GO:0004721", "GO:0004725"], "go_terms": ["GO:0004721:phosphoprotein phosphatase activity:F", "GO:0004725:protein tyrosine phosphatase activity:F"], "name": "CDK_inhib_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008426": {"description": "Centromere protein H, C-terminal", "go_ids": ["GO:0051382", "GO:0000776"], "go_terms": ["GO:0051382:kinetochore assembly:P", "GO:0000776:kinetochore:C"], "name": "CENP-H_C", "pathway_ids": ["R-MMU-2500257", "R-HSA-606279", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-MMU-606279", "R-BTA-5663220", "R-HSA-9648025", "R-MMU-68877", "R-BTA-606279", "R-GGA-2500257", "R-GGA-141444", "R-BTA-2467813", "R-HSA-68877", "R-GGA-9648025", "R-GGA-606279", "R-BTA-2500257", "R-GGA-5663220", "R-HSA-5663220", "R-GGA-2467813", "R-BTA-9648025", "R-BTA-141444", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR008427": {"description": "Extracellular membrane protein, CFEM domain", "go_ids": [], "go_terms": [], "name": "Extracellular_membr_CFEM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008428": {"description": "Chondroitin N-acetylgalactosaminyltransferase", "go_ids": ["GO:0032580"], "go_terms": ["GO:0032580:Golgi cisterna membrane:C"], "name": "Chond_GalNAc", "pathway_ids": ["R-MMU-2022870", "R-HSA-2022870", "R-HSA-3595177"], "pathways": ["R-MMU-2022870:r:CS-GAG biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-HSA-3595177:r:Defective CHSY1 causes TPBS"], "type": "Family"}, "IPR008429": {"description": "Cleft lip and palate transmembrane 1", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "CLPTM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008430": {"description": "Cytotoxic necrotizing factor, Rho-activating domain", "go_ids": [], "go_terms": [], "name": "CNF_Rho-act", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008431": {"description": "Cyclic nucleotide phosphodiesterase", "go_ids": ["GO:0004113", "GO:0009214", "GO:0016020"], "go_terms": ["GO:0004113:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity:F", "GO:0009214:cyclic nucleotide catabolic process:P", "GO:0016020:membrane:C"], "name": "CNPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008432": {"description": "Cytochrome c oxidase subunit 5c", "go_ids": [], "go_terms": [], "name": "COX5C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008433": {"description": "Cytochrome C oxidase, subunit VIIB", "go_ids": ["GO:0006123"], "go_terms": ["GO:0006123:mitochondrial electron transport, cytochrome c to oxygen:P"], "name": "Cyt_c_oxidase_suVIIB", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-HSA-9707564", "R-MMU-611105", "R-MMU-5628897", "R-RNO-5628897", "R-MMU-9864848", "R-RNO-9707564", "R-HSA-5628897", "R-MMU-9707564"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR008434": {"description": "Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase", "go_ids": ["GO:0015979", "GO:0015995", "GO:0048529", "GO:0046872"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0015995:chlorophyll biosynthetic process:P", "GO:0048529:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity:F", "GO:0046872:metal ion binding:F"], "name": "AcsF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008435": {"description": "Corticotropin-releasing factor-binding protein", "go_ids": ["GO:0051424"], "go_terms": ["GO:0051424:corticotropin-releasing hormone binding:F"], "name": "CRF-bd", "pathway_ids": ["R-HSA-373080", "R-RNO-373080", "R-MMU-373080"], "pathways": ["R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-373080:r:Class B/2 (Secretin family receptors)"], "type": "Family"}, "IPR008436": {"description": "Sulfur-rich protein", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "SRP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008437": {"description": "Minor structural protein VP2, calicivirus", "go_ids": [], "go_terms": [], "name": "Minor_structural_calicivir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008438": {"description": "Myozenin", "go_ids": ["GO:0030018"], "go_terms": ["GO:0030018:Z disc:C"], "name": "MYOZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008439": {"description": "Major outer membrane, Campylobacter", "go_ids": [], "go_terms": [], "name": "Campylo_MOMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008440": {"description": "Agglutinin, central repeat", "go_ids": ["GO:0007155"], "go_terms": ["GO:0007155:cell adhesion:P"], "name": "ALS_central", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR008441": {"description": "AfumC-like glycosyltransferase", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "AfumC-like_glycosyl_Trfase", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR008442": {"description": "Propeptide, carboxypeptidase Y", "go_ids": ["GO:0004185", "GO:0005773"], "go_terms": ["GO:0004185:serine-type carboxypeptidase activity:F", "GO:0005773:vacuole:C"], "name": "Propeptide_carboxypepY", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008444": {"description": "Chlamydia virulence plasmid protein pGP3", "go_ids": [], "go_terms": [], "name": "Chlamydia_pGP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008445": {"description": "Core protein A15", "go_ids": [], "go_terms": [], "name": "A15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008446": {"description": "Chordopoxvirus G2", "go_ids": [], "go_terms": [], "name": "Chordopox_G2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008447": {"description": "Protein L2", "go_ids": [], "go_terms": [], "name": "Prot_L2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008448": {"description": "DNA-directed RNA polymerase, 7kDa polypeptide, chordopoxviral", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "RNA_pol_7kDa_chordopoxvir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008449": {"description": "Chorion S36/S38", "go_ids": [], "go_terms": [], "name": "Chorion_S36/S28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008450": {"description": "Chorion S16", "go_ids": ["GO:0007275", "GO:0042600"], "go_terms": ["GO:0007275:multicellular organism development:P", "GO:0042600:egg chorion:C"], "name": "Chorion_S16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008451": {"description": "Chromadorea ALT", "go_ids": [], "go_terms": [], "name": "Chromadorea_ALT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008452": {"description": "Citrus tristeza virus P18", "go_ids": [], "go_terms": [], "name": "CTV_P18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008453": {"description": "Clavanin", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Clavanin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008454": {"description": "Collagen-binding surface protein Cna-like, B-type domain", "go_ids": [], "go_terms": [], "name": "Collagen-bd_Cna-like_B-typ_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008455": {"description": "HssA/B family related", "go_ids": [], "go_terms": [], "name": "HssA/B-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008456": {"description": "Collagen binding domain", "go_ids": ["GO:0005518"], "go_terms": ["GO:0005518:collagen binding:F"], "name": "Collagen-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008457": {"description": "Copper resistance protein D domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Cu-R_CopD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008458": {"description": "Accessory protein 5b, avian coronavirus", "go_ids": [], "go_terms": [], "name": "Acc_prot_5b_avian_CoV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008461": {"description": "Lycopene cyclase, pseudomonadota", "go_ids": ["GO:0016117", "GO:0045436"], "go_terms": ["GO:0016117:carotenoid biosynthetic process:P", "GO:0045436:lycopene beta cyclase activity:F"], "name": "CrtY_pseudo", "pathway_ids": ["PWY-7591", "PWY-6279", "PWY-5947", "PWY-7938", "PWY-7947", "PWY-5946", "PWY-7939", "PWY-5943"], "pathways": ["PWY-7591:t:okenone biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-5947:t:lutein biosynthesis", "PWY-7938:t:isorenieratene biosynthesis I (actinobacteria)", "PWY-7947:t:flexixanthin biosynthesis", "PWY-5946:t:alpha-carotene biosynthesis", "PWY-7939:t:chlorobactene biosynthesis", "PWY-5943:t:beta-carotene biosynthesis"], "type": "Family"}, "IPR008462": {"description": "CsbD-like domain", "go_ids": [], "go_terms": [], "name": "CsbD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008463": {"description": "Transcriptional regulator CtsR", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "CtsR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008464": {"description": "Cypovirus polyhedrin, Cypovirus 1 type", "go_ids": [], "go_terms": [], "name": "Cypo_polyhedrin_Cypovirus1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008465": {"description": "Dystroglycan, C-terminal", "go_ids": ["GO:0016010"], "go_terms": ["GO:0016010:dystrophin-associated glycoprotein complex:C"], "name": "DAG1_C", "pathway_ids": ["R-MMU-8932505", "R-HSA-8932505", "R-CFA-9939291", "R-HSA-3000178", "R-HSA-8932504", "R-HSA-5083633", "R-HSA-3000171", "R-HSA-9913351", "R-HSA-9619665", "R-HSA-9010553", "R-MMU-9939291", "R-MMU-9010553", "R-CFA-9913351", "R-HSA-8932506", "R-MMU-9913351", "R-MMU-8932504", "R-CFA-9010553", "R-CFA-8932506", "R-CFA-8932504", "R-HSA-9939291", "R-HSA-5083629", "R-HSA-5083628", "R-CFA-8932505", "R-MMU-8932506"], "pathways": ["R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-CFA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-5083633:r:Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-CFA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-8932506:r:DAG1 core M1 glycosylations", "R-CFA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-5083629:r:Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "R-HSA-5083628:r:Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "R-CFA-8932505:r:DAG1 core M3 glycosylations", "R-MMU-8932506:r:DAG1 core M1 glycosylations"], "type": "Domain"}, "IPR008466": {"description": "Protein phosphatase inhibitor 1", "go_ids": ["GO:0004864", "GO:0007165"], "go_terms": ["GO:0004864:protein phosphatase inhibitor activity:F", "GO:0007165:signal transduction:P"], "name": "PPP1R1A/B/C", "pathway_ids": ["R-MMU-180024", "R-BTA-180024", "R-RNO-180024", "R-HSA-180024"], "pathways": ["R-MMU-180024:r:DARPP-32 events", "R-BTA-180024:r:DARPP-32 events", "R-RNO-180024:r:DARPP-32 events", "R-HSA-180024:r:DARPP-32 events"], "type": "Family"}, "IPR008467": {"description": "Dynein 1 light intermediate chain", "go_ids": ["GO:0007018", "GO:0005868"], "go_terms": ["GO:0007018:microtubule-based movement:P", "GO:0005868:cytoplasmic dynein complex:C"], "name": "Dynein1_light_intermed_chain", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-HSA-9646399", "R-HSA-2132295", "R-SPO-6798695", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-RNO-3371497", "R-DDI-9646399", "R-HSA-3371497", "R-MMU-68877", "R-MMU-6807878", "R-HSA-68877", "R-MMU-2132295", "R-MMU-9648025", "R-HSA-6811436", "R-DDI-6798695", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-MMU-141444", "R-RNO-6807878", "R-HSA-6807878", "R-HSA-141444", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-DDI-6807878", "R-RNO-9646399", "R-MMU-3371497", "R-HSA-5663220", "R-RNO-2467813", "R-RNO-9648025", "R-MMU-6798695", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DDI-9646399:r:Aggrephagy", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-RNO-9646399:r:Aggrephagy", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR008468": {"description": "DNA methyltransferase 1-associated 1", "go_ids": ["GO:0005634", "GO:0045892"], "go_terms": ["GO:0005634:nucleus:C", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "DMAP1", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR008469": {"description": "DREPP family", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "DREPP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008470": {"description": "Uncharacterised protein family Ycf33", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008471": {"description": "MnmC-like methyltransferase", "go_ids": ["GO:0016645"], "go_terms": ["GO:0016645:oxidoreductase activity, acting on the CH-NH group of donors:F"], "name": "MnmC-like_methylTransf", "pathway_ids": ["PWY-7892"], "pathways": ["PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)"], "type": "Domain"}, "IPR008472": {"description": "Domain of unknown function DUF753", "go_ids": [], "go_terms": [], "name": "DUF753", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008473": {"description": "Putative 3TM holin, Phage holin 3", "go_ids": [], "go_terms": [], "name": "Phage_holin_3_7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008474": {"description": "Protein of unknown function DUF755", "go_ids": [], "go_terms": [], "name": "DUF755", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008475": {"description": "Bacterial phospholipase C, C-terminal domain", "go_ids": ["GO:0004629", "GO:0016042"], "go_terms": ["GO:0004629:C-type glycerophospholipase activity:F", "GO:0016042:lipid catabolic process:P"], "name": "PLipase_C_C", "pathway_ids": ["PWY-7782", "PWY-7783", "PWY-8052"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7783:t:plasmalogen degradation", "PWY-8052:t:2-arachidonoylglycerol biosynthesis"], "type": "Domain"}, "IPR008476": {"description": "Protein PBDC1, metazoa/fungi", "go_ids": [], "go_terms": [], "name": "PBDC1_metazoa/fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008477": {"description": "Tumor necrosis factor alpha-induced protein 8-like", "go_ids": ["GO:0042981"], "go_terms": ["GO:0042981:regulation of apoptotic process:P"], "name": "TNFAIP8-like", "pathway_ids": ["R-DME-1483255", "R-XTR-1483255", "R-BTA-1483255", "R-DRE-1483255", "R-RNO-1483255", "R-MMU-1483255", "R-GGA-1483255", "R-HSA-1483255"], "pathways": ["R-DME-1483255:r:PI Metabolism", "R-XTR-1483255:r:PI Metabolism", "R-BTA-1483255:r:PI Metabolism", "R-DRE-1483255:r:PI Metabolism", "R-RNO-1483255:r:PI Metabolism", "R-MMU-1483255:r:PI Metabolism", "R-GGA-1483255:r:PI Metabolism", "R-HSA-1483255:r:PI Metabolism"], "type": "Family"}, "IPR008478": {"description": "Protein of unknown function DUF759, Borrelia species", "go_ids": [], "go_terms": [], "name": "DUF759_BOR_spp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008479": {"description": "Protein of unknown function DUF760", "go_ids": [], "go_terms": [], "name": "DUF760", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008480": {"description": "Protein of unknown function DUF761, plant", "go_ids": [], "go_terms": [], "name": "DUF761_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008481": {"description": "Protein of unknown function DUF762, Coxiella burnetii", "go_ids": [], "go_terms": [], "name": "DUF762_COXBU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008482": {"description": "Protein of unknown function DUF763", "go_ids": [], "go_terms": [], "name": "DUF763", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008483": {"description": "Protein of unknown function DUF764, Borrelia species", "go_ids": [], "go_terms": [], "name": "DUF764_BOR_spp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008484": {"description": "Circovirus Orf6", "go_ids": [], "go_terms": [], "name": "Circovirus_Orf6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008485": {"description": "JNK1/MAPK8-associated membrane protein", "go_ids": ["GO:0016020", "GO:0006986"], "go_terms": ["GO:0016020:membrane:C", "GO:0006986:response to unfolded protein:P"], "name": "JAMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008486": {"description": "Protein of unknown function DUF768", "go_ids": [], "go_terms": [], "name": "DUF768", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008487": {"description": "Protein of unknown function DUF769", "go_ids": [], "go_terms": [], "name": "DUF769", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008489": {"description": "Protein of unknown function DUF771", "go_ids": [], "go_terms": [], "name": "DUF771", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008490": {"description": "Transposase InsH, N-terminal", "go_ids": [], "go_terms": [], "name": "Transposase_InsH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008491": {"description": "CDK5 regulatory subunit-associated protein 3", "go_ids": [], "go_terms": [], "name": "CDK5RAP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008492": {"description": "Rv2714-like", "go_ids": [], "go_terms": [], "name": "Rv2714-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008493": {"description": "Hikeshi-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Hikeshi-like_N", "pathway_ids": ["R-SCE-3371453", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-DME-3371453", "R-DDI-3371453", "R-BTA-3371453", "R-XTR-3371453", "R-DRE-3371453", "R-MMU-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DDI-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR008494": {"description": "Protein of unknown function DUF776", "go_ids": [], "go_terms": [], "name": "DUF776", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008495": {"description": "Protein of unknown function DUF777, Borrelia species", "go_ids": [], "go_terms": [], "name": "DUF777_BOR_spp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008496": {"description": "TMEM222/RTE1", "go_ids": [], "go_terms": [], "name": "TMEM222/RTE1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008497": {"description": "Protein of unknown function DUF779", "go_ids": [], "go_terms": [], "name": "DUF779", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008498": {"description": "Protein of unknown function DUF780, Caenorhabditis species", "go_ids": [], "go_terms": [], "name": "DUF780_CAE_spp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008499": {"description": "Leg1", "go_ids": [], "go_terms": [], "name": "Leg1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008500": {"description": "Circovirus Orf3", "go_ids": [], "go_terms": [], "name": "Circovirus_Orf3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008501": {"description": "THO complex subunit 7/Mft1", "go_ids": ["GO:0000445", "GO:0006397"], "go_terms": ["GO:0000445:THO complex part of transcription export complex:C", "GO:0006397:mRNA processing:P"], "name": "THOC7/Mft1", "pathway_ids": ["R-DRE-159236", "R-DRE-73856", "R-MMU-72187", "R-BTA-73856", "R-BTA-159236", "R-HSA-73856", "R-HSA-159236", "R-HSA-72187", "R-MMU-73856", "R-DME-159236", "R-DME-73856", "R-MMU-159236"], "pathways": ["R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR008502": {"description": "Prolamin-like domain", "go_ids": [], "go_terms": [], "name": "Prolamin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008503": {"description": "Retropepsin-like aspartic endopeptidase RimB", "go_ids": [], "go_terms": [], "name": "Asp_endopeptidase_RimB", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis"], "type": "Domain"}, "IPR008504": {"description": "ER membrane protein complex subunit 6", "go_ids": ["GO:0072546", "GO:0005783", "GO:0016020"], "go_terms": ["GO:0072546:EMC complex:C", "GO:0005783:endoplasmic reticulum:C", "GO:0016020:membrane:C"], "name": "Emc6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008505": {"description": "Domain of unknown function DUF787", "go_ids": [], "go_terms": [], "name": "DUF787", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008506": {"description": "SRP-independent targeting protein 2/TMEM208", "go_ids": [], "go_terms": [], "name": "SND2/TMEM208", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008507": {"description": "Protein of unknown function DUF789", "go_ids": [], "go_terms": [], "name": "DUF789", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008508": {"description": "Endonuclease Bax1", "go_ids": [], "go_terms": [], "name": "Bax1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008509": {"description": "Molybdate-anion transporter", "go_ids": ["GO:0015689", "GO:0016020", "GO:0015098"], "go_terms": ["GO:0015689:molybdate ion transport:P", "GO:0016020:membrane:C", "GO:0015098:molybdate ion transmembrane transporter activity:F"], "name": "MOT2/MFSD5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008510": {"description": "Protein of unknown function DUF792, Borrelia species", "go_ids": [], "go_terms": [], "name": "DUF792_BOR_spp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008511": {"description": "Protein ROH1-like", "go_ids": [], "go_terms": [], "name": "ROH1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008513": {"description": "tRNA(Met) cytidine acetate ligase", "go_ids": [], "go_terms": [], "name": "tRNA(Met)_cyd_acetate_ligase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008514": {"description": "Type VI secretion system effector Hcp", "go_ids": [], "go_terms": [], "name": "T6SS_Hcp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008515": {"description": "Prokaryotic ubiquitin-like protein Pup", "go_ids": ["GO:0019941", "GO:0031386", "GO:0070490", "GO:0070628", "GO:0010498"], "go_terms": ["GO:0019941:modification-dependent protein catabolic process:P", "GO:0031386:protein tag activity:F", "GO:0070490:protein pupylation:P", "GO:0070628:proteasome binding:F", "GO:0010498:proteasomal protein catabolic process:P"], "name": "Ubiquitin-like_Pup", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008516": {"description": "Na,K-Atpase Interacting protein", "go_ids": [], "go_terms": [], "name": "Na/K-Atpase_Interacting", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008517": {"description": "Putative lipoprotein GNA1162-like", "go_ids": [], "go_terms": [], "name": "GNA1162-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008518": {"description": "Mff/Tango-11", "go_ids": [], "go_terms": [], "name": "Mff/Tango-11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008519": {"description": "Tandem-repeating region of mucin, epiglycanin-like", "go_ids": [], "go_terms": [], "name": "Tandem-repeating_mucin", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-913709", "R-HSA-977068", "R-HSA-5083625"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC"], "type": "Domain"}, "IPR008520": {"description": "Domain of unknown function DUF802", "go_ids": [], "go_terms": [], "name": "DUF802", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008521": {"description": "Magnesium transporter NIPA", "go_ids": ["GO:0015095", "GO:0015693", "GO:0016020"], "go_terms": ["GO:0015095:magnesium ion transmembrane transporter activity:F", "GO:0015693:magnesium ion transport:P", "GO:0016020:membrane:C"], "name": "Mg_trans_NIPA", "pathway_ids": ["R-HSA-5223345", "R-MMU-5223345", "R-BTA-5223345"], "pathways": ["R-HSA-5223345:r:Miscellaneous transport and binding events", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-BTA-5223345:r:Miscellaneous transport and binding events"], "type": "Family"}, "IPR008523": {"description": "Protein of unknown function DUF805", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "DUF805", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008524": {"description": "Protein of unknown function DUF806", "go_ids": [], "go_terms": [], "name": "DUF806", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008525": {"description": "Protein of unknown function DUF807, Coxiella burnetii", "go_ids": [], "go_terms": [], "name": "DUF807_COXBU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008526": {"description": "Inner membrane protein YedI", "go_ids": [], "go_terms": [], "name": "YedI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008527": {"description": "Protein of unknown function DUF809", "go_ids": [], "go_terms": [], "name": "DUF809", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008528": {"description": "Protein unc-13 homologue", "go_ids": [], "go_terms": [], "name": "PATROL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008530": {"description": "Coiled-coil domain-containing protein 22", "go_ids": [], "go_terms": [], "name": "CCDC22", "pathway_ids": ["R-DRE-8951664", "R-MMU-8951664", "R-BTA-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-DDI-8951664", "R-DME-8951664"], "pathways": ["R-DRE-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation"], "type": "Family"}, "IPR008532": {"description": "NFACT, RNA-binding domain", "go_ids": [], "go_terms": [], "name": "NFACT_RNA-bd", "pathway_ids": ["R-SPO-9954709", "R-SCE-9954709", "R-DME-9954709", "R-HSA-9954709", "R-MMU-9954709"], "pathways": ["R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR008533": {"description": "Protein of unknown function DUF815", "go_ids": [], "go_terms": [], "name": "DUF815", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008534": {"description": "Baculovirus protein of unknown function DUF816", "go_ids": [], "go_terms": [], "name": "DUF816", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008535": {"description": "Protein of unknown function DUF817", "go_ids": [], "go_terms": [], "name": "DUF817", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008536": {"description": "Protein of unknown function DUF818", "go_ids": [], "go_terms": [], "name": "DUF818", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008537": {"description": "Protein of unknown function DUF819", "go_ids": [], "go_terms": [], "name": "DUF819", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008538": {"description": "Putative restriction endonuclease", "go_ids": [], "go_terms": [], "name": "Uma2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008540": {"description": "BES1/BZR1 plant transcription factor, N-terminal", "go_ids": [], "go_terms": [], "name": "BES1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008541": {"description": "InvasinE, adhesion domain", "go_ids": [], "go_terms": [], "name": "InvE_AD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008542": {"description": "Bacterial Immunoglobulin-like 21", "go_ids": [], "go_terms": [], "name": "BIg21", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008544": {"description": "Protein of unknown function DUF826", "go_ids": [], "go_terms": [], "name": "DUF826", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008545": {"description": "WEB family", "go_ids": [], "go_terms": [], "name": "Web", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008546": {"description": "VAN3-binding protein-like, auxin canalisation domain", "go_ids": [], "go_terms": [], "name": "VAN3-bd-like_auxin_canal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008547": {"description": "Protein of unknown function DUF829, TMEM53", "go_ids": [], "go_terms": [], "name": "DUF829_TMEM53", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008550": {"description": "Herpesvirus tegument protein BRRF2-like", "go_ids": [], "go_terms": [], "name": "Herpesvirus_BRRF2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008551": {"description": "Transport and Golgi organisation protein 2", "go_ids": [], "go_terms": [], "name": "TANGO2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008552": {"description": "Domain of unknown function DUF834", "go_ids": [], "go_terms": [], "name": "DUF834", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008553": {"description": "Domain of unknown function DUF835", "go_ids": [], "go_terms": [], "name": "DUF835", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008554": {"description": "Glutaredoxin-like", "go_ids": [], "go_terms": [], "name": "Glutaredoxin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008555": {"description": "SIKE family", "go_ids": [], "go_terms": [], "name": "SIKE", "pathway_ids": ["R-HSA-918233", "R-HSA-933541", "R-HSA-9705671", "R-HSA-5655302", "R-HSA-9692916", "R-HSA-1839117"], "pathways": ["R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Family"}, "IPR008557": {"description": "Alkaline phosphatase PhoX", "go_ids": [], "go_terms": [], "name": "PhoX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008558": {"description": "Minor capsid protein VP2, lagovirus", "go_ids": [], "go_terms": [], "name": "VP2_lagovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008559": {"description": "Calcium load-activated calcium channel", "go_ids": ["GO:0005789", "GO:0032469", "GO:0005262"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0032469:endoplasmic reticulum calcium ion homeostasis:P", "GO:0005262:calcium channel activity:F"], "name": "TMCO1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008560": {"description": "TIM double twin CX3C motif chaperone-like", "go_ids": [], "go_terms": [], "name": "TIMCC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008561": {"description": "Protein Ac76, baculovirus", "go_ids": [], "go_terms": [], "name": "Ac76_baculovir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008562": {"description": "Autographa californica nuclear polyhedrosis virus (AcMNPV), C42", "go_ids": [], "go_terms": [], "name": "AcMNPV_C42", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008563": {"description": "Protein AC81, baculovirus", "go_ids": [], "go_terms": [], "name": "AcMNPV_AC81", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008564": {"description": "Golgi apparatus membrane protein TVP23-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TVP23-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008565": {"description": "TtsA-like, Glycoside hydrolase family 108 domain", "go_ids": [], "go_terms": [], "name": "TtsA-like_GH18_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008566": {"description": "Gammaherpesvirus protein of unknown function DUF848", "go_ids": [], "go_terms": [], "name": "DUF848", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008567": {"description": "Beta-keto acid cleavage enzyme", "go_ids": ["GO:0043720"], "go_terms": ["GO:0043720:3-keto-5-aminohexanoate cleavage activity:F"], "name": "BKACE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008568": {"description": "ER membrane protein complex subunit 3", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "EMC3", "pathway_ids": ["R-BTA-8980692", "R-DRE-8980692", "R-HSA-8980692", "R-MMU-8980692", "R-RNO-8980692"], "pathways": ["R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle"], "type": "Family"}, "IPR008569": {"description": "Protein of unknown function DUF851", "go_ids": [], "go_terms": [], "name": "DUF851", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008570": {"description": "ESCRT-II complex, Vps25 subunit", "go_ids": ["GO:0071985", "GO:0000814"], "go_terms": ["GO:0071985:multivesicular body sorting pathway:P", "GO:0000814:ESCRT II complex:C"], "name": "ESCRT-II_cplx_Vps25-sub", "pathway_ids": ["R-RNO-917729", "R-HSA-917729", "R-HSA-9610379", "R-DRE-917729", "R-MMU-917729", "R-SPO-917729", "R-DDI-917729", "R-BTA-917729", "R-SCE-917729", "R-DME-917729"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SPO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Family"}, "IPR008571": {"description": "Helicase HerA-like", "go_ids": [], "go_terms": [], "name": "HerA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008573": {"description": "Baculovirus U-box/Ring-like", "go_ids": [], "go_terms": [], "name": "Baculovirus_U-box/Ring-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008574": {"description": "Interactor of ZYG-11, nematodes", "go_ids": [], "go_terms": [], "name": "Nematodes_ZYG-11_interact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008576": {"description": "Alpha-N-methyltransferase NTM1", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "MeTrfase_NTM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008577": {"description": "Putative viral structural protein (DUF859)", "go_ids": [], "go_terms": [], "name": "DUF859", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008579": {"description": "(S)-ureidoglycine aminohydrolase, cupin domain", "go_ids": [], "go_terms": [], "name": "UGlyAH_Cupin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008580": {"description": "PPPDE peptidase domain", "go_ids": ["GO:0008233"], "go_terms": ["GO:0008233:peptidase activity:F"], "name": "PPPDE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008581": {"description": "Protein of unknown function DUF863, plant", "go_ids": [], "go_terms": [], "name": "DUF863_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008584": {"description": "CXXC motif containing zinc binding protein, eukaryotic", "go_ids": [], "go_terms": [], "name": "CXXC_Zn-binding_euk", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008585": {"description": "Poly-gamma-glutamate hydrolase", "go_ids": [], "go_terms": [], "name": "Gamma_PGA_hydro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008586": {"description": "Protein of unknown function DUF868, plant", "go_ids": [], "go_terms": [], "name": "DUF868_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008587": {"description": "Filament-like plant protein", "go_ids": [], "go_terms": [], "name": "FPP_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008588": {"description": "Protein of unknown function DUF870, Caenorhabditis species", "go_ids": [], "go_terms": [], "name": "DUF870_CAE_spp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008589": {"description": "6-phospho-N-acetylmuramidase", "go_ids": [], "go_terms": [], "name": "MupG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008590": {"description": "Transmembrane protein 230/134", "go_ids": [], "go_terms": [], "name": "TMEM_230/134", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008591": {"description": "GINS complex subunit Sld5", "go_ids": ["GO:0006261"], "go_terms": ["GO:0006261:DNA-templated DNA replication:P"], "name": "GINS_Sld5", "pathway_ids": ["R-BTA-176974", "R-RNO-176974", "R-SPO-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974"], "pathways": ["R-BTA-176974:r:Unwinding of DNA", "R-RNO-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA"], "type": "Family"}, "IPR008592": {"description": "Protein of unknown function DUF874", "go_ids": [], "go_terms": [], "name": "DUF874", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008593": {"description": "DNA N-6-adenine-methyltransferase", "go_ids": ["GO:0003677", "GO:0009007", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0009007:site-specific DNA-methyltransferase (adenine-specific) activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Dam_MeTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008594": {"description": "Scavenger mRNA decapping enzyme DcpS/DCS2", "go_ids": ["GO:0000290", "GO:0016787"], "go_terms": ["GO:0000290:deadenylation-dependent decapping of nuclear-transcribed mRNA:P", "GO:0016787:hydrolase activity:F"], "name": "DcpS/DCS2", "pathway_ids": ["R-SCE-429958", "R-HSA-429958", "R-SSC-429958", "R-SPO-429958", "R-CEL-429958", "R-RNO-429958", "R-MMU-429958"], "pathways": ["R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SSC-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Family"}, "IPR008595": {"description": "Sensor DegS", "go_ids": ["GO:0007165", "GO:0016301"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0016301:kinase activity:F"], "name": "DegS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008596": {"description": "Accessory protein p30II", "go_ids": [], "go_terms": [], "name": "P30II", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008597": {"description": "Invertebrate-type lysozyme", "go_ids": ["GO:0003796"], "go_terms": ["GO:0003796:lysozyme activity:F"], "name": "Invert_lysozyme", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008598": {"description": "Di19, zinc-binding domain", "go_ids": [], "go_terms": [], "name": "Di19_Zn-bd", "pathway_ids": ["R-BTA-983168", "R-HSA-6798695", "R-SSC-983168", "R-DME-6798695", "R-CEL-6798695", "R-HSA-936440", "R-HSA-9764725", "R-HSA-983168", "R-HSA-6785807", "R-HSA-9764790", "R-MMU-9764725", "R-HSA-9823739", "R-RNO-9764725", "R-MMU-9762293", "R-HSA-9832991", "R-DRE-6798695", "R-HSA-9926550", "R-MMU-983168", "R-MMU-6798695", "R-RNO-983168", "R-HSA-9762293"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9823739:r:Formation of the anterior neural plate", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-9762293:r:Regulation of CDH11 gene transcription", "R-HSA-9832991:r:Formation of the posterior neural plate", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9762293:r:Regulation of CDH11 gene transcription"], "type": "Domain"}, "IPR008599": {"description": "Putative sugar diacid recognition", "go_ids": [], "go_terms": [], "name": "Diacid_rec", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008601": {"description": "Cell-cell adhesion", "go_ids": ["GO:0007155"], "go_terms": ["GO:0007155:cell adhesion:P"], "name": "Dicty_CAD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008602": {"description": "Duffy-antigen binding domain", "go_ids": ["GO:0016020", "GO:0046789"], "go_terms": ["GO:0016020:membrane:C", "GO:0046789:host cell surface receptor binding:F"], "name": "Duffy-antigen-binding", "pathway_ids": ["R-HSA-202733"], "pathways": ["R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR008603": {"description": "Dynactin subunit 4", "go_ids": ["GO:0005869"], "go_terms": ["GO:0005869:dynactin complex:C"], "name": "DCTN4", "pathway_ids": ["R-RNO-6811436", "R-RNO-2132295", "R-SSC-2132295", "R-HSA-2132295", "R-SSC-3371497", "R-SSC-6807878", "R-RNO-6807878", "R-MMU-2132295", "R-HSA-6807878", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-HSA-6811436", "R-MMU-3371497", "R-MMU-6811436"], "pathways": ["R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-2132295:r:MHC class II antigen presentation", "R-SSC-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR008604": {"description": "Microtubule-associated protein 7 family", "go_ids": ["GO:0015630", "GO:0000226"], "go_terms": ["GO:0015630:microtubule cytoskeleton:C", "GO:0000226:microtubule cytoskeleton organization:P"], "name": "MAP7_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008605": {"description": "Extracellular matrix protein 1", "go_ids": ["GO:0005576", "GO:0007165"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0007165:signal transduction:P"], "name": "ECM1", "pathway_ids": ["R-HSA-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR008606": {"description": "Eukaryotic translation initiation factor 4E binding", "go_ids": ["GO:0008190", "GO:0045947"], "go_terms": ["GO:0008190:eukaryotic initiation factor 4E binding:F", "GO:0045947:negative regulation of translational initiation:P"], "name": "EIF4EBP", "pathway_ids": ["R-BTA-72662", "R-HSA-166208", "R-DME-72662", "R-MMU-72662", "R-BTA-166208", "R-DME-166208", "R-DME-110523", "R-MMU-166208", "R-DDI-166208", "R-DDI-72662", "R-RNO-72662", "R-HSA-72662", "R-RNO-166208"], "pathways": ["R-BTA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-166208:r:mTORC1-mediated signalling", "R-DME-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-MMU-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-BTA-166208:r:mTORC1-mediated signalling", "R-DME-166208:r:mTORC1-mediated signalling", "R-DME-110523:r:TOR signaling pathway", "R-MMU-166208:r:mTORC1-mediated signalling", "R-DDI-166208:r:mTORC1-mediated signalling", "R-DDI-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-RNO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-RNO-166208:r:mTORC1-mediated signalling"], "type": "Family"}, "IPR008608": {"description": "Ectropic viral integration site 2A protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Ectropic_vir_integratn_site_2A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008609": {"description": "Ebola nucleoprotein", "go_ids": ["GO:0019013", "GO:0019074"], "go_terms": ["GO:0019013:viral nucleocapsid:C", "GO:0019074:viral RNA genome packaging:P"], "name": "Ebola_NP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008610": {"description": "Eukaryotic rRNA processing", "go_ids": [], "go_terms": [], "name": "Ebp2", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR008611": {"description": "SPI-2 type 3 secretion system translocon protein SctB-like", "go_ids": [], "go_terms": [], "name": "SctB2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008612": {"description": "Mating pheromone, Euplotes octocarinatus", "go_ids": ["GO:0005186", "GO:0005576", "GO:0007154"], "go_terms": ["GO:0005186:pheromone activity:F", "GO:0005576:extracellular region:C", "GO:0007154:cell communication:P"], "name": "Mating_pheromone_EUPOC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008613": {"description": "Excalibur calcium-binding domain", "go_ids": [], "go_terms": [], "name": "Excalibur_Ca-bd_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008614": {"description": "Acidic fibroblast growth factor intracellular-binding protein", "go_ids": [], "go_terms": [], "name": "FIBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008615": {"description": "FNIP", "go_ids": [], "go_terms": [], "name": "FNIP", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR008617": {"description": "Uncharacterised protein family, YcgJ", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YcgJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008618": {"description": "Protein S10", "go_ids": [], "go_terms": [], "name": "S10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008619": {"description": "Filamentous haemagglutinin repeat", "go_ids": [], "go_terms": [], "name": "Filamentous_hemagglutn_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR008620": {"description": "Nitrogen fixation protein FixH", "go_ids": [], "go_terms": [], "name": "FixH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008621": {"description": "Cbb3-type cytochrome oxidase component", "go_ids": [], "go_terms": [], "name": "Cbb3-typ_cyt_oxidase_comp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008622": {"description": "Flagellar protein FliT", "go_ids": [], "go_terms": [], "name": "FliT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008625": {"description": "G/X antigen", "go_ids": [], "go_terms": [], "name": "GAGE_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008626": {"description": "Mediator complex, subunit Med15, fungi", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med15_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008627": {"description": "GETHR pentapeptide repeat", "go_ids": [], "go_terms": [], "name": "GETHR_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR008628": {"description": "Golgi phosphoprotein 3-like", "go_ids": ["GO:0070273"], "go_terms": ["GO:0070273:phosphatidylinositol-4-phosphate binding:F"], "name": "GPP34-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008629": {"description": "GUN4-like", "go_ids": [], "go_terms": [], "name": "GUN4-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008630": {"description": "Glycosyltransferase 34", "go_ids": ["GO:0016020", "GO:0016757"], "go_terms": ["GO:0016020:membrane:C", "GO:0016757:glycosyltransferase activity:F"], "name": "Glyco_trans_34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008631": {"description": "Glycogen synthase", "go_ids": ["GO:0004373", "GO:0005978"], "go_terms": ["GO:0004373:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity:F", "GO:0005978:glycogen biosynthetic process:P"], "name": "Glycogen_synth", "pathway_ids": ["PWY-5067", "R-CEL-3322077", "R-HSA-3858516", "R-MMU-3322077", "R-HSA-3322077", "R-HSA-3878781", "R-HSA-3814836", "R-HSA-3828062", "R-HSA-3785653", "R-SCE-3322077", "R-BTA-3322077", "R-DME-3322077", "R-RNO-3322077"], "pathways": ["PWY-5067:t:glycogen biosynthesis II (from UDP-D-Glucose)", "R-CEL-3322077:r:Glycogen synthesis", "R-HSA-3858516:r:Glycogen storage disease type 0 (liver GYS2)", "R-MMU-3322077:r:Glycogen synthesis", "R-HSA-3322077:r:Glycogen synthesis", "R-HSA-3878781:r:Glycogen storage disease type IV (GBE1)", "R-HSA-3814836:r:Glycogen storage disease type XV (GYG1)", "R-HSA-3828062:r:Glycogen storage disease type 0 (muscle GYS1)", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-SCE-3322077:r:Glycogen synthesis", "R-BTA-3322077:r:Glycogen synthesis", "R-DME-3322077:r:Glycogen synthesis", "R-RNO-3322077:r:Glycogen synthesis"], "type": "Family"}, "IPR008632": {"description": "Nematode fatty acid retinoid binding", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "Gp-FAR-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008633": {"description": "Gas vesicle protein H", "go_ids": [], "go_terms": [], "name": "GvpH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008634": {"description": "Gas vesicle protein GvpO", "go_ids": ["GO:0031412"], "go_terms": ["GO:0031412:gas vesicle organization:P"], "name": "Gas-vesicle_GvpO", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008635": {"description": "Trimeric autotransporter adhesin YadA-like, stalk domain", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "Coiled_stalk_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008636": {"description": "Hook, C-terminal", "go_ids": ["GO:0008017", "GO:0031122"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0031122:cytoplasmic microtubule organization:P"], "name": "Hook_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008637": {"description": "HR-like lesion-inducer", "go_ids": [], "go_terms": [], "name": "HR_lesion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008638": {"description": "Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain", "go_ids": [], "go_terms": [], "name": "FhaB/CdiA-like_TPS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008639": {"description": "Gas vesicle protein GvpC, halobacteria", "go_ids": ["GO:0031411", "GO:0031412"], "go_terms": ["GO:0031411:gas vesicle:C", "GO:0031412:gas vesicle organization:P"], "name": "Gas-vesicle_GvpC_halobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008640": {"description": "Trimeric autotransporter adhesin YadA-like, head domain", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "Adhesin_Head_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008642": {"description": "Herpesvirus BLRF2", "go_ids": [], "go_terms": [], "name": "Herpes_BLRF2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008644": {"description": "Human herpesvirus U15", "go_ids": [], "go_terms": [], "name": "Herpes_U15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008645": {"description": "Roseolovirus glycoprotein U47", "go_ids": [], "go_terms": [], "name": "Roseolovirus_U47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008647": {"description": "Envelope glycoprotein N domain", "go_ids": [], "go_terms": [], "name": "GN_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008648": {"description": "Herpesvirus ICP27-like", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "ICP27-like", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR008649": {"description": "Herpesvirus UL82/UL83", "go_ids": [], "go_terms": [], "name": "Herpes_UL82/UL83", "pathway_ids": ["R-HSA-9610379", "R-HSA-198933", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR008650": {"description": "Herpesvirus, helicase-primase complex component", "go_ids": [], "go_terms": [], "name": "Helicase-primas_cplx_Herpesvir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008651": {"description": "Uncharacterised protein family HicB", "go_ids": [], "go_terms": [], "name": "Uncharacterised_HicB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008652": {"description": "Adenovirus type 2, E3A glycoprotein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Adenovirus_Type-2_E3A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008653": {"description": "Immediate early response", "go_ids": [], "go_terms": [], "name": "IER", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008655": {"description": "Helicobacter pylori IceA2", "go_ids": [], "go_terms": [], "name": "IceA2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008656": {"description": "Inositol-tetrakisphosphate 1-kinase", "go_ids": ["GO:0052725", "GO:0052726", "GO:0000287", "GO:0005524", "GO:0032957", "GO:0047325"], "go_terms": ["GO:0052725:inositol-1,3,4-trisphosphate 6-kinase activity:F", "GO:0052726:inositol-1,3,4-trisphosphate 5-kinase activity:F", "GO:0000287:magnesium ion binding:F", "GO:0005524:ATP binding:F", "GO:0032957:inositol trisphosphate metabolic process:P", "GO:0047325:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity:F"], "name": "Inositol_tetrakis-P_1-kinase", "pathway_ids": ["PWY-6366", "PWY-6554", "PWY-6362", "PWY-6372", "PWY-4661", "PWY-6365", "R-MMU-983231", "R-GGA-983231", "R-BTA-1855204", "R-HSA-1855167", "R-MMU-1855167", "R-HSA-1855204", "R-BTA-1855167", "R-HSA-983231", "R-GGA-1855167", "R-MMU-1855204", "R-GGA-1855204", "R-BTA-983231"], "pathways": ["PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6554:t:1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)", "PWY-6362:t:1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)", "PWY-6372:t:1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)", "PWY-4661:t:1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-GGA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Family"}, "IPR008657": {"description": "Jumping translocation breakpoint", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "JTB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008658": {"description": "Kinesin-associated protein 3", "go_ids": ["GO:0005871", "GO:0019894"], "go_terms": ["GO:0005871:kinesin complex:C", "GO:0019894:kinesin binding:F"], "name": "KAP3", "pathway_ids": ["R-HSA-2132295", "R-HSA-5620924", "R-HSA-6811434", "R-HSA-983189", "R-HSA-1445148", "R-MMU-2132295", "R-MMU-983189", "R-MMU-5620924", "R-MMU-6811434"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-5620924:r:Intraflagellar transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-983189:r:Kinesins", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983189:r:Kinesins", "R-MMU-5620924:r:Intraflagellar transport", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR008659": {"description": "Yeast cell wall synthesis Kre9/Knh1, C-terminal", "go_ids": ["GO:0042546", "GO:0006078"], "go_terms": ["GO:0042546:cell wall biogenesis:P", "GO:0006078:(1->6)-beta-D-glucan biosynthetic process:P"], "name": "Kre9/Knh1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008660": {"description": "Fibroin light chain", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "L-fibroin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008661": {"description": "L6 membrane", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "L6_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008662": {"description": "Torsin-1A-interacting protein 1/2", "go_ids": ["GO:0001671"], "go_terms": ["GO:0001671:ATPase activator activity:F"], "name": "TOIP1/2", "pathway_ids": ["R-HSA-9013405", "R-RNO-9035034", "R-MMU-9035034", "R-HSA-9035034", "R-BTA-9035034"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-BTA-9035034:r:RHOF GTPase cycle"], "type": "Family"}, "IPR008663": {"description": "Leukocyte cell-derived chemotaxin 2", "go_ids": [], "go_terms": [], "name": "LECT2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008664": {"description": "LISCH7", "go_ids": [], "go_terms": [], "name": "LISCH7", "pathway_ids": ["R-HSA-8964038", "R-HSA-8964046"], "pathways": ["R-HSA-8964038:r:LDL clearance", "R-HSA-8964046:r:VLDL clearance"], "type": "Domain"}, "IPR008665": {"description": "LRV FeS4 cluster", "go_ids": [], "go_terms": [], "name": "LRV_FeS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008668": {"description": "Virion infectivity factor, Lentivirus", "go_ids": ["GO:0019058"], "go_terms": ["GO:0019058:viral life cycle:P"], "name": "Vir_infectivity_fact_Lentivir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008669": {"description": "LSM-interacting domain", "go_ids": [], "go_terms": [], "name": "LSM_interact", "pathway_ids": ["R-SPO-72163", "R-SPO-9770562", "R-SPO-72203"], "pathways": ["R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Domain"}, "IPR008670": {"description": "Long-chain-fatty-acyl-CoA reductase LuxC", "go_ids": ["GO:0008218", "GO:0003995"], "go_terms": ["GO:0008218:bioluminescence:P", "GO:0003995:acyl-CoA dehydrogenase activity:F"], "name": "CoA_reduct_LuxC", "pathway_ids": ["PWY-7723"], "pathways": ["PWY-7723:t:bacterial bioluminescence"], "type": "Family"}, "IPR008672": {"description": "Spindle assembly checkpoint component Mad1", "go_ids": ["GO:0007094"], "go_terms": ["GO:0007094:mitotic spindle assembly checkpoint signaling:P"], "name": "Mad1", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-MMU-141444", "R-HSA-2467813", "R-HSA-68877", "R-MMU-2467813", "R-HSA-141444", "R-HSA-5663220", "R-MMU-68877", "R-MMU-9648025", "R-HSA-9648025", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR008673": {"description": "Microfibril-associated glycoprotein", "go_ids": [], "go_terms": [], "name": "MAGP", "pathway_ids": ["R-HSA-1566948", "R-HSA-2129379", "R-MMU-1566948", "R-MMU-2129379"], "pathways": ["R-HSA-1566948:r:Elastic fibre formation", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-MMU-1566948:r:Elastic fibre formation", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Family"}, "IPR008674": {"description": "Chromosomal protein MC1", "go_ids": ["GO:0042262"], "go_terms": ["GO:0042262:DNA protection:P"], "name": "MC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008675": {"description": "Mating factor alpha precursor, N-terminal", "go_ids": ["GO:0005576", "GO:0007618"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0007618:mating:P"], "name": "Mating_factor_alpha_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008676": {"description": "MRG", "go_ids": ["GO:0005634", "GO:0006325", "GO:0006355"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006325:chromatin organization:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "MRG", "pathway_ids": ["R-MMU-3214847", "R-HSA-3214847", "R-DME-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR008677": {"description": "MRVI1", "go_ids": [], "go_terms": [], "name": "MRVI1", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-HSA-418457", "R-DRE-6798695", "R-MMU-418457"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-418457:r:cGMP effects", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-418457:r:cGMP effects"], "type": "Family"}, "IPR008680": {"description": "Mastadenovirus early E4 13kDa", "go_ids": [], "go_terms": [], "name": "M_adenovirusE4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008681": {"description": "Negative regulator of genetic competence, MecA", "go_ids": [], "go_terms": [], "name": "Neg-reg_MecA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008685": {"description": "Centromere protein Mis12", "go_ids": ["GO:0000775", "GO:0005634", "GO:0000278"], "go_terms": ["GO:0000775:chromosome, centromeric region:C", "GO:0005634:nucleus:C", "GO:0000278:mitotic cell cycle:P"], "name": "Centromere_Mis12", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-MMU-141444", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-BTA-5663220", "R-MMU-68877", "R-HSA-9648025", "R-RNO-5663220", "R-GGA-2500257", "R-GGA-141444", "R-BTA-2467813", "R-HSA-68877", "R-GGA-9648025", "R-BTA-2500257", "R-GGA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-GGA-2467813", "R-BTA-9648025", "R-BTA-141444", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR008686": {"description": "RNA-dependent RNA polymerase, mitoviral", "go_ids": [], "go_terms": [], "name": "RNA_pol_mitovir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008687": {"description": "Bacterial mobilisation", "go_ids": [], "go_terms": [], "name": "MobC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008688": {"description": "ATP synthase, F0 complex, subunit B/MI25", "go_ids": ["GO:0015078", "GO:0015986"], "go_terms": ["GO:0015078:proton transmembrane transporter activity:F", "GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_Bsub_B/MI25", "pathway_ids": ["R-BTA-8949613", "R-CEL-163210", "R-MMU-163210", "R-DME-8949613", "R-BTA-163210", "R-CEL-8949613", "R-RNO-163210", "R-DME-163210", "R-RNO-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-BTA-8949613:r:Cristae formation", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-8949613:r:Cristae formation", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR008689": {"description": "ATP synthase, F0 complex, subunit D, mitochondrial", "go_ids": ["GO:0015078", "GO:0015986"], "go_terms": ["GO:0015078:proton transmembrane transporter activity:F", "GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_F0_dsu_mt", "pathway_ids": ["R-MMU-9837999", "R-BTA-8949613", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-DME-9837999", "R-MMU-163210", "R-DME-8949613", "R-BTA-163210", "R-HSA-9837999", "R-RNO-163210", "R-DME-163210", "R-RNO-8949613", "R-RNO-9837999", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-8949613:r:Cristae formation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-8949613:r:Cristae formation", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR008690": {"description": "Tetrahydromethanopterin S-methyltransferase subunit B", "go_ids": ["GO:0015948", "GO:0016020", "GO:0030269"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0016020:membrane:C", "GO:0030269:tetrahydromethanopterin S-methyltransferase activity:F"], "name": "MtrB_MeTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008691": {"description": "19kDa lipoprotein antigen", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "LpqH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008692": {"description": "Haemagglutinin, Mycoplasma", "go_ids": [], "go_terms": [], "name": "Hemogglutn_Mycoplasma", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008693": {"description": "Transport accessory protein MmpS", "go_ids": [], "go_terms": [], "name": "MmpS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008698": {"description": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, NDUB7", "go_ids": ["GO:0005739"], "go_terms": ["GO:0005739:mitochondrion:C"], "name": "NDUB7", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR008699": {"description": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8", "go_ids": ["GO:0005739"], "go_terms": ["GO:0005739:mitochondrion:C"], "name": "NDUFB8", "pathway_ids": ["R-HSA-611105", "R-HSA-1268020", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-1268020", "R-MMU-1268020", "R-MMU-611105", "R-BTA-6799198", "R-BTA-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-1268020:r:Mitochondrial protein import", "R-MMU-1268020:r:Mitochondrial protein import", "R-MMU-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR008700": {"description": "RIN4, pathogenic type III effector avirulence factor Avr cleavage site", "go_ids": [], "go_terms": [], "name": "TypeIII_avirulence_cleave", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008701": {"description": "Necrosis inducing protein", "go_ids": [], "go_terms": [], "name": "NPP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008702": {"description": "Nucleopolyhedrovirus P10", "go_ids": ["GO:0039679"], "go_terms": ["GO:0039679:viral occlusion body:C"], "name": "NPV_P10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008703": {"description": "Na(+)-translocating NADH-quinone reductase subunit A", "go_ids": ["GO:0006814", "GO:0016655"], "go_terms": ["GO:0006814:sodium ion transport:P", "GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F"], "name": "NqrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008704": {"description": "Zinc-binding loop region of homing endonuclease", "go_ids": [], "go_terms": [], "name": "Endonuclease_Zinc-binding_loop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008705": {"description": "Nanos/Xcat2", "go_ids": ["GO:0003723", "GO:0008270"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0008270:zinc ion binding:F"], "name": "Nanos/Xcar2", "pathway_ids": ["R-HSA-9827857"], "pathways": ["R-HSA-9827857:r:Specification of primordial germ cells"], "type": "Family"}, "IPR008706": {"description": "Nanovirus component 8", "go_ids": [], "go_terms": [], "name": "Nanovirus_C8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008707": {"description": "PilY1, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "B-propeller_PilY1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008708": {"description": "TspB virulence factor", "go_ids": [], "go_terms": [], "name": "Neisseria_TspB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008709": {"description": "Neurochondrin", "go_ids": [], "go_terms": [], "name": "Neurochondrin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008710": {"description": "Nicastrin", "go_ids": ["GO:0016020", "GO:0016485"], "go_terms": ["GO:0016020:membrane:C", "GO:0016485:protein processing:P"], "name": "Nicastrin", "pathway_ids": ["R-MMU-9839383", "R-HSA-6798695", "R-HSA-2122948", "R-MMU-3928665", "R-RNO-9017802", "R-CEL-6798695", "R-HSA-977225", "R-HSA-1251985", "R-RNO-193692", "R-CEL-1251985", "R-HSA-9017802", "R-MMU-193692", "R-HSA-2979096", "R-HSA-9013700", "R-MMU-9013507", "R-RNO-3928665", "R-RNO-205043", "R-DME-3928665", "R-HSA-9013507", "R-DME-1251985", "R-MMU-205043", "R-RNO-1251985", "R-HSA-1474228", "R-DDI-6798695", "R-DME-6798695", "R-HSA-205043", "R-HSA-2894862", "R-RNO-9839383", "R-RNO-9013507", "R-HSA-9839383", "R-MMU-9017802", "R-CEL-3928665", "R-MMU-1251985", "R-HSA-3928665", "R-MMU-6798695", "R-HSA-2644606", "R-HSA-193692", "R-RNO-6798695"], "pathways": ["R-MMU-9839383:r:TGFBR3 PTM regulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR008711": {"description": "Recombinase NinB", "go_ids": [], "go_terms": [], "name": "Recombinase_NinB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008712": {"description": "NinF", "go_ids": [], "go_terms": [], "name": "NinF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008713": {"description": "Bacteriophage lambda NinG", "go_ids": [], "go_terms": [], "name": "Phage_lambda_NinG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008715": {"description": "SAM-dependent methyltransferase, NodS-like", "go_ids": ["GO:0008757", "GO:0009312"], "go_terms": ["GO:0008757:S-adenosylmethionine-dependent methyltransferase activity:F", "GO:0009312:oligosaccharide biosynthetic process:P"], "name": "SAM-MeTfrase_NodS-like", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR008716": {"description": "Nodulation protein Z", "go_ids": ["GO:0009312", "GO:0016758"], "go_terms": ["GO:0009312:oligosaccharide biosynthetic process:P", "GO:0016758:hexosyltransferase activity:F"], "name": "NodZ", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR008717": {"description": "Noggin", "go_ids": ["GO:0045596", "GO:0030514"], "go_terms": ["GO:0045596:negative regulation of cell differentiation:P", "GO:0030514:negative regulation of BMP signaling pathway:P"], "name": "Noggin", "pathway_ids": ["R-MMU-201451", "R-HSA-201451", "R-DRE-201451", "R-HSA-9793380"], "pathways": ["R-MMU-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-DRE-201451:r:Signaling by BMP", "R-HSA-9793380:r:Formation of paraxial mesoderm"], "type": "Family"}, "IPR008718": {"description": "NolX", "go_ids": [], "go_terms": [], "name": "NolX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008719": {"description": "Nitrous oxide reductase accessory protein NosL", "go_ids": [], "go_terms": [], "name": "N2O_reductase_NosL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008720": {"description": "Viral hemorrhagic septicemia virus non-virion", "go_ids": [], "go_terms": [], "name": "Novirhabdo_Nv", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008721": {"description": "ORC6, first cyclin-like domain", "go_ids": ["GO:0003677", "GO:0005664", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005664:nuclear origin of replication recognition complex:C", "GO:0006260:DNA replication:P"], "name": "ORC6_cyclin_first", "pathway_ids": ["R-DDI-68689", "R-SPO-176187", "R-HSA-68949", "R-SPO-68616", "R-BTA-68616", "R-DME-68949", "R-MMU-68962", "R-HSA-113507", "R-BTA-68949", "R-HSA-68867", "R-MMU-68949", "R-HSA-68689", "R-HSA-176187", "R-BTA-68962", "R-DME-68616", "R-BTA-176187", "R-HSA-68616", "R-DME-68689", "R-DME-68962", "R-DDI-68962", "R-SPO-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949", "R-BTA-68689", "R-DME-176187", "R-DDI-68616"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68949:r:Orc1 removal from chromatin", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication"], "type": "Domain"}, "IPR008722": {"description": "Outer membrane porin F, N-terminal", "go_ids": [], "go_terms": [], "name": "OprF_membrane_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008723": {"description": "RNA-dependent RNA polymerase, orbiviral", "go_ids": ["GO:0003723", "GO:0003968", "GO:0006351"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "RNA_pol_orbivir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008724": {"description": "Protein C1, Orthopoxvirus", "go_ids": [], "go_terms": [], "name": "Orthopox_C1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008725": {"description": "Orthopoxvirus F7", "go_ids": [], "go_terms": [], "name": "Orthopox_F7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008726": {"description": "Poxvirus F8", "go_ids": [], "go_terms": [], "name": "Poxvirus_F8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008727": {"description": "PAAR motif", "go_ids": [], "go_terms": [], "name": "PAAR_motif", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR008728": {"description": "Elongator complex protein 4", "go_ids": ["GO:0033588", "GO:0002098"], "go_terms": ["GO:0033588:elongator holoenzyme complex:C", "GO:0002098:tRNA wobble uridine modification:P"], "name": "Elongator_complex_protein_4", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR008729": {"description": "Phenolic acid decarboxylase", "go_ids": ["GO:0016831"], "go_terms": ["GO:0016831:carboxy-lyase activity:F"], "name": "PA_de_COase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008730": {"description": "Pheromone biosynthesis activating neuropeptide", "go_ids": ["GO:0005184", "GO:0007218", "GO:0042811"], "go_terms": ["GO:0005184:neuropeptide hormone activity:F", "GO:0007218:neuropeptide signaling pathway:P", "GO:0042811:pheromone biosynthetic process:P"], "name": "PBAN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008731": {"description": "Phosphotransferase system, enzyme I N-terminal", "go_ids": ["GO:0009401"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PTS_EIN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008732": {"description": "Protein Pet122", "go_ids": ["GO:0070131", "GO:0003743", "GO:0005743"], "go_terms": ["GO:0070131:positive regulation of mitochondrial translation:P", "GO:0003743:translation initiation factor activity:F", "GO:0005743:mitochondrial inner membrane:C"], "name": "Pet122", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008733": {"description": "Peroxisomal biogenesis factor 11", "go_ids": ["GO:0016559", "GO:0005778"], "go_terms": ["GO:0016559:peroxisome fission:P", "GO:0005778:peroxisomal membrane:C"], "name": "PEX11", "pathway_ids": ["R-HSA-1989781", "R-SCE-9603798", "R-DDI-9603798", "R-MMU-9603798", "R-HSA-9603798", "R-BTA-9603798", "R-HSA-9841922", "R-SPO-9603798"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SPO-9603798:r:Class I peroxisomal membrane protein import"], "type": "Family"}, "IPR008734": {"description": "Phosphorylase kinase alpha/beta subunit", "go_ids": ["GO:0005516", "GO:0005977"], "go_terms": ["GO:0005516:calmodulin binding:F", "GO:0005977:glycogen metabolic process:P"], "name": "PHK_A/B_su", "pathway_ids": ["R-MMU-70221", "R-CEL-70221", "R-HSA-70221", "R-RNO-70221", "R-DME-70221"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-CEL-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-DME-70221:r:Glycogen breakdown (glycogenolysis)"], "type": "Family"}, "IPR008735": {"description": "Beta-microseminoprotein", "go_ids": [], "go_terms": [], "name": "PSP94", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008737": {"description": "Putative aspartic peptidase, DUF1758", "go_ids": [], "go_terms": [], "name": "DUF1758", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008738": {"description": "Peptidase C27, rubella virus endopeptidase", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "Peptidase_C27", "pathway_ids": ["PWY-7342", "PWY-7185", "PWY-7198", "PWY-5381", "PWY-6545", "PWY-2681", "PWY-5316", "PWY-7184", "PWY-7564", "PWY-7210", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-5381:t:NAD salvage (plants)", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Domain"}, "IPR008739": {"description": "Peptidase C28, foot-and-mouth virus L-proteinase", "go_ids": ["GO:0004197", "GO:0016032", "GO:0019082"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0016032:viral process:P", "GO:0019082:viral protein processing:P"], "name": "Peptidase_C28", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR008740": {"description": "Peptidase C30, coronavirus", "go_ids": ["GO:0008233", "GO:0019082"], "go_terms": ["GO:0008233:peptidase activity:F", "GO:0019082:viral protein processing:P"], "name": "Peptidase_C30_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR008741": {"description": "Arterivirus papain-like cysteine protease alpha (PCPalpha) domain", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "AV_PCPalpha", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR008743": {"description": "Arterivirus Nsp2, peptidase C33", "go_ids": ["GO:0016032", "GO:0019082"], "go_terms": ["GO:0016032:viral process:P", "GO:0019082:viral protein processing:P"], "name": "Arterivirus_Nsp2_C33", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR008744": {"description": "RNA-directed RNA polymerase, apple chlorotic leaf spot virus", "go_ids": ["GO:0003723", "GO:0003968", "GO:0005524", "GO:0019079"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0005524:ATP binding:F", "GO:0019079:viral genome replication:P"], "name": "RNA-dir_pol_ACLSV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008745": {"description": "Domain of unknown function DUF1717", "go_ids": [], "go_terms": [], "name": "DUF1717", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008746": {"description": "Peptidase C36, beet necrotic yellow vein furovirus-type papain-like endopeptidase", "go_ids": [], "go_terms": [], "name": "Peptidase_C36", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008748": {"description": "Hepatitis E virus, cysteine peptidase", "go_ids": ["GO:0019082"], "go_terms": ["GO:0019082:viral protein processing:P"], "name": "Hepatitis-E_Cys-pept", "pathway_ids": ["PWY-7045", "PWY-5381", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-7706", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-5316", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-7529", "PWY-8076", "PWY-5479", "PWY-6322", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-7342", "PWY-7904", "PWY-6736", "PWY-6998", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-7888", "PWY-5773", "PWY-7155", "PWY-7719", "PWY-7076", "PWY-7737", "PWY-8106", "PWY-6682", "PWY-8104", "PWY-7419", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-6749", "PWY-7668", "PWY-8179", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-7769", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-7127", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6626", "PWY-6286", "PWY-6581", "PWY-4202", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7250", "PWY-7742", "PWY-2681", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-8117", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR008749": {"description": "Peptidase C42, beet yellows virus-type papain-like endopeptidase C42", "go_ids": [], "go_terms": [], "name": "Peptidase_C42", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008750": {"description": "Staphopain peptidase C47", "go_ids": ["GO:0006508", "GO:0008234"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008234:cysteine-type peptidase activity:F"], "name": "Peptidase_C47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008751": {"description": "Peptidase C53, pestivirus Npro", "go_ids": ["GO:0016032", "GO:0019082"], "go_terms": ["GO:0016032:viral process:P", "GO:0019082:viral protein processing:P"], "name": "Peptidase_C53", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR008752": {"description": "Peptidase M11, gametolysin", "go_ids": [], "go_terms": [], "name": "Peptidase_M11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008753": {"description": "Peptidase M13, N-terminal domain", "go_ids": ["GO:0006508"], "go_terms": ["GO:0006508:proteolysis:P"], "name": "Peptidase_M13_N", "pathway_ids": ["R-HSA-5578768", "R-HSA-6798695", "R-MMU-5578768", "R-RNO-375276", "R-HSA-375276", "R-DME-6798695", "R-HSA-9927432", "R-RNO-5578768", "R-MMU-6798695", "R-DME-2022377", "R-RNO-2022377", "R-DME-5578768", "R-MMU-375276", "R-HSA-2022377", "R-RNO-6798695", "R-BTA-375276", "R-MMU-2022377"], "pathways": ["R-HSA-5578768:r:Physiological factors", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5578768:r:Physiological factors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-RNO-5578768:r:Physiological factors", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-5578768:r:Physiological factors", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Domain"}, "IPR008754": {"description": "Peptidase M43, pregnancy-associated plasma-A", "go_ids": [], "go_terms": [], "name": "Peptidase_M43", "pathway_ids": ["PWY-8119", "R-MMU-381426", "R-HSA-381426"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR008756": {"description": "Peptidase M56", "go_ids": [], "go_terms": [], "name": "Peptidase_M56", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008757": {"description": "Peptidase M6-like, domain", "go_ids": ["GO:0006508", "GO:0008233"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008233:peptidase activity:F"], "name": "Peptidase_M6-like_domain", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR008758": {"description": "Peptidase S28", "go_ids": ["GO:0006508", "GO:0070008"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0070008:serine-type exopeptidase activity:F"], "name": "Peptidase_S28", "pathway_ids": ["R-MMU-140837", "R-HSA-6798695", "R-MMU-6798695", "R-HSA-140837", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR008760": {"description": "Equine arteritis virus-type peptidase S32", "go_ids": ["GO:0004252", "GO:0016032", "GO:0019082"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0016032:viral process:P", "GO:0019082:viral protein processing:P"], "name": "EAV_peptidase_S32", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR008761": {"description": "Peptidase S37, tripeptidyl aminopeptidase", "go_ids": [], "go_terms": [], "name": "Peptidase_S37", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008763": {"description": "Peptidase S55, SpoIVB", "go_ids": [], "go_terms": [], "name": "Peptidase_S55", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008764": {"description": "Peptidase U57, YabG", "go_ids": [], "go_terms": [], "name": "Peptidase_U57", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008765": {"description": "Bacteriophage T4, Frd3", "go_ids": [], "go_terms": [], "name": "Phage_T4_Frd3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008766": {"description": "Replication gene A protein-like", "go_ids": ["GO:0006260"], "go_terms": ["GO:0006260:DNA replication:P"], "name": "Replication_gene_A-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008767": {"description": "Bacteriophage SPP1, head-tail adaptor", "go_ids": [], "go_terms": [], "name": "Phage_SPP1_head-tail_adaptor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008768": {"description": "Capsid assembly scaffolding protein-like", "go_ids": ["GO:0019069"], "go_terms": ["GO:0019069:viral capsid assembly:P"], "name": "Gp9-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008769": {"description": "Poly granule associated", "go_ids": [], "go_terms": [], "name": "PhaF_PhaI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008770": {"description": "DNA terminal protein Gp3", "go_ids": ["GO:0006260", "GO:0006269"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0006269:DNA replication, synthesis of primer:P"], "name": "DNA_terminal_Gp3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008771": {"description": "Phi-29-like late genes activator", "go_ids": ["GO:0003899", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "Phi-29_GP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008772": {"description": "Bacterial phosphonate metabolism, PhnH", "go_ids": ["GO:0019634"], "go_terms": ["GO:0019634:organic phosphonate metabolic process:P"], "name": "Phosphonate_metab_PhnH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008773": {"description": "Phosphonate metabolism protein PhnI", "go_ids": ["GO:0019634"], "go_terms": ["GO:0019634:organic phosphonate metabolic process:P"], "name": "PhnI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008775": {"description": "Phytanoyl-CoA dioxygenase-like", "go_ids": [], "go_terms": [], "name": "Phytyl_CoA_dOase-like", "pathway_ids": ["R-BTA-9033241", "R-BTA-389599", "R-CEL-389599", "R-RNO-9033241", "R-HSA-389599", "R-RNO-389599", "R-SCE-9033241", "R-HSA-9033500", "R-MMU-9033241", "R-SCE-389599", "R-HSA-9033241", "R-MMU-389599"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-BTA-389599:r:Alpha-oxidation of phytanate", "R-CEL-389599:r:Alpha-oxidation of phytanate", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-SCE-9033241:r:Peroxisomal protein import", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-MMU-9033241:r:Peroxisomal protein import", "R-SCE-389599:r:Alpha-oxidation of phytanate", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-389599:r:Alpha-oxidation of phytanate"], "type": "Family"}, "IPR008776": {"description": "Phytoreovirus Pns9Pns10", "go_ids": [], "go_terms": [], "name": "Phyto_Pns9_10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008777": {"description": "Phytoreovirus Pns1011", "go_ids": [], "go_terms": [], "name": "Phytoreo_Pns", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008778": {"description": "Pirin, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Pirin_C_dom", "pathway_ids": ["R-RNO-8935690", "R-MMU-8935690", "R-HSA-8935690"], "pathways": ["R-RNO-8935690:r:Digestion", "R-MMU-8935690:r:Digestion", "R-HSA-8935690:r:Digestion"], "type": "Domain"}, "IPR008779": {"description": "Histidine-rich protein PFHRP", "go_ids": [], "go_terms": [], "name": "Plasmodium_HRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008780": {"description": "Plasmodium vivax Vir", "go_ids": [], "go_terms": [], "name": "Plasmodium_Vir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008781": {"description": "Pneumovirinae attachment membrane glycoprotein G", "go_ids": [], "go_terms": [], "name": "Pneumo_att_G", "pathway_ids": [], "pathways": [], "type": "Family"}, 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{"description": "Poxvirus serine/threonine kinase", "go_ids": ["GO:0004672", "GO:0005524"], "go_terms": ["GO:0004672:protein kinase activity:F", "GO:0005524:ATP binding:F"], "name": "Poxvirus_ser/thr_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008791": {"description": "Orthopoxvirus interleukin 18 binding", "go_ids": [], "go_terms": [], "name": "Orthopox_IL18-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008792": {"description": "Coenzyme PQQ synthesis protein D", "go_ids": [], "go_terms": [], "name": "PQQD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008794": {"description": "Proline racemase family", "go_ids": [], "go_terms": [], "name": "Pro_racemase_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008795": {"description": "Prominin", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Prominin", "pathway_ids": ["R-HSA-9925563"], "pathways": ["R-HSA-9925563:r:Developmental Lineage of 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phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR008853": {"description": "TMEM9/TMEM9B", "go_ids": ["GO:0005765"], "go_terms": ["GO:0005765:lysosomal membrane:C"], "name": "TMEM9/TMEM9B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008854": {"description": "TPMT family", "go_ids": 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{"description": "Relaxosome protein TraY", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "TraY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008878": {"description": "Transposase IS66, Orf2", "go_ids": [], "go_terms": [], "name": "Transposase_IS66_Orf2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008879": {"description": "Coat protein, trichovirus/vitivirus", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Coat_protein_tricho/vitivirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008880": {"description": "Trigger factor, C-terminal", "go_ids": ["GO:0006457", "GO:0015031"], "go_terms": ["GO:0006457:protein folding:P", "GO:0015031:protein transport:P"], "name": "Trigger_fac_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008881": {"description": "Trigger factor, ribosome-binding, bacterial", "go_ids": ["GO:0006457", "GO:0015031"], "go_terms": ["GO:0006457:protein 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"go_ids": [], "go_terms": [], "name": "QdtA_cupin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008896": {"description": "Protein TIC214", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TIC214", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008897": {"description": "Yeast trans-acting factor", "go_ids": ["GO:0030541"], "go_terms": ["GO:0030541:plasmid partitioning:P"], "name": "Rep_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008898": {"description": "YopD-like", "go_ids": [], "go_terms": [], "name": "YopD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008899": {"description": "Zinc finger, piccolo-type", "go_ids": ["GO:0045202", "GO:0046872"], "go_terms": ["GO:0045202:synapse:C", "GO:0046872:metal ion binding:F"], "name": "Znf_piccolo", "pathway_ids": ["R-HSA-9662360"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea"], "type": "Domain"}, "IPR008900": {"description": "Zona occludens toxin, N-terminal", "go_ids": [], "go_terms": [], "name": "Zot_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008901": {"description": "Alkaline ceramidase", "go_ids": ["GO:0006672", "GO:0016020"], "go_terms": ["GO:0006672:ceramide metabolic process:P", "GO:0016020:membrane:C"], "name": "ACER", "pathway_ids": ["PWY-7403", "PWY-8229", "PWY-7571", "PWY-7850", "PWY-7430", "PWY-6483", "PWY-8418", "PWY-7496", "PWY-8453", "PWY-8432", "PWY-8293", "PWY-7119", "PWY-5846", "PWY-7018", "PWY-5497", "PWY-8431", "PWY-1822", "PWY-7821", "PWY-6409", "PWY-6899", "PWY-7652", "PWY-5784", "PWY-7771", "PWY-8402", "R-SCE-9845614", "R-DRE-9845614", "R-MMU-9845614", "R-DME-9845614", "R-CEL-9845614", "R-DDI-9845614", "R-HSA-9845614"], "pathways": ["PWY-7403:t:tetramethylpyrazine degradation", "PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7850:t:taurine biosynthesis II", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-6483:t:ceramide degradation (generic)", "PWY-8418:t:S-benzyl-L-cysteine degradation", "PWY-7496:t:linuron degradation", "PWY-8453:t:D-glutamate degradation", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-8293:t:alazopeptin biosynthesis", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-5846:t:colchicine biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8431:t:L-mimosine degradation", "PWY-1822:t:indole-3-acetate activation I", "PWY-7821:t:tunicamycin biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-6899:t:base-degraded thiamine salvage", "PWY-7652:t:echinocandin B degradation", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-7771:t:butachlor degradation", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation", "R-SCE-9845614:r:Sphingolipid catabolism", "R-DRE-9845614:r:Sphingolipid catabolism", "R-MMU-9845614:r:Sphingolipid catabolism", "R-DME-9845614:r:Sphingolipid catabolism", "R-CEL-9845614:r:Sphingolipid catabolism", "R-DDI-9845614:r:Sphingolipid catabolism", "R-HSA-9845614:r:Sphingolipid catabolism"], "type": "Family"}, "IPR008902": {"description": "Alpha-L-rhamnosidase, concanavalin-like domain", "go_ids": [], "go_terms": [], "name": "Rhamnosid_concanavalin", "pathway_ids": ["PWY-7134"], "pathways": ["PWY-7134:t:rutin degradation (plants)"], "type": "Domain"}, "IPR008903": {"description": "Hemagglutinin component HA-17", "go_ids": [], "go_terms": [], "name": "HA-17_C_botulinum", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008905": {"description": "Eukaryotic translation initiation factor 3 subunit C, N-terminal domain", "go_ids": ["GO:0003743", "GO:0005852", "GO:0006413", "GO:0031369"], "go_terms": ["GO:0003743:translation initiation factor activity:F", "GO:0005852:eukaryotic translation initiation factor 3 complex:C", "GO:0006413:translational initiation:P", "GO:0031369:translation initiation factor binding:F"], "name": "EIF3C_N_dom", "pathway_ids": ["R-CEL-72689", "R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-CEL-72695", "R-XTR-72702", "R-RNO-72689", "R-HSA-156827", "R-MMU-72649", "R-RNO-72695", "R-BTA-72689", "R-HSA-72695", "R-MMU-72706", "R-SPO-72689", "R-BTA-72695", "R-SCE-72695", "R-SCE-72702", "R-XTR-72695", "R-MMU-72695", "R-DRE-156827", "R-DME-72695", "R-SCE-156827", "R-BTA-156827", "R-MMU-72702", "R-RNO-156827", "R-DRE-72695", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-XTR-156827", "R-DME-72689", "R-BTA-72702", "R-RNO-72702", "R-HSA-72706", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-CEL-156827", "R-RNO-72649", "R-DRE-72649", "R-SCE-72649", "R-DRE-72702", "R-DRE-72689", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-BTA-72649", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": ["R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72649:r:Translation initiation complex formation", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Domain"}, "IPR008906": {"description": "HAT, C-terminal dimerisation domain", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "HATC_C_dom", "pathway_ids": ["R-HSA-4551638"], "pathways": ["R-HSA-4551638:r:SUMOylation of chromatin organization proteins"], "type": "Domain"}, "IPR008907": {"description": "Tubulin polymerization-promoting protein", "go_ids": ["GO:0046785", "GO:0015631"], "go_terms": ["GO:0046785:microtubule polymerization:P", "GO:0015631:tubulin binding:F"], "name": "TPP/p25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008908": {"description": "Sarcoglycan alpha/epsilon", "go_ids": ["GO:0016012"], "go_terms": ["GO:0016012:sarcoglycan complex:C"], "name": "Sarcoglycan_alpha/epsilon", "pathway_ids": ["R-HSA-9913351", "R-MMU-9913351", "R-RNO-9913351"], "pathways": ["R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Family"}, "IPR008909": {"description": "DALR anticodon binding", "go_ids": ["GO:0004814", "GO:0005524", "GO:0006420"], "go_terms": ["GO:0004814:arginine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0006420:arginyl-tRNA aminoacylation:P"], "name": "DALR_anticod-bd", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-HSA-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-HSA-379716", "R-RNO-9856649", "R-DME-9856649"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Domain"}, "IPR008910": {"description": "Mechanosensitive ion channel, conserved TM helix", "go_ids": [], "go_terms": [], "name": "MSC_TM_helix", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR008911": {"description": "Short scorpion toxin, potassium channel inhibitor alpha-KTx 8/9", "go_ids": ["GO:0005576", "GO:0008200"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0008200:ion channel inhibitor activity:F"], "name": "Toxin_alpha-KTx_8/9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008912": {"description": "Regulatory protein ViaA-like, vWA domain", "go_ids": [], "go_terms": [], "name": "ViaA-like_vWA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR008913": {"description": "Zinc finger, CHY-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_CHY", "pathway_ids": ["R-HSA-110320", "R-MMU-110320", "R-HSA-983168", "R-HSA-9954709", "R-MMU-983168", "R-MMU-9954709"], "pathways": ["R-HSA-110320:r:Translesion Synthesis by POLH", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR008914": {"description": "Phosphatidylethanolamine-binding protein", "go_ids": [], "go_terms": [], "name": "PEBP", "pathway_ids": ["R-DME-5674135", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-RNO-5389840", "R-CEL-5675221", "R-HSA-6802952", "R-MMU-9937383", "R-HSA-5419276", "R-HSA-9937383", "R-RNO-5675221", "R-CEL-5674135", "R-BTA-9937383", "R-MMU-5389840", "R-CFA-5675221", "R-DME-5675221", "R-BTA-5675221", "R-BTA-5674135", "R-BTA-5389840", "R-RNO-5419276", "R-HSA-6802946", "R-HSA-9649948", "R-CFA-5674135", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-RNO-5674135", "R-RNO-9937383", "R-HSA-5389840", "R-HSA-6802955", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-DME-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-CFA-5675221:r:Negative regulation of MAPK pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CFA-5674135:r:MAP2K and MAPK activation", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR008915": {"description": "Peptidase M50", "go_ids": ["GO:0006508"], "go_terms": ["GO:0006508:proteolysis:P"], "name": "Peptidase_M50", "pathway_ids": ["PWY-8119", "R-HSA-1655829", "R-BTA-381033", "R-MMU-8874177", "R-HSA-8963889", "R-HSA-8874177", "R-BTA-8874211", "R-MMU-8874211", "R-MMU-381033", "R-HSA-8874211", "R-MMU-1655829", "R-BTA-1655829", "R-BTA-8874177", "R-HSA-381033"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-BTA-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-MMU-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-BTA-8874211:r:CREB3 factors activate genes", "R-MMU-8874211:r:CREB3 factors activate genes", "R-MMU-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-HSA-8874211:r:CREB3 factors activate genes", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-BTA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-BTA-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-HSA-381033:r:ATF6 (ATF6-alpha) activates chaperones"], "type": "Domain"}, "IPR008916": {"description": "Retrovirus capsid, C-terminal", "go_ids": [], "go_terms": [], "name": "Retrov_capsid_C", "pathway_ids": ["R-HSA-180910", "R-HSA-164516", "R-HSA-162585", "R-HSA-1169408", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-164525", "R-HSA-162594", "R-HSA-162592", "R-HSA-177539", "R-HSA-174490", "R-HSA-175567", "R-HSA-175474", "R-HSA-174495", "R-HSA-173107"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-174495:r:Synthesis And Processing Of GAG, GAGPOL Polyproteins", "R-HSA-173107:r:Binding and entry of HIV virion"], "type": "Homologous_superfamily"}, "IPR008917": {"description": "Transcription factor, Skn-1-like, DNA-binding domain superfamily", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "TF_DNA-bd_sf", "pathway_ids": ["R-HSA-2559580", "R-HSA-8951664", "R-HSA-8936459", "R-HSA-2871796", "R-DME-8951664", "R-HSA-9818749", "R-HSA-6796648", "R-RNO-9018519", "R-MMU-2871796", "R-MMU-8951664", "R-HSA-9818025", "R-HSA-9818030", "R-DME-209409", "R-RNO-983231", "R-MMU-9707616", "R-HSA-8943724", "R-HSA-9018519", "R-HSA-9708530", "R-DME-9762114", "R-GGA-9708530", "R-HSA-983231", "R-HSA-9755511", "R-HSA-6785807", "R-RNO-9759194", "R-MMU-2559580", "R-CEL-9759194", "R-DME-9755511", "R-MMU-9708530", "R-HSA-9818026", "R-RNO-8951664", "R-HSA-9031628", "R-HSA-5617472", "R-HSA-8940973", "R-RNO-2871796", "R-HSA-9818027", "R-HSA-9818035", "R-DME-209425", "R-HSA-8862803", "R-MMU-9755511", "R-HSA-2559582", "R-MMU-983231", "R-BTA-983231", "R-HSA-1912408", "R-HSA-450341", "R-MMU-9759194", "R-HSA-9759194", "R-DME-983231", "R-DME-209394", "R-MMU-9762114", "R-HSA-9762114", "R-GGA-9707616", "R-HSA-2173796", "R-HSA-9818028", "R-CEL-9755511", "R-RNO-9755511", "R-HSA-9707616", "R-HSA-210745", "R-HSA-9679191", "R-DME-9759194", "R-HSA-9673324", "R-HSA-9725371", "R-HSA-9909649", "R-RNO-2559580", "R-HSA-5687128", "R-HSA-9707587", "R-RNO-9762114", "R-HSA-9818032", "R-MMU-450341", "R-RNO-450341", "R-GGA-437986", "R-HSA-9725370", "R-CEL-9762114", "R-CEL-8951664"], "pathways": ["R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8951664:r:Neddylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-DME-8951664:r:Neddylation", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-MMU-8951664:r:Neddylation", "R-HSA-9818025:r:NFE2L2 regulating TCA cycle genes", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-DME-209409:r:Formation of the nuclear AP-1 transcription factor 'scaffolding complex'", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9707616:r:Heme signaling", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-GGA-9708530:r:Regulation of BACH1 activity", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-RNO-8951664:r:Neddylation", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-DME-209425:r:Transcriptional activtion by AP-1 transcription factor", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-450341:r:Activation of the AP-1 family of transcription factors", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-GGA-9707616:r:Heme signaling", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9707616:r:Heme signaling", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9707587:r:Regulation of HMOX1 expression and activity", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-450341:r:Activation of the AP-1 family of transcription factors", "R-RNO-450341:r:Activation of the AP-1 family of transcription factors", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation"], "type": "Homologous_superfamily"}, "IPR008918": {"description": "Helix-hairpin-helix motif, class 2", "go_ids": ["GO:0003677", "GO:0003824"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003824:catalytic activity:F"], "name": "HhH2", "pathway_ids": ["R-RNO-174437", "R-HSA-5693616", "R-HSA-5693579", "R-GGA-174437", "R-GGA-110362", "R-RNO-5685939", "R-MMU-6804756", "R-BTA-5685939", "R-RNO-110362", "R-CEL-69166", "R-MMU-5693616", "R-DRE-110362", "R-MMU-5685938", "R-MMU-69473", "R-SPO-5696395", "R-MMU-5696395", "R-HSA-9709570", "R-HSA-5693607", "R-CEL-5685939", "R-MMU-174437", "R-MMU-5693568", "R-SPO-5685939", "R-PFA-69166", "R-SPO-69166", "R-MMU-5358565", "R-DME-5651801", "R-SPO-5358565", "R-MMU-5651801", "R-HSA-69473", "R-HSA-110362", "R-GGA-5685939", "R-XTR-110362", "R-HSA-6804756", "R-GGA-5651801", "R-DRE-5358565", "R-SCE-69166", "R-HSA-5696395", "R-HSA-9704331", "R-CEL-5651801", "R-HSA-5693554", "R-SCE-6782135", "R-SPO-5651801", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-5358606", "R-HSA-9704646", "R-BTA-174437", "R-DRE-5685939", "R-DME-5358565", "R-DRE-69166", "R-DME-5685939", "R-RNO-69166", "R-MMU-110362", "R-BTA-5651801", "R-BTA-69166", "R-MMU-5685939", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5696400", "R-MMU-5693607", "R-HSA-9701192", "R-DDI-110362", "R-XTR-5685939", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-9709603", "R-HSA-5651801", "R-HSA-69166", "R-HSA-5685939", "R-BTA-110362", "R-DDI-69166", "R-HSA-162594", "R-SPO-5696400", "R-MMU-69166", "R-RNO-5651801", "R-HSA-5696400", "R-DRE-5651801", "R-HSA-5358565", "R-SPO-6782135", "R-HSA-174437", "R-GGA-69166", "R-DME-69166"], "pathways": ["R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-GGA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-CEL-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-PFA-69166:r:Removal of the Flap Intermediate", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-GGA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-XTR-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision 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"R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-69166:r:Removal of the Flap Intermediate", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Conserved_site"}, "IPR008919": {"description": "Retrovirus capsid, N-terminal", "go_ids": ["GO:0016032"], "go_terms": ["GO:0016032:viral process:P"], "name": "Retrov_capsid_N", "pathway_ids": ["R-HSA-180910", "R-HSA-164516", "R-HSA-162585", "R-HSA-1169408", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-164525", "R-HSA-162594", "R-HSA-162592", "R-HSA-177539", "R-HSA-174490", "R-HSA-175567", "R-HSA-175474", "R-HSA-174495", "R-HSA-173107"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", 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"R-RNO-5685938", "R-HSA-6782210", "R-BTA-5656169", "R-BTA-5696400", "R-SCE-176187", "R-HSA-176187", "R-MMU-5696400", "R-MMU-5693607", "R-DME-176187", "R-BTA-5655862", "R-GGA-5656121", "R-MMU-5656169", "R-BTA-69091", "R-HSA-5651801", "R-RNO-5685942", "R-DME-5656169", "R-MMU-5656121", "R-BTA-5656121", "R-DME-5696400", "R-SPO-110320", "R-SPO-6782210", "R-RNO-5696400", "R-HSA-5696400", "R-DME-6782210", "R-BTA-110320", "R-RNO-110312", "R-CEL-69091", "R-CEL-176187", "R-BTA-5685938", "R-HSA-5693616", "R-SCE-69091", "R-HSA-5696397", "R-GGA-174411", "R-MMU-110320", "R-RNO-176187", "R-DME-5656121", "R-HSA-5655862", "R-HSA-9709570", "R-HSA-5693607", "R-SPO-69091", "R-GGA-6782135", "R-BTA-5693607", "R-HSA-5656121", "R-GGA-5696400", "R-CEL-110312", "R-RNO-6782210", "R-GGA-110320", "R-MMU-5651801", "R-DME-110320", "R-RNO-5693607", "R-DME-69091", "R-HSA-110312", "R-GGA-6782210", "R-RNO-69473", "R-GGA-5656169", "R-GGA-5651801", "R-MMU-176187", "R-MMU-6782210", "R-CEL-5651801", "R-MMU-5696397", "R-MMU-174411", "R-SCE-6782135", "R-SPO-5651801", "R-HSA-110314", "R-DDI-6782135", "R-GGA-5685938", "R-BTA-69473", "R-MMU-6782135", "R-BTA-110312", "R-SPO-5655862", "R-MMU-110312", "R-SPO-110312", "R-DME-5696397", "R-GGA-5655862", "R-GGA-353303", "R-DME-110312", "R-CEL-5656169", "R-RNO-6804756", "R-HSA-5656169", "R-SCE-6782210", "R-HSA-5685938", "R-RNO-174411", "R-MMU-5655862", "R-SPO-5696397", "R-GGA-351451", "R-GGA-5696397", "R-DDI-69091", "R-RNO-6782135", "R-CEL-5655862", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-174411", "R-RNO-110320", "R-CEL-5696397", "R-RNO-69091", "R-SPO-5696400", "R-DME-174411", "R-BTA-5685942", "R-HSA-69091", "R-SPO-6782135", "R-RNO-5651801", "R-HSA-110320", "R-MMU-69091"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SPO-5656169:r:Termination of translesion DNA synthesis", 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ligation in GG-NER", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-6782135:r:Dual incision in TC-NER", "R-CEL-174411:r:Polymerase switching on the C-strand of the telomere", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-BTA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-110312:r:Translesion synthesis by REV1", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-69091:r:Polymerase switching", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-BTA-69091:r:Polymerase switching", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-RNO-110312:r:Translesion synthesis by REV1", "R-CEL-69091:r:Polymerase switching", "R-CEL-176187:r:Activation of ATR in response to replication stress", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SCE-69091:r:Polymerase switching", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-DME-5656121:r:Translesion synthesis by POLI", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-SPO-69091:r:Polymerase switching", "R-GGA-6782135:r:Dual incision in TC-NER", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-CEL-110312:r:Translesion synthesis by REV1", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DME-110320:r:Translesion Synthesis by POLH", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DME-69091:r:Polymerase switching", "R-HSA-110312:r:Translesion synthesis by REV1", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-GGA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch 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"R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-69091:r:Polymerase switching", "R-SPO-6782135:r:Dual incision in TC-NER", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-MMU-69091:r:Polymerase switching"], "type": "Homologous_superfamily"}, "IPR008922": {"description": "Di-copper centre-containing domain superfamily", "go_ids": [], "go_terms": [], "name": "Di-copper_centre_dom_sf", "pathway_ids": ["R-SSC-5662702", "R-HSA-9824585", "R-HSA-5662702", "R-CEL-5662702", "R-MMU-5662702"], "pathways": ["R-SSC-5662702:r:Melanin biosynthesis", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-5662702:r:Melanin biosynthesis", "R-CEL-5662702:r:Melanin biosynthesis", "R-MMU-5662702:r:Melanin biosynthesis"], "type": "Homologous_superfamily"}, "IPR008924": {"description": "Methyl-coenzyme M reductase, alpha/beta subunit, C-terminal", "go_ids": ["GO:0015948", "GO:0050524"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_asu/bsu_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR008925": {"description": "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily", "go_ids": ["GO:0000049"], "go_terms": ["GO:0000049:tRNA binding:F"], "name": "aa_tRNA-synth_I_cd-bd_sf", "pathway_ids": ["PWY-5188", "R-HSA-379726"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR008926": {"description": "Ribonucleotide reductase R1 subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "RNR_R1-su_N", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210", "R-DRE-499943", "R-DME-499943", "R-HSA-499943", "R-MMU-499943", "R-CEL-499943"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Homologous_superfamily"}, "IPR008927": {"description": "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "6-PGluconate_DH-like_C_sf", "pathway_ids": ["R-RNO-1482798", "R-HSA-71336", "R-DDI-8964539", "R-CEL-77348", "R-RNO-1483166", "R-DRE-390247", "R-RNO-173599", "R-HSA-77346", "R-MMU-77352", "R-SSC-77346", "R-DRE-8964539", "R-RNO-77305", "R-RNO-9033241", "R-MMU-77346", "R-RNO-77285", "R-CEL-8964539", "R-MMU-1482798", "R-SSC-77305", "R-HSA-173599", "R-HSA-77352", "R-CEL-77346", "R-SPO-71336", "R-CEL-71336", "R-SSC-77352", "R-BTA-8964539", "R-BTA-70895", "R-CEL-9837999", "R-MMU-77350", "R-SSC-1482798", "R-HSA-70895", "R-HSA-77348", "R-CEL-77310", "R-MMU-77348", "R-RNO-71336", "R-DME-70895", "R-DME-173599", "R-MMU-1483166", "R-DRE-1483166", "R-HSA-8964539", "R-BTA-5661270", "R-SPO-8964539", "R-HSA-77310", "R-CEL-173599", "R-SSC-77285", "R-HSA-390247", "R-MMU-390247", "R-MMU-71336", "R-RNO-77352", "R-RNO-5661270", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-CEL-77350", "R-DDI-71336", "R-DDI-70895", "R-RNO-77310", "R-HSA-77350", 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"R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SSC-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DRE-8964539:r:Glutamate and glutamine metabolism", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-SSC-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SPO-71336:r:Pentose phosphate pathway", "R-CEL-71336:r:Pentose phosphate pathway", "R-SSC-77352:r:Beta oxidation of butanoyl-CoA to 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"R-CEL-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-71336:r:Pentose phosphate pathway", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-CEL-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DDI-71336:r:Pentose phosphate pathway", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-1483166:r:Synthesis of PA", 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genes", "R-SSC-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-SSC-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-CEL-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-CEL-1483166:r:Synthesis of PA", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-SCE-1483166:r:Synthesis of PA", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Homologous_superfamily"}, "IPR008928": {"description": "Six-hairpin glycosidase superfamily", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "6-hairpin_glycosidase_sf", "pathway_ids": ["R-MMU-70221", "R-HSA-6798695", "R-HSA-189085", "R-HSA-532668", "R-HSA-70221", "R-HSA-9683686", "R-RNO-9840310", "R-MMU-9840310", "R-DME-70221", "R-HSA-9694548", "R-HSA-4793954", "R-HSA-9840310", "R-SCE-6798695", "R-DME-9840310", "R-RNO-9768727", "R-HSA-446210", "R-CEL-70221", "R-RNO-446210", "R-RNO-70221", "R-SCE-70221", "R-SSC-446210", "R-MMU-446210", "R-HSA-9768727", "R-MMU-9768727"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-9683686:r:Maturation of spike protein", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-DME-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-4793954:r:Defective MOGS causes CDG-2b", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-9840310:r:Glycosphingolipid catabolism", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-CEL-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-SSC-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "type": "Homologous_superfamily"}, "IPR008929": {"description": "Chondroitin AC/alginate lyase", "go_ids": [], "go_terms": [], "name": "Chondroitin_lyas", "pathway_ids": ["R-MMU-2022923", "R-HSA-2022923"], "pathways": ["R-MMU-2022923:r:DS-GAG biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis"], "type": "Homologous_superfamily"}, "IPR008930": {"description": "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid", "go_ids": [], "go_terms": [], "name": "Terpenoid_cyclase/PrenylTrfase", "pathway_ids": ["R-MMU-9648002", "R-SCE-8873719", "R-SCE-6803205", "R-HSA-6803205", "R-DME-9758881", "R-MMU-166665", "R-MMU-418594", "R-MMU-9953170", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-RNO-6803205", "R-HSA-977606", "R-RNO-8957275", "R-MMU-174577", "R-BTA-381426", "R-MMU-2514859", "R-HSA-174577", "R-SPO-8873719", "R-RNO-9648002", "R-DDI-6803205", "R-HSA-9969896", "R-SPO-9969896", "R-CEL-6803205", "R-HSA-8963896", "R-RNO-9953170", "R-MMU-977606", "R-DME-6798695", "R-HSA-9679191", "R-HSA-9758890", "R-DDI-9648002", "R-BTA-174577", "R-MMU-8873719", "R-BTA-6803205", "R-MMU-8963896", "R-HSA-418594", "R-RNO-166665", "R-RNO-375276", "R-RNO-173736", "R-RNO-8873719", "R-CEL-8873719", "R-HSA-8957275", "R-DDI-9969896", "R-HSA-2426168", "R-HSA-9953170", "R-RNO-9969896", "R-HSA-6798695", "R-SCE-9969896", "R-BTA-8873719", "R-MMU-163125", "R-MMU-6803205", "R-DDI-8873719", "R-HSA-9920588", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-BTA-2514859", "R-MMU-375276", "R-HSA-3359454", "R-MMU-8957275", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-BTA-9953170", "R-BTA-418594", "R-HSA-166665", "R-SPO-9648002", "R-MMU-381426", "R-HSA-3359485", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-BTA-198933", "R-RNO-198933", "R-HSA-2514859", "R-DME-9758890", "R-BTA-9648002", "R-HSA-9660826", "R-MMU-140837", "R-MMU-9969896", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", 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degranulation", "R-RNO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-174577:r:Activation of C3 and C5", "R-SPO-8873719:r:RAB geranylgeranylation", "R-RNO-9648002:r:RAS processing", "R-DDI-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis", "R-CEL-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-8963896:r:HDL assembly", "R-RNO-9953170:r:GBP-mediated host defense", "R-MMU-977606:r:Regulation of Complement cascade", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9758890:r:Transport of RCbl within the body", "R-DDI-9648002:r:RAS processing", "R-BTA-174577:r:Activation of C3 and C5", "R-MMU-8873719:r:RAB geranylgeranylation", "R-BTA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-MMU-8963896:r:HDL assembly", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-RNO-173736:r:Alternative complement activation", "R-RNO-8873719:r:RAB geranylgeranylation", "R-CEL-8873719:r:RAB geranylgeranylation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9953170:r:GBP-mediated host defense", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-BTA-8873719:r:RAB geranylgeranylation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DDI-8873719:r:RAB geranylgeranylation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-3359454:r:Defective TCN2 causes TCN2 deficiency", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-BTA-9953170:r:GBP-mediated host defense", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-SPO-9648002:r:RAS processing", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3359485:r:Defective CD320 causes MMATC", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-9758890:r:Transport of RCbl within the body", "R-BTA-9648002:r:RAS processing", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9648002:r:RAS processing", "R-DDI-9953170:r:GBP-mediated host defense", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation", "R-SCE-9648002:r:RAS processing", "R-RNO-166663:r:Initial triggering of complement", "R-SPO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-8873719:r:RAB geranylgeranylation", "R-BTA-173736:r:Alternative complement activation"], "type": "Homologous_superfamily"}, "IPR008932": {"description": "Large ribosomal subunit protein bL12, oligomerization", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bL12_oligo", "pathway_ids": ["R-BTA-5389840", "R-MMU-9837999", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9837999", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Domain"}, "IPR008935": {"description": "Virus capsid protein, alpha-helical", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Virus_capsid_a-hlx_vir", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR008936": {"description": "Rho GTPase activation protein", "go_ids": [], "go_terms": [], "name": "Rho_GTPase_activation_prot", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-HSA-9842640", "R-MMU-1250342", "R-CFA-9013409", "R-MMU-8856828", "R-BTA-198203", "R-HSA-6802952", "R-RNO-9013409", "R-MMU-6811558", "R-MMU-5654720", "R-BTA-5673001", "R-HSA-912631", "R-BTA-8851907", "R-RNO-512988", "R-RNO-416550", "R-BTA-5654710", "R-RNO-912631", "R-HSA-5654695", "R-RNO-399954", "R-MMU-201556", "R-BTA-4420097", "R-SCE-8980692", "R-BTA-6811558", "R-HSA-512988", "R-RNO-416476", "R-RNO-193648", "R-MMU-186763", "R-SCE-9696273", "R-HSA-6802955", "R-MMU-8849471", "R-MMU-6811434", "R-DDI-6798695", "R-MMU-9035034", "R-CFA-9013148", "R-HSA-6802948", "R-HSA-983695", "R-MMU-399955", "R-DDI-5673001", "R-RNO-9013148", "R-RNO-5663220", "R-XTR-9013148", "R-MMU-912526", "R-XTR-9013404", "R-HSA-211728", "R-DDI-5674135", "R-DRE-9035034", "R-DME-416572", "R-HSA-399954", "R-MMU-1963642", "R-HSA-1855204", "R-HSA-389357", "R-DRE-9013026", "R-BTA-8980692", "R-DRE-8980692", "R-RNO-2730905", "R-MMU-9696264", "R-DME-416700", "R-RNO-9013420", "R-BTA-5654689", "R-HSA-9680350", "R-BTA-1660499", "R-MMU-5674135", "R-BTA-430116", "R-RNO-8980692", "R-RNO-1257604", "R-XTR-9013026", "R-DRE-9013404", "R-SCE-5626467", "R-CFA-8849471", "R-CFA-9696264", "R-RNO-416482", "R-BTA-9927354", "R-MMU-2132295", "R-HSA-9013148", "R-HSA-1963642", "R-RNO-3928662", "R-CEL-9013406", "R-RNO-8856828", "R-BTA-8876198", "R-RNO-8985586", "R-GGA-9013149", "R-CFA-9696270", "R-HSA-112399", "R-DDI-9833482", "R-CEL-8856828", "R-RNO-399956", "R-BTA-180292", "R-HSA-5655332", "R-HSA-9696270", "R-DDI-936440", "R-DRE-9013424", "R-HSA-109704", "R-MMU-9013424", "R-MMU-1257604", "R-HSA-9842663", "R-DDI-5675221", "R-RNO-5654689", "R-BTA-416482", "R-CFA-9696273", "R-RNO-9013423", "R-XTR-8980692", "R-HSA-9009391", "R-DRE-9013420", "R-BTA-983695", "R-BTA-9696264", "R-MMU-8851907", "R-GGA-8980692", "R-RNO-983695", "R-BTA-210993", "R-BTA-9027276", "R-MMU-9696273", "R-HSA-9725370", "R-HSA-8849469", "R-MMU-416476", "R-HSA-6798695", "R-DDI-5218921", "R-CEL-8980692", "R-HSA-180292", "R-MMU-9013106", "R-BTA-202424", "R-HSA-8856828", "R-CEL-6798695", "R-CEL-9013409", "R-MMU-4420097", "R-HSA-9670439", "R-RNO-9027276", "R-MMU-416572", "R-RNO-912526", "R-DRE-9013406", "R-DDI-5675482", "R-MMU-389357", "R-RNO-198203", "R-MMU-5654695", "R-BTA-9013409", "R-BTA-8853659", "R-MMU-399954", "R-HSA-399955", "R-HSA-1855183", "R-HSA-9673767", "R-RNO-9013404", "R-MMU-2029485", "R-HSA-9013408", "R-RNO-9013408", "R-BTA-112399", "R-DDI-8856828", "R-DDI-9013423", "R-GGA-9013406", "R-HSA-1266695", "R-RNO-5673001", "R-RNO-9927354", "R-RNO-432722", "R-HSA-9927354", "R-HSA-373753", "R-XTR-9013409", "R-MMU-1433557", "R-GGA-9013148", "R-MMU-180292", "R-HSA-210993", "R-HSA-2029482", "R-HSA-8876198", "R-GGA-9013423", "R-HSA-5673001", "R-HSA-6811558", "R-SPO-8980692", "R-HSA-5218921", "R-RNO-1433557", "R-MMU-373753", "R-SCE-9035034", "R-MMU-8876198", "R-MMU-9013406", "R-DRE-399956", "R-MMU-9027276", "R-MMU-6798695", "R-HSA-1257604", "R-MMU-416700", "R-MMU-5654710", "R-DRE-9013423", "R-HSA-416550", "R-SPO-6798695", "R-HSA-399956", "R-HSA-2132295", "R-BTA-5654720", "R-RNO-109704", "R-MMU-9013148", "R-RNO-1660514", "R-HSA-1660499", "R-CFA-9013149", "R-RNO-2029482", "R-MMU-9842663", "R-BTA-186763", "R-MMU-198203", "R-HSA-9673770", "R-BTA-201556", "R-HSA-416700", "R-HSA-9035034", "R-DME-9013409", "R-DME-9013406", "R-DRE-9013149", "R-MMU-5658442", "R-SCE-9013424", "R-HSA-6802953", "R-HSA-432722", "R-BTA-2029485", "R-BTA-9013420", "R-RNO-1266695", "R-DDI-3295583", "R-DME-8876198", "R-CEL-416572", "R-HSA-1660514", "R-SPO-9035034", "R-MMU-2029482", "R-HSA-186763", "R-DRE-9013148", "R-RNO-2424491", "R-MMU-9927354", "R-HSA-983189", "R-MMU-416482", "R-HSA-5654710", "R-RNO-1855204", "R-HSA-9013406", "R-HSA-9664422", "R-HSA-202424", "R-DDI-1169092", "R-DME-9013423", "R-HSA-9013409", "R-HSA-9607240", "R-MMU-1266695", "R-BTA-9696273", "R-MMU-114604", "R-GGA-9013026", "R-HSA-9918485", "R-MMU-9013408", "R-DME-5658442", "R-RNO-9607240", "R-MMU-9013409", "R-MMU-9009391", "R-MMU-210993", "R-RNO-9009391", "R-BTA-1963642", "R-DME-9013148", "R-HSA-6811434", "R-MMU-9013420", "R-DDI-5213460", "R-HSA-8853659", "R-RNO-6811558", "R-HSA-9603381", "R-GGA-9013404", "R-RNO-1963642", "R-DDI-5673000", "R-DRE-5663220", "R-MMU-5673001", "R-HSA-114604", "R-SPO-5626467", "R-RNO-1855183", "R-DME-9013149", "R-CFA-9013406", "R-CFA-8980692", "R-HSA-5654689", "R-RNO-210993", "R-HSA-2424491", "R-HSA-416482", "R-XTR-9013408", "R-SPO-9013148", "R-HSA-5637810", "R-HSA-9696264", "R-MMU-9013423", "R-DME-416482", "R-MMU-193648", "R-RNO-9696264", "R-HSA-9013026", "R-MMU-2730905", "R-HSA-9768727", "R-MMU-9768727", "R-BTA-2424491", "R-MMU-5663220", "R-RNO-8851907", "R-HSA-9656223", "R-HSA-1839117", "R-MMU-416550", "R-HSA-5655253", "R-HSA-416572", "R-RNO-9842663", "R-MMU-430116", "R-RNO-9035034", "R-MMU-8980692", "R-SCE-6798695", "R-HSA-2029485", "R-MMU-983189", "R-HSA-9013106", "R-HSA-9665348", "R-BTA-9013148", "R-BTA-9013423", "R-HSA-9013423", "R-SPO-9013406", "R-BTA-1266695", "R-BTA-5654695", "R-HSA-8851907", "R-BTA-912526", "R-HSA-9028335", "R-MMU-512988", "R-HSA-2730905", "R-SPO-9013420", "R-HSA-9027276", "R-BTA-512988", "R-MMU-202424", "R-BTA-1433557", "R-CEL-9013423", "R-BTA-8856828", "R-SCE-9013409", "R-RNO-8849471", "R-HSA-5655291", "R-MMU-912631", "R-MMU-109704", "R-BTA-9696270", "R-MMU-5626467", "R-RNO-416700", "R-RNO-1250342", "R-DDI-392517", "R-BTA-9009391", "R-SCE-9013106", "R-MMU-1660499", "R-BTA-109704", "R-RNO-1660499", "R-RNO-399955", "R-XTR-9013406", "R-BTA-9013404", "R-HSA-912526", "R-HSA-201556", "R-BTA-1257604", "R-RNO-5654695", "R-HSA-5663220", "R-DDI-9013404", "R-HSA-9856530", "R-BTA-9607240", "R-MMU-5654689", "R-MMU-9013149", "R-BTA-389357", "R-DME-9013420", "R-XTR-9013106", "R-DDI-354192", "R-HSA-5674135", "R-DRE-399954", "R-MMU-9607240", "R-BTA-9013424", "R-RNO-5654710", "R-HSA-430116", "R-CEL-9013424", "R-RNO-9013149", "R-MMU-9013404", "R-HSA-9013424", "R-DDI-5626467", "R-CEL-416482", "R-GGA-9013106", "R-HSA-3928662", "R-BTA-9035034", "R-HSA-8849471", "R-HSA-4420097", "R-SPO-9013106", "R-CEL-9035034", "R-RNO-112399", "R-DME-9035034", "R-RNO-2029485", "R-RNO-9013424", "R-SCE-9013149", "R-HSA-9649948", "R-CFA-9013408", "R-GGA-9013409", "R-RNO-202424", "R-MMU-1660514", "R-SCE-9013420", "R-RNO-9013406", "R-HSA-9664565", "R-HSA-5655302", "R-CEL-9013148", "R-RNO-389357", "R-RNO-201556", "R-DDI-193648", "R-DME-8980692", "R-DDI-5658442", "R-RNO-8853659", "R-MMU-8853659", "R-HSA-2219530", "R-RNO-9696273", "R-BTA-912631", "R-HSA-6785807", "R-HSA-9013404", "R-SCE-9013148", "R-BTA-416476", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-5658442", "R-HSA-9703648", "R-CFA-9013106", "R-HSA-381676", "R-HSA-5654720", "R-SPO-9013424", "R-BTA-114604", "R-MMU-399956", "R-HSA-198203", "R-BTA-9013106", "R-RNO-4420097", "R-RNO-430116", "R-SCE-9013423", "R-HSA-5626467", "R-RNO-9696270", "R-MMU-432722", "R-DDI-8849471", "R-CEL-416700", "R-CFA-9013404", "R-HSA-416476", "R-HSA-1250342", "R-DDI-9013149", "R-CEL-9013149", "R-DDI-381676", "R-HSA-9615017", "R-SCE-9013406", "R-CEL-8876198", "R-HSA-6802946", "R-HSA-1236382", "R-XTR-9696264", "R-XTR-9013423", "R-SPO-9013409", "R-DME-8856828", "R-RNO-9013106", "R-MMU-1855183", "R-MMU-1855204", "R-DME-350407", "R-DDI-1169408", "R-HSA-193648", "R-HSA-9013420", "R-DDI-171007", "R-HSA-9013508", "R-MMU-8849469", "R-BTA-1250342", "R-CFA-416550", "R-MMU-8985586", "R-MMU-983695", "R-HSA-1433557", "R-XTR-9035034", "R-RNO-180292", "R-MMU-112399", "R-BTA-9013408", "R-HSA-9703465", "R-BTA-2730905", "R-HSA-428543", "R-RNO-5218921", "R-HSA-8985586", "R-DDI-983168", "R-DDI-9909505", "R-RNO-114604", "R-MMU-9013026", "R-RNO-5658442", "R-RNO-5654720", "R-MMU-2424491", "R-DME-8849471", "R-MMU-9696270", "R-RNO-186763", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-CFA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-BTA-198203:r:PI3K/AKT activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-912631:r:Regulation of signaling by CBL", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-912631:r:Regulation of signaling by CBL", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-201556:r:Signaling by ALK", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SCE-8980692:r:RHOA GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-SCE-9696273:r:RND1 GTPase cycle", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-DRE-9035034:r:RHOF GTPase cycle", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-9696264:r:RND3 GTPase cycle", "R-DME-416700:r:Other semaphorin interactions", "R-RNO-9013420:r:RHOU GTPase cycle", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-BTA-430116:r:GP1b-IX-V activation signalling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-XTR-9013026:r:RHOB GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-SCE-5626467:r:RHO GTPases activate IQGAPs", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-9696264:r:RND3 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-CFA-9696270:r:RND2 GTPase cycle", "R-HSA-112399:r:IRS-mediated signalling", "R-DDI-9833482:r:PKR-mediated signaling", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-BTA-180292:r:GAB1 signalosome", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DRE-9013424:r:RHOV GTPase cycle", "R-HSA-109704:r:PI3K Cascade", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-CFA-9696273:r:RND1 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-XTR-8980692:r:RHOA GTPase cycle", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-9013420:r:RHOU GTPase cycle", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-9696264:r:RND3 GTPase cycle", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-GGA-8980692:r:RHOA GTPase cycle", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-210993:r:Tie2 Signaling", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-BTA-9013409:r:RHOJ GTPase cycle", "R-BTA-8853659:r:RET signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-112399:r:IRS-mediated signalling", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-373753:r:Nephrin family interactions", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-373753:r:Nephrin family interactions", "R-SCE-9035034:r:RHOF GTPase cycle", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-2132295:r:MHC class II antigen presentation", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-109704:r:PI3K Cascade", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9842663:r:Signaling by LTK", "R-BTA-186763:r:Downstream signal transduction", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-BTA-201556:r:Signaling by ALK", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-1266695:r:Interleukin-7 signaling", "R-DDI-3295583:r:TRP channels", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SPO-9035034:r:RHOF GTPase cycle", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-186763:r:Downstream signal transduction", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-RNO-2424491:r:DAP12 signaling", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-HSA-983189:r:Kinesins", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-1169092:r:Activation of RAS in B cells", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9607240:r:FLT3 Signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-GGA-9013026:r:RHOB GTPase cycle", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-RNO-9607240:r:FLT3 Signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-210993:r:Tie2 Signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-8853659:r:RET signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-DDI-5673000:r:RAF activation", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-SPO-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-CFA-8980692:r:RHOA GTPase cycle", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-XTR-9013408:r:RHOG GTPase cycle", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-2424491:r:DAP12 signaling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-9842663:r:Signaling by LTK", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-983189:r:Kinesins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-BTA-1266695:r:Interleukin-7 signaling", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-SCE-9013409:r:RHOJ GTPase cycle", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-912631:r:Regulation of signaling by CBL", "R-MMU-109704:r:PI3K Cascade", "R-BTA-9696270:r:RND2 GTPase cycle", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-416700:r:Other semaphorin interactions", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-DDI-392517:r:Rap1 signalling", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-SCE-9013106:r:RHOC GTPase cycle", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-109704:r:PI3K Cascade", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-201556:r:Signaling by ALK", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9607240:r:FLT3 Signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-9013420:r:RHOU GTPase cycle", "R-XTR-9013106:r:RHOC GTPase cycle", "R-DDI-354192:r:Integrin signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-9607240:r:FLT3 Signaling", "R-BTA-9013424:r:RHOV GTPase cycle", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-GGA-9013106:r:RHOC GTPase cycle", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-9013106:r:RHOC GTPase cycle", "R-CEL-9035034:r:RHOF GTPase cycle", "R-RNO-112399:r:IRS-mediated signalling", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013424:r:RHOV GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CFA-9013408:r:RHOG GTPase cycle", "R-GGA-9013409:r:RHOJ GTPase cycle", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-9013420:r:RHOU GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-201556:r:Signaling by ALK", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DME-8980692:r:RHOA GTPase cycle", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-RNO-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-RNO-9696273:r:RND1 GTPase cycle", "R-BTA-912631:r:Regulation of signaling by CBL", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-CFA-9013106:r:RHOC GTPase cycle", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-SPO-9013424:r:RHOV GTPase cycle", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-HSA-198203:r:PI3K/AKT activation", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CEL-416700:r:Other semaphorin interactions", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-XTR-9696264:r:RND3 GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-SPO-9013409:r:RHOJ GTPase cycle", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DME-350407:r:RHO1 GTPase cycle", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DDI-171007:r:p38MAPK events", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-XTR-9035034:r:RHOF GTPase cycle", "R-RNO-180292:r:GAB1 signalosome", "R-MMU-112399:r:IRS-mediated signalling", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9696270:r:RND2 GTPase cycle", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR008937": {"description": "Ras-like guanine nucleotide exchange factor", "go_ids": ["GO:0005085", "GO:0007264"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0007264:small GTPase-mediated signal transduction:P"], "name": "Ras-like_GEF", "pathway_ids": ["R-HSA-9607240", "R-MMU-180336", "R-HSA-2871796", "R-HSA-912631", "R-MMU-210993", "R-HSA-9027284", "R-HSA-442982", "R-CEL-9607240", "R-MMU-5654706", "R-MMU-8851805", "R-HSA-8853659", "R-DME-74751", "R-MMU-5673001", "R-MMU-186763", "R-RNO-193648", "R-DME-1433559", "R-MMU-167044", "R-DME-9607240", "R-DME-9013149", "R-HSA-983695", "R-HSA-2424491", "R-MMU-392517", "R-DDI-5673001", "R-HSA-416482", "R-RNO-9013148", "R-HSA-8983432", "R-SCE-193648", "R-CEL-74751", "R-HSA-5637810", "R-HSA-5654699", "R-MMU-912526", "R-MMU-171007", "R-HSA-1433559", "R-HSA-5654700", "R-CEL-1433557", "R-CEL-8851805", "R-DME-193648", "R-MMU-179812", "R-DME-416482", "R-MMU-193648", "R-DRE-8980692", "R-MMU-2730905", "R-MMU-5654712", "R-HSA-179812", "R-MMU-354192", "R-HSA-392517", "R-HSA-9680350", "R-HSA-5655253", "R-DME-180336", "R-DME-5673001", "R-MMU-8980692", "R-MMU-5654699", "R-RNO-8980692", "R-HSA-9665348", "R-HSA-2428933", "R-SCE-381676", "R-CEL-2179392", "R-DME-1433557", "R-HSA-9013423", "R-XTR-5673001", "R-RNO-416482", "R-RNO-354192", "R-CEL-5654712", "R-MMU-1250347", "R-CEL-354192", "R-HSA-9013148", "R-MMU-5654704", "R-HSA-1250196", "R-HSA-2730905", "R-MMU-112412", "R-HSA-5654719", "R-DME-5654699", "R-CEL-193648", "R-HSA-1963640", "R-HSA-5655291", "R-HSA-5655332", "R-DME-5654719", "R-DME-2179392", "R-DME-112412", "R-DDI-392517", "R-DME-167044", "R-HSA-5654712", "R-HSA-2871809", "R-HSA-9034864", "R-MMU-9028731", "R-MMU-354194", "R-MMU-8983432", "R-HSA-74749", "R-HSA-9842663", "R-DME-2730905", "R-HSA-180336", "R-DME-74749", "R-XTR-354192", "R-DME-5654712", "R-RNO-422356", "R-CEL-179812", "R-HSA-9634285", "R-HSA-912526", "R-HSA-170968", "R-HSA-428540", "R-MMU-5654693", "R-DME-186763", "R-DRE-193648", "R-MMU-9013149", "R-DME-5654706", "R-MMU-74749", "R-MMU-1963640", "R-HSA-422356", "R-HSA-5654688", "R-HSA-1989781", "R-DDI-354192", "R-MMU-1433559", "R-CEL-210993", "R-HSA-8875555", "R-MMU-9607240", "R-DME-375165", "R-CEL-354194", "R-SCE-416482", "R-RNO-9013149", "R-DME-912631", "R-HSA-2179392", "R-HSA-9670439", "R-HSA-9026519", "R-CEL-416482", "R-HSA-5654693", "R-DRE-5673001", "R-CEL-5673001", "R-MMU-381676", "R-MMU-2871796", "R-RNO-392517", "R-DME-210993", "R-DME-2424491", "R-SCE-9013149", "R-CEL-1433559", "R-CEL-5654700", "R-MMU-74751", "R-XTR-1169092", "R-BTA-392517", "R-DDI-9013423", "R-HSA-9673767", "R-XTR-392517", "R-HSA-9664565", "R-RNO-5673001", "R-HSA-5655302", "R-CEL-5654693", "R-MMU-2428933", "R-DDI-193648", "R-DME-5654704", "R-HSA-9665686", "R-MMU-1433557", "R-HSA-210993", "R-MMU-8853659", "R-MMU-5654700", "R-DME-5654688", "R-SCE-354192", "R-HSA-5673001", "R-HSA-9013149", "R-DME-2871796", "R-HSA-8980692", "R-DME-8853659", "R-HSA-9703648", "R-HSA-381676", "R-CEL-1963640", "R-DME-1963640", "R-BTA-354192", "R-CEL-186763", "R-MMU-5654688", "R-DRE-416482", "R-HSA-5654704", "R-SCE-392517", "R-MMU-375165", "R-CEL-375165", "R-MMU-1169092", "R-MMU-2179392", "R-HSA-167044", "R-DME-5654700", "R-HSA-74751", "R-MMU-422356", "R-DME-5654693", "R-MMU-9013148", "R-HSA-375165", "R-HSA-1250347", "R-DDI-9013149", "R-DME-2428933", "R-MMU-9842663", "R-CEL-9013149", "R-HSA-2871837", "R-DDI-381676", "R-HSA-9673770", "R-HSA-114508", "R-CEL-5654706", "R-HSA-1169092", "R-DME-2871809", "R-HSA-1236382", "R-DRE-9013149", "R-CEL-5654699", "R-DME-1250347", "R-HSA-8851805", "R-MMU-5654719", "R-HSA-9028731", "R-HSA-171007", "R-HSA-354192", "R-HSA-193648", "R-RNO-171007", "R-DDI-171007", "R-CEL-392517", "R-HSA-5654706", "R-HSA-354194", "R-HSA-9679191", "R-MMU-983695", "R-DDI-1169092", "R-HSA-1433557", "R-RNO-381676", "R-CEL-381676", "R-CEL-180336", "R-HSA-186763", "R-RNO-1169092", "R-HSA-9703465", "R-DRE-9013148", "R-MMU-2871809", "R-HSA-112412", "R-MMU-416482", "R-MMU-2424491", "R-DME-179812", "R-DME-9013423", "R-CEL-5654704"], "pathways": ["R-HSA-9607240:r:FLT3 Signaling", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-CEL-9607240:r:FLT3 Signaling", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-HSA-8853659:r:RET signaling", "R-DME-74751:r:Insulin receptor signalling cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-RNO-193648:r:NRAGE signals death through JNK", "R-DME-1433559:r:Regulation of KIT signaling", "R-MMU-167044:r:Signalling to RAS", "R-DME-9607240:r:FLT3 Signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2424491:r:DAP12 signaling", "R-MMU-392517:r:Rap1 signalling", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SCE-193648:r:NRAGE signals death through JNK", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-171007:r:p38MAPK events", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-8851805:r:MET activates RAS signaling", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-MMU-354192:r:Integrin signaling", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-SCE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-354192:r:Integrin signaling", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-112412:r:SOS-mediated signalling", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-112412:r:SOS-mediated signalling", "R-DDI-392517:r:Rap1 signalling", "R-DME-167044:r:Signalling to RAS", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-74749:r:Signal attenuation", "R-HSA-9842663:r:Signaling by LTK", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-DME-74749:r:Signal attenuation", "R-XTR-354192:r:Integrin signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-186763:r:Downstream signal transduction", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-74749:r:Signal attenuation", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-354192:r:Integrin signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-9607240:r:FLT3 Signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DME-912631:r:Regulation of signaling by CBL", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-RNO-392517:r:Rap1 signalling", "R-DME-210993:r:Tie2 Signaling", "R-DME-2424491:r:DAP12 signaling", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-XTR-1169092:r:Activation of RAS in B cells", "R-BTA-392517:r:Rap1 signalling", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-XTR-392517:r:Rap1 signalling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-210993:r:Tie2 Signaling", "R-MMU-8853659:r:RET signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-SCE-354192:r:Integrin signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-8853659:r:RET signaling", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-354192:r:Integrin signaling", "R-CEL-186763:r:Downstream signal transduction", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-SCE-392517:r:Rap1 signalling", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-MMU-1169092:r:Activation of RAS in B cells", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-MMU-422356:r:Regulation of insulin secretion", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-9842663:r:Signaling by LTK", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-1169092:r:Activation of RAS in B cells", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-171007:r:p38MAPK events", "R-HSA-354192:r:Integrin signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-171007:r:p38MAPK events", "R-DDI-171007:r:p38MAPK events", "R-CEL-392517:r:Rap1 signalling", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-1169092:r:Activation of RAS in B cells", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-1169092:r:Activation of RAS in B cells", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-2424491:r:DAP12 signaling", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3"], "type": "Family"}, "IPR008939": {"description": "Lytic transglycosylase, superhelical U-shaped", "go_ids": ["GO:0004553", "GO:0042597"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0042597:periplasmic space:C"], "name": "Lytic_TGlycosylase_superhlx_U", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR008942": {"description": "ENTH/VHS", "go_ids": [], "go_terms": [], "name": "ENTH_VHS", "pathway_ids": ["R-RNO-6781823", "R-HSA-6798695", "R-MMU-182971", "R-MMU-8856828", "R-BTA-9706019", "R-RNO-917729", "R-SPO-5689901", "R-HSA-6807505", "R-HSA-9700645", "R-MMU-917729", "R-MMU-9770562", "R-HSA-8856828", "R-HSA-5689880", "R-BTA-5689880", "R-MMU-5689901", "R-HSA-73856", "R-CEL-432722", "R-MMU-9706019", "R-HSA-72187", "R-HSA-6781823", "R-CEL-917729", "R-MMU-5689880", "R-SCE-9770562", "R-SCE-6807505", "R-DDI-8856825", "R-HSA-9635644", "R-MMU-9013420", "R-SPO-8856825", "R-CEL-9770562", "R-SCE-9013420", "R-CEL-182971", "R-RNO-432722", "R-RNO-6782210", "R-CEL-6807505", "R-HSA-182971", "R-BTA-182971", "R-BTA-6807505", "R-MMU-72163", "R-HSA-432720", "R-RNO-432720", "R-MMU-73856", "R-GGA-6798695", "R-MMU-6807505", "R-RNO-5689880", "R-HSA-9696264", "R-HSA-72163", "R-SPO-9770562", "R-RNO-8875656", "R-XTR-6782210", "R-HSA-9918476", "R-SCE-8856825", "R-RNO-9696264", "R-MMU-6798695", "R-MMU-6782210", "R-MMU-9696264", "R-DME-182971", "R-XTR-6781823", "R-RNO-9013420", "R-CEL-8856825", "R-HSA-5689901", "R-DME-432720", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-8856825", "R-HSA-8854214", "R-HSA-977225", "R-MMU-77595", "R-MMU-432722", "R-CEL-73856", "R-CEL-77595", "R-HSA-77595", "R-MMU-6781823", "R-HSA-9636383", "R-HSA-6782210", "R-DME-8856828", "R-RNO-8856828", "R-SPO-9013420", "R-MMU-432720", "R-HSA-432722", "R-BTA-6807004", "R-HSA-9918481", "R-DME-917729", "R-BTA-8856828", "R-BTA-9013420", "R-CEL-8856828", "R-DME-8856825", "R-HSA-9013420", "R-RNO-8856825", "R-CEL-6807004", "R-HSA-9770562", "R-HSA-9706019", "R-BTA-432720", "R-RNO-6782135", "R-RNO-9706019", "R-DME-432722", "R-HSA-6782135", "R-HSA-6807004", "R-HSA-917729", "R-BTA-8856825", "R-RNO-6807004", "R-MMU-72187", "R-HSA-8856825", "R-MMU-8875656", "R-XTR-6782135", "R-CEL-9013420", "R-MMU-6807004", "R-HSA-8875656", "R-RNO-182971", "R-BTA-917729", "R-HSA-9725370", "R-HSA-8875360", "R-DME-5689880", "R-DME-9013420"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-182971:r:EGFR downregulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-BTA-9706019:r:RHOBTB3 ATPase cycle", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SPO-5689901:r:Metalloprotease DUBs", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-5689901:r:Metalloprotease DUBs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-9770562:r:mRNA Polyadenylation", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9635644:r:Inhibition of membrane repair", "R-MMU-9013420:r:RHOU GTPase cycle", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-9770562:r:mRNA Polyadenylation", "R-SCE-9013420:r:RHOU GTPase cycle", "R-CEL-182971:r:EGFR downregulation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-182971:r:EGFR downregulation", "R-BTA-182971:r:EGFR downregulation", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-RNO-8875656:r:MET receptor recycling", "R-XTR-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9696264:r:RND3 GTPase cycle", "R-DME-182971:r:EGFR downregulation", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-9013420:r:RHOU GTPase cycle", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5689901:r:Metalloprotease DUBs", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-SPO-9013420:r:RHOU GTPase cycle", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-6807004:r:Negative regulation of MET activity", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-6807004:r:Negative regulation of MET activity", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-6782135:r:Dual incision in TC-NER", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8875656:r:MET receptor recycling", "R-XTR-6782135:r:Dual incision in TC-NER", "R-CEL-9013420:r:RHOU GTPase cycle", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-8875656:r:MET receptor recycling", "R-RNO-182971:r:EGFR downregulation", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Homologous_superfamily"}, "IPR008944": {"description": "Bacteriophage T4, Gp59, helicase assembly protein", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp59", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008947": {"description": "Phospholipase C/P1 nuclease domain superfamily", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "PLipase_C/P1_nuclease_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR008948": {"description": "L-Aspartase-like", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "L-Aspartase-like", "pathway_ids": ["R-SPO-73817", "R-MMU-9837999", "R-BTA-70921", "R-MMU-73817", "R-SCE-73817", "R-CEL-73817", "R-GGA-73817", "R-SPO-71403", "R-CEL-71403", "R-GGA-421203", "R-MMU-71403", "R-HSA-9956529", "R-HSA-9837999", "R-DDI-71403", "R-RNO-71403", "R-HSA-70921", "R-HSA-71403", "R-DDI-9837999", "R-RNO-70921", "R-SPO-70635", "R-CEL-9837999", "R-DDI-70921", "R-HSA-70635", "R-CEL-70921", "R-RNO-9837999", "R-RNO-70635", "R-DRE-71403", "R-GGA-419140", "R-DRE-9837999", "R-MMU-70635", "R-GGA-187630", "R-SPO-9837999", "R-SCE-71403", "R-SCE-9837999", "R-MMU-70921", "R-BTA-70635", "R-HSA-73817", "R-SCE-70635"], "pathways": ["R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-70921:r:Histidine catabolism", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-GGA-421203:r:De novo synthesis of AMP", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9956529:r:ASL variants cause argininosuccinate aciduria", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-70921:r:Histidine catabolism", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-70921:r:Histidine catabolism", "R-SPO-70635:r:Urea cycle", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DDI-70921:r:Histidine catabolism", "R-HSA-70635:r:Urea cycle", "R-CEL-70921:r:Histidine catabolism", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-70635:r:Urea cycle", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-GGA-419140:r:De novo synthesis of IMP", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-MMU-70635:r:Urea cycle", "R-GGA-187630:r:Arginine metabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-70921:r:Histidine catabolism", "R-BTA-70635:r:Urea cycle", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-70635:r:Urea cycle"], "type": "Homologous_superfamily"}, "IPR008949": {"description": "Isoprenoid synthase domain superfamily", "go_ids": [], "go_terms": [], "name": "Isoprenoid_synthase_dom_sf", "pathway_ids": ["R-SPO-2142789", "R-SCE-9969896", "R-HSA-1989781", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-RNO-6799198", "R-RNO-2142789", "R-MMU-9969896", "R-MMU-2142789", "R-SCE-2142789", "R-HSA-9969896", "R-DDI-2142789", "R-HSA-2142789", "R-BTA-9969896", "R-DDI-9969896", "R-BTA-6799198", "R-HSA-2426168", "R-RNO-9969896", "R-SPO-9969896"], "pathways": ["R-SPO-2142789:r:Ubiquinol biosynthesis", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-BTA-6799198:r:Complex I biogenesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Homologous_superfamily"}, "IPR008952": {"description": "Tetraspanin, EC2 domain superfamily", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Tetraspanin_EC2_sf", "pathway_ids": ["R-MMU-1300645", "R-HSA-6798695", "R-HSA-416993", "R-RNO-446107", "R-MMU-977606", "R-BTA-198933", "R-RNO-1300645", "R-RNO-198933", "R-HSA-1300645", "R-HSA-977225", "R-BTA-1300645", "R-CEL-6798695", "R-BTA-6798695", "R-RNO-114608", "R-RNO-977606", "R-HSA-114608", "R-HSA-9638630", "R-BTA-114608", "R-MMU-198933", "R-HSA-5336415", "R-HSA-2022090", "R-HSA-977606", "R-MMU-6798695", "R-HSA-198933", "R-HSA-446107", "R-BTA-977606", "R-HSA-202733", "R-RNO-6798695", "R-MMU-446107", "R-MMU-114608", "R-MMU-416993"], "pathways": ["R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-BTA-114608:r:Platelet degranulation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-BTA-977606:r:Regulation of Complement cascade", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-MMU-114608:r:Platelet degranulation", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors"], "type": "Homologous_superfamily"}, "IPR008953": {"description": "Iron hydrogenase, small subunit HydB-type", "go_ids": ["GO:0005506", "GO:0008901", "GO:0009055", "GO:0042597", "GO:0051536"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0008901:ferredoxin hydrogenase activity:F", "GO:0009055:electron transfer activity:F", "GO:0042597:periplasmic space:C", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Fe_hydrogenase_HydB", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR008954": {"description": "Moesin tail domain superfamily", "go_ids": ["GO:0003779"], "go_terms": ["GO:0003779:actin binding:F"], "name": "Moesin_tail_sf", "pathway_ids": ["R-MMU-437239", "R-RNO-437239", "R-DME-437239", "R-HSA-9662361", "R-DME-5627123", "R-HSA-437239", "R-BTA-373752", "R-HSA-8950505", "R-HSA-2029482", "R-HSA-373752", "R-MMU-2029482", "R-DME-2029482", "R-HSA-5627123", "R-HSA-9662360", "R-MMU-5627123", "R-RNO-373752", "R-MMU-373752", "R-HSA-9725370", "R-DME-373752"], "pathways": ["R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-373752:r:Netrin-1 signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-373752:r:Netrin-1 signaling", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-373752:r:Netrin-1 signaling"], "type": "Homologous_superfamily"}, "IPR008956": {"description": "Protease A inhibitor IA3 domain superfamily", "go_ids": [], "go_terms": [], "name": "IA3_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR008958": {"description": "Transglutaminase, C-terminal", "go_ids": ["GO:0018149", "GO:0003810"], "go_terms": ["GO:0018149:peptide cross-linking:P", "GO:0003810:protein-glutamine gamma-glutamyltransferase activity:F"], "name": "Transglutaminase_C", "pathway_ids": ["R-HSA-114608", "R-RNO-6809371", "R-MMU-6809371", "R-HSA-6809371", "R-MMU-140875", "R-RNO-140875", "R-HSA-6785807", "R-HSA-140875", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-RNO-6809371:r:Formation of the cornified envelope", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR008962": {"description": "PapD-like superfamily", "go_ids": [], "go_terms": [], "name": "PapD-like_sf", "pathway_ids": ["R-HSA-9013405", "R-HSA-6798695", "R-SPO-6798695", "R-SSC-9013404", "R-MMU-9013106", "R-SSC-9013408", "R-MMU-8980692", "R-RNO-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-BTA-6798695", "R-SSC-8980692", "R-HSA-9013106", "R-HSA-1660661", "R-MMU-9013404", "R-RNO-9609523", "R-SCE-9013106", "R-BTA-9609523", "R-HSA-9013404", "R-BTA-9013408", "R-BTA-1660661", "R-HSA-8980692", "R-SPO-9609523", "R-BTA-9013404", "R-BTA-8980692", "R-MMU-6798695", "R-SSC-9013106", "R-HSA-9013408", "R-SCE-9609523", "R-HSA-9609523", "R-RNO-9013408", "R-MMU-9609523", "R-RNO-9013106", "R-RNO-9013404", "R-BTA-9013106", "R-RNO-6798695"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-SSC-9013408:r:RHOG GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9013106:r:RHOC GTPase cycle", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9013408:r:RHOG GTPase cycle", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR008963": {"description": "Purple acid phosphatase-like, N-terminal", "go_ids": ["GO:0003993", "GO:0046872"], "go_terms": ["GO:0003993:acid phosphatase activity:F", "GO:0046872:metal ion binding:F"], "name": "Purple_acid_Pase-like_N", "pathway_ids": ["PWY-6348"], "pathways": ["PWY-6348:t:phosphate acquisition"], "type": "Homologous_superfamily"}, "IPR008964": {"description": "Invasin/intimin cell-adhesion fragments", "go_ids": [], "go_terms": [], "name": "Invasin/intimin_cell_adhesion", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-RNO-3301854", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230", "R-MMU-4085377", "R-MMU-4551638", "R-RNO-191859", 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"R-HSA-4086398", "R-MMU-8951430", "R-DME-210671", "R-MMU-877312", "R-MMU-202424", "R-DME-214411", "R-DME-8934593", "R-MMU-8849474", "R-RNO-9856649", "R-MMU-6804757", "R-DME-8983432", "R-MMU-9701898", "R-DME-9856649", "R-MMU-1169091", "R-MMU-8983432", "R-HSA-6811555", "R-HSA-350054", "R-CEL-8878166", "R-CEL-8939247", "R-HSA-9909649", "R-MMU-8939902", "R-HSA-201556", "R-DME-8941326", "R-HSA-8939236", "R-RNO-6783783", "R-MMU-8953750", "R-HSA-8939256", "R-MMU-5607764", "R-MMU-9020933", "R-RNO-9020956", "R-HSA-5676590", "R-HSA-9927418", "R-MMU-69541", "R-DME-933542", "R-RNO-8939243", "R-BTA-6804754", "R-MMU-9833482", "R-MMU-9008059", "R-HSA-9823730", "R-HSA-8941855", "R-RNO-202424", "R-HSA-9796292", "R-DRE-2032785", "R-HSA-8878166", "R-CEL-9856649", "R-RNO-8939247", "R-DME-8939245", "R-RNO-201556", "R-DRE-6804756", "R-MMU-8936459", "R-RNO-9020933", "R-SSC-8984722", "R-DME-9020933", "R-RNO-6804754", "R-HSA-8950505", "R-CEL-9833482", "R-DME-8878166", "R-HSA-982772", "R-MMU-9018519", "R-HSA-1169091", "R-BTA-8852276", "R-RNO-445989", "R-RNO-5689896", "R-HSA-2559586", "R-DME-8951671", "R-SSC-69895", "R-HSA-8853884", "R-DME-8931987", "R-SSC-6811555", "R-DME-1810476", "R-HSA-2559585", "R-DME-8939247", "R-HSA-1912408", "R-HSA-2025928", "R-HSA-448706", "R-MMU-5607763", "R-HSA-3214841", "R-DRE-8852276", "R-DME-5607761", "R-SSC-9020958", "R-SSC-6804754", "R-HSA-5607764", "R-DME-9020956", "R-MMU-8854691", "R-DME-8951430", "R-RNO-2559586", "R-CEL-1059683", "R-SSC-6804757", "R-HSA-390471", "R-MMU-8984722", "R-SSC-9020956", "R-RNO-5684264", "R-DME-9008059", "R-BTA-6804760", "R-SSC-8852276", "R-MMU-8939243", "R-DDI-6783783", "R-BTA-350054", "R-DME-9020591", "R-DME-8936459", "R-SSC-9701898", "R-HSA-9705462", "R-MMU-6811555", "R-DME-209228", "R-HSA-2892247", "R-DME-201556", "R-HSA-8939246", "R-RNO-186763", "R-RNO-549127"], "pathways": ["R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-9020958:r:Interleukin-21 signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-198745:r:Signalling to STAT3", "R-DRE-2559585:r:Oncogene Induced Senescence", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-4755510:r:SUMOylation of immune response proteins", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-CEL-6783783:r:Interleukin-10 signaling", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-SSC-9020933:r:Interleukin-23 signaling", "R-SSC-9833482:r:PKR-mediated signaling", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-448706:r:Interleukin-1 processing", "R-CEL-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-DME-6783783:r:Interleukin-10 signaling", "R-HSA-549127:r:SLC-mediated transport of organic cations", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-SSC-1266695:r:Interleukin-7 signaling", "R-DME-202424:r:Downstream TCR signaling", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-SSC-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DDI-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-9824272:r:Somitogenesis", "R-SSC-69541:r:Stabilization of p53", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-9020591:r:Interleukin-12 signaling", "R-RNO-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-CEL-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-8849474:r:PTK6 Activates STAT3", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-BTA-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-CEL-877312:r:Regulation of IFNG signaling", "R-DME-186763:r:Downstream signal transduction", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8875791:r:MET activates STAT3", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-BTA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-8941333:r:RUNX2 regulates genes involved in differentiation of myeloid cells", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-RNO-6811555:r:PI5P Regulates TP53 Acetylation", "R-SSC-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-BTA-1251985:r:Nuclear signaling by ERBB4", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-SSC-186763:r:Downstream signal transduction", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-BTA-8854691:r:Interleukin-20 family signaling", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-8849474:r:PTK6 Activates STAT3", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-HSA-844456:r:The NLRP3 inflammasome", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-SSC-6783783:r:Interleukin-10 signaling", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-CEL-8854691:r:Interleukin-20 family signaling", "R-DRE-9833482:r:PKR-mediated signaling", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-SSC-8941855:r:RUNX3 regulates CDKN1A transcription", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-SSC-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-CEL-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9020591:r:Interleukin-12 signaling", "R-SSC-9008059:r:Interleukin-37 signaling", "R-SSC-69473:r:G2/M DNA damage checkpoint", "R-RNO-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-CEL-8941326:r:RUNX2 regulates bone development", "R-RNO-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-RNO-982772:r:Growth hormone receptor signaling", "R-DME-877312:r:Regulation of IFNG signaling", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-6783783:r:Interleukin-10 signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-CEL-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-CEL-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-877300:r:Interferon gamma signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-8984722:r:Interleukin-35 Signalling", "R-DME-209405:r:JAK/STAT pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-69481:r:G2/M Checkpoints", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-SSC-8983432:r:Interleukin-15 signaling", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-DDI-8854691:r:Interleukin-20 family signaling", "R-BTA-9020558:r:Interleukin-2 signaling", "R-CEL-9008059:r:Interleukin-37 signaling", "R-DME-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-9723905:r:Loss of function of TP53 in cancer due to loss of tetramerization ability", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9609690:r:HCMV Early Events", "R-BTA-8983432:r:Interleukin-15 signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-SSC-2559580:r:Oxidative Stress Induced Senescence", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-BTA-9833482:r:PKR-mediated signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-DME-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DRE-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-8940973:r:RUNX2 regulates osteoblast differentiation", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-69541:r:Stabilization of p53", "R-BTA-1266695:r:Interleukin-7 signaling", "R-HSA-9832991:r:Formation of the posterior neural plate", "R-CEL-8983432:r:Interleukin-15 signaling", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-MMU-8941855:r:RUNX3 regulates CDKN1A transcription", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-SSC-1059683:r:Interleukin-6 signaling", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-8875791:r:MET activates STAT3", "R-HSA-70635:r:Urea cycle", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-DDI-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-8985947:r:Interleukin-9 signaling", "R-DDI-9008059:r:Interleukin-37 signaling", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-209560:r:NF-kB is activated and signals survival", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-DRE-69541:r:Stabilization of p53", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-RNO-448706:r:Interleukin-1 processing", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9020558:r:Interleukin-2 signaling", "R-SSC-69481:r:G2/M Checkpoints", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-209400:r:Transcriptional activtion by phosphorylated DL/DIF dimer", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-DRE-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-982772:r:Growth hormone receptor signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-RNO-8877330:r:RUNX1 and FOXP3 control the development of 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"R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DME-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DRE-6804760:r:Regulation of TP53 Activity through Methylation", "R-BTA-8985947:r:Interleukin-9 signaling", "R-DME-350054:r:Notch-HLH transcription pathway", "R-BTA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-SSC-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-CEL-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-MMU-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-HSA-5620971:r:Pyroptosis", "R-CEL-8951671:r:RUNX3 regulates 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signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9020933:r:Interleukin-23 signaling", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-9020591:r:Interleukin-12 signaling", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-9008059:r:Interleukin-37 signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-MMU-6804754:r:Regulation of TP53 Expression", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-DME-549127:r:SLC-mediated transport of organic cations", "R-RNO-1059683:r:Interleukin-6 signaling", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-186763:r:Downstream signal transduction", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-SSC-8985947:r:Interleukin-9 signaling", "R-HSA-5578768:r:Physiological factors", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DDI-877300:r:Interferon gamma signaling", "R-CEL-8985947:r:Interleukin-9 signaling", "R-DDI-9020956:r:Interleukin-27 signaling", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-8875791:r:MET activates STAT3", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-9645135:r:STAT5 Activation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-RNO-8985947:r:Interleukin-9 signaling", "R-DDI-1059683:r:Interleukin-6 signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-CEL-8984722:r:Interleukin-35 Signalling", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-69541:r:Stabilization of p53", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-DDI-8983432:r:Interleukin-15 signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-4086398:r:Ca2+ pathway", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9701898:r:STAT3 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"R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-SSC-5689896:r:Ovarian tumor domain proteases", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DRE-6804754:r:Regulation of TP53 Expression", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-CEL-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-8951911:r:RUNX3 regulates RUNX1-mediated transcription", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-SSC-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-DDI-8985947:r:Interleukin-9 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-8951430:r:RUNX3 regulates WNT signaling", "R-DME-210671:r:Transcriptional repression by nuclear factors", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DME-8983432:r:Interleukin-15 signaling", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-CEL-8878166:r:Transcriptional regulation by RUNX2", "R-CEL-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-201556:r:Signaling by ALK", "R-DME-8941326:r:RUNX2 regulates bone development", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-6783783:r:Interleukin-10 signaling", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9020933:r:Interleukin-23 signaling", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-69541:r:Stabilization of p53", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-6804754:r:Regulation of TP53 Expression", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-9008059:r:Interleukin-37 signaling", "R-HSA-9823730:r:Formation of definitive endoderm", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-9796292:r:Formation of axial mesoderm", "R-DRE-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-DME-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-RNO-201556:r:Signaling by ALK", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-DME-9020933:r:Interleukin-23 signaling", "R-RNO-6804754:r:Regulation of TP53 Expression", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CEL-9833482:r:PKR-mediated signaling", "R-DME-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-SSC-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-DME-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-SSC-6811555:r:PI5P Regulates TP53 Acetylation", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-DME-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DRE-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-SSC-9020958:r:Interleukin-21 signaling", "R-SSC-6804754:r:Regulation of TP53 Expression", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-9020956:r:Interleukin-27 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-DME-8951430:r:RUNX3 regulates WNT signaling", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-1059683:r:Interleukin-6 signaling", "R-SSC-6804757:r:Regulation of TP53 Degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-SSC-9020956:r:Interleukin-27 signaling", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-9008059:r:Interleukin-37 signaling", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DDI-6783783:r:Interleukin-10 signaling", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-DME-9020591:r:Interleukin-12 signaling", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SSC-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-DME-201556:r:Signaling by ALK", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-RNO-186763:r:Downstream signal transduction", "R-RNO-549127:r:SLC-mediated transport of organic cations"], "type": "Homologous_superfamily"}, "IPR008969": {"description": "Carboxypeptidase-like, regulatory domain superfamily", "go_ids": [], "go_terms": [], "name": "CarboxyPept-like_regulatory", "pathway_ids": ["R-MMU-163125", "R-HSA-2404192", "R-MMU-977606", "R-HSA-977606", "R-HSA-264876", "R-MMU-432722", "R-RNO-9696264", "R-RNO-977606", "R-MMU-9696264", "R-MMU-9696273", "R-HSA-432722", "R-RNO-9696273", "R-RNO-432722", "R-HSA-9696273", "R-HSA-9696264", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-264876:r:Insulin processing", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9696264:r:RND3 GTPase cycle", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Homologous_superfamily"}, "IPR008971": {"description": "HSP40/DnaJ peptide-binding", "go_ids": ["GO:0006457"], "go_terms": ["GO:0006457:protein folding:P"], "name": "HSP40/DnaJ_pept-bd", 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"R-BTA-3371568:r:Attenuation phase", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-SCE-3371568:r:Attenuation phase", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DDI-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-3371568:r:Attenuation phase", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-3371568:r:Attenuation phase", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Homologous_superfamily"}, "IPR008972": {"description": "Cupredoxin", "go_ids": [], "go_terms": [], "name": "Cupredoxin", "pathway_ids": ["R-BTA-2682334", "R-HSA-6798695", "R-MMU-204005", 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"R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-9672387:r:Defective F8 accelerates dissociation of the A2 domain", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-HSA-425410:r:Metal ion SLC transporters", "R-MMU-9864848:r:Complex IV assembly", "R-GGA-611105:r:Respiratory electron transport", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9672395:r:Defective F8 binding to the cell membrane", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-5619060:r:Defective CP causes aceruloplasminemia (ACERULOP)", "R-HSA-9638482:r:Metal ion assimilation from the host", 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HMOX1", "R-HSA-5619049:r:Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9672383:r:Defective factor IX causes thrombophilia", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-HSA-9674519:r:Defective F8 sulfation at Y1699", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-GGA-9864848:r:Complex IV assembly", "R-DRE-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-114608:r:Platelet degranulation", "R-GGA-5419276:r:Mitochondrial translation termination", "R-MMU-917937:r:Iron uptake and transport", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-8957275:r:Post-translational protein phosphorylation", 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"R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SSC-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-SSC-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-BTA-193692:r:Regulated proteolysis of p75NTR", "R-XTR-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-3371378:r:Regulation by c-FLIP", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-XTR-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DRE-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-SSC-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-XTR-5632684:r:Hedgehog 'on' state", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-DDI-975163:r:IRAK2 mediated activation of 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"R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-202424:r:Downstream TCR signaling", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Homologous_superfamily"}, "IPR008977": {"description": "PHM/PNGase F domain superfamily", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": 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"R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-3371511:r:HSF1 activation", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-SCE-8939211:r:ESR-mediated signaling", "R-SPO-3371511:r:HSF1 activation", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-9696270:r:RND2 GTPase cycle", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-844456:r:The NLRP3 inflammasome", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-SCE-3371511:r:HSF1 activation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a 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"R-HSA-69017", "R-MMU-3928662", "R-DRE-3928665", "R-HSA-8957275", "R-DDI-174154", "R-CEL-3928664", "R-HSA-9013418", "R-HSA-9672396", "R-HSA-264876", "R-MMU-9861718", "R-HSA-9672397", "R-HSA-9918485", "R-MMU-9013408", "R-MMU-174154", "R-MMU-69017", "R-DME-176407", "R-HSA-5693565", "R-MMU-110381", "R-DDI-179409", "R-MMU-422085", "R-MMU-9013420", "R-DME-2467813", "R-HSA-2682334", "R-DDI-176407", "R-MMU-1566948", "R-HSA-447038", "R-HSA-209952", "R-MMU-174084", "R-MMU-68867", "R-DME-2559582", "R-HSA-5620924", "R-DME-174048", "R-RNO-445144", "R-DME-141430", "R-HSA-69473", "R-MMU-163841", "R-HSA-2022857", "R-MMU-2559582", "R-HSA-422085", "R-HSA-447041", "R-HSA-9696264", "R-RNO-2160916", "R-MMU-9013423", "R-RNO-5173214", "R-HSA-110381", "R-HSA-8853383", "R-RNO-8951664", "R-RNO-9696264", "R-MMU-2024101", "R-HSA-445144", "R-DDI-2022857", "R-HSA-174048", "R-SCE-2173796", "R-HSA-9768727", "R-MMU-9768727", "R-MMU-186797", "R-RNO-6798695", "R-RNO-2173796", "R-DME-69017", "R-DME-983168", "R-SPO-2173796", "R-HSA-2467813", "R-HSA-9662834", "R-HSA-9674519", "R-DME-6799198", "R-MMU-179409", "R-HSA-2206292", "R-HSA-373760", "R-RNO-110381", "R-HSA-9861718", "R-HSA-9013423", "R-HSA-1181150", "R-DDI-2467813", "R-MMU-532668", "R-DDI-176412", "R-MMU-167060", "R-SPO-9013420", "R-HSA-1442490", "R-MMU-3928664", "R-CEL-9013423", "R-MMU-5693607", "R-HSA-176412", "R-MMU-176408", "R-HSA-381038", "R-RNO-1592389", "R-RNO-2682334", "R-HSA-376176", "R-DME-176412", "R-CEL-3928665", "R-MMU-140875", "R-HSA-5693571", "R-DDI-174184", "R-RNO-399955", "R-DME-174178", "R-CEL-9013420", "R-DME-2173796", "R-DDI-2024101", "R-MMU-9013149", "R-CEL-186797", "R-HSA-9927426", "R-DME-186797", "R-BTA-983168", "R-SSC-2160916", "R-MMU-204005", "R-HSA-9013422", "R-DRE-399954", "R-HSA-5696397", "R-DRE-194306", "R-MMU-9639288", "R-CEL-9013424", "R-HSA-9013424", "R-MMU-9013404", "R-MMU-8957275", "R-HSA-3928662", "R-HSA-141430", "R-MMU-9013422", "R-RNO-9013424", "R-SPO-9696273", "R-DDI-2559582", "R-HSA-9926550", "R-HSA-5210891", "R-HSA-176408", "R-HSA-381426", "R-HSA-2173789", "R-RNO-3000171", "R-HSA-9672393", "R-MMU-5620924", "R-HSA-68867", "R-HSA-2024101", "R-HSA-176409", "R-DME-174154", "R-MMU-140837", "R-DME-179409", "R-MMU-445144", "R-RNO-9696273", "R-MMU-2160916", "R-HSA-163841", "R-HSA-9013404", "R-HSA-9013149", "R-MMU-141430", "R-RNO-532668", "R-HSA-167060", "R-SPO-9013424", "R-HSA-418890", "R-MMU-6782210", "R-HSA-376172", "R-RNO-983168", "R-MMU-399956", "R-DDI-9840310", "R-HSA-8853884", "R-BTA-8951664", "R-SPO-176408", "R-RNO-9696270", "R-HSA-418886", "R-HSA-418885", "R-HSA-2559582", "R-HSA-174184", "R-HSA-5649702", "R-MMU-9953170", "R-CEL-9013149", "R-MMU-209952", "R-MMU-174048", "R-DME-8963889", "R-RNO-8957275", "R-SPO-983168", "R-SSC-2024101", "R-HSA-381771", "R-HSA-2173796", "R-DRE-2682334", "R-RNO-9953170", "R-HSA-9013420", "R-HSA-390471", "R-HSA-5083635", "R-HSA-428542", "R-MMU-8963889", "R-MMU-2682334", "R-MMU-3928663", "R-HSA-9679191", "R-HSA-1592389", "R-DME-532668", "R-MMU-176407", "R-DDI-983168", "R-RNO-167060", "R-MMU-983168", "R-HSA-4341670", "R-HSA-2892247", "R-MMU-9696270", "R-DDI-174178", "R-MMU-1442490", "R-RNO-9861718", "R-CEL-3000171", "R-DRE-3928663", "R-HSA-2206308"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-DME-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8951664:r:Neddylation", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-6799198:r:Complex I biogenesis", "R-HSA-9673202:r:Defective F9 variant does not activate FX", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-CEL-1566948:r:Elastic fibre formation", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-3928664:r:Ephrin signaling", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9672387:r:Defective F8 accelerates dissociation of the A2 domain", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-9672395:r:Defective F8 binding to the cell membrane", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-373752:r:Netrin-1 signaling", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-DME-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-9757110:r:Prednisone ADME", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-114608:r:Platelet degranulation", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-4085001:r:Sialic acid metabolism", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-2022857:r:Keratan sulfate degradation", "R-RNO-209952:r:Peptide hormone biosynthesis", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-CEL-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9953170:r:GBP-mediated host defense", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-171286:r:Synthesis and processing of ENV and VPU", "R-MMU-5694530:r:Cargo concentration in the ER", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-5694530:r:Cargo concentration in the ER", "R-MMU-8951664:r:Neddylation", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-4085001:r:Sialic acid metabolism", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-9953111:r:MPS IV - Morquio syndrome B (CS/DS degradation)", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-MMU-6799198:r:Complex I biogenesis", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9694614:r:Attachment and Entry", "R-RNO-1566948:r:Elastic fibre formation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9672383:r:Defective factor IX causes thrombophilia", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-1566948:r:Elastic fibre formation", "R-DDI-9754706:r:Atorvastatin ADME", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-2024101:r:CS/DS degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-1442490:r:Collagen degradation", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9953080:r:MPS VII - Sly syndrome (CS/DS degradation)", "R-DDI-159418:r:Recycling of bile acids and salts", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-3928664:r:Ephrin signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-HSA-264876:r:Insulin processing", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9672397:r:Defective F8 secretion", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-447038:r:NrCAM interactions", "R-HSA-209952:r:Peptide hormone biosynthesis", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-5620924:r:Intraflagellar transport", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-RNO-445144:r:Signal transduction by L1", "R-DME-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-HSA-2022857:r:Keratan sulfate degradation", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-447041:r:CHL1 interactions", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-2160916:r:Hyaluronan degradation", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-8951664:r:Neddylation", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-445144:r:Signal transduction by L1", "R-DDI-2022857:r:Keratan sulfate degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SCE-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-9674519:r:Defective F8 sulfation at Y1699", "R-DME-6799198:r:Complex I biogenesis", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2206292:r:MPS VII - Sly syndrome (Hyaluronan metabolism)", "R-HSA-373760:r:L1CAM interactions", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-1181150:r:Signaling by NODAL", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-MMU-167060:r:NGF processing", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-1442490:r:Collagen degradation", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-HSA-376176:r:Signaling by ROBO receptors", "R-DME-176412:r:Phosphorylation of the APC/C", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-9013420:r:RHOU GTPase cycle", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DDI-2024101:r:CS/DS degradation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-186797:r:Signaling by PDGF", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-DME-186797:r:Signaling by PDGF", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-2160916:r:Hyaluronan degradation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-CEL-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-445144:r:Signal transduction by L1", "R-RNO-9696273:r:RND1 GTPase cycle", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-167060:r:NGF processing", "R-SPO-9013424:r:RHOV GTPase cycle", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-376172:r:DSCAM interactions", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-BTA-8951664:r:Neddylation", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-9953170:r:GBP-mediated host defense", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-209952:r:Peptide hormone biosynthesis", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-2024101:r:CS/DS degradation", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-RNO-9953170:r:GBP-mediated host defense", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-167060:r:NGF processing", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-4341670:r:Defective NEU1 causes sialidosis", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-1442490:r:Collagen degradation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-2206308:r:MPS IV - Morquio syndrome B (Keratin metabolism)"], "type": "Homologous_superfamily"}, "IPR008980": {"description": "Viral capsid/haemagglutinin protein", "go_ids": ["GO:0019031", "GO:0019064", "GO:0046789"], "go_terms": ["GO:0019031:viral envelope:C", "GO:0019064:fusion of virus membrane with host plasma membrane:P", "GO:0046789:host cell surface receptor binding:F"], "name": "Capsid_hemagglutn", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168288", "R-HSA-168275", "R-HSA-168316", "R-HSA-198933", "R-HSA-168298", "R-HSA-168874", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-168298:r:Release", "R-HSA-168874:r:Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Homologous_superfamily"}, "IPR008981": {"description": "F-MuLV receptor-binding", "go_ids": [], "go_terms": [], "name": "FMuLV_rcpt-bd", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR008982": {"description": "Adenovirus pIV-like, attachment domain", "go_ids": ["GO:0019062", "GO:0007155", "GO:0019058"], "go_terms": ["GO:0019062:virion attachment to host cell:P", "GO:0007155:cell adhesion:P", "GO:0019058:viral life cycle:P"], "name": "Adenovirus_pIV-like_att", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR008983": {"description": "Tumour necrosis factor-like domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Tumour_necrosis_fac-like_dom", "pathway_ids": ["R-MMU-9856649", "R-HSA-173623", "R-HSA-5218900", "R-HSA-9942503", "R-HSA-5626978", "R-HSA-9920588", "R-RNO-5668541", "R-SSC-5357786", "R-HSA-8951664", "R-HSA-5669034", "R-BTA-5668541", "R-RNO-5357905", "R-SSC-5669034", "R-CFA-198933", "R-HSA-75893", "R-SSC-5357905", "R-DDI-114608", "R-HSA-1650814", "R-HSA-9841922", "R-RNO-977606", "R-CFA-5676594", "R-MMU-8951664", "R-MMU-3000171", "R-RNO-5626978", "R-MMU-5668541", "R-HSA-8948216", "R-RNO-173623", "R-MMU-3371378", "R-HSA-166663", "R-HSA-6783783", "R-HSA-9614657", "R-RNO-5676594", "R-MMU-163680", "R-BTA-977606", "R-MMU-75893", "R-MMU-2129379", "R-DDI-6798695", "R-RNO-198933", "R-HSA-3000171", "R-CFA-5357786", "R-HSA-450520", "R-MMU-450520", "R-HSA-6785807", "R-DME-450520", "R-HSA-5357786", "R-HSA-75158", "R-SSC-5676594", "R-HSA-69416", "R-HSA-5173105", "R-MMU-69416", "R-MMU-198933", "R-HSA-2022090", "R-MMU-5357905", "R-MMU-216083", "R-HSA-198933", "R-DDI-434313", "R-MMU-5669034", "R-HSA-3371378", "R-MMU-75158", "R-BTA-173623", "R-RNO-5669034", "R-MMU-114608", "R-SSC-75893", "R-DRE-114608", "R-MMU-5676594", "R-CFA-5668541", "R-MMU-8948216", "R-HSA-5676594", "R-RNO-75157", "R-HSA-8862803", "R-BTA-5676594", "R-MMU-5357956", "R-MMU-75157", "R-MMU-173623", "R-HSA-114608", "R-HSA-5357905", "R-HSA-977606", "R-DRE-2129379", "R-RNO-75893", "R-MMU-5218900", "R-RNO-3371378", "R-MMU-5626978", "R-CFA-5357956", "R-HSA-1442490", "R-SSC-5668541", "R-MMU-5357786", "R-MMU-977606", "R-DRE-5173105", "R-HSA-216083", "R-BTA-5669034", "R-HSA-2129379", "R-RNO-9856649", "R-HSA-381340", "R-SSC-5357956", "R-CFA-75893", "R-MMU-2022090", "R-RNO-69416", "R-SSC-5626978", "R-HSA-5668541", "R-HSA-5213460", "R-RNO-5218900", "R-CFA-5669034", "R-HSA-5357956", "R-MMU-1650814", "R-HSA-75157", "R-RNO-5357956", "R-CFA-5626978", "R-HSA-9856649", "R-HSA-140534", "R-RNO-5357786", "R-CFA-5357905", "R-MMU-1442490", "R-MMU-5173105", "R-HSA-163680"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-SSC-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-8951664:r:Neddylation", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-SSC-5669034:r:TNFs bind their physiological receptors", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-75893:r:TNF signaling", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-DDI-114608:r:Platelet degranulation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-977606:r:Regulation of Complement cascade", "R-CFA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-8951664:r:Neddylation", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-8948216:r:Collagen chain trimerization", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-MMU-3371378:r:Regulation by c-FLIP", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-RNO-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-75893:r:TNF signaling", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-CFA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-75158:r:TRAIL signaling", "R-SSC-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-69416:r:Dimerization of procaspase-8", "R-HSA-5173105:r:O-linked glycosylation", "R-MMU-69416:r:Dimerization of procaspase-8", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DDI-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-HSA-3371378:r:Regulation by c-FLIP", "R-MMU-75158:r:TRAIL signaling", "R-BTA-173623:r:Classical antibody-mediated complement activation", "R-RNO-5669034:r:TNFs bind their physiological receptors", "R-MMU-114608:r:Platelet degranulation", "R-SSC-75893:r:TNF signaling", "R-DRE-114608:r:Platelet degranulation", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-8948216:r:Collagen chain trimerization", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-RNO-75157:r:FasL/ CD95L signaling", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-BTA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-75157:r:FasL/ CD95L signaling", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-977606:r:Regulation of Complement cascade", "R-DRE-2129379:r:Molecules associated with elastic fibres", "R-RNO-75893:r:TNF signaling", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-RNO-3371378:r:Regulation by c-FLIP", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-1442490:r:Collagen degradation", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-977606:r:Regulation of Complement cascade", "R-DRE-5173105:r:O-linked glycosylation", "R-HSA-216083:r:Integrin cell surface interactions", "R-BTA-5669034:r:TNFs bind their physiological receptors", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CFA-75893:r:TNF signaling", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-69416:r:Dimerization of procaspase-8", "R-SSC-5626978:r:TNFR1-mediated ceramide production", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-5218900:r:CASP8 activity is inhibited", "R-CFA-5669034:r:TNFs bind their physiological receptors", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-75157:r:FasL/ CD95L signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CFA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-1442490:r:Collagen degradation", "R-MMU-5173105:r:O-linked glycosylation", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity"], "type": "Homologous_superfamily"}, "IPR008984": {"description": "SMAD/FHA domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "SMAD_FHA_dom_sf", "pathway_ids": ["R-HSA-9701192", "R-MMU-936964", "R-MMU-1502540", "R-MMU-3214847", "R-GGA-975110", "R-MMU-2173789", "R-HSA-9839394", "R-HSA-9770562", "R-HSA-9696270", "R-SSC-933541", "R-SSC-9617828", "R-DRE-2173788", "R-HSA-9709603", "R-DME-2173795", "R-SPO-5693565", "R-HSA-5685939", "R-CEL-201451", "R-DDI-5675221", "R-CEL-5693565", "R-RNO-5685942", "R-GGA-5689880", "R-BTA-9645460", "R-HSA-9725371", "R-HSA-933541", "R-DME-1181150", "R-DRE-1502540", "R-HSA-3214847", "R-MMU-9696273", "R-HSA-2173788", "R-SSC-201451", "R-DME-5689880", "R-SSC-2173788", "R-MMU-8941326", "R-HSA-5693616", "R-BTA-918233", "R-HSA-6796648", "R-HSA-936964", "R-DDI-5693565", "R-DDI-5675482", "R-HSA-5693607", "R-MMU-445989", "R-HSA-6804757", "R-BTA-5693607", "R-CEL-2173795", "R-RNO-5693579", "R-MMU-2559586", "R-CEL-2173796", "R-RNO-5693607", "R-MMU-3134973", "R-HSA-1502540", "R-RNO-69473", "R-RNO-8941855", "R-HSA-3315487", "R-HSA-9860276", "R-HSA-9013695", "R-DRE-69473", "R-BTA-168928", "R-SPO-75035", "R-DRE-5693565", "R-HSA-975110", "R-HSA-3134973", "R-MMU-2173788", "R-BTA-1169408", "R-MMU-5693571", "R-MMU-933541", "R-BTA-69473", "R-HSA-3108214", "R-HSA-9704646", "R-DDI-69473", "R-CEL-1502540", "R-RNO-2173788", "R-SSC-2173789", "R-DME-9617828", "R-HSA-8952158", "R-HSA-918233", "R-SSC-8941855", "R-DRE-2559586", "R-GGA-351444", "R-RNO-201451", "R-HSA-5685938", "R-MMU-168928", "R-HSA-9013973", "R-DDI-3295583", "R-MMU-5693548", "R-HSA-69601", "R-CEL-8941326", "R-MMU-1169408", "R-BTA-933541", "R-HSA-9824585", "R-SSC-168928", "R-HSA-983189", "R-HSA-9692916", "R-HSA-69541", "R-SPO-69601", "R-DME-69541", "R-DRE-5685938", "R-MMU-2173795", "R-CEL-1181150", "R-HSA-5689880", "R-DME-2173788", "R-DDI-6804760", "R-RNO-5693565", "R-HSA-5693565", "R-HSA-3311021", "R-MMU-3134963", "R-DRE-5693571", "R-HSA-6811434", "R-DDI-5213460", "R-SSC-1169408", "R-DDI-5673000", "R-BTA-936964", "R-MMU-6804760", "R-CEL-2173788", "R-HSA-69473", "R-MMU-72163", "R-SCE-69473", "R-HSA-6804760", "R-RNO-5693571", "R-MMU-9860276", "R-RNO-5689880", "R-DRE-5693548", "R-SSC-9013973", "R-RNO-5693568", "R-HSA-5696394", "R-DME-69601", "R-DRE-5693616", "R-RNO-1502540", "R-DME-201451", "R-RNO-2173796", "R-MMU-1606341", "R-SSC-3134973", "R-HSA-5625900", "R-HSA-9705671", "R-HSA-5685942", "R-DME-1502540", "R-HSA-168928", "R-HSA-9772755", "R-SSC-2173795", "R-BTA-201451", "R-MMU-983189", "R-DRE-5685939", "R-HSA-1181150", "R-RNO-5685938", "R-MMU-9772755", "R-GGA-351442", "R-HSA-8941326", "R-HSA-5693568", "R-SCE-3232118", "R-MMU-8941855", "R-MMU-5693607", "R-CEL-69473", "R-GGA-9013973", "R-MMU-6804757", "R-HSA-3304356", "R-XTR-9645460", "R-CEL-5689880", "R-SCE-9018519", "R-HSA-9754189", "R-HSA-5693571", "R-RNO-1181150", "R-HSA-877300", "R-HSA-9733709", "R-DME-8941326", "R-BTA-5693571", "R-DME-2173796", "R-DME-75035", "R-HSA-5693579", "R-SSC-8941326", "R-SCE-75035", "R-HSA-1606341", "R-GGA-8941855", "R-RNO-983189", "R-MMU-5693616", "R-MMU-69541", "R-DRE-5693568", "R-RNO-2173795", "R-HSA-9709570", "R-MMU-918233", "R-HSA-9823730", "R-SSC-918233", "R-HSA-8941855", "R-SSC-1502540", "R-HSA-9796292", "R-GGA-2173795", "R-GGA-434136", "R-DRE-2173789", "R-MMU-5693568", "R-SPO-5685939", "R-HSA-2173789", "R-BTA-1606341", "R-DRE-6804756", "R-GGA-2173796", "R-DME-69473", "R-DRE-5685942", "R-HSA-6785807", "R-HSA-9704331", "R-HSA-3134975", "R-RNO-445989", "R-HSA-5689603", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-HSA-2559586", "R-HSA-445989", "R-SSC-1181150", "R-GGA-2173789", "R-CEL-75035", "R-RNO-418990", "R-HSA-936440", "R-MMU-9013973", "R-HSA-1169408", "R-HSA-5649702", "R-MMU-69601", "R-SSC-3134975", "R-SCE-5693565", "R-HSA-9615017", "R-GGA-1181150", "R-BTA-3270619", "R-DDI-75035", "R-SSC-5689880", "R-RNO-6804756", "R-MMU-5689603", "R-HSA-2173796", "R-GGA-2173788", "R-DRE-5689880", "R-RNO-2559586", "R-RNO-6811434", "R-HSA-390471", "R-SSC-1606341", "R-BTA-8941326", "R-MMU-5685942", "R-HSA-9645460", "R-MMU-418990", "R-CEL-69601", "R-SPO-2559586", "R-SSC-936440", "R-MMU-936440", "R-RNO-9617828", "R-SPO-5693548", "R-MMU-9696270", "R-HSA-9696273", "R-DME-2173789", "R-BTA-5689880", "R-HSA-6802952", "R-MMU-9770562", "R-GGA-351433", "R-CEL-6804760", "R-RNO-5685939", "R-RNO-72163", "R-MMU-6804756", "R-MMU-75035", "R-GGA-9617828", "R-HSA-9617828", "R-DRE-2173795", "R-MMU-5685938", "R-MMU-69473", "R-MMU-5689880", "R-HSA-418990", "R-HSA-3134963", "R-HSA-9844594", "R-DME-8941855", "R-SSC-2173796", "R-MMU-975110", "R-MMU-909733", "R-MMU-5696394", "R-DRE-201451", "R-DRE-5693579", "R-MMU-6811434", "R-HSA-3270619", "R-MMU-3270619", "R-GGA-217106", "R-MMU-5625900", "R-MMU-2173796", "R-MMU-3134975", "R-BTA-3134973", "R-GGA-3134963", "R-HSA-452723", "R-BTA-5693565", "R-BTA-9013973", "R-DME-6804756", "R-HSA-9008059", "R-HSA-72163", "R-HSA-6804756", "R-DDI-5674135", "R-HSA-909733", "R-MMU-3108214", "R-CEL-2173789", "R-MMU-1181150", "R-GGA-433819", "R-HSA-9833109", "R-CEL-9617828", "R-DRE-5693607", "R-GGA-933541", "R-MMU-5649702", "R-SSC-936964", "R-SCE-69601", "R-SSC-3270619", "R-HSA-9735871", "R-MMU-9645460", "R-HSA-201451", "R-GGA-1502540", "R-DME-5693565", "R-SPO-69473", "R-RNO-5693548", "R-HSA-3656532", "R-MMU-5693565", "R-HSA-75035", "R-BTA-936440", "R-RNO-9645460", "R-DDI-69601", "R-BTA-445989", "R-HSA-2173795", "R-HSA-912446", "R-MMU-201451", "R-CEL-8941855", "R-MMU-5685939", "R-GGA-1227882", "R-MMU-5693579", "R-GGA-936964", "R-RNO-2173789", "R-MMU-9617828"], "pathways": ["R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-1502540:r:Signaling by Activin", "R-MMU-3214847:r:HATs acetylate histones", "R-GGA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SSC-933541:r:TRAF6 mediated IRF7 activation", "R-SSC-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-CEL-201451:r:Signaling by BMP", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-5689880:r:Ub-specific processing proteases", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-DME-1181150:r:Signaling by NODAL", "R-DRE-1502540:r:Signaling by Activin", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SSC-201451:r:Signaling by BMP", "R-DME-5689880:r:Ub-specific processing proteases", "R-SSC-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-8941326:r:RUNX2 regulates bone development", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-1502540:r:Signaling by Activin", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-3315487:r:SMAD2/3 MH2 Domain Mutants in Cancer", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-BTA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SPO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-DDI-69473:r:G2/M DNA damage checkpoint", "R-CEL-1502540:r:Signaling by Activin", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SSC-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-SSC-8941855:r:RUNX3 regulates CDKN1A transcription", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-RNO-201451:r:Signaling by BMP", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-DDI-3295583:r:TRP channels", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-8941326:r:RUNX2 regulates bone development", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-BTA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-SSC-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-983189:r:Kinesins", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-69541:r:Stabilization of p53", "R-SPO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-69541:r:Stabilization of p53", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-1181150:r:Signaling by NODAL", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DDI-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-3311021:r:SMAD4 MH2 Domain Mutants in Cancer", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-DDI-5673000:r:RAF activation", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-SCE-69473:r:G2/M DNA damage checkpoint", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-5693548:r:Sensing of DNA Double Strand Breaks", "R-SSC-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-1502540:r:Signaling by Activin", "R-DME-201451:r:Signaling by BMP", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-1606341:r:IRF3 mediated activation of type 1 IFN", "R-SSC-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-DME-1502540:r:Signaling by Activin", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-SSC-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-201451:r:Signaling by BMP", "R-MMU-983189:r:Kinesins", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-1181150:r:Signaling by NODAL", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-MMU-8941855:r:RUNX3 regulates CDKN1A transcription", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-CEL-69473:r:G2/M DNA damage checkpoint", "R-GGA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-XTR-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CEL-5689880:r:Ub-specific processing proteases", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-1181150:r:Signaling by NODAL", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9733709:r:Cardiogenesis", "R-DME-8941326:r:RUNX2 regulates bone development", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SSC-8941326:r:RUNX2 regulates bone development", "R-SCE-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-GGA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-983189:r:Kinesins", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-69541:r:Stabilization of p53", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-MMU-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9823730:r:Formation of definitive endoderm", "R-SSC-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-SSC-1502540:r:Signaling by Activin", "R-HSA-9796292:r:Formation of axial mesoderm", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-GGA-434136:r:Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1", "R-DRE-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-5693568:r:Resolution 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"R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-912446:r:Meiotic recombination", "R-MMU-201451:r:Signaling by BMP", "R-CEL-8941855:r:RUNX3 regulates CDKN1A transcription", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9617828:r:FOXO-mediated transcription of cell cycle genes"], "type": "Homologous_superfamily"}, "IPR008986": {"description": "EV matrix protein", "go_ids": [], "go_terms": [], "name": "EV_matrix", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR008987": {"description": 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"R-HSA-166665:r:Terminal pathway of complement", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-HSA-9694614:r:Attachment and Entry", "R-CEL-114608:r:Platelet degranulation", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-174577:r:Activation of C3 and C5", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-173736:r:Alternative complement activation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-173736:r:Alternative complement activation", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-CFA-9839383:r:TGFBR3 PTM regulation", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-376172:r:DSCAM interactions", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation", "R-RNO-166663:r:Initial triggering of complement", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2024096:r:HS-GAG degradation", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-525793:r:Myogenesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-GGA-114608:r:Platelet degranulation", "R-BTA-174577:r:Activation of C3 and C5", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-166665:r:Terminal pathway of complement", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-RNO-173736:r:Alternative complement activation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-CFA-6798695:r:Neutrophil degranulation", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Homologous_superfamily"}, "IPR008995": {"description": "Molybdate/tungstate binding, C-terminal", "go_ids": [], "go_terms": [], "name": "Mo/tungstate-bd_C_term_dom", "pathway_ids": ["R-MTU-936635"], "pathways": ["R-MTU-936635:r:Sulfate assimilation"], "type": "Homologous_superfamily"}, "IPR008996": {"description": "Cytokine IL1/FGF", "go_ids": [], "go_terms": [], "name": "IL1/FGF", "pathway_ids": ["R-RNO-190322", "R-DRE-5654699", "R-MMU-9839397", "R-HSA-8963889", "R-MMU-5654720", "R-MMU-6811558", "R-BTA-5673001", "R-GGA-5654733", "R-SSC-5654219", "R-SSC-109704", "R-DRE-190372", "R-RNO-190371", "R-GGA-5654695", "R-CEL-5654219", "R-BTA-5654710", "R-MMU-5654221", "R-BTA-5658623", "R-HSA-5654695", "R-BTA-6811558", "R-DRE-5654228", "R-HSA-9834899", "R-SSC-5654228", "R-GGA-5673001", "R-RNO-190374", "R-HSA-3000171", "R-GGA-5654726", "R-CEL-5654726", "R-HSA-9839397", "R-HSA-9008059", "R-HSA-190377", "R-HSA-5654700", "R-MMU-448706", "R-MMU-5654219", "R-RNO-5654228", "R-MMU-5654712", "R-CEL-6811558", "R-BTA-5654689", "R-RNO-5654712", "R-RNO-5654699", "R-MMU-5654227", "R-BTA-3000170", "R-RNO-1257604", "R-HSA-5620971", "R-CEL-5654720", "R-DRE-109704", "R-CEL-5654227", "R-GGA-190375", "R-RNO-5654727", "R-HSA-1839130", "R-SSC-5620971", "R-DRE-5654221", "R-RNO-5654719", "R-CEL-5654712", "R-CEL-5654221", "R-MMU-5654704", "R-MMU-190377", "R-SSC-448706", "R-HSA-2033519", "R-GGA-5654228", "R-HSA-190372", "R-GGA-190322", "R-MMU-5660668", "R-RNO-9839397", "R-BTA-5654699", "R-HSA-5655332", "R-HSA-3000170", "R-SSC-5654712", "R-HSA-5654726", "R-MMU-190322", "R-HSA-109704", "R-GGA-5654700", "R-BTA-5654687", "R-HSA-190322", "R-HSA-190371", "R-MMU-1257604", "R-GGA-5654704", "R-MMU-190371", "R-BTA-190375", "R-RNO-5654689", "R-SSC-5654693", "R-DRE-1257604", "R-MMU-5654727", "R-MMU-5654687", "R-RNO-5654733", "R-MMU-1307965", "R-HSA-9761174", "R-RNO-5654227", "R-RNO-190375", "R-RNO-9020702", "R-DRE-5654689", "R-MMU-9012546", "R-HSA-5654228", "R-HSA-190375", "R-HSA-5654693", "R-DRE-5673001", "R-RNO-190370", "R-CEL-5673001", "R-GGA-190377", "R-BTA-5654700", "R-MMU-5654695", "R-GGA-5654693", "R-CEL-5654732", "R-CEL-5654700", "R-MMU-381426", "R-CEL-5654228", "R-HSA-210747", "R-DRE-5654726", "R-HSA-9007892", "R-HSA-5654221", "R-RNO-5673001", "R-GGA-5654720", "R-RNO-190377", "R-HSA-75102", "R-SSC-5654719", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-381426", "R-DRE-5654704", "R-HSA-9012546", "R-BTA-190371", "R-HSA-1257604", "R-DRE-5654700", "R-MMU-5654710", "R-BTA-5654726", "R-BTA-5654227", "R-SSC-1257604", "R-HSA-5654687", "R-BTA-5654720", "R-BTA-5654727", "R-RNO-109704", "R-DRE-5654219", "R-CEL-5654706", "R-BTA-5654733", "R-HSA-5660668", "R-BTA-5654228", "R-MMU-190373", "R-RNO-190372", "R-CEL-5654699", "R-HSA-9938206", "R-CEL-5654710", "R-GGA-1257604", "R-BTA-5654704", "R-RNO-5654706", "R-HSA-1839122", "R-HSA-5654706", "R-HSA-9937080", "R-RNO-5654221", "R-BTA-5654706", "R-GGA-5658623", "R-HSA-5654227", "R-SSC-9960519", "R-GGA-5654732", "R-SSC-5673001", "R-DRE-190375", "R-BTA-9020702", "R-HSA-5654710", "R-MMU-5654733", "R-DRE-5654695", "R-MMU-5620971", "R-RNO-5654700", "R-GGA-190373", "R-HSA-8957275", "R-HSA-77042", "R-GGA-190370", "R-HSA-9020702", "R-BTA-5654719", "R-MMU-9020702", "R-BTA-5654712", "R-HSA-9960519", "R-MMU-3000170", "R-GGA-5654706", "R-CEL-5654695", "R-MMU-5654706", "R-RNO-6811558", "R-DRE-6811558", "R-CEL-1257604", "R-CEL-190373", "R-CEL-3000170", "R-MMU-5673001", "R-GGA-5654689", "R-SSC-190373", "R-MMU-9007892", "R-RNO-5654732", "R-HSA-5654727", "R-HSA-5654689", "R-HSA-9660826", "R-BTA-9839397", "R-MMU-190375", "R-MMU-190372", "R-CEL-5654727", "R-RNO-9012546", "R-HSA-189200", "R-HSA-8851708", "R-BTA-190377", "R-HSA-5654699", "R-RNO-5654688", "R-SSC-5654733", "R-DRE-190371", "R-SSC-5654726", "R-BTA-5654688", "R-HSA-5655253", "R-MMU-5654699", "R-MMU-190374", "R-GGA-190371", "R-GGA-9839397", "R-DRE-190377", "R-BTA-5654695", "R-BTA-5654693", "R-MMU-190370", "R-RNO-5620971", "R-HSA-9832991", "R-CEL-190377", "R-HSA-190374", "R-SSC-5654689", "R-HSA-5654719", "R-SSC-9020702", "R-MMU-109704", "R-DRE-5654227", "R-HSA-5654712", "R-RNO-5660668", "R-HSA-190370", "R-BTA-190370", "R-MMU-5654726", "R-GGA-5654712", "R-CEL-5654733", "R-HSA-5654219", "R-DRE-5654732", "R-BTA-109704", "R-RNO-5654695", "R-CEL-5654689", "R-CEL-5658623", "R-BTA-1257604", "R-MMU-5654693", "R-MMU-5654689", "R-RNO-5654219", "R-RNO-3000170", "R-SSC-190322", "R-BTA-190373", "R-HSA-5654688", "R-RNO-5654726", "R-GGA-5654227", "R-RNO-5654704", "R-RNO-5654710", "R-DRE-5654712", "R-GGA-5654727", "R-BTA-9960525", "R-RNO-448706", "R-BTA-190322", "R-MMU-8957275", "R-SSC-6811558", "R-BTA-9960519", "R-RNO-190373", "R-BTA-5620971", "R-CEL-190370", "R-BTA-9012546", "R-DRE-5654733", "R-MMU-5654732", "R-MMU-5658623", "R-CEL-5654693", "R-HSA-5655302", "R-HSA-6783783", "R-DRE-5654727", "R-GGA-109704", "R-HSA-9690406", "R-GGA-3000170", "R-CEL-190322", "R-DRE-5654720", "R-SSC-5654687", "R-HSA-381426", "R-DRE-5658623", "R-DRE-5654706", "R-SSC-9960525", "R-RNO-5654693", "R-HSA-9830364", "R-CEL-190375", "R-HSA-5654732", "R-HSA-2219530", "R-MMU-5654700", "R-RNO-5658623", "R-HSA-6785807", "R-SSC-5654720", "R-DRE-190373", "R-DRE-5654710", "R-HSA-9014826", "R-HSA-5654720", "R-BTA-190372", "R-MMU-5654688", "R-HSA-5654733", "R-HSA-5654704", "R-GGA-5654687", "R-GGA-5654710", "R-GGA-190372", "R-DRE-190370", "R-HSA-1307965", "R-GGA-5654719", "R-SSC-9012546", "R-MMU-9960525", "R-BTA-448706", "R-HSA-9960525", "R-HSA-2559582", "R-HSA-5576892", "R-DRE-5654687", "R-MMU-189200", "R-HSA-448706", "R-RNO-8957275", "R-MMU-9960519", "R-BTA-5654732", "R-GGA-5654221", "R-MMU-9014826", "R-GGA-6811558", "R-RNO-5654687", "R-MMU-5654228", "R-HSA-5658623", "R-MMU-5654719", "R-DRE-5654693", "R-GGA-5654219", "R-GGA-5654699", "R-HSA-190373", "R-DRE-190322", "R-BTA-5654219", "R-CEL-190372", "R-BTA-5654221", "R-GGA-5654688", "R-RNO-5654720", "R-DRE-5654688", "R-DRE-5654719", "R-HSA-2892247", "R-CEL-190371", "R-SSC-5654688", "R-CEL-3000171", "R-CEL-5654704"], "pathways": ["R-RNO-190322:r:FGFR4 ligand binding and activation", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-SSC-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-SSC-109704:r:PI3K Cascade", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-RNO-190371:r:FGFR3b ligand binding and activation", "R-GGA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-BTA-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9834899:r:Specification of the neural plate border", "R-SSC-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-5654227:r:Phospholipase 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"R-MMU-3000480", "R-RNO-114608", "R-HSA-5578768", "R-RNO-8875513", "R-HSA-918233", "R-MMU-8852405", "R-HSA-977606", "R-MMU-174577", "R-CFA-8957275", "R-HSA-174577", "R-HSA-8851805", "R-BTA-159740", "R-HSA-9694676", "R-HSA-8875791", "R-HSA-9684325", "R-HSA-9733458", "R-HSA-1462054", "R-CFA-9758881", "R-RNO-186797", "R-MMU-9033241", "R-HSA-9754678", "R-SSC-977606", "R-MMU-6806942", "R-CFA-8865999", "R-RNO-375276", "R-HSA-9692916", "R-MMU-8875656", "R-HSA-8957275", "R-MMU-5620971", "R-GGA-159763", "R-HSA-2197563", "R-HSA-9033241", "R-DME-209442", "R-HSA-9672396", "R-RNO-1474228", "R-HSA-9918485", "R-RNO-140875", "R-CFA-9734091", "R-CFA-114608", "R-HSA-6806942", "R-RNO-140837", "R-BTA-8957275", "R-MMU-456926", "R-CFA-8851805", "R-RNO-6811558", "R-MMU-8851805", "R-HSA-166663", "R-MMU-5673001", "R-BTA-140834", "R-RNO-6806942", "R-HSA-1474228", "R-HSA-9694786", "R-MMU-5578768", "R-CFA-159782", "R-CFA-8874081", "R-HSA-9660826", "R-HSA-2022377", "R-RNO-75108", "R-MMU-75108", "R-HSA-159740", "R-RNO-8875656", "R-RNO-8851805", "R-CFA-6806942", "R-HSA-173736", "R-HSA-9927020", "R-CFA-8875656", "R-MMU-186797", "R-RNO-6798695", "R-RNO-8851907", "R-CFA-8875791", "R-MMU-9837999", "R-CFA-202733", "R-HSA-9705671", "R-HSA-8854214", "R-HSA-375276", "R-HSA-3000480", "R-HSA-9682706", "R-MMU-8874081", "R-HSA-8851907", "R-RNO-5620971", "R-CFA-6811558", "R-MMU-159763", "R-HSA-9837999", "R-MMU-6803157", "R-GGA-1592389", "R-MMU-9734091", "R-HSA-1442490", "R-MMU-1300645", "R-CFA-1592389", "R-MMU-977606", "R-RNO-1592389", "R-MMU-189451", "R-RNO-8875791", "R-HSA-9841251", "R-HSA-9760173", "R-HSA-8964041", "R-BTA-174577", "R-MMU-140875", "R-DME-1474228", "R-RNO-6807004", "R-HSA-9864848", "R-CFA-75205", "R-MMU-6807004", "R-HSA-8875656", "R-HSA-9673218", "R-HSA-202733", "R-CFA-140875", "R-MMU-163125", "R-MMU-159740", "R-GGA-159782", "R-HSA-2168880", "R-MMU-166663", "R-MMU-375276", "R-RNO-448706", "R-HSA-1368108", "R-MMU-8957275", "R-RNO-977606", "R-RNO-202733", "R-BTA-9837999", "R-HSA-6803157", "R-HSA-9635465", "R-RNO-8852405", "R-CFA-8851907", "R-HSA-5621480", "R-HSA-75205", "R-HSA-381426", "R-HSA-9629569", "R-MMU-2022377", "R-CFA-159763", "R-HSA-456926", "R-MMU-140837", "R-HSA-2219530", "R-HSA-6785807", "R-GGA-6798695", "R-MMU-8875555", "R-HSA-9673221", "R-HSA-9911233", "R-MMU-1462054", "R-HSA-9758881", "R-RNO-8875555", "R-XTR-114608", "R-HSA-9679504", "R-HSA-449836", "R-SSC-114608", "R-HSA-9925561", "R-HSA-416476", "R-HSA-76009", "R-BTA-114608", "R-HSA-448706", "R-RNO-8957275", "R-BTA-381426", "R-HSA-9920951", "R-HSA-9918481", "R-MMU-1442490", "R-HSA-9734091", "R-CFA-381426", "R-RNO-6809371", "R-DME-9837999", "R-MMU-75205", "R-HSA-1592389", "R-HSA-1433557", "R-HSA-9694271", "R-SSC-6809371", "R-HSA-9694301"], "pathways": ["R-HSA-8874081:r:MET activates PTK2 signaling", "R-SSC-2168880:r:Scavenging of heme from plasma", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9673202:r:Defective F9 variant does not activate FX", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MMU-166662:r:Lectin pathway of complement activation", "R-GGA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-CFA-6807004:r:Negative regulation of MET activity", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-SSC-174577:r:Activation of C3 and C5", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-MMU-9864848:r:Complex IV assembly", "R-RNO-416476:r:G alpha (q) signalling events", "R-BTA-977606:r:Regulation of Complement cascade", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-CFA-8875513:r:MET interacts with TNS proteins", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-173736:r:Alternative complement activation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-GGA-6803157:r:Antimicrobial peptides", "R-MMU-448706:r:Interleukin-1 processing", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-BTA-189451:r:Heme biosynthesis", "R-HSA-8865999:r:MET activates PTPN11", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-191859:r:snRNP Assembly", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-5620971:r:Pyroptosis", "R-BTA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-CFA-159740:r:Gamma-carboxylation of protein precursors", "R-DME-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-GGA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-8852405:r:Signaling by MST1", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-SSC-75205:r:Dissolution of Fibrin Clot", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-BTA-166663:r:Initial triggering of complement", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-SSC-186797:r:Signaling by PDGF", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-8875791:r:MET activates STAT3", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-8865999:r:MET activates PTPN11", "R-CFA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9678110:r:Attachment and Entry", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9673240:r:Defective gamma-carboxylation of F9", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-CFA-186797:r:Signaling by PDGF", "R-RNO-8865999:r:MET activates PTPN11", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-RNO-6803157:r:Antimicrobial peptides", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-9918432:r:Maturation of DENV proteins", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-RNO-5578768:r:Physiological factors", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-XTR-6798695:r:Neutrophil degranulation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1462054:r:Alpha-defensins", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-SSC-173736:r:Alternative complement activation", "R-CFA-8875555:r:MET activates RAP1 and RAC1", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-189451:r:Heme biosynthesis", "R-HSA-9672383:r:Defective factor IX causes thrombophilia", "R-MMU-114608:r:Platelet degranulation", "R-XTR-173736:r:Alternative complement activation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-BTA-173736:r:Alternative complement activation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-166662:r:Lectin pathway of complement activation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-BTA-9864848:r:Complex IV assembly", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-114608:r:Platelet degranulation", "R-HSA-5578768:r:Physiological factors", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-8852405:r:Signaling by MST1", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-174577:r:Activation of C3 and C5", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-8851805:r:MET activates RAS signaling", "R-BTA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-1462054:r:Alpha-defensins", "R-CFA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-SSC-977606:r:Regulation of Complement cascade", "R-MMU-6806942:r:MET Receptor Activation", "R-CFA-8865999:r:MET activates PTPN11", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-5620971:r:Pyroptosis", "R-GGA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-CFA-9734091:r:Drug-mediated inhibition of MET activation", "R-CFA-114608:r:Platelet degranulation", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CFA-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-HSA-166663:r:Initial triggering of complement", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-RNO-6806942:r:MET Receptor Activation", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-MMU-5578768:r:Physiological factors", "R-CFA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-CFA-8874081:r:MET activates PTK2 signaling", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-MMU-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-8851805:r:MET activates RAS signaling", "R-CFA-6806942:r:MET Receptor Activation", "R-HSA-173736:r:Alternative complement activation", "R-HSA-9927020:r:Heme assimilation", "R-CFA-8875656:r:MET receptor recycling", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-8875791:r:MET activates STAT3", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CFA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-5620971:r:Pyroptosis", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-6803157:r:Antimicrobial peptides", "R-GGA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-189451:r:Heme biosynthesis", "R-RNO-8875791:r:MET activates STAT3", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-8964041:r:LDL remodeling", "R-BTA-174577:r:Activation of C3 and C5", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-9864848:r:Complex IV assembly", "R-CFA-75205:r:Dissolution of Fibrin Clot", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-8875656:r:MET receptor recycling", "R-HSA-9673218:r:Defective F9 secretion", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-CFA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-GGA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-166663:r:Initial triggering of complement", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-448706:r:Interleukin-1 processing", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-202733:r:Cell surface interactions at the vascular wall", 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"R-XTR-110320:r:Translesion Synthesis by POLH", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-8876725:r:Protein methylation", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-XTR-5358346:r:Hedgehog ligand biogenesis", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-SPO-3371511:r:HSF1 activation", "R-DRE-8876725:r:Protein methylation", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-XTR-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SCE-6811438:r:Intra-Golgi traffic", "R-SCE-3371511:r:HSF1 activation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-8951664:r:Neddylation"], "type": "Homologous_superfamily"}, "IPR009011": {"description": "Mannose-6-phosphate receptor binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Man6P_isomerase_rcpt-bd_dom_sf", "pathway_ids": ["R-HSA-6798695", "R-MMU-9840310", "R-SPO-6798695", "R-HSA-9683686", "R-HSA-879415", "R-MMU-8856828", "R-RNO-9840310", "R-HSA-901032", "R-MMU-8856825", "R-XTR-382556", "R-HSA-8856828", "R-HSA-9694548", "R-MMU-432722", "R-SCE-6798695", "R-RNO-382556", "R-HSA-6811440", "R-MMU-8957275", "R-BTA-8957275", "R-BTA-9840310", "R-SPO-8856825", "R-XTR-9931269", "R-MMU-381426", "R-BTA-381426", "R-MMU-5358346", "R-HSA-5362768", "R-RNO-8856828", "R-MMU-432720", "R-HSA-432722", "R-HSA-901042", "R-HSA-381426", "R-BTA-8856828", "R-HSA-532668", "R-MMU-382556", "R-HSA-9931269", "R-RNO-6811440", "R-RNO-8856825", "R-RNO-432720", "R-BTA-432720", "R-HSA-432720", "R-HSA-9840310", "R-HSA-382556", "R-HSA-5678895", "R-BTA-6811440", "R-RNO-9931269", "R-MMU-6811440", "R-BTA-8856825", "R-XTR-5358346", "R-HSA-8856825", "R-RNO-5358346", "R-BTA-9768727", "R-SCE-8856825", "R-MMU-9931269", "R-MMU-6798695", "R-HSA-8957275", "R-SPO-9840310", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-5358346"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-382556:r:ABC-family proteins mediated transport", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9694548:r:Maturation of spike protein", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-5358346:r:Hedgehog ligand biogenesis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SPO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Homologous_superfamily"}, "IPR009012": {"description": "GrpE nucleotide exchange factor, head", "go_ids": ["GO:0006457"], "go_terms": ["GO:0006457:protein folding:P"], "name": "GrpE_head", "pathway_ids": ["R-HSA-9918481", "R-HSA-1268020"], "pathways": ["R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-1268020:r:Mitochondrial protein import"], "type": "Homologous_superfamily"}, "IPR009013": {"description": "Attachment protein shaft domain superfamily", "go_ids": ["GO:0019062"], "go_terms": ["GO:0019062:virion attachment to host cell:P"], "name": "Attachment_protein_shaft_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR009014": {"description": "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II", "go_ids": [], "go_terms": [], "name": "Transketo_C/PFOR_II", "pathway_ids": ["PWY-6892", "PWY-6891", "PWY-7560", "R-MMU-71336", "R-HSA-71336", "R-DDI-9859138", "R-MMU-9837999", "R-SPO-9861559", "R-BTA-5362517", "R-DME-9861559", "R-MMU-163754", "R-MMU-9861559", "R-BTA-204174", "R-MMU-70895", "R-BTA-9859138", "R-BTA-9837999", "R-CEL-9861559", "R-HSA-9837999", "R-HSA-9912481", "R-HSA-5362517", "R-HSA-9818028", "R-HSA-9859138", "R-RNO-9861559", "R-RNO-163754", "R-DME-204174", "R-BTA-70895", "R-DDI-9837999", "R-HSA-204174", "R-SPO-5362517", "R-CEL-9837999", "R-RNO-204174", "R-BTA-9861559", "R-CEL-5362517", "R-CEL-204174", "R-HSA-9865125", "R-DME-9837999", "R-HSA-9907570", "R-HSA-70895", "R-RNO-9837999", "R-RNO-71336", "R-HSA-9861559", "R-RNO-70895", "R-MMU-204174", "R-RNO-9859138", "R-SCE-9861559", "R-MMU-9859138", "R-SPO-9837999", "R-SCE-9837999", "R-MMU-5362517", "R-HSA-9865113", "R-HSA-9912529", "R-DDI-9861559", "R-HSA-163754", "R-DME-5362517", "R-SPO-204174", "R-RNO-5362517"], "pathways": ["PWY-6892:t:thiazole component of thiamine diphosphate biosynthesis I", "PWY-6891:t:thiazole component of thiamine diphosphate biosynthesis II", "PWY-7560:t:methylerythritol phosphate pathway II", "R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-DDI-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-5362517:r:Signaling by Retinoic Acid", "R-DME-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-MMU-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-MMU-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-BTA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-CEL-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-RNO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-RNO-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-DME-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-BTA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-CEL-5362517:r:Signaling by Retinoic Acid", "R-CEL-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-9865125:r:Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9907570:r:Loss-of-function mutations in DLD cause MSUD3/DLDD", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-71336:r:Pentose phosphate pathway", "R-HSA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SCE-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-MMU-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-DDI-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-DME-5362517:r:Signaling by Retinoic Acid", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-5362517:r:Signaling by Retinoic Acid"], "type": "Homologous_superfamily"}, "IPR009015": {"description": "L-fucose isomerase, N-terminal/central domain superfamily", "go_ids": ["GO:0005737", "GO:0005996", "GO:0016861"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0005996:monosaccharide metabolic process:P", "GO:0016861:intramolecular oxidoreductase activity, interconverting aldoses and ketoses:F"], "name": "Fucose_isomerase_N/cen_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR009016": {"description": "Iron hydrogenase", "go_ids": [], "go_terms": [], "name": "Fe_hydrogenase", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Homologous_superfamily"}, "IPR009017": {"description": "Green fluorescent protein", "go_ids": [], "go_terms": [], "name": "GFP", "pathway_ids": ["R-HSA-1474228", "R-RNO-3000157", "R-MMU-3000157", "R-HSA-3000157", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-3000157:r:Laminin interactions", "R-MMU-3000157:r:Laminin interactions", "R-HSA-3000157:r:Laminin interactions", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Homologous_superfamily"}, "IPR009018": {"description": "Signal recognition particle, SRP9/SRP14 subunit", "go_ids": ["GO:0006614", "GO:0008312", "GO:0048500"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P", "GO:0008312:7S RNA binding:F", "GO:0048500:signal recognition particle:C"], "name": "Signal_recog_particle_SRP9/14", "pathway_ids": ["R-HSA-1799339", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-DME-1799339", "R-SPO-1799339", "R-CEL-1799339", "R-CEL-6798695", "R-SCE-1799339", "R-SCE-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-DDI-1799339", "R-BTA-1799339", "R-MMU-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Homologous_superfamily"}, "IPR009019": {"description": "K homology domain superfamily, prokaryotic type", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "KH_sf_prok-type", "pathway_ids": ["R-HSA-5419276", "R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-CFA-1799339", "R-CFA-72695", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-HSA-72695", "R-RNO-72695", "R-MMU-72706", "R-HSA-975956", "R-BTA-72689", "R-CFA-72702", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-CFA-72706", "R-HSA-5368286", "R-DDI-9954714", "R-RNO-5419276", "R-CEL-72706", "R-BTA-72695", "R-HSA-5389840", "R-RNO-9937383", "R-CEL-9954716", "R-CEL-9954714", "R-SCE-72702", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-DDI-72695", "R-CEL-1799339", "R-SSC-9954714", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-BTA-9937383", "R-HSA-72702", "R-CEL-156827", "R-CFA-156827", "R-RNO-72649", "R-RNO-6791226", "R-SSC-1799339", "R-CEL-9937383", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-SSC-72689", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-MMU-5389840", "R-SPO-72689", "R-CEL-72689", "R-CFA-9954714", "R-DDI-72689", "R-DDI-72702", "R-MMU-1799339", "R-SPO-72702", "R-HSA-9954716", "R-DDI-975956", "R-CFA-975957", "R-DME-156827", "R-MMU-9937383", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-SSC-72695", "R-BTA-5389840", "R-SSC-9954716", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-DRE-9937383", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-SSC-72702", "R-CFA-72689", "R-SCE-72689", "R-SCE-72695", "R-DRE-5419276", "R-MMU-72695", "R-MMU-975956", "R-RNO-5389840", "R-CFA-9954716", "R-SCE-156827", "R-DME-975957", "R-DME-72695", "R-MMU-72702", "R-DME-975956", "R-BTA-9954716", "R-SPO-72649", 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"R-DDI-6807878:r:COPI-mediated anterograde transport", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-8964038:r:LDL clearance", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Homologous_superfamily"}, "IPR009029": {"description": "Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily", "go_ids": ["GO:0015936", "GO:0016616"], "go_terms": ["GO:0015936:coenzyme A metabolic process:P", "GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "HMG_CoA_Rdtase_sub-bd_dom_sf", "pathway_ids": ["PWY-7524", "PWY-7391", "PWY-922", "PWY-8125", "PWY-6174", "R-SCE-9969896", "R-HSA-1989781", "R-DME-9969896", "R-RNO-9969896", "R-BTA-9969896", "R-HSA-9619665", "R-DDI-9969896", "R-MMU-9969896", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["PWY-7524:t:mevalonate pathway III (Thermoplasma)", 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"R-HSA-1227986", "R-HSA-9937080", "R-HSA-9665233", "R-RNO-186797", "R-CEL-416572", "R-RNO-1442490", "R-RNO-2428928", "R-BTA-8856825", "R-RNO-74751", "R-HSA-3928663", "R-BTA-8964038", "R-MMU-8866376", "R-MMU-3928662", "R-RNO-1236394", "R-HSA-8957275", "R-DRE-3928665", "R-RNO-182971", "R-GGA-159763", "R-DME-179812", "R-HSA-2197563", "R-DME-9013423", "R-MMU-2129379", "R-MMU-177929", "R-RNO-1306955", "R-HSA-2243919", "R-CEL-3928664", "R-DRE-186797", "R-HSA-3000178", "R-HSA-9665251", "R-RNO-2428933", "R-RNO-1474228", "R-DME-9652282", "R-HSA-9918485", "R-RNO-9009391", "R-MMU-9013408", "R-MMU-9009391", "R-DME-1912420", "R-RNO-140875", "R-RNO-8863795", "R-RNO-140837", "R-BTA-8957275", "R-HSA-5083630", "R-HSA-2979096", "R-CEL-2129379", "R-HSA-166665", "R-RNO-8847993", "R-RNO-6811558", "R-CEL-1257604", "R-MMU-9013420", "R-RNO-1963642", "R-MMU-9652282", "R-HSA-3359462", "R-HSA-2682334", "R-MMU-5620912", "R-DME-1251985", "R-MMU-1566948", "R-MMU-5673001", "R-HSA-2122947", "R-RNO-212718", 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events triggered by IGF1R", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9953170:r:GBP-mediated host defense", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DME-77387:r:Insulin receptor recycling", "R-MMU-8963889:r:Assembly of active 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"R-HSA-913709:r:O-linked glycosylation of mucins", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-74752:r:Signaling by Insulin receptor", "R-CEL-1566948:r:Elastic fibre formation", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-GGA-140875:r:Common 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Transmission of Signal to the Nucleus", "R-DRE-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-MMU-216083:r:Integrin cell surface interactions", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-CEL-1227986:r:Signaling by ERBB2", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9824272:r:Somitogenesis", "R-MMU-166665:r:Terminal pathway of complement", "R-BTA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-114608:r:Platelet degranulation", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-CFA-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-8964038:r:LDL clearance", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-177929:r:Signaling by EGFR", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-376176:r:Signaling by ROBO receptors", "R-HSA-6805567:r:Keratinization", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-MMU-74713:r:IRS activation", "R-GGA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-1227986:r:Signaling by 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repulsion of cells", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-MMU-9696273:r:RND1 GTPase cycle", "R-BTA-216083:r:Integrin cell surface interactions", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-9953170:r:GBP-mediated host defense", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-BTA-8964026:r:Chylomicron clearance", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-XTR-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-180292:r:GAB1 signalosome", "R-HSA-171286:r:Synthesis and processing of ENV and VPU", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8964046:r:VLDL clearance", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-74752:r:Signaling by Insulin receptor", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-DRE-4641263:r:Regulation of FZD by ubiquitination", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-3000157:r:Laminin interactions", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-RNO-8964038:r:LDL clearance", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic 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Signal to the Nucleus", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-166665:r:Terminal pathway of complement", "R-CEL-216083:r:Integrin cell surface interactions", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-3928664:r:Ephrin signaling", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-CEL-180292:r:GAB1 signalosome", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9694614:r:Attachment and Entry", "R-RNO-1566948:r:Elastic fibre formation", "R-CEL-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-6809371:r:Formation of the cornified envelope", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-XTR-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-114608:r:Platelet degranulation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-1566948:r:Elastic fibre formation", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-114608:r:Platelet degranulation", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-977606:r:Regulation of Complement cascade", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem 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"R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-CEL-3928664:r:Ephrin signaling", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-DME-1912420:r:Pre-NOTCH Processing in Golgi", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-HSA-166665:r:Terminal pathway of complement", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-3359462:r:Defective AMN causes MGA1", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-MMU-1566948:r:Elastic fibre formation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-77387:r:Insulin receptor recycling", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-182971:r:EGFR downregulation", "R-BTA-1566948:r:Elastic fibre formation", "R-CFA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-DME-6809371:r:Formation of the cornified envelope", "R-HSA-9609690:r:HCMV Early Events", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-376176:r:Signaling by ROBO receptors", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-9758890:r:Transport of RCbl within the body", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-445144:r:Signal transduction by L1", "R-DME-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-DME-182971:r:EGFR downregulation", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CFA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-373760:r:L1CAM interactions", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-1181150:r:Signaling by NODAL", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling"], "type": "Homologous_superfamily"}, "IPR009031": {"description": "Carbohydrate binding module family 10", "go_ids": ["GO:0030248", "GO:0005975"], "go_terms": ["GO:0030248:cellulose binding:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "CBM10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009032": {"description": "Vpu protein cytoplasmic domain superfamily", "go_ids": ["GO:0042609"], "go_terms": ["GO:0042609:CD4 receptor binding:F"], "name": "Vpu_cyt_dom_sf", "pathway_ids": ["R-HSA-180910", "R-HSA-162592", "R-HSA-171286", "R-HSA-177539", "R-HSA-180534", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-164525", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-173107", 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retrograde traffic"], "type": "Domain"}, "IPR009042": {"description": "RNA polymerase sigma-70 region 1.2", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma70_r1_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009044": {"description": "ssDNA-binding transcriptional regulator", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "ssDNA-bd_transcriptional_reg", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR009045": {"description": "Peptidase M74/Hedgehog-like, zinc-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Zn_M74/Hedgehog-like", "pathway_ids": ["R-HSA-373080", "R-DRE-5358346", "R-MMU-5635838", "R-DME-5362798", "R-GGA-5632681", "R-HSA-9937080", "R-GGA-5358346", "R-RNO-5632681", "R-HSA-5632684", "R-DRE-5362798", "R-DME-5632681", "R-DME-209338", "R-DME-209471", "R-MMU-5632681", "R-HSA-5632681", "R-HSA-5362798", "R-HSA-8941284", "R-MMU-5362798", "R-HSA-5635838", "R-DRE-5632681", "R-MMU-5358346", "R-HSA-9758920", "R-HSA-5362768", "R-HSA-9796292", "R-HSA-5658034", "R-RNO-5362798", "R-GGA-5362798", "R-RNO-5358346", "R-HSA-9690406", "R-DME-5358346", "R-HSA-5358346"], "pathways": ["R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5635838:r:Activation of SMO", "R-DME-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5632681:r:Ligand-receptor interactions", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-DME-5632681:r:Ligand-receptor interactions", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-5632681:r:Ligand-receptor interactions", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-5635838:r:Activation of SMO", "R-DRE-5632681:r:Ligand-receptor interactions", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-5658034:r:HHAT G278V doesn't palmitoylate Hh-Np", "R-RNO-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Homologous_superfamily"}, "IPR009047": {"description": "Methyl-coenzyme M reductase, alpha subunit, C-terminal", "go_ids": ["GO:0015948", "GO:0050524"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_asu_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009048": {"description": "Alpha-macroglobulin, receptor-binding", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "A-macroglobulin_rcpt-bd", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-MMU-163125", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-163125", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR009049": {"description": "Argininosuccinate lyase", "go_ids": ["GO:0004056", "GO:0006526"], "go_terms": ["GO:0004056:argininosuccinate lyase activity:F", "GO:0006526:L-arginine biosynthetic process:P"], "name": "Argininosuccinate_lyase", "pathway_ids": ["PWY-7400", "PWY-4984", "PWY-5", "PWY-4983", "PWY-5154", "R-BTA-70635", "R-MMU-70635", "R-HSA-70635", "R-SPO-70635", "R-GGA-187630", "R-SCE-70635", "R-RNO-70635", "R-HSA-9956529"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-4984:t:urea cycle", "PWY-5:t:canavanine biosynthesis", "PWY-4983:t:nitric oxide biosynthesis II (mammals)", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-BTA-70635:r:Urea cycle", "R-MMU-70635:r:Urea cycle", "R-HSA-70635:r:Urea cycle", "R-SPO-70635:r:Urea cycle", "R-GGA-187630:r:Arginine metabolism", "R-SCE-70635:r:Urea cycle", "R-RNO-70635:r:Urea cycle", "R-HSA-9956529:r:ASL variants cause argininosuccinate aciduria"], "type": "Family"}, "IPR009050": {"description": "Globin-like superfamily", "go_ids": [], "go_terms": [], "name": "Globin-like_sf", "pathway_ids": ["R-HSA-6798695", "R-GGA-9707564", "R-RNO-1237044", "R-MMU-9707564", "R-RNO-1247673", "R-HSA-1247673", "R-BTA-2168880", "R-HSA-2168880", "R-GGA-1247673", "R-BTA-6798695", "R-XTR-2168880", "R-MMU-203615", "R-HSA-1237044", "R-BTA-1247673", "R-GGA-1237044", "R-HSA-203615", "R-HSA-8981607", "R-XTR-1237044", "R-MMU-9707616", "R-DRE-6798695", "R-HSA-9707564", "R-RNO-9707616", "R-HSA-9615710", "R-GGA-9707616", "R-MMU-2168880", "R-MMU-1237044", "R-DRE-8981607", "R-HSA-1222538", "R-MMU-1247673", "R-RNO-2168880", "R-HSA-983231", "R-GGA-2168880", "R-DRE-203615", "R-RNO-9707564", "R-HSA-9707616", "R-BTA-9707616", "R-XTR-6798695", "R-GGA-6798695", "R-XTR-9707616", "R-RNO-203615", "R-MMU-8981607", "R-RNO-8981607", "R-BTA-8981607", "R-XTR-9707564", "R-XTR-1247673", "R-HSA-9927020", "R-SSC-8981607", "R-HSA-9613829", "R-BTA-1237044", "R-RNO-6798695", "R-GGA-8981607", "R-BTA-9707564"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-2168880:r:Scavenging of heme from plasma", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-GGA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-6798695:r:Neutrophil degranulation", "R-XTR-2168880:r:Scavenging of heme from plasma", "R-MMU-203615:r:eNOS activation", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-BTA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-GGA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-203615:r:eNOS activation", "R-HSA-8981607:r:Intracellular oxygen transport", "R-XTR-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-9707616:r:Heme signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-RNO-9707616:r:Heme signaling", "R-HSA-9615710:r:Late endosomal microautophagy", "R-GGA-9707616:r:Heme signaling", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DRE-8981607:r:Intracellular oxygen transport", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-2168880:r:Scavenging of heme from plasma", "R-DRE-203615:r:eNOS activation", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707616:r:Heme signaling", "R-BTA-9707616:r:Heme signaling", "R-XTR-6798695:r:Neutrophil degranulation", "R-GGA-6798695:r:Neutrophil degranulation", "R-XTR-9707616:r:Heme signaling", "R-RNO-203615:r:eNOS activation", "R-MMU-8981607:r:Intracellular oxygen transport", "R-RNO-8981607:r:Intracellular oxygen transport", "R-BTA-8981607:r:Intracellular oxygen transport", "R-XTR-9707564:r:Cytoprotection by HMOX1", "R-XTR-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-9927020:r:Heme assimilation", "R-SSC-8981607:r:Intracellular oxygen transport", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-6798695:r:Neutrophil degranulation", "R-GGA-8981607:r:Intracellular oxygen transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR009051": {"description": "Alpha-helical ferredoxin", "go_ids": ["GO:0051536"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F"], "name": "Helical_ferredxn", "pathway_ids": ["R-XTR-71403", "R-HSA-9854311", "R-DDI-73621", "R-RNO-73621", "R-DRE-9854311", "R-GGA-372987", "R-HSA-73621", "R-DRE-71403", "R-RNO-9854311", "R-HSA-611105", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-MMU-71403", "R-SCE-71403", "R-XTR-9854311", "R-DME-71403", "R-DDI-71403", "R-RNO-71403", "R-DRE-73621", "R-MMU-73621", "R-CEL-73621", "R-HSA-71403"], "pathways": ["R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-73621:r:Pyrimidine catabolism", "R-RNO-73621:r:Pyrimidine catabolism", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-HSA-73621:r:Pyrimidine catabolism", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-611105:r:Respiratory electron transport", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-73621:r:Pyrimidine catabolism", "R-MMU-73621:r:Pyrimidine catabolism", "R-CEL-73621:r:Pyrimidine catabolism", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Homologous_superfamily"}, "IPR009052": {"description": "DNA polymerase III-theta, bacterial", "go_ids": ["GO:0003677", "GO:0003887", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P"], "name": "DNA_pol_III_theta_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009053": {"description": "Prefoldin", "go_ids": [], "go_terms": [], "name": "Prefoldin", "pathway_ids": ["R-HSA-8953750", "R-HSA-389957"], "pathways": ["R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-389957:r:Prefoldin mediated transfer of substrate to CCT/TriC"], "type": "Homologous_superfamily"}, "IPR009056": {"description": "Cytochrome c-like domain", "go_ids": ["GO:0009055", "GO:0020037"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0020037:heme binding:F"], "name": "Cyt_c-like_dom", "pathway_ids": ["R-HSA-2151201", "R-MMU-9707564", "R-SPO-5620971", "R-DRE-611105", "R-GGA-111459", "R-DRE-111458", "R-GGA-2151201", "R-RNO-3299685", "R-BTA-9627069", "R-MMU-111459", "R-DDI-3299685", "R-RNO-111458", "R-CFA-611105", "R-BTA-5620971", "R-SCE-5620971", 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chromatin organization proteins", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-110331:r:Cleavage of the damaged purine", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SPO-3214842:r:HDMs demethylate histones", "R-DDI-68952:r:DNA replication initiation", "R-BTA-73728:r:RNA Polymerase I Promoter Opening", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-210993:r:Tie2 Signaling", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-BTA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-210993:r:Tie2 Signaling", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-3214847:r:HATs acetylate histones", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-HSA-1502540:r:Signaling by Activin", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-DME-8853659:r:RET signaling", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-427413:r:NoRC negatively regulates rRNA expression", "R-CEL-186763:r:Downstream signal transduction", "R-GGA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-9842663:r:Signaling by LTK", "R-RNO-5689603:r:UCH proteinases", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-1250347:r:SHC1 events 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"R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-8851805:r:MET activates RAS signaling", "R-DME-193648:r:NRAGE signals death through JNK", "R-DME-3214842:r:HDMs demethylate histones", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-GGA-73728:r:RNA Polymerase I Promoter Opening", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DRE-427413:r:NoRC negatively regulates rRNA expression", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-9018519:r:Estrogen-dependent gene expression", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-110331:r:Cleavage of the damaged purine", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DDI-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-427359:r:SIRT1 negatively regulates rRNA expression", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-GGA-3214842:r:HDMs demethylate histones", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-428540:r:Activation of RAC1", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5689901:r:Metalloprotease DUBs"], "type": "Homologous_superfamily"}, "IPR009073": {"description": "Co-chaperone HscB, C-terminal oligomerisation domain", "go_ids": ["GO:0051259"], "go_terms": ["GO:0051259:protein complex oligomerization:P"], "name": "HscB_oligo_C", "pathway_ids": ["R-SPO-9865881", "R-HSA-1362409", "R-HSA-9865881", "R-SCE-1362409", "R-HSA-1268020", "R-MMU-6799198", "R-HSA-6799198", "R-MMU-1362409", "R-MMU-1268020", "R-SCE-1268020", "R-SCE-9865881", "R-SPO-1268020", "R-SPO-1362409", "R-MMU-9865881"], "pathways": ["R-SPO-9865881:r:Complex III assembly", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9865881:r:Complex 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octanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-RNO-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-71064:r:Lysine catabolism", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-BTA-71064:r:Lysine catabolism", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-71064:r:Lysine catabolism", "R-MMU-6799198:r:Complex I biogenesis", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-BTA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-MMU-77289:r:Mitochondrial Fatty Acid 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"R-HSA-1632852:r:Macroautophagy", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-DME-1632852:r:Macroautophagy", "R-DME-165159:r:MTOR signalling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-165159:r:MTOR signalling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-1632852:r:Macroautophagy", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-166208:r:mTORC1-mediated signalling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-DDI-1632852:r:Macroautophagy", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DDI-166208:r:mTORC1-mediated signalling", 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vascular permeability", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Domain"}, "IPR009077": {"description": "Proteasome activator PA28", "go_ids": ["GO:0008537"], "go_terms": ["GO:0008537:proteasome activator complex:C"], "name": "Proteasome_activ_PA28", "pathway_ids": ["R-MMU-9907900", "R-BTA-9912633", "R-BTA-1236978", "R-RNO-9907900", "R-DDI-9907900", "R-DDI-9912633", "R-HSA-1236978", "R-HSA-8950505", "R-RNO-1236974", "R-RNO-9912633", "R-DDI-1236974", "R-DDI-1236978", "R-HSA-9907900", "R-SSC-9907900", "R-MMU-1236974", "R-HSA-9912633", "R-HSA-1236974", "R-MMU-1236978", "R-BTA-1236974", "R-MMU-9912633", "R-RNO-1236978", "R-BTA-9907900"], "pathways": ["R-MMU-9907900:r:Proteasome assembly", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens 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Ub, ATP-independent proteasomal degradation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-9907900:r:Proteasome assembly"], "type": "Family"}, "IPR009078": {"description": "Ferritin-like superfamily", "go_ids": [], "go_terms": [], "name": "Ferritin-like_SF", "pathway_ids": ["R-HSA-6798695", "R-HSA-69205", "R-HSA-3000480", "R-GGA-917937", "R-MMU-432722", "R-BTA-6798695", "R-CFA-432722", "R-HSA-8953750", "R-MMU-2142789", "R-HSA-499943", "R-HSA-1222449", "R-CFA-917937", "R-MMU-499943", "R-HSA-5628897", "R-SCE-2142789", "R-MMU-917937", "R-DME-499943", "R-GGA-432722", "R-HSA-2142789", "R-HSA-432722", "R-CEL-2142789", "R-RNO-432722", "R-SPO-2142789", "R-RNO-917937", "R-RNO-2142789", "R-GGA-6798695", "R-DRE-499943", "R-BTA-917937", "R-HSA-917937", "R-DDI-2142789", "R-CEL-499943", "R-MMU-6798695", "R-CFA-6798695", "R-RNO-6798695", "R-RNO-499943"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-GGA-917937:r:Iron uptake and transport", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-CFA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-CFA-917937:r:Iron uptake and transport", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-MMU-917937:r:Iron uptake and transport", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-GGA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-2142789:r:Ubiquinol biosynthesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-RNO-917937:r:Iron uptake and transport", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-GGA-6798695:r:Neutrophil degranulation", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-917937:r:Iron uptake and transport", "R-HSA-917937:r:Iron uptake and transport", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Homologous_superfamily"}, "IPR009079": {"description": "Four-helical cytokine-like, core", "go_ids": [], "go_terms": [], "name": "4_helix_cytokine-like_core", "pathway_ids": ["R-GGA-9732724", "R-HSA-9607240", "R-RNO-6785807", "R-HSA-9942503", "R-HSA-2559580", "R-MMU-9674555", "R-RNO-9020558", "R-HSA-9006335", 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"R-HSA-449836", "R-HSA-977225", "R-MMU-112411", "R-RNO-1059683", "R-SSC-6783783", "R-HSA-2559582", "R-HSA-918233", "R-HSA-76009", "R-SSC-877312", "R-HSA-8877330", "R-CFA-512988", "R-RNO-8957275", "R-RNO-381771", "R-CFA-1433559", "R-BTA-381426", "R-RNO-110056", "R-BTA-1059683", "R-GGA-6811558", "R-HSA-912694", "R-MMU-6788467", "R-GGA-381426", "R-MMU-110056", "R-HSA-381771", "R-HSA-9660821", "R-GGA-1257604", "R-MMU-8854691", "R-RNO-112411", "R-BTA-1433557", "R-HSA-9020591", "R-MMU-1170546", "R-HSA-9645135", "R-SSC-9027276", "R-MMU-8984722", "R-RNO-982772", "R-CFA-982772", "R-HSA-1433557", "R-GGA-9705462", "R-MMU-877300", "R-GGA-1433559", "R-HSA-9706377", "R-BTA-1433559", "R-SSC-5673001", "R-MMU-1059683", "R-MMU-6783783", "R-CFA-912526", "R-RNO-909733", "R-HSA-9705462", "R-HSA-8957275", "R-GGA-982772", "R-HSA-8939246", "R-BTA-6785807", "R-MMU-912694", "R-RNO-449836", "R-SSC-6788467"], "pathways": ["R-GGA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-9020558:r:Interleukin-2 signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-GGA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9020958:r:Interleukin-21 signaling", "R-CFA-9732724:r:IFNG signaling activates MAPKs", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-RNO-9020591:r:Interleukin-12 signaling", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-1433559:r:Regulation of KIT 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"R-BTA-8984722:r:Interleukin-35 Signalling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-2586552:r:Signaling by Leptin", "R-BTA-9020591:r:Interleukin-12 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-CFA-1170546:r:Prolactin receptor signaling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-HSA-1170546:r:Prolactin receptor signaling", "R-GGA-1059683:r:Interleukin-6 signaling", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-877312:r:Regulation of IFNG signaling", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-8983432:r:Interleukin-15 signaling", "R-RNO-9020958:r:Interleukin-21 signaling", "R-CFA-877300:r:Interferon gamma signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-BTA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-GGA-912694:r:Regulation of IFNA/IFNB signaling", "R-CFA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-CFA-909733:r:Interferon alpha/beta signaling", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-BTA-982772:r:Growth hormone receptor signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-9020591:r:Interleukin-12 signaling", "R-GGA-877300:r:Interferon gamma signaling", "R-RNO-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-449836:r:Other interleukin signaling", "R-BTA-449836:r:Other interleukin signaling", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-RNO-1170546:r:Prolactin receptor signaling", "R-HSA-9706369:r:Negative regulation of FLT3", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-BTA-110056:r:MAPK3 (ERK1) activation", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-MMU-109704:r:PI3K Cascade", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-109704:r:PI3K Cascade", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9706369:r:Negative regulation of FLT3", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-SSC-9020558:r:Interleukin-2 signaling", 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regulation of MITF-M expression and activity", "R-RNO-877300:r:Interferon gamma signaling", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-1433559:r:Regulation of KIT signaling", "R-BTA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-9607240:r:FLT3 Signaling", "R-BTA-1170546:r:Prolactin receptor signaling", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-SSC-449836:r:Other interleukin signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-SSC-877300:r:Interferon gamma signaling", "R-BTA-877300:r:Interferon gamma signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-877312:r:Regulation of IFNG signaling", "R-CFA-9020558:r:Interleukin-2 signaling", "R-HSA-9610379:r:HCMV Late Events", "R-GGA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-982772:r:Growth hormone receptor signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9020933:r:Interleukin-23 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-CFA-877312:r:Regulation of IFNG signaling", "R-CFA-9020958:r:Interleukin-21 signaling", "R-HSA-9012546:r:Interleukin-18 signaling", "R-GGA-6783783:r:Interleukin-10 signaling", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-SSC-6783783:r:Interleukin-10 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-SSC-877312:r:Regulation of IFNG signaling", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-CFA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-CFA-1433559:r:Regulation of KIT signaling", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-BTA-1059683:r:Interleukin-6 signaling", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-9645135:r:STAT5 Activation", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-CFA-982772:r:Growth hormone receptor signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-877300:r:Interferon gamma signaling", "R-GGA-1433559:r:Regulation of KIT signaling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-BTA-1433559:r:Regulation of KIT signaling", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-CFA-912526:r:Interleukin receptor SHC signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-GGA-982772:r:Growth hormone receptor signaling", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-BTA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-449836:r:Other interleukin signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Homologous_superfamily"}, "IPR009080": {"description": "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding", "go_ids": ["GO:0000166", "GO:0004812", "GO:0005524", "GO:0006418"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004812:aminoacyl-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0006418:tRNA aminoacylation for protein translation:P"], "name": "tRNAsynth_Ia_anticodon-bd", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9837999", "R-DDI-9856649", "R-MMU-9837999", "R-RNO-9856649", "R-DME-9856649", "R-HSA-379716", "R-BTA-9856649", "R-HSA-2408522", "R-SPO-9837999", "R-SCE-9837999", "R-GGA-9837999", "R-HSA-9856649", "R-HSA-9837999", "R-HSA-9725370"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-GGA-9837999:r:Mitochondrial protein degradation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Homologous_superfamily"}, "IPR009081": {"description": "Phosphopantetheine binding ACP domain", "go_ids": [], "go_terms": [], "name": "PP-bd_ACP", "pathway_ids": ["R-HSA-9029558", "R-MMU-9937383", "R-DDI-75105", "R-HSA-6799198", "R-DME-6799198", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-DDI-9857492", "R-MMU-199220", "R-RNO-199220", "R-DME-9857492", "R-MMU-196757", "R-MMU-611105", "R-DDI-199220", "R-XTR-196757", "R-HSA-9918481", "R-HSA-77289", "R-HSA-163765", "R-MMU-9857492", "R-MMU-6799198", "R-DME-77289", "R-HSA-9937383", "R-SCE-9857492", "R-HSA-196757", "R-MMU-75105", "R-DDI-77289", "R-HSA-9857492", "R-SCE-77289", "R-DME-611105", "R-SPO-9857492", "R-HSA-611105", "R-HSA-75105", "R-MMU-77289", "R-RNO-196757", "R-SPO-77289", "R-HSA-2426168"], "pathways": ["R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DDI-9857492:r:Protein lipoylation", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DME-9857492:r:Protein lipoylation", "R-MMU-196757:r:Metabolism of folate and pterines", "R-MMU-611105:r:Respiratory electron transport", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-XTR-196757:r:Metabolism of folate and pterines", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-MMU-9857492:r:Protein lipoylation", "R-MMU-6799198:r:Complex I biogenesis", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-9857492:r:Protein lipoylation", "R-HSA-196757:r:Metabolism of folate and pterines", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9857492:r:Protein lipoylation", "R-SCE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-611105:r:Respiratory electron transport", "R-SPO-9857492:r:Protein lipoylation", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-196757:r:Metabolism of folate and pterines", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR009083": {"description": "Transcription factor IIA, alpha-helical domain", "go_ids": ["GO:0005672", "GO:0006367"], "go_terms": ["GO:0005672:transcription factor TFIIA complex:C", "GO:0006367:transcription initiation at RNA polymerase II promoter:P"], "name": "TFIIA_a-hlx", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-RNO-6807505", "R-HSA-6807505", "R-RNO-674695", "R-SCE-75953", "R-MMU-75953", "R-DME-76042", "R-RNO-73779", "R-SPO-6807505", "R-DDI-73776", "R-DME-73779", "R-RNO-9018519", "R-RNO-73776", "R-HSA-167162", "R-SCE-6807505", "R-SPO-76042", "R-DME-73776", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-DDI-9018519", "R-CEL-75953", "R-MMU-73776", "R-DDI-76042", 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"R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167161:r:HIV Transcription Initiation", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-75953:r:RNA Polymerase II 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"R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-HSA-167161", "R-SCE-9018519", "R-DME-6807505", "R-MMU-9018519", "R-CEL-674695", "R-SCE-674695", "R-CEL-9018519", "R-SPO-73779", "R-HSA-674695", "R-HSA-76042", "R-DDI-75953", "R-SPO-73776", "R-CEL-76042", "R-RNO-75953", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167161:r:HIV Transcription Initiation", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Homologous_superfamily"}, "IPR009089": {"description": "XRCC4, N-terminal domain superfamily", "go_ids": ["GO:0003677", "GO:0005634", "GO:0006302", "GO:0006310"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006302:double-strand break repair:P", "GO:0006310:DNA recombination:P"], "name": "XRCC4_N_sf", "pathway_ids": ["R-HSA-5693571", "R-MMU-3108214", "R-DDI-5693571", "R-HSA-3108214", "R-MMU-5693571", "R-DDI-3108214", "R-HSA-164843"], "pathways": ["R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-164843:r:2-LTR circle formation"], "type": "Homologous_superfamily"}, "IPR009091": {"description": "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II", "go_ids": [], "go_terms": [], "name": "RCC1/BLIP-II", "pathway_ids": ["R-SCE-9615933", "R-DDI-354192", "R-HSA-9833482", "R-MMU-2467813", "R-RNO-9013149", "R-HSA-5693565", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-MMU-9615933", "R-MMU-69473", "R-HSA-6793080", "R-CEL-9909505", "R-HSA-5693607", "R-HSA-2980767", "R-DDI-9013423", "R-DRE-5663220", "R-HSA-9629569", "R-DDI-193648", "R-DME-9013149", "R-MMU-141444", "R-HSA-69473", "R-DDI-5673001", "R-CEL-9833482", "R-HSA-141444", "R-HSA-8876198", "R-HSA-9648025", "R-DME-9615933", "R-HSA-3301854", "R-HSA-9013149", "R-HSA-9615933", "R-MMU-8876198", "R-MMU-3108214", "R-RNO-983168", "R-MMU-5693571", "R-MMU-5663220", "R-DME-983168", "R-HSA-2467813", "R-HSA-3108214", "R-HSA-168928", "R-MMU-2980767", "R-RNO-8876198", "R-SPO-9615933", "R-HSA-936440", "R-HSA-1169408", "R-CEL-983168", "R-DDI-9013149", "R-HSA-9909505", "R-MMU-5693565", "R-DDI-381676", "R-CEL-936440", "R-HSA-68877", "R-HSA-165054", "R-HSA-9833110", "R-SCE-983168", "R-MMU-9648025", "R-DDI-1169408", "R-MMU-5693607", "R-DDI-9833482", "R-MMU-2500257", "R-HSA-9937008", "R-DDI-171007", "R-HSA-2500257", "R-DDI-936440", "R-DME-8876198", "R-DRE-2500257", "R-DDI-392517", "R-HSA-983168", "R-CEL-9615933", "R-DDI-983168", "R-HSA-5693571", "R-MMU-9629569", "R-CEL-1169408", "R-DDI-9909505", "R-MMU-983168", "R-HSA-5663220", "R-HSA-180746", "R-MMU-9013149", "R-DDI-1169092"], "pathways": ["R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DDI-354192:r:Integrin signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-CEL-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-9629569:r:Protein hydroxylation", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-9833110:r:RSV-host interactions", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-DDI-171007:r:p38MAPK events", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-392517:r:Rap1 signalling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-9629569:r:Protein hydroxylation", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DDI-1169092:r:Activation of RAS in B cells"], "type": "Homologous_superfamily"}, "IPR009092": {"description": "Telokin-like protein, Tlp20, baculovirus", "go_ids": [], "go_terms": [], "name": "Telokin-like_Tlp20_baculovir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009093": {"description": "Bacteriophage P22 tailspike, N-terminal", "go_ids": [], "go_terms": [], "name": "P22_tailspike_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009094": {"description": "Disulphide bond isomerase DsbC/G, N-terminal domain superfamily", "go_ids": ["GO:0042597"], "go_terms": ["GO:0042597:periplasmic space:C"], "name": "DiS-bond_isomerase_DsbC/G_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR009095": {"description": "TRADD, N-terminal", "go_ids": ["GO:0043123", "GO:0005515"], "go_terms": ["GO:0043123:positive regulation of canonical NF-kappaB signal transduction:P", "GO:0005515:protein binding:F"], "name": "TRADD_N", "pathway_ids": ["R-BTA-69416", "R-DRE-5675482", "R-MMU-5357786", "R-HSA-5218900", "R-BTA-5357905", "R-BTA-5218900", "R-DRE-75893", "R-DRE-5357956", "R-BTA-5357956", "R-BTA-5357786", "R-HSA-5675482", "R-MMU-5675482", "R-DRE-3371378", "R-HSA-75893", "R-MMU-5357956", "R-HSA-5357786", "R-HSA-69416", "R-DRE-5218900", "R-HSA-5213460", "R-MMU-69416", "R-DRE-5357905", "R-HSA-5357905", "R-BTA-75893", "R-HSA-5357956", "R-BTA-5675482", "R-HSA-9693928", "R-MMU-5357905", "R-MMU-3371378", "R-BTA-3371378", "R-MMU-5218900", "R-HSA-140534", "R-DRE-5357786", "R-HSA-3371378", "R-DRE-69416", "R-MMU-75893"], "pathways": ["R-BTA-69416:r:Dimerization of procaspase-8", "R-DRE-5675482:r:Regulation of necroptotic cell death", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-5218900:r:CASP8 activity is inhibited", "R-DRE-75893:r:TNF signaling", "R-DRE-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-3371378:r:Regulation by c-FLIP", "R-HSA-75893:r:TNF signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-69416:r:Dimerization of procaspase-8", "R-DRE-5218900:r:CASP8 activity is inhibited", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-69416:r:Dimerization of procaspase-8", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-75893:r:TNF signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-3371378:r:Regulation by c-FLIP", "R-BTA-3371378:r:Regulation by c-FLIP", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DRE-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-3371378:r:Regulation by c-FLIP", "R-DRE-69416:r:Dimerization of procaspase-8", "R-MMU-75893:r:TNF signaling"], "type": "Domain"}, "IPR009097": {"description": "Cyclic phosphodiesterase", "go_ids": [], "go_terms": [], "name": "Cyclic_Pdiesterase", "pathway_ids": ["R-HSA-112126"], "pathways": ["R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage"], "type": "Homologous_superfamily"}, "IPR009099": {"description": "Beta-lactamase-inhibitor protein BLIP", "go_ids": [], "go_terms": [], "name": "Beta-lactamas_inhib", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009100": {"description": "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily", "go_ids": ["GO:0016627"], "go_terms": ["GO:0016627:oxidoreductase activity, acting on the CH-CH group of donors:F"], "name": "AcylCoA_DH/oxidase_NM_dom_sf", "pathway_ids": ["R-HSA-1989781", "R-DDI-390247", "R-CEL-71064", "R-HSA-6799198", "R-RNO-6799198", "R-RNO-2046106", "R-DME-77288", "R-DDI-71064", "R-HSA-77346", "R-MMU-77352", "R-RNO-77305", "R-BTA-9033241", "R-CEL-2046106", "R-RNO-9033241", "R-MMU-77346", "R-MMU-389887", "R-DME-77348", "R-RNO-77285", "R-RNO-389887", "R-DDI-193368", "R-RNO-77289", "R-BTA-9837999", "R-HSA-71064", "R-HSA-77352", "R-DDI-9033241", "R-HSA-77289", "R-DME-77346", "R-BTA-70895", "R-MMU-6799198", "R-MMU-77350", "R-DME-389887", "R-HSA-389887", "R-HSA-70895", "R-HSA-77348", "R-BTA-2046106", "R-MMU-77348", "R-BTA-77305", "R-HSA-77310", "R-BTA-77346", "R-SSC-77285", "R-HSA-390247", "R-MMU-77289", "R-RNO-193368", "R-MMU-390247", "R-HSA-2046106", "R-MMU-77288", "R-RNO-77352", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-DDI-70895", "R-RNO-77310", "R-HSA-193368", "R-HSA-77350", "R-DME-2046106", "R-HSA-77285", "R-BTA-77288", "R-CEL-193368", "R-SSC-77310", "R-RNO-77350", "R-RNO-77288", "R-DDI-389887", "R-MMU-70895", "R-MMU-77310", "R-RNO-77348", "R-HSA-9837999", "R-HSA-77305", "R-CEL-389887", "R-DME-390247", "R-BTA-71064", "R-DDI-9837999", "R-HSA-381038", "R-MMU-71064", "R-MMU-2046106", "R-MMU-193368", "R-DDI-2046106", "R-DME-9033241", "R-MMU-9033241", "R-RNO-9837999", "R-CEL-390247", "R-MMU-77285", "R-BTA-77348", "R-RNO-70895", "R-SCE-389887", "R-MMU-77305", "R-DME-193368", "R-BTA-390247", "R-HSA-9033500", "R-HSA-9033241", "R-HSA-9914355", "R-RNO-390247"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-71064:r:Lysine catabolism", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-71064:r:Lysine catabolism", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-BTA-9033241:r:Peroxisomal protein import", "R-CEL-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-77289:r:Mitochondrial Fatty Acid 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["GO:0004768", "GO:0016020", "GO:0006636"], "go_terms": ["GO:0004768:stearoyl-CoA 9-desaturase activity:F", "GO:0016020:membrane:C", "GO:0006636:unsaturated fatty acid biosynthetic process:P"], "name": "Acyl-CoA_deSatase_haem/ster-bd", "pathway_ids": ["PWY-5996", "PWY-5987", "R-SPO-75105", "R-SCE-75105"], "pathways": ["PWY-5996:t:oleate biosynthesis II (animals and fungi)", "PWY-5987:t:sorgoleone biosynthesis", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Family"}, "IPR009161": {"description": "ATP-dependent 6-phosphofructokinase, eukaryotic-type", "go_ids": ["GO:0003872", "GO:0005737", "GO:0006096", "GO:0005524"], "go_terms": ["GO:0003872:6-phosphofructokinase activity:F", "GO:0005737:cytoplasm:C", "GO:0006096:glycolytic process:P", "GO:0005524:ATP binding:F"], "name": "6-Pfructokinase_euk", "pathway_ids": ["PWY-5484", "PWY-1861", "PWY-1042", "PWY-7385", "R-RNO-6798695", "R-HSA-6798695", "R-SPO-6798695", "R-MMU-70171", "R-SCE-70171", "R-DME-6798695", "R-BTA-70171", "R-CEL-6798695", "R-SCE-6798695", "R-DME-70171", "R-BTA-6798695", "R-CEL-70171", "R-RNO-70171", "R-MMU-6798695", "R-HSA-70171", "R-SPO-70171"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1042:t:glycolysis IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-70171:r:Glycolysis", "R-SCE-70171:r:Glycolysis", "R-DME-6798695:r:Neutrophil degranulation", "R-BTA-70171:r:Glycolysis", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-70171:r:Glycolysis", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-70171:r:Glycolysis", "R-RNO-70171:r:Glycolysis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis"], "type": "Family"}, "IPR009162": {"description": "RNA polymerase, 30kDa subunit, chordopox-type", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "RNA_pol_30_chordopoxvir-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009163": {"description": "Ap4A phosphorylase 1/2", "go_ids": ["GO:0003877", "GO:0005524", "GO:0009117"], "go_terms": ["GO:0003877:ATP:ADP adenylyltransferase activity:F", "GO:0005524:ATP binding:F", "GO:0009117:nucleotide metabolic process:P"], "name": "Ap4A_phos1/2", "pathway_ids": ["PWY-5279"], "pathways": ["PWY-5279:t:sulfite oxidation II"], "type": "Family"}, "IPR009164": {"description": "Fructose-1,6-bisphosphatase class 3", "go_ids": ["GO:0006094", "GO:0042132"], "go_terms": ["GO:0006094:gluconeogenesis:P", "GO:0042132:fructose 1,6-bisphosphate 1-phosphatase activity:F"], "name": "FBPtase_class3", "pathway_ids": ["PWY-5484"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)"], "type": "Family"}, "IPR009165": {"description": "S-adenosylmethionine decarboxylase, bacterial", "go_ids": ["GO:0004014", "GO:0008295"], "go_terms": ["GO:0004014:adenosylmethionine decarboxylase activity:F", "GO:0008295:spermidine biosynthetic process:P"], "name": "S-AdoMet_deCO2ase_bac", "pathway_ids": ["PWY-6834"], "pathways": ["PWY-6834:t:spermidine biosynthesis III"], "type": "Family"}, "IPR009167": {"description": "Erythropoietin receptor", "go_ids": ["GO:0004888", "GO:0016020"], "go_terms": ["GO:0004888:transmembrane signaling receptor activity:F", "GO:0016020:membrane:C"], "name": "Erythropoietin_rcpt", "pathway_ids": ["R-RNO-9006335", "R-SSC-9027276", "R-HSA-9006335", "R-MMU-9027276", "R-HSA-9027277", "R-SSC-9006335", "R-HSA-9027284", "R-SSC-9027284", "R-MMU-9006335", "R-RNO-9027276", "R-HSA-9027283", "R-MMU-9027284", "R-RNO-9027284", "R-HSA-9027276"], "pathways": ["R-RNO-9006335:r:Signaling by Erythropoietin", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "type": "Family"}, "IPR009169": {"description": "Calreticulin", "go_ids": ["GO:0005509", "GO:0005783", "GO:0006457"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0005783:endoplasmic reticulum:C", "GO:0006457:protein folding:P"], "name": "Calreticulin", "pathway_ids": ["R-HSA-3000484", "R-RNO-983170", "R-HSA-381183", "R-SSC-901042", "R-HSA-3000480", "R-HSA-9918432", "R-CEL-901042", "R-DDI-901042", "R-MMU-901042", "R-MMU-3000480", "R-DME-901042", "R-RNO-901042", "R-HSA-983170", "R-HSA-901042", "R-SSC-3000480", "R-SSC-983170", "R-MMU-983170", "R-HSA-168316", "R-HSA-1236974", "R-RNO-3000480"], "pathways": ["R-HSA-3000484:r:Scavenging by Class F Receptors", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-381183:r:ATF6 (ATF6-alpha) activates chaperone genes", "R-SSC-901042:r:Calnexin/calreticulin cycle", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CEL-901042:r:Calnexin/calreticulin cycle", "R-DDI-901042:r:Calnexin/calreticulin cycle", "R-MMU-901042:r:Calnexin/calreticulin cycle", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-DME-901042:r:Calnexin/calreticulin cycle", "R-RNO-901042:r:Calnexin/calreticulin cycle", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-SSC-3000480:r:Scavenging by Class A Receptors", "R-SSC-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-1236974:r:ER-Phagosome pathway", "R-RNO-3000480:r:Scavenging by Class A Receptors"], "type": "Family"}, "IPR009170": {"description": "PR domain zinc finger protein 2", "go_ids": ["GO:0042054"], "go_terms": ["GO:0042054:histone methyltransferase activity:F"], "name": "PRDM2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009172": {"description": "Orthopoxvirus C13", "go_ids": [], "go_terms": [], "name": "Orthopox_C13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009173": {"description": "Chemokine-binding protein, viral", "go_ids": [], "go_terms": [], "name": "Chemkine-bd_vir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009174": {"description": "Orthopoxvirus, Protein K7", "go_ids": ["GO:0052031"], "go_terms": ["GO:0052031:symbiont-mediated perturbation of host defense response:P"], "name": "Orthopox_K7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009175": {"description": "Poxvirus I2", "go_ids": [], "go_terms": [], "name": "Poxvirus_I2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009176": {"description": "Vaccinia virus, B7/C8", "go_ids": [], "go_terms": [], "name": "Vaccinia_virus_B7/C8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009177": {"description": "Orthopoxvirus C5", "go_ids": [], "go_terms": [], "name": "Orthopox_C5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009179": {"description": "Protein E3", "go_ids": ["GO:0003723", "GO:0052027"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0052027:symbiont-mediated perturbation of host signal transduction pathway:P"], "name": "E3L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009181": {"description": "Methanogenesis marker 8 protein", "go_ids": [], "go_terms": [], "name": "Methan_mark_8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009183": {"description": "MTH_862/MJ1183", "go_ids": [], "go_terms": [], "name": "MTH_862/MJ1183", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009185": {"description": "Predicted nucleotidyltransferase", "go_ids": [], "go_terms": [], "name": "Nucleotidl_trans", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009186": {"description": "Predicted nickel metalloenzyme maturation factor, AIR synthase-related", "go_ids": [], "go_terms": [], "name": "Ni_metllenz_mat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009187": {"description": "Non-homologous end joining protein Ku, prokaryotic type", "go_ids": [], "go_terms": [], "name": "Prok_Ku", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009188": {"description": "[NiFe]-hydrogenase maturation factor, HypX/HoxX type", "go_ids": [], "go_terms": [], "name": "NiFe-hyd_mat_HypX/HoxX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009190": {"description": "Protein of unknown function DUF1462", "go_ids": [], "go_terms": [], "name": "DUF1462", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009191": {"description": "Diol dehydratase-reactivating factor large subunit", "go_ids": [], "go_terms": [], "name": "DDRA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009192": {"description": "Diol/glycerol dehydratase reactivating factor, small subunit", "go_ids": [], "go_terms": [], "name": "Diol/glycerol_deHydtase_re_ssu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009193": {"description": "Bacterial microcompartment shell protein, EutL/PduB type", "go_ids": ["GO:0031469"], "go_terms": ["GO:0031469:bacterial microcompartment:C"], "name": "EutL_PduB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009194": {"description": "Corrinoid adenosyltransferase EutT", "go_ids": ["GO:0005524", "GO:0006580", "GO:0008817", "GO:0009236"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006580:ethanolamine metabolic process:P", "GO:0008817:corrinoid adenosyltransferase activity:F", "GO:0009236:cobalamin biosynthetic process:P"], "name": "AdoTrfase_EutT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009195": {"description": "Uncharacterised protein family YjbK", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YjbK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009197": {"description": "Microcystin LR degradation protein MlrC", "go_ids": [], "go_terms": [], "name": "MlrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009198": {"description": "Uncharacterised conserved protein UCP014484, transmembrane", "go_ids": [], "go_terms": [], "name": "UCP014484_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009199": {"description": "PhoPQ-activated pathogenicity-related protein, PqaA type", "go_ids": [], "go_terms": [], "name": "PhoPQ-act_pathogen-rel_PqaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009200": {"description": "Protein of unknown function DUF1269, membrane associated", "go_ids": [], "go_terms": [], "name": "DUF1269_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009201": {"description": "Virion core protein, vaccinia E11L type", "go_ids": [], "go_terms": [], "name": "Virion_core", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009203": {"description": "Knr4/Smi1 family", "go_ids": ["GO:0042546"], "go_terms": ["GO:0042546:cell wall biogenesis:P"], "name": "Knr4/Smi1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009205": {"description": "Predicted archaeal flagellar protein C", "go_ids": [], "go_terms": [], "name": "FlaC_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009206": {"description": "Nucleotidase, putative", "go_ids": [], "go_terms": [], "name": "Nucleotidase_putative", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR009207": {"description": "Histone-lysine N-methyltransferase, H3 lysine-37 specific", "go_ids": ["GO:0062122"], "go_terms": ["GO:0062122:histone H3K37 methyltransferase activity:F"], "name": "SET7_MeTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009208": {"description": "Mosquitocidal toxin", "go_ids": [], "go_terms": [], "name": "Mtx2_tox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009209": {"description": "Epsilon-toxin type B", "go_ids": [], "go_terms": [], "name": "EtxB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009210": {"description": "Activating signal cointegrator 1 complex subunit 1", "go_ids": [], "go_terms": [], "name": "ASCC1", "pathway_ids": ["R-HSA-112126"], "pathways": ["R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage"], "type": "Family"}, "IPR009211": {"description": "Type VI secretion system accessory component TagJ", "go_ids": [], "go_terms": [], "name": "TagJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009212": {"description": "Methylthioribose kinase", "go_ids": ["GO:0046522"], "go_terms": ["GO:0046522:S-methyl-5-thioribose kinase activity:F"], "name": "Methylthioribose_kinase", "pathway_ids": ["PWY-6754", "PWY-8131"], "pathways": ["PWY-6754:t:S-methyl-5'-thioadenosine degradation I", "PWY-8131:t:5'-deoxyadenosine degradation II"], "type": "Family"}, "IPR009214": {"description": "Protein of unknown function DUF1129", "go_ids": [], "go_terms": [], "name": "DUF1129", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009215": {"description": "TIM-barrel domain, IGPS-like", "go_ids": [], "go_terms": [], "name": "TIM-br_IGPS-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009216": {"description": "Virulence factor SrfB", "go_ids": [], "go_terms": [], "name": "Virulence_factor_SrfB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009218": {"description": "Predicted HD phosphohydrolase", "go_ids": [], "go_terms": [], "name": "HD_phosphohydro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009219": {"description": "Bacteriophytochrome, CheY-like", "go_ids": [], "go_terms": [], "name": "Bactrphtchr_CheY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009220": {"description": "Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein", "go_ids": ["GO:0004222", "GO:0008270"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0008270:zinc ion binding:F"], "name": "tRNA_threonyl_synthase/kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009221": {"description": "Corrinoid adenosyltransferase PduO", "go_ids": [], "go_terms": [], "name": "PduO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009223": {"description": "Adenomatous polyposis coli protein repeat", "go_ids": ["GO:0016055"], "go_terms": ["GO:0016055:Wnt signaling pathway:P"], "name": "APC_rpt", "pathway_ids": ["R-HSA-5358751", "R-HSA-5358752", "R-HSA-5358749", "R-MMU-3769402", "R-MMU-196299", "R-HSA-3769402", "R-RNO-4641262", "R-HSA-5689896", "R-HSA-5467348", "R-MMU-5689896", "R-HSA-196299", "R-HSA-5467340", "R-RNO-111465", "R-HSA-5358747", "R-RNO-196299", "R-HSA-5339716", "R-HSA-5467337", "R-MMU-4641262", "R-HSA-4641262", "R-HSA-111465", "R-MMU-111465", "R-RNO-3769402", "R-RNO-5689896", "R-HSA-5467333", "R-RNO-195253", "R-MMU-195253", "R-HSA-195253"], "pathways": ["R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467333:r:APC truncation mutants are not K63 polyubiquitinated", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Repeat"}, "IPR009224": {"description": "SAMP", "go_ids": ["GO:0016055", "GO:0008013"], "go_terms": ["GO:0016055:Wnt signaling pathway:P", "GO:0008013:beta-catenin binding:F"], "name": "SAMP", "pathway_ids": ["R-HSA-5358751", "R-HSA-5358752", "R-HSA-5358749", "R-MMU-3769402", "R-MMU-196299", "R-HSA-3769402", 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tumor domain proteases", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467333:r:APC truncation mutants are not K63 polyubiquitinated", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Repeat"}, "IPR009225": {"description": "Bacteriophage head completion protein GpL", "go_ids": ["GO:0019069"], "go_terms": ["GO:0019069:viral capsid assembly:P"], "name": "Phage_head_completion_GpL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009226": {"description": "Penaeidin", "go_ids": ["GO:0005737", "GO:0008061", "GO:0098542"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008061:chitin binding:F", "GO:0098542:defense response to other organism:P"], "name": "Penaeidin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009227": {"description": "Zea mays MURB-like", "go_ids": [], "go_terms": [], "name": "Zea_mays_MuDR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009228": {"description": "Capsid scaffolding protein GpO", "go_ids": ["GO:0019069"], 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["R-HSA-72163", "R-RNO-72163", "R-DME-72163", "R-DDI-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR009270": {"description": "Domain of unknown function DUF927", "go_ids": [], "go_terms": [], "name": "DUF927", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009271": {"description": "Coagulation factor V, LSPD", "go_ids": ["GO:0007596"], "go_terms": ["GO:0007596:blood coagulation:P"], "name": "Coagulation_factor_V_LSPD", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009272": {"description": "Protein of unknown function DUF929", "go_ids": [], "go_terms": [], "name": "DUF929", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009273": {"description": "Protein of unknown function DUF930", "go_ids": [], "go_terms": [], "name": "DUF930", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009274": {"description": "Host-nuclease inhibitor Gam", "go_ids": ["GO:0060703"], "go_terms": ["GO:0060703:deoxyribonuclease inhibitor activity:F"], "name": "Gam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009275": {"description": "SepZ", "go_ids": [], "go_terms": [], "name": "SepZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009278": {"description": "Herpesvirus US9", "go_ids": ["GO:0075733"], "go_terms": ["GO:0075733:intracellular transport of virus:P"], "name": "Herpes_US9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009279": {"description": "Portal protein, Mu bacteriophage", "go_ids": [], "go_terms": [], "name": "Portal_Mu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009280": {"description": "Orthopoxvirus F14", "go_ids": [], "go_terms": [], "name": "Orthopox_F14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009281": {"description": "Transmembrane protein 176A/B", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TMEM176A/TMEM176B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009282": {"description": "Protein of unknown function DUF937", "go_ids": [], "go_terms": [], "name": "DUF937", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009283": {"description": "Apyrase", "go_ids": ["GO:0017110", "GO:0005509"], "go_terms": ["GO:0017110:nucleoside diphosphate phosphatase activity:F", "GO:0005509:calcium ion binding:F"], "name": "Apyrase", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR009284": {"description": "Cytomegalovirus TRL10", "go_ids": [], "go_terms": [], "name": "Cytomega_TRL10", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR009285": {"description": "Poxvirus A26L-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Poxvirus_A26L-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009286": {"description": "Inositol-pentakisphosphate 2-kinase", "go_ids": ["GO:0005524", "GO:0035299"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0035299:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity:F"], "name": "Ins_P5_2-kin", "pathway_ids": ["PWY-6554", "PWY-6362", "PWY-6369", "PWY-6372", "PWY-4661", "PWY-6361", "R-RNO-1855191", "R-DRE-1855191", "R-RNO-1855167", "R-MMU-1855167", "R-MMU-1855191", "R-HSA-1855167", "R-HSA-1855191", "R-DRE-1855167"], "pathways": ["PWY-6554:t:1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)", "PWY-6362:t:1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-6372:t:1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)", "PWY-4661:t:1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)", "PWY-6361:t:1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)", "R-RNO-1855191:r:Synthesis of IPs in the nucleus", "R-DRE-1855191:r:Synthesis of IPs in the nucleus", "R-RNO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855191:r:Synthesis of IPs in the nucleus", "R-HSA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-1855191:r:Synthesis of IPs in the nucleus", "R-DRE-1855167:r:Synthesis of pyrophosphates in the cytosol"], "type": "Family"}, "IPR009287": {"description": "Transcription initiation Spt4", "go_ids": ["GO:0006355", "GO:0005634", "GO:0008270", "GO:0140673"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0005634:nucleus:C", "GO:0008270:zinc ion binding:F", "GO:0140673:transcription elongation-coupled chromatin remodeling:P"], "name": "Spt4", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-HSA-167238", "R-MMU-113418", "R-DME-6796648", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-DRE-6807505", "R-HSA-167287", "R-DRE-75955", "R-HSA-167246", "R-DRE-6796648", "R-DRE-113418", "R-HSA-167152", "R-HSA-113418", "R-SPO-6796648", "R-SCE-6796648", "R-SPO-113418", "R-DME-113418", "R-CEL-75955", "R-MMU-6796648", "R-DME-674695", "R-HSA-167243", "R-SCE-113418", "R-HSA-167242", "R-CEL-113418", "R-MMU-674695", "R-MMU-6807505", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-HSA-167290", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-SCE-674695", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Family"}, "IPR009288": {"description": "Gamma-glutamylcyclotransferase, AIG2-like domain", "go_ids": [], "go_terms": [], "name": "AIG2-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009289": {"description": "Baculoviridae 8.2kDa", "go_ids": [], "go_terms": [], "name": "Baculo_8kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009290": {"description": "Radial spoke 3", "go_ids": [], "go_terms": [], "name": "Radial_spoke_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009291": {"description": "Vacuolar protein sorting-associated protein 62", "go_ids": [], "go_terms": [], "name": "Vps62", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009292": {"description": "rRNA biogenesis protein RRP36", "go_ids": [], "go_terms": [], "name": "RRP36", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-SPO-6791226", "R-DDI-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR009293": {"description": 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"R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-HSA-193692:r:Regulated proteolysis of p75NTR"], "type": "Family"}, "IPR009295": {"description": "S. aureus uracil DNA glycosylase inhibitor", "go_ids": [], "go_terms": [], "name": "SAUGI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009296": {"description": "Protein of unknown function DUF951", "go_ids": [], "go_terms": [], "name": "DUF951", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009297": {"description": "Protein of unknown function DUF952", "go_ids": [], "go_terms": [], "name": "DUF952", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009299": {"description": "Gammaherpesvirus capsid", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Herpes_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009300": {"description": "Transcription activator RinB", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Transcription_activator_RinB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009302": {"description": "Tail length tape measure", "go_ids": [], "go_terms": [], "name": "Tail_length_tape_measure", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009303": {"description": "Protein of unknown function DUF960", "go_ids": [], "go_terms": [], "name": "DUF960", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009304": {"description": "Protein K15", "go_ids": [], "go_terms": [], "name": "K15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009305": {"description": "2-hydroxy-palmitic acid dioxygenase Mpo1-like", "go_ids": [], "go_terms": [], "name": "Mpo1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009306": {"description": "Protein of unknown function DUF963", "go_ids": [], "go_terms": [], "name": "DUF963", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009307": {"description": "Bacterial microcompartment shell protein EutS/PduU/CutR", "go_ids": ["GO:0031469"], "go_terms": ["GO:0031469:bacterial microcompartment:C"], "name": "EutS/PduU/CutR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009308": {"description": "Rhamnose isomerase", "go_ids": ["GO:0008740", "GO:0030145"], "go_terms": ["GO:0008740:L-rhamnose isomerase activity:F", "GO:0030145:manganese ion binding:F"], "name": "Rhamnose_isomerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009309": {"description": "IreB regulatory phosphoprotein-like", "go_ids": [], "go_terms": [], "name": "IreB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009310": {"description": "BphX-like", "go_ids": [], "go_terms": [], "name": "BphX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009311": {"description": "Interferon alpha-inducible protein IFI6/IFI27-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "IFI6/IFI27-like", "pathway_ids": ["R-HSA-909733", "R-BTA-9909505", "R-HSA-9909505"], "pathways": ["R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes"], "type": "Family"}, "IPR009312": {"description": "Minor tail protein U-like", "go_ids": [], "go_terms": [], "name": "Phage_lambda_GpU-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009313": {"description": "Baculovirus 11kDa", "go_ids": [], "go_terms": [], "name": "Baculo_11_kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009314": {"description": "Coronavirus nonstructural NS1", "go_ids": [], "go_terms": [], "name": "Corona_NS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009315": {"description": "Phosphate-starvation-induced PsiE", "go_ids": ["GO:0016020", "GO:0016036"], "go_terms": ["GO:0016020:membrane:C", "GO:0016036:cellular response to phosphate starvation:P"], "name": "P_starv_induced_PsiE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009316": {"description": "COG complex component, COG2", "go_ids": ["GO:0007030", "GO:0015031", "GO:0016020"], "go_terms": ["GO:0007030:Golgi organization:P", "GO:0015031:protein transport:P", "GO:0016020:membrane:C"], "name": "COG2", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-CEL-6811438", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Family"}, "IPR009317": {"description": "ChaB", "go_ids": [], "go_terms": [], "name": "ChaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009318": {"description": "Gustatory receptor", "go_ids": ["GO:0050912", "GO:0008527", "GO:0016020"], "go_terms": ["GO:0050912:detection of chemical stimulus involved in sensory perception of taste:P", "GO:0008527:taste receptor activity:F", "GO:0016020:membrane:C"], "name": "Gustatory_rcpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009319": {"description": "Lactococcus phage , Structural protein", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Phage_A118_VSP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009320": {"description": "Antitoxin CbeA", "go_ids": ["GO:0051495"], "go_terms": ["GO:0051495:positive regulation of cytoskeleton organization:P"], "name": "Antitoxin_CbeA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009321": {"description": "Protein of unknown function DUF973", "go_ids": [], "go_terms": [], "name": "DUF973", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009323": {"description": "Protein of unknown function DUF979", "go_ids": [], "go_terms": [], "name": "DUF979", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009324": {"description": "Protein of unknown function DUF981", "go_ids": [], "go_terms": [], "name": "DUF981", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009325": {"description": "Protein of unknown function DUF983", "go_ids": [], "go_terms": [], "name": "DUF983", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009326": {"description": "Protein of unknown function DUF984", "go_ids": [], "go_terms": [], "name": "DUF984", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009327": {"description": "Cupin domain of unknown function DUF985", "go_ids": [], "go_terms": [], "name": "Cupin_DUF985", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009328": {"description": "Protein of unknown function DUF986", "go_ids": [], "go_terms": [], "name": "DUF986", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009329": {"description": "Uncharacterized protein YeeT", "go_ids": [], "go_terms": [], "name": "YeeT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009330": {"description": "Lipopolysaccharide core heptose(II) kinase", "go_ids": [], "go_terms": [], "name": "WaaY", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR009331": {"description": "Oligogalacturonate-specific porin", "go_ids": [], "go_terms": [], "name": "Oligogalacturonate-sp_porin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009332": {"description": "Mediator of RNA polymerase II transcription subunit 22", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Med22", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR009333": {"description": "Protein of unknown function DUF992", "go_ids": [], "go_terms": [], "name": "DUF992", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009334": {"description": "Protein of unknown function DUF993", "go_ids": [], "go_terms": [], "name": "DUF993", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009335": {"description": "Type III secretion system HrpE /V-type ATP synthase subunit E", "go_ids": [], "go_terms": [], "name": "T3SS_HrpE/ATPase_suE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009337": {"description": "Protein of unknown function DUF995", "go_ids": [], "go_terms": [], "name": "DUF995", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009338": {"description": "Protein of unknown function Orf51", "go_ids": [], "go_terms": [], "name": "Orf51", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009339": {"description": "Protein of unknown function DUF998", "go_ids": [], "go_terms": [], "name": "DUF998", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009340": {"description": "Protein of unknown function DUF999", "go_ids": [], "go_terms": [], "name": "DUF999", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009343": {"description": "Protein of unknown function DUF1002", "go_ids": [], "go_terms": [], "name": "DUF1002", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009344": {"description": "Borna disease virus G", "go_ids": [], "go_terms": [], "name": "BDV_G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009345": {"description": "BMP and activin membrane-bound inhibitor", "go_ids": ["GO:0030512", "GO:0090263"], "go_terms": ["GO:0030512:negative regulation of transforming growth factor beta receptor signaling pathway:P", "GO:0090263:positive regulation of canonical Wnt signaling pathway:P"], "name": "BAMBI", "pathway_ids": ["R-HSA-2173788", "R-RNO-2173788", "R-MMU-2173788"], "pathways": ["R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling"], "type": "Family"}, "IPR009346": {"description": "GRIM-19", "go_ids": [], "go_terms": [], "name": "GRIM-19", "pathway_ids": ["R-HSA-611105", "R-MMU-9837999", "R-MMU-6799198", "R-BTA-9837999", "R-HSA-6799198", "R-MMU-611105", "R-HSA-9837999", "R-BTA-6799198", "R-BTA-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6799198:r:Complex I biogenesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR009347": {"description": "Rice tungro bacilliform virus P46", "go_ids": [], "go_terms": [], "name": "RTBV_P46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009348": {"description": "Nitrogen permease regulator 2-like", "go_ids": [], "go_terms": [], "name": "NPR2-like", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR009349": {"description": "TRIP4/RQT4, C2HC5-type zinc finger", "go_ids": ["GO:0072344", "GO:0180022", "GO:0005634", "GO:0008270"], "go_terms": ["GO:0072344:rescue of stalled cytosolic ribosome:P", "GO:0180022:RQC-trigger complex:C", "GO:0005634:nucleus:C", "GO:0008270:zinc ion binding:F"], "name": "TRIP4/RQT4_C2HC5_Znf", "pathway_ids": ["R-MMU-9954716", "R-HSA-9954716"], "pathways": ["R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "type": "Domain"}, "IPR009350": {"description": "Minor tail T", "go_ids": [], "go_terms": [], "name": "Phage_tail_T", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009351": {"description": "DNA glycosylase AlkZ-like", "go_ids": [], "go_terms": [], "name": "AlkZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009353": {"description": "Orthopoxvirus, Protein N1", "go_ids": ["GO:0052150", "GO:0052031"], "go_terms": ["GO:0052150:symbiont-mediated perturbation of host apoptosis:P", "GO:0052031:symbiont-mediated perturbation of host defense response:P"], "name": "Orthopox_N1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009354": {"description": "Usg-like", "go_ids": [], "go_terms": [], "name": "Usg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009355": {"description": "Toluene-4-monooxygenase system B", "go_ids": [], "go_terms": [], "name": "Toluene_mOase_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009356": {"description": "NADH dehydrogenase subunit 4L", "go_ids": [], "go_terms": [], "name": "NAD_DH_su4L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009357": {"description": "Solute carrier family 52, riboflavin transporter", "go_ids": ["GO:0032218", "GO:0032217", "GO:0005886"], "go_terms": ["GO:0032218:riboflavin transport:P", "GO:0032217:riboflavin transmembrane transporter activity:F", "GO:0005886:plasma membrane:C"], "name": "Riboflavin_transptr", "pathway_ids": ["R-DRE-196843", "R-RNO-196843", "R-BTA-196843", "R-HSA-196843", "R-CEL-196843", "R-MMU-196843"], "pathways": ["R-DRE-196843:r:Vitamin B2 (riboflavin) metabolism", "R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-BTA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-CEL-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism"], "type": "Family"}, "IPR009359": {"description": "1,2-phenylacetyl-CoA epoxidase, subunit B", "go_ids": [], "go_terms": [], "name": "PaaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009360": {"description": "Pre-mRNA-splicing factor Isy1", "go_ids": ["GO:0000350"], "go_terms": ["GO:0000350:generation of catalytic spliceosome for second transesterification step:P"], "name": "Isy1", "pathway_ids": ["R-DDI-6782135", "R-RNO-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-72163", "R-RNO-6782135", "R-DDI-6781823", "R-RNO-72163", "R-DDI-6782210", "R-HSA-6782135", "R-CEL-6782210", "R-DDI-72163", "R-HSA-6781823", "R-CEL-6781823", "R-RNO-6782210", "R-HSA-72163", "R-MMU-6781823", "R-SPO-6782210", "R-CEL-6782135", "R-HSA-6782210", "R-MMU-6782210", "R-SPO-6782135", "R-CEL-72163", "R-SCE-6782210", "R-SPO-72163", "R-HSA-9918481", "R-SCE-6782135"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Family"}, "IPR009361": {"description": "Centromere/kinetochore protein zw10, N-terminal", "go_ids": ["GO:0000775", "GO:0005634", "GO:0000278"], "go_terms": ["GO:0000775:chromosome, centromeric region:C", "GO:0005634:nucleus:C", "GO:0000278:mitotic cell cycle:P"], "name": "Zw10_N", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-6811434", "R-RNO-2500257", "R-MMU-2467813", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-RNO-5663220", "R-DME-6811434", "R-HSA-6811434", "R-HSA-68877", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-MMU-9648025", "R-CEL-6811434", "R-MMU-5663220", "R-RNO-141444", "R-MMU-6811434"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR009362": {"description": "YhcG PDDEXK nuclease domain", "go_ids": [], "go_terms": [], "name": "YhcG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009363": {"description": "Bacteriophage Mu, Gp16", "go_ids": [], "go_terms": [], "name": "Phage_Mu_Gp16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009364": {"description": "YdaT-like", "go_ids": [], "go_terms": [], "name": "YdaT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009365": {"description": "Nucleopolyhedrovirus LEF-12", "go_ids": [], "go_terms": [], "name": "Nucleo_LEF-12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009366": {"description": "Protein Veg", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Protein_Veg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009367": {"description": "Mitochondrial fission protein ELM1-like", "go_ids": [], "go_terms": [], "name": "Elm1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009368": {"description": "Protein of unknown function DUF1024", "go_ids": [], "go_terms": [], "name": "DUF1024", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009369": {"description": "Actinobacillus actinomycetemcomitans leukotoxin activator LktC", "go_ids": [], "go_terms": [], "name": "LktC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009370": {"description": "YutD-like", "go_ids": [], "go_terms": [], "name": "YutD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009371": {"description": "Type III secretion protein HrpF", "go_ids": [], "go_terms": [], "name": "T3SS_HrpF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009372": {"description": "Poxvirus virion membrane protein A14.5", "go_ids": [], "go_terms": [], "name": "Poxvirus_A14.5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009373": {"description": "Circovirus 2, Orf5", "go_ids": [], "go_terms": [], "name": "Circovirus2_Orf5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009374": {"description": "Eukaryotic translation initiation factor 3 subunit K", "go_ids": ["GO:0003743", "GO:0005737", "GO:0005852"], "go_terms": ["GO:0003743:translation initiation factor activity:F", "GO:0005737:cytoplasm:C", "GO:0005852:eukaryotic translation initiation factor 3 complex:C"], "name": "eIF3k", "pathway_ids": ["R-CEL-72689", "R-DME-156827", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-XTR-72702", "R-CEL-72695", "R-MMU-72649", "R-HSA-72695", "R-BTA-72689", "R-MMU-72706", "R-BTA-72695", "R-MMU-72695", "R-XTR-72695", "R-DRE-156827", "R-DME-72695", "R-BTA-156827", "R-MMU-72702", "R-DRE-72695", "R-DDI-72695", "R-XTR-156827", "R-BTA-72702", "R-DME-72689", "R-HSA-72706", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-CEL-156827", "R-DRE-72649", "R-DRE-72702", "R-DRE-72689", "R-CEL-72649", "R-DME-72702", "R-BTA-72649", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": ["R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72649:r:Translation initiation complex formation", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Family"}, "IPR009376": {"description": "Protein of unknown function DUF1031", "go_ids": [], "go_terms": [], "name": "DUF1031", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009377": {"description": "Ethanolamine ammonia-lyase reactivase EutA", "go_ids": [], "go_terms": [], "name": "EutA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009378": {"description": "Condensin II complex subunit H2, N-terminal", "go_ids": [], "go_terms": [], "name": "H2_N", "pathway_ids": ["R-XTR-2299718", "R-CEL-2299718", "R-RNO-2299718", "R-HSA-2299718", "R-BTA-2299718", "R-MMU-2299718", "R-DRE-2299718"], "pathways": ["R-XTR-2299718:r:Condensation of Prophase Chromosomes", "R-CEL-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-BTA-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-DRE-2299718:r:Condensation of Prophase Chromosomes"], "type": "Domain"}, "IPR009379": {"description": "Structural protein VP1/VP3", "go_ids": ["GO:0005198", "GO:0016020"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0016020:membrane:C"], "name": "VP1_VP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009380": {"description": "Protein of unknown function DUF1036", "go_ids": [], "go_terms": [], "name": "DUF1036", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009381": {"description": "Trehalose catabolism protein, ThuA, prokaryote", "go_ids": [], "go_terms": [], "name": "Trehalose_catabolism_ThuA_prok", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009382": {"description": "Coleoptericin", "go_ids": ["GO:0005576", "GO:0042742"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042742:defense response to bacterium:P"], "name": "Coleoptericin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009383": {"description": "Protein of unknown function DUF1040", "go_ids": [], "go_terms": [], "name": "DUF1040", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009384": {"description": "Swarming motility protein SwrD-like", "go_ids": [], "go_terms": [], "name": "SwrD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009385": {"description": "Protein PsiB", "go_ids": [], "go_terms": [], "name": "Plasmid_inh_PsiB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009386": {"description": "Z-ring associated protein G-like", "go_ids": [], "go_terms": [], "name": "ZapG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009387": {"description": "Toxin HigB-2", "go_ids": [], "go_terms": [], "name": "HigB-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009388": {"description": "Photosystem II PsbY", "go_ids": ["GO:0009523", "GO:0015979", "GO:0016020", "GO:0030145"], "go_terms": ["GO:0009523:photosystem II:C", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C", "GO:0030145:manganese ion binding:F"], "name": "PSII_PsbY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009389": {"description": "Protein of unknown function DUF1045", "go_ids": [], "go_terms": [], "name": "DUF1045", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009390": {"description": "Macrodomain Ter protein, MatP", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "MatP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009391": {"description": "23S rRNA methylase leader peptide", "go_ids": ["GO:0046677"], "go_terms": ["GO:0046677:response to antibiotic:P"], "name": "ErmCL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009392": {"description": "Drosophila ACP53EA", "go_ids": [], "go_terms": [], "name": "ACP53EA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009394": {"description": "DNA repair protein MmcB-like", "go_ids": [], "go_terms": [], "name": "MmcB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009395": {"description": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "go_ids": ["GO:0031083"], "go_terms": ["GO:0031083:BLOC-1 complex:C"], "name": "BLOC1S1", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-DME-432720", "R-XTR-432720", "R-RNO-432720", "R-BTA-432720", "R-HSA-432720", "R-CEL-432720", "R-MMU-432722", "R-BTA-432722", "R-MMU-432720", "R-HSA-432722", "R-RNO-432722"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-XTR-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR009396": {"description": "Pigment-dispersing hormone", "go_ids": ["GO:0005179", "GO:0005576", "GO:0009416"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C", "GO:0009416:response to light stimulus:P"], "name": "Pigment_DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009397": {"description": "Vesiculovirus matrix", "go_ids": ["GO:0005198", "GO:0019031"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019031:viral envelope:C"], "name": "Vesiculo_matrix", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009398": {"description": "Adenylate cyclase, conserved domain", "go_ids": ["GO:0004016", "GO:0006171", "GO:0005886"], "go_terms": ["GO:0004016:adenylate cyclase activity:F", "GO:0006171:cAMP biosynthetic process:P", "GO:0005886:plasma membrane:C"], "name": "Adcy_conserved_dom", "pathway_ids": ["R-HSA-9634597", "R-RNO-418597", "R-DME-170670", "R-MMU-418597", "R-RNO-5610787", "R-HSA-9664323", "R-RNO-400042", "R-HSA-432040", "R-DME-170660", "R-HSA-5610787", "R-HSA-442720", "R-DME-163615", "R-HSA-170660", "R-MMU-5610787", "R-MMU-163615", "R-DME-5610787", "R-MMU-400042", "R-HSA-163359", "R-HSA-9660821", "R-DME-418597", "R-RNO-170660", "R-HSA-418555", "R-HSA-400042", "R-RNO-163615", "R-HSA-418594", "R-HSA-381676", "R-MMU-170660", "R-HSA-164378", "R-HSA-418597", "R-HSA-170670", "R-MMU-170670", "R-HSA-9856530", "R-HSA-163615", "R-RNO-170670"], "pathways": ["R-HSA-9634597:r:GPER1 signaling", "R-RNO-418597:r:G alpha (z) signalling events", "R-DME-170670:r:Adenylate cyclase inhibitory pathway", "R-MMU-418597:r:G alpha (z) signalling events", "R-RNO-5610787:r:Hedgehog 'off' state", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-170660:r:Adenylate cyclase activating pathway", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DME-163615:r:PKA activation", "R-HSA-170660:r:Adenylate cyclase activating pathway", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-163615:r:PKA activation", "R-DME-5610787:r:Hedgehog 'off' state", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-DME-418597:r:G alpha (z) signalling events", "R-RNO-170660:r:Adenylate cyclase activating pathway", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-RNO-163615:r:PKA activation", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-170660:r:Adenylate cyclase activating pathway", "R-HSA-164378:r:PKA activation in glucagon signalling", "R-HSA-418597:r:G alpha (z) signalling events", "R-HSA-170670:r:Adenylate cyclase inhibitory pathway", "R-MMU-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-163615:r:PKA activation", "R-RNO-170670:r:Adenylate cyclase inhibitory pathway"], "type": "Domain"}, "IPR009400": {"description": "TFIIH subunit TTDA/Tfb5", "go_ids": ["GO:0006367", "GO:0006289", "GO:0000439"], "go_terms": ["GO:0006367:transcription initiation at RNA polymerase II promoter:P", "GO:0006289:nucleotide-excision repair:P", "GO:0000439:transcription factor TFIIH core complex:C"], "name": "TFIIH_TTDA/Tfb5", "pathway_ids": ["R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-MMU-113418", "R-HSA-427413", "R-BTA-76042", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-HSA-167246", "R-MMU-5696395", "R-SPO-5696395", "R-HSA-73776", "R-SPO-76042", "R-BTA-77075", "R-DDI-674695", "R-HSA-75953", "R-CEL-75953", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-CEL-73776", "R-MMU-76042", "R-SPO-75953", "R-BTA-73863", "R-BTA-75955", "R-SPO-113418", "R-BTA-75953", "R-DDI-73779", "R-BTA-72086", "R-BTA-6782135", "R-DDI-6781823", "R-DDI-72086", "R-CEL-113418", "R-CEL-6782210", "R-MMU-674695", "R-SCE-76042", "R-CEL-6781823", "R-HSA-167161", "R-CEL-674695", "R-HSA-167200", "R-CEL-112382", "R-CEL-6782135", "R-SCE-674695", "R-DDI-77075", "R-HSA-167160", "R-HSA-5696395", "R-CEL-5696395", "R-DDI-113418", "R-BTA-6782210", "R-MMU-73772", "R-MMU-6782210", "R-MMU-72086", "R-SPO-73779", "R-BTA-73776", "R-BTA-73772", "R-SPO-73776", "R-CEL-6796648", "R-SCE-73776", "R-SCE-6782135", "R-DDI-6782135", "R-MMU-73762", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-BTA-113418", "R-CEL-72086", "R-HSA-72086", "R-CEL-73772", "R-HSA-167162", "R-BTA-6781823", "R-MMU-6781823", "R-GGA-353303", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696395", "R-BTA-5696400", "R-SCE-6782210", "R-HSA-167172", "R-BTA-6796648", "R-MMU-5696400", "R-BTA-73779", "R-SCE-6796648", "R-BTA-73762", "R-SCE-73779", "R-SPO-77075", "R-CEL-75955", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-SCE-6781823", "R-MMU-73863", "R-HSA-6782135", "R-BTA-674695", "R-HSA-73762", "R-CEL-77075", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-SCE-77075", "R-SPO-5696400", "R-SPO-6782210", "R-HSA-5696400", "R-DDI-75953", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-SPO-6782135", "R-CEL-76042", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II 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"R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-353303:r:Nucleotide Excision Repair", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR009401": {"description": "Mediator complex subunit Med13, C-terminal", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Med13_C", "pathway_ids": ["R-HSA-1989781", "R-DME-9841922", "R-HSA-381340", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "type": "Domain"}, "IPR009402": {"description": "Orthopoxvirus A47", "go_ids": [], "go_terms": [], "name": "Orthopox_A47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009403": {"description": "Protein of unknown function UPF0637", "go_ids": [], "go_terms": [], "name": "UPF0637", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009404": {"description": "Coronavirus 5a", "go_ids": [], "go_terms": [], "name": "Corona_5a", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009405": {"description": "Vibrio cholerae toxin co-regulated pilus biosynthesis F", "go_ids": [], "go_terms": [], "name": "TcpF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009406": {"description": "Protein of unknown function DUF1056", "go_ids": [], "go_terms": [], "name": "DUF1056", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009407": {"description": "Viral polyprotein, parechovirus P3B", "go_ids": [], "go_terms": [], "name": "VPP_parechovir_P3B", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR009409": {"description": "Protein of unknown function DUF1059", "go_ids": [], "go_terms": [], "name": "DUF1059", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009410": {"description": "Allene oxide cyclase", "go_ids": ["GO:0016853"], "go_terms": ["GO:0016853:isomerase activity:F"], "name": "Allene_ox_cyc", "pathway_ids": ["PWY-735"], "pathways": ["PWY-735:t:jasmonic acid biosynthesis"], "type": "Family"}, "IPR009412": {"description": "Protein of unknown function DUF1062", "go_ids": [], "go_terms": [], "name": "DUF1062", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009413": {"description": "Hemolysin, aegerolysin type", "go_ids": ["GO:0019836"], "go_terms": ["GO:0019836:symbiont-mediated hemolysis of host erythrocyte:P"], "name": "Aegerolysin-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009414": {"description": "Protein of unknown function DUF1064", "go_ids": [], "go_terms": [], "name": "DUF1064", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009415": {"description": "Omega-atracotoxin", "go_ids": ["GO:0005576", "GO:0019855", "GO:0006952"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019855:calcium channel inhibitor activity:F", "GO:0006952:defense response:P"], "name": "Omega-atracotox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009416": {"description": "ESAT-6-like protein, Mycobacterium", "go_ids": [], "go_terms": [], "name": "ESAT-6-like_Myco", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009417": {"description": "Rice tungro bacilliform virus P12", "go_ids": [], "go_terms": [], "name": "RTBV_P12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009419": {"description": "Viral polyprotein, parechovirus P3A", "go_ids": ["GO:0044423"], "go_terms": ["GO:0044423:virion component:C"], "name": "VPP_parechovir_P3A", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR009420": {"description": "Flagellar protein FlhE", "go_ids": [], "go_terms": [], "name": "FlhE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009422": {"description": "Gem-associated protein 6", "go_ids": ["GO:0000245", "GO:0005634"], "go_terms": ["GO:0000245:spliceosomal complex assembly:P", "GO:0005634:nucleus:C"], "name": "Gemin6", "pathway_ids": ["R-BTA-191859", "R-MMU-191859", "R-HSA-9754678", "R-HSA-191859"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-MMU-191859:r:snRNP Assembly", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-191859:r:snRNP Assembly"], "type": "Family"}, "IPR009423": {"description": "NADH dehydrogenase [ubiquinone] 1 subunit C2, NDUC2", "go_ids": ["GO:0005743", "GO:0006120"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C", "GO:0006120:mitochondrial electron transport, NADH to ubiquinone:P"], "name": "NDUC2", "pathway_ids": ["R-HSA-6798695", "R-HSA-611105", "R-MMU-6799198", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6798695", "R-BTA-6798695", "R-BTA-6799198", "R-BTA-611105"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR009424": {"description": "Arabinogalactan protein 16/20/22/41", "go_ids": [], "go_terms": [], "name": "AGP16/20/22/41", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009425": {"description": "Sak Single Strand Annealing Protein", "go_ids": [], "go_terms": [], "name": "SSAP_Sak", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009426": {"description": "Barley yellow dwarf virus (BYDV), Gp6", "go_ids": [], "go_terms": [], "name": "BYDV_Gp6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009427": {"description": "Uncharacterised conserved protein UCP020357", "go_ids": [], "go_terms": [], "name": "UCP020357", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009428": {"description": "Beta-catenin-interacting ICAT domain", "go_ids": ["GO:0008013"], "go_terms": ["GO:0008013:beta-catenin binding:F"], "name": "ICAT_dom", "pathway_ids": ["R-HSA-3769402", "R-MMU-3769402", "R-BTA-3769402"], "pathways": ["R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-BTA-3769402:r:Deactivation of the beta-catenin transactivating complex"], "type": "Domain"}, "IPR009429": {"description": "Baculovirus LEF-11", "go_ids": ["GO:0019058", "GO:0006355"], "go_terms": ["GO:0019058:viral life cycle:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Baculo_LEF-11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009430": {"description": "Gas vesicle protein L/F", "go_ids": ["GO:0031411", "GO:0031412"], "go_terms": ["GO:0031411:gas vesicle:C", "GO:0031412:gas vesicle organization:P"], "name": "GvpL/GvpF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009431": {"description": "Neuronal vesicle trafficking-associated protein", "go_ids": ["GO:0048268", "GO:0032051", "GO:0016020"], "go_terms": ["GO:0048268:clathrin coat assembly:P", "GO:0032051:clathrin light chain binding:F", "GO:0016020:membrane:C"], "name": "NSG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009432": {"description": "Protein of unknown function DUF1075", "go_ids": [], "go_terms": [], "name": "DUF1075", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009433": {"description": "Filovirus membrane-associated VP24", "go_ids": ["GO:0005198", "GO:0016020", "GO:0016032"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0016020:membrane:C", "GO:0016032:viral process:P"], "name": "Filo_VP24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009434": {"description": "Neuroendocrine secretory protein 55", "go_ids": ["GO:0071107"], "go_terms": ["GO:0071107:response to parathyroid hormone:P"], "name": "NESP55", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009436": {"description": "Type-1 angiotensin II receptor-associated protein", "go_ids": ["GO:0038166"], "go_terms": ["GO:0038166:angiotensin-activated signaling pathway:P"], "name": "AGTRAP", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Family"}, "IPR009437": {"description": "Lamprin", "go_ids": ["GO:0005198", "GO:0031012"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0031012:extracellular matrix:C"], "name": "Lamprin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009438": {"description": "Phytosulfokine", "go_ids": ["GO:0005576", "GO:0008083", "GO:0008283"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0008083:growth factor activity:F", "GO:0008283:cell population proliferation:P"], "name": "Phytosulfokine", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009439": {"description": "Red chlorophyll catabolite reductase", "go_ids": ["GO:0051743"], "go_terms": ["GO:0051743:red chlorophyll catabolite reductase activity:F"], "name": "RCC_reductase", "pathway_ids": ["PWY-5098", "PWY-6927"], "pathways": ["PWY-5098:t:chlorophyll a degradation I", "PWY-6927:t:chlorophyll a degradation II"], "type": "Family"}, "IPR009440": {"description": "Plasmid segregation protein ParM/StbA, N-terminal", "go_ids": [], "go_terms": [], "name": "ParM/StbA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009441": {"description": "P40 nucleoprotein, Borna disease virus", "go_ids": [], "go_terms": [], "name": "P40_nucleoprot_BD-vir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009443": {"description": "Nuclear pore complex interacting protein", "go_ids": [], "go_terms": [], "name": "NPIP", "pathway_ids": ["R-HSA-9692916"], "pathways": ["R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Family"}, "IPR009444": {"description": "Conjugal transfer, TraD, alpha-type", "go_ids": [], "go_terms": [], "name": "Conjugal_tfr_TraD_a-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009445": {"description": "ER membrane protein complex subunit 4", "go_ids": [], "go_terms": [], "name": "TMEM85/Emc4", "pathway_ids": ["R-HSA-9918485"], "pathways": ["R-HSA-9918485:r:Dengue Virus Attachment and Entry"], "type": "Family"}, "IPR009446": {"description": "Mitochondrial genome maintenance protein Mgm101", "go_ids": ["GO:0000262", "GO:0003697", "GO:0006281"], "go_terms": ["GO:0000262:mitochondrial chromosome:C", "GO:0003697:single-stranded DNA binding:F", "GO:0006281:DNA repair:P"], "name": "Mgm101", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009447": {"description": "Phosphatidylinositol anchor biosynthesis protein PIGW/GWT1", "go_ids": ["GO:0006506", "GO:0016020", "GO:0016746"], "go_terms": ["GO:0006506:GPI anchor biosynthetic process:P", "GO:0016020:membrane:C", "GO:0016746:acyltransferase activity:F"], "name": "PIGW/GWT1", "pathway_ids": ["R-SCE-162710", "R-SPO-162710", "R-MMU-162710", "R-HSA-162710", "R-RNO-162710", "R-DDI-162710"], "pathways": ["R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-DDI-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR009448": {"description": "UDP-glucose:Glycoprotein Glucosyltransferase", "go_ids": ["GO:0003980", "GO:0009101"], "go_terms": ["GO:0003980:UDP-glucose:glycoprotein glucosyltransferase activity:F", "GO:0009101:glycoprotein biosynthetic process:P"], "name": "UDP-g_GGtrans", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-901032"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)"], "type": "Family"}, "IPR009449": {"description": "GDP/GTP exchange factor Sec2, N-terminal", "go_ids": [], "go_terms": [], "name": "Sec2_N", "pathway_ids": ["R-SPO-5620912", "R-HSA-5620916", "R-MMU-8876198", "R-SCE-5620912", "R-RNO-5620916", "R-RNO-5620922", "R-RNO-8876198", "R-HSA-5620912", "R-BTA-8876198", "R-HSA-8876198", "R-RNO-5620912", "R-SPO-8876198", "R-SCE-8876198", "R-HSA-5620922"], "pathways": ["R-SPO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR009450": {"description": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "go_ids": ["GO:0006506", "GO:0016020"], "go_terms": ["GO:0006506:GPI anchor biosynthetic process:P", "GO:0016020:membrane:C"], "name": "Plno_GlcNAc_GPI2", "pathway_ids": ["R-SPO-162710", "R-MMU-162710", "R-BTA-162710", "R-HSA-162710", "R-RNO-162710", "R-DDI-162710"], "pathways": ["R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-BTA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-DDI-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR009451": {"description": "Amine dehydrogenase heavy chain", "go_ids": ["GO:0030058", "GO:0042597"], "go_terms": ["GO:0030058:aliphatic amine dehydrogenase activity:F", "GO:0042597:periplasmic space:C"], "name": "Metamine_DH_Hvc", "pathway_ids": ["PWY-6967"], "pathways": ["PWY-6967:t:methylamine degradation I"], "type": "Family"}, "IPR009452": {"description": "Pneumovirus matrix 2-1", "go_ids": ["GO:0005198", "GO:0046782", "GO:0044423"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0046782:regulation of viral transcription:P", "GO:0044423:virion component:C"], "name": "Pneumovirus_M2-1", "pathway_ids": ["R-HSA-9828721", "R-HSA-9833110", "R-HSA-9828806", "R-HSA-9820962", "R-HSA-9828642", "R-HSA-9834752", "R-HSA-9820960"], "pathways": ["R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-9828642:r:Respiratory syncytial virus genome transcription", "R-HSA-9834752:r:Respiratory syncytial virus genome replication", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry"], "type": "Family"}, "IPR009453": {"description": "IMP-specific 5-nucleotidase", "go_ids": ["GO:0006190", "GO:0000287", "GO:0009117", "GO:0008253"], "go_terms": ["GO:0006190:inosine salvage:P", "GO:0000287:magnesium ion binding:F", "GO:0009117:nucleotide metabolic process:P", "GO:0008253:5'-nucleotidase activity:F"], "name": "ISN1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009454": {"description": "Lipid transport, open beta-sheet", "go_ids": ["GO:0005319", "GO:0006869"], "go_terms": ["GO:0005319:lipid carrier activity:F", "GO:0006869:lipid transport:P"], "name": "Lipid_transpt_open_b-sht", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-HSA-8964038", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-RNO-5686938", "R-MMU-3000471", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-HSA-8957275", "R-RNO-3000480", "R-HSA-202733", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964038:r:LDL clearance", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR009455": {"description": "ATP synthase YMF19, uncharacterised, C-terminal", "go_ids": ["GO:0005739", "GO:0016020"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0016020:membrane:C"], "name": "YMF19", "pathway_ids": ["PWY-7980"], "pathways": ["PWY-7980:t:ATP biosynthesis"], "type": "Domain"}, "IPR009456": {"description": "Moricin family", "go_ids": ["GO:0005576", "GO:0042742"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042742:defense response to bacterium:P"], "name": "Moricin_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009457": {"description": "THH1/TOM1/TOM3 domain", "go_ids": [], "go_terms": [], "name": "THH1/TOM1/TOM3_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009458": {"description": "Ectatomin", "go_ids": ["GO:0005216", "GO:0005576"], "go_terms": ["GO:0005216:monoatomic ion channel activity:F", "GO:0005576:extracellular region:C"], "name": "Ectatomin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009459": {"description": "MucBP domain", "go_ids": [], "go_terms": [], "name": "MucBP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009460": {"description": "Ryanodine Receptor TM 4-6", "go_ids": ["GO:0005219", "GO:0006874", "GO:0016020"], "go_terms": ["GO:0005219:ryanodine-sensitive calcium-release channel activity:F", "GO:0006874:intracellular calcium ion homeostasis:P", "GO:0016020:membrane:C"], "name": "Ryanrecept_TM4-6", "pathway_ids": ["R-HSA-5578775", "R-MMU-5578775", "R-RNO-2672351", "R-HSA-2672351", "R-MMU-2672351", "R-RNO-5578775"], "pathways": ["R-HSA-5578775:r:Ion homeostasis", "R-MMU-5578775:r:Ion homeostasis", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-RNO-5578775:r:Ion homeostasis"], "type": "Domain"}, "IPR009461": {"description": "Non-structural protein NSP16, coronavirus-like", "go_ids": [], "go_terms": [], "name": "NSP16_CoV-like", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "PWY-7379", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-191859", "R-HSA-9705671", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7379:t:mRNA capping II", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR009462": {"description": "CHD subfamily II, SANT-like domain", "go_ids": ["GO:0006338", "GO:0003677"], "go_terms": ["GO:0006338:chromatin remodeling:P", "GO:0003677:DNA binding:F"], "name": "CHD_II_SANT-like", "pathway_ids": ["PWY-7250", "R-MMU-73762", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-MMU-9031628", "R-MMU-8943724", "R-DME-3214815", "R-HSA-6804758", "R-CEL-8943724", "R-HSA-9844594", "R-HSA-9845323", "R-HSA-8943724", "R-CEL-4551638", "R-MMU-6804758", "R-DME-6804758", "R-HSA-9843940", "R-DME-9031628", "R-HSA-427389", "R-HSA-9031628", "R-CEL-9031628", "R-HSA-4551638", "R-DME-8943724"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-9031628:r:NGF-stimulated transcription", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-9031628:r:NGF-stimulated transcription", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-8943724:r:Regulation of PTEN gene transcription"], "type": "Domain"}, "IPR009463": {"description": "Domain of unknown function DUF1087", "go_ids": [], "go_terms": [], "name": "DUF1087", "pathway_ids": ["PWY-7250", "R-MMU-73762", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-MMU-9031628", "R-MMU-8943724", "R-DME-3214815", "R-HSA-6804758", "R-CEL-8943724", "R-HSA-9844594", "R-HSA-9845323", "R-HSA-8943724", "R-CEL-4551638", "R-MMU-6804758", "R-DME-6804758", "R-HSA-9843940", "R-DME-9031628", "R-HSA-427389", "R-HSA-9031628", "R-CEL-9031628", "R-HSA-4551638", "R-DME-8943724"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-9031628:r:NGF-stimulated transcription", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-9031628:r:NGF-stimulated transcription", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-8943724:r:Regulation of PTEN gene transcription"], "type": "Domain"}, "IPR009464": {"description": "PCAF, N-terminal", "go_ids": ["GO:0004402", "GO:0005634", "GO:0006355"], "go_terms": ["GO:0004402:histone acetyltransferase activity:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "PCAF_N", "pathway_ids": ["R-HSA-2032785", "R-HSA-5689901", "R-HSA-8941856", "R-HSA-9772755", "R-HSA-5689880", "R-HSA-8936459", "R-DRE-8936459", "R-MMU-2122947", "R-MMU-5689901", "R-MMU-9617629", "R-HSA-1912408", "R-HSA-5578768", "R-MMU-5689880", "R-DRE-2032785", "R-MMU-9772755", "R-HSA-2122947", "R-HSA-9018519", "R-DRE-9018519", "R-HSA-9617629", "R-DRE-5689901", "R-MMU-8936459", "R-DRE-5689880", "R-MMU-5250924", "R-HSA-9013508", "R-HSA-210744", "R-HSA-2894862", "R-HSA-73762", "R-HSA-350054", "R-DRE-5250924", "R-MMU-9018519", "R-HSA-9013695", "R-MMU-350054", "R-HSA-9733709", "R-MMU-8941856", "R-HSA-5250924", "R-HSA-9793380", "R-HSA-3214847", "R-HSA-2644606", "R-MMU-2032785", "R-DRE-9617629"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-5578768:r:Physiological factors", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DRE-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-DRE-5689901:r:Metalloprotease DUBs", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-9733709:r:Cardiogenesis", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-DRE-9617629:r:Regulation of FOXO transcriptional activity by acetylation"], "type": "Domain"}, "IPR009465": {"description": "Spondin, N-terminal", "go_ids": [], "go_terms": [], "name": "Spondin_N", "pathway_ids": ["R-BTA-5173214", "R-RNO-5173214", "R-HSA-5173214", "R-HSA-5083635", "R-MMU-5173214"], "pathways": ["R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Domain"}, "IPR009466": {"description": "Non-structural protein 14, coronavirus", "go_ids": ["GO:0004532", "GO:0008168"], "go_terms": ["GO:0004532:RNA exonuclease activity:F", "GO:0008168:methyltransferase activity:F"], "name": "NSP14_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "PWY-7379", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-191859", "R-HSA-9705671", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7379:t:mRNA capping II", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR009467": {"description": "Putative glycolipid-binding protein", "go_ids": [], "go_terms": [], "name": "Glycolipid-bd_prot_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009468": {"description": "Protein of unknown function DUF1090", "go_ids": [], "go_terms": [], "name": "DUF1090", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009469": {"description": "RNA-dependent RNA polymerase, N-terminal, coronavirus", "go_ids": ["GO:0003723", "GO:0003968", "GO:0005524", "GO:0006351"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0005524:ATP binding:F", "GO:0006351:DNA-templated transcription:P"], "name": "RdRp_N_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "PWY-7379", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-191859", "R-HSA-9705671", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7379:t:mRNA capping II", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR009470": {"description": "Chitinase, C-terminal", "go_ids": [], "go_terms": [], "name": "Chi_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009471": {"description": "Teneurin intracellular, N-terminal", "go_ids": ["GO:0007165", "GO:0016020"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0016020:membrane:C"], "name": "Ten_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009472": {"description": "Tab2-like", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Tab2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009473": {"description": "Orthopoxvirus A49", "go_ids": [], "go_terms": [], "name": "Orthopox_A49", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009474": {"description": "Bacilliredoxins BrxB/BrxA", "go_ids": [], "go_terms": [], "name": "BrxB/BrxA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009475": {"description": "Protein of unknown function DUF1096", "go_ids": [], "go_terms": [], "name": "DUF1096", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009476": {"description": "Protein of unknown function DUF1097", "go_ids": [], "go_terms": [], "name": "DUF1097", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009477": {"description": "Baculovirus Ac102", "go_ids": [], "go_terms": [], "name": "Baculo_Ac102", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009479": {"description": "Human herpesvirus U55", "go_ids": [], "go_terms": [], "name": "Herpes_U55", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009480": {"description": "Equine infectious anaemia virus S2", "go_ids": [], "go_terms": [], "name": "Equine_IAV_S2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009482": {"description": "Protein of unknown function DUF1102", "go_ids": [], "go_terms": [], "name": "DUF1102", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009483": {"description": "Type III secretion systems tip complex component IpaD/BipD/SipD", "go_ids": [], "go_terms": [], "name": "IpaD/BipD/SipD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009484": {"description": "Protein of unknown function DUF1103", "go_ids": [], "go_terms": [], "name": "DUF1103", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009485": {"description": "Borna disease virus P10", "go_ids": [], "go_terms": [], "name": "BDV_P10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009486": {"description": "Purine nucleoside permease", "go_ids": ["GO:0055085"], "go_terms": ["GO:0055085:transmembrane transport:P"], "name": "Pur_nuclsid_perm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009487": {"description": "Orthopoxvirus A43R", "go_ids": [], "go_terms": [], "name": "Orthopox_A43R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009488": {"description": "Protein of unknown function DUF1104", "go_ids": [], "go_terms": [], "name": "DUF1104", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009489": {"description": "PAR1", "go_ids": [], "go_terms": [], "name": "PAR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009490": {"description": "Protein of unknown function DUF1106", "go_ids": [], "go_terms": [], "name": "DUF1106", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009491": {"description": "Protein of unknown function DUF1107", "go_ids": [], "go_terms": [], "name": "DUF1107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009492": {"description": "TniQ", "go_ids": [], "go_terms": [], "name": "TniQ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009493": {"description": "Escherichia phage P2, Tail assembly protein E'", "go_ids": [], "go_terms": [], "name": "P2_GpE'", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009494": {"description": "Protein of unknown function DUF1108", "go_ids": [], "go_terms": [], "name": "DUF1108", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009495": {"description": "Anti-sigma-F factor NrsF", "go_ids": [], "go_terms": [], "name": "NrsF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009496": {"description": "Repulsive guidance molecule, C-terminal", "go_ids": [], "go_terms": [], "name": "RGM_C", "pathway_ids": ["R-HSA-373752"], "pathways": ["R-HSA-373752:r:Netrin-1 signaling"], "type": "Domain"}, "IPR009497": {"description": "Regulator protein, PHA-1", "go_ids": [], "go_terms": [], "name": "Regulator_protein_PHA-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009498": {"description": "Bacteriophage 4268, Orf1, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_4268_Orf1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009499": {"description": "Oxamate carbamoyltransferase subunit AllG-like", "go_ids": [], "go_terms": [], "name": "AllG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009500": {"description": "Protein of unknown function DUF1118", "go_ids": [], "go_terms": [], "name": "DUF1118", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009501": {"description": "Uncharacterised conserved protein UCP020269", "go_ids": [], "go_terms": [], "name": "UCP020269", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009502": {"description": "Secretion monitor", "go_ids": ["GO:0045182"], "go_terms": ["GO:0045182:translation regulator activity:F"], "name": "SecM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009503": {"description": "Protein of unknown function DUF1125", "go_ids": [], "go_terms": [], "name": "DUF1125", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009505": {"description": "Neural chondroitin sulphate proteoglycan cytoplasmic", "go_ids": [], "go_terms": [], "name": "Neural_ProG_Cyt", "pathway_ids": ["R-HSA-2024101", "R-RNO-2022923", "R-HSA-3595174", "R-MMU-2022870", "R-RNO-1971475", "R-HSA-2022923", "R-HSA-2022870", "R-RNO-2024101", "R-HSA-3560783", "R-HSA-4420332", "R-HSA-3595177", "R-MMU-2024101", "R-HSA-1971475", "R-HSA-3595172", "R-MMU-1971475", "R-MMU-2022923", "R-RNO-2022870", "R-HSA-3560801"], "pathways": ["R-HSA-2024101:r:CS/DS degradation", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD"], "type": "Domain"}, "IPR009506": {"description": "YjiS-like domain", "go_ids": [], "go_terms": [], "name": "YjiS-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009507": {"description": "Protein of unknown function UPF0435", "go_ids": [], "go_terms": [], "name": "UPF0435", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009508": {"description": "Transcription activator, Churchill", "go_ids": ["GO:0007275", "GO:0008270", "GO:0045893"], "go_terms": ["GO:0007275:multicellular organism development:P", "GO:0008270:zinc ion binding:F", "GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "Transcrpt_activator_Churchill", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009509": {"description": "Protein of unknown function DUF1132", "go_ids": [], "go_terms": [], "name": "DUF1132", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009510": {"description": "Type III secretion system, secretion protein K", "go_ids": [], "go_terms": [], "name": "T3SS_K", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009511": {"description": "Mad1/Cdc20-bound-Mad2 binding protein", "go_ids": ["GO:0005634", "GO:0007096"], "go_terms": ["GO:0005634:nucleus:C", "GO:0007096:regulation of exit from mitosis:P"], "name": "MAD1/Cdc20-bound-Mad2-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009512": {"description": "Circumsporozoite-related antigen", "go_ids": [], "go_terms": [], "name": "Circumsporozoite-rel_antigen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009513": {"description": "PerB", "go_ids": [], "go_terms": [], "name": "PerB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009514": {"description": "Nucleoid disruption protein", "go_ids": [], "go_terms": [], "name": "Phage_Ndd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009515": {"description": "Protein of unknown function DUF1138", "go_ids": [], "go_terms": [], "name": "DUF1138", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009516": {"description": "Raspberry bushy dwarf virus coat", "go_ids": [], "go_terms": [], "name": "RBDV_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009517": {"description": "Borna disease virus P24", "go_ids": [], "go_terms": [], "name": "BDV_P24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009518": {"description": "Photosystem II PsbX", "go_ids": ["GO:0009523", "GO:0015979", "GO:0016020"], "go_terms": ["GO:0009523:photosystem II:C", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C"], "name": "PSII_PsbX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009519": {"description": "Fiji disease virus, Vp7-2", "go_ids": [], "go_terms": [], "name": "FDV_Vp7-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009520": {"description": "Protein of unknown function DUF1140", "go_ids": [], "go_terms": [], "name": "DUF1140", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009521": {"description": "Orthopoxvirus F6", "go_ids": [], "go_terms": [], "name": "Orthopox_F6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009522": {"description": "Nucleocapsid, Phlebovirus/Tenuivirus", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Capsid_Phlebovir/Tenuivir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009523": {"description": "Prokineticin", "go_ids": [], "go_terms": [], "name": "Prokineticin", "pathway_ids": ["R-MMU-416476", "R-RNO-375276", "R-HSA-375276", "R-MMU-375276", "R-HSA-416476", "R-RNO-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events"], "type": "Family"}, "IPR009524": {"description": "Cilia- and flagella-associated protein 68", "go_ids": ["GO:0005634", "GO:0030317"], "go_terms": ["GO:0005634:nucleus:C", "GO:0030317:flagellated sperm motility:P"], "name": "CFAP68", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009525": {"description": "Protein of unknown function DUF1145", "go_ids": [], "go_terms": [], "name": "DUF1145", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009526": {"description": "Protein of unknown function DUF1146", "go_ids": [], "go_terms": [], "name": "DUF1146", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009527": {"description": "Circovirus 2, Orf1", "go_ids": [], "go_terms": [], "name": "Circovirus2_Orf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009528": {"description": "BsuBI/PstI restriction endonuclease domain", "go_ids": ["GO:0000287", "GO:0003677", "GO:0009036", "GO:0009307"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0003677:DNA binding:F", "GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_II_BsuBI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009529": {"description": "Maize streak virus, 13.1kDa", "go_ids": [], "go_terms": [], "name": "Maize_streak_virus_13.1kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009530": {"description": "Protein of unknown function DUF1149", "go_ids": [], "go_terms": [], "name": "DUF1149", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009531": {"description": "Protein of unknown function DUF1150", "go_ids": [], "go_terms": [], "name": "DUF1150", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009532": {"description": "SepQ/SsaQ, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SepQ/SsaQ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009533": {"description": "FAM107", "go_ids": [], "go_terms": [], "name": "FAM107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009534": {"description": "Protein of unknown function DUF1153", "go_ids": [], "go_terms": [], "name": "DUF1153", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009536": {"description": "Cucumber mosaic virus, OrfIIB", "go_ids": [], "go_terms": [], "name": "CucumberMosaicV_OrfIIB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009537": {"description": "Domain of unknown function DUF1156", "go_ids": [], "go_terms": [], "name": "DUF1156", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009538": {"description": "Plasmalemma vesicle-associated protein", "go_ids": [], "go_terms": [], "name": "PV-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009539": {"description": "Vang-like protein", "go_ids": ["GO:0007275", "GO:0016020"], "go_terms": ["GO:0007275:multicellular organism development:P", "GO:0016020:membrane:C"], "name": "VANGL", "pathway_ids": ["R-HSA-9013409", "R-HSA-9013405", "R-DRE-9696273", "R-MMU-9013106", "R-RNO-9696270", "R-MMU-8980692", "R-MMU-9013408", "R-HSA-9013106", "R-MMU-9013404", "R-HSA-9013424", "R-HSA-9013423", "R-MMU-9013420", "R-DRE-9696264", "R-HSA-9035034", "R-HSA-9013148", "R-XTR-9696264", "R-HSA-9696273", "R-HSA-9013408", "R-DRE-9696270", "R-XTR-9696273", "R-MMU-9035034", "R-MMU-9013407", "R-HSA-9013420", "R-HSA-9696270", "R-HSA-4086400", "R-MMU-9013424", "R-RNO-9696273", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-4608870", "R-MMU-9013406", "R-MMU-9013026", "R-MMU-9013149", "R-RNO-9696264", "R-HSA-9013026", "R-MMU-9696264", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9013407"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DRE-9696273:r:RND1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DRE-9696264:r:RND3 GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-XTR-9696264:r:RND3 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DRE-9696270:r:RND2 GTPase cycle", "R-XTR-9696273:r:RND1 GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-4086400:r:PCP/CE pathway", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR009540": {"description": "Basal layer antifungal peptide", "go_ids": [], "go_terms": [], "name": "BAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009542": {"description": "Signal peptidase complex subunit 1", "go_ids": ["GO:0005787", "GO:0016020", "GO:0051604"], "go_terms": ["GO:0005787:signal peptidase complex:C", "GO:0016020:membrane:C", "GO:0051604:protein maturation:P"], "name": "Spc1/SPCS1", "pathway_ids": ["R-MMU-422085", "R-HSA-1799339", "R-CFA-9768727", "R-HSA-9828806", "R-HSA-9918432", "R-HSA-381771", "R-HSA-9768727", "R-MMU-9768727", "R-CFA-422085", "R-HSA-422085", "R-HSA-400511"], "pathways": ["R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Family"}, "IPR009543": {"description": "Vacuolar protein sorting-associated protein 13, VPS13 adaptor binding domain", "go_ids": [], "go_terms": [], "name": "VPS13_VAB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009544": {"description": "Protein of unknown function DUF1163", "go_ids": [], "go_terms": [], "name": "DUF1163", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009545": {"description": "Tight junction protein, claudin-like", "go_ids": [], "go_terms": [], "name": "Claudin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009547": {"description": "Tenuivirus PVC2", "go_ids": [], "go_terms": [], "name": "Tenui_PVC2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009548": {"description": "PRKR-interacting protein 1", "go_ids": ["GO:0003725"], "go_terms": ["GO:0003725:double-stranded RNA binding:F"], "name": "Prkrip1", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-XTR-72163", "R-CEL-72163", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR009550": {"description": "VirE3", "go_ids": [], "go_terms": [], "name": "VirE3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009551": {"description": "Protein wntless", "go_ids": ["GO:0016055", "GO:0017147"], "go_terms": ["GO:0016055:Wnt signaling pathway:P", "GO:0017147:Wnt-protein binding:F"], "name": "Wntless", "pathway_ids": ["R-RNO-3238698", "R-MMU-3238698", "R-CEL-3238698", "R-DME-3238698", "R-HSA-3238698"], "pathways": ["R-RNO-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-CEL-3238698:r:WNT ligand biogenesis and trafficking", "R-DME-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking"], "type": "Family"}, "IPR009553": {"description": "Protein of unknown function DUF1173", "go_ids": [], "go_terms": [], "name": "DUF1173", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009554": {"description": "Phage shock protein B", "go_ids": ["GO:0009271", "GO:0006355"], "go_terms": ["GO:0009271:phage shock:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Phageshock_PspB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009556": {"description": "Microneme Etmic-2", "go_ids": [], "go_terms": [], "name": "Microneme_Etmic-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009557": {"description": "Repeat of unknown function DUF1174", "go_ids": [], "go_terms": [], "name": "DUF1174", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009558": {"description": "Protein of unknown function DUF1175", "go_ids": [], "go_terms": [], "name": "DUF1175", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009559": {"description": "Lactococcus phage c2, major capsid protein", "go_ids": [], "go_terms": [], "name": "Lactococcus_phage_c2_MCP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009560": {"description": "Protein of unknown function DUF1176", "go_ids": [], "go_terms": [], "name": "DUF1176", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009561": {"description": "Protein of unknown function DUF1177", "go_ids": [], "go_terms": [], "name": "DUF1177", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009562": {"description": "Protein of unknown function DUF1178", "go_ids": [], "go_terms": [], "name": "DUF1178", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009563": {"description": "ZNRD2-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ZNRD2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009564": {"description": "Protein of unknown function DUF1179", "go_ids": [], "go_terms": [], "name": "DUF1179", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009565": {"description": "Membrane protein FAM174-like", "go_ids": [], "go_terms": [], "name": "FAM174-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009566": {"description": "Protein of unknown function DUF1181", "go_ids": [], "go_terms": [], "name": "DUF1181", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009567": {"description": "Store-operated calcium entry-associated regulatory factor", "go_ids": ["GO:0005789", "GO:2001256"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:2001256:regulation of store-operated calcium entry:P"], "name": "SARAF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009568": {"description": "Protein of unknown function DUF1184", "go_ids": [], "go_terms": [], "name": "DUF1184", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009569": {"description": "Amino acid synthesis, putative", "go_ids": [], "go_terms": [], "name": "AA_synth_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009570": {"description": "Stage III sporulation protein AC", "go_ids": [], "go_terms": [], "name": "Spore_III_AC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009571": {"description": "Membrane protein SUR7/Rim9-like, fungi", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "SUR7/Rim9-like_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009572": {"description": "Double-strand break reduction protein", "go_ids": [], "go_terms": [], "name": "RcbA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009573": {"description": "FeGP cofactor biosynthesis protein, methyltransferase HcgC", "go_ids": [], "go_terms": [], "name": "HcgC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009574": {"description": "Protein of unknown function DUF1189", "go_ids": [], "go_terms": [], "name": "DUF1189", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009575": {"description": "Melon necrotic spot virus P7B", "go_ids": [], "go_terms": [], "name": "MNSV_P7B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009576": {"description": "Biofilm formation YgiB", "go_ids": [], "go_terms": [], "name": "Biofilm_formation_YgiB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009577": {"description": "Putative small multi-drug export", "go_ids": [], "go_terms": [], "name": "Sm_multidrug_ex", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009578": {"description": "Cell surface antigen I/II A repeat", "go_ids": [], "go_terms": [], "name": "Surface_Ag_I_II_A_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009579": {"description": "Protein of unknown function DUF1192", "go_ids": [], "go_terms": [], "name": "DUF1192", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009580": {"description": "GPI biosynthesis protein Pig-F", "go_ids": ["GO:0005789", "GO:0006506"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0006506:GPI anchor biosynthetic process:P"], "name": "GPI_biosynthesis_protein_Pig-F", "pathway_ids": ["R-SCE-162710", "R-MMU-162710", "R-HSA-162710", "R-SPO-1660661"], "pathways": ["R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR009581": {"description": "FAM20, C-terminal", "go_ids": [], "go_terms": [], "name": "FAM20_C", "pathway_ids": ["R-DME-381426", "R-DME-8957275", "R-DME-1971475", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-HSA-1971475", "R-HSA-8957275", "R-MMU-1971475", "R-MMU-8957275", "R-HSA-381426", "R-DRE-1971475"], "pathways": ["R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis"], "type": "Domain"}, "IPR009582": {"description": "Signal peptidase complex subunit 2", "go_ids": ["GO:0005787", "GO:0016020", "GO:0051604"], "go_terms": ["GO:0005787:signal peptidase complex:C", "GO:0016020:membrane:C", "GO:0051604:protein maturation:P"], "name": "Spc2/SPCS2", "pathway_ids": ["R-MMU-422085", "R-HSA-1799339", "R-CFA-9768727", "R-HSA-9828806", "R-DRE-9768727", "R-HSA-9918432", "R-DRE-422085", "R-XTR-9768727", "R-HSA-381771", "R-HSA-9768727", "R-MMU-9768727", "R-CFA-422085", "R-HSA-422085", "R-HSA-400511"], "pathways": ["R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DRE-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-XTR-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Family"}, "IPR009584": {"description": "Citrus tristeza virus 6kDa protein", "go_ids": [], "go_terms": [], "name": "CTV_6kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009587": {"description": "Protein of unknown function DUF1198", "go_ids": [], "go_terms": [], "name": "DUF1198", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009588": {"description": "Feline immunodeficiency virus, Orf3", "go_ids": [], "go_terms": [], "name": "FIV_Orf3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009589": {"description": "Uncharacterized protein YyaB-like, PH domain", "go_ids": ["GO:0030153"], "go_terms": ["GO:0030153:bacteriocin immunity:P"], "name": "PH_YyaB-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009590": {"description": "Protein Gp5, N-terminal OB-fold domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Gp5_OB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009591": {"description": "Movement protein p6, Beet yellows virus", "go_ids": [], "go_terms": [], "name": "Beet_yellows_virus_p6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009592": {"description": "Protein of unknown function DUF1202", "go_ids": [], "go_terms": [], "name": "DUF1202", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009593": {"description": "Protein of unknown function DUF1203", "go_ids": [], "go_terms": [], "name": "DUF1203", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009594": {"description": "Transcription regulator HTH, AraC, N-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_HTH_AraC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009595": {"description": "Bacteriophage DNA replication protein Gp16.7", "go_ids": ["GO:0039693"], "go_terms": ["GO:0039693:viral DNA genome replication:P"], "name": "Phage_DNA_replic_GP16.7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009596": {"description": "Domain of unknown function DUF1204", "go_ids": [], "go_terms": [], "name": "DUF1204", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009597": {"description": "Domain of unknown function DUF1206", "go_ids": [], "go_terms": [], "name": "DUF1206", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009598": {"description": "Apoptosis inducing factor BLCAP", "go_ids": [], "go_terms": [], "name": "BCALP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009599": {"description": "Protein of unknown function DUF1207", "go_ids": [], "go_terms": [], "name": "DUF1207", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009600": {"description": "GPI transamidase subunit PIG-U", "go_ids": ["GO:0016020", "GO:0016255", "GO:0042765"], "go_terms": ["GO:0016020:membrane:C", "GO:0016255:attachment of GPI anchor to protein:P", "GO:0042765:GPI-anchor transamidase complex:C"], "name": "PIG-U", "pathway_ids": ["R-MMU-162791", "R-HSA-162791", "R-RNO-162791"], "pathways": ["R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-HSA-162791:r:Attachment of GPI anchor to uPAR", "R-RNO-162791:r:Attachment of GPI anchor to uPAR"], "type": "Family"}, "IPR009601": {"description": "Centromere protein R", "go_ids": ["GO:0034080", "GO:0006355"], "go_terms": ["GO:0034080:CENP-A containing chromatin assembly:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "CENP-R", "pathway_ids": ["R-HSA-606279", "R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-RNO-2500257", "R-HSA-205043", "R-RNO-606279", "R-MMU-2467813", "R-HSA-141444", "R-MMU-606279", "R-HSA-9648025", "R-MMU-68877", "R-RNO-5663220", "R-HSA-68877", "R-RNO-205043", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-MMU-9648025", "R-MMU-205043", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR009602": {"description": "CBY1-interacting BAR domain-containing protein/FAM92", "go_ids": [], "go_terms": [], "name": "CBAR/FAM92", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009603": {"description": "Microtubule associated protein Futsch", "go_ids": ["GO:0000226"], "go_terms": ["GO:0000226:microtubule cytoskeleton organization:P"], "name": "MAP_Futsch", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009604": {"description": "LsmAD domain", "go_ids": [], "go_terms": [], "name": "LsmAD_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009605": {"description": "Domain of unknown function DUF1216", "go_ids": [], "go_terms": [], "name": "DUF1216", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009606": {"description": "DESIGUAL/Modifying wall lignin-1/2", "go_ids": [], "go_terms": [], "name": "DEAL/Modifying_wall_lignin1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009607": {"description": "Enhancer of polycomb, C-terminal", "go_ids": [], "go_terms": [], "name": "Enhancer_polycomb_C", "pathway_ids": ["R-HSA-8953750", "R-MMU-8953750", "R-HSA-3214847"], "pathways": ["R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR009608": {"description": "Bradykinin", "go_ids": ["GO:0005179", "GO:0005576", "GO:0035821", "GO:0006952"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C", "GO:0035821:modulation of process of another organism:P", "GO:0006952:defense response:P"], "name": "Bradykinin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009609": {"description": "Phosphonate metabolism PhnG", "go_ids": ["GO:0015716", "GO:0019634"], "go_terms": ["GO:0015716:organic phosphonate transport:P", "GO:0019634:organic phosphonate metabolic process:P"], "name": "Phosphonate_metab_PhnG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009610": {"description": "CbtA toxin of type IV toxin-antitoxin system", "go_ids": [], "go_terms": [], "name": "CbtA_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009612": {"description": "IcmF-related", "go_ids": [], "go_terms": [], "name": "IcmF-rel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009613": {"description": "Lipase maturation factor", "go_ids": ["GO:0051604"], "go_terms": ["GO:0051604:protein maturation:P"], "name": "LMF", "pathway_ids": ["R-MMU-8963889", "R-XTR-8963889", "R-HSA-8963889", "R-RNO-8963889"], "pathways": ["R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-XTR-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes"], "type": "Family"}, "IPR009614": {"description": "Toxin YoeB", "go_ids": ["GO:0004519", "GO:0006401"], "go_terms": ["GO:0004519:endonuclease activity:F", "GO:0006401:RNA catabolic process:P"], "name": "YoeB_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009615": {"description": "Viral desmoplakin, N-terminal", "go_ids": [], "go_terms": [], "name": "Desmo_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009617": {"description": "Seipin", "go_ids": ["GO:0019915"], "go_terms": ["GO:0019915:lipid storage:P"], "name": "Seipin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009618": {"description": "Erp protein", "go_ids": [], "go_terms": [], "name": "Erp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009619": {"description": "Cell division protein CrgA", "go_ids": [], "go_terms": [], "name": "CrgA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009620": {"description": "Uncharacterised protein family UPF0236", "go_ids": [], "go_terms": [], "name": "UPF0236", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009621": {"description": "Uncharacterised protein family UPF0239", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "UPF0239", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009622": {"description": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4", "go_ids": ["GO:0032981"], "go_terms": ["GO:0032981:mitochondrial respiratory chain complex I assembly:P"], "name": "NDUFAF4", "pathway_ids": ["R-DME-6799198", "R-CEL-6799198", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198"], "pathways": ["R-DME-6799198:r:Complex I biogenesis", "R-CEL-6799198:r:Complex I biogenesis", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR009623": {"description": "UPF0242, N-terminal", "go_ids": [], "go_terms": [], "name": "UPF0242_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009624": {"description": "Uncharacterised protein family UPF0253", "go_ids": [], "go_terms": [], "name": "UPF0253", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009625": {"description": "FeGP cofactor biosynthesis protein HcgF", "go_ids": [], "go_terms": [], "name": "HcgF", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR009626": {"description": "Major intrinsically disordered Notch2-binding receptor 1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "MINAR1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009627": {"description": "Uncharacterised protein family UPF0259", "go_ids": [], "go_terms": [], "name": "UPF0259", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009628": {"description": "Bacteriophage tail tape measure, N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_tape_measure_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009629": {"description": "Erythrovirus X", "go_ids": [], "go_terms": [], "name": "Erythrovirus_X", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009630": {"description": "Protein of unknown function DUF1229", "go_ids": [], "go_terms": [], "name": "DUF1229", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009631": {"description": "CGLD27-like", "go_ids": [], "go_terms": [], "name": "CGLD27-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009633": {"description": "Vaccinia virus, B17", "go_ids": [], "go_terms": [], "name": "Vaccinia_virus_B17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009634": {"description": "Rac prophage excisionase XisR", "go_ids": [], "go_terms": [], "name": "XisR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009635": {"description": "Neural proliferation differentiation control-1", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "NPDC1", "pathway_ids": ["R-HSA-198933", "R-MMU-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR009636": {"description": "Capsid assembly scaffolding protein", "go_ids": ["GO:0019069"], "go_terms": ["GO:0019069:viral capsid assembly:P"], "name": "SCAF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009637": {"description": "Transmembrane protein GPR107/GPR108-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "GPR107/GPR108-like", "pathway_ids": ["R-HSA-8980692", "R-MMU-8980692"], "pathways": ["R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Family"}, "IPR009639": {"description": "Peptidase A24A-predicted, C-terminal archaea", "go_ids": [], "go_terms": [], "name": "Pept_A24A_C_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009640": {"description": "Bacteriophage 933W, L0121, tail fibre, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_933W_L0121_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009641": {"description": "Vaccinia virus, A37", "go_ids": [], "go_terms": [], "name": "Vaccinia_virus_A37", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009642": {"description": "Protein of unknown function DUF1236", "go_ids": [], "go_terms": [], "name": "DUF1236", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009643": {"description": "Heat shock factor binding 1", "go_ids": ["GO:0003714"], "go_terms": ["GO:0003714:transcription corepressor activity:F"], "name": "HS1-bd", "pathway_ids": ["R-HSA-3371511", "R-RNO-3371568", "R-MMU-3371568", "R-SPO-3371568", "R-BTA-3371568", "R-SPO-3371571", "R-HSA-3371571", "R-RNO-3371571", "R-BTA-3371571", "R-MMU-3371571", "R-HSA-3371568"], "pathways": ["R-HSA-3371511:r:HSF1 activation", "R-RNO-3371568:r:Attenuation phase", "R-MMU-3371568:r:Attenuation phase", "R-SPO-3371568:r:Attenuation phase", "R-BTA-3371568:r:Attenuation phase", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-3371568:r:Attenuation phase"], "type": "Family"}, "IPR009644": {"description": "FKTN/Mannosyltransferase regulator", "go_ids": [], "go_terms": [], "name": "FKTN/MNN-like", "pathway_ids": ["R-HSA-9939291", "R-MMU-9939291"], "pathways": ["R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1"], "type": "Family"}, "IPR009645": {"description": "2-dehydro-3-deoxy-L-arabinonate dehydratase", "go_ids": [], "go_terms": [], "name": "GguC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009646": {"description": "Root cap", "go_ids": [], "go_terms": [], "name": "Root_cap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009647": {"description": "Penicillin-binding, C-terminal", "go_ids": [], "go_terms": [], "name": "PBP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009648": {"description": "Biotin-dependent malonate decarboxylase, gamma subunit", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "Malonate_gamma", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009649": {"description": "TraU", "go_ids": [], "go_terms": [], "name": "TraU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009650": {"description": "Fijivirus P9-2", "go_ids": [], "go_terms": [], "name": "Fijivirus_P9-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009651": {"description": "Putative methionine gamma-lyase", "go_ids": [], "go_terms": [], "name": "Met_g_lyase_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009652": {"description": "Programmed cell death protein 10", "go_ids": [], "go_terms": [], "name": "PDCD10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009653": {"description": "Protein kish", "go_ids": [], "go_terms": [], "name": "Ksh1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009655": {"description": "Preflagellin peptidase, C-terminal", "go_ids": [], "go_terms": [], "name": "Preflagellin_peptidase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009656": {"description": "PHB de-polymerase, C-terminal", "go_ids": [], "go_terms": [], "name": "PHB_depo_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009657": {"description": "Protein Ac34", "go_ids": [], "go_terms": [], "name": "Protein_Ac34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009658": {"description": "Domain of unknown function DUF1248", "go_ids": [], "go_terms": [], "name": "DUF1248", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009659": {"description": "Protein of unknown function DUF1249", "go_ids": [], "go_terms": [], "name": "DUF1249", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009660": {"description": "Bacteriophage A500, Gp15", "go_ids": [], "go_terms": [], "name": "Phage_A500_Gp15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009661": {"description": "Autographa californica nuclear polyhedrosis virus, Da18", "go_ids": [], "go_terms": [], "name": "AcMNPV_Da18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009662": {"description": "Malonate decarboxylase delta subunit", "go_ids": [], "go_terms": [], "name": "Malonate_deCO2ase_dsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009663": {"description": "Pilin accessory predicted", "go_ids": [], "go_terms": [], "name": "PAP_PilO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009664": {"description": "Pyrimidine/purine nucleoside phosphorylase", "go_ids": [], "go_terms": [], "name": "Ppnp", "pathway_ids": ["PWY-4202", "PWY-5695", "PWY-6611", "PWY-7179", "PWY-6608", "PWY-6609", "PWY-5532", "PWY-6627", "PWY-7181", "PWY-6620", "PWY-8440", "PWY-6644"], "pathways": ["PWY-4202:t:arsenic detoxification (mammals)", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6611:t:adenine and adenosine salvage V", "PWY-7179:t:purine deoxyribonucleosides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6609:t:adenine and adenosine salvage III", "PWY-5532:t:nucleoside and nucleotide degradation (archaea)", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7181:t:pyrimidine deoxyribonucleosides degradation", "PWY-6620:t:guanine and guanosine salvage I", "PWY-8440:t:nucleoside and nucleotide degradation (halobacteria)", "PWY-6644:t:fluoroacetate and fluorothreonine biosynthesis"], "type": "Family"}, "IPR009665": {"description": "Spore protease-like YyaC", "go_ids": [], "go_terms": [], "name": "YyaC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009666": {"description": "Uncharacterised protein family Ycf35", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf35", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009667": {"description": "Protein of unknown function DUF1258", "go_ids": [], "go_terms": [], "name": "DUF1258", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009668": {"description": "RNA polymerase I associated factor, A49-like", "go_ids": ["GO:0003677", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006351:DNA-templated transcription:P"], "name": "RNA_pol-assoc_fac_A49-like", "pathway_ids": ["R-MMU-73762", "R-MMU-5250924", "R-HSA-73772", "R-SPO-73772", "R-SCE-73762", "R-DDI-73772", "R-HSA-73863", "R-HSA-427413", "R-MMU-73863", "R-HSA-5250924", "R-MMU-73772", "R-HSA-73762", "R-SCE-73772", "R-DDI-73762", "R-SPO-73762"], "pathways": ["R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Family"}, "IPR009669": {"description": "Cysteine protease, VirA/EspG", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "Cys_protease_VirA/EspG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009670": {"description": "Cell surface immobilisation antigen SerH", "go_ids": [], "go_terms": [], "name": "SerH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009671": {"description": "Regulator of ribonuclease activity B domain", "go_ids": [], "go_terms": [], "name": "RraB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009672": {"description": "Pkip-1", "go_ids": [], "go_terms": [], "name": "Pkip-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009674": {"description": "DNA-directed RNA polymerase I subunit RPA2, domain 4", "go_ids": ["GO:0003899", "GO:0005634", "GO:0006351"], "go_terms": ["GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0005634:nucleus:C", "GO:0006351:DNA-templated transcription:P"], "name": "Rpa2_dom_4", "pathway_ids": ["R-MMU-5250924", "R-DME-73762", "R-MMU-73762", "R-HSA-73772", "R-DRE-73772", "R-HSA-427413", "R-MMU-73863", "R-DME-73772", "R-HSA-73762", "R-CEL-73772", "R-DRE-5250924", "R-DRE-73762", "R-DRE-73863", "R-HSA-73863", "R-SPO-73772", "R-SCE-73762", "R-DDI-73772", "R-HSA-5250924", "R-MMU-73772", "R-CEL-73762", "R-DDI-73762", "R-SCE-73772", "R-SPO-73762"], "pathways": ["R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DME-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-73762:r:RNA Polymerase I Transcription Initiation", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Domain"}, "IPR009675": {"description": "TPX2", "go_ids": ["GO:0005874", "GO:0005819", "GO:0032147", "GO:0060236"], "go_terms": ["GO:0005874:microtubule:C", "GO:0005819:spindle:C", "GO:0032147:activation of protein kinase activity:P", "GO:0060236:regulation of mitotic spindle organization:P"], "name": "TPX2_fam", "pathway_ids": ["R-MMU-8854518", "R-MMU-6804756", "R-HSA-6804756", "R-XTR-6804756", "R-HSA-8854518", "R-XTR-8854518"], "pathways": ["R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-XTR-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-XTR-8854518:r:AURKA Activation by TPX2"], "type": "Family"}, "IPR009676": {"description": "Protein of unknown function DUF1265", "go_ids": [], "go_terms": [], "name": "DUF1265", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009677": {"description": "Protein of unknown function DUF1266", "go_ids": [], "go_terms": [], "name": "DUF1266", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009678": {"description": "Bacteriophage tail completion protein R", "go_ids": [], "go_terms": [], "name": "Phage_tail_completion_R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009679": {"description": "Bacteriophage 186, CII-like", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Phage_186_CII-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009681": {"description": "Phage tail assembly chaperone protein, Siphoviridae", "go_ids": [], "go_terms": [], "name": "Phage_TAC_Siphoviridae", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009682": {"description": "Protein of unknown function DUF1270", "go_ids": [], "go_terms": [], "name": "DUF1270", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009683": {"description": "Extensin-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Extensin-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009684": {"description": "Latexin", "go_ids": [], "go_terms": [], "name": "Latexin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009685": {"description": "Male enhanced antigen 1", "go_ids": ["GO:0007283"], "go_terms": ["GO:0007283:spermatogenesis:P"], "name": "MEA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009686": {"description": "Senescence/spartin-associated, C-terminal", "go_ids": [], "go_terms": [], "name": "Senescence/spartin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009688": {"description": "Protein FAM210A/B-like domain", "go_ids": [], "go_terms": [], "name": "FAM210A/B-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009689": {"description": "Protein of unknown function DUF1280", "go_ids": [], "go_terms": [], "name": "DUF1280", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009690": {"description": "Bacteriophage T4, Gp30.7", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp30_7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009692": {"description": "P13 protein, Citrus tristeza virus", "go_ids": [], "go_terms": [], "name": "P13_Citrus_tristeza_virus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009693": {"description": "Glucitol operon activator", "go_ids": [], "go_terms": [], "name": "Glucitol_operon_activator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009694": {"description": "Domain of unknown function DUF1281", "go_ids": [], "go_terms": [], "name": "DUF1281", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009695": {"description": "Diacylglycerol glucosyltransferase, N-terminal", "go_ids": ["GO:0009247", "GO:0016758"], "go_terms": ["GO:0009247:glycolipid biosynthetic process:P", "GO:0016758:hexosyltransferase activity:F"], "name": "Diacylglyc_glucosyltr_N", "pathway_ids": ["PWY-7817"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)"], "type": "Domain"}, "IPR009696": {"description": "Putative replisome organiser, C-terminal", "go_ids": [], "go_terms": [], "name": "Rep_Org_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009699": {"description": "Mastadenovirus E4/Orf3", "go_ids": [], "go_terms": [], "name": "Mastadenovirus_E4/Orf3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009700": {"description": "Protein of unknown function DUF1283", "go_ids": [], "go_terms": [], "name": "DUF1283", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009701": {"description": "Special lobe-specific silk SSP160", "go_ids": [], "go_terms": [], "name": "SSP160", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009702": {"description": "Protein of unknown function DUF1284", "go_ids": [], "go_terms": [], "name": "DUF1284", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009703": {"description": "Selenoprotein S", "go_ids": ["GO:0006886", "GO:0005789"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0005789:endoplasmic reticulum membrane:C"], "name": "Selenoprotein_S", "pathway_ids": ["R-HSA-8866654"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Family"}, "IPR009704": {"description": "EURL protein", "go_ids": [], "go_terms": [], "name": "EURL_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009705": {"description": "Protein of unknown function DUF1286", "go_ids": [], "go_terms": [], "name": "DUF1286", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009706": {"description": "Protein of unknown function DUF1287", "go_ids": [], "go_terms": [], "name": "DUF1287", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009707": {"description": "Membrane protein GlpM/YdgC", "go_ids": [], "go_terms": [], "name": "GlpM/YdgC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009708": {"description": "Bacteriophage A118-like, holin/antiholin", "go_ids": [], "go_terms": [], "name": "Phage_A118_holin/antiholin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009709": {"description": "Protein of unknown function DUF1290", "go_ids": [], "go_terms": [], "name": "DUF1290", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009711": {"description": "Uncharacterised protein family UPF0473", "go_ids": [], "go_terms": [], "name": "UPF0473", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009712": {"description": "Vibrio phage Vf33, Vpf117", "go_ids": [], "go_terms": [], "name": "Vibrio_phage_Vf33_Vpf117", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009713": {"description": "Uncharacterised protein family PsiA", "go_ids": [], "go_terms": [], "name": "Uncharacterised_PsiA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009714": {"description": "Resistin-like molecule hormone family", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "RELM", "pathway_ids": ["R-MMU-6798695", "R-BTA-6798695", "R-HSA-9615017", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR009715": {"description": "Regulator of RNA terminal phosphate cyclase", "go_ids": [], "go_terms": [], "name": "RtcR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009716": {"description": "Ferroportin-1", "go_ids": ["GO:0005381", "GO:0016020", "GO:0034755"], "go_terms": ["GO:0005381:iron ion transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0034755:iron ion transmembrane transport:P"], "name": "Ferroportin-1", "pathway_ids": ["R-MMU-917937", "R-HSA-5619060", "R-HSA-5655799", "R-RNO-425410", "R-HSA-917937", "R-RNO-917937", "R-DRE-917937", "R-HSA-425410", "R-MMU-425410", "R-HSA-5619049", "R-CFA-917937", "R-CFA-425410", "R-DRE-425410"], "pathways": ["R-MMU-917937:r:Iron uptake and transport", "R-HSA-5619060:r:Defective CP causes aceruloplasminemia (ACERULOP)", "R-HSA-5655799:r:Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)", "R-RNO-425410:r:Metal ion SLC transporters", "R-HSA-917937:r:Iron uptake and transport", "R-RNO-917937:r:Iron uptake and transport", "R-DRE-917937:r:Iron uptake and transport", "R-HSA-425410:r:Metal ion SLC transporters", "R-MMU-425410:r:Metal ion SLC transporters", "R-HSA-5619049:r:Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)", "R-CFA-917937:r:Iron uptake and transport", "R-CFA-425410:r:Metal ion SLC transporters", "R-DRE-425410:r:Metal ion SLC transporters"], "type": "Family"}, "IPR009717": {"description": "Mo-dependent nitrogenase, C-terminal", "go_ids": [], "go_terms": [], "name": "Mo-dep_Nase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009718": {"description": "Rex DNA-binding, C-terminal domain", "go_ids": ["GO:0045892", "GO:0051775"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0051775:response to redox state:P"], "name": "Rex_DNA-bd_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009719": {"description": "GBF-interacting protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "GIP1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009720": {"description": "IMP biosynthesis enzyme PurP, C-terminal", "go_ids": ["GO:0000287", "GO:0005524", "GO:0006188", "GO:0016879"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0005524:ATP binding:F", "GO:0006188:IMP biosynthetic process:P", "GO:0016879:ligase activity, forming carbon-nitrogen bonds:F"], "name": "IMP_biosynth_PurP_C", "pathway_ids": ["PWY-7234"], "pathways": ["PWY-7234:t:inosine-5'-phosphate biosynthesis III"], "type": "Domain"}, "IPR009721": {"description": "O-acyltransferase WSD1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "O-acyltransferase_WSD1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009722": {"description": "YjiK/CarP", "go_ids": [], "go_terms": [], "name": "YjiK/CarP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009723": {"description": "Pop1, N-terminal", "go_ids": [], "go_terms": [], "name": "Pop1_N", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR009724": {"description": "TMEM70 family", "go_ids": [], "go_terms": [], "name": "TMEM70", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009725": {"description": "Predicted 3-demethylubiquinone-9 3-methyltransferase", "go_ids": [], "go_terms": [], "name": "3_dmu_93_MTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009727": {"description": "NifT/FixU", "go_ids": ["GO:0009399"], "go_terms": ["GO:0009399:nitrogen fixation:P"], "name": "NifT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009728": {"description": "BAALC", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "BAALC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009729": {"description": "Galactose-3-O-sulfotransferase", "go_ids": ["GO:0001733", "GO:0016020", "GO:0009247"], "go_terms": ["GO:0001733:galactosylceramide sulfotransferase activity:F", "GO:0016020:membrane:C", "GO:0009247:glycolipid biosynthetic process:P"], "name": "Gal-3-0_sulfotransfrase", "pathway_ids": ["PWY-8045", "PWY-7831", "PWY-8381", "PWY-6558", "PWY-6546", "PWY-6568", "PWY-6567", "PWY-8358", "R-HSA-9840309", "R-MMU-9840309"], "pathways": ["PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7831:t:ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-6546:t:brassinosteroids inactivation", "PWY-6568:t:dermatan sulfate biosynthesis", "PWY-6567:t:chondroitin sulfate biosynthesis", "PWY-8358:t:curacin A biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis"], "type": "Family"}, "IPR009730": {"description": "Micro-fibrillar-associated protein 1, C-terminal", "go_ids": [], "go_terms": [], "name": "MFAP1_C", "pathway_ids": ["R-HSA-72163", "R-DME-72163", "R-CEL-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR009731": {"description": "Replication P-like", "go_ids": ["GO:0006270"], "go_terms": ["GO:0006270:DNA replication initiation:P"], "name": "P-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009732": {"description": "Protein of unknown function DUF1304", "go_ids": [], "go_terms": [], "name": "DUF1304", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009733": {"description": "Involucrin domain", "go_ids": ["GO:0001533", "GO:0030216"], "go_terms": ["GO:0001533:cornified envelope:C", "GO:0030216:keratinocyte differentiation:P"], "name": "Involucrin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009734": {"description": "Myoviridae, GpU", "go_ids": [], "go_terms": [], "name": "Myoviridae_GpU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009736": {"description": "Protein of unknown function DUF1307", "go_ids": [], "go_terms": [], "name": "DUF1307", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009737": {"description": "Thioredoxin-like ferredoxin", "go_ids": [], "go_terms": [], "name": "Aim32/Apd1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009738": {"description": "BAT2, N-terminal", "go_ids": [], "go_terms": [], "name": "BAT2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009739": {"description": "Lysozyme inhibitor LprI-like, N-terminal", "go_ids": [], "go_terms": [], "name": "LprI-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009741": {"description": "Protein EARLY FLOWERING 4 domain", "go_ids": [], "go_terms": [], "name": "EARLY_FLOWERING_4_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009742": {"description": "Curlin associated", "go_ids": ["GO:0007155", "GO:0009289"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0009289:pilus:C"], "name": "Curlin_rpt", "pathway_ids": ["R-HSA-9638630"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells"], "type": "Repeat"}, "IPR009743": {"description": "Hs1pro-1, C-terminal", "go_ids": [], "go_terms": [], "name": "Hs1pro-1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009744": {"description": "VirC1", "go_ids": [], "go_terms": [], "name": "VirC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009745": {"description": "Cysteine-rich, acidic integral membrane", "go_ids": [], "go_terms": [], "name": "CRAM_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009746": {"description": "Llipid A acylation PagP", "go_ids": [], "go_terms": [], "name": "LipidA_acyl_PagP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009748": {"description": "Orthopoxvirus C10L", "go_ids": [], "go_terms": [], "name": "Orthopox_C10L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009749": {"description": "Protein of unknown function DUF1315", "go_ids": [], "go_terms": [], "name": "DUF1315", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009750": {"description": "Protein of unknown function DUF1317", "go_ids": [], "go_terms": [], "name": "DUF1317", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009751": {"description": "CryBP1", "go_ids": [], "go_terms": [], "name": "CryBP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009752": {"description": "Bacteriophage Mu, Gene product J", "go_ids": [], "go_terms": [], "name": "Phage_Mu_GpJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009753": {"description": "Protein of unknown function DUF1322", "go_ids": [], "go_terms": [], "name": "DUF1322", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009754": {"description": "Orthopoxvirus B11R", "go_ids": [], "go_terms": [], "name": "Orthopox_B11R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009755": {"description": "Regulator of MON1-CCZ1 complex, C-terminal", "go_ids": [], "go_terms": [], "name": "RMC1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009757": {"description": "Circovirus 2, anti-apoptotic ORF4", "go_ids": ["GO:0052150"], "go_terms": ["GO:0052150:symbiont-mediated perturbation of host apoptosis:P"], "name": "Circovirus2_Orf4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009758": {"description": "Protein of unknown function DUF1326", "go_ids": [], "go_terms": [], "name": "DUF1326", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009759": {"description": "Bacteriophage ES18, Gp24-like", "go_ids": [], "go_terms": [], "name": "Phage_ES18_Gp24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009760": {"description": "Protein of unknown function DUF1328", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "DUF1328", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009761": {"description": "Cytoplasmic repetitive antigen-like", "go_ids": [], "go_terms": [], "name": "CRA_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009762": {"description": "Circovirus 2, Orf10", "go_ids": [], "go_terms": [], "name": "Circovirus2_Orf10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009764": {"description": "Ovarian carcinoma immunoreactive antigen domain", "go_ids": [], "go_terms": [], "name": "OCIA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009765": {"description": "Pericardin-like repeat", "go_ids": [], "go_terms": [], "name": "Pericardin-like_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009766": {"description": "White spot syndrome virus (WSSV), Orf116/126, C-terminal", "go_ids": [], "go_terms": [], "name": "WSSV_Orf116/126_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009767": {"description": "DNA helicase, TraI type, C-terminal", "go_ids": ["GO:0003677", "GO:0003678", "GO:0005524", "GO:0016818"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003678:DNA helicase activity:F", "GO:0005524:ATP binding:F", "GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F"], "name": "DNA_helicase_TraI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009768": {"description": "Microtubule-associated protein 70", "go_ids": ["GO:0008017", "GO:0007010"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0007010:cytoskeleton organization:P"], "name": "MAP70", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009769": {"description": "Protein ENHANCED DISEASE RESISTANCE 2, C-terminal", "go_ids": [], "go_terms": [], "name": "EDR2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009770": {"description": "2-oxoadipate dioxygenase/decarboxylase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "HGLS", "pathway_ids": ["PWY-5283"], "pathways": ["PWY-5283:t:L-lysine degradation V"], "type": "Family"}, "IPR009771": {"description": "RIC1, C-terminal alpha solenoid region", "go_ids": [], "go_terms": [], "name": "RIC1_C", "pathway_ids": ["R-CEL-6811440", "R-SCE-6811440", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-CEL-8876198", "R-MMU-8876198", "R-HSA-6811440", "R-DME-8876198", "R-CEL-6811438", "R-HSA-8876198", "R-SPO-6811440", "R-SPO-8876198", "R-SCE-8876198", "R-MMU-6811440"], "pathways": ["R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-6811438:r:Intra-Golgi traffic", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR009772": {"description": "Cell division cycle protein 123", "go_ids": [], "go_terms": [], "name": "CDC123", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009773": {"description": "Lactococcus phage 712, M3", "go_ids": [], "go_terms": [], "name": "Lactococcus_phage_712_M3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009774": {"description": "Streptococcus phage 7201, Orf18", "go_ids": [], "go_terms": [], "name": "Phage_7201_Orf18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009775": {"description": "Envelope small membrane protein", "go_ids": [], "go_terms": [], "name": "GP2b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009776": {"description": "Sporulation stage 0, protein M", "go_ids": [], "go_terms": [], "name": "Spore_0_M", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009777": {"description": "Cell division protein ZapD", "go_ids": [], "go_terms": [], "name": "ZapD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009778": {"description": "Modulator of Rho-dependent transcription termination", "go_ids": [], "go_terms": [], "name": "ROF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009779": {"description": "Translocon-associated protein subunit gamma", "go_ids": ["GO:0016020", "GO:0006614"], "go_terms": ["GO:0016020:membrane:C", "GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P"], "name": "SSR3", "pathway_ids": ["R-HSA-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR009780": {"description": "Protein of unknown function DUF1344", "go_ids": [], "go_terms": [], "name": "DUF1344", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009781": {"description": "Virulence factor BPSS1818", "go_ids": [], "go_terms": [], "name": "BPSS1818", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009782": {"description": "UAP56-interacting factor", "go_ids": ["GO:0006406", "GO:0003729"], "go_terms": ["GO:0006406:mRNA export from nucleus:P", "GO:0003729:mRNA binding:F"], "name": "FYTTD1", "pathway_ids": ["R-RNO-73856", "R-MMU-72187", "R-BTA-73856", "R-BTA-159236", "R-RNO-159236", "R-MMU-73856", "R-HSA-73856", "R-HSA-159236", "R-HSA-72187", "R-MMU-159236"], "pathways": ["R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR009783": {"description": "Protein of unknown function DUF1348", "go_ids": [], "go_terms": [], "name": "DUF1348", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009784": {"description": "Protein of unknown function DUF1349", "go_ids": [], "go_terms": [], "name": "DUF1349", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009785": {"description": "Protein of unknown function DUF1351", "go_ids": [], "go_terms": [], "name": "DUF1351", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009786": {"description": "Spot 14 family", "go_ids": [], "go_terms": [], "name": "Spot_14", "pathway_ids": ["R-HSA-9841922", "R-DRE-200425", "R-HSA-200425", "R-MMU-200425", "R-RNO-200425"], "pathways": ["R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DRE-200425:r:Carnitine shuttle", "R-HSA-200425:r:Carnitine shuttle", "R-MMU-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle"], "type": "Family"}, "IPR009787": {"description": "Protein jagunal", "go_ids": ["GO:0005789", "GO:0007029"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0007029:endoplasmic reticulum organization:P"], "name": "Jagunal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009788": {"description": "GvpD, P-loop domain", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "GvpD_P-loop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009790": {"description": "Transmembrane protein 106", "go_ids": [], "go_terms": [], "name": "TMEM106", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009791": {"description": "Protein of unknown function DUF1357", "go_ids": [], "go_terms": [], "name": "DUF1357", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009792": {"description": "Transmembrane protein 242", "go_ids": [], "go_terms": [], "name": "TMEM242", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009793": {"description": "Protein of unknown function DUF1361", "go_ids": [], "go_terms": [], "name": "DUF1361", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009794": {"description": "Anabaena sensory rhodopsin transducer", "go_ids": [], "go_terms": [], "name": "ASRT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009795": {"description": "Protein of unknown function DUF1363", "go_ids": [], "go_terms": [], "name": "DUF1363", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009796": {"description": "Protein of unknown function DUF1366", "go_ids": [], "go_terms": [], "name": "DUF1366", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009797": {"description": "Protein of unknown function DUF1367", "go_ids": [], "go_terms": [], "name": "DUF1367", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009798": {"description": "Wound-induced protein Wun1-like", "go_ids": [], "go_terms": [], "name": "Wun1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009799": {"description": "EthD domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "EthD_dom", "pathway_ids": ["PWY-5870", "PWY-6309", "PWY-5871", "PWY-7007", "PWY-6322", "PWY-6055", "PWY-8037", "PWY-7769", "PWY-7557", "PWY-6262", "PWY-6627", "PWY-8376", "PWY-5163", "PWY-6340", "PWY-5956", "PWY-5873", "PWY-7154", "PWY-7620", "PWY-3542", "PWY-6633", "PWY-7230", "PWY-6959", "PWY-7931", "PWY-7352", "PWY-5113", "PWY-7372", "PWY-5872", "PWY-7782", "PWY-7690", "PWY-8158", "PWY-5826", "PWY-7419", "PWY-6935", "PWY-8166", "PWY-7742", "PWY-3385", "PWY-7480", "PWY-7741", "PWY-8387", "PWY-8085", "PWY-5706", "PWY-8358"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6055:t:dimethylsulfoniopropanoate biosynthesis II (Spartina)", "PWY-8037:t:saliniketal A biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8376:t:benzene degradation III (anaerobic)", "PWY-5163:t:p-cumate degradation to 2-hydroxypentadienoate", "PWY-6340:t:5,5'-dehydrodivanillate degradation", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-7154:t:ergosterol biosynthesis II", "PWY-7620:t:naphthalene degradation (anaerobic)", "PWY-3542:t:choline biosynthesis II", "PWY-6633:t:caffeine degradation V (bacteria, via trimethylurate)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-6959:t:L-ascorbate degradation V", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-5113:t:UDP-D-apiose biosynthesis (from UDP-D-glucuronate)", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7690:t:holomycin biosynthesis", "PWY-8158:t:ibotenate and muscimol biosynthesis", "PWY-5826:t:hypoglycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6935:t:seleno-amino acid detoxification and volatilization II", "PWY-8166:t:emodin biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-3385:t:choline biosynthesis I", "PWY-7480:t:2,3-dihydroxybenzoate degradation", "PWY-7741:t:phthiocerol biosynthesis", "PWY-8387:t:microcin C biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-5706:t:alliin metabolism", "PWY-8358:t:curacin A biosynthesis"], "type": "Domain"}, "IPR009800": {"description": "Coiled-coil alpha-helical rod protein 1", "go_ids": ["GO:0030154"], "go_terms": ["GO:0030154:cell differentiation:P"], "name": "HCR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009801": {"description": "Transmembrane protein 126", "go_ids": [], "go_terms": [], "name": "TMEM126", "pathway_ids": ["R-DME-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198"], "pathways": ["R-DME-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR009803": {"description": "Protein of unknown function DUF1373", "go_ids": [], "go_terms": [], "name": "DUF1373", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009804": {"description": "Sulfolobus islandicus filamentous virus, Orf14", "go_ids": [], "go_terms": [], "name": "SIFV_Orf14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009805": {"description": "Variable length PCR target", "go_ids": [], "go_terms": [], "name": "Variable_length_PCR_target", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009806": {"description": "Photosystem II PsbW, class 2", "go_ids": ["GO:0009507", "GO:0009523", "GO:0015979"], "go_terms": ["GO:0009507:chloroplast:C", "GO:0009523:photosystem II:C", "GO:0015979:photosynthesis:P"], "name": "PSII_PsbW_class2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009807": {"description": "Phytoreovirus outer capsid P8", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Phytoreo_P8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009808": {"description": "Protein of unknown function, DUF1378", "go_ids": [], "go_terms": [], "name": "DUF1378", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009809": {"description": "Cell division protein ZapC", "go_ids": [], "go_terms": [], "name": "ZapC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009810": {"description": "Late nodulin domain", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Nodulin_late_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009811": {"description": "Protein of unknown function DUF1380", "go_ids": [], "go_terms": [], "name": "DUF1380", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009812": {"description": "Protein of unknown function DUF1381", "go_ids": [], "go_terms": [], "name": "DUF1381", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009813": {"description": "Uncharacterised protein family YebG", "go_ids": [], "go_terms": [], "name": "YebG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009814": {"description": "Bacteriophage lambda, Xis (Q38267)", "go_ids": [], "go_terms": [], "name": "Phage_lambda_Xis_Q38267", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009815": {"description": "Baculovirus protein AC11", "go_ids": [], "go_terms": [], "name": "AcMNPV_AC11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009816": {"description": "SPATS2-like", "go_ids": [], "go_terms": [], "name": "SPATS2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009818": {"description": "PAM2 motif", "go_ids": [], "go_terms": [], "name": "PAM2_motif", "pathway_ids": ["R-HSA-975956", "R-MMU-5689880", "R-HSA-9820865", "R-HSA-975957", "R-MMU-429947", "R-HSA-5689880", "R-HSA-429947", "R-MMU-975957", "R-HSA-9010553", "R-HSA-9820841", "R-MMU-5656169", "R-RNO-5656169", "R-HSA-5656169", "R-HSA-72764", "R-RNO-5689880", "R-MMU-975956", "R-MMU-72764"], "pathways": ["R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-72764:r:Eukaryotic Translation Termination"], "type": "Conserved_site"}, "IPR009819": {"description": "Pes-10", "go_ids": [], "go_terms": [], "name": "Pes-10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009820": {"description": "Protein of unknown function DUF1390", "go_ids": [], "go_terms": [], "name": "DUF1390", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009821": {"description": "Protein of unknown function DUF1391", "go_ids": [], "go_terms": [], "name": "DUF1391", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009822": {"description": "YaeQ", "go_ids": [], "go_terms": [], "name": "YaeQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009823": {"description": "Herpesvirus SORF3", "go_ids": [], "go_terms": [], "name": "Herpes_SORF3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009824": {"description": "Protein of unknown function DUF1392", "go_ids": [], "go_terms": [], "name": "DUF1392", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009825": {"description": "ECF transporter, substrate-specific component-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "ECF_substrate-spec-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009826": {"description": "DNA circulation, N-terminal", "go_ids": [], "go_terms": [], "name": "DNA_circ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009827": {"description": "Dicarboxylate carrier MatC N-terminal", "go_ids": [], "go_terms": [], "name": "MatC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009828": {"description": "CYRIA/CYRIB, Rac1 binding domain", "go_ids": ["GO:0031267"], "go_terms": ["GO:0031267:small GTPase binding:F"], "name": "CYRIA/CYRIB_Rac1-bd", "pathway_ids": ["R-HSA-5663213", "R-HSA-6798695", "R-CEL-6798695", "R-DRE-2029482", "R-MMU-9013408", "R-DRE-9013404", "R-MMU-4420097", "R-MMU-9013404", "R-DDI-114608", "R-DDI-9013149", "R-CEL-9013149", "R-HSA-4420097", "R-HSA-9013423", "R-HSA-114608", "R-BTA-114608", "R-MMU-5663213", "R-DME-2029482", "R-DRE-6798695", "R-DRE-9013149", "R-DDI-9013423", "R-HSA-9013408", "R-CEL-9013423", "R-DME-5663213", "R-DDI-2029482", "R-DDI-6798695", "R-DRE-5663213", "R-HSA-9664422", "R-DME-9013149", "R-DRE-9013408", "R-DME-6798695", "R-DDI-5663213", "R-HSA-2029482", "R-CEL-5663213", "R-MMU-2029482", "R-CEL-2029482", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-MMU-114608", "R-MMU-6798695", "R-DDI-9013404", "R-MMU-9013149", "R-DME-4420097", "R-DME-9013423", "R-DRE-9013423"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-DRE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DDI-114608:r:Platelet degranulation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-6798695:r:Neutrophil degranulation", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DRE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-9013408:r:RHOG GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-114608:r:Platelet degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR009829": {"description": "Spindle and kinetochore-associated protein 1", "go_ids": ["GO:0007059", "GO:0008017", "GO:0051301"], "go_terms": ["GO:0007059:chromosome segregation:P", "GO:0008017:microtubule binding:F", "GO:0051301:cell division:P"], "name": "SKA1", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-RNO-2500257", "R-DRE-2500257", "R-MMU-2467813", "R-HSA-141444", "R-DRE-2467813", "R-DRE-141444", "R-HSA-9648025", "R-RNO-5663220", "R-MMU-68877", "R-HSA-68877", "R-RNO-9648025", "R-RNO-2467813", "R-DRE-5663220", "R-HSA-5663220", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR009830": {"description": "LppX/LprAFG lipoprotein family", "go_ids": [], "go_terms": [], "name": "LppX/LprAFG", "pathway_ids": ["R-HSA-9636383"], "pathways": ["R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion"], "type": "Family"}, "IPR009832": {"description": "Protein of unknown function DUF1397", "go_ids": [], "go_terms": [], "name": "DUF1397", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009833": {"description": "Uncharacterised protein DUF1398", "go_ids": [], "go_terms": [], "name": "DUF1398", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009834": {"description": "Ureide permease", "go_ids": ["GO:0016020", "GO:0071705"], "go_terms": ["GO:0016020:membrane:C", "GO:0071705:nitrogen compound transport:P"], "name": "Ureide_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009835": {"description": "Sortase B family", "go_ids": [], "go_terms": [], "name": "SrtB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009836": {"description": "GRDP1/2 domain", "go_ids": [], "go_terms": [], "name": "GRDP1/2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009837": {"description": "Matrix extracellular phosphoglycoprotein", "go_ids": ["GO:0031214"], "go_terms": ["GO:0031214:biomineral tissue development:P"], "name": "MEPE", "pathway_ids": ["R-RNO-381426", "R-HSA-381426", "R-HSA-8957275", "R-RNO-8957275", "R-MMU-8957275", "R-MMU-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR009838": {"description": "Type IV conjugative transfer system, protein TraL", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "T4SS_TraL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009839": {"description": "SseB, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SseB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009841": {"description": "VirC2", "go_ids": [], "go_terms": [], "name": "VirC2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009842": {"description": "Protein of unknown function DUF1402", "go_ids": [], "go_terms": [], "name": "DUF1402", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009843": {"description": "Protein of unknown function DUF1403", "go_ids": [], "go_terms": [], "name": "DUF1403", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009844": {"description": "Protein of unknown function DUF1404", "go_ids": [], "go_terms": [], "name": "DUF1404", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009845": {"description": "Protein of unknown function DUF1405", "go_ids": [], "go_terms": [], "name": "DUF1405", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009846": {"description": "Splicing factor 3B subunit 5/RDS3 complex subunit 10", "go_ids": [], "go_terms": [], "name": "SF3b5/RDS3-10", "pathway_ids": ["R-DME-9770562", "R-SPO-9770562", "R-HSA-72163", "R-DME-72165", "R-BTA-72165", "R-MMU-72165", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-BTA-9770562", "R-HSA-72165", "R-DME-72163", "R-DDI-9770562", "R-HSA-9918481", "R-BTA-72163"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR009847": {"description": "SNURF family", "go_ids": [], "go_terms": [], "name": "SNURF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009848": {"description": "Protein of unknown function DUF1408", "go_ids": [], "go_terms": [], "name": "DUF1408", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009849": {"description": "Domain of unknown function DUF1410", "go_ids": [], "go_terms": [], "name": "DUF1410", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009850": {"description": "Domain of unknown function DUF1411", "go_ids": [], "go_terms": [], "name": "DUF1411", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009851": {"description": "Modifier of rudimentary, Modr", "go_ids": [], "go_terms": [], "name": "Mod_r", "pathway_ids": ["R-HSA-9610379", "R-HSA-917729", "R-MMU-917729", "R-HSA-174490", "R-HSA-9615710", "R-DDI-917729", "R-HSA-162588"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-9615710:r:Late endosomal microautophagy", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion"], "type": "Domain"}, "IPR009852": {"description": "Centromere protein J, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CENPJ_C_dom", "pathway_ids": ["R-HSA-380320", "R-HSA-6804115", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-6804115", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR009853": {"description": "Protein of unknown function DUF1412", "go_ids": [], "go_terms": [], "name": "DUF1412", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009854": {"description": "Orthoreovirus membrane fusion p10", "go_ids": [], "go_terms": [], "name": "Orthoreo_P10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009855": {"description": "Baculovirus late expression factor 10", "go_ids": [], "go_terms": [], "name": "Baculo_LEF-10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009856": {"description": "Light regulated Lir1", "go_ids": ["GO:0009507"], "go_terms": ["GO:0009507:chloroplast:C"], "name": "Lir1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009857": {"description": "Uncharacterised protein family UPF0352", "go_ids": [], "go_terms": [], "name": "UPF0352", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009858": {"description": "Protein of unknown function DUF1415", "go_ids": [], "go_terms": [], "name": "DUF1415", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009859": {"description": "Protein of unknown function, Gam-like", "go_ids": [], "go_terms": [], "name": "Gam-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009860": {"description": "Hyaluronidase, bacterial", "go_ids": ["GO:0004415", "GO:0045227"], "go_terms": ["GO:0004415:hyalurononglucosaminidase activity:F", "GO:0045227:capsule polysaccharide biosynthetic process:P"], "name": "Hyaluronidase_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009861": {"description": "Hematopoietic cell signal transducer", "go_ids": ["GO:0005102", "GO:0043548", "GO:0050776", "GO:0016020", "GO:0051897"], "go_terms": ["GO:0005102:signaling receptor binding:F", "GO:0043548:phosphatidylinositol 3-kinase binding:F", "GO:0050776:regulation of immune response:P", "GO:0016020:membrane:C", "GO:0051897:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction:P"], "name": "HCST", "pathway_ids": ["R-HSA-198933", "R-MMU-198933", "R-BTA-198933", "R-SSC-198933", "R-RNO-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-SSC-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR009862": {"description": "Protein of unknown function DUF1419", "go_ids": [], "go_terms": [], "name": "DUF1419", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009863": {"description": "Type III secretion protein, LcrG", "go_ids": [], "go_terms": [], "name": "T3SS_LcrG_PcrG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009864": {"description": "Rhoptry-associated protein 1, plasmodium", "go_ids": [], "go_terms": [], "name": "RAP1_Plasmodium", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009865": {"description": "Proacrosin binding sp32", "go_ids": [], "go_terms": [], "name": "Proacrosin-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009866": {"description": "NADH:ubiquinone oxidoreductase, subunit NDUFB4", "go_ids": ["GO:0005739"], "go_terms": ["GO:0005739:mitochondrion:C"], "name": "NADH_UbQ_OxRdtase_NDUFB4_su", "pathway_ids": ["R-MMU-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105"], "pathways": ["R-MMU-6799198:r:Complex I biogenesis", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR009867": {"description": "Protein of unknown function DUF1422", "go_ids": [], "go_terms": [], "name": "DUF1422", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009868": {"description": "VirE2", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "VirE2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009869": {"description": "Nematode resistance protein-like HSPRO1, N-terminal", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "HSPRO1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009870": {"description": "Putative replication protein DUF1424", "go_ids": [], "go_terms": [], "name": "DUF1424", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009871": {"description": "Movement and RNA silencing protein", "go_ids": [], "go_terms": [], "name": "MP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009872": {"description": "Protein of unknown function DUF1427", "go_ids": [], "go_terms": [], "name": "DUF1427", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009873": {"description": "Phytoreovirus S7", "go_ids": [], "go_terms": [], "name": "Phytoreo_S7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009874": {"description": "Protein of unknown function DUF1428", "go_ids": [], "go_terms": [], "name": "DUF1428", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009875": {"description": "PilZ domain", "go_ids": ["GO:0035438"], "go_terms": ["GO:0035438:cyclic-di-GMP binding:F"], "name": "PilZ_domain", "pathway_ids": ["R-HSA-9931953"], "pathways": ["R-HSA-9931953:r:Biofilm formation"], "type": "Domain"}, "IPR009876": {"description": "Outer membrane adhesin OpcA", "go_ids": [], "go_terms": [], "name": "OM_adhesin_OpcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009878": {"description": "Phlebovirus glycoprotein G2, fusion domain", "go_ids": [], "go_terms": [], "name": "Phlebovirus_G2_fusion", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009879": {"description": "Phlebovirus nonstructural NS-M", "go_ids": [], "go_terms": [], "name": "Phlebovirus_NSM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009880": {"description": "Glyoxal oxidase, N-terminal", "go_ids": [], "go_terms": [], "name": "Glyoxal_oxidase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009881": {"description": "Protein of unknown function DUF1433", "go_ids": [], "go_terms": [], "name": "DUF1433", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009882": {"description": "Gypsy", "go_ids": [], "go_terms": [], "name": "Gypsy", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009883": {"description": "Inner membrane protein YgfX", "go_ids": [], "go_terms": [], "name": "YgfX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009885": {"description": "Protein of unknown function DUF1435", "go_ids": [], "go_terms": [], "name": "DUF1435", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009887": {"description": "Progressive ankylosis", "go_ids": ["GO:0016020", "GO:0005315", "GO:0035435"], "go_terms": ["GO:0016020:membrane:C", "GO:0005315:phosphate transmembrane transporter activity:F", "GO:0035435:phosphate ion transmembrane transport:P"], "name": "ANKH", "pathway_ids": ["R-HSA-5223345", "R-RNO-5223345", "R-MMU-5223345", "R-DRE-5223345"], "pathways": ["R-HSA-5223345:r:Miscellaneous transport and binding events", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-DRE-5223345:r:Miscellaneous transport and binding events"], "type": "Family"}, "IPR009888": {"description": "Immunity protein CdiI, Proteobacteria type", "go_ids": [], "go_terms": [], "name": "CdiI_Proteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009889": {"description": "Dentin matrix 1", "go_ids": ["GO:0001503", "GO:0030198"], "go_terms": ["GO:0001503:ossification:P", "GO:0030198:extracellular matrix organization:P"], "name": "DMP1", "pathway_ids": ["R-RNO-381426", "R-MMU-3000178", "R-RNO-8957275", "R-MMU-381426", "R-HSA-3000178", "R-HSA-8957275", "R-RNO-3000178", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR009891": {"description": "Tapetum specific TAP35/TAP44", "go_ids": [], "go_terms": [], "name": "TAP35_44", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009893": {"description": "Nucleopolyhedrovirus capsid P80/P87", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Nucleo_P80/P87", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009894": {"description": "Exported", "go_ids": [], "go_terms": [], "name": "EppA_BapA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009895": {"description": "Protein of unknown function DUF1438", "go_ids": [], "go_terms": [], "name": "DUF1438", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009896": {"description": "Cytadhesin P30/P32", "go_ids": ["GO:0044650", "GO:0016020"], "go_terms": ["GO:0044650:adhesion of symbiont to host cell:P", "GO:0016020:membrane:C"], "name": "Cytadhesin_P30/P32", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009897": {"description": "Orthoreovirus P17", "go_ids": [], "go_terms": [], "name": "Orthoreo_P17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009898": {"description": "Protein of unknown function DUF1440", "go_ids": [], "go_terms": [], "name": "DUF1440", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009899": {"description": "Antirestriction", "go_ids": [], "go_terms": [], "name": "ArdA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009900": {"description": "Apopolysialoglycoprotein", "go_ids": [], "go_terms": [], "name": "PSGP", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR009901": {"description": "Protein of unknown function DUF1441", "go_ids": [], "go_terms": [], "name": "DUF1441", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009902": {"description": "Protein of unknown function DUF1442", "go_ids": [], "go_terms": [], "name": "DUF1442", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009903": {"description": "Per os infectivity factor AC110", "go_ids": [], "go_terms": [], "name": "AcMNPV_AC110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009905": {"description": "2-vinyl bacteriochlorophyllide hydratase", "go_ids": ["GO:0016836", "GO:0019685", "GO:0030494"], "go_terms": ["GO:0016836:hydro-lyase activity:F", "GO:0019685:photosynthesis, dark reaction:P", "GO:0030494:bacteriochlorophyll biosynthetic process:P"], "name": "BCHF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009906": {"description": "D-glutamate cyclase-like domain", "go_ids": [], "go_terms": [], "name": "D-Glu_cyclase", "pathway_ids": ["PWY-7045", "PWY-8319", "PWY-7811", "PWY-6322", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7814", "PWY-6627", "PWY-6946", "PWY-6945", "PWY-7188", "PWY-5780", "PWY-7897", "PWY-7275", "PWY-5367", "PWY-8152", "PWY-8029", "PWY-6948", "PWY-8134", "PWY-7610", "PWY-7695", "PWY-7354", "PWY-8335", "PWY-6944", "PWY-7547", "PWY-8012", "PWY-2229", "PWY-5793", "PWY-7352", "PWY-2467", "PWY-8044", "PWY-6602", "PWY-6679", "PWY-7757", "PWY-7510", "PWY-5979", "PWY-721", "PWY-5644", "PWY-5408", "PWY-7821", "PWY-7189", "PWY-5410", "PWY-7613", "PWYG-321", "PWY-5061", "PWY-6721", "PWY-6672", "PWY-5409", "PWY-6749", "PWY-7428", "PWY-8151"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-8319:t:NiFe(CO)(CN)2 cofactor biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7188:t:orientin and isoorientin biosynthesis I", "PWY-5780:t:hypericin biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-7275:t:L-homophenylalanine biosynthesis", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-8134:t:bile acid 7beta-dehydroxylation", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-8335:t:plasmalogen biosynthesis II (anaerobic)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7547:t:prodigiosin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-2229:t:superpathway of pterocarpan biosynthesis (via formononetin)", "PWY-5793:t:maysin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-2467:t:(+)-pisatin biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6602:t:naringenin C-glucosylation", "PWY-6679:t:jadomycin biosynthesis", "PWY-7757:t:bisphenol A degradation", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-721:t:3-methylquinoline degradation", "PWY-5644:t:4-nitrotoluene degradation II", "PWY-5408:t:9-lipoxygenase and 9-hydroperoxide lyase pathway", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7189:t:pinocembrin C-glucosylation", "PWY-5410:t:traumatin and (Z)-3-hexen-1-yl acetate biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5061:t:6,7,4'-trihydroxyisoflavone biosynthesis", "PWY-6721:t:sangivamycin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-5409:t:divinyl ether biosynthesis II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7428:t:2-chloroacrylate degradation II", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)"], "type": "Domain"}, "IPR009907": {"description": "RNA polymerase epsilon subunit", "go_ids": [], "go_terms": [], "name": "RpoY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009908": {"description": "Methylamine utilisation protein, MauE", "go_ids": ["GO:0016020", "GO:0030416"], "go_terms": ["GO:0016020:membrane:C", "GO:0030416:methylamine metabolic process:P"], "name": "Methylamine_util_MauE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009909": {"description": "Nmi/IFP 35 domain", "go_ids": [], "go_terms": [], "name": "Nmi/IFP35_dom", "pathway_ids": ["R-HSA-909733", "R-HSA-9692916"], "pathways": ["R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Domain"}, "IPR009910": {"description": "Protein of unknown function DUF1450", "go_ids": [], "go_terms": [], "name": "DUF1450", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009911": {"description": "Fibroin P25", "go_ids": ["GO:0005198", "GO:0005576"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0005576:extracellular region:C"], "name": "Fibroin_P25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009912": {"description": "Zinc-ribbon containing domain", "go_ids": [], "go_terms": [], "name": "DUF1451", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009913": {"description": "TraP", "go_ids": [], "go_terms": [], "name": "TraP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009914": {"description": "Dolichol phosphate-mannose biosynthesis regulatory", "go_ids": ["GO:0030234", "GO:0005789", "GO:0180047"], "go_terms": ["GO:0030234:enzyme regulator activity:F", "GO:0005789:endoplasmic reticulum membrane:C", "GO:0180047:dolichol phosphate mannose biosynthetic process:P"], "name": "DPM2", "pathway_ids": ["R-MMU-162699", "R-SPO-162710", "R-HSA-162699", "R-DDI-162699", "R-HSA-162710", "R-RNO-162699", "R-HSA-4719360", "R-RNO-162710", "R-HSA-9918432", "R-SPO-162699", "R-MMU-162710", "R-HSA-4717374", "R-HSA-4719377", "R-DDI-162710"], "pathways": ["R-MMU-162699:r:Synthesis of dolichyl-phosphate mannose", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162699:r:Synthesis of dolichyl-phosphate mannose", "R-DDI-162699:r:Synthesis of dolichyl-phosphate mannose", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-162699:r:Synthesis of dolichyl-phosphate mannose", "R-HSA-4719360:r:Defective DPM3 causes DPM3-CDG", "R-RNO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-9918432:r:Maturation of DENV proteins", "R-SPO-162699:r:Synthesis of dolichyl-phosphate mannose", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-4717374:r:Defective DPM1 causes DPM1-CDG", "R-HSA-4719377:r:Defective DPM2 causes DPM2-CDG", "R-DDI-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR009915": {"description": "NnrU domain", "go_ids": [], "go_terms": [], "name": "NnrU_dom", "pathway_ids": ["PWY-7793"], "pathways": ["PWY-7793:t:dimethyl sulfide biosynthesis from methionine"], "type": "Domain"}, "IPR009917": {"description": "SRA1/Sec31", "go_ids": [], "go_terms": [], "name": "SRA1/Sec31", "pathway_ids": ["R-SCE-204005", "R-SPO-204005"], "pathways": ["R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR009918": {"description": "Protein of unknown function DUF1454", "go_ids": [], "go_terms": [], "name": "DUF1454", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009919": {"description": "Protein of unknown function DUF1455", "go_ids": [], "go_terms": [], "name": "DUF1455", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009920": {"description": "Heptaprenyl diphosphate synthase subunit 1", "go_ids": ["GO:0009234"], "go_terms": ["GO:0009234:menaquinone biosynthetic process:P"], "name": "HEPPP_synth_su1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009921": {"description": "YehS-like", "go_ids": [], "go_terms": [], "name": "YehS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009922": {"description": "Protein of unknown function DUF1457", "go_ids": [], "go_terms": [], "name": "DUF1457", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009923": {"description": "Dodecin", "go_ids": [], "go_terms": [], "name": "Dodecin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009924": {"description": "Protein of unknown function DUF1459", "go_ids": [], "go_terms": [], "name": "DUF1459", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009925": {"description": "Protein of unknown function DUF1463", "go_ids": [], "go_terms": [], "name": "DUF1463", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009926": {"description": "Type III secretion system flagellar brake protein YcgR, PilZN domain", "go_ids": [], "go_terms": [], "name": "T3SS_YcgR_PilZN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009927": {"description": "Protein of unknown function DUF1464", "go_ids": [], "go_terms": [], "name": "DUF1464", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009928": {"description": "Primosomal DnaI, N-terminal", "go_ids": [], "go_terms": [], "name": "DnaI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009929": {"description": "Type III secretion sytem,YscO", "go_ids": [], "go_terms": [], "name": "T3SS_YscO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009930": {"description": "Structural protein Vp10, Seadornavirus", "go_ids": [], "go_terms": [], "name": "Seadorna_Vp10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009931": {"description": "Curtovirus V2", "go_ids": [], "go_terms": [], "name": "Curto_V2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009932": {"description": "RCS1", "go_ids": [], "go_terms": [], "name": "RCS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009933": {"description": "T-DNA border endonuclease VirD1", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "VirD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009935": {"description": "Protein of unknown function DUF1467", "go_ids": [], "go_terms": [], "name": "DUF1467", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009936": {"description": "Domain of unknown function DUF1468", "go_ids": [], "go_terms": [], "name": "DUF1468", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009937": {"description": "Putative Actinobacterial Holin-X, holin superfamily III", "go_ids": [], "go_terms": [], "name": "Phage_holin_3_6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009938": {"description": "Nmi/IFP 35 domain, N-terminal", "go_ids": [], "go_terms": [], "name": "Nmi/IFP35_N", "pathway_ids": ["R-HSA-909733", "R-HSA-9692916"], "pathways": ["R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Domain"}, "IPR009939": {"description": "Fungal chitosanase", "go_ids": ["GO:0016977"], "go_terms": ["GO:0016977:chitosanase activity:F"], "name": "Chitosanase_fungal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009941": {"description": "Protein of unknown function DUF1473", "go_ids": [], "go_terms": [], "name": "DUF1473", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009942": {"description": "TscT toxin domain", "go_ids": [], "go_terms": [], "name": "DUF1474", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009943": {"description": "Protein of unknown function DUF1475", "go_ids": [], "go_terms": [], "name": "DUF1475", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009944": {"description": "Amastin surface glycoprotein", "go_ids": [], "go_terms": [], "name": "Amastin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009945": {"description": "ATPase inhibitor subunit zeta", "go_ids": [], "go_terms": [], "name": "ATPase_inh_sub_z", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009946": {"description": "Autographa californica nuclear polyhedrosis virus, Orf4", "go_ids": [], "go_terms": [], "name": "AcMNPV_Orf4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009947": {"description": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7", "go_ids": ["GO:0005743", "GO:0042773"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C", "GO:0042773:ATP synthesis coupled electron transport:P"], "name": "NDUA7", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR009948": {"description": "Syd", "go_ids": ["GO:0009898"], "go_terms": ["GO:0009898:cytoplasmic side of plasma membrane:C"], "name": "Syd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009949": {"description": "Sapovirus VP3", "go_ids": [], "go_terms": [], "name": "Sapovirus_VP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009950": {"description": "Protein of unknown function DUF1480", "go_ids": [], "go_terms": [], "name": "DUF1480", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009951": {"description": "Host-nuclease inhibitor protein Gam", "go_ids": ["GO:0003690", "GO:0042262"], "go_terms": ["GO:0003690:double-stranded DNA binding:F", "GO:0042262:DNA protection:P"], "name": "Host-nuc_inhib_Gam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009952": {"description": "Uroplakin-2", "go_ids": [], "go_terms": [], "name": "Uroplakin-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009953": {"description": "Dinitrogenase reductase ADP-ribosyltransferase", "go_ids": ["GO:0030701", "GO:0009399"], "go_terms": ["GO:0030701:NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity:F", "GO:0009399:nitrogen fixation:P"], "name": "DRA_trans", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009954": {"description": "Protein of unknown function DUF1482", "go_ids": [], "go_terms": [], "name": "DUF1482", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009955": {"description": "Liver-expressed antimicrobial peptide 2", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense response to bacterium:P"], "name": "LEAP-2", "pathway_ids": ["R-MMU-6803157", "R-HSA-6803157", "R-BTA-6803157"], "pathways": ["R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-BTA-6803157:r:Antimicrobial peptides"], "type": "Family"}, "IPR009956": {"description": "Post-segregation antitoxin CcdA", "go_ids": [], "go_terms": [], "name": "Post-segregation_anti-tox_CcdA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009957": {"description": "Protein of unknown function DUF1484", "go_ids": [], "go_terms": [], "name": "DUF1484", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009958": {"description": "Conotoxin, alpha-type", "go_ids": ["GO:0005576", "GO:0030550"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0030550:acetylcholine receptor inhibitor activity:F"], "name": "Conotoxin_a-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009959": {"description": "Polyketide cyclase SnoaL-like", "go_ids": ["GO:0030638"], "go_terms": ["GO:0030638:polyketide metabolic process:P"], "name": "Cyclase_SnoaL-like", "pathway_ids": ["PWY-7354", "PWY-7352"], "pathways": ["PWY-7354:t:aclacinomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis"], "type": "Family"}, "IPR009960": {"description": "Fungal fruit body lectin", "go_ids": [], "go_terms": [], "name": "Fruit_body_lectin_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009961": {"description": "Protein of unknown function DUF1487", "go_ids": [], "go_terms": [], "name": "DUF1487", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009962": {"description": "Protein of unknown function DUF1488", "go_ids": [], "go_terms": [], "name": "DUF1488", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009963": {"description": "Protein of unknown function DUF1490", "go_ids": [], "go_terms": [], "name": "DUF1490", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009964": {"description": "Protein of unknown function DUF1491", "go_ids": [], "go_terms": [], "name": "DUF1491", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009966": {"description": "Prosystemin/Systemin", "go_ids": [], "go_terms": [], "name": "Prosystemin/Systemin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009967": {"description": "Flagellum biosynthesis repressor FlbT", "go_ids": ["GO:0006402", "GO:0048027", "GO:1902209"], "go_terms": ["GO:0006402:mRNA catabolic process:P", "GO:0048027:mRNA 5'-UTR binding:F", "GO:1902209:negative regulation of bacterial-type flagellum assembly:P"], "name": "Flagellum_FlbT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009968": {"description": "Protein of unknown function DUF1494", "go_ids": [], "go_terms": [], "name": "DUF1494", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009969": {"description": "Pneumovirus M2-2", "go_ids": [], "go_terms": [], "name": "Pneumo_M2-2", "pathway_ids": ["R-HSA-9828721", "R-HSA-9828642", "R-HSA-9834752"], "pathways": ["R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9828642:r:Respiratory syncytial virus genome transcription", "R-HSA-9834752:r:Respiratory syncytial virus genome replication"], "type": "Family"}, "IPR009970": {"description": "Histone H1-like nucleoprotein HC2", "go_ids": ["GO:0003677", "GO:0030261", "GO:0030527"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0030261:chromosome condensation:P", "GO:0030527:structural constituent of chromatin:F"], "name": "HC2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009971": {"description": "Protein of unknown function DUF1496", "go_ids": [], "go_terms": [], "name": "DUF1496", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009972": {"description": "Protein of unknown function DUF1497", "go_ids": [], "go_terms": [], "name": "DUF1497", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009973": {"description": "Seadornavirus VP7", "go_ids": [], "go_terms": [], "name": "Seadorna_VP7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009974": {"description": "Vaccinia virus, B6", "go_ids": [], "go_terms": [], "name": "Vaccinia_virus_B6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009975": {"description": "Mycoplasma P30", "go_ids": [], "go_terms": [], "name": "P30", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009976": {"description": "Exocyst complex component Sec10-like", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "Sec10-like", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-HSA-1445148", "R-MMU-264876", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-264876:r:Insulin processing", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Family"}, "IPR009977": {"description": "Mig-14", "go_ids": [], "go_terms": [], "name": "Mig-14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009978": {"description": "Putative Na+/H+ antiporter", "go_ids": [], "go_terms": [], "name": "Na_H_antiport_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009979": {"description": "Bovine Lentivirus VIF", "go_ids": [], "go_terms": [], "name": "Lenti_VIF_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009980": {"description": "Human herpesvirus U26", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Herpes_U26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009981": {"description": "Protein of unknown function DUF1505", "go_ids": [], "go_terms": [], "name": "DUF1505", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009982": {"description": "Seadornavirus VP6", "go_ids": [], "go_terms": [], "name": "Seadorna_VP6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009983": {"description": "Uncharacterised protein family UPF0358", "go_ids": [], "go_terms": [], "name": "UPF0358", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009985": {"description": "Crinivirus P26", "go_ids": [], "go_terms": [], "name": "Crinivirus_P26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009986": {"description": "Sigma factor-binding transcriptional regulator Crl", "go_ids": ["GO:0045893"], "go_terms": ["GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "Tscrpt_reg_Crl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009987": {"description": "PilM, inner membrane", "go_ids": [], "go_terms": [], "name": "IM_PilM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009988": {"description": "Regulatory protein RagB, C-terminal", "go_ids": [], "go_terms": [], "name": "RagB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009989": {"description": "TrbM", "go_ids": [], "go_terms": [], "name": "TrbM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009990": {"description": "Pardaxin", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Pardaxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009991": {"description": "Dynactin subunit 3", "go_ids": ["GO:0061640", "GO:0005869"], "go_terms": ["GO:0061640:cytoskeleton-dependent cytokinesis:P", "GO:0005869:dynactin complex:C"], "name": "DCTN3", "pathway_ids": 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required for interphase microtubule organization from the centrosome", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-SSC-2132295:r:MHC class II antigen presentation", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-2132295:r:MHC class II antigen presentation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR009992": {"description": "Acyltransferase Tri3/Sat12/Sat16/Mac1", "go_ids": ["GO:0043386", "GO:0016407"], "go_terms": ["GO:0043386:mycotoxin biosynthetic process:P", "GO:0016407:acetyltransferase activity:F"], "name": "Tri3/Sat12/Sat16/Mac1", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis"], "type": "Family"}, "IPR009993": {"description": "TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase", "go_ids": ["GO:0008417", "GO:0009246"], "go_terms": ["GO:0008417:fucosyltransferase activity:F", "GO:0009246:enterobacterial common antigen biosynthetic process:P"], "name": "WecF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009994": {"description": "Phloem filament PP1", "go_ids": [], "go_terms": [], "name": "PP1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009995": {"description": "Protein of unknown function DUF1512", "go_ids": [], "go_terms": [], "name": "DUF1512", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009996": {"description": "Regulatory protein YycH", "go_ids": [], "go_terms": [], "name": "YycH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR009997": {"description": "Movement protein R3", "go_ids": [], "go_terms": [], "name": "MP_R3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009998": {"description": "YfaZ", "go_ids": [], "go_terms": [], "name": "YfaZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR009999": {"description": "Protein of unknown function DUF1514", "go_ids": [], "go_terms": [], "name": "DUF1514", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010000": {"description": "Caerin 1", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Caerin_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010001": {"description": "SigmaK-factor processing regulatory BofA", "go_ids": [], "go_terms": [], "name": "BofA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010002": {"description": "Poneritoxin", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Poneritoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010003": {"description": "HARP domain", "go_ids": [], "go_terms": [], "name": "HARP_dom", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR010004": {"description": "Uncharacterised protein family Ycf66", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf66", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010005": {"description": "Formate hydrogenlyase maturation HycH", "go_ids": [], "go_terms": [], "name": "Formate_DH_maturation_HycH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010006": {"description": "Bacteriophage P4, Psu, polarity suppression protein", "go_ids": [], "go_terms": [], "name": "Phage_P4_Psu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010007": {"description": "SPAN-X family", "go_ids": [], "go_terms": [], "name": "SPAN-X_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010008": {"description": "Vibrio phage CTX, RstB", "go_ids": [], "go_terms": [], "name": "Vibrio_Phage_CTX_RstB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010009": {"description": "Apolipophorin-III", "go_ids": ["GO:0005576", "GO:0006869", "GO:0008289"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006869:lipid transport:P", "GO:0008289:lipid binding:F"], "name": "ApoLp-III", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010010": {"description": "Photosystem I PsaM, reaction centre", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "PSI_PsaM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010011": {"description": "Nuclear receptor coactivator, DUF1518", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "NCO_DUF1518", "pathway_ids": ["R-HSA-1989781", "R-RNO-193807", "R-DRE-211976", "R-DRE-193807", "R-HSA-2151201", "R-DRE-192105", "R-DRE-193368", "R-HSA-193368", "R-RNO-5687128", "R-DRE-400206", "R-RNO-9018519", "R-HSA-1368108", "R-HSA-5625886", "R-HSA-9841922", "R-RNO-192105", "R-HSA-9844594", "R-RNO-159418", "R-RNO-5625886", "R-HSA-9933387", "R-HSA-9707564", "R-MMU-5625886", "R-MMU-400206", "R-DRE-3214847", "R-HSA-9029569", "R-MMU-9029569", "R-HSA-9018519", "R-HSA-9931509", "R-HSA-2426168", "R-MMU-3214847", "R-HSA-9623433", "R-HSA-5617472", "R-RNO-400206", "R-MMU-193368", "R-MMU-3899300", "R-MMU-9623433", "R-DRE-5625886", "R-MMU-192105", "R-HSA-381340", "R-HSA-9707616", "R-HSA-192105", "R-RNO-9707564", "R-HSA-193807", "R-MMU-9018519", "R-DRE-159418", "R-RNO-3214847", "R-HSA-5687128", "R-MMU-211976", "R-RNO-211976", "R-RNO-193368", "R-HSA-400206", "R-RNO-9841922", "R-HSA-3214847", "R-HSA-159418", "R-DRE-9707564", "R-MMU-5687128", "R-HSA-3899300", "R-HSA-211976", "R-MMU-159418", "R-MMU-9707564", "R-MMU-193807"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DRE-211976:r:Endogenous sterols", "R-DRE-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DRE-192105:r:Synthesis of bile acids and bile salts", "R-DRE-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 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(androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DRE-3214847:r:HATs acetylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-DRE-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DRE-159418:r:Recycling of bile acids and salts", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-211976:r:Endogenous sterols", "R-RNO-211976:r:Endogenous sterols", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-9841922:r:MLL4 and 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"R-SCE-5358493", "R-MMU-5358493", "R-DDI-5358493", "R-HSA-5358493", "R-DRE-5358493"], "pathways": ["R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Family"}, "IPR010016": {"description": "5-oxoprolinase subunit B", "go_ids": [], "go_terms": [], "name": "PxpB", "pathway_ids": ["PWY-4041", "PWY-7942"], "pathways": ["PWY-4041:t:gamma-glutamyl cycle", "PWY-7942:t:5-oxo-L-proline metabolism"], "type": "Family"}, "IPR010017": {"description": "tRNA U34 carboxymethyltransferase", "go_ids": ["GO:0002098", "GO:0016765"], "go_terms": ["GO:0002098:tRNA wobble uridine modification:P", "GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "CmoB", 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"Phosphatidylglycerophosphate phosphatase", "go_ids": ["GO:0008962"], "go_terms": ["GO:0008962:phosphatidylglycerophosphatase activity:F"], "name": "PGPP1/Gep4", "pathway_ids": ["PWY-5668", "PWY-7817", "PWY-5269"], "pathways": ["PWY-5668:t:cardiolipin biosynthesis I", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-5269:t:cardiolipin biosynthesis II"], "type": "Family"}, "IPR010022": {"description": "Protein of unknown function XkdX", "go_ids": [], "go_terms": [], "name": "XkdX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010023": {"description": "KdsC family", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "KdsC_fam", "pathway_ids": ["PWY-7674", "PWY-1269"], "pathways": ["PWY-7674:t:CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis", "PWY-1269:t:CMP-3-deoxy-D-manno-octulosonate biosynthesis"], "type": "Family"}, "IPR010024": {"description": "Conserved hypothetical protein CHP1671", "go_ids": [], "go_terms": [], "name": "CHP16711", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010025": {"description": "HAD-superfamily phosphatase, subfamily IIIB, AphA", "go_ids": ["GO:0003993", "GO:0030288"], "go_terms": ["GO:0003993:acid phosphatase activity:F", "GO:0030288:outer membrane-bounded periplasmic space:C"], "name": "HAD-SF_ppase_IIIB_AphA", "pathway_ids": ["PWY-6348"], "pathways": ["PWY-6348:t:phosphate acquisition"], "type": "Family"}, "IPR010026": {"description": "Phage holin, LL-H family", "go_ids": [], "go_terms": [], "name": "Phage_holin_LL-H", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010027": {"description": "Tail assembly protein G", "go_ids": [], "go_terms": [], "name": "Tail_assembly_G", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010028": {"description": "Acid phosphatase, plant", "go_ids": ["GO:0003993"], "go_terms": ["GO:0003993:acid phosphatase activity:F"], "name": "Acid_phosphatase_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010029": {"description": "Galactonolactone dehydrogenase", "go_ids": ["GO:0016633"], "go_terms": ["GO:0016633:galactonolactone dehydrogenase activity:F"], "name": "GL_DH", "pathway_ids": ["PWY-882", "PWY-8143"], "pathways": ["PWY-882:t:L-ascorbate biosynthesis I (plants, L-galactose pathway)", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)"], "type": "Family"}, "IPR010030": {"description": "L-gulonolactone oxidase, plant", "go_ids": [], "go_terms": [], "name": "GULO_Plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010031": {"description": "L-gulonolactone/D-arabinono-1,4-lactone oxidase-like", "go_ids": ["GO:0016899"], "go_terms": ["GO:0016899:oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor:F"], "name": "FAD_lactone_oxidase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010033": {"description": "HAD-superfamily phosphatase, subfamily IIIC", "go_ids": [], "go_terms": [], "name": "HAD_SF_ppase_IIIC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010035": {"description": "ThiS, thiamine-biosynthesis", "go_ids": [], "go_terms": [], "name": "Thi_S", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010036": {"description": "Magnesium-dependent phosphatase-1, eukaryotic/archaeal-type", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "MDP_1_eu_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010037": {"description": "FkbH domain", "go_ids": [], "go_terms": [], "name": "FkbH_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010038": {"description": "MoaD, archaeal-type", "go_ids": [], "go_terms": [], "name": "MoaD_arc-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010039": {"description": "Capsule biosynthesis phosphatase", "go_ids": [], "go_terms": [], "name": "EcbF_BcbF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010043": {"description": "Bifunctional uridylyltransferase/uridylyl-removing enzyme", "go_ids": ["GO:0008773"], "go_terms": ["GO:0008773:[protein-PII] uridylyltransferase activity:F"], "name": "GlnD", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I"], "type": "Family"}, "IPR010044": {"description": "Methylthioadenosine phosphorylase (MTAP)", "go_ids": ["GO:0017061"], "go_terms": ["GO:0017061:S-methyl-5-thioadenosine phosphorylase activity:F"], "name": "MTAP", "pathway_ids": ["PWY-8130", "PWY-6756", "R-DRE-1237112", "R-SCE-1237112", "R-BTA-1237112", "R-SPO-1237112", "R-HSA-8950505", "R-MMU-1237112", "R-CEL-1237112", "R-DME-1237112", "R-HSA-1237112"], "pathways": ["PWY-8130:t:5'-deoxyadenosine degradation I", "PWY-6756:t:S-methyl-5'-thioadenosine degradation II", "R-DRE-1237112:r:Methionine salvage pathway", "R-SCE-1237112:r:Methionine salvage pathway", "R-BTA-1237112:r:Methionine salvage pathway", "R-SPO-1237112:r:Methionine salvage pathway", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-1237112:r:Methionine salvage pathway", "R-CEL-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-HSA-1237112:r:Methionine salvage pathway"], "type": "Family"}, "IPR010045": {"description": "Phosphopentomutase", "go_ids": ["GO:0000287", "GO:0005737", "GO:0008973", "GO:0009117", "GO:0043094"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0005737:cytoplasm:C", "GO:0008973:phosphopentomutase activity:F", "GO:0009117:nucleotide metabolic process:P", "GO:0043094:metabolic compound salvage:P"], "name": "DeoB", "pathway_ids": ["PWY-7180"], "pathways": ["PWY-7180:t:2-deoxy-alpha-D-ribose 1-phosphate degradation"], "type": "Family"}, "IPR010046": {"description": "Oxidoreductase alpha (molybdopterin) subunit", "go_ids": ["GO:0008863", "GO:0030151", "GO:0051539"], "go_terms": ["GO:0008863:formate dehydrogenase (NAD+) activity:F", "GO:0030151:molybdenum ion binding:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Mopterin_OxRdtse_a_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010047": {"description": "Ni-containing CO dehydrogenase", "go_ids": ["GO:0043885", "GO:0006091", "GO:0016151", "GO:0051539"], "go_terms": ["GO:0043885:anaerobic carbon-monoxide dehydrogenase activity:F", "GO:0006091:generation of precursor metabolites and energy:P", "GO:0016151:nickel cation binding:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "CODH", "pathway_ids": ["PWY-5372", "PWY-6780"], "pathways": ["PWY-5372:t:carbon tetrachloride degradation II", "PWY-6780:t:hydrogen production VI"], "type": "Family"}, "IPR010048": {"description": "Hydroxylamine reductase", "go_ids": ["GO:0005737", "GO:0016661", "GO:0051536"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0016661:oxidoreductase activity, acting on other nitrogenous compounds as donors:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Hydroxylam_reduct", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010049": {"description": "MTA/SAH nucleosidase", "go_ids": ["GO:0008782", "GO:0008930", "GO:0009164", "GO:0033353"], "go_terms": ["GO:0008782:adenosylhomocysteine nucleosidase activity:F", "GO:0008930:methylthioadenosine nucleosidase activity:F", "GO:0009164:nucleoside catabolic process:P", "GO:0033353:L-methionine cycle:P"], "name": "MTA_SAH_Nsdase", "pathway_ids": ["PWY-6154", "PWY-8131", "PWY-6151", "PWY-6153"], "pathways": ["PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-8131:t:5'-deoxyadenosine degradation II", "PWY-6151:t:S-adenosyl-L-methionine salvage I", "PWY-6153:t:autoinducer AI-2 biosynthesis I"], "type": "Family"}, "IPR010050": {"description": "5-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative", "go_ids": [], "go_terms": [], "name": "MTA_SAH_nuc_hyp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010051": {"description": "Periplasmic nitrate reductase, large subunit", "go_ids": ["GO:0008940", "GO:0030151"], "go_terms": ["GO:0008940:nitrate reductase activity:F", "GO:0030151:molybdenum ion binding:F"], "name": "Periplasm_NO3_reductase_lsu", "pathway_ids": ["PWY-5674"], "pathways": ["PWY-5674:t:nitrate reduction IV (dissimilatory)"], "type": "Family"}, "IPR010052": {"description": "Type II secretion system protein GspI", "go_ids": ["GO:0015627", "GO:0015628"], "go_terms": ["GO:0015627:type II protein secretion system complex:C", "GO:0015628:protein secretion by the type II secretion system:P"], "name": "T2SS_protein-GspI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010054": {"description": "Type II secretion system protein GspG", "go_ids": ["GO:0015627", "GO:0015628"], "go_terms": ["GO:0015627:type II protein secretion system complex:C", "GO:0015628:protein secretion by the type II secretion system:P"], "name": "Type2_sec_GspG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010055": {"description": "Type II secretion system protein GspJ", "go_ids": ["GO:0015627", "GO:0015628"], "go_terms": ["GO:0015627:type II protein secretion system complex:C", "GO:0015628:protein secretion by the type II secretion system:P"], "name": "T2SS_protein-GspJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010056": {"description": "Phage replisome organiser, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Phage_rep_org__N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010057": {"description": "HTH-type transcriptional regulator Rgg, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Transcription_activator_Rgg_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010058": {"description": "Uridine phosphorylase", "go_ids": ["GO:0004850", "GO:0005737", "GO:0009166"], "go_terms": ["GO:0004850:uridine phosphorylase activity:F", "GO:0005737:cytoplasm:C", "GO:0009166:nucleotide catabolic process:P"], "name": "Uridine_phosphorylase", "pathway_ids": ["PWY-5532"], "pathways": ["PWY-5532:t:nucleoside and nucleotide degradation (archaea)"], "type": "Family"}, "IPR010059": {"description": "Uridine phosphorylase, eukaryotic", "go_ids": ["GO:0004850", "GO:0005737", "GO:0009166"], "go_terms": ["GO:0004850:uridine phosphorylase activity:F", "GO:0005737:cytoplasm:C", "GO:0009166:nucleotide catabolic process:P"], "name": "Uridine_phosphorylase_euk", "pathway_ids": ["PWY-5532", "R-CEL-73614", "R-MMU-73614", "R-HSA-73621", "R-HSA-73614", "R-MMU-73621", "R-CEL-73621"], "pathways": ["PWY-5532:t:nucleoside and nucleotide degradation (archaea)", "R-CEL-73614:r:Pyrimidine salvage", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-CEL-73621:r:Pyrimidine catabolism"], "type": "Family"}, "IPR010060": {"description": "Non-ribosomal peptide synthase", "go_ids": [], "go_terms": [], "name": "NRPS_synth", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010061": {"description": "Methylmalonate-semialdehyde dehydrogenase", "go_ids": ["GO:0004491"], "go_terms": ["GO:0004491:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity:F"], "name": "MeMal-semiAld_DH", "pathway_ids": ["PWY-5642", "R-DDI-70895", "R-HSA-70895", "R-DME-70895", "R-MMU-70895", "R-CEL-70895", "R-RNO-70895"], "pathways": ["PWY-5642:t:2,4-dinitrotoluene degradation", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-DME-70895:r:Branched-chain amino acid catabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Family"}, "IPR010062": {"description": "5,10-methenyltetrahydromethanopterin hydrogenase", "go_ids": ["GO:0019386", "GO:0047068"], "go_terms": ["GO:0019386:methanogenesis, from carbon dioxide:P", "GO:0047068:N5,N10-methenyltetrahydromethanopterin hydrogenase activity:F"], "name": "HMD_", "pathway_ids": ["PWY-7784"], "pathways": ["PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)"], "type": "Family"}, "IPR010063": {"description": "H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein", "go_ids": [], "go_terms": [], "name": "HMDII/III", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010064": {"description": "Bacteriophage HK97-gp10, putative tail-component", "go_ids": [], "go_terms": [], "name": "HK97-gp10_tail", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010065": {"description": "Amino acid ABC transporter, permease protein, 3-TM domain", "go_ids": ["GO:0016020", "GO:0071705", "GO:0022857", "GO:0043190"], "go_terms": ["GO:0016020:membrane:C", "GO:0071705:nitrogen compound transport:P", "GO:0022857:transmembrane transporter activity:F", "GO:0043190:ATP-binding cassette (ABC) transporter complex:C"], "name": "AA_ABC_transptr_permease_3TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010067": {"description": "Aliphatic sulfonates-binding protein", "go_ids": ["GO:0016020", "GO:0042626"], "go_terms": ["GO:0016020:membrane:C", "GO:0042626:ATPase-coupled transmembrane transporter activity:F"], "name": "ABC_SsuA_sub-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010068": {"description": "Taurine ABC transporter, substrate-binding protein TauA", "go_ids": ["GO:0042597"], "go_terms": ["GO:0042597:periplasmic space:C"], "name": "Peri-bd_TauA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010069": {"description": "Toxin CdiA-like, Filamentous hemagglutinin motif repeats", "go_ids": [], "go_terms": [], "name": "CdiA_FHA1_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010070": {"description": "Sporulation protein YjcZ-like", "go_ids": [], "go_terms": [], "name": "YjcZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010071": {"description": "Amino acid adenylation domain", "go_ids": [], "go_terms": [], "name": "AA_adenyl_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010072": {"description": "D-alanine--D-alanyl carrier protein ligase", "go_ids": ["GO:0005524", "GO:0070395", "GO:0047473"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0070395:lipoteichoic acid biosynthetic process:P", "GO:0047473:D-alanine [D-alanyl carrier protein] ligase activity:F"], "name": "DltA", "pathway_ids": ["PWY-7817", "PWY-8443", "PWY-8343", "PWY-8040", "PWY-7816", "PWY-7818", "PWY-7815"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8443:t:cyclosporin A biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"], "type": "Family"}, "IPR010073": {"description": "Phosphoribosylformylglycinamidine synthase PurL", "go_ids": ["GO:0004642", "GO:0006189"], "go_terms": ["GO:0004642:phosphoribosylformylglycinamidine synthase activity:F", "GO:0006189:'de novo' IMP biosynthetic process:P"], "name": "PurL_large", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-MMU-73817", "R-CEL-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis"], "type": "Family"}, "IPR010074": {"description": "Phosphoribosylformylglycinamidine subunit PurL", "go_ids": ["GO:0004642", "GO:0006189"], "go_terms": ["GO:0004642:phosphoribosylformylglycinamidine synthase activity:F", "GO:0006189:'de novo' IMP biosynthetic process:P"], "name": "PRibForGlyAmidine_synth_PurL", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis"], "type": "Family"}, "IPR010075": {"description": "Phosphoribosylformylglycinamidine synthase subunit PurQ", "go_ids": ["GO:0004642", "GO:0006189"], "go_terms": ["GO:0004642:phosphoribosylformylglycinamidine synthase activity:F", "GO:0006189:'de novo' IMP biosynthetic process:P"], "name": "PRibForGlyAmidine_synth_PurQ", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "PWY-5921"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "PWY-5921:t:glutaminyl-tRNAgln biosynthesis via transamidation"], "type": "Family"}, "IPR010076": {"description": "Pimeloyl-[acyl-carrier protein] methyl ester esterase", "go_ids": ["GO:0009102", "GO:0052689"], "go_terms": ["GO:0009102:biotin biosynthetic process:P", "GO:0052689:carboxylic ester hydrolase activity:F"], "name": "BioH", "pathway_ids": ["PWY-6519"], "pathways": ["PWY-6519:t:8-amino-7-oxononanoate biosynthesis I"], "type": "Family"}, "IPR010077": {"description": "Herpes virus tegument protein", "go_ids": ["GO:0019033", "GO:0075733"], "go_terms": ["GO:0019033:viral tegument:C", "GO:0075733:intracellular transport of virus:P"], "name": "Herpes_virus_tegument", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010078": {"description": "Pur operon repressor", "go_ids": ["GO:0003677", "GO:0045892", "GO:0045982"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0045982:negative regulation of purine nucleobase metabolic process:P"], "name": "PurR_Bsub", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010079": {"description": "Xanthine phosphoribosyltransferase", "go_ids": ["GO:0016763", "GO:0043101", "GO:0046110"], "go_terms": ["GO:0016763:pentosyltransferase activity:F", "GO:0043101:purine-containing compound salvage:P", "GO:0046110:xanthine metabolic process:P"], "name": "Xanthine_PRibTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010080": {"description": "Thioester reductase-like domain", "go_ids": [], "go_terms": [], "name": "Thioester_reductase-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010081": {"description": "Diaminopropionate ammonia-lyase", "go_ids": ["GO:0008838", "GO:0030170"], "go_terms": ["GO:0008838:diaminopropionate ammonia-lyase activity:F", "GO:0030170:pyridoxal phosphate binding:F"], "name": "DiNH2opropionate_NH3_lyase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010083": {"description": "Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA", "go_ids": ["GO:0005737", "GO:0006633", "GO:0019171"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006633:fatty acid biosynthetic process:P", "GO:0019171:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity:F"], "name": "FabA", "pathway_ids": ["PWY-7664", "PWY-7858", "PWY-8175", "PWY-8174", "PWY-8203", "PWY-7663", "PWYG-321", "PWY-5971", "PWY-7388", "PWY-5973", "PWY-8427", "PWY-5989", "PWY-8279", "PWY-8280", "PWY-6519", "PWY-6282", "PWY-8173"], "pathways": ["PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWYG-321:t:mycolate biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-8279:t:palmitate biosynthesis III", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis"], "type": "Family"}, "IPR010084": {"description": "Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ", "go_ids": ["GO:0006633", "GO:0016836"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P", "GO:0016836:hydro-lyase activity:F"], "name": "FabZ", "pathway_ids": ["PWY-7664", "PWY-8175", "PWY-7858", "PWY-8174", "PWY-8203", "PWY-7663", "PWYG-321", "PWY-5971", "PWY-7388", "PWY-5973", "PWY-8427", "PWY-5989", "PWY-8279", "PWY-8280", "PWY-6519", "PWY-6282", "PWY-8173"], "pathways": ["PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWYG-321:t:mycolate biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-8279:t:palmitate biosynthesis III", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis"], "type": "Family"}, "IPR010085": {"description": "Crotonyl-CoA reductase", "go_ids": ["GO:0043880"], "go_terms": ["GO:0043880:crotonyl-CoA reductase activity:F"], "name": "Crot_CoA_red", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010086": {"description": "Flavodoxin, long chain", "go_ids": ["GO:0010181"], "go_terms": ["GO:0010181:FMN binding:F"], "name": "Flavodoxin_lc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010087": {"description": "Flavodoxin, short chain", "go_ids": ["GO:0010181"], "go_terms": ["GO:0010181:FMN binding:F"], "name": "Flav_short", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010088": {"description": "Ribonucleotide reductase-associated flavodoxin, putative", "go_ids": [], "go_terms": [], "name": "RNR_flavodoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010089": {"description": "Flavoprotein WrbA-like", "go_ids": ["GO:0010181", "GO:0003955"], "go_terms": ["GO:0010181:FMN binding:F", "GO:0003955:NAD(P)H dehydrogenase (quinone) activity:F"], "name": "Flavoprotein_WrbA-like", "pathway_ids": ["PWY-7999", "PWY-7731"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "PWY-7731:t:superpathway of photosynthetic hydrogen production"], "type": "Family"}, "IPR010090": {"description": "Phage tail tape measure protein", "go_ids": [], "go_terms": [], "name": "Phage_tape_meas", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010091": {"description": "Thiazolinyl imide reductase", "go_ids": [], "go_terms": [], "name": "Thiazolinyl_imide_reductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010092": {"description": "Chlorinating enzyme", "go_ids": [], "go_terms": [], "name": "Chlorin_enz", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010093": {"description": "SinI-like, DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "SinI_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010094": {"description": "Transposase (putative), N-terminal", "go_ids": [], "go_terms": [], "name": "Transposase_put_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010095": {"description": "Cas12f1-like, TNB domain", "go_ids": [], "go_terms": [], "name": "Cas12f1-like_TNB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010096": {"description": "NAD(P)H-quinone oxidoreductase, subunit N/subunit 2", "go_ids": ["GO:0008137", "GO:0042773"], "go_terms": ["GO:0008137:NADH dehydrogenase (ubiquinone) activity:F", "GO:0042773:ATP synthesis coupled electron transport:P"], "name": "NADH-Q_OxRdtase_suN/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010097": {"description": "Malate dehydrogenase, type 1", "go_ids": ["GO:0030060", "GO:0006099"], "go_terms": ["GO:0030060:L-malate dehydrogenase (NAD+) activity:F", "GO:0006099:tricarboxylic acid cycle:P"], "name": "Malate_DH_type1", "pathway_ids": ["PWY-7383", "PWY-8086", "PWY-1622", "PWY-6728", "PWY-7115", "PWY-561", "PWY-5690", "PWY-5392", "PWY-6969", "R-MMU-9837999", "R-CEL-9837999", "R-HSA-9856872", "R-BTA-71403", "R-RNO-9837999", "R-BTA-9856872", "R-CEL-9856872", "R-SCE-9856872", "R-SPO-71403", "R-CEL-71403", "R-MMU-71403", "R-BTA-9837999", "R-SCE-71403", "R-SCE-9837999", "R-MMU-9856872", "R-SPO-9837999", "R-RNO-9856872", "R-HSA-9837999", "R-RNO-71403", "R-SPO-9856872", "R-HSA-71403"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-6728:t:methylaspartate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-9856872:r:Malate-aspartate shuttle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-9856872:r:Malate-aspartate shuttle", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-SCE-9856872:r:Malate-aspartate shuttle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-9856872:r:Malate-aspartate shuttle", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Family"}, "IPR010098": {"description": "Glycyl radical enzyme, PFL2/glycerol dehydratase family", "go_ids": [], "go_terms": [], "name": "PFL2/GDeHydtase_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010099": {"description": "Epimerase family protein SDR39U1", "go_ids": [], "go_terms": [], "name": "SDR39U1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010100": {"description": "TonB-dependent copper receptor", "go_ids": [], "go_terms": [], "name": "TonB-dep_Cu_rcpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010101": {"description": "TonB-dependent vitamin B12 transporter BtuB", "go_ids": ["GO:0015889", "GO:0016020", "GO:0015420"], "go_terms": ["GO:0015889:cobalamin transport:P", "GO:0016020:membrane:C", "GO:0015420:ABC-type vitamin B12 transporter activity:F"], "name": "B12_transptr_BtuB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010102": {"description": "Succinate semialdehyde dehydrogenase", "go_ids": ["GO:0009450", "GO:0009013"], "go_terms": ["GO:0009450:GABA catabolic process:P", "GO:0009013:succinate-semialdehyde dehydrogenase [NAD(P)+] activity:F"], "name": "Succ_semiAld_DH", "pathway_ids": ["R-RNO-916853", "R-SPO-916853", "R-HSA-916853", "R-SCE-916853", "R-MMU-916853"], "pathways": ["R-RNO-916853:r:Degradation of GABA", "R-SPO-916853:r:Degradation of GABA", "R-HSA-916853:r:Degradation of GABA", "R-SCE-916853:r:Degradation of GABA", "R-MMU-916853:r:Degradation of GABA"], "type": "Family"}, "IPR010103": {"description": "Clustered lipoprotein, Treponema denticola-type", "go_ids": [], "go_terms": [], "name": "Clustered_lipoprot_TREDE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010104": {"description": "Bacterial TonB-dependent receptor", "go_ids": [], "go_terms": [], "name": "TonB_rcpt_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010105": {"description": "TonB-dependent siderophore receptor", "go_ids": ["GO:0009279", "GO:0038023", "GO:0015891", "GO:0015343"], "go_terms": ["GO:0009279:cell outer membrane:C", "GO:0038023:signaling receptor activity:F", "GO:0015891:siderophore transport:P", "GO:0015343:siderophore-iron transmembrane transporter activity:F"], "name": "TonB_sidphr_rcpt", "pathway_ids": ["R-HSA-9638334", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR010106": {"description": "Recombination-promoting nuclease RpnA", "go_ids": [], "go_terms": [], "name": "RpnA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010107": {"description": "Glutamate decarboxylase", "go_ids": ["GO:0004351", "GO:0006536", "GO:0030170"], "go_terms": ["GO:0004351:glutamate decarboxylase activity:F", "GO:0006536:glutamate metabolic process:P", "GO:0030170:pyridoxal phosphate binding:F"], "name": "Glutamate_decarboxylase", "pathway_ids": ["PWY-8346"], "pathways": ["PWY-8346:t:GABA shunt II"], "type": "Family"}, "IPR010108": {"description": "Lycopene cyclase, beta/epsilon", "go_ids": ["GO:0016117", "GO:0016705"], "go_terms": ["GO:0016117:carotenoid biosynthetic process:P", "GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F"], "name": "Lycopene_cyclase_b/e", "pathway_ids": ["PWY-7591", "PWY-6279", "PWY-5947", "PWY-7938", "PWY-7947", "PWY-5946", "PWY-7939", "PWY-5943"], "pathways": ["PWY-7591:t:okenone biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-5947:t:lutein biosynthesis", "PWY-7938:t:isorenieratene biosynthesis I (actinobacteria)", "PWY-7947:t:flexixanthin biosynthesis", "PWY-5946:t:alpha-carotene biosynthesis", "PWY-7939:t:chlorobactene biosynthesis", "PWY-5943:t:beta-carotene biosynthesis"], "type": "Family"}, "IPR010109": {"description": "Citrate synthase, eukaryotic-type", "go_ids": ["GO:0006099", "GO:0006101"], "go_terms": ["GO:0006099:tricarboxylic acid cycle:P", "GO:0006101:citrate metabolic process:P"], "name": "Citrate_synthase_euk", "pathway_ids": ["R-DDI-9837999", "R-HSA-9854311", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-9854311", "R-BTA-71403", "R-DME-9837999", "R-DRE-9854311", "R-GGA-372987", "R-SSC-9854311", "R-RNO-9837999", "R-DRE-71403", "R-DRE-9837999", "R-SSC-71403", "R-SPO-71403", "R-CEL-71403", "R-HSA-1268020", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-71403", "R-SCE-9837999", "R-MMU-71403", "R-SSC-9837999", "R-DME-71403", "R-HSA-9837999", "R-DDI-71403", "R-RNO-71403", "R-XTR-71403", "R-HSA-71403", "R-XTR-9837999"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9837999:r:Mitochondrial protein degradation"], "type": "Family"}, "IPR010110": {"description": "Shikimate dehydrogenase, AroM-type", "go_ids": ["GO:0004764", "GO:0005737"], "go_terms": ["GO:0004764:shikimate 3-dehydrogenase (NADP+) activity:F", "GO:0005737:cytoplasm:C"], "name": "Shikimate_DH_AroM-type", "pathway_ids": ["PWY-6164", "PWY-6707", "PWY-6163", "PWY-6416"], "pathways": ["PWY-6164:t:3-dehydroquinate biosynthesis I", "PWY-6707:t:gallate biosynthesis", "PWY-6163:t:chorismate biosynthesis from 3-dehydroquinate", "PWY-6416:t:quinate degradation II"], "type": "Domain"}, "IPR010111": {"description": "Kynureninase", "go_ids": ["GO:0005737", "GO:0006569", "GO:0009435", "GO:0030170", "GO:0030429"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006569:L-tryptophan catabolic process:P", "GO:0009435:NAD+ biosynthetic process:P", "GO:0030170:pyridoxal phosphate binding:F", "GO:0030429:kynureninase activity:F"], "name": "Kynureninase", "pathway_ids": ["PWY-6309", "PWY-7765", "PWY-5651", "R-HSA-71240", "R-RNO-71240", "R-DDI-71240", "R-CEL-71240", "R-SCE-71240", "R-MMU-71240"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-5651:t:L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde", "R-HSA-71240:r:Tryptophan catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-DDI-71240:r:Tryptophan catabolism", "R-CEL-71240:r:Tryptophan catabolism", "R-SCE-71240:r:Tryptophan catabolism", "R-MMU-71240:r:Tryptophan catabolism"], "type": "Family"}, "IPR010112": {"description": "Anthranilate synthase, bacteria", "go_ids": ["GO:0000162", "GO:0004049"], "go_terms": ["GO:0000162:L-tryptophan biosynthetic process:P", "GO:0004049:anthranilate synthase activity:F"], "name": "TrpE-G_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010113": {"description": "Nif-specific regulatory protein", "go_ids": ["GO:0009399", "GO:0006355", "GO:0003700"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "Nif-specific_regulatory_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010114": {"description": "DNA-binding transcriptional regulator NtrC", "go_ids": ["GO:0000156", "GO:0000160", "GO:0003677", "GO:0005524", "GO:0006808"], "go_terms": ["GO:0000156:phosphorelay response regulator activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F", "GO:0006808:regulation of nitrogen utilization:P"], "name": "Transcript_reg_NtrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010115": {"description": "Phosphoenolpyruvate transferase/2-phospho-L-lactate transferase", "go_ids": ["GO:0043743", "GO:0000287"], "go_terms": ["GO:0043743:LPPG:FO 2-phospho-L-lactate transferase activity:F", "GO:0000287:magnesium ion binding:F"], "name": "FbiA/CofD", "pathway_ids": ["PWY-8113", "PWY-8112", "PWY-5198"], "pathways": ["PWY-8113:t:3PG-factor 420 biosynthesis", "PWY-8112:t:factor 420 biosynthesis I (archaea)", "PWY-5198:t:factor 420 biosynthesis II (mycobacteria)"], "type": "Family"}, "IPR010116": {"description": "Anthranilate synthase component I, archaeal type", "go_ids": ["GO:0000162", "GO:0004049"], "go_terms": ["GO:0000162:L-tryptophan biosynthetic process:P", "GO:0004049:anthranilate synthase activity:F"], "name": "Anthranilate_synth_I_arc_typ", "pathway_ids": ["PWY-6661", "PWY-5958"], "pathways": ["PWY-6661:t:4-hydroxy-2(1H)-quinolone biosynthesis", "PWY-5958:t:acridone alkaloid biosynthesis"], "type": "Family"}, "IPR010117": {"description": "Para-aminobenzoate synthase", "go_ids": [], "go_terms": [], "name": "PabB_fungal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010118": {"description": "Para-aminobenzoate synthase/anthranilate synthase, component I", "go_ids": [], "go_terms": [], "name": "Para-NH2Bz/anthranilate_synth", "pathway_ids": ["PWY-6661", "PWY-5958"], "pathways": ["PWY-6661:t:4-hydroxy-2(1H)-quinolone biosynthesis", "PWY-5958:t:acridone alkaloid biosynthesis"], "type": "Family"}, "IPR010119": {"description": "Gluconeogenesis factor", "go_ids": [], "go_terms": [], "name": "Gluconeogen_factor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010120": {"description": "Probable glutamyl-tRNA(Gln) amidotransferase subunit C, archaea", "go_ids": [], "go_terms": [], "name": "Glu-ADT_subunit_C_archaea", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010121": {"description": "Pyruvate, phosphate dikinase", "go_ids": ["GO:0050242", "GO:0006090"], "go_terms": ["GO:0050242:pyruvate, phosphate dikinase activity:F", "GO:0006090:pyruvate metabolic process:P"], "name": "Pyruvate_phosphate_dikinase", "pathway_ids": ["PWY-7115", "PWY-7117", "PWY-241", "PWY-6549"], "pathways": ["PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-241:t:C4 photosynthetic carbon assimilation cycle, NADP-ME type", "PWY-6549:t:nitrogen remobilization from senescing leaves"], "type": "Family"}, "IPR010122": {"description": "Hydroxymethylglutaryl-CoA synthase, eukaryotic", "go_ids": ["GO:0004421", "GO:0008299"], "go_terms": ["GO:0004421:hydroxymethylglutaryl-CoA synthase activity:F", "GO:0008299:isoprenoid biosynthetic process:P"], "name": "HMG_CoA_synthase_euk", "pathway_ids": ["PWY-7524", "PWY-7391", "PWY-922", "PWY-8125", "PWY-6174", "PWY-7571", "R-SCE-9969896", "R-HSA-1989781", "R-DDI-9837999", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-77111", "R-RNO-77111", "R-CEL-9969896", "R-MMU-77111", "R-DDI-77111", "R-RNO-9837999", "R-MMU-9969896", "R-HSA-77111", "R-SPO-77111", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-RNO-9969896", "R-SCE-77111", "R-SSC-9837999", "R-DDI-9969896", "R-HSA-9837999", "R-SSC-77111", "R-HSA-2426168", "R-CEL-77111", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["PWY-7524:t:mevalonate pathway III (Thermoplasma)", "PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "PWY-8125:t:mevalonate pathway IV (archaea)", "PWY-6174:t:mevalonate pathway II (haloarchaea)", "PWY-7571:t:ferrichrome A biosynthesis", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-77111:r:Synthesis of Ketone Bodies", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-CEL-9969896:r:Lanosterol biosynthesis", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-DDI-77111:r:Synthesis of Ketone Bodies", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-SPO-77111:r:Synthesis of Ketone Bodies", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-SCE-77111:r:Synthesis of Ketone Bodies", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-77111:r:Synthesis of Ketone Bodies", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-CEL-77111:r:Synthesis of Ketone Bodies", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR010123": {"description": "Poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit", "go_ids": [], "go_terms": [], "name": "PHA_synth_III_E", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010125": {"description": "Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit", "go_ids": ["GO:0016746", "GO:0042619"], "go_terms": ["GO:0016746:acyltransferase activity:F", "GO:0042619:poly-hydroxybutyrate biosynthetic process:P"], "name": "PHA_synth_III_C", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 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"Family"}, "IPR010161": {"description": "Peptidase M20B, tripeptide aminopeptidase", "go_ids": ["GO:0006518", "GO:0008270", "GO:0045148"], "go_terms": ["GO:0006518:peptide metabolic process:P", "GO:0008270:zinc ion binding:F", "GO:0045148:tripeptide aminopeptidase activity:F"], "name": "Peptidase_M20B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010162": {"description": "Methylformimidoylglutamase-like", "go_ids": [], "go_terms": [], "name": "MFMMG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010163": {"description": "CRISPR-associated CARF protein Csa3", "go_ids": [], "go_terms": [], "name": "Csa3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010164": {"description": "Ornithine aminotransferase", "go_ids": ["GO:0004587"], "go_terms": ["GO:0004587:L-ornithine transaminase activity:F"], "name": "Orn_aminotrans", "pathway_ids": ["PWY-3341", "PWY-6922", "PWY-8187", "R-HSA-8964539", "R-DME-8964539", "R-DDI-8964539", "R-SPO-8964539", 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{"description": "Transcriptional regulator SarA/Rot domain", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "SarA/Rot_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010167": {"description": "Amino-acid N-acetyltransferase", "go_ids": ["GO:0004042", "GO:0005737", "GO:0006526"], "go_terms": ["GO:0004042:L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor:F", "GO:0005737:cytoplasm:C", "GO:0006526:L-arginine biosynthetic process:P"], "name": "NH2A_AcTrfase", "pathway_ids": ["PWY-5154"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Family"}, "IPR010169": {"description": "Acetylornithine deacetylase ArgE", "go_ids": ["GO:0019213", "GO:0006526"], "go_terms": ["GO:0019213:deacetylase activity:F", "GO:0006526:L-arginine biosynthetic process:P"], "name": "AcOrn-deacetyl", "pathway_ids": ["PWY-5154"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Family"}, "IPR010171": {"description": "CRISPR system endoribonuclease Csx1", "go_ids": [], "go_terms": [], "name": "CRISPR_Csx1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010172": {"description": "CRISPR-associated protein, TM1791", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_TM1791", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010173": {"description": "CRISPR-associated protein Csm5", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Csm5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010174": {"description": "Succinyl-diaminopimelate desuccinylase, DapE", "go_ids": ["GO:0009014", "GO:0009085"], "go_terms": ["GO:0009014:succinyl-diaminopimelate desuccinylase activity:F", "GO:0009085:L-lysine biosynthetic process:P"], "name": "Succinyl-DAP_deSuclase_DapE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010175": {"description": "[LysW]-lysine/[LysW]-ornithine hydrolase", "go_ids": ["GO:0008270", "GO:0009085", "GO:0016811", "GO:0050897"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0009085:L-lysine biosynthetic process:P", "GO:0016811:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides:F", "GO:0050897:cobalt ion binding:F"], "name": "LysK", "pathway_ids": ["PWY-7400", "PWY-3081"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-3081:t:L-lysine biosynthesis V"], "type": "Family"}, "IPR010176": {"description": "CxxxxCH...CXXCH motif, Geobacter sulfurreducens", "go_ids": [], "go_terms": [], "name": "C4xCH_C2xCH_motif_GEOSU", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010177": {"description": "Doubled CXXCH motif", "go_ids": [], "go_terms": [], "name": "Paired_CXXCH_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010178": {"description": "Lipoprotein intramolecular transacylase Lit", "go_ids": [], "go_terms": [], "name": "Lit", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010179": {"description": "CRISPR-associated protein Cse3", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cse3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010180": {"description": "CRISPR-associated protein, CXXC-CXXC", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_CXXC-CXXC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010181": {"description": "CGCAxxGCC motif", "go_ids": [], "go_terms": [], "name": "CGCAxxGCC_motif", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010182": {"description": "N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase/Succinyl-diaminopimelate desuccinylase", "go_ids": [], "go_terms": [], "name": "ArgE/DapE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010183": {"description": "Bacteriophage lambda, Recombination protein bet", "go_ids": ["GO:0006310"], "go_terms": ["GO:0006310:DNA recombination:P"], "name": "Phage_lambda_Bet", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010184": {"description": "CRISPR-associated protein, MJ0385", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_MJ0385", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010185": {"description": "NADPH-dependent F420 reductase", "go_ids": ["GO:0016651", "GO:0006740", "GO:0050661", "GO:0070967"], "go_terms": ["GO:0016651:oxidoreductase activity, acting on NAD(P)H:F", "GO:0006740:NADPH regeneration:P", "GO:0050661:NADP binding:F", "GO:0070967:coenzyme F420 binding:F"], "name": "NpdG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010186": {"description": "Glycine reductase, selenoprotein B", "go_ids": ["GO:0030699", "GO:0030700", "GO:0050485"], "go_terms": ["GO:0030699:glycine reductase activity:F", "GO:0030700:glycine reductase complex:C", "GO:0050485:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor:F"], "name": "Gly_red_sel_B", "pathway_ids": ["PWY-8303", "PWY-8015"], "pathways": ["PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-8015:t:glycine degradation (reductive Stickland reaction)"], "type": "Family"}, "IPR010187": {"description": "Selenoprotein B, glycine/betaine/sarcosine/D-proline reductase", "go_ids": ["GO:0050485"], "go_terms": ["GO:0050485:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor:F"], "name": "Various_sel_PB", "pathway_ids": ["PWY-8303", "PWY-8015"], "pathways": ["PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-8015:t:glycine degradation (reductive Stickland reaction)"], "type": "Family"}, "IPR010188": {"description": "HisA/PriA, Actinobacteria", "go_ids": ["GO:0000105", "GO:0000162", "GO:0003949", "GO:0004640", "GO:0005737"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0000162:L-tryptophan biosynthetic process:P", "GO:0003949:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity:F", "GO:0004640:phosphoribosylanthranilate isomerase activity:F", "GO:0005737:cytoplasm:C"], "name": "HisA/PriA_Actinobacteria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010189": {"description": "Shikimate kinase, archaea", "go_ids": ["GO:0004765", "GO:0005737", "GO:0009073"], "go_terms": ["GO:0004765:shikimate kinase activity:F", "GO:0005737:cytoplasm:C", "GO:0009073:aromatic amino acid biosynthetic process:P"], "name": "SK_arc", "pathway_ids": ["PWY-6163"], "pathways": ["PWY-6163:t:chorismate biosynthesis from 3-dehydroquinate"], "type": "Family"}, "IPR010190": {"description": "Diaminopimelate dehydrogenase, Ddh", "go_ids": ["GO:0047850", "GO:0009085"], "go_terms": ["GO:0047850:diaminopimelate dehydrogenase activity:F", "GO:0009085:L-lysine biosynthetic process:P"], "name": "Diaminopimelate_DH_Ddh", "pathway_ids": ["PWY-2942"], "pathways": ["PWY-2942:t:L-lysine biosynthesis III"], "type": "Family"}, "IPR010191": {"description": "IMP cyclohydrolase", "go_ids": ["GO:0003937", "GO:0006164", "GO:0006188"], "go_terms": ["GO:0003937:IMP cyclohydrolase activity:F", "GO:0006164:purine nucleotide biosynthetic process:P", "GO:0006188:IMP biosynthetic process:P"], "name": "IMP_cyclohydrolase", "pathway_ids": ["PWY-6123", "PWY-7234", "PWY-6124"], "pathways": ["PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-7234:t:inosine-5'-phosphate biosynthesis III", "PWY-6124:t:inosine-5'-phosphate biosynthesis II"], "type": "Family"}, "IPR010192": {"description": "2-succinylbenzoate--CoA ligase", "go_ids": ["GO:0005524", "GO:0008756", "GO:0009234"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0008756:o-succinylbenzoate-CoA ligase activity:F", "GO:0009234:menaquinone biosynthetic process:P"], "name": "MenE", "pathway_ids": ["PWY-5837"], "pathways": ["PWY-5837:t:2-carboxy-1,4-naphthoquinol biosynthesis"], "type": "Family"}, "IPR010193": {"description": "Serine-protein kinase RsbW", "go_ids": ["GO:0004674", "GO:0005524", "GO:0006468", "GO:0016989", "GO:0045892"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P", "GO:0016989:sigma factor antagonist activity:F", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "RsbW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010194": {"description": "Anti-sigma F factor", "go_ids": ["GO:0004674", "GO:0005524", "GO:0006468", "GO:0016989", "GO:0045892", "GO:0042174"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P", "GO:0016989:sigma factor antagonist activity:F", "GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0042174:negative regulation of sporulation resulting in formation of a cellular spore:P"], "name": "Anti-sigma_F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010195": {"description": "Uncharacterised 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"GO:0019344", "GO:0050660", "GO:0010181"], "go_terms": ["GO:0004783:sulfite reductase (NADPH) activity:F", "GO:0019344:L-cysteine biosynthetic process:P", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0010181:FMN binding:F"], "name": "CysJ", "pathway_ids": ["PWY-6683"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III"], "type": "Family"}, "IPR010200": {"description": "HflC", "go_ids": ["GO:0016020", "GO:0052547"], "go_terms": ["GO:0016020:membrane:C", "GO:0052547:regulation of peptidase activity:P"], "name": "HflC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010201": {"description": "HflK", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "HflK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010203": {"description": "Regulator of ribonuclease activity A", "go_ids": ["GO:0008428", "GO:0051252"], "go_terms": ["GO:0008428:ribonuclease inhibitor activity:F", "GO:0051252:regulation of RNA metabolic process:P"], "name": "RraA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010204": {"description": "Na(+)-translocating NADH-quinone reductase subunit C", "go_ids": ["GO:0006814", "GO:0010181", "GO:0016020", "GO:0016655"], "go_terms": ["GO:0006814:sodium ion transport:P", "GO:0010181:FMN binding:F", "GO:0016020:membrane:C", "GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F"], "name": "NqrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010205": {"description": "Na(+)-translocating NADH-quinone reductase subunit F", "go_ids": ["GO:0006814", "GO:0016020", "GO:0016655", "GO:0051537"], "go_terms": ["GO:0006814:sodium ion transport:P", "GO:0016020:membrane:C", "GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F", "GO:0051537:2 iron, 2 sulfur cluster binding:F"], "name": "NqrF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010206": {"description": "Poly(A) polymerase I", "go_ids": ["GO:0003723", "GO:0043633", "GO:1990817"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0043633:polyadenylation-dependent RNA catabolic process:P", "GO:1990817:poly(A) RNA polymerase activity:F"], "name": "PolA_pol_I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010207": {"description": "Ion-translocating oxidoreductase complex, RnfB/RsxB", "go_ids": ["GO:0009055", "GO:0051536"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Elect_transpt_cplx_RnfB/RsxB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010208": {"description": "Ion-translocating oxidoreductase complex, subunit RnfC/RsxC", "go_ids": ["GO:0009055", "GO:0016020", "GO:0051539"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0016020:membrane:C", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Ion_transpt_RnfC/RsxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010209": {"description": 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"R-CEL-209968:r:Thyroxine biosynthesis"], "type": "Homologous_superfamily"}, "IPR010258": {"description": "Conjugal transfer TrbG/VirB9/CagX", "go_ids": [], "go_terms": [], "name": "TrbG/VirB9/CagX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010259": {"description": "Peptidase S8 propeptide/proteinase inhibitor I9", "go_ids": [], "go_terms": [], "name": "S8pro/Inhibitor_I9", "pathway_ids": ["PWY-7884", "R-RNO-381426", "R-SPO-8964038", "R-HSA-8866427", "R-HSA-381426", "R-RNO-8957275", "R-SPO-8866427", "R-MMU-8866427", "R-MMU-381426", "R-MMU-8964038", "R-HSA-8957275", "R-SCE-8964038", "R-SCE-8866427", "R-RNO-8964038", "R-RNO-8866427", "R-MMU-8957275", "R-HSA-8964038"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SPO-8964038:r:LDL clearance", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8964038:r:LDL clearance", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SCE-8964038:r:LDL clearance", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-RNO-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964038:r:LDL clearance"], "type": "Domain"}, "IPR010260": {"description": "DNA-binding transcriptional activator AlpA", "go_ids": [], "go_terms": [], "name": "AlpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010261": {"description": "Tir chaperone protein (CesT) family", "go_ids": ["GO:0030254"], "go_terms": ["GO:0030254:protein secretion by the type III secretion system:P"], "name": "Tir_chaperone", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010262": {"description": "Arylsulfotransferase, C-terminal", "go_ids": ["GO:0004062"], "go_terms": ["GO:0004062:aryl sulfotransferase activity:F"], "name": "Arylsulfotransferase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010263": {"description": "Type VI secretion system TssK", "go_ids": [], "go_terms": [], "name": "T6SS_TssK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010264": {"description": "Plant self-incompatibility S1", "go_ids": [], "go_terms": [], "name": "Self-incomp_S1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010265": {"description": "Bacteriophage lambda, Tail tip protein M", "go_ids": [], "go_terms": [], "name": "Phage_lambda_TipM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010266": {"description": "NnrS", "go_ids": [], "go_terms": [], "name": "NnrS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010267": {"description": "Chordopoxvirus A20R", "go_ids": [], "go_terms": [], "name": "Chordopox_A20R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010268": {"description": "Archaeal PaREP1-like", "go_ids": [], "go_terms": [], "name": "PaREP1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010269": {"description": "Type VI secretion system TssC-like", "go_ids": [], "go_terms": [], "name": "T6SS_TssC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010270": {"description": "Bacteriophage P2, GpM", "go_ids": ["GO:0003677", "GO:0004519", "GO:0019069"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004519:endonuclease activity:F", "GO:0019069:viral capsid assembly:P"], "name": "Phage_P2_GpM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010271": {"description": "Toxin-coregulated pilus subunit TcpA", "go_ids": ["GO:0009289", "GO:0043230"], "go_terms": ["GO:0009289:pilus:C", "GO:0043230:extracellular organelle:C"], "name": "TcpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010272": {"description": "Type VI secretion system TssF", "go_ids": [], "go_terms": [], "name": "T6SS_TssF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010273": {"description": "Protein of unknown function DUF881", "go_ids": [], "go_terms": [], "name": "DUF881", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010274": {"description": "Orthopoxvirus A36R", "go_ids": [], "go_terms": [], "name": "Orthopox_A36R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010275": {"description": "Peptidoglycan L,D-endopeptidase MepK", "go_ids": [], "go_terms": [], "name": "MepK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010276": {"description": "Allatostatin", "go_ids": ["GO:0005184"], "go_terms": ["GO:0005184:neuropeptide hormone activity:F"], "name": "Allatostatin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010278": {"description": "Varicellovirus Gp2, glycoprotein", "go_ids": ["GO:0016020", "GO:0016032"], "go_terms": ["GO:0016020:membrane:C", "GO:0016032:viral process:P"], "name": "Varicellovirus_Gp2_glycop", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010279": {"description": "Inner membrane protein YqjD/ElaB", "go_ids": ["GO:0043022"], "go_terms": ["GO:0043022:ribosome binding:F"], "name": "YqjD/ElaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010280": {"description": "(Uracil-5)-methyltransferase family", "go_ids": ["GO:0006396", "GO:0008173"], "go_terms": ["GO:0006396:RNA processing:P", "GO:0008173:RNA methyltransferase activity:F"], "name": "U5_MeTrfase_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010281": {"description": "Protein of unknown function DUF885", "go_ids": [], "go_terms": [], "name": "DUF885", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010282": {"description": "Uncharacterised protein family HutD/Ves", "go_ids": [], "go_terms": [], "name": "Uncharacterised_HutD/Ves", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010284": {"description": "Photosystem II reaction center protein Ycf12", "go_ids": ["GO:0016020", "GO:0009523", "GO:0015979"], "go_terms": ["GO:0016020:membrane:C", "GO:0009523:photosystem II:C", "GO:0015979:photosynthesis:P"], "name": "PSII_Ycf12_core-subunit", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010285": {"description": "DNA helicase Pif1-like, DEAD-box helicase domain", "go_ids": ["GO:0003678", "GO:0000723", "GO:0006281"], "go_terms": ["GO:0003678:DNA helicase activity:F", "GO:0000723:telomere maintenance:P", "GO:0006281:DNA repair:P"], "name": "DNA_helicase_pif1-like_DEAD", "pathway_ids": ["R-RNO-171319", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR010286": {"description": "METTL16/RlmF family", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "METTL16/RlmF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010287": {"description": "Protein of unknown function DUF892, YciF-like", "go_ids": [], "go_terms": [], "name": "DUF892_YciF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010288": {"description": "Bacterial ABC transporter EcsB", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "EcsB_ABC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010290": {"description": "Transmembrane secretion effector", "go_ids": [], "go_terms": [], "name": "TM_effector", "pathway_ids": ["R-HSA-9638334"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin"], "type": "Family"}, "IPR010291": {"description": "Ion channel regulatory protein, UNC-93", "go_ids": [], "go_terms": [], "name": "Ion_channel_UNC-93", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010292": {"description": "Uncharacterised protein family CreA", "go_ids": [], "go_terms": [], "name": "Uncharacterised_CreA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010293": {"description": "Na+-dependent bicarbonate transporter superfamily", "go_ids": [], "go_terms": [], "name": "Sbt_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010294": {"description": "ADAMTS/ADAMTS-like, Spacer 1", "go_ids": [], "go_terms": [], "name": "ADAMTS_spacer1", "pathway_ids": ["R-HSA-1474228", "R-HSA-5083635", "R-RNO-1474228", "R-BTA-5173214", "R-HSA-9845619", "R-HSA-9845621", "R-HSA-1650814", "R-RNO-5173214", "R-HSA-75892", "R-HSA-5173214", "R-MMU-1650814", "R-MMU-5173214", "R-CEL-5173214", "R-BTA-1650814", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-CEL-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR010295": {"description": "Protein of unknown function DUF898", "go_ids": [], "go_terms": [], "name": "DUF898", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010296": {"description": "Protein of unknown function DUF899, thioredoxin-like", "go_ids": [], "go_terms": [], "name": "DUF899_thioredox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010297": {"description": "Protein of unknown function DUF900, hydrolase-like", "go_ids": [], "go_terms": [], "name": "DUF900_hydrolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010298": {"description": "Ribosome-associated endoribonuclease 1", "go_ids": [], "go_terms": [], "name": "Rae1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010300": {"description": "Cysteine dioxygenase type I", "go_ids": ["GO:0005506", "GO:0016702"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016702:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen:F"], "name": "CDO_1", "pathway_ids": ["PWY-5331", "R-HSA-1614558", "R-MMU-1614558", "R-CEL-1614558", "R-RNO-1614558"], "pathways": ["PWY-5331:t:taurine biosynthesis I", "R-HSA-1614558:r:Degradation of cysteine and homocysteine", "R-MMU-1614558:r:Degradation of cysteine and homocysteine", "R-CEL-1614558:r:Degradation of cysteine and homocysteine", "R-RNO-1614558:r:Degradation of cysteine and homocysteine"], "type": "Family"}, "IPR010301": {"description": "Ribosomal RNA processing protein 1", "go_ids": ["GO:0006364", "GO:0030688"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0030688:preribosome, small subunit precursor:C"], "name": "RRP1", "pathway_ids": ["R-HSA-6791226"], "pathways": ["R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR010302": {"description": "UL27-like protein, herpesvirus", "go_ids": [], "go_terms": [], "name": "UL27-like_protein_herpesevirus", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR010303": {"description": "CREB-binding protein/p300, atypical RING domain", "go_ids": [], "go_terms": [], "name": "RING_CBP-p300", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-MMU-8941858", "R-RNO-933541", "R-HSA-8936459", "R-CEL-9701898", "R-RNO-9018519", "R-HSA-9818030", "R-CEL-9617629", "R-HSA-9616222", "R-HSA-9701898", "R-HSA-9614657", "R-HSA-2122947", "R-MMU-6804760", "R-HSA-9931521", "R-HSA-6804760", "R-RNO-9759194", "R-MMU-3371568", "R-CEL-8939246", "R-MMU-350054", "R-HSA-6804114", "R-MMU-6804758", "R-HSA-9793380", "R-RNO-9841922", "R-RNO-5621575", "R-HSA-2644606", "R-HSA-9031628", "R-HSA-9768919", "R-HSA-9833109", "R-CEL-8951936", "R-HSA-8941856", "R-HSA-9705671", "R-CEL-8936459", "R-MMU-2122947", "R-HSA-9735871", "R-CEL-3899300", "R-MMU-9759194", "R-MMU-9029569", "R-HSA-3371568", "R-HSA-9818028", "R-HSA-9617629", "R-RNO-400206", "R-MMU-8951936", "R-HSA-9839394", "R-MMU-3899300", "R-RNO-9856649", "R-HSA-210744", "R-HSA-156711", "R-HSA-381340", "R-MMU-8866907", "R-MMU-9701898", "R-HSA-9707616", "R-HSA-6811555", "R-HSA-350054", "R-HSA-201722", "R-HSA-933541", "R-HSA-9909649", "R-RNO-8941856", "R-RNO-8866907", "R-CEL-9018519", "R-HSA-3214847", "R-HSA-9856649", "R-RNO-9617629", "R-HSA-2426168", "R-MMU-9707564", "R-MMU-9856649", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-1234158", "R-MMU-5689901", "R-MMU-201722", "R-MMU-8939246", "R-HSA-9818749", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-1234158", "R-RNO-350054", "R-HSA-9933387", "R-HSA-9707564", "R-CEL-9856649", "R-HSA-9018519", "R-HSA-8951936", "R-RNO-3134973", "R-MMU-8936459", "R-MMU-5250924", "R-MMU-5621575", "R-HSA-8941858", "R-MMU-3134973", "R-CEL-9759194", "R-MMU-9018519", "R-HSA-9013695", "R-HSA-8939243", "R-HSA-9818026", "R-HSA-400206", "R-HSA-3134973", "R-MMU-400206", "R-HSA-5617472", "R-HSA-9818027", "R-HSA-5689901", "R-HSA-9819196", "R-MMU-933541", "R-RNO-201722", "R-HSA-9818035", "R-CEL-201722", "R-MMU-9617629", "R-RNO-8939246", "R-HSA-1912408", "R-HSA-6804758", "R-RNO-3371568", "R-HSA-918233", "R-HSA-5621575", "R-HSA-9759194", "R-HSA-9029569", "R-HSA-2173796", "R-HSA-9931509", "R-CEL-1234158", "R-HSA-8866907", "R-HSA-9013508", "R-HSA-2894862", "R-RNO-9707564", "R-MMU-8939243", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-6803204", "R-HSA-9818032", "R-MMU-8941856", "R-HSA-5250924", "R-MMU-6811555", "R-RNO-1234158", "R-HSA-3899300", "R-HSA-2197563", "R-HSA-8939246", "R-CEL-8939243"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-CEL-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-3371568:r:Attenuation phase", "R-CEL-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-3371568:r:Attenuation phase", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-9839394:r:TGFBR3 expression", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9707616:r:Heme signaling", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-3371568:r:Attenuation phase", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR010304": {"description": "Survival motor neuron, Tudor domain", "go_ids": ["GO:0003723", "GO:0005634", "GO:0005737", "GO:0006397"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C", "GO:0006397:mRNA processing:P"], "name": "SMN_Tudor", "pathway_ids": ["R-BTA-191859", "R-HSA-72163", "R-DRE-72163", "R-RNO-191859", "R-HSA-191859", "R-HSA-9770562", "R-DRE-9770562", "R-MMU-9770562", "R-HSA-9754678", "R-XTR-9770562", "R-RNO-9770562", "R-MMU-72163", "R-RNO-72163", "R-XTR-72163", "R-HSA-9918481", "R-MMU-191859", "R-DRE-191859"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-RNO-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DRE-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-XTR-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-191859:r:snRNP Assembly", "R-DRE-191859:r:snRNP Assembly"], "type": "Domain"}, "IPR010305": {"description": "Lipoprotein YgdI/YgdR-like", "go_ids": [], "go_terms": [], "name": "YgdI/YgdR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010306": {"description": "Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase", "go_ids": ["GO:0019700", "GO:0016829", "GO:0051539"], "go_terms": ["GO:0019700:organic phosphonate catabolic process:P", "GO:0016829:lyase activity:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "PhnJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010308": {"description": "TRP, C-terminal", "go_ids": [], "go_terms": [], "name": "TRP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010309": {"description": "E3 ubiquitin ligase, domain of unknown function DUF908", "go_ids": [], "go_terms": [], "name": "E3_Ub_ligase_DUF908", "pathway_ids": ["PWY-7511", "R-HSA-6798695", "R-SPO-6798695", "R-MMU-983168", "R-SPO-983168", "R-SCE-6798695", "R-MMU-6798695", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-RNO-6798695"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR010310": {"description": "Type VII secretion system ESAT-6-like", "go_ids": [], "go_terms": [], "name": "T7SS_ESAT-6-like", "pathway_ids": ["R-HSA-9636667", "R-HSA-9636383", "R-HSA-9635644", "R-HSA-9637628"], "pathways": ["R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-9635644:r:Inhibition of membrane repair", "R-HSA-9637628:r:Modulation by Mtb of host immune system"], "type": "Family"}, "IPR010311": {"description": "Reovirus core-spike lambda-2", "go_ids": ["GO:0004482", "GO:0004484", "GO:0005524", "GO:0006370", "GO:0019028"], "go_terms": ["GO:0004482:mRNA 5'-cap (guanine-N7-)-methyltransferase activity:F", "GO:0004484:mRNA guanylyltransferase activity:F", "GO:0005524:ATP binding:F", "GO:0006370:7-methylguanosine mRNA capping:P", "GO:0019028:viral capsid:C"], "name": "Reovirus_L2", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Family"}, "IPR010312": {"description": "Global transcriptional regulator CodY, N-terminal", "go_ids": ["GO:0003677", "GO:0005525"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005525:GTP binding:F"], "name": "Transc_reg_CodY_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010313": {"description": "Glycine N-acyltransferase", "go_ids": ["GO:0005739", "GO:0047961"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0047961:glycine N-acyltransferase activity:F"], "name": "Glycine_N-acyltransferase", "pathway_ids": ["R-MMU-177135", "R-HSA-177128", "R-RNO-177135", "R-HSA-9749641", "R-MMU-177128", "R-RNO-9749641", "R-MMU-9749641", "R-HSA-177135", "R-RNO-177128"], "pathways": ["R-MMU-177135:r:Conjugation of benzoate with glycine", "R-HSA-177128:r:Conjugation of salicylate with glycine", "R-RNO-177135:r:Conjugation of benzoate with glycine", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-177128:r:Conjugation of salicylate with glycine", "R-RNO-9749641:r:Aspirin ADME", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-177135:r:Conjugation of benzoate with glycine", "R-RNO-177128:r:Conjugation of salicylate with glycine"], "type": "Family"}, "IPR010314": {"description": "E3 ubiquitin ligase, domain of unknown function DUF913", "go_ids": [], "go_terms": [], "name": "E3_Ub_ligase_DUF913", "pathway_ids": ["PWY-7511", "R-HSA-6798695", "R-SPO-6798695", "R-MMU-983168", "R-SPO-983168", "R-SCE-6798695", "R-MMU-6798695", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-RNO-6798695"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR010315": {"description": "Protein of unknown function DUF915, hydrolase-like", "go_ids": [], "go_terms": [], "name": "DUF915_hydro-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010316": {"description": "DNA-3-methyladenine glycosylase AlkA, N-terminal", "go_ids": [], "go_terms": [], "name": "AlkA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010317": {"description": "WxL Interacting Protein, peptidoglycan binding domain", "go_ids": [], "go_terms": [], "name": "WxLIP_PGBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010318": {"description": "S-Me-THD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "S-Me-THD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010319": {"description": "Transglutaminase-like cysteine peptidase, predicted", "go_ids": [], "go_terms": [], "name": "Transglutaminase-like_Cys_pept", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010321": {"description": "Protein of unknown function DUF922", "go_ids": [], "go_terms": [], "name": "DUF922", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010323": {"description": "Protein of unknown function DUF924", "go_ids": [], "go_terms": [], "name": "DUF924", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010324": {"description": "Dam-replacing", "go_ids": [], "go_terms": [], "name": "DRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010325": {"description": "Rhamnogalacturonate lyase", "go_ids": [], "go_terms": [], "name": "Rhamnogal_lyase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010326": {"description": "Exocyst complex component EXOC3/Sec6", "go_ids": ["GO:0000145", "GO:0006887"], "go_terms": ["GO:0000145:exocyst:C", "GO:0006887:exocytosis:P"], "name": "EXOC3/Sec6", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-BTA-5620916", "R-RNO-5620916", "R-HSA-1445148", "R-MMU-264876", "R-HSA-264876", "R-CEL-5620916", "R-BTA-264876", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-264876:r:Insulin processing", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-264876:r:Insulin processing", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Family"}, "IPR010327": {"description": "FldB/FldC dehydratase alpha/beta subunit", "go_ids": [], "go_terms": [], "name": "FldB/FldC_alpha/beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010328": {"description": "Protein of unknown function DUF928", "go_ids": [], "go_terms": [], "name": "DUF928", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010329": {"description": "3-hydroxyanthranilic acid dioxygenase", "go_ids": ["GO:0000334", "GO:0005506"], "go_terms": ["GO:0000334:3-hydroxyanthranilate 3,4-dioxygenase activity:F", "GO:0005506:iron ion binding:F"], "name": "3hydroanth_dOase", "pathway_ids": ["PWY-6505", "PWY-6309", "PWY-5647", "PWY-5651", "R-HSA-71240", "R-RNO-71240", "R-DDI-71240", "R-CEL-71240", "R-DRE-71240", "R-SCE-71240", "R-MMU-71240"], "pathways": ["PWY-6505:t:L-tryptophan degradation XII (Geobacillus)", "PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-5647:t:2-nitrobenzoate degradation I", "PWY-5651:t:L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde", "R-HSA-71240:r:Tryptophan catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-DDI-71240:r:Tryptophan catabolism", "R-CEL-71240:r:Tryptophan catabolism", "R-DRE-71240:r:Tryptophan catabolism", "R-SCE-71240:r:Tryptophan catabolism", "R-MMU-71240:r:Tryptophan catabolism"], "type": "Family"}, "IPR010330": {"description": "Competence protein CoiA, nuclease-like domain", "go_ids": [], "go_terms": [], "name": "CoiA_nuc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010331": {"description": "Exopolysaccharide synthesis, ExoD", "go_ids": [], "go_terms": [], "name": "ExoD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010332": {"description": "Terminase, ATPase subunit, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ATPase_terminase-su_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010333": {"description": "Bacterial virulence", "go_ids": [], "go_terms": [], "name": "VirJ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010334": {"description": "mRNA-decapping enzyme subunit 1", "go_ids": ["GO:0043085", "GO:0000290", "GO:0008047"], "go_terms": ["GO:0043085:positive regulation of catalytic activity:P", "GO:0000290:deadenylation-dependent decapping of nuclear-transcribed mRNA:P", "GO:0008047:enzyme activator activity:F"], "name": "Dcp1", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-HSA-975957", "R-MMU-450513", "R-MMU-430039", "R-CEL-450385", "R-HSA-450513", "R-SCE-450513", "R-MMU-975957", "R-SCE-430039", "R-CEL-430039", "R-CEL-450513", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Family"}, "IPR010335": {"description": "Mesothelin", "go_ids": [], "go_terms": [], "name": "Mesothelin", "pathway_ids": ["R-RNO-381426", "R-MMU-163125", "R-RNO-8957275", "R-MMU-381426", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-163125", "R-HSA-163125"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR010336": {"description": "Baculoviridae ME53", "go_ids": ["GO:0003677", "GO:0008270"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008270:zinc ion binding:F"], "name": "Baculo_ME53", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010339": {"description": "TIP49, P-loop domain", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "TIP49_P-loop", "pathway_ids": ["R-DRE-5689880", "R-HSA-606279", "R-HSA-5689880", "R-RNO-606279", "R-DRE-201722", "R-MMU-606279", "R-CEL-201722", "R-DRE-5696394", "R-DME-5696394", "R-DME-201722", "R-RNO-5696394", "R-RNO-5689880", "R-HSA-171319", "R-CEL-5689880", "R-MMU-5689880", "R-RNO-5689603", "R-DRE-5689603", "R-HSA-201722", "R-DME-5689603", "R-HSA-5696394", "R-MMU-5696394", "R-MMU-5689603", "R-HSA-3214847", "R-HSA-5689603", "R-DME-5689880"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-5689603:r:UCH proteinases", "R-DRE-5689603:r:UCH proteinases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-5689603:r:UCH proteinases", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH proteinases", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-DME-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR010340": {"description": "Herpesvirus UL11/UL32", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Herpes_UL11/UL32", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR010341": {"description": "Protein CORTICAL MICROTUBULE DISORDERING", "go_ids": [], "go_terms": [], "name": "CORD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010342": {"description": "Protein of unknown function DUF938", "go_ids": [], "go_terms": [], "name": "DUF938", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010343": {"description": "Aromatic acid exporter family member 1", "go_ids": [], "go_terms": [], "name": "ArAE_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010344": {"description": "Exopolysaccharide biosynthesis protein YbjH", "go_ids": [], "go_terms": [], "name": "YbjH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010345": {"description": "Interleukin-17 family", "go_ids": ["GO:0005125", "GO:0005576"], "go_terms": ["GO:0005125:cytokine activity:F", "GO:0005576:extracellular region:C"], "name": "IL-17_fam", "pathway_ids": ["R-HSA-448424", "R-HSA-9705671", "R-HSA-6785807"], "pathways": ["R-HSA-448424:r:Interleukin-17 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling"], "type": "Family"}, "IPR010346": {"description": "Spanin, outer membrane subunit", "go_ids": ["GO:0044659"], "go_terms": ["GO:0044659:viral release from host cell by cytolysis:P"], "name": "O-spanin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010347": {"description": "Tyrosyl-DNA phosphodiesterase I", "go_ids": ["GO:0005634", "GO:0006281", "GO:0008081"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006281:DNA repair:P", "GO:0008081:phosphoric diester hydrolase activity:F"], "name": "Tdp1", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978", "R-RNO-5693571", "R-MMU-5693571", "R-HSA-5693571"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Family"}, "IPR010349": {"description": "L-asparaginase II", "go_ids": [], "go_terms": [], "name": "Asparaginase_II", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010350": {"description": "Thioredoxin-like ferredoxin, bacteria", "go_ids": [], "go_terms": [], "name": "Aim32/Apd1-like_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010351": {"description": "Protein of unknown function DUF943", "go_ids": [], "go_terms": [], "name": "DUF943", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010352": {"description": "Protein of unknown function DUF945", "go_ids": [], "go_terms": [], "name": "DUF945", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010353": {"description": "Phenol 2-monooxygenase, auxiliary component DmpK", "go_ids": [], "go_terms": [], "name": "DmpK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010354": {"description": "Oleate hydratase", "go_ids": ["GO:0006631", "GO:0050151", "GO:0071949"], "go_terms": ["GO:0006631:fatty acid metabolic process:P", "GO:0050151:oleate hydratase activity:F", "GO:0071949:FAD binding:F"], "name": "Oleate_hydratase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010357": {"description": "Thioredoxin domain-containing protein 17-like domain", "go_ids": [], "go_terms": [], "name": "TXNDC17_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010358": {"description": "BRCA1-A complex subunit BRE", "go_ids": ["GO:0070531", "GO:0070552"], "go_terms": ["GO:0070531:BRCA1-A complex:C", "GO:0070552:BRISC complex:C"], "name": "BRE", "pathway_ids": ["R-HSA-5689901", "R-DRE-5693607", "R-BTA-69473", "R-HSA-69473", "R-RNO-5693565", "R-MMU-5689901", "R-RNO-5693607", "R-BTA-5693565", "R-HSA-5693565", "R-RNO-5689901", "R-RNO-5693571", "R-RNO-69473", "R-XTR-5689901", "R-MMU-5693565", "R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-BTA-5693607", "R-BTA-5693571", "R-DRE-5693565", "R-MMU-5693571", "R-BTA-5689901", "R-MMU-5693607", "R-DRE-5689901"], "pathways": ["R-HSA-5689901:r:Metalloprotease DUBs", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5689901:r:Metalloprotease DUBs", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-XTR-5689901:r:Metalloprotease DUBs", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-5689901:r:Metalloprotease DUBs", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5689901:r:Metalloprotease DUBs"], "type": "Family"}, "IPR010359": {"description": "IrrE N-terminal-like domain", "go_ids": [], "go_terms": [], "name": "IrrE_HExxH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010360": {"description": "Protein of unknown function DUF956", "go_ids": [], "go_terms": [], "name": "DUF956", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010363": {"description": "Domain of unknown function DUF959, collagen XVIII, N-terminal", "go_ids": [], "go_terms": [], "name": "DUF959_COL18_N", "pathway_ids": ["R-HSA-1650814", "R-HSA-2022090", "R-HSA-216083", "R-MMU-1650814", "R-MMU-1592389", "R-HSA-3000157", "R-HSA-8948216", "R-MMU-8948216", "R-MMU-216083", "R-HSA-1592389", "R-MMU-1442490", "R-HSA-1442490", "R-MMU-2022090"], "pathways": ["R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-3000157:r:Laminin interactions", "R-HSA-8948216:r:Collagen chain trimerization", "R-MMU-8948216:r:Collagen chain trimerization", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1442490:r:Collagen degradation", "R-HSA-1442490:r:Collagen degradation", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures"], "type": "Domain"}, "IPR010364": {"description": "Uncharacterised protein family, inner membrane CreD", "go_ids": [], "go_terms": [], "name": "Uncharacterised_IM_CreD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010365": {"description": "Protein of unknown function DUF961", "go_ids": [], "go_terms": [], "name": "DUF961", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010366": {"description": "Arginine ADP-riboxanase OspC1-4", "go_ids": [], "go_terms": [], "name": "OspC1-4", "pathway_ids": ["PWY-8337", "PWY-8106", "R-HSA-9948001", "R-HSA-9956593"], "pathways": ["PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense"], "type": "Family"}, "IPR010367": {"description": "Poxvirus G3", "go_ids": [], "go_terms": [], "name": "Poxvirus_G3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010368": {"description": "Control of competence regulator ComK, YlbF/YmcA", "go_ids": [], "go_terms": [], "name": "Com_YlbF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010369": {"description": "Protein SOSEKI", "go_ids": [], "go_terms": [], "name": "SOK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010371": {"description": "YBR137W-like", "go_ids": [], "go_terms": [], "name": "YBR137W-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010372": {"description": "DNA polymerase III delta, N-terminal", "go_ids": ["GO:0003677", "GO:0003887", "GO:0006260", "GO:0009360"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P", "GO:0009360:DNA polymerase III complex:C"], "name": "DNA_pol3_delta_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010373": {"description": "Domain of unknown function DUF968", "go_ids": [], "go_terms": [], "name": "DUF968", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010374": {"description": "Protein of unknown function DUF969", "go_ids": [], "go_terms": [], "name": "DUF969", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010375": {"description": "Cyclic-di-AMP receptor", "go_ids": [], "go_terms": [], "name": "CdAMP_rec", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010376": {"description": "Gamma-butyrobetaine hydroxylase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "GBBH-like_N", "pathway_ids": ["R-RNO-71262", "R-MMU-71262", "R-GGA-71262", "R-HSA-71262", "R-BTA-71262"], "pathways": ["R-RNO-71262:r:Carnitine synthesis", "R-MMU-71262:r:Carnitine synthesis", "R-GGA-71262:r:Carnitine synthesis", "R-HSA-71262:r:Carnitine synthesis", "R-BTA-71262:r:Carnitine synthesis"], "type": "Domain"}, "IPR010377": {"description": "Replication initiation control protein YabA", "go_ids": ["GO:0006260"], "go_terms": ["GO:0006260:DNA replication:P"], "name": "YabA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010378": {"description": "Trafficking protein particle complex subunit 13", "go_ids": [], "go_terms": [], "name": "TRAPPC13", "pathway_ids": ["R-RNO-8876198", "R-HSA-8876198", "R-MMU-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-DME-8876198", "R-DRE-8876198"], "pathways": ["R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR010379": {"description": "Septation ring formation regulator EzrA", "go_ids": ["GO:0000921", "GO:0005940", "GO:0016020"], "go_terms": ["GO:0000921:septin ring assembly:P", "GO:0005940:septin ring:C", "GO:0016020:membrane:C"], "name": "EzrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010380": {"description": "Protein of unknown function DUF975", "go_ids": [], "go_terms": [], "name": "DUF975", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010381": {"description": "Putative pyroglutamyl peptidase 1", "go_ids": [], "go_terms": [], "name": "PgaPase_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010382": {"description": "Protein of unknown function DUF977", "go_ids": [], "go_terms": [], "name": "DUF977", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010383": {"description": "Glycosyl hydrolase 94, supersandwich domain", "go_ids": [], "go_terms": [], "name": "Glyco_hydrolase_94_b-supersand", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010384": {"description": "MtfA family", "go_ids": [], "go_terms": [], "name": "MtfA_fam", "pathway_ids": ["PWY-7694", "PWY-6423", "PWY-7954"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-6423:t:hemoglobin degradation", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis"], "type": "Family"}, "IPR010385": {"description": "Protein of unknown function DUF982", "go_ids": [], "go_terms": [], "name": "DUF982", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010386": {"description": "tRNA-hydroxylase MiaE", "go_ids": ["GO:0006400", "GO:0045301"], "go_terms": ["GO:0006400:tRNA modification:P", "GO:0045301:tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase activity:F"], "name": "tRNA-Hydrxlase_MiaE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010387": {"description": "Queuosine precursor transporter QueT", "go_ids": [], "go_terms": [], "name": "QueT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010388": {"description": "Anaerobic cobalt chelatase", "go_ids": ["GO:0016852"], "go_terms": ["GO:0016852:sirohydrochlorin cobaltochelatase activity:F"], "name": "Anaerobic_Co-chelatase", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Family"}, "IPR010389": {"description": "Urate oxidase N-terminal", "go_ids": [], "go_terms": [], "name": "Urate_ox_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010390": {"description": "ABC-2 transporter-like", "go_ids": [], "go_terms": [], "name": "ABC-2_transporter-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010391": {"description": "DNA damage-inducible protein DinI-like", "go_ids": [], "go_terms": [], "name": "DNA_damage-inducible_DinI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010392": {"description": "Satellite virus coat", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Satellite_virus_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010393": {"description": "Protein of unknown function DUF991, YecM-like", "go_ids": [], "go_terms": [], "name": "DUF991_YecM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010394": {"description": "5-nucleotidase", "go_ids": ["GO:0000166", "GO:0000287", "GO:0005737", "GO:0008253", "GO:0009117"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0000287:magnesium ion binding:F", "GO:0005737:cytoplasm:C", "GO:0008253:5'-nucleotidase activity:F", "GO:0009117:nucleotide metabolic process:P"], "name": "5-nucleotidase", "pathway_ids": ["PWY-7821", "PWY-7185", "PWY-5381", "PWY-6596", "PWY-5695", "PWY-6607", "PWY-6608", "PWY-6606", "R-MMU-74259", "R-HSA-74259", "R-MMU-73621", "R-HSA-73621"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-5381:t:NAD salvage (plants)", "PWY-6596:t:adenosine nucleotides degradation I", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II", "R-MMU-74259:r:Purine catabolism", "R-HSA-74259:r:Purine catabolism", "R-MMU-73621:r:Pyrimidine catabolism", "R-HSA-73621:r:Pyrimidine catabolism"], "type": "Family"}, "IPR010396": {"description": "Poxvirus A4L", "go_ids": [], "go_terms": [], "name": "Poxvirus_A4L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010397": {"description": "Protein of unknown function DUF996", "go_ids": [], "go_terms": [], "name": "DUF996", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010398": {"description": "Protein of unknown function DUF997", "go_ids": [], "go_terms": [], "name": "DUF997", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010399": {"description": "Tify domain", "go_ids": [], "go_terms": [], "name": "Tify_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010400": {"description": "PITH domain", "go_ids": [], "go_terms": [], "name": "PITH_dom", "pathway_ids": ["R-HSA-9013420", "R-HSA-9013422", "R-HSA-9013418", "R-HSA-9696270", "R-RNO-9013422", "R-RNO-9696270", "R-MMU-9013424", "R-HSA-9013424", "R-RNO-9696273", "R-RNO-9013420", "R-HSA-9696264", "R-MMU-9013422", "R-MMU-9013420", "R-RNO-9013424", "R-SPO-9696273", "R-SPO-9013424", "R-RNO-9696264", "R-SPO-9013420", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9696273", "R-RNO-9013418", "R-MMU-9013418"], "pathways": ["R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-SPO-9013424:r:RHOV GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle"], "type": "Domain"}, "IPR010401": {"description": "Glycogen debranching enzyme", "go_ids": ["GO:0004135", "GO:0005980", "GO:0004134"], "go_terms": ["GO:0004135:amylo-alpha-1,6-glucosidase activity:F", "GO:0005980:glycogen catabolic process:P", "GO:0004134:4-alpha-glucanotransferase activity:F"], "name": "AGL/Gdb1", "pathway_ids": ["PWY-7238", "PWY-6724", "PWY-5941", "PWY-6737", "R-SCE-70221", "R-HSA-6798695", "R-HSA-70221", "R-SCE-6798695"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6724:t:starch degradation II", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-SCE-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR010402": {"description": "CCT domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "CCT_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010404": {"description": "Chromophore lyase CpcT/CpeT", "go_ids": ["GO:0017009", "GO:0016829"], "go_terms": ["GO:0017009:protein-phycocyanobilin linkage:P", "GO:0016829:lyase activity:F"], "name": "CpcT/CpeT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010405": {"description": "Cofactor of BRCA1", "go_ids": ["GO:0005634", "GO:0045892"], "go_terms": ["GO:0005634:nucleus:C", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "COBRA1", "pathway_ids": ["R-DME-113418", "R-MMU-6796648", "R-HSA-9603505", "R-HSA-167238", "R-DME-674695", "R-MMU-113418", "R-HSA-167243", "R-DME-6796648", "R-HSA-167242", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-75955", "R-HSA-167152", "R-HSA-113418", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-DME-113418:r:Formation of the Early Elongation Complex", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Family"}, "IPR010406": {"description": "Protein of unknown function DUF1003", "go_ids": [], "go_terms": [], "name": "DUF1003", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010407": {"description": "Signaling lymphocytic activation molecule, N-terminal", "go_ids": ["GO:0038023", "GO:0009986", "GO:0016020", "GO:0046649"], "go_terms": ["GO:0038023:signaling receptor activity:F", "GO:0009986:cell surface:C", "GO:0016020:membrane:C", "GO:0046649:lymphocyte activation:P"], "name": "Sig_lymph_act_molc_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010408": {"description": "Haemagglutinin-esterase glycoprotein, infectious salmon anaemia virus-type", "go_ids": [], "go_terms": [], "name": "Hemagglutn-estrase_ISAV-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010409": {"description": "GAGA-binding transcriptional activator", "go_ids": [], "go_terms": [], "name": "GAGA-bd_tscrpt_act", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010410": {"description": "Protein of unknown function DUF1005", "go_ids": [], "go_terms": [], "name": "DUF1005", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010411": {"description": "Phage tail assembly chaperone Gp13-like", "go_ids": [], "go_terms": [], "name": "TAC_Gp13-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010412": {"description": "Protein of unknown function DUF1007", "go_ids": [], "go_terms": [], "name": "DUF1007", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010413": {"description": "Intracellular heme transport protein HutX-like", "go_ids": [], "go_terms": [], "name": "HutX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010414": {"description": "Protein FRG1", "go_ids": [], "go_terms": [], "name": "FRG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010415": {"description": "LpxI, C-terminal", "go_ids": [], "go_terms": [], "name": "LpxI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010416": {"description": "Protein of unknown function DUF1010", "go_ids": [], "go_terms": [], "name": "DUF1010", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010417": {"description": "Embryo-specific ATS3", "go_ids": [], "go_terms": [], "name": "Embryo-specific_ATS3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010418": {"description": "ECSIT", "go_ids": [], "go_terms": [], "name": "ECSIT", "pathway_ids": ["R-MMU-975871", "R-HSA-975871", "R-HSA-166058", "R-HSA-975138", "R-MMU-166058", "R-MMU-6799198", "R-RNO-166058", "R-HSA-6799198", "R-DME-6799198", "R-XTR-6799198", "R-BTA-975871", "R-RNO-6799198", "R-RNO-975871", "R-BTA-166058", "R-XTR-975138", "R-DRE-6799198", "R-MMU-975138", "R-RNO-975138", "R-BTA-6799198", "R-BTA-975138", "R-XTR-166058", "R-XTR-975871"], "pathways": ["R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-6799198:r:Complex I biogenesis", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-XTR-6799198:r:Complex I biogenesis", "R-BTA-975871:r:MyD88 cascade initiated on plasma membrane", "R-RNO-6799198:r:Complex I biogenesis", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-BTA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-XTR-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-XTR-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-XTR-975871:r:MyD88 cascade initiated on plasma membrane"], "type": "Family"}, "IPR010419": {"description": "Carbon monoxide dehydrogenase subunit G", "go_ids": [], "go_terms": [], "name": "CO_DH_gsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010420": {"description": "CASTOR/POLLUX/SYM8 ion channel, conserved domain", "go_ids": [], "go_terms": [], "name": "CASTOR/POLLUX/SYM8_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010421": {"description": "Transcriptional cell cycle regulator TrcR", "go_ids": [], "go_terms": [], "name": "TrcR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010422": {"description": "Coiled-coil domain-containing protein 124/Oxs1", "go_ids": [], "go_terms": [], "name": "Ccdc124/Oxs1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010423": {"description": "Ookinete surface antigen, EGF domain", "go_ids": ["GO:0009986", "GO:0016020"], "go_terms": ["GO:0009986:cell surface:C", "GO:0016020:membrane:C"], "name": "Pvs25/Psv28_EGF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010424": {"description": "Acetate kinase EutQ", "go_ids": [], "go_terms": [], "name": "EutQ", "pathway_ids": ["PWY-8086", "PWY-8377", "PWY-5497", "PWY-8303", "PWY-8015", "PWY-5485", "PWY-5482"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-8015:t:glycine degradation (reductive Stickland reaction)", "PWY-5485:t:pyruvate fermentation to acetate IV", "PWY-5482:t:pyruvate fermentation to acetate II"], "type": "Family"}, "IPR010425": {"description": "Capsule biosynthesis GfcC-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Caps_synth_GfcC-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010426": {"description": "Trimethylamine methyltransferase", "go_ids": ["GO:0008168", "GO:0015948"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0015948:methanogenesis:P"], "name": "MTTB_MeTrfase", "pathway_ids": ["PWY-5250"], "pathways": ["PWY-5250:t:methanogenesis from trimethylamine"], "type": "Family"}, "IPR010427": {"description": "Domain of unknown function DUF1023", "go_ids": [], "go_terms": [], "name": "DUF1023", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010428": {"description": "Zincin-like metallopeptidase", "go_ids": [], "go_terms": [], "name": "Zincin_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010430": {"description": "Protein of unknown function DUF1028", "go_ids": [], "go_terms": [], "name": "DUF1028", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010431": {"description": "Fascin", "go_ids": ["GO:0051015", "GO:0007015"], "go_terms": ["GO:0051015:actin filament binding:F", "GO:0007015:actin filament organization:P"], "name": "Fascin", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361", "R-HSA-6785807"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling"], "type": "Family"}, "IPR010432": {"description": "RDD", "go_ids": [], "go_terms": [], "name": "RDD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010433": {"description": "Plant specific eukaryotic initiation factor 4B", "go_ids": ["GO:0003743"], "go_terms": ["GO:0003743:translation initiation factor activity:F"], "name": "EIF-4B_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010434": {"description": "Protein of unknown function DUF1033", "go_ids": [], "go_terms": [], "name": "DUF1033", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010435": {"description": "C5a peptidase/Subtilisin-like protease SBT2-like, Fn3-like domain", "go_ids": ["GO:0004252", "GO:0005618", "GO:0016020"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0005618:cell wall:C", "GO:0016020:membrane:C"], "name": "C5a/SBT2-like_Fn3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010436": {"description": "Herpesvirus UL84", "go_ids": [], "go_terms": [], "name": "Herpes_UL84", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR010437": {"description": "Type III secretion system SsaH/EsaH", "go_ids": [], "go_terms": [], "name": "T3SS_SsaH/EsaH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010438": {"description": "Bor", "go_ids": [], "go_terms": [], "name": "Lambda_Bor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010439": {"description": "MUN domain", "go_ids": [], "go_terms": [], "name": "MUN_dom", "pathway_ids": ["R-HSA-6798695", "R-HSA-181430", "R-MMU-212676", "R-CEL-181430", "R-RNO-210500", "R-RNO-181430", "R-MMU-181430", "R-CEL-210500", "R-MMU-210500", "R-HSA-264642", "R-MMU-181429", "R-CEL-212676", "R-MMU-264642", "R-HSA-181429", "R-RNO-212676", "R-RNO-264642", "R-MMU-6798695", "R-CEL-181429", "R-RNO-181429", "R-CEL-264642", "R-HSA-212676", "R-HSA-210500", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR010441": {"description": "CH-like domain in sperm protein", "go_ids": [], "go_terms": [], "name": "CH_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010442": {"description": "PET domain", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "PET_domain", "pathway_ids": ["R-XTR-4608870", "R-RNO-4608870", "R-DME-350369", "R-DME-350411", "R-HSA-4608870", "R-HSA-5683826", "R-BTA-5683826", "R-DME-350368", "R-DME-350480", "R-DME-4608870", "R-SSC-5683826", "R-MMU-4608870", "R-DME-450728", "R-DME-350376", "R-MMU-5683826"], "pathways": ["R-XTR-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5683826:r:Surfactant metabolism", "R-BTA-5683826:r:Surfactant metabolism", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-5683826:r:Surfactant metabolism"], "type": "Domain"}, "IPR010443": {"description": "Restriction endonuclease, type II, Tsp45I", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_Tsp45I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010444": {"description": "Bacteriophage lambda Kil", "go_ids": [], "go_terms": [], "name": "Phage_lambda_Kil", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010445": {"description": "Lipopolysaccharide assembly protein A domain", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "LapA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010446": {"description": "Beta-1,4-N-acetylgalactosaminyltransferase", "go_ids": [], "go_terms": [], "name": "GalNAc_Trfase_b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010447": {"description": "Herpesvirus IR6", "go_ids": [], "go_terms": [], "name": "Herpes_IR6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010448": {"description": "Torsin", "go_ids": ["GO:0016887", "GO:0005524"], "go_terms": ["GO:0016887:ATP hydrolysis activity:F", "GO:0005524:ATP binding:F"], "name": "Torsin", "pathway_ids": ["R-DME-8856825", "R-HSA-114608", "R-DRE-114608", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-DME-114608", "R-CEL-114608", "R-CEL-8856825", "R-XTR-114608", "R-MMU-114608"], "pathways": ["R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR010449": {"description": "NUMB domain", "go_ids": [], "go_terms": [], "name": "Numb_domain", "pathway_ids": ["R-HSA-5610780", "R-RNO-5632684", "R-MMU-5610780", "R-RNO-5610780", "R-MMU-437239", "R-MMU-5632684", "R-HSA-9725554", "R-RNO-437239", "R-HSA-2122948", "R-HSA-437239", "R-HSA-5632684"], "pathways": ["R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-5632684:r:Hedgehog 'on' state"], "type": "Domain"}, "IPR010450": {"description": "Neurexophilin", "go_ids": [], "go_terms": [], "name": "Nxph", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010451": {"description": "Acetoacetate decarboxylase", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "Acetoacetate_decarboxylase", "pathway_ids": ["PWY-6876", "PWY-6588"], "pathways": ["PWY-6876:t:isopropanol biosynthesis (engineered)", "PWY-6588:t:pyruvate fermentation to acetone"], "type": "Family"}, "IPR010452": {"description": "Isocitrate dehydrogenase kinasephosphatase", "go_ids": ["GO:0005737", "GO:0006006", "GO:0008772", "GO:0016791"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006006:glucose metabolic process:P", "GO:0008772:[isocitrate dehydrogenase (NADP+)] kinase activity:F", "GO:0016791:phosphatase activity:F"], "name": "Isocitrate_DH_AceK", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR010453": {"description": "RNA polymerase, arenaviral", "go_ids": ["GO:0003968", "GO:0019079"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0019079:viral genome replication:P"], "name": "RNA_pol_arenavir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010454": {"description": "Bacteriophage NinH", "go_ids": [], "go_terms": [], "name": "Phage_NinH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010455": {"description": "Antitermination protein Q", "go_ids": [], "go_terms": [], "name": "Phage_82_GpQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010457": {"description": "Immunoglobulin C2-set-like, ligand-binding", "go_ids": [], "go_terms": [], "name": "IgC2-like_lig-bd", "pathway_ids": ["R-RNO-112411", "R-HSA-449836", "R-HSA-9020591", "R-HSA-9942503", "R-HSA-1059683", "R-MMU-8984722", "R-MMU-112411", "R-HSA-112411", "R-RNO-1059683", "R-RNO-8984722", "R-MMU-9020956", "R-RNO-9020956", "R-HSA-6788467", "R-HSA-110056", "R-MMU-9020591", "R-MMU-1059683", "R-HSA-9705462", "R-RNO-110056", "R-HSA-9020956", "R-MMU-6788467", "R-HSA-9616222", "R-MMU-110056", "R-HSA-9674555", "R-RNO-6788467", "R-HSA-2586552", "R-HSA-8984722"], "pathways": ["R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-1059683:r:Interleukin-6 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-MMU-9020591:r:Interleukin-12 signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-8984722:r:Interleukin-35 Signalling"], "type": "Domain"}, "IPR010458": {"description": "Trichodiene synthase, ascomycetes", "go_ids": ["GO:0016106", "GO:0045482"], "go_terms": ["GO:0016106:sesquiterpenoid biosynthetic process:P", "GO:0045482:trichodiene synthase activity:F"], "name": "TRI5_ascomyc", "pathway_ids": ["PWY-7711"], "pathways": ["PWY-7711:t:calonectrin biosynthesis"], "type": "Family"}, "IPR010461": {"description": "Competence protein ComK", "go_ids": ["GO:0030420"], "go_terms": ["GO:0030420:establishment of competence for transformation:P"], "name": "ComK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010462": {"description": "Ectoine synthase", "go_ids": ["GO:0033990", "GO:0019491"], "go_terms": ["GO:0033990:ectoine synthase activity:F", "GO:0019491:ectoine biosynthetic process:P"], "name": "Ectoine_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010463": {"description": "Protein of unknown function DUF1057", "go_ids": [], "go_terms": [], "name": "DUF1057", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010465": {"description": "DRF autoregulatory", "go_ids": [], "go_terms": [], "name": "Drf_DAD", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-MMU-6785631", "R-HSA-6798695", "R-RNO-6798695", "R-RNO-6785631", "R-MMU-9013106", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-9013106", "R-MMU-9013404", "R-DME-9035034", "R-HSA-9035034", "R-DME-9013406", "R-RNO-9013404", "R-RNO-9013406", "R-RNO-9013106", "R-RNO-9013408", "R-DME-5663220", "R-MMU-9035034", "R-DME-9013149", "R-DME-8980692", "R-DME-6798695", "R-DME-6785631", "R-HSA-6785631", "R-RNO-5663220", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-8980692", "R-HSA-9854909", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9013026", "R-MMU-6798695", "R-HSA-5663220", "R-MMU-9013149", "R-DME-9013423", "R-MMU-5663220"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR010466": {"description": "Protein of unknown function DUF1058", "go_ids": [], "go_terms": [], "name": "DUF1058", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010468": {"description": "Hormone-sensitive lipase, N-terminal", "go_ids": ["GO:0008203", "GO:0016042", "GO:0016298"], "go_terms": ["GO:0008203:cholesterol metabolic process:P", "GO:0016042:lipid catabolic process:P", "GO:0016298:lipase activity:F"], "name": "HSL_N", "pathway_ids": ["PWY-7420", "R-HSA-163560", "R-HSA-9841922"], "pathways": ["PWY-7420:t:monoacylglycerol metabolism (yeast)", "R-HSA-163560:r:Triglyceride catabolism", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "type": "Domain"}, "IPR010470": {"description": "Beet necrotic yellow vein virus, movement protein TGB3", "go_ids": [], "go_terms": [], "name": "BNYVV_TGB3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010471": {"description": "Protein of unknown function DUF1068", "go_ids": [], "go_terms": [], "name": "DUF1068", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010472": {"description": "Formin, FH3 domain", "go_ids": ["GO:0003779", "GO:0016043"], "go_terms": ["GO:0003779:actin binding:F", "GO:0016043:cellular component organization:P"], "name": "FH3_dom", "pathway_ids": ["R-HSA-4086400", "R-HSA-6785631", "R-RNO-5663220", "R-RNO-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-HSA-8980692", "R-HSA-9854909", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9013026", "R-MMU-6798695", "R-HSA-5663220", "R-DRE-8980692", "R-HSA-9013406", "R-MMU-9013149", "R-BTA-9013106", "R-RNO-6798695", "R-RNO-9013026", "R-HSA-9013405", "R-MMU-6785631", "R-HSA-6798695", "R-HSA-9013409", "R-RNO-6785631", "R-MMU-9013106", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-BTA-5663220", "R-HSA-9013106", "R-MMU-9013404", "R-HSA-9013423", "R-DME-9035034", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013406", "R-RNO-9013404", "R-RNO-9013406", "R-RNO-9013106", "R-RNO-9013408", "R-DME-5663220", "R-DME-9013423", "R-DRE-5663220", "R-HSA-9013408", "R-MMU-5663220", "R-MMU-9035034", "R-DME-9013149", "R-DRE-9013106", "R-DME-8980692", "R-DME-6798695", "R-DME-6785631", "R-MMU-4086400"], "pathways": ["R-HSA-4086400:r:PCP/CE pathway", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-9013106:r:RHOC GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-4086400:r:PCP/CE pathway"], "type": "Domain"}, "IPR010473": {"description": "Formin, GTPase-binding domain", "go_ids": ["GO:0003779", "GO:0030036", "GO:0031267"], "go_terms": ["GO:0003779:actin binding:F", "GO:0030036:actin cytoskeleton organization:P", "GO:0031267:small GTPase binding:F"], "name": "GTPase-bd", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-DDI-354192", "R-MMU-6785631", "R-HSA-6798695", "R-HSA-9013409", "R-MMU-9013106", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9013404", "R-DME-9035034", "R-DDI-9013423", "R-RNO-9013404", "R-RNO-9013406", "R-RNO-9013408", "R-DME-5663220", "R-DRE-5663220", "R-HSA-9013408", "R-DDI-193648", "R-MMU-9035034", "R-DME-9013149", "R-DRE-9013106", "R-DME-8980692", "R-DME-6785631", "R-MMU-4086400", "R-DDI-5673001", "R-RNO-5663220", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013406", "R-HSA-9013026", "R-MMU-6798695", "R-DRE-8980692", "R-BTA-9013106", "R-MMU-5663220", "R-RNO-6798695", "R-RNO-6785631", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-8980692", "R-BTA-5663220", "R-HSA-9013106", "R-DDI-9013149", "R-HSA-9013423", "R-DDI-381676", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013406", "R-RNO-9013106", "R-DDI-171007", "R-DME-6798695", "R-HSA-4086400", "R-DDI-392517", "R-HSA-6785631", "R-DDI-1169092", "R-RNO-9013423", "R-DRE-9013148", "R-HSA-9854909", "R-MMU-9013026", "R-HSA-5663220", "R-HSA-9013406", "R-MMU-9013149", "R-DME-9013423"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DDI-354192:r:Integrin signaling", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-9013106:r:RHOC GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-4086400:r:PCP/CE pathway", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-8980692:r:RHOA GTPase cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-DDI-171007:r:p38MAPK events", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-4086400:r:PCP/CE pathway", "R-DDI-392517:r:Rap1 signalling", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-DDI-1169092:r:Activation of RAS in B cells", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR010474": {"description": "AP-3 complex subunit delta domain, metazoa", "go_ids": ["GO:0030123", "GO:0015031"], "go_terms": ["GO:0030123:AP-3 adaptor complex:C", "GO:0015031:protein transport:P"], "name": "AP3D_dom_metazoa", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010475": {"description": "Adipokinetic hormone/red pigment-concentrating hormone", "go_ids": ["GO:0005179"], "go_terms": ["GO:0005179:hormone activity:F"], "name": "AKH/RPCH_hormone", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010479": {"description": "BH3-interacting domain death agonist", "go_ids": ["GO:0005737", "GO:0043065"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0043065:positive regulation of apoptotic process:P"], "name": "BID", "pathway_ids": ["R-HSA-114294", "R-SSC-75108", "R-HSA-111447", "R-RNO-111452", "R-SSC-111447", "R-HSA-75108", "R-MMU-111452", "R-RNO-75108", "R-MMU-75108", "R-MMU-111453", "R-RNO-111453", "R-MMU-111447", "R-HSA-111452", "R-RNO-114294", "R-HSA-111453", "R-SSC-114294", "R-HSA-6803204", "R-MMU-114294", "R-SSC-111453", "R-SSC-111452"], "pathways": ["R-HSA-114294:r:Activation, translocation and oligomerization of BAX", "R-SSC-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-RNO-111452:r:Activation and oligomerization of BAK protein", "R-SSC-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-MMU-111452:r:Activation and oligomerization of BAK protein", "R-RNO-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-MMU-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-MMU-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-RNO-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-111452:r:Activation and oligomerization of BAK protein", "R-RNO-114294:r:Activation, translocation and oligomerization of BAX", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-SSC-114294:r:Activation, translocation and oligomerization of BAX", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-114294:r:Activation, translocation and oligomerization of BAX", "R-SSC-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-SSC-111452:r:Activation and oligomerization of BAK protein"], "type": "Family"}, "IPR010480": {"description": "Pepsin inhibitor-3-like repeated domain", "go_ids": [], "go_terms": [], "name": "Pepsin-I3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010481": {"description": "Cdc24/Scd1, N-terminal", "go_ids": [], "go_terms": [], "name": "Cdc24/Scd1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010482": {"description": "TECPR1-like, DysF domain", "go_ids": [], "go_terms": [], "name": "TECPR1-like_DysF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010483": {"description": "Alpha-2-macroglobulin RAP, C-terminal", "go_ids": ["GO:0005783", "GO:0008201", "GO:0050750"], "go_terms": ["GO:0005783:endoplasmic reticulum:C", "GO:0008201:heparin binding:F", "GO:0050750:low-density lipoprotein particle receptor binding:F"], "name": "Alpha_2_MRAP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010486": {"description": "HNS-dependent expression A/B", "go_ids": [], "go_terms": [], "name": "HNS-dep_expression_A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010487": {"description": "Neugrin/Rrg9", "go_ids": [], "go_terms": [], "name": "NGRN/Rrg9", "pathway_ids": ["R-HSA-9937008", "R-HSA-6793080"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Family"}, "IPR010488": {"description": "Zeta toxin domain", "go_ids": ["GO:0016301", "GO:0005524"], "go_terms": ["GO:0016301:kinase activity:F", "GO:0005524:ATP binding:F"], "name": "Zeta_toxin_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010489": {"description": "Effector protein NleG", "go_ids": ["GO:0004842", "GO:0044403"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F", "GO:0044403:biological process involved in symbiotic interaction:P"], "name": "Effector_NleG", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR010490": {"description": "Conserved oligomeric Golgi complex subunit 6", "go_ids": ["GO:0017119", "GO:0006891"], "go_terms": ["GO:0017119:COG complex:C", "GO:0006891:intra-Golgi vesicle-mediated transport:P"], "name": "COG6", "pathway_ids": ["R-RNO-6811440", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-RNO-6807878", "R-RNO-6811438", "R-HSA-6807878", "R-CEL-6807878", "R-CEL-6811438", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Family"}, "IPR010491": {"description": "PRP1 splicing factor, N-terminal", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "PRP1_N", "pathway_ids": ["R-HSA-72165", "R-HSA-72163", "R-MMU-72165", "R-BTA-72165", "R-HSA-9918481", "R-RNO-72165", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR010492": {"description": "GINS complex, subunit Psf3", "go_ids": [], "go_terms": [], "name": "GINS_Psf3", "pathway_ids": ["R-BTA-176974", "R-SPO-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974"], "pathways": ["R-BTA-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA"], "type": "Family"}, "IPR010493": {"description": "Serine acetyltransferase, N-terminal", "go_ids": ["GO:0019344", "GO:0005737", "GO:0009001"], "go_terms": ["GO:0019344:L-cysteine biosynthetic process:P", "GO:0005737:cytoplasm:C", "GO:0009001:L-serine O-acetyltransferase activity:F"], "name": "Ser_AcTrfase_N", "pathway_ids": ["PWY-7274", "PWY-7870", "PWY-6936", "PWY-8071"], "pathways": ["PWY-7274:t:D-cycloserine biosynthesis", "PWY-7870:t:L-cysteine biosynthesis VII (from S-sulfo-L-cysteine)", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-8071:t:N-3-oxalyl-L-2,3-diaminopropanoate biosynthesis"], "type": "Domain"}, "IPR010494": {"description": "Repeat of unknown function DUF1079", "go_ids": [], "go_terms": [], "name": "DUF1079", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010495": {"description": "Haem-binding HasA", "go_ids": [], "go_terms": [], "name": "HasA_haem-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010496": {"description": "3-keto-alpha-glucoside-1,2-lyase/3-keto-2-hydroxy-glucal hydratase domain", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "AL/BT2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010497": {"description": "Epoxide hydrolase, N-terminal", "go_ids": [], "go_terms": [], "name": "Epoxide_hydro_N", "pathway_ids": ["R-RNO-211945", "R-SSC-211945", "R-MMU-211945"], "pathways": ["R-RNO-211945:r:Phase I - Functionalization of compounds", "R-SSC-211945:r:Phase I - Functionalization of compounds", "R-MMU-211945:r:Phase I - Functionalization of compounds"], "type": "Domain"}, "IPR010498": {"description": "Fimbrial protein SefA", "go_ids": [], "go_terms": [], "name": "SefA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010499": {"description": "Bacterial transcription activator, effector binding", "go_ids": [], "go_terms": [], "name": "AraC_E-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010500": {"description": "Hepcidin", "go_ids": ["GO:0005576", "GO:0006879"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006879:intracellular iron ion homeostasis:P"], "name": "Hepcidin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010502": {"description": "Carbohydrate-binding domain, family 9", "go_ids": ["GO:0004553", "GO:0016052", "GO:0030246"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0016052:carbohydrate catabolic process:P", "GO:0030246:carbohydrate binding:F"], "name": "Carb-bd_dom_fam9", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010503": {"description": "Type II heat-labile enterotoxin, B subunit", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "LT-IIB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010504": {"description": "Arfaptin homology (AH) domain", "go_ids": ["GO:0019904"], "go_terms": ["GO:0019904:protein domain specific binding:F"], "name": "AH_dom", "pathway_ids": ["R-CEL-6811440", "R-RNO-6811440", "R-HSA-416993", "R-BTA-6811440", "R-HSA-6811440", "R-HSA-202733", "R-RNO-416993", "R-MMU-6811440", "R-MMU-416993"], "pathways": ["R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors"], "type": "Domain"}, "IPR010505": {"description": "Molybdenum cofactor biosynthesis protein A-like, twitch domain", "go_ids": ["GO:0006777", "GO:0051539"], "go_terms": ["GO:0006777:Mo-molybdopterin cofactor biosynthetic process:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "MoaA_twitch", "pathway_ids": ["PWY-6823", "R-DME-947581", "R-BTA-947581", "R-DDI-947581", "R-HSA-947581", "R-MMU-947581"], "pathways": ["PWY-6823:t:molybdopterin biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Domain"}, "IPR010506": {"description": "DMAP1-binding domain", "go_ids": [], "go_terms": [], "name": "DMAP1-bd", "pathway_ids": ["R-HSA-4655427", "R-RNO-4655427", "R-HSA-9725371", "R-HSA-212300", "R-RNO-212300", "R-MMU-4655427", "R-HSA-427413", "R-MMU-212300", "R-HSA-5334118", "R-HSA-9701898", "R-HSA-9710421"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-MMU-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-5334118:r:DNA methylation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9710421:r:Defective pyroptosis"], "type": "Domain"}, "IPR010507": {"description": "Zinc finger, MYM-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_MYM", "pathway_ids": ["R-DME-2559580", "R-HSA-9703465", "R-DME-8939243", "R-DME-4570464", "R-DME-3899300", "R-HSA-9764725", "R-HSA-5655302", "R-MMU-9764725", "R-DME-8943724", "R-DME-3108214", "R-HSA-1839117"], "pathways": ["R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR010508": {"description": "Neurobeachin-like, DUF1088", "go_ids": [], "go_terms": [], "name": "NBEA-like_DUF1088", "pathway_ids": ["R-HSA-9609736", "R-HSA-163615", "R-HSA-112314", "R-HSA-2122947"], "pathways": ["R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-163615:r:PKA activation", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Domain"}, "IPR010510": {"description": "FGF binding 1", "go_ids": [], "go_terms": [], "name": "FGF1-bd", "pathway_ids": ["R-BTA-190377", "R-HSA-190377", "R-MMU-190377", "R-RNO-190377", "R-GGA-190377"], "pathways": ["R-BTA-190377:r:FGFR2b ligand binding and activation", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-RNO-190377:r:FGFR2b ligand binding and activation", "R-GGA-190377:r:FGFR2b ligand binding and activation"], "type": "Family"}, "IPR010511": {"description": "Lytic murein transglycosylase D , lipid attachment domain", "go_ids": [], "go_terms": [], "name": "MltD_lipid-attach", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR010512": {"description": "Protein of unknown function DUF1091", "go_ids": [], "go_terms": [], "name": "DUF1091", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010513": {"description": "KEN domain", "go_ids": ["GO:0006397", "GO:0004540"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:0004540:RNA nuclease activity:F"], "name": "KEN_dom", "pathway_ids": ["R-DDI-381070", "R-HSA-381070", "R-HSA-8983711", "R-HSA-909733", "R-SCE-381070", "R-MMU-909733", "R-MMU-381070", "R-CEL-381070", "R-SPO-381070", "R-MMU-8983711"], "pathways": ["R-DDI-381070:r:IRE1alpha activates chaperones", "R-HSA-381070:r:IRE1alpha activates chaperones", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SCE-381070:r:IRE1alpha activates chaperones", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-381070:r:IRE1alpha activates chaperones", "R-CEL-381070:r:IRE1alpha activates chaperones", "R-SPO-381070:r:IRE1alpha activates chaperones", "R-MMU-8983711:r:OAS antiviral response"], "type": "Domain"}, "IPR010514": {"description": "COX aromatic rich motif", "go_ids": ["GO:0016020", "GO:0022900", "GO:0009486"], "go_terms": ["GO:0016020:membrane:C", "GO:0022900:electron transport chain:P", "GO:0009486:cytochrome bo3 ubiquinol oxidase activity:F"], "name": "COX_ARM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010515": {"description": "Collagenase NC10/endostatin", "go_ids": [], "go_terms": [], "name": "Collagenase_NC10/endostatin", "pathway_ids": ["R-HSA-216083", "R-MMU-1592389", "R-HSA-3000157", "R-MMU-8948216", "R-HSA-1592389", "R-HSA-1650814", "R-MMU-2022090", "R-HSA-2022090", "R-MMU-1650814", "R-HSA-8948216", "R-MMU-216083", "R-MMU-1442490", "R-HSA-1442490"], "pathways": ["R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-8948216:r:Collagen chain trimerization", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-1442490:r:Collagen degradation", "R-HSA-1442490:r:Collagen degradation"], "type": "Domain"}, "IPR010516": {"description": "Sin3 associated polypeptide p18", "go_ids": [], "go_terms": [], "name": "SAP18", "pathway_ids": ["R-HSA-72163", "R-SPO-3214815", "R-MMU-72163", "R-HSA-427413", "R-MMU-3214815", "R-DME-72163", "R-HSA-3214815", "R-HSA-9679191", "R-CEL-72163", "R-DME-3214815"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-3214815:r:HDACs deacetylate histones", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DME-3214815:r:HDACs deacetylate histones"], "type": "Family"}, "IPR010517": {"description": "Phage tail tube protein, Siphoviridae", "go_ids": [], "go_terms": [], "name": "L_lac_phage_MSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010518": {"description": "Flagellar regulatory FleQ", "go_ids": [], "go_terms": [], "name": "FleQ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010519": {"description": "Female-specific protein transformer", "go_ids": ["GO:0006397", "GO:0046660"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:0046660:female sex differentiation:P"], "name": "Tra", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010520": {"description": "Esterase FrsA-like", "go_ids": [], "go_terms": [], "name": "FrsA-like", "pathway_ids": ["PWY-8454", "PWY-6857", "PWY-6303"], "pathways": ["PWY-8454:t:aspartame degradation", "PWY-6857:t:retinol biosynthesis", "PWY-6303:t:methyl indole-3-acetate interconversion"], "type": "Family"}, "IPR010521": {"description": "Fijivirus, VP7-1-like", "go_ids": [], "go_terms": [], "name": "Fijivirus_VP7-1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010522": {"description": "Replication protein C, bacterial", "go_ids": [], "go_terms": [], "name": "RepC_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010523": {"description": "Activator of aromatic catabolism", "go_ids": [], "go_terms": [], "name": "XylR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010524": {"description": "Signal transduction response regulator, propionate catabolism activator, N-terminal", "go_ids": ["GO:0000156", "GO:0000160", "GO:0003677", "GO:0005524"], "go_terms": ["GO:0000156:phosphorelay response regulator activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F"], "name": "Sig_transdc_resp-reg_PrpR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010525": {"description": "Auxin response factor domain", "go_ids": ["GO:0003677", "GO:0005634", "GO:0009725", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0009725:response to hormone:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "ARF_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010526": {"description": "Sodium ion transport-associated domain", "go_ids": ["GO:0001518", "GO:0005248", "GO:0006814"], "go_terms": ["GO:0001518:voltage-gated sodium channel complex:C", "GO:0005248:voltage-gated sodium channel activity:F", "GO:0006814:sodium ion transport:P"], "name": "Na_trans_assoc_dom", "pathway_ids": ["R-HSA-9717207", "R-HSA-445095", "R-HSA-5576892"], "pathways": ["R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-HSA-5576892:r:Phase 0 - rapid depolarisation"], "type": "Domain"}, "IPR010527": {"description": "Photosystem II PsbU, oxygen evolving complex", "go_ids": ["GO:0009654", "GO:0019898", "GO:0042549", "GO:0009523", "GO:0015979"], "go_terms": ["GO:0009654:photosystem II oxygen evolving complex:C", "GO:0019898:extrinsic component of membrane:C", "GO:0042549:photosystem II stabilization:P", "GO:0009523:photosystem II:C", "GO:0015979:photosynthesis:P"], "name": "PSII_PsbU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010530": {"description": "NADH-ubiquinone reductase complex 1 MLRQ subunit", "go_ids": [], "go_terms": [], "name": "B12D", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-MMU-9707564", "R-DRE-611105", "R-HSA-9707564", "R-MMU-5628897", "R-MMU-611105", "R-DRE-9864848", "R-DRE-5628897", "R-MMU-9864848", "R-DRE-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-BTA-5628897", "R-BTA-611105", "R-BTA-9707564"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DRE-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-DRE-9864848:r:Complex IV assembly", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9864848:r:Complex IV assembly", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR010531": {"description": "Zinc finger protein NOA36", "go_ids": ["GO:0005634", "GO:0008270"], "go_terms": ["GO:0005634:nucleus:C", "GO:0008270:zinc ion binding:F"], "name": "NOA36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010532": {"description": "Sulfocyanin", "go_ids": ["GO:0005507"], "go_terms": ["GO:0005507:copper ion binding:F"], "name": "SoxE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010533": {"description": "Vertebrate interleukin-3 regulated transcription factor", "go_ids": ["GO:0005634", "GO:0007623", "GO:0006351"], "go_terms": ["GO:0005634:nucleus:C", "GO:0007623:circadian rhythm:P", "GO:0006351:DNA-templated transcription:P"], "name": "Vert_IL3-reg_TF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010534": {"description": "Bacteriophage 933W, GpQ", "go_ids": ["GO:0003677", "GO:0060567"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0060567:negative regulation of termination of DNA-templated transcription:P"], "name": "Phage_933W_GpQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010535": {"description": "Protein of unknown function DUF1110", "go_ids": [], "go_terms": [], "name": "DUF1110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010536": {"description": "Repulsive guidance molecule, N-terminal", "go_ids": [], "go_terms": [], "name": "RGM_N", "pathway_ids": ["R-HSA-373752"], "pathways": ["R-HSA-373752:r:Netrin-1 signaling"], "type": "Domain"}, "IPR010537": {"description": "Avian adenovirus fibre, N-terminal", "go_ids": ["GO:0019062"], "go_terms": ["GO:0019062:virion attachment to host cell:P"], "name": "Avian_adenovirus_fibre_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010538": {"description": "Di-haem oxidoreductase, putative peroxidase", "go_ids": [], "go_terms": [], "name": "DHOR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010539": {"description": "Bax inhibitor 1 like", "go_ids": [], "go_terms": [], "name": "BaxI_1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010540": {"description": "Putative ABC-transporter type IV CmpB/TMEM229", "go_ids": [], "go_terms": [], "name": "CmpB_TMEM229", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010541": {"description": "Small nuclear ribonucleoprotein Prp3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Prp3_C", "pathway_ids": ["R-MMU-3065678", "R-HSA-72163", "R-MMU-72163"], "pathways": ["R-MMU-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR010542": {"description": "Vertebrate heat shock transcription factor, C-terminal domain", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Vert_HSTF_C", "pathway_ids": ["R-HSA-3371511", "R-HSA-9646399", "R-DME-3371453", "R-BTA-3371453", "R-BTA-3371568", "R-BTA-3371511", "R-HSA-9841251", "R-BTA-3371571", "R-MMU-3371571", "R-DME-3371511", "R-DME-3371568", "R-MMU-3371568", "R-DME-3371571", "R-MMU-9841251", "R-DME-9841251", "R-HSA-3371453", "R-MMU-3371511", "R-HSA-3371571", "R-BTA-9841251", "R-HSA-3371568", "R-MMU-3371453"], "pathways": ["R-HSA-3371511:r:HSF1 activation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371568:r:Attenuation phase", "R-BTA-3371511:r:HSF1 activation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-DME-3371511:r:HSF1 activation", "R-DME-3371568:r:Attenuation phase", "R-MMU-3371568:r:Attenuation phase", "R-DME-3371571:r:HSF1-dependent transactivation", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371511:r:HSF1 activation", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-3371568:r:Attenuation phase", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR010543": {"description": "Domain of unknown function DUF1117", "go_ids": [], "go_terms": [], "name": "DUF1117", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR010545": {"description": "Signal-peptide peptidase, presenilin aspartyl protease, archaea", "go_ids": [], "go_terms": [], "name": "SPP_arch", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010546": {"description": "Protein of unknown function DUF1120", "go_ids": [], "go_terms": [], "name": "DUF1120", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010547": {"description": "Plant specific mitochondrial import receptor subunit TOM20", "go_ids": ["GO:0005742", "GO:0045040"], "go_terms": ["GO:0005742:mitochondrial outer membrane translocase complex:C", "GO:0045040:protein insertion into mitochondrial outer membrane:P"], "name": "TOM20_imprt_rcpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010548": {"description": "BNIP3", "go_ids": ["GO:0005740", "GO:0016020", "GO:0043065"], "go_terms": ["GO:0005740:mitochondrial envelope:C", "GO:0016020:membrane:C", "GO:0043065:positive regulation of apoptotic process:P"], "name": "BNIP3", "pathway_ids": ["R-MMU-6803204", "R-HSA-6803204", "R-BTA-6803204"], "pathways": ["R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-BTA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "type": "Family"}, "IPR010549": {"description": "African swine fever virus, IAP-like p27, C-terminal", "go_ids": [], "go_terms": [], "name": "ASFV_p27_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010550": {"description": "2'-deoxycytidine 5'-triphosphate deaminase, N-terminal domain", "go_ids": ["GO:0009394", "GO:0008829"], "go_terms": ["GO:0009394:2'-deoxyribonucleotide metabolic process:P", "GO:0008829:dCTP deaminase activity:F"], "name": "DCD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010551": {"description": "Glucose-6-phosphate isomerase, prokaryote", "go_ids": ["GO:0004347", "GO:0005737", "GO:0006094", "GO:0006096"], "go_terms": ["GO:0004347:glucose-6-phosphate isomerase activity:F", "GO:0005737:cytoplasm:C", "GO:0006094:gluconeogenesis:P", "GO:0006096:glycolytic process:P"], "name": "G6P_isomerase_prok", "pathway_ids": ["PWY-7385", "PWY-5659", "PWY-5514", "PWY-6142", "PWY-7238", "PWY-622", "PWY-621", "PWY-6992", "PWY-7347", "PWY-6981", "PWY-5384", "PWY-8013", "PWY-3801", "PWY-5054"], "pathways": ["PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5659:t:GDP-mannose biosynthesis", "PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-7238:t:sucrose biosynthesis II", "PWY-622:t:starch biosynthesis", "PWY-621:t:sucrose degradation III (sucrose invertase)", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7347:t:sucrose biosynthesis III", "PWY-6981:t:chitin biosynthesis", "PWY-5384:t:sucrose degradation IV (sucrose phosphorylase)", "PWY-8013:t:UDP-N-acetyl-D-galactosamine biosynthesis III", "PWY-3801:t:sucrose degradation II (sucrose synthase)", "PWY-5054:t:D-sorbitol biosynthesis I"], "type": "Domain"}, "IPR010555": {"description": "CSPG5, sulphate attachment domain", "go_ids": [], "go_terms": [], "name": "CSPG5_S_attach_dom", "pathway_ids": ["R-HSA-2024101", "R-RNO-2022923", "R-HSA-3595174", "R-MMU-2022870", "R-RNO-1971475", "R-HSA-2022923", "R-HSA-2022870", "R-RNO-2024101", "R-HSA-3560783", "R-HSA-4420332", "R-HSA-3595177", "R-MMU-2024101", "R-HSA-1971475", "R-HSA-3595172", "R-MMU-1971475", "R-MMU-2022923", "R-RNO-2022870", "R-HSA-3560801"], "pathways": ["R-HSA-2024101:r:CS/DS degradation", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD"], "type": "Domain"}, "IPR010557": {"description": "Protein of unknown function DUF1133", "go_ids": [], "go_terms": [], "name": "DUF1133", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010558": {"description": "Caenorhabditis elegans ly-6-related", "go_ids": [], "go_terms": [], "name": "Ly-6-related", "pathway_ids": [], "pathways": [], 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"R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-RNO-373752:r:Netrin-1 signaling", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-376172:r:DSCAM interactions", "R-HSA-418885:r:DCC mediated attractive signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR010561": {"description": "Protein LIN-9/Protein ALWAYS EARLY", "go_ids": ["GO:0006351", "GO:0017053"], "go_terms": ["GO:0006351:DNA-templated transcription:P", "GO:0017053:transcription repressor complex:C"], "name": "LIN-9/ALY1", "pathway_ids": ["R-MMU-1538133", "R-HSA-69656", "R-CEL-1538133", "R-HSA-1362277", "R-HSA-69205", "R-HSA-1362300", "R-HSA-156711", "R-DRE-1538133", "R-HSA-1538133", "R-HSA-69202"], "pathways": ["R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-156711:r:Polo-like kinase mediated events", "R-DRE-1538133:r:G0 and Early G1", "R-HSA-1538133:r:G0 and Early G1", "R-HSA-69202:r:Cyclin E associated events during G1/S transition"], "type": "Family"}, "IPR010562": {"description": "Haemolymph juvenile hormone binding", "go_ids": [], "go_terms": [], "name": "Haemolymph_juvenile_hormone-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010563": {"description": "TraK, N-terminal", "go_ids": [], "go_terms": [], "name": "TraK_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010564": {"description": "Protein of unknown function DUF1137", "go_ids": [], "go_terms": [], "name": "DUF1137", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010565": {"description": "Muskelin, N-terminal", "go_ids": [], "go_terms": [], "name": "Muskelin_N", "pathway_ids": ["R-RNO-9861718", "R-HSA-9861718", "R-MMU-9861718"], "pathways": ["R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism"], "type": "Domain"}, "IPR010566": {"description": "Haemolysin-type calcium binding-related", "go_ids": [], "go_terms": [], "name": "Haemolys_ca-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010567": {"description": "Protein OrfX2/OrfX3/P47", "go_ids": [], "go_terms": [], "name": "OrfX2/OrfX3/P47", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010568": {"description": "Chlorovirus glycoprotein repeat", "go_ids": [], "go_terms": [], "name": "Chlorovirusi_glycop_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010569": {"description": "Myotubularin-like, phosphatase domain", "go_ids": [], "go_terms": [], "name": "Myotubularin-like_Pase_dom", "pathway_ids": ["R-SCE-1660516", "R-CEL-1660516", "R-BTA-1660499", "R-BTA-1660516", "R-HSA-1660517", "R-MMU-1660516", "R-DDI-1660499", "R-MMU-1632852", "R-SPO-1660499", "R-DRE-1660517", "R-HSA-1660499", "R-SPO-1660516", "R-MMU-1483248", "R-CEL-9035034", "R-RNO-1632852", "R-CEL-8876198", "R-SCE-1483248", "R-HSA-9035034", "R-SCE-1660517", "R-DDI-8876198", "R-DRE-1483248", "R-RNO-1660516", "R-HSA-1855183", "R-BTA-1660517", "R-DDI-1660517", "R-HSA-2173788", "R-BTA-1483248", "R-DDI-1483248", "R-MMU-9035034", "R-HSA-1483248", "R-DDI-1632852", "R-DDI-1660516", "R-SCE-1660499", "R-HSA-8876198", "R-HSA-1660516", "R-MMU-1660499", "R-CEL-1483248", "R-SCE-1632852", "R-RNO-1660517", "R-MMU-8876198", "R-RNO-1660499", "R-HSA-1632852", "R-CEL-1660499", "R-CEL-1660517", "R-SPO-1660517", "R-SPO-1483248", "R-MMU-2173788", "R-MMU-1660517", "R-DRE-1660516", "R-SPO-1632852", "R-DRE-1660499"], "pathways": ["R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1632852:r:Macroautophagy", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-9035034:r:RHOF GTPase cycle", "R-RNO-1632852:r:Macroautophagy", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-9035034:r:RHOF GTPase cycle", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-BTA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-1483248:r:Synthesis of PIPs at the ER membrane", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-DDI-1632852:r:Macroautophagy", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane", "R-SCE-1632852:r:Macroautophagy", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1632852:r:Macroautophagy", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DRE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SPO-1632852:r:Macroautophagy", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Domain"}, "IPR010570": {"description": "UpxZ family", "go_ids": [], "go_terms": [], "name": "UpxZ_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010571": {"description": "Outer membrane lipoprotein, Omp19, bacterial", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "OM_lipoprot_Omp19_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010572": {"description": "Tail spike domain", "go_ids": [], "go_terms": [], "name": "Tail_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010573": {"description": "Major facilitator transporter Str1/Tri12-like", "go_ids": ["GO:0055085", "GO:0022857"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "MFS_Str1/Tri12-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010574": {"description": "L-alanine exporter AlaE", "go_ids": ["GO:0034639", "GO:0016020"], "go_terms": ["GO:0034639:L-amino acid efflux transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "Ala_export_AlaE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010575": {"description": "KorB, C-terminal", "go_ids": ["GO:0003677", "GO:0045892"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "KorB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010578": {"description": "Single-minded, C-terminal", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "SIM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010579": {"description": "MHC class I, alpha chain, C-terminal", "go_ids": ["GO:0006955", "GO:0019882"], "go_terms": ["GO:0006955:immune 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MHC class I complex cell surface expression"], "type": "Domain"}, "IPR010580": {"description": "Stress-associated endoplasmic reticulum protein", "go_ids": ["GO:0005783"], "go_terms": ["GO:0005783:endoplasmic reticulum:C"], "name": "ER_stress-assoc", "pathway_ids": ["R-MMU-9609523", "R-HSA-381038", "R-HSA-9609523", "R-DDI-9609523", "R-BTA-9609523", "R-RNO-9609523"], "pathways": ["R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Family"}, "IPR010581": {"description": "Protein of unknown function DUF1152", "go_ids": [], "go_terms": [], "name": "DUF1152", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010582": {"description": "Catalase immune-responsive domain", "go_ids": [], "go_terms": [], "name": "Catalase_immune_responsive", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-HSA-3299685", "R-SPO-6798695", "R-DRE-3299685", "R-CFA-9033241", "R-DME-6798695", "R-DME-9033241", "R-SCE-6798695", "R-HSA-9841251", "R-BTA-6798695", "R-MMU-9033241", "R-MMU-3299685", "R-RNO-3299685", "R-BTA-9033241", "R-DDI-3299685", "R-RNO-9033241", "R-SCE-3299685", "R-SPO-9033241", "R-HSA-9615017", "R-BTA-3299685", "R-SPO-3299685", "R-DRE-6798695", "R-CFA-3299685", "R-SCE-9033241", "R-MMU-6798695", "R-CFA-6798695", "R-DME-3299685", "R-DDI-9033241", "R-HSA-9033241", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-3299685:r:Detoxification of Reactive Oxygen Species", "R-CFA-9033241:r:Peroxisomal protein import", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-9033241:r:Peroxisomal protein import", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9033241:r:Peroxisomal protein import", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-9033241:r:Peroxisomal protein import", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-DRE-6798695:r:Neutrophil degranulation", "R-CFA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SCE-9033241:r:Peroxisomal protein import", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-6798695:r:Neutrophil degranulation", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR010583": {"description": "MltA-interacting MipA", "go_ids": [], "go_terms": [], "name": "MipA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010584": {"description": "Exodeoxyribonuclease 8", "go_ids": ["GO:0051908"], "go_terms": ["GO:0051908:double-stranded DNA 5'-3' DNA exonuclease activity:F"], "name": "ExoDNase_VIII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010585": {"description": "DNA repair protein XRCC4", "go_ids": ["GO:0003677", "GO:0005634", "GO:0006302", "GO:0006310"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006302:double-strand break repair:P", "GO:0006310:DNA recombination:P"], "name": "DNA_repair_prot_XRCC4", "pathway_ids": ["R-HSA-5693571", "R-MMU-3108214", "R-DDI-5693571", "R-HSA-3108214", "R-MMU-5693571", "R-DDI-3108214", "R-HSA-164843"], "pathways": ["R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-164843:r:2-LTR circle formation"], "type": "Family"}, "IPR010586": {"description": "Type 3 secretion system stator protein", "go_ids": [], "go_terms": [], "name": "T3SS_stator_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010587": {"description": "Melanoplus sanguinipes 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DUF1159", "go_ids": [], "go_terms": [], "name": "DUF1159", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010594": {"description": "Autographa californica nuclear polyhedrosis virus (AcMNPV), Ac75", "go_ids": [], "go_terms": [], "name": "AcMNPV_Ac75", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010595": {"description": "Protein of unknown function DUF1161", "go_ids": [], "go_terms": [], "name": "DUF1161", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010596": {"description": "Methuselah, N-terminal domain", "go_ids": ["GO:0004930"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F"], "name": "Methuselah_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010598": {"description": "D-glucuronyl C5-epimerase, C-terminal", "go_ids": [], "go_terms": [], "name": "C5-epim_C", "pathway_ids": ["PWY-6558", "R-HSA-2022928"], "pathways": ["PWY-6558:t:heparan sulfate biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis"], "type": "Domain"}, "IPR010599": {"description": "Connector enhancer of kinase suppressor of ras 2/3 domain", "go_ids": ["GO:0005737", "GO:0009966", "GO:0016020"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0009966:regulation of signal transduction:P", "GO:0016020:membrane:C"], "name": "CNK2/3_dom", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-9649948", "R-HSA-6802952", "R-HSA-6802946", "R-RNO-5674135", "R-HSA-6802955", "R-HSA-9656223"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Domain"}, "IPR010600": {"description": "Inter-alpha-trypsin inhibitor heavy chain, C-terminal", "go_ids": ["GO:0004867", "GO:0030212"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F", "GO:0030212:hyaluronan metabolic process:P"], "name": "ITI_HC_C", "pathway_ids": ["R-HSA-114608", "R-BTA-114608", "R-SSC-381426", "R-SSC-8957275", "R-MMU-381426", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR010601": {"description": "Protein of unknown function DUF1182", "go_ids": [], "go_terms": [], "name": "DUF1182", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010602": {"description": "Protein of unknown function DUF1186", "go_ids": [], "go_terms": [], "name": "DUF1186", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010603": {"description": "ATP-dependent Clp protease ATP-binding subunit ClpX, zinc ribbon domain", "go_ids": ["GO:0008270", "GO:0046983"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0046983:protein dimerization activity:F"], "name": "Znf_CppX_C4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010604": {"description": "Plant AUGMIN subunit 7", "go_ids": ["GO:0051011"], "go_terms": ["GO:0051011:microtubule minus-end binding:F"], "name": "Plant_AUG7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010605": {"description": "Protein of unknown function DUF1191", "go_ids": [], "go_terms": [], "name": "DUF1191", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010606": {"description": "Mib-herc2", "go_ids": ["GO:0004842", "GO:0016567", "GO:0046872"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F", "GO:0016567:protein ubiquitination:P", "GO:0046872:metal ion binding:F"], "name": "Mib_Herc2", "pathway_ids": ["R-DME-983168", "R-MMU-5357786", "R-HSA-3108214", "R-HSA-2122948", "R-HSA-69473", "R-HSA-2894862", "R-HSA-9931295", "R-RNO-5357905", "R-HSA-5693565", "R-HSA-983168", "R-HSA-5357786", "R-MMU-5693565", "R-MMU-69473", "R-RNO-9931295", "R-MMU-9931295", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-2979096", "R-HSA-5357905", "R-MMU-5357905", "R-MMU-983168", "R-HSA-2644606", "R-MMU-3108214", "R-HSA-9013507", "R-RNO-5357786", "R-RNO-983168", "R-HSA-2691232", "R-MMU-5693571", "R-MMU-5693607"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Domain"}, "IPR010607": {"description": "Protein of unknown function DUF1194", "go_ids": [], "go_terms": [], "name": "DUF1194", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010608": {"description": "Protein of unknown function DUF1195", "go_ids": [], "go_terms": [], "name": "DUF1195", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010609": {"description": "Gp5, C-terminal", "go_ids": [], "go_terms": [], "name": "Gp5_C", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010610": {"description": "Erythromycin biosynthesis protein CIII-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "EryCIII-like_C", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR010611": {"description": "3D domain", "go_ids": ["GO:0004553", "GO:0009254", "GO:0019867"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0009254:peptidoglycan turnover:P", "GO:0019867:outer membrane:C"], "name": "3D_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010613": {"description": "Pescadillo", "go_ids": ["GO:0042254", "GO:0005730"], "go_terms": ["GO:0042254:ribosome biogenesis:P", "GO:0005730:nucleolus:C"], "name": "PES", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DRE-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR010614": {"description": "RAD3-like helicase, DEAD", "go_ids": ["GO:0003677", "GO:0003678", "GO:0005524"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003678:DNA helicase activity:F", "GO:0005524:ATP binding:F"], "name": "RAD3-like_helicase_DEAD", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-MMU-113418", "R-HSA-5693616", "R-HSA-5693579", "R-HSA-427413", "R-BTA-76042", "R-GGA-5693616", "R-DDI-73776", "R-MMU-6804756", "R-DDI-6782210", "R-SPO-6781823", "R-MMU-5693616", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-5685938", "R-MMU-112382", "R-HSA-6781823", "R-MMU-69473", "R-MMU-5696395", "R-HSA-167246", "R-SPO-5696395", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-HSA-9709570", "R-DDI-674695", "R-HSA-5693607", "R-HSA-75953", "R-HSA-77075", "R-MMU-5693568", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-BTA-73863", "R-BTA-75955", "R-SPO-113418", "R-BTA-75953", "R-DDI-73779", "R-BTA-72086", "R-HSA-69473", "R-BTA-6782135", "R-DDI-6781823", "R-DDI-72086", "R-DRE-171319", "R-MMU-674695", "R-SCE-76042", "R-MMU-171319", "R-HSA-167161", "R-HSA-167200", "R-HSA-6804756", "R-HSA-9704331", "R-SCE-674695", "R-HSA-167160", "R-HSA-5696395", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-MMU-73772", "R-MMU-6782210", "R-MMU-72086", "R-GGA-5693607", "R-BTA-73772", "R-BTA-73776", "R-SPO-73776", "R-DDI-113418", "R-HSA-5693554", "R-SCE-6782135", "R-SCE-73776", "R-DDI-6782135", "R-GGA-351465", "R-MMU-73762", "R-GGA-5685938", "R-DDI-5696395", "R-HSA-6781827", "R-HSA-5685942", "R-MMU-6782135", "R-GGA-5685942", "R-BTA-113418", "R-HSA-9704646", "R-HSA-72086", "R-RNO-171319", "R-HSA-171319", "R-HSA-167162", "R-BTA-6781823", "R-MMU-6781823", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696395", "R-MMU-5693579", "R-BTA-5696400", "R-SCE-6782210", "R-HSA-167172", "R-BTA-6796648", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5696400", "R-BTA-73779", "R-SCE-6796648", "R-MMU-5693607", "R-HSA-9701192", "R-BTA-73762", "R-SCE-73779", "R-HSA-2564830", "R-SPO-77075", "R-HSA-381038", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-GGA-5693568", "R-MMU-73863", "R-SCE-6781823", "R-HSA-6782135", "R-BTA-674695", "R-HSA-73762", "R-MMU-5685942", "R-HSA-9709603", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-SPO-5696400", "R-SCE-77075", "R-HSA-75955", "R-SPO-6782210", "R-HSA-5696400", "R-HSA-674695", "R-HSA-76042", "R-SPO-6782135", "R-SCE-73772", "R-DDI-75953", "R-GGA-5693579", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782135:r:Dual incision in TC-NER", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-72086:r:mRNA Capping", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-GGA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-GGA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR010615": {"description": "Herpesvirus UL97", "go_ids": ["GO:0004672", "GO:0005524", "GO:0016032"], "go_terms": ["GO:0004672:protein kinase activity:F", "GO:0005524:ATP binding:F", "GO:0016032:viral process:P"], "name": "Herpes_UL97", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Domain"}, "IPR010617": {"description": "Endosomal/lysosomal proton channel TMEM175-like", "go_ids": ["GO:0015252", "GO:0005267"], "go_terms": ["GO:0015252:proton channel activity:F", "GO:0005267:potassium channel activity:F"], "name": "TMEM175-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010618": {"description": "Resuscitation-promoting factor, core lysozyme-like domain", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "RPF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010619": {"description": "Threonine/serine exporter-like, N-terminal domain", "go_ids": ["GO:0055085", "GO:0022857"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "ThrE-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010620": {"description": "Seven Bladed Beta Propeller repeat", "go_ids": [], "go_terms": [], "name": "SBBP_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010621": {"description": "Domain of unknown function DUF1214", "go_ids": [], "go_terms": [], "name": "DUF1214", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010622": {"description": "FAST kinase leucine-rich", "go_ids": ["GO:0044528"], "go_terms": ["GO:0044528:regulation of mitochondrial mRNA stability:P"], "name": "FAST_Leu-rich", "pathway_ids": ["R-HSA-9837092", "R-HSA-9937008", "R-HSA-6793080"], "pathways": ["R-HSA-9837092:r:FASTK family proteins regulate processing and stability of mitochondrial RNAs", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Domain"}, "IPR010623": {"description": "Type VI secretion system IcmF, C-terminal", "go_ids": [], "go_terms": [], "name": "IcmF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010625": {"description": "CHCH", "go_ids": [], "go_terms": [], "name": "CHCH", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-MMU-6799198", "R-HSA-6799198", "R-HSA-9937383", "R-BTA-9864848", "R-BTA-6799198", "R-HSA-9864848", "R-HSA-611105", "R-HSA-5368286", "R-HSA-1268020", "R-MMU-611105", "R-MMU-5419276", "R-MMU-9864848", "R-HSA-9837999", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-611105"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-9864848:r:Complex IV assembly", "R-BTA-6799198:r:Complex I biogenesis", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-MMU-9864848:r:Complex IV assembly", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR010626": {"description": "Protein of unknown function DUF1217", "go_ids": [], "go_terms": [], "name": "DUF1217", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010627": {"description": "Prepilin peptidase A24, N-terminal", "go_ids": [], "go_terms": [], "name": "Prepilin_pept_A24_N", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR010628": {"description": "Ethanolamine ammonia-lyase heavy chain", "go_ids": ["GO:0006520", "GO:0008851"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0008851:ethanolamine ammonia-lyase activity:F"], "name": "EutB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010629": {"description": "Insect allergen-related", "go_ids": [], "go_terms": [], "name": "Ins_allergen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010630": {"description": "Olduvai domain", "go_ids": [], "go_terms": [], "name": "Olduvai_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010632": {"description": "Domain of unknown function DUF1221", "go_ids": [], "go_terms": [], "name": "DUF1221", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010633": {"description": "Bacteriophage lambda, GpZ, minor tail", "go_ids": [], "go_terms": [], "name": "Phage_lambda_GpZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010634": {"description": "Protein of unknown function DUF1223", "go_ids": [], "go_terms": [], "name": "DUF1223", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010635": {"description": "Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase", "go_ids": ["GO:0008146", "GO:0016020"], "go_terms": ["GO:0008146:sulfotransferase activity:F", "GO:0016020:membrane:C"], "name": "Heparan_SO4-6-sulfoTrfase", "pathway_ids": ["PWY-8045", "PWY-7831", "PWY-8381", "PWY-6558", "PWY-6546", "PWY-6568", "PWY-6567", "PWY-8358", "R-MMU-2022928", "R-GGA-2022928", "R-HSA-2022928", "R-DRE-2022928"], "pathways": ["PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7831:t:ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-6546:t:brassinosteroids inactivation", "PWY-6568:t:dermatan sulfate biosynthesis", "PWY-6567:t:chondroitin sulfate biosynthesis", "PWY-8358:t:curacin A biosynthesis", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-GGA-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-DRE-2022928:r:HS-GAG biosynthesis"], "type": "Family"}, "IPR010636": {"description": "Class II hydrophobin", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Class_II_hydrophobin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010637": {"description": "Sif", "go_ids": [], "go_terms": [], "name": "Sif", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010639": {"description": "Actin-rearrangement-inducing factor", "go_ids": [], "go_terms": [], "name": "Actin-rearrang-inducing_fac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010640": {"description": "Low temperature requirement A", "go_ids": [], "go_terms": [], "name": "Low_temperature_requirement_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010642": {"description": "Invasion protein B", "go_ids": [], "go_terms": [], "name": "Invasion_prot_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010643": {"description": "Helical and beta-bridge domain", "go_ids": [], "go_terms": [], "name": "HBB", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-MMU-113418", "R-HSA-427413", "R-BTA-76042", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-MMU-5696395", "R-HSA-167246", "R-SPO-5696395", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-DDI-674695", "R-HSA-75953", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-BTA-73863", "R-BTA-75955", "R-SPO-113418", "R-BTA-75953", "R-DDI-73779", "R-BTA-72086", "R-BTA-6782135", "R-DDI-6781823", "R-DDI-72086", "R-MMU-674695", "R-SCE-76042", "R-HSA-167161", "R-HSA-167200", "R-SCE-674695", "R-HSA-167160", "R-HSA-5696395", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-MMU-73772", "R-MMU-6782210", "R-MMU-72086", "R-DDI-113418", "R-BTA-73772", "R-BTA-73776", "R-SPO-73776", "R-SCE-6782135", "R-SCE-73776", "R-DDI-6782135", "R-MMU-73762", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-BTA-113418", "R-HSA-72086", "R-HSA-167162", "R-BTA-6781823", "R-MMU-6781823", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696395", "R-BTA-5696400", "R-SCE-6782210", "R-HSA-167172", "R-BTA-6796648", "R-MMU-5696400", "R-BTA-73779", "R-SCE-6796648", "R-BTA-73762", "R-SCE-73779", "R-HSA-2564830", "R-SPO-77075", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-MMU-73863", "R-SCE-6781823", "R-HSA-6782135", "R-BTA-674695", "R-HSA-73762", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-SPO-5696400", "R-SCE-77075", "R-HSA-75955", "R-SPO-6782210", "R-HSA-5696400", "R-HSA-674695", "R-HSA-76042", "R-SPO-6782135", "R-SCE-73772", "R-DDI-75953", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-72086:r:mRNA Capping", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR010644": {"description": "Heme-dependent peroxidase ChdC/CLD", "go_ids": ["GO:0020037", "GO:0016491"], "go_terms": ["GO:0020037:heme binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "ChdC/CLD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010645": {"description": "Putative MFS transporter YjiJ", "go_ids": [], "go_terms": [], "name": "MFS_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010646": {"description": "Uncharacterised protein family UPF0257", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "UPF0257", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010648": {"description": "Uncharacterised protein family UPF0270", "go_ids": [], "go_terms": [], "name": "UPF0270", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010649": {"description": "Nitrate/trimethylamine N-oxide reductase NapE/TorE", "go_ids": [], "go_terms": [], "name": "NapE_TorE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010650": {"description": "PrkA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PrkA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010651": {"description": "Sugar transport protein", "go_ids": ["GO:0015144", "GO:0016020", "GO:0034219"], "go_terms": ["GO:0015144:carbohydrate transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0034219:carbohydrate transmembrane transport:P"], "name": "Sugar_transport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010652": {"description": "Domain of unknown function DUF1232", "go_ids": [], "go_terms": [], "name": "DUF1232", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR010653": {"description": "Outer membrane protein assembly factor BamC-like", "go_ids": [], "go_terms": [], "name": "BamC-like", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR010654": {"description": "Bacteriophage lambda tail assembly I", "go_ids": [], "go_terms": [], "name": "Phage_lambda_tail_I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010655": {"description": "Clp1, C-terminal", "go_ids": ["GO:0031124"], "go_terms": ["GO:0031124:mRNA 3'-end processing:P"], "name": "Clp1_C", "pathway_ids": ["R-HSA-9770562", "R-DRE-77595", "R-DME-77595", "R-GGA-73856", "R-XTR-9770562", "R-MMU-9770562", "R-HSA-6784531", "R-MMU-77595", "R-BTA-73856", "R-RNO-77595", "R-HSA-73856", "R-DDI-9770562", "R-CEL-73856", "R-MMU-73856", "R-HSA-72187", "R-CEL-77595", "R-RNO-73856", "R-SCE-9770562", "R-SPO-9770562", "R-DME-9770562", "R-HSA-77595", "R-DRE-73856", "R-MMU-72187", "R-DRE-9770562", "R-CEL-9770562", "R-RNO-9770562", "R-BTA-9770562", "R-GGA-9770562", "R-DME-73856", "R-HSA-9918481", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-SCE-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-DRE-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-GGA-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR010656": {"description": "TRAP C4-dicarboxylate transport system permease DctM subunit", "go_ids": [], "go_terms": [], "name": "DctM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010657": {"description": "ImpA, N-terminal", "go_ids": [], "go_terms": [], "name": "ImpA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010658": {"description": "Nodulin-like", "go_ids": [], "go_terms": [], "name": "Nodulin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010659": {"description": "Reverse transcriptase connection", "go_ids": ["GO:0003964", "GO:0006278"], "go_terms": ["GO:0003964:RNA-directed DNA polymerase activity:F", "GO:0006278:RNA-templated DNA biosynthetic process:P"], "name": "RVT_connect", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-164843", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164525", "R-HSA-173107", "R-HSA-162594"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Domain"}, "IPR010660": {"description": "Notch, NOD domain", "go_ids": ["GO:0016020", "GO:0030154"], "go_terms": ["GO:0016020:membrane:C", "GO:0030154:cell differentiation:P"], "name": "Notch_NOD_dom", "pathway_ids": ["R-XTR-2979096", "R-HSA-8941856", "R-HSA-9604323", "R-HSA-2122948", "R-RNO-9017802", "R-MMU-2122947", "R-XTR-8941856", "R-MMU-2122948", "R-HSA-9818749", "R-XTR-2122948", "R-HSA-9824272", "R-XTR-2197563", "R-XTR-1912420", "R-HSA-1912408", "R-RNO-350054", "R-MMU-1912420", "R-HSA-5083630", "R-HSA-2979096", "R-HSA-9017802", "R-HSA-9818030", "R-HSA-9013700", "R-MMU-9013507", "R-RNO-1912420", "R-HSA-2691232", "R-HSA-9013507", "R-HSA-2122947", "R-MMU-9013700", "R-HSA-1912420", "R-HSA-9013508", "R-CEL-2979096", "R-HSA-210744", "R-HSA-2894862", "R-XTR-9013507", "R-RNO-9013507", "R-MMU-9017802", "R-HSA-350054", "R-MMU-9604323", "R-HSA-9013695", "R-HSA-2644607", "R-HSA-2660826", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-1912399", "R-XTR-9017802"], "pathways": ["R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9824272:r:Somitogenesis", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-CEL-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-XTR-9017802:r:Noncanonical activation of NOTCH3"], "type": "Domain"}, "IPR010661": {"description": "Reverse transcriptase thumb", "go_ids": ["GO:0003964", "GO:0006278"], "go_terms": ["GO:0003964:RNA-directed DNA polymerase activity:F", "GO:0006278:RNA-templated DNA biosynthetic process:P"], "name": "RVT_thumb", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-164843", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164525", "R-HSA-173107", "R-HSA-162594"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Domain"}, "IPR010662": {"description": "Serine hydrolase RBBP9/YdeN", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "RBBP9/YdeN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010663": {"description": "Zinc finger, FPG/IleRS-type", "go_ids": [], "go_terms": [], "name": "Znf_FPG/IleRS", "pathway_ids": ["R-HSA-379726", "R-HSA-9837999", "R-MMU-9837999"], "pathways": ["R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation"], "type": "Domain"}, "IPR010664": {"description": "Lipopolysaccharide assembly, LptC-related", "go_ids": [], "go_terms": [], "name": "LipoPS_assembly_LptC-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010665": {"description": "Protein of unknown function DUF1240", "go_ids": [], "go_terms": [], "name": "DUF1240", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010666": {"description": "Zinc finger, GRF-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_GRF", "pathway_ids": ["R-MMU-110330", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-HSA-9636003", "R-HSA-110328", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-110331", "R-MMU-69473", "R-HSA-110331", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9629232", "R-HSA-9704331", "R-HSA-912446", "R-HSA-110329", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-110330", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-9636003:r:NEIL3-mediated resolution of ICLs", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9629232:r:Defective Base Excision Repair Associated with NEIL3", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR010667": {"description": "Bacteriophage T4, Gp19, tail tube", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Phage_T4_Gp19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010671": {"description": "Disaggregatase-related domain", "go_ids": [], "go_terms": [], "name": "Disaggr-rel_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010672": {"description": "IMP biosynthesis enzyme PurP, N-terminal", "go_ids": ["GO:0000287", "GO:0005524", "GO:0006188", "GO:0016879"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0005524:ATP binding:F", "GO:0006188:IMP biosynthetic process:P", "GO:0016879:ligase activity, forming carbon-nitrogen bonds:F"], "name": "IMP_biosynth_PurP_N", "pathway_ids": ["PWY-7234"], "pathways": ["PWY-7234:t:inosine-5'-phosphate biosynthesis III"], "type": "Domain"}, "IPR010673": {"description": "Protein of unknown function UPF0346", "go_ids": [], "go_terms": [], "name": "UPF0346", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010674": {"description": "Nucleolar GTP-binding protein 1, Rossman-fold domain", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "NOG1_Rossman_fold_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010675": {"description": "RNA methyltransferase bin3, C-terminal", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "Bin3_C", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-203927"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR010677": {"description": "Human herpes virus type 4, BALF1", "go_ids": [], "go_terms": [], "name": "HHV-4_BALF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010678": {"description": "U3 small nucleolar RNA-associated protein 25", "go_ids": ["GO:0005730", "GO:0034511", "GO:0006364"], "go_terms": ["GO:0005730:nucleolus:C", "GO:0034511:U3 snoRNA binding:F", "GO:0006364:rRNA processing:P"], "name": "UTP25", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR010679": {"description": "Domain of unknown function DUF1254", "go_ids": [], "go_terms": [], "name": "DUF1254", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010680": {"description": "TraH-2", "go_ids": [], "go_terms": [], "name": "TraH_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010681": {"description": "Plethodontid receptivity factor PRF/cardiotrophin-like", "go_ids": [], "go_terms": [], "name": "PRF/CT", "pathway_ids": ["R-MMU-6788467", "R-HSA-6788467", "R-RNO-6788467"], "pathways": ["R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Family"}, "IPR010682": {"description": "Plant self-incompatibility response", "go_ids": ["GO:0007165"], "go_terms": ["GO:0007165:signal transduction:P"], "name": "SCRL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010683": {"description": "Protein of unknown function DUF1262", "go_ids": [], "go_terms": [], "name": "DUF1262", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010684": {"description": "RNA polymerase II transcription factor SIII, subunit A", "go_ids": ["GO:0006368", "GO:0005634", "GO:0070449"], "go_terms": ["GO:0006368:transcription elongation by RNA polymerase II:P", "GO:0005634:nucleus:C", "GO:0070449:elongin complex:C"], "name": "RNA_pol_II_trans_fac_SIII_A", "pathway_ids": ["R-CEL-75955", "R-MMU-6796648", "R-HSA-167238", "R-RNO-674695", "R-HSA-167243", "R-RNO-6796648", "R-RNO-75955", "R-DME-674695", "R-DME-6796648", "R-HSA-6796648", "R-DME-75955", "R-MMU-674695", "R-MMU-75955", "R-MMU-112382", "R-CEL-674695", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-75955", "R-CEL-112382", "R-HSA-167152", "R-RNO-112382", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Family"}, "IPR010685": {"description": "Domain of unknown function DUF1263", "go_ids": [], "go_terms": [], "name": "DUF1263", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010686": {"description": "Oil body-associated protein-like", "go_ids": [], "go_terms": [], "name": "OBAP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010690": {"description": "Putative stage IV sporulation YqfD", "go_ids": [], "go_terms": [], "name": "YqfD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010691": {"description": "Probable ECA polymerase WzyE", "go_ids": ["GO:0009246", "GO:0016020"], "go_terms": ["GO:0009246:enterobacterial common antigen biosynthetic process:P", "GO:0016020:membrane:C"], "name": "WzyE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010692": {"description": "RTX iron-regulated FrpC", "go_ids": [], "go_terms": [], "name": "FrpC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010693": {"description": "Divergent 4Fe-4S mono-cluster", "go_ids": [], "go_terms": [], "name": "Divergent_4Fe-4S_mono-cluster", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010694": {"description": "Uncharacterised protein family VirK", "go_ids": [], "go_terms": [], "name": "Uncharacterised_VirK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010695": {"description": "Fas apoptotic inhibitory molecule 1", "go_ids": ["GO:0043066"], "go_terms": ["GO:0043066:negative regulation of apoptotic process:P"], "name": "FAIM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010696": {"description": "Protein of unknown function DUF1272", "go_ids": [], "go_terms": [], "name": "DUF1272", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010697": {"description": "YspA SLOG family", "go_ids": [], "go_terms": [], "name": "YspA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010699": {"description": "Protein of unknown function DUF1275", "go_ids": [], "go_terms": [], "name": "DUF1275", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010702": {"description": "Periplasmic pectate lyase", "go_ids": ["GO:0016837", "GO:0045490", "GO:0042597"], "go_terms": ["GO:0016837:carbon-oxygen lyase activity, acting on polysaccharides:F", "GO:0045490:pectin catabolic process:P", "GO:0042597:periplasmic space:C"], "name": "Pectate_lyase_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010706": {"description": "Fatty acid cis-trans isomerase", "go_ids": [], "go_terms": [], "name": "Fatty_acid_cis-trans_isomerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010707": {"description": "Protein of unknown function DUF1285", "go_ids": [], "go_terms": [], "name": "DUF1285", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010708": {"description": "5'(3')-deoxyribonucleotidase", "go_ids": ["GO:0008253", "GO:0009264"], "go_terms": ["GO:0008253:5'-nucleotidase activity:F", "GO:0009264:deoxyribonucleotide catabolic process:P"], "name": "5'(3')-deoxyribonucleotidase", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664", "R-MMU-74259", "R-HSA-74259", "R-MMU-73621", "R-HSA-73621"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "R-MMU-74259:r:Purine catabolism", "R-HSA-74259:r:Purine catabolism", "R-MMU-73621:r:Pyrimidine catabolism", "R-HSA-73621:r:Pyrimidine catabolism"], "type": "Family"}, "IPR010710": {"description": "Protein of unknown function DUF1289", "go_ids": [], "go_terms": [], "name": "DUF1289", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010711": {"description": "Group XII secretory phospholipase A2 precursor", "go_ids": ["GO:0004623", "GO:0005509", "GO:0005576", "GO:0016042"], "go_terms": ["GO:0004623:A2-type glycerophospholipase activity:F", "GO:0005509:calcium ion binding:F", "GO:0005576:extracellular region:C", "GO:0016042:lipid catabolic process:P"], "name": "PLA2G12", "pathway_ids": ["R-MMU-1483166", "R-HSA-1482922", "R-MMU-1482922", "R-HSA-1482839", "R-MMU-1482788", "R-HSA-1483166", "R-MMU-1482925", "R-MMU-1482801", "R-MMU-1482839", "R-HSA-1482925", "R-HSA-1482801", "R-HSA-1482788"], "pathways": ["R-MMU-1483166:r:Synthesis of PA", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-HSA-1483166:r:Synthesis of PA", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Family"}, "IPR010712": {"description": "Arsenical-resistance operon trans-acting repressor ArsD", "go_ids": ["GO:0003677", "GO:0045892", "GO:0046685"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0046685:response to arsenic-containing substance:P"], "name": "Arsenical-R_ArsD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010713": {"description": "Xyloglucan endo-transglycosylase, C-terminal", "go_ids": ["GO:0044042", "GO:0005618", "GO:0016762", "GO:0048046"], "go_terms": ["GO:0044042:glucan metabolic process:P", "GO:0005618:cell wall:C", "GO:0016762:xyloglucan:xyloglucosyl transferase activity:F", "GO:0048046:apoplast:C"], "name": "XET_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010714": {"description": "Coatomer, alpha subunit, C-terminal", "go_ids": ["GO:0005198", "GO:0005515", "GO:0006886", "GO:0016192", "GO:0030126"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0005515:protein binding:F", "GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P", "GO:0030126:COPI vesicle coat:C"], "name": "Coatomer_asu_C", "pathway_ids": ["R-SPO-6807878", "R-HSA-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-DDI-6807878", "R-SPO-6811434", "R-HSA-6807878", "R-MMU-6807878", "R-DDI-6811434", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR010716": {"description": "RecQ helicase-like 5", "go_ids": [], "go_terms": [], "name": "RECQ5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010718": {"description": "Protein of unknown function DUF1294", "go_ids": [], "go_terms": [], "name": "DUF1294", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010719": {"description": "Methyltransferase MnmM-like", "go_ids": [], "go_terms": [], "name": "MnmM_MeTrfase", "pathway_ids": ["PWY-7892"], "pathways": ["PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)"], "type": "Family"}, "IPR010720": {"description": "Alpha-L-arabinofuranosidase, C-terminal", "go_ids": ["GO:0046373", "GO:0046556"], "go_terms": ["GO:0046373:L-arabinose metabolic process:P", "GO:0046556:alpha-L-arabinofuranosidase activity:F"], "name": "Alpha-L-AF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010721": {"description": "Probable O-methyltransferase UstE-like", "go_ids": [], "go_terms": [], "name": "UstE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010722": {"description": "Biotin and thiamin synthesis-associated domain", "go_ids": [], "go_terms": [], "name": "BATS_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010723": {"description": "HemN, C-terminal", "go_ids": [], "go_terms": [], "name": "HemN_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010724": {"description": "Replication initiator A, N-terminal", "go_ids": [], "go_terms": [], "name": "RepA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010725": {"description": "Domain of unknown function DUF1299", "go_ids": [], "go_terms": [], "name": "DUF1299", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010727": {"description": "Protein of unknown function DUF1302", "go_ids": [], "go_terms": [], "name": "DUF1302", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010729": {"description": "Large ribosomal subunit protein uL29m, mitochondrial", "go_ids": ["GO:0003735", "GO:0005761", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005761:mitochondrial ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uL29_mit", "pathway_ids": ["R-MMU-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Family"}, "IPR010730": {"description": "Heterokaryon incompatibility", "go_ids": [], "go_terms": [], "name": "HET", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010732": {"description": "Type VI secretion, TssG-like", "go_ids": [], "go_terms": [], "name": "T6SS_TssG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010733": {"description": "Domain of unknown function DUF1308", "go_ids": [], "go_terms": [], "name": "DUF1308", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010734": {"description": "Copine, C-terminal", "go_ids": [], "go_terms": [], "name": "Copine_C", "pathway_ids": ["R-HSA-6798695", "R-MMU-1483206", "R-DDI-6798695", "R-HSA-9013405", "R-HSA-9013409", "R-MMU-9013406", "R-HSA-9013148", "R-BTA-1483206", "R-DDI-1483206", "R-MMU-6798695", "R-BTA-6798695", "R-HSA-1483206", "R-HSA-9013406", "R-RNO-1483206", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-1483206:r:Glycerophospholipid biosynthesis", "R-DDI-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-1483206:r:Glycerophospholipid biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR010736": {"description": "Sperm-tail PG-rich repeat", "go_ids": [], "go_terms": [], "name": "SHIPPO-rpt", "pathway_ids": ["R-HSA-9821002"], "pathways": ["R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)"], "type": "Repeat"}, "IPR010737": {"description": "Four-carbon acid sugar kinase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "4-carb_acid_sugar_kinase_N", "pathway_ids": ["PWY-7873", "PWY-7874"], "pathways": ["PWY-7873:t:D-erythronate degradation II", "PWY-7874:t:L-threonate degradation"], "type": "Domain"}, "IPR010738": {"description": "Protein of unknown function DUF1310", "go_ids": [], "go_terms": [], "name": "DUF1310", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010740": {"description": "Endomucin", "go_ids": [], "go_terms": [], "name": "Endomucin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010741": {"description": "Protein of unknown function DUF1314", "go_ids": [], "go_terms": [], "name": "DUF1314", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010742": {"description": "Respirasome Complex Assembly Factor 1", "go_ids": ["GO:0097250"], "go_terms": ["GO:0097250:mitochondrial respirasome assembly:P"], "name": "RCAF1", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR010743": {"description": "Methionine biosynthesis MetW", "go_ids": [], "go_terms": [], "name": "Methionine_synth_MetW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010744": {"description": "Bacteriophage CI repressor, N-terminal", "go_ids": ["GO:0003677", "GO:0045892"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "Phage_CI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010746": {"description": "Commelina yellow mottle virus, Orf1", "go_ids": [], "go_terms": [], "name": "CYMV_Orf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010749": {"description": "YfeC-like", "go_ids": [], "go_terms": [], "name": "YfeC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010750": {"description": "SGF29 tudor-like domain", "go_ids": [], "go_terms": [], "name": "SGF29_tudor-like_dom", "pathway_ids": ["R-MMU-9772755", "R-HSA-3214847", "R-RNO-9772755", "R-HSA-9772755"], "pathways": ["R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Domain"}, "IPR010751": {"description": "Plasmid replication initiator protein TrfA", "go_ids": [], "go_terms": [], "name": "TrfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010752": {"description": "Protein of unknown function DUF1329", "go_ids": [], "go_terms": [], "name": "DUF1329", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010753": {"description": "Domain of unknown function DUF1330", "go_ids": [], "go_terms": [], "name": "DUF1330", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010754": {"description": "Optic atrophy 3-like", "go_ids": [], "go_terms": [], "name": "OPA3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010756": {"description": "Telomere length and silencing protein 1-like", "go_ids": [], "go_terms": [], "name": "Tls1-like", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR010758": {"description": "Trans-2-enoyl-CoA reductase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Trans-2-enoyl-CoA_reductase", "pathway_ids": ["PWY-7664", "PWY-8175", "PWY-7858", "PWY-8174", "PWY-8203", "PWY-7663", "PWYG-321", "PWY-5971", "PWY-5973", "PWY-5989", "PWY-6519", "PWY-6282", "PWY-8173"], "pathways": ["PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWYG-321:t:mycolate biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis"], "type": "Family"}, "IPR010760": {"description": "DNA repair protein, Swi5", "go_ids": [], "go_terms": [], "name": "DNA-repair_Swi5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010761": {"description": "Clc protein-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Clc_prot-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010762": {"description": "Capsid protein, T4-like bacteriophage-like", "go_ids": [], "go_terms": [], "name": "Gp23/Gp24_T4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010763": {"description": "2-dehydro-3-deoxy-phosphogluconate aldolase", "go_ids": [], "go_terms": [], "name": "DgaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010764": {"description": "Protein of unknown function DUF1347", "go_ids": [], "go_terms": [], "name": "DUF1347", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010765": {"description": "Protein of unknown function DUF1350", "go_ids": [], "go_terms": [], "name": "DUF1350", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010766": {"description": "DRTGG", "go_ids": [], "go_terms": [], "name": "DRTGG", "pathway_ids": ["PWY-8086", "PWY-1281", "PWY-8377", "PWY-5497", "PWY-5485", "PWY-6637", "PWY-5482"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1281:t:sulfoacetaldehyde degradation I", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-5485:t:pyruvate fermentation to acetate IV", "PWY-6637:t:sulfolactate degradation II", "PWY-5482:t:pyruvate fermentation to acetate II"], "type": "Domain"}, "IPR010767": {"description": "Campylobacter phage CGC-2007, Cje0229", "go_ids": [], "go_terms": [], "name": "Phage_CGC-2007_Cje0229", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010768": {"description": "Putative glutamine amidotransferase", "go_ids": [], "go_terms": [], "name": "GATase1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010769": {"description": "Ribosomal RNA aminoglycoside-resistance methyltransferase, Gram-negative bacteria", "go_ids": ["GO:0008649", "GO:0046677"], "go_terms": ["GO:0008649:rRNA methyltransferase activity:F", "GO:0046677:response to antibiotic:P"], "name": "rRNA_MeTrfase_GmN_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010770": {"description": "Ecd family", "go_ids": [], "go_terms": [], "name": "Ecd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010771": {"description": "Intracellular growth attenuator IgaA", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "IgaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010772": {"description": "Protein of unknown function DUF1359", "go_ids": [], "go_terms": [], "name": "DUF1359", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010773": {"description": "Mycobacterium phage PG1, Gp7", "go_ids": [], "go_terms": [], "name": "Mycophage_PG1_Gp7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010774": {"description": "Putative nuclease YbcO", "go_ids": [], "go_terms": [], "name": "YbcO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010775": {"description": "Protein of unknown function DUF1365", "go_ids": [], "go_terms": [], "name": "DUF1365", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010776": {"description": "Homologous-pairing protein 2, winged helix domain", "go_ids": [], "go_terms": [], "name": "Hop2_WH_dom", "pathway_ids": ["R-HSA-912446"], "pathways": ["R-HSA-912446:r:Meiotic recombination"], "type": "Domain"}, "IPR010777": {"description": "PipA", "go_ids": [], "go_terms": [], "name": "PipA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010778": {"description": "Protein of unknown function DUF1368", "go_ids": [], "go_terms": [], "name": "DUF1368", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010779": {"description": "Protein of unknown function DUF1372", "go_ids": [], "go_terms": [], "name": "DUF1372", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010780": {"description": "Protein of unknown function DUF1375", "go_ids": [], "go_terms": [], "name": "DUF1375", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010781": {"description": "Domain of unknown function DUF1376", "go_ids": [], "go_terms": [], "name": "DUF1376", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010784": {"description": "Merozoite surface protein-type", "go_ids": [], "go_terms": [], "name": "Merozoite_SPAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010785": {"description": "Autographa californica nuclear polyhedrosis virus (AcMNPV), Protein AC18", "go_ids": [], "go_terms": [], "name": "AcMNPV_AC18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010787": {"description": "Protein of unknown function DUF1385", "go_ids": [], "go_terms": [], "name": "DUF1385", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010788": {"description": "VDE lipocalin domain", "go_ids": ["GO:0046422"], "go_terms": ["GO:0046422:violaxanthin de-epoxidase activity:F"], "name": "VDE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010789": {"description": "Terminase small subunit, Skunalikevirus-type", "go_ids": [], "go_terms": [], "name": "Terminase_ssu_Skunalikevirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010790": {"description": "Repeat of unknown function DUF1388", "go_ids": [], "go_terms": [], "name": "DUF1388", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010791": {"description": "AttH domain", "go_ids": [], "go_terms": [], "name": "AttH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010792": {"description": "Protein of unknown function DUF1389", "go_ids": [], "go_terms": [], "name": "DUF1389", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010793": {"description": "Large ribosomal subunit protein mL37/mL65", "go_ids": ["GO:0003735", "GO:0005739", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005739:mitochondrion:C", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_mL37/mL65", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-MMU-5389840", "R-HSA-5389840", "R-BTA-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR010794": {"description": "Maltose operon periplasmic, central domain", "go_ids": ["GO:0008643", "GO:0042597"], "go_terms": ["GO:0008643:carbohydrate transport:P", "GO:0042597:periplasmic space:C"], "name": "MalM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010795": {"description": "Prenylcysteine lyase", "go_ids": ["GO:0016670", "GO:0030328"], "go_terms": ["GO:0016670:oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor:F", "GO:0030328:prenylcysteine catabolic process:P"], "name": "Prenylcys_lyase", "pathway_ids": ["R-HSA-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR010796": {"description": "B9-type C2 domain", "go_ids": [], "go_terms": [], "name": "C2_B9-type_dom", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-DRE-2500257", "R-HSA-5620912", "R-HSA-141444", "R-RNO-5610787", "R-MMU-68877", "R-RNO-5620912", "R-DRE-2467813", "R-RNO-5663220", "R-DRE-141444", "R-HSA-9648025", "R-HSA-68877", "R-HSA-5610787", "R-MMU-5610787", "R-RNO-9648025", "R-RNO-2467813", "R-DRE-5663220", "R-HSA-5663220", "R-MMU-5620912", "R-MMU-9648025", "R-DME-5610787", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-5610787:r:Hedgehog 'off' state", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR010797": {"description": "Peroxisome assembly protein 26", "go_ids": ["GO:0005778", "GO:0045046", "GO:0044877"], "go_terms": ["GO:0005778:peroxisomal membrane:C", "GO:0045046:protein import into peroxisome membrane:P", "GO:0044877:protein-containing complex binding:F"], "name": "Pex26", "pathway_ids": ["R-HSA-9603798", "R-HSA-9033241", "R-MMU-9603798", "R-MMU-9033241"], "pathways": ["R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR010798": {"description": "Triadin", "go_ids": ["GO:0005102", "GO:0016020", "GO:0016529"], "go_terms": ["GO:0005102:signaling receptor binding:F", "GO:0016020:membrane:C", "GO:0016529:sarcoplasmic reticulum:C"], "name": "Triadin", "pathway_ids": ["R-HSA-2672351", "R-MMU-5578775", "R-HSA-5578775", "R-RNO-2672351", "R-MMU-2672351", "R-RNO-5578775"], "pathways": ["R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-RNO-5578775:r:Ion homeostasis"], "type": "Family"}, "IPR010799": {"description": "Microcystin LR degradation protein MlrC, C-terminal", "go_ids": [], "go_terms": [], "name": "MlrC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010800": {"description": "Glycine rich protein", "go_ids": [], "go_terms": [], "name": "GRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010801": {"description": "Fibronectin-attachment", "go_ids": ["GO:0005576", "GO:0050840"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0050840:extracellular matrix binding:F"], "name": "FAP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010802": {"description": "Domain of unknown function DUF1400", "go_ids": [], "go_terms": [], "name": "DUF1400", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010803": {"description": "Citrus tristeza virus P33", "go_ids": [], "go_terms": [], "name": "CTV_P33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010805": {"description": "Kaposi s sarcoma-associated herpesvirus K8", "go_ids": [], "go_terms": [], "name": "KSHV_K8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010806": {"description": "Poxvirus, TNF receptor-II, C-terminal", "go_ids": [], "go_terms": [], "name": "Poxvirus_TNF-rcpt-II_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010807": {"description": "YfgJ-like", "go_ids": [], "go_terms": [], "name": "YfgJ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010808": {"description": "Chemotaxis protein CheA, P2 response regulator-binding", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004673"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F"], "name": "CheA_P2-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010809": {"description": "Flagellar hook-associated protein 2, C-terminal", "go_ids": ["GO:0007155", "GO:0009288"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0009288:bacterial-type flagellum:C"], "name": "FliD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010810": {"description": "Flagellin hook, IN motif", "go_ids": [], "go_terms": [], "name": "Flagellin_hook_IN_motif", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR010811": {"description": "Domain of unknown function DUF1409", "go_ids": [], "go_terms": [], "name": "DUF1409", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010812": {"description": "Hypersensitivity response secretion-like, HrpJ", "go_ids": ["GO:0019867", "GO:0046903"], "go_terms": ["GO:0019867:outer membrane:C", "GO:0046903:secretion:P"], "name": "HrpJ-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010813": {"description": "Protein of unknown function DUF1413", "go_ids": [], "go_terms": [], "name": "DUF1413", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010814": {"description": "Protein of unknown function DUF1416", "go_ids": [], "go_terms": [], "name": "DUF1416", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010815": {"description": "Protein of unknown function DUF1418", "go_ids": [], "go_terms": [], "name": "DUF1418", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010816": {"description": "Heterokaryon incompatibility Het-C", "go_ids": [], "go_terms": [], "name": "Het-C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010817": {"description": "HemY, N-terminal", "go_ids": [], "go_terms": [], "name": "HemY_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010818": {"description": "DUF1420, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF1420_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010819": {"description": "N-acylglucosamine 2-epimerase/Cellobiose 2-epimerase", "go_ids": ["GO:0016853"], "go_terms": ["GO:0016853:isomerase activity:F"], "name": "AGE/CE", "pathway_ids": ["R-SSC-446210", "R-MMU-446210", "R-RNO-446210", "R-HSA-446210"], "pathways": ["R-SSC-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-RNO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine"], "type": "Family"}, "IPR010820": {"description": "UBA-like domain DUF1421", "go_ids": [], "go_terms": [], "name": "DUF1421", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010823": {"description": "Portal protein Gp20", "go_ids": [], "go_terms": [], "name": "Portal_Gp20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010824": {"description": "Protein of unknown function DUF1425", "go_ids": [], "go_terms": [], "name": "DUF1425", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010825": {"description": "Stress-inducible humoral factor Turandot", "go_ids": ["GO:0002376"], "go_terms": ["GO:0002376:immune system process:P"], "name": "Turandot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010826": {"description": "Phlebovirus glycoprotein G1", "go_ids": ["GO:0016020", "GO:0044423"], "go_terms": ["GO:0016020:membrane:C", "GO:0044423:virion component:C"], "name": "Phlebovirus_G1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010827": {"description": "POTRA domain, BamA/TamA-like", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "BamA/TamA_POTRA", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR010828": {"description": "Alcohol acetyltransferase/N-acetyltransferase-like", "go_ids": [], "go_terms": [], "name": "Atf2/Sli1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010829": {"description": "Eliciting plant response-like/Cerato-platanin", "go_ids": [], "go_terms": [], "name": "ELP/CP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010831": {"description": "Interleukin-23 alpha", "go_ids": ["GO:0006955", "GO:0005125", "GO:0005576"], "go_terms": ["GO:0006955:immune response:P", "GO:0005125:cytokine activity:F", "GO:0005576:extracellular region:C"], "name": "IL-23_alpha", "pathway_ids": ["R-SSC-9020933", "R-MMU-9020933", "R-HSA-9020933", "R-RNO-9020933", "R-HSA-6785807"], "pathways": ["R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020933:r:Interleukin-23 signaling", "R-HSA-9020933:r:Interleukin-23 signaling", "R-RNO-9020933:r:Interleukin-23 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling"], "type": "Family"}, "IPR010832": {"description": "ProSAAS", "go_ids": ["GO:0016486", "GO:0001540", "GO:0140776", "GO:0098754", "GO:0050877", "GO:0010951", "GO:0004866"], "go_terms": ["GO:0016486:peptide hormone processing:P", "GO:0001540:amyloid-beta binding:F", "GO:0140776:protein-containing complex destabilizing activity:F", "GO:0098754:detoxification:P", "GO:0050877:nervous system process:P", "GO:0010951:negative regulation of endopeptidase activity:P", "GO:0004866:endopeptidase inhibitor activity:F"], "name": "ProSAAS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010835": {"description": "Protein of unknown function DUF1439", "go_ids": [], "go_terms": [], "name": "DUF1439", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010836": {"description": "SapC", "go_ids": [], "go_terms": [], "name": "SapC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010837": {"description": "Conjugal transfer, TrbH", "go_ids": [], "go_terms": [], "name": "Conjugal_tfr_TrbH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010838": {"description": "Protein of unknown unction DUF1444", "go_ids": [], "go_terms": [], "name": "DUF1444", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010839": {"description": "Acyclic terpene utilisation, N-terminal", "go_ids": [], "go_terms": [], "name": "AtuA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010840": {"description": "Inner membrane protein YqiJ, OB-fold domain", "go_ids": [], "go_terms": [], "name": "YqiJ_OB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010841": {"description": "Elongation factor G-binding protein, N-terminal", "go_ids": [], "go_terms": [], "name": "EF-G-binding_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010843": {"description": "Uncharacterised protein family AroM", "go_ids": [], "go_terms": [], "name": "Uncharacterised_AroM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010844": {"description": "Occludin homology domain", "go_ids": [], "go_terms": [], "name": "Occludin_ELL", "pathway_ids": ["R-MMU-6796648", "R-HSA-6807505", "R-HSA-6781827", "R-HSA-167238", "R-RNO-6807505", "R-HSA-167243", "R-DME-674695", "R-RNO-351906", "R-DME-6796648", "R-MMU-351906", "R-HSA-6796648", "R-HSA-351906", "R-DME-75955", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-MMU-6807505", "R-DME-351906", "R-HSA-167287", "R-DME-6807505", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-8935964", "R-HSA-75955", "R-HSA-167152", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR010845": {"description": "Flagellar FlaF", "go_ids": ["GO:0044781"], "go_terms": ["GO:0044781:bacterial-type flagellum organization:P"], "name": "FlaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010846": {"description": "N-acetylmuramoyl-L-alanine amidase-like", "go_ids": [], "go_terms": [], "name": "AmiA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010848": {"description": "Protein of unknown function DUF1465", "go_ids": [], "go_terms": [], "name": "DUF1465", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010849": {"description": "Gonadal family", "go_ids": [], "go_terms": [], "name": "Gonadal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010850": {"description": "Neuroparsin", "go_ids": [], "go_terms": [], "name": "Neuroparsin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010851": {"description": "Defensin-like protein", "go_ids": [], "go_terms": [], "name": "DEFL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010852": {"description": "Putative stress-induced transcription regulator", "go_ids": [], "go_terms": [], "name": "ABATE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010853": {"description": "DC-EC", "go_ids": [], "go_terms": [], "name": "CagY_M", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010854": {"description": "YdgH/BhsA/McbA-like domain", "go_ids": [], "go_terms": [], "name": "YdgH/BhsA/McbA-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010855": {"description": "Cytomegalovirus IE1/IE2", "go_ids": ["GO:0039695"], "go_terms": ["GO:0039695:DNA-templated viral transcription:P"], "name": "Cytomega_IE1/IE2", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR010856": {"description": "Gig2-like", "go_ids": [], "go_terms": [], "name": "Gig2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010857": {"description": "Zona-pellucida-binding", "go_ids": ["GO:0005576", "GO:0007339"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0007339:binding of sperm to zona pellucida:P"], "name": "Sp38-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010858": {"description": "Protein of unknown function DUF1481", "go_ids": [], "go_terms": [], "name": "DUF1481", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010860": {"description": "CAMP factor", "go_ids": [], "go_terms": [], "name": "CAMP_factor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010861": {"description": "Protein of unknown function DUF1492", "go_ids": [], "go_terms": [], "name": "DUF1492", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010862": {"description": "Protein of unknown function DUF1493", "go_ids": [], "go_terms": [], "name": "DUF1493", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010863": {"description": "Regulator EarA-like", "go_ids": [], "go_terms": [], "name": "EarA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010864": {"description": "D-lyxose isomerase", "go_ids": [], "go_terms": [], "name": "D-lyxose_isomer", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010865": {"description": "Protein of unknown function DUF1499", "go_ids": [], "go_terms": [], "name": "DUF1499", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010866": {"description": "Alpha-2,8-polysialyltransferase", "go_ids": [], "go_terms": [], "name": "A-2_8-polyST", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010867": {"description": "NPR nonapeptide", "go_ids": [], "go_terms": [], "name": "NPR_nonapeptide", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010868": {"description": "Tumor suppressor ARF", "go_ids": ["GO:0051726", "GO:0006915", "GO:0008285"], "go_terms": ["GO:0051726:regulation of cell cycle:P", "GO:0006915:apoptotic process:P", "GO:0008285:negative regulation of cell population proliferation:P"], "name": "Tumor_suppres_ARF", "pathway_ids": ["R-HSA-3108214", "R-HSA-2559580", "R-HSA-6804757", "R-HSA-9645722", "R-HSA-8941858", "R-HSA-2559585", "R-HSA-9646304", "R-HSA-3232118", "R-HSA-69541", "R-HSA-9759194", "R-HSA-9646303", "R-HSA-111471"], "pathways": ["R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-9645722:r:Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-9646304:r:Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-HSA-69541:r:Stabilization of p53", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9646303:r:Evasion of Oncogene Induced Senescence Due to p14ARF Defects", "R-HSA-111471:r:Apoptotic factor-mediated response"], "type": "Family"}, "IPR010869": {"description": "Protein of unknown function DUF1501", "go_ids": [], "go_terms": [], "name": "DUF1501", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010870": {"description": "Phosphate-selective porin O/P", "go_ids": [], "go_terms": [], "name": "Porin_O/P", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010871": {"description": "Protein of unknown function DUF1502", "go_ids": [], "go_terms": [], "name": "DUF1502", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR010872": {"description": "MDMPI C-terminal", "go_ids": [], "go_terms": [], "name": "MDMPI_C-term_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010874": {"description": "Telomere-binding protein subunit beta", "go_ids": ["GO:0000781", "GO:0042162"], "go_terms": ["GO:0000781:chromosome, telomeric region:C", "GO:0042162:telomeric repeat DNA binding:F"], "name": "TEBB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010875": {"description": "Protein of unknown function DUF1506", "go_ids": [], "go_terms": [], "name": "DUF1506", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010876": {"description": "Lipid transport auxiliary protein 1", "go_ids": [], "go_terms": [], "name": "LTAP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010877": {"description": "Bacteriophage Mu, Baseplate protein gp46", "go_ids": [], "go_terms": [], "name": "Phage_Mu_Gp46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010878": {"description": "Protein of unknown function Gp111", "go_ids": [], "go_terms": [], "name": "Gp111", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010879": {"description": "Domain of unknown function DUF1508", "go_ids": [], "go_terms": [], "name": "DUF1508", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010880": {"description": "Herpesvirus UL37, HHV-5-related", "go_ids": [], "go_terms": [], "name": "Herpes_UL37_HHV-5-rel", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR010881": {"description": "Gammaherpesvirus latent membrane protein 2", "go_ids": ["GO:0033644", "GO:0019042"], "go_terms": ["GO:0033644:host cell membrane:C", "GO:0019042:viral latency:P"], "name": "Herpes_LMP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010882": {"description": "Acidic phosphoprotein PCEMA1", "go_ids": [], "go_terms": [], "name": "PCEMA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010883": {"description": "Marek disease virus, LORF3", "go_ids": [], "go_terms": [], "name": "Marek_disease_virus_LORF3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010884": {"description": "6-Cysteine (6-Cys) domain", "go_ids": [], "go_terms": [], "name": "6_CYS_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010886": {"description": "Histone H1-like Hc1", "go_ids": ["GO:0003677", "GO:0030527"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0030527:structural constituent of chromatin:F"], "name": "Hc1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010888": {"description": "CFA/I fimbrial subunit E, C-terminal", "go_ids": [], "go_terms": [], "name": "CfaE_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010889": {"description": "Protein of unknown function DUF1515", "go_ids": [], "go_terms": [], "name": "DUF1515", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010890": {"description": "PriC", "go_ids": [], "go_terms": [], "name": "PriC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010892": {"description": "Secreted phosphoprotein 24", "go_ids": ["GO:0005576", "GO:0046849"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0046849:bone remodeling:P"], "name": "Spp-24", "pathway_ids": ["R-BTA-8957275", "R-RNO-381426", "R-HSA-114608", "R-BTA-114608", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins 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"Domain"}, "IPR010896": {"description": "Nuclease-associated modular DNA-binding 1", "go_ids": [], "go_terms": [], "name": "NUMOD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010897": {"description": "Sporulation stage II, protein P", "go_ids": [], "go_terms": [], "name": "Spore_II_P", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010898": {"description": "Heptaprenyl diphosphate synthase component I", "go_ids": [], "go_terms": [], "name": "Hpre_diP_synth_I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010899": {"description": "Protein of unknown function UPF0344", "go_ids": [], "go_terms": [], "name": "UPF0344", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010900": {"description": "Nicotine adenine dinucleotide glycohydrolase, catalytic domain", "go_ids": [], "go_terms": [], "name": "NA_dinucl_GlycHdrlase_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010901": {"description": "Merozoite surface 1, C-terminal", 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"R-XTR-9013148", "R-RNO-199992", "R-RNO-9013423", "R-HSA-204005", "R-BTA-9013408", "R-HSA-9013149", "R-XTR-8980692", "R-DRE-6811438", "R-HSA-8980692", "R-SPO-6811438", "R-DRE-9013148", "R-MMU-9013423", "R-HSA-8856825", "R-SCE-6811438", "R-HSA-1236974", "R-BTA-8980692", "R-DRE-8980692", "R-BTA-6811438", "R-MMU-9013149"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9020591:r:Interleukin-12 signaling", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-XTR-6811438:r:Intra-Golgi traffic", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9020591:r:Interleukin-12 signaling", "R-XTR-204005:r:COPII-mediated vesicle transport", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-DRE-9013408:r:RHOG GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-XTR-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-XTR-9013408:r:RHOG GTPase cycle", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-RNO-199992:r:trans-Golgi Network Vesicle Budding", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-XTR-8980692:r:RHOA GTPase cycle", "R-DRE-6811438:r:Intra-Golgi traffic", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SPO-6811438:r:Intra-Golgi traffic", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-6811438:r:Intra-Golgi traffic", "R-HSA-1236974:r:ER-Phagosome pathway", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-BTA-6811438:r:Intra-Golgi traffic", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR010909": {"description": "PLAC", "go_ids": [], "go_terms": [], "name": "PLAC", "pathway_ids": ["R-HSA-1474228", "R-HSA-6809371", "R-HSA-8963889", "R-HSA-5083635", "R-BTA-5173214", "R-HSA-1650814", "R-RNO-5173214", "R-HSA-1181150", "R-HSA-5173214", "R-HSA-9768727", "R-MMU-1650814", "R-MMU-5173214", "R-HSA-167060", "R-RNO-167060", "R-RNO-8963889", "R-RNO-9768727", "R-BTA-1650814"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-1181150:r:Signaling by NODAL", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-167060:r:NGF processing", "R-RNO-167060:r:NGF processing", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes"], "type": "Domain"}, "IPR010914": {"description": "RsgA GTPase domain", "go_ids": ["GO:0003924", "GO:0005525"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005525:GTP binding:F"], "name": "RsgA_GTPase_dom", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR010915": {"description": "Polyhydroxyalkanoate depolymerase", "go_ids": [], "go_terms": [], "name": "PHB_depoly_PhaZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010918": {"description": "PurM-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PurM-like_C_dom", "pathway_ids": ["R-SSC-2408557", "R-SPO-73817", "R-HSA-2408557", "R-DDI-73817", "R-MMU-2408557", "R-DME-73817", "R-DRE-2408557", "R-DME-2408557", "R-DDI-2408557", "R-CEL-2408557", "R-SCE-73817", "R-BTA-73817", "R-CEL-73817", "R-HSA-73817", "R-MMU-73817", "R-GGA-419140"], "pathways": ["R-SSC-2408557:r:Selenocysteine synthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-2408557:r:Selenocysteine synthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-2408557:r:Selenocysteine synthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DRE-2408557:r:Selenocysteine synthesis", "R-DME-2408557:r:Selenocysteine synthesis", "R-DDI-2408557:r:Selenocysteine synthesis", "R-CEL-2408557:r:Selenocysteine synthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Domain"}, "IPR010919": {"description": "SAND-like domain superfamily", "go_ids": [], "go_terms": [], "name": "SAND-like_dom_sf", "pathway_ids": ["R-MMU-2173795", "R-HSA-201451", "R-MMU-201451", "R-HSA-877300", "R-HSA-3108214", "R-HSA-2173795"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-201451:r:Signaling by BMP", "R-MMU-201451:r:Signaling by BMP", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "type": "Homologous_superfamily"}, "IPR010920": {"description": "LSM domain superfamily", "go_ids": [], "go_terms": [], "name": "LSM_dom_sf", "pathway_ids": ["R-MMU-77588", "R-CEL-72165", "R-MMU-9770562", "R-GGA-73856", "R-HSA-73856", "R-DME-72163", "R-RNO-72163", "R-DDI-72163", "R-RNO-73856", "R-BTA-430039", "R-RNO-191859", "R-MMU-430039", "R-RNO-72165", "R-CEL-9770562", "R-DME-73856", "R-HSA-430039", "R-SPO-430039", "R-BTA-72163", "R-MMU-72163", "R-MMU-73856", "R-BTA-73856", "R-GGA-111367", "R-SPO-9770562", "R-HSA-72163", "R-DME-72165", "R-MMU-111367", "R-BTA-9770562", "R-DME-77588", "R-GGA-191859", "R-CEL-77588", "R-DME-111367", "R-GGA-77588", "R-BTA-191859", "R-CEL-111367", "R-HSA-191859", "R-CEL-191859", "R-BTA-77588", "R-DDI-9770562", "R-CEL-73856", "R-DDI-111367", "R-HSA-6811440", "R-DRE-191859", "R-DME-9770562", "R-DDI-73856", "R-DRE-72163", "R-GGA-72163", "R-DRE-9770562", "R-HSA-77588", "R-HSA-111367", "R-HSA-72165", "R-GGA-9770562", "R-CEL-72163", "R-CEL-430039", "R-HSA-9918481", "R-MMU-191859", "R-DDI-430039", "R-BTA-111367", "R-GGA-72165", "R-HSA-9770562", "R-BTA-72165", "R-SCE-430039", "R-HSA-9754678", "R-RNO-111367", "R-MMU-72165", "R-DDI-77588", "R-DRE-430039", "R-RNO-9770562", "R-RNO-77588", "R-SPO-72163", "R-DRE-72165"], "pathways": ["R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-191859:r:snRNP Assembly", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SPO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-GGA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-BTA-9770562:r:mRNA Polyadenylation", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-GGA-191859:r:snRNP Assembly", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DME-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-GGA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-BTA-191859:r:snRNP Assembly", "R-CEL-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-191859:r:snRNP Assembly", "R-CEL-191859:r:snRNP Assembly", "R-BTA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DRE-191859:r:snRNP Assembly", "R-DME-9770562:r:mRNA Polyadenylation", "R-DDI-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-GGA-9770562:r:mRNA Polyadenylation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-191859:r:snRNP Assembly", "R-DDI-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-BTA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-GGA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-RNO-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-9770562:r:mRNA Polyadenylation", "R-RNO-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DRE-72165:r:mRNA Splicing - Minor Pathway"], "type": "Homologous_superfamily"}, "IPR010921": {"description": "Trp repressor/replication initiator", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "Trp_repressor/repl_initiator", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR010923": {"description": "tRNA threonylcarbamoyladenosine biosynthesis protein SUA5", "go_ids": [], "go_terms": [], "name": "T(6)A37_SUA5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010924": {"description": "DNA-directed RNA polymerase subunit Rpo4", "go_ids": [], "go_terms": [], "name": "Rpo4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010926": {"description": "Class I myosin tail homology domain", "go_ids": ["GO:0003774", "GO:0016459"], "go_terms": ["GO:0003774:cytoskeletal motor activity:F", "GO:0016459:myosin complex:C"], "name": "Myosin_TH1", "pathway_ids": ["R-MMU-5250924", "R-HSA-9662360", "R-HSA-1445148", "R-HSA-9662361", "R-HSA-5250924", "R-BTA-5250924", "R-HSA-2029482", "R-RNO-5250924", "R-HSA-9664422", "R-MMU-2029482", "R-RNO-2029482"], "pathways": ["R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation"], "type": "Domain"}, "IPR010927": {"description": "Type IV conjugative transfer system protein TraH", "go_ids": [], "go_terms": [], "name": "T4SS_TraH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010928": {"description": "Tyrosinase co-factor MelC1", "go_ids": ["GO:0005507", "GO:0042438"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0042438:melanin biosynthetic process:P"], "name": "MelC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010929": {"description": "CDR ABC transporter", "go_ids": ["GO:0005524", "GO:0016020", "GO:0042626", "GO:0055085"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016020:membrane:C", "GO:0042626:ATPase-coupled transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P"], "name": "PDR_CDR_ABC", "pathway_ids": ["R-DDI-1369062", "R-DDI-1660661", "R-DDI-917937", "R-DDI-189483", "R-DDI-9793528", "R-DDI-8964058", "R-DDI-9753281", "R-DDI-189451"], "pathways": ["R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-189483:r:Heme degradation", "R-DDI-9793528:r:Ciprofloxacin ADME", "R-DDI-8964058:r:HDL remodeling", "R-DDI-9753281:r:Paracetamol ADME", "R-DDI-189451:r:Heme biosynthesis"], "type": "Domain"}, "IPR010930": {"description": "Flagellar basal-body/hook protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Flg_bb/hook_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010931": {"description": "RepB-like, C-terminal domain, bacillales", "go_ids": [], "go_terms": [], "name": "RepB_C_bacillales", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010932": {"description": "Large T antigen, polyomavirus, C-terminal", "go_ids": ["GO:0003677", "GO:0005524", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F", "GO:0006260:DNA replication:P"], "name": "Lg_T_Ag_Polyomavir_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010933": {"description": "NADH dehydrogenase subunit 2, C-terminal", "go_ids": ["GO:0006120", "GO:0008137"], "go_terms": ["GO:0006120:mitochondrial electron transport, NADH to ubiquinone:P", "GO:0008137:NADH dehydrogenase (ubiquinone) activity:F"], "name": "NADH_DH_su2_C", "pathway_ids": ["PWY-4302", "PWY-6692", "PWY-3781", "PWY-5083", "R-HSA-5419276", "R-SSC-5419276", "R-HSA-6799198", "R-MMU-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DRE-611105", "R-SSC-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-RNO-5419276", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9837999", "R-SSC-611105", "R-DRE-5419276"], "pathways": ["PWY-4302:t:aerobic respiration III (alternative oxidase pathway)", "PWY-6692:t:Fe(II) oxidation", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-5083:t:NAD(P)/NADPH interconversion", "R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-SSC-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Domain"}, "IPR010934": {"description": "NADH dehydrogenase subunit 5, C-terminal", "go_ids": [], "go_terms": [], "name": "NADH_DH_su5_C", "pathway_ids": ["PWY-4302", "PWY-6692", "PWY-3781", "PWY-5083", "R-HSA-5419276", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-DRE-611105", "R-RNO-6799198", "R-SSC-5419276", "R-SSC-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-RNO-5419276", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9837999", "R-SSC-611105", "R-DRE-5419276"], "pathways": ["PWY-4302:t:aerobic respiration III (alternative oxidase pathway)", "PWY-6692:t:Fe(II) oxidation", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-5083:t:NAD(P)/NADPH interconversion", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-RNO-6799198:r:Complex I biogenesis", "R-SSC-5419276:r:Mitochondrial translation termination", "R-SSC-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Domain"}, "IPR010935": {"description": "SMCs flexible hinge", "go_ids": ["GO:0005515", "GO:0005524", "GO:0005694", "GO:0051276"], "go_terms": ["GO:0005515:protein binding:F", "GO:0005524:ATP binding:F", "GO:0005694:chromosome:C", "GO:0051276:chromosome organization:P"], "name": "SMC_hinge", "pathway_ids": ["R-SCE-3108214", "R-HSA-2468052", "R-SPO-2470946", "R-BTA-2468052", "R-HSA-2467813", "R-HSA-3108214", "R-RNO-2500257", "R-MMU-2467813", "R-RNO-2470946", "R-HSA-2514853", "R-BTA-3108214", "R-RNO-3108214", "R-HSA-1221632", "R-CEL-2299718", "R-BTA-2467813", "R-DDI-2468052", "R-CEL-3108214", "R-BTA-2500257", "R-RNO-2468052", "R-HSA-2299718", "R-SCE-2514853", "R-HSA-9018519", "R-DDI-2470946", "R-CEL-2500257", "R-BTA-2470946", "R-SPO-2500257", "R-SCE-2468052", "R-MMU-2500257", "R-SPO-3108214", "R-HSA-2500257", "R-SPO-2514853", "R-CEL-2470946", "R-HSA-2470946", "R-DDI-2514853", "R-MMU-2514853", "R-DDI-2500257", "R-SCE-2500257", "R-DDI-2299718", "R-MMU-2299718", "R-RNO-2467813", "R-MMU-3108214", "R-CEL-2468052", "R-DDI-3108214", "R-MMU-2468052", "R-MMU-2470946"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-BTA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1221632:r:Meiotic synapsis", "R-CEL-2299718:r:Condensation of Prophase Chromosomes", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-DDI-2468052:r:Establishment of Sister Chromatid Cohesion", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DDI-2470946:r:Cohesin Loading onto Chromatin", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-2470946:r:Cohesin Loading onto Chromatin", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-DDI-2514853:r:Condensation of Prometaphase Chromosomes", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DDI-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin"], "type": "Domain"}, "IPR010938": {"description": "Protein of unknown function DUF1131", "go_ids": [], "go_terms": [], "name": "DUF1131", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010940": {"description": "Magnesium-protoporphyrin IX methyltransferase, C-terminal", "go_ids": ["GO:0015995", "GO:0046406"], "go_terms": ["GO:0015995:chlorophyll biosynthetic process:P", "GO:0046406:magnesium protoporphyrin IX methyltransferase activity:F"], "name": "Mg_prot_MeTrfase_C", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Domain"}, "IPR010941": {"description": "Poly-beta-hydroxybutyrate polymerase, N-terminal domain", "go_ids": ["GO:0042619"], "go_terms": ["GO:0042619:poly-hydroxybutyrate biosynthetic process:P"], "name": "PhaC_N", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR010943": {"description": "Xanthosine phosphorylase", "go_ids": ["GO:0055086", "GO:0004731", "GO:0005737"], "go_terms": ["GO:0055086:nucleobase-containing small molecule metabolic process:P", "GO:0004731:purine-nucleoside phosphorylase activity:F", "GO:0005737:cytoplasm:C"], "name": "Xanthosine_phosphorylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010944": {"description": "AMP nucleosidase, putative", "go_ids": [], "go_terms": [], "name": "AMN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010945": {"description": "Malate dehydrogenase, type 2", "go_ids": ["GO:0006108", "GO:0016615"], "go_terms": ["GO:0006108:malate metabolic process:P", "GO:0016615:malate dehydrogenase activity:F"], "name": "Malate_DH_type2", "pathway_ids": ["PWY-7383", "PWY-8086", "PWY-1622", "PWY-6728", "PWY-7115", "PWY-561", "PWY-5690", "PWY-5392", "PWY-6969", "R-DDI-9856872", "R-HSA-9856872", "R-SSC-9856872", "R-MMU-9856872", "R-XTR-9856872", "R-RNO-9856872", "R-GGA-352875", "R-CEL-9856872", "R-BTA-9856872"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-6728:t:methylaspartate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "R-DDI-9856872:r:Malate-aspartate shuttle", "R-HSA-9856872:r:Malate-aspartate shuttle", "R-SSC-9856872:r:Malate-aspartate shuttle", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-XTR-9856872:r:Malate-aspartate shuttle", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-GGA-352875:r:Gluconeogenesis", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-BTA-9856872:r:Malate-aspartate shuttle"], "type": "Family"}, "IPR010946": {"description": "Geranylgeranylglyceryl phosphate synthase", "go_ids": ["GO:0000287", "GO:0005737", "GO:0006650", "GO:0047294"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0005737:cytoplasm:C", "GO:0006650:glycerophospholipid metabolic process:P", "GO:0047294:phosphoglycerol geranylgeranyltransferase activity:F"], "name": "GGGP_synth", "pathway_ids": ["PWY-6349"], "pathways": ["PWY-6349:t:C20,20 CDP-archaeol biosynthesis"], "type": "Family"}, "IPR010948": {"description": "TonB-dependent lactoferrin/transferrin receptor", "go_ids": ["GO:0019867", "GO:0006826", "GO:0015091"], "go_terms": ["GO:0019867:outer membrane:C", "GO:0006826:iron ion transport:P", "GO:0015091:ferric iron transmembrane transporter activity:F"], "name": "TonB_lacto/transferrin_rcpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010949": {"description": "TonB-dependent haemoglobin/transferrin/lactoferrin receptor", "go_ids": ["GO:0019867", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0019867:outer membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "TonB_Hb/transfer/lactofer_rcpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010950": {"description": "Chorismate mutase, archaeal", "go_ids": [], "go_terms": [], "name": "Chorismate_mutase_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010951": {"description": "Chorismate mutase, bacteria", "go_ids": [], "go_terms": [], "name": "CM_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010952": {"description": "Chorismate mutase, gammaproteobacteria", "go_ids": ["GO:0004106", "GO:0005737", "GO:0009094"], "go_terms": ["GO:0004106:chorismate mutase activity:F", "GO:0005737:cytoplasm:C", "GO:0009094:L-phenylalanine biosynthetic process:P"], "name": "CM_P_1", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627", "PWY-7432"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7432:t:L-phenylalanine biosynthesis III (cytosolic, plants)"], "type": "Domain"}, "IPR010953": {"description": "Citrate synthase, type I", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "Citrate_synthase_typ-I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010954": {"description": "Chorismate mutase, Firmicutes/Deinococcus", "go_ids": [], "go_terms": [], "name": "Chorismate_mutase_GmP-bac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010957": {"description": "Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain", "go_ids": ["GO:0004106", "GO:0005737", "GO:0009094"], "go_terms": ["GO:0004106:chorismate mutase activity:F", "GO:0005737:cytoplasm:C", "GO:0009094:L-phenylalanine biosynthetic process:P"], "name": "G/b/e-P-prot_chorismate_mutase", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627", "PWY-7432"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7432:t:L-phenylalanine biosynthesis III (cytosolic, plants)"], "type": "Domain"}, "IPR010958": {"description": "Chorismate mutase, high GC Gram-positive bacteria/archaeal", "go_ids": [], "go_terms": [], "name": "Chorismate_mutase_highGC-bac", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis"], "type": "Domain"}, "IPR010960": {"description": "Flavocytochrome c", "go_ids": ["GO:0016491", "GO:0010181"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0010181:FMN binding:F"], "name": "Flavocytochrome_c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010961": {"description": "Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase", "go_ids": ["GO:0003870", "GO:0030170", "GO:0033014"], "go_terms": ["GO:0003870:5-aminolevulinate synthase activity:F", "GO:0030170:pyridoxal phosphate binding:F", "GO:0033014:tetrapyrrole biosynthetic process:P"], "name": "4pyrrol_synth_NH2levulA_synth", "pathway_ids": ["PWY-5189", "PWY-7536", "R-HSA-1989781", "R-RNO-189451", "R-MMU-9837999", "R-HSA-2151201", "R-DRE-189451", "R-MMU-189451", "R-GGA-421984", "R-HSA-9837999", "R-RNO-9837999", "R-BTA-189451", "R-SPO-189451", "R-SCE-189451", "R-HSA-189451"], "pathways": ["PWY-5189:t:tetrapyrrole biosynthesis II (from glycine)", "PWY-7536:t:2-amino-3-hydroxycyclopent-2-enone biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-189451:r:Heme biosynthesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DRE-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-GGA-421984:r:Heme synthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Domain"}, "IPR010962": {"description": "Putative 8-amino-7-oxononanoate synthase, Archaea/Firmicutes type", "go_ids": [], "go_terms": [], "name": "AONS_Archaea/Firmicutes", "pathway_ids": ["PWY-6578", "PWY-6519", "PWY-8203", "PWY-7147"], "pathways": ["PWY-6578:t:8-amino-7-oxononanoate biosynthesis III", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7147:t:8-amino-7-oxononanoate biosynthesis II"], "type": "Family"}, "IPR010963": {"description": "Poly(R)-hydroxyalkanoic acid synthase, class I", "go_ids": ["GO:0005737", "GO:0016746", "GO:0042619"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0016746:acyltransferase activity:F", "GO:0042619:poly-hydroxybutyrate biosynthetic process:P"], "name": "PHA_synth_I", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR010964": {"description": "Peptidase M20A, peptidase V-related", "go_ids": ["GO:0008270", "GO:0016805"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0016805:dipeptidase activity:F"], "name": "M20A_pepV-rel", "pathway_ids": ["PWY-6842", "PWY-7569", "PWY-7570"], "pathways": ["PWY-6842:t:glutathione-mediated detoxification II", "PWY-7569:t:arginomycin biosynthesis", "PWY-7570:t:blasticidin S biosynthesis"], "type": "Family"}, "IPR010965": {"description": "HesB-related, selonoprotein", "go_ids": [], "go_terms": [], "name": "HesB-rel_seleno", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010966": {"description": "Na(+)-translocating NADH-quinone reductase subunit B", "go_ids": ["GO:0010181", "GO:0016020", "GO:0016655", "GO:0022904"], "go_terms": ["GO:0010181:FMN binding:F", "GO:0016020:membrane:C", "GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F", "GO:0022904:respiratory electron transport chain:P"], "name": "NqrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010967": {"description": "Na(+)-translocating NADH-quinone reductase subunit E", "go_ids": ["GO:0009276", "GO:0016020", "GO:0016655", "GO:0022904"], "go_terms": ["GO:0009276:Gram-negative-bacterium-type cell wall:C", "GO:0016020:membrane:C", "GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F", "GO:0022904:respiratory electron transport chain:P"], "name": "NqrE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010968": {"description": "Ion-translocating oxidoreductase complex subunit E", "go_ids": ["GO:0016020", "GO:0022900"], "go_terms": ["GO:0016020:membrane:C", "GO:0022900:electron transport chain:P"], "name": "RnfE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010969": {"description": "Cysteine desulfurase-related, unknown function", "go_ids": [], "go_terms": [], "name": "Cys_dSase-rel_unknwn_funct", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR010970": {"description": "Cysteine desulfurase, SufS", "go_ids": ["GO:0019448", "GO:0030170", "GO:0031071"], "go_terms": ["GO:0019448:L-cysteine catabolic process:P", "GO:0030170:pyridoxal phosphate binding:F", "GO:0031071:cysteine desulfurase activity:F"], "name": "Cys_dSase_SufS", "pathway_ids": ["PWY-6892", "PWY-8165", "PWY-6823", "PWY-8452", "PWY-7250", "PWY-7892", "PWY-8164"], "pathways": ["PWY-6892:t:thiazole component of thiamine diphosphate biosynthesis I", "PWY-8165:t:cytidylyl molybdenum cofactor sulfurylation", "PWY-6823:t:molybdopterin biosynthesis", "PWY-8452:t:L-cysteine degradation IV", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-8164:t:bis(guanylyl molybdopterin) cofactor sulfurylation"], "type": "Family"}, "IPR010971": {"description": "Ubiquinone biosynthesis hydroxylase UbiH/COQ6", "go_ids": ["GO:0006744", "GO:0050660", "GO:0016705"], "go_terms": ["GO:0006744:ubiquinone biosynthetic process:P", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F"], "name": "UbiH/COQ6", "pathway_ids": ["R-DRE-2142789", "R-SCE-2142789", "R-SPO-2142789", "R-MMU-2142789", "R-DDI-2142789", "R-HSA-2142789", "R-BTA-2142789", "R-RNO-2142789", "R-CEL-2142789", "R-DME-2142789"], "pathways": ["R-DRE-2142789:r:Ubiquinol biosynthesis", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-BTA-2142789:r:Ubiquinol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-CEL-2142789:r:Ubiquinol biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis"], "type": "Family"}, "IPR010972": {"description": "Beta-phosphoglucomutase", "go_ids": ["GO:0008801", "GO:0005975", "GO:0000287"], "go_terms": ["GO:0008801:beta-phosphoglucomutase activity:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0000287:magnesium ion binding:F"], "name": "Beta-PGM", "pathway_ids": ["PWY-2721", "PWY-2722", "PWY-7459"], "pathways": ["PWY-2721:t:trehalose degradation III", "PWY-2722:t:trehalose degradation IV", "PWY-7459:t:kojibiose degradation"], "type": "Family"}, "IPR010973": {"description": "Phosphotransferase system, sucrose-specific IIBC component", "go_ids": ["GO:0016020", "GO:0008982", "GO:0009401"], "go_terms": ["GO:0016020:membrane:C", "GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PTS_IIBC_sucr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010974": {"description": "Phosphotransferase system, N-acetylglucosamine-specific IIBC component", "go_ids": ["GO:0008982", "GO:0009401", "GO:0016020", "GO:0019866", "GO:0015572"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C", "GO:0019866:organelle inner membrane:C", "GO:0015572:N-acetylglucosamine transmembrane transporter activity:F"], "name": "PTS_IIBC_nag", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR010975": {"description": "Phosphotransferase system, alpha-glucoside-specific IIBC component", "go_ids": ["GO:0008982", "GO:0009401"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PTS_IIBC_a_glc", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR010976": {"description": "Beta-phosphoglucomutase hydrolase", "go_ids": [], "go_terms": [], "name": "B-phosphoglucomutase_hydrolase", "pathway_ids": ["PWY-2721", "PWY-2722", "PWY-7459"], "pathways": ["PWY-2721:t:trehalose degradation III", "PWY-2722:t:trehalose degradation IV", "PWY-7459:t:kojibiose degradation"], "type": "Domain"}, "IPR010977": {"description": "Aromatic-L-amino-acid decarboxylase", "go_ids": ["GO:0006520", "GO:0016831"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0016831:carboxy-lyase activity:F"], "name": "Aromatic_deC", "pathway_ids": ["R-RNO-70921", "R-HSA-209931", "R-RNO-209905", "R-BTA-70921", "R-DME-70921", "R-DME-209931", "R-MMU-209905", "R-MMU-70921", "R-DME-209905", "R-HSA-209905", "R-RNO-209931", "R-MMU-209931", "R-HSA-70921"], "pathways": ["R-RNO-70921:r:Histidine catabolism", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-RNO-209905:r:Catecholamine biosynthesis", "R-BTA-70921:r:Histidine catabolism", "R-DME-70921:r:Histidine catabolism", "R-DME-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-209905:r:Catecholamine biosynthesis", "R-MMU-70921:r:Histidine catabolism", "R-DME-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-209931:r:Serotonin and melatonin biosynthesis", "R-HSA-70921:r:Histidine catabolism"], "type": "Family"}, "IPR010978": {"description": "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm", "go_ids": ["GO:0000166"], "go_terms": ["GO:0000166:nucleotide binding:F"], "name": "tRNA-bd_arm", "pathway_ids": ["R-HSA-379716", "R-HSA-379726", "R-HSA-2408557"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-2408557:r:Selenocysteine synthesis"], "type": "Homologous_superfamily"}, "IPR010979": {"description": "Small ribosomal subunit protein uS13-like, H2TH", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "Ribosomal_uS13-like_H2TH", "pathway_ids": ["R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553", "R-CFA-1799339", "R-SPO-975957", "R-CFA-72695", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-HSA-72695", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-BTA-72689", "R-MMU-110331", "R-MMU-9954716", "R-CFA-72702", "R-HSA-110331", "R-RNO-9954716", "R-SCE-6791226", "R-CFA-72706", "R-DDI-9954714", "R-HSA-9616334", "R-BTA-72695", "R-SCE-72702", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-DRE-9954714", "R-SCE-975956", "R-SSC-9954714", "R-DDI-72695", "R-DRE-72695", "R-MMU-110330", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-SSC-1799339", "R-RNO-72649", "R-RNO-6791226", "R-CFA-156827", "R-DRE-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-DDI-156827", "R-SSC-72689", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-MMU-110328", "R-SPO-72689", "R-DDI-72702", "R-MMU-1799339", "R-CFA-9954714", "R-BTA-5649702", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DDI-72689", "R-CFA-975957", "R-DME-156827", "R-MMU-5649702", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-HSA-9636003", "R-DME-72649", "R-HSA-156827", "R-RNO-72689", "R-HSA-5649702", "R-MMU-72649", "R-HSA-192823", "R-SSC-72695", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-MMU-110329", "R-DDI-9954716", "R-HSA-110329", "R-HSA-110330", "R-SSC-72702", "R-CFA-72689", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-72695", "R-DME-975956", "R-MMU-72702", "R-DME-975957", "R-BTA-9954716", "R-CFA-9954716", "R-SPO-72649", "R-DRE-975956", "R-SPO-72695", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-110328", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-HSA-9754678", "R-HSA-72649", "R-MMU-156827", "R-SSC-72649", "R-BTA-1799339", "R-BTA-9954714", "R-BTA-110329", "R-DRE-72649", "R-SCE-72649", "R-HSA-975957", "R-HSA-9629232", "R-DME-9954714", "R-DRE-72702", "R-CFA-975956", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-SSC-9954716", "R-CFA-72649", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CFA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", 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Repair Associated with NEIL1", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-72649:r:Translation initiation complex formation", 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GG-NER", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2132295:r:MHC class II antigen presentation", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-983189:r:Kinesins", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-983189:r:Kinesins", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-983189:r:Kinesins", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6782135:r:Dual incision in TC-NER", "R-BTA-9833482:r:PKR-mediated signaling", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Homologous_superfamily"}, "IPR010995": {"description": "DNA repair Rad51/transcription factor NusA, alpha-helical", "go_ids": ["GO:0000166"], "go_terms": ["GO:0000166:nucleotide binding:F"], "name": "DNA_repair_Rad51/TF_NusA_a-hlx", "pathway_ids": ["R-GGA-912446", "R-GGA-5685938", "R-HSA-5685942", "R-GGA-5685942", "R-HSA-5693616", "R-BTA-5685938", "R-HSA-9704646", "R-GGA-351433", "R-GGA-5693616", "R-GGA-265976", "R-MMU-5693616", "R-HSA-8953750", "R-DME-5693616", "R-MMU-5685938", "R-BTA-912446", "R-CFA-5693568", "R-HSA-9709570", "R-HSA-912446", "R-BTA-5693616", "R-SCE-5693616", "R-SPO-5693616", "R-BTA-5693579", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-HSA-9701192", "R-BTA-5693568", "R-GGA-5693568", "R-HSA-9709603", "R-MMU-5685942", "R-MMU-912446", "R-CFA-912446", "R-CFA-5685942", "R-CFA-5685938", "R-CFA-5693579", "R-HSA-9704331", "R-CFA-5693616", "R-BTA-5685942", "R-HSA-5693554", "R-HSA-5693579", "R-GGA-5693579"], "pathways": ["R-GGA-912446:r:Meiotic recombination", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-GGA-265976:r:Homologous DNA pairing and strand exchange", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DME-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-912446:r:Meiotic recombination", "R-CFA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-912446:r:Meiotic recombination", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SCE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-GGA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-912446:r:Meiotic recombination", "R-CFA-912446:r:Meiotic recombination", "R-CFA-5685942:r:HDR through Homologous Recombination (HRR)", "R-CFA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CFA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-CFA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-GGA-5693579:r:Homologous DNA Pairing and Strand Exchange"], "type": "Homologous_superfamily"}, "IPR010996": {"description": "Crossover junction endonuclease MUS81-like, HHH domain", "go_ids": [], "go_terms": [], "name": "HHH_MUS81", "pathway_ids": ["R-BTA-5649702", "R-BTA-110373", "R-MMU-5649702", "R-MMU-5693571", "R-SPO-5693568", "R-BTA-5689880", "R-HSA-5689880", "R-DRE-110381", "R-DRE-5649702", "R-SCE-110362", "R-RNO-110362", "R-DRE-110373", "R-MMU-110381", "R-HSA-5649702", "R-DRE-110362", "R-RNO-110381", "R-DRE-6783310", "R-DRE-5693568", "R-MMU-5689880", "R-MMU-110362", "R-XTR-5693568", "R-BTA-5651801", "R-MMU-5693568", "R-HSA-5693568", "R-BTA-73930", "R-HSA-110373", "R-DRE-5689880", "R-SCE-5693568", "R-MMU-5651801", "R-HSA-110362", "R-BTA-110381", "R-HSA-5651801", "R-BTA-110362", "R-RNO-5693571", "R-HSA-6783310", "R-RNO-5689880", "R-MMU-6783310", "R-RNO-5649702", "R-MMU-110373", "R-HSA-5693571", "R-RNO-73930", "R-HSA-110381", "R-RNO-5693568", "R-RNO-5651801", "R-MMU-73930", "R-DRE-5651801", "R-DRE-73930", "R-HSA-73930", "R-RNO-110373", "R-RNO-6783310"], "pathways": ["R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-BTA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SPO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-SCE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-XTR-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-5689880:r:Ub-specific processing proteases", "R-SCE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-RNO-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR010997": {"description": "HRDC-like superfamily", "go_ids": ["GO:0000166"], "go_terms": ["GO:0000166:nucleotide binding:F"], "name": "HRDC-like_sf", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-HSA-174414", "R-MMU-9770562", "R-HSA-73980", "R-DDI-73776", "R-MMU-6804756", "R-DME-72163", "R-BTA-76071", "R-SPO-6781823", "R-DDI-6782210", "R-SPO-9930044", "R-DDI-72163", "R-HSA-167158", "R-MMU-5685938", "R-MMU-75955", "R-MMU-112382", "R-BTA-76066", "R-DME-75955", "R-BTA-9018519", "R-MMU-69473", "R-SCE-6807505", "R-SPO-76042", "R-MMU-174414", "R-HSA-73776", "R-BTA-77075", "R-SCE-6791226", "R-DDI-674695", "R-DME-72203", "R-DME-72086", "R-MMU-76061", "R-HSA-76061", "R-SPO-6796648", "R-DME-75953", "R-HSA-749476", "R-DME-6782135", "R-SCE-76061", "R-MMU-9930044", "R-BTA-72163", "R-MMU-6791226", "R-BTA-75955", "R-BTA-75953", "R-SPO-9018519", "R-HSA-69473", "R-BTA-6782135", "R-MMU-72163", "R-SPO-76066", "R-HSA-6803529", "R-HSA-167242", "R-HSA-8851708", "R-HSA-167161", "R-HSA-72163", "R-DME-112382", "R-HSA-6804756", "R-RNO-76061", "R-HSA-9670095", "R-HSA-167160", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-DDI-113418", "R-MMU-3108214", "R-MMU-72086", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5685942", "R-HSA-5578749", "R-SPO-76061", "R-DME-5578749", "R-DME-77075", "R-DME-73779", "R-BTA-5578749", "R-RNO-9930044", "R-DME-9770562", "R-DME-73776", "R-BTA-6781823", "R-MMU-6781823", "R-HSA-203927", "R-DDI-6796648", "R-HSA-912446", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-HSA-73780", "R-DDI-76042", "R-MMU-5693579", "R-MMU-73776", "R-HSA-167172", "R-HSA-5693568", "R-DME-3108214", "R-MMU-5693607", "R-HSA-9701192", "R-BTA-73779", "R-SCE-73779", "R-HSA-76071", "R-DME-113418", "R-HSA-72203", "R-MMU-6796648", "R-RNO-76071", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-SCE-6781823", "R-MMU-76071", "R-HSA-9709603", "R-BTA-674695", "R-RNO-76066", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-167290", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-HSA-5693579", "R-SPO-72163", "R-BTA-6807505", "R-BTA-72203", "R-HSA-112382", "R-HSA-73779", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-HSA-5693616", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-BTA-76042", "R-SPO-6807505", "R-DME-6791226", 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RNA decay", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Homologous_superfamily"}, "IPR010998": {"description": "Integrase/recombinase, N-terminal", "go_ids": [], "go_terms": [], "name": "Integrase_recombinase_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR010999": {"description": "Retroviral matrix protein", "go_ids": [], "go_terms": [], "name": "Retrovr_matrix", "pathway_ids": ["R-HSA-180910", "R-HSA-164516", "R-HSA-162585", "R-HSA-1169408", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-164525", "R-HSA-162594", "R-HSA-162592", "R-HSA-177539", "R-HSA-174490", "R-HSA-175567", "R-HSA-175474", "R-HSA-198933", "R-HSA-174495", "R-HSA-173107"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-174495:r:Synthesis And Processing Of GAG, GAGPOL Polyproteins", "R-HSA-173107:r:Binding and entry of HIV virion"], "type": "Homologous_superfamily"}, "IPR011001": {"description": "Saposin-like", "go_ids": [], "go_terms": [], "name": "Saposin-like", "pathway_ids": ["R-DDI-9840310", "R-HSA-6798695", "R-RNO-9840310", "R-HSA-5688031", "R-MMU-9840310", "R-HSA-375276", "R-HSA-9840310", "R-RNO-5683826", "R-MMU-375276", "R-MMU-5683826", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-BTA-9840310", "R-HSA-418594", "R-HSA-5688890", "R-HSA-5683826", "R-RNO-375276", "R-CEL-9840310", "R-HSA-6803157", "R-MMU-6798695", "R-BTA-5683826", "R-RNO-6798695", "R-HSA-5688849", "R-MMU-114608"], "pathways": ["R-DDI-9840310:r:Glycosphingolipid catabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-5688031:r:Defective pro-SFTPB causes SMDP1 and RDS", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-5683826:r:Surfactant metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR011002": {"description": 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"R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine", "R-HSA-6787639:r:GDP-fucose biosynthesis", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-2132295:r:MHC class II antigen presentation", "R-CEL-72731:r:Recycling of eIF2:GDP", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6787639:r:GDP-fucose biosynthesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "type": "Homologous_superfamily"}, "IPR011005": {"description": "Dihydropteroate synthase-like superfamily", "go_ids": [], "go_terms": [], "name": "Dihydropteroate_synth-like_sf", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-MMU-9013407", "R-CEL-9759218", "R-RNO-9759218", "R-RNO-9013407", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-DDI-1614635", "R-MMU-9759218", "R-MMU-1614635", "R-HSA-156581", "R-HSA-9759218", "R-RNO-156581", "R-HSA-3359467", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-156581:r:Methylation", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Homologous_superfamily"}, "IPR011006": {"description": "CheY-like superfamily", "go_ids": [], "go_terms": [], "name": "CheY-like_sf", "pathway_ids": ["R-DDI-418457", "R-SCE-2465910", "R-DDI-418555", "R-SPO-2465910", "R-DDI-111957"], "pathways": ["R-DDI-418457:r:cGMP effects", "R-SCE-2465910:r:MASTL Facilitates Mitotic Progression", "R-DDI-418555:r:G alpha (s) signalling events", "R-SPO-2465910:r:MASTL Facilitates Mitotic Progression", "R-DDI-111957:r:Cam-PDE 1 activation"], "type": "Homologous_superfamily"}, "IPR011008": {"description": "Dimeric alpha-beta barrel", "go_ids": [], "go_terms": [], "name": "Dimeric_a/b-barrel", "pathway_ids": ["R-CEL-9013407", "R-HSA-9013409", "R-MMU-9013407", "R-HSA-9638482", "R-DRE-9013407", "R-HSA-9637628", "R-HSA-9013407", "R-DME-9013407"], "pathways": ["R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-9638482:r:Metal ion assimilation from the host", "R-DRE-9013407:r:RHOH GTPase cycle", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DME-9013407:r:RHOH GTPase cycle"], "type": "Homologous_superfamily"}, "IPR011009": {"description": "Protein kinase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Kinase-like_dom_sf", "pathway_ids": ["R-HSA-1266695", "R-MMU-2428933", "R-SSC-3214858", "R-HSA-9706374", "R-DRE-1253288", "R-DME-9018519", "R-CEL-389513", "R-RNO-8984722", "R-CFA-5673000", "R-CEL-5627117", "R-HSA-5357786", "R-HSA-5602636", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-2173791", "R-RNO-8963896", "R-HSA-204005", "R-CEL-212718", "R-SSC-438066", "R-DRE-399956", "R-DME-1250196", "R-MMU-450604", "R-SSC-9754119", "R-CEL-9754119", "R-SSC-389359", "R-RNO-168638", "R-DDI-5627123", "R-DRE-5693565", "R-DME-5607764", "R-HSA-1257604", "R-SCE-5687128", "R-PFA-381042", "R-RNO-2559585", "R-HSA-9702605", "R-MMU-9648002", "R-RNO-2500257", "R-HSA-74751", "R-BTA-416993", "R-DME-5654693", "R-BTA-5663220", "R-HSA-1251932", "R-HSA-1250347", "R-CEL-416476", "R-DRE-9833482", "R-BTA-5627123", "R-RNO-5663213", "R-DME-5635838", "R-BTA-9839389", "R-HSA-9673770", "R-CEL-5140745", "R-MMU-190373", "R-MMU-9022692", "R-RNO-200425", "R-RNO-9619229", "R-HSA-113418", "R-DDI-418592", "R-SSC-9931269", "R-XTR-2173796", "R-BTA-71064", "R-HSA-8851805", "R-DME-975144", "R-BTA-9013420", "R-MMU-2500257", "R-RNO-69202", "R-HSA-9020591", "R-CEL-1483213", "R-MMU-5693548", "R-MMU-2028269", "R-CEL-9614399", "R-MMU-428890", "R-SPO-4419969", "R-GGA-6804757", "R-SSC-2424491", "R-DDI-3371571", "R-BTA-74749", "R-RNO-2428928", "R-DME-3000170", "R-SPO-9837999", "R-BTA-4419969", "R-HSA-165159", "R-CFA-6804756", "R-MMU-399719", "R-DME-975163", "R-SSC-5673000", "R-GGA-8939243", "R-MMU-9909505", "R-CEL-8849470", "R-SCE-399997", "R-RNO-8948751", "R-RNO-6785807", "R-MMU-1266695", "R-MMU-114604", "R-HSA-9665251", "R-RNO-111995", "R-RNO-3301854", "R-DDI-6804760", "R-RNO-9607240", "R-CEL-195253", "R-DDI-2559586", "R-CEL-5673000", "R-CEL-5621575", "R-RNO-9634597", "R-HSA-8939245", "R-MMU-8851805", "R-MMU-211163", "R-HSA-9603381", 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"R-BTA-4641262", "R-DRE-3371571", "R-GGA-5693607", "R-HSA-8935690", "R-DRE-201556", "R-BTA-5654689", "R-SSC-375165", "R-RNO-5654712", "R-RNO-9634638", "R-MMU-9614399", "R-DME-180336", "R-DDI-9009391", "R-HSA-1251985", "R-RNO-1257604", "R-RNO-8980692", "R-DME-110056", "R-RNO-174178", "R-HSA-8862803", "R-GGA-1502540", "R-BTA-163615", "R-GGA-265976", "R-DDI-200425", "R-MMU-174178", "R-RNO-1489509", "R-MMU-418594", "R-DDI-9013422", "R-BTA-69563", "R-RNO-5654719", "R-MMU-69202", "R-CEL-877300", "R-CEL-5654712", "R-BTA-445989", "R-BTA-76005", "R-CEL-9013406", "R-HSA-6782210", "R-CEL-399956", "R-MMU-5218900", "R-HSA-9627069", "R-RNO-177929", "R-RNO-6788467", "R-CFA-1433557", "R-HSA-112399", "R-SCE-9031628", "R-MMU-936964", "R-CEL-69273", "R-GGA-69601", "R-PFA-430116", "R-HSA-3000170", "R-DME-5578775", "R-MMU-1227986", "R-HSA-109704", "R-MMU-190371", "R-DDI-9648002", "R-SCE-6811555", "R-DME-3301854", "R-CFA-8854521", "R-RNO-187577", "R-HSA-933541", "R-SCE-1483213", "R-HSA-170968", 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"R-HSA-9630791", "R-HSA-6804757", "R-CEL-5654732", "R-DRE-6798695", "R-BTA-156711", "R-CEL-6804756", "R-BTA-9634638", "R-DRE-9020702", "R-DRE-76005", "R-RNO-8865999", "R-GGA-3928662", "R-CEL-525793", "R-HSA-9927354", "R-CEL-69200", "R-SCE-432142", "R-HSA-5603029", "R-HSA-2404192", "R-HSA-166058", "R-SPO-2559582", "R-RNO-5205685", "R-HSA-209560", "R-CEL-9860927", "R-BTA-3301854", "R-MMU-442742", "R-HSA-9683610", "R-MMU-2559586", "R-CEL-5628897", "R-RNO-5578768", "R-CEL-180292", "R-BTA-3371571", "R-SPO-5218920", "R-SSC-6804114", "R-SPO-179409", "R-HSA-9673768", "R-MMU-442729", "R-CEL-1250196", "R-DME-881907", "R-DDI-203615", "R-MMU-8876198", "R-CEL-5674499", "R-SCE-2029482", "R-MMU-6798695", "R-DDI-381042", "R-RNO-6794361", "R-MMU-9034013", "R-XTR-2980767", "R-HSA-8940973", "R-DRE-6788467", "R-MMU-450385", "R-HSA-416550", "R-RNO-444257", "R-CEL-8863795", "R-DRE-9842663", "R-SPO-1474151", "R-DDI-1660499", "R-XTR-2467813", "R-BTA-5654720", "R-DDI-69473", "R-CEL-1502540", "R-RNO-450520", "R-DDI-75815", "R-RNO-2029482", "R-RNO-5668599", "R-HSA-5578768", "R-BTA-186763", "R-BTA-9754119", "R-CEL-8847993", "R-DRE-5676590", "R-RNO-69656", "R-DRE-449836", "R-RNO-114508", "R-RNO-9839389", "R-HSA-432722", "R-RNO-1307965", "R-BTA-174178", "R-DRE-2465910", "R-HSA-380972", "R-BTA-171007", "R-DME-170968", "R-HSA-1839122", "R-MMU-168928", "R-HSA-2500257", "R-HSA-445355", "R-RNO-8854518", "R-HSA-9665246", "R-HSA-2173791", "R-DME-9627069", "R-HSA-5654706", "R-DRE-2500257", "R-BTA-399955", "R-RNO-186797", "R-GGA-434001", "R-HSA-9824585", "R-BTA-8854050", "R-RNO-8985947", "R-HSA-5654227", "R-DRE-9013148", "R-RNO-9007892", "R-HSA-3928663", "R-MMU-1059683", "R-HSA-5627123", "R-CEL-4420097", "R-MMU-9927354", "R-MMU-416482", "R-CEL-8849471", "R-BTA-5607764", "R-HSA-444257", "R-DRE-5654695", "R-CEL-8874081", "R-DRE-1251985", "R-HSA-9664422", "R-RNO-2514853", "R-SCE-444257", "R-SSC-8875656", "R-SPO-141430", "R-DME-69273", "R-CEL-9634638", "R-HSA-5689880", "R-HSA-427413", "R-DME-9652282", "R-MMU-9013408", "R-MMU-210990", "R-SPO-389357", "R-HSA-1489509", "R-MMU-210993", "R-DME-5654732", "R-BTA-2299718", "R-DDI-6804115", "R-BTA-1963642", "R-HSA-9639288", "R-MMU-8854214", "R-SCE-6807505", "R-SPO-76042", "R-MMU-5663213", "R-SCE-6804757", "R-SPO-5668599", "R-HSA-9702632", "R-DDI-6804756", "R-MMU-3371378", "R-DME-1295596", "R-CEL-3000170", "R-SPO-2565942", "R-DME-209209", "R-MMU-5673001", "R-DME-2559582", "R-BTA-881907", "R-RNO-2562578", "R-SCE-6804115", "R-PFA-5689896", "R-MMU-72163", "R-PFA-442720", "R-DME-209461", "R-DRE-69601", "R-RNO-5628897", "R-SCE-202670", "R-HSA-9764725", "R-DRE-912694", "R-BTA-2173788", "R-HSA-6804760", "R-CEL-442729", "R-MMU-190372", "R-HSA-5637810", "R-MMU-165181", "R-CFA-198753", "R-CEL-180024", "R-SPO-5627123", "R-CEL-5696395", "R-HSA-164378", "R-DME-162658", "R-CEL-1660517", "R-HSA-445144", "R-MMU-73772", "R-DME-112411", "R-DME-1632852", "R-MMU-69273", "R-DME-201451", "R-DDI-3899300", "R-BTA-202433", "R-RNO-8851907", "R-MMU-416550", "R-DME-69017", "R-HSA-5625900", "R-MMU-430116", "R-MMU-2980767", "R-MMU-8980692", "R-HSA-9662834", "R-HSA-2029485", "R-RNO-69601", "R-SCE-162658", "R-SCE-6804758", "R-DRE-1912408", "R-HSA-9013423", "R-CEL-69656", "R-DME-392517", "R-HSA-190374", "R-HSA-8851907", "R-CEL-190377", "R-CFA-6811558", "R-CEL-354192", "R-CEL-75815", "R-CEL-373752", "R-HSA-68962", "R-MMU-512988", "R-HSA-1250196", "R-DME-416476", "R-HSA-1538133", "R-BTA-437239", "R-SPO-9013420", "R-RNO-418457", "R-HSA-9669926", "R-BTA-1538133", "R-DRE-9031628", "R-RNO-113418", "R-DME-209360", "R-MMU-437239", "R-MMU-71064", "R-MMU-212676", "R-RNO-9856649", "R-DME-936837", "R-RNO-139910", "R-MMU-9028731", "R-HSA-156711", "R-SPO-1660514", "R-DME-176412", "R-DDI-166208", "R-MMU-391160", "R-BTA-111933", "R-RNO-936837", "R-MMU-1660499", "R-MMU-75153", "R-HSA-9755779", "R-SPO-75815", "R-MMU-8943724", "R-HSA-5603037", "R-DRE-8874081", "R-SCE-392451", "R-MMU-444257", "R-HSA-187024", "R-SPO-199418", "R-HSA-111465", "R-MMU-2562578", "R-SPO-75153", "R-BTA-6807505", "R-CEL-186797", "R-DME-5654706", "R-CEL-9020702", "R-BTA-442720", "R-DDI-8854050", "R-MMU-8953750", "R-DME-209155", "R-RNO-5627123", "R-MMU-6785631", "R-HSA-1606341", "R-DRE-399954", "R-DME-199920", "R-HSA-187042", "R-BTA-9013424", "R-CEL-9652282", "R-RNO-8866376", "R-MMU-9020933", "R-HSA-5676590", "R-SSC-9732724", "R-DME-8964616", "R-DRE-198323", "R-DME-933542", "R-SPO-9013106", "R-HSA-380320", "R-DDI-9020702", "R-SPO-8934903", "R-SCE-5607764", "R-HSA-9649948", "R-BTA-9837999", "R-MMU-1660514", "R-SCE-9664873", "R-SCE-9013420", "R-MMU-975163", "R-HSA-8878166", "R-RNO-9034013", "R-MMU-5693568", "R-CEL-6785631", "R-MMU-76042", "R-SCE-9856530", "R-SSC-163680", "R-RNO-1538133", "R-RNO-389357", "R-DRE-5654720", "R-CEL-6807505", "R-DME-1227986", "R-RNO-5654693", "R-DRE-9007892", "R-RNO-8853659", "R-CEL-177929", "R-CEL-9833482", "R-MMU-5654700", "R-HSA-2033515", "R-DME-2173791", "R-PFA-381676", "R-HSA-5467340", "R-BTA-416476", "R-MMU-195399", "R-DME-399997", "R-SCE-674695", "R-BTA-1483191", "R-RNO-9028731", "R-SPO-429947", "R-CEL-442720", "R-HSA-187577", "R-SPO-176408", "R-RNO-8943724", "R-GGA-2173789", "R-SPO-5687128", "R-HSA-209543", "R-CEL-432040", "R-RNO-9841251", "R-DME-195253", "R-HSA-9665245", "R-SCE-1169091", "R-SCE-5693565", "R-HSA-1236382", "R-DDI-5693607", "R-RNO-5654687", "R-MMU-446343", "R-HSA-937072", "R-HSA-5607764", "R-BTA-68881", "R-MMU-1358803", "R-DME-4419969", "R-HSA-9028731", "R-DDI-381070", "R-MMU-8854691", "R-MMU-3769402", "R-RNO-2299718", "R-MMU-8932505", "R-BTA-69273", "R-MMU-8984722", "R-BTA-2173791", "R-SCE-113418", "R-DME-77387", "R-HSA-8964616", "R-HSA-354194", "R-GGA-432142", "R-DME-212676", "R-MMU-2404192", "R-CEL-2029482", "R-GGA-2173791", "R-HSA-9851151", "R-HSA-9830674", "R-BTA-2730905", "R-DME-190322", "R-CEL-68949", "R-SCE-525793", "R-HSA-5687128", "R-XTR-176412", "R-BTA-450302", "R-RNO-1483248", "R-RNO-5654720", "R-MMU-166208", "R-DDI-5607764", "R-MMU-6811555", "R-DRE-5654688", "R-SCE-2871837", "R-DME-2173789", "R-SCE-164378", "R-HSA-9013405", "R-SSC-9766229", "R-HSA-6807505", "R-HSA-9604323", "R-CFA-450341", "R-CEL-442742", "R-RNO-2028269", "R-BTA-1227986", "R-MMU-1632852", "R-DDI-73776", "R-BTA-8963896", "R-RNO-8953750", "R-HSA-9027284", "R-CEL-5654219", "R-MMU-5654221", "R-PFA-432040", "R-MMU-5689880", "R-DDI-68962", "R-PFA-180024", "R-RNO-8854050", "R-BTA-438066", "R-HSA-512988", "R-SSC-1170546", "R-DDI-198753", "R-DME-211163", "R-CEL-182971", "R-SCE-200425", "R-DME-5663213", "R-RNO-165159", "R-GGA-5673001", "R-DME-9607240", "R-SPO-6811558", "R-MMU-9013407", "R-MMU-380259", "R-MMU-170968", "R-BTA-381676", "R-MMU-9634597", "R-HSA-3000171", "R-MMU-3134975", "R-DRE-186763", "R-HSA-373752", "R-RNO-2980767", "R-RNO-202670", "R-DDI-111995", "R-HSA-190377", "R-HSA-389356", "R-DRE-6785807", "R-MMU-171007", "R-DME-442720", "R-HSA-399954", "R-BTA-9768727", "R-BTA-69017", "R-DME-390089", "R-DRE-8980692", "R-DME-2559586", "R-DDI-113418", "R-MMU-72086", "R-SPO-73779", "R-DME-1963642", "R-CEL-2173789", "R-RNO-9013420", "R-CEL-9031628", "R-DME-9909505", "R-MMU-187577", "R-RNO-198693", "R-RNO-9860276", "R-CEL-5687128", "R-SCE-69601", "R-DRE-2559580", "R-HSA-9735871", "R-DME-111932", "R-DRE-109704", "R-CEL-5654227", "R-HSA-9824272", "R-RNO-199920", "R-SCE-76005", "R-HSA-8849468", "R-RNO-166208", "R-DRE-2142789", "R-RNO-2565942", "R-MMU-429947", "R-DDI-8876198", "R-HSA-111446", "R-DDI-112409", "R-BTA-209560", "R-RNO-2173789", "R-DRE-174178", "R-RNO-937041", "R-SCE-75153", "R-HSA-8852405", "R-DRE-2028269", "R-RNO-437239", "R-HSA-5654726", "R-DME-2179392", "R-RNO-9755511", "R-MMU-9013424", "R-MMU-3371571", "R-DME-174184", "R-MMU-176412", "R-BTA-6811555", "R-MMU-1474151", "R-DME-74749", "R-HSA-983170", "R-DDI-4419969", "R-GGA-3928665", "R-DME-1181150", "R-DDI-162658", "R-BTA-210993", "R-DME-9007892", "R-HSA-674695", "R-DRE-193648", "R-HSA-169131", "R-DRE-418592", "R-MMU-418555", "R-HSA-937039", "R-MMU-1660516", "R-CEL-6798695", "R-SCE-1660514", "R-HSA-9670439", "R-HSA-190375", "R-MMU-8865999", "R-MMU-432142", "R-HSA-68881", "R-DDI-5675482", "R-DME-2029482", "R-MMU-445989", "R-CEL-2559582", "R-RNO-202427", "R-BTA-8866376", "R-MMU-392451", "R-HSA-8939211", "R-BTA-162658", "R-DDI-9841251", "R-CEL-5654700", "R-MMU-187042", "R-RNO-73728", "R-MMU-2029485", "R-DME-190372", "R-DME-214844", "R-SPO-72086", "R-CEL-8854214", "R-SSC-3371571"], "pathways": ["R-HSA-1266695:r:Interleukin-7 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-SSC-3214858:r:RMTs methylate histone arginines", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-DRE-1253288:r:Downregulation of ERBB4 signaling", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-CFA-5673000:r:RAF activation", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5602636:r:IKBKB deficiency causes SCID", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-8963896:r:HDL assembly", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-SSC-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-SSC-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-CEL-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-PFA-381042:r:PERK regulates gene expression", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-HSA-9702605:r:pexidartinib-resistant FLT3 mutants", "R-MMU-9648002:r:RAS processing", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-416476:r:G alpha (q) signalling events", "R-DRE-9833482:r:PKR-mediated signaling", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-5635838:r:Activation of SMO", "R-BTA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-RNO-200425:r:Carnitine shuttle", "R-RNO-9619229:r:Activation of RAC1 downstream of NMDARs", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-DDI-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-XTR-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-71064:r:Lysine catabolism", "R-HSA-8851805:r:MET activates RAS signaling", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-BTA-9013420:r:RHOU GTPase cycle", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-9020591:r:Interleukin-12 signaling", "R-CEL-1483213:r:Synthesis of PE", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-2028269:r:Signaling by Hippo", "R-CEL-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-SSC-2424491:r:DAP12 signaling", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-BTA-74749:r:Signal attenuation", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-DME-3000170:r:Syndecan interactions", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-165159:r:MTOR signalling", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-SSC-5673000:r:RAF activation", "R-GGA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-8849470:r:PTK6 Regulates Cell Cycle", "R-SCE-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-RNO-111995:r:phospho-PLA2 pathway", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DDI-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9607240:r:FLT3 Signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-5673000:r:RAF activation", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-9634597:r:GPER1 signaling", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-MMU-211163:r:AKT-mediated inactivation of FOXO1A", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-2465910:r:MASTL Facilitates Mitotic Progression", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-8942233:r:Intestinal infectious diseases", "R-SSC-982772:r:Growth hormone receptor signaling", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-DME-164378:r:PKA activation in glucagon signalling", "R-BTA-70221:r:Glycogen breakdown (glycogenolysis)", "R-DME-198753:r:ERK/MAPK targets", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-MMU-9007892:r:Interleukin-38 signaling", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-CFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-156711:r:Polo-like kinase mediated events", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-GGA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-8851805:r:MET activates RAS signaling", "R-MMU-1912408:r:Pre-NOTCH Transcription and Translation", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9648002:r:RAS processing", "R-CEL-165158:r:Activation of AKT2", "R-BTA-9833482:r:PKR-mediated signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-2871796:r:FCERI mediated MAPK activation", "R-SCE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SCE-2179392:r:EGFR Transactivation by Gastrin", "R-DME-429947:r:Deadenylation of mRNA", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-BTA-1181150:r:Signaling by NODAL", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-8874081:r:MET activates PTK2 signaling", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-111933:r:Calmodulin induced events", "R-MMU-198765:r:Signalling to ERK5", "R-MMU-165158:r:Activation of AKT2", "R-SPO-164378:r:PKA activation in glucagon signalling", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-DRE-114516:r:Disinhibition of SNARE formation", "R-DME-389513:r:Co-inhibition by CTLA4", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9706369:r:Negative regulation of FLT3", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-69231:r:Cyclin D associated events in G1", "R-CEL-77387:r:Insulin receptor recycling", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-HSA-200425:r:Carnitine shuttle", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-CFA-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-182971:r:EGFR downregulation", "R-DDI-1538133:r:G0 and Early G1", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-SSC-8854521:r:Interaction between PHLDA1 and AURKA", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-373753:r:Nephrin family interactions", "R-HSA-432142:r:Platelet sensitization by LDL", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-5635838:r:Activation of SMO", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-75893:r:TNF signaling", "R-DRE-191650:r:Regulation of gap junction activity", "R-DME-9749641:r:Aspirin ADME", "R-HSA-1483213:r:Synthesis of PE", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-DME-1266695:r:Interleukin-7 signaling", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-392517:r:Rap1 signalling", "R-HSA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-SSC-877300:r:Interferon gamma signaling", "R-HSA-9613354:r:Lipophagy", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DRE-5654727:r:Negative regulation of FGFR2 signaling", "R-PFA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-GGA-201451:r:Signaling by BMP", "R-HSA-8854521:r:Interaction between PHLDA1 and AURKA", "R-DME-202670:r:ERKs are inactivated", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-CEL-202424:r:Downstream TCR signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-165158:r:Activation of AKT2", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-SPO-8948751:r:Regulation of PTEN stability and activity", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9669933:r:Signaling by kinase domain mutants of KIT", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-RNO-9696270:r:RND2 GTPase cycle", "R-DME-209425:r:Transcriptional activtion by AP-1 transcription factor", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-199920:r:CREB phosphorylation", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-68875:r:Mitotic Prophase", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-SSC-3928664:r:Ephrin signaling", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-BTA-165158:r:Activation of AKT2", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9630794:r:Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-383280:r:Nuclear Receptor transcription pathway", "R-MMU-877300:r:Interferon gamma signaling", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-112409:r:RAF-independent MAPK1/3 activation", "R-GGA-1433559:r:Regulation of KIT signaling", "R-DDI-165158:r:Activation of AKT2", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-CFA-8854518:r:AURKA Activation by TPX2", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-198753:r:ERK/MAPK targets", "R-SCE-198753:r:ERK/MAPK targets", "R-DRE-525793:r:Myogenesis", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-9031628:r:NGF-stimulated transcription", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9702624:r:sorafenib-resistant FLT3 mutants", "R-RNO-156711:r:Polo-like kinase mediated events", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DME-390178:r:DS ligand not bound to FT receptor", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DME-209409:r:Formation of the nuclear AP-1 transcription factor 'scaffolding complex'", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-RNO-193648:r:NRAGE signals death through JNK", "R-CFA-4086398:r:Ca2+ pathway", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DME-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-DRE-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-RNO-1483213:r:Synthesis of PE", "R-MMU-200425:r:Carnitine shuttle", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-5673000:r:RAF activation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DRE-5673000:r:RAF activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-BTA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-3371571:r:HSF1-dependent transactivation", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-8935690:r:Digestion", "R-DRE-201556:r:Signaling by ALK", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-DME-110056:r:MAPK3 (ERK1) activation", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-GGA-1502540:r:Signaling by Activin", "R-BTA-163615:r:PKA activation", "R-GGA-265976:r:Homologous DNA pairing and strand exchange", "R-DDI-200425:r:Carnitine shuttle", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-1489509:r:DAG and IP3 signaling", "R-MMU-418594:r:G alpha (i) signalling events", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-69563:r:p53-Dependent G1 DNA Damage Response", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-877300:r:Interferon gamma signaling", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-RNO-177929:r:Signaling by EGFR", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-HSA-112399:r:IRS-mediated signalling", "R-SCE-9031628:r:NGF-stimulated transcription", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-PFA-430116:r:GP1b-IX-V activation signalling", "R-HSA-3000170:r:Syndecan interactions", "R-DME-5578775:r:Ion homeostasis", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-109704:r:PI3K Cascade", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-DDI-9648002:r:RAS processing", "R-SCE-6811555:r:PI5P Regulates TP53 Acetylation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-CFA-8854521:r:Interaction between PHLDA1 and AURKA", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-SCE-1483213:r:Synthesis of PE", "R-HSA-170968:r:Frs2-mediated activation", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-428540:r:Activation of RAC1", "R-DME-68881:r:Mitotic Metaphase/Anaphase Transition", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SCE-389359:r:CD28 dependent Vav1 pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-DME-8939211:r:ESR-mediated signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5621480:r:Dectin-2 family", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-74752:r:Signaling by Insulin receptor", "R-SCE-180024:r:DARPP-32 events", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-BTA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SPO-4086398:r:Ca2+ pathway", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-9706369:r:Negative regulation of FLT3", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DRE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-139910:r:Activation of BMF and translocation to mitochondria", "R-DME-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-CEL-163615:r:PKA activation", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1502540:r:Signaling by Activin", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-3371378:r:Regulation by c-FLIP", "R-DME-171007:r:p38MAPK events", "R-SSC-9759194:r:Nuclear events mediated by NFE2L2", "R-GGA-430116:r:GP1b-IX-V activation signalling", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-GGA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-165158:r:Activation of AKT2", "R-CEL-8849472:r:PTK6 Down-Regulation", "R-HSA-167044:r:Signalling to RAS", "R-DRE-171007:r:p38MAPK events", "R-CEL-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-9018519:r:Estrogen-dependent gene expression", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-DME-430116:r:GP1b-IX-V activation signalling", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-9842663:r:Signaling by LTK", "R-CEL-1483191:r:Synthesis of PC", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-GGA-5635838:r:Activation of SMO", "R-BTA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-209190:r:Phosphorylation of CI", "R-DME-180292:r:GAB1 signalosome", "R-CEL-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-1266695:r:Interleukin-7 signaling", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-6794361:r:Neurexins and neuroligins", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-1227986:r:Signaling by ERBB2", "R-RNO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-GGA-69473:r:G2/M DNA damage checkpoint", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-4086398:r:Ca2+ pathway", "R-CEL-2028269:r:Signaling by Hippo", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-GGA-2672351:r:Stimuli-sensing channels", "R-DME-114516:r:Disinhibition of SNARE formation", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-8866376:r:Reelin signalling pathway", "R-SSC-399719:r:Trafficking of AMPA receptors", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-449836:r:Other interleukin signaling", "R-SCE-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-3295583:r:TRP channels", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-CEL-1181150:r:Signaling by NODAL", "R-BTA-446353:r:Cell-extracellular matrix interactions", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-4086398:r:Ca2+ pathway", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9702596:r:lestaurtinib-resistant FLT3 mutants", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-373753:r:Nephrin family interactions", "R-HSA-381042:r:PERK regulates gene expression", "R-RNO-877312:r:Regulation of IFNG signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DME-5610787:r:Hedgehog 'off' state", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-SPO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-6806942:r:MET Receptor Activation", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-DME-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-176412:r:Phosphorylation of the APC/C", "R-RNO-445144:r:Signal transduction by L1", "R-SSC-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-429947:r:Deadenylation of mRNA", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-DME-8985947:r:Interleukin-9 signaling", "R-DME-68884:r:Mitotic Telophase/Cytokinesis", "R-CFA-445144:r:Signal transduction by L1", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-XTR-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9696264:r:RND3 GTPase cycle", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-HSA-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-111933:r:Calmodulin induced events", "R-DRE-8983432:r:Interleukin-15 signaling", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-182971:r:EGFR downregulation", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-170968:r:Frs2-mediated activation", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-8985947:r:Interleukin-9 signaling", "R-DME-373752:r:Netrin-1 signaling", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-HSA-8854214:r:TBC/RABGAPs", "R-DDI-165159:r:MTOR signalling", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-PFA-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-111446:r:Activation of BIM and translocation to mitochondria", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-RNO-445355:r:Smooth Muscle Contraction", "R-CEL-5610787:r:Hedgehog 'off' state", "R-DME-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-9674404:r:Sorafenib-resistant PDGFR mutants", "R-CEL-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-9717323:r:ceritinib-resistant ALK mutants", "R-BTA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-XTR-1538133:r:G0 and Early G1", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-DRE-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-SPO-69231:r:Cyclin D associated events in G1", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-BTA-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-8878166:r:Transcriptional regulation by RUNX2", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-BTA-109704:r:PI3K Cascade", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-RNO-1181150:r:Signaling by NODAL", "R-CEL-69478:r:G2/M DNA replication checkpoint", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DME-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-MMU-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-373753:r:Nephrin family interactions", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-SPO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SCE-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SSC-399954:r:Sema3A PAK dependent Axon repulsion", "R-SSC-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-9020956:r:Interleukin-27 signaling", "R-BTA-68911:r:G2 Phase", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-418457:r:cGMP effects", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-190370:r:FGFR1b ligand binding and activation", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-SCE-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-201556:r:Signaling by ALK", "R-BTA-9013407:r:RHOH GTPase cycle", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SPO-9634597:r:GPER1 signaling", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-DME-1483213:r:Synthesis of PE", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-111933:r:Calmodulin induced events", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DDI-68949:r:Orc1 removal from chromatin", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SPO-202670:r:ERKs are inactivated", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-201688:r:WNT mediated activation of DVL", "R-BTA-9766229:r:Degradation of CDH1", "R-CEL-201681:r:TCF dependent signaling in response to WNT", "R-SPO-444257:r:RSK activation", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-SCE-168638:r:NOD1/2 Signaling Pathway", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-CEL-72086:r:mRNA Capping", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-SCE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DRE-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9833110:r:RSV-host interactions", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-CEL-2142789:r:Ubiquinol biosynthesis", "R-DME-1489509:r:DAG and IP3 signaling", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-XTR-156711:r:Polo-like kinase mediated events", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-DME-9013407:r:RHOH GTPase cycle", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-GGA-351451:r:Homologous recombination repair of replication-dependent double-strand breaks", "R-BTA-5635838:r:Activation of SMO", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-111931:r:PKA-mediated phosphorylation of CREB", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DRE-9020958:r:Interleukin-21 signaling", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-163560:r:Triglyceride catabolism", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-MMU-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-8853659:r:RET signaling", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-432395:r:Degradation of TIM", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-SSC-8851805:r:MET activates RAS signaling", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-163615:r:PKA activation", "R-DME-432501:r:Transcription repression by PER and activation by PDP1", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-9013026:r:RHOB GTPase cycle", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-DME-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-RNO-9020591:r:Interleukin-12 signaling", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SSC-8849470:r:PTK6 Regulates Cell Cycle", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-SSC-8935690:r:Digestion", "R-DDI-202424:r:Downstream TCR signaling", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-CEL-9013407:r:RHOH GTPase cycle", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-8980692:r:RHOA GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5610787:r:Hedgehog 'off' state", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SCE-165158:r:Activation of AKT2", "R-HSA-9702577:r:semaxanib-resistant FLT3 mutants", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-432524:r:Degradation of PER", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-1502540:r:Signaling by Activin", "R-BTA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-1181150:r:Signaling by NODAL", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-GGA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-201451:r:Signaling by BMP", "R-DRE-877312:r:Regulation of IFNG signaling", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-DDI-437239:r:Recycling pathway of L1", "R-DME-111933:r:Calmodulin induced events", "R-RNO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-75153:r:Apoptotic execution phase", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-GGA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DME-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-354192:r:Integrin signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-68881:r:Mitotic Metaphase/Anaphase Transition", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-MMU-5621480:r:Dectin-2 family", "R-SSC-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-GGA-912631:r:Regulation of signaling by CBL", "R-BTA-110056:r:MAPK3 (ERK1) activation", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-8983711:r:OAS antiviral response", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SCE-2465910:r:MASTL Facilitates Mitotic Progression", "R-BTA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-74749:r:Signal attenuation", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-418885:r:DCC mediated attractive signaling", "R-SPO-381070:r:IRE1alpha activates chaperones", "R-GGA-451478:r:ERK activation", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-381070:r:IRE1alpha activates chaperones", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-CEL-201688:r:WNT mediated activation of DVL", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-RNO-422356:r:Regulation of insulin secretion", "R-SPO-2871837:r:FCERI mediated NF-kB activation", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-9634597:r:GPER1 signaling", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-MMU-5632684:r:Hedgehog 'on' state", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-XTR-5357905:r:Regulation of TNFR1 signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DDI-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-9664873:r:Pexophagy", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-191650:r:Regulation of gap junction activity", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5578768:r:Physiological factors", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-216083:r:Integrin cell surface interactions", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-9717264:r:ASP-3026-resistant ALK mutants", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-BTA-445355:r:Smooth Muscle Contraction", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DME-76005:r:Response to elevated platelet cytosolic Ca2+", "R-GGA-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9616222:r:Transcriptional regulation of granulopoiesis", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-SPO-1632852:r:Macroautophagy", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-114516:r:Disinhibition of SNARE formation", "R-SPO-6811555:r:PI5P Regulates TP53 Acetylation", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-198693:r:AKT phosphorylates targets in the nucleus", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DDI-165181:r:Inhibition of TSC complex formation by PKB", "R-XTR-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-201451:r:Signaling by BMP", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-DRE-1059683:r:Interleukin-6 signaling", "R-DME-4086398:r:Ca2+ pathway", "R-MMU-5674499:r:Negative feedback regulation of MAPK pathway", "R-CEL-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-GGA-1227739:r:Caspase-8 and -10 mediated induction of NF-kB", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-CEL-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-DRE-4419969:r:Depolymerization of the Nuclear Lamina", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9652817:r:Signaling by MAPK mutants", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SSC-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-RNO-9766229:r:Degradation of CDH1", "R-SPO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-RNO-68949:r:Orc1 removal from chromatin", "R-PFA-8963896:r:HDL assembly", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-RNO-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-180024:r:DARPP-32 events", "R-DME-166208:r:mTORC1-mediated signalling", "R-DRE-5675221:r:Negative regulation of MAPK pathway", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-DDI-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-DDI-198693:r:AKT phosphorylates targets in the nucleus", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-72086:r:mRNA Capping", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-8963896:r:HDL assembly", "R-SSC-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-BTA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-1483191:r:Synthesis of PC", "R-DME-201688:r:WNT mediated activation of DVL", "R-CEL-75153:r:Apoptotic execution phase", "R-PFA-5675482:r:Regulation of necroptotic cell death", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-8866376:r:Reelin signalling pathway", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-156711:r:Polo-like kinase mediated events", "R-BTA-5621480:r:Dectin-2 family", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-69541:r:Stabilization of p53", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-202424:r:Downstream TCR signaling", "R-HSA-9702600:r:midostaurin-resistant FLT3 mutants", "R-DRE-9758274:r:Regulation of NF-kappa B signaling", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-69541:r:Stabilization of p53", "R-PFA-5357905:r:Regulation of TNFR1 signaling", "R-DDI-156711:r:Polo-like kinase mediated events", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-DME-422356:r:Regulation of insulin secretion", "R-BTA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-XTR-202424:r:Downstream TCR signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-SCE-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-73728:r:RNA Polymerase I Promoter Opening", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-DME-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-449836:r:Other interleukin signaling", "R-GGA-9031628:r:NGF-stimulated transcription", "R-RNO-69563:r:p53-Dependent G1 DNA Damage Response", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-RNO-5673000:r:RAF activation", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-CEL-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-PFA-5673000:r:RAF activation", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-DME-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-SPO-2465910:r:MASTL Facilitates Mitotic Progression", "R-GGA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-937039:r:IRAK1 recruits IKK complex", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-CEL-1489509:r:DAG and IP3 signaling", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-BTA-375165:r:NCAM signaling for neurite out-growth", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9717316:r:alectinib-resistant ALK mutants", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9664873:r:Pexophagy", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-163615:r:PKA activation", "R-MMU-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-2029481:r:FCGR activation", "R-MMU-3928664:r:Ephrin signaling", "R-DDI-1632852:r:Macroautophagy", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-CEL-69473:r:G2/M DNA damage checkpoint", "R-BTA-3928664:r:Ephrin signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-MMU-164378:r:PKA activation in glucagon signalling", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-8875656:r:MET receptor recycling", "R-SPO-68949:r:Orc1 removal from chromatin", "R-RNO-450341:r:Activation of the AP-1 family of transcription factors", "R-BTA-8878166:r:Transcriptional regulation by RUNX2", "R-BTA-201688:r:WNT mediated activation of DVL", "R-XTR-5676590:r:NIK-->noncanonical NF-kB signaling", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-69231:r:Cyclin D associated events in G1", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-MMU-8935690:r:Digestion", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-GGA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-BTA-8849470:r:PTK6 Regulates Cell Cycle", "R-BTA-381042:r:PERK regulates gene expression", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-69563:r:p53-Dependent G1 DNA Damage Response", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68911:r:G2 Phase", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-203615:r:eNOS activation", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-BTA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DDI-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-381042:r:PERK regulates gene expression", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-DRE-190373:r:FGFR1c ligand binding and activation", "R-DME-8878166:r:Transcriptional regulation by RUNX2", "R-CFA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-432142:r:Platelet sensitization by LDL", "R-DRE-210990:r:PECAM1 interactions", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-74752:r:Signaling by Insulin receptor", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-69231:r:Cyclin D associated events in G1", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-DME-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-416476:r:G alpha (q) signalling events", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9702509:r:FLT3 mutants bind TKIs", "R-BTA-2142789:r:Ubiquinol biosynthesis", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-SCE-1489509:r:DAG and IP3 signaling", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-SPO-432142:r:Platelet sensitization by LDL", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-DME-165159:r:MTOR signalling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9702581:r:crenolanib-resistant FLT3 mutants", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1227986:r:Signaling by ERBB2", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-68875:r:Mitotic Prophase", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-DDI-110056:r:MAPK3 (ERK1) activation", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-2028269:r:Signaling by Hippo", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-CFA-201556:r:Signaling by ALK", "R-HSA-9022535:r:Loss of phosphorylation of MECP2 at T308", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DDI-9634597:r:GPER1 signaling", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-68875:r:Mitotic Prophase", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-MMU-1502540:r:Signaling by Activin", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-MMU-74713:r:IRS activation", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-DME-5218900:r:CASP8 activity is inhibited", "R-CEL-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-GGA-392517:r:Rap1 signalling", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-CEL-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-3928664:r:Ephrin signaling", "R-CEL-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-CEL-9007892:r:Interleukin-38 signaling", "R-DDI-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-DME-6794361:r:Neurexins and neuroligins", "R-XTR-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-RNO-9020702:r:Interleukin-1 signaling", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-9619229:r:Activation of RAC1 downstream of NMDARs", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8875791:r:MET activates STAT3", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-69478:r:G2/M DNA replication checkpoint", "R-SPO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-68911:r:G2 Phase", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-BTA-8853659:r:RET signaling", "R-DDI-8953750:r:Transcriptional Regulation by E2F6", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-DDI-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-DME-5674135:r:MAP2K and MAPK activation", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-DRE-418594:r:G alpha (i) signalling events", "R-SSC-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9632697:r:Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4", "R-HSA-3928664:r:Ephrin signaling", "R-CEL-68884:r:Mitotic Telophase/Cytokinesis", "R-CEL-1912408:r:Pre-NOTCH Transcription and Translation", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-SCE-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-199920:r:CREB phosphorylation", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SSC-1632852:r:Macroautophagy", "R-DDI-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-68911:r:G2 Phase", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-CEL-419037:r:NCAM1 interactions", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-176417:r:Phosphorylation of Emi1", "R-MMU-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-CEL-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DME-525793:r:Myogenesis", "R-XTR-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DDI-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-9702614:r:ponatinib-resistant FLT3 mutants", "R-MMU-198203:r:PI3K/AKT activation", "R-GGA-198753:r:ERK/MAPK targets", "R-DRE-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-BTA-201556:r:Signaling by ALK", "R-CFA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-8849473:r:PTK6 Expression", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-9634597:r:GPER1 signaling", "R-SCE-9013424:r:RHOV GTPase cycle", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-GGA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-SCE-72086:r:mRNA Capping", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-982772:r:Growth hormone receptor signaling", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-SCE-4086398:r:Ca2+ pathway", "R-DME-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-525793:r:Myogenesis", "R-CEL-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-1236394:r:Signaling by ERBB4", "R-SSC-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-390522:r:Striated Muscle Contraction", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9020702:r:Interleukin-1 signaling", "R-DME-877300:r:Interferon gamma signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-2179392:r:EGFR Transactivation by Gastrin", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-MMU-3000170:r:Syndecan interactions", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-XTR-114516:r:Disinhibition of SNARE formation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-CEL-112409:r:RAF-independent MAPK1/3 activation", "R-CEL-165159:r:MTOR signalling", "R-DME-3928664:r:Ephrin signaling", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-SPO-389359:r:CD28 dependent Vav1 pathway", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-69231:r:Cyclin D associated events in G1", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-77387:r:Insulin receptor recycling", "R-DME-538898:r:Dephosphorylation of TIM", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-PFA-5610787:r:Hedgehog 'off' state", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-SCE-69473:r:G2/M DNA damage checkpoint", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SCE-1483191:r:Synthesis of PC", "R-RNO-198765:r:Signalling to ERK5", "R-BTA-399719:r:Trafficking of AMPA receptors", "R-SSC-6806942:r:MET Receptor Activation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-CEL-199418:r:Negative regulation of the PI3K/AKT network", "R-BTA-69478:r:G2/M DNA replication checkpoint", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-GGA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-DME-1502540:r:Signaling by Activin", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-201451:r:Signaling by BMP", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-1181150:r:Signaling by NODAL", "R-HSA-68877:r:Mitotic Prometaphase", "R-CFA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-RNO-5674499:r:Negative feedback regulation of MAPK pathway", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9020558:r:Interleukin-2 signaling", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-912631:r:Regulation of signaling by CBL", "R-BTA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-8875791:r:MET activates STAT3", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SPO-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-198765:r:Signalling to ERK5", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-BTA-9607240:r:FLT3 Signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-CEL-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-8939211:r:ESR-mediated signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-114604:r:GPVI-mediated activation cascade", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-CEL-198753:r:ERK/MAPK targets", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SPO-200425:r:Carnitine shuttle", "R-HSA-164944:r:Nef and signal transduction", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-BTA-877300:r:Interferon gamma signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-MMU-420029:r:Tight junction interactions", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-GGA-5621480:r:Dectin-2 family", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-DRE-210993:r:Tie2 Signaling", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-111995:r:phospho-PLA2 pathway", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-163615:r:PKA activation", "R-PFA-163615:r:PKA activation", "R-CEL-5627123:r:RHO GTPases activate PAKs", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-9968551:r:Regulation of GBP-mediated host defense", "R-RNO-1632852:r:Macroautophagy", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-71064:r:Lysine catabolism", "R-RNO-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DRE-5621480:r:Dectin-2 family", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-BTA-9634597:r:GPER1 signaling", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-DME-1433559:r:Regulation of KIT signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-RNO-2029481:r:FCGR activation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-CFA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-CFA-432142:r:Platelet sensitization by LDL", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-432620:r:Dephosphorylation of PER", "R-HSA-1433559:r:Regulation of KIT signaling", "R-CEL-112411:r:MAPK1 (ERK2) activation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-418597:r:G alpha (z) signalling events", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-SSC-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-110523:r:TOR signaling pathway", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-SPO-1483191:r:Synthesis of PC", "R-PFA-171007:r:p38MAPK events", "R-HSA-9664873:r:Pexophagy", "R-SSC-1227986:r:Signaling by ERBB2", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-176417:r:Phosphorylation of Emi1", "R-HSA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-198765:r:Signalling to ERK5", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-SPO-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-8983711:r:OAS antiviral response", "R-SSC-1059683:r:Interleukin-6 signaling", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-SPO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-381070:r:IRE1alpha activates chaperones", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-9717326:r:crizotinib-resistant ALK mutants", "R-HSA-74752:r:Signaling by Insulin receptor", "R-BTA-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-SSC-8865999:r:MET activates PTPN11", "R-MMU-525793:r:Myogenesis", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-3000170:r:Syndecan interactions", "R-SPO-198765:r:Signalling to ERK5", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DDI-2028269:r:Signaling by Hippo", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DME-9013420:r:RHOU GTPase cycle", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-CEL-176187:r:Activation of ATR in response to replication stress", "R-DDI-8934903:r:Receptor Mediated Mitophagy", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-RNO-112399:r:IRS-mediated signalling", "R-GGA-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-DRE-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-CEL-190322:r:FGFR4 ligand binding and activation", "R-SCE-5610787:r:Hedgehog 'off' state", "R-DME-112409:r:RAF-independent MAPK1/3 activation", "R-DME-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-DRE-9013106:r:RHOC GTPase cycle", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DME-69473:r:G2/M DNA damage checkpoint", "R-MMU-8853659:r:RET signaling", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-77387:r:Insulin receptor recycling", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-170968:r:Frs2-mediated activation", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-DME-354192:r:Integrin signaling", "R-DME-110478:r:Insulin signaling pathway", "R-DRE-177929:r:Signaling by EGFR", "R-HSA-9620244:r:Long-term potentiation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-418555:r:G alpha (s) signalling events", "R-DME-418592:r:ADP signalling through P2Y purinoceptor 1", "R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-389356:r:Co-stimulation by CD28", "R-DDI-198323:r:AKT phosphorylates targets in the cytosol", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-SPO-450341:r:Activation of the AP-1 family of transcription factors", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-525793:r:Myogenesis", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-RNO-9648002:r:RAS processing", "R-HSA-171007:r:p38MAPK events", "R-DME-450341:r:Activation of the AP-1 family of transcription factors", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-GGA-210990:r:PECAM1 interactions", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-SCE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-CEL-418594:r:G alpha (i) signalling events", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-SCE-203615:r:eNOS activation", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5689603:r:UCH proteinases", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-449836:r:Other interleukin signaling", "R-SPO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-6782135:r:Dual incision in TC-NER", "R-RNO-111933:r:Calmodulin induced events", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DRE-444257:r:RSK activation", "R-HSA-418885:r:DCC mediated attractive signaling", "R-BTA-114516:r:Disinhibition of SNARE formation", "R-DME-381042:r:PERK regulates gene expression", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-CFA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SPO-114604:r:GPVI-mediated activation cascade", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-PFA-9833482:r:PKR-mediated signaling", "R-RNO-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-SPO-525793:r:Myogenesis", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-DRE-9013408:r:RHOG GTPase cycle", "R-SSC-1433559:r:Regulation of KIT signaling", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-SPO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-5610787:r:Hedgehog 'off' state", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-211163:r:AKT-mediated inactivation of FOXO1A", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-198203:r:PI3K/AKT activation", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-HSA-203615:r:eNOS activation", "R-DME-68962:r:Activation of the pre-replicative complex", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-BTA-68875:r:Mitotic Prophase", "R-SSC-210990:r:PECAM1 interactions", "R-CEL-4086398:r:Ca2+ pathway", "R-SPO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-1236394:r:Signaling by ERBB4", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-170984:r:ARMS-mediated activation", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-69478:r:G2/M DNA replication checkpoint", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-392517:r:Rap1 signalling", "R-SPO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-SPO-5610787:r:Hedgehog 'off' state", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-203615:r:eNOS activation", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-DME-216083:r:Integrin cell surface interactions", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-69416:r:Dimerization of procaspase-8", "R-SCE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-XTR-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-DRE-9013026:r:RHOB GTPase cycle", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DDI-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-SCE-114604:r:GPVI-mediated activation cascade", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CEL-2024096:r:HS-GAG degradation", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-68884:r:Mitotic Telophase/Cytokinesis", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-201451:r:Signaling by BMP", "R-CEL-164378:r:PKA activation in glucagon signalling", "R-CEL-171007:r:p38MAPK events", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9706369:r:Negative regulation of FLT3", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-9833482:r:PKR-mediated signaling", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-BTA-180292:r:GAB1 signalosome", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DRE-420029:r:Tight junction interactions", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-8934903:r:Receptor Mediated Mitophagy", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9842663:r:Signaling by LTK", "R-SPO-180024:r:DARPP-32 events", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CEL-2672351:r:Stimuli-sensing channels", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-877300:r:Interferon gamma signaling", "R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-DRE-1266695:r:Interleukin-7 signaling", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-BTA-9627069:r:Regulation of the apoptosome activity", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-170968:r:Frs2-mediated activation", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-DME-3371571:r:HSF1-dependent transactivation", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-XTR-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-GGA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-418555:r:G alpha (s) signalling events", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-SPO-1483213:r:Synthesis of PE", "R-HSA-3642279:r:TGFBR2 MSI Frameshift Mutants in Cancer", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-SPO-156711:r:Polo-like kinase mediated events", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-BTA-2028269:r:Signaling by Hippo", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-1489509:r:DAG and IP3 signaling", "R-CEL-1632852:r:Macroautophagy", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-418885:r:DCC mediated attractive signaling", "R-RNO-2672351:r:Stimuli-sensing channels", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DME-209159:r:Assembly of the CI containing complexes", "R-BTA-5654732:r:Negative regulation of FGFR3 signaling", "R-DDI-2871796:r:FCERI mediated MAPK activation", "R-DDI-164378:r:PKA activation in glucagon signalling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-PFA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-163358:r:PKA-mediated phosphorylation of key metabolic factors", "R-HSA-354192:r:Integrin signaling", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SSC-6807004:r:Negative regulation of MET activity", "R-MMU-156711:r:Polo-like kinase mediated events", "R-SSC-9020956:r:Interleukin-27 signaling", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-6794361:r:Neurexins and neuroligins", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-68877:r:Mitotic Prometaphase", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-389356:r:Co-stimulation by CD28", "R-HSA-1236394:r:Signaling by ERBB4", "R-BTA-1433559:r:Regulation of KIT signaling", "R-MMU-8963896:r:HDL assembly", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-422356:r:Regulation of insulin secretion", "R-DRE-1295596:r:Spry regulation of FGF signaling", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-176417:r:Phosphorylation of Emi1", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-XTR-1169091:r:Activation of NF-kappaB in B cells", "R-DRE-71064:r:Lysine catabolism", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-DDI-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-373753:r:Nephrin family interactions", "R-CEL-201556:r:Signaling by ALK", "R-DDI-444257:r:RSK activation", "R-MMU-180292:r:GAB1 signalosome", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-210993:r:Tie2 Signaling", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-DDI-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-196299:r:Beta-catenin phosphorylation cascade", "R-SPO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DRE-354192:r:Integrin signaling", "R-XTR-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-5635838:r:Activation of SMO", "R-DME-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-8854521:r:Interaction between PHLDA1 and AURKA", "R-SPO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-DDI-9031628:r:NGF-stimulated transcription", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-1489509:r:DAG and IP3 signaling", "R-BTA-5673000:r:RAF activation", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-BTA-5654726:r:Negative regulation of FGFR1 signaling", "R-SCE-6782135:r:Dual incision in TC-NER", "R-RNO-432142:r:Platelet sensitization by LDL", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-109704:r:PI3K Cascade", "R-BTA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-RNO-68881:r:Mitotic Metaphase/Anaphase Transition", "R-RNO-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-CEL-68911:r:G2 Phase", "R-HSA-525793:r:Myogenesis", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-389948:r:Co-inhibition by PD-1", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-9645135:r:STAT5 Activation", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-GGA-389356:r:Co-stimulation by CD28", "R-SCE-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-DME-180024:r:DARPP-32 events", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DME-209397:r:Formation of the cytosolic BSK 'scaffolding complex'", "R-DDI-8963896:r:HDL assembly", "R-DDI-202670:r:ERKs are inactivated", "R-BTA-180024:r:DARPP-32 events", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-5603027:r:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "R-CEL-5578775:r:Ion homeostasis", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-8875656:r:MET receptor recycling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-DME-176417:r:Phosphorylation of Emi1", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-418885:r:DCC mediated attractive signaling", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-186797:r:Signaling by PDGF", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-1483213:r:Synthesis of PE", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-BTA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-5673000:r:RAF activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-8854521:r:Interaction between PHLDA1 and AURKA", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5673000:r:RAF activation", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DDI-445144:r:Signal transduction by L1", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-DME-390023:r:Subcellular localisation of D", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-XTR-176417:r:Phosphorylation of Emi1", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SPO-9031628:r:NGF-stimulated transcription", "R-SSC-389356:r:Co-stimulation by CD28", "R-RNO-210993:r:Tie2 Signaling", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-MMU-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-MMU-9031628:r:NGF-stimulated transcription", "R-BTA-450341:r:Activation of the AP-1 family of transcription factors", "R-CEL-9648002:r:RAS processing", "R-DME-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-PFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-GGA-199920:r:CREB phosphorylation", "R-DRE-430116:r:GP1b-IX-V activation signalling", "R-HSA-9703009:r:tamatinib-resistant FLT3 mutants", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-1502540:r:Signaling by Activin", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-DME-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-68884:r:Mitotic Telophase/Cytokinesis", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-DME-418555:r:G alpha (s) signalling events", "R-CFA-9851151:r:MDK and PTN in ALK signaling", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-CEL-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-HSA-4086398:r:Ca2+ pathway", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SPO-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-216119:r:Activation of CI", "R-CEL-193648:r:NRAGE signals death through JNK", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-XTR-1295596:r:Spry regulation of FGF signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-109704:r:PI3K Cascade", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-MMU-176417:r:Phosphorylation of Emi1", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-SSC-8875555:r:MET activates RAP1 and RAC1", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-392517:r:Rap1 signalling", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-198753:r:ERK/MAPK targets", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-XTR-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-PFA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-201556:r:Signaling by ALK", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-HSA-9702569:r:KW2449-resistant FLT3 mutants", "R-CEL-166208:r:mTORC1-mediated signalling", "R-MMU-74749:r:Signal attenuation", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-CEL-912631:r:Regulation of signaling by CBL", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-MMU-69541:r:Stabilization of p53", "R-MMU-381042:r:PERK regulates gene expression", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-392517:r:Rap1 signalling", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-1433559:r:Regulation of KIT signaling", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-BTA-2514853:r:Condensation of Prometaphase Chromosomes", "R-DME-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-MMU-8939211:r:ESR-mediated signaling", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-199920:r:CREB phosphorylation", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SSC-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-72086:r:mRNA Capping", "R-PFA-5213460:r:RIPK1-mediated regulated necrosis", "R-BTA-912631:r:Regulation of signaling by CBL", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-420029:r:Tight junction interactions", "R-MMU-69478:r:G2/M DNA replication checkpoint", "R-DRE-5654710:r:PI-3K cascade:FGFR3", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-GGA-450341:r:Activation of the AP-1 family of transcription factors", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-DME-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SPO-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-201688:r:WNT mediated activation of DVL", "R-MMU-203615:r:eNOS activation", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-72086:r:mRNA Capping", "R-DDI-176187:r:Activation of ATR in response to replication stress", "R-MMU-9619229:r:Activation of RAC1 downstream of NMDARs", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-SSC-2559585:r:Oncogene Induced Senescence", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CFA-1433559:r:Regulation of KIT signaling", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-9013106:r:RHOC GTPase cycle", "R-SCE-381070:r:IRE1alpha activates chaperones", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9652169:r:Signaling by MAP2K mutants", "R-SSC-399956:r:CRMPs in Sema3A signaling", "R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-392517:r:Rap1 signalling", "R-CEL-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-RNO-8935690:r:Digestion", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-SCE-198765:r:Signalling to ERK5", "R-SCE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-HSA-176034:r:Interactions of Tat with host cellular proteins", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-DRE-416476:r:G alpha (q) signalling events", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-MMU-9008059:r:Interleukin-37 signaling", "R-HSA-2028269:r:Signaling by Hippo", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-3295583:r:TRP channels", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-RNO-190322:r:FGFR4 ligand binding and activation", "R-CEL-444257:r:RSK activation", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-BTA-5689880:r:Ub-specific processing proteases", "R-RNO-1483191:r:Synthesis of PC", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-HSA-198745:r:Signalling to STAT3", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-CEL-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-2559585:r:Oncogene Induced Senescence", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-BTA-210990:r:PECAM1 interactions", "R-SSC-912631:r:Regulation of signaling by CBL", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-SCE-166208:r:mTORC1-mediated signalling", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-202670:r:ERKs are inactivated", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-168638:r:NOD1/2 Signaling Pathway", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-1632852:r:Macroautophagy", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-DRE-1227986:r:Signaling by ERBB2", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-68911:r:G2 Phase", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-9634597:r:GPER1 signaling", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-BTA-982772:r:Growth hormone receptor signaling", "R-BTA-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-SSC-373753:r:Nephrin family interactions", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-2672351:r:Stimuli-sensing channels", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-HSA-912446:r:Meiotic recombination", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-381070:r:IRE1alpha activates chaperones", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-CEL-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-112399:r:IRS-mediated signalling", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-DME-9614399:r:Regulation of localization of FOXO transcription factors", "R-BTA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-9604323:r:Negative regulation of NOTCH4 signaling", "R-PFA-164378:r:PKA activation in glucagon signalling", "R-GGA-9732724:r:IFNG signaling activates MAPKs", "R-DDI-8854214:r:TBC/RABGAPs", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-216217:r:Activation of SMO", "R-RNO-9020558:r:Interleukin-2 signaling", "R-SCE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DME-9020558:r:Interleukin-2 signaling", "R-SCE-450341:r:Activation of the AP-1 family of transcription factors", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-GGA-354192:r:Integrin signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-MMU-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-DME-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-139910:r:Activation of BMF and translocation to mitochondria", "R-DME-209459:r:Imd pathway", "R-CEL-389359:r:CD28 dependent Vav1 pathway", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-74713:r:IRS activation", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-GGA-375165:r:NCAM signaling for neurite out-growth", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-BTA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-BTA-8980692:r:RHOA GTPase cycle", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-GGA-5673000:r:RAF activation", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-191650:r:Regulation of gap junction activity", "R-RNO-69478:r:G2/M DNA replication checkpoint", "R-DME-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-CEL-381042:r:PERK regulates gene expression", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-XTR-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-69416:r:Dimerization of procaspase-8", "R-BTA-5578775:r:Ion homeostasis", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-DME-165181:r:Inhibition of TSC complex formation by PKB", "R-DME-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-PFA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-DME-177929:r:Signaling by EGFR", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-BTA-418457:r:cGMP effects", "R-RNO-74713:r:IRS activation", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-9664873:r:Pexophagy", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-198753:r:ERK/MAPK targets", "R-RNO-111446:r:Activation of BIM and translocation to mitochondria", "R-RNO-68884:r:Mitotic Telophase/Cytokinesis", "R-PFA-9634597:r:GPER1 signaling", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SSC-9020591:r:Interleukin-12 signaling", "R-CEL-8980692:r:RHOA GTPase cycle", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-XTR-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2029481:r:FCGR activation", "R-SPO-202424:r:Downstream TCR signaling", "R-RNO-8983432:r:Interleukin-15 signaling", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-170968:r:Frs2-mediated activation", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9007892:r:Interleukin-38 signaling", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-DME-201681:r:TCF dependent signaling in response to WNT", "R-DRE-198753:r:ERK/MAPK targets", "R-HSA-212436:r:Generic Transcription Pathway", "R-DME-5673000:r:RAF activation", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-XTR-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SPO-165158:r:Activation of AKT2", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-MMU-5635838:r:Activation of SMO", "R-DRE-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-SCE-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-373753:r:Nephrin family interactions", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-SCE-445144:r:Signal transduction by L1", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-CFA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-CEL-186763:r:Downstream signal transduction", "R-XTR-68884:r:Mitotic Telophase/Cytokinesis", "R-BTA-354192:r:Integrin signaling", "R-HSA-165160:r:PDE3B signalling", "R-SCE-2871796:r:FCERI mediated MAPK activation", "R-SSC-8878166:r:Transcriptional regulation by RUNX2", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-DDI-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-SPO-198753:r:ERK/MAPK targets", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-DRE-912631:r:Regulation of signaling by CBL", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-RNO-1059683:r:Interleukin-6 signaling", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-BTA-8854521:r:Interaction between PHLDA1 and AURKA", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-HSA-450341:r:Activation of the AP-1 family of transcription factors", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-DDI-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-XTR-9833482:r:PKR-mediated signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SSC-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-CFA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SCE-156711:r:Polo-like kinase mediated events", "R-MMU-9696273:r:RND1 GTPase cycle", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-2871837:r:FCERI mediated NF-kB activation", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-SCE-1483248:r:Synthesis of PIPs at the ER membrane", "R-DRE-69231:r:Cyclin D associated events in G1", "R-DME-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-877300:r:Interferon gamma signaling", "R-BTA-112399:r:IRS-mediated signalling", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-165158:r:Activation of AKT2", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-165159:r:MTOR signalling", "R-BTA-2980766:r:Nuclear Envelope Breakdown", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-DRE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-171319:r:Telomere Extension By Telomerase", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-1632852:r:Macroautophagy", "R-MMU-76005:r:Response to elevated platelet cytosolic Ca2+", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-DDI-5625740:r:RHO GTPases activate PKNs", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-HSA-9632700:r:Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6", "R-BTA-198765:r:Signalling to ERK5", "R-HSA-3371378:r:Regulation by c-FLIP", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-SCE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-PFA-5689880:r:Ub-specific processing proteases", "R-SPO-163615:r:PKA activation", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-211736:r:Stimulation of the cell death response by PAK-2p34", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-877312:r:Regulation of IFNG signaling", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-DDI-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-8852405:r:Signaling by MST1", "R-DME-163615:r:PKA activation", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-75153:r:Apoptotic execution phase", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-180024:r:DARPP-32 events", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-171007:r:p38MAPK events", "R-HSA-216083:r:Integrin cell surface interactions", "R-DDI-3295583:r:TRP channels", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-5578775:r:Ion homeostasis", "R-RNO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-SPO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-HSA-111995:r:phospho-PLA2 pathway", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-SSC-200425:r:Carnitine shuttle", "R-SCE-114508:r:Effects of PIP2 hydrolysis", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-8939211:r:ESR-mediated signaling", "R-RNO-9839406:r:TGFBR3 regulates activin signaling", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-XTR-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-3928664:r:Ephrin signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-1483191:r:Synthesis of PC", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DRE-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-202433:r:Generation of second messenger molecules", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-525793:r:Myogenesis", "R-HSA-6806942:r:MET Receptor Activation", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-DRE-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-390150:r:DS ligand bound to FT receptor", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-68881:r:Mitotic Metaphase/Anaphase Transition", "R-SPO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-MMU-1489509:r:DAG and IP3 signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-CFA-112411:r:MAPK1 (ERK2) activation", "R-SPO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-5578768:r:Physiological factors", "R-HSA-198753:r:ERK/MAPK targets", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-CEL-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-9702590:r:gilteritinib-resistant FLT3 mutants", "R-RNO-180024:r:DARPP-32 events", "R-DDI-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-69416:r:Dimerization of procaspase-8", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-9648002:r:RAS processing", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-389359:r:CD28 dependent Vav1 pathway", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-SPO-2871796:r:FCERI mediated MAPK activation", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9931529:r:Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK", "R-DDI-69202:r:Cyclin E associated events during G1/S transition", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-BTA-2424491:r:DAP12 signaling", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SSC-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-8849470:r:PTK6 Regulates Cell Cycle", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-CEL-9616222:r:Transcriptional regulation of granulopoiesis", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-DME-209396:r:Phosphorylation of ARM", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DME-209387:r:Phosphorylation of ARR", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SSC-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-9702636:r:tandutinib-resistant FLT3 mutants", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-XTR-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-1170546:r:Prolactin receptor signaling", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-SPO-114508:r:Effects of PIP2 hydrolysis", "R-DDI-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-PFA-9837999:r:Mitochondrial protein degradation", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-HSA-9717319:r:brigatinib-resistant ALK mutants", "R-CEL-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-203615:r:eNOS activation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-68884:r:Mitotic Telophase/Cytokinesis", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-450341:r:Activation of the AP-1 family of transcription factors", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-373752:r:Netrin-1 signaling", "R-CEL-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-HSA-73728:r:RNA Polymerase I Promoter Opening", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-BTA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-SPO-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-CEL-110056:r:MAPK3 (ERK1) activation", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-6783783:r:Interleukin-10 signaling", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-75893:r:TNF signaling", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-1236394:r:Signaling by ERBB4", "R-DRE-432142:r:Platelet sensitization by LDL", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-CEL-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-445144:r:Signal transduction by L1", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-GGA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9702998:r:linifanib-resistant FLT3 mutants", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-190370:r:FGFR1b ligand binding and activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-422356:r:Regulation of insulin secretion", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DDI-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-RNO-3295583:r:TRP channels", "R-CFA-5674135:r:MAP2K and MAPK activation", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-RNO-373752:r:Netrin-1 signaling", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-DRE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-170984:r:ARMS-mediated activation", "R-RNO-8932505:r:DAG1 core M3 glycosylations", "R-HSA-211163:r:AKT-mediated inactivation of FOXO1A", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DDI-112411:r:MAPK1 (ERK2) activation", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-201688:r:WNT mediated activation of DVL", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-112409:r:RAF-independent MAPK1/3 activation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SSC-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-75153:r:Apoptotic execution phase", "R-SPO-203615:r:eNOS activation", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-XTR-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SSC-8875791:r:MET activates STAT3", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-373753:r:Nephrin family interactions", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-432142:r:Platelet sensitization by LDL", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-DDI-180024:r:DARPP-32 events", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-HSA-420029:r:Tight junction interactions", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-912631:r:Regulation of signaling by CBL", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-CFA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-CEL-202670:r:ERKs are inactivated", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-SCE-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-9664873:r:Pexophagy", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-8866376:r:Reelin signalling pathway", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-164378:r:PKA activation in glucagon signalling", "R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DME-210991:r:Basigin interactions", "R-GGA-9839406:r:TGFBR3 regulates activin signaling", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-1538133:r:G0 and Early G1", "R-CEL-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9008059:r:Interleukin-37 signaling", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-CEL-6782135:r:Dual incision in TC-NER", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-BTA-164378:r:PKA activation in glucagon signalling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-170984:r:ARMS-mediated activation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-68911:r:G2 Phase", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SCE-429947:r:Deadenylation of mRNA", "R-HSA-9702620:r:quizartinib-resistant FLT3 mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-191650:r:Regulation of gap junction activity", "R-SPO-69473:r:G2/M DNA damage checkpoint", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-SPO-166208:r:mTORC1-mediated signalling", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-418457:r:cGMP effects", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-CEL-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9717329:r:lorlatinib-resistant ALK mutants", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-DDI-163615:r:PKA activation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-432490:r:Nuclear import of PER and TIM", "R-CEL-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-202670:r:ERKs are inactivated", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-CEL-2871796:r:FCERI mediated MAPK activation", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DDI-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DRE-9851151:r:MDK and PTN in ALK signaling", "R-RNO-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-1483213:r:Synthesis of PE", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-DME-9833482:r:PKR-mediated signaling", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-XTR-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DDI-4086398:r:Ca2+ pathway", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-1433559:r:Regulation of KIT signaling", "R-SCE-163615:r:PKA activation", "R-MMU-111995:r:phospho-PLA2 pathway", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-BTA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-BTA-202670:r:ERKs are inactivated", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-9634597:r:GPER1 signaling", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9717301:r:NVP-TAE684-resistant ALK mutants", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-DME-68875:r:Mitotic Prophase", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-CEL-450341:r:Activation of the AP-1 family of transcription factors", "R-CEL-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9630791:r:Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-BTA-156711:r:Polo-like kinase mediated events", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DRE-9020702:r:Interleukin-1 signaling", "R-DRE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-RNO-8865999:r:MET activates PTPN11", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-CEL-525793:r:Myogenesis", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-CEL-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-SCE-432142:r:Platelet sensitization by LDL", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5578768:r:Physiological factors", "R-CEL-180292:r:GAB1 signalosome", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-SSC-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-MMU-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-CEL-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-DDI-203615:r:eNOS activation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-5674499:r:Negative feedback regulation of MAPK pathway", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-381042:r:PERK regulates gene expression", "R-RNO-6794361:r:Neurexins and neuroligins", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-XTR-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-444257:r:RSK activation", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-DRE-9842663:r:Signaling by LTK", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-DDI-69473:r:G2/M DNA damage checkpoint", "R-CEL-1502540:r:Signaling by Activin", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-5578768:r:Physiological factors", "R-BTA-186763:r:Downstream signal transduction", "R-BTA-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DRE-449836:r:Other interleukin signaling", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-2465910:r:MASTL Facilitates Mitotic Progression", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-171007:r:p38MAPK events", "R-DME-170968:r:Frs2-mediated activation", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-RNO-186797:r:Signaling by PDGF", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-RNO-9007892:r:Interleukin-38 signaling", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-444257:r:RSK activation", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-2514853:r:Condensation of Prometaphase Chromosomes", "R-SCE-444257:r:RSK activation", "R-SSC-8875656:r:MET receptor recycling", "R-SPO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-210993:r:Tie2 Signaling", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-2299718:r:Condensation of Prophase Chromosomes", "R-DDI-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-MMU-8854214:r:TBC/RABGAPs", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9702632:r:sunitinib-resistant FLT3 mutants", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-3371378:r:Regulation by c-FLIP", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-CEL-3000170:r:Syndecan interactions", "R-SPO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-209209:r:Formation of the activated receptor complex", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-SCE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-PFA-5689896:r:Ovarian tumor domain proteases", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-PFA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DRE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-202670:r:ERKs are inactivated", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-CEL-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-CFA-198753:r:ERK/MAPK targets", "R-CEL-180024:r:DARPP-32 events", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-164378:r:PKA activation in glucagon signalling", "R-DME-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-DME-112411:r:MAPK1 (ERK2) activation", "R-DME-1632852:r:Macroautophagy", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-201451:r:Signaling by BMP", "R-DDI-3899300:r:SUMOylation of transcription cofactors", "R-BTA-202433:r:Generation of second messenger molecules", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DME-392517:r:Rap1 signalling", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-354192:r:Integrin signaling", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-373752:r:Netrin-1 signaling", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-1538133:r:G0 and Early G1", "R-BTA-437239:r:Recycling pathway of L1", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-418457:r:cGMP effects", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-BTA-1538133:r:G0 and Early G1", "R-DRE-9031628:r:NGF-stimulated transcription", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-71064:r:Lysine catabolism", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-936837:r:Ion transport by P-type ATPases", "R-RNO-139910:r:Activation of BMF and translocation to mitochondria", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-156711:r:Polo-like kinase mediated events", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-176412:r:Phosphorylation of the APC/C", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-BTA-111933:r:Calmodulin induced events", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-75153:r:Apoptotic execution phase", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-SPO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-DRE-8874081:r:MET activates PTK2 signaling", "R-SCE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-444257:r:RSK activation", "R-HSA-187024:r:NGF-independant TRKA activation", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-SPO-75153:r:Apoptotic execution phase", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-186797:r:Signaling by PDGF", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-9020702:r:Interleukin-1 signaling", "R-BTA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-199920:r:CREB phosphorylation", "R-HSA-187042:r:TRKA activation by NGF", "R-BTA-9013424:r:RHOV GTPase cycle", "R-CEL-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-8866376:r:Reelin signalling pathway", "R-MMU-9020933:r:Interleukin-23 signaling", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DDI-9020702:r:Interleukin-1 signaling", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-9664873:r:Pexophagy", "R-SCE-9013420:r:RHOU GTPase cycle", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-CEL-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-1538133:r:G0 and Early G1", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-1227986:r:Signaling by ERBB2", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-9007892:r:Interleukin-38 signaling", "R-RNO-8853659:r:RET signaling", "R-CEL-177929:r:Signaling by EGFR", "R-CEL-9833482:r:PKR-mediated signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-PFA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-BTA-416476:r:G alpha (q) signalling events", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DME-399997:r:Acetylcholine regulates insulin secretion", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-1483191:r:Synthesis of PC", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-SPO-429947:r:Deadenylation of mRNA", "R-CEL-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-GGA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-CEL-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-SCE-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-68881:r:Mitotic Metaphase/Anaphase Transition", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DDI-381070:r:IRE1alpha activates chaperones", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-DME-77387:r:Insulin receptor recycling", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-432142:r:Platelet sensitization by LDL", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9830674:r:Formation of the ureteric bud", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-CEL-68949:r:Orc1 removal from chromatin", "R-SCE-525793:r:Myogenesis", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-176412:r:Phosphorylation of the APC/C", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-166208:r:mTORC1-mediated signalling", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-SCE-2871837:r:FCERI mediated NF-kB activation", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SCE-164378:r:PKA activation in glucagon signalling", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-CFA-450341:r:Activation of the AP-1 family of transcription factors", "R-CEL-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-RNO-2028269:r:Signaling by Hippo", "R-BTA-1227986:r:Signaling by ERBB2", "R-MMU-1632852:r:Macroautophagy", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-8963896:r:HDL assembly", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-PFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-PFA-180024:r:DARPP-32 events", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-DDI-198753:r:ERK/MAPK targets", "R-DME-211163:r:AKT-mediated inactivation of FOXO1A", "R-CEL-182971:r:EGFR downregulation", "R-SCE-200425:r:Carnitine shuttle", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-165159:r:MTOR signalling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-DME-9607240:r:FLT3 Signaling", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-170968:r:Frs2-mediated activation", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DRE-186763:r:Downstream signal transduction", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-RNO-202670:r:ERKs are inactivated", "R-DDI-111995:r:phospho-PLA2 pathway", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-389356:r:Co-stimulation by CD28", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-171007:r:p38MAPK events", "R-DME-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-390089:r:Formation of the Hippo kinase cassette", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-9013420:r:RHOU GTPase cycle", "R-CEL-9031628:r:NGF-stimulated transcription", "R-DME-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-198693:r:AKT phosphorylates targets in the nucleus", "R-RNO-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-DME-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-DRE-109704:r:PI3K Cascade", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9824272:r:Somitogenesis", "R-RNO-199920:r:CREB phosphorylation", "R-SCE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-166208:r:mTORC1-mediated signalling", "R-DRE-2142789:r:Ubiquinol biosynthesis", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-429947:r:Deadenylation of mRNA", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-111446:r:Activation of BIM and translocation to mitochondria", "R-DDI-112409:r:RAF-independent MAPK1/3 activation", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-SCE-75153:r:Apoptotic execution phase", "R-HSA-8852405:r:Signaling by MST1", "R-DRE-2028269:r:Signaling by Hippo", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-BTA-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DME-74749:r:Signal attenuation", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DDI-4419969:r:Depolymerization of the Nuclear Lamina", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1181150:r:Signaling by NODAL", "R-DDI-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-BTA-210993:r:Tie2 Signaling", "R-DME-9007892:r:Interleukin-38 signaling", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-193648:r:NRAGE signals death through JNK", "R-HSA-169131:r:Inhibition of PKR", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-HSA-68881:r:Mitotic Metaphase/Anaphase Transition", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-8866376:r:Reelin signalling pathway", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-8939211:r:ESR-mediated signaling", "R-BTA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DDI-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-187042:r:TRKA activation by NGF", "R-RNO-73728:r:RNA Polymerase I Promoter Opening", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-SPO-72086:r:mRNA Capping", "R-CEL-8854214:r:TBC/RABGAPs", "R-SSC-3371571:r:HSF1-dependent transactivation"], "type": "Homologous_superfamily"}, "IPR011010": {"description": "DNA breaking-rejoining enzyme, catalytic core", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "DNA_brk_join_enz", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-HSA-4615885", "R-SPO-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", 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"R-CEL-193648", "R-MMU-5693607", "R-BTA-8856828", "R-HSA-381038", "R-MMU-212676", "R-RNO-181430", "R-MMU-6804757", "R-HSA-3214842", "R-HSA-3304356", "R-HSA-6811555", "R-MMU-1660499", "R-MMU-8943724", "R-HSA-917729", "R-HSA-201722", "R-HSA-5693571", "R-RNO-6807004", "R-HSA-9909649", "R-RNO-3214847", "R-HSA-9754189", "R-RNO-1660499", "R-DME-3214847", "R-HSA-9818564", "R-MMU-6807004", "R-BTA-6807505", "R-BTA-917729", "R-HSA-8939236", "R-HSA-8875360", "R-HSA-73779", "R-DME-9013420", "R-BTA-983168", "R-MMU-182971", "R-MMU-201722", "R-DDI-9646399", "R-MMU-69541", "R-CEL-416482", "R-DRE-6807505", "R-BTA-9772755", "R-HSA-9635644", "R-MMU-4655427", "R-MMU-1660514", "R-DME-6804758", "R-SCE-3899300", "R-DRE-3214847", "R-MMU-73779", "R-HSA-5655302", "R-HSA-4551638", "R-HSA-9018519", "R-DME-9909649", "R-RNO-3899300", "R-HSA-2173789", "R-CEL-264642", "R-MMU-76042", "R-DME-6804759", "R-MMU-8936459", "R-DRE-3214842", "R-CEL-114608", "R-HSA-3214815", "R-RNO-9933937", "R-MMU-674695", "R-DRE-5250924", 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presentation", "R-GGA-177504:r:Retrograde neurotrophin signalling", "R-BTA-8964038:r:LDL clearance", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-XTR-8964038:r:LDL clearance", "R-SSC-204005:r:COPII-mediated vesicle transport", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis"], "type": "Homologous_superfamily"}, "IPR011013": {"description": "Galactose mutarotase-like domain superfamily", "go_ids": ["GO:0005975", "GO:0030246"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0030246:carbohydrate binding:F"], "name": "Gal_mutarotase_sf_dom", "pathway_ids": ["R-MMU-70221", "R-HSA-6798695", "R-HSA-189085", "R-MMU-8853383", "R-SPO-6798695", "R-HSA-9683686", "R-HSA-6811438", "R-HSA-975578", "R-HSA-9694548", "R-BTA-6798695", "R-DDI-8853383", "R-HSA-9931929", "R-SPO-70221", "R-HSA-5659898", "R-BTA-70370", "R-SPO-8853383", "R-RNO-189085", "R-HSA-901042", "R-MMU-189085", "R-SSC-189085", "R-BTA-70221", "R-DDI-6798695", "R-HSA-532668", "R-BTA-8853383", "R-HSA-70221", "R-HSA-5357609", "R-SCE-70370", "R-SPO-70370", "R-SSC-70370", "R-MMU-70370", "R-RNO-8853383", "R-RNO-70221", "R-DME-975578", "R-SPO-189085", "R-HSA-8853383", "R-MMU-6798695", "R-RNO-975578", "R-HSA-70370", "R-RNO-70370", "R-MMU-975578", "R-HSA-9768727", "R-MMU-9768727", "R-RNO-6798695", "R-SCE-8853383"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-6811438:r:Intra-Golgi traffic", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-9694548:r:Maturation of spike protein", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-9931929:r:Defective GALM causes GALAC4", "R-SPO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-5659898:r:Intestinal saccharidase deficiencies", "R-BTA-70370:r:Galactose catabolism", "R-SPO-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-SSC-189085:r:Digestion of dietary carbohydrate", "R-BTA-70221:r:Glycogen breakdown (glycogenolysis)", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-BTA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-5357609:r:Glycogen storage disease type II (GAA)", "R-SCE-70370:r:Galactose catabolism", "R-SPO-70370:r:Galactose catabolism", "R-SSC-70370:r:Galactose catabolism", "R-MMU-70370:r:Galactose catabolism", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-SPO-189085:r:Digestion of dietary carbohydrate", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-70370:r:Galactose catabolism", "R-RNO-70370:r:Galactose catabolism", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-6798695:r:Neutrophil degranulation", "R-SCE-8853383:r:Lysosomal oligosaccharide catabolism"], "type": "Homologous_superfamily"}, "IPR011014": {"description": "Mechanosensitive ion channel MscS, transmembrane-2", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "MscS_channel_TM-2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011015": {"description": "LEM/LEM-like domain superfamily", "go_ids": [], "go_terms": [], "name": "LEM/LEM-like_dom_sf", "pathway_ids": ["R-HSA-9013405", "R-HSA-9013409", "R-RNO-2995383", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-9013106", "R-MMU-9013404", "R-HSA-9668328", "R-RNO-9609523", "R-HSA-9013423", "R-MMU-2980766", "R-HSA-9035034", "R-HSA-9013148", "R-RNO-9013404", "R-MMU-9609523", "R-HSA-9013408", "R-HSA-9609523", "R-RNO-9013408", "R-RNO-2980766", "R-MMU-2995383", "R-HSA-9696270", "R-HSA-2995383", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-4419969", "R-HSA-2980766", "R-MMU-4419969", "R-RNO-4419969", "R-MMU-9013149", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-2980766:r:Nuclear Envelope Breakdown", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR011016": {"description": "Zinc finger, RING-CH-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_RING-CH", "pathway_ids": ["PWY-7511", "R-SCE-9954709", "R-HSA-983168", "R-SCE-983168", "R-HSA-901032", "R-HSA-9954709", "R-MMU-983168", "R-MMU-9954709"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR011017": {"description": "TRASH domain", "go_ids": [], "go_terms": [], "name": "TRASH_dom", "pathway_ids": ["R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-BTA-975957", "R-MMU-72689", "R-HSA-9010553", "R-HSA-156827", "R-DRE-9954709", "R-RNO-72689", "R-RNO-1799339", "R-MMU-9954709", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-BTA-72706", "R-RNO-9954716", "R-HSA-9954709", "R-DME-1799339", "R-HSA-5655302", "R-MMU-975956", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-DRE-156827", "R-DRE-975956", "R-RNO-156827", "R-BTA-9954716", "R-MMU-9954714", "R-BTA-6791226", "R-DRE-9954714", "R-DME-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72706", "R-HSA-72689", "R-DRE-975957", "R-HSA-9764725", "R-HSA-72764", "R-MMU-9764725", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-RNO-6791226", "R-HSA-9703465", "R-MMU-1799339", "R-DRE-1799339", "R-HSA-975957", "R-DME-9954714", "R-HSA-6791226", "R-RNO-975956", "R-BTA-975956", "R-DRE-72689", "R-RNO-9954709", "R-BTA-9954709", "R-DRE-9954716", "R-DRE-6791226", "R-HSA-9954714", "R-DME-975957", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012", "R-HSA-1839117"], "pathways": ["R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-192823:r:Viral mRNA Translation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR011019": {"description": "KIND domain", "go_ids": [], "go_terms": [], "name": "KIND_dom", "pathway_ids": ["R-HSA-9008059", "R-MMU-1660499", "R-HSA-9696270", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-1660499", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR011020": {"description": "HTTM-like", "go_ids": [], "go_terms": [], "name": "HTTM-like", "pathway_ids": ["PWY-7999", "R-HSA-159740", "R-HSA-9673240", "R-MMU-159740", "R-RNO-159740", "R-BTA-159740"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-9673240:r:Defective gamma-carboxylation of F9", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-BTA-159740:r:Gamma-carboxylation of protein precursors"], "type": "Domain"}, "IPR011021": {"description": "Arrestin-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Arrestin-like_N", "pathway_ids": ["R-MMU-8856828", "R-HSA-5674135", "R-BTA-5689880", "R-HSA-6802952", "R-HSA-5689880", "R-HSA-8856828", "R-CEL-5099900", "R-SSC-844456", "R-MMU-5099900", "R-HSA-2485179", "R-CEL-432722", "R-BTA-2514859", "R-MMU-5689880", "R-MMU-456926", "R-HSA-9649948", "R-HSA-9707564", "R-HSA-6802955", "R-RNO-432722", "R-DME-5674135", "R-HSA-6802948", "R-MMU-5635838", "R-HSA-2514859", "R-RNO-432720", "R-HSA-456926", "R-HSA-432720", "R-HSA-9660826", "R-HSA-418555", "R-CEL-5674135", "R-RNO-844456", "R-CEL-456926", "R-RNO-5689880", "R-RNO-456926", "R-HSA-5635838", "R-BTA-418555", "R-CEL-8856825", "R-RNO-2514859", "R-HSA-844456", "R-HSA-9656223", "R-RNO-418555", "R-DME-432720", "R-DME-418555", "R-MMU-5674135", "R-HSA-2122948", "R-MMU-8856825", "R-CEL-432720", "R-MMU-432722", "R-CEL-844456", "R-BTA-5674135", "R-HSA-9839389", "R-BTA-9839389", "R-HSA-6802946", "R-MMU-2514859", "R-DME-8856828", "R-RNO-8856828", "R-RNO-5674135", "R-RNO-9839389", "R-RNO-5099900", "R-HSA-432722", "R-MMU-432720", "R-HSA-9617629", "R-BTA-8856828", "R-DME-8856825", "R-CEL-8856828", "R-BTA-5635838", "R-RNO-8856825", "R-MMU-9839389", "R-BTA-432720", "R-BTA-456926", "R-HSA-5099900", "R-DME-432722", "R-MMU-844456", "R-BTA-8856825", "R-HSA-8856825", "R-DME-9839389", "R-BTA-432722", "R-MMU-418555", "R-DME-5689880"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-SSC-844456:r:The NLRP3 inflammasome", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-5635838:r:Activation of SMO", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-418555:r:G alpha (s) signalling events", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-RNO-844456:r:The 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"R-MMU-111465", "R-MMU-205043", "R-MMU-202424", "R-MMU-8983711", "R-HSA-975871", "R-DME-214411", "R-DME-5357905", "R-MMU-1169091", "R-RNO-5660668", "R-DRE-844456", "R-MMU-5607761", "R-MMU-447043", "R-SSC-937041", "R-MMU-75153", "R-HSA-5603037", "R-RNO-69416", "R-DME-445989", "R-HSA-9909649", "R-MMU-72187", "R-MMU-9948001", "R-DME-6803207", "R-MMU-264870", "R-HSA-9948011", "R-BTA-1257604", "R-HSA-111465", "R-MMU-2562578", "R-HSA-140534", "R-DME-214399", "R-MMU-373752", "R-CFA-5357905", "R-HSA-844615", "R-CEL-9020702", "R-HSA-202733", "R-BTA-2562578", "R-HSA-1989781", "R-GGA-433822", "R-HSA-1606341", "R-BTA-9948011", "R-MMU-5607764", "R-MMU-844455", "R-HSA-1834941", "R-BTA-9960525", "R-CEL-9948011", "R-HSA-9818749", "R-HSA-75893", "R-HSA-5676590", "R-HSA-9013424", "R-RNO-448706", "R-HSA-9686347", "R-BTA-140534", "R-HSA-72187", "R-BTA-9960519", "R-MMU-9833482", "R-BTA-5620971", "R-RNO-202424", "R-HSA-9707564", "R-MMU-975163", "R-MMU-193634", "R-HSA-6783783", "R-DRE-5689901", "R-MMU-75893", "R-MMU-5684264", "R-MMU-140534", "R-BTA-937042", "R-HSA-193670", "R-HSA-975144", "R-RNO-209560", "R-CFA-5357786", "R-MMU-73856", "R-HSA-111458", "R-HSA-75158", "R-SSC-5676594", "R-HSA-1169091", "R-MMU-2871837", "R-HSA-3134975", "R-RNO-445989", "R-HSA-8948751", "R-HSA-5603041", "R-HSA-9860927", "R-HSA-193692", "R-MMU-75158", "R-HSA-9968551", "R-HSA-445989", "R-HSA-8853884", "R-HSA-5689901", "R-MMU-205017", "R-HSA-205017", "R-MMU-5676594", "R-HSA-111469", "R-HSA-975138", "R-MMU-9960525", "R-GGA-573298", "R-HSA-3769402", "R-HSA-9960525", "R-HSA-209543", "R-HSA-418889", "R-HSA-418886", "R-RNO-75157", "R-HSA-936440", "R-HSA-2559582", "R-HSA-1169408", "R-MMU-205025", "R-HSA-9909505", "R-HSA-198323", "R-DRE-5218900", "R-DRE-159236", "R-MMU-5213460", "R-HSA-448706", "R-HSA-3214841", "R-MMU-9960519", "R-SSC-5689880", "R-XTR-9020702", "R-RNO-373752", "R-HSA-9833110", "R-HSA-9920951", "R-BTA-168638", "R-HSA-937072", "R-HSA-5607764", "R-HSA-193648", "R-SSC-5668541", "R-MMU-5357786", "R-HSA-9013420", "R-BTA-5689896", "R-HSA-8948747", "R-DRE-111459", "R-RNO-5684264", "R-HSA-6807878", "R-HSA-111464", "R-DRE-3371378", "R-HSA-9679191", "R-MMU-844456", "R-MMU-209563", "R-RNO-112409", "R-HSA-5213460", "R-HSA-1810476", "R-HSA-5668541", "R-RNO-5218900", "R-BTA-450302", "R-GGA-977240", "R-RNO-5357956", "R-RNO-264870", "R-MMU-936440", "R-RNO-5675482", "R-MMU-9758274", "R-MMU-9696270", "R-BTA-975163", "R-RNO-5669034", "R-RNO-168928", "R-MMU-3295583", "R-HSA-9696273", "R-HSA-975163"], "pathways": ["R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9968551:r:Regulation of GBP-mediated host defense", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-9948001:r:CASP4 inflammasome assembly", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-112409:r:RAF-independent MAPK1/3 activation", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-111458:r:Formation of apoptosome", "R-HSA-373752:r:Netrin-1 signaling", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-69416:r:Dimerization of procaspase-8", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-MMU-448706:r:Interleukin-1 processing", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-DRE-9953170:r:GBP-mediated host defense", "R-DRE-9948001:r:CASP4 inflammasome assembly", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-3371378:r:Regulation by c-FLIP", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DRE-75893:r:TNF signaling", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-5620971:r:Pyroptosis", "R-RNO-844455:r:The NLRP1 inflammasome", "R-DRE-9960519:r:CASP4-mediated substrate cleavage", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-RNO-75153:r:Apoptotic execution phase", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-69416:r:Dimerization of procaspase-8", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-RNO-205017:r:NFG and proNGF binds to p75NTR", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-RNO-3371378:r:Regulation by c-FLIP", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-DRE-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-8983711:r:OAS antiviral response", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-5218900:r:CASP8 activity is inhibited", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-SSC-3371378:r:Regulation by c-FLIP", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-BTA-844456:r:The NLRP3 inflammasome", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-193681:r:Ceramide signalling", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-BTA-75893:r:TNF signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-205025:r:NADE modulates death signalling", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-DME-9020702:r:Interleukin-1 signaling", "R-SSC-75157:r:FasL/ CD95L signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-69416:r:Dimerization of procaspase-8", "R-RNO-9020702:r:Interleukin-1 signaling", "R-DRE-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-SSC-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-5689901:r:Metalloprotease DUBs", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-RNO-75158:r:TRAIL signaling", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-SSC-69416:r:Dimerization of procaspase-8", "R-RNO-111458:r:Formation of apoptosome", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DRE-9948011:r:CASP5 inflammasome assembly", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-RNO-844456:r:The NLRP3 inflammasome", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-3371378:r:Regulation by c-FLIP", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-HSA-3371378:r:Regulation by c-FLIP", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-HSA-844456:r:The NLRP3 inflammasome", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DRE-844455:r:The NLRP1 inflammasome", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-XTR-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-75157:r:FasL/ CD95L signaling", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-CFA-5689880:r:Ub-specific processing proteases", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-75893:r:TNF signaling", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-GGA-451477:r:MyD88-dependent cascade initiated on endosome membrane", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-75153:r:Apoptotic execution phase", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-BTA-5669034:r:TNFs bind their physiological receptors", "R-BTA-5218900:r:CASP8 activity is inhibited", "R-BTA-75157:r:FasL/ CD95L signaling", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-75157:r:FasL/ CD95L signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-5620971:r:Pyroptosis", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DRE-69416:r:Dimerization of procaspase-8", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-SSC-5218900:r:CASP8 activity is inhibited", "R-HSA-844623:r:The IPAF inflammasome", "R-HSA-3295583:r:TRP channels", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-9020702:r:Interleukin-1 signaling", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-111458:r:Formation of apoptosome", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5689901:r:Metalloprotease DUBs", "R-HSA-9960519:r:CASP4-mediated substrate cleavage", "R-MMU-3134963:r:DEx/H-box helicases activate type I 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"R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-CEL-373752:r:Netrin-1 signaling", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-8983711:r:OAS antiviral response", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-5660668:r:CLEC7A/inflammasome pathway", "R-DRE-844456:r:The NLRP3 inflammasome", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-447043:r:Neurofascin interactions", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", 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RIPK1-mediated regulated necrosis", "R-BTA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-72187:r:mRNA 3'-end processing", "R-BTA-9960519:r:CASP4-mediated substrate cleavage", "R-MMU-9833482:r:PKR-mediated signaling", "R-BTA-5620971:r:Pyroptosis", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-6783783:r:Interleukin-10 signaling", "R-DRE-5689901:r:Metalloprotease DUBs", "R-MMU-75893:r:TNF signaling", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-BTA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-193670:r:p75NTR negatively regulates cell cycle via SC1", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-CFA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-75158:r:TRAIL signaling", "R-SSC-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-MMU-75158:r:TRAIL signaling", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-5689901:r:Metalloprotease DUBs", "R-MMU-205017:r:NFG and proNGF binds to p75NTR", "R-HSA-205017:r:NFG and proNGF binds to p75NTR", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-GGA-573298:r:NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-RNO-75157:r:FasL/ CD95L signaling", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-205025:r:NADE modulates death signalling", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-5218900:r:CASP8 activity is inhibited", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-448706:r:Interleukin-1 processing", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-SSC-5689880:r:Ub-specific processing proteases", "R-XTR-9020702:r:Interleukin-1 signaling", "R-RNO-373752:r:Netrin-1 signaling", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-9013420:r:RHOU GTPase cycle", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8948747:r:Regulation of PTEN localization", "R-DRE-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-DRE-3371378:r:Regulation by c-FLIP", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-844456:r:The NLRP3 inflammasome", "R-MMU-209563:r:Axonal growth stimulation", "R-RNO-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5218900:r:CASP8 activity is inhibited", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-GGA-977240:r:MyD88 cascade initiated on plasma membrane", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-9696270:r:RND2 GTPase cycle", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-5669034:r:TNFs bind their physiological receptors", "R-RNO-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-3295583:r:TRP channels", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Homologous_superfamily"}, "IPR011030": {"description": 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Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-SSC-8963888:r:Chylomicron assembly", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-MMU-8964041:r:LDL remodeling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-GGA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DRE-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-RNO-8964041:r:LDL remodeling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-8866423:r:VLDL assembly", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-8964038:r:LDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-DME-8964041:r:LDL remodeling", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-SSC-8964041:r:LDL remodeling", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly"], "type": "Homologous_superfamily"}, "IPR011032": {"description": "GroES-like superfamily", "go_ids": [], "go_terms": [], "name": "GroES-like_sf", "pathway_ids": ["R-GGA-5365859", "R-HSA-6798695", "R-HSA-2142700", "R-HSA-2142691", "R-DDI-71384", "R-DDI-75105", "R-SCE-77346", "R-CEL-5365859", "R-MMU-2161541", "R-DRE-77346", "R-MMU-9013408", "R-HSA-9918487", "R-MTU-9635470", "R-MMU-199220", "R-SCE-71384", "R-HSA-77346", "R-CEL-71384", "R-SPO-5661270", "R-CEL-2161541", "R-MMU-77346", "R-SCE-5652227", "R-DME-71384", "R-DRE-6798695", "R-DDI-199220", "R-RNO-9013408", "R-HSA-9013408", "R-CEL-77346", "R-MMU-5652227", "R-DME-77346", "R-SPO-5365859", "R-SCE-5365859", "R-SPO-5652227", "R-DDI-5365859", "R-RNO-5365859", "R-BTA-5652227", "R-SCE-5661270", "R-HSA-5365859", "R-RNO-71384", "R-DDI-77346", "R-HSA-71384", "R-SPO-71384", "R-MMU-5365859", "R-BTA-5661270", "R-HSA-75105", "R-MMU-6798695", "R-HSA-5652227", "R-RNO-6798695", "R-XTR-77346", "R-GGA-71384", "R-HSA-9029558", "R-RNO-5661270", "R-RNO-77346", "R-RNO-2161541", "R-DME-2161541", "R-DDI-2161541", "R-RNO-75105", "R-HSA-2161541", "R-DME-5365859", "R-HSA-199220", "R-HSA-6803205", "R-RNO-199220", "R-HSA-5661270", "R-BTA-71384", "R-MMU-5661270", "R-SPO-77346", "R-HSA-9918481", "R-HSA-163765", "R-HSA-2162123", "R-GGA-2161541", "R-SPO-2161541", "R-RNO-5652227", "R-HSA-9841251", "R-MMU-75105", "R-BTA-9013408", "R-HSA-2426168", "R-SCE-2161541", "R-MMU-71384"], "pathways": ["R-GGA-5365859:r:RA biosynthesis pathway", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DDI-71384:r:Ethanol oxidation", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-5365859:r:RA biosynthesis pathway", "R-MMU-2161541:r:Abacavir metabolism", "R-DRE-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SCE-71384:r:Ethanol oxidation", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-71384:r:Ethanol oxidation", "R-SPO-5661270:r:Formation of xylulose-5-phosphate", "R-CEL-2161541:r:Abacavir metabolism", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SCE-5652227:r:Fructose biosynthesis", "R-DME-71384:r:Ethanol oxidation", "R-DRE-6798695:r:Neutrophil degranulation", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-5652227:r:Fructose biosynthesis", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SPO-5365859:r:RA biosynthesis pathway", "R-SCE-5365859:r:RA biosynthesis pathway", "R-SPO-5652227:r:Fructose biosynthesis", "R-DDI-5365859:r:RA biosynthesis pathway", "R-RNO-5365859:r:RA biosynthesis pathway", "R-BTA-5652227:r:Fructose biosynthesis", "R-SCE-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-5365859:r:RA biosynthesis pathway", "R-RNO-71384:r:Ethanol oxidation", "R-DDI-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-71384:r:Ethanol oxidation", "R-SPO-71384:r:Ethanol oxidation", "R-MMU-5365859:r:RA biosynthesis pathway", "R-BTA-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5652227:r:Fructose biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-XTR-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-GGA-71384:r:Ethanol oxidation", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-2161541:r:Abacavir metabolism", "R-DME-2161541:r:Abacavir metabolism", "R-DDI-2161541:r:Abacavir metabolism", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-2161541:r:Abacavir metabolism", "R-DME-5365859:r:RA biosynthesis pathway", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-BTA-71384:r:Ethanol oxidation", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-SPO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-GGA-2161541:r:Abacavir metabolism", "R-SPO-2161541:r:Abacavir metabolism", "R-RNO-5652227:r:Fructose biosynthesis", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SCE-2161541:r:Abacavir metabolism", "R-MMU-71384:r:Ethanol oxidation"], "type": "Homologous_superfamily"}, "IPR011033": {"description": "PRC-barrel-like superfamily", "go_ids": [], "go_terms": [], "name": "PRC_barrel-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011034": {"description": "Formyl transferase-like, C-terminal domain superfamily", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Formyl_transferase-like_C_sf", "pathway_ids": ["R-HSA-110331", "R-HSA-110357", "R-HSA-5368286", "R-MMU-196757", "R-RNO-110331", "R-RNO-196757", "R-XTR-196757", "R-HSA-110330", "R-RNO-110357", "R-MMU-110357", "R-HSA-196757", "R-MMU-110331"], "pathways": ["R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-196757:r:Metabolism of folate and pterines", "R-RNO-110331:r:Cleavage of the damaged purine", "R-RNO-196757:r:Metabolism of folate and pterines", "R-XTR-196757:r:Metabolism of folate and pterines", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-196757:r:Metabolism of folate and pterines", "R-MMU-110331:r:Cleavage of the damaged purine"], "type": "Homologous_superfamily"}, "IPR011035": {"description": "Large ribosomal subunit protein bL25/Gln-tRNA synthetase, anti-codon-binding domain superfamily", "go_ids": ["GO:0006412"], "go_terms": ["GO:0006412:translation:P"], "name": "Ribosomal_bL25/Gln-tRNA_synth", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-HSA-6782315", "R-RNO-9856649", "R-DME-9856649", "R-HSA-9856649", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR011037": {"description": "Pyruvate kinase-like, insert domain superfamily", "go_ids": [], "go_terms": [], "name": "Pyrv_Knase-like_insert_dom_sf", "pathway_ids": ["PWY-1042", "PWY-7383", "PWY-8404", "PWY-2221", "PWY-6886", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-HSA-6798695", "R-CFA-70171", "R-MMU-70171", "R-SPO-6798695", "R-HSA-211945", "R-SPO-70268", "R-MMU-9861718", "R-SCE-6798695", "R-BTA-211945", "R-CEL-947581", "R-HSA-9861718", "R-MMU-211945", "R-HSA-947581", "R-DME-947581", "R-RNO-70171", "R-GGA-352882", "R-RNO-70268", "R-CFA-70268", "R-HSA-70171", "R-HSA-163765", "R-MMU-70268", "R-DDI-6798695", "R-DDI-9861718", "R-SCE-70171", "R-DME-6798695", "R-MMU-947581", "R-DME-70171", "R-HSA-210745", "R-HSA-9764725", "R-DDI-70171", "R-DME-9861718", "R-HSA-70268", "R-DME-70268", "R-RNO-211945", "R-DRE-947581", "R-BTA-947581", "R-DDI-70268", "R-DRE-211945", "R-MMU-6798695", "R-HSA-9692914", "R-SPO-70171", "R-SCE-70268"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-HSA-6798695:r:Neutrophil degranulation", "R-CFA-70171:r:Glycolysis", "R-MMU-70171:r:Glycolysis", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-SPO-70268:r:Pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-211945:r:Phase I - Functionalization of compounds", "R-CEL-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-RNO-70268:r:Pyruvate metabolism", "R-CFA-70268:r:Pyruvate metabolism", "R-HSA-70171:r:Glycolysis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-MMU-70268:r:Pyruvate metabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-SCE-70171:r:Glycolysis", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-947581:r:Molybdenum cofactor biosynthesis", "R-DME-70171:r:Glycolysis", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DDI-70171:r:Glycolysis", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-DME-70268:r:Pyruvate metabolism", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-DRE-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-70268:r:Pyruvate metabolism", "R-DRE-211945:r:Phase I - Functionalization of compounds", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-SPO-70171:r:Glycolysis", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Homologous_superfamily"}, "IPR011039": {"description": "Transcription Factor IIF, Rap30/Rap74, interaction", "go_ids": ["GO:0006367"], "go_terms": ["GO:0006367:transcription initiation at RNA polymerase II promoter:P"], "name": "TFIIF_interaction", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-CEL-72165", "R-MMU-9770562", "R-RNO-73779", "R-CEL-72203", "R-DDI-73776", "R-DME-72163", "R-RNO-72163", "R-DME-75955", "R-DDI-72163", "R-HSA-167158", "R-RNO-9018519", "R-MMU-75955", "R-RNO-73776", "R-MMU-112382", "R-BTA-9018519", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DME-72086", "R-DME-72203", "R-BTA-77075", "R-DDI-674695", "R-CEL-9770562", "R-CEL-75953", "R-SPO-6796648", "R-DME-75953", "R-CEL-73776", "R-BTA-72163", "R-BTA-75955", "R-BTA-75953", "R-SPO-9018519", "R-MMU-72163", "R-HSA-6803529", "R-HSA-167242", "R-HSA-8851708", "R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-CEL-112382", "R-HSA-167160", "R-DDI-77075", "R-SPO-73779", "R-DDI-113418", "R-MMU-72086", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DME-77075", "R-DME-73779", "R-DME-9770562", "R-DME-73776", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-72165", "R-MMU-73776", "R-DDI-76042", "R-CEL-72163", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-DME-113418", "R-RNO-113418", "R-HSA-72203", "R-MMU-6796648", "R-CEL-75955", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-RNO-6796648", "R-RNO-75955", "R-BTA-674695", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-167290", "R-RNO-77075", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-CEL-9018519", "R-RNO-9770562", "R-HSA-76042", "R-HSA-674695", "R-BTA-6807505", "R-SPO-72163", "R-BTA-72203", "R-HSA-112382", "R-HSA-73779", "R-RNO-6807505", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-RNO-674695", "R-DME-76042", "R-MMU-113418", "R-BTA-76042", "R-SPO-6807505", "R-HSA-6796648", "R-HSA-167287", "R-HSA-167246", "R-RNO-72165", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-HSA-9018519", "R-MMU-76042", "R-SPO-75953", "R-SPO-113418", "R-CEL-6807505", "R-DME-674695", "R-RNO-72203", "R-RNO-76042", "R-DME-9018519", "R-BTA-72086", "R-DDI-73779", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-CEL-113418", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-MMU-9018519", "R-DDI-6807505", "R-DME-6807505", "R-SPO-9770562", "R-HSA-167200", "R-DME-72165", "R-RNO-112382", "R-SCE-674695", "R-BTA-9770562", "R-CEL-6796648", "R-RNO-75953", "R-MMU-6803529", "R-BTA-113418", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-HSA-167152", "R-HSA-113418", "R-BTA-112382", "R-HSA-9918481", "R-RNO-6803529", "R-BTA-6796648", "R-SPO-72203", "R-SCE-72203", "R-SCE-6796648", "R-RNO-72086", "R-SPO-77075", "R-SCE-113418", "R-SCE-72086", "R-CEL-77075", "R-SCE-77075", "R-DDI-75953", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA 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"R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72086:r:mRNA Capping", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 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"R-MMU-6796648", "R-RNO-204174", "R-MMU-6783984", "R-SPO-75105", "R-BTA-9861559", "R-HSA-9865125", "R-SCE-6783984", "R-HSA-3371599", "R-MMU-75105", "R-HSA-9857492", "R-HSA-70268", "R-RNO-70895", "R-RNO-6783984", "R-SPO-196780", "R-CEL-70268", "R-DDI-9853506", "R-CEL-70263", "R-SCE-9861559", "R-HSA-200425", "R-HSA-6783984", "R-SCE-70263", "R-MMU-5362517", "R-HSA-9865113", "R-DDI-9861559", "R-HSA-2426168", "R-SPO-204174", "R-RNO-70263"], "pathways": ["R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-BTA-5362517:r:Signaling by Retinoic Acid", "R-RNO-9857492:r:Protein lipoylation", "R-MMU-70263:r:Gluconeogenesis", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-70263:r:Gluconeogenesis", 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"R-HSA-9907570:r:Loss-of-function mutations in DLD cause MSUD3/DLDD", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-GGA-9857492:r:Protein lipoylation", "R-BTA-196780:r:Biotin transport and metabolism", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-RNO-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-BTA-70268:r:Pyruvate metabolism", "R-SPO-9857492:r:Protein lipoylation", "R-CEL-9857492:r:Protein lipoylation", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-70263:r:Gluconeogenesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9909438:r:3-Methylcrotonyl-CoA carboxylase deficiency", "R-SCE-196780:r:Biotin transport and metabolism", "R-MMU-9858328:r:OADH complex 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"R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-6783984:r:Glycine degradation", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-9865125:r:Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD", "R-SCE-6783984:r:Glycine degradation", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9857492:r:Protein lipoylation", "R-HSA-70268:r:Pyruvate metabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-RNO-6783984:r:Glycine degradation", "R-SPO-196780:r:Biotin transport and metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-CEL-70263:r:Gluconeogenesis", "R-SCE-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-200425:r:Carnitine shuttle", "R-HSA-6783984:r:Glycine degradation", "R-SCE-70263:r:Gluconeogenesis", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-DDI-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR011054": {"description": "Rudiment single hybrid motif", "go_ids": [], "go_terms": [], "name": "Rudment_hybrid_motif", "pathway_ids": ["R-SPO-73817", "R-CEL-71032", "R-DDI-75105", "R-SPO-70268", "R-DDI-70895", "R-HSA-196780", "R-SCE-73817", "R-MMU-73817", "R-MMU-70263", "R-RNO-75105", "R-DDI-200425", "R-RNO-196780", "R-HSA-70263", "R-RNO-70268", "R-DDI-73817", "R-DDI-196780", "R-MMU-70895", "R-SPO-200425", "R-RNO-200425", "R-SPO-70263", "R-HSA-71032", "R-RNO-71032", "R-MMU-71032", "R-SCE-200425", "R-SCE-75105", "R-SCE-70268", "R-HSA-163765", "R-CEL-196780", "R-MMU-70268", "R-MMU-200425", "R-SPO-75105", "R-BTA-196780", "R-HSA-70895", "R-HSA-3371599", "R-MMU-75105", "R-MMU-196780", "R-HSA-70268", "R-BTA-70268", "R-GGA-419140", "R-RNO-70895", "R-SPO-196780", "R-CEL-70268", "R-CEL-70263", "R-HSA-200425", "R-DME-73817", "R-BTA-70263", "R-HSA-75105", "R-SCE-70263", "R-HSA-9909438", "R-BTA-73817", "R-SCE-196780", "R-HSA-73817", "R-HSA-2426168", "R-RNO-70263"], "pathways": ["R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-SPO-70268:r:Pyruvate metabolism", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-196780:r:Biotin transport and metabolism", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-70263:r:Gluconeogenesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-200425:r:Carnitine shuttle", "R-RNO-196780:r:Biotin transport and metabolism", "R-HSA-70263:r:Gluconeogenesis", "R-RNO-70268:r:Pyruvate metabolism", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-196780:r:Biotin transport and metabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-SPO-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-SPO-70263:r:Gluconeogenesis", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-RNO-71032:r:Propionyl-CoA catabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-SCE-200425:r:Carnitine shuttle", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-70268:r:Pyruvate metabolism", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-CEL-196780:r:Biotin transport and metabolism", "R-MMU-70268:r:Pyruvate metabolism", "R-MMU-200425:r:Carnitine shuttle", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-196780:r:Biotin transport and metabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-GGA-419140:r:De novo synthesis of IMP", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-CEL-70263:r:Gluconeogenesis", "R-HSA-200425:r:Carnitine shuttle", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-70263:r:Gluconeogenesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-70263:r:Gluconeogenesis", "R-HSA-9909438:r:3-Methylcrotonyl-CoA carboxylase deficiency", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-196780:r:Biotin transport and metabolism", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR011055": {"description": "Duplicated hybrid 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biosynthesis", "R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-DME-500753:r:Pyrimidine biosynthesis", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-SPO-71336:r:Pentose phosphate pathway", "R-SCE-71336:r:Pentose phosphate pathway"], "type": "Homologous_superfamily"}, "IPR011061": {"description": "Hirudin/antistatin", "go_ids": ["GO:0004857"], "go_terms": ["GO:0004857:enzyme inhibitor activity:F"], "name": "Hirudin/antistatin", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011063": {"description": "tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal", "go_ids": [], "go_terms": [], "name": "TilS/TtcA_N", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR011064": {"description": "Allophycocyanin linker chain", "go_ids": ["GO:0015979", "GO:0030089"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0030089:phycobilisome:C"], "name": "Allophyco_linker_chain", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011065": {"description": "Kunitz inhibitor STI-like superfamily", "go_ids": [], "go_terms": [], "name": "Kunitz_inhibitor_STI-like_sf", "pathway_ids": ["R-HSA-5250989", "R-HSA-5250968", "R-HSA-5250971", "R-HSA-5250982", "R-HSA-5250992", "R-HSA-5250955", "R-HSA-5250981", "R-HSA-5250958"], "pathways": ["R-HSA-5250989:r:Toxicity of botulinum toxin type G (botG)", "R-HSA-5250968:r:Toxicity of botulinum toxin type A (botA)", "R-HSA-5250971:r:Toxicity of botulinum toxin type C (botC)", "R-HSA-5250982:r:Toxicity of tetanus toxin (tetX)", "R-HSA-5250992:r:Toxicity of botulinum toxin type E (botE)", "R-HSA-5250955:r:Toxicity of botulinum toxin type D (botD)", "R-HSA-5250981:r:Toxicity of botulinum toxin type F (botF)", "R-HSA-5250958:r:Toxicity of botulinum toxin type B (botB)"], "type": "Homologous_superfamily"}, "IPR011066": {"description": "Mechanosensitive ion channel MscS, C-terminal domain superfamily", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "MscS_channel_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011067": {"description": "Plasmid maintenance toxin/Cell growth inhibitor", "go_ids": [], "go_terms": [], "name": "Plasmid_toxin/cell-grow_inhib", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011068": {"description": "Nucleotidyltransferase, class I-like, C-terminal", "go_ids": ["GO:0003723", "GO:0016779", "GO:0031123"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0016779:nucleotidyltransferase activity:F", "GO:0031123:RNA 3'-end processing:P"], "name": "NuclTrfase_I-like_C", "pathway_ids": ["R-MMU-9930044", "R-HSA-9930044", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-77595", "R-BTA-73856", "R-HSA-73856", "R-MMU-73856", "R-DDI-9770562", "R-HSA-72187", "R-SPO-9930044", "R-HSA-77595", "R-SPO-9770562", "R-MMU-72187", "R-BTA-9770562", "R-HSA-9918481", "R-DDI-9930044", "R-BTA-77595"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-9930044:r:Nuclear RNA decay", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Homologous_superfamily"}, "IPR011070": {"description": "Globular protein, non-globular alpha/beta subunit", "go_ids": [], "go_terms": [], "name": "Globular_prot_asu/bsu", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-HSA-9865881", "R-MMU-611105", "R-DRE-9865881", "R-BTA-9865881", "R-RNO-9865881", "R-GGA-9865881", "R-CEL-9865881", "R-DME-9865881", "R-SSC-9865881", "R-BTA-611105", "R-MMU-9865881"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-9865881:r:Complex III assembly", "R-MMU-611105:r:Respiratory electron transport", "R-DRE-9865881:r:Complex III assembly", "R-BTA-9865881:r:Complex III assembly", "R-RNO-9865881:r:Complex III assembly", "R-GGA-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-9865881:r:Complex III assembly", "R-SSC-9865881:r:Complex III assembly", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR011071": {"description": "Polysaccharide lyase family 8-like, C-terminal", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "Lyase_8-like_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011072": {"description": "HR1 rho-binding domain", "go_ids": ["GO:0007165"], "go_terms": ["GO:0007165:signal transduction:P"], "name": "HR1_rho-bd", "pathway_ids": ["R-RNO-9013026", "R-SCE-399997", "R-HSA-6798695", "R-HSA-9013409", "R-SPO-2029485", "R-MMU-8856828", "R-HSA-9013422", "R-BTA-5625886", "R-RNO-9013422", "R-MMU-9013106", "R-HSA-8856828", "R-SCE-2029485", "R-SPO-389357", "R-RNO-416572", "R-RNO-9013149", "R-MMU-5625740", "R-SPO-202424", "R-MMU-4420097", "R-SPO-76005", "R-MMU-416572", "R-HSA-3928662", "R-RNO-111465", "R-HSA-4420097", "R-SPO-9013106", "R-DRE-9013406", "R-MMU-9013422", "R-SCE-5607764", "R-RNO-5625740", "R-SCE-8980692", "R-MMU-5627117", "R-SPO-5668599", "R-DRE-5666185", "R-RNO-9013406", "R-HSA-203641", "R-SCE-9856530", "R-SPO-9634635", "R-BTA-5625740", "R-DME-9013149", "R-DRE-9013106", "R-MMU-9013407", "R-SPO-5607764", "R-DME-8980692", "R-DME-5625886", "R-RNO-9013407", "R-HSA-416482", "R-SPO-5218920", "R-SCE-1489509", "R-HSA-9696264", "R-SPO-8980692", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013406", "R-RNO-9696264", "R-DRE-9013026", "R-BTA-8980692", "R-DRE-8980692", "R-HSA-9013026", "R-MMU-6798695", "R-MMU-9696264", "R-SCE-2871837", "R-SPO-2179392", "R-BTA-9013106", "R-RNO-4420097", "R-HSA-9013407", "R-RNO-6798695", "R-SPO-6798695", "R-HSA-416572", "R-SPO-1489509", "R-SCE-2179392", "R-MMU-9856530", "R-RNO-9696270", "R-MMU-8980692", "R-RNO-8980692", "R-SCE-6798695", "R-HSA-5625740", "R-HSA-9013106", "R-SPO-5218921", "R-MMU-203641", "R-DME-5625740", "R-SCE-76005", "R-HSA-5625886", "R-SPO-5625740", "R-SCE-1169091", "R-SPO-114516", "R-SCE-9634635", "R-RNO-5666185", "R-RNO-416482", "R-RNO-5625886", "R-HSA-9013148", "R-RNO-3928662", "R-DRE-9013149", "R-MMU-5625886", "R-CEL-9013406", "R-RNO-8856828", "R-RNO-9013106", "R-DRE-9856530", "R-SCE-4419969", "R-RNO-203641", "R-SPO-6804757", "R-MMU-111465", "R-SPO-1257604", "R-SPO-399997", "R-SPO-9856530", "R-RNO-5627117", "R-SCE-5625740", "R-MMU-5666185", "R-XTR-8856828", "R-CEL-8856828", "R-BTA-5666185", "R-SPO-114508", "R-HSA-9696270", "R-SCE-114516", "R-HSA-5666185", "R-SPO-4419969", "R-DRE-5625740", "R-SPO-1169091", "R-HSA-9679191", "R-SCE-9013106", "R-RNO-9856530", "R-HSA-3928663", "R-SPO-2871837", "R-SCE-5218921", "R-SCE-114508", "R-MMU-9013026", "R-MMU-3928662", "R-MMU-416482", "R-HSA-111465", "R-MMU-9696270", "R-HSA-9013406", "R-SCE-5668599", "R-HSA-9856530", "R-MMU-9013149", "R-SCE-202424", "R-DME-9856530", "R-HSA-5627117"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-SCE-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-SPO-202424:r:Downstream TCR signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-9013106:r:RHOC GTPase cycle", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-SCE-8980692:r:RHOA GTPase cycle", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-9013106:r:RHOC GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-1489509:r:DAG and IP3 signaling", "R-HSA-9696264:r:RND3 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-SCE-2871837:r:FCERI mediated NF-kB activation", "R-SPO-2179392:r:EGFR Transactivation by Gastrin", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013407:r:RHOH GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-SPO-1489509:r:DAG and IP3 signaling", "R-SCE-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-SCE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-SCE-1169091:r:Activation of NF-kappaB in B cells", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-SCE-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SPO-399997:r:Acetylcholine regulates insulin secretion", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-SPO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-SPO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-SPO-2871837:r:FCERI mediated NF-kB activation", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-SCE-114508:r:Effects of PIP2 hydrolysis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-SCE-202424:r:Downstream TCR signaling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Domain"}, "IPR011074": {"description": "CRAL/TRIO, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CRAL/TRIO_N_dom", "pathway_ids": ["R-HSA-9008059", "R-MMU-8877627", "R-HSA-9918438", "R-RNO-432720", "R-RNO-8877627", "R-HSA-8877627", "R-HSA-432720", "R-BTA-2187335", "R-MMU-2187335", "R-MMU-2453902", "R-BTA-2453902", "R-MMU-432720", "R-HSA-2187335", "R-GGA-2187335", "R-GGA-2453902", "R-HSA-2453902"], "pathways": ["R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-8877627:r:Vitamin E transport", "R-HSA-9918438:r:Defective visual phototransduction due to RDH5 loss of function", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-8877627:r:Vitamin E transport", "R-HSA-8877627:r:Vitamin E transport", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-MMU-2187335:r:The retinoid cycle in cones (daylight vision)", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-GGA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-GGA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Domain"}, "IPR011075": {"description": "Tetracyclin repressor-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011076": {"description": "Malate synthase superfamily", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Malate_synth_sf", "pathway_ids": ["PWY-7854", "PWY-7295", "PWY-7118", "PWY-7294"], "pathways": ["PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7295:t:L-arabinose degradation IV", "PWY-7118:t:chitin deacetylation", "PWY-7294:t:D-xylose degradation IV"], "type": "Homologous_superfamily"}, "IPR011078": {"description": "Pyridoxal phosphate homeostasis protein", "go_ids": ["GO:0030170"], "go_terms": ["GO:0030170:pyridoxal phosphate binding:F"], "name": "PyrdxlP_homeostasis", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011079": {"description": "Alanine racemase, C-terminal", "go_ids": [], "go_terms": [], "name": "Ala_racemase_C", "pathway_ids": ["PWY-7383", "PWY-8040", "PWY-8443", "PWY-8072"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-8443:t:cyclosporin A biosynthesis", "PWY-8072:t:alanine racemization"], "type": "Domain"}, "IPR011081": {"description": "Bacterial Ig-like domain", "go_ids": [], "go_terms": [], "name": "Big_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011082": {"description": "Exosome-associated factor Rrp47/DNA strand repair C1D", "go_ids": [], "go_terms": [], "name": "Exosome-assoc_fac/DNA_repair", "pathway_ids": ["R-MMU-9930044", "R-DRE-9930044", "R-MMU-6791226", "R-HSA-9930044", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-DRE-6791226", "R-SPO-9930044", "R-SPO-6791226", "R-BTA-9930044"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-DRE-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-9930044:r:Nuclear RNA decay", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9930044:r:Nuclear RNA decay"], "type": "Family"}, "IPR011083": {"description": "Phage tail collar domain", "go_ids": [], "go_terms": [], "name": "Phage_tail_collar_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011084": {"description": "DNA repair metallo-beta-lactamase", "go_ids": [], "go_terms": [], "name": "DRMBL", "pathway_ids": ["R-GGA-353248", "R-GGA-5693571", "R-MMU-6783310", "R-DRE-5693571", "R-HSA-5693571", "R-GGA-353303", "R-RNO-5693571", "R-MMU-5693571", "R-HSA-6783310", "R-RNO-6783310", "R-DRE-6783310"], "pathways": ["R-GGA-353248:r:DNA damage recognition in global genomic repair", "R-GGA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-353303:r:Nucleotide Excision Repair", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR011086": {"description": "Domain of unknown function DUF1521", "go_ids": [], "go_terms": [], "name": "DUF1521", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011087": {"description": "Domain of unknown function DUF1522", "go_ids": [], "go_terms": [], "name": "DUF1522", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011088": {"description": "Bacteriophage phiNM3, A0EWY4", "go_ids": [], "go_terms": [], "name": "Phage_phiNM3_A0EWY4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011089": {"description": "GmrSD restriction endonucleases, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GmrSD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011090": {"description": "Integrating conjugative element protein, PFL4709", "go_ids": [], "go_terms": [], "name": "Integr_conj_element_PFL4709", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011093": {"description": "Putative conjugal transfer nickase/helicase TraI, C-terminal", "go_ids": [], "go_terms": [], "name": "TraI_2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011094": {"description": "Uncharacterised protein family, LppY/LpqO", "go_ids": [], "go_terms": [], "name": "Uncharacterised_LppY/LpqO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011095": {"description": "D-alanine--D-alanine ligase, C-terminal", "go_ids": ["GO:0008716"], "go_terms": ["GO:0008716:D-alanine-D-alanine ligase activity:F"], "name": "Dala_Dala_lig_C", "pathway_ids": ["PWY-7953", "PWY-6387", "PWY-6386"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "type": "Domain"}, "IPR011096": {"description": "FTP domain", "go_ids": [], "go_terms": [], "name": "FTP_domain", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR011098": {"description": "G5 domain", "go_ids": [], "go_terms": [], "name": "G5_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011099": {"description": "Glycosyl hydrolase family 67, C-terminal", "go_ids": ["GO:0005576", "GO:0045493", "GO:0046559"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0045493:xylan catabolic process:P", "GO:0046559:alpha-glucuronidase activity:F"], "name": "Glyco_hydro_67_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011100": {"description": "Glycosyl hydrolase family 67, catalytic domain", "go_ids": ["GO:0005576", "GO:0045493", "GO:0046559"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0045493:xylan catabolic process:P", "GO:0046559:alpha-glucuronidase activity:F"], "name": "Glyco_hydro_67_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011101": {"description": "Protein of unknown function DUF5131", "go_ids": [], "go_terms": [], "name": "DUF5131", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011102": {"description": "Signal transduction histidine kinase, HWE region", "go_ids": ["GO:0004673"], "go_terms": ["GO:0004673:protein histidine kinase activity:F"], "name": "Sig_transdc_His_kinase_HWE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011104": {"description": "HPr kinase/phosphorylase, C-terminal", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004672", "GO:0005524", "GO:0006109"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004672:protein kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006109:regulation of carbohydrate metabolic process:P"], "name": "Hpr_kin/Pase_C", "pathway_ids": ["PWY-7039", "PWY-5107"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-5107:t:phytol salvage pathway"], "type": "Domain"}, "IPR011105": {"description": "Cell wall hydrolase, SleB", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Cell_wall_hydrolase_SleB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011106": {"description": "Seven cysteines, N-terminal", "go_ids": [], "go_terms": [], "name": "MANSC_N", "pathway_ids": ["R-MMU-8856828", "R-HSA-8852405", "R-MMU-8852405", "R-RNO-8856825", "R-MMU-6806942", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-RNO-8856828", "R-HSA-6806942"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8852405:r:Signaling by MST1", "R-MMU-8852405:r:Signaling by MST1", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-6806942:r:MET Receptor Activation"], "type": "Domain"}, "IPR011107": {"description": "Type 1 protein phosphatase inhibitor", "go_ids": ["GO:0004865"], "go_terms": ["GO:0004865:protein serine/threonine phosphatase inhibitor activity:F"], "name": "PPI_Ypi1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011108": {"description": "Zn-dependent metallo-hydrolase, RNA specificity domain", "go_ids": [], "go_terms": [], "name": "RMMBL", "pathway_ids": ["R-CEL-159231", "R-RNO-6807505", "R-HSA-6807505", "R-DME-77595", "R-MMU-9770562", "R-SPO-159231", "R-MMU-77595", "R-HSA-73856", "R-DME-159231", "R-DDI-9770562", "R-CEL-73856", "R-HSA-72187", "R-DRE-6807505", "R-CEL-77595", "R-HSA-77595", "R-DME-9770562", "R-CEL-9770562", "R-DME-73856", "R-HSA-9918481", "R-MMU-159231", "R-BTA-77595", "R-HSA-9770562", "R-SCE-77595", "R-MMU-73856", "R-BTA-73856", "R-SPO-77595", "R-MMU-6807505", "R-DDI-6807505", "R-HSA-159231", "R-DME-6807505", "R-SPO-9770562", "R-MMU-72187", "R-DDI-77595", "R-BTA-9770562", "R-BTA-159231"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript"], "type": "Domain"}, "IPR011109": {"description": "DNA-binding recombinase domain", "go_ids": ["GO:0003677", "GO:0000150"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0000150:DNA strand exchange activity:F"], "name": "DNA_bind_recombinase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011110": {"description": "Two component regulator propeller", "go_ids": [], "go_terms": [], "name": "Reg_prop", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011111": {"description": "RepB plasmid partition", "go_ids": [], "go_terms": [], "name": "Plasmid_RepB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011112": {"description": "Rho termination factor-like, N-terminal", "go_ids": ["GO:0006353"], "go_terms": ["GO:0006353:DNA-templated transcription termination:P"], "name": "Rho-like_N", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR011113": {"description": "Rho termination factor, RNA-binding domain", "go_ids": ["GO:0003723", "GO:0006353"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006353:DNA-templated transcription termination:P"], "name": "Rho_RNA-bd", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR011114": {"description": "Holliday junction DNA helicase RuvA, C-terminal", "go_ids": ["GO:0005524", "GO:0006281", "GO:0006310", "GO:0009378", "GO:0009379"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0009378:four-way junction helicase activity:F", "GO:0009379:Holliday junction helicase complex:C"], "name": "RuvA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011115": {"description": "SecA DEAD-like, N-terminal", "go_ids": ["GO:0005524", "GO:0016020", "GO:0017038"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016020:membrane:C", "GO:0017038:protein import:P"], "name": "SecA_DEAD", "pathway_ids": ["R-HSA-9760173", "R-HSA-9636383", "R-HSA-1222387"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Domain"}, "IPR011116": {"description": "SecA Wing/Scaffold", "go_ids": ["GO:0016020", "GO:0017038"], "go_terms": ["GO:0016020:membrane:C", "GO:0017038:protein import:P"], "name": "SecA_Wing/Scaffold", "pathway_ids": ["R-HSA-9760173", "R-HSA-9636383", "R-HSA-1222387"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Domain"}, "IPR011118": {"description": "Tannase/feruloyl esterase", "go_ids": [], "go_terms": [], "name": "Tannase/feruloyl_esterase", "pathway_ids": ["PWY-6784"], "pathways": ["PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)"], "type": "Family"}, "IPR011119": {"description": "Uncharacterised domain, helicase/relaxase, putative", "go_ids": [], "go_terms": [], "name": "Unchr_helicase_relaxase_TraI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011120": {"description": "Neutral trehalase Ca2+ binding", "go_ids": ["GO:0004555", "GO:0005509", "GO:0005737", "GO:0005993"], "go_terms": ["GO:0004555:alpha,alpha-trehalase activity:F", "GO:0005509:calcium ion binding:F", "GO:0005737:cytoplasm:C", "GO:0005993:trehalose catabolic process:P"], "name": "Trehalase_Ca-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011121": {"description": "Tryptophan-rich domain", "go_ids": [], "go_terms": [], "name": "Trp-rich_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011122": {"description": "WavE lipopolysaccharide synthesis", "go_ids": [], "go_terms": [], "name": "WavE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011123": {"description": "Two component regulator three Y", "go_ids": [], "go_terms": [], "name": "Y_Y_Y", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011124": {"description": "Zinc finger, CW-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_CW", "pathway_ids": ["R-HSA-3214842", "R-HSA-5689603", "R-MMU-5689603", "R-HSA-9029569", "R-MMU-3214842", "R-MMU-75105", "R-HSA-9843970", "R-HSA-75105"], "pathways": ["R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-3214842:r:HDMs demethylate histones", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR011125": {"description": "Zinc finger, HypF-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_HypF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011126": {"description": "HPr(Ser) kinase/phosphorylase, N-terminal", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004672", "GO:0005524", "GO:0006109"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004672:protein kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006109:regulation of carbohydrate metabolic process:P"], "name": "Hpr_kin/Pase_Hpr_N", "pathway_ids": ["PWY-7039", "PWY-5107"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-5107:t:phytol salvage pathway"], "type": "Domain"}, "IPR011127": {"description": "D-alanine--D-alanine ligase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Dala_Dala_lig_N", "pathway_ids": ["PWY-7953", "PWY-6387", "PWY-6386"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "type": "Domain"}, "IPR011128": {"description": "Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal", "go_ids": ["GO:0016616", "GO:0046168", "GO:0051287"], "go_terms": ["GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F", "GO:0046168:glycerol-3-phosphate catabolic process:P", "GO:0051287:NAD binding:F"], "name": "G3P_DH_NAD-dep_N", "pathway_ids": ["PWY-5981", "PWY-7902", "PWY-5667", "R-MMU-1483166", "R-DRE-1483166", "R-SPO-1483166", "R-RNO-1483166", "R-CEL-1483166", "R-XTR-1483166", "R-HSA-1483166", "R-SCE-1483166", "R-DME-1483166"], "pathways": ["PWY-5981:t:CDP-diacylglycerol biosynthesis III", "PWY-7902:t:glucosylglycerol biosynthesis", "PWY-5667:t:CDP-diacylglycerol biosynthesis I", "R-MMU-1483166:r:Synthesis of PA", "R-DRE-1483166:r:Synthesis of PA", "R-SPO-1483166:r:Synthesis of PA", "R-RNO-1483166:r:Synthesis of PA", "R-CEL-1483166:r:Synthesis of PA", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-1483166:r:Synthesis of PA", "R-SCE-1483166:r:Synthesis of PA", "R-DME-1483166:r:Synthesis of PA"], "type": "Domain"}, "IPR011129": {"description": "Cold-shock domain", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "CSD", "pathway_ids": ["R-RNO-877300", "R-MMU-72203", "R-MMU-9770562", "R-RNO-9017802", "R-HSA-9918487", "R-RNO-72163", "R-HSA-9017802", "R-DRE-72163", "R-DRE-9770562", "R-RNO-72165", "R-DRE-877300", "R-HSA-72165", "R-BTA-877300", "R-HSA-9918481", "R-HSA-2173796", "R-BTA-72163", "R-HSA-72203", "R-BTA-72165", "R-HSA-9770562", "R-RNO-72203", "R-MMU-72163", "R-DRE-72203", "R-HSA-452723", "R-MMU-9017802", "R-MMU-877300", "R-HSA-72163", "R-MMU-72165", "R-HSA-9918476", "R-HSA-877300", "R-RNO-9770562", "R-BTA-9770562", "R-BTA-72203", "R-DRE-72165"], "pathways": ["R-RNO-877300:r:Interferon gamma signaling", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-DRE-9770562:r:mRNA Polyadenylation", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-DRE-877300:r:Interferon gamma signaling", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-877300:r:Interferon gamma signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-877300:r:Interferon gamma signaling", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-877300:r:Interferon gamma signaling", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DRE-72165:r:mRNA Splicing - Minor Pathway"], "type": "Domain"}, "IPR011130": {"description": "SecA, preprotein cross-linking domain", "go_ids": ["GO:0016020", "GO:0017038"], "go_terms": ["GO:0016020:membrane:C", "GO:0017038:protein import:P"], "name": "SecA_preprotein_X-link_dom", "pathway_ids": ["R-HSA-9760173", "R-HSA-9636383", "R-HSA-1222387"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Domain"}, "IPR011134": {"description": "Allophycocyanin linker protein", "go_ids": ["GO:0015979", "GO:0030089"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0030089:phycobilisome:C"], "name": "Allophyco_linker", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011138": {"description": "Succinate dehydrogenase cytochrome b558 subunit", "go_ids": [], "go_terms": [], "name": "Cytochrome_b-558", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011140": {"description": "Autonomous glycyl radical cofactor GrcA", "go_ids": [], "go_terms": [], "name": "Glycyl_radical_cofactor_GrcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011141": {"description": "Polyketide synthase, type III", "go_ids": ["GO:0009058", "GO:0016747"], "go_terms": ["GO:0009058:biosynthetic process:P", "GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "Polyketide_synthase_type-III", "pathway_ids": ["PWY-7397", "PWY-6515", "PWY-7897", "PWY-5135", "PWY-6316", "PWY-6787"], "pathways": ["PWY-7397:t:naringenin biosynthesis (engineered)", "PWY-6515:t:phloridzin biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5135:t:xanthohumol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6787:t:flavonoid biosynthesis (in equisetum)"], "type": "Family"}, "IPR011143": {"description": "Ganglioside GM2 synthase", "go_ids": ["GO:0016758", "GO:0000139"], "go_terms": ["GO:0016758:hexosyltransferase activity:F", "GO:0000139:Golgi membrane:C"], "name": "GM2_synthase", "pathway_ids": ["PWY-7836", "R-HSA-9037629", "R-HSA-9840309", "R-HSA-446203", "R-MMU-9037629", "R-RNO-9840309", "R-MMU-446203", "R-MMU-9840309"], "pathways": ["PWY-7836:t:ganglio-series glycosphingolipids biosynthesis", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-MMU-9037629:r:Lewis blood group biosynthesis", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-MMU-9840309:r:Glycosphingolipid biosynthesis"], "type": "Family"}, "IPR011145": {"description": "Scavenger mRNA decapping enzyme, N-terminal", "go_ids": ["GO:0000290", "GO:0016787"], "go_terms": ["GO:0000290:deadenylation-dependent decapping of nuclear-transcribed mRNA:P", "GO:0016787:hydrolase activity:F"], "name": "Scavenger_mRNA_decap_enz_N", "pathway_ids": ["R-SCE-429958", "R-HSA-429958", "R-SSC-429958", "R-SPO-429958", "R-CEL-429958", "R-RNO-429958", "R-MMU-429958"], "pathways": ["R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SSC-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Homologous_superfamily"}, "IPR011146": {"description": "HIT-like domain", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "HIT-like", "pathway_ids": ["R-MMU-9856649", "R-HSA-9013405", "R-RNO-9825892", "R-MMU-9824594", "R-HSA-9824594", "R-RNO-9856649", "R-CEL-9825892", "R-HSA-9856649", "R-CEL-9824594", "R-CEL-9856649", "R-RNO-9824594", "R-MMU-9825892", "R-HSA-9825892"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-MMU-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "type": "Domain"}, "IPR011147": {"description": "Bifunctional aspartokinase/homoserine dehydrogenase, homoserine dehydrogenase domain", "go_ids": ["GO:0004412"], "go_terms": ["GO:0004412:homoserine dehydrogenase activity:F"], "name": "Bifunc_Aspkin/hSer_DH", "pathway_ids": ["PWY-7977", "PWY-6562", "PWY-2942", "PWY-8088", "PWY-8296", "PWY-6559", "PWY-6160", "PWY-5097", "PWY-7153", "PWY-8179", "PWY-2941"], "pathways": ["PWY-7977:t:L-methionine biosynthesis IV", "PWY-6562:t:norspermidine biosynthesis", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8088:t:dipicolinate biosynthesis", "PWY-8296:t:cremeomycin biosynthesis", "PWY-6559:t:spermidine biosynthesis II", "PWY-6160:t:3-dehydroquinate biosynthesis II (archaea)", "PWY-5097:t:L-lysine biosynthesis VI", "PWY-7153:t:grixazone biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Domain"}, "IPR011149": {"description": "DNA polymerase II small subunit, archaeal", "go_ids": ["GO:0003676", "GO:0003887", "GO:0006260", "GO:0008408"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P", "GO:0008408:3'-5' exonuclease activity:F"], "name": "Pol2_small_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011150": {"description": "Cutinase, monofunctional", "go_ids": ["GO:0005576", "GO:0050525"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0050525:cutinase activity:F"], "name": "Cutinase_monf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011152": {"description": "Phosphoesterase MJ0912", "go_ids": [], "go_terms": [], "name": "Pesterase_MJ0912", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011159": {"description": "Phosphoprotein phosphatase PPZ/Ppq1", "go_ids": ["GO:0004722"], "go_terms": ["GO:0004722:protein serine/threonine phosphatase activity:F"], "name": "PPPtase_PPZ/Ppq1", "pathway_ids": ["R-SPO-9770562"], "pathways": ["R-SPO-9770562:r:mRNA Polyadenylation"], "type": "Family"}, "IPR011160": {"description": "Sphingomyelin phosphodiesterase", "go_ids": ["GO:0004767", "GO:0006685"], "go_terms": ["GO:0004767:sphingomyelin phosphodiesterase activity:F", "GO:0006685:sphingomyelin catabolic process:P"], "name": "Sphingomy_PDE", "pathway_ids": ["PWY-7277", "R-DDI-9840310", "R-MMU-9840310", "R-BTA-9840310", "R-CEL-9840310", "R-HSA-9840310"], "pathways": ["PWY-7277:t:sphingolipid biosynthesis (mammals)", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Family"}, "IPR011161": {"description": "MHC class I-like antigen recognition-like", "go_ids": [], "go_terms": [], "name": "MHC_I-like_Ag-recog", "pathway_ids": ["R-HSA-9610379", "R-HSA-6798695", "R-BTA-140875", "R-HSA-9705671", "R-RNO-198933", "R-MMU-5223345", "R-HSA-2424491", "R-HSA-2172127", "R-MMU-1236977", "R-RNO-140875", "R-HSA-1236977", "R-RNO-5223345", "R-HSA-140875", "R-HSA-164940", "R-BTA-202733", "R-HSA-8866654", "R-HSA-983170", "R-MMU-140875", "R-HSA-163125", "R-MMU-198933", "R-HSA-909733", "R-RNO-202733", "R-MMU-917977", "R-MMU-202733", "R-HSA-877300", "R-MMU-1236974", "R-MMU-983170", "R-HSA-1236974", "R-HSA-198933", "R-MMU-6798695", "R-HSA-917977", "R-HSA-5223345", "R-RNO-917977", "R-HSA-202733"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-2172127:r:DAP12 interactions", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-1236974:r:ER-Phagosome pathway", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR011162": {"description": "MHC classes I/II-like antigen recognition protein", "go_ids": [], "go_terms": [], "name": "MHC_I/II-like_Ag-recog", "pathway_ids": ["R-HSA-6798695", "R-HSA-2132295", "R-HSA-9705671", "R-SSC-202427", "R-HSA-202433", "R-RNO-202433", "R-RNO-140875", "R-RNO-5223345", "R-MMU-202430", "R-BTA-202733", "R-HSA-202427", "R-SSC-2132295", "R-RNO-202427", "R-RNO-202733", "R-SSC-202433", "R-MMU-202733", "R-MMU-2132295", "R-RNO-202424", "R-HSA-202430", "R-HSA-5223345", "R-RNO-917977", "R-MMU-202424", "R-HSA-9610379", "R-MMU-389948", "R-MMU-202433", "R-RNO-2132295", "R-BTA-140875", "R-RNO-198933", "R-MMU-5223345", "R-HSA-2424491", "R-HSA-2172127", "R-MMU-1236977", "R-HSA-1236977", "R-HSA-140875", "R-HSA-164940", "R-SSC-202424", "R-HSA-8866654", "R-HSA-983170", "R-MMU-140875", "R-HSA-163125", "R-MMU-198933", "R-SSC-202430", "R-HSA-909733", "R-HSA-389948", "R-MMU-917977", "R-HSA-877300", "R-MMU-1236974", "R-MMU-983170", "R-SSC-389948", "R-RNO-389948", "R-HSA-1236974", "R-HSA-198933", "R-MMU-6798695", "R-MMU-202427", "R-RNO-202430", "R-HSA-917977", "R-HSA-202424", "R-HSA-202733"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SSC-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-202433:r:Generation of second messenger molecules", "R-RNO-202433:r:Generation of second messenger molecules", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-2132295:r:MHC class II antigen presentation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-SSC-202433:r:Generation of second messenger molecules", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-202433:r:Generation of second messenger molecules", "R-RNO-2132295:r:MHC class II antigen presentation", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-2172127:r:DAP12 interactions", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-SSC-202424:r:Downstream TCR signaling", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-SSC-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-1236974:r:ER-Phagosome pathway", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SSC-389948:r:Co-inhibition by PD-1", "R-RNO-389948:r:Co-inhibition by PD-1", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Homologous_superfamily"}, "IPR011163": {"description": "Peptidase S1A, enteropeptidase", "go_ids": ["GO:0004252", "GO:0006508", "GO:0016020"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0016020:membrane:C"], "name": "Pept_S1A_enterop", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011166": {"description": "Beta-eliminating lyase family", "go_ids": ["GO:0009072", "GO:0016830"], "go_terms": ["GO:0009072:aromatic amino acid metabolic process:P", "GO:0016830:carbon-carbon lyase activity:F"], "name": "Beta-eliminating_lyase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011167": {"description": "Iron-dependent fumarate hydratase", "go_ids": ["GO:0004333", "GO:0006091"], "go_terms": ["GO:0004333:fumarate hydratase activity:F", "GO:0006091:generation of precursor metabolites and energy:P"], "name": "Fe_dep_fumarate_hydratase", "pathway_ids": ["PWY-8086", "PWY-7254", "PWY-6728", "PWY-5913", "PWY-7384", "PWY-561", "PWY-5690", "PWY-5392", "PWY-6969"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-6728:t:methylaspartate cycle", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)"], "type": "Family"}, "IPR011170": {"description": "Growth factor, vaccinia C11R type", "go_ids": ["GO:0005154"], "go_terms": ["GO:0005154:epidermal growth factor receptor binding:F"], "name": "GF_C11R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011171": {"description": "Glia maturation factor", "go_ids": ["GO:0071846", "GO:0071933"], "go_terms": ["GO:0071846:actin filament debranching:P", "GO:0071933:Arp2/3 complex binding:F"], "name": "GMF", "pathway_ids": ["R-SCE-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-SPO-6798695", "R-BTA-6798695", "R-DME-6798695", "R-RNO-6798695"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR011172": {"description": "Poxvirus, TNF-alpha receptor-II", "go_ids": ["GO:0052031", "GO:0005031", "GO:0033209"], "go_terms": ["GO:0052031:symbiont-mediated perturbation of host defense response:P", "GO:0005031:tumor necrosis factor receptor activity:F", "GO:0033209:tumor necrosis factor-mediated signaling pathway:P"], "name": "Poxvirus_TNF_rcpt-II", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011174": {"description": "Ezrin/radixin/moesin", "go_ids": ["GO:0003779"], "go_terms": ["GO:0003779:actin binding:F"], "name": "ERM", "pathway_ids": ["R-MMU-437239", "R-RNO-437239", "R-DME-437239", "R-HSA-9662361", "R-DME-5627123", "R-HSA-437239", "R-BTA-373752", "R-HSA-8950505", "R-HSA-2029482", "R-HSA-373752", "R-MMU-2029482", "R-DME-2029482", "R-HSA-5627123", "R-HSA-9662360", "R-MMU-5627123", "R-RNO-373752", "R-MMU-373752", "R-HSA-9725370", "R-DME-373752"], "pathways": ["R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-373752:r:Netrin-1 signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-373752:r:Netrin-1 signaling", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-373752:r:Netrin-1 signaling"], "type": "Family"}, "IPR011175": {"description": "Alpha-s2 casein", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Alpha-s2_casein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011176": {"description": "Complement control protein C3/B5", "go_ids": ["GO:0001848", "GO:0016020", "GO:0045916"], "go_terms": ["GO:0001848:complement binding:F", "GO:0016020:membrane:C", "GO:0045916:negative regulation of complement activation:P"], "name": "CCP_VACV_C3/B5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011177": {"description": "Transcription initiation factor TFIID subunit 1, animal", "go_ids": ["GO:0003677", "GO:0005669", "GO:0006352"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005669:transcription factor TFIID complex:C", "GO:0006352:DNA-templated transcription initiation:P"], "name": "TAF1_animal", "pathway_ids": ["R-CEL-73779", "R-MMU-75953", "R-DME-674695", "R-DME-76042", "R-MMU-6804756", "R-DME-73779", "R-MMU-674695", "R-DME-6804756", "R-HSA-167162", "R-CEL-674695", "R-HSA-167161", "R-DME-73776", "R-HSA-73776", "R-HSA-6804756", "R-HSA-75953", "R-HSA-167172", "R-CEL-75953", "R-MMU-73776", "R-HSA-76042", "R-HSA-674695", "R-DME-75953", "R-MMU-73779", "R-CEL-73776", "R-CEL-76042", "R-MMU-76042", "R-HSA-73779"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR011178": {"description": "Amyloidogenic glycoprotein, copper-binding", "go_ids": ["GO:0046914"], "go_terms": ["GO:0046914:transition metal ion binding:F"], "name": "Amyloid_glyco_Cu-bd", "pathway_ids": ["R-MMU-416476", "R-SSC-432720", "R-DME-381426", "R-HSA-879415", "R-MMU-9837999", "R-MMU-444473", "R-DME-8957275", "R-HSA-3000178", "R-HSA-977225", "R-HSA-933542", "R-RNO-444473", "R-SSC-114608", "R-HSA-8862803", "R-CEL-3000178", "R-HSA-416476", "R-MMU-933542", "R-RNO-9609523", "R-DME-3000178", "R-MMU-418594", "R-MMU-8957275", "R-RNO-114608", "R-RNO-418594", "R-CEL-416476", "R-HSA-114608", "R-CEL-9609523", "R-MMU-445989", "R-MMU-3000178", "R-RNO-8957275", "R-SSC-933542", "R-MMU-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-444473", "R-DME-9609523", "R-HSA-9837999", "R-MMU-432720", "R-HSA-9609523", "R-MMU-9609523", "R-SSC-445989", "R-RNO-416476", "R-RNO-3000178", "R-HSA-381426", "R-SSC-3000178", "R-HSA-844456", "R-SSC-381426", "R-SSC-8957275", "R-RNO-432720", "R-HSA-432720", "R-DME-114608", "R-DME-9837999", "R-HSA-9660826", "R-MMU-879415", "R-HSA-445989", "R-SSC-9609523", "R-CEL-114608", "R-RNO-9837999", "R-SSC-879415", "R-RNO-381426", "R-HSA-418594", "R-RNO-879415", "R-RNO-445989", "R-SSC-9837999", "R-HSA-8957275", "R-RNO-933542", "R-MMU-114608"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-SSC-114608:r:Platelet degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-3000178:r:ECM proteoglycans", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-416476:r:G alpha (q) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-HSA-844456:r:The NLRP3 inflammasome", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-114608:r:Platelet degranulation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-114608:r:Platelet degranulation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR011179": {"description": "Isopentenyl-diphosphate delta-isomerase, FMN-dependent", "go_ids": ["GO:0004452", "GO:0008299", "GO:0010181"], "go_terms": ["GO:0004452:isopentenyl-diphosphate delta-isomerase activity:F", "GO:0008299:isoprenoid biosynthetic process:P", "GO:0010181:FMN binding:F"], "name": "IPdP_isomerase", "pathway_ids": ["PWY-7102", "PWY-7524", "PWY-6859", "PWY-6383", "PWY-7391", "PWY-7560", "PWY-922", "PWY-8125", "PWY-6174"], "pathways": ["PWY-7102:t:bisabolene biosynthesis (engineered)", "PWY-7524:t:mevalonate pathway III (Thermoplasma)", "PWY-6859:t:all-trans-farnesol biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-7560:t:methylerythritol phosphate pathway II", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "PWY-8125:t:mevalonate pathway IV (archaea)", "PWY-6174:t:mevalonate pathway II (haloarchaea)"], "type": "Family"}, "IPR011181": {"description": "Protein VP3, rotavirus", "go_ids": ["GO:0005525", "GO:0016032", "GO:0019013", "GO:0004482"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0016032:viral process:P", "GO:0019013:viral nucleocapsid:C", "GO:0004482:mRNA 5'-cap (guanine-N7-)-methyltransferase activity:F"], "name": "VP3_Rotav", "pathway_ids": ["PWY-7119", "PWY-7375", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978", "R-HSA-8983711"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7375:t:mRNA capping I", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I", "R-HSA-8983711:r:OAS antiviral response"], "type": "Family"}, "IPR011182": {"description": "L-aspartate dehydrogenase", "go_ids": ["GO:0009435", "GO:0033735"], "go_terms": ["GO:0009435:NAD+ biosynthetic process:P", "GO:0033735:L-aspartate dehydrogenase [NAD(P)+] activity:F"], "name": "L-Asp_DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011183": {"description": "Pyrophosphate-dependent phosphofructokinase PfpB", "go_ids": ["GO:0005524", "GO:0006096", "GO:0047334"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006096:glycolytic process:P", "GO:0047334:diphosphate-fructose-6-phosphate 1-phosphotransferase activity:F"], "name": "PfpB_PPi_PFK", "pathway_ids": ["PWY-1042", "PWY-8178"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II"], "type": "Family"}, "IPR011184": {"description": "DNA mismatch repair Msh2-type", "go_ids": ["GO:0005524", "GO:0006298", "GO:0030983"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006298:mismatch repair:P", "GO:0030983:mismatched DNA binding:F"], "name": "DNA_mismatch_repair_Msh2", "pathway_ids": ["R-BTA-5358606", "R-HSA-5632968", "R-RNO-5358565", "R-BTA-5358565", "R-SPO-5358565", "R-SCE-5358565", "R-HSA-912446", "R-HSA-5632927", "R-SPO-5358606", "R-HSA-5358606", "R-HSA-5358565", "R-SCE-5358606", "R-DDI-5358565", "R-HSA-6796648", "R-MMU-5358606", "R-DME-5358565", "R-MMU-5358565", "R-HSA-5632928"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2"], "type": "Family"}, "IPR011188": {"description": "Peptidoglycan synthesis regulatory protein ReoY-like", "go_ids": [], "go_terms": [], "name": "ReoY-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011189": {"description": "Uncharacterised conserved protein, caspase-like", "go_ids": [], "go_terms": [], "name": "UCP_caspase_lke", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011190": {"description": "N-acetylglutamate synthase, fungal", "go_ids": ["GO:0004042"], "go_terms": ["GO:0004042:L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor:F"], "name": "GlcNAc_Synth_fun", "pathway_ids": ["PWY-5154"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Family"}, "IPR011191": {"description": "Uncharacterised protein family Treponema vWA", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Tp_vWA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011192": {"description": "Rubisco LSMT methyltransferase, plant", "go_ids": ["GO:0009507", "GO:0030785"], "go_terms": ["GO:0009507:chloroplast:C", "GO:0030785:[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity:F"], "name": "Rubisco_LSMT_MeTrfase_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011193": {"description": "Ornithine/lysine/arginine decarboxylase", "go_ids": ["GO:0005737", "GO:0006520", "GO:0016831"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006520:amino acid metabolic process:P", "GO:0016831:carboxy-lyase activity:F"], "name": "Orn/lys/arg_de-COase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011194": {"description": "Uncharacterised protein family UPF0306", "go_ids": [], "go_terms": [], "name": "UPF0306", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011195": {"description": "Uncharacterised conserved protein UCP010256", "go_ids": [], "go_terms": [], "name": "UCP010256", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011197": {"description": "Uncharacterised conserved protein UCP012318", "go_ids": [], "go_terms": [], "name": "UCP012318", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011199": {"description": "Bacillithiol biosynthesis BshC", "go_ids": [], "go_terms": [], "name": "Bacillithiol_biosynth_BshC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011200": {"description": "Uncharacterised conserved protein UCP012608", "go_ids": [], "go_terms": [], "name": "UCP012608", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011201": {"description": "Zinc-ribbon domain, bacteria", "go_ids": [], "go_terms": [], "name": "Zinc-ribbon_6_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011202": {"description": "Uncharacterised conserved protein UCP014677", "go_ids": [], "go_terms": [], "name": "UCP014677", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011204": {"description": "Virulence protein RhuM-like", "go_ids": [], "go_terms": [], "name": "Virulence_RhuM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011205": {"description": "Uncharacterised conserved protein UCP015417, vWA", "go_ids": [], "go_terms": [], "name": "UCP015417_vWA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011206": {"description": "Citrate lyase beta subunit-like", "go_ids": [], "go_terms": [], "name": "Citrate_lyase_beta/mcl1/mcl2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011207": {"description": "Orthopoxvirus protein F1", "go_ids": ["GO:0033668"], "go_terms": ["GO:0033668:symbiont-mediated suppression of host apoptosis:P"], "name": "Orthopox_F1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011212": {"description": "Poxvirus, Protein B14/B22/C16", "go_ids": [], "go_terms": [], "name": "Poxvirus_B14/B22/C16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011213": {"description": "Nicotinic acid mononucleotide biosynthesis protein", "go_ids": [], "go_terms": [], "name": "NMN_biosyn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011214": {"description": "Uncharacterised conserved protein UCP020967", "go_ids": [], "go_terms": [], "name": "UCP020967", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011215": {"description": "Cysteine protease StiP, N-terminal domain", "go_ids": [], "go_terms": [], "name": "StiP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011217": {"description": "Virginiamycin B lyase Vgb", "go_ids": ["GO:0000287", "GO:0016835", "GO:0017001", "GO:0046677"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0016835:carbon-oxygen lyase activity:F", "GO:0017001:antibiotic catabolic process:P", "GO:0046677:response to antibiotic:P"], "name": "Vgb_bact", "pathway_ids": ["PWY-5397"], "pathways": ["PWY-5397:t:crocetin biosynthesis"], "type": "Family"}, "IPR011218": {"description": "Pesticidal crystal protein Cry15Aa", "go_ids": [], "go_terms": [], "name": "Cry15Aa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011219": {"description": "Rubisco-cytochrome methylase MET", "go_ids": [], "go_terms": [], "name": "Rubisco-cyt_methylase_MET", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011220": {"description": "Uncharacterised conserved protein UCP028205", "go_ids": [], "go_terms": [], "name": "UCP028205", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011222": {"description": "Double-stranded DNA virus, group I, capsid", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "dsDNA_vir_gr_I_capsid", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011223": {"description": "Uncharacterised conserved protein UCP028770", "go_ids": [], "go_terms": [], "name": "UCP028770", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011224": {"description": "Ribosomal RNA large subunit methyltransferase M", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "rRNA_MeTrfase_M", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011225": {"description": "Type IV secretory pathway, VirJ component", "go_ids": [], "go_terms": [], "name": "IV_sec_VirJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011226": {"description": "ATP-grasp family", "go_ids": [], "go_terms": [], "name": "ATP-grasp_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011227": {"description": "Uncharacterised conserved protein UCP029730", "go_ids": [], "go_terms": [], "name": "UCP029730", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011228": {"description": "Uncharacterised conserved protein UCP029766", "go_ids": [], "go_terms": [], "name": "UCP029766", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011229": {"description": "Cell cycle protein GpsB", "go_ids": [], "go_terms": [], "name": "Cell_cycle_GpsB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011230": {"description": "Probable inactive purple acid phosphatase 14/16/28/29", "go_ids": [], "go_terms": [], "name": "PAP14/16/28/29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011231": {"description": "Bacteriophage VT1-Sakai, H0018", "go_ids": [], "go_terms": [], "name": "Phage_VT1-Sakai_H0018", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011233": {"description": "Probable tellurium resistance transcriptional regulator TerW", "go_ids": [], "go_terms": [], "name": "TerW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011234": {"description": "Fumarylacetoacetase-like, C-terminal", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Fumarylacetoacetase-like_C", "pathway_ids": ["R-MMU-70268", "R-HSA-8963684", "R-CEL-70268", "R-RNO-70268", "R-DDI-70268", "R-RNO-8963684", "R-SPO-70268", "R-MMU-8963684", "R-CEL-8963684", "R-DDI-8963684", "R-HSA-70268", "R-BTA-70268", "R-SCE-70268"], "pathways": ["R-MMU-70268:r:Pyruvate metabolism", "R-HSA-8963684:r:Tyrosine catabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-RNO-70268:r:Pyruvate metabolism", "R-DDI-70268:r:Pyruvate metabolism", "R-RNO-8963684:r:Tyrosine catabolism", "R-SPO-70268:r:Pyruvate metabolism", "R-MMU-8963684:r:Tyrosine catabolism", "R-CEL-8963684:r:Tyrosine catabolism", "R-DDI-8963684:r:Tyrosine catabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Domain"}, "IPR011235": {"description": "MepB-like", "go_ids": [], "go_terms": [], "name": "MepB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011238": {"description": "Bacterial microcompartment shell protein PduT", "go_ids": [], "go_terms": [], "name": "Micro_shell_prot_PduT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011239": {"description": "Phosphoesterase cyanobacterial, all2852", "go_ids": [], "go_terms": [], "name": "Pesterase_cyn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011240": {"description": "Phosphoesterase-related protein YunD", "go_ids": [], "go_terms": [], "name": "Pesterase_YunD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011241": {"description": "Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase", "go_ids": ["GO:0003942", "GO:0003991", "GO:0005739", "GO:0006526"], "go_terms": ["GO:0003942:N-acetyl-gamma-glutamyl-phosphate reductase activity:F", "GO:0003991:acetylglutamate kinase activity:F", "GO:0005739:mitochondrion:C", "GO:0006526:L-arginine biosynthetic process:P"], "name": "NAGK/NAGSA", "pathway_ids": ["PWY-5154", "R-DDI-70635", "R-SCE-70635", "R-SPO-70635"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-DDI-70635:r:Urea cycle", "R-SCE-70635:r:Urea cycle", "R-SPO-70635:r:Urea cycle"], "type": "Family"}, "IPR011242": {"description": "Acetylglutamate kinase ArgB, GNAT domain-containing", "go_ids": ["GO:0003991", "GO:0005737", "GO:0006526"], "go_terms": ["GO:0003991:acetylglutamate kinase activity:F", "GO:0005737:cytoplasm:C", "GO:0006526:L-arginine biosynthetic process:P"], "name": "ArgB_GNAT", "pathway_ids": ["PWY-5154"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Family"}, "IPR011243": {"description": "N-acetylglutamate synthase, animal", "go_ids": ["GO:0004042", "GO:0006526"], "go_terms": ["GO:0004042:L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor:F", "GO:0006526:L-arginine biosynthetic process:P"], "name": "GlcNAc_Synth_met", "pathway_ids": ["PWY-5154", "R-MMU-70635", "R-DRE-70635", "R-HSA-70635", "R-HSA-9955693"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-MMU-70635:r:Urea cycle", "R-DRE-70635:r:Urea cycle", "R-HSA-70635:r:Urea cycle", "R-HSA-9955693:r:NAGS variants cause NAGS deficiency"], "type": "Family"}, "IPR011244": {"description": "Bifunctional argininosuccinate lyase/acetyltransferase", "go_ids": ["GO:0004056", "GO:0005737", "GO:0006526", "GO:0016746"], "go_terms": ["GO:0004056:argininosuccinate lyase activity:F", "GO:0005737:cytoplasm:C", "GO:0006526:L-arginine biosynthetic process:P", "GO:0016746:acyltransferase activity:F"], "name": "ASAL_AGS_AcTrfase", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-7400", "PWY-7692", "PWY-6310", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-4983", "PWY-7687", "PWY-7818", "PWY-8407", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-5154", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-5", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-5903", "PWY-8058", "PWY-8366", "PWY-8327", "PWY-4984", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-7692:t:bikaverin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-4983:t:nitric oxide biosynthesis II (mammals)", "PWY-7687:t:stipitatate biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8407:t:fumagillin biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-5:t:canavanine biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-4984:t:urea cycle", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR011245": {"description": "Butyrate kinase", "go_ids": ["GO:0005524", "GO:0005737", "GO:0016310", "GO:0047761"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0016310:phosphorylation:P", "GO:0047761:butyrate kinase activity:F"], "name": "Butyrate_kin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011246": {"description": "Bifunctional diaminopimelate decarboxylase/aspartate kinase", "go_ids": [], "go_terms": [], "name": "DAP_dec_asp_kin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011247": {"description": "Chemotaxis protein-glutamate methylesterase", "go_ids": [], "go_terms": [], "name": "Chemotax_prot-Glu_Me-esterase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011248": {"description": "Serine/alanine racemase", "go_ids": ["GO:0016020", "GO:0016855", "GO:0030170", "GO:0046677"], "go_terms": ["GO:0016020:membrane:C", "GO:0016855:racemase and epimerase activity, acting on amino acids and derivatives:F", "GO:0030170:pyridoxal phosphate binding:F", "GO:0046677:response to antibiotic:P"], "name": "Serine/alanine_racemase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011249": {"description": "Metalloenzyme, LuxS/M16 peptidase-like", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Metalloenz_LuxS/M16", "pathway_ids": ["PWY-6154", "PWY-6151", "PWY-6153", "R-MMU-9837999", "R-DDI-611105", "R-BTA-5689880", "R-HSA-5689880", "R-HSA-77387", "R-CEL-9865881", "R-RNO-8949664", "R-MMU-8949664", "R-MMU-9865881", "R-BTA-9033241", "R-MMU-5689880", "R-RNO-9033241", "R-HSA-1268020", "R-BTA-9837999", "R-MMU-1268020", "R-SCE-9033241", "R-MMU-611105", "R-SPO-611105", "R-HSA-8949664", "R-HSA-9837999", "R-BTA-9865881", "R-SCE-1268020", "R-DDI-9033241", "R-DDI-9837999", "R-MMU-77387", "R-HSA-9865881", "R-BTA-8949664", "R-DRE-1268020", "R-CEL-9837999", "R-DME-9033241", "R-XTR-1268020", "R-RNO-9837999", "R-MMU-9033241", "R-SPO-1268020", "R-RNO-77387", "R-RNO-5689880", "R-SCE-9865878", "R-RNO-611105", "R-SPO-9033241", "R-HSA-611105", "R-SPO-9837999", "R-SCE-9837999", "R-CEL-611105", "R-CEL-8949664", "R-RNO-9865881", "R-SCE-611105", "R-BTA-77387", "R-DME-1268020", "R-HSA-9033241", "R-DME-5689880", "R-BTA-611105"], "pathways": ["PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-6151:t:S-adenosyl-L-methionine salvage I", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-611105:r:Respiratory electron transport", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-77387:r:Insulin receptor recycling", "R-CEL-9865881:r:Complex III assembly", "R-RNO-8949664:r:Processing of SMDT1", "R-MMU-8949664:r:Processing of SMDT1", "R-MMU-9865881:r:Complex III assembly", "R-BTA-9033241:r:Peroxisomal protein import", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-1268020:r:Mitochondrial protein import", "R-SCE-9033241:r:Peroxisomal protein import", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-HSA-8949664:r:Processing of SMDT1", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-9865881:r:Complex III assembly", "R-SCE-1268020:r:Mitochondrial protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-9865881:r:Complex III assembly", "R-BTA-8949664:r:Processing of SMDT1", "R-DRE-1268020:r:Mitochondrial protein import", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DME-9033241:r:Peroxisomal protein import", "R-XTR-1268020:r:Mitochondrial protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-SPO-1268020:r:Mitochondrial protein import", "R-RNO-77387:r:Insulin receptor recycling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-611105:r:Respiratory electron transport", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-611105:r:Respiratory electron transport", "R-CEL-8949664:r:Processing of SMDT1", "R-RNO-9865881:r:Complex III assembly", "R-SCE-611105:r:Respiratory electron transport", "R-BTA-77387:r:Insulin receptor recycling", "R-DME-1268020:r:Mitochondrial protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-5689880:r:Ub-specific processing proteases", "R-BTA-611105:r:Respiratory electron transport"], "type": "Homologous_superfamily"}, "IPR011250": {"description": "Outer membrane protein/outer membrane enzyme PagP, beta-barrel", "go_ids": [], "go_terms": [], "name": "OMP/PagP_B-barrel", "pathway_ids": ["R-HSA-202733"], "pathways": ["R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Homologous_superfamily"}, "IPR011251": {"description": "Luciferase-like domain", "go_ids": ["GO:0016705"], "go_terms": ["GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F"], "name": "Luciferase-like_dom", "pathway_ids": ["R-HSA-1222541"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis"], "type": "Domain"}, "IPR011252": {"description": "Fibrogen-binding domain 1", "go_ids": ["GO:0007155"], "go_terms": ["GO:0007155:cell adhesion:P"], "name": "Fibrogen-bd_dom1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011254": {"description": "Prismane-like superfamily", "go_ids": ["GO:0003824", "GO:0016491"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0016491:oxidoreductase activity:F"], "name": "Prismane-like_sf", "pathway_ids": ["R-SCE-6791226"], "pathways": ["R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Homologous_superfamily"}, "IPR011256": {"description": "Regulatory factor, effector binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Reg_factor_effector_dom_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-114608", "R-HSA-418594", "R-MMU-444473", "R-XTR-444473", "R-HSA-444473", "R-XTR-418594", "R-MMU-425986", "R-MMU-6798695", "R-MMU-418594", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-XTR-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-XTR-418594:r:G alpha (i) signalling events", "R-MMU-425986:r:Sodium/Proton exchangers", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR011257": {"description": "DNA glycosylase", "go_ids": ["GO:0003824", "GO:0006281"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0006281:DNA repair:P"], "name": "DNA_glycosylase", "pathway_ids": ["R-HSA-110357", "R-MMU-5649702", "R-HSA-9656256", "R-SCE-110329", "R-DME-110357", "R-HSA-5649702", "R-MMU-110331", "R-CEL-110329", "R-HSA-110331", "R-HSA-9657050", "R-BTA-110357", "R-MMU-110329", "R-HSA-110329", "R-RNO-110330", "R-HSA-110330", "R-CEL-110357", "R-DME-110330", "R-SPO-110331", "R-MMU-110357", "R-HSA-9630222", "R-HSA-9656255", "R-SCE-110330", "R-MMU-110330", "R-DME-110329", "R-HSA-9608287", "R-RNO-110331", "R-HSA-110328", "R-HSA-9608290", "R-RNO-110357", "R-BTA-110329", "R-DME-110331", "R-RNO-5649702", "R-SPO-110329", "R-SCE-110331", "R-RNO-110329", "R-HSA-9630221"], "pathways": ["R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-9656256:r:Defective OGG1 Substrate Processing", "R-SCE-110329:r:Cleavage of the damaged pyrimidine", "R-DME-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110331:r:Cleavage of the damaged purine", "R-CEL-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-9657050:r:Defective OGG1 Localization", "R-BTA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-CEL-110357:r:Displacement of DNA glycosylase by APEX1", "R-DME-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-SPO-110331:r:Cleavage of the damaged purine", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9630222:r:Defective NTHL1 substrate binding", "R-HSA-9656255:r:Defective OGG1 Substrate Binding", "R-SCE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-DME-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-9608287:r:Defective MUTYH substrate binding", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9608290:r:Defective MUTYH substrate processing", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-BTA-110329:r:Cleavage of the damaged pyrimidine", "R-DME-110331:r:Cleavage of the damaged purine", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-SPO-110329:r:Cleavage of the damaged pyrimidine", "R-SCE-110331:r:Cleavage of the damaged purine", "R-RNO-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-9630221:r:Defective NTHL1 substrate processing"], "type": "Homologous_superfamily"}, "IPR011258": {"description": "BPG-independent PGAM, core domain", "go_ids": ["GO:0004619", "GO:0005737", "GO:0006007", "GO:0030145"], "go_terms": ["GO:0004619:phosphoglycerate mutase activity:F", "GO:0005737:cytoplasm:C", "GO:0006007:glucose catabolic process:P", "GO:0030145:manganese ion binding:F"], "name": "BPG-indep_PGM_core", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-2221", "PWY-7124", "PWY-6886", "PWY-6142", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901", "PWY-5484", "PWY-8362"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-8362:t:photorespiration II"], "type": "Domain"}, "IPR011259": {"description": "Ezrin/radixin/moesin, C-terminal", "go_ids": [], "go_terms": [], "name": "ERM_C_dom", "pathway_ids": ["R-MMU-437239", "R-RNO-437239", "R-DME-437239", "R-HSA-9662361", "R-DME-5627123", "R-HSA-437239", "R-BTA-373752", "R-HSA-8950505", "R-HSA-2029482", "R-HSA-373752", "R-MMU-2029482", "R-DME-2029482", "R-HSA-5627123", "R-HSA-9662360", "R-MMU-5627123", "R-RNO-373752", "R-MMU-373752", "R-HSA-9725370", "R-DME-373752"], "pathways": ["R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-373752:r:Netrin-1 signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-373752:r:Netrin-1 signaling", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-373752:r:Netrin-1 signaling"], "type": "Domain"}, "IPR011260": {"description": "RNA polymerase, alpha subunit, C-terminal", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "RNAP_asu_C", "pathway_ids": ["R-HSA-9639775"], "pathways": ["R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb"], "type": "Domain"}, "IPR011262": {"description": "DNA-directed RNA polymerase, insert domain", "go_ids": ["GO:0003899", "GO:0006351", "GO:0046983"], "go_terms": ["GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P", "GO:0046983:protein dimerization activity:F"], "name": "DNA-dir_RNA_pol_insert", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-MMU-9770562", "R-HSA-73980", "R-HSA-427413", "R-DDI-73776", "R-BTA-76071", "R-SPO-6781823", "R-DDI-6782210", "R-DDI-72163", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-BTA-76066", "R-BTA-9018519", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-DDI-674695", 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"R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-HSA-76042", "R-HSA-674695", "R-SCE-73772", "R-SPO-72163", "R-BTA-6807505", "R-BTA-72203", "R-HSA-112382", "R-HSA-73779", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-BTA-76042", "R-SPO-6807505", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-BTA-76061", "R-HSA-167246", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-SPO-73762", "R-HSA-5601884", "R-SPO-75953", "R-SPO-113418", "R-MMU-5250924", "R-DDI-73779", "R-BTA-72086", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-MMU-9018519", "R-DDI-6807505", "R-SPO-9770562", "R-HSA-167200", "R-SCE-73762", "R-SCE-674695", "R-BTA-9770562", "R-MMU-6782210", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-SCE-76066", "R-MMU-73762", "R-MMU-6782135", "R-HSA-76066", "R-BTA-113418", 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"R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", 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"R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-HSA-76042", "R-HSA-674695", "R-SCE-73772", "R-SPO-72163", "R-BTA-6807505", "R-BTA-72203", "R-HSA-112382", "R-HSA-73779", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-BTA-76042", "R-SPO-6807505", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-BTA-76061", "R-HSA-167246", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-SPO-73762", "R-HSA-5601884", "R-SPO-75953", "R-SPO-113418", "R-MMU-5250924", "R-DDI-73779", "R-BTA-72086", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-MMU-9018519", "R-DDI-6807505", "R-SPO-9770562", "R-HSA-167200", "R-SCE-73762", "R-SCE-674695", "R-BTA-9770562", "R-MMU-6782210", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-SCE-76066", "R-MMU-73762", "R-MMU-6782135", "R-HSA-76066", "R-BTA-113418", "R-HSA-9639775", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-DDI-76061", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-BTA-112382", "R-SCE-6782210", "R-HSA-9918481", "R-BTA-6796648", "R-SCE-72203", "R-SCE-6796648", "R-SPO-72203", "R-BTA-73762", "R-SPO-77075", "R-SCE-113418", "R-SCE-72086", "R-MMU-73863", "R-HSA-6782135", "R-HSA-73762", "R-SCE-77075", "R-HSA-5250924", "R-DDI-75953", "R-SPO-6782135"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair 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at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", 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ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER"], "type": "Domain"}, "IPR011264": {"description": "Betaine aldehyde dehydrogenase", "go_ids": ["GO:0046872", "GO:0008802"], "go_terms": ["GO:0046872:metal ion binding:F", "GO:0008802:betaine-aldehyde dehydrogenase (NAD+) activity:F"], "name": "BADH", "pathway_ids": ["PWY-5760", "PWY-6054", "PWY-3722", "PWY-6055", "PWY-7494", "PWY-3981"], "pathways": ["PWY-5760:t:beta-alanine biosynthesis IV", "PWY-6054:t:dimethylsulfoniopropanoate biosynthesis I (Wollastonia)", "PWY-3722:t:glycine betaine biosynthesis II (Gram-positive bacteria)", "PWY-6055:t:dimethylsulfoniopropanoate biosynthesis II (Spartina)", "PWY-7494:t:choline degradation IV", "PWY-3981:t:beta-alanine biosynthesis I"], "type": "Family"}, "IPR011265": {"description": "GABA permease", "go_ids": ["GO:0015185", "GO:0015812", "GO:0016020"], "go_terms": ["GO:0015185:gamma-aminobutyric acid transmembrane transporter activity:F", "GO:0015812:gamma-aminobutyric acid transport:P", "GO:0016020:membrane:C"], "name": "GABA_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011266": {"description": "Fibrinogen-binding domain 2", "go_ids": ["GO:0005618", "GO:0007155"], "go_terms": ["GO:0005618:cell wall:C", "GO:0007155:cell adhesion:P"], "name": "Adhesin_Fg-bd_dom_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011267": {"description": "Vegetative storage protein", "go_ids": ["GO:0045735"], "go_terms": ["GO:0045735:nutrient reservoir activity:F"], "name": "Veg_Stor_Prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011268": {"description": "Purine nucleoside phosphorylase", "go_ids": ["GO:0004731", "GO:0006139"], "go_terms": ["GO:0004731:purine-nucleoside phosphorylase activity:F", "GO:0006139:nucleobase-containing compound metabolic process:P"], "name": "Purine_phosphorylase", "pathway_ids": ["PWY-4202", "PWY-5695", "PWY-6611", "PWY-7179", "PWY-6608", "PWY-6609", "PWY-5532", "PWY-6627", "PWY-8440", "PWY-6620", "PWY-6644", "R-HSA-6798695", "R-SPO-6798695", "R-SCE-9755088", "R-RNO-74259", "R-RNO-74217", "R-RNO-9755088", "R-SCE-6798695", "R-MMU-9755088", "R-SCE-74217", "R-HSA-74259", "R-MMU-74217", "R-SPO-9755088", "R-HSA-74217", "R-MMU-6798695", "R-MMU-74259", "R-SCE-74259", "R-HSA-9755088", "R-SPO-74259", "R-HSA-9735763", "R-SPO-74217", "R-RNO-6798695"], "pathways": ["PWY-4202:t:arsenic detoxification (mammals)", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6611:t:adenine and adenosine salvage V", "PWY-7179:t:purine deoxyribonucleosides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6609:t:adenine and adenosine salvage III", "PWY-5532:t:nucleoside and nucleotide degradation (archaea)", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8440:t:nucleoside and nucleotide degradation (halobacteria)", "PWY-6620:t:guanine and guanosine salvage I", "PWY-6644:t:fluoroacetate and fluorothreonine biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SCE-9755088:r:Ribavirin ADME", "R-RNO-74259:r:Purine catabolism", "R-RNO-74217:r:Purine salvage", "R-RNO-9755088:r:Ribavirin ADME", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9755088:r:Ribavirin ADME", "R-SCE-74217:r:Purine salvage", "R-HSA-74259:r:Purine catabolism", "R-MMU-74217:r:Purine salvage", "R-SPO-9755088:r:Ribavirin ADME", "R-HSA-74217:r:Purine salvage", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-74259:r:Purine catabolism", "R-SCE-74259:r:Purine catabolism", "R-HSA-9755088:r:Ribavirin ADME", "R-SPO-74259:r:Purine catabolism", "R-HSA-9735763:r:Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine", "R-SPO-74217:r:Purine salvage", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR011269": {"description": "Putative purine nucleotide phosphorylase", "go_ids": ["GO:0004731", "GO:0006139"], "go_terms": ["GO:0004731:purine-nucleoside phosphorylase activity:F", "GO:0006139:nucleobase-containing compound metabolic process:P"], "name": "PUNP", "pathway_ids": ["PWY-4202", "PWY-5695", "PWY-6611", "PWY-7179", "PWY-6608", "PWY-6609", "PWY-5532", "PWY-6627", "PWY-8440", "PWY-6620", "PWY-6644"], "pathways": ["PWY-4202:t:arsenic detoxification (mammals)", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6611:t:adenine and adenosine salvage V", "PWY-7179:t:purine deoxyribonucleosides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6609:t:adenine and adenosine salvage III", "PWY-5532:t:nucleoside and nucleotide degradation (archaea)", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8440:t:nucleoside and nucleotide degradation (halobacteria)", "PWY-6620:t:guanine and guanosine salvage I", "PWY-6644:t:fluoroacetate and fluorothreonine biosynthesis"], "type": "Family"}, "IPR011270": {"description": "Purine nucleoside phosphorylase I, inosine/guanosine-specific", "go_ids": ["GO:0004731", "GO:0006139"], "go_terms": ["GO:0004731:purine-nucleoside phosphorylase activity:F", "GO:0006139:nucleobase-containing compound metabolic process:P"], "name": "Pur_Nuc_Pase_Ino/Guo-sp", "pathway_ids": ["PWY-4202", "PWY-5695", "PWY-6611", "PWY-7179", "PWY-6608", "PWY-6609", "PWY-5532", "PWY-6627", "PWY-8440", "PWY-6620", "PWY-6644", "R-MMU-9755088", "R-HSA-6798695", "R-SPO-6798695", "R-HSA-74259", "R-RNO-9755088", "R-RNO-74259", "R-MMU-74217", "R-RNO-74217", "R-SPO-9755088", "R-HSA-74217", "R-MMU-6798695", "R-MMU-74259", "R-SPO-74259", "R-HSA-9755088", "R-HSA-9735763", "R-SPO-74217", "R-RNO-6798695"], "pathways": ["PWY-4202:t:arsenic detoxification (mammals)", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6611:t:adenine and adenosine salvage V", "PWY-7179:t:purine deoxyribonucleosides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6609:t:adenine and adenosine salvage III", "PWY-5532:t:nucleoside and nucleotide degradation (archaea)", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8440:t:nucleoside and nucleotide degradation (halobacteria)", "PWY-6620:t:guanine and guanosine salvage I", "PWY-6644:t:fluoroacetate and fluorothreonine biosynthesis", "R-MMU-9755088:r:Ribavirin ADME", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-74259:r:Purine catabolism", "R-RNO-9755088:r:Ribavirin ADME", "R-RNO-74259:r:Purine catabolism", "R-MMU-74217:r:Purine salvage", "R-RNO-74217:r:Purine salvage", "R-SPO-9755088:r:Ribavirin ADME", "R-HSA-74217:r:Purine salvage", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-74259:r:Purine catabolism", "R-SPO-74259:r:Purine catabolism", "R-HSA-9755088:r:Ribavirin ADME", "R-HSA-9735763:r:Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine", "R-SPO-74217:r:Purine salvage", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, 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"Malate dehydrogenase, NAD-dependent, cytosolic", "go_ids": ["GO:0006108", "GO:0030060"], "go_terms": ["GO:0006108:malate metabolic process:P", "GO:0030060:L-malate dehydrogenase (NAD+) activity:F"], "name": "Malate_DH_NAD-dep_euk", "pathway_ids": ["PWY-7383", "PWY-8086", "PWY-1622", "PWY-6728", "PWY-7115", "PWY-561", "PWY-5690", "PWY-5392", "PWY-6969", "R-DDI-9856872", "R-HSA-9856872", "R-SSC-9856872", "R-MMU-9856872", "R-XTR-9856872", "R-RNO-9856872", "R-GGA-352875", "R-CEL-9856872", "R-BTA-9856872"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-6728:t:methylaspartate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", 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"R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Family"}, "IPR011282": {"description": "2-amino-3-ketobutyrate coenzyme A ligase", "go_ids": ["GO:0008890", "GO:0006567"], "go_terms": ["GO:0008890:glycine C-acetyltransferase activity:F", "GO:0006567:L-threonine catabolic process:P"], "name": "2am3keto_CoA_ligase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011283": {"description": "Acetoacetyl-CoA reductase", "go_ids": ["GO:0005737", "GO:0018454", "GO:0042619"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0018454:acetoacetyl-CoA reductase activity:F", "GO:0042619:poly-hydroxybutyrate biosynthetic process:P"], "name": "Acetoacetyl-CoA_reductase", "pathway_ids": ["PWY-7216", "PWY-5676", "PWY-7948", "PWY-5741", "PWY-8425"], "pathways": ["PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-5676:t:acetyl-CoA fermentation to butanoate", "PWY-7948:t:4-oxopentanoate 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"PWY-7395", "PWY-7077"], "pathways": ["PWY-8324:t:D-tagatose degradation", "PWY-7395:t:D-galactosamine and N-acetyl-D-galactosamine degradation", "PWY-7077:t:N-acetyl-D-galactosamine degradation"], "type": "Family"}, "IPR011289": {"description": "Fructose-1,6-bisphosphate aldolase, class 2", "go_ids": ["GO:0004332", "GO:0006096", "GO:0008270", "GO:0030388"], "go_terms": ["GO:0004332:fructose-bisphosphate aldolase activity:F", "GO:0006096:glycolytic process:P", "GO:0008270:zinc ion binding:F", "GO:0030388:fructose 1,6-bisphosphate metabolic process:P"], "name": "Fruc_bis_ald_class-2", "pathway_ids": ["PWY-1042", "PWY-8178", "PWY-8404", "PWY-6142", "PWY-1861", "PWY-7385", "PWY-5484"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)"], "type": "Family"}, "IPR011290": {"description": "Nitrogenase iron-iron protein, alpha chain", "go_ids": ["GO:0009399", "GO:0016163", "GO:0051536"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Nase_Fe-Fe_asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011291": {"description": "Beta-Ala-Xaa dipeptidase", "go_ids": [], "go_terms": [], "name": "PepV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011292": {"description": "Na(+)-translocating NADH-quinone reductase subunit D", "go_ids": ["GO:0016655"], "go_terms": ["GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F"], "name": "NqrD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011293": {"description": "Ion-translocating oxidoreductase complex, 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"GO:0016020:membrane:C"], "name": "PTS_IIBC_treh", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011297": {"description": "Phosphotransferase system, beta-glucoside-specific IIABC component", "go_ids": ["GO:0008982", "GO:0009401", "GO:0005886"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0005886:plasma membrane:C"], "name": "PTS_IIABC_b_glu", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR011298": {"description": "FeS A-type assembly protein SufA, proteobacteria", "go_ids": ["GO:0016226", "GO:0051536"], "go_terms": ["GO:0016226:iron-sulfur cluster assembly:P", "GO:0051536:iron-sulfur cluster binding:F"], "name": "SufA_proteobacteria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011299": {"description": "PTS system glucose-specific IIBC component", "go_ids": ["GO:1904659", "GO:0016020", "GO:0055056"], "go_terms": ["GO:1904659:D-glucose transmembrane transport:P", "GO:0016020:membrane:C", "GO:0055056:D-glucose transmembrane transporter activity:F"], "name": "PTS_IIBC_glc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011300": {"description": "Phosphotransferase system, IIBC component", "go_ids": [], "go_terms": [], "name": "PTS_IIBC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011301": {"description": "PTS system, maltose/glucose-specific IIBC component", "go_ids": ["GO:0009401", "GO:0008982"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F"], "name": "PTS_Mal/Glc-sp_IIBC_component", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011302": {"description": "FeS A-type assembly protein IscA, proteobacteria", "go_ids": ["GO:0051536", "GO:0016226"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F", "GO:0016226:iron-sulfur cluster assembly:P"], "name": "IscA_proteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011303": {"description": "Ion-translocating oxidoreductase complex subunit RnfD, bacterial", "go_ids": ["GO:0016020", "GO:0022900"], "go_terms": ["GO:0016020:membrane:C", "GO:0022900:electron transport chain:P"], "name": "RnfD_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011304": {"description": "L-lactate dehydrogenase", "go_ids": ["GO:0004459", "GO:0005737"], "go_terms": ["GO:0004459:L-lactate dehydrogenase (NAD+) activity:F", "GO:0005737:cytoplasm:C"], "name": "L-lactate_DH", "pathway_ids": ["PWY-5031", "PWY-6901", "PWY-5481", "PWY-8086", "R-MMU-70268", "R-DME-70268", "R-CEL-70268", "R-DRE-9861718", "R-RNO-70268", "R-DRE-70268", "R-MMU-9861718", "R-GGA-373920", "R-BTA-70268", "R-GGA-70268", "R-BTA-9861718", "R-RNO-9861718", "R-DME-9861718", "R-HSA-70268", "R-HSA-9861718"], "pathways": ["PWY-5031:t:L-histidine degradation V", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-5481:t:pyruvate fermentation to (S)-lactate", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "R-MMU-70268:r:Pyruvate metabolism", "R-DME-70268:r:Pyruvate metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-RNO-70268:r:Pyruvate metabolism", "R-DRE-70268:r:Pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-GGA-373920:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-GGA-70268:r:Pyruvate metabolism", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism"], "type": "Family"}, "IPR011305": {"description": "Energy-converting hydrogenase subunit EhaL family member MJ0518", "go_ids": [], "go_terms": [], "name": "MJ0518", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011306": {"description": "Probable [NiFe]-hydrogenase-type-3 Eha complex membrane subunit A", "go_ids": [], "go_terms": [], "name": "Prd_NiFe_hyd_3_EhaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011307": {"description": "Tetrahydromethanopterin S-methyltransferase, subunit F", "go_ids": ["GO:0015948", "GO:0016020", "GO:0030269"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0016020:membrane:C", "GO:0030269:tetrahydromethanopterin S-methyltransferase activity:F"], "name": "MeTrfase_F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011308": {"description": "Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaD", "go_ids": [], "go_terms": [], "name": "Prd_NiFe_hyd_3_EhaD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011310": {"description": "Lipopolysaccharide core heptose(II)-phosphate phosphatase", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "LipoPS_heptP_Pase", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR011311": {"description": "Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaG", "go_ids": [], "go_terms": [], "name": "Prd_NiFe_hyd_3_EhaG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011312": {"description": "Methanogenesis marker 7 protein", "go_ids": [], "go_terms": [], "name": "Menthan_mark_7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011313": {"description": "Predicted 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[], "pathways": [], "type": "Family"}, "IPR011318": {"description": "Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaI", "go_ids": [], "go_terms": [], "name": "Prd_NiFe_hyd_3_EhaI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011319": {"description": "Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaK", "go_ids": [], "go_terms": [], "name": "Prd_NiFe_hyd_3_EhaK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011320": {"description": "Ribonuclease H1, N-terminal", "go_ids": [], "go_terms": [], "name": "RNase_H1_N", "pathway_ids": ["R-RNO-9013404", "R-RNO-9013408", "R-HSA-2995383", "R-HSA-9013408", "R-RNO-2995383", "R-HSA-9013404", "R-HSA-9913635"], "pathways": ["R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", 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toxin, alpha subunit", "go_ids": [], "go_terms": [], "name": "SMK_a", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011329": {"description": "Killer toxin Kp4/SMK", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Killer_tox_Kp4/SMK", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR011330": {"description": "Glycoside hydrolase/deacetylase, beta/alpha-barrel", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "Glyco_hydro/deAcase_b/a-brl", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-MMU-8853383", "R-BTA-8853383", "R-DME-381426", "R-HSA-6811438", "R-DME-8957275", "R-HSA-975578", "R-HSA-9694548", "R-BTA-6798695", "R-BTA-4085001", "R-DDI-8853383", "R-RNO-8853383", "R-DME-975578", "R-HSA-8853383", "R-MMU-4085001", "R-RNO-4085001", "R-SPO-8853383", "R-MMU-6798695", "R-RNO-975578", "R-HSA-4085001", "R-MMU-975578", "R-SCE-8853383"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-BTA-8853383:r:Lysosomal oligosaccharide catabolism", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-9694548:r:Maturation of spike protein", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-4085001:r:Sialic acid metabolism", "R-DDI-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-4085001:r:Sialic acid metabolism", "R-RNO-4085001:r:Sialic acid metabolism", 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"R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR011332": {"description": "Zinc-binding ribosomal protein", "go_ids": ["GO:0006412"], "go_terms": ["GO:0006412:translation:P"], "name": "Ribosomal_zn-bd", "pathway_ids": ["R-DDI-936440", "R-GGA-901032", "R-DME-2173795", "R-HSA-6807004", "R-HSA-8866427", "R-MMU-5656121", "R-RNO-187577", 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"R-BTA-1169091", "R-BTA-2500257", "R-DME-9664873", "R-DME-5676590", "R-HSA-9013507", "R-HSA-2691232", "R-GGA-433871", "R-DDI-174084", "R-HSA-5607761", "R-RNO-5656121", "R-MMU-9932298", "R-RNO-5696395", "R-RNO-975163", "R-BTA-72702", "R-GGA-5654726", "R-DME-450302", "R-GGA-9954716", "R-RNO-209543", "R-HSA-8866654", "R-MMU-4641258", "R-HSA-909733", "R-SSC-975957", "R-GGA-6804760", "R-RNO-936440", "R-RNO-9954709", "R-BTA-4641257", "R-BTA-6782210", "R-DME-5389840", "R-BTA-205043", "R-MMU-9766229", "R-RNO-69481", "R-DDI-187577", "R-HSA-174154", "R-GGA-187577", "R-HSA-9833109", "R-RNO-1234176", "R-RNO-9932298", "R-GGA-5685942", "R-HSA-174178", "R-HSA-9604323", "R-BTA-975957", "R-HSA-8951664", "R-MMU-6804756", "R-DDI-6782210", "R-DME-937072", "R-HSA-69231", "R-MMU-110314", "R-MMU-5689880", "R-HSA-5368286", "R-DDI-9929491", "R-GGA-68949", "R-BTA-5696397", "R-RNO-8854050", "R-HSA-937041", "R-MMU-5696394", "R-RNO-450408", "R-GGA-209560", "R-HSA-211733", "R-HSA-9956593", "R-HSA-9708530", "R-DME-4641257", "R-RNO-975144", "R-GGA-8948751", "R-MMU-3134975", "R-RNO-9705462", "R-RNO-936964", "R-MMU-1234176", "R-RNO-6804760", "R-DRE-1799339", "R-GGA-110312", "R-GGA-909733", "R-MMU-5357905", "R-PFA-1799339", "R-BTA-69017", "R-GGA-9931269", "R-BTA-349425", "R-GGA-5689877", "R-DDI-382556", "R-CFA-975957", "R-MMU-187577", "R-BTA-9931295", "R-RNO-937072", "R-BTA-5676590", "R-MMU-5693565", "R-GGA-6807004", "R-DME-174084", "R-RNO-2565942", "R-DME-9929491", "R-RNO-8856828", "R-BTA-209560", "R-SCE-72689", "R-BTA-3134975", "R-RNO-937041", "R-BTA-5655862", "R-CEL-5389840", "R-DDI-917937", "R-DDI-69231", "R-HSA-5654726", "R-RNO-9755511", "R-DME-5696395", "R-DME-174184", "R-RNO-5685942", "R-MMU-6783310", "R-GGA-5689880", "R-RNO-68867", "R-DME-9932298", "R-RNO-9762114", "R-BTA-9954709", "R-SSC-6791226", "R-DDI-156827", "R-HSA-937039", "R-HSA-5358346", "R-BTA-174113", "R-RNO-9020702", "R-MMU-4641263", "R-GGA-450408", "R-HSA-9932298", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-8951664", "R-GGA-9932298", "R-MMU-9954716", "R-MMU-445989", "R-RNO-174154", "R-CEL-72706", "R-GGA-5357956", "R-DME-9762114", "R-HSA-69481", "R-GGA-9824878", "R-SPO-72706", "R-SCE-975956", "R-BTA-9648002", "R-BTA-5358346", "R-RNO-8939236", "R-RNO-2173791", "R-HSA-180585", "R-RNO-168638", "R-RNO-2467813", "R-DME-5607764", "R-HSA-9954714", "R-DDI-8866652", "R-RNO-2559585", "R-DME-8941858", "R-GGA-351465", "R-MMU-9937383", "R-BTA-382556", "R-MMU-9648002", "R-RNO-2500257", "R-CEL-72702", "R-BTA-5663220", "R-MMU-72649", "R-HSA-192823", "R-GGA-174154", "R-HSA-9636383", "R-GGA-353303", "R-GGA-8939236", "R-DME-216167", "R-GGA-2467813", "R-DME-975144", "R-DDI-9861718", "R-MMU-2500257", "R-GGA-6804757", "R-HSA-69601", "R-BTA-9861718", "R-HSA-983168", "R-MMU-9033241", "R-BTA-5689603", "R-BTA-8856825", "R-SCE-72649", "R-RNO-8941858", "R-RNO-1169091", "R-SPO-9837999", "R-DRE-72689", "R-HSA-9692916", "R-HSA-917937", "R-GGA-5610780", "R-HSA-202424", "R-SCE-72706", "R-MMU-9645460", "R-HSA-156827", "R-RNO-450321", "R-RNO-5654727", "R-GGA-5684264", "R-DME-450321", "R-BTA-9010553", "R-HSA-2173795", "R-HSA-9762114", "R-MMU-975956", "R-SCE-156827", "R-HSA-9770562", "R-HSA-4641263", "R-GGA-9020702", "R-DME-8939236", "R-HSA-1358803", "R-RNO-174113", "R-DDI-5675221", "R-RNO-9824878", "R-BTA-9645460", "R-DME-9954714", "R-DDI-9664873", "R-DDI-1799339", "R-BTA-110320", "R-HSA-2173788", "R-BTA-5357905", "R-DME-975957", "R-DME-5689880", "R-MMU-1253288", "R-RNO-201681", "R-RNO-110312", "R-GGA-8866654", "R-HSA-5689896", "R-HSA-9828211", "R-HSA-8856828", "R-BTA-202424", "R-MMU-110320", "R-MMU-5689901", "R-MMU-2122948", "R-DME-912631", "R-MMU-5205685", "R-MMU-2565942", "R-HSA-936964", "R-MMU-5696395", "R-DME-8939902", "R-HSA-6804757", "R-GGA-6782135", "R-DME-4608870", "R-GGA-8856828", "R-RNO-6782210", "R-SSC-72706", "R-MMU-141444", "R-HSA-209560", "R-RNO-5205685", "R-DDI-6781823", "R-HSA-9735869", "R-HSA-4641258", "R-RNO-6791226", "R-BTA-4641258", "R-HSA-4608870", "R-RNO-3134975", "R-BTA-937039", "R-MMU-1799339", "R-SPO-72702", "R-MMU-5610780", "R-RNO-1295596", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-SSC-156827", "R-HSA-5362768", "R-DDI-9954709", "R-GGA-174113", "R-RNO-8852276", "R-BTA-6807004", "R-BTA-174178", "R-BTA-3769402", "R-HSA-2500257", "R-HSA-2173791", "R-SSC-975956", "R-GGA-434001", "R-RNO-110320", "R-HSA-9754678", "R-BTA-8854050", "R-HSA-9683683", "R-GGA-5696395", "R-CFA-975956", "R-BTA-5607764", "R-DDI-450408", "R-HSA-69541", "R-MMU-5419276", "R-GGA-75815", "R-GGA-937042", "R-HSA-5689880", "R-GGA-110314", "R-DME-5654732", "R-BTA-450321", "R-DME-1295596", "R-GGA-5632684", "R-HSA-1234176", "R-DME-2559582", "R-MMU-68867", "R-HSA-182971", "R-DME-174048", "R-RNO-5654732", "R-BTA-182971", "R-BTA-6782135", "R-DME-209461", "R-HSA-141444", "R-BTA-2173788", "R-HSA-6804760", "R-HSA-72702", "R-GGA-937072", "R-GGA-9013507", "R-BTA-917937", "R-HSA-5696394", "R-DME-69601", "R-HSA-2644606", "R-MMU-5675221", "R-DME-69017", "R-DME-983168", "R-GGA-9758274", "R-RNO-5676590", "R-HSA-2467813", "R-HSA-6781827", "R-HSA-168928", "R-HSA-937042", "R-BTA-195253", "R-DDI-6791226", "R-RNO-69601", "R-HSA-9861718", "R-MMU-9664873", "R-MMU-917937", "R-MMU-9762114", "R-BTA-5696400", "R-GGA-349425", "R-MMU-205043", "R-MMU-195253", "R-SCE-72695", "R-MMU-72695", "R-BTA-8856828", "R-MMU-382556", "R-BTA-9705462", "R-GGA-6783310", "R-DME-209360", "R-DME-5357905", "R-RNO-75815", "R-DME-72689", "R-RNO-72702", "R-MMU-1169091", "R-HSA-72649", "R-DME-8854050", "R-RNO-9770562", "R-GGA-1169091", "R-HSA-5696400", "R-DME-5419276", "R-RNO-9954714", "R-PFA-9954714", "R-DDI-8854050", "R-BTA-69231", "R-MMU-5607764", "R-DME-69231", "R-BTA-5668541", "R-CFA-1799339", "R-DME-5656121", "R-GGA-5358346", "R-HSA-5676590", "R-DRE-9954709", "R-DME-9954716", "R-BTA-72689", "R-DDI-9020702", "R-GGA-5687128", "R-HSA-3322077", "R-BTA-9837999", "R-GGA-5693565", "R-BTA-72695", "R-HSA-174490", "R-MMU-975163", "R-RNO-5607761", "R-GGA-4641257", "R-HSA-1799339", "R-BTA-937042", "R-GGA-8849469", "R-DME-5689877", "R-HSA-110312", "R-DME-2173791", "R-CEL-156827", "R-DME-3769402", "R-GGA-8948747", "R-HSA-1169091", "R-DME-975163", "R-HSA-9033241", "R-MMU-450408", "R-DME-110314", "R-HSA-9020702", "R-RNO-8948751", "R-HSA-168638", "R-MMU-9020702", "R-SPO-975957", "R-MMU-8866652", "R-GGA-1358803", "R-MMU-75815", "R-HSA-168927", "R-HSA-8854050", "R-RNO-5656169", "R-BTA-5607761", "R-DDI-9033241", "R-DME-6782135", "R-MMU-174084", "R-SCE-72702", "R-SPO-9954709", "R-GGA-8866652", "R-HSA-9929491", "R-HSA-5654727", "R-BTA-6791226", "R-SSC-9954714", "R-MMU-2559582", "R-HSA-6783310", "R-DME-5675221", "R-DDI-937042", "R-SSC-1799339", "R-HSA-1295596", "R-RNO-8951664", "R-GGA-195253", "R-DME-1234176", "R-HSA-1236974", "R-HSA-9648002", "R-RNO-5358346", "R-CEL-72689", "R-RNO-2173796", "R-HSA-9954716", "R-HSA-68949", "R-HSA-9705671", "R-MMU-72689", "R-BTA-68949", "R-MMU-179409", "R-HSA-2672351", "R-RNO-1253288", "R-RNO-69541", "R-DME-8866652", "R-MMU-6781823", "R-GGA-8941858", "R-HSA-68877", "R-GGA-9954714", "R-DDI-2467813", "R-RNO-349425", "R-MMU-5693607", "R-GGA-975163", "R-MMU-912631", "R-BTA-9954716", "R-GGA-5656121", "R-MMU-975957", "R-MMU-9706369", "R-GGA-5696394", "R-DME-901032", "R-RNO-69231", "R-HSA-8939902", "R-MMU-5654726", "R-DDI-174184", "R-DME-5696400", "R-DME-174178", "R-RNO-9646399", "R-BTA-5419276", "R-GGA-1799339", "R-RNO-6783310", "R-MMU-182971", "R-HSA-5696397", "R-GGA-5654727", "R-GGA-1234176", "R-RNO-1799339", "R-HSA-5655862", "R-RNO-72695", "R-MMU-9929491", "R-BTA-9932298", "R-GGA-6781823", "R-GGA-72706", "R-GGA-3769402", "R-HSA-68867", "R-DME-174154", "R-GGA-110320", "R-GGA-2173796", "R-BTA-450408", "R-DDI-72695", "R-CEL-1799339", "R-HSA-8941858", "R-GGA-450321", "R-BTA-9937383", "R-DME-9755511", "R-RNO-975956", "R-DME-5610785", "R-RNO-174084", "R-HSA-5689603", "R-HSA-5654733", "R-DME-2122948", "R-BTA-8951664", "R-MMU-6782135", "R-MMU-8856825", "R-HSA-349425", "R-BTA-8941858", "R-DME-4641258", "R-MMU-9010553", "R-HSA-936440", "R-HSA-2559582", "R-HSA-1169408", "R-BTA-2467813", "R-DME-917729", "R-DME-975956", "R-BTA-5689896", "R-SPO-72649", "R-HSA-382556", "R-HSA-8852276", "R-HSA-156902", "R-HSA-6782135", "R-HSA-9645460", "R-DDI-983168", "R-HSA-9929356", "R-DME-5205685", "R-MMU-983168", "R-GGA-182971", "R-SPO-6791226", "R-RNO-9861718", "R-HSA-5675221", "R-GGA-5689901", "R-MMU-8856828", "R-HSA-9646399", "R-PFA-72689", "R-BTA-9755511", "R-SPO-9954714", "R-GGA-5654733", "R-MMU-68877", "R-GGA-5675221", "R-DME-8849469", "R-HSA-8863795", "R-SCE-6791226", "R-CFA-72706", "R-DDI-5689901", "R-DME-5655862", "R-BTA-69481", "R-HSA-450302", "R-BTA-110314", "R-MMU-909733", "R-GGA-1227892", "R-GGA-9766229", "R-HSA-9931295", "R-DRE-9954714", "R-HSA-205043", "R-HSA-9758274", "R-MMU-8948747", "R-HSA-72706", "R-MMU-201681", "R-BTA-5693565", "R-RNO-5663220", "R-RNO-6804757", "R-HSA-6804756", "R-CEL-9937383", "R-DDI-4641258", "R-GGA-179409", "R-HSA-180534", "R-HSA-9680350", "R-DDI-72689", "R-GGA-9646399", "R-RNO-5632684", "R-DDI-5696395", "R-MMU-450302", "R-RNO-174178", "R-DME-2565942", "R-MMU-5357956", "R-MMU-174178", "R-DDI-1358803", "R-BTA-936440", "R-BTA-209543", "R-RNO-9645460", "R-BTA-445989", "R-DME-1799339", "R-HSA-6782210", "R-GGA-1227882", "R-DDI-917729", "R-GGA-936964", "R-CFA-72689", "R-HSA-195253", "R-HSA-9706369", "R-MMU-936964", "R-GGA-69601", "R-BTA-187577", "R-GGA-8856825", "R-HSA-5658442", "R-BTA-8852276", "R-RNO-532668", "R-HSA-1253288", "R-HSA-3134975", "R-HSA-9613829", "R-DDI-5689877", "R-MMU-5389840", "R-RNO-2122948", "R-HSA-110314", "R-HSA-5689901", "R-HSA-187577", "R-HSA-901032", "R-DME-382556", "R-HSA-209543", "R-GGA-4641258", "R-DME-5610780", "R-DDI-9770562", "R-DME-195253", "R-MMU-69601", "R-RNO-2672351", "R-SCE-975957", "R-DDI-975163", "R-BTA-5654732", "R-PFA-72706", "R-DME-110312", "R-DME-5607761", "R-HSA-1236382", "R-MMU-8854050", "R-HSA-5656169", "R-HSA-937072", "R-HSA-5607764", "R-MMU-9648025", "R-MMU-1358803", "R-RNO-8948747", "R-MMU-3769402", "R-DME-9033241", "R-BTA-2173791", "R-RNO-6782135", "R-DME-9837999", "R-DRE-975957", "R-SSC-9954709", "R-DME-538864", "R-GGA-2173791", "R-GGA-975957", "R-GGA-174184", "R-HSA-5687128", "R-BTA-450302", "R-RNO-909733", "R-RNO-5357956", "R-DDI-72706", "R-HSA-110320", "R-BTA-975163"], "pathways": ["R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-GGA-901032:r:ER Quality Control Compartment (ERQC)", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-GGA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-9020702:r:Interleukin-1 signaling", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5689877:r:Josephin domain DUBs", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-9706369:r:Negative regulation of FLT3", "R-DDI-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-GGA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-4641257:r:Degradation of AXIN", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-GGA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-977225:r:Amyloid fiber formation", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-BTA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-2672351:r:Stimuli-sensing channels", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-5689603:r:UCH proteinases", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-GGA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-GGA-2672351:r:Stimuli-sensing channels", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-182971:r:EGFR downregulation", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-5689603:r:UCH proteinases", "R-GGA-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-2467813:r:Separation of Sister Chromatids", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-5689901:r:Metalloprotease DUBs", "R-RNO-4641258:r:Degradation of DVL", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-2408557:r:Selenocysteine synthesis", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-GGA-209543:r:p75NTR recruits signalling complexes", "R-GGA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-182971:r:EGFR downregulation", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-4641257:r:Degradation of AXIN", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-5689603:r:UCH proteinases", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689877:r:Josephin domain DUBs", "R-GGA-9033241:r:Peroxisomal protein import", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-9664873:r:Pexophagy", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-9664873:r:Pexophagy", "R-DDI-9646399:r:Aggrephagy", "R-MMU-69541:r:Stabilization of p53", "R-DDI-5632684:r:Hedgehog 'on' state", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9694493:r:Maturation of protein E", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-912631:r:Regulation of signaling by CBL", "R-DME-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-GGA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-DDI-9758274:r:Regulation of NF-kappa B signaling", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-CFA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-9766229:r:Degradation of CDH1", "R-GGA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-GGA-573298:r:NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-GGA-69541:r:Stabilization of p53", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5689603:r:UCH proteinases", "R-GGA-353299:r:RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-9664873:r:Pexophagy", "R-GGA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-PFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-432524:r:Degradation of PER", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-5689901:r:Metalloprotease DUBs", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-GGA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-PFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-GGA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-GGA-1295596:r:Spry regulation of FGF signaling", "R-GGA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-912631:r:Regulation of signaling by CBL", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5419276:r:Mitochondrial translation termination", "R-GGA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-5419276:r:Mitochondrial translation termination", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-9033241:r:Peroxisomal protein import", "R-GGA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-GGA-382556:r:ABC-family proteins mediated transport", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-DME-8948747:r:Regulation of PTEN localization", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-901032:r:ER Quality Control Compartment (ERQC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-GGA-68867:r:Assembly of the pre-replicative complex", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-8948747:r:Regulation of PTEN localization", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-BTA-9646399:r:Aggrephagy", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-8948747:r:Regulation of PTEN localization", "R-MMU-110312:r:Translesion synthesis by REV1", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-GGA-8939902:r:Regulation of RUNX2 expression and activity", "R-GGA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-5689603:r:UCH proteinases", "R-MMU-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-GGA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-GGA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-68949:r:Orc1 removal from chromatin", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-69481:r:G2/M Checkpoints", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-5689877:r:Josephin domain DUBs", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-9648002:r:RAS processing", "R-RNO-72649:r:Translation initiation complex formation", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9646399:r:Aggrephagy", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CEL-72649:r:Translation initiation complex formation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9664873:r:Pexophagy", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-GGA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-68949:r:Orc1 removal from chromatin", "R-GGA-8951664:r:Neddylation", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-GGA-9770562:r:mRNA Polyadenylation", "R-HSA-9615710:r:Late endosomal microautophagy", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DME-917937:r:Iron uptake and transport", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-68877:r:Mitotic Prometaphase", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-PFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-9646399:r:Aggrephagy", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-MMU-6807004:r:Negative regulation of MET activity", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-GGA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-GGA-5689896:r:Ovarian tumor domain proteases", "R-DDI-5358346:r:Hedgehog ligand biogenesis", "R-DME-209560:r:NF-kB is activated and signals survival", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-GGA-69231:r:Cyclin D associated events in G1", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-1227888:r:Negative Regulation of MDA5 signaling", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-5675482:r:Regulation of necroptotic cell death", "R-DME-110320:r:Translesion Synthesis by POLH", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-PFA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-BTA-110312:r:Translesion synthesis by REV1", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-9648002:r:RAS processing", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-8948747:r:Regulation of PTEN localization", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-5689877:r:Josephin domain DUBs", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-GGA-201681:r:TCF dependent signaling in response to WNT", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-912631:r:Regulation of signaling by CBL", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-PFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-9664873:r:Pexophagy", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-GGA-433871:r:TRAF6 mediated induction of proinflammatory cytokines", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-GGA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-4641257:r:Degradation of AXIN", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5389840:r:Mitochondrial translation elongation", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-8951664:r:Neddylation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-68949:r:Orc1 removal from chromatin", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-209560:r:NF-kB is activated and signals survival", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-DME-4641257:r:Degradation of AXIN", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-PFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-GGA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-5689877:r:Josephin domain DUBs", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-CFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-6807004:r:Negative regulation of MET activity", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-GGA-5689880:r:Ub-specific processing proteases", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-BTA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-GGA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-5357956:r:TNFR1-induced NF-kappa-B 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"R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-GGA-6782135:r:Dual incision in TC-NER", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-3134975:r:Regulation of innate 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mRNA", "R-HSA-69541:r:Stabilization of p53", "R-MMU-5419276:r:Mitochondrial translation termination", "R-GGA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-GGA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-GGA-5632684:r:Hedgehog 'on' state", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-182971:r:EGFR downregulation", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-182971:r:EGFR downregulation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-917937:r:Iron uptake and transport", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen 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"R-DME-5689877:r:Josephin domain DUBs", "R-HSA-110312:r:Translesion synthesis by REV1", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-GGA-8948747:r:Regulation of PTEN localization", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex 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[], "type": "Family"}, "IPR011381": {"description": "Histone-lysine N-methyltransferase SUV39H1/2-like", "go_ids": ["GO:0005634", "GO:0046974"], "go_terms": ["GO:0005634:nucleus:C", "GO:0046974:histone H3K9 methyltransferase activity:F"], "name": "H3-K9_MeTrfase_SUV39H1/2-like", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-3214841", "R-DRE-3214841", "R-MMU-3214841", "R-DME-427359", "R-HSA-427359"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression"], "type": "Family"}, "IPR011383": {"description": "N-lysine methyltransferase SETD6", "go_ids": ["GO:0016279", "GO:0018026"], "go_terms": ["GO:0016279:protein-lysine N-methyltransferase activity:F", "GO:0018026:peptidyl-lysine monomethylation:P"], "name": "N-lys_methylase_SETD6", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-RNO-3214841", "R-MMU-3214841", "R-HSA-3214841"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines"], "type": "Family"}, "IPR011385": {"description": "Putative site-specific recombinase Gcr", "go_ids": [], "go_terms": [], "name": "Site-sp_rcmbase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011386": {"description": "Putative ATP-NAD kinase", "go_ids": [], "go_terms": [], "name": "Put_ATP-NAD_kin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011387": {"description": "Translation initiation factor 2A", "go_ids": ["GO:0003743", "GO:0006413"], "go_terms": ["GO:0003743:translation initiation factor activity:F", "GO:0006413:translational initiation:P"], "name": "TIF2A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011388": {"description": "Sphingolipid delta4-desaturase", "go_ids": ["GO:0042284", "GO:0016020", "GO:0030148"], "go_terms": ["GO:0042284:sphingolipid delta-4 desaturase activity:F", "GO:0016020:membrane:C", "GO:0030148:sphingolipid biosynthetic process:P"], "name": "DES1/DES2", "pathway_ids": ["PWY-5129", "R-HSA-6798695", "R-SPO-6798695", "R-BTA-1660661", "R-XTR-1660661", "R-DME-6798695", "R-CEL-6798695", "R-DME-1660661", "R-RNO-1660661", "R-MMU-6798695", "R-BTA-6798695", "R-CEL-1660661", "R-HSA-1660661", "R-XTR-6798695", "R-GGA-433584", "R-GGA-6798695", "R-RNO-6798695", "R-GGA-1660661", "R-MMU-1660661"], "pathways": ["PWY-5129:t:sphingolipid biosynthesis (plants)", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-XTR-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-XTR-6798695:r:Neutrophil degranulation", "R-GGA-433584:r:Sphingolipid metabolism", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-GGA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR011390": {"description": "Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25", "go_ids": ["GO:0001558", "GO:0005520", "GO:0005576"], "go_terms": ["GO:0001558:regulation of cell growth:P", "GO:0005520:insulin-like growth factor binding:F", "GO:0005576:extracellular region:C"], "name": "IGFBP_rP_mac25", "pathway_ids": ["R-MMU-381426", "R-HSA-8957275", "R-HSA-2559582", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR011391": {"description": "Acetoin catabolism kinase AcoX", "go_ids": [], "go_terms": [], "name": "AcoX_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011392": {"description": "Tellurite resistance, TerY", "go_ids": [], "go_terms": [], "name": "Tellurite-R_TerY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011395": {"description": "Alpha glucuronidase", "go_ids": ["GO:0005576", "GO:0045493", "GO:0046559"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0045493:xylan catabolic process:P", "GO:0046559:alpha-glucuronidase activity:F"], "name": "Glyco_hydro_67_aGlcAse", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011396": {"description": "Phosphorothioated DNA-binding restriction endonuclease", "go_ids": [], "go_terms": [], "name": "PT_DNA_restrict", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011397": {"description": "Intramembrane metalloprotease YhfC", "go_ids": [], "go_terms": [], "name": "YhfC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011399": {"description": "Nitrous oxide reductase expression regulator NosR", "go_ids": ["GO:0003677", "GO:0016020", "GO:0045893"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0016020:membrane:C", "GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "NosR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011400": {"description": "Eukaryotic translation initiation factor 3 subunit B", "go_ids": ["GO:0003723", "GO:0003743", "GO:0006413", "GO:0005852", "GO:0031369"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003743:translation initiation factor activity:F", "GO:0006413:translational initiation:P", "GO:0005852:eukaryotic translation initiation factor 3 complex:C", "GO:0031369:translation initiation factor binding:F"], "name": "EIF3B", "pathway_ids": ["R-CEL-72689", "R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-72695", "R-BTA-72689", "R-RNO-72695", "R-MMU-72706", "R-SPO-72689", "R-BTA-72695", "R-SCE-72695", "R-SCE-72702", "R-MMU-72695", "R-SCE-156827", "R-BTA-156827", "R-DME-72695", "R-MMU-72702", "R-RNO-156827", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-BTA-72702", "R-DME-72689", "R-HSA-72706", "R-RNO-72702", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-CEL-156827", "R-RNO-72649", "R-SCE-72649", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-BTA-72649", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": ["R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Family"}, "IPR011401": {"description": "Phosphoesterase, YvnB", "go_ids": [], "go_terms": [], "name": "Pesterase_YvnB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011402": {"description": "Phospholipase D, plant", "go_ids": ["GO:0004630", "GO:0005509", "GO:0016020", "GO:0046470"], "go_terms": ["GO:0004630:D-type glycerophospholipase activity:F", "GO:0005509:calcium ion binding:F", "GO:0016020:membrane:C", "GO:0046470:phosphatidylcholine metabolic process:P"], "name": "PLipase_D_pln", "pathway_ids": ["PWY-3561", "PWY-7039"], "pathways": ["PWY-3561:t:choline biosynthesis III", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule"], "type": "Family"}, "IPR011403": {"description": "Pyrophosphate-dependent phosphofructokinase TM0289 type", "go_ids": ["GO:0006096", "GO:0047334"], "go_terms": ["GO:0006096:glycolytic process:P", "GO:0047334:diphosphate-fructose-6-phosphate 1-phosphotransferase activity:F"], "name": "PPi-PFK_TM0289", "pathway_ids": ["PWY-1042", "PWY-8178"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II"], "type": "Family"}, "IPR011405": {"description": "Pyrophosphate-dependent phosphofructokinase SMc01852 type", "go_ids": ["GO:0006096", "GO:0047334"], "go_terms": ["GO:0006096:glycolytic process:P", "GO:0047334:diphosphate-fructose-6-phosphate 1-phosphotransferase activity:F"], "name": "PPi-PFK_SMc01852", "pathway_ids": ["PWY-1042", "PWY-8178"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II"], "type": "Family"}, "IPR011406": {"description": "Globin, trematode", "go_ids": ["GO:0005506", "GO:0015671", "GO:0019825", "GO:0020037"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0015671:oxygen transport:P", "GO:0019825:oxygen binding:F", "GO:0020037:heme binding:F"], "name": "Globin_trematode", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011407": {"description": "10-formyltetrahydrofolate dehydrogenase", "go_ids": ["GO:0005737", "GO:0006730", "GO:0009258", "GO:0016155"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006730:one-carbon metabolic process:P", "GO:0009258:10-formyltetrahydrofolate catabolic process:P", "GO:0016155:formyltetrahydrofolate dehydrogenase activity:F"], "name": "10_FTHF_DH", "pathway_ids": ["R-RNO-196757", "R-HSA-196757", "R-XTR-196757", "R-MMU-196757"], "pathways": ["R-RNO-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-XTR-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines"], "type": "Family"}, "IPR011408": {"description": "Aldehyde dehydrogenase", "go_ids": [], "go_terms": [], "name": "Aldehyde_DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011410": {"description": "Nucleoside diphosphate kinase 7", "go_ids": ["GO:0004550", "GO:0005524"], "go_terms": ["GO:0004550:nucleoside diphosphate kinase activity:F", "GO:0005524:ATP binding:F"], "name": "NDPK7", "pathway_ids": ["R-BTA-380320", "R-HSA-380320", "R-MMU-380270", "R-HSA-380270", "R-BTA-380270", "R-RNO-380270", "R-MMU-380320", "R-RNO-380320"], "pathways": ["R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes"], "type": "Family"}, "IPR011411": {"description": "NTP pyrophosphohydrolase MazG-related, YvdC", "go_ids": [], "go_terms": [], "name": "MazG-related_YvdC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011412": {"description": "Coronamic acid biosynthesis thioesterase CmaT", "go_ids": [], "go_terms": [], "name": "CmaT_thioesters", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011413": {"description": "Uncharacterised conserved protein UCP036540", "go_ids": [], "go_terms": [], "name": "UCP036540_AIR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011414": {"description": "Uncharacterized protein MJ0799", "go_ids": [], "go_terms": [], "name": "MJ0799", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011415": {"description": "Predicted bifunctional spore maturation protein, fused SpmA/SpmB", "go_ids": [], "go_terms": [], "name": "SpmA_SpmB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011416": {"description": "Predicted RNA-binding protein YdrC-type, Chlamydia", "go_ids": [], "go_terms": [], "name": "YdrC-type_chlamyd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011417": {"description": "AP180 N-terminal homology (ANTH) domain", "go_ids": ["GO:0005543"], "go_terms": ["GO:0005543:phospholipid binding:F"], "name": "ANTH_dom", "pathway_ids": ["R-DME-8856825", "R-CEL-8856828", "R-MMU-8856828", "R-RNO-8856825", "R-HSA-9700645", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-432722", "R-CEL-432722", "R-DME-432722", "R-HSA-9696264", "R-HSA-8856825", "R-RNO-9696264", "R-DME-8856828", "R-RNO-8856828", "R-MMU-9696264", "R-HSA-432722", "R-CEL-8856825", "R-HSA-9725370", "R-RNO-432722"], "pathways": ["R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-432722:r:Golgi 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"R-HSA-6802946", "R-CEL-5675221", "R-MMU-5673000", "R-CEL-5673000", "R-HSA-6802955", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-5673000:r:RAF activation", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-MMU-5673000:r:RAF activation", "R-CEL-5673000:r:RAF activation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR011425": {"description": "Mediator of RNA polymerase II transcription subunit 9", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Med9", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR011426": {"description": "CamS sex pheromone cAM373", "go_ids": [], "go_terms": [], "name": "CamS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011427": {"description": "Chlamydia polymorphic membrane, middle domain", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "Polymorphic_membr_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011428": {"description": "Spore coat protein X/V", "go_ids": ["GO:0030435", "GO:0031160"], "go_terms": ["GO:0030435:sporulation resulting in formation of a cellular spore:P", "GO:0031160:spore wall:C"], "name": "Spore_coat_X/V", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011429": {"description": "Cytochrome C, 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"R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR011489": {"description": "EMI domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "EMI_domain", "pathway_ids": ["R-MMU-2129379", "R-DRE-114608", "R-MMU-3000157", "R-HSA-2129379", "R-DRE-5173105", "R-DME-381426", "R-DME-8957275", "R-MMU-8948216", "R-HSA-977225", "R-DME-446107", "R-MMU-8957275", "R-HSA-5173105", "R-HSA-1650814", "R-HSA-114608", "R-MMU-8874081", "R-MMU-9913351", "R-DRE-2129379", "R-MMU-1650814", "R-MMU-381426", "R-HSA-8948216", "R-CEL-8957275", "R-CEL-381426", "R-MMU-1442490", "R-MMU-5173105", "R-HSA-1442490", "R-MMU-446107", "R-MMU-114608"], "pathways": ["R-MMU-2129379:r:Molecules associated with elastic fibres", "R-DRE-114608:r:Platelet degranulation", "R-MMU-3000157:r:Laminin interactions", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-DRE-5173105:r:O-linked glycosylation", "R-DME-381426:r:Regulation of Insulin-like Growth 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"R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1442490:r:Collagen degradation", "R-MMU-5173105:r:O-linked glycosylation", "R-HSA-1442490:r:Collagen degradation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR011491": {"description": "Flagellar hook protein FlgE, D2 domain", "go_ids": [], "go_terms": [], "name": "FlgE_D2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011492": {"description": "Non-structural protein NS3-like, DEAD-box helicase, flavivirus", "go_ids": ["GO:0005524", "GO:0004386"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0004386:helicase activity:F"], "name": "Flavi_DEAD", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-8854214", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-5621480", "R-HSA-9918481"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR011493": {"description": "GLUG", "go_ids": [], "go_terms": [], "name": "GLUG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011494": {"description": "Protein HIRA-like, C-terminal", "go_ids": ["GO:0006355", "GO:0006338"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0006338:chromatin remodeling:P"], "name": "HIRA-like_C", "pathway_ids": ["R-SCE-2559584", "R-HSA-2559584", "R-HSA-9821993", "R-MMU-2559584", "R-CEL-2559584"], "pathways": ["R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Domain"}, "IPR011495": {"description": "Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain", "go_ids": [], "go_terms": [], "name": "Sig_transdc_His_kin_sub2_dim/P", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011496": {"description": "Beta-N-acetylglucosaminidase, catalytic domain", "go_ids": [], "go_terms": [], "name": "O-GlcNAcase_cat", "pathway_ids": ["PWY-7437"], "pathways": ["PWY-7437:t:protein O-[N-acetyl]-glucosylation"], "type": "Domain"}, "IPR011498": {"description": "Kelch repeat type 2", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Kelch_2", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011499": {"description": "Lipid A biosynthesis, N-terminal", "go_ids": ["GO:0008915", "GO:0009245"], "go_terms": ["GO:0008915:lipid-A-disaccharide synthase activity:F", "GO:0009245:lipid A biosynthetic process:P"], "name": "Lipid_A_biosynth_N", "pathway_ids": ["PWY-8245", "PWY-8073", "PWY-8283"], "pathways": ["PWY-8245:t:lipid IVA biosynthesis (P. gingivalis)", "PWY-8073:t:lipid IVA biosynthesis (P. putida)", "PWY-8283:t:lipid IVA 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"R-DME-4615885", "R-HSA-4570464", "R-XTR-170822", "R-DRE-5663220", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-BTA-3301854", "R-DME-3371453", "R-MMU-141444", "R-SPO-159236", "R-BTA-3371453", "R-HSA-6784531", "R-MMU-3301854", "R-HSA-141444", "R-DME-159227", "R-BTA-4551638", "R-HSA-168325", "R-XTR-4085377", "R-BTA-4085377", "R-MMU-170822", "R-RNO-5663220", "R-DRE-3371453", "R-HSA-9648025", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-DME-9615933", "R-HSA-3301854", "R-MMU-159227", "R-RNO-4085377", "R-HSA-9615933", "R-BTA-9615933", "R-SPO-4570464", "R-DRE-159227", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-RNO-2467813", "R-MMU-3108214", "R-XTR-3108214", "R-HSA-159236", "R-BTA-9648025", "R-MMU-5663220", "R-RNO-141444", "R-BTA-191859", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-2467813", "R-HSA-3108214", "R-HSA-191859", "R-RNO-2500257", "R-HSA-9705671", "R-DRE-159231", "R-SPO-159227", "R-SPO-159231", 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"R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-191859:r:snRNP Assembly", "R-RNO-68877:r:Mitotic Prometaphase", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-BTA-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-XTR-68877:r:Mitotic Prometaphase", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-XTR-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion"], "type": "Family"}, "IPR011505": {"description": "Peptidase M26, C-terminal domain", "go_ids": ["GO:0004222", "GO:0005576", "GO:0005618", "GO:0008270"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0005576:extracellular region:C", "GO:0005618:cell wall:C", "GO:0008270:zinc ion binding:F"], "name": "Peptidase_M26_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011506": {"description": "Planctomycete extracellular", "go_ids": [], "go_terms": [], "name": "Planctomycete_extracellular", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011508": {"description": "RSD-2, N-terminal", "go_ids": [], "go_terms": [], "name": "RSD-2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011509": {"description": "RtxA toxin", "go_ids": [], "go_terms": [], "name": "RtxA_toxin", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011513": {"description": "Non-structural maintenance of chromosomes element 1", "go_ids": ["GO:0030915", "GO:0006281"], "go_terms": ["GO:0030915:Smc5-Smc6 complex:C", "GO:0006281:DNA repair:P"], "name": "Nse1", "pathway_ids": ["PWY-7511", "R-SCE-3108214", "R-DRE-3108214", "R-MMU-3108214", "R-SPO-3108214", "R-RNO-3108214", "R-HSA-3108214"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Family"}, "IPR011514": {"description": "Secretin, N-terminal", "go_ids": ["GO:0009297", "GO:0019867"], "go_terms": ["GO:0009297:pilus assembly:P", "GO:0019867:outer membrane:C"], "name": "Secretin_N_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011515": {"description": "Shugoshin, C-terminal", "go_ids": ["GO:0000775", "GO:0005634", "GO:0045132"], "go_terms": ["GO:0000775:chromosome, centromeric region:C", "GO:0005634:nucleus:C", "GO:0045132:meiotic chromosome segregation:P"], "name": "Shugoshin_C", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-MMU-2467813", "R-HSA-69273", "R-MMU-9648025", "R-HSA-141444", "R-HSA-5663220", "R-HSA-9648025", "R-MMU-69273", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR011516": {"description": "Shugoshin, N-terminal coiled-coil domain", "go_ids": [], "go_terms": [], "name": "Shugoshin_N", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-MMU-2467813", "R-HSA-69273", "R-MMU-9648025", "R-HSA-141444", "R-HSA-5663220", "R-HSA-9648025", "R-MMU-69273", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR011517": {"description": "RNA polymerase sigma-70 ECF-like", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma70_ECF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011518": {"description": "Transposase, Rhodopirellula-type", "go_ids": [], "go_terms": [], "name": "Transposase_36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011519": {"description": "ASPIC/UnbV", "go_ids": [], "go_terms": [], "name": "UnbV_ASPIC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011520": {"description": "Vestigial family", "go_ids": ["GO:0005634", "GO:0006355"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Vg_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011521": {"description": "YTV", "go_ids": [], "go_terms": [], "name": "YTV", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011522": {"description": "Thiamin/hydroxymethyl pyrimidine-binding YkoF, putative", "go_ids": [], "go_terms": [], "name": "Thiamin/HMP-bd_put_YkoF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011524": {"description": "SARAH domain", "go_ids": ["GO:0007165"], "go_terms": ["GO:0007165:signal transduction:P"], "name": "SARAH_dom", "pathway_ids": ["R-BTA-2028269", "R-DME-390150", "R-DME-390098", "R-DRE-2028269", "R-CEL-2028269", "R-MMU-2028269", "R-RNO-2028269", "R-DME-390089", "R-DME-451806", "R-DME-2028269", "R-HSA-2028269"], "pathways": ["R-BTA-2028269:r:Signaling by Hippo", "R-DME-390150:r:DS ligand bound to FT receptor", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-DRE-2028269:r:Signaling by Hippo", "R-CEL-2028269:r:Signaling by Hippo", "R-MMU-2028269:r:Signaling by Hippo", "R-RNO-2028269:r:Signaling by Hippo", "R-DME-390089:r:Formation of the Hippo kinase cassette", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-DME-2028269:r:Signaling by Hippo", "R-HSA-2028269:r:Signaling by Hippo"], "type": "Domain"}, "IPR011527": {"description": "ABC transporter type 1, transmembrane domain", "go_ids": ["GO:0005524", "GO:0016020", "GO:0055085", "GO:0140359"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016020:membrane:C", 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"R-RNO-2142691", "R-HSA-9818032", "R-RNO-9749641", "R-HSA-9013406", "R-SPO-1660661", "R-DDI-9753281", "R-MMU-159418", "R-PFA-193368", "R-RNO-390247"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-MMU-9753281:r:Paracetamol ADME", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-1369007:r:Mitochondrial ABC transporters", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DME-422356:r:Regulation of insulin secretion", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9753281:r:Paracetamol ADME", "R-DRE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-2142845:r:Hyaluronan metabolism", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-SCE-9754706:r:Atorvastatin ADME", "R-SCE-114608:r:Platelet degranulation", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-114608:r:Platelet degranulation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-189483:r:Heme degradation", "R-CFA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-CEL-2142845:r:Hyaluronan metabolism", "R-CFA-9707564:r:Cytoprotection by HMOX1", "R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-SPO-9754706:r:Atorvastatin ADME", "R-DME-114608:r:Platelet degranulation", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-9603798:r:Class I peroxisomal membrane protein import", "R-DME-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-9646399:r:Aggrephagy", "R-HSA-9748787:r:Azathioprine ADME", "R-MMU-9758890:r:Transport of RCbl within the body", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DDI-189483:r:Heme degradation", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-1369007:r:Mitochondrial ABC transporters", "R-SPO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9757110:r:Prednisone ADME", "R-HSA-5683177:r:Defective ABCC8 can cause hypo- and hyper-glycemias", "R-HSA-5683371:r:Defective ABCB6 causes MCOPCB7", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-DDI-1369007:r:Mitochondrial ABC transporters", "R-DRE-2046106:r:alpha-linolenic acid (ALA) metabolism", 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signaling", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209560:r:NF-kB is activated and signals survival", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-4755510:r:SUMOylation of immune response proteins", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-RNO-448706:r:Interleukin-1 processing", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-202424:r:Downstream TCR signaling", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-DME-209400:r:Transcriptional activtion by phosphorylated DL/DIF dimer", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-844456:r:The NLRP3 inflammasome", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DME-202424:r:Downstream TCR signaling", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-202424:r:Downstream TCR signaling", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DME-9020702:r:Interleukin-1 signaling", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Domain"}, "IPR011540": {"description": "AbgT, Proteobacteria", "go_ids": ["GO:1902604", "GO:0015558"], "go_terms": ["GO:1902604:p-aminobenzoyl-glutamate transmembrane transport:P", "GO:0015558:secondary active p-aminobenzoyl-glutamate transmembrane transporter activity:F"], "name": "AbgT_Proteobac", "pathway_ids": [], 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"HMG_CoA_synthase_prok", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011555": {"description": "V-ATPase proteolipid subunit C, eukaryotic", "go_ids": ["GO:0046961", "GO:1902600", "GO:0033179"], "go_terms": ["GO:0046961:proton-transporting ATPase activity, rotational mechanism:F", "GO:1902600:proton transmembrane transport:P", "GO:0033179:proton-transporting V-type ATPase, V0 domain:C"], "name": "ATPase_proteolipid_su_C_euk", "pathway_ids": ["R-HSA-6798695", "R-CEL-1222556", "R-MMU-1222556", "R-SPO-6798695", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-CEL-6798695", "R-SCE-6798695", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-RNO-1222556", "R-HSA-9639288", "R-RNO-983712", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-RNO-917977", "R-DDI-6798695", "R-SCE-1222556", "R-SCE-917977", "R-DDI-9639288", "R-MMU-77387", "R-SCE-77387", "R-DME-917977", "R-DME-6798695", "R-DME-77387", "R-RNO-77387", "R-CEL-77387", "R-HSA-983712", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-RNO-9639288", "R-MMU-6798695", "R-HSA-917977", "R-DDI-983712", "R-DDI-917977", "R-MMU-983712", "R-RNO-6798695", "R-DME-9639288"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-RNO-983712:r:Ion channel transport", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-MMU-77387:r:Insulin receptor recycling", "R-SCE-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-77387:r:Insulin receptor recycling", "R-RNO-77387:r:Insulin receptor recycling", "R-CEL-77387:r:Insulin receptor recycling", "R-HSA-983712:r:Ion channel transport", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-DDI-983712:r:Ion channel transport", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR011556": {"description": "Glutamate--cysteine ligase, plant-type", "go_ids": ["GO:0004357", "GO:0006750"], "go_terms": ["GO:0004357:glutamate-cysteine ligase activity:F", "GO:0006750:glutathione biosynthetic process:P"], "name": "Glut_cys_lig_pln_type", "pathway_ids": ["PWY-8043", "PWY-6840", "PWY-7255"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "PWY-6840:t:homoglutathione biosynthesis", "PWY-7255:t:ergothioneine biosynthesis I (bacteria)"], "type": "Family"}, "IPR011557": {"description": "DNA gyrase, subunit B", "go_ids": ["GO:0003677", "GO:0003918", "GO:0005524", "GO:0005694", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F", "GO:0005524:ATP binding:F", "GO:0005694:chromosome:C", "GO:0006265:DNA topological change:P"], "name": "GyrB", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638771"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638771:r:Action of antimicrobials"], "type": "Family"}, "IPR011559": {"description": "Initiation factor 2B alpha/beta/delta", "go_ids": [], "go_terms": [], "name": "Initiation_fac_2B_a/b/d", "pathway_ids": ["PWY-7174", "PWY-8130", "PWY-8132", "PWY-8131", "PWY-4361", "R-DRE-1237112", "R-MMU-1237112", "R-XTR-1237112", "R-SPO-1237112", "R-RNO-1237112", "R-CEL-1237112", "R-DME-1237112", "R-HSA-1237112"], "pathways": ["PWY-7174:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II", "PWY-8130:t:5'-deoxyadenosine degradation I", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8131:t:5'-deoxyadenosine degradation II", "PWY-4361:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I", "R-DRE-1237112:r:Methionine salvage pathway", "R-MMU-1237112:r:Methionine salvage pathway", "R-XTR-1237112:r:Methionine salvage pathway", "R-SPO-1237112:r:Methionine salvage pathway", "R-RNO-1237112:r:Methionine salvage pathway", "R-CEL-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-HSA-1237112:r:Methionine salvage pathway"], "type": "Family"}, "IPR011564": {"description": "Telomeric single stranded DNA binding POT1/Cdc13", "go_ids": ["GO:0000723", "GO:0003677", "GO:0000781"], "go_terms": ["GO:0000723:telomere maintenance:P", "GO:0003677:DNA binding:F", "GO:0000781:chromosome, telomeric region:C"], "name": "Telomer_end-bd_POT1/Cdc13", "pathway_ids": ["R-GGA-174417", "R-MMU-174430", "R-MMU-110330", "R-HSA-171306", "R-HSA-174414", "R-GGA-174437", "R-MMU-2559586", "R-GGA-174411", "R-MMU-174417", "R-HSA-174430", "R-HSA-110328", "R-GGA-174414", "R-GGA-174430", "R-HSA-1221632", "R-HSA-174411", "R-MMU-110331", "R-MMU-9670095", "R-MMU-171319", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-GGA-418124", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-GGA-171319", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-GGA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-GGA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-GGA-174414:r:Processive synthesis on the C-strand of the telomere", "R-GGA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-GGA-418124:r:Telomere maintenance", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-GGA-171319:r:Telomere Extension By Telomerase", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Domain"}, "IPR011566": {"description": "Ubiquinone biosynthesis protein Coq7", "go_ids": ["GO:0006744", "GO:0004497"], "go_terms": ["GO:0006744:ubiquinone biosynthetic process:P", "GO:0004497:monooxygenase activity:F"], "name": "Ubq_synth_Coq7", "pathway_ids": ["PWY-5870", "PWY-5873", "PWY-5871", "PWY-5856", "PWY-6708", "PWY-5857", "PWY-7230", "PWY-5872", "PWY-5855", "R-DDI-2142789", "R-SPO-2142789", "R-SCE-2142789", "R-HSA-2142789", "R-RNO-2142789", "R-MMU-2142789", "R-CEL-2142789"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-CEL-2142789:r:Ubiquinol biosynthesis"], "type": "Family"}, "IPR011576": {"description": "Pyridoxamine 5'-phosphate oxidase, N-terminal", "go_ids": [], "go_terms": [], "name": "Pyridox_Oxase_N", "pathway_ids": ["PWY-7204", "PWY-7282", "R-DDI-964975", "R-BTA-964975", "R-RNO-964975", "R-SCE-964975", "R-HSA-964975", "R-SPO-964975", "R-MMU-964975", "R-CEL-964975"], "pathways": ["PWY-7204:t:pyridoxal 5'-phosphate salvage II (plants)", "PWY-7282:t:4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-BTA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-SCE-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-SPO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate"], "type": "Domain"}, "IPR011577": {"description": "Cytochrome b561, bacterial/Ni-hydrogenase", "go_ids": ["GO:0009055", "GO:0016020"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0016020:membrane:C"], "name": "Cyt_b561_bac/Ni-Hgenase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011579": {"description": "ATPase domain", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "ATPase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011583": {"description": "Chitinase II/V-like, catalytic domain", "go_ids": ["GO:0008061"], "go_terms": ["GO:0008061:chitin binding:F"], "name": "Chitinase_II/V-like_cat", "pathway_ids": ["R-MMU-2534343", "R-HSA-6798695", "R-HSA-189085", "R-DRE-114608", "R-PFA-189085", "R-DME-6798695", "R-CEL-6798695", "R-SCE-6798695", "R-DDI-114608", "R-RNO-114608", "R-CEL-189085", "R-HSA-114608", "R-BTA-114608", "R-HSA-2534343", "R-SCE-189085", "R-PFA-6798695", "R-MMU-6798695", "R-RNO-189085", "R-MMU-189085", "R-XTR-114608", "R-DME-189085", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-DRE-114608:r:Platelet degranulation", "R-PFA-189085:r:Digestion of dietary carbohydrate", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-CEL-189085:r:Digestion of dietary carbohydrate", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-SCE-189085:r:Digestion of dietary carbohydrate", "R-PFA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-XTR-114608:r:Platelet degranulation", "R-DME-189085:r:Digestion of dietary carbohydrate", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR011584": {"description": "Green fluorescent protein-related", "go_ids": ["GO:0008218"], "go_terms": ["GO:0008218:bioluminescence:P"], "name": "GFP-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011589": {"description": "MJ1127-like", "go_ids": [], "go_terms": [], "name": "MJ1127-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011590": {"description": "Transcription elongation factor Spt5, archaeal", "go_ids": ["GO:0003746"], "go_terms": ["GO:0003746:translation elongation factor activity:F"], "name": "Spt5_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011598": {"description": "Myc-type, basic helix-loop-helix (bHLH) domain", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "bHLH_dom", "pathway_ids": ["R-RNO-193807", "R-DRE-211976", "R-DRE-192105", 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["R-HSA-389957:r:Prefoldin mediated transfer of substrate to CCT/TriC"], "type": "Family"}, "IPR011600": {"description": "Peptidase C14, caspase domain", "go_ids": ["GO:0004197", "GO:0006508"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_C14_caspase", "pathway_ids": ["R-DME-198323", "R-RNO-9758274", "R-HSA-5218900", "R-HSA-168638", "R-RNO-9968551", "R-RNO-2028269", "R-MMU-198323", "R-MMU-418889", "R-HSA-9960519", "R-RNO-111465", "R-CEL-9948001", "R-BTA-9948001", "R-HSA-9693928", "R-MMU-3371378", "R-HSA-111463", "R-DME-9948011", "R-MMU-449836", "R-HSA-9956593", "R-HSA-1474228", "R-HSA-140342", "R-RNO-2562578", "R-RNO-6803207", "R-HSA-5674400", "R-MMU-9948011", "R-HSA-9660826", "R-RNO-205025", "R-HSA-9758274", "R-MMU-351906", "R-MMU-111458", "R-HSA-9948001", "R-RNO-75108", "R-HSA-69416", "R-MMU-75108", "R-DME-9948001", "R-HSA-9008059", "R-MMU-69416", "R-MMU-448706", "R-MMU-5357905", "R-DRE-9948001", "R-HSA-264870", "R-HSA-5620971", "R-RNO-351906", "R-DRE-9960519", "R-DME-2028269", "R-RNO-75153", "R-RNO-140342", "R-HSA-5357905", "R-MMU-9627069", "R-RNO-5620971", "R-DME-111458", "R-DME-69416", "R-MMU-6803207", "R-MMU-111464", "R-MMU-5218900", "R-DME-111459", "R-DME-214416", "R-HSA-9627069", "R-RNO-3371378", "R-MMU-111465", "R-MMU-5660668", "R-MMU-202424", "R-DME-214411", "R-DME-5357905", "R-HSA-6803207", "R-DME-5218900", "R-MMU-5675482", "R-MMU-1169091", "R-RNO-111459", "R-RNO-5660668", "R-DME-351906", "R-MMU-75153", "R-MMU-111469", "R-RNO-69416", "R-MMU-9948001", "R-DME-6803207", "R-HSA-933543", "R-MMU-264870", "R-HSA-9948011", "R-HSA-111465", "R-HSA-205025", "R-MMU-2562578", "R-HSA-140534", "R-DME-214399", "R-CEL-198323", "R-HSA-844615", "R-BTA-9948011", "R-DRE-9960525", "R-MMU-5607764", "R-DME-214397", "R-BTA-9960525", "R-RNO-75158", "R-CEL-9948011", "R-RNO-5357905", "R-HSA-351906", "R-DME-418889", "R-DME-352238", "R-RNO-448706", "R-HSA-75108", "R-HSA-9686347", "R-MMU-111459", "R-BTA-9960519", "R-DME-111465", "R-BTA-5620971", "R-DME-264870", "R-RNO-140534", "R-DRE-9948011", "R-HSA-111459", "R-MMU-140534", "R-HSA-5675482", "R-HSA-111458", "R-HSA-75158", "R-HSA-5357786", "R-DME-3371378", "R-HSA-1169091", "R-MMU-6809371", "R-MMU-2871837", "R-RNO-168638", "R-HSA-3371378", "R-MMU-75158", "R-HSA-9968551", "R-HSA-9013957", "R-HSA-844456", "R-HSA-449836", "R-HSA-111469", "R-MMU-9960525", "R-HSA-6809371", "R-HSA-9725554", "R-HSA-9960525", "R-RNO-352238", "R-HSA-418889", "R-RNO-75157", "R-DME-111469", "R-MMU-75157", "R-MMU-205025", "R-HSA-211736", "R-HSA-198323", "R-HSA-2871837", "R-RNO-418889", "R-HSA-448706", "R-HSA-5660668", "R-MMU-9960519", "R-HSA-352238", "R-MMU-168638", "R-HSA-75153", "R-HSA-5607764", "R-MMU-111463", "R-MMU-2028269", "R-DME-9627069", "R-DME-5675482", "R-DME-9758274", "R-HSA-111464", "R-RNO-111469", "R-MMU-352238", "R-HSA-5213460", "R-MMU-140342", "R-HSA-2562578", "R-RNO-5218900", "R-HSA-75157", "R-HSA-9692916", "R-DME-75153", "R-DME-140342", "R-RNO-264870", "R-MMU-5620971", "R-RNO-5675482", "R-MMU-9758274", "R-HSA-202424", "R-RNO-449836", "R-HSA-2028269", "R-HSA-844623"], "pathways": ["R-DME-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-RNO-9968551:r:Regulation of GBP-mediated host defense", "R-RNO-2028269:r:Signaling by Hippo", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-9960519:r:CASP4-mediated substrate cleavage", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-9948001:r:CASP4 inflammasome assembly", "R-BTA-9948001:r:CASP4 inflammasome assembly", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-3371378:r:Regulation by c-FLIP", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-DME-9948011:r:CASP5 inflammasome assembly", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-RNO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-9948011:r:CASP5 inflammasome assembly", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-111458:r:Formation of apoptosome", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-RNO-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-69416:r:Dimerization of procaspase-8", "R-MMU-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-DME-9948001:r:CASP4 inflammasome assembly", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-69416:r:Dimerization of procaspase-8", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-DRE-9948001:r:CASP4 inflammasome assembly", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-5620971:r:Pyroptosis", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-9960519:r:CASP4-mediated substrate cleavage", "R-DME-2028269:r:Signaling by Hippo", "R-RNO-75153:r:Apoptotic execution phase", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-RNO-5620971:r:Pyroptosis", "R-DME-111458:r:Formation of apoptosome", "R-DME-69416:r:Dimerization of procaspase-8", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-RNO-3371378:r:Regulation by c-FLIP", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-202424:r:Downstream TCR signaling", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-5218900:r:CASP8 activity is inhibited", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-5660668:r:CLEC7A/inflammasome pathway", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-75153:r:Apoptotic execution phase", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-69416:r:Dimerization of procaspase-8", "R-MMU-9948001:r:CASP4 inflammasome assembly", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9948011:r:CASP5 inflammasome assembly", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-205025:r:NADE modulates death signalling", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-844615:r:The AIM2 inflammasome", "R-BTA-9948011:r:CASP5 inflammasome assembly", "R-DRE-9960525:r:CASP5-mediated substrate cleavage", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-BTA-9960525:r:CASP5-mediated substrate cleavage", "R-RNO-75158:r:TRAIL signaling", "R-CEL-9948011:r:CASP5 inflammasome assembly", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-352238:r:Breakdown of the nuclear lamina", "R-RNO-448706:r:Interleukin-1 processing", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-BTA-9960519:r:CASP4-mediated substrate cleavage", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-5620971:r:Pyroptosis", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DRE-9948011:r:CASP5 inflammasome assembly", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-75158:r:TRAIL signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-DME-3371378:r:Regulation by c-FLIP", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-3371378:r:Regulation by c-FLIP", "R-MMU-75158:r:TRAIL signaling", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-RNO-352238:r:Breakdown of the nuclear lamina", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-RNO-75157:r:FasL/ CD95L signaling", "R-DME-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-75157:r:FasL/ CD95L signaling", "R-MMU-205025:r:NADE modulates death signalling", "R-HSA-211736:r:Stimulation of the cell death response by PAK-2p34", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-448706:r:Interleukin-1 processing", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-HSA-352238:r:Breakdown of the nuclear lamina", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-75153:r:Apoptotic execution phase", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-MMU-2028269:r:Signaling by Hippo", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-352238:r:Breakdown of the nuclear lamina", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-RNO-5218900:r:CASP8 activity is inhibited", "R-HSA-75157:r:FasL/ CD95L signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DME-75153:r:Apoptotic execution phase", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-5620971:r:Pyroptosis", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR011601": {"description": "UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal", "go_ids": ["GO:0008762"], "go_terms": ["GO:0008762:UDP-N-acetylmuramate dehydrogenase activity:F"], "name": "MurB_C", "pathway_ids": ["PWY-7953", "PWY-6387", "PWY-6386"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "type": "Domain"}, "IPR011602": {"description": "Type II pantothenate kinase, bacterial", "go_ids": ["GO:0004594", "GO:0005524", "GO:0015937"], "go_terms": ["GO:0004594:pantothenate kinase activity:F", "GO:0005524:ATP binding:F", "GO:0015937:coenzyme A biosynthetic process:P"], "name": "Type_II_PanK_bac", "pathway_ids": ["PWY-3961"], "pathways": ["PWY-3961:t:phosphopantothenate biosynthesis II"], "type": "Family"}, "IPR011603": {"description": "2-oxoglutarate dehydrogenase E1 component", "go_ids": ["GO:0016624", "GO:0030976"], "go_terms": ["GO:0016624:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor:F", "GO:0030976:thiamine pyrophosphate binding:F"], "name": "2oxoglutarate_DH_E1", "pathway_ids": ["PWY-5084", "R-DDI-9837999", "R-MMU-9837999", "R-MMU-6783984", "R-CEL-9837999", "R-SCE-9853506", "R-CEL-6783984", "R-SPO-9853506", "R-HSA-9853506", "R-CEL-9853506", "R-SCE-6783984", "R-RNO-9837999", "R-RNO-9858328", "R-RNO-9853506", "R-DDI-9858328", "R-RNO-6783984", "R-HSA-9858328", "R-DDI-9853506", "R-SSC-9853506", "R-SSC-6783984", "R-CEL-9858328", "R-BTA-6783984", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-HSA-6783984", "R-SSC-9837999", "R-DDI-6783984", "R-HSA-9837999", "R-MMU-9858328", "R-SPO-6783984", "R-DRE-9858328", "R-MMU-9853506", "R-DME-9858328", "R-BTA-9853506"], "pathways": ["PWY-5084:t:2-oxoglutarate decarboxylation to succinyl-CoA", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6783984:r:Glycine degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-CEL-6783984:r:Glycine degradation", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-CEL-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SCE-6783984:r:Glycine degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-RNO-6783984:r:Glycine degradation", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-6783984:r:Glycine degradation", "R-CEL-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-BTA-6783984:r:Glycine degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-6783984:r:Glycine degradation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-DDI-6783984:r:Glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SPO-6783984:r:Glycine degradation", "R-DRE-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-DME-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-BTA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG"], "type": "Family"}, "IPR011604": {"description": "PD-(D/E)XK endonuclease-like domain superfamily", "go_ids": [], "go_terms": [], "name": "PDDEXK-like_dom_sf", "pathway_ids": ["R-BTA-69473", "R-RNO-174437", "R-BTA-5685938", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-MMU-6804756", "R-BTA-174437", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-RNO-69166", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-174437", "R-BTA-6804756", "R-BTA-69166", "R-RNO-5685938", "R-BTA-5693616", "R-MMU-174437", "R-RNO-6804756", "R-BTA-5693579", "R-BTA-5693607", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-SPO-69166", "R-MMU-5693607", "R-HSA-9701192", "R-RNO-5693579", "R-BTA-5693568", "R-HSA-69473", "R-RNO-5693607", "R-HSA-9709603", "R-MMU-5685942", "R-HSA-69166", "R-RNO-69473", "R-RNO-5685942", "R-HSA-6804756", "R-HSA-9704331", "R-MMU-69166", "R-RNO-5693568", "R-BTA-5685942", "R-RNO-5693616", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-9913635"], "pathways": ["R-BTA-69473:r:G2/M DNA damage checkpoint", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR011605": {"description": "NusB antitermination factor", "go_ids": ["GO:0006353"], "go_terms": ["GO:0006353:DNA-templated transcription termination:P"], "name": "NusB_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011606": {"description": "Branched-chain amino acid transport, permease", "go_ids": [], "go_terms": [], "name": "Brnchd-chn_aa_trnsp_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011607": {"description": "Methylglyoxal synthase-like domain", "go_ids": [], "go_terms": [], "name": "MGS-like_dom", "pathway_ids": ["R-MMU-500753", "R-SPO-73817", "R-SPO-70635", "R-HSA-500753", "R-SCE-500753", "R-SPO-500753", "R-SCE-73817", "R-HSA-70635", "R-MMU-73817", "R-DDI-500753", "R-HSA-9955542", "R-RNO-70635", "R-GGA-419140", "R-MMU-70635", "R-SCE-70635", "R-DDI-73817", "R-DME-500753", "R-RNO-73817", "R-BTA-73817", "R-CEL-500753", "R-HSA-73817", "R-HSA-9725370"], "pathways": ["R-MMU-500753:r:Pyrimidine biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-70635:r:Urea cycle", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-SCE-500753:r:Pyrimidine biosynthesis", "R-SPO-500753:r:Pyrimidine biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-70635:r:Urea cycle", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-HSA-9955542:r:CPS1 variants cause CPS1 deficiency", "R-RNO-70635:r:Urea cycle", "R-GGA-419140:r:De novo synthesis of IMP", "R-MMU-70635:r:Urea cycle", "R-SCE-70635:r:Urea cycle", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-500753:r:Pyrimidine biosynthesis", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Domain"}, "IPR011608": {"description": "PRD domain", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "PRD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011610": {"description": "S-adenosyl-L-methionine-dependent methyltransferase ML2640-like", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "SAM_mthyl_Trfase_ML2640-like", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR011611": {"description": "Carbohydrate kinase PfkB", "go_ids": [], "go_terms": [], "name": "PfkB_dom", "pathway_ids": ["R-MMU-71336", "R-HSA-71336", "R-DDI-9755088", "R-SCE-9755088", "R-RNO-9755088", "R-RNO-74217", "R-CEL-6798695", "R-HSA-70350", "R-RNO-70350", "R-HSA-5657562", "R-MMU-9755088", "R-SCE-74217", "R-DDI-74217", "R-MMU-74217", "R-CEL-964975", "R-SPO-9755088", "R-HSA-74217", "R-HSA-9755088", "R-DDI-70350", "R-SPO-74217", "R-MMU-70350"], "pathways": ["R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-DDI-9755088:r:Ribavirin ADME", "R-SCE-9755088:r:Ribavirin ADME", "R-RNO-9755088:r:Ribavirin ADME", "R-RNO-74217:r:Purine salvage", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-HSA-5657562:r:Essential fructosuria", "R-MMU-9755088:r:Ribavirin ADME", "R-SCE-74217:r:Purine salvage", "R-DDI-74217:r:Purine salvage", "R-MMU-74217:r:Purine salvage", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-SPO-9755088:r:Ribavirin ADME", "R-HSA-74217:r:Purine salvage", "R-HSA-9755088:r:Ribavirin ADME", "R-DDI-70350:r:Fructose catabolism", "R-SPO-74217:r:Purine salvage", "R-MMU-70350:r:Fructose catabolism"], "type": "Domain"}, "IPR011612": {"description": "Urease alpha-subunit, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Urease_alpha_N_dom", "pathway_ids": ["PWY-5704"], "pathways": ["PWY-5704:t:urea degradation II"], "type": "Domain"}, "IPR011613": {"description": "GH15-like domain", "go_ids": [], "go_terms": [], "name": "GH15-like", "pathway_ids": ["R-MMU-70221", "R-CEL-70221", "R-HSA-70221", "R-RNO-70221", "R-DME-70221"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-CEL-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-DME-70221:r:Glycogen 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"R-HSA-9833482:r:PKR-mediated signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SSC-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-69895:r:Transcriptional activation of cell cycle inhibitor p21"], "type": "Domain"}, "IPR011618": {"description": "Sorbitol phosphotransferase enzyme II, N-terminal", "go_ids": ["GO:0008982", "GO:0009401", "GO:0016020"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_EIIBC_GUT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011620": {"description": "Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004673", "GO:0016020", "GO:0071555"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F", "GO:0016020:membrane:C", "GO:0071555:cell wall organization:P"], "name": "Sig_transdc_His_kinase_LytS_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011621": {"description": "Metal-dependent phosphohydrolase, 7TM intracellular domain", "go_ids": [], "go_terms": [], "name": "Metal-dep_PHydrolase_7TM_intra", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011622": {"description": "7TM-DISM receptor, extracellular domain, type 2", "go_ids": [], "go_terms": [], "name": "7TMR_DISM_rcpt_extracell_dom2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011623": {"description": "7TM-DISM receptor, extracellular domain, type 1", "go_ids": [], "go_terms": [], "name": "7TMR_DISM_rcpt_extracell_dom1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011624": {"description": "Metal-dependent phosphohydrolase, 7TM extracellular domain", "go_ids": [], "go_terms": [], "name": "Metal-dep_PHydrolase_7TM_extra", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011625": {"description": "Alpha-2-macroglobulin, bait region domain", "go_ids": [], "go_terms": [], "name": "A2M_N_BRD", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-MMU-163125", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-163125", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR011626": {"description": "Alpha-macroglobulin-like, TED domain", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Alpha-macroglobulin_TED", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-MMU-163125", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-163125", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR011628": {"description": "Cleaved adhesin", "go_ids": [], "go_terms": [], "name": "Cleaved_adhesin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011629": {"description": "Zinc chaperone CobW-like, C-terminal", "go_ids": [], "go_terms": [], "name": "CobW-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011630": {"description": "Nucleotide modification associated domain 1", "go_ids": [], "go_terms": [], "name": "DUF1599", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011631": {"description": "Protein of unknown function DUF1600", "go_ids": [], "go_terms": [], "name": "DUF1600", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011632": {"description": "Domain of unknown function DUF1601", "go_ids": [], "go_terms": [], "name": "DUF1601", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011635": {"description": "CARDB domain", "go_ids": [], "go_terms": [], "name": "CARDB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011636": {"description": "Thiosulphate:quinone oxidoreductase small subunit DoxA", "go_ids": [], "go_terms": [], "name": "DoxA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011638": {"description": "Sorbitol phosphotransferase enzyme II, C-terminal", "go_ids": ["GO:0008982", "GO:0009401", "GO:0016020"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_EIIBC_GUT_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011639": {"description": "Type II methyltransferase M.TaqI-like domain", "go_ids": ["GO:0006304"], "go_terms": ["GO:0006304:DNA modification:P"], "name": "MethylTrfase_TaqI-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011640": {"description": "Ferrous iron transport protein B, C-terminal", "go_ids": ["GO:0015093", "GO:0016020", "GO:0006826"], "go_terms": ["GO:0015093:ferrous iron transmembrane transporter activity:F", "GO:0016020:membrane:C", "GO:0006826:iron ion transport:P"], "name": "Fe2_transport_prot_B_C", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR011641": {"description": "Tyrosine-protein kinase ephrin type A/B receptor-like", "go_ids": [], "go_terms": [], "name": "Tyr-kin_ephrin_A/B_rcpt-like", "pathway_ids": ["R-HSA-1474228", "R-HSA-3928664", "R-MMU-3928665", "R-RNO-2682334", "R-MMU-2682334", "R-RNO-3928663", "R-MMU-3928663", "R-RNO-3928664", "R-HSA-3928662", "R-HSA-373760", "R-DRE-5362798", "R-HSA-3928663", "R-HSA-5362798", "R-MMU-5362798", "R-HSA-3928665", "R-RNO-3928665", "R-MMU-3928662", "R-RNO-3928662", "R-HSA-2682334", "R-HSA-2892247", "R-MMU-3928664", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-3928664:r:Ephrin signaling", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-373760:r:L1CAM interactions", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-3928664:r:Ephrin signaling", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR011642": {"description": "Nucleoside transporter/FeoB GTPase, Gate domain", "go_ids": [], "go_terms": [], "name": "Gate_dom", "pathway_ids": ["R-MMU-9748787", "R-MMU-9755088", "R-HSA-9638482", "R-HSA-9748787", "R-RNO-83936", "R-HSA-83936", "R-RNO-9748787", "R-RNO-9755088", "R-HSA-9755088", "R-MMU-83936"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-MMU-9755088:r:Ribavirin ADME", "R-HSA-9638482:r:Metal ion assimilation from the host", "R-HSA-9748787:r:Azathioprine ADME", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-9748787:r:Azathioprine ADME", "R-RNO-9755088:r:Ribavirin ADME", "R-HSA-9755088:r:Ribavirin ADME", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "type": "Domain"}, "IPR011643": {"description": "High-CO2 inducible periplasmic protein", "go_ids": [], "go_terms": [], "name": "HCR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011644": {"description": "Heme NO-binding", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "Heme_NO-bd", "pathway_ids": ["R-BTA-445355", "R-HSA-445355", "R-RNO-445355", "R-HSA-392154", "R-MMU-445355", "R-DME-445355"], "pathways": ["R-BTA-445355:r:Smooth Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-445355:r:Smooth Muscle Contraction", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction"], "type": "Domain"}, "IPR011645": {"description": "Haem NO binding associated", "go_ids": ["GO:0004383", "GO:0006182"], "go_terms": ["GO:0004383:guanylate cyclase activity:F", "GO:0006182:cGMP biosynthetic process:P"], "name": "HNOB_dom_associated", "pathway_ids": ["R-BTA-445355", "R-HSA-445355", "R-RNO-445355", "R-HSA-392154", "R-HSA-2514859", "R-MMU-2514859", "R-MMU-445355", "R-DME-445355", "R-RNO-2514859"], "pathways": ["R-BTA-445355:r:Smooth Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-445355:r:Smooth Muscle Contraction", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Domain"}, "IPR011646": {"description": "KAP family P-loop domain", "go_ids": [], "go_terms": [], "name": "KAP_P-loop", "pathway_ids": ["R-DRE-9696273", "R-HSA-9696270", "R-RNO-9696270", "R-HSA-9696273", "R-RNO-9696273", "R-RNO-170984", "R-DRE-9696270", "R-HSA-170984", "R-DRE-170984"], "pathways": ["R-DRE-9696273:r:RND1 GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-170984:r:ARMS-mediated activation", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-170984:r:ARMS-mediated activation", "R-DRE-170984:r:ARMS-mediated activation"], "type": "Domain"}, "IPR011648": {"description": "Circadian clock oscillator protein KaiA", "go_ids": ["GO:0006468", "GO:0007623"], "go_terms": ["GO:0006468:protein phosphorylation:P", "GO:0007623:circadian rhythm:P"], "name": "Circadian_clock_KaiA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011649": {"description": "KaiB domain", "go_ids": ["GO:0048511"], "go_terms": ["GO:0048511:rhythmic process:P"], "name": "KaiB_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011650": {"description": "Peptidase M20, dimerisation domain", "go_ids": [], "go_terms": [], "name": "Peptidase_M20_dimer", "pathway_ids": ["R-XTR-9673163", "R-MMU-9753281", "R-RNO-174403", "R-RNO-9753281", "R-RNO-5423646", "R-DDI-9673163", "R-HSA-5423646", "R-HSA-9753281", "R-MMU-9673163", "R-SPO-9673163", "R-SCE-9673163", "R-SCE-174403", "R-HSA-9673163", "R-MMU-5423646", "R-HSA-174403", "R-BTA-174403", "R-MMU-174403", "R-SPO-174403", "R-HSA-5579007", "R-DDI-5423646", "R-SPO-9753281", "R-SCE-9753281", "R-DDI-9753281", "R-BTA-9753281", "R-DRE-9673163"], "pathways": ["R-XTR-9673163:r:Oleoyl-phe metabolism", "R-MMU-9753281:r:Paracetamol ADME", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-RNO-9753281:r:Paracetamol ADME", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-DDI-9673163:r:Oleoyl-phe metabolism", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-HSA-9753281:r:Paracetamol ADME", "R-MMU-9673163:r:Oleoyl-phe metabolism", "R-SPO-9673163:r:Oleoyl-phe metabolism", "R-SCE-9673163:r:Oleoyl-phe metabolism", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-HSA-9673163:r:Oleoyl-phe metabolism", "R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-HSA-5579007:r:Defective ACY1 causes encephalopathy", "R-DDI-5423646:r:Aflatoxin activation and detoxification", "R-SPO-9753281:r:Paracetamol ADME", "R-SCE-9753281:r:Paracetamol ADME", "R-DDI-9753281:r:Paracetamol ADME", "R-BTA-9753281:r:Paracetamol ADME", "R-DRE-9673163:r:Oleoyl-phe metabolism"], "type": "Domain"}, "IPR011651": {"description": "Notch ligand, N-terminal domain", "go_ids": ["GO:0007219", "GO:0007275", "GO:0016020"], "go_terms": ["GO:0007219:Notch signaling pathway:P", "GO:0007275:multicellular organism development:P", "GO:0016020:membrane:C"], "name": "Notch_ligand_N", "pathway_ids": ["R-HSA-9022702", "R-HSA-8941856", "R-HSA-9725554", "R-HSA-2122948", "R-MMU-2122948", "R-RNO-9013149", "R-HSA-9824272", "R-HSA-9013423", "R-HSA-2979096", "R-HSA-9013700", "R-MMU-9013507", "R-DRE-9013149", "R-HSA-2691232", "R-HSA-9013507", "R-DME-2979096", "R-DME-9013149", "R-DRE-2979096", "R-HSA-2894862", "R-RNO-9013507", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-2660826", "R-HSA-9793380", "R-HSA-9831926", "R-HSA-2644606", "R-MMU-9013149", "R-DME-9013423", "R-DRE-9013423"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9824272:r:Somitogenesis", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-9831926:r:Nephron development", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR011652": {"description": "MORN variant", "go_ids": [], "go_terms": [], "name": "MORN_2", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011653": {"description": "Lipoprotein protein 35", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Lipoprotein_p35", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011655": {"description": "M penetrans paralogue 26", "go_ids": [], "go_terms": [], "name": "MpPF26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011656": {"description": "Notch, NODP domain", "go_ids": ["GO:0007219", "GO:0007275", "GO:0016020", "GO:0030154"], "go_terms": ["GO:0007219:Notch signaling pathway:P", "GO:0007275:multicellular organism development:P", "GO:0016020:membrane:C", "GO:0030154:cell differentiation:P"], "name": "Notch_NODP_dom", "pathway_ids": ["R-XTR-2979096", "R-HSA-8941856", "R-HSA-9604323", "R-HSA-2122948", "R-RNO-9017802", "R-MMU-2122947", "R-XTR-8941856", "R-MMU-2122948", "R-HSA-9818749", "R-XTR-2122948", "R-HSA-9824272", "R-XTR-2197563", "R-XTR-1912420", "R-HSA-1912408", "R-RNO-350054", "R-MMU-1912420", "R-HSA-5083630", "R-HSA-2979096", "R-HSA-9017802", "R-HSA-9818030", "R-HSA-9013700", "R-MMU-9013507", "R-RNO-1912420", "R-HSA-2691232", "R-HSA-9013507", "R-HSA-2122947", "R-MMU-9013700", "R-HSA-1912420", "R-HSA-9013508", "R-CEL-2979096", "R-HSA-210744", "R-HSA-2894862", "R-XTR-9013507", "R-RNO-9013507", "R-MMU-9017802", "R-HSA-350054", "R-MMU-9604323", "R-HSA-9013695", "R-HSA-2644607", "R-HSA-2660826", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-1912399", "R-XTR-9017802"], "pathways": ["R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9824272:r:Somitogenesis", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-CEL-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-XTR-9017802:r:Noncanonical activation of NOTCH3"], "type": "Domain"}, "IPR011657": {"description": "Concentrative nucleoside transporter C-terminal domain", "go_ids": [], "go_terms": [], "name": "CNT_C_dom", "pathway_ids": ["R-MMU-9748787", "R-MMU-9755088", "R-RNO-83936", "R-HSA-9748787", "R-HSA-83936", "R-RNO-9748787", "R-RNO-9755088", "R-HSA-9755088", "R-MMU-83936"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-MMU-9755088:r:Ribavirin ADME", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-9748787:r:Azathioprine ADME", "R-RNO-9755088:r:Ribavirin ADME", "R-HSA-9755088:r:Ribavirin ADME", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "type": "Domain"}, "IPR011658": {"description": "PA14 domain", "go_ids": [], "go_terms": [], "name": "PA14_dom", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Domain"}, "IPR011659": {"description": "TolB-like, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "WD40_TolB-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011660": {"description": "Antitoxin VapB-like", "go_ids": [], "go_terms": [], "name": "VapB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011661": {"description": "Sulphur oxygenase reductase", "go_ids": [], "go_terms": [], "name": "S_Oase_red", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011662": {"description": "Secretin/TonB, short N-terminal domain", "go_ids": ["GO:0019867"], "go_terms": ["GO:0019867:outer membrane:C"], "name": "Secretin/TonB_short_N", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR011663": {"description": "UbiC transcription regulator-associated", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "UTRA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011664": {"description": "Abortive infection system protein AbiD/AbiF-like", "go_ids": [], "go_terms": [], "name": "Abi_system_AbiD/AbiF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011665": {"description": "Brf1, TBP-binding domain", "go_ids": [], "go_terms": [], "name": "BRF1_TBP-bd_dom", "pathway_ids": ["R-SCE-76066", "R-HSA-76066", "R-SPO-76066", "R-HSA-76061", "R-MMU-76061", "R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR011666": {"description": "G patch domain-containing protein, N-terminal", "go_ids": ["GO:0006397"], "go_terms": ["GO:0006397:mRNA processing:P"], "name": "DUF1604", "pathway_ids": ["R-HSA-72163", "R-DME-72163", "R-CEL-72163", "R-SPO-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR011667": {"description": "Uncharacterised protein family UPF0329", "go_ids": [], "go_terms": [], "name": "UPF0329", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011668": {"description": "Ribosomal protein aS21, zinc-binding pocket", "go_ids": [], "go_terms": [], "name": "Ribosomal_aS21_ZBP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011669": {"description": "D-glutamate N-acetyltransferase-like", "go_ids": [], "go_terms": [], "name": "DgcN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011670": {"description": "Domain of unknown function DUF1612", "go_ids": [], "go_terms": [], "name": "DUF1612", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011671": {"description": "tRNA (uracil-O(2)-)-methyltransferase", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "tRNA_uracil_MeTrfase", "pathway_ids": ["PWY-6829", "R-HSA-6782315"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR011672": {"description": "Protein of unknown function DUF1614", "go_ids": [], "go_terms": [], "name": "DUF1614", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011673": {"description": "Protein of unknown function DUF1615", "go_ids": [], "go_terms": [], "name": "DUF1615", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011674": {"description": "Domain of unknown function DUF1616", "go_ids": [], "go_terms": [], "name": "DUF1616", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011675": {"description": "Protein of unknown function DUF1617", "go_ids": [], "go_terms": [], "name": "DUF1617", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011676": {"description": "Domain of unknown function DUF1618", "go_ids": [], "go_terms": [], "name": "DUF1618", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011677": {"description": "Tectonic-1-3 domain", "go_ids": [], "go_terms": [], "name": "TCTN1-3_dom", "pathway_ids": ["R-RNO-5620912", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR011678": {"description": "ER membrane protein complex subunit 1, C-terminal", "go_ids": [], "go_terms": [], "name": "EMC1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011679": {"description": "Endoplasmic reticulum resident protein 29, C-terminal", "go_ids": ["GO:0005783"], "go_terms": ["GO:0005783:endoplasmic reticulum:C"], "name": "ERp29_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011680": {"description": "Fasciculation and elongation protein zeta, FEZ", "go_ids": [], "go_terms": [], "name": "FEZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011681": {"description": "GcrA cell cycle regulator", "go_ids": [], "go_terms": [], "name": "GcrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011682": {"description": "Glycosyl hydrolase family 38, C-terminal", "go_ids": ["GO:0004559", "GO:0006013"], "go_terms": ["GO:0004559:alpha-mannosidase activity:F", "GO:0006013:mannose metabolic process:P"], "name": "Glyco_hydro_38_C", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-MMU-8853383", "R-RNO-8853383", "R-BTA-8853383", "R-HSA-6811438", "R-DME-975578", "R-HSA-975578", "R-HSA-8853383", "R-HSA-9694548", "R-SPO-8853383", "R-MMU-6798695", "R-RNO-975578", "R-BTA-6798695", "R-MMU-975578", "R-DDI-8853383", "R-SCE-8853383"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-BTA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-9694548:r:Maturation of spike protein", "R-SPO-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DDI-8853383:r:Lysosomal oligosaccharide catabolism", "R-SCE-8853383:r:Lysosomal oligosaccharide catabolism"], "type": "Domain"}, "IPR011683": {"description": "Glycosyl hydrolase family 53", "go_ids": ["GO:0015926"], "go_terms": ["GO:0015926:glucosidase activity:F"], "name": "Glyco_hydro_53", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011684": {"description": "Protein Networked (NET), actin-binding (NAB) domain", "go_ids": ["GO:0003779"], "go_terms": ["GO:0003779:actin binding:F"], "name": "NAB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011686": {"description": "Omega transcriptional repressor", "go_ids": [], "go_terms": [], "name": "Omega_repress", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011687": {"description": "Ribosome biogenesis protein Nop53/GLTSCR2", "go_ids": [], "go_terms": [], "name": "Nop53/GLTSCR2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011688": {"description": "PVL Orf50 family", "go_ids": 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{"description": "CobB/CobQ-like glutamine amidotransferase", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "GATase_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011699": {"description": "Mycoplasma MFS transporter", "go_ids": [], "go_terms": [], "name": "MFS_Mycoplasma", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011701": {"description": "Major facilitator superfamily", "go_ids": ["GO:0022857", "GO:0055085"], "go_terms": ["GO:0022857:transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P"], "name": "MFS", "pathway_ids": ["R-HSA-9913143", "R-MMU-8856828", "R-RNO-427652", "R-SPO-181430", "R-SCE-9707616", "R-MMU-210991", "R-DME-9707616", "R-MMU-433692", "R-HSA-8856828", "R-HSA-442660", "R-MMU-181430", "R-MMU-70263", "R-CEL-442660", "R-HSA-5619035", "R-RNO-212676", "R-HSA-70263", "R-HSA-9662360", "R-SPO-8856825", "R-DRE-189200", "R-MMU-196757", "R-MMU-9707616", "R-SPO-917937", "R-HSA-5619071", "R-GGA-373920", "R-MMU-9749641", "R-HSA-4085001", "R-DRE-1660661", "R-SPO-212676", "R-CEL-264642", "R-HSA-210991", "R-HSA-561048", "R-DRE-352230", "R-HSA-210500", "R-CEL-917937", "R-HSA-3229133", "R-HSA-181430", "R-SCE-879518", "R-HSA-5619076", "R-HSA-5250955", "R-RNO-917937", "R-CEL-427652", "R-MMU-427652", "R-CEL-4085001", "R-HSA-264642", "R-HSA-2161517", "R-BTA-9707616", "R-MMU-2160916", "R-HSA-189200", "R-HSA-196757", "R-MMU-264642", "R-MMU-879518", "R-SPO-181429", "R-BTA-442660", "R-HSA-433692", "R-RNO-264642", "R-BTA-917937", "R-XTR-1660661", "R-HSA-9749641", "R-RNO-4085001", "R-HSA-549127", "R-RNO-181429", "R-RNO-433692", "R-HSA-5250992", "R-CEL-8856825", "R-HSA-212676", "R-HSA-189451", "R-SCE-352230", "R-SCE-917937", "R-DME-196757", "R-BTA-210500", "R-HSA-879518", "R-MMU-549127", "R-DME-427652", "R-SSC-9749641", "R-MMU-8856825", "R-MMU-5662702", "R-HSA-2672351", "R-CEL-210500", "R-BTA-352230", "R-DME-264642", "R-XTR-210500", "R-HSA-5250981", "R-MMU-352230", "R-DME-1660661", 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"R-SSC-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-8951664:r:Neddylation", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-8951664:r:Neddylation", "R-DDI-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-SSC-5689880:r:Ub-specific processing proteases", "R-RNO-4641258:r:Degradation of DVL", "R-DRE-5689880:r:Ub-specific processing proteases", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-RNO-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR011706": {"description": "Multicopper oxidase-like, C-terminal", "go_ids": ["GO:0005507", "GO:0016491"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "Cu-oxidase_C", "pathway_ids": ["R-MMU-204005", "R-HSA-9672396", "R-HSA-9674519", "R-MMU-5694530", "R-HSA-140837", "R-HSA-9672397", "R-HSA-9673202", "R-MMU-425410", "R-MMU-8957275", "R-HSA-5694530", "R-HSA-114608", "R-MMU-917937", "R-RNO-425410", "R-RNO-8957275", "R-MMU-381426", "R-HSA-9672387", "R-HSA-9672391", "R-HSA-425410", "R-HSA-381426", "R-HSA-9672395", "R-HSA-9672393", "R-HSA-5619060", "R-HSA-5655799", "R-RNO-917937", "R-MMU-163841", "R-MMU-140837", "R-HSA-140875", "R-HSA-163841", "R-MMU-140875", "R-HSA-204005", "R-RNO-381426", "R-MMU-114608", "R-HSA-917937", "R-HSA-8957275", "R-HSA-5619049", "R-HSA-9672383"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-HSA-9674519:r:Defective F8 sulfation at Y1699", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9672397:r:Defective F8 secretion", "R-HSA-9673202:r:Defective F9 variant does not activate FX", "R-MMU-425410:r:Metal ion SLC transporters", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-114608:r:Platelet degranulation", "R-MMU-917937:r:Iron uptake and transport", "R-RNO-425410:r:Metal ion SLC transporters", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9672387:r:Defective F8 accelerates dissociation of the A2 domain", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-HSA-425410:r:Metal ion SLC transporters", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9672395:r:Defective F8 binding to the cell membrane", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-5619060:r:Defective CP causes aceruloplasminemia (ACERULOP)", "R-HSA-5655799:r:Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-114608:r:Platelet degranulation", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5619049:r:Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)", "R-HSA-9672383:r:Defective factor IX causes thrombophilia"], "type": "Domain"}, "IPR011707": {"description": "Multicopper oxidase-like, N-terminal", "go_ids": ["GO:0005507"], "go_terms": ["GO:0005507:copper ion binding:F"], "name": "Cu-oxidase-like_N", "pathway_ids": ["R-MMU-204005", "R-HSA-9672396", "R-HSA-9674519", "R-MMU-5694530", "R-HSA-140837", "R-HSA-9672397", "R-HSA-9673202", "R-MMU-425410", "R-MMU-8957275", "R-HSA-5694530", "R-HSA-114608", "R-MMU-917937", "R-RNO-425410", "R-RNO-8957275", "R-MMU-381426", "R-HSA-9672387", "R-HSA-9672391", "R-HSA-425410", "R-HSA-381426", "R-HSA-9672395", "R-HSA-9672393", "R-HSA-5619060", "R-HSA-5655799", "R-RNO-917937", "R-MMU-163841", "R-MMU-140837", "R-HSA-140875", "R-HSA-163841", "R-MMU-140875", "R-HSA-204005", "R-RNO-381426", "R-MMU-114608", "R-HSA-917937", "R-HSA-8957275", "R-HSA-5619049", "R-HSA-9672383"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-HSA-9674519:r:Defective F8 sulfation at Y1699", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9672397:r:Defective F8 secretion", "R-HSA-9673202:r:Defective F9 variant does not activate FX", "R-MMU-425410:r:Metal ion SLC transporters", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-114608:r:Platelet degranulation", "R-MMU-917937:r:Iron uptake and transport", "R-RNO-425410:r:Metal ion SLC transporters", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9672387:r:Defective F8 accelerates dissociation of the A2 domain", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-HSA-425410:r:Metal ion SLC transporters", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9672395:r:Defective F8 binding to the cell membrane", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-5619060:r:Defective CP causes aceruloplasminemia (ACERULOP)", "R-HSA-5655799:r:Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-114608:r:Platelet degranulation", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5619049:r:Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)", "R-HSA-9672383:r:Defective factor IX causes thrombophilia"], "type": "Domain"}, "IPR011708": {"description": "Bacterial DNA polymerase III, alpha subunit, NTPase domain", "go_ids": ["GO:0006260", "GO:0008408"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0008408:3'-5' exonuclease activity:F"], "name": "DNA_pol3_alpha_NTPase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011709": {"description": "DEAD-box helicase, OB fold", "go_ids": [], "go_terms": [], "name": "DEAD-box_helicase_OB_fold", "pathway_ids": ["R-CEL-3134963", "R-HSA-9930044", "R-HSA-9833482", "R-MMU-9770562", "R-DME-1810476", "R-DME-6791226", "R-HSA-73856", "R-DME-72163", "R-DDI-9770562", "R-CEL-73856", "R-HSA-72187", "R-RNO-3134963", "R-MMU-3134963", "R-DDI-72163", "R-HSA-6790901", "R-DME-9770562", "R-MMU-9833482", "R-HSA-3134963", "R-SCE-6791226", "R-CEL-9770562", "R-MMU-1810476", "R-CEL-6791226", "R-BTA-3134963", "R-CEL-72163", "R-HSA-9918481", "R-BTA-72163", "R-MMU-9930044", "R-HSA-9770562", "R-MMU-72163", "R-BTA-73856", "R-CEL-9833482", "R-DME-9833482", "R-HSA-1810476", "R-SPO-9770562", "R-HSA-72163", "R-BTA-1810476", "R-HSA-6791226", "R-BTA-9770562", "R-BTA-159236", "R-HSA-159236", "R-SPO-72163", "R-SPO-6791226", "R-BTA-9833482", "R-DME-3134963", "R-CEL-159236"], "pathways": ["R-CEL-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-9770562:r:mRNA Polyadenylation", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-9833482:r:PKR-mediated signaling", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9833482:r:PKR-mediated signaling", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR011710": {"description": "Coatomer beta subunit, C-terminal", "go_ids": ["GO:0005198", "GO:0006886", "GO:0016192", "GO:0030126"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P", "GO:0030126:COPI vesicle coat:C"], "name": "Coatomer_bsu_C", "pathway_ids": ["R-SPO-6807878", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-SCE-6807878", "R-RNO-6811434", "R-SCE-6811434", "R-RNO-6807878", "R-DME-6798695", "R-SCE-6798695", "R-HSA-6807878", "R-BTA-6798695", "R-MMU-6807878", "R-DDI-6811434", "R-GGA-6798695", "R-MMU-6811434", "R-DME-6811434", "R-BTA-6807878", "R-HSA-6811434", "R-DDI-6807878", "R-DRE-6811434", "R-DRE-6798695", "R-DRE-6807878", "R-SPO-6811434", "R-MMU-6798695", "R-DME-6807878", "R-BTA-6811434", "R-RNO-6798695", "R-GGA-6811434", "R-GGA-6807878"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-6798695:r:Neutrophil degranulation", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6798695:r:Neutrophil degranulation", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-6807878:r:COPI-mediated anterograde transport"], "type": "Domain"}, "IPR011711": {"description": "GntR, C-terminal", "go_ids": [], "go_terms": [], "name": "GntR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011712": {"description": "Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain", "go_ids": ["GO:0000155", "GO:0000160", "GO:0016020", "GO:0046983"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0016020:membrane:C", "GO:0046983:protein dimerization activity:F"], "name": "Sig_transdc_His_kin_sub3_dim/P", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011713": {"description": "Leucine-rich repeat 3", "go_ids": [], "go_terms": [], "name": "Leu-rich_rpt_3", "pathway_ids": ["PWY-5381"], "pathways": ["PWY-5381:t:NAD salvage (plants)"], "type": "Repeat"}, "IPR011714": {"description": "Seven residue repeat", "go_ids": [], "go_terms": [], "name": "Seve_residue_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011715": {"description": "Tyrosine aminotransferase ubiquitination region", "go_ids": ["GO:0004838", "GO:0009074", "GO:0030170"], "go_terms": ["GO:0004838:L-tyrosine:2-oxoglutarate transaminase activity:F", "GO:0009074:aromatic amino acid catabolic process:P", "GO:0030170:pyridoxal phosphate binding:F"], "name": "Tyr_aminoTrfase_ubiquitination", "pathway_ids": ["R-RNO-8963684", "R-HSA-8963684", "R-MMU-8963684", "R-BTA-8963684"], "pathways": ["R-RNO-8963684:r:Tyrosine catabolism", "R-HSA-8963684:r:Tyrosine catabolism", "R-MMU-8963684:r:Tyrosine catabolism", "R-BTA-8963684:r:Tyrosine catabolism"], "type": "Conserved_site"}, "IPR011716": {"description": "Tetratricopeptide TPR-3", "go_ids": [], "go_terms": [], "name": "TPR-3", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011717": {"description": "Tetratricopeptide TPR-4", "go_ids": ["GO:0042802"], "go_terms": ["GO:0042802:identical protein binding:F"], "name": "TPR-4", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011718": {"description": "Glutamate--cysteine ligase GshA", "go_ids": [], "go_terms": [], "name": "GshA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011719": {"description": "Conserved hypothetical protein CHP02058", "go_ids": [], "go_terms": [], "name": "CHP02058", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011720": {"description": "Thr operon leader peptide", "go_ids": ["GO:0009088", "GO:0031554", "GO:0031556"], "go_terms": ["GO:0009088:L-threonine biosynthetic process:P", "GO:0031554:regulation of termination of DNA-templated transcription:P", "GO:0031556:transcriptional attenuation by ribosome:P"], "name": "Thr_lead_pept", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011721": {"description": "Conserved hypothetical protein CHP02096", "go_ids": [], "go_terms": [], "name": "CHP02096", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011722": {"description": "Hemimethylated DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Hemimethylated_DNA-bd_dom", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR011723": {"description": "Zinc finger/thioredoxin putative", "go_ids": [], "go_terms": [], "name": "Znf/thioredoxin_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011724": {"description": "Cyd operon protein YbgT", "go_ids": [], "go_terms": [], "name": "Cyd_oper_YbgT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011725": {"description": "Coenzyme PQQ biosynthesis protein A", "go_ids": ["GO:0018189"], "go_terms": ["GO:0018189:pyrroloquinoline quinone biosynthetic process:P"], "name": "PQQ_synth_PqqA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011726": {"description": "K+ transporting P-type ATPase, F subunit", "go_ids": ["GO:0043462", "GO:0008556", "GO:0005886"], "go_terms": ["GO:0043462:regulation of ATP-dependent activity:P", "GO:0008556:P-type potassium transmembrane transporter activity:F", "GO:0005886:plasma membrane:C"], "name": "KdpF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011727": {"description": "Conserved hypothetical protein CHP02117", "go_ids": [], "go_terms": [], "name": "CHP02117", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011728": {"description": "Polyhydroxyalkanoic acid inclusion protein PhaP", "go_ids": [], "go_terms": [], "name": "PhaP_Bmeg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011729": {"description": "Polyhydroxyalkanoic acid synthase, PhaR subunit", "go_ids": [], "go_terms": [], "name": "PhaR_Bmeg_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011732": {"description": "Mycoplasma virulence, signal domain", "go_ids": [], "go_terms": [], "name": "Mycoplasma_virulence_signal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011733": {"description": "Conserved hypothetical CHP02185, integral membrane", "go_ids": [], "go_terms": [], "name": "CHP02185_IM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011735": {"description": "WlaTC/HtrL glycosyltransferase", "go_ids": [], "go_terms": [], "name": "WlaTC/HtrL_glycosyltransf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011736": {"description": "Ehrlichia tandem repeat", "go_ids": [], "go_terms": [], "name": "Ehrlichia_tandem_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011737": {"description": "Uncharacterized protein TP_0381/YwaF", "go_ids": [], "go_terms": [], "name": "TP_0381/YwaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011738": {"description": "Phage conserved hypothetical protein", "go_ids": [], "go_terms": [], "name": "Phage_CHP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011739": {"description": "Gene transfer agent, rcc01693", "go_ids": [], "go_terms": [], "name": "GTA_rcc01693", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011740": {"description": "Domain of unknown function DUF2460", "go_ids": [], "go_terms": [], "name": "DUF2460", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011741": {"description": "Phage conserved hypothetical protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Phg_2220_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011742": {"description": "CRISPR-associated protein, TM1812/MJ1674", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_TM1812", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011743": {"description": "Caa(3)-type oxidase, subunit IV", "go_ids": [], "go_terms": [], "name": "Caa3_sub_IV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011744": {"description": "F0F1-ATPase subunit, putative", "go_ids": [], "go_terms": [], "name": "ATPase_gene1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011745": {"description": "RNA polymerase sigma-70, Myxococcus xanthus", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma70_MYXXA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011746": {"description": "Trp biosynthesis associated, conserved hypothetical membrane protein", "go_ids": [], "go_terms": [], "name": "Trp_synth-assoc_CHP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011747": {"description": "Conserved hypothetical protein CHP02241", "go_ids": [], "go_terms": [], "name": "CHP02241", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011748": {"description": "Uncharacterised protein family, phage tail-like", "go_ids": [], "go_terms": [], "name": "Unchr_phage_tail-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011749": {"description": "Conserved hypothetical protein CHP02243", "go_ids": [], "go_terms": [], "name": "CHP02243", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011750": {"description": "Myxococcus xanthus double-CXXCG motif", "go_ids": [], "go_terms": [], "name": "Gmx_para_CXXCG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011751": {"description": "Myxococcus xanthus paralogous protein 2265", "go_ids": [], "go_terms": [], "name": "Mxa_paralog_2265", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011752": {"description": "PilZ domain, Myxococcales-type", "go_ids": [], "go_terms": [], "name": "PilV_Myxo-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011753": {"description": "DUSAM domain", "go_ids": [], "go_terms": [], "name": "DUSAM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011754": {"description": "Myxococcus xanthus paralogous protein 2268", "go_ids": [], "go_terms": [], "name": "Mxa_paralog_2268", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011755": {"description": "Conserved hypothetical protein CHP02269, MYXXA", "go_ids": [], "go_terms": [], "name": "CHP02269_MYXXA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011757": {"description": "Lytic transglycosylase MltB", "go_ids": [], "go_terms": [], "name": "Lytic_transglycosylase_MltB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011758": {"description": "Alpha-L-glutamate ligase-related protein", "go_ids": [], "go_terms": [], "name": "RimK-rel_E_lig", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011759": {"description": "Cytochrome C oxidase subunit II, transmembrane domain", "go_ids": ["GO:0016020", "GO:0022900"], "go_terms": ["GO:0016020:membrane:C", "GO:0022900:electron transport chain:P"], "name": "Cyt_c_oxidase_su2_TM_dom", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279", "R-GGA-9707564", "R-HSA-5419276", "R-DME-5628897", "R-DRE-611105", "R-GGA-9864848", "R-DRE-9864848", "R-BTA-9864848", "R-HSA-5628897", "R-GGA-5419276", "R-DME-9864848", "R-RNO-5419276", "R-HSA-9707564", "R-GGA-611105", "R-MMU-5628897", "R-MMU-611105", "R-HSA-9837999", "R-MMU-9864848", "R-DRE-5419276", "R-DDI-9837999", "R-DME-9707564", "R-RNO-5628897", "R-RNO-9707564", "R-DME-611105", "R-BTA-5628897", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-GGA-5628897", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-DRE-9707564", "R-DRE-5628897", "R-RNO-9864848", "R-MMU-9707564", "R-BTA-611105", "R-BTA-9707564"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-611105:r:Respiratory electron transport", "R-GGA-9864848:r:Complex IV assembly", "R-DRE-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-5419276:r:Mitochondrial translation termination", "R-DME-9864848:r:Complex IV assembly", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-GGA-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9864848:r:Complex IV assembly", "R-DRE-5419276:r:Mitochondrial translation termination", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-DME-611105:r:Respiratory electron transport", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR011765": {"description": "Peptidase M16, N-terminal", "go_ids": [], "go_terms": [], "name": "Pept_M16_N", "pathway_ids": ["R-MMU-9837999", "R-DDI-611105", "R-BTA-5689880", "R-HSA-5689880", "R-HSA-77387", "R-CEL-9865881", "R-RNO-8949664", "R-MMU-8949664", "R-MMU-9865881", "R-BTA-9033241", "R-MMU-5689880", "R-RNO-9033241", "R-HSA-1268020", "R-BTA-9837999", "R-MMU-1268020", "R-SCE-9033241", "R-MMU-611105", "R-SPO-611105", "R-HSA-8949664", "R-HSA-9837999", "R-BTA-9865881", "R-SCE-1268020", "R-DDI-9033241", "R-DDI-9837999", "R-MMU-77387", "R-HSA-9865881", "R-BTA-8949664", "R-DRE-1268020", "R-CEL-9837999", "R-DME-9033241", "R-XTR-1268020", "R-RNO-9837999", "R-MMU-9033241", "R-SPO-1268020", "R-RNO-77387", "R-RNO-5689880", "R-SCE-9865878", "R-RNO-611105", "R-SPO-9033241", "R-HSA-611105", "R-SPO-9837999", "R-SCE-9837999", "R-CEL-611105", "R-CEL-8949664", "R-RNO-9865881", "R-SCE-611105", "R-BTA-77387", "R-HSA-9033241", "R-DME-5689880", "R-BTA-611105"], "pathways": 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"R-SCE-1268020:r:Mitochondrial protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-9865881:r:Complex III assembly", "R-BTA-8949664:r:Processing of SMDT1", "R-DRE-1268020:r:Mitochondrial protein import", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DME-9033241:r:Peroxisomal protein import", "R-XTR-1268020:r:Mitochondrial protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-SPO-1268020:r:Mitochondrial protein import", "R-RNO-77387:r:Insulin receptor recycling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-611105:r:Respiratory electron transport", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-611105:r:Respiratory electron transport", "R-CEL-8949664:r:Processing of SMDT1", "R-RNO-9865881:r:Complex III assembly", "R-SCE-611105:r:Respiratory electron transport", "R-BTA-77387:r:Insulin receptor recycling", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-5689880:r:Ub-specific processing proteases", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR011766": {"description": "Thiamine pyrophosphate enzyme, TPP-binding", "go_ids": ["GO:0003824", "GO:0030976"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0030976:thiamine pyrophosphate binding:F"], "name": "TPP_enzyme_TPP-bd", "pathway_ids": ["R-RNO-9033241", "R-SPO-389599", "R-SPO-9033241", "R-HSA-389599", "R-DDI-389599", "R-RNO-389599", "R-SCE-9033241", "R-SCE-389599", "R-MMU-9033241", "R-DDI-9033241", "R-HSA-9033241", "R-MMU-389599"], "pathways": ["R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-389599:r:Alpha-oxidation of phytanate", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-DDI-389599:r:Alpha-oxidation of phytanate", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-SCE-9033241:r:Peroxisomal protein import", "R-SCE-389599:r:Alpha-oxidation of phytanate", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-389599:r:Alpha-oxidation of phytanate"], "type": "Domain"}, "IPR011768": {"description": "Translation elongation factor P", "go_ids": ["GO:0003746", "GO:0005737", "GO:0006414"], "go_terms": ["GO:0003746:translation elongation factor activity:F", "GO:0005737:cytoplasm:C", "GO:0006414:translational elongation:P"], "name": "Transl_elongation_fac_P", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011771": {"description": "Magnesium-chelatase, subunit H", "go_ids": ["GO:0015995", "GO:0016851"], "go_terms": ["GO:0015995:chlorophyll biosynthetic process:P", "GO:0016851:magnesium chelatase activity:F"], "name": "BchH", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Family"}, "IPR011773": {"description": "DNA-directed RNA polymerase, alpha subunit", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "DNA-dir_RpoA", "pathway_ids": ["R-HSA-9639775"], "pathways": ["R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb"], "type": "Family"}, "IPR011774": {"description": "Geranylgeranyl reductase, plant/cyanobacteria", "go_ids": [], "go_terms": [], "name": "Geranylgeranyl_Rdtase_pln/cyn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011775": {"description": "Magnesium chelatase, ATPase subunit I", "go_ids": ["GO:0005524", "GO:0016851", "GO:0015995"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016851:magnesium chelatase activity:F", "GO:0015995:chlorophyll biosynthetic process:P"], "name": "Mg_chelatase_ATPase-isu", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Family"}, "IPR011776": {"description": "Magnesium chelatase, ATPase subunit D", "go_ids": ["GO:0005524", "GO:0015995", "GO:0016851"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0015995:chlorophyll biosynthetic process:P", "GO:0016851:magnesium chelatase activity:F"], "name": "Mg_chelatase_ATPase-dsu", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Family"}, "IPR011777": {"description": "Geranylgeranyl reductase family", "go_ids": ["GO:0016628"], "go_terms": ["GO:0016628:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor:F"], "name": "Geranylgeranyl_Rdtase_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011778": {"description": "Hydantoinase/dihydropyrimidinase", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "Hydantoinase/dihydroPyrase", "pathway_ids": ["R-HSA-399956", "R-BTA-399956", "R-MMU-437239", "R-RNO-399956", "R-DDI-73621", "R-RNO-437239", "R-HSA-437239", "R-RNO-73621", "R-HSA-73621", "R-GGA-437239", "R-GGA-399956", "R-DRE-399956", "R-XTR-399956", "R-CEL-399956", "R-MMU-399956", "R-MMU-73621", "R-CEL-73621"], "pathways": ["R-HSA-399956:r:CRMPs in Sema3A signaling", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-DDI-73621:r:Pyrimidine catabolism", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-437239:r:Recycling pathway of L1", "R-RNO-73621:r:Pyrimidine catabolism", "R-HSA-73621:r:Pyrimidine catabolism", "R-GGA-437239:r:Recycling pathway of L1", "R-GGA-399956:r:CRMPs in Sema3A signaling", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-XTR-399956:r:CRMPs in Sema3A signaling", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-73621:r:Pyrimidine catabolism", "R-CEL-73621:r:Pyrimidine catabolism"], "type": "Family"}, "IPR011779": {"description": "Sulphate adenylyltransferase, large subunit", "go_ids": ["GO:0006790"], "go_terms": ["GO:0006790:sulfur compound metabolic process:P"], "name": "SO4_adenylTrfase_lsu", "pathway_ids": ["PWY-6683", "PWY-5278", "PWY-6932", "PWY-5340", "R-MTU-936635"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III", "PWY-5278:t:sulfite oxidation III", "PWY-6932:t:selenate reduction", "PWY-5340:t:sulfate activation for sulfonation", "R-MTU-936635:r:Sulfate assimilation"], "type": "Family"}, "IPR011780": {"description": "D-serine ammonia-lyase", "go_ids": ["GO:0008721", "GO:0030170", "GO:0036088"], "go_terms": ["GO:0008721:D-serine ammonia-lyase activity:F", "GO:0030170:pyridoxal phosphate binding:F", "GO:0036088:D-serine catabolic process:P"], "name": "D_Ser_am_lyase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011781": {"description": "D-serine deaminase transcriptional activator", "go_ids": [], "go_terms": [], "name": "DsdC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011782": {"description": "Peptidase S1C, Do-like", "go_ids": ["GO:0004252", "GO:0006508"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_S1C_Do-like", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR011783": {"description": "Peptidase S1C, DegS", "go_ids": ["GO:0004252", "GO:0006508"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_S1C_DegS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011784": {"description": "Sulphate adenylyltransferase, small subunit", "go_ids": ["GO:0004781", "GO:0000103"], "go_terms": ["GO:0004781:sulfate adenylyltransferase (ATP) activity:F", "GO:0000103:sulfate assimilation:P"], "name": "SO4_adenylTrfase_ssu", "pathway_ids": ["PWY-6683", "PWY-5278", "PWY-6932", "PWY-5340", "R-MTU-936635"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III", "PWY-5278:t:sulfite oxidation III", "PWY-6932:t:selenate reduction", "PWY-5340:t:sulfate activation for sulfonation", "R-MTU-936635:r:Sulfate assimilation"], "type": "Family"}, "IPR011785": {"description": "Transcription regulator PpsR", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_PpsR-CrtJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011786": {"description": "Sulphite reductase (NADPH) hemoprotein, beta subunit", "go_ids": ["GO:0004783", "GO:0008652", "GO:0009337", "GO:0050661", "GO:0051539"], "go_terms": ["GO:0004783:sulfite reductase (NADPH) activity:F", "GO:0008652:amino acid biosynthetic process:P", "GO:0009337:sulfite reductase complex (NADPH):C", "GO:0050661:NADP binding:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "CysI", "pathway_ids": ["PWY-6683"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III"], "type": "Family"}, "IPR011787": {"description": "Sulphite reductase, ferredoxin dependent", "go_ids": ["GO:0020037", "GO:0050311", "GO:0051539"], "go_terms": ["GO:0020037:heme binding:F", "GO:0050311:sulfite reductase (ferredoxin) activity:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "SiR_ferredoxin-dep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011788": {"description": "Zn(II)-responsive transcriptional regulator", "go_ids": ["GO:0003677", "GO:0008270", "GO:0006351"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008270:zinc ion binding:F", "GO:0006351:DNA-templated transcription:P"], "name": "ZntR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011789": {"description": "Cu(I)-responsive transcriptional regulator", "go_ids": ["GO:0003677", "GO:0005507", "GO:0045893", "GO:0003700"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005507:copper ion binding:F", "GO:0045893:positive regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "CueR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011790": {"description": "ADP-specific phosphofructokinase, archaeal", "go_ids": ["GO:0005737", "GO:0006000", "GO:0006096", "GO:0008443"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006000:fructose metabolic process:P", "GO:0006096:glycolytic process:P", "GO:0008443:phosphofructokinase activity:F"], "name": "ADP_PFK_arc", "pathway_ids": ["PWY-6142"], "pathways": ["PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)"], "type": "Family"}, "IPR011791": {"description": "Cd(II)/Pb(II)-responsive 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"Hg(II)-responsive transcriptional regulator", "go_ids": ["GO:0003677", "GO:0045340", "GO:0006355", "GO:0046689"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0045340:mercury ion binding:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0046689:response to mercury ion:P"], "name": "MerR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011795": {"description": "Mercuric transport protein periplasmic component", "go_ids": ["GO:0015097", "GO:0015694", "GO:0042597", "GO:0045340", "GO:0046689"], "go_terms": ["GO:0015097:mercury ion transmembrane transporter activity:F", "GO:0015694:mercury ion transport:P", "GO:0042597:periplasmic space:C", "GO:0045340:mercury ion binding:F", "GO:0046689:response to mercury ion:P"], "name": "MerP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011797": {"description": "Mercuric resistence transcriptional repressor protein MerD", "go_ids": ["GO:0003677", "GO:0045892", "GO:0046689"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0046689:response to mercury ion:P"], "name": "MerD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011798": {"description": "Adenosine 5'-phosphosulphate reductase", "go_ids": ["GO:0004604", "GO:0019344"], "go_terms": ["GO:0004604:phosphoadenylyl-sulfate reductase (thioredoxin) activity:F", "GO:0019344:L-cysteine biosynthetic process:P"], "name": "APS_reductase", "pathway_ids": ["PWY-6683", "R-MTU-936721"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Family"}, "IPR011799": {"description": "Chlorophyll synthase, ChlG", "go_ids": ["GO:0016020", "GO:0015995", "GO:0046408"], "go_terms": ["GO:0016020:membrane:C", "GO:0015995:chlorophyll biosynthetic process:P", "GO:0046408:chlorophyll synthetase activity:F"], "name": "ChlG", "pathway_ids": ["PWY-5064", "PWY-8127", "PWY-8126", "PWY-7764", "PWY-5086", "PWY-5068"], "pathways": ["PWY-5064:t:chlorophyll a biosynthesis II", "PWY-8127:t:chlorophyll b2 biosynthesis", "PWY-8126:t:chlorophyll a2 biosynthesis", "PWY-7764:t:chlorophyll a biosynthesis III", "PWY-5086:t:chlorophyll a biosynthesis I", "PWY-5068:t:chlorophyll cycle"], "type": "Family"}, "IPR011800": {"description": "Phosphoadenosine phosphosulphate reductase CysH", "go_ids": ["GO:0004604"], "go_terms": ["GO:0004604:phosphoadenylyl-sulfate reductase (thioredoxin) activity:F"], "name": "PAPS_reductase_CysH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011801": {"description": "Cyanobacterial long protein repeat", "go_ids": [], "go_terms": [], "name": "Swm_rep_I_cyn", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011802": {"description": "Adenylylsulphate reductase, beta subunit", "go_ids": [], "go_terms": [], "name": "AprB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011803": {"description": "Adenylylsulphate reductase, alpha subunit", "go_ids": [], "go_terms": [], "name": "AprA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011804": {"description": "Ribonuclease II", "go_ids": ["GO:0003723", "GO:0006401", "GO:0008859"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006401:RNA catabolic process:P", "GO:0008859:exoribonuclease II activity:F"], "name": "RNase_II", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011805": {"description": "Ribonuclease R", "go_ids": ["GO:0003723", "GO:0004518"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0004518:nuclease activity:F"], "name": "RNase_R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011806": {"description": "Sulphite reductase, dissimilatory-type alpha subunit", "go_ids": ["GO:0018551", "GO:0020037", "GO:0051539"], "go_terms": ["GO:0018551:dissimilatory sulfite reductase (NADH) activity:F", "GO:0020037:heme binding:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "DsrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011807": {"description": "Exosome complex component Rrp41", "go_ids": ["GO:0000178", "GO:0016896", "GO:0006401"], "go_terms": ["GO:0000178:exosome (RNase complex):C", "GO:0016896:RNA exonuclease activity, producing 5'-phosphomonoesters:F", "GO:0006401:RNA catabolic process:P"], "name": "Rrp41", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011808": {"description": "Sulphite reductase, dissimilatory-type beta subunit", "go_ids": ["GO:0009055", "GO:0018551", "GO:0051539", "GO:0006790"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0018551:dissimilatory sulfite reductase (NADH) activity:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0006790:sulfur compound metabolic process:P"], "name": "DsrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011809": {"description": "Histidinol-phosphate phosphatase, putative, inositol monophosphatase", "go_ids": ["GO:0004401"], "go_terms": ["GO:0004401:histidinol-phosphatase activity:F"], "name": "His_9_proposed", "pathway_ids": ["R-MTU-879299"], "pathways": ["R-MTU-879299:r:Mycothiol biosynthesis"], "type": "Family"}, "IPR011810": {"description": "Cyanophycin synthetase", "go_ids": ["GO:0005524", "GO:0009059", "GO:0016874"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0009059:macromolecule biosynthetic process:P", "GO:0016874:ligase activity:F"], "name": "Cya_phycin_syn", "pathway_ids": ["PWY-7052"], "pathways": ["PWY-7052:t:cyanophycin metabolism"], "type": "Family"}, "IPR011811": {"description": "Peptidase S51, cyanophycinase", "go_ids": ["GO:0016787", "GO:0043170"], "go_terms": ["GO:0016787:hydrolase activity:F", "GO:0043170:macromolecule metabolic process:P"], "name": "Peptidase_S51_cyanophycinase", "pathway_ids": ["PWY-7052"], "pathways": ["PWY-7052:t:cyanophycin metabolism"], "type": "Family"}, "IPR011812": {"description": "Biosynthetic peptidoglycan transglycosylase", "go_ids": ["GO:0009252", "GO:0009274", "GO:0016020", "GO:0016763"], "go_terms": ["GO:0009252:peptidoglycan biosynthetic 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"go_terms": ["GO:0009102:biotin biosynthetic process:P", "GO:0010340:carboxyl-O-methyltransferase activity:F"], "name": "BioC", "pathway_ids": ["PWY-6519"], "pathways": ["PWY-6519:t:8-amino-7-oxononanoate biosynthesis I"], "type": "Family"}, "IPR011815": {"description": "Penicillin-binding protein 1C", "go_ids": ["GO:0009252", "GO:0008955"], "go_terms": ["GO:0009252:peptidoglycan biosynthetic process:P", "GO:0008955:peptidoglycan glycosyltransferase activity:F"], "name": "PBP_1c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011817": {"description": "Uridylate kinase", "go_ids": ["GO:0006221", "GO:0033862"], "go_terms": ["GO:0006221:pyrimidine nucleotide biosynthetic process:P", "GO:0033862:UMP kinase activity:F"], "name": "Uridylate_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011818": {"description": "Uridylate kinase, archaeal/spirochete, putative", "go_ids": ["GO:0006221", "GO:0033862"], "go_terms": ["GO:0006221:pyrimidine nucleotide biosynthetic process:P", "GO:0033862:UMP kinase activity:F"], "name": "Uridylate_kinase_arch/spir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011819": {"description": "Pyrococcus aspartate kinase subunit, putative", "go_ids": [], "go_terms": [], "name": "AspKin_pair", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011820": {"description": "L-threonine dehydratase biosynthetic IlvA", "go_ids": ["GO:0004794"], "go_terms": ["GO:0004794:threonine deaminase activity:F"], "name": "IlvA", "pathway_ids": ["PWY-8443"], "pathways": ["PWY-8443:t:cyclosporin A biosynthesis"], "type": "Family"}, "IPR011821": {"description": "O-succinylhomoserine (thiol)-lyase", "go_ids": [], "go_terms": [], "name": "O_succ_thio_ly", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011822": {"description": "Cobalamin-dependent methionine synthase", "go_ids": ["GO:0008705", "GO:0031419", "GO:0008270"], "go_terms": ["GO:0008705:methionine synthase activity:F", "GO:0031419:cobalamin binding:F", "GO:0008270:zinc ion binding:F"], "name": "MetH", "pathway_ids": ["PWY-3841", "PWY-2201", "R-CEL-156581", "R-RNO-1614635", "R-MMU-9013407", "R-CEL-9759218", "R-RNO-9759218", "R-RNO-9013407", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-DDI-1614635", "R-MMU-9759218", "R-MMU-1614635", "R-HSA-156581", "R-HSA-9759218", "R-RNO-156581", "R-HSA-3359467", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["PWY-3841:t:folate transformations II (plants)", "PWY-2201:t:folate transformations I", "R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-156581:r:Methylation", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR011823": {"description": "3-isopropylmalate dehydratase, large subunit, bacteria", "go_ids": ["GO:0003861", "GO:0009098", "GO:0051539"], "go_terms": ["GO:0003861:3-isopropylmalate dehydratase activity:F", "GO:0009098:L-leucine biosynthetic process:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "IsopropMal_deHydtase_lsu_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011824": {"description": "Hydrolyase LeuD/DmdB, bacterial", "go_ids": ["GO:0016836"], "go_terms": ["GO:0016836:hydro-lyase activity:F"], "name": "LeuD/DmdB_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011825": {"description": "23S rRNA (uracil(747)-C(5))-methyltransferase RlmC", "go_ids": ["GO:0016070", "GO:0016436"], "go_terms": ["GO:0016070:RNA metabolic process:P", "GO:0016436:rRNA (uridine) methyltransferase activity:F"], "name": "23SrRNA_MeTrfase_RlmC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011826": {"description": "Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic", "go_ids": ["GO:0003861", "GO:0009098", "GO:0051539"], "go_terms": ["GO:0003861:3-isopropylmalate dehydratase activity:F", "GO:0009098:L-leucine biosynthetic process:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "HAcnase/IPMdehydase_lsu_prok", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011827": {"description": "Hydrolyase LeuD/HacB/DmdB", "go_ids": ["GO:0016836"], "go_terms": ["GO:0016836:hydro-lyase activity:F"], "name": "LeuD_type2/HacB/DmdB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011828": {"description": "Isopropylmalate/isohomocitrate dehydrogenase", "go_ids": ["GO:0003862", "GO:0009098", "GO:0051287"], "go_terms": ["GO:0003862:3-isopropylmalate dehydrogenase activity:F", "GO:0009098:L-leucine biosynthetic process:P", "GO:0051287:NAD binding:F"], "name": "LEU3_arc", "pathway_ids": ["PWY-7396"], "pathways": ["PWY-7396:t:butanol and isobutanol biosynthesis (engineered)"], "type": "Family"}, "IPR011829": {"description": "Tartrate dehydrogenase", "go_ids": ["GO:0051287", "GO:0016616"], "go_terms": ["GO:0051287:NAD binding:F", "GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "TTC_DH", "pathway_ids": ["PWY-7469"], "pathways": ["PWY-7469:t:gentisate degradation II"], "type": "Family"}, "IPR011830": {"description": "Isopropylmalate/citramalate/homocitrate synthase", "go_ids": ["GO:0019752", "GO:0046912"], "go_terms": ["GO:0019752:carboxylic acid metabolic process:P", "GO:0046912:acyltransferase activity, acyl groups converted into alkyl on transfer:F"], "name": "LEU1_arch", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011831": {"description": "Glucose-1-phosphate adenylyltransferase", "go_ids": ["GO:0008878", "GO:0005978"], "go_terms": ["GO:0008878:glucose-1-phosphate adenylyltransferase activity:F", "GO:0005978:glycogen biosynthetic process:P"], "name": "ADP-Glc_PPase", "pathway_ids": ["PWY-7902", "PWY-622"], "pathways": ["PWY-7902:t:glucosylglycerol biosynthesis", "PWY-622:t:starch biosynthesis"], "type": "Family"}, "IPR011832": {"description": "Glucose-1-phosphate adenylyltransferase, GlgD subunit", "go_ids": ["GO:0005978"], "go_terms": ["GO:0005978:glycogen biosynthetic process:P"], "name": "GlgDAde_trans", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011833": {"description": "Glycogen/starch/alpha-glucan phosphorylase", "go_ids": ["GO:0004645", "GO:0005975", "GO:0030170"], "go_terms": ["GO:0004645:1,4-alpha-oligoglucan phosphorylase activity:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0030170:pyridoxal phosphate binding:F"], "name": "Glycg_phsphrylas", "pathway_ids": ["PWY-7238", "PWY-6731", "PWY-5941", "PWY-6737", "R-MMU-70221", "R-HSA-6798695", "R-DDI-6798695", "R-HSA-70221", "R-RNO-70221", "R-SCE-70221", "R-DME-70221", "R-DME-6798695", "R-SCE-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-RNO-6798695", "R-DDI-70221", "R-BTA-70221"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6731:t:starch degradation III", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V", "R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-DME-70221:r:Glycogen breakdown (glycogenolysis)", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-70221:r:Glycogen breakdown (glycogenolysis)", "R-BTA-70221:r:Glycogen breakdown (glycogenolysis)"], "type": "Family"}, "IPR011834": {"description": "Alpha-glucan phosphorylase", "go_ids": ["GO:0004645", "GO:0005975", "GO:0030170"], "go_terms": ["GO:0004645:1,4-alpha-oligoglucan phosphorylase activity:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0030170:pyridoxal phosphate binding:F"], "name": "Agluc_phsphrylas", "pathway_ids": ["PWY-7238", "PWY-6731", "PWY-5941", "PWY-6737"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6731:t:starch degradation III", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V"], "type": "Family"}, "IPR011835": {"description": "Bacterial/plant glycogen synthase", "go_ids": ["GO:0004373"], "go_terms": ["GO:0004373:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity:F"], "name": "GS/SS", "pathway_ids": ["PWY-622"], "pathways": ["PWY-622:t:starch biosynthesis"], "type": "Family"}, "IPR011836": {"description": "YhdP", "go_ids": [], "go_terms": [], "name": "YhdP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011837": {"description": "Glycogen debranching enzyme, GlgX type", "go_ids": ["GO:0004553", "GO:0005980", "GO:0004135"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0005980:glycogen catabolic process:P", "GO:0004135:amylo-alpha-1,6-glucosidase activity:F"], "name": "Glycogen_debranch_GlgX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011838": {"description": "Pullulanase, extracellular", "go_ids": [], "go_terms": [], "name": "Pullulan_Gpos", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011839": {"description": "Alpha-1,6-glucosidases, pullulanase-type", "go_ids": ["GO:0005975", "GO:0051060"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0051060:pullulanase activity:F"], "name": "Pullul_strch", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011840": {"description": "Pullulanase, type I", "go_ids": [], "go_terms": [], "name": "PulA_typeI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011841": {"description": "Type III secretion system, needle protein", "go_ids": ["GO:0030257", "GO:0030254"], "go_terms": ["GO:0030257:type III protein secretion system complex:C", "GO:0030254:protein secretion by the type III secretion system:P"], "name": "T3SS_needle_YscF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011842": {"description": "Coenzyme PQQ biosynthesis protein B", "go_ids": [], "go_terms": [], "name": "PQQ_synth_PqqB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011843": {"description": "Coenzyme PQQ biosynthesis protein E, bacteria", "go_ids": ["GO:0018189", "GO:0051539"], "go_terms": ["GO:0018189:pyrroloquinoline quinone biosynthetic process:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "PQQ_synth_PqqE_bac", "pathway_ids": ["PWY-6420"], "pathways": ["PWY-6420:t:pyrroloquinoline quinone biosynthesis"], "type": "Family"}, "IPR011844": {"description": "Coenzyme PQQ biosynthesis protein PqqF", "go_ids": ["GO:0008270", "GO:0018189", "GO:0004222", "GO:0006508"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0018189:pyrroloquinoline quinone biosynthetic process:P", "GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "PQQ_synth_PqqF", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR011845": {"description": "Coenzyme PQQ biosynthesis protein C", "go_ids": ["GO:0018189"], "go_terms": ["GO:0018189:pyrroloquinoline quinone biosynthetic process:P"], "name": "PqqC", "pathway_ids": ["PWY-6420"], "pathways": ["PWY-6420:t:pyrroloquinoline quinone biosynthesis"], "type": "Family"}, "IPR011846": {"description": "Cyd operon protein YbgE", "go_ids": [], "go_terms": [], "name": "Cyd_oper_YbgE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011847": {"description": "Phosphopantothenoylcysteine decarboxylase", "go_ids": [], "go_terms": [], "name": "CoaC_strep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011848": {"description": "Phosphopantothenate--cysteine ligase", "go_ids": [], "go_terms": [], "name": "CoaB_strep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011849": {"description": "Sodium/pantothenate symporter", "go_ids": ["GO:0015081", "GO:0015233", "GO:0015887", "GO:0016020", "GO:0036376"], "go_terms": ["GO:0015081:sodium ion transmembrane transporter activity:F", "GO:0015233:pantothenate transmembrane transporter activity:F", "GO:0015887:pantothenate transmembrane transport:P", "GO:0016020:membrane:C", "GO:0036376:sodium ion export across plasma membrane:P"], "name": "Na/pantothenate_symporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011850": {"description": "Type II secretion system protein GspF", "go_ids": ["GO:0015627", "GO:0015628"], "go_terms": ["GO:0015627:type II protein secretion system complex:C", "GO:0015628:protein secretion by the type II secretion system:P"], "name": "T2SS_GspF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011851": {"description": "Sodium/proline symporter", "go_ids": ["GO:0005298", "GO:0006814", "GO:0015824", "GO:0016020", "GO:0031402"], "go_terms": ["GO:0005298:proline:sodium symporter activity:F", "GO:0006814:sodium ion transport:P", "GO:0015824:proline transport:P", "GO:0016020:membrane:C", "GO:0031402:sodium ion binding:F"], "name": "Na/Pro_symporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011852": {"description": "TRAP transporter solute receptor, TAXI family", "go_ids": [], "go_terms": [], "name": "TRAP_TAXI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011853": {"description": "TRAP C4-dicarboxylate transport system permease, fused DctM-DctQ", "go_ids": [], "go_terms": [], "name": "TRAP_DctM-Dct_fused", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011854": {"description": "Carbamoyl dehydratase HypE", "go_ids": [], "go_terms": [], "name": "HypE", "pathway_ids": ["PWY-7045", "PWY-8319", "PWY-7811", "PWY-6322", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7814", "PWY-6627", "PWY-6946", "PWY-6945", "PWY-7188", "PWY-5780", "PWY-7897", "PWY-7275", "PWY-5367", "PWY-8152", "PWY-8029", "PWY-6948", "PWY-8134", "PWY-7610", "PWY-7695", "PWY-7354", "PWY-8335", "PWY-6944", "PWY-7547", "PWY-8012", "PWY-2229", "PWY-5793", "PWY-7352", "PWY-2467", "PWY-8044", "PWY-6602", "PWY-6679", "PWY-7757", "PWY-7510", "PWY-5979", "PWY-721", "PWY-5644", "PWY-5408", "PWY-7821", "PWY-7189", "PWY-5410", "PWY-7613", "PWYG-321", "PWY-5061", "PWY-6721", "PWY-6672", "PWY-5409", "PWY-6749", "PWY-7428", "PWY-8151"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-8319:t:NiFe(CO)(CN)2 cofactor biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7188:t:orientin and isoorientin biosynthesis I", "PWY-5780:t:hypericin biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-7275:t:L-homophenylalanine biosynthesis", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-8134:t:bile acid 7beta-dehydroxylation", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-8335:t:plasmalogen biosynthesis II (anaerobic)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7547:t:prodigiosin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-2229:t:superpathway of pterocarpan biosynthesis (via formononetin)", "PWY-5793:t:maysin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-2467:t:(+)-pisatin biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6602:t:naringenin C-glucosylation", "PWY-6679:t:jadomycin biosynthesis", "PWY-7757:t:bisphenol A degradation", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-721:t:3-methylquinoline degradation", "PWY-5644:t:4-nitrotoluene degradation II", "PWY-5408:t:9-lipoxygenase and 9-hydroperoxide lyase pathway", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7189:t:pinocembrin C-glucosylation", "PWY-5410:t:traumatin and (Z)-3-hexen-1-yl acetate biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5061:t:6,7,4'-trihydroxyisoflavone biosynthesis", "PWY-6721:t:sangivamycin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-5409:t:divinyl ether biosynthesis II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7428:t:2-chloroacrylate degradation II", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)"], "type": "Family"}, "IPR011855": {"description": "Phage major tail protein TP901-1", "go_ids": [], "go_terms": [], "name": "Phgtail_TP901_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011856": {"description": "tRNA endonuclease-like domain superfamily", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "tRNA_endonuc-like_dom_sf", "pathway_ids": ["R-MMU-6783310", "R-HSA-6783310", "R-HSA-6784531", "R-DRE-6783310"], "pathways": ["R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DRE-6783310:r:Fanconi Anemia Pathway"], "type": "Homologous_superfamily"}, "IPR011858": {"description": "His6/HISN3", "go_ids": ["GO:0000105", "GO:0003949"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0003949:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity:F"], "name": "His6/HISN3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011859": {"description": "Dihydrodipicolinate reductase, plant-type", "go_ids": ["GO:0008839", "GO:0070402", "GO:0009085"], "go_terms": ["GO:0008839:4-hydroxy-tetrahydrodipicolinate reductase activity:F", "GO:0070402:NADPH binding:F", "GO:0009085:L-lysine biosynthetic process:P"], "name": "Dihydrodipicolinate_Rdtase_pln", "pathway_ids": ["PWY-5097", "PWY-2942", "PWY-2941"], "pathways": ["PWY-5097:t:L-lysine biosynthesis VI", "PWY-2942:t:L-lysine biosynthesis III", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Family"}, "IPR011860": {"description": "Ribose 5-phosphate isomerase B, Actinobacteria-type", "go_ids": [], "go_terms": [], "name": "Rib-5-P_Isoase_Actino", "pathway_ids": ["PWY-1861", "PWY-8178", "PWY-5723"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-5723:t:Rubisco shunt"], "type": "Family"}, "IPR011861": {"description": "Transaldolase, Staphylococcus-type", "go_ids": [], "go_terms": [], "name": "Transald_staph-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011862": {"description": "Phosphate binding protein", "go_ids": ["GO:0042301"], "go_terms": ["GO:0042301:phosphate ion binding:F"], "name": "Phos-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011863": {"description": "Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein", "go_ids": [], "go_terms": [], "name": "HSK-PSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011864": {"description": "Phosphate ABC transporter, permease protein PstC", "go_ids": ["GO:0005315", "GO:0006817", "GO:0016020"], "go_terms": ["GO:0005315:phosphate transmembrane transporter activity:F", "GO:0006817:phosphate ion transport:P", "GO:0016020:membrane:C"], "name": "Phosphate_PstC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011865": {"description": "Sulphate ABC transporter, permease protein CysT", "go_ids": ["GO:1902358", "GO:0005886", "GO:0015419"], "go_terms": ["GO:1902358:sulfate transmembrane transport:P", "GO:0005886:plasma membrane:C", "GO:0015419:ABC-type sulfate transporter activity:F"], "name": "CysT_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011866": {"description": "Sulphate ABC transporter, permease protein CysW", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "CysW_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011867": {"description": "Molybdenum transport system permease protein ModB", "go_ids": ["GO:0015098", "GO:0015689", "GO:0016020"], "go_terms": ["GO:0015098:molybdate ion transmembrane transporter activity:F", "GO:0015689:molybdate ion transport:P", "GO:0016020:membrane:C"], "name": "ModB_ABC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011868": {"description": "Molybdate ABC transporter, ATP-binding protein", "go_ids": ["GO:0005524", "GO:0015098", "GO:0015689", "GO:0016020", "GO:0140359"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0015098:molybdate ion transmembrane transporter activity:F", "GO:0015689:molybdate ion transport:P", "GO:0016020:membrane:C", "GO:0140359:ABC-type transporter activity:F"], "name": "ModC_ABC_ATP-bd", "pathway_ids": ["PWY-8171"], "pathways": ["PWY-8171:t:molybdenum cofactor biosynthesis"], "type": "Family"}, "IPR011869": {"description": "tRNA/tmRNA (uracil-C(5))-methyltransferase, TrmA", "go_ids": ["GO:0030697", "GO:0006396"], "go_terms": ["GO:0030697:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent:F", "GO:0006396:RNA processing:P"], "name": "TrmA_MeTrfase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR011870": {"description": "Lysine biosynthesis enzyme LysX", "go_ids": ["GO:0003824", "GO:0005524", "GO:0009085"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0005524:ATP binding:F", "GO:0009085:L-lysine biosynthetic process:P"], "name": "LysX_arch", "pathway_ids": ["PWY-3081"], "pathways": ["PWY-3081:t:L-lysine biosynthesis V"], "type": "Family"}, "IPR011871": {"description": "Fibrobacter succinogenes major paralogous domain", "go_ids": [], "go_terms": [], "name": "Fib_succ_major", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011872": {"description": "Homocitrate synthase", "go_ids": ["GO:0019752", "GO:0046912", "GO:0004410", "GO:0009085"], "go_terms": ["GO:0019752:carboxylic acid metabolic process:P", "GO:0046912:acyltransferase activity, acyl groups converted into alkyl on transfer:F", "GO:0004410:homocitrate synthase activity:F", "GO:0009085:L-lysine biosynthetic process:P"], "name": "Homocitrate_synth", "pathway_ids": ["PWY-7710", "PWY-3081"], "pathways": ["PWY-7710:t:FeMo cofactor biosynthesis", "PWY-3081:t:L-lysine biosynthesis V"], "type": "Family"}, "IPR011873": {"description": "Conserved hypothetical protein CHP02147", "go_ids": [], "go_terms": [], "name": "CHP02147", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011874": {"description": "Fibro-slime", "go_ids": [], "go_terms": [], "name": "Fibro_Slime", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011875": {"description": "Alpha-maltose-1-phosphate synthase", "go_ids": ["GO:0009250", "GO:0016740"], "go_terms": ["GO:0009250:glucan biosynthetic process:P", "GO:0016740:transferase activity:F"], "name": "M1P_synthase", "pathway_ids": ["PWY-7900"], "pathways": ["PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)"], "type": "Family"}, "IPR011876": {"description": "Isopentenyl-diphosphate delta-isomerase, type 1", "go_ids": ["GO:0004452", "GO:0008299"], "go_terms": ["GO:0004452:isopentenyl-diphosphate delta-isomerase activity:F", "GO:0008299:isoprenoid biosynthetic process:P"], "name": "IsopentenylPP_isomerase_typ1", "pathway_ids": ["PWY-7102", "PWY-7524", "PWY-6859", "PWY-6383", "PWY-7391", "PWY-7560", "PWY-922", "PWY-8125", "PWY-6174", "R-SCE-9969896", "R-DDI-9969896", "R-HSA-9969896", "R-MMU-9969896", "R-HSA-2426168", "R-RNO-9969896", "R-SPO-9969896"], "pathways": ["PWY-7102:t:bisabolene biosynthesis (engineered)", "PWY-7524:t:mevalonate pathway III (Thermoplasma)", "PWY-6859:t:all-trans-farnesol biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-7560:t:methylerythritol phosphate pathway II", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "PWY-8125:t:mevalonate pathway IV (archaea)", "PWY-6174:t:mevalonate pathway II (haloarchaea)", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR011878": {"description": "Glutamyl-tRNA(Gln) amidotransferase subunit D", "go_ids": ["GO:0006450"], "go_terms": ["GO:0006450:regulation of translational fidelity:P"], "name": "GatD", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Family"}, "IPR011879": {"description": "Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB", "go_ids": ["GO:0000156", "GO:0000160", "GO:0003677", "GO:0006817"], "go_terms": ["GO:0000156:phosphorelay response regulator activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0003677:DNA binding:F", "GO:0006817:phosphate ion transport:P"], "name": "Sig_transdc_resp-reg_PhoB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011880": {"description": "Phenylacetate-CoA ligase", "go_ids": ["GO:0010124", "GO:0047475"], "go_terms": ["GO:0010124:phenylacetate catabolic process:P", "GO:0047475:phenylacetate-CoA ligase activity:F"], "name": "PA_CoA_ligase", "pathway_ids": ["PWY-6318", "PWY-7716", "PWY-1341"], "pathways": ["PWY-6318:t:L-phenylalanine degradation IV (mammalian, via side chain)", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-1341:t:phenylacetate degradation II (anaerobic)"], "type": "Family"}, "IPR011881": {"description": "1,2-phenylacetyl-CoA epoxidase, subunit A", "go_ids": ["GO:0097266", "GO:0010124"], "go_terms": ["GO:0097266:phenylacetyl-CoA 1,2-epoxidase activity:F", "GO:0010124:phenylacetate catabolic process:P"], "name": "PaaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011882": {"description": "1,2-phenylacetyl-CoA epoxidase, subunit C", "go_ids": ["GO:0010124"], "go_terms": ["GO:0010124:phenylacetate catabolic process:P"], "name": "PaaC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011883": {"description": "1,2-phenylacetyl-CoA epoxidase, subunit D", "go_ids": [], "go_terms": [], "name": "PaaD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011884": {"description": "1,2-phenylacetyl-CoA epoxidase, subunit E", "go_ids": ["GO:0010124"], "go_terms": ["GO:0010124:phenylacetate catabolic process:P"], "name": "PaaE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011885": {"description": "Periplasmic nitrate reductase c-type cytochrome, NapC/NirT", "go_ids": ["GO:0016020", "GO:0020037", "GO:0019333"], "go_terms": ["GO:0016020:membrane:C", "GO:0020037:heme binding:F", "GO:0019333:denitrification pathway:P"], "name": "NO3Rdtase_cyt_c_NapC/NirT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011886": {"description": "Ferredoxin-type protein, NapH/MauN family", "go_ids": [], "go_terms": [], "name": "NapH_MauN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011887": {"description": "Trimethylamine-N-oxide reductase TorA", "go_ids": ["GO:0030151", "GO:0042597", "GO:0050626"], "go_terms": ["GO:0030151:molybdenum ion binding:F", "GO:0042597:periplasmic space:C", "GO:0050626:trimethylamine-N-oxide reductase (cytochrome c) activity:F"], "name": "TorA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011888": {"description": "Anaerobic dimethyl sulphoxide reductase, subunit A, DmsA/YnfE", "go_ids": ["GO:0009389", "GO:0030151", "GO:0051539"], "go_terms": ["GO:0009389:dimethyl sulfoxide reductase activity:F", "GO:0030151:molybdenum ion binding:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Anaer_DMSO_reductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011889": {"description": "Bacterial surface protein 26-residue repeat", "go_ids": [], "go_terms": [], "name": "Liste_lipo_26", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011890": {"description": "Structural maintenance of chromosomes protein, prokaryotic", "go_ids": ["GO:0007062", "GO:0030261"], "go_terms": ["GO:0007062:sister chromatid cohesion:P", "GO:0030261:chromosome condensation:P"], "name": "SMC_prok", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011892": {"description": "Cytidylate kinase, archaeal-type", "go_ids": ["GO:0005524", "GO:0006139", "GO:0016776"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006139:nucleobase-containing compound metabolic process:P", "GO:0016776:phosphotransferase activity, phosphate group as acceptor:F"], "name": "Cyt_kin_arch", "pathway_ids": ["PWY-7205"], "pathways": ["PWY-7205:t:CMP phosphorylation"], "type": "Family"}, "IPR011893": {"description": "Selenoprotein, Rdx-type", "go_ids": [], "go_terms": [], "name": "Selenoprotein_Rdx-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011894": {"description": "2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate", "go_ids": ["GO:0016625"], "go_terms": ["GO:0016625:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor:F"], "name": "PorC_KorC", "pathway_ids": ["PWY-6863", "PWY-6588", "PWY-8275", "PWY-5493", "PWY-5600", "PWY-6142", "PWY-8377", "PWY-6587", "PWY-5497", "PWY-6876", "PWY-8189", "PWY-8303", "PWY-5538", "PWY-5392", "PWY-6583", "PWY-5483"], "pathways": ["PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-6588:t:pyruvate fermentation to acetone", "PWY-8275:t:pyruvate decarboxylation to acetyl CoA III", "PWY-5493:t:reductive monocarboxylic acid cycle", "PWY-5600:t:pyruvate fermentation to acetate VII", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-6587:t:pyruvate fermentation to ethanol III", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-6876:t:isopropanol biosynthesis (engineered)", "PWY-8189:t:L-alanine degradation V (oxidative Stickland reaction)", "PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-5538:t:pyruvate fermentation to acetate VI", "PWY-5392:t:reductive TCA cycle II", "PWY-6583:t:pyruvate fermentation to butanol I", "PWY-5483:t:pyruvate fermentation to acetate III"], "type": "Domain"}, "IPR011895": {"description": "Pyruvate-flavodoxin oxidoreductase", "go_ids": ["GO:0005506", "GO:0016903", "GO:0022900"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016903:oxidoreductase activity, acting on the aldehyde or oxo group of donors:F", "GO:0022900:electron transport chain:P"], "name": "Pyrv_flavodox_OxRed", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011896": {"description": "2-oxoacid:acceptor oxidoreductase, beta subunit", "go_ids": [], "go_terms": [], "name": "OFOB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011897": {"description": "Translation elongation factor P-like, YeiP", "go_ids": [], "go_terms": [], "name": "Transl_elong_p-like_YeiP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011898": {"description": "2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate", "go_ids": ["GO:0016625", "GO:0051539"], "go_terms": ["GO:0016625:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "PorD_KorD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011899": {"description": "Glutaredoxin, eukaryotic/virial", "go_ids": [], "go_terms": [], "name": "Glutaredoxin_euk/vir", "pathway_ids": ["R-HSA-499943", "R-RNO-499943", "R-MMU-499943", "R-SSC-499943"], "pathways": ["R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SSC-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Domain"}, "IPR011900": {"description": "Glutaredoxin, GrxC", "go_ids": ["GO:0045454"], "go_terms": ["GO:0045454:cell redox homeostasis:P"], "name": "GRX_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011901": {"description": "Glutaredoxin-2", "go_ids": ["GO:0005829"], "go_terms": ["GO:0005829:cytosol:C"], "name": "Grx2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011902": {"description": "Glutaredoxin, GrxA", "go_ids": ["GO:0009055", "GO:0015035", "GO:0045454"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0015035:protein-disulfide reductase activity:F", "GO:0045454:cell redox homeostasis:P"], "name": "GRXA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011903": {"description": "Disulfide oxidoreductase TON_0319-like", "go_ids": [], "go_terms": [], "name": "TON_0319-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011904": {"description": "Acetate-CoA ligase", "go_ids": ["GO:0003987", "GO:0016208", "GO:0006085"], "go_terms": ["GO:0003987:acetyl-CoA synthetase activity:F", "GO:0016208:AMP binding:F", "GO:0006085:acetyl-CoA biosynthetic process:P"], "name": "Ac_CoA_lig", "pathway_ids": ["PWY-7857", "PWY-8328", "PWY-5133", "PWY-6672", "PWY-5108", "PWY-8303", "PWY-7118", "PWY-5132", "R-DDI-71384", "R-HSA-2151201", "R-DME-71384", "R-SCE-71384", "R-HSA-71384", "R-SPO-71384", "R-MMU-71384"], "pathways": ["PWY-7857:t:adlupulone and adhumulone biosynthesis", "PWY-8328:t:acetate and ATP formation from acetyl-CoA III", "PWY-5133:t:colupulone and cohumulone biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-5108:t:L-isoleucine biosynthesis V", "PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-7118:t:chitin deacetylation", "PWY-5132:t:lupulone and humulone biosynthesis", "R-DDI-71384:r:Ethanol oxidation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-71384:r:Ethanol oxidation", "R-SCE-71384:r:Ethanol oxidation", "R-HSA-71384:r:Ethanol oxidation", "R-SPO-71384:r:Ethanol oxidation", "R-MMU-71384:r:Ethanol oxidation"], "type": "Family"}, "IPR011905": {"description": "Glutaredoxin-like, plant II", "go_ids": [], "go_terms": [], "name": "GlrX-like_pln_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011906": {"description": "Glutaredoxin domain", "go_ids": [], "go_terms": [], "name": "Glutaredoxin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011907": {"description": "Ribonuclease III", "go_ids": ["GO:0003723", "GO:0004525", "GO:0006364"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0004525:ribonuclease III activity:F", "GO:0006364:rRNA processing:P"], "name": "RNase_III", "pathway_ids": ["R-CEL-426486", "R-MMU-426486", "R-MMU-203927", "R-HSA-203927", "R-CEL-203927"], "pathways": ["R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Family"}, "IPR011908": {"description": "Lipopolysaccharide heptosyltransferase I", "go_ids": ["GO:0009244", "GO:0008920"], "go_terms": ["GO:0009244:lipopolysaccharide core region biosynthetic process:P", "GO:0008920:lipopolysaccharide heptosyltransferase activity:F"], "name": "LipoPS_heptosylTferase-I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011909": {"description": "Glutaredoxin-like protein NrdH", "go_ids": ["GO:0045454"], "go_terms": ["GO:0045454:cell redox homeostasis:P"], "name": "GlrX_NrdH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011910": {"description": "ADP-heptose--LPS heptosyltransferase 2", "go_ids": ["GO:0009103", "GO:0016757"], "go_terms": ["GO:0009103:lipopolysaccharide biosynthetic process:P", "GO:0016757:glycosyltransferase activity:F"], "name": "RfaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011911": {"description": "Glutaredoxin-like protein, YruB", "go_ids": [], "go_terms": [], "name": "GlrX_YruB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011912": {"description": "ADP-L-glycero-D-manno-heptose-6-epimerase", "go_ids": ["GO:0005975", "GO:0008712", "GO:0050661"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0008712:ADP-glyceromanno-heptose 6-epimerase activity:F", "GO:0050661:NADP binding:F"], "name": "Heptose_epim", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011913": {"description": "RfaE bifunctional protein, domain I", "go_ids": ["GO:0005975", "GO:0016773", "GO:0016779"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016773:phosphotransferase activity, alcohol group as acceptor:F", "GO:0016779:nucleotidyltransferase activity:F"], "name": "RfaE_dom_I", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011914": {"description": "RfaE bifunctional protein, domain II", "go_ids": ["GO:0005975", "GO:0016773", "GO:0016779"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016773:phosphotransferase activity, alcohol group as acceptor:F", "GO:0016779:nucleotidyltransferase activity:F"], "name": "RfaE_dom_II", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011915": {"description": "Glutaredoxin-like protein, actinobacteria", "go_ids": [], "go_terms": [], "name": "GlrX_actino", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011916": {"description": "Lipopolysaccharide heptosyltransferase III, putative", "go_ids": [], "go_terms": [], "name": "LipoPS_heptosylTferase-III", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011917": {"description": "ABC transporter, lipid A-core flippase, MsbA", "go_ids": ["GO:0005524", "GO:0016020", "GO:0034040"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016020:membrane:C", "GO:0034040:ATPase-coupled lipid transmembrane transporter activity:F"], "name": "ABC_transpr_lipidA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011918": {"description": "ABC transporter, 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"GO:0016020"], "go_terms": ["GO:0008360:regulation of cell shape:P", "GO:0016020:membrane:C"], "name": "RodA/MrdB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011924": {"description": "Lipoprotein releasing system, ATP-binding protein", "go_ids": ["GO:0005524", "GO:0016020", "GO:0044873"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016020:membrane:C", "GO:0044873:lipoprotein localization to membrane:P"], "name": "LolD_lipo_ATP-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011925": {"description": "Lipoprotein-releasing system transmembrane protein LolC/E", "go_ids": ["GO:0016020", "GO:0042953"], "go_terms": ["GO:0016020:membrane:C", "GO:0042953:lipoprotein transport:P"], "name": "LolCE_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011926": {"description": "Lipoprotein-releasing system transmembrane protein LolE, gammaproteobacteria type", "go_ids": ["GO:0016020", "GO:0044874", "GO:0042953"], "go_terms": ["GO:0016020:membrane:C", "GO:0044874:lipoprotein localization to outer membrane:P", "GO:0042953:lipoprotein transport:P"], "name": "LolE_gammaproteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011927": {"description": "Stage V sporulation protein D", "go_ids": [], "go_terms": [], "name": "SpoVD_pbp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011928": {"description": "Bacteriophage phiJL001, Gp84", "go_ids": [], "go_terms": [], "name": "Phage_phiJL001_Gp84", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011929": {"description": "NlpC/P60 family, putative phage cell wall peptidase", "go_ids": [], "go_terms": [], "name": "Phage_pept_NlpC/P60", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011930": {"description": "Cell division protein FtsN", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "FtsN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011931": {"description": "Tyrosine recombinase XerC", "go_ids": ["GO:0003677", "GO:0006310", "GO:0007059", "GO:0015074", "GO:0051301"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006310:DNA recombination:P", "GO:0007059:chromosome segregation:P", "GO:0015074:DNA integration:P", "GO:0051301:cell division:P"], "name": "Recomb_XerC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011932": {"description": "Tyrosine recombinase XerD", "go_ids": ["GO:0006310", "GO:0009009"], "go_terms": ["GO:0006310:DNA recombination:P", "GO:0009009:site-specific recombinase activity:F"], "name": "Recomb_XerD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011933": {"description": "Double transmembrane domain", "go_ids": [], "go_terms": [], "name": "Double_TM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011935": {"description": "Conserved hypothetical protein CHP02231", "go_ids": [], "go_terms": [], "name": "CHP02231", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011936": {"description": "Myxococcus cysteine-rich 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"GO:0005524:ATP binding:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0008094:ATP-dependent activity, acting on DNA:F"], "name": "DNA_recomb/repair_RadA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011939": {"description": "DNA repair and recombination protein RadB", "go_ids": ["GO:0003684", "GO:0005524", "GO:0006281", "GO:0006310"], "go_terms": ["GO:0003684:damaged DNA binding:F", "GO:0005524:ATP binding:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P"], "name": "DNA_repair_and_recomb_RadB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011940": {"description": "Meiotic recombination protein Dmc1", "go_ids": ["GO:0003677", "GO:0005634", "GO:0007131", "GO:0000150"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0007131:reciprocal meiotic recombination:P", "GO:0000150:DNA strand exchange activity:F"], "name": "Dmc1", "pathway_ids": ["R-MMU-912446", "R-HSA-912446"], "pathways": ["R-MMU-912446:r:Meiotic recombination", "R-HSA-912446:r:Meiotic recombination"], "type": "Family"}, "IPR011941": {"description": "DNA recombination/repair protein Rad51", "go_ids": ["GO:0008094", "GO:0000724", "GO:0000150", "GO:0003697", "GO:0003690", "GO:1990426"], "go_terms": ["GO:0008094:ATP-dependent activity, acting on DNA:F", "GO:0000724:double-strand break repair via homologous recombination:P", "GO:0000150:DNA strand exchange activity:F", "GO:0003697:single-stranded DNA binding:F", "GO:0003690:double-stranded DNA binding:F", "GO:1990426:mitotic recombination-dependent replication fork processing:P"], "name": "DNA_recomb/repair_Rad51", "pathway_ids": ["PWY-7250", "R-GGA-912446", "R-GGA-5685938", "R-HSA-5685942", "R-GGA-5685942", "R-HSA-5693616", "R-BTA-5685938", "R-HSA-9704646", "R-GGA-351433", "R-GGA-5693616", "R-GGA-265976", "R-MMU-5693616", "R-HSA-8953750", "R-DME-5693616", "R-MMU-5685938", "R-BTA-912446", "R-CFA-5693568", "R-HSA-9709570", "R-HSA-912446", "R-BTA-5693616", 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II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes"], "type": "Domain"}, "IPR011948": {"description": "Dullard phosphatase domain, eukaryotic", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "Dullard_phosphatase", "pathway_ids": ["R-HSA-381038", "R-HSA-4419969", "R-BTA-4419969", "R-CEL-4419969", "R-SPO-4419969", "R-MMU-4419969", "R-DRE-4419969", "R-RNO-4419969", "R-XTR-4419969", "R-DME-4419969"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-DRE-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina"], "type": "Domain"}, "IPR011949": {"description": "HAD-superfamily hydrolase, subfamily IA, REG-2-like", "go_ids": [], "go_terms": [], "name": "HAD-SF_hydro_IA_REG-2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011950": {"description": "HAD-superfamily hydrolase, subfamily IA, CTE7", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "HAD-SF_hydro_IA_CTE7", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664", "R-MMU-4085001", "R-HSA-4085001", "R-RNO-4085001"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "R-MMU-4085001:r:Sialic acid metabolism", "R-HSA-4085001:r:Sialic acid metabolism", "R-RNO-4085001:r:Sialic acid metabolism"], "type": "Family"}, "IPR011951": {"description": "HAD-superfamily hydrolase, subfamily IA, YjjG/PynA", "go_ids": ["GO:0008253"], "go_terms": ["GO:0008253:5'-nucleotidase activity:F"], "name": "HAD-SF_hydro_IA_YjjG/PynA", "pathway_ids": ["PWY-7821", "PWY-7185", "PWY-5381", "PWY-6596", "PWY-5695", "PWY-6607", "PWY-6608", "PWY-6606"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-5381:t:NAD salvage (plants)", "PWY-6596:t:adenosine nucleotides degradation I", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II"], "type": "Family"}, "IPR011952": {"description": "CD-NTase-associated protein 3", "go_ids": [], "go_terms": [], "name": "CAP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011953": {"description": "Cobaltochelatase, CobN subunit", "go_ids": ["GO:0009236", "GO:0051116"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P", "GO:0051116:cobaltochelatase activity:F"], "name": "Cobalto_CobN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011954": {"description": "Benzoyl-CoA reductase, subunit A", "go_ids": ["GO:0018522"], "go_terms": ["GO:0018522:benzoyl-CoA reductase activity:F"], "name": "Benzoyl_CoA_Rdtase_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011955": {"description": "Benzoyl-CoA reductase, subunit B", "go_ids": [], "go_terms": [], "name": "Benzoyl_CoA_Rdtase_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011956": {"description": "Benzoyl-CoA reductase, subunit D", "go_ids": [], "go_terms": [], "name": "Benzoyl_CoA_Rdtase_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011957": {"description": "Benzoate-CoA ligase family", "go_ids": ["GO:0005524", "GO:0016405"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016405:CoA-ligase activity:F"], "name": "Benz_CoA_lig", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011958": {"description": "Benzoyl-CoA reductase, subunit C", "go_ids": [], "go_terms": [], "name": "Benzoyl_CoA_Rdtase_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011959": {"description": "Conserved hypothetical protein CHP02270", "go_ids": [], "go_terms": [], "name": "CHP02270", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011960": {"description": "Gentisate 1,2 dioxygenase 1", "go_ids": ["GO:0047922"], "go_terms": ["GO:0047922:gentisate 1,2-dioxygenase activity:F"], "name": "Gentisate_dOase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011961": {"description": "Ribosome maturation factor RimM", "go_ids": ["GO:0005840", "GO:0006364", "GO:0043022"], "go_terms": ["GO:0005840:ribosome:C", "GO:0006364:rRNA processing:P", "GO:0043022:ribosome binding:F"], "name": "RimM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011962": {"description": "dCTP deaminase", "go_ids": ["GO:0006229", "GO:0008829"], "go_terms": ["GO:0006229:dUTP biosynthetic process:P", "GO:0008829:dCTP deaminase activity:F"], "name": "dCTP_deaminase", "pathway_ids": ["PWY-7187"], "pathways": ["PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II"], "type": "Family"}, "IPR011963": {"description": "2,3-dihydroxybenzoate-AMP ligase", "go_ids": ["GO:0008668", "GO:0019290"], "go_terms": ["GO:0008668:2,3-dihydroxybenzoate--[aryl-carrier protein] ligase activity:F", "GO:0019290:siderophore biosynthetic process:P"], "name": "DHB_AMP_lig", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011964": {"description": "YVTN beta-propeller repeat", "go_ids": [], "go_terms": [], "name": "YVTN_b-propeller_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR011965": {"description": "Phenylacetic acid degradation operon negative regulatory protein PaaX", "go_ids": ["GO:0006351"], "go_terms": ["GO:0006351:DNA-templated transcription:P"], "name": "PaaX_trns_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011966": {"description": "Phenylacetic acid degradation protein PaaN", "go_ids": [], "go_terms": [], "name": "PaaN-DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011967": {"description": "3-hydroxyadipyl-CoA dehydrogenase PaaH", "go_ids": ["GO:0010124", "GO:0008691"], "go_terms": ["GO:0010124:phenylacetate catabolic process:P", "GO:0008691:3-hydroxybutyryl-CoA dehydrogenase activity:F"], "name": "3-OHacyl-CoA_DH_PaaH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011968": {"description": "Phenylacetate degradation probable enoyl-CoA hydratase PaaB", "go_ids": ["GO:0010124"], "go_terms": ["GO:0010124:phenylacetate catabolic process:P"], "name": "PaaB1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011969": {"description": "Clan AA aspartic peptidase, C-terminal", "go_ids": [], "go_terms": [], "name": "Clan_AA_Asp_peptidase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011970": {"description": "Lytic murein transglycosylase", "go_ids": [], "go_terms": [], "name": "MltB_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011971": {"description": "Conserved hypothetical protein CHP02284", "go_ids": [], "go_terms": [], "name": "CHP02284", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011972": {"description": "Conserved hypothetical protein CHP02285", "go_ids": [], "go_terms": [], "name": "CHP02285", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011973": {"description": "Phenylacetic acid degradation protein PaaD", "go_ids": ["GO:0016790"], "go_terms": ["GO:0016790:thiolester hydrolase activity:F"], "name": "PaaD", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis"], "type": "Family"}, "IPR011974": {"description": "Phenylacetic acid degradation protein PaaY", "go_ids": [], "go_terms": [], "name": "PaaY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011975": {"description": "Phenylacetic acid degradation protein PaaN2", "go_ids": [], "go_terms": [], "name": "PaaN_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011976": {"description": "Peptidase M3B, oligoendopeptidase-related", "go_ids": [], "go_terms": [], "name": "Pept_M3B_oligopep-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011977": {"description": "Peptidase M3B, oligoendopeptidase-related clade 3", "go_ids": [], "go_terms": [], "name": "Pept_M3B_clade3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011978": {"description": "YgfB-like", "go_ids": [], "go_terms": [], "name": "YgfB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011979": {"description": "Antitoxin Xre", "go_ids": [], "go_terms": [], "name": "Antitox_Xre", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011980": {"description": "Metal-staphylopine-binding protein CntA-like", "go_ids": ["GO:0020037", "GO:0016151", "GO:0015675"], "go_terms": ["GO:0020037:heme binding:F", "GO:0016151:nickel cation binding:F", "GO:0015675:nickel cation transport:P"], "name": "CntA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011981": {"description": "3,4-dihydroxyphenylacetate 2,3-dioxygenase, Mn/Fe-type", "go_ids": [], "go_terms": [], "name": "DHPA_dOase_Mn/Fe", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011982": {"description": "4-hydroxyphenylacetate 3-monooxygenase, reductase component", "go_ids": ["GO:0016651", "GO:0042537", "GO:0051287"], "go_terms": ["GO:0016651:oxidoreductase activity, acting on NAD(P)H:F", "GO:0042537:benzene-containing compound metabolic process:P", "GO:0051287:NAD binding:F"], "name": "HPA_mOase_red", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011983": {"description": "4-hydroxyphenylacetate catabolism regulatory protein HpaA", "go_ids": [], "go_terms": [], "name": "HpaA_TReg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011984": {"description": "3,4-dihydroxyphenylacetate 2,3-dioxygenase", "go_ids": ["GO:0008687"], "go_terms": ["GO:0008687:3,4-dihydroxyphenylacetate 2,3-dioxygenase activity:F"], "name": "HPCD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011985": {"description": "5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase", "go_ids": ["GO:1901023", "GO:0018480"], "go_terms": ["GO:1901023:4-hydroxyphenylacetate catabolic process:P", "GO:0018480:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity:F"], "name": "DH_HpaE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR011986": {"description": "Extradiol ring-cleavage dioxygenase LigAB, LigA subunit", "go_ids": [], "go_terms": [], "name": "Xdiol_dOase_LigA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR011987": {"description": "ATPase, V1 complex, subunit H, C-terminal", "go_ids": ["GO:0000221", "GO:1902600"], "go_terms": ["GO:0000221:vacuolar proton-transporting V-type ATPase, V1 domain:C", "GO:1902600:proton transmembrane transport:P"], "name": "ATPase_V1-cplx_hsu_C", "pathway_ids": ["R-CEL-1222556", "R-MMU-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-HSA-9639288", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-SCE-1222556", "R-SCE-917977", "R-MMU-77387", "R-BTA-1222556", "R-DDI-9639288", "R-SCE-77387", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-HSA-167590", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-DDI-917977", "R-MMU-983712", "R-DDI-983712", "R-HSA-917977", "R-BTA-77387", "R-HSA-9636467", "R-BTA-9639288", "R-HSA-182218", "R-DME-9639288"], "pathways": ["R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-MMU-77387:r:Insulin receptor recycling", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-SCE-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-BTA-77387:r:Insulin receptor recycling", "R-HSA-9636467:r:Blockage of phagosome acidification", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR011988": {"description": "MHC class II-associated invariant chain, trimerisation", "go_ids": ["GO:0019882", "GO:0042289", "GO:0016020"], "go_terms": ["GO:0019882:antigen processing and presentation:P", "GO:0042289:MHC class II protein binding:F", "GO:0016020:membrane:C"], "name": "MHC_II-assoc_invariant_trimer", "pathway_ids": ["R-HSA-9925563", "R-RNO-2132295", "R-HSA-2132295", "R-RNO-202733", "R-MMU-202733", "R-MMU-2132295", "R-HSA-202733"], "pathways": ["R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-202733:r:Cell surface 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"R-SPO-179409", "R-MMU-9762292", "R-HSA-4641258", "R-RNO-6791226", "R-BTA-4641258", "R-SPO-9770562", "R-HSA-8939243", "R-HSA-4608870", "R-MMU-9013406", "R-DDI-141430", "R-RNO-9639288", "R-MMU-6798695", "R-SSC-9013148", "R-MMU-5610780", "R-SPO-198753", "R-HSA-1660517", "R-HSA-6809371", "R-DDI-6811558", "R-XTR-2467813", "R-HSA-5467348", "R-RNO-450520", "R-HSA-1221632", "R-MMU-6807878", "R-MMU-9954709", "R-DDI-75815", "R-RNO-5668599", "R-SPO-8964038", "R-HSA-2871837", "R-HSA-1222556", "R-RNO-1660516", "R-MMU-180024", "R-DME-166208", "R-DME-9013406", "R-HSA-5362768", "R-DDI-9954709", "R-RNO-8852276", "R-HSA-432722", "R-BTA-174178", "R-SCE-3371571", "R-HSA-380972", "R-HSA-5685938", "R-BTA-3769402", "R-HSA-2500257", "R-SCE-6807878", "R-BTA-983712", "R-DRE-2500257", "R-HSA-1660514", "R-HSA-9824585", "R-DME-201722", "R-BTA-8854050", "R-DRE-9013148", "R-HSA-983712", "R-CEL-4420097", "R-CEL-8849471", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-HSA-9664422", "R-DDI-1169092", "R-CEL-5218920", "R-DME-69273", "R-HSA-180910", "R-CEL-5632684", "R-HSA-5689880", "R-SPO-389357", "R-MMU-9013408", "R-HSA-73856", "R-HSA-9639288", "R-SCE-2995383", "R-RNO-111465", "R-SCE-6804757", "R-SPO-5668599", "R-HSA-192905", "R-SPO-1222556", "R-DME-1295596", "R-MMU-1655829", "R-DME-177504", "R-HSA-1234176", "R-RNO-5673000", "R-MMU-68867", "R-MMU-72163", "R-DME-209461", "R-RNO-5628897", "R-HSA-141444"], "pathways": ["R-SCE-202670:r:ERKs are inactivated", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-BTA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-917937:r:Iron uptake and transport", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-1632852:r:Macroautophagy", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-DDI-983712:r:Ion channel transport", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9636467:r:Blockage of phagosome acidification", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SSC-9762292:r:Regulation of CDH11 function", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-202670:r:ERKs are inactivated", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-917937:r:Iron uptake and transport", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-437239:r:Recycling pathway of L1", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-SSC-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DDI-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DRE-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-MMU-437239:r:Recycling pathway of L1", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-1632852:r:Macroautophagy", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-9907900:r:Proteasome assembly", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-354192:r:Integrin signaling", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-SSC-198753:r:ERK/MAPK targets", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-9762292:r:Regulation of CDH11 function", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-72187:r:mRNA 3'-end processing", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-9013407:r:RHOH GTPase cycle", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-9823730:r:Formation of definitive endoderm", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9796292:r:Formation of axial mesoderm", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-2470946:r:Cohesin Loading onto Chromatin", "R-DDI-193648:r:NRAGE signals death through JNK", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-8853884:r:Transcriptional Regulation by VENTX", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-CEL-4641258:r:Degradation of DVL", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-CEL-6809371:r:Formation of the cornified envelope", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-BTA-6805567:r:Keratinization", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-382556:r:ABC-family proteins mediated transport", "R-CEL-1632852:r:Macroautophagy", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-2871796:r:FCERI mediated MAPK activation", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-9764561:r:Regulation of CDH1 Function", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-77387:r:Insulin receptor recycling", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-XTR-68877:r:Mitotic Prometaphase", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-389356:r:Co-stimulation by CD28", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-8951664:r:Neddylation", "R-HSA-77387:r:Insulin receptor recycling", "R-MMU-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-69231:r:Cyclin D associated events in G1", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-RNO-6805567:r:Keratinization", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DDI-198753:r:ERK/MAPK targets", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-RNO-165159:r:MTOR signalling", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-77387:r:Insulin receptor recycling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-DME-4641257:r:Degradation of AXIN", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-202670:r:ERKs are inactivated", "R-DRE-201681:r:TCF dependent signaling in response to WNT", "R-HSA-389356:r:Co-stimulation by CD28", "R-DME-983712:r:Ion channel transport", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DME-165159:r:MTOR signalling", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-9824272:r:Somitogenesis", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-166208:r:mTORC1-mediated signalling", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-166208:r:mTORC1-mediated signalling", "R-MMU-429947:r:Deadenylation of mRNA", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-917937:r:Iron uptake and transport", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-983712:r:Ion channel transport", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9833576:r:CDH11 homotypic and heterotypic interactions", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DDI-8951664:r:Neddylation", "R-MMU-432142:r:Platelet sensitization by LDL", "R-MMU-8951664:r:Neddylation", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-5689603:r:UCH proteinases", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-SPO-5689603:r:UCH proteinases", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-209421:r:Transcription activation by ARM", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DME-525793:r:Myogenesis", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-8849473:r:PTK6 Expression", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-DME-216167:r:Nuclear CI is degraded", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9907900:r:Proteasome assembly", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-8964038:r:LDL clearance", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-165159:r:MTOR signalling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-HSA-202424:r:Downstream TCR signaling", "R-CEL-4641257:r:Degradation of AXIN", "R-SSC-5673000:r:RAF activation", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-SPO-437239:r:Recycling pathway of L1", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9833482:r:PKR-mediated signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-5673000:r:RAF activation", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-525793:r:Myogenesis", "R-SSC-9764561:r:Regulation of CDH1 Function", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-165159:r:MTOR signalling", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-8964038:r:LDL clearance", "R-CEL-69231:r:Cyclin D associated events in G1", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-77387:r:Insulin receptor recycling", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-4086400:r:PCP/CE pathway", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8951664:r:Neddylation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-68877:r:Mitotic Prometaphase", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-DME-389513:r:Co-inhibition by CTLA4", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-DRE-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-GGA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-77387:r:Insulin receptor recycling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-8951430:r:RUNX3 regulates WNT signaling", "R-SSC-9013026:r:RHOB GTPase cycle", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-BTA-429947:r:Deadenylation of mRNA", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-164944:r:Nef and signal transduction", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-SSC-418990:r:Adherens junctions interactions", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-432142:r:Platelet sensitization by LDL", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5467333:r:APC truncation mutants are not K63 polyubiquitinated", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-BTA-8951664:r:Neddylation", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-8951430:r:RUNX3 regulates WNT signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-4641258:r:Degradation of DVL", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-8964038:r:LDL clearance", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-6809371:r:Formation of the cornified envelope", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-198753:r:ERK/MAPK targets", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-525793:r:Myogenesis", "R-SCE-198753:r:ERK/MAPK targets", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-68877:r:Mitotic Prometaphase", "R-SSC-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-418990:r:Adherens junctions interactions", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-69481:r:G2/M Checkpoints", "R-SPO-917937:r:Iron uptake and transport", "R-CEL-4086398:r:Ca2+ pathway", "R-DME-8964038:r:LDL clearance", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-XTR-6807878:r:COPI-mediated anterograde transport", "R-BTA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-437239:r:Recycling pathway of L1", "R-MMU-5673000:r:RAF activation", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-DDI-4641258:r:Degradation of DVL", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-BTA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9762292:r:Regulation of CDH11 function", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DRE-9013026:r:RHOB GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-8980692:r:RHOA GTPase cycle", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-9833482:r:PKR-mediated signaling", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-109704:r:PI3K Cascade", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-8853884:r:Transcriptional Regulation by VENTX", "R-DME-9020702:r:Interleukin-1 signaling", "R-SSC-9013106:r:RHOC GTPase cycle", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-9833482:r:PKR-mediated signaling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-8964038:r:LDL clearance", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9764561:r:Regulation of CDH1 Function", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DRE-9013407:r:RHOH GTPase cycle", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-DME-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-4641257:r:Degradation of AXIN", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-5673000:r:RAF activation", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-432142:r:Platelet sensitization by LDL", "R-CEL-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-109704:r:PI3K Cascade", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-5689603:r:UCH proteinases", "R-DDI-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-525793:r:Myogenesis", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-209190:r:Phosphorylation of CI", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-DDI-202670:r:ERKs are inactivated", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-4086398:r:Ca2+ pathway", "R-CEL-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SSC-69231:r:Cyclin D associated events in G1", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-2467813:r:Separation of Sister Chromatids", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-389356:r:Co-stimulation by CD28", "R-HSA-429947:r:Deadenylation of mRNA", "R-DRE-9764561:r:Regulation of CDH1 Function", "R-HSA-9696264:r:RND3 GTPase cycle", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-8854214:r:TBC/RABGAPs", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-165159:r:MTOR signalling", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-983189:r:Kinesins", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-4641257:r:Degradation of AXIN", "R-DME-9907900:r:Proteasome assembly", "R-DDI-5689603:r:UCH proteinases", "R-RNO-9707616:r:Heme signaling", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-8951430:r:RUNX3 regulates WNT signaling", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-109704:r:PI3K Cascade", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-392517:r:Rap1 signalling", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-166208:r:mTORC1-mediated signalling", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8964038:r:LDL clearance", "R-SSC-180024:r:DARPP-32 events", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-DDI-5632684:r:Hedgehog 'on' state", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9013407:r:RHOH GTPase cycle", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-SSC-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-202670:r:ERKs are inactivated", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-BTA-9013106:r:RHOC GTPase cycle", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-CEL-201681:r:TCF dependent signaling in response to WNT", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-68877:r:Mitotic Prometaphase", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-RNO-166166:r:MyD88-independent TLR4 cascade", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-5689603:r:UCH proteinases", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-DME-9013407:r:RHOH GTPase cycle", "R-DME-8951430:r:RUNX3 regulates WNT signaling", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-BTA-9764561:r:Regulation of CDH1 Function", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-418990:r:Adherens junctions interactions", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9013026:r:RHOB GTPase cycle", "R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-DDI-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SSC-9833482:r:PKR-mediated signaling", "R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-HSA-202670:r:ERKs are inactivated", "R-DME-432524:r:Degradation of PER", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-1632852:r:Macroautophagy", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-DDI-437239:r:Recycling pathway of L1", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-162592:r:Integration of provirus", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-HSA-6805567:r:Keratinization", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DRE-6809371:r:Formation of the cornified envelope", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-BTA-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-SSC-6805567:r:Keratinization", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DME-9707616:r:Heme signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DRE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-165159:r:MTOR signalling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-DRE-4086398:r:Ca2+ pathway", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6809371:r:Formation of the cornified envelope", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-DME-9764561:r:Regulation of CDH1 Function", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-SPO-1632852:r:Macroautophagy", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-140342:r:Apoptosis induced DNA fragmentation", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-RNO-9762292:r:Regulation of CDH11 function", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-9764561:r:Regulation of CDH1 Function", "R-DME-5689603:r:UCH proteinases", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-4086398:r:Ca2+ pathway", "R-HSA-180024:r:DARPP-32 events", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-6809371:r:Formation of the cornified envelope", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-SCE-437239:r:Recycling pathway of L1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-HSA-983189:r:Kinesins", "R-RNO-9766229:r:Degradation of CDH1", "R-CEL-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-983712:r:Ion channel transport", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-68949:r:Orc1 removal from chromatin", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-69481:r:G2/M Checkpoints", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-525793:r:Myogenesis", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-1632852:r:Macroautophagy", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-5626467:r:RHO GTPases activate IQGAPs", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-SSC-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-198753:r:ERK/MAPK targets", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-5620924:r:Intraflagellar transport", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-SSC-432142:r:Platelet sensitization by LDL", "R-RNO-9013407:r:RHOH GTPase cycle", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DME-6809371:r:Formation of the cornified envelope", "R-RNO-180024:r:DARPP-32 events", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-DME-432620:r:Dephosphorylation of PER", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SPO-2871796:r:FCERI mediated MAPK activation", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-77387:r:Insulin receptor recycling", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-DME-209396:r:Phosphorylation of ARM", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-SSC-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SSC-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-917937:r:Iron uptake and transport", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-525793:r:Myogenesis", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-6805567:r:Keratinization", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-8854214:r:TBC/RABGAPs", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-DME-9035034:r:RHOF GTPase cycle", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-GGA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-9013106:r:RHOC GTPase cycle", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-BTA-418990:r:Adherens junctions interactions", "R-DME-8980692:r:RHOA GTPase cycle", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-DME-69473:r:G2/M DNA damage checkpoint", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-69231:r:Cyclin D associated events in G1", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-389356:r:Co-stimulation by CD28", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-418990:r:Adherens junctions interactions", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-350562:r:Regulation of ornithine 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MAD2 inhibitory signal", "R-DME-68949:r:Orc1 removal from chromatin", "R-SSC-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-5689880:r:Ub-specific processing proteases", "R-RNO-6809371:r:Formation of the cornified envelope", "R-DDI-171007:r:p38MAPK events", "R-SSC-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-909733:r:Interferon alpha/beta signaling", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DRE-6791226:r:Major 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WNT", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-9707616:r:Heme signaling", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-DRE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SPO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-77387:r:Insulin receptor recycling", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-4086398:r:Ca2+ pathway", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-8964038:r:LDL clearance", "R-RNO-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-202670:r:ERKs are inactivated", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9707616:r:Heme signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-209407:r:Transport of ARM to the nucleus", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-198753:r:ERK/MAPK targets", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-201681:r:TCF dependent signaling 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"R-DRE-72695", "R-MMU-5578775", "R-HSA-8950505", "R-RNO-9931269", "R-HSA-9755511", "R-HSA-9648025", "R-CEL-8866427", "R-MMU-674695", "R-MMU-9018519", "R-HSA-3301854", "R-HSA-9013149", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-8866427", "R-XTR-5668541", "R-MMU-9931269", "R-SPO-9013424", "R-DDI-68949", "R-HSA-8948751", "R-HSA-9613829", "R-MMU-6804115", "R-MMU-5620922", "R-MMU-5389840", "R-GGA-72695", "R-BTA-8939902", "R-BTA-9766229", "R-HSA-8853884", "R-CEL-5620922", "R-HSA-187577", "R-SPO-176408", "R-RNO-8943724", "R-RNO-3371453", "R-DDI-9755511", "R-DME-8957275", "R-DME-77595", "R-DME-156827", "R-HSA-901032", "R-SPO-2559580", "R-HSA-76066", "R-RNO-9603798", "R-CEL-437239", "R-MMU-69601", "R-DME-983189", "R-MMU-380972", "R-SCE-5693565", "R-SCE-975957", "R-HSA-3214841", "R-DRE-8852276", "R-RNO-8957275", "R-RNO-190873", "R-XTR-4641257", "R-MMU-8854050", "R-DME-8856828", "R-SCE-1257604", "R-HSA-5578775", "R-MMU-5689603", "R-RNO-5099900", "R-MMU-9648025", "R-SPO-1257604", "R-HSA-5607764", "R-XTR-72695", "R-DRE-5419276", "R-GGA-429947", "R-DRE-5687128", "R-RNO-4608870", "R-RNO-6811434", "R-BTA-9664873", "R-CEL-196025", "R-BTA-174048", "R-BTA-9603798", "R-RNO-6782135", "R-HSA-6807878", "R-DRE-975957", "R-SPO-8856828", "R-BTA-6804760", "R-RNO-204005", "R-MMU-176407", "R-HSA-5213460", "R-SCE-9907900", "R-HSA-5668541", "R-HSA-5687128", "R-DRE-3214841", "R-MMU-177504", "R-XTR-195253", "R-MMU-166208", "R-DDI-174178", "R-HSA-9696273", "R-XTR-1169091"], "pathways": ["R-RNO-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DRE-4641258:r:Degradation of DVL", "R-XTR-69481:r:G2/M Checkpoints", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-5625970:r:RHO GTPases activate KTN1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-163282:r:Mitochondrial transcription initiation", "R-HSA-8951664:r:Neddylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-XTR-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-XTR-5610787:r:Hedgehog 'off' state", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-XTR-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-9696273:r:RND1 GTPase cycle", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-165159:r:MTOR signalling", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-XTR-4608870:r:Asymmetric localization of PCP proteins", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-DDI-844456:r:The NLRP3 inflammasome", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-DDI-6811438:r:Intra-Golgi traffic", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-8964038:r:LDL clearance", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-165159:r:MTOR signalling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-DME-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-XTR-6799198:r:Complex I biogenesis", "R-DDI-437239:r:Recycling pathway of L1", "R-DME-72649:r:Translation initiation complex formation", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9824272:r:Somitogenesis", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-166208:r:mTORC1-mediated signalling", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9865881:r:Complex III assembly", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-166208:r:mTORC1-mediated signalling", "R-MMU-429947:r:Deadenylation of mRNA", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2470946:r:Cohesin Loading onto Chromatin", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6811438:r:Intra-Golgi traffic", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5625970:r:RHO GTPases activate KTN1", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-5419276:r:Mitochondrial translation termination", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6798695:r:Neutrophil degranulation", "R-XTR-8948751:r:Regulation of PTEN stability and activity", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-9664873:r:Pexophagy", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-8951664:r:Neddylation", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-8951664:r:Neddylation", "R-BTA-9033241:r:Peroxisomal protein import", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-8939211:r:ESR-mediated signaling", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-XTR-5689880:r:Ub-specific processing proteases", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-165159:r:MTOR signalling", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-844456:r:The NLRP3 inflammasome", "R-XTR-6798695:r:Neutrophil degranulation", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1632852:r:Macroautophagy", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-XTR-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-6785470:r:tRNA processing in the mitochondrion", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-5620924:r:Intraflagellar transport", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-844456:r:The NLRP3 inflammasome", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-XTR-5632684:r:Hedgehog 'on' state", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-XTR-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-6787450:r:tRNA modification in the mitochondrion", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-RNO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9013424:r:RHOV GTPase cycle", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-9013420:r:RHOU GTPase cycle", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-RNO-9907900:r:Proteasome assembly", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DME-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-8964038:r:LDL clearance", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-SCE-437239:r:Recycling pathway of L1", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-983189:r:Kinesins", "R-HSA-165159:r:MTOR signalling", "R-BTA-9020702:r:Interleukin-1 signaling", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-68867:r:Assembly of the pre-replicative complex", "R-XTR-5620924:r:Intraflagellar transport", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-8939211:r:ESR-mediated signaling", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-XTR-5689603:r:UCH proteinases", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-SPO-437239:r:Recycling pathway of L1", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9833482:r:PKR-mediated signaling", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-9020702:r:Interleukin-1 signaling", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-69481:r:G2/M Checkpoints", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-3214841:r:PKMTs methylate histone lysines", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-1632852:r:Macroautophagy", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-9033241:r:Peroxisomal protein import", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-DRE-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-8964038:r:LDL clearance", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-9033241:r:Peroxisomal protein import", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-DRE-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-5620924:r:Intraflagellar transport", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-196025:r:Formation of annular gap junctions", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-72649:r:Translation initiation complex formation", "R-MMU-9646399:r:Aggrephagy", "R-RNO-8951664:r:Neddylation", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SCE-196025:r:Formation of annular gap junctions", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-SPO-196025:r:Formation of annular gap junctions", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-9664873:r:Pexophagy", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DRE-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2672351:r:Stimuli-sensing channels", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-XTR-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-9615710:r:Late endosomal microautophagy", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-2132295:r:MHC class II antigen presentation", "R-MMU-191859:r:snRNP Assembly", "R-XTR-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-3214842:r:HDMs demethylate histones", "R-DRE-9865881:r:Complex III assembly", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-SCE-8939211:r:ESR-mediated signaling", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-3214847:r:HATs acetylate histones", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-9733709:r:Cardiogenesis", "R-SCE-6811438:r:Intra-Golgi traffic", "R-CEL-9013420:r:RHOU GTPase cycle", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-SCE-190873:r:Gap junction degradation", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-9013420:r:RHOU GTPase cycle", "R-XTR-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-8939211:r:ESR-mediated signaling", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5632684:r:Hedgehog 'on' state", "R-DME-8951664:r:Neddylation", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DRE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-DME-6811438:r:Intra-Golgi traffic", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-RNO-9013424:r:RHOV GTPase cycle", "R-BTA-429947:r:Deadenylation of mRNA", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-9696273:r:RND1 GTPase cycle", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-9907900:r:Proteasome assembly", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-9865881:r:Complex III assembly", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-DRE-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-CEL-983189:r:Kinesins", "R-SPO-6811438:r:Intra-Golgi traffic", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-XTR-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-XTR-9907900:r:Proteasome assembly", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5689603:r:UCH proteinases", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-RNO-3371568:r:Attenuation phase", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DRE-69481:r:G2/M Checkpoints", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-8964038:r:LDL clearance", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling", "R-DME-9865881:r:Complex III assembly", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DRE-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-844456:r:The NLRP3 inflammasome", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-418594:r:G alpha (i) signalling events", "R-XTR-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-RNO-9865881:r:Complex III assembly", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-RNO-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-DME-190873:r:Gap junction degradation", "R-MMU-6811438:r:Intra-Golgi traffic", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-CEL-8939211:r:ESR-mediated signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-8964038:r:LDL clearance", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-3371568:r:Attenuation phase", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-4641258:r:Degradation of DVL", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-4641257:r:Degradation of AXIN", "R-DME-5389840:r:Mitochondrial translation elongation", "R-RNO-5620924:r:Intraflagellar transport", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-191859:r:snRNP Assembly", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-190873:r:Gap junction degradation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DRE-4641257:r:Degradation of AXIN", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9907900:r:Proteasome assembly", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-8964038:r:LDL clearance", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-3371568:r:Attenuation phase", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-196025:r:Formation of annular gap junctions", "R-DDI-9833482:r:PKR-mediated signaling", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-3214847:r:HATs acetylate histones", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-DDI-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-844456:r:The NLRP3 inflammasome", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-XTR-68949:r:Orc1 removal from chromatin", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-9664873:r:Pexophagy", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-8939211:r:ESR-mediated signaling", "R-XTR-8941858:r:Regulation of RUNX3 expression and activity", "R-SCE-844456:r:The NLRP3 inflammasome", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-180746:r:Nuclear import of Rev protein", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-9833482:r:PKR-mediated signaling", "R-XTR-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-XTR-9766229:r:Degradation of CDH1", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-163282:r:Mitochondrial transcription initiation", "R-RNO-8964038:r:LDL clearance", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371571:r:HSF1-dependent transactivation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-XTR-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-XTR-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-437239:r:Recycling pathway of L1", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-9907900:r:Proteasome assembly", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-4641258:r:Degradation of DVL", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SPO-9770562:r:mRNA Polyadenylation", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-4641257:r:Degradation of AXIN", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-XTR-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-CEL-190873:r:Gap junction degradation", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-2672351:r:Stimuli-sensing channels", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-SPO-8964038:r:LDL clearance", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-166208:r:mTORC1-mediated signalling", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-9907900:r:Proteasome assembly", "R-DRE-68949:r:Orc1 removal from chromatin", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-SCE-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-XTR-5358346:r:Hedgehog ligand biogenesis", "R-DRE-72649:r:Translation initiation complex formation", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-9755511:r:KEAP1-NFE2L2 pathway", "R-XTR-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9931953:r:Biofilm formation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8868766:r:rRNA processing in the mitochondrion", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-5610787:r:Hedgehog 'off' state", "R-XTR-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-XTR-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-9013420:r:RHOU GTPase cycle", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-DRE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-GGA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-4641258:r:Degradation of DVL", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-176412:r:Phosphorylation of the APC/C", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-429947:r:Deadenylation of mRNA", "R-DRE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-196025:r:Formation of annular gap junctions", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-XTR-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-5689603:r:UCH proteinases", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-3371568:r:Attenuation phase", "R-DRE-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-190873:r:Gap junction degradation", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-DME-1632852:r:Macroautophagy", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DRE-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-6811438:r:Intra-Golgi traffic", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-983189:r:Kinesins", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-MMU-9664873:r:Pexophagy", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-4641257:r:Degradation of AXIN", "R-MMU-190873:r:Gap junction degradation", "R-CEL-5610787:r:Hedgehog 'off' state", 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"R-MMU-112043", "R-MMU-380259", "R-HSA-111997", "R-HSA-3000171", "R-SCE-193648", "R-HSA-9948001", "R-BTA-500657", "R-HSA-72163", "R-CEL-112043", "R-DME-112043", "R-DDI-5696394", "R-RNO-5654228", "R-DRE-381426", "R-MMU-2025928", "R-DRE-8980692", "R-MMU-3108214", "R-RNO-9013420", "R-HSA-9609736", "R-DDI-9013418", "R-RNO-2871796", "R-MMU-70221", "R-SSC-114508", "R-SSC-6798695", "R-HSA-1059683", "R-BTA-5620916", "R-HSA-202433", "R-HSA-201451", "R-DME-111932", "R-DME-111933", "R-DME-1483166", "R-RNO-9860927", "R-MMU-9034793", "R-HSA-114608", "R-PFA-8847453", "R-XTR-5673001", "R-HSA-500657", "R-HSA-9022535", "R-MMU-2672351", "R-RNO-354192", "R-HSA-9013148", "R-RNO-8856828", "R-RNO-75205", "R-MMU-5621480", "R-RNO-434316", "R-HSA-113501", "R-MMU-2173789", "R-HSA-9696270", "R-DME-6798695", "R-HSA-5654726", "R-BTA-5696394", "R-MMU-9013424", "R-RNO-3928664", "R-MMU-1474151", "R-SSC-879415", "R-HSA-9009391", "R-HSA-9717207", "R-HSA-9027277", "R-MMU-9696273", "R-HSA-9725370", "R-SPO-202433", "R-HSA-5668599", "R-HSA-8849469", "R-MMU-416476", "R-HSA-6798695", "R-HSA-2151201", "R-DME-425561", "R-CEL-5626467", "R-RNO-5576894", "R-CEL-6798695", "R-HSA-69273", "R-CEL-9619229", "R-BTA-6798695", "R-SSC-1474228", "R-SPO-1855204", "R-SPO-5696395", "R-MMU-445989", "R-CEL-451308", "R-CEL-381426", "R-DME-9856872", "R-MMU-2029485", "R-HSA-9013408", "R-MMU-434316", "R-HSA-5654221", "R-HSA-901042", "R-MMU-1474228", "R-HSA-3928664", "R-HSA-8963693", "R-DRE-1482925", "R-CFA-2514859", "R-HSA-5673001", "R-RNO-381426", "R-HSA-204005", "R-BTA-445355", "R-MMU-418217", "R-MMU-6809371", "R-DME-446388", "R-MMU-445095", "R-BTA-933542", "R-DDI-5627123", "R-MMU-8854518", "R-BTA-9646399", "R-CEL-9013425", "R-RNO-933542", "R-CEL-209968", "R-SPO-6798695", "R-DME-381426", "R-HSA-9617324", "R-RNO-209968", "R-HSA-445355", "R-SPO-9013419", "R-CEL-1483166", "R-HSA-2160916", "R-RNO-5654221", "R-HSA-5654227", "R-HSA-1483191", "R-CFA-209968", "R-RNO-4086398", "R-DRE-9013148", "R-MMU-1059683", "R-HSA-3928663", "R-HSA-5627123", "R-CEL-5578775", "R-HSA-438066", "R-RNO-5607764", "R-MMU-416482", "R-BTA-451308", "R-PFA-6798695", "R-RNO-1855204", "R-MMU-5654733", "R-RNO-9856872", "R-HSA-8957275", "R-CEL-2514859", "R-BTA-2025928", "R-HSA-380259", "R-CEL-5218920", "R-RNO-445095", "R-BTA-112043", "R-HSA-3000178", "R-RNO-1474228", "R-HSA-5689880", "R-MMU-4086398", "R-MMU-8949215", "R-HSA-1489509", "R-RNO-9009391", "R-MMU-210990", "R-DDI-416476", "R-MMU-9013408", "R-DDI-114608", "R-DME-445355", "R-HSA-442982", "R-RNO-425561", "R-BTA-8957275", "R-HSA-5673000", "R-HSA-5218920", "R-MMU-9013420", "R-HSA-8853659", "R-RNO-983231", "R-HSA-442720", "R-MMU-1482788", "R-MMU-163560", "R-HSA-8949664", "R-MMU-5620912", "R-HSA-446107", "R-MMU-5673001", "R-PFA-6811555", "R-RNO-212718", "R-RNO-5673000", "R-DME-442729", "R-HSA-9026527", "R-HSA-434316", "R-HSA-182971", "R-HSA-2424491", "R-HSA-111447", "R-BTA-5607763", "R-SPO-5696394", "R-HSA-416482", "R-CEL-442729", "R-SPO-9013148", "R-HSA-5637810", "R-CEL-9648002", "R-HSA-9696264", "R-DME-8876725", "R-RNO-163560", "R-MMU-1483166", "R-PFA-4420097", "R-RNO-70221", "R-HSA-2022090", "R-RNO-879415", "R-SPO-5627123", "R-HSA-1445148", "R-CEL-5696395", "R-HSA-111933", "R-HSA-5696394", "R-MMU-193648", "R-DDI-8963693", "R-MMU-5627123", "R-DDI-202433", "R-MMU-69273", "R-MMU-9768727", "R-HSA-9664323", "R-XTR-8957275", "R-MMU-9860927", "R-DRE-9013419", "R-HSA-5655253", "R-HSA-5625900", "R-HSA-416572", "R-HSA-3000497", "R-HSA-5607763", "R-DME-5673001", "R-HSA-9694548", "R-PFA-5687128", "R-MMU-8980692", "R-RNO-1169408", "R-SCE-6798695", "R-HSA-2029485", "R-DME-9013425", "R-DME-114508", "R-RNO-399997", "R-HSA-9013423", "R-RNO-445355", "R-RNO-2025928", "R-MMU-163615", "R-DME-416476", "R-SPO-9013420", "R-CEL-111932", "R-HSA-4086398", "R-HSA-111932", "R-RNO-451308", "R-SSC-9860927", "R-DRE-8957275", "R-HSA-418359", "R-HSA-381038", "R-HSA-5655291", "R-CEL-163560", "R-DME-936837", "R-BTA-3928664", "R-MMU-113501", "R-HSA-936837", "R-HSA-380270", "R-DDI-2514859", "R-RNO-936837", "R-RNO-9856530", "R-XTR-354192", "R-PFA-1660499", "R-MMU-212718", "R-HSA-5654219", "R-HSA-201556", "R-SSC-3000497", "R-HSA-446388", "R-CEL-2871809", "R-BTA-9856530", "R-SCE-2514859", "R-HSA-8875360", "R-CEL-9856530", "R-SPO-6807878", "R-RNO-5627123", "R-MMU-5607764", "R-GGA-3000471", "R-DDI-9646399", "R-CEL-438066", "R-MMU-446388", "R-RNO-3000471", "R-BTA-380259", "R-BTA-9035034", "R-HSA-380320", "R-SSC-9856530", "R-RNO-392517", "R-SCE-5607764", "R-BTA-2871809", "R-HSA-9649948", "R-HSA-6799990", "R-CEL-114508", "R-MMU-5668599", "R-XTR-1169092", "R-SCE-9013420", "R-RNO-9013406", "R-HSA-5621480", "R-XTR-392517", "R-HSA-5655302", "R-HSA-75205", "R-CEL-936837", "R-HSA-381426", "R-CEL-203615", "R-DME-438066", "R-HSA-2173789", "R-DME-1482925", "R-RNO-201556", "R-HSA-70221", "R-HSA-9665686", "R-SPO-5607764", "R-RNO-8853659", "R-MMU-166016", "R-MMU-438066", "R-MMU-5578775", "R-HSA-8950505", "R-MMU-2160916", "R-GGA-9013418", "R-MMU-111933", "R-BTA-416476", "R-SSC-390522", "R-BTA-1855204", "R-DME-350416", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9913351", "R-SPO-9013424", "R-RNO-445989", "R-RNO-111957", "R-HSA-418890", "R-HSA-9613829", "R-CEL-8949664", "R-MMU-375165", "R-CEL-375165", "R-HSA-9683686", "R-HSA-8876725", "R-MMU-1169092", "R-SCE-202433", "R-DME-8957275", "R-DME-2514859", "R-BTA-879415", "R-SSC-114608", "R-HSA-9619665", "R-MMU-203615", "R-MMU-9619229"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-MMU-9648002:r:RAS processing", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-CEL-416476:r:G alpha (q) signalling events", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-114608:r:Platelet degranulation", "R-CEL-9646399:r:Aggrephagy", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-9856872:r:Malate-aspartate shuttle", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-163615:r:PKA activation", "R-RNO-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-201451:r:Signaling by BMP", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-180024:r:DARPP-32 events", "R-DME-4086398:r:Ca2+ pathway", "R-BTA-8949215:r:Mitochondrial calcium ion transport", "R-RNO-390522:r:Striated Muscle Contraction", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-RNO-5578775:r:Ion homeostasis", "R-GGA-75205:r:Dissolution of Fibrin Clot", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-1169092:r:Activation of RAS in B cells", "R-DRE-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-2424491:r:DAP12 signaling", "R-GGA-390522:r:Striated Muscle Contraction", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-390522:r:Striated Muscle Contraction", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-111957:r:Cam-PDE 1 activation", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-CEL-3928664:r:Ephrin signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-1483191:r:Synthesis of PC", "R-HSA-167021:r:PLC-gamma1 signalling", "R-RNO-202433:r:Generation of second messenger molecules", "R-DME-2025928:r:Calcineurin activates NFAT", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-445355:r:Smooth Muscle Contraction", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-210990:r:PECAM1 interactions", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-DME-3928664:r:Ephrin signaling", "R-RNO-8949215:r:Mitochondrial calcium ion transport", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-DRE-1483191:r:Synthesis of PC", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-114608:r:Platelet degranulation", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-9013408:r:RHOG GTPase cycle", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-112043:r:PLC beta mediated events", "R-DME-9648002:r:RAS processing", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-GGA-9013419:r:RHOT2 GTPase cycle", "R-MMU-9646399:r:Aggrephagy", "R-DRE-1483166:r:Synthesis of PA", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9648002:r:RAS processing", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-PFA-171007:r:p38MAPK events", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-HSA-948021:r:Transport to the Golgi and subsequent modification", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-BTA-201451:r:Signaling by BMP", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-1483166:r:Synthesis of PA", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8949664:r:Processing of SMDT1", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-111933:r:Calmodulin induced events", "R-SSC-5627123:r:RHO GTPases activate PAKs", "R-RNO-1482925:r:Acyl chain remodelling of PG", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-8949215:r:Mitochondrial calcium ion transport", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-MMU-912631:r:Regulation of signaling by CBL", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9706369:r:Negative regulation of FLT3", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-GGA-114608:r:Platelet degranulation", "R-DME-203615:r:eNOS activation", "R-MMU-8873719:r:RAB geranylgeranylation", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-DDI-442660:r:SLC-mediated transport of neurotransmitters", "R-CEL-445355:r:Smooth Muscle Contraction", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-6807004:r:Negative regulation of MET activity", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-XTR-1482925:r:Acyl chain remodelling of PG", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-182971:r:EGFR downregulation", "R-CEL-425561:r:Sodium/Calcium exchangers", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-CEL-70688:r:Proline catabolism", "R-HSA-9856872:r:Malate-aspartate shuttle", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-DME-9619229:r:Activation of RAC1 downstream of NMDARs", "R-DME-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9766229:r:Degradation of CDH1", "R-DME-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-1268020:r:Mitochondrial protein import", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-BTA-392517:r:Rap1 signalling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9610379:r:HCMV Late Events", "R-DME-445095:r:Interaction between L1 and Ankyrins", "R-HSA-9865881:r:Complex III assembly", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-425561:r:Sodium/Calcium exchangers", "R-CEL-114608:r:Platelet degranulation", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-8853659:r:RET signaling", "R-DRE-1482788:r:Acyl chain remodelling of PC", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-390522:r:Striated Muscle Contraction", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-RNO-163615:r:PKA activation", "R-DRE-9013425:r:RHOT1 GTPase cycle", "R-HSA-9620244:r:Long-term potentiation", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-CEL-111957:r:Cam-PDE 1 activation", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-8873719:r:RAB geranylgeranylation", "R-MMU-6799990:r:Metal sequestration by antimicrobial proteins", "R-DME-1482839:r:Acyl chain remodelling of PE", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-111933:r:Calmodulin induced events", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-186763:r:Downstream signal transduction", "R-BTA-114608:r:Platelet degranulation", "R-DRE-8949215:r:Mitochondrial calcium ion transport", "R-HSA-112043:r:PLC beta mediated events", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-SPO-114604:r:GPVI-mediated activation cascade", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-6799990:r:Metal sequestration by antimicrobial proteins", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-RNO-2672351:r:Stimuli-sensing channels", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-DME-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-PFA-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-8949215:r:Mitochondrial calcium ion transport", "R-HSA-354192:r:Integrin signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-SSC-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-BTA-163560:r:Triglyceride catabolism", "R-HSA-163560:r:Triglyceride catabolism", "R-DME-1482801:r:Acyl chain remodelling of PS", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-XTR-1482788:r:Acyl chain remodelling of PC", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-1483166:r:Synthesis of PA", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8949664:r:Processing of SMDT1", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-2160916:r:Hyaluronan degradation", "R-HSA-163615:r:PKA activation", "R-HSA-9696273:r:RND1 GTPase cycle", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-9648002:r:RAS processing", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-XTR-1482839:r:Acyl chain remodelling of PE", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DRE-9013408:r:RHOG GTPase cycle", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-BTA-8949664:r:Processing of SMDT1", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8876725:r:Protein methylation", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-SSC-6809371:r:Formation of the cornified envelope", "R-SSC-445355:r:Smooth Muscle Contraction", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-RNO-8876725:r:Protein methylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-XTR-9013419:r:RHOT2 GTPase cycle", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-CEL-389661:r:Glyoxylate metabolism and glycine degradation", "R-PFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-912631:r:Regulation of signaling by CBL", "R-GGA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DME-1482788:r:Acyl chain remodelling of PC", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-203615:r:eNOS activation", "R-HSA-209968:r:Thyroxine biosynthesis", "R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-4086398:r:Ca2+ pathway", "R-DDI-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-CEL-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9013425:r:RHOT1 GTPase cycle", "R-GGA-445355:r:Smooth Muscle Contraction", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-392517:r:Rap1 signalling", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-MMU-5673000:r:RAF activation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-203615:r:eNOS activation", "R-BTA-3000497:r:Scavenging by Class H Receptors", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-MMU-209968:r:Thyroxine biosynthesis", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9766229:r:Degradation of CDH1", "R-GGA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-354192:r:Integrin signaling", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-114604:r:GPVI-mediated activation cascade", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-MMU-111957:r:Cam-PDE 1 activation", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-DME-8963693:r:Aspartate and asparagine metabolism", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-BTA-1483166:r:Synthesis of PA", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-201451:r:Signaling by BMP", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-DME-111957:r:Cam-PDE 1 activation", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-BTA-111447:r:Activation of BAD and translocation to mitochondria", "R-BTA-6799990:r:Metal sequestration by antimicrobial proteins", "R-DME-5578775:r:Ion homeostasis", "R-PFA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-9768777:r:Regulation of NPAS4 gene transcription", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-112043:r:PLC beta mediated events", "R-BTA-399997:r:Acetylcholine regulates insulin secretion", "R-BTA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DME-209968:r:Thyroxine biosynthesis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-8949215:r:Mitochondrial calcium ion transport", "R-MMU-1433559:r:Regulation of KIT signaling", "R-GGA-9035034:r:RHOF GTPase cycle", "R-XTR-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1483166:r:Synthesis of PA", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-5621480:r:Dectin-2 family", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-BTA-9013419:r:RHOT2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-CEL-163615:r:PKA activation", "R-DME-5673000:r:RAF activation", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-373753:r:Nephrin family interactions", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-PFA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-BTA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-MMU-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-MMU-425561:r:Sodium/Calcium exchangers", "R-RNO-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-5635838:r:Activation of SMO", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-354192:r:Integrin signaling", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-8949664:r:Processing of SMDT1", "R-MMU-114608:r:Platelet degranulation", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-977225:r:Amyloid fiber formation", "R-SSC-209968:r:Thyroxine biosynthesis", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-9013424:r:RHOV GTPase cycle", "R-XTR-1483166:r:Synthesis of PA", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-GGA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SPO-114608:r:Platelet degranulation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-1169092:r:Activation of RAS in B cells", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-2160916:r:Hyaluronan degradation", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-XTR-1482801:r:Acyl chain remodelling of PS", "R-BTA-5689880:r:Ub-specific processing proteases", "R-RNO-1483191:r:Synthesis of PC", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-70221:r:Glycogen breakdown (glycogenolysis)", "R-MMU-201556:r:Signaling by ALK", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-MMU-9013419:r:RHOT2 GTPase cycle", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-112043:r:PLC beta mediated events", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-111997:r:CaM pathway", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-SCE-193648:r:NRAGE signals death through JNK", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-112043:r:PLC beta mediated events", "R-DME-112043:r:PLC beta mediated events", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-SSC-114508:r:Effects of PIP2 hydrolysis", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-201451:r:Signaling by BMP", "R-DME-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-DME-111933:r:Calmodulin induced events", "R-DME-1483166:r:Synthesis of PA", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-114608:r:Platelet degranulation", "R-PFA-8847453:r:Synthesis of PIPs in the nucleus", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-HSA-9022535:r:Loss of phosphorylation of MECP2 at T308", "R-MMU-2672351:r:Stimuli-sensing channels", "R-RNO-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-MMU-5621480:r:Dectin-2 family", "R-RNO-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-SPO-202433:r:Generation of second messenger molecules", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-425561:r:Sodium/Calcium exchangers", "R-CEL-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-9619229:r:Activation of RAC1 downstream of NMDARs", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-9856872:r:Malate-aspartate shuttle", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-DRE-1482925:r:Acyl chain remodelling of PG", "R-CFA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-BTA-445355:r:Smooth Muscle Contraction", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-MMU-6809371:r:Formation of the cornified envelope", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-BTA-9646399:r:Aggrephagy", "R-CEL-9013425:r:RHOT1 GTPase cycle", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-CEL-209968:r:Thyroxine biosynthesis", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-RNO-209968:r:Thyroxine biosynthesis", "R-HSA-445355:r:Smooth Muscle Contraction", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-CEL-1483166:r:Synthesis of PA", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-1483191:r:Synthesis of PC", "R-CFA-209968:r:Thyroxine biosynthesis", "R-RNO-4086398:r:Ca2+ pathway", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-5578775:r:Ion homeostasis", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-BTA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-2025928:r:Calcineurin activates NFAT", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-BTA-112043:r:PLC beta mediated events", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-8949215:r:Mitochondrial calcium ion transport", "R-HSA-1489509:r:DAG and IP3 signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-210990:r:PECAM1 interactions", "R-DDI-416476:r:G alpha (q) signalling events", "R-MMU-9013408:r:RHOG GTPase cycle", "R-DDI-114608:r:Platelet degranulation", "R-DME-445355:r:Smooth Muscle Contraction", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-RNO-425561:r:Sodium/Calcium exchangers", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-MMU-163560:r:Triglyceride catabolism", "R-HSA-8949664:r:Processing of SMDT1", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-PFA-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-5673000:r:RAF activation", "R-DME-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-182971:r:EGFR downregulation", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-BTA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-CEL-9648002:r:RAS processing", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DME-8876725:r:Protein methylation", "R-RNO-163560:r:Triglyceride catabolism", "R-MMU-1483166:r:Synthesis of PA", "R-PFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-111933:r:Calmodulin induced events", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-193648:r:NRAGE signals death through JNK", "R-DDI-8963693:r:Aspartate and asparagine metabolism", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-DDI-202433:r:Generation of second messenger molecules", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-XTR-8957275:r:Post-translational protein phosphorylation", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-9013419:r:RHOT2 GTPase cycle", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-9694548:r:Maturation of spike protein", "R-PFA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-445355:r:Smooth Muscle Contraction", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-MMU-163615:r:PKA activation", "R-DME-416476:r:G alpha (q) signalling events", "R-SPO-9013420:r:RHOU GTPase cycle", "R-CEL-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-CEL-163560:r:Triglyceride catabolism", "R-DME-936837:r:Ion transport by P-type ATPases", "R-BTA-3928664:r:Ephrin signaling", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by 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"R-SCE-450385", "R-HSA-4420097", "R-HSA-159230", "R-DME-1660499", "R-CEL-1433559", "R-RNO-202424", "R-CEL-9856649", "R-SCE-192105", "R-MMU-73779", "R-DME-6804759", "R-SSC-3000178", "R-SPO-75953", "R-HSA-430039", "R-RNO-201556", "R-DME-3371453", "R-HSA-9665686", "R-SPO-5607764", "R-RNO-9020933", "R-SSC-8984722", "R-MMU-192105", "R-HSA-9755511", "R-RNO-5658623", "R-HSA-9648025", "R-BTA-912631", "R-DDI-72086", "R-RNO-8964616", "R-MMU-674695", "R-MMU-111933", "R-MMU-9018519", "R-HSA-3301854", "R-MMU-8875555", "R-DME-5654710", "R-RNO-1660517", "R-RNO-389513", "R-CFA-9013106", "R-MMU-9913351", "R-MMU-8866427", "R-HSA-5654720", "R-SPO-9013424", "R-RNO-445989", "R-DRE-446353", "R-HSA-418890", "R-HSA-8948751", "R-BTA-114604", "R-MMU-199418", "R-MMU-5654688", "R-BTA-9013106", "R-MMU-375165", "R-RNO-977443", "R-HSA-2122948", "R-DME-392451", "R-SCE-5627123", "R-MMU-203615", "R-HSA-72086", "R-MMU-9845576", "R-DDI-9013149", "R-DDI-381676", "R-CEL-8876198", "R-HSA-6802946", "R-HSA-167152", "R-RNO-190873", "R-BTA-2871796", "R-DME-8856828", "R-RNO-9013106", "R-CEL-1660661", "R-MMU-5654228", "R-BTA-373752", "R-MMU-5654719", "R-SPO-1257604", "R-CEL-430039", "R-BTA-5635838", "R-SPO-77075", "R-MMU-202433", "R-RNO-6811434", "R-MMU-5357786", "R-SSC-9027276", "R-MMU-8849469", "R-CEL-9841251", "R-SSC-1855204", "R-HSA-6807878", "R-MMU-3928663", "R-MMU-9006335", "R-XTR-9035034", "R-GGA-389357", "R-CEL-180336", "R-RNO-5625900", "R-BTA-9013408", "R-RNO-5218921", "R-SPO-5696400", "R-HSA-9705462", "R-DDI-1483166", "R-DDI-114508", "R-MMU-9634638", "R-DRE-416476", "R-RNO-186763", "R-HSA-163615", "R-HSA-9696273", "R-CEL-5654704", "R-HSA-2453902", "R-RNO-9013026", "R-DDI-114604", "R-RNO-9013422", "R-HSA-5626978", "R-BTA-5357786", "R-GGA-446388", "R-HSA-2871796", "R-MMU-3928665", "R-RNO-444473", "R-RNO-9020591", "R-SPO-1660499", "R-MMU-933542", "R-RNO-9018519", "R-DDI-202424", "R-HSA-5654695", "R-CEL-9013407", "R-HSA-69656", "R-HSA-9662360", "R-SCE-8980692", "R-BTA-6811558", "R-SCE-1660517", "R-RNO-375165", "R-HSA-8875513", "R-SPO-6796648", "R-SPO-4085377", "R-HSA-6802955", "R-HSA-8984722", "R-DDI-6798695", "R-CFA-9013148", "R-HSA-6802948", "R-CEL-74751", "R-RNO-6804759", "R-CEL-674695", "R-SCE-1632852", "R-HSA-5654700", "R-CEL-1433557", "R-RNO-5654228", "R-MMU-179812", "R-RNO-3232142", "R-MMU-1250196", "R-HSA-9609736", "R-DDI-9013418", "R-RNO-5654699", "R-HSA-9634597", "R-DME-202424", "R-MMU-444473", "R-MMU-5674135", "R-BTA-5620916", "R-HSA-1059683", "R-HSA-202433", "R-SPO-159227", "R-RNO-165181", "R-HSA-6788467", "R-DME-111933", "R-DDI-5674499", "R-MMU-1483248", "R-RNO-9860927", "R-RNO-450604", "R-RNO-8874081", "R-MMU-9034793", "R-HSA-114608", "R-MMU-9020591", "R-DME-199418", "R-RNO-354192", "R-HSA-8849474", "R-HSA-9013148", "R-HSA-1963642", "R-DDI-76042", "R-RNO-5674135", "R-HSA-4615885", "R-MMU-5621480", "R-DDI-5689880", "R-MMU-5696400", "R-DDI-5628897", "R-RNO-2132295", "R-BTA-5654699", "R-HSA-399719", "R-HSA-9696270", "R-HSA-168271", "R-DDI-1474151", "R-CEL-9755511", "R-SCE-6781823", "R-RNO-399719", "R-HSA-74749", "R-BTA-418885", "R-MMU-3214858", "R-BTA-416482", "R-HSA-180336", "R-RNO-9013423", "R-DRE-983231", "R-HSA-9009391", "R-HSA-193634", "R-DME-5654712", "R-HSA-167290", "R-HSA-5357956", "R-CEL-179812", "R-HSA-3928665", "R-SPO-6782210", "R-BTA-983695", "R-MMU-8851907", "R-HSA-9027277", "R-SPO-1660517", "R-HSA-2428928", "R-DME-186763", "R-HSA-76042", "R-MMU-9696273", "R-DME-6782210", "R-HSA-9725370", "R-DME-69656", "R-CEL-159236", "R-HSA-8849469", "R-MMU-416476", "R-DDI-5218921", "R-HSA-6798695", "R-CEL-210993", "R-HSA-8875555", "R-HSA-2151201", "R-MMU-5632684", "R-MMU-9856649", "R-MMU-1306955", "R-MMU-2467813", "R-HSA-112411", "R-MMU-2173791", "R-RNO-3108214", "R-MMU-4420097", "R-SCE-389357", "R-HSA-5654693", "R-RNO-198203", "R-SPO-5696395", "R-RNO-212676", "R-MMU-430039", "R-SCE-1483248", "R-HSA-75953", "R-CEL-381426", "R-CEL-4551638", "R-DME-4615885", "R-HSA-399955", "R-GGA-9013406", "R-HSA-77075", "R-RNO-198323", "R-HSA-5654221", "R-RNO-432722", "R-RNO-165158", "R-DME-674695", "R-DDI-73779", "R-MMU-165159", "R-DDI-8948751", "R-CEL-5663213", "R-SCE-76042", "R-HSA-9648895", "R-RNO-196791", "R-SCE-9035034", "R-DDI-9856530", "R-MMU-445095", "R-MMU-264876", "R-DDI-5625740", "R-MMU-8875513", "R-HSA-159236", "R-SPO-1632852", "R-MMU-400206", "R-HSA-9013407", "R-HSA-844456", "R-DDI-6782135", "R-BTA-1660516", "R-MMU-2179392", "R-DME-9634638", "R-MMU-9856530", "R-HSA-9725554", "R-RNO-8876198", "R-DDI-2871837", "R-MMU-9013148", "R-RNO-114608", "R-RNO-192105", "R-CEL-9609523", "R-SSC-877312", "R-RNO-5610780", "R-DDI-1169091", "R-MMU-198693", "R-DDI-165181", "R-RNO-110056", "R-MMU-5658442", "R-SSC-8853659", "R-HSA-6802953", "R-SPO-9856530", "R-BTA-5654704", "R-BTA-1483248", "R-RNO-8856825", "R-DDI-3295583", "R-RNO-9034793", "R-DDI-1257604", "R-MMU-5218920", "R-CEL-445144", "R-HSA-73762", "R-CEL-416572", "R-MMU-1169408", "R-HSA-186763", "R-HSA-177504", "R-HSA-983189", "R-HSA-112412", "R-MMU-3928662", "R-RNO-9766229", "R-HSA-5654710", "R-HSA-9013406", "R-DME-179812", "R-DME-9013423", "R-RNO-2871837", "R-RNO-917729", "R-RNO-1306955", "R-HSA-9607240", "R-MMU-917729", "R-HSA-9006335", "R-HSA-264876", "R-DME-5658442", "R-RNO-202433", "R-MMU-9009391", "R-HSA-5693565", "R-SPO-6781823", "R-MMU-445355", "R-RNO-5687128", "R-MMU-9013409", "R-SPO-6804756", "R-DRE-400206", "R-HSA-6804759", "R-DME-9013148", "R-HSA-73776", "R-MMU-5654706", "R-CEL-1257604", "R-RNO-210990", "R-HSA-389359", "R-SSC-112411", "R-HSA-199418", "R-RNO-450385", "R-BTA-9020558", "R-BTA-1660517", "R-HSA-2122947", "R-BTA-9634597", "R-SPO-9634635", "R-HSA-114604", "R-DME-1433559", "R-DME-9013149", "R-MMU-196025", "R-HSA-5654689", "R-DME-69202", "R-RNO-9732724", "R-CEL-450604", "R-DME-5627123", "R-HSA-983231", "R-RNO-9013407", "R-DME-114608", "R-HSA-167161", "R-MMU-376176", "R-HSA-1433559", "R-BTA-9913351", "R-MMU-9758890", "R-HSA-5696395", "R-DME-416482", "R-HSA-167160", "R-DME-1257604", "R-DME-110523", "R-DRE-9707564", "R-MMU-5687128", "R-HSA-9031628", "R-BTA-2424491", "R-MMU-5663220", "R-CEL-1660516", "R-MMU-9837999", "R-HSA-1474151", "R-BTA-5357956", "R-HSA-445095", "R-RNO-9035034", "R-DDI-199418", "R-HSA-933542", "R-HSA-9634635", "R-HSA-9665348", "R-DRE-1660517", "R-BTA-9013148", "R-HSA-1483166", "R-DME-5625740", "R-RNO-9027284", "R-BTA-9013423", "R-BTA-5654695", "R-MMU-8874081", "R-HSA-5357905", "R-CEL-389357", "R-HSA-165054", "R-HSA-9028335", "R-CFA-416572", "R-HSA-9837999", "R-GGA-193648", "R-HSA-5654719", "R-HSA-167172", "R-HSA-9032845", "R-BTA-2132295", "R-RNO-1170546", "R-SSC-1059683", "R-HSA-5610780", "R-DDI-2730905", "R-DRE-9013409", "R-HSA-5654712", "R-DME-167044", "R-SCE-1660499", "R-BTA-1250196", "R-SSC-9006335", "R-HSA-9913351", "R-MMU-8964026", "R-DME-203615", "R-HSA-917729", "R-HSA-975957", "R-SPO-73772", "R-XTR-9013406", "R-SSC-74713", "R-MMU-5654693", "R-HSA-5663220", "R-RNO-3769402", "R-HSA-9856530", "R-DDI-9013404", "R-MMU-373752", "R-HSA-9020956", "R-HSA-2426168", "R-DME-9013420", "R-MMU-8985947", "R-HSA-1989781", "R-RNO-8854214", "R-MMU-446353", "R-HSA-9013422", "R-DRE-1855204", "R-MMU-113418", "R-CEL-3301854", "R-DME-451806", "R-HSA-9766229", "R-RNO-9013149", "R-RNO-8964026", "R-MMU-9013404", "R-HSA-3928662", "R-CEL-9035034", "R-RNO-112399", "R-RNO-9758890", "R-CEL-159230", "R-RNO-9013424", "R-RNO-5625740", "R-SCE-9013149", "R-GGA-9013409", "R-CEL-8957275", "R-HSA-9707564", "R-MMU-5628897", "R-MMU-9020558", "R-MMU-5654732", "R-DME-6804758", "R-RNO-9026527", "R-MMU-5658623", "R-CEL-5654693", "R-HSA-9610379", "R-BTA-9845576", "R-DME-8980692", "R-BTA-74751", "R-DDI-5658442", "R-HSA-6784531", "R-MMU-8853659", "R-HSA-5654732", "R-CEL-114608", "R-HSA-2219530", "R-RNO-9696273", "R-HSA-6785807", "R-DME-5654688", "R-MMU-445144", "R-GGA-6798695", "R-MMU-9705462", "R-DME-354192", "R-MMU-9634635", "R-DME-110478", "R-SPO-4570464", "R-DRE-5658442", "R-MMU-2871837", "R-RNO-1358803", "R-XTR-192105", "R-HSA-5603041", "R-MMU-6782210", "R-HSA-9860927", "R-HSA-9674555", "R-RNO-983168", "R-CEL-6796648", "R-HSA-198203", "R-RNO-4420097", "R-HSA-445989", "R-MMU-69231", "R-RNO-418555", "R-MMU-73762", "R-SCE-9013423", "R-HSA-3769402", "R-CEL-8849469", "R-HSA-418889", "R-DME-6796648", "R-DDI-198323", "R-HSA-3214858", "R-HSA-5628897", "R-CEL-9013149", "R-MMU-4615885", "R-HSA-167162", "R-DME-5620916", "R-SCE-9013406", "R-MMU-2428928", "R-RNO-6804756", "R-RNO-373752", "R-HSA-9920951", "R-MMU-1855204", "R-HSA-5658623", "R-DDI-1169408", "R-HSA-211163", "R-DME-8856825", "R-HSA-9013420", "R-DDI-171007", "R-CEL-9913351", "R-RNO-6807878", "R-DME-9707564", "R-HSA-9662361", "R-MMU-73863", "R-HSA-1660661", "R-RNO-9837999", "R-MMU-112399", "R-DDI-5621575", "R-DME-159230", "R-RNO-114604", "R-DME-9614399", "R-MMU-2871809", "R-MMU-9013026", "R-RNO-5658442"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-DME-198323:r:AKT phosphorylates targets in the cytosol", "R-SPO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-DME-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-DME-211163:r:AKT-mediated inactivation of FOXO1A", "R-RNO-416476:r:G alpha (q) signalling events", "R-CEL-182971:r:EGFR downregulation", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-165159:r:MTOR signalling", "R-DME-9607240:r:FLT3 Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-MMU-9634597:r:GPER1 signaling", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DRE-8980692:r:RHOA GTPase cycle", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-DME-165159:r:MTOR signalling", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-74713:r:IRS activation", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-DME-74749:r:Signal attenuation", "R-DDI-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-DME-6794361:r:Neurexins and neuroligins", "R-BTA-210993:r:Tie2 Signaling", "R-DRE-193648:r:NRAGE signals death through JNK", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-202433:r:Generation of second messenger molecules", "R-MMU-418555:r:G alpha (s) signalling events", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-6798695:r:Neutrophil degranulation", "R-CFA-9845576:r:Glycosphingolipid transport", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-8865999:r:MET activates PTPN11", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-8853659:r:RET signaling", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-DDI-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-GGA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SPO-72086:r:mRNA Capping", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-CEL-8854214:r:TBC/RABGAPs", "R-HSA-1266695:r:Interleukin-7 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-SSC-74749:r:Signal attenuation", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-3928664:r:Ephrin signaling", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-DDI-202040:r:G-protein activation", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-1483148:r:Synthesis of PG", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-416476:r:G alpha (q) signalling events", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DDI-76005:r:Response to elevated platelet cytosolic Ca2+", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-5635838:r:Activation of SMO", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-BTA-201556:r:Signaling by ALK", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DDI-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DME-9013409:r:RHOJ GTPase cycle", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-CEL-6811438:r:Intra-Golgi traffic", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-BTA-1306955:r:GRB7 events in ERBB2 signaling", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9020591:r:Interleukin-12 signaling", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-9614399:r:Regulation of localization of FOXO transcription factors", "R-SCE-72086:r:mRNA Capping", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-9035034:r:RHOF GTPase cycle", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-74749:r:Signal attenuation", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-165159:r:MTOR signalling", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-BTA-8854214:r:TBC/RABGAPs", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-SCE-264876:r:Insulin processing", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-5673000:r:RAF activation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1266695:r:Interleukin-7 signaling", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-BTA-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-167021:r:PLC-gamma1 signalling", "R-RNO-9607240:r:FLT3 Signaling", "R-DDI-2179392:r:EGFR Transactivation by Gastrin", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-CFA-114608:r:Platelet degranulation", "R-RNO-9634597:r:GPER1 signaling", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-211163:r:AKT-mediated inactivation of FOXO1A", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-DME-74751:r:Insulin receptor signalling cascade", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-CEL-165159:r:MTOR signalling", "R-SSC-982772:r:Growth hormone receptor signaling", "R-SPO-389359:r:CD28 dependent Vav1 pathway", "R-DME-6782135:r:Dual incision in TC-NER", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-GGA-9013420:r:RHOU GTPase cycle", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-XTR-9013408:r:RHOG GTPase cycle", "R-HSA-9609690:r:HCMV Early Events", "R-BTA-8983432:r:Interleukin-15 signaling", "R-RNO-9020958:r:Interleukin-21 signaling", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-8851805:r:MET activates RAS signaling", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-CEL-199418:r:Negative regulation of the PI3K/AKT network", "R-CEL-165158:r:Activation of AKT2", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-9020956:r:Interleukin-27 signaling", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-BTA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-68877:r:Mitotic Prometaphase", "R-CEL-111933:r:Calmodulin induced events", "R-MMU-165158:r:Activation of AKT2", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-191859:r:snRNP Assembly", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-389513:r:Co-inhibition by CTLA4", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-MMU-912631:r:Regulation of signaling by CBL", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112399:r:IRS-mediated signalling", "R-DME-112412:r:SOS-mediated signalling", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9706369:r:Negative regulation of FLT3", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-5696400:r:Dual Incision in GG-NER", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-167044:r:Signalling to RAS", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-182971:r:EGFR downregulation", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-BTA-373753:r:Nephrin family interactions", "R-DME-114604:r:GPVI-mediated activation cascade", "R-RNO-5635838:r:Activation of SMO", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-GGA-9013106:r:RHOC GTPase cycle", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-191859:r:snRNP Assembly", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-164944:r:Nef and signal transduction", "R-SSC-877300:r:Interferon gamma signaling", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-445095:r:Interaction between L1 and Ankyrins", "R-MMU-982772:r:Growth hormone receptor signaling", "R-HSA-8854521:r:Interaction between PHLDA1 and AURKA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-BTA-264876:r:Insulin processing", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-165158:r:Activation of AKT2", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-8865999:r:MET activates PTPN11", "R-RNO-264876:r:Insulin processing", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-977443:r:GABA receptor activation", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-111933:r:Calmodulin induced events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-BTA-114608:r:Platelet degranulation", "R-DDI-170670:r:Adenylate cyclase inhibitory pathway", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-SPO-114604:r:GPVI-mediated activation cascade", "R-XTR-9696264:r:RND3 GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-DRE-9013408:r:RHOG GTPase cycle", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-877300:r:Interferon gamma signaling", "R-DDI-165158:r:Activation of AKT2", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-DDI-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-DME-190873:r:Gap junction degradation", "R-MMU-6811438:r:Intra-Golgi traffic", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-HSA-912631:r:Regulation of signaling by CBL", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-72086:r:mRNA Capping", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-BTA-9674555:r:Signaling by CSF3 (G-CSF)", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-CFA-6794361:r:Neurexins and neuroligins", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-74713:r:IRS activation", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-8851805:r:MET activates RAS signaling", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-354192:r:Integrin signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-190873:r:Gap junction degradation", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-167044:r:Signalling to RAS", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-8964038:r:LDL clearance", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-196025:r:Formation of annular gap junctions", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DME-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-BTA-2428933:r:SHC-related events triggered by IGF1R", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DDI-112043:r:PLC beta mediated events", "R-HSA-9707616:r:Heme signaling", "R-RNO-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-74713:r:IRS activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-XTR-8980692:r:RHOA GTPase cycle", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-GGA-8980692:r:RHOA GTPase cycle", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DDI-4086398:r:Ca2+ pathway", "R-HSA-180746:r:Nuclear import of Rev protein", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1433559:r:Regulation of KIT signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-CEL-8980692:r:RHOA GTPase cycle", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-912631:r:Regulation of signaling by CBL", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-202424:r:Downstream TCR signaling", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-210993:r:Tie2 Signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-9748787:r:Azathioprine ADME", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-SPO-165158:r:Activation of AKT2", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5635838:r:Activation of SMO", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9020933:r:Interleukin-23 signaling", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DDI-203615:r:eNOS activation", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-445144:r:Signal transduction by L1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-354192:r:Integrin signaling", "R-CEL-186763:r:Downstream signal transduction", "R-RNO-6794361:r:Neurexins and neuroligins", "R-HSA-165160:r:PDE3B signalling", "R-DRE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-114608:r:Platelet degranulation", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-1059683:r:Interleukin-6 signaling", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-186763:r:Downstream signal transduction", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-BTA-180336:r:SHC1 events in EGFR signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-8866376:r:Reelin signalling pathway", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9845576:r:Glycosphingolipid transport", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-444257:r:RSK activation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-SSC-74751:r:Insulin receptor signalling cascade", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-1169092:r:Activation of RAS in B cells", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-CEL-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-DDI-446353:r:Cell-extracellular matrix interactions", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-114608:r:Platelet degranulation", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-8854214:r:TBC/RABGAPs", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-HSA-8853659:r:RET signaling", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-167044:r:Signalling to RAS", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-DDI-2485179:r:Activation of the phototransduction cascade", "R-RNO-5673000:r:RAF activation", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-182971:r:EGFR downregulation", "R-CFA-8980692:r:RHOA GTPase cycle", "R-HSA-2424491:r:DAP12 signaling", "R-DME-196025:r:Formation of annular gap junctions", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-SPO-192105:r:Synthesis of bile acids and bile salts", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-RNO-9696264:r:RND3 GTPase cycle", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-DDI-202433:r:Generation of second messenger molecules", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-8851805:r:MET activates RAS signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-190873:r:Gap junction degradation", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-437239:r:Recycling pathway of L1", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-SPO-9013420:r:RHOU GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-DDI-9907900:r:Proteasome assembly", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-376176:r:Signaling by ROBO receptors", "R-DME-418594:r:G alpha (i) signalling events", "R-BTA-111933:r:Calmodulin induced events", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-8875656:r:MET receptor recycling", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-354192:r:Integrin signaling", "R-BTA-196025:r:Formation of annular gap junctions", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-9013424:r:RHOV GTPase cycle", "R-RNO-8866376:r:Reelin signalling pathway", "R-MMU-9020933:r:Interleukin-23 signaling", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-SPO-9013106:r:RHOC GTPase cycle", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-196025:r:Formation of annular gap junctions", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-3000178:r:ECM proteoglycans", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-SCE-9013420:r:RHOU GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-5621480:r:Dectin-2 family", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-203615:r:eNOS activation", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9748787:r:Azathioprine ADME", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DRE-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-BTA-416476:r:G alpha (q) signalling events", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-418555:r:G alpha (s) signalling events", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-202433:r:Generation of second messenger molecules", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-SSC-114608:r:Platelet degranulation", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DRE-9845576:r:Glycosphingolipid transport", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-418885:r:DCC mediated attractive signaling", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-GGA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-9845576:r:Glycosphingolipid transport", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-354192:r:Integrin signaling", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DDI-416482:r:G alpha (12/13) signalling events", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-CEL-196025:r:Formation of annular gap junctions", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-CFA-193648:r:NRAGE signals death through JNK", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SSC-9607240:r:FLT3 Signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-203615:r:eNOS activation", "R-GGA-416482:r:G alpha (12/13) signalling events", "R-CEL-9607240:r:FLT3 Signaling", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-DDI-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9035034:r:RHOF GTPase cycle", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-5673000:r:RAF activation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-DME-193648:r:NRAGE signals death through JNK", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-977443:r:GABA receptor activation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-191859:r:snRNP Assembly", "R-SCE-114604:r:GPVI-mediated activation cascade", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-XTR-9013026:r:RHOB GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-418594:r:G alpha (i) signalling events", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-CEL-9748787:r:Azathioprine ADME", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-418594:r:G alpha (i) signalling events", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-112399:r:IRS-mediated signalling", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-9706369:r:Negative regulation of FLT3", "R-BTA-180292:r:GAB1 signalosome", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-109704:r:PI3K Cascade", "R-HSA-8964026:r:Chylomicron clearance", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-SPO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-DDI-9648002:r:RAS processing", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SCE-389359:r:CD28 dependent Vav1 pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-1483166:r:Synthesis of PA", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-5621480:r:Dectin-2 family", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-8964038:r:LDL clearance", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-DDI-170968:r:Frs2-mediated activation", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-DRE-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-8875513:r:MET interacts with TNS proteins", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-373753:r:Nephrin family interactions", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-6811438:r:Intra-Golgi traffic", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-354192:r:Integrin signaling", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-CEL-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-8853659:r:RET signaling", "R-HSA-5635838:r:Activation of SMO", "R-DME-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-DDI-9031628:r:NGF-stimulated transcription", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-211163:r:AKT-mediated inactivation of FOXO1A", "R-DDI-1489509:r:DAG and IP3 signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-165158:r:Activation of AKT2", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-69202:r:Cyclin E associated events during G1/S transition", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-977225:r:Amyloid fiber formation", "R-CEL-190873:r:Gap junction degradation", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-109704:r:PI3K Cascade", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9842663:r:Signaling by LTK", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-DME-180292:r:GAB1 signalosome", "R-RNO-1266695:r:Interleukin-7 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-9645135:r:STAT5 Activation", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-182971:r:EGFR downregulation", "R-HSA-8866376:r:Reelin signalling pathway", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-GGA-9013026:r:RHOB GTPase cycle", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-DDI-416476:r:G alpha (q) signalling events", "R-CEL-3000178:r:ECM proteoglycans", "R-RNO-1433559:r:Regulation of KIT signaling", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-877312:r:Regulation of IFNG signaling", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-112412:r:SOS-mediated signalling", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5673000:r:RAF activation", "R-BTA-8875656:r:MET receptor recycling", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-DDI-445144:r:Signal transduction by L1", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-SPO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DME-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-1483166:r:Synthesis of PA", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-111933:r:Calmodulin induced events", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-BTA-203641:r:NOSTRIN mediated eNOS trafficking", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-8985947:r:Interleukin-9 signaling", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-373752:r:Netrin-1 signaling", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-DME-418555:r:G alpha (s) signalling events", "R-DDI-165159:r:MTOR signalling", "R-HSA-8854214:r:TBC/RABGAPs", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-983189:r:Kinesins", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-MMU-112412:r:SOS-mediated signalling", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-109704:r:PI3K Cascade", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DDI-392517:r:Rap1 signalling", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-8983432:r:Interleukin-15 signaling", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-9758890:r:Transport of RCbl within the body", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-BTA-109704:r:PI3K Cascade", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-201556:r:Signaling by ALK", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-MMU-74749:r:Signal attenuation", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-8964038:r:LDL clearance", "R-XTR-9013106:r:RHOC GTPase cycle", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-983189:r:Kinesins", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CEL-912631:r:Regulation of signaling by CBL", "R-RNO-9020956:r:Interleukin-27 signaling", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-190873:r:Gap junction degradation", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1433559:r:Regulation of KIT signaling", "R-RNO-202424:r:Downstream TCR signaling", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SCE-192105:r:Synthesis of bile acids and bile salts", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-SSC-3000178:r:ECM proteoglycans", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-201556:r:Signaling by ALK", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-912631:r:Regulation of signaling by CBL", "R-DDI-72086:r:mRNA Capping", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-111933:r:Calmodulin induced events", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-SPO-9013424:r:RHOV GTPase cycle", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-446353:r:Cell-extracellular matrix interactions", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-RNO-977443:r:GABA receptor activation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-MMU-203615:r:eNOS activation", "R-HSA-72086:r:mRNA Capping", "R-MMU-9845576:r:Glycosphingolipid transport", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-RNO-190873:r:Gap junction degradation", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-BTA-373752:r:Netrin-1 signaling", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-BTA-5635838:r:Activation of SMO", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-202433:r:Generation of second messenger molecules", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SSC-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-XTR-9035034:r:RHOF GTPase cycle", "R-GGA-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DDI-1483166:r:Synthesis of PA", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DRE-416476:r:G alpha (q) signalling events", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-163615:r:PKA activation", "R-HSA-9696273:r:RND1 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013026:r:RHOB GTPase cycle", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-RNO-9020591:r:Interleukin-12 signaling", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-DDI-202424:r:Downstream TCR signaling", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-SCE-8980692:r:RHOA GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-DDI-6798695:r:Neutrophil degranulation", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-RNO-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-1632852:r:Macroautophagy", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9634597:r:GPER1 signaling", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-DME-111933:r:Calmodulin induced events", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-114608:r:Platelet degranulation", "R-MMU-9020591:r:Interleukin-12 signaling", "R-DME-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-354192:r:Integrin signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-5621480:r:Dectin-2 family", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-2132295:r:MHC class II antigen presentation", "R-BTA-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-74749:r:Signal attenuation", "R-BTA-418885:r:DCC mediated attractive signaling", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-DME-186763:r:Downstream signal transduction", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9696273:r:RND1 GTPase cycle", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-416476:r:G alpha (q) signalling events", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SCE-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-5654221:r:Phospholipase C-mediated cascade, 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Genes", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9610379:r:HCMV Late Events", "R-BTA-9845576:r:Glycosphingolipid transport", "R-DME-8980692:r:RHOA GTPase cycle", "R-BTA-74751:r:Insulin receptor signalling cascade", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-8853659:r:RET signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-114608:r:Platelet degranulation", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-445144:r:Signal transduction by L1", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-354192:r:Integrin signaling", "R-MMU-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DME-110478:r:Insulin signaling pathway", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-XTR-192105:r:Synthesis of bile acids and bile salts", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-RNO-418555:r:G alpha (s) signalling events", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-373752:r:Netrin-1 signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-HSA-211163:r:AKT-mediated inactivation of FOXO1A", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DDI-171007:r:p38MAPK events", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-112399:r:IRS-mediated signalling", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-DME-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5658442:r:Regulation of RAS by GAPs"], "type": "Homologous_superfamily"}, "IPR011994": {"description": "Cytidylate kinase domain", "go_ids": ["GO:0005524", "GO:0006139", "GO:0036431"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006139:nucleobase-containing compound metabolic process:P", "GO:0036431:dCMP kinase activity:F"], "name": "Cytidylate_kinase_dom", "pathway_ids": ["PWY-7205"], "pathways": ["PWY-7205:t:CMP phosphorylation"], "type": "Domain"}, "IPR011995": {"description": "Orotidine 5'-phosphate decarboxylase, type 2", "go_ids": ["GO:0004590", "GO:0006221"], "go_terms": ["GO:0004590:orotidine-5'-phosphate decarboxylase activity:F", "GO:0006221:pyrimidine nucleotide biosynthetic process:P"], "name": "OMPdecase_type-2", "pathway_ids": ["PWY-7791", "PWY-5686", "PWY-7790"], "pathways": ["PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II"], "type": "Family"}, "IPR011998": {"description": "Envelope glycoprotein E, central and dimerisation domain, flavivirus", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "Flavi_Glycoprot_E_cen/dimer", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR012000": {"description": "Thiamine pyrophosphate enzyme, central domain", "go_ids": ["GO:0000287", "GO:0030976"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0030976:thiamine pyrophosphate binding:F"], "name": "Thiamin_PyroP_enz_cen_dom", "pathway_ids": ["R-RNO-9033241", "R-SPO-389599", "R-SPO-9033241", "R-HSA-389599", "R-DDI-389599", "R-RNO-389599", "R-SCE-9033241", "R-SCE-389599", "R-MMU-9033241", "R-DDI-9033241", "R-HSA-9033241", "R-MMU-389599"], "pathways": ["R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-389599:r:Alpha-oxidation of phytanate", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-DDI-389599:r:Alpha-oxidation of phytanate", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-SCE-9033241:r:Peroxisomal protein import", "R-SCE-389599:r:Alpha-oxidation of phytanate", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-389599:r:Alpha-oxidation of phytanate"], "type": "Domain"}, "IPR012001": {"description": "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain", "go_ids": ["GO:0030976"], "go_terms": ["GO:0030976:thiamine pyrophosphate binding:F"], "name": "Thiamin_PyroP_enz_TPP-bd_dom", "pathway_ids": ["PWY-5837", "R-RNO-9033241", "R-SPO-389599", "R-SPO-9033241", "R-HSA-389599", "R-DDI-389599", "R-RNO-389599", "R-SCE-9033241", "R-SCE-389599", "R-MMU-9033241", "R-DDI-9033241", "R-HSA-9033241", "R-MMU-389599"], "pathways": ["PWY-5837:t:2-carboxy-1,4-naphthoquinol biosynthesis", "R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-389599:r:Alpha-oxidation of phytanate", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-DDI-389599:r:Alpha-oxidation of phytanate", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-SCE-9033241:r:Peroxisomal protein import", "R-SCE-389599:r:Alpha-oxidation of phytanate", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-389599:r:Alpha-oxidation of phytanate"], "type": "Domain"}, "IPR012002": {"description": "Desulforedoxin", "go_ids": [], "go_terms": [], "name": "Desulforedoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012003": {"description": "ATP-dependent 6-phosphofructokinase, prokaryotic-type", "go_ids": ["GO:0005524", "GO:0006002", "GO:0006096", "GO:0008443"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006002:fructose 6-phosphate metabolic process:P", "GO:0006096:glycolytic process:P", "GO:0008443:phosphofructokinase activity:F"], "name": "ATP_PFK_prok-type", "pathway_ids": ["PWY-5484", "PWY-1861", "PWY-1042", "PWY-7385"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1042:t:glycolysis IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)"], "type": "Family"}, "IPR012004": {"description": "Pyrophosphate-dependent phosphofructokinase TP0108-type", "go_ids": ["GO:0003872", "GO:0005524", "GO:0006096"], "go_terms": ["GO:0003872:6-phosphofructokinase activity:F", "GO:0005524:ATP binding:F", "GO:0006096:glycolytic process:P"], "name": "PyroP-dep_PFK_TP0108", "pathway_ids": ["PWY-5484", "PWY-1861", "PWY-1042", "PWY-7385"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1042:t:glycolysis IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)"], "type": "Family"}, "IPR012006": {"description": "tRNA nucleotidyltransferase, proteobacteria", "go_ids": ["GO:0001680", "GO:0003723", "GO:0004810", "GO:0005524"], "go_terms": ["GO:0001680:tRNA 3'-terminal CCA addition:P", "GO:0003723:RNA binding:F", "GO:0004810:CCA tRNA nucleotidyltransferase activity:F", "GO:0005524:ATP binding:F"], "name": "CCA_bact", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-5978", "PWY-6365", "PWY-6689", "PWY-6129", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7366", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-5978:t:kanosamine biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR012008": {"description": "Serine/threonine-protein phosphatase with EF-hands", "go_ids": ["GO:0004721", "GO:0005506", "GO:0005509", "GO:0030145", "GO:0050906"], "go_terms": ["GO:0004721:phosphoprotein phosphatase activity:F", "GO:0005506:iron ion binding:F", "GO:0005509:calcium ion binding:F", "GO:0030145:manganese ion binding:F", "GO:0050906:detection of stimulus involved in sensory perception:P"], "name": "Ser/Thr-Pase_EF-hand_contain", "pathway_ids": ["R-HSA-2514859", "R-RNO-2514859", "R-MMU-2514859"], "pathways": ["R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Family"}, "IPR012010": {"description": "Urease, gamma subunit", "go_ids": ["GO:0009039", "GO:0019627"], "go_terms": ["GO:0009039:urease activity:F", "GO:0019627:urea metabolic process:P"], "name": "Urease_gamma", "pathway_ids": ["PWY-5704"], "pathways": ["PWY-5704:t:urea degradation II"], "type": "Family"}, "IPR012013": {"description": "Integrin beta-4 subunit", "go_ids": ["GO:0007160", "GO:0007229", "GO:0008305", "GO:0048870", "GO:0031581"], "go_terms": ["GO:0007160:cell-matrix adhesion:P", "GO:0007229:integrin-mediated signaling pathway:P", "GO:0008305:integrin complex:C", "GO:0048870:cell motility:P", "GO:0031581:hemidesmosome assembly:P"], "name": "Integrin_bsu-4", "pathway_ids": ["R-RNO-446107", "R-HSA-2022090", "R-HSA-9725554", "R-HSA-3000170", "R-HSA-3000157", "R-HSA-446107", "R-RNO-3000170", "R-MMU-3000170", "R-MMU-446107"], "pathways": ["R-RNO-446107:r:Type I hemidesmosome assembly", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-3000157:r:Laminin interactions", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-RNO-3000170:r:Syndecan interactions", "R-MMU-3000170:r:Syndecan interactions", "R-MMU-446107:r:Type I hemidesmosome assembly"], "type": "Family"}, "IPR012014": {"description": "Retroelement-encoded protein, env-related", "go_ids": [], "go_terms": [], "name": "Retroelement_env", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012015": {"description": "Uncharacterised conserved protein HTH transcriptional regulator, archaea", "go_ids": [], "go_terms": [], "name": "UCP_HTH_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012016": {"description": "Phosphomevalonate dehydratase small subunit-like", "go_ids": [], "go_terms": [], "name": "PMDh-S-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012017": {"description": "Origin-associated protein OapB-like", "go_ids": [], "go_terms": [], "name": "OapB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012019": {"description": "FeGP cofactor biosynthesis protein HcgB, guanylyltransferase", "go_ids": [], "go_terms": [], "name": "HcgB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012020": {"description": "AB hydrolase 4 family", "go_ids": [], "go_terms": [], "name": "ABHD4", "pathway_ids": ["R-CEL-1483191", "R-SCE-1483191", "R-HSA-1483191", "R-BTA-1483191", "R-DDI-1483191", "R-MMU-1483191"], "pathways": ["R-CEL-1483191:r:Synthesis of PC", "R-SCE-1483191:r:Synthesis of PC", "R-HSA-1483191:r:Synthesis of PC", "R-BTA-1483191:r:Synthesis of PC", "R-DDI-1483191:r:Synthesis of PC", "R-MMU-1483191:r:Synthesis of PC"], "type": "Family"}, "IPR012021": {"description": "Uncharacterised conserved protein UCP005278", "go_ids": [], "go_terms": [], "name": "UCP005278", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012022": {"description": "Protein of unknown function UCP005295", "go_ids": [], "go_terms": [], "name": "UCP005295", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012025": {"description": "Methanogenesis marker 6 protein", "go_ids": [], "go_terms": [], "name": "Methan_mark_6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012027": {"description": "Formylmethanofuran dehydrogenase, subunit A", "go_ids": [], "go_terms": [], "name": "Formylmethanofuran_DH_asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012028": {"description": "Guanylylpyridinol adenylase HcgE", "go_ids": [], "go_terms": [], "name": "HcgE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012029": {"description": "MJ0405", "go_ids": [], "go_terms": [], "name": "MJ0405", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012030": {"description": "Uncharacterised conserved protein UCP006563", "go_ids": [], "go_terms": [], "name": "UCP006563", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012031": {"description": "MTH0776-like", "go_ids": [], "go_terms": [], "name": "MTH0776-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012032": {"description": "MJ0065", "go_ids": [], "go_terms": [], "name": "MJ0065", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012033": {"description": "MJ0452", "go_ids": [], "go_terms": [], "name": "MJ0452", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012036": {"description": "Bacteriophage Mu, Probable terminase, large subunit gp28", "go_ids": [], "go_terms": [], "name": "Phage_Mu_Gp28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012037": {"description": "Alpha/beta-hydrolase family", "go_ids": [], "go_terms": [], "name": "Alpha/beta-hydrolase_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012038": {"description": "Uncharacterised conserved protein UCP009471", "go_ids": [], "go_terms": [], "name": "UCP009471", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012039": {"description": "Uncharacterized protein YfaP-like", "go_ids": [], "go_terms": [], "name": "YfaP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012040": {"description": "Formylmethanofuran dehydrogenase, subunit D", "go_ids": [], "go_terms": [], "name": "Formylmethanofuran_DH_dsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012041": {"description": "CPxCG-like zinc finger protein", "go_ids": [], "go_terms": [], "name": "Znf_CPxCG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012042": {"description": "Inorganic triphosphatase NeuTTM/CthTTM-like", "go_ids": [], "go_terms": [], "name": "NeuTTM/CthTTM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012043": {"description": "Pantoate kinase", "go_ids": [], "go_terms": [], "name": "PoK", "pathway_ids": ["PWY-6654"], "pathways": ["PWY-6654:t:phosphopantothenate biosynthesis III (archaea)"], "type": "Family"}, "IPR012045": {"description": "Peptidase M6, unassigned InhA-related", "go_ids": [], "go_terms": [], "name": "Pept_M6_InhA-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012046": {"description": "LytTR transcriptional regulator with ABC transporter ATP-binding domain", "go_ids": [], "go_terms": [], "name": "LytTR_ABC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012047": {"description": "Aconitase X", "go_ids": [], "go_terms": [], "name": "AcnX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012048": {"description": "Formylmethanofuran dehydrogenase, fused subunit C/D", "go_ids": ["GO:0015948", "GO:0018493", "GO:0030151"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0018493:formylmethanofuran dehydrogenase activity:F", "GO:0030151:molybdenum ion binding:F"], "name": "Formylmethanofuran_DH_csu/dsu", "pathway_ids": ["PWY-5209", "PWY-7784", "PWY-8305"], "pathways": ["PWY-5209:t:methyl-coenzyme M oxidation to CO2 I", "PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)", "PWY-8305:t:methoxylated aromatic compound degradation II"], "type": "Family"}, "IPR012049": {"description": "Menaquinone:cytochrome c reductase, cytochrome b/c subunit", "go_ids": ["GO:0005506", "GO:0009055", "GO:0016020", "GO:0020037"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0009055:electron transfer activity:F", "GO:0016020:membrane:C", "GO:0020037:heme binding:F"], "name": "MenaQ_cyt_c_Rdtase_cyt_b/c-su", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012052": {"description": "Sporulation transcription factor Spo0A", "go_ids": ["GO:0003677", "GO:0005509", "GO:0006355", "GO:0051606", "GO:0043937"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005509:calcium ion binding:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0051606:detection of stimulus:P", "GO:0043937:regulation of sporulation:P"], "name": "Spore_0_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012056": {"description": "[NiFe]-hydrogenase-3-type complex Eha, subunit EhaM", "go_ids": [], "go_terms": [], "name": "NiFe_EhaM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012061": {"description": "Glutamate synthase, large subunit domain 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{"description": "Arogenate dehydrogenase 2", "go_ids": ["GO:0033730", "GO:0006571"], "go_terms": ["GO:0033730:arogenate dehydrogenase (NADP+) activity:F", "GO:0006571:L-tyrosine biosynthetic process:P"], "name": "Arogenate_DH_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012071": {"description": "Chemotaxis glutamate methyltransferase", "go_ids": [], "go_terms": [], "name": "Chemotax_glutamate_MeTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012072": {"description": "LytTR signal transduction protein, putative", "go_ids": [], "go_terms": [], "name": "Sigtransdc_LytTR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012073": {"description": "LytTR MHYT transcriptional regulator", "go_ids": [], "go_terms": [], "name": "LytTR_MHYT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012074": {"description": "GAF-ANTAR transcription anti-termination regulator, putative", "go_ids": [], "go_terms": [], "name": "GAF_ANTAR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012075": {"description": "Glutamate synthase, large subunit domains 1/3 fusion", "go_ids": [], "go_terms": [], "name": "Glu_synth_lsu_1/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012078": {"description": "Methane/phenol monooxygenase, hydroxylase component", "go_ids": ["GO:0016709"], "go_terms": ["GO:0016709:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen:F"], "name": "MP_mOase_hydro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012079": {"description": "Bifunctional aldehyde-alcohol dehydrogenase", "go_ids": ["GO:0004022", "GO:0006066", "GO:0008774", "GO:0015976"], "go_terms": ["GO:0004022:alcohol dehydrogenase (NAD+) activity:F", "GO:0006066:alcohol metabolic process:P", "GO:0008774:acetaldehyde dehydrogenase (acetylating) activity:F", "GO:0015976:carbon utilization:P"], "name": 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dehydrogenase", "go_ids": ["GO:0055129", "GO:0004350", "GO:0050661"], "go_terms": ["GO:0055129:L-proline biosynthetic process:P", "GO:0004350:glutamate-5-semialdehyde dehydrogenase activity:F", "GO:0050661:NADP binding:F"], "name": "Glu-5-SA_DH", "pathway_ids": ["PWY-6922", "R-SCE-8964539", "R-SPO-9837999", "R-SCE-9837999", "R-SPO-8964539"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-SPO-8964539:r:Glutamate and glutamine metabolism"], "type": "Family"}, "IPR012135": {"description": "Dihydroorotate dehydrogenase, class 1/ 2", "go_ids": ["GO:0004152", "GO:0006222"], "go_terms": ["GO:0004152:dihydroorotate dehydrogenase activity:F", "GO:0006222:UMP biosynthetic process:P"], "name": "Dihydroorotate_DH_1_2", "pathway_ids": ["PWY-5686"], "pathways": ["PWY-5686:t:UMP biosynthesis I"], "type": "Family"}, 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"go_terms": ["GO:0009851:auxin biosynthetic process:P", "GO:0050361:tryptophan 2-monooxygenase activity:F"], "name": "Trp_2-mOase", "pathway_ids": ["PWY-3161"], "pathways": ["PWY-3161:t:indole-3-acetate biosynthesis III (bacteria)"], "type": "Family"}, "IPR012144": {"description": "Nitric-oxide synthase, eukaryote", "go_ids": ["GO:0004517", "GO:0005516", "GO:0006809", "GO:0010181", "GO:0020037", "GO:0050660", "GO:0050661"], "go_terms": ["GO:0004517:nitric-oxide synthase activity:F", "GO:0005516:calmodulin binding:F", "GO:0006809:nitric oxide biosynthetic process:P", "GO:0010181:FMN binding:F", "GO:0020037:heme binding:F", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0050661:NADP binding:F"], "name": "NOS_euk", "pathway_ids": ["PWY-4983", "R-MMU-1222556", "R-SSC-9033241", "R-MMU-9856530", "R-HSA-1474151", "R-HSA-392154", "R-DME-1222556", "R-RNO-9009391", "R-MMU-203615", "R-MMU-9009391", "R-MMU-203641", "R-RNO-1222556", "R-RNO-392154", "R-RNO-5218920", "R-HSA-203615", "R-RNO-9033241", "R-HSA-5218920", "R-HSA-1222556", "R-RNO-1474151", "R-MMU-392154", "R-DME-9009391", "R-HSA-5578775", "R-RNO-203641", "R-HSA-203641", "R-RNO-203754", "R-SSC-1222556", "R-HSA-9636249", "R-MMU-5218920", "R-DME-392154", "R-DME-5578775", "R-RNO-5578775", "R-DME-9033241", "R-MMU-5578775", "R-MMU-9033241", "R-HSA-6785807", "R-SSC-392154", "R-DME-203615", "R-MMU-1474151", "R-RNO-203615", "R-DME-5218920", "R-RNO-9856530", "R-HSA-203754", "R-HSA-9009391", "R-MMU-203754", "R-DME-203754", "R-DME-1474151", "R-HSA-9856530", "R-HSA-9033241", "R-DME-9856530"], "pathways": ["PWY-4983:t:nitric oxide biosynthesis II (mammals)", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-9033241:r:Peroxisomal protein import", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203615:r:eNOS activation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-203615:r:eNOS activation", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-203754:r:NOSIP mediated eNOS trafficking", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-DME-9033241:r:Peroxisomal protein import", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-203615:r:eNOS activation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-DME-203754:r:NOSIP mediated eNOS trafficking", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Family"}, "IPR012147": {"description": "Phosphate acetyl/butyryltransferase", "go_ids": ["GO:0016746"], "go_terms": ["GO:0016746:acyltransferase activity:F"], "name": "P_Ac_Bu_trans", "pathway_ids": ["PWY-8086", "PWY-1281", "PWY-8377", "PWY-5497", "PWY-5485", "PWY-6637", "PWY-5482"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1281:t:sulfoacetaldehyde degradation I", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-5485:t:pyruvate fermentation to acetate IV", "PWY-6637:t:sulfolactate degradation II", "PWY-5482:t:pyruvate fermentation to acetate II"], "type": "Family"}, "IPR012148": {"description": "Aromatic prenyltransferase DMATS-type, fungi", "go_ids": ["GO:0009820", "GO:0016765"], "go_terms": ["GO:0009820:alkaloid metabolic process:P", "GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "ABBA_DMATS-like", "pathway_ids": ["PWY-4681", "PWY-8382", "PWY-8389", "PWY-7529", "PWY-8243", "PWY-7998", "PWY-6262", "PWY-8442", "PWY-5802", "PWY-7493", "PWY-5815", "PWY-5817", "PWY-8084", "PWY-7540", "PWY-7520", "PWY-7555", "PWY-8388", "PWY-6659", "PWY-7407", "PWY-7599", "PWY-7405", "PWY-7719", "PWY-6681", "PWY-8461", "PWY-7906", "PWY-7543", "PWY-8253", "PWY-7372", "PWY-8083", "PWY-5979", "PWY-5893", "PWY-7603", "PWY-6403", "PWY-7532", "PWY-6936", "PWY-7605", "PWY-5816", "PWY-7708", "PWY-7659", "PWY-4502", "PWY-7572", "PWY-8080"], "pathways": ["PWY-4681:t:kievitone biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-8389:t:penigequinolone biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-7998:t:menaquinol-4 biosynthesis II", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-8442:t:hyperxanthone E biosynthesis", "PWY-5802:t:alizarin biosynthesis", "PWY-7493:t:paxilline and diprenylpaxilline biosynthesis", "PWY-5815:t:rubber biosynthesis", "PWY-5817:t:dodecaprenyl diphosphate biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7540:t:aflatrem biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-8388:t:aspoquinolone biosynthesis", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-6681:t:neurosporaxanthin biosynthesis", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7906:t:rhizobitoxine biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-8083:t:domoic acid biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-5893:t:tridecaprenyl diphosphate biosynthesis", "PWY-7603:t:stephacidin A biosynthesis", "PWY-6403:t:carrageenan biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-7605:t:roquefortine C biosynthesis", "PWY-5816:t:all trans undecaprenyl diphosphate biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-4502:t:wighteone and luteone biosynthesis", "PWY-7572:t:lolitrem B biosynthesis", "PWY-8080:t:kainate biosynthesis"], "type": "Family"}, "IPR012151": {"description": "Protein-tyrosine phosphatase, non-receptor type-3, -4", "go_ids": ["GO:0004725", "GO:0006470", "GO:0008092"], "go_terms": ["GO:0004725:protein tyrosine phosphatase activity:F", "GO:0006470:protein dephosphorylation:P", "GO:0008092:cytoskeletal protein binding:F"], "name": "Tyr_Pase_non-rcpt_typ-3/4", "pathway_ids": ["R-HSA-9008059", "R-MMU-182971", "R-HSA-182971", "R-CEL-5675221", "R-MMU-166016", "R-HSA-166016", "R-HSA-9022699", "R-CEL-182971", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-182971:r:EGFR downregulation", "R-HSA-182971:r:EGFR downregulation", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-CEL-182971:r:EGFR downregulation", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR012152": {"description": "Protein-tyrosine phosphatase, non-receptor type-6, -11", "go_ids": ["GO:0004725", "GO:0006470"], "go_terms": ["GO:0004725:protein tyrosine phosphatase activity:F", "GO:0006470:protein dephosphorylation:P"], "name": "Tyr_Pase_non-rcpt_typ-6/11", "pathway_ids": ["R-HSA-9607240", "R-MMU-9674555", "R-MMU-114604", "R-MMU-5654720", "R-MMU-6811558", "R-GGA-8865999", "R-GGA-5654733", "R-MMU-210990", "R-MMU-210993", "R-RNO-1433559", "R-RNO-512988", "R-RNO-8854691", "R-GGA-5654695", "R-HSA-5654695", "R-GGA-5654706", "R-MMU-201556", "R-MMU-5654706", "R-RNO-6811558", "R-RNO-210990", "R-HSA-8853659", "R-HSA-512988", "R-HSA-2586552", "R-MMU-186763", "R-HSA-114604", "R-GGA-5654689", "R-RNO-5654732", "R-RNO-210993", "R-HSA-983695", "R-HSA-5654727", "R-HSA-1170546", "R-HSA-5654689", "R-GGA-1059683", "R-GGA-5654726", "R-HSA-9927353", "R-RNO-936964", "R-MMU-5690714", "R-HSA-8934593", "R-HSA-9008059", "R-MMU-912526", "R-HSA-1433559", "R-HSA-5654700", "R-HSA-1295596", "R-HSA-909733", "R-GGA-389948", "R-GGA-912694", "R-MMU-5654712", "R-RNO-5654712", "R-HSA-8865999", "R-HSA-9680350", "R-RNO-6798695", "R-HSA-9705671", "R-HSA-1059683", "R-RNO-1257604", "R-MMU-8934593", "R-RNO-5654727", "R-RNO-5690714", "R-RNO-912694", "R-HSA-877312", "R-MMU-512988", "R-GGA-936964", "R-GGA-1433557", "R-MMU-936964", "R-HSA-389513", "R-MMU-109704", "R-GGA-210993", "R-HSA-5654726", "R-HSA-5654712", "R-MMU-9927353", "R-HSA-109704", "R-GGA-5654700", "R-HSA-5690714", "R-MMU-1257604", "R-HSA-110056", "R-RNO-5654689", "R-MMU-389513", "R-MMU-5654726", "R-GGA-5654712", "R-HSA-9725371", "R-RNO-5654695", "R-MMU-5654727", "R-HSA-201556", "R-HSA-877300", "R-HSA-912526", "R-RNO-5654733", "R-RNO-389948", "R-MMU-5654693", "R-RNO-983695", "R-MMU-5654689", "R-HSA-9702518", "R-HSA-391160", "R-HSA-6798695", "R-RNO-877300", "R-MMU-1433559", "R-RNO-5654726", "R-HSA-180292", "R-RNO-5654710", "R-CEL-6798695", "R-HSA-112411", "R-GGA-5654727", "R-HSA-432142", "R-RNO-9927353", "R-MMU-1295596", "R-HSA-5654693", "R-MMU-8865999", "R-MMU-432142", "R-RNO-912526", "R-HSA-936964", "R-MMU-5654695", "R-GGA-5654693", "R-MMU-5654732", "R-RNO-8865999", "R-GGA-109704", "R-GGA-8854691", "R-GGA-5654720", "R-GGA-180292", "R-RNO-201556", "R-RNO-5654693", "R-MMU-1433557", "R-MMU-180292", "R-HSA-210993", "R-RNO-8853659", "R-GGA-8853659", "R-MMU-8853659", "R-HSA-5654732", "R-HSA-2219530", "R-MMU-5654700", "R-HSA-8854691", "R-GGA-8934593", "R-HSA-982772", "R-HSA-6811558", "R-RNO-1433557", "R-RNO-389513", "R-HSA-9703648", "R-HSA-5654720", "R-MMU-6798695", "R-HSA-9674555", "R-HSA-1257604", "R-HSA-5654733", "R-GGA-5654710", "R-MMU-5654710", "R-RNO-432142", "R-RNO-9674555", "R-RNO-8934593", "R-MMU-112411", "R-RNO-1295596", "R-HSA-418886", "R-RNO-1059683", "R-RNO-109704", "R-GGA-186763", "R-HSA-210990", "R-RNO-110056", "R-GGA-6811558", "R-HSA-912694", "R-GGA-389513", "R-MMU-110056", "R-HSA-9028731", "R-GGA-1257604", "R-RNO-5654706", "R-MMU-389948", "R-MMU-8854691", "R-RNO-112411", "R-HSA-9645135", "R-GGA-210990", "R-HSA-5654706", "R-MMU-983695", "R-RNO-180292", "R-HSA-1433557", "R-GGA-432142", "R-MMU-877300", "R-HSA-186763", "R-RNO-114604", "R-GGA-5654732", "R-MMU-1059683", "R-HSA-5654710", "R-RNO-5654720", "R-MMU-5654733", "R-GGA-512988", "R-RNO-5654700", "R-HSA-389948", "R-MMU-912694", "R-RNO-186763"], "pathways": ["R-HSA-9607240:r:FLT3 Signaling", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-8865999:r:MET activates PTPN11", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-210993:r:Tie2 Signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-GGA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-GGA-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-201556:r:Signaling by ALK", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-8853659:r:RET signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-GGA-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-GGA-1059683:r:Interleukin-6 signaling", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-GGA-389948:r:Co-inhibition by PD-1", "R-GGA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-RNO-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-MMU-109704:r:PI3K Cascade", "R-GGA-210993:r:Tie2 Signaling", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-HSA-109704:r:PI3K Cascade", "R-GGA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-201556:r:Signaling by ALK", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-877300:r:Interferon gamma signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-GGA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-432142:r:Platelet sensitization by LDL", "R-RNO-9927353:r:Co-inhibition by BTLA", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-GGA-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-8865999:r:MET activates PTPN11", "R-GGA-109704:r:PI3K Cascade", "R-GGA-8854691:r:Interleukin-20 family signaling", "R-GGA-5654720:r:PI-3K cascade:FGFR4", "R-GGA-180292:r:GAB1 signalosome", "R-RNO-201556:r:Signaling by ALK", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-8853659:r:RET signaling", "R-GGA-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-GGA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-GGA-5654710:r:PI-3K cascade:FGFR3", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-432142:r:Platelet sensitization by LDL", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-109704:r:PI3K Cascade", "R-GGA-186763:r:Downstream signal transduction", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9645135:r:STAT5 Activation", "R-GGA-210990:r:PECAM1 interactions", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-GGA-432142:r:Platelet sensitization by LDL", "R-MMU-877300:r:Interferon gamma signaling", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-GGA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-186763:r:Downstream signal transduction"], "type": "Family"}, "IPR012153": {"description": "Tyrosine-protein phosphatase non-receptor type 13", "go_ids": ["GO:0004725", "GO:0006470"], "go_terms": ["GO:0004725:protein tyrosine phosphatase activity:F", "GO:0006470:protein dephosphorylation:P"], "name": "PTPN13", "pathway_ids": ["R-HSA-9008059", "R-MMU-1660499", "R-HSA-9696270", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-1660499", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Family"}, "IPR012156": {"description": "Cold shock, CspA", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "Cold_shock_CspA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012157": {"description": "Uncharacterised conserved protein, CBS/CP12", "go_ids": [], "go_terms": [], "name": "UCP_CBS_CP12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012159": {"description": "Inner membrane protein YejM-like", "go_ids": [], "go_terms": [], "name": "YejM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012160": {"description": "Lipoteichoic acid synthase-like", "go_ids": [], "go_terms": [], "name": "LtaS-like", "pathway_ids": ["PWY-6580", "PWY-6350", "PWY-7817", "PWY-7981", "PWY-7819", "PWY-6804", 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["GO:0003723:RNA binding:F", "GO:0004654:polyribonucleotide nucleotidyltransferase activity:F", "GO:0006402:mRNA catabolic process:P"], "name": "PNPase", "pathway_ids": ["R-HSA-9836573"], "pathways": ["R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Family"}, "IPR012163": {"description": "Sialyltransferase", "go_ids": ["GO:0008373", "GO:0009101"], "go_terms": ["GO:0008373:sialyltransferase activity:F", "GO:0009101:glycoprotein biosynthetic process:P"], "name": "Sialyl_trans", "pathway_ids": ["R-GGA-975577", "R-HSA-9694719", "R-RNO-9037629", "R-HSA-977068", "R-HSA-9694548", "R-GGA-4085001", "R-GGA-2022854", "R-RNO-977068", "R-HSA-9037629", "R-MMU-4085001", "R-GGA-977068", "R-BTA-2022854", "R-MMU-977068", "R-HSA-4085001", "R-XTR-4085001", "R-HSA-1912420", "R-BTA-4085001", "R-BTA-9037629", "R-MMU-975577", "R-MMU-2022854", "R-HSA-419037", "R-RNO-975577", "R-HSA-9840309", "R-HSA-2022854", "R-HSA-3656243", "R-RNO-9840309", "R-RNO-4085001", "R-MMU-9840309", "R-RNO-2022854", 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["R-CEL-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-CEL-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DRE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DRE-2046105:r:Linoleic acid (LA) metabolism", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-BTA-2046105:r:Linoleic acid (LA) metabolism"], "type": "Family"}, "IPR012173": {"description": "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10", "go_ids": ["GO:0034457", "GO:0005732", "GO:0005634", "GO:0006364"], "go_terms": ["GO:0034457:Mpp10 complex:C", "GO:0005732:sno(s)RNA-containing ribonucleoprotein complex:C", "GO:0005634:nucleus:C", "GO:0006364:rRNA processing:P"], "name": "Mpp10", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR012175": {"description": "Xanthine dehydrogenase, small subunit, bacteria", "go_ids": [], "go_terms": [], "name": "Xanth_DH_ssu_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012176": {"description": "Putative nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase", "go_ids": [], "go_terms": [], "name": "NN_dMeBzImd_PRibTrfase_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012177": {"description": "Thiamine triphosphatase, eukaryotes", "go_ids": ["GO:0006772", "GO:0050333"], "go_terms": ["GO:0006772:thiamine metabolic process:P", "GO:0050333:thiamine triphosphate phosphatase activity:F"], "name": "ThTPase_euk", "pathway_ids": ["PWY-7369", "R-RNO-196819", "R-HSA-196819", "R-MMU-196819", "R-BTA-196819"], "pathways": ["PWY-7369:t:thiamine triphosphate metabolism", "R-RNO-196819:r:Vitamin B1 (thiamin) metabolism", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Family"}, "IPR012178": {"description": "Replication factor C subunit 1", "go_ids": ["GO:0003689", "GO:0005524", "GO:0005663", "GO:0006260", "GO:0006281"], "go_terms": ["GO:0003689:DNA clamp loader activity:F", "GO:0005524:ATP binding:F", "GO:0005663:DNA replication factor C complex:C", "GO:0006260:DNA replication:P", "GO:0006281:DNA repair:P"], "name": "RFC1", "pathway_ids": 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"R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR012179": {"description": "[NiFe]-hydrogenase-3-type complex Ech, subunit EchD", "go_ids": [], "go_terms": [], "name": "NiFe-hyd_3_EchD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012180": {"description": "Predicted bifunctional ATPase/phosphotransferase", "go_ids": [], "go_terms": [], "name": "Bifunc_ATPase/PTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012182": {"description": "Bifunctional molybdenum cofactor biosynthesis MobB/MoeA", "go_ids": [], "go_terms": [], "name": "MobB_MoeA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012183": {"description": "Bifunctional FAD diphosphatase/FAD synthase", "go_ids": ["GO:0003919", "GO:0006747"], "go_terms": ["GO:0003919:FMN adenylyltransferase activity:F", "GO:0006747:FAD biosynthetic process:P"], "name": "FLAD1", "pathway_ids": ["PWY-5381", "PWY-6168", "PWY-6167", "PWY-7761", "R-DRE-196843", 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activation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-HSA-3371378:r:Regulation by c-FLIP", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-XTR-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-SSC-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-5602571:r:TRAF3 deficiency - HSE", 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"R-MMU-877312", "R-MMU-9860927", "R-HSA-354192"], "pathways": ["R-MMU-77387:r:Insulin receptor recycling", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-77387:r:Insulin receptor recycling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-RNO-8849472:r:PTK6 Down-Regulation", "R-RNO-77387:r:Insulin receptor recycling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-RNO-6807004:r:Negative regulation of MET activity", "R-RNO-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-354192:r:Integrin signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-MMU-6807004:r:Negative regulation of MET activity", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-354192:r:Integrin signaling", "R-RNO-9833482:r:PKR-mediated signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-354192:r:Integrin signaling"], "type": "Family"}, "IPR012266": {"description": "Tyrosine-protein phosphatase non-receptor type 12", "go_ids": ["GO:0004725", "GO:0006470"], "go_terms": ["GO:0004725:protein tyrosine phosphatase activity:F", "GO:0006470:protein dephosphorylation:P"], "name": "PTN12", "pathway_ids": ["R-MMU-8863795", "R-HSA-186797", "R-MMU-182971", "R-HSA-9008059", "R-HSA-182971", "R-HSA-8863795", "R-HSA-9634285", "R-HSA-1250196", "R-MMU-1250196", "R-MMU-186797"], "pathways": ["R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-186797:r:Signaling by PDGF", "R-MMU-182971:r:EGFR downregulation", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-182971:r:EGFR downregulation", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-186797:r:Signaling by PDGF"], "type": "Family"}, "IPR012267": {"description": "Peptidase S1A, acrosin", "go_ids": ["GO:0001669", "GO:0004252"], "go_terms": ["GO:0001669:acrosomal vesicle:C", "GO:0004252:serine-type endopeptidase activity:F"], "name": "Pept_S1A_acrosin", "pathway_ids": ["R-MMU-1300645", "R-RNO-1300645", "R-HSA-1300645"], "pathways": ["R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding"], "type": "Family"}, "IPR012270": {"description": "CCR4-NOT complex, subunit 3/ 5", "go_ids": ["GO:0006355", "GO:0030015"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0030015:CCR4-NOT core complex:C"], "name": "CCR4-NOT_su3/5", "pathway_ids": ["R-MMU-6804115", "R-HSA-6804115", "R-MMU-429947", "R-HSA-429947", "R-HSA-9820841"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Family"}, "IPR012280": {"description": "Semialdehyde dehydrogenase, dimerisation domain", "go_ids": ["GO:0008652", "GO:0016620", "GO:0046983"], "go_terms": ["GO:0008652:amino acid biosynthetic process:P", "GO:0016620:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor:F", "GO:0046983:protein dimerization activity:F"], "name": "Semialdhyde_DH_dimer_dom", "pathway_ids": ["PWY-7977", "PWY-6562", "PWY-2942", "PWY-8088", "PWY-8296", "PWY-6559", "PWY-6160", "PWY-5097", "PWY-7153", "PWY-8179", "PWY-2941"], "pathways": ["PWY-7977:t:L-methionine biosynthesis IV", "PWY-6562:t:norspermidine biosynthesis", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8088:t:dipicolinate biosynthesis", "PWY-8296:t:cremeomycin biosynthesis", "PWY-6559:t:spermidine biosynthesis II", "PWY-6160:t:3-dehydroquinate biosynthesis II (archaea)", "PWY-5097:t:L-lysine biosynthesis VI", "PWY-7153:t:grixazone biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Domain"}, "IPR012281": {"description": "Phospholipid biosynthesis protein, PlsX-like", "go_ids": ["GO:0006633"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P"], "name": "Phospholipid_synth_PlsX-like", "pathway_ids": ["PWY-5981"], "pathways": ["PWY-5981:t:CDP-diacylglycerol biosynthesis III"], "type": "Family"}, "IPR012286": {"description": "Tetraheme cytochrome domain", "go_ids": [], "go_terms": [], "name": "Tetraheme_cytochrome", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012289": {"description": "Lytic transglycosylase, superhelical linker", "go_ids": ["GO:0004553", "GO:0042597"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0042597:periplasmic space:C"], "name": "Lytic_TGlycosylase_superhlx_L", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012290": {"description": "Fibrinogen, alpha/beta/gamma chain, coiled coil domain", "go_ids": ["GO:0005102", "GO:0005577", "GO:0030168", "GO:0051258"], "go_terms": ["GO:0005102:signaling receptor binding:F", "GO:0005577:fibrinogen complex:C", "GO:0030168:platelet activation:P", "GO:0051258:protein polymerization:P"], "name": "Fibrinogen_a/b/g_coil_dom", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-RNO-216083", "R-HSA-6802952", "R-RNO-372708", "R-HSA-9656223", "R-HSA-977225", "R-RNO-140875", "R-RNO-354194", "R-MMU-8957275", "R-RNO-114608", "R-MMU-372708", "R-HSA-114608", "R-RNO-354192", "R-HSA-9649948", "R-HSA-6802946", "R-MMU-381426", "R-RNO-8957275", "R-RNO-5674135", "R-HSA-5686938", "R-HSA-6802955", "R-HSA-381426", "R-HSA-354192", "R-RNO-5686938", "R-HSA-166058", "R-HSA-216083", "R-HSA-6802948", "R-HSA-354194", "R-MMU-354194", "R-MMU-5686938", "R-HSA-140875", "R-MMU-140875", "R-RNO-381426", "R-MMU-216083", "R-HSA-1236974", "R-HSA-5603041", "R-HSA-5602498", "R-HSA-8957275", "R-HSA-372708", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-RNO-354192:r:Integrin signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-354192:r:Integrin signaling", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR012291": {"description": "CBM2, carbohydrate-binding domain superfamily", "go_ids": ["GO:0004553", "GO:0030247"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0030247:polysaccharide binding:F"], "name": "CBM2_carb-bd_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR012292": {"description": "Globin/Protoglobin", "go_ids": ["GO:0020037", "GO:0019825"], "go_terms": ["GO:0020037:heme binding:F", "GO:0019825:oxygen binding:F"], "name": "Globin/Proto", "pathway_ids": ["R-HSA-6798695", "R-GGA-9707564", "R-RNO-1237044", "R-HSA-1247673", "R-RNO-1247673", "R-BTA-2168880", "R-HSA-2168880", "R-GGA-1247673", "R-BTA-6798695", "R-XTR-2168880", "R-MMU-203615", "R-HSA-1237044", "R-BTA-1247673", "R-GGA-1237044", "R-HSA-203615", "R-HSA-8981607", "R-XTR-1237044", "R-MMU-9707616", "R-DRE-6798695", "R-HSA-9707564", "R-RNO-9707616", "R-HSA-9615710", "R-GGA-9707616", "R-MMU-2168880", "R-MMU-1237044", "R-DRE-8981607", "R-HSA-1222538", "R-MMU-1247673", "R-RNO-2168880", "R-HSA-983231", "R-GGA-2168880", "R-DRE-203615", "R-RNO-9707564", "R-HSA-9707616", "R-BTA-9707616", "R-XTR-6798695", "R-GGA-6798695", "R-XTR-9707616", "R-RNO-203615", "R-MMU-8981607", "R-RNO-8981607", "R-BTA-8981607", "R-XTR-9707564", "R-XTR-1247673", "R-HSA-9927020", "R-SSC-8981607", "R-HSA-9613829", "R-BTA-1237044", "R-RNO-6798695", "R-MMU-9707564", "R-BTA-9707564"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-2168880:r:Scavenging of heme from plasma", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-GGA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-6798695:r:Neutrophil degranulation", "R-XTR-2168880:r:Scavenging of heme from plasma", "R-MMU-203615:r:eNOS activation", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-BTA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-GGA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-203615:r:eNOS activation", "R-HSA-8981607:r:Intracellular oxygen transport", "R-XTR-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-9707616:r:Heme signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-RNO-9707616:r:Heme signaling", "R-HSA-9615710:r:Late endosomal microautophagy", "R-GGA-9707616:r:Heme signaling", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DRE-8981607:r:Intracellular oxygen transport", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-2168880:r:Scavenging of heme from plasma", "R-DRE-203615:r:eNOS activation", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707616:r:Heme signaling", "R-BTA-9707616:r:Heme signaling", "R-XTR-6798695:r:Neutrophil degranulation", "R-GGA-6798695:r:Neutrophil degranulation", "R-XTR-9707616:r:Heme signaling", "R-RNO-203615:r:eNOS activation", "R-MMU-8981607:r:Intracellular oxygen transport", "R-RNO-8981607:r:Intracellular oxygen transport", "R-BTA-8981607:r:Intracellular oxygen transport", "R-XTR-9707564:r:Cytoprotection by HMOX1", "R-XTR-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-9927020:r:Heme assimilation", "R-SSC-8981607:r:Intracellular oxygen transport", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR012295": {"description": "TBP domain superfamily", "go_ids": [], "go_terms": [], "name": "TBP_dom_sf", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-HSA-73772", "R-CEL-73779", "R-SPO-437239", "R-SPO-674695", "R-HSA-6807505", "R-DME-76061", "R-MMU-75953", "R-SCE-8856828", "R-HSA-427413", "R-HSA-9918485", "R-DDI-73776", "R-MMU-6804756", "R-DDI-8856825", "R-SCE-6807505", "R-SPO-76042", "R-HSA-6811434", "R-HSA-73776", "R-XTR-6811434", "R-HSA-427359", "R-DDI-674695", "R-RNO-177504", "R-HSA-76061", "R-MMU-76061", "R-CEL-75953", "R-HSA-5140745", "R-DME-75953", "R-HSA-749476", "R-DME-177504", "R-CEL-73776", "R-DME-8964038", "R-DDI-8964038", "R-SCE-76061", "R-MMU-6811434", "R-DDI-6798695", "R-BTA-5099900", "R-SPO-9018519", "R-SPO-76066", "R-HSA-432720", "R-XTR-6807878", "R-HSA-437239", "R-CEL-6807878", "R-DRE-76071", "R-MMU-5140745", "R-BTA-177504", "R-DME-6804756", "R-HSA-164940", "R-HSA-167161", "R-CEL-674695", "R-HSA-6804756", "R-SPO-8866427", "R-SPO-6811434", "R-SPO-73779", "R-MMU-73772", "R-SCE-8866427", "R-SPO-73776", "R-BTA-6811434", "R-RNO-6798695", "R-SCE-73776", "R-DDI-76066", "R-SCE-6798695", "R-SPO-76061", "R-DDI-437239", "R-DME-73779", "R-DDI-6811434", "R-CEL-73772", "R-BTA-6807878", "R-DME-73776", "R-DDI-73772", "R-DDI-8866427", "R-DRE-6811434", "R-MMU-2132295", "R-MMU-8964038", "R-DDI-9018519", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-DDI-76042", "R-MMU-73776", "R-HSA-167172", "R-BTA-2132295", "R-BTA-8856828", "R-SCE-73779", "R-HSA-76071", "R-HSA-416993", "R-MMU-437239", "R-RNO-2132295", "R-RNO-437239", "R-DME-6798695", "R-DRE-73772", "R-HSA-167590", "R-HSA-5099900", "R-MMU-76071", "R-DRE-73776", "R-DME-6811434", "R-SCE-9018519", "R-HSA-8866427", "R-HSA-9754189", "R-HSA-73863", "R-DME-76066", "R-SPO-73772", "R-DRE-76066", "R-HSA-8856825", "R-HSA-3928665", "R-CEL-9018519", "R-HSA-76042", "R-HSA-674695", "R-BTA-5140745", "R-SCE-73772", "R-HSA-8964038", "R-RNO-416993", "R-HSA-73779", "R-HSA-182218", "R-CEL-6811434", "R-SPO-6807878", "R-HSA-6798695", "R-SCE-75953", "R-DRE-73779", "R-HSA-8856828", "R-DME-76042", "R-MMU-5099900", "R-SPO-6807505", "R-BTA-6798695", "R-MMU-76066", "R-DRE-75953", "R-RNO-8964038", "R-DRE-6807505", "R-DME-5099900", "R-SPO-8856825", "R-HSA-75953", "R-DRE-6807878", "R-DDI-8856828", "R-DME-3928665", "R-MMU-73779", "R-DME-6807878", "R-DRE-76061", "R-RNO-8866427", "R-HSA-9018519", "R-MMU-76042", "R-SPO-75953", "R-RNO-432722", "R-DRE-9018519", "R-DRE-6804756", "R-MMU-5250924", "R-CEL-6807505", "R-SCE-6811434", "R-DME-674695", "R-DDI-73779", "R-RNO-432720", "R-DME-9018519", "R-DME-437239", "R-DME-5140745", "R-MMU-674695", "R-MMU-6807505", "R-DRE-5250924", "R-SCE-76042", "R-MMU-9018519", "R-DDI-6807505", "R-DME-6807505", "R-MMU-8866427", "R-SCE-674695", "R-SCE-8856825", "R-MMU-6798695", "R-SCE-76066", "R-MMU-73762", "R-HSA-2132295", "R-DME-416993", "R-SPO-6798695", "R-MMU-8856825", "R-HSA-76066", "R-MMU-432722", "R-BTA-416993", "R-DME-8866427", "R-MMU-6807878", "R-HSA-167162", "R-DRE-73863", "R-SPO-8964038", "R-DDI-76061", "R-DME-8856828", "R-MMU-432720", "R-RNO-5099900", "R-SCE-8964038", "R-HSA-432722", "R-MMU-416993", "R-DME-8856825", "R-SCE-6807878", "R-RNO-8856825", "R-RNO-6811434", "R-DRE-76042", "R-RNO-6807878", "R-DDI-432720", "R-MMU-73863", "R-HSA-6807878", "R-HSA-9679191", "R-HSA-73762", "R-SPO-8856828", "R-HSA-177504", "R-BTA-8856825", "R-BTA-8964038", "R-DRE-674695", "R-DDI-6807878", "R-SCE-437239", "R-MMU-177504", "R-HSA-5250924", "R-DDI-75953", "R-DME-73772", "R-CEL-76042"], "pathways": ["R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-437239:r:Recycling pathway of L1", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-8964038:r:LDL clearance", "R-DDI-8964038:r:LDL clearance", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-XTR-6807878:r:COPI-mediated anterograde transport", "R-HSA-437239:r:Recycling pathway of L1", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-DRE-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6798695:r:Neutrophil degranulation", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 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"R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance"], "type": "Homologous_superfamily"}, "IPR012296": {"description": "Nuclease, putative, TT1808", "go_ids": [], "go_terms": [], "name": 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"R-MMU-110362", "R-RNO-2173795", "R-DRE-3108214", "R-HSA-4641257", "R-HSA-2173795", "R-MMU-5685939", "R-MMU-5696394", "R-CEL-5696394", "R-MMU-5696400", "R-DME-4641257", "R-HSA-9683610", "R-RNO-5696395", "R-HSA-110362", "R-HSA-196807", "R-DME-5696395", "R-MMU-201681", "R-HSA-5685939", "R-DRE-5696394", "R-RNO-5696394", "R-HSA-9694631", "R-DME-5696400", "R-MMU-4641257", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-5696394", "R-RNO-5696400", "R-HSA-8948751", "R-HSA-5696400", "R-MMU-3108214"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-192814:r:vRNA Synthesis", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5545619:r:XAV939 stabilizes AXIN", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-196807:r:Nicotinate metabolism", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-DME-5696400:r:Dual Incision in GG-NER", "R-MMU-4641257:r:Degradation of AXIN", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Domain"}, "IPR012318": {"description": "Crp-type HTH domain", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "HTH_CRP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012319": {"description": "Formamidopyrimidine-DNA glycosylase, catalytic domain", "go_ids": ["GO:0019104", "GO:0003906", "GO:0006284", "GO:0008270"], "go_terms": ["GO:0019104:DNA N-glycosylase activity:F", "GO:0003906:DNA-(apurinic or apyrimidinic site) endonuclease activity:F", "GO:0006284:base-excision repair:P", "GO:0008270:zinc ion binding:F"], "name": "FPG_cat", "pathway_ids": ["R-BTA-5649702", "R-HSA-110331", "R-HSA-9629232", "R-MMU-5649702", "R-MMU-110330", "R-HSA-9616334", "R-MMU-110329", "R-HSA-110329", "R-HSA-110328", "R-HSA-9636003", "R-HSA-110330", "R-HSA-5649702", "R-MMU-110328", "R-MMU-110331", "R-BTA-110329"], "pathways": ["R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-9629232:r:Defective Base Excision Repair Associated with NEIL3", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-9616334:r:Defective Base Excision Repair Associated with NEIL1", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9636003:r:NEIL3-mediated resolution of ICLs", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-MMU-110331:r:Cleavage of the damaged purine", "R-BTA-110329:r:Cleavage of the damaged pyrimidine"], "type": "Domain"}, "IPR012325": {"description": "Assassin bug toxin-like", "go_ids": ["GO:0005576", "GO:0019855"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019855:calcium channel inhibitor activity:F"], "name": "Assassin_bug_toxin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012327": {"description": "D12 class N6 adenine-specific DNA methyltransferase", "go_ids": ["GO:0009007", "GO:0009307"], "go_terms": ["GO:0009007:site-specific DNA-methyltransferase (adenine-specific) activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "MeTrfase_D12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012328": {"description": "Chalcone/stilbene synthase, C-terminal", "go_ids": [], "go_terms": [], "name": "Chalcone/stilbene_synt_C", "pathway_ids": ["PWY-7397", "PWY-6515", "PWY-7897", "PWY-5135", "PWY-6316", "PWY-6787", "R-DDI-75105", "R-DDI-199220"], "pathways": ["PWY-7397:t:naringenin biosynthesis (engineered)", "PWY-6515:t:phloridzin biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5135:t:xanthohumol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6787:t:flavonoid biosynthesis (in equisetum)", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Domain"}, "IPR012331": {"description": "Clathrin, heavy chain, linker", "go_ids": [], "go_terms": [], "name": "Clathrin_H-chain_linker", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR012332": {"description": "Autotransporter, pectate lyase C-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Autotransporter_pectin_lyase_C", "pathway_ids": ["R-HSA-9760173", "R-HSA-9927020"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-9927020:r:Heme assimilation"], "type": "Homologous_superfamily"}, "IPR012334": {"description": "Pectin lyase fold", "go_ids": [], "go_terms": [], "name": "Pectin_lyas_fold", "pathway_ids": ["R-MMU-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-DDI-418594", "R-DDI-420499", "R-DDI-977444", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-CEL-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-418594:r:G alpha (i) signalling events", "R-DDI-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-DDI-977444:r:GABA B receptor activation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation"], "type": "Homologous_superfamily"}, "IPR012336": {"description": "Thioredoxin-like fold", "go_ids": [], "go_terms": [], "name": "Thioredoxin-like_fold", "pathway_ids": ["R-MMU-8951664", "R-SCE-8951664", "R-BTA-114608", "R-HSA-114608", "R-DDI-9755511", "R-HSA-8951664", "R-SPO-8951664", "R-HSA-9755511", "R-SCE-9755511", "R-MMU-9755511", "R-GGA-114608", "R-SPO-9755511", "R-DDI-8951664", "R-MMU-114608"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-SCE-8951664:r:Neddylation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-114608:r:Platelet degranulation", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-8951664:r:Neddylation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR012337": {"description": "Ribonuclease H-like superfamily", "go_ids": [], "go_terms": [], "name": "RNaseH-like_sf", "pathway_ids": ["R-HSA-6782135", "R-MMU-5685942", "R-HSA-174411", "R-SCE-113501", "R-RNO-69091", "R-DRE-674695", "R-SPO-5696400", "R-HSA-5687128", "R-RNO-174417", "R-HSA-5358565", "R-SPO-6791226", "R-DRE-6804115", "R-MMU-69091", "R-DME-426486", "R-CEL-72165", "R-HSA-6802952", "R-SPO-5656169", "R-HSA-2559580", "R-HSA-8936459", "R-MMU-6804756", "R-DDI-6782210", "R-CEL-69166", "R-RNO-110314", "R-SPO-9930044", "R-DDI-72163", "R-MMU-5685938", "R-MMU-110314", "R-MMU-69473", "R-DRE-75955", "R-SPO-5578749", "R-DME-68962", "R-CEL-110314", "R-HSA-9764562", "R-DDI-68962", "R-SCE-6791226", "R-DME-5655862", "R-SPO-69166", "R-MMU-9930044", "R-HSA-3270619", "R-DDI-113501", "R-RNO-174430", "R-HSA-6803529", "R-HSA-162588", "R-HSA-8934593", "R-HSA-9710421", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-HSA-6804756", "R-HSA-909733", "R-CEL-112382", "R-CEL-6782135", "R-HSA-450604", "R-RNO-174414", "R-SCE-429947", "R-HSA-426486", "R-HSA-5578749", "R-RNO-9930044", "R-HSA-162592", "R-CEL-69183", "R-MMU-429947", "R-HSA-9836573", "R-HSA-6782210", "R-MMU-5685939", "R-MMU-5693579", "R-CEL-72163", "R-MMU-5696400", "R-HSA-9701192", "R-HSA-113501", "R-HSA-2564830", "R-HSA-9839394", "R-MMU-9913635", "R-MMU-5656169", "R-HSA-9709603", "R-HSA-5685939", "R-BTA-6804115", "R-HSA-180689", "R-DDI-69166", "R-RNO-5685942", "R-HSA-162594", "R-MMU-426486", "R-MMU-5656121", "R-RNO-426486", "R-HSA-9725371", "R-SPO-113501", "R-HSA-75955", "R-SPO-6782210", "R-HSA-9909620", "R-SPO-68962", "R-HSA-674695", "R-XTR-203927", "R-SPO-426496", "R-CEL-69091", "R-MMU-426496", "R-HSA-5693616", "R-DME-6791226", "R-DME-113501", "R-DDI-68952", "R-HSA-380994", "R-HSA-5693607", "R-SPO-69091", "R-MMU-174437", "R-HSA-9759811", "R-RNO-6782210", "R-DME-674695", "R-HSA-164843", "R-RNO-5578749", "R-RNO-6791226", "R-DME-203927", "R-MMU-450604", "R-CEL-9930044", "R-GGA-6804115", "R-SCE-6782135", "R-DDI-6782135", "R-HSA-9930044", "R-HSA-3108214", "R-HSA-9704646", "R-MMU-110312", "R-SPO-110312", "R-RNO-69166", "R-RNO-68952", "R-RNO-6803529", "R-RNO-174411", "R-HSA-5685938", "R-CEL-426486", "R-MMU-5655862", "R-HSA-164516", "R-HSA-69166", "R-CEL-5696397", "R-SCE-68962", "R-MMU-68952", "R-HSA-69183", "R-HSA-69091", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-HSA-9913635", "R-DME-110314", "R-HSA-180910", "R-RNO-174437", "R-HSA-9022692", "R-HSA-174414", "R-SPO-5656121", "R-DME-75955", "R-MMU-75955", "R-HSA-164525", "R-MMU-112382", "R-RNO-69183", "R-XTR-426496", "R-DRE-426496", "R-MMU-174414", "R-RNO-5696397", "R-RNO-5656169", "R-HSA-9824594", "R-MMU-5358606", "R-DME-6782135", "R-SCE-68952", "R-MMU-5358565", "R-HSA-173107", "R-XTR-5578749", "R-MMU-6791226", "R-DME-5651801", "R-MMU-5578749", "R-HSA-68952", "R-BTA-6791226", "R-HSA-429947", "R-HSA-69473", "R-HSA-174430", "R-DDI-69183", "R-MMU-72163", "R-HSA-3248023", "R-CEL-6782210", "R-HSA-9609690", "R-MMU-69183", "R-SPO-68952", "R-HSA-177539", "R-XTR-426486", "R-SPO-110314", "R-SCE-69166", "R-HSA-9820841", "R-HSA-175567", "R-HSA-8986944", "R-HSA-426496", "R-SCE-110312", "R-DME-426496", "R-MMU-174430", "R-HSA-5685942", "R-DME-429947", "R-DME-5578749", "R-HSA-203927", "R-HSA-68962", "R-DME-68952", "R-DME-9913635", "R-HSA-72165", "R-HSA-4086398", "R-HSA-5693568", "R-MMU-5693607", "R-CEL-75955", "R-HSA-8943723", "R-RNO-426496", "R-MMU-113501", "R-HSA-5651801", "R-DME-5656169", "R-DME-5696400", "R-MMU-72165", "R-MMU-69166", "R-RNO-5696400", "R-HSA-5696400", "R-HSA-5693579", "R-SPO-72163", "R-DME-69166", "R-HSA-112382", "R-HSA-6804115", "R-SCE-69091", "R-HSA-5696397", "R-MMU-174417", "R-HSA-8948700", "R-RNO-9913635", "R-DME-5656121", "R-MMU-5693616", "R-DME-9930044", "R-HSA-5655862", "R-HSA-174417", "R-HSA-9709570", "R-SPO-426486", "R-BTA-429947", "R-CEL-203927", "R-DME-69183", "R-CEL-6791226", "R-MMU-5693568", "R-HSA-5656121", "R-HSA-4551638", "R-HSA-9018519", "R-HSA-5601884", "R-HSA-9610379", "R-SCE-69183", "R-DRE-450604", "R-MMU-68962", "R-MMU-5651801", "R-DME-69091", "R-HSA-162585", "R-HSA-110312", "R-MMU-674695", "R-RNO-429947", "R-RNO-113501", "R-MMU-203927", "R-HSA-9768778", "R-HSA-6791226", "R-HSA-9704331", "R-MMU-6782210", "R-CEL-5651801", "R-HSA-5693554", "R-MMU-174411", "R-MMU-5696397", "R-MMU-6804115", "R-SPO-429947", "R-HSA-110314", "R-SPO-5651801", "R-HSA-8853884", "R-RNO-68962", "R-RNO-203927", "R-HSA-69205", "R-MMU-6782135", "R-SPO-5655862", "R-HSA-5358606", "R-HSA-2559585", "R-HSA-5628897", "R-HSA-1912408", "R-HSA-9845323", "R-DME-110312", "R-CEL-5656169", "R-HSA-175474", "R-HSA-5656169", "R-HSA-9029569", "R-HSA-9918481", "R-GGA-429947", "R-RNO-5358606", "R-SPO-5696397", "R-RNO-5358565", "R-DDI-69091", "R-RNO-6782135", "R-SPO-69183"], "pathways": ["R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69091:r:Polymerase switching", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-69091:r:Polymerase switching", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-9930044:r:Nuclear RNA decay", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", 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"R-HSA-6790901", "R-MMU-8939236", "R-HSA-9820865", "R-DME-9907900", "R-RNO-4641257", "R-BTA-72706", "R-DDI-5689603", "R-SPO-1799339", "R-SCE-1799339", "R-MMU-532668", "R-SCE-176187", "R-DRE-110312", "R-HSA-176187", "R-MMU-202424", "R-BTA-9840373", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DRE-73776", "R-HSA-5651801", "R-MMU-156827", "R-HSA-450385", "R-RNO-77075", "R-MMU-8939902", "R-GGA-9840373", "R-XTR-382556", "R-BTA-72203", "R-HSA-844615", "R-SPO-72163", "R-DME-9937383", "R-HSA-5693579", "R-HSA-8939236", "R-HSA-112382", "R-HSA-73779", "R-BTA-983168", "R-GGA-68689", "R-CEL-975957", "R-HSA-1834941", "R-MMU-76066", "R-MMU-381042", "R-DDI-5632684", "R-SCE-450385", "R-HSA-975956", "R-HSA-110331", "R-HSA-4641257", "R-RNO-202424", "R-HSA-174113", "R-BTA-9762114", "R-CEL-6791226", "R-CEL-9856649", "R-HSA-5656121", "R-MMU-73779", "R-DDI-73762", "R-GGA-5696400", "R-SPO-75953", "R-HSA-9629569", "R-RNO-975957", "R-DRE-6804756", "R-CEL-9837999", "R-DRE-72695", "R-RNO-76042", "R-MMU-5651801", "R-HSA-9755511", "R-RNO-9931269", "R-DDI-72086", "R-DRE-5685942", "R-MMU-674695", "R-MMU-9018519", "R-MMU-9931269", "R-DDI-68949", "R-SSC-72689", "R-HSA-8948751", "R-SPO-156827", "R-RNO-5693616", "R-MMU-5696397", "R-HSA-2559586", "R-DME-450408", "R-BTA-8939902", "R-SPO-5651801", "R-BTA-9766229", "R-HSA-3371511", "R-CEL-9913635", "R-RNO-68962", "R-DME-156827", "R-DDI-9755511", "R-GGA-3108214", "R-RNO-9017802", "R-CEL-72086", "R-HSA-72086", "R-XTR-975956", "R-RNO-72689", "R-HSA-5649702", "R-HSA-9017802", "R-HSA-167152", "R-BTA-174430", "R-MMU-5689603", "R-HSA-2173796", "R-XTR-72695", "R-CEL-1236978", "R-SPO-77075", "R-GGA-351451", "R-RNO-4608870", "R-GGA-5696397", "R-SPO-9629569", "R-HSA-174411", "R-DME-532668", "R-BTA-1799339", "R-HSA-5668541", "R-DME-68689", "R-DME-5632684", "R-SPO-5696400", "R-DME-432395", "R-DME-429958", "R-DRE-9954716", "R-SPO-5358606", "R-CEL-73762", "R-DDI-174178", "R-SSC-9954716", "R-DDI-9954716", "R-BTA-5689880", "R-MMU-9770562", "R-HSA-9010553", "R-DDI-204626", "R-CEL-8941858", "R-SPO-9930044", "R-CEL-532668", "R-RNO-9018519", "R-MMU-5685938", "R-MMU-69473", "R-XTR-9840373", "R-SPO-6796648", "R-HSA-5389840", "R-BTA-72731", "R-HSA-450408", "R-CEL-69052", "R-HSA-749476", "R-SCE-5689880", "R-CEL-73776", "R-HSA-532668", "R-DDI-6798695", "R-DME-432524", "R-HSA-6803529", "R-HSA-452723", "R-CEL-674695", "R-HSA-72163", "R-HSA-2408522", "R-HSA-9670095", "R-GGA-176187", "R-DRE-5693607", "R-DME-202424", "R-DME-187577", "R-HSA-5578749", "R-GGA-5358606", "R-DME-72649", "R-GGA-174430", "R-XTR-72702", "R-BTA-4608870", "R-MMU-349425", "R-BTA-2871837", "R-PFA-156827", "R-BTA-174154", "R-DDI-69601", "R-HSA-912446", "R-DDI-76042", "R-DDI-5689880", "R-MMU-5696400", "R-DME-176187", "R-DDI-9856649", "R-CEL-9755511", "R-XTR-68962", "R-SCE-6781823", "R-MMU-5656169", "R-DRE-5655862", "R-HSA-72764", "R-BTA-9929356", "R-MMU-5676590", "R-HSA-162594", "R-HSA-167290", "R-SPO-6782210", "R-DME-450513", "R-SCE-9837999", "R-SPO-68962", "R-CEL-5419276", "R-HSA-76042", "R-DME-6782210", "R-MMU-9840373", "R-MMU-9856649", "R-HSA-6798695", "R-HSA-9825895", "R-MMU-5632684", "R-HSA-5419276", "R-HSA-2151201", "R-SPO-9907900", "R-HSA-5693616", "R-BTA-5610785", "R-MMU-2467813", "R-DME-6791226", "R-SPO-5696395", "R-DDI-9954714", "R-HSA-75953", "R-MMU-174437", "R-MMU-9929356", "R-DRE-877300", "R-HSA-77075", "R-RNO-9937383", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-975956", "R-MMU-5250924", "R-BTA-174084", "R-RNO-156827", "R-DDI-73779", "R-DME-674695", "R-DDI-8948751", "R-DME-1236978", "R-SCE-76042", "R-HSA-9648895", "R-DME-6807505", "R-DRE-69473", "R-MMU-68689", "R-CEL-9930044", "R-DME-209406", "R-BTA-72649", "R-DME-2871837", "R-MMU-400206", "R-MMU-6803529", "R-DDI-6782135", "R-DDI-975956", "R-PFA-72695", "R-MMU-110312", "R-SPO-110312", "R-CEL-72695", "R-GGA-5655862", "R-DRE-5696395", "R-RNO-5610780", "R-DME-5689603", "R-MMU-5658442", "R-HSA-110330", "R-HSA-174084", "R-MMU-4608870", "R-RNO-6803529", "R-BTA-5610780", "R-HSA-9840373", "R-DME-72695", "R-MMU-72702", "R-HSA-171306", "R-HSA-72689", "R-HSA-73762", "R-BTA-9954714", "R-DDI-349425", "R-HSA-69017", "R-BTA-9020702", "R-BTA-975956", "R-RNO-9766229", "R-HSA-174437", "R-XTR-6807505", "R-DDI-174154", "R-HSA-9633012", "R-RNO-2871837", "R-DRE-5685938", "R-RNO-68949", "R-MMU-8941858", "R-BTA-450385", "R-MMU-174154", "R-RNO-73779", "R-GGA-5693616", "R-DME-5658442", "R-RNO-5687128", "R-SPO-6781823", "R-RNO-382556", "R-MMU-110381", "R-MMU-69481", "R-BTA-76066", "R-BTA-9018519", "R-SCE-429958", "R-HSA-73776", "R-BTA-77075", "R-BTA-75815", "R-RNO-5696397", "R-MMU-5668541", "R-BTA-69601", "R-CEL-75953", "R-HSA-9763198", "R-SPO-9856649", "R-HSA-5610783", "R-BTA-68867", "R-MMU-6791226", "R-DRE-6782210", "R-BTA-75953", "R-DME-72731", "R-HSA-174430", "R-HSA-8851708", "R-RNO-5689880", "R-RNO-72649", "R-HSA-167161", "R-HSA-167160", "R-HSA-5696395", "R-CEL-72649", "R-DDI-69052", "R-MMU-5687128", "R-DME-72702", "R-BTA-9629569", "R-XTR-9629569", "R-DME-5358346", "R-MMU-9837999", "R-HSA-5685942", "R-MMU-8852276", "R-MMU-68949", "R-RNO-9840373", "R-DRE-5656169", "R-DRE-3108214", "R-BTA-6781823", "R-SCE-5358565", "R-HSA-9837999", "R-BTA-174184", "R-HSA-167172", "R-HSA-5693568", "R-DRE-6781823", "R-BTA-8939236", "R-HSA-5610780", "R-DME-432626", "R-MMU-9017802", "R-MMU-5607761", "R-CEL-5689880", "R-HSA-975957", "R-SPO-73772", "R-RNO-5696400", "R-RNO-195253", "R-HSA-2426168", "R-RNO-9629569", "R-HSA-1989781", "R-MMU-113418", "R-DME-8951664", "R-BTA-76042", "R-SPO-6807505", "R-HSA-9766229", "R-RNO-176187", "R-CEL-187577", "R-RNO-110362", "R-MMU-5693616", "R-DME-9930044", "R-BTA-9929491", "R-HSA-9709570", "R-RNO-9954716", "R-HSA-9707564", "R-HSA-429958", "R-GGA-72731", "R-MMU-9954714", "R-SCE-69183", "R-DDI-5658442", "R-MMU-68962", "R-DDI-72203", "R-CEL-113418", "R-HSA-68689", "R-GGA-6782210", "R-CEL-9929491", "R-BTA-9930044", "R-DDI-9840373", "R-MMU-2871837", "R-HSA-6791226", "R-GGA-5651801", "R-MMU-6782210", "R-RNO-983168", "R-CEL-6796648", "R-HSA-5617472", "R-DDI-72702", "R-HSA-72731", "R-SPO-382556", "R-DME-1169091", "R-GGA-5685938", "R-MMU-73762", "R-SPO-5655862", "R-SCE-5358606", "R-HSA-174184", "R-MMU-350562", "R-HSA-167162", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-RNO-6804756", "R-BTA-6796648", "R-RNO-1236978", "R-DME-68949", "R-DRE-156827", "R-SPO-5696397", "R-DRE-975956", "R-CEL-9954709", "R-SPO-72695", "R-DRE-72203", "R-XTR-156827", "R-MMU-73863", "R-MMU-5685942", "R-RNO-9837999", "R-RNO-5658442", "R-RNO-5610785", "R-DRE-6791226", "R-DDI-450513", "R-CEL-76042", "R-DME-68867", "R-MMU-75953", "R-RNO-5668541", "R-SPO-5656169", "R-CEL-450385", "R-HSA-73980", "R-HSA-75815", "R-RNO-5685939", "R-HSA-9918487", "R-SCE-204626", "R-RNO-110314", "R-MMU-8948751", "R-DME-8948751", "R-HSA-72695", "R-DME-72706", "R-DRE-75955", "R-RNO-204626", "R-HSA-69052", "R-BTA-1169091", "R-XTR-9954716", "R-DME-5676590", "R-DME-204626", "R-SPO-69166", "R-GGA-68962", "R-BTA-75955", "R-SPO-176187", "R-HSA-5607761", "R-DDI-174084", "R-RNO-5656121", "R-DRE-204626", "R-MMU-9932298", "R-RNO-5696395", "R-BTA-72702", "R-SPO-204626", "R-MMU-4641258", "R-DME-112382", "R-SSC-975957", "R-CEL-112382", "R-CEL-6782135", "R-DDI-72731", "R-RNO-9954709", "R-BTA-4641257", "R-BTA-6782210", "R-CEL-8948751", "R-DME-5389840", "R-SPO-73776", "R-MMU-9766229", "R-RNO-69481", "R-HSA-174154", "R-DDI-187577", "R-XTR-69052", "R-RNO-9932298", "R-RNO-1234176", "R-BTA-1236978", "R-DRE-5358606", "R-GGA-5685942", "R-SCE-72706", "R-SPO-76061", "R-HSA-156827", "R-SCE-69052", "R-PFA-72731", "R-HSA-9836573", "R-CEL-69183", "R-DDI-9018519", "R-HSA-9762114", "R-DDI-5358565", "R-MMU-975956"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-8951664:r:Neddylation", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-GGA-351468:r:Processing of DNA double-strand break ends", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-GGA-68949:r:Orc1 removal from chromatin", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DME-4641257:r:Degradation of AXIN", "R-XTR-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-GGA-110312:r:Translesion synthesis by REV1", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-CEL-9629569:r:Protein hydroxylation", "R-HSA-9824272:r:Somitogenesis", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-GGA-69166:r:Removal of the Flap Intermediate", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-9020702:r:Interleukin-1 signaling", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-5689603:r:UCH proteinases", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72086:r:mRNA Capping", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-72086:r:mRNA Capping", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DDI-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-SPO-5689603:r:UCH proteinases", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-PFA-381042:r:PERK regulates gene expression", "R-DDI-9930044:r:Nuclear RNA decay", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-XTR-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-DME-216167:r:Nuclear CI is degraded", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-9907900:r:Proteasome assembly", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-SCE-72086:r:mRNA Capping", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-69052:r:Switching of origins to a post-replicative state", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-5689603:r:UCH proteinases", "R-SCE-72649:r:Translation initiation complex formation", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-GGA-418124:r:Telomere maintenance", "R-HSA-5250924:r:B-WICH complex 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"R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-XTR-381042:r:PERK regulates gene expression", "R-RNO-72086:r:mRNA Capping", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-72086:r:mRNA Capping", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SSC-72649:r:Translation initiation complex formation", "R-GGA-5696395:r:Formation of Incision 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"R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-HSA-176974:r:Unwinding of DNA", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-877300:r:Interferon gamma signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9907900:r:Proteasome assembly", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-9840373:r:Cellular response to mitochondrial stress", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-4641258:r:Degradation of DVL", "R-DME-381042:r:PERK regulates gene expression", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SSC-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-72649:r:Translation initiation complex formation", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-877300:r:Interferon gamma signaling", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-68962:r:Activation of the pre-replicative complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-DME-68962:r:Activation of the pre-replicative complex", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-69481:r:G2/M Checkpoints", "R-CEL-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-9930044:r:Nuclear RNA decay", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-GGA-171319:r:Telomere Extension By Telomerase", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-XTR-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-69166:r:Removal of the Flap Intermediate", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9907900:r:Proteasome assembly", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-69052:r:Switching of origins to a post-replicative state", "R-DME-9629569:r:Protein hydroxylation", "R-DRE-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-110312:r:Translesion synthesis by REV1", "R-RNO-381042:r:PERK regulates gene expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-GGA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-9629569:r:Protein hydroxylation", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-9770562:r:mRNA Polyadenylation", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-CEL-6803529:r:FGFR2 alternative splicing", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-9629569:r:Protein hydroxylation", "R-XTR-68949:r:Orc1 removal from chromatin", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-DME-9020702:r:Interleukin-1 signaling", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-877300:r:Interferon gamma signaling", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-9709275:r:Impaired BRCA2 translocation to the nucleus", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-4641257:r:Degradation of AXIN", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-68867:r:Assembly of the pre-replicative complex", "R-HSA-9930044:r:Nuclear RNA decay", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-176187:r:Activation of ATR in response to replication stress", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-RNO-5689603:r:UCH proteinases", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-CEL-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-DRE-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-GGA-381042:r:PERK regulates gene expression", "R-HSA-381042:r:PERK regulates gene expression", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-844615:r:The AIM2 inflammasome", "R-DME-2467813:r:Separation of Sister Chromatids", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-6803529:r:FGFR2 alternative splicing", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-DRE-5656121:r:Translesion synthesis by POLI", "R-SCE-6798695:r:Neutrophil degranulation", "R-CEL-9907900:r:Proteasome assembly", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-DME-9907900:r:Proteasome assembly", "R-RNO-4641257:r:Degradation of AXIN", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-5689603:r:UCH proteinases", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-DRE-110312:r:Translesion synthesis by REV1", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-9840373:r:Cellular response to mitochondrial stress", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-GGA-9840373:r:Cellular response to mitochondrial stress", "R-XTR-382556:r:ABC-family proteins mediated transport", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-844615:r:The AIM2 inflammasome", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-381042:r:PERK regulates gene expression", "R-DDI-5632684:r:Hedgehog 'on' state", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-9629569:r:Protein hydroxylation", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-72086:r:mRNA Capping", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-9766229:r:Degradation of CDH1", "R-HSA-3371511:r:HSF1 activation", "R-CEL-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-MMU-5689603:r:UCH proteinases", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-351451:r:Homologous recombination repair of replication-dependent double-strand breaks", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SPO-9629569:r:Protein hydroxylation", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-DME-5632684:r:Hedgehog 'on' state", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-432395:r:Degradation of TIM", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-CEL-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DDI-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-9930044:r:Nuclear RNA decay", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-XTR-9840373:r:Cellular response to mitochondrial stress", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-69052:r:Switching of origins to a post-replicative state", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-5689880:r:Ub-specific processing proteases", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-432524:r:Degradation of PER", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-GGA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-72649:r:Translation initiation complex formation", "R-GGA-174430:r:Telomere C-strand synthesis initiation", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-PFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-912446:r:Meiotic recombination", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-DRE-5655862:r:Translesion synthesis by POLK", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-5419276:r:Mitochondrial translation termination", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-9907900:r:Proteasome assembly", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DRE-877300:r:Interferon gamma signaling", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-9930044:r:Nuclear RNA decay", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-PFA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-5689603:r:UCH proteinases", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-68949:r:Orc1 removal from chromatin", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-9763198:r:Impaired BRCA2 binding to SEM1 (DSS1)", "R-SPO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-72731:r:Recycling of eIF2:GDP", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-72649:r:Translation initiation complex formation", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-72649:r:Translation initiation complex formation", "R-DDI-69052:r:Switching of origins to a post-replicative state", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-9629569:r:Protein hydroxylation", "R-XTR-9629569:r:Protein hydroxylation", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-DRE-5656169:r:Termination of translesion DNA synthesis", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-9629569:r:Protein hydroxylation", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-8951664:r:Neddylation", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DME-9930044:r:Nuclear RNA decay", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-GGA-72731:r:Recycling of eIF2:GDP", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9930044:r:Nuclear RNA decay", "R-DDI-9840373:r:Cellular response to mitochondrial stress", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-GGA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-XTR-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-GGA-68962:r:Activation of the pre-replicative complex", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-DRE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-4641258:r:Degradation of DVL", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-4641257:r:Degradation of AXIN", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-DME-5389840:r:Mitochondrial translation elongation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-XTR-69052:r:Switching of origins to a post-replicative state", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-69052:r:Switching of origins to a post-replicative state", "R-PFA-72731:r:Recycling of eIF2:GDP", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "type": "Homologous_superfamily"}, "IPR012341": {"description": "Six-hairpin glycosidase-like superfamily", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "6hp_glycosidase-like_sf", "pathway_ids": ["R-MMU-70221", "R-HSA-532668", "R-HSA-189085", "R-HSA-9683686", "R-HSA-70221", "R-RNO-9840310", "R-HSA-6811438", "R-MMU-9840310", "R-HSA-901032", "R-MMU-964827", "R-HSA-381038", "R-DME-70221", "R-HSA-9694548", "R-HSA-4793954", "R-MMU-9768727", "R-HSA-9840310", "R-SCE-6798695", "R-DME-9840310", "R-HSA-964827", "R-HSA-446210", "R-CEL-70221", "R-HSA-4793950", "R-RNO-446210", "R-HSA-9768727", "R-SCE-70221", "R-CEL-964827", "R-RNO-70221", "R-SSC-446210", "R-MMU-446210", "R-RNO-9768727", "R-DME-964827"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-964827:r:Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-4793954:r:Defective MOGS causes CDG-2b", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-9840310:r:Glycosphingolipid catabolism", "R-HSA-964827:r:Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-CEL-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-4793950:r:Defective MAN1B1 causes MRT15", "R-RNO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-CEL-964827:r:Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-SSC-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-DME-964827:r:Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "type": "Homologous_superfamily"}, "IPR012344": {"description": "Matrix protein, lentiviral and alpha-retroviral, N-terminal", "go_ids": [], "go_terms": [], "name": "Matrix_HIV/RSV_N", "pathway_ids": ["R-HSA-180910", "R-HSA-164516", "R-HSA-162585", "R-HSA-1169408", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-164525", "R-HSA-162594", "R-HSA-162592", "R-HSA-177539", "R-HSA-174490", "R-HSA-175567", "R-HSA-175474", "R-HSA-174495", "R-HSA-173107"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-162588:r:Budding and 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Domain Regulates Transcription", "R-HSA-9645135:r:STAT5 Activation", "R-RNO-1266695:r:Interleukin-7 signaling", "R-CEL-1059683:r:Interleukin-6 signaling", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-SSC-9008059:r:Interleukin-37 signaling", "R-SSC-9020956:r:Interleukin-27 signaling", "R-DME-909733:r:Interferon alpha/beta signaling", "R-BTA-9020958:r:Interleukin-21 signaling", "R-DME-9008059:r:Interleukin-37 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-877312:r:Regulation of IFNG signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DME-8854691:r:Interleukin-20 family signaling", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", 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{"description": "Restriction endonuclease, type II, Cfr10I/Bse634I", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_Cfr10I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012416": {"description": "CALMODULIN-BINDING PROTEIN60", "go_ids": ["GO:0005516"], "go_terms": ["GO:0005516:calmodulin binding:F"], "name": "CBP60", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012417": {"description": "Calmodulin-binding domain, plant", "go_ids": ["GO:0005516"], "go_terms": ["GO:0005516:calmodulin binding:F"], "name": "CaM-bd_dom_pln", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012418": {"description": "CAP160", "go_ids": [], "go_terms": [], "name": "CAP160", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR012419": {"description": "Cas1p, 10 TM acyl transferase domain", "go_ids": [], "go_terms": [], "name": "Cas1_AcylTrans_dom", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR012420": {"description": "Cbp4", "go_ids": [], "go_terms": [], "name": "Cbp4", "pathway_ids": ["R-SCE-9865878"], "pathways": ["R-SCE-9865878:r:Complex III assembly"], "type": "Family"}, "IPR012421": {"description": "WisP, C-terminal", "go_ids": [], "go_terms": [], "name": "WisP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012422": {"description": "Cytochrome c oxidase, subunit IV, bacterial aa3 type", "go_ids": [], "go_terms": [], "name": "Cyt_c_oxidase_su4_bac-aa3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012423": {"description": "Chromatin modification-related protein Eaf7/MRGBP", "go_ids": ["GO:0005634", "GO:0043189", "GO:0006355"], "go_terms": ["GO:0005634:nucleus:C", "GO:0043189:H4/H2A histone acetyltransferase complex:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Eaf7/MRGBP", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR012424": {"description": "Conjugative transposon, TraJ, C-terminal", "go_ids": [], "go_terms": [], "name": "Conjugative_transposon_TraJ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012425": {"description": "DmpG-like communication", "go_ids": ["GO:0016833", "GO:0009056"], "go_terms": ["GO:0016833:oxo-acid-lyase activity:F", "GO:0009056:catabolic process:P"], "name": "DmpG_comm", "pathway_ids": ["PWY-5162"], "pathways": ["PWY-5162:t:2-hydroxypenta-2,4-dienoate degradation"], "type": "Domain"}, "IPR012426": {"description": "Cell division protein SepF, archaea", "go_ids": [], "go_terms": [], "name": "SepF_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012427": {"description": "Protein of unknown function DUF1622", "go_ids": [], "go_terms": [], "name": "DUF1622", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012428": {"description": "Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf117", "go_ids": [], "go_terms": [], "name": "AcMNPV_Orf117", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012429": {"description": "Heparan-alpha-glucosaminide N-acetyltransferase, catalytic domain", "go_ids": [], "go_terms": [], "name": "HGSNAT_cat", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-HSA-2206291", "R-MMU-2024096", "R-HSA-2024096"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2206291:r:MPS IIIC - Sanfilippo syndrome C", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-2024096:r:HS-GAG degradation"], "type": "Domain"}, "IPR012430": {"description": "Transmembrane protein 43 family", "go_ids": [], "go_terms": [], "name": "TMEM43_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012431": {"description": "PD-(D/E)XK nuclease", "go_ids": [], "go_terms": [], "name": "PDDEXK_10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012432": {"description": "Protein of unknown function DUF1627", "go_ids": [], "go_terms": [], "name": "DUF1627", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012433": {"description": "Immunity MXAN_0049 protein", "go_ids": [], "go_terms": [], "name": "Imm11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012434": {"description": "Domain of unknown function DUF1631", "go_ids": [], "go_terms": [], "name": "DUF1631", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012435": {"description": "TMEM144", "go_ids": [], "go_terms": [], "name": "TMEM144", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012436": {"description": "Protein of unknown function DUF1633", "go_ids": [], "go_terms": [], "name": "DUF1633", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012437": {"description": "Domain of unknown function DUF1638", "go_ids": [], "go_terms": [], "name": "DUF1638", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012438": {"description": "Protein of unknown function DUF1639", "go_ids": [], "go_terms": [], "name": "DUF1639", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012440": {"description": "Helical membrane plugin domain", "go_ids": [], "go_terms": [], "name": "HMP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012441": {"description": "Protein of unknown function DUF1643", "go_ids": [], "go_terms": [], "name": "DUF1643", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012442": {"description": "Protein of unknown function DUF1645, plant", "go_ids": [], "go_terms": [], "name": "DUF1645_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012443": {"description": "Protein of unknown function DUF1646", "go_ids": [], "go_terms": [], "name": "DUF1646", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012444": {"description": "Protein of unknown function DUF1647", "go_ids": [], "go_terms": [], "name": "DUF1647", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012445": {"description": "Autophagy-related protein 101", "go_ids": ["GO:0006914"], "go_terms": ["GO:0006914:autophagy:P"], "name": "ATG101", "pathway_ids": ["R-HSA-1632852", "R-RNO-1632852", "R-MMU-1632852", "R-SPO-1632852", "R-BTA-1632852", "R-DRE-1632852"], "pathways": ["R-HSA-1632852:r:Macroautophagy", "R-RNO-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-BTA-1632852:r:Macroautophagy", "R-DRE-1632852:r:Macroautophagy"], "type": "Family"}, "IPR012446": {"description": "Calcium release-activated calcium channel protein", "go_ids": [], "go_terms": [], "name": "CRAC_channel", "pathway_ids": ["R-HSA-983695", "R-HSA-5578775", "R-HSA-139853"], "pathways": ["R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels"], "type": "Family"}, "IPR012447": {"description": "Protein of unknown function DUF1651", "go_ids": [], "go_terms": [], "name": "DUF1651", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012448": {"description": "Protein of unknown function DUF1652", "go_ids": [], "go_terms": [], "name": "DUF1652", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012449": {"description": "Bacteriophage F116, Orf28", "go_ids": [], "go_terms": [], "name": "Phage_F116_Orf28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012450": {"description": "Bacteriophage bIL310, Orf15", "go_ids": [], "go_terms": [], "name": "Phage_bIL310_Orf15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012451": {"description": "Protein of unknown function DUF1656", "go_ids": [], "go_terms": [], "name": "DUF1656", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012452": {"description": "Protein of unknown function DUF1657", "go_ids": [], "go_terms": [], "name": "DUF1657", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012454": {"description": "Domain of unknown function DUF1659", "go_ids": [], "go_terms": [], "name": "DUF1659", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012455": {"description": "Protein of unknown function DUF1660", "go_ids": [], "go_terms": [], "name": "DUF1660", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012456": {"description": "Protein of unknown function DUF1661", "go_ids": [], "go_terms": [], "name": "DUF1661", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012457": {"description": "Protein of unknown function DUF1663", "go_ids": [], "go_terms": [], "name": "DUF1663", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012458": {"description": "Domain of unknown function DUF1664", "go_ids": [], "go_terms": [], "name": "DUF1664", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012459": {"description": "Ribosomal RNA-processing protein 15", "go_ids": ["GO:0006364"], "go_terms": ["GO:0006364:rRNA processing:P"], "name": "Rrp15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012460": {"description": "Protein of unknown function DUF1667", "go_ids": [], "go_terms": [], "name": "DUF1667", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012461": {"description": "Scaffolding anchor of CK1 domain", "go_ids": [], "go_terms": [], "name": "SACK1", "pathway_ids": ["R-DRE-177929", "R-HSA-9696270", "R-HSA-9696264", "R-HSA-177929", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9696273", "R-MMU-177929"], "pathways": ["R-DRE-177929:r:Signaling by EGFR", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-177929:r:Signaling by EGFR"], "type": "Domain"}, "IPR012462": {"description": "UFSP1/2/DUB, catalytic domain", "go_ids": [], "go_terms": [], "name": "UFSP1/2_DUB_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012463": {"description": "Ethylene-responsive binding factor-associated repression", "go_ids": [], "go_terms": [], "name": "Ninja_motif", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012464": {"description": "Protein of unknown function DUF1676", "go_ids": [], "go_terms": [], "name": "DUF1676", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012465": {"description": "Protein of unknown function DUF1678", "go_ids": [], "go_terms": [], "name": "DUF1678", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012466": {"description": "NECAP, PHear domain", "go_ids": ["GO:0006897", "GO:0016020"], "go_terms": ["GO:0006897:endocytosis:P", "GO:0016020:membrane:C"], "name": "NECAP_PHear", "pathway_ids": ["R-BTA-8856828", "R-DME-8856825", "R-BTA-8856825", "R-MMU-8856828", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-432722", "R-BTA-432722", "R-DME-8856828", "R-RNO-8856828", "R-DME-432722", "R-HSA-432722", "R-RNO-432722"], "pathways": ["R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR012467": {"description": "Protein of unknown function DUF1684", "go_ids": [], "go_terms": [], "name": "DUF1684", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012468": {"description": "Protein of unknown function DUF1686", "go_ids": [], "go_terms": [], "name": "DUF1686", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012469": {"description": "Protein of unknown function DUF1688", "go_ids": [], "go_terms": [], "name": "DUF1688", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012470": {"description": "PDR1 up-regulated protein 1-like", "go_ids": [], "go_terms": [], "name": "Pup1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012471": {"description": "Protein of unknown function DUF1690", "go_ids": [], "go_terms": [], "name": "DUF1690", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012472": {"description": "Mitochondrial adapter protein MCP1, transmembrane domain", "go_ids": [], "go_terms": [], "name": "MCP1_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012473": {"description": "Fibritin C-terminal", "go_ids": [], "go_terms": [], "name": "Fibritin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012474": {"description": "Frigida-like", "go_ids": [], "go_terms": [], "name": "Frigida", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012475": {"description": "Fucose-specific lectin", "go_ids": [], "go_terms": [], "name": "Fungal_lectin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012476": {"description": "mRNA export factor GLE1-like", "go_ids": ["GO:0005643", "GO:0016973"], "go_terms": ["GO:0005643:nuclear pore:C", "GO:0016973:poly(A)+ mRNA export from nucleus:P"], "name": "GLE1", "pathway_ids": ["R-RNO-159236", "R-BTA-159236", "R-HSA-159236", "R-DRE-159236", "R-DME-159236", "R-SPO-159236", "R-MMU-159236"], "pathways": ["R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR012477": {"description": "Glycosyltransferase family 52", "go_ids": [], "go_terms": [], "name": "Glyco_transf_52", "pathway_ids": ["PWY-7434", "PWY-7426", "PWY-7841", "PWY-7831", "PWY-7833"], "pathways": ["PWY-7434:t:terminal O-glycans residues modification (via type 2 precursor disaccharide)", "PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "PWY-7841:t:neolacto-series glycosphingolipids biosynthesis", "PWY-7831:t:ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide", "PWY-7833:t:biosynthesis of Lewis epitopes (H. pylori)"], "type": "Family"}, "IPR012478": {"description": "GSG1-like", "go_ids": [], "go_terms": [], "name": "GSG-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012479": {"description": "SAP30-binding protein", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "SAP30BP", "pathway_ids": ["R-HSA-427413"], "pathways": ["R-HSA-427413:r:NoRC negatively regulates rRNA expression"], "type": "Family"}, "IPR012480": {"description": "Heparinase II/III-like, C-terminal", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "Hepar_II_III_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012481": {"description": "Kanamycin nucleotidyltransferase, C-terminal", "go_ids": ["GO:0016779", "GO:0046677"], "go_terms": ["GO:0016779:nucleotidyltransferase activity:F", "GO:0046677:response to antibiotic:P"], "name": "KNTase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012483": {"description": "Inner membrane mitoribosome receptor Mba1, Saccharomycetales", "go_ids": ["GO:0005743", "GO:0043022"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C", "GO:0043022:ribosome binding:F"], "name": "Mba1_Saccharomycetales", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012484": {"description": "Metallothionein family 7", "go_ids": ["GO:0046870"], "go_terms": ["GO:0046870:cadmium ion binding:F"], "name": "Metalthion_7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012485": {"description": "Centromere protein I", "go_ids": ["GO:0034080", "GO:0000070", "GO:0000776"], "go_terms": ["GO:0034080:CENP-A containing chromatin assembly:P", "GO:0000070:mitotic sister chromatid segregation:P", "GO:0000776:kinetochore:C"], "name": "CENP-I", "pathway_ids": ["R-MMU-2500257", "R-HSA-606279", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-2500257", "R-RNO-606279", "R-MMU-2467813", "R-MMU-606279", "R-HSA-141444", "R-MMU-68877", "R-HSA-9648025", "R-RNO-5663220", "R-HSA-68877", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR012486": {"description": "Far11/STRP, N-terminal", "go_ids": [], "go_terms": [], "name": "Far11/STRP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012487": {"description": "Nairovirus M polyprotein-like", "go_ids": [], "go_terms": [], "name": "Nairovirus_M", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012488": {"description": "Nodule-specific GRP-repeat", "go_ids": [], "go_terms": [], "name": "Nod_GRP", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR012489": {"description": "Nuclease A inhibitor-like", "go_ids": [], "go_terms": [], "name": "NucleaseA_inhib-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012490": {"description": "PaRep2a", "go_ids": [], "go_terms": [], "name": "PaRep2a", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012491": {"description": "Protein Red1/Rec10", "go_ids": ["GO:0007131"], "go_terms": ["GO:0007131:reciprocal meiotic recombination:P"], "name": "Red1/Rec10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012492": {"description": "Protein RED, C-terminal", "go_ids": [], "go_terms": [], "name": "RED_C", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-CEL-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR012493": {"description": "Renin receptor-like", "go_ids": ["GO:0038023", "GO:0016020"], "go_terms": ["GO:0038023:signaling receptor activity:F", "GO:0016020:membrane:C"], "name": "Renin_rcpt", "pathway_ids": ["R-HSA-6798695", "R-BTA-2022377", "R-DME-6798695", "R-MMU-6798695", "R-DME-2022377", "R-BTA-6798695", "R-RNO-2022377", "R-HSA-2022377", "R-RNO-6798695", "R-MMU-2022377"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Family"}, "IPR012494": {"description": "Reovirus minor core protein, Mu-2", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Reovirus_Mu2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012495": {"description": "TadE-like domain", "go_ids": [], "go_terms": [], "name": "TadE-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012496": {"description": "TMC domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TMC_dom", "pathway_ids": ["R-HSA-9662360", "R-MMU-6798695", "R-HSA-9662361", "R-HSA-6798695"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR012497": {"description": "Neurotoxin B-IV-like", "go_ids": ["GO:0005576", "GO:0019871"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019871:sodium channel inhibitor activity:F"], "name": "Neurotoxin_B-IV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012498": {"description": "Alpha-A conotoxin PIVA-like", "go_ids": ["GO:0005576", "GO:0030550"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0030550:acetylcholine receptor inhibitor activity:F"], "name": "Toxin_14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012499": {"description": "Janus-atracotoxin", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Toxin_16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012500": {"description": "Clostridium neurotoxin, translocation", "go_ids": ["GO:0008320"], "go_terms": ["GO:0008320:transmembrane protein transporter activity:F"], "name": "Toxin_trans", "pathway_ids": ["R-HSA-5250989", "R-HSA-5250968", "R-HSA-5250971", "R-HSA-5250982", "R-HSA-5250992", "R-HSA-5250955", "R-HSA-5250981", "R-HSA-5250958"], "pathways": ["R-HSA-5250989:r:Toxicity of botulinum toxin type G (botG)", "R-HSA-5250968:r:Toxicity of botulinum toxin type A (botA)", "R-HSA-5250971:r:Toxicity of botulinum toxin type C (botC)", "R-HSA-5250982:r:Toxicity of tetanus toxin (tetX)", "R-HSA-5250992:r:Toxicity of botulinum toxin type E (botE)", "R-HSA-5250955:r:Toxicity of botulinum toxin type D (botD)", "R-HSA-5250981:r:Toxicity of botulinum toxin type F (botF)", "R-HSA-5250958:r:Toxicity of botulinum toxin type B (botB)"], "type": "Domain"}, "IPR012501": {"description": "Vacuolar protein sorting-associated protein 54, C-terminal", "go_ids": ["GO:0042147"], "go_terms": ["GO:0042147:retrograde transport, endosome to Golgi:P"], "name": "Vps54_C", "pathway_ids": ["R-DME-6811440", "R-HSA-6811440", "R-RNO-6811440", "R-MMU-6811440"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR012503": {"description": "WisP, N-terminal", "go_ids": [], "go_terms": [], "name": "WisP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012504": {"description": "Spore protein YabP", "go_ids": ["GO:0030435"], "go_terms": ["GO:0030435:sporulation resulting in formation of a cellular spore:P"], "name": "Spore_YabP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012505": {"description": "YbbR-like", "go_ids": [], "go_terms": [], "name": "YbbR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012506": {"description": "Lysoplasmalogenase-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TMEM86B-like", "pathway_ids": ["PWY-7783", "R-RNO-1482788", "R-SSC-1482788", "R-DDI-1482788", "R-BTA-1482788", "R-MMU-1482788", "R-HSA-1482788"], "pathways": ["PWY-7783:t:plasmalogen degradation", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-SSC-1482788:r:Acyl chain remodelling of PC", "R-DDI-1482788:r:Acyl chain remodelling of PC", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Family"}, "IPR012507": {"description": "YibE/F-like", "go_ids": [], "go_terms": [], "name": "YibE_F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012508": {"description": "ATPase, A1 complex, epsilon subunit, archaeal", "go_ids": ["GO:0015986", "GO:0033178", "GO:0042626"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P", "GO:0033178:proton-transporting two-sector 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{"description": "S-adenosyl-l-methionine decarboxylase leader peptide", "go_ids": [], "go_terms": [], "name": "AdoMetDC_leader", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012512": {"description": "Albumin I", "go_ids": ["GO:0045735"], "go_terms": ["GO:0045735:nutrient reservoir activity:F"], "name": "Albumin_I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012513": {"description": "Metchnikowin", "go_ids": ["GO:0019731", "GO:0019732"], "go_terms": ["GO:0019731:antibacterial humoral response:P", "GO:0019732:antifungal humoral response:P"], "name": "Mtk", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012514": {"description": "Formaecin", "go_ids": ["GO:0042381", "GO:0042742"], "go_terms": ["GO:0042381:hemolymph coagulation:P", "GO:0042742:defense response to bacterium:P"], "name": "Formaecin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012515": {"description": "Pleurocidin", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense 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"Antimicrobial_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012524": {"description": "Abaecin, antimicrobial peptide", "go_ids": ["GO:0005576", "GO:0042381"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042381:hemolymph coagulation:P"], "name": "Abaecin_antimicrobial_peptide", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012526": {"description": "Scorpion antimicrobial peptide", "go_ids": ["GO:0005576", "GO:0042742", "GO:0044179"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0042742:defense response to bacterium:P", "GO:0044179:hemolysis in another organism:P"], "name": "Antimicrobial_7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012527": {"description": "Uperin", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Antimicrobial_8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012528": {"description": "Ponericin L", "go_ids": ["GO:0005576", "GO:0045087"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0045087:innate immune response:P"], "name": "Antimicrobial_9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012529": {"description": "Attractin", "go_ids": ["GO:0000772", "GO:0005576", "GO:0019953"], "go_terms": ["GO:0000772:mating pheromone activity:F", "GO:0005576:extracellular region:C", "GO:0019953:sexual reproduction:P"], "name": "Attractin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012530": {"description": "B melanoma antigen-like", "go_ids": [], "go_terms": [], "name": "BAGE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012532": {"description": "BDHCT", "go_ids": ["GO:0003677", "GO:0005524", "GO:0005634", "GO:0006260", "GO:0016818"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F", "GO:0005634:nucleus:C", "GO:0006260:DNA replication:P", "GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F"], "name": "BDHCT", "pathway_ids": 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"R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR012575": {"description": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, NDUB1", "go_ids": ["GO:0005739"], "go_terms": ["GO:0005739:mitochondrion:C"], "name": "NDUB1", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-RNO-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-MMU-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR012576": {"description": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3", "go_ids": ["GO:0005739", "GO:0022900"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0022900:electron transport chain:P"], "name": "NDUFB3", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR012577": {"description": "NIPSNAP", "go_ids": [], "go_terms": [], "name": "NIPSNAP", "pathway_ids": ["R-CEL-9013407", "R-HSA-9013409", "R-MMU-9013407", "R-DRE-9013407", "R-HSA-9013407", "R-DME-9013407"], "pathways": ["R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-DRE-9013407:r:RHOH GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DME-9013407:r:RHOH GTPase cycle"], "type": "Domain"}, "IPR012578": {"description": "Nuclear pore complex component", "go_ids": [], "go_terms": [], "name": "Nucl_pore_cmplx", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012579": {"description": "U3 small nucleolar RNA-associated protein NOL7, C-terminal", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "NOL7_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012580": {"description": "NUC153", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "NUC153", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012582": {"description": "DNA-dependent protein kinase catalytic subunit, CC3", "go_ids": ["GO:0005634", "GO:0006303"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006303:double-strand break repair via nonhomologous end joining:P"], "name": "DNAPKcs_CC3", "pathway_ids": ["R-HSA-8866654", "R-HSA-3270619", "R-MMU-8866654", "R-HSA-5693571", "R-GGA-353423", "R-DDI-5693571", "R-GGA-351433", "R-HSA-1834949", "R-MMU-5693571"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Domain"}, "IPR012583": {"description": "Pre-rRNA-processing protein RIX1, N-terminal", "go_ids": [], "go_terms": [], "name": "RIX1_N", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-8849473", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-8849473:r:PTK6 Expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012584": {"description": "Nucleolar protein 11, N-terminal domain", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "NOL11_N", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-HSA-6790901", "R-HSA-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012585": {"description": "Anticodon nuclease activator Stp", "go_ids": ["GO:0004518", "GO:0050792"], "go_terms": ["GO:0004518:nuclease activity:F", "GO:0050792:regulation of viral process:P"], "name": "Stp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012586": {"description": "28S rRNA (cytosine-C(5))-methyltransferase repeat", "go_ids": [], "go_terms": [], "name": "NOP2_rpt", "pathway_ids": ["R-HSA-6790901", "R-HSA-8869496"], "pathways": ["R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "type": "Repeat"}, "IPR012587": {"description": "RNA helicase p68 repeat", "go_ids": [], "go_terms": [], "name": "P68_rpt", "pathway_ids": ["R-HSA-72163", "R-HSA-9694686", "R-HSA-9770562", "R-MMU-3899300", "R-MMU-9770562", "R-MMU-72163", "R-HSA-9682706", "R-HSA-3899300", "R-HSA-9918481", "R-HSA-9018519", "R-MMU-9018519"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Repeat"}, "IPR012588": {"description": "Exosome-associated factor Rrp6, N-terminal", "go_ids": ["GO:0000176", "GO:0006396"], "go_terms": ["GO:0000176:nuclear exosome (RNase complex):C", "GO:0006396:RNA processing:P"], "name": "Exosome-assoc_fac_Rrp6_N", "pathway_ids": ["R-MMU-9930044", "R-MMU-6791226", "R-HSA-9930044", "R-SCE-6791226", "R-HSA-6791226", "R-DME-9930044", "R-DME-6791226", "R-CEL-9930044", "R-CEL-6791226", "R-SPO-9930044", "R-RNO-9930044", "R-SPO-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-9930044:r:Nuclear RNA decay", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-9930044:r:Nuclear RNA decay", "R-RNO-9930044:r:Nuclear RNA decay", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012589": {"description": "Plasma membrane ATPase proteolipid", "go_ids": ["GO:0030234", "GO:0050790"], "go_terms": ["GO:0030234:enzyme regulator activity:F", "GO:0050790:regulation of catalytic activity:P"], "name": "Pmp1/Pmp2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012590": {"description": "POPLD domain", "go_ids": [], "go_terms": [], "name": "POPLD_dom", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR012591": {"description": "PRO8NT domain", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "PRO8NT", "pathway_ids": ["R-HSA-72163", "R-CEL-72165", "R-MMU-72165", "R-MMU-72163", "R-HSA-72165", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR012592": {"description": "PROCN domain", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], 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b6/f complex subunit 7", "go_ids": ["GO:0009512"], "go_terms": ["GO:0009512:cytochrome b6f complex:C"], "name": "PetM_cyt_b6/f_cplx_su7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012596": {"description": "Bacteriophage T4, Y12G", "go_ids": [], "go_terms": [], "name": "Phage_T4_Y12G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012597": {"description": "Fungal mating-type pheromone", "go_ids": ["GO:0000772", "GO:0016020"], "go_terms": ["GO:0000772:mating pheromone activity:F", "GO:0016020:membrane:C"], "name": "Pheromone", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012599": {"description": "Peptidase C1A, propeptide", "go_ids": ["GO:0004197", "GO:0050790"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0050790:regulation of catalytic activity:P"], "name": "Propeptide_C1A", "pathway_ids": ["R-MMU-1679131", "R-HSA-6798695", "R-BTA-1679131", "R-RNO-6798695", "R-SSC-6798695", "R-HSA-2132295", "R-RNO-2132295", "R-SSC-1679131", "R-RNO-2022090", "R-BTA-1442490", "R-HSA-9766229", "R-BTA-6798695", "R-RNO-1442490", "R-MMU-2022090", "R-HSA-1679131", "R-RNO-1679131", "R-SSC-2132295", "R-HSA-2022090", "R-MMU-2132295", "R-RNO-9766229", "R-MMU-6798695", "R-SSC-1442490", "R-MMU-9766229", "R-BTA-2132295", "R-HSA-1442490", "R-MMU-1442490"], "pathways": ["R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-1679131:r:Trafficking and processing of endosomal TLR", "R-RNO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-SSC-1679131:r:Trafficking and processing of endosomal TLR", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-BTA-1442490:r:Collagen degradation", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-1442490:r:Collagen degradation", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-RNO-1679131:r:Trafficking and processing of endosomal TLR", "R-SSC-2132295:r:MHC class II antigen presentation", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-9766229:r:Degradation of CDH1", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-1442490:r:Collagen degradation", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-2132295:r:MHC class II antigen presentation", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1442490:r:Collagen degradation"], "type": "Domain"}, "IPR012600": {"description": "Gingipain propeptide", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "Propeptide_C25", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012601": {"description": "Spermatozal protamine type", "go_ids": ["GO:0000228", "GO:0003677", "GO:0035092"], "go_terms": ["GO:0000228:nuclear chromosome:C", "GO:0003677:DNA binding:F", "GO:0035092:sperm DNA condensation:P"], "name": "Spermatozal_protamine_typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012602": {"description": "PyrBI operon leader peptide", "go_ids": ["GO:0019856"], "go_terms": ["GO:0019856:pyrimidine nucleobase biosynthetic process:P"], "name": "PyrBI_leader", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012603": {"description": "ARID4A/B, PWWP domain", "go_ids": [], "go_terms": [], "name": "ARID4A/B_PWWP", "pathway_ids": ["R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-RNO-3214815", "R-HSA-427413"], "pathways": ["R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-RNO-3214815:r:HDACs deacetylate histones", "R-HSA-427413:r:NoRC negatively regulates rRNA expression"], "type": "Domain"}, "IPR012604": {"description": "RBM1CTR", "go_ids": [], "go_terms": [], "name": "RBM1CTR", "pathway_ids": ["R-HSA-72203", "R-HSA-9013422", "R-HSA-9013418", "R-HSA-9770562", "R-HSA-9696270", "R-RNO-9013422", "R-RNO-72203", "R-RNO-9696270", "R-MMU-72203", "R-MMU-9770562", "R-MMU-72163", "R-RNO-72163", "R-RNO-9696273", "R-HSA-9696264", "R-HSA-72163", "R-MMU-9013422", "R-RNO-9770562", "R-RNO-9696264", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9918481", "R-HSA-9696273", "R-RNO-9013418", "R-MMU-9013418"], "pathways": ["R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9770562:r:mRNA Polyadenylation", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle"], "type": "Domain"}, "IPR012605": {"description": "RepA1 leader peptide Tap", "go_ids": [], "go_terms": [], "name": "RepA1_leader_peptide_Tap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012606": {"description": "Small ribosomal subunit protein uS15, N-terminal", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of 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"type": "Family"}, "IPR012635": {"description": "Parabutoxin", "go_ids": ["GO:0005576", "GO:0019870"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019870:potassium channel inhibitor activity:F"], "name": "Parabutoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012636": {"description": "Tamulustoxin", "go_ids": ["GO:0005576", "GO:0019870", "GO:0090729"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019870:potassium channel inhibitor activity:F", "GO:0090729:toxin activity:F"], "name": "Toxin_32", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012637": {"description": "Waglerin", "go_ids": ["GO:0005576", "GO:0030550"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0030550:acetylcholine receptor inhibitor activity:F"], "name": "Toxin_33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012638": {"description": "Tryptophan leader peptide", "go_ids": [], "go_terms": [], "name": "Trp_leader1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012639": {"description": "Tryptophan operon leader peptide", "go_ids": [], "go_terms": [], "name": "Trp_leader2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012640": {"description": "Membrane lipoprotein, lipid attachment site", "go_ids": [], "go_terms": [], "name": "Membr_lipoprot_lipid_attach_CS", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR012641": {"description": "Cysteine rich domain, Polydnavirus", "go_ids": [], "go_terms": [], "name": "Polydnavirus_Cys-rich", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012642": {"description": "Transcription regulator Wos2-domain", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Tscrpt_reg_Wos2-domain", "pathway_ids": ["R-HSA-983231", "R-HSA-9616222", "R-HSA-9834899", "R-HSA-8939236", "R-HSA-9018519", "R-HSA-5601884"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis"], "type": "Domain"}, "IPR012643": {"description": "Wound-inducible basic", "go_ids": [], "go_terms": [], "name": "Wound_ind", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012644": {"description": "Conserved hypothetical protein CHP02300, FYDLN acid", "go_ids": [], "go_terms": [], "name": "CHP02300_FYDLN_acid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012645": {"description": "Conserved hypothetical protein CHP02301", "go_ids": [], "go_terms": [], "name": "CHP02301", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012646": {"description": "RNA ligase, DRB0094", "go_ids": [], "go_terms": [], "name": "RNA_ligase_DRB0094", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012647": {"description": "RNA ligase, Rnl2", "go_ids": ["GO:0003972", "GO:0005524", "GO:0016874"], "go_terms": ["GO:0003972:RNA ligase (ATP) activity:F", "GO:0005524:ATP binding:F", "GO:0016874:ligase activity:F"], "name": "RNA_lig_RNL2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012648": {"description": "T4 RNA ligase 1", "go_ids": ["GO:0003972"], "go_terms": ["GO:0003972:RNA ligase (ATP) activity:F"], "name": "Rnl1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012649": {"description": "Phosphonopyruvate hydrolase", "go_ids": [], "go_terms": [], "name": "PPH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012650": {"description": "Conserved hypothetical protein CHP02328", "go_ids": [], "go_terms": [], "name": "CHP02328", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012651": {"description": "Thiamine transporter ThiT", "go_ids": ["GO:0015888", "GO:0005886", "GO:0015234"], "go_terms": ["GO:0015888:thiamine transport:P", "GO:0005886:plasma membrane:C", "GO:0015234:thiamine transmembrane transporter activity:F"], "name": "Thia_Transptr_ThiT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012652": {"description": "Energy coupling factor transporter S component ThiW", "go_ids": [], "go_terms": [], "name": "ThiW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012653": {"description": "Dimethylamine methyltransferase MtbB", "go_ids": ["GO:0008168", "GO:0015948"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0015948:methanogenesis:P"], "name": "Dimeth_MeTrfase_MtbB", "pathway_ids": ["PWY-5248"], "pathways": ["PWY-5248:t:methanogenesis from dimethylamine"], "type": "Family"}, "IPR012654": {"description": "Conserved hypothetical protein CHP02391", "go_ids": [], "go_terms": [], "name": "CHP02391", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012655": {"description": "Uncharacterised protein YrzI", "go_ids": [], "go_terms": [], "name": "YrzI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012656": {"description": "Conserved hypothetical protein CHP02421, QEGLA", "go_ids": [], "go_terms": [], "name": "CHP02421_QEGLA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012657": {"description": "23S rRNA-intervening sequence protein", "go_ids": [], "go_terms": [], "name": "23S_rRNA-intervening_sequence", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012658": {"description": "Uncharacterized protein YheV", "go_ids": [], "go_terms": [], "name": "YheV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012659": {"description": "Conserved hypothetical protein CHP02444", "go_ids": [], "go_terms": [], "name": "CHP02444", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012660": {"description": "Thioesterase, putative", "go_ids": [], "go_terms": [], "name": "YiiD_C", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR012661": {"description": "Conserved hypothetical protein CHP02448", "go_ids": [], "go_terms": [], "name": "CHP02448", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012662": {"description": "Conserved hypothetical protein CHP02449", "go_ids": [], "go_terms": [], "name": "CHP02449", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012663": {"description": "Conserved hypothetical protein CHP02450, tryptophan-rich", "go_ids": [], "go_terms": [], "name": "CHP02450_Tryp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012664": {"description": "Conserved hypothetical protein CHP02452", "go_ids": [], "go_terms": [], "name": "CHP02452", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012665": {"description": "Trehalose synthase", "go_ids": [], "go_terms": [], "name": "Trehalose_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012666": {"description": "Cobalt transporter subunit CbtA, putative", "go_ids": [], "go_terms": [], "name": "CbtA_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012667": {"description": "Cobalt transporter subunit CbtB, putative", "go_ids": [], "go_terms": [], "name": "CbtB_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012668": {"description": "Conserved hypothetical protein CHP02466", "go_ids": [], "go_terms": [], "name": "CHP02466", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012669": {"description": "Pectic acid lyase", 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"R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-MMU-9629569:r:Protein hydroxylation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9629569:r:Protein hydroxylation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Homologous_superfamily"}, "IPR012677": {"description": "Nucleotide-binding alpha-beta plait domain superfamily", "go_ids": [], "go_terms": [], "name": "Nucleotide-bd_a/b_plait_sf", "pathway_ids": ["R-HSA-9013405", "R-MMU-8849468", "R-HSA-6807505", "R-BTA-975957", "R-RNO-9013422", "R-CEL-72165", "R-MMU-9770562", "R-HSA-8936459", "R-HSA-9010553", "R-SPO-9930044", "R-DDI-72163", "R-XTR-113418", "R-SSC-9841922", "R-HSA-5368286", "R-CEL-9770562", "R-HSA-4570464", "R-HSA-9696273", "R-SPO-4085377", "R-HSA-450408", 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"R-DRE-3214841", "R-DME-8936459", "R-RNO-170822", "R-HSA-5687128", "R-MMU-166208", "R-CEL-1660499", "R-MMU-9634638", "R-DDI-72706", "R-DDI-9954716", "R-CEL-6803529"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9930044:r:Nuclear RNA decay", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-XTR-113418:r:Formation of the Early Elongation Complex", "R-SSC-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9696273:r:RND1 GTPase cycle", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-166208:r:mTORC1-mediated signalling", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-XTR-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-72086:r:mRNA Capping", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-9629569:r:Protein hydroxylation", "R-DME-72649:r:Translation initiation complex formation", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-9930044:r:Nuclear RNA decay", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-166208:r:mTORC1-mediated signalling", "R-MMU-72200:r:mRNA Editing: C to U Conversion", "R-MMU-429947:r:Deadenylation of mRNA", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SSC-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-XTR-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-XTR-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9696273:r:RND1 GTPase cycle", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-8951664:r:Neddylation", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-SPO-72086:r:mRNA Capping", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-75094:r:Formation of the Editosome", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-9930044:r:Nuclear RNA decay", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-SSC-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-DDI-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-72086:r:mRNA Capping", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-CEL-8941326:r:RUNX2 regulates bone development", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DDI-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-72649:r:Translation initiation complex formation", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-167161:r:HIV Transcription Initiation", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-CEL-72649:r:Translation initiation complex formation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DME-426496:r:Post-transcriptional silencing by small RNAs", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DME-429947:r:Deadenylation of mRNA", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SSC-72187:r:mRNA 3'-end processing", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-XTR-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-GGA-9770562:r:mRNA Polyadenylation", "R-SSC-6803529:r:FGFR2 alternative splicing", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-MMU-191859:r:snRNP Assembly", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SSC-9770562:r:mRNA Polyadenylation", "R-XTR-72086:r:mRNA Capping", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-1989781:r:PPARA activates gene expression", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DME-9930044:r:Nuclear RNA decay", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-191859:r:snRNP Assembly", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-SPO-9696273:r:RND1 GTPase cycle", "R-BTA-429947:r:Deadenylation of mRNA", "R-HSA-9635465:r:Suppression of apoptosis", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DRE-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-RNO-429947:r:Deadenylation of mRNA", "R-BTA-9930044:r:Nuclear RNA decay", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-6782135:r:Dual incision in TC-NER", "R-RNO-9696270:r:RND2 GTPase cycle", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-GGA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-75094:r:Formation of the Editosome", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-DRE-9930044:r:Nuclear RNA decay", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-DME-72086:r:mRNA Capping", "R-HSA-72200:r:mRNA Editing: C to U Conversion", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-75953:r:RNA 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"R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-9696264:r:RND3 GTPase cycle", "R-DME-5389840:r:Mitochondrial translation elongation", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-SCE-429947:r:Deadenylation of mRNA", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-428359:r:Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind 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"R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins"], "type": "Family"}, "IPR012778": {"description": "Peptidase M1, aminopeptidase", "go_ids": ["GO:0006508", "GO:0004177"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0004177:aminopeptidase activity:F"], "name": "Pept_M1_aminopeptidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012779": {"description": "Peptidase M1, alanyl aminopeptidase", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Peptidase_M1_pepN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012780": {"description": "Carbon-monoxide dehydrogenase, large subunit", "go_ids": ["GO:0043885", "GO:0005507", "GO:0030151"], "go_terms": ["GO:0043885:anaerobic carbon-monoxide dehydrogenase activity:F", "GO:0005507:copper ion binding:F", "GO:0030151:molybdenum ion binding:F"], "name": 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(engineered)", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-5137:t:fatty acid beta-oxidation III (unsaturated, odd number)", "PWY-7094:t:fatty acid salvage", "PWY-8179:t:platensimycin biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5177:t:glutaryl-CoA degradation", "PWY-7779:t:methyl tert-butyl ether degradation"], "type": "Family"}, "IPR012800": {"description": "Catechol 1,2-dioxygenase, actinobacteria", "go_ids": [], "go_terms": [], "name": "Cchol_dOase_actb", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012801": {"description": "Catechol 1,2-dioxygenase, proteobacteria", "go_ids": ["GO:0005506", "GO:0018576", "GO:0019614"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0018576:catechol 1,2-dioxygenase activity:F", "GO:0019614:catechol-containing compound catabolic process:P"], "name": "Cchol_dOase_prob", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012802": {"description": "Fatty 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"PWY-6435:t:4-hydroxybenzoate biosynthesis III (plants)", "PWY-6443:t:benzoate biosynthesis I (CoA-dependent, beta-oxidative)", "PWY-6583:t:pyruvate fermentation to butanol I", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-6458:t:benzoyl-CoA biosynthesis", "PWY-6446:t:benzoate biosynthesis III (CoA-dependent, non-beta-oxidative)", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-1361:t:benzoyl-CoA degradation I (aerobic)", "PWY-7778:t:2-methylpropene degradation", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-5138:t:fatty acid beta-oxidation IV (unsaturated, even number)", "PWY-8347:t:adipate biosynthesis", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7094:t:fatty acid salvage", "PWY-8179:t:platensimycin biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5177:t:glutaryl-CoA degradation", "PWY-7779:t:methyl tert-butyl ether degradation"], "type": "Family"}, "IPR012803": {"description": "Fatty acid oxidation complex, alpha subunit, mitochondrial", "go_ids": ["GO:0003857", "GO:0004300", "GO:0005739", "GO:0006635", "GO:0016507"], "go_terms": ["GO:0003857:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity:F", "GO:0004300:enoyl-CoA hydratase activity:F", "GO:0005739:mitochondrion:C", "GO:0006635:fatty acid beta-oxidation:P", "GO:0016507:mitochondrial fatty acid beta-oxidation multienzyme complex:C"], "name": "Fa_ox_alpha_mit", "pathway_ids": ["PWY-7045", "PWY-8182", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-6443", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7726", "PWY-7706", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8181", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-7654", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-8179", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7007", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-6458", "PWY-7735", "PWY-5284", "PWY-6446", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-5136", "PWY-8116", "PWY-7988", "PWY-1361", "PWY-7601", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-8354", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-5138", "PWY-8347", "PWY-8371", "PWY-5268", "PWY-7461", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-RNO-1482798", "R-SSC-77348", "R-RNO-77346", "R-HSA-77288", "R-SSC-77350", "R-MMU-77350", "R-RNO-77310", "R-SSC-1482798", "R-HSA-77350", "R-HSA-77348", "R-MMU-77348", "R-HSA-77285", "R-HSA-1482798", "R-HSA-77346", "R-MMU-77285", "R-SSC-77346", "R-RNO-77305", "R-SSC-77310", "R-MMU-77346", "R-RNO-77350", "R-RNO-77285", "R-MMU-77305", "R-HSA-77310", "R-SSC-77285", "R-MMU-77310", "R-RNO-77348", "R-MMU-1482798", "R-HSA-77305", "R-SSC-77305"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-8182:t:valproate beta-oxidation", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-6443:t:benzoate biosynthesis I (CoA-dependent, beta-oxidative)", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-6458:t:benzoyl-CoA biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-6446:t:benzoate biosynthesis III (CoA-dependent, non-beta-oxidative)", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-1361:t:benzoyl-CoA degradation I (aerobic)", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-8354:t:adipate degradation", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-5138:t:fatty acid beta-oxidation IV (unsaturated, even number)", "PWY-8347:t:adipate biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-RNO-1482798:r:Acyl chain remodeling of CL", "R-SSC-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-SSC-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-SSC-1482798:r:Acyl chain remodeling of CL", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-SSC-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-SSC-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "type": "Family"}, "IPR012804": {"description": "Cobaltochelatase subunit, putative", "go_ids": [], "go_terms": [], "name": "Cob_chelat_sub_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012805": {"description": "Acetyl-CoA C-acyltransferase FadA", "go_ids": ["GO:0003988", "GO:0005737", "GO:0006631", "GO:0016042"], "go_terms": ["GO:0003988:acetyl-CoA C-acyltransferase activity:F", "GO:0005737:cytoplasm:C", "GO:0006631:fatty acid metabolic process:P", "GO:0016042:lipid catabolic process:P"], "name": "FadA", "pathway_ids": ["PWY-8182", "PWY-7339", "PWY-735", "PWY-7338", "PWY-6435", "PWY-6443", "PWY-6946", "PWY-481", "PWY-8181", "PWY-6945", "PWY-8463", "PWY-6458", "PWY-7948", "PWY-8152", "PWY-6948", "PWY-7340", "PWY-7726", "PWY-6944", "PWY-7288", "PWY-7654", "PWY-5109", "PWY-5136", "PWY-7337", "PWY-7094", "PWY-8179", "PWY-7606", "PWY-6080"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-6435:t:4-hydroxybenzoate biosynthesis III (plants)", "PWY-6443:t:benzoate biosynthesis I (CoA-dependent, beta-oxidative)", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-481:t:ethylbenzene degradation (anaerobic)", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-6458:t:benzoyl-CoA biosynthesis", "PWY-7948:t:4-oxopentanoate degradation", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-7094:t:fatty acid salvage", "PWY-8179:t:platensimycin biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-6080:t:4-ethylphenol degradation (anaerobic)"], "type": "Family"}, "IPR012806": {"description": "Acetyl-CoA C-acyltransferase FadI", "go_ids": ["GO:0005737", "GO:0006631", "GO:0016042", "GO:0003988"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006631:fatty acid metabolic process:P", "GO:0016042:lipid catabolic process:P", "GO:0003988:acetyl-CoA C-acyltransferase activity:F"], "name": "Ac-CoA_C-AcTrfase_FadI", "pathway_ids": ["PWY-8182", "PWY-7339", "PWY-735", "PWY-7338", "PWY-6435", "PWY-6443", "PWY-6946", "PWY-481", "PWY-8181", "PWY-6945", "PWY-8463", "PWY-6458", "PWY-7948", "PWY-8152", "PWY-6948", "PWY-7340", "PWY-7726", "PWY-6944", "PWY-7288", "PWY-7654", "PWY-5109", "PWY-5136", "PWY-7337", "PWY-7094", "PWY-8179", "PWY-7606", "PWY-6080"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-6435:t:4-hydroxybenzoate biosynthesis III (plants)", "PWY-6443:t:benzoate biosynthesis I (CoA-dependent, beta-oxidative)", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-481:t:ethylbenzene degradation (anaerobic)", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-6458:t:benzoyl-CoA biosynthesis", "PWY-7948:t:4-oxopentanoate degradation", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-7094:t:fatty acid salvage", "PWY-8179:t:platensimycin biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-6080:t:4-ethylphenol degradation (anaerobic)"], "type": "Family"}, "IPR012807": {"description": "Anti-sigma-E factor ChrR", "go_ids": [], "go_terms": [], "name": "Anti-sigma_ChrR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012808": {"description": "Conserved hypothetical protein CHP02453", "go_ids": [], "go_terms": [], "name": "CHP02453", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012809": {"description": "Cobalt ECF transporter T component CbiQ", "go_ids": ["GO:0043190", "GO:0005886", "GO:0006824"], "go_terms": ["GO:0043190:ATP-binding cassette (ABC) transporter complex:C", "GO:0005886:plasma membrane:C", "GO:0006824:cobalt ion transport:P"], "name": "ECF_CbiQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012810": {"description": "Trehalose synthase/alpha-amylase, N-terminal", "go_ids": ["GO:0003824", "GO:0005975"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "TreS/a-amylase_N", "pathway_ids": ["PWY-7900", "PWY-2622", "R-MTU-868688"], "pathways": ["PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)", "PWY-2622:t:trehalose biosynthesis IV", "R-MTU-868688:r:Trehalose biosynthesis"], "type": "Domain"}, "IPR012811": {"description": "Trehalose synthase/probable maltokinase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TreS_maltokin_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012812": {"description": "Mannosyl-3-phosphoglycerate synthase", "go_ids": ["GO:0005737", "GO:0050504", "GO:0051479"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0050504:mannosyl-3-phosphoglycerate synthase activity:F", "GO:0051479:mannosylglycerate biosynthetic process:P"], "name": "Osmo_MPG_synth", "pathway_ids": ["PWY-5656"], "pathways": ["PWY-5656:t:mannosylglycerate biosynthesis I"], "type": "Family"}, "IPR012814": {"description": "Pyranose 2-oxidase", "go_ids": ["GO:0050233", "GO:0050660"], "go_terms": ["GO:0050233:pyranose oxidase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "P2OX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012816": {"description": "NADAR", "go_ids": [], "go_terms": [], "name": "NADAR", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Domain"}, "IPR012817": {"description": "Chlorocatechol 1,2-dioxygenase", "go_ids": ["GO:0005506"], "go_terms": ["GO:0005506:iron ion binding:F"], "name": "Chlorcchol_dOase", "pathway_ids": ["PWY-6069", "PWY-5642", "PWY-6339", "PWY-6094", "PWY-7557", "PWY-6089", "PWY-8019", "PWY-7734", "PWY-7682", "PWY-6193", "PWY-5163", "PWY-8362", "PWY-6102", "PWY-8363", "PWY-6093", "PWY-6068", "PWY-6667", "PWY-8407", "PWY-8432", "PWY-7006", "PWY-6178", "PWY-7733", "PWY-7010", "PWY-7582", "PWY-6084", "PWY-6087", "PWY-181", "PWY-7009", "PWY-6107", "PWY-7011", "PWY-8431", "PWY-8260", "PWY-721", "PWY-6190", "PWY-8397", "PWY-8269", "PWY-6336"], "pathways": ["PWY-6069:t:indigo biosynthesis", "PWY-5642:t:2,4-dinitrotoluene degradation", "PWY-6339:t:syringate degradation", "PWY-6094:t:3,4,6-trichlorocatechol degradation", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-6089:t:3-chlorocatechol degradation I (ortho)", "PWY-8019:t:2-hydroxyparaconate and itatartarate biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7682:t:arabidopyrone biosynthesis", "PWY-6193:t:3-chlorocatechol degradation II (ortho)", "PWY-5163:t:p-cumate degradation to 2-hydroxypentadienoate", "PWY-8362:t:photorespiration II", "PWY-6102:t:5-chloro-3-methyl-catechol degradation", "PWY-8363:t:photorespiration III", "PWY-6093:t:4,5-dichlorocatechol degradation", "PWY-6068:t:indican biosynthesis", "PWY-6667:t:resveratrol degradation", "PWY-8407:t:fumagillin biosynthesis", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-7006:t:4-amino-3-hydroxybenzoate degradation", "PWY-6178:t:2,4,6-trichlorophenol degradation", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7010:t:2-propylphenol degradation", "PWY-7582:t:mercaptosuccinate degradation", "PWY-6084:t:3,5-dichlorocatechol degradation", "PWY-6087:t:4-chlorocatechol degradation", "PWY-181:t:photorespiration I", "PWY-7009:t:2,2'-dihydroxybiphenyl degradation", "PWY-6107:t:chlorosalicylate degradation", "PWY-7011:t:2-isopropylphenol degradation", "PWY-8431:t:L-mimosine degradation", "PWY-8260:t:roxarsone degradation I", "PWY-721:t:3-methylquinoline degradation", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8269:t:methylarsonous acid detoxification III", "PWY-6336:t:protocatechuate degradation III (para-cleavage pathway)"], "type": "Family"}, "IPR012818": {"description": "Precorrin-6Y methyltransferase", "go_ids": ["GO:0008276", "GO:0009236"], "go_terms": ["GO:0008276:protein methyltransferase activity:F", "GO:0009236:cobalamin biosynthetic process:P"], "name": "CbiE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012819": {"description": "Sucrose-phosphate synthase, plant", "go_ids": ["GO:0005985", "GO:0046524"], "go_terms": ["GO:0005985:sucrose metabolic process:P", "GO:0046524:sucrose-phosphate synthase activity:F"], "name": "SPS_pln", "pathway_ids": ["PWY-7238", "PWY-7347"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-7347:t:sucrose biosynthesis III"], "type": "Family"}, "IPR012820": {"description": "Sucrose synthase, plant/cyanobacteria", "go_ids": ["GO:0016157", "GO:0005985"], "go_terms": ["GO:0016157:sucrose synthase activity:F", "GO:0005985:sucrose metabolic process:P"], "name": "Sucrose_synthase_pln/cyn", "pathway_ids": ["PWY-3801"], "pathways": ["PWY-3801:t:sucrose degradation II (sucrose synthase)"], "type": "Family"}, "IPR012821": {"description": "Sucrose phosphate synthase, sucrose phosphatase-like domain", "go_ids": [], "go_terms": [], "name": "Sucrose_P_synth_Pase-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012822": {"description": "Sucrose-phosphate synthase, glycosyltransferase domain", "go_ids": [], "go_terms": [], "name": "SucroseP_synth_GlycoTrfase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012823": {"description": "Flagellar export FliJ", "go_ids": ["GO:0071973", "GO:0009288"], "go_terms": ["GO:0071973:bacterial-type flagellum-dependent cell motility:P", "GO:0009288:bacterial-type flagellum:C"], "name": "Flagell_FliJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012824": {"description": "Zinc chaperone CobW", "go_ids": ["GO:0009236"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P"], "name": "CobW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012825": {"description": "5,6-dimethylbenzimidazole synthase BluB", "go_ids": [], "go_terms": [], "name": "BluB", "pathway_ids": ["PWY-5523"], "pathways": ["PWY-5523:t:5,6-dimethylbenzimidazole biosynthesis I (aerobic)"], "type": "Family"}, "IPR012826": {"description": "Flagellar motor switch FliN", "go_ids": ["GO:0006935", "GO:0016020", "GO:0009288", "GO:0071973"], "go_terms": ["GO:0006935:chemotaxis:P", "GO:0016020:membrane:C", "GO:0009288:bacterial-type flagellum:C", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "FliN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012827": {"description": "Hemerythrin, metal-binding domain", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Hemerythrin_metal-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012828": {"description": "ATP-dependent 6-phosphofructokinase, prokaryotic", "go_ids": ["GO:0003872", "GO:0005524", "GO:0006002", "GO:0006096"], "go_terms": ["GO:0003872:6-phosphofructokinase activity:F", "GO:0005524:ATP binding:F", "GO:0006002:fructose 6-phosphate metabolic process:P", "GO:0006096:glycolytic process:P"], "name": "PFKA_ATP_prok", "pathway_ids": ["PWY-5484", "PWY-1861", "PWY-1042", "PWY-7385"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1042:t:glycolysis IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)"], "type": "Family"}, "IPR012829": {"description": "Phosphofructokinase, mixed-substrate PFK group III", "go_ids": ["GO:0006096", "GO:0047334"], "go_terms": ["GO:0006096:glycolytic process:P", "GO:0047334:diphosphate-fructose-6-phosphate 1-phosphotransferase activity:F"], "name": "Phosphofructokinase_III", "pathway_ids": ["PWY-5484", "PWY-1861", "PWY-1042", "PWY-7385"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1042:t:glycolysis IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)"], "type": "Family"}, "IPR012830": {"description": "Citrate utilization protein B", "go_ids": [], "go_terms": [], "name": "CitB", "pathway_ids": ["PWY-5748"], "pathways": ["PWY-5748:t:gamma-coniciene and coniine biosynthesis"], "type": "Family"}, "IPR012831": {"description": "Tricarballylate dehydrogenase", "go_ids": [], "go_terms": [], "name": "TcuA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012832": {"description": "Reductive dehalogenase", "go_ids": [], "go_terms": [], "name": "RDH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012833": {"description": "Ribonucleoside-triphosphate reductase, anaerobic", "go_ids": ["GO:0008998", "GO:0016491", "GO:0006260"], "go_terms": ["GO:0008998:ribonucleoside-triphosphate reductase (thioredoxin) activity:F", "GO:0016491:oxidoreductase activity:F", "GO:0006260:DNA replication:P"], "name": "NrdD", "pathway_ids": ["PWY-7222", "PWY-7220", "PWY-7187"], "pathways": ["PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II"], "type": "Family"}, "IPR012834": {"description": "Flagellar basal-body rod FlgG", "go_ids": ["GO:0071973", "GO:0009426"], "go_terms": ["GO:0071973:bacterial-type flagellum-dependent cell motility:P", "GO:0009426:bacterial-type flagellum basal body, distal rod:C"], "name": "FlgG_G_neg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012835": {"description": "Flagellar hook FlgE", "go_ids": ["GO:0009288", "GO:0044781"], "go_terms": ["GO:0009288:bacterial-type flagellum:C", "GO:0044781:bacterial-type flagellum organization:P"], "name": "FlgE_epsilon", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012836": {"description": "Flagellar basal-body rod FlgF", "go_ids": ["GO:0071973", "GO:0030694"], "go_terms": ["GO:0071973:bacterial-type flagellum-dependent cell motility:P", "GO:0030694:bacterial-type flagellum basal body, rod:C"], "name": "FlgF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012837": {"description": "Ribonucleoside-triphosphate reductase activating, anaerobic", "go_ids": ["GO:0043365", "GO:0051539"], "go_terms": ["GO:0043365:[formate-C-acetyltransferase]-activating enzyme activity:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "NrdG", "pathway_ids": ["PWY-6530"], "pathways": ["PWY-6530:t:perchlorate reduction"], "type": "Family"}, "IPR012838": {"description": "Pyruvate formate-lyase 1 activating enzyme", "go_ids": ["GO:0043365"], "go_terms": ["GO:0043365:[formate-C-acetyltransferase]-activating enzyme activity:F"], "name": "PFL1_activating", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012839": {"description": "Organic radical enzyme activase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Organic_radical_activase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012840": {"description": "Anaerobic ribonucleoside-triphosphate reductase activating protein", "go_ids": [], "go_terms": [], "name": "NrdG2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012842": {"description": "Type 3 secretion system stator protein SctL/SctL2", "go_ids": ["GO:0030254"], "go_terms": ["GO:0030254:protein secretion by the type III secretion system:P"], "name": "T3SS_SctL/SctL2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012843": {"description": "YscD", "go_ids": [], "go_terms": [], "name": "YscD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012844": {"description": "Dihydroxyacetone kinase phosphotransferase subunit, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DhaM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012845": {"description": "RNA polymerase sigma factor, FliA/WhiG", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006352", "GO:0016987", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0016987:sigma factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RNA_pol_sigma_FliA_WhiG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012846": {"description": "Acetolactate synthase, large subunit, biosynthetic", "go_ids": ["GO:0000287", "GO:0003984", "GO:0009082", "GO:0030976", "GO:0050660"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0003984:acetolactate synthase activity:F", "GO:0009082:branched-chain amino acid biosynthetic process:P", "GO:0030976:thiamine pyrophosphate binding:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "Acetolactate_synth_lsu", "pathway_ids": ["PWY-7111", "PWY-6389", "PWY-5938", "PWY-5101", "PWY-5103", "PWY-5104", "PWY-5939"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-6389:t:pyruvate fermentation to (S)-acetoin", "PWY-5938:t:pyruvate fermentation to (R)-acetoin I", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-5103:t:L-isoleucine biosynthesis III", "PWY-5104:t:L-isoleucine biosynthesis IV", "PWY-5939:t:pyruvate fermentation to (R)-acetoin II"], "type": "Family"}, "IPR012847": {"description": "Sucrose phosphatase, plant/cyanobacteria", "go_ids": ["GO:0000287", "GO:0005986", "GO:0050307"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0005986:sucrose biosynthetic process:P", "GO:0050307:sucrose-phosphate phosphatase activity:F"], "name": "Sucrose_phosphatase_pln/cyn", "pathway_ids": ["PWY-7238", "PWY-7347"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-7347:t:sucrose biosynthesis III"], "type": "Family"}, "IPR012848": {"description": "Aspartic peptidase, N-terminal", "go_ids": ["GO:0004190", "GO:0006508"], "go_terms": ["GO:0004190:aspartic-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Aspartic_peptidase_N", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-MMU-77387", "R-HSA-2132295", "R-RNO-2132295", "R-HSA-77387", "R-RNO-2022377", "R-CFA-77387", "R-CFA-1442490", "R-HSA-2022377", "R-CEL-2132295", "R-CEL-5683826", "R-RNO-1442490", "R-RNO-77387", "R-CFA-2022377", "R-CFA-5683826", "R-HSA-5683826", "R-MMU-2132295", "R-MMU-6798695", "R-CFA-2132295", "R-CFA-6798695", "R-SSC-5683826", "R-MMU-1442490", "R-HSA-9018519", "R-HSA-1442490", "R-MMU-2022377"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CFA-77387:r:Insulin receptor recycling", "R-CFA-1442490:r:Collagen degradation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CEL-2132295:r:MHC class II antigen presentation", "R-CEL-5683826:r:Surfactant metabolism", "R-RNO-1442490:r:Collagen degradation", "R-RNO-77387:r:Insulin receptor recycling", "R-CFA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CFA-5683826:r:Surfactant metabolism", "R-HSA-5683826:r:Surfactant metabolism", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-2132295:r:MHC class II antigen presentation", "R-CFA-6798695:r:Neutrophil degranulation", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-1442490:r:Collagen degradation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-1442490:r:Collagen degradation", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Domain"}, "IPR012849": {"description": "Abl-interactor, homeo-domain homologous domain", "go_ids": [], "go_terms": [], "name": "Abl-interactor_HHR_dom", "pathway_ids": ["R-HSA-5663213", "R-HSA-9664422", "R-RNO-9013149", "R-HSA-2029482", "R-MMU-9013404", "R-MMU-4420097", "R-MMU-2029482", "R-RNO-2029482", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-4420097", "R-MMU-5663213", "R-RNO-5663213", "R-RNO-9013423", "R-RNO-9013404", "R-MMU-9013149", "R-RNO-4420097"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR012850": {"description": "Alpha-amylase, C-terminal beta-sheet", "go_ids": ["GO:0004556", "GO:0005509", "GO:0005975"], "go_terms": ["GO:0004556:alpha-amylase activity:F", "GO:0005509:calcium ion binding:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "A-amylase_bs_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012851": {"description": "Spore coat protein CotF-like", "go_ids": [], "go_terms": [], "name": "Spore_coat_CotF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012852": {"description": "Calcium binding and coiled-coil domain-like", "go_ids": [], "go_terms": [], "name": "CALCOCO1-like", "pathway_ids": ["R-RNO-936440", "R-MMU-936440", "R-RNO-5357905", "R-HSA-936440", "R-HSA-5357905", "R-BTA-936440", "R-BTA-5357905", "R-MMU-5357905"], "pathways": ["R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling"], "type": "Domain"}, "IPR012853": {"description": "Chloramphenicol phosphotransferase-like", "go_ids": ["GO:0005524", "GO:0016740"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016740:transferase activity:F"], "name": "CPT", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR012854": {"description": "Copper amine oxidase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Cu_amine_oxidase-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012856": {"description": "D-aminopeptidase, domain B", "go_ids": ["GO:0004177"], "go_terms": ["GO:0004177:aminopeptidase activity:F"], "name": "DAP_B_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012858": {"description": "Dendritic cell-specific transmembrane protein-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "DC_STAMP-like", "pathway_ids": ["R-HSA-8874211"], "pathways": ["R-HSA-8874211:r:CREB3 factors activate genes"], "type": "Domain"}, "IPR012859": {"description": "Archaeal Type IV pilin, N-terminal", "go_ids": [], "go_terms": [], "name": "Pilin_N_archaeal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012860": {"description": "Arf3-interacting protein 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Afi1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012861": {"description": "Protein of unknown function DUF1634", "go_ids": [], "go_terms": [], "name": "DUF1634", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012862": {"description": "Protein of unknown function DUF1635", "go_ids": [], "go_terms": [], "name": "DUF1635", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012863": {"description": "Protein of unknown function DUF1636", "go_ids": [], "go_terms": [], "name": "DUF1636", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012864": {"description": "Cysteine oxygenase/2-aminoethanethiol dioxygenase", "go_ids": ["GO:0016702"], "go_terms": ["GO:0016702:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen:F"], "name": "PCO/ADO", "pathway_ids": ["PWY-5331", "R-HSA-1614558", "R-MMU-1614558", "R-DDI-1614558"], "pathways": ["PWY-5331:t:taurine biosynthesis I", "R-HSA-1614558:r:Degradation of cysteine and homocysteine", "R-MMU-1614558:r:Degradation of cysteine and homocysteine", "R-DDI-1614558:r:Degradation of cysteine and homocysteine"], "type": "Family"}, "IPR012865": {"description": "Protein of unknown function DUF1642", "go_ids": [], "go_terms": [], "name": "DUF1642", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012866": {"description": "Protein of unknown function DUF1644", "go_ids": [], "go_terms": [], "name": "DUF1644", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012867": {"description": "Domain of unknown function DUF1648", "go_ids": [], "go_terms": [], "name": "DUF1648", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012869": {"description": "CopG-like ribbon-helix-helix domain", "go_ids": [], "go_terms": [], "name": "RHH_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012870": {"description": "Protein of unknown function DUF1666", "go_ids": [], "go_terms": [], "name": "DUF1666", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012871": {"description": "Protein of unknown function DUF1677, Oryza sativa", "go_ids": [], "go_terms": [], "name": "DUF1668_ORYSA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012872": {"description": "Protein of unknown function DUF1670", "go_ids": [], "go_terms": [], "name": "DUF1670", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012873": {"description": "Protein of unknown function DUF1672", "go_ids": [], "go_terms": [], "name": "DUF1672", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012874": {"description": "Protein of unknown function DUF1673, Methanosarcina species", "go_ids": [], "go_terms": [], "name": "DUF1673_METspp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012875": {"description": "Succinate dehydrogenase assembly factor 4", "go_ids": [], "go_terms": [], "name": "SDHF4", "pathway_ids": ["R-DDI-9854311", "R-DME-9854311", "R-HSA-9854311", "R-MMU-9854311", "R-SPO-9854311", "R-SCE-9854311"], "pathways": ["R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Family"}, "IPR012876": {"description": "Protein of unknown function DUF1677, plant", "go_ids": [], "go_terms": [], "name": "DUF1677_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012877": {"description": "Uncharacterised oxidoreductase Dhs-27", "go_ids": [], "go_terms": [], "name": "Dhs-27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012878": {"description": "Non-reducing end beta-L-arabinofuranosidase-like, GH127 catalytic domain", "go_ids": [], "go_terms": [], "name": "Beta-AFase-like_GH127_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012879": {"description": "PAT complex subunit CCDC47", "go_ids": ["GO:0005783", "GO:0005509", "GO:0032469"], "go_terms": ["GO:0005783:endoplasmic reticulum:C", "GO:0005509:calcium ion binding:F", "GO:0032469:endoplasmic reticulum calcium ion homeostasis:P"], "name": "CCDC47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012881": {"description": "Protein of unknown function DUF1685", "go_ids": [], "go_terms": [], "name": "DUF1685", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012882": {"description": "Putative redox protein Fmp46", "go_ids": ["GO:0005739", "GO:0016491"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0016491:oxidoreductase activity:F"], "name": "Fmp46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012883": {"description": "ERp29, N-terminal", "go_ids": ["GO:0005788", "GO:0009306"], "go_terms": ["GO:0005788:endoplasmic reticulum lumen:C", "GO:0009306:protein secretion:P"], "name": "ERp29_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012884": {"description": "Excisionase-like", "go_ids": ["GO:0003677", "GO:0006310"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006310:DNA recombination:P"], "name": "Excisionase-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012885": {"description": "Sdz-33, F-box domain", "go_ids": [], "go_terms": [], "name": "F-box_Sdz-33", "pathway_ids": ["R-CEL-983168", "R-CEL-4641258"], "pathways": ["R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-4641258:r:Degradation of DVL"], "type": "Domain"}, "IPR012886": {"description": "Formiminotransferase, N-terminal subdomain", "go_ids": ["GO:0005542", "GO:0016740"], "go_terms": ["GO:0005542:folic acid binding:F", "GO:0016740:transferase activity:F"], "name": "Formiminotransferase_N", "pathway_ids": ["PWY-5030", "R-MMU-70921", "R-RNO-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Domain"}, "IPR012887": {"description": "GDP-fucose pyrophosphorylase domain", "go_ids": ["GO:0016772"], "go_terms": ["GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "GDP_fucose_pyrophosphorylase", "pathway_ids": ["PWY-6", "R-HSA-6787639", "R-MMU-6787639"], "pathways": ["PWY-6:t:GDP-L-fucose biosynthesis II (from L-fucose)", "R-HSA-6787639:r:GDP-fucose biosynthesis", "R-MMU-6787639:r:GDP-fucose biosynthesis"], "type": "Domain"}, "IPR012888": {"description": "L-fucose isomerase, N-terminal-1", "go_ids": ["GO:0005737", "GO:0006004", "GO:0008736"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006004:fucose metabolic process:P", "GO:0008736:L-fucose isomerase activity:F"], "name": "Fucose_iso_N1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012889": {"description": "L-fucose isomerase, N-terminal-2", "go_ids": ["GO:0005737", "GO:0006004", "GO:0008736"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006004:fucose metabolic process:P", "GO:0008736:L-fucose isomerase activity:F"], "name": "Fucose_isomerase_N2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012890": {"description": "Intron Large complex component GCFC2-like", "go_ids": ["GO:0003677", "GO:0005634", "GO:0000398"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0000398:mRNA splicing, via spliceosome:P"], "name": "GCFC2-like", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR012891": {"description": "GCK domain", "go_ids": [], "go_terms": [], "name": "GCK_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012892": {"description": "Gp58-like", "go_ids": [], "go_terms": [], "name": "Gp58", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012893": {"description": "HipA-like, C-terminal", "go_ids": [], "go_terms": [], "name": "HipA-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012896": {"description": "Integrin beta subunit, tail", "go_ids": [], "go_terms": [], "name": "Integrin_bsu_tail", "pathway_ids": ["R-DME-2173789", "R-HSA-8874081", "R-MMU-210991", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-MMU-9013408", "R-MMU-210990", "R-CEL-3000178", "R-HSA-9856532", "R-MMU-445355", "R-CEL-1566948", "R-DME-445355", "R-MMU-3000170", "R-CEL-446343", "R-RNO-9634597", "R-RNO-210990", "R-DME-446343", "R-MMU-202733", "R-CEL-198933", "R-HSA-8875513", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-446107", "R-HSA-6802955", "R-HSA-210991", "R-RNO-446343", "R-DME-9013149", "R-HSA-6802948", "R-DME-210991", "R-RNO-445144", "R-RNO-1566977", "R-BTA-1566948", "R-DME-114608", "R-MMU-9634597", "R-CEL-5674135", "R-HSA-9609690", "R-HSA-447041", "R-DME-216083", "R-MMU-9013423", "R-HSA-2022090", "R-MMU-216083", "R-HSA-445144", "R-MMU-354192", "R-MMU-9860927", "R-MMU-446107", "R-HSA-9656223", "R-HSA-9634597", "R-MMU-5674135", "R-RNO-216083", "R-RNO-9860927", "R-HSA-9013423", "R-RNO-8874081", "R-HSA-114608", "R-MMU-8874081", "R-RNO-354192", "R-CEL-354192", "R-RNO-5674135", "R-BTA-2129379", "R-RNO-2173789", "R-CEL-9013423", "R-MMU-3000157", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-3000170", "R-MMU-1566977", "R-DME-202733", "R-RNO-446107", "R-DME-6798695", "R-DME-446107", "R-MMU-354194", "R-MMU-1236973", "R-RNO-9013423", "R-CEL-445355", "R-HSA-5663220", "R-MMU-9013149", "R-RNO-3000170", "R-BTA-216083", "R-HSA-202733", "R-HSA-6798695", "R-HSA-5674135", "R-HSA-166016", "R-DME-198933", "R-CEL-6798695", "R-CEL-354194", "R-BTA-6798695", "R-RNO-3000157", "R-RNO-9013149", "R-MMU-4420097", "R-MMU-9013404", "R-HSA-9927418", "R-BTA-2173789", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-HSA-446343", "R-RNO-202733", "R-CEL-202733", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-3000178", "R-HSA-2173789", "R-CEL-216083", "R-BTA-198933", "R-CEL-9860927", "R-RNO-198933", "R-CEL-1236973", "R-MMU-166016", "R-CEL-114608", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-RNO-1566948", "R-DME-354192", "R-BTA-166016", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-75892", "R-MMU-198933", "R-DME-445144", "R-HSA-198933", "R-MMU-8875513", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-372708", "R-RNO-4420097", "R-MMU-114608", "R-HSA-9725554", "R-HSA-3000157", "R-CEL-1566977", "R-BTA-3000178", "R-HSA-1566948", "R-DME-9860927", "R-RNO-354194", "R-RNO-2129379", "R-CEL-9013149", "R-RNO-114608", "R-BTA-202733", "R-MMU-372708", "R-HSA-210990", "R-RNO-8875513", "R-DME-1236973", "R-HSA-416700", "R-HSA-6802946", "R-DME-2129379", "R-HSA-9938206", "R-MMU-446343", "R-HSA-354192", "R-CEL-210991", "R-HSA-216083", "R-HSA-445355", "R-RNO-210991", "R-CEL-445144", "R-HSA-1566977", "R-HSA-9927432", "R-HSA-354194", "R-HSA-9679191", "R-HSA-9830674", "R-DME-3000170", "R-CEL-4420097", "R-DME-9013423", "R-MMU-2129379"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-445355:r:Smooth Muscle Contraction", "R-CEL-1566948:r:Elastic fibre formation", "R-DME-445355:r:Smooth Muscle Contraction", "R-MMU-3000170:r:Syndecan interactions", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-9634597:r:GPER1 signaling", "R-RNO-210990:r:PECAM1 interactions", "R-DME-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-210991:r:Basigin interactions", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-1566977:r:Fibronectin matrix formation", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-447041:r:CHL1 interactions", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000157:r:Laminin interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-1566948:r:Elastic fibre formation", "R-DME-354192:r:Integrin signaling", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-CEL-1566977:r:Fibronectin matrix formation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-1566948:r:Elastic fibre formation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-354192:r:Integrin signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-210991:r:Basigin interactions", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR012897": {"description": "Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain", "go_ids": ["GO:0005249", "GO:0006813", "GO:0016020", "GO:0030955"], "go_terms": ["GO:0005249:voltage-gated potassium channel activity:F", "GO:0006813:potassium ion transport:P", "GO:0016020:membrane:C", "GO:0030955:potassium ion binding:F"], "name": "K_chnl_volt-dep_Kv1.4_TID", "pathway_ids": ["R-RNO-1296072", "R-HSA-1296072", "R-MMU-1296072"], "pathways": ["R-RNO-1296072:r:Voltage gated Potassium channels", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-MMU-1296072:r:Voltage gated Potassium channels"], "type": "Domain"}, "IPR012899": {"description": "LTXXQ motif family protein", "go_ids": ["GO:0042597"], "go_terms": ["GO:0042597:periplasmic space:C"], "name": "LTXXQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012900": {"description": "G-box binding protein, multifunctional mosaic region", "go_ids": [], "go_terms": [], "name": "MFMR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012901": {"description": "Carnosine N-methyltransferase", "go_ids": ["GO:0008757"], "go_terms": ["GO:0008757:S-adenosylmethionine-dependent methyltransferase activity:F"], "name": "CARME", "pathway_ids": ["R-MMU-70921", "R-RNO-70921", "R-GGA-70921", "R-DME-70921", "R-SPO-70921", "R-SCE-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-GGA-70921:r:Histidine catabolism", "R-DME-70921:r:Histidine catabolism", "R-SPO-70921:r:Histidine catabolism", "R-SCE-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Family"}, "IPR012902": {"description": "Prokaryotic N-terminal methylation site", "go_ids": [], "go_terms": [], "name": "N_methyl_site", "pathway_ids": [], "pathways": [], "type": "PTM"}, "IPR012903": {"description": "Nif11 domain", "go_ids": [], "go_terms": [], "name": "Nif11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012904": {"description": "8-oxoguanine DNA glycosylase, N-terminal", "go_ids": ["GO:0003684", "GO:0006289", "GO:0008534"], "go_terms": ["GO:0003684:damaged DNA binding:F", "GO:0006289:nucleotide-excision repair:P", "GO:0008534:oxidized purine nucleobase lesion DNA N-glycosylase activity:F"], "name": "OGG_N", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9656255", "R-SCE-110330", "R-HSA-110357", "R-MMU-5649702", "R-MMU-110330", "R-DME-110329", "R-RNO-110331", "R-HSA-110328", "R-HSA-9656256", "R-RNO-110357", "R-SCE-110329", "R-HSA-5649702", "R-DME-110357", "R-MMU-110331", "R-DME-110331", "R-HSA-110331", "R-RNO-5649702", "R-HSA-9657050", "R-MMU-110329", "R-HSA-110329", "R-RNO-110330", "R-SCE-110331", "R-HSA-110330", "R-DME-110330", "R-MMU-110357", "R-RNO-110329"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9656255:r:Defective OGG1 Substrate Binding", "R-SCE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-DME-110329:r:Cleavage of the damaged pyrimidine", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9656256:r:Defective OGG1 Substrate Processing", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-SCE-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DME-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110331:r:Cleavage of the damaged purine", "R-DME-110331:r:Cleavage of the damaged purine", "R-HSA-110331:r:Cleavage of the damaged purine", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-9657050:r:Defective OGG1 Localization", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-SCE-110331:r:Cleavage of the damaged purine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-DME-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-RNO-110329:r:Cleavage of the damaged pyrimidine"], "type": "Domain"}, "IPR012905": {"description": "PA-IL-like", "go_ids": [], "go_terms": [], "name": "PA-IL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012906": {"description": "Transcriptional repressor PaaX-like, N-terminal", "go_ids": [], "go_terms": [], "name": "PaaX-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012907": {"description": "Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal", "go_ids": ["GO:0006508", "GO:0009002"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0009002:serine-type D-Ala-D-Ala carboxypeptidase activity:F"], "name": "Peptidase_S11_C", "pathway_ids": ["PWY-6471", "PWY-5265"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)"], "type": "Domain"}, "IPR012908": {"description": "GPI inositol-deacylase PGAP1-like alpha/beta domain", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "PGAP1-ab_dom-like", "pathway_ids": ["R-MMU-162791", "R-HSA-162791", "R-RNO-162791"], "pathways": ["R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-HSA-162791:r:Attachment of GPI anchor to uPAR", "R-RNO-162791:r:Attachment of GPI anchor to uPAR"], "type": "Domain"}, "IPR012909": {"description": "PHA accumulation regulator DNA-binding, N-terminal", "go_ids": [], "go_terms": [], "name": "PHA_DNA-bd_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012910": {"description": "TonB-dependent receptor, plug domain", "go_ids": [], "go_terms": [], "name": "Plug_dom", "pathway_ids": ["R-HSA-9638334", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR012911": {"description": "Protein serine/threonine phosphatase 2C, C-terminal", "go_ids": ["GO:0000287", "GO:0004721", "GO:0030145"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0004721:phosphoprotein phosphatase activity:F", "GO:0030145:manganese ion binding:F"], "name": "PP2C_C", "pathway_ids": ["R-MMU-2173795", "R-RNO-2173795", "R-HSA-9700645", "R-MMU-380972", "R-RNO-380972", "R-HSA-2173795", "R-RNO-1169408", "R-BTA-2173795", "R-BTA-1169408", "R-HSA-1169408", "R-MMU-1169408", "R-HSA-9725370", "R-HSA-380972", "R-BTA-380972"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK"], "type": "Domain"}, "IPR012912": {"description": "Plasmid pRiA4b, Orf3-like domain", "go_ids": [], "go_terms": [], "name": "Plasmid_pRiA4b_Orf3-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012913": {"description": "Protein OS9-like domain", "go_ids": [], "go_terms": [], "name": "OS9-like_dom", "pathway_ids": ["R-MMU-382556", "R-HSA-9931269", "R-HSA-901032", "R-HSA-382556", "R-HSA-5678895", "R-RNO-382556", "R-RNO-9931269", "R-XTR-5358346", "R-XTR-9931269", "R-MMU-5358346", "R-MMU-9931269", "R-HSA-5362768", "R-XTR-382556", "R-RNO-5358346", "R-HSA-5358346"], "pathways": ["R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-XTR-5358346:r:Hedgehog ligand biogenesis", "R-XTR-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-XTR-382556:r:ABC-family proteins mediated transport", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Domain"}, "IPR012914": {"description": "Purine catabolism PurC-like domain", "go_ids": [], "go_terms": [], "name": "PucR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012915": {"description": "Reovirus RNA-dependent RNA polymerase lambda 3", "go_ids": ["GO:0003723", "GO:0003968", "GO:0019013", "GO:0032774"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0019013:viral nucleocapsid:C", "GO:0032774:RNA biosynthetic process:P"], "name": "RdRP_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012916": {"description": "RED-like, N-terminal", "go_ids": [], "go_terms": [], "name": "RED_N", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-CEL-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR012917": {"description": "Protein of unknown function DUF3294", "go_ids": [], "go_terms": [], "name": "DUF3294", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012918": {"description": "RTP801-like", "go_ids": ["GO:0005737", "GO:0009968"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0009968:negative regulation of signal transduction:P"], "name": "RTP801-like", "pathway_ids": ["R-RNO-5628897", "R-HSA-5628897", "R-DME-5628897", "R-XTR-5628897", "R-BTA-5628897", "R-DRE-5628897", "R-MMU-5628897"], "pathways": ["R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Family"}, "IPR012919": {"description": "SUN domain", "go_ids": [], "go_terms": [], "name": "SUN_dom", "pathway_ids": ["R-HSA-9918487", "R-HSA-983168", "R-HSA-1221632"], "pathways": ["R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1221632:r:Meiotic synapsis"], "type": "Domain"}, "IPR012920": {"description": "Ribosomal RNA methyltransferase, SPB1-like, C-terminal", "go_ids": ["GO:0005634", "GO:0006364", "GO:0008168"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006364:rRNA processing:P", "GO:0008168:methyltransferase activity:F"], "name": "rRNA_MeTfrase_SPB1-like_C", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012921": {"description": "Spen paralogue and orthologue SPOC, C-terminal", "go_ids": [], "go_terms": [], "name": "SPOC_C", "pathway_ids": ["R-SCE-6782135", "R-MMU-9013422", "R-HSA-9013422", "R-HSA-9845323", "R-SPO-6782210", "R-SPO-6796648", "R-SPO-6782135", "R-HSA-1221632", "R-SCE-6782210", "R-SCE-6796648"], "pathways": ["R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-1221632:r:Meiotic synapsis", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes"], "type": "Domain"}, "IPR012922": {"description": "ORF D-335-like", "go_ids": [], "go_terms": [], "name": "ORF_D-335", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012923": {"description": "Chromosome segregation in meiosis protein 3", "go_ids": ["GO:0005634", "GO:0006974", "GO:0031297"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006974:DNA damage response:P", "GO:0031297:replication fork processing:P"], "name": "Csm3", "pathway_ids": ["R-HSA-5693607", "R-MMU-5693607", "R-GGA-5693607"], "pathways": ["R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-GGA-5693607:r:Processing of DNA double-strand break ends"], "type": "Domain"}, "IPR012924": {"description": "TfuA-like, core", "go_ids": [], "go_terms": [], "name": "TfuA_core", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012925": {"description": "TipAS antibiotic-recognition domain", "go_ids": [], "go_terms": [], "name": "TipAS_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012926": {"description": "TMEM120A/B", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TMEM120A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012927": {"description": "Effector protease OspD3-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Toxin_15_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012928": {"description": "Clostridium neurotoxin, receptor binding N-terminal", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Toxin_rcpt-bd_N", "pathway_ids": ["R-HSA-5250989", "R-HSA-5250968", "R-HSA-5250971", "R-HSA-5250982", "R-HSA-5250992", "R-HSA-5250955", "R-HSA-5250981", "R-HSA-5250958"], "pathways": ["R-HSA-5250989:r:Toxicity of botulinum toxin type G (botG)", "R-HSA-5250968:r:Toxicity of botulinum toxin type A (botA)", "R-HSA-5250971:r:Toxicity of botulinum toxin type C (botC)", "R-HSA-5250982:r:Toxicity of tetanus toxin (tetX)", "R-HSA-5250992:r:Toxicity of botulinum toxin type E (botE)", "R-HSA-5250955:r:Toxicity of botulinum toxin type D (botD)", "R-HSA-5250981:r:Toxicity of botulinum toxin type F (botF)", "R-HSA-5250958:r:Toxicity of botulinum toxin type B (botB)"], "type": "Domain"}, "IPR012929": {"description": "Nucleoprotein, TPR/MLP1-2 domain", "go_ids": ["GO:0006606"], "go_terms": ["GO:0006606:protein import into nucleus:P"], "name": "Nucleoprot-TPR/MLP1-2_dom", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-RNO-3301854", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-159230", "R-HSA-159227", "R-HSA-159230", "R-MMU-4085377", "R-RNO-159230", "R-MMU-4551638", "R-HSA-168333", "R-RNO-191859", "R-HSA-3371453", 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DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-159230:r:Transport of the 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response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Domain"}, "IPR012930": {"description": "TraC-like", "go_ids": [], "go_terms": [], "name": "TraC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012931": {"description": "TraG, N-terminal, Proteobacteria", "go_ids": [], "go_terms": [], "name": "TraG_N_Proteobacteria", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012932": {"description": "Vitamin K epoxide reductase", "go_ids": [], "go_terms": [], "name": "VKOR", "pathway_ids": ["PWY-7999", "R-MMU-6806664", "R-BTA-6806664", "R-HSA-6806664", "R-RNO-6806664"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "R-MMU-6806664:r:Metabolism of vitamin K", "R-BTA-6806664:r:Metabolism of vitamin K", "R-HSA-6806664:r:Metabolism of vitamin K", "R-RNO-6806664:r:Metabolism of vitamin K"], "type": "Domain"}, "IPR012933": {"description": "HicA mRNA interferase family", "go_ids": ["GO:0003729"], "go_terms": ["GO:0003729:mRNA binding:F"], "name": "HicA_mRNA_interferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012934": {"description": "Zinc finger, AD-type", "go_ids": ["GO:0005634", "GO:0008270"], "go_terms": ["GO:0005634:nucleus:C", "GO:0008270:zinc ion binding:F"], "name": "Znf_AD", "pathway_ids": ["R-DME-214842", "R-DME-214874", "R-DME-214844", "R-DME-214863", "R-DME-214869", "R-DME-214862"], "pathways": ["R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"], "type": "Domain"}, "IPR012935": {"description": "NuBaID, N-terminal domain", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc 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"Glyco_hydro_92", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012940": {"description": "Nucleic acid binding NABP", "go_ids": [], "go_terms": [], "name": "NABP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012941": {"description": "Phenol hydroxylase-like, C-terminal dimerisation domain", "go_ids": [], "go_terms": [], "name": "Phe_hydrox_C_dim_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012942": {"description": "SRR1-like domain", "go_ids": [], "go_terms": [], "name": "SRR1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012943": {"description": "Centrosomin, N-terminal motif 1", "go_ids": ["GO:0005815"], "go_terms": ["GO:0005815:microtubule organizing center:C"], "name": "Cnn_1N", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-MMU-380270", "R-HSA-380284", "R-HSA-380270", "R-RNO-5620912", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-RNO-380320", "R-RNO-380259", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR012944": {"description": "RagB/SusD domain", "go_ids": [], "go_terms": [], "name": "SusD_RagB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012945": {"description": "Tubulin binding cofactor C-like domain", "go_ids": [], "go_terms": [], "name": "Tubulin-bd_cofactor_C_dom", "pathway_ids": ["R-MMU-5624138", "R-HSA-5624138", "R-DRE-5624138", "R-HSA-389977"], "pathways": ["R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway"], "type": "Domain"}, "IPR012946": {"description": "X8 domain", "go_ids": [], "go_terms": [], "name": "X8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012947": {"description": "Threonyl/alanyl tRNA synthetase, SAD", "go_ids": ["GO:0005524", "GO:0004812", "GO:0043039"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0004812:aminoacyl-tRNA ligase activity:F", "GO:0043039:tRNA aminoacylation:P"], "name": "tRNA_SAD", "pathway_ids": ["R-HSA-379716", "R-HSA-379726"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Domain"}, "IPR012948": {"description": "AARP2CN", "go_ids": ["GO:0005634", "GO:0042254"], "go_terms": ["GO:0005634:nucleus:C", "GO:0042254:ribosome 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"GO:0050660:flavin adenine dinucleotide binding:F"], "name": "BBE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012952": {"description": "BING4, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BING4_C_dom", "pathway_ids": ["R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-CFA-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-SPO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012953": {"description": "BOP1, N-terminal domain", "go_ids": ["GO:0006364"], "go_terms": ["GO:0006364:rRNA processing:P"], "name": "BOP1_N_dom", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DRE-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012954": {"description": "BP28, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BP28_C_dom", "pathway_ids": ["R-DME-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012955": {"description": "CASP, C-terminal", "go_ids": ["GO:0006891", "GO:0000139"], "go_terms": ["GO:0006891:intra-Golgi vesicle-mediated transport:P", "GO:0000139:Golgi membrane:C"], "name": "CASP_C", "pathway_ids": ["R-HSA-6811438"], "pathways": ["R-HSA-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR012956": {"description": "CARG-binding factor, N-terminal", "go_ids": [], "go_terms": [], "name": "CARG-binding_factor_N", "pathway_ids": ["R-MMU-450408", "R-HSA-72163", "R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-RNO-72203", "R-MMU-9770562", "R-MMU-72163", "R-RNO-9770562", "R-HSA-9918487", "R-RNO-72163", "R-HSA-450408", "R-HSA-9918481", "R-RNO-450408"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA"], "type": "Domain"}, "IPR012957": {"description": "CHD, C-terminal 2", "go_ids": [], "go_terms": [], "name": "CHD_C2", "pathway_ids": ["PWY-7250", "R-MMU-73762", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-MMU-9031628", "R-MMU-8943724", "R-DME-3214815", "R-HSA-6804758", "R-CEL-8943724", "R-HSA-9844594", "R-HSA-9845323", "R-HSA-8943724", "R-CEL-4551638", "R-MMU-6804758", "R-DME-6804758", "R-HSA-9843940", "R-DME-9031628", "R-HSA-427389", "R-HSA-9031628", "R-CEL-9031628", "R-HSA-4551638", "R-DME-8943724"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-9031628:r:NGF-stimulated transcription", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-9031628:r:NGF-stimulated transcription", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-8943724:r:Regulation of PTEN gene transcription"], "type": "Domain"}, "IPR012958": {"description": "CHD, N-terminal", "go_ids": [], "go_terms": [], "name": "CHD_N", "pathway_ids": ["PWY-7250", "R-MMU-73762", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-MMU-9031628", "R-MMU-8943724", "R-DME-3214815", "R-HSA-6804758", "R-CEL-8943724", "R-HSA-9844594", "R-HSA-9845323", "R-HSA-8943724", "R-CEL-4551638", "R-MMU-6804758", "R-DME-6804758", "R-HSA-9843940", "R-DME-9031628", "R-HSA-427389", "R-HSA-9031628", "R-CEL-9031628", "R-HSA-4551638", "R-DME-8943724"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-9031628:r:NGF-stimulated transcription", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-9031628:r:NGF-stimulated transcription", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-8943724:r:Regulation of PTEN gene transcription"], "type": "Domain"}, "IPR012959": {"description": "CPL domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "CPL_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012960": {"description": "Dyskerin-like", "go_ids": [], "go_terms": [], "name": "Dyskerin-like", "pathway_ids": ["R-CEL-171319", "R-SPO-171319", "R-GGA-417076", "R-DME-171319", "R-SCE-171319", "R-DRE-171319", "R-RNO-171319", "R-DDI-171319", "R-HSA-6790901", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-CEL-171319:r:Telomere Extension By Telomerase", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-GGA-417076:r:Assembly of telomerase and telomere extension", "R-DME-171319:r:Telomere Extension By Telomerase", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DDI-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR012961": {"description": "ATP-dependent RNA helicase Ski2/MTR4, C-terminal", "go_ids": [], "go_terms": [], "name": "Ski2/MTR4_C", "pathway_ids": ["R-MMU-9930044", "R-MMU-6791226", "R-HSA-9930044", "R-HSA-390471", "R-MMU-72163", "R-MMU-429958", "R-SPO-9930044", "R-HSA-72163", "R-SCE-429958", "R-SCE-6791226", "R-HSA-6791226", "R-HSA-9843970", "R-CEL-9930044", "R-CEL-6791226", "R-HSA-429958", "R-CEL-72163", "R-SPO-429958", "R-SPO-72163", "R-SPO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012962": {"description": "Peptidase M54, archaemetzincin", "go_ids": ["GO:0006508", "GO:0008233"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008233:peptidase activity:F"], "name": "Pept_M54_archaemetzincn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012963": {"description": "HAAS transmembrane region", "go_ids": [], "go_terms": [], "name": "HAAS_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012964": {"description": "Protein of unknown function DUF1702", "go_ids": [], "go_terms": [], "name": "DUF1702", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012965": {"description": "Meiotically up-regulated protein Msb1/Mug8 domain", "go_ids": [], "go_terms": [], "name": "Msb1/Mug8_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012966": {"description": "Anillin homology domain", "go_ids": [], "go_terms": [], "name": "AHD", "pathway_ids": ["R-RNO-9013026", "R-RNO-5666185", "R-HSA-8980692", "R-CEL-8980692", "R-DME-8980692", "R-MMU-9013106", "R-MMU-9013026", "R-MMU-8980692", "R-HSA-5666185", "R-RNO-8980692", "R-HSA-9013026", "R-RNO-9013106", "R-HSA-9013106", "R-MMU-5666185"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CEL-8980692:r:RHOA GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins"], "type": "Domain"}, "IPR012967": {"description": "Caffeic acid 3-O-methyltransferase-like, dimerisation domain", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "COMT-like_dimerisation", "pathway_ids": ["R-DDI-209931", "R-HSA-209931", "R-RNO-209931", "R-MMU-209931", "R-BTA-209931"], "pathways": ["R-DDI-209931:r:Serotonin and melatonin biosynthesis", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-209931:r:Serotonin and melatonin biosynthesis", "R-BTA-209931:r:Serotonin and melatonin biosynthesis"], "type": "Domain"}, "IPR012968": {"description": "FerIin domain", "go_ids": [], "go_terms": [], "name": "FerIin_dom", "pathway_ids": ["R-HSA-9662360", "R-HSA-9609523", "R-HSA-445355"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-445355:r:Smooth Muscle Contraction"], "type": "Domain"}, "IPR012969": {"description": "Fibrinogen binding protein", "go_ids": [], "go_terms": [], "name": "Fibrinogen_BP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012970": {"description": "Polysaccharide lyase 8, N-terminal alpha-helical", "go_ids": [], "go_terms": [], "name": "Lyase_8_alpha_N", "pathway_ids": ["PWY-7645"], "pathways": ["PWY-7645:t:hyaluronan degradation"], "type": "Domain"}, "IPR012971": {"description": "Nucleolar GTP-binding protein 2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NOG2_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012972": {"description": "NLE", "go_ids": [], "go_terms": [], "name": "NLE", "pathway_ids": ["R-MMU-6791226", "R-DME-983168", "R-XTR-6791226", "R-BTA-6791226", "R-DDI-6791226", "R-DME-8951664", "R-DME-6791226", "R-CEL-983168", "R-DDI-8951664", "R-RNO-6791226", "R-DDI-983168", "R-SCE-6791226", "R-HSA-6791226", "R-DRE-6791226", "R-SPO-983168", "R-SPO-8951664", "R-CEL-6791226", "R-SCE-983168", "R-SPO-6791226", "R-CEL-8951664"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-8951664:r:Neddylation", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-8951664:r:Neddylation", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-8951664:r:Neddylation", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR012973": {"description": "NOG, C-terminal", "go_ids": [], "go_terms": [], "name": "NOG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012974": {"description": "Nucleolar protein 58/56, N-terminal", "go_ids": [], "go_terms": [], "name": "NOP58/56_N", "pathway_ids": ["R-MMU-6791226", "R-SPO-4570464", "R-SCE-4570464", "R-SCE-6791226", "R-HSA-390471", "R-HSA-6791226", "R-RNO-4570464", "R-DDI-6791226", "R-DDI-4570464", "R-MMU-4570464", "R-HSA-4570464", "R-CEL-6791226", "R-SPO-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-SCE-4570464:r:SUMOylation of RNA binding proteins", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012975": {"description": "NOPS", "go_ids": [], "go_terms": [], "name": "NOPS", "pathway_ids": ["R-HSA-8849468", "R-MMU-8849468", "R-HSA-9635465"], "pathways": ["R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-9635465:r:Suppression of apoptosis"], "type": "Domain"}, "IPR012976": {"description": "NOSIC", "go_ids": [], "go_terms": [], "name": "NOSIC", "pathway_ids": ["R-MMU-6791226", "R-SCE-4570464", "R-HSA-390471", "R-MMU-72163", "R-DDI-6791226", "R-DDI-4570464", "R-MMU-4570464", "R-HSA-6790901", "R-RNO-6791226", "R-HSA-72163", "R-SPO-4570464", "R-SCE-6791226", "R-HSA-6791226", "R-RNO-4570464", "R-HSA-4570464", "R-CEL-6791226", "R-SPO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012977": {"description": "SDA1, N-terminal", "go_ids": [], "go_terms": [], "name": "SDA1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012978": {"description": "RRP12, HEAT domain", "go_ids": [], "go_terms": [], "name": "HEAT_RRP12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012980": {"description": "PELP1, middle domain", "go_ids": [], "go_terms": [], "name": "PELP1_middle", "pathway_ids": ["R-HSA-6791226", "R-MMU-6791226", "R-HSA-8849473", "R-RNO-6791226"], "pathways": ["R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-8849473:r:PTK6 Expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR012981": {"description": "PIH1, N-terminal", "go_ids": [], "go_terms": [], "name": "PIH1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR012982": {"description": "PARP1-like, PADR1 domain, zinc ribbon fold", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "PARP1-like_PADR1_Zn_ribbon", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-MMU-2173795", "R-HSA-3108214", "R-HSA-192814", "R-RNO-5696395", "R-HSA-110362", "R-DRE-5696400", "R-RNO-5685939", "R-DME-5696395", "R-RNO-110362", "R-RNO-3108214", "R-DRE-5685939", "R-HSA-5685939", "R-DRE-5696394", "R-DME-5696394", "R-DRE-110362", "R-RNO-5696394", "R-DRE-5696395", "R-DRE-3108214", "R-MMU-5696395", "R-RNO-2173795", "R-MMU-110362", "R-DME-5696400", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-2173795", "R-HSA-5696394", "R-RNO-5696400", "R-MMU-5685939", "R-HSA-5696400", "R-MMU-5696394", "R-MMU-3108214", "R-CEL-5696394", "R-MMU-5696400"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-192814:r:vRNA Synthesis", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696400:r:Dual Incision in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER"], "type": "Domain"}, "IPR012983": {"description": "PHR", "go_ids": [], "go_terms": [], "name": "PHR", "pathway_ids": ["R-MMU-8951664", "R-DRE-8951664", "R-HSA-983168", "R-MMU-983168", "R-HSA-8951664", "R-DRE-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8951664:r:Neddylation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR012984": {"description": "PROCT domain", "go_ids": [], "go_terms": [], "name": "PROCT", "pathway_ids": ["R-HSA-72163", "R-CEL-72165", "R-MMU-72165", "R-MMU-72163", "R-HSA-72165", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR012985": {"description": "Peptidase S64, Ssy5", "go_ids": [], "go_terms": [], "name": "Peptidase_S64_Ssy5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012986": {"description": "Photosystem I PsaX", "go_ids": [], "go_terms": [], "name": "PSI_PsaX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012987": {"description": "ROK, N-terminal", "go_ids": [], "go_terms": [], "name": "ROK_N", "pathway_ids": ["R-HSA-9610379", "R-HSA-72163", "R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-RNO-72203", "R-MMU-9770562", "R-MMU-72163", "R-RNO-4570464", "R-RNO-9770562", "R-HSA-4570464", "R-MMU-4570464", "R-BTA-9770562", "R-BTA-4570464", "R-RNO-72163", "R-BTA-72203", "R-HSA-9918481", "R-BTA-72163"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR012988": {"description": "Large ribosomal subunit protein uL30, N-terminal, eukaryota", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL30_N_euk", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-GGA-72706", "R-CEL-9954716", "R-CEL-9954714", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-MMU-6791226", "R-HSA-1799339", "R-HSA-2408557", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-GGA-9954716", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-GGA-975956", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-RNO-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-GGA-9954714", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-GGA-9954709", "R-BTA-9954714", "R-GGA-975957", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-GGA-1799339", "R-DME-975957", "R-DDI-156827", "R-DDI-9954716", "R-RNO-9954714", "R-HSA-9633012"], "pathways": 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independent of the Exon Junction Complex (EJC)", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR012989": {"description": "SEP domain", "go_ids": [], "go_terms": [], "name": "SEP_domain", "pathway_ids": ["R-CEL-9013407", "R-BTA-9013407", "R-GGA-9013407", "R-MMU-9013407", "R-HSA-9013407", "R-HSA-9696270", "R-RNO-9696270", "R-RNO-9013407", "R-RNO-9696264", "R-MMU-9696270", "R-MMU-9696264", "R-RNO-9696273", "R-MMU-9696273", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-CEL-9013407:r:RHOH GTPase cycle", "R-BTA-9013407:r:RHOH GTPase cycle", "R-GGA-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR012990": {"description": "Sec23/Sec24, beta-sandwich", "go_ids": [], "go_terms": [], "name": "Beta-sandwich_Sec23_24", "pathway_ids": ["R-HSA-1655829", "R-MMU-204005", "R-DDI-983170", "R-HSA-2132295", "R-XTR-204005", "R-DDI-204005", "R-HSA-9705671", "R-DDI-5694530", "R-MMU-5694530", "R-DRE-204005", "R-SCE-204005", "R-SPO-204005", "R-XTR-5694530", "R-SPO-5694530", "R-DRE-5694530", "R-DRE-983170", "R-HSA-5694530", "R-BTA-983170", "R-HSA-204005", "R-HSA-983170", "R-DRE-2132295", "R-SCE-5694530", "R-BTA-5694530", "R-MMU-2132295", "R-MMU-983170", "R-BTA-204005", "R-BTA-2132295", "R-SPO-983170", "R-SCE-983170"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-2132295:r:MHC class II antigen presentation", "R-XTR-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-5694530:r:Cargo concentration in the ER", "R-MMU-5694530:r:Cargo concentration in the ER", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-XTR-5694530:r:Cargo concentration in the ER", "R-SPO-5694530:r:Cargo concentration in the ER", "R-DRE-5694530:r:Cargo concentration in the ER", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-2132295:r:MHC class II antigen presentation", "R-SCE-5694530:r:Cargo concentration in the ER", "R-BTA-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "type": "Domain"}, "IPR012992": {"description": "Tetracycline resistance leader peptide, TetM", "go_ids": [], "go_terms": [], "name": "Tet-R_leader_TetM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012993": {"description": "UME domain", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "UME", "pathway_ids": ["R-HSA-5693616", "R-DDI-6803207", "R-DDI-6804760", "R-SCE-2559586", "R-DDI-2559586", "R-MMU-6804756", "R-HSA-1221632", "R-HSA-6796648", "R-SPO-9664873", "R-SPO-6804756", "R-MMU-5685938", "R-DDI-5693565", "R-MMU-69473", "R-SCE-5693565", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-SCE-9664873", "R-DDI-6804756", "R-SCE-5693548", "R-DDI-5693607", "R-SPO-6803207", "R-HSA-176187", "R-HSA-5685938", "R-MMU-5693607", "R-DME-176187", "R-DDI-5693616", "R-HSA-69473", "R-DME-69473", "R-SPO-5693565", "R-HSA-6783310", "R-MMU-6783310", "R-HSA-6804756", "R-DDI-349425", "R-SPO-2559586", "R-DDI-9664873", "R-MMU-176187", "R-SPO-5693548", "R-DDI-5693548"], "pathways": ["R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DDI-6804760:r:Regulation of TP53 Activity through Methylation", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-9664873:r:Pexophagy", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-9664873:r:Pexophagy", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DME-69473:r:G2/M DNA damage checkpoint", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-9664873:r:Pexophagy", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-DDI-5693548:r:Sensing of DNA Double Strand Breaks"], "type": "Domain"}, "IPR012994": {"description": "Membrane bound YbgT-like", "go_ids": [], "go_terms": [], "name": "YbgT_YccB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR012996": {"description": "Zinc finger, CHHC-type", "go_ids": [], "go_terms": [], "name": "Znf_CHHC", "pathway_ids": ["R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-RNO-72203", "R-MMU-9770562", "R-MMU-72163", "R-HSA-6803529", "R-HSA-8950505", "R-RNO-72163", "R-HSA-72163", "R-RNO-9770562", "R-BTA-9770562", "R-BTA-72203", "R-HSA-9918481", "R-RNO-6803529", "R-BTA-72163"], "pathways": ["R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR012997": {"description": "Rare lipoprotein A", "go_ids": [], "go_terms": [], "name": "RplA", "pathway_ids": ["PWY-7246", "PWY-7647"], "pathways": ["PWY-7246:t:pectin degradation I", "PWY-7647:t:ulvan degradation"], "type": "Domain"}, "IPR013005": {"description": "Large ribosomal subunit protein uL4-like", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL4-like", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-DRE-5389840", "R-BTA-9937383", "R-DRE-5419276"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR013012": {"description": "Phosphotransferase system, EIIB component, type 3", "go_ids": ["GO:0008982", "GO:0009401"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PTS_EIIB_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013015": {"description": "Laminin IV type B", "go_ids": [], "go_terms": [], "name": "Laminin_IV_B", "pathway_ids": ["R-HSA-1474228", "R-HSA-9925563", "R-HSA-8874081", "R-HSA-3000157", "R-HSA-3000178", "R-HSA-9913351", "R-HSA-3000171", "R-HSA-9619665", "R-HSA-373760", "R-HSA-9638630", "R-HSA-8957275", "R-HSA-381426", "R-DME-373752"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-3000157:r:Laminin interactions", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-373752:r:Netrin-1 signaling"], "type": "Domain"}, "IPR013016": {"description": "Peptidase C16, coronavirus", "go_ids": ["GO:0006508", "GO:0008234"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008234:cysteine-type peptidase activity:F"], "name": "Peptidase_C16_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR013020": {"description": "ATP-dependent helicase Rad3/Chl1-like", "go_ids": ["GO:0003678"], "go_terms": ["GO:0003678:DNA helicase activity:F"], "name": "Rad3/Chl1-like", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-MMU-113418", "R-HSA-5693616", "R-HSA-5693579", "R-HSA-427413", "R-BTA-76042", "R-GGA-5693616", "R-DDI-73776", "R-MMU-6804756", "R-DDI-6782210", "R-SPO-6781823", "R-MMU-5693616", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-5685938", "R-MMU-112382", "R-HSA-6781823", "R-MMU-69473", "R-MMU-5696395", "R-HSA-167246", "R-SPO-5696395", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-HSA-9709570", "R-DDI-674695", "R-HSA-5693607", "R-HSA-75953", "R-HSA-77075", "R-MMU-5693568", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-BTA-73863", "R-BTA-75955", "R-SPO-113418", "R-BTA-75953", "R-DDI-73779", "R-BTA-72086", "R-HSA-69473", "R-BTA-6782135", "R-DDI-6781823", "R-DDI-72086", "R-DRE-171319", "R-MMU-674695", "R-SCE-76042", "R-MMU-171319", "R-HSA-167161", "R-HSA-167200", "R-HSA-6804756", "R-HSA-9704331", "R-SCE-674695", "R-HSA-167160", "R-HSA-5696395", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-MMU-73772", "R-MMU-6782210", "R-MMU-72086", "R-GGA-5693607", "R-BTA-73772", "R-BTA-73776", "R-SPO-73776", "R-DDI-113418", "R-HSA-5693554", "R-SCE-6782135", "R-SCE-73776", "R-DDI-6782135", "R-GGA-351465", "R-MMU-73762", "R-GGA-5685938", "R-DDI-5696395", "R-HSA-6781827", "R-HSA-5685942", "R-MMU-6782135", "R-GGA-5685942", "R-BTA-113418", "R-HSA-9704646", "R-HSA-72086", "R-RNO-171319", "R-HSA-171319", "R-HSA-167162", "R-BTA-6781823", "R-MMU-6781823", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696395", "R-MMU-5693579", "R-BTA-5696400", "R-SCE-6782210", "R-HSA-167172", "R-BTA-6796648", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5696400", "R-BTA-73779", "R-SCE-6796648", "R-MMU-5693607", "R-HSA-9701192", "R-BTA-73762", "R-SCE-73779", "R-HSA-2564830", "R-SPO-77075", "R-HSA-381038", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-GGA-5693568", "R-MMU-73863", "R-SCE-6781823", "R-HSA-6782135", "R-BTA-674695", "R-HSA-73762", "R-MMU-5685942", "R-HSA-9709603", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-SPO-5696400", "R-SCE-77075", "R-HSA-75955", "R-SPO-6782210", "R-HSA-5696400", "R-HSA-674695", "R-HSA-76042", "R-SPO-6782135", "R-SCE-73772", "R-DDI-75953", "R-GGA-5693579", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782135:r:Dual incision in TC-NER", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-72086:r:mRNA Capping", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-GGA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-GGA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR013021": {"description": "Myo-inositol-1-phosphate synthase, GAPDH-like", "go_ids": [], "go_terms": [], "name": "Myo-inos-1-P_Synthase_GAPDH", "pathway_ids": ["PWY-6580", "PWY-2301", "PWY-6372", "PWY-4661", "PWY-6664", "R-DME-1855183", "R-DDI-1855183", "R-HSA-1855183", "R-BTA-1855183", "R-MMU-1855183", "R-PFA-1855183", "R-MTU-879299", "R-SCE-1855183", "R-RNO-1855183"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-2301:t:myo-inositol biosynthesis", "PWY-6372:t:1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)", "PWY-4661:t:1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)", "PWY-6664:t:di-myo-inositol phosphate 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"name": "KARI", "pathway_ids": ["PWY-7111", "PWY-5103"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-5103:t:L-isoleucine biosynthesis III"], "type": "Family"}, "IPR013025": {"description": "Large ribosomal subunit protein uL23-like", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uL23-like", "pathway_ids": ["R-DRE-5419276", "R-SCE-156827", "R-CEL-9954709", "R-CEL-5389840", "R-MMU-975957", "R-HSA-156902", "R-HSA-9937383", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-DRE-5389840", "R-MMU-156827", "R-HSA-975957", "R-MMU-5419276", "R-DME-5419276", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-CEL-5419276", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012", "R-HSA-5419276", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9937383", 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"R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "type": "Family"}, "IPR013029": {"description": "YchF, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YchF_C", "pathway_ids": ["R-HSA-114608", "R-BTA-114608", "R-DRE-114608", "R-DME-114608", "R-CEL-114608", "R-SCE-114608", "R-GGA-114608", "R-SPO-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-DME-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-SCE-114608:r:Platelet degranulation", "R-GGA-114608:r:Platelet degranulation", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR013030": {"description": "DNA topoisomerase I, DNA binding, N-terminal domain 2", "go_ids": ["GO:0003677", "GO:0003917", "GO:0005694", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003917:DNA topoisomerase type I (single strand cut, ATP-independent) activity:F", "GO:0005694:chromosome:C", "GO:0006265:DNA topological change:P"], "name": "DNA_topo_DNA_db_N_dom2", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-HSA-4615885", "R-SPO-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Homologous_superfamily"}, "IPR013032": {"description": "EGF-like, conserved site", "go_ids": [], "go_terms": [], "name": "EGF-like_CS", "pathway_ids": ["R-BTA-216083", "R-DME-9604323", "R-XTR-2979096", "R-HSA-159782", "R-HSA-9604323", "R-HSA-140837", "R-HSA-9010553", "R-HSA-9918485", "R-MMU-2122948", "R-RNO-9013149", "R-DME-1912420", "R-CEL-1566948", "R-HSA-9818749", "R-BTA-2173789", "R-MMU-8957275", "R-BTA-8957275", "R-RNO-350054", "R-MMU-1912420", "R-HSA-5083630", "R-CEL-2129379", "R-HSA-2979096", "R-HSA-9818030", "R-MMU-381426", "R-CEL-381426", "R-HSA-9926550", "R-CEL-8957275", "R-RNO-1912420", "R-HSA-2691232", "R-HSA-9013507", "R-MMU-1566948", "R-HSA-2122947", "R-DME-2979096", "R-MMU-9013700", "R-HSA-2173789", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-CEL-216083", "R-DME-9013149", "R-BTA-1566948", "R-CEL-2979096", "R-DRE-2979096", "R-BTA-1474228", "R-XTR-9013507", "R-RNO-9013507", "R-HSA-373752", "R-HSA-9017802", "R-RNO-8964011", "R-MMU-9604323", "R-MMU-9013423", "R-HSA-159740", "R-HSA-9013149", "R-RNO-196791", "R-HSA-9013695", "R-MMU-376176", "R-HSA-2644607", "R-HSA-2660826", "R-MMU-350054", "R-MMU-9913351", "R-MMU-216083", "R-HSA-9793380", "R-DME-9013700", "R-HSA-2644606", "R-CEL-2173789", "R-DME-9010553", "R-XTR-9017802", "R-MMU-446107", "R-DRE-9013423", "R-HSA-201681", "R-DME-381426", "R-HSA-8941856", "R-DME-8957275", "R-HSA-2122948", "R-RNO-9017802", "R-MMU-2122947", "R-XTR-8941856", "R-MMU-9010553", "R-HSA-1566948", "R-XTR-2122948", "R-HSA-9824272", "R-RNO-2129379", "R-XTR-2197563", "R-XTR-1912420", "R-HSA-1912408", "R-HSA-114608", "R-CEL-9010553", "R-HSA-9013423", "R-CEL-1474228", "R-MMU-8874081", "R-RNO-9758881", "R-HSA-977606", "R-HSA-9013700", "R-MMU-9013507", "R-BTA-381426", "R-DRE-9013149", "R-DME-428890", "R-DME-9013423", "R-BTA-2129379", "R-RNO-2173789", "R-DME-376176", "R-HSA-159763", "R-HSA-1912420", "R-HSA-3772470", "R-HSA-9013508", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-216083", "R-HSA-8985801", "R-MMU-3000157", "R-HSA-210744", "R-HSA-428542", "R-HSA-376176", "R-HSA-2894862", "R-MMU-428890", "R-DME-446107", "R-MMU-8985586", "R-MMU-9017802", "R-HSA-140875", "R-HSA-350054", "R-RNO-9013423", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-MMU-8941856", "R-HSA-428540", "R-HSA-8957275", "R-HSA-9831926", "R-HSA-428890", "R-HSA-2197563", "R-MMU-9013149", "R-CEL-376176", "R-HSA-1912399", "R-HSA-202733", "R-MMU-2129379"], "pathways": ["R-BTA-216083:r:Integrin cell surface interactions", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DME-1912420:r:Pre-NOTCH Processing in Golgi", "R-CEL-1566948:r:Elastic fibre formation", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-DME-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-CEL-216083:r:Integrin cell surface interactions", "R-DME-9013149:r:RAC1 GTPase cycle", "R-BTA-1566948:r:Elastic fibre formation", "R-CEL-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DRE-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-RNO-8964011:r:HDL clearance", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-DME-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-XTR-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-1566948:r:Elastic fibre formation", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9824272:r:Somitogenesis", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-376176:r:Signaling by ROBO receptors", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-MMU-3000157:r:Laminin interactions", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-428540:r:Activation of RAC1", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9831926:r:Nephron development", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Conserved_site"}, "IPR013033": {"description": "Septum formation inhibitor MinC", "go_ids": ["GO:0051726", "GO:1901891"], "go_terms": ["GO:0051726:regulation of cell cycle:P", "GO:1901891:regulation of cell septum assembly:P"], "name": "MinC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013034": {"description": "DNA topoisomerase I, DNA binding, N-terminal domain 1", "go_ids": ["GO:0003917", "GO:0006265"], "go_terms": ["GO:0003917:DNA topoisomerase type I (single strand cut, ATP-independent) activity:F", "GO:0006265:DNA topological change:P"], "name": "DNA_topo_DNA_db_N_dom1", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-HSA-4615885", "R-SPO-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Homologous_superfamily"}, "IPR013035": {"description": "Phosphoenolpyruvate carboxykinase, C-terminal", "go_ids": ["GO:0004611", "GO:0006094", "GO:0017076"], "go_terms": ["GO:0004611:phosphoenolpyruvate carboxykinase activity:F", "GO:0006094:gluconeogenesis:P", "GO:0017076:purine nucleotide binding:F"], "name": "PEP_carboxykinase_C", "pathway_ids": ["PWY-561", "PWY-7117", "R-HSA-70263", "R-HSA-9615017", "R-HSA-381340", "R-HSA-9632974", "R-MMU-70263", "R-HSA-2161541", "R-GGA-352875", "R-DME-70263", "R-DDI-70263", "R-RNO-70263"], "pathways": ["PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "R-HSA-70263:r:Gluconeogenesis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-HSA-2161541:r:Abacavir metabolism", "R-GGA-352875:r:Gluconeogenesis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR013036": {"description": "Domain of unknown function DUF1587", "go_ids": [], "go_terms": [], "name": "DUF1587", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013037": {"description": "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain", "go_ids": ["GO:0006886", "GO:0016192"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P"], "name": "Clathrin_b-adaptin_app_Ig-like", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-HSA-2132295", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-432722", "R-HSA-9918485", "R-BTA-416993", "R-DDI-437239", "R-MMU-5099900", "R-RNO-8964038", "R-DDI-8856825", "R-DDI-8866427", "R-MMU-2132295", "R-RNO-177504", "R-MMU-8964038", "R-DDI-8856828", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-MMU-432720", "R-HSA-5140745", "R-RNO-5099900", "R-HSA-432722", "R-DDI-8964038", "R-RNO-8866427", "R-BTA-2132295", "R-RNO-432722", "R-MMU-416993", "R-BTA-8856828", "R-RNO-2132295", "R-HSA-416993", "R-MMU-437239", "R-RNO-8856825", "R-RNO-437239", "R-RNO-432720", "R-BTA-5099900", "R-HSA-432720", "R-DDI-432720", "R-HSA-167590", "R-HSA-437239", "R-HSA-5099900", "R-HSA-9679191", "R-MMU-5140745", "R-BTA-177504", "R-HSA-164940", "R-HSA-177504", "R-HSA-8866427", "R-BTA-8856825", "R-BTA-8964038", "R-HSA-8856825", "R-HSA-3928665", "R-MMU-8866427", "R-MMU-177504", "R-BTA-5140745", "R-HSA-8964038", "R-RNO-416993", "R-HSA-182218"], "pathways": ["R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-2132295:r:MHC class II antigen presentation", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DDI-437239:r:Recycling pathway of L1", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-8964038:r:LDL clearance", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-MMU-8964038:r:LDL clearance", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-BTA-2132295:r:MHC class II antigen presentation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", 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"R-HSA-9670095", "R-DME-203754", "R-HSA-3232118", "R-RNO-3232142", "R-RNO-9841922", "R-HSA-179409", "R-DRE-5693607", "R-HSA-201681", "R-HSA-8941856", "R-HSA-1059683", "R-BTA-975871", "R-HSA-201451", "R-CEL-210500", "R-HSA-3785653", "R-DRE-8953750", "R-CEL-9934037", "R-BTA-3899300", "R-HSA-3656532", "R-MMU-349425", "R-BTA-2871837", "R-HSA-114608", "R-BTA-174154", "R-MMU-9627069", "R-DDI-69601", "R-HSA-912446", "R-CFA-6804760", "R-HSA-9013148", "R-DDI-76042", "R-HSA-4615885", "R-MMU-9029569", "R-DDI-5689880", "R-MMU-5696400", "R-MMU-2173789", "R-HSA-399719", "R-MMU-3899300", "R-MMU-209560", "R-HSA-210744", "R-CEL-9755511", "R-DRE-9013424", "R-MMU-5675482", "R-SCE-6781823", "R-MMU-5656169", "R-BTA-9013422", "R-MMU-111469", "R-HSA-5357956", "R-RNO-8941856", "R-SPO-6782210", "R-DDI-203754", "R-HSA-3214847", "R-DME-6782210", "R-HSA-76042", "R-HSA-9725370", "R-SPO-8854050", "R-MMU-9856649", "R-HSA-8849469", "R-HSA-9825895", "R-MMU-5632684", "R-HSA-2151201", "R-HSA-5693616", "R-HSA-1234158", "R-MMU-2467813", "R-MMU-8939246", "R-DDI-9603798", "R-RNO-3108214", "R-SPO-9664873", "R-BTA-9033241", "R-SPO-5696395", "R-RNO-212676", "R-BTA-9758274", "R-HSA-75953", "R-CEL-4551638", "R-DME-8948747", "R-MMU-9929356", "R-HSA-77075", "R-BTA-8953750", "R-MMU-5250924", "R-BTA-174084", "R-DDI-73779", "R-BTA-2559582", "R-DDI-8948751", "R-HSA-5675482", "R-DDI-174048", "R-SCE-76042", "R-MMU-9708530", "R-DME-6807505", "R-DDI-450302", "R-HSA-9013695", "R-DRE-209543", "R-BTA-193692", "R-HSA-5620920", "R-RNO-450302", "R-HSA-1632852", "R-DME-209447", "R-HSA-3134973", "R-HSA-3371378", "R-MMU-400206", "R-DDI-176408", "R-DDI-6782135", "R-DRE-937072", "R-MMU-8863795", "R-MMU-933541", "R-SPO-6811555", "R-MMU-9013148", "R-BTA-3108214", "R-RNO-8939246", "R-RNO-114608", "R-CFA-5689880", "R-DRE-5696395", "R-HSA-9754560", "R-HSA-918233", "R-DME-2559580", "R-MMU-937039", "R-CEL-3232142", "R-DME-3899300", "R-RNO-212436", "R-MMU-5658442", "R-DRE-5689896", "R-MMU-168638", "R-HSA-174084", "R-DRE-9843940", "R-RNO-8856825", "R-RNO-166058", "R-DME-5675482", "R-HSA-73762", "R-MMU-1169408", "R-SSC-5357956", "R-HSA-975155", "R-HSA-9706377", "R-SCE-4551638", "R-RNO-2559580", "R-HSA-69017", "R-BTA-9020702", "R-RNO-1234158", "R-HSA-9014325", "R-XTR-6807505", "R-MMU-4755510", "R-DDI-450321", "R-DDI-174154", "R-RNO-2871837", "R-CEL-8939243", "R-CFA-8953750", "R-MMU-2173795", "R-RNO-917729", "R-MMU-9933946", "R-MMU-8941858", "R-MMU-917729", "R-RNO-73779", "R-SSC-209543", "R-HSA-264876", "R-MMU-174154", "R-MMU-937072", "R-RNO-382556", "R-SPO-6781823", "R-SSC-5357905", "R-HSA-5693565", "R-BTA-975144", "R-MMU-5689896", "R-XTR-209543", "R-MMU-9706019", "R-DME-5689896", "R-DRE-445989", "R-HSA-6804759", "R-RNO-9033241", "R-DME-390150", "R-HSA-2979096", "R-HSA-73776", "R-BTA-77075", "R-RNO-1632852", "R-MMU-5668541", "R-HSA-9693928", "R-CEL-75953", "R-SCE-9033241", "R-HSA-5610783", "R-SSC-450321", "R-HSA-2122947", "R-HSA-9614657", "R-BTA-68867", "R-CEL-4085377", "R-HSA-9603798", "R-MMU-195253", "R-HSA-9617629", "R-BTA-8856828", "R-MMU-382556", "R-RNO-113418", "R-DME-209360", "R-MMU-212676", "R-RNO-9856649", "R-HSA-156711", "R-MMU-8866907", "R-XTR-9645460", "R-MMU-1660499", "R-SSC-202424", "R-MMU-8943724", "R-DME-8854050", "R-HSA-5693571", "R-HSA-9909649", "R-DRE-4090294", "R-RNO-8866907", "R-HSA-5696400", "R-BTA-6807505", "R-DDI-8854050", "R-MMU-8953750", "R-DDI-354192", "R-HSA-1606341", "R-BTA-9013424", "R-MMU-5607764", "R-DRE-198323", "R-RNO-8939243", "R-SSC-6811558", "R-DRE-6807505", "R-DDI-9020702", "R-HSA-141430", "R-DME-111465", "R-HSA-9635644", "R-HSA-9649948", "R-HSA-3322077", "R-MMU-1660514", "R-MMU-975163", "R-MMU-5693568", "R-HSA-8878166", "R-CEL-9013148", "R-HSA-5655302", "R-HSA-4551638", "R-MMU-76042", "R-HSA-176408", "R-RNO-3899300", "R-DDI-193648", "R-CEL-4641258", "R-BTA-937042", "R-DME-5689877", "R-CEL-9833482", "R-SSC-5676594", "R-DME-3769402", "R-HSA-9013149", "R-HSA-5658442", "R-MMU-203754", "R-SCE-674695", "R-HSA-3134975", "R-HSA-9613829", "R-XTR-975163", "R-HSA-110314", "R-GGA-3899300", "R-HSA-5689901", "R-HSA-8853884", "R-RNO-8943724", "R-SPO-176408", "R-HSA-901032", "R-DRE-4615885", "R-RNO-201722", "R-HSA-209543", "R-DME-5610780", "R-DME-195253", "R-MMU-69601", "R-MMU-9670095", "R-HSA-3214841", "R-DDI-975163", "R-HSA-1236382", "R-MMU-8854050", "R-CEL-3214842", "R-HSA-9029569", "R-HSA-5656169", "R-HSA-937072", "R-HSA-5607764", "R-MMU-1358803", "R-SCE-6796648", "R-RNO-8948747", "R-CEL-1234158", "R-HSA-193648", "R-MMU-3769402", "R-SPO-3108214", "R-DME-9033241", "R-RNO-6782135", "R-SCE-113418", "R-DRE-4755510", "R-HSA-9933939", "R-XTR-9013424", "R-MMU-181429", "R-CEL-68949", "R-HSA-5687128", "R-BTA-450302", "R-CEL-1660499", "R-MMU-6811555", "R-RNO-5357956", "R-HSA-110320", "R-BTA-975163"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8951664:r:Neddylation", "R-MMU-1632852:r:Macroautophagy", "R-SSC-193692:r:Regulated proteolysis of p75NTR", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DRE-2559585:r:Oncogene Induced Senescence", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-CEL-4090294:r:SUMOylation of intracellular receptors", "R-CEL-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-DRE-3232118:r:SUMOylation of transcription factors", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-72086:r:mRNA Capping", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-CEL-9031628:r:NGF-stimulated transcription", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-9013420:r:RHOU GTPase cycle", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-MMU-5620920:r:Cargo trafficking to the periciliary membrane", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-429947:r:Deadenylation of mRNA", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-XTR-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-5689880:r:Ub-specific processing proteases", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-877312:r:Regulation of IFNG signaling", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-SSC-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-RNO-9020702:r:Interleukin-1 signaling", "R-XTR-209560:r:NF-kB is activated and signals survival", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-SSC-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-XTR-8948751:r:Regulation of PTEN stability and activity", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-SPO-72086:r:mRNA Capping", "R-XTR-5689880:r:Ub-specific processing proteases", "R-HSA-1266695:r:Interleukin-7 signaling", "R-DRE-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-72086:r:mRNA Capping", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-209421:r:Transcription activation by ARM", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-DDI-5620920:r:Cargo trafficking to the periciliary membrane", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DME-216167:r:Nuclear CI is degraded", "R-XTR-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5334118:r:DNA methylation", "R-BTA-9013420:r:RHOU GTPase cycle", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-SCE-72086:r:mRNA Capping", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-GGA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-3214815:r:HDACs deacetylate histones", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-5673000:r:RAF activation", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-9646399:r:Aggrephagy", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-DDI-9033241:r:Peroxisomal protein import", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-6782135:r:Dual incision in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-GGA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-DRE-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-8951664:r:Neddylation", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-9833482:r:PKR-mediated signaling", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-68949:r:Orc1 removal from chromatin", "R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-GGA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-69541:r:Stabilization of p53", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-SSC-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-SCE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-XTR-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-912631:r:Regulation of signaling by CBL", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-3214842:r:HDMs demethylate histones", "R-MMU-9706369:r:Negative regulation of FLT3", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-3214847:r:HATs acetylate histones", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-5696400:r:Dual Incision in GG-NER", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-182971:r:EGFR downregulation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-69541:r:Stabilization of p53", "R-HSA-75893:r:TNF signaling", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DRE-3214847:r:HATs acetylate histones", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-HSA-3214815:r:HDACs deacetylate histones", "R-RNO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-212436:r:Generic Transcription Pathway", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-4641258:r:Degradation of DVL", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-GGA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DME-111469:r:SMAC, XIAP-regulated apoptotic response", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-3371568:r:Attenuation phase", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-SSC-5689880:r:Ub-specific processing proteases", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-DME-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-SCE-3214842:r:HDMs demethylate histones", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-9646399:r:Aggrephagy", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-210991:r:Basigin interactions", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DRE-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-MMU-5673000:r:RAF activation", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-69416:r:Dimerization of procaspase-8", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-201451:r:Signaling by BMP", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9839394:r:TGFBR3 expression", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-SCE-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CFA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-4641263:r:Regulation of FZD by ubiquitination", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-SSC-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-GGA-3214847:r:HATs acetylate histones", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-6804758:r:Regulation of TP53 Activity through Acetylation", "R-SPO-69202:r:Cyclin E associated events during G1/S transition", "R-GGA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-3232118:r:SUMOylation of transcription factors", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-CFA-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5689603:r:UCH proteinases", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-209560:r:NF-kB is activated and signals survival", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-DME-114608:r:Platelet degranulation", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-69416:r:Dimerization of procaspase-8", "R-HSA-167161:r:HIV Transcription Initiation", "R-MMU-9646399:r:Aggrephagy", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-9031628:r:NGF-stimulated transcription", "R-XTR-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-SCE-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-203754:r:NOSIP mediated eNOS trafficking", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-DME-9646399:r:Aggrephagy", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-SSC-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-MMU-6807004:r:Negative regulation of MET activity", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-DME-9013420:r:RHOU GTPase cycle", "R-XTR-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-8951664:r:Neddylation", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-9766229:r:Degradation of CDH1", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-CFA-69541:r:Stabilization of p53", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9663199:r:Defective DNA double strand break response due to BRCA1 loss of function", "R-MMU-75893:r:TNF signaling", "R-DRE-3214842:r:HDMs demethylate histones", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-114608:r:Platelet degranulation", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-XTR-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-SSC-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-68949:r:Orc1 removal from chromatin", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-CFA-9766229:r:Degradation of CDH1", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DDI-171007:r:p38MAPK events", "R-HSA-8948747:r:Regulation of PTEN localization", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-912631:r:Regulation of signaling by CBL", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CFA-2559585:r:Oncogene Induced Senescence", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-MMU-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-MMU-3371511:r:HSF1 activation", "R-CEL-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DRE-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-RNO-182971:r:EGFR downregulation", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-9706019:r:RHOBTB3 ATPase cycle", "R-SSC-937039:r:IRAK1 recruits IKK complex", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SCE-114608:r:Platelet degranulation", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SCE-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-5673000:r:RAF activation", "R-GGA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-429947:r:Deadenylation of mRNA", "R-CEL-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-9031628:r:NGF-stimulated transcription", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-DME-182971:r:EGFR downregulation", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-9699150:r:Defective DNA double strand break response due to BARD1 loss of function", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-5689896:r:Ovarian tumor domain proteases", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-4641257:r:Degradation of AXIN", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-SSC-9020702:r:Interleukin-1 signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-SPO-69231:r:Cyclin D associated events in G1", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DDI-392517:r:Rap1 signalling", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-RNO-6807004:r:Negative regulation of MET activity", "R-SPO-9033241:r:Peroxisomal protein import", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-3214847:r:HATs acetylate histones", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DDI-9646399:r:Aggrephagy", "R-MMU-69541:r:Stabilization of p53", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-DDI-5632684:r:Hedgehog 'on' state", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-SCE-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-3371511:r:HSF1 activation", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DRE-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-9833110:r:RSV-host interactions", "R-CEL-3214847:r:HATs acetylate histones", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-RNO-4755510:r:SUMOylation of immune response proteins", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-3371568:r:Attenuation phase", "R-BTA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9707616:r:Heme signaling", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-209407:r:Transport of ARM to the nucleus", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-MMU-1433559:r:Regulation of KIT signaling", "R-GGA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-XTR-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-SSC-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DRE-9020702:r:Interleukin-1 signaling", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-212436:r:Generic Transcription Pathway", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-9770562:r:mRNA Polyadenylation", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-MMU-114608:r:Platelet degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-114608:r:Platelet degranulation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-CFA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-6807004:r:Negative regulation of MET activity", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-RNO-72086:r:mRNA Capping", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-445355:r:Smooth Muscle Contraction", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-1059683:r:Interleukin-6 signaling", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-69541:r:Stabilization of p53", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DDI-1169092:r:Activation of RAS in B cells", "R-DRE-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-210991:r:Basigin interactions", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-XTR-202424:r:Downstream TCR signaling", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-3371378:r:Regulation by c-FLIP", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DRE-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DRE-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-182971:r:EGFR downregulation", "R-BTA-182971:r:EGFR downregulation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-RNO-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DDI-3371511:r:HSF1 activation", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-MMU-3371568:r:Attenuation phase", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9670613:r:Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-3214815:r:HDACs deacetylate histones", "R-DRE-937039:r:IRAK1 recruits IKK complex", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-9031628:r:NGF-stimulated transcription", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9670615:r:Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-DME-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-BTA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-201451:r:Signaling by BMP", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-912446:r:Meiotic recombination", "R-CFA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-210744:r:Regulation of gene expression in late 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"R-HSA-6804116", "R-HSA-1989781", "R-HSA-6804115", "R-MMU-72203", "R-HSA-8939256", "R-HSA-9700645", "R-SCE-75953", "R-MMU-113418", "R-DRE-5632684", "R-HSA-9758919", "R-BTA-76042", "R-RNO-73863", "R-HSA-9013424", "R-MMU-69541", "R-DRE-3214815", "R-HSA-1368108", "R-DRE-6807505", "R-DRE-4641262", "R-HSA-8941855", "R-MMU-3232118", "R-HSA-9926550", "R-DME-6804758", "R-MMU-73779", "R-CEL-9762293", "R-HSA-9690406", "R-HSA-9018519", "R-MMU-76042", "R-DME-6804759", "R-SPO-75953", "R-MMU-8936459", "R-CEL-6807505", "R-HSA-193670", "R-RNO-72203", "R-RNO-76042", "R-HSA-9830364", "R-CEL-3232118", "R-MMU-73856", "R-HSA-3214815", "R-CEL-113418", "R-DDI-72086", "R-HSA-6785807", "R-RNO-9933937", "R-MMU-674695", "R-MMU-9018519", "R-HSA-9013149", "R-HSA-8980692", "R-DME-9843940", "R-SCE-674695", "R-DME-5610785", "R-RNO-9843940", "R-HSA-5689603", "R-MMU-6782210", "R-RNO-5689896", "R-GGA-3232118", "R-RNO-983168", "R-CEL-6796648", "R-HSA-5617472", "R-HSA-8876725", "R-MMU-73762", "R-MMU-212436", "R-MMU-6782135", "R-MMU-9933937", "R-HSA-2559585", "R-DME-5610780", "R-HSA-9619665", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-MMU-212300", "R-HSA-3214858", "R-RNO-3214815", "R-DME-209214", "R-HSA-167162", "R-HSA-9827857", "R-CEL-8943724", "R-HSA-3214841", "R-MMU-5610785", "R-HSA-167152", "R-DME-209159", "R-HSA-8866910", "R-HSA-9845323", "R-HSA-77588", "R-DME-3232118", "R-SPO-983168", "R-HSA-111367", "R-SPO-3214858", "R-MMU-5689603", "R-BTA-5696395", "R-SCE-6782210", "R-HSA-9918481", "R-HSA-2173796", "R-BTA-6796648", "R-BTA-212300", "R-HSA-9762293", "R-SCE-6796648", "R-HSA-193648", "R-SPO-77075", "R-HSA-9013508", "R-RNO-73772", "R-BTA-5689896", "R-CEL-9913351", "R-HSA-5083635", "R-RNO-6782135", "R-SCE-113418", "R-MMU-73863", "R-HSA-9933939", "R-HSA-6782135", "R-HSA-9679191", "R-MMU-9764725", "R-HSA-9830674", "R-DME-5632684", "R-DRE-3214841", "R-SPO-5696400", "R-DME-8936459", "R-HSA-6803204", "R-DRE-9954716", "R-MMU-983168", "R-HSA-9831926", "R-DDI-75953", "R-HSA-2892247", "R-CEL-76042", "R-RNO-9031628", "R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-DME-216217", "R-HSA-8951664", "R-MMU-9770562", "R-HSA-8936459", "R-MMU-69895", "R-DDI-73776", "R-RNO-72163", "R-DDI-6782210", "R-SPO-9930044", "R-HSA-9617828", "R-RNO-9018519", "R-CEL-532668", "R-DME-5696394", "R-RNO-73776", "R-HSA-9818030", "R-HSA-9844594", "R-HSA-6804754", "R-MMU-5610787", "R-DME-214869", "R-MMU-76061", "R-DME-8941855", "R-MMU-5696394", "R-SPO-6796648", "R-DME-214842", "R-HSA-749476", "R-CEL-73776", "R-HSA-9834899", "R-BTA-75955", "R-HSA-168138", "R-MMU-9934037", "R-DME-9772755", "R-SPO-9018519", "R-MMU-2173796", "R-RNO-5696395", "R-HSA-452723", "R-RNO-3214841", "R-CEL-674695", "R-HSA-72163", "R-DME-214874", "R-RNO-9764725", "R-RNO-76061", "R-HSA-909733", "R-CEL-112382", "R-CEL-6782135", "R-HSA-6804114", "R-HSA-3232118", "R-MMU-111367", "R-SPO-73779", "R-SPO-8951664", "R-BTA-6782210", "R-DDI-113418", "R-MMU-72086", "R-CEL-9031628", "R-SPO-73776", "R-SCE-983231", "R-DME-9933946", "R-SCE-5689896", "R-HSA-5660489", "R-DDI-5696395", "R-MMU-5674135", "R-HSA-9735871", "R-HSA-6803205"], "pathways": ["R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-912446:r:Meiotic recombination", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8941855:r:RUNX3 regulates CDKN1A transcription", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-3214847:r:HATs acetylate histones", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9768777:r:Regulation of NPAS4 gene transcription", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9707616:r:Heme signaling", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-DME-209446:r:N-HH ligand not bound to PTC receptor complex", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9761174:r:Formation of intermediate mesoderm", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-HSA-212436:r:Generic Transcription Pathway", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-3238698:r:WNT ligand biogenesis and trafficking", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-BTA-72086:r:mRNA Capping", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9823739:r:Formation of the anterior neural plate", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-5635851:r:GLI proteins bind promoters of Hh responsive genes to promote transcription", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-DME-5689603:r:UCH proteinases", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-212436:r:Generic Transcription Pathway", "R-DME-216167:r:Nuclear CI is degraded", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-DME-209190:r:Phosphorylation of CI", "R-RNO-72086:r:mRNA Capping", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-SCE-72086:r:mRNA Capping", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-69541:r:Stabilization of p53", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-9633012:r:Response of EIF2AK4 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"R-DME-9749641", "R-DME-1307965", "R-HSA-9926550", "R-MMU-5654732", "R-RNO-9026527", "R-MMU-5658623", "R-HSA-9664565", "R-CEL-5654693", "R-CEL-190322", "R-DRE-5654727", "R-DRE-5654706", "R-DME-1236394", "R-CEL-190375", "R-MMU-390522", "R-HSA-5654732", "R-HSA-2219530", "R-MMU-445144", "R-HSA-6785807", "R-DME-5654688", "R-RNO-77387", "R-DRE-210993", "R-RNO-418885", "R-HSA-9013404", "R-DME-445144", "R-HSA-9620244", "R-RNO-1358803", "R-DME-1963640", "R-HSA-376172", "R-HSA-5654733", "R-RNO-8849932", "R-RNO-4420097", "R-DRE-190370", "R-MMU-419037", "R-RNO-6785631", "R-DME-5654720", "R-HSA-418889", "R-HSA-418886", "R-HSA-977443", "R-MMU-9010553", "R-HSA-418885", "R-HSA-2559582", "R-HSA-1250342", "R-BTA-114608", "R-CEL-1474228", "R-RNO-418889", "R-DME-9913351", "R-GGA-6811558", "R-RNO-373752", "R-RNO-170984", "R-DME-5654221", "R-HSA-9918481", "R-HSA-5658623", "R-DRE-5654693", "R-CEL-9913351", "R-DME-376172", "R-DRE-9013408", "R-HSA-5083635", "R-HSA-428542", "R-HSA-4086400", "R-DME-5654228", "R-HSA-190373", "R-MMU-8985586", "R-HSA-9032500", "R-CEL-190372", "R-DME-8849932", "R-HSA-8985586", "R-HSA-428543", "R-CEL-1971475", "R-MMU-9013026", "R-DME-3000171", "R-RNO-1250196", "R-DME-5654726", "R-DRE-5654719", "R-MMU-9026527", "R-MMU-1250342", "R-RNO-1250347", "R-GGA-1963642", "R-RNO-9013409", "R-MMU-6811558", "R-MMU-433692", "R-RNO-187042", "R-HSA-1306955", "R-MMU-418889", "R-DRE-388844", "R-HSA-5632681", "R-HSA-8863795", "R-MMU-1236394", "R-RNO-193648", "R-MMU-186763", "R-HSA-210991", "R-CEL-428542", "R-MMU-9035034", "R-DME-210991", "R-DME-109704", "R-DME-6785631", "R-HSA-437239", "R-RNO-9013148", "R-DME-190377", "R-MMU-5140745", "R-HSA-419037", "R-HSA-163125", "R-DME-216083", "R-HSA-9820960", "R-MMU-5654219", "R-MMU-1963642", "R-MMU-216083", "R-RNO-388844", "R-DME-416700", "R-MMU-5654712", "R-CEL-6811558", "R-RNO-5654712", "R-MMU-5654227", "R-RNO-216083", "R-DME-1971475", "R-HSA-1251985", "R-RNO-8980692", "R-RNO-1257604", "R-CEL-5654720", "R-DRE-9013404", "R-HSA-8849932", "R-CEL-2024096", "R-DRE-5654221", "R-RNO-5654719", "R-RNO-416482", "R-CEL-5654712", "R-RNO-3928662", "R-HSA-190372", "R-HSA-5655332", "R-DME-5654719", "R-HSA-109704", "R-MMU-1227986", "R-HSA-6785631", "R-HSA-9034864", "R-HSA-190371", "R-MMU-1257604", "R-BTA-8849932", "R-RNO-5632681", "R-HSA-1358803", "R-MMU-190371", "R-HSA-6807004", "R-HSA-8853336", "R-DRE-190374", "R-DME-209968", "R-HSA-5173214", "R-RNO-9032759", "R-MMU-5654727", "R-CEL-8941413", "R-HSA-428540", "R-DRE-4420097", "R-HSA-8853333", "R-MMU-1963640", "R-CEL-2022928", "R-MMU-9013106", "R-HSA-5654228", "R-MMU-373756", "R-GGA-1227986", "R-HSA-9026519", "R-CEL-5673001", "R-DRE-5673001", "R-MMU-5654695", "R-CEL-5654732", "R-RNO-170968", "R-CEL-5654228", "R-HSA-9673767", "R-RNO-9013408", "R-HSA-2023837", "R-RNO-5673001", "R-DME-5654227", "R-CEL-525793", "R-HSA-373753", "R-HSA-447043", "R-DME-5654704", "R-MMU-5635838", "R-HSA-9034793", "R-HSA-9694614", "R-HSA-9673768", "R-HSA-194306", "R-HSA-5218921", "R-MMU-373753", "R-MMU-198933", "R-DRE-5654704", "R-HSA-5635838", "R-MMU-9013406", "R-MMU-6798695", "R-RNO-376172", "R-MMU-9034013", "R-RNO-194306", "R-GGA-1306955", "R-HSA-1839128", "R-DRE-9013423", "R-DME-419037", "R-DME-5654700", "R-HSA-977225", "R-RNO-109704", "R-HSA-375165", "R-DRE-5654219", "R-GGA-8863795", "R-CEL-5654706", "R-CEL-5654699", "R-DRE-9013149", "R-RNO-1307965", "R-DME-1250347", "R-HSA-525793", "R-HSA-1839122", "R-CEL-210991", "R-HSA-445355", "R-HSA-373756", "R-HSA-5654706", "R-RNO-186797", "R-DME-5654689", "R-HSA-1227986", "R-HSA-5654227", "R-DRE-9013148", "R-DRE-190375", "R-HSA-5627123", "R-MMU-416482", "R-MMU-5654733", "R-DME-190373", "R-HSA-8957275", "R-DRE-5654695", "R-MMU-418885", "R-HSA-9013409", "R-RNO-445095", "R-HSA-2243919", "R-MMU-210991", "R-DRE-186797", "R-HSA-3000178", "R-HSA-3560783", "R-HSA-9918485", "R-MMU-9013408", "R-RNO-373753", "R-CEL-3000178", "R-HSA-9856532", "R-HSA-3656237", "R-DME-5654732", "R-RNO-8863795", "R-HSA-9674401", "R-MMU-5632681", "R-DRE-6811558", "R-CEL-190373", "R-HSA-5140745", "R-MMU-5673001", "R-HSA-9026527", "R-DME-190370", "R-HSA-182971", "R-RNO-445144", "R-HSA-9674396", "R-HSA-416482", "R-DME-433692", "R-MMU-190372", "R-HSA-447041", "R-RNO-5654688", "R-DME-5654695", "R-MMU-193648", "R-HSA-9793380", "R-HSA-445144", "R-MMU-5627123", "R-CEL-8849932", "R-HSA-5655253", "R-DME-1358803", "R-DME-5673001", "R-GGA-163125", "R-MMU-8980692", "R-HSA-373760", "R-MMU-388844", "R-HSA-9013423", "R-DRE-190377", "R-HSA-190374", "R-MMU-190370", "R-CEL-190377", "R-CEL-2243919", "R-MMU-1250347", "R-CEL-373752", "R-HSA-1250196", "R-HSA-9674404", "R-HSA-2022928", "R-DRE-195399", "R-GGA-1250196", "R-MMU-437239", "R-HSA-5655291", "R-MMU-109704", "R-DRE-5654227", "R-RNO-1250342", "R-MMU-9028731", "R-RNO-447043", "R-HSA-376176", "R-RNO-1227986", "R-DME-1474228", "R-DME-8941413", "R-GGA-1250347", "R-HSA-5654219", "R-CEL-5654689", "R-HSA-187024", "R-MMU-5654689", "R-HSA-9674428", "R-GGA-1236394", "R-DME-5654706", "R-GGA-1250342", "R-CEL-433692"], "pathways": ["R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-373753:r:Nephrin family interactions", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-CEL-190370:r:FGFR1b ligand binding and activation", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-177929:r:Signaling by EGFR", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-GGA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", "R-DRE-190373:r:FGFR1c ligand binding and activation", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DRE-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-376172:r:DSCAM interactions", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-433692:r:Proton-coupled monocarboxylate transport", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-3000157:r:Laminin interactions", "R-CEL-416700:r:Other semaphorin interactions", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-418885:r:DCC mediated attractive signaling", "R-HSA-9833110:r:RSV-host interactions", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-210991:r:Basigin interactions", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-77387:r:Insulin receptor recycling", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-9830674:r:Formation of the ureteric bud", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-DME-2022928:r:HS-GAG biosynthesis", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416476:r:G alpha (q) signalling events", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-RNO-186763:r:Downstream signal transduction", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-190322:r:FGFR4 ligand binding and activation", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8951664:r:Neddylation", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DME-3000178:r:ECM proteoglycans", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-RNO-416476:r:G alpha (q) signalling events", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-186763:r:Downstream signal transduction", "R-HSA-373752:r:Netrin-1 signaling", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DRE-109704:r:PI3K Cascade", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-GGA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-114608:r:Platelet degranulation", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-CEL-9749641:r:Aspirin ADME", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9014843:r:Interleukin-33 signaling", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-193648:r:NRAGE signals death through JNK", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-186797:r:Signaling by PDGF", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-RNO-198203:r:PI3K/AKT activation", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-2172127:r:DAP12 interactions", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-373753:r:Nephrin family interactions", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-BTA-445355:r:Smooth Muscle Contraction", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-CEL-419037:r:NCAM1 interactions", "R-CEL-209968:r:Thyroxine biosynthesis", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-373760:r:L1CAM interactions", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-2024096:r:HS-GAG degradation", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-DME-2024096:r:HS-GAG degradation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-390522:r:Striated Muscle Contraction", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-CEL-445144:r:Signal transduction by L1", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-186763:r:Downstream signal transduction", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-1236394:r:Signaling by ERBB4", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-390522:r:Striated Muscle Contraction", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-CEL-376176:r:Signaling by ROBO receptors", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-445355:r:Smooth Muscle Contraction", "R-RNO-525793:r:Myogenesis", "R-GGA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-447038:r:NrCAM interactions", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-447043:r:Neurofascin interactions", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-433692:r:Proton-coupled monocarboxylate transport", "R-RNO-8951664:r:Neddylation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-77387:r:Insulin receptor recycling", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-2172127:r:DAP12 interactions", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DME-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-MMU-447043:r:Neurofascin interactions", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-419037:r:NCAM1 interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-373760:r:L1CAM interactions", "R-MMU-182971:r:EGFR downregulation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DME-9749641:r:Aspirin ADME", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-CEL-190322:r:FGFR4 ligand binding and activation", "R-DRE-5654727:r:Negative regulation of FGFR2 signaling", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-DME-1236394:r:Signaling by ERBB4", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-77387:r:Insulin receptor recycling", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9620244:r:Long-term potentiation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-376172:r:DSCAM interactions", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-190370:r:FGFR1b ligand binding and activation", "R-MMU-419037:r:NCAM1 interactions", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-977443:r:GABA receptor activation", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-BTA-114608:r:Platelet degranulation", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-373752:r:Netrin-1 signaling", "R-RNO-170984:r:ARMS-mediated activation", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-376172:r:DSCAM interactions", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-4086400:r:PCP/CE pathway", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-433692:r:Proton-coupled monocarboxylate transport", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-5632681:r:Ligand-receptor interactions", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-1236394:r:Signaling by ERBB4", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-210991:r:Basigin interactions", "R-CEL-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-210991:r:Basigin interactions", "R-DME-109704:r:PI3K Cascade", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-437239:r:Recycling pathway of L1", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-416700:r:Other semaphorin interactions", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-216083:r:Integrin cell surface interactions", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-2024096:r:HS-GAG degradation", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-209968:r:Thyroxine biosynthesis", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-428540:r:Activation of RAC1", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-373756:r:SDK interactions", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-170968:r:Frs2-mediated activation", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-CEL-525793:r:Myogenesis", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-447043:r:Neurofascin interactions", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-5635838:r:Activation of SMO", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-5635838:r:Activation of SMO", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-376172:r:DSCAM interactions", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-GGA-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-DME-419037:r:NCAM1 interactions", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-109704:r:PI3K Cascade", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-525793:r:Myogenesis", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-CEL-210991:r:Basigin interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-373756:r:SDK interactions", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-186797:r:Signaling by PDGF", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-MMU-210991:r:Basigin interactions", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-373753:r:Nephrin family interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-MMU-5632681:r:Ligand-receptor interactions", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-HSA-182971:r:EGFR downregulation", "R-RNO-445144:r:Signal transduction by L1", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-HSA-447041:r:CHL1 interactions", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-373752:r:Netrin-1 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-9674404:r:Sorafenib-resistant PDGFR mutants", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-GGA-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-437239:r:Recycling pathway of L1", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-109704:r:PI3K Cascade", "R-DRE-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-RNO-447043:r:Neurofascin interactions", "R-HSA-376176:r:Signaling by ROBO receptors", "R-RNO-1227986:r:Signaling by ERBB2", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-HSA-187024:r:NGF-independant TRKA activation", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-GGA-1236394:r:Signaling by ERBB4", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-GGA-1250342:r:PI3K events in ERBB4 signaling", "R-CEL-433692:r:Proton-coupled monocarboxylate transport"], "type": "Domain"}, "IPR013099": {"description": "Potassium channel domain", "go_ids": [], "go_terms": [], "name": "K_chnl_dom", "pathway_ids": ["R-RNO-1299344", "R-DME-1299503", "R-HSA-1299287", "R-MMU-1299287", "R-SCE-1299503", "R-MMU-1299316", "R-RNO-1299503", "R-HSA-9667769", "R-SCE-5576886", "R-HSA-1299316", "R-CEL-1296052", "R-HSA-5576886", "R-CEL-1299316", "R-HSA-1299503", "R-RNO-1299287", "R-MMU-1299503", "R-SCE-1299361", "R-DME-1296052", "R-PFA-5576890", "R-DME-5576886", "R-CEL-5576886", "R-MMU-1299361", "R-HSA-1299308", "R-SCE-1299316", "R-SSC-1296052", "R-RNO-1299308", "R-HSA-1299344", "R-HSA-1299361", "R-CEL-1299344", "R-CEL-1299503", "R-BTA-1299308", "R-MMU-1299308", "R-MMU-5576886", "R-MMU-1296052", "R-PFA-381676", "R-RNO-5576886", "R-PFA-1300642", "R-DME-1299344", "R-HSA-1296052", "R-BTA-5576886", "R-MMU-1299344", "R-RNO-1299316", "R-SCE-1299344", "R-RNO-1296052", "R-SCE-1299308", "R-SCE-1299287"], "pathways": ["R-RNO-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-DME-1299503:r:TWIK related potassium channel (TREK)", "R-HSA-1299287:r:Tandem pore domain halothane-inhibited K+ channel (THIK)", "R-MMU-1299287:r:Tandem pore domain halothane-inhibited K+ channel (THIK)", "R-SCE-1299503:r:TWIK related potassium channel (TREK)", "R-MMU-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-RNO-1299503:r:TWIK related potassium channel (TREK)", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-SCE-5576886:r:Phase 4 - resting membrane potential", "R-HSA-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-CEL-1296052:r:Ca2+ activated K+ channels", "R-HSA-5576886:r:Phase 4 - resting membrane potential", "R-CEL-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-HSA-1299503:r:TWIK related potassium channel (TREK)", "R-RNO-1299287:r:Tandem pore domain halothane-inhibited K+ channel (THIK)", "R-MMU-1299503:r:TWIK related potassium channel (TREK)", "R-SCE-1299361:r:TWIK-related alkaline pH activated K+ channel (TALK)", "R-DME-1296052:r:Ca2+ activated K+ channels", "R-PFA-5576890:r:Phase 3 - rapid repolarisation", "R-DME-5576886:r:Phase 4 - resting membrane potential", "R-CEL-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1299361:r:TWIK-related alkaline pH activated K+ channel (TALK)", "R-HSA-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-SCE-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-SSC-1296052:r:Ca2+ activated K+ channels", "R-RNO-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-HSA-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-HSA-1299361:r:TWIK-related alkaline pH activated K+ channel (TALK)", "R-CEL-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-CEL-1299503:r:TWIK related potassium channel (TREK)", "R-BTA-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-MMU-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-MMU-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296052:r:Ca2+ activated K+ channels", "R-PFA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-5576886:r:Phase 4 - resting membrane potential", "R-PFA-1300642:r:Sperm Motility And Taxes", "R-DME-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-HSA-1296052:r:Ca2+ activated K+ channels", "R-BTA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-RNO-1299316:r:TWIK-releated acid-sensitive K+ channel (TASK)", "R-SCE-1299344:r:TWIK-related spinal cord K+ channel (TRESK)", "R-RNO-1296052:r:Ca2+ activated K+ channels", "R-SCE-1299308:r:Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "R-SCE-1299287:r:Tandem pore domain halothane-inhibited K+ channel (THIK)"], "type": "Domain"}, "IPR013100": {"description": "Limonene-1,2-epoxide hydrolase", "go_ids": [], "go_terms": [], "name": "LEH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013101": {"description": "Phosphate response ubiquitin E3 ligase 1-like, LRR", "go_ids": [], "go_terms": [], "name": "LRR_PRU1-like", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR013102": {"description": "Pyrimidine nucleoside phosphorylase, C-terminal", "go_ids": ["GO:0006213", "GO:0016763"], "go_terms": ["GO:0006213:pyrimidine nucleoside metabolic process:P", "GO:0016763:pentosyltransferase activity:F"], "name": "PYNP_C", "pathway_ids": ["PWY-7181", "R-RNO-73621", "R-MMU-73614", "R-HSA-73621", 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"R-HSA-5250971:r:Toxicity of botulinum toxin type C (botC)", "R-HSA-5250982:r:Toxicity of tetanus toxin (tetX)", "R-HSA-5250992:r:Toxicity of botulinum toxin type E (botE)", "R-HSA-5250955:r:Toxicity of botulinum toxin type D (botD)", "R-HSA-5250981:r:Toxicity of botulinum toxin type F (botF)", "R-HSA-5250958:r:Toxicity of botulinum toxin type B (botB)"], "type": "Domain"}, "IPR013105": {"description": "Tetratricopeptide repeat 2", "go_ids": [], "go_terms": [], "name": "TPR_2", "pathway_ids": ["R-MMU-8939211", "R-DDI-2559580", "R-RNO-3371497", "R-HSA-9679191", "R-HSA-3371497", "R-HSA-1169408", "R-RNO-9018519", "R-MMU-9018519", "R-RNO-3371568", "R-MMU-3371568", "R-HSA-909733", "R-HSA-8939211", "R-RNO-8939211", "R-SCE-983168", "R-HSA-3371568", "R-HSA-9018519", "R-PFA-3371497", "R-MMU-3371497", "R-HSA-9696273"], "pathways": ["R-MMU-8939211:r:ESR-mediated signaling", "R-DDI-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors 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{"description": "Immunoglobulin V-set domain", "go_ids": [], "go_terms": [], "name": "Ig_V-set", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-MMU-8856828", "R-RNO-2022923", "R-MMU-6811558", "R-HSA-420029", "R-HSA-2871796", "R-HSA-9010553", "R-DRE-202733", "R-HSA-9010642", "R-DME-3000178", "R-MMU-202430", "R-HSA-418990", "R-BTA-6811558", "R-MMU-202733", "R-DRE-198933", "R-HSA-9931295", "R-MMU-9035034", "R-SSC-2022854", "R-HSA-983695", "R-HSA-2022870", "R-DME-210991", "R-HSA-3000171", "R-HSA-373752", "R-DRE-216083", "R-HSA-419037", "R-RNO-2022857", "R-HSA-163125", "R-HSA-9820960", "R-DME-216083", "R-HSA-3656244", "R-HSA-389356", "R-HSA-3656225", "R-MMU-216083", "R-HSA-180534", "R-HSA-389357", "R-GGA-3000178", "R-RNO-2172127", "R-RNO-216083", "R-DME-1971475", "R-HSA-202433", "R-RNO-1257604", "R-RNO-8980692", "R-CEL-2024096", "R-MMU-173623", "R-HSA-114608", "R-RNO-389359", "R-BTA-9927354", "R-RNO-8856828", "R-RNO-2022870", "R-RNO-8851680", "R-MMU-1566977", "R-XTR-418990", "R-HSA-2871809", "R-HSA-167590", "R-MMU-1257604", "R-MMU-2029481", "R-MMU-389513", "R-RNO-9013423", "R-MMU-2022857", "R-HSA-9725371", "R-HSA-9717207", "R-HSA-8856825", "R-HSA-9854909", "R-RNO-389948", "R-HSA-428540", "R-RNO-2022854", "R-HSA-9909620", "R-HSA-428890", "R-BTA-216083", "R-HSA-975634", "R-HSA-391160", "R-HSA-3595174", "R-HSA-6798695", "R-CEL-2022928", "R-HSA-173623", "R-MMU-9013106", "R-HSA-8856828", "R-CEL-6798695", "R-MMU-2173791", "R-HSA-2029481", "R-SSC-1474228", "R-CEL-5673001", "R-BTA-5576892", "R-CFA-1257604", "R-MMU-389357", "R-RNO-202427", "R-MMU-381426", "R-BTA-2022870", "R-DRE-418990", "R-MMU-2029485", "R-MMU-9929356", "R-RNO-9013408", "R-HSA-9013408", "R-RNO-9013404", "R-RNO-3000178", "R-MMU-2168880", "R-MMU-2022923", "R-RNO-9927354", "R-MMU-1474228", "R-HSA-373753", "R-HSA-9927354", "R-CEL-216083", "R-BTA-198933", "R-HSA-2172127", "R-HSA-451927", "R-HSA-9694614", "R-HSA-2029482", "R-RNO-163125", "R-HSA-194306", "R-RNO-2173791", "R-HSA-3560801", "R-RNO-1462054", "R-HSA-6811558", "R-RNO-381426", "R-MMU-198933", "R-HSA-2022854", "R-MMU-9013406", "R-MMU-420597", "R-MMU-6798695", "R-DRE-420597", "R-MMU-202427", "R-HSA-1257604", "R-RNO-376172", "R-MMU-416700", "R-CEL-419037", "R-DME-419037", "R-HSA-977225", "R-BTA-3000178", "R-RNO-114608", "R-HSA-2871837", "R-MMU-9931295", "R-HSA-3656253", "R-HSA-8877330", "R-HSA-416700", "R-HSA-977606", "R-HSA-9035034", "R-RNO-2024101", "R-HSA-2024096", "R-BTA-2024101", "R-DME-2024096", "R-MMU-389948", "R-RNO-8856825", "R-HSA-216083", "R-HSA-1462054", "R-HSA-2173791", "R-CEL-445144", "R-MMU-428890", "R-MMU-2029482", "R-RNO-1971475", "R-MMU-9927354", "R-MMU-416482", "R-HSA-390522", "R-HSA-8957275", "R-RNO-202430", "R-HSA-9013406", "R-HSA-9664422", "R-HSA-202424", "R-HSA-389948", "R-RNO-449836", "R-HSA-8851680", "R-GGA-198933", "R-HSA-3000178", "R-HSA-3560783", "R-RNO-1474228", "R-HSA-9918485", "R-MMU-9013408", "R-RNO-202433", "R-CEL-3000178", "R-HSA-9856532", "R-HSA-3656237", "R-BTA-8957275", "R-HSA-202427", "R-RNO-6811558", "R-HSA-389359", "R-HSA-166663", "R-MMU-5673001", "R-HSA-9701898", "R-MMU-449836", "R-HSA-173107", "R-HSA-1474228", "R-BTA-1971475", "R-HSA-9931269", "R-HSA-9929491", "R-RNO-1566977", "R-HSA-2424491", "R-SSC-2022857", "R-HSA-1971475", "R-HSA-2022857", "R-HSA-416482", "R-CEL-447043", "R-DME-433692", "R-MMU-5690714", "R-HSA-164939", "R-MMU-9013423", "R-BTA-420029", "R-MMU-376176", "R-HSA-2022923", "R-MMU-193648", "R-HSA-9013026", "R-MMU-2024101", "R-MMU-2730905", "R-HSA-9664323", "R-RNO-6798695", "R-CEL-8849932", "R-XTR-202433", "R-DME-5673001", "R-HSA-445095", "R-RNO-9035034", "R-MMU-8980692", "R-HSA-3595172", "R-HSA-2029485", "R-HSA-9013106", "R-HSA-373760", "R-MMU-2172127", "R-HSA-9013423", "R-HSA-2454202", "R-CFA-6811558", "R-HSA-3595177", "R-HSA-2730905", "R-HSA-2022928", "R-GGA-381426", "R-MMU-202424", "R-HSA-389513", "R-DME-428542", "R-MMU-977606", "R-HSA-8985801", "R-MMU-391160", "R-HSA-376176", "R-HSA-9913351", "R-RNO-391160", "R-HSA-5690714", "R-DME-1474228", "R-MMU-8851680", "R-HSA-877300", "R-BTA-1257604", "R-MMU-9013149", "R-HSA-202733", "R-HSA-182218", "R-CEL-373753", "R-MMU-163125", "R-MMU-389359", "R-DME-375165", "R-HSA-2168880", "R-RNO-9013149", "R-MMU-9013404", "R-MMU-8957275", "R-MMU-2243919", "R-CFA-9927354", "R-MMU-2871796", "R-DME-9749641", "R-MMU-389356", "R-MMU-3000178", "R-RNO-202733", "R-RNO-202424", "R-GGA-8957275", "R-MMU-9929491", "R-HSA-202430", "R-HSA-6783783", "R-HSA-381426", "R-SSC-3000178", "R-RNO-389357", "R-HSA-2024101", "R-MMU-420029", "R-RNO-198933", "R-HSA-2219530", "R-MMU-445144", "R-HSA-6785807", "R-GGA-2132286", "R-MMU-2022854", "R-RNO-420029", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-DME-445144", "R-MMU-2871837", "R-HSA-3656243", "R-MMU-9931269", "R-HSA-4420332", "R-HSA-198933", "R-MMU-376172", "R-MMU-1462054", "R-HSA-376172", "R-GGA-2132263", "R-MMU-419037", "R-MMU-375165", "R-CEL-375165", "R-HSA-449836", "R-MMU-2022870", "R-RNO-420597", "R-MMU-8856825", "R-HSA-3000157", "R-RNO-418990", "R-MMU-9010553", "R-HSA-9619665", "R-HSA-5576892", "R-BTA-202733", "R-CEL-1474228", "R-RNO-8957275", "R-DME-9913351", "R-BTA-381426", "R-HSA-9833110", "R-RNO-9013106", "R-HSA-195399", "R-HSA-420597", "R-HSA-9918481", "R-HSA-193648", "R-MMU-202433", "R-CEL-9913351", "R-BTA-2173791", "R-HSA-1566977", "R-HSA-428542", "R-HSA-9679191", "R-MMU-8985586", "R-MMU-983695", "R-MMU-2454202", "R-RNO-389356", "R-MMU-418990", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-HSA-9929356", "R-DME-2022928", "R-MMU-2871809", "R-CEL-1971475", "R-MMU-9013026", "R-DME-3000171", "R-MMU-2424491", "R-BTA-2022923", "R-MMU-1971475", "R-CEL-3000171"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-420029:r:Tight junction interactions", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DRE-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-DME-3000178:r:ECM proteoglycans", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-418990:r:Adherens junctions interactions", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-DRE-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9035034:r:RHOF GTPase cycle", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-DME-210991:r:Basigin interactions", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-373752:r:Netrin-1 signaling", "R-DRE-216083:r:Integrin cell surface interactions", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-389356:r:Co-stimulation by CD28", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-GGA-3000178:r:ECM proteoglycans", "R-RNO-2172127:r:DAP12 interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-202433:r:Generation of second messenger molecules", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-CEL-2024096:r:HS-GAG degradation", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-XTR-418990:r:Adherens junctions interactions", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-RNO-389948:r:Co-inhibition by PD-1", "R-HSA-428540:r:Activation of RAC1", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-2029481:r:FCGR activation", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-DRE-418990:r:Adherens junctions interactions", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2172127:r:DAP12 interactions", "R-HSA-451927:r:Interleukin-2 family signaling", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-1462054:r:Alpha-defensins", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-376172:r:DSCAM interactions", "R-MMU-416700:r:Other semaphorin interactions", "R-CEL-419037:r:NCAM1 interactions", "R-DME-419037:r:NCAM1 interactions", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-3000178:r:ECM proteoglycans", "R-RNO-114608:r:Platelet degranulation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-2024096:r:HS-GAG degradation", "R-BTA-2024101:r:CS/DS degradation", "R-DME-2024096:r:HS-GAG degradation", "R-MMU-389948:r:Co-inhibition by PD-1", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-1462054:r:Alpha-defensins", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-445144:r:Signal transduction by L1", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-390522:r:Striated Muscle Contraction", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-GGA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-202433:r:Generation of second messenger molecules", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-166663:r:Initial triggering of complement", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-1566977:r:Fibronectin matrix formation", "R-HSA-2424491:r:DAP12 signaling", "R-SSC-2022857:r:Keratan sulfate degradation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-447043:r:Neurofascin interactions", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-164939:r:Nef mediated downregulation of CD28 cell surface expression", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-BTA-420029:r:Tight junction interactions", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-XTR-202433:r:Generation of second messenger molecules", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-373760:r:L1CAM interactions", "R-MMU-2172127:r:DAP12 interactions", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-CEL-373753:r:Nephrin family interactions", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-CFA-9927354:r:Co-stimulation by ICOS", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DME-9749641:r:Aspirin ADME", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-202424:r:Downstream TCR signaling", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-2024101:r:CS/DS degradation", "R-MMU-420029:r:Tight junction interactions", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-2132286:r:Classical antibody-mediated complement activation", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-RNO-420029:r:Tight junction interactions", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-376172:r:DSCAM interactions", "R-MMU-1462054:r:Alpha-defensins", "R-HSA-376172:r:DSCAM interactions", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-MMU-419037:r:NCAM1 interactions", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-449836:r:Other interleukin signaling", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-RNO-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000157:r:Laminin interactions", "R-RNO-418990:r:Adherens junctions interactions", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9833110:r:RSV-host interactions", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-202433:r:Generation of second messenger molecules", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-389356:r:Co-stimulation by CD28", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-2022928:r:HS-GAG biosynthesis", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-2424491:r:DAP12 signaling", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions"], "type": "Domain"}, "IPR013107": {"description": "Acyl-CoA dehydrogenase, C-terminal domain", "go_ids": [], 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"R-DME-210991:r:Basigin interactions", "R-RNO-445144:r:Signal transduction by L1", "R-CEL-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-1566977:r:Fibronectin matrix formation", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-HSA-447041:r:CHL1 interactions", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-DDI-2129379:r:Molecules associated with elastic fibres", "R-MMU-5682910:r:LGI-ADAM interactions", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", 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interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DDI-3000178:r:ECM proteoglycans", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5682910:r:LGI-ADAM interactions", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000157:r:Laminin interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding 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between a Lymphoid and a non-Lymphoid cell", "R-DME-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-CEL-1566977:r:Fibronectin matrix formation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-1566948:r:Elastic fibre formation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-354192:r:Integrin signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-210991:r:Basigin interactions", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DDI-1566977:r:Fibronectin matrix formation", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-8866376:r:Reelin signalling pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR013112": {"description": "Ferric reductase-like, FAD-binding domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Fe_red_FAD-bd_8", "pathway_ids": ["R-HSA-6798695", "R-MMU-1222556", "R-SSC-6798695", "R-SSC-9013404", "R-SSC-209968", "R-BTA-6798695", "R-RNO-9013149", "R-MMU-4420097", "R-MMU-9013404", "R-RNO-3299685", "R-BTA-9013423", "R-HSA-4420097", "R-HSA-9013423", "R-DDI-3299685", "R-RNO-5668599", "R-HSA-209968", "R-BTA-4420097", "R-BTA-3299685", "R-HSA-1222556", "R-MMU-5668599", "R-BTA-1236973", "R-DDI-6798695", "R-SSC-1222556", "R-HSA-3299685", "R-RNO-209968", "R-BTA-1222556", "R-SSC-9013423", "R-SSC-4420097", "R-HSA-1236973", "R-SSC-3299685", "R-MMU-3299685", "R-MMU-1236973", "R-HSA-9673324", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-9013423", "R-HSA-9013149", "R-HSA-9703465", "R-BTA-5668599", "R-SSC-1236973", "R-CFA-209968", "R-DME-209968", "R-BTA-9013404", "R-SSC-9013149", "R-MMU-209968", "R-MMU-6798695", "R-SSC-5668599", "R-MMU-9013149", "R-HSA-9702518", "R-HSA-5668599", "R-CEL-209968"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-6798695:r:Neutrophil degranulation", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-SSC-209968:r:Thyroxine biosynthesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-209968:r:Thyroxine biosynthesis", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-209968:r:Thyroxine biosynthesis", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SSC-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-CFA-209968:r:Thyroxine biosynthesis", "R-DME-209968:r:Thyroxine biosynthesis", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-MMU-209968:r:Thyroxine biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-209968:r:Thyroxine biosynthesis"], "type": "Domain"}, "IPR013113": {"description": "Siderophore-interacting, FAD-binding", "go_ids": [], "go_terms": [], "name": "SIP_FAD-bd", "pathway_ids": ["R-HSA-1222449", "R-HSA-9638334"], "pathways": ["R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-HSA-9638334:r:Iron assimilation using enterobactin"], "type": "Domain"}, "IPR013114": {"description": "Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ", "go_ids": [], "go_terms": [], "name": "FabA_FabZ", "pathway_ids": ["PWY-7664", "PWY-8175", "PWY-7858", "PWY-8174", "PWY-8203", "PWY-7663", "PWYG-321", "PWY-5971", "PWY-7388", "PWY-5973", "PWY-8427", "PWY-5989", "PWY-8279", "PWY-8280", "PWY-6519", "PWY-6282", "PWY-8173"], "pathways": ["PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWYG-321:t:mycolate biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-8279:t:palmitate biosynthesis III", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis"], "type": "Family"}, "IPR013115": {"description": "Histidine biosynthesis HisG, C-terminal", "go_ids": ["GO:0000105", "GO:0000287", "GO:0003879", "GO:0005737"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0000287:magnesium ion binding:F", "GO:0003879:ATP phosphoribosyltransferase activity:F", "GO:0005737:cytoplasm:C"], "name": "HisG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013116": {"description": "Ketol-acid reductoisomerase, N-terminal", "go_ids": [], "go_terms": [], "name": "KARI_N", "pathway_ids": ["PWY-7111", "PWY-5103"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-5103:t:L-isoleucine biosynthesis III"], "type": "Domain"}, "IPR013117": {"description": "Intimin, C-terminal", "go_ids": [], "go_terms": [], "name": "Intimin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013118": {"description": "Mannitol dehydrogenase, C-terminal", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Mannitol_DH_C", "pathway_ids": ["PWY-6531"], "pathways": ["PWY-6531:t:mannitol cycle"], "type": "Domain"}, "IPR013120": {"description": "Fatty acyl-CoA reductase-like, NAD-binding domain", "go_ids": [], "go_terms": [], "name": "FAR_NAD-bd", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-DME-9640463", "R-BTA-9640463", "R-HSA-9640463", "R-MMU-9640463", "R-RNO-9640463"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-DME-9640463:r:Wax biosynthesis", "R-BTA-9640463:r:Wax biosynthesis", "R-HSA-9640463:r:Wax biosynthesis", "R-MMU-9640463:r:Wax biosynthesis", "R-RNO-9640463:r:Wax biosynthesis"], "type": "Domain"}, "IPR013121": {"description": "Ferric reductase-like, NAD binding domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Fe_red_NAD-bd_6", "pathway_ids": ["R-HSA-6798695", "R-MMU-1222556", "R-SSC-6798695", "R-SSC-9013404", "R-SSC-209968", "R-BTA-6798695", "R-RNO-9013149", "R-MMU-4420097", "R-MMU-9013404", "R-RNO-3299685", "R-BTA-9013423", "R-HSA-4420097", "R-HSA-9013423", "R-DDI-3299685", "R-RNO-5668599", "R-HSA-209968", "R-BTA-4420097", "R-BTA-3299685", "R-HSA-1222556", "R-MMU-5668599", "R-BTA-1236973", "R-DDI-6798695", "R-SSC-1222556", "R-HSA-3299685", "R-RNO-209968", "R-BTA-1222556", "R-SSC-9013423", "R-SSC-4420097", "R-HSA-1236973", "R-SSC-3299685", "R-MMU-3299685", "R-MMU-1236973", "R-HSA-9673324", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-9013423", "R-HSA-9013149", "R-HSA-9703465", "R-BTA-5668599", "R-SSC-1236973", "R-CFA-209968", "R-DME-209968", "R-BTA-9013404", "R-SSC-9013149", "R-MMU-209968", "R-MMU-6798695", "R-SSC-5668599", "R-MMU-9013149", "R-HSA-9702518", "R-HSA-5668599", "R-CEL-209968"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-6798695:r:Neutrophil degranulation", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-SSC-209968:r:Thyroxine biosynthesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-209968:r:Thyroxine biosynthesis", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-209968:r:Thyroxine biosynthesis", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SSC-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-CFA-209968:r:Thyroxine biosynthesis", "R-DME-209968:r:Thyroxine biosynthesis", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-MMU-209968:r:Thyroxine biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-209968:r:Thyroxine biosynthesis"], "type": "Domain"}, "IPR013122": {"description": "Polycystin cation channel, PKD1/PKD2", "go_ids": [], "go_terms": [], "name": "PKD1_2_channel", "pathway_ids": ["R-HSA-5620916", "R-DRE-5620916", "R-MMU-5620916", "R-BTA-5620916", "R-MMU-917977", "R-CEL-5620916", "R-HSA-917977", "R-MMU-3295583", "R-HSA-3295583"], "pathways": ["R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Domain"}, "IPR013123": {"description": "RNA 2-O ribose methyltransferase, substrate binding", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "SpoU_subst-bd", "pathway_ids": ["R-HSA-6793080"], "pathways": ["R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Domain"}, "IPR013124": {"description": "Gap junction alpha-1 protein (Cx43), C-terminal", "go_ids": [], "go_terms": [], "name": "Connexin43_C", "pathway_ids": ["R-RNO-190840", "R-HSA-9013409", "R-DRE-196025", "R-BTA-196025", "R-HSA-190840", "R-HSA-190861", "R-HSA-190873", "R-HSA-191650", "R-BTA-9013406", "R-HSA-9856532", "R-RNO-191650", "R-MMU-191650", "R-DRE-191650", "R-BTA-190873", "R-BTA-190861", "R-DRE-9013406", "R-BTA-191650", "R-MMU-190873", "R-RNO-196025", "R-RNO-190873", "R-RNO-9013406", "R-HSA-9705677", "R-HSA-190704", "R-HSA-190827", "R-HSA-196025", "R-BTA-190840", "R-MMU-190840", "R-RNO-190861", "R-MMU-196025", "R-DRE-190861", "R-MMU-9013406", "R-HSA-9013406", "R-DRE-190840", "R-MMU-190861"], "pathways": ["R-RNO-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-DRE-196025:r:Formation of annular gap junctions", "R-BTA-196025:r:Formation of annular gap junctions", "R-HSA-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-190861:r:Gap junction assembly", "R-HSA-190873:r:Gap junction degradation", "R-HSA-191650:r:Regulation of gap junction activity", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-RNO-191650:r:Regulation of gap junction activity", "R-MMU-191650:r:Regulation of gap junction activity", "R-DRE-191650:r:Regulation of gap junction activity", "R-BTA-190873:r:Gap junction degradation", "R-BTA-190861:r:Gap junction assembly", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-BTA-191650:r:Regulation of gap junction activity", "R-MMU-190873:r:Gap junction degradation", "R-RNO-196025:r:Formation of annular gap junctions", "R-RNO-190873:r:Gap junction degradation", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-HSA-190704:r:Oligomerization of connexins into connexons", "R-HSA-190827:r:Transport of connexins along the secretory pathway", "R-HSA-196025:r:Formation of annular gap junctions", "R-BTA-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-MMU-190840:r:Microtubule-dependent 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"R-RNO-450408", "R-BTA-72163", "R-DDI-6798695", "R-HSA-381183", "R-MMU-72163", "R-HSA-432720", "R-DRE-3371453", "R-DDI-8876725", "R-HSA-447041", "R-HSA-72163", "R-MMU-3371568", "R-MMU-9841251", "R-SPO-9841251", "R-MMU-983170", "R-DRE-3371571", "R-CFA-9841251", "R-BTA-9833482", "R-RNO-6798695", "R-MMU-3371497", "R-SCE-3371497", "R-SCE-8876725", "R-SPO-3371453", "R-SSC-6798695", "R-MMU-9837999", "R-SSC-450408", "R-DME-6799198", "R-SCE-6798695", "R-CEL-3371571", "R-RNO-3371497", "R-HSA-3371497", "R-SCE-3371568", "R-MMU-9865881", "R-DRE-72163", "R-HSA-114608", "R-RNO-8856828", "R-HSA-9837999", "R-HSA-9615710", "R-GGA-983170", "R-HSA-3371568", "R-SSC-3371453", "R-MMU-3371453", "R-BTA-8856828", "R-DDI-9837999", "R-HSA-381038", "R-SPO-3371568", "R-HSA-9828642", "R-DDI-3371453", "R-DME-6798695", "R-HSA-9841251", "R-MMU-3371571", "R-CFA-3371568", "R-HSA-168330", "R-HSA-983170", "R-HSA-381070", "R-CFA-3371453", "R-DDI-3371497", "R-HSA-8874177", "R-SCE-9837999", "R-HSA-3371571", "R-CFA-6798695", "R-SPO-72163", "R-RNO-9833482", "R-CEL-3371453", "R-HSA-6798695", "R-BTA-9909505", "R-DRE-3371568", "R-HSA-3000484", "R-BTA-3371568", "R-HSA-8856828", "R-SPO-3371571", "R-CEL-6798695", "R-DME-3371497", "R-BTA-6798695", "R-MMU-9833482", "R-HSA-3371453", "R-DME-3371571", "R-DRE-6798695", "R-HSA-1268020", "R-DDI-9841251", "R-HSA-6803157", "R-BTA-9837999", "R-CFA-9833482", "R-HSA-9613354", "R-SSC-3371571", "R-BTA-6799198", "R-BTA-8876725", "R-RNO-432722", "R-HSA-9865881", "R-DME-3371453", "R-CEL-9837999", "R-BTA-3371453", "R-BTA-450408", "R-MMU-6799198", "R-HSA-9918432", "R-RNO-432720", "R-GGA-9909505", "R-BTA-3371571", "R-HSA-8950505", "R-BTA-888590", "R-SCE-9865881", "R-HSA-6785807", "R-DDI-6799198", "R-HSA-8949613", "R-HSA-381033", "R-SSC-9841251", "R-DME-9841251", "R-HSA-9613829", "R-BTA-3371497", "R-MMU-6798695", "R-DME-450408", "R-SPO-6798695", "R-RNO-983170", "R-RNO-3371453", "R-HSA-8876725", "R-MMU-432722", "R-RNO-9841251", "R-HSA-1221632", "R-DRE-9833482", "R-HSA-9909505", 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Vesicle Biogenesis", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DDI-8876725:r:Protein methylation", "R-HSA-447041:r:CHL1 interactions", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-3371568:r:Attenuation phase", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-3371571:r:HSF1-dependent transactivation", "R-CFA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-9833482:r:PKR-mediated signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SCE-8876725:r:Protein methylation", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", 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GTPase cycle", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-209968:r:Thyroxine biosynthesis"], "type": "Domain"}, "IPR013131": {"description": "Mannitol dehydrogenase, N-terminal", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Mannitol_DH_N", "pathway_ids": ["PWY-6531"], "pathways": ["PWY-6531:t:mannitol cycle"], "type": "Domain"}, "IPR013132": {"description": "PseI/NeuA/B-like", "go_ids": ["GO:0016051"], "go_terms": ["GO:0016051:carbohydrate biosynthetic process:P"], "name": "PseI/NeuA/B-like_N", "pathway_ids": ["R-MMU-4085001", "R-HSA-4085001", "R-DME-4085001"], "pathways": ["R-MMU-4085001:r:Sialic acid metabolism", "R-HSA-4085001:r:Sialic acid metabolism", "R-DME-4085001:r:Sialic acid metabolism"], "type": "Domain"}, "IPR013134": {"description": "RAD50, zinc hook", "go_ids": [], "go_terms": [], "name": "Zn_hook_RAD50", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5693565", "R-SCE-2559586", "R-MMU-6804756", "R-DDI-2559586", "R-RNO-5685939", "R-HSA-5693565", "R-MMU-5693616", "R-RNO-5693548", "R-DME-5693565", "R-HSA-2559586", "R-MMU-5685938", "R-DDI-5693565", "R-MMU-5693565", "R-MMU-69473", "R-DME-5685939", "R-SCE-5693565", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-5685938", "R-CEL-5685939", "R-HSA-912446", "R-MMU-5685939", "R-RNO-6804756", "R-SCE-5693548", "R-MMU-5693568", "R-DDI-5693607", "R-MMU-5693579", "R-SPO-5685939", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-DME-5693607", "R-DDI-5693616", "R-CEL-5693548", "R-RNO-2559586", "R-MMU-5693548", "R-RNO-5693579", "R-MMU-2559586", "R-HSA-69473", "R-RNO-5693607", "R-MMU-5685942", "R-HSA-9709603", "R-RNO-5693571", "R-HSA-5685939", "R-SPO-5693565", "R-RNO-69473", "R-RNO-5685942", "R-HSA-5693571", "R-HSA-6804756", "R-SPO-2559586", "R-HSA-9704331", "R-RNO-5693568", "R-DME-2559586", "R-DDI-5693548", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-HSA-5693579", "R-SPO-5693548", "R-MMU-5693571", "R-DME-5693548"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DME-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CEL-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DME-5693607:r:Processing of DNA double-strand break ends", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-CEL-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks"], "type": "Domain"}, "IPR013135": {"description": "Vitelline membrane cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "Vitelline_membr_Cys-rich-dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013136": {"description": "WSTF/Acf1/Cbp146", "go_ids": [], "go_terms": [], "name": "WSTF_Acf1_Cbp146", "pathway_ids": ["R-MMU-5693565", "R-DRE-5693565", "R-MMU-5250924", "R-HSA-5693565", "R-DRE-5250924", "R-HSA-5250924"], "pathways": ["R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression"], "type": "Domain"}, "IPR013137": {"description": "Zinc finger, TFIIB-type", "go_ids": [], "go_terms": [], "name": "Znf_TFIIB", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-RNO-6807505", "R-MMU-75953", "R-HSA-6807505", "R-SCE-75953", "R-RNO-674695", "R-DME-76042", "R-RNO-73779", "R-BTA-76042", "R-SPO-6807505", "R-DDI-73776", "R-BTA-76071", "R-MMU-76066", "R-RNO-73776", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-CEL-75953", "R-MMU-76061", "R-HSA-76061", "R-DME-75953", "R-HSA-749476", "R-MMU-73779", "R-CEL-73776", "R-MMU-76042", "R-SPO-75953", "R-SCE-76061", "R-CEL-6807505", "R-BTA-75953", "R-DME-674695", "R-DDI-73779", "R-RNO-76042", "R-SPO-76066", "R-DRE-76071", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-CEL-674695", "R-HSA-167161", "R-DME-6807505", "R-SCE-674695", "R-SPO-73779", "R-BTA-73776", "R-SPO-73776", "R-RNO-75953", "R-SCE-73776", "R-SCE-76066", "R-HSA-76066", "R-SPO-76061", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-MMU-73776", "R-DDI-76042", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-HSA-76071", "R-RNO-76071", "R-MMU-76071", "R-BTA-674695", "R-HSA-674695", "R-HSA-76042", "R-DDI-75953", "R-BTA-6807505", "R-CEL-76042", "R-HSA-73779"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DRE-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR013144": {"description": "CRA domain", "go_ids": [], "go_terms": [], "name": "CRA_dom", "pathway_ids": ["R-DRE-9861718", "R-DDI-9861718", "R-MMU-9861718", "R-BTA-9861718", "R-DRE-5673001", "R-DME-9861718", "R-HSA-373760", "R-HSA-9861718", "R-GGA-9861718", "R-HSA-5673001", "R-MMU-8851805", "R-DME-373760", "R-HSA-8851805", "R-MMU-5673001", "R-RNO-9861718", "R-MMU-373760", "R-DRE-8851805"], "pathways": ["R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-GGA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-MMU-8851805:r:MET activates RAS signaling", "R-DME-373760:r:L1CAM interactions", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-MMU-373760:r:L1CAM interactions", "R-DRE-8851805:r:MET activates RAS signaling"], "type": "Domain"}, "IPR013146": {"description": "LEM-like domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "LEM-like_dom", "pathway_ids": ["R-HSA-9013423", "R-HSA-9013405", "R-HSA-9013149", "R-HSA-9013409", "R-HSA-8980692", "R-HSA-4419969", "R-HSA-2980766", "R-HSA-9035034", "R-HSA-9013148", "R-HSA-2995383", "R-HSA-9013408", "R-HSA-9013106", "R-HSA-9013404"], "pathways": ["R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle"], "type": "Domain"}, "IPR013147": {"description": "CD47-like, transmembrane", "go_ids": [], "go_terms": [], "name": "CD47-like_TM", "pathway_ids": ["R-HSA-6798695", "R-SSC-6798695", "R-HSA-216083", "R-RNO-216083", "R-RNO-202733", "R-SSC-391160", "R-MMU-202733", "R-MMU-391160", "R-SSC-216083", "R-MMU-216083", "R-MMU-6798695", "R-RNO-391160", "R-SSC-202733", "R-HSA-202733", "R-RNO-6798695", "R-HSA-391160"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-SSC-216083:r:Integrin cell surface interactions", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-391160:r:Signal regulatory protein family interactions"], "type": "Domain"}, "IPR013148": {"description": "Glycosyl hydrolase family 32, N-terminal", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_32_N", "pathway_ids": ["PWY-8314"], "pathways": ["PWY-8314:t:inulin degradation"], "type": "Domain"}, "IPR013149": {"description": "Alcohol dehydrogenase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "ADH-like_C", "pathway_ids": ["R-GGA-5365859", "R-GGA-71384", "R-HSA-9029558", "R-HSA-2142700", "R-RNO-5661270", "R-HSA-2142691", "R-DDI-71384", "R-RNO-77346", "R-CEL-5365859", "R-MMU-2161541", "R-DRE-77346", "R-RNO-2161541", "R-DME-2161541", "R-HSA-9918487", "R-DDI-2161541", "R-MTU-9635470", "R-DME-5365859", "R-HSA-2161541", "R-HSA-199220", "R-HSA-6803205", "R-SCE-71384", "R-HSA-77346", "R-CEL-71384", "R-SPO-5661270", "R-HSA-5661270", "R-CEL-2161541", "R-MMU-77346", "R-SCE-5652227", "R-BTA-71384", "R-DME-71384", "R-MMU-5661270", "R-SPO-77346", "R-HSA-9918481", "R-CEL-77346", "R-MMU-5652227", "R-DME-77346", "R-SPO-5365859", "R-SCE-5365859", "R-HSA-163765", "R-HSA-2162123", "R-SPO-5652227", "R-DDI-5365859", "R-GGA-2161541", "R-RNO-5365859", "R-SPO-2161541", "R-BTA-5652227", "R-SCE-5661270", "R-RNO-5652227", "R-HSA-5365859", "R-RNO-71384", "R-DDI-77346", "R-HSA-71384", "R-SPO-71384", "R-MMU-5365859", "R-BTA-5661270", "R-XTR-77346", "R-HSA-75105", "R-HSA-5652227", "R-HSA-2426168", "R-SCE-2161541", "R-MMU-71384"], "pathways": ["R-GGA-5365859:r:RA biosynthesis pathway", "R-GGA-71384:r:Ethanol oxidation", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DDI-71384:r:Ethanol oxidation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-5365859:r:RA biosynthesis pathway", "R-MMU-2161541:r:Abacavir metabolism", "R-DRE-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-2161541:r:Abacavir metabolism", "R-DME-2161541:r:Abacavir metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-DDI-2161541:r:Abacavir metabolism", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-DME-5365859:r:RA biosynthesis pathway", "R-HSA-2161541:r:Abacavir metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-SCE-71384:r:Ethanol oxidation", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-71384:r:Ethanol oxidation", "R-SPO-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-CEL-2161541:r:Abacavir metabolism", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SCE-5652227:r:Fructose biosynthesis", "R-BTA-71384:r:Ethanol oxidation", "R-DME-71384:r:Ethanol oxidation", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-SPO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-5652227:r:Fructose biosynthesis", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SPO-5365859:r:RA biosynthesis pathway", "R-SCE-5365859:r:RA biosynthesis pathway", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-SPO-5652227:r:Fructose biosynthesis", "R-DDI-5365859:r:RA biosynthesis pathway", "R-GGA-2161541:r:Abacavir metabolism", "R-RNO-5365859:r:RA biosynthesis pathway", "R-SPO-2161541:r:Abacavir metabolism", "R-BTA-5652227:r:Fructose biosynthesis", "R-SCE-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-5652227:r:Fructose biosynthesis", "R-HSA-5365859:r:RA biosynthesis pathway", "R-RNO-71384:r:Ethanol oxidation", "R-DDI-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-71384:r:Ethanol oxidation", "R-SPO-71384:r:Ethanol oxidation", "R-MMU-5365859:r:RA biosynthesis pathway", "R-BTA-5661270:r:Formation of xylulose-5-phosphate", "R-XTR-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-5652227:r:Fructose biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SCE-2161541:r:Abacavir metabolism", "R-MMU-71384:r:Ethanol oxidation"], "type": "Domain"}, "IPR013150": {"description": "Transcription factor TFIIB, cyclin-like domain", "go_ids": ["GO:0017025"], "go_terms": ["GO:0017025:TBP-class protein binding:F"], "name": "TFIIB_cyclin", "pathway_ids": ["R-CEL-73779", "R-SCE-76066", "R-SPO-674695", "R-RNO-6807505", "R-MMU-75953", "R-RNO-674695", "R-SCE-75953", "R-HSA-6807505", "R-DME-76042", "R-RNO-73779", "R-HSA-76066", "R-SPO-6807505", "R-DDI-73776", "R-SPO-76061", "R-DME-73779", "R-MMU-76066", "R-RNO-73776", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-SCE-6807505", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-CEL-75953", "R-MMU-76061", "R-HSA-76061", "R-MMU-73776", "R-DDI-76042", "R-DME-75953", "R-HSA-749476", "R-MMU-73779", "R-CEL-73776", "R-HSA-167172", "R-MMU-76042", "R-SPO-75953", "R-SCE-76061", "R-SCE-73779", "R-CEL-6807505", "R-DME-674695", "R-DDI-73779", "R-RNO-76042", "R-SPO-76066", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-CEL-674695", "R-HSA-167161", "R-DME-6807505", "R-SCE-674695", "R-SPO-73779", "R-HSA-76042", "R-HSA-674695", "R-DDI-75953", "R-SPO-73776", "R-CEL-76042", "R-RNO-75953", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR013151": {"description": "Immunoglobulin-like beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Immunoglobulin_dom", "pathway_ids": ["R-RNO-9013026", "R-MMU-8856828", "R-HSA-9669921", "R-HSA-9702624", "R-MMU-6811558", "R-HSA-9669936", "R-MMU-9014843", "R-DRE-190372", "R-MMU-933542", "R-DME-3000178", "R-MMU-202430", "R-MMU-202733", "R-DRE-5654228", "R-BTA-163125", "R-HSA-9702577", "R-DME-5654727", "R-CEL-428542", "R-GGA-5673001", "R-HSA-983695", "R-DME-109704", "R-HSA-9702509", "R-RNO-190374", "R-DME-190377", "R-HSA-163125", "R-DME-216083", "R-MMU-5654219", "R-HSA-180534", "R-RNO-388844", "R-DME-5654687", "R-MMU-194306", "R-HSA-9702581", "R-HSA-9680350", "R-HSA-9702620", "R-MMU-5654227", "R-RNO-216083", "R-HSA-1059683", "R-DME-1971475", "R-HSA-202433", "R-RNO-1257604", "R-RNO-8980692", "R-DRE-109704", "R-MMU-9034793", "R-HSA-9669924", "R-HSA-388844", "R-MMU-5654704", "R-RNO-8856828", "R-GGA-1433557", "R-CFA-1433557", "R-DME-5654219", "R-HSA-9706369", "R-RNO-2132295", "R-HSA-9603505", "R-HSA-5654726", "R-DME-5654719", "R-HSA-109704", "R-HSA-167590", "R-HSA-9034864", "R-MMU-1257604", "R-HSA-110056", "R-CEL-9749641", "R-HSA-9669934", "R-RNO-5654689", "R-MMU-190371", "R-HSA-8853336", "R-MMU-2029481", "R-RNO-9013423", "R-HSA-9034013", "R-DME-5654712", "R-DRE-1257604", "R-HSA-8856825", "R-HSA-9854909", "R-HSA-9680187", "R-RNO-389948", "R-MMU-5654687", "R-HSA-9856649", "R-DRE-4420097", "R-GGA-388844", "R-HSA-9702518", "R-MMU-9856649", "R-HSA-6798695", "R-CFA-9856649", "R-MMU-1433559", "R-RNO-9020702", "R-HSA-8856828", "R-MMU-9012546", "R-HSA-112411", "R-HSA-9669929", "R-BTA-6798695", "R-HSA-2029481", "R-HSA-9670439", "R-RNO-190370", "R-HSA-5654693", "R-DRE-5673001", "R-CFA-1257604", "R-MMU-445989", "R-RNO-202427", "R-MMU-9706374", "R-CFA-5673001", "R-HSA-9007892", "R-MMU-2029485", "R-DME-190372", "R-RNO-9013408", "R-RNO-9013404", "R-RNO-5673001", "R-DME-5654227", "R-HSA-447043", "R-CEL-216083", "R-HSA-9706374", "R-MMU-1433557", "R-DME-5654704", "R-HSA-2172127", "R-HSA-9034793", "R-HSA-2029482", "R-HSA-9673768", "R-RNO-163125", "R-HSA-194306", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1462054", "R-HSA-5218921", "R-MMU-198933", "R-DRE-5654704", "R-MMU-202427", "R-MMU-6798695", "R-HSA-1257604", "R-MMU-9034013", "R-MMU-416700", "R-RNO-194306", "R-MMU-5654710", "R-RNO-432142", "R-HSA-416550", "R-HSA-9702605", "R-DME-419037", "R-DME-5654700", "R-HSA-5654687", "R-MMU-112411", "R-DME-5654693", "R-RNO-1059683", "R-RNO-109704", "R-HSA-375165", "R-RNO-114608", "R-HSA-9702614", "R-HSA-416700", "R-MMU-190373", "R-DME-190374", "R-RNO-110056", "R-MMU-110056", "R-MMU-5683826", "R-DME-2024096", "R-GGA-1257604", "R-MMU-389948", "R-HSA-1839122", "R-MMU-9603381", "R-HSA-9645135", "R-RNO-8856825", "R-HSA-216083", "R-HSA-1462054", "R-RNO-9034793", "R-CEL-210991", "R-DME-5654689", "R-HSA-1236978", "R-RNO-5683826", "R-MMU-2029482", "R-HSA-9706377", "R-MMU-1059683", "R-RNO-9007892", "R-DME-190373", "R-RNO-202430", "R-MMU-1236978", "R-HSA-389948", "R-HSA-202424", "R-HSA-9702600", "R-RNO-449836", "R-HSA-9607240", "R-HSA-9020702", "R-HSA-9918485", "R-MMU-9020702", "R-RNO-202433", "R-HSA-9702596", "R-DME-5654732", "R-HSA-9669935", "R-HSA-202427", "R-HSA-2979096", "R-MMU-5654706", "R-RNO-6811558", "R-RNO-210990", "R-DRE-6811558", "R-HSA-9603381", "R-HSA-9702632", "R-HSA-9616222", "R-MMU-5673001", "R-MMU-449836", "R-HSA-173107", "R-HSA-9669917", "R-DME-190370", "R-MMU-9007892", "R-HSA-5654689", "R-RNO-445144", "R-HSA-1839120", "R-CFA-983695", "R-HSA-9702590", "R-MMU-190372", "R-MMU-5690714", "R-HSA-447041", "R-MMU-9013423", "R-HSA-1433559", "R-HSA-9703009", "R-RNO-5654688", "R-DME-5654695", "R-DME-1257604", "R-DRE-190371", "R-HSA-9793380", "R-HSA-445144", "R-MMU-2730905", "R-HSA-9664323", "R-RNO-6798695", "R-DME-5673001", "R-HSA-416572", "R-HSA-445095", "R-RNO-9035034", "R-MMU-190374", "R-GGA-9856649", "R-HSA-2029485", "R-HSA-373760", "R-MMU-388844", "R-HSA-190374", "R-MMU-190370", "R-CFA-6811558", "R-HSA-9669926", "R-HSA-9702636", "R-DME-5654699", "R-MMU-202424", "R-DRE-195399", "R-DRE-1307965", "R-MMU-109704", "R-HSA-2129379", "R-DRE-5654227", "R-RNO-9603381", "R-RNO-447043", "R-MMU-9706369", "R-HSA-5690714", "R-HSA-190370", "R-MMU-447043", "R-DME-1474228", "R-MMU-5654726", "R-HSA-9669914", "R-HSA-5654219", "R-DRE-5654732", "R-DME-190375", "R-HSA-877300", "R-MMU-5654693", "R-MMU-5654689", "R-HSA-9856530", "R-HSA-9702569", "R-RNO-5654219", "R-DME-5654706", "R-MMU-9013149", "R-HSA-202733", "R-DME-5654733", "R-HSA-9927426", "R-CEL-433692", "R-HSA-5654688", "R-MMU-163125", "R-MMU-9607240", "R-RNO-5654726", "R-DME-375165", "R-HSA-9758919", "R-HSA-2168880", "R-DME-190371", "R-DRE-194306", "R-RNO-9013149", "R-DRE-5654712", "R-DRE-5218921", "R-HSA-9927418", "R-MMU-2871796", "R-HSA-4420097", "R-RNO-190373", "R-RNO-202733", "R-DME-1307965", "R-RNO-202424", "R-DRE-5654733", "R-MMU-5654732", "R-RNO-9034013", "R-HSA-202430", "R-HSA-5655302", "R-HSA-6783783", "R-DRE-5654720", "R-RNO-5654693", "R-DRE-5654706", "R-RNO-198933", "R-HSA-2219530", "R-MMU-445144", "R-HSA-6785807", "R-DME-5654688", "R-GGA-2132286", "R-MMU-195399", "R-DRE-5654710", "R-DME-5654710", "R-DME-445144", "R-HSA-9703648", "R-MMU-2871837", "R-HSA-9702998", "R-HSA-198933", "R-MMU-1462054", "R-MMU-5654688", "R-RNO-4420097", "R-GGA-2132263", "R-HSA-8853884", "R-HSA-9669933", "R-HSA-449836", "R-HSA-2122948", "R-MMU-8856825", "R-DME-5654720", "R-HSA-9034015", "R-CFA-5690714", "R-DME-6811558", "R-CEL-1474228", "R-BTA-114608", "R-CFA-1433559", "R-DME-9913351", "R-HSA-8866910", "R-GGA-6811558", "R-RNO-5654687", "R-RNO-9013106", "R-HSA-195399", "R-DME-5654221", "R-RNO-112411", "R-MMU-202433", "R-HSA-1566977", "R-DME-5654228", "R-HSA-190373", "R-MMU-879415", "R-DRE-190322", "R-HSA-9679191", "R-MMU-983695", "R-MMU-2454202", "R-HSA-1433557", "R-RNO-195399", "R-GGA-1433559", "R-RNO-5218921", "R-DME-190322", "R-DME-2022928", "R-MMU-2871809", "R-DME-3000171", "R-DRE-5654719", "R-DME-5654726"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-HSA-9702624:r:sorafenib-resistant FLT3 mutants", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-MMU-9014843:r:Interleukin-33 signaling", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-DME-3000178:r:ECM proteoglycans", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9702577:r:semaxanib-resistant FLT3 mutants", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-CEL-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-109704:r:PI3K Cascade", "R-HSA-9702509:r:FLT3 mutants bind TKIs", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-9702581:r:crenolanib-resistant FLT3 mutants", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-9702620:r:quizartinib-resistant FLT3 mutants", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-202433:r:Generation of second messenger molecules", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-DRE-109704:r:PI3K Cascade", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9706369:r:Negative regulation of FLT3", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-109704:r:PI3K Cascade", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-CEL-9749641:r:Aspirin ADME", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-2029481:r:FCGR activation", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-6798695:r:Neutrophil degranulation", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-1433559:r:Regulation of KIT signaling", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9012546:r:Interleukin-18 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2029481:r:FCGR activation", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9007892:r:Interleukin-38 signaling", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-447043:r:Neurofascin interactions", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-2172127:r:DAP12 interactions", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1462054:r:Alpha-defensins", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-MMU-416700:r:Other semaphorin interactions", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-432142:r:Platelet sensitization by LDL", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-9702605:r:pexidartinib-resistant FLT3 mutants", "R-DME-419037:r:NCAM1 interactions", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-109704:r:PI3K Cascade", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-114608:r:Platelet degranulation", "R-HSA-9702614:r:ponatinib-resistant FLT3 mutants", "R-HSA-416700:r:Other semaphorin interactions", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-MMU-5683826:r:Surfactant metabolism", "R-DME-2024096:r:HS-GAG degradation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-389948:r:Co-inhibition by PD-1", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-9645135:r:STAT5 Activation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-1462054:r:Alpha-defensins", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-CEL-210991:r:Basigin interactions", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-9007892:r:Interleukin-38 signaling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9702600:r:midostaurin-resistant FLT3 mutants", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-202433:r:Generation of second messenger molecules", "R-HSA-9702596:r:lestaurtinib-resistant FLT3 mutants", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210990:r:PECAM1 interactions", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-9702632:r:sunitinib-resistant FLT3 mutants", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-MMU-9007892:r:Interleukin-38 signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-RNO-445144:r:Signal transduction by L1", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-CFA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9702590:r:gilteritinib-resistant FLT3 mutants", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-447041:r:CHL1 interactions", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-9703009:r:tamatinib-resistant FLT3 mutants", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-HSA-9702636:r:tandutinib-resistant FLT3 mutants", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-202424:r:Downstream TCR signaling", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-MMU-109704:r:PI3K Cascade", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-DRE-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-447043:r:Neurofascin interactions", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-MMU-447043:r:Neurofascin interactions", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9702569:r:KW2449-resistant FLT3 mutants", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-CEL-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-RNO-202424:r:Downstream TCR signaling", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-6783783:r:Interleukin-10 signaling", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-GGA-2132286:r:Classical antibody-mediated complement activation", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DRE-5654710:r:PI-3K cascade:FGFR3", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9702998:r:linifanib-resistant FLT3 mutants", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-1462054:r:Alpha-defensins", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9669933:r:Signaling by kinase domain mutants of KIT", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-CFA-5690714:r:CD22 mediated BCR regulation", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-BTA-114608:r:Platelet degranulation", "R-CFA-1433559:r:Regulation of KIT signaling", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-MMU-202433:r:Generation of second messenger molecules", "R-HSA-1566977:r:Fibronectin matrix formation", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-GGA-1433559:r:Regulation of KIT signaling", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-DME-2022928:r:HS-GAG biosynthesis", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-5654726:r:Negative regulation of FGFR1 signaling"], "type": "Domain"}, "IPR013153": {"description": "PrkA, AAA domain", "go_ids": [], "go_terms": [], "name": "Prk_AAA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013154": {"description": "Alcohol dehydrogenase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "ADH-like_N", "pathway_ids": ["R-GGA-5365859", "R-GGA-71384", "R-DDI-71384", "R-HSA-6798695", "R-RNO-5661270", "R-RNO-77346", "R-DDI-75105", "R-CEL-5365859", "R-MMU-2161541", "R-DRE-77346", "R-RNO-2161541", "R-DME-2161541", "R-DDI-2161541", "R-MTU-9635470", "R-DME-5365859", "R-HSA-2161541", "R-HSA-6803205", "R-SCE-71384", "R-HSA-77346", "R-CEL-71384", "R-SPO-5661270", "R-HSA-5661270", "R-CEL-2161541", "R-MMU-77346", "R-SCE-5652227", "R-BTA-71384", "R-DME-71384", "R-DRE-6798695", "R-MMU-5661270", "R-DDI-199220", "R-CEL-77346", "R-MMU-5652227", "R-DME-77346", "R-SPO-5365859", "R-SCE-5365859", "R-SPO-5652227", "R-DDI-5365859", "R-GGA-2161541", "R-RNO-5365859", "R-SPO-2161541", "R-BTA-5652227", "R-SCE-5661270", "R-RNO-5652227", "R-HSA-5365859", "R-RNO-71384", "R-DDI-77346", "R-HSA-71384", "R-SPO-71384", "R-MMU-5365859", "R-BTA-5661270", "R-XTR-77346", "R-MMU-6798695", "R-HSA-5652227", "R-RNO-6798695", "R-SCE-2161541", "R-MMU-71384"], "pathways": ["R-GGA-5365859:r:RA biosynthesis pathway", "R-GGA-71384:r:Ethanol oxidation", "R-DDI-71384:r:Ethanol oxidation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-5365859:r:RA biosynthesis pathway", "R-MMU-2161541:r:Abacavir metabolism", "R-DRE-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-2161541:r:Abacavir metabolism", "R-DME-2161541:r:Abacavir metabolism", "R-DDI-2161541:r:Abacavir metabolism", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-DME-5365859:r:RA biosynthesis pathway", "R-HSA-2161541:r:Abacavir metabolism", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-SCE-71384:r:Ethanol oxidation", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-71384:r:Ethanol oxidation", "R-SPO-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-CEL-2161541:r:Abacavir metabolism", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SCE-5652227:r:Fructose biosynthesis", "R-BTA-71384:r:Ethanol oxidation", "R-DME-71384:r:Ethanol oxidation", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-5652227:r:Fructose biosynthesis", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SPO-5365859:r:RA biosynthesis pathway", "R-SCE-5365859:r:RA biosynthesis pathway", "R-SPO-5652227:r:Fructose biosynthesis", "R-DDI-5365859:r:RA biosynthesis pathway", "R-GGA-2161541:r:Abacavir metabolism", "R-RNO-5365859:r:RA biosynthesis pathway", "R-SPO-2161541:r:Abacavir metabolism", "R-BTA-5652227:r:Fructose biosynthesis", "R-SCE-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-5652227:r:Fructose biosynthesis", "R-HSA-5365859:r:RA biosynthesis pathway", "R-RNO-71384:r:Ethanol oxidation", "R-DDI-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-71384:r:Ethanol oxidation", "R-SPO-71384:r:Ethanol oxidation", "R-MMU-5365859:r:RA biosynthesis pathway", "R-BTA-5661270:r:Formation of xylulose-5-phosphate", "R-XTR-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5652227:r:Fructose biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-SCE-2161541:r:Abacavir metabolism", "R-MMU-71384:r:Ethanol oxidation"], "type": "Domain"}, "IPR013155": {"description": "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding", "go_ids": ["GO:0004812", "GO:0006418"], "go_terms": ["GO:0004812:aminoacyl-tRNA ligase activity:F", "GO:0006418:tRNA aminoacylation for protein translation:P"], "name": "M/V/L/I-tRNA-synth_anticd-bd", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9837999", "R-DDI-9856649", "R-MMU-9837999", "R-HSA-2408522", "R-SPO-9837999", "R-GGA-9837999", "R-SCE-9837999", "R-HSA-9856649", "R-HSA-9837999", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-GGA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR013156": {"description": "Pseudin antimicrobial peptide", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "Antimicrobial_19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013157": {"description": "Aurein antibiotic peptide family", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "Aurein_antimicrobial_peptide", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013158": {"description": "Activation-induced cytidine deaminase AID", "go_ids": ["GO:0008270", "GO:0016814"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0016814:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines:F"], "name": "AID", "pathway_ids": ["R-HSA-9821002"], "pathways": ["R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)"], "type": "Domain"}, "IPR013159": {"description": "Chromosomal replication initiator, DnaA C-terminal", "go_ids": ["GO:0005524", "GO:0006270", "GO:0006275", "GO:0043565"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006270:DNA replication initiation:P", "GO:0006275:regulation of DNA replication:P", "GO:0043565:sequence-specific DNA binding:F"], "name": "DnaA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013161": {"description": "Benzylsuccinate synthase gamma subunit", "go_ids": [], "go_terms": [], "name": "BssC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013162": {"description": "CD80-like, immunoglobulin C2-set", "go_ids": [], "go_terms": [], "name": "CD80_C2-set", "pathway_ids": ["R-CEL-373753", "R-DME-420597", "R-HSA-9013405", "R-HSA-6798695", "R-MMU-389359", "R-HSA-879415", "R-RNO-9013026", "R-MMU-210991", "R-MMU-9013106", "R-MMU-6811558", "R-MMU-9013408", "R-RNO-373753", "R-RNO-9013149", "R-MMU-9013404", "R-MMU-933542", "R-MMU-389357", "R-MMU-389356", "R-HSA-418990", "R-MMU-445989", "R-HSA-389359", "R-MMU-9929491", "R-DRE-418990", "R-MMU-9929356", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-MMU-193634", "R-HSA-6783783", "R-HSA-210991", "R-HSA-9701898", "R-HSA-9931295", "R-HSA-373753", "R-MMU-9035034", "R-HSA-9931269", "R-HSA-9929491", "R-BTA-198933", "R-HSA-983695", "R-RNO-198933", "R-HSA-2172127", "R-HSA-2219530", "R-RNO-193634", "R-MMU-5690714", "R-GGA-2132286", "R-DME-373753", "R-HSA-6811558", "R-HSA-9013404", "R-MMU-373753", "R-HSA-9013149", "R-HSA-389356", "R-MMU-9013423", "R-MMU-198933", "R-HSA-8980692", "R-RNO-879415", "R-MMU-420597", "R-MMU-9931269", "R-HSA-389357", "R-HSA-9013026", "R-HSA-198933", "R-DRE-420597", "R-RNO-445989", "R-HSA-1257604", "R-RNO-933542", "R-HSA-445989", "R-GGA-2132263", "R-RNO-420597", "R-RNO-9035034", "R-MMU-8980692", "R-HSA-933542", "R-RNO-8980692", "R-RNO-418990", "R-HSA-9619665", "R-HSA-9013106", "R-HSA-373760", "R-HSA-9013423", "R-MMU-9931295", "R-HSA-9035034", "R-RNO-9013106", "R-HSA-420597", "R-HSA-389513", "R-MMU-389948", "R-RNO-210991", "R-XTR-418990", "R-MMU-879415", "R-HSA-5690714", "R-MMU-983695", "R-MMU-1257604", "R-DME-418990", "R-MMU-418990", "R-MMU-389513", "R-RNO-9013423", "R-HSA-193634", "R-HSA-9929356", "R-MMU-9927354", "R-MMU-9013026", "R-HSA-9909620", "R-MMU-9013149", "R-HSA-389948"], "pathways": ["R-CEL-373753:r:Nephrin family interactions", "R-DME-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-210991:r:Basigin interactions", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-373753:r:Nephrin family interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-389356:r:Co-stimulation by CD28", "R-HSA-418990:r:Adherens junctions interactions", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DRE-418990:r:Adherens junctions interactions", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", 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inhibition (RHOA activation)", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-GGA-2132286:r:Classical antibody-mediated complement activation", "R-DME-373753:r:Nephrin family interactions", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-373753:r:Nephrin family interactions", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-389356:r:Co-stimulation by CD28", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-420597:r:Nectin/Necl trans heterodimerization", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-RNO-420597:r:Nectin/Necl trans heterodimerization", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-418990:r:Adherens junctions interactions", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-420597:r:Nectin/Necl trans 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"Domain"}, "IPR013164": {"description": "Cadherin, N-terminal", "go_ids": [], "go_terms": [], "name": "Cadherin_N", "pathway_ids": ["R-HSA-9013026", "R-HSA-114608", "R-HSA-9830364", "R-HSA-8980692"], "pathways": ["R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-8980692:r:RHOA GTPase cycle"], "type": "Domain"}, "IPR013166": {"description": "Citrate lyase ligase, C-terminal", "go_ids": ["GO:0008771"], "go_terms": ["GO:0008771:[citrate (pro-3S)-lyase] ligase activity:F"], "name": "Citrate_lyase_ligase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013167": {"description": "COG4 transport protein, middle alpha-helical bundle", "go_ids": [], "go_terms": [], "name": "COG4_M", "pathway_ids": ["R-DRE-6811438", "R-BTA-6807878", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-DRE-6807878", "R-DME-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-BTA-6811440", "R-BTA-6811438", 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"R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Family"}, "IPR013180": {"description": "Beta-catenin-like protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "CTNNBL1_N", "pathway_ids": ["R-HSA-72163", "R-RNO-72163", "R-SPO-72163", "R-HSA-9918481", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR013181": {"description": "Protein of unknown function DUF1719", "go_ids": [], "go_terms": [], "name": "DUF1719", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013182": {"description": "Domain of unknown function DUF1720", "go_ids": [], "go_terms": [], "name": "DUF1720", "pathway_ids": ["R-SPO-8856825"], "pathways": ["R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis"], "type": "Domain"}, "IPR013183": {"description": "DASH complex subunit Hsk3-like", "go_ids": [], "go_terms": [], "name": "Hsk3-like", "pathway_ids": ["R-RNO-162658", "R-MMU-162658", "R-HSA-162658"], "pathways": ["R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization"], "type": "Family"}, "IPR013184": {"description": "Lactococcus phage c2, E2", "go_ids": [], "go_terms": [], "name": "Lactococcus_phage_c2_E2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013185": {"description": "Translation elongation factor, KOW-like", "go_ids": [], "go_terms": [], "name": "Transl_elong_KOW-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013186": {"description": "Early nodulin 40", "go_ids": ["GO:0009877"], "go_terms": ["GO:0009877:nodulation:P"], "name": "ENOD40", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013187": {"description": "F-box associated beta-propeller, type 3", "go_ids": [], "go_terms": [], "name": "F-box-assoc_dom_typ3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013188": {"description": "Influenza matrix M1, C-terminal", "go_ids": ["GO:0003723", "GO:0005198"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005198:structural molecule activity:F"], "name": "Flu_matrix_M1_C", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168288", "R-HSA-168275", "R-HSA-168316", "R-HSA-168298", "R-HSA-168330", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-168298:r:Release", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Domain"}, "IPR013189": {"description": "Glycosyl hydrolase family 32, C-terminal", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_32_C", "pathway_ids": ["PWY-8314"], "pathways": ["PWY-8314:t:inulin degradation"], "type": "Domain"}, "IPR013190": {"description": "Glycosyl hydrolase family 98, C-terminal", "go_ids": [], "go_terms": [], "name": "GH98_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013191": {"description": "Glycosyl hydrolase family 98, central domain", "go_ids": [], "go_terms": [], "name": "GH98_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013192": {"description": "Hepatitis C virus, Non-structural 5a protein, domain 1a", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "HCV_NS5A_1a", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR013193": {"description": "Hepatitis C virus non-structural 5a, 1B domain", "go_ids": [], "go_terms": [], "name": "HCV_NS5a_1B_dom", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR013194": {"description": "Histone deacetylase interacting domain", "go_ids": [], "go_terms": [], "name": "HDAC_interact_dom", "pathway_ids": ["R-HSA-9022702", "R-MMU-8936459", "R-MMU-9824594", "R-HSA-9824594", "R-HSA-9022692", "R-MMU-3899300", "R-HSA-8936459", "R-HSA-427413", "R-HSA-983231", "R-CEL-9825892", "R-HSA-9022538", "R-CEL-9824594", "R-HSA-9615017", "R-MMU-9022692", "R-HSA-9707564", "R-HSA-400206", "R-HSA-9022699", "R-HSA-3899300", "R-MMU-9825892", "R-HSA-9825892", "R-HSA-9701898", "R-MMU-400206", "R-MMU-9707564"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9022538:r:Loss of MECP2 binding ability to 5mC-DNA", "R-CEL-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR013195": {"description": "Hepatitis B virus, capsid N-terminal", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural 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Polymerase III Transcription Initiation From Type 1 Promoter", "R-DRE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-DRE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR013198": {"description": "Global transcriptional regulator CodY, C-terminal", "go_ids": [], "go_terms": [], "name": "GTP_trans_reg_CodY_C", 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"R-DME-8939242", "R-CFA-8939242", "R-MMU-6798695", "R-MMU-9766229", "R-HSA-8939242", "R-RNO-6798695", "R-MMU-114608", "R-SSC-6798695", "R-HSA-2132295", "R-CFA-9768919", "R-BTA-1442490", "R-MMU-8939242", "R-CFA-2022090", "R-HSA-114608", "R-MMU-2132295", "R-HSA-2024096", "R-SSC-8939242", "R-SSC-1442490", "R-BTA-2132295", "R-CFA-211976", "R-HSA-1442490", "R-MMU-5683826", "R-DME-2024096", "R-RNO-2132295", "R-CFA-1592389", "R-RNO-1592389", "R-DME-2022090", "R-HSA-1592389", "R-RNO-5683826", "R-HSA-1236977", "R-RNO-1442490", "R-MMU-2022090", "R-DME-1474228", "R-HSA-1679131", "R-PFA-114608", "R-CFA-1679131", "R-CFA-8937144", "R-DME-1442490", "R-RNO-9766229", "R-DME-2132295", "R-BTA-5683826", "R-SSC-5683826", "R-MMU-1442490", "R-BTA-8939242", "R-DDI-2132295"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-1679131:r:Trafficking and processing of endosomal TLR", "R-CFA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-SSC-1679131:r:Trafficking and 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"R-SSC-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-114608:r:Platelet degranulation", "R-HSA-9694614:r:Attachment and Entry", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-CEL-5683826:r:Surfactant metabolism", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-5683826:r:Surfactant metabolism", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-DME-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-CFA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-CFA-9768919:r:NPAS4 regulates expression of target genes", "R-BTA-1442490:r:Collagen degradation", "R-MMU-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-CFA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-114608:r:Platelet degranulation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-2024096:r:HS-GAG degradation", "R-SSC-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-SSC-1442490:r:Collagen degradation", "R-BTA-2132295:r:MHC class II antigen presentation", "R-CFA-211976:r:Endogenous sterols", "R-HSA-1442490:r:Collagen degradation", "R-MMU-5683826:r:Surfactant metabolism", "R-DME-2024096:r:HS-GAG degradation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-5683826:r:Surfactant metabolism", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-RNO-1442490:r:Collagen degradation", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-PFA-114608:r:Platelet degranulation", "R-CFA-1679131:r:Trafficking and processing of endosomal TLR", "R-CFA-8937144:r:Aryl hydrocarbon receptor signalling", "R-DME-1442490:r:Collagen degradation", "R-RNO-9766229:r:Degradation of CDH1", "R-DME-2132295:r:MHC class II antigen presentation", "R-BTA-5683826:r:Surfactant metabolism", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-1442490:r:Collagen degradation", "R-BTA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-DDI-2132295:r:MHC class II antigen presentation"], "type": "Domain"}, "IPR013202": {"description": "Kinin peptide", "go_ids": [], "go_terms": [], "name": "Kinin_peptide", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013203": {"description": "Leader peptide, Arg-2/CPA1", "go_ids": [], "go_terms": [], "name": "Leader_Arg2_CPA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013204": {"description": "23S rRNA methylase leader peptide, bacilli", "go_ids": [], "go_terms": [], "name": "ErmC_bacilli", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013205": {"description": "Leader peptide, tryptophan-operon", "go_ids": [], "go_terms": [], "name": "Leader_Trp_op", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013206": {"description": "Leucophaea maderae tachykinin-related peptide", "go_ids": [], "go_terms": [], "name": "Lem_TRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013207": {"description": "LGFP", "go_ids": [], "go_terms": [], "name": "LGFP", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR013209": {"description": "Lipin/Ned1/Smp2 (LNS2)", "go_ids": [], "go_terms": [], "name": "LNS2", "pathway_ids": ["PWY-7782", "PWY-8053", "PWY-8052", "PWY-8051", "PWY-8055", "PWY-6453", "R-HSA-1483191", "R-SPO-75109", "R-HSA-4419969", "R-SCE-75109", "R-HSA-1483213", "R-SCE-1483213", "R-MMU-75109", "R-HSA-75109", "R-MMU-1483191", "R-SPO-1483213", "R-SPO-4419969", "R-SCE-1483191", "R-MMU-4419969", "R-SCE-4419969", "R-MMU-1483213", "R-HSA-9841922", "R-SPO-1483191"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-8053:t:anandamide biosynthesis II", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "R-HSA-1483191:r:Synthesis of PC", "R-SPO-75109:r:Triglyceride biosynthesis", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-75109:r:Triglyceride biosynthesis", "R-HSA-1483213:r:Synthesis of PE", "R-SCE-1483213:r:Synthesis of PE", "R-MMU-75109:r:Triglyceride biosynthesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-MMU-1483191:r:Synthesis of PC", "R-SPO-1483213:r:Synthesis of PE", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-1483191:r:Synthesis of PC", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-1483213:r:Synthesis of PE", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SPO-1483191:r:Synthesis of PC"], "type": "Domain"}, "IPR013210": {"description": "Leucine-rich repeat-containing N-terminal, plant-type", "go_ids": [], "go_terms": [], "name": "LRR_N_plant-typ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013211": {"description": "LVIVD", "go_ids": [], "go_terms": [], "name": "LVIVD", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR013212": {"description": "Mad3/Bub1 homology region 1", "go_ids": [], "go_terms": [], "name": "Mad3/Bub1_I", "pathway_ids": ["R-SPO-141430", "R-MMU-2500257", "R-HSA-176409", "R-MMU-176409", "R-MMU-141444", "R-HSA-2467813", "R-HSA-2500257", "R-MMU-2467813", "R-SCE-141430", "R-MMU-179409", "R-HSA-141444", "R-MMU-68877", "R-HSA-9648025", "R-HSA-174184", "R-SPO-179409", "R-DDI-179409", "R-HSA-141430", "R-MMU-174184", "R-DDI-176409", "R-DDI-174184", "R-HSA-68877", "R-MMU-141430", "R-DDI-141430", "R-HSA-5663220", "R-HSA-179409", "R-MMU-9648025", "R-MMU-5663220"], "pathways": ["R-SPO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SCE-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR013213": {"description": "Mastoparan", "go_ids": [], "go_terms": [], "name": "Mastoparan", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013214": {"description": "Mastoparan peptide", "go_ids": [], "go_terms": [], "name": "Mastoparan_peptide", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013215": {"description": "Cobalamin-independent methionine synthase MetE, N-terminal", "go_ids": ["GO:0003871", "GO:0008270", "GO:0008652"], "go_terms": ["GO:0003871:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity:F", "GO:0008270:zinc ion binding:F", "GO:0008652:amino acid biosynthetic process:P"], "name": "Cbl-indep_Met_Synth_N", "pathway_ids": ["PWY-702", "PWY-6936", "PWY-6151", "PWY-5041"], "pathways": ["PWY-702:t:L-methionine biosynthesis II", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-6151:t:S-adenosyl-L-methionine salvage I", "PWY-5041:t:S-adenosyl-L-methionine salvage II"], "type": "Domain"}, "IPR013216": {"description": "Methyltransferase type 11", "go_ids": ["GO:0008757"], "go_terms": ["GO:0008757:S-adenosylmethionine-dependent methyltransferase activity:F"], "name": "Methyltransf_11", "pathway_ids": ["R-HSA-6798695", "R-MMU-6791226", "R-SCE-6791226", "R-HSA-6782315", "R-HSA-6791226", "R-MMU-6799198", "R-HSA-6799198", "R-DRE-6799198", "R-DDI-6791226", "R-RNO-6799198", "R-SPO-6791226", "R-HSA-6790901"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DRE-6799198:r:Complex I biogenesis", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6799198:r:Complex I biogenesis", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR013217": {"description": "Methyltransferase type 12", "go_ids": [], "go_terms": [], "name": "Methyltransf_12", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-DDI-75105", "R-HSA-75105", "R-DDI-199220", "R-HSA-9918487", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR013218": {"description": "Kinetochore-associated protein Dsn1/Mis13", "go_ids": ["GO:0007059", "GO:0000444", "GO:0051301"], "go_terms": ["GO:0007059:chromosome segregation:P", "GO:0000444:MIS12/MIND type complex:C", "GO:0051301:cell division:P"], "name": "Dsn1/Mis13", "pathway_ids": ["R-HSA-6798695", "R-MMU-2500257", "R-SPO-6798695", "R-HSA-2500257", "R-MMU-141444", "R-HSA-2467813", "R-HSA-68877", "R-MMU-2467813", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-141444", "R-HSA-5663220", "R-MMU-68877", "R-MMU-9648025", "R-HSA-9648025", "R-MMU-5663220"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR013219": {"description": "Small ribosomal subunit protein mS33", "go_ids": [], "go_terms": [], "name": "Ribosomal_mS33", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-BTA-9937383", "R-MMU-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR013220": {"description": "E3 ubiquitin-protein ligase substrate receptor Mms22, budding yeast", "go_ids": ["GO:0006281", "GO:0035361", "GO:0031297", "GO:0005634", "GO:0006974"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0035361:Cul8-RING ubiquitin ligase complex:C", "GO:0031297:replication fork processing:P", "GO:0005634:nucleus:C", "GO:0006974:DNA damage response:P"], "name": "Mms22_budding_yeast", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013221": {"description": "Mur ligase, central", "go_ids": ["GO:0016881", "GO:0005524", "GO:0009058"], "go_terms": ["GO:0016881:acid-amino acid ligase activity:F", "GO:0005524:ATP binding:F", "GO:0009058:biosynthetic process:P"], "name": "Mur_ligase_cen", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013222": {"description": "Glycosyl hydrolase family 98, putative carbohydrate-binding module", "go_ids": [], "go_terms": [], "name": "Glyco_hyd_98_carb-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013223": {"description": "Ribonuclease B, N-terminal OB domain", "go_ids": [], "go_terms": [], "name": "RNase_B_OB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013225": {"description": "Transcriptional repressor PaaX-like, C-terminal", "go_ids": [], "go_terms": [], "name": "PaaX_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013226": {"description": "Pal1 cell morphology", "go_ids": [], "go_terms": [], "name": "Pal1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013228": {"description": "PE-PPE, C-terminal", "go_ids": [], "go_terms": [], "name": "PE-PPE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013229": {"description": "PEGA", "go_ids": [], "go_terms": [], "name": "PEGA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013230": {"description": "Peptidase M15A, C-terminal", "go_ids": [], "go_terms": [], "name": "Peptidase_M15A_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013231": {"description": "Periviscerokinin", "go_ids": [], "go_terms": [], "name": "Periviscerokinin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013232": {"description": "Bacteriophage T7, Gp1.1", "go_ids": [], "go_terms": [], "name": "Phage_T7_Gp1.1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013233": {"description": "Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1", "go_ids": ["GO:0005789", "GO:0006506"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0006506:GPI anchor biosynthetic process:P"], "name": "PIG-X/PBN1", "pathway_ids": ["R-HSA-162710", "R-RNO-162710", "R-MMU-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR013234": {"description": "PIGA, GPI anchor biosynthesis", "go_ids": ["GO:0006506"], "go_terms": ["GO:0006506:GPI anchor biosynthetic process:P"], "name": "PIGA_GPI_anchor_biosynthesis", "pathway_ids": ["R-HSA-162710", "R-SPO-162710", "R-MMU-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Domain"}, "IPR013235": {"description": "PPP domain", "go_ids": [], "go_terms": [], "name": "PPP_dom", "pathway_ids": ["R-SCE-8939211", "R-MMU-5693565", "R-MMU-8939211", "R-CEL-8939211", "R-HSA-2514859", "R-HSA-8939211", "R-CEL-5675221", "R-MMU-2514859", "R-RNO-5693565", "R-HSA-5693565", "R-RNO-5675221", "R-RNO-8939211", "R-RNO-2514859", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-SCE-8939211:r:ESR-mediated signaling", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-8939211:r:ESR-mediated signaling", "R-CEL-8939211:r:ESR-mediated signaling", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-8939211:r:ESR-mediated signaling", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-8939211:r:ESR-mediated signaling", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR013236": {"description": "M protein trans-acting positive regulator (MGA), PRD domain", "go_ids": [], "go_terms": [], "name": "Mga_PRD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013237": {"description": "DNA primase/helicase Gp4, N-terminal, Bacteriophage T7-like", "go_ids": ["GO:0004386", "GO:0008270"], "go_terms": ["GO:0004386:helicase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Phage_T7_Gp4_N", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR013238": {"description": "RNA polymerase III, subunit Rpc25", "go_ids": [], "go_terms": [], "name": "RNA_pol_III_Rbc25", "pathway_ids": ["R-SCE-76066", "R-DDI-76066", "R-HSA-76071", "R-DDI-76061", "R-SPO-76066", "R-HSA-73980", "R-MMU-76061", "R-HSA-76066", "R-SPO-76061", "R-MMU-76071", "R-HSA-76061", "R-HSA-1834949", "R-MMU-76066", "R-HSA-73780", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR013239": {"description": "RNA polymerase I, subunit Rpa14, fungi", "go_ids": [], "go_terms": [], "name": "RNA_polI_Rpa14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013240": {"description": "DNA-directed RNA polymerase I, subunit RPA34", "go_ids": ["GO:0006360"], "go_terms": ["GO:0006360:transcription by RNA polymerase I:P"], "name": "DNA-dir_RNA_pol1_su_RPA34", "pathway_ids": ["R-HSA-73772", "R-HSA-73863", "R-MMU-73762", "R-MMU-5250924", "R-HSA-427413", "R-HSA-5250924", "R-MMU-73863", "R-MMU-73772", "R-HSA-73762"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Family"}, "IPR013241": {"description": "RNase P, subunit Pop3", "go_ids": ["GO:0006364", "GO:0008033"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0008033:tRNA processing:P"], "name": "RNase_P_Pop3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013243": {"description": "SCA7 domain", "go_ids": [], "go_terms": [], "name": "SCA7_dom", "pathway_ids": ["R-MMU-5689880", "R-HSA-3214847", "R-HSA-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR013244": {"description": "Sec39 domain", "go_ids": ["GO:0006890"], "go_terms": ["GO:0006890:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum:P"], "name": "Sec39_domain", "pathway_ids": ["R-DRE-6811434", "R-HSA-6811434"], "pathways": ["R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR013248": {"description": "Secretory component protein Psh3/Shr3", "go_ids": [], "go_terms": [], "name": "Psh3/Shr3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013249": {"description": "RNA polymerase sigma factor 70, region 4 type 2", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma70_r4_t2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013251": {"description": "DASH complex subunit Spc19", "go_ids": ["GO:0008608", "GO:0042729", "GO:0005876"], "go_terms": ["GO:0008608:attachment of spindle microtubules to kinetochore:P", "GO:0042729:DASH complex:C", "GO:0005876:spindle microtubule:C"], "name": "DASH_Spc19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013252": {"description": "Kinetochore-Ndc80 subunit Spc24", "go_ids": [], "go_terms": [], "name": "Ndc80_Spc24", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-DRE-2500257", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-5663220", "R-HSA-141444", "R-DRE-5663220", "R-DRE-2467813", "R-DRE-141444", "R-HSA-9648025", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR013253": {"description": "Spc7 kinetochore protein domain", "go_ids": [], "go_terms": [], "name": "Spc7_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013254": {"description": "Sperm-activating peptide", "go_ids": [], "go_terms": [], "name": "Sperm_act_pept", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013255": {"description": "Chromosome segregation protein Spc25, C-terminal", "go_ids": ["GO:0007059", "GO:0031262"], "go_terms": ["GO:0007059:chromosome segregation:P", "GO:0031262:Ndc80 complex:C"], "name": "Spc25_C", "pathway_ids": ["R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-BTA-5663220", "R-MMU-68877", "R-BTA-9648025", "R-XTR-68877", "R-RNO-5663220", "R-HSA-9648025", "R-XTR-141444", "R-BTA-2467813", "R-HSA-68877", "R-BTA-2500257", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-MMU-9648025", "R-BTA-141444", "R-XTR-2500257", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Domain"}, "IPR013256": {"description": "Chromatin SPT2", "go_ids": [], "go_terms": [], "name": "Chromatin_SPT2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013257": {"description": "Set2 Rpb1 interacting domain", "go_ids": ["GO:0005694", "GO:0006355"], "go_terms": ["GO:0005694:chromosome:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "SRI", "pathway_ids": ["R-MMU-3214841", "R-HSA-3214841"], "pathways": ["R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines"], "type": "Domain"}, "IPR013258": {"description": "Striatin, N-terminal", "go_ids": [], "go_terms": [], "name": "Striatin_N", "pathway_ids": ["R-HSA-9009391", "R-RNO-6811558", "R-HSA-9673766", "R-HSA-9700645", "R-MMU-6811558", "R-RNO-1257604", "R-RNO-9009391", "R-MMU-9009391", "R-HSA-2219530", "R-HSA-1257604", "R-MMU-1257604", "R-HSA-9725370", "R-HSA-6811558"], "pathways": ["R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9673766:r:Signaling by cytosolic PDGFRA and PDGFRB fusion proteins", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "type": "Domain"}, "IPR013259": {"description": "Sulfakinin", "go_ids": [], "go_terms": [], "name": "Sulfakinin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013260": {"description": "mRNA splicing factor SYF2", "go_ids": [], "go_terms": [], "name": "mRNA_splic_SYF2", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-DME-72163", "R-CEL-72163", "R-SPO-72163", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR013261": {"description": "Mitochondrial import inner membrane translocase subunit Tim21", "go_ids": ["GO:0005744", "GO:0030150"], "go_terms": ["GO:0005744:TIM23 mitochondrial import inner membrane translocase complex:C", "GO:0030150:protein import into mitochondrial matrix:P"], "name": "Tim21", "pathway_ids": ["R-HSA-1268020", "R-MMU-9864848", "R-HSA-9864848"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-9864848:r:Complex IV assembly", "R-HSA-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR013262": {"description": "Outer membrane protein, MIM1/TOM13, mitochondrial", "go_ids": ["GO:0005741"], "go_terms": ["GO:0005741:mitochondrial outer membrane:C"], "name": "OMP_MIM1/TOM13_mt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013263": {"description": "DNA topoisomerase I, zinc ribbon-like, bacterial-type", "go_ids": ["GO:0003917", "GO:0003677", "GO:0006265"], "go_terms": ["GO:0003917:DNA topoisomerase type I (single strand cut, ATP-independent) activity:F", "GO:0003677:DNA binding:F", "GO:0006265:DNA topological change:P"], "name": "TopoI_Znr_bac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013264": {"description": "DNA primase DNAG, catalytic core, N-terminal", "go_ids": [], "go_terms": [], "name": "DNAG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013265": {"description": "TRI9, Fusarium species", "go_ids": [], "go_terms": [], "name": "TRI9_FUSspp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013266": {"description": "Tryptophyllin skin active peptide", "go_ids": [], "go_terms": [], "name": "Tryptophillin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013267": {"description": "Hepatitis TT virus, Orf2a", "go_ids": [], "go_terms": [], "name": "Hepatitis_TTV_Orf2a", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013268": {"description": "U3 small nucleolar RNA-associated protein 16", "go_ids": ["GO:0030515", "GO:0006364"], "go_terms": ["GO:0030515:snoRNA binding:F", "GO:0006364:rRNA processing:P"], "name": "UTP16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013269": {"description": "Herpesvirus UL2", "go_ids": [], "go_terms": [], "name": "Herpes_UL2", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR013270": {"description": "CD47 immunoglobulin-like", "go_ids": [], "go_terms": [], "name": "CD47_Vset", "pathway_ids": ["R-HSA-6798695", "R-SSC-6798695", "R-HSA-216083", "R-RNO-216083", "R-RNO-202733", "R-SSC-391160", "R-MMU-202733", "R-MMU-391160", "R-SSC-216083", "R-MMU-216083", "R-MMU-6798695", "R-RNO-391160", "R-SSC-202733", "R-HSA-202733", "R-RNO-6798695", "R-HSA-391160"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-SSC-216083:r:Integrin cell surface interactions", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-391160:r:Signal regulatory protein family interactions"], "type": "Domain"}, "IPR013272": {"description": "Vps72/YL1, C-terminal", "go_ids": [], "go_terms": [], "name": "Vps72/YL1_C", "pathway_ids": ["R-RNO-5689603", "R-HSA-3214847", "R-HSA-5689603", "R-MMU-5696394", "R-MMU-5689603", "R-RNO-5696394", "R-HSA-5696394"], "pathways": ["R-RNO-5689603:r:UCH proteinases", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH 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modifying enzymes", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-CEL-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Family"}, "IPR013274": {"description": "Peptidase M12B, ADAM-TS1", "go_ids": ["GO:0031012", "GO:0008237", "GO:0008270"], "go_terms": ["GO:0031012:extracellular matrix:C", "GO:0008237:metallopeptidase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Pept_M12B_ADAM-TS1", "pathway_ids": ["PWY-8119", "R-HSA-1474228", "R-RNO-5173214", "R-HSA-5173214", "R-HSA-5083635", "R-MMU-5173214"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Family"}, "IPR013276": {"description": "Peptidase M12B, ADAM-TS5", "go_ids": ["GO:0008237", "GO:0008270", "GO:0031012"], "go_terms": ["GO:0008237:metallopeptidase activity:F", "GO:0008270:zinc ion binding:F", "GO:0031012:extracellular matrix:C"], "name": "Pept_M12B_ADAM-TS5", "pathway_ids": ["R-HSA-1474228", "R-HSA-5173214", "R-HSA-5083635", "R-MMU-5173214", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1474228:r:Degradation of the 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"R-RNO-9013406", "R-RNO-9768727", "R-DME-3134973", "R-HSA-9825892", "R-CEL-525793", "R-DME-209413", "R-RNO-3134973", "R-BTA-9013407", "R-DRE-8853884", "R-HSA-5358749", "R-BTA-418990", "R-DRE-9013106", "R-SSC-418990", "R-DRE-5218920", "R-DME-8980692", "R-HSA-9830364", "R-CEL-9764561", "R-DRE-6805567", "R-SSC-9013406", "R-MMU-3134973", "R-BTA-196299", "R-DRE-4086398", "R-MMU-9762292", "R-DRE-196299", "R-DME-3769402", "R-HSA-8980692", "R-MMU-6809371", "R-MMU-9013406", "R-RNO-8951430", "R-DRE-351906", "R-MMU-6798695", "R-HSA-3134973", "R-CEL-6809371", "R-MMU-9825892", "R-DME-9764561", "R-DME-209421", "R-BTA-9013106", "R-HSA-9013407", "R-SSC-9013148", "R-BTA-9766229", "R-CEL-201681", "R-CEL-3134973", "R-HSA-8853884", "R-HSA-5358751", "R-DME-9825892", "R-BTA-6805567", "R-HSA-6809371", "R-HSA-8951430", "R-HSA-3769402", "R-HSA-5626467", "R-RNO-201722", "R-RNO-9762292", "R-RNO-418990", "R-CEL-201722", "R-DME-525793", "R-DME-195253", "R-CEL-3769402", "R-DME-209214", "R-BTA-9825892", 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"R-HSA-163125", "R-HSA-72163", "R-DDI-5674135", "R-HSA-399954", "R-MMU-5173214", "R-MMU-216083", "R-DRE-201556", "R-MMU-194306", "R-DME-9010553", "R-HSA-9609736", "R-HSA-9833109", "R-RNO-216083", "R-MMU-3232142", "R-CEL-8936459", "R-HSA-9944997", "R-RNO-8980692", "R-BTA-159782", "R-MMU-173623", "R-RNO-8874081", "R-HSA-9717329", "R-HSA-114608", "R-CFA-201556", "R-SPO-9772755", "R-MMU-2672351", "R-MMU-2132295", "R-CEL-72163", "R-RNO-2022870", "R-DME-376176", "R-HSA-159763", "R-BTA-3134975", "R-HSA-9925563", "R-RNO-1650814", "R-RNO-2132295", "R-MMU-3000157", "R-BTA-140875", "R-HSA-72203", "R-MMU-1566977", "R-HSA-3000170", "R-HSA-9770562", "R-RNO-399956", "R-DME-6798695", "R-MMU-5656169", "R-DRE-9851151", "R-HSA-140875", "R-DDI-5675221", "R-DME-351906", "R-MMU-2022090", "R-RNO-9013423", "R-HSA-983170", "R-HSA-933541", "R-HSA-5173214", "R-MMU-159782", "R-HSA-933543", "R-HSA-428540", "R-HSA-428890", "R-BTA-216083", "R-HSA-9725370", "R-HSA-975634", "R-HSA-3595174", "R-HSA-186797", 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"R-DRE-8851805", "R-DME-350379", "R-HSA-399956", "R-RNO-983170", "R-HSA-2132295", "R-HSA-9725554", "R-DRE-9842663", "R-CEL-901042", "R-HSA-977225", "R-RNO-159782", "R-MMU-9755511", "R-MMU-3000480", "R-RNO-114608", "R-HSA-6794361", "R-HSA-918233", "R-HSA-3656253", "R-HSA-977606", "R-RNO-2024101", "R-HSA-2024096", "R-DME-428890", "R-HSA-8851805", "R-DME-450728", "R-BTA-159740", "R-HSA-2214320", "R-HSA-216083", "R-HSA-445355", "R-DDI-3295583", "R-RNO-5578775", "R-RNO-186797", "R-MMU-428890", "R-CEL-3214841", "R-HSA-983168", "R-MMU-1169408", "R-RNO-1442490", "R-DME-201722", "R-RNO-1971475", "R-HSA-9692916", "R-HSA-8957275", "R-CEL-376176", "R-DME-9013423", "R-SCE-9772755", "R-MMU-9909505", "R-RNO-2022090", "R-HSA-8851680", "R-HSA-9833482", "R-DRE-186797", "R-HSA-3560783", "R-HSA-3000178", "R-MMU-9861718", "R-CEL-72203", "R-HSA-9918485", "R-HSA-5689880", "R-RNO-140875", "R-MMU-9013408", "R-DME-1912420", "R-HSA-3656237", "R-HSA-9856532", "R-RNO-140837", "R-BTA-8957275", "R-RNO-901042", "R-DME-390150", "R-DDI-5213460", "R-MMU-8851805", "R-DDI-5673000", "R-HSA-446107", "R-HSA-447038", "R-MMU-5673001", "R-DME-390023", "R-HSA-2122947", "R-HSA-1474228", "R-MMU-3214841", "R-HSA-182971", "R-RNO-1566977", "R-RNO-445144", "R-MMU-72163", "R-RNO-8948216", "R-MMU-9818564", "R-HSA-9660826", "R-HSA-1971475", "R-DME-6809371", "R-DME-9861718", "R-RNO-5689880", "R-HSA-447041", "R-SCE-901042", "R-MMU-9013423", "R-HSA-159740", "R-MMU-376176", "R-HSA-2022090", "R-SSC-3000480", "R-HSA-2022923", "R-SSC-983170", "R-RNO-8951664", "R-MMU-983170", "R-MMU-2024101", "R-HSA-445144", "R-DME-9013700", "R-HSA-1236974", "R-MMU-9851151", "R-HSA-5250992", "R-HSA-9768727", "R-MMU-186797", "R-MMU-9768727", "R-RNO-6798695", "R-DME-983168", "R-HSA-948021", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9772755", "R-HSA-3000480", "R-CFA-9851151", "R-HSA-9694548", "R-HSA-933542", "R-MMU-8980692", "R-HSA-2672351", "R-HSA-3595172", "R-MMU-9020956", "R-HSA-9013106", "R-HSA-5250982", "R-HSA-9717316", "R-HSA-373760", "R-HSA-9861718", "R-HSA-9013423", "R-CEL-9010553", "R-HSA-9638630", "R-MMU-8874081", "R-MMU-159763", "R-HSA-3595177", "R-MMU-2022928", "R-HSA-9717323", "R-MMU-9772755", "R-HSA-2022928", "R-HSA-1442490", "R-CEL-9013423", "R-DRE-9861718", "R-RNO-5694530", "R-HSA-8985801", "R-DDI-901042", "R-HSA-376176", "R-HSA-9913351", "R-DRE-6794361", "R-DME-446107", "R-HSA-9717319", "R-DME-350480", "R-SCE-9013106", "R-MMU-140875", "R-MMU-8851680", "R-HSA-201722", "R-HSA-9909649", "R-MMU-1650814", "R-RNO-399955", "R-HSA-9717326", "R-HSA-9818564", "R-HSA-877300", "R-RNO-2022928", "R-RNO-9770562", "R-HSA-201556", "R-CFA-6798695", "R-MMU-9619665", "R-RNO-3000480", "R-HSA-112314", "R-HSA-9020956", "R-HSA-202733", "R-MMU-373760", "R-DRE-1433557", "R-RNO-419037", "R-BTA-983168", "R-MMU-182971", "R-MMU-204005", "R-MMU-163125", "R-DRE-399954", "R-MMU-159740", "R-MMU-72203", "R-HSA-9700645", "R-HSA-1834941", "R-DME-8951664", "R-DRE-194306", "R-MMU-201722", "R-RNO-9020956", "R-MMU-9013404", "R-MMU-8957275", "R-DME-350376", "R-HSA-1650814", "R-MMU-9833482", "R-MMU-3000178", "R-RNO-202733", "R-HSA-9635465", "R-HSA-381426", "R-DME-9909649", "R-RNO-3000171", "R-HSA-2024101", "R-MMU-8936459", "R-RNO-72203", "R-HSA-9830364", "R-HSA-6784531", "R-MMU-140837", "R-MMU-5578775", "R-HSA-9755511", "R-MMU-445144", "R-HSA-6785807", "R-HSA-9013404", "R-HSA-8980692", "R-BTA-5694530", "R-MMU-9913351", "R-HSA-4420332", "R-HSA-5250958", "R-HSA-3134975", "R-HSA-8948751", "R-CEL-6809371", "R-RNO-983168", "R-MMU-399956", "R-HSA-5617472", "R-MMU-419037", "R-BTA-8951664", "R-HSA-9683686", "R-MMU-2022870", "R-HSA-3769402", "R-HSA-3000157", "R-MMU-8948216", "R-HSA-9619665", "R-MMU-9010553", "R-HSA-936440", "R-DME-350368", "R-HSA-1169408", "R-HSA-5250981", "R-HSA-9909505", "R-DME-901042", "R-BTA-202733", "R-RNO-2672351", "R-BTA-114608", "R-HSA-3214841", "R-RNO-8957275", "R-BTA-381426", "R-HSA-5578775", "R-HSA-9833110", "R-RNO-975634", "R-RNO-9013106", "R-HSA-5656169", "R-HSA-9918481", "R-MMU-8984722", "R-HSA-5083635", "R-HSA-428542", "R-MMU-6794361", "R-MMU-901042", "R-HSA-1566977", "R-HSA-5250968", "R-HSA-1592389", "R-MMU-8985586", "R-HSA-1433557", "R-RNO-204005", "R-RNO-9913351", "R-HSA-9851151", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-DME-8936459", "R-MMU-983168", "R-HSA-8939246", "R-MMU-1971475", "R-MMU-1442490", "R-HSA-163615"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-201556:r:Signaling by ALK", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-373760:r:L1CAM interactions", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-HSA-8948216:r:Collagen chain trimerization", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CEL-9770562:r:mRNA Polyadenylation", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DRE-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-381183:r:ATF6 (ATF6-alpha) activates chaperone genes", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-HSA-5250955:r:Toxicity of botulinum toxin type D (botD)", "R-SSC-901042:r:Calnexin/calreticulin cycle", "R-DRE-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-DRE-201556:r:Signaling by ALK", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-RNO-216083:r:Integrin cell surface interactions", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-RNO-8980692:r:RHOA GTPase cycle", "R-BTA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-9717329:r:lorlatinib-resistant ALK mutants", "R-HSA-114608:r:Platelet degranulation", "R-CFA-201556:r:Signaling by ALK", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-2132295:r:MHC class II antigen presentation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-DME-376176:r:Signaling by ROBO receptors", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-3000157:r:Laminin interactions", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-1566977:r:Fibronectin matrix formation", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-DRE-9851151:r:MDK and PTN in ALK signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-428540:r:Activation of RAC1", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-MMU-9013106:r:RHOC GTPase cycle", 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{"description": "Pilus modification type IV, PilV", "go_ids": [], "go_terms": [], "name": "Pilus_4_PilV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013363": {"description": "Dot/Icm secretion system ATPase DotB", "go_ids": [], "go_terms": [], "name": "Dot_Icm_DotB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013364": {"description": "ATPase, plasmid transfer, TraJ", "go_ids": [], "go_terms": [], "name": "ATPase_plasmid-transfer_TraJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013365": {"description": "Dot/Icm secretion system IcmQ", "go_ids": [], "go_terms": [], "name": "Dot_Icm_IcmQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013366": {"description": "Ethanolamine utilisation EutJ", "go_ids": [], "go_terms": [], "name": "EutJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013367": {"description": "Flagellar, putative", "go_ids": [], "go_terms": [], "name": "Flagellar_put", "pathway_ids": [], "pathways": [], 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"GO:0006754", "GO:0030254", "GO:0030257", "GO:0046961"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006754:ATP biosynthetic process:P", "GO:0030254:protein secretion by the type III secretion system:P", "GO:0030257:type III protein secretion system complex:C", "GO:0046961:proton-transporting ATPase activity, rotational mechanism:F"], "name": "ATPase_T3SS_SctN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013381": {"description": "CRISPR-associated protein Cse1", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cse1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013382": {"description": "CRISPR-associated protein Cse2", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cse2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013383": {"description": "CRISPR-associated protein DxTHG, conserved site", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_DxTHG_CS", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR013384": {"description": "Flagellar hook-associated protein 3", "go_ids": ["GO:0009424", "GO:0071973"], "go_terms": ["GO:0009424:bacterial-type flagellum hook:C", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "Flagell_FlgL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013385": {"description": "Type III secretion system apparatus protein YscQ/HrcQ/SpaO", "go_ids": ["GO:0030254"], "go_terms": ["GO:0030254:protein secretion by the type III secretion system:P"], "name": "T3SS_SpaO/YscQ/SpaO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013387": {"description": "Type III secretion system, PrgH/EprH", "go_ids": [], "go_terms": [], "name": "T3SS_PrgH/EprH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013388": {"description": "Type III secretion apparatus protein OrgA/MxiK", "go_ids": [], "go_terms": [], "name": "T3SS_OrgA/MxiK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013389": {"description": "CRISPR-associated protein Cas8b", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cas8b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013390": {"description": "Type III secretion protein HpaP", "go_ids": [], "go_terms": [], "name": "T3SS_HpaP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013391": {"description": "Type III secretion protein HrpB2", "go_ids": [], "go_terms": [], "name": "T3SS_HrpB2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013392": {"description": "Type III secretion protein HrpB7", "go_ids": [], "go_terms": [], "name": "T3SS_HrpB7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013393": {"description": "Type III secretion protein HrpB4", "go_ids": [], "go_terms": [], "name": "T3SS_HrpB4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013394": {"description": "Type III secretion system, HrpB1/HrpK", "go_ids": [], "go_terms": [], "name": "T3SS_HrpB1/HrpK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013395": {"description": "CRISPR-associated Cas3, Yersinia-type", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Cas3_yers", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013396": {"description": "CRISPR-associated endoribonuclease Cas6/Csy4, subtype I-F/YPEST", "go_ids": ["GO:0043571", "GO:0004519"], "go_terms": ["GO:0043571:maintenance of CRISPR repeat elements:P", "GO:0004519:endonuclease activity:F"], "name": "CRISPR-assoc_prot_Csy4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013397": {"description": "Type I-F CRISPR-associated protein Csy1", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csy1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013398": {"description": "Type I-F CRISPR-associated protein Csy2", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csy2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013399": {"description": "Type I-F CRISPR-associated protein Csy3", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csy3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013401": {"description": "Type III secretion regulator, YopN/LcrE/InvE/MxiC", "go_ids": ["GO:0009986", "GO:0030254", "GO:0050709"], "go_terms": ["GO:0009986:cell surface:C", "GO:0030254:protein secretion by the type III secretion system:P", "GO:0050709:negative regulation of protein secretion:P"], "name": "T3SS_LcrE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013402": {"description": "Conserved hypothetical protein CHP02569", "go_ids": [], "go_terms": [], "name": "CHP02569", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013403": {"description": "Type I-U CRISPR-associated RAMP protein Csb1/Cas7u", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csb1/Cas7u", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013404": {"description": "Competence operon E, ComEB", "go_ids": [], "go_terms": [], "name": "Competence_ComEB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013405": {"description": "Type III secretion system regulator, LcrR", "go_ids": [], "go_terms": [], "name": "T3SS_LcrR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013406": {"description": "Conserved hypothetical protein CHP02574, addiction module", "go_ids": [], "go_terms": [], "name": "CHP02574_addiction_mod", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013407": {"description": "CRISPR-associated protein Cmr2", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cmr2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013408": {"description": "CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1", "go_ids": [], "go_terms": [], "name": "Cas10/Csm1", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Family"}, "IPR013409": {"description": "CRISPR-associated protein Crn3/Csx3", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Crn3/Csx3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013410": {"description": "CRISPR-associated RAMP Cmr4", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_RAMP_Cmr4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013411": {"description": "CRISPR-associated RAMP protein Csx7", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_RAMP_Csx7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013412": {"description": "CRISPR-associated RAMP Csm3", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_RAMP_Csm3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013413": {"description": "CRISPR-associated protein, NE0113", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_NE0113", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013414": {"description": "CRISPR-associated protein Cas7, subtype I-B/Tneap", "go_ids": [], "go_terms": [], "name": "Cas7/Cst2/DevR_sub_I-B/Tneap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013415": {"description": "CRISPR-associated protein Cas5/Cmx5/DevS", "go_ids": ["GO:0051607"], "go_terms": ["GO:0051607:defense response to virus:P"], "name": "Cas5_Cmx5_DevS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013416": {"description": "Conserved hypothetical protein CHP02587, putative integral membrane", "go_ids": [], "go_terms": [], "name": "CHP02587_IM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013417": {"description": "Conserved hypothetical protein CHP02588", "go_ids": [], "go_terms": [], "name": "CHP02588", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013418": {"description": "Type I-C CRISPR-associated protein Cas7/Csd2", "go_ids": ["GO:0043571"], "go_terms": ["GO:0043571:maintenance of CRISPR repeat elements:P"], "name": "CRISPR-assoc_prot_Cas7/Csd2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013419": {"description": "Type I-B CRISPR-associated protein Cas7/Csh2", "go_ids": ["GO:0043571"], "go_terms": ["GO:0043571:maintenance of CRISPR repeat elements:P"], "name": "CRISPR-assoc_prot_Cas7/Csh2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013420": {"description": "Type I-B CRISPR-associated protein Cas8b/Csh1, C-terminal", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cas8b/Csh1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013421": {"description": "Type I-B CRISPR-associated protein Cas5, HALMA", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cas5_HALMA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013422": {"description": "CRISPR-associated protein Cas5, N-terminal", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cas5_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013423": {"description": "Conserved hypothetical protein CHP02594", "go_ids": [], "go_terms": [], "name": "CHP02594", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013424": {"description": "PEP-CTERM protein-sorting domain", "go_ids": [], "go_terms": [], "name": "PEP_exosort_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013425": {"description": "Autotransporter-associated beta strand repeat", "go_ids": [], "go_terms": [], "name": "Autotrns_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR013426": {"description": "Exosortase, EpsH-like", "go_ids": [], "go_terms": [], "name": "EpsH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013427": {"description": "Haem-binding domain, putative", "go_ids": [], "go_terms": [], "name": "Haem-bd_dom_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013429": {"description": "Putative regulatory protein FmdB, zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Regulatory_FmdB_Zinc_ribbon", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013430": {"description": "Toxin-antitoxin system, antidote protein, HigA", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Toxin_antidote_HigA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013431": {"description": "Delta-60 repeat", "go_ids": [], "go_terms": [], "name": "Delta_60_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR013432": {"description": "Putative addiction module antidote", "go_ids": [], "go_terms": [], "name": "Doc_partner", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013433": {"description": "Putative polyhydroxyalkanoic acid system protein", "go_ids": [], "go_terms": [], "name": "PHA_gran_rgn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013434": {"description": "Conserved hypothetical protein CHP02611", "go_ids": [], "go_terms": [], "name": "CHP02611", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013435": {"description": "Mobile mystery protein A", "go_ids": [], "go_terms": [], "name": "Mobile_mystery_prot_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013436": {"description": "Mobile mystery protein B", "go_ids": [], "go_terms": [], "name": "Mobile_mystery_prot_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013437": {"description": "Probable peptidoglycan glycosyltransferase FtsW", "go_ids": ["GO:0009252", "GO:0016020", "GO:0051301"], "go_terms": ["GO:0009252:peptidoglycan biosynthetic process:P", "GO:0016020:membrane:C", "GO:0051301:cell division:P"], "name": "FtsW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013438": {"description": "Sporulation stage V, protein E", "go_ids": [], "go_terms": [], "name": "SpoVE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013440": {"description": "Tryptophanase", "go_ids": ["GO:0009034"], "go_terms": ["GO:0009034:tryptophanase activity:F"], "name": "TNase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013441": {"description": "Tyrosine phenol-lyase", "go_ids": ["GO:0050371", "GO:0006572"], "go_terms": ["GO:0050371:tyrosine phenol-lyase activity:F", "GO:0006572:L-tyrosine catabolic process:P"], "name": "Tyr_phenol_ly", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013442": {"description": "CRISPR system ring nuclease SSO1393-like", "go_ids": [], "go_terms": [], "name": "SSO1393-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013443": {"description": "CRISPR-associated protein Csx16", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csx16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013444": {"description": "Helicase Cas3, CRISPR-associated, Anaes-subtype", "go_ids": [], "go_terms": [], "name": "Helicase_Cas3_CRISPR-ass_Anaes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013445": {"description": "CDP-glucose 4,6-dehydratase", "go_ids": [], "go_terms": [], "name": "CDP_4_6_deHydtase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013446": {"description": "Glucose-1-phosphate cytidylyltransferase-like", "go_ids": ["GO:0047343"], "go_terms": ["GO:0047343:glucose-1-phosphate cytidylyltransferase activity:F"], "name": "G1P_cyt_trans-like", "pathway_ids": ["PWY-8139", "PWY-5940", "PWY-5833"], "pathways": ["PWY-8139:t:CDP-6-deoxy-D-gulose biosynthesis", "PWY-5940:t:streptomycin biosynthesis", "PWY-5833:t:CDP-4-dehydro-3,6-dideoxy-D-glucose biosynthesis"], "type": "Family"}, "IPR013447": {"description": "Rhamnulose-1-phosphate aldolase", "go_ids": ["GO:0008994", "GO:0019301"], "go_terms": ["GO:0008994:rhamnulose-1-phosphate aldolase activity:F", "GO:0019301:rhamnose catabolic process:P"], "name": "Rhamnulose-1-P_Aldolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013448": {"description": "L-rhamnose mutarotase", "go_ids": ["GO:0005737", "GO:0016857"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0016857:racemase and epimerase activity, acting on carbohydrates and derivatives:F"], "name": "L-rhamnose_mutarotase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013449": {"description": "Rhamnulokinase", "go_ids": ["GO:0008993", "GO:0019301"], "go_terms": ["GO:0008993:rhamnulokinase activity:F", "GO:0019301:rhamnose catabolic process:P"], "name": "Rhamnulokinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013450": {"description": "L-fuculokinase", "go_ids": ["GO:0005975", "GO:0008737"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0008737:L-fuculokinase activity:F"], "name": "Fuculokinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013451": {"description": "L-rhamnose catabolism isomerase", "go_ids": [], "go_terms": [], "name": "L_rhamnose_iso", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013452": {"description": "Xylose isomerase, bacterial-type", "go_ids": ["GO:0009045"], "go_terms": ["GO:0009045:xylose isomerase activity:F"], "name": "XylA_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013453": {"description": "Xylose isomerase, actinobacteria", "go_ids": ["GO:0009045", "GO:0042732"], "go_terms": ["GO:0009045:xylose isomerase activity:F", "GO:0042732:D-xylose metabolic process:P"], "name": "XylA_actinobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013454": {"description": "Bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase", "go_ids": [], "go_terms": [], "name": "Bifunc_RhaD/ADH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013455": {"description": "Xylose import ATP-binding protein XylG", "go_ids": ["GO:0005524", "GO:0015614", "GO:0015753", "GO:0016020"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0015614:ABC-type D-xylose transporter activity:F", "GO:0015753:D-xylose transmembrane transport:P", "GO:0016020:membrane:C"], "name": "ABC_transptr_XylG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013456": {"description": "D-xylose-binding periplasmic protein", "go_ids": ["GO:0015753", "GO:0048029"], "go_terms": ["GO:0015753:D-xylose transmembrane transport:P", "GO:0048029:monosaccharide binding:F"], "name": "XylF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013457": {"description": "Rhamnose isomerase-related", "go_ids": [], "go_terms": [], "name": "Rhamnose_iso-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013458": {"description": "Aldose 1-epimerase, bacterial", "go_ids": ["GO:0004034", "GO:0006012"], "go_terms": ["GO:0004034:aldose 1-epimerase activity:F", "GO:0006012:galactose metabolic process:P"], "name": "Ald_epimerase_bac", "pathway_ids": ["PWY-6317"], "pathways": ["PWY-6317:t:D-galactose degradation I (Leloir pathway)"], "type": "Family"}, "IPR013459": {"description": "Rhamnose ABC transporter, substrate-binding protein RhaS", "go_ids": ["GO:0015762"], "go_terms": ["GO:0015762:rhamnose transmembrane transport:P"], "name": "RhaS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013460": {"description": "Lactaldehyde reductase", "go_ids": [], "go_terms": [], "name": "Lactal_redase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013461": {"description": "ATP-dependent Clp protease ATP-binding subunit ClpA", "go_ids": ["GO:0043335", "GO:0016887"], "go_terms": ["GO:0043335:protein unfolding:P", "GO:0016887:ATP hydrolysis activity:F"], "name": "ClpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013462": {"description": "Gas vesicle protein GvpN", "go_ids": ["GO:0000166", "GO:0005524", "GO:0031411", "GO:0031412"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0005524:ATP binding:F", "GO:0031411:gas vesicle:C", "GO:0031412:gas vesicle organization:P"], "name": "Gas-vesicle_GvpN", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Family"}, "IPR013464": {"description": "Conserved hypothetical protein CHP02642", "go_ids": [], "go_terms": [], "name": "CHP02642", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013465": {"description": "Thymidine phosphorylase", "go_ids": ["GO:0009032", "GO:0006213"], "go_terms": ["GO:0009032:thymidine phosphorylase activity:F", "GO:0006213:pyrimidine nucleoside metabolic process:P"], "name": "Thymidine_Pase", "pathway_ids": ["PWY-7181"], "pathways": ["PWY-7181:t:pyrimidine deoxyribonucleosides degradation"], "type": "Family"}, "IPR013466": {"description": "Thymidine phosphorylase/AMP phosphorylase", "go_ids": ["GO:0016763"], "go_terms": ["GO:0016763:pentosyltransferase activity:F"], "name": "Thymidine/AMP_Pase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013467": {"description": "Retron Ec78 putative HNH endonuclease-like", "go_ids": [], "go_terms": [], "name": "HNH78-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013468": {"description": "Conserved hypothetical protein CHP02647", "go_ids": [], "go_terms": [], "name": "CHP02647", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013469": {"description": "Ribonuclease BN", "go_ids": ["GO:0016891"], "go_terms": ["GO:0016891:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism:F"], "name": "Rnase_BN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013470": {"description": "Ribonuclease Z, Thermotoga-type", "go_ids": [], "go_terms": [], "name": "RNase_Z_T_toga", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013471": {"description": "Ribonuclease Z/BN", "go_ids": ["GO:0016891"], "go_terms": ["GO:0016891:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism:F"], "name": "RNase_Z/BN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013472": {"description": "Conserved hypothetical protein CHP02652", "go_ids": [], "go_terms": [], "name": "CHP02652", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013473": {"description": "Lon-like protease BrxL", "go_ids": [], "go_terms": [], "name": "BrxL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013474": {"description": "Circadian clock protein KaiB", "go_ids": ["GO:0007623", "GO:0042326"], "go_terms": ["GO:0007623:circadian rhythm:P", "GO:0042326:negative regulation of phosphorylation:P"], "name": "Circ_KaiB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013475": {"description": "Amicyanin, Paracoccus/Methylobacterium", "go_ids": ["GO:0005507", "GO:0009055"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0009055:electron transfer activity:F"], "name": "Amicyanin_Para/Methyl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013476": {"description": "Methylamine dehydrogenase heavy chain", "go_ids": ["GO:0030058", "GO:0030416", "GO:0042597"], "go_terms": ["GO:0030058:aliphatic amine dehydrogenase activity:F", "GO:0030416:methylamine metabolic process:P", "GO:0042597:periplasmic space:C"], "name": "MeN_DH_Hvc", "pathway_ids": ["PWY-6967"], "pathways": ["PWY-6967:t:methylamine degradation I"], "type": "Family"}, "IPR013477": {"description": "Homocitrate synthase NifV-like", "go_ids": ["GO:0046912"], "go_terms": ["GO:0046912:acyltransferase activity, acyl groups converted into alkyl on transfer:F"], "name": "NifV/FrbC", "pathway_ids": ["PWY-7710", "PWY-3081"], "pathways": ["PWY-7710:t:FeMo cofactor biosynthesis", "PWY-3081:t:L-lysine biosynthesis V"], "type": "Family"}, "IPR013478": {"description": "Methylamine dehydrogenase accessory protein MauD", "go_ids": ["GO:0030416"], "go_terms": ["GO:0030416:methylamine metabolic process:P"], "name": "MeN_DH_accessory", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013479": {"description": "ADP-ribosyl-dinitrogen reductase hydrolase", "go_ids": [], "go_terms": [], "name": "ADP-ribosyl_diN_reduct_hydro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013480": {"description": "Nitrogen fixation protein NifX", "go_ids": ["GO:0009399", "GO:0051540"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0051540:metal cluster binding:F"], "name": "NifX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013481": {"description": "Nitrate reductase maturation protein NarM", "go_ids": [], "go_terms": [], "name": "NarM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013482": {"description": "Molybdenum cofactor guanylyltransferase", "go_ids": ["GO:0003824", "GO:0006777"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0006777:Mo-molybdopterin cofactor biosynthetic process:P"], "name": "Molybde_CF_guanTrfase", "pathway_ids": ["PWY-5964", "PWY-8168"], "pathways": ["PWY-5964:t:guanylyl molybdenum cofactor biosynthesis", "PWY-8168:t:bis(guanylyl tungstenpterin) cofactor biosynthesis"], "type": "Family"}, "IPR013483": {"description": "Molybdenum cofactor biosynthesis protein A", "go_ids": ["GO:0006777", "GO:0046872"], "go_terms": ["GO:0006777:Mo-molybdopterin cofactor biosynthetic process:P", "GO:0046872:metal ion binding:F"], "name": "MoaA", "pathway_ids": ["PWY-6823", "R-DME-947581", "R-BTA-947581", "R-DDI-947581", "R-HSA-947581", "R-MMU-947581"], "pathways": ["PWY-6823:t:molybdopterin biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Family"}, "IPR013484": {"description": "Molybdenum cofactor biosynthesis protein B, proteobacteria", "go_ids": ["GO:0006777"], "go_terms": ["GO:0006777:Mo-molybdopterin cofactor biosynthetic process:P"], "name": "MoaB_proteobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013485": {"description": "Molybdenum cofactor biosynthesis protein A, archaea", "go_ids": ["GO:0006777", "GO:0046872"], "go_terms": ["GO:0006777:Mo-molybdopterin cofactor biosynthetic process:P", "GO:0046872:metal ion binding:F"], "name": "MoaA_arc", "pathway_ids": ["PWY-6823"], "pathways": ["PWY-6823:t:molybdopterin biosynthesis"], "type": "Family"}, "IPR013486": {"description": "Sporulation stage II protein D, amidase enhancer LytB", "go_ids": ["GO:0030435"], "go_terms": ["GO:0030435:sporulation resulting in formation of a cellular spore:P"], "name": "SpoIID/LytB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013487": {"description": "CRISPR-associated protein Csx8", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csx8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013488": {"description": "CRISPR-associated protein Csx9/Cas8a2", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csx9/Cas8a2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013489": {"description": "CRISPR-associated protein Csm6", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csm6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013490": {"description": "CRISPR-associated RAMP Csx10", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_RAMP_Csx10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013491": {"description": "Tape measure protein N-terminal", "go_ids": [], "go_terms": [], "name": "Tape_meas_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013492": {"description": "CRISPR system subtype II-B RNA-guided endonuclease Cas9/Csx12", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Cas9/Csx12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013493": {"description": "Conserved hypothetical protein CHP02677", "go_ids": [], "go_terms": [], "name": "CHP02677", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013494": {"description": "Conserved hypothetical protein CHP02678", "go_ids": [], "go_terms": [], "name": "CHP02678", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013495": {"description": "Conserved hypothetical protein CHP02679", "go_ids": [], "go_terms": [], "name": "CHP02679", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013496": {"description": "Conserved hypothetical protein CHP02680", "go_ids": [], "go_terms": [], "name": "CHP02680", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013497": {"description": "DNA topoisomerase, type IA, central", "go_ids": ["GO:0003677", "GO:0003916", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003916:DNA topoisomerase activity:F", "GO:0006265:DNA topological change:P"], "name": "Topo_IA_cen", "pathway_ids": ["R-DDI-5693616", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-DDI-5693607", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR013498": {"description": "DNA topoisomerase, type IA, zn finger", "go_ids": ["GO:0003677", "GO:0003916", "GO:0005694", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003916:DNA topoisomerase activity:F", "GO:0005694:chromosome:C", "GO:0006265:DNA topological change:P"], "name": "Topo_IA_Znf", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR013499": {"description": "DNA topoisomerase I, eukaryotic-type", "go_ids": ["GO:0003677", "GO:0003917", "GO:0005694", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003917:DNA topoisomerase type I (single strand cut, ATP-independent) activity:F", "GO:0005694:chromosome:C", "GO:0006265:DNA topological change:P"], "name": "TopoI_euk", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-HSA-4615885", "R-SPO-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Domain"}, "IPR013500": {"description": "DNA topoisomerase I, catalytic core, eukaryotic-type", "go_ids": ["GO:0003677", "GO:0006265", "GO:0003917"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006265:DNA topological change:P", "GO:0003917:DNA topoisomerase type I (single strand cut, ATP-independent) activity:F"], "name": "TopoI_cat_euk", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-HSA-4615885", "R-SPO-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Domain"}, "IPR013501": {"description": "Ethanolamine utilization microcompartment shell protein, Lmo1185-like", "go_ids": [], "go_terms": [], "name": "Lmo1185-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013502": {"description": "Uncharacterised protein AF0941", "go_ids": [], "go_terms": [], "name": "Uncharacterised_AF0941", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013503": {"description": "Circadian clock KaiC, bacteria", "go_ids": ["GO:0000287", "GO:0003677", "GO:0004674", "GO:0005524", "GO:0042752", "GO:0006355"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0003677:DNA binding:F", "GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0042752:regulation of circadian rhythm:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Circadian_KaiC_bact", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Family"}, "IPR013504": {"description": "Methylamine/Aralkylamine dehydrogenase light chain, C-terminal domain", "go_ids": ["GO:0009308", "GO:0016638", "GO:0042597"], "go_terms": ["GO:0009308:amine metabolic process:P", "GO:0016638:oxidoreductase activity, acting on the CH-NH2 group of donors:F", "GO:0042597:periplasmic space:C"], "name": "MADH/AADH_Ltc_C_dom", "pathway_ids": ["PWY-6967"], "pathways": ["PWY-6967:t:methylamine degradation I"], "type": "Domain"}, "IPR013506": {"description": "DNA topoisomerase, type IIA, subunit B, domain 2", "go_ids": ["GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F", "GO:0005524:ATP binding:F", "GO:0006265:DNA topological change:P"], "name": "Topo_IIA_bsu_dom2", "pathway_ids": ["R-HSA-9913143", "R-RNO-4615885", "R-HSA-9638771", "R-SCE-4615885", "R-SPO-4615885", "R-HSA-1362277", "R-DME-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9638771:r:Action of antimicrobials", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Domain"}, "IPR013507": {"description": "DNA mismatch repair protein, S5 domain 2-like", "go_ids": ["GO:0005524", "GO:0006298", "GO:0030983"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006298:mismatch repair:P", "GO:0030983:mismatched DNA binding:F"], "name": "DNA_mismatch_S5_2-like", "pathway_ids": ["R-GGA-5358565", "R-RNO-5358565", "R-HSA-5545483", "R-SCE-5358565", "R-SPO-5358565", "R-HSA-912446", "R-HSA-5358606", "R-HSA-5358565", "R-DDI-5358565", "R-HSA-6796648", "R-MMU-5358565", "R-HSA-5632987"], "pathways": ["R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632987:r:Defective Mismatch Repair Associated With PMS2"], "type": "Domain"}, "IPR013509": {"description": "Ribonucleotide reductase large subunit, N-terminal", "go_ids": ["GO:0009263", "GO:0004748", "GO:0005524"], "go_terms": ["GO:0009263:deoxyribonucleotide biosynthetic process:P", "GO:0004748:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor:F", "GO:0005524:ATP binding:F"], "name": "RNR_lsu_N", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210", "R-HSA-5213460", "R-DRE-499943", "R-DME-499943", "R-HSA-9686347", "R-HSA-499943", "R-MMU-499943", "R-CEL-499943"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Domain"}, "IPR013512": {"description": "1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal", "go_ids": ["GO:0070402"], "go_terms": ["GO:0070402:NADPH binding:F"], "name": "DXP_reductoisomerase_N", "pathway_ids": ["PWY-7560"], "pathways": ["PWY-7560:t:methylerythritol phosphate pathway II"], "type": "Domain"}, "IPR013514": {"description": "Protein of unknown function DUF3199, YqbG", "go_ids": [], "go_terms": [], "name": "DUF3199_YqbG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013515": {"description": "Phytochrome specific domain", "go_ids": ["GO:0006355", "GO:0009584"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0009584:detection of visible light:P"], "name": "PHY_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013517": {"description": "FG-GAP repeat", "go_ids": [], "go_terms": [], "name": "FG-GAP", "pathway_ids": ["R-MMU-5674135", "R-RNO-216083", "R-HSA-9725554", "R-HSA-9927426", "R-HSA-3000157", "R-BTA-1566977", "R-CEL-1566977", "R-HSA-1566948", "R-DME-9860927", "R-BTA-202733", "R-MMU-372708", "R-HSA-210990", "R-HSA-114608", "R-DME-1236973", "R-MMU-8874081", "R-RNO-445355", 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"R-CEL-202733", "R-MMU-202733", "R-HSA-9926550", "R-CEL-198933", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-446107", "R-HSA-6802955", "R-HSA-210991", "R-BTA-9634597", "R-HSA-2173789", "R-RNO-3000178", "R-CEL-216083", "R-BTA-198933", "R-HSA-6802948", "R-DME-210991", "R-CEL-9860927", "R-CEL-1236973", "R-MMU-166016", "R-BTA-1566948", "R-DME-114608", "R-MMU-9634597", "R-HSA-8949275", "R-CEL-114608", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-CEL-5674135", "R-DME-354192", "R-HSA-8941332", "R-HSA-447041", "R-RNO-163125", "R-DME-216083", "R-HSA-163125", "R-HSA-75892", "R-DME-445144", "R-MMU-198933", "R-HSA-2022090", "R-MMU-216083", "R-MMU-6798695", "R-HSA-445144", "R-HSA-198933", "R-HSA-9860927", "R-HSA-372708", "R-MMU-354192", "R-MMU-9860927", "R-MMU-446107", "R-HSA-9656223", "R-MMU-114608", "R-DDI-163125", "R-HSA-9634597"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-9725554:r:Differentiation of Keratinocytes 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"R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-9830674:r:Formation of the ureteric bud", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-445355:r:Smooth Muscle Contraction", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", 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interactions", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-BTA-9634597:r:GPER1 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-3000178:r:ECM proteoglycans", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-210991:r:Basigin interactions", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-8949275:r:RUNX3 Regulates Immune Response and Cell Migration", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-DME-354192:r:Integrin signaling", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-HSA-447041:r:CHL1 interactions", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-445144:r:Signal transduction by L1", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-114608:r:Platelet degranulation", "R-DDI-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9634597:r:GPER1 signaling"], "type": "Repeat"}, "IPR013518": {"description": "Potassium channel, inwardly rectifying, Kir, cytoplasmic", "go_ids": [], "go_terms": [], "name": "K_chnl_inward-rec_Kir_cyto", "pathway_ids": ["R-HSA-1296053", "R-SSC-1296053", "R-RNO-1296053", "R-MMU-422356", "R-MMU-1296025", "R-RNO-382556", "R-HSA-5576886", "R-GGA-5576886", "R-MMU-1296067", "R-CEL-1296067", "R-MMU-1296053", "R-CFA-997272", "R-BTA-1296041", "R-RNO-1296025", "R-HSA-9729555", "R-GGA-997272", "R-CFA-1296053", "R-HSA-1296041", "R-HSA-5578775", "R-CEL-5576886", "R-BTA-997272", "R-HSA-1296025", "R-SSC-997272", "R-HSA-997272", "R-HSA-1296067", "R-MMU-382556", "R-SSC-5576886", "R-RNO-997272", "R-RNO-5578775", "R-HSA-382556", "R-MMU-5578775", "R-MMU-5576886", "R-CFA-5576886", "R-MMU-1296041", "R-RNO-5576886", "R-RNO-1296041", "R-HSA-5678420", "R-BTA-1296053", "R-RNO-422356", "R-CEL-1296053", "R-GGA-1296053", "R-RNO-1296067", "R-MMU-997272", "R-BTA-5576886", "R-SSC-1296041", "R-GGA-1296041", "R-CFA-1296041", "R-CEL-997272", "R-CEL-1296041", "R-HSA-5683177", "R-HSA-422356"], "pathways": ["R-HSA-1296053:r:Classical Kir channels", "R-SSC-1296053:r:Classical Kir channels", "R-RNO-1296053:r:Classical Kir channels", "R-MMU-422356:r:Regulation of insulin secretion", "R-MMU-1296025:r:ATP sensitive Potassium channels", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5576886:r:Phase 4 - resting membrane potential", "R-GGA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296067:r:Potassium transport channels", "R-CEL-1296067:r:Potassium transport channels", "R-MMU-1296053:r:Classical Kir channels", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-1296025:r:ATP sensitive Potassium channels", "R-HSA-9729555:r:Sensory perception of sour taste", "R-GGA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CFA-1296053:r:Classical Kir channels", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5578775:r:Ion homeostasis", "R-CEL-5576886:r:Phase 4 - resting membrane potential", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296025:r:ATP sensitive Potassium channels", "R-SSC-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296067:r:Potassium transport channels", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-SSC-5576886:r:Phase 4 - resting membrane potential", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-5576886:r:Phase 4 - resting membrane potential", "R-CFA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-5576886:r:Phase 4 - resting membrane potential", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5678420:r:Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome", "R-BTA-1296053:r:Classical Kir channels", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-1296053:r:Classical Kir channels", "R-GGA-1296053:r:Classical Kir channels", "R-RNO-1296067:r:Potassium transport channels", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-5576886:r:Phase 4 - 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Mammary Gland Luminal Epithelial Cells", "R-MMU-445355:r:Smooth Muscle Contraction", "R-RNO-3000157:r:Laminin interactions", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-BTA-9634597:r:GPER1 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling 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activity", "R-CEL-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-CEL-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-DME-8941326:r:RUNX2 regulates bone development", "R-CEL-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-CEL-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-549127:r:SLC-mediated transport of organic cations", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR013525": {"description": "ABC-2 type transporter, transmembrane domain", "go_ids": ["GO:0016020", "GO:0140359"], "go_terms": ["GO:0016020:membrane:C", "GO:0140359:ABC-type transporter activity:F"], "name": "ABC2_TM", "pathway_ids": ["R-HSA-1989781", "R-HSA-6798695", "R-MMU-9753281", "R-SSC-189483", "R-HSA-9918454", "R-DDI-1660661", "R-RNO-9753281", "R-CEL-6798695", "R-SSC-1660661", "R-HSA-1369062", "R-DDI-189451", "R-MMU-189483", "R-RNO-9793528", "R-CEL-1369062", "R-RNO-189483", "R-MMU-8964058", "R-HSA-2453902", "R-DDI-6798695", "R-DDI-1369062", "R-DDI-5683826", "R-HSA-5682294", "R-SSC-9793528", "R-RNO-917937", "R-HSA-5679090", "R-MMU-2453902", "R-DDI-9793528", "R-DDI-8964058", "R-HSA-2161517", "R-HSA-5683826", "R-SSC-9753281", "R-RNO-1369062", "R-DDI-189483", "R-BTA-2453902", "R-MMU-6798695", "R-HSA-189451", "R-DDI-382556", "R-RNO-189451", "R-HSA-9725554", "R-BTA-382556", "R-MMU-1369062", "R-HSA-5679096", "R-SSC-189451", "R-DME-1660661", "R-HSA-189483", "R-MMU-917937", "R-HSA-9615017", "R-SSC-917937", "R-HSA-5683678", "R-DME-9753281", "R-DME-917937", "R-HSA-9029569", "R-MMU-9029569", "R-MMU-5683826", "R-MMU-382556", "R-HSA-8963896", "R-DME-189451", "R-MMU-189451", "R-HSA-8964058", "R-DDI-917937", "R-HSA-382556", "R-DME-1369062", "R-HSA-9753281", "R-RNO-5683826", "R-HSA-1660661", "R-DDI-8963896", "R-MMU-9793528", "R-HSA-5682113", "R-MMU-8963896", "R-HSA-917937", "R-HSA-9818032", "R-HSA-5688399", "R-RNO-1660661", "R-HSA-9793528", "R-DME-189483", "R-DME-9793528", "R-DDI-2453902", "R-DDI-9753281", "R-MMU-1660661"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9753281:r:Paracetamol ADME", "R-SSC-189483:r:Heme degradation", "R-HSA-9918454:r:Defective visual phototransduction due to ABCA4 loss of function", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-9753281:r:Paracetamol ADME", "R-CEL-6798695:r:Neutrophil degranulation", "R-SSC-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-189451:r:Heme biosynthesis", "R-MMU-189483:r:Heme degradation", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-CEL-1369062:r:ABC transporters in lipid homeostasis", "R-RNO-189483:r:Heme degradation", "R-MMU-8964058:r:HDL remodeling", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-5683826:r:Surfactant metabolism", "R-HSA-5682294:r:Defective ABCA12 causes ARCI4B", "R-SSC-9793528:r:Ciprofloxacin ADME", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-5679090:r:Defective ABCG8 causes GBD4 and sitosterolemia", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DDI-9793528:r:Ciprofloxacin ADME", "R-DDI-8964058:r:HDL remodeling", "R-HSA-2161517:r:Abacavir transmembrane transport", "R-HSA-5683826:r:Surfactant metabolism", "R-SSC-9753281:r:Paracetamol ADME", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-189483:r:Heme degradation", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-189451:r:Heme biosynthesis", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-RNO-189451:r:Heme biosynthesis", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-5679096:r:Defective ABCG5 causes sitosterolemia", "R-SSC-189451:r:Heme biosynthesis", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-189483:r:Heme degradation", "R-MMU-917937:r:Iron uptake and transport", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SSC-917937:r:Iron uptake and transport", "R-HSA-5683678:r:Defective ABCA3 causes SMDP3", "R-DME-9753281:r:Paracetamol ADME", "R-DME-917937:r:Iron uptake and transport", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-8963896:r:HDL assembly", "R-DME-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-HSA-8964058:r:HDL remodeling", "R-DDI-917937:r:Iron uptake and transport", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-DME-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-9753281:r:Paracetamol ADME", "R-RNO-5683826:r:Surfactant metabolism", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-DDI-8963896:r:HDL assembly", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-HSA-5682113:r:Defective ABCA1 causes TGD", "R-MMU-8963896:r:HDL assembly", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-HSA-5688399:r:Defective ABCA3 causes SMDP3", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-DME-189483:r:Heme degradation", "R-DME-9793528:r:Ciprofloxacin ADME", "R-DDI-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DDI-9753281:r:Paracetamol ADME", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Domain"}, "IPR013527": {"description": "Endoribonuclease YicC-like, N-terminal", "go_ids": [], "go_terms": [], "name": "YicC-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013528": {"description": "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal", "go_ids": [], "go_terms": [], "name": "HMG_CoA_synth_N", "pathway_ids": ["PWY-7524", "PWY-7391", "PWY-922", "PWY-8125", "PWY-6174", "PWY-7571", "R-SCE-9969896", "R-HSA-1989781", "R-DDI-9837999", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-77111", "R-RNO-77111", "R-CEL-9969896", "R-MMU-77111", "R-DDI-77111", "R-RNO-9837999", "R-MMU-9969896", "R-HSA-77111", "R-SPO-77111", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-RNO-9969896", "R-SCE-77111", "R-SSC-9837999", "R-DDI-9969896", "R-HSA-9837999", "R-SSC-77111", "R-HSA-2426168", "R-CEL-77111", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["PWY-7524:t:mevalonate pathway III (Thermoplasma)", "PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "PWY-8125:t:mevalonate pathway IV (archaea)", "PWY-6174:t:mevalonate pathway II (haloarchaea)", "PWY-7571:t:ferrichrome A biosynthesis", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-77111:r:Synthesis of Ketone Bodies", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-CEL-9969896:r:Lanosterol biosynthesis", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-DDI-77111:r:Synthesis of Ketone Bodies", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-SPO-77111:r:Synthesis of Ketone Bodies", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-SCE-77111:r:Synthesis of Ketone Bodies", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-77111:r:Synthesis of Ketone Bodies", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-CEL-77111:r:Synthesis of Ketone Bodies", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR013529": {"description": "Glycoside hydrolase, family 42, N-terminal", "go_ids": ["GO:0004565", "GO:0005975", "GO:0009341"], "go_terms": ["GO:0004565:beta-galactosidase activity:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0009341:beta-galactosidase complex:C"], "name": "Glyco_hydro_42_N", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR013530": {"description": "Protein-arginine deiminase, C-terminal", "go_ids": ["GO:0004668", "GO:0005509", "GO:0005737"], "go_terms": ["GO:0004668:protein-arginine deiminase activity:F", "GO:0005509:calcium ion binding:F", "GO:0005737:cytoplasm:C"], "name": "PAD_C", "pathway_ids": ["PWY-4921", "R-MMU-6798695", "R-HSA-6798695", "R-RNO-3247509", "R-RNO-6798695", "R-MMU-3247509", "R-HSA-3247509"], "pathways": ["PWY-4921:t:protein citrullination", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-HSA-3247509:r:Chromatin modifying enzymes"], "type": "Domain"}, "IPR013531": {"description": "Pro-opiomelanocortin/corticotropin, ACTH, central region", "go_ids": [], "go_terms": [], "name": "Mcrtin_ACTH_cent", "pathway_ids": ["R-HSA-375276", "R-BTA-211976", "R-MMU-375276", "R-RNO-193048", "R-MMU-418594", "R-BTA-202040", "R-MMU-209952", "R-RNO-418594", "R-BTA-209952", "R-MMU-202040", "R-BTA-418594", "R-HSA-9615017", "R-HSA-202040", "R-MMU-194002", "R-HSA-193048", "R-MMU-193048", "R-HSA-209952", "R-HSA-111885", "R-RNO-111885", "R-BTA-194002", "R-BTA-111885", "R-MMU-111885", "R-HSA-418555", "R-HSA-6785807", "R-RNO-194002", "R-BTA-193048", "R-RNO-209952", "R-HSA-418594", "R-HSA-5579031", "R-MMU-211976", "R-BTA-418555", "R-RNO-375276", "R-RNO-211976", "R-MMU-418555", "R-HSA-9856649", "R-HSA-211976", "R-RNO-202040", "R-BTA-375276", "R-HSA-194002"], "pathways": ["R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-211976:r:Endogenous sterols", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-193048:r:Androgen biosynthesis", "R-MMU-418594:r:G alpha (i) signalling events", "R-BTA-202040:r:G-protein activation", "R-MMU-209952:r:Peptide hormone biosynthesis", "R-RNO-418594:r:G alpha (i) signalling events", "R-BTA-209952:r:Peptide hormone biosynthesis", "R-MMU-202040:r:G-protein activation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-202040:r:G-protein activation", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-HSA-193048:r:Androgen biosynthesis", "R-MMU-193048:r:Androgen biosynthesis", "R-HSA-209952:r:Peptide hormone biosynthesis", "R-HSA-111885:r:Opioid Signalling", "R-RNO-111885:r:Opioid Signalling", "R-BTA-194002:r:Glucocorticoid biosynthesis", "R-BTA-111885:r:Opioid Signalling", "R-MMU-111885:r:Opioid Signalling", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-194002:r:Glucocorticoid biosynthesis", "R-BTA-193048:r:Androgen biosynthesis", "R-RNO-209952:r:Peptide hormone biosynthesis", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-5579031:r:Defective ACTH causes obesity and POMCD", "R-MMU-211976:r:Endogenous sterols", "R-BTA-418555:r:G alpha (s) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-RNO-211976:r:Endogenous sterols", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-211976:r:Endogenous sterols", "R-RNO-202040:r:G-protein activation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-HSA-194002:r:Glucocorticoid biosynthesis"], "type": "Domain"}, "IPR013532": {"description": "Opiodes neuropeptide", "go_ids": [], "go_terms": [], "name": "Opioid_neuropept", "pathway_ids": ["R-HSA-375276", "R-BTA-211976", "R-MMU-375276", "R-RNO-193048", "R-MMU-418594", "R-BTA-202040", "R-MMU-209952", "R-RNO-418594", "R-BTA-209952", "R-MMU-202040", "R-BTA-418594", "R-HSA-9615017", "R-HSA-202040", "R-MMU-194002", "R-HSA-193048", "R-MMU-193048", "R-HSA-209952", "R-HSA-111885", "R-RNO-111885", "R-BTA-194002", "R-BTA-111885", "R-MMU-111885", "R-HSA-418555", "R-HSA-6785807", "R-RNO-194002", "R-BTA-193048", "R-RNO-209952", "R-HSA-418594", "R-HSA-5579031", "R-MMU-211976", "R-BTA-418555", "R-RNO-375276", "R-RNO-211976", "R-MMU-418555", "R-HSA-9856649", "R-HSA-211976", "R-RNO-202040", "R-BTA-375276", "R-HSA-194002"], "pathways": ["R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-211976:r:Endogenous sterols", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-193048:r:Androgen biosynthesis", "R-MMU-418594:r:G alpha (i) signalling events", "R-BTA-202040:r:G-protein activation", "R-MMU-209952:r:Peptide hormone biosynthesis", "R-RNO-418594:r:G alpha (i) signalling events", "R-BTA-209952:r:Peptide hormone biosynthesis", "R-MMU-202040:r:G-protein activation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-202040:r:G-protein activation", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-HSA-193048:r:Androgen biosynthesis", "R-MMU-193048:r:Androgen biosynthesis", "R-HSA-209952:r:Peptide hormone biosynthesis", "R-HSA-111885:r:Opioid Signalling", "R-RNO-111885:r:Opioid Signalling", "R-BTA-194002:r:Glucocorticoid biosynthesis", "R-BTA-111885:r:Opioid Signalling", "R-MMU-111885:r:Opioid Signalling", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-194002:r:Glucocorticoid biosynthesis", "R-BTA-193048:r:Androgen biosynthesis", "R-RNO-209952:r:Peptide hormone biosynthesis", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-5579031:r:Defective ACTH causes obesity and POMCD", "R-MMU-211976:r:Endogenous sterols", "R-BTA-418555:r:G alpha (s) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-RNO-211976:r:Endogenous sterols", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-211976:r:Endogenous sterols", "R-RNO-202040:r:G-protein activation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-HSA-194002:r:Glucocorticoid biosynthesis"], "type": "Domain"}, "IPR013534": {"description": "Starch synthase, catalytic domain", "go_ids": [], "go_terms": [], "name": "Starch_synth_cat_dom", "pathway_ids": ["PWY-622"], "pathways": ["PWY-622:t:starch biosynthesis"], "type": "Domain"}, "IPR013535": {"description": "PUL domain", "go_ids": [], "go_terms": [], "name": "PUL_dom", "pathway_ids": ["R-SPO-983168", "R-SPO-8951664", "R-SCE-983168"], "pathways": ["R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-8951664:r:Neddylation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR013536": {"description": "WLM domain", "go_ids": [], "go_terms": [], "name": "WLM_dom", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR013537": {"description": "Acetyl-CoA carboxylase, central domain", "go_ids": ["GO:0003989", "GO:0005524", "GO:0006633"], "go_terms": ["GO:0003989:acetyl-CoA carboxylase activity:F", "GO:0005524:ATP binding:F", "GO:0006633:fatty acid biosynthetic process:P"], "name": "AcCoA_COase_cen", "pathway_ids": ["PWY-5743", "PWY-5966", "PWY-5789", "PWY-6679", "PWY-5744", "R-HSA-163765", "R-DDI-75105", "R-MMU-200425", "R-SPO-75105", "R-HSA-196780", "R-RNO-75105", "R-DDI-200425", "R-HSA-3371599", "R-MMU-75105", "R-MMU-196780", "R-SPO-196780", "R-RNO-196780", "R-DDI-196780", "R-HSA-200425", "R-SPO-200425", "R-RNO-200425", "R-HSA-75105", "R-SCE-196780", "R-SCE-200425", "R-HSA-2426168", "R-SCE-75105"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-6679:t:jadomycin biosynthesis", "PWY-5744:t:glyoxylate assimilation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-200425:r:Carnitine shuttle", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-196780:r:Biotin transport and metabolism", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-200425:r:Carnitine shuttle", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-196780:r:Biotin transport and metabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-DDI-196780:r:Biotin transport and metabolism", "R-HSA-200425:r:Carnitine shuttle", "R-SPO-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-196780:r:Biotin transport and metabolism", "R-SCE-200425:r:Carnitine shuttle", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR013538": {"description": "Activator of Hsp90 ATPase homologue 1/2-like, C-terminal", "go_ids": [], "go_terms": [], "name": "ASHA1/2-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013539": {"description": "Adenylosuccinate lyase PurB, C-terminal", "go_ids": ["GO:0004018", "GO:0006188"], "go_terms": ["GO:0004018:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity:F", "GO:0006188:IMP biosynthetic process:P"], "name": "PurB_C", "pathway_ids": ["PWY-7219", "PWY-7234", "PWY-6124", "PWY-6123", "PWY-8289"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "PWY-7234:t:inosine-5'-phosphate biosynthesis III", "PWY-6124:t:inosine-5'-phosphate biosynthesis II", "PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-8289:t:dZTP biosynthesis"], "type": "Domain"}, "IPR013540": {"description": "Chitinase A N-terminal", "go_ids": ["GO:0004568", "GO:0006032"], "go_terms": ["GO:0004568:chitinase activity:F", "GO:0006032:chitin catabolic process:P"], "name": "ChitinaseA_N", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-6855"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-6855:t:chitin degradation I (archaea)"], "type": "Domain"}, "IPR013542": {"description": "Epoxyqueuosine reductase QueG, Cbl-binding domain", "go_ids": [], "go_terms": [], "name": "QueG_Cbl-bind", "pathway_ids": ["PWY-6700", "PWY-8106"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Domain"}, "IPR013543": {"description": "Calcium/calmodulin-dependent protein kinase II, association-domain", "go_ids": ["GO:0004683", "GO:0005516", "GO:0006468"], "go_terms": ["GO:0004683:calcium/calmodulin-dependent protein kinase activity:F", "GO:0005516:calmodulin binding:F", "GO:0006468:protein phosphorylation:P"], "name": "Ca/CaM-dep_prot_kinase-assoc", "pathway_ids": ["R-RNO-877300", "R-HSA-9022692", "R-HSA-6802952", "R-BTA-5673001", "R-MMU-4086398", "R-CEL-438066", "R-BTA-936837", "R-HSA-442982", "R-BTA-5576892", "R-HSA-5673000", "R-DME-3371571", "R-HSA-9649948", "R-CEL-4086398", "R-RNO-3371571", "R-BTA-438066", "R-DRE-877300", "R-SSC-877300", "R-BTA-877300", "R-SSC-3371571", "R-RNO-5673001", "R-MMU-5673001", "R-CEL-936837", "R-DME-438066", "R-DME-5673000", "R-HSA-6802955", "R-RNO-5673000", "R-MMU-438066", "R-MMU-5673000", "R-MMU-5578775", "R-BTA-3371571", "R-RNO-438066", "R-HSA-5673001", "R-SSC-438066", "R-HSA-9620244", "R-BTA-399719", "R-DRE-3371571", "R-BTA-5673000", "R-HSA-9609736", "R-HSA-9656223", "R-DRE-438066", "R-CEL-3371571", "R-HSA-5576892", "R-HSA-6802946", "R-BTA-5578775", "R-HSA-5578775", "R-HSA-111932", "R-HSA-4086398", "R-MMU-936837", "R-HSA-9617324", "R-HSA-9918481", "R-DME-4086398", "R-HSA-442729", "R-HSA-399719", "R-DME-936837", "R-DME-5578775", "R-RNO-5578775", "R-MMU-3371571", "R-HSA-936837", "R-RNO-399719", "R-MMU-877300", "R-RNO-936837", "R-RNO-4086398", "R-SSC-5673001", "R-HSA-438066", "R-CEL-5578775", "R-HSA-877300", "R-HSA-3371571", "R-SSC-399719", "R-MMU-399719"], "pathways": ["R-RNO-877300:r:Interferon gamma signaling", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-MMU-4086398:r:Ca2+ pathway", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-5673000:r:RAF activation", "R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CEL-4086398:r:Ca2+ pathway", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DRE-877300:r:Interferon gamma signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-BTA-877300:r:Interferon gamma signaling", "R-SSC-3371571:r:HSF1-dependent transactivation", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-5673000:r:RAF activation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-RNO-5673000:r:RAF activation", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5673000:r:RAF activation", "R-MMU-5578775:r:Ion homeostasis", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-SSC-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9620244:r:Long-term potentiation", "R-BTA-399719:r:Trafficking of AMPA receptors", "R-DRE-3371571:r:HSF1-dependent transactivation", "R-BTA-5673000:r:RAF activation", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-4086398:r:Ca2+ pathway", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-DME-936837:r:Ion transport by P-type ATPases", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-RNO-4086398:r:Ca2+ pathway", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-5578775:r:Ion homeostasis", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-SSC-399719:r:Trafficking of AMPA receptors", "R-MMU-399719:r:Trafficking of AMPA receptors"], "type": "Domain"}, "IPR013545": {"description": "Type II secretion system protein GspG, C-terminal", "go_ids": [], "go_terms": [], "name": "T2SS_protein-GspG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013546": {"description": "PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase", "go_ids": ["GO:0016779"], "go_terms": ["GO:0016779:nucleotidyltransferase activity:F"], "name": "PII_UdlTrfase/GS_AdlTrfase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013547": {"description": "Prolyl 4-hydroxylase, N-terminal", "go_ids": ["GO:0005783"], "go_terms": ["GO:0005783:endoplasmic reticulum:C"], "name": "P4H_N", "pathway_ids": ["PWY-7894", "R-HSA-1650814", "R-HSA-9918432"], "pathways": ["PWY-7894:t:procollagen hydroxylation and glycosylation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR013548": {"description": "Plexin, cytoplasmic RasGAP domain", "go_ids": ["GO:0017154"], "go_terms": ["GO:0017154:semaphorin receptor activity:F"], "name": "Plexin_cytoplasmic_RasGAP_dom", "pathway_ids": ["R-HSA-9013405", "R-HSA-416550", "R-HSA-399956", "R-HSA-416572", "R-DRE-399954", "R-CEL-416700", "R-CEL-416482", "R-MMU-416572", "R-RNO-399954", "R-HSA-9615017", "R-HSA-416700", "R-MMU-399954", "R-HSA-399955", "R-HSA-9696273", "R-RNO-399956", "R-HSA-9013508", "R-MMU-416700", "R-RNO-416700", "R-HSA-9696270", "R-MMU-399955", "R-HSA-416482", "R-CEL-416572", "R-DME-416572", "R-RNO-399955", "R-HSA-399954", "R-DRE-399956", "R-MMU-416482", "R-DME-416482", "R-DME-416700", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-399956", "R-MMU-416550"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-416700:r:Other semaphorin interactions", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-416700:r:Other semaphorin interactions", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-MMU-416700:r:Other semaphorin interactions", "R-RNO-416700:r:Other semaphorin interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DME-416700:r:Other semaphorin interactions", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration"], "type": "Domain"}, "IPR013549": {"description": "Domain of unknown function DUF1731", "go_ids": [], "go_terms": [], "name": "DUF1731", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013550": {"description": "RTX, C-terminal", "go_ids": [], "go_terms": [], "name": "RTX_C", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR013551": {"description": "Endoribonuclease YicC-like, C-terminal", "go_ids": [], "go_terms": [], "name": "YicC-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013552": {"description": "Thioester domain", "go_ids": [], "go_terms": [], "name": "Thioester_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013554": {"description": "Ribonucleotide reductase N-terminal", "go_ids": [], "go_terms": [], "name": "RNR_N", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR013555": {"description": "Transient receptor ion channel domain", "go_ids": [], "go_terms": [], "name": "TRP_dom", "pathway_ids": ["R-MMU-114508", "R-DME-3295583", "R-BTA-114508", "R-HSA-139853", "R-MMU-139853", "R-HSA-983695", "R-DME-5578775", "R-RNO-5578775", "R-CEL-139853", "R-MMU-5578775", "R-DME-983695", "R-MMU-983695", "R-RNO-3295583", "R-HSA-114508", "R-CEL-3295583", "R-CEL-114508", "R-BTA-139853", "R-RNO-139853", "R-RNO-983695", "R-HSA-418890", "R-HSA-5578775", "R-HSA-9022699", "R-RNO-114508", "R-BTA-3295583", "R-MMU-3295583", "R-HSA-3295583"], "pathways": ["R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-DME-3295583:r:TRP channels", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-CEL-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-5578775:r:Ion homeostasis", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-3295583:r:TRP channels", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-CEL-3295583:r:TRP channels", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-BTA-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-BTA-3295583:r:TRP channels", "R-MMU-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Domain"}, "IPR013556": {"description": "Flagellar M-ring C-terminal", "go_ids": [], "go_terms": [], "name": "Flag_M-ring_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013557": {"description": "AntA/AntB antirepressor", "go_ids": [], "go_terms": [], "name": "AntA/B_antirep", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013558": {"description": "CTNNB1 binding, N-teminal", "go_ids": [], "go_terms": [], "name": "CTNNB1-bd_N", "pathway_ids": ["R-HSA-8853884", "R-RNO-4641265", "R-HSA-3769402", "R-HSA-8951430", "R-RNO-201722", "R-DRE-4641265", "R-DRE-201722", "R-MMU-4086398", "R-MMU-201722", "R-HSA-9824272", "R-HSA-5339700", "R-RNO-9825892", "R-HSA-9823730", "R-HSA-9796292", "R-HSA-9616222", "R-MMU-8951430", "R-HSA-4086398", "R-HSA-381771", "R-HSA-9825892", "R-HSA-9834899", "R-XTR-9825892", "R-DRE-9825892", "R-MMU-3769402", "R-DRE-3769402", "R-XTR-4641265", "R-HSA-4641265", "R-XTR-201722", "R-MMU-4641265", "R-DME-209441", "R-HSA-9824585", "R-HSA-201722", "R-HSA-9754189", "R-XTR-3769402", "R-HSA-9909649", "R-RNO-4086398", "R-HSA-9733709", "R-RNO-8951430", "R-HSA-9793380", "R-HSA-9856649", "R-HSA-4411364", "R-RNO-3769402", "R-MMU-9825892", "R-DME-209421"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-RNO-4641265:r:Repression of WNT target genes", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-8951430:r:RUNX3 regulates WNT signaling", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-4641265:r:Repression of WNT target genes", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9824272:r:Somitogenesis", "R-HSA-5339700:r:Signaling by TCF7L2 mutants", "R-RNO-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9823730:r:Formation of definitive endoderm", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9834899:r:Specification of the neural plate border", "R-XTR-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DRE-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-XTR-4641265:r:Repression of WNT target genes", "R-HSA-4641265:r:Repression of WNT target genes", "R-XTR-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-4641265:r:Repression of WNT target genes", "R-DME-209441:r:WG ligand not bound to FZ receptors", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-XTR-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-4086398:r:Ca2+ pathway", "R-HSA-9733709:r:Cardiogenesis", "R-RNO-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DME-209421:r:Transcription activation by ARM"], "type": "Domain"}, "IPR013559": {"description": "YheO-like", "go_ids": [], "go_terms": [], "name": "YheO", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013560": {"description": "Domain of unknown function DUF1722", "go_ids": [], "go_terms": [], "name": "DUF1722", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013561": {"description": "Methanogenesis regulatory protein FilR1, middle domain", "go_ids": [], "go_terms": [], "name": "FilR1_middle_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013562": {"description": "TmcA/NAT10, N-terminal", "go_ids": [], "go_terms": [], "name": "TmcA/NAT10_N", "pathway_ids": ["R-HSA-6790901"], "pathways": ["R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR013563": {"description": "Oligopeptide/dipeptide ABC transporter, C-terminal", "go_ids": ["GO:0000166", "GO:0005524", "GO:0015833"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0005524:ATP binding:F", "GO:0015833:peptide transport:P"], "name": "Oligopep_ABC_C", "pathway_ids": ["R-HSA-9927020", "R-HSA-1222538"], "pathways": ["R-HSA-9927020:r:Heme assimilation", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Domain"}, "IPR013564": {"description": "Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT, C-terminal", "go_ids": [], "go_terms": [], "name": "MurT_C", "pathway_ids": ["PWY-6471", "PWY-5265"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)"], "type": "Domain"}, "IPR013565": {"description": "Fatty acid synthase beta subunit AflB /Fas1-like, central domain", "go_ids": ["GO:0004318"], "go_terms": ["GO:0004318:enoyl-[acyl-carrier-protein] reductase (NADH) activity:F"], "name": "Fas1/AflB-like_central", "pathway_ids": ["PWY-8174", "PWY-5147", "PWY-5142", "PWY-8427", "PWY-6799", "PWY-8280", "PWY-6519", "PWY-8203", "PWY-7663", "PWY-5367", "PWY-7746", "PWY-8438", "PWY-5989", "PWY-4381", "PWY-5966", "PWY-7723", "PWY-8012", "PWY-5971", "PWY-8173", "PWY-6113", "PWY-5366", "PWY-7664", "PWY-8175", "PWY-7858", "PWY-8049", "PWYG-321", "PWY-7388", "PWY-5994", "PWY-5973", "PWY-8279", "PWY-8047", "PWY-6282"], "pathways": ["PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-5147:t:oleate biosynthesis I (plants)", "PWY-5142:t:acyl-[acyl-carrier protein] thioesterase pathway", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWY-5367:t:petroselinate biosynthesis", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-7723:t:bacterial bioluminescence", "PWY-8012:t:mupirocin biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "PWY-6113:t:superpathway of mycolate biosynthesis", "PWY-5366:t:palmitoleate biosynthesis II (plants and bacteria)", "PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8049:t:pederin biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8279:t:palmitate biosynthesis III", "PWY-8047:t:bryostatin biosynthesis", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"], "type": "Domain"}, "IPR013566": {"description": "Mitochondrial Rho GTPase 1/3, EF hand associated, type-1", "go_ids": [], "go_terms": [], "name": "EF_hand_assoc_1", "pathway_ids": ["R-DRE-5689880", "R-BTA-9013425", "R-CEL-9013419", "R-BTA-5689880", "R-SPO-9013419", "R-HSA-5689880", "R-SPO-9013425", "R-DME-9013419", "R-RNO-9013419", "R-DME-9013425", "R-DDI-9013422", "R-HSA-9013425", "R-GGA-9013419", "R-MMU-5689880", "R-DRE-9013425", "R-SCE-9013425", "R-SCE-9013419", "R-BTA-9013419", "R-XTR-9013419", "R-MMU-9013425", "R-HSA-9013419", "R-CEL-9013425", "R-DRE-9013419", "R-DDI-9013418", "R-DME-5689880", "R-MMU-9013419"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-9013425:r:RHOT1 GTPase cycle", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-GGA-9013419:r:RHOT2 GTPase cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DRE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-BTA-9013419:r:RHOT2 GTPase cycle", "R-XTR-9013419:r:RHOT2 GTPase cycle", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-CEL-9013425:r:RHOT1 GTPase cycle", "R-DRE-9013419:r:RHOT2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-9013419:r:RHOT2 GTPase cycle"], "type": "Domain"}, "IPR013567": {"description": "EF hand associated, type-2", "go_ids": [], "go_terms": [], "name": "EF_hand_assoc_2", "pathway_ids": ["R-DRE-5689880", "R-BTA-9013425", "R-CEL-9013419", "R-BTA-5689880", "R-SPO-9013419", "R-HSA-5689880", "R-SPO-9013425", "R-DME-9013419", "R-RNO-9013419", "R-DME-9013425", "R-DDI-9013422", "R-HSA-9013425", "R-GGA-9013419", "R-MMU-5689880", "R-DRE-9013425", "R-SCE-9013425", "R-SCE-9013419", "R-BTA-9013419", "R-XTR-9013419", "R-MMU-9013425", "R-HSA-9013419", "R-CEL-9013425", "R-DRE-9013419", "R-DDI-9013418", "R-DME-5689880", "R-MMU-9013419"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-9013425:r:RHOT1 GTPase cycle", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-GGA-9013419:r:RHOT2 GTPase cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DRE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-BTA-9013419:r:RHOT2 GTPase cycle", "R-XTR-9013419:r:RHOT2 GTPase cycle", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-CEL-9013425:r:RHOT1 GTPase cycle", "R-DRE-9013419:r:RHOT2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-9013419:r:RHOT2 GTPase cycle"], "type": "Domain"}, "IPR013568": {"description": "SEFIR domain", "go_ids": [], "go_terms": [], "name": "SEFIR_dom", "pathway_ids": ["R-HSA-448424", "R-MMU-5674135", "R-CEL-5674135", "R-HSA-9705671", "R-HSA-5674135", "R-DRE-5674135"], "pathways": ["R-HSA-448424:r:Interleukin-17 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DRE-5674135:r:MAP2K and MAPK activation"], "type": "Domain"}, "IPR013569": {"description": "Carlavirus coat", "go_ids": [], "go_terms": [], "name": "Carlavirus_coat_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013570": {"description": "Transcription regulator YsiA, C-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_YsiA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013571": {"description": "Transcription regulator QacR, C-terminal", "go_ids": ["GO:0003700", "GO:0045892"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "Tscrpt_reg_QacR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013572": {"description": "Transcription regulator MAATS, C-terminal", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Tscrpt_reg_MAATS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013573": {"description": "Transcription regulator YcdC, C-terminal", "go_ids": ["GO:0045892"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "Tscrpt_reg_YcdC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013574": {"description": "Glucan-binding protein C/Surface antigen I/II, V-domain", "go_ids": [], "go_terms": [], "name": "Glucan-bd_C/Surface_Ag-I/II_V", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013575": {"description": "Initiation factor 2 associated domain, bacterial", "go_ids": [], "go_terms": [], "name": "IF2_assoc_dom_bac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013576": {"description": "Insulin-like growth factor II E-peptide, C-terminal", "go_ids": [], "go_terms": [], "name": "IGF2_C", "pathway_ids": ["R-RNO-2404192", "R-HSA-2404192", "R-SSC-381426", "R-SSC-2428933", "R-RNO-2428933", "R-BTA-2428933", "R-BTA-2428928", "R-SSC-114608", "R-HSA-2428933", "R-BTA-2404192", "R-MMU-2404192", "R-RNO-114608", "R-RNO-381426", "R-RNO-2428928", "R-HSA-114608", "R-BTA-114608", "R-MMU-114608", "R-SSC-2404192", "R-MMU-381426", "R-BTA-381426", "R-MMU-2428928", "R-SSC-2428928", "R-HSA-2428928", "R-HSA-381426", "R-MMU-2428933"], "pathways": ["R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-114608:r:Platelet degranulation", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-RNO-114608:r:Platelet degranulation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation", "R-SSC-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2428933:r:SHC-related events triggered by IGF1R"], "type": "Domain"}, "IPR013577": {"description": "Lethal giant larvae homologue 2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LLGL2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013578": {"description": "Peptidase M16C associated", "go_ids": ["GO:0006508"], "go_terms": ["GO:0006508:proteolysis:P"], "name": "Peptidase_M16C_assoc", "pathway_ids": ["PWY-8119", "R-SCE-1268020", "R-XTR-1268020", "R-DRE-1268020", "R-DME-1268020", "R-SPO-1268020", "R-HSA-1268020", "R-MMU-1268020"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-SCE-1268020:r:Mitochondrial protein import", "R-XTR-1268020:r:Mitochondrial protein import", "R-DRE-1268020:r:Mitochondrial protein import", "R-DME-1268020:r:Mitochondrial protein import", "R-SPO-1268020:r:Mitochondrial protein import", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-1268020:r:Mitochondrial protein import"], "type": "Domain"}, "IPR013579": {"description": "FAST kinase-like protein, subdomain 2", "go_ids": [], "go_terms": [], "name": "FAST_2", "pathway_ids": ["R-HSA-9837092", "R-HSA-9937008", "R-HSA-6793080"], "pathways": ["R-HSA-9837092:r:FASTK family proteins regulate processing and stability of mitochondrial RNAs", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Domain"}, "IPR013580": {"description": "Light-independent protochlorophyllide reductase subunit B-like, C-terminal", "go_ids": ["GO:0015979", "GO:0015995", "GO:0016491"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0015995:chlorophyll biosynthetic process:P", "GO:0016491:oxidoreductase activity:F"], "name": "LI-POR_suB-like_C", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Domain"}, "IPR013581": {"description": "Plant PDR ABC transporter associated", "go_ids": [], "go_terms": [], "name": "PDR_assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013583": {"description": "Multiple C2 domain and Transmembrane region Proteins, C-terminal", "go_ids": [], "go_terms": [], "name": "MCTP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013584": {"description": "RAP domain", "go_ids": [], "go_terms": [], "name": "RAP", "pathway_ids": ["R-HSA-9837092", "R-HSA-9937008", "R-HSA-6793080"], "pathways": ["R-HSA-9837092:r:FASTK family proteins regulate processing and stability of mitochondrial RNAs", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Domain"}, "IPR013585": {"description": "Protocadherin", "go_ids": [], "go_terms": [], "name": "Protocadherin", "pathway_ids": ["R-HSA-9013026", "R-HSA-114608", "R-HSA-8980692"], "pathways": ["R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-114608:r:Platelet degranulation", "R-HSA-8980692:r:RHOA GTPase cycle"], "type": "Domain"}, "IPR013586": {"description": "26S proteasome non-ATPase regulatory subunit 3, C-terminal", "go_ids": ["GO:0000502", "GO:0030234", "GO:0042176"], "go_terms": ["GO:0000502:proteasome complex:C", "GO:0030234:enzyme regulator activity:F", "GO:0042176:regulation of protein catabolic process:P"], "name": "PSMD3_C", "pathway_ids": ["R-MMU-450408", "R-HSA-9020702", "R-HSA-174178", "R-HSA-9604323", "R-MMU-8941858", "R-BTA-5689880", "R-CEL-5632684", "R-HSA-5689880", "R-HSA-8951664", "R-HSA-9010553", "R-MMU-174154", "R-MMU-69017", "R-HSA-75815", "R-MMU-9020702", "R-DME-5658442", "R-CEL-8941858", "R-CEL-195253", "R-BTA-9755511", "R-MMU-8948751", "R-DME-8948751", "R-MMU-69481", "R-BTA-350562", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-CEL-1234176", "R-BTA-75815", "R-BTA-1169091", "R-DDI-9929491", "R-MMU-5668541", "R-BTA-69481", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-DME-5676590", "R-BTA-5607761", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-BTA-68867", "R-HSA-1234176", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-MMU-68867", "R-DME-4641257", "R-DME-432524", "R-DDI-174084", "R-MMU-9932298", "R-DME-209461", "R-MMU-1234176", "R-MMU-4641258", "R-DME-75815", "R-DDI-4641258", "R-BTA-69017", "R-HSA-180534", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-8948751", "R-CEL-4608870", "R-MMU-5687128", "R-BTA-4641257", "R-MMU-9766229", "R-DME-5358346", "R-BTA-349425", "R-HSA-174154", "R-DDI-187577", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-MMU-187577", "R-DME-202424", "R-HSA-2467813", "R-DME-187577", "R-DDI-382556", "R-BTA-1236978", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-CEL-9907900", "R-HSA-9824272", "R-MMU-174178", "R-CEL-983168", "R-BTA-4608870", "R-BTA-5676590", "R-DDI-174178", "R-MMU-349425", "R-MMU-8939236", "R-DME-350562", "R-HSA-9907900", "R-CEL-8854050", "R-DME-174084", "R-DME-9907900", "R-BTA-2871837", "R-BTA-174154", "R-DDI-5689603", "R-CEL-75815", "R-DDI-69601", "R-DDI-2467813", "R-DME-9929491", "R-BTA-174184", "R-MMU-9762114", "R-HSA-9762114", "R-MMU-195253", "R-DDI-5689880", "R-MMU-202424", "R-HSA-195253", "R-MMU-382556", "R-HSA-5610780", "R-BTA-8939236", "R-DME-209360", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-187577", "R-BTA-9931269", "R-CEL-9755511", "R-DME-6798695", "R-DDI-9907900", "R-SCE-1236978", "R-DME-8939236", "R-MMU-1169091", "R-DME-174184", "R-DME-432626", "R-BTA-9929356", "R-MMU-5607761", "R-MMU-5676590", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-MMU-174184", "R-MMU-8939902", "R-DME-174178", "R-DME-9932298", "R-BTA-9954709", "R-DME-9020702", "R-HSA-8939236", "R-CEL-9762114", "R-SPO-350562", "R-HSA-5358346", "R-DME-5689880", "R-CEL-8951664", "R-HSA-6798695", "R-DDI-8854050", "R-BTA-983168", "R-MMU-5632684", "R-MMU-5607764", "R-SPO-9907900", "R-BTA-5610785", "R-BTA-202424", "R-MMU-2467813", "R-DME-8951664", "R-HSA-9932298", "R-CEL-6798695", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577", "R-HSA-5676590", "R-BTA-6798695", "R-DDI-1236978", "R-DDI-5632684", "R-DDI-8951664", "R-MMU-8951664", "R-BTA-9929491", "R-DME-8939902", "R-CEL-5689603", "R-CEL-382556", "R-HSA-4641257", "R-MMU-9929491", "R-HSA-174113", "R-MMU-9929356", "R-BTA-9932298", "R-BTA-9762114", "R-DME-4608870", "R-SCE-5668541", "R-DDI-174154", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-HSA-69481", "R-DME-9762114", "R-CEL-4641258", "R-BTA-174084", "R-DDI-5658442", "R-BTA-450408", "R-BTA-5687128", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-HSA-9755511", "R-HSA-4641258", "R-CEL-9929491", "R-SPO-5689603", "R-DME-9755511", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-HSA-1169091", "R-CEL-69017", "R-HSA-4608870", "R-HSA-5658442", "R-MMU-2871837", "R-MMU-4641257", "R-BTA-8852276", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-DME-8941858", "R-BTA-8951664", "R-SPO-6798695", "R-HSA-187577", "R-MMU-5610780", "R-DME-1169091", "R-DME-9954709", "R-DDI-9755511", "R-BTA-382556", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-BTA-8941858", "R-DME-4641258", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-350562", "R-MMU-9954709", "R-DME-195253", "R-MMU-69601", "R-DDI-75815", "R-HSA-2871837", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DME-5689603", "R-DME-5607761", "R-MMU-5658442", "R-MMU-5689603", "R-DME-216167", "R-HSA-174084", "R-DDI-9954709", "R-MMU-4608870", "R-HSA-5607764", "R-BTA-174178", "R-DME-68949", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-BTA-8948751", "R-CEL-1236978", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-69601", "R-DME-5632684", "R-HSA-5687128", "R-CEL-68949", "R-DME-432395", "R-HSA-69017", "R-DDI-349425", "R-BTA-9020702", "R-MMU-983168", "R-BTA-5607764", "R-DDI-450408", "R-BTA-1234176", "R-MMU-1236978", "R-CEL-350562", "R-HSA-350562", "R-HSA-202424", "R-BTA-5689603", "R-CEL-4641257", "R-DME-68867"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-5689880:r:Ub-specific processing proteases", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69481:r:G2/M Checkpoints", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-9766229:r:Degradation of CDH1", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-202424:r:Downstream TCR signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9907900:r:Proteasome assembly", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-9907900:r:Proteasome assembly", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-432626:r:Circadian Clock pathway", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-8951664:r:Neddylation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-HSA-4641257:r:Degradation of AXIN", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-5689603:r:UCH proteinases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5689603:r:UCH proteinases", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-8951664:r:Neddylation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-75815:r:Ubiquitin-dependent degradation 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mitosis", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-68949:r:Orc1 removal from chromatin", "R-DME-432395:r:Degradation of TIM", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-BTA-5689603:r:UCH proteinases", "R-CEL-4641257:r:Degradation of AXIN", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR013587": {"description": "Nitrate/nitrite sensing protein", "go_ids": [], "go_terms": [], "name": "Nitrate/nitrite_sensing", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013588": {"description": "MAP2/Tau projection", "go_ids": [], "go_terms": [], "name": "MAP2_projctn", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013589": {"description": "Bacterial transglutaminase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Bac_transglu_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013591": {"description": "Brevis radix (BRX) domain", "go_ids": [], 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"go_terms": [], "name": "Exportin-1/Importin-b-like", "pathway_ids": ["R-MMU-9856649", "R-DME-69273", "R-DME-9634638", "R-HSA-2467813", "R-HSA-3769402", "R-SPO-5687128", "R-DME-9707616", "R-RNO-2500257", "R-MMU-2467813", "R-SCE-9856649", "R-HSA-69273", "R-RNO-450520", "R-RNO-5687128", "R-MMU-68877", "R-RNO-9634638", "R-HSA-168333", "R-HSA-9828806", "R-HSA-203927", "R-HSA-68877", "R-MMU-9707616", "R-HSA-165054", "R-RNO-9707616", "R-RNO-141444", "R-MMU-9648025", "R-MMU-2500257", "R-MMU-3769402", "R-RNO-68877", "R-HSA-2500257", "R-DDI-5687128", "R-MMU-141444", "R-RNO-9856649", "R-HSA-9918432", "R-HSA-6784531", "R-DME-9856649", "R-HSA-141444", "R-HSA-450520", "R-HSA-9707616", "R-MMU-450520", "R-HSA-9648025", "R-DME-450520", "R-HSA-9634638", "R-RNO-5663220", "R-RNO-69273", "R-DME-3769402", "R-HSA-5687128", "R-HSA-9856649", "R-HSA-5663220", "R-MMU-9634638", "R-MMU-5687128", "R-SCE-5687128", "R-MMU-69273", "R-HSA-2173788", "R-RNO-9648025", "R-RNO-2467813", "R-RNO-3769402", "R-MMU-5663220", "R-HSA-9768919"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-DME-9707616:r:Heme signaling", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-9707616:r:Heme signaling", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-9707616:r:Heme signaling", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9707616:r:Heme signaling", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Domain"}, "IPR013600": {"description": "Ly49-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Ly49_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013601": {"description": "FAE1/Type III polyketide synthase-like protein", "go_ids": ["GO:0006633", "GO:0016020", "GO:0016747"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P", "GO:0016020:membrane:C", "GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "FAE1_typ3_polyketide_synth", "pathway_ids": ["PWY-7602", "PWY-7619", "PWY-5080", "PWY-7725", "PWY-8041", "PWY-7724", "PWY-7036", "PWY-7035", "PWY-7601", "PWY-6598", "PWY-6433", "PWY-5972"], "pathways": ["PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-7619:t:juniperonate biosynthesis", "PWY-5080:t:very long chain fatty acid biosynthesis I", "PWY-7725:t:arachidonate biosynthesis V (8-detaturase, mammals)", "PWY-8041:t:ultra-long-chain fatty acid biosynthesis", "PWY-7724:t:icosapentaenoate biosynthesis III (8-desaturase, mammals)", "PWY-7036:t:very long chain fatty acid biosynthesis II", "PWY-7035:t:(9Z)-tricosene biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-6598:t:sciadonate biosynthesis", "PWY-6433:t:hydroxylated fatty acid biosynthesis (plants)", "PWY-5972:t:stearate biosynthesis I (animals)"], "type": "Domain"}, "IPR013602": {"description": "Dynein heavy chain, linker", "go_ids": [], "go_terms": [], "name": "Dhc_linker", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR013603": {"description": "TRASH transcription regulator C-terminal, prokaryotic", "go_ids": [], "go_terms": [], "name": "TRASH_TR_C_prok", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013604": {"description": "7TM chemosensory receptor", "go_ids": ["GO:0016020", "GO:0050909"], "go_terms": ["GO:0016020:membrane:C", "GO:0050909:sensory perception of taste:P"], "name": "7TM_chemorcpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013605": {"description": "Spider toxin omega agotoxin/Tx1 family", "go_ids": ["GO:0090729"], "go_terms": ["GO:0090729:toxin activity:F"], "name": "Toxin_34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013606": {"description": "IMD/I-BAR domain", "go_ids": ["GO:0007009"], "go_terms": ["GO:0007009:plasma membrane organization:P"], "name": "I-BAR_dom", "pathway_ids": ["R-BTA-2029482", "R-HSA-5663213", "R-MMU-9035034", "R-HSA-9664422", "R-RNO-9035034", "R-RNO-9013149", "R-HSA-2029482", "R-MMU-4420097", "R-MMU-9013404", "R-MMU-2029482", "R-RNO-2029482", "R-BTA-9013423", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013423", "R-RNO-5663213", "R-HSA-9013149", "R-MMU-5663213", "R-BTA-5663213", "R-HSA-9013404", "R-HSA-4420097", "R-DRE-9035034", "R-HSA-9035034", "R-HSA-9013148", "R-RNO-9013404", "R-MMU-9013149", "R-RNO-4420097"], "pathways": ["R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-9035034:r:RHOF GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR013607": {"description": "Phospholipase A2-like domain", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Phospholipase_A2-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013608": {"description": "VWA N-terminal", "go_ids": [], "go_terms": [], "name": "VWA_N", "pathway_ids": ["R-RNO-5576893", "R-CEL-5576892", "R-MMU-422356", "R-RNO-112308", "R-MMU-5576892", "R-HSA-400042", "R-HSA-9856532", "R-CEL-422356", "R-HSA-5576892", "R-CEL-5576893", "R-RNO-422356", "R-MMU-5576893", "R-HSA-5576893", "R-HSA-9662360", "R-CEL-112308", "R-HSA-422356", "R-HSA-112308", "R-MMU-112308", "R-RNO-5576892"], "pathways": ["R-RNO-5576893:r:Phase 2 - plateau phase", "R-CEL-5576892:r:Phase 0 - rapid depolarisation", "R-MMU-422356:r:Regulation of insulin secretion", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-CEL-422356:r:Regulation of insulin secretion", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-CEL-5576893:r:Phase 2 - plateau phase", "R-RNO-422356:r:Regulation of insulin secretion", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CEL-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-RNO-5576892:r:Phase 0 - rapid depolarisation"], "type": "Domain"}, "IPR013609": {"description": "Lambda-like tail fibre protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Stf-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013610": {"description": "ArdC, N-terminal ssDNA binding domain", "go_ids": ["GO:0003697"], "go_terms": ["GO:0003697:single-stranded DNA binding:F"], "name": "ArdC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013611": {"description": "Transport-associated OB, type 2", "go_ids": ["GO:0005524", "GO:0043190", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0043190:ATP-binding cassette (ABC) transporter complex:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "Transp-assoc_OB_typ2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013612": {"description": "Amino acid permease, N-terminal", "go_ids": [], "go_terms": [], "name": "AA_permease_N", "pathway_ids": ["R-DRE-426117", "R-HSA-5619087", "R-MMU-426117", "R-RNO-426117", "R-HSA-5619104", "R-HSA-426117"], "pathways": ["R-DRE-426117:r:Cation-coupled Chloride cotransporters", "R-HSA-5619087:r:Defective SLC12A3 causes Gitelman syndrome (GS)", "R-MMU-426117:r:Cation-coupled Chloride cotransporters", "R-RNO-426117:r:Cation-coupled Chloride cotransporters", "R-HSA-5619104:r:Defective SLC12A1 causes Bartter syndrome 1 (BS1)", "R-HSA-426117:r:Cation-coupled Chloride cotransporters"], "type": "Domain"}, "IPR013613": {"description": "Baculoviridae p74 N-terminal", "go_ids": [], "go_terms": [], "name": "Baculo_p74_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013614": {"description": "Viral polyprotein, Caliciviridae N-terminal", "go_ids": ["GO:0003968", "GO:0004197", "GO:0017111", "GO:0044419"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0004197:cysteine-type endopeptidase activity:F", "GO:0017111:ribonucleoside triphosphate phosphatase activity:F", "GO:0044419:biological process involved in interspecies interaction between organisms:P"], "name": "Viral_PP_Calicivir_N", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR013615": {"description": "CbbQ/NirQ/NorQ, C-terminal", "go_ids": [], "go_terms": [], "name": "CbbQ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013616": {"description": "Chitin synthase N-terminal", "go_ids": ["GO:0004100"], "go_terms": ["GO:0004100:chitin synthase activity:F"], "name": "Chitin_synth_N", "pathway_ids": ["PWY-6981"], "pathways": ["PWY-6981:t:chitin biosynthesis"], "type": "Domain"}, "IPR013617": {"description": "DNA-directed DNA polymerase, family B, viral insert domain", "go_ids": ["GO:0003887"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F"], "name": "DNA-dir_DNA_pol_B_vir_insert", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013618": {"description": "Protein O-mannosyl-transferase TMTC, DUF1736", "go_ids": [], "go_terms": [], "name": "TMTC_DUF1736", "pathway_ids": ["PWY-7922", "PWY-7921", "PWY-7979"], "pathways": ["PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-7979:t:protein O-mannosylation III (mammals, core M3)"], "type": "Domain"}, "IPR013619": {"description": "Domain of unknown function DUF1737", "go_ids": [], "go_terms": [], "name": "DUF1737", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013620": {"description": "Exodeoxyribonuclease I, SH3 domain", "go_ids": ["GO:0008310", "GO:0006281"], "go_terms": ["GO:0008310:single-stranded DNA 3'-5' DNA exonuclease activity:F", "GO:0006281:DNA repair:P"], "name": "Exonuc_1_SH3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013621": {"description": "Ion transport N-terminal", "go_ids": [], "go_terms": [], "name": "Ion_trans_N", "pathway_ids": ["R-HSA-1296061", "R-RNO-1296061", "R-MMU-1296061"], "pathways": ["R-HSA-1296061:r:HCN channels", "R-RNO-1296061:r:HCN channels", "R-MMU-1296061:r:HCN channels"], "type": "Domain"}, "IPR013623": {"description": "NADPH oxidase Respiratory burst", "go_ids": ["GO:0004601", "GO:0050664"], "go_terms": ["GO:0004601:peroxidase activity:F", "GO:0050664:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor:F"], "name": "NADPH_Ox", "pathway_ids": ["PWY-5292"], "pathways": ["PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis"], "type": "Domain"}, "IPR013625": {"description": "Tensin/EPS8 phosphotyrosine-binding domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "PTB", "pathway_ids": ["R-RNO-8875513", "R-MMU-8875513", "R-BTA-8875513", "R-HSA-8875513", "R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-RNO-8875513:r:MET interacts with TNS proteins", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-BTA-8875513:r:MET interacts with TNS proteins", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR013626": {"description": "Pheophorbide a oxygenase", "go_ids": ["GO:0010277"], "go_terms": ["GO:0010277:chlorophyllide a oxygenase activity:F"], "name": "PaO", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013627": {"description": "DNA polymerase alpha, subunit B, N-terminal", "go_ids": [], "go_terms": [], "name": "Pol_alpha_B_N", "pathway_ids": ["R-HSA-113501", "R-MMU-174430", "R-RNO-68962", "R-CEL-69091", "R-HSA-68952", "R-CEL-68962", "R-MMU-68962", "R-RNO-174430", "R-HSA-174430", "R-MMU-113501", "R-CEL-113501", "R-DME-69091", "R-CEL-69166", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-DME-113501", "R-RNO-69091", "R-RNO-69183", "R-MMU-68952", "R-HSA-9710421", "R-DME-68962", "R-RNO-69166", "R-RNO-113501", "R-CEL-69183", "R-CEL-68952", "R-MMU-69166", "R-HSA-69183", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-HSA-69091", "R-RNO-68952", "R-MMU-174411", "R-RNO-174411", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-CEL-69091:r:Polymerase switching", "R-HSA-68952:r:DNA replication initiation", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-69091:r:Polymerase switching", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69091:r:Polymerase switching", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-MMU-68952:r:DNA replication initiation", "R-HSA-9710421:r:Defective pyroptosis", "R-DME-68962:r:Activation of the pre-replicative complex", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-CEL-68952:r:DNA replication initiation", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-HSA-69091:r:Polymerase switching", "R-RNO-68952:r:DNA replication initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Domain"}, "IPR013630": {"description": "Methyltransferase putative zinc binding domain", "go_ids": [], "go_terms": [], "name": "Methyltransf_Zn-bd_dom_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013632": {"description": "Rad51-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Rad51_C", "pathway_ids": ["R-GGA-912446", "R-GGA-5685938", "R-HSA-5685942", "R-GGA-5685942", "R-HSA-5693616", "R-BTA-5685938", "R-HSA-9704646", "R-GGA-351433", "R-GGA-5693616", "R-GGA-265976", "R-MMU-5693616", "R-MMU-983231", "R-HSA-6796648", "R-HSA-8953750", "R-MMU-5685938", "R-DME-5693616", "R-BTA-912446", "R-CFA-5693568", "R-HSA-9709570", "R-HSA-912446", "R-BTA-5693616", "R-SCE-5693616", "R-SPO-5693616", "R-BTA-5693579", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-HSA-9701192", "R-DDI-5693616", "R-BTA-5693568", "R-GGA-5693568", "R-HSA-983231", "R-HSA-9709603", "R-MMU-5685942", "R-MMU-912446", "R-CFA-912446", "R-CFA-5685942", "R-CFA-5685938", "R-CFA-5693579", "R-HSA-9704331", "R-CFA-5693616", "R-BTA-5685942", "R-HSA-5693554", "R-HSA-5693579", "R-GGA-5693579"], "pathways": ["R-GGA-912446:r:Meiotic recombination", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-GGA-265976:r:Homologous DNA pairing and strand exchange", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DME-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-912446:r:Meiotic recombination", "R-CFA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-912446:r:Meiotic recombination", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SCE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-GGA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-912446:r:Meiotic recombination", "R-CFA-912446:r:Meiotic recombination", "R-CFA-5685942:r:HDR through Homologous Recombination (HRR)", "R-CFA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CFA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-CFA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-GGA-5693579:r:Homologous DNA Pairing and Strand Exchange"], "type": "Domain"}, "IPR013633": {"description": "siRNA-mediated silencing protein NRDE-2", "go_ids": [], "go_terms": [], "name": "NRDE-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013635": {"description": "Protein Ice2", "go_ids": [], "go_terms": [], "name": "Ice2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013636": {"description": "Armadillo-like helical domain-containing protein 3, C-terminal", "go_ids": [], "go_terms": [], "name": "ARMH3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013637": {"description": "Lysine-specific demethylase-like domain", "go_ids": [], "go_terms": [], "name": "Lys_sp_deMease-like_dom", "pathway_ids": ["R-HSA-8866911", "R-MMU-8866911", "R-DRE-3214842", "R-MMU-3214842", "R-DME-8866911", "R-HSA-9821002", "R-HSA-3214842", "R-CEL-3214842", "R-DRE-8866911"], "pathways": ["R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-MMU-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-DRE-3214842:r:HDMs demethylate histones", "R-MMU-3214842:r:HDMs demethylate histones", "R-DME-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-3214842:r:HDMs demethylate histones", "R-CEL-3214842:r:HDMs demethylate histones", "R-DRE-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "type": "Domain"}, "IPR013638": {"description": "Fork-head N-terminal", "go_ids": ["GO:0019904", "GO:0008134"], "go_terms": ["GO:0019904:protein domain specific binding:F", "GO:0008134:transcription factor binding:F"], "name": "Fork-head_N", "pathway_ids": ["R-HSA-9925563", "R-HSA-9823730", "R-XTR-9018519", "R-DME-9018519", "R-HSA-9796292", "R-HSA-9937080", "R-HSA-210745", "R-HSA-9925561", "R-HSA-9764790", "R-RNO-9018519", "R-HSA-9018519", "R-MMU-9018519"], "pathways": ["R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-9823730:r:Formation of definitive endoderm", "R-XTR-9018519:r:Estrogen-dependent gene expression", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR013640": {"description": "VPS4-associated protein 1", "go_ids": [], "go_terms": [], "name": "Vfa1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013641": {"description": "Protein KTI12/L-seryl-tRNA(Sec) kinase", "go_ids": [], "go_terms": [], "name": "KTI12/PSTK", "pathway_ids": ["R-HSA-2408557"], "pathways": ["R-HSA-2408557:r:Selenocysteine synthesis"], "type": "Family"}, "IPR013642": {"description": "Calcium-activated chloride channel, N-terminal", "go_ids": [], "go_terms": [], "name": "CLCA_N", "pathway_ids": ["R-MMU-2672351", "R-HSA-2672351"], "pathways": ["R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels"], "type": "Domain"}, "IPR013643": {"description": "Calicivirus coat protein C-terminal", "go_ids": [], "go_terms": [], "name": "Calicivirus_coat_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013644": {"description": "1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "DXP_reductoisomerase_C", "pathway_ids": ["PWY-7560"], "pathways": ["PWY-7560:t:methylerythritol phosphate pathway II"], "type": "Domain"}, "IPR013645": {"description": "Glycosyl transferase, family 8, C-terminal", "go_ids": ["GO:0008918", "GO:0009103"], "go_terms": ["GO:0008918:lipopolysaccharide 3-alpha-galactosyltransferase activity:F", "GO:0009103:lipopolysaccharide biosynthetic process:P"], "name": "Glyco_transf_8N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013646": {"description": "Obg-like GTPase YGR210-like, G4 motif-containing domain", "go_ids": [], "go_terms": [], "name": "YGR210-like_G4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013647": {"description": "Oligopeptidase F, N-terminal domain", "go_ids": [], "go_terms": [], "name": "OligopepF_N_dom", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR013648": {"description": "Polyprotein, Potyviridae", "go_ids": ["GO:0003968", "GO:0005198", "GO:0016818", "GO:0018144"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0005198:structural molecule activity:F", "GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F", "GO:0018144:RNA-protein covalent cross-linking:P"], "name": "PP_Potyviridae", "pathway_ids": ["PWY-7884", "PWY-7250"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR013649": {"description": "Integrin alpha, first immunoglubulin-like domain", "go_ids": [], "go_terms": [], "name": "Integrin_alpha_Ig-like_1", "pathway_ids": ["R-DME-2173789", "R-HSA-6798695", "R-HSA-8874081", "R-HSA-5674135", "R-MMU-210991", "R-HSA-6802952", "R-HSA-3000178", "R-HSA-8936459", "R-DME-198933", "R-HSA-166016", "R-CEL-354194", "R-CEL-6798695", "R-MMU-210990", "R-BTA-6798695", "R-CEL-3000178", "R-HSA-9856532", "R-CEL-1566948", "R-MMU-4420097", "R-DME-445355", "R-HSA-9927418", "R-MMU-445355", "R-RNO-3000157", "R-MMU-3000170", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-CEL-202733", "R-MMU-202733", "R-CEL-198933", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-446107", "R-HSA-6802955", "R-HSA-210991", "R-BTA-9634597", "R-HSA-2173789", "R-RNO-3000178", "R-CEL-216083", "R-BTA-198933", "R-HSA-6802948", "R-DME-210991", "R-CEL-9860927", "R-CEL-1236973", "R-MMU-166016", "R-BTA-1566948", "R-DME-114608", "R-MMU-9634597", "R-HSA-8949275", "R-CEL-114608", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-CEL-5674135", "R-DME-354192", "R-HSA-8941332", "R-HSA-447041", "R-DME-216083", "R-HSA-75892", "R-DME-445144", "R-MMU-198933", "R-HSA-2022090", "R-MMU-216083", "R-MMU-6798695", "R-HSA-445144", "R-HSA-198933", "R-HSA-9860927", "R-HSA-372708", "R-MMU-354192", "R-MMU-9860927", "R-MMU-446107", "R-HSA-9656223", "R-MMU-114608", "R-HSA-9634597", "R-MMU-5674135", "R-RNO-216083", "R-HSA-9725554", "R-HSA-9927426", "R-HSA-3000157", "R-BTA-1566977", "R-CEL-1566977", "R-HSA-1566948", "R-DME-9860927", "R-BTA-202733", "R-MMU-372708", "R-HSA-210990", "R-HSA-114608", "R-DME-1236973", "R-MMU-8874081", "R-RNO-445355", "R-HSA-416700", "R-HSA-6802946", "R-CEL-354192", "R-DME-2129379", "R-HSA-9938206", "R-HSA-354192", "R-MMU-3000157", "R-BTA-8874081", "R-MMU-2173789", "R-DME-202733", "R-HSA-216083", "R-HSA-2129379", "R-HSA-3000170", "R-MMU-1566977", "R-DME-6798695", "R-CEL-210991", "R-HSA-1566977", "R-CEL-445144", "R-HSA-445355", "R-HSA-9927432", "R-DME-446107", "R-HSA-354194", "R-HSA-9679191", "R-MMU-354194", "R-MMU-1236973", "R-HSA-9830674", "R-BTA-9860927", "R-DME-3000170", "R-CEL-4420097", "R-CEL-445355", "R-BTA-216083", "R-HSA-202733", "R-MMU-2129379"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-210990:r:PECAM1 interactions", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-CEL-1566948:r:Elastic fibre formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-445355:r:Smooth Muscle Contraction", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-445355:r:Smooth Muscle Contraction", "R-RNO-3000157:r:Laminin interactions", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-BTA-9634597:r:GPER1 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-3000178:r:ECM proteoglycans", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-210991:r:Basigin interactions", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-8949275:r:RUNX3 Regulates Immune Response and Cell Migration", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-DME-354192:r:Integrin signaling", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-HSA-447041:r:CHL1 interactions", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-445144:r:Signal transduction by L1", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-HSA-3000157:r:Laminin interactions", "R-BTA-1566977:r:Fibronectin matrix formation", "R-CEL-1566977:r:Fibronectin matrix formation", "R-HSA-1566948:r:Elastic fibre formation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-HSA-114608:r:Platelet degranulation", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-445355:r:Smooth Muscle Contraction", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CEL-354192:r:Integrin signaling", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-354192:r:Integrin signaling", "R-MMU-3000157:r:Laminin interactions", "R-BTA-8874081:r:MET activates PTK2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-210991:r:Basigin interactions", "R-HSA-1566977:r:Fibronectin matrix formation", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-DME-446107:r:Type I hemidesmosome assembly", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-9830674:r:Formation of the ureteric bud", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-445355:r:Smooth Muscle Contraction", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR013650": {"description": "ATP-grasp fold, succinyl-CoA synthetase-type", "go_ids": [], "go_terms": [], "name": "ATP-grasp_succ-CoA_synth-type", "pathway_ids": ["PWY-8354", "PWY-8347", "PWY-6728", "PWY-7384", "PWY-5690", "PWY-5537", "PWY-5538", "PWY-5392", "PWY-6969", "R-MMU-9837999", "R-SPO-71403", "R-CEL-9837999", "R-CEL-71403", "R-MMU-71403", "R-BTA-9837999", "R-BTA-71403", "R-SCE-71403", "R-DDI-71403", "R-HSA-9837999", "R-HSA-71403"], "pathways": ["PWY-8354:t:adipate degradation", "PWY-8347:t:adipate biosynthesis", "PWY-6728:t:methylaspartate cycle", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5537:t:pyruvate fermentation to acetate V", "PWY-5538:t:pyruvate fermentation to acetate VI", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Domain"}, "IPR013651": {"description": "ATP-grasp fold, RimK-type", "go_ids": [], "go_terms": [], "name": "ATP-grasp_RimK-type", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565", "R-MMU-8964539", "R-BTA-8964539", "R-HSA-8964539", "R-SCE-1855167", "R-SPO-1855167", "R-DRE-8964539"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-BTA-8964539:r:Glutamate and glutamine metabolism", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-SCE-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-SPO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-DRE-8964539:r:Glutamate and glutamine metabolism"], "type": "Domain"}, "IPR013652": {"description": "Glycine N-acyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "Glycine_N-acyltransferase_C", "pathway_ids": ["R-MMU-177135", "R-HSA-177128", "R-RNO-177135", "R-HSA-9749641", "R-MMU-177128", "R-RNO-9749641", "R-MMU-9749641", "R-HSA-177135", "R-RNO-177128"], "pathways": ["R-MMU-177135:r:Conjugation of benzoate with glycine", "R-HSA-177128:r:Conjugation of salicylate with glycine", "R-RNO-177135:r:Conjugation of benzoate with glycine", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-177128:r:Conjugation of salicylate with glycine", "R-RNO-9749641:r:Aspirin ADME", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-177135:r:Conjugation of benzoate with glycine", "R-RNO-177128:r:Conjugation of salicylate with glycine"], "type": "Domain"}, "IPR013653": {"description": "GCN5-related N-acetyltransferase Rv2170-like domain", "go_ids": ["GO:0016747"], "go_terms": ["GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "GCN5-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013654": {"description": "PAS fold-2", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "PAS_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013655": {"description": "PAS fold 3", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "PAS_fold_3", "pathway_ids": ["R-HSA-1989781", "R-RNO-1234176", "R-HSA-211981", "R-MMU-1234174", "R-RNO-9932298", "R-HSA-9768919", "R-HSA-211945", "R-CEL-211945", "R-HSA-1234174", "R-HSA-1234158", "R-HSA-8951664", "R-HSA-5689880", "R-HSA-9932298", "R-DME-8951664", "R-MMU-8937144", "R-RNO-211981", "R-DME-1234158", "R-MMU-211945", "R-MMU-8951664", "R-MMU-5689880", "R-MMU-211981", "R-MMU-1234158", "R-HSA-9931530", "R-HSA-8849473", "R-RNO-8857538", "R-HSA-2122947", "R-HSA-9701898", "R-HSA-8937144", "R-HSA-1234176", "R-RNO-8937144", "R-RNO-9768919", "R-MMU-9932298", "R-RNO-1234174", "R-HSA-9931521", "R-HSA-6785807", "R-MMU-1234176", "R-RNO-5689880", "R-RNO-211945", "R-HSA-9931510", "R-HSA-9768778", "R-HSA-9909649", "R-MMU-211976", "R-MMU-9768919", "R-RNO-8951664", "R-RNO-1234158", "R-RNO-211976", "R-DME-1234176", "R-CEL-8937144", "R-HSA-211976", "R-MMU-8857538", "R-HSA-8857538"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-211981:r:Xenobiotics", "R-MMU-1234174:r:Cellular response to hypoxia", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-CEL-211945:r:Phase I - Functionalization of compounds", "R-HSA-1234174:r:Cellular response to hypoxia", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-8951664:r:Neddylation", "R-MMU-8937144:r:Aryl hydrocarbon receptor signalling", "R-RNO-211981:r:Xenobiotics", "R-DME-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-211981:r:Xenobiotics", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-HSA-8849473:r:PTK6 Expression", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-8937144:r:Aryl hydrocarbon receptor signalling", "R-RNO-9768919:r:NPAS4 regulates expression of target genes", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-1234174:r:Cellular response to hypoxia", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-211976:r:Endogenous sterols", "R-MMU-9768919:r:NPAS4 regulates expression of target genes", "R-RNO-8951664:r:Neddylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-211976:r:Endogenous sterols", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-211976:r:Endogenous sterols", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Domain"}, "IPR013656": {"description": "PAS fold 4", "go_ids": [], "go_terms": [], "name": "PAS_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013657": {"description": "HUT1", "go_ids": ["GO:0055085"], "go_terms": ["GO:0055085:transmembrane transport:P"], "name": "HUT1", "pathway_ids": ["R-SPO-727802", "R-MMU-174362", "R-DDI-174362", "R-DRE-727802", "R-CEL-727802", "R-DME-727802", "R-HSA-727802", "R-HSA-174362", "R-SCE-727802", "R-DME-174362", "R-DDI-727802", "R-CEL-174362", "R-MMU-727802"], "pathways": ["R-SPO-727802:r:Transport of nucleotide sugars", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-DDI-174362:r:Transport and metabolism of PAPS", "R-DRE-727802:r:Transport of nucleotide sugars", "R-CEL-727802:r:Transport of nucleotide sugars", "R-DME-727802:r:Transport of nucleotide sugars", "R-HSA-727802:r:Transport of nucleotide sugars", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-SCE-727802:r:Transport of nucleotide sugars", "R-DME-174362:r:Transport and metabolism of PAPS", "R-DDI-727802:r:Transport of nucleotide sugars", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-MMU-727802:r:Transport of nucleotide sugars"], "type": "Family"}, "IPR013658": {"description": "SMP-30/Gluconolactonase/LRE-like region", "go_ids": [], "go_terms": [], "name": "SGL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013659": {"description": "Adenosine/AMP deaminase N-terminal", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "A_deaminase_N", "pathway_ids": ["PWY-6611", "PWY-7179", "PWY-6609", "R-DDI-6798695", "R-DRE-5683826", "R-DDI-5683826", "R-HSA-6798695", "R-HSA-5683826", "R-DRE-6798695"], "pathways": ["PWY-6611:t:adenine and adenosine salvage V", "PWY-7179:t:purine deoxyribonucleosides degradation I", "PWY-6609:t:adenine and adenosine salvage III", "R-DDI-6798695:r:Neutrophil degranulation", "R-DRE-5683826:r:Surfactant metabolism", "R-DDI-5683826:r:Surfactant metabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5683826:r:Surfactant metabolism", "R-DRE-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR013660": {"description": "DNA polymerase B exonuclease, N-terminal", "go_ids": ["GO:0003887"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F"], "name": "DNApol_B_exo_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013661": {"description": "Peptidase M9, collagenase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Peptidase_M9_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013662": {"description": "RyR/IP3R Homology associated domain", "go_ids": [], "go_terms": [], "name": "RIH_assoc-dom", "pathway_ids": ["R-MMU-139853", "R-HSA-139853", "R-CEL-983695", "R-HSA-5607763", "R-DDI-139853", "R-HSA-2672351", "R-HSA-1489509", "R-HSA-2029485", "R-DDI-5578775", "R-DME-114508", "R-MMU-418457", "R-MMU-381676", "R-RNO-2672351", "R-HSA-418457", "R-HSA-112043", "R-HSA-114508", "R-MMU-9717207", "R-MMU-2672351", "R-DDI-381676", "R-CEL-114508", "R-CEL-9717207", "R-RNO-139853", "R-DME-139853", "R-RNO-418457", "R-HSA-5578775", "R-HSA-4086398", "R-RNO-114508", "R-DME-381676", "R-MMU-114508", "R-HSA-983695", "R-RNO-9717207", "R-DME-5578775", "R-DDI-9717207", "R-RNO-5578775", "R-CEL-139853", "R-HSA-2871809", "R-MMU-5578775", "R-DME-983695", "R-DME-9717207", "R-MMU-983695", "R-RNO-381676", "R-CEL-381676", "R-HSA-5218921", "R-HSA-9717207", "R-CEL-5578775", "R-HSA-381676", "R-RNO-983695", "R-DDI-114508", "R-HSA-9664323", "R-HSA-422356"], "pathways": ["R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-CEL-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DDI-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-1489509:r:DAG and IP3 signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-5578775:r:Ion homeostasis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-MMU-418457:r:cGMP effects", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-418457:r:cGMP effects", "R-HSA-112043:r:PLC beta mediated events", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-MMU-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-CEL-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-DME-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-418457:r:cGMP effects", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-4086398:r:Ca2+ pathway", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-DME-5578775:r:Ion homeostasis", "R-DDI-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-5578775:r:Ion homeostasis", "R-CEL-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5578775:r:Ion homeostasis", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-5578775:r:Ion homeostasis", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR013663": {"description": "Helicase, SWF/SNF/SWI type, bacterial", "go_ids": [], "go_terms": [], "name": "Helicase_SWF/SNF/SWI_bac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013664": {"description": "Viral methyltransferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Virgavirus_MeTrfase_C", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-7706", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-7529", "PWY-5479", "PWY-6322", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-7904", "PWY-6736", "PWY-6998", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7888", "PWY-7155", "PWY-7719", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-7419", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-6749", "PWY-7668", "PWY-8179", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-7769", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-7127", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-6626", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-8117", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR013665": {"description": "Sfi1 spindle body", "go_ids": [], "go_terms": [], "name": "Sfi1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013666": {"description": "Pleckstrin-like, plant", "go_ids": [], "go_terms": [], "name": "PH_pln", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013668": {"description": "Ribonuclease R winged-helix domain", "go_ids": [], "go_terms": [], "name": "RNase_R_HTH_12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013669": {"description": "Coat protein, C-terminal, Carmoviral", "go_ids": [], "go_terms": [], "name": "Coat_prot_C_Carmovir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013670": {"description": "EcoEI R protein C-terminal domain", "go_ids": ["GO:0003677", "GO:0003824", "GO:0006304"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003824:catalytic activity:F", "GO:0006304:DNA modification:P"], "name": "EcoEI_R_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013671": {"description": "Geminivirus AC4/5, conserved domain", "go_ids": [], "go_terms": [], "name": "Gemini_AC4/5_cons-dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013672": {"description": "Herpesvirus thymidine kinase, C-terminal", "go_ids": ["GO:0004797", "GO:0005524"], "go_terms": ["GO:0004797:thymidine kinase activity:F", "GO:0005524:ATP binding:F"], "name": "Herpes_TK_C", "pathway_ids": ["PWY-7199"], "pathways": ["PWY-7199:t:pyrimidine deoxyribonucleosides salvage"], "type": "Domain"}, "IPR013673": {"description": "Potassium channel, inwardly rectifying, Kir, N-terminal", "go_ids": [], "go_terms": [], "name": "K_chnl_inward-rec_Kir_N", "pathway_ids": ["R-SSC-5576886", "R-RNO-997272", "R-HSA-1296053", "R-SSC-1296053", "R-RNO-1296053", "R-HSA-5576886", "R-MMU-5576886", "R-CFA-5576886", "R-GGA-5576886", "R-MMU-1296041", "R-RNO-1296041", "R-RNO-5576886", "R-BTA-1296053", "R-MMU-1296053", "R-BTA-1296041", "R-HSA-9729555", "R-GGA-1296053", "R-GGA-997272", "R-CFA-1296053", "R-MMU-997272", "R-HSA-1296041", "R-BTA-5576886", "R-SSC-1296041", "R-GGA-1296041", "R-BTA-997272", "R-SSC-997272", "R-HSA-997272", "R-CFA-1296041", "R-CFA-997272"], "pathways": ["R-SSC-5576886:r:Phase 4 - resting membrane potential", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296053:r:Classical Kir channels", "R-SSC-1296053:r:Classical Kir channels", "R-RNO-1296053:r:Classical Kir channels", "R-HSA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-5576886:r:Phase 4 - resting membrane potential", "R-CFA-5576886:r:Phase 4 - resting membrane potential", "R-GGA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-5576886:r:Phase 4 - resting membrane potential", "R-BTA-1296053:r:Classical Kir channels", "R-MMU-1296053:r:Classical Kir channels", "R-BTA-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-9729555:r:Sensory perception of sour taste", "R-GGA-1296053:r:Classical Kir channels", "R-GGA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CFA-1296053:r:Classical Kir channels", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-BTA-5576886:r:Phase 4 - resting membrane potential", "R-SSC-1296041:r:Activation of G protein gated Potassium channels", "R-GGA-1296041:r:Activation of G protein gated Potassium channels", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-SSC-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CFA-1296041:r:Activation of G protein gated Potassium channels", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "type": "Domain"}, "IPR013674": {"description": "Luteovirus RNA polymerase P1-P2/replicase", "go_ids": ["GO:0003968"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F"], "name": "Luteo_Rpol_P1-P2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013675": {"description": "Methyltransferase small, N-terminal", "go_ids": ["GO:0006364", "GO:0008990"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0008990:rRNA (guanine-N2-)-methyltransferase activity:F"], "name": "Mtase_sm_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013676": {"description": "Nucleoside triphosphatase I, C-terminal", "go_ids": ["GO:0005524", "GO:0006351", "GO:0017111"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006351:DNA-templated transcription:P", "GO:0017111:ribonucleoside triphosphate phosphatase activity:F"], "name": "NPHI_C", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR013677": {"description": "Non-toxic nonhaemagglutinin, C-terminal", "go_ids": [], "go_terms": [], "name": "NTNH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013678": {"description": "Ribonucleotide reductase class II vitamin B12-dependent, N-terminal domain", "go_ids": ["GO:0004748", "GO:0050897"], "go_terms": ["GO:0004748:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor:F", "GO:0050897:cobalt ion binding:F"], "name": "RNR_2_N", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR013679": {"description": "Sucrose-phosphatase, C-terminal", "go_ids": ["GO:0005986", "GO:0050307"], "go_terms": ["GO:0005986:sucrose biosynthetic process:P", "GO:0050307:sucrose-phosphate phosphatase activity:F"], "name": "SPP_C", "pathway_ids": ["PWY-7238", "PWY-7347"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-7347:t:sucrose biosynthesis III"], "type": "Domain"}, "IPR013680": {"description": "Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region", "go_ids": [], "go_terms": [], "name": "VDCC_a2/dsu", "pathway_ids": ["R-RNO-422356", "R-MMU-5576893", "R-RNO-5576893", "R-HSA-5576893", "R-HSA-9662360", "R-MMU-422356", "R-RNO-112308", "R-MMU-5576892", "R-HSA-422356", "R-HSA-400042", "R-HSA-9856532", "R-HSA-112308", "R-MMU-112308", "R-HSA-5576892", "R-RNO-5576892"], "pathways": ["R-RNO-422356:r:Regulation of insulin secretion", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-422356:r:Regulation of insulin secretion", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-RNO-5576892:r:Phase 0 - rapid depolarisation"], "type": "Domain"}, "IPR013681": {"description": "Myelin transcription factor 1", "go_ids": [], "go_terms": [], "name": "Myelin_TF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013682": {"description": "Baculovirus Vp91, capsid protein, N-terminal", "go_ids": [], "go_terms": [], "name": "BaculoV_Vp91_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013683": {"description": "Vaccinia virus D10, N-terminal", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "Vaccinia_D10_N", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Domain"}, "IPR013685": {"description": "POTRA domain, FtsQ-type", "go_ids": [], "go_terms": [], "name": "POTRA_FtsQ_type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013686": {"description": "Polypeptide-transport-associated, ShlB-type", "go_ids": [], "go_terms": [], "name": "Polypept-transport_assoc_ShlB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013687": {"description": "Disaggregatase-related", "go_ids": [], "go_terms": [], "name": "Disaggr-rel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013688": {"description": "GBS Bsp-like", "go_ids": [], "go_terms": [], "name": "GBS_Bsp-like", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR013689": {"description": "ATP-dependent RNA helicase HrpB, C-terminal", "go_ids": [], "go_terms": [], "name": "RNA_helicase_ATP-dep_HrpB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013691": {"description": "C-methyltransferase", "go_ids": [], "go_terms": [], "name": "MeTrfase_14", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013692": {"description": "UDP-glucose 4-epimerase CapD, C-terminal domain", "go_ids": ["GO:0003978", "GO:0009103"], "go_terms": ["GO:0003978:UDP-glucose 4-epimerase activity:F", "GO:0009103:lipopolysaccharide biosynthetic process:P"], "name": "CapD_C", "pathway_ids": ["PWY-6527", "PWY-7328", "PWY-3821", "PWY-6397", "PWY-7344", "PWY-6317"], "pathways": ["PWY-6527:t:stachyose degradation", "PWY-7328:t:superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis", "PWY-3821:t:D-galactose detoxification", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-7344:t:UDP-alpha-D-galactose biosynthesis", "PWY-6317:t:D-galactose degradation I (Leloir pathway)"], "type": "Domain"}, "IPR013693": {"description": "Sporulation stage II protein D, amidase enhancer LytB N-terminal", "go_ids": [], "go_terms": [], "name": "SpoIID/LytB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013694": {"description": "VIT domain", "go_ids": [], "go_terms": [], "name": "VIT", "pathway_ids": ["R-HSA-114608", "R-BTA-114608", "R-SSC-381426", "R-SSC-8957275", "R-MMU-381426", "R-HSA-9683610", "R-HSA-196807", "R-HSA-8957275", "R-HSA-9694631", "R-MMU-8957275", "R-HSA-381426", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR013695": {"description": "Wall-associated receptor kinase", "go_ids": ["GO:0004674", "GO:0016020"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0016020:membrane:C"], "name": "WAK", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013696": {"description": "TiaS, FLD domain", "go_ids": [], "go_terms": [], "name": "TiaS_FLD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013697": {"description": "DNA polymerase epsilon, catalytic subunit A, C-terminal", "go_ids": ["GO:0003887", "GO:0005634", "GO:0006260", "GO:0008270"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0005634:nucleus:C", "GO:0006260:DNA replication:P", "GO:0008270:zinc ion binding:F"], "name": "DNA_pol_e_suA_C", "pathway_ids": ["R-DDI-6782135", "R-DME-110314", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656169", "R-HSA-5696397", "R-DDI-6782210", "R-MMU-110314", "R-DDI-68952", "R-DME-68962", "R-DDI-68962", "R-HSA-68962", "R-HSA-6782210", "R-DME-68952", "R-HSA-5656169", "R-DME-6782135", "R-SCE-68952", "R-MMU-5696400", "R-SPO-5696397", "R-DME-5651801", "R-HSA-68952", "R-MMU-68962", "R-MMU-5651801", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-SCE-68962", "R-MMU-68952", "R-DME-5656169", "R-SPO-5696400", "R-SPO-68952", "R-DME-5696400", "R-SPO-6782210", "R-SPO-110314", "R-SPO-68962", "R-HSA-5696400", "R-HSA-110314", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-SCE-6782135", "R-SPO-5651801"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-68952:r:DNA replication initiation", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-68952:r:DNA replication initiation", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-68952:r:DNA replication initiation", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-MMU-68952:r:DNA replication initiation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-68952:r:DNA replication initiation", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Domain"}, "IPR013698": {"description": "Squalene epoxidase", "go_ids": ["GO:0004506", "GO:0016020", "GO:0050660"], "go_terms": ["GO:0004506:squalene monooxygenase activity:F", "GO:0016020:membrane:C", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "Squalene_epoxidase", "pathway_ids": ["PWY-5670", "R-SCE-9969896", "R-HSA-9969896", "R-MMU-9969896", "R-HSA-2426168", "R-RNO-9969896", "R-SPO-9969896"], "pathways": ["PWY-5670:t:epoxysqualene biosynthesis", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR013699": {"description": "Signal recognition particle, SRP72 subunit, RNA-binding", "go_ids": ["GO:0006614", "GO:0008312", "GO:0048500"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P", "GO:0008312:7S RNA binding:F", "GO:0048500:signal recognition particle:C"], "name": "Signal_recog_part_SRP72_RNA-bd", "pathway_ids": ["R-HSA-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-CEL-1799339", "R-SPO-1799339", "R-SCE-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Domain"}, "IPR013700": {"description": "Aflatoxin regulatory protein", "go_ids": ["GO:0003677", "GO:0005634", "GO:0045122", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0045122:aflatoxin biosynthetic process:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "AflR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013701": {"description": "Lhr-like, DEAD/H associated domain", "go_ids": ["GO:0005524", "GO:0016818"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F"], "name": "Lhr-like_DEAD/DEAH_assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013702": {"description": "FIST domain, N-terminal", "go_ids": [], "go_terms": [], "name": "FIST_domain_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013703": {"description": "Peptidase S49, N-terminal proteobacteria", "go_ids": ["GO:0004252", "GO:0005886"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0005886:plasma membrane:C"], "name": "Peptidase_S49_N_proteobac", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR013704": {"description": "UPF0313, N-terminal", "go_ids": [], "go_terms": [], "name": "UPF0313_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013705": {"description": "Sterol methyltransferase C-terminal", "go_ids": ["GO:0006694", "GO:0008168"], "go_terms": ["GO:0006694:steroid biosynthetic process:P", "GO:0008168:methyltransferase activity:F"], "name": "Sterol_MeTrfase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013706": {"description": "PDE1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PDE1_N", "pathway_ids": ["R-RNO-418555", "R-CEL-111957", "R-DME-418555", "R-DME-111957", "R-CEL-418457", "R-HSA-418555", "R-BTA-111957", "R-MMU-418457", "R-MMU-111957", "R-BTA-418457", "R-CEL-418555", "R-HSA-418457", "R-DME-418457", "R-BTA-418555", "R-RNO-418457", "R-RNO-111957", "R-HSA-111957", "R-MMU-418555"], "pathways": ["R-RNO-418555:r:G alpha (s) signalling events", "R-CEL-111957:r:Cam-PDE 1 activation", "R-DME-418555:r:G alpha (s) signalling events", "R-DME-111957:r:Cam-PDE 1 activation", "R-CEL-418457:r:cGMP effects", "R-HSA-418555:r:G alpha (s) signalling events", "R-BTA-111957:r:Cam-PDE 1 activation", "R-MMU-418457:r:cGMP effects", "R-MMU-111957:r:Cam-PDE 1 activation", "R-BTA-418457:r:cGMP effects", "R-CEL-418555:r:G alpha (s) signalling events", "R-HSA-418457:r:cGMP effects", "R-DME-418457:r:cGMP effects", "R-BTA-418555:r:G alpha (s) signalling events", "R-RNO-418457:r:cGMP effects", "R-RNO-111957:r:Cam-PDE 1 activation", "R-HSA-111957:r:Cam-PDE 1 activation", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Domain"}, "IPR013707": {"description": "Tombusvirus p33", "go_ids": ["GO:0003968"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F"], "name": "Tombusvirus_p33", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013708": {"description": "Shikimate dehydrogenase substrate binding, N-terminal", "go_ids": ["GO:0004764"], "go_terms": ["GO:0004764:shikimate 3-dehydrogenase (NADP+) activity:F"], "name": "Shikimate_DH-bd_N", "pathway_ids": ["PWY-6163"], "pathways": ["PWY-6163:t:chorismate biosynthesis from 3-dehydroquinate"], "type": "Domain"}, "IPR013709": {"description": "2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain", "go_ids": ["GO:0003852", "GO:0009098"], "go_terms": ["GO:0003852:2-isopropylmalate synthase activity:F", "GO:0009098:L-leucine biosynthetic process:P"], "name": "2-isopropylmalate_synth_dimer", "pathway_ids": ["PWY-6871"], "pathways": ["PWY-6871:t:3-methylbutanol biosynthesis (engineered)"], "type": "Domain"}, "IPR013710": {"description": "2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, N-terminal", "go_ids": ["GO:0047200"], "go_terms": ["GO:0047200:tetrahydrodipicolinate N-acetyltransferase activity:F"], "name": "DapH_N", "pathway_ids": ["PWY-2941"], "pathways": ["PWY-2941:t:L-lysine biosynthesis II"], "type": "Domain"}, "IPR013711": {"description": "Runx, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RunxI_C_dom", "pathway_ids": ["R-HSA-2032785", "R-MMU-8941326", "R-HSA-8939256", "R-HSA-9942503", "R-HSA-8941856", "R-HSA-8951430", "R-MMU-8941858", "R-HSA-8936459", "R-MMU-8940973", "R-RNO-8934593", "R-MMU-8951671", "R-MMU-8939246", "R-HSA-8951911", "R-MMU-8939247", "R-MMU-8934593", "R-HSA-8952158", "R-MMU-8939245", "R-RNO-8939246", "R-RNO-8939243", "R-RNO-8936459", "R-RNO-9018519", "R-MMU-8939236", "R-HSA-1912408", "R-HSA-8939236", "R-HSA-8941333", "R-HSA-8939245", "R-HSA-8877330", "R-RNO-8939245", "R-HSA-8941855", "R-RNO-549127", "R-HSA-9616222", "R-HSA-8878166", "R-MMU-8877330", "R-RNO-8939247", "R-MMU-8951430", "R-HSA-8941326", "R-HSA-9018519", "R-MMU-8941855", "R-HSA-8951936", "R-MMU-8931987", "R-MMU-8936459", "R-HSA-8939247", "R-HSA-8931987", "R-MMU-8951936", "R-HSA-8951671", "R-HSA-8941858", "R-HSA-8949275", "R-RNO-8931987", "R-HSA-8934593", "R-MMU-8878166", "R-MMU-8939243", "R-HSA-8941332", "R-MMU-9018519", "R-RNO-8939236", "R-HSA-8939902", "R-HSA-8939243", "R-HSA-8935964", "R-RNO-8877330", "R-MMU-8939902", "R-HSA-9692916", "R-MMU-8941856", "R-HSA-549127", "R-HSA-4411364", "R-HSA-8939246", "R-MMU-549127", "R-HSA-8939242", "R-HSA-8940973", "R-HSA-8941284"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-8941326:r:RUNX2 regulates bone development", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-8951430:r:RUNX3 regulates WNT signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-8940973:r:RUNX2 regulates osteoblast differentiation", "R-RNO-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-8951911:r:RUNX3 regulates RUNX1-mediated transcription", "R-MMU-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8941333:r:RUNX2 regulates genes involved in differentiation of myeloid cells", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-549127:r:SLC-mediated transport of organic cations", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-MMU-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-MMU-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-8949275:r:RUNX3 Regulates Immune Response and Cell Migration", "R-RNO-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-RNO-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-549127:r:SLC-mediated transport of organic cations", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation"], "type": "Domain"}, "IPR013712": {"description": "Mitochondrial Myo2 receptor-related protein 1", "go_ids": [], "go_terms": [], "name": "MMR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013713": {"description": "Exportin-2, central domain", "go_ids": ["GO:0006886"], "go_terms": ["GO:0006886:intracellular protein transport:P"], "name": "XPO2_central", "pathway_ids": ["R-SPO-5578749", "R-HSA-5578749", "R-HSA-9918432", "R-MMU-5578749"], "pathways": ["R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-9918432:r:Maturation of DENV proteins", "R-MMU-5578749:r:Transcriptional regulation by small RNAs"], "type": "Domain"}, "IPR013714": {"description": "Golgi apparatus membrane protein TVP15", "go_ids": [], "go_terms": [], "name": "Golgi_TVP15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013715": {"description": "Domain of unknown function DUF1746", "go_ids": [], "go_terms": [], "name": "DUF1746", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013716": {"description": "Adenylate cyclase G-alpha binding", "go_ids": ["GO:0000287", "GO:0004016", "GO:0006171"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0004016:adenylate cyclase activity:F", "GO:0006171:cAMP biosynthetic process:P"], "name": "Adenylate_cyclase_G-a-bd", "pathway_ids": ["R-SPO-9013106", "R-SPO-8980692", "R-SPO-9652282", "R-SPO-983168", "R-SPO-6803207", "R-SPO-5223345", "R-SPO-199418"], "pathways": ["R-SPO-9013106:r:RHOC GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-SPO-5223345:r:Miscellaneous transport and binding events", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network"], "type": "Domain"}, "IPR013717": {"description": "PIG-P", "go_ids": [], "go_terms": [], "name": "PIG-P", "pathway_ids": ["R-HSA-162710", "R-SPO-162710", "R-MMU-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Domain"}, "IPR013718": {"description": "COQ9, C-terminal domain", "go_ids": [], "go_terms": [], "name": "COQ9_C", "pathway_ids": ["R-SPO-2142789", "R-SCE-2142789", "R-DDI-2142789", "R-HSA-2142789", "R-BTA-2142789", "R-RNO-2142789", "R-MMU-2142789", "R-DME-2142789", "R-XTR-2142789"], "pathways": ["R-SPO-2142789:r:Ubiquinol biosynthesis", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-BTA-2142789:r:Ubiquinol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis", "R-XTR-2142789:r:Ubiquinol biosynthesis"], "type": "Domain"}, "IPR013719": {"description": 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of Tat-mediated HIV elongation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR013721": {"description": "STAG", "go_ids": [], "go_terms": [], "name": "STAG", "pathway_ids": ["R-SCE-3108214", "R-HSA-2468052", "R-MMU-2500257", "R-SPO-2500257", "R-SCE-2468052", "R-SPO-3108214", "R-SPO-2470946", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-3108214", "R-MMU-2467813", "R-CEL-2470946", "R-HSA-2470946", "R-HSA-1221632", "R-SCE-2500257", "R-CEL-3108214", "R-MMU-3108214", "R-CEL-2468052", "R-MMU-2468052", "R-MMU-2470946", "R-HSA-9018519", "R-CEL-2500257"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-1221632:r:Meiotic synapsis", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion"], "type": "Domain"}, "IPR013724": {"description": "GIT, Spa2 homology (SHD) domain", "go_ids": [], "go_terms": [], "name": "GIT_SHD", "pathway_ids": ["R-HSA-9013409", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-DME-9013424", "R-HSA-9013423", "R-MMU-9013420", "R-RNO-9013424", "R-HSA-9013148", "R-DME-9013406", "R-DME-3928664", "R-HSA-9619229", "R-RNO-9013404", "R-RNO-9013406", "R-MMU-3928664", "R-DME-9013149", "R-HSA-9013420", "R-HSA-3928664", "R-MMU-9013424", "R-RNO-9013420", "R-RNO-3928664", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-9013423", "R-HSA-9013149", "R-MMU-9013406", "R-HSA-9013406", "R-MMU-9013149", "R-DME-9013423", "R-DME-9013420"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-3928664:r:Ephrin signaling", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-3928664:r:Ephrin signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR013725": {"description": "DNA replication factor RFC1, C-terminal", "go_ids": ["GO:0003689", "GO:0005524", "GO:0005663", "GO:0006260"], "go_terms": ["GO:0003689:DNA clamp loader activity:F", "GO:0005524:ATP binding:F", "GO:0005663:DNA replication factor C complex:C", "GO:0006260:DNA replication:P"], "name": "DNA_replication_fac_RFC1_C", "pathway_ids": ["R-DDI-6782135", "R-DME-110314", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656169", "R-SPO-5655862", "R-SPO-5656121", "R-SCE-69091", "R-HSA-5696397", "R-MMU-110320", "R-MMU-110312", "R-SPO-110312", "R-DME-5656121", "R-DDI-6782210", "R-HSA-5655862", "R-DME-5696397", "R-MMU-110314", "R-SCE-6782135", "R-SPO-69091", "R-DME-5655862", "R-DME-110312", "R-HSA-6782210", "R-HSA-5656121", "R-SCE-6782210", "R-HSA-5656169", "R-DME-6782135", "R-MMU-5696400", "R-MMU-5655862", "R-SPO-5696397", "R-DME-5651801", "R-DDI-69091", "R-MMU-5651801", "R-DME-110320", "R-MMU-5656169", "R-DME-69091", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-HSA-110312", "R-HSA-174411", "R-DME-5656169", "R-MMU-5656121", "R-SPO-5696400", "R-DME-5696400", "R-SPO-110320", "R-SPO-110314", "R-SPO-6782210", "R-HSA-5696400", "R-HSA-69091", "R-DME-6782210", "R-SPO-6782135", "R-MMU-6782210", "R-MMU-5696397", "R-MMU-174411", "R-HSA-110320", "R-MMU-69091", "R-HSA-110314", "R-SPO-5651801"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SCE-69091:r:Polymerase switching", "R-HSA-5696397:r:Gap-filling 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"R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-69091:r:Polymerase switching", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DME-110320:r:Translesion Synthesis by POLH", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-DME-69091:r:Polymerase switching", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110312:r:Translesion synthesis by REV1", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-69091:r:Polymerase switching", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-MMU-69091:r:Polymerase switching", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Domain"}, "IPR013726": {"description": "Mitofissin", "go_ids": [], "go_terms": [], "name": "Mitofissin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013727": {"description": "Two-component sensor kinase, N-terminal", "go_ids": [], "go_terms": [], "name": "2CSK_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013728": {"description": "BT_3987-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BT_3987-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013729": {"description": "Multiprotein bridging factor 1, N-terminal", "go_ids": [], "go_terms": [], "name": "MBF1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013730": {"description": "Fyv7/TAP26", "go_ids": [], "go_terms": [], "name": "Fyv7/TAP26", "pathway_ids": ["R-HSA-5683826", "R-DRE-5683826", "R-BTA-5683826", "R-MMU-5683826"], "pathways": ["R-HSA-5683826:r:Surfactant metabolism", "R-DRE-5683826:r:Surfactant metabolism", "R-BTA-5683826:r:Surfactant metabolism", "R-MMU-5683826:r:Surfactant metabolism"], "type": "Family"}, "IPR013731": {"description": "Opacity-associated protein A-like, N-terminal", "go_ids": [], "go_terms": [], "name": "OapA_N", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR013732": {"description": "Protein-arginine deiminase (PAD), N-terminal", "go_ids": ["GO:0005509", "GO:0005737"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0005737:cytoplasm:C"], "name": "PAD_N", "pathway_ids": ["PWY-4921", "R-MMU-6798695", "R-HSA-6798695", "R-RNO-3247509", "R-RNO-6798695", "R-MMU-3247509", "R-HSA-3247509"], "pathways": ["PWY-4921:t:protein citrullination", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-HSA-3247509:r:Chromatin modifying enzymes"], "type": "Domain"}, "IPR013733": {"description": "Protein-arginine deiminase (PAD), central domain", "go_ids": ["GO:0005509", "GO:0005737"], "go_terms": ["GO:0005509:calcium ion binding:F", 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"pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013736": {"description": "Xaa-Pro dipeptidyl-peptidase, C-terminal", "go_ids": ["GO:0008239"], "go_terms": ["GO:0008239:dipeptidyl-peptidase activity:F"], "name": "Xaa-Pro_dipept_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013737": {"description": "Bacterial alpha-L-rhamnosidase N-terminal", "go_ids": [], "go_terms": [], "name": "Bac_rhamnosid_N", "pathway_ids": ["PWY-7134"], "pathways": ["PWY-7134:t:rutin degradation (plants)"], "type": "Domain"}, "IPR013738": {"description": "Beta-galactosidase trimerisation", "go_ids": ["GO:0004565", "GO:0005975"], "go_terms": ["GO:0004565:beta-galactosidase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Beta_galactosidase_Trimer", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR013739": {"description": "Beta-galactosidase C-terminal", "go_ids": ["GO:0004565", "GO:0006012"], "go_terms": ["GO:0004565:beta-galactosidase activity:F", "GO:0006012:galactose metabolic process:P"], "name": "Beta_galactosidase_C", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR013740": {"description": "Redoxin", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Redoxin", "pathway_ids": ["R-HSA-3299685", "R-HSA-1222538", "R-BTA-3299685", "R-HSA-1222541", "R-MMU-5628897", "R-RNO-5628897", "R-MMU-3299685", "R-HSA-5628897", "R-RNO-3299685", "R-BTA-5628897"], "pathways": ["R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1222541:r:Cell redox homeostasis", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Domain"}, "IPR013741": {"description": "Repressor KorB domain", "go_ids": [], "go_terms": [], "name": "KorB_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013742": {"description": "Whirly transcription factor", "go_ids": ["GO:0003697", "GO:0006355", "GO:0006952"], "go_terms": ["GO:0003697:single-stranded DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0006952:defense response:P"], "name": "Whirly", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013743": {"description": "NBP1/CSA1", "go_ids": [], "go_terms": [], "name": "NBP1/CSA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013744": {"description": "Fusarinine C esterase SidJ", "go_ids": [], "go_terms": [], "name": "SidJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013745": {"description": "TORC2 component Bit61/PRR5", "go_ids": [], "go_terms": [], "name": "Bit61/PRR5", "pathway_ids": ["R-MMU-9856530", "R-SPO-6804757", "R-HSA-5674400", "R-MMU-5218920", "R-RNO-1257604", "R-SPO-389357", "R-MMU-6804757", "R-SPO-5218920", "R-MMU-1257604", "R-SCE-389357", "R-RNO-5218920", "R-RNO-9856530", "R-SCE-9856530", "R-RNO-6804757", "R-MMU-389357", "R-HSA-5218920", "R-SCE-6804757", "R-HSA-6804757", "R-HSA-389357", "R-SCE-1257604", "R-HSA-9920951", "R-HSA-9856530", "R-HSA-1257604", "R-SPO-1257604", "R-SPO-9856530", "R-SCE-5218920", "R-RNO-389357"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and 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"R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-RNO-110312:r:Translesion synthesis by REV1", "R-CEL-69091:r:Polymerase switching", "R-CEL-176187:r:Activation of ATR in response to replication stress", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SCE-69091:r:Polymerase switching", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-DME-5656121:r:Translesion synthesis by POLI", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-SPO-69091:r:Polymerase switching", "R-GGA-6782135:r:Dual incision in TC-NER", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-CEL-110312:r:Translesion synthesis by REV1", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER"], "type": "Domain"}, "IPR013749": {"description": "Pyridoxamine kinase/Phosphomethylpyrimidine kinase", "go_ids": [], "go_terms": [], "name": "PM/HMP-P_kinase-1", "pathway_ids": ["PWY-7204", "PWY-7282", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-BTA-964975", "R-RNO-964975", "R-HSA-964975", "R-MMU-964975", "R-SCE-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-DDI-964975", "R-SCE-964975", "R-RNO-6798695", "R-SPO-964975"], "pathways": ["PWY-7204:t:pyridoxal 5'-phosphate salvage II (plants)", "PWY-7282:t:4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-SCE-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-6798695:r:Neutrophil degranulation", "R-SPO-964975:r:Vitamin B6 activation to pyridoxal phosphate"], "type": "Domain"}, "IPR013750": {"description": "GHMP kinase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GHMP_kinase_C_dom", "pathway_ids": ["R-HSA-5609976", "R-MMU-70370", "R-BTA-70370", "R-RNO-9969896", "R-HSA-70370", "R-BTA-9969896", "R-DDI-9969896", "R-MMU-6787639", "R-MMU-9969896", "R-CFA-70370", "R-HSA-2426168", "R-HSA-6787639", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["R-HSA-5609976:r:Defective GALK1 causes GALCT2", "R-MMU-70370:r:Galactose catabolism", "R-BTA-70370:r:Galactose catabolism", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-70370:r:Galactose catabolism", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-6787639:r:GDP-fucose biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-CFA-70370:r:Galactose catabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-6787639:r:GDP-fucose biosynthesis", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR013751": {"description": "Beta-ketoacyl-[acyl-carrier-protein] synthase III, N-terminal", "go_ids": ["GO:0004315", "GO:0006633"], "go_terms": ["GO:0004315:3-oxoacyl-[acyl-carrier-protein] synthase activity:F", "GO:0006633:fatty acid biosynthetic process:P"], "name": "ACP_syn_III_N", "pathway_ids": ["PWY-4381"], "pathways": ["PWY-4381:t:fatty acid biosynthesis initiation (type II)"], "type": "Domain"}, "IPR013752": {"description": "Ketopantoate reductase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "KPR_C", "pathway_ids": ["PWY-6654"], "pathways": ["PWY-6654:t:phosphopantothenate biosynthesis III (archaea)"], "type": "Domain"}, "IPR013755": {"description": "Flaviviral glycoprotein E, central domain, subdomain 1", "go_ids": [], "go_terms": [], "name": "Flav_gly_cen_dom_subdom1", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Homologous_superfamily"}, "IPR013756": {"description": "Flaviviral glycoprotein E, central domain, subdomain 2", "go_ids": [], "go_terms": [], "name": "GlyE_cen_dom_subdom2", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Homologous_superfamily"}, "IPR013757": {"description": "DNA topoisomerase, type IIA, alpha-helical domain superfamily", "go_ids": ["GO:0003677", "GO:0003918", "GO:0005524"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F", "GO:0005524:ATP binding:F"], "name": "Topo_IIA_A_a_sf", "pathway_ids": ["R-HSA-9913143", "R-RNO-4615885", "R-HSA-9638771", "R-SCE-4615885", "R-SPO-4615885", "R-HSA-1362277", "R-DME-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9638771:r:Action of antimicrobials", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Homologous_superfamily"}, "IPR013758": {"description": "DNA topoisomerase, type IIA, domain A, alpha-beta", "go_ids": ["GO:0003677", "GO:0003918", "GO:0005524", "GO:0006259", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F", "GO:0005524:ATP binding:F", "GO:0006259:DNA metabolic process:P", "GO:0006265:DNA topological change:P"], "name": "Topo_IIA_A/C_ab", "pathway_ids": ["R-HSA-9913143", "R-RNO-4615885", "R-HSA-9638771", "R-SCE-4615885", "R-SPO-4615885", "R-HSA-1362277", "R-DME-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9638771:r:Action of antimicrobials", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Homologous_superfamily"}, "IPR013759": {"description": "DNA topoisomerase, type IIA, subunit B, C-terminal", "go_ids": ["GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F", "GO:0005524:ATP binding:F", "GO:0006265:DNA topological change:P"], "name": "Topo_IIA_B_C", "pathway_ids": ["R-HSA-9913143", "R-RNO-4615885", "R-HSA-9638771", "R-SCE-4615885", "R-SPO-4615885", "R-HSA-1362277", "R-DME-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9638771:r:Action of antimicrobials", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Homologous_superfamily"}, "IPR013760": {"description": "DNA topoisomerase, type IIA-like domain superfamily", "go_ids": ["GO:0003918", "GO:0005524"], "go_terms": ["GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F", "GO:0005524:ATP binding:F"], "name": "Topo_IIA-like_dom_sf", "pathway_ids": ["R-HSA-9913143", "R-RNO-4615885", "R-HSA-9638771", "R-SCE-4615885", "R-SPO-4615885", "R-HSA-1362277", "R-DME-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9638771:r:Action of antimicrobials", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Homologous_superfamily"}, "IPR013761": {"description": "Sterile alpha motif/pointed domain superfamily", "go_ids": [], "go_terms": [], "name": "SAM/pointed_sf", "pathway_ids": ["R-HSA-4655427", "R-RNO-9013026", "R-HSA-2559580", "R-CEL-181430", "R-HSA-6802952", "R-MMU-3928665", "R-HSA-2871796", "R-MMU-4570464", "R-MMU-181430", "R-MMU-8948751", "R-DME-8948751", "R-DME-2559585", "R-DRE-3928664", "R-MMU-5689880", "R-HSA-9662360", "R-HSA-4570464", "R-HSA-937041", "R-HSA-9696273", "R-HSA-6802955", "R-HSA-170984", "R-DME-4641257", "R-HSA-6802948", "R-HSA-983695", "R-BTA-2559585", "R-MMU-5673000", "R-MMU-201681", "R-RNO-9013148", "R-RNO-936964", "R-CEL-5674135", "R-CEL-212676", "R-MMU-2151201", "R-RNO-6804760", "R-RNO-6804759", "R-BTA-8956319", "R-MMU-912526", "R-DDI-5674135", "R-HSA-909733", "R-HSA-1855204", "R-RNO-388844", "R-MMU-9696264", "R-MMU-3108214", "R-HSA-9680350", "R-HSA-201681", "R-MMU-5674135", "R-HSA-168164", "R-DME-432553", "R-HSA-202433", "R-DRE-2559580", "R-RNO-937072", "R-DRE-3928662", "R-RNO-8980692", "R-HSA-5620971", "R-CEL-210500", "R-DRE-8953750", "R-HSA-6803205", "R-DDI-5674499", "R-MMU-166166", "R-HSA-9824272", "R-DRE-8939243", "R-DRE-4570464", "R-HSA-388844", "R-DME-2151201", "R-DME-4570464", "R-DDI-69601", "R-HSA-9013148", "R-RNO-3928662", "R-RNO-5674135", "R-DDI-5689880", "R-MMU-936964", "R-RNO-937041", "R-MMU-114508", "R-PFA-430116", "R-HSA-9696270", "R-HSA-6803207", "R-MMU-3899300", "R-DME-5578775", "R-RNO-210500", "R-DRE-6809371", "R-HSA-2871809", "R-MMU-9013424", "R-MMU-210500", "R-DDI-5675221", "R-RNO-3928664", "R-HSA-3928665", "R-RNO-983695", "R-MMU-9696273", "R-MMU-937041", "R-HSA-9725370", "R-MMU-1660661", "R-HSA-8849469", "R-HSA-2151201", "R-MMU-9013106", "R-CFA-1660499", "R-HSA-936964", "R-HSA-139915", "R-RNO-912526", "R-DDI-5675482", "R-DDI-170968", "R-RNO-212676", "R-RNO-3928665", "R-HSA-8943724", "R-HSA-9013408", "R-GGA-8956319", "R-HSA-3928664", "R-RNO-3928663", "R-HSA-264642", "R-HSA-9673768", "R-MMU-2559580", "R-HSA-204005", "R-HSA-8939243", "R-MMU-6809371", "R-MMU-4641257", "R-MMU-9013406", "R-RNO-6794361", "R-DME-8943724", "R-DRE-1660499", "R-RNO-2559585", "R-PFA-5689880", "R-DME-8939243", "R-HSA-6809371", "R-CEL-983695", "R-HSA-3108214", "R-HSA-9725554", "R-MMU-9013148", "R-HSA-8953750", "R-HSA-1660499", "R-RNO-1912408", "R-HSA-6794361", "R-DME-2559580", "R-HSA-114508", "R-DME-3899300", "R-CEL-181429", "R-HSA-9938206", "R-HSA-6803211", "R-DME-209190", "R-CEL-6794361", "R-DDI-3295583", "R-SCE-2559580", "R-RNO-5578775", "R-HSA-9927432", "R-DME-4551638", "R-DME-983695", "R-HSA-983168", "R-HSA-166166", "R-PFA-5675482", "R-HSA-3928663", "R-CFA-912526", "R-CEL-5578775", "R-MMU-3928662", "R-RNO-1855204", "R-DRE-3928665", "R-HSA-9013406", "R-HSA-3899300", "R-PFA-5357905", "R-MMU-114604", "R-HSA-5689880", "R-MMU-9013408", "R-MMU-937072", "R-HSA-6804759", "R-MMU-4551638", "R-HSA-5673000", "R-DDI-5213460", "R-MMU-9013420", "R-HSA-8853659", "R-DDI-5673000", "R-CEL-388844", "R-HSA-2682334", "R-HSA-9616222", "R-MMU-5620912", "R-HSA-210500", "R-HSA-114604", "R-MMU-6804760", "R-HSA-181430", "R-HSA-2424491", "R-PFA-5689896", "R-PFA-5673000", "R-MMU-9031628", "R-HSA-9696264", "R-MMU-9013423", "R-MMU-1483166", "R-MMU-1912408", "R-HSA-9013026", "R-HSA-9031628", "R-HSA-212676", "R-MMU-5675221", "R-HSA-9656223", "R-MMU-8980692", "R-HSA-9013106", "R-DME-114508", "R-HSA-1483166", "R-HSA-373760", "R-DME-1660661", "R-MMU-388844", "R-MMU-8939236", "R-HSA-9013423", "R-DRE-3108214", "R-HSA-181429", "R-DME-8953750", "R-MMU-6804759", "R-DME-3108214", "R-MMU-3928664", "R-MMU-212676", "R-RNO-181430", "R-RNO-2682334", "R-DDI-392517", "R-SCE-1660499", "R-PFA-5675221", "R-CEL-2559580", "R-MMU-1660499", "R-MMU-8943724", "R-DRE-3899300", "R-RNO-1660499", "R-HSA-912526", "R-HSA-8956319", "R-RNO-1660661", "R-MMU-9013149", "R-HSA-8939236", "R-MMU-2559585", "R-HSA-9927426", "R-MMU-8956319", "R-MMU-8953750", "R-MMU-204005", "R-HSA-139853", "R-HSA-5674135", "R-DRE-1855204", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-9927418", "R-HSA-3928662", "R-MMU-2871796", "R-HSA-5545619", "R-HSA-9649948", "R-HSA-4641257", "R-RNO-9013406", "R-CEL-264642", "R-HSA-4551638", "R-HSA-5601884", "R-CFA-1855204", "R-RNO-8853659", "R-MMU-8853659", "R-MMU-5578775", "R-DDI-380972", "R-PFA-5213460", "R-RNO-9696273", "R-HSA-9013404", "R-MMU-264642", "R-HSA-9013149", "R-HSA-8980692", "R-RNO-264642", "R-HSA-8948751", "R-RNO-181429", "R-RNO-9696270", "R-SPO-2559580", "R-HSA-2559585", "R-HSA-9619665", "R-HSA-5628897", "R-HSA-1912408", "R-DME-209214", "R-RNO-166166", "R-HSA-6802946", "R-HSA-5578775", "R-RNO-9013106", "R-CEL-1660661", "R-HSA-5620912", "R-MMU-1855204", "R-HSA-937072", "R-RNO-170984", "R-DRE-2682334", "R-RNO-6809371", "R-HSA-9013420", "R-MMU-202433", "R-MMU-8849469", "R-DRE-8956319", "R-HSA-9662361", "R-MMU-6794361", "R-MMU-2682334", "R-MMU-3928663", "R-MMU-181429", "R-MMU-983695", "R-HSA-1660661", "R-MMU-8939243", "R-DDI-5621575", "R-HSA-9703465", "R-GGA-2559585", "R-MMU-2871809", "R-HSA-6803204", "R-MMU-9013026", "R-DDI-168638", "R-MMU-2424491", "R-MMU-983168", "R-HSA-2892247", "R-MMU-9696270", "R-DRE-3928663", "R-HSA-5675221"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DME-2559585:r:Oncogene Induced Senescence", "R-DRE-3928664:r:Ephrin signaling", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-170984:r:ARMS-mediated activation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-MMU-5673000:r:RAF activation", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-BTA-8956319:r:Nucleotide catabolism", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-HSA-202433:r:Generation of second messenger molecules", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-5620971:r:Pyroptosis", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-9824272:r:Somitogenesis", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-936964:r:Activation of IRF3, IRF7 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"R-MMU-73772", "R-HSA-2644606", "R-MMU-5687128", "R-MMU-69273", "R-DDI-69202", "R-SCE-73776", "R-RNO-2173796", "R-DME-69017", "R-BTA-69478", "R-HSA-68949", "R-RNO-8963901", "R-RNO-9754119", "R-HSA-6781827", "R-CEL-8951936", "R-DME-2995383", "R-MMU-2980767", "R-MMU-8852276", "R-BTA-176412", "R-RNO-8849470", "R-MMU-68949", "R-BTA-176417", "R-HSA-9682706", "R-MMU-8934593", "R-DME-73779", "R-MMU-8939236", "R-MMU-6781823", "R-CEL-69656", "R-HSA-8849470", "R-CEL-2559586", "R-SPO-69656", "R-CEL-75815", "R-HSA-1538133", "R-HSA-2559584", "R-MMU-6804116", "R-MMU-73776", "R-GGA-69273", "R-RNO-9707616", "R-SPO-9754119", "R-DRE-75815", "R-HSA-167172", "R-BTA-1538133", "R-MMU-5693607", "R-BTA-212436", "R-HSA-176412", "R-MMU-176408", "R-RNO-113418", "R-CEL-75955", "R-MMU-8951936", "R-MMU-176417", "R-SPO-69231", "R-HSA-156711", "R-MMU-6804757", "R-DME-176412", "R-MMU-113501", "R-RNO-75815", "R-HSA-2995383", "R-CEL-176408", "R-XTR-8951664", "R-RNO-69273", "R-CEL-8878166", "R-RNO-69231", "R-SPO-75815", "R-CEL-5689880", "R-SCE-9018519", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-MMU-2299718", "R-DME-174178", "R-BTA-69200", "R-DME-2173796", "R-CEL-69478", "R-SPO-68949", "R-DME-75035", "R-BTA-8878166", "R-BTA-6807505", "R-RNO-3000480", "R-MMU-6804114", "R-HSA-8939236", "R-HSA-112382", "R-HSA-73779", "R-HSA-6804116", "R-HSA-1989781", "R-BTA-69231", "R-RNO-2995383", "R-SCE-75953", "R-MMU-113418", "R-RNO-3214858", "R-CEL-3301854", "R-DME-69231", "R-DRE-8951664", "R-SPO-6807505", "R-CEL-187577", "R-RNO-8964026", "R-MMU-76066", "R-RNO-73863", "R-RNO-3000471", "R-DRE-6807505", "R-DRE-6796648", "R-BTA-2995383", "R-RNO-202733", "R-MMU-9929491", "R-HSA-2980767", "R-HSA-8878166", "R-GGA-69231", "R-MMU-73779", "R-HSA-9825892", "R-CEL-69563", "R-HSA-9018519", "R-RNO-1538133", "R-HSA-176408", "R-SPO-75953", "R-MMU-68911", "R-DME-5693607", "R-MMU-76042", "R-CEL-2500257", "R-CEL-6807505", "R-RNO-76042", "R-DRE-1538133", "R-DDI-72086", "R-HSA-6785807", "R-MMU-674695", "R-MMU-8878166", "R-DME-8878166", "R-MMU-69478", "R-GGA-8934593", "R-DDI-6807505", "R-MMU-9018519", "R-HSA-3301854", "R-CEL-9929491", "R-RNO-113501", "R-HSA-2465910", "R-HSA-1362277", "R-DRE-8934593", "R-SCE-674695", "R-GGA-2995383", "R-MMU-6782210", "R-RNO-4419969", "R-RNO-983168", "R-CEL-6796648", "R-HSA-2559586", "R-MMU-69231", "R-HSA-8853884", "R-MMU-73762", "R-HSA-187577", "R-SPO-176408", "R-HSA-8951430", "R-SPO-5687128", "R-HSA-69205", "R-MMU-6782135", "R-DRE-9754119", "R-HSA-76066", "R-RNO-8934593", "R-HSA-2559585", "R-DRE-6804116", "R-DME-6796648", "R-RNO-2559584", "R-HSA-72086", "R-HSA-2559582", "R-HSA-68875", "R-HSA-174184", "R-HSA-3214858", "R-MMU-174048", "R-HSA-1912408", "R-HSA-167162", "R-DRE-9929491", "R-CEL-1538133", "R-RNO-8957275", "R-HSA-167152", "R-SPO-983168", "R-RNO-6804756", "R-SPO-3214858", "R-HSA-9833110", "R-RNO-975634", "R-SCE-6782210", "R-RNO-69200", "R-BTA-6796648", "R-HSA-2173796", "R-DME-68949", "R-DME-4419969", "R-SCE-6796648", "R-DRE-8849470", "R-RNO-2299718", "R-RNO-2559586", "R-SPO-77075", "R-BTA-69273", "R-RNO-73772", "R-HSA-390471", "R-HSA-1362300", "R-SCE-113418", "R-BTA-174048", "R-HSA-8852276", "R-RNO-9706019", "R-MMU-73863", "R-DRE-69200", "R-HSA-6782135", "R-RNO-6782135", "R-MMU-69563", "R-CEL-68949", "R-DRE-674695", "R-HSA-5687128", "R-DME-9841922", "R-HSA-176034", "R-MMU-983168", "R-MMU-4419969", "R-DDI-75953", "R-DRE-3214858", "R-CEL-76042", "R-HSA-176417", "R-GGA-2980767"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8951664:r:Neddylation", "R-MMU-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-1538133:r:G0 and Early G1", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-8964038:r:LDL clearance", "R-BTA-68875:r:Mitotic Prophase", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-8964046:r:VLDL clearance", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-69478:r:G2/M DNA replication checkpoint", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-BTA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-RNO-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-GGA-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-DME-1538133:r:G0 and Early G1", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-8951664:r:Neddylation", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-68911:r:G2 Phase", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-8866423:r:VLDL assembly", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68875:r:Mitotic Prophase", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-69478:r:G2/M DNA replication checkpoint", "R-BTA-69563:r:p53-Dependent G1 DNA Damage Response", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-68875:r:Mitotic Prophase", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-DME-68875:r:Mitotic Prophase", "R-DME-69478:r:G2/M DNA replication checkpoint", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-BTA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-MMU-8951664:r:Neddylation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-68911:r:G2 Phase", "R-DRE-69231:r:Cyclin D associated events in G1", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-SPO-72086:r:mRNA Capping", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-DRE-69202:r:Cyclin E associated events during G1/S transition", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DRE-9706019:r:RHOBTB3 ATPase cycle", "R-BTA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", 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"pathway_ids": ["R-HSA-9013405", "R-MMU-9035034", "R-HSA-9925563", "R-MMU-1237044", "R-HSA-425381", "R-BTA-425381", "R-MMU-9013407", "R-HSA-1247673", "R-RNO-1237044", "R-RNO-1247673", "R-MMU-425381", "R-DRE-425381", "R-RNO-9035034", "R-MMU-1247673", "R-RNO-9013407", "R-HSA-5619054", "R-HSA-1237044", "R-HSA-5619050", "R-MMU-9013406", "R-HSA-9035034", "R-RNO-9013406", "R-HSA-9013406", "R-HSA-9013409", "R-RNO-425381", "R-HSA-9013407"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-425381:r:Bicarbonate transporters", "R-BTA-425381:r:Bicarbonate transporters", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon 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"R-HSA-5628897", "R-CEL-9013149", "R-CEL-1474228", "R-RNO-418889", "R-CEL-399955", "R-DME-5620916", "R-DME-9913351", "R-MMU-2428928", "R-GGA-6811558", "R-HSA-912694", "R-RNO-6804756", "R-DME-209394", "R-RNO-373752", "R-MMU-1855183", "R-HSA-420597", "R-RNO-170984", "R-MMU-1855204", "R-HSA-5658623", "R-RNO-8932505", "R-HSA-9734091", "R-RNO-6809371", "R-CEL-9913351", "R-HSA-9013420", "R-DME-376172", "R-DRE-9843970", "R-HSA-9032500", "R-HSA-1660661", "R-MMU-2454202", "R-DME-8849932", "R-HSA-8985586", "R-MMU-2871809", "R-SPO-9609523", "R-BTA-909733", "R-MMU-9013026", "R-SSC-8875791", "R-HSA-9022699", "R-RNO-1250196", "R-DME-5654726", "R-MMU-1442490", "R-DME-420597", "R-HSA-879415", "R-RNO-1250347", "R-HSA-9669921", "R-HSA-6802952", "R-RNO-9013409", "R-RNO-372708", "R-MMU-6811558", "R-HSA-140837", "R-MMU-433692", "R-RNO-9020558", "R-HSA-420029", "R-DRE-202733", "R-RNO-187042", "R-HSA-9732724", "R-HSA-1306955", "R-GGA-354192", "R-MMU-418889", "R-RNO-416550", "R-DRE-388844", "R-RNO-193692", "R-MMU-202430", "R-DRE-3928664", "R-RNO-399954", "R-HSA-3134963", "R-HSA-5632681", "R-HSA-9844594", "R-HSA-8948216", "R-DME-214869", "R-MMU-1810476", "R-DME-5676590", "R-DRE-198933", "R-DRE-416550", "R-HSA-5223345", "R-MMU-186763", "R-HSA-5607761", "R-SSC-2022854", "R-HSA-74713", "R-HSA-1170546", "R-HSA-983695", "R-DME-210991", "R-DME-6785631", "R-HSA-5083633", "R-GGA-5654726", "R-HSA-9927353", "R-MMU-5140745", "R-HSA-419037", "R-MMU-173736", "R-HSA-9820960", "R-HSA-9008059", "R-HSA-8866654", "R-BTA-1632852", "R-DME-416572", "R-HSA-909733", "R-HSA-3656225", "R-MMU-216083", "R-RNO-388844", "R-BTA-8980692", "R-HSA-389357", "R-DME-416700", "R-HSA-140834", "R-CEL-6811558", "R-MMU-170984", "R-MMU-6785807", "R-MMU-354192", "R-HSA-8865999", "R-BTA-375276", "R-HSA-9702620", "R-MMU-5654227", "R-HSA-9833109", "R-BTA-8985947", "R-RNO-2172127", "R-DME-350054", "R-DME-1971475", "R-CEL-5654720", "R-HSA-8849932", "R-DRE-5654221", "R-MMU-173623", "R-DRE-983168", "R-RNO-416482", "R-RNO-389359", "R-HSA-877312", "R-MMU-2132295", "R-RNO-3928662", "R-RNO-2022870", "R-HSA-190372", "R-SCE-163680", "R-MMU-5660668", "R-HSA-5655332", "R-SPO-5628897", "R-DME-5654719", "R-HSA-2871809", "R-XTR-5654687", "R-BTA-8849932", "R-HSA-110056", "R-HSA-1358803", "R-HSA-9669934", "R-DDI-5675221", "R-GGA-9843940", "R-HSA-8853336", "R-MMU-2029481", "R-MMU-389513", "R-RNO-74713", "R-HSA-9725371", "R-HSA-5173214", "R-RNO-9032759", "R-RNO-173736", "R-CEL-8941413", "R-HSA-9856649", "R-DRE-4420097", "R-HSA-8853333", "R-HSA-9702518", "R-HSA-391160", "R-HSA-3595174", "R-MMU-1433559", "R-SSC-9020591", "R-HSA-9920588", "R-HSA-8856828", "R-SSC-9013408", "R-BTA-202424", "R-HSA-5654228", "R-MMU-373756", "R-HSA-2029481", "R-RNO-8983432", "R-RNO-9027276", "R-CEL-5673001", "R-HSA-5694530", "R-BTA-5576892", "R-BTA-418594", "R-CEL-5654732", "R-MMU-381426", "R-MMU-399954", "R-RNO-170968", "R-BTA-2022870", "R-CFA-2024101", "R-HSA-9673767", "R-CEL-5654228", "R-HSA-9007892", "R-RNO-3000178", "R-RNO-8865999", "R-DME-5654227", "R-CEL-525793", "R-HSA-9927354", "R-HSA-447043", "R-HSA-5603029", "R-HSA-2404192", "R-MMU-1433557", "R-MMU-5620916", "R-HSA-209560", "R-MMU-5621575", "R-MMU-5635838", "R-RNO-9014826", "R-HSA-166058", "R-HSA-451927", "R-MMU-1236977", "R-HSA-9694614", "R-HSA-9020933", "R-HSA-9673768", "R-MMU-373753", "R-MMU-9013406", "R-MMU-6798695", "R-CEL-186763", "R-BTA-1236974", "R-HSA-5083628", "R-MMU-9034013", "R-RNO-376172", "R-MMU-416700", "R-GGA-1306955", "R-MMU-114608", "R-HSA-416550", "R-HSA-9619483", "R-HSA-6809371", "R-CEL-8863795", "R-MMU-112411", "R-RNO-1059683", "R-RNO-2029482", "R-HSA-2871837", "R-HSA-210990", "R-CEL-5654706", "R-DRE-2132295", "R-HSA-8932506", "R-HSA-174577", "R-DME-9009391", "R-SSC-2029482", "R-MMU-9609523", "R-DRE-449836", "R-RNO-1307965", "R-DME-1250347", "R-HSA-432722", "R-HSA-380972", "R-RNO-1810476", "R-HSA-1839122", "R-HSA-8875791", "R-HSA-8963896", "R-BTA-202430", "R-HSA-445355", "R-HSA-1462054", "R-HSA-2173791", "R-HSA-5654706", "R-RNO-186797", "R-GGA-434001", "R-DRE-9856649", "R-HSA-2160916", "R-HSA-1660514", "R-HSA-9824585", "R-DRE-1300645", "R-HSA-5654227", "R-DRE-9013148", "R-MMU-1059683", "R-RNO-74751", "R-HSA-3928663", "R-RNO-9007892", "R-CEL-4420097", "R-MMU-6806942", "R-HSA-5627123", "R-DRE-190375", "R-MMU-416482", "R-MMU-9927354", "R-RNO-1855204", "R-GGA-190373", "R-DRE-5654695", "R-DRE-3928665", "R-HSA-8957275", "R-HSA-9664422", "R-HSA-9702600", "R-SSC-8875656", "R-CEL-5218920", "R-SSC-2730905", "R-HSA-2243919", "R-MMU-210991", "R-HSA-3560783", "R-RNO-1474228", "R-MMU-9013408", "R-RNO-140875", "R-MMU-210990", "R-MMU-210993", "R-HSA-9856532", "R-DME-5654732", "R-BTA-912694", "R-BTA-8957275", "R-HSA-9674401", "R-MMU-5632681", "R-HSA-166665", "R-MMU-9013420", "R-HSA-9702632", "R-CEL-190373", "R-HSA-166663", "R-DME-209209", "R-HSA-446107", "R-MMU-5673001", "R-HSA-9701898", "R-HSA-2586552", "R-MMU-449836", "R-RNO-1855183", "R-HSA-9026527", "R-HSA-181430", "R-HSA-182971", "R-RNO-1566977", "R-HSA-2424491", "R-MMU-9939291", "R-RNO-5628897", "R-HSA-9674396", "R-CFA-983695", "R-MMU-190372", "R-HSA-8983432", "R-HSA-164939", "R-SSC-9027284", "R-RNO-174577", "R-HSA-164940", "R-GGA-5674135", "R-HSA-2022090", "R-RNO-879415", "R-HSA-8853383", "R-HSA-445144", "R-MMU-5627123", "R-HSA-2644606", "R-HSA-917977", "R-GGA-9749641", "R-BTA-202433", "R-BTA-1236977", "R-MMU-9860927", "R-MMU-416550", "R-RNO-8851907", "R-HSA-8857538", "R-SSC-8875513", "R-DME-983168", "R-XTR-202433", "R-HSA-416572", "R-HSA-5607763", "R-HSA-9772755", "R-RNO-9851151", "R-MMU-380972", "R-MMU-8980692", "R-MMU-2122947", "R-MMU-430116", "R-GGA-163125", "R-HSA-2029485", "R-HSA-373760", "R-MMU-388844", "R-MMU-9664873", "R-HSA-9013423", "R-HSA-190374", "R-MMU-190370", "R-CEL-190377", "R-HSA-8851907", "R-BTA-912526", "R-CFA-6811558", "R-DME-2024101", "R-CEL-373752", "R-MMU-512988", "R-HSA-1250196", "R-MMU-9772755", "R-HSA-9669926", "R-DRE-8957275", "R-MMU-3928664", "R-SSC-2029481", "R-BTA-8856828", "R-MMU-437239", "R-RNO-446107", "R-MMU-977606", "R-MMU-212676", "R-MMU-391160", "R-MMU-9028731", "R-HSA-376176", "R-RNO-1227986", "R-MMU-1169091", "R-HSA-380270", "R-HSA-1236977", "R-MMU-1660499", "R-SSC-202424", "R-DME-1474228", "R-MMU-8851680"], "pathways": ["R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9953038:r:MPS I - Hurler syndrome (CS/DS degradation)", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-8875656:r:MET receptor recycling", "R-CEL-186797:r:Signaling by PDGF", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-SSC-2160916:r:Hyaluronan degradation", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-CFA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-187042:r:TRKA activation by NGF", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9020933:r:Interleukin-23 signaling", "R-RNO-9014843:r:Interleukin-33 signaling", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-9927353:r:Co-inhibition by BTLA", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CFA-9927354:r:Co-stimulation by ICOS", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-3322077:r:Glycogen synthesis", "R-SSC-202433:r:Generation of second messenger molecules", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-1227986:r:Signaling by ERBB2", "R-DRE-9007892:r:Interleukin-38 signaling", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-GGA-2132286:r:Classical antibody-mediated complement activation", "R-CFA-389948:r:Co-inhibition by PD-1", "R-DRE-190373:r:FGFR1c ligand binding and activation", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-6809371:r:Formation of the cornified envelope", "R-RNO-433692:r:Proton-coupled monocarboxylate transport", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-HSA-3000157:r:Laminin interactions", "R-SSC-114608:r:Platelet degranulation", "R-CEL-416700:r:Other semaphorin interactions", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-416476:r:G alpha (q) signalling events", "R-CFA-5690714:r:CD22 mediated BCR regulation", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-418885:r:DCC mediated attractive signaling", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-HSA-448706:r:Interleukin-1 processing", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-5619070:r:Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-354192:r:Integrin signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-SSC-6807004:r:Negative regulation of MET activity", "R-RNO-210991:r:Basigin interactions", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-77387:r:Insulin receptor recycling", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-418990:r:Adherens junctions interactions", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-RNO-389356:r:Co-stimulation by CD28", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9830674:r:Formation of the ureteric bud", "R-MMU-8963896:r:HDL assembly", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-CFA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-2160916:r:Hyaluronan degradation", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8951664:r:Neddylation", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-74752:r:Signaling by Insulin receptor", "R-MMU-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-9014843:r:Interleukin-33 signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-4755510:r:SUMOylation of immune response proteins", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DME-3000178:r:ECM proteoglycans", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-SSC-2132295:r:MHC class II antigen presentation", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-SCE-200425:r:Carnitine shuttle", "R-MMU-8932506:r:DAG1 core M1 glycosylations", "R-BTA-977606:r:Regulation of Complement cascade", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-9702509:r:FLT3 mutants bind TKIs", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-186763:r:Downstream signal transduction", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-389356:r:Co-stimulation by CD28", "R-MMU-448706:r:Interleukin-1 processing", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9702581:r:crenolanib-resistant FLT3 mutants", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-SSC-6798695:r:Neutrophil degranulation", "R-DRE-109704:r:PI3K Cascade", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9824272:r:Somitogenesis", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-GGA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-GGA-449836:r:Other interleukin signaling", "R-MMU-74713:r:IRS activation", "R-HSA-8852405:r:Signaling by MST1", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-XTR-418990:r:Adherens junctions interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-2022857:r:Keratan sulfate degradation", "R-RNO-166665:r:Terminal pathway of complement", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-CEL-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-BTA-210993:r:Tie2 Signaling", "R-DRE-193648:r:NRAGE signals death through JNK", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-RNO-9020702:r:Interleukin-1 signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-CFA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-8875791:r:MET activates STAT3", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-MMU-8865999:r:MET activates PTPN11", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-MMU-432142:r:Platelet sensitization by LDL", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-187042:r:TRKA activation by NGF", "R-DRE-418990:r:Adherens junctions interactions", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-GGA-373920:r:Pyruvate metabolism", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-373753:r:Nephrin family interactions", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1462054:r:Alpha-defensins", "R-RNO-8963896:r:HDL assembly", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SSC-216083:r:Integrin cell surface interactions", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-CEL-419037:r:NCAM1 interactions", "R-CEL-209968:r:Thyroxine biosynthesis", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9702605:r:pexidartinib-resistant FLT3 mutants", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8964046:r:VLDL clearance", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9702614:r:ponatinib-resistant FLT3 mutants", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-2024096:r:HS-GAG degradation", "R-GGA-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-2024096:r:HS-GAG degradation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-SSC-2871796:r:FCERI mediated MAPK activation", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-9020591:r:Interleukin-12 signaling", "R-RNO-390522:r:Striated Muscle Contraction", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-SSC-2424491:r:DAP12 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-977606:r:Regulation of Complement cascade", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9953080:r:MPS VII - Sly syndrome (CS/DS degradation)", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-1236394:r:Signaling by ERBB4", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-SSC-5690714:r:CD22 mediated BCR regulation", "R-MMU-1266695:r:Interleukin-7 signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-167021:r:PLC-gamma1 signalling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-MMU-3000170:r:Syndecan interactions", "R-GGA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-9634597:r:GPER1 signaling", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-SSC-982772:r:Growth hormone receptor signaling", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-447038:r:NrCAM interactions", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-77387:r:Insulin receptor recycling", "R-MMU-9007892:r:Interleukin-38 signaling", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-447043:r:Neurofascin interactions", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-HSA-9609690:r:HCMV Early Events", "R-BTA-8983432:r:Interleukin-15 signaling", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-420029:r:Tight junction interactions", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-8851805:r:MET activates RAS signaling", "R-HSA-433692:r:Proton-coupled monocarboxylate transport", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-173736:r:Alternative complement activation", "R-RNO-8951664:r:Neddylation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SSC-389948:r:Co-inhibition by PD-1", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-6806942:r:MET Receptor Activation", "R-GGA-8932505:r:DAG1 core M3 glycosylations", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-8874081:r:MET activates PTK2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-HSA-1442490:r:Collagen degradation", "R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-RNO-416700:r:Other semaphorin interactions", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-GGA-210991:r:Basigin interactions", "R-SCE-9013106:r:RHOC GTPase cycle", "R-MMU-447043:r:Neurofascin interactions", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-CEL-77387:r:Insulin receptor recycling", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-CFA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-3214847:r:HATs acetylate histones", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-200425:r:Carnitine shuttle", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-MMU-182971:r:EGFR downregulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-CFA-202433:r:Generation of second messenger molecules", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-166663:r:Initial triggering of complement", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-74749:r:Signal attenuation", "R-GGA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-448706:r:Interleukin-1 processing", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DME-9749641:r:Aspirin ADME", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SPO-200425:r:Carnitine shuttle", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-9613354:r:Lipophagy", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-DRE-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-209400:r:Transcriptional activtion by phosphorylated DL/DIF dimer", "R-MMU-420029:r:Tight junction interactions", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-MMU-390522:r:Striated Muscle Contraction", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5689603:r:UCH proteinases", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-MMU-419037:r:NCAM1 interactions", "R-HSA-9669933:r:Signaling by kinase domain mutants of KIT", "R-RNO-264876:r:Insulin processing", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-977443:r:GABA receptor activation", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-BTA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-9014826:r:Interleukin-36 pathway", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-CFA-202424:r:Downstream TCR signaling", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-4086400:r:PCP/CE pathway", "R-BTA-9020958:r:Interleukin-21 signaling", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-CFA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-877300:r:Interferon gamma signaling", "R-GGA-1433559:r:Regulation of KIT signaling", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-9749641:r:Aspirin ADME", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-GGA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9702624:r:sorafenib-resistant FLT3 mutants", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-BTA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-418990:r:Adherens junctions interactions", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-SSC-210990:r:PECAM1 interactions", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-1236394:r:Signaling by ERBB4", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-210991:r:Basigin interactions", "R-CFA-8932505:r:DAG1 core M3 glycosylations", "R-HSA-170984:r:ARMS-mediated activation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CEL-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-DME-109704:r:PI3K Cascade", "R-MMU-200425:r:Carnitine shuttle", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-GGA-2129379:r:Molecules associated with elastic fibres", "R-HSA-437239:r:Recycling pathway of L1", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-DRE-216083:r:Integrin cell surface interactions", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-GGA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DME-977068:r:Termination of O-glycan biosynthesis", "R-CFA-2024096:r:HS-GAG degradation", "R-RNO-216083:r:Integrin cell surface interactions", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-SSC-8980692:r:RHOA GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-MMU-166665:r:Terminal pathway of complement", "R-CEL-2024096:r:HS-GAG degradation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-HSA-1483115:r:Hydrolysis of LPC", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-3000170:r:Syndecan interactions", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-209968:r:Thyroxine biosynthesis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-DME-9020702:r:Interleukin-1 signaling", "R-SSC-9013106:r:RHOC GTPase cycle", "R-BTA-216083:r:Integrin cell surface interactions", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-MMU-2024096:r:HS-GAG degradation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9012546:r:Interleukin-18 signaling", "R-MMU-5694530:r:Cargo concentration in the ER", "R-MMU-74752:r:Signaling by Insulin receptor", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-SSC-173623:r:Classical antibody-mediated complement activation", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-HSA-373753:r:Nephrin family interactions", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-GGA-216083:r:Integrin cell surface interactions", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SSC-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-5635838:r:Activation of SMO", "R-MMU-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-3878781:r:Glycogen storage disease type IV (GBE1)", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-GGA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-167044:r:Signalling to RAS", "R-DME-419037:r:NCAM1 interactions", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-3000178:r:ECM proteoglycans", "R-RNO-109704:r:PI3K Cascade", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-264876:r:Insulin processing", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-RNO-5689603:r:UCH proteinases", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CFA-8932504:r:DAG1 core M2 glycosylations", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-525793:r:Myogenesis", "R-BTA-2024101:r:CS/DS degradation", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-9645135:r:STAT5 Activation", "R-HSA-373756:r:SDK interactions", "R-CFA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-BTA-8932505:r:DAG1 core M3 glycosylations", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-449836:r:Other interleukin signaling", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9702596:r:lestaurtinib-resistant FLT3 mutants", "R-CEL-3000178:r:ECM proteoglycans", "R-RNO-373753:r:Nephrin family interactions", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-5673000:r:RAF activation", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-6806942:r:MET Receptor Activation", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-1236977:r:Endosomal/Vacuolar pathway", "R-SSC-2022857:r:Keratan sulfate degradation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-447041:r:CHL1 interactions", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9703009:r:tamatinib-resistant FLT3 mutants", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-SSC-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-8985947:r:Interleukin-9 signaling", "R-DME-373752:r:Netrin-1 signaling", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-GGA-9634597:r:GPER1 signaling", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-SSC-1236974:r:ER-Phagosome pathway", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2206292:r:MPS VII - Sly syndrome (Hyaluronan metabolism)", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-SSC-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9674404:r:Sorafenib-resistant PDGFR mutants", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-4086398:r:Ca2+ pathway", "R-GGA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-GGA-1250196:r:SHC1 events in ERBB2 signaling", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-MMU-109704:r:PI3K Cascade", "R-RNO-9664873:r:Pexophagy", "R-DRE-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-SSC-8875555:r:MET activates RAP1 and RAC1", "R-RNO-447043:r:Neurofascin interactions", "R-CFA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-SCE-3322077:r:Glycogen synthesis", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-BTA-174577:r:Activation of C3 and C5", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-DME-3214847:r:HATs acetylate histones", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-GGA-3214841:r:PKMTs methylate histone lysines", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-GGA-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-9702569:r:KW2449-resistant FLT3 mutants", "R-SSC-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-74749:r:Signal attenuation", "R-GGA-1236394:r:Signaling by ERBB4", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-GGA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-CEL-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-373753:r:Nephrin family interactions", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8964038:r:LDL clearance", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-MMU-2214320:r:Anchoring fibril formation", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-190370:r:FGFR1b ligand binding and activation", "R-RNO-202424:r:Downstream TCR signaling", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-177929:r:Signaling by EGFR", "R-GGA-193634:r:Axonal growth inhibition (RHOA activation)", "R-GGA-3000170:r:Syndecan interactions", "R-SSC-3000178:r:ECM proteoglycans", "R-HSA-2024101:r:CS/DS degradation", "R-DRE-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-GGA-1236974:r:ER-Phagosome pathway", "R-RNO-420029:r:Tight junction interactions", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DRE-5654710:r:PI-3K cascade:FGFR3", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-9014826:r:Interleukin-36 pathway", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-376172:r:DSCAM interactions", "R-MMU-1462054:r:Alpha-defensins", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-BTA-9013106:r:RHOC GTPase cycle", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-RNO-166663:r:Initial triggering of complement", "R-RNO-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-3322077:r:Glycogen synthesis", "R-SSC-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-MMU-8948216:r:Collagen chain trimerization", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CFA-1433559:r:Regulation of KIT signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-SSC-2024101:r:CS/DS degradation", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-5689603:r:UCH proteinases", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-202433:r:Generation of second messenger molecules", "R-CEL-264876:r:Insulin processing", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1566977:r:Fibronectin matrix formation", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-418990:r:Adherens junctions interactions", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-2022928:r:HS-GAG biosynthesis", "R-GGA-1566977:r:Fibronectin matrix formation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-1236974:r:ER-Phagosome pathway", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-SSC-8851805:r:MET activates RAS signaling", "R-DRE-416476:r:G alpha (q) signalling events", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9696273:r:RND1 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-9013026:r:RHOB GTPase cycle", "R-RNO-190322:r:FGFR4 ligand binding and activation", "R-SSC-2168880:r:Scavenging of heme from plasma", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-198745:r:Signalling to STAT3", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-CFA-8932506:r:DAG1 core M1 glycosylations", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9702577:r:semaxanib-resistant FLT3 mutants", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-HSA-2206302:r:MPS I - Hurler syndrome (HS-GAG degradation)", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-SCE-1632852:r:Macroautophagy", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-5083629:r:Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-9634597:r:GPER1 signaling", "R-GGA-3000178:r:ECM proteoglycans", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-RNO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-HSA-114608:r:Platelet degranulation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9020591:r:Interleukin-12 signaling", "R-RNO-354192:r:Integrin signaling", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-8983711:r:OAS antiviral response", "R-MMU-1566977:r:Fibronectin matrix formation", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-HSA-74749:r:Signal attenuation", "R-CEL-9749641:r:Aspirin ADME", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9014843:r:Interleukin-33 signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-SPO-9664873:r:Pexophagy", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-MTU-868688:r:Trehalose biosynthesis", "R-CEL-216083:r:Integrin cell surface interactions", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-HSA-2172127:r:DAP12 interactions", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-BTA-445355:r:Smooth Muscle Contraction", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-MMU-6809371:r:Formation of the cornified envelope", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-264876:r:Insulin processing", "R-HSA-9012546:r:Interleukin-18 signaling", "R-HSA-1632852:r:Macroautophagy", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DRE-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-913709:r:O-linked glycosylation of mucins", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-SPO-1632852:r:Macroautophagy", "R-HSA-844456:r:The NLRP3 inflammasome", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-BTA-173736:r:Alternative complement activation", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-373760:r:L1CAM interactions", "R-RNO-1236974:r:ER-Phagosome pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-CFA-216083:r:Integrin cell surface interactions", "R-RNO-114608:r:Platelet degranulation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8852405:r:Signaling by MST1", "R-HSA-977606:r:Regulation of Complement cascade", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-2024101:r:CS/DS degradation", "R-MMU-174577:r:Activation of C3 and C5", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DME-5689603:r:UCH proteinases", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-RNO-446353:r:Cell-extracellular matrix interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-CEL-445144:r:Signal transduction by L1", "R-DDI-3295583:r:TRP channels", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-5683826:r:Surfactant metabolism", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-DME-447043:r:Neurofascin interactions", "R-MMU-6783783:r:Interleukin-10 signaling", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-BTA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-3928664:r:Ephrin signaling", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-GGA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-HSA-264876:r:Insulin processing", "R-RNO-202433:r:Generation of second messenger molecules", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-RNO-525793:r:Myogenesis", "R-HSA-6806942:r:MET Receptor Activation", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-1632852:r:Macroautophagy", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-RNO-210990:r:PECAM1 interactions", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-9020558:r:Interleukin-2 signaling", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-173107:r:Binding and entry of HIV virion", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-SSC-1236977:r:Endosomal/Vacuolar pathway", "R-RNO-2029481:r:FCGR activation", "R-DME-114608:r:Platelet degranulation", "R-SSC-432142:r:Platelet sensitization by LDL", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-2022857:r:Keratan sulfate degradation", "R-HSA-9702590:r:gilteritinib-resistant FLT3 mutants", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-CFA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9031628:r:NGF-stimulated transcription", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-BTA-77387:r:Insulin receptor recycling", "R-MMU-186797:r:Signaling by PDGF", "R-HSA-1483152:r:Hydrolysis of LPE", "R-BTA-2424491:r:DAP12 signaling", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9664873:r:Pexophagy", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-2172127:r:DAP12 interactions", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-SSC-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-9702636:r:tandutinib-resistant FLT3 mutants", "R-RNO-1170546:r:Prolactin receptor signaling", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-GGA-114608:r:Platelet degranulation", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-74752:r:Signaling by Insulin receptor", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-SSC-8865999:r:MET activates PTPN11", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-MMU-373752:r:Netrin-1 signaling", "R-RNO-3000170:r:Syndecan interactions", "R-RNO-419037:r:NCAM1 interactions", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-373760:r:L1CAM interactions", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-DME-209560:r:NF-kB is activated and signals survival", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-6783783:r:Interleukin-10 signaling", "R-CEL-190322:r:FGFR4 ligand binding and activation", "R-GGA-8854691:r:Interleukin-20 family signaling", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-DME-1236394:r:Signaling by ERBB4", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-77387:r:Insulin receptor recycling", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-5690714:r:CD22 mediated BCR regulation", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-110478:r:Insulin signaling pathway", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-9620244:r:Long-term potentiation", "R-HSA-9702998:r:linifanib-resistant FLT3 mutants", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-376172:r:DSCAM interactions", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-190370:r:FGFR1b ligand binding and activation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-RNO-418990:r:Adherens junctions interactions", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-RNO-373752:r:Netrin-1 signaling", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-420597:r:Nectin/Necl trans heterodimerization", "R-RNO-170984:r:ARMS-mediated activation", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-RNO-8932505:r:DAG1 core M3 glycosylations", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-RNO-6809371:r:Formation of the cornified envelope", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DME-376172:r:DSCAM interactions", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SSC-8875791:r:MET activates STAT3", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-1442490:r:Collagen degradation", "R-DME-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-433692:r:Proton-coupled monocarboxylate transport", "R-RNO-9020558:r:Interleukin-2 signaling", "R-HSA-420029:r:Tight junction interactions", "R-DRE-202733:r:Cell surface interactions at the vascular wall", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-GGA-354192:r:Integrin signaling", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-5632681:r:Ligand-receptor interactions", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-8948216:r:Collagen chain trimerization", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-HSA-74713:r:IRS activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-210991:r:Basigin interactions", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-5083633:r:Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-419037:r:NCAM1 interactions", "R-MMU-173736:r:Alternative complement activation", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-1632852:r:Macroautophagy", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-MMU-216083:r:Integrin cell surface interactions", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-BTA-8980692:r:RHOA GTPase cycle", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-416700:r:Other semaphorin interactions", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-170984:r:ARMS-mediated activation", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-354192:r:Integrin signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-HSA-9702620:r:quizartinib-resistant FLT3 mutants", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-BTA-8985947:r:Interleukin-9 signaling", "R-RNO-2172127:r:DAP12 interactions", "R-DME-350054:r:Notch-HLH transcription pathway", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-XTR-5654687:r:Downstream signaling of activated FGFR1", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-GGA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-RNO-74713:r:IRS activation", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-RNO-173736:r:Alternative complement activation", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-MMU-1433559:r:Regulation of KIT signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-9013408:r:RHOG GTPase cycle", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-373756:r:SDK interactions", "R-HSA-2029481:r:FCGR activation", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-BTA-418594:r:G alpha (i) signalling events", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-170968:r:Frs2-mediated activation", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-CFA-2024101:r:CS/DS degradation", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9007892:r:Interleukin-38 signaling", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-8865999:r:MET activates PTPN11", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-CEL-525793:r:Myogenesis", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-5635838:r:Activation of SMO", "R-RNO-9014826:r:Interleukin-36 pathway", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-451927:r:Interleukin-2 family signaling", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9020933:r:Interleukin-23 signaling", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-1236974:r:ER-Phagosome pathway", "R-HSA-5083628:r:Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-376172:r:DSCAM interactions", "R-MMU-416700:r:Other semaphorin interactions", "R-GGA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-114608:r:Platelet degranulation", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-HSA-6809371:r:Formation of the cornified envelope", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-2132295:r:MHC class II antigen presentation", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-HSA-174577:r:Activation of C3 and C5", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DRE-449836:r:Other interleukin signaling", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-8963896:r:HDL assembly", "R-BTA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-1462054:r:Alpha-defensins", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-186797:r:Signaling by PDGF", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2160916:r:Hyaluronan degradation", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-DRE-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-9007892:r:Interleukin-38 signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-GGA-190373:r:FGFR1c ligand binding and activation", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-9702600:r:midostaurin-resistant FLT3 mutants", "R-SSC-8875656:r:MET receptor recycling", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-SSC-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-MMU-210991:r:Basigin interactions", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-912694:r:Regulation of IFNA/IFNB signaling", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-166665:r:Terminal pathway of complement", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-9702632:r:sunitinib-resistant FLT3 mutants", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-HSA-166663:r:Initial triggering of complement", "R-DME-209209:r:Formation of the activated receptor complex", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-449836:r:Other interleukin signaling", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-182971:r:EGFR downregulation", "R-RNO-1566977:r:Fibronectin matrix formation", "R-HSA-2424491:r:DAP12 signaling", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-CFA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-HSA-8983432:r:Interleukin-15 signaling", "R-HSA-164939:r:Nef mediated downregulation of CD28 cell surface expression", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-RNO-174577:r:Activation of C3 and C5", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-GGA-9749641:r:Aspirin ADME", "R-BTA-202433:r:Generation of second messenger molecules", "R-BTA-1236977:r:Endosomal/Vacuolar pathway", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-202433:r:Generation of second messenger molecules", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9664873:r:Pexophagy", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-2024101:r:CS/DS degradation", "R-CEL-373752:r:Netrin-1 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-MMU-3928664:r:Ephrin signaling", "R-SSC-2029481:r:FCGR activation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-376176:r:Signaling by ROBO receptors", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SSC-202424:r:Downstream TCR signaling", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions"], "type": "Homologous_superfamily"}, "IPR013784": {"description": "Carbohydrate-binding-like fold", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "Carb-bd-like_fold", "pathway_ids": ["R-HSA-6798695", "R-HSA-9013405", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-HSA-3785653", "R-MMU-9013404", "R-RNO-9013423", "R-HSA-9013423", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-8980692", "R-HSA-3322077", "R-MMU-6798695", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-9013408", "R-HSA-1483152", "R-HSA-1483115", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-3322077:r:Glycogen synthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-1483152:r:Hydrolysis of LPE", "R-HSA-1483115:r:Hydrolysis of LPC", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR013785": {"description": "Aldolase-type TIM barrel", "go_ids": [], "go_terms": [], "name": "Aldolase_TIM", "pathway_ids": ["R-RNO-500753", "R-HSA-9833482", "R-DRE-196807", "R-SCE-196807", "R-RNO-2142845", "R-RNO-73621", "R-DDI-114608", "R-DDI-189451", "R-SSC-196807", "R-DME-947581", "R-RNO-9033241", "R-BTA-2142845", "R-DME-9857492", "R-MMU-74217", "R-CEL-196807", "R-RNO-73817", "R-DDI-9033241", "R-CEL-71336", "R-MMU-2534343", "R-DDI-6798695", "R-SSC-71336", "R-HSA-6791055", "R-SCE-70171", "R-HSA-500753", "R-MMU-9857492", "R-SPO-500753", "R-RNO-74217", "R-DME-114608", "R-RNO-77111", "R-DME-70171", "R-HSA-70350", "R-HSA-196807", "R-BTA-196780", "R-RNO-389661", "R-DDI-389661", "R-BTA-9857492", "R-DRE-389661", "R-HSA-73621", "R-HSA-389661", "R-DME-70263", "R-RNO-71336", "R-RNO-196807", "R-HSA-9953097", "R-HSA-9748787", "R-HSA-909733", "R-MMU-2024101", "R-BTA-189451", 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"R-MMU-9033241:r:Peroxisomal protein import", "R-CEL-70171:r:Glycolysis", "R-HSA-2160916:r:Hyaluronan degradation", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-HSA-70268:r:Pyruvate metabolism", "R-CEL-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-CEL-70350:r:Fructose catabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-PFA-114608:r:Platelet degranulation", "R-PFA-6798695:r:Neutrophil degranulation", "R-SCE-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-DDI-70350:r:Fructose catabolism", "R-RNO-2160916:r:Hyaluronan degradation", "R-HSA-9033241:r:Peroxisomal protein import", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR013786": {"description": "Acyl-CoA 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"R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-BTA-71064:r:Lysine catabolism", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-71064:r:Lysine catabolism", "R-MMU-6799198:r:Complex I biogenesis", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-BTA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-HSA-9914355:r:Isovaleric acidemia"], "type": "Domain"}, "IPR013787": {"description": "S100/CaBP-9k-type, calcium binding, subdomain", "go_ids": [], "go_terms": [], "name": "S100_Ca-bd_sub", "pathway_ids": ["R-HSA-6798695", "R-HSA-879415", "R-GGA-3000471", "R-GGA-5668599", "R-BTA-6798695", "R-MMU-933542", "R-RNO-3000471", "R-MMU-445989", "R-HSA-6799990", "R-MMU-5668599", "R-SSC-445989", "R-HSA-75205", "R-RNO-5686938", "R-HSA-166058", "R-MMU-5686938", "R-GGA-6798695", "R-BTA-5668599", "R-MMU-6809371", "R-RNO-879415", "R-BTA-933542", "R-RNO-445989", "R-HSA-5603041", "R-HSA-1236974", "R-MMU-6798695", "R-RNO-6798695", "R-RNO-933542", "R-HSA-445989", "R-SSC-6798695", "R-HSA-6809371", "R-HSA-9725554", "R-BTA-879415", "R-MMU-6799990", "R-HSA-933542", "R-HSA-1251985", "R-RNO-6799990", "R-RNO-5668599", "R-HSA-3000471", "R-SSC-933542", "R-BTA-445989", "R-RNO-75205", "R-HSA-5686938", "R-MMU-3000471", "R-BTA-6799990", "R-GGA-75205", "R-MMU-75205", "R-MMU-879415", "R-BTA-5686938", "R-SSC-879415", "R-BTA-75205", "R-HSA-5602498", "R-HSA-5668599"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-GGA-3000471:r:Scavenging by Class B Receptors", "R-GGA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-6799990:r:Metal sequestration by antimicrobial proteins", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-6809371:r:Formation of the cornified envelope", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-BTA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-6799990:r:Metal sequestration by antimicrobial proteins", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-6799990:r:Metal sequestration by antimicrobial proteins", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-BTA-6799990:r:Metal sequestration by antimicrobial proteins", "R-GGA-75205:r:Dissolution of Fibrin Clot", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases"], "type": "Domain"}, "IPR013788": {"description": "Hemocyanin/hexamerin", "go_ids": [], "go_terms": [], "name": "Hemocyanin/hexamerin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013789": {"description": "Phosphotransferase system, mannose family IIA component", "go_ids": ["GO:0005737", "GO:0008643", "GO:0016773"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008643:carbohydrate transport:P", "GO:0016773:phosphotransferase activity, alcohol group as acceptor:F"], "name": "PTS_EIIA_man", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013790": {"description": "SMAD/Dwarfins", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "SMAD/Dwarfins", "pathway_ids": ["R-DME-2173789", "R-MMU-2173795", "R-SSC-2173788", "R-CEL-1181150", "R-MMU-8941326", "R-GGA-8941855", "R-BTA-5689880", "R-HSA-5689880", "R-DME-2173788", "R-HSA-3311021", "R-GGA-9617828", "R-HSA-9617828", "R-DRE-2173795", "R-MMU-5689880", "R-RNO-2173795", "R-HSA-9844594", "R-HSA-9823730", "R-HSA-8941855", "R-SSC-1502540", "R-HSA-9796292", "R-DME-8941855", "R-GGA-2173795", "R-SSC-2173796", "R-DRE-2173789", "R-DRE-201451", "R-HSA-2173789", "R-CEL-2173795", "R-CEL-2173788", "R-GGA-2173796", "R-MMU-2173796", "R-CEL-2173796", "R-HSA-452723", "R-HSA-1502540", "R-RNO-5689880", "R-RNO-8941855", "R-HSA-9008059", "R-HSA-3315487", "R-HSA-9013695", "R-RNO-1502540", "R-HSA-5689603", "R-MMU-2173788", "R-DME-201451", "R-CEL-2173789", "R-MMU-1181150", "R-RNO-2173796", "R-CEL-9617828", "R-SSC-1181150", "R-GGA-2173789", "R-DME-1502540", "R-HSA-9735871", "R-SSC-2173795", "R-BTA-201451", "R-HSA-201451", "R-GGA-1502540", "R-CEL-1502540", "R-RNO-2173788", "R-SSC-2173789", "R-DME-9617828", "R-HSA-8952158", "R-HSA-3656532", "R-SSC-201451", "R-HSA-1181150", "R-HSA-9615017", "R-GGA-1181150", "R-SSC-8941855", "R-HSA-2173795", "R-MMU-201451", "R-CEL-8941855", "R-SSC-5689880", "R-RNO-201451", "R-HSA-8941326", "R-RNO-2173789", "R-HSA-2173796", "R-MMU-8941855", "R-MMU-9617828", "R-MMU-1502540", "R-GGA-2173788", "R-DRE-5689880", "R-MMU-2173789", "R-HSA-9839394", "R-HSA-3304356", "R-SSC-9617828", "R-DRE-2173788", "R-CEL-8941326", "R-DME-2173795", "R-BTA-8941326", "R-CEL-201451", "R-GGA-5689880", "R-CEL-5689880", "R-HSA-9754189", "R-RNO-1181150", "R-HSA-877300", "R-DME-1181150", "R-HSA-9733709", "R-DRE-1502540", "R-DME-8941326", "R-DME-2173796", "R-RNO-9617828", "R-HSA-2173788", "R-DME-5689880", "R-SSC-8941326"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CEL-1181150:r:Signaling by NODAL", "R-MMU-8941326:r:RUNX2 regulates bone development", "R-GGA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-3311021:r:SMAD4 MH2 Domain Mutants in Cancer", "R-GGA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DRE-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9823730:r:Formation of definitive endoderm", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-SSC-1502540:r:Signaling by Activin", "R-HSA-9796292:r:Formation of axial mesoderm", "R-DME-8941855:r:RUNX3 regulates CDKN1A transcription", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DRE-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DRE-201451:r:Signaling by BMP", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-GGA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-1502540:r:Signaling by Activin", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-3315487:r:SMAD2/3 MH2 Domain Mutants in Cancer", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-RNO-1502540:r:Signaling by Activin", "R-HSA-5689603:r:UCH proteinases", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-201451:r:Signaling by BMP", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-1181150:r:Signaling by NODAL", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-SSC-1181150:r:Signaling by NODAL", "R-GGA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-1502540:r:Signaling by Activin", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-SSC-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-GGA-1502540:r:Signaling by Activin", "R-CEL-1502540:r:Signaling by Activin", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SSC-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-SSC-201451:r:Signaling by BMP", "R-HSA-1181150:r:Signaling by NODAL", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-GGA-1181150:r:Signaling by NODAL", "R-SSC-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-201451:r:Signaling by BMP", "R-CEL-8941855:r:RUNX3 regulates CDKN1A transcription", "R-SSC-5689880:r:Ub-specific processing proteases", "R-RNO-201451:r:Signaling by BMP", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-8941855:r:RUNX3 regulates CDKN1A transcription", "R-MMU-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-1502540:r:Signaling by Activin", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-SSC-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CEL-8941326:r:RUNX2 regulates bone development", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-8941326:r:RUNX2 regulates bone development", "R-CEL-201451:r:Signaling by BMP", "R-GGA-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-RNO-1181150:r:Signaling by NODAL", "R-HSA-877300:r:Interferon gamma signaling", "R-DME-1181150:r:Signaling by NODAL", "R-HSA-9733709:r:Cardiogenesis", "R-DRE-1502540:r:Signaling by Activin", "R-DME-8941326:r:RUNX2 regulates bone development", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-SSC-8941326:r:RUNX2 regulates bone development"], "type": "Family"}, "IPR013791": {"description": "RNA 3'-terminal phosphate cyclase, insert domain", "go_ids": [], "go_terms": [], "name": "RNA3'-term_phos_cycl_insert", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR013792": {"description": "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "RNA3'P_cycl/enolpyr_Trfase_a/b", "pathway_ids": ["R-MMU-5689880", "R-MMU-6791226", "R-MTU-964903", "R-SCE-6791226", "R-BTA-6791226", "R-BTA-5689880", "R-HSA-6791226", "R-HSA-5689880", "R-DDI-6791226", "R-DME-6791226", "R-CEL-6791226", "R-HSA-5689603", "R-HSA-2173788", "R-SPO-6791226", "R-HSA-6790901", "R-RNO-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MTU-964903:r:Chorismate via Shikimate Pathway", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-5689603:r:UCH proteinases", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-5689880:r:Ub-specific processing proteases"], "type": "Homologous_superfamily"}, "IPR013795": {"description": "DNA/RNA-binding protein Alba", "go_ids": ["GO:0003677", "GO:0003723"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003723:RNA binding:F"], "name": "DNA/RNA-bd_Alba", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013797": {"description": "Maltooligosyl trehalose synthase, domain 4", "go_ids": [], "go_terms": [], "name": "Maltooligo_trehalose_synth_4", "pathway_ids": ["PWY-2661", "R-MTU-868688"], "pathways": ["PWY-2661:t:trehalose biosynthesis V", 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"R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DME-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-SSC-1266695:r:Interleukin-7 signaling", "R-BTA-8985947:r:Interleukin-9 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-CEL-3249367:r:STAT6-mediated induction of chemokines", "R-MMU-9020956:r:Interleukin-27 signaling", "R-SSC-912694:r:Regulation of IFNA/IFNB signaling", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-9020591:r:Interleukin-12 signaling", "R-CEL-877300:r:Interferon gamma signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-8983432:r:Interleukin-15 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-210671:r:Transcriptional repression by nuclear factors", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-MMU-877312:r:Regulation of IFNG signaling", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-SSC-1059683:r:Interleukin-6 signaling", "R-RNO-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-CEL-9020956:r:Interleukin-27 signaling", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-8849474:r:PTK6 Activates STAT3", "R-DME-8983432:r:Interleukin-15 signaling", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-201556:r:Signaling by ALK", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-CEL-877312:r:Regulation of IFNG signaling", "R-DME-186763:r:Downstream signal transduction", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-RNO-6783783:r:Interleukin-10 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-909733:r:Interferon alpha/beta signaling", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9020956:r:Interleukin-27 signaling", "R-MMU-8875791:r:MET activates STAT3", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-8983432:r:Interleukin-15 signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-BTA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9020558:r:Interleukin-2 signaling", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-DME-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-201556:r:Signaling by ALK", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-CEL-201556:r:Signaling by ALK", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-DME-9020933:r:Interleukin-23 signaling", "R-CEL-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-SSC-186763:r:Downstream signal transduction", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9020933:r:Interleukin-23 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-CEL-9020591:r:Interleukin-12 signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-CEL-9020933:r:Interleukin-23 signaling", "R-BTA-8854691:r:Interleukin-20 family signaling", "R-SSC-8849474:r:PTK6 Activates STAT3", "R-CEL-186763:r:Downstream signal transduction", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-SSC-201556:r:Signaling by ALK", "R-RNO-1059683:r:Interleukin-6 signaling", "R-SSC-6783783:r:Interleukin-10 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-8854691:r:Interleukin-20 family signaling", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-BTA-186763:r:Downstream signal transduction", "R-SSC-8985947:r:Interleukin-9 signaling", "R-DME-8984722:r:Interleukin-35 Signalling", "R-RNO-186763:r:Downstream signal transduction", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-CEL-8985947:r:Interleukin-9 signaling", "R-SSC-9020958:r:Interleukin-21 signaling", "R-DME-9020956:r:Interleukin-27 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-9020591:r:Interleukin-12 signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-9645135:r:STAT5 Activation", "R-RNO-1266695:r:Interleukin-7 signaling", "R-CEL-1059683:r:Interleukin-6 signaling", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-SSC-9008059:r:Interleukin-37 signaling", "R-SSC-9020956:r:Interleukin-27 signaling", "R-DME-909733:r:Interferon alpha/beta signaling", "R-BTA-9020958:r:Interleukin-21 signaling", "R-DME-9008059:r:Interleukin-37 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-877312:r:Regulation of IFNG signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DME-8854691:r:Interleukin-20 family signaling", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DME-9020591:r:Interleukin-12 signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-CEL-8984722:r:Interleukin-35 Signalling", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-SSC-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-8875791:r:MET activates STAT3", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-DME-201556:r:Signaling by ALK", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-9008059:r:Interleukin-37 signaling", "R-RNO-9008059:r:Interleukin-37 signaling"], "type": "Domain"}, "IPR013802": {"description": "Formiminotransferase, C-terminal subdomain", "go_ids": ["GO:0005542", "GO:0016740"], "go_terms": ["GO:0005542:folic acid binding:F", "GO:0016740:transferase activity:F"], "name": "Formiminotransferase_C", "pathway_ids": ["PWY-5030", "PWY-5497", "R-MMU-70921", "R-RNO-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Domain"}, "IPR013803": {"description": "Amyloidogenic glycoprotein, amyloid-beta peptide", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Amyloid_glyco_Abeta", "pathway_ids": ["R-MMU-416476", "R-SSC-432720", "R-HSA-879415", "R-MMU-9837999", "R-MMU-444473", "R-HSA-3000178", "R-HSA-977225", "R-HSA-933542", "R-RNO-444473", "R-SSC-114608", "R-HSA-8862803", "R-HSA-416476", "R-MMU-933542", "R-RNO-9609523", "R-MMU-418594", "R-MMU-8957275", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-MMU-445989", "R-MMU-3000178", "R-RNO-8957275", "R-SSC-933542", "R-MMU-381426", "R-HSA-444473", "R-HSA-9837999", "R-MMU-432720", "R-HSA-9609523", "R-MMU-9609523", "R-SSC-445989", "R-RNO-416476", "R-RNO-3000178", "R-HSA-381426", "R-SSC-3000178", "R-HSA-844456", "R-SSC-381426", "R-SSC-8957275", "R-RNO-432720", "R-HSA-432720", "R-HSA-9660826", "R-MMU-879415", "R-HSA-445989", "R-SSC-9609523", "R-RNO-9837999", "R-SSC-879415", "R-RNO-381426", "R-HSA-418594", "R-RNO-879415", "R-RNO-445989", "R-SSC-9837999", "R-HSA-8957275", "R-RNO-933542", "R-MMU-114608"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-SSC-114608:r:Platelet degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-HSA-844456:r:The NLRP3 inflammasome", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR013805": {"description": "GrpE nucleotide exchange factor, coiled-coil", "go_ids": [], "go_terms": [], "name": "GrpE_CC", "pathway_ids": ["R-HSA-9918481", "R-HSA-1268020"], "pathways": ["R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-1268020:r:Mitochondrial protein import"], "type": "Homologous_superfamily"}, 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"R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-CFA-8875513:r:MET interacts with TNS proteins", "R-GGA-1442490:r:Collagen degradation", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-8875656:r:MET receptor recycling", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-8851805:r:MET activates RAS signaling", "R-CFA-6806942:r:MET Receptor Activation", "R-CFA-8875656:r:MET receptor recycling", "R-MMU-216083:r:Integrin cell surface interactions", "R-GGA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-354192:r:Integrin signaling", 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"R-RNO-8875513:r:MET interacts with TNS proteins", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-8852405:r:Signaling by MST1", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-354192:r:Integrin signaling", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-4086400:r:PCP/CE pathway", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-1442490:r:Collagen degradation", "R-GGA-1566977:r:Fibronectin matrix formation", "R-MMU-6806942:r:MET Receptor Activation", "R-CFA-8865999:r:MET activates PTPN11", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-1442490:r:Collagen degradation", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Homologous_superfamily"}, 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"R-MMU-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-RNO-200425:r:Carnitine shuttle", "R-RNO-71032:r:Propionyl-CoA catabolism", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-CEL-196780:r:Biotin transport and metabolism", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-70635:r:Urea cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-70635:r:Urea cycle", "R-SPO-196780:r:Biotin transport and metabolism", "R-HSA-200425:r:Carnitine shuttle", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-SCE-70635:r:Urea cycle", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR013818": {"description": "Lipase", "go_ids": ["GO:0016298"], "go_terms": ["GO:0016298:lipase activity:F"], "name": "Lipase", "pathway_ids": ["R-RNO-8963901", "R-BTA-8964026", "R-HSA-8963889", "R-RNO-1483166", "R-DME-192456", "R-HSA-8963901", "R-RNO-8964026", "R-HSA-9925561", "R-XTR-1483166", "R-HSA-1483166", "R-HSA-9841922", "R-MMU-975634", "R-DME-8963889", "R-HSA-192456", "R-RNO-8963889", "R-RNO-975634", "R-RNO-1482801", "R-RNO-8964058", "R-MMU-8964058", "R-HSA-8964058", "R-HSA-8964026", "R-HSA-381340", "R-BTA-8963901", "R-MMU-8963889", "R-BTA-8963889", "R-MMU-8964026", "R-MMU-192456", "R-BTA-975634", "R-RNO-192456", "R-MMU-8963901", "R-HSA-1482801", "R-MMU-1483166", "R-DRE-1483166", "R-BTA-192456", "R-GGA-8963889", "R-DRE-1482801", "R-DME-8964058", "R-MMU-1482801", "R-HSA-975634"], "pathways": ["R-RNO-8963901:r:Chylomicron remodeling", "R-BTA-8964026:r:Chylomicron clearance", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-1483166:r:Synthesis of PA", "R-DME-192456:r:Digestion of dietary lipid", "R-HSA-8963901:r:Chylomicron remodeling", "R-RNO-8964026:r:Chylomicron clearance", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-975634:r:Retinoid metabolism and transport", "R-DME-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-192456:r:Digestion of dietary lipid", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-1482801:r:Acyl chain remodelling of PS", "R-RNO-8964058:r:HDL remodeling", "R-MMU-8964058:r:HDL remodeling", "R-HSA-8964058:r:HDL remodeling", "R-HSA-8964026:r:Chylomicron clearance", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-BTA-8963901:r:Chylomicron remodeling", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-BTA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-8964026:r:Chylomicron clearance", "R-MMU-192456:r:Digestion of dietary lipid", "R-BTA-975634:r:Retinoid metabolism and transport", "R-RNO-192456:r:Digestion of dietary lipid", "R-MMU-8963901:r:Chylomicron remodeling", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-MMU-1483166:r:Synthesis of PA", "R-DRE-1483166:r:Synthesis of PA", "R-BTA-192456:r:Digestion of dietary lipid", "R-GGA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-DRE-1482801:r:Acyl chain remodelling of PS", "R-DME-8964058:r:HDL remodeling", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Domain"}, "IPR013819": {"description": "Lipoxygenase, C-terminal", "go_ids": ["GO:0016702", "GO:0046872"], "go_terms": ["GO:0016702:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen:F", "GO:0046872:metal ion binding:F"], "name": "LipOase_C", "pathway_ids": ["R-HSA-6798695", "R-HSA-2142691", "R-HSA-2142700", "R-HSA-9018676", "R-RNO-9023661", "R-MMU-9027604", "R-RNO-2142688", "R-SSC-2142691", "R-MMU-9026286", "R-RNO-9025106", "R-HSA-9023661", "R-MMU-2142688", "R-HSA-9018896", "R-SSC-9025106", "R-SSC-9018681", "R-RNO-9027604", "R-HSA-9018677", "R-HSA-9026290", "R-BTA-2142712", "R-RNO-9018676", "R-MMU-9018676", "R-SSC-2142770", "R-BTA-9018896", "R-MMU-9025106", "R-BTA-2142691", "R-HSA-9026403", "R-RNO-2142770", "R-HSA-6785807", "R-RNO-9026286", "R-BTA-2142770", "R-MMU-2142770", "R-RNO-9018682", "R-SSC-9018677", "R-SSC-9023661", "R-BTA-9026286", "R-HSA-9012546", "R-RNO-9018677", "R-MMU-2142691", "R-HSA-9025106", "R-MMU-6798695", "R-HSA-2142770", "R-MMU-2142712", "R-RNO-6798695", "R-RNO-9018896", "R-BTA-9018681", "R-MMU-9018896", "R-MMU-2142696", "R-HSA-9018681", "R-BTA-9018677", "R-RNO-2142700", "R-MMU-9018681", "R-MMU-9023661", "R-HSA-2142712", "R-RNO-2142712", "R-HSA-2142696", "R-RNO-2142696", "R-HSA-9027604", "R-SSC-9018896", "R-SSC-9026286", "R-MMU-2142700", "R-MMU-9018682", "R-BTA-9023661", "R-MMU-9018677", "R-BTA-9025106", "R-RNO-9026290", "R-HSA-9020265", "R-RNO-9026403", "R-MMU-9026290", "R-HSA-2142688", "R-RNO-2142691", "R-MMU-9026403", "R-MMU-9020265", "R-RNO-9018681", "R-SSC-2142712", "R-HSA-9018682", "R-HSA-9026286", "R-RNO-9020265"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-RNO-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-SSC-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-RNO-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-HSA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SSC-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-SSC-9018681:r:Biosynthesis of protectins", "R-RNO-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-HSA-9018677:r:Biosynthesis of DHA-derived SPMs", "R-HSA-9026290:r:Biosynthesis of DPAn-3-derived maresins", "R-BTA-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-SSC-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9026403:r:Biosynthesis of DPAn-3-derived 13-series resolvins", "R-RNO-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-BTA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-MMU-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-RNO-9018682:r:Biosynthesis of maresins", "R-SSC-9018677:r:Biosynthesis of DHA-derived SPMs", "R-SSC-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-BTA-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-HSA-9012546:r:Interleukin-18 signaling", "R-RNO-9018677:r:Biosynthesis of DHA-derived SPMs", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-MMU-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-BTA-9018681:r:Biosynthesis of protectins", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-2142696:r:Synthesis of Hepoxilins (HX) and Trioxilins (TrX)", "R-HSA-9018681:r:Biosynthesis of protectins", "R-BTA-9018677:r:Biosynthesis of DHA-derived SPMs", "R-RNO-2142700:r:Biosynthesis of Lipoxins (LX)", "R-MMU-9018681:r:Biosynthesis of protectins", "R-MMU-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-HSA-2142696:r:Synthesis of Hepoxilins (HX) and Trioxilins (TrX)", "R-RNO-2142696:r:Synthesis of Hepoxilins (HX) and Trioxilins (TrX)", "R-HSA-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-SSC-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SSC-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-MMU-2142700:r:Biosynthesis of Lipoxins (LX)", "R-MMU-9018682:r:Biosynthesis of maresins", "R-BTA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9018677:r:Biosynthesis of DHA-derived SPMs", "R-BTA-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-RNO-9026290:r:Biosynthesis of DPAn-3-derived maresins", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9026403:r:Biosynthesis of DPAn-3-derived 13-series resolvins", "R-MMU-9026290:r:Biosynthesis of DPAn-3-derived maresins", "R-HSA-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9026403:r:Biosynthesis of DPAn-3-derived 13-series resolvins", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9018681:r:Biosynthesis of protectins", "R-SSC-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-HSA-9018682:r:Biosynthesis of maresins", "R-HSA-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins"], "type": "Domain"}, "IPR013820": {"description": "ATP phosphoribosyltransferase, catalytic domain", "go_ids": ["GO:0000105", "GO:0003879", "GO:0005737"], "go_terms": ["GO:0000105:L-histidine biosynthetic process:P", "GO:0003879:ATP phosphoribosyltransferase activity:F", "GO:0005737:cytoplasm:C"], "name": "ATP_PRibTrfase_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013821": {"description": "Potassium channel, voltage dependent, KCNQ, C-terminal", "go_ids": [], "go_terms": [], "name": "K_chnl_volt-dep_KCNQ_C", "pathway_ids": ["R-HSA-5576890", "R-MMU-5576890", "R-HSA-5576893", "R-BTA-1296072", "R-HSA-9662360", "R-MMU-5576893", "R-HSA-445095", "R-RNO-5576893", "R-HSA-9662361", "R-HSA-1296072", "R-RNO-1296072", "R-MMU-1296072", "R-RNO-5576890"], "pathways": ["R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-MMU-1296072:r:Voltage gated Potassium channels", "R-RNO-5576890:r:Phase 3 - rapid repolarisation"], "type": "Domain"}, "IPR013822": {"description": "Signal recognition particle SRP54, helical bundle", "go_ids": ["GO:0005525", "GO:0006614"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P"], "name": "Signal_recog_particl_SRP54_hlx", "pathway_ids": ["R-HSA-1799339", "R-DRE-1799339", "R-HSA-381038", "R-SPO-1799339", "R-SCE-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-RNO-1799339", "R-BTA-1799339", "R-MMU-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Domain"}, "IPR013823": {"description": "Large ribosomal subunit protein bL12, C-terminal", "go_ids": ["GO:0003735", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0006412:translation:P"], "name": "Ribosomal_bL12_C", "pathway_ids": ["R-BTA-5389840", "R-MMU-9837999", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9837999", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Domain"}, "IPR013824": {"description": "DNA topoisomerase, type IA, central region, subdomain 1", "go_ids": [], "go_terms": [], "name": "Topo_IA_cen_sub1", "pathway_ids": ["R-DDI-5693616", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-DDI-5693607", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR013825": {"description": "DNA topoisomerase, type IA, central region, subdomain 2", "go_ids": [], "go_terms": [], "name": "Topo_IA_cen_sub2", "pathway_ids": ["R-DDI-5693616", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-DDI-5693607", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR013826": {"description": "DNA topoisomerase, type IA, central region, subdomain 3", "go_ids": [], "go_terms": [], "name": "Topo_IA_cen_sub3", "pathway_ids": ["R-DDI-5693616", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-DDI-5693607", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR013828": {"description": "Haemagglutinin, HA1 chain, alpha/beta domain superfamily", "go_ids": ["GO:0019064", "GO:0046789"], "go_terms": ["GO:0019064:fusion of virus membrane with host plasma membrane:P", "GO:0046789:host cell surface receptor binding:F"], "name": "Hemagglutn_HA1_a/b_dom_sf", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168288", "R-HSA-168275", "R-HSA-168316", "R-HSA-198933", "R-HSA-168298", "R-HSA-168874", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-168298:r:Release", "R-HSA-168874:r:Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Homologous_superfamily"}, "IPR013830": {"description": "SGNH hydrolase-type esterase domain", "go_ids": [], "go_terms": [], "name": "SGNH_hydro", "pathway_ids": ["R-RNO-6811436", "R-HSA-6798695", "R-BTA-6811436", "R-DME-6811436", "R-DME-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-HSA-6811436", "R-RNO-6798695", "R-MMU-6811436"], "pathways": ["R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR013833": {"description": "Cytochrome c oxidase, subunit III, 4-helical bundle", "go_ids": ["GO:0004129", "GO:0016020", "GO:0022904"], "go_terms": ["GO:0004129:cytochrome-c oxidase activity:F", "GO:0016020:membrane:C", "GO:0022904:respiratory electron transport chain:P"], "name": "Cyt_c_oxidase_su3_a-hlx", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279", "R-SSC-611105", "R-GGA-9707564", "R-HSA-5419276", "R-SSC-5419276", "R-DRE-611105", "R-DME-9707564", "R-SSC-5628897", "R-DRE-9864848", "R-RNO-5628897", "R-SSC-9864848", "R-RNO-9707564", "R-HSA-5628897", "R-DME-611105", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-GGA-5419276", "R-DME-9864848", "R-SSC-9707564", "R-RNO-5419276", "R-GGA-5628897", "R-HSA-9707564", "R-GGA-611105", "R-MMU-611105", "R-MMU-5628897", "R-MMU-5419276", "R-DME-5419276", "R-MMU-9864848", "R-CEL-5419276", "R-DRE-9707564", "R-DRE-5628897", "R-DME-5628897", "R-MMU-9707564", "R-DRE-5419276"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "R-SSC-611105:r:Respiratory electron transport", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-DRE-611105:r:Respiratory electron transport", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-611105:r:Respiratory electron transport", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-DME-9864848:r:Complex IV assembly", "R-SSC-9707564:r:Cytoprotection by HMOX1", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-GGA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-MMU-9864848:r:Complex IV assembly", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Homologous_superfamily"}, "IPR013834": {"description": "Bacteriophage, G3P, N2-domain superfamily", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Phage_G3P_N2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR013836": {"description": "CD34/Podocalyxin", "go_ids": [], "go_terms": [], "name": "CD34/Podocalyxin", "pathway_ids": ["R-HSA-198933", "R-MMU-156584", "R-MMU-198933", "R-CFA-198933", "R-HSA-156584"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-156584:r:Cytosolic sulfonation of small molecules", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-156584:r:Cytosolic sulfonation of small molecules"], "type": "Family"}, "IPR013837": {"description": "ATP synthase, F0 complex, subunit B", "go_ids": ["GO:0015078", "GO:0015986"], "go_terms": ["GO:0015078:proton transmembrane transporter activity:F", "GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_F0_suB", "pathway_ids": ["R-BTA-8949613", "R-CEL-163210", "R-MMU-163210", "R-DME-8949613", "R-BTA-163210", "R-CEL-8949613", "R-RNO-163210", "R-DME-163210", "R-RNO-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-BTA-8949613:r:Cristae formation", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-8949613:r:Cristae formation", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR013839": {"description": "NAD-dependent DNA ligase, adenylation", "go_ids": ["GO:0003911"], "go_terms": ["GO:0003911:DNA ligase (NAD+) activity:F"], "name": "DNAligase_adenylation", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013840": {"description": "NAD-dependent DNA ligase, N-terminal", "go_ids": ["GO:0003911"], "go_terms": ["GO:0003911:DNA ligase (NAD+) activity:F"], "name": "DNAligase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013842": {"description": "GTP-binding protein LepA, C-terminal", "go_ids": [], "go_terms": [], "name": "LepA_CTD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013843": {"description": "Small ribosomal subunit protein eS4, N-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_eS4_N", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-HSA-72695", "R-RNO-72695", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-CEL-72706", "R-BTA-72695", "R-CEL-9954714", "R-CEL-9954716", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-SPO-975956", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-BTA-6791226", "R-SPO-72706", "R-DRE-9954714", "R-SCE-975956", "R-DDI-72695", "R-DRE-72695", "R-CEL-1799339", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-CEL-156827", "R-RNO-72649", "R-RNO-6791226", "R-DRE-1799339", "R-HSA-6791226", "R-RNO-975956", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-SPO-72689", "R-DDI-72689", "R-DDI-72702", "R-MMU-1799339", "R-CEL-72689", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-72695", "R-MMU-72702", "R-DME-975956", "R-BTA-9954716", "R-DRE-975956", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-HSA-72649", "R-MMU-156827", "R-HSA-9754678", "R-BTA-1799339", "R-BTA-9954714", "R-SPO-6791226", "R-DRE-72649", "R-SCE-72649", "R-HSA-975957", "R-DRE-72702", "R-DME-9954714", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-156827:r:L13a-mediated translational silencing of 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deficiency"], "type": "Domain"}, "IPR013846": {"description": "mRNA capping enzyme, C-terminal domain", "go_ids": [], "go_terms": [], "name": "mRNA_cap_enzyme_C", "pathway_ids": ["PWY-7375", "R-SPO-77075", "R-MMU-77075", "R-SCE-77075", "R-HSA-167160", "R-SCE-72086", "R-DRE-72086", "R-HSA-77075", "R-MMU-72086", "R-HSA-72086", "R-SPO-72086", "R-CEL-72086", "R-CEL-77075", "R-DRE-77075"], "pathways": ["PWY-7375:t:mRNA capping I", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-SPO-72086:r:mRNA Capping", "R-CEL-72086:r:mRNA Capping", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE"], "type": "Domain"}, "IPR013848": {"description": "Methylthiotransferase, N-terminal", "go_ids": ["GO:0051539", "GO:0035596"], "go_terms": ["GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0035596:methylthiotransferase activity:F"], "name": "Methylthiotransferase_N", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR013849": {"description": "DNA helicase, Holliday junction RuvA type, domain I, bacterial", "go_ids": ["GO:0005524", "GO:0006281", "GO:0006310", "GO:0009378"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0009378:four-way junction helicase activity:F"], "name": "DNA_helicase_Holl-junc_RuvA_I", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013851": {"description": "Transcription factor Otx, C-terminal", "go_ids": ["GO:0003700", "GO:0005634", "GO:0007275"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C", "GO:0007275:multicellular organism development:P"], "name": "Otx_TF_C", "pathway_ids": ["R-HSA-9832991", "R-HSA-9823739"], "pathways": ["R-HSA-9832991:r:Formation of the posterior neural plate", "R-HSA-9823739:r:Formation of the anterior neural plate"], "type": "Domain"}, "IPR013853": {"description": "Galactitol permease IIC component", "go_ids": ["GO:0015796", "GO:0015577"], "go_terms": ["GO:0015796:galactitol transmembrane transport:P", "GO:0015577:galactitol transmembrane transporter activity:F"], "name": "EIIC-GAT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013854": {"description": "Transcription factor AP-2, C-terminal", "go_ids": [], "go_terms": [], "name": "TF_AP2_C", "pathway_ids": ["R-CFA-8866904", "R-BTA-8869496", "R-RNO-8864260", "R-HSA-8866904", "R-BTA-8866907", "R-CEL-9834899", "R-MMU-8869496", "R-HSA-9764790", "R-HSA-8864260", "R-CFA-8866907", "R-HSA-9827857", "R-HSA-8869496", "R-RNO-8866904", "R-MMU-8866911", "R-HSA-8866906", "R-DRE-8866907", "R-HSA-8866910", "R-RNO-8869496", "R-MMU-3232118", "R-CEL-8866907", "R-HSA-9938206", "R-HSA-9834899", "R-RNO-9834899", "R-HSA-8866911", "R-HSA-8866907", "R-CEL-8866904", "R-BTA-9834899", "R-CEL-3232118", "R-MMU-8866907", "R-MMU-8864260", "R-HSA-9824585", "R-RNO-8866907", "R-HSA-3232118", "R-MMU-9834899", "R-MMU-8866904", "R-BTA-8864260", "R-CFA-9834899", "R-BTA-8866904"], "pathways": ["R-CFA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-BTA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-HSA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-BTA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-CEL-9834899:r:Specification of the neural plate border", "R-MMU-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-HSA-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-CFA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9827857:r:Specification of primordial germ cells", "R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-MMU-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-8866906:r:TFAP2 (AP-2) family regulates transcription of other transcription factors", "R-DRE-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-RNO-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-CEL-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-9834899:r:Specification of the neural plate border", "R-RNO-9834899:r:Specification of the neural plate border", "R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-CEL-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-BTA-9834899:r:Specification of the neural plate border", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-9834899:r:Specification of the neural plate border", "R-MMU-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-BTA-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-CFA-9834899:r:Specification of the neural plate border", "R-BTA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "type": "Domain"}, "IPR013855": {"description": "Cdc37, N-terminal domain", "go_ids": ["GO:0019901"], "go_terms": ["GO:0019901:protein kinase binding:F"], "name": "Cdc37_N_dom", "pathway_ids": ["R-MMU-8863795", "R-CEL-8863795", "R-CEL-1227986", "R-HSA-9013418", "R-CEL-9652282", "R-HSA-9665251", "R-BTA-1227986", "R-BTA-9652282", "R-DME-9652282", "R-HSA-9665737", "R-SCE-114608", "R-HSA-9665348", "R-SPO-114608", "R-HSA-9665245", "R-RNO-8863795", "R-HSA-8863795", "R-BTA-5675482", "R-HSA-1236382", "R-MMU-9652282", "R-BTA-9013418", "R-DME-8863795", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-9652282", "R-BTA-8863795", "R-RNO-9013418", "R-DME-1227986", "R-HSA-9665244", "R-HSA-9665686", "R-HSA-9665249", "R-HSA-9665246", "R-HSA-5675482", "R-DME-114608", "R-MMU-1227986", "R-HSA-1227986", "R-CEL-114608", "R-HSA-9665233", "R-MMU-5675482", "R-RNO-1227986", "R-HSA-9665250", "R-HSA-5637810", "R-DME-9013418", "R-SPO-9652282", "R-CEL-5675482", "R-HSA-9634285", "R-RNO-9652282", "R-RNO-5675482", "R-MMU-9013418"], "pathways": ["R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-1227986:r:Signaling by ERBB2", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-CEL-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-BTA-1227986:r:Signaling by ERBB2", "R-BTA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-SCE-114608:r:Platelet degranulation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-SPO-114608:r:Platelet degranulation", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-DME-114608:r:Platelet degranulation", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-1227986:r:Signaling by ERBB2", "R-CEL-114608:r:Platelet degranulation", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-CEL-5675482:r:Regulation of necroptotic cell death", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-9013418:r:RHOBTB2 GTPase cycle"], "type": "Domain"}, "IPR013856": {"description": "Peptidase M4 domain", "go_ids": ["GO:0004222"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F"], "name": "Peptidase_M4_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013857": {"description": "NADH:ubiquinone oxidoreductase intermediate-associated protein 30", "go_ids": [], "go_terms": [], "name": "NADH-UbQ_OxRdtase-assoc_prot30", "pathway_ids": ["R-MMU-6799198", "R-DME-6799198", "R-HSA-6799198"], "pathways": ["R-MMU-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis"], "type": "Domain"}, "IPR013858": {"description": "Peptidase M10 serralysin, C-terminal", "go_ids": ["GO:0005509", "GO:0005576"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0005576:extracellular region:C"], "name": "Peptidase_M10B_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013859": {"description": "SWI/SNF and RSC complexes subunit Ssr4, N-terminal", "go_ids": ["GO:0006338"], "go_terms": ["GO:0006338:chromatin remodeling:P"], "name": "Ssr4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013860": {"description": "Nitrogen regulatory protein areA, GATA-like domain", "go_ids": [], "go_terms": [], "name": "AreA_GATA", "pathway_ids": ["R-SCE-9018519", "R-SPO-9018519"], "pathways": ["R-SCE-9018519:r:Estrogen-dependent gene expression", "R-SPO-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR013861": {"description": "TMEM115/Pdh1/Rbl19", "go_ids": ["GO:0016020", "GO:0006890"], "go_terms": ["GO:0016020:membrane:C", "GO:0006890:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum:P"], "name": "TMEM115/Pdh1/Rbl19", "pathway_ids": ["R-HSA-6807878", "R-BTA-6807878", "R-MMU-6807878"], "pathways": ["R-HSA-6807878:r:COPI-mediated anterograde transport", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport"], "type": "Family"}, "IPR013862": {"description": "Inositolphosphorylceramide synthase subunit Kei1", "go_ids": ["GO:0006673", "GO:0070917"], "go_terms": ["GO:0006673:inositol phosphoceramide metabolic process:P", "GO:0070917:inositol phosphoceramide synthase regulator activity:F"], "name": "Kei1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013863": {"description": "Vacuolar import/degradation Vid27, C-terminal", "go_ids": [], "go_terms": [], "name": "VID27_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013865": {"description": "Protein FAM32A", "go_ids": [], "go_terms": [], "name": "FAM32A", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-XTR-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR013866": {"description": "Sphingolipid delta4-desaturase, N-terminal", "go_ids": [], "go_terms": [], "name": "Sphingolipid_d4-desaturase_N", "pathway_ids": ["PWY-5129", "R-HSA-6798695", "R-SPO-6798695", "R-BTA-1660661", "R-XTR-1660661", "R-DME-6798695", "R-CEL-6798695", "R-DME-1660661", "R-RNO-1660661", "R-MMU-6798695", "R-BTA-6798695", "R-CEL-1660661", "R-HSA-1660661", "R-XTR-6798695", "R-GGA-433584", "R-GGA-6798695", "R-RNO-6798695", "R-GGA-1660661", "R-MMU-1660661"], "pathways": ["PWY-5129:t:sphingolipid biosynthesis (plants)", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-XTR-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-XTR-6798695:r:Neutrophil degranulation", "R-GGA-433584:r:Sphingolipid metabolism", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-GGA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Domain"}, "IPR013867": {"description": "Telomere repeat-binding factor, dimerisation domain", "go_ids": ["GO:0042162", "GO:0042803"], "go_terms": ["GO:0042162:telomeric repeat DNA binding:F", "GO:0042803:protein homodimerization activity:F"], "name": "Telomere_rpt-bd_fac_dimer_dom", "pathway_ids": ["R-MMU-174430", "R-HSA-174414", "R-MMU-174417", "R-HSA-1221632", "R-MMU-110331", "R-MMU-9670095", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-MMU-110330", "R-HSA-171306", "R-MMU-2559586", "R-HSA-174430", "R-HSA-110328", "R-HSA-174411", "R-MMU-171319", "R-HSA-9670095", "R-GGA-418124", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-GGA-418124:r:Telomere maintenance", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Domain"}, "IPR013868": {"description": "Tethering factor for nuclear proteasome Cut8/Sts1", "go_ids": ["GO:0031144", "GO:0005634", "GO:0071630"], "go_terms": ["GO:0031144:proteasome localization:P", "GO:0005634:nucleus:C", "GO:0071630:nuclear protein quality control by the ubiquitin-proteasome system:P"], "name": "Cut8/Sts1_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013869": {"description": "Protein of unknown function DUF1757", "go_ids": [], "go_terms": [], "name": "DUF1757", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013870": {"description": "Large ribosomal subunit protein mL54", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL54", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-DRE-5389840", "R-MMU-5389840", "R-DRE-5419276"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR013871": {"description": "Cysteine-rich secretory protein", "go_ids": [], "go_terms": [], "name": "Cysteine_rich_secretory", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR013872": {"description": "p53, transactivation domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "p53_transactivation_domain", "pathway_ids": ["R-HSA-6804115", "R-HSA-2559580", "R-HSA-9833482", "R-HSA-5689896", "R-HSA-5689880", "R-BTA-5689880", "R-MMU-69895", "R-RNO-5693565", "R-SSC-2559586", "R-MMU-6804756", "R-HSA-5693565", "R-HSA-6796648", "R-MMU-2559584", "R-MMU-5689896", "R-MMU-69481", "R-MMU-69541", "R-BTA-6804757", "R-HSA-139915", "R-HSA-6804759", "R-MMU-69473", "R-MMU-5689880", "R-MMU-9833482", "R-BTA-6804754", "R-BTA-6804759", "R-SSC-9833482", "R-BTA-6804756", "R-RNO-6811555", "R-SSC-2559584", "R-HSA-6804754", "R-HSA-6804757", "R-HSA-8941855", "R-HSA-8943724", "R-BTA-69481", "R-SSC-69481", "R-MMU-6804760", "R-HSA-69481", "R-BTA-2559580", "R-HSA-9723905", "R-HSA-69473", "R-MMU-2559586", "R-HSA-983231", "R-HSA-9758274", "R-RNO-6804754", "R-BTA-5693565", "R-HSA-6785807", "R-HSA-6804760", "R-MMU-2559580", "R-RNO-6804760", "R-RNO-5689880", "R-RNO-69473", 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ERBB2 signaling", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR013875": {"description": "Mitochondrial import protein Pam17", "go_ids": ["GO:0001405"], "go_terms": ["GO:0001405:PAM complex, Tim23 associated import motor:C"], "name": "Pam17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013876": {"description": "TFIIH p62 subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "TFIIH_BTF_p62_N", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DME-6781823", "R-DME-76042", "R-MMU-113418", "R-HSA-427413", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-SPO-5696395", "R-SPO-76042", "R-HSA-167246", "R-HSA-73776", "R-MMU-5696395", "R-DME-72086", "R-DDI-674695", "R-HSA-75953", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-DME-75953", "R-MMU-73779", "R-DME-6782135", "R-MMU-76042", "R-SPO-75953", "R-SPO-113418", "R-DDI-73779", "R-DME-674695", "R-DDI-6781823", "R-DDI-72086", "R-MMU-674695", "R-SCE-76042", "R-HSA-167161", "R-DME-112382", "R-HSA-167200", "R-SCE-674695", "R-HSA-5696395", "R-HSA-167160", "R-DDI-77075", "R-SPO-73779", "R-DDI-113418", "R-MMU-73772", "R-MMU-72086", "R-MMU-6782210", "R-SPO-73776", "R-DME-73772", "R-SCE-73776", "R-SCE-6782135", "R-DDI-6782135", "R-MMU-73762", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-DME-6796648", "R-HSA-72086", "R-DME-77075", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-MMU-6781823", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-SCE-6782210", "R-HSA-167172", "R-MMU-5696400", "R-SCE-6796648", "R-SCE-73779", "R-DME-113418", "R-SPO-77075", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-SCE-6781823", "R-MMU-73863", "R-HSA-6782135", "R-DME-5696395", "R-HSA-73762", "R-HSA-73863", "R-SPO-73772", "R-SPO-5696400", "R-HSA-75955", "R-SCE-77075", "R-SPO-6782210", "R-DME-5696400", "R-MMU-77075", "R-HSA-5696400", "R-DME-6782210", "R-HSA-76042", "R-SPO-6782135", "R-HSA-674695", "R-SCE-73772", "R-DDI-75953", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-72086:r:mRNA Capping", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72086:r:mRNA Capping", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR013877": {"description": "YAP-binding/ALF4/Glomulin", "go_ids": [], "go_terms": [], "name": "YAP-bd/ALF4/Glomulin", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR013878": {"description": "Mo25-like", "go_ids": [], "go_terms": [], "name": "Mo25", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-MMU-380972", "R-DME-6798695", "R-CEL-6798695", "R-SCE-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-HSA-380972", "R-BTA-380972"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK"], "type": "Family"}, "IPR013879": {"description": "Protein of unknown function DUF1761", "go_ids": [], "go_terms": [], "name": "DUF1761", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013880": {"description": "Yos1-like", "go_ids": [], "go_terms": [], "name": "Yos1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013881": {"description": "Pre-mRNA-splicing factor 3 domain", "go_ids": [], "go_terms": [], "name": "Pre-mRNA_splic_Prp3_dom", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR013882": {"description": "DNA endonuclease activator Ctp1, C-terminal", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "Ctp1_C", "pathway_ids": ["R-DRE-5693607", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5685939", "R-MMU-6804756", "R-DRE-5685939", "R-MMU-5693616", "R-HSA-8953750", "R-MMU-5685938", "R-MMU-69473", "R-DRE-5693568", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-5685938", "R-HSA-912446", "R-MMU-5685939", "R-RNO-6804756", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-RNO-5693579", "R-HSA-69473", "R-RNO-5693607", "R-MMU-5685942", "R-DRE-5685942", "R-HSA-9709603", "R-HSA-5685939", "R-RNO-69473", "R-RNO-5685942", "R-HSA-6804756", "R-DRE-69473", "R-HSA-9704331", "R-RNO-5693568", "R-DRE-5693616", "R-RNO-5693616", "R-HSA-5693554", "R-HSA-5693579", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR013883": {"description": "Transcription factor Iwr1 domain", "go_ids": [], "go_terms": [], "name": "TF_Iwr1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013885": {"description": "Protein of unknown function DUF1764, eukaryotic", "go_ids": [], "go_terms": [], "name": "DUF1764_euk", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013886": {"description": "PI31 proteasome regulator, C-terminal", "go_ids": [], "go_terms": [], "name": "PI31_Prot_C", "pathway_ids": ["R-HSA-9907900"], "pathways": ["R-HSA-9907900:r:Proteasome assembly"], "type": "Domain"}, "IPR013887": {"description": "Uncharacterised protein family UPF0592", "go_ids": [], "go_terms": [], "name": "UPF0592", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013888": {"description": "Ribonuclease P, Rpm2, mitochondrial", "go_ids": [], "go_terms": [], "name": "RNase_P_Rpm2_mt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013889": {"description": "Karyogamy protein, KAR9", "go_ids": [], "go_terms": [], "name": "Karyogamy_KAR9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013890": {"description": "Transcriptional repressor Tup1, N-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt_rep_Tup1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013892": {"description": "Cytochrome c oxidase biogenesis protein Cmc1-like", "go_ids": [], "go_terms": [], "name": "Cyt_c_biogenesis_Cmc1-like", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848", "R-HSA-1268020", "R-BTA-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR013893": {"description": "Ribonuclease P protein subunit Rpp40", "go_ids": ["GO:0001682", "GO:0030677"], "go_terms": ["GO:0001682:tRNA 5'-leader removal:P", "GO:0030677:ribonuclease P complex:C"], "name": "RNase_P_Rpp40", "pathway_ids": ["R-MMU-6791226", "R-HSA-6784531", "R-SPO-6791226", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR013894": {"description": "RecQ mediated genome instability protein 1, OB-fold domain", "go_ids": [], "go_terms": [], "name": "RMI1_OB", "pathway_ids": ["R-DRE-5693607", "R-BTA-69473", "R-BTA-5685938", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-DRE-5693568", "R-HSA-9709570", "R-HSA-5693607", "R-BTA-6804756", "R-BTA-5693616", "R-BTA-5693579", "R-BTA-5693607", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-BTA-5693568", "R-HSA-69473", "R-MMU-5685942", "R-DRE-5685942", "R-HSA-9709603", "R-HSA-6804756", "R-DRE-69473", "R-HSA-9704331", "R-BTA-5685942", "R-DRE-5693616", "R-HSA-5693554", "R-HSA-5693579", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR013895": {"description": "Chromatin structure-remodeling complex protein Rsc14", "go_ids": ["GO:0006338", "GO:0016586"], "go_terms": ["GO:0006338:chromatin remodeling:P", "GO:0016586:RSC-type complex:C"], "name": "Rsc14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013896": {"description": "Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "SNF1_UBA", "pathway_ids": ["R-SCE-1632852", "R-SCE-380972", "R-SPO-200425", "R-SPO-5628897", "R-SPO-380972", "R-SPO-163680", "R-SPO-1632852", "R-SCE-200425", "R-SCE-163680"], "pathways": ["R-SCE-1632852:r:Macroautophagy", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-200425:r:Carnitine shuttle", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-SPO-1632852:r:Macroautophagy", "R-SCE-200425:r:Carnitine shuttle", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity"], "type": "Domain"}, "IPR013897": {"description": "Domain of unknown function at the cortex 1", "go_ids": [], "go_terms": [], "name": "Duc1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013898": {"description": "Mitophagy receptor Atg43", "go_ids": ["GO:0140580", "GO:0000423"], "go_terms": ["GO:0140580:mitochondrion autophagosome adaptor activity:F", "GO:0000423:mitophagy:P"], "name": "Atg43", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013899": {"description": "Domain of unknown function DUF1771", "go_ids": [], "go_terms": [], "name": "DUF1771", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013900": {"description": "Ribonucleotide reductase inhibitor", "go_ids": [], "go_terms": [], "name": "RNR_inhibitor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013901": {"description": "Anthrone oxygenase", "go_ids": [], "go_terms": [], "name": "MdpH-2", "pathway_ids": ["PWY-5787", "PWY-5780", "PWY-5399", "PWY-7079", "PWY-5476", "PWY-5439", "PWY-5404"], "pathways": ["PWY-5787:t:oligomeric urushiol biosynthesis", "PWY-5780:t:hypericin biosynthesis", "PWY-5399:t:betacyanin biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-5476:t:cornusiin E biosynthesis", "PWY-5439:t:betacyanin biosynthesis (via dopamine)", "PWY-5404:t:betaxanthin biosynthesis (via dopaxanthin)"], "type": "Family"}, "IPR013902": {"description": "Mug135-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Mug135-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013903": {"description": "Meiotic expression up-regulated protein", "go_ids": [], "go_terms": [], "name": "Meiotic_expression", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013904": {"description": "Transcriptional regulatory protein RXT2, N-terminal", "go_ids": [], "go_terms": [], "name": "RXT2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013905": {"description": "Lethal giant larvae (Lgl)-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Lgl_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013906": {"description": "Eukaryotic translation initiation factor 3 subunit J", "go_ids": ["GO:0003743", "GO:0005737", "GO:0005852"], "go_terms": ["GO:0003743:translation initiation factor activity:F", "GO:0005737:cytoplasm:C", "GO:0005852:eukaryotic translation initiation factor 3 complex:C"], "name": "eIF3j", "pathway_ids": ["R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-DME-72649", "R-HSA-156827", "R-XTR-72702", "R-RNO-72689", "R-GGA-72702", "R-MMU-72649", "R-HSA-72695", "R-RNO-72695", "R-BTA-72689", "R-MMU-72706", "R-SPO-72689", "R-BTA-72695", "R-SCE-72695", "R-MMU-72695", "R-SCE-72702", "R-XTR-72695", "R-DRE-156827", "R-SCE-156827", "R-BTA-156827", "R-MMU-72702", "R-DME-72695", "R-RNO-156827", "R-DRE-72695", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-XTR-156827", "R-BTA-72702", "R-DME-72689", "R-RNO-72702", "R-HSA-72706", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-RNO-72649", "R-GGA-72649", "R-DRE-72649", "R-SCE-72649", "R-DRE-72702", "R-DRE-72689", "R-SPO-156827", "R-DME-72702", "R-BTA-72649", "R-GGA-72695", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": 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and subsequently, the 43S complex", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-GGA-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-GGA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Family"}, "IPR013907": {"description": "Sds3-like", "go_ids": [], "go_terms": [], "name": "Sds3", "pathway_ids": ["R-MMU-5689880", "R-SPO-3214815", "R-BTA-3214815", "R-HSA-5689880", "R-HSA-427413", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-SCE-3214815", "R-RNO-3214815"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-SPO-3214815:r:HDACs deacetylate histones", "R-BTA-3214815:r:HDACs deacetylate histones", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SCE-3214815:r:HDACs deacetylate histones", "R-RNO-3214815:r:HDACs deacetylate histones"], "type": "Family"}, "IPR013908": {"description": "Nibrin, C-terminal", "go_ids": [], "go_terms": [], "name": "Nibrin_C", "pathway_ids": ["R-DRE-5693607", "R-HSA-5685942", "R-MMU-5693571", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5693565", "R-GGA-351433", "R-RNO-5685939", "R-MMU-6804756", "R-HSA-5693565", "R-DRE-5685939", "R-RNO-5693548", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-5693565", "R-MMU-69473", "R-DRE-5693568", "R-DRE-5693571", "R-HSA-9709570", "R-HSA-5693607", "R-DRE-2559586", "R-GGA-351444", "R-RNO-5685938", "R-HSA-912446", "R-MMU-5685939", "R-RNO-6804756", "R-MMU-5693568", "R-GGA-351442", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-RNO-2559586", "R-GGA-217106", "R-MMU-5693548", "R-RNO-5693579", "R-HSA-69473", "R-MMU-2559586", "R-RNO-5693607", "R-HSA-9709603", "R-DRE-5685942", "R-MMU-5685942", "R-RNO-5693571", "R-HSA-5685939", "R-RNO-69473", "R-RNO-5685942", "R-DRE-5693548", "R-HSA-5693571", "R-HSA-6804756", "R-HSA-9704331", "R-DRE-69473", "R-RNO-5693568", "R-DRE-5693616", "R-DRE-5693565", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-HSA-5693579", "R-HSA-2559586", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR013909": {"description": "NuBaID, C-terminal domain", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "NuBaID_C", "pathway_ids": ["R-HSA-9725371"], "pathways": ["R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer"], "type": "Domain"}, "IPR013910": {"description": "Transcription factor PAP1", "go_ids": [], "go_terms": [], "name": "TF_PAP1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013911": {"description": "Mitochondrial inner membrane i-AAA protease complex subunit Mgr1", "go_ids": ["GO:0005743"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C"], "name": "i-AAA_Mgr1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013912": {"description": "Adenylate cyclase-associated CAP, C-terminal", "go_ids": ["GO:0003779", "GO:0007010"], "go_terms": ["GO:0003779:actin binding:F", "GO:0007010:cytoskeleton organization:P"], "name": "Adenylate_cyclase-assoc_CAP_C", "pathway_ids": ["R-DDI-6798695", "R-HSA-114608", "R-SPO-6798695", "R-HSA-6798695", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-428890", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR013913": {"description": "Nucleoporin Nup153, N-terminal", "go_ids": [], "go_terms": [], "name": "Nup153_N", "pathway_ids": ["R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-MMU-3301854", "R-HSA-4085377", "R-HSA-168325", "R-MMU-170822", "R-HSA-9609690", "R-RNO-159227", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-RNO-4551638", "R-MMU-159227", "R-RNO-4085377", "R-RNO-170822", "R-HSA-5619107", "R-RNO-159231", "R-RNO-4570464", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-MMU-4570464", "R-RNO-3301854", "R-RNO-3108214", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-159230", "R-HSA-159227", "R-HSA-159230", "R-MMU-4085377", "R-MMU-4551638", "R-HSA-168333", "R-RNO-159230", "R-HSA-3371453", "R-RNO-191859", "R-HSA-165054", "R-HSA-4570464", "R-RNO-159236"], "pathways": ["R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-191859:r:snRNP Assembly", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR013914": {"description": "Rad9-like Rad53-binding domain, fungi", "go_ids": [], "go_terms": [], "name": "Rad9_Rad53-bd_dom_fun", "pathway_ids": ["R-SCE-3232118"], "pathways": ["R-SCE-3232118:r:SUMOylation of transcription factors"], "type": "Domain"}, "IPR013915": {"description": "Prp19, coiled-coil region", "go_ids": [], "go_terms": [], "name": "Prp19_cc", "pathway_ids": ["PWY-7511", "R-DDI-6782135", "R-RNO-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-72163", "R-BTA-6782135", "R-RNO-6782135", "R-DDI-6781823", "R-RNO-72163", "R-DDI-6782210", "R-HSA-6782135", "R-CEL-6782210", "R-DDI-72163", "R-HSA-6781823", "R-CEL-6781823", "R-RNO-6782210", "R-HSA-72163", "R-BTA-6781823", "R-MMU-6781823", "R-SPO-6782210", "R-CEL-6782135", "R-HSA-6782210", "R-BTA-6782210", "R-MMU-6782210", "R-SPO-6782135", "R-CEL-72163", "R-SCE-6782210", "R-SPO-72163", "R-HSA-9918481", "R-SCE-6782135", "R-BTA-72163"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6782135:r:Dual incision in TC-NER", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-6782135:r:Dual incision in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR013917": {"description": "tRNA wybutosine-synthesis", "go_ids": [], "go_terms": [], "name": "tRNA_wybutosine-synth", "pathway_ids": ["PWY-7286", "PWY-7285", "R-HSA-6782861"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)"], "type": "Domain"}, "IPR013918": {"description": "Nucleotide exchange factor Fes1", "go_ids": [], "go_terms": [], "name": "Nucleotide_exch_fac_Fes1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013919": {"description": "Peroxisome membrane protein, Pex16", "go_ids": [], "go_terms": [], "name": "Pex16", "pathway_ids": ["R-DDI-9603798", "R-MMU-9603798", "R-HSA-9603798", "R-BTA-9603798", "R-SPO-9603798", "R-DRE-9603798"], "pathways": ["R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-DRE-9603798:r:Class I peroxisomal membrane protein import"], "type": "Family"}, "IPR013920": {"description": "Protein of unknown function DUF1774, fungi", "go_ids": [], "go_terms": [], "name": "DUF1774_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013921": {"description": "Mediator complex, subunit Med20", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med20", "pathway_ids": ["R-RNO-9841922", "R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR013922": {"description": "Cyclin PHO80-like", "go_ids": ["GO:0000079", "GO:0019901"], "go_terms": ["GO:0000079:regulation of cyclin-dependent protein serine/threonine kinase activity:P", "GO:0019901:protein kinase binding:F"], "name": "Cyclin_PHO80-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013923": {"description": "Autophagy-related protein 16 domain", "go_ids": [], "go_terms": [], "name": "Autophagy-rel_prot_16_dom", "pathway_ids": ["R-DDI-1632852", "R-MMU-1632852", "R-XTR-1632852", "R-HSA-1632852"], "pathways": ["R-DDI-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy"], "type": "Domain"}, "IPR013924": {"description": "Ribonuclease H2, subunit C", "go_ids": ["GO:0032299", "GO:0006401"], "go_terms": ["GO:0032299:ribonuclease H2 complex:C", "GO:0006401:RNA catabolic process:P"], "name": "RNase_H2_suC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013926": {"description": "CGI121/TPRKB", "go_ids": [], "go_terms": [], "name": "CGI121/TPRKB", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR013927": {"description": "Transcription factor Opi1/Ccg-8", "go_ids": ["GO:0003714"], "go_terms": ["GO:0003714:transcription corepressor activity:F"], "name": "TF_Opi1_Ccg-8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013928": {"description": "Alkali metal cation/H+ antiporter Nha1, C-terminal", "go_ids": ["GO:0006814", "GO:0015385", "GO:0016020"], "go_terms": ["GO:0006814:sodium ion transport:P", "GO:0015385:sodium:proton antiporter activity:F", "GO:0016020:membrane:C"], "name": "Cation/H_antiporter_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013929": {"description": "RPAP1, C-terminal", "go_ids": [], "go_terms": [], "name": "RPAP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013930": {"description": "RPAP1, N-terminal", "go_ids": [], "go_terms": [], "name": "RPAP1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013931": {"description": "Svf1-like, N-terminal", "go_ids": ["GO:0006979"], "go_terms": ["GO:0006979:response to oxidative stress:P"], "name": "Svf1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013932": {"description": "TATA-binding protein interacting (TIP20)", "go_ids": [], "go_terms": [], "name": "TATA-bd_TIP120", "pathway_ids": ["R-DDI-6798695", "R-BTA-8951664", "R-CEL-917937", "R-HSA-6798695", "R-SPO-6798695", "R-RNO-917937", "R-DDI-917937", "R-CEL-6798695", "R-HSA-8951664", "R-DME-6798695", "R-DME-8951664", "R-BTA-6798695", "R-DDI-8951664", "R-MMU-8951664", "R-MMU-917937", "R-BTA-917937", "R-RNO-8951664", "R-HSA-917937", "R-SPO-917937", "R-MMU-6798695", "R-SPO-8951664", "R-DME-917937", "R-RNO-6798695", "R-CEL-8951664"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-8951664:r:Neddylation", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-917937:r:Iron uptake and transport", "R-DDI-917937:r:Iron uptake and transport", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-8951664:r:Neddylation", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-8951664:r:Neddylation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-MMU-917937:r:Iron uptake and transport", "R-BTA-917937:r:Iron uptake and transport", "R-RNO-8951664:r:Neddylation", "R-HSA-917937:r:Iron uptake and transport", "R-SPO-917937:r:Iron uptake and transport", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-8951664:r:Neddylation", "R-DME-917937:r:Iron uptake and transport", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR013933": {"description": "Chromatin-remodelling complex, RSC SWI/SNF subunit Rsc7/Swp82", "go_ids": [], "go_terms": [], "name": "CRC_Rsc7/Swp82", "pathway_ids": ["R-SCE-4551638", "R-SPO-4551638"], "pathways": ["R-SCE-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins"], "type": "Family"}, "IPR013934": {"description": "U3 small nucleolar RNA-associated protein 13, C-terminal", "go_ids": ["GO:0006364", "GO:0032040"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0032040:small-subunit processome:C"], "name": "Utp13_C", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR013935": {"description": "Trs120/TRAPPC9", "go_ids": [], "go_terms": [], "name": "Trs120_TRAPPC9", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-MMU-8876198", "R-DME-8876198", "R-SCE-204005", "R-SPO-204005", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198", "R-DME-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Family"}, "IPR013936": {"description": "Chloroquine-resistance transporter-like", "go_ids": [], "go_terms": [], "name": "CRT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013937": {"description": "Sorting nexin, C-terminal", "go_ids": [], "go_terms": [], "name": "Sorting_nexin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013938": {"description": "Phosphodiesterase 8, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PDE8_N", "pathway_ids": ["R-HSA-418555", "R-MMU-418555"], "pathways": ["R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Domain"}, "IPR013939": {"description": "Regulatory subunit Dfp1/Him1, central region", "go_ids": [], "go_terms": [], "name": "Regulatory_Dfp1/Him1", "pathway_ids": ["R-SCE-176187", "R-SPO-68962", "R-SCE-68962", "R-SPO-176187"], "pathways": ["R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR013940": {"description": "Meiosis specific protein Spo22/ZIP4/TEX11", "go_ids": ["GO:0051321"], "go_terms": ["GO:0051321:meiotic cell cycle:P"], "name": "Spo22/ZIP4/TEX11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013941": {"description": "Protein Zds1, C-terminal", "go_ids": [], "go_terms": [], "name": "ZDS1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013942": {"description": "Mediator complex, subunit Med19, fungi", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med19_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013943": {"description": "Mitochondrial protein Pet127", "go_ids": ["GO:0000959", "GO:0005739"], "go_terms": ["GO:0000959:mitochondrial RNA metabolic process:P", "GO:0005739:mitochondrion:C"], "name": "Pet127", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013944": {"description": "Oxidoreductase putative, C-terminal", "go_ids": [], "go_terms": [], "name": "OxRdtase_put_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013945": {"description": "V-type ATPase assembly factor Pkr1", "go_ids": ["GO:0070072"], "go_terms": ["GO:0070072:vacuolar proton-transporting V-type ATPase complex assembly:P"], "name": "Pkr1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013946": {"description": "NCA2-like", "go_ids": [], "go_terms": [], "name": "NCA2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013947": {"description": "Mediator complex, subunit Med14", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med14", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR013948": {"description": "DNA replication regulator Sld3, C-terminal", "go_ids": [], "go_terms": [], "name": "DNA_replication_reg_Sld3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013949": {"description": "U3 small nucleolar RNA-associated protein 6", "go_ids": ["GO:0000462", "GO:0030515"], "go_terms": ["GO:0000462:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA):P", "GO:0030515:snoRNA binding:F"], "name": "Utp6", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR013950": {"description": "Kinetochore Mis14/Nsl1", "go_ids": ["GO:0000776", "GO:0000070"], "go_terms": ["GO:0000776:kinetochore:C", "GO:0000070:mitotic sister chromatid segregation:P"], "name": "Mis14/Nsl1", "pathway_ids": ["R-MMU-2500257", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-68877", "R-MMU-2467813", "R-HSA-5663220", "R-HSA-141444", "R-MMU-68877", "R-MMU-9648025", "R-HSA-9648025", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR013951": {"description": "Histone deacetylation protein Rxt3", "go_ids": [], "go_terms": [], "name": "Rxt3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013952": {"description": "Protein of unknown function DUF1776, fungi", "go_ids": [], "go_terms": [], "name": "DUF1776_fun", "pathway_ids": ["R-SPO-5365859", "R-SPO-193144", "R-SPO-9757110", "R-SPO-194002", "R-SPO-77111", "R-SPO-77108"], "pathways": ["R-SPO-5365859:r:RA biosynthesis pathway", "R-SPO-193144:r:Estrogen biosynthesis", "R-SPO-9757110:r:Prednisone ADME", "R-SPO-194002:r:Glucocorticoid biosynthesis", "R-SPO-77111:r:Synthesis of Ketone Bodies", "R-SPO-77108:r:Utilization of Ketone Bodies"], "type": "Family"}, "IPR013953": {"description": "FACT complex subunit SPT16, middle domain", "go_ids": [], "go_terms": [], "name": "FACT_SPT16_M", "pathway_ids": ["R-CEL-75955", "R-SPO-674695", "R-MMU-6796648", "R-DME-674695", "R-HSA-167238", "R-HSA-167243", "R-DME-6796648", "R-SCE-6804756", "R-MMU-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-6804756", "R-DDI-674695", "R-CEL-112382", "R-HSA-167152", "R-SCE-674695", "R-DDI-6796648", "R-HSA-75955", "R-DDI-6804756", "R-CEL-6804756", "R-SPO-6796648", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382", "R-SCE-6796648"], "pathways": ["R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes"], "type": "Domain"}, "IPR013954": {"description": "Polynucleotide kinase 3 phosphatase", "go_ids": [], "go_terms": [], "name": "PNK3P", "pathway_ids": ["R-HSA-5649702", "R-MMU-5649702"], "pathways": ["R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "type": "Family"}, "IPR013955": {"description": "Replication factor A, C-terminal", "go_ids": [], "go_terms": [], "name": "Rep_factor-A_C", "pathway_ids": ["R-HSA-5693616", "R-GGA-174437", "R-HSA-5696397", "R-GGA-110314", "R-MMU-110320", "R-MMU-6804756", "R-GGA-351468", "R-HSA-5655862", "R-MMU-5685938", "R-MMU-110314", "R-MMU-69473", "R-MMU-5696395", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-MMU-174437", "R-GGA-6782135", "R-HSA-5656121", "R-GGA-5696400", "R-MMU-5358606", "R-MMU-5358565", "R-GGA-68962", "R-DRE-6804756", "R-DRE-6782210", "R-GGA-110320", "R-HSA-69473", "R-MMU-5651801", "R-MMU-68962", "R-DRE-5685942", "R-HSA-110312", "R-GGA-6782210", "R-HSA-6783310", "R-DRE-3371453", "R-DRE-174437", "R-GGA-110312", "R-GGA-5656169", "R-HSA-6804756", "R-GGA-5358565", "R-GGA-5651801", "R-DRE-69473", "R-HSA-5696395", "R-DRE-5358565", "R-MMU-176187", "R-MMU-6782210", "R-MMU-3108214", "R-GGA-5693607", "R-MMU-5696397", "R-GGA-176187", "R-HSA-110314", "R-HSA-3371511", "R-DRE-5358606", "R-DRE-5693607", "R-GGA-5685938", "R-DRE-176187", "R-HSA-3108214", "R-HSA-5685942", "R-GGA-3108214", "R-GGA-5685942", "R-MMU-6782135", "R-GGA-5358606", "R-HSA-5358606", "R-DRE-5656121", "R-DRE-5696400", "R-MMU-110312", "R-GGA-5655862", "R-DRE-5656169", "R-DRE-5696395", "R-DRE-69166", "R-DRE-3108214", "R-GGA-353303", "R-HSA-912446", "R-HSA-68962", "R-HSA-6782210", "R-HSA-5656169", "R-DRE-110312", "R-HSA-5685938", "R-HSA-176187", "R-MMU-5696400", "R-MMU-5693607", "R-MMU-3371453", "R-MMU-5655862", "R-GGA-6783310", "R-GGA-351451", "R-DRE-5696397", "R-GGA-5696397", "R-GGA-5656121", "R-DRE-5655862", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-HSA-69166", "R-GGA-3371453", "R-GGA-5696395", "R-MMU-6783310", "R-MMU-5656121", "R-DRE-110320", "R-DRE-6782135", "R-DRE-68962", "R-MMU-69166", "R-HSA-5696400", "R-HSA-5358565", "R-DRE-5651801", "R-DRE-110314", "R-HSA-174437", "R-GGA-69166", "R-HSA-110320", "R-DRE-5685938"], "pathways": ["R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-GGA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-6804756:r:Regulation of TP53 Activity through 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TP53 Activity through Phosphorylation", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-110312:r:Translesion synthesis by REV1", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-GGA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-3371511:r:HSF1 activation", "R-DRE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DRE-176187:r:Activation of ATR in response to replication stress", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-GGA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DRE-5656121:r:Translesion synthesis by POLI", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-MMU-110312:r:Translesion synthesis by REV1", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-DRE-5656169:r:Termination of translesion DNA synthesis", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-69166:r:Removal of the Flap Intermediate", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-912446:r:Meiotic recombination", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DRE-110312:r:Translesion synthesis by REV1", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-GGA-6783310:r:Fanconi Anemia Pathway", "R-GGA-351451:r:Homologous recombination repair of replication-dependent double-strand breaks", "R-DRE-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-DRE-5655862:r:Translesion synthesis by POLK", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-GGA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-DRE-6782135:r:Dual incision in TC-NER", "R-DRE-68962:r:Activation of the pre-replicative complex", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-69166:r:Removal of the Flap Intermediate", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR013956": {"description": "E3 ubiquitin ligase Bre1", "go_ids": ["GO:0004842"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F"], "name": "E3_ubiquit_lig_Bre1", "pathway_ids": ["PWY-7511", "R-HSA-8866654", "R-MMU-8866654", "R-MMU-9013422", "R-HSA-9013422", "R-DME-8866654", "R-BTA-8866654", "R-DME-9013422", "R-RNO-8866654", "R-DDI-9013422", "R-BTA-9013422"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-9013422:r:RHOBTB1 GTPase cycle"], "type": "Family"}, "IPR013957": {"description": "U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein", "go_ids": ["GO:0008380"], "go_terms": ["GO:0008380:RNA splicing:P"], "name": "SNRNP27", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR013958": {"description": "DASH complex subunit Dad1", "go_ids": ["GO:0042729", "GO:0072686"], "go_terms": ["GO:0042729:DASH complex:C", "GO:0072686:mitotic spindle:C"], "name": "DASH_Dad1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013959": {"description": "DASH complex subunit Dad4", "go_ids": ["GO:0008608", "GO:0042729", "GO:0072686"], "go_terms": ["GO:0008608:attachment of spindle microtubules to kinetochore:P", "GO:0042729:DASH complex:C", "GO:0072686:mitotic spindle:C"], "name": "DASH_Dad4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013960": {"description": "DASH complex subunit Duo1", "go_ids": ["GO:0000278", "GO:0072686", "GO:0042729"], "go_terms": ["GO:0000278:mitotic cell cycle:P", "GO:0072686:mitotic spindle:C", "GO:0042729:DASH complex:C"], "name": "DASH_Duo1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013961": {"description": "RAI1-like", "go_ids": [], "go_terms": [], "name": "RAI1", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-9930044"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-9930044:r:Nuclear RNA decay"], "type": "Domain"}, "IPR013962": {"description": "DASH complex subunit Dam1", "go_ids": ["GO:0008608", "GO:0072686", "GO:0042729"], "go_terms": ["GO:0008608:attachment of spindle microtubules to kinetochore:P", "GO:0072686:mitotic spindle:C", "GO:0042729:DASH complex:C"], "name": "DASH_Dam1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013963": {"description": "DASH complex subunit Dad2", "go_ids": ["GO:0000278", "GO:0042729", "GO:0072686"], "go_terms": ["GO:0000278:mitotic cell cycle:P", "GO:0042729:DASH complex:C", "GO:0072686:mitotic spindle:C"], "name": "DASH_Dad2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013964": {"description": "DASH complex subunit Ask1", "go_ids": ["GO:0008608", "GO:0042729", "GO:0072686"], "go_terms": ["GO:0008608:attachment of spindle microtubules to kinetochore:P", "GO:0042729:DASH complex:C", "GO:0072686:mitotic spindle:C"], "name": "DASH_Ask1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013965": {"description": "DASH complex subunit Dad3", "go_ids": ["GO:0008608", "GO:0072686", "GO:0042729"], "go_terms": ["GO:0008608:attachment of spindle microtubules to kinetochore:P", "GO:0072686:mitotic spindle:C", "GO:0042729:DASH complex:C"], "name": "DASH_Dad3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013966": {"description": "DASH complex subunit Spc34", "go_ids": ["GO:0008608", "GO:0005876", "GO:0042729"], "go_terms": ["GO:0008608:attachment of spindle microtubules to kinetochore:P", "GO:0005876:spindle microtubule:C", "GO:0042729:DASH complex:C"], "name": "Spc34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR013967": {"description": "Rad54, N-terminal", "go_ids": ["GO:0016817"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F"], "name": "Rad54_N", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR013968": {"description": "Polyketide synthase-like, ketoreductase domain", "go_ids": [], "go_terms": [], "name": "PKS_KR", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-DDI-75105", "R-HSA-75105", "R-DDI-199220", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR013969": {"description": "Oligosaccharide biosynthesis protein Alg14-like", "go_ids": ["GO:0006488"], "go_terms": ["GO:0006488:dolichol-linked oligosaccharide biosynthetic process:P"], "name": "Oligosacch_biosynth_Alg14", "pathway_ids": ["R-HSA-5633231", "R-MMU-446193", "R-SPO-446193", "R-RNO-446193", "R-HSA-446193"], "pathways": ["R-HSA-5633231:r:Defective ALG14 causes ALG14-CMS", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-RNO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Family"}, "IPR013970": {"description": "Replication factor A protein 3", "go_ids": ["GO:0006260", "GO:0006281", "GO:0003677", "GO:0005634", "GO:0006310"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0006281:DNA repair:P", "GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006310:DNA recombination:P"], "name": "Rfa2", "pathway_ids": ["R-HSA-3371511", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-5693616", "R-SPO-5656121", "R-SPO-5655862", "R-HSA-5696397", "R-HSA-5358606", "R-SPO-5656169", "R-MMU-110320", "R-MMU-6804756", "R-MMU-110312", "R-SPO-110312", "R-MMU-5685938", "R-HSA-5655862", "R-MMU-110314", "R-MMU-69473", "R-SPO-5696395", "R-MMU-5696395", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-HSA-912446", "R-MMU-174437", "R-HSA-68962", "R-HSA-6782210", "R-HSA-5656121", "R-HSA-5656169", "R-MMU-5358606", "R-HSA-5685938", "R-HSA-176187", "R-SPO-69166", "R-MMU-5696400", "R-MMU-5693607", "R-MMU-5358565", "R-MMU-3371453", "R-MMU-5655862", "R-SPO-176187", "R-SPO-5696397", "R-HSA-69473", "R-MMU-5651801", "R-MMU-68962", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-110312", "R-HSA-69166", "R-HSA-5651801", "R-HSA-6783310", "R-MMU-6783310", "R-MMU-5656121", "R-HSA-6804756", "R-SPO-5696400", "R-SPO-110320", "R-SPO-6782210", "R-HSA-5696395", "R-SPO-110314", "R-MMU-69166", "R-MMU-176187", "R-HSA-5696400", "R-HSA-5358565", "R-SPO-68962", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-HSA-174437", "R-HSA-110320", "R-HSA-110314", "R-SPO-5651801"], "pathways": ["R-HSA-3371511:r:HSF1 activation", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-912446:r:Meiotic recombination", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-110312:r:Translesion synthesis by REV1", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR013971": {"description": "HalX domain", "go_ids": [], "go_terms": [], "name": "HalX_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013972": {"description": "YcbB domain", "go_ids": [], "go_terms": [], "name": "YcbB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013974": {"description": "SAF domain", "go_ids": [], "go_terms": [], "name": "SAF", "pathway_ids": ["R-MMU-4085001", "R-HSA-4085001", "R-DME-4085001"], "pathways": ["R-MMU-4085001:r:Sialic acid metabolism", "R-HSA-4085001:r:Sialic acid metabolism", "R-DME-4085001:r:Sialic acid metabolism"], "type": "Domain"}, "IPR013975": {"description": "Transcription regulator BetR, N-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_BetR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013976": {"description": "Cyclic di-GMP phosphodiesterase CdgJ, HDOD domain", "go_ids": [], "go_terms": [], "name": "HDOD_CdgJ-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013977": {"description": "Aminomethyltransferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GcvT_C", "pathway_ids": ["R-MMU-204174", "R-HSA-6798163", "R-HSA-204174", "R-MMU-6783984", "R-RNO-6798163", "R-BTA-6783984", "R-SCE-6783984", "R-HSA-6783984", "R-DDI-6783984", "R-MMU-6798163", "R-SPO-6783984", "R-CFA-6783984"], "pathways": ["R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-6798163:r:Choline catabolism", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-6783984:r:Glycine degradation", "R-RNO-6798163:r:Choline catabolism", "R-BTA-6783984:r:Glycine degradation", "R-SCE-6783984:r:Glycine degradation", "R-HSA-6783984:r:Glycine degradation", "R-DDI-6783984:r:Glycine degradation", "R-MMU-6798163:r:Choline catabolism", "R-SPO-6783984:r:Glycine degradation", "R-CFA-6783984:r:Glycine degradation"], "type": "Domain"}, "IPR013978": {"description": "MEKHLA", "go_ids": [], "go_terms": [], "name": "MEKHLA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013979": {"description": "Translation initiation factor, beta propellor-like domain", "go_ids": [], "go_terms": [], "name": "TIF_beta_prop-like", "pathway_ids": ["R-CEL-72689", "R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-72695", "R-BTA-72689", "R-RNO-72695", "R-MMU-72706", "R-SPO-72689", "R-BTA-72695", "R-SCE-72695", "R-SCE-72702", "R-MMU-72695", "R-SCE-156827", "R-BTA-156827", "R-DME-72695", "R-MMU-72702", "R-RNO-156827", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-BTA-72702", "R-DME-72689", "R-HSA-72706", "R-RNO-72702", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-CEL-156827", "R-RNO-72649", "R-SCE-72649", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-BTA-72649", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": ["R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Domain"}, "IPR013980": {"description": "MANSC domain", "go_ids": [], "go_terms": [], "name": "MANSC_dom", "pathway_ids": ["R-MMU-8856828", "R-HSA-8852405", "R-MMU-8852405", "R-RNO-8856825", "R-MMU-6806942", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-RNO-8856828", "R-HSA-6806942"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8852405:r:Signaling by MST1", "R-MMU-8852405:r:Signaling by MST1", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-6806942:r:MET Receptor Activation"], "type": "Domain"}, "IPR013983": {"description": "Aldehyde ferredoxin oxidoreductase, N-terminal", "go_ids": ["GO:0016625", "GO:0051536", "GO:0016491"], "go_terms": ["GO:0016625:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor:F", "GO:0051536:iron-sulfur cluster binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "Ald_Fedxn_OxRdtase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013984": {"description": "Aldehyde ferredoxin oxidoreductase, domain 2", "go_ids": [], "go_terms": [], "name": "Ald_Fedxn_OxRdtase_dom2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR013985": {"description": "Aldehyde ferredoxin oxidoreductase, domain 3", "go_ids": ["GO:0016625", "GO:0051536"], "go_terms": ["GO:0016625:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Ald_Fedxn_OxRdtase_dom3", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR013986": {"description": "DExx box DNA helicase domain superfamily", "go_ids": [], "go_terms": [], "name": "DExx_box_DNA_helicase_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR013987": {"description": "Protein YjdM, N-terminal", "go_ids": [], "go_terms": [], "name": "YjdM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013988": {"description": "Protein YjdM, C-terminal", "go_ids": [], "go_terms": [], "name": "YjdM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013989": {"description": "Development/cell death domain", "go_ids": [], "go_terms": [], "name": "Dev_and_cell_death_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013990": {"description": "Water stress and hypersensitive response domain", "go_ids": ["GO:0009269"], "go_terms": ["GO:0009269:response to desiccation:P"], "name": "WHy-dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013991": {"description": "PhnA protein N-terminal, proteobacterial", "go_ids": [], "go_terms": [], "name": "PhnaA_N_proteobac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR013992": {"description": "Adenylate cyclase-associated CAP, N-terminal", "go_ids": ["GO:0003779", "GO:0007010"], "go_terms": ["GO:0003779:actin binding:F", "GO:0007010:cytoskeleton organization:P"], "name": "Adenylate_cyclase-assoc_CAP_N", "pathway_ids": ["R-DDI-6798695", "R-HSA-114608", "R-SPO-6798695", "R-HSA-6798695", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-428890", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Conserved_site"}, "IPR014000": {"description": "DNA helicase E1, N-terminal, Papillomavirus", "go_ids": ["GO:0016817"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F"], "name": "PPV_DNA_helicase_E1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014001": {"description": "Helicase superfamily 1/2, ATP-binding domain", "go_ids": [], "go_terms": [], "name": "Helicase_ATP-bd", "pathway_ids": ["R-BTA-975957", "R-CEL-72165", "R-MMU-9770562", "R-HSA-9010553", "R-CFA-72163", "R-DDI-73776", "R-MMU-6804756", "R-DDI-6782210", "R-SPO-9930044", "R-DDI-72163", "R-MMU-5685938", "R-DME-5696394", "R-MMU-69473", "R-MMU-5689880", "R-CEL-9770562", "R-MMU-5696394", "R-SPO-6796648", "R-MMU-8866654", "R-DDI-6798695", "R-HSA-3270619", "R-DRE-3769402", "R-MMU-9934037", "R-HSA-9694686", "R-HSA-3247509", "R-MMU-3134975", "R-HSA-9670615", "R-HSA-72163", "R-RNO-9764725", "R-BTA-1810476", "R-HSA-9670095", "R-DDI-113418", "R-SPO-73779", "R-MMU-72086", "R-MMU-3108214", "R-CEL-9031628", "R-BTA-9648025", "R-DME-3134963", "R-HSA-426486", "R-DME-9933946", "R-DRE-5696400", "R-DME-72649", "R-BTA-9764725", "R-CEL-9934037", "R-RNO-3134963", "R-MMU-5693565", "R-DME-9770562", "R-DDI-73772", "R-MMU-429947", "R-HSA-912446", "R-DDI-76042", "R-CEL-72163", "R-MMU-5696400", "R-RNO-9933946", "R-SCE-73779", "R-HSA-2564830", "R-HSA-8983711", "R-MMU-3899300", "R-DME-6798695", "R-RNO-75955", "R-HSA-381340", "R-SCE-430039", "R-SCE-6781823", "R-DME-5696395", "R-HSA-9709603", "R-MMU-3214858", "R-BTA-9934037", "R-MMU-6783310", "R-MMU-426486", "R-MMU-77075", "R-SPO-6782210", "R-HSA-3214847", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-CEL-159236", "R-HSA-6798695", "R-DME-9933947", "R-HSA-2151201", "R-HSA-5693616", "R-CFA-72187", "R-MMU-2467813", "R-CEL-6798695", "R-DME-6791226", "R-HSA-6781823", "R-SPO-5696395", "R-MMU-9954716", "R-MMU-430039", "R-HSA-75953", "R-CEL-4551638", "R-MMU-174437", "R-HSA-77075", "R-SPO-72086", "R-HSA-1266695", "R-CFA-73856", "R-HSA-606279", "R-MMU-5250924", "R-RNO-156827", "R-DDI-73779", "R-SPO-72706", "R-DME-674695", "R-BTA-72086", "R-RNO-73762", "R-SCE-76042", "R-HSA-167200", "R-RNO-112382", "R-CEL-9930044", "R-HSA-159236", "R-BTA-72649", "R-DME-8943724", "R-MMU-400206", "R-HSA-9818027", "R-CEL-9933947", "R-DDI-6782135", "R-SPO-6798695", "R-DME-8939243", "R-CEL-72702", "R-XTR-72163", "R-BTA-5663220", "R-SSC-159236", "R-MMU-72649", "R-XTR-429947", "R-DRE-5696395", "R-HSA-918233", "R-HSA-9636383", "R-GGA-353303", "R-HSA-113418", "R-DME-5689603", "R-DDI-430039", "R-BTA-73762", "R-MMU-2500257", "R-MMU-72702", "R-SCE-72086", "R-BTA-9933947", "R-HSA-73762", "R-MMU-1169408", "R-SCE-72649", "R-CEL-3214858", "R-HSA-9692916", "R-HSA-5250924", "R-HSA-174437", "R-CEL-9933939", "R-CEL-8939243", "R-MMU-9909505", "R-MMU-9933946", "R-HSA-9013418", "R-MMU-1266695", "R-HSA-9833482", "R-RNO-73779", "R-MMU-3214815", "R-MMU-606279", "R-SPO-6781823", "R-HSA-5693565", "R-BTA-3247509", "R-MMU-3134963", "R-HSA-167158", "R-MMU-75955", "R-SPO-975957", "R-SCE-429958", "R-HSA-73776", "R-BTA-77075", "R-DME-9764725", "R-DME-73856", "R-DME-6782135", "R-SCE-72702", "R-BTA-72163", "R-MMU-6791226", "R-DRE-6782210", "R-BTA-75953", "R-BTA-6791226", "R-HSA-69473", "R-CEL-72662", "R-RNO-9933947", "R-DME-1834941", "R-HSA-6783310", "R-RNO-72649", "R-HSA-167161", "R-XTR-426486", "R-HSA-9933937", "R-HSA-5696395", "R-DDI-77075", "R-BTA-8939243", "R-HSA-167160", "R-DME-3247509", "R-CEL-72649", "R-DME-72702", "R-HSA-9031628", "R-BTA-9833482", "R-MMU-5663220", "R-HSA-9954716", "R-HSA-9705671", "R-HSA-5685942", "R-DME-429947", "R-HSA-933542", "R-SSC-72187", "R-DME-77075", "R-DME-3214815", "R-BTA-1266695", "R-MMU-6781823", "R-BTA-6781823", "R-DRE-73856", "R-DME-3214858", "R-GGA-72163", "R-HSA-68877", "R-HSA-9843970", "R-HSA-2559584", "R-HSA-72165", "R-MMU-73776", "R-SPO-429958", "R-HSA-167172", "R-HSA-5693568", "R-DRE-6781823", "R-MMU-191859", "R-MMU-5693607", "R-BTA-73779", "R-MMU-8983711", "R-DME-113418", "R-BTA-9954716", "R-DRE-73772", "R-MMU-975957", "R-SCE-9018519", "R-HSA-201722", "R-HSA-73863", "R-HSA-975957", "R-SPO-73772", "R-DRE-6782135", "R-DME-5696400", "R-MMU-72165", "R-RNO-5696400", "R-HSA-5663220", "R-RNO-3769402", "R-HSA-2426168", "R-MMU-9707564", "R-HSA-1989781", "R-SCE-75953", "R-MMU-113418", "R-RNO-3214858", "R-BTA-76042", "R-SSC-9013418", "R-RNO-73863", "R-MMU-5693616", "R-HSA-1368108", "R-HSA-9709570", "R-DRE-6796648", "R-RNO-9954716", "R-BTA-429947", "R-DME-1266695", "R-HSA-9707564", "R-MMU-3247509", "R-DME-6804758", "R-BTA-9013418", "R-HSA-429958", "R-HSA-9018519", "R-HSA-6784531", "R-MMU-73856", "R-HSA-3214815", "R-RNO-9933937", "R-RNO-429947", "R-MMU-203927", "R-DME-72165", "R-HSA-6791226", "R-HSA-9704331", "R-MMU-6782210", "R-HSA-5693554", "R-HSA-5689603", "R-XTR-430039", "R-MMU-73762", "R-HSA-3769402", "R-MMU-6782135", "R-MMU-9933937", "R-MMU-429958", "R-DME-159236", "R-DME-6796648", "R-HSA-936440", "R-HSA-1169408", "R-HSA-3214858", "R-HSA-9909505", "R-HSA-167162", "R-XTR-975957", "R-DRE-159236", "R-BTA-2467813", "R-CEL-8943724", "R-HSA-9845323", "R-DME-9933937", "R-HSA-9920951", "R-BTA-5696395", "R-SCE-6782210", "R-HSA-9918481", "R-BTA-6796648", "R-DDI-1169408", "R-DRE-76042", "R-SPO-72649", "R-MMU-73863", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-9679191", "R-DME-9013418", "R-HSA-1810476", "R-DRE-674695", "R-BTA-159236", "R-DDI-75953", "R-DME-73772", "R-BTA-141444", "R-SPO-6791226", "R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-GGA-73856", "R-DME-72163", "R-RNO-72163", "R-BTA-201722", "R-HSA-9918487", "R-DRE-2467813", "R-BTA-9933946", "R-MMU-68877", "R-MMU-2559584", "R-RNO-73776", "R-DRE-75955", "R-HSA-3134963", "R-DME-72086", "R-SCE-6791226", "R-HSA-9844594", "R-MMU-1810476", "R-BTA-2500257", "R-GGA-159236", "R-DME-75953", "R-MMU-9930044", "R-BTA-75955", "R-SPO-159236", "R-SPO-9018519", "R-RNO-5696395", "R-BTA-72702", "R-HSA-72706", "R-GGA-9954716", "R-HSA-8866654", "R-MMU-9933939", "R-DME-112382", "R-HSA-6804756", "R-HSA-9918476", "R-BTA-6782210", "R-MMU-9696264", "R-MMU-9013418", "R-SPO-73776", "R-RNO-72662", "R-HSA-72662", "R-SCE-429947", "R-HSA-9833109", "R-DDI-5696395", "R-HSA-191859", "R-HSA-156827", "R-DME-9934037", "R-HSA-9934037", "R-DRE-72163", "R-DME-73776", "R-MMU-72662", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-RNO-159236", "R-MMU-5685939", "R-MMU-5693579", "R-HSA-9701192", "R-RNO-9013418", "R-SCE-156827", "R-SPO-72662", "R-MMU-6796648", "R-HSA-9839394", "R-HSA-9770562", "R-RNO-6796648", "R-SSC-72163", "R-HSA-9707616", "R-BTA-674695", "R-HSA-5685939", "R-DME-9833482", "R-HSA-933541", "R-HSA-75955", "R-DME-430039", "R-HSA-933543", "R-HSA-427389", "R-DDI-975957", "R-RNO-3247509", "R-SCE-73772", "R-DME-975957", "R-CFA-9013418", "R-XTR-203927", "R-HSA-9920588", "R-RNO-674695", "R-HSA-5689896", "R-DME-76042", "R-DDI-1834941", "R-DRE-73779", "R-DRE-75953", "R-DRE-141444", "R-HSA-6796648", "R-MMU-72706", "R-HSA-167246", "R-MMU-5696395", "R-HSA-5693607", "R-DRE-113418", "R-RNO-72165", "R-HSA-9933387", "R-HSA-8943724", "R-SSC-73856", "R-RNO-6782210", "R-SPO-113418", "R-BTA-156827", "R-DME-72662", "R-MMU-141444", "R-MMU-2559586", "R-HSA-9918432", "R-HSA-9933947", "R-DDI-6781823", "R-SCE-72662", "R-BTA-73856", "R-MMU-1834941", "R-MMU-159236", "R-RNO-6791226", "R-SPO-9770562", "R-HSA-8939243", "R-HSA-400206", "R-BTA-9770562", "R-MMU-6798695", "R-BTA-1169408", "R-RNO-75953", "R-SCE-6782135", "R-SPO-72702", "R-HSA-9930044", "R-HSA-3108214", "R-BTA-113418", "R-HSA-9704646", "R-BTA-9933937", "R-DRE-77075", "R-HSA-6804758", "R-DRE-73863", "R-HSA-112126", "R-BTA-9933939", "R-CEL-9933946", "R-RNO-9933939", "R-HSA-5685938", "R-HSA-1222387", "R-HSA-9931509", "R-CEL-426486", "R-RNO-72086", "R-RNO-1266695", "R-HSA-2500257", "R-DRE-2500257", "R-DRE-72086", "R-HSA-9754678", "R-HSA-9824585", "R-CEL-1169408", "R-CEL-9764725", "R-SCE-77075", "R-HSA-9843940", "R-SPO-6782135", "R-HSA-3899300", "R-HSA-9933946", "R-RNO-6781823", "R-HSA-174414", "R-HSA-5689880", "R-HSA-427413", "R-HSA-9918485", "R-HSA-73856", "R-XTR-159236", "R-DME-75955", "R-MMU-112382", "R-DME-9933939", "R-RNO-73856", "R-SPO-76042", "R-MMU-174414", "R-DDI-674695", "R-DRE-5663220", "R-HSA-9824594", "R-SPO-3899300", "R-BTA-73863", "R-MMU-72163", "R-CEL-9933937", "R-HSA-429947", "R-BTA-6782135", "R-HSA-141444", "R-RNO-9934037", "R-HSA-9764725", "R-DRE-171319", "R-HSA-72702", "R-MMU-9031628", "R-HSA-9696264", "R-MMU-6804758", "R-RNO-9696264", "R-HSA-9820841", "R-HSA-9670613", "R-MMU-73772", "R-HSA-5696394", "R-DDI-3899300", "R-BTA-73772", "R-BTA-73776", "R-SCE-73776", "R-HSA-6781827", "R-HSA-2467813", "R-HSA-168928", "R-HSA-8854214", "R-DDI-6791226", "R-SCE-6798695", "R-HSA-9682706", "R-DME-73779", "R-DRE-191859", "R-HSA-6790901", "R-HSA-9820865", "R-DRE-9770562", "R-HSA-203927", "R-DME-9031628", "R-BTA-3134963", "R-BTA-5696400", "R-DME-3108214", "R-RNO-113418", "R-HSA-9760173", "R-RNO-72702", "R-DRE-73776", "R-HSA-72649", "R-MMU-156827", "R-MMU-8943724", "R-RNO-77075", "R-MMU-72187", "R-RNO-9770562", "R-HSA-5696400", "R-HSA-5693579", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-CEL-3134963", "R-DME-6781823", "R-HSA-1834941", "R-MMU-201722", "R-HSA-72187", "R-RNO-8939243", "R-MMU-9833482", "R-CEL-203927", "R-SCE-3899300", "R-MMU-5693568", "R-CEL-6791226", "R-HSA-5621480", "R-MMU-73779", "R-HSA-4551638", "R-MMU-76042", "R-SPO-75953", "R-HSA-5601884", "R-HSA-430039", "R-RNO-975957", "R-RNO-76042", "R-CEL-9833482", "R-DDI-72086", "R-HSA-9648025", "R-MMU-674695", "R-CEL-156827", "R-MMU-9018519", "R-SCE-674695", "R-HSA-3134975", "R-SPO-156827", "R-HSA-2559586", "R-SPO-429947", "R-DME-156827", "R-RNO-201722", "R-DME-1810476", "R-HSA-9619665", "R-HSA-72086", "R-CEL-73856", "R-DDI-9770562", "R-MMU-9670095", "R-BTA-3214858", "R-SCE-975957", "R-HSA-167152", "R-HSA-9833110", "R-MMU-5689603", "R-MMU-9648025", "R-CEL-430039", "R-SCE-6796648", "R-GGA-429947", "R-MMU-3769402", "R-SPO-77075", "R-RNO-73772", "R-HSA-390471", "R-SCE-113418", "R-RNO-6782135", "R-HSA-9933939", "R-RNO-5250924", "R-DRE-975957", "R-HSA-9708296", "R-MMU-9764725", "R-MMU-8939243", "R-GGA-975957", "R-MMU-9933947", "R-SPO-5696400", "R-MMU-936440", "R-DDI-9954716"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-9930044:r:Nuclear RNA decay", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-3247509:r:Chromatin modifying enzymes", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9670615:r:Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72086:r:mRNA Capping", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-9031628:r:NGF-stimulated transcription", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-DME-72649:r:Translation initiation complex formation", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-9770562:r:mRNA Polyadenylation", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-912446:r:Meiotic recombination", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-MMU-5696400:r:Dual Incision 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UDP-glucuronate", "R-DME-173599:r:Formation of the active cofactor, UDP-glucuronate"], "type": "Domain"}, "IPR014030": {"description": "Beta-ketoacyl synthase-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "KAS_N", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-MMU-9837999", "R-DDI-75105", "R-SPO-9837999", "R-HSA-75105", "R-SCE-9837999", "R-DDI-199220", "R-HSA-9918487", "R-HSA-9837999", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR014031": {"description": "Beta-ketoacyl synthase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "KAS_C", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-MMU-9837999", "R-DDI-75105", "R-SPO-9837999", "R-HSA-75105", "R-SCE-9837999", "R-DDI-199220", "R-HSA-9918487", "R-HSA-9837999", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR014033": {"description": "Arginase", "go_ids": ["GO:0004053", "GO:0006525", "GO:0046872"], "go_terms": ["GO:0004053:arginase activity:F", "GO:0006525:arginine metabolic process:P", "GO:0046872:metal ion binding:F"], "name": "Arginase", "pathway_ids": ["PWY-6922", "PWY-31", "PWY-4984", "PWY-46", "R-HSA-6798695", "R-SPO-6798695", "R-SSC-6798695", "R-MMU-9837999", "R-SPO-70635", "R-HSA-9956514", "R-SCE-6798695", "R-HSA-70635", "R-BTA-6798695", "R-RNO-9837999", "R-RNO-70635", "R-MMU-70635", "R-SPO-9837999", "R-SCE-9837999", "R-BTA-70635", "R-MMU-6798695", "R-HSA-9837999", "R-SSC-70635", "R-SCE-70635", "R-RNO-6798695"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-31:t:L-canavanine degradation I", "PWY-4984:t:urea cycle", "PWY-46:t:putrescine biosynthesis III", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-70635:r:Urea cycle", "R-HSA-9956514:r:ARG1 variants cause hyperargininemia", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-70635:r:Urea cycle", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-70635:r:Urea cycle", "R-MMU-70635:r:Urea cycle", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-70635:r:Urea cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-70635:r:Urea cycle", "R-SCE-70635:r:Urea cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR014036": {"description": "DeoR-like transcriptional repressor, C-terminal sensor domain", "go_ids": [], "go_terms": [], "name": "DeoR-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014038": {"description": "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain", "go_ids": ["GO:0003746", "GO:0006414"], "go_terms": ["GO:0003746:translation elongation factor activity:F", "GO:0006414:translational elongation:P"], "name": "EF1B_bsu/dsu_GNE", "pathway_ids": ["R-MMU-156842", "R-SSC-156842", "R-BTA-156842", "R-RNO-156842", "R-HSA-156842", "R-XTR-156842", "R-SCE-156842", "R-DME-156842", "R-DDI-156842", "R-SPO-156842"], "pathways": ["R-MMU-156842:r:Eukaryotic Translation Elongation", "R-SSC-156842:r:Eukaryotic Translation Elongation", "R-BTA-156842:r:Eukaryotic Translation Elongation", "R-RNO-156842:r:Eukaryotic Translation Elongation", "R-HSA-156842:r:Eukaryotic Translation Elongation", "R-XTR-156842:r:Eukaryotic Translation Elongation", "R-SCE-156842:r:Eukaryotic Translation Elongation", "R-DME-156842:r:Eukaryotic Translation Elongation", "R-DDI-156842:r:Eukaryotic Translation Elongation", "R-SPO-156842:r:Eukaryotic Translation Elongation"], "type": "Domain"}, "IPR014039": {"description": "Translation elongation factor EFTs/EF1B, dimerisation", "go_ids": ["GO:0003746", "GO:0006414"], "go_terms": ["GO:0003746:translation elongation factor activity:F", "GO:0006414:translational elongation:P"], "name": "Transl_elong_EFTs/EF1B_dimer", "pathway_ids": ["R-HSA-5389840"], "pathways": ["R-HSA-5389840:r:Mitochondrial translation elongation"], "type": "Domain"}, "IPR014041": {"description": "ESCRT-II complex, Vps25 subunit, N-terminal winged helix", "go_ids": [], "go_terms": [], "name": "ESCRT-II_cplx_Vps25-sub_N", "pathway_ids": ["R-RNO-917729", "R-HSA-917729", "R-HSA-9610379", "R-DRE-917729", "R-MMU-917729", "R-SPO-917729", "R-DDI-917729", "R-BTA-917729", "R-SCE-917729", "R-DME-917729"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SPO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Homologous_superfamily"}, "IPR014042": {"description": "Glutathione synthase, alpha-helical", "go_ids": ["GO:0006750", "GO:0004363", "GO:0005524", "GO:0016874"], "go_terms": ["GO:0006750:glutathione biosynthetic process:P", "GO:0004363:glutathione synthase activity:F", "GO:0005524:ATP binding:F", "GO:0016874:ligase activity:F"], "name": "Glutathione_synthase_a-hlx", "pathway_ids": ["PWY-8043", "R-RNO-174403", "R-HSA-174403", "R-HSA-5579006", "R-DDI-174403", "R-MMU-174403", "R-SCE-174403", "R-SPO-174403"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-HSA-5579006:r:Defective GSS causes GSS deficiency", "R-DDI-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling"], "type": "Homologous_superfamily"}, "IPR014043": {"description": "Acyl transferase domain", "go_ids": [], "go_terms": [], "name": "Acyl_transferase_dom", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-DDI-75105", "R-HSA-75105", "R-MMU-77289", "R-DME-77289", "R-DDI-199220", "R-HSA-9918487", "R-SPO-77289", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-77289", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR014044": {"description": "CAP domain", "go_ids": [], "go_terms": [], "name": "CAP_dom", "pathway_ids": ["R-HSA-1989781", "R-HSA-6798695", "R-DDI-6798695", "R-DDI-5683826", "R-CEL-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-DDI-2132295"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-5683826:r:Surfactant metabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-2132295:r:MHC class II antigen presentation"], "type": "Domain"}, "IPR014046": {"description": "Diadenylate cyclase", "go_ids": ["GO:0004016", "GO:0006171"], "go_terms": ["GO:0004016:adenylate cyclase activity:F", "GO:0006171:cAMP biosynthetic process:P"], "name": "C-di-AMP_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014047": {"description": "Chromate transporter, long chain", "go_ids": [], "go_terms": [], "name": "Chr_Tranpt_l_chain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014048": {"description": "Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding", "go_ids": ["GO:0003824", "GO:0006281"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0006281:DNA repair:P"], "name": "MethylDNA_cys_MeTrfase_DNA-bd", "pathway_ids": ["R-HSA-5657655"], "pathways": ["R-HSA-5657655:r:MGMT-mediated DNA damage reversal"], "type": "Domain"}, "IPR014049": {"description": "Glutathione synthase, N-terminal, eukaryotic", "go_ids": ["GO:0004363", "GO:0005524"], "go_terms": ["GO:0004363:glutathione synthase activity:F", "GO:0005524:ATP binding:F"], "name": "Glutathione_synthase_N_euk", "pathway_ids": ["PWY-8043", "R-RNO-174403", "R-HSA-174403", "R-HSA-5579006", "R-DDI-174403", "R-MMU-174403", "R-SCE-174403", "R-SPO-174403"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-HSA-5579006:r:Defective GSS causes GSS deficiency", "R-DDI-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling"], "type": "Homologous_superfamily"}, "IPR014051": {"description": "Phosphoesterase, HXTX", "go_ids": [], "go_terms": [], "name": "Phosphoesterase_HXTX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014052": {"description": "DNA primase, small subunit, eukaryotic/archaeal", "go_ids": ["GO:0006269", "GO:0003899"], "go_terms": ["GO:0006269:DNA replication, synthesis of primer:P", "GO:0003899:DNA-directed RNA polymerase activity:F"], "name": "DNA_primase_ssu_euk/arc", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-MMU-174430", "R-CEL-69091", "R-CEL-68962", "R-PFA-69183", "R-SCE-69091", "R-CEL-113501", "R-CEL-69166", "R-DME-113501", "R-DME-68962", "R-CEL-69183", "R-SPO-69091", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-PFA-69166", "R-SCE-68952", "R-SPO-69166", "R-HSA-113501", "R-PFA-68952", "R-SCE-69183", "R-HSA-68952", "R-MMU-68962", "R-PFA-113501", "R-HSA-174430", "R-SPO-69183", "R-MMU-113501", "R-DME-69091", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-SCE-113501", "R-SCE-68962", "R-PFA-69091", "R-HSA-9710421", "R-MMU-68952", "R-SPO-113501", "R-SPO-68952", "R-CEL-68952", "R-SCE-69166", "R-MMU-69166", "R-HSA-69183", "R-SPO-68962", "R-HSA-69091", "R-PFA-68962", "R-MMU-174411", "R-MMU-69091", "R-DME-69166"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-CEL-69091:r:Polymerase switching", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-PFA-69183:r:Processive synthesis on the lagging strand", "R-SCE-69091:r:Polymerase switching", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-68962:r:Activation of the pre-replicative complex", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-SPO-69091:r:Polymerase switching", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-PFA-69166:r:Removal of the Flap Intermediate", "R-SCE-68952:r:DNA replication initiation", 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"R-PFA-69091:r:Polymerase switching", "R-HSA-9710421:r:Defective pyroptosis", "R-MMU-68952:r:DNA replication initiation", "R-SPO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-68952:r:DNA replication initiation", "R-CEL-68952:r:DNA replication initiation", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-69091:r:Polymerase switching", "R-PFA-68962:r:Activation of the pre-replicative complex", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Family"}, "IPR014053": {"description": "Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr", "go_ids": ["GO:0006730", "GO:0030270"], "go_terms": ["GO:0006730:one-carbon metabolic process:P", 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"IPR014057": {"description": "Uncharacterized protein HI1420", "go_ids": [], "go_terms": [], "name": "HI1420", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014058": {"description": "Pteridine reductase", "go_ids": [], "go_terms": [], "name": "Pteridine_reductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014059": {"description": "TraI/TrwC, conjugative relaxase domain", "go_ids": [], "go_terms": [], "name": "TraI/TrwC_relax", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014060": {"description": "Alkaline phosphatase-like protein PglZ", "go_ids": [], "go_terms": [], "name": "PglZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014061": {"description": "Lon-like protease BrxL-like", "go_ids": [], "go_terms": [], "name": "BrxL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014062": {"description": "Arsenate reductase, glutathione/glutaredoxin type", "go_ids": ["GO:0008794"], "go_terms": ["GO:0008794:arsenate 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"Family"}, "IPR014077": {"description": "Carboxysome shell vertex protein CsoS4B", "go_ids": ["GO:0031469"], "go_terms": ["GO:0031469:bacterial microcompartment:C"], "name": "CsoS4B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014078": {"description": "Nucleoside triphosphatase YtkD", "go_ids": [], "go_terms": [], "name": "Nudix_YtkD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014079": {"description": "Phosphate butyryltransferase", "go_ids": ["GO:0019605", "GO:0016740", "GO:0050182"], "go_terms": ["GO:0019605:butyrate metabolic process:P", "GO:0016740:transferase activity:F", "GO:0050182:phosphate butyryltransferase activity:F"], "name": "Phosphate_butyryltransferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014080": {"description": "L-lactate oxidase", "go_ids": [], "go_terms": [], "name": "L_lactate_ox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014081": {"description": "Branched-chain phosphotransacylase", "go_ids": 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"IPR014086": {"description": "Cyanuric acid hydrolase/Barbiturase", "go_ids": ["GO:0016812"], "go_terms": ["GO:0016812:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides:F"], "name": "AtzD/Barbiturase", "pathway_ids": ["PWY-8025", "PWY-5169"], "pathways": ["PWY-8025:t:cyanuric acid degradation I", "PWY-5169:t:cyanuric acid degradation II"], "type": "Family"}, "IPR014087": {"description": "1-carboxybiuret hydrolase, AtzE subunit", "go_ids": [], "go_terms": [], "name": "Carboxybiuret_hydro_AtzE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014088": {"description": "Bacteriochlorophyllide d C-20 methyltransferase", "go_ids": [], "go_terms": [], "name": "BchU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014089": {"description": "Acetate-CoA ligase [ADP-forming], alpha domain", "go_ids": [], "go_terms": [], "name": "AcCoA-synth-alpha", "pathway_ids": ["PWY-5483", "PWY-5535", "PWY-8305"], "pathways": ["PWY-5483:t:pyruvate 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["GO:0016117", "GO:0016166"], "go_terms": ["GO:0016117:carotenoid biosynthetic process:P", "GO:0016166:phytoene dehydrogenase activity:F"], "name": "Phytoene_desaturase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014103": {"description": "Zeta-carotene desaturase", "go_ids": ["GO:0016117", "GO:0016719"], "go_terms": ["GO:0016117:carotenoid biosynthetic process:P", "GO:0016719:9,9'-di-cis-zeta-carotene desaturase activity:F"], "name": "Zeta_caro_desat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014104": {"description": "Myxoxanthophyll biosynthesis, C-3',4' desaturase CrtD", "go_ids": [], "go_terms": [], "name": "Myxoxanthophyll_desat_CrtD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014105": {"description": "Carotenoid/retinoid oxidoreductase", "go_ids": ["GO:0016117"], "go_terms": ["GO:0016117:carotenoid biosynthetic process:P"], "name": "Carotenoid/retinoid_OxRdtase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014106": {"description": "Phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio-type", "go_ids": ["GO:0004639", "GO:0006164"], "go_terms": ["GO:0004639:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity:F", "GO:0006164:purine nucleotide biosynthetic process:P"], "name": "SAICAR_synthase_Vibrio-typ", "pathway_ids": ["PWY-6123", "PWY-7234", "PWY-6124"], "pathways": ["PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-7234:t:inosine-5'-phosphate biosynthesis III", "PWY-6124:t:inosine-5'-phosphate biosynthesis II"], "type": "Family"}, "IPR014107": {"description": "Cytochrome c oxidase cbb3-type, CcoQ", "go_ids": [], "go_terms": [], "name": "Cyt_c_oxidase_cbb3_CcoQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014108": {"description": "Cytochrome c oxidase caa3 type assembly factor CtaG", "go_ids": [], "go_terms": [], "name": "Caa3-assmbl_CtaG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014109": {"description": "Type-F conjugative transfer system pilin assembly thiol-disulphide isomerase TrbB", "go_ids": [], "go_terms": [], "name": "Thiol-disulphide_isomerase_rbB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014110": {"description": "Type-F conjugative transfer system pilin assembly protein TraF", "go_ids": [], "go_terms": [], "name": "TraF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014111": {"description": "Type IV conjugative transfer system protein TraF-like", "go_ids": [], "go_terms": [], "name": "T4SS_TraF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014112": {"description": "Type-F conjugative transfer system pilin chaperone TraQ, proteobacteria", "go_ids": [], "go_terms": [], "name": "TraQ_proteobacteria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014113": {"description": "Type-F conjugative transfer system pilin assembly protein TrbC, subgroup", "go_ids": [], "go_terms": [], "name": "T4SS_TrbC_subgr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014114": {"description": "Type-F conjugative transfer system protein TraW", "go_ids": [], "go_terms": [], "name": "TraW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014115": {"description": "Type-F conjugative transfer system protein TrbI", "go_ids": [], "go_terms": [], "name": "TrbI_Ftype", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014116": {"description": "Cytochrome c oxidase cbb3 type, accessory protein FixG", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Cyt_c_oxidase_cbb3_FixG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014117": {"description": "Type-IV secretion system protein TraC", "go_ids": [], "go_terms": [], "name": "TraC-F-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014118": {"description": "Type IV conjugative transfer system protein TraV", "go_ids": [], "go_terms": [], "name": "T4SS_TraV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014119": {"description": "Heptaprenyl diphosphate synthase component II", "go_ids": [], "go_terms": [], "name": "GerC3_HepT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014121": {"description": "Type-F conjugative transfer system mating-pair stabilisation protein TraN", "go_ids": [], "go_terms": [], "name": "TraN_Ftype", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014122": {"description": "Demethylmenaquinone methyltransferase", "go_ids": ["GO:0008168", "GO:0009234"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0009234:menaquinone biosynthetic process:P"], "name": "MenG_heptapren", "pathway_ids": ["PWY-5895", "PWY-5839", "PWY-5891", "PWY-5892", "PWY-5844", "PWY-5849", "PWY-5890", "PWY-7996"], "pathways": ["PWY-5895:t:menaquinol-13 biosynthesis", "PWY-5839:t:menaquinol-7 biosynthesis", "PWY-5891:t:menaquinol-11 biosynthesis", "PWY-5892:t:menaquinol-12 biosynthesis", "PWY-5844:t:menaquinol-9 biosynthesis", "PWY-5849:t:menaquinol-6 biosynthesis", "PWY-5890:t:menaquinol-10 biosynthesis", "PWY-7996:t:menaquinol-4 biosynthesis I"], "type": "Family"}, "IPR014123": {"description": "Superoxide dismutase, Nickel-type", "go_ids": ["GO:0004784", "GO:0016151", "GO:0016209"], "go_terms": ["GO:0004784:superoxide dismutase activity:F", "GO:0016151:nickel cation binding:F", "GO:0016209:antioxidant activity:F"], "name": "Superoxide_dismutase_Ni-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014124": {"description": "Peptidase S26A, superoxide dismutase maturation protease, nickel-type", "go_ids": [], "go_terms": [], "name": "Pept_S26A_Sod_Ni_maturase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014125": {"description": "Type-F conjugative transfer system pilin acetylase TraX", "go_ids": [], "go_terms": [], "name": "TraX_Ftype", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014126": {"description": "Type-F conjugative transfer system secretin TraK", "go_ids": [], "go_terms": [], "name": "TraK_Ftype", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014127": {"description": "Conserved hypothetical protein CHP02757", "go_ids": [], "go_terms": [], "name": "CHP02757", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014128": {"description": "Type IV secretion system coupling protein TraD", "go_ids": [], "go_terms": [], "name": "TraD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014129": {"description": "Conjugative transfer relaxase protein TraI", "go_ids": [], "go_terms": [], "name": "Conjug_relaxase_TraI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014131": {"description": "Internal scaffolding protein VP3", "go_ids": [], "go_terms": [], "name": "VP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014132": {"description": "Sporulation polysaccharide deacetylase PdaB-like", "go_ids": [], "go_terms": [], "name": "PdaB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014133": {"description": "Cryptochrome DASH", "go_ids": ["GO:0003913", "GO:0006281"], "go_terms": ["GO:0003913:DNA photolyase activity:F", "GO:0006281:DNA repair:P"], "name": "Cry_DASH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014134": {"description": "Cryptochrome, plant", "go_ids": ["GO:0009882", "GO:0009785"], "go_terms": ["GO:0009882:blue light photoreceptor activity:F", "GO:0009785:blue light signaling pathway:P"], "name": "Cryptochrome_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014135": {"description": "Conjugal transfer protein TraG-like", "go_ids": [], "go_terms": [], "name": "Ti-typ_conjug_TS_TraG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014136": {"description": "Ti-type conjugative transfer relaxase TraA", "go_ids": [], "go_terms": [], "name": "TraA_Ti", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014137": {"description": "Nickel import ATP-binding protein NikE", "go_ids": ["GO:0005886", "GO:0015413", "GO:0015675", "GO:0016151"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0015413:ABC-type nickel transporter activity:F", "GO:0015675:nickel cation transport:P", "GO:0016151:nickel cation binding:F"], "name": "Nickel_NikE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014138": {"description": "Nickel import ATP-binding protein NikD", "go_ids": ["GO:0005886", "GO:0015413", "GO:0015675", "GO:0016151"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0015413:ABC-type nickel transporter activity:F", "GO:0015675:nickel cation transport:P", "GO:0016151:nickel cation binding:F"], "name": "Nickel_NikD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014139": {"description": "Peptidase S26C, conjugative transfer signal peptidase TraF", "go_ids": ["GO:0042597"], "go_terms": ["GO:0042597:periplasmic space:C"], "name": "Peptidase_S26C_TraF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014140": {"description": "ATP-dependent helicase/deoxyribonuclease AddB", "go_ids": ["GO:0016788", "GO:0000724"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F", "GO:0000724:double-strand break repair via homologous recombination:P"], "name": "AddB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014141": {"description": "DNA helicase subunit RexB", "go_ids": ["GO:0016788", "GO:0016817"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F", "GO:0016817:hydrolase activity, acting on acid anhydrides:F"], "name": "DNA_helicase_suRexB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014142": {"description": "P-type conjugative transfer protein TrbG", "go_ids": [], "go_terms": [], "name": "TrbG_Ti", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014143": {"description": "DNA ligase D", "go_ids": [], "go_terms": [], "name": "NHEJ_ligase_prk", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014144": {"description": "DNA ligase D, 3'-phosphoesterase domain", "go_ids": [], "go_terms": [], "name": "LigD_PE_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014145": {"description": "DNA ligase D, polymerase domain", "go_ids": [], "go_terms": [], "name": "LigD_pol_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014146": {"description": "DNA ligase D, ligase domain", "go_ids": [], "go_terms": [], "name": "LigD_ligase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014147": {"description": "Type IV conjugative transfer protein TrbJ", "go_ids": [], "go_terms": [], "name": "T4SS_TrbJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014148": {"description": "P-type conjugative transfer protein VirB9", "go_ids": [], "go_terms": [], "name": "VirB9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014149": {"description": "Conjugative transfer, TrbB", "go_ids": ["GO:0005737", "GO:0005524"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0005524:ATP binding:F"], "name": "Conjug-transfer_TrbB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014150": {"description": "Conjugal transfer, TrbL", "go_ids": [], "go_terms": [], "name": "Conjugal_tfr_TrbL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014151": {"description": "DNA helicase, AddA type", "go_ids": [], "go_terms": [], "name": "DNA_helicase_AddA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014152": {"description": "ATP-dependent helicase/nuclease subunit A", "go_ids": ["GO:0006302", "GO:0003678"], "go_terms": ["GO:0006302:double-strand break repair:P", "GO:0003678:DNA helicase activity:F"], "name": "AddA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014153": {"description": "Double-strand break repair protein AddB", "go_ids": [], "go_terms": [], "name": "Ds_break_AddB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014154": {"description": "Global transcriptional regulator CodY", "go_ids": ["GO:0045892", "GO:0003677", "GO:0003700", "GO:0005525"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0005525:GTP binding:F"], "name": "CodY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014155": {"description": "Type IV secretion system protein VirB11", "go_ids": ["GO:0044097", "GO:0043684"], "go_terms": ["GO:0044097:secretion by the type IV secretion system:P", "GO:0043684:type IV secretion system complex:C"], "name": "VirB11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014156": {"description": "Nickel ABC transporter, permease subunit NikB", "go_ids": ["GO:0015099", "GO:0035444"], "go_terms": ["GO:0015099:nickel cation transmembrane transporter activity:F", "GO:0035444:nickel cation transmembrane transport:P"], "name": "Nickel_NikB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014157": {"description": "Nickel ABC transporter, permease subunit NikC", "go_ids": ["GO:0015099", "GO:0016020"], "go_terms": ["GO:0015099:nickel cation transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "Nickel_NikC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014158": {"description": "Type IV secretion system protein VirB5-like", "go_ids": [], "go_terms": [], "name": "VirB5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014159": {"description": "Protocatechuate 4,5-dioxygenase, alpha subunit", "go_ids": [], "go_terms": [], "name": "PCA_LigA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014160": {"description": "Nickel-responsive transcriptional regulator NikR, proteobacteria", "go_ids": ["GO:0016151", "GO:0010045"], "go_terms": ["GO:0016151:nickel cation binding:F", "GO:0010045:response to nickel cation:P"], "name": "Nickel_NikR_proteobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014161": {"description": "Tol-Pal system, TolA", "go_ids": ["GO:0043213", "GO:0016020", "GO:0019534"], "go_terms": ["GO:0043213:bacteriocin transport:P", "GO:0016020:membrane:C", "GO:0019534:toxin transmembrane transporter activity:F"], "name": "Tol-Pal_TolA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014162": {"description": "Cell division coordinator CpoB, C-terminal", "go_ids": [], "go_terms": [], "name": "CpoB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014163": {"description": "Tol-Pal system, TolQ", "go_ids": ["GO:0016020", "GO:0043213"], "go_terms": ["GO:0016020:membrane:C", "GO:0043213:bacteriocin transport:P"], "name": "Tol-Pal_TolQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014164": {"description": "TonB-system energizer ExbB type-1", "go_ids": ["GO:0016020", "GO:0055085", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "TonB_ExbB_1", "pathway_ids": ["R-HSA-9638334", "R-HSA-9927020", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9927020:r:Heme assimilation", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR014165": {"description": "4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase", "go_ids": ["GO:0047443"], "go_terms": ["GO:0047443:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity:F"], "name": "LigK_PcmE", "pathway_ids": ["PWY-6339", "PWY-7701"], "pathways": ["PWY-6339:t:syringate degradation", "PWY-7701:t:4-hydroxy-4-methyl-L-glutamate biosynthesis"], "type": "Family"}, "IPR014166": {"description": "Tol-Pal system-associated acyl-CoA thioesterase", "go_ids": ["GO:0016790"], "go_terms": ["GO:0016790:thiolester hydrolase activity:F"], "name": "Tol-Pal_acyl-CoA_thioesterase", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis"], "type": "Family"}, "IPR014167": {"description": "Tol-Pal system protein TolB", "go_ids": ["GO:0017038", "GO:0042597"], "go_terms": ["GO:0017038:protein import:P", "GO:0042597:periplasmic space:C"], "name": "Tol-Pal_TolB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014168": {"description": "Tol-Pal system protein TolR", "go_ids": ["GO:0016020", "GO:0015031"], "go_terms": ["GO:0016020:membrane:C", "GO:0015031:protein transport:P"], "name": "Tol-Pal_TolR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014169": {"description": "Peptidoglycan-associated lipoprotein, C-terminal", "go_ids": ["GO:0009279"], "go_terms": ["GO:0009279:cell outer membrane:C"], "name": "Pal_lipo_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014170": {"description": "TonB system transport protein ExbD type-1", "go_ids": ["GO:0016020", "GO:0055085"], "go_terms": ["GO:0016020:membrane:C", "GO:0055085:transmembrane transport:P"], "name": "TonB_ExbD_1", "pathway_ids": ["R-HSA-9638334", "R-HSA-9927020", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9927020:r:Heme assimilation", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR014171": {"description": "TonB system transport protein ExbD type-2", "go_ids": ["GO:0055085", "GO:0016020"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0016020:membrane:C"], "name": "TonB_ExbD_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014172": {"description": "TonB-system energizer ExbB type-2", "go_ids": ["GO:0055085", "GO:0016020"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0016020:membrane:C"], "name": "TonB_ExbB_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014173": {"description": "Peptidase C11, Clostripain Clostridium species", "go_ids": [], "go_terms": [], "name": "Pept_C11_CLOspp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014174": {"description": "CRISPR-associated protein Cas6/Cmx6", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cas6/Cmx6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014175": {"description": "Conserved hypothetical protein CHP02808", "go_ids": [], "go_terms": [], "name": "CHP02808", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014176": {"description": "Phasin, subfamily 3", "go_ids": [], "go_terms": [], "name": "Phasin_subfam-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014177": {"description": "Putative formate dehydrogenase, TAT signal-containing", "go_ids": [], "go_terms": [], "name": "Formate_DH_TAT-contain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014178": {"description": "Fatty acid response transcription factor FadR", "go_ids": ["GO:0000062", "GO:0003677", "GO:0003700", "GO:0019217"], "go_terms": ["GO:0000062:fatty-acyl-CoA binding:F", "GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0019217:regulation of fatty acid metabolic process:P"], "name": "FA-response_TF_FadR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014179": {"description": "PfaD-like, TIM-barrel domain", "go_ids": [], "go_terms": [], "name": "PfaD-like_TIM-barrel", "pathway_ids": ["PWY-8049", "PWY-8012", "PWY-8438", "PWY-8047", "PWY-6799", "PWY-4381"], "pathways": ["PWY-8049:t:pederin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-4381:t:fatty acid biosynthesis initiation (type II)"], "type": "Domain"}, "IPR014180": {"description": "D-galactosamine-6-phosphate deaminase AgaS", "go_ids": ["GO:0016853"], "go_terms": ["GO:0016853:isomerase activity:F"], "name": "AgaS", "pathway_ids": ["PWY-7512", "PWY-7770", "PWY-2942", "PWY-8037", "PWY-7077", "PWY-7621", "PWY-7006", "PWY-7357", "PWY-7395"], "pathways": ["PWY-7512:t:3,5,6-trichloro-2-pyridinol degradation", "PWY-7770:t:indolmycin biosynthesis", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8037:t:saliniketal A biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-7006:t:4-amino-3-hydroxybenzoate degradation", "PWY-7357:t:thiamine diphosphate formation from pyrithiamine and oxythiamine (yeast)", "PWY-7395:t:D-galactosamine and N-acetyl-D-galactosamine degradation"], "type": "Family"}, "IPR014181": {"description": "Omega-3 polyunsaturated fatty acid synthase-like", "go_ids": [], "go_terms": [], "name": "Omega3_polyunsat_FA_synth-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014182": {"description": "Alcohol dehydrogenase, zinc-binding type 1", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "ADH_Zn_typ-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014183": {"description": "Alcohol dehydrogenase class III", "go_ids": ["GO:0008270", "GO:0051903", "GO:0046294"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0051903:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity:F", "GO:0046294:formaldehyde catabolic process:P"], "name": "ADH_3", "pathway_ids": ["PWY-7489", "PWY-5480", "PWY-7615", "PWY-7757", "PWY-7337", "PWY-1801", "PWY-6883", "PWY-7694", "PWY-7693", "PWY-6672", "PWY-7568", "PWY-3162", "PWY-5316", "PWY-5818", "PWY-7787", "PWY-6080", "PWY-7667", "PWY-6926", "PWY-6539", "PWY-5978", "PWY-6634", "PWY-5830", "PWY-8383", "PWY-6322", "PWY-8411", "PWY-7338", "PWY-6704", "PWY-6583", "PWY-8139", "PWY-5652", "PWY-8374", "PWY-7342", "PWY-7774", "PWY-6693", "PWY-7354", "PWY-7531", "PWY-7547", "PWY-6738", "PWY-8012", "PWY-5078", "PWY-6682", "PWY-6333", "PWY-7331", "PWY-5057", "PWY-7104", "PWY-7490", "PWY-6920", "PWY-7811", "PWY-7339", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7657", "PWY-8419", "PWY-5271", "PWY-7734", "PWY-7682", "PWY-7541", "PWY-6626", "PWY-6391", "PWY-6638", "PWY-8152", "PWY-3261", "PWY-5076", "PWY-8464", "PWY-6733", "PWY-321", "PWY-6637", "PWY-7660", "PWY-6944", "PWY-7288", "PWY-6659", "PWY-7301", "PWY-8367", "PWY-6786", "PWY-6973", "PWY-7111", "PWY-2541", "PWYG-321", "PWY-5883", "PWY-6053", "PWY-6802", "PWY-7042", "PWY-7742", "PWY-7621", "PWY-7798", "PWY-8410", "PWY-5867", "PWY-8214", "PWY-7554", "PWY-8409", "PWY-7814", "PWY-7557", "PWY-8297", "PWY-7403", "PWY-6342", "PWY-7241", "PWY-6948", "PWY-7610", "PWY-8155", "PWY-6974", "PWY-2601", "PWY-7396", "PWY-7695", "PWY-7304", "PWY-8058", "PWY-8366", "PWY-7043", "PWY-7520", "PWY-6863", "PWY-6976", "PWY-3722", "PWY-5082", "PWY-7352", "PWY-6989", "PWY-6061", "PWY-8408", "PWY-7649", "PWY-8397", "PWY-7613", "PWY-5782", "PWY-741", "PWY-7333", "PWY-5101", "PWY-6587", "PWY-7775", "PWY-1121", "PWY-6871", "PWY-7606", "PWY-7741", "PWY-7779", "R-SPO-5365859", "R-SCE-5365859", "R-DDI-71384", "R-DDI-5365859", "R-CEL-5365859", "R-SPO-2161541", "R-DME-2161541", "R-DDI-2161541", "R-DME-5365859", "R-RNO-71384", "R-SCE-71384", "R-HSA-71384", "R-CEL-71384", "R-SPO-71384", "R-CEL-2161541", "R-BTA-71384", "R-DME-71384", "R-SCE-2161541", "R-MMU-71384", "PWY-5882", "PWY-5848", "PWY-7045", "PWY-5751", "PWY-7825", "PWY-7788", "PWY-5666", "PWY-8132", "PWY-8426", "PWY-7013", "PWY-5392", "PWY-6627", "PWY-6946", "PWY-7300", "PWY-5079", "PWY-6392", "PWY-6945", "PWY-6302", "PWY-6313", "PWY-8238", "PWY-7948", "PWY-7689", "PWY-8029", "PWY-7321", "PWY-7340", "PWY-7385", "PWY-7440", "PWY-5486", "PWY-7726", "PWY-5972", "PWY-7692", "PWY-1186", "PWY-8370"], "pathways": ["PWY-7489:t:oryzalexin A, B, and C biosynthesis", "PWY-5480:t:pyruvate fermentation to ethanol I", "PWY-7615:t:pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)", "PWY-7757:t:bisphenol A degradation", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-1801:t:formaldehyde oxidation II (glutathione-dependent)", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7568:t:L-galactose degradation", "PWY-3162:t:L-tryptophan degradation V (side chain pathway)", "PWY-5316:t:nicotine biosynthesis", "PWY-5818:t:validamycin biosynthesis", "PWY-7787:t:L-threitol degradation", "PWY-6080:t:4-ethylphenol degradation (anaerobic)", "PWY-7667:t:apicidin biosynthesis", "PWY-6926:t:pyrethrin I biosynthesis", "PWY-6539:t:(Z)-phenylmethanethial S-oxide biosynthesis", "PWY-5978:t:kanosamine biosynthesis I", "PWY-6634:t:3-sulfopropanediol degradation I", "PWY-5830:t:CDP-ascarylose biosynthesis", "PWY-8383:t:myxochelin A and B biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-6704:t:L-ascorbate degradation IV", "PWY-6583:t:pyruvate fermentation to butanol I", "PWY-8139:t:CDP-6-deoxy-D-gulose biosynthesis", "PWY-5652:t:2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA", "PWY-8374:t:antimycin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7774:t:propane degradation I", "PWY-6693:t:D-galactose degradation IV", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-6738:t:pinitol biosynthesis I", "PWY-8012:t:mupirocin biosynthesis", "PWY-5078:t:L-isoleucine degradation II", "PWY-6682:t:dehydrophos biosynthesis", "PWY-6333:t:acetaldehyde biosynthesis I", "PWY-7331:t:UDP-N-acetyl-beta-L-quinovosamine biosynthesis", "PWY-5057:t:L-valine degradation II", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7490:t:patulin biosynthesis", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7657:t:dTDP-beta-L-digitoxose biosynthesis", "PWY-8419:t:L-canavanine degradation II", "PWY-5271:t:abscisic acid degradation to phaseic acid", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7682:t:arabidopyrone biosynthesis", "PWY-7541:t:1,2-propanediol biosynthesis from lactate (engineered)", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6391:t:meso-butanediol biosynthesis I", "PWY-6638:t:sulfolactate degradation III", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-3261:t:UDP-beta-L-rhamnose biosynthesis", "PWY-5076:t:L-leucine degradation III", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-6637:t:sulfolactate degradation II", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-6053:t:dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)", "PWY-6802:t:salidroside biosynthesis", "PWY-7042:t:the visual cycle (insects)", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-7798:t:protein S-nitrosylation and denitrosylation", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "PWY-5867:t:t-anethole biosynthesis", "PWY-8214:t:3-sulfopropanediol degradation II", "PWY-7554:t:heme d1 biosynthesis", "PWY-8409:t:cyathin biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-8297:t:6-diazo-5-oxo-L-norleucine biosynthesis", "PWY-7403:t:tetramethylpyrazine degradation", "PWY-6342:t:noradrenaline and adrenaline degradation", "PWY-7241:t:myo-inositol degradation II", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-8155:t:testosterone degradation (anaerobic)", "PWY-6974:t:dTDP-beta-L-olivose biosynthesis", "PWY-2601:t:isethionate degradation", "PWY-7396:t:butanol and isobutanol biosynthesis (engineered)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7304:t:3-amino-4,7-dihydroxy-coumarin biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8366:t:septacidin biosynthesis", "PWY-7043:t:11-cis-3-hydroxyretinal biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-3722:t:glycine betaine biosynthesis II (Gram-positive bacteria)", "PWY-5082:t:L-methionine degradation III", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6989:t:(S)-camphor degradation", "PWY-6061:t:bile acid biosynthesis, neutral pathway", "PWY-8408:t:erinacine biosynthesis", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWY-5782:t:2-keto-L-gulonate biosynthesis", "PWY-741:t:p-cymene degradation to p-cumate", "PWY-7333:t:UDP-N-acetyl-alpha-D-fucosamine biosynthesis", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-6587:t:pyruvate fermentation to ethanol III", "PWY-7775:t:propane degradation II", "PWY-1121:t:suberin monomers biosynthesis", "PWY-6871:t:3-methylbutanol biosynthesis (engineered)", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation", "R-SPO-5365859:r:RA biosynthesis pathway", "R-SCE-5365859:r:RA biosynthesis pathway", "R-DDI-71384:r:Ethanol oxidation", "R-DDI-5365859:r:RA biosynthesis pathway", "R-CEL-5365859:r:RA biosynthesis pathway", "R-SPO-2161541:r:Abacavir metabolism", "R-DME-2161541:r:Abacavir metabolism", "R-DDI-2161541:r:Abacavir metabolism", "R-DME-5365859:r:RA biosynthesis pathway", "R-RNO-71384:r:Ethanol oxidation", "R-SCE-71384:r:Ethanol oxidation", "R-HSA-71384:r:Ethanol oxidation", "R-CEL-71384:r:Ethanol oxidation", "R-SPO-71384:r:Ethanol oxidation", "R-CEL-2161541:r:Abacavir metabolism", "R-BTA-71384:r:Ethanol oxidation", "R-DME-71384:r:Ethanol oxidation", "R-SCE-2161541:r:Abacavir metabolism", "R-MMU-71384:r:Ethanol oxidation", "PWY-5882:t:epoxypseudoisoeugenol-2-methylbutanoate biosynthesis", "PWY-5848:t:cinchona alkaloids biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-5751:t:phenylethanol biosynthesis", "PWY-7825:t:juglone degradation", "PWY-7788:t:erythritol degradation II", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7013:t:(S)-propane-1,2-diol degradation", "PWY-5392:t:reductive TCA cycle II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-5079:t:L-phenylalanine degradation III", "PWY-6392:t:meso-butanediol biosynthesis II", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-6313:t:serotonin degradation", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-5486:t:pyruvate fermentation to ethanol II", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-7692:t:bikaverin biosynthesis", "PWY-1186:t:L-homomethionine biosynthesis", "PWY-8370:t:leporin B biosynthesis"], "type": "Family"}, "IPR014184": {"description": "Formaldehyde dehydrogenase, glutathione-independent", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "HCHO_DH_non_GSH", "pathway_ids": ["PWY-7616"], "pathways": ["PWY-7616:t:methanol oxidation to carbon dioxide"], "type": "Family"}, "IPR014185": {"description": "Glutathione-dependent formaldehyde-activating enzyme", "go_ids": ["GO:0008270", "GO:0046294", "GO:0051907"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0046294:formaldehyde catabolic process:P", "GO:0051907:S-(hydroxymethyl)glutathione synthase activity:F"], "name": "Formald_GSH", "pathway_ids": ["PWY-1801"], "pathways": ["PWY-1801:t:formaldehyde oxidation II (glutathione-dependent)"], "type": "Family"}, "IPR014186": {"description": "S-formylglutathione hydrolase", "go_ids": ["GO:0018738", "GO:0046294"], "go_terms": ["GO:0018738:S-formylglutathione hydrolase activity:F", "GO:0046294:formaldehyde catabolic process:P"], "name": "S-formylglutathione_hydrol", "pathway_ids": ["PWY-1801", "R-RNO-156590", "R-SCE-156590", "R-HSA-156590", "R-SSC-156590", "R-MMU-156590", "R-BTA-156590"], "pathways": ["PWY-1801:t:formaldehyde oxidation II (glutathione-dependent)", "R-RNO-156590:r:Glutathione conjugation", "R-SCE-156590:r:Glutathione conjugation", "R-HSA-156590:r:Glutathione conjugation", "R-SSC-156590:r:Glutathione conjugation", "R-MMU-156590:r:Glutathione conjugation", "R-BTA-156590:r:Glutathione conjugation"], "type": "Family"}, "IPR014187": {"description": "Alcohol dehydrogenase, zinc-binding type 2", "go_ids": [], "go_terms": [], "name": "ADH_Zn_typ-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014188": {"description": "Acrylyl-CoA reductase AcuI", "go_ids": [], "go_terms": [], "name": "Acrylyl-CoA_reductase_AcuI", "pathway_ids": ["PWY-8180", "PWY-5743", "PWY-5744", "PWY-5789"], "pathways": ["PWY-8180:t:acrylate degradation II", "PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5744:t:glyoxylate assimilation", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle"], "type": "Family"}, "IPR014189": {"description": "Quinone oxidoreductase PIG3/PKS9", "go_ids": [], "go_terms": [], "name": "Quinone_OxRdtase_PIG3/PKS9", "pathway_ids": ["R-HSA-6803205"], "pathways": ["R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "type": "Family"}, "IPR014190": {"description": "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase", "go_ids": ["GO:0005737", "GO:0032440", "GO:0047522"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0032440:2-alkenal reductase [NAD(P)H] activity:F", "GO:0047522:15-oxoprostaglandin 13-reductase [NAD(P)+] activity:F"], "name": "PTGR1", "pathway_ids": ["PWY-8399", "PWY-8396", "PWY-8397", "R-HSA-2142700", "R-HSA-2142691"], "pathways": ["PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-8397:t:arachidonate metabolites biosynthesis", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "type": "Family"}, "IPR014191": {"description": "Anaerobic ribonucleoside-triphosphate reductase activator", "go_ids": [], "go_terms": [], "name": "Anaer_RNR_activator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014193": {"description": "Uncharacterised domain CHP02828, putative membrane fusion protein", "go_ids": [], "go_terms": [], "name": "CHP02828_mem_fusion", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014194": {"description": "Sporulation stage III, protein AE", "go_ids": [], "go_terms": [], "name": "Spore_III_AE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014195": {"description": "Stage III sporulation protein AG", "go_ids": [], "go_terms": [], "name": "SpoIIIAG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014196": {"description": "Stage II sporulation protein M", "go_ids": [], "go_terms": [], "name": "SpoIIM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014197": {"description": "Sporulation protein YunB", "go_ids": [], "go_terms": [], "name": "Sporulation_prot_YunB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014198": {"description": "Stage III sporulation protein AB", "go_ids": [], "go_terms": [], "name": "Spore_III_AB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014199": {"description": "Sporulation protein YtxC", "go_ids": [], "go_terms": [], "name": "Spore_YtxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014200": {"description": "RNA polymerase sigma-E type", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma-E", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014201": {"description": "Sporulation stage IV, protein A", "go_ids": ["GO:0005524", "GO:0043934", "GO:0016887"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0043934:sporulation:P", "GO:0016887:ATP hydrolysis activity:F"], "name": "Spore_IV_A", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR014202": {"description": "Sporulation stage II, protein R", "go_ids": [], "go_terms": [], "name": "Spore_II_R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014203": {"description": "Sporulation stage V, protein AC", "go_ids": [], "go_terms": [], "name": "Spore_V_AC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014204": {"description": "Sporulation stage V, protein AE", "go_ids": [], "go_terms": [], "name": "Spore_V_AE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014205": {"description": "Sporulation protein YtaF", "go_ids": [], "go_terms": [], "name": "Spore_YtaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014206": {"description": "Cytochrome o ubiquinol oxidase, subunit III", "go_ids": ["GO:0019646", "GO:0009486"], "go_terms": ["GO:0019646:aerobic electron transport chain:P", "GO:0009486:cytochrome bo3 ubiquinol oxidase activity:F"], "name": "Cyt_c_ubiqinol_oxidase_su3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014207": {"description": "Cytochrome o ubiquinol oxidase, subunit I", "go_ids": ["GO:0016682"], "go_terms": ["GO:0016682:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor:F"], "name": "Cyt_c_ubiqinol_oxidase_su1", "pathway_ids": ["PWY-7544"], "pathways": ["PWY-7544:t:pyruvate to cytochrome bo oxidase electron transfer"], "type": "Family"}, "IPR014208": {"description": "Sporulation stage III, transcriptional regulator SpoIIID", "go_ids": [], "go_terms": [], "name": "Spore_III_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014209": {"description": "RNA polymerase sigma-K type", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma-K", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014210": {"description": "Cytochrome o ubiquinol oxidase subunit IV", "go_ids": ["GO:0016020", "GO:0015990", "GO:0009486"], "go_terms": ["GO:0016020:membrane:C", "GO:0015990:electron transport coupled proton transport:P", "GO:0009486:cytochrome bo3 ubiquinol oxidase activity:F"], "name": "Cyt_o_ubiqinol_oxidase_su4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014211": {"description": "Stage III sporulation protein AD", "go_ids": [], "go_terms": [], "name": "Spore_III_AD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014212": {"description": "RNA polymerase sigma-G type", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma-G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014213": {"description": "Sporulation stage V, protein T", "go_ids": [], "go_terms": [], "name": "SpoVT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014214": {"description": "Dipicolinic acid synthetase, subunit B", "go_ids": [], "go_terms": [], "name": "Dipicolinic_acid_synth_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014215": {"description": "Dipicolinic acid synthetase subunit A", "go_ids": [], "go_terms": [], "name": "Dipicolinic_acid_synth_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014216": {"description": "ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD", "go_ids": ["GO:0042883", "GO:0140359", "GO:0005524", "GO:0016020"], "go_terms": ["GO:0042883:L-cysteine transport:P", "GO:0140359:ABC-type transporter activity:F", "GO:0005524:ATP binding:F", "GO:0016020:membrane:C"], "name": "ABC_transptr_CydD", "pathway_ids": ["PWY-6409", "PWY-8419"], "pathways": ["PWY-6409:t:pyoverdine I biosynthesis", "PWY-8419:t:L-canavanine degradation II"], "type": "Family"}, "IPR014217": {"description": "Sporulation stage III, protein AA", "go_ids": [], "go_terms": [], "name": "Spore_III_AA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014218": {"description": "RNA polymerase sigma-H type", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma-H", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014219": {"description": "SpoIVB peptidase", "go_ids": [], "go_terms": [], "name": "SpoIVB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014220": {"description": "Small acid-soluble spore protein, SspJ", "go_ids": [], "go_terms": [], "name": "SASP_SspJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014221": {"description": "Stage II sporulation protein E", "go_ids": ["GO:0004722"], "go_terms": ["GO:0004722:protein serine/threonine phosphatase activity:F"], "name": "SpoII_E", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014222": {"description": "Cytochrome c oxidase, subunit II", "go_ids": ["GO:0016491", "GO:0016020"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0016020:membrane:C"], "name": "Cyt_c_oxidase_su2", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279", "R-DDI-9837999", "R-GGA-9707564", "R-HSA-5419276", "R-DRE-611105", "R-DME-9707564", "R-GGA-9864848", "R-RNO-5628897", "R-DRE-9864848", "R-RNO-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-DME-611105", "R-BTA-5628897", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-GGA-5419276", "R-DME-9864848", "R-RNO-5419276", "R-GGA-5628897", "R-BTA-611105", "R-HSA-9707564", "R-GGA-611105", "R-MMU-5628897", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9837999", "R-MMU-9864848", "R-BTA-5419276", "R-DRE-9707564", "R-DRE-5419276", "R-DRE-5628897", "R-RNO-9864848", "R-MMU-9707564", "R-DME-5628897", "R-BTA-9707564"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DRE-611105:r:Respiratory electron transport", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-GGA-9864848:r:Complex IV assembly", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-611105:r:Respiratory electron transport", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-DME-9864848:r:Complex IV assembly", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-GGA-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DRE-5419276:r:Mitochondrial translation termination", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR014223": {"description": "Glutathione/L-cysteine transport system ATP-binding/permease protein CydC/D", "go_ids": ["GO:0045454", "GO:0034775", "GO:0016020", "GO:0042626"], "go_terms": ["GO:0045454:cell redox homeostasis:P", "GO:0034775:glutathione transmembrane transport:P", "GO:0016020:membrane:C", "GO:0042626:ATPase-coupled transmembrane transporter activity:F"], "name": "ABC_CydC/D", "pathway_ids": ["PWY-6409", "PWY-8419"], "pathways": ["PWY-6409:t:pyoverdine I biosynthesis", "PWY-8419:t:L-canavanine degradation II"], "type": "Family"}, "IPR014224": {"description": "Spore cortex-lytic enzyme SleB", "go_ids": ["GO:0009847", "GO:0003824"], "go_terms": ["GO:0009847:spore germination:P", "GO:0003824:catalytic activity:F"], "name": "Spore_cortex_SleB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014225": {"description": "Sporulation stage II, protein D firmicutes", "go_ids": [], "go_terms": [], "name": "Spore_II_D_firmicutes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014226": {"description": "Sporulation integral membrane protein YlbJ", "go_ids": [], "go_terms": [], "name": "Spore_IM_YlbJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014227": {"description": "Putative transport protein YtvI-like", "go_ids": [], "go_terms": [], "name": "YtvI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014228": {"description": "Putative polysaccharide deacetylase SwsB", "go_ids": [], "go_terms": [], "name": "SwsB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014229": {"description": "Spore protein GerW", "go_ids": [], "go_terms": [], "name": "GerW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014230": {"description": "Sporulation protein YhbH", "go_ids": [], "go_terms": [], "name": "Spore_YhbH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014231": {"description": "Sporulation protein YpjB", "go_ids": [], "go_terms": [], "name": "Spore_YpjB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014232": {"description": "Sporulation stage V, protein K", "go_ids": [], "go_terms": [], "name": "Spore_V_K", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014233": {"description": "Quinol oxidase subunit I", "go_ids": ["GO:0005507", "GO:0016020", "GO:0016682", "GO:0020037"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0016020:membrane:C", "GO:0016682:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor:F", "GO:0020037:heme binding:F"], "name": "QoxB", "pathway_ids": ["PWY-5787", "PWY-5780", "PWY-5399", "PWY-7079", "PWY-5476", "PWY-5439", "PWY-5404"], "pathways": ["PWY-5787:t:oligomeric urushiol biosynthesis", "PWY-5780:t:hypericin biosynthesis", "PWY-5399:t:betacyanin biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-5476:t:cornusiin E biosynthesis", "PWY-5439:t:betacyanin biosynthesis (via dopamine)", "PWY-5404:t:betaxanthin biosynthesis (via dopaxanthin)"], "type": "Family"}, "IPR014234": {"description": "N-acetylmuramoyl-L-alanine amidase CwlD", "go_ids": [], "go_terms": [], "name": "Spore_CwlD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014235": {"description": "Peptidoglycan-N-acetylmuramic acid deacetylase PdaA", "go_ids": [], "go_terms": [], "name": "Spore_PdaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014236": {"description": "RNA polymerase sigma-F type", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma-F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014237": {"description": "Anti-sigma F factor antagonist", "go_ids": ["GO:0006355", "GO:0030435", "GO:0045152"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0030435:sporulation resulting in formation of a cellular spore:P", "GO:0045152:antisigma factor binding:F"], "name": "Anti-sigma_F_ant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014238": {"description": "Sporulation protein YlmC/YmxH", "go_ids": [], "go_terms": [], "name": "Spore_YlmC/YmxH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014239": {"description": "Sporulation protein YpeB, PepSY1 and PepSY2 domains", "go_ids": ["GO:0009847"], "go_terms": ["GO:0009847:spore germination:P"], "name": "YpeB_PepSY1-2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014240": {"description": "Regulatory protein, YteA family", "go_ids": [], "go_terms": [], "name": "YteA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014241": {"description": "Cytochrome c oxidase, subunit I bacterial type", "go_ids": ["GO:0004129", "GO:0015990"], "go_terms": ["GO:0004129:cytochrome-c oxidase activity:F", "GO:0015990:electron transport coupled proton transport:P"], "name": "Cyt_c_oxidase_su1_bac", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)"], "type": "Family"}, "IPR014243": {"description": "Prespore-specific transcriptional regulator RsfA-like", "go_ids": [], "go_terms": [], "name": "RsfA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014244": {"description": "RNA polymerase sigma-I type", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma-I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014245": {"description": "Sporulation stage III, protein AF", "go_ids": [], "go_terms": [], "name": "Spore_III_AF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014246": {"description": "Quinol oxidase subunit III", "go_ids": ["GO:0042773", "GO:0016020", "GO:0009055"], "go_terms": ["GO:0042773:ATP synthesis coupled electron transport:P", "GO:0016020:membrane:C", "GO:0009055:electron transfer activity:F"], "name": "QoxC", "pathway_ids": ["PWY-5787", "PWY-5780", "PWY-5399", "PWY-7079", "PWY-5476", "PWY-5439", "PWY-5404"], "pathways": ["PWY-5787:t:oligomeric urushiol biosynthesis", "PWY-5780:t:hypericin biosynthesis", "PWY-5399:t:betacyanin biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-5476:t:cornusiin E biosynthesis", "PWY-5439:t:betacyanin biosynthesis (via dopamine)", "PWY-5404:t:betaxanthin biosynthesis (via dopaxanthin)"], "type": "Family"}, "IPR014247": {"description": "Sporulation lipoprotein YhcN/YlaJ", "go_ids": ["GO:0030435"], "go_terms": ["GO:0030435:sporulation resulting in formation of a cellular spore:P"], "name": "Spore_lipoprot_YhcN/YlaJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014248": {"description": "Spore coat assembly protein SafA", "go_ids": [], "go_terms": [], "name": "Spore_coat_assembly_SafA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014249": {"description": "Sporulation stage V protein B", "go_ids": [], "go_terms": [], "name": "Spore_V_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014250": {"description": "Quinol oxidase subunit IV", "go_ids": ["GO:0016020", "GO:0016682", "GO:0042773"], "go_terms": ["GO:0016020:membrane:C", "GO:0016682:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor:F", "GO:0042773:ATP synthesis coupled electron transport:P"], "name": "QoxD", "pathway_ids": ["PWY-5787", "PWY-5780", "PWY-5399", "PWY-7079", "PWY-5476", "PWY-5439", "PWY-5404"], "pathways": ["PWY-5787:t:oligomeric urushiol biosynthesis", "PWY-5780:t:hypericin biosynthesis", "PWY-5399:t:betacyanin biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-5476:t:cornusiin E biosynthesis", "PWY-5439:t:betacyanin biosynthesis (via dopamine)", "PWY-5404:t:betaxanthin biosynthesis (via dopaxanthin)"], "type": "Family"}, "IPR014251": {"description": "Sporulation protease LonB", "go_ids": [], "go_terms": [], "name": "Spore_LonB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014252": {"description": "Sporulation protease LonC", "go_ids": [], "go_terms": [], "name": "Spore_LonC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014253": {"description": "Spore coat protein YsxE", "go_ids": [], "go_terms": [], "name": "Spore_coat_YsxE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014254": {"description": "Spore coat putative kinase YutH", "go_ids": [], "go_terms": [], "name": "Spore_coat_YutH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014255": {"description": "Spore coat protein CotS", "go_ids": [], "go_terms": [], "name": "Spore_coat_CotS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014256": {"description": "Sporulation stage VI, protein D", "go_ids": [], "go_terms": [], "name": "Spore_VI_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014257": {"description": "Cytochrome c oxidase, subunit IV bacillaceae", "go_ids": [], "go_terms": [], "name": "Cyt_c_oxidase_su4_bacillaceae", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014258": {"description": "CAP domain, YkwD-like", "go_ids": [], "go_terms": [], "name": "CAP_domain_YkwD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014259": {"description": "Anaerobic sulfite reductase subunit A", "go_ids": [], "go_terms": [], "name": "AsrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014260": {"description": "Anaerobic sulfite reductase subunit B", "go_ids": [], "go_terms": [], "name": "AsrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014261": {"description": "Sulphite reductase, subunit C", "go_ids": [], "go_terms": [], "name": "Sulphite_reductase_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014262": {"description": "HAF repeat", "go_ids": [], "go_terms": [], "name": "HAF_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR014263": {"description": "Methanolan biosynthesis EpsI", "go_ids": [], "go_terms": [], "name": "Methanolan_biosynth_EpsI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014264": {"description": "PEP-CTERM-box response regulator transcription factor", "go_ids": [], "go_terms": [], "name": "PEP-CTERM_resp_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014265": {"description": "XrtA/PEP-CTERM system histidine kinase PrsK", "go_ids": [], "go_terms": [], "name": "XrtA/PrsK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014266": {"description": "PEP-CTERM system TPR-repeat protein PrsT", "go_ids": [], "go_terms": [], "name": "PEP-CTERM_TPR_PrsT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014267": {"description": "Glycosyltransferase GtfA", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "GtfA", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR014268": {"description": "GtfB", "go_ids": ["GO:0031647"], "go_terms": ["GO:0031647:regulation of protein stability:P"], "name": "GtfB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014269": {"description": "Accessory Sec system protein translocase subunit SecY2", "go_ids": [], "go_terms": [], "name": "SecY2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014270": {"description": "PEP-CTERM integral membrane protein", "go_ids": [], "go_terms": [], "name": "PEP-CTERM_IMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014271": {"description": "Conserved hypothetical protein CHP02922", "go_ids": [], "go_terms": [], "name": "CHP02922", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014272": {"description": "ATPase, V0 complex, C subunit", "go_ids": ["GO:0046961", "GO:0033179"], "go_terms": ["GO:0046961:proton-transporting ATPase activity, rotational mechanism:F", "GO:0033179:proton-transporting V-type ATPase, V0 domain:C"], "name": "ATPase_V0-cplx_csu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014273": {"description": "Isocitrate dehydrogenase, bacteria-type", "go_ids": ["GO:0004450", "GO:0006097", "GO:0006099", "GO:0046872"], "go_terms": ["GO:0004450:isocitrate dehydrogenase (NADP+) activity:F", "GO:0006097:glyoxylate cycle:P", "GO:0006099:tricarboxylic acid cycle:P", "GO:0046872:metal ion binding:F"], "name": "Isocitrate_DH_bac-typ", "pathway_ids": ["PWY-6549", "PWY-7254", "PWY-7124", "PWY-5913", "PWY-7268", "PWY-6728", "PWY-6969"], "pathways": ["PWY-6549:t:nitrogen remobilization from senescing leaves", "PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7268:t:cytosolic NADPH production (yeast)", "PWY-6728:t:methylaspartate cycle", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)"], "type": "Family"}, "IPR014274": {"description": "Peptidyl-prolyl cis-trans isomerase, EpsD-type", "go_ids": [], "go_terms": [], "name": "PPIase_EpsD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014275": {"description": "ATPase, A1A0, subunit H", "go_ids": [], "go_terms": [], "name": "ATPase_A1A0-cplx_hsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014276": {"description": "2-oxoglutarate dehydrogenase, E2 component", "go_ids": [], "go_terms": [], "name": "2-oxoglutarate_DH_E2", "pathway_ids": ["R-HSA-1222541"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis"], "type": "Family"}, "IPR014277": {"description": "Orc1/Cdc6-type DNA replication protein, archaea", "go_ids": [], "go_terms": [], "name": "Orc1/Cdc6_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014278": {"description": "Nitrogenase iron-iron, delta subunit", "go_ids": ["GO:0005506", "GO:0009399", "GO:0016163", "GO:0051536"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Nase_Fe-Fe_dsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014279": {"description": "Nitrogenase vanadium-iron, delta subunit", "go_ids": ["GO:0009399", "GO:0016163", "GO:0046872"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F", "GO:0046872:metal ion binding:F"], "name": "Nase_V-Fe_dsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014280": {"description": "Nitrogenase iron-iron, beta subunit", "go_ids": ["GO:0009399", "GO:0016163"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F"], "name": "Nase_Fe-Fe_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014281": {"description": "Nitrogenase vanadium-iron protein beta chain", "go_ids": ["GO:0009399", "GO:0016163", "GO:0016613", "GO:0051536"], "go_terms": ["GO:0009399:nitrogen fixation:P", "GO:0016163:nitrogenase activity:F", "GO:0016613:vanadium-iron nitrogenase complex:C", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Nase_VnfK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014282": {"description": "Nitrogen fixation protein NifM", "go_ids": [], "go_terms": [], "name": "Nitrogen_fix_NifM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014283": {"description": "Ferredoxin III 4[4Fe-4S], nif-specific", "go_ids": [], "go_terms": [], "name": "FdIII_4_nif", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014284": {"description": "RNA polymerase sigma-70-like domain", "go_ids": ["GO:0003700", "GO:0006352", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RNA_pol_sigma-70_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014285": {"description": "Nitrogen fixation negative regulator NifL", "go_ids": ["GO:0007165", "GO:0009399"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0009399:nitrogen fixation:P"], "name": "N_fixation_neg-reg_NifL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014286": {"description": "RNA polymerase sigma-70 RpoE type", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma70_RpoE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014287": {"description": "Nitrogenase iron-iron, accessory protein AnfO", "go_ids": [], "go_terms": [], "name": "Nase_Fe-Fe_AnfO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014288": {"description": "RNA polymerase sigma-B factor", "go_ids": ["GO:0016987"], "go_terms": ["GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma-B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014289": {"description": "RNA polymerase sigma-24-related", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma-24-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014290": {"description": "SUF system FeS cluster assembly regulator", "go_ids": [], "go_terms": [], "name": "SUF_FeS_clus_asmbl_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014291": {"description": "SUF system FeS cluster assembly associated", "go_ids": [], "go_terms": [], "name": "SUF_FeS_clus_asmbl-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014292": {"description": "Acyltransferase, WS/DGAT/MGAT", "go_ids": ["GO:0045017", "GO:0016746"], "go_terms": ["GO:0045017:glycerolipid biosynthetic process:P", "GO:0016746:acyltransferase activity:F"], "name": "Acyl_transf_WS/DGAT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014293": {"description": "RNA polymerase sigma-70, actinobacteria", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma70_actinobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014294": {"description": "RNA polymerase sigma-W, bacillaceae", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma-W_bacilli", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014296": {"description": "RNA polymerase sigma-M, bacillaceae", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma-M_bacilli", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014297": {"description": "Dimethylsulphoxide reductase, chain B", "go_ids": [], "go_terms": [], "name": "DMSO_DmsB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014298": {"description": "ECF RNA polymerase sigma factor BldN-like", "go_ids": [], "go_terms": [], "name": "BldN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014299": {"description": "Pentapeptide MXKDX repeat protein", "go_ids": [], "go_terms": [], "name": "Penta_MxKDx", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014300": {"description": "RNA polymerase sigma-V type", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma-V", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014301": {"description": "Periplasmic protein TorT", "go_ids": [], "go_terms": [], "name": "TorT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014302": {"description": "Signal transduction histidine kinase, TMAO sensor TorS", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004673", "GO:0016020"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F", "GO:0016020:membrane:C"], "name": "Sig_transdc_His_kinase_TorS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014303": {"description": "RNA polymerase sigma-70, ECF type", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma-70_ECF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014304": {"description": "RNA polymerase sigma-Z type", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma-Z", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014305": {"description": "RNA polymerase sigma-G type, actinobacteria", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma-G_actinobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014306": {"description": "Hydroxyisourate hydrolase", "go_ids": ["GO:0006144", "GO:0033971"], "go_terms": ["GO:0006144:purine nucleobase metabolic process:P", "GO:0033971:hydroxyisourate hydrolase activity:F"], "name": "Hydroxyisourate_hydrolase", "pathway_ids": ["PWY-5691", "PWY-7849", "PWY-7394", "R-SPO-6798695", "R-CEL-975634", "R-CEL-3000171", "R-CEL-6798695"], "pathways": ["PWY-5691:t:urate conversion to allantoin I", "PWY-7849:t:urate conversion to allantoin III", "PWY-7394:t:urate conversion to allantoin II", "R-SPO-6798695:r:Neutrophil degranulation", "R-CEL-975634:r:Retinoid metabolism and transport", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR014307": {"description": "Xanthine dehydrogenase, small subunit", "go_ids": ["GO:0004854", "GO:0050660"], "go_terms": ["GO:0004854:xanthine dehydrogenase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "Xanthine_DH_ssu", "pathway_ids": ["PWY-6596", "PWY-6999", "PWY-5695", "PWY-5497", "PWY-6607", "PWY-6608", "PWY-6538", "PWY-6606", "R-MMU-9748787", "R-MMU-8851680", "R-RNO-8851680", "R-HSA-9748787", "R-HSA-74259", "R-HSA-8851680", "R-DME-74259", "R-RNO-74259", "R-GGA-421178", "R-DME-964975", "R-DME-9748787", "R-MMU-74259", "R-RNO-9748787"], "pathways": ["PWY-6596:t:adenosine nucleotides degradation I", "PWY-6999:t:theophylline degradation", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6538:t:caffeine degradation III (bacteria, via demethylation)", "PWY-6606:t:guanosine nucleotides degradation II", "R-MMU-9748787:r:Azathioprine ADME", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-DME-74259:r:Purine catabolism", "R-RNO-74259:r:Purine catabolism", "R-GGA-421178:r:Urate synthesis", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-RNO-9748787:r:Azathioprine ADME"], "type": "Domain"}, "IPR014308": {"description": "Xanthine dehydrogenase accessory protein XdhC", "go_ids": [], "go_terms": [], "name": "Xanthine_DH_XdhC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014309": {"description": "Xanthine dehydrogenase, molybdopterin binding subunit", "go_ids": ["GO:0030151"], "go_terms": ["GO:0030151:molybdenum ion binding:F"], "name": "Xanthine_DH_Mopterin-bd_su", "pathway_ids": ["R-MMU-9748787", "R-MMU-8851680", "R-GGA-421178", "R-MMU-74259"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-GGA-421178:r:Urate synthesis", "R-MMU-74259:r:Purine catabolism"], "type": "Domain"}, "IPR014310": {"description": "Signal transduction histidine kinase, phosphate regulon sensor PhoR", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004673", "GO:0016020"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F", "GO:0016020:membrane:C"], "name": "Sig_transdc_His_kinase_PhoR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014311": {"description": "Guanine deaminase", "go_ids": ["GO:0008270", "GO:0008892", "GO:0006147"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0008892:guanine deaminase activity:F", "GO:0006147:guanine catabolic process:P"], "name": "Guanine_deaminase", "pathway_ids": ["PWY-7442", "PWY-6608", "PWY-6606", "PWY-5497", "R-MMU-74259", "R-SCE-74259", "R-SPO-74259", "R-HSA-74259", "R-DME-74259", "R-RNO-74259", "R-DDI-74259"], "pathways": ["PWY-7442:t:drosopterin and aurodrosopterin biosynthesis", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "R-MMU-74259:r:Purine catabolism", "R-SCE-74259:r:Purine catabolism", "R-SPO-74259:r:Purine catabolism", "R-HSA-74259:r:Purine catabolism", "R-DME-74259:r:Purine catabolism", "R-RNO-74259:r:Purine catabolism", "R-DDI-74259:r:Purine catabolism"], "type": "Family"}, "IPR014312": {"description": "Succinate dehydrogenase, hydrophobic membrane anchor", "go_ids": ["GO:0020037", "GO:0006099", "GO:0016020"], "go_terms": ["GO:0020037:heme binding:F", "GO:0006099:tricarboxylic acid cycle:P", "GO:0016020:membrane:C"], "name": "Succ_DH_anchor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014313": {"description": "Aldehyde oxidase", "go_ids": ["GO:0016491", "GO:0046872", "GO:0051287"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0046872:metal ion binding:F", "GO:0051287:NAD binding:F"], "name": "Aldehyde_oxidase", "pathway_ids": ["PWY-8084", "R-HSA-964975", "R-MMU-964975", "R-RNO-964975"], "pathways": ["PWY-8084:t:daurichromenate biosynthesis", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate"], "type": "Family"}, "IPR014314": {"description": "Succinate dehydrogenase, cytochrome b556 subunit", "go_ids": ["GO:0009055", "GO:0006099"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0006099:tricarboxylic acid cycle:P"], "name": "Succ_DH_cytb556", "pathway_ids": ["R-HSA-611105", "R-HSA-9854311", "R-SPO-71403", "R-SSC-71403", "R-BTA-9854311", "R-MMU-9854311", "R-MMU-71403", "R-SCE-71403", "R-BTA-71403", "R-DDI-71403", "R-SSC-9854311", "R-HSA-71403"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Family"}, "IPR014315": {"description": "ABC transporter, membrane fusion protein, DevB type", "go_ids": [], "go_terms": [], "name": "ABC_heterocyst_DevB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014316": {"description": "Trimethylamine N-oxide reductase system, TorE", "go_ids": [], "go_terms": [], "name": "TMAO_TorE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014317": {"description": "Transcription activator PspF", "go_ids": [], "go_terms": [], "name": "Transcription_activator_PspF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014318": {"description": "Phage shock protein, PspG", "go_ids": [], "go_terms": [], "name": "Phageshock_PspG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014319": {"description": "Phage shock protein, PspA", "go_ids": [], "go_terms": [], "name": "Phageshock_PspA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014320": {"description": "Phage shock protein, PspC", "go_ids": [], "go_terms": [], "name": "Phageshock_PspC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014321": {"description": "Phage shock protein, PspD", "go_ids": [], "go_terms": [], "name": "Phageshock_PspD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014322": {"description": "RNA polymerase sigma-B/F/G type", "go_ids": ["GO:0003677", "GO:0003700", "GO:0006352", "GO:0006355", "GO:0016987"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006352:DNA-templated transcription initiation:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma-B/F/G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014323": {"description": "Thiosulfate sulfurtransferase PspE", "go_ids": [], "go_terms": [], "name": "PspE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014324": {"description": "ABC transporter ATP-binding subunit, DevA type", "go_ids": [], "go_terms": [], "name": "ABC_heterocyst_DevA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014325": {"description": "RNA polymerase sigma-E factor, actinobacteria", "go_ids": ["GO:0016987"], "go_terms": ["GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma-E_actinobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014326": {"description": "RNA polymerase sigma-70 factor, Planctomycetaceae", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma-70_Plancto", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014327": {"description": "RNA polymerase sigma-70, Bacteroidetes type", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma70_bacteroid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014328": {"description": "Restriction endonuclease, type II, Alw26I/Eco31I/Esp3I", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_Alw26I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014329": {"description": "M6 adenine DNA methyltransferase, Alw26I", "go_ids": [], "go_terms": [], "name": "M6_adenine_DNA_mtrans_Alw26I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014330": {"description": "RNA-binding S4-related,YaaA", "go_ids": [], "go_terms": [], "name": "RNA-bd_S4-rel_YaaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014331": {"description": "RNA polymerase sigma-70 ECF-like, Rhodopirellula baltica", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma70_ECF_RHOBA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014332": {"description": "Ectoine utilization protein EutA", "go_ids": [], "go_terms": [], "name": "Ectoine_EutA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014333": {"description": "Ectoine utilization protein EutB", "go_ids": [], "go_terms": [], "name": "Ectoine_EutB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014334": {"description": "Ectoine utilization protein EutC", "go_ids": [], "go_terms": [], "name": "Ectoine_EutC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014335": {"description": "Ectoine utilization protein EutD", "go_ids": [], "go_terms": [], "name": "Ectoine_EutD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014336": {"description": "N-alpha-acetyl diaminobutyrate deacetylase DoeB", "go_ids": [], "go_terms": [], "name": "DoeB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014337": {"description": "Ectoine/Hydroxyectoine ABC transporter, substrate-binding protein EhuB", "go_ids": ["GO:0051470", "GO:0033294"], "go_terms": ["GO:0051470:ectoine transmembrane transport:P", "GO:0033294:ectoine binding:F"], "name": "Ectoine_EhuB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014338": {"description": "Uncharacterised domain CHP02996, repeat-companion domain", "go_ids": [], "go_terms": [], "name": "CHP02996_rpt-companion-dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014339": {"description": "Regulator of ribonuclease activity A, gammaproteobacteria", "go_ids": ["GO:0008428", "GO:0051252"], "go_terms": ["GO:0008428:ribonuclease inhibitor activity:F", "GO:0051252:regulation of RNA metabolic process:P"], "name": "RraA_gpbac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014340": {"description": "Lipopolysaccharide export system protein LptA", "go_ids": ["GO:0001530", "GO:0015920", "GO:0042597"], "go_terms": ["GO:0001530:lipopolysaccharide binding:F", "GO:0015920:lipopolysaccharide transport:P", "GO:0042597:periplasmic space:C"], "name": "LptA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014341": {"description": "Ectoine/hydroxyectoine ABC transporter, permease protein EhuD", "go_ids": [], "go_terms": [], "name": "Ectoine_EhuD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014342": {"description": "Ectoine/hydroxyectoine ABC transporter, permease protein EhuC", "go_ids": [], "go_terms": [], "name": "Ectoine_EhuC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014343": {"description": "Ectoine/hydroxyectoine ABC transporter, ATP-binding protein", "go_ids": [], "go_terms": [], "name": "Ectoine_EhuA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014344": {"description": "XrtA system polysaccharide deacetylase", "go_ids": [], "go_terms": [], "name": "XrtA_polysacc_deacetyl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014345": {"description": "XrtA system polysaccharide chain length determinant", "go_ids": [], "go_terms": [], "name": "XrtA_polysacc_chain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014346": {"description": "Prenyl protease-related", "go_ids": [], "go_terms": [], "name": "Prenyl_protease-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014347": {"description": "Tautomerase/MIF superfamily", "go_ids": [], "go_terms": [], "name": "Tautomerase/MIF_sf", "pathway_ids": ["PWY-6550", "PWY-5642", "R-HSA-6798695", "R-SSC-6798695", "R-RNO-202733", "R-MMU-202733", "R-MMU-6798695", "R-HSA-8950505", "R-BTA-6798695", "R-SSC-202733", "R-XTR-6798695", "R-HSA-202733", "R-RNO-6798695", "R-BTA-202733"], "pathways": ["PWY-6550:t:carbazole degradation", "PWY-5642:t:2,4-dinitrotoluene degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-XTR-6798695:r:Neutrophil degranulation", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall"], "type": "Homologous_superfamily"}, "IPR014349": {"description": "Rieske iron-sulphur protein", "go_ids": ["GO:0051537"], "go_terms": ["GO:0051537:2 iron, 2 sulfur cluster binding:F"], "name": "Rieske_Fe-S_prot", "pathway_ids": ["R-HSA-9865881", "R-DRE-9865881", "R-GGA-9865881", "R-SCE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SPO-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-MMU-611105", "R-RNO-9865881", "R-BTA-9865881", "R-SPO-611105", "R-SCE-611105", "R-SSC-9865881", "R-BTA-611105", "R-DME-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly", "R-DRE-9865881:r:Complex III assembly", "R-GGA-9865881:r:Complex III assembly", "R-SCE-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SPO-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-9865881:r:Complex III assembly", "R-BTA-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-SSC-9865881:r:Complex III assembly", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Family"}, "IPR014352": {"description": "FERM/acyl-CoA-binding protein superfamily", "go_ids": [], "go_terms": [], "name": "FERM/acyl-CoA-bd_prot_sf", "pathway_ids": ["R-HSA-5663213", "R-HSA-8874081", "R-HSA-6802952", "R-RNO-372708", "R-RNO-9020558", "R-RNO-9009391", "R-MMU-9009391", "R-MMU-445355", "R-DDI-114608", "R-HSA-5675221", "R-RNO-111465", "R-RNO-9033241", "R-MMU-5663213", "R-MMU-9013420", "R-HSA-9662360", "R-DME-2453902", "R-RNO-77289", "R-RNO-375165", "R-DME-446353", "R-CFA-6794361", "R-CEL-182971", "R-MMU-5673001", "R-HSA-6802955", "R-HSA-77289", "R-MMU-9035034", "R-DME-9013149", "R-HSA-182971", "R-HSA-6802948", "R-MMU-399955", "R-DME-114608", "R-DME-5627123", "R-HSA-437239", "R-RNO-9013148", "R-HSA-373752", "R-SCE-77289", "R-HSA-9696264", "R-HSA-9008059", "R-DRE-9603798", "R-HSA-390247", "R-DRE-8980692", "R-MMU-5627123", "R-MMU-9696264", "R-RNO-9013420", "R-MMU-354192", "R-DDI-9013418", "R-MMU-9860927", "R-MMU-5675221", "R-DME-373752", "R-HSA-9656223", "R-MMU-5674135", "R-BTA-390918", "R-RNO-390918", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-8980692", "R-HSA-9013106", "R-DDI-9013422", "R-RNO-9860927", "R-DRE-983168", "R-RNO-8874081", "R-HSA-114608", "R-MMU-8874081", "R-BTA-6794361", "R-RNO-354192", "R-CEL-354192", "R-HSA-9013148", "R-RNO-3928662", "R-RNO-390247", "R-MMU-111465", "R-HSA-9603798", "R-HSA-9020558", "R-HSA-381038", "R-MMU-437239", "R-HSA-399719", "R-RNO-437239", "R-HSA-9696270", "R-MMU-391160", "R-DME-77289", "R-RNO-391160", "R-MMU-354194", "R-RNO-399719", "R-HSA-9634638", "R-MMU-1660499", "R-MMU-390918", "R-HSA-8866427", "R-HSA-9009391", "R-XTR-8980692", "R-HSA-111465", "R-CEL-9013420", "R-DME-6794361", "R-MMU-9696270", "R-CEL-9009391", "R-HSA-9856530", "R-MMU-9696273", "R-MMU-373752", "R-MMU-9013149", "R-HSA-9725370", "R-HSA-391160", "R-HSA-6798695", "R-MMU-182971", "R-XTR-9013106", "R-HSA-5674135", "R-MMU-9013106", "R-HSA-166016", "R-CEL-354194", "R-DME-451806", "R-CEL-77289", "R-RNO-9013149", "R-CEL-2453902", "R-CFA-77289", "R-MMU-4420097", "R-CEL-5673001", "R-HSA-3928662", "R-HSA-4420097", "R-DME-2029482", "R-DRE-77289", "R-HSA-9649948", "R-DRE-390918", "R-HSA-399955", "R-MMU-9020558", "R-MMU-9603798", "R-CEL-3928662", "R-RNO-5673001", "R-RNO-8866427", "R-RNO-432722", "R-DRE-9013106", "R-CEL-9860927", "R-DME-437239", "R-MMU-166016", "R-BTA-77289", "R-MMU-2453902", "R-HSA-8950505", "R-HSA-2029482", "R-CEL-5663213", "R-DDI-77289", "R-RNO-418885", "R-HSA-5673001", "R-HSA-390918", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-8866427", "R-MMU-77289", "R-MMU-390247", "R-HSA-9860927", "R-HSA-372708", "R-RNO-6794361", "R-RNO-983168", "R-MMU-399719", "R-RNO-4420097", "R-MMU-375165", "R-MMU-114608", "R-CEL-375165", "R-CEL-390918", "R-RNO-9603798", "R-MMU-432722", "R-MMU-9013148", "R-HSA-418885", "R-RNO-354194", "R-HSA-375165", "R-HSA-1660499", "R-RNO-2029482", "R-HSA-6794361", "R-MMU-372708", "R-RNO-5663213", "R-CEL-418885", "R-HSA-6802946", "R-HSA-9035034", "R-RNO-9013106", "R-RNO-373752", "R-BTA-373752", "R-HSA-432722", "R-DME-9013423", "R-HSA-354192", "R-HSA-9013420", "R-HSA-445355", "R-CEL-5675221", "R-HSA-9662361", "R-MMU-6794361", "R-HSA-9031525", "R-HSA-354194", "R-HSA-983168", "R-MMU-9033241", "R-MMU-2029482", "R-CEL-2029482", "R-XTR-9603798", "R-HSA-5627123", "R-CEL-4420097", "R-MMU-3928662", "R-MMU-983168", "R-HSA-9022699", "R-CEL-8874081", "R-SPO-77289", "R-HSA-9664422", "R-XTR-390918", "R-HSA-9033241", "R-HSA-9696273", "R-MMU-418885", "R-HSA-2453902"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-CFA-6794361:r:Neurexins and neuroligins", "R-CEL-182971:r:EGFR downregulation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-114608:r:Platelet degranulation", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-437239:r:Recycling pathway of L1", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-SCE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9008059:r:Interleukin-37 signaling", "R-DRE-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-354192:r:Integrin signaling", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DME-373752:r:Netrin-1 signaling", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-BTA-390918:r:Peroxisomal lipid metabolism", "R-RNO-390918:r:Peroxisomal lipid metabolism", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-6794361:r:Neurexins and neuroligins", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9020558:r:Interleukin-2 signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-437239:r:Recycling pathway of L1", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-390918:r:Peroxisomal lipid metabolism", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-XTR-8980692:r:RHOA GTPase cycle", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-9013420:r:RHOU GTPase cycle", "R-DME-6794361:r:Neurexins and neuroligins", "R-MMU-9696270:r:RND2 GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-373752:r:Netrin-1 signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-182971:r:EGFR downregulation", "R-XTR-9013106:r:RHOC GTPase cycle", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-CEL-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CFA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-DRE-390918:r:Peroxisomal lipid metabolism", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DRE-9013106:r:RHOC GTPase cycle", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-437239:r:Recycling pathway of L1", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DDI-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-MMU-114608:r:Platelet degranulation", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-CEL-390918:r:Peroxisomal lipid metabolism", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-418885:r:DCC mediated attractive signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-418885:r:DCC mediated attractive signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-373752:r:Netrin-1 signaling", "R-BTA-373752:r:Netrin-1 signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-354192:r:Integrin signaling", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-445355:r:Smooth Muscle Contraction", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-XTR-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-XTR-390918:r:Peroxisomal lipid metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Homologous_superfamily"}, "IPR014353": {"description": "Membrane-bound alcohol dehydrogenase, cytochrome c subunit", "go_ids": ["GO:0005506", "GO:0016020", "GO:0016614", "GO:0020037"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016020:membrane:C", "GO:0016614:oxidoreductase activity, acting on CH-OH group of donors:F", "GO:0020037:heme binding:F"], "name": "Membr-bd_ADH_cyt_c", "pathway_ids": ["PWY-6873"], "pathways": ["PWY-6873:t:long chain fatty acid ester synthesis (engineered)"], "type": "Family"}, "IPR014358": {"description": "Enoyl-[acyl-carrier-protein] reductase (NADH)", "go_ids": ["GO:0004318", "GO:0006633"], "go_terms": ["GO:0004318:enoyl-[acyl-carrier-protein] reductase (NADH) activity:F", 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"A-agglutinin-binding subunit Aga2", "go_ids": ["GO:0050839", "GO:0000752", "GO:0009277"], "go_terms": ["GO:0050839:cell adhesion molecule binding:F", "GO:0000752:agglutination involved in conjugation with cellular fusion:P", "GO:0009277:fungal-type cell wall:C"], "name": "Aga2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014407": {"description": "5-methylcytosine restriction system component, bacterial", "go_ids": ["GO:0009307"], "go_terms": ["GO:0009307:DNA restriction-modification system:P"], "name": "McrC_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014408": {"description": "Cyclic di-GMP phosphodiesterase CdgJ-like", "go_ids": [], "go_terms": [], "name": "CdgJ/PdeH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014409": {"description": "Signal transduction histidine kinase, hybrid-type, aerobic respiration control ArcB", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004673", "GO:0016020"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F", "GO:0016020:membrane:C"], "name": "Sig_transdc_His_kin_hyb_ArcB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014410": {"description": "Adenovirus early E1A protein", "go_ids": ["GO:0006355", "GO:0044003"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0044003:symbiont-mediated perturbation of host process:P"], "name": "Aden_E1A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014412": {"description": "Genome polyprotein, Flavivirus", "go_ids": ["GO:0004483", "GO:0004482", "GO:0017111", "GO:0016817", "GO:0004252", "GO:0003968"], "go_terms": ["GO:0004483:methyltransferase cap1 activity:F", "GO:0004482:mRNA 5'-cap (guanine-N7-)-methyltransferase activity:F", "GO:0017111:ribonucleoside triphosphate phosphatase activity:F", "GO:0016817:hydrolase activity, acting on acid anhydrides:F", "GO:0004252:serine-type endopeptidase activity:F", "GO:0003968:RNA-directed RNA polymerase activity:F"], "name": "Gen_Poly_FLV", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Family"}, "IPR014413": {"description": "M polyprotein precursor, Orthobunyavirus type", "go_ids": [], "go_terms": [], "name": "M_poly_OrthobunV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014414": {"description": "Envelope glycoprotein precursor/M polyprotein precursor, Tospovirus type", "go_ids": [], "go_terms": [], "name": "M_poly_TospoV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014416": {"description": "DNA-directed DNA polymerase, family B, phi29-like virus", "go_ids": ["GO:0001882", "GO:0003887", "GO:0039693"], "go_terms": ["GO:0001882:nucleoside binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0039693:viral DNA genome replication:P"], "name": "DNA-dir_DNA_polB_phi29_vir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014417": {"description": "Integrase, predicted", "go_ids": [], "go_terms": [], "name": "Integrase_predicted", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014418": {"description": "Putative type 4B encapsulin shell protein", "go_ids": [], "go_terms": [], "name": "ENCP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014419": {"description": "Heme utilization protein HutZ", "go_ids": [], "go_terms": [], "name": "HutZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014422": {"description": "Cobalamin (vitamin B12) biosynthesis, bifunctional CbiH/CbiC", "go_ids": ["GO:0009236"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P"], "name": "Cbl_synth_bifunc_CbiH/CbiC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014424": {"description": "Uncharacterised conserved protein UCP004897, ACT- type", "go_ids": [], "go_terms": [], "name": "UCP004897_ACT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014426": {"description": "Uncharacterised protein family UPF0282, hydrolase, metallo-beta-lactamase", "go_ids": [], "go_terms": [], "name": "UPF0282_hydrls", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014428": {"description": "Crossover junction endodeoxyribonuclease Hjc, archaeal", "go_ids": [], "go_terms": [], "name": "Hjc_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014430": {"description": "Sterol desaturase Scs7", "go_ids": ["GO:0006629", "GO:0080132", "GO:0016020"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0080132:fatty acid 2-hydroxylase activity:F", "GO:0016020:membrane:C"], "name": "Scs7", "pathway_ids": ["PWY-6014", "PWY-8191", "PWY-7154", "PWY-6409", "PWY-6710", "R-RNO-1660661", "R-HSA-1660661", "R-MMU-1660661"], "pathways": ["PWY-6014:t:vernolate biosynthesis I", "PWY-8191:t:cholesterol biosynthesis (algae, late side-chain reductase)", "PWY-7154:t:ergosterol biosynthesis II", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-6710:t:poly-hydroxy fatty acids biosynthesis", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR014431": {"description": "Tellurite resistance methyltransferase, TehB type-2", "go_ids": [], "go_terms": [], "name": "Tellurite-R_TehB-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014433": {"description": "Carbon monoxide dehydrogenase accessory protein CooC", "go_ids": [], "go_terms": [], "name": "CooC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014434": {"description": "Monothiol glutaredoxin", "go_ids": ["GO:0015036"], "go_terms": ["GO:0015036:disulfide oxidoreductase activity:F"], "name": "Monothiol_GRX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014435": {"description": "N(4)-bis(aminopropyl)spermidine synthase", "go_ids": ["GO:0006596", "GO:0016765"], "go_terms": ["GO:0006596:polyamine biosynthetic process:P", "GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "BpsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014436": {"description": "Extradiol aromatic ring-opening dioxygenase, DODA-type", "go_ids": ["GO:0008270", "GO:0051213"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0051213:dioxygenase activity:F"], "name": "Extradiol_dOase_DODA", "pathway_ids": ["PWY-5394"], "pathways": ["PWY-5394:t:betalamic acid biosynthesis"], "type": "Family"}, "IPR014438": {"description": "Glucan biosynthesis protein MdoG/MdoD", "go_ids": [], "go_terms": [], "name": "Glucan_biosyn_MdoG/MdoD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014440": {"description": "HCCA isomerase/glutathione S-transferase kappa", "go_ids": [], "go_terms": [], "name": "HCCAis_GSTk", "pathway_ids": ["PWY-6842", "PWY-7533", "PWY-7112", "PWY-4061", "R-RNO-9033241", "R-RNO-156590", "R-MMU-9033241", "R-CEL-156590", "R-HSA-156590", "R-HSA-9033241", "R-MMU-156590"], "pathways": ["PWY-6842:t:glutathione-mediated detoxification II", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7112:t:4-hydroxy-2-nonenal detoxification", "PWY-4061:t:glutathione-mediated detoxification I", "R-RNO-9033241:r:Peroxisomal protein import", "R-RNO-156590:r:Glutathione conjugation", "R-MMU-9033241:r:Peroxisomal protein import", "R-CEL-156590:r:Glutathione conjugation", "R-HSA-156590:r:Glutathione conjugation", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-156590:r:Glutathione conjugation"], "type": "Family"}, "IPR014441": {"description": "Uncharacterised conserved protein UCP006425, beta-propeller-type", "go_ids": [], "go_terms": [], "name": "UCP006425_b-propeller", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014444": {"description": "Damage-control phosphatase PH1575-like", "go_ids": [], "go_terms": [], "name": "PH1575-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014445": {"description": "Glutamine-dependent NAD(+) synthetase", "go_ids": ["GO:0003952", "GO:0005524", "GO:0009435"], "go_terms": ["GO:0003952:NAD+ synthase (glutamine-hydrolyzing) activity:F", "GO:0005524:ATP binding:F", "GO:0009435:NAD+ biosynthetic process:P"], "name": "Gln-dep_NAD_synthase", "pathway_ids": ["PWY-8277", "PWY-5653", "PWY-5381", "PWY-8352", "PWY-7761", "R-SPO-196807", "R-MMU-196807", "R-HSA-196807", "R-BTA-196807", "R-DDI-196807", "R-DME-196807", "R-RNO-196807", "R-SCE-196807"], "pathways": ["PWY-8277:t:NAD de novo biosynthesis IV (anaerobic)", "PWY-5653:t:NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde", "PWY-5381:t:NAD salvage (plants)", "PWY-8352:t:NAD de novo biosynthesis III", "PWY-7761:t:NAD salvage pathway II (PNC IV cycle)", "R-SPO-196807:r:Nicotinate metabolism", "R-MMU-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-BTA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-DME-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-SCE-196807:r:Nicotinate metabolism"], "type": "Family"}, "IPR014447": {"description": "Antitoxin VapB-like, probable", "go_ids": [], "go_terms": [], "name": "VapB-like_prob", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014448": {"description": "Anti-adapter protein IraM", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "Anti-adapter_IraM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014449": {"description": "Uncharacterised conserved protein UCP007050, HI0931", "go_ids": [], "go_terms": [], "name": "UCP007050_HI0931", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014450": {"description": "Uncharacterised conserved protein UCP008210", "go_ids": [], "go_terms": [], "name": "UCP008210", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014451": {"description": "Uncharacterised conserved protein UCP008455", "go_ids": [], "go_terms": [], "name": "UCP008455", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014453": {"description": "Inhibitor of vertebrate lysozyme", "go_ids": ["GO:0042597", "GO:0043086"], "go_terms": ["GO:0042597:periplasmic space:C", "GO:0043086:negative regulation of catalytic activity:P"], "name": "Inhibitor_vertebrate_lysozyme", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014455": {"description": "DNA methylase, N-6 adenine-specific, MK1259 type", "go_ids": [], "go_terms": [], "name": "N6_adenine_Mtase_MK1259", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014456": {"description": "Uncharacterised conserved protein UCP010244, integral membrane protein", "go_ids": [], "go_terms": [], "name": "UCP010244_IM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014457": {"description": "Uncharacterised conserved protein UCP010260", "go_ids": [], "go_terms": [], "name": "UCP010260", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014458": {"description": "Uncharacterised protein family, phage P2-GpU-fusion", "go_ids": [], "go_terms": [], "name": "Unchr_Phage_P2-GpU-fusion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014459": {"description": "Transcriptional activator VP30, Filoviridae type", "go_ids": ["GO:0003723", "GO:0008270"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0008270:zinc ion binding:F"], "name": "VP30_FiloV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014460": {"description": "Signal transduction response regulator, predicted, VieB", "go_ids": [], "go_terms": [], "name": "Sig_transdc_resp-reg_VieB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014461": {"description": "Vacuolar protein sorting-associated protein 17, Vps17", "go_ids": ["GO:0030904", "GO:0042147", "GO:0015031"], "go_terms": ["GO:0030904:retromer complex:C", "GO:0042147:retrograde transport, endosome to Golgi:P", "GO:0015031:protein transport:P"], "name": "Retromer_complex_Vps17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014462": {"description": "Phage-associated protein Gp45", "go_ids": [], "go_terms": [], "name": "Phage_Mu_Gp45", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014464": {"description": "Conserved virulence factor B", "go_ids": [], "go_terms": [], "name": "CvfB_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014465": {"description": "Uncharacterised conserved protein UCP012622", "go_ids": [], "go_terms": [], "name": "UCP012622", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014466": {"description": "Predicted transcriptional regulator, AF1742 type", "go_ids": [], "go_terms": [], "name": "Txn_rg_UCP012876", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014468": {"description": "Uncharacterised conserved protein UCP014979", "go_ids": [], "go_terms": [], "name": "UCP014979", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014469": {"description": "Protein of unknown function DUF2271", "go_ids": [], "go_terms": [], "name": "DUF2271", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014470": {"description": "Uncharacterised conserved protein UCP01500", "go_ids": [], "go_terms": [], "name": "UCP01500", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014472": {"description": "Choline/ethanolamine phosphotransferase", "go_ids": [], "go_terms": [], "name": "CHOPT", "pathway_ids": ["PWY-7782", "PWY-7618", "PWY-8053", "PWY-6804", "PWY-3561", "PWY-8051", "PWY-8055", "R-HSA-1483191", "R-HSA-1483213", "R-BTA-1483213", "R-SCE-1483213", "R-RNO-1483213", "R-DDI-1483191", "R-RNO-1483191", "R-DRE-1483191", "R-SPO-1483213", "R-MMU-1483191", "R-SCE-1483191", "R-BTA-1483191", "R-GGA-1483191", "R-MMU-1483213", "R-SPO-1483191", "R-DDI-1483213"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7618:t:ricinoleate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6804:t:diacylglycerol biosynthesis (PUFA enrichment in oilseed)", "PWY-3561:t:choline biosynthesis III", "PWY-8051:t:anandamide biosynthesis I", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "R-HSA-1483191:r:Synthesis of PC", "R-HSA-1483213:r:Synthesis of PE", "R-BTA-1483213:r:Synthesis of PE", "R-SCE-1483213:r:Synthesis of PE", "R-RNO-1483213:r:Synthesis of PE", "R-DDI-1483191:r:Synthesis of PC", "R-RNO-1483191:r:Synthesis of PC", "R-DRE-1483191:r:Synthesis of PC", "R-SPO-1483213:r:Synthesis of PE", "R-MMU-1483191:r:Synthesis of PC", "R-SCE-1483191:r:Synthesis of PC", "R-BTA-1483191:r:Synthesis of PC", "R-GGA-1483191:r:Synthesis of PC", "R-MMU-1483213:r:Synthesis of PE", "R-SPO-1483191:r:Synthesis of PC", "R-DDI-1483213:r:Synthesis of PE"], "type": "Family"}, "IPR014476": {"description": "AT-hook motif nuclear-localized protein 15-29", "go_ids": ["GO:0003680"], "go_terms": ["GO:0003680:minor groove of adenine-thymine-rich DNA binding:F"], "name": "AHL15-29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014478": {"description": "Putative membrane protein, NMB1733 type", "go_ids": [], "go_terms": [], "name": "UCP016195", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014480": {"description": "Mannan endo-1,6-alpha-mannosidase", "go_ids": ["GO:0008496", "GO:0016052"], "go_terms": ["GO:0008496:mannan endo-1,6-alpha-mannosidase activity:F", "GO:0016052:carbohydrate catabolic process:P"], "name": "Mannan-1_6-alpha_mannosidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014481": {"description": "Uncharacterised conserved protein UCP016662, toprim-type", "go_ids": [], "go_terms": [], "name": "UCP016662_toprim", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014483": {"description": "Fis-like DNA-binding domain-containing signal transduction response regulator, predicted", "go_ids": [], "go_terms": [], "name": "Sig_transdc_resp-reg_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014484": {"description": "Uncharacterised conserved protein UCP016792", "go_ids": [], "go_terms": [], "name": "UCP016792", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014485": {"description": "5'-nucleotidase SMN1-like", "go_ids": [], "go_terms": [], "name": "SMN1-like", "pathway_ids": ["PWY-7821", "PWY-7185", "PWY-5381", "PWY-6596", "PWY-5695", "PWY-6607", "PWY-6608", "PWY-6606"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-5381:t:NAD salvage (plants)", "PWY-6596:t:adenosine nucleotides degradation I", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II"], "type": "Family"}, "IPR014487": {"description": "Protein of unknown function DUF3151", "go_ids": [], "go_terms": [], "name": "DUF3151", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014488": {"description": "Uncharacterised conserved protein UCP017371", "go_ids": [], "go_terms": [], "name": "UCP017371", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014490": {"description": "DNA-binding protein from starved cells-like", "go_ids": [], "go_terms": [], "name": "Dps-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014491": {"description": "Curli production protein CsgC", "go_ids": [], "go_terms": [], "name": "Curli_production_prot_CsgC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014492": {"description": "Poly(A) polymerase", "go_ids": ["GO:1990817", "GO:0005634"], "go_terms": ["GO:1990817:poly(A) RNA polymerase activity:F", "GO:0005634:nucleus:C"], "name": "PolyA_polymerase", "pathway_ids": ["R-HSA-77595", "R-SPO-9770562", "R-MMU-72187", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-77595", "R-BTA-73856", "R-BTA-9770562", "R-HSA-73856", "R-MMU-73856", "R-HSA-72187", "R-SPO-9930044", "R-HSA-9918481", "R-BTA-77595"], "pathways": ["R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Family"}, "IPR014494": {"description": "Predicted Fe-S oxidoreductase, NifB/MoaA-like family, euryarchaeota type", "go_ids": [], "go_terms": [], "name": "Fe-S_OxRdtase_NifB-like_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014495": {"description": "Uncharacterised conserved protein UCP018671", "go_ids": [], "go_terms": [], "name": "UCP018671", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014496": {"description": "Uncharacterised conserved protein UCP018863", "go_ids": [], "go_terms": [], "name": "UCP018863", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014497": {"description": "Methylmalonyl-CoA decarboxylase, delta subunit", "go_ids": [], "go_terms": [], "name": "MeMalonyl-CoA_deCOase_dsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014499": {"description": "Diadenylate cyclase, DacZ-type", "go_ids": [], "go_terms": [], "name": "DAC_DacZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014500": {"description": "Uncharacterised conserved protein UCP019307, cupin-type", "go_ids": [], "go_terms": [], "name": "UCP019307_cupin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014501": {"description": "Uncharacterised conserved protein UCP019317", "go_ids": [], "go_terms": [], "name": "UCP019317", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014503": {"description": "Clavaminate synthase-like", "go_ids": ["GO:0005506", "GO:0016491"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "Clavaminate_syn-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014505": {"description": "UMP-CMP kinase 2, mitochondrial", "go_ids": ["GO:0050145"], "go_terms": ["GO:0050145:nucleoside monophosphate kinase activity:F"], "name": "UMP-CMP_kinase_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014506": {"description": "Uncharacterised conserved protein UCP020479, signal transduction CheW-like", "go_ids": [], "go_terms": [], "name": "UCP020479_CheW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014507": {"description": "Baseplate assembly protein J, predicted", "go_ids": [], "go_terms": [], "name": "Baseplate_assembly_J_pred", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014508": {"description": "Uncharacterised conserved protein withTPR-like repeats", "go_ids": [], "go_terms": [], "name": "UCP020555_TPR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014509": {"description": "Inner membrane protein YjdF-like", "go_ids": [], "go_terms": [], "name": "YjdF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014510": {"description": "Tellurite resistance predicted, YeaR", "go_ids": [], "go_terms": [], "name": "Tellurite-R_YeaR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014511": {"description": "Protein of unknown function DUF2068, transmembrane, subgroup", "go_ids": [], "go_terms": [], "name": "DUF2068_TM_subgr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014512": {"description": "Predicted O-glycosyl hydrolase", "go_ids": [], "go_terms": [], "name": "O_gly_hydro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014513": {"description": "Uncharacterised conserved protein UCP021525", "go_ids": [], "go_terms": [], "name": "UCP021525", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014514": {"description": "Uncharacterised conserved protein UCP021940", "go_ids": [], "go_terms": [], "name": "UCP021940", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014515": {"description": "Uncharacterised conserved protein UCP921964", "go_ids": [], "go_terms": [], "name": "UCP921964", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014517": {"description": "ArsR transcriptional regulator", "go_ids": [], "go_terms": [], "name": "ArsR_tscrpt_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014518": {"description": "Uncharacterised conserved protein UCP022079", "go_ids": [], "go_terms": [], "name": "UCP022079", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014519": {"description": "Uncharacterised conserved protein UCP024492", "go_ids": [], "go_terms": [], "name": "UCP024492", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014522": {"description": "Archaeosortase A", "go_ids": [], "go_terms": [], "name": "ArtA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014524": {"description": "Outer membrane protein assembly factor BamC", "go_ids": [], "go_terms": [], "name": "BamC", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR014525": {"description": "Ethylene receptor", "go_ids": ["GO:0005789", "GO:0038199", "GO:0051740", "GO:0009723", "GO:0004672"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0038199:ethylene receptor activity:F", "GO:0051740:ethylene binding:F", "GO:0009723:response to ethylene:P", "GO:0004672:protein kinase activity:F"], "name": "ETR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014527": {"description": "Excinuclease GIY-YIG catalytic domain-containing uncharacterised conserved protein", "go_ids": [], "go_terms": [], "name": "UCP026568_excinuclease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014528": {"description": "Cyclic-di-AMP phosphodiesterase GdpP/PdeA", "go_ids": [], "go_terms": [], "name": "GdpP/PdeA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014529": {"description": "Uncharacterised conserved protein UCP026631", "go_ids": [], "go_terms": [], "name": "UCP026631", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014535": {"description": "Predicted heptaprenyl diphosphate synthase, component I", "go_ids": [], "go_terms": [], "name": "Hpre_diP_synt_I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014536": {"description": "Sorting nexin 9 family", "go_ids": ["GO:0000278", "GO:0015031"], "go_terms": ["GO:0000278:mitotic cell cycle:P", "GO:0015031:protein transport:P"], "name": "Snx9_fam", "pathway_ids": ["R-CEL-8856828", "R-CEL-432722", "R-MMU-8856828", "R-HSA-432722", "R-HSA-8856828", "R-MMU-432722"], "pathways": ["R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR014537": {"description": "Uncharacterised conserved protein UCP027893", "go_ids": [], "go_terms": [], "name": "UCP027893", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014538": {"description": "Uncharacterised conserved protein, topoisomerase zinc finger", "go_ids": [], "go_terms": [], "name": "UCP028063_topo_Znf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014540": {"description": "Uncharacterised conserved protein UCP028175", "go_ids": [], "go_terms": [], "name": "UCP028175", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014541": {"description": "Predicted amidinotransferase, FN0238 type", "go_ids": [], "go_terms": [], "name": "Amdntrnsf_FN0238", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014543": {"description": "Uncharacterised conserved protein UCP028291", "go_ids": [], "go_terms": [], "name": "UCP028291", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014544": {"description": "Uncharacterised conserved protein UCP028408", "go_ids": [], "go_terms": [], "name": "UCP028408", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014545": {"description": "Uncharacterised conserved protein UCP028415", "go_ids": [], "go_terms": [], "name": "UCP028415", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014546": {"description": "Uncharacterised conserved protein, lipid A biosynthesis", "go_ids": [], "go_terms": [], "name": "UCP028440_lipidA_biosyn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014547": {"description": "Uncharacterised conserved protein UCP028477", "go_ids": [], "go_terms": [], "name": "UCP028477", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014548": {"description": "Predicted acyltransferase", "go_ids": [], "go_terms": [], "name": "Ac_Trasf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014549": {"description": "Flagellar protein FlgO", "go_ids": [], "go_terms": [], "name": "FlgO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014550": {"description": "Uncharacterised conserved protein UCP028704, OpgC", "go_ids": [], "go_terms": [], "name": "UCP028704_OpgC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014551": {"description": "Beta-glucosidase GBA2-type", "go_ids": ["GO:0004348", "GO:0006680", "GO:0016020"], "go_terms": ["GO:0004348:glucosylceramidase activity:F", "GO:0006680:glucosylceramide catabolic process:P", "GO:0016020:membrane:C"], "name": "B_Glucosidase_GBA2-typ", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-6848", "PWY-7487", "PWY-6655", "PWY-7940", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-8436", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-5976", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7057", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-7529", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-7091", "PWY-1901", "PWY-8241", "PWY-7745", "PWY-7055", "PWY-6527", "PWY-5139", "PWY-7143", "PWY-7647", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-6821", "PWY-5339", "PWY-6735", "PWY-5310", "PWY-6855", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-862", "PWY-6737", "PWY-7445", "PWY-5821", "PWY-8379", "PWY-6749", "PWY-7463", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-7134", "PWY-7133", "PWY-1921", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-6784", "PWY-7838", "PWY-7960", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-6717", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-6906", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-8435", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-7074", "PWY-8272", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8366", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-842", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-7056", "PWY-7256", "PWY-5400", "PWY-7697", "R-MMU-9840310", "R-RNO-9840310", "R-HSA-9840310", "R-DME-9840310"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-6848:t:rutin degradation", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-8436:t:mammalian high-mannose N-glycan degradation", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-5976:t:dhurrin degradation", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7057:t:cichoriin interconversion", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-7091:t:linustatin bioactivation", "PWY-1901:t:aurone biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-6527:t:stachyose degradation", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-7647:t:ulvan degradation", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-6821:t:kappa-carrageenan degradation", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-6735:t:starch degradation IV", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-6855:t:chitin degradation I (archaea)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-862:t:fructan degradation", "PWY-6737:t:starch degradation V", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-5821:t:dalcochinin biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7134:t:rutin degradation (plants)", "PWY-7133:t:quercetin glucoside degradation (Allium)", "PWY-1921:t:indole-3-acetate activation II", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-7960:t:rhabduscin biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-6717:t:(1,4)-beta-D-xylan degradation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-6906:t:chitin derivatives degradation", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-8435:t:yeast mannan degradation", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-842:t:starch degradation I", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7056:t:daphnin interconversion", "PWY-7256:t:cyanidin diglucoside biosynthesis (acyl-glucose dependent)", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-DME-9840310:r:Glycosphingolipid catabolism"], "type": "Family"}, "IPR014553": {"description": "Predicted aminopeptidase", "go_ids": [], "go_terms": [], "name": "Aminopept", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014555": {"description": "RecF-like", "go_ids": [], "go_terms": [], "name": "RecF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014556": {"description": "Uncharacterised conserved protein UCP029407", "go_ids": [], "go_terms": [], "name": "UCP029407", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014557": {"description": "Uncharacterised conserved protein UCP029548, STAS-type", "go_ids": [], "go_terms": [], "name": "UCP029548_STAS-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014558": {"description": "Uncharacterised conserved lipoprotein", "go_ids": [], "go_terms": [], "name": "UCP029720", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014560": {"description": "Uncharacterised conserved protein UCP030333, DNA/RNA-binding Alba-related", "go_ids": [], "go_terms": [], "name": "UCP030333_Alba", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014562": {"description": "Uncharacterised conserved protein UCP030959, divergent TPR repeat-containing", "go_ids": [], "go_terms": [], "name": "UCP030959_TPR_rpt-cont", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014564": {"description": "Uncharacterised conserved protein UCP031503, transmembrane", "go_ids": [], "go_terms": [], "name": "UCP031503_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014565": {"description": "Phosphodiester glycosidase-like", "go_ids": [], "go_terms": [], "name": "PDG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014567": {"description": "Uncharacterised conserved protein UCP031900", "go_ids": [], "go_terms": [], "name": "UCP031900", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014569": {"description": "Ubiquinol-cytochrome c chaperone, CBP3-related", "go_ids": [], "go_terms": [], "name": "Ubq_cyt-c_CBP3-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014570": {"description": "Encapsidation protein CP3", "go_ids": [], "go_terms": [], "name": "Encapsidation_CP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014571": {"description": "Uncharacterised conserved protein UCP032620", "go_ids": [], "go_terms": [], "name": "UCP032620", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014572": {"description": "Uncharacterised conserved protein UCP032673", "go_ids": [], "go_terms": [], "name": "UCP032673", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014573": {"description": "Uncharacterised conserved protein UCP032806", "go_ids": [], "go_terms": [], "name": "UCP032806", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014574": {"description": "Uncharacterised conserved protein UCP032908", "go_ids": [], "go_terms": [], "name": "UCP032908", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014575": {"description": "Type III secretion system, secreted protein EspD", "go_ids": [], "go_terms": [], "name": "T3SS_EspD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014576": {"description": "Predicted phosphoesterase, YhaO type", "go_ids": [], "go_terms": [], "name": "Pesterase_YhaO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014577": {"description": "Uncharacterised conserved protein UCP033093, metallophosphoesterase-type", "go_ids": [], "go_terms": [], "name": "UCP033093_metalloPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014578": {"description": "Predicted phosphoesterase, CT488 type", "go_ids": [], "go_terms": [], "name": "Pesterase_CT488", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014579": {"description": "Predicted 5'-nucleotidase, SA0022 type", "go_ids": [], "go_terms": [], "name": "5NTD_SA0022", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014580": {"description": "Uncharacterised conserved protein UCP033199", "go_ids": [], "go_terms": [], "name": "UCP033199", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014581": {"description": "Uncharacterised conserved protein UCP033303", "go_ids": [], "go_terms": [], "name": "UCP033303", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014582": {"description": "Uncharacterised conserved protein UCP033535, periplasmic lipoprotein", "go_ids": [], "go_terms": [], "name": "UCP033535_lipo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014583": {"description": "Uncharacterised protein family, Sir2-like", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Sir2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014584": {"description": "Uncharacterised conserved protein UCP033729", "go_ids": [], "go_terms": [], "name": "UCP033729", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014586": {"description": "Uncharacterised conserved protein UCP033909", "go_ids": [], "go_terms": [], "name": "UCP033909", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014587": {"description": "Uncharacterised conserved protein UCP034077", "go_ids": [], "go_terms": [], "name": "UCP034077", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014588": {"description": "ATPase, Atu1862 type, predicted", "go_ids": [], "go_terms": [], "name": "ATPase_Atu1862_pred", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014590": {"description": "Uncharacterised conserved protein MORN repeat-containing", "go_ids": [], "go_terms": [], "name": "UCP034300_MORN_rpt-cont", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014591": {"description": "Uncharacterised conserved protein UCP034455", "go_ids": [], "go_terms": [], "name": "UCP034455", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014592": {"description": "Predicted P-loop ATP-binding protein, VCA0200", "go_ids": [], "go_terms": [], "name": "P-loop_UCP034888", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014593": {"description": "Uncharacterised conserved protein UCP034961, SH3-2", "go_ids": [], "go_terms": [], "name": "UCP034961_SH3_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014596": {"description": "Uncharacterised conserved protein UCP035836", "go_ids": [], "go_terms": [], "name": "UCP035836", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014597": {"description": "ABC transporter, periplasmic substrate-binding protein, predicted", "go_ids": ["GO:0022857"], "go_terms": ["GO:0022857:transmembrane transporter activity:F"], "name": "ABC_tp_sb", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014598": {"description": "SpbR", "go_ids": [], "go_terms": [], "name": "SpbR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014600": {"description": "Uncharacterised conserved protein UCP035905, membrane protein", "go_ids": [], "go_terms": [], "name": "UCP035905_mem", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014601": {"description": "Transcriptional regulator with MarR-type HTH domain", "go_ids": [], "go_terms": [], "name": "Trans_reg_MarR_HTH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014602": {"description": "Uncharacterised conserved protein UCP036226", "go_ids": [], "go_terms": [], "name": "UCP036226", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014603": {"description": "Formate dehydrogenase iron-sulphur subunit", "go_ids": ["GO:0015944", "GO:0045333", "GO:0051539"], "go_terms": ["GO:0015944:formate oxidation:P", "GO:0045333:cellular respiration:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Formate_DH_Fe-S_su", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014605": {"description": "Signal transduction response regulator PhyR-like, alphaproteobacteria", "go_ids": [], "go_terms": [], "name": "Sig_resp-reg_PhyR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014606": {"description": "D,D-heptose 7-phosphate kinase", "go_ids": [], "go_terms": [], "name": "Heptose_7-P_kinase", "pathway_ids": ["PWY-6478"], "pathways": ["PWY-6478:t:GDP-D-glycero-alpha-D-manno-heptose biosynthesis"], "type": "Family"}, "IPR014607": {"description": "Alkane 1-monooxygenase, rubredoxin-type", "go_ids": [], "go_terms": [], "name": "Alk_mOase_rubredoxin-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014608": {"description": "ATP-citrate synthase", "go_ids": ["GO:0003878", "GO:0006085", "GO:0006101"], "go_terms": ["GO:0003878:ATP citrate synthase activity:F", "GO:0006085:acetyl-CoA biosynthetic process:P", "GO:0006101:citrate metabolic process:P"], "name": "ATP-citrate_synthase", "pathway_ids": ["PWY-5172", "R-HSA-163765", "R-HSA-6798695", "R-BTA-75105", "R-HSA-75105", "R-CEL-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-RNO-75105", "R-MMU-75105", "R-RNO-6798695", "R-CEL-75105"], "pathways": ["PWY-5172:t:acetyl-CoA biosynthesis from citrate", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Family"}, "IPR014610": {"description": "Globin, extracellular", "go_ids": ["GO:0005506", "GO:0005576", "GO:0005833", "GO:0015671", "GO:0019825", "GO:0020037"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0005576:extracellular region:C", "GO:0005833:hemoglobin complex:C", "GO:0015671:oxygen transport:P", "GO:0019825:oxygen binding:F", "GO:0020037:heme binding:F"], "name": "Haemoglobin_extracell", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014612": {"description": "Ribonucleases P/MRP protein subunit Rpp20/Pop7", "go_ids": ["GO:0000172", "GO:0005655", "GO:0001682", "GO:0006396"], "go_terms": ["GO:0000172:ribonuclease MRP complex:C", "GO:0005655:nucleolar ribonuclease P complex:C", "GO:0001682:tRNA 5'-leader removal:P", "GO:0006396:RNA processing:P"], "name": "Pop7/Rpp20", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR014614": {"description": "KsdD-like steroid dehydrogenase", "go_ids": ["GO:0016627"], "go_terms": ["GO:0016627:oxidoreductase activity, acting on the CH-CH group of donors:F"], "name": "KsdD_DH", "pathway_ids": ["PWY-6944", "PWY-6945", "PWY-8152", "PWY-6948", "PWY-7552", "PWY-6672", "PWY-8155", "PWY-6061", "PWY-6279", "PWY-8151", "PWY-6946", "PWY-7636"], "pathways": ["PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7552:t:heme b biosynthesis III (from siroheme)", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-8155:t:testosterone degradation (anaerobic)", "PWY-6061:t:bile acid biosynthesis, neutral pathway", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7636:t:astaxanthin biosynthesis (flowering plants)"], "type": "Family"}, "IPR014615": {"description": "Extracellular sulfatase", "go_ids": ["GO:0005509", "GO:0005783", "GO:0005794", "GO:0008484", "GO:0009986"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0005783:endoplasmic reticulum:C", "GO:0005794:Golgi apparatus:C", "GO:0008484:sulfuric ester hydrolase activity:F", "GO:0009986:cell surface:C"], "name": "Extracellular_sulfatase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014617": {"description": "Predicted membrane protein, Bacillus YphA type", "go_ids": [], "go_terms": [], "name": "YphA_Bacsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014619": {"description": "Deoxycytidylate hydroxymethylase", "go_ids": ["GO:0047153"], "go_terms": ["GO:0047153:deoxycytidylate 5-hydroxymethyltransferase activity:F"], "name": "Deoxycytidylate_hydroxyMease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014620": {"description": "Thymidylate synthase, archaea", "go_ids": ["GO:0004799", "GO:0005737", "GO:0006235"], "go_terms": ["GO:0004799:thymidylate synthase activity:F", "GO:0005737:cytoplasm:C", "GO:0006235:dTTP biosynthetic process:P"], "name": "Thymidylate_synthase_arc", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR014621": {"description": "Uncharacterised conserved protein UCP036778, sugar epimerase-type", "go_ids": [], "go_terms": [], "name": "UCP036778_sugar_epimerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014622": {"description": "Uncharacterised conserved protein UCP036794, erythromycin esterase-type", "go_ids": [], "go_terms": [], "name": "UCP036794_erythomycin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014623": {"description": "Transcription factor TFIIIC subunit Tfc7/tau55", "go_ids": [], "go_terms": [], "name": "Tfc7/tau55", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014624": {"description": "Predicted 26S proteasome regulatory complex, non-ATPase subcomplex, subunit s5a, Plasmodium", "go_ids": [], "go_terms": [], "name": "26S_protsm_s5a", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014625": {"description": "Filoviruses glycoprotein", "go_ids": [], "go_terms": [], "name": "GPC_FiloV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014626": {"description": "Signal transduction response regulator with modified HD-GYP domain, putative", "go_ids": [], "go_terms": [], "name": "Sig_transdc_resp-reg_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014627": {"description": "Uncharacterised conserved protein UCP036888, signal transduction HD-GYP-like, PA5346 type", "go_ids": [], "go_terms": [], "name": "UCP036888_HDGYP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014628": {"description": "Mannose-6-phosphate isomerase, Firmicutes type, short form", "go_ids": ["GO:0004476", "GO:0005975"], "go_terms": ["GO:0004476:mannose-6-phosphate isomerase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "Man6P_isomerase_Firm_short", "pathway_ids": ["PWY-5659", "PWY-3861", "PWY-6992", "PWY-7586", "PWY-3881", "PWY-7456"], "pathways": ["PWY-5659:t:GDP-mannose biosynthesis", "PWY-3861:t:mannitol degradation II", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7586:t:beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation", "PWY-3881:t:mannitol biosynthesis", "PWY-7456:t:beta-(1,4)-mannan degradation"], "type": "Family"}, "IPR014631": {"description": "Cellular repressor of E1A-stimulated genes (CREG)", "go_ids": [], "go_terms": [], "name": "CREG", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR014635": {"description": "Alpha-amylase, MalS type", "go_ids": ["GO:0009313", "GO:0030980", "GO:0004556", "GO:0005509", "GO:0042597"], "go_terms": ["GO:0009313:oligosaccharide catabolic process:P", "GO:0030980:alpha-glucan catabolic process:P", "GO:0004556:alpha-amylase activity:F", "GO:0005509:calcium ion binding:F", "GO:0042597:periplasmic space:C"], "name": "A_amylase_MalS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014636": {"description": "RNase H, phosphoglycerate mutase domain-containing", "go_ids": [], "go_terms": [], "name": "RNaseH/PGlycerate_mutase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014637": {"description": "Sorting nexin-5/6/32", "go_ids": [], "go_terms": [], "name": "SNX5/SNX6/SNX32", "pathway_ids": ["R-BTA-432722", "R-HSA-432722", "R-RNO-432722", "R-MMU-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR014638": {"description": "Double C2 protein, alpha/beta/gamma", "go_ids": [], "go_terms": [], "name": "Doc2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014640": {"description": "Imidazole glycerol phosphate synthase HisHF", "go_ids": ["GO:0004359", "GO:0000105", "GO:0000107"], "go_terms": ["GO:0004359:glutaminase activity:F", "GO:0000105:L-histidine biosynthetic process:P", "GO:0000107:imidazoleglycerol-phosphate synthase activity:F"], "name": "IGPS_HisHF", "pathway_ids": ["PWY-5921"], "pathways": ["PWY-5921:t:glutaminyl-tRNAgln biosynthesis via transamidation"], "type": "Family"}, "IPR014644": {"description": "Protein arginine N-methyltransferase PRMT7", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "MeTrfase_PRMT7", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-CEL-3214858", "R-DRE-3214858", "R-HSA-3214858", "R-MMU-3214858", "R-RNO-3214858"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-RNO-3214858:r:RMTs methylate histone arginines"], "type": "Family"}, "IPR014645": {"description": "Target of Myb protein 1", "go_ids": [], "go_terms": [], "name": "TOM1", "pathway_ids": ["R-MMU-6798695", "R-GGA-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR014646": {"description": "Replication factor A protein 2", "go_ids": ["GO:0006281", "GO:0006260", "GO:0003677", "GO:0005634", "GO:0006310"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0006260:DNA replication:P", "GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006310:DNA recombination:P"], "name": "Rfa2/RPA32", "pathway_ids": ["R-RNO-110312", "R-RNO-174437", "R-HSA-5693616", "R-SPO-5656169", "R-SPO-5656121", "R-HSA-5696397", "R-MMU-110320", "R-RNO-5655862", "R-MMU-6804756", "R-RNO-176187", "R-RNO-110314", "R-MMU-5685938", "R-HSA-5655862", "R-MMU-110314", "R-MMU-69473", "R-MMU-5696395", "R-SPO-5696395", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-RNO-5696397", "R-MMU-174437", "R-RNO-5656169", "R-HSA-5656121", "R-MMU-5358606", "R-MMU-5358565", "R-SPO-69166", "R-RNO-6782210", "R-SPO-176187", "R-RNO-5656121", "R-HSA-69473", "R-MMU-68962", "R-MMU-5651801", "R-RNO-5696395", "R-RNO-5693607", "R-HSA-110312", "R-HSA-6783310", "R-RNO-69473", "R-HSA-6804756", "R-SPO-110314", "R-HSA-5696395", "R-MMU-176187", "R-MMU-6782210", "R-MMU-5696397", "R-HSA-110314", "R-SCE-6782135", "R-SPO-5651801", "R-HSA-3371511", "R-RNO-68962", "R-RNO-3371453", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5655862", "R-HSA-5358606", "R-MMU-110312", "R-SPO-110312", "R-RNO-69166", "R-RNO-5685938", "R-HSA-912446", "R-HSA-68962", "R-HSA-6782210", "R-RNO-6804756", "R-HSA-5656169", "R-SCE-6782210", "R-SCE-176187", "R-HSA-5685938", "R-HSA-176187", "R-MMU-5696400", "R-MMU-5693607", "R-MMU-3371453", "R-MMU-5655862", "R-RNO-5358606", "R-SPO-5696397", "R-RNO-5358565", "R-RNO-6782135", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-HSA-69166", "R-RNO-110320", "R-SCE-68962", "R-MMU-6783310", "R-RNO-5685942", "R-MMU-5656121", "R-SPO-5696400", "R-SPO-110320", "R-SPO-6782210", "R-MMU-69166", "R-RNO-5696400", "R-HSA-5696400", "R-HSA-5358565", "R-SPO-68962", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-HSA-110320", "R-RNO-6783310"], "pathways": ["R-RNO-110312:r:Translesion synthesis by REV1", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-110312:r:Translesion synthesis by REV1", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-3371511:r:HSF1 activation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-RNO-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR014647": {"description": "CST complex subunit Stn1", "go_ids": ["GO:0016233", "GO:1990879", "GO:0043047"], "go_terms": ["GO:0016233:telomere capping:P", "GO:1990879:CST complex:C", "GO:0043047:single-stranded telomeric DNA binding:F"], "name": "Stn1", "pathway_ids": ["R-BTA-174411", "R-MMU-174430", "R-BTA-174430", "R-RNO-174430", "R-DRE-174430", "R-HSA-174430", "R-MMU-174411", "R-HSA-174411", "R-RNO-174411"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere"], "type": "Family"}, "IPR014648": {"description": "Neuropilin", "go_ids": ["GO:0001525", "GO:0007411", "GO:0038084", "GO:0005021", "GO:0017154"], "go_terms": ["GO:0001525:angiogenesis:P", "GO:0007411:axon guidance:P", "GO:0038084:vascular endothelial growth factor signaling pathway:P", "GO:0005021:vascular endothelial growth factor receptor activity:F", "GO:0017154:semaphorin receptor activity:F"], "name": "Neuropilin", "pathway_ids": ["R-HSA-399956", "R-RNO-399956", "R-DRE-399954", "R-RNO-445144", "R-MMU-399955", "R-HSA-376176", "R-DRE-194306", "R-HSA-9694614", "R-MMU-445144", "R-HSA-194306", "R-HSA-447041", "R-RNO-399954", "R-MMU-194306", "R-RNO-399955", "R-HSA-399954", "R-DRE-399956", "R-MMU-399954", "R-HSA-399955", "R-HSA-445144", "R-HSA-447038", "R-MMU-399956", "R-RNO-194306"], "pathways": ["R-HSA-399956:r:CRMPs in Sema3A signaling", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-445144:r:Signal transduction by L1", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-376176:r:Signaling by ROBO receptors", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-9694614:r:Attachment and Entry", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-447041:r:CHL1 interactions", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-447038:r:NrCAM interactions", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR"], "type": "Family"}, "IPR014651": {"description": "Uncharacterised conserved protein, 2xCBS, MJ1404 type", "go_ids": [], "go_terms": [], "name": "UCP036983_2CBS_MJ1404", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014709": {"description": "Glutathione synthase, C-terminal, eukaryotic", "go_ids": [], "go_terms": [], "name": "Glutathione_synthase_C_euk", "pathway_ids": ["PWY-8043", "R-RNO-174403", "R-HSA-174403", "R-HSA-5579006", "R-DDI-174403", "R-MMU-174403", "R-SCE-174403", "R-SPO-174403"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-HSA-5579006:r:Defective GSS causes GSS deficiency", "R-DDI-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis 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"R-CFA-2485179:r:Activation of the phototransduction cascade", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-HSA-180024:r:DARPP-32 events", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-354192:r:Integrin signaling", "R-MMU-1296072:r:Voltage gated Potassium channels", "R-GGA-180024:r:DARPP-32 events", "R-RNO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-CEL-392517:r:Rap1 signalling", "R-MMU-6814848:r:Glycerophospholipid catabolism", "R-DDI-446205:r:Synthesis of GDP-mannose", "R-MMU-71240:r:Tryptophan catabolism", "R-CFA-1296072:r:Voltage gated Potassium channels", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-GGA-5610787:r:Hedgehog 'off' state", "R-BTA-446205:r:Synthesis of GDP-mannose", "R-RNO-8935690:r:Digestion", "R-SCE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-180024:r:DARPP-32 events", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DDI-1237112:r:Methionine salvage pathway", "R-CEL-1614558:r:Degradation of cysteine and homocysteine", "R-BTA-180024:r:DARPP-32 events", "R-DRE-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DDI-1614558:r:Degradation of cysteine and homocysteine", "R-DRE-1234174:r:Cellular response to hypoxia", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-163615:r:PKA activation", "R-PFA-164378:r:PKA activation in glucagon signalling"], "type": "Homologous_superfamily"}, "IPR014711": {"description": "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type", "go_ids": ["GO:0003677", "GO:0003917", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003917:DNA topoisomerase type I (single strand cut, ATP-independent) activity:F", "GO:0006265:DNA topological change:P"], "name": "TopoI_cat_a-hlx-sub_euk", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-HSA-4615885", "R-SPO-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Homologous_superfamily"}, "IPR014712": {"description": "ANTH domain superfamily", "go_ids": ["GO:0005545", "GO:0030276", "GO:0048268", "GO:0030136"], "go_terms": ["GO:0005545:1-phosphatidylinositol binding:F", "GO:0030276:clathrin binding:F", "GO:0048268:clathrin coat assembly:P", "GO:0030136:clathrin-coated vesicle:C"], "name": "ANTH_dom_sf", "pathway_ids": ["R-DME-8856825", "R-MMU-8856828", "R-CEL-8856828", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-RNO-9696264", "R-MMU-432722", "R-DME-8856828", "R-RNO-8856828", "R-CEL-432722", "R-MMU-9696264", "R-DME-432722", "R-HSA-432722", "R-CEL-8856825", "R-RNO-432722", "R-HSA-9696264"], "pathways": ["R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9696264:r:RND3 GTPase cycle", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR014714": {"description": "Glutamate mutase E subunit, C-terminal domain superfamily", "go_ids": ["GO:0016866", "GO:0031419"], "go_terms": ["GO:0016866:intramolecular transferase activity:F", "GO:0031419:cobalamin binding:F"], "name": "Glu_mut_E_C_dom_sf", "pathway_ids": ["PWY-6728", "PWY-5087", "PWY-5103"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5087:t:L-glutamate degradation VI (to pyruvate)", "PWY-5103:t:L-isoleucine biosynthesis III"], "type": "Homologous_superfamily"}, "IPR014716": {"description": "Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1", "go_ids": [], "go_terms": [], "name": "Fibrinogen_a/b/g_C_1", "pathway_ids": ["R-HSA-6798695", "R-HSA-1989781", "R-BTA-9762292", "R-HSA-5674135", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-BTA-5673001", "R-HSA-8963889", "R-RNO-140875", "R-BTA-6798695", "R-MMU-210993", "R-MMU-8957275", "R-HSA-2855086", "R-HSA-9841922", "R-MMU-3000178", "R-HSA-9649948", "R-MMU-381426", "R-HSA-6803157", "R-RNO-8963889", "R-HSA-166663", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-6802955", "R-HSA-381426", "R-RNO-3000178", "R-RNO-5686938", "R-HSA-166058", "R-RNO-210993", "R-HSA-6802948", "R-HSA-210993", "R-BTA-8963889", "R-MMU-5686938", "R-MMU-9762292", "R-SSC-8963889", "R-HSA-5673001", "R-RNO-381426", "R-RNO-2855086", "R-MMU-216083", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-1236974", "R-HSA-5603041", "R-HSA-372708", "R-MMU-354192", "R-RNO-6798695", "R-HSA-9656223", "R-MMU-114608", "R-SSC-9762292", "R-HSA-9029558", "R-MMU-5674135", "R-RNO-216083", "R-HSA-977225", "R-CFA-210993", "R-MMU-2855086", "R-RNO-9762292", "R-RNO-354194", "R-RNO-114608", "R-MMU-372708", "R-HSA-114608", "R-RNO-354192", "R-HSA-6802946", "R-RNO-8957275", "R-MMU-6803157", "R-RNO-5674135", "R-HSA-5686938", "R-BTA-2129379", "R-HSA-354192", "R-HSA-2129379", "R-HSA-216083", "R-HSA-3000170", "R-HSA-381340", "R-MMU-8963889", "R-HSA-354194", "R-MMU-354194", "R-HSA-140875", "R-MMU-140875", "R-HSA-166662", "R-BTA-210993", "R-HSA-5602498", "R-HSA-8957275", "R-BTA-2855086", "R-MMU-2129379"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1989781:r:PPARA activates gene expression", "R-BTA-9762292:r:Regulation of CDH11 function", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-210993:r:Tie2 Signaling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-166663:r:Initial triggering of complement", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-210993:r:Tie2 Signaling", "R-BTA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-9762292:r:Regulation of CDH11 function", "R-SSC-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-114608:r:Platelet degranulation", "R-SSC-9762292:r:Regulation of CDH11 function", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-977225:r:Amyloid fiber formation", "R-CFA-210993:r:Tie2 Signaling", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-RNO-9762292:r:Regulation of CDH11 function", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-114608:r:Platelet degranulation", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-RNO-354192:r:Integrin signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-6803157:r:Antimicrobial peptides", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-HSA-354192:r:Integrin signaling", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-166662:r:Lectin pathway of complement activation", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Homologous_superfamily"}, "IPR014717": {"description": "Translation elongation factor EF1B/small ribosomal subunit protein bS6", "go_ids": [], "go_terms": [], "name": "Transl_elong_EF1B/ribsomal_bS6", "pathway_ids": ["R-MMU-156842", "R-HSA-5419276", "R-MMU-9937383", "R-BTA-156842", "R-RNO-156842", "R-HSA-156842", "R-XTR-156842", "R-HSA-9937383", "R-BTA-9937383", "R-SPO-156842", "R-BTA-5389840", "R-SSC-156842", "R-HSA-5368286", "R-SCE-156842", "R-MMU-5419276", "R-BTA-5419276", "R-DME-5419276", "R-DME-5389840", "R-HSA-5389840", "R-DME-156842", "R-MMU-5389840", "R-DME-9937383", "R-DDI-156842"], "pathways": ["R-MMU-156842:r:Eukaryotic Translation Elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-156842:r:Eukaryotic Translation Elongation", "R-RNO-156842:r:Eukaryotic Translation Elongation", "R-HSA-156842:r:Eukaryotic Translation Elongation", "R-XTR-156842:r:Eukaryotic Translation Elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-SPO-156842:r:Eukaryotic Translation Elongation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-SSC-156842:r:Eukaryotic Translation Elongation", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-SCE-156842:r:Eukaryotic Translation Elongation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DME-156842:r:Eukaryotic Translation Elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-DDI-156842:r:Eukaryotic Translation Elongation"], "type": "Homologous_superfamily"}, "IPR014718": {"description": "Glycoside hydrolase-type carbohydrate-binding", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "GH-type_carb-bd", "pathway_ids": ["R-HSA-70370", "R-MMU-70370", "R-HSA-9931929", "R-SPO-70370", "R-RNO-70370", "R-SCE-70370", "R-BTA-70370", "R-SSC-70370"], "pathways": ["R-HSA-70370:r:Galactose catabolism", "R-MMU-70370:r:Galactose catabolism", "R-HSA-9931929:r:Defective GALM causes GALAC4", "R-SPO-70370:r:Galactose catabolism", "R-RNO-70370:r:Galactose catabolism", "R-SCE-70370:r:Galactose catabolism", "R-BTA-70370:r:Galactose catabolism", "R-SSC-70370:r:Galactose catabolism"], "type": "Homologous_superfamily"}, "IPR014719": {"description": "Ribosomal protein bL12, C-terminal/adaptor protein ClpS-like", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL12_C/ClpS-like", "pathway_ids": ["R-DME-983168", "R-MMU-9837999", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-9937383", "R-HSA-983168", "R-BTA-9937383", "R-CEL-983168", "R-BTA-5389840", "R-HSA-5368286", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-MMU-983168", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9837999", "R-HSA-5389840", "R-MMU-5389840"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation 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activation via ZBP1", "R-DRE-9762293:r:Regulation of CDH11 gene transcription", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DME-77042:r:Formation of editosomes by ADAR proteins", "R-MMU-9762293:r:Regulation of CDH11 gene transcription", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9833482:r:PKR-mediated signaling", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-CEL-75102:r:C6 deamination of adenosine", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-203927:r:MicroRNA (miRNA) biogenesis", "R-RNO-75102:r:C6 deamination of adenosine", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DRE-9833482:r:PKR-mediated signaling", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-BTA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9762293:r:Regulation of CDH11 gene transcription", "R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DME-9833482:r:PKR-mediated 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PE", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine", "R-DME-538864:r:Degradation of CRY", "R-MMU-8876725:r:Protein methylation", "R-HSA-1483191:r:Synthesis of PC", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-DME-432395:r:Degradation of TIM", "R-SCE-1483213:r:Synthesis of PE", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-RNO-8876725:r:Protein methylation", "R-BTA-70635:r:Urea cycle", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SPO-9748787:r:Azathioprine ADME", "R-SCE-611105:r:Respiratory electron transport", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-SSC-611105:r:Respiratory electron transport", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR014730": {"description": "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "ETF_a/b_N", "pathway_ids": ["R-SSC-611105", "R-RNO-611105", "R-HSA-611105", "R-HSA-8876725", "R-DDI-611105", "R-SSC-8876725", "R-CEL-611105", "R-RNO-8876725", "R-MMU-611105", "R-SPO-611105", "R-SCE-611105", "R-DME-611105", "R-MMU-8876725"], "pathways": ["R-SSC-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-8876725:r:Protein methylation", "R-DDI-611105:r:Respiratory electron transport", "R-SSC-8876725:r:Protein methylation", "R-CEL-611105:r:Respiratory electron transport", "R-RNO-8876725:r:Protein methylation", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-DME-611105:r:Respiratory electron transport", "R-MMU-8876725:r:Protein methylation"], "type": "Domain"}, "IPR014731": {"description": "Electron transfer flavoprotein, alpha subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "ETF_asu_C", "pathway_ids": ["R-DDI-611105", "R-RNO-611105", "R-HSA-611105", "R-SPO-611105", "R-SCE-611105", "R-DME-611105", "R-CEL-611105", "R-MMU-611105"], "pathways": ["R-DDI-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-DME-611105:r:Respiratory electron transport", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR014732": {"description": "Orotidine 5'-phosphate decarboxylase", "go_ids": ["GO:0044205", "GO:0004590"], "go_terms": ["GO:0044205:'de novo' UMP biosynthetic process:P", "GO:0004590:orotidine-5'-phosphate decarboxylase activity:F"], "name": "OMPdecase", "pathway_ids": ["PWY-7791", "PWY-5686", "PWY-7790", "R-MMU-500753", "R-CEL-500753", "R-DME-500753", "R-DDI-500753", "R-HSA-500753"], "pathways": ["PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "R-MMU-500753:r:Pyrimidine biosynthesis", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-DME-500753:r:Pyrimidine biosynthesis", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-HSA-500753:r:Pyrimidine biosynthesis"], "type": "Family"}, "IPR014735": {"description": "Transposase, Tn5-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Transposase_Tn5-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014737": {"description": "Transposase, Tn5-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Transposase_Tn5-like_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR014738": {"description": "Citrate transporter", "go_ids": ["GO:0015746", "GO:0015137"], "go_terms": ["GO:0015746:citrate transport:P", "GO:0015137:citrate transmembrane transporter activity:F"], "name": "Citrate_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014739": {"description": "Channel forming colicin, N-terminal domain superfamily", "go_ids": ["GO:0031640", "GO:0140911", "GO:0016020", "GO:0050829"], "go_terms": ["GO:0031640:killing of cells of another organism:P", "GO:0140911:pore-forming activity:F", "GO:0016020:membrane:C", "GO:0050829:defense response to Gram-negative bacterium:P"], "name": "Channel_colicin_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR014740": {"description": "Channel forming colicin, central receptor recognition", "go_ids": ["GO:0031640", "GO:0016020", "GO:0050829"], "go_terms": ["GO:0031640:killing of cells of another organism:P", "GO:0016020:membrane:C", "GO:0050829:defense response to Gram-negative bacterium:P"], "name": "Channel_colicin_cen", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014741": {"description": "Adaptor protein Cbl, EF hand-like", "go_ids": ["GO:0005509"], "go_terms": ["GO:0005509:calcium ion binding:F"], "name": "Adaptor_Cbl_EF_hand-like", "pathway_ids": ["PWY-7511", "R-HSA-8849469", "R-MMU-8856828", "R-MMU-182971", "R-MMU-1433559", "R-HSA-1059683", "R-MMU-8856825", "R-HSA-8856828", "R-HSA-912631", "R-MMU-1295596", "R-HSA-1236382", "R-RNO-983168", "R-MMU-5654732", "R-HSA-2173789", "R-HSA-9706369", "R-MMU-912631", "R-HSA-182971", "R-HSA-5654727", "R-MMU-2173789", "R-MMU-8849469", "R-HSA-5654726", "R-HSA-5654732", "R-MMU-9706369", "R-HSA-6807004", "R-HSA-983168", "R-HSA-5637810", "R-HSA-9706377", "R-MMU-5654726", "R-DDI-983168", "R-HSA-1433559", "R-MMU-1059683", "R-HSA-1295596", "R-HSA-8856825", "R-MMU-5654727", "R-MMU-983168", "R-MMU-5654733", "R-MMU-6807004", "R-HSA-5654733", "R-HSA-8875360", "R-HSA-9680350"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-182971:r:EGFR downregulation", "R-MMU-1433559:r:Regulation of KIT signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-912631:r:Regulation of signaling by CBL", "R-HSA-182971:r:EGFR downregulation", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells"], "type": "Domain"}, "IPR014742": {"description": "Adaptor protein Cbl, SH2-like domain", "go_ids": [], "go_terms": [], "name": "Adaptor_Cbl_SH2-like", "pathway_ids": ["PWY-7511", "R-HSA-8849469", "R-MMU-8856828", "R-MMU-182971", "R-MMU-1433559", "R-HSA-1059683", "R-MMU-8856825", "R-HSA-8856828", "R-HSA-912631", "R-MMU-1295596", "R-HSA-1236382", "R-RNO-983168", "R-MMU-5654732", "R-HSA-2173789", "R-HSA-9706369", "R-MMU-912631", "R-HSA-182971", "R-HSA-5654727", "R-MMU-2173789", "R-MMU-8849469", "R-HSA-5654726", "R-HSA-5654732", "R-MMU-9706369", "R-HSA-6807004", "R-HSA-983168", "R-HSA-5637810", "R-HSA-9706377", "R-MMU-5654726", "R-HSA-1433559", "R-MMU-1059683", "R-HSA-1295596", "R-HSA-8856825", "R-MMU-5654727", "R-MMU-983168", "R-MMU-5654733", "R-MMU-6807004", "R-HSA-5654733", "R-HSA-8875360", "R-HSA-9680350"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-182971:r:EGFR downregulation", "R-MMU-1433559:r:Regulation of KIT signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-912631:r:Regulation of signaling by CBL", "R-HSA-182971:r:EGFR downregulation", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells"], "type": "Domain"}, "IPR014743": {"description": "Chloride channel, core", "go_ids": [], "go_terms": [], "name": "Cl-channel_core", "pathway_ids": ["R-CEL-2672351", "R-RNO-2672351", "R-DDI-2672351", "R-MMU-2672351", "R-HSA-6802952", "R-DME-2672351", "R-SSC-2672351", "R-SPO-2672351", "R-HSA-2672351", "R-CFA-2672351", "R-SCE-2672351", "R-BTA-2672351"], "pathways": ["R-CEL-2672351:r:Stimuli-sensing channels", "R-RNO-2672351:r:Stimuli-sensing channels", "R-DDI-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-DME-2672351:r:Stimuli-sensing channels", "R-SSC-2672351:r:Stimuli-sensing channels", "R-SPO-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-CFA-2672351:r:Stimuli-sensing channels", "R-SCE-2672351:r:Stimuli-sensing channels", "R-BTA-2672351:r:Stimuli-sensing channels"], "type": "Homologous_superfamily"}, "IPR014744": {"description": "Nuclear receptor coactivator, CREB-bp-like, interlocking", "go_ids": ["GO:0000123", "GO:0003713", "GO:0004402", "GO:0005634", "GO:0006355"], "go_terms": ["GO:0000123:histone acetyltransferase complex:C", "GO:0003713:transcription coactivator activity:F", "GO:0004402:histone acetyltransferase activity:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Nuc_rcpt_coact_CREBbp", "pathway_ids": ["PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", 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"PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-MMU-8941858", "R-RNO-933541", "R-HSA-8936459", "R-RNO-9018519", "R-HSA-9818030", "R-HSA-9616222", "R-HSA-9701898", "R-HSA-9614657", "R-HSA-2122947", "R-MMU-6804760", "R-HSA-9931521", "R-HSA-6804760", "R-RNO-9759194", "R-MMU-3371568", "R-MMU-350054", "R-HSA-6804114", "R-MMU-6804758", "R-HSA-9793380", "R-RNO-9841922", "R-RNO-5621575", "R-HSA-2644606", "R-HSA-9031628", "R-HSA-9768919", "R-HSA-9833109", "R-HSA-8941856", "R-HSA-9705671", "R-MMU-2122947", "R-HSA-9735871", "R-MMU-9759194", "R-MMU-9029569", "R-HSA-3371568", "R-HSA-9818028", "R-HSA-9617629", "R-RNO-400206", "R-MMU-8951936", "R-HSA-9839394", "R-MMU-3899300", "R-RNO-9856649", "R-HSA-210744", "R-HSA-156711", "R-HSA-381340", "R-MMU-8866907", "R-MMU-9701898", "R-HSA-9707616", "R-HSA-6811555", "R-HSA-350054", "R-HSA-201722", "R-HSA-933541", "R-HSA-9909649", "R-RNO-8941856", "R-RNO-8866907", "R-HSA-3214847", "R-HSA-9856649", "R-RNO-9617629", "R-HSA-2426168", "R-MMU-9707564", "R-MMU-9856649", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-1234158", "R-MMU-5689901", "R-MMU-201722", "R-MMU-8939246", "R-HSA-9818749", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-1234158", "R-RNO-350054", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-9018519", "R-HSA-8951936", "R-RNO-3134973", "R-MMU-8936459", "R-MMU-5250924", "R-MMU-5621575", "R-HSA-8941858", "R-MMU-3134973", "R-MMU-9018519", "R-HSA-9013695", "R-HSA-8939243", "R-HSA-9818026", "R-HSA-400206", "R-HSA-3134973", "R-MMU-400206", "R-HSA-5617472", "R-HSA-9818027", "R-HSA-5689901", "R-HSA-9819196", "R-MMU-933541", "R-RNO-201722", "R-HSA-9818035", "R-MMU-9617629", "R-RNO-8939246", "R-HSA-1912408", "R-HSA-6804758", "R-RNO-3371568", "R-HSA-918233", "R-HSA-5621575", "R-HSA-9759194", "R-HSA-9029569", "R-HSA-2173796", "R-HSA-9931509", "R-HSA-8866907", "R-HSA-9013508", "R-HSA-2894862", "R-RNO-9707564", "R-MMU-8939243", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-6803204", "R-HSA-9818032", "R-MMU-8941856", "R-HSA-5250924", "R-MMU-6811555", "R-RNO-1234158", "R-HSA-3899300", "R-HSA-2197563", "R-HSA-8939246", "PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711"], "pathways": ["PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-3371568:r:Attenuation phase", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-3371568:r:Attenuation phase", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-9839394:r:TGFBR3 expression", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9707616:r:Heme signaling", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-3371568:r:Attenuation phase", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis"], "type": "Domain"}, "IPR014745": {"description": "MHC class II, alpha/beta chain, N-terminal", "go_ids": ["GO:0006955", "GO:0016020", "GO:0019882", "GO:0042613"], "go_terms": ["GO:0006955:immune response:P", "GO:0016020:membrane:C", "GO:0019882:antigen processing and presentation:P", "GO:0042613:MHC class II protein complex:C"], "name": "MHC_II_a/b_N", "pathway_ids": ["R-HSA-2132295", "R-SSC-202427", "R-HSA-202433", "R-RNO-202433", "R-MMU-202430", "R-HSA-202427", "R-SSC-2132295", "R-RNO-202427", "R-SSC-202433", "R-MMU-2132295", "R-RNO-202424", "R-HSA-202430", "R-MMU-202424", "R-MMU-389948", "R-MMU-202433", "R-RNO-2132295", "R-SSC-202424", "R-SSC-202430", "R-HSA-202424", "R-HSA-877300", "R-SSC-389948", "R-RNO-389948", "R-MMU-202427", "R-RNO-202430", "R-HSA-389948"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-202433:r:Generation of second messenger molecules", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-2132295:r:MHC class II antigen presentation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-202433:r:Generation of second messenger molecules", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-202433:r:Generation of second messenger molecules", "R-RNO-2132295:r:MHC class II antigen presentation", "R-SSC-202424:r:Downstream TCR signaling", "R-SSC-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-389948:r:Co-inhibition by PD-1", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-389948:r:Co-inhibition by PD-1"], "type": "Homologous_superfamily"}, "IPR014746": {"description": "Glutamine synthetase/guanido kinase, catalytic domain", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Gln_synth/guanido_kin_cat_dom", "pathway_ids": ["R-HSA-71288", "R-MMU-210455", "R-SSC-71288", "R-CFA-71288", "R-DME-210455", "R-RNO-210455", "R-SCE-210455", "R-BTA-210455", "R-CFA-9696264", "R-RNO-8964539", "R-DME-174403", "R-SPO-174403", "R-HSA-210455", "R-CEL-8964539", "R-HSA-174403", "R-GGA-9696264", "R-BTA-8964539", "R-RNO-174403", "R-MMU-8964539", "R-BTA-71288", "R-GGA-71288", "R-HSA-9696264", "R-HSA-8964539", "R-DME-8964539", "R-SPO-8964539", "R-CEL-210455", "R-MMU-71288", "R-MMU-174403", "R-BTA-9696264", "R-RNO-71288", "R-RNO-9696264", "R-CEL-174403", "R-SCE-8964539", "R-HSA-5578999", "R-MMU-9696264", "R-SPO-210455", "R-HSA-9818027"], "pathways": ["R-HSA-71288:r:Creatine metabolism", "R-MMU-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-SSC-71288:r:Creatine metabolism", "R-CFA-71288:r:Creatine metabolism", "R-DME-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-RNO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-SCE-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-BTA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CFA-9696264:r:RND3 GTPase cycle", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-DME-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-HSA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-GGA-9696264:r:RND3 GTPase cycle", "R-BTA-8964539:r:Glutamate and glutamine metabolism", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-BTA-71288:r:Creatine metabolism", "R-GGA-71288:r:Creatine metabolism", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-DME-8964539:r:Glutamate and glutamine metabolism", "R-SPO-8964539:r:Glutamate and glutamine metabolism", "R-CEL-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-MMU-71288:r:Creatine metabolism", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-BTA-9696264:r:RND3 GTPase cycle", "R-RNO-71288:r:Creatine metabolism", "R-RNO-9696264:r:RND3 GTPase cycle", "R-CEL-174403:r:Glutathione synthesis and recycling", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-HSA-5578999:r:Defective GCLC causes HAGGSD", "R-MMU-9696264:r:RND3 GTPase cycle", "R-SPO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes"], "type": "Homologous_superfamily"}, "IPR014747": {"description": "Bacterial photosynthetic reaction centre, H-chain, C-terminal", "go_ids": ["GO:0019684", "GO:0030077"], "go_terms": ["GO:0019684:photosynthesis, light reaction:P", "GO:0030077:plasma membrane light-harvesting complex:C"], "name": "Bac_photo_RC_H_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR014748": {"description": "Enoyl-CoA hydratase, C-terminal", "go_ids": [], "go_terms": [], "name": "Enoyl-CoA_hydra_C", "pathway_ids": ["R-RNO-77352", "R-MMU-9837999", "R-RNO-77346", "R-CEL-77348", "R-CEL-77350", "R-DDI-70895", "R-RNO-77310", "R-HSA-77350", "R-HSA-77346", "R-MMU-77352", "R-RNO-9033241", "R-MMU-77346", "R-RNO-77350", "R-MMU-70895", "R-CEL-70895", "R-MMU-77310", "R-RNO-77348", "R-BTA-77352", "R-HSA-9837999", "R-HSA-77352", "R-DDI-9033241", "R-CEL-77346", "R-DDI-9837999", "R-BTA-70895", "R-HSA-9914274", "R-HSA-9916720", "R-CEL-77352", "R-MMU-77350", "R-BTA-77310", "R-HSA-70895", "R-MMU-9033241", "R-CEL-77310", "R-HSA-77348", "R-DDI-77346", "R-DDI-77350", "R-DDI-77310", "R-DDI-77348", "R-BTA-77348", "R-RNO-9837999", "R-RNO-70895", "R-MMU-77348", "R-BTA-77350", "R-HSA-77310", "R-BTA-77346", "R-HSA-390247", "R-MMU-390247", "R-DDI-77352", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-CEL-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-DDI-9033241:r:Peroxisomal protein import", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9914274:r:3-methylglutaconic aciduria", "R-HSA-9916720:r:Mitochondrial short-chain enoyl-CoA hydratase deficiency 1", "R-CEL-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-BTA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-CEL-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-DDI-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DDI-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-DDI-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Homologous_superfamily"}, "IPR014751": {"description": "DNA repair protein XRCC4-like, C-terminal", "go_ids": [], "go_terms": [], "name": "XRCC4-like_C", "pathway_ids": ["R-CEL-8980692", "R-HSA-3108214", "R-DDI-5693571", "R-HSA-9013424", "R-MMU-445355", "R-CEL-416482", "R-CEL-9013407", "R-HSA-9725370", "R-RNO-445355", "R-RNO-9013424", "R-CEL-3928662", "R-DME-9013407", "R-RNO-390522", "R-HSA-445355", "R-DME-8980692", "R-SSC-9013424", "R-MMU-390522", "R-DME-3928662", "R-MMU-9013424", "R-HSA-2029482", "R-CEL-416572", "R-DME-9013422", "R-DME-4420097", "R-DME-5627117", "R-CEL-5627117", "R-MMU-2029482", "R-HSA-164843", "R-SSC-390522", "R-HSA-5693571", "R-DME-416572", "R-CEL-4420097", "R-SSC-445355", "R-HSA-390522", "R-DME-416482", "R-MMU-3108214", "R-HSA-9664422", "R-DDI-3108214", "R-MMU-5693571"], "pathways": ["R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-445355:r:Smooth Muscle Contraction", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-445355:r:Smooth Muscle Contraction", "R-RNO-9013424:r:RHOV GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-DME-9013407:r:RHOH GTPase cycle", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-DME-8980692:r:RHOA GTPase cycle", "R-SSC-9013424:r:RHOV GTPase cycle", "R-MMU-390522:r:Striated Muscle Contraction", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-164843:r:2-LTR circle formation", "R-SSC-390522:r:Striated Muscle Contraction", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-SSC-445355:r:Smooth Muscle Contraction", "R-HSA-390522:r:Striated Muscle Contraction", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DDI-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Homologous_superfamily"}, "IPR014752": {"description": "Arrestin-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Arrestin-like_C_sf", "pathway_ids": ["R-MMU-8856828", "R-HSA-5674135", "R-BTA-5689880", "R-HSA-6802952", "R-HSA-5689880", "R-HSA-8856828", "R-CEL-5099900", "R-SSC-844456", "R-MMU-5099900", "R-HSA-2485179", "R-CEL-432722", "R-BTA-2514859", "R-RNO-3238698", "R-SPO-3238698", "R-XTR-3238698", "R-MMU-5689880", "R-MMU-456926", "R-HSA-9649948", "R-HSA-9707564", "R-HSA-6802955", "R-RNO-432722", "R-DME-5674135", "R-HSA-6802948", "R-MMU-5635838", "R-HSA-2514859", "R-RNO-432720", "R-DRE-3238698", "R-HSA-456926", "R-HSA-432720", "R-HSA-3238698", "R-HSA-9660826", "R-HSA-418555", "R-CEL-5674135", "R-RNO-844456", "R-CEL-456926", "R-RNO-5689880", "R-RNO-456926", "R-HSA-5635838", "R-BTA-418555", "R-CEL-8856825", "R-RNO-2514859", "R-HSA-844456", "R-HSA-9656223", "R-RNO-418555", "R-DME-432720", "R-DME-418555", "R-MMU-5674135", "R-HSA-2122948", "R-MMU-3238698", "R-MMU-8856825", "R-CEL-432720", "R-MMU-432722", "R-CEL-3238698", "R-CEL-844456", "R-BTA-3238698", "R-BTA-5674135", "R-HSA-9839389", "R-BTA-9839389", "R-HSA-6802946", "R-MMU-2514859", "R-DME-8856828", "R-RNO-8856828", "R-RNO-5674135", "R-RNO-9839389", "R-RNO-5099900", "R-HSA-432722", "R-MMU-432720", "R-HSA-9617629", "R-BTA-8856828", "R-DME-8856825", "R-CEL-8856828", "R-BTA-5635838", "R-RNO-8856825", "R-MMU-9839389", "R-DDI-3238698", "R-BTA-432720", "R-BTA-456926", "R-DME-3238698", "R-HSA-5099900", "R-DME-432722", "R-SCE-3238698", "R-MMU-844456", "R-BTA-8856825", "R-HSA-8856825", "R-DME-9839389", "R-BTA-432722", "R-MMU-418555", "R-DME-5689880"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-SSC-844456:r:The NLRP3 inflammasome", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2514859:r:Inactivation, recovery and regulation of the 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"R-MMU-8856825", "R-MMU-422356", "R-MMU-432722", "R-HSA-2559582", "R-HSA-1169408", "R-DME-9860927", "R-HSA-5628897", "R-CEL-9013149", "R-MMU-1296053", "R-HSA-9615017", "R-DME-5620916", "R-DME-209394", "R-RNO-6804756", "R-BTA-997272", "R-HSA-9920951", "R-MMU-432720", "R-SCE-8964038", "R-HSA-9918481", "R-HSA-9734091", "R-DME-8856825", "R-RNO-6809371", "R-HSA-9013508", "R-HSA-382556", "R-SCE-3238698", "R-MMU-844456", "R-MMU-209563", "R-RNO-1296041", "R-HSA-1810476", "R-MMU-2871809", "R-MMU-9013026", "R-MMU-8941856", "R-MMU-983168", "R-HSA-9022699", "R-BTA-432722", "R-SSC-8875791", "R-BTA-5576886", "R-MMU-9696270", "R-HSA-975163", "R-MMU-8856828", "R-HSA-8874081", "R-HSA-6802952", "R-MMU-6811558", "R-HSA-140837", "R-HSA-2485179", "R-HSA-9918487", "R-RNO-72163", "R-DME-72163", "R-RNO-193692", "R-RNO-416550", "R-BTA-8941856", "R-RNO-399954", "R-CEL-1296067", "R-HSA-3134963", "R-DRE-5624138", "R-HSA-9844594", "R-MMU-9707616", "R-DME-214869", "R-MMU-1810476", "R-DME-5676590", "R-CFA-1296053", "R-GGA-1227892", "R-DME-446353", "R-HSA-5223345", "R-HSA-1296067", "R-HSA-5607761", "R-MMU-200425", "R-MMU-399955", "R-HSA-432720", "R-HSA-418555", "R-SSC-416550", "R-RNO-9013148", "R-CEL-5674135", "R-GGA-9954716", "R-BTA-1632852", "R-HSA-163125", "R-RNO-456926", "R-HSA-9820960", "R-HSA-6804756", "R-DDI-5674135", "R-DME-416572", "R-HSA-9918476", "R-DME-416700", "R-HSA-8865999", "R-DME-977068", "R-DME-350054", "R-MMU-1296025", "R-RNO-1257604", "R-RNO-8980692", "R-MMU-166166", "R-RNO-9734091", "R-DRE-983168", "R-MMU-8964038", "R-CEL-5620916", "R-DME-214416", "R-SCE-163680", "R-MMU-936964", "R-CEL-8856828", "R-SPO-5628897", "R-HSA-2871809", "R-HSA-5099900", "R-HSA-9707616", "R-MMU-1257604", "R-HSA-6807004", "R-DDI-5675221", "R-HSA-8856825", "R-HSA-5602498", "R-DME-9020702", "R-SSC-1296041", "R-MMU-937041", "R-DME-5689880", "R-CEL-8980692", "R-HSA-9920588", "R-MMU-9013106", "R-HSA-8856828", "R-HSA-166016", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-432722", "R-MMU-416572", "R-HSA-936964", "R-DRE-6798695", "R-RNO-72165", "R-MMU-399954", "R-HSA-1296041", "R-RNO-9013408", "R-HSA-1296025", "R-DDI-9013423", "R-SSC-997272", "R-RNO-5673001", "R-RNO-8865999", "R-HSA-5603029", "R-HSA-166058", "R-MMU-5620916", "R-HSA-209560", "R-MMU-5621575", "R-MMU-5635838", "R-RNO-5620916", "R-RNO-432720", "R-BTA-5624958", "R-HSA-9918432", "R-CFA-9648002", "R-SPO-8980692", "R-HSA-5678420", "R-BTA-1296053", "R-HSA-5635838", "R-RNO-1296067", "R-HSA-3878781", "R-MMU-6798695", "R-MMU-416700", "R-RNO-2514859", "R-MMU-114608", "R-SSC-1257604", "R-HSA-416550", "R-HSA-399956", "R-HSA-1296053", "R-HSA-9619483", "R-HSA-6809371", "R-DME-264876", "R-RNO-8875513", "R-HSA-2871837", "R-BTA-5674135", "R-HSA-112126", "R-HSA-8877330", "R-SPO-8964038", "R-HSA-416700", "R-HSA-5660668", "R-HSA-5621575", "R-MMU-2514859", "R-RNO-9839389", "R-HSA-432722", "R-HSA-380972", "R-RNO-1810476", "R-HSA-8875791", "R-HSA-8963896", "R-HSA-2894862", "R-GGA-434001", "R-HSA-8876493", "R-MMU-6806942", "R-HSA-5627123", "R-RNO-5607764", "R-MMU-8875656", "R-MMU-416482", "R-HSA-2197563", "R-SSC-8875656", "R-HSA-5689880", "R-RNO-1474228", "R-MMU-5624138", "R-MMU-4086398", "R-HSA-9918485", "R-MMU-9013408", "R-RNO-140875", "R-MMU-456926", "R-DDI-5213460", "R-DDI-5673000", "R-MMU-5673001", "R-MMU-163680", "R-RNO-6806942", "R-SSC-5576886", "R-HSA-9931269", "R-MMU-5624958", "R-MMU-72163", "R-HSA-9660826", "R-RNO-5628897", "R-HSA-416482", "R-SPO-9013148", "R-MMU-1296041", "R-CEL-9648002", "R-HSA-1445148", "R-HSA-9793380", "R-HSA-9013026", "R-MMU-5627123", "R-HSA-2644606", "R-CEL-8856825", "R-MMU-9860927", "R-RNO-8851907", "R-MMU-416550", "R-SSC-8875513", "R-HSA-416572", "R-DME-418555", "R-DME-432720", "R-HSA-5607763", "R-MMU-380972", "R-MMU-430116", "R-MMU-8980692", "R-MMU-2122947", "R-CEL-432720", "R-SCE-6798695", "R-HSA-9824878", "R-HSA-9013106", "R-HSA-9013423", "R-HSA-8851907", "R-RNO-2025928", "R-HSA-4086398", "R-MMU-202424", "R-HSA-9617629", "R-BTA-8856828", "R-MMU-382556", "R-DME-214411", "R-BTA-9931269", "R-SSC-8875555", "R-MMU-1169091", "R-SCE-3322077", "R-HSA-350054", "R-RNO-6807004", "R-HSA-9909649", "R-RNO-399955", "R-MMU-2562578", "R-HSA-8875656", "R-SPO-72163", "R-HSA-8875360", "R-HSA-8964038", "R-HSA-422356", "R-MMU-163125", "R-DRE-399954", "R-MMU-5607764", "R-DRE-8964038", "R-HSA-430116", "R-SSC-844456", "R-HSA-5676590", "R-CEL-416482", "R-RNO-5223345", "R-DME-933542", "R-SSC-6811558", "R-SPO-9013106", "R-BTA-1296041", "R-HSA-9649948", "R-HSA-3322077", "R-RNO-202424", "R-MMU-975163", "R-CEL-9013148", "R-MMU-193634", "R-BTA-9013407", "R-MMU-166016", "R-MMU-140837", "R-MMU-5578775", "R-RNO-9931269", "R-DME-1614517", "R-HSA-2151209", "R-CFA-5576886", "R-MMU-8875555", "R-HSA-9013149", "R-HSA-1169091", "R-HSA-8980692", "R-BTA-418555", "R-MMU-9931269", "R-RNO-445989", "R-RNO-8875555", "R-MMU-399956", "R-CEL-1296041", "R-HSA-8853884", "R-MMU-3322077", "R-HSA-2122948", "R-HSA-1614517", "R-DME-1810476", "R-CEL-416700", "R-GGA-5576886", "R-DDI-9013149", "R-HSA-1912408", "R-HSA-2025928", "R-SCE-8948751", "R-HSA-448706", "R-MMU-5607763", "R-HSA-3214841", "R-HSA-6802946", "R-DME-5607761", "R-DME-8856828", "R-HSA-5578775", "R-RNO-9013106", "R-HSA-9833110", "R-RNO-5099900", "R-HSA-937072", "R-HSA-5607764", "R-MMU-1614517", "R-BTA-5635838", "R-CEL-264876", "R-SSC-6807004", "R-SPO-380972", "R-RNO-5684264", "R-BTA-350054", "R-BTA-9013408", "R-MMU-8963896", "R-SSC-8851805", "R-CFA-1296041", "R-DDI-9954716", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-4755510:r:SUMOylation of immune response proteins", "R-MMU-1296067:r:Potassium transport channels", "R-CEL-9013407:r:RHOH GTPase cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SCE-200425:r:Carnitine shuttle", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-1632852:r:Macroautophagy", "R-MMU-448706:r:Interleukin-1 processing", "R-CEL-8964038:r:LDL clearance", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-GGA-1296053:r:Classical Kir channels", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-SSC-6798695:r:Neutrophil degranulation", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-9824272:r:Somitogenesis", "R-RNO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-CEL-844456:r:The NLRP3 inflammasome", "R-HSA-114608:r:Platelet degranulation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-CFA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-RNO-1296025:r:ATP sensitive Potassium channels", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-GGA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-5576886:r:Phase 4 - resting membrane potential", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-8852405:r:Signaling by MST1", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-5576886:r:Phase 4 - resting membrane potential", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-422356:r:Regulation of insulin secretion", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-RNO-9020702:r:Interleukin-1 signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-8875791:r:MET activates STAT3", "R-MMU-8865999:r:MET activates PTPN11", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-DME-5674135:r:MAP2K and MAPK activation", "R-MTU-868688:r:Trehalose biosynthesis", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-9648002:r:RAS processing", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-RNO-844456:r:The NLRP3 inflammasome", "R-RNO-5576886:r:Phase 4 - resting membrane potential", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-8963896:r:HDL assembly", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-6809371:r:Formation of the cornified envelope", "R-RNO-1614517:r:Sulfide oxidation to sulfate", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-CEL-1296053:r:Classical Kir channels", "R-MMU-264876:r:Insulin processing", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-913709:r:O-linked glycosylation of mucins", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-SPO-1632852:r:Macroautophagy", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-9013407:r:RHOH GTPase cycle", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-1296053:r:Classical Kir channels", "R-MMU-9648002:r:RAS processing", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-MMU-8852405:r:Signaling by MST1", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-8851805:r:MET activates RAS signaling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-446353:r:Cell-extracellular matrix interactions", "R-DDI-3295583:r:TRP channels", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-BTA-8964038:r:LDL clearance", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-DME-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-264876:r:Insulin processing", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-RNO-1632852:r:Macroautophagy", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9729555:r:Sensory perception of sour taste", "R-DDI-8964038:r:LDL clearance", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-114608:r:Platelet degranulation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-209563:r:Axonal growth stimulation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-209563:r:Axonal growth stimulation", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-DME-9648002:r:RAS processing", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-8851805:r:MET activates RAS signaling", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-DME-416482:r:G alpha (12/13) signalling events", "R-SSC-6806942:r:MET Receptor Activation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-9648002:r:RAS processing", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-5683177:r:Defective ABCC8 can cause hypo- and hyper-glycemias", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-SSC-8874081:r:MET activates PTK2 signaling", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-SSC-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-416700:r:Other semaphorin interactions", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-BTA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-8875791:r:MET activates STAT3", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-SCE-9013106:r:RHOC GTPase cycle", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-200425:r:Carnitine shuttle", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-877300:r:Interferon gamma signaling", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-SSC-8865999:r:MET activates PTPN11", "R-MMU-6807004:r:Negative regulation of MET activity", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DME-209560:r:NF-kB is activated and signals survival", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-448706:r:Interleukin-1 processing", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-SPO-200425:r:Carnitine shuttle", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9613354:r:Lipophagy", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DME-209400:r:Transcriptional activtion by phosphorylated DL/DIF dimer", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-GGA-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-8964038:r:LDL clearance", "R-RNO-264876:r:Insulin processing", "R-RNO-418555:r:G alpha (s) signalling events", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-RNO-1296053:r:Classical Kir channels", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-422356:r:Regulation of insulin secretion", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-1296053:r:Classical Kir channels", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-8964038:r:LDL clearance", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-SCE-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-844456:r:The NLRP3 inflammasome", "R-MMU-209563:r:Axonal growth stimulation", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SSC-8875791:r:MET activates STAT3", "R-BTA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-BTA-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-1296067:r:Potassium transport channels", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-MMU-9707616:r:Heme signaling", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-CFA-1296053:r:Classical Kir channels", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-HSA-1296067:r:Potassium transport channels", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-200425:r:Carnitine shuttle", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-418555:r:G alpha (s) signalling events", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-1632852:r:Macroautophagy", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-DME-416700:r:Other semaphorin interactions", "R-HSA-8865999:r:MET activates PTPN11", "R-DME-977068:r:Termination of O-glycan biosynthesis", "R-DME-350054:r:Notch-HLH transcription pathway", "R-MMU-1296025:r:ATP sensitive Potassium channels", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8964038:r:LDL clearance", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9707616:r:Heme signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-DME-9020702:r:Interleukin-1 signaling", "R-SSC-1296041:r:Activation of G protein gated Potassium channels", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-1296025:r:ATP sensitive Potassium channels", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-SSC-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-8865999:r:MET activates PTPN11", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-5635838:r:Activation of SMO", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CFA-9648002:r:RAS processing", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-5678420:r:Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome", "R-BTA-1296053:r:Classical Kir channels", "R-HSA-5635838:r:Activation of SMO", "R-RNO-1296067:r:Potassium transport channels", "R-HSA-3878781:r:Glycogen storage disease type IV (GBE1)", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-416700:r:Other semaphorin interactions", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-114608:r:Platelet degranulation", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-1296053:r:Classical Kir channels", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-HSA-6809371:r:Formation of the cornified envelope", "R-DME-264876:r:Insulin processing", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-SPO-8964038:r:LDL clearance", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-8963896:r:HDL assembly", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-SSC-8875656:r:MET receptor recycling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-DDI-5673000:r:RAF activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-6806942:r:MET Receptor Activation", "R-SSC-5576886:r:Phase 4 - resting membrane potential", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-CEL-9648002:r:RAS processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-418555:r:G alpha (s) signalling events", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-8875555:r:MET activates RAP1 and RAC1", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-3322077:r:Glycogen synthesis", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-8875656:r:MET receptor recycling", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8964038:r:LDL clearance", "R-HSA-422356:r:Regulation of insulin secretion", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DRE-8964038:r:LDL clearance", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-SSC-844456:r:The NLRP3 inflammasome", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-9013106:r:RHOC GTPase cycle", "R-BTA-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-3322077:r:Glycogen synthesis", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-5578775:r:Ion homeostasis", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DME-1614517:r:Sulfide oxidation to sulfate", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-CFA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-BTA-418555:r:G alpha (s) signalling events", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-CEL-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-MMU-3322077:r:Glycogen synthesis", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-1614517:r:Sulfide oxidation to sulfate", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-CEL-416700:r:Other semaphorin interactions", "R-GGA-5576886:r:Phase 4 - resting membrane potential", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9833110:r:RSV-host interactions", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-BTA-5635838:r:Activation of SMO", "R-CEL-264876:r:Insulin processing", "R-SSC-6807004:r:Negative regulation of MET activity", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-BTA-9013408:r:RHOG GTPase cycle", "R-MMU-8963896:r:HDL assembly", "R-SSC-8851805:r:MET activates RAS signaling", "R-CFA-1296041:r:Activation of G protein gated Potassium channels", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR014757": {"description": "Transcription regulator IclR, C-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_IclR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014758": {"description": "Methionyl-tRNA synthetase", "go_ids": ["GO:0000166", "GO:0004825", "GO:0005524", "GO:0006431"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004825:methionine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0006431:methionyl-tRNA aminoacylation:P"], "name": "Met-tRNA_synth", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-HSA-9856649", "R-DDI-9856649", "R-HSA-2408522", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Family"}, "IPR014760": {"description": "Serum albumin, N-terminal", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Serum_albumin_N", "pathway_ids": ["R-RNO-189451", "R-HSA-9757110", "R-HSA-2168880", "R-MMU-8957275", "R-HSA-189483", "R-RNO-114608", "R-RNO-9757110", "R-BTA-8957275", "R-HSA-114608", "R-HSA-196791", "R-RNO-9793528", "R-MMU-189483", "R-RNO-159418", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-9707564", "R-MMU-9749641", "R-RNO-189483", "R-RNO-8964058", "R-MMU-8964058", "R-HSA-381426", "R-MMU-2168880", "R-SSC-381426", "R-SSC-8957275", "R-MMU-189451", "R-HSA-8964058", "R-MMU-9757110", "R-RNO-2168880", "R-RNO-9707564", "R-MMU-9793528", "R-HSA-189451", "R-RNO-381426", "R-RNO-196791", "R-MMU-196791", "R-HSA-9749641", "R-HSA-9793528", "R-RNO-9749641", "R-HSA-8957275", "R-HSA-159418", "R-MMU-159418", "R-MMU-9707564", "R-MMU-114608"], "pathways": ["R-RNO-189451:r:Heme biosynthesis", "R-HSA-9757110:r:Prednisone ADME", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-189483:r:Heme degradation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-9757110:r:Prednisone ADME", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-MMU-189483:r:Heme degradation", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-189483:r:Heme degradation", "R-RNO-8964058:r:HDL remodeling", "R-MMU-8964058:r:HDL remodeling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-189451:r:Heme biosynthesis", "R-HSA-8964058:r:HDL remodeling", "R-MMU-9757110:r:Prednisone ADME", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-HSA-189451:r:Heme biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-RNO-9749641:r:Aspirin ADME", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-159418:r:Recycling of bile acids and salts", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR014764": {"description": "Defective-in-cullin neddylation protein", "go_ids": [], "go_terms": [], "name": "DCN-prot", "pathway_ids": ["R-MMU-8951664", "R-BTA-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-DME-8951664", "R-DRE-8951664", "R-GGA-8951664", "R-XTR-8951664", "R-CEL-8951664", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-GGA-8951664:r:Neddylation", "R-XTR-8951664:r:Neddylation", "R-CEL-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation"], "type": "Family"}, "IPR014771": {"description": "Apoptosis, Bim N-terminal", "go_ids": [], "go_terms": [], "name": "Apoptosis_Bim_N", "pathway_ids": ["R-MMU-111453", "R-HSA-193648", "R-HSA-9607240", "R-RNO-111453", "R-HSA-111453", "R-HSA-6802952", "R-MMU-193648", "R-HSA-111446", "R-HSA-9614657", "R-MMU-111446", "R-HSA-8862803", "R-RNO-111446", "R-HSA-8952158", "R-RNO-193648"], "pathways": ["R-MMU-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-MMU-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-RNO-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-RNO-193648:r:NRAGE signals death through JNK"], "type": "Domain"}, "IPR014773": {"description": "Virulence factor YopE, GAP domain", "go_ids": [], "go_terms": [], "name": "YopE_GAP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014774": {"description": "KaiC-like domain", "go_ids": [], "go_terms": [], "name": "KaiC-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014775": {"description": "L27 domain, C-terminal", "go_ids": [], "go_terms": [], "name": "L27_C", "pathway_ids": ["R-HSA-9013409", "R-HSA-420029", "R-HSA-212676", "R-MMU-9013408", "R-BTA-9013406", "R-RNO-9013149", "R-DRE-9013404", "R-MMU-9013404", "R-HSA-6794361", "R-BTA-9013423", "R-DRE-9013406", "R-HSA-9013423", "R-DME-264876", "R-RNO-212676", "R-RNO-5666185", "R-DME-5620916", "R-HSA-9662360", "R-BTA-212676", "R-XTR-9013423", "R-DRE-9013149", "R-HSA-9692912", "R-RNO-9013404", "R-RNO-9013406", "R-HSA-9013408", "R-RNO-9013408", "R-HSA-9705677", "R-MMU-5666185", "R-HSA-373753", "R-BTA-5666185", "R-DRE-9013408", "R-MMU-212676", "R-HSA-3000170", "R-CEL-6794361", "R-HSA-5666185", "R-HSA-9662361", "R-MMU-6794361", "R-XTR-9013408", "R-CEL-212676", "R-DME-212676", "R-HSA-9013404", "R-BTA-9013408", "R-RNO-9013423", "R-HSA-9013149", "R-MMU-9013423", "R-XTR-9013404", "R-XTR-9013406", "R-BTA-9013404", "R-MMU-9013406", "R-DME-6794361", "R-HSA-9013406", "R-RNO-6794361", "R-MMU-9013149", "R-HSA-9609736", "R-DRE-9013423"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-420029:r:Tight junction interactions", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-6794361:r:Neurexins and neuroligins", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-264876:r:Insulin processing", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-373753:r:Nephrin family interactions", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DRE-9013408:r:RHOG GTPase cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-3000170:r:Syndecan interactions", "R-CEL-6794361:r:Neurexins and neuroligins", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-XTR-9013408:r:RHOG GTPase cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-DME-6794361:r:Neurexins and neuroligins", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-6794361:r:Neurexins and neuroligins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR014776": {"description": "Tetrapyrrole methylase, subdomain 2", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "4pyrrole_Mease_sub2", "pathway_ids": ["R-SPO-5358493", "R-SCE-5358493", "R-BTA-5358493", "R-DDI-5358493", "R-HSA-5358493", "R-MMU-5358493"], "pathways": ["R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Homologous_superfamily"}, "IPR014777": {"description": "Tetrapyrrole methylase, subdomain 1", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "4pyrrole_Mease_sub1", "pathway_ids": ["R-SPO-5358493", "R-SCE-5358493", "R-BTA-5358493", "R-DDI-5358493", "R-HSA-5358493", "R-MMU-5358493"], "pathways": ["R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Homologous_superfamily"}, "IPR014780": {"description": "tRNA pseudouridine synthase II, TruB", "go_ids": ["GO:0001522", "GO:0003723", "GO:0009451", "GO:0009982"], "go_terms": ["GO:0001522:pseudouridine synthesis:P", "GO:0003723:RNA binding:F", "GO:0009451:RNA modification:P", "GO:0009982:pseudouridine synthase activity:F"], "name": "tRNA_psdUridine_synth_TruB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014781": {"description": "Anthrax toxin, lethal/endema factor, N-/C-terminal", "go_ids": [], "go_terms": [], "name": "Anthrax_toxin_lethal/edema_N/C", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Domain"}, "IPR014782": {"description": "Peptidase M1, membrane alanine aminopeptidase", "go_ids": ["GO:0008237", "GO:0008270"], "go_terms": ["GO:0008237:metallopeptidase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Peptidase_M1_dom", "pathway_ids": ["R-SSC-2022377", "R-HSA-6798695", "R-HSA-2142691", "R-SPO-2142691", "R-CEL-73779", "R-HSA-9018676", "R-SCE-9020265", "R-CEL-6798695", "R-RNO-9023661", "R-DME-76042", "R-BTA-6798695", "R-SCE-9018896", "R-RNO-9020265", "R-CEL-9020265", "R-CEL-9018681", "R-CEL-9023661", "R-SPO-9018896", "R-DDI-9020265", "R-HSA-9023661", "R-HSA-9018896", "R-SCE-2142691", "R-CEL-75953", "R-DME-75953", "R-CEL-73776", "R-RNO-9018676", "R-CEL-76042", "R-MMU-2022377", "R-MMU-9018676", "R-DDI-6798695", "R-BTA-9018896", "R-DME-674695", "R-RNO-1236977", "R-SPO-9020265", "R-MMU-1236977", "R-HSA-2022377", "R-DME-6804756", "R-CEL-674695", "R-DDI-9018896", "R-CEL-9018896", "R-HSA-1445148", "R-MMU-983170", "R-MMU-2142691", "R-MMU-6798695", "R-DDI-9018676", "R-RNO-983168", "R-RNO-6798695", "R-RNO-9018896", "R-BTA-9018681", "R-MMU-9018896", "R-SPO-6798695", "R-RNO-983170", "R-HSA-9018681", "R-MMU-9018681", "R-CEL-983170", "R-SCE-6798695", "R-DME-73779", "R-SPO-9018681", "R-CEL-2142691", "R-CEL-983168", "R-MMU-9023661", "R-BTA-9020265", "R-DME-73776", "R-SCE-9023661", "R-DDI-2142691", "R-SPO-983168", "R-SCE-983168", "R-SCE-9018676", "R-BTA-9023661", "R-SCE-983170", "R-CEL-9018676", "R-HSA-9020265", "R-DDI-9018681", "R-RNO-2022377", "R-SPO-9018676", "R-HSA-983168", "R-HSA-1236977", "R-BTA-983170", "R-DDI-9023661", "R-HSA-983170", "R-RNO-2142691", "R-SPO-9023661", "R-MMU-9020265", "R-MMU-983168", "R-RNO-9018681", "R-CFA-6798695", "R-SCE-9018681", "R-BTA-9018676", "R-BTA-2142691"], "pathways": ["R-SSC-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9018676:r:Biosynthesis of D-series resolvins", "R-SCE-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-6798695:r:Neutrophil degranulation", "R-RNO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-6798695:r:Neutrophil degranulation", "R-SCE-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-9018681:r:Biosynthesis of protectins", "R-CEL-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SPO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DDI-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-HSA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-1236977:r:Endosomal/Vacuolar pathway", "R-SPO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-CEL-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-BTA-9018681:r:Biosynthesis of protectins", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9018681:r:Biosynthesis of protectins", "R-MMU-9018681:r:Biosynthesis of protectins", "R-CEL-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-9018681:r:Biosynthesis of protectins", "R-CEL-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-BTA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-DDI-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9018676:r:Biosynthesis of D-series resolvins", "R-BTA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-9018676:r:Biosynthesis of D-series resolvins", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-DDI-9018681:r:Biosynthesis of protectins", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-SPO-9018676:r:Biosynthesis of D-series resolvins", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DDI-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9018681:r:Biosynthesis of protectins", "R-CFA-6798695:r:Neutrophil degranulation", "R-SCE-9018681:r:Biosynthesis of protectins", "R-BTA-9018676:r:Biosynthesis of D-series resolvins", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "type": "Domain"}, "IPR014784": {"description": "Copper type II, ascorbate-dependent monooxygenase-like, C-terminal", "go_ids": ["GO:0016715"], "go_terms": ["GO:0016715:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen:F"], "name": "Cu2_ascorb_mOase-like_C", "pathway_ids": ["R-CFA-209905", "R-DME-209905", "R-HSA-209905", "R-RNO-209905", "R-MMU-209905"], "pathways": ["R-CFA-209905:r:Catecholamine biosynthesis", "R-DME-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-RNO-209905:r:Catecholamine biosynthesis", "R-MMU-209905:r:Catecholamine biosynthesis"], "type": "Homologous_superfamily"}, "IPR014786": {"description": "Anaphase-promoting complex subunit 2, C-terminal", "go_ids": [], "go_terms": [], "name": "ANAPC2_C", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-SPO-176408", "R-HSA-2467813", "R-MMU-2467813", "R-MMU-174154", "R-MMU-69017", "R-MMU-179409", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-CEL-983168", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-DDI-176409", "R-DDI-2559582", "R-DDI-2467813", "R-SPO-983168", "R-DDI-176412", "R-SCE-983168", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-68867", "R-DDI-174084", "R-MMU-176409", "R-SPO-2559582", "R-HSA-176409", "R-HSA-9687136", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-SPO-179409", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-DDI-174184", "R-MMU-141430", "R-HSA-69017", "R-DDI-141430", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-DDI-174178", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Domain"}, "IPR014787": {"description": "Phosphoserine phosphatase RsbU, N-terminal", "go_ids": [], "go_terms": [], "name": "PSer_Pase_RsbU_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014788": {"description": "Acetylcholinesterase, tetramerisation domain", "go_ids": [], "go_terms": [], "name": "AChE_tetra", "pathway_ids": ["R-HSA-1483191", "R-BTA-422085", "R-MMU-422085", "R-HSA-9749641", "R-MMU-9749641", "R-BTA-9749641", "R-HSA-422085", "R-HSA-112311"], "pathways": ["R-HSA-1483191:r:Synthesis of PC", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-9749641:r:Aspirin ADME", "R-BTA-9749641:r:Aspirin ADME", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-112311:r:Neurotransmitter clearance"], "type": "Domain"}, "IPR014789": {"description": "Poly(A)-specific ribonuclease, RNA-binding", "go_ids": ["GO:0003723", "GO:0004535", "GO:0005634", "GO:0005737", "GO:0006402", "GO:0046872"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0004535:poly(A)-specific ribonuclease activity:F", "GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C", "GO:0006402:mRNA catabolic process:P", "GO:0046872:metal ion binding:F"], "name": "PolyA-riboNase_RNA-binding", "pathway_ids": ["R-MMU-450604", "R-HSA-380994", "R-MMU-429947", "R-DRE-450604", "R-HSA-429947", "R-HSA-450604"], "pathways": ["R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-429947:r:Deadenylation of mRNA", "R-DRE-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA"], "type": "Domain"}, "IPR014790": {"description": "MutL, C-terminal, dimerisation", "go_ids": ["GO:0006298", "GO:0005524"], "go_terms": ["GO:0006298:mismatch repair:P", "GO:0005524:ATP binding:F"], "name": "MutL_C", "pathway_ids": ["R-GGA-5358565", "R-HSA-5545483", "R-SCE-5358565", "R-SPO-5358565", "R-HSA-912446", "R-HSA-5358606", "R-HSA-5358565", "R-DDI-5358565", "R-HSA-6796648", "R-MMU-5358565", "R-HSA-5632987"], "pathways": ["R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632987:r:Defective Mismatch Repair Associated With PMS2"], "type": "Domain"}, "IPR014791": {"description": "Baseplate structural protein Gp11", "go_ids": [], "go_terms": [], "name": "Baseplate_struct_Gp11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014792": {"description": "RsbS co-antagonist protein RsbRA N-terminal domain", "go_ids": [], "go_terms": [], "name": "RsbRA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014793": {"description": "Dissimilatory sulphite reductase D", "go_ids": [], "go_terms": [], "name": "DsrD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014794": {"description": "Sporulation protein SpoIIT", "go_ids": [], "go_terms": [], "name": "SpoIIT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014795": {"description": "Antitoxin TacA 1-like", "go_ids": [], "go_terms": [], "name": "TacA_1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014796": {"description": "Protein of unknown function DUF1780, putative endonuclease", "go_ids": [], "go_terms": [], "name": "DUF1780", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014797": {"description": "CAMSAP, CKK domain", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "CKK_CAMSAP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014798": {"description": "Protein Ocr", "go_ids": [], "go_terms": [], "name": "Ocr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014799": {"description": "Apx/Shrm Domain 2", "go_ids": [], "go_terms": [], "name": "ASD2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014800": {"description": "Apx/Shrm Domain 1", "go_ids": ["GO:0051015"], "go_terms": ["GO:0051015:actin filament binding:F"], "name": "ASD1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014801": {"description": "Mediator complex, subunit Med5, fungi", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med5_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014803": {"description": "DNA repair protein Nse5/Nse6", "go_ids": [], "go_terms": [], "name": "DNA_repair_Nse5/Nse6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014804": {"description": "Mitochondrial protein Pet20-like", "go_ids": ["GO:0005739"], "go_terms": ["GO:0005739:mitochondrion:C"], "name": "Pet20-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014805": {"description": "SKG6/TOS2-like", "go_ids": [], "go_terms": [], "name": "SKG6/TOS2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014806": {"description": "Ubiquitin-fold modifier-conjugating enzyme 1", "go_ids": ["GO:0061657", "GO:0071569"], "go_terms": ["GO:0061657:UFM1 conjugating enzyme activity:F", "GO:0071569:protein ufmylation:P"], "name": "Ufc1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014807": {"description": "Cytochrome c oxidase assembly factor 1", "go_ids": [], "go_terms": [], "name": "Coa1", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-HSA-6799198"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR014808": {"description": "DNA replication factor Dna2, N-terminal", "go_ids": [], "go_terms": [], "name": "DNA_replication_fac_Dna2_N", "pathway_ids": ["R-BTA-69473", "R-RNO-174437", "R-BTA-5685938", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-MMU-6804756", "R-BTA-174437", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-RNO-69166", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-174437", "R-BTA-6804756", "R-BTA-69166", "R-RNO-5685938", "R-BTA-5693616", "R-MMU-174437", "R-RNO-6804756", "R-BTA-5693579", "R-BTA-5693607", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-SPO-69166", "R-MMU-5693607", "R-HSA-9701192", "R-RNO-5693579", "R-BTA-5693568", "R-HSA-69473", "R-RNO-5693607", "R-HSA-9709603", "R-MMU-5685942", "R-HSA-69166", "R-RNO-69473", "R-RNO-5685942", "R-HSA-6804756", "R-HSA-9704331", "R-MMU-69166", "R-RNO-5693568", "R-BTA-5685942", "R-RNO-5693616", "R-HSA-5693554", "R-HSA-5693579"], "pathways": ["R-BTA-69473:r:G2/M DNA damage checkpoint", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange"], "type": "Domain"}, "IPR014810": {"description": "Fcf2 pre-rRNA processing, C-terminal", "go_ids": [], "go_terms": [], "name": "Fcf2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014811": {"description": "Argonaute, linker 1 domain", "go_ids": [], "go_terms": [], "name": "ArgoL1", "pathway_ids": ["R-HSA-8853884", "R-HSA-426486", "R-SPO-426496", "R-RNO-203927", "R-MMU-426496", "R-HSA-2559580", "R-HSA-9022692", "R-HSA-8936459", "R-HSA-5578749", "R-HSA-2559585", "R-HSA-8948700", "R-DME-5578749", "R-HSA-5628897", "R-HSA-1912408", "R-XTR-426496", "R-HSA-9764562", "R-DRE-426496", "R-SPO-5578749", "R-SPO-426486", "R-HSA-203927", "R-CEL-203927", "R-HSA-9759811", "R-HSA-4086398", "R-HSA-9824594", "R-HSA-9029569", "R-HSA-9018519", "R-HSA-5601884", "R-XTR-5578749", "R-CEL-426486", "R-MMU-5578749", "R-HSA-9839394", "R-HSA-8943723", "R-RNO-426496", "R-HSA-8934593", "R-RNO-5578749", "R-MMU-426486", "R-RNO-426486", "R-HSA-9725371", "R-MMU-203927", "R-HSA-9768778", "R-DME-203927", "R-HSA-5687128", "R-XTR-426486", "R-HSA-9820841", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-426496", "R-DME-426496", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-SPO-426496:r:Post-transcriptional silencing by small RNAs", "R-RNO-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-XTR-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-DRE-426496:r:Post-transcriptional silencing by small RNAs", "R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-XTR-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-RNO-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR014812": {"description": "Vacuolar protein sorting-associated protein 51", "go_ids": [], "go_terms": [], "name": "Vps51", "pathway_ids": ["R-DME-6811440", "R-HSA-6811440", "R-MMU-6811440"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR014813": {"description": "Guanine nucleotide-binding protein-like 3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Gnl3_N_dom", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DRE-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR014815": {"description": "Phospholipase C-beta, C-terminal domain", "go_ids": ["GO:0004435", "GO:0005509", "GO:0016042"], "go_terms": ["GO:0004435:phosphatidylinositol-4,5-bisphosphate phospholipase C activity:F", "GO:0005509:calcium ion binding:F", "GO:0016042:lipid catabolic process:P"], "name": "PLC-beta_C", "pathway_ids": ["PWY-6367", "PWY-7039", "PWY-6351", "PWY-8052", "R-MMU-416476", "R-BTA-112043", "R-MMU-4086398", "R-HSA-416476", "R-HSA-399997", "R-RNO-399997", "R-HSA-112043", "R-HSA-500657", "R-BTA-4086398", "R-HSA-4086398", "R-MMU-434316", "R-MMU-1855204", "R-RNO-416476", "R-RNO-434316", "R-HSA-434316", "R-HSA-418217", "R-MMU-112043", "R-MMU-500657", "R-BTA-434316", "R-BTA-399997", "R-RNO-112043", "R-BTA-500657", "R-BTA-416476", "R-BTA-1855204", "R-HSA-9717207", "R-MMU-418217", "R-HSA-1855204", "R-MMU-399997", "R-RNO-1855204", "R-BTA-418217"], "pathways": ["PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "R-MMU-416476:r:G alpha (q) signalling events", "R-BTA-112043:r:PLC beta mediated events", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-112043:r:PLC beta mediated events", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-4086398:r:Ca2+ pathway", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-MMU-112043:r:PLC beta mediated events", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-BTA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-BTA-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-112043:r:PLC beta mediated events", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-416476:r:G alpha (q) signalling events", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-418217:r:G beta:gamma signalling through PLC beta"], "type": "Domain"}, "IPR014816": {"description": "tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14", "go_ids": ["GO:0160107", "GO:0030488", "GO:0031515"], "go_terms": ["GO:0160107:tRNA (adenine(58)-N1)-methyltransferase activity:F", "GO:0030488:tRNA methylation:P", "GO:0031515:tRNA (m1A) methyltransferase complex:C"], "name": "tRNA_MeTrfase_Gcd14", "pathway_ids": ["PWY-6829", "R-HSA-6782315", "R-HSA-9937008", "R-HSA-6787450"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Family"}, "IPR014817": {"description": "Gag protein p6", "go_ids": [], "go_terms": [], "name": "Gag_p6", "pathway_ids": ["R-HSA-180910", "R-HSA-164516", "R-HSA-162585", "R-HSA-1169408", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-164525", "R-HSA-162594", "R-HSA-162592", "R-HSA-177539", "R-HSA-174490", "R-HSA-175567", "R-HSA-175474", "R-HSA-174495", "R-HSA-173107"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-174495:r:Synthesis And Processing Of GAG, GAGPOL Polyproteins", "R-HSA-173107:r:Binding and entry of HIV virion"], "type": "Domain"}, "IPR014818": {"description": "Bacteriophage/plasmid primase, P4, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage/plasmid_primase_P4_C", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR014819": {"description": "Primase, C-terminal 2", "go_ids": ["GO:0016817"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F"], "name": "PriCT_2", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR014820": {"description": "Primase, C-terminal 1", "go_ids": [], "go_terms": [], "name": "PriCT_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014821": {"description": "Inositol 1,4,5-trisphosphate/ryanodine receptor", "go_ids": [], "go_terms": [], "name": "Ins145_P3_rcpt", "pathway_ids": ["R-MMU-139853", "R-HSA-139853", "R-CEL-983695", "R-HSA-5607763", "R-HSA-2672351", "R-HSA-1489509", "R-HSA-2029485", "R-DME-114508", "R-MMU-418457", "R-MMU-381676", "R-RNO-2672351", "R-HSA-418457", "R-HSA-112043", "R-HSA-114508", "R-MMU-9717207", "R-MMU-2672351", "R-CEL-114508", "R-CEL-9717207", "R-RNO-139853", "R-DME-139853", "R-RNO-418457", "R-HSA-5578775", "R-HSA-4086398", "R-RNO-114508", "R-DME-381676", "R-MMU-114508", "R-HSA-983695", "R-RNO-9717207", "R-DME-5578775", "R-RNO-5578775", "R-CEL-139853", "R-HSA-2871809", "R-MMU-5578775", "R-DME-983695", "R-DME-9717207", "R-MMU-983695", "R-RNO-381676", "R-CEL-381676", "R-HSA-5218921", "R-HSA-9717207", "R-CEL-5578775", "R-HSA-381676", "R-RNO-983695", "R-HSA-9664323", "R-HSA-422356"], "pathways": ["R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-CEL-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-1489509:r:DAG and IP3 signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-MMU-418457:r:cGMP effects", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-418457:r:cGMP effects", "R-HSA-112043:r:PLC beta mediated events", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-MMU-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-2672351:r:Stimuli-sensing channels", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-CEL-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-DME-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-418457:r:cGMP effects", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-4086398:r:Ca2+ pathway", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-CEL-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5578775:r:Ion homeostasis", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-5578775:r:Ion homeostasis", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR014822": {"description": "Non-structural protein NSP9, coronavirus", "go_ids": ["GO:0003723", "GO:0019079"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0019079:viral genome replication:P"], "name": "NSP9_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR014824": {"description": "Scaffold protein Nfu/NifU, N-terminal", "go_ids": [], "go_terms": [], "name": "Nfu/NifU_N", "pathway_ids": ["R-DME-9857492", "R-MMU-9857492", "R-SCE-9857492", "R-HSA-9857492"], "pathways": ["R-DME-9857492:r:Protein lipoylation", "R-MMU-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-HSA-9857492:r:Protein lipoylation"], "type": "Domain"}, "IPR014825": {"description": "DNA alkylation repair enzyme", "go_ids": [], "go_terms": [], "name": "DNA_alkylation", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014826": {"description": "Formaldehyde-activating enzyme", "go_ids": ["GO:0016051", "GO:0016840"], "go_terms": ["GO:0016051:carbohydrate biosynthetic process:P", "GO:0016840:carbon-nitrogen lyase activity:F"], "name": "HCHO-activating_enzyme", "pathway_ids": ["PWY-1861", "PWY-1723", "PWY-7796"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1723:t:formaldehyde oxidation VI (H4MPT pathway)", "PWY-7796:t:pentose phosphate pathway (oxidative branch) II"], "type": "Domain"}, "IPR014828": {"description": "Non-structural protein NSP7, coronavirus", "go_ids": [], "go_terms": [], "name": "NSP7_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR014829": {"description": "Non-structural protein NSP8, coronavirus", "go_ids": ["GO:0004197", "GO:0016740", "GO:0008242"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0016740:transferase activity:F", "GO:0008242:omega peptidase activity:F"], "name": "NSP8_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR014830": {"description": "Glycolipid transfer protein domain", "go_ids": ["GO:0005737", "GO:0120013", "GO:0120009"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0120013:lipid transfer activity:F", "GO:0120009:intermembrane lipid transfer:P"], "name": "Glycolipid_transfer_prot_dom", "pathway_ids": ["R-BTA-9845576", "R-BTA-1660499", "R-RNO-1660499", "R-HSA-9845576", "R-CFA-1660499", "R-RNO-9845576", "R-CFA-9845576", "R-MMU-9845576", "R-DRE-1660499", "R-HSA-1660499", "R-XTR-9845576", "R-DRE-9845576", "R-MMU-1660499"], "pathways": ["R-BTA-9845576:r:Glycosphingolipid transport", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9845576:r:Glycosphingolipid transport", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9845576:r:Glycosphingolipid transport", "R-CFA-9845576:r:Glycosphingolipid transport", "R-MMU-9845576:r:Glycosphingolipid transport", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-XTR-9845576:r:Glycosphingolipid transport", "R-DRE-9845576:r:Glycosphingolipid transport", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Domain"}, "IPR014831": {"description": "Haemagglutinin stalk, influenza C", "go_ids": ["GO:0019031", "GO:0019064", "GO:0046789"], "go_terms": ["GO:0019031:viral envelope:C", "GO:0019064:fusion of virus membrane with host plasma membrane:P", "GO:0046789:host cell surface receptor binding:F"], "name": "Hemagglutn_stalk_influenz-C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014832": {"description": "TnsA endonuclease C-terminal", "go_ids": [], "go_terms": [], "name": "TnsA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014833": {"description": "TnsA endonuclease, N-terminal", "go_ids": [], "go_terms": [], "name": "TnsA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014834": {"description": "Gag protein p15", "go_ids": [], "go_terms": [], "name": "Gag_p15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014835": {"description": "NS1 nuclease, NS1-Nuc domain, parvovirinae", "go_ids": [], "go_terms": [], "name": "NS1-Nuc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014836": {"description": "Integrin beta subunit, cytoplasmic domain", "go_ids": [], "go_terms": [], "name": "Integrin_bsu_cyt_dom", "pathway_ids": ["R-DME-2173789", "R-HSA-8874081", "R-MMU-210991", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-MMU-9013408", "R-MMU-210990", "R-CEL-3000178", "R-HSA-9856532", "R-MMU-445355", "R-CEL-1566948", "R-DME-445355", "R-MMU-3000170", "R-CEL-446343", "R-RNO-9634597", "R-RNO-210990", "R-DME-446343", "R-MMU-202733", "R-CEL-198933", "R-HSA-8875513", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-6802955", "R-HSA-210991", "R-RNO-446343", "R-DME-9013149", "R-HSA-6802948", "R-DME-210991", "R-RNO-445144", "R-RNO-1566977", "R-BTA-1566948", "R-DME-114608", "R-MMU-9634597", "R-CEL-5674135", "R-HSA-9609690", "R-HSA-447041", "R-DME-216083", "R-MMU-9013423", "R-MMU-216083", "R-HSA-445144", "R-MMU-354192", "R-MMU-9860927", "R-HSA-9656223", "R-HSA-9634597", "R-MMU-5674135", "R-RNO-216083", "R-RNO-9860927", "R-HSA-9013423", "R-RNO-8874081", "R-HSA-114608", "R-MMU-8874081", "R-RNO-354192", "R-CEL-354192", "R-RNO-5674135", "R-BTA-2129379", "R-RNO-2173789", "R-CEL-9013423", "R-MMU-3000157", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-3000170", "R-MMU-1566977", "R-DME-202733", "R-DME-6798695", "R-DME-446107", "R-MMU-354194", "R-MMU-1236973", "R-RNO-9013423", "R-CEL-445355", "R-HSA-5663220", "R-MMU-9013149", "R-RNO-3000170", "R-BTA-216083", "R-HSA-202733", "R-HSA-6798695", "R-HSA-5674135", "R-HSA-166016", "R-DME-198933", "R-CEL-6798695", "R-CEL-354194", "R-BTA-6798695", "R-RNO-3000157", "R-RNO-9013149", "R-MMU-4420097", "R-MMU-9013404", "R-HSA-9927418", "R-BTA-2173789", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-HSA-446343", "R-RNO-202733", "R-CEL-202733", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-3000178", "R-HSA-2173789", "R-CEL-216083", "R-BTA-198933", "R-CEL-9860927", "R-RNO-198933", "R-CEL-1236973", "R-MMU-166016", "R-CEL-114608", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-RNO-1566948", "R-DME-354192", "R-BTA-166016", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-75892", "R-MMU-198933", "R-DME-445144", "R-HSA-198933", "R-MMU-8875513", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-372708", "R-RNO-4420097", "R-MMU-114608", "R-HSA-9725554", "R-HSA-3000157", "R-CEL-1566977", "R-BTA-3000178", "R-HSA-1566948", "R-DME-9860927", "R-RNO-354194", "R-RNO-2129379", "R-CEL-9013149", "R-RNO-114608", "R-BTA-202733", "R-MMU-372708", "R-HSA-210990", "R-RNO-8875513", "R-DME-1236973", "R-HSA-416700", "R-HSA-6802946", "R-DME-2129379", "R-HSA-9938206", "R-MMU-446343", "R-HSA-354192", "R-CEL-210991", "R-HSA-216083", "R-HSA-445355", "R-RNO-210991", "R-CEL-445144", "R-HSA-1566977", "R-HSA-9927432", "R-HSA-354194", "R-HSA-9679191", "R-HSA-9830674", "R-DME-3000170", "R-CEL-4420097", "R-DME-9013423", "R-MMU-2129379"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-445355:r:Smooth Muscle Contraction", "R-CEL-1566948:r:Elastic fibre formation", "R-DME-445355:r:Smooth Muscle Contraction", "R-MMU-3000170:r:Syndecan interactions", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-9634597:r:GPER1 signaling", "R-RNO-210990:r:PECAM1 interactions", "R-DME-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-210991:r:Basigin interactions", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-1566977:r:Fibronectin matrix formation", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-447041:r:CHL1 interactions", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000157:r:Laminin interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-1566948:r:Elastic fibre formation", "R-DME-354192:r:Integrin signaling", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-CEL-1566977:r:Fibronectin matrix formation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-1566948:r:Elastic fibre formation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-354192:r:Integrin signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-210991:r:Basigin interactions", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR014837": {"description": "EF-hand, Ca insensitive", "go_ids": [], "go_terms": [], "name": "EF-hand_Ca_insen", "pathway_ids": ["R-SPO-6807878", "R-HSA-9013405", "R-HSA-6798695", "R-RNO-445095", "R-GGA-9035034", "R-HSA-9013418", "R-DME-375165", "R-GGA-446388", "R-BTA-5673001", "R-RNO-446388", "R-HSA-9013424", "R-DDI-114608", "R-MMU-446388", "R-HSA-442982", "R-BTA-9035034", "R-DME-9035034", "R-MMU-9013420", "R-RNO-9013424", "R-HSA-9662360", "R-DME-264870", "R-BTA-438066", "R-RNO-375165", "R-BTA-9013418", "R-DME-6807878", "R-RNO-5673001", "R-MMU-5673001", "R-DME-438066", "R-HSA-373753", "R-DDI-6798695", "R-DME-445095", "R-MMU-9035034", "R-DME-114608", "R-MMU-438066", "R-MMU-390522", "R-GGA-9013418", "R-BTA-390522", "R-HSA-5673001", "R-DME-446388", "R-MMU-445095", "R-HSA-9620244", "R-SPO-9013424", "R-MMU-6798695", "R-HSA-264870", "R-RNO-9013420", "R-MMU-9013418", "R-HSA-9609736", "R-DDI-9013418", "R-RNO-6798695", "R-MMU-114608", "R-MMU-375165", "R-SPO-6798695", "R-DME-5673001", "R-HSA-445095", "R-RNO-9035034", "R-MMU-6807878", "R-DME-9013424", "R-HSA-375165", "R-SPO-114608", "R-RNO-114608", "R-HSA-114608", "R-BTA-114608", "R-HSA-9035034", "R-SPO-9013420", "R-HSA-9617324", "R-RNO-9013418", "R-HSA-9013420", "R-HSA-3000170", "R-RNO-6807878", "R-DME-6798695", "R-HSA-9662361", "R-HSA-6807878", "R-MMU-9013424", "R-BTA-446388", "R-GGA-114608", "R-DME-9013418", "R-HSA-438066", "R-DDI-6807878", "R-MMU-264870", "R-HSA-390522", "R-RNO-264870", "R-HSA-446388", "R-DME-9013420"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-GGA-9035034:r:RHOF GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DDI-114608:r:Platelet degranulation", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-BTA-9035034:r:RHOF GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-373753:r:Nephrin family interactions", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-445095:r:Interaction between L1 and Ankyrins", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-114608:r:Platelet degranulation", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-390522:r:Striated Muscle Contraction", "R-GGA-9013418:r:RHOBTB2 GTPase cycle", "R-BTA-390522:r:Striated Muscle Contraction", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-HSA-9620244:r:Long-term potentiation", "R-SPO-9013424:r:RHOV GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-3000170:r:Syndecan interactions", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-9013424:r:RHOV GTPase cycle", "R-BTA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-GGA-114608:r:Platelet degranulation", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR014838": {"description": "Poliovirus 3A protein-like", "go_ids": ["GO:0004197", "GO:0017111", "GO:0003968"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0017111:ribonucleoside triphosphate phosphatase activity:F", "GO:0003968:RNA-directed RNA polymerase activity:F"], "name": "P3A", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR014839": {"description": "Ribonucleotide reductase, transcriptional regulator Crt10", "go_ids": [], "go_terms": [], "name": "Crt10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014840": {"description": "Hpc2-related domain", "go_ids": [], "go_terms": [], "name": "HRD", "pathway_ids": ["R-SCE-2559584", "R-MMU-2559584", "R-HSA-2559584"], "pathways": ["R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Domain"}, "IPR014841": {"description": "Rad33", "go_ids": [], "go_terms": [], "name": "Rad33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014842": {"description": "Iron-regulated transcriptional activator AFT", "go_ids": ["GO:0010106", "GO:0045944", "GO:0000981"], "go_terms": ["GO:0010106:cellular response to iron ion starvation:P", "GO:0045944:positive regulation of transcription by RNA polymerase II:P", "GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific:F"], "name": "AFT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014843": {"description": "Protein Him1/Fmp52", "go_ids": [], "go_terms": [], "name": "Him1/Fmp52", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014844": {"description": "PalH/RIM21", "go_ids": [], "go_terms": [], "name": "PalH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014845": {"description": "Protein GYD/TTHA1554", "go_ids": [], "go_terms": [], "name": "GYD/TTHA1554", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014846": {"description": "Protein of unknown function DUF1786, putative pyruvate format-lyase activating enzyme", "go_ids": [], "go_terms": [], "name": "DUF1786_pyruvate_format-lyase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014847": {"description": "FERM adjacent", "go_ids": [], "go_terms": [], "name": "FA", "pathway_ids": ["R-MMU-9035034", "R-HSA-399719", "R-CEL-5675221", "R-MMU-166016", "R-RNO-9035034", "R-MMU-8980692", "R-HSA-166016", "R-RNO-8980692", "R-MMU-6794361", "R-MMU-399955", "R-HSA-9662361", "R-RNO-9013149", "R-RNO-9013148", "R-MMU-9013148", "R-RNO-399719", "R-HSA-6794361", "R-HSA-9008059", "R-HSA-9013149", "R-HSA-8980692", "R-BTA-6794361", "R-HSA-9662360", "R-HSA-9035034", "R-HSA-9013148", "R-HSA-399955", "R-HSA-9022699", "R-DME-6794361", "R-CFA-6794361", "R-RNO-6794361", "R-MMU-9013149", "R-CEL-182971", "R-MMU-399719"], "pathways": ["R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-6794361:r:Neurexins and neuroligins", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-DME-6794361:r:Neurexins and neuroligins", "R-CFA-6794361:r:Neurexins and neuroligins", "R-RNO-6794361:r:Neurexins and neuroligins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-182971:r:EGFR downregulation", "R-MMU-399719:r:Trafficking of AMPA receptors"], "type": "Domain"}, "IPR014848": {"description": "Reduced growth phenotype protein 1", "go_ids": [], "go_terms": [], "name": "Rgp1", "pathway_ids": ["R-SCE-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-MMU-8876198", "R-HSA-6811440", "R-HSA-8876198", "R-SPO-6811440", "R-SPO-8876198", "R-SCE-8876198", "R-MMU-6811440"], "pathways": ["R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR014849": {"description": "EKC/KEOPS complex, subunit Gon7", "go_ids": [], "go_terms": [], "name": "EKC/KEOPS_Gon7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014851": {"description": "BCS1, N-terminal", "go_ids": [], "go_terms": [], "name": "BCS1_N", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-1268020", "R-HSA-9865881"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR014852": {"description": "Uncharacterised protein YwhD", "go_ids": [], "go_terms": [], "name": "YwhD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014853": {"description": "VWF/SSPO/Zonadhesin-like, cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "VWF/SSPO/ZAN-like_Cys-rich_dom", "pathway_ids": ["R-HSA-5083632", "R-MMU-163125", "R-HSA-5674135", "R-MMU-5674135", "R-HSA-6802952", "R-HSA-9845620", "R-HSA-977068", "R-MMU-913709", "R-HSA-140837", "R-HSA-430116", "R-MMU-76009", "R-MMU-430116", "R-HSA-9845622", "R-HSA-9845621", "R-MMU-372708", "R-HSA-114608", "R-HSA-76009", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-9846298", "R-HSA-5083625", "R-HSA-9672391", "R-MMU-977068", "R-HSA-5621480", "R-HSA-6802955", "R-HSA-9672393", "R-HSA-354192", "R-HSA-5083636", "R-HSA-6802948", "R-HSA-216083", "R-HSA-5083635", "R-HSA-9662361", "R-MMU-140837", "R-HSA-9845619", "R-HSA-354194", "R-MMU-354194", "R-HSA-163125", "R-HSA-75892", "R-RNO-5173214", "R-MMU-114608", "R-HSA-5173214", "R-MMU-5173214", "R-MMU-216083", "R-HSA-372708", "R-MMU-354192", "R-HSA-913709", "R-HSA-9656223"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-354192:r:Integrin signaling", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-114608:r:Platelet degranulation", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Domain"}, "IPR014854": {"description": "Non-structural maintenance of chromosome element 4, C-terminal", "go_ids": [], "go_terms": [], "name": "Nse4_C", "pathway_ids": ["R-SCE-3108214", "R-MMU-3108214", "R-SPO-3108214", "R-BTA-3108214", "R-RNO-3108214", "R-HSA-3108214"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Domain"}, "IPR014855": {"description": "Plant transcription factor NOZZLE", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "NOZZLE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014856": {"description": "RNA-free ribonuclease P", "go_ids": [], "go_terms": [], "name": "RNA_free_RNase_P", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014857": {"description": "Non-structural maintenance of chromosomes element 1, RING C4HC3-type", "go_ids": [], "go_terms": [], "name": "Nse1_RING_C4HC3-type", "pathway_ids": ["PWY-7511", "R-SCE-3108214", "R-DRE-3108214", "R-MMU-3108214", "R-SPO-3108214", "R-RNO-3108214", "R-HSA-3108214"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Domain"}, "IPR014858": {"description": "BREX protein BrxB", "go_ids": [], "go_terms": [], "name": "BrxB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014859": {"description": "Phage tail assembly chaperone", "go_ids": [], "go_terms": [], "name": "Phage_TAC_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014861": {"description": "CNP1-like, uncharacterised domain", "go_ids": [], "go_terms": [], "name": "CNP1-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014862": {"description": "TrwC relaxase", "go_ids": [], "go_terms": [], "name": "TrwC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014864": {"description": "Transcription factor, NikR, nickel binding C-terminal", "go_ids": [], "go_terms": [], "name": "TF_NikR_Ni-bd_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014866": {"description": "YfkB-like domain", "go_ids": [], "go_terms": [], "name": "YfkB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014867": {"description": "Spore coat protein CotH/Invasin CotH2/3/7", "go_ids": [], "go_terms": [], "name": "Spore_coat_CotH_CotH2/3/7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014868": {"description": "Cadherin prodomain", "go_ids": [], "go_terms": [], "name": "Cadherin_pro_dom", "pathway_ids": ["R-HSA-6798695", "R-DRE-525793", "R-HSA-6809371", "R-DRE-9768727", "R-RNO-216083", "R-HSA-5626467", "R-DRE-1474228", "R-RNO-1474228", "R-RNO-418990", "R-RNO-351906", "R-HSA-9766229", "R-HSA-351906", "R-HSA-9927418", "R-CFA-216083", "R-MMU-8957275", "R-RNO-525793", "R-HSA-9764562", "R-HSA-418990", "R-CFA-9768727", "R-HSA-9764561", "R-DRE-5626467", "R-MMU-9764561", "R-DRE-6798695", "R-HSA-9823730", "R-MMU-381426", "R-RNO-8957275", "R-GGA-8957275", "R-HSA-9926550", "R-CFA-418990", "R-DRE-418990", "R-HSA-9938206", "R-RNO-9768727", "R-GGA-381426", "R-HSA-525793", "R-HSA-381426", "R-HSA-6805567", "R-DRE-8957275", "R-MMU-1474228", "R-HSA-1474228", "R-CFA-9766229", "R-RNO-9764561", "R-MMU-5626467", "R-HSA-216083", "R-CFA-351906", "R-GGA-418990", "R-DRE-6805567", "R-DRE-9764561", "R-HSA-9927432", "R-DRE-6809371", "R-RNO-5626467", "R-MMU-351906", "R-CFA-9764561", "R-GGA-525793", "R-MMU-418990", "R-HSA-8876493", "R-RNO-381426", "R-DRE-9766229", "R-MMU-6809371", "R-CFA-1474228", "R-DRE-381426", "R-RNO-9766229", "R-MMU-216083", "R-HSA-198933", "R-HSA-9856649", "R-MMU-525793", "R-MMU-6798695", "R-HSA-8957275", "R-DRE-351906", "R-HSA-9768727", "R-MMU-9768727", "R-MMU-9766229", "R-MMU-6805567"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-525793:r:Myogenesis", "R-HSA-6809371:r:Formation of the cornified envelope", "R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-RNO-418990:r:Adherens junctions interactions", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9766229:r:Degradation of CDH1", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-CFA-216083:r:Integrin cell surface interactions", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-525793:r:Myogenesis", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-418990:r:Adherens junctions interactions", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9764561:r:Regulation of CDH1 Function", "R-DRE-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-9764561:r:Regulation of CDH1 Function", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9823730:r:Formation of definitive endoderm", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CFA-418990:r:Adherens junctions interactions", "R-DRE-418990:r:Adherens junctions interactions", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-525793:r:Myogenesis", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6805567:r:Keratinization", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-CFA-9766229:r:Degradation of CDH1", "R-RNO-9764561:r:Regulation of CDH1 Function", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-216083:r:Integrin cell surface interactions", "R-CFA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-GGA-418990:r:Adherens junctions interactions", "R-DRE-6805567:r:Keratinization", "R-DRE-9764561:r:Regulation of CDH1 Function", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-DRE-6809371:r:Formation of the cornified envelope", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-CFA-9764561:r:Regulation of CDH1 Function", "R-GGA-525793:r:Myogenesis", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-9766229:r:Degradation of CDH1", "R-MMU-6809371:r:Formation of the cornified envelope", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-9766229:r:Degradation of CDH1", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-525793:r:Myogenesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-6805567:r:Keratinization"], "type": "Domain"}, "IPR014869": {"description": "Glycosyltransferase GT-D fold", "go_ids": [], "go_terms": [], "name": "GT-D", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014871": {"description": "dUTPase/dCTP pyrophosphatase", "go_ids": [], "go_terms": [], "name": "dUTPase/dCTP_pyrophosphatase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014872": {"description": "Dicistrovirus, capsid-polyprotein, C-terminal", "go_ids": [], "go_terms": [], "name": "Dicistrovirus_capsid-polyPr_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014873": {"description": "Voltage-dependent calcium channel, alpha-1 subunit, IQ domain", "go_ids": [], "go_terms": [], "name": "VDCC_a1su_IQ", "pathway_ids": ["R-DME-5576893", "R-RNO-5576893", "R-GGA-422356", "R-DME-422356", "R-MMU-422356", "R-RNO-112308", "R-MMU-5576892", "R-HSA-400042", "R-HSA-5576892", "R-HSA-419037", "R-RNO-422356", "R-MMU-5576893", "R-HSA-9662360", "R-HSA-5576893", "R-DME-5576892", "R-HSA-112308", "R-MMU-112308", "R-RNO-5576892", "R-HSA-422356"], "pathways": ["R-DME-5576893:r:Phase 2 - plateau phase", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-GGA-422356:r:Regulation of insulin secretion", "R-DME-422356:r:Regulation of insulin secretion", "R-MMU-422356:r:Regulation of insulin secretion", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-422356:r:Regulation of insulin secretion", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-DME-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR014874": {"description": "Staphylocoagulase, N-terminal, subdomain 1", "go_ids": [], "go_terms": [], "name": "Staphylocoagulase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014875": {"description": "Mor transcription activator", "go_ids": [], "go_terms": [], "name": "Mor_transcription_activator", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014876": {"description": "DEK, C-terminal", "go_ids": [], "go_terms": [], "name": "DEK_C", "pathway_ids": ["R-HSA-9616222", "R-RNO-5250924", "R-MMU-5250924", "R-MMU-8864260", "R-HSA-8864260", "R-RNO-8864260", "R-HSA-5250924"], "pathways": ["R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-HSA-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-RNO-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression"], "type": "Domain"}, "IPR014877": {"description": "Exportin-1, C-terminal", "go_ids": ["GO:0005049"], "go_terms": ["GO:0005049:nuclear export signal receptor activity:F"], "name": "XPO1_C_dom", "pathway_ids": ["R-MMU-9856649", "R-DME-69273", "R-DME-9634638", "R-HSA-2467813", "R-HSA-3769402", "R-SPO-5687128", "R-DME-9707616", "R-RNO-2500257", "R-MMU-2467813", "R-SCE-9856649", "R-HSA-69273", "R-RNO-450520", "R-RNO-5687128", "R-MMU-68877", "R-RNO-9634638", "R-HSA-168333", "R-HSA-9828806", "R-HSA-68877", "R-MMU-9707616", "R-HSA-165054", "R-RNO-9707616", "R-RNO-141444", "R-MMU-9648025", "R-MMU-2500257", "R-MMU-3769402", "R-RNO-68877", "R-HSA-2500257", "R-DDI-5687128", "R-MMU-141444", "R-RNO-9856649", "R-HSA-9918432", "R-DME-9856649", "R-HSA-141444", "R-HSA-450520", "R-HSA-9707616", "R-MMU-450520", "R-HSA-9648025", "R-DME-450520", "R-HSA-9634638", "R-RNO-5663220", "R-RNO-69273", "R-DME-3769402", "R-HSA-5687128", "R-HSA-9856649", "R-HSA-5663220", "R-MMU-9634638", "R-MMU-5687128", "R-SCE-5687128", "R-MMU-69273", "R-HSA-2173788", "R-RNO-9648025", "R-RNO-2467813", "R-RNO-3769402", "R-MMU-5663220", "R-HSA-9768919"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-DME-9707616:r:Heme signaling", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-9707616:r:Heme signaling", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-9707616:r:Heme signaling", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9707616:r:Heme signaling", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Domain"}, "IPR014878": {"description": "THAP4-like, heme-binding domain", "go_ids": [], "go_terms": [], "name": "THAP4-like_heme-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014879": {"description": "Sporulation initiation factor Spo0A, C-terminal", "go_ids": ["GO:0003700", "GO:0005509", "GO:0005737", "GO:0006355", "GO:0042173"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0005509:calcium ion binding:F", "GO:0005737:cytoplasm:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0042173:regulation of sporulation resulting in formation of a cellular spore:P"], "name": "Spo0A_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014880": {"description": "Sulphur oxidation protein SoxZ", "go_ids": [], "go_terms": [], "name": "SoxZ_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014881": {"description": "Nin one binding (NOB1), Zn-ribbon-like domain", "go_ids": [], "go_terms": [], "name": "NOB1_Zn-bd", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR014882": {"description": "Cathepsin C exclusion", "go_ids": [], "go_terms": [], "name": "CathepsinC_exc", "pathway_ids": ["R-HSA-204005", "R-HSA-6798695", "R-MMU-204005", "R-RNO-2132295", "R-HSA-2132295", "R-RNO-5694530", "R-MMU-2132295", "R-MMU-5694530", "R-HSA-5694530", "R-MMU-6798695", "R-RNO-204005", "R-RNO-6798695"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-5694530:r:Cargo concentration in the ER", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR014883": {"description": "VRR-NUC domain", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "VRR_NUC", "pathway_ids": ["R-MMU-6783310", "R-HSA-6783310", "R-DRE-6783310"], "pathways": ["R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR014884": {"description": "Virulence regulon transcriptional activator VirB/ParB", "go_ids": [], "go_terms": [], "name": "VirB/ParB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014885": {"description": "VASP tetramerisation", "go_ids": [], "go_terms": [], "name": "VASP_tetra", "pathway_ids": ["R-MMU-446353", "R-MMU-376176", "R-HSA-446353", "R-HSA-202433", "R-DDI-5658442", "R-HSA-376176", "R-HSA-5663220", "R-DDI-446353", "R-DME-446353", "R-RNO-5663220", "R-MMU-5663220"], "pathways": ["R-MMU-446353:r:Cell-extracellular matrix interactions", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-HSA-202433:r:Generation of second messenger molecules", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DDI-446353:r:Cell-extracellular matrix interactions", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR014886": {"description": "La protein, xRRM domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "La_xRRM", "pathway_ids": ["R-HSA-73980", "R-HSA-749476"], "pathways": ["R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation"], "type": "Domain"}, "IPR014887": {"description": "HIF-1 alpha, C-terminal transactivation domain", "go_ids": [], "go_terms": [], "name": "HIF-1_CTAD", "pathway_ids": ["R-MMU-1234174", "R-RNO-1234176", "R-HSA-1234174", "R-HSA-1234158", "R-HSA-8951664", "R-HSA-5689880", "R-RNO-1234174", "R-HSA-452723", "R-HSA-6785807", "R-MMU-1234176", "R-RNO-5689880", "R-MMU-8951664", "R-MMU-1234158", "R-MMU-5689880", "R-HSA-9909649", "R-RNO-8951664", "R-HSA-8849473", "R-RNO-1234158", "R-HSA-2122947", "R-RNO-8857538", "R-HSA-9701898", "R-MMU-8857538", "R-HSA-8857538", "R-HSA-9664873", "R-HSA-1234176"], "pathways": ["R-MMU-1234174:r:Cellular response to hypoxia", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1234174:r:Cellular response to hypoxia", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-1234174:r:Cellular response to hypoxia", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-8951664:r:Neddylation", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-8951664:r:Neddylation", "R-HSA-8849473:r:PTK6 Expression", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9664873:r:Pexophagy", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Domain"}, "IPR014888": {"description": "Structural accessory protein ORF7a, SARS-CoV-like", "go_ids": [], "go_terms": [], "name": "ORF7a_SARS-CoV-like", "pathway_ids": ["R-HSA-9754560", "R-HSA-9679509", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9692916", "R-HSA-166662", "R-HSA-166663", "R-HSA-9727281", "R-HSA-9694614", "R-HSA-9694322", "R-HSA-9692913"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9727281:r:Translation of Accessory Proteins", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death"], "type": "Family"}, "IPR014889": {"description": "Transcription factor DP, C-terminal", "go_ids": [], "go_terms": [], "name": "Transc_factor_DP_C", "pathway_ids": ["R-MMU-8953750", "R-BTA-69231", "R-HSA-2559580", "R-HSA-69205", "R-DME-69231", "R-HSA-2559585", "R-HSA-69231", "R-HSA-8953750", "R-BTA-2173796", "R-HSA-139915", "R-HSA-1912408", "R-MMU-1538133", "R-HSA-69656", "R-CEL-1538133", "R-HSA-1538133", "R-DME-8953750", "R-HSA-9616222", "R-BTA-8953750", "R-CEL-69231", "R-HSA-2173796", "R-BTA-1538133", "R-HSA-113501", "R-HSA-9661069", "R-HSA-1362300", "R-MMU-2173796", "R-CEL-2173796", "R-DME-1538133", "R-HSA-1362277", "R-HSA-6804114", "R-HSA-111448", "R-DME-2173796", "R-CEL-8953750", "R-HSA-69202", "R-MMU-69231"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-69231:r:Cyclin D associated events in G1", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-69205:r:G1/S-Specific Transcription", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-1538133:r:G0 and Early G1", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-CEL-69231:r:Cyclin D associated events in G1", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-1538133:r:G0 and Early G1", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-1538133:r:G0 and Early G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Domain"}, "IPR014890": {"description": "c-SKI SMAD4-binding domain", "go_ids": ["GO:0046332"], "go_terms": ["GO:0046332:SMAD binding:F"], "name": "c-SKI_SMAD4-bd_dom", "pathway_ids": ["R-MMU-2173795", "R-HSA-201451", "R-HSA-2173795", "R-MMU-201451"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-201451:r:Signaling by BMP", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-201451:r:Signaling by BMP"], "type": "Domain"}, "IPR014891": {"description": "DWNN domain", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "DWNN_domain", "pathway_ids": ["PWY-7511", "R-SPO-9770562", "R-MMU-9013422", "R-HSA-9013422", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-983168", "R-SPO-983168", "R-SCE-983168", "R-HSA-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR014892": {"description": "Replication protein A, C-terminal", "go_ids": [], "go_terms": [], "name": "RPA_C", "pathway_ids": ["R-RNO-110312", "R-RNO-174437", "R-HSA-5693616", "R-SPO-5656169", "R-SPO-5656121", "R-HSA-5696397", "R-MMU-110320", "R-RNO-5655862", "R-MMU-6804756", "R-RNO-176187", "R-RNO-110314", "R-MMU-5685938", "R-HSA-5655862", "R-MMU-110314", "R-MMU-69473", "R-MMU-5696395", "R-SPO-5696395", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-RNO-5696397", "R-MMU-174437", "R-RNO-5656169", "R-HSA-5656121", "R-MMU-5358606", "R-MMU-5358565", "R-SPO-69166", "R-RNO-6782210", "R-SPO-176187", "R-RNO-5656121", "R-HSA-69473", "R-MMU-68962", "R-MMU-5651801", "R-RNO-5696395", "R-RNO-5693607", "R-HSA-110312", "R-HSA-6783310", "R-RNO-69473", "R-HSA-6804756", "R-SPO-110314", "R-HSA-5696395", "R-MMU-176187", "R-MMU-6782210", "R-MMU-5696397", "R-HSA-110314", "R-SCE-6782135", "R-SPO-5651801", "R-HSA-3371511", "R-RNO-68962", "R-RNO-3371453", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5655862", "R-HSA-5358606", "R-MMU-110312", "R-SPO-110312", "R-RNO-69166", "R-RNO-5685938", "R-HSA-912446", "R-HSA-68962", "R-HSA-6782210", "R-RNO-6804756", "R-HSA-5656169", "R-SCE-6782210", "R-SCE-176187", "R-HSA-5685938", "R-HSA-176187", "R-MMU-5696400", "R-MMU-5693607", "R-MMU-3371453", "R-MMU-5655862", "R-RNO-5358606", "R-SPO-5696397", "R-RNO-5358565", "R-RNO-6782135", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-HSA-69166", "R-RNO-110320", "R-SCE-68962", "R-MMU-6783310", "R-RNO-5685942", "R-MMU-5656121", "R-SPO-5696400", "R-SPO-110320", "R-SPO-6782210", "R-MMU-69166", "R-RNO-5696400", "R-HSA-5696400", "R-HSA-5358565", "R-SPO-68962", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-HSA-110320", "R-RNO-6783310"], "pathways": ["R-RNO-110312:r:Translesion synthesis by REV1", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-110312:r:Translesion synthesis by REV1", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-3371511:r:HSF1 activation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-RNO-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR014893": {"description": "Ku, C-terminal", "go_ids": [], "go_terms": [], "name": "Ku_PK_bind", "pathway_ids": ["R-HSA-3270619", "R-HSA-6798695", "R-HSA-5693571", "R-DDI-6798695", "R-SPO-6798695", "R-DDI-5693571", "R-HSA-1834949", "R-MMU-6798695", "R-MMU-5693571", "R-HSA-164843"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Domain"}, "IPR014894": {"description": "Inner membrane lipoprotein DcrB/EagT6", "go_ids": [], "go_terms": [], "name": "DcrB/EagT6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014895": {"description": "Alginate lyase 2", "go_ids": [], "go_terms": [], "name": "Alginate_lyase_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014896": {"description": "NHR2-like", "go_ids": [], "go_terms": [], "name": "NHR2", "pathway_ids": ["R-HSA-9827857"], "pathways": ["R-HSA-9827857:r:Specification of primordial germ cells"], "type": "Domain"}, "IPR014897": {"description": "PBCV-specific basic adaptor domain", "go_ids": [], "go_terms": [], "name": "PBCV_basic_adap", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014898": {"description": "Zinc finger, C2H2, LYAR-type", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_LYAR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014900": {"description": "Viral late gene transcription factor 3 , zinc ribbon", "go_ids": [], "go_terms": [], "name": "VLTF-3_Zn_ribbon", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014901": {"description": "2-cysteine adaptor", "go_ids": [], "go_terms": [], "name": "2-cysteine_adaptor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014902": {"description": "Factor H binding protein-like, C-terminal", "go_ids": [], "go_terms": [], "name": "FHBP-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014903": {"description": "Protein of unknown function DUF1796", "go_ids": [], "go_terms": [], "name": "DUF1796", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014904": {"description": "YkuJ-like", "go_ids": [], "go_terms": [], "name": "YkuJ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014905": {"description": "HIRAN domain", "go_ids": ["GO:0003676", "GO:0008270", "GO:0016818"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0008270:zinc ion binding:F", "GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F"], "name": "HIRAN", "pathway_ids": ["PWY-7250", "PWY-7511", "R-HSA-8866654", "R-MMU-8866654"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7511:t:protein ubiquitination", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Domain"}, "IPR014906": {"description": "Pre-mRNA processing factor 4 (PRP4)-like", "go_ids": [], "go_terms": [], "name": "PRP4-like", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR014907": {"description": "BT4734-like, N-terminal", "go_ids": [], "go_terms": [], "name": "BT4734-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014908": {"description": "Nucleoporin, Nup133/Nup155-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Nucleoporin_Nup133/Nup155_N", "pathway_ids": ["R-CEL-159231", "R-HSA-180910", "R-RNO-9615933", "R-DRE-3232142", "R-CEL-3301854", "R-CEL-159227", "R-RNO-3301854", "R-DRE-4551638", "R-MMU-4570464", "R-DME-4085377", "R-DRE-2467813", "R-DRE-141444", "R-HSA-170822", "R-RNO-3108214", "R-MMU-9615933", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-HSA-3371453", "R-RNO-191859", "R-CEL-159230", "R-CEL-4551638", "R-HSA-4570464", "R-DME-4615885", "R-DRE-5663220", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-DME-3371453", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-DME-159227", "R-HSA-168325", "R-MMU-170822", "R-HSA-9609690", "R-DRE-3371453", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-RNO-4085377", "R-SPO-4570464", "R-DRE-159227", "R-HSA-5619107", "R-RNO-4570464", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-SPO-159227", "R-SPO-159231", "R-DRE-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-HSA-1169408", "R-DRE-191859", "R-MMU-4615885", "R-HSA-159227", "R-DRE-3108214", "R-DRE-159236", "R-HSA-168333", "R-MMU-4085377", "R-HSA-165054", "R-CEL-3108214", "R-RNO-159236", "R-HSA-4615885", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-168276", "R-HSA-168271", "R-DRE-2500257", "R-SPO-4551638", "R-DME-4551638", "R-HSA-4085377", "R-RNO-159227", "R-CEL-9615933", "R-RNO-4551638", "R-DME-159230", "R-DRE-9615933", "R-DME-3301854", "R-RNO-170822", "R-DRE-3301854", "R-RNO-159231", "R-HSA-180746", "R-CEL-3371453", "R-CEL-159236"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-191859:r:snRNP Assembly", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159227:r:Transport of the SLBP independent Mature 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proteins", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180746:r:Nuclear import of Rev protein", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR014910": {"description": "Putative monooxygenase YdhR", "go_ids": [], "go_terms": [], "name": "YdhR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014911": {"description": "Type 4 secretion system, PilS, N-terminal", "go_ids": [], "go_terms": [], "name": "PilS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014912": {"description": "Selenoprotein F/M domain", "go_ids": [], "go_terms": [], "name": "Sep15_SelM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014913": {"description": "YppE-like", "go_ids": [], "go_terms": [], "name": "YppE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014914": {"description": "RES domain", "go_ids": [], "go_terms": [], "name": "RES_dom", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis"], "type": "Domain"}, "IPR014915": {"description": "Bacteriophage TLS, 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transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DRE-3214847:r:HATs acetylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene 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"R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DRE-3214847:r:HATs acetylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-DRE-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DRE-159418:r:Recycling of bile acids and salts", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-211976:r:Endogenous sterols", "R-RNO-211976:r:Endogenous sterols", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-159418:r:Recycling of bile acids and salts", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-211976:r:Endogenous sterols", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "type": "Domain"}, "IPR014936": {"description": "Axin beta-catenin binding", "go_ids": [], "go_terms": [], "name": "Axin_b-cat-bd", "pathway_ids": ["R-RNO-201681", "R-HSA-5358751", "R-DME-209155", "R-HSA-201681", "R-HSA-8939256", "R-RNO-4641262", "R-DRE-195253", "R-DME-432553", "R-HSA-5689880", "R-HSA-5467348", "R-DRE-4641257", "R-DME-195253", "R-HSA-196299", "R-DME-209214", "R-MMU-5689880", "R-RNO-4641257", "R-HSA-5358747", "R-RNO-196299", "R-DRE-4641262", "R-DME-209396", "R-DME-4641262", "R-HSA-5339716", "R-HSA-5467337", "R-HSA-4641257", "R-HSA-4641262", "R-HSA-9018519", "R-MMU-195253", "R-DME-209413", "R-HSA-195253", "R-HSA-5358752", "R-DME-209190", "R-HSA-5358749", "R-HSA-8931987", "R-MMU-196299", "R-DME-4641257", "R-DME-209360", "R-DME-209461", "R-MMU-201681", "R-DME-196299", "R-HSA-5467340", "R-RNO-5689880", "R-DRE-196299", "R-DME-209440", "R-MMU-4641257", "R-MMU-4641262", "R-HSA-4411364", "R-RNO-195253"], "pathways": ["R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-DRE-4641257:r:Degradation of AXIN", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-DME-209214:r:Phosphorylation of SMO", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-4641257:r:Degradation of AXIN", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-209396:r:Phosphorylation of ARM", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-DME-209190:r:Phosphorylation of CI", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-DME-4641257:r:Degradation of AXIN", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Domain"}, "IPR014937": {"description": "Protein of unknown function DUF1810", "go_ids": [], "go_terms": [], "name": "DUF1810", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014938": {"description": "YfhH-like", "go_ids": [], "go_terms": [], "name": "YfhH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014939": {"description": "CDT1 Geminin-binding domain-like", "go_ids": [], "go_terms": [], "name": "CDT1_Gemini-bd-like", "pathway_ids": ["R-MMU-68867", "R-HSA-68949", "R-HSA-69052", "R-HSA-69205", "R-MMU-68962", "R-HSA-68962", "R-SPO-68962", "R-MMU-68949", "R-SPO-68949", "R-MMU-69052", "R-HSA-68867"], "pathways": ["R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-SPO-68949:r:Orc1 removal from chromatin", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR014940": {"description": "BAAT/Acyl-CoA thioester hydrolase C-terminal", "go_ids": [], "go_terms": [], "name": "BAAT_C", "pathway_ids": ["PWY-7723", "PWY-6733", "PWY-1121", "PWY-321", "PWY-5996", "PWY-5972", "R-MMU-9837999", "R-MMU-193368", "R-HSA-9918432", "R-HSA-193368", "R-MMU-9033241", "R-RNO-9837999", "R-RNO-9033241", "R-MMU-159418", "R-RNO-159418", "R-RNO-77289", "R-HSA-390247", "R-MMU-77289", "R-RNO-193368", "R-MMU-390247", "R-HSA-159418", "R-HSA-9837999", "R-HSA-9033241", "R-HSA-77289"], "pathways": ["PWY-7723:t:bacterial bioluminescence", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-1121:t:suberin monomers biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-5996:t:oleate biosynthesis II (animals and fungi)", "PWY-5972:t:stearate biosynthesis I (animals)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-159418:r:Recycling of bile acids and salts", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation"], "type": "Domain"}, "IPR014941": {"description": "Fimbrium subunit FimB/Mfa2/Mfa3", "go_ids": [], "go_terms": [], "name": "FimB/Mfa2/Mfa3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014942": {"description": "Nucleotidyl transferase AbiEii toxin, Type IV TA system", "go_ids": [], "go_terms": [], "name": "AbiEii", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014943": {"description": "Protein of unknown function DUF1815", "go_ids": [], "go_terms": [], "name": "DUF1815", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014944": {"description": "Toxin SymE-like", "go_ids": ["GO:0003723", "GO:0005737", "GO:0016070", "GO:0016788"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005737:cytoplasm:C", "GO:0016070:RNA metabolic process:P", "GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "Toxin_SymE-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014945": {"description": "Protein of unknown function DUF1816", "go_ids": [], "go_terms": [], "name": "DUF1816", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014946": {"description": "Protein chlororespiratory reduction 6", "go_ids": [], "go_terms": [], "name": "CRR6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014947": {"description": "Protein of unknown function DUF1818", "go_ids": [], "go_terms": [], "name": "DUF1818", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014948": {"description": "BrxA", "go_ids": [], "go_terms": [], "name": "BrxA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014949": {"description": "Protein of unknown function DUF1820", "go_ids": [], "go_terms": [], "name": "DUF1820", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014951": {"description": "Protein of unknown function DUF1822", "go_ids": [], "go_terms": [], "name": "DUF1822", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014952": {"description": "Protein of unknown function DUF1823", "go_ids": [], "go_terms": [], "name": "DUF1823", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014953": {"description": "Protein of unknown function DUF1824", "go_ids": [], "go_terms": [], "name": "DUF1824", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014954": {"description": "Protein of unknown function DUF1825", "go_ids": [], "go_terms": [], "name": "DUF1825", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014955": {"description": "Protein of unknown function DUF1826", "go_ids": [], "go_terms": [], "name": "DUF1826", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014956": {"description": "Putative ParB-like nuclease", "go_ids": [], "go_terms": [], "name": "ParBc_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014957": {"description": "IDEAL domain", "go_ids": [], "go_terms": [], "name": "IDEAL_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014958": {"description": "DGC", "go_ids": [], "go_terms": [], "name": "DGC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014959": {"description": "Protein of unknown function DUF1827", "go_ids": [], "go_terms": [], "name": "DUF1827", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014960": {"description": "Domain of unknown function DUF1828", "go_ids": [], "go_terms": [], "name": "DUF1828", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014961": {"description": "Domain of unknown function DUF1829", "go_ids": [], "go_terms": [], "name": "DUF1829", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014962": {"description": "YolD-like protein", "go_ids": [], "go_terms": [], "name": "YolD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014963": {"description": "Peptidoglycan synthesis regulatory protein ReoY-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ReoY-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014964": {"description": "Protein of unknown function DUF1830", "go_ids": [], "go_terms": [], "name": "DUF1830", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014965": {"description": "Putative amino acid metabolism", "go_ids": [], "go_terms": [], "name": "Amino_acid_metab_prot_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014966": {"description": "FRG domain", "go_ids": [], "go_terms": [], "name": "FRG-dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014967": {"description": "Uncharacterised protein family, YugN-like", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YugN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014968": {"description": "XisI", "go_ids": [], "go_terms": [], "name": "XisI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014969": {"description": "DNA sulphur modification protein DndE", "go_ids": [], "go_terms": [], "name": "DNA_S_DndE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014971": {"description": "KGK", "go_ids": [], "go_terms": [], "name": "KGK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014972": {"description": "Bacteriophage Mu, Gp37", "go_ids": [], "go_terms": [], "name": "Phage_Mu_Gp37", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014973": {"description": "Domain of unknown function DUF1835", "go_ids": [], "go_terms": [], "name": "DUF1835", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014974": {"description": "Protein of unknown function DUF1833", "go_ids": [], "go_terms": [], "name": "DUF1833", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014975": {"description": "Protein of unknown function DUF1836", "go_ids": [], "go_terms": [], "name": "DUF1836", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014976": {"description": "Anti-bacteriophage protein A/HamA, nuclease domain", "go_ids": [], "go_terms": [], "name": "AbpA_HamA_nuclease", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014977": {"description": "WRC domain", "go_ids": [], "go_terms": [], "name": "WRC_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR014978": {"description": "Glutamine-Leucine-Glutamine, QLQ", "go_ids": ["GO:0005524", "GO:0005634", "GO:0006355"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Gln-Leu-Gln_QLQ", "pathway_ids": ["R-DME-9933947", "R-DME-9933946", "R-DME-8939243", "R-MMU-9933946", "R-MMU-1266695", "R-RNO-201722", "R-RNO-3214858", "R-MMU-9933937", "R-MMU-201722", "R-BTA-201722", "R-BTA-9764725", "R-HSA-9619665", "R-CEL-9934037", "R-BTA-9933946", "R-BTA-3247509", "R-DME-9934037", "R-HSA-3214858", "R-BTA-9933937", "R-HSA-9934037", "R-RNO-8939243", "R-BTA-3214858", "R-DME-9933939", "R-BTA-1266695", "R-DME-3214858", "R-DME-1266695", "R-HSA-9845323", "R-MMU-3247509", "R-DME-9764725", "R-DME-9933937", "R-BTA-9933939", "R-CEL-9933946", "R-RNO-9933939", "R-HSA-1266695", "R-RNO-9933946", "R-RNO-1266695", "R-MMU-9934037", "R-CEL-9933947", "R-CEL-9933937", "R-HSA-3247509", "R-HSA-9933947", "R-BTA-9933947", "R-HSA-9933939", "R-RNO-9934037", "R-HSA-9764725", "R-RNO-9933937", "R-RNO-9933947", "R-MMU-9764725", "R-HSA-9824585", "R-MMU-3214858", "R-MMU-8939243", "R-BTA-9934037", "R-MMU-9933939", "R-HSA-201722", "R-HSA-8939243", "R-RNO-9764725", "R-MMU-9933947", "R-CEL-9764725", "R-HSA-9933937", "R-CEL-3214858", "R-BTA-8939243", "R-DME-3247509", "R-HSA-9933946", "R-RNO-3247509", "R-CEL-9933939", "R-CEL-8939243"], "pathways": ["R-DME-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-1266695:r:Interleukin-7 signaling", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-BTA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-BTA-3247509:r:Chromatin modifying enzymes", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-DME-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-BTA-1266695:r:Interleukin-7 signaling", "R-DME-3214858:r:RMTs methylate histone arginines", "R-DME-1266695:r:Interleukin-7 signaling", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-RNO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-RNO-1266695:r:Interleukin-7 signaling", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-CEL-9933947:r:Formation of the non-canonical BAF 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nBAF)", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-3247509:r:Chromatin modifying enzymes", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-CEL-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR014980": {"description": "Dopa 4,5-dioxygenase", "go_ids": [], "go_terms": [], "name": "DOPA_dioxygen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR014981": {"description": "Flagellin D3", "go_ids": [], "go_terms": [], "name": "Flagellin_D3", "pathway_ids": ["R-GGA-433822", "R-HSA-975871", "R-GGA-977240", "R-GGA-451534", "R-HSA-168176", "R-HSA-5602680", "R-HSA-5603037", "R-HSA-844623"], "pathways": ["R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-GGA-977240:r:MyD88 cascade initiated on plasma membrane", "R-GGA-451534:r:TLR5 cascade", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR014982": {"description": "GSCFA", "go_ids": [], "go_terms": [], "name": "GSCFA", "pathway_ids": [], "pathways": [], "type": 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"R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Domain"}, "IPR015009": {"description": "Vinculin-binding site-containing domain", "go_ids": [], "go_terms": [], "name": "Vinculin-bd_dom", "pathway_ids": ["R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-9656223", "R-MMU-399955", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR015010": {"description": "TERF2-interacting telomeric protein 1, Myb domain", "go_ids": [], "go_terms": [], "name": "TERF2IP_Myb", "pathway_ids": ["R-BTA-174411", "R-MMU-174430", "R-RNO-174437", "R-HSA-174414", "R-MMU-174417", "R-BTA-174437", "R-XTR-171319", "R-BTA-174417", "R-HSA-1221632", "R-RNO-171319", "R-MMU-110331", "R-MMU-9670095", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-XTR-110330", "R-MMU-174414", "R-BTA-174430", "R-DRE-110331", "R-DRE-174430", "R-RNO-110330", "R-MMU-174437", "R-XTR-2559586", "R-HSA-110329", "R-HSA-110330", "R-BTA-110330", "R-RNO-174411", "R-BTA-9670095", "R-RNO-2559586", "R-MMU-110330", "R-HSA-171306", "R-DRE-110330", "R-MMU-2559586", "R-RNO-174430", "R-BTA-171306", "R-RNO-110331", "R-HSA-174430", "R-HSA-110328", "R-DRE-171319", "R-HSA-174411", "R-DRE-174437", "R-XTR-110331", "R-MMU-171319", "R-BTA-171319", "R-BTA-2559586", "R-XTR-171306", "R-HSA-9670095", "R-BTA-110331", "R-GGA-418124", "R-RNO-174417", "R-BTA-174414", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586", "R-RNO-174414"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-171319:r:Telomere Extension By Telomerase", "R-BTA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-1221632:r:Meiotic synapsis", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-XTR-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-DRE-110331:r:Cleavage of the damaged purine", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-BTA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-9670095:r:Inhibition of DNA recombination at telomere", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-DRE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-BTA-171306:r:Packaging Of Telomere Ends", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DRE-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-110331:r:Cleavage of the damaged purine", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-BTA-171319:r:Telomere Extension By Telomerase", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-XTR-171306:r:Packaging Of Telomere Ends", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-BTA-110331:r:Cleavage of the damaged purine", "R-GGA-418124:r:Telomere maintenance", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere"], "type": "Domain"}, "IPR015011": {"description": "Threonyl-tRNA synthetase, editing domain, archaea", "go_ids": ["GO:0004829", "GO:0005524", "GO:0005737", "GO:0008270"], "go_terms": ["GO:0004829:threonine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0008270:zinc ion binding:F"], "name": "Threonyl-tRNA_syn_edit_dom_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015012": {"description": "Phenylalanine zipper", "go_ids": [], "go_terms": [], "name": "Phe_ZIP", "pathway_ids": ["R-RNO-1170546", "R-MMU-1433559", "R-HSA-1433559", "R-MMU-1170546", "R-HSA-1170546", "R-RNO-983231", "R-HSA-983231", "R-MMU-982772", "R-MMU-9706369", "R-RNO-982772", "R-RNO-1433559", "R-MMU-983231", "R-HSA-2586552", "R-HSA-982772", "R-HSA-9706369"], "pathways": ["R-RNO-1170546:r:Prolactin receptor signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-982772:r:Growth hormone receptor signaling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-982772:r:Growth hormone receptor signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-9706369:r:Negative regulation of FLT3"], "type": "Domain"}, "IPR015013": {"description": "Transforming growth factor beta receptor 2 ectodomain", "go_ids": ["GO:0005026", "GO:0005524", "GO:0006468", "GO:0016020", "GO:0046872"], "go_terms": ["GO:0005026:transforming growth factor beta receptor activity, type II:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P", "GO:0016020:membrane:C", "GO:0046872:metal ion binding:F"], "name": "Transforming_GF_b_rcpt_2_ecto", "pathway_ids": ["R-HSA-3645790", "R-GGA-2173788", "R-MMU-2173789", "R-MMU-9839389", "R-GGA-2173789", "R-HSA-2173791", "R-HSA-3656535", "R-HSA-3304356", "R-MMU-2173791", "R-RNO-2173788", "R-HSA-3656532", "R-GGA-2173791", "R-RNO-2173791", "R-HSA-9839389", "R-GGA-9839389", "R-HSA-5689603", "R-HSA-3642279", "R-RNO-9839389", "R-MMU-2173788", "R-HSA-2173788", "R-RNO-2173789", "R-HSA-2173789"], "pathways": ["R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-GGA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-GGA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-5689603:r:UCH proteinases", "R-HSA-3642279:r:TGFBR2 MSI Frameshift Mutants in Cancer", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs"], "type": "Domain"}, "IPR015014": {"description": "PhoQ Sensor domain", "go_ids": ["GO:0000160", "GO:0004673", "GO:0005524", "GO:0016020", "GO:0018106", "GO:0046872"], "go_terms": ["GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0016020:membrane:C", "GO:0018106:peptidyl-histidine phosphorylation:P", "GO:0046872:metal ion binding:F"], "name": "PhoQ_Sensor", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Domain"}, "IPR015015": {"description": "F-actin binding", "go_ids": ["GO:0004715", "GO:0005524", "GO:0006468"], "go_terms": ["GO:0004715:non-membrane spanning protein tyrosine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P"], "name": "F-actin-binding", "pathway_ids": ["R-HSA-5663213", "R-DME-69231", "R-DME-5693565", "R-HSA-5693565", "R-DME-525793", "R-HSA-69231", "R-DME-9860927", "R-MMU-5685938", "R-HSA-9841922", "R-CEL-9013149", "R-MMU-5693565", "R-MMU-8939236", "R-HSA-8939236", "R-HSA-9013423", "R-DME-2029482", "R-MMU-5663213", "R-MMU-9841922", "R-DME-428890", "R-HSA-525793", "R-HSA-5685938", "R-CEL-525793", "R-DME-5663213", "R-CEL-9013423", "R-HSA-9706369", "R-DME-9013149", "R-CEL-9860927", "R-CEL-9841922", "R-MMU-428890", "R-HSA-983231", "R-DME-8939236", "R-MMU-9706369", "R-HSA-2029482", "R-CEL-5663213", "R-HSA-8940973", "R-MMU-2029482", "R-CEL-2029482", "R-CEL-8939236", "R-MMU-9013423", "R-HSA-9013149", "R-DME-9841922", "R-MMU-9013149", "R-MMU-525793", "R-HSA-9860927", "R-HSA-428890", "R-HSA-9664422", "R-DME-9013423", "R-MMU-9860927", "R-MMU-69231"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-69231:r:Cyclin D associated events in G1", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-525793:r:Myogenesis", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-525793:r:Myogenesis", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CEL-525793:r:Myogenesis", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-HSA-9706369:r:Negative regulation of FLT3", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-525793:r:Myogenesis", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Domain"}, "IPR015016": {"description": "Splicing factor 3B subunit 1", "go_ids": [], "go_terms": [], "name": "SF3b_su1", "pathway_ids": ["R-HSA-72163", "R-SPO-9770562", "R-MMU-5250924", "R-HSA-9770562", "R-MMU-72165", "R-MMU-9770562", "R-MMU-72163", "R-HSA-5250924", "R-HSA-72165", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR015017": {"description": "Protein of unknown function DUF1904", "go_ids": [], "go_terms": [], "name": "DUF1904", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015018": {"description": "Protein of unknown function DUF1905", "go_ids": [], "go_terms": [], "name": "DUF1905", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015019": {"description": "Ragulator complex protein LAMTOR3", "go_ids": ["GO:0032006"], "go_terms": ["GO:0032006:regulation of TOR signaling:P"], "name": "LAMTOR3", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-RNO-8943724", "R-MMU-5674135", "R-DRE-5674135", "R-HSA-5674135", "R-MMU-380972", "R-DDI-165159", "R-DME-5628897", "R-DRE-8943724", "R-MMU-1632852", "R-DRE-9639288", "R-MMU-9639288", "R-BTA-6798695", "R-DME-380972", "R-HSA-9639288", "R-HSA-5628897", "R-BTA-380972", "R-RNO-166208", "R-BTA-5674135", "R-HSA-166208", "R-RNO-1632852", "R-XTR-1632852", "R-DRE-166208", "R-DRE-6798695", "R-DME-166208", "R-XTR-166208", "R-XTR-5628897", "R-DRE-1632852", "R-MMU-5628897", "R-HSA-8943724", "R-RNO-5674135", "R-HSA-380972", "R-BTA-8943724", "R-RNO-165159", "R-DDI-6798695", "R-DDI-9639288", "R-DDI-5628897", "R-DME-5674135", "R-DDI-1632852", "R-BTA-166208", "R-MMU-165159", "R-DME-6798695", "R-RNO-5628897", "R-DDI-166208", "R-BTA-165159", "R-DDI-380972", "R-XTR-6798695", "R-BTA-5628897", "R-MMU-8943724", "R-BTA-1632852", "R-XTR-165159", "R-DDI-8943724", "R-DRE-165159", "R-DDI-5674135", "R-XTR-9639288", "R-RNO-380972", "R-MMU-166208", "R-HSA-1632852", "R-RNO-9639288", "R-MMU-6798695", "R-HSA-165159", "R-DME-1632852", "R-DME-165159", "R-XTR-380972", "R-DRE-380972", "R-DME-8943724", "R-BTA-9639288", "R-DRE-5628897", "R-DME-9639288"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DDI-165159:r:MTOR signalling", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-8943724:r:Regulation of PTEN gene transcription", "R-MMU-1632852:r:Macroautophagy", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-166208:r:mTORC1-mediated signalling", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-HSA-166208:r:mTORC1-mediated signalling", "R-RNO-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-DRE-166208:r:mTORC1-mediated signalling", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-166208:r:mTORC1-mediated signalling", "R-XTR-166208:r:mTORC1-mediated signalling", "R-XTR-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-1632852:r:Macroautophagy", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-165159:r:MTOR signalling", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5674135:r:MAP2K and MAPK activation", "R-DDI-1632852:r:Macroautophagy", "R-BTA-166208:r:mTORC1-mediated signalling", "R-MMU-165159:r:MTOR signalling", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-166208:r:mTORC1-mediated signalling", "R-BTA-165159:r:MTOR signalling", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-XTR-6798695:r:Neutrophil degranulation", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-BTA-1632852:r:Macroautophagy", "R-XTR-165159:r:MTOR signalling", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-DRE-165159:r:MTOR signalling", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-166208:r:mTORC1-mediated signalling", "R-HSA-1632852:r:Macroautophagy", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-165159:r:MTOR signalling", "R-DME-1632852:r:Macroautophagy", "R-DME-165159:r:MTOR signalling", "R-XTR-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DRE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR015020": {"description": "Rv2525c-like, glycoside hydrolase-like domain", "go_ids": [], "go_terms": [], "name": "Rv2525c-like_Glyco_Hydro-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015021": {"description": "Ester hydrolase C11orf54, Domain of unknown function DUF1907", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "C11orf54_DUF1907", "pathway_ids": ["PWY-5525"], "pathways": ["PWY-5525:t:D-glucuronate degradation I"], "type": "Domain"}, "IPR015022": {"description": "Microtubule-associated serine/threonine-protein kinase, pre-PK domain", "go_ids": ["GO:0000287", "GO:0004674", "GO:0005524", "GO:0006468"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P"], "name": "MAST_pre-PK_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015024": {"description": "PoNi, N-terminal", "go_ids": [], "go_terms": [], "name": "PoNi_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015025": {"description": "PoNi, C-terminal", "go_ids": [], "go_terms": [], "name": "PoNi_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015026": {"description": "Protein of unknown function DUF1912", "go_ids": [], "go_terms": [], "name": "DUF1912", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015027": {"description": "Receptor-binding protein of phage tail base-plate Siphoviridae, head", "go_ids": [], "go_terms": [], "name": "Caudo_bapla_RBP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015029": {"description": "Monodechloroaminopyrrolnitrin synthase PrnB", "go_ids": [], "go_terms": [], "name": "PrnB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015030": {"description": "Retinoblastoma-associated protein, C-terminal", "go_ids": [], "go_terms": [], "name": "RB_C", "pathway_ids": ["R-HSA-174178", "R-HSA-69205", "R-HSA-2559585", "R-RNO-2173796", "R-RNO-174178", "R-HSA-9682706", "R-RNO-2559584", "R-HSA-69231", "R-MMU-2559584", "R-HSA-9764790", "R-MMU-174178", "R-HSA-9661070", "R-HSA-9841922", "R-MMU-69200", "R-HSA-9617828", "R-MMU-69202", "R-MMU-1538133", "R-HSA-69200", "R-HSA-69656", "R-HSA-1538133", "R-HSA-2559584", "R-RNO-69656", "R-HSA-2299718", "R-RNO-69200", "R-HSA-2173796", "R-RNO-1538133", "R-HSA-9661069", "R-HSA-113501", "R-RNO-69202", "R-RNO-2299718", "R-HSA-9694686", "R-HSA-9687136", "R-HSA-1362300", "R-MMU-2173796", "R-MMU-113501", "R-RNO-69231", "R-MMU-69656", "R-HSA-9725371", "R-RNO-113501", "R-HSA-1362277", "R-MMU-2299718", "R-HSA-6804114", "R-RNO-9841922", "R-HSA-69202", "R-HSA-8940973", "R-MMU-69231"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9661070:r:Defective translocation of RB1 mutants to the nucleus", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1538133:r:G0 and Early G1", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-1538133:r:G0 and Early G1", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Domain"}, "IPR015031": {"description": "Capsid protein VP4, Picornavirus", "go_ids": ["GO:0019030"], "go_terms": ["GO:0019030:icosahedral viral capsid:C"], "name": "Capsid_VP4_Picornavir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015032": {"description": "Thoeris protein ThsB, TIR-like domain", "go_ids": [], "go_terms": [], "name": "ThsB__TIR-like_domain", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Domain"}, "IPR015033": {"description": "HBS1-like protein, N-terminal", "go_ids": [], "go_terms": [], "name": "HBS1-like_N", "pathway_ids": ["R-SCE-429958", "R-RNO-429958", "R-MMU-9954714", "R-DME-429958", "R-DME-9954714", "R-SPO-9954714", "R-MMU-429958", "R-HSA-429958", "R-SPO-429958", "R-SCE-9954714", "R-RNO-9954714", "R-HSA-9954714"], "pathways": ["R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "type": "Domain"}, "IPR015034": {"description": "Basophilic leukemia-expressed protein Bles03-like", "go_ids": [], "go_terms": [], "name": "Bles03", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015035": {"description": "Domain of unknown function DUF1918", "go_ids": [], "go_terms": [], "name": "DUF1918", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015036": {"description": "E3 ubiquitin-protein ligase NRDP1", "go_ids": ["GO:0016567", "GO:0061630"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0061630:ubiquitin protein ligase activity:F"], "name": "NRDP1", "pathway_ids": ["PWY-7511", "R-HSA-983168", "R-HSA-1358803", "R-DRE-1358803", "R-MMU-983168", "R-MMU-1358803", "R-DRE-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DRE-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR015037": {"description": "Protein of unknown function DUF1919", "go_ids": [], "go_terms": [], "name": "DUF1919", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015038": {"description": "Glutarate 2-hydroxylase GlaH", "go_ids": ["GO:0050498", "GO:0005506"], "go_terms": ["GO:0050498:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated:F", "GO:0005506:iron ion binding:F"], "name": "GlaH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015039": {"description": "Neutrophil cytosol factor 1, C-terminal", "go_ids": [], "go_terms": [], "name": "NCF1_C", "pathway_ids": ["R-RNO-1236973", "R-MMU-1222556", "R-HSA-3299685", "R-RNO-9013149", "R-HSA-1236973", "R-MMU-4420097", "R-RNO-1222556", "R-MMU-9013404", "R-MMU-3299685", "R-MMU-1236973", "R-RNO-3299685", "R-RNO-5668599", "R-HSA-9013423", "R-HSA-4420097", "R-HSA-9013149", "R-HSA-9013404", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-1222556", "R-MMU-5668599", "R-RNO-9013404", "R-MMU-9013149", "R-HSA-5668599", "R-RNO-4420097"], "pathways": ["R-RNO-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR015040": {"description": "Bcl-x interacting, BH3 domain", "go_ids": [], "go_terms": [], "name": "Bcl-x_interacting_BH3_dom", "pathway_ids": ["R-MMU-111453", "R-HSA-193648", "R-HSA-9607240", "R-RNO-111453", "R-HSA-111453", "R-HSA-6802952", "R-MMU-193648", "R-HSA-111446", "R-HSA-9614657", "R-MMU-111446", "R-HSA-8862803", "R-RNO-111446", "R-HSA-8952158", "R-RNO-193648"], "pathways": ["R-MMU-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-MMU-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-RNO-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-RNO-193648:r:NRAGE signals death through JNK"], "type": "Domain"}, "IPR015041": {"description": "Osmosensory transporter coiled coil", "go_ids": [], "go_terms": [], "name": "Osmo_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015042": {"description": "BPS (Between PH and SH2) domain", "go_ids": [], "go_terms": [], "name": "BPS-dom", "pathway_ids": ["R-RNO-1306955", "R-HSA-9607240", "R-MMU-9607240", "R-BTA-9696273", "R-SSC-9607240", "R-MMU-1306955", "R-HSA-74751", "R-RNO-9607240", "R-RNO-74749", "R-MMU-210993", "R-HSA-1306955", "R-BTA-186763", "R-HSA-8853659", "R-BTA-8853659", "R-MMU-74751", "R-SSC-8853659", "R-MMU-186763", "R-BTA-1433557", "R-BTA-1306955", "R-MMU-74713", "R-SSC-74749", "R-MMU-1433557", "R-RNO-210993", "R-HSA-74713", "R-HSA-210993", "R-RNO-8853659", "R-MMU-8853659", "R-RNO-9696273", "R-HSA-1433557", "R-HSA-74749", "R-RNO-74713", "R-HSA-186763", "R-RNO-1433557", "R-HSA-9648895", "R-RNO-74751", "R-SSC-74713", "R-BTA-210993", "R-SSC-74751", "R-MMU-9696273", "R-MMU-74749", "R-SSC-1433557", "R-RNO-186763", "R-HSA-9696273"], "pathways": ["R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-MMU-9607240:r:FLT3 Signaling", "R-BTA-9696273:r:RND1 GTPase cycle", "R-SSC-9607240:r:FLT3 Signaling", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-RNO-9607240:r:FLT3 Signaling", "R-RNO-74749:r:Signal attenuation", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-BTA-186763:r:Downstream signal transduction", "R-HSA-8853659:r:RET signaling", "R-BTA-8853659:r:RET signaling", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-SSC-8853659:r:RET signaling", "R-MMU-186763:r:Downstream signal transduction", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-74713:r:IRS activation", "R-SSC-74749:r:Signal attenuation", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-74713:r:IRS activation", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-74749:r:Signal attenuation", "R-RNO-74713:r:IRS activation", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-SSC-74713:r:IRS activation", "R-BTA-210993:r:Tie2 Signaling", "R-SSC-74751:r:Insulin receptor signalling cascade", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-74749:r:Signal attenuation", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR015043": {"description": "Bacteriophage PRD1, P5, spike N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_PRD1_P5_spike_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015044": {"description": "Bacteriophage PRD1, spike protein P5, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_PRD1_P5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015045": {"description": "Mannosyltransferase/phosphorylase 1-like, Leishmania", "go_ids": [], "go_terms": [], "name": "MPT-1-like_LmxM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015046": {"description": "Lactococcin-A immunity protein-like", "go_ids": ["GO:0030153"], "go_terms": ["GO:0030153:bacteriocin immunity:P"], "name": "LciA_Immunity-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015047": {"description": "Synaptojanin-1/2, RNA recognition motif", "go_ids": [], "go_terms": [], "name": "SYNJ1/2_RRM", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-6367", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664", "R-CEL-8856828", "R-CEL-1855204", "R-MMU-8856828", "R-RNO-1660499", "R-HSA-8856828", "R-HSA-1855204", "R-CEL-1660499", "R-HSA-1855183", "R-RNO-1855204", "R-RNO-8856828", "R-CEL-1855183", "R-MMU-1855183", "R-MMU-1855204", "R-HSA-1660499", "R-MMU-1660499", "R-RNO-1855183"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol"], "type": "Domain"}, "IPR015048": {"description": "Domain of unknown function DUF1899", "go_ids": [], "go_terms": [], "name": "DUF1899", "pathway_ids": ["R-DDI-6798695", "R-HSA-9636383"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion"], "type": "Domain"}, "IPR015049": {"description": "Trimerisation motif", "go_ids": [], "go_terms": [], "name": "Trimer_CC", "pathway_ids": ["R-HSA-9636383"], "pathways": ["R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion"], "type": "Domain"}, "IPR015050": {"description": "Bypass of forespore C, C-terminal", "go_ids": [], "go_terms": [], "name": "BofC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015051": {"description": "Protein YoaG", "go_ids": [], "go_terms": [], "name": "YoaG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015053": {"description": "Protein of unknown function DUF1871", "go_ids": [], "go_terms": [], "name": "DUF1871", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015055": {"description": "STIV B116-like", "go_ids": [], "go_terms": [], "name": "STIV_B116-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015056": {"description": "Nuclear receptor-binding factor 2, C-terminal", "go_ids": ["GO:0006914"], "go_terms": ["GO:0006914:autophagy:P"], "name": "NRBF2_C", "pathway_ids": ["R-RNO-383280", "R-MMU-383280", "R-HSA-383280"], "pathways": ["R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-HSA-383280:r:Nuclear Receptor transcription pathway"], "type": "Domain"}, "IPR015057": {"description": "Rv2632c-like", "go_ids": [], "go_terms": [], "name": "Rv2632c-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015058": {"description": "Protein of unknown function DUF1878", "go_ids": [], "go_terms": [], "name": "DUF1878", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015059": {"description": "Calcium-dependent cell adhesion molecule, N-terminal", "go_ids": ["GO:0016020", "GO:0098609"], "go_terms": ["GO:0016020:membrane:C", "GO:0098609:cell-cell adhesion:P"], "name": "Ca_cell_adhesion_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015060": {"description": "Aca2/YdiL-like", "go_ids": [], "go_terms": [], "name": "Aca2_YdiL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015061": {"description": "Domain of unknown function DUF1882", "go_ids": [], "go_terms": [], "name": "DUF1882", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015062": {"description": "Protein of unknown function DUF1885", "go_ids": [], "go_terms": [], "name": "DUF1885", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015063": {"description": "USP8 dimerisation domain", "go_ids": [], "go_terms": [], "name": "USP8_dimer", "pathway_ids": ["R-HSA-5689901", "R-MMU-5689880", "R-SPO-5689901", "R-MMU-4641263", "R-DDI-5689901", "R-HSA-5689880", "R-HSA-4641263", "R-MMU-5689901", "R-MMU-6807004", "R-HSA-6807004", "R-RNO-5689901", "R-HSA-1358803", "R-MMU-1358803"], "pathways": ["R-HSA-5689901:r:Metalloprotease DUBs", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SPO-5689901:r:Metalloprotease DUBs", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-DDI-5689901:r:Metalloprotease DUBs", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-RNO-5689901:r:Metalloprotease DUBs", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling"], "type": "Domain"}, "IPR015064": {"description": "Sporulation inhibitor A", "go_ids": [], "go_terms": [], "name": "Sda", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015065": {"description": "Surface composition regulator", "go_ids": [], "go_terms": [], "name": "GlgS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015066": {"description": "Domain of unknown function DUF1902", "go_ids": [], "go_terms": [], "name": "DUF1902", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015067": {"description": "Protein of unknown function DUF1893, TM1506-like", "go_ids": [], "go_terms": [], "name": "DUF1893_TM1506-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015068": {"description": "Protein of unknown function DUF1877", "go_ids": [], "go_terms": [], "name": "DUF1877", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015069": {"description": "2H-phosphodiesterase-like, Domain of unknown function DUF1868", "go_ids": [], "go_terms": [], "name": "2H-PEstase_DUF1868", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015070": {"description": "DJBP, EF-hand domain", "go_ids": [], "go_terms": [], "name": "EF_hand_DJBP", "pathway_ids": ["R-BTA-445355", "R-HSA-3928663", "R-HSA-5625900", "R-HSA-5627123", "R-HSA-416572", "R-HSA-445355", "R-HSA-3928664", "R-RNO-445355", "R-BTA-3928664", "R-MMU-5627123", "R-HSA-5625740", "R-MMU-445355", "R-BTA-5627123", "R-HSA-5627117"], "pathways": ["R-BTA-445355:r:Smooth Muscle Contraction", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-445355:r:Smooth Muscle Contraction", "R-BTA-3928664:r:Ephrin signaling", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-MMU-445355:r:Smooth Muscle Contraction", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Domain"}, "IPR015071": {"description": "Bypass-of-forespore C, N-terminal", "go_ids": [], "go_terms": [], "name": "BOFC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015072": {"description": "Outer capsid protein VP9/VP10/VP11", "go_ids": [], "go_terms": [], "name": "VP9/VP10/VP11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015073": {"description": "Domain of unknown function DUF1883", "go_ids": [], "go_terms": [], "name": "DUF1883", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015074": {"description": "Protein of unknown function DUF1867", "go_ids": [], "go_terms": [], "name": "DUF1867", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015075": {"description": "Acetylaranotin biosynthesis cluster protein L", "go_ids": [], "go_terms": [], "name": "AtaL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015076": {"description": "Vasopressin V1 receptor, C-terminal", "go_ids": [], "go_terms": [], "name": "V1R_C", "pathway_ids": ["R-MMU-416476", "R-MMU-388479", "R-RNO-388479", "R-HSA-416476", "R-RNO-416476", "R-HSA-388479", "R-HSA-5619099"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-388479:r:Vasopressin-like receptors", "R-RNO-388479:r:Vasopressin-like receptors", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-388479:r:Vasopressin-like receptors", "R-HSA-5619099:r:Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)"], "type": "Domain"}, "IPR015077": {"description": "Domain of unknown function DUF1858", "go_ids": [], "go_terms": [], "name": "DUF1858", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015078": {"description": "DP-EP family", "go_ids": [], "go_terms": [], "name": "DP-EP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015079": {"description": "Protein of unknown function DUF1889", "go_ids": [], "go_terms": [], "name": "DUF1889", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015080": {"description": "Protein of unknown function DUF1892", "go_ids": [], "go_terms": [], "name": "DUF1892", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015082": {"description": "Protein of unknown function DUF1896", "go_ids": [], "go_terms": [], "name": "DUF1896", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015083": {"description": "Polyketide synthase NorB/C/GfsB-E-like, docking domain", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "NorB/c/GfsB-D-like_docking", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015084": {"description": "Quinohemoprotein amine dehydrogenase, gamma subunit, structural domain", "go_ids": ["GO:0016638"], "go_terms": ["GO:0016638:oxidoreductase activity, acting on the CH-NH2 group of donors:F"], "name": "QH-AmDH_gsu_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015085": {"description": "Bacteriophage T4, Gp59, helicase assembly protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp59_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015086": {"description": "Bacteriophage T4, Gp59, helicase assembly protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp59_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015087": {"description": "Necrosis inducing protein-1", "go_ids": [], "go_terms": [], "name": "NIP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015088": {"description": "Zinc finger, DNA-directed DNA polymerase, family B, alpha", "go_ids": ["GO:0003887", "GO:0006260"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P"], "name": "Znf_DNA-dir_DNA_pol_B_alpha", "pathway_ids": ["R-MMU-174430", "R-RNO-68962", "R-HSA-69205", "R-SCE-69091", "R-DME-113501", "R-RNO-69183", "R-DME-68962", "R-RNO-69166", "R-DDI-68952", "R-DDI-68962", "R-SPO-69091", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-RNO-68952", "R-RNO-174411", "R-SCE-68952", "R-SPO-69166", "R-HSA-113501", "R-HSA-68952", "R-SCE-69183", "R-DDI-113501", "R-DDI-69091", "R-MMU-68962", "R-DDI-69183", "R-RNO-174430", "R-HSA-174430", "R-SPO-69183", "R-MMU-113501", "R-DME-69091", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-SCE-113501", "R-SCE-68962", "R-DDI-69166", "R-RNO-69091", "R-HSA-9710421", "R-MMU-68952", "R-RNO-113501", "R-SPO-113501", "R-SPO-68952", "R-HSA-69183", "R-SCE-69166", "R-MMU-69166", "R-SPO-68962", "R-HSA-69091", "R-MMU-174411", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-SCE-69091:r:Polymerase switching", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-DME-68962:r:Activation of the pre-replicative complex", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-DDI-68952:r:DNA replication initiation", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-69091:r:Polymerase switching", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-RNO-68952:r:DNA replication initiation", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-SCE-68952:r:DNA replication initiation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-68952:r:DNA replication initiation", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DDI-69091:r:Polymerase switching", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-69091:r:Polymerase switching", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DDI-69166:r:Removal of the Flap Intermediate", "R-RNO-69091:r:Polymerase switching", "R-HSA-9710421:r:Defective pyroptosis", "R-MMU-68952:r:DNA replication initiation", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-68952:r:DNA replication initiation", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-69091:r:Polymerase switching", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Domain"}, "IPR015089": {"description": "Cytochrome b-c1 complex subunit 10", "go_ids": ["GO:0006122"], "go_terms": ["GO:0006122:mitochondrial electron transport, ubiquinol to cytochrome c:P"], "name": "UQCR", "pathway_ids": ["R-BTA-9865881", "R-HSA-9865881", "R-HSA-611105", "R-MMU-611105", "R-BTA-611105", "R-MMU-9865881"], "pathways": ["R-BTA-9865881:r:Complex III assembly", "R-HSA-9865881:r:Complex III assembly", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly"], "type": "Family"}, "IPR015090": {"description": "Antitoxin epsilon/PezA domain", "go_ids": ["GO:0009636", "GO:0015643", "GO:0031342"], "go_terms": ["GO:0009636:response to toxic substance:P", "GO:0015643:toxic substance binding:F", "GO:0031342:negative regulation of cell killing:P"], "name": "Epsilon_PezA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015091": {"description": "Surfactant protein C, N-terminal propeptide", "go_ids": [], "go_terms": [], "name": "Surfactant_protein_propep", "pathway_ids": ["R-HSA-5683826", "R-HSA-5688890", "R-RNO-5683826", "R-HSA-5688354", "R-MMU-5683826", "R-HSA-5688849"], "pathways": ["R-HSA-5683826:r:Surfactant metabolism", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-RNO-5683826:r:Surfactant metabolism", "R-HSA-5688354:r:Defective pro-SFTPC causes SMDP2 and RDS", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5"], "type": "Domain"}, "IPR015093": {"description": "Card1, endonuclease domain", "go_ids": [], "go_terms": [], "name": "Card1_endonucl_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015094": {"description": "Integrase, lambda-type, N-terminal DNA-binding", "go_ids": ["GO:0003677", "GO:0008907", "GO:0015074"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008907:integrase activity:F", "GO:0015074:DNA integration:P"], "name": "Integrase_lambda-typ_DNA-bd_N", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR015095": {"description": "Alkylated DNA repair protein AlkB, homologue 8, N-terminal", "go_ids": ["GO:0016706", "GO:0008168"], "go_terms": ["GO:0016706:2-oxoglutarate-dependent dioxygenase activity:F", "GO:0008168:methyltransferase activity:F"], "name": "AlkB_hom8_N", "pathway_ids": ["PWY-6829", "PWY-7888", "R-HSA-6782315"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR015096": {"description": "Far upstream element-binding protein, C-terminal", "go_ids": ["GO:0006355", "GO:0003676"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003676:nucleic acid binding:F"], "name": "FUBP_C", "pathway_ids": ["R-RNO-450604", "R-MMU-450604", "R-HSA-380994", "R-HSA-450604"], "pathways": ["R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA"], "type": "Domain"}, "IPR015097": {"description": "Lung surfactant protein D coiled-coil trimerisation", "go_ids": [], "go_terms": [], "name": "Surfac_D-trimer", "pathway_ids": ["R-RNO-5686938", "R-HSA-9705671", "R-MMU-391160", "R-MMU-166016", "R-HSA-166016", "R-SSC-166016", "R-RNO-391160", "R-HSA-168179", "R-RNO-5683826", "R-MMU-5686938", "R-HSA-391160", "R-BTA-5686938", "R-SSC-5686938", "R-BTA-166016", "R-HSA-5688890", "R-HSA-5683826", "R-SSC-391160", "R-HSA-9692916", "R-BTA-391160", "R-HSA-198933", "R-BTA-5683826", "R-HSA-5686938", "R-RNO-166016", "R-SSC-5683826", "R-MMU-5683826", "R-HSA-5688849"], "pathways": ["R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-SSC-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-SSC-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-BTA-5683826:r:Surfactant metabolism", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5"], "type": "Domain"}, "IPR015098": {"description": "EBP50, C-terminal", "go_ids": [], "go_terms": [], "name": "EBP50_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015099": {"description": "Exotoxin A catalytic domain", "go_ids": ["GO:0047286"], "go_terms": ["GO:0047286:NAD+-diphthamide ADP-ribosyltransferase activity:F"], "name": "Exotox-A_cataly_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015100": {"description": "Anti-Sigma Factor A", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "AsiA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015102": {"description": "Transcriptional regulator HTH-type, FeoC", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_HTH_FeoC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015103": {"description": "Protein-tyrosine phosphatase, YopH, N-terminal", "go_ids": ["GO:0004725", "GO:0006470"], "go_terms": ["GO:0004725:protein tyrosine phosphatase activity:F", "GO:0006470:protein dephosphorylation:P"], "name": "ProtTyrPase_YopH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015104": {"description": "Beta-2-glycoprotein-1 fifth domain", "go_ids": [], "go_terms": [], "name": "Sushi_2", "pathway_ids": ["R-HSA-114608", "R-CFA-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-CFA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR015105": {"description": "Type-2 restriction enzyme NgoMIV", "go_ids": ["GO:0009036", "GO:0009307"], "go_terms": ["GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "NgoMIV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015106": {"description": "Pas factor saposin domain", "go_ids": [], "go_terms": [], "name": "Pas_Saposin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015107": {"description": "Protein-glutamine gamma-glutamyltransferase", "go_ids": ["GO:0003810"], "go_terms": ["GO:0003810:protein-glutamine gamma-glutamyltransferase activity:F"], "name": "Transglut_prok", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015108": {"description": "P3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "P3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015109": {"description": "Restriction endonuclease, type II, EcoRII, C-terminal", "go_ids": ["GO:0003677", "GO:0009036", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_II_EcoRII_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015110": {"description": "YopE, N-terminal domain", "go_ids": ["GO:0050765"], "go_terms": ["GO:0050765:negative regulation of phagocytosis:P"], "name": "YopE_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015111": {"description": "Hut operon regulatory protein HutP", "go_ids": [], "go_terms": [], "name": "Regulatory_HutP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015112": {"description": "Staphostatin A", "go_ids": [], "go_terms": [], "name": "Staphostatin_A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015113": {"description": "Staphostatin B", "go_ids": [], "go_terms": [], "name": "Staphostatin_B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015115": {"description": "Centromere protein CENP-B, C-terminal domain", "go_ids": ["GO:0000775", "GO:0003677", "GO:0003682"], "go_terms": ["GO:0000775:chromosome, centromeric region:C", "GO:0003677:DNA binding:F", "GO:0003682:chromatin binding:F"], "name": "CenpB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015116": {"description": "Cdc42 binding domain-like", "go_ids": [], "go_terms": [], "name": "Cdc42-bd-like", "pathway_ids": ["R-RNO-9842663", "R-HSA-9842663", "R-MMU-9842663"], "pathways": ["R-RNO-9842663:r:Signaling by LTK", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-9842663:r:Signaling by LTK"], "type": "Domain"}, "IPR015117": {"description": "Ig protease IdeS", "go_ids": ["GO:0008233"], "go_terms": ["GO:0008233:peptidase activity:F"], "name": "IdeS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015118": {"description": "5-aminolevulinate synthase presequence", "go_ids": ["GO:0003870", "GO:0005759", "GO:0006778", "GO:0030170"], "go_terms": ["GO:0003870:5-aminolevulinate synthase activity:F", "GO:0005759:mitochondrial matrix:C", "GO:0006778:porphyrin-containing compound metabolic process:P", "GO:0030170:pyridoxal phosphate binding:F"], "name": "5aminolev_synth_preseq", "pathway_ids": ["PWY-5189", "PWY-7536", "R-HSA-1989781", "R-RNO-189451", "R-MMU-9837999", "R-HSA-2151201", "R-DRE-189451", "R-MMU-189451", "R-GGA-421984", "R-HSA-9837999", "R-RNO-9837999", "R-BTA-189451", "R-HSA-189451"], "pathways": ["PWY-5189:t:tetrapyrrole biosynthesis II (from glycine)", "PWY-7536:t:2-amino-3-hydroxycyclopent-2-enone biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-189451:r:Heme biosynthesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DRE-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-GGA-421984:r:Heme synthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Domain"}, "IPR015120": {"description": "Siah interacting protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Siah-Interact_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015121": {"description": "DNA fragmentation factor 45kDa, middle domain", "go_ids": [], "go_terms": [], "name": "DNA_fragmentation_mid_dom", "pathway_ids": ["R-HSA-140342", "R-MMU-140342"], "pathways": ["R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-140342:r:Apoptosis induced DNA fragmentation"], "type": "Domain"}, "IPR015122": {"description": "Excisionase from transposon Tn916", "go_ids": [], "go_terms": [], "name": "Tn916-Xis", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015123": {"description": "Bcr-Abl oncoprotein oligomerisation", "go_ids": ["GO:0004674", "GO:0005096", "GO:0006468", "GO:0007165"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005096:GTPase activator activity:F", "GO:0006468:protein phosphorylation:P", "GO:0007165:signal transduction:P"], "name": "Bcr-Abl_oncoprot_oligo", "pathway_ids": ["R-RNO-9013026", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-9013149", "R-RNO-9013148", "R-HSA-9013106", "R-MMU-9013148", "R-MMU-9013404", "R-RNO-9013423", "R-HSA-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-MMU-9013423", "R-HSA-8980692", "R-MMU-9013026", "R-HSA-9013148", "R-HSA-9013026", "R-RNO-9013404", "R-RNO-9013106", "R-MMU-9013149", "R-HSA-5655302", "R-HSA-1839117"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR015124": {"description": "Trehalose 2-sulfotransferase", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "Stf0", "pathway_ids": ["PWY-7746"], "pathways": ["PWY-7746:t:mycobacterial sulfolipid biosynthesis"], "type": "Family"}, "IPR015125": {"description": "Tumour suppressor p53-binding protein-1, Tudor domain", "go_ids": [], "go_terms": [], "name": "53-BP1_Tudor", "pathway_ids": ["R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-69473", "R-MMU-3232118", "R-HSA-3232118", "R-HSA-5693565", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR015126": {"description": "Mu DNA binding, I gamma subdomain", "go_ids": [], "go_terms": [], "name": "Mu_I-gamma", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015127": {"description": "Gastric H+/K+-transporter P-type ATPase, N-terminal", "go_ids": ["GO:0000287", "GO:0005524", "GO:0008900", "GO:1902600", "GO:0016020"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0005524:ATP binding:F", "GO:0008900:P-type potassium:proton transporter activity:F", "GO:1902600:proton transmembrane transport:P", "GO:0016020:membrane:C"], "name": "ATPase_P-typ_H/K-transp_N", "pathway_ids": ["R-HSA-936837", "R-RNO-936837", "R-MMU-936837"], "pathways": ["R-HSA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-MMU-936837:r:Ion transport by P-type ATPases"], "type": "Domain"}, "IPR015128": {"description": "Aurora-A binding", "go_ids": [], "go_terms": [], "name": "Aurora-A-bd", "pathway_ids": ["R-MMU-8854518", "R-MMU-6804756", "R-HSA-6804756", "R-XTR-6804756", "R-HSA-8854518", "R-XTR-8854518"], "pathways": ["R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-XTR-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-XTR-8854518:r:AURKA Activation by TPX2"], "type": "Domain"}, "IPR015129": {"description": "Titin, Z repeat", "go_ids": [], "go_terms": [], "name": "Titin_Z_rpt", "pathway_ids": ["R-HSA-114608", "R-HSA-390522"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-HSA-390522:r:Striated Muscle Contraction"], "type": "Repeat"}, "IPR015130": {"description": "D-Lysine 5,6-aminomutase alpha subunit", "go_ids": [], "go_terms": [], "name": "Lys-AminoMut_A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015131": {"description": "Killer toxin, Kp4", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Killer_tox_Kp4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015132": {"description": "L27-2", "go_ids": [], "go_terms": [], "name": "L27_2", "pathway_ids": ["R-HSA-420029", "R-HSA-9705677"], "pathways": ["R-HSA-420029:r:Tight junction interactions", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction"], "type": "Domain"}, "IPR015133": {"description": "Effector protein HopAB, E3 ubiquitin ligase domain", "go_ids": [], "go_terms": [], "name": "E3_ubiquit_lig_AvrPtoB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015134": {"description": "Calcineurin-binding protein cabin-1, MEF2-binding domain", "go_ids": [], "go_terms": [], "name": "MEF2-bd", "pathway_ids": ["R-HSA-2559584", "R-RNO-2559584"], "pathways": ["R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Domain"}, "IPR015135": {"description": "Stannin transmembrane", "go_ids": [], "go_terms": [], "name": "SNN_transmemb", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015136": {"description": "Stannin unstructured linker", "go_ids": [], "go_terms": [], "name": "SNN_linker", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015137": {"description": "Stannin cytoplasmic", "go_ids": [], "go_terms": [], "name": "SNN_cytoplasm", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015138": {"description": "Salmonella invasion protein A, N-terminal", "go_ids": [], "go_terms": [], "name": "SipA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015139": {"description": "Cag pathogenicity island protein, CagZ", "go_ids": [], "go_terms": [], "name": "CagPAI_CagZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015141": {"description": "Phospholipase A2, prokaryotic/fungal", "go_ids": [], "go_terms": [], "name": "PLipase_A2_prok/fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015142": {"description": "Smac/DIABLO protein", "go_ids": ["GO:0006915", "GO:0005739"], "go_terms": ["GO:0006915:apoptotic process:P", "GO:0005739:mitochondrion:C"], "name": "Smac_DIABLO", "pathway_ids": ["R-HSA-111469", "R-HSA-111457", "R-MMU-9627069", "R-MMU-111463", "R-MMU-111457", "R-MMU-111464", "R-HSA-111464", "R-HSA-9627069", "R-XTR-111457", "R-HSA-111463", "R-MMU-111469"], "pathways": ["R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-MMU-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-XTR-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response"], "type": "Family"}, "IPR015143": {"description": "L27-1", "go_ids": [], "go_terms": [], "name": "L27_1", "pathway_ids": ["R-MMU-451308", "R-DRE-438066", "R-CEL-438066", "R-HSA-8849932", "R-HSA-442982", "R-CEL-5625900", "R-CFA-451308", "R-CFA-8849932", "R-CEL-451308", "R-CFA-5673001", "R-RNO-451308", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-447038", "R-HSA-9617324", "R-DME-438066", "R-HSA-399719", "R-HSA-451308", "R-XTR-8849932", "R-CEL-6794361", "R-MMU-8849932", "R-MMU-438066", "R-RNO-399719", "R-RNO-438066", "R-DME-451308", "R-HSA-5673001", "R-DRE-8849932", "R-DME-8849932", "R-HSA-438066", "R-HSA-9620244", "R-CFA-399719", "R-XTR-438066", "R-DME-6794361", "R-CFA-438066", "R-RNO-8849932", "R-HSA-9609736", "R-MMU-399719", "R-DME-5625900", "R-CEL-8849932"], "pathways": ["R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-447038:r:NrCAM interactions", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-CEL-6794361:r:Neurexins and neuroligins", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9620244:r:Long-term potentiation", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-6794361:r:Neurexins and neuroligins", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-DME-5625900:r:RHO GTPases activate CIT", "R-CEL-8849932:r:Synaptic adhesion-like molecules"], "type": "Domain"}, "IPR015144": {"description": "Type III secretion system effector delivery regulator TyeA", "go_ids": [], "go_terms": [], "name": "T3SS_TyeA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015145": {"description": "L27-N", "go_ids": [], "go_terms": [], "name": "L27_N", "pathway_ids": ["R-HSA-9692912", "R-HSA-420029", "R-HSA-9705677"], "pathways": ["R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-HSA-420029:r:Tight junction interactions", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction"], "type": "Domain"}, "IPR015146": {"description": "Ribonucleotide reductase, stirrup", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "RNR_stirrup", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015147": {"description": "PI-PfuI intein endonuclease, subdomain", "go_ids": [], "go_terms": [], "name": "PI-PfuI_intein_endonucl_subdom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015148": {"description": "Bacteriophage PP7 capsid", "go_ids": [], "go_terms": [], "name": "Phage_PP7_CP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015149": {"description": "Thrombomodulin-like, EGF-like", "go_ids": ["GO:0016020", "GO:0004888"], "go_terms": ["GO:0016020:membrane:C", "GO:0004888:transmembrane signaling receptor activity:F"], "name": "Tme5_EGF-like", "pathway_ids": ["R-HSA-140875", "R-HSA-202733", "R-MMU-202733", "R-MMU-140875"], "pathways": ["R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation"], "type": "Domain"}, "IPR015150": {"description": "Haemadin", "go_ids": [], "go_terms": [], "name": "Haemadin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015151": {"description": "Beta-adaptin appendage, C-terminal subdomain", "go_ids": ["GO:0006886", "GO:0016192", "GO:0030131"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P", "GO:0030131:clathrin adaptor complex:C"], "name": "B-adaptin_app_sub_C", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-HSA-2132295", "R-HSA-6802952", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-432722", "R-HSA-9918485", "R-BTA-416993", "R-DDI-437239", "R-MMU-5099900", "R-RNO-8964038", "R-DDI-8856825", "R-DDI-8866427", "R-MMU-2132295", "R-RNO-177504", "R-MMU-8964038", "R-DDI-8856828", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-MMU-432720", "R-HSA-5140745", "R-RNO-5099900", "R-HSA-432722", "R-DDI-8964038", "R-RNO-8866427", "R-BTA-2132295", "R-RNO-432722", "R-MMU-416993", "R-BTA-8856828", "R-RNO-2132295", "R-HSA-416993", "R-MMU-437239", "R-RNO-8856825", "R-RNO-437239", "R-RNO-432720", "R-BTA-5099900", "R-HSA-432720", "R-DDI-432720", "R-HSA-167590", "R-HSA-437239", "R-HSA-5099900", "R-HSA-9679191", "R-MMU-5140745", "R-BTA-177504", "R-HSA-164940", "R-HSA-177504", "R-HSA-8866427", "R-BTA-8856825", "R-BTA-8964038", "R-HSA-8856825", "R-HSA-3928665", "R-MMU-8866427", "R-MMU-177504", "R-BTA-432722", "R-BTA-5140745", "R-HSA-8964038", "R-RNO-416993", "R-HSA-182218"], "pathways": ["R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DDI-437239:r:Recycling pathway of L1", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-8964038:r:LDL clearance", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-MMU-8964038:r:LDL clearance", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-BTA-2132295:r:MHC class II antigen presentation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-437239:r:Recycling pathway of L1", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-8964038:r:LDL clearance", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Domain"}, "IPR015152": {"description": "Growth hormone/erythropoietin receptor, ligand binding", "go_ids": [], "go_terms": [], "name": "Growth/epo_recpt_lig-bind", "pathway_ids": ["R-RNO-1170546", "R-MMU-1170546", "R-HSA-1170546", "R-SSC-9027276", "R-HSA-9006335", "R-MMU-982772", "R-SSC-9006335", "R-RNO-982772", "R-HSA-9027283", "R-HSA-6788467", "R-MMU-9006335", "R-HSA-9027284", "R-RNO-9027276", "R-MMU-9020956", "R-SSC-9027284", "R-RNO-9027284", "R-HSA-9027276", "R-HSA-982772", "R-MMU-912526", "R-HSA-76009", "R-RNO-9006335", "R-MMU-512988", "R-SSC-982772", "R-MMU-9027276", "R-HSA-9027277", "R-MMU-6788467", "R-SSC-1170546", "R-MMU-5673001", "R-HSA-9020956", "R-MMU-9027284"], "pathways": ["R-RNO-1170546:r:Prolactin receptor signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-MMU-982772:r:Growth hormone receptor signaling", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-9020956:r:Interleukin-27 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-982772:r:Growth hormone receptor signaling", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-1170546:r:Prolactin receptor signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-9027284:r:Erythropoietin activates RAS"], "type": "Domain"}, "IPR015153": {"description": "EF-hand domain, type 1", "go_ids": [], "go_terms": [], "name": "EF-hand_dom_typ1", "pathway_ids": ["R-DME-9035034", "R-CEL-9913351", "R-RNO-390522", "R-MMU-9913351", "R-DME-446388", "R-HSA-390522", "R-DME-114608", "R-MMU-390522", "R-HSA-9913351", "R-HSA-3000171", "R-HSA-9619665", "R-DME-9013418", "R-RNO-9913351"], "pathways": ["R-DME-9035034:r:RHOF GTPase cycle", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-390522:r:Striated Muscle Contraction", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-390522:r:Striated Muscle Contraction", "R-DME-114608:r:Platelet degranulation", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Domain"}, "IPR015154": {"description": "EF-hand domain, type 2", "go_ids": [], "go_terms": [], "name": "EF-hand_dom_typ2", "pathway_ids": ["R-DME-9035034", "R-CEL-9913351", "R-RNO-390522", "R-MMU-9913351", "R-DME-446388", "R-HSA-390522", "R-DME-114608", "R-MMU-390522", "R-HSA-9913351", "R-HSA-3000171", "R-HSA-9619665", "R-DME-9013418", "R-RNO-9913351"], "pathways": ["R-DME-9035034:r:RHOF GTPase cycle", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-390522:r:Striated Muscle Contraction", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-390522:r:Striated Muscle Contraction", "R-DME-114608:r:Platelet degranulation", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Domain"}, "IPR015155": {"description": "PLAA family ubiquitin binding domain", "go_ids": [], "go_terms": [], "name": "PFU", "pathway_ids": ["R-SPO-983168", "R-SPO-8951664", "R-SCE-983168"], "pathways": ["R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-8951664:r:Neddylation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR015156": {"description": "Malto-oligosyltrehalose trehalohydrolase, archaeal, C-terminal", "go_ids": [], "go_terms": [], "name": "Maltooligo_trehalose_arc_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015157": {"description": "Translation machinery associated TMA7", "go_ids": [], "go_terms": [], "name": "TMA7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015158": {"description": "Bud22 domain", "go_ids": [], "go_terms": [], "name": "Bud22_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015159": {"description": "Recombination protein 107", "go_ids": ["GO:0000794", "GO:0007131"], "go_terms": ["GO:0000794:condensed nuclear chromosome:C", "GO:0007131:reciprocal meiotic recombination:P"], "name": "Rec107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015160": {"description": "Heat-stable enterotoxin B, secretory", "go_ids": [], "go_terms": [], "name": "STb_secrete", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015161": {"description": "Streptomyces killer toxin-like, beta/gamma crystallin", "go_ids": [], "go_terms": [], "name": "Sklp_toxin_b/g_crystallin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015162": {"description": "CheY binding", "go_ids": [], "go_terms": [], "name": "CheY-binding", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015163": {"description": "Cdc6, C-terminal", "go_ids": [], "go_terms": [], "name": "Cdc6_C", "pathway_ids": ["R-RNO-68949", "R-HSA-68949", "R-RNO-68962", "R-HSA-69205", "R-HSA-113507", "R-MMU-69017", "R-MMU-68949", "R-RNO-176187", "R-SCE-69017", "R-DME-68962", "R-HSA-68616", "R-RNO-68616", "R-HSA-68962", "R-SCE-176187", "R-HSA-176187", "R-DME-68949", "R-RNO-68689", "R-HSA-68867", "R-DME-176187", "R-SPO-176187", "R-MMU-68962", "R-SPO-69017", "R-HSA-68689", "R-SCE-68962", "R-DME-68616", "R-DME-68689", "R-HSA-1362277", "R-SPO-68689", "R-SCE-68689", "R-HSA-69017", "R-MMU-176187", "R-MMU-68689", "R-SPO-68962", "R-MMU-68616", "R-SPO-68949"], "pathways": ["R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-68949:r:Orc1 removal from chromatin", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-SCE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-68962:r:Activation of the pre-replicative complex", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin"], "type": "Domain"}, "IPR015164": {"description": "K cyclin, C-terminal", "go_ids": [], "go_terms": [], "name": "K-cyclin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015165": {"description": "Glucan 1,4-alpha-maltotetraohydrolase, domain C", "go_ids": [], "go_terms": [], "name": "AMT4_domain_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015166": {"description": "Domain of unknown function DUF1922", "go_ids": [], "go_terms": [], "name": "DUF1922", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015167": {"description": "Domain of unknown function DUF1923", "go_ids": [], "go_terms": [], "name": "DUF1923", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015168": {"description": "SsuA/THI5-like", "go_ids": [], "go_terms": [], "name": "SsuA/THI5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015169": {"description": "Adhesion molecule, immunoglobulin-like", "go_ids": ["GO:0007155", "GO:0016020"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0016020:membrane:C"], "name": "Adhes-Ig-like", "pathway_ids": ["R-HSA-198933", "R-MMU-198933", "R-HSA-216083", "R-RNO-216083", "R-RNO-198933", "R-MMU-216083"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-216083:r:Integrin cell surface interactions"], "type": "Domain"}, "IPR015170": {"description": "Protein of unknown function DUF1924, Cytochrome c-type protein SHP-like", "go_ids": [], "go_terms": [], "name": "DUF1924_SHP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015171": {"description": "Cyclomaltodextrinase, N-terminal", "go_ids": [], "go_terms": [], "name": "Cyc-maltodext_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015172": {"description": "MIF4G-like, type 1", "go_ids": ["GO:0016070"], "go_terms": ["GO:0016070:RNA metabolic process:P"], "name": "MIF4G-like_typ-1", "pathway_ids": ["R-XTR-975957", "R-GGA-9930044", "R-SCE-975957", "R-XTR-6803529", "R-HSA-167152", "R-HSA-77588", "R-HSA-113418", "R-HSA-111367", "R-HSA-9918481", "R-RNO-6803529", "R-SPO-72203", "R-SCE-72203", "R-RNO-72086", "R-DME-975956", "R-GGA-72165", "R-GGA-6807505", "R-SCE-113418", "R-SCE-72086", "R-GGA-77595", "R-GGA-975957", "R-DME-159230", "R-DDI-77588", "R-RNO-77588", "R-XTR-6807505", "R-CEL-6803529", "R-SPO-674695", "R-HSA-6807505", "R-GGA-112382", "R-CEL-72165", "R-MMU-77588", "R-MMU-9770562", "R-GGA-73856", "R-CEL-159227", "R-CEL-72203", "R-HSA-9010553", "R-HSA-73856", "R-XTR-159236", "R-RNO-72163", "R-DME-72163", "R-SPO-975957", "R-SPO-9930044", "R-DDI-72163", "R-HSA-167158", "R-XTR-113418", "R-MMU-112382", "R-RNO-73856", "R-CEL-975956", "R-DME-72203", "R-DME-72086", "R-DDI-674695", "R-CEL-9770562", "R-GGA-159236", "R-DME-73856", "R-MMU-9930044", "R-XTR-674695", "R-SPO-159236", "R-GGA-159227", "R-XTR-77588", "R-MMU-72163", "R-SCE-77595", "R-HSA-6803529", "R-HSA-167242", "R-HSA-8851708", "R-HSA-159231", "R-CEL-674695", "R-HSA-72163", "R-MMU-159227", "R-MMU-111367", "R-DDI-113418", "R-MMU-72086", "R-GGA-975956", "R-HSA-191859", "R-SPO-159227", "R-XTR-9770562", "R-MMU-77595", "R-RNO-77595", "R-DDI-111367", "R-RNO-9930044", "R-CEL-77595", "R-HSA-159227", "R-HSA-77595", "R-DME-9770562", "R-GGA-72086", "R-GGA-72163", "R-XTR-77595", "R-RNO-159236", "R-HSA-72165", "R-GGA-9770562", "R-CEL-72163", "R-MMU-159231", "R-MMU-975956", "R-RNO-113418", "R-DME-113418", "R-XTR-111367", "R-HSA-72203", "R-XTR-73856", "R-HSA-9770562", "R-MMU-975957", "R-XTR-72203", "R-RNO-159227", "R-RNO-111367", "R-HSA-975957", "R-MMU-72187", "R-DDI-77595", "R-MMU-72165", "R-RNO-159231", "R-RNO-9770562", "R-HSA-674695", "R-DDI-975957", "R-XTR-72086", "R-SPO-72163", "R-DME-975957", "R-HSA-112382", "R-CEL-159236", "R-CEL-159231", "R-MMU-72203", "R-RNO-6807505", "R-CEL-975957", "R-RNO-674695", "R-MMU-113418", "R-HSA-72187", "R-DME-9930044", "R-MMU-159230", "R-HSA-975956", "R-HSA-159230", "R-RNO-159230", "R-CEL-159230", "R-RNO-72165", "R-SPO-72086", "R-GGA-159230", "R-RNO-975957", "R-SPO-113418", "R-SPO-975956", "R-CEL-6807505", "R-DME-674695", "R-RNO-72203", "R-SCE-975956", "R-MMU-73856", "R-DDI-72203", "R-XTR-112382", "R-CEL-113418", "R-DDI-72086", "R-DME-159227", "R-SPO-77595", "R-MMU-674695", "R-MMU-6807505", "R-MMU-159236", "R-GGA-111367", "R-DDI-6807505", "R-DME-6807505", "R-SPO-9770562", "R-HSA-167200", "R-XTR-9930044", "R-DME-72165", "R-RNO-112382", "R-RNO-975956", "R-SCE-674695", "R-CEL-9930044", "R-HSA-159236", "R-DME-77588", "R-CEL-77588", "R-DDI-9930044", "R-DME-111367", "R-MMU-6803529", "R-GGA-77588", "R-DDI-975956", "R-CEL-111367", "R-HSA-9930044", "R-DME-77595", "R-SPO-159231", "R-GGA-674695", "R-DME-159236", "R-DME-159231", "R-CEL-72086", "R-HSA-72086", "R-CEL-73856", "R-DDI-9770562", "R-XTR-72163", "R-XTR-975956", "R-XTR-72165", "R-DDI-73856"], "pathways": ["R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-GGA-9930044:r:Nuclear RNA decay", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-6803529:r:FGFR2 alternative splicing", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-72086:r:mRNA Capping", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-GGA-72165:r:mRNA Splicing - Minor Pathway", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-GGA-77595:r:Processing of Intronless Pre-mRNAs", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DDI-77588:r:SLBP Dependent 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Intron-Containing Pre-mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DDI-72086:r:mRNA Capping", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-GGA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-XTR-9930044:r:Nuclear RNA decay", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DDI-9930044:r:Nuclear RNA decay", "R-DME-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-GGA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-9930044:r:Nuclear RNA decay", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-GGA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-XTR-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-GGA-9930044:r:Nuclear RNA decay", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-6803529:r:FGFR2 alternative splicing", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-72086:r:mRNA Capping", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-GGA-72165:r:mRNA Splicing - Minor Pathway", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-GGA-77595:r:Processing of Intronless Pre-mRNAs", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DDI-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-RNO-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Domain"}, "IPR015176": {"description": "Lyase, N-terminal", "go_ids": [], "go_terms": [], "name": "Lyase_N", "pathway_ids": ["PWY-7646", "PWY-6572"], "pathways": ["PWY-7646:t:dermatan sulfate degradation I (bacterial)", "PWY-6572:t:chondroitin sulfate degradation I (bacterial)"], "type": "Domain"}, "IPR015177": {"description": "Lyase, catalytic", "go_ids": [], "go_terms": [], "name": "Lyase_catalyt", "pathway_ids": ["PWY-7646", "PWY-6572"], "pathways": ["PWY-7646:t:dermatan sulfate degradation I (bacterial)", "PWY-6572:t:chondroitin sulfate degradation I (bacterial)"], "type": "Domain"}, "IPR015178": {"description": "Alpha-amylase/4-alpha-glucanotransferase, central domain", "go_ids": [], "go_terms": [], "name": "A-amylase/a-glucTrfase_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015179": {"description": "Alpha-amylase/4-alpha-glucanotransferase, C-terminal", "go_ids": ["GO:0003824", "GO:0005975", "GO:0030246"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0005975:carbohydrate metabolic process:P", "GO:0030246:carbohydrate binding:F"], "name": "A-amylase/a-glucTrfase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015180": {"description": "Bacteriophage T4, Gp27, baseplate hub, C-terminal", "go_ids": ["GO:0098025"], "go_terms": ["GO:0098025:virus tail, baseplate:C"], "name": "Phage_T4_Gp27_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015181": {"description": "Bacteriophage T4, Gp27, baseplate hub, N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp27_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015182": {"description": "Quinohemoprotein amine dehydrogenase, alpha subunit, haem binding domain", "go_ids": [], "go_terms": [], "name": "QH-AmDH_asu_heme-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015183": {"description": "Quinohemoprotein amine dehydrogenase, alpha subunit domain III", "go_ids": [], "go_terms": [], "name": "QH-AmDH_asu_dom_III", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015184": {"description": "Quinohemoprotein amine dehydrogenase, alpha subunit domain IV", "go_ids": [], "go_terms": [], "name": "QH-AmDH_asu_dom_IV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015185": {"description": "Exotoxin A, binding", "go_ids": [], "go_terms": [], "name": "Exotox-A_bind", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015186": {"description": "Exotoxin A, middle domain", "go_ids": [], "go_terms": [], "name": "Exotox-A_middle_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015187": {"description": "BRCA2, OB1", "go_ids": ["GO:0000724"], "go_terms": ["GO:0000724:double-strand break repair via homologous recombination:P"], "name": "BRCA2_OB_1", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-RNO-5693579", "R-HSA-9704646", "R-RNO-5685939", "R-HSA-9709603", "R-MMU-5693616", "R-MMU-5685942", "R-HSA-5685939", "R-HSA-9709275", "R-RNO-5685942", "R-HSA-9709570", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-912446", "R-HSA-9763198", "R-MMU-5685939", "R-MMU-5693568", "R-RNO-5693616", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709275:r:Impaired BRCA2 translocation to the nucleus", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-912446:r:Meiotic recombination", "R-HSA-9763198:r:Impaired BRCA2 binding to SEM1 (DSS1)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR015188": {"description": "BRCA2, OB3", "go_ids": [], "go_terms": [], "name": "BRCA2_OB_3", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-RNO-5693579", "R-HSA-9704646", "R-RNO-5685939", "R-HSA-9709603", "R-MMU-5693616", "R-MMU-5685942", "R-HSA-5685939", "R-HSA-9709275", "R-RNO-5685942", "R-HSA-9709570", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-912446", "R-HSA-9763198", "R-MMU-5685939", "R-MMU-5693568", "R-RNO-5693616", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709275:r:Impaired BRCA2 translocation to the nucleus", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-912446:r:Meiotic recombination", "R-HSA-9763198:r:Impaired BRCA2 binding to SEM1 (DSS1)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR015189": {"description": "Translation elongation factor SelB, winged helix, type 1", "go_ids": [], "go_terms": [], "name": "Elong_fac_SelB-wing-hlx_typ-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015190": {"description": "Translation elongation factor SelB, winged helix, type 2", "go_ids": ["GO:0001514", "GO:0003723", "GO:0003746", "GO:0005525", "GO:0005737"], "go_terms": ["GO:0001514:selenocysteine incorporation:P", "GO:0003723:RNA binding:F", "GO:0003746:translation elongation factor activity:F", "GO:0005525:GTP binding:F", "GO:0005737:cytoplasm:C"], "name": "Elong_fac_SelB-wing-hlx_typ-2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015191": {"description": "Elongation factor SelB, fourth winged-helix domain", "go_ids": ["GO:0001514", "GO:0003723", "GO:0003746", "GO:0005525", "GO:0005737"], "go_terms": ["GO:0001514:selenocysteine incorporation:P", "GO:0003723:RNA binding:F", "GO:0003746:translation elongation factor activity:F", "GO:0005525:GTP binding:F", "GO:0005737:cytoplasm:C"], "name": "SelB_WHD4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015192": {"description": "Switch protein XOL-1, N-terminal", "go_ids": [], "go_terms": [], "name": "Xol-1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015193": {"description": "Switch protein XOL-1, GHMP-like", "go_ids": [], "go_terms": [], "name": "Xol-1_GHMP-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015194": {"description": "ISWI, HAND domain", "go_ids": ["GO:0031491", "GO:0006338", "GO:0003677"], "go_terms": ["GO:0031491:nucleosome binding:F", "GO:0006338:chromatin remodeling:P", "GO:0003677:DNA binding:F"], "name": "ISWI_HAND-dom", "pathway_ids": ["PWY-7250", "R-MMU-5693565", "R-HSA-606279", "R-MMU-606279", "R-MMU-5250924", "R-HSA-5693565", "R-HSA-427413", "R-HSA-5250924"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression"], "type": "Domain"}, "IPR015195": {"description": "SLIDE domain", "go_ids": ["GO:0003677", "GO:0005634", "GO:0006338"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006338:chromatin remodeling:P"], "name": "SLIDE", "pathway_ids": ["PWY-7250", "R-MMU-5693565", "R-HSA-606279", "R-MMU-606279", "R-MMU-5250924", "R-HSA-5693565", "R-HSA-427413", "R-HSA-5250924"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression"], "type": "Domain"}, "IPR015196": {"description": "Peptide-N-glycosidase F, N-terminal", "go_ids": [], "go_terms": [], "name": "PngaseF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015197": {"description": "Peptide-N-glycosidase F, C-terminal", "go_ids": [], "go_terms": [], "name": "PngaseF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015198": {"description": "Bacteriophage T4, MotA, transcription regulator N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_T4_MotA_Tscrpt_reg_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015199": {"description": "DNA polymerase III, delta subunit, C-terminal", "go_ids": ["GO:0003677", "GO:0003887", "GO:0006260", "GO:0009360"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P", "GO:0009360:DNA polymerase III complex:C"], "name": "DNA_pol_III_delta_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015200": {"description": "Sliding clamp, C-terminal", "go_ids": ["GO:0039693"], "go_terms": ["GO:0039693:viral DNA genome replication:P"], "name": "Sliding_clamp_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015201": {"description": "Antimicrobial protein MiAMP1", "go_ids": ["GO:0006952", "GO:0045926"], "go_terms": ["GO:0006952:defense response:P", "GO:0045926:negative regulation of growth:P"], "name": "Antimicrobial_MiAMP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015202": {"description": "Galactose oxidase-like, Early set domain", "go_ids": [], "go_terms": [], "name": "GO-like_E_set", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015203": {"description": "Secreted effector protein SptP, N-terminal domain", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "SptP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015205": {"description": "Tower domain", "go_ids": [], "go_terms": [], "name": "Tower_dom", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-RNO-5693579", "R-HSA-9704646", "R-RNO-5685939", "R-HSA-9709603", "R-MMU-5693616", "R-MMU-5685942", "R-HSA-5685939", "R-HSA-9709275", "R-RNO-5685942", "R-HSA-9709570", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-912446", "R-HSA-9763198", "R-MMU-5685939", "R-MMU-5693568", "R-RNO-5693616", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709275:r:Impaired BRCA2 translocation to the nucleus", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-912446:r:Meiotic recombination", "R-HSA-9763198:r:Impaired BRCA2 binding to SEM1 (DSS1)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR015206": {"description": "3-mercaptopyruvate sulfurtransferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SulfurTase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015207": {"description": "Protein of unknown function DUF1931", "go_ids": [], "go_terms": [], "name": "DUF1931", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015208": {"description": "T4 recombination endonuclease VII, dimerisation", "go_ids": [], "go_terms": [], "name": "T4_recomb_endonuclease_dimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015209": {"description": "Cytochrome C oxidase subunit IIa, transmembrane domain", "go_ids": [], "go_terms": [], "name": "Cyt_c_oxidase_su2a_TM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015210": {"description": "Type II restriction enzyme NaeI", "go_ids": ["GO:0009036", "GO:0009307"], "go_terms": ["GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "NaeI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015211": {"description": "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal", "go_ids": ["GO:0008237", "GO:0008270"], "go_terms": ["GO:0008237:metallopeptidase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Peptidase_M1_C", 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"R-DDI-9018676", "R-SCE-9018681", "R-BTA-9018676", "R-RNO-9020265", "R-RNO-6798695", "R-MMU-9018896"], "pathways": ["PWY-6423:t:hemoglobin degradation", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8356:t:maresin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-6710:t:poly-hydroxy fatty acids biosynthesis", "PWY-7778:t:2-methylpropene degradation", "PWY-8400:t:docosahexaenoate metabolites biosynthesis", "PWY-8395:t:linoleate metabolites biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9018681:r:Biosynthesis of protectins", "R-HSA-9018676:r:Biosynthesis of D-series resolvins", "R-SCE-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-9018681:r:Biosynthesis of protectins", "R-RNO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-9018681:r:Biosynthesis of protectins", "R-BTA-6798695:r:Neutrophil degranulation", "R-SCE-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SPO-9018681:r:Biosynthesis of protectins", "R-CEL-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-CEL-9018681:r:Biosynthesis of protectins", "R-BTA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SPO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DDI-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SCE-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DDI-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SCE-9018676:r:Biosynthesis of D-series resolvins", "R-BTA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-CEL-9018676:r:Biosynthesis of D-series resolvins", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-DDI-9018681:r:Biosynthesis of protectins", "R-SPO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-9018676:r:Biosynthesis of D-series resolvins", "R-DDI-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-DDI-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SPO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9018681:r:Biosynthesis of protectins", "R-DDI-9018676:r:Biosynthesis of D-series resolvins", "R-SCE-9018681:r:Biosynthesis of protectins", "R-BTA-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins"], "type": "Domain"}, "IPR015212": {"description": "Regulator of G protein signalling-like domain", "go_ids": ["GO:0005085", "GO:0005737"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0005737:cytoplasm:C"], "name": "RGS-like_dom", "pathway_ids": ["R-RNO-9013026", "R-HSA-193648", "R-CFA-9013148", "R-HSA-416572", "R-CFA-8980692", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-HSA-416482", "R-RNO-416572", "R-RNO-9013149", "R-HSA-9013106", "R-MMU-9013148", "R-RNO-9013148", "R-MMU-416572", "R-HSA-9013149", "R-HSA-8980692", "R-CFA-9013106", "R-CFA-193648", "R-RNO-416482", "R-MMU-9013026", "R-MMU-416482", "R-HSA-9013148", "R-MMU-193648", "R-HSA-9013026", "R-CFA-416572", "R-RNO-9013106", "R-RNO-193648", "R-CFA-416482"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-193648:r:NRAGE signals death through JNK", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CFA-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-CFA-193648:r:NRAGE signals death through JNK", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-193648:r:NRAGE signals death through JNK", "R-CFA-416482:r:G alpha (12/13) signalling events"], "type": "Domain"}, "IPR015213": {"description": "Cholesterol oxidase, substrate-binding", "go_ids": [], "go_terms": [], "name": "Cholesterol_OX_subst-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015214": {"description": "Pesticidal crystal protein, central domain, Cry2A/18", "go_ids": [], "go_terms": [], "name": "Pest_cryst_cen_dom_Cry2A/18", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015215": {"description": "BmKX domain", "go_ids": [], "go_terms": [], "name": "BmKX_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015216": {"description": "SANT associated", "go_ids": [], "go_terms": [], "name": "SANTA", "pathway_ids": ["R-CEL-69273", "R-HSA-69273", "R-HSA-606279", "R-MMU-606279", "R-MMU-69273"], "pathways": ["R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition"], "type": "Domain"}, "IPR015217": {"description": "Invasin, domain 3", "go_ids": [], "go_terms": [], "name": "Invasin_dom_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015220": {"description": "Glucodextranase, N-terminal", "go_ids": [], "go_terms": [], "name": "Glucodextranase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015221": {"description": "Ubiquitin-related modifier 1", "go_ids": ["GO:0005737", "GO:0034227"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0034227:tRNA thio-modification:P"], "name": "Urm1", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR015222": {"description": "Phosphatidate cytidylyltransferase, mitochondrial", "go_ids": ["GO:0032049", "GO:0004605"], "go_terms": ["GO:0032049:cardiolipin biosynthetic process:P", "GO:0004605:phosphatidate cytidylyltransferase activity:F"], "name": "Tam41", "pathway_ids": ["PWY-5981", "PWY-7817", "PWY-5667"], "pathways": ["PWY-5981:t:CDP-diacylglycerol biosynthesis III", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-5667:t:CDP-diacylglycerol biosynthesis I"], "type": "Family"}, "IPR015223": {"description": "ATPase MipZ", "go_ids": [], "go_terms": [], "name": "MipZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015224": {"description": "Talin, central", "go_ids": ["GO:0001726", "GO:0005200", "GO:0005925"], "go_terms": ["GO:0001726:ruffle:C", "GO:0005200:structural constituent of cytoskeleton:F", "GO:0005925:focal adhesion:C"], "name": "Talin_cent", "pathway_ids": ["R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-9656223", "R-MMU-399955", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR015225": {"description": "tRNA pseudouridine synthase II, TruB, subfamily 2, C-terminal", "go_ids": ["GO:0001522", "GO:0003723", "GO:0009451", "GO:0009982"], "go_terms": ["GO:0001522:pseudouridine synthesis:P", "GO:0003723:RNA binding:F", "GO:0009451:RNA modification:P", "GO:0009982:pseudouridine synthase activity:F"], "name": "tRNA_psdUridine_synth_fam2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015226": {"description": "Type III effector HopF2", "go_ids": [], "go_terms": [], "name": "T3_effector_HopF2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015227": {"description": "Mitogen, Yersinia pseudotuberculosis", "go_ids": [], "go_terms": [], "name": "Mitogen_YERPS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015228": {"description": "SWA2-like, ubiquitin-associated domain", "go_ids": [], "go_terms": [], "name": "SWA2_UBA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015230": {"description": "Carbapenam-3-carboxylate synthase, N-terminal", "go_ids": [], "go_terms": [], "name": "CarA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015231": {"description": "Protein of unknown function DUF1934", "go_ids": [], "go_terms": [], "name": "DUF1934", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015232": {"description": "Domain of unknown function DUF1935", "go_ids": [], "go_terms": [], "name": "DUF1935", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015233": {"description": "Orange carotenoid-binding protein, N-terminal", "go_ids": ["GO:0016037", "GO:0030089", "GO:0031404"], "go_terms": ["GO:0016037:light absorption:P", "GO:0030089:phycobilisome:C", "GO:0031404:chloride ion binding:F"], "name": "Orange_carotenoid-bd_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015234": {"description": "Domain of unknown function DUF1936", "go_ids": [], "go_terms": [], "name": "DUF1936", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015235": {"description": "Domain of unknown function DUF1937", "go_ids": [], "go_terms": [], "name": "DUF1937", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015236": {"description": "Methylated DNA-protein cysteine methyltransferase, ribonuclease H-like domain", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "MGMT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015237": {"description": "Alpha-amylase C-terminal, prokaryotic", "go_ids": ["GO:0004553"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "Alpha-amylase_C_pro", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015238": {"description": "Protein of unknown function DUF1940", "go_ids": [], "go_terms": [], "name": "DUF1940", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015239": {"description": "Anthrax toxin lethal factor, central domain", "go_ids": [], "go_terms": [], "name": "Anthrax_LF_cen", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Domain"}, "IPR015240": {"description": "tRNA pseudouridine synthase II, TruB, subfamily 1, C-terminal", "go_ids": ["GO:0001522", "GO:0003723", "GO:0009451", "GO:0009982"], "go_terms": ["GO:0001522:pseudouridine synthesis:P", "GO:0003723:RNA binding:F", "GO:0009451:RNA modification:P", "GO:0009982:pseudouridine synthase activity:F"], "name": "tRNA_sdUridine_synth_fam1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015241": {"description": "Transcription regulator MotA, C-terminal", "go_ids": [], "go_terms": [], "name": "MotA_Tscrpt_reg_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015242": {"description": "Mitochondrial resolvase Ydc2, catalytic", "go_ids": [], "go_terms": [], "name": "Ydc2_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015243": {"description": "FimH, mannose-binding domain", "go_ids": [], "go_terms": [], "name": "FimH_man-bd", "pathway_ids": ["R-HSA-9638630"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells"], "type": "Domain"}, "IPR015245": {"description": "Nuclear RNA export factor Tap, RNA-binding domain", "go_ids": ["GO:0003723", "GO:0005737", "GO:0006406"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005737:cytoplasm:C", "GO:0006406:mRNA export from nucleus:P"], "name": "Tap_RNA-bd", "pathway_ids": ["R-CEL-159231", "R-BTA-159230", "R-CEL-159227", "R-DME-159236", "R-DME-159231", "R-DME-159227", "R-RNO-159227", "R-BTA-159227", "R-MMU-159236", "R-MMU-159230", "R-DME-159230", "R-HSA-159230", "R-HSA-159231", "R-RNO-159230", "R-MMU-159227", "R-HSA-159227", "R-CEL-159230", "R-RNO-159231", "R-RNO-159236", "R-BTA-159236", "R-BTA-159231", "R-HSA-159236", "R-MMU-159231", "R-CEL-159236"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR015246": {"description": "Formate dehydrogenase, transmembrane", "go_ids": [], "go_terms": [], "name": "Formate_DH_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015247": {"description": "Vitamin D binding protein, domain III", "go_ids": [], "go_terms": [], "name": "VitD-bind_III", "pathway_ids": ["R-RNO-196791", "R-MMU-196791", "R-HSA-196791"], "pathways": ["R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-196791:r:Vitamin D (calciferol) metabolism"], "type": "Domain"}, "IPR015248": {"description": "Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal", "go_ids": ["GO:0008121"], "go_terms": ["GO:0008121:quinol-cytochrome-c reductase activity:F"], "name": "UQCRFS1_N", "pathway_ids": ["PWY-7279", "PWY-6692", "PWY-3781", "R-RNO-611105", "R-HSA-611105", "R-HSA-9865881", "R-MMU-611105", "R-DRE-9865881", "R-BTA-9865881", "R-RNO-9865881", "R-GGA-9865881", "R-CEL-9865881", "R-DME-9865881", "R-SSC-9865881", "R-BTA-611105", "R-MMU-9865881"], "pathways": ["PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "PWY-6692:t:Fe(II) oxidation", "PWY-3781:t:aerobic respiration I (cytochrome c)", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-9865881:r:Complex III assembly", "R-MMU-611105:r:Respiratory electron transport", "R-DRE-9865881:r:Complex III assembly", "R-BTA-9865881:r:Complex III assembly", "R-RNO-9865881:r:Complex III assembly", "R-GGA-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-9865881:r:Complex III assembly", "R-SSC-9865881:r:Complex III assembly", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR015249": {"description": "Biliverdin reductase, catalytic", "go_ids": ["GO:0004074", "GO:0008270", "GO:0042167"], "go_terms": ["GO:0004074:biliverdin reductase [NAD(P)H] activity:F", "GO:0008270:zinc ion binding:F", "GO:0042167:heme catabolic process:P"], "name": "Biliverdin_Rdtase_cat", "pathway_ids": ["PWY-5874", "R-MMU-189483", "R-RNO-9707564", "R-HSA-189483", "R-RNO-189483", "R-MMU-9707564", "R-HSA-9707564"], "pathways": ["PWY-5874:t:heme degradation I", "R-MMU-189483:r:Heme degradation", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-189483:r:Heme degradation", "R-RNO-189483:r:Heme degradation", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR015250": {"description": "MPT63-like", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "MPT63-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015251": {"description": "X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain", "go_ids": ["GO:0006508", "GO:0008239"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008239:dipeptidyl-peptidase activity:F"], "name": "PepX_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015252": {"description": "Breast cancer type 2 susceptibility protein, helical domain", "go_ids": [], "go_terms": [], "name": "BRCA2_hlx", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-RNO-5693579", "R-HSA-9704646", "R-RNO-5685939", "R-HSA-9709603", "R-MMU-5693616", "R-MMU-5685942", "R-HSA-5685939", "R-HSA-9709275", "R-RNO-5685942", "R-HSA-9709570", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-912446", "R-HSA-9763198", "R-MMU-5685939", "R-MMU-5693568", "R-RNO-5693616", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709275:r:Impaired BRCA2 translocation to the nucleus", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-912446:r:Meiotic recombination", "R-HSA-9763198:r:Impaired BRCA2 binding to SEM1 (DSS1)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR015253": {"description": "Stn1, C-terminal", "go_ids": [], "go_terms": [], "name": "CST_STN1_C", "pathway_ids": ["R-BTA-174411", "R-MMU-174430", "R-BTA-174430", "R-RNO-174430", "R-DRE-174430", "R-HSA-174430", "R-MMU-174411", "R-HSA-174411", "R-RNO-174411"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere"], "type": "Domain"}, "IPR015254": {"description": "N-glycosylase/DNA lyase-like", "go_ids": ["GO:0016799", "GO:0003906"], "go_terms": ["GO:0016799:hydrolase activity, hydrolyzing N-glycosyl compounds:F", "GO:0003906:DNA-(apurinic or apyrimidinic site) endonuclease activity:F"], "name": "AGOG-like", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Family"}, "IPR015255": {"description": "Vitellinogen, open beta-sheet", "go_ids": ["GO:0005319", "GO:0006869"], "go_terms": ["GO:0005319:lipid carrier activity:F", "GO:0006869:lipid transport:P"], "name": "Vitellinogen_open_b-sht", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-HSA-8964038", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-RNO-5686938", "R-MMU-3000471", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-HSA-8957275", "R-RNO-3000480", "R-HSA-202733", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964038:r:LDL clearance", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR015256": {"description": "Initiation factor eIF2 gamma, C-terminal", "go_ids": [], "go_terms": [], "name": "eIF2g_C", "pathway_ids": ["R-MMU-72706", "R-BTA-72695", "R-BTA-381042", "R-BTA-72731", "R-DRE-9840373", "R-SCE-72695", "R-SCE-72702", "R-BTA-9840373", "R-MMU-72695", "R-HSA-9840373", "R-DRE-156827", "R-SCE-156827", "R-DME-72695", "R-BTA-156827", "R-MMU-382556", "R-RNO-156827", "R-DRE-72695", "R-SPO-72706", "R-SPO-72649", "R-DME-72731", "R-SPO-72695", "R-DDI-72695", "R-HSA-382556", "R-SPO-9840373", "R-BTA-72702", "R-HSA-72706", "R-RNO-72731", "R-RNO-72702", "R-RNO-381042", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-DME-9840373", "R-RNO-72649", "R-SCE-9840373", "R-HSA-9648895", "R-DRE-72649", "R-DDI-9840373", "R-SCE-72649", "R-DRE-72702", "R-DDI-72731", "R-SPO-156827", "R-DDI-381042", "R-DME-72702", "R-BTA-72649", "R-DDI-156827", "R-DDI-72702", "R-MMU-9840373", "R-HSA-9633012", "R-HSA-72731", "R-DRE-382556", "R-SCE-382556", "R-SPO-72702", "R-SPO-382556", "R-DME-156827", "R-DDI-382556", "R-BTA-382556", "R-HSA-9833482", "R-DME-382556", "R-HSA-381042", "R-SPO-72731", "R-RNO-9840373", "R-RNO-382556", "R-DME-72649", "R-HSA-156827", "R-DME-381042", "R-RNO-72695", "R-DRE-72731", "R-HSA-72695", "R-MMU-381042", "R-MMU-72649", "R-DRE-381042", "R-SCE-72731", "R-MMU-72702", "R-MMU-72731"], "pathways": ["R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-381042:r:PERK regulates gene expression", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-DRE-9840373:r:Cellular response to mitochondrial stress", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-9840373:r:Cellular response to mitochondrial stress", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-DME-72731:r:Recycling of eIF2:GDP", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-381042:r:PERK regulates gene expression", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-9840373:r:Cellular response to mitochondrial stress", "R-RNO-72649:r:Translation initiation complex formation", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-DRE-72649:r:Translation initiation complex formation", "R-DDI-9840373:r:Cellular response to mitochondrial stress", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-381042:r:PERK regulates gene expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-SPO-72702:r:Ribosomal 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"R-MMU-381042:r:PERK regulates gene expression", "R-MMU-72649:r:Translation initiation complex formation", "R-DRE-381042:r:PERK regulates gene expression", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72731:r:Recycling of eIF2:GDP"], "type": "Domain"}, "IPR015257": {"description": "Repressor of RNA polymerase III transcription Maf1", "go_ids": ["GO:0016480"], "go_terms": ["GO:0016480:negative regulation of transcription by RNA polymerase III:P"], "name": "Maf1", "pathway_ids": ["R-DDI-8943724", "R-RNO-8943724", "R-SCE-8943724", "R-SPO-8943724", "R-MMU-8943724", "R-HSA-8943724", "R-BTA-8943724"], "pathways": ["R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-SCE-8943724:r:Regulation of PTEN gene transcription", "R-SPO-8943724:r:Regulation of PTEN gene transcription", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-8943724:r:Regulation of 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[], "name": "DUF1947", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015267": {"description": "Protein phosphatase 4 core regulatory subunit R2", "go_ids": ["GO:0030289", "GO:0019888"], "go_terms": ["GO:0030289:protein phosphatase 4 complex:C", "GO:0019888:protein phosphatase regulator activity:F"], "name": "PPP4R2", "pathway_ids": ["R-DRE-5693607", "R-HSA-5693607", "R-MMU-5693607"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Family"}, "IPR015268": {"description": "Protein of unknown function DUF1948", "go_ids": [], "go_terms": [], "name": "DUF1948", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015269": {"description": "Uncharacterised domain UPF0029, Impact, C-terminal", "go_ids": [], "go_terms": [], "name": "UPF0029_Impact_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015270": {"description": "Protein RDM1, plant", "go_ids": ["GO:0080188", "GO:0005634"], "go_terms": ["GO:0080188:gene silencing by siRNA-directed DNA methylation:P", "GO:0005634:nucleus:C"], "name": "RDM1_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015271": {"description": "Protein of unknown function DUF1951", "go_ids": [], "go_terms": [], "name": "DUF1951", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015272": {"description": "Molybdopterin cofactor biosynthesis MoaD-related, C-terminal", "go_ids": [], "go_terms": [], "name": "MoadD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015273": {"description": "Cysteinyl-tRNA synthetase, class Ia, DALR", "go_ids": ["GO:0000166", "GO:0004817", "GO:0005524", "GO:0005737", "GO:0006423"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004817:cysteine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006423:cysteinyl-tRNA aminoacylation:P"], "name": 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"IPR015309": {"description": "Transcriptional repressor TraM", "go_ids": ["GO:0045892"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "Tscrpt_rep_TraM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015310": {"description": "Activator of Hsp90 ATPase AHSA1-like, N-terminal", "go_ids": ["GO:0001671", "GO:0051087"], "go_terms": ["GO:0001671:ATPase activator activity:F", "GO:0051087:protein-folding chaperone binding:F"], "name": "AHSA1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015311": {"description": "DNA fragmentation factor 40, C-terminal", "go_ids": ["GO:0005634", "GO:0005737", "GO:0006309", "GO:0016787"], "go_terms": ["GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C", "GO:0006309:apoptotic DNA fragmentation:P", "GO:0016787:hydrolase activity:F"], "name": "DFF40_C", "pathway_ids": ["R-HSA-140342", "R-MMU-140342", "R-RNO-140342"], "pathways": ["R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-140342:r:Apoptosis induced DNA fragmentation"], "type": "Domain"}, "IPR015312": {"description": "Inner layer core protein VP3, Phytoreovirus", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Innr_layr_core_VP3_Phytoreovir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015313": {"description": "Protein Her-1", "go_ids": [], "go_terms": [], "name": "Her-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015314": {"description": "Restriction endonuclease, type II, EcoRV", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_EcoRV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015315": {"description": "Domain of unknown function DUF1963", "go_ids": [], "go_terms": [], "name": "DUF1963", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015316": {"description": "Ste50, sterile alpha motif", "go_ids": [], "go_terms": [], "name": "SAM_Ste50", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015317": {"description": "Alpha-haemoglobin stabilising protein", "go_ids": ["GO:0006457", "GO:0030492", "GO:0050821", "GO:0030218"], "go_terms": ["GO:0006457:protein folding:P", "GO:0030492:hemoglobin binding:F", "GO:0050821:protein stabilization:P", "GO:0030218:erythrocyte differentiation:P"], "name": "A_Hb_stabilising_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015318": {"description": "Zinc finger, GAGA-binding factor", "go_ids": [], "go_terms": [], "name": "Znf_GAGA-bd_fac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015319": {"description": "Interleukin-4 receptor alpha, N-terminal", "go_ids": ["GO:0004896", "GO:0016020", "GO:0002532"], "go_terms": ["GO:0004896:cytokine receptor activity:F", "GO:0016020:membrane:C", "GO:0002532:production of molecular mediator involved in inflammatory response:P"], "name": "IL-4_rcpt-alpha_N", "pathway_ids": ["R-MMU-6785807", "R-RNO-6785807", "R-HSA-6785807"], "pathways": ["R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling"], "type": "Domain"}, "IPR015320": {"description": "DNA topoisomerase VI, subunit B, transducer", "go_ids": ["GO:0003677", "GO:0003918", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003918:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity:F", "GO:0006265:DNA topological change:P"], "name": "TopoVI_B_transducer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015321": {"description": "Type I cytokine receptor, cytokine-binding domain", "go_ids": [], "go_terms": [], "name": "TypeI_recpt_CBD", "pathway_ids": ["R-RNO-112411", "R-RNO-6785807", "R-HSA-1059683", "R-HSA-112411", "R-MMU-112411", "R-MMU-5673001", "R-RNO-1059683", "R-HSA-9679191", "R-HSA-6788467", "R-HSA-6785807", "R-HSA-110056", "R-HSA-5673001", "R-CFA-6785807", "R-MMU-912526", "R-MMU-1059683", "R-HSA-5688890", "R-HSA-5683826", "R-HSA-912526", "R-RNO-110056", "R-MMU-512988", "R-HSA-9616222", "R-HSA-512988", "R-MMU-110056", "R-MMU-6785807", "R-HSA-5688849"], "pathways": ["R-RNO-112411:r:MAPK1 (ERK2) activation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-1059683:r:Interleukin-6 signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-CFA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5"], "type": "Domain"}, "IPR015322": {"description": "Cyclin domain, herpesvirus", "go_ids": [], "go_terms": [], "name": "Cyclin_dom_herpesvir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015323": {"description": "Flavocytochrome c sulphide dehydrogenase, flavin-binding", "go_ids": ["GO:0050660", "GO:0016491"], "go_terms": ["GO:0050660:flavin adenine dinucleotide binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "FlavoCytC_S_DH_flav-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015324": {"description": "Ribosomal protein Rsm22-like", "go_ids": ["GO:0006412", "GO:0008168"], "go_terms": ["GO:0006412:translation:P", "GO:0008168:methyltransferase activity:F"], "name": "Ribosomal_Rsm22-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015325": {"description": "Sucrose phosphorylase, C-terminal", "go_ids": [], "go_terms": [], "name": "Suc_Porlyase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015326": {"description": "Mycoplasma arthritidis-derived mitogen", "go_ids": [], "go_terms": [], "name": "M_arthritidis-der_mitogen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015327": {"description": "Smaug, PHAT analogous topology", "go_ids": ["GO:0003723", "GO:0006355"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "PHAT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015328": {"description": "Domain of unknown function DUF1965", "go_ids": [], "go_terms": [], "name": "DUF1965", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015329": {"description": "tRNA nucleotidyltransferase, substrate binding", "go_ids": ["GO:0004810"], "go_terms": ["GO:0004810:CCA tRNA nucleotidyltransferase activity:F"], "name": "tRNA_NucTransf2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015330": {"description": "DNA primase/polymerase, bifunctional, N-terminal", "go_ids": [], "go_terms": [], "name": "DNA_primase/pol_bifunc_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015331": {"description": "P22 tailspike C-terminal domain", "go_ids": [], "go_terms": [], "name": "P22_tailspike_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015332": {"description": "Major allergen I polypeptide chain 2-like", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "CH2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015333": {"description": "Pollen allergen ole e 6", "go_ids": [], "go_terms": [], "name": "Pollen_allergen_ole-e-6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015334": {"description": "FokI, cleavage domain", "go_ids": ["GO:0009036", "GO:0009307"], "go_terms": ["GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "FokI_cleavage_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015336": {"description": "Tumour necrosis factor receptor 13C, TALL-1 binding domain", "go_ids": [], "go_terms": [], "name": "TNFR_13C_TALL-1-bd", "pathway_ids": ["R-HSA-5668541", "R-MMU-5668541", "R-MMU-5676594", "R-HSA-5676594"], "pathways": ["R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "type": "Domain"}, "IPR015337": {"description": "BCMA, TALL-1 binding", "go_ids": [], "go_terms": [], "name": "BCMA_Tall-1-bd", "pathway_ids": ["R-HSA-5669034", "R-MMU-5669034"], "pathways": ["R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Domain"}, "IPR015338": {"description": "Glycosyl transferase 64 domain", "go_ids": ["GO:0016757", "GO:0016020"], "go_terms": ["GO:0016757:glycosyltransferase activity:F", "GO:0016020:membrane:C"], "name": "GT64_dom", "pathway_ids": ["R-BTA-2022928", "R-HSA-381038", "R-CEL-2022928", "R-HSA-3656253", "R-DME-2022928", "R-DRE-2022928", "R-MMU-2022928", "R-HSA-2022928", "R-HSA-3656237"], "pathways": ["R-BTA-2022928:r:HS-GAG biosynthesis", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-DME-2022928:r:HS-GAG biosynthesis", "R-DRE-2022928:r:HS-GAG biosynthesis", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2"], "type": "Domain"}, "IPR015339": {"description": "Immunomodulatory protein FIP-Fve, fungal", "go_ids": ["GO:0002682", "GO:0030246"], "go_terms": ["GO:0002682:regulation of immune system process:P", "GO:0030246:carbohydrate binding:F"], "name": "Immunomodulatory_FIP-Fve_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015340": {"description": "Alpha-amylase, C domain", "go_ids": ["GO:0005509", "GO:0016052"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0016052:carbohydrate catabolic process:P"], "name": "A_amylase_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015341": {"description": "Glycoside hydrolase family 38, central domain", "go_ids": ["GO:0006013", "GO:0004559"], "go_terms": ["GO:0006013:mannose metabolic process:P", "GO:0004559:alpha-mannosidase activity:F"], "name": "Glyco_hydro_38_cen", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-MMU-8853383", "R-RNO-8853383", "R-BTA-8853383", "R-HSA-6811438", "R-DME-975578", "R-HSA-975578", "R-HSA-8853383", "R-HSA-9694548", "R-SPO-8853383", "R-MMU-6798695", "R-RNO-975578", "R-BTA-6798695", "R-MMU-975578", "R-DDI-8853383", "R-SCE-8853383"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-BTA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-9694548:r:Maturation of spike protein", "R-SPO-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DDI-8853383:r:Lysosomal oligosaccharide catabolism", "R-SCE-8853383:r:Lysosomal oligosaccharide catabolism"], "type": "Domain"}, "IPR015342": {"description": "Peroxisomal ATPase PEX1, N-terminal C-lobe", "go_ids": ["GO:0005524", "GO:0005777", "GO:0007031"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0005777:peroxisome:C", "GO:0007031:peroxisome organization:P"], "name": "PEX1-N_C-lobe", "pathway_ids": ["PWY-7250", "R-HSA-9033241", "R-MMU-9033241"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR015343": {"description": "Peroxisomal ATPase PEX1, N-terminal N-lobe", "go_ids": [], "go_terms": [], "name": "PEX1-N-lobe", "pathway_ids": ["PWY-7250", "R-HSA-9033241", "R-MMU-9033241"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR015344": {"description": "Vibrio cholerae neuraminidase, lectin-like domain", "go_ids": ["GO:0033691"], "go_terms": ["GO:0033691:sialic acid binding:F"], "name": "VCNA_lectin-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015345": {"description": "Cytokinin dehydrogenase 1, FAD/cytokinin binding domain", "go_ids": ["GO:0009690", "GO:0019139", "GO:0050660"], "go_terms": ["GO:0009690:cytokinin metabolic process:P", "GO:0019139:cytokinin dehydrogenase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "Cytokinin_DH_FAD/cytokin-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015346": {"description": "DNA topoisomerase I, N-terminal, viral", "go_ids": ["GO:0003677", "GO:0003916", "GO:0006265"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003916:DNA topoisomerase activity:F", "GO:0006265:DNA topological change:P"], "name": "TopoI_N_vir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015347": {"description": "STAT transcription factor homologue, coiled coil", "go_ids": [], "go_terms": [], "name": "STAT_TF_homologue_CC", "pathway_ids": ["R-DDI-9008059", "R-DDI-9020591", "R-DDI-909733", "R-DDI-8984722", "R-DDI-3249367", "R-DDI-9020933", "R-DDI-8854691", "R-DDI-8985947", "R-DDI-877300", "R-DDI-9020956", "R-DDI-9860927", "R-DDI-1169408", "R-DDI-9833482", "R-DDI-6785807", "R-DDI-201556", "R-DDI-6783783", "R-DDI-1059683", "R-DDI-9701898", "R-DDI-8983432", "R-DDI-877312"], "pathways": ["R-DDI-9008059:r:Interleukin-37 signaling", "R-DDI-9020591:r:Interleukin-12 signaling", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-DDI-8984722:r:Interleukin-35 Signalling", "R-DDI-3249367:r:STAT6-mediated induction of chemokines", "R-DDI-9020933:r:Interleukin-23 signaling", "R-DDI-8854691:r:Interleukin-20 family signaling", "R-DDI-8985947:r:Interleukin-9 signaling", "R-DDI-877300:r:Interferon gamma signaling", "R-DDI-9020956:r:Interleukin-27 signaling", "R-DDI-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-9833482:r:PKR-mediated signaling", "R-DDI-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DDI-201556:r:Signaling by ALK", "R-DDI-6783783:r:Interleukin-10 signaling", "R-DDI-1059683:r:Interleukin-6 signaling", "R-DDI-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DDI-8983432:r:Interleukin-15 signaling", "R-DDI-877312:r:Regulation of IFNG signaling"], "type": "Domain"}, "IPR015348": {"description": "Clathrin, heavy chain, linker, core motif", "go_ids": ["GO:0005198", "GO:0006886", "GO:0016192", "GO:0030130", "GO:0030132"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P", "GO:0030130:clathrin coat of trans-Golgi network vesicle:C", "GO:0030132:clathrin coat of coated pit:C"], "name": "Clathrin_H-chain_linker_core", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-SPO-437239", "R-SCE-8856828", "R-DME-190873", "R-BTA-196025", "R-BTA-9013424", "R-HSA-9700645", "R-HSA-8856828", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-9013424", "R-CEL-432722", "R-HSA-9013424", "R-RNO-8964038", "R-BTA-190873", "R-DME-5099900", "R-MMU-9013420", "R-RNO-9013424", "R-RNO-196025", "R-RNO-177504", "R-DDI-8856828", "R-SCE-9013420", "R-DME-3928665", "R-DME-8964038", "R-DDI-8964038", "R-DME-177504", "R-HSA-5140745", "R-RNO-8866427", "R-RNO-432722", "R-MMU-196025", "R-BTA-5099900", "R-RNO-432720", "R-DME-437239", "R-HSA-432720", "R-DME-196025", "R-DME-5140745", "R-HSA-437239", "R-CEL-8866427", "R-BTA-177504", "R-MMU-5140745", "R-SPO-8866427", "R-CEL-8964038", "R-SPO-190873", "R-MMU-8866427", "R-SPO-9013424", "R-SCE-196025", "R-SPO-196025", "R-RNO-9013420", "R-CEL-8856825", "R-SCE-8866427", "R-HSA-2132295", "R-DME-432720", "R-MMU-8856825", "R-HSA-190873", "R-CEL-432720", "R-MMU-432722", "R-CEL-190873", "R-DDI-437239", "R-CEL-437239", "R-DME-8866427", "R-DME-9013424", "R-SPO-8964038", "R-HSA-9725370", "R-MMU-190873", "R-CEL-5140745", "R-SCE-432720", "R-DDI-8866427", "R-RNO-190873", "R-MMU-8964038", "R-HSA-168275", "R-MMU-2132295", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-DME-8856828", "R-SPO-9013420", "R-SCE-9013424", "R-RNO-5099900", "R-SCE-8964038", "R-HSA-432722", "R-SPO-432720", "R-BTA-2132295", "R-MMU-432720", "R-BTA-8856828", "R-HSA-196025", "R-CEL-8856828", "R-BTA-9013420", "R-RNO-2132295", "R-DME-8856825", "R-HSA-9013420", "R-RNO-8856825", "R-MMU-437239", "R-RNO-437239", "R-BTA-432720", "R-CEL-196025", "R-DDI-432720", "R-HSA-5099900", "R-DME-432722", "R-MMU-9013424", "R-SPO-8856828", "R-CEL-3928665", "R-HSA-177504", "R-HSA-8866427", "R-BTA-8856825", "R-BTA-8964038", "R-HSA-8856825", "R-HSA-3928665", "R-SCE-437239", "R-MMU-177504", "R-CEL-9013420", "R-BTA-432722", "R-BTA-5140745", "R-SCE-190873", "R-HSA-8964038", "R-DME-9013420"], "pathways": ["R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-437239:r:Recycling pathway of L1", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-DME-190873:r:Gap junction degradation", "R-BTA-196025:r:Formation of annular gap junctions", "R-BTA-9013424:r:RHOV GTPase cycle", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-9013424:r:RHOV GTPase cycle", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-8964038:r:LDL clearance", "R-BTA-190873:r:Gap junction degradation", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-RNO-196025:r:Formation of annular gap junctions", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-SCE-9013420:r:RHOU GTPase cycle", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-8964038:r:LDL clearance", "R-DDI-8964038:r:LDL clearance", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-196025:r:Formation of annular gap junctions", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-196025:r:Formation of annular gap junctions", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-437239:r:Recycling pathway of L1", "R-CEL-8866427:r:VLDLR internalisation and degradation", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-CEL-8964038:r:LDL clearance", "R-SPO-190873:r:Gap junction degradation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SCE-196025:r:Formation of annular gap junctions", "R-SPO-196025:r:Formation of annular gap junctions", "R-RNO-9013420:r:RHOU GTPase cycle", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-190873:r:Gap junction degradation", "R-DDI-437239:r:Recycling pathway of L1", "R-CEL-437239:r:Recycling pathway of L1", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-DME-9013424:r:RHOV GTPase cycle", "R-SPO-8964038:r:LDL clearance", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-190873:r:Gap junction degradation", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-RNO-190873:r:Gap junction degradation", "R-MMU-8964038:r:LDL clearance", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-437239:r:Recycling pathway of L1", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-SPO-9013420:r:RHOU GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SCE-8964038:r:LDL clearance", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-196025:r:Formation of annular gap junctions", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-CEL-196025:r:Formation of annular gap junctions", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-190873:r:Gap junction degradation", "R-HSA-8964038:r:LDL clearance", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR015349": {"description": "GTP-binding protein OBG, C-terminal", "go_ids": ["GO:0000166"], "go_terms": ["GO:0000166:nucleotide binding:F"], "name": "OCT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015350": {"description": "Beta-trefoil DNA-binding domain", "go_ids": ["GO:0000978", "GO:0006357"], "go_terms": ["GO:0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "Beta-trefoil_DNA-bd_dom", "pathway_ids": ["R-HSA-9013508", "R-DME-350054", "R-HSA-8941856", "R-HSA-210744", "R-MMU-2122947", "R-HSA-2894862", "R-HSA-9824272", "R-BTA-8941856", "R-HSA-350054", "R-BTA-350054", "R-HSA-1912408", "R-HSA-9013695", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-2122947"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-DME-350054:r:Notch-HLH transcription pathway", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9824272:r:Somitogenesis", "R-BTA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Domain"}, "IPR015351": {"description": "RBP-J/Cbf11/Cbf12, DNA binding", "go_ids": ["GO:0003677", "GO:0003700", "GO:0005634", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RBP-J/Cbf11/Cbf12_DNA-bd", "pathway_ids": ["R-HSA-9013508", "R-DME-350054", "R-HSA-8941856", "R-HSA-210744", "R-MMU-2122947", "R-HSA-2894862", "R-HSA-9824272", "R-BTA-8941856", "R-HSA-350054", "R-BTA-350054", "R-HSA-1912408", "R-HSA-9013695", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-2122947"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-DME-350054:r:Notch-HLH transcription pathway", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9824272:r:Somitogenesis", "R-BTA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Domain"}, "IPR015352": {"description": "Hepsin, SRCR domain", "go_ids": ["GO:0004252", "GO:0070008"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0070008:serine-type exopeptidase activity:F"], "name": "Hepsin-SRCR_dom", "pathway_ids": ["R-RNO-8852405", "R-HSA-8852405", "R-MMU-8852405", "R-MMU-6806942", "R-HSA-6806942", "R-RNO-6806942"], "pathways": ["R-RNO-8852405:r:Signaling by MST1", "R-HSA-8852405:r:Signaling by MST1", "R-MMU-8852405:r:Signaling by MST1", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-6806942:r:MET Receptor Activation"], "type": "Domain"}, "IPR015353": {"description": "Rubisco LSMT, substrate-binding domain", "go_ids": [], "go_terms": [], "name": "Rubisco_LSMT_subst-bd", "pathway_ids": ["R-DRE-3214841", "R-MMU-3214841", "R-HSA-3214841", "R-RNO-3214841"], "pathways": ["R-DRE-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-RNO-3214841:r:PKMTs methylate histone lysines"], "type": "Domain"}, "IPR015354": {"description": "DNA partition complex, ParG", "go_ids": [], "go_terms": [], "name": "DNA_partition_ParG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015355": {"description": "Pertussis toxin, subunit S4", "go_ids": [], "go_terms": [], "name": "Pertussis_toxin_subS4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015356": {"description": "Pertussis toxin, subunit S5", "go_ids": [], "go_terms": [], "name": "Pertussis_toxin_subS5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015357": {"description": "EryA2-like, docking domain", "go_ids": [], "go_terms": [], "name": "EryA2_docking", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015358": {"description": "Transcription regulator MerR, DNA binding", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_MerR_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015359": {"description": "Phosphoinositide-specific phospholipase C, EF-hand-like domain", "go_ids": [], "go_terms": [], "name": "PLC_EF-hand-like", "pathway_ids": ["PWY-6367", "PWY-7039", "PWY-6351", "PWY-8052", "R-CEL-1855204", "R-BTA-1855204", "R-SCE-1855204", "R-SCE-202433", "R-CEL-112043", "R-SCE-5607764", "R-SCE-114604", "R-HSA-1855204", "R-RNO-1855204", "R-SSC-1855204", "R-GGA-1855204", "R-MMU-1855204", "R-CEL-416476"], "pathways": ["PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-202433:r:Generation of second messenger molecules", "R-CEL-112043:r:PLC beta mediated events", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-SCE-114604:r:GPVI-mediated activation cascade", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SSC-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-GGA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-416476:r:G alpha (q) signalling events"], "type": "Domain"}, "IPR015360": {"description": "XPC-binding domain", "go_ids": ["GO:0003684", "GO:0006289", "GO:0043161"], "go_terms": ["GO:0003684:damaged DNA binding:F", "GO:0006289:nucleotide-excision repair:P", "GO:0043161:proteasome-mediated ubiquitin-dependent protein catabolic process:P"], "name": "XPC-bd", "pathway_ids": ["R-HSA-532668", "R-DDI-5696395", "R-BTA-5696394", "R-RNO-5696395", "R-BTA-5689877", "R-SPO-5696394", "R-RNO-5696394", "R-SPO-5696395", "R-MMU-5696395", "R-MMU-5689877", "R-RNO-5689877", "R-DDI-5696394", "R-RNO-532668", "R-HSA-5696395", "R-HSA-5696394", "R-MMU-5696394", "R-MMU-532668", "R-BTA-5696395", "R-BTA-532668", "R-HSA-5689877"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5689877:r:Josephin domain DUBs", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5689877:r:Josephin domain DUBs", "R-RNO-5689877:r:Josephin domain DUBs", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689877:r:Josephin domain DUBs"], "type": "Domain"}, "IPR015361": {"description": "Taq polymerase, thermostable, exonuclease region", "go_ids": ["GO:0001882", "GO:0003887", "GO:0006260", "GO:0006281"], "go_terms": ["GO:0001882:nucleoside binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006260:DNA replication:P", "GO:0006281:DNA repair:P"], "name": "Taq_pol_thermo_exonuc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015362": {"description": "WIBG, Mago-binding", "go_ids": [], "go_terms": [], "name": "WIBG_mago-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015364": {"description": "Rhamnogalacturonase B, N-terminal", "go_ids": ["GO:0005975", "GO:0016837", "GO:0030246"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016837:carbon-oxygen lyase activity, acting on polysaccharides:F", "GO:0030246:carbohydrate binding:F"], "name": "RhgB_N", "pathway_ids": ["PWY-6771"], "pathways": ["PWY-6771:t:rhamnogalacturonan type I degradation II (bacteria)"], "type": "Domain"}, "IPR015365": {"description": "Elongation factor P, C-terminal", "go_ids": ["GO:0043043", "GO:0005737"], "go_terms": ["GO:0043043:peptide biosynthetic process:P", "GO:0005737:cytoplasm:C"], "name": "Elong-fact-P_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015366": {"description": "Peptidase S53, activation domain", "go_ids": ["GO:0008236"], "go_terms": ["GO:0008236:serine-type peptidase activity:F"], "name": "S53_propep", "pathway_ids": ["R-HSA-381038"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes"], "type": "Domain"}, "IPR015367": {"description": "Transcription factor CEP-1, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "Trans_fact_CEP1_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015368": {"description": "Ubiquitin-conjugating enzyme, C-terminal fungi", "go_ids": [], "go_terms": [], "name": "UBA_C_fun", "pathway_ids": ["R-SPO-983168", "R-SCE-983168"], "pathways": ["R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR015369": {"description": "Follistatin/Osteonectin EGF domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Follistatin/Osteonectin_EGF", "pathway_ids": ["R-CEL-1592389", "R-SSC-2473224", "R-HSA-3000497", "R-RNO-3000497", "R-HSA-3000178", "R-HSA-1251985", "R-SSC-114608", "R-BTA-201451", "R-HSA-201451", "R-CEL-114608", "R-MMU-3000497", "R-BTA-2473224", "R-HSA-2473224", "R-MMU-8957275", "R-RNO-114608", "R-BTA-3000497", "R-RNO-381426", "R-BTA-8957275", "R-HSA-114608", "R-BTA-114608", "R-RNO-2473224", "R-DRE-2473224", "R-RNO-8957275", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-BTA-381426", "R-MMU-201451", "R-HSA-8957275", "R-SSC-3000497", "R-RNO-201451", "R-MMU-2473224", "R-HSA-381426", "R-MMU-114608"], "pathways": ["R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-SSC-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-114608:r:Platelet degranulation", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-CEL-114608:r:Platelet degranulation", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-BTA-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-BTA-3000497:r:Scavenging by Class H Receptors", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-RNO-2473224:r:Antagonism of Activin by Follistatin", "R-DRE-2473224:r:Antagonism of Activin by Follistatin", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-201451:r:Signaling by BMP", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-3000497:r:Scavenging by Class H Receptors", "R-RNO-201451:r:Signaling by BMP", "R-MMU-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR015370": {"description": "T-cell receptor alpha chain, constant domain", "go_ids": [], "go_terms": [], "name": "TCR_alpha_C", "pathway_ids": ["R-MMU-389948", "R-HSA-202427", "R-MMU-202433", "R-MMU-198933", "R-MMU-202424", "R-HSA-202424", "R-HSA-202433", "R-HSA-198933", "R-MMU-202427", "R-HSA-202430", "R-HSA-389948", "R-MMU-202430"], "pathways": ["R-MMU-389948:r:Co-inhibition by PD-1", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-389948:r:Co-inhibition by PD-1", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse"], "type": "Domain"}, "IPR015371": {"description": "Endonuclease VIII-like 1, DNA binding", "go_ids": [], "go_terms": [], "name": "Endonuclease-VIII_DNA-bd", "pathway_ids": ["R-HSA-110328", "R-HSA-110329", "R-MMU-5649702", "R-HSA-5649702", "R-MMU-110328", "R-HSA-9616334", "R-MMU-110329"], "pathways": ["R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9616334:r:Defective Base Excision Repair Associated with NEIL1", "R-MMU-110329:r:Cleavage of the damaged pyrimidine"], "type": "Domain"}, "IPR015373": {"description": "Interferon/interleukin receptor domain", "go_ids": [], "go_terms": [], "name": "Interferon/interleukin_rcp_dom", "pathway_ids": ["R-HSA-9833109", "R-MMU-8854691", "R-HSA-449836", "R-BTA-140834", "R-HSA-9705671", "R-MMU-5673001", "R-MMU-140834", "R-HSA-9679191", "R-HSA-9732724", "R-RNO-8854691", "R-HSA-8854691", "R-BTA-912694", "R-MMU-912526", "R-MMU-6783783", "R-HSA-909733", "R-HSA-877312", "R-BTA-909733", "R-RNO-140834", "R-HSA-877300", "R-MMU-512988", "R-HSA-912694", "R-HSA-140834", "R-MMU-909733", "R-HSA-9031628", "R-HSA-6783783", "R-GGA-449836", "R-MMU-912694", "R-GGA-8854691"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-449836:r:Other interleukin signaling", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-BTA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-6783783:r:Interleukin-10 signaling", "R-GGA-449836:r:Other interleukin signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-GGA-8854691:r:Interleukin-20 family signaling"], "type": "Domain"}, "IPR015374": {"description": "Chs5p-Arf1p binding", "go_ids": [], "go_terms": [], "name": "ChAPs", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015375": {"description": "NADH pyrophosphatase-like, N-terminal", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "NADH_PPase-like_N", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-5381", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "PWY-7761", "R-MMU-196807", "R-HSA-196807", "R-SPO-196807", "R-BTA-196807", "R-HSA-499943", "R-MMU-499943"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-5381:t:NAD salvage (plants)", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "PWY-7761:t:NAD salvage pathway II (PNC IV cycle)", "R-MMU-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-SPO-196807:r:Nicotinate metabolism", "R-BTA-196807:r:Nicotinate metabolism", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Domain"}, "IPR015376": {"description": "Zinc ribbon, NADH pyrophosphatase", "go_ids": ["GO:0016787", "GO:0046872"], "go_terms": ["GO:0016787:hydrolase activity:F", "GO:0046872:metal ion binding:F"], "name": "Znr_NADH_PPase", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-5381", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "PWY-7761", "R-MMU-196807", "R-HSA-196807", "R-BTA-196807", "R-HSA-499943", "R-MMU-499943", "R-SCE-196807"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-5381:t:NAD salvage (plants)", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "PWY-7761:t:NAD salvage pathway II (PNC IV cycle)", "R-MMU-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-BTA-196807:r:Nicotinate metabolism", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SCE-196807:r:Nicotinate metabolism"], "type": "Domain"}, "IPR015377": {"description": "Fumarylacetoacetase, N-terminal", "go_ids": ["GO:0004334", "GO:0009072"], "go_terms": ["GO:0004334:fumarylacetoacetase activity:F", "GO:0009072:aromatic amino acid metabolic process:P"], "name": "Fumarylacetoacetase_N", "pathway_ids": ["R-HSA-8963684", "R-RNO-8963684", "R-CEL-8963684", "R-DDI-8963684", "R-MMU-8963684"], "pathways": ["R-HSA-8963684:r:Tyrosine catabolism", "R-RNO-8963684:r:Tyrosine catabolism", "R-CEL-8963684:r:Tyrosine catabolism", "R-DDI-8963684:r:Tyrosine catabolism", "R-MMU-8963684:r:Tyrosine catabolism"], "type": "Domain"}, "IPR015378": {"description": "Transposase-like, Mu, C-terminal", "go_ids": [], "go_terms": [], "name": "Transposase-like_Mu_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015379": {"description": "Minor capsid protein P30, tectiviridae", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "VP30", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015381": {"description": "XLF-like, N-terminal", "go_ids": ["GO:0005634", "GO:0006302"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006302:double-strand break repair:P"], "name": "XLF-like_N", "pathway_ids": ["R-RNO-5693571", "R-MMU-5693571", "R-DRE-5693571", "R-HSA-5693571"], "pathways": ["R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Domain"}, "IPR015382": {"description": "KCNMB2, ball/chain domain", "go_ids": [], "go_terms": [], "name": "KCNMB2_ball_chain_dom", "pathway_ids": ["R-HSA-418457", "R-RNO-1296052", "R-HSA-1296052", "R-MMU-1296052"], "pathways": ["R-HSA-418457:r:cGMP effects", "R-RNO-1296052:r:Ca2+ activated K+ channels", "R-HSA-1296052:r:Ca2+ activated K+ channels", "R-MMU-1296052:r:Ca2+ activated K+ channels"], "type": "Domain"}, "IPR015383": {"description": "Cortexillin, coiled coil", "go_ids": [], "go_terms": [], "name": "Cortexillin-I_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015384": {"description": "TACI, cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "TACI_Cys-rich-dom", "pathway_ids": ["R-HSA-5669034", "R-MMU-5669034"], "pathways": ["R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Domain"}, "IPR015385": {"description": "Bacteriophage P22, Gp8, scaffold", "go_ids": [], "go_terms": [], "name": "Phage_P22_Gp8_scaffold", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015386": {"description": "MHC class II-associated invariant chain/CLIP, MHC II-interacting", "go_ids": ["GO:0006886", "GO:0006955", "GO:0016020", "GO:0019882", "GO:0042289"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0006955:immune response:P", "GO:0016020:membrane:C", "GO:0019882:antigen processing and presentation:P", "GO:0042289:MHC class II protein binding:F"], "name": "MHC_II-assoc_invar/CLIP_MHC-bd", "pathway_ids": ["R-HSA-9925563", "R-RNO-2132295", "R-HSA-2132295", "R-RNO-202733", "R-MMU-202733", "R-MMU-2132295", "R-HSA-202733"], "pathways": ["R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR015387": {"description": "LuxQ, periplasmic domain", "go_ids": ["GO:0016791", "GO:0004673"], "go_terms": ["GO:0016791:phosphatase activity:F", "GO:0004673:protein histidine kinase activity:F"], "name": "LuxQ-periplasm_dom", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Domain"}, "IPR015388": {"description": "FCP1-like phosphatase, C-terminal", "go_ids": [], "go_terms": [], "name": "FCP1_C", "pathway_ids": ["R-MMU-6796648", "R-HSA-167238", "R-MMU-113418", "R-HSA-167243", "R-HSA-167242", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-HSA-167290", "R-HSA-167200", "R-HSA-75955", "R-HSA-167152", "R-HSA-113418", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR015389": {"description": "POU, class 2, associating factor 1", "go_ids": [], "go_terms": [], "name": "PD-C2-AF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015390": {"description": "Rabaptin, GTPase-Rab5 binding domain", "go_ids": [], "go_terms": [], "name": "Rabaptin_Rab5-bd_dom", "pathway_ids": ["R-HSA-8854214"], "pathways": ["R-HSA-8854214:r:TBC/RABGAPs"], "type": "Domain"}, "IPR015391": {"description": "SurA N-terminal", "go_ids": [], "go_terms": [], "name": "SurA_N", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR015392": {"description": "TehB/YeaR-like domain", "go_ids": [], "go_terms": [], "name": "TehB/YeaR-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015393": {"description": "Domain of unknown function DUF1972", "go_ids": [], "go_terms": [], "name": "DUF1972", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015395": {"description": "C-myb, C-terminal", "go_ids": [], "go_terms": [], "name": "C-myb_C", "pathway_ids": ["R-HSA-8869496", "R-HSA-1362300", "R-HSA-156711", "R-HSA-983231", "R-HSA-9616222", "R-HSA-9834899", "R-HSA-8939236", "R-HSA-9018519", "R-HSA-5601884"], "pathways": ["R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis"], "type": "Domain"}, "IPR015396": {"description": "Acyl-CoA dehydrogenase, C-terminal, bacterial-type", "go_ids": ["GO:0003995", "GO:0033539"], "go_terms": ["GO:0003995:acyl-CoA dehydrogenase activity:F", "GO:0033539:fatty acid beta-oxidation using acyl-CoA dehydrogenase:P"], "name": "FadE_C", "pathway_ids": ["PWY-7094", "PWY-7654", "PWY-8354", "PWY-8181"], "pathways": ["PWY-7094:t:fatty acid salvage", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-8354:t:adipate degradation", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation"], "type": "Domain"}, "IPR015397": {"description": "Glycosyl transferase 1, domain A", "go_ids": [], "go_terms": [], "name": "Glyco_trans_A_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015399": {"description": "Domain of unknown function DUF1977, DnaJ-like", "go_ids": [], "go_terms": [], "name": "DUF1977_DnaJ-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015400": {"description": "Domain of unknown function DUF1978, IncA", "go_ids": [], "go_terms": [], "name": "DUF1978_IncA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015401": {"description": "Transposase, MuDR, N-terminal", "go_ids": [], "go_terms": [], "name": "Transposase_MuDR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015402": {"description": "Protein of unknown function DUF1980", "go_ids": [], "go_terms": [], "name": "DUF1980", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015403": {"description": "Mon2/Sec7/BIG1-like, HDS", "go_ids": [], "go_terms": [], "name": "Mon2/Sec7/BIG1-like_HDS", "pathway_ids": ["R-HSA-390471"], "pathways": ["R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis"], "type": "Domain"}, "IPR015404": {"description": "Sorting nexin/Vps5-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Vps5_C", "pathway_ids": ["R-BTA-432722", "R-HSA-432722", "R-RNO-432722", "R-MMU-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR015405": {"description": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like", "go_ids": ["GO:0016651", "GO:0051536"], "go_terms": ["GO:0016651:oxidoreductase activity, acting on NAD(P)H:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "NDUFS1-like_C", "pathway_ids": ["PWY-4302", "PWY-6692", "PWY-3781", "PWY-5083", "R-RNO-611105", "R-HSA-611105", "R-MMU-9837999", "R-MMU-6799198", "R-BTA-9837999", "R-HSA-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DME-9837999", "R-MMU-611105", "R-HSA-9837999", "R-RNO-9837999", "R-BTA-6799198", "R-DME-611105", "R-BTA-611105"], "pathways": ["PWY-4302:t:aerobic respiration III (alternative oxidase pathway)", "PWY-6692:t:Fe(II) oxidation", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-5083:t:NAD(P)/NADPH interconversion", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6799198:r:Complex I biogenesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR015406": {"description": "Tip attachment protein J, central straight fiber domain", "go_ids": [], "go_terms": [], "name": "GpJ_CSF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015407": {"description": "Phytochelatin synthase, C-terminal", "go_ids": ["GO:0010038", "GO:0016756", "GO:0046872", "GO:0046938"], "go_terms": ["GO:0010038:response to metal ion:P", "GO:0016756:glutathione gamma-glutamylcysteinyltransferase activity:F", "GO:0046872:metal ion binding:F", "GO:0046938:phytochelatin biosynthetic process:P"], "name": "Phytochelatin_synthase_C", "pathway_ids": ["PWY-6745"], "pathways": ["PWY-6745:t:phytochelatins biosynthesis"], "type": "Domain"}, "IPR015408": {"description": "Zinc finger, Mcm10/DnaG-type", "go_ids": ["GO:0006260", "GO:0005634"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0005634:nucleus:C"], "name": "Znf_Mcm10/DnaG", "pathway_ids": ["R-DME-68962", "R-SPO-176187", "R-DRE-68962", "R-MMU-68962", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-HSA-176187", "R-SCE-176187", "R-SCE-68962", "R-DME-176187"], "pathways": ["R-DME-68962:r:Activation of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-DRE-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR015409": {"description": "D-lactate dehydrogenase, membrane binding, C-terminal", "go_ids": ["GO:0050660", "GO:0055085"], "go_terms": ["GO:0050660:flavin adenine dinucleotide binding:F", "GO:0055085:transmembrane transport:P"], "name": "Lactate_DH_C", "pathway_ids": ["PWY-5386", "PWY-7425"], "pathways": ["PWY-5386:t:methylglyoxal degradation I", "PWY-7425:t:2-chloroacrylate degradation I"], "type": "Domain"}, "IPR015410": {"description": "Domain of unknown function DUF1985", "go_ids": [], "go_terms": [], "name": "DUF1985", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015411": {"description": "Replication factor Mcm10, C-terminal", "go_ids": [], "go_terms": [], "name": "Rep_factor_Mcm10_C", "pathway_ids": ["R-DME-68962", "R-DME-176187", "R-DRE-68962", "R-HSA-176187", "R-MMU-68962", "R-MMU-176187", "R-HSA-68962"], "pathways": ["R-DME-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DRE-68962:r:Activation of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex"], "type": "Domain"}, "IPR015413": {"description": "Methionyl/Leucyl tRNA synthetase", "go_ids": ["GO:0000166", "GO:0004812", "GO:0005524", "GO:0006418"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004812:aminoacyl-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0006418:tRNA aminoacylation for protein translation:P"], "name": "Methionyl/Leucyl_tRNA_Synth", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-HSA-9856649", "R-DDI-9856649", "R-HSA-2408522", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR015414": {"description": "Transmembrane protein TMEM64", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TMEM64", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015415": {"description": "Spastin/Vps4, C-terminal", "go_ids": [], "go_terms": [], "name": "Spast_Vps4_C", "pathway_ids": ["R-RNO-917729", "R-DRE-5689877", "R-DRE-382556", "R-MMU-917729", "R-DME-382556", "R-MMU-9668328", "R-CEL-6798695", "R-DME-8951664", "R-DRE-8951664", "R-CEL-532668", "R-CEL-5689877", "R-CEL-5358346", "R-DRE-532668", "R-DME-5689896", "R-HSA-9668328", "R-CEL-9013407", "R-SPO-9668328", "R-CEL-110320", "R-SCE-9668328", "R-CEL-382556", "R-DRE-6798695", "R-HSA-912446", "R-DRE-9013407", "R-BTA-9668328", "R-DRE-5689896", "R-XTR-9668328", "R-MMU-5693568", "R-DRE-9668328", "R-DDI-917729", "R-HSA-5693568", "R-SSC-9668328", "R-DME-9013407", "R-HSA-9610379", "R-DRE-5358346", "R-DRE-9931269", "R-DRE-3371511", "R-RNO-9668328", "R-CEL-9755511", "R-DME-6798695", "R-DME-110320", "R-DME-9668328", "R-GGA-9668328", "R-CEL-9931269", "R-DME-3371511", "R-HSA-162588", "R-DME-532668", "R-MMU-912446", "R-DME-9755511", "R-HSA-917729", "R-DRE-9755511", "R-DRE-110320", "R-DRE-8876725", "R-RNO-5693568", "R-BTA-917729", "R-DME-5358346", "R-CEL-8951664", "R-DDI-9668328", "R-RNO-912446"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DRE-5689877:r:Josephin domain DUBs", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-382556:r:ABC-family proteins mediated transport", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-5689877:r:Josephin domain DUBs", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-SCE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-912446:r:Meiotic recombination", "R-DRE-9013407:r:RHOH GTPase cycle", "R-BTA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-XTR-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SSC-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-9013407:r:RHOH GTPase cycle", "R-HSA-9610379:r:HCMV Late Events", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-DRE-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DRE-3371511:r:HSF1 activation", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-110320:r:Translesion Synthesis by POLH", "R-DME-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-GGA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DME-3371511:r:HSF1 activation", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-912446:r:Meiotic recombination", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-DRE-8876725:r:Protein methylation", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-912446:r:Meiotic recombination"], "type": "Domain"}, "IPR015416": {"description": "Zinc finger, H2C2-type, histone UAS binding", "go_ids": [], "go_terms": [], "name": "Znf_H2C2_histone_UAS-bd", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR015417": {"description": "Glycine/sarcosine/betaine reductase complex, protein B, subunit alpha/ beta", "go_ids": ["GO:0050485"], "go_terms": ["GO:0050485:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor:F"], "name": "Gly_reductase_pB_sua/b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015418": {"description": "Chromatin modification-related protein Eaf6", "go_ids": ["GO:0000123"], "go_terms": ["GO:0000123:histone acetyltransferase complex:C"], "name": "Eaf6", "pathway_ids": ["R-MMU-3214847", "R-HSA-6804758", "R-DRE-6804758", "R-SPO-6804758", "R-MMU-6804758", "R-DME-6804758", "R-HSA-3214847", "R-DRE-3214847", "R-GGA-6804758"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-3214847:r:HATs acetylate histones", "R-DRE-3214847:r:HATs acetylate histones", "R-GGA-6804758:r:Regulation of TP53 Activity through Acetylation"], "type": "Family"}, "IPR015419": {"description": "CTAG/Pcc1 family", "go_ids": [], "go_terms": [], "name": "CTAG/Pcc1", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR015420": {"description": "Peptidase S1A, nudel", "go_ids": [], "go_terms": [], "name": "Peptidase_S1A_nudel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015421": {"description": "Pyridoxal phosphate-dependent transferase, major domain", "go_ids": [], "go_terms": [], "name": "PyrdxlP-dep_Trfase_major", "pathway_ids": ["R-HSA-71240", "R-HSA-1362409", "R-DDI-8964539", "R-GGA-8963693", "R-SCE-916853", "R-CEL-71064", "R-MMU-916853", "R-MMU-9013408", "R-HSA-209905", "R-DDI-71064", "R-SPO-1442490", "R-DME-947581", "R-RNO-9033241", "R-MMU-2408508", 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"R-MMU-1660661:r:Sphingolipid de novo biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-8963684:r:Tyrosine catabolism", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9856872:r:Malate-aspartate shuttle", "R-XTR-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-BTA-70921:r:Histidine catabolism", "R-RNO-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-HSA-888568:r:GABA synthesis", "R-CFA-888568:r:GABA synthesis", "R-SPO-189451:r:Heme biosynthesis", "R-SCE-8964208:r:Phenylalanine metabolism", "R-HSA-1237112:r:Methionine salvage pathway", "R-SPO-947581:r:Molybdenum cofactor biosynthesis", "R-CEL-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-70268:r:Pyruvate metabolism", "R-HSA-1483213:r:Synthesis of PE", "R-RNO-8963684:r:Tyrosine catabolism", "R-MMU-196757:r:Metabolism of folate and pterines", "R-SPO-71262:r:Carnitine synthesis", "R-XTR-8963693:r:Aspartate and asparagine metabolism", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-977347:r:Serine metabolism", "R-SCE-1614558:r:Degradation of cysteine and homocysteine", "R-DME-71064:r:Lysine catabolism", "R-BTA-8963693:r:Aspartate and asparagine metabolism", "R-HSA-9013408:r:RHOG GTPase cycle", "R-PFA-8964539:r:Glutamate and glutamine metabolism", "R-BTA-9856872:r:Malate-aspartate shuttle", "R-HSA-70921:r:Histidine catabolism", "R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-SCE-389661:r:Glyoxylate metabolism and glycine degradation", "R-DME-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DDI-1614603:r:Cysteine formation from homocysteine", "R-BTA-8964539:r:Glutamate and glutamine metabolism"], "type": "Homologous_superfamily"}, "IPR015425": {"description": "Formin, FH2 domain", "go_ids": [], "go_terms": [], "name": "FH2_Formin", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-MMU-6785631", "R-HSA-6798695", "R-HSA-9013409", "R-RNO-6785631", "R-CEL-8980692", "R-MMU-9013106", "R-CEL-5663220", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-BTA-5663220", "R-HSA-9013106", "R-MMU-9013404", "R-HSA-9013423", "R-DME-9035034", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013406", "R-RNO-9013404", "R-RNO-9013406", "R-RNO-9013106", "R-RNO-9013408", "R-DME-5663220", "R-DME-9013423", "R-DRE-5663220", "R-HSA-9013408", "R-MMU-5663220", "R-MMU-9035034", "R-DME-9013149", "R-DRE-9013106", "R-DME-8980692", "R-DME-6798695", "R-DME-6785631", "R-MMU-4086400", "R-HSA-4086400", "R-HSA-6785631", "R-RNO-5663220", "R-RNO-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-HSA-8980692", "R-HSA-9854909", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9013026", "R-MMU-6798695", "R-HSA-5663220", "R-DRE-8980692", "R-HSA-9013406", "R-MMU-9013149", "R-BTA-9013106", "R-RNO-6798695"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-9013106:r:RHOC GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-4086400:r:PCP/CE pathway", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR015426": {"description": "Acetaldehyde dehydrogenase, C-terminal", "go_ids": ["GO:0008774", "GO:0009056"], "go_terms": ["GO:0008774:acetaldehyde dehydrogenase (acetylating) activity:F", "GO:0009056:catabolic process:P"], "name": "Acetylaldehyde_DH_C", "pathway_ids": ["PWY-5436", "PWY-7085", "PWY-5162", "PWY-5480", "PWY-6587", "PWY-7180", "PWY-8062", "PWY-8060"], "pathways": ["PWY-5436:t:L-threonine degradation IV", "PWY-7085:t:triethylamine degradation", "PWY-5162:t:2-hydroxypenta-2,4-dienoate degradation", "PWY-5480:t:pyruvate fermentation to ethanol I", "PWY-6587:t:pyruvate fermentation to ethanol III", "PWY-7180:t:2-deoxy-alpha-D-ribose 1-phosphate degradation", "PWY-8062:t:sulfoacetaldehyde degradation IV", "PWY-8060:t:2-deoxy-D-ribose degradation I"], "type": "Domain"}, "IPR015433": {"description": "Phosphatidylinositol 3-/4-kinase", "go_ids": ["GO:0046854"], "go_terms": ["GO:0046854:phosphatidylinositol phosphate biosynthetic process:P"], "name": "PI3/4_kinase", "pathway_ids": ["R-HSA-9842640", "R-MMU-1250342", "R-HSA-9607240", "R-DDI-114604", "R-MMU-8856828", "R-BTA-198203", "R-MMU-6811558", "R-MMU-114604", "R-CEL-1660514", "R-MMU-5654720", "R-HSA-912631", "R-BTA-5673001", "R-RNO-9607240", "R-RNO-9009391", "R-BTA-8851907", "R-MMU-210993", "R-MMU-9009391", "R-MMU-1632852", "R-RNO-512988", "R-BTA-1963642", "R-BTA-5654710", "R-RNO-912631", "R-HSA-5654695", "R-MMU-201556", "R-CEL-5654695", "R-RNO-1632852", "R-BTA-4420097", "R-RNO-6811558", "R-HSA-8853659", "R-CEL-1257604", "R-BTA-6811558", "R-SCE-1660517", "R-RNO-1963642", "R-HSA-9603381", "R-SPO-5668599", "R-HSA-512988", "R-RNO-416476", "R-MMU-5673001", "R-MMU-186763", "R-HSA-114604", "R-HSA-168138", "R-RNO-210993", "R-HSA-983695", "R-HSA-5654689", "R-HSA-2424491", "R-HSA-5637810", "R-DDI-392451", "R-SCE-1632852", "R-MMU-912526", "R-CEL-1433557", "R-RNO-2730905", "R-MMU-1963642", "R-HSA-389357", "R-CEL-1660517", "R-MMU-2730905", "R-DDI-1660514", "R-CEL-6811558", "R-SPO-1483248", "R-BTA-5654689", "R-BTA-2424491", "R-HSA-9680350", "R-RNO-8851907", "R-HSA-1839117", "R-CEL-1660516", "R-SCE-1660516", "R-BTA-1660499", "R-HSA-5655253", "R-HSA-9705671", "R-RNO-9842663", "R-RNO-1257604", "R-HSA-2029485", "R-CEL-5654720", "R-HSA-9665348", "R-MMU-1483248", "R-RNO-168138", "R-BTA-5654695", "R-BTA-9927354", "R-HSA-8851907", "R-BTA-912526", "R-HSA-9028335", "R-HSA-1963642", "R-MMU-512988", "R-HSA-2730905", "R-DDI-5668599", "R-HSA-112399", "R-HSA-9027276", "R-BTA-1433557", "R-BTA-512988", "R-MMU-202424", "R-CEL-8856828", "R-HSA-5655291", "R-MMU-912631", "R-BTA-180292", "R-MMU-109704", "R-HSA-5655332", "R-DDI-1632852", "R-RNO-1250342", "R-HSA-109704", "R-SPO-1660514", "R-MMU-1257604", "R-HSA-9842663", "R-BTA-9009391", "R-RNO-5654689", "R-MMU-1660499", "R-HSA-983170", "R-HSA-9009391", "R-XTR-1660514", "R-CEL-5654689", "R-RNO-5654695", "R-RNO-1660499", "R-BTA-109704", "R-HSA-912526", "R-BTA-9013404", "R-HSA-201556", "R-BTA-1257604", "R-MMU-8851907", "R-BTA-9027276", "R-BTA-210993", "R-SPO-1660517", "R-HSA-9856530", "R-BTA-9607240", "R-MMU-5654689", "R-MMU-9013149", "R-MMU-168138", "R-HSA-9725370", "R-CEL-9009391", "R-HSA-5668599", "R-CEL-114604", "R-BTA-389357", "R-CEL-1250342", "R-MMU-416476", "R-CEL-210993", "R-MMU-9607240", "R-HSA-180292", "R-MMU-1660516", "R-HSA-8856828", "R-RNO-5654710", "R-BTA-202424", "R-SCE-1660514", "R-CEL-912631", "R-CEL-432722", "R-RNO-9013149", "R-MMU-4420097", "R-HSA-9670439", "R-RNO-9027276", "R-MMU-9013404", "R-SPO-1660516", "R-CEL-5673001", "R-RNO-912526", "R-HSA-4420097", "R-RNO-112399", "R-RNO-198203", "R-MMU-389357", "R-RNO-2029485", "R-MMU-5654695", "R-MMU-392451", "R-BTA-8853659", "R-SCE-1483248", "R-RNO-202424", "R-MMU-5668599", "R-MMU-1660514", "R-BTA-112399", "R-RNO-9013404", "R-HSA-9673767", "R-MMU-2029485", "R-DDI-1660517", "R-HSA-9664565", "R-RNO-5673001", "R-HSA-5655302", "R-RNO-9927354", "R-RNO-389357", "R-RNO-201556", "R-HSA-9927354", "R-HSA-373753", "R-MMU-1433557", "R-HSA-1483248", "R-CEL-201556", "R-MMU-180292", "R-HSA-210993", "R-RNO-8853659", "R-CEL-180292", "R-MMU-8853659", "R-HSA-2219530", "R-BTA-912631", "R-HSA-1660516", "R-DRE-1660514", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-BTA-416476", "R-HSA-9013404", "R-HSA-9013149", "R-RNO-1660517", "R-HSA-9703648", "R-HSA-5654720", "R-HSA-1632852", "R-BTA-114604", "R-MMU-9027276", "R-CEL-186763", "R-HSA-1257604", "R-MMU-1660517", "R-HSA-198203", "R-MMU-5654710", "R-RNO-4420097", "R-SPO-1632852", "R-HSA-9679504", "R-HSA-1660517", "R-CEL-392451", "R-DDI-1660499", "R-MMU-432722", "R-BTA-5654720", "R-CEL-1632852", "R-RNO-109704", "R-CEL-5668599", "R-HSA-416476", "R-HSA-1250342", "R-RNO-1660514", "R-HSA-1660499", "R-CEL-416476", "R-CEL-9013149", "R-MMU-9842663", "R-RNO-5668599", "R-BTA-186763", "R-MMU-198203", "R-HSA-9673770", "R-BTA-201556", "R-RNO-1660516", "R-HSA-1236382", "R-HSA-9920951", "R-HSA-432722", "R-CEL-5654710", "R-BTA-2029485", "R-HSA-9694676", "R-DDI-1660516", "R-BTA-1250342", "R-MMU-983695", "R-RNO-180292", "R-HSA-1660514", "R-HSA-1433557", "R-MMU-112399", "R-HSA-186763", "R-RNO-114604", "R-HSA-9703465", "R-BTA-2730905", "R-RNO-2424491", "R-CEL-4420097", "R-RNO-1483248", "R-MMU-9927354", "R-CEL-1963642", "R-HSA-5654710", "R-RNO-5654720", "R-CEL-1660499", "R-MMU-2424491", "R-SCE-5668599", "R-HSA-202424", "R-RNO-186763", "R-HSA-392451"], "pathways": ["R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-BTA-198203:r:PI3K/AKT activation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-912631:r:Regulation of signaling by CBL", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-RNO-9607240:r:FLT3 Signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-210993:r:Tie2 Signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-1632852:r:Macroautophagy", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-912631:r:Regulation of signaling by CBL", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-201556:r:Signaling by ALK", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-RNO-1632852:r:Macroautophagy", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SCE-1632852:r:Macroautophagy", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-BTA-2424491:r:DAP12 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DDI-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-112399:r:IRS-mediated signalling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-912631:r:Regulation of signaling by CBL", "R-BTA-180292:r:GAB1 signalosome", "R-MMU-109704:r:PI3K Cascade", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DDI-1632852:r:Macroautophagy", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-109704:r:PI3K Cascade", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-XTR-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-109704:r:PI3K Cascade", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-201556:r:Signaling by ALK", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-210993:r:Tie2 Signaling", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9607240:r:FLT3 Signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-168138:r:Toll Like 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"R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-201556:r:Signaling by ALK", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-373753:r:Nephrin family interactions", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-201556:r:Signaling by ALK", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-8853659:r:RET signaling", "R-CEL-180292:r:GAB1 signalosome", "R-MMU-8853659:r:RET signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-BTA-912631:r:Regulation of signaling by CBL", 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"R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-BTA-201556:r:Signaling by ALK", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-112399:r:IRS-mediated signalling", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-2424491:r:DAP12 signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-2424491:r:DAP12 signaling", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma"], "type": "Family"}, "IPR015439": {"description": "Integrin beta-2 superfamily", "go_ids": [], "go_terms": [], "name": "Integrin_b-2_sf", "pathway_ids": ["R-HSA-6798695", 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"R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Family"}, "IPR015495": {"description": "Myb transcription factor, plants", "go_ids": [], "go_terms": [], "name": "Myb_TF_plants", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015496": {"description": "Ubiquilin", "go_ids": [], "go_terms": [], "name": "Ubiquilin", "pathway_ids": ["R-BTA-9909505", "R-HSA-9646399", "R-MMU-9909505", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9833482", "R-MMU-8856825", "R-HSA-977225", "R-HSA-936440", "R-HSA-1169408", "R-MMU-5205685", "R-HSA-9909505", "R-DDI-8856825", "R-MMU-9833482", "R-MMU-5689877", "R-BTA-936440", "R-RNO-5689877", "R-SPO-8856825", "R-BTA-5656169", "R-HSA-9833110", "R-HSA-5205685", "R-HSA-5656169", "R-HSA-5689877", "R-RNO-5205685", "R-HSA-168276", "R-RNO-8856825", "R-HSA-5675482", "R-MMU-5675482", "R-MMU-5656169", "R-HSA-983168", "R-MMU-1169408", "R-MMU-9646399", "R-HSA-909733", 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"R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1442490:r:Collagen degradation", "R-RNO-209952:r:Peptide hormone biosynthesis", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-DDI-159418:r:Recycling of bile acids and salts", "R-MMU-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-RNO-167060:r:NGF processing", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-CEL-186797:r:Signaling by PDGF", "R-MMU-1442490:r:Collagen degradation", "R-HSA-8964038:r:LDL clearance", "R-HSA-9953170:r:GBP-mediated host defense", "R-DME-186797:r:Signaling by PDGF"], "type": "Family"}, "IPR015505": {"description": "Coronin", "go_ids": [], "go_terms": [], "name": "Coronin", "pathway_ids": ["R-HSA-9636383"], "pathways": ["R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion"], "type": "Family"}, "IPR015506": {"description": "Dishevelled-related protein", "go_ids": ["GO:0016055"], "go_terms": ["GO:0016055:Wnt signaling pathway:P"], "name": "Dsh/Dvl-rel", "pathway_ids": ["R-MMU-8856828", "R-HSA-201681", "R-RNO-4641262", "R-CEL-5663220", "R-MMU-8856825", "R-HSA-8856828", "R-HSA-5368598", "R-XTR-8856825", "R-CEL-5099900", "R-MMU-5099900", "R-DME-4641258", "R-DME-350368", "R-MMU-201688", "R-XTR-4641262", "R-DME-4086400", "R-DME-2028269", "R-DME-350376", "R-DME-5099900", "R-DME-350411", "R-DME-4641262", "R-XTR-5099900", "R-RNO-201688", "R-HSA-4641262", "R-DME-5663220", "R-DME-4608870", "R-MMU-4608870", "R-DME-450728", "R-MMU-5663220", "R-XTR-8856828", "R-CEL-8856828", "R-RNO-4641258", "R-HSA-201688", "R-CEL-4641258", "R-DME-350369", "R-MMU-2028269", "R-RNO-4086400", "R-HSA-4086400", "R-MMU-4086400", "R-XTR-201688", "R-CEL-4086400", "R-HSA-5099900", "R-XTR-5663220", "R-DME-350480", "R-XTR-4641258", "R-HSA-9673324", "R-HSA-4641258", "R-RNO-5663220", "R-DME-201688", "R-MMU-4641258", "R-CEL-2028269", "R-CEL-201688", "R-HSA-4608870", "R-DME-209440", "R-HSA-8856825", "R-XTR-4086400", "R-MMU-4641262", "R-HSA-5663220", "R-CEL-8856825", "R-HSA-2028269", "R-XTR-2028269"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-4641258:r:Degradation of DVL", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-MMU-201688:r:WNT mediated activation of DVL", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-4086400:r:PCP/CE pathway", "R-DME-2028269:r:Signaling by Hippo", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-201688:r:WNT mediated activation of DVL", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-201688:r:WNT mediated activation of DVL", "R-CEL-4641258:r:Degradation of DVL", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-MMU-2028269:r:Signaling by Hippo", "R-RNO-4086400:r:PCP/CE pathway", "R-HSA-4086400:r:PCP/CE pathway", "R-MMU-4086400:r:PCP/CE pathway", "R-XTR-201688:r:WNT mediated activation of DVL", "R-CEL-4086400:r:PCP/CE pathway", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-XTR-4641258:r:Degradation of DVL", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DME-201688:r:WNT mediated activation of DVL", "R-MMU-4641258:r:Degradation of DVL", "R-CEL-2028269:r:Signaling by Hippo", "R-CEL-201688:r:WNT mediated activation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-4086400:r:PCP/CE pathway", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-2028269:r:Signaling by Hippo", "R-XTR-2028269:r:Signaling by Hippo"], "type": "Family"}, "IPR015507": {"description": "Ribosomal RNA large subunit methyltransferase E", "go_ids": ["GO:0008168", "GO:0001510"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0001510:RNA methylation:P"], "name": "rRNA-MeTfrase_E", "pathway_ids": ["R-MMU-6791226", "R-HSA-6793080", "R-HSA-6782315", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR015510": {"description": "Peptidoglycan recognition protein", "go_ids": [], "go_terms": [], "name": "PGRP", "pathway_ids": ["R-HSA-6798695", "R-RNO-6803157", "R-DME-214411", "R-BTA-6803157", "R-DME-214397", "R-DME-6798695", "R-DME-209266", "R-BTA-6798695", "R-DME-6803157", "R-HSA-6803157", "R-MMU-6798695", "R-DME-214399", "R-MMU-6803157", "R-DME-214416", "R-RNO-6798695", "R-DME-209171"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-BTA-6803157:r:Antimicrobial peptides", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-209266:r:Peptidoglycan bound PGRP-LC/LE oligomerises", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-MMU-6803157:r:Antimicrobial peptides", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-209171:r:Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE"], "type": "Family"}, "IPR015517": {"description": "Deoxycytidylate deaminase-related", "go_ids": [], "go_terms": [], "name": "dCMP_deaminase-rel", "pathway_ids": ["PWY-7210", "R-SCE-499943", "R-MMU-499943", "R-DME-499943", "R-SPO-499943", "R-HSA-499943", "R-RNO-499943", "R-CEL-499943"], "pathways": ["PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR015525": {"description": "Breast cancer type 2 susceptibility protein", "go_ids": ["GO:0006281", "GO:0000724"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0000724:double-strand break repair via homologous recombination:P"], "name": "BRCA2", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-RNO-5693579", "R-HSA-9704646", "R-RNO-5685939", "R-HSA-9709603", "R-MMU-5693616", "R-MMU-5685942", "R-HSA-5685939", "R-HSA-9709275", "R-RNO-5685942", "R-HSA-9709570", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-912446", "R-HSA-9763198", "R-MMU-5685939", "R-MMU-5693568", "R-RNO-5693616", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709275:r:Impaired BRCA2 translocation to the nucleus", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-912446:r:Meiotic recombination", "R-HSA-9763198:r:Impaired BRCA2 binding to SEM1 (DSS1)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Family"}, "IPR015526": {"description": "Frizzled/secreted frizzled-related protein", "go_ids": [], "go_terms": [], "name": "Frizzled/SFRP", "pathway_ids": ["R-DRE-5140745", "R-RNO-5140745", "R-HSA-373080", "R-MMU-8856828", "R-MMU-5632684", "R-GGA-4608870", "R-MMU-4641263", "R-DME-216217", "R-HSA-8856828", "R-DRE-4641263", "R-MMU-4086398", "R-MMU-5099900", "R-RNO-5635838", "R-RNO-5610787", "R-DME-4086400", "R-RNO-4641263", "R-DME-350376", "R-DRE-5610787", "R-DRE-4641262", "R-DME-350411", "R-DME-4641262", "R-MMU-5610787", "R-DME-209472", "R-CEL-4086398", "R-DME-5610787", "R-HSA-5140745", "R-DME-4608870", "R-MMU-5635838", "R-RNO-4086400", "R-DRE-5620922", "R-MMU-4086400", "R-DME-5140745", "R-MMU-5140745", "R-HSA-4608870", "R-HSA-5635838", "R-MMU-4641262", "R-CEL-4608870", "R-MMU-5620922", "R-DRE-4608870", "R-HSA-5620922", "R-DME-350379", "R-RNO-5632684", "R-HSA-201681", "R-RNO-4641262", "R-MMU-8856825", "R-RNO-5620922", "R-DME-350368", "R-DME-209338", "R-DME-209214", "R-DME-5635838", "R-CEL-5140745", "R-HSA-5610787", "R-HSA-4641262", "R-HSA-5340588", "R-RNO-8856828", "R-HSA-4086398", "R-DME-209387", "R-RNO-5099900", "R-MMU-4608870", "R-DME-450728", "R-DME-216119", "R-GGA-5099900", "R-HSA-3772470", "R-RNO-4608870", "R-DRE-5635838", "R-RNO-8856825", "R-DME-5620922", "R-HSA-4641263", "R-HSA-4086400", "R-HSA-5099900", 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complex", "R-DRE-5610787:r:Hedgehog 'off' state", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-209472:r:Assembly of receptor complex", "R-CEL-4086398:r:Ca2+ pathway", "R-DME-5610787:r:Hedgehog 'off' state", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5635838:r:Activation of SMO", "R-RNO-4086400:r:PCP/CE pathway", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-4086400:r:PCP/CE pathway", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5635838:r:Activation of SMO", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209214:r:Phosphorylation of SMO", "R-DME-5635838:r:Activation of SMO", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-4086398:r:Ca2+ pathway", "R-DME-209387:r:Phosphorylation of ARR", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-DME-216119:r:Activation of CI", "R-GGA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-DRE-5635838:r:Activation of SMO", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", 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"R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-1538133:r:G0 and Early G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Family"}, "IPR015649": {"description": "Schwannomin interacting protein 1, C-terminal", "go_ids": [], "go_terms": [], "name": "SCHIP_1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015654": {"description": "Mandelate racemase", "go_ids": ["GO:0018838"], "go_terms": ["GO:0018838:mandelate racemase activity:F"], "name": "Mandelate_racemase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015655": {"description": "Protein phosphatase 2C", "go_ids": ["GO:0004722", "GO:0006470"], "go_terms": ["GO:0004722:protein serine/threonine phosphatase activity:F", "GO:0006470:protein dephosphorylation:P"], "name": "PP2C", "pathway_ids": ["R-MMU-2173795", "R-HSA-9020702", "R-HSA-9705671", "R-HSA-168638", "R-HSA-9700645", "R-MMU-380972", "R-HSA-937042", "R-HSA-5689880", "R-MMU-450302", "R-MMU-5607764", "R-RNO-1169408", "R-MMU-9645460", "R-MMU-9020702", "R-MMU-937072", "R-HSA-1169408", "R-MMU-5357956", "R-MMU-937042", "R-BTA-380972", "R-HSA-450321", "R-HSA-2871837", "R-RNO-2173795", "R-MMU-5689880", "R-MMU-445989", "R-BTA-204174", "R-MMU-70895", "R-HSA-2173795", "R-HSA-450302", "R-MMU-975163", "R-BTA-2173795", "R-HSA-8878166", "R-MMU-168638", "R-HSA-937072", "R-HSA-5607764", "R-HSA-9617324", "R-HSA-380972", "R-CEL-2173795", "R-BTA-70895", "R-HSA-204174", "R-RNO-204174", "R-CEL-380972", "R-HSA-975163", "R-HSA-1660661", "R-MMU-1169408", "R-HSA-9645460", "R-MMU-450321", "R-HSA-70895", "R-MMU-8878166", "R-RNO-70895", "R-MMU-204174", "R-CEL-1169408", "R-HSA-5357956", "R-MMU-2871837", "R-RNO-380972", "R-HSA-9014325", "R-BTA-1169408", "R-HSA-9912529", "R-HSA-9725370", "R-HSA-445989"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation"], "type": "Family"}, "IPR015659": {"description": "Proline oxidase family", "go_ids": ["GO:0004657", "GO:0006562"], "go_terms": ["GO:0004657:proline dehydrogenase activity:F", "GO:0006562:L-proline catabolic process:P"], "name": "Proline_oxidase", "pathway_ids": ["PWY-6922", "PWY-5737", "R-DME-389661", "R-SPO-70688", "R-CEL-70688", "R-HSA-70688", "R-SPO-389661", "R-SCE-70688", "R-DDI-70688", "R-DME-70688", "R-MMU-70688", "R-MMU-389661", "R-DDI-389661", "R-CEL-389661", "R-RNO-389661", "R-HSA-389661", "R-RNO-70688", "R-SCE-389661"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-5737:t:(5R)-carbapenem carboxylate biosynthesis", "R-DME-389661:r:Glyoxylate metabolism and glycine degradation", "R-SPO-70688:r:Proline catabolism", "R-CEL-70688:r:Proline catabolism", "R-HSA-70688:r:Proline catabolism", "R-SPO-389661:r:Glyoxylate metabolism and glycine degradation", "R-SCE-70688:r:Proline catabolism", "R-DDI-70688:r:Proline catabolism", "R-DME-70688:r:Proline catabolism", "R-MMU-70688:r:Proline catabolism", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-DDI-389661:r:Glyoxylate metabolism and glycine degradation", "R-CEL-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-70688:r:Proline catabolism", "R-SCE-389661:r:Glyoxylate metabolism and glycine degradation"], "type": "Family"}, "IPR015660": {"description": "Achaete-scute transcription factor-related", "go_ids": ["GO:0003700", "GO:0006357"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "MASH1/Ascl1a-like", "pathway_ids": ["R-HSA-9031628"], "pathways": ["R-HSA-9031628:r:NGF-stimulated transcription"], "type": "Family"}, "IPR015661": {"description": "Mitotic spindle checkpoint protein Bub1/Mad3", "go_ids": ["GO:0007094"], "go_terms": ["GO:0007094:mitotic spindle assembly checkpoint signaling:P"], "name": "Bub1/Mad3", "pathway_ids": ["R-SPO-141430", "R-MMU-2500257", "R-HSA-176409", "R-MMU-176409", "R-MMU-141444", "R-HSA-2467813", "R-HSA-2500257", "R-MMU-2467813", "R-SCE-141430", "R-MMU-179409", "R-HSA-141444", "R-MMU-68877", "R-HSA-9648025", "R-HSA-174184", "R-SPO-179409", "R-CEL-141430", "R-DDI-179409", "R-HSA-141430", "R-MMU-174184", "R-DDI-176409", "R-DDI-174184", "R-HSA-68877", "R-MMU-141430", "R-DDI-141430", "R-HSA-5663220", "R-HSA-179409", "R-MMU-9648025", "R-MMU-5663220"], "pathways": ["R-SPO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SCE-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-CEL-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR015662": {"description": "Promotilin", "go_ids": [], "go_terms": [], "name": "Promotilin", "pathway_ids": ["R-HSA-375276", "R-HSA-416476"], "pathways": ["R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-416476:r:G alpha (q) signalling events"], "type": "Family"}, "IPR015664": {"description": "P53-induced protein", "go_ids": [], "go_terms": [], "name": "P53_induced", "pathway_ids": ["R-DRE-6809371", "R-HSA-6803205", "R-MMU-6809371", "R-HSA-6809371"], "pathways": ["R-DRE-6809371:r:Formation of the cornified envelope", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Family"}, "IPR015666": {"description": "Sarcoplasmic reticulum histidine-rich calcium-binding protein", "go_ids": ["GO:0005509"], "go_terms": ["GO:0005509:calcium ion binding:F"], "name": "HRC", "pathway_ids": ["R-HSA-8957275", "R-HSA-381426"], "pathways": ["R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR015667": {"description": "Telethonin", "go_ids": [], "go_terms": [], "name": "Telethonin", "pathway_ids": ["R-MMU-390522", "R-BTA-390522", "R-HSA-390522"], "pathways": ["R-MMU-390522:r:Striated Muscle Contraction", "R-BTA-390522:r:Striated Muscle Contraction", "R-HSA-390522:r:Striated Muscle Contraction"], "type": "Family"}, "IPR015668": {"description": "B Cell Lymphoma 9", "go_ids": ["GO:0003713", "GO:0008013", "GO:0060070"], "go_terms": ["GO:0003713:transcription coactivator activity:F", "GO:0008013:beta-catenin binding:F", "GO:0060070:canonical Wnt signaling pathway:P"], "name": "Bcl-9/Bcl-9l", "pathway_ids": ["R-MMU-201722", "R-HSA-201722", "R-HSA-3769402", "R-DRE-201722"], "pathways": ["R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex"], "type": "Family"}, "IPR015669": {"description": "Endothelial protein C receptor", "go_ids": ["GO:0038023"], "go_terms": ["GO:0038023:signaling receptor activity:F"], "name": "Endothetial_C_recpt", "pathway_ids": ["R-RNO-140875", "R-HSA-202733", "R-HSA-140875", "R-BTA-140875", "R-RNO-202733", "R-MMU-202733", "R-MMU-140875", "R-BTA-202733"], "pathways": ["R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR015671": {"description": "GLTSCR protein, conserved domain", "go_ids": [], "go_terms": [], "name": "GSCR1_dom", "pathway_ids": ["R-HSA-9933947", "R-MMU-9933947"], "pathways": ["R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex"], "type": "Domain"}, "IPR015672": {"description": "The Golgi pH regulator/GPCR-type G protein", "go_ids": [], "go_terms": [], "name": "GPHR/GTG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015673": {"description": "Enamelin", "go_ids": [], "go_terms": [], "name": "Enamelin", "pathway_ids": ["R-HSA-381426", "R-MMU-8957275", "R-MMU-381426", "R-HSA-8957275"], "pathways": ["R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation"], "type": "Family"}, "IPR015675": {"description": "Secretin precursor", "go_ids": [], "go_terms": [], "name": "Prosecretin", "pathway_ids": ["R-HSA-420092", "R-HSA-418555", "R-RNO-420092", "R-MMU-418555", "R-MMU-420092"], "pathways": ["R-HSA-420092:r:Glucagon-type ligand receptors", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-420092:r:Glucagon-type ligand receptors", "R-MMU-418555:r:G alpha (s) signalling events", "R-MMU-420092:r:Glucagon-type ligand receptors"], "type": "Family"}, "IPR015676": {"description": "Tob1/2", "go_ids": [], "go_terms": [], "name": "Tob1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015679": {"description": "Phospholipase D family", "go_ids": [], "go_terms": [], "name": "PLipase_D_fam", "pathway_ids": ["PWY-3561", "PWY-7039", "R-HSA-6798695", "R-SPO-6798695", "R-SPO-2029485", "R-RNO-1483166", "R-MMU-8980692", "R-SCE-2029485", "R-RNO-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-HSA-2029485", "R-RNO-9013149", "R-MMU-9013404", "R-HSA-1483166", "R-HSA-1483148", "R-DDI-9013149", "R-RNO-2029485", "R-SCE-8980692", "R-SPO-1483166", "R-HSA-9013148", "R-MMU-2029485", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-DDI-2029485", "R-DDI-6798695", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-1483166", "R-HSA-9013149", "R-HSA-8980692", "R-DDI-1483166", "R-MMU-6798695", "R-DDI-9013404", "R-MMU-9013149", "R-SCE-1483166", "R-RNO-6798695"], "pathways": ["PWY-3561:t:choline biosynthesis III", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-1483166:r:Synthesis of PA", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1483148:r:Synthesis of PG", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-1483166:r:Synthesis of PA", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DDI-1483166:r:Synthesis of PA", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-SCE-1483166:r:Synthesis of PA", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR015683": {"description": "Ionotropic glutamate receptor", "go_ids": [], "go_terms": [], "name": "Ionotropic_Glu_rcpt", "pathway_ids": ["R-MMU-204005", "R-DME-399710", 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"R-MMU-399719", "R-RNO-416993"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-DME-399710:r:Activation of AMPA receptors", "R-RNO-451307:r:Activation of Na-permeable kainate receptors", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-MMU-399710:r:Activation of AMPA receptors", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-451307:r:Activation of Na-permeable kainate receptors", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-5694530:r:Cargo concentration in the ER", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-RNO-399710:r:Activation of AMPA receptors", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-500657:r:Presynaptic function of Kainate receptors", "R-HSA-9620244:r:Long-term potentiation", "R-CEL-399710:r:Activation of AMPA receptors", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DME-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-451307:r:Activation of Na-permeable kainate receptors", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-399710:r:Activation of AMPA receptors", "R-CEL-500657:r:Presynaptic function of Kainate receptors", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-451307:r:Activation of Na-permeable kainate receptors", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors"], "type": "Family"}, "IPR015700": {"description": "DNA-directed RNA polymerase III subunit RPC1", "go_ids": [], "go_terms": [], "name": "RPC1", 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"R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-CEL-112382", "R-HSA-9670095", "R-HSA-167160", "R-CEL-6782135", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-MMU-73772", "R-DDI-113418", "R-MMU-72086", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-DME-5578749", "R-DME-77075", "R-DME-73779", "R-BTA-5578749", "R-CEL-73772", "R-DME-9770562", "R-DME-73776", "R-BTA-6781823", "R-MMU-6781823", "R-HSA-203927", "R-DDI-73772", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-DDI-76042", "R-MMU-73776", "R-HSA-73780", "R-CEL-72163", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-DME-113418", "R-HSA-76071", "R-HSA-72203", "R-CEL-75955", "R-MMU-6796648", "R-BTA-72165", "R-HSA-9770562", "R-HSA-167243", "R-DRE-73772", "R-SCE-6781823", "R-MMU-76071", "R-BTA-674695", "R-SCE-9018519", "R-BTA-6803529", "R-DME-76066", "R-HSA-167290", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", 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"R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-72086:r:mRNA Capping", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", 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"Impact YigZ-like", "go_ids": [], "go_terms": [], "name": "Impact_YigZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015797": {"description": "NUDIX hydrolase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "NUDIX_hydrolase-like_dom_sf", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-6798695", "R-SCE-9969896", "R-MMU-2393930", "R-HSA-5419276", "R-HSA-110357", "R-MMU-9770562", "R-CEL-450385", "R-SCE-196807", "R-HSA-73856", "R-BTA-480985", "R-HSA-72187", "R-HSA-499943", "R-RNO-3299685", "R-MMU-110331", "R-SCE-450385", "R-RNO-73856", "R-HSA-110331", "R-RNO-9033241", "R-HSA-380994", "R-RNO-5419276", "R-DRE-6798695", "R-SSC-480985", "R-SPO-1855167", "R-MMU-430039", "R-HSA-5368286", "R-BTA-1855167", "R-SCE-9033241", "R-CEL-196807", "R-RNO-9937383", "R-HSA-5389840", "R-SPO-110331", "R-MMU-110357", "R-SCE-1855167", "R-MMU-480985", "R-HSA-430039", "R-MMU-9748787", 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3' exoribonuclease", "R-MMU-9748787:r:Azathioprine ADME", "R-CFA-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-110331:r:Cleavage of the damaged purine", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-HSA-9748787:r:Azathioprine ADME", "R-MMU-450604:r:KSRP (KHSRP) binds and 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"R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-CEL-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-BTA-196807:r:Nicotinate metabolism", "R-RNO-3295583:r:TRP channels", "R-SPO-196819:r:Vitamin B1 (thiamin) metabolism", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-DRE-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-DRE-9770562:r:mRNA Polyadenylation", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-GGA-9033241:r:Peroxisomal protein import", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9608287:r:Defective MUTYH substrate binding", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-9608290:r:Defective MUTYH substrate processing", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9033241:r:Peroxisomal protein import", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-390918:r:Peroxisomal lipid metabolism", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SPO-9033241:r:Peroxisomal protein import", "R-RNO-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-HSA-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-3295583:r:TRP channels", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-3295583:r:TRP channels"], "type": "Homologous_superfamily"}, "IPR015798": {"description": "Copper amine oxidase, catalytic domain", "go_ids": ["GO:0005507", "GO:0008131", "GO:0009308", "GO:0048038"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0008131:primary methylamine oxidase activity:F", "GO:0009308:amine metabolic process:P", "GO:0048038:quinone binding:F"], "name": "Cu_amine_oxidase_C", "pathway_ids": ["R-RNO-211945", "R-HSA-6798695", "R-MMU-6798695", "R-BTA-211945", "R-HSA-211945", "R-RNO-6798695", "R-MMU-211945"], "pathways": ["R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-211945:r:Phase I - Functionalization of compounds", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-211945:r:Phase I - Functionalization of compounds"], "type": "Domain"}, "IPR015799": {"description": "Influenza matrix M1, N-terminal subdomain 2", "go_ids": ["GO:0003723", "GO:0005198"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005198:structural molecule activity:F"], "name": "Flu_matrix_M1_N_sub2", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168288", "R-HSA-168275", "R-HSA-168316", "R-HSA-168298", "R-HSA-168330", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-168298:r:Release", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Homologous_superfamily"}, "IPR015800": {"description": "Copper amine oxidase, N2-terminal", "go_ids": ["GO:0005507", "GO:0008131", "GO:0009308", "GO:0048038"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0008131:primary methylamine oxidase activity:F", "GO:0009308:amine metabolic process:P", "GO:0048038:quinone binding:F"], "name": "Cu_amine_oxidase_N2", "pathway_ids": ["R-RNO-211945", "R-HSA-6798695", "R-MMU-6798695", "R-BTA-211945", "R-HSA-211945", "R-RNO-6798695", "R-MMU-211945"], "pathways": ["R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-211945:r:Phase I - Functionalization of compounds", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-211945:r:Phase I - Functionalization of compounds"], "type": "Domain"}, "IPR015802": {"description": "Copper amine oxidase, N3-terminal", "go_ids": ["GO:0005507", "GO:0008131", "GO:0009308", "GO:0048038"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0008131:primary methylamine oxidase activity:F", "GO:0009308:amine metabolic process:P", "GO:0048038:quinone binding:F"], "name": "Cu_amine_oxidase_N3", "pathway_ids": ["R-RNO-211945", "R-HSA-6798695", "R-MMU-6798695", "R-BTA-211945", "R-HSA-211945", "R-RNO-6798695", "R-MMU-211945"], "pathways": ["R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-211945:r:Phase I - Functionalization of compounds", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-211945:r:Phase I - Functionalization of compounds"], "type": "Domain"}, "IPR015803": {"description": "Cysteine-tRNA ligase", "go_ids": ["GO:0004817", "GO:0005524", "GO:0006423"], "go_terms": ["GO:0004817:cysteine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0006423:cysteinyl-tRNA aminoacylation:P"], "name": "Cys-tRNA-ligase", "pathway_ids": ["R-HSA-9725370", "R-HSA-379716", "R-HSA-379726"], "pathways": ["R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Family"}, "IPR015806": {"description": "Pyruvate kinase, insert domain superfamily", "go_ids": ["GO:0004743", "GO:0006096"], "go_terms": ["GO:0004743:pyruvate kinase activity:F", "GO:0006096:glycolytic process:P"], "name": "Pyrv_Knase_insert_dom_sf", "pathway_ids": ["PWY-1042", "PWY-7383", "PWY-8404", "PWY-2221", "PWY-6886", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-HSA-6798695", "R-HSA-163765", "R-MMU-70268", "R-MMU-70171", "R-SPO-6798695", "R-CFA-70171", "R-DDI-6798695", "R-SCE-70171", "R-DDI-9861718", "R-DME-6798695", "R-SPO-70268", "R-MMU-9861718", "R-DME-70171", "R-SCE-6798695", "R-HSA-210745", "R-HSA-9764725", "R-DDI-70171", "R-DME-9861718", "R-HSA-70268", "R-HSA-9861718", "R-DME-70268", "R-RNO-70171", "R-GGA-352882", "R-RNO-70268", "R-DDI-70268", "R-CFA-70268", "R-MMU-6798695", "R-HSA-9692914", "R-HSA-70171", "R-SPO-70171", "R-SCE-70268"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-MMU-70268:r:Pyruvate metabolism", "R-MMU-70171:r:Glycolysis", "R-SPO-6798695:r:Neutrophil degranulation", "R-CFA-70171:r:Glycolysis", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-70171:r:Glycolysis", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-SPO-70268:r:Pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DME-70171:r:Glycolysis", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DDI-70171:r:Glycolysis", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-DME-70268:r:Pyruvate metabolism", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-RNO-70268:r:Pyruvate metabolism", "R-DDI-70268:r:Pyruvate metabolism", "R-CFA-70268:r:Pyruvate metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Homologous_superfamily"}, "IPR015807": {"description": "Histidine-tRNA ligase", "go_ids": ["GO:0004821", "GO:0005524", "GO:0006427"], "go_terms": ["GO:0004821:histidine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0006427:histidyl-tRNA aminoacylation:P"], "name": "His-tRNA-ligase", "pathway_ids": ["R-HSA-379716", "R-HSA-379726"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Family"}, "IPR015810": {"description": "Photosynthetic reaction centre, H subunit, N-terminal", "go_ids": ["GO:0019684", "GO:0030077"], "go_terms": ["GO:0019684:photosynthesis, light reaction:P", "GO:0030077:plasma membrane light-harvesting complex:C"], "name": "Photo_RC_H_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015811": {"description": "Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 1", "go_ids": ["GO:0015948", "GO:0050524"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_asu_N_sub1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015812": {"description": "Integrin beta subunit", "go_ids": [], "go_terms": [], "name": "Integrin_bsu", "pathway_ids": ["R-DME-2173789", "R-HSA-8874081", "R-MMU-210991", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-MMU-9013408", "R-MMU-210990", "R-CEL-3000178", "R-HSA-9856532", "R-MMU-445355", "R-CEL-1566948", "R-DME-445355", "R-MMU-3000170", "R-CEL-446343", "R-RNO-9634597", "R-RNO-210990", "R-DME-446343", "R-MMU-202733", "R-CEL-198933", "R-HSA-8875513", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-446107", "R-HSA-6802955", "R-HSA-210991", "R-RNO-446343", "R-DME-9013149", "R-HSA-6802948", "R-DME-210991", "R-RNO-445144", "R-RNO-1566977", "R-BTA-1566948", "R-DME-114608", "R-MMU-9634597", "R-CEL-5674135", "R-HSA-9609690", "R-HSA-8941332", "R-HSA-447041", "R-DME-216083", "R-MMU-9013423", "R-HSA-2022090", "R-MMU-216083", "R-HSA-445144", "R-MMU-354192", "R-MMU-9860927", "R-MMU-446107", "R-HSA-9656223", "R-HSA-9634597", "R-MMU-5674135", "R-RNO-216083", "R-RNO-9860927", "R-HSA-9013423", "R-RNO-8874081", "R-HSA-114608", "R-MMU-8874081", "R-RNO-354192", "R-CEL-354192", "R-RNO-5674135", "R-BTA-2129379", "R-RNO-2173789", "R-CEL-9013423", "R-MMU-3000157", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-3000170", "R-MMU-1566977", "R-DME-202733", "R-RNO-446107", "R-DME-6798695", "R-DME-446107", "R-MMU-354194", "R-MMU-1236973", "R-RNO-9013423", "R-CEL-445355", "R-HSA-5663220", "R-MMU-9013149", "R-RNO-3000170", "R-BTA-216083", "R-HSA-202733", "R-HSA-6798695", "R-HSA-5674135", "R-HSA-166016", "R-DME-198933", "R-CEL-6798695", "R-CEL-354194", "R-BTA-6798695", "R-RNO-3000157", "R-RNO-9013149", "R-MMU-4420097", "R-MMU-9013404", "R-HSA-9927418", "R-BTA-2173789", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-HSA-446343", "R-RNO-202733", "R-CEL-202733", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-3000178", "R-HSA-2173789", "R-CEL-216083", "R-BTA-198933", "R-CEL-9860927", "R-RNO-198933", "R-CEL-1236973", "R-MMU-166016", "R-CEL-114608", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-RNO-1566948", "R-DME-354192", "R-BTA-166016", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-75892", "R-MMU-198933", "R-DME-445144", "R-HSA-198933", "R-MMU-8875513", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-372708", "R-RNO-4420097", "R-MMU-114608", "R-HSA-9725554", "R-HSA-3000157", "R-CEL-1566977", "R-BTA-3000178", "R-HSA-1566948", "R-DME-9860927", "R-RNO-354194", "R-RNO-2129379", "R-CEL-9013149", "R-RNO-114608", "R-BTA-202733", "R-MMU-372708", "R-HSA-210990", "R-RNO-8875513", "R-DME-1236973", "R-HSA-416700", "R-HSA-6802946", "R-DME-2129379", "R-HSA-9938206", "R-MMU-446343", "R-HSA-354192", "R-CEL-210991", "R-HSA-216083", "R-HSA-445355", "R-RNO-210991", "R-CEL-445144", "R-HSA-1566977", "R-HSA-9927432", "R-HSA-354194", "R-HSA-9679191", "R-HSA-9830674", "R-DME-3000170", "R-CEL-4420097", "R-DME-9013423", "R-MMU-2129379"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-445355:r:Smooth Muscle Contraction", "R-CEL-1566948:r:Elastic fibre formation", "R-DME-445355:r:Smooth Muscle Contraction", "R-MMU-3000170:r:Syndecan interactions", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-9634597:r:GPER1 signaling", "R-RNO-210990:r:PECAM1 interactions", "R-DME-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-210991:r:Basigin interactions", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-1566977:r:Fibronectin matrix formation", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-HSA-447041:r:CHL1 interactions", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000157:r:Laminin interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-1566948:r:Elastic fibre formation", "R-DME-354192:r:Integrin signaling", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-CEL-1566977:r:Fibronectin matrix formation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-1566948:r:Elastic fibre formation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-354192:r:Integrin signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-210991:r:Basigin interactions", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Family"}, "IPR015813": {"description": "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Pyrv/PenolPyrv_kinase-like_dom", "pathway_ids": ["R-HSA-6798695", "R-HSA-163765", "R-MMU-70268", "R-MMU-70171", "R-SPO-6798695", "R-CFA-70171", "R-DDI-6798695", "R-SCE-70171", "R-DDI-9861718", "R-DME-6798695", "R-SPO-70268", "R-MMU-9861718", "R-DME-70171", "R-SCE-6798695", "R-HSA-210745", "R-HSA-9764725", "R-DDI-70171", "R-DME-9861718", "R-HSA-70268", "R-HSA-9861718", "R-DME-70268", "R-RNO-70171", "R-GGA-352882", "R-RNO-70268", "R-DDI-70268", "R-CFA-70268", "R-MMU-6798695", "R-HSA-9692914", "R-HSA-70171", "R-SPO-70171", "R-SCE-70268"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-MMU-70268:r:Pyruvate metabolism", "R-MMU-70171:r:Glycolysis", "R-SPO-6798695:r:Neutrophil degranulation", "R-CFA-70171:r:Glycolysis", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-70171:r:Glycolysis", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-SPO-70268:r:Pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DME-70171:r:Glycolysis", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DDI-70171:r:Glycolysis", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-DME-70268:r:Pyruvate metabolism", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-RNO-70268:r:Pyruvate metabolism", "R-DDI-70268:r:Pyruvate metabolism", "R-CFA-70268:r:Pyruvate metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Homologous_superfamily"}, "IPR015814": {"description": "Phosphogluconate dehydrogenase, NAD-binding, putative, C-terminal", "go_ids": [], "go_terms": [], "name": "Pgluconate_DH_NAD-bd_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015815": {"description": "3-hydroxyisobutyrate dehydrogenase-related", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "HIBADH-related", "pathway_ids": ["R-DDI-70895", "R-BTA-70895", "R-HSA-70895", "R-DME-70895", "R-MMU-70895", "R-CEL-70895", "R-RNO-70895"], "pathways": ["R-DDI-70895:r:Branched-chain amino acid catabolism", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-DME-70895:r:Branched-chain amino acid catabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Family"}, "IPR015816": {"description": "Vitellinogen, beta-sheet N-terminal", "go_ids": ["GO:0005319", "GO:0006869"], "go_terms": ["GO:0005319:lipid carrier activity:F", "GO:0006869:lipid transport:P"], "name": "Vitellinogen_b-sht_N", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-DME-8964041", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-SSC-8964041", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-HSA-202733", "R-RNO-5686938", "R-SSC-8963888", "R-MMU-3000471", "R-MMU-8964041", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-DRE-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-RNO-8964041", "R-HSA-8957275", "R-SSC-8866423", "R-RNO-3000480", "R-HSA-8964038", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-DME-8964041:r:LDL remodeling", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-SSC-8964041:r:LDL remodeling", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-SSC-8963888:r:Chylomicron assembly", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-MMU-8964041:r:LDL remodeling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-DRE-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-RNO-8964041:r:LDL remodeling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-8866423:r:VLDL assembly", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-8964038:r:LDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Homologous_superfamily"}, "IPR015817": {"description": "Vitellinogen, open beta-sheet, subdomain 1", "go_ids": ["GO:0005319"], "go_terms": ["GO:0005319:lipid carrier activity:F"], "name": "Vitellinogen_open_b-sht_sub1", "pathway_ids": ["R-HSA-3000484", "R-HSA-3000497", "R-HSA-8866423", "R-HSA-3000480", "R-HSA-8856828", "R-HSA-8964026", "R-HSA-432142", "R-HSA-8963901", "R-HSA-9707616", "R-HSA-8963888", "R-HSA-8964041", "R-HSA-8964046", "R-HSA-8964038", "R-HSA-3000471", "R-HSA-8856825", "R-HSA-8957275", "R-HSA-5686938", "R-HSA-381426", "R-HSA-975634", "R-HSA-202733"], "pathways": ["R-HSA-3000484:r:Scavenging by Class F Receptors", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-8866423:r:VLDL assembly", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-8963901:r:Chylomicron remodeling", "R-HSA-9707616:r:Heme signaling", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-HSA-8964046:r:VLDL clearance", "R-HSA-8964038:r:LDL clearance", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Homologous_superfamily"}, "IPR015819": {"description": "Lipid transport protein, beta-sheet shell", "go_ids": ["GO:0005319", "GO:0006869"], "go_terms": ["GO:0005319:lipid carrier activity:F", "GO:0006869:lipid transport:P"], "name": "Lipid_transp_b-sht_shell", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-DME-8964041", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-SSC-8964041", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-HSA-202733", "R-RNO-5686938", "R-SSC-8963888", "R-MMU-3000471", "R-MMU-8964041", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-DRE-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-RNO-8964041", "R-HSA-8957275", "R-SSC-8866423", "R-RNO-3000480", "R-HSA-8964038", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-DME-8964041:r:LDL remodeling", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-SSC-8964041:r:LDL remodeling", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-SSC-8963888:r:Chylomicron assembly", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-MMU-8964041:r:LDL remodeling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-DRE-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-RNO-8964041:r:LDL remodeling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-8866423:r:VLDL assembly", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-8964038:r:LDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Homologous_superfamily"}, "IPR015820": {"description": "TyA domain", "go_ids": ["GO:0003723", "GO:0005737"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005737:cytoplasm:C"], "name": "TYA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015823": {"description": "Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2", "go_ids": ["GO:0015948", "GO:0050524"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_asu_N_sub2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015824": {"description": "Phosphoglycerate kinase, N-terminal", "go_ids": ["GO:0004618", "GO:0006096"], "go_terms": ["GO:0004618:phosphoglycerate kinase activity:F", "GO:0006096:glycolytic process:P"], "name": "Phosphoglycerate_kinase_N", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-6886", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-MMU-70171", "R-RNO-70263", "R-SCE-70171", "R-SSC-70263", "R-BTA-70171", "R-DME-70171", "R-PFA-70263", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-DME-70263", "R-PFA-70171", "R-DDI-70263", "R-RNO-70171", "R-GGA-352882", "R-SSC-70171", "R-HSA-70263", "R-CEL-70263", "R-BTA-70263", "R-SCE-70263", "R-HSA-9636667", "R-HSA-70171", "R-SPO-70171", "R-SPO-70263"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-RNO-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-SSC-70263:r:Gluconeogenesis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-PFA-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-PFA-70171:r:Glycolysis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-SSC-70171:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR015827": {"description": "Alpha-(1,6)-fucosyltransferase", "go_ids": ["GO:0009101", "GO:0008424", "GO:0016020", "GO:0032580"], "go_terms": ["GO:0009101:glycoprotein biosynthetic process:P", "GO:0008424:glycoprotein 6-alpha-L-fucosyltransferase activity:F", "GO:0016020:membrane:C", "GO:0032580:Golgi cisterna membrane:C"], "name": "Fut8", "pathway_ids": ["PWY-7426", "R-RNO-975578", "R-MMU-975578", "R-DME-975578", "R-XTR-975578", "R-HSA-975578", "R-HSA-9694548", "R-CEL-975578"], "pathways": ["PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-XTR-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-9694548:r:Maturation of spike protein", "R-CEL-975578:r:Reactions specific to the complex N-glycan synthesis pathway"], "type": "Family"}, "IPR015828": {"description": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "go_ids": ["GO:0006120"], "go_terms": ["GO:0006120:mitochondrial electron transport, NADH to ubiquinone:P"], "name": "NDUFA10", "pathway_ids": ["R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-MMU-611105", "R-MMU-6799198", "R-DME-6799198", "R-HSA-6799198", "R-RNO-6799198"], "pathways": ["R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR015832": {"description": "MTH_1235/AF_1403/MJ1458", "go_ids": [], "go_terms": [], "name": "MTH_1235-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015833": {"description": "DNA-directed DNA polymerase, family B, mitochondrial linear plasmid", "go_ids": ["GO:0003677", "GO:0003887", "GO:0005739", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0005739:mitochondrion:C", "GO:0006260:DNA replication:P"], "name": "DNA-dir_DNA_pol_B_mt_lin_plsmd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015834": {"description": "Uncharacterised conserved protein UCP016642", "go_ids": [], "go_terms": [], "name": "UCP016642", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015835": {"description": "Hydroxymethyl pyrimidine (HMP)/thiamine binding protein", "go_ids": ["GO:0030975"], "go_terms": ["GO:0030975:thiamine binding:F"], "name": "HMP/thiamine-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015837": {"description": "Uncharacterised conserved protein UCP026622, CAAX protease-type", "go_ids": [], "go_terms": [], "name": "UCP026622_CAAX_protease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015838": {"description": "Uncharacterised conserved protein UCP027923, rubrerythrin-type", "go_ids": [], "go_terms": [], "name": "UCP027923_rubrerythrin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015839": {"description": "Bifunctional chloromethane dehalogenation methyltransferase corrinoid-binding protein CmuA", "go_ids": [], "go_terms": [], "name": "CmuA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015840": {"description": "DNA methyase, ParB domain-containing", "go_ids": [], "go_terms": [], "name": "DNA_MeTrfase_ParB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015841": {"description": "RNA-directed RNA polymerase, tospovirus", "go_ids": [], "go_terms": [], "name": "RNA-dir_pol_tospovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015842": {"description": "RNA-directed RNA polymerase, tenuivirus", "go_ids": [], "go_terms": [], "name": "RNA-dir_pol_tenuivirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015843": {"description": "RNA-directed RNA polymerase, nairovirus", "go_ids": [], "go_terms": [], "name": "RNA-dir_pol_nairovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015844": {"description": "Pantothenate kinase, acetyl-CoA regulated, two-domain type", "go_ids": ["GO:0004594", "GO:0015937"], "go_terms": ["GO:0004594:pantothenate kinase activity:F", "GO:0015937:coenzyme A biosynthetic process:P"], "name": "PanK_long", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664", "R-MMU-199220", "R-RNO-199220", "R-HSA-199220"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Family"}, "IPR015845": {"description": "Agropine synthesis reductase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Mas1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015847": {"description": "Exoribonuclease, phosphorolytic domain 2", "go_ids": [], "go_terms": [], "name": "ExoRNase_PH_dom2", "pathway_ids": ["R-BTA-450604", "R-MMU-450385", "R-DRE-450385", "R-HSA-9930044", "R-CEL-450385", "R-BTA-450385", "R-DDI-6791226", "R-MMU-429958", "R-RNO-450513", "R-SPO-9930044", "R-RNO-9930044", "R-SCE-450385", "R-RNO-450604", "R-DRE-9930044", "R-SCE-429958", "R-HSA-380994", "R-HSA-9836573", "R-SCE-6791226", "R-CEL-429958", "R-RNO-450385", "R-CEL-6791226", "R-HSA-429958", "R-SPO-429958", "R-MMU-9930044", "R-MMU-6791226", "R-BTA-429958", "R-DDI-429958", "R-DRE-450513", "R-BTA-6791226", "R-BTA-450513", "R-DRE-450604", "R-SCE-450513", "R-DRE-429958", "R-CEL-450513", "R-BTA-9930044", "R-RNO-6791226", "R-HSA-450385", "R-RNO-429958", "R-MMU-450513", "R-HSA-6791226", "R-DDI-450385", "R-MMU-450604", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-DDI-450513", "R-SPO-6791226", "R-DDI-9930044"], "pathways": ["R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-9930044:r:Nuclear RNA decay", "R-RNO-9930044:r:Nuclear RNA decay", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DRE-9930044:r:Nuclear RNA decay", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DDI-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DRE-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-9930044:r:Nuclear RNA decay", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-DDI-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9930044:r:Nuclear RNA decay"], "type": "Domain"}, "IPR015848": {"description": "Polyribonucleotide nucleotidyltransferase, RNA-binding domain", "go_ids": ["GO:0003723", "GO:0006396"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006396:RNA processing:P"], "name": "PNPase_PH_RNA-bd_bac/org-type", "pathway_ids": ["R-HSA-9836573"], "pathways": ["R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Domain"}, "IPR015849": {"description": "Amyloidogenic glycoprotein, heparin-binding", "go_ids": ["GO:0008201"], "go_terms": ["GO:0008201:heparin binding:F"], "name": "Amyloid_glyco_heparin-bd", "pathway_ids": ["R-MMU-416476", "R-SSC-432720", "R-DME-381426", "R-HSA-879415", "R-MMU-9837999", "R-MMU-444473", "R-DME-8957275", "R-HSA-3000178", "R-HSA-977225", "R-HSA-933542", "R-RNO-444473", "R-SSC-114608", "R-HSA-8862803", "R-CEL-3000178", "R-HSA-416476", "R-MMU-933542", "R-RNO-9609523", "R-DME-3000178", "R-MMU-418594", "R-MMU-8957275", "R-RNO-114608", "R-RNO-418594", "R-CEL-416476", "R-HSA-114608", "R-CEL-9609523", "R-MMU-445989", "R-MMU-3000178", "R-RNO-8957275", "R-SSC-933542", "R-MMU-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-444473", "R-DME-9609523", "R-HSA-9837999", "R-MMU-432720", "R-HSA-9609523", "R-MMU-9609523", "R-SSC-445989", "R-RNO-416476", "R-RNO-3000178", "R-HSA-381426", "R-SSC-3000178", "R-HSA-844456", "R-SSC-381426", "R-SSC-8957275", "R-RNO-432720", "R-HSA-432720", "R-DME-114608", "R-DME-9837999", "R-HSA-9660826", "R-MMU-879415", "R-HSA-445989", "R-SSC-9609523", "R-CEL-114608", "R-RNO-9837999", "R-SSC-879415", "R-RNO-381426", "R-HSA-418594", "R-RNO-879415", "R-RNO-445989", "R-SSC-9837999", "R-HSA-8957275", "R-RNO-933542", "R-MMU-114608"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-SSC-114608:r:Platelet degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-3000178:r:ECM proteoglycans", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-416476:r:G alpha (q) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-HSA-844456:r:The NLRP3 inflammasome", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-114608:r:Platelet degranulation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-114608:r:Platelet degranulation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR015854": {"description": "ABC transporter, lipoprotein release, LolD-like", "go_ids": [], "go_terms": [], "name": "ABC_transpr_LolD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR015864": {"description": "FAD synthetase", "go_ids": ["GO:0003919", "GO:0009231"], "go_terms": ["GO:0003919:FMN adenylyltransferase activity:F", "GO:0009231:riboflavin biosynthetic process:P"], "name": "FAD_synthase", "pathway_ids": ["PWY-7863", "PWY-6168", "PWY-5523", "PWY-6167"], "pathways": ["PWY-7863:t:roseoflavin biosynthesis", "PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-5523:t:5,6-dimethylbenzimidazole biosynthesis I (aerobic)", "PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Domain"}, "IPR015865": {"description": "Riboflavin kinase domain, bacterial/eukaryotic", "go_ids": ["GO:0008531", "GO:0009398"], "go_terms": ["GO:0008531:riboflavin kinase activity:F", "GO:0009398:FMN biosynthetic process:P"], "name": "Riboflavin_kinase_bac/euk", "pathway_ids": ["PWY-7863", "PWY-6168", "PWY-5523", "R-SCE-196843", "R-DME-196843", "R-MMU-196843", "R-HSA-196843", "R-SPO-196843"], "pathways": ["PWY-7863:t:roseoflavin biosynthesis", "PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-5523:t:5,6-dimethylbenzimidazole biosynthesis I (aerobic)", "R-SCE-196843:r:Vitamin B2 (riboflavin) metabolism", "R-DME-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-SPO-196843:r:Vitamin B2 (riboflavin) metabolism"], "type": "Domain"}, "IPR015866": {"description": "Serine-tRNA synthetase, type1, N-terminal", "go_ids": [], "go_terms": [], "name": "Ser-tRNA-synth_1_N", "pathway_ids": ["PWY-6281", "R-HSA-379716", "R-HSA-2408557"], "pathways": ["PWY-6281:t:L-selenocysteine biosynthesis II (archaea and eukaryotes)", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-2408557:r:Selenocysteine synthesis"], "type": "Domain"}, "IPR015867": {"description": "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "N-reg_PII/ATP_PRibTrfase_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015868": {"description": "Glutaminase", "go_ids": ["GO:0004359", "GO:0006541"], "go_terms": ["GO:0004359:glutaminase activity:F", "GO:0006541:L-glutamine metabolic process:P"], "name": "Glutaminase", "pathway_ids": ["PWY-5921", "R-HSA-8964539", "R-RNO-8964539", "R-MMU-8964539", "R-RNO-210500", "R-MMU-5628897", "R-RNO-5628897", "R-CEL-5628897", "R-MMU-210500", "R-CEL-210500", "R-CEL-8964539", "R-HSA-210500", "R-HSA-5628897"], "pathways": ["PWY-5921:t:glutaminyl-tRNAgln biosynthesis via transamidation", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Family"}, "IPR015870": {"description": "UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal", "go_ids": ["GO:0009245", "GO:0103117"], "go_terms": ["GO:0009245:lipid A biosynthetic process:P", "GO:0103117:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity:F"], "name": "UDP-acyl_N-AcGlcN_deAcase_N", "pathway_ids": ["PWY-8245", "PWY-8073", "PWY-8283"], "pathways": ["PWY-8245:t:lipid IVA biosynthesis (P. gingivalis)", "PWY-8073:t:lipid IVA biosynthesis (P. putida)", "PWY-8283:t:lipid IVA biosynthesis (generic)"], "type": "Homologous_superfamily"}, "IPR015871": {"description": "Transcription initiation factor IIA, gamma subunit, C-terminal", "go_ids": ["GO:0005672", "GO:0006367"], "go_terms": ["GO:0005672:transcription factor TFIIA complex:C", "GO:0006367:transcription initiation at RNA polymerase II promoter:P"], "name": "TFIIA_gsu_C", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-RNO-6807505", "R-HSA-6807505", "R-RNO-674695", "R-SCE-75953", "R-MMU-75953", "R-DME-76042", "R-RNO-73779", "R-SPO-6807505", "R-DDI-73776", "R-DME-73779", "R-RNO-9018519", "R-RNO-73776", "R-HSA-167162", "R-SCE-6807505", "R-SPO-76042", "R-DME-73776", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-DDI-9018519", "R-CEL-75953", "R-MMU-73776", "R-DDI-76042", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-CEL-73776", "R-HSA-9018519", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-CEL-6807505", "R-DME-674695", "R-DDI-73779", "R-RNO-76042", "R-SPO-9018519", "R-DME-9018519", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-HSA-167161", "R-SCE-9018519", "R-DME-6807505", "R-MMU-9018519", "R-CEL-674695", "R-SCE-674695", "R-CEL-9018519", "R-SPO-73779", "R-HSA-76042", "R-HSA-674695", "R-DDI-75953", "R-SPO-73776", "R-CEL-76042", "R-RNO-75953", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-674695:r:RNA 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Polymerase II Promoter Escape", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-69231:r:Cyclin D associated events in G1", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR015878": {"description": "S-adenosyl-L-homocysteine hydrolase, NAD binding domain", "go_ids": [], "go_terms": [], "name": "Ado_hCys_hydrolase_NAD-bd", "pathway_ids": ["R-CEL-1614635", "R-BTA-156581", "R-DDI-1614635", "R-HSA-156581", "R-DME-1614635", "R-HSA-9664323", "R-HSA-422356", "PWY-5041", "R-CEL-156581", "R-RNO-1614635", "R-HSA-5607763", "R-MMU-425381", "R-HSA-5578997", "R-DME-156581", "R-SCE-156581", "R-SCE-1614635", "R-HSA-1489509", "R-HSA-2029485", "R-HSA-1614635", "R-HSA-2408508", "R-SPO-156581", "R-HSA-112043", "R-SPO-1614635", "R-BTA-1614635", "R-RNO-156581", "R-MMU-1614635", "R-HSA-5578775", "R-DME-425381", "R-DDI-156581", "R-BTA-425381", "R-HSA-425381", "R-HSA-983695", "R-DME-5578775", "R-RNO-5578775", "R-HSA-2871809", "R-MMU-5578775", "R-MMU-156581", "R-HSA-5218921"], "pathways": ["R-CEL-1614635:r:Sulfur amino acid metabolism", "R-BTA-156581:r:Methylation", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-DME-1614635:r:Sulfur amino acid metabolism", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-422356:r:Regulation of insulin secretion", "PWY-5041:t:S-adenosyl-L-methionine salvage II", "R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-425381:r:Bicarbonate transporters", "R-HSA-5578997:r:Defective AHCY causes HMAHCHD", "R-DME-156581:r:Methylation", "R-SCE-156581:r:Methylation", "R-SCE-1614635:r:Sulfur amino acid metabolism", "R-HSA-1489509:r:DAG and IP3 signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-SPO-156581:r:Methylation", "R-HSA-112043:r:PLC beta mediated events", "R-SPO-1614635:r:Sulfur amino acid metabolism", "R-BTA-1614635:r:Sulfur amino acid metabolism", "R-RNO-156581:r:Methylation", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-5578775:r:Ion homeostasis", "R-DME-425381:r:Bicarbonate transporters", "R-DDI-156581:r:Methylation", "R-BTA-425381:r:Bicarbonate transporters", "R-HSA-425381:r:Bicarbonate transporters", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-156581:r:Methylation", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation"], "type": "Domain"}, "IPR015879": {"description": "Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain", "go_ids": ["GO:0005506", "GO:0051537"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0051537:2 iron, 2 sulfur cluster binding:F"], "name": "Ring_hydroxy_dOase_asu_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015882": {"description": "Beta-hexosaminidase, bacterial type, N-terminal", "go_ids": [], "go_terms": [], "name": "HEX_bac_N", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-7883"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-7883:t:peptidoglycan recycling II"], "type": "Domain"}, "IPR015883": {"description": "Beta-hexosaminidase, catalytic domain", "go_ids": ["GO:0005975", "GO:0004553"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "GH20_cat", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-7883", "R-DDI-9840310", "R-HSA-2024101", "R-HSA-6798695", "R-MMU-9840310", "R-DDI-6798695", "R-RNO-9840310", "R-CEL-2024101", "R-HSA-9840310", "R-CEL-6798695", "R-HSA-2022857", "R-HSA-3656234", "R-HSA-2160916", "R-MMU-2160916", "R-HSA-3656248", "R-CEL-2160916", "R-RNO-2022857", "R-MMU-2022857", "R-BTA-9840310", "R-CEL-2022857", "R-CEL-9840310", "R-RNO-2024101", "R-BTA-2160916", "R-DDI-2022857", "R-MMU-2024101", "R-MMU-6798695", "R-DDI-2160916", "R-DDI-2024101", "R-RNO-2160916", "R-BTA-2024101", "R-RNO-6798695", "R-BTA-2022857"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-7883:t:peptidoglycan recycling II", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-CEL-2024101:r:CS/DS degradation", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-2022857:r:Keratan sulfate degradation", "R-HSA-3656234:r:Defective HEXA causes GM2G1 (Hyaluronan metabolism)", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-3656248:r:Defective HEXB causes GM2G2 (Hyaluronan metabolism)", "R-CEL-2160916:r:Hyaluronan degradation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-CEL-2022857:r:Keratan sulfate degradation", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-RNO-2024101:r:CS/DS degradation", "R-BTA-2160916:r:Hyaluronan degradation", "R-DDI-2022857:r:Keratan sulfate degradation", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-2160916:r:Hyaluronan degradation", "R-DDI-2024101:r:CS/DS degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-2022857:r:Keratan sulfate degradation"], "type": "Domain"}, "IPR015886": {"description": "Formamidopyrimidine-DNA glycosylase, H2TH DNA-binding", "go_ids": ["GO:0006284", "GO:0003684", "GO:0003906", "GO:0008270", "GO:0016799"], "go_terms": ["GO:0006284:base-excision repair:P", "GO:0003684:damaged DNA binding:F", "GO:0003906:DNA-(apurinic or apyrimidinic site) endonuclease activity:F", "GO:0008270:zinc ion binding:F", "GO:0016799:hydrolase activity, hydrolyzing N-glycosyl compounds:F"], "name": "H2TH_FPG", "pathway_ids": ["R-BTA-5649702", "R-HSA-110331", "R-HSA-9629232", "R-MMU-5649702", "R-MMU-110330", "R-HSA-9616334", "R-MMU-110329", "R-HSA-110329", "R-HSA-110328", "R-HSA-9636003", "R-HSA-110330", "R-HSA-5649702", "R-MMU-110328", "R-MMU-110331", "R-BTA-110329"], "pathways": ["R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-9629232:r:Defective Base Excision Repair Associated with NEIL3", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-9616334:r:Defective Base Excision Repair Associated with NEIL1", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9636003:r:NEIL3-mediated resolution of ICLs", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-MMU-110331:r:Cleavage of the damaged purine", "R-BTA-110329:r:Cleavage of the damaged pyrimidine"], "type": "Domain"}, "IPR015888": {"description": "L-fucose isomerase, C-terminal", "go_ids": ["GO:0005737", "GO:0006004", "GO:0008736"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006004:fucose metabolic process:P", "GO:0008736:L-fucose isomerase activity:F"], "name": "Fuc_isomerase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015889": {"description": "Intradiol ring-cleavage dioxygenase, core", "go_ids": ["GO:0005506", "GO:0016702"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016702:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen:F"], "name": "Intradiol_dOase_core", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015890": {"description": "Anthranilate synthase-like domain", "go_ids": [], "go_terms": [], "name": "Anth_synth-like_dom", "pathway_ids": ["PWY-6661", "PWY-5958"], "pathways": ["PWY-6661:t:4-hydroxy-2(1H)-quinolone biosynthesis", "PWY-5958:t:acridone alkaloid biosynthesis"], "type": "Domain"}, "IPR015893": {"description": "Tetracycline transcriptional regulator, TetR-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Tet_transcr_reg_TetR-like_C", "pathway_ids": ["R-HSA-2142789", "R-SPO-2142789", "R-BTA-2142789", "R-RNO-2142789", "R-MMU-2142789", "R-DME-2142789", "R-DDI-2142789", "R-XTR-2142789"], "pathways": ["R-HSA-2142789:r:Ubiquinol biosynthesis", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-BTA-2142789:r:Ubiquinol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-XTR-2142789:r:Ubiquinol biosynthesis"], "type": "Homologous_superfamily"}, "IPR015894": {"description": "Guanylate-binding protein, N-terminal", "go_ids": ["GO:0003924", "GO:0005525"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005525:GTP binding:F"], "name": "Guanylate-bd_N", "pathway_ids": ["R-RNO-9953170", "R-HSA-168276", "R-HSA-909733", "R-HSA-877300", "R-DRE-9953170", "R-DRE-9948001", "R-HSA-9918487", "R-DRE-9968551", "R-HSA-9953170", "R-HSA-9948001", "R-HSA-9968551", "R-MMU-9953170", "R-HSA-9956593"], "pathways": ["R-RNO-9953170:r:GBP-mediated host defense", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-DRE-9953170:r:GBP-mediated host defense", "R-DRE-9948001:r:CASP4 inflammasome assembly", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-DRE-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-9953170:r:GBP-mediated host defense", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-MMU-9953170:r:GBP-mediated host defense", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense"], "type": "Domain"}, "IPR015895": {"description": "Glutamyl-tRNA reductase, N-terminal", "go_ids": ["GO:0008883", "GO:0033014", "GO:0050661"], "go_terms": ["GO:0008883:glutamyl-tRNA reductase activity:F", "GO:0033014:tetrapyrrole biosynthetic process:P", "GO:0050661:NADP binding:F"], "name": "4pyrrol_synth_GluRdtase_N", "pathway_ids": ["PWY-5188"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)"], "type": "Domain"}, "IPR015896": {"description": "Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain", "go_ids": ["GO:0008883", "GO:0033014", "GO:0050661"], "go_terms": ["GO:0008883:glutamyl-tRNA reductase activity:F", "GO:0033014:tetrapyrrole biosynthetic process:P", "GO:0050661:NADP binding:F"], "name": "4pyrrol_synth_GluRdtase_dimer", "pathway_ids": ["PWY-5188"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)"], "type": "Domain"}, "IPR015897": {"description": "CHK kinase-like", "go_ids": [], "go_terms": [], "name": "CHK_kinase-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015898": {"description": "G-protein, gamma subunit-like domain", "go_ids": ["GO:0007186"], "go_terms": ["GO:0007186:G protein-coupled receptor signaling pathway:P"], "name": "G-protein_gamma-like_dom", "pathway_ids": ["R-BTA-392170", "R-CFA-418597", "R-MMU-381771", "R-MMU-4086398", "R-CFA-8964616", "R-HSA-2485179", "R-BTA-2514859", "R-CFA-418217", "R-MMU-9009391", "R-RNO-202040", "R-BTA-400042", "R-CEL-418555", "R-BTA-8964315", "R-MMU-456926", "R-CFA-392851", "R-HSA-432040", "R-CFA-456926", "R-CFA-392170", "R-CEL-4086398", "R-HSA-392170", "R-RNO-416476", "R-CFA-4086398", "R-HSA-392851", "R-HSA-418592", "R-CFA-392451", "R-BTA-381676", "R-MMU-9634597", "R-HSA-416482", "R-HSA-418555", "R-HSA-400042", "R-BTA-418597", "R-BTA-500657", "R-MMU-420092", "R-MMU-432040", "R-RNO-456926", "R-MMU-1296041", "R-CEL-456926", "R-BTA-432040", "R-CFA-418594", "R-CFA-416476", "R-HSA-418597", "R-CEL-418597", "R-MMU-392170", "R-CFA-997272", "R-HSA-9634597", "R-CFA-9856530", "R-MMU-418597", "R-RNO-400042", "R-MMU-418594", "R-CFA-381676", "R-BTA-8964616", "R-RNO-418594", "R-MMU-8964616", "R-HSA-500657", "R-BTA-4086398", "R-MMU-392851", "R-CFA-418592", "R-HSA-4086398", "R-MMU-400042", "R-BTA-6814122", "R-CEL-2485179", "R-HSA-418217", "R-BTA-456926", "R-BTA-392851", "R-RNO-392451", "R-DME-418594", "R-BTA-9009391", "R-BTA-416482", "R-RNO-9856530", "R-HSA-9009391", "R-HSA-9717207", "R-CEL-392170", "R-RNO-6814122", "R-HSA-6814122", "R-MMU-2485179", "R-HSA-9856530", "R-RNO-432040", "R-BTA-9856530", "R-HSA-8964315", "R-MMU-418555", "R-MMU-416476", "R-MMU-8964315", "R-RNO-392170", "R-RNO-418597", "R-DME-428930", "R-HSA-381753", "R-DME-8964616", "R-BTA-420092", "R-CEL-416482", "R-BTA-202040", "R-MMU-381676", "R-MMU-202040", "R-BTA-418594", "R-BTA-1296041", "R-CFA-432040", "R-RNO-420092", "R-HSA-202040", "R-MMU-392451", "R-MMU-428930", "R-CEL-428930", "R-CEL-8964616", "R-MMU-9717207", "R-HSA-420092", "R-HSA-1296041", "R-DME-997272", "R-CFA-202040", "R-MMU-381753", "R-BTA-2485179", "R-RNO-997272", "R-HSA-2514859", "R-HSA-456926", "R-RNO-8964616", "R-DME-1296041", "R-BTA-416476", "R-MMU-418217", "R-HSA-381676", "R-BTA-418555", "R-BTA-418592", "R-MMU-997272", "R-HSA-428930", "R-CEL-997272", "R-CEL-1296041", "R-RNO-2514859", "R-CFA-500657", "R-MMU-9856530", "R-CFA-9634597", "R-CEL-400042", "R-CEL-392451", "R-CFA-400042", "R-HSA-416476", "R-CEL-416476", "R-CEL-6814122", "R-CFA-6814122", "R-CFA-420092", "R-MMU-2514859", "R-CEL-202040", "R-BTA-997272", "R-HSA-997272", "R-HSA-381771", "R-HSA-163359", "R-HSA-9660821", "R-BTA-392451", "R-DME-418597", "R-MMU-6814122", "R-MMU-500657", "R-HSA-8964616", "R-CFA-9009391", "R-CFA-428930", "R-RNO-381676", "R-CEL-418594", "R-RNO-428930", "R-RNO-1296041", "R-MMU-418592", "R-RNO-4086398", "R-HSA-418594", "R-CFA-8964315", "R-BTA-428930", "R-MMU-416482", "R-CFA-1296041", "R-BTA-418217", "R-CEL-2514859", "R-CFA-416482", "R-HSA-392451"], "pathways": ["R-BTA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-CFA-418597:r:G alpha (z) signalling events", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-MMU-4086398:r:Ca2+ pathway", "R-CFA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CFA-418217:r:G beta:gamma signalling through PLC beta", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-202040:r:G-protein activation", "R-BTA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-418555:r:G alpha (s) signalling events", "R-BTA-8964315:r:G beta:gamma signalling through BTK", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CFA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CFA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CFA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-CEL-4086398:r:Ca2+ pathway", "R-HSA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-416476:r:G alpha (q) signalling events", "R-CFA-4086398:r:Ca2+ pathway", "R-HSA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CFA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-BTA-418597:r:G alpha (z) signalling events", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-MMU-420092:r:Glucagon-type ligand receptors", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CFA-418594:r:G alpha (i) signalling events", "R-CFA-416476:r:G alpha (q) signalling events", "R-HSA-418597:r:G alpha (z) signalling events", "R-CEL-418597:r:G alpha (z) signalling events", "R-MMU-392170:r:ADP signalling through P2Y purinoceptor 12", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-9634597:r:GPER1 signaling", 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degradation", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-3214847:r:HATs acetylate histones", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DDI-1169092:r:Activation of RAS in B cells"], "type": "Homologous_superfamily"}, "IPR015917": {"description": "Peptidase C14A, caspase catalytic domain", "go_ids": ["GO:0008234"], "go_terms": ["GO:0008234:cysteine-type peptidase activity:F"], "name": "Pept_C14A", "pathway_ids": ["R-DME-198323", "R-RNO-9758274", "R-HSA-5218900", "R-HSA-168638", "R-RNO-9968551", "R-RNO-2028269", "R-MMU-198323", "R-MMU-418889", "R-HSA-9960519", "R-RNO-111465", "R-CEL-9948001", "R-BTA-9948001", "R-HSA-9693928", "R-MMU-3371378", "R-HSA-111463", "R-DME-9948011", "R-MMU-449836", "R-HSA-9956593", "R-HSA-1474228", "R-HSA-140342", "R-RNO-2562578", "R-RNO-6803207", "R-HSA-5674400", "R-MMU-9948011", "R-HSA-9660826", "R-RNO-205025", "R-HSA-9758274", "R-MMU-351906", "R-MMU-111458", "R-HSA-9948001", "R-RNO-75108", "R-HSA-69416", "R-MMU-75108", "R-DME-9948001", "R-HSA-9008059", "R-MMU-69416", "R-MMU-448706", "R-MMU-5357905", "R-DRE-9948001", "R-HSA-264870", "R-HSA-5620971", "R-RNO-351906", "R-DRE-9960519", "R-DME-2028269", "R-RNO-75153", "R-RNO-140342", "R-HSA-5357905", "R-MMU-9627069", "R-RNO-5620971", "R-DME-111458", "R-DME-69416", "R-MMU-6803207", "R-MMU-111464", "R-MMU-5218900", "R-DME-111459", "R-DME-214416", "R-HSA-9627069", "R-RNO-3371378", "R-MMU-111465", "R-MMU-5660668", "R-DME-214411", "R-DME-5357905", "R-HSA-6803207", "R-DME-5218900", "R-MMU-5675482", "R-RNO-111459", "R-RNO-5660668", "R-DME-351906", "R-MMU-75153", "R-MMU-111469", "R-RNO-69416", "R-MMU-9948001", "R-DME-6803207", "R-HSA-933543", "R-MMU-264870", "R-HSA-9948011", "R-HSA-111465", "R-HSA-205025", "R-MMU-2562578", "R-HSA-140534", "R-DME-214399", "R-CEL-198323", "R-HSA-844615", "R-BTA-9948011", "R-DRE-9960525", "R-DME-214397", "R-BTA-9960525", "R-RNO-75158", "R-CEL-9948011", "R-RNO-5357905", "R-HSA-351906", "R-DME-418889", "R-DME-352238", "R-RNO-448706", "R-HSA-75108", "R-HSA-9686347", "R-MMU-111459", "R-BTA-9960519", "R-DME-111465", "R-BTA-5620971", "R-DME-264870", "R-RNO-140534", "R-DRE-9948011", "R-HSA-111459", "R-MMU-140534", "R-HSA-5675482", "R-HSA-111458", "R-HSA-75158", "R-HSA-5357786", "R-DME-3371378", "R-MMU-6809371", "R-RNO-168638", "R-HSA-3371378", "R-MMU-75158", "R-HSA-9968551", "R-HSA-9013957", "R-HSA-844456", "R-HSA-449836", "R-HSA-111469", "R-MMU-9960525", "R-HSA-6809371", "R-HSA-9725554", "R-HSA-9960525", "R-RNO-352238", "R-HSA-418889", "R-RNO-75157", "R-DME-111469", "R-MMU-75157", "R-MMU-205025", "R-HSA-211736", "R-HSA-198323", "R-RNO-418889", "R-HSA-448706", "R-HSA-5660668", "R-MMU-9960519", "R-HSA-352238", "R-MMU-168638", "R-HSA-75153", "R-MMU-111463", "R-MMU-2028269", "R-DME-9627069", "R-DME-5675482", "R-DME-9758274", "R-HSA-111464", "R-RNO-111469", "R-MMU-352238", "R-HSA-5213460", "R-MMU-140342", "R-HSA-2562578", "R-RNO-5218900", "R-HSA-75157", "R-HSA-9692916", "R-DME-75153", "R-DME-140342", "R-RNO-264870", "R-MMU-5620971", "R-RNO-5675482", "R-MMU-9758274", "R-RNO-449836", "R-HSA-2028269", "R-HSA-844623"], "pathways": ["R-DME-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-RNO-9968551:r:Regulation of GBP-mediated host defense", "R-RNO-2028269:r:Signaling by Hippo", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-9960519:r:CASP4-mediated substrate cleavage", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-9948001:r:CASP4 inflammasome assembly", "R-BTA-9948001:r:CASP4 inflammasome assembly", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-3371378:r:Regulation by c-FLIP", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-DME-9948011:r:CASP5 inflammasome assembly", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-RNO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-9948011:r:CASP5 inflammasome assembly", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-111458:r:Formation of apoptosome", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-RNO-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-69416:r:Dimerization of procaspase-8", "R-MMU-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-DME-9948001:r:CASP4 inflammasome assembly", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-69416:r:Dimerization of procaspase-8", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-DRE-9948001:r:CASP4 inflammasome assembly", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-5620971:r:Pyroptosis", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-9960519:r:CASP4-mediated substrate cleavage", "R-DME-2028269:r:Signaling by Hippo", "R-RNO-75153:r:Apoptotic execution phase", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-RNO-5620971:r:Pyroptosis", "R-DME-111458:r:Formation of apoptosome", "R-DME-69416:r:Dimerization of procaspase-8", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-RNO-3371378:r:Regulation by c-FLIP", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-5218900:r:CASP8 activity is inhibited", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-5660668:r:CLEC7A/inflammasome pathway", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-75153:r:Apoptotic execution phase", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-69416:r:Dimerization of procaspase-8", "R-MMU-9948001:r:CASP4 inflammasome assembly", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9948011:r:CASP5 inflammasome assembly", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-205025:r:NADE modulates death signalling", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-844615:r:The AIM2 inflammasome", "R-BTA-9948011:r:CASP5 inflammasome assembly", "R-DRE-9960525:r:CASP5-mediated substrate cleavage", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-BTA-9960525:r:CASP5-mediated substrate cleavage", "R-RNO-75158:r:TRAIL signaling", "R-CEL-9948011:r:CASP5 inflammasome assembly", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-352238:r:Breakdown of the nuclear lamina", "R-RNO-448706:r:Interleukin-1 processing", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-BTA-9960519:r:CASP4-mediated substrate cleavage", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-5620971:r:Pyroptosis", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DRE-9948011:r:CASP5 inflammasome assembly", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-75158:r:TRAIL signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-DME-3371378:r:Regulation by c-FLIP", "R-MMU-6809371:r:Formation of the cornified envelope", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-3371378:r:Regulation by c-FLIP", "R-MMU-75158:r:TRAIL signaling", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-RNO-352238:r:Breakdown of the nuclear lamina", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-RNO-75157:r:FasL/ CD95L signaling", "R-DME-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-75157:r:FasL/ CD95L signaling", "R-MMU-205025:r:NADE modulates death signalling", "R-HSA-211736:r:Stimulation of the cell death response by PAK-2p34", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-448706:r:Interleukin-1 processing", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-HSA-352238:r:Breakdown of the nuclear lamina", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-75153:r:Apoptotic execution phase", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-MMU-2028269:r:Signaling by Hippo", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-352238:r:Breakdown of the nuclear lamina", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-RNO-5218900:r:CASP8 activity is inhibited", "R-HSA-75157:r:FasL/ CD95L signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DME-75153:r:Apoptotic execution phase", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-5620971:r:Pyroptosis", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR015919": {"description": "Cadherin-like superfamily", "go_ids": ["GO:0005509", "GO:0016020"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0016020:membrane:C"], "name": "Cadherin-like_sf", "pathway_ids": ["R-DRE-9768727", "R-HSA-3000178", "R-RNO-1474228", "R-HSA-9010553", "R-HSA-8932504", "R-MMU-9013408", "R-RNO-525793", "R-HSA-9764562", "R-HSA-418990", "R-DME-390150", "R-HSA-5218920", "R-HSA-8853659", "R-HSA-9662360", "R-DME-350411", "R-CFA-8932506", "R-CFA-418990", "R-RNO-6805567", "R-MMU-5673001", "R-DME-390023", "R-CFA-8932505", "R-MMU-8932506", "R-HSA-1474228", "R-CFA-351906", "R-DRE-9764561", "R-MMU-9939291", "R-HSA-5083633", "R-HSA-3000171", "R-DME-114608", "R-MMU-351906", "R-DME-6809371", "R-HSA-9696264", "R-MMU-9013423", "R-DRE-9766229", "R-DRE-381426", "R-CFA-9010553", "R-MMU-216083", "R-HSA-9013026", "R-HSA-9762292", "R-HSA-9939291", "R-MMU-9696264", "R-HSA-5083629", "R-HSA-9768727", "R-MMU-9768727", "R-MMU-9766229", "R-HSA-9768919", "R-SSC-9696270", "R-SSC-6798695", "R-RNO-216083", "R-DRE-1474228", "R-RNO-351906", "R-HSA-9013423", "R-HSA-114608", "R-DRE-9696264", "R-SSC-5218920", "R-GGA-381426", "R-HSA-6805567", "R-DRE-8957275", "R-CEL-9013423", "R-MMU-5626467", "R-HSA-9696270", "R-DME-6798695", "R-RNO-5626467", "R-DRE-6809371", "R-HSA-9913351", "R-DME-350480", "R-CFA-9764561", "R-DME-351906", "R-SSC-6805567", "R-MMU-8932504", "R-HSA-9856649", "R-MMU-525793", "R-HSA-9856530", "R-HSA-9833576", "R-MMU-6805567", "R-HSA-6798695", "R-CEL-6798695", "R-HSA-9766229", "R-MMU-9013404", "R-HSA-351906", "R-HSA-9927418", "R-MMU-8957275", "R-DME-350376", "R-HSA-9764561", "R-DRE-5626467", "R-DRE-6798695", "R-HSA-9823730", "R-MMU-381426", "R-GGA-8957275", "R-HSA-9926550", "R-HSA-9759811", "R-DRE-418990", "R-HSA-9013408", "R-RNO-9768727", "R-DRE-9696270", "R-RNO-5673001", "R-HSA-381426", "R-MMU-1474228", "R-BTA-418990", "R-HSA-8932505", "R-SSC-418990", "R-DRE-5218920", "R-DME-8980692", "R-RNO-8853659", "R-HSA-9830364", "R-DRE-6805567", "R-MMU-8853659", "R-SSC-351906", "R-CFA-6805567", "R-GGA-525793", "R-MMU-9762292", "R-HSA-5673001", "R-HSA-9013404", "R-RNO-381426", "R-HSA-8980692", "R-MMU-6809371", "R-MMU-9913351", "R-CFA-1474228", "R-DRE-351906", "R-HSA-198933", "R-MMU-6798695", "R-HSA-5083628", "R-CEL-6809371", "R-DME-350379", "R-SSC-9696264", "R-HSA-6809371", "R-HSA-5626467", "R-RNO-418990", "R-HSA-9619665", "R-MMU-9010553", "R-DME-350368", "R-CFA-216083", "R-CFA-9768727", "R-HSA-8932506", "R-MMU-9764561", "R-RNO-8957275", "R-CFA-8932504", "R-HSA-9938206", "R-HSA-525793", "R-DME-450728", "R-CFA-6809371", "R-CFA-9766229", "R-MMU-8932505", "R-RNO-6809371", "R-RNO-9764561", "R-HSA-216083", "R-GGA-418990", "R-MMU-5218920", "R-CFA-9939291", "R-HSA-9662361", "R-HSA-9927432", "R-CFA-9913351", "R-HSA-9764302", "R-MMU-418990", "R-HSA-8876493", "R-HSA-9830674", "R-SSC-6809371", "R-RNO-9766229", "R-HSA-8957275", "R-MMU-9696270", "R-DRE-525793", "R-DME-9013423"], "pathways": ["R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-525793:r:Myogenesis", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-418990:r:Adherens junctions interactions", "R-DME-390150:r:DS 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"R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-6809371:r:Formation of the cornified envelope", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-DRE-9766229:r:Degradation of CDH1", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CFA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9762292:r:Regulation of CDH11 function", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-5083629:r:Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-9768919:r:NPAS4 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uptake and transport", "R-HSA-389542:r:NADPH regeneration", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-389542:r:NADPH regeneration", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Homologous_superfamily"}, "IPR015932": {"description": "Aconitase, domain 2", "go_ids": [], "go_terms": [], "name": "Aconitase_dom2", "pathway_ids": ["R-DDI-9837999", "R-HSA-9854311", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-9854311", "R-SPO-9854311", "R-BTA-71403", "R-RNO-9837999", "R-RNO-9854311", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-CEL-9854311", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-71403", "R-SCE-9837999", "R-HSA-1268020", "R-MMU-71403", "R-DDI-9854311", "R-DDI-71403", "R-HSA-9837999", "R-RNO-71403", "R-HSA-71403", "R-SCE-9854311"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Homologous_superfamily"}, "IPR015933": {"description": "Aconitase B, HEAT-like domain", "go_ids": ["GO:0003994", "GO:0006099"], "go_terms": ["GO:0003994:aconitate hydratase activity:F", "GO:0006099:tricarboxylic acid cycle:P"], "name": "Aconitase_B_HEAT-like_dom", "pathway_ids": ["PWY-5747"], "pathways": ["PWY-5747:t:2-methylcitrate cycle II"], "type": "Domain"}, "IPR015938": {"description": "Glycine N-acyltransferase, N-terminal", "go_ids": ["GO:0047961", "GO:0005739"], "go_terms": ["GO:0047961:glycine N-acyltransferase activity:F", "GO:0005739:mitochondrion:C"], "name": "Glycine_N-acyltransferase_N", "pathway_ids": ["R-MMU-177135", "R-HSA-177128", "R-RNO-177135", "R-HSA-9749641", "R-MMU-177128", "R-RNO-9749641", "R-MMU-9749641", "R-HSA-177135", "R-RNO-177128"], "pathways": ["R-MMU-177135:r:Conjugation of benzoate with glycine", "R-HSA-177128:r:Conjugation of salicylate with glycine", "R-RNO-177135:r:Conjugation of benzoate with glycine", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-177128:r:Conjugation of salicylate with glycine", "R-RNO-9749641:r:Aspirin ADME", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-177135:r:Conjugation of benzoate with glycine", "R-RNO-177128:r:Conjugation of salicylate with glycine"], "type": "Domain"}, "IPR015939": {"description": "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Fum_Rdtase/Succ_DH_flav-like_C", "pathway_ids": ["R-HSA-9854311", "R-SPO-9854311", "R-DRE-9854311", "R-GGA-372987", "R-SSC-9854311", "R-DRE-71403", "R-HSA-611105", "R-RNO-9854311", "R-DME-9854311", "R-SSC-71403", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-CEL-9854311", "R-MMU-71403", "R-SCE-71403", "R-XTR-9854311", "R-DME-71403", "R-DDI-9854311", "R-DDI-71403", "R-RNO-71403", "R-XTR-71403", "R-HSA-71403", "R-SCE-9854311"], "pathways": ["R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Domain"}, "IPR015940": {"description": "Ubiquitin-associated domain", "go_ids": [], "go_terms": [], "name": "UBA", "pathway_ids": ["R-XTR-532668", "R-MMU-426496", "R-HSA-8856828", "R-SCE-416482", "R-HSA-8948700", "R-MMU-5205685", "R-MMU-1295596", "R-MMU-8951664", "R-SPO-5696395", "R-MMU-5696395", "R-HSA-8866652", "R-RNO-5689877", "R-HSA-9649948", "R-SPO-8856825", "R-SPO-200425", "R-RNO-205043", "R-HSA-9759811", "R-SPO-163680", "R-MMU-5654732", "R-SCE-9013420", "R-HSA-174490", "R-HSA-5205685", "R-CEL-9856649", "R-HSA-9018519", "R-HSA-2173789", "R-HSA-9610379", "R-RNO-5205685", "R-HSA-209560", "R-MMU-209543", "R-DDI-8948751", "R-RNO-209560", "R-HSA-5654732", "R-HSA-9755511", "R-HSA-5357786", "R-DME-9755511", "R-SCE-9013148", "R-HSA-9768778", "R-BTA-8866652", "R-RNO-532668", "R-SCE-8856825", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5654733", "R-RNO-983168", "R-SPO-1632852", "R-DDI-8866652", "R-HSA-8853884", "R-MMU-8856825", "R-HSA-209543", "R-HSA-2559585", "R-HSA-936440", "R-MMU-9755511", "R-HSA-5628897", "R-HSA-1912408", "R-SCE-9013406", "R-HSA-6802946", "R-HSA-1236382", "R-HSA-9759194", "R-BTA-5696395", "R-HSA-5620912", 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"R-GGA-8948751", "R-HSA-205043", "R-RNO-5696395", "R-SPO-5696394", "R-MMU-5673000", "R-BTA-5693565", "R-RNO-5675221", "R-SPO-9013148", "R-CEL-5674135", "R-SCE-193648", "R-HSA-162588", "R-HSA-5637810", "R-HSA-8934593", "R-RNO-209543", "R-RNO-5696394", "R-HSA-1433559", "R-DDI-5674135", "R-HSA-1295596", "R-DDI-5696394", "R-HSA-5696395", "R-MMU-5357905", "R-HSA-5696394", "R-HSA-549127", "R-HSA-8986944", "R-HSA-426496", "R-BTA-532668", "R-CEL-8856825", "R-DME-426496", "R-HSA-9680350", "R-RNO-6798695", "R-MMU-5675221", "R-HSA-9656223", "R-HSA-9664873", "R-DME-983168", "R-MMU-5674135", "R-DDI-5696395", "R-HSA-1059683", "R-DME-5578749", "R-MMU-5357956", "R-DRE-532668", "R-DME-8866652", "R-MMU-9664873", "R-SPO-9013406", "R-MMU-5693565", "R-HSA-5357905", "R-MMU-532668", "R-RNO-5674135", "R-HSA-4086398", "R-HSA-9615710", "R-HSA-5689877", "R-MMU-205043", "R-DDI-5689880", "R-HSA-9706369", "R-MMU-912631", "R-MMU-2173789", "R-RNO-9664873", "R-HSA-9839394", "R-MMU-209560", "R-RNO-9856649", "R-SPO-5628897", "R-BTA-5696394", "R-HSA-5654726", "R-RNO-9755511", "R-HSA-8943723", "R-MMU-9706369", "R-HSA-6807004", "R-DDI-5675221", "R-GGA-5689880", "R-MMU-5654726", "R-HSA-917729", "R-HSA-9725371", "R-HSA-5357956", "R-HSA-8856825", "R-MMU-5654727", "R-HSA-9909620", "R-MMU-6807004", "R-HSA-9856649", "R-HSA-9725370", "R-HSA-8875360", "R-HSA-8849469", "R-BTA-983168", "R-MMU-182971", "R-MMU-1433559", "R-MMU-9856649", "R-HSA-6798695", "R-HSA-5674135", "R-RNO-9020702"], "pathways": ["R-XTR-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-MMU-8951664:r:Neddylation", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", 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"R-MMU-350054", "R-DME-1257604", "R-SPO-6811434", "R-HSA-418597", "R-CEL-418597", "R-CFA-416476", "R-HSA-5696395", "R-HSA-174048", "R-BTA-8866654", "R-CEL-72649", "R-DME-416482", "R-DME-72702", "R-SSC-9734091", "R-MMU-5663220", "R-HSA-5685942", "R-BTA-5357956", "R-GGA-8951664", "R-MMU-418597", "R-HSA-3371497", "R-BTA-380972", "R-DRE-3108214", "R-BTA-6807878", "R-BTA-6781823", "R-MMU-8874081", "R-DRE-73856", "R-HSA-5357905", "R-DME-209396", "R-HSA-165054", "R-HSA-2559584", "R-BTA-174184", "R-BTA-6814122", "R-HSA-167172", "R-BTA-2132295", "R-SSC-8851907", "R-SSC-9648025", "R-HSA-5693568", "R-MMU-176408", "R-HSA-5610780", "R-RNO-68877", "R-HSA-418217", "R-BTA-3232142", "R-DME-9646399", "R-CEL-381070", "R-MMU-5607761", "R-CEL-5689880", "R-HSA-201722", "R-HSA-975957", "R-RNO-5696400", "R-SSC-8865999", "R-MMU-6807004", "R-HSA-5663220", "R-CFA-381753", "R-HSA-9856530", "R-RNO-3769402", "R-MMU-525793", "R-HSA-2426168", "R-DME-9013420", "R-GGA-380270", "R-HSA-1989781", "R-MMU-204005", "R-HSA-9700645", "R-CEL-3301854", "R-BTA-179409", "R-RNO-418597", "R-DME-8951664", "R-BTA-141430", "R-SPO-6807505", "R-HSA-9766229", "R-RNO-73863", "R-DME-9930044", "R-HSA-3928662", "R-MMU-202040", "R-CEL-159230", "R-RNO-9013424", "R-DDI-2559582", "R-HSA-9707564", "R-MMU-3247509", "R-MMU-5628897", "R-DME-997272", "R-DME-6804758", "R-HSA-429958", "R-HSA-9825892", "R-DME-9909649", "R-HSA-9610379", "R-MMU-5684264", "R-DME-8980692", "R-BTA-9909649", "R-HSA-456926", "R-HSA-6784531", "R-DRE-1538133", "R-CEL-4641265", "R-HSA-2219530", "R-DDI-380972", "R-RNO-9696273", "R-MMU-450520", "R-CFA-6791226", "R-DRE-983170", "R-RNO-429947", "R-DRE-5684264", "R-SPO-4570464", "R-HSA-1362277", "R-MMU-2871837", "R-MMU-141430", "R-HSA-6791226", "R-BTA-418592", "R-MMU-997272", "R-CEL-8953750", "R-HSA-9860927", "R-MMU-6782210", "R-RNO-983168", "R-HSA-5617472", "R-CFA-500657", "R-DDI-72702", "R-MMU-69231", "R-MMU-73762", "R-DME-1169091", "R-RNO-4641265", "R-HSA-3769402", "R-HSA-69205", "R-DDI-69273", "R-XTR-380270", "R-CEL-201722", "R-MMU-212300", "R-HSA-174184", "R-DME-9860927", "R-HSA-3214858", "R-HSA-5628897", "R-MMU-174048", "R-MMU-4615885", "R-HSA-9909505", "R-RNO-1655829", "R-DME-209214", "R-HSA-167162", "R-DDI-6814122", "R-RNO-3214815", "R-CEL-399955", "R-CEL-8943724", "R-HSA-9845323", "R-SPO-983168", "R-HSA-9920951", "R-BTA-5696395", "R-BTA-168638", "R-HSA-163359", "R-SSC-141444", "R-HSA-9734091", "R-GGA-2173788", "R-DRE-5689880", "R-DRE-156827", "R-HSA-9013420", "R-RNO-6807878", "R-HSA-4641265", "R-SPO-72695", "R-DME-9707564", "R-XTR-156827", "R-MMU-73863", "R-XTR-75955", "R-MMU-5685942", "R-CEL-418594", "R-DME-159230", "R-MMU-9013026", "R-SSC-8875791", "R-DRE-6791226", "R-HSA-9022699", "R-DDI-389357", "R-HSA-5358493", "R-BTA-141444", "R-CEL-76042", "R-SCE-69273", "R-MMU-6811438", "R-MMU-75953", "R-HSA-2559580", "R-CFA-418597", "R-MMU-6811558", "R-CEL-159227", "R-MMU-4570464", "R-HSA-2485179", "R-RNO-110314", "R-HSA-170822", "R-RNO-8866654", "R-RNO-416550", "R-RNO-5218920", "R-HSA-72695", "R-RNO-399954", "R-DRE-9930044", "R-DRE-75955", "R-CEL-110314", "R-HSA-9844594", "R-BTA-2500257", "R-DME-5676590", "R-GGA-5663220", "R-DME-400206", "R-DRE-416550", "R-HSA-392170", "R-XTR-8943724", "R-MMU-6811434", "R-BTA-75955", "R-DDI-174084", "R-SSC-176408", "R-HSA-5607761", "R-HSA-1170546", "R-SPO-159236", "R-DRE-77595", "R-HSA-5674400", "R-MMU-4641265", "R-HSA-9022537", "R-CEL-2995383", "R-BTA-72702", "R-BTA-3214847", "R-DRE-380320", "R-RNO-5696395", "R-CEL-5620924", "R-DME-1538133", "R-BTA-1632852", "R-DME-6804756", "R-RNO-456926", "R-HSA-3232142", "R-HSA-8866654", "R-DME-416572", "R-RNO-176408", "R-CEL-6782135", "R-RNO-9627069", "R-HSA-389357", "R-DME-416700", "R-SPO-8951664", "R-BTA-6782210", "R-RNO-5620924", "R-MMU-9013418", "R-SPO-73776", "R-MMU-9766229", "R-XTR-9772755", "R-HSA-8865999", "R-HSA-174154", "R-SCE-429947", "R-DME-350054", "R-MMU-3232142", "R-CFA-9856530", "R-HSA-9944997", "R-DRE-5626978", "R-MMU-77595", "R-SPO-76061", "R-HSA-156827", "R-CEL-381042", "R-RNO-400042", "R-CEL-141430", "R-CFA-381676", "R-MMU-8964616", "R-DRE-983168", "R-BTA-4086398", "R-DDI-176409", "R-DRE-6811434", "R-MMU-2132295", "R-MMU-392851", "R-RNO-3928662", "R-BTA-380320", "R-RNO-159236", "R-MMU-400042", "R-HSA-9762114", "R-SCE-156827", "R-DME-6811440", "R-HSA-9770562", "R-SPO-4551638", "R-HSA-9707616", "R-RNO-159227", "R-RNO-174113", "R-DDI-5675221", "R-DME-6811434", "R-DME-9833482", "R-HSA-5173214", "R-CEL-2565942", "R-DME-430039", "R-HSA-427389", "R-HSA-6814122", "R-HSA-180746", "R-MMU-168138", "R-HSA-2173788", "R-DME-975957", "R-BTA-5357905", "R-DME-5689880", "R-DDI-1266695", "R-XTR-4615885", "R-GGA-1632852", "R-DRE-5674135", "R-RNO-674695", "R-HSA-9920588", "R-DME-76042", "R-DME-3371497", "R-HSA-8856828", "R-DME-428930", "R-DRE-9639288", "R-DME-4085377", "R-DRE-141444", "R-SPO-1660516", "R-MMU-2565942", "R-BTA-176409", "R-HSA-5694530", "R-MMU-111459", "R-DDI-6804757", "R-MMU-5696395", "R-BTA-418594", "R-DRE-6804758", "R-DRE-6798695", "R-RNO-5626978", "R-CEL-428930", "R-HSA-6804757", "R-MMU-399954", "R-RNO-8865999", "R-DRE-381771", "R-HSA-212436", "R-CEL-525793", "R-RNO-6782210", "R-DDI-429958", "R-BTA-3301854", "R-SPO-2559582", "R-CEL-9860927", "R-MMU-141444", "R-DRE-5218920", "R-DRE-5620922", "R-SCE-141430", "R-DDI-6781823", "R-BTA-3371571", "R-SPO-5218920", "R-HSA-450520", "R-HSA-8876198", "R-SPO-179409", "R-DRE-5696394", "R-MMU-159236", "R-RNO-6791226", "R-CEL-6781823", "R-SPO-9770562", "R-RNO-6804758", "R-MMU-8876198", "R-DDI-141430", "R-SCE-2029482", "R-HSA-400206", "R-MMU-6798695", "R-RNO-9639288", "R-MMU-416700", "R-MMU-114608", "R-HSA-416550", "R-SPO-72702", "R-HSA-1660517", "R-HSA-3108214", "R-CEL-392451", "R-RNO-606279", "R-DDI-1660499", "R-XTR-2467813", "R-MMU-6807878", "R-SPO-114608", "R-RNO-2029482", "R-RNO-5668599", "R-HSA-2871837", "R-DRE-2132295", "R-RNO-1660516", "R-DDI-9772755", "R-DME-166208", "R-DRE-5676590", "R-HSA-432722", "R-SCE-3371571", "R-HSA-9660821", "R-HSA-9931509", "R-HSA-380972", "R-HSA-8875791", "R-BTA-429958", "R-HSA-2500257", "R-SCE-6807878", "R-RNO-8854518", "R-XTR-429958", "R-DME-212300", "R-DME-9627069", "R-DRE-2500257", "R-DME-4551638", "R-HSA-1660514", "R-HSA-9754678", "R-RNO-428930", "R-DME-201722", "R-GGA-5696395", "R-XTR-8953750", "R-RNO-4551638", "R-DRE-72649", "R-DRE-9013148", "R-MMU-6806942", "R-XTR-983168", "R-MMU-416482", "R-BTA-159231", "R-SPO-6782135", "R-HSA-9664422", "R-SSC-8875656", "R-CFA-416482", "R-SPO-141430", "R-DME-69273", "R-HSA-180910", "R-HSA-5689880", "R-GGA-110314", "R-HSA-427413", "R-SPO-389357", "R-HSA-73856", "R-XTR-159236", "R-GGA-2565942", "R-DDI-114608", "R-HSA-9639288", "R-SCE-6807505", "R-SPO-76042", "R-MMU-4551638", "R-MMU-456926", "R-BTA-5663213", "R-SCE-6804757", "R-MMU-9013420", "R-MMU-5663213", "R-RNO-5696394", "R-SPO-5668599", "R-HSA-76061", "R-MMU-1655829", "R-MMU-5673001", "R-MMU-68867", "R-HSA-392851", "R-CFA-177929", "R-MMU-72163", "R-BTA-6782135", "R-DME-209461", "R-DRE-69601", "R-RNO-5628897", "R-HSA-141444", "R-DRE-420092", "R-HSA-9764725", "R-BTA-2173788", "R-GGA-5620912", "R-DRE-3371453", "R-HSA-72702", "R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-SPO-110314", "R-CEL-5696395", "R-HSA-5696394", "R-RNO-9696264", "R-DME-69601", "R-DME-1632852", "R-MMU-73772", "R-HSA-2644606", "R-MMU-69273", "R-MMU-9860927", "R-MMU-416550", "R-RNO-8851907", "R-HSA-8857538", "R-SSC-8875513", "R-DME-983168", "R-HSA-416572", "R-HSA-2467813", "R-HSA-6781827", "R-MMU-380972", "R-HSA-9772755", "R-MMU-8980692", "R-DDI-6791226", "R-RNO-77595", "R-DRE-191859", "R-HSA-9861718", "R-DRE-9770562", "R-HSA-8851907", "R-HSA-6782315", "R-HSA-1538133", "R-MMU-9772755", "R-DME-8953750", "R-SPO-9013420", "R-BTA-5696400", "R-DDI-5668599", "R-BTA-1538133", "R-SCE-72695", "R-MMU-72695", "R-BTA-8856828", "R-GGA-6783310", "R-DRE-9861718", "R-DME-209360", "R-DDI-1632852", "R-DME-5357905", "R-HSA-156711", "R-SPO-1660514", "R-DME-72689", "R-BTA-392851", "R-RNO-72702", "R-DME-418594", "R-HSA-9760173", "R-HSA-380270", "R-DDI-166208", "R-MMU-1169091", "R-HSA-72649", "R-MMU-8943724", "R-RNO-9856530", "R-HSA-9909649", "R-MMU-72187", "R-RNO-9770562", "R-XTR-8866654", "R-HSA-5696400", "R-XTR-2559580", "R-HSA-8875656", "R-HSA-112314", "R-MMU-8953750", "R-DME-209155", "R-RNO-2995383", "R-DRE-399954", "R-MMU-5607764", "R-DRE-381753", "R-DME-69231", "R-HSA-72187", "R-DME-8964616", "R-HSA-5676590", "R-BTA-420092", "R-BTA-72689", "R-SSC-6811558", "R-HSA-380320", "R-HSA-141430", "R-RNO-159230", "R-RNO-420092", "R-BTA-1296041", "R-MMU-9717207", "R-MMU-428930", "R-BTA-72695", "R-SCE-9013420", "R-MMU-1660514", "R-BTA-381042", "R-MMU-5693568", "R-DDI-1660517", "R-HSA-4551638", "R-HSA-176408", "R-MMU-5620924", "R-SCE-9856530", "R-MMU-76042", "R-RNO-389357", "R-BTA-2485179", "R-CEL-6807505", "R-BTA-3371453", "R-CEL-9833482", "R-RNO-381042", "R-MMU-6811436", "R-BTA-416476", "R-DME-3769402", "R-CEL-156827", "R-HSA-9013149", "R-HSA-1169091", "R-HSA-8980692", "R-BTA-418555", "R-SCE-674695", "R-CEL-1296041", "R-SPO-429947", "R-GGA-8854518", "R-HSA-110314", "R-DRE-5628897", "R-HSA-8853884", "R-SPO-176408", "R-RNO-3371453", "R-RNO-8943724", "R-RNO-201722", "R-DME-77595", "R-HSA-76066", "R-CEL-1632852", "R-CEL-416700", "R-DDI-9770562", "R-CEL-73856", "R-HSA-416476", "R-SPO-3214847", "R-CFA-6814122", "R-MMU-69601", "R-SCE-975957", "R-HSA-3214841", "R-DME-5607761", "R-SPO-9013409", "R-SCE-1257604", "R-HSA-381771", "R-HSA-9029569", "R-MMU-9648025", "R-HSA-5620912", "R-DRE-9909649", "R-HSA-5607764", "R-HSA-141405", "R-DDI-381070", "R-HSA-193648", "R-MMU-3769402", "R-SSC-6807004", "R-DRE-111459", "R-XTR-201722", "R-HSA-8964616", "R-RNO-6782135", "R-CEL-6811436", "R-XTR-3301854", "R-XTR-68877", "R-DME-4641265", "R-RNO-204005", "R-SCE-9907900", "R-BTA-380270", "R-RNO-170822", "R-DRE-3214841", "R-DME-9841922", "R-MMU-166208", "R-RNO-5357956", "R-CFA-1296041", "R-DRE-3214858", "R-HSA-176417"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-XTR-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8951664:r:Neddylation", "R-MMU-1632852:r:Macroautophagy", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-XTR-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CFA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CEL-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-165159:r:MTOR signalling", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9634597:r:GPER1 signaling", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-418597:r:G alpha (z) signalling events", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-XTR-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-165159:r:MTOR signalling", "R-SSC-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-429947:r:Deadenylation of mRNA", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-HSA-8852405:r:Signaling by MST1", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-69231:r:Cyclin D associated events in G1", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-GGA-5689880:r:Ub-specific processing proteases", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-418555:r:G alpha (s) signalling events", "R-CEL-8951664:r:Neddylation", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-8875791:r:MET activates STAT3", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-202040:r:G-protein activation", "R-DDI-8951664:r:Neddylation", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SPO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-XTR-5689880:r:Ub-specific processing proteases", "R-SSC-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-RNO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-418594:r:G alpha (i) signalling events", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-209421:r:Transcription activation by ARM", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-176417:r:Phosphorylation of Emi1", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CFA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DME-525793:r:Myogenesis", "R-CEL-416476:r:G alpha (q) signalling events", "R-RNO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-72649:r:Translation initiation complex formation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-GGA-353303:r:Nucleotide Excision Repair", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9013424:r:RHOV GTPase cycle", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-HSA-8851805:r:MET activates RAS signaling", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-428930:r:Thromboxane signalling through TP receptor", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-3214815:r:HDACs deacetylate histones", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-SCE-72649:r:Translation initiation complex formation", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-165159:r:MTOR signalling", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "R-XTR-5620924:r:Intraflagellar transport", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-1266695:r:Interleukin-7 signaling", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-3214815:r:HDACs deacetylate histones", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CFA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-XTR-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-166208:r:mTORC1-mediated signalling", "R-CFA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-DRE-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DRE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-CEL-69231:r:Cyclin D associated events in G1", "R-DDI-9033241:r:Peroxisomal protein import", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-BTA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-8851805:r:MET activates RAS signaling", "R-RNO-8951664:r:Neddylation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SSC-6806942:r:MET Receptor Activation", "R-DRE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DME-429947:r:Deadenylation of mRNA", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-XTR-3214847:r:HATs acetylate histones", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-4085377:r:SUMOylation of SUMOylation proteins", "R-SSC-8874081:r:MET activates PTK2 signaling", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-68877:r:Mitotic Prometaphase", "R-DME-3214858:r:RMTs methylate histone arginines", "R-CFA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-MMU-191859:r:snRNP Assembly", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-SSC-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2485179:r:Activation of the phototransduction cascade", "R-RNO-5694530:r:Cargo concentration in the ER", "R-RNO-416700:r:Other semaphorin interactions", "R-BTA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-8875791:r:MET activates STAT3", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-GGA-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-XTR-3214815:r:HDACs deacetylate histones", "R-RNO-3214847:r:HATs acetylate histones", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-9733709:r:Cardiogenesis", "R-DME-5696400:r:Dual Incision in GG-NER", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-RNO-9646399:r:Aggrephagy", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-3214815:r:HDACs deacetylate histones", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-DRE-8943724:r:Regulation of PTEN gene transcription", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-191859:r:snRNP Assembly", "R-SPO-9696273:r:RND1 GTPase cycle", "R-DRE-3214847:r:HATs acetylate histones", "R-CFA-202040:r:G-protein activation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-381753:r:Olfactory Signaling Pathway", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-SCE-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-CEL-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DME-381042:r:PERK regulates gene expression", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SSC-5689880:r:Ub-specific processing proteases", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-SCE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-418597:r:G alpha (z) signalling events", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-SPO-72649:r:Translation initiation complex formation", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-3214847:r:HATs acetylate histones", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-CEL-418555:r:G alpha (s) signalling events", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-4086398:r:Ca2+ pathway", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-CFA-4086398:r:Ca2+ pathway", "R-MMU-9930044:r:Nuclear RNA decay", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-111458:r:Formation of apoptosome", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DRE-3371571:r:HSF1-dependent transactivation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-392170:r:ADP signalling through P2Y purinoceptor 12", "R-HSA-194138:r:Signaling by VEGF", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-BTA-381753:r:Olfactory Signaling Pathway", "R-BTA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-191859:r:snRNP Assembly", "R-DRE-2485179:r:Activation of the phototransduction cascade", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-RNO-418594:r:G alpha (i) signalling events", "R-XTR-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9907900:r:Proteasome assembly", "R-BTA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-418594:r:G alpha (i) signalling events", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DME-9037629:r:Lewis blood group biosynthesis", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-3214847:r:HATs acetylate histones", "R-XTR-191859:r:snRNP Assembly", "R-DRE-9646399:r:Aggrephagy", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-166208:r:mTORC1-mediated signalling", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-GGA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-9013106:r:RHOC GTPase cycle", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-392170:r:ADP signalling through P2Y purinoceptor 12", "R-MMU-5694530:r:Cargo concentration in the ER", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-111458:r:Formation of apoptosome", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-202040:r:G-protein activation", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-DRE-9013407:r:RHOH GTPase cycle", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-SPO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-420092:r:Glucagon-type ligand receptors", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-XTR-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-SSC-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DRE-165159:r:MTOR signalling", "R-BTA-177929:r:Signaling by EGFR", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-9930044:r:Nuclear RNA decay", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-977225:r:Amyloid fiber formation", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-109704:r:PI3K Cascade", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-525793:r:Myogenesis", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DME-450728:r:Inhibition of actin polymerization", "R-BTA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-209190:r:Phosphorylation of CI", "R-SSC-3232142:r:SUMOylation of ubiquitinylation proteins", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-RNO-4086398:r:Ca2+ pathway", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-202040:r:G-protein activation", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-4086398:r:Ca2+ pathway", "R-CFA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-191859:r:snRNP Assembly", "R-SCE-114608:r:Platelet degranulation", "R-RNO-5610787:r:Hedgehog 'off' state", "R-HSA-381042:r:PERK regulates gene expression", "R-DRE-111458:r:Formation of apoptosome", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-8964315:r:G beta:gamma signalling through BTK", "R-DDI-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5673000:r:RAF activation", "R-DME-5610787:r:Hedgehog 'off' state", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-6806942:r:MET Receptor Activation", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-191859:r:snRNP Assembly", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-XTR-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DDI-165159:r:MTOR signalling", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-983189:r:Kinesins", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-9907900:r:Proteasome assembly", "R-CEL-5610787:r:Hedgehog 'off' state", "R-DME-111458:r:Formation of apoptosome", "R-SSC-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-DRE-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-XTR-1538133:r:G0 and Early G1", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-109704:r:PI3K Cascade", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-176417:r:Phosphorylation of Emi1", "R-SSC-8875555:r:MET activates RAP1 and RAC1", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-XTR-8951664:r:Neddylation", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6807004:r:Negative regulation of MET activity", "R-SPO-9033241:r:Peroxisomal protein import", "R-DME-3214847:r:HATs acetylate histones", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-CEL-392170:r:ADP signalling through P2Y purinoceptor 12", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SSC-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-XTR-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-983189:r:Kinesins", "R-SPO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-8951664:r:Neddylation", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-DDI-9646399:r:Aggrephagy", "R-SSC-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-DRE-3214815:r:HDACs deacetylate histones", "R-SPO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-381042:r:PERK regulates gene expression", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-176417:r:Phosphorylation of Emi1", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SSC-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-209441:r:WG ligand not bound to FZ receptors", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-1296041:r:Activation of G protein gated Potassium channels", "R-MMU-674695:r:RNA 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"R-SSC-68877:r:Mitotic Prometaphase", "R-BTA-4570464:r:SUMOylation of RNA binding proteins", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-CFA-420092:r:Glucagon-type ligand receptors", "R-CEL-1538133:r:G0 and Early G1", "R-SCE-381070:r:IRE1alpha activates chaperones", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9833110:r:RSV-host interactions", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-CEL-3214847:r:HATs acetylate histones", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-GGA-429947:r:Deadenylation of mRNA", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-392170:r:ADP signalling through P2Y purinoceptor 12", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-CFA-8964315:r:G beta:gamma signalling through BTK", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-8851805:r:MET activates RAS signaling", "R-DRE-416476:r:G alpha (q) signalling events", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-HSA-163615:r:PKA activation", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-418597:r:G alpha (z) signalling events", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CFA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-5610787:r:Hedgehog 'off' state", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-XTR-5610787:r:Hedgehog 'off' state", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SSC-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-SCE-9696273:r:RND1 GTPase cycle", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3247509:r:Chromatin modifying enzymes", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9710421:r:Defective pyroptosis", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-1632852:r:Macroautophagy", "R-CFA-418594:r:G alpha (i) signalling events", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SSC-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-9648025:r:EML4 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"R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-114608:r:Platelet degranulation", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-381070:r:IRE1alpha activates chaperones", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DDI-5689880:r:Ub-specific processing proteases", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-BTA-4615885:r:SUMOylation of DNA replication proteins", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SPO-381070:r:IRE1alpha activates chaperones", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-381070:r:IRE1alpha activates chaperones", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-3214847:r:HATs acetylate histones", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9696273:r:RND1 GTPase cycle", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-9907900:r:Proteasome assembly", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-CFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DDI-3247509:r:Chromatin modifying enzymes", "R-XTR-1632852:r:Macroautophagy", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-1632852:r:Macroautophagy", "R-XTR-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9673766:r:Signaling by cytosolic PDGFRA and PDGFRB fusion proteins", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-165159:r:MTOR signalling", "R-BTA-165159:r:MTOR signalling", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-BTA-9646399:r:Aggrephagy", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-SPO-1632852:r:Macroautophagy", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-SSC-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-114608:r:Platelet degranulation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-MMU-8852405:r:Signaling by MST1", "R-CEL-202040:r:G-protein activation", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DDI-3295583:r:TRP channels", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-5626978:r:TNFR1-mediated ceramide production", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-983189:r:Kinesins", "R-SCE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-DRE-4641265:r:Repression of WNT target genes", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-DRE-202040:r:G-protein activation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-418217:r:G beta:gamma signalling through PLC beta", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-BTA-3214841:r:PKMTs methylate histone lysines", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-6806942:r:MET Receptor Activation", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-1632852:r:Macroautophagy", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-3214815:r:HDACs deacetylate histones", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-5610787:r:Hedgehog 'off' state", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-9033241:r:Peroxisomal protein import", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-SSC-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-DME-114608:r:Platelet degranulation", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-420092:r:Glucagon-type ligand receptors", "R-RNO-72649:r:Translation initiation complex formation", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-167161:r:HIV Transcription Initiation", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-9646399:r:Aggrephagy", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-DME-432620:r:Dephosphorylation of PER", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-418597:r:G alpha (z) signalling events", "R-CEL-418597:r:G alpha (z) signalling events", "R-CFA-416476:r:G alpha (q) signalling events", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CEL-72649:r:Translation initiation complex formation", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-GGA-8951664:r:Neddylation", "R-MMU-418597:r:G alpha (z) signalling events", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-DME-209396:r:Phosphorylation of ARM", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SSC-8851907:r:MET activates PI3K/AKT signaling", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-BTA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DME-9646399:r:Aggrephagy", "R-CEL-381070:r:IRE1alpha activates chaperones", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-SSC-8865999:r:MET activates PTPN11", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-CFA-381753:r:Olfactory Signaling Pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-525793:r:Myogenesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-DME-9013420:r:RHOU GTPase cycle", "R-GGA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-418597:r:G alpha (z) signalling events", "R-DME-8951664:r:Neddylation", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-DME-9930044:r:Nuclear RNA decay", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-MMU-202040:r:G-protein activation", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-8980692:r:RHOA GTPase cycle", "R-BTA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DRE-1538133:r:G0 and Early G1", "R-CEL-4641265:r:Repression of WNT target genes", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-9696273:r:RND1 GTPase cycle", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-429947:r:Deadenylation of mRNA", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-CFA-500657:r:Presynaptic function of Kainate receptors", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-69231:r:Cyclin D associated events in G1", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-4641265:r:Repression of WNT target genes", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-3214815:r:HDACs deacetylate histones", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-4641265:r:Repression of WNT target genes", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-CEL-418594:r:G alpha (i) signalling events", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SSC-8875791:r:MET activates STAT3", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-6811438:r:Intra-Golgi traffic", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-CFA-418597:r:G alpha (z) signalling events", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-9930044:r:Nuclear RNA decay", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DRE-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-XTR-8943724:r:Regulation of PTEN gene transcription", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SSC-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-4641265:r:Repression of WNT target genes", "R-HSA-9022537:r:Loss of MECP2 binding ability to the NCoR/SMRT complex", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-3214847:r:HATs acetylate histones", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-5620924:r:Intraflagellar transport", "R-DME-1538133:r:G0 and Early G1", "R-BTA-1632852:r:Macroautophagy", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-CEL-6782135:r:Dual incision in TC-NER", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-416700:r:Other semaphorin interactions", "R-SPO-8951664:r:Neddylation", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5620924:r:Intraflagellar transport", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-9766229:r:Degradation of CDH1", "R-XTR-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-8865999:r:MET activates PTPN11", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-SCE-429947:r:Deadenylation of mRNA", "R-DME-350054:r:Notch-HLH transcription pathway", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CFA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-DRE-5626978:r:TNFR1-mediated ceramide production", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-381042:r:PERK regulates gene expression", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-CFA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-4086398:r:Ca2+ pathway", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9707616:r:Heme signaling", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-DDI-1266695:r:Interleukin-7 signaling", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-GGA-1632852:r:Macroautophagy", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DME-428930:r:Thromboxane signalling through TP receptor", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-5694530:r:Cargo concentration in the ER", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-418594:r:G alpha (i) signalling events", "R-DRE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-CEL-428930:r:Thromboxane signalling through TP receptor", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-8865999:r:MET activates PTPN11", "R-DRE-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-212436:r:Generic Transcription Pathway", "R-CEL-525793:r:Myogenesis", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-BTA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-SCE-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-9770562:r:mRNA Polyadenylation", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-114608:r:Platelet degranulation", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-SPO-114608:r:Platelet degranulation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-DRE-2132295:r:MHC class II antigen presentation", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DDI-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-166208:r:mTORC1-mediated signalling", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-8875791:r:MET activates STAT3", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-XTR-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-RNO-428930:r:Thromboxane signalling through TP receptor", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-72649:r:Translation initiation complex formation", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-6806942:r:MET Receptor Activation", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SSC-8875656:r:MET receptor recycling", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-SPO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-5689880:r:Ub-specific processing proteases", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-114608:r:Platelet degranulation", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-MMU-9013420:r:RHOU GTPase cycle", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-CFA-177929:r:Signaling by EGFR", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DRE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-420092:r:Glucagon-type ligand receptors", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-GGA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-1632852:r:Macroautophagy", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-191859:r:snRNP Assembly", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-1538133:r:G0 and Early G1", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-SPO-9013420:r:RHOU GTPase cycle", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-DDI-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-1538133:r:G0 and Early G1", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-GGA-6783310:r:Fanconi Anemia Pathway", "R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-1632852:r:Macroautophagy", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-HSA-156711:r:Polo-like kinase mediated events", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-BTA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-418594:r:G alpha (i) signalling events", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-9770562:r:mRNA Polyadenylation", "R-XTR-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8875656:r:MET receptor recycling", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DRE-381753:r:Olfactory Signaling Pathway", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-72187:r:mRNA 3'-end processing", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-420092:r:Glucagon-type ligand receptors", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-SSC-6811558:r:PI5P, PP2A and IER3 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between G1/S and early anaphase", "R-MMU-5620924:r:Intraflagellar transport", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-2485179:r:Activation of the phototransduction cascade", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-9833482:r:PKR-mediated signaling", "R-RNO-381042:r:PERK regulates gene expression", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-416476:r:G alpha (q) signalling events", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-BTA-418555:r:G alpha (s) signalling events", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-1296041:r:Activation of G protein gated Potassium channels", "R-SPO-429947:r:Deadenylation of mRNA", "R-GGA-8854518:r:AURKA Activation by TPX2", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-CEL-1632852:r:Macroautophagy", "R-CEL-416700:r:Other semaphorin interactions", 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metabolism of PAPS", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-DDI-171319:r:Telomere Extension By Telomerase", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Homologous_superfamily"}, "IPR015948": {"description": "Bacteriophage PRD1, P2, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_PRD1_P2_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015949": {"description": "Bacteriophage PRD1, P2, N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_PRD1_P2_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015950": {"description": "Chemokine-binding M3, subdomain 1, viral", "go_ids": ["GO:0019956"], "go_terms": ["GO:0019956:chemokine binding:F"], "name": "Chemokine-bd_M3_sub1_vir", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015951": {"description": "Chemokine-binding M3, subdomain 2, viral", "go_ids": ["GO:0019956"], "go_terms": ["GO:0019956:chemokine binding:F"], "name": "Chemokine-bd_M3_sub2_vir", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015952": {"description": "Methane monooxygenase, gamma chain, domain 1", "go_ids": ["GO:0015049", "GO:0015947"], "go_terms": ["GO:0015049:methane monooxygenase [NAD(P)H] activity:F", "GO:0015947:methane metabolic process:P"], "name": "Me_mOase_g_dom1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015953": {"description": "Methane monooxygenase, gamma chain, domain 2", "go_ids": ["GO:0015049", "GO:0015947"], "go_terms": ["GO:0015049:methane monooxygenase [NAD(P)H] activity:F", "GO:0015947:methane metabolic process:P"], "name": "Me_mOase_g_dom2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015954": {"description": "Bacteriophage RNA-type, capsid", "go_ids": [], "go_terms": [], "name": "Phage_RNA-type_capsid", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015955": {"description": "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal", "go_ids": ["GO:0003824", "GO:0016616"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "Lactate_DH/Glyco_Ohase_4_C", "pathway_ids": ["PWY-7383", "PWY-8086", "PWY-1622", "PWY-6728", "PWY-7115", "PWY-561", "PWY-5690", "PWY-5392", "PWY-6969", "R-MMU-9837999", "R-HSA-9856872", "R-MMU-9861718", "R-XTR-9856872", "R-HSA-9861718", "R-DDI-9856872", "R-RNO-70268", "R-SPO-71403", "R-CEL-71403", "R-MMU-71403", "R-BTA-9837999", "R-GGA-373920", "R-GGA-70268", "R-HSA-9837999", "R-RNO-71403", "R-SPO-9856872", "R-BTA-9856872", "R-HSA-71403", "R-MMU-70268", "R-DRE-9861718", "R-CEL-9837999", "R-BTA-71403", "R-BTA-9861718", "R-RNO-9837999", "R-GGA-352875", "R-DME-9861718", "R-CEL-9856872", "R-HSA-70268", "R-BTA-70268", "R-SCE-9856872", "R-DME-70268", "R-CEL-70268", "R-DRE-70268", "R-SPO-9837999", "R-SSC-9856872", "R-SCE-71403", 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"Domain"}, "IPR015966": {"description": "tRNA ligase, kinase domain, fungi", "go_ids": ["GO:0003972", "GO:0005524", "GO:0006388"], "go_terms": ["GO:0003972:RNA ligase (ATP) activity:F", "GO:0005524:ATP binding:F", "GO:0006388:tRNA splicing, via endonucleolytic cleavage and ligation:P"], "name": "tRNA_lig_kin_fungi", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015967": {"description": "Recombination protein RecR, zinc finger domain", "go_ids": ["GO:0046872", "GO:0006281", "GO:0006310"], "go_terms": ["GO:0046872:metal ion binding:F", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P"], "name": "Rcmb_RecR_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR015969": {"description": "P40 nucleoprotein, subdomain 1, Borna disease virus", "go_ids": [], "go_terms": [], "name": "P40_nucleoprot_sub1_BD-vir", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR015970": {"description": "P40 nucleoprotein, subdomain 2, Borna disease virus", 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"R-HSA-975634", "R-CEL-8951664", "R-HSA-5358346", "R-MMU-1222556", "R-SSC-5663220", "R-RNO-9020702", "R-RNO-6807505", "R-MMU-1660516", "R-DME-1222556", "R-CEL-6798695", "R-SCE-1660514", "R-HSA-69273", "R-HSA-9932298", "R-BTA-6798695", "R-HSA-9670439", "R-DME-380972", "R-RNO-912526"], "pathways": ["R-DDI-8951664:r:Neddylation", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-8951664:r:Neddylation", "R-CEL-9018681:r:Biosynthesis of protectins", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-5689603:r:UCH proteinases", "R-BTA-8853659:r:RET signaling", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SPO-72086:r:mRNA Capping", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-69481:r:G2/M Checkpoints", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-GGA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SPO-5689603:r:UCH proteinases", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-DME-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-DME-209421:r:Transcription activation by ARM", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-DDI-9930044:r:Nuclear RNA decay", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DME-525793:r:Myogenesis", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-8964046:r:VLDL clearance", "R-CEL-416476:r:G alpha (q) signalling events", "R-MMU-198203:r:PI3K/AKT activation", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-DDI-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-BTA-201556:r:Signaling by ALK", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-8849473:r:PTK6 Expression", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-DME-216167:r:Nuclear CI is degraded", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9013424:r:RHOV GTPase cycle", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9907900:r:Proteasome assembly", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-SCE-72086:r:mRNA Capping", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-72649:r:Translation initiation complex formation", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-8964038:r:LDL clearance", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-HSA-165159:r:MTOR signalling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-917937:r:Iron uptake and transport", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9033241:r:Peroxisomal protein import", "R-CEL-4641257:r:Degradation of AXIN", "R-SSC-5673000:r:RAF activation", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-SPO-437239:r:Recycling pathway of L1", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-DDI-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9607240:r:FLT3 Signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-5673000:r:RAF activation", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-525793:r:Myogenesis", "R-SSC-9764561:r:Regulation of CDH1 Function", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-RNO-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-CEL-165159:r:MTOR signalling", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-8964038:r:LDL clearance", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-69231:r:Cyclin D associated events in G1", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-77387:r:Insulin receptor recycling", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-4086400:r:PCP/CE pathway", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9609690:r:HCMV Early Events", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-GGA-72649:r:Translation initiation complex formation", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8951664:r:Neddylation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-SPO-196025:r:Formation of annular gap junctions", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-BTA-68949:r:Orc1 removal from chromatin", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-DME-3214858:r:RMTs methylate histone arginines", "R-HSA-68877:r:Mitotic Prometaphase", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-191859:r:snRNP Assembly", "R-DME-389513:r:Co-inhibition by CTLA4", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-DRE-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-912631:r:Regulation of signaling by CBL", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-9018681:r:Biosynthesis of protectins", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-DRE-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-8963888:r:Chylomicron assembly", "R-GGA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-77387:r:Insulin receptor recycling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-9733709:r:Cardiogenesis", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-RNO-9018681:r:Biosynthesis of protectins", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-BTA-9607240:r:FLT3 Signaling", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-XTR-72086:r:mRNA Capping", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-9013424:r:RHOV GTPase cycle", "R-BTA-8951430:r:RUNX3 regulates WNT signaling", "R-SSC-9013026:r:RHOB GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-429947:r:Deadenylation of mRNA", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-164944:r:Nef and signal transduction", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-SSC-418990:r:Adherens junctions interactions", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-432142:r:Platelet sensitization by LDL", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-6811438:r:Intra-Golgi traffic", "R-CEL-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5467333:r:APC truncation mutants are not K63 polyubiquitinated", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-BTA-9018681:r:Biosynthesis of protectins", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-BTA-8951664:r:Neddylation", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-8951430:r:RUNX3 regulates WNT signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-4641258:r:Degradation of DVL", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-8964038:r:LDL clearance", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-GGA-72165:r:mRNA Splicing - Minor Pathway", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-SPO-72649:r:Translation initiation complex formation", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SSC-6809371:r:Formation of the cornified envelope", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-198753:r:ERK/MAPK targets", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-525793:r:Myogenesis", "R-SCE-198753:r:ERK/MAPK targets", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-198203:r:PI3K/AKT activation", "R-SPO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-68877:r:Mitotic Prometaphase", "R-SSC-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-418990:r:Adherens junctions interactions", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-69481:r:G2/M Checkpoints", "R-SPO-917937:r:Iron uptake and transport", "R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-4086398:r:Ca2+ pathway", "R-GGA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-8964038:r:LDL clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-BTA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-XTR-6807878:r:COPI-mediated anterograde transport", "R-BTA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-437239:r:Recycling pathway of L1", "R-MMU-5673000:r:RAF activation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DDI-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-9696264:r:RND3 GTPase cycle", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-191859:r:snRNP Assembly", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-8980692:r:RHOA GTPase cycle", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9907900:r:Proteasome assembly", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-112399:r:IRS-mediated signalling", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-9833482:r:PKR-mediated signaling", "R-XTR-191859:r:snRNP Assembly", "R-SPO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-180292:r:GAB1 signalosome", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SPO-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-8964026:r:Chylomicron clearance", "R-HSA-109704:r:PI3K Cascade", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-8853884:r:Transcriptional Regulation by VENTX", "R-DME-9020702:r:Interleukin-1 signaling", "R-SSC-9013106:r:RHOC GTPase cycle", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-9833482:r:PKR-mediated signaling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-8964038:r:LDL clearance", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-9764561:r:Regulation of CDH1 Function", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DRE-9013407:r:RHOH GTPase cycle", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-373753:r:Nephrin family interactions", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-201556:r:Signaling by ALK", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-210993:r:Tie2 Signaling", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-SCE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-BTA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-4641257:r:Degradation of AXIN", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-BTA-5673000:r:RAF activation", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-432142:r:Platelet sensitization by LDL", "R-CEL-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-9930044:r:Nuclear RNA decay", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-CEL-190873:r:Gap junction degradation", "R-HSA-977225:r:Amyloid fiber formation", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-109704:r:PI3K Cascade", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-9842663:r:Signaling by LTK", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-BTA-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-5689603:r:UCH proteinases", "R-GGA-9930044:r:Nuclear RNA decay", "R-DDI-2468052:r:Establishment of Sister Chromatid Cohesion", "R-XTR-6803529:r:FGFR2 alternative splicing", "R-HSA-5610787:r:Hedgehog 'off' state", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-SCE-9018676:r:Biosynthesis of D-series resolvins", "R-HSA-525793:r:Myogenesis", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-209190:r:Phosphorylation of CI", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-SPO-9018676:r:Biosynthesis of D-series resolvins", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-DDI-202670:r:ERKs are inactivated", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-4086398:r:Ca2+ pathway", "R-CEL-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-DRE-912446:r:Meiotic recombination", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-9018676:r:Biosynthesis of D-series resolvins", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-3295583:r:TRP channels", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-SCE-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-5578775:r:Ion homeostasis", "R-RNO-5610787:r:Hedgehog 'off' state", "R-CEL-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DME-2467813:r:Separation of Sister Chromatids", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-389356:r:Co-stimulation by CD28", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-429947:r:Deadenylation of mRNA", "R-DRE-9764561:r:Regulation of CDH1 Function", "R-HSA-9696264:r:RND3 GTPase cycle", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-8854214:r:TBC/RABGAPs", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-165159:r:MTOR signalling", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-983189:r:Kinesins", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CEL-9907900:r:Proteasome assembly", "R-CEL-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-RNO-4641257:r:Degradation of AXIN", "R-DME-9907900:r:Proteasome assembly", "R-GGA-72086:r:mRNA Capping", "R-DDI-5689603:r:UCH proteinases", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-8951430:r:RUNX3 regulates WNT signaling", "R-RNO-9707616:r:Heme signaling", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-BTA-5632684:r:Hedgehog 'on' state", "R-MMU-109704:r:PI3K Cascade", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-DDI-392517:r:Rap1 signalling", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-8964041:r:LDL remodeling", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-BTA-109704:r:PI3K Cascade", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-201556:r:Signaling by ALK", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-CEL-166208:r:mTORC1-mediated signalling", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-8964038:r:LDL clearance", "R-SSC-180024:r:DARPP-32 events", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-9607240:r:FLT3 Signaling", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-CEL-912631:r:Regulation of signaling by CBL", "R-MMU-69541:r:Stabilization of p53", "R-BTA-190873:r:Gap junction degradation", "R-DDI-5632684:r:Hedgehog 'on' state", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-389356:r:Co-stimulation by CD28", "R-HSA-418457:r:cGMP effects", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-201556:r:Signaling by ALK", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-9013407:r:RHOH GTPase cycle", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-72086:r:mRNA Capping", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-912631:r:Regulation of signaling by CBL", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-XTR-9930044:r:Nuclear RNA decay", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SPO-9013424:r:RHOV GTPase cycle", "R-DDI-68949:r:Orc1 removal from chromatin", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-SSC-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-202670:r:ERKs are inactivated", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-GGA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-BTA-9766229:r:Degradation of CDH1", "R-CEL-201681:r:TCF dependent signaling in response to WNT", "R-DME-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-DME-6783310:r:Fanconi Anemia Pathway", "R-MMU-9018681:r:Biosynthesis of protectins", "R-SSC-68877:r:Mitotic Prometaphase", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-RNO-166166:r:MyD88-independent TLR4 cascade", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-RNO-190873:r:Gap junction degradation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-5689603:r:UCH proteinases", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-9013407:r:RHOH GTPase cycle", "R-DME-8951430:r:RUNX3 regulates WNT signaling", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-GGA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-9764561:r:Regulation of CDH1 Function", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-163615:r:PKA activation", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-3295583:r:TRP channels", "R-RNO-9013026:r:RHOB GTPase cycle", "R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-DDI-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-DDI-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-2470946:r:Cohesin Loading onto Chromatin", "R-SPO-9930044:r:Nuclear RNA decay", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SSC-9833482:r:PKR-mediated signaling", "R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-5610787:r:Hedgehog 'off' state", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SCE-166208:r:mTORC1-mediated signalling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-HSA-202670:r:ERKs are inactivated", "R-DME-432524:r:Degradation of PER", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-XTR-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-1632852:r:Macroautophagy", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-DDI-9018676:r:Biosynthesis of D-series resolvins", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-DDI-437239:r:Recycling pathway of L1", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-DME-72649:r:Translation initiation complex formation", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-9930044:r:Nuclear RNA decay", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-162592:r:Integration of provirus", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-912446:r:Meiotic recombination", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-6805567:r:Keratinization", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DRE-6809371:r:Formation of the cornified envelope", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-BTA-5218920:r:VEGFR2 mediated vascular permeability", "R-XTR-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-SSC-6805567:r:Keratinization", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-CEL-210993:r:Tie2 Signaling", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DME-9707616:r:Heme signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-DDI-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-DRE-5626467:r:RHO GTPases activate IQGAPs", "R-SCE-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-112399:r:IRS-mediated signalling", "R-XTR-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DRE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-165159:r:MTOR signalling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking", "R-DRE-4086398:r:Ca2+ pathway", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-DME-9764561:r:Regulation of CDH1 Function", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-SPO-1632852:r:Macroautophagy", "R-HSA-9013407:r:RHOH GTPase cycle", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-140342:r:Apoptosis induced DNA fragmentation", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-RNO-9762292:r:Regulation of CDH11 function", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-9764561:r:Regulation of CDH1 Function", "R-DME-5689603:r:UCH proteinases", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-4086398:r:Ca2+ pathway", "R-HSA-180024:r:DARPP-32 events", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-6809371:r:Formation of the cornified envelope", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-RNO-5578775:r:Ion homeostasis", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-DDI-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-SCE-437239:r:Recycling pathway of L1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-983189:r:Kinesins", "R-CEL-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-983712:r:Ion channel transport", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DDI-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9607240:r:FLT3 Signaling", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9018676:r:Biosynthesis of D-series resolvins", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-69481:r:G2/M Checkpoints", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-525793:r:Myogenesis", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-1632852:r:Macroautophagy", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-3214815:r:HDACs deacetylate histones", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-5626467:r:RHO GTPases activate IQGAPs", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-SSC-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-198753:r:ERK/MAPK targets", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-196025:r:Formation of annular gap junctions", "R-HSA-5620924:r:Intraflagellar transport", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-9013407:r:RHOH GTPase cycle", "R-SSC-432142:r:Platelet sensitization by LDL", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DME-6809371:r:Formation of the cornified envelope", "R-RNO-180024:r:DARPP-32 events", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-432620:r:Dephosphorylation of PER", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-CEL-72649:r:Translation initiation complex formation", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-SCE-196025:r:Formation of annular gap junctions", "R-SPO-2871796:r:FCERI mediated MAPK activation", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-77387:r:Insulin receptor recycling", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-BTA-2424491:r:DAP12 signaling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9664873:r:Pexophagy", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-MMU-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-DME-209396:r:Phosphorylation of ARM", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-XTR-77595:r:Processing of Intronless Pre-mRNAs", "R-SSC-5218920:r:VEGFR2 mediated vascular permeability", "R-GGA-9770562:r:mRNA Polyadenylation", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SSC-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-917937:r:Iron uptake and transport", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-525793:r:Myogenesis", "R-CEL-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-SCE-190873:r:Gap junction degradation", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-9013420:r:RHOU GTPase cycle", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-6805567:r:Keratinization", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-8854214:r:TBC/RABGAPs", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-8951664:r:Neddylation", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DME-9930044:r:Nuclear RNA decay", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-RNO-112399:r:IRS-mediated signalling", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-9035034:r:RHOF GTPase cycle", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-GGA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9610379:r:HCMV Late Events", "R-DRE-9013106:r:RHOC GTPase cycle", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-BTA-418990:r:Adherens junctions interactions", "R-DME-8980692:r:RHOA GTPase cycle", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-9830364:r:Formation of the nephric duct", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-8853659:r:RET signaling", "R-SPO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-69473:r:G2/M DNA damage checkpoint", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-6798695:r:Neutrophil degranulation", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-389356:r:Co-stimulation by CD28", "R-GGA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-418990:r:Adherens junctions interactions", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-112043:r:PLC beta mediated events", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DDI-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-DRE-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-68949:r:Orc1 removal from chromatin", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-SSC-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6809371:r:Formation of the cornified envelope", "R-DDI-171007:r:p38MAPK events", "R-SSC-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9013420:r:RHOU GTPase cycle", "R-CEL-9954709:r:Ribosome 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and cytosol", "R-DDI-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-DME-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DME-190873:r:Gap junction degradation", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-77387:r:Insulin receptor recycling", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-72086:r:mRNA Capping", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-9707616:r:Heme signaling", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-GGA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-DRE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SPO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-77387:r:Insulin receptor recycling", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-5620924:r:Intraflagellar transport", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-SCE-429947:r:Deadenylation of mRNA", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-190873:r:Gap junction degradation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-166208:r:mTORC1-mediated signalling", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-4086398:r:Ca2+ pathway", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-8964038:r:LDL clearance", "R-RNO-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-202670:r:ERKs are inactivated", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-196025:r:Formation of annular gap junctions", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9707616:r:Heme signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-209407:r:Transport of ARM to the nucleus", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-9664873:r:Pexophagy", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-198753:r:ERK/MAPK targets", "R-SCE-9018681:r:Biosynthesis of protectins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-8980692:r:RHOA GTPase cycle", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-DME-201681:r:TCF dependent signaling in response to WNT", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-DME-5673000:r:RAF activation", "R-CEL-525793:r:Myogenesis", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-5218920:r:VEGFR2 mediated vascular permeability", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-6805567:r:Keratinization", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-180292:r:GAB1 signalosome", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-4641258:r:Degradation of DVL", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DDI-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-198753:r:ERK/MAPK targets", "R-HSA-9018681:r:Biosynthesis of protectins", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-186763:r:Downstream signal transduction", "R-SPO-8964038:r:LDL clearance", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-180024:r:DARPP-32 events", "R-SPO-5620916:r:VxPx cargo-targeting to cilium", "R-DME-166208:r:mTORC1-mediated signalling", "R-DME-9013406:r:RHOQ GTPase cycle", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-72086:r:mRNA Capping", "R-BTA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-BTA-983712:r:Ion channel transport", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DRE-72649:r:Translation initiation complex formation", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-983712:r:Ion channel transport", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-69541:r:Stabilization of p53", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DDI-1169092:r:Activation of RAS in B cells", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-CEL-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-1489509:r:DAG and IP3 signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-SCE-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-8854214:r:TBC/RABGAPs", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-9013420:r:RHOU GTPase cycle", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-HSA-8853659:r:RET signaling", "R-DDI-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-192905:r:vRNP Assembly", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-DDI-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5673000:r:RAF activation", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-2424491:r:DAP12 signaling", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DME-196025:r:Formation of annular gap junctions", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SCE-202670:r:ERKs are inactivated", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-BTA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-SPO-190873:r:Gap junction degradation", "R-BTA-917937:r:Iron uptake and transport", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-DME-1632852:r:Macroautophagy", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-DDI-983712:r:Ion channel transport", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9636467:r:Blockage of phagosome acidification", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SSC-9762292:r:Regulation of CDH11 function", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-8866423:r:VLDL assembly", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-9770562:r:mRNA Polyadenylation", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-202670:r:ERKs are inactivated", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9664873:r:Pexophagy", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-917937:r:Iron uptake and transport", "R-MMU-190873:r:Gap junction degradation", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-418457:r:cGMP effects", "R-BTA-437239:r:Recycling pathway of L1", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-SSC-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DDI-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DRE-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-MMU-437239:r:Recycling pathway of L1", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-1632852:r:Macroautophagy", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-9907900:r:Proteasome assembly", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-166208:r:mTORC1-mediated signalling", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-SPO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-DME-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-354192:r:Integrin signaling", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-SSC-198753:r:ERK/MAPK targets", "R-BTA-196025:r:Formation of annular gap junctions", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-9762292:r:Regulation of CDH11 function", "R-BTA-9013424:r:RHOV GTPase cycle", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-RNO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-9013407:r:RHOH GTPase cycle", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-196025:r:Formation of annular gap junctions", "R-HSA-9823730:r:Formation of definitive endoderm", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-9664873:r:Pexophagy", "R-SCE-9013420:r:RHOU GTPase cycle", "R-HSA-9796292:r:Formation of axial mesoderm", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-2470946:r:Cohesin Loading onto Chromatin", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DRE-8853884:r:Transcriptional Regulation by VENTX", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-4641258:r:Degradation of DVL", "R-RNO-8853659:r:RET signaling", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CEL-8866427:r:VLDLR internalisation and degradation", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-416476:r:G alpha (q) signalling events", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-CEL-6809371:r:Formation of the cornified envelope", "R-GGA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-429947:r:Deadenylation of mRNA", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-6805567:r:Keratinization", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-382556:r:ABC-family proteins mediated transport", "R-CEL-1632852:r:Macroautophagy", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-SPO-9018681:r:Biosynthesis of protectins", "R-HSA-416476:r:G alpha (q) signalling events", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-XTR-72165:r:mRNA Splicing - Minor Pathway", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DDI-2871796:r:FCERI mediated MAPK activation", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-CEL-9018676:r:Biosynthesis of D-series resolvins", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-9764561:r:Regulation of CDH1 Function", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-196025:r:Formation of annular gap junctions", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-DME-9033241:r:Peroxisomal protein import", "R-DME-77387:r:Insulin receptor recycling", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-XTR-68877:r:Mitotic Prometaphase", "R-XTR-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-389356:r:Co-stimulation by CD28", "R-DME-538864:r:Degradation of CRY", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9907900:r:Proteasome assembly", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-2424491:r:DAP12 signaling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-CEL-6803529:r:FGFR2 alternative splicing", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-XTR-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8951664:r:Neddylation", "R-HSA-77387:r:Insulin receptor recycling", "R-MMU-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-8963901:r:Chylomicron remodeling", "R-HSA-69231:r:Cyclin D associated events in G1", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-XTR-113418:r:Formation of the Early Elongation Complex", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-201556:r:Signaling by ALK", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-6805567:r:Keratinization", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DDI-198753:r:ERK/MAPK targets", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-RNO-165159:r:MTOR signalling", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-77387:r:Insulin receptor recycling", "R-DME-4641257:r:Degradation of AXIN", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-202670:r:ERKs are inactivated", "R-DRE-201681:r:TCF dependent signaling in response to WNT", "R-HSA-389356:r:Co-stimulation by CD28", "R-DME-983712:r:Ion channel transport", "R-CEL-8964038:r:LDL clearance", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-XTR-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-DME-165159:r:MTOR signalling", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-SSC-6798695:r:Neutrophil degranulation", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-9824272:r:Somitogenesis", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-166208:r:mTORC1-mediated signalling", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-166208:r:mTORC1-mediated signalling", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-MMU-429947:r:Deadenylation of mRNA", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-XTR-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-69231:r:Cyclin D associated events in G1", "R-DDI-917937:r:Iron uptake and transport", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-983712:r:Ion channel transport", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-9833576:r:CDH11 homotypic and heterotypic interactions", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-975634:r:Retinoid metabolism and transport", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-RNO-9020702:r:Interleukin-1 signaling", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-912526:r:Interleukin receptor SHC signaling"], "type": "Homologous_superfamily"}, "IPR016025": {"description": "Clathrin heavy chain, N-terminal", "go_ids": ["GO:0005198", "GO:0006886", "GO:0016192", "GO:0030130", "GO:0030132"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P", "GO:0030130:clathrin coat of trans-Golgi network vesicle:C", "GO:0030132:clathrin coat of coated pit:C"], "name": "Clathrin_H-chain_N", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-SPO-437239", "R-SCE-8856828", "R-DME-190873", "R-BTA-196025", "R-BTA-9013424", "R-HSA-9700645", "R-HSA-8856828", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-9013424", "R-CEL-432722", "R-HSA-9013424", "R-RNO-8964038", "R-BTA-190873", "R-DME-5099900", "R-MMU-9013420", "R-RNO-9013424", "R-RNO-196025", "R-RNO-177504", "R-DDI-8856828", "R-SCE-9013420", "R-DME-3928665", "R-DME-8964038", "R-DDI-8964038", "R-DME-177504", "R-HSA-5140745", "R-RNO-8866427", "R-RNO-432722", "R-MMU-196025", "R-BTA-5099900", "R-RNO-432720", "R-DME-437239", "R-HSA-432720", "R-DME-196025", "R-DME-5140745", "R-HSA-437239", "R-CEL-8866427", "R-BTA-177504", "R-MMU-5140745", "R-SPO-8866427", "R-CEL-8964038", "R-SPO-190873", "R-MMU-8866427", "R-SPO-9013424", "R-SCE-196025", "R-SPO-196025", 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L1", "R-CEL-8866427:r:VLDLR internalisation and degradation", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-CEL-8964038:r:LDL clearance", "R-SPO-190873:r:Gap junction degradation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SCE-196025:r:Formation of annular gap junctions", "R-SPO-196025:r:Formation of annular gap junctions", "R-RNO-9013420:r:RHOU GTPase cycle", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", 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"R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-190873:r:Gap junction degradation", "R-HSA-8964038:r:LDL clearance", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Homologous_superfamily"}, "IPR016029": {"description": "Inner layer core protein VP3, Reovirus", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Inner_layer_core_VP3_Reovir", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016030": {"description": "Cobalamin adenosyltransferase-like", "go_ids": [], "go_terms": [], "name": "CblAdoTrfase-like", "pathway_ids": ["R-HSA-9759218", "R-HSA-3359471", "R-MMU-9759218"], "pathways": ["R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-3359471:r:Defective MMAB causes MMA, cblB type", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism"], "type": "Domain"}, "IPR016031": {"description": "Tryptophan RNA-binding attenuator protein-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Trp_RNA-bd_attenuator-like_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016032": {"description": "Signal transduction response regulator, C-terminal effector", 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"R-SCE-77289", "R-RNO-6811436", "R-XTR-1482798", "R-MMU-1483166", "R-DRE-1483166", "R-BTA-6811436", "R-MMU-1482883", "R-HSA-1482839", "R-BTA-2142753", "R-XTR-2142753", "R-SPO-432142", "R-SPO-1482801", "R-HSA-1483152", "R-HSA-1482788", "R-HSA-9029558", "R-SCE-418592", "R-SCE-2142753", "R-GGA-1482788", "R-HSA-6814848", "R-MMU-2142753", "R-XTR-432142", "R-HSA-2029485", "R-SCE-1482925", "R-GGA-1482798", "R-RNO-75105", "R-HSA-199220", "R-GGA-1482925", "R-DME-6814848", "R-HSA-1483166", "R-HSA-1482925", "R-RNO-199220", "R-SCE-6811436", "R-GGA-111995", "R-DRE-1483115", "R-BTA-1483166", "R-RNO-1482925", "R-CEL-1482883", "R-HSA-1483115", "R-HSA-6811436", "R-HSA-163765", "R-HSA-381038", "R-CEL-163560", "R-DME-77289", "R-DRE-111995", "R-SCE-1483115", "R-MMU-75105", "R-HSA-1482798", "R-HSA-1482801", "R-SCE-1482801", "R-SPO-1482922", "R-HSA-1482883", "R-BTA-1482922", "R-SPO-6814848", "R-SCE-1483166", "R-DRE-418592", "R-XTR-1482925", "R-HSA-2426168", "R-XTR-6811436", "R-RNO-1482798", "R-MMU-111995", "R-SPO-418592", "R-SCE-1482798", "R-GGA-1482839", "R-DDI-75105", "R-RNO-1483166", "R-XTR-418592", "R-HSA-432142", "R-BTA-1482801", "R-MMU-8957275", "R-HSA-9841922", "R-MMU-432142", "R-RNO-1482788", "R-RNO-2029485", "R-SPO-1482798", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-SCE-1482839", "R-DDI-199220", "R-MMU-1482798", "R-BTA-1482798", "R-SCE-1482922", "R-MMU-2029485", "R-RNO-1482839", "R-GGA-1482922", "R-RNO-1482801", "R-HSA-381426", "R-MMU-1483152", "R-SCE-432142", "R-DRE-1482798", "R-DRE-432142", "R-BTA-432142", "R-RNO-1483115", "R-RNO-1482922", "R-BTA-1482925", "R-DRE-1482925", "R-DRE-1482788", "R-SPO-6811436", "R-BTA-111995", "R-SPO-1483115", "R-MMU-6811436", "R-RNO-381426", "R-BTA-418592", "R-HSA-75105", "R-MMU-77289", "R-SCE-6814848", "R-SCE-1482788", "R-RNO-432142", "R-GGA-1482801", "R-XTR-1482922", "R-GGA-418592", "R-BTA-1482788", "R-XTR-1483166", "R-MMU-1483115", "R-HSA-1482922", "R-SPO-1483166", "R-RNO-8957275", "R-DRE-1482839", "R-DRE-2142753", "R-MMU-1482925", "R-HSA-9918481", "R-XTR-1482839", "R-SCE-1483152", "R-GGA-6811436", "R-RNO-2142753", "R-MMU-6814848", "R-XTR-111995", "R-HSA-2142753", "R-DRE-1482922", "R-GGA-432142", "R-HSA-163560", "R-MMU-418592", "R-HSA-111995", "R-XTR-1482788", "R-MMU-1482922", "R-SPO-1482788", "R-GGA-2142753", "R-DRE-1482801", "R-HSA-8957275", "R-SPO-77289", "R-MMU-1482801", "R-DRE-6811436"], "pathways": ["R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-1483115:r:Hydrolysis of LPC", "R-XTR-1482801:r:Acyl chain remodelling of PS", "R-SPO-1482925:r:Acyl chain remodelling of PG", "R-RNO-111995:r:phospho-PLA2 pathway", "R-SPO-2142753:r:Arachidonate metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SPO-1482839:r:Acyl chain remodelling of PE", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-1482883:r:Acyl chain remodeling of DAG and TAG", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-XTR-1483115:r:Hydrolysis of LPC", 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"R-XTR-2142753:r:Arachidonate metabolism", "R-SPO-432142:r:Platelet sensitization by LDL", "R-SPO-1482801:r:Acyl chain remodelling of PS", "R-HSA-1483152:r:Hydrolysis of LPE", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-SCE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SCE-2142753:r:Arachidonate metabolism", "R-GGA-1482788:r:Acyl chain remodelling of PC", "R-HSA-6814848:r:Glycerophospholipid catabolism", "R-MMU-2142753:r:Arachidonate metabolism", "R-XTR-432142:r:Platelet sensitization by LDL", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-1482925:r:Acyl chain remodelling of PG", "R-GGA-1482798:r:Acyl chain remodeling of CL", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-GGA-1482925:r:Acyl chain remodelling of PG", "R-DME-6814848:r:Glycerophospholipid catabolism", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SCE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-GGA-111995:r:phospho-PLA2 pathway", "R-DRE-1483115:r:Hydrolysis of LPC", "R-BTA-1483166:r:Synthesis of PA", "R-RNO-1482925:r:Acyl chain remodelling of PG", "R-CEL-1482883:r:Acyl chain remodeling of DAG and TAG", "R-HSA-1483115:r:Hydrolysis of LPC", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-CEL-163560:r:Triglyceride catabolism", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DRE-111995:r:phospho-PLA2 pathway", "R-SCE-1483115:r:Hydrolysis of LPC", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-SCE-1482801:r:Acyl chain remodelling of PS", "R-SPO-1482922:r:Acyl chain remodelling of PI", "R-HSA-1482883:r:Acyl chain remodeling of DAG and TAG", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-SPO-6814848:r:Glycerophospholipid catabolism", "R-SCE-1483166:r:Synthesis of PA", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-XTR-1482925:r:Acyl chain remodelling of PG", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-XTR-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-1482798:r:Acyl chain remodeling of CL", "R-MMU-111995:r:phospho-PLA2 pathway", "R-SPO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SCE-1482798:r:Acyl chain remodeling of CL", "R-GGA-1482839:r:Acyl chain remodelling of PE", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-1483166:r:Synthesis of PA", "R-XTR-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-432142:r:Platelet sensitization by LDL", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SPO-1482798:r:Acyl chain remodeling of CL", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SCE-1482839:r:Acyl chain remodelling of PE", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-BTA-1482798:r:Acyl chain remodeling of CL", "R-SCE-1482922:r:Acyl chain remodelling of PI", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-GGA-1482922:r:Acyl chain remodelling of PI", "R-RNO-1482801:r:Acyl chain remodelling of PS", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1483152:r:Hydrolysis of LPE", "R-SCE-432142:r:Platelet sensitization by LDL", "R-DRE-1482798:r:Acyl chain remodeling of CL", "R-DRE-432142:r:Platelet sensitization by LDL", "R-BTA-432142:r:Platelet sensitization by LDL", "R-RNO-1483115:r:Hydrolysis of LPC", "R-RNO-1482922:r:Acyl chain remodelling of PI", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-DRE-1482925:r:Acyl chain remodelling of PG", "R-DRE-1482788:r:Acyl chain remodelling of PC", "R-SPO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-111995:r:phospho-PLA2 pathway", "R-SPO-1483115:r:Hydrolysis of LPC", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SCE-6814848:r:Glycerophospholipid catabolism", "R-SCE-1482788:r:Acyl chain remodelling of PC", "R-RNO-432142:r:Platelet sensitization by LDL", "R-GGA-1482801:r:Acyl chain remodelling of PS", "R-XTR-1482922:r:Acyl chain remodelling of PI", "R-GGA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-XTR-1483166:r:Synthesis of PA", "R-MMU-1483115:r:Hydrolysis of LPC", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-SPO-1483166:r:Synthesis of PA", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-DRE-1482839:r:Acyl chain remodelling of PE", "R-DRE-2142753:r:Arachidonate metabolism", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-XTR-1482839:r:Acyl chain remodelling of PE", "R-SCE-1483152:r:Hydrolysis of LPE", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-2142753:r:Arachidonate metabolism", "R-MMU-6814848:r:Glycerophospholipid catabolism", "R-XTR-111995:r:phospho-PLA2 pathway", "R-HSA-2142753:r:Arachidonate metabolism", "R-DRE-1482922:r:Acyl chain remodelling of PI", "R-GGA-432142:r:Platelet sensitization by LDL", "R-HSA-163560:r:Triglyceride catabolism", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-111995:r:phospho-PLA2 pathway", "R-XTR-1482788:r:Acyl chain remodelling of PC", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-SPO-1482788:r:Acyl chain remodelling of PC", "R-GGA-2142753:r:Arachidonate metabolism", "R-DRE-1482801:r:Acyl chain remodelling of PS", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR016036": {"description": "Malonyl-CoA ACP transacylase, ACP-binding", "go_ids": [], "go_terms": [], "name": "Malonyl_transacylase_ACP-bd", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-DDI-75105", "R-HSA-75105", "R-MMU-77289", "R-DME-77289", "R-DDI-199220", "R-HSA-9918487", "R-SPO-77289", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-77289", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Homologous_superfamily"}, "IPR016037": {"description": "3-dehydroquinate synthase AroB", "go_ids": ["GO:0003856", "GO:0009073", "GO:0005737"], "go_terms": ["GO:0003856:3-dehydroquinate synthase activity:F", "GO:0009073:aromatic amino acid biosynthetic process:P", "GO:0005737:cytoplasm:C"], "name": "DHQ_synth_AroB", "pathway_ids": ["PWY-6164", "R-MTU-964903"], "pathways": ["PWY-6164:t:3-dehydroquinate biosynthesis I", "R-MTU-964903:r:Chorismate via Shikimate Pathway"], "type": "Family"}, "IPR016039": {"description": "Thiolase-like", "go_ids": ["GO:0016746"], "go_terms": ["GO:0016746:acyltransferase activity:F"], "name": "Thiolase-like", "pathway_ids": ["R-RNO-1482798", "R-HSA-6798695", "R-SCE-9969896", "R-HSA-1989781", "R-DRE-77111", "R-DDI-75105", "R-CEL-77348", "R-RNO-2046106", "R-HSA-9918487", "R-MTU-9635470", "R-MMU-199220", "R-HSA-77346", "R-RNO-77305", "R-RNO-9033241", "R-MMU-77346", "R-MMU-389887", "R-RNO-77285", "R-RNO-389887", "R-MMU-9854311", "R-RNO-77289", "R-BTA-9837999", "R-SCE-9033241", "R-DDI-199220", "R-MMU-1482798", "R-BTA-1482798", "R-DRE-70895", "R-DRE-77108", "R-CEL-77346", "R-HSA-77289", "R-BTA-70895", "R-HSA-9854311", "R-CEL-9837999", "R-HSA-9915355", "R-MMU-77350", "R-RNO-77111", "R-BTA-77289", "R-SCE-390247", "R-HSA-389887", "R-HSA-70895", "R-HSA-77348", "R-CEL-77310", "R-MMU-9969896", "R-RNO-77108", "R-MMU-77348", "R-BTA-77285", "R-BTA-77305", "R-DRE-9837999", "R-RNO-9854311", "R-BTA-77350", "R-HSA-77310", "R-BTA-77346", "R-SPO-77111", "R-CEL-9854311", "R-HSA-390247", "R-HSA-75105", "R-RNO-193368", "R-SCE-77111", "R-MMU-77289", "R-CEL-77285", "R-MMU-390247", "R-MMU-6798695", "R-CEL-77108", "R-HSA-2046106", "R-SSC-77111", "R-RNO-6798695", "R-HSA-9029558", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-CEL-77350", "R-BTA-77111", "R-SCE-2046106", "R-SCE-6798695", "R-RNO-77310", "R-DDI-70895", "R-HSA-193368", "R-MMU-77111", "R-RNO-75105", "R-HSA-199220", "R-DDI-77111", "R-HSA-77350", "R-DRE-9854311", "R-HSA-77285", "R-RNO-199220", "R-CEL-77305", "R-HSA-77111", "R-BTA-77108", "R-RNO-77350", "R-MMU-70895", "R-CEL-70895", "R-CEL-1482798", "R-MMU-77310", "R-RNO-77348", "R-HSA-9837999", "R-HSA-77305", "R-HSA-9918481", "R-CEL-77111", "R-HSA-9969896", "R-SPO-9969896", "R-HSA-2426168", "R-HSA-163765", "R-DDI-9837999", "R-DDI-77108", "R-MMU-77108", "R-MMU-2046106", "R-MMU-193368", "R-BTA-9854311", "R-CEL-9969896", "R-BTA-77310", "R-MMU-9033241", "R-RNO-9837999", "R-MMU-75105", "R-HSA-1482798", "R-MMU-77285", "R-BTA-77348", "R-RNO-70895", "R-MMU-77305", "R-HSA-77108", "R-SPO-9837999", "R-SCE-9837999", "R-SSC-9837999", "R-DDI-9969896", "R-HSA-9033500", "R-HSA-9033241", "R-RNO-390247", "R-RNO-9969896"], "pathways": ["R-RNO-1482798:r:Acyl chain remodeling of CL", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-DRE-77111:r:Synthesis of Ketone Bodies", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9033241:r:Peroxisomal protein import", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-BTA-1482798:r:Acyl chain remodeling of CL", "R-DRE-70895:r:Branched-chain amino acid catabolism", "R-DRE-77108:r:Utilization of Ketone Bodies", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-9915355:r:Beta-ketothiolase deficiency", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-CEL-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-RNO-77108:r:Utilization of Ketone Bodies", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SPO-77111:r:Synthesis of Ketone Bodies", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SCE-77111:r:Synthesis of Ketone Bodies", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-CEL-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-77108:r:Utilization of Ketone Bodies", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SSC-77111:r:Synthesis of Ketone Bodies", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-CEL-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-BTA-77111:r:Synthesis of Ketone Bodies", "R-SCE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DDI-77111:r:Synthesis of Ketone Bodies", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-CEL-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-BTA-77108:r:Utilization of Ketone Bodies", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-CEL-1482798:r:Acyl chain remodeling of CL", 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kinase/diacylglycerol kinase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "NAD/diacylglycerol_kinase_sf", "pathway_ids": ["PWY-7268", "PWY-5083", "PWY-7269", "PWY-8148", "R-SPO-196807", "R-SSC-114508", "R-MMU-196807", "R-DDI-5218921", "R-MMU-9837999", "R-HSA-6802952", "R-DDI-1660661", "R-HSA-9833482", "R-DDI-9009391", "R-SCE-196807", "R-SCE-1660661", "R-SCE-9833482", "R-DDI-1483206", "R-MMU-9009391", "R-RNO-9009391", "R-DME-114508", "R-SPO-5218921", "R-CEL-9840309", "R-MMU-9833482", "R-MMU-1483206", "R-HSA-114508", "R-SPO-9009391", "R-CEL-114508", "R-SPO-390471", "R-RNO-390471", "R-HSA-9837999", "R-HSA-1483206", "R-RNO-114508", "R-SPO-1483206", "R-SCE-390471", "R-CEL-1660661", "R-MMU-5218921", "R-MMU-114508", "R-CEL-1483206", "R-DDI-9833482", "R-BTA-114508", "R-HSA-390471", "R-DDI-390471", "R-MMU-390471", "R-HSA-196807", "R-SCE-9009391", "R-CEL-9833482", "R-RNO-9837999", "R-HSA-1660661", "R-RNO-196807", "R-HSA-5218921", "R-XTR-196807", "R-RNO-5218921", "R-DRE-1483206", "R-HSA-9840309", "R-SCE-5218921", "R-HSA-9009391", "R-SPO-9833482", "R-CEL-5218921", "R-SCE-1483206", "R-MMU-9840309", "R-DDI-114508", "R-CEL-390471", "R-RNO-1660661", "R-CEL-9009391", "R-SPO-1660661", "R-RNO-9833482", "R-MMU-1660661"], "pathways": ["PWY-7268:t:cytosolic NADPH production (yeast)", "PWY-5083:t:NAD(P)/NADPH interconversion", "PWY-7269:t:mitochondrial NADPH production (yeast)", "PWY-8148:t:NADP biosynthesis", "R-SPO-196807:r:Nicotinate metabolism", "R-SSC-114508:r:Effects of PIP2 hydrolysis", "R-MMU-196807:r:Nicotinate metabolism", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-9833482:r:PKR-mediated signaling", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-SCE-196807:r:Nicotinate metabolism", "R-SCE-1660661:r:Sphingolipid de novo biosynthesis", "R-SCE-9833482:r:PKR-mediated signaling", "R-DDI-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-SPO-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-SPO-1483206:r:Glycerophospholipid biosynthesis", "R-SCE-390471:r:Association of TriC/CCT with target proteins during 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"R-SPO-426486"], "pathways": ["R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-BTA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-SPO-426486:r:Small interfering RNA (siRNA) biogenesis"], "type": "Homologous_superfamily"}, "IPR016069": {"description": "Translin, C-terminal", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "Translin_C", "pathway_ids": ["R-MMU-426486", "R-HSA-426486", "R-RNO-426486", "R-BTA-426486", "R-SPO-426486"], "pathways": ["R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-BTA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-SPO-426486:r:Small interfering RNA (siRNA) biogenesis"], "type": "Homologous_superfamily"}, "IPR016071": {"description": 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"R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-GGA-9954709", "R-BTA-9954714", "R-GGA-975957", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-MMU-5419276", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-GGA-1799339", "R-DME-975957", "R-DDI-156827", "R-DDI-9954716", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational 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"R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR016084": {"description": "Haem oxygenase-like, multi-helical", "go_ids": [], "go_terms": [], "name": "Haem_Oase-like_multi-hlx", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-MMU-9707587", "R-SSC-9707587", "R-SSC-189483", "R-MMU-9707564", "R-RNO-917937", "R-MMU-8980692", "R-RNO-8980692", "R-HSA-9660826", "R-RNO-9707564", "R-HSA-9707616", "R-SSC-9609523", "R-HSA-6785807", "R-RNO-9609523", "R-HSA-189483", "R-BTA-9609523", "R-MMU-917937", "R-MMU-189483", "R-HSA-8980692", "R-SSC-9707564", "R-BTA-9707587", "R-HSA-917937", "R-HSA-9707587", "R-HSA-9707564", "R-BTA-917937", "R-BTA-189483", "R-SSC-917937", "R-MMU-6798695", "R-MMU-9609523", "R-HSA-9609523", "R-RNO-189483", "R-RNO-9707587", "R-HSA-844456", "R-HSA-9818027", "R-BTA-9707564"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9707587:r:Regulation of HMOX1 expression and activity", "R-SSC-9707587:r:Regulation of HMOX1 expression and activity", "R-SSC-189483:r:Heme degradation", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707616:r:Heme signaling", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-189483:r:Heme degradation", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-917937:r:Iron uptake and transport", "R-MMU-189483:r:Heme degradation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SSC-9707564:r:Cytoprotection by HMOX1", "R-BTA-9707587:r:Regulation of HMOX1 expression and activity", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9707587:r:Regulation of HMOX1 expression and activity", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-BTA-917937:r:Iron uptake and transport", "R-BTA-189483:r:Heme degradation", "R-SSC-917937:r:Iron uptake and transport", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-189483:r:Heme degradation", "R-RNO-9707587:r:Regulation of HMOX1 expression and activity", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR016085": {"description": "Protease inhibitor, beta-barrel domain", "go_ids": ["GO:0004866"], "go_terms": ["GO:0004866:endopeptidase inhibitor activity:F"], "name": "Protease_inh_B-barrel_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016087": {"description": "Chalcone isomerase", "go_ids": [], "go_terms": [], "name": "Chalcone_isomerase", "pathway_ids": ["PWY-7397", "PWY-7897", "PWY-5059", "PWY-2002", "PWY-6787", "PWY-6325"], "pathways": ["PWY-7397:t:naringenin biosynthesis (engineered)", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5059:t:pinobanksin biosynthesis", "PWY-2002:t:isoflavonoid biosynthesis I", "PWY-6787:t:flavonoid biosynthesis (in equisetum)", "PWY-6325:t:echinatin biosynthesis"], "type": "Domain"}, "IPR016088": {"description": "Chalcone isomerase, 3-layer sandwich", "go_ids": [], "go_terms": [], "name": "Chalcone_isomerase_3-sand", "pathway_ids": ["PWY-7397", "PWY-7897", "PWY-5059", "PWY-2002", "PWY-6787", "PWY-6325"], "pathways": ["PWY-7397:t:naringenin biosynthesis (engineered)", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5059:t:pinobanksin biosynthesis", "PWY-2002:t:isoflavonoid biosynthesis I", "PWY-6787:t:flavonoid biosynthesis (in equisetum)", "PWY-6325:t:echinatin biosynthesis"], "type": "Homologous_superfamily"}, "IPR016089": {"description": "Chalcone isomerase, orthogonal bundle domain superfamily", "go_ids": [], "go_terms": [], "name": "Chalcone_isomerase_bundle_sf", "pathway_ids": ["PWY-7397", "PWY-7897", "PWY-5059", "PWY-2002", "PWY-6787", "PWY-6325"], "pathways": ["PWY-7397:t:naringenin biosynthesis (engineered)", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5059:t:pinobanksin biosynthesis", "PWY-2002:t:isoflavonoid biosynthesis I", "PWY-6787:t:flavonoid biosynthesis (in equisetum)", "PWY-6325:t:echinatin biosynthesis"], "type": "Homologous_superfamily"}, "IPR016090": {"description": "Phospholipase A2-like, central domain", "go_ids": ["GO:0006644", "GO:0050482", "GO:0004623"], "go_terms": ["GO:0006644:phospholipid metabolic process:P", "GO:0050482:arachidonate secretion:P", "GO:0004623:A2-type glycerophospholipase activity:F"], "name": "PLA2-like_dom", "pathway_ids": ["PWY-8411", "PWY-8051", "PWY-7783", "PWY-7416", "PWY-8398", "PWY-7417", "PWY-8400", "PWY-8399", "PWY-7409", "PWY-6803", "PWY-8395", "PWY-8356", "PWY-8357", "PWY-8355", "PWY-8396", "PWY-8413", "PWY-8397", "PWY-8053", "PWY-8412", "PWY-8410", "R-BTA-6803157", "R-RNO-1483166", "R-BTA-1482788", "R-BTA-1482801", "R-CFA-1482788", "R-CFA-1482839", "R-HSA-9925561", "R-CFA-1482922", "R-HSA-1483166", "R-HSA-1482925", "R-RNO-1482788", "R-HSA-1482922", "R-CFA-1482925", "R-CFA-1483166", "R-HSA-6803157", "R-MMU-1482788", "R-BTA-1483166", "R-RNO-1482925", "R-MMU-6803157", "R-MMU-1482925", "R-RNO-1482801", "R-RNO-1482839", "R-RNO-6803157", "R-CFA-1482801", "R-RNO-1482922", "R-BTA-1482839", "R-BTA-1482925", "R-MMU-1482839", "R-HSA-1482801", "R-MMU-1483166", "R-MMU-1482922", "R-HSA-1482839", "R-BTA-1482922", "R-MMU-1482801", "R-HSA-1482788"], "pathways": ["PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-8051:t:anandamide biosynthesis I", "PWY-7783:t:plasmalogen degradation", "PWY-7416:t:phospholipid remodeling (phosphatidylcholine, yeast)", "PWY-8398:t:alpha-linolenate metabolites biosynthesis", "PWY-7417:t:phospholipid remodeling (phosphatidate, yeast)", "PWY-8400:t:docosahexaenoate metabolites biosynthesis", "PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-7409:t:phospholipid remodeling (phosphatidylethanolamine, yeast)", "PWY-6803:t:phosphatidylcholine acyl editing", "PWY-8395:t:linoleate metabolites biosynthesis", "PWY-8356:t:maresin biosynthesis", "PWY-8357:t:protectin biosynthesis", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-8413:t:representative whole plasma EPA-derived icosanoids", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-8412:t:representative whole plasma DHA-derived 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"R-RNO-1482801:r:Acyl chain remodelling of PS", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-RNO-6803157:r:Antimicrobial peptides", "R-CFA-1482801:r:Acyl chain remodelling of PS", "R-RNO-1482922:r:Acyl chain remodelling of PI", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-MMU-1483166:r:Synthesis of PA", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Domain"}, "IPR016091": {"description": "Superantigen toxin, C-terminal", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "SuperAg_toxin_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016092": {"description": "FeS A-type 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"R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR016097": {"description": "Domain of unknown function DUF695", "go_ids": [], "go_terms": [], "name": "DUF695", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR016098": {"description": "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal", "go_ids": [], "go_terms": [], "name": "CAP/MinC_C", "pathway_ids": ["R-DDI-6798695", "R-HSA-114608", "R-SPO-6798695", "R-HSA-6798695", "R-DRE-5624138", "R-MMU-5624138", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-5624138", "R-HSA-428890", "R-HSA-389977", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR016099": {"description": "Prismane-like, alpha/beta-sandwich", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Prismane-like_a/b-sand", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016100": {"description": "Prismane, alpha-bundle", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Prismane_a-bundle", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016101": {"description": "CO dehydrogenase, alpha-bundle", "go_ids": ["GO:0006091", "GO:0016151", "GO:0051539", "GO:0043885"], "go_terms": ["GO:0006091:generation of precursor metabolites and energy:P", "GO:0016151:nickel cation binding:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0043885:anaerobic carbon-monoxide dehydrogenase activity:F"], "name": "CO_DH_a-bundle", "pathway_ids": ["PWY-5372", "PWY-6780"], "pathways": ["PWY-5372:t:carbon tetrachloride degradation II", "PWY-6780:t:hydrogen production VI"], "type": "Homologous_superfamily"}, "IPR016102": {"description": "Succinyl-CoA synthetase-like", "go_ids": [], "go_terms": [], "name": "Succinyl-CoA_synth-like", "pathway_ids": ["PWY-8354", "PWY-8347", "PWY-6728", "PWY-7384", "PWY-5690", "PWY-5537", "PWY-5538", "PWY-5392", "PWY-6969", "R-HSA-6798695", "R-HSA-163765", "R-DDI-6798695", "R-SPO-6798695", "R-MMU-9837999", "R-CEL-9837999", "R-DDI-75105", "R-BTA-71403", "R-CEL-6798695", "R-SPO-75105", "R-BTA-6798695", "R-RNO-75105", "R-MMU-75105", "R-BTA-75105", "R-SPO-71403", "R-SSC-71403", "R-CEL-71403", "R-MMU-71403", "R-BTA-9837999", "R-SCE-71403", "R-HSA-75105", "R-MMU-6798695", "R-DME-71403", "R-DDI-71403", "R-HSA-9837999", "R-RNO-71403", "R-RNO-6798695", "R-HSA-71403", "R-CEL-75105"], "pathways": ["PWY-8354:t:adipate degradation", "PWY-8347:t:adipate biosynthesis", "PWY-6728:t:methylaspartate cycle", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5537:t:pyruvate fermentation to acetate V", "PWY-5538:t:pyruvate fermentation to acetate VI", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-6798695:r:Neutrophil degranulation", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Homologous_superfamily"}, "IPR016103": {"description": "ProQ/FinO domain", "go_ids": [], "go_terms": [], "name": "ProQ/FinO", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR016104": {"description": "Pyruvoyl-dependent histidine/arginine decarboxylase", "go_ids": ["GO:0006520", "GO:0016831"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0016831:carboxy-lyase activity:F"], "name": "Pyr-dep_his/arg-deCO2ase", "pathway_ids": ["PWY-40", "PWY-43", "PWY-6834"], "pathways": ["PWY-40:t:putrescine biosynthesis I", "PWY-43:t:putrescine biosynthesis II", "PWY-6834:t:spermidine biosynthesis III"], "type": "Homologous_superfamily"}, "IPR016105": {"description": "Pyruvoyl-dependent histidine/arginine decarboxylase, 3-layer sandwich domain", "go_ids": ["GO:0006520", "GO:0016831"], "go_terms": ["GO:0006520:amino acid metabolic 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"Adenovirus_Pll_hexon_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR016110": {"description": "Adenovirus Pll, hexon, subdomain 3", "go_ids": [], "go_terms": [], "name": "Adenovirus_Pll_hexon_sub3", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016112": {"description": "Group II dsDNA virus coat/capsid protein", "go_ids": [], "go_terms": [], "name": "VP_dsDNA_II", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016115": {"description": "Bacteriophage PRD1, P3, N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_PRD1_P3_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016117": {"description": "ArgJ-like domain superfamily", "go_ids": [], "go_terms": [], "name": "ArgJ-like_dom_sf", "pathway_ids": ["PWY-5154"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Homologous_superfamily"}, "IPR016119": {"description": "Bromoperoxidase/chloroperoxidase C-terminal", "go_ids": ["GO:0004601"], "go_terms": ["GO:0004601:peroxidase activity:F"], "name": "Br/Cl_peroxidase_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016120": {"description": "Signal transduction histidine kinase, sporulation regulator SpoOB", "go_ids": ["GO:0000155", "GO:0000160", "GO:0016772"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "Sig_transdc_His_kin_SpoOB", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016122": {"description": "Sporulation initiation phosphotransferase B, C-terminal", "go_ids": [], "go_terms": [], "name": "SpoOB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR016123": {"description": "Mog1/PsbP, alpha/beta/alpha sandwich", "go_ids": [], "go_terms": [], "name": "Mog1/PsbP_a/b/a-sand", "pathway_ids": ["R-HSA-5576892"], "pathways": ["R-HSA-5576892:r:Phase 0 - rapid depolarisation"], "type": "Homologous_superfamily"}, "IPR016125": {"description": "Peptidase C15, pyroglutamyl peptidase I-like", "go_ids": [], "go_terms": [], "name": "Peptidase_C15-like", "pathway_ids": ["PWY-7942"], "pathways": ["PWY-7942:t:5-oxo-L-proline metabolism"], "type": "Family"}, "IPR016126": {"description": "Secretoglobin", "go_ids": [], "go_terms": [], "name": "Secretoglobin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016128": {"description": "Pyosin/cloacin translocation domain", "go_ids": [], "go_terms": [], "name": "Pyosin/cloacin_T_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR016133": {"description": "Insect cysteine-rich antifreeze protein", "go_ids": [], "go_terms": [], "name": "Insect_cyst_antifreeze_prot", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016135": {"description": "Ubiquitin-conjugating 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"R-DME-445989", "R-SPO-9033241", "R-HSA-5693571", "R-GGA-4655427", "R-DDI-174184", "R-DRE-4090294", "R-DME-174178", "R-DDI-9609523", "R-DRE-179409", "R-RNO-9646399", "R-BTA-5693571", "R-CEL-9020702", "R-BTA-983168", "R-MMU-5607764", "R-HSA-9700645", "R-BTA-179409", "R-DME-8951664", "R-BTA-141430", "R-DRE-8951664", "R-MMU-9639288", "R-DDI-9646399", "R-HSA-5676590", "R-HSA-4655427", "R-DME-2173789", "R-GGA-3232142", "R-HSA-174178", "R-HSA-9646399", "R-DME-176408", "R-HSA-8951664", "R-DRE-174048", "R-MMU-4570464", "R-RNO-110314", "R-CEL-5357905", "R-RNO-8866654", "R-DRE-2467813", "R-DRE-3232118", "R-SCE-3065678", "R-MMU-110314", "R-MMU-69473", "R-CEL-1234176", "R-DDI-3232118", "R-HSA-450302", "R-HSA-4570464", "R-HSA-937041", "R-BTA-110314", "R-SPO-4085377", "R-DRE-69017", "R-RNO-4090294", "R-HSA-9956593", "R-MMU-8866654", "R-MMU-176409", "R-HSA-5607761", "R-DDI-174084", "R-GGA-433871", "R-RNO-975144", "R-DRE-9793242", "R-RNO-5696395", "R-RNO-9705462", "R-BTA-5693565", "R-BTA-2173789", "R-DME-9954716", "R-XTR-4570464", "R-DDI-9020702", "R-RNO-2173795", "R-HSA-141430", "R-XTR-4551638", "R-CEL-9909505", "R-HSA-8866652", "R-RNO-9954716", "R-RNO-8866904", "R-MMU-9833482", "R-MMU-4655427", "R-DDI-2559582", "R-RNO-202424", "R-MMU-3232118", "R-GGA-5693565", "R-HSA-174490", "R-SCE-3899300", "R-CEL-9856649", "R-HSA-9609523", "R-HSA-4551638", "R-HSA-176408", "R-HSA-2173789", "R-RNO-3899300", "R-HSA-68867", "R-HSA-9629569", "R-HSA-9610379", "R-HSA-176409", "R-DME-174154", "R-HSA-975144", "R-CEL-3232118", "R-DME-179409", "R-CEL-9833482", "R-MMU-9705462", "R-HSA-9694631", "R-CEL-9793242", "R-SPO-4570464", "R-MMU-141430", "R-MMU-2871837", "R-RNO-174084", "R-RNO-445989", "R-GGA-3232118", "R-RNO-5689896", "R-MMU-9793242", "R-RNO-983168", "R-DRE-176412", "R-HSA-445989", "R-HSA-110314", "R-HSA-8853884", "R-GGA-3899300", "R-BTA-8951664", "R-SPO-176408", "R-GGA-3108214", "R-DRE-4615885", "R-RNO-9909505", "R-HSA-936440", "R-GGA-4551638", "R-HSA-2559582", "R-HSA-1169408", "R-HSA-174184", "R-CEL-5205685", "R-MMU-174048", "R-HSA-9909505", "R-MMU-4615885", "R-GGA-9793242", "R-DRE-8866654", "R-BTA-2467813", "R-CEL-936440", "R-HSA-9954709", "R-SPO-983168", "R-HSA-9833110", "R-BTA-5696395", "R-HSA-5656169", "R-BTA-168638", "R-HSA-5607764", "R-HSA-9918481", "R-MMU-3065678", "R-DDI-1169408", "R-SPO-3108214", "R-DRE-5693565", "R-BTA-5689896", "R-CEL-9954709", "R-DME-9033241", "R-BTA-174048", "R-DRE-4755510", "R-DRE-174084", "R-RNO-4755510", "R-MMU-176407", "R-RNO-4655427", "R-DDI-983168", "R-XTR-196791", "R-DDI-9909505", "R-DME-5205685", "R-BTA-450302", "R-SPO-9609523", "R-HSA-9705462", "R-MMU-983168", "R-DDI-174178", "R-DDI-9954716", "R-DME-68867", "R-XTR-4085377", "R-HSA-162588", "R-MMU-1234176", "R-HSA-8866654", "R-HSA-3232142", "R-CEL-4090294", "R-RNO-176408", "R-RNO-4570464", "R-MMU-5357905", "R-BTA-69017", "R-RNO-9954709", "R-DME-176409", "R-HSA-3232118", "R-RNO-3232142", "R-HSA-179409", "R-HSA-9918476", "R-MMU-3108214", "R-XTR-3108214", "R-GGA-5693607", "R-HSA-174154", "R-RNO-1234176", "R-DRE-5693607", "R-DME-202424", "R-DDI-5696395", "R-MMU-3232142", "R-MMU-450302", "R-HSA-9735871", "R-DRE-3065678", "R-HSA-201451", "R-RNO-174178", "R-SPO-9615933", "R-RNO-450321", "R-MMU-174178", "R-DRE-4570464", "R-DRE-983168", "R-MMU-5693565", "R-BTA-2871837", "R-XTR-5696395", "R-DME-174084", "R-HSA-196791", "R-BTA-174154", "R-DRE-176407", "R-DDI-176409", "R-HSA-2173795", "R-BTA-445989", "R-CEL-3108214", "R-MMU-201451", "R-DDI-917729", "R-HSA-4615885", "R-BTA-176407", "R-RNO-937041", "R-DRE-174178", "R-DDI-9833482", "R-MMU-2173789", "R-MMU-3899300", "R-DDI-936440", "R-SPO-4551638", "R-MMU-5675482", "R-MMU-5656169", "R-DME-174184", "R-DME-2173795", "R-CEL-201451", "R-MMU-176412", "R-MMU-5676590", "R-MMU-6783310", "R-GGA-196791", "R-MMU-174184", "R-MMU-9629569", "R-RNO-68867", "R-GGA-4085377", "R-BTA-9954709", "R-DME-9020702", "R-HSA-9856649", "R-RNO-69017", "R-MMU-937041", "R-BTA-5357905", "R-RNO-9833482", "R-HSA-937039", "R-CEL-8951664", "R-RNO-3065678", "R-HSA-9725370", "R-MMU-9856649", "R-SCE-9615933", "R-XTR-4615885", "R-GGA-8866654", "R-RNO-9020702", "R-RNO-2559582", "R-DRE-141430", "R-DRE-3232142", "R-HSA-5689896", "R-HSA-8866904", "R-MMU-2467813", "R-HSA-3065678", "R-HSA-9932298", "R-BTA-202424", "R-DRE-4551638", "R-RNO-5357905", "R-RNO-3108214", "R-MMU-5205685", "R-DDI-4551638", "R-BTA-176409", "R-DDI-8951664", "R-SPO-3065678", "R-HSA-450321", "R-MMU-8951664", "R-BTA-9033241", "R-SPO-5696395", "R-MMU-9954716", "R-MMU-5696395", "R-HSA-5693607", "R-MMU-445989", "R-RNO-174154", "R-RNO-3232118", "R-GGA-4615885", "R-BTA-5675482", "R-BTA-937041", "R-CEL-4551638", "R-BTA-5693607", "R-HSA-5205685", "R-CEL-9954716", "R-RNO-141430", "R-CEL-2173795", "R-CEL-8866904", "R-SPO-2559582", "R-RNO-5205685", "R-BTA-174084", "R-HSA-9687136", "R-BTA-2559582", "R-HSA-9683610", "R-HSA-9918432", "R-HSA-5675482", "R-RNO-5693607", "R-DRE-8866904", "R-SPO-179409", "R-DDI-174048", "R-RNO-69473", "R-RNO-174184", "R-RNO-196791", "R-BTA-8866652", "R-DDI-141430", "R-RNO-450302", "R-MMU-196791", "R-DME-209447", "R-BTA-176408", "R-RNO-168638", "R-HSA-975110", "R-RNO-2467813", "R-BTA-9646399", "R-DME-5607764", "R-BTA-1169408", "R-BTA-937039", "R-DRE-176409", "R-MMU-5693571", "R-DME-2871837", "R-CEL-5689896", "R-DDI-8866654", "R-CEL-4570464", "R-DDI-8866652", "R-SPO-3232118", "R-DDI-176408", "R-DME-9954709", "R-BTA-69473", "R-HSA-3108214", "R-DRE-4655427", "R-HSA-977225", "R-SCE-9856649", "R-DDI-9615933", "R-DDI-9793242", "R-HSA-1221632", "R-MMU-9954709", "R-RNO-176407", "R-CEL-9646399", "R-DRE-6783310", "R-HSA-2871837", "R-MMU-4085377", "R-DRE-5696395", "R-MMU-937039", "R-CEL-3232142", "R-DDI-9954709", "R-MMU-9609523", "R-RNO-201451", "R-HSA-174084", "R-SCE-983168", "R-MMU-168638", "R-HSA-176407", "R-BTA-174178", "R-RNO-937039", "R-DDI-69017", "R-CEL-4615885", "R-DME-975144"], "pathways": ["R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-GGA-69473:r:G2/M DNA damage checkpoint", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SCE-9793242:r:SUMOylation of nuclear envelope proteins", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-XTR-3899300:r:SUMOylation of transcription cofactors", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SCE-4551638:r:SUMOylation of chromatin organization proteins", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DDI-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-HSA-9793242:r:SUMOylation of nuclear envelope proteins", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-DDI-4085377:r:SUMOylation of SUMOylation proteins", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-SPO-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-202424:r:Downstream TCR signaling", "R-DRE-68867:r:Assembly of the pre-replicative complex", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9833482:r:PKR-mediated signaling", "R-DRE-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-9020702:r:Interleukin-1 signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-4085377:r:SUMOylation of SUMOylation proteins", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-SCE-9033241:r:Peroxisomal protein import", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-SCE-9646399:r:Aggrephagy", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-GGA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-9033241:r:Peroxisomal protein import", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-DRE-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-GGA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-176412:r:Phosphorylation of the APC/C", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-CEL-4085377:r:SUMOylation of SUMOylation proteins", "R-DME-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DDI-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DDI-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9646399:r:Aggrephagy", "R-GGA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-DRE-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-8951664:r:Neddylation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-GGA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-DME-201451:r:Signaling by BMP", "R-DDI-3899300:r:SUMOylation of transcription cofactors", "R-DDI-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-SCE-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-4090294:r:SUMOylation of intracellular receptors", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-BTA-201451:r:Signaling by BMP", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-GGA-8951664:r:Neddylation", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-DRE-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-GGA-4755510:r:SUMOylation of immune response proteins", "R-DRE-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-9793242:r:SUMOylation of nuclear envelope proteins", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-DRE-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-XTR-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9615710:r:Late endosomal microautophagy", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-XTR-4090294:r:SUMOylation of intracellular receptors", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-XTR-3232118:r:SUMOylation of transcription factors", "R-DME-176412:r:Phosphorylation of the APC/C", "R-DME-9646399:r:Aggrephagy", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-4655427:r:SUMOylation of DNA methylation proteins", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DRE-4090294:r:SUMOylation of intracellular receptors", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DRE-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-9646399:r:Aggrephagy", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-CEL-9020702:r:Interleukin-1 signaling", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", 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"R-SPO-418594:r:G alpha (i) signalling events", "R-DRE-416476:r:G alpha (q) signalling events", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-418555:r:G alpha (s) signalling events", "R-CEL-4641257:r:Degradation of AXIN"], "type": "Domain"}, "IPR016138": {"description": "Ribosome-inactivating protein, subdomain 1", "go_ids": ["GO:0017148", "GO:0030598"], "go_terms": ["GO:0017148:negative regulation of translation:P", "GO:0030598:rRNA N-glycosylase activity:F"], "name": "Ribosome_inactivat_prot_sub1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016139": {"description": "Ribosome-inactivating protein, subdomain 2", "go_ids": [], "go_terms": [], "name": "Ribosome_inactivat_prot_sub2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016140": {"description": "Bifunctional inhibitor/plant lipid transfer protein/seed storage helical 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TCA cycle", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-75105:r:Fatty acyl-CoA biosynthesis"], "type": 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["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "type": "Homologous_superfamily"}, "IPR016152": {"description": "Phosphotransferase/anion transporter", "go_ids": [], "go_terms": [], "name": "PTrfase/Anion_transptr", "pathway_ids": ["R-HSA-9013405", "R-MMU-9035034", "R-HSA-9925563", "R-MMU-1237044", "R-HSA-425381", "R-BTA-425381", "R-MMU-9013407", "R-HSA-1247673", "R-RNO-1237044", "R-RNO-1247673", "R-MMU-425381", "R-DRE-425381", "R-RNO-9035034", "R-MMU-1247673", "R-RNO-9013407", "R-HSA-5619054", "R-HSA-1237044", "R-HSA-5619050", "R-MMU-9013406", "R-HSA-9035034", "R-RNO-9013406", "R-HSA-9013406", "R-HSA-9013409", "R-RNO-425381", "R-HSA-9013407"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", 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"R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-RNO-5362517:r:Signaling by Retinoic Acid", "R-DDI-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-SPO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-CEL-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-HSA-1222541:r:Cell redox homeostasis", "R-DDI-6783984:r:Glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-RNO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-MMU-6783984:r:Glycine degradation", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SCE-6783984:r:Glycine degradation", "R-CEL-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-RNO-6783984:r:Glycine degradation", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-DME-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-RNO-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SCE-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-6783984:r:Glycine degradation", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Homologous_superfamily"}, "IPR016158": {"description": "Cullin homology domain", "go_ids": [], "go_terms": [], "name": "Cullin_homology", "pathway_ids": ["R-XTR-983168", "R-SPO-5696400", "R-XTR-9755511", "R-RNO-5658442", "R-HSA-917937", "R-HSA-9705462", "R-HSA-69017", "R-MMU-983168", "R-SPO-6782135", "R-HSA-202424", "R-DDI-174154", "R-HSA-9020702", "R-HSA-174178", "R-HSA-9013418", "R-HSA-9604323", "R-RNO-9013422", "R-CEL-5632684", "R-HSA-8951664", "R-MMU-174154", "R-HSA-9010553", "R-MMU-69017", "R-CEL-195253", "R-MMU-9020702", "R-DDI-6782210", "R-MMU-9706019", "R-HSA-69231", "R-RNO-8863795", "R-DDI-179409", "R-MMU-110314", 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early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-CEL-69231:r:Cyclin D associated events in G1", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-176409:r:APC/C:Cdc20 mediated 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"R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-SCE-917937:r:Iron uptake and transport", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-68949:r:Orc1 removal from chromatin", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation 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"R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-RNO-9696270:r:RND2 GTPase cycle", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-RNO-70350:r:Fructose catabolism", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-71262:r:Carnitine synthesis", "R-MMU-71262:r:Carnitine synthesis", "R-BTA-71384:r:Ethanol oxidation", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-MMU-380612:r:Metabolism of serotonin", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-211945:r:Phase I - Functionalization of compounds", "R-SCE-380612:r:Metabolism of serotonin", "R-MMU-71064:r:Lysine catabolism", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-SPO-70350:r:Fructose catabolism", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-9845614:r:Sphingolipid catabolism", "R-RNO-70688:r:Proline catabolism", "R-RNO-71064:r:Lysine catabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-RNO-916853:r:Degradation of GABA", "R-HSA-916853:r:Degradation of GABA", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DRE-6798163:r:Choline catabolism", "R-RNO-196757:r:Metabolism of folate and pterines", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-380612:r:Metabolism of serotonin", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-71384:r:Ethanol oxidation"], "type": "Homologous_superfamily"}, "IPR016164": {"description": "FAD-linked oxidase-like, C-terminal", "go_ids": ["GO:0003824", "GO:0050660"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "FAD-linked_Oxase-like_C", "pathway_ids": ["R-MMU-9837999", "R-DRE-880009", "R-DRE-1268020", "R-DME-9033241", "R-CEL-75896", "R-RNO-75896", "R-MMU-9033241", "R-SCE-880009", "R-MMU-75896", "R-DRE-9837999", "R-SPO-880009", "R-RNO-9033241", "R-HSA-880009", "R-MMU-880009", "R-HSA-1268020", "R-HSA-75896", "R-SCE-9837999", "R-BTA-880009", "R-MMU-1268020", "R-HSA-9837999", "R-HSA-9033500", "R-HSA-9033241", "R-RNO-880009", "R-DME-75896"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-DRE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DRE-1268020:r:Mitochondrial protein import", "R-DME-9033241:r:Peroxisomal protein import", "R-CEL-75896:r:Plasmalogen biosynthesis", "R-RNO-75896:r:Plasmalogen biosynthesis", "R-MMU-9033241:r:Peroxisomal protein import", "R-SCE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-75896:r:Plasmalogen biosynthesis", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-SPO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-75896:r:Plasmalogen biosynthesis", "R-SCE-9837999:r:Mitochondrial protein 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"R-DRE-880009", "R-GGA-421178", "R-MMU-9033241", "R-MMU-8851680", "R-SPO-880009", "R-HSA-9748787", "R-HSA-880009", "R-MMU-880009", "R-RNO-964975", "R-MMU-74259", "R-DDI-964975", "R-HSA-9033500", "R-HSA-9033241", "R-RNO-880009", "R-DDI-74259"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-75896:r:Plasmalogen biosynthesis", "R-RNO-75896:r:Plasmalogen biosynthesis", "R-SCE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-75896:r:Plasmalogen biosynthesis", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-74259:r:Purine catabolism", "R-HSA-1268020:r:Mitochondrial protein import", "R-DME-74259:r:Purine catabolism", "R-HSA-75896:r:Plasmalogen biosynthesis", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9748787:r:Azathioprine ADME", "R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-DRE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-GGA-421178:r:Urate synthesis", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-SPO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-9748787:r:Azathioprine 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"R-RNO-75896:r:Plasmalogen biosynthesis", "R-MMU-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-SCE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-75896:r:Plasmalogen biosynthesis", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-HSA-74259:r:Purine catabolism", "R-HSA-1268020:r:Mitochondrial protein import", "R-DME-74259:r:Purine catabolism", "R-HSA-75896:r:Plasmalogen biosynthesis", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9748787:r:Azathioprine ADME", "R-MMU-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-DME-75896:r:Plasmalogen biosynthesis", "R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-DRE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-DRE-1268020:r:Mitochondrial protein import", "R-RNO-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-DME-9033241:r:Peroxisomal protein import", "R-GGA-421178:r:Urate synthesis", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-RNO-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-CEL-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-SPO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DDI-74259:r:Purine catabolism", "R-CEL-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "type": "Homologous_superfamily"}, "IPR016170": {"description": "Cytokinin dehydrogenase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Cytok_DH_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR016171": {"description": "Vanillyl-alcohol oxidase, C-terminal subdomain 2", "go_ids": [], "go_terms": [], "name": "Vanillyl_alc_oxidase_C-sub2", "pathway_ids": ["R-MMU-9837999", "R-DRE-880009", "R-DRE-1268020", "R-DME-9033241", "R-CEL-75896", "R-RNO-75896", "R-MMU-9033241", "R-SCE-880009", "R-MMU-75896", "R-DRE-9837999", "R-SPO-880009", "R-RNO-9033241", "R-HSA-880009", "R-MMU-880009", "R-HSA-1268020", "R-HSA-75896", "R-SCE-9837999", "R-BTA-880009", "R-MMU-1268020", "R-HSA-9837999", "R-HSA-9033500", "R-HSA-9033241", "R-RNO-880009", "R-DME-75896"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-DRE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DRE-1268020:r:Mitochondrial protein import", "R-DME-9033241:r:Peroxisomal protein import", "R-CEL-75896:r:Plasmalogen biosynthesis", "R-RNO-75896:r:Plasmalogen biosynthesis", "R-MMU-9033241:r:Peroxisomal protein import", "R-SCE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-75896:r:Plasmalogen biosynthesis", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-SPO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-75896:r:Plasmalogen biosynthesis", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DME-75896:r:Plasmalogen biosynthesis"], "type": "Homologous_superfamily"}, "IPR016172": {"description": "D-lactate dehydrogenase, cap domain, subdomain 1", "go_ids": ["GO:0006089", "GO:0050660", "GO:0055085"], "go_terms": ["GO:0006089:lactate metabolic process:P", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0055085:transmembrane transport:P"], "name": "D-lactate_DH_C-sub1", "pathway_ids": ["PWY-5386", "PWY-7425"], "pathways": ["PWY-5386:t:methylglyoxal degradation I", "PWY-7425:t:2-chloroacrylate degradation I"], "type": "Homologous_superfamily"}, "IPR016173": {"description": "D-lactate dehydrogenase, cap domain, subdomain 2", "go_ids": ["GO:0006089", "GO:0050660", "GO:0055085"], "go_terms": ["GO:0006089:lactate metabolic process:P", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0055085:transmembrane transport:P"], "name": "D-lactate_DH_C-sub2", "pathway_ids": ["PWY-5386", "PWY-7425"], "pathways": ["PWY-5386:t:methylglyoxal degradation I", "PWY-7425:t:2-chloroacrylate degradation I"], "type": "Homologous_superfamily"}, "IPR016174": {"description": "Di-haem cytochrome, transmembrane", "go_ids": ["GO:0016020", "GO:0022904"], "go_terms": ["GO:0016020:membrane:C", "GO:0022904:respiratory electron transport chain:P"], "name": "Di-haem_cyt_TM", "pathway_ids": ["R-HSA-9865881", "R-HSA-5419276", "R-DDI-611105", "R-DRE-611105", "R-DRE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-RNO-5419276", "R-CEL-611105", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-BTA-9865881", "R-RNO-9865881", "R-SPO-611105", "R-CEL-5419276", "R-SCE-611105", "R-DRE-5419276", "R-BTA-611105", "R-DME-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DDI-611105:r:Respiratory electron transport", "R-DRE-611105:r:Respiratory electron transport", "R-DRE-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-5419276:r:Mitochondrial translation termination", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-BTA-9865881:r:Complex III assembly", "R-RNO-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-CEL-5419276:r:Mitochondrial translation termination", "R-SCE-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR016176": {"description": "Cobalamin (vitamin B12)-dependent enzyme, catalytic", "go_ids": ["GO:0003824", "GO:0031419"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0031419:cobalamin binding:F"], "name": "Cbl-dep_enz_cat", "pathway_ids": ["R-HSA-3359475", "R-HSA-9759218", "R-MMU-71032", "R-HSA-3359478", "R-CEL-71032", "R-CEL-9759218", "R-HSA-71032", "R-MMU-9759218"], "pathways": ["R-HSA-3359475:r:Defective MMAA causes MMA, cblA type", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-3359478:r:Defective MUT causes MMAM", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism"], "type": "Homologous_superfamily"}, "IPR016177": {"description": "DNA-binding domain superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "DNA-bd_dom_sf", "pathway_ids": ["R-HSA-9022702", "R-HSA-73728", "R-MMU-73762", "R-HSA-110357", "R-HSA-9022692", "R-HSA-427413", "R-MMU-3214815", "R-HSA-9022538", "R-HSA-6804758", "R-HSA-9022535", "R-HSA-9844594", "R-HSA-3214841", "R-HSA-9845323", "R-HSA-9843970", "R-DME-3214841", "R-HSA-8943724", "R-MMU-9022692", "R-HSA-110329", "R-MMU-110329", "R-MMU-5689603", "R-MMU-110357", "R-DME-6804759", "R-HSA-9022707", "R-MMU-3214841", "R-MMU-9843940", "R-DRE-9843940", "R-DME-9772755", "R-MMU-3899300", "R-RNO-9022692", "R-DRE-9843970", "R-HSA-9022537", "R-HSA-110328", "R-HSA-9022534", "R-HSA-3214815", "R-CEL-3214841", "R-HSA-9679191", "R-HSA-73762", "R-MMU-8943724", "R-HSA-9725371", "R-HSA-9022927", "R-DRE-3214841", "R-DME-3214847", "R-DME-9843940", "R-MMU-6804758", "R-HSA-9022699", "R-HSA-427389", "R-HSA-9843940", "R-HSA-8986944", "R-HSA-5689603", "R-HSA-3899300"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of 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"R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9022534:r:Loss of MECP2 binding ability to 5hmC-DNA", "R-HSA-3214815:r:HDACs deacetylate histones", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9022927:r:MECP2 regulates transcription of genes involved in GABA signaling", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-DME-3214847:r:HATs acetylate histones", "R-DME-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-5689603:r:UCH proteinases", "R-HSA-3899300:r:SUMOylation of transcription cofactors"], "type": "Homologous_superfamily"}, "IPR016179": {"description": "Insulin-like", "go_ids": ["GO:0005179", "GO:0005576"], "go_terms": ["GO:0005179:hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Insulin-like", "pathway_ids": ["R-DRE-74749", "R-MMU-6811558", "R-HSA-77387", "R-HSA-264876", "R-RNO-74752", "R-RNO-2428933", "R-MMU-74752", "R-GGA-422085", "R-CFA-77387", "R-RNO-74749", "R-CFA-2428933", "R-CFA-74752", "R-DRE-74713", "R-CFA-114608", "R-SSC-6811558", "R-MMU-422085", "R-RNO-6811558", "R-MMU-381426", "R-DRE-6807878", "R-CFA-74749", "R-MMU-74751", "R-SSC-2428928", "R-RNO-422085", "R-SSC-74752", "R-HSA-381426", "R-MMU-2428933", "R-RNO-2404192", "R-MMU-77387", "R-HSA-2404192", "R-SSC-74749", "R-HSA-74713", "R-SSC-381426", "R-SSC-2428933", 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(IGF1R)", "R-SSC-74749:r:Signal attenuation", "R-HSA-74713:r:IRS activation", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-2428933:r:SHC-related events triggered by IGF1R", "R-SSC-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-418555:r:G alpha (s) signalling events", "R-DRE-74752:r:Signaling by Insulin receptor", "R-GGA-77387:r:Insulin receptor recycling", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-77387:r:Insulin receptor recycling", "R-CFA-74713:r:IRS activation", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-110478:r:Insulin signaling pathway", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-BTA-418555:r:G alpha (s) signalling events", "R-MMU-264876:r:Insulin processing", "R-DRE-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-DRE-77387:r:Insulin receptor recycling", "R-GGA-74749:r:Signal attenuation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-MMU-114608:r:Platelet degranulation", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-RNO-264876:r:Insulin processing", "R-CFA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-CFA-74751:r:Insulin receptor signalling cascade", "R-GGA-264876:r:Insulin processing", "R-HSA-977225:r:Amyloid fiber formation", "R-SSC-114608:r:Platelet degranulation", "R-BTA-2428928:r:IRS-related events triggered by IGF1R", "R-CFA-264876:r:Insulin processing", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-GGA-74713:r:IRS activation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-MMU-444821:r:Relaxin receptors", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-SSC-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SSC-264876:r:Insulin processing", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-444821:r:Relaxin receptors", "R-CFA-6807878:r:COPI-mediated anterograde transport", "R-GGA-74751:r:Insulin receptor signalling cascade", "R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor 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receptor", "R-SSC-74713:r:IRS activation", "R-GGA-74752:r:Signaling by Insulin receptor", "R-CFA-444821:r:Relaxin receptors", "R-DRE-264876:r:Insulin processing", "R-SSC-418594:r:G alpha (i) signalling events", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-74751:r:Insulin receptor signalling cascade", "R-MMU-74749:r:Signal attenuation", "R-RNO-444821:r:Relaxin receptors", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR016181": {"description": "Acyl-CoA N-acyltransferase", "go_ids": [], "go_terms": [], "name": "Acyl_CoA_acyltransferase", "pathway_ids": ["R-DRE-70635", "R-CEL-446210", "R-HSA-5689880", "R-HSA-8936459", "R-RNO-5693565", "R-SCE-3214847", "R-MMU-6804756", "R-MMU-351200", "R-BTA-2514859", "R-HSA-5693565", "R-RNO-9018519", "R-MMU-5685938", "R-BTA-351200", "R-HSA-203615", "R-MMU-69473", "R-MMU-5689880", "R-HSA-209931", "R-DME-351202", "R-HSA-2122947", "R-DRE-351202", "R-SCE-2468052", 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catabolism", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-CEL-196780:r:Biotin transport and metabolism", "R-MMU-70268:r:Pyruvate metabolism", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-70635:r:Urea cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-RNO-70635:r:Urea cycle", "R-HSA-70268:r:Pyruvate metabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-CEL-70263:r:Gluconeogenesis", "R-HSA-200425:r:Carnitine shuttle", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-70263:r:Gluconeogenesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-70635:r:Urea cycle", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR016186": {"description": "C-type lectin-like/link domain superfamily", "go_ids": [], "go_terms": [], "name": "C-type_lectin-like/link_sf", "pathway_ids": ["R-RNO-2022923", "R-HSA-8851680", "R-MMU-114604", "R-HSA-3000178", "R-HSA-3560783", "R-RNO-1474228", "R-HSA-9918485", "R-RNO-2142845", "R-SSC-202733", "R-DME-1482788", "R-DME-6803157", "R-MMU-166662", "R-GGA-2132270", "R-BTA-8957275", "R-BTA-2142845", "R-MMU-9707616", "R-MMU-202733", "R-HSA-8948216", "R-MMU-1482788", "R-HSA-166663", "R-CEL-1482801", "R-HSA-114604", "R-RNO-5686938", "R-HSA-1474228", "R-BTA-1971475", "R-SSC-2022854", 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"R-MMU-2022090", "R-MMU-140875", "R-HSA-1482801", "R-MMU-2022857", "R-MMU-8851680", "R-DME-1482922", "R-DME-1474228", "R-MMU-1650814", "R-HSA-877300", "R-HSA-166662", "R-RNO-2022854", "R-BTA-5683826", "R-BTA-1482922", "R-RNO-166016", "R-HSA-5687868", "R-HSA-202733", "R-HSA-5688849", "R-HSA-391160", "R-HSA-3595174", "R-HSA-6798695", "R-CFA-2424491", "R-HSA-9920588", "R-MMU-5607764", "R-HSA-166016", "R-CEL-6798695", "R-RNO-5621480", "R-BTA-1482801", "R-BTA-6798695", "R-SSC-5686938", "R-HSA-9927418", "R-SSC-1474228", "R-MMU-8957275", "R-HSA-1650814", "R-DME-9749641", "R-HSA-2142845", "R-MMU-3000178", "R-RNO-202733", "R-MMU-381426", "R-HSA-6803157", "R-BTA-2022870", "R-BTA-391160", "R-HSA-5621480", "R-RNO-3000178", "R-DME-1482925", "R-HSA-6783783", "R-HSA-381426", "R-MMU-2022923", "R-MMU-446203", "R-MMU-1474228", "R-SSC-3000178", "R-HSA-2024101", "R-RNO-6803157", "R-BTA-198933", "R-MMU-5620916", "R-DRE-3000480", "R-RNO-198933", "R-MMU-5621575", "R-MMU-166016", "R-HSA-2172127", "R-CEL-1482839", "R-RNO-446203", "R-SSC-166016", "R-BTA-1482925", "R-HSA-6785807", "R-MMU-2160916", "R-MMU-2142845", "R-MMU-2022854", "R-BTA-166016", "R-HSA-3560801", "R-RNO-381426", "R-MMU-198933", "R-HSA-2022854", "R-HSA-5688890", "R-HSA-5683826", "R-SSC-391160", "R-HSA-3656243", "R-HSA-4420332", "R-MMU-6798695", "R-HSA-198933", "R-MMU-416700", "R-MMU-114608", "R-GGA-2132263", "R-MMU-2022870", "R-BTA-6803157", "R-HSA-3000157", "R-MMU-8948216", "R-BTA-1482788", "R-DME-1482839", "R-RNO-166662", "R-BTA-3000178", "R-MMU-3000497", "R-HSA-9925561", "R-MMU-3000480", "R-SSC-5683826", "R-RNO-114608", "R-BTA-202733", "R-CEL-6803157", "R-HSA-1482922", "R-HSA-416700", "R-RNO-8957275", "R-RNO-2024101", "R-HSA-5621575", "R-BTA-381426", "R-BTA-2160916", "R-HSA-9833110", "R-HSA-9938206", "R-MMU-1482925", "R-HSA-5607764", "R-BTA-2024101", "R-RNO-1236978", "R-MMU-5683826", "R-HSA-216083", "R-HSA-446203", "R-CEL-9619665", "R-CEL-1482925", "R-HSA-9927432", "R-HSA-1236978", "R-CEL-1483166", "R-HSA-1592389", "R-RNO-5683826", "R-HSA-2160916", "R-BTA-5686938", "R-DME-1482801", "R-RNO-1971475", "R-MMU-1482922", "R-RNO-2424491", "R-HSA-9692916", "R-BTA-5621480", "R-MMU-2424491", "R-HSA-8957275", "R-BTA-2022923", "R-HSA-2197563", "R-CEL-1482788", "R-MMU-1236978", "R-MMU-1971475", "R-MMU-1442490", "R-MMU-1482801", "R-HSA-9637628"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-2142845:r:Hyaluronan metabolism", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-DME-1482788:r:Acyl chain remodelling of PC", "R-DME-6803157:r:Antimicrobial peptides", "R-MMU-166662:r:Lectin pathway of complement activation", "R-GGA-2132270:r:Lectin-mediated initiation of complement cascade", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2142845:r:Hyaluronan metabolism", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-8948216:r:Collagen chain trimerization", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-HSA-166663:r:Initial triggering of complement", "R-CEL-1482801:r:Acyl chain remodelling of PS", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-CEL-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-210991:r:Basigin interactions", "R-HSA-2424491:r:DAP12 signaling", "R-SSC-2022857:r:Keratan sulfate degradation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-2022857:r:Keratan sulfate degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-2024101:r:CS/DS degradation", "R-CEL-1482922:r:Acyl chain remodelling of PI", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-166662:r:Lectin pathway of complement activation", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-CFA-2172127:r:DAP12 interactions", "R-GGA-3000178:r:ECM proteoglycans", "R-RNO-2172127:r:DAP12 interactions", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-216083:r:Integrin cell surface interactions", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-BTA-3000480:r:Scavenging by Class A Receptors", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-HSA-1483166:r:Synthesis of PA", "R-MMU-2172127:r:DAP12 interactions", "R-HSA-373760:r:L1CAM interactions", "R-DME-1483166:r:Synthesis of PA", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-HSA-114608:r:Platelet degranulation", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-BTA-1483166:r:Synthesis of PA", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-MMU-5621480:r:Dectin-2 family", "R-HSA-1442490:r:Collagen degradation", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-DRE-166662:r:Lectin pathway of complement activation", "R-HSA-9707616:r:Heme signaling", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-MMU-2022857:r:Keratan sulfate degradation", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-DME-1482922:r:Acyl chain remodelling of PI", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-166662:r:Lectin pathway of complement activation", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-BTA-5683826:r:Surfactant metabolism", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-5687868:r:Defective SFTPA2 causes IPF", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-HSA-6798695:r:Neutrophil degranulation", "R-CFA-2424491:r:DAP12 signaling", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-6798695:r:Neutrophil degranulation", "R-RNO-5621480:r:Dectin-2 family", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DME-9749641:r:Aspirin ADME", "R-HSA-2142845:r:Hyaluronan metabolism", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-HSA-5621480:r:Dectin-2 family", "R-RNO-3000178:r:ECM proteoglycans", "R-DME-1482925:r:Acyl chain remodelling of PG", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-SSC-3000178:r:ECM proteoglycans", "R-HSA-2024101:r:CS/DS degradation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-3000480:r:Scavenging by Class A Receptors", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-2172127:r:DAP12 interactions", "R-CEL-1482839:r:Acyl chain remodelling of PE", "R-RNO-446203:r:Asparagine N-linked glycosylation", "R-SSC-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-114608:r:Platelet degranulation", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-BTA-6803157:r:Antimicrobial peptides", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-DME-1482839:r:Acyl chain remodelling of PE", "R-RNO-166662:r:Lectin pathway of complement activation", "R-BTA-3000178:r:ECM proteoglycans", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-SSC-5683826:r:Surfactant metabolism", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-CEL-6803157:r:Antimicrobial peptides", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-2160916:r:Hyaluronan degradation", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-1482925:r:Acyl chain remodelling of PG", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-1483166:r:Synthesis of PA", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-5683826:r:Surfactant metabolism", "R-HSA-2160916:r:Hyaluronan degradation", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-1482801:r:Acyl chain remodelling of PS", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-5621480:r:Dectin-2 family", "R-MMU-2424491:r:DAP12 signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-CEL-1482788:r:Acyl chain remodelling of PC", 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"R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-CEL-2214320:r:Anchoring fibril formation", "R-HSA-2424491:r:DAP12 signaling", "R-DME-210991:r:Basigin interactions", "R-SSC-2022857:r:Keratan sulfate degradation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-DME-8948216:r:Collagen chain trimerization", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-2022857:r:Keratan sulfate degradation", "R-DME-216083:r:Integrin cell surface interactions", "R-RNO-2160916:r:Hyaluronan degradation", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-2024101:r:CS/DS degradation", "R-CEL-1482922:r:Acyl chain remodelling of PI", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-166662:r:Lectin pathway of complement activation", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-CFA-2172127:r:DAP12 interactions", "R-GGA-3000178:r:ECM proteoglycans", "R-RNO-2172127:r:DAP12 interactions", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-216083:r:Integrin cell surface interactions", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-HSA-1663150:r:The 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"R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-HSA-5621480:r:Dectin-2 family", "R-RNO-3000178:r:ECM proteoglycans", "R-DME-1482925:r:Acyl chain remodelling of PG", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-CEL-3000157:r:Laminin interactions", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-SSC-3000178:r:ECM proteoglycans", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-2024101:r:CS/DS degradation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-3000480:r:Scavenging by Class A Receptors", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-2172127:r:DAP12 interactions", "R-CEL-1482839:r:Acyl chain remodelling of PE", "R-RNO-446203:r:Asparagine N-linked glycosylation", "R-SSC-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-CEL-8948216:r:Collagen chain trimerization", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-416700:r:Other semaphorin interactions", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-CEL-419037:r:NCAM1 interactions", "R-MMU-419037:r:NCAM1 interactions", "R-MMU-114608:r:Platelet degranulation", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-BTA-6803157:r:Antimicrobial peptides", "R-DME-419037:r:NCAM1 interactions", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-DME-1482839:r:Acyl chain remodelling of PE", "R-BTA-1442490:r:Collagen degradation", "R-RNO-166662:r:Lectin pathway of complement activation", "R-CEL-1566977:r:Fibronectin matrix formation", "R-BTA-3000178:r:ECM proteoglycans", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-1663150:r:The activation of arylsulfatases", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-CEL-6803157:r:Antimicrobial peptides", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024101:r:CS/DS degradation", "R-BTA-3000171:r:Non-integrin membrane-ECM interactions", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-186797:r:Signaling by PDGF", "R-BTA-2160916:r:Hyaluronan degradation", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-2214320:r:Anchoring fibril formation", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-1482925:r:Acyl chain remodelling of PG", "R-BTA-1566977:r:Fibronectin matrix formation", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-1483166:r:Synthesis of PA", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-5683826:r:Surfactant metabolism", "R-HSA-2160916:r:Hyaluronan degradation", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-DME-1482801:r:Acyl chain remodelling of PS", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-BTA-5621480:r:Dectin-2 family", "R-MMU-2424491:r:DAP12 signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-CEL-1482788:r:Acyl chain remodelling of PC", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-1442490:r:Collagen degradation", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-9637628:r:Modulation by Mtb of host immune system"], "type": "Homologous_superfamily"}, "IPR016188": {"description": "PurM-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PurM-like_N", "pathway_ids": ["R-SSC-2408557", "R-SPO-73817", "R-HSA-2408557", "R-DDI-73817", "R-MMU-2408557", "R-DME-73817", "R-DRE-2408557", "R-DME-2408557", "R-DDI-2408557", "R-CEL-2408557", "R-SCE-73817", "R-BTA-73817", "R-MMU-73817", "R-HSA-73817", "R-GGA-419140"], "pathways": ["R-SSC-2408557:r:Selenocysteine synthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-2408557:r:Selenocysteine synthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-2408557:r:Selenocysteine synthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DRE-2408557:r:Selenocysteine synthesis", "R-DME-2408557:r:Selenocysteine synthesis", "R-DDI-2408557:r:Selenocysteine synthesis", "R-CEL-2408557:r:Selenocysteine synthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Domain"}, "IPR016189": {"description": "Translation 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"R-HSA-9821002", "R-CEL-499943", "R-MMU-6798695", "R-BTA-73817", "R-HSA-73817", "R-SCE-73614", "R-HSA-9725370", "R-RNO-499943"], "pathways": ["R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-73614:r:Pyrimidine salvage", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73614:r:Pyrimidine salvage", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-72200:r:mRNA Editing: C to U Conversion", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-72200:r:mRNA Editing: C to U Conversion", 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biosynthesis", "R-SCE-73614:r:Pyrimidine salvage", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Homologous_superfamily"}, "IPR016194": {"description": "SPOC-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "SPOC-like_C_dom_sf", "pathway_ids": ["R-HSA-3270619", "R-HSA-6798695", "R-SPO-6798695", "R-HSA-5693571", "R-DDI-6798695", "R-MMU-9013422", "R-HSA-9013422", "R-GGA-353423", "R-DME-6798695", "R-DDI-5693571", "R-HSA-1834949", "R-SCE-6798695", "R-MMU-6798695", "R-DME-9013422", "R-MMU-5693571", "R-HSA-164843"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Homologous_superfamily"}, "IPR016195": {"description": "Polymerase/histidinol phosphatase-like", "go_ids": [], "go_terms": [], "name": "Pol/histidinol_Pase-like", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-HSA-6784531"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Homologous_superfamily"}, "IPR016197": {"description": "Chromo-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Chromo-like_dom_sf", "pathway_ids": ["R-HSA-4655427", "R-HSA-73772", "R-HSA-2559580", "R-MMU-4570464", "R-MMU-3214815", "R-HSA-427413", "R-MMU-6804756", "R-RNO-5693565", "R-HSA-5693565", "R-RNO-9018519", "R-MMU-5685938", "R-MMU-69473", "R-MMU-4551638", "R-HSA-427359", "R-HSA-9844594", "R-HSA-4570464", "R-DRE-3769402", "R-MMU-3214841", "R-DME-9772755", "R-HSA-69473", "R-HSA-983231", "R-HSA-9764725", "R-HSA-9609690", "R-MMU-9031628", "R-RNO-5693571", "R-RNO-9764725", "R-HSA-6804756", "R-RNO-5693568", "R-MMU-6804758", "R-DME-2559586", "R-MMU-3108214", "R-HSA-9031628", "R-CEL-9031628", "R-HSA-5685942", "R-HSA-9772755", "R-DME-5693565", "R-DME-427359", "R-RNO-5693548", "R-SCE-6804758", "R-DME-3214815", "R-MMU-5693565", "R-DME-4570464", "R-RNO-5685938", "R-HSA-9843970", "R-DME-8953750", "R-DME-9031628", "R-MMU-9772755", "R-MMU-5693579", "R-HSA-5693568", "R-DME-3108214", "R-MMU-5693607", "R-HSA-9701192", "R-MMU-3214847", "R-MMU-3899300", "R-HSA-381340", "R-HSA-9707616", "R-HSA-9709603", "R-MMU-8943724", "R-RNO-5685942", "R-HSA-201722", "R-HSA-5693571", "R-RNO-3214847", "R-DME-3214847", "R-HSA-9733709", "R-CEL-9018519", "R-HSA-427389", "R-HSA-3214847", "R-RNO-3769402", "R-HSA-5693579", "R-HSA-2426168", "R-MMU-9707564", "R-CEL-983231", "R-MMU-8953750", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-5693616", "R-MMU-5693616", "R-HSA-1368108", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-9772755", "R-HSA-9933387", "R-HSA-8943724", "R-CEL-4551638", "R-HSA-9707564", "R-DME-6804758", "R-MMU-5693568", "R-HSA-4551638", "R-HSA-9018519", "R-DME-5693607", "R-RNO-5693579", "R-MMU-2559586", "R-DME-9018519", "R-RNO-5693607", "R-HSA-3214815", "R-RNO-69473", "R-MMU-9018519", "R-HSA-8939243", "R-HSA-9704331", "R-DME-9843940", "R-HSA-400206", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-MMU-5693571", "R-HSA-2559586", "R-DME-8943724", "R-MMU-400206", "R-HSA-9818027", "R-DME-8939243", "R-MMU-73762", "R-HSA-3108214", "R-HSA-3769402", "R-HSA-9704646", "R-CEL-201722", "R-MMU-983231", "R-HSA-8953750", "R-DME-2559580", "R-HSA-6804758", "R-CEL-8943724", "R-HSA-3214841", "R-HSA-9845323", "R-DME-3899300", "R-DME-983231", "R-RNO-6804756", "R-HSA-5685938", "R-HSA-9931509", "R-MMU-3769402", "R-RNO-2559586", "R-MMU-5693548", "R-HSA-9679191", "R-HSA-73762", "R-MMU-5685942", "R-MMU-8939243", "R-DME-201722", "R-DRE-3214841", "R-SPO-6804758", "R-HSA-9843940", "R-DME-5693548", "R-HSA-3899300", "R-DME-73772", "R-RNO-9843970"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", 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"R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9031628:r:NGF-stimulated transcription", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-427359:r:SIRT1 negatively regulates rRNA expression", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-3214815:r:HDACs deacetylate histones", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-DME-9031628:r:NGF-stimulated transcription", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-3214847:r:HATs acetylate histones", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-HSA-9733709:r:Cardiogenesis", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3214815:r:HDACs deacetylate histones", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-DME-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "type": "Homologous_superfamily"}, "IPR016201": {"description": "PSI domain", "go_ids": [], "go_terms": [], "name": "PSI", "pathway_ids": ["R-HSA-9013405", "R-HSA-8874081", "R-MMU-210991", "R-HSA-6802952", "R-MMU-6811558", "R-HSA-3000178", "R-RNO-372708", "R-MMU-9013408", "R-MMU-210990", "R-HSA-9856532", "R-MMU-445355", "R-RNO-416550", "R-MMU-3000170", "R-HSA-6806942", "R-RNO-399954", "R-RNO-9634597", "R-MMU-8851805", "R-RNO-6811558", 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["GO:0004455:ketol-acid reductoisomerase activity:F"], "name": "KetolA_reductoisomerase_plant", "pathway_ids": ["PWY-7111", "PWY-5103"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-5103:t:L-isoleucine biosynthesis III"], "type": "Family"}, "IPR016207": {"description": "Ketol-acid reductoisomerase, fungi", "go_ids": ["GO:0004455"], "go_terms": ["GO:0004455:ketol-acid reductoisomerase activity:F"], "name": "KetolA_reductoisomerase_fun", "pathway_ids": ["PWY-7111", "PWY-5103"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-5103:t:L-isoleucine biosynthesis III"], "type": "Family"}, "IPR016208": {"description": "Aldehyde oxidase/xanthine dehydrogenase-like", "go_ids": ["GO:0005506", "GO:0016491"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "Ald_Oxase/xanthine_DH-like", "pathway_ids": ["R-MMU-9748787", "R-RNO-8851680", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", 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"R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Family"}, "IPR016209": {"description": "Protochlorophyllide reductase, ChlB, light independent", "go_ids": ["GO:0016730", "GO:0046148"], "go_terms": ["GO:0016730:oxidoreductase activity, acting on iron-sulfur proteins as donors:F", "GO:0046148:pigment biosynthetic process:P"], "name": "Protochlorophyllide_Rdtase", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Family"}, "IPR016210": {"description": "NAD-dependent glutamate dehydrogenase, eukaryotes", "go_ids": ["GO:0004352", "GO:0006538"], "go_terms": ["GO:0004352:L-glutamate dehydrogenase (NAD+) activity:F", "GO:0006538:L-glutamate catabolic process:P"], "name": "NAD-GDH_euk", "pathway_ids": ["PWY-6728", "PWY-5022", "PWY-7126", "PWY-8190"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-7126:t:ethene biosynthesis IV (engineered)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)"], "type": "Family"}, "IPR016211": {"description": "Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, bacterial/archaeal", "go_ids": ["GO:0016639"], "go_terms": ["GO:0016639:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor:F"], "name": "Glu/Phe/Leu/Val/Trp_DH_bac/arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016212": {"description": "Methyl coenzyme M reductase, alpha subunit", "go_ids": ["GO:0050524", "GO:0015948"], "go_terms": ["GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F", "GO:0015948:methanogenesis:P"], "name": "Me_CoM_Rdtase_asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016213": {"description": "Polyphenol oxidase", "go_ids": ["GO:0004097", "GO:0046148"], "go_terms": ["GO:0004097:catechol oxidase activity:F", "GO:0046148:pigment biosynthetic process:P"], "name": "Polyphenol_oxidase", "pathway_ids": ["PWY-6752"], "pathways": ["PWY-6752:t:ortho-quinones biosynthesis"], "type": "Family"}, "IPR016214": {"description": "NAD-reducing hydrogenase, HoxS gamma subunit", "go_ids": [], "go_terms": [], "name": "NAD-red_Hydgase_HoxS_gsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016215": {"description": "Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A", "go_ids": ["GO:0004497"], "go_terms": ["GO:0004497:monooxygenase activity:F"], "name": "NTA_MOA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016216": {"description": "Monophenol monooxygenase, fungi", "go_ids": ["GO:0004503"], "go_terms": ["GO:0004503:tyrosinase activity:F"], "name": "Monophenol_mOase_fun", "pathway_ids": ["PWY-7913", "PWY-7917", "PWY-6481"], "pathways": ["PWY-7913:t:firefly bioluminescence", "PWY-7917:t:pheomelanin biosynthesis", "PWY-6481:t:L-dopa and L-dopachrome biosynthesis"], "type": "Family"}, "IPR016217": {"description": "Nitrogen fixation, NifU", "go_ids": [], "go_terms": [], "name": "N_fixation_NifU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016218": {"description": "Acetyl-CoA decarbonylase/synthase complex, gamma subunit", "go_ids": ["GO:0005506", "GO:0008168", "GO:0046356"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0008168:methyltransferase activity:F", "GO:0046356:acetyl-CoA catabolic process:P"], "name": "AcylCoA_decarb/synth_gsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016219": {"description": "Phosphatidylethanolamine N-methyltransferase, fungi", "go_ids": ["GO:0004608", "GO:0006644"], "go_terms": ["GO:0004608:phosphatidylethanolamine N-methyltransferase activity:F", "GO:0006644:phospholipid metabolic process:P"], "name": "Phosphatid-EA_MeTrfase_fun", "pathway_ids": ["PWY-6825"], "pathways": ["PWY-6825:t:phosphatidylcholine biosynthesis V"], "type": "Family"}, "IPR016220": {"description": "Methylphosphotriester-DNA alkyltransferase, AdaA", "go_ids": [], "go_terms": [], "name": "Me-P-triester_DNA_alkyl-Trfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016221": {"description": "Bifunctional regulatory protein Ada", "go_ids": [], "go_terms": [], "name": "Bifunct_regulatory_prot_Ada", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016222": {"description": "Glycerol-3-phosphate O-acyltransferase, chloroplast", "go_ids": ["GO:0006650", "GO:0004366"], "go_terms": ["GO:0006650:glycerophospholipid metabolic process:P", "GO:0004366:glycerol-3-phosphate O-acyltransferase activity:F"], "name": "G3P_O-acylTrfase_chlp", "pathway_ids": ["PWY-5667", "PWY-8053", "PWY-7587", "PWY-8051", "PWY-8055", "PWY-6453", "PWY-7411"], "pathways": ["PWY-5667:t:CDP-diacylglycerol biosynthesis I", "PWY-8053:t:anandamide biosynthesis II", "PWY-7587:t:oleate biosynthesis III (cyanobacteria)", "PWY-8051:t:anandamide biosynthesis I", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-7411:t:phosphatidate biosynthesis (yeast)"], "type": "Family"}, "IPR016223": {"description": "DNA alpha-glucosyltransferase", "go_ids": [], "go_terms": [], "name": "DNA_alpha-glucosyltransferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016224": {"description": "Ecdysteroid UDP-glucosyltransferase", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "Ecdysteroid_UDP-Glc_Trfase", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin 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"PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene 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biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR016225": {"description": "NAD--protein ADP-ribosyltransferase Alt-like", "go_ids": ["GO:0106274"], "go_terms": ["GO:0106274:NAD+-protein-arginine ADP-ribosyltransferase activity:F"], "name": "Phage_T4_Alt-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016227": {"description": "Dihydropteroate synthase, predicted", "go_ids": [], "go_terms": [], "name": "Dihydropteroate_synthase_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016229": {"description": "Thiamine-phosphate synthase, cyanobacterial/bacterial", "go_ids": ["GO:0004789", "GO:0009228"], "go_terms": ["GO:0004789:thiamine-phosphate diphosphorylase activity:F", "GO:0009228:thiamine biosynthetic process:P"], "name": "TMP_synthase_cyanobac_bac", "pathway_ids": ["PWY-8457", "PWY-6894", "PWY-6908", "PWY-6907", "PWY-7356", "PWY-6897", "PWY-6893"], "pathways": ["PWY-8457:t:thiamine diphosphate salvage V", "PWY-6894:t:thiamine diphosphate biosynthesis I (E. coli)", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "PWY-6897:t:thiamine diphosphate salvage II", "PWY-6893:t:thiamine diphosphate biosynthesis II (Bacillus)"], "type": "Family"}, "IPR016230": {"description": "Serine-protein kinase PrkA/YeaG", "go_ids": ["GO:0004672"], "go_terms": ["GO:0004672:protein kinase activity:F"], "name": "PrkA/YeaG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016231": {"description": "Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4", "go_ids": ["GO:0004709"], "go_terms": ["GO:0004709:MAP kinase kinase kinase activity:F"], "name": "MLK1-4", "pathway_ids": ["R-RNO-5673000", "R-HSA-5673000", "R-RNO-9013424", "R-HSA-9649948", "R-HSA-6802946", "R-HSA-9013148", "R-MMU-5673000", "R-RNO-9013408", "R-MMU-9013424", "R-HSA-9013408", "R-MMU-9013408", "R-HSA-9013424", "R-HSA-6802955"], "pathways": ["R-RNO-5673000:r:RAF activation", "R-HSA-5673000:r:RAF activation", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-5673000:r:RAF activation", "R-RNO-9013408:r:RHOG GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF"], "type": "Family"}, "IPR016233": {"description": "Homeobox protein Pitx/unc30", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "Homeobox_Pitx/unc30", "pathway_ids": ["R-HSA-8866906"], "pathways": ["R-HSA-8866906:r:TFAP2 (AP-2) family regulates transcription of other transcription factors"], "type": "Family"}, "IPR016234": {"description": "Serine/threonine-protein kinase, Sbk1", "go_ids": ["GO:0004674", "GO:0005524", "GO:0006468"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P"], "name": "Ser/Thr_kinase_Sbk1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016235": {"description": "Tyrosine/threonine-protein kinase, Cdc2 inhibitor", "go_ids": ["GO:0004674", "GO:0006468", "GO:0016020"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0006468:protein phosphorylation:P", "GO:0016020:membrane:C"], "name": "Tyr/Thr_kinase_Cdc2_inhib", "pathway_ids": ["R-DME-69273", "R-MMU-156711", "R-HSA-69478", "R-HSA-156711", "R-HSA-69273", "R-DME-156711", "R-MMU-69273", "R-DME-69478", "R-MMU-69478"], "pathways": ["R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-156711:r:Polo-like kinase mediated events", "R-HSA-69478:r:G2/M DNA replication checkpoint", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-156711:r:Polo-like kinase mediated events", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-69478:r:G2/M DNA replication checkpoint", "R-MMU-69478:r:G2/M DNA replication checkpoint"], "type": "Family"}, "IPR016236": {"description": "Serine/threonine-protein kinase PknK, predicted", "go_ids": [], "go_terms": [], "name": "Ser/Thr_kinase_PknK_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016237": {"description": "Serine/threonine-protein kinase, 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"R-MMU-8854214:r:TBC/RABGAPs"], "type": "Family"}, "IPR016238": {"description": "Ribosomal protein S6 kinase", "go_ids": ["GO:0004674", "GO:0006468", "GO:0007165"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0006468:protein phosphorylation:P", "GO:0007165:signal transduction:P"], "name": "Ribosomal_S6_kinase", "pathway_ids": ["R-HSA-166208", "R-CEL-166208", "R-CEL-198693", "R-HSA-5674400", "R-RNO-166208", "R-HSA-198693", "R-MMU-166208"], "pathways": ["R-HSA-166208:r:mTORC1-mediated signalling", "R-CEL-166208:r:mTORC1-mediated signalling", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-MMU-166208:r:mTORC1-mediated signalling"], "type": "Family"}, "IPR016239": {"description": "Ribosomal protein S6 kinase II", "go_ids": ["GO:0000287", "GO:0004674", "GO:0006468", 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MITF-M expression and activity", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-RNO-444257:r:RSK activation", "R-CEL-444257:r:RSK activation", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CEL-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-RNO-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-MMU-199920:r:CREB phosphorylation", "R-MMU-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-DRE-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-DRE-444257:r:RSK activation", "R-CEL-198753:r:ERK/MAPK targets", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-199920:r:CREB phosphorylation", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-GGA-198753:r:ERK/MAPK targets", "R-CEL-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-198753:r:ERK/MAPK targets", "R-CEL-199920:r:CREB phosphorylation", "R-CEL-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-GGA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-437239:r:Recycling pathway of L1", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-199920:r:CREB phosphorylation", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-GGA-199920:r:CREB phosphorylation", "R-MMU-444257:r:RSK activation", "R-RNO-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-444257:r:RSK activation", "R-MMU-198753:r:ERK/MAPK targets", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-198753:r:ERK/MAPK targets", "R-MMU-375165:r:NCAM signaling for neurite out-growth"], "type": "Family"}, "IPR016240": {"description": "Serine/threonine-protein kinase YKL116C, predicted", "go_ids": [], "go_terms": [], "name": "Ser/Thr_kin_YKL116c_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016241": {"description": "Nitrogen network kinase 1", "go_ids": ["GO:0004672", "GO:0006468"], "go_terms": ["GO:0004672:protein kinase activity:F", "GO:0006468:protein phosphorylation:P"], "name": "Nnk1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016242": {"description": "Serine/threonine-protein kinase Mps1", "go_ids": ["GO:0004712", "GO:0006468", "GO:0004674", "GO:0007094", "GO:0030474"], "go_terms": ["GO:0004712:protein serine/threonine/tyrosine kinase activity:F", "GO:0006468:protein phosphorylation:P", "GO:0004674:protein serine/threonine kinase activity:F", "GO:0007094:mitotic spindle assembly checkpoint signaling:P", "GO:0030474:spindle pole body duplication:P"], "name": "Mps1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016244": {"description": "Tyrosine-protein kinase, HGF/MSP receptor", "go_ids": ["GO:0004714", "GO:0005524", "GO:0007169", "GO:0016020"], "go_terms": ["GO:0004714:transmembrane receptor protein tyrosine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0007169:cell surface receptor protein tyrosine kinase signaling pathway:P", "GO:0016020:membrane:C"], "name": "Tyr_kinase_HGF/MSP_rcpt", "pathway_ids": ["R-SSC-1257604", "R-SSC-8875513", "R-HSA-416550", "R-HSA-8874081", "R-HSA-8875555", "R-MMU-6811558", "R-RNO-1257604", "R-MMU-8875791", "R-RNO-416550", "R-RNO-9734091", "R-MMU-8865999", "R-SSC-6811558", "R-HSA-6806942", "R-HSA-8875360", "R-RNO-8874081", "R-RNO-8875513", "R-MMU-8874081", "R-MMU-8852405", "R-MMU-8851805", "R-HSA-8851907", "R-RNO-6811558", "R-SSC-8874081", "R-SSC-9734091", "R-HSA-8875513", "R-HSA-8851805", "R-HSA-9825892", "R-RNO-8865999", "R-RNO-5673001", "R-MMU-5673001", "R-MMU-9734091", "R-SSC-8851907", "R-HSA-9734091", "R-RNO-6806942", "R-HSA-8875791", "R-HSA-8852405", "R-SSC-6807004", "R-RNO-8875791", "R-SSC-8875555", "R-HSA-2219530", "R-HSA-6807004", "R-MMU-1257604", "R-SSC-416550", "R-HSA-5673001", "R-HSA-6811558", "R-MMU-8875555", "R-RNO-6807004", "R-SSC-5673001", "R-RNO-8875656", "R-RNO-8851907", "R-MMU-6806942", "R-RNO-8851805", "R-MMU-8851907", "R-MMU-8875656", "R-SSC-8875791", "R-HSA-9022699", "R-MMU-6807004", "R-MMU-8875513", "R-HSA-8875656", "R-RNO-8875555", "R-SSC-8865999", "R-HSA-1257604", "R-SSC-6806942", "R-SSC-8851805", "R-SSC-8875656", "R-HSA-8865999", "R-MMU-416550"], "pathways": ["R-SSC-1257604:r:PIP3 activates AKT signaling", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-HSA-416550:r:Sema4D 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cascade:FGFR1", "R-RNO-445144:r:Signal transduction by L1", "R-DME-109704:r:PI3K Cascade", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DRE-190371:r:FGFR3b ligand binding and activation"], "type": "Family"}, "IPR016249": {"description": "Tyrosine-protein kinase, Ret receptor", "go_ids": [], "go_terms": [], "name": "Tyr_kinase_Ret_rcpt", "pathway_ids": ["R-HSA-9830674", "R-HSA-8853659", "R-RNO-8853659", "R-HSA-9830364", "R-MMU-8853659", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-9768919", "R-HSA-5673001"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8853659:r:RET signaling", "R-RNO-8853659:r:RET signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-MMU-8853659:r:RET signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Family"}, "IPR016250": {"description": "Tyrosine-protein kinase, Fes/Fps type", "go_ids": ["GO:0004715", "GO:0018108"], "go_terms": ["GO:0004715:non-membrane spanning protein tyrosine kinase activity:F", "GO:0018108:peptidyl-tyrosine phosphorylation:P"], "name": "Tyr-prot_kinase_Fes/Fps", "pathway_ids": ["R-RNO-1433557", "R-HSA-399956", "R-MMU-1433557", "R-HSA-399954", "R-MMU-399954", 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"R-HSA-9674555", "R-DRE-6788467", "R-MMU-69231", "R-HSA-449836", "R-RNO-9674555", "R-MMU-112411", "R-RNO-1059683", "R-DRE-9705462", "R-HSA-1169408", "R-MMU-983231", "R-DRE-110056", "R-HSA-3214858", "R-MMU-9931295", "R-SSC-877312", "R-HSA-6802946", "R-RNO-110056", "R-HSA-912694", "R-MMU-6788467", "R-MMU-110056", "R-DRE-1059683", "R-MMU-8854691", "R-RNO-112411", "R-HSA-9020591", "R-MMU-1170546", "R-RNO-1266695", "R-SSC-9027276", "R-SSC-9020956", "R-MMU-8984722", "R-DRE-9020958", "R-RNO-982772", "R-HSA-9679191", "R-HSA-1433557", "R-MMU-1169408", "R-MMU-9006335", "R-MMU-877300", "R-RNO-8985947", "R-SSC-5673001", "R-MMU-1059683", "R-MMU-6783783", "R-HSA-9705462", "R-MMU-912694", "R-SSC-6788467"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", 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signaling", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-2586552:r:Signaling by Leptin", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5673000:r:RAF activation", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5673000:r:RAF activation", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DRE-8983432:r:Interleukin-15 signaling", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DRE-877312:r:Regulation of IFNG signaling", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-201556:r:Signaling by ALK", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-SSC-9020591:r:Interleukin-12 signaling", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DRE-1266695:r:Interleukin-7 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-9020558:r:Interleukin-2 signaling", "R-DRE-877300:r:Interferon gamma signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-201556:r:Signaling by ALK", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-877312:r:Regulation of IFNG signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-DRE-1059683:r:Interleukin-6 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-RNO-1266695:r:Interleukin-7 signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-DRE-9020958:r:Interleukin-21 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Family"}, "IPR016252": {"description": "Serine/threonine-protein kinase SpkB", "go_ids": [], "go_terms": [], "name": "Ser/Thr_kinase_SpkB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016254": {"description": "Serine/threonine-protein kinase, asfivirus", "go_ids": ["GO:0004674", "GO:0005524", "GO:0006468", "GO:0016032"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P", "GO:0016032:viral process:P"], "name": "Ser/Thr_kinase_asfivir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016255": {"description": "eIF-2-alpha kinase Gcn2", "go_ids": ["GO:0006468", "GO:0004694", "GO:0000077", "GO:0010998"], "go_terms": ["GO:0006468:protein phosphorylation:P", "GO:0004694:eukaryotic translation initiation factor 2alpha kinase activity:F", "GO:0000077:DNA damage checkpoint signaling:P", "GO:0010998:regulation of translational initiation by eIF2 alpha phosphorylation:P"], "name": "Gcn2", "pathway_ids": ["R-HSA-9633012"], "pathways": ["R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR016256": {"description": "Serine/threonine-protein kinase Rad53", "go_ids": ["GO:0000077", "GO:0005634", "GO:0006281", "GO:0004712", "GO:0003688", "GO:0009202", "GO:0006270"], "go_terms": ["GO:0000077:DNA damage checkpoint signaling:P", "GO:0005634:nucleus:C", "GO:0006281:DNA repair:P", "GO:0004712:protein serine/threonine/tyrosine kinase activity:F", "GO:0003688:DNA replication origin binding:F", "GO:0009202:deoxyribonucleoside triphosphate biosynthetic process:P", "GO:0006270:DNA replication initiation:P"], "name": "Ser/Thr_kinase_Rad53", "pathway_ids": ["R-SCE-75035", "R-SCE-69601", "R-SCE-5693565", "R-SCE-69473"], "pathways": ["R-SCE-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-SCE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-69473:r:G2/M DNA damage checkpoint"], "type": "Family"}, "IPR016257": {"description": "Ephrin receptor type-A /type-B", "go_ids": ["GO:0005003", "GO:0005524", "GO:0005886", "GO:0006468", "GO:0007169"], "go_terms": ["GO:0005003:ephrin receptor activity:F", "GO:0005524:ATP binding:F", "GO:0005886:plasma membrane:C", "GO:0006468:protein phosphorylation:P", "GO:0007169:cell surface receptor protein tyrosine kinase signaling pathway:P"], "name": "EPH", "pathway_ids": ["R-MMU-3928665", "R-DRE-3928662", "R-MMU-9013408", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-9824272", "R-HSA-373760", "R-HSA-3928662", "R-DRE-3928664", "R-HSA-9013423", "R-MMU-9013420", "R-RNO-3928665", "R-RNO-3928662", "R-HSA-2682334", "R-HSA-9696273", "R-HSA-9013408", "R-MMU-3928664", "R-DRE-2682334", "R-HSA-9013420", "R-HSA-3928664", "R-HSA-9696270", "R-RNO-2682334", "R-MMU-9013424", "R-MMU-2682334", "R-RNO-3928663", "R-MMU-3928663", "R-RNO-3928664", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-3928663", "R-HSA-3928665", "R-MMU-3928662", "R-DRE-3928665", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-2892247", "R-MMU-9696273", "R-MMU-9013149", "R-DRE-3928663"], "pathways": ["R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9824272:r:Somitogenesis", "R-HSA-373760:r:L1CAM interactions", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DRE-3928664:r:Ephrin signaling", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse"], "type": "Family"}, "IPR016258": {"description": "Multiphosphoryl transfer protein FruB", "go_ids": [], "go_terms": [], "name": "FruB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016259": {"description": "Hygromycin-B kinase", "go_ids": [], "go_terms": [], "name": "Hygromycin-B_Kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016261": {"description": "Folic acid synthesis protein FOL1", "go_ids": ["GO:0003848", "GO:0004150", "GO:0004156", "GO:0046654"], "go_terms": ["GO:0003848:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity:F", "GO:0004150:dihydroneopterin aldolase activity:F", "GO:0004156:dihydropteroate synthase activity:F", "GO:0046654:tetrahydrofolate biosynthetic process:P"], "name": "Folic_acid_synth", "pathway_ids": ["PWY-7853", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7852", "PWY-6614", "PWY-6148"], "pathways": ["PWY-7853:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis V (Pyrococcus)", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7852:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)", "PWY-6614:t:tetrahydrofolate biosynthesis I", "PWY-6148:t:tetrahydromethanopterin biosynthesis"], "type": "Family"}, "IPR016262": {"description": "RNA polymerase sigma factor, SigB/C/D/F, plastid", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma_SigB/C/D/F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016266": {"description": "DNA polymerase epsilon, subunit B", "go_ids": ["GO:0006261", "GO:0003677", "GO:0008622"], "go_terms": ["GO:0006261:DNA-templated DNA replication:P", "GO:0003677:DNA binding:F", "GO:0008622:epsilon DNA polymerase complex:C"], "name": "POLE2", "pathway_ids": ["R-DDI-6782135", "R-DME-110314", "R-HSA-5685942", "R-MMU-6782135", "R-CEL-68962", "R-SPO-5656169", "R-HSA-5696397", "R-DDI-6782210", "R-MMU-110314", "R-DDI-68952", "R-CEL-110314", "R-DME-68962", "R-DDI-68962", "R-GGA-353303", "R-HSA-68962", "R-HSA-6782210", "R-CEL-5656169", "R-DME-68952", "R-HSA-5656169", "R-DME-6782135", "R-SCE-68952", "R-MMU-5696400", "R-SPO-5696397", "R-DME-5651801", "R-HSA-68952", "R-MMU-68962", "R-MMU-5651801", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-CEL-6782210", "R-HSA-5651801", "R-CEL-5696397", "R-SCE-68962", "R-MMU-68952", "R-DME-5656169", "R-SPO-5696400", "R-SPO-68952", "R-CEL-68952", "R-SPO-110314", "R-SPO-6782210", "R-CEL-6782135", "R-DME-5696400", "R-SPO-68962", "R-HSA-5696400", "R-MMU-6782210", "R-HSA-110314", "R-SPO-6782135", "R-MMU-5696397", "R-CEL-5651801", "R-SCE-6782135", "R-SPO-5651801"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-68952:r:DNA replication initiation", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5656169:r:Termination of translesion DNA synthesis", "R-DME-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-68952:r:DNA replication initiation", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-68952:r:DNA replication initiation", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-MMU-68952:r:DNA replication initiation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-68952:r:DNA replication initiation", "R-CEL-68952:r:DNA replication initiation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR016267": {"description": "UTP--glucose-1-phosphate uridylyltransferase", "go_ids": ["GO:0006011", "GO:0003983"], "go_terms": ["GO:0006011:UDP-alpha-D-glucose metabolic process:P", "GO:0003983:UTP:glucose-1-phosphate uridylyltransferase activity:F"], "name": "UDPGP_trans", "pathway_ids": ["PWY-6527", "PWY-7817", "PWY-7343", "PWY-7238", "PWY-3801", "R-BTA-173599", "R-DDI-3322077", "R-SPO-173599", "R-SPO-3322077", "R-SCE-173599", "R-MMU-3322077", "R-HSA-3322077", "R-DDI-173599", "R-SCE-3322077", "R-BTA-3322077", "R-HSA-173599", "R-MMU-173599"], "pathways": ["PWY-6527:t:stachyose degradation", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7343:t:UDP-alpha-D-glucose biosynthesis", "PWY-7238:t:sucrose biosynthesis II", "PWY-3801:t:sucrose degradation II (sucrose synthase)", "R-BTA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DDI-3322077:r:Glycogen synthesis", "R-SPO-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-SPO-3322077:r:Glycogen synthesis", "R-SCE-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-3322077:r:Glycogen synthesis", "R-HSA-3322077:r:Glycogen synthesis", "R-DDI-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-SCE-3322077:r:Glycogen synthesis", "R-BTA-3322077:r:Glycogen synthesis", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate"], "type": "Family"}, "IPR016268": {"description": "RNA-directed RNA polymerase, hantavirus", "go_ids": ["GO:0003968", "GO:0019079"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0019079:viral genome replication:P"], "name": "RNA-dir_pol_hantavirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016269": {"description": "RNA-directed RNA polymerase, paramyxovirus", "go_ids": ["GO:0006139", "GO:0016740"], "go_terms": ["GO:0006139:nucleobase-containing compound metabolic process:P", "GO:0016740:transferase activity:F"], "name": "RNA-dir_pol_paramyxovirus", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR016270": {"description": "CDP-alcohol phosphatidyltransferase class-II family", "go_ids": ["GO:0008444", "GO:0032049"], "go_terms": ["GO:0008444:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity:F", "GO:0032049:cardiolipin biosynthetic process:P"], "name": "PGS1", "pathway_ids": ["PWY-5668", "PWY-7817", "PWY-5269", "R-HSA-1483148"], "pathways": ["PWY-5668:t:cardiolipin biosynthesis I", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-5269:t:cardiolipin biosynthesis II", "R-HSA-1483148:r:Synthesis of PG"], "type": "Family"}, "IPR016271": {"description": "CDP-diacylglycerol--serine O-phosphatidyltransferase, fungal", "go_ids": [], "go_terms": [], "name": "CDP-diaglyc--ser_O-PTrfase_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016272": {"description": "Lipase, LIPH-type", "go_ids": 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"R-BTA-8852276", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-DME-5610785", "R-HSA-5689603", "R-RNO-983168", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DME-1169091", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-BTA-8941858", "R-DME-5610780", "R-DME-4641258", "R-HSA-174184", "R-SPO-1236974", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-MMU-9912633", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-RNO-4608870", "R-HSA-382556", "R-HSA-8852276", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-DME-5632684", "R-HSA-5687128", "R-DME-432395", "R-RNO-5658442", "R-MMU-1236974", "R-RNO-5610785", "R-MMU-983168", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-432524:r:Degradation of PER", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-SPO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9907900:r:Proteasome assembly", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-1236974:r:ER-Phagosome pathway", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-1236974:r:ER-Phagosome pathway", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-1236974:r:ER-Phagosome pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-5689603:r:UCH proteinases", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-1236974:r:ER-Phagosome pathway", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-SCE-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-RNO-1236974:r:ER-Phagosome pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DME-5689603:r:UCH proteinases", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-9907900:r:Proteasome assembly", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5689603:r:UCH proteinases", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-8951664:r:Neddylation", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-4641257:r:Degradation of AXIN", "R-DME-9907900:r:Proteasome assembly", "R-DDI-5689603:r:UCH proteinases", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-5632684:r:Hedgehog 'on' state", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of 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"R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-1296041:r:Activation of G protein gated Potassium channels", "R-CFA-500657:r:Presynaptic function of Kainate receptors", "R-CEL-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CFA-9634597:r:GPER1 signaling", "R-HSA-416476:r:G alpha (q) signalling events", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-CFA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DDI-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-CFA-420092:r:Glucagon-type ligand receptors", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-DME-418597:r:G alpha (z) signalling events", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-CEL-418594:r:G alpha (i) signalling events", "R-DRE-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-418594:r:G alpha (i) signalling events", "R-CFA-8964315:r:G beta:gamma signalling through BTK", "R-DRE-416476:r:G alpha (q) signalling events", "R-CFA-1296041:r:Activation of G protein gated Potassium channels", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Family"}, "IPR016347": {"description": "Acyl-CoA-binding domain-containing protein 5", "go_ids": ["GO:0000062", "GO:0000425"], "go_terms": ["GO:0000062:fatty-acyl-CoA binding:F", "GO:0000425:pexophagy:P"], "name": "ACBD5", "pathway_ids": ["R-XTR-9013106", "R-DRE-9013106", "R-MMU-9013106", "R-RNO-390918", "R-MMU-8980692", "R-RNO-9603798", "R-RNO-8980692", "R-XTR-390918", "R-HSA-9013106", "R-DRE-9603798", "R-HSA-390918", "R-MMU-390918", "R-XTR-8980692", "R-XTR-9603798", "R-HSA-8980692", "R-DRE-390918", "R-DRE-8980692", "R-RNO-9013106", "R-MMU-9603798", "R-HSA-9603798"], "pathways": ["R-XTR-9013106:r:RHOC GTPase cycle", "R-DRE-9013106:r:RHOC GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-390918:r:Peroxisomal lipid metabolism", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-8980692:r:RHOA GTPase cycle", "R-XTR-390918:r:Peroxisomal lipid metabolism", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DRE-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-MMU-390918:r:Peroxisomal lipid metabolism", "R-XTR-8980692:r:RHOA GTPase cycle", "R-XTR-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DRE-390918:r:Peroxisomal lipid metabolism", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import"], "type": "Family"}, "IPR016348": {"description": "L-selectin", "go_ids": ["GO:0007155", "GO:0050900"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0050900:leukocyte migration:P"], "name": "L-selectin", "pathway_ids": ["R-HSA-6798695", "R-MMU-198933", "R-RNO-198933", "R-RNO-202733", "R-MMU-202733", "R-HSA-198933", "R-MMU-6798695", "R-HSA-202733", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR016351": {"description": "Plasminogen-related", "go_ids": [], "go_terms": [], "name": "Plasminogen-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016352": {"description": "Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan", "go_ids": [], "go_terms": [], "name": "SLRP_I_decor/aspor/byglycan", "pathway_ids": ["R-RNO-2022923", "R-MMU-2022870", "R-CFA-2022870", "R-HSA-3000178", "R-HSA-3560783", "R-RNO-1474228", "R-HSA-3595172", "R-BTA-3000178", "R-MMU-3000178", "R-RNO-2024101", "R-BTA-2022870", "R-CFA-2024101", "R-HSA-3595177", "R-CFA-1971475", "R-RNO-3000178", "R-MMU-2022923", "R-RNO-2022870", "R-BTA-2024101", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-2024101", "R-BTA-1971475", "R-HSA-2022870", "R-BTA-1474228", "R-HSA-1971475", "R-HSA-3560801", "R-RNO-1971475", "R-HSA-2022923", "R-CFA-1474228", "R-HSA-4420332", "R-MMU-2024101", "R-BTA-2022923", "R-CFA-2022923", "R-MMU-1971475", "R-HSA-3595174"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-CFA-2022870:r:CS-GAG biosynthesis", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-BTA-3000178:r:ECM proteoglycans", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-2024101:r:CS/DS degradation", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-CFA-2024101:r:CS/DS degradation", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-CFA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-BTA-2024101:r:CS/DS degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2024101:r:CS/DS degradation", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-MMU-2024101:r:CS/DS degradation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-CFA-2022923:r:DS-GAG biosynthesis", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type"], "type": "Family"}, "IPR016353": {"description": "Chordin", "go_ids": ["GO:0007275"], "go_terms": ["GO:0007275:multicellular organism development:P"], "name": "Chordin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016355": {"description": "Nuclear hormone receptor family 5-like", "go_ids": ["GO:0003677", "GO:0004879"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004879:nuclear receptor activity:F"], "name": "NR5-like", "pathway_ids": ["R-DME-383280", "R-SSC-4090294", "R-HSA-452723", "R-HSA-9690406", "R-CEL-383280", "R-RNO-9018519", "R-HSA-9841922", "R-BTA-4090294", "R-HSA-383280", "R-MMU-383280", "R-BTA-383280", "R-CEL-4090294", "R-DRE-4090294", "R-SSC-383280", "R-HSA-210747", "R-HSA-4090294", "R-MMU-4090294", "R-DRE-383280", "R-DME-4090294", "R-RNO-4090294", "R-RNO-383280", "R-HSA-9018519"], "pathways": ["R-DME-383280:r:Nuclear Receptor transcription pathway", "R-SSC-4090294:r:SUMOylation of intracellular receptors", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", 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"IPR016416": {"description": "Bacteriophage T4, Gp31, chaperonin-GroEL", "go_ids": ["GO:0019069"], "go_terms": ["GO:0019069:viral capsid assembly:P"], "name": "Phage_T4_Gp31_GroEL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016417": {"description": "Spanin, inner membrane subunit, T7likevirus-type", "go_ids": [], "go_terms": [], "name": "I-spanin_T7likevirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016418": {"description": "Uncharacterized protein Rem", "go_ids": [], "go_terms": [], "name": "Rem", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016419": {"description": "Prepilin peptidase-dependent protein B, predicted", "go_ids": [], "go_terms": [], "name": "Prepilin_Pept-dep_B_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016420": {"description": "Uncharacterised conserved protein UCP004546", "go_ids": [], "go_terms": [], "name": "UCP004546", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016421": {"description": "Transposition, TnsE", "go_ids": [], "go_terms": [], "name": "Transposition_TnsE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016422": {"description": "Replication-associated protein RepA4", "go_ids": [], "go_terms": [], "name": "Rep_assoc_RepA4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016423": {"description": "Resolvase, Rsv", "go_ids": [], "go_terms": [], "name": "Resolvase_Rsv", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016424": {"description": "Cytochrome B pre-mRNA-processing protein 2", "go_ids": ["GO:0000372", "GO:0005739", "GO:0003723"], "go_terms": ["GO:0000372:Group I intron splicing:P", "GO:0005739:mitochondrion:C", "GO:0003723:RNA binding:F"], "name": "Cbp2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016425": {"description": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial", "go_ids": ["GO:0005506", "GO:0008299", "GO:0046429"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0008299:isoprenoid biosynthetic process:P", "GO:0046429:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin):F"], "name": "IspG_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016426": {"description": "L-aspartate semialdehyde sulfurtransferase MA1821-like", "go_ids": [], "go_terms": [], "name": "MA1821-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016427": {"description": "Uncharacterised conserved protein UCP004699, CBS/ParB-like", "go_ids": [], "go_terms": [], "name": "UCP004699_CBS/ParB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016428": {"description": "NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 2", "go_ids": ["GO:0005737", "GO:0008616", "GO:0046857"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008616:tRNA queuosine(34) biosynthetic process:P", "GO:0046857:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor:F"], "name": "QueF_type2", "pathway_ids": ["PWY-6700"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)"], "type": "Family"}, "IPR016429": {"description": "NAD biosynthesis/regulator protein NadR", "go_ids": ["GO:0050262", "GO:0009435", "GO:0000309"], "go_terms": ["GO:0050262:ribosylnicotinamide kinase activity:F", "GO:0009435:NAD+ biosynthetic process:P", "GO:0000309:nicotinamide-nucleotide adenylyltransferase activity:F"], "name": "NAD_NadR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016430": {"description": "Cytadherence high molecular weight protein 2", "go_ids": [], "go_terms": [], "name": "Cytadherence_Hmw2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016431": {"description": "Pyruvate-formate lyase-activating enzyme, predicted", "go_ids": [], "go_terms": [], "name": "Pyrv-formate_lyase-activ_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016432": {"description": "Ribonuclease P subunit RNP4", "go_ids": ["GO:0001682", "GO:0030677"], "go_terms": ["GO:0001682:tRNA 5'-leader removal:P", "GO:0030677:ribonuclease P complex:C"], "name": "RNP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016433": {"description": "Small GTPase superfamily, Uncharacterized protein MJ1339", "go_ids": [], "go_terms": [], "name": "Small_GTPase_MJ1339", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016435": {"description": "Diphthamide synthesis DPH1/DPH2", "go_ids": ["GO:0090560", "GO:0017183"], "go_terms": ["GO:0090560:2-(3-amino-3-carboxypropyl)histidine synthase activity:F", "GO:0017183:protein histidyl modification to diphthamide:P"], "name": "DPH1/DPH2", "pathway_ids": ["R-SPO-5358493", "R-CEL-5358493", "R-SCE-5358493", "R-MMU-5358493", "R-DDI-5358493", "R-HSA-5358493", "R-DRE-5358493"], "pathways": ["R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Family"}, "IPR016436": {"description": "Uncharacterised conserved protein UCP005063, CBS-type", "go_ids": [], "go_terms": [], "name": "UCP005063_CBS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016437": {"description": "MCT-1/Tma20", "go_ids": [], "go_terms": [], "name": "MCT-1/Tma20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016438": {"description": "Circadian oscillator component FRH-like", "go_ids": ["GO:0003723", "GO:0003724", "GO:0006401"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003724:RNA helicase activity:F", "GO:0006401:RNA catabolic process:P"], "name": "FRH-like", "pathway_ids": ["R-MMU-9930044", "R-MMU-6791226", "R-HSA-9930044", "R-HSA-390471", "R-MMU-72163", "R-MMU-429958", "R-SPO-9930044", "R-HSA-72163", "R-SCE-429958", "R-SCE-6791226", "R-HSA-6791226", "R-HSA-9843970", "R-CEL-9930044", "R-CEL-6791226", "R-HSA-429958", "R-CEL-72163", "R-SPO-429958", "R-SPO-72163", "R-SPO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR016439": {"description": "Sphingosine N-acyltransferase Lag1/Lac1-like", "go_ids": ["GO:0046513", "GO:0050291"], "go_terms": ["GO:0046513:ceramide biosynthetic process:P", "GO:0050291:sphingosine N-acyltransferase activity:F"], "name": "Lag1/Lac1-like", "pathway_ids": ["R-SCE-1660661", "R-SPO-1660661", "R-CEL-1660661", "R-HSA-1660661", "R-BTA-1660661", "R-MMU-1660661"], "pathways": ["R-SCE-1660661:r:Sphingolipid de novo biosynthesis", "R-SPO-1660661:r:Sphingolipid de novo biosynthesis", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR016440": {"description": "Rubredoxin-oxygen oxidoreductase", "go_ids": ["GO:0009055", "GO:0010181", "GO:0016491", "GO:0046872"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0010181:FMN binding:F", "GO:0016491:oxidoreductase activity:F", "GO:0046872:metal ion binding:F"], "name": "Rubredoxin-O_OxRdtase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016441": {"description": "TEL2-interacting protein 1", "go_ids": [], "go_terms": [], "name": "Tti1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016442": {"description": "tRNA-splicing endonuclease, archaeal short subfamily", "go_ids": [], "go_terms": [], "name": "tRNA_splic_arch_short", "pathway_ids": ["PWY-7803", "PWY-6689"], "pathways": ["PWY-7803:t:tRNA splicing II", "PWY-6689:t:tRNA splicing I"], "type": "Family"}, "IPR016443": {"description": "RNA 3'-terminal phosphate cyclase type 2", "go_ids": ["GO:0042254", "GO:0005730"], "go_terms": ["GO:0042254:ribosome biogenesis:P", "GO:0005730:nucleolus:C"], "name": "RNA3'_term_phos_cyc_type_2", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR016444": {"description": "Synaptobrevin/Vesicle-associated membrane protein", "go_ids": [], "go_terms": [], "name": "Synaptobrevin/VAMP", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-MMU-8856828", "R-HSA-9013409", "R-CEL-199992", "R-CEL-181430", "R-HSA-264876", "R-MMU-9013408", "R-MMU-181430", "R-CEL-888590", "R-BTA-9609523", "R-DDI-210500", "R-CEL-9013407", "R-DDI-8856825", "R-HSA-9662360", "R-MMU-199992", "R-HSA-210500", "R-MMU-449836", "R-DDI-6798695", "R-DME-9013149", "R-MMU-9035034", "R-RNO-6811440", "R-MMU-9013407", "R-BTA-181430", "R-HSA-181430", "R-HSA-5250955", "R-HSA-432720", "R-RNO-9013407", "R-CEL-212676", "R-RNO-199992", "R-MMU-9013423", "R-HSA-1445148", "R-HSA-9013026", "R-HSA-1236974", "R-CEL-8856825", "R-HSA-212676", "R-RNO-6798695", "R-DME-432720", "R-RNO-9035034", "R-MMU-8980692", "R-CEL-432720", "R-RNO-8980692", "R-CEL-210500", "R-HSA-9013106", "R-HSA-5250982", "R-HSA-199992", "R-HSA-9013423", "R-DME-449836", "R-HSA-181429", "R-HSA-9013148", "R-CEL-9013406", "R-RNO-8856828", "R-DME-199992", "R-BTA-449836", "R-BTA-264642", "R-CEL-9013423", "R-BTA-8856828", "R-CEL-8856828", "R-DME-6811440", "R-MMU-212676", "R-DME-6798695", "R-BTA-432720", "R-RNO-181430", "R-RNO-210500", "R-MMU-210500", "R-DME-432722", "R-RNO-9013423", "R-HSA-8856825", "R-DDI-9609523", "R-BTA-181429", "R-DDI-9013404", "R-MMU-9013149", "R-HSA-422356", "R-HSA-6798695", "R-CEL-8980692", "R-MMU-9013106", "R-HSA-8856828", "R-CEL-6798695", "R-BTA-199992", "R-CEL-432722", "R-RNO-9013149", "R-BTA-6798695", "R-MMU-9013404", "R-CEL-9035034", "R-CEL-6811440", "R-DME-9035034", "R-RNO-212676", "R-RNO-9013408", "R-RNO-9013406", "R-RNO-9013404", "R-HSA-9609523", "R-HSA-9013408", "R-DDI-9013423", "R-CEL-264642", "R-SCE-199992", "R-RNO-432722", "R-DME-210500", "R-DME-8980692", "R-RNO-432720", "R-HSA-5250989", "R-HSA-264642", "R-BTA-888590", "R-MMU-6811440", "R-MMU-264642", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-DME-181430", "R-MMU-9013406", "R-RNO-264642", "R-HSA-5250958", "R-MMU-6798695", "R-RNO-181429", "R-BTA-1236974", "R-HSA-9013407", "R-HSA-449836", "R-BTA-210500", "R-MMU-8856825", "R-DDI-199992", "R-MMU-432722", "R-RNO-1236974", "R-HSA-6811440", "R-RNO-9609523", "R-DME-264642", "R-HSA-5250981", "R-CEL-9013149", "R-DDI-9013149", "R-DME-888590", "R-CEL-9609523", "R-BTA-212676", "R-HSA-9035034", "R-DME-9013406", "R-DME-9609523", "R-DME-8856828", "R-DDI-6811440", "R-RNO-9013106", "R-CEL-181429", "R-MMU-432720", "R-DME-181429", "R-HSA-432722", "R-MMU-9609523", "R-DME-9013407", "R-DME-8856825", "R-DDI-449836", "R-RNO-8856825", "R-MMU-888590", "R-CEL-449836", "R-MMU-181429", "R-DME-212676", "R-HSA-888590", "R-BTA-8856825", "R-MMU-9013026", "R-MMU-1236974", "R-BTA-432722", "R-HSA-9013406", "R-RNO-888590", "R-RNO-449836", "R-DME-9013423"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-CEL-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-264876:r:Insulin processing", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-449836:r:Other interleukin signaling", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-9013407:r:RHOH GTPase cycle", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-5250955:r:Toxicity of botulinum toxin type D (botD)", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-9013407:r:RHOH GTPase cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-199992:r:trans-Golgi Network Vesicle Budding", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-1236974:r:ER-Phagosome pathway", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-5250982:r:Toxicity of tetanus toxin (tetX)", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-449836:r:Other interleukin signaling", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-199992:r:trans-Golgi Network Vesicle Budding", "R-BTA-449836:r:Other interleukin signaling", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-CEL-9035034:r:RHOF GTPase cycle", "R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SCE-199992:r:trans-Golgi Network Vesicle Budding", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5250989:r:Toxicity of botulinum toxin type G (botG)", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-5250958:r:Toxicity of botulinum toxin type B (botB)", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-1236974:r:ER-Phagosome pathway", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-449836:r:Other interleukin signaling", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-199992:r:trans-Golgi Network Vesicle Budding", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-1236974:r:ER-Phagosome pathway", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-5250981:r:Toxicity of botulinum toxin type F (botF)", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-9013106:r:RHOC GTPase cycle", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-9013407:r:RHOH GTPase cycle", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-449836:r:Other interleukin signaling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-CEL-449836:r:Other interleukin signaling", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-1236974:r:ER-Phagosome pathway", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-449836:r:Other interleukin signaling", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR016445": {"description": "Lipase Rog1", "go_ids": [], "go_terms": [], "name": "Rog1_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016446": {"description": "Flavin oxidoreductase Frp family", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Flavin_OxRdtase_Frp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016447": {"description": "Translocation associated membrane protein", "go_ids": ["GO:0006616"], "go_terms": ["GO:0006616:SRP-dependent cotranslational protein targeting to membrane, translocation:P"], "name": "Translocation_assoc_membrane", "pathway_ids": ["R-HSA-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR016449": {"description": "Potassium channel, inwardly rectifying, Kir", "go_ids": ["GO:0006813", "GO:0005242", "GO:0016020"], "go_terms": ["GO:0006813:potassium ion transport:P", "GO:0005242:inward rectifier potassium channel activity:F", "GO:0016020:membrane:C"], "name": "K_chnl_inward-rec_Kir", "pathway_ids": ["R-HSA-1296053", "R-SSC-1296053", "R-RNO-1296053", "R-MMU-422356", "R-MMU-1296025", "R-RNO-382556", "R-HSA-5576886", "R-GGA-5576886", "R-MMU-1296067", "R-CEL-1296067", "R-MMU-1296053", "R-CFA-997272", "R-BTA-1296041", "R-RNO-1296025", "R-HSA-9729555", "R-GGA-997272", "R-CFA-1296053", "R-HSA-1296041", "R-HSA-5578775", "R-CEL-5576886", "R-BTA-997272", "R-HSA-1296025", "R-SSC-997272", "R-HSA-997272", "R-HSA-1296067", "R-MMU-382556", "R-SSC-5576886", "R-RNO-997272", "R-RNO-5578775", "R-HSA-382556", "R-MMU-5578775", "R-MMU-5576886", "R-CFA-5576886", "R-MMU-1296041", "R-RNO-5576886", "R-RNO-1296041", "R-HSA-5678420", "R-BTA-1296053", "R-RNO-422356", "R-CEL-1296053", "R-GGA-1296053", "R-RNO-1296067", "R-MMU-997272", "R-BTA-5576886", "R-SSC-1296041", "R-GGA-1296041", "R-CFA-1296041", "R-CEL-997272", "R-CEL-1296041", "R-HSA-5683177", "R-HSA-422356"], "pathways": ["R-HSA-1296053:r:Classical Kir channels", "R-SSC-1296053:r:Classical Kir channels", "R-RNO-1296053:r:Classical Kir channels", "R-MMU-422356:r:Regulation of insulin secretion", "R-MMU-1296025:r:ATP sensitive Potassium channels", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5576886:r:Phase 4 - resting membrane potential", "R-GGA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296067:r:Potassium transport channels", "R-CEL-1296067:r:Potassium transport channels", "R-MMU-1296053:r:Classical Kir channels", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-1296025:r:ATP sensitive Potassium channels", "R-HSA-9729555:r:Sensory perception of sour taste", "R-GGA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CFA-1296053:r:Classical Kir channels", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5578775:r:Ion homeostasis", "R-CEL-5576886:r:Phase 4 - resting membrane potential", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296025:r:ATP sensitive Potassium channels", "R-SSC-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296067:r:Potassium transport channels", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-SSC-5576886:r:Phase 4 - resting membrane potential", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-5576886:r:Phase 4 - resting membrane potential", "R-CFA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-5576886:r:Phase 4 - resting membrane potential", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5678420:r:Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome", "R-BTA-1296053:r:Classical Kir channels", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-1296053:r:Classical Kir channels", "R-GGA-1296053:r:Classical Kir channels", "R-RNO-1296067:r:Potassium transport channels", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-5576886:r:Phase 4 - resting membrane potential", "R-SSC-1296041:r:Activation of G protein gated Potassium channels", "R-GGA-1296041:r:Activation of G protein gated Potassium channels", "R-CFA-1296041:r:Activation of G protein gated Potassium channels", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5683177:r:Defective ABCC8 can cause hypo- and hyper-glycemias", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Family"}, "IPR016450": {"description": "Uncharacterised conserved protein UCP005522", "go_ids": [], "go_terms": [], "name": "UCP005522", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016451": {"description": "Intermediate filament, ifa/ifb", "go_ids": [], "go_terms": [], "name": "Intermed_filament_ifa/ifb", "pathway_ids": ["R-CEL-9035034", "R-CEL-4419969", "R-CEL-2559584"], "pathways": ["R-CEL-9035034:r:RHOF GTPase cycle", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Family"}, "IPR016452": {"description": "Fatty acid synthase beta subunit AflB /Fas1-like, fungi", "go_ids": ["GO:0019171", "GO:0004313", "GO:0004318", "GO:0005835", "GO:0006633", "GO:0004314"], "go_terms": ["GO:0019171:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase 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biosynthesis initiation (plant mitochondria)", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWY-5367:t:petroselinate biosynthesis", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-7723:t:bacterial bioluminescence", "PWY-8012:t:mupirocin biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "PWY-6113:t:superpathway of mycolate biosynthesis", "PWY-5366:t:palmitoleate biosynthesis II (plants and bacteria)", "PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8049:t:pederin biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8279:t:palmitate biosynthesis III", "PWY-8047:t:bryostatin biosynthesis", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"], "type": "Family"}, "IPR016453": {"description": "Coatomer beta' subunit (COPB2)", "go_ids": [], "go_terms": [], "name": "COPB2", "pathway_ids": ["R-SPO-6807878", "R-DME-6811434", "R-BTA-6807878", "R-HSA-6811434", "R-CEL-6811434", "R-RNO-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-DDI-6807878", "R-RNO-6807878", "R-SPO-6811434", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-DME-6807878", "R-DDI-6811434", "R-BTA-6811434", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent 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"R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-DDI-9865881:r:Complex III assembly", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-9865881:r:Complex III assembly", "R-DME-1362409:r:Mitochondrial iron-sulfur cluster biogenesis"], "type": "Family"}, "IPR016455": {"description": "Xyloglucan endotransglucosylase/hydrolase", "go_ids": ["GO:0016762", "GO:0010411", "GO:0042546"], "go_terms": ["GO:0016762:xyloglucan:xyloglucosyl transferase activity:F", "GO:0010411:xyloglucan metabolic process:P", "GO:0042546:cell wall biogenesis:P"], "name": "XTH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016456": {"description": "Predicted cobalamin-independent methionine synthase, catalytic subunit", "go_ids": [], "go_terms": [], "name": "Met_Synthase_cat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016457": {"description": "Formylmethanofuran dehydrogenase, subunit B", "go_ids": ["GO:0015948", "GO:0018493"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0018493:formylmethanofuran dehydrogenase activity:F"], "name": "Formylmethanofuran_DH_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016458": {"description": "Uncharacterised conserved protein UCP005648, calcium-binding", "go_ids": [], "go_terms": [], "name": "UCP005648_Ca-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016460": {"description": "Coatomer beta subunit (COPB1)", "go_ids": ["GO:0005737", "GO:0006886"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006886:intracellular protein transport:P"], "name": "COPB1", "pathway_ids": ["R-SPO-6807878", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-SCE-6807878", "R-RNO-6811434", "R-SCE-6811434", "R-RNO-6807878", "R-DME-6798695", "R-SCE-6798695", "R-HSA-6807878", "R-BTA-6798695", "R-MMU-6807878", "R-DDI-6811434", "R-GGA-6798695", "R-MMU-6811434", "R-DME-6811434", "R-BTA-6807878", "R-HSA-6811434", "R-DDI-6807878", "R-DRE-6811434", "R-DRE-6798695", "R-DRE-6807878", "R-SPO-6811434", "R-MMU-6798695", "R-DME-6807878", "R-BTA-6811434", "R-RNO-6798695", "R-GGA-6811434", "R-GGA-6807878"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER 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"O-methyltransferase-like", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "COMT-like", "pathway_ids": ["R-DDI-209931", "R-HSA-209931", "R-RNO-209931", "R-MMU-209931", "R-BTA-209931"], "pathways": ["R-DDI-209931:r:Serotonin and melatonin biosynthesis", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-209931:r:Serotonin and melatonin biosynthesis", "R-BTA-209931:r:Serotonin and melatonin biosynthesis"], "type": "Family"}, "IPR016462": {"description": "Molybdate-dependent transcriptional regulator ModE", "go_ids": ["GO:0015689", "GO:0030151", "GO:0006355"], "go_terms": ["GO:0015689:molybdate ion transport:P", "GO:0030151:molybdenum ion binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "ModE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016463": {"description": "Electron transport complex, RnfB/RsxB, Proteobacteria", "go_ids": ["GO:0005886", "GO:0022900", "GO:0051536"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0022900:electron transport chain:P", "GO:0051536:iron-sulfur cluster binding:F"], "name": "RnfB/RsxB_Proteobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016464": {"description": "NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2", "go_ids": [], "go_terms": [], "name": "NADH_Ub_cplx-1_asu_su-2", "pathway_ids": ["R-HSA-611105", "R-MMU-9837999", "R-MMU-6799198", "R-BTA-9837999", "R-HSA-6799198", "R-MMU-611105", "R-HSA-9837999", "R-BTA-6799198", "R-BTA-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6799198:r:Complex I biogenesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR016466": {"description": "Methanogenesis marker 3 protein", "go_ids": [], "go_terms": [], "name": "Methan_mark_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016467": {"description": "DNA recombination and repair protein, RecA-like", "go_ids": [], "go_terms": [], "name": "DNA_recomb/repair_RecA-like", "pathway_ids": ["R-GGA-912446", "R-GGA-5685938", "R-HSA-5685942", "R-GGA-5685942", "R-HSA-5693616", "R-BTA-5685938", "R-HSA-9704646", "R-GGA-351433", "R-GGA-5693616", "R-GGA-265976", "R-MMU-5693616", "R-MMU-983231", "R-HSA-6796648", "R-HSA-8953750", "R-MMU-5685938", "R-DME-5693616", "R-BTA-912446", "R-CFA-5693568", "R-HSA-9709570", "R-HSA-912446", "R-BTA-5693616", "R-SCE-5693616", "R-SPO-5693616", "R-BTA-5693579", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-HSA-9701192", "R-BTA-5693568", "R-GGA-5693568", "R-HSA-983231", "R-HSA-9709603", "R-MMU-5685942", "R-MMU-912446", 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"PWY-7975", "PWY-7886", "PWY-8402", "R-HSA-163841", "R-MMU-163841"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation", "R-HSA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation"], "type": "Family"}, "IPR016478": {"description": "GTPase, MTG1", "go_ids": [], "go_terms": [], "name": "GTPase_MTG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016479": {"description": "tRNA/rRNA methyltransferase, YfiF-like", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "YfiF-like", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR016480": {"description": "Glucose translocase, bactoprenol-linked", "go_ids": [], "go_terms": [], "name": "Glc_translocase_bactprenl-link", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016481": {"description": "Transcription factor TFE, archaea", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "TF_E_archaea", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016482": {"description": "Protein transport protein SecG/Sec61-beta/Sbh", "go_ids": [], "go_terms": [], "name": "SecG/Sec61-beta/Sbh", "pathway_ids": ["R-HSA-1799339", "R-HSA-1236974", "R-MMU-9609523", "R-SCE-9609523", "R-HSA-9609523", "R-DDI-9609523", "R-SPO-9609523", "R-CFA-9609523"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CFA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Family"}, "IPR016483": {"description": "Uncharacterised conserved protein UCP006404, peptidase M50/CBS", "go_ids": [], "go_terms": [], "name": "UCP006404_Pept_M50_CBS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016484": {"description": "GTPase Der", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "GTPase_Der", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016486": {"description": "Uncharacterised conserved protein UCP006591, MJ1004 type", "go_ids": [], "go_terms": [], "name": "UCP006591_CBS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016487": {"description": "Sm-like protein Lsm6/SmF", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "Lsm6/sSmF", "pathway_ids": ["R-BTA-191859", "R-CEL-111367", "R-HSA-191859", "R-CEL-72165", "R-CEL-191859", "R-MMU-77588", "R-MMU-9770562", "R-BTA-77588", "R-HSA-73856", "R-DME-72163", "R-DDI-9770562", "R-CEL-73856", "R-DDI-72163", "R-DDI-111367", "R-DME-9770562", "R-DDI-73856", "R-MMU-430039", "R-CEL-9770562", "R-HSA-77588", "R-HSA-111367", "R-HSA-72165", "R-DME-73856", "R-CEL-72163", "R-HSA-9918481", "R-MMU-191859", "R-DDI-430039", "R-HSA-430039", "R-BTA-72163", "R-BTA-111367", "R-SPO-430039", "R-HSA-9770562", "R-BTA-72165", "R-MMU-72163", "R-SCE-430039", "R-MMU-73856", "R-BTA-73856", "R-HSA-9754678", "R-SPO-9770562", "R-HSA-72163", "R-DME-72165", "R-MMU-72165", "R-DDI-77588", "R-MMU-111367", "R-BTA-9770562", "R-DME-77588", "R-SPO-72163", "R-CEL-77588", "R-DME-111367"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-CEL-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-191859:r:snRNP Assembly", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-191859:r:snRNP Assembly", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-BTA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-DDI-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-DDI-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-191859:r:snRNP Assembly", "R-DDI-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-SPO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-BTA-9770562:r:mRNA Polyadenylation", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DME-111367:r:SLBP independent Processing of Histone Pre-mRNAs"], "type": "Family"}, "IPR016488": {"description": "NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6", "go_ids": [], "go_terms": [], "name": "NADH_Ub_cplx-1_asu_su-6", "pathway_ids": ["R-MMU-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105"], "pathways": ["R-MMU-6799198:r:Complex I biogenesis", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR016489": {"description": "BAPKO_0422-like", "go_ids": [], "go_terms": [], "name": "BAPKO_0422-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016490": {"description": "Transcriptional regulator, HTH, AF0396-type", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_HTH_AF0396-typ3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016491": {"description": "Septin", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "Septin", "pathway_ids": ["R-RNO-111457", "R-SPO-111457", "R-HSA-111469", "R-HSA-111457", "R-HSA-5687128", "R-BTA-5620912", "R-MMU-111457", "R-SCE-111457", "R-HSA-5620912", "R-RNO-5620912", "R-SPO-111469", "R-RNO-5687128", "R-MMU-5687128", "R-RNO-111469", "R-MMU-5620912", "R-MMU-111469"], "pathways": ["R-RNO-111457:r:Release of apoptotic factors from the mitochondria", "R-SPO-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-SCE-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SPO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response"], "type": "Family"}, "IPR016493": {"description": "Spore coat protein CotF", "go_ids": [], "go_terms": [], "name": "Spore_coat_CotF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016494": {"description": "5'-3' exoribonuclease 1", "go_ids": ["GO:0008409", "GO:0000956"], "go_terms": ["GO:0008409:5'-3' exonuclease activity:F", "GO:0000956:nuclear-transcribed mRNA catabolic process:P"], "name": "5_3_exoribonuclease_1", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-MMU-450513", "R-HSA-450513", "R-SCE-450513", "R-HSA-9918487", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Family"}, "IPR016495": {"description": "p53 negative regulator Mdm2/Mdm4", "go_ids": ["GO:0005634", "GO:0043066", "GO:0051726"], "go_terms": ["GO:0005634:nucleus:C", "GO:0043066:negative regulation of apoptotic process:P", "GO:0051726:regulation of cell cycle:P"], "name": "p53_neg-reg_MDM_2/4", "pathway_ids": ["R-MMU-3232142", "R-HSA-2559580", "R-DRE-3232142", "R-DRE-2559580", "R-HSA-5689880", "R-MMU-8941858", "R-DRE-69541", "R-HSA-2559585", "R-MMU-198323", "R-CFA-6804757", "R-MMU-6804756", "R-CFA-8941858", "R-DRE-2559585", "R-HSA-9766229", "R-MMU-69541", "R-DRE-8941858", "R-DRE-198323", "R-RNO-69541", "R-HSA-198323", "R-CFA-5689880", "R-CFA-69541", "R-MMU-5689880", "R-CFA-2559585", "R-HSA-9725370", "R-HSA-6804757", "R-CFA-6804760", "R-RNO-6804756", "R-MMU-6804760", "R-DRE-6804756", "R-CFA-9766229", "R-HSA-399719", "R-HSA-5674400", "R-HSA-8941858", "R-MMU-6804757", "R-HSA-6804760", "R-MMU-2559580", "R-RNO-6804760", "R-RNO-5689880", "R-HSA-3232142", "R-RNO-6804757", "R-DRE-9766229", "R-HSA-6804756", "R-RNO-2559580", "R-CFA-399719", "R-HSA-3232118", "R-CFA-6804756", "R-HSA-69541", "R-CFA-2559580", "R-MMU-9766229", "R-DRE-6804757", "R-MMU-399719", "R-MMU-2559585", "R-HSA-9768919", "R-RNO-2559585"], "pathways": ["R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-69541:r:Stabilization of p53", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-2559585:r:Oncogene Induced Senescence", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-69541:r:Stabilization of p53", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-69541:r:Stabilization of p53", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-CFA-5689880:r:Ub-specific processing proteases", "R-CFA-69541:r:Stabilization of p53", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CFA-2559585:r:Oncogene Induced Senescence", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-CFA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-9766229:r:Degradation of CDH1", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-DRE-9766229:r:Degradation of CDH1", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-69541:r:Stabilization of p53", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-9766229:r:Degradation of CDH1", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-RNO-2559585:r:Oncogene Induced Senescence"], "type": "Family"}, "IPR016496": {"description": "GTPase HflX", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "GTPase_HflX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016497": {"description": "Herpesvirus UL5", "go_ids": [], "go_terms": [], "name": "Herpes_UL5", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR016498": {"description": "Protein YzcX", "go_ids": [], "go_terms": [], "name": "YzcX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016499": {"description": "Nucleic acid binding protein, Rv2694c, predicted", "go_ids": [], "go_terms": [], "name": "NucleicA-bd_Rv2694c_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016500": {"description": "Uncharacterised conserved protein UCP006993", "go_ids": [], "go_terms": [], "name": "UCP006993", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016502": {"description": "Type II secretion system (T2SS) pilotin, S protein", "go_ids": [], "go_terms": [], "name": "T2SSS_2", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR016504": {"description": "Outer membrane protein YaiO", "go_ids": [], "go_terms": [], "name": "YaiO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016505": {"description": "Protein YopQ", "go_ids": [], "go_terms": [], "name": "YopQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016506": {"description": "Competence protein D, Pasteurellaceae", "go_ids": [], "go_terms": [], "name": "ComD_Pasteurellaceae", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016507": {"description": "Uncharacterised conserved protein UCP007061", "go_ids": [], "go_terms": [], "name": "UCP007061", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016508": {"description": "Uncharacterised conserved protein UCP007103", "go_ids": [], "go_terms": [], "name": "UCP007103", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016509": {"description": "Factor-induced gene 1 protein", "go_ids": [], "go_terms": [], "name": "Fig1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016510": {"description": "Cysteine protease S273R", "go_ids": ["GO:0004197", "GO:0019082"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0019082:viral protein processing:P"], "name": "VPRT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016511": {"description": "Uncharacterised conserved protein UCP007248", "go_ids": [], "go_terms": [], "name": "UCP007248", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016512": {"description": "Inner membrane YidI, enterobacteriaceae", "go_ids": [], "go_terms": [], "name": "IM_YidI_en", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016513": {"description": "Uncharacterized protein YagM", "go_ids": [], "go_terms": [], "name": "YagM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016514": {"description": "Fimbrial protein EcpA", "go_ids": [], "go_terms": [], "name": "EcpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016515": {"description": "Uncharacterised conserved protein UCP007407, Abi protease-like", "go_ids": [], "go_terms": [], "name": "UCP007407_Abi-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016516": {"description": "Uncharacterised conserved protein UCP07580", "go_ids": [], "go_terms": [], "name": "UCP07580", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016517": {"description": "Peptidase M11, autolysin", "go_ids": [], "go_terms": [], "name": "Peptidase_M11_autolysin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016518": {"description": "Alpha-L-fucosidase", "go_ids": ["GO:0004560"], "go_terms": ["GO:0004560:alpha-L-fucosidase activity:F"], "name": "Alpha-L-fucosidase", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Family"}, "IPR016520": {"description": "Uncharacterised conserved protein UCP007778", "go_ids": [], "go_terms": [], "name": "UCP007778", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016521": {"description": "RNA-processing, Lsm12", "go_ids": [], "go_terms": [], "name": "RNA-processing_Lsm12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016522": {"description": "Ribosome assembly protein RSM22, mitochondrial, budding yeast", "go_ids": [], "go_terms": [], "name": "RSM22_mit_bud", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016523": {"description": "Calcipressin-like protein", "go_ids": ["GO:0019722"], "go_terms": ["GO:0019722:calcium-mediated signaling:P"], "name": "Rcn1_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016524": {"description": "Ubiquitin-like-conjugating enzyme Atg10", "go_ids": ["GO:0019777", "GO:0006914"], "go_terms": ["GO:0019777:Atg12 transferase activity:F", "GO:0006914:autophagy:P"], "name": "Atg10", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis"], "type": "Family"}, "IPR016527": {"description": "Origin recognition complex subunit 4", "go_ids": ["GO:0000808", "GO:0003677", "GO:0005634", "GO:0006260"], "go_terms": ["GO:0000808:origin recognition complex:C", "GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0006260:DNA replication:P"], "name": "ORC4", "pathway_ids": ["R-DDI-68689", "R-RNO-68949", "R-HSA-68949", "R-SPO-176187", "R-RNO-68962", "R-SPO-68616", "R-BTA-68616", "R-MMU-68962", "R-HSA-113507", "R-BTA-68949", "R-MMU-68949", "R-RNO-176187", "R-DDI-68616", "R-HSA-68689", "R-SCE-68962", "R-BTA-68962", "R-BTA-176187", "R-SCE-68616", "R-HSA-68616", "R-BTA-68689", "R-RNO-68616", "R-DDI-68962", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-MMU-68689", "R-SPO-68962", "R-MMU-68616", "R-SPO-68949", "R-SCE-176187", "R-HSA-176187", "R-RNO-68689", "R-HSA-68867"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Family"}, "IPR016528": {"description": "Vacuolar protein sorting-associated protein 11", "go_ids": [], "go_terms": [], "name": "VPS11", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Family"}, "IPR016530": {"description": "Mediator of RNA polymerase II transcription subunit 22, Saccharomycetes", "go_ids": ["GO:0003712", "GO:0006357", "GO:0016592"], "go_terms": ["GO:0003712:transcription coregulator activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C"], "name": "Med22_Saccharomyce", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016531": {"description": "RNA polymerase I-specific transcription initiation factor Rrn6", "go_ids": ["GO:0006361", "GO:0070860"], "go_terms": ["GO:0006361:transcription initiation at RNA polymerase I promoter:P", "GO:0070860:RNA polymerase I core factor complex:C"], "name": "Rrn6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016532": {"description": "Mediator of RNA polymerase II transcription subunit 20", "go_ids": ["GO:0003712", "GO:0006357", "GO:0016592"], "go_terms": ["GO:0003712:transcription coregulator activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C"], "name": "Med20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016533": {"description": "Wound-induced protein 1/12, subgroup", "go_ids": [], "go_terms": [], "name": "Wound-induced_1/12_sub", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016534": {"description": "Vacuolar protein sorting-associated protein 16", "go_ids": ["GO:0006886", "GO:0007033"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0007033:vacuole organization:P"], "name": "VPS16", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Family"}, "IPR016535": {"description": "RFamide neuropeptide, ACEP-1", "go_ids": [], "go_terms": [], "name": "RFamide_neuropeptide_ACEP-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016537": {"description": "Uncharacterised conserved protein UCP008159, ABC-type", "go_ids": [], "go_terms": [], "name": "UCP008159_ABC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016538": {"description": "Uncharacterised conserved protein UCP008292", "go_ids": [], "go_terms": [], "name": "UCP008292", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016539": {"description": "Uncharacterised conserved protein UCP008315", "go_ids": [], "go_terms": [], "name": "UCP008315", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016540": {"description": "Uncharacterised conserved protein UCP008459", "go_ids": [], "go_terms": [], "name": "UCP008459", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016541": {"description": "Uncharacterised conserved protein UCP008505", "go_ids": [], "go_terms": [], "name": "UCP008505", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016542": {"description": "Phosphatidylinositol N-acetylglucosaminyltransferase, GPI19/PIG-P subunit", "go_ids": ["GO:0006506", "GO:0017176"], "go_terms": ["GO:0006506:GPI anchor biosynthetic process:P", "GO:0017176:phosphatidylinositol N-acetylglucosaminyltransferase activity:F"], "name": "PIG-P_GPI19", "pathway_ids": ["R-HSA-162710", "R-MMU-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR016543": {"description": "Mitochondria fission 1 protein", "go_ids": ["GO:0000266"], "go_terms": ["GO:0000266:mitochondrial fission:P"], "name": "Fis1", "pathway_ids": ["R-CEL-9603798", "R-SCE-9603798", "R-MMU-9603798", "R-DME-9603798", "R-HSA-9603798", "R-BTA-9603798", "R-SPO-9603798", "R-RNO-9603798"], "pathways": ["R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-DME-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import"], "type": "Family"}, "IPR016544": {"description": "N-glycosylase/DNA lyase", "go_ids": ["GO:0000702", "GO:0003906", "GO:0006284"], "go_terms": ["GO:0000702:oxidized base lesion DNA N-glycosylase activity:F", "GO:0003906:DNA-(apurinic or apyrimidinic site) endonuclease activity:F", "GO:0006284:base-excision repair:P"], "name": "AGOG", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Family"}, "IPR016545": {"description": "Uncharacterised conserved protein UCP009120, proteasome-type protease, Sll0069", "go_ids": [], "go_terms": [], "name": "UCP009120_prtse", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016546": {"description": "Maltodextrose utilization protein MalA", "go_ids": [], "go_terms": [], "name": "Maltodextrose_util_MalA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016547": {"description": "Antitoxin TacA", "go_ids": [], "go_terms": [], "name": "TacA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016548": {"description": "Uncharacterised conserved protein UCP009180", "go_ids": [], "go_terms": [], "name": "UCP009180", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016549": {"description": "Uncharacterised conserved protein UCP009193", "go_ids": [], "go_terms": [], "name": "UCP009193", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016550": {"description": "Guanidinoacetate N-methyltransferase", "go_ids": ["GO:0030731"], "go_terms": ["GO:0030731:guanidinoacetate N-methyltransferase activity:F"], "name": "GuanidinoAc_N-MeTrfase", "pathway_ids": ["R-HSA-71288", "R-HSA-8986944", "R-BTA-71288", "R-DRE-71288", "R-MMU-71288", "R-RNO-71288", "R-XTR-71288"], "pathways": ["R-HSA-71288:r:Creatine metabolism", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-BTA-71288:r:Creatine metabolism", "R-DRE-71288:r:Creatine metabolism", "R-MMU-71288:r:Creatine metabolism", "R-RNO-71288:r:Creatine metabolism", "R-XTR-71288:r:Creatine metabolism"], "type": "Family"}, "IPR016551": {"description": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, metazoa", "go_ids": ["GO:0006120"], "go_terms": ["GO:0006120:mitochondrial electron transport, NADH to ubiquinone:P"], "name": "Ndufb8_metazoa", "pathway_ids": ["R-HSA-611105", "R-HSA-1268020", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-1268020", "R-MMU-1268020", "R-MMU-611105", "R-BTA-6799198", "R-BTA-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-1268020:r:Mitochondrial protein import", "R-MMU-1268020:r:Mitochondrial protein import", "R-MMU-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR016553": {"description": "Protein tyrosine phosphatase receptor type C-associated protein", "go_ids": [], "go_terms": [], "name": "PTPRCAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016554": {"description": "Runt-related transcription factor RUNX", "go_ids": [], "go_terms": [], "name": "TF_Runt-rel_RUNX", "pathway_ids": ["R-HSA-2032785", "R-HSA-8939256", "R-HSA-9942503", "R-HSA-8941856", "R-HSA-8951430", "R-MMU-8941858", "R-HSA-8936459", "R-RNO-8934593", "R-MMU-8951671", "R-MMU-8939246", "R-HSA-8951911", "R-MMU-8939247", "R-MMU-8934593", "R-HSA-8952158", "R-MMU-8939245", "R-RNO-8939246", "R-RNO-8939243", "R-RNO-8936459", "R-RNO-9018519", "R-MMU-8939236", "R-HSA-1912408", "R-HSA-8939236", "R-HSA-8941333", "R-HSA-8939245", "R-HSA-8877330", "R-RNO-8939245", "R-HSA-8941855", "R-RNO-549127", "R-HSA-9616222", "R-HSA-8878166", "R-MMU-8877330", "R-RNO-8939247", "R-MMU-8951430", "R-HSA-8941326", "R-HSA-9018519", "R-MMU-8941855", "R-HSA-8951936", "R-MMU-8931987", "R-MMU-8936459", "R-HSA-8939247", "R-HSA-8931987", "R-MMU-8951936", "R-HSA-8951671", "R-HSA-8941858", "R-HSA-8949275", "R-RNO-8931987", "R-HSA-8934593", "R-MMU-8939243", "R-HSA-8941332", "R-MMU-9018519", "R-RNO-8939236", "R-HSA-8939902", "R-HSA-8939243", "R-HSA-8935964", "R-RNO-8877330", "R-HSA-9692916", "R-MMU-8941856", "R-HSA-549127", "R-HSA-4411364", "R-HSA-8939246", "R-MMU-549127", "R-HSA-8939242", "R-HSA-8940973", "R-HSA-8941284"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-8951430:r:RUNX3 regulates WNT signaling", "R-MMU-8941858:r:Regulation of RUNX3 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differentiation and platelet function", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8941333:r:RUNX2 regulates genes involved in differentiation of myeloid cells", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-549127:r:SLC-mediated transport of organic cations", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-MMU-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-MMU-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-8949275:r:RUNX3 Regulates Immune Response and Cell Migration", "R-RNO-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-RNO-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-549127:r:SLC-mediated transport of organic cations", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation"], "type": "Family"}, "IPR016555": {"description": "Phospholipase D, eukaryotic type", "go_ids": ["GO:0004630", "GO:0006654", "GO:0035556"], "go_terms": ["GO:0004630:D-type glycerophospholipase activity:F", "GO:0006654:phosphatidic acid biosynthetic process:P", "GO:0035556:intracellular signal transduction:P"], "name": "PLipase_D_euk", "pathway_ids": ["PWY-3561", "PWY-7039", "R-HSA-6798695", "R-SPO-6798695", "R-SPO-2029485", "R-RNO-1483166", "R-MMU-8980692", "R-SCE-2029485", "R-RNO-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-HSA-2029485", "R-RNO-9013149", "R-MMU-9013404", "R-HSA-1483166", "R-HSA-1483148", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-1483166", "R-HSA-9013149", "R-HSA-8980692", "R-RNO-2029485", "R-SCE-8980692", "R-SPO-1483166", "R-HSA-9013148", "R-MMU-2029485", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-MMU-6798695", "R-MMU-9013149", "R-SCE-1483166", "R-RNO-6798695"], "pathways": ["PWY-3561:t:choline biosynthesis III", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-1483166:r:Synthesis of PA", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1483148:r:Synthesis of PG", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-1483166:r:Synthesis of PA", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-SCE-1483166:r:Synthesis of PA", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR016557": {"description": "Cyclic 2,3-diphosphoglycerate synthetase", "go_ids": ["GO:0005737", "GO:0006094", "GO:0036356"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006094:gluconeogenesis:P", "GO:0036356:cyclic 2,3-diphosphoglycerate synthetase activity:F"], "name": "CpgS", "pathway_ids": ["PWY-8098"], "pathways": ["PWY-8098:t:cyclic 2,3-bisphosphoglycerate biosynthesis"], "type": "Family"}, "IPR016558": {"description": "DNA primase, large subunit, eukaryotic", "go_ids": [], "go_terms": [], "name": "DNA_primase_lsu_euk", "pathway_ids": ["R-MMU-174430", "R-CEL-69091", "R-RNO-68962", "R-CEL-68962", "R-SCE-69091", "R-CEL-113501", "R-CEL-69166", "R-DME-113501", "R-RNO-69183", "R-DDI-68952", "R-RNO-69166", "R-DME-68962", "R-DDI-68962", "R-CEL-69183", "R-SPO-69091", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-RNO-68952", "R-RNO-174411", "R-SCE-68952", "R-SPO-69166", "R-HSA-113501", "R-SCE-69183", "R-HSA-68952", "R-DDI-113501", "R-DDI-69091", "R-MMU-68962", "R-DDI-69183", "R-RNO-174430", "R-SPO-69183", "R-HSA-174430", "R-MMU-113501", "R-DME-69091", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-SCE-68962", "R-SCE-113501", "R-DDI-69166", "R-RNO-69091", "R-HSA-9710421", "R-MMU-68952", "R-RNO-113501", "R-SPO-113501", "R-SPO-68952", 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"IPR016570": {"description": "Uncharacterised conserved protein UCP010361, membrane", "go_ids": [], "go_terms": [], "name": "UCP010361", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016571": {"description": "Spore coat assembly protein CotJB", "go_ids": [], "go_terms": [], "name": "Spore_coat_assembly_CotJB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016572": {"description": "Uncharacterised conserved protein UCP010611", "go_ids": [], "go_terms": [], "name": "UCP010611", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016573": {"description": "Meiosis-specific protein Hop1", "go_ids": ["GO:0051598", "GO:0007130", "GO:0007129", "GO:0000400"], "go_terms": ["GO:0051598:meiotic recombination checkpoint signaling:P", "GO:0007130:synaptonemal complex assembly:P", "GO:0007129:homologous chromosome pairing at meiosis:P", "GO:0000400:four-way junction DNA binding:F"], "name": "Hop1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016574": {"description": "Nicalin", "go_ids": ["GO:0016020", "GO:0009966"], "go_terms": ["GO:0016020:membrane:C", "GO:0009966:regulation of signal transduction:P"], "name": "Nicalin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016575": {"description": "Bardet-Biedl syndrome 7 protein", "go_ids": ["GO:1905515", "GO:0034464"], "go_terms": ["GO:1905515:non-motile cilium assembly:P", "GO:0034464:BBSome:C"], "name": "Bardet-Biedl_syndrome_7_prot", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Family"}, "IPR016576": {"description": "Large ribosomal subunit protein mL63", "go_ids": ["GO:0005761"], "go_terms": ["GO:0005761:mitochondrial ribosome:C"], "name": "Ribosomal_mL63", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-DRE-5389840", "R-BTA-9937383", "R-DRE-5419276"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR016577": {"description": "Adenylate cyclase, type 10", "go_ids": ["GO:0000287", "GO:0004016", "GO:0006171", "GO:0007283"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0004016:adenylate cyclase activity:F", "GO:0006171:cAMP biosynthetic process:P", "GO:0007283:spermatogenesis:P"], "name": "Adenylate_cyclase_typ10", "pathway_ids": ["R-HSA-5610787", "R-MMU-5610787", "R-RNO-5610787"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-5610787:r:Hedgehog 'off' state"], "type": "Family"}, "IPR016578": {"description": "SODIUM POTASSIUM ROOT DEFECTIVE 2/3", "go_ids": [], "go_terms": [], "name": "NAKR2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016579": {"description": "Synaptogyrin", "go_ids": [], "go_terms": [], "name": "Synaptogyrin", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-DME-6798695", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR016580": {"description": "HUS1", "go_ids": ["GO:0030896", "GO:0005730", "GO:0000077"], "go_terms": ["GO:0030896:checkpoint clamp complex:C", "GO:0005730:nucleolus:C", "GO:0000077:DNA damage checkpoint signaling:P"], "name": "HUS1", "pathway_ids": ["R-MMU-69473", "R-SPO-176187", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-MMU-5685938", "R-HSA-5693616", "R-HSA-69473", "R-MMU-176187", "R-MMU-6804756", "R-HSA-176187", "R-HSA-5685938", "R-MMU-5693607", "R-DME-176187"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Family"}, "IPR016581": {"description": "CRISPR-associated protein Cas7, subtype I-B/Tneap, bacterial", "go_ids": ["GO:0051607"], "go_terms": ["GO:0051607:defense response to virus:P"], "name": "Cas7/Cst2/DevR_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016582": {"description": "D-(-)-3-hydroxybutyrate oligomer hydrolase, putative", "go_ids": ["GO:0005576", "GO:0019605", "GO:0047989"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019605:butyrate metabolic process:P", "GO:0047989:hydroxybutyrate-dimer hydrolase activity:F"], "name": "OHBut_olig_hydro_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016583": {"description": "Uncharacterised conserved protein UCP011452, HNH endonuclease domain-type", "go_ids": [], "go_terms": [], "name": "UCP011452_HNH_endonucl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016584": {"description": "Methyltransferase VrtF-like", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "MeTrfase_VrtF", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR016585": {"description": "Glycine/sarcosine/betaine reductase, component B, fused alpha/beta", "go_ids": ["GO:0050485"], "go_terms": ["GO:0050485:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor:F"], "name": "Gly/sarc/bet_Rdtase_B_asu/bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016586": {"description": "Mitochondrial transcription factor Mtf1", "go_ids": ["GO:0006391", "GO:0005739", "GO:0034246"], "go_terms": ["GO:0006391:transcription initiation at mitochondrial promoter:P", "GO:0005739:mitochondrion:C", "GO:0034246:mitochondrial transcription factor activity:F"], "name": "Mtf1", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-SCE-163282"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-SCE-163282:r:Mitochondrial transcription initiation"], "type": "Family"}, "IPR016587": {"description": "DNA damage checkpoint control protein Rad17", "go_ids": ["GO:0000077", "GO:0006302", "GO:0030896", "GO:0003684", "GO:0003690", "GO:0007131"], "go_terms": ["GO:0000077:DNA damage checkpoint signaling:P", "GO:0006302:double-strand break repair:P", "GO:0030896:checkpoint clamp complex:C", "GO:0003684:damaged DNA binding:F", "GO:0003690:double-stranded DNA binding:F", "GO:0007131:reciprocal meiotic recombination:P"], "name": "Rad17", "pathway_ids": ["R-SCE-176187"], "pathways": ["R-SCE-176187:r:Activation of ATR in response to replication stress"], "type": "Family"}, "IPR016588": {"description": "Replication factor A protein 3, Saccharomycetes", "go_ids": ["GO:0006260", "GO:0006281", "GO:0006310", "GO:0005634", "GO:0003677"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0005634:nucleus:C", "GO:0003677:DNA binding:F"], "name": "Rfp3_Saccharomycetes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016589": {"description": "tRNA-splicing endonuclease, SEN2 subunit", "go_ids": ["GO:0000213", "GO:0000214", "GO:0006388"], "go_terms": ["GO:0000213:tRNA-intron lyase activity:F", "GO:0000214:tRNA-intron endonuclease complex:C", "GO:0006388:tRNA splicing, via endonucleolytic cleavage and ligation:P"], "name": "tRNA_splic_SEN2", "pathway_ids": ["PWY-7803", "PWY-6689", "R-HSA-6784531"], "pathways": ["PWY-7803:t:tRNA splicing II", "PWY-6689:t:tRNA splicing I", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR016590": {"description": "Rhamnogalacturonase B", "go_ids": ["GO:0005975", "GO:0016837"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016837:carbon-oxygen lyase activity, acting on polysaccharides:F"], "name": "Rhamnogalacturonase_B", "pathway_ids": ["PWY-6771"], "pathways": ["PWY-6771:t:rhamnogalacturonan type I degradation II (bacteria)"], "type": "Family"}, "IPR016591": {"description": "Suppressor of fused, eukaryotic", "go_ids": ["GO:0008134"], "go_terms": ["GO:0008134:transcription factor binding:F"], "name": "Suppressor_of_fused_euk", "pathway_ids": ["R-HSA-5610780", "R-MMU-5610780", "R-HSA-5610785", "R-MMU-5632684", "R-MMU-5610785", "R-HSA-5610787", "R-MMU-5610787", "R-HSA-5610783", "R-HSA-5632684"], "pathways": ["R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-5632684:r:Hedgehog 'on' state"], "type": "Family"}, "IPR016592": {"description": "Nibrin", "go_ids": ["GO:0030870", "GO:0005634", "GO:0006281", "GO:0000723", "GO:0007093", "GO:0006974"], "go_terms": ["GO:0030870:Mre11 complex:C", "GO:0005634:nucleus:C", "GO:0006281:DNA repair:P", "GO:0000723:telomere maintenance:P", "GO:0007093:mitotic cell cycle checkpoint signaling:P", "GO:0006974:DNA damage response:P"], "name": "Nibrin_met", "pathway_ids": ["R-DRE-5693607", "R-HSA-5685942", "R-MMU-5693571", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5693565", "R-GGA-351433", "R-RNO-5685939", "R-MMU-6804756", "R-HSA-5693565", "R-DRE-5685939", "R-RNO-5693548", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-5693565", "R-MMU-69473", "R-DRE-5693568", "R-DRE-5693571", "R-HSA-9709570", "R-HSA-5693607", "R-DRE-2559586", "R-GGA-351444", "R-RNO-5685938", "R-HSA-912446", "R-MMU-5685939", "R-RNO-6804756", "R-MMU-5693568", "R-GGA-351442", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-RNO-2559586", "R-GGA-217106", "R-MMU-5693548", "R-RNO-5693579", "R-HSA-69473", "R-MMU-2559586", "R-RNO-5693607", "R-HSA-9709603", "R-DRE-5685942", "R-MMU-5685942", "R-RNO-5693571", "R-HSA-5685939", "R-RNO-69473", "R-RNO-5685942", "R-DRE-5693548", "R-HSA-5693571", "R-HSA-6804756", "R-HSA-9704331", "R-DRE-69473", "R-RNO-5693568", "R-DRE-5693616", "R-DRE-5693565", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-HSA-5693579", "R-HSA-2559586", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Family"}, "IPR016593": {"description": "Adenovirus 41, E3-31.6kDa", "go_ids": [], "go_terms": [], "name": "Adenovirus-41_E3-31.6kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016594": {"description": "Bacteriophage T4 Inh", "go_ids": [], "go_terms": [], "name": "Inh_T4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016595": {"description": "Surface-adhesin protein E, Pasteurellaceae", "go_ids": [], "go_terms": [], "name": "Adhesin_E_Pasteurellaceae", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016596": {"description": "Protein of unknown function UCP012335", "go_ids": [], "go_terms": [], "name": "UCP012335", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016597": {"description": "Uncharacterised conserved protein UCP012359", "go_ids": [], "go_terms": [], "name": "UCP012359", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016599": {"description": "Uncharacterised conserved protein UCP012569", "go_ids": [], "go_terms": [], "name": "UCP012569", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016600": {"description": "Uncharacterised conserved protein UCP012611", "go_ids": [], "go_terms": [], "name": "UCP012611", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016601": {"description": "Uncharacterised conserved protein UCP012637", "go_ids": [], "go_terms": [], "name": "UCP012637", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016602": {"description": "Uncharacterised conserved protein UCP012666", "go_ids": [], "go_terms": [], "name": "UCP012666", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016604": {"description": "Uncharacterised conserved protein UCP012886", "go_ids": [], "go_terms": [], "name": "UCP012886", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016605": {"description": "High-affinity nitrate transporter", "go_ids": ["GO:0015706", "GO:0010167"], "go_terms": ["GO:0015706:nitrate transmembrane transport:P", "GO:0010167:response to nitrate:P"], "name": "Transptr_NO3_Nar2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016606": {"description": "Uncharacterised conserved protein UCP012943, magnoliopsida", "go_ids": [], "go_terms": [], "name": "UCP012943_magno", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016607": {"description": "Protein SCAI, metazoan/viridiplantae", "go_ids": ["GO:0006351", "GO:0003714"], "go_terms": ["GO:0006351:DNA-templated transcription:P", "GO:0003714:transcription corepressor activity:F"], "name": "SCAI_metazoan/Viridiplantae", "pathway_ids": ["R-HSA-5663220", "R-MMU-5663220"], "pathways": ["R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR016608": {"description": "PR domain zinc finger protein 1", "go_ids": ["GO:0001227", "GO:0048869"], "go_terms": ["GO:0001227:DNA-binding transcription repressor activity, RNA polymerase II-specific:F", "GO:0048869:cellular developmental process:P"], "name": "PRDM1", "pathway_ids": ["R-HSA-9701898", "R-HSA-6804754", "R-HSA-9827857"], "pathways": ["R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-6804754:r:Regulation of TP53 Expression", "R-HSA-9827857:r:Specification of primordial germ cells"], "type": "Family"}, "IPR016609": {"description": "Pleckstrin homology domain protein Opy1", "go_ids": [], "go_terms": [], "name": "Opy1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016610": {"description": "Exonuclease V, Saccharomyces", "go_ids": ["GO:0036297", "GO:0005739", "GO:0045145"], "go_terms": ["GO:0036297:interstrand cross-link repair:P", "GO:0005739:mitochondrion:C", "GO:0045145:single-stranded DNA 5'-3' DNA exonuclease activity:F"], "name": "Exo5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016611": {"description": "Mitochondrial intermembrane space cysteine motif-containing protein Mix14", "go_ids": [], "go_terms": [], "name": "Mix14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016612": {"description": "Mediator complex, subunit Med6, fungi", "go_ids": ["GO:0003712", "GO:0006357", "GO:0016592"], "go_terms": ["GO:0003712:transcription coregulator activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C"], "name": "Mediator_Med6_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016613": {"description": "Increased recombination centres protein 19, saccharomycetes", "go_ids": ["GO:0030437"], "go_terms": ["GO:0030437:ascospore formation:P"], "name": "Irc19_saccharomycetes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016614": {"description": "Mitochondrial holo-[acyl-carrier-protein] synthase Ppt2", "go_ids": ["GO:0005739", "GO:0008897"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0008897:holo-[acyl-carrier-protein] synthase activity:F"], "name": "PPTase_2", "pathway_ids": ["PWY-6012", "PWY-6289"], "pathways": ["PWY-6012:t:acyl carrier protein metabolism", "PWY-6289:t:petrobactin biosynthesis"], "type": "Family"}, "IPR016615": {"description": "Ubiquitin thioesterase Otubain", "go_ids": ["GO:0016579", "GO:0016787"], "go_terms": ["GO:0016579:protein deubiquitination:P", "GO:0016787:hydrolase activity:F"], "name": "Otubain", "pathway_ids": ["R-MMU-5689880", "R-DME-5689896", "R-HSA-5689896", "R-HSA-5689880", "R-RNO-5689896", "R-MMU-5689896", "R-CEL-5689896", "R-DME-5689880", "R-RNO-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-DME-5689880:r:Ub-specific processing proteases", "R-RNO-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR016616": {"description": "Bardet-Biedl syndrome 2 protein", "go_ids": ["GO:1905515", "GO:0034464"], "go_terms": ["GO:1905515:non-motile cilium assembly:P", "GO:0034464:BBSome:C"], "name": "Bardet-Biedl_syndrome_2_prot", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922", "R-DRE-5620922", "R-RNO-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Family"}, "IPR016617": {"description": "Armadillo repeat-containing protein 1", "go_ids": [], "go_terms": [], "name": "ARMC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016618": {"description": "Uncharacterised conserved protein UCP014422", "go_ids": [], "go_terms": [], "name": "UCP014422", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016619": {"description": "Uncharacterised conserved protein UCP014439, ACT", "go_ids": [], "go_terms": [], "name": "UCP014439_ACT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016620": {"description": "CRISPR system ring nuclease SSO1393", "go_ids": [], "go_terms": [], "name": "SSO1393", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016621": {"description": "Uncharacterised conserved protein UCP014543", "go_ids": [], "go_terms": [], "name": "UCP014543", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016622": {"description": "Bacteriophage SP-beta, YorJ", "go_ids": [], "go_terms": [], "name": "Phage_SP-beta_YorJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016624": {"description": "Uncharacterised conserved protein UCP014753", "go_ids": [], "go_terms": [], "name": "UCP014753", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016625": {"description": "Uncharacterised conserved protein UCP014872, subtilisin-related", "go_ids": [], "go_terms": [], "name": "UCP014872_subtilisin-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016626": {"description": "Uncharacterised conserved protein UCP014897, archaea", "go_ids": [], "go_terms": [], "name": "UCP014897_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016627": {"description": "Uncharacterised conserved protein UCP015013", "go_ids": [], "go_terms": [], "name": "UCP015013", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016628": {"description": "ATPase, SAG2001, predicted", "go_ids": [], "go_terms": [], "name": "ATPase_SAG2001_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016629": {"description": "TATA box-binding protein-associated factor RNA polymerase I subunit A, chordata", "go_ids": ["GO:0000120", "GO:0006360"], "go_terms": ["GO:0000120:RNA polymerase I transcription regulator complex:C", "GO:0006360:transcription by RNA polymerase I:P"], "name": "RNA_pol_I_TAF1A/TAFI48_chr", "pathway_ids": ["R-MMU-5250924", "R-MMU-73762", "R-HSA-73772", "R-HSA-73863", "R-HSA-427359", "R-RNO-73772", "R-HSA-5250924", "R-MMU-73863", "R-HSA-427413", "R-MMU-73772", "R-RNO-5250924", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762"], "pathways": ["R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Family"}, "IPR016630": {"description": "Uncharacterised conserved protein UCP015278", "go_ids": [], "go_terms": [], "name": "UCP015278", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016631": {"description": "Regulatory, RpfE", "go_ids": [], "go_terms": [], "name": "Regulatory_RpfE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016632": {"description": "Conserved oligomeric Golgi complex subunit 8, Metazoal and Viridiplantae", "go_ids": ["GO:0017119"], "go_terms": ["GO:0017119:COG complex:C"], "name": "COG8_Metazoal_Plant", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-HSA-6807878", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR016633": {"description": "Protein-arginine rhamnosyltransferase EarP", "go_ids": ["GO:0106361"], "go_terms": ["GO:0106361:protein-arginine rhamnosyltransferase activity:F"], "name": "EarP", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides 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repressor CapW-like", "go_ids": [], "go_terms": [], "name": "CapW-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016635": {"description": "Adaptor protein complex, sigma subunit", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "AP_complex_ssu", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-HSA-2132295", "R-SPO-437239", "R-SCE-8856828", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-432722", "R-HSA-9918485", "R-MMU-5099900", "R-BTA-416993", "R-DDI-437239", "R-RNO-8964038", "R-DDI-8856825", "R-SPO-8964038", "R-SCE-432720", "R-DDI-8866427", "R-SPO-8856825", "R-MMU-2132295", "R-MMU-8964038", "R-RNO-177504", "R-DDI-8856828", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-HSA-5140745", "R-MMU-432720", "R-RNO-5099900", "R-HSA-432722", "R-SCE-8964038", "R-DDI-8964038", "R-RNO-8866427", "R-BTA-2132295", "R-SPO-432720", "R-MMU-416993", "R-BTA-8856828", "R-HSA-416993", "R-MMU-437239", "R-RNO-2132295", "R-RNO-8856825", "R-RNO-437239", "R-BTA-5099900", "R-BTA-432720", "R-HSA-432720", "R-DDI-432720", "R-HSA-437239", "R-HSA-5099900", "R-HSA-167590", "R-HSA-9679191", "R-SPO-8856828", "R-MMU-5140745", "R-BTA-177504", "R-HSA-164940", "R-HSA-177504", "R-HSA-8866427", "R-BTA-8856825", "R-BTA-8964038", "R-HSA-8856825", "R-HSA-3928665", "R-MMU-8866427", "R-MMU-177504", "R-SCE-437239", "R-SCE-8856825", "R-SPO-8866427", "R-BTA-432722", "R-BTA-5140745", "R-SCE-8866427", "R-HSA-8964038", "R-RNO-416993", "R-HSA-182218"], "pathways": ["R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SPO-437239:r:Recycling pathway of L1", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", 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"R-CEL-8951664", "R-SPO-350562", "R-HSA-5358346", "R-DDI-8854050", "R-HSA-6798695", "R-DME-5689880", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-MMU-5607764", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-DME-8951664", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-HSA-202424", "R-DDI-1236978", "R-DDI-8951664", "R-DDI-5632684", "R-MMU-8951664", "R-DME-8939902", "R-RNO-174154", "R-CEL-382556", "R-CEL-5689603", "R-HSA-4641257", "R-RNO-202424", "R-MMU-9929491", "R-MMU-9929356", "R-HSA-174113", "R-DME-4608870", "R-RNO-5607761", "R-SCE-5668541", "R-RNO-9929356", "R-DDI-174154", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-HSA-69481", "R-DME-9762114", "R-CEL-4641258", "R-DDI-5658442", "R-DDI-8948751", "R-HSA-8941858", "R-HSA-5678895", "R-HSA-9755511", "R-RNO-9931269", "R-DME-202424", "R-CEL-9929491", "R-HSA-4641258", "R-RNO-8939236", "R-SPO-5689603", "R-DME-9755511", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-HSA-1169091", "R-CEL-69017", "R-HSA-4608870", "R-HSA-5658442", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-MMU-6798695", "R-DME-5610785", "R-RNO-2467813", "R-HSA-5689603", "R-DME-5607764", "R-RNO-983168", "R-DME-209406", "R-DME-2871837", "R-DME-450408", "R-DME-8941858", "R-SPO-6798695", "R-MMU-5610780", "R-HSA-187577", "R-DME-1169091", "R-DME-9954709", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-MMU-350562", "R-DDI-75815", "R-MMU-69601", "R-DME-195253", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-DME-5689603", "R-MMU-5658442", "R-RNO-8852276", "R-MMU-5689603", "R-HSA-174084", "R-DME-5607761", "R-DME-216167", "R-MMU-4608870", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-DDI-69017", "R-RNO-9907900", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-RNO-9929491", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-DME-538864", "R-SCE-9907900", "R-DDI-983168", "R-HSA-5668541", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-RNO-5607764", "R-RNO-8941858", "R-DDI-349425", "R-RNO-1169091", "R-RNO-5658442", "R-HSA-5687128", "R-HSA-69017", "R-RNO-9766229", "R-RNO-5610785", "R-MMU-983168", "R-DDI-450408", "R-DME-432395", "R-CEL-350562", "R-MMU-1236978", "R-HSA-350562", "R-DDI-174178", "R-CEL-4641257", "R-DME-68867", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-HSA-174178", "R-HSA-9020702", "R-RNO-8948751", "R-HSA-9604323", "R-RNO-5668541", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-8951664", "R-MMU-174154", "R-HSA-5689880", "R-HSA-9010553", "R-MMU-69017", "R-CEL-195253", "R-CEL-8941858", "R-MMU-9020702", "R-RNO-5687128", "R-RNO-382556", "R-HSA-75815", "R-MMU-8948751", "R-DME-5658442", "R-DME-8948751", "R-MMU-69481", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-CEL-1234176", "R-DDI-9929491", "R-MMU-5668541", "R-DME-2467813", "R-RNO-8854050", "R-HSA-8854050", "R-DME-5676590"], "pathways": ["R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-4641258:r:Degradation of DVL", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-4641258:r:Degradation of DVL", "R-RNO-8951664:r:Neddylation", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9766229:r:Degradation of CDH1", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-RNO-69481:r:G2/M Checkpoints", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-9907900:r:Proteasome assembly", "R-MMU-68949:r:Orc1 removal from chromatin", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-4641257:r:Degradation of AXIN", "R-DME-9907900:r:Proteasome assembly", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-5689603:r:UCH proteinases", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5632684:r:Hedgehog 'on' state", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-432626:r:Circadian Clock pathway", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8951664:r:Neddylation", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-DDI-5632684:r:Hedgehog 'on' state", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CEL-5689603:r:UCH proteinases", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-4641258:r:Degradation of DVL", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DME-202424:r:Downstream TCR signaling", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-5689603:r:UCH proteinases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5689603:r:UCH proteinases", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-5689603:r:UCH proteinases", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-5689603:r:UCH proteinases", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9907900:r:Proteasome assembly", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", 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"R-SPO-6807505", "R-DDI-73776", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-HSA-167162", "R-HSA-167161", "R-DDI-6807505", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-HSA-73779", "R-DDI-674695", "R-HSA-75953", "R-SCE-674695", "R-SPO-73779", "R-MMU-73776", "R-DDI-76042", "R-HSA-76042", "R-HSA-674695", "R-DDI-75953", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-SPO-73776", "R-SPO-75953", "R-SCE-73776"], "pathways": ["R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-674695:r:RNA Polymerase II 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"PWY-6906:t:chitin derivatives degradation", "R-SCE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SPO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SSC-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine"], "type": "Family"}, "IPR016658": {"description": "DNA primase LEF1", "go_ids": [], "go_terms": [], "name": "DNA_primase_LEF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016659": {"description": "Transcription factor II-I", "go_ids": ["GO:0006366"], "go_terms": ["GO:0006366:transcription by RNA polymerase II:P"], "name": "TF_II-I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016660": {"description": "Kinase associated protein phosphatase", "go_ids": ["GO:0004721"], "go_terms": ["GO:0004721:phosphoprotein phosphatase activity:F"], "name": "Kinase_assoc_Pase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016661": {"description": "Prefoldin, subunit 4", "go_ids": ["GO:0006457", "GO:0016272"], "go_terms": ["GO:0006457:protein folding:P", "GO:0016272:prefoldin complex:C"], "name": "PFDN4", "pathway_ids": ["R-HSA-389957"], "pathways": ["R-HSA-389957:r:Prefoldin mediated transfer of substrate to CCT/TriC"], "type": "Family"}, "IPR016662": {"description": "Acyl-CoA thioesterase, long chain", "go_ids": ["GO:0006637", "GO:0016790"], "go_terms": ["GO:0006637:acyl-CoA metabolic process:P", "GO:0016790:thiolester hydrolase activity:F"], "name": "Acyl-CoA_thioEstase_long-chain", "pathway_ids": ["PWY-7723", "PWY-6733", "PWY-1121", "PWY-321", "PWY-5996", "PWY-5972", "R-MMU-9837999", "R-MMU-193368", "R-HSA-9918432", "R-HSA-193368", "R-MMU-9033241", "R-RNO-9837999", "R-RNO-9033241", "R-MMU-159418", "R-RNO-159418", "R-RNO-77289", "R-HSA-390247", "R-MMU-77289", "R-RNO-193368", "R-MMU-390247", "R-HSA-159418", "R-HSA-9837999", "R-HSA-9033241", "R-HSA-77289"], "pathways": ["PWY-7723:t:bacterial bioluminescence", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-1121:t:suberin monomers biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-5996:t:oleate biosynthesis II (animals and fungi)", "PWY-5972:t:stearate biosynthesis I (animals)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-159418:r:Recycling of bile acids and salts", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 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"R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR016669": {"description": "Interferon alpha/beta receptor 1", "go_ids": ["GO:0004904", "GO:0019221"], "go_terms": ["GO:0004904:interferon receptor activity:F", "GO:0019221:cytokine-mediated signaling pathway:P"], "name": "Interferon_alpha/beta_rcpt-1", "pathway_ids": ["R-HSA-9833109", "R-HSA-9705671", "R-HSA-909733", "R-BTA-909733", "R-HSA-912694", "R-HSA-9679191", "R-MMU-909733", "R-MMU-912694", "R-BTA-912694"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-BTA-912694:r:Regulation of IFNA/IFNB 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"PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I"], "type": "Family"}, "IPR016675": {"description": "Uncharacterised conserved protein UCP016666", "go_ids": [], "go_terms": [], "name": "UCP016666", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016676": {"description": "Phospholipid/glycerol acyltransferase, predicted", "go_ids": [], "go_terms": [], "name": "P_lipid/glycerol_AcTrfase_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016677": {"description": "Uncharacterised conserved protein UCP016817, ATP-dependent carboligase", "go_ids": [], "go_terms": [], "name": "UCP016817_carboligase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016678": {"description": "Mono-ADP-ribosyltransferase C3/Edin", "go_ids": ["GO:1990404", "GO:0016763"], "go_terms": ["GO:1990404:NAD+-protein mono-ADP-ribosyltransferase activity:F", "GO:0016763:pentosyltransferase activity:F"], "name": "Mono-ADP_RibTrfase_C3/Edin", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis"], "type": "Family"}, "IPR016679": {"description": "Transcription factor, GATA, plant", "go_ids": ["GO:0045893", "GO:0003677", "GO:0005634"], "go_terms": ["GO:0045893:positive regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F", "GO:0005634:nucleus:C"], "name": "TF_GATA_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016680": {"description": "NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8", "go_ids": ["GO:0006120"], "go_terms": ["GO:0006120:mitochondrial electron transport, NADH to ubiquinone:P"], "name": "NDUFA8", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR016681": {"description": "Succinylglutamate desuccinylase", "go_ids": ["GO:0008270", "GO:0009017", "GO:0006527"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0009017:succinylglutamate desuccinylase activity:F", "GO:0006527:L-arginine catabolic process:P"], "name": "SuccinylGlu_desuccinylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016682": {"description": "Flagella accessory protein D, predicted, archaeal", "go_ids": [], "go_terms": [], "name": "FlaD_prd_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016683": {"description": "Glycosyl transferase, family 28, RedA, predicted", "go_ids": [], "go_terms": [], "name": "Glyco_trans_28_RedA_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016684": {"description": "Type III secretion system chaperone, YscY", "go_ids": [], "go_terms": [], "name": "T3SS_YscY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016685": {"description": "RNA-induced silencing complex, nuclease component Tudor-SN", "go_ids": ["GO:0031332", "GO:0031047"], "go_terms": ["GO:0031332:RNAi effector complex:C", "GO:0031047:regulatory ncRNA-mediated gene silencing:P"], "name": "Silence_cplx_Nase-comp_TudorSN", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Family"}, "IPR016686": {"description": "Ribosome biogenesis factor, NIP7", "go_ids": ["GO:0005634", "GO:0042255"], "go_terms": ["GO:0005634:nucleus:C", "GO:0042255:ribosome assembly:P"], "name": "Ribosomal_synth_fac_NIP7", "pathway_ids": ["R-MMU-6791226", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR016688": {"description": "Mechanosensitive ion channel MscS-like, plants/fungi", "go_ids": [], "go_terms": [], "name": "MscS-like_plants/fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016689": {"description": "ESCRT-2 complex, Snf8", "go_ids": ["GO:0000814", "GO:0071985"], "go_terms": ["GO:0000814:ESCRT II complex:C", "GO:0071985:multivesicular body sorting pathway:P"], "name": "ESCRT-2_cplx_Snf8", "pathway_ids": ["R-RNO-917729", "R-HSA-917729", "R-HSA-9610379", "R-XTR-917729", "R-DRE-917729", "R-MMU-917729", "R-SPO-917729", "R-DDI-917729", "R-SCE-917729"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-XTR-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SPO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Family"}, "IPR016690": {"description": "TSEN34", "go_ids": ["GO:0000213", "GO:0000214", "GO:0000379"], "go_terms": ["GO:0000213:tRNA-intron lyase activity:F", "GO:0000214:tRNA-intron endonuclease complex:C", "GO:0000379:tRNA-type intron splice site recognition and cleavage:P"], "name": "TSEN34", "pathway_ids": ["PWY-7803", "PWY-6689", "R-HSA-6784531"], "pathways": ["PWY-7803:t:tRNA splicing II", "PWY-6689:t:tRNA splicing I", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR016692": {"description": "Sulfiredoxin", "go_ids": ["GO:0032542"], "go_terms": ["GO:0032542:sulfiredoxin activity:F"], "name": "Sulfiredoxin", "pathway_ids": ["R-SCE-9818027", "R-MMU-9818027", "R-SPO-9818027", "R-DME-9818027", "R-HSA-9818027"], "pathways": ["R-SCE-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-MMU-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-SPO-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-DME-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes"], "type": "Family"}, "IPR016694": {"description": "Protein of unknown function 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"R-BTA-9755088:r:Ribavirin ADME", "R-XTR-74259:r:Purine catabolism", "R-BTA-74259:r:Purine catabolism", "R-HSA-74259:r:Purine catabolism", "R-MMU-74259:r:Purine catabolism", "R-HSA-9755088:r:Ribavirin ADME", "R-XTR-2161541:r:Abacavir metabolism", "R-DDI-74259:r:Purine catabolism"], "type": "Family"}, "IPR016696": {"description": "TRAPP I complex, subunit 5", "go_ids": ["GO:0030008", "GO:0048193"], "go_terms": ["GO:0030008:TRAPP complex:C", "GO:0048193:Golgi vesicle transport:P"], "name": "TRAPP-I_su5", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-DDI-204005", "R-MMU-8876198", "R-DDI-8876198", "R-PFA-8876198", "R-PFA-204005", "R-SCE-204005", "R-SPO-204005", "R-HSA-8876198", "R-GGA-204005", "R-SPO-8876198", "R-SCE-8876198"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-PFA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-PFA-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-GGA-204005:r:COPII-mediated vesicle transport", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR016697": {"description": "Aquaporin 11/12", "go_ids": [], "go_terms": [], "name": "Aquaporin_11/12", "pathway_ids": ["R-MMU-432047", "R-HSA-432047", "R-RNO-432047", "R-CEL-432047"], "pathways": ["R-MMU-432047:r:Passive transport by Aquaporins", "R-HSA-432047:r:Passive transport by Aquaporins", "R-RNO-432047:r:Passive transport by Aquaporins", "R-CEL-432047:r:Passive transport by Aquaporins"], "type": "Family"}, "IPR016698": {"description": "Numb/numb-like", "go_ids": [], "go_terms": [], "name": "Numb/numb-like", "pathway_ids": ["R-HSA-5610780", "R-RNO-5632684", "R-MMU-5610780", "R-RNO-5610780", "R-MMU-437239", "R-MMU-5632684", "R-HSA-9725554", "R-RNO-437239", "R-HSA-2122948", "R-HSA-437239", "R-HSA-5632684"], "pathways": ["R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-5632684:r:Hedgehog 'on' state"], "type": "Family"}, "IPR016699": {"description": "Acid ceramidase-like", "go_ids": ["GO:0017064", "GO:0006631", "GO:0005764"], "go_terms": ["GO:0017064:fatty acid amide hydrolase activity:F", "GO:0006631:fatty acid metabolic process:P", "GO:0005764:lysosome:C"], "name": "Acid_ceramidase-like", "pathway_ids": ["PWY-6483", "PWY-7119", "R-HSA-6798695", "R-BTA-9840310", "R-RNO-9840310", "R-MMU-9840310", "R-CEL-112310", "R-CEL-9840310", "R-HSA-9840310", "R-CEL-6798695", "R-HSA-9857377", "R-MMU-6798695", "R-BTA-6798695", "R-HSA-112310", "R-RNO-112310", "R-MMU-112310", "R-RNO-6798695"], "pathways": ["PWY-6483:t:ceramide degradation (generic)", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-CEL-112310:r:Neurotransmitter release cycle", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-112310:r:Neurotransmitter release cycle", "R-RNO-112310:r:Neurotransmitter release cycle", "R-MMU-112310:r:Neurotransmitter release cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR016700": {"description": "3-hydroxyanthranilate 3, 4-dioxygenase, metazoan", "go_ids": ["GO:0000334", "GO:0005737", "GO:0046872"], "go_terms": ["GO:0000334:3-hydroxyanthranilate 3,4-dioxygenase activity:F", "GO:0005737:cytoplasm:C", "GO:0046872:metal ion binding:F"], "name": "3hydroanth_dOase_met", "pathway_ids": ["PWY-6505", "PWY-6309", "PWY-5647", "PWY-5651", "R-HSA-71240", "R-RNO-71240", "R-CEL-71240", "R-DRE-71240", "R-MMU-71240"], "pathways": ["PWY-6505:t:L-tryptophan degradation XII (Geobacillus)", "PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-5647:t:2-nitrobenzoate degradation I", "PWY-5651:t:L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde", "R-HSA-71240:r:Tryptophan catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-CEL-71240:r:Tryptophan catabolism", "R-DRE-71240:r:Tryptophan catabolism", "R-MMU-71240:r:Tryptophan catabolism"], "type": "Family"}, "IPR016702": {"description": "ATP synthase, F0 complex, gamma subunit, metazoa", "go_ids": [], "go_terms": [], "name": "ATP5MG_metazoa", "pathway_ids": ["R-MMU-9837999", "R-MMU-163210", "R-HSA-9837999", "R-RNO-163210", "R-RNO-8949613", "R-RNO-9837999", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR016703": {"description": "Conjugal transfer, TraD, beta/gamma-type", "go_ids": [], "go_terms": [], "name": "Conjugal_tfr_TraD_b/g-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016704": {"description": "Conjugal transfer, TrbD", "go_ids": [], "go_terms": [], "name": "Conjugal_tfr_TrbD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016705": {"description": "Photosynthesis system II assembly factor Ycf48/Hcf136", "go_ids": [], "go_terms": [], "name": "Ycf48/Hcf136", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016706": {"description": "Cleavage/polyadenylation specificity factor subunit 5", "go_ids": ["GO:0031124", "GO:0005849", "GO:0003729"], "go_terms": ["GO:0031124:mRNA 3'-end processing:P", "GO:0005849:mRNA cleavage factor complex:C", "GO:0003729:mRNA binding:F"], "name": "Cleav_polyA_spec_factor_su5", "pathway_ids": ["R-HSA-9770562", "R-DRE-77595", "R-MMU-9770562", "R-MMU-77595", "R-HSA-73856", "R-BTA-73856", "R-RNO-77595", "R-DDI-9770562", "R-HSA-72187", "R-MMU-73856", "R-RNO-73856", "R-HSA-77595", "R-DRE-73856", "R-MMU-72187", "R-DRE-9770562", "R-RNO-9770562", "R-BTA-9770562", "R-HSA-9918481", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-DRE-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Family"}, "IPR016707": {"description": "Conjugal transfer, TraB, rhizobiales", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Conjugal_tfr_TraB_rhizob", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016708": {"description": "Aspartoacylase", "go_ids": ["GO:0016811"], "go_terms": ["GO:0016811:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides:F"], "name": "Aspartoacylase", "pathway_ids": ["R-MMU-5423646", "R-XTR-8963693", "R-RNO-5423646", "R-MMU-8963693", "R-HSA-8963693", "R-XTR-5423646", "R-HSA-5423646", "R-RNO-8963693", "R-DRE-5423646", "R-DRE-8963693"], "pathways": ["R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-XTR-8963693:r:Aspartate and asparagine metabolism", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-XTR-5423646:r:Aflatoxin activation and detoxification", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-DRE-5423646:r:Aflatoxin activation and detoxification", "R-DRE-8963693:r:Aspartate and asparagine metabolism"], "type": "Family"}, "IPR016709": {"description": "Dehydratase subunit HadA-like", "go_ids": [], "go_terms": [], "name": "HadA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016710": {"description": "Emp46/Emp47", "go_ids": ["GO:0006888", "GO:0016020"], "go_terms": ["GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P", "GO:0016020:membrane:C"], "name": "Emp46/Emp47", "pathway_ids": ["R-SCE-9013106"], "pathways": ["R-SCE-9013106:r:RHOC GTPase cycle"], "type": "Family"}, "IPR016711": {"description": "Sds23", "go_ids": ["GO:0042149", "GO:0030071"], "go_terms": ["GO:0042149:cellular response to glucose starvation:P", "GO:0030071:regulation of mitotic metaphase/anaphase transition:P"], "name": "Ssd23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016712": {"description": "Small ribosomal subunit protein bS1m-like", "go_ids": [], "go_terms": [], "name": "Rbsml_bS1m-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016713": {"description": "Poly(A) polymerase complex subunit Air1/2, budding yeast", "go_ids": ["GO:0043633"], "go_terms": ["GO:0043633:polyadenylation-dependent RNA catabolic process:P"], "name": "Air1/2_Saccharomycetales", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016714": {"description": "Mannan endo-1,4-beta-mannosidase B/E", "go_ids": ["GO:0006080", "GO:0016985"], "go_terms": ["GO:0006080:substituted mannan metabolic process:P", "GO:0016985:mannan endo-1,4-beta-mannosidase activity:F"], "name": "MANB/E", "pathway_ids": ["PWY-7456"], "pathways": ["PWY-7456:t:beta-(1,4)-mannan degradation"], "type": "Family"}, "IPR016715": {"description": "Platelet-activating factor acetylhydrolase-like, eukaryote", "go_ids": ["GO:0003847"], "go_terms": ["GO:0003847:1-alkyl-2-acetylglycerophosphocholine esterase activity:F"], "name": "PAF_acetylhydro_eukaryote", "pathway_ids": ["R-MMU-422085", "R-BTA-418346", "R-HSA-418346", "R-SPO-418346", "R-HSA-422085", "R-MMU-418346", "R-CEL-418346", "R-RNO-418346"], "pathways": ["R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-418346:r:Platelet homeostasis", "R-HSA-418346:r:Platelet homeostasis", "R-SPO-418346:r:Platelet homeostasis", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-418346:r:Platelet homeostasis", "R-CEL-418346:r:Platelet homeostasis", "R-RNO-418346:r:Platelet homeostasis"], "type": "Family"}, "IPR016716": {"description": "Regulator of ribonuclease activity B", "go_ids": [], "go_terms": [], "name": "RraB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016717": {"description": "Gip2/Pig2", "go_ids": [], "go_terms": [], "name": "Gip2/Pig2", "pathway_ids": ["R-SCE-3322077"], "pathways": ["R-SCE-3322077:r:Glycogen synthesis"], "type": "Family"}, "IPR016718": {"description": "rRNA (guanine-N1-)-methyltransferase A, predicted", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "rRNA_m1G-MeTrfase_A_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016719": {"description": "Guided entry of tail-anchored proteins factor CAMLG", "go_ids": [], "go_terms": [], "name": "CAMLG", "pathway_ids": ["R-HSA-9609523"], "pathways": ["R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Family"}, "IPR016720": {"description": "Phosphatidate cytidylyltransferase, eukaryota", "go_ids": ["GO:0004605"], "go_terms": ["GO:0004605:phosphatidate cytidylyltransferase activity:F"], "name": "PC_Trfase_euk", "pathway_ids": ["PWY-5981", "PWY-7817", "PWY-5667", "R-CEL-1483148", "R-DDI-1483148", "R-HSA-1483226", "R-SPO-1483148", "R-DME-1483148", "R-SCE-1483226", "R-HSA-1483148", "R-SCE-1483148", "R-CEL-1483226", "R-DDI-1483226", "R-SPO-1483226", "R-MMU-1483226", "R-RNO-1483148", "R-RNO-1483226", "R-DME-1483226", "R-MMU-1483148", "R-BTA-1483148"], "pathways": ["PWY-5981:t:CDP-diacylglycerol biosynthesis III", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-5667:t:CDP-diacylglycerol biosynthesis I", "R-CEL-1483148:r:Synthesis of PG", "R-DDI-1483148:r:Synthesis of PG", "R-HSA-1483226:r:Synthesis of PI", "R-SPO-1483148:r:Synthesis of PG", "R-DME-1483148:r:Synthesis of PG", "R-SCE-1483226:r:Synthesis of PI", "R-HSA-1483148:r:Synthesis of PG", "R-SCE-1483148:r:Synthesis of PG", "R-CEL-1483226:r:Synthesis of PI", "R-DDI-1483226:r:Synthesis of PI", "R-SPO-1483226:r:Synthesis of PI", "R-MMU-1483226:r:Synthesis of PI", "R-RNO-1483148:r:Synthesis of PG", "R-RNO-1483226:r:Synthesis of PI", "R-DME-1483226:r:Synthesis of PI", "R-MMU-1483148:r:Synthesis of PG", "R-BTA-1483148:r:Synthesis of PG"], "type": "Family"}, "IPR016721": {"description": "Bet3 family", "go_ids": ["GO:0048193", "GO:0030008"], "go_terms": ["GO:0048193:Golgi vesicle transport:P", "GO:0030008:TRAPP complex:C"], "name": "Bet3", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-DDI-204005", "R-MMU-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-CEL-204005", "R-SCE-204005", "R-RNO-8876198", "R-SPO-204005", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198", "R-RNO-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-204005:r:COPII-mediated vesicle transport"], "type": "Family"}, "IPR016722": {"description": "DNA polymerase alpha, subunit B", "go_ids": [], "go_terms": [], "name": "DNA_pol_alpha_bsu", "pathway_ids": ["R-MMU-174430", "R-RNO-68962", "R-CEL-69091", "R-CEL-68962", "R-SCE-69091", "R-CEL-113501", "R-CEL-69166", "R-DME-113501", "R-RNO-69183", "R-DDI-68952", "R-RNO-69166", "R-DME-68962", "R-DDI-68962", "R-CEL-69183", "R-SPO-69091", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-RNO-68952", "R-RNO-174411", "R-SCE-68952", "R-SPO-69166", "R-HSA-113501", "R-SCE-69183", "R-HSA-68952", "R-DDI-113501", "R-DDI-69091", "R-MMU-68962", "R-DDI-69183", "R-RNO-174430", "R-SPO-69183", "R-HSA-174430", "R-MMU-113501", "R-DME-69091", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-SCE-68962", "R-SCE-113501", "R-DDI-69166", "R-RNO-69091", "R-HSA-9710421", "R-MMU-68952", "R-RNO-113501", "R-SPO-113501", "R-SPO-68952", "R-CEL-68952", "R-MMU-69166", "R-SCE-69166", "R-HSA-69183", "R-SPO-68962", "R-HSA-69091", "R-MMU-174411", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-CEL-69091:r:Polymerase switching", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-SCE-69091:r:Polymerase switching", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-DDI-68952:r:DNA replication initiation", "R-RNO-69166:r:Removal of the 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"Family"}, "IPR016743": {"description": "Nuclear factor interleukin-3-regulated protein", "go_ids": ["GO:0006366", "GO:0005634", "GO:0003700", "GO:0006955"], "go_terms": ["GO:0006366:transcription by RNA polymerase II:P", "GO:0005634:nucleus:C", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0006955:immune response:P"], "name": "NFIL3/E4BP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016744": {"description": "Uncharacterised conserved protein UCP019072", "go_ids": [], "go_terms": [], "name": "UCP019072", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016745": {"description": "Archaeal GINS complex, Gins51 subunit", "go_ids": [], "go_terms": [], "name": "Gins51", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016746": {"description": "Uncharacterised conserved protein UCP019078", "go_ids": [], "go_terms": [], "name": "UCP019078", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016747": {"description": "Phosphotransbutyrylase", "go_ids": [], "go_terms": [], "name": "Phosphotransbutyrylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016748": {"description": "Transcription regulator, CopG/Arc/MetJ DNA-binding domain-containing, predicted", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_CopG_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016750": {"description": "Acetophenone carboxylase beta subunit/Acetone carboxylase gamma subunit", "go_ids": [], "go_terms": [], "name": "Aceto_COase_bsu/gsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016751": {"description": "Uncharacterised conserved protein UCP019236", "go_ids": [], "go_terms": [], "name": "UCP019236", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016752": {"description": "Uncharacterised conserved protein UCP019240, SpoVT/AbrB-related", "go_ids": [], "go_terms": [], "name": "UCP019240_SpoVT/AbrB-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016753": {"description": "Phage portal protein PBSX family, Firmicutes", "go_ids": [], "go_terms": [], "name": "PBSX_Firmicutes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016754": {"description": "Connectase MJ0548-like", "go_ids": [], "go_terms": [], "name": "MJ0548-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016755": {"description": "Uncharacterised conserved protein UCP019302", "go_ids": [], "go_terms": [], "name": "UCP019302", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016756": {"description": "Metal-dependent hydrolase, membrane-bound predicted", "go_ids": [], "go_terms": [], "name": "Metal-dep_Ohase_Mem-prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016757": {"description": "Uncharacterised conserved protein UCP019322", "go_ids": [], "go_terms": [], "name": "UCP019322", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016758": {"description": "Glucose-6-phosphate isomerase, archaea/bacteria", 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degradation II (sucrose synthase)", "PWY-5054:t:D-sorbitol biosynthesis I"], "type": "Family"}, "IPR016759": {"description": "HTH-type transcriptional repressor RghR", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RghR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016760": {"description": "Iron-guanylylpyridinol cofactor synthase", "go_ids": [], "go_terms": [], "name": "HcgG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016761": {"description": "Uncharacterised conserved protein UCP019454, CBS", "go_ids": [], "go_terms": [], "name": "UCP019454_CBS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016762": {"description": "Methanogenesis marker 17 protein", "go_ids": [], "go_terms": [], "name": "Methan_mark_17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016763": {"description": "Vesicle-associated membrane-protein-associated protein", "go_ids": ["GO:0005789"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C"], "name": "VAP", "pathway_ids": ["R-HSA-9013405", "R-HSA-6798695", "R-SPO-6798695", "R-SSC-9013404", "R-MMU-9013106", "R-SSC-9013408", "R-MMU-8980692", "R-RNO-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-BTA-6798695", "R-SSC-8980692", "R-HSA-9013106", "R-HSA-1660661", "R-MMU-9013404", "R-RNO-9609523", "R-SCE-9013106", "R-BTA-9609523", "R-HSA-9013404", "R-BTA-9013408", "R-BTA-1660661", "R-HSA-8980692", "R-SPO-9609523", "R-BTA-9013404", "R-BTA-8980692", "R-MMU-6798695", "R-SSC-9013106", "R-HSA-9013408", "R-SCE-9609523", "R-HSA-9609523", "R-RNO-9013408", "R-MMU-9609523", "R-RNO-9013106", "R-RNO-9013404", "R-BTA-9013106", "R-RNO-6798695"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-SSC-9013408:r:RHOG GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9013106:r:RHOC GTPase cycle", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9013408:r:RHOG GTPase cycle", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR016764": {"description": "Methyltransferase Mtx subunit X", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "MeTrfase_MtxX_xsu", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR016765": {"description": "Metal-dependent membrane protease, predicted", "go_ids": [], "go_terms": [], "name": "M_metal-dep_Prtase_arc_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016766": {"description": "Trichothecene biosynthesis transcription regulator TRI6", "go_ids": ["GO:0006355", "GO:0003676"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003676:nucleic acid binding:F"], "name": "Tscrpt_reg_Tri6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016767": {"description": "Uncharacterised conserved protein UCP019853", "go_ids": [], "go_terms": [], "name": "UCP019853", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016768": {"description": "Uncharacterised conserved protein UCP019883, membrane", "go_ids": [], "go_terms": [], "name": "UCP019883", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016769": {"description": "Bacteriophage SP01, Orf1", "go_ids": [], "go_terms": [], "name": "Phage_SP01_Orf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016770": {"description": "Nonstructural, NS2", "go_ids": [], "go_terms": [], "name": "Non-structural_NS2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016771": {"description": "Fe-S oxidoreductase, radical SAM domain-containing, TM0948, predicted", "go_ids": [], "go_terms": [], "name": "Fe-S_OxRdtase_rSAM_TM0948_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016772": {"description": "Uncharacterised conserved protein UCP020408", "go_ids": [], "go_terms": [], "name": "UCP020408", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016773": {"description": "Ferric uptake regulator, CjrA, predicted", "go_ids": [], "go_terms": [], "name": "Fe3_uptake_reg_CjrA_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016775": {"description": "Nodulation, NolB", "go_ids": [], "go_terms": [], "name": "Nodulation_NolB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016776": {"description": "ApeP-like dehydratase", "go_ids": [], "go_terms": [], "name": "ApeP-like_dehydratase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016777": {"description": "Uncharacterised conserved protein UCP020772", "go_ids": [], "go_terms": [], "name": "UCP020772", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016778": {"description": "Competence protein ComB", "go_ids": [], "go_terms": [], "name": "Competence_ComB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016779": {"description": "Radical SAM enzyme, MSMEG0568", "go_ids": [], "go_terms": [], "name": "rSAM_MSMEG0568", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016780": {"description": "Uncharacterised conserved protein UCP020893, cyanophyceae", "go_ids": [], "go_terms": [], "name": "UCP020893_cyanophy", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016781": {"description": "Anti-sigma regulatory factor, PmgA, predicted", "go_ids": [], "go_terms": [], "name": "Anti-sigma_regulat_PmgA_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016782": {"description": "Uncharacterised conserved protein UCP022271", "go_ids": [], "go_terms": [], "name": "UCP022271", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016783": {"description": "Biofilm formation YmcA", "go_ids": [], "go_terms": [], "name": "Biofilm_formation_YmcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016784": {"description": "Uncharacterised protein UCP021288 with ACT domain", "go_ids": [], "go_terms": [], "name": "UCP021288_ACT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016785": {"description": "Competence protein ComGD", "go_ids": ["GO:0030420"], "go_terms": ["GO:0030420:establishment of competence for transformation:P"], "name": "ComGD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016786": {"description": "Uncharacterised protein YdeI, bacterial", "go_ids": [], "go_terms": [], "name": "YdeI_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016787": {"description": "Uncharacterised conserved protein UCP021328", "go_ids": [], "go_terms": [], "name": "UCP021328", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016788": {"description": "Membrane protein YqfB, bacillales", "go_ids": [], "go_terms": [], "name": "YqfB_bacillales", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016789": {"description": "Uncharacterised conserved protein UCP021389", "go_ids": [], "go_terms": [], "name": "UCP021389", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016790": {"description": "Thiol ester hydratase, Rv0216, predicted", "go_ids": [], "go_terms": [], "name": "Thiol_ester_hydratase_Rv0216", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016791": {"description": "Rubromycin-type polyketide biosynthesis protein, GrhN/RubW, predicted", "go_ids": [], "go_terms": [], "name": "Polyketide_synth_GrhN/RubW_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016792": {"description": "Uncharacterised conserved protein UCP021573", "go_ids": [], "go_terms": [], "name": "UCP021573", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016793": {"description": "Uncharacterised conserved protein UCP021591", "go_ids": [], "go_terms": [], "name": "UCP021591", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016794": {"description": "Uncharacterised conserved protein UCP21603, acetyltransferase-like", "go_ids": [], "go_terms": [], "name": "UCP21603_acetyltransf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016795": {"description": "Uncharacterised conserved protein UCP021697, membrane", "go_ids": [], "go_terms": [], "name": "UCP021697", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016796": {"description": "Uncharacterised conserved protein UCP021774", "go_ids": [], "go_terms": [], "name": "UCP021774", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016797": {"description": "Uncharacterised conserved protein UCP021898", "go_ids": [], "go_terms": [], "name": "UCP021898", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016798": {"description": "Uncharacterised conserved protein UCP021980, OB-fold", "go_ids": [], "go_terms": [], "name": "UCP021980_OB-fold", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016799": {"description": "Uncharacterised conserved protein UCP022062", "go_ids": [], "go_terms": [], "name": "UCP022062", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016800": {"description": "Uncharacterised conserved protein UCP022080", "go_ids": [], "go_terms": [], "name": "UCP022080", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016801": {"description": "Uncharacterised conserved protein UCP022207", "go_ids": [], "go_terms": [], "name": "UCP022207", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016802": {"description": "Uncharacterised conserved protein UCP022260, magnoliopsida", "go_ids": [], "go_terms": [], "name": "UCP022260_magno", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016803": {"description": "RGS1-HXK1-interacting protein 1", "go_ids": ["GO:1902659"], "go_terms": ["GO:1902659:regulation of glucose mediated signaling pathway:P"], "name": "RHIP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016804": {"description": "Uncharacterised protein family UPF0114, plant", "go_ids": [], "go_terms": [], "name": "UPF0114_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016805": {"description": "Intermembrane space protein MIX23, fungal", "go_ids": ["GO:0005758"], "go_terms": ["GO:0005758:mitochondrial intermembrane space:C"], "name": "MIX23_fungal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016806": {"description": "COP9 signalosome complex, subunit 9, fungi", "go_ids": ["GO:0000338", "GO:0008180"], "go_terms": ["GO:0000338:protein deneddylation:P", "GO:0008180:COP9 signalosome:C"], "name": "Csn9_fungi", "pathway_ids": ["R-SCE-156827", "R-SCE-72649", "R-SCE-72702", "R-SCE-72695"], "pathways": ["R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72649:r:Translation initiation complex formation", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex"], "type": "Family"}, "IPR016807": {"description": "Anaphase-promoting complex subunit Mnd2", "go_ids": ["GO:0005680", "GO:0030071", "GO:0031145"], "go_terms": ["GO:0005680:anaphase-promoting complex:C", "GO:0030071:regulation of mitotic metaphase/anaphase transition:P", "GO:0031145:anaphase-promoting complex-dependent catabolic process:P"], "name": "Mnd2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016808": {"description": "Mitochondrial morphogenesis protein Sld7", "go_ids": ["GO:0030174"], "go_terms": ["GO:0030174:regulation of DNA-templated DNA replication initiation:P"], "name": "Sld7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016810": {"description": "DNA repair protein Rad59", "go_ids": ["GO:0045002"], "go_terms": ["GO:0045002:double-strand break repair via single-strand annealing:P"], "name": "Rad59", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016811": {"description": "Origin recognition complex, subunit 6, fungi", "go_ids": [], "go_terms": [], "name": "ORC6_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016812": {"description": "Protein phosphatase methylesterase, eukaryotic", "go_ids": ["GO:0051723", "GO:0006482"], "go_terms": ["GO:0051723:protein methylesterase activity:F", "GO:0006482:protein demethylation:P"], "name": "PPase_methylesterase_euk", "pathway_ids": ["R-CEL-69273", "R-HSA-69273", "R-RNO-69273", "R-SPO-69273", "R-BTA-69273", "R-MMU-69273", "R-SCE-69273", "R-DDI-69273"], "pathways": ["R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition"], "type": "Family"}, "IPR016813": {"description": "NADH-ubiquinone oxidoreductase 21.3 kDa subunit", "go_ids": [], "go_terms": [], "name": "NADH_Ub_cplx-1_21kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016814": {"description": "Profilin, apicomplexa", "go_ids": ["GO:0030036", "GO:0003779"], "go_terms": ["GO:0030036:actin cytoskeleton organization:P", "GO:0003779:actin binding:F"], "name": "Profilin_apicomplexa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016815": {"description": "Rhoptry 4/5", "go_ids": [], "go_terms": [], "name": "ROP4/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016816": {"description": "Surface antigen p22", "go_ids": [], "go_terms": [], "name": "SAG2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016817": {"description": "Mannose-P-dolichol utilization defect 1 protein", "go_ids": [], "go_terms": [], "name": "MannP-dilichol_defect-1", "pathway_ids": ["R-MMU-446193", "R-CEL-446193", "R-DME-446193", "R-HSA-4687000", "R-HSA-446193"], "pathways": ["R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-CEL-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DME-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-4687000:r:Defective MPDU1 causes CDG-1f", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Family"}, "IPR016818": {"description": "Nitric oxide synthase-interacting protein", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "NOSIP", "pathway_ids": ["PWY-7511", "R-BTA-203754", "R-HSA-203754", "R-MMU-203754", "R-DDI-203754", "R-DME-203754"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-DDI-203754:r:NOSIP mediated eNOS trafficking", "R-DME-203754:r:NOSIP mediated eNOS trafficking"], "type": "Family"}, "IPR016819": {"description": "Ribonuclease P/MRP protein subunit Pop5", "go_ids": ["GO:0033204", "GO:0001682"], "go_terms": ["GO:0033204:ribonuclease P RNA binding:F", "GO:0001682:tRNA 5'-leader removal:P"], "name": "RNase_P/MRP_POP5", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR016820": {"description": "Mediator complex, subunit Med6, metazoa/plant", "go_ids": ["GO:0003712", "GO:0006357", "GO:0016592"], "go_terms": ["GO:0003712:transcription coregulator activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C"], "name": "Mediator_Med6_met/pln", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-BTA-9841922", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR016821": {"description": "G0/G1 switch protein 2", "go_ids": [], "go_terms": [], "name": "G0S2", "pathway_ids": ["R-HSA-1989781"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression"], "type": "Family"}, "IPR016823": {"description": "Sulfur oxidation c-type cytochrome SoxX, type II", "go_ids": [], "go_terms": [], "name": "Thiosulf_SoxX_II", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016824": {"description": "Tfp pilus assembly protein FimT", "go_ids": [], "go_terms": [], "name": "Tfp-pilus_assembly_FimT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016825": {"description": "Flagella-related protein F", "go_ids": [], "go_terms": [], "name": "Flagellin-rel_FlaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016827": {"description": "Transcriptional adaptor 2", "go_ids": ["GO:0003713", "GO:0006357"], "go_terms": ["GO:0003713:transcription coactivator activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "Ada2/TADA2", "pathway_ids": ["R-BTA-9772755", "R-DRE-5689880", "R-HSA-3214847", "R-MMU-9772755", "R-DME-5689880", "R-HSA-9772755", "R-RNO-9772755", "R-HSA-5689880"], "pathways": ["R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR016828": {"description": "Alpha-L-arabinofuranosidase", "go_ids": [], "go_terms": [], "name": "Alpha-L-arabinofuranosidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016829": {"description": "Spodoptera frugiperda nuclear polyhedrosis virus (SfNPV), sf27", "go_ids": [], "go_terms": [], "name": "SfNPV_sf27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016830": {"description": "Ubiquinone biosynthesis accessory factor UbiT", "go_ids": ["GO:0006744"], "go_terms": ["GO:0006744:ubiquinone biosynthetic process:P"], "name": "UbiT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016831": {"description": "PPi-dependent kinase", "go_ids": [], "go_terms": [], "name": "PPi-dep_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016832": {"description": "Uncharacterised conserved protein UCP025926, globin-related", "go_ids": [], "go_terms": [], "name": "UCP025926_globin-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016833": {"description": "Putative sodium bile acid cotransporter", "go_ids": [], "go_terms": [], "name": "Put_Na-Bile_cotransptr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016834": {"description": "Uncharacterised conserved protein UCP026306", "go_ids": [], "go_terms": [], "name": "UCP026306", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016835": {"description": "Uncharacterised conserved protein UCP026317, WGR", "go_ids": [], "go_terms": [], "name": "UCP026317_WGR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016836": {"description": "Long-chain acyl-[acyl-carrier-protein] reductase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "AAR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016837": {"description": "Uncharacterised protein family Ycf55, cyanobacteria", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf55_cyanobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016838": {"description": "Uncharacterised conserved protein UCP026449", "go_ids": [], "go_terms": [], "name": "UCP026449", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016839": {"description": "Signal transduction diguanylate cyclase, CHASE2 sensor domain-containing, predicted", "go_ids": [], "go_terms": [], "name": "Sig_transdc_diG_cyclase_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016840": {"description": "Glycoside hydrolase, family 43, endo-1, 5-alpha-L-arabinosidase", "go_ids": ["GO:0046558"], "go_terms": ["GO:0046558:arabinan endo-1,5-alpha-L-arabinosidase activity:F"], "name": "Glyco_hydro_43_endo_a_Ara-ase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016841": {"description": "Transcription regulator DksA-related, predicted", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_DksA-rel_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016842": {"description": "Protein of unknown function UCP026546, HtH-CBS", "go_ids": [], "go_terms": [], "name": "UCP026546_HTH-CBS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016843": {"description": "S-adenosyl-L-methionine dependent adenine methyltransferase, bacteria, predicted", "go_ids": [], "go_terms": [], "name": "S-AdoMet-dep_Ade-MeTrfase_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016844": {"description": "Uncharacterised conserved protein UCP026610", "go_ids": [], "go_terms": [], "name": "UCP026610", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016845": {"description": "Uncharacterised conserved protein UCP026633, TfuA-like, mycobacteria", "go_ids": [], "go_terms": [], "name": "UCP026633_TfuA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016846": {"description": "Predicted ion channel, cNMP-binding", "go_ids": [], "go_terms": [], "name": "cNMP-bd_ion_channel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016847": {"description": "Mannose-6-phosphate isomerase, Firmicutes, long form, predicted", "go_ids": [], "go_terms": [], "name": "Man6P_Isoase_Firm_lng_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016848": {"description": "Ribonuclease P/MRP subunit Rpp29", "go_ids": ["GO:0000172", "GO:0030677", "GO:0001682", "GO:0006396", "GO:0033204"], "go_terms": ["GO:0000172:ribonuclease MRP complex:C", "GO:0030677:ribonuclease P complex:C", "GO:0001682:tRNA 5'-leader removal:P", "GO:0006396:RNA processing:P", "GO:0033204:ribonuclease P RNA binding:F"], "name": "RNase_P/MRP_Rpp29-subunit", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR016849": {"description": "Histone acetyltransferase Rtt109", "go_ids": ["GO:0010484", "GO:0005634", "GO:0006325"], "go_terms": ["GO:0010484:histone H3 acetyltransferase activity:F", "GO:0005634:nucleus:C", "GO:0006325:chromatin organization:P"], "name": "Rtt109", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016850": {"description": "Transcription initiation factor Rrn11, budding yeast", "go_ids": [], "go_terms": [], "name": "TIF_Rrn11_budding_yeast", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016851": {"description": "Kinetochore-associated protein Nnf1", "go_ids": ["GO:0000444"], "go_terms": ["GO:0000444:MIS12/MIND type complex:C"], "name": "Nnf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016852": {"description": "SET domain methyltransferase", "go_ids": [], "go_terms": [], "name": "SET_MeTrfase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR016853": {"description": "S-adenosyl-L-methionine binding protein, YMR209C, predicted", "go_ids": [], "go_terms": [], "name": "S-AdoMet-bd_YMR209C_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016854": {"description": "Cell death protein 4", "go_ids": [], "go_terms": [], "name": "Ced-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016855": {"description": "Endoplasmic reticulum resident protein 29", "go_ids": ["GO:0005783"], "go_terms": ["GO:0005783:endoplasmic reticulum:C"], "name": "ERp29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016856": {"description": "NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 1", "go_ids": ["GO:0005737", "GO:0008616", "GO:0046857"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008616:tRNA queuosine(34) biosynthetic process:P", "GO:0046857:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor:F"], "name": "QueF_type1", "pathway_ids": ["PWY-6700"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)"], "type": "Family"}, "IPR016857": {"description": "Uncharacterised conserved protein UCP027682, CUB, vWA", "go_ids": [], "go_terms": [], "name": "UCP027682_CUB_vWA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016859": {"description": "Uncharacterised conserved protein UCP207779", "go_ids": [], "go_terms": [], "name": "UCP207779", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016860": {"description": "Cerberus", "go_ids": [], "go_terms": [], "name": "Cerberus", "pathway_ids": ["R-MMU-201451", "R-HSA-9937080", "R-HSA-201451", "R-HSA-1181150", "R-XTR-201451", "R-HSA-1433617", "R-GGA-201451"], "pathways": ["R-MMU-201451:r:Signaling by BMP", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-201451:r:Signaling by BMP", "R-HSA-1181150:r:Signaling by NODAL", "R-XTR-201451:r:Signaling by BMP", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-GGA-201451:r:Signaling by BMP"], "type": "Family"}, "IPR016862": {"description": "Uncharacterised conserved protein UCP027936", "go_ids": [], "go_terms": [], "name": "UCP027936", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016863": {"description": "dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase", "go_ids": ["GO:0033068", "GO:0016841", "GO:0051539"], "go_terms": ["GO:0033068:macrolide biosynthetic process:P", "GO:0016841:ammonia-lyase activity:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "DesII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016864": {"description": "Uncharacterised conserved protein UCP028035", "go_ids": [], "go_terms": [], "name": "UCP028035", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016865": {"description": "Inner membrane protein RclC", "go_ids": [], "go_terms": [], "name": "RclC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016866": {"description": "Uncharacterised conserved protein UCP028069", "go_ids": [], "go_terms": [], "name": "UCP028069", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016867": {"description": "Glycine cleavage system transcriptional repressor", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "GcvR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016868": {"description": "UCP028111", "go_ids": [], "go_terms": [], "name": "UCP028111", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016869": {"description": "Uncharacterised conserved protein UCP028135, HipA-like", "go_ids": [], "go_terms": [], "name": "UCP028135_HipA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016870": {"description": "Uncharacterised conserved protein UCP028137, membrane", "go_ids": [], "go_terms": [], "name": "UCP028137", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016871": {"description": "MSHA biogenesis protein, MshI", "go_ids": [], "go_terms": [], "name": "MSHA_biogenesis_MshI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016872": {"description": "Uncharacterised conserved protein UCP028160", "go_ids": [], "go_terms": [], "name": "UCP028160", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016873": {"description": "Capsular polysaccharide biosynthesis protein, BcbE, predicted", "go_ids": [], "go_terms": [], "name": "Caps_polysacc_synth_BcbE_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016874": {"description": "Methyltransferase TcmP-like", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "TcmP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016875": {"description": "Uncharacterised conserved protein UCP028200", "go_ids": [], "go_terms": [], "name": "UCP028200", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016876": {"description": "Uncharacterised conserved protein UCP028234", "go_ids": [], "go_terms": [], "name": "UCP028234", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016877": {"description": "Uncharacterised conserved protein UCP028235", "go_ids": [], "go_terms": [], "name": "UCP028235", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016878": {"description": "Metal-independent carbonic anhydrase-like", "go_ids": [], "go_terms": [], "name": "MICAH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016879": {"description": "Uncharacterised conserved protein UCP028299", "go_ids": [], "go_terms": [], "name": "UCP028299", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016880": {"description": "ABC-type oligopeptide transport system, solute-binding component, Mycoplasmataceae, predicted", "go_ids": [], "go_terms": [], "name": "ABC_oligopep_solut-bd_myco_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016881": {"description": "Uncharacterised conserved protein UCP028340", "go_ids": [], "go_terms": [], "name": "UCP028340", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016882": {"description": "Nucleoside triphosphate/diphosphate phosphatase", "go_ids": [], "go_terms": [], "name": "SA1684", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Family"}, "IPR016883": {"description": "Uncharacterised conserved protein UCP028431", "go_ids": [], "go_terms": [], "name": "UCP028431", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016884": {"description": "Uncharacterised conserved protein UCP028438", "go_ids": [], "go_terms": [], "name": "UCP028438", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016885": {"description": "Uncharacterised conserved protein UCP028445", "go_ids": [], "go_terms": [], "name": "UCP028445", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016886": {"description": "Predicted glycerophosphotransferase UCP028458", "go_ids": [], "go_terms": [], "name": "UCP028458_glyceroPtfrase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016887": {"description": "Uncharacterised conserved protein UCP028470, steroid isomerase-related", "go_ids": [], "go_terms": [], "name": "UCP028470_steroid_isom-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016888": {"description": "Uncharacterised conserved protein UCP028498", "go_ids": [], "go_terms": [], "name": "UCP028498", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016889": {"description": "Uncharacterised conserved protein UCP028503", "go_ids": [], "go_terms": [], "name": "UCP028503", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016890": {"description": "Uncharacterised conserved protein UCP028520", "go_ids": [], "go_terms": [], "name": "UCP028520", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016891": {"description": "Protein of unknown function DUF2321", "go_ids": [], "go_terms": [], "name": "DUF2321", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016892": {"description": "Uncharacterised conserved protein UCP028583", "go_ids": [], "go_terms": [], "name": "UCP028583", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016893": {"description": "Protein of unknown function UCP028589", "go_ids": [], "go_terms": [], "name": "UCP028589", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016895": {"description": "Uncharacterised conserved protein UCP028680", "go_ids": [], "go_terms": [], "name": "UCP028680", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016896": {"description": "Protein of unknown function DUF2860", "go_ids": [], "go_terms": [], "name": "DUF2860", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016897": {"description": "S-phase kinase-associated protein 1", "go_ids": ["GO:0006511"], "go_terms": ["GO:0006511:ubiquitin-dependent protein catabolic process:P"], "name": "SKP1", "pathway_ids": ["R-DDI-8854050", "R-BTA-174113", "R-BTA-983168", "R-HSA-9020702", "R-BTA-69231", "R-RNO-68949", "R-RNO-9020702", "R-HSA-9604323", "R-MMU-5607764", "R-BTA-5610785", "R-BTA-1170546", "R-HSA-8951664", "R-HSA-9932298", "R-CEL-195253", "R-MMU-9020702", "R-CEL-187577", "R-HSA-5676590", "R-HSA-69231", "R-MMU-2565942", "R-DDI-8951664", "R-MMU-8951664", "R-HSA-5684264", "R-BTA-69601", "R-RNO-202424", "R-HSA-174113", "R-HSA-8854050", "R-BTA-9762114", "R-RNO-8854050", "R-MMU-9929356", "R-RNO-5607761", "R-CEL-69231", "R-HSA-5610783", "R-HSA-2122947", "R-RNO-9929356", "R-HSA-9708530", "R-MMU-5684264", "R-CEL-917937", "R-HSA-5607761", "R-HSA-1170546", "R-MMU-174113", "R-RNO-917937", "R-BTA-9708530", "R-MMU-9708530", "R-HSA-1169091", "R-HSA-2644607", "R-MMU-2871837", "R-BTA-917937", "R-RNO-8951664", "R-DDI-68949", "R-HSA-180534", "R-SPO-8951664", "R-HSA-2644606", "R-RNO-983168", "R-DDI-187577", "R-BTA-8939902", "R-MMU-69231", "R-SCE-917937", "R-HSA-68949", "R-HSA-5610785", "R-HSA-187577", "R-BTA-8951664", "R-RNO-5676590", "R-MMU-5610780", "R-MMU-187577", "R-BTA-195253", "R-SCE-8854050", "R-BTA-68949", "R-MMU-68949", "R-CEL-8939902", "R-RNO-69601", "R-CEL-983168", "R-MMU-69601", "R-HSA-2565942", "R-CEL-8854050", "R-HSA-2871837", "R-MMU-917937", "R-RNO-5610780", "R-RNO-2565942", "R-MMU-5610785", "R-DDI-69601", "R-MMU-8854050", "R-SPO-983168", "R-SCE-983168", "R-MMU-9762114", "R-HSA-9762114", "R-HSA-5607764", "R-SPO-8854050", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-BTA-5610780", "R-RNO-1170546", "R-HSA-5610780", "R-MMU-1170546", "R-BTA-187577", "R-DDI-917937", "R-DDI-69231", "R-RNO-5684264", "R-HSA-2894862", "R-MMU-1169091", "R-HSA-69601", "R-HSA-983168", "R-RNO-174113", "R-BTA-9929356", "R-BTA-8854050", "R-MMU-5607761", "R-MMU-5676590", "R-RNO-69231", "R-HSA-8939902", "R-DDI-983168", "R-HSA-9725371", "R-HSA-9929356", "R-CEL-69601", "R-CEL-68949", "R-RNO-187577", "R-RNO-5607764", "R-MMU-8939902", "R-CEL-2565942", "R-HSA-917937", "R-BTA-9020702", "R-RNO-1169091", "R-RNO-9762114", "R-RNO-5610785", "R-MMU-983168", "R-HSA-202424", "R-RNO-195253", "R-CEL-9762114", "R-CEL-8951664", "R-RNO-2871837"], "pathways": ["R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9020702:r:Interleukin-1 signaling", "R-BTA-69231:r:Cyclin D associated events in G1", "R-RNO-68949:r:Orc1 removal from chromatin", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-1170546:r:Prolactin receptor signaling", "R-HSA-8951664:r:Neddylation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-69231:r:Cyclin D associated events in G1", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-917937:r:Iron uptake and transport", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-BTA-917937:r:Iron uptake and transport", "R-RNO-8951664:r:Neddylation", "R-DDI-68949:r:Orc1 removal from chromatin", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-69231:r:Cyclin D associated events in G1", "R-SCE-917937:r:Iron uptake and transport", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-8951664:r:Neddylation", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-917937:r:Iron uptake and transport", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-1170546:r:Prolactin receptor signaling", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-1170546:r:Prolactin receptor signaling", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-68949:r:Orc1 removal from chromatin", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-917937:r:Iron uptake and transport", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Family"}, "IPR016898": {"description": "Polyphosphate phosphotransferase", "go_ids": ["GO:0008976"], "go_terms": ["GO:0008976:polyphosphate kinase activity:F"], "name": "Polyphosphate_phosphotransfera", "pathway_ids": ["PWY-7039", "PWY-5107"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-5107:t:phytol salvage pathway"], "type": "Family"}, "IPR016899": {"description": "mRNA cap guanine-N7 methyltransferase, eukaryotes", "go_ids": ["GO:0006370", "GO:0004482"], "go_terms": ["GO:0006370:7-methylguanosine mRNA capping:P", "GO:0004482:mRNA 5'-cap (guanine-N7-)-methyltransferase activity:F"], "name": "mRNA_G-N7_MeTrfase_euk", "pathway_ids": ["PWY-7375", "R-RNO-72086", "R-SPO-77075", "R-XTR-77075", "R-SCE-72086", "R-DRE-72086", "R-CEL-72086", "R-HSA-72086", "R-DME-77075", "R-CEL-77075", "R-DRE-77075", "R-RNO-77075", "R-DME-72086", "R-MMU-77075", "R-SCE-77075", "R-HSA-167160", "R-HSA-77075", "R-MMU-72086", "R-SPO-72086", "R-XTR-72086"], "pathways": ["PWY-7375:t:mRNA capping I", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-XTR-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-72086:r:mRNA Capping", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-72086:r:mRNA Capping", "R-SPO-72086:r:mRNA Capping", "R-XTR-72086:r:mRNA Capping"], "type": "Family"}, "IPR016900": {"description": "Alpha-2-glucosyltransferase Alg10", "go_ids": ["GO:0106073", "GO:0006488"], 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activators between G1/S and early anaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-2467813:r:Separation of Sister Chromatids", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DME-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", 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"name": "TrmL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016915": {"description": "Uncharacterised conserved protein UCP029342", "go_ids": [], "go_terms": [], "name": "UCP029342", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016916": {"description": "Uncharacterised conserved protein UCP029389, subtilisin-related", "go_ids": [], "go_terms": [], "name": "UCP029389_subtilisin-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016917": {"description": "Uncharacterised conserved protein UCP029393", "go_ids": [], "go_terms": [], "name": "UCP029393", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016918": {"description": "Uncharacterised conserved protein UCP029394", "go_ids": [], "go_terms": [], "name": "UCP029394", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016919": {"description": "Uncharacterised conserved protein UCP029416, tyrosine-protein phosphatase, Mlr4629", "go_ids": [], "go_terms": [], "name": "UCP029416_PTP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016920": {"description": "Uncharacterised conserved protein UCP029477", "go_ids": [], "go_terms": [], "name": "UCP029477", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016921": {"description": "Uncharacterised conserved protein UCP029502", "go_ids": [], "go_terms": [], "name": "UCP029502", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016922": {"description": "Uncharacterised conserved protein UCP029505", "go_ids": [], "go_terms": [], "name": "UCP029505", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016923": {"description": "Uncharacterised conserved protein UCP029509, membrane", "go_ids": [], "go_terms": [], "name": "UCP029509", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016924": {"description": "Uncharacterised conserved protein UCP029543", "go_ids": [], "go_terms": [], "name": "UCP029543", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016925": {"description": "Uncharacterised conserved protein UCP029570", "go_ids": [], "go_terms": [], "name": "UCP029570", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016926": {"description": "Uncharacterised conserved protein UCP029594", "go_ids": [], "go_terms": [], "name": "UCP029594", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016927": {"description": "Lectin, sugar-binding", "go_ids": [], "go_terms": [], "name": "Lectin_sugar-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016928": {"description": "Uncharacterised conserved protein UCP029611", "go_ids": [], "go_terms": [], "name": "UCP029611", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016929": {"description": "Imm52 family, TsiT-like", "go_ids": [], "go_terms": [], "name": "TsiT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016930": {"description": "Uncharacterised conserved protein UCP029644, LysM, PA4035", "go_ids": [], "go_terms": [], "name": "UCP029644", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016931": {"description": "Uncharacterised conserved protein UCP029658, TPR", "go_ids": [], "go_terms": [], "name": "UCP029658_TPR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016932": {"description": "Uncharacterised conserved protein UCP029669", "go_ids": [], "go_terms": [], "name": "UCP029669", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016933": {"description": "Pentapeptide repeat-containing uncharacterised conserved protein UCP029688", "go_ids": [], "go_terms": [], "name": "UCP029688_pentapep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016934": {"description": "Uncharacterised conserved protein UCP029691", "go_ids": [], "go_terms": [], "name": "UCP029691", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016935": {"description": "Opine metallophore dehydrogenase", "go_ids": [], "go_terms": [], "name": "Opine_metallophore_DH", "pathway_ids": ["PWY-1723", "PWY-5301", "PWY-8450", "PWY-8451", "PWY-5748", "PWY-7668", "PWY-7667"], "pathways": ["PWY-1723:t:formaldehyde oxidation VI (H4MPT pathway)", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8450:t:pyruvate-derived opine biosynthesis I (bacteria)", "PWY-8451:t:2-oxoglutarate-derived opine biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7667:t:apicidin biosynthesis"], "type": "Family"}, "IPR016936": {"description": "Uncharacterised conserved protein UCP029693", "go_ids": [], "go_terms": [], "name": "UCP029693", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016937": {"description": "Uncharacterised conserved protein UCP029727", "go_ids": [], "go_terms": [], "name": "UCP029727", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016938": {"description": "Uncharacterised protein family UPF0317", "go_ids": [], "go_terms": [], "name": "UPF0317", "pathway_ids": ["PWY-7045", "PWY-8319", "PWY-7811", "PWY-6322", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7814", "PWY-6627", "PWY-6946", "PWY-6945", "PWY-7188", "PWY-5780", "PWY-7897", "PWY-7275", "PWY-5367", "PWY-8152", "PWY-8029", "PWY-6948", "PWY-8134", "PWY-7610", "PWY-7695", "PWY-7354", "PWY-8335", "PWY-6944", "PWY-7547", "PWY-8012", "PWY-2229", "PWY-5793", "PWY-7352", "PWY-2467", "PWY-8044", "PWY-6602", "PWY-6679", "PWY-7757", "PWY-7510", "PWY-5979", "PWY-721", "PWY-5644", "PWY-5408", "PWY-7821", "PWY-7189", "PWY-5410", "PWY-7613", "PWYG-321", "PWY-5061", "PWY-6721", "PWY-6672", "PWY-5409", "PWY-6749", "PWY-7428", "PWY-8151"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-8319:t:NiFe(CO)(CN)2 cofactor biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7188:t:orientin and isoorientin biosynthesis I", "PWY-5780:t:hypericin biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-7275:t:L-homophenylalanine biosynthesis", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-8134:t:bile acid 7beta-dehydroxylation", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-8335:t:plasmalogen biosynthesis II (anaerobic)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7547:t:prodigiosin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-2229:t:superpathway of pterocarpan biosynthesis (via formononetin)", "PWY-5793:t:maysin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-2467:t:(+)-pisatin biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6602:t:naringenin C-glucosylation", "PWY-6679:t:jadomycin biosynthesis", "PWY-7757:t:bisphenol A degradation", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-721:t:3-methylquinoline degradation", "PWY-5644:t:4-nitrotoluene degradation II", "PWY-5408:t:9-lipoxygenase and 9-hydroperoxide lyase pathway", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7189:t:pinocembrin C-glucosylation", "PWY-5410:t:traumatin and (Z)-3-hexen-1-yl acetate biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5061:t:6,7,4'-trihydroxyisoflavone biosynthesis", "PWY-6721:t:sangivamycin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-5409:t:divinyl ether biosynthesis II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7428:t:2-chloroacrylate degradation II", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)"], "type": "Family"}, "IPR016939": {"description": "Small ribosomal subunit protein mS23, fungi", "go_ids": ["GO:0003735", "GO:0005763"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005763:mitochondrial small ribosomal subunit:C"], "name": "Ribosomal_mS23_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016940": {"description": "Competence protein ComGC", "go_ids": ["GO:0030420"], "go_terms": ["GO:0030420:establishment of competence for transformation:P"], "name": "ComGC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016941": {"description": "Uncharacterised conserved protein UCP029962", "go_ids": [], "go_terms": [], "name": "UCP029962", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016942": {"description": "Uncharacterised conserved protein UCP030042", "go_ids": [], "go_terms": [], "name": "UCP030042", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016943": {"description": "Uncharacterised conserved protein UCP030050, HTH transcriptional regulator, BH1869", "go_ids": [], "go_terms": [], "name": "UCP030050_HTH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016944": {"description": "Uncharacterised conserved protein UCP030066", "go_ids": [], "go_terms": [], "name": "UCP030066", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016945": {"description": "Uncharacterised conserved protein UCP030092", "go_ids": [], "go_terms": [], "name": "UCP030092", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016946": {"description": "Uncharacterised conserved protein UCP030125", "go_ids": [], "go_terms": [], "name": "UCP030125", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016947": {"description": "Uncharacterised phage-associated protein UCP030140", "go_ids": [], "go_terms": [], "name": "UCP030140", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016948": {"description": "Uncharacterised conserved protein UCP030175", "go_ids": [], "go_terms": [], "name": "UCP030175", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016949": {"description": "Damage-control phosphatase At2g17340", "go_ids": [], "go_terms": [], "name": "At2g17340", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016950": {"description": "Mannosyltransferase, MA4085, predicted", "go_ids": [], "go_terms": [], "name": "Manno-Trfase_MA4085_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016951": {"description": "Haem oxygenase (decyclizing), plant", "go_ids": [], "go_terms": [], "name": "Haem_Oase_decyc_pln", "pathway_ids": ["PWY-5874"], "pathways": ["PWY-5874:t:heme degradation I"], "type": "Family"}, "IPR016952": {"description": "Small heat shock protein, predicted, plant", "go_ids": [], "go_terms": [], "name": "Small_heat_shock_prot_prd_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016953": {"description": "Uncharacterised conserved protein UCP030365", "go_ids": [], "go_terms": [], "name": "UCP030365", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016954": {"description": "Uncharacterised protein family, Vng0742h", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Vng0742h", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016955": {"description": "Autotransporter, YhjY, predicted", "go_ids": [], "go_terms": [], "name": "Autotranspt_YhjY_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016956": {"description": "Inner membrane protein YdjM", "go_ids": [], "go_terms": [], "name": "YdjM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016957": {"description": "Uncharacterised conserved protein UCP030791", "go_ids": [], "go_terms": [], "name": "UCP030791", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016958": {"description": "Uncharacterised conserved protein UCP030798", "go_ids": [], "go_terms": [], "name": "UCP030798", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016959": {"description": "Uncharacterised conserved protein UCP030811", "go_ids": [], "go_terms": [], "name": "UCP030811", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016960": {"description": "Protein kinase YegI-like", "go_ids": [], "go_terms": [], "name": "YegI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016961": {"description": "Diacylglycerol kinase, plant", "go_ids": ["GO:0004143"], "go_terms": ["GO:0004143:ATP-dependent diacylglycerol kinase activity:F"], "name": "Diacylglycerol_kinase_pln", "pathway_ids": ["PWY-7039", "PWY-7817"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)"], "type": "Family"}, "IPR016962": {"description": "Dehydrase, ECs4332, predicted", "go_ids": [], "go_terms": [], "name": "Dehydrase_ECs4332_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016963": {"description": "Glycoporin RafY", "go_ids": [], "go_terms": [], "name": "Glycoporin_RafY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016964": {"description": "Sigma intracellular receptor 2", "go_ids": [], "go_terms": [], "name": "Sigma2_recept", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016965": {"description": "Phosphatase PHOSPHO-type", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "Pase_PHOSPHO-typ", "pathway_ids": ["R-HSA-1483191", "R-HSA-1483213", "R-MMU-1483213", "R-DRE-1483191", "R-MMU-1483191", "R-DRE-1483213"], "pathways": ["R-HSA-1483191:r:Synthesis of PC", "R-HSA-1483213:r:Synthesis of PE", "R-MMU-1483213:r:Synthesis of PE", "R-DRE-1483191:r:Synthesis of PC", "R-MMU-1483191:r:Synthesis of PC", "R-DRE-1483213:r:Synthesis of PE"], "type": "Family"}, "IPR016966": {"description": "Thiamin pyrophosphokinase, eukaryotic", "go_ids": ["GO:0004788", "GO:0005524", "GO:0009229"], "go_terms": ["GO:0004788:thiamine diphosphokinase activity:F", "GO:0005524:ATP binding:F", "GO:0009229:thiamine diphosphate biosynthetic process:P"], "name": "Thiamin_pyrophosphokinase_euk", "pathway_ids": ["PWY-6898", "PWY-6908", "PWY-6907", "PWY-7356", "R-BTA-196819", "R-HSA-196819", "R-SCE-196819", "R-CEL-196819", "R-MMU-196819"], "pathways": ["PWY-6898:t:thiamine diphosphate salvage III", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-SCE-196819:r:Vitamin B1 (thiamin) metabolism", "R-CEL-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Family"}, "IPR016968": {"description": "Uncharacterised conserved protein UCP031074", "go_ids": [], "go_terms": [], "name": "UCP031074", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016969": {"description": "Uncharacterised conserved protein UCP031088, alpha/beta hydrolase, At1g15070", "go_ids": [], "go_terms": [], "name": "UCP031088_abhydr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016970": {"description": "Uncharacterised conserved protein UCP031143", "go_ids": [], "go_terms": [], "name": "UCP031143", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016971": {"description": "Uncharacterised conserved protein UCP031277", "go_ids": [], "go_terms": [], "name": "UCP031277", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016972": {"description": "Uncharacterised conserved protein UCP031279", "go_ids": [], "go_terms": [], "name": "UCP031279", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016973": {"description": "Integral membrane protein SYS1", "go_ids": ["GO:0000139"], "go_terms": ["GO:0000139:Golgi membrane:C"], "name": "Integral_membrane_SYS1", "pathway_ids": ["R-HSA-6811440", "R-BTA-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR016974": {"description": "Uncharacterised phage-associated protein", "go_ids": [], "go_terms": [], "name": "Uncharacterised_phage-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016975": {"description": "Cell wall-active antibiotic response protein LiaF", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Cell_wall_LiaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016976": {"description": "Uncharacterised conserved protein UCP031601", "go_ids": [], "go_terms": [], "name": "UCP031601", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016977": {"description": "Competence protein ComGF", "go_ids": [], "go_terms": [], "name": "ComGF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016978": {"description": "Putative competence-induced protein Ccs4, streptococcus", "go_ids": [], "go_terms": [], "name": "Competence-induced_Ccs4_sc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016979": {"description": "Protein of unknown function DUF2129", "go_ids": [], "go_terms": [], "name": "DUF2129", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016980": {"description": "S-adenosyl-L-methionine dependent methyltransferase, Alr7345, predicted", "go_ids": [], "go_terms": [], "name": "S-AdoMet-dep_MeTrfase_Alr7345", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016981": {"description": "Transcription regulator, AraC, predicted", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_031684_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016982": {"description": "Probable magnetosome protein Mms48", "go_ids": [], "go_terms": [], "name": "Mms48", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016983": {"description": "Uncharacterised conserved protein UCP031804", "go_ids": [], "go_terms": [], "name": "UCP031804", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016984": {"description": "Uncharacterised conserved protein UCP031853", "go_ids": [], "go_terms": [], "name": "UCP031853", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016985": {"description": "Tim44-like protein TimA", "go_ids": [], "go_terms": [], "name": "TimA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016986": {"description": "Uncharacterised conserved protein UCP031982, alpha/beta hydrolase, XabL", "go_ids": [], "go_terms": [], "name": "UCP031982_abhydr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016987": {"description": "Uncharacterised conserved protein UCP023238", "go_ids": [], "go_terms": [], "name": "UCP023238", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016988": {"description": "Uncharacterised conserved protein UCP032086", "go_ids": [], "go_terms": [], "name": "UCP032086", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016989": {"description": "ATP synthase protein I, alphaproteobacterial", "go_ids": [], "go_terms": [], "name": "Atp1_alphaprobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016990": {"description": "Uncharacterised conserved protein UCP032162, transmembrane", "go_ids": [], "go_terms": [], "name": "UCP032162_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016991": {"description": "Protein of unknown function UCP032178", "go_ids": [], "go_terms": [], "name": "UCP032178", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016992": {"description": "Uncharacterised conserved protein UCP032209", "go_ids": [], "go_terms": [], "name": "UCP032209", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016993": {"description": "Predicted glycerophosphotransferase, SA2157 type", "go_ids": [], "go_terms": [], "name": "SA2157_glycerophostrnsf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016994": {"description": "VraC", "go_ids": [], "go_terms": [], "name": "VraC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016995": {"description": "Dimeric dUTPase Dut-like", "go_ids": [], "go_terms": [], "name": "Dimeric_Dut-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016996": {"description": "Uncharacterised conserved protein UCP032441", "go_ids": [], "go_terms": [], "name": "UCP032441", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016997": {"description": "Uncharacterised conserved protein UCP032442", "go_ids": [], "go_terms": [], "name": "UCP032442", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016998": {"description": "HTH-type transcriptional regulator Rot", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "Rot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR016999": {"description": "L-serine kinase SbnI-like", "go_ids": [], "go_terms": [], "name": "SbnI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017000": {"description": "Membrane-anchored ubiquitin-fold protein", "go_ids": [], "go_terms": [], "name": "MUB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017001": {"description": "Peptidase S53, physarolisin II, archaeal-type", "go_ids": [], "go_terms": [], "name": "Pept_S53_physarolisin-II_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017002": {"description": "Glycoside hydrolase, family 57, Saci1162, predicted", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_57_Saci1162_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017003": {"description": "Uncharacterised conserved protein UCP032675", "go_ids": [], "go_terms": [], "name": "UCP032675", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017004": {"description": "Uncharacterised conserved protein UCP032676, PqqC", "go_ids": [], "go_terms": [], "name": "UCP032676_PqqC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017005": {"description": "Uncharacterised conserved protein UCP032748", "go_ids": [], "go_terms": [], "name": "UCP032748", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017006": {"description": "Uncharacterised conserved protein UCP032756", "go_ids": [], "go_terms": [], "name": "UCP032756", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017007": {"description": "Uncharacterised conserved protein UCP032762", "go_ids": [], "go_terms": [], "name": "UCP032762", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017008": {"description": "UCP032817-like, proteobacteria", "go_ids": [], "go_terms": [], "name": "UCP032817-like_proteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017009": {"description": "Uncharacterised conserved protein UCP032840", "go_ids": [], "go_terms": [], "name": "UCP032840", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017010": {"description": "Uncharacterised conserved protein UCP032862, iron-sulphur-binding domain-type, SSO0018", "go_ids": [], "go_terms": [], "name": "UCP032862_Fe-S-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017011": {"description": "Uncharacterised conserved protein UCP032888", "go_ids": [], "go_terms": [], "name": "UCP032888", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017012": {"description": "Uncharacterised conserved protein UCP032899, lipoprotein", "go_ids": [], "go_terms": [], "name": "UCP032899", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017013": {"description": "Cell division control protein 45 homolog, archaea", "go_ids": [], "go_terms": [], "name": "Cdc45_arch", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017014": {"description": "Fimbrial-like protein YadC", "go_ids": [], "go_terms": [], "name": "Fimbrial-like_YadC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017015": {"description": "Uncharacterised conserved protein UCP033367, VanZ, Bll3170", "go_ids": [], "go_terms": [], "name": "UCP033367_VanZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017016": {"description": "Uncharacterised conserved protein UCP033595", "go_ids": [], "go_terms": [], "name": "UCP033595", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017017": {"description": "Uncharacterised conserved protein UCP033622, transglutaminase-like, CPE1922", "go_ids": [], "go_terms": [], "name": "UCP033622_transglutaminase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017018": {"description": "Uncharacterised conserved protein UCP033634", "go_ids": [], "go_terms": [], "name": "UCP033634", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017019": {"description": "Predicted DNA replication protein, bacterial", "go_ids": [], "go_terms": [], "name": "DNA_replication_prd_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017020": {"description": "Uncharacterised conserved protein UCP033725", "go_ids": [], "go_terms": [], "name": "UCP033725", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017021": {"description": "Uncharacterised conserved protein UCP033763", "go_ids": [], "go_terms": [], "name": "UCP033763", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017022": {"description": "Uncharacterised conserved protein UCP033860", "go_ids": [], "go_terms": [], "name": "UCP033860", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017023": {"description": "Uncharacterised conserved protein UCP034039", "go_ids": [], "go_terms": [], "name": "UCP034039", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017024": {"description": "Uncharacterized protein Atu0565-like", "go_ids": [], "go_terms": [], "name": "Atu0565", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017025": {"description": "Cancer-associated antigen RCAS1", "go_ids": [], "go_terms": [], "name": "Cancer-assoc_antigen_RCAS1", "pathway_ids": ["R-HSA-9018519"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Family"}, "IPR017026": {"description": "Inducible mutagenesis protein A", "go_ids": [], "go_terms": [], "name": "ImuA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017027": {"description": "STM3548-like", "go_ids": [], "go_terms": [], "name": "STM3548-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017028": {"description": "Uncharacterised conserved protein UCP034456", "go_ids": [], "go_terms": [], "name": "UCP034456", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017029": {"description": "Putative phage head morphogenesis protein", "go_ids": [], "go_terms": [], "name": "Phage_head_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017030": {"description": "Virulence effector, SrfC", "go_ids": [], "go_terms": [], "name": "Vir_effector_SrfC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017031": {"description": "Predicted S-adenosyl-L-methionine dependent methyltransferase, YjhP-type", "go_ids": [], "go_terms": [], "name": "Pre_MeTrfase_YjhP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017032": {"description": "Vi polysaccharide biosynthesis protein TviA", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "TviA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017033": {"description": "Type III secretion system apparatus protein SsaM", "go_ids": [], "go_terms": [], "name": "T3SS_SsaM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017034": {"description": "Abortive infection system protein AbiD/AbiF", "go_ids": [], "go_terms": [], "name": "Abi_system_AbiD/AbiF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017035": {"description": "Uncharacterised conserved protein UCP035009, HsdR, All3000-type", "go_ids": [], "go_terms": [], "name": "UCP035009_HsdR_All3000-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017036": {"description": "Lmo0553-like", "go_ids": [], "go_terms": [], "name": "Lmo0553-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017037": {"description": "Uncharacterised conserved protein UCP035261", "go_ids": [], "go_terms": [], "name": "UCP035261", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017038": {"description": "Uncharacterised conserved protein UCP035609, HNH endonuclease-type", "go_ids": [], "go_terms": [], "name": "UCP035609_HNH_endonucl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017039": {"description": "Virulence factor BrkB", "go_ids": [], "go_terms": [], "name": "Virul_fac_BrkB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017040": {"description": "Uncharacterised conserved protein UCP035918 , rubrerythrin/DUF125-related", "go_ids": [], "go_terms": [], "name": "UCP035918_rubreryth/DUF125", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017041": {"description": "Uncharacterised conserved protein UCP036054", "go_ids": [], "go_terms": [], "name": "UCP036054", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017042": {"description": "Uncharacterised conserved protein UCP036055", "go_ids": [], "go_terms": [], "name": "UCP036055", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017043": {"description": "Type I restriction-modification system, specificity subunit, predicted", "go_ids": [], "go_terms": [], "name": "HsdS_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017044": {"description": "Uncharacterised conserved protein UCP036238", "go_ids": [], "go_terms": [], "name": "UCP036238", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017045": {"description": "Maltose phosphorylase/glycosyl hydrolase/vacuolar acid trehalase", "go_ids": [], "go_terms": [], "name": "Malt_Pase/Glycosyl_Hdrlase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017046": {"description": "Prenylcysteine oxidase 1", "go_ids": ["GO:0001735"], "go_terms": ["GO:0001735:prenylcysteine oxidase activity:F"], "name": "Prenylcysteine_Oxase1", "pathway_ids": ["R-HSA-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR017047": {"description": "Cripto", "go_ids": ["GO:0008083"], "go_terms": ["GO:0008083:growth factor activity:F"], "name": "Cripto", "pathway_ids": ["R-HSA-1181150", "R-HSA-2892247", "R-HSA-1433617"], "pathways": ["R-HSA-1181150:r:Signaling by NODAL", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-HSA-1433617:r:Regulation of signaling by NODAL"], "type": "Family"}, "IPR017048": {"description": "Fibulin-1", "go_ids": ["GO:0030198", "GO:0016504"], "go_terms": ["GO:0030198:extracellular matrix organization:P", "GO:0016504:peptidase activator activity:F"], "name": "Fibulin-1", "pathway_ids": ["R-CEL-216083", "R-CEL-1474228", "R-CEL-2129379", "R-CEL-381426", "R-CEL-1566948", "R-CEL-2173789", "R-HSA-2129379", "R-CEL-8957275"], "pathways": ["R-CEL-216083:r:Integrin cell surface interactions", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-1566948:r:Elastic fibre formation", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-CEL-8957275:r:Post-translational protein phosphorylation"], "type": "Family"}, "IPR017049": {"description": "Low density lipoprotein receptor-related protein 5/6", "go_ids": ["GO:0017147", "GO:0060070", "GO:0042813"], "go_terms": ["GO:0017147:Wnt-protein binding:F", "GO:0060070:canonical Wnt signaling pathway:P", "GO:0042813:Wnt receptor activity:F"], "name": "LRP5/6", "pathway_ids": ["R-HSA-3772470", "R-HSA-201681", "R-MMU-3772470", "R-MMU-4641263", "R-HSA-5339717", "R-HSA-4641263", "R-HSA-4641262", "R-MMU-4641262", "R-HSA-5340588"], "pathways": ["R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5340588:r:Signaling by RNF43 mutants"], "type": "Family"}, "IPR017050": {"description": "Metallopeptidase, nematode", "go_ids": ["GO:0018996", "GO:0008237"], "go_terms": ["GO:0018996:molting cycle, collagen and cuticulin-based cuticle:P", "GO:0008237:metallopeptidase activity:F"], "name": "Metallopeptidase_nem", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR017051": {"description": "Peptidase S1A, matripase", "go_ids": ["GO:0004252", "GO:0006508", "GO:0016020"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0016020:membrane:C"], "name": "Peptidase_S1A_matripase", "pathway_ids": ["R-HSA-6809371"], "pathways": ["R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Family"}, "IPR017052": {"description": "Atrial natriuretic peptide-converting enzyme corin", "go_ids": ["GO:0008217", "GO:0016486", "GO:0004252"], "go_terms": ["GO:0008217:regulation of blood pressure:P", "GO:0016486:peptide hormone processing:P", "GO:0004252:serine-type endopeptidase activity:F"], "name": "Corin", "pathway_ids": ["PWY-7884", "R-HSA-5578768", "R-MMU-5578768", "R-RNO-5578768"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-HSA-5578768:r:Physiological factors", "R-MMU-5578768:r:Physiological factors", "R-RNO-5578768:r:Physiological factors"], "type": "Family"}, "IPR017053": {"description": "Response regulator B-type, plant", "go_ids": ["GO:0009736", "GO:0003677", "GO:0003700"], "go_terms": ["GO:0009736:cytokinin-activated signaling pathway:P", "GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "Response_reg_B-typ_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017054": {"description": "Cobalamin reductase PduS", "go_ids": [], "go_terms": [], "name": "PduS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017055": {"description": "Signal transduction histidine kinase, DctB (C4-dicarboxylate transport system regulator)", "go_ids": [], "go_terms": [], "name": "Sig_transdc_His_kinase_DctB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017056": {"description": "Phosphoesterase, HI0762, predicted", "go_ids": [], "go_terms": [], "name": "P-Estase_HI0762_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017057": {"description": "Ent-kaurene synthase, fungal", "go_ids": ["GO:0016838"], "go_terms": ["GO:0016838:carbon-oxygen lyase activity, acting on phosphates:F"], "name": "Ent-kaurene_synthase_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017058": {"description": "Major membrane immunogen, tpp15, predicted", "go_ids": [], "go_terms": [], "name": "Major_M_immunogen_Tpp15_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017059": {"description": "[NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaH, predicted", "go_ids": [], "go_terms": [], "name": "NiFe-hyd_3_EhaH_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017064": {"description": "Acid sphingomyelinase-like phosphodiesterase, predicted", "go_ids": ["GO:0004767", "GO:0005576", "GO:0006685"], "go_terms": ["GO:0004767:sphingomyelin phosphodiesterase activity:F", "GO:0005576:extracellular region:C", "GO:0006685:sphingomyelin catabolic process:P"], "name": "ASM-like_Pdiesterase_prd", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I"], "type": "Family"}, "IPR017067": {"description": "Ribonuclease H1, eukaryote", "go_ids": ["GO:0000287", "GO:0004523"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0004523:RNA-DNA hybrid ribonuclease activity:F"], "name": "RNase_H1_euk", "pathway_ids": ["R-HSA-9913635"], "pathways": ["R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Family"}, "IPR017068": {"description": "Protein disulphide-isomerase A4", "go_ids": ["GO:0003756", "GO:0005788"], "go_terms": ["GO:0003756:protein disulfide isomerase activity:F", "GO:0005788:endoplasmic reticulum lumen:C"], "name": "Protein_diS-isomerase_A4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017069": {"description": "Maltodextrin glucosidase", "go_ids": ["GO:0005737", "GO:0005975", "GO:0004558"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0005975:carbohydrate metabolic process:P", "GO:0004558:alpha-1,4-glucosidase activity:F"], "name": "MalZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017070": {"description": "Uncharacterised conserved protein UCP036920, phosphoglycerate mutase, plant X4/Y4", "go_ids": [], "go_terms": [], "name": "UCP036920_PGAM-like_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017071": {"description": "Transcription elongation factor Spt5, eukaryote", "go_ids": ["GO:0006357", "GO:0032784"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0032784:regulation of DNA-templated transcription elongation:P"], "name": "TF_Spt5_eukaryote", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-GGA-112382", "R-HSA-167238", "R-GGA-75955", "R-MMU-113418", "R-GGA-674695", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DME-77075", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-DRE-6807505", "R-DRE-77075", "R-HSA-167287", "R-DRE-75955", "R-HSA-167246", "R-DRE-6796648", "R-DME-72086", "R-DRE-113418", "R-HSA-167152", "R-HSA-113418", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-GGA-6796648", "R-SCE-6796648", "R-SPO-113418", "R-DME-113418", "R-SPO-77075", "R-CEL-75955", "R-MMU-6796648", "R-GGA-6807505", "R-DME-674695", "R-HSA-167243", "R-SCE-113418", "R-SCE-72086", "R-DRE-72086", "R-HSA-167242", "R-CEL-113418", "R-CEL-77075", "R-MMU-674695", "R-MMU-6807505", "R-CEL-674695", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-DRE-674695", "R-MMU-77075", "R-HSA-75955", "R-SCE-77075", "R-CEL-112382", "R-HSA-167160", "R-SCE-674695", "R-MMU-72086", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-GGA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-GGA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-72086:r:mRNA Capping", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-GGA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II 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"pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017124": {"description": "PR-domain zinc finger protein PRDM4", "go_ids": ["GO:0006366", "GO:1990226"], "go_terms": ["GO:0006366:transcription by RNA polymerase II:P", "GO:1990226:histone methyltransferase binding:F"], "name": "PRDM4", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-193670"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-193670:r:p75NTR negatively regulates cell cycle via SC1"], "type": "Family"}, "IPR017125": {"description": "PR-domain zinc finger protein PRDM5-like", "go_ids": ["GO:0000976"], "go_terms": ["GO:0000976:transcription cis-regulatory region binding:F"], "name": "Znf_PRDM5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017126": {"description": "PR-domain zinc finger protein PRDM12", "go_ids": [], "go_terms": [], "name": "Znf_PRDM12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017127": {"description": "Ribosomal protein uL3 glutamine methyltransferase", "go_ids": ["GO:0036009"], "go_terms": ["GO:0036009:protein-glutamine N-methyltransferase activity:F"], "name": "Ribosome_uL3_MTase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017128": {"description": "Catechol O-methyltransferase, eukaryotic", "go_ids": ["GO:0000287", "GO:0006584", "GO:0016206"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0006584:catecholamine metabolic process:P", "GO:0016206:catechol O-methyltransferase activity:F"], "name": "Catechol_O-MeTrfase_euk", "pathway_ids": ["PWY-7076", "PWY-5426", "PWY-6342", "PWY-6334", "R-BTA-379398", "R-BTA-156581", "R-BTA-379397", "R-RNO-379398", "R-MMU-379397", "R-RNO-379397", "R-DRE-156581", "R-DRE-379398", "R-RNO-156581", "R-HSA-156581", "R-MMU-379398", "R-HSA-379397", "R-HSA-9679191", "R-MMU-156581", "R-HSA-379398", "R-DRE-379397"], "pathways": ["PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-5426:t:betaxanthin biosynthesis", "PWY-6342:t:noradrenaline and adrenaline degradation", "PWY-6334:t:L-dopa degradation I (mammalian)", "R-BTA-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-BTA-156581:r:Methylation", "R-BTA-379397:r:Enzymatic degradation of dopamine by COMT", "R-RNO-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-MMU-379397:r:Enzymatic degradation of dopamine by COMT", "R-RNO-379397:r:Enzymatic degradation of dopamine by COMT", "R-DRE-156581:r:Methylation", "R-DRE-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-RNO-156581:r:Methylation", "R-HSA-156581:r:Methylation", "R-MMU-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-HSA-379397:r:Enzymatic degradation of dopamine by COMT", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-156581:r:Methylation", "R-HSA-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-DRE-379397:r:Enzymatic degradation of dopamine by COMT"], "type": "Family"}, "IPR017129": {"description": "Bifunctional hydroxyisourate hydrolase/2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase", "go_ids": [], "go_terms": [], "name": "HIU_hydrol/OHCU_decarb", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017130": {"description": "Cholesteryl ester transfer", "go_ids": ["GO:0120020", "GO:0034364", "GO:0043691"], "go_terms": ["GO:0120020:cholesterol transfer activity:F", "GO:0034364:high-density lipoprotein particle:C", "GO:0043691:reverse cholesterol transport:P"], "name": "Cholesteryl_ester_transfer", "pathway_ids": ["R-HSA-8964041", "R-HSA-8964058", "R-HSA-9029569"], "pathways": ["R-HSA-8964041:r:LDL remodeling", "R-HSA-8964058:r:HDL remodeling", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "type": "Family"}, "IPR017131": {"description": "Small ribonucleoprotein associated, SmB/SmN", "go_ids": [], "go_terms": [], "name": "snRNP-assoc_SmB/SmN", "pathway_ids": ["R-HSA-191859", "R-MMU-77588", "R-MMU-9770562", "R-GGA-73856", "R-HSA-73856", "R-DME-72163", "R-RNO-72163", "R-RNO-73856", "R-DME-9770562", "R-RNO-191859", "R-GGA-72163", "R-RNO-72165", "R-HSA-77588", "R-HSA-111367", "R-HSA-72165", "R-DME-73856", "R-GGA-9770562", "R-HSA-9918481", "R-MMU-191859", "R-BTA-72163", "R-GGA-72165", "R-HSA-9770562", "R-MMU-72163", "R-MMU-73856", "R-HSA-9754678", "R-GGA-111367", "R-RNO-111367", "R-HSA-72163", "R-DME-72165", "R-MMU-72165", "R-RNO-9770562", "R-MMU-111367", "R-BTA-9770562", "R-DME-77588", "R-RNO-77588", "R-GGA-191859", "R-DME-111367", "R-GGA-77588"], "pathways": ["R-HSA-191859:r:snRNP Assembly", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DME-9770562:r:mRNA Polyadenylation", "R-RNO-191859:r:snRNP Assembly", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-GGA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-191859:r:snRNP Assembly", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-GGA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-GGA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-RNO-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-BTA-9770562:r:mRNA Polyadenylation", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-RNO-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-GGA-191859:r:snRNP Assembly", "R-DME-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-GGA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "type": "Family"}, "IPR017133": {"description": "L-tyrosine isonitrile synthase", "go_ids": [], "go_terms": [], "name": "PvcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017134": {"description": "Ubiquitin-protein ligase E3A", "go_ids": ["GO:0061630", "GO:0006511"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0006511:ubiquitin-dependent protein catabolic process:P"], "name": "UBE3A", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR017135": {"description": "D-glutamate cyclase, mitochondrial", "go_ids": [], "go_terms": [], "name": "D-Glu_cyclase_mito", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017136": {"description": "Uncharacterised conserved protein UCP037205", "go_ids": [], "go_terms": [], "name": "UCP037205", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017137": {"description": "Arginine-tRNA-protein transferase 1, eukaryotic", "go_ids": ["GO:0004057", "GO:0016598"], "go_terms": ["GO:0004057:arginyl-tRNA--protein transferase activity:F", "GO:0016598:protein arginylation:P"], "name": "Arg-tRNA-P_Trfase_1_euk", "pathway_ids": ["PWY-7799"], "pathways": ["PWY-7799:t:Arg/N-end rule pathway (eukaryotic)"], "type": "Family"}, "IPR017138": {"description": "Aspartate/glutamate leucyltransferase", "go_ids": ["GO:0008914", "GO:0071596"], "go_terms": ["GO:0008914:leucyl-tRNA--protein transferase activity:F", "GO:0071596:ubiquitin-dependent protein catabolic process via the N-end rule pathway:P"], "name": "Asp_Glu_LeuTrfase", "pathway_ids": ["PWY-7802"], "pathways": ["PWY-7802:t:N-end rule pathway II (prokaryotic)"], "type": "Family"}, "IPR017139": {"description": "Uncharacterised conserved protein UCP037213", "go_ids": [], "go_terms": [], "name": "UCP037213", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017140": {"description": "ThermoDBP-related, archaea", "go_ids": [], "go_terms": [], "name": "ThermoDBP-RPs_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017141": {"description": "Peptidase M20, carboxypeptidase S", "go_ids": ["GO:0004181"], "go_terms": ["GO:0004181:metallocarboxypeptidase activity:F"], "name": "Pept_M20_carboxypep", "pathway_ids": ["R-SPO-9673163", "R-SCE-9673163", "R-DRE-9673163"], "pathways": ["R-SPO-9673163:r:Oleoyl-phe metabolism", "R-SCE-9673163:r:Oleoyl-phe metabolism", "R-DRE-9673163:r:Oleoyl-phe metabolism"], "type": "Family"}, "IPR017142": {"description": "Nitric oxide synthase, oxygenase subunit", "go_ids": ["GO:0004517", "GO:0006809", "GO:0020037"], "go_terms": ["GO:0004517:nitric-oxide synthase activity:F", "GO:0006809:nitric oxide biosynthetic process:P", "GO:0020037:heme binding:F"], "name": "Nitric_oxide_synthase_Oase-su", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017143": {"description": "Uncharacterised conserved protein UCP037225", "go_ids": [], "go_terms": [], "name": "UCP037225", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017144": {"description": "Xaa-Arg dipeptidase", "go_ids": ["GO:0016805"], "go_terms": ["GO:0016805:dipeptidase activity:F"], "name": "Xaa-Arg_dipeptidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017145": {"description": "Aminobenzoyl-glutamate utilization protein B", "go_ids": [], "go_terms": [], "name": "Aminobenzoyl-glu_utiliz_pB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017146": {"description": "Type 2 lantibiotic biosynthesis protein LanM", "go_ids": [], "go_terms": [], "name": "Lanti_2_LanM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017147": {"description": "Tricalbin", "go_ids": [], "go_terms": [], "name": "Tricalbin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017148": {"description": "Vacuolar protein sorting-associated protein 13, fungi", "go_ids": [], "go_terms": [], "name": "VPS13_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017149": {"description": "Glutathione degradosome, Dug2", "go_ids": ["GO:0006751"], "go_terms": ["GO:0006751:glutathione catabolic process:P"], "name": "GSH_degradosome_Dug2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017150": {"description": "Peptidase M20, glutamate carboxypeptidase", "go_ids": [], "go_terms": [], "name": "Pept_M20_glutamate_carboxypep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017151": {"description": "5'-3' exoribonuclease type 2", "go_ids": ["GO:0004534", "GO:0005634", "GO:0006139"], "go_terms": ["GO:0004534:5'-3' RNA exonuclease activity:F", "GO:0005634:nucleus:C", "GO:0006139:nucleobase-containing compound metabolic process:P"], "name": "Xrn2/3/4", "pathway_ids": ["R-GGA-6791226", "R-MMU-6791226", "R-HSA-9930044", "R-HSA-9770562", "R-HSA-390471", "R-HSA-6791226"], "pathways": ["R-GGA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR017153": {"description": "Cytosolic nonspecific dipeptidase/DUG1", "go_ids": ["GO:0070573"], "go_terms": ["GO:0070573:metallodipeptidase activity:F"], "name": "CNDP/DUG1", "pathway_ids": ["R-MMU-9753281", "R-RNO-174403", "R-BTA-174403", "R-RNO-9753281", "R-MMU-174403", "R-SPO-174403", "R-HSA-9753281", "R-SCE-9753281", "R-SPO-9753281", "R-HSA-174403", "R-BTA-9753281", "R-SCE-174403"], "pathways": ["R-MMU-9753281:r:Paracetamol ADME", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-RNO-9753281:r:Paracetamol ADME", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-HSA-9753281:r:Paracetamol ADME", "R-SCE-9753281:r:Paracetamol ADME", "R-SPO-9753281:r:Paracetamol ADME", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-BTA-9753281:r:Paracetamol ADME", "R-SCE-174403:r:Glutathione synthesis and recycling"], "type": "Family"}, "IPR017154": {"description": "PC4-like", "go_ids": [], "go_terms": [], "name": "PC4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017155": {"description": "Histone-lysine N-methyltransferase SETD7", "go_ids": ["GO:0140945", "GO:0005694", "GO:0006355", "GO:0016279"], "go_terms": ["GO:0140945:histone H3K4 monomethyltransferase activity:F", "GO:0005694:chromosome:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016279:protein-lysine N-methyltransferase activity:F"], "name": "Hist-Lys_N-MeTrfase_SETD7", "pathway_ids": ["R-HSA-3214841", "R-MMU-3214841", "R-DRE-3214841"], "pathways": ["R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines"], "type": "Family"}, "IPR017156": {"description": "Carboxysome assembly protein CcmM", "go_ids": ["GO:0043886"], "go_terms": ["GO:0043886:structural constituent of carboxysome shell:F"], "name": "CcmM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017157": {"description": "Arylacetamide deacetylase", "go_ids": ["GO:0016020", "GO:0052689"], "go_terms": ["GO:0016020:membrane:C", "GO:0052689:carboxylic ester hydrolase activity:F"], "name": "Arylacetamide_deacetylase", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521", "R-RNO-211945", "R-HSA-211945", "R-BTA-8964038", "R-RNO-8964038", "R-HSA-8964038", "R-MMU-8964038", "R-MMU-211945"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-BTA-8964038:r:LDL clearance", "R-RNO-8964038:r:LDL clearance", "R-HSA-8964038:r:LDL clearance", "R-MMU-8964038:r:LDL clearance", "R-MMU-211945:r:Phase I - Functionalization of compounds"], "type": "Family"}, "IPR017158": {"description": "Transcription regulator, CBS domain-containing, predicted", "go_ids": [], "go_terms": [], "name": "Tscrpt-reg_CBS-contain_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017159": {"description": "Gremlin-1/2", "go_ids": [], "go_terms": [], "name": "Gremlin-1/2", "pathway_ids": ["R-MMU-201451", "R-HSA-9830674", "R-HSA-201451"], "pathways": ["R-MMU-201451:r:Signaling by BMP", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-201451:r:Signaling by BMP"], "type": "Family"}, "IPR017160": {"description": "Uncharacterised conserved protein UCP037256", "go_ids": [], "go_terms": [], "name": "UCP037256", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017162": {"description": "Uncharacterised conserved protein UCP037266", "go_ids": [], "go_terms": [], "name": "UCP037266", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017163": {"description": "Phosphatidylinositol-4-phosphate 5-kinase, plant", "go_ids": ["GO:0005524", "GO:0016308"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016308:1-phosphatidylinositol-4-phosphate 5-kinase activity:F"], "name": "PIno-4-P-5_kinase_pln", "pathway_ids": ["PWY-6351", "PWY-6352"], "pathways": ["PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis"], "type": "Family"}, "IPR017164": {"description": "Wee1-like protein kinase", "go_ids": ["GO:0000287", "GO:0004715", "GO:0005634", "GO:0000278"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0004715:non-membrane spanning protein tyrosine kinase activity:F", "GO:0005634:nucleus:C", "GO:0000278:mitotic cell cycle:P"], "name": "Wee1-like_protein_kinase", "pathway_ids": ["R-DME-69273", "R-RNO-69202", "R-MMU-156711", "R-DME-69202", "R-HSA-69478", "R-RNO-156711", "R-HSA-156711", "R-HSA-69273", "R-HSA-983231", "R-DME-156711", "R-RNO-75035", "R-MMU-75035", "R-RNO-69478", "R-DME-69478", "R-RNO-69273", "R-MMU-69478", "R-MMU-69202", "R-MMU-69656", "R-HSA-75035", "R-HSA-69656", "R-RNO-69656", "R-DME-75035", "R-MMU-69273", "R-HSA-69202", "R-DME-69656"], "pathways": ["R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-156711:r:Polo-like kinase mediated events", "R-DME-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-69478:r:G2/M DNA replication checkpoint", "R-RNO-156711:r:Polo-like kinase mediated events", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-156711:r:Polo-like kinase mediated events", "R-RNO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-69478:r:G2/M DNA replication checkpoint", "R-DME-69478:r:G2/M DNA replication checkpoint", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-69478:r:G2/M DNA replication checkpoint", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DME-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry"], "type": "Family"}, "IPR017166": {"description": "Uncharacterised conserved protein UCP037290", "go_ids": [], "go_terms": [], "name": "UCP037290", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017167": {"description": "Uncharacterised conserved protein UCP037291, glutaredoxin-related", "go_ids": [], "go_terms": [], "name": "UCP037291_glutaredoxin-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017168": {"description": "CRH-like", "go_ids": ["GO:0005618", "GO:0016798", "GO:0071555"], "go_terms": ["GO:0005618:cell wall:C", "GO:0016798:hydrolase activity, acting on glycosyl bonds:F", "GO:0071555:cell wall organization:P"], "name": "CHR-like", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-6855"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-6855:t:chitin degradation I (archaea)"], "type": "Family"}, "IPR017169": {"description": "Anaphase-promoting complex subunit 4, metazoa", "go_ids": ["GO:0005680", "GO:0031145", "GO:0030071"], "go_terms": ["GO:0005680:anaphase-promoting complex:C", "GO:0031145:anaphase-promoting complex-dependent catabolic process:P", "GO:0030071:regulation of mitotic metaphase/anaphase transition:P"], "name": "APC4_metazoa", "pathway_ids": ["R-HSA-8853884", "R-MMU-176408", "R-MMU-176409", "R-MMU-68867", "R-HSA-174178", "R-HSA-176409", "R-HSA-2467813", "R-HSA-9687136", "R-MMU-174154", "R-MMU-2467813", "R-MMU-179409", "R-MMU-69017", "R-MMU-2559582", "R-HSA-983168", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-MMU-176412", "R-MMU-174048", "R-HSA-176408", "R-MMU-176407", "R-HSA-141430", "R-MMU-174184", "R-MMU-141430", "R-HSA-69017", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-174154", "R-HSA-68867", "R-HSA-176412"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C"], "type": "Family"}, "IPR017170": {"description": "Lhr-like ATP-dependent RNA helicase", "go_ids": ["GO:0005524", "GO:0016818"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F"], "name": "Lhr-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017171": {"description": "Signal transduction histidine kinase, MctS", "go_ids": [], "go_terms": [], "name": "Sig_transdc_His_kinase_MctS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017172": {"description": "Lipopolysaccharide core heptose(I) kinase RfaP", "go_ids": ["GO:0009103", "GO:0016301"], "go_terms": ["GO:0009103:lipopolysaccharide biosynthetic process:P", "GO:0016301:kinase activity:F"], "name": "Lsacc_core_hep_kinase_RfaP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017173": {"description": "Nuclear mRNA export protein Sac3", "go_ids": ["GO:0006406", "GO:0070390"], "go_terms": ["GO:0006406:mRNA export from nucleus:P", "GO:0070390:transcription export complex 2:C"], "name": "Sac3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017174": {"description": "Transcription factor TFIIIB component B'', fungi", "go_ids": ["GO:0000995", "GO:0006383", "GO:0000126"], "go_terms": ["GO:0000995:RNA polymerase III general transcription initiation factor activity:F", "GO:0006383:transcription by RNA polymerase III:P", "GO:0000126:transcription factor TFIIIB complex:C"], "name": "Bdp1_fungi", "pathway_ids": ["R-SCE-76066", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR017175": {"description": "Inhibin, alpha subunit", "go_ids": [], "go_terms": [], "name": "Inhibin_asu", "pathway_ids": ["R-MMU-9839406", "R-SSC-9839406", "R-HSA-9839406", "R-BTA-201451", "R-HSA-201451", "R-BTA-1502540", "R-HSA-1502540", "R-BTA-9839406", "R-SSC-209822", "R-HSA-209822", "R-MMU-209822", "R-SSC-1502540", "R-RNO-209822", "R-MMU-201451", "R-RNO-1502540", "R-RNO-201451", "R-SSC-201451", "R-RNO-9839406", "R-BTA-209822", "R-MMU-1502540"], "pathways": ["R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-SSC-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-BTA-1502540:r:Signaling by Activin", "R-HSA-1502540:r:Signaling by Activin", "R-BTA-9839406:r:TGFBR3 regulates activin signaling", "R-SSC-209822:r:Glycoprotein hormones", "R-HSA-209822:r:Glycoprotein hormones", "R-MMU-209822:r:Glycoprotein hormones", "R-SSC-1502540:r:Signaling by Activin", "R-RNO-209822:r:Glycoprotein hormones", "R-MMU-201451:r:Signaling by BMP", "R-RNO-1502540:r:Signaling by Activin", "R-RNO-201451:r:Signaling by BMP", "R-SSC-201451:r:Signaling by BMP", "R-RNO-9839406:r:TGFBR3 regulates activin signaling", "R-BTA-209822:r:Glycoprotein hormones", "R-MMU-1502540:r:Signaling by Activin"], "type": "Family"}, "IPR017176": {"description": "Alpha-(1, 3)-fucosyltransferase, metazoan", "go_ids": ["GO:0009101", "GO:0000139", "GO:0046920"], "go_terms": ["GO:0009101:glycoprotein biosynthetic process:P", "GO:0000139:Golgi membrane:C", "GO:0046920:alpha-(1->3)-fucosyltransferase activity:F"], "name": "Alpha-1_3-FUT_met", "pathway_ids": ["R-CFA-5173105", "R-DRE-5173105", "R-MMU-5173105", "R-HSA-5173105", "R-RNO-5173105"], "pathways": ["R-CFA-5173105:r:O-linked glycosylation", "R-DRE-5173105:r:O-linked glycosylation", "R-MMU-5173105:r:O-linked glycosylation", "R-HSA-5173105:r:O-linked glycosylation", "R-RNO-5173105:r:O-linked glycosylation"], "type": "Family"}, "IPR017177": {"description": "Alpha-(1, 3)-fucosyltransferase/alpha-(1, 4)-fucosyltransferase, plant", "go_ids": [], "go_terms": [], "name": "Alpha-1_3/4-FUT_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017178": {"description": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, atypical", "go_ids": ["GO:0005506", "GO:0008299", "GO:0046429"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0008299:isoprenoid biosynthetic process:P", "GO:0046429:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin):F"], "name": "IspG_atypical", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017180": {"description": "Phosphotransferase system component IIBC, sugar-specific, predicted", "go_ids": [], "go_terms": [], "name": "PTS_IIBC_sugar_specific", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017181": {"description": "Signal transduction histidine kinase, CHASE2 sensor domain-containing, predicted", "go_ids": [], "go_terms": [], "name": "Sig_transdc_His_kin_CHASE2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017182": {"description": "Methyltransferase METTL16/PsiM", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "METTL16/PsiM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017183": {"description": "Sigma54-dependent transcriptional activator, RtcR", "go_ids": ["GO:0006355", "GO:0003700"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "Sigma54_dep_tscrpt_act_RtcR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017184": {"description": "Serine/threonine-protein kinase Unc-51", "go_ids": ["GO:0004672", "GO:0010506"], "go_terms": ["GO:0004672:protein kinase activity:F", "GO:0010506:regulation of autophagy:P"], "name": "Ser/Thr_kinase_Unc51", "pathway_ids": ["R-CEL-8934903", "R-CEL-1632852", "R-CEL-8854214"], "pathways": ["R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-CEL-1632852:r:Macroautophagy", "R-CEL-8854214:r:TBC/RABGAPs"], "type": "Family"}, "IPR017185": {"description": "Uncharacterised conserved protein UCP037373", "go_ids": [], "go_terms": [], "name": "UCP037373", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017186": {"description": "Lipase, autotransporter EstA", "go_ids": [], "go_terms": [], "name": "Lipase_autotranspt_EstA", "pathway_ids": ["PWY-8454", "PWY-6857", "PWY-6303"], "pathways": ["PWY-8454:t:aspartame degradation", "PWY-6857:t:retinol biosynthesis", "PWY-6303:t:methyl indole-3-acetate interconversion"], "type": "Family"}, "IPR017187": {"description": "Ethylene-insensitive protein 2", "go_ids": ["GO:0009873"], "go_terms": ["GO:0009873:ethylene-activated signaling pathway:P"], "name": "EIN2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017189": {"description": "CTP:phosphocholine cytidylyltransferase", "go_ids": [], "go_terms": [], "name": "CTP-phospocholine_CTT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017190": {"description": "Bifunctional CTP:phosphocholine cytidylyltransferase/choline kinase", "go_ids": [], "go_terms": [], "name": "Bifunc_CCT/choline_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017191": {"description": "Junctophilin", "go_ids": ["GO:0030314"], "go_terms": ["GO:0030314:junctional membrane complex:C"], "name": "Junctophilin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017192": {"description": "Thiosulphate:quinone oxidoreductase, fused subunit DoxA/ DoxD", "go_ids": [], "go_terms": [], "name": "ThioSO4-Q_OxRdtase_DoxA/D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017194": {"description": "Transforming growth factor-beta receptor, type II", "go_ids": ["GO:0004674", "GO:0038023", "GO:0016020", "GO:0043235", "GO:0046872", "GO:0007178"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0038023:signaling receptor activity:F", "GO:0016020:membrane:C", "GO:0043235:signaling receptor complex:C", "GO:0046872:metal ion binding:F", "GO:0007178:cell surface receptor protein serine/threonine kinase signaling pathway:P"], "name": "Transform_growth_fac-b_typ-2", "pathway_ids": ["R-HSA-3645790", "R-GGA-2173788", "R-MMU-2173789", "R-MMU-9839389", "R-GGA-2173789", "R-HSA-2173791", "R-HSA-3656535", "R-HSA-3304356", "R-MMU-2173791", "R-RNO-2173788", "R-HSA-3656532", "R-GGA-2173791", "R-RNO-2173791", "R-HSA-9839389", "R-GGA-9839389", "R-HSA-5689603", "R-HSA-3642279", "R-RNO-9839389", "R-MMU-2173788", "R-HSA-2173788", "R-RNO-2173789", "R-HSA-2173789"], "pathways": ["R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-GGA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-GGA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-5689603:r:UCH proteinases", "R-HSA-3642279:r:TGFBR2 MSI Frameshift Mutants in Cancer", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs"], "type": "Family"}, "IPR017195": {"description": "ABC-type thiamin-related transport system, permease component 1, predicted", "go_ids": [], "go_terms": [], "name": "ABC_thiamin-permease_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017196": {"description": "ECF transporter, predicted substrate-specific component UCP037395", "go_ids": [], "go_terms": [], "name": "ECF_substrate-spec_UCP037395", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017197": {"description": "Bone morphogenetic protein 3/3B", "go_ids": ["GO:0001649"], "go_terms": ["GO:0001649:osteoblast differentiation:P"], "name": "BMP3/BMP3B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017199": {"description": "Uncharacterised conserved protein UCP037409, membrane transporter, MTH672", "go_ids": [], "go_terms": [], "name": "UCP037409_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017200": {"description": "Coenzyme PQQ synthesis protein E-like", "go_ids": [], "go_terms": [], "name": "PqqE-like", "pathway_ids": ["PWY-6420"], "pathways": ["PWY-6420:t:pyrroloquinoline quinone biosynthesis"], "type": "Family"}, "IPR017201": {"description": "Uncharacterised conserved protein UCP037429", "go_ids": [], "go_terms": [], "name": "UCP037429", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017202": {"description": "Sensor histidine kinase LiaS/VraS", "go_ids": ["GO:0000155", "GO:0000160", "GO:0004673", "GO:0016020"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F", "GO:0016020:membrane:C"], "name": "LiaS/VraS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017203": {"description": "Signal transduction histidine kinase, NreB", "go_ids": ["GO:0000155", "GO:0004673", "GO:0005506", "GO:0005524", "GO:0005737", "GO:0018106"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0004673:protein histidine kinase activity:F", "GO:0005506:iron ion binding:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0018106:peptidyl-histidine phosphorylation:P"], "name": "Sig_transdc_His_kinase_NreB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017204": {"description": "Signal transduction histidine kinase, STH3221, predicted", "go_ids": [], "go_terms": [], "name": "Sig_transdc_His_kin_STH3221", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017205": {"description": "Signal transduction histidine kinase, ChrS", "go_ids": [], "go_terms": [], "name": "Sig_transdc_His_kinase_ChrS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017206": {"description": "Signal transduction histidine kinase, hybrid-type, BC3207, predicted", "go_ids": [], "go_terms": [], "name": "Sig_transdc_His_kin_hyb_BC3207", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017207": {"description": "Mitochondrial translation factor Atp22, Saccharomycetaceae", "go_ids": ["GO:0005743", "GO:0006417", "GO:0045182"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C", "GO:0006417:regulation of translation:P", "GO:0045182:translation regulator activity:F"], "name": "Atp22_saccharomyc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017208": {"description": "Uncharacterised conserved protein UCP037442, alpha/beta hydrolase, RSp0795", "go_ids": [], "go_terms": [], "name": "UCP037442_abhydr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017209": {"description": "Alpha/beta hydrolase, predicted", "go_ids": [], "go_terms": [], "name": "Abhydr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017210": {"description": "Actin patch protein 1", "go_ids": [], "go_terms": [], "name": "APP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017211": {"description": "Uncharacterised conserved protein UCP037465, zinc finger protein, AF1427", "go_ids": [], "go_terms": [], "name": "UCP037465_Znf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017212": {"description": "Clathrin heavy chain linker domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "CLHC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017213": {"description": "Peptidase S54, rhomboid, metazoan", "go_ids": ["GO:0004252", "GO:0016020"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0016020:membrane:C"], "name": "Peptidase_S54_rhomboid_met", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017214": {"description": "Cytochrome b561 and DOMON domain-containing protein", "go_ids": [], "go_terms": [], "name": "UCP037471", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017215": {"description": "5-methyltetrahydrofolate-homocysteine S-methyltransferase, bacterial", "go_ids": [], "go_terms": [], "name": "MetH_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017216": {"description": "Hermansky-Pudlak syndrome 3 protein", "go_ids": [], "go_terms": [], "name": "HPS3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017218": {"description": "BLOC-2 complex, Hps6 subunit", "go_ids": [], "go_terms": [], "name": "BLOC-2_complex_Hps6_subunit", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017219": {"description": "Peptidoglycan GlcNAc deacetylase", "go_ids": [], "go_terms": [], "name": "Peptidoglycan_deacetylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017220": {"description": "Sulphite reductase, assimilatory", "go_ids": [], "go_terms": [], "name": "Sulphite_reductase_assimil", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017221": {"description": "DUF34/NIF3, bacteria", "go_ids": [], "go_terms": [], "name": "DUF34/NIF3_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017222": {"description": "DUF34/NIF3, animal", "go_ids": [], "go_terms": [], "name": "DUF34/NIF3_animal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017223": {"description": "Predicted hydrolase of the HAD superfamily, SPs0319-type", "go_ids": [], "go_terms": [], "name": "HAD_SPs0319-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017224": {"description": "Opine oxidase, subunit A/hydrogen cyanide synthase, subunit B", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Opine_Oxase_asu/HCN_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017225": {"description": "Cell shape-determining protein MreD, predicted", "go_ids": [], "go_terms": [], "name": "Cell_shape_determin_MreD_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017226": {"description": "Betaine-homocysteine S-methyltransferase-like", "go_ids": ["GO:0008168", "GO:0008270"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0008270:zinc ion binding:F"], "name": "BHMT-like", "pathway_ids": ["R-RNO-1614635", "R-HSA-6798163", "R-RNO-6798163", "R-DRE-1614635", "R-DRE-6798163", "R-MMU-6798163", "R-MMU-1614635", "R-HSA-1614635"], "pathways": ["R-RNO-1614635:r:Sulfur amino acid metabolism", "R-HSA-6798163:r:Choline catabolism", "R-RNO-6798163:r:Choline catabolism", "R-DRE-1614635:r:Sulfur amino acid metabolism", "R-DRE-6798163:r:Choline catabolism", "R-MMU-6798163:r:Choline catabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-1614635:r:Sulfur amino acid metabolism"], "type": "Family"}, "IPR017227": {"description": "Nucleoside-triphosphatase, alveolata", "go_ids": ["GO:0005576", "GO:0017111"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0017111:ribonucleoside triphosphate phosphatase activity:F"], "name": "NTPase_alveloata", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Family"}, "IPR017229": {"description": "Multidomain scavenger receptor-like protein PxSR", "go_ids": [], "go_terms": [], "name": "Scavenger_rcpt_PxSR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017230": {"description": "Rab geranylgeranyltransferase complex component A", "go_ids": ["GO:0007264"], "go_terms": ["GO:0007264:small GTPase-mediated signal transduction:P"], "name": "Mrs6", "pathway_ids": ["R-SPO-6803205", "R-SCE-8873719", "R-SCE-6803205", "R-SPO-8876198", "R-SCE-8876198", "R-SPO-8873719"], "pathways": ["R-SPO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-SCE-8873719:r:RAB geranylgeranylation", "R-SCE-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8873719:r:RAB geranylgeranylation"], "type": "Family"}, "IPR017231": {"description": "Small GTPase Tem1/Spg1", "go_ids": [], "go_terms": [], "name": "Small_GTPase_Tem1/Spg1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017232": {"description": "Nitrogen regulation protein NtrY", "go_ids": [], "go_terms": [], "name": "NtrY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017233": {"description": "WD repeat protein 35", "go_ids": [], "go_terms": [], "name": "WDR35", "pathway_ids": ["R-MMU-5620924", "R-RNO-5610787", "R-RNO-5620924", "R-HSA-5620924", "R-HSA-5610787", "R-MMU-5610787"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state"], "type": "Family"}, "IPR017234": {"description": "RNA-directed RNA polymerase, rhabdovirus", "go_ids": ["GO:0006139", "GO:0016740"], "go_terms": ["GO:0006139:nucleobase-containing compound metabolic process:P", "GO:0016740:transferase activity:F"], "name": "RNA-dir_pol_rhabdovirus", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR017235": {"description": "RNA-directed RNA polymerase L, filovirus", "go_ids": ["GO:0006139", "GO:0016740"], "go_terms": ["GO:0006139:nucleobase-containing compound metabolic process:P", "GO:0016740:transferase activity:F"], "name": "RNA-dir_pol_L_filovirus", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR017236": {"description": "Glycine/sarcosine/betaine reductase, component C, beta", "go_ids": [], "go_terms": [], "name": "Gly/sarc/bet/_Rdtase_C_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017237": {"description": "RLMG", "go_ids": ["GO:0005737", "GO:0008990", "GO:0031167"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008990:rRNA (guanine-N2-)-methyltransferase activity:F", "GO:0031167:rRNA methylation:P"], "name": "RLMG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017238": {"description": "Squamosa promoter-binding protein", "go_ids": ["GO:0003677", "GO:0003700", "GO:0009908"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0009908:flower development:P"], "name": "SBP_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017239": {"description": "Mitogen-activated protein (MAP) kinase kinase kinase Ste11, Cryptococcus", "go_ids": [], "go_terms": [], "name": "Ste11_Cryptococcus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017240": {"description": "Mitogen-activated protein (MAP) kinase kinase kinase Ssk2/Ssk22", "go_ids": ["GO:0004709", "GO:0005524", "GO:0051403", "GO:0005737"], "go_terms": ["GO:0004709:MAP kinase kinase kinase activity:F", "GO:0005524:ATP binding:F", "GO:0051403:stress-activated MAPK cascade:P", "GO:0005737:cytoplasm:C"], "name": "MAPKKK_Ssk2/Ssk22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017241": {"description": "Toll-like receptor", "go_ids": ["GO:0004888", "GO:0006955", "GO:0016020", "GO:0002224"], "go_terms": ["GO:0004888:transmembrane signaling receptor activity:F", "GO:0006955:immune response:P", "GO:0016020:membrane:C", "GO:0002224:toll-like receptor signaling pathway:P"], "name": "Toll-like_receptor", "pathway_ids": ["R-HSA-6798695", "R-GGA-433822", "R-HSA-168188", "R-HSA-9705671", "R-HSA-166016", "R-RNO-937072", "R-HSA-9824878", "R-MMU-937072", "R-HSA-168179", "R-MMU-166166", "R-HSA-936964", "R-GGA-451514", "R-RNO-166166", "R-MMU-9707616", "R-RNO-140534", "R-HSA-937041", "R-GGA-517856", "R-HSA-9833110", "R-MMU-975163", "R-HSA-5686938", "R-HSA-168176", "R-RNO-9707616", "R-HSA-937072", "R-HSA-1461957", "R-HSA-9918481", "R-MMU-9824878", "R-MMU-936964", "R-RNO-937041", "R-RNO-5686938", "R-HSA-975871", "R-HSA-166058", "R-MMU-140534", "R-RNO-2562578", "R-BTA-168142", "R-MMU-166016", "R-GGA-1461957", "R-GGA-5686938", "R-MMU-1461957", "R-RNO-975163", "R-HSA-9707616", "R-HSA-168142", "R-MMU-5686938", "R-HSA-166166", "R-HSA-5602680", "R-RNO-936964", "R-GGA-6798695", "R-RNO-9824878", "R-HSA-5603037", "R-HSA-9820960", "R-HSA-2562578", "R-HSA-1236974", "R-HSA-5602498", "R-HSA-140534", "R-HSA-5603041", "R-MMU-6798695", "R-MMU-2562578", "R-RNO-166016", "R-MMU-937041", "R-HSA-9637628", "R-HSA-975163"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-HSA-168188:r:Toll Like Receptor TLR6:TLR2 Cascade", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-451514:r:MyD88:TIRAP-dependent cascade initiated on plasma membrane", "R-RNO-166166:r:MyD88-independent TLR4 cascade", "R-MMU-9707616:r:Heme signaling", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-GGA-517856:r:TLR2 subfamily cascade", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-RNO-9707616:r:Heme 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mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9707616:r:Heme signaling", "R-HSA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Family"}, "IPR017242": {"description": "BLOC-1 complex, pallidin subunit", "go_ids": [], "go_terms": [], "name": "BLOC-1_pallidin", "pathway_ids": ["R-BTA-432722", "R-HSA-432722", "R-RNO-432722", "R-MMU-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR017243": {"description": "Biogenesis of lysosome-related organelles complex 1 subunit 5", "go_ids": ["GO:0031083", "GO:0030133"], "go_terms": ["GO:0031083:BLOC-1 complex:C", "GO:0030133:transport vesicle:C"], "name": "Bloc1s5", "pathway_ids": [], 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"pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017250": {"description": "Histone deacetylase complex subunit SAP18", "go_ids": ["GO:0045892", "GO:0003714"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0003714:transcription corepressor activity:F"], "name": "Hist_deAcase_cplx_SAP18", "pathway_ids": ["R-MMU-3214815", "R-DME-3214815", "R-HSA-72163", "R-HSA-3214815", "R-DME-72163", "R-HSA-9679191", "R-MMU-72163", "R-HSA-427413"], "pathways": ["R-MMU-3214815:r:HDACs deacetylate histones", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-3214815:r:HDACs deacetylate histones", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-427413:r:NoRC negatively regulates rRNA expression"], "type": "Family"}, "IPR017251": {"description": "Apoptotic protease-activating factor 1", "go_ids": ["GO:0043293", "GO:0097190"], "go_terms": ["GO:0043293:apoptosome:C", "GO:0097190:apoptotic signaling pathway:P"], "name": "Apaf-1", "pathway_ids": ["R-HSA-111459", "R-HSA-6798695", "R-DRE-111459", "R-HSA-6803207", "R-HSA-111464", "R-HSA-111458", "R-MMU-111458", "R-DRE-111458", "R-RNO-111459", "R-HSA-8953750", "R-DRE-9627069", "R-MMU-111459", "R-RNO-111458", "R-MMU-9627069", "R-DRE-6798695", "R-RNO-9627069", "R-MMU-6798695", "R-HSA-9627069", "R-HSA-111463", "R-RNO-6798695"], "pathways": ["R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-111458:r:Formation of apoptosome", "R-MMU-111458:r:Formation of apoptosome", "R-DRE-111458:r:Formation of apoptosome", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-111458:r:Formation of apoptosome", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR017252": {"description": "Dynein regulator LIS1", "go_ids": [], "go_terms": [], "name": "Dynein_regulator_LIS1", "pathway_ids": ["R-GGA-380284", "R-DRE-1169091", "R-MMU-2467813", "R-DME-8951664", "R-DRE-8951664", "R-GGA-2565942", "R-HSA-380284", "R-MMU-68877", "R-DRE-2467813", "R-DRE-141444", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", 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Chromatid Cohesion", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-GGA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-68877:r:Mitotic Prometaphase", "R-XTR-8951664:r:Neddylation", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-8951664:r:Neddylation"], "type": "Family"}, "IPR017253": {"description": "Transcription factor SRY", "go_ids": ["GO:0003677", "GO:0003700", "GO:0005634", "GO:0030238"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C", "GO:0030238:male sex determination:P"], "name": "SRY", "pathway_ids": ["R-HSA-3769402", "R-HSA-9690406", "R-CFA-3769402", "R-SSC-3769402"], "pathways": ["R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-CFA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-3769402:r:Deactivation of the beta-catenin transactivating complex"], "type": "Family"}, "IPR017254": {"description": "Lipoprotein, LppL", "go_ids": [], "go_terms": [], "name": "Lipoprotein_LppL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017255": {"description": "Acetyltransferase, GNAT, predicted", "go_ids": [], "go_terms": [], "name": "AcTrfase_GNAT_prd", "pathway_ids": ["PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374"], "pathways": ["PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis"], "type": "Family"}, "IPR017256": {"description": "Methane monooxygenase component D", "go_ids": [], "go_terms": [], "name": "MmoD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017257": {"description": "Spore germination protein GerPD, predicted", "go_ids": [], "go_terms": [], "name": "Spore_germination_GerPD_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017258": {"description": "Chloroquine resistance transporter", "go_ids": ["GO:0042910", "GO:0042908"], "go_terms": ["GO:0042910:xenobiotic transmembrane transporter activity:F", "GO:0042908:xenobiotic transport:P"], "name": "Transprt_Chloroquine", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017259": {"description": "Uncharacterised conserved protein UCP037672", "go_ids": [], "go_terms": [], "name": "UCP037672", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017260": {"description": "Uncharacterised conserved protein UCP037673/Ycf91", "go_ids": [], "go_terms": [], "name": "UCP037673/Ycf91", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017261": {"description": "DNA mismatch repair protein MutS/MSH", "go_ids": ["GO:0006298", "GO:0030983"], "go_terms": ["GO:0006298:mismatch repair:P", "GO:0030983:mismatched DNA binding:F"], "name": "DNA_mismatch_repair_MutS/MSH", "pathway_ids": ["R-HSA-5632968", "R-SPO-5358565", "R-SCE-5358565", "R-SPO-5358606", "R-HSA-5358565", "R-SCE-5358606", "R-DDI-5358565", "R-MMU-5358606", "R-DME-5358565", "R-MMU-5358565", "R-HSA-5632928"], "pathways": ["R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2"], "type": "Family"}, "IPR017262": {"description": "Aegyptin-like", "go_ids": [], "go_terms": [], "name": "Aegyptin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017263": {"description": "Uncharacterised conserved protein UCP037692", "go_ids": [], "go_terms": [], "name": "UCP037692", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017264": {"description": "Small ribosomal subunit protein mS37, fungal-type", "go_ids": ["GO:0003735", "GO:0032543"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0032543:mitochondrial translation:P"], "name": "Ribosomal_mS37_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017265": {"description": "rRNA-processing protein Fyv7, fungi", "go_ids": ["GO:0005730", "GO:0006364"], "go_terms": ["GO:0005730:nucleolus:C", "GO:0006364:rRNA processing:P"], "name": "Fyv7_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017266": {"description": "Cyclin-dependent kinase 2-associated protein 1/2", "go_ids": [], "go_terms": [], "name": "DOC_1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017267": {"description": "Cytochrome c oxidase subunit VIIa-related, mitochondrial", "go_ids": [], "go_terms": [], "name": "Cyt_c_oxidase_su7a-rel_mt", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-MMU-9707564", "R-DRE-611105", "R-HSA-9707564", "R-MMU-611105", "R-MMU-5628897", "R-DRE-9864848", "R-DRE-5628897", "R-MMU-9864848", "R-DRE-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-BTA-5628897", "R-BTA-611105", "R-BTA-9707564"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DRE-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9864848:r:Complex IV assembly", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR017268": {"description": "Tax1-binding protein 3", "go_ids": [], "go_terms": [], "name": "Tax1-binding_p3", "pathway_ids": ["R-HSA-5666185"], "pathways": ["R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins"], "type": "Family"}, "IPR017269": {"description": "Biopolymer transport ExbB-like protein 1", "go_ids": [], "go_terms": [], "name": "Biopolymer_transpt_ExbB-like_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017270": {"description": "Putative MotA/TolQ/ExbB family protein", "go_ids": [], "go_terms": [], "name": "MotA/TolQ/ExbB-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017271": {"description": "Transcription regulator HTH, MJ1545", "go_ids": [], "go_terms": [], "name": "MJ1545", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017273": {"description": "Probable cell wall amidase LytH", "go_ids": ["GO:0005576", "GO:0016811", "GO:0071555"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0016811:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides:F", "GO:0071555:cell wall organization:P"], "name": "LytH", "pathway_ids": ["PWY-7403", "PWY-8229", "PWY-7571", "PWY-7850", "PWY-7430", "PWY-8418", "PWY-7496", "PWY-8453", "PWY-8432", "PWY-8293", "PWY-5846", "PWY-7018", "PWY-5497", "PWY-8431", "PWY-1822", "PWY-7821", "PWY-6409", "PWY-6899", "PWY-7652", "PWY-5784", "PWY-7771", "PWY-8402"], "pathways": ["PWY-7403:t:tetramethylpyrazine degradation", "PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7850:t:taurine biosynthesis II", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-8418:t:S-benzyl-L-cysteine degradation", "PWY-7496:t:linuron degradation", "PWY-8453:t:D-glutamate degradation", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-8293:t:alazopeptin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8431:t:L-mimosine degradation", "PWY-1822:t:indole-3-acetate activation I", "PWY-7821:t:tunicamycin biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-6899:t:base-degraded thiamine salvage", "PWY-7652:t:echinocandin B degradation", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-7771:t:butachlor degradation", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR017274": {"description": "Putative N-acetyltransferase YlbP", "go_ids": [], "go_terms": [], "name": "YlbP", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR017275": {"description": "Transcription factor FapR", "go_ids": ["GO:0003700", "GO:0045892", "GO:0045717"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0045717:negative regulation of fatty acid biosynthetic process:P"], "name": "Transcription_factor_FapR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017276": {"description": "Synthesis of cytochrome c oxidase, Sco1/Sco2", "go_ids": ["GO:0005507", "GO:0005743", "GO:0006878", "GO:0008535", "GO:0016531"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0005743:mitochondrial inner membrane:C", "GO:0006878:intracellular copper ion homeostasis:P", "GO:0008535:respiratory chain complex IV assembly:P", "GO:0016531:copper chaperone activity:F"], "name": "Synth_of_cyt-c-oxidase_Sco1/2", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848", "R-BTA-9864848", "R-HSA-5628897", "R-DRE-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR017277": {"description": "Putative antitoxin VapB45-like", "go_ids": [], "go_terms": [], "name": "VapB45-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017278": {"description": "TIR domain-containing adapter molecule 1", "go_ids": ["GO:0045087"], "go_terms": ["GO:0045087:innate immune response:P"], "name": "TICAM1", "pathway_ids": ["R-MMU-140534", "R-HSA-168164", "R-HSA-5602571", "R-HSA-9013973", "R-HSA-9828211", "R-HSA-5602566", "R-MMU-937072", "R-HSA-9824878", "R-HSA-975163", "R-MMU-166166", "R-HSA-166166", "R-HSA-936964", "R-HSA-1810476", "R-HSA-2562578", "R-HSA-168927", "R-HSA-9014325", "R-HSA-937041", "R-MMU-975163", "R-MMU-2562578", "R-HSA-140534", "R-HSA-937072", "R-MMU-937041", "R-HSA-9013957", "R-MMU-9824878", "R-MMU-936964"], "pathways": ["R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-5602566:r:TICAM1 deficiency - HSE", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "type": "Family"}, "IPR017279": {"description": "Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap", "go_ids": [], "go_terms": [], "name": "Tol-interleuk_rcpt_adapt_Tirap", "pathway_ids": ["R-HSA-1236974", "R-HSA-5603041", "R-HSA-5602498", "R-HSA-166058", "R-MMU-166058"], "pathways": ["R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane"], "type": "Family"}, "IPR017281": {"description": "Myeloid differentiation primary response protein MyD88", "go_ids": ["GO:0002755", "GO:0070976", "GO:0043123"], "go_terms": ["GO:0002755:MyD88-dependent toll-like receptor signaling pathway:P", "GO:0070976:TIR domain binding:F", "GO:0043123:positive regulation of canonical NF-kappaB signal transduction:P"], "name": "Myelin_different_resp_MyD88", "pathway_ids": ["R-GGA-433822", "R-HSA-9020702", "R-HSA-975871", "R-HSA-166058", "R-RNO-9020702", "R-HSA-975138", "R-GGA-573298", "R-MMU-209543", "R-MMU-6811558", "R-HSA-209543", "R-RNO-1257604", "R-MMU-9020702", "R-XTR-3134963", "R-MMU-1257604", "R-RNO-3134963", "R-MMU-3134963", "R-HSA-5602680", "R-XTR-209543", "R-RNO-209543", "R-HSA-975155", "R-HSA-5603037", "R-GGA-451514", "R-HSA-1810476", "R-HSA-6811558", "R-HSA-3134963", "R-DRE-209543", "R-RNO-6811558", "R-MMU-1810476", "R-GGA-977240", "R-XTR-9020702", "R-GGA-451477", "R-HSA-5603041", "R-HSA-1236974", "R-HSA-975110", "R-HSA-5602498", "R-HSA-1257604", "R-RNO-1810476"], "pathways": ["R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-GGA-573298:r:NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-XTR-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-XTR-209543:r:p75NTR recruits signalling complexes", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-GGA-451514:r:MyD88:TIRAP-dependent cascade initiated on plasma membrane", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-GGA-977240:r:MyD88 cascade initiated on plasma membrane", "R-XTR-9020702:r:Interleukin-1 signaling", "R-GGA-451477:r:MyD88-dependent cascade initiated on endosome membrane", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1"], "type": "Family"}, "IPR017282": {"description": "Histone deposition protein Asf1", "go_ids": ["GO:0042393", "GO:0006337", "GO:0006334", "GO:0005634"], "go_terms": ["GO:0042393:histone binding:F", "GO:0006337:nucleosome disassembly:P", "GO:0006334:nucleosome assembly:P", "GO:0005634:nucleus:C"], "name": "Hist_deposition_Asf1", "pathway_ids": ["R-SCE-2559584", "R-CEL-2559584"], "pathways": ["R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Family"}, "IPR017283": {"description": "Protein/nucleic acid deglycase HchA", "go_ids": ["GO:0036524"], "go_terms": ["GO:0036524:protein deglycase activity:F"], "name": "HchA", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-7403", "PWY-8184", "PWY-8229", "PWY-7571", "PWY-7850", "PWY-8337", "PWY-7740", "PWY-7430", "PWY-6948", "PWY-8418", "PWY-7496", "PWY-8453", "PWY-981", "PWY-8432", "PWY-8293", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-5846", "PWY-7931", "PWY-5109", "PWY-7018", "PWY-5497", "PWY-6995", "PWY-8431", "PWY-8042", "PWY-3602", "PWY-1822", "PWY-7738", "PWY-7690", "PWY-7821", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-6409", "PWY-6899", "PWY-7742", "PWY-7652", "PWY-7471", "PWY-6917", "PWY-5784", "PWY-7741", "PWY-7771", "PWY-8402"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7403:t:tetramethylpyrazine degradation", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7850:t:taurine biosynthesis II", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-8418:t:S-benzyl-L-cysteine degradation", "PWY-7496:t:linuron degradation", "PWY-8453:t:D-glutamate degradation", "PWY-981:t:salicylate biosynthesis III", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-8293:t:alazopeptin biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-7018:t:paromomycin biosynthesis", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8431:t:L-mimosine degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-1822:t:indole-3-acetate activation I", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-6899:t:base-degraded thiamine salvage", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7652:t:echinocandin B degradation", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-7741:t:phthiocerol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR017284": {"description": "Tautomerase PptA", "go_ids": ["GO:0005737", "GO:0016862"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0016862:intramolecular oxidoreductase activity, interconverting keto- and enol-groups:F"], "name": "Tautomerase_PptA", "pathway_ids": ["PWY-6550", "PWY-5642"], "pathways": ["PWY-6550:t:carbazole degradation", "PWY-5642:t:2,4-dinitrotoluene degradation"], "type": "Family"}, "IPR017285": {"description": "Cyclin, herpesvirus", "go_ids": [], "go_terms": [], "name": "Cyclin_herpesvir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017287": {"description": "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit", "go_ids": ["GO:0050953"], "go_terms": ["GO:0050953:sensory perception of light stimulus:P"], "name": "Rhodop-sen_GMP-Pdiesterase_dsu", "pathway_ids": ["R-HSA-5624958", "R-MMU-5624958", "R-BTA-5624958", "R-MMU-9648002", "R-CFA-9648002", "R-CFA-5624958", "R-BTA-9648002", "R-HSA-9648002", "R-CEL-9648002", "R-DME-9648002"], "pathways": ["R-HSA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-BTA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-9648002:r:RAS processing", "R-CFA-9648002:r:RAS processing", "R-CFA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-BTA-9648002:r:RAS processing", "R-HSA-9648002:r:RAS processing", "R-CEL-9648002:r:RAS processing", "R-DME-9648002:r:RAS processing"], "type": "Family"}, "IPR017288": {"description": "Bcl-2-like protein 11", "go_ids": [], "go_terms": [], "name": "Bcl-2-like_11", "pathway_ids": ["R-MMU-111453", "R-HSA-193648", "R-HSA-9607240", "R-RNO-111453", "R-HSA-111453", "R-HSA-6802952", "R-MMU-193648", "R-HSA-111446", "R-HSA-9614657", "R-MMU-111446", "R-HSA-8862803", "R-RNO-111446", "R-HSA-8952158", "R-RNO-193648"], "pathways": ["R-MMU-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-MMU-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-RNO-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-RNO-193648:r:NRAGE signals death through JNK"], "type": "Family"}, "IPR017289": {"description": "SH2 protein 1A", "go_ids": ["GO:0005737", "GO:0006968", "GO:0007267"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006968:cellular defense response:P", "GO:0007267:cell-cell signaling:P"], "name": "SH2_prot_1A", "pathway_ids": ["R-HSA-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR017290": {"description": "Ribonuclease H, Bacteroides-type", "go_ids": ["GO:0004523"], "go_terms": ["GO:0004523:RNA-DNA hybrid ribonuclease activity:F"], "name": "RNase_H_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017291": {"description": "Sulfofructosephosphate aldolase, YihT", "go_ids": ["GO:0061595", "GO:1902777"], "go_terms": ["GO:0061595:6-deoxy-6-sulfofructose-1-phosphate aldolase activity:F", "GO:1902777:6-sulfoquinovose(1-) catabolic process:P"], "name": 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{"description": "Peptidase S8A, SAM-P45", "go_ids": [], "go_terms": [], "name": "Peptidase_S8A_SAM-P45", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017297": {"description": "Peptidase S8A, DPH-A", "go_ids": [], "go_terms": [], "name": "Peptidase_S8A_DPH-A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017298": {"description": "Transcriptional regulator Ure2", "go_ids": ["GO:0006808", "GO:0003714"], "go_terms": ["GO:0006808:regulation of nitrogen utilization:P", "GO:0003714:transcription corepressor activity:F"], "name": "Ure2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017299": {"description": "DNA fragmentation factor 45", "go_ids": ["GO:0006309", "GO:0060703"], "go_terms": ["GO:0006309:apoptotic DNA fragmentation:P", "GO:0060703:deoxyribonuclease inhibitor activity:F"], "name": "DFF45", "pathway_ids": ["R-HSA-140342", "R-MMU-140342"], "pathways": ["R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-140342:r:Apoptosis induced DNA 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repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Family"}, "IPR017336": {"description": "Snurportin-1", "go_ids": ["GO:0061015", "GO:0005634", "GO:0005737"], "go_terms": ["GO:0061015:snRNA import into nucleus:P", "GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C"], "name": "Snurportin-1", "pathway_ids": ["R-BTA-191859", "R-RNO-191859", "R-HSA-191859", "R-MMU-191859", "R-GGA-191859"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-RNO-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly", "R-MMU-191859:r:snRNP Assembly", "R-GGA-191859:r:snRNP Assembly"], "type": "Family"}, "IPR017337": {"description": "Zinc finger Ran-binding domain-containing protein 2", "go_ids": ["GO:0006396"], "go_terms": ["GO:0006396:RNA processing:P"], "name": "ZRANB2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017339": {"description": "Lytic switch protein BZLF1, human herpesvirus 4", "go_ids": [], "go_terms": [], "name": "BZLF1_HHV-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017340": {"description": "U1 small nuclear ribonucleoprotein C", "go_ids": ["GO:0005685", "GO:0000395", "GO:0030627", "GO:0000398"], "go_terms": ["GO:0005685:U1 snRNP:C", "GO:0000395:mRNA 5'-splice site recognition:P", "GO:0030627:pre-mRNA 5'-splice site binding:F", "GO:0000398:mRNA splicing, via spliceosome:P"], "name": "U1_snRNP-C", "pathway_ids": ["R-DME-9770562", "R-HSA-72163", "R-SPO-9770562", "R-CFA-9770562", "R-HSA-9770562", "R-DRE-9770562", "R-CEL-9770562", "R-MMU-9770562", "R-MMU-72163", "R-RNO-9770562", "R-BTA-9770562", "R-DDI-9770562", "R-BTA-72163"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-CFA-9770562:r:mRNA Polyadenylation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DRE-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-DDI-9770562:r:mRNA Polyadenylation", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR017341": {"description": "Membrane cofactor protein CD46", "go_ids": ["GO:0009986"], "go_terms": ["GO:0009986:cell surface:C"], "name": "CD46", "pathway_ids": ["R-HSA-977606", "R-MMU-977606", "R-RNO-977606"], "pathways": ["R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-977606:r:Regulation of Complement cascade"], "type": "Family"}, "IPR017342": {"description": "S-adenosyl-L-methionine dependent methionine synthase, predicted", "go_ids": [], "go_terms": [], "name": "S-AdoMet-dep_Met_synth_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017343": {"description": "Uncharacterised conserved protein UCP037987", "go_ids": [], "go_terms": [], "name": "UCP037987", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017344": {"description": "Uncharacterised conserved protein UCP037988,TerD, trypsin", "go_ids": [], "go_terms": [], "name": "UCP037988", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017345": {"description": "Peptidase S1A, Tysnd1", "go_ids": [], "go_terms": [], "name": "Pept_S1A_Tysnd1", "pathway_ids": ["R-MMU-9033500", "R-HSA-9033241", "R-HSA-9033500", "R-MMU-9033241"], "pathways": ["R-MMU-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-MMU-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR017346": {"description": "UBX domain-containing protein 2/7", "go_ids": [], "go_terms": [], "name": "UBX_7/2", "pathway_ids": ["R-MMU-8951664", "R-SPO-8951664", "R-HSA-9755511", "R-MMU-9755511", "R-DDI-9755511", "R-SPO-9755511", "R-HSA-8951664", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation"], "type": "Family"}, "IPR017347": {"description": "Heterogeneous nuclear ribonucleoprotein C", "go_ids": [], "go_terms": [], "name": "hnRNP_C", "pathway_ids": ["R-HSA-72203", "R-HSA-9013422", "R-HSA-9013418", "R-HSA-9770562", "R-RNO-9013422", "R-RNO-72203", "R-MMU-72203", "R-MMU-9770562", "R-MMU-72163", "R-MMU-4570464", "R-RNO-72163", "R-HSA-72163", "R-MMU-9013422", "R-RNO-4570464", "R-RNO-9770562", "R-HSA-4570464", "R-MMU-9013418", "R-HSA-9918481", "R-RNO-9013418"], "pathways": ["R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-9013418:r:RHOBTB2 GTPase cycle"], "type": "Family"}, "IPR017348": {"description": "Serine/threonine-protein kinase pim-1/2/3", "go_ids": ["GO:0004674", "GO:0043066", "GO:0006468"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0043066:negative regulation of apoptotic process:P", "GO:0006468:protein phosphorylation:P"], "name": "PIM1/2/3", "pathway_ids": ["R-HSA-9703465", "R-BTA-9968551", "R-HSA-6785807", "R-RNO-9968551", "R-HSA-9702518", "R-HSA-9968551"], "pathways": ["R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-9968551:r:Regulation of GBP-mediated host defense"], "type": "Family"}, "IPR017349": {"description": "Tumour necrosis factor receptor 3", "go_ids": ["GO:0006955", "GO:0043123", "GO:0048534"], "go_terms": ["GO:0006955:immune response:P", "GO:0043123:positive regulation of canonical NF-kappaB signal transduction:P", "GO:0048534:hematopoietic or lymphoid organ development:P"], "name": "TNFR_3_LTBR", "pathway_ids": ["R-HSA-5668541", "R-MMU-5668541", "R-MMU-5676594", "R-HSA-5676594"], "pathways": ["R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "type": "Family"}, "IPR017351": {"description": "LIM and senescent cell antigen-like-containing domain protein 1-4-like", "go_ids": [], "go_terms": [], "name": "PINCH-1-4-like", "pathway_ids": ["R-CEL-446388", "R-DDI-8849471", "R-HSA-446388", "R-BTA-446353", "R-MMU-446353", "R-MMU-446388", "R-HSA-446353", "R-CEL-446353"], "pathways": ["R-CEL-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-446353:r:Cell-extracellular matrix interactions", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-CEL-446353:r:Cell-extracellular matrix interactions"], "type": "Family"}, "IPR017352": {"description": "Methyl-CpG-binding domain protein 4", "go_ids": ["GO:0003677", "GO:0008263", "GO:0006281"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0008263:pyrimidine-specific mismatch base pair DNA N-glycosylase activity:F", "GO:0006281:DNA repair:P"], "name": "MBD4", "pathway_ids": ["R-HSA-110328", "R-MMU-110329", "R-HSA-110357", "R-MMU-110357", "R-HSA-110329"], "pathways": ["R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-110329:r:Cleavage of the damaged pyrimidine"], "type": "Family"}, "IPR017353": {"description": "Methyl-CpG binding protein MeCP2", "go_ids": ["GO:0010385", "GO:0000122", "GO:0005634"], "go_terms": ["GO:0010385:double-stranded methylated DNA binding:F", "GO:0000122:negative regulation of transcription by RNA polymerase II:P", "GO:0005634:nucleus:C"], "name": "Me_CpG-bd_MeCP2", "pathway_ids": ["R-HSA-9022702", "R-HSA-9725371", "R-HSA-9022927", "R-HSA-9022535", "R-HSA-9022692", "R-RNO-9022692", "R-MMU-9022692", "R-HSA-9022537", "R-HSA-9022699", "R-HSA-9022538", "R-HSA-9022534", "R-HSA-8986944", "R-HSA-9022707"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9022927:r:MECP2 regulates transcription of genes involved in GABA signaling", "R-HSA-9022535:r:Loss of phosphorylation of MECP2 at T308", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-RNO-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9022537:r:Loss of MECP2 binding ability to the NCoR/SMRT complex", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-9022538:r:Loss of MECP2 binding ability to 5mC-DNA", "R-HSA-9022534:r:Loss of MECP2 binding ability to 5hmC-DNA", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-9022707:r:MECP2 regulates transcription factors"], "type": "Family"}, "IPR017354": {"description": "Vasodilator-stimulated phosphoprotein/ENA/VASP-like", "go_ids": ["GO:0005856", "GO:0003779", "GO:0008154", "GO:0017124", "GO:0051289"], "go_terms": ["GO:0005856:cytoskeleton:C", "GO:0003779:actin binding:F", "GO:0008154:actin polymerization or depolymerization:P", "GO:0017124:SH3 domain binding:F", "GO:0051289:protein homotetramerization:P"], "name": "VASP/EVL", "pathway_ids": ["R-MMU-446353", "R-MMU-376176", "R-HSA-446353", "R-HSA-202433", "R-DDI-5658442", "R-HSA-376176", "R-HSA-5663220", "R-DDI-446353", "R-RNO-5663220", "R-MMU-5663220"], "pathways": ["R-MMU-446353:r:Cell-extracellular matrix interactions", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-HSA-202433:r:Generation of second messenger molecules", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DDI-446353:r:Cell-extracellular matrix interactions", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR017355": {"description": "Tumour necrosis factor ligand 10/11", "go_ids": [], "go_terms": [], "name": "TNF_ligand_10/11", "pathway_ids": ["R-MMU-9856649", "R-MMU-5676594", "R-HSA-5218900", "R-RNO-5668541", "R-RNO-9856649", "R-HSA-5676594", "R-HSA-5669034", "R-HSA-75158", "R-HSA-69416", "R-HSA-5213460", "R-HSA-5668541", "R-MMU-69416", "R-MMU-5668541", "R-MMU-3371378", "R-MMU-5218900", "R-HSA-9856649", "R-HSA-140534", "R-MMU-5669034", "R-HSA-3371378", "R-MMU-75158", "R-RNO-5676594", "R-RNO-5669034"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-HSA-75158:r:TRAIL signaling", "R-HSA-69416:r:Dimerization of procaspase-8", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-69416:r:Dimerization of procaspase-8", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-3371378:r:Regulation by c-FLIP", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-HSA-3371378:r:Regulation by c-FLIP", "R-MMU-75158:r:TRAIL signaling", "R-RNO-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-RNO-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR017356": {"description": "Chimaerin", "go_ids": ["GO:0005096", "GO:0051056"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0051056:regulation of small GTPase mediated signal transduction:P"], "name": "CHN1/CHN2", "pathway_ids": ["R-HSA-9013149", "R-HSA-9013148", "R-MMU-9013148", "R-MMU-9013149"], "pathways": ["R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Family"}, "IPR017357": {"description": "Telomeric repeat-binding factor 1/2", "go_ids": ["GO:0005634", "GO:0000723", "GO:0042162", "GO:0000781"], "go_terms": ["GO:0005634:nucleus:C", "GO:0000723:telomere maintenance:P", "GO:0042162:telomeric repeat DNA binding:F", "GO:0000781:chromosome, telomeric region:C"], "name": "TERF1/2", "pathway_ids": ["R-MMU-174430", "R-HSA-174414", "R-MMU-174417", "R-HSA-1221632", "R-MMU-110331", "R-MMU-9670095", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-MMU-110330", "R-HSA-171306", "R-MMU-2559586", "R-HSA-174430", "R-HSA-110328", "R-HSA-174411", "R-MMU-171319", "R-HSA-9670095", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Family"}, "IPR017358": {"description": "Ras-related small G protein, RGK family", "go_ids": ["GO:1901842"], "go_terms": ["GO:1901842:negative regulation of high voltage-gated calcium channel activity:P"], "name": "RGK", "pathway_ids": ["R-HSA-9031628", "R-HSA-9768919"], "pathways": ["R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Family"}, "IPR017359": {"description": "Phomoidride biosynthesis cluster protein F-like", "go_ids": [], "go_terms": [], "name": "Phi-like", "pathway_ids": ["R-MMU-3065678"], "pathways": ["R-MMU-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "type": "Family"}, "IPR017360": {"description": "Anthrax toxin receptor", "go_ids": ["GO:0016020", "GO:0038023"], "go_terms": ["GO:0016020:membrane:C", "GO:0038023:signaling receptor activity:F"], "name": "Anthrax_toxin_rcpt", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Family"}, "IPR017361": {"description": "Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN", "go_ids": ["GO:0016314", "GO:0046856", "GO:0051800", "GO:0008285", "GO:0051717"], "go_terms": ["GO:0016314:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity:F", "GO:0046856:phosphatidylinositol dephosphorylation:P", "GO:0051800:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity:F", "GO:0008285:negative regulation of cell population proliferation:P", "GO:0051717:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity:F"], "name": "Bifunc_PIno_P3_Pase/Pase_PTEN", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664", "R-CFA-8948747", "R-RNO-8948751", "R-CFA-1855204", "R-HSA-8948747", "R-CFA-8948751", "R-HSA-5689896", "R-HSA-5689880", "R-HSA-8943723", "R-CFA-1660499", "R-CFA-202424", "R-MMU-8948747", "R-MMU-8948751", "R-MMU-5689896", "R-HSA-1660499", "R-HSA-5628897", "R-CFA-5689896", "R-MMU-1660499", "R-RNO-5689880", "R-CFA-5689880", "R-MMU-5689880", "R-HSA-5674404", "R-RNO-1660499", "R-CFA-199418", "R-HSA-199418", "R-RNO-202424", "R-HSA-1855204", "R-RNO-1855204", "R-HSA-8948751", "R-HSA-8986944", "R-MMU-199418", "R-RNO-5689896", "R-MMU-1855204", "R-HSA-202424", "R-MMU-202424", "R-RNO-8948747", "R-RNO-199418"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "R-CFA-8948747:r:Regulation of PTEN localization", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-CFA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-8948747:r:Regulation of PTEN localization", "R-CFA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CFA-202424:r:Downstream TCR signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CFA-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5674404:r:PTEN Loss of Function in Cancer", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CFA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-8948747:r:Regulation of PTEN localization", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network"], "type": "Family"}, "IPR017362": {"description": "DNA-binding, RFXANK", "go_ids": [], "go_terms": [], "name": "DNA-bd_RFXANK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017363": {"description": "Cdc42 effector protein 2", "go_ids": [], "go_terms": [], "name": "Cdc42_effector_prot_2", "pathway_ids": ["R-BTA-9013406", "R-HSA-9013406", "R-RNO-9013406", "R-RNO-5687128", "R-HSA-5687128", "R-MMU-5687128", "R-MMU-9013406", "R-HSA-9013148"], "pathways": ["R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle"], "type": "Family"}, "IPR017364": {"description": "Gem-associated protein 2", "go_ids": ["GO:0000245", "GO:0005681", "GO:0000387"], "go_terms": ["GO:0000245:spliceosomal complex assembly:P", "GO:0005681:spliceosomal complex:C", "GO:0000387:spliceosomal snRNP assembly:P"], "name": "GEMIN2", "pathway_ids": ["R-HSA-9754678", "R-MMU-191859", "R-RNO-191859", "R-HSA-191859"], "pathways": ["R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-MMU-191859:r:snRNP Assembly", "R-RNO-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly"], "type": "Family"}, "IPR017365": {"description": "Protein lin-7", "go_ids": [], "go_terms": [], "name": "LIN7", "pathway_ids": ["R-HSA-9609736", "R-RNO-212676", "R-BTA-5666185", "R-RNO-5666185", "R-BTA-212676", "R-MMU-212676", "R-HSA-5666185", "R-HSA-212676", "R-HSA-6794361", "R-MMU-5666185"], "pathways": ["R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-6794361:r:Neurexins and neuroligins", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins"], "type": "Family"}, "IPR017366": {"description": "Lysine-specific histone demethylase", "go_ids": ["GO:0005634", "GO:0006355", "GO:0050660"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "Hist_Lys-spec_deMease", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-CEL-983231", "R-DME-9018519", "R-DME-5625886", "R-HSA-3214842", "R-HSA-983231", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9764725", "R-HSA-9679191", "R-MMU-983231", "R-RNO-9018519", "R-MMU-9764725", "R-HSA-5625886", "R-MMU-9018519", "R-RNO-3214815", "R-DME-3214815", "R-RNO-3214842", "R-RNO-9764725", "R-RNO-983231", "R-RNO-5625886", "R-MMU-3214842", "R-CEL-9764725", "R-HSA-8943724", "R-DME-9764725", "R-DME-983231", "R-CEL-3214842", "R-HSA-9029569", "R-HSA-9018519"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-RNO-3214815:r:HDACs deacetylate histones", "R-DME-3214815:r:HDACs deacetylate histones", "R-RNO-3214842:r:HDMs demethylate histones", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-3214842:r:HDMs demethylate histones", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-3214842:r:HDMs demethylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Family"}, "IPR017367": {"description": "Peptidase M12A, nematode astacin 7/8, Caenorhabditis", "go_ids": [], "go_terms": [], "name": "Caenorhab_nas-7/8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017368": {"description": "Peptidase M12A, nematode astacin 9/10/11", "go_ids": ["GO:0004222", "GO:0008270"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Peptidase_M12A_astacin-9/10/11", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR017369": {"description": "SPAN protein/blastula protease 10", "go_ids": [], "go_terms": [], "name": "SPAN/blastula_protease_10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017370": {"description": "Hatching enzyme, Uvs2-like", "go_ids": [], "go_terms": [], "name": "Hatching_enzyme_Uvs2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017371": {"description": "Tumour necrosis factor receptor 11B", "go_ids": [], "go_terms": [], "name": "TNFR_11B", "pathway_ids": ["R-RNO-5669034", "R-HSA-5669034", "R-MMU-5669034", "R-BTA-5669034"], "pathways": ["R-RNO-5669034:r:TNFs bind their physiological receptors", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-BTA-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR017372": {"description": "Glial cell line-derived neurotrophic factor receptor, alpha 1/2", "go_ids": [], "go_terms": [], "name": "Glial_neurotroph_fac_rcpt_a1/2", "pathway_ids": ["R-HSA-9830674", "R-HSA-8853659", "R-RNO-8853659", "R-MMU-8853659", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-419037", "R-HSA-5673001"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8853659:r:RET signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Family"}, "IPR017373": {"description": "Sodium-dependent phosphate transport protein 4 , predicted", "go_ids": [], "go_terms": [], "name": "Na-dep_P-transpt_4_prd", "pathway_ids": ["R-MMU-2672351", "R-HSA-2672351"], "pathways": ["R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR017374": {"description": "Fringe", "go_ids": ["GO:0007389", "GO:0000139", "GO:0033829"], "go_terms": ["GO:0007389:pattern specification process:P", "GO:0000139:Golgi membrane:C", "GO:0033829:O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity:F"], "name": "Fringe", "pathway_ids": ["R-HSA-1912420", "R-HSA-9831926", "R-HSA-5083630", "R-HSA-9824272"], "pathways": ["R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9831926:r:Nephron development", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-9824272:r:Somitogenesis"], "type": "Family"}, "IPR017375": {"description": "Peroxisome assembly protein 12", "go_ids": ["GO:0005778", "GO:0008270", "GO:0005515", "GO:0016558"], "go_terms": ["GO:0005778:peroxisomal membrane:C", "GO:0008270:zinc ion binding:F", "GO:0005515:protein binding:F", "GO:0016558:protein import into peroxisome matrix:P"], "name": "PEX12", "pathway_ids": ["R-MMU-8866654", "R-DME-8866654", "R-BTA-9603798", "R-DME-9033241", "R-SPO-9603798", "R-RNO-9603798", "R-DDI-9603798", "R-MMU-9033241", "R-DME-9603798", "R-RNO-8866654", "R-BTA-9033241", "R-HSA-8866654", "R-RNO-9033241", "R-SCE-9603798", "R-SPO-9033241", "R-BTA-8866654", "R-SCE-9033241", "R-CEL-9603798", "R-MMU-9603798", "R-DDI-9033241", "R-HSA-9603798", "R-HSA-9033241", "R-DDI-8866654"], "pathways": ["R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-DME-9033241:r:Peroxisomal protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-DME-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-9033241:r:Peroxisomal protein import", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-9033241:r:Peroxisomal protein import", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-9033241:r:Peroxisomal protein import", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Family"}, "IPR017376": {"description": "Herpesvirus UL49A", "go_ids": [], "go_terms": [], "name": "Herpes_UL49A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017377": {"description": "Herpesvirus US8A", "go_ids": ["GO:0044196"], "go_terms": ["GO:0044196:host cell nucleolus:C"], "name": "Herpes_US8A", "pathway_ids": [], 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"R-RNO-190373", "R-MMU-190370", "R-MMU-9839389", "R-MMU-190373", "R-MMU-9839397", "R-HSA-190373", "R-RNO-9839389", "R-HSA-190370", "R-RNO-190370", "R-HSA-9839397"], "pathways": ["R-RNO-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-MMU-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-9839397:r:TGFBR3 regulates FGF2 signaling"], "type": "Family"}, "IPR017380": {"description": "Histone acetyltransferase type B, catalytic subunit", "go_ids": ["GO:0004402", "GO:0005634", "GO:0031509"], "go_terms": ["GO:0004402:histone acetyltransferase activity:F", "GO:0005634:nucleus:C", "GO:0031509:subtelomeric heterochromatin formation:P"], "name": "Hist_AcTrfase_B-typ_cat-su", "pathway_ids": ["R-MMU-3214847", "R-SCE-3214847", "R-HSA-3214847", "R-RNO-3214847", "R-SPO-3214847", "R-DDI-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-SCE-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-3214847:r:HATs acetylate histones", "R-SPO-3214847:r:HATs acetylate histones", "R-DDI-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR017381": {"description": "Leukocyte cell-derived chemotaxin 2, chordata", "go_ids": [], "go_terms": [], "name": "LECT2_chordata", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017383": {"description": "Actin-related protein 2/3 complex subunit 1", "go_ids": ["GO:0015629", "GO:0005885", "GO:0034314"], "go_terms": ["GO:0015629:actin cytoskeleton:C", "GO:0005885:Arp2/3 protein complex:C", 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{"description": "Chromatin-remodeling complex component Sfh1/SNF5", "go_ids": ["GO:0006338"], "go_terms": ["GO:0006338:chromatin remodeling:P"], "name": "Sfh1/SNF5", "pathway_ids": ["R-GGA-8939243", "R-GGA-9933939", "R-MMU-9933946", "R-MMU-9934037", "R-XTR-3214858", "R-MMU-9933937", "R-HSA-9933939", "R-GGA-3214858", "R-XTR-8939243", "R-DRE-8939243", "R-BTA-9933946", "R-HSA-3214858", "R-HSA-9824585", "R-BTA-9933937", "R-HSA-9934037", "R-XTR-9933937", "R-BTA-9934037", "R-BTA-3214858", "R-XTR-9934037", "R-MMU-9933939", "R-MMU-3214858", "R-HSA-8939243", "R-MMU-8939243", "R-HSA-9845323", "R-HSA-9933937", "R-BTA-8939243", "R-BTA-9933939", "R-GGA-9933937", "R-HSA-9933946", "R-GGA-9934037", "R-DRE-3214858", "R-GGA-9933946"], "pathways": ["R-GGA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-GGA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-XTR-3214858:r:RMTs methylate histone arginines", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-GGA-3214858:r:RMTs methylate histone arginines", "R-XTR-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-XTR-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-XTR-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-GGA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-GGA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-GGA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex"], "type": "Family"}, "IPR017394": {"description": "LOB domain-containing protein 18/20", "go_ids": [], "go_terms": [], "name": "LOB_18/20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017395": {"description": "Chlorophyllase-like", "go_ids": [], "go_terms": [], "name": "Chlorophyllase-like", "pathway_ids": ["PWY-5098", "PWY-6927", "PWY-7164"], "pathways": ["PWY-5098:t:chlorophyll a degradation I", "PWY-6927:t:chlorophyll a degradation II", "PWY-7164:t:chlorophyll a degradation III"], "type": "Family"}, "IPR017396": {"description": "WRKY transcription factor, group IIc", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "TF_WRKY_IIc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017399": {"description": "WD repeat protein DCAF11/LEC14B", "go_ids": [], "go_terms": [], "name": "DCAF11/LEC14B", "pathway_ids": ["R-MMU-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-CEL-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-CEL-8951664:r:Neddylation"], "type": "Family"}, "IPR017400": {"description": "Eukaryotic elongation factor 2 kinase", "go_ids": ["GO:0004686", "GO:0005509", "GO:0005516", "GO:0006468"], "go_terms": ["GO:0004686:elongation factor-2 kinase activity:F", "GO:0005509:calcium ion binding:F", "GO:0005516:calmodulin binding:F", "GO:0006468:protein phosphorylation:P"], "name": "eEF-2K", "pathway_ids": ["R-RNO-166208", "R-HSA-166208", "R-MMU-166208", "R-CEL-166208"], "pathways": ["R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-CEL-166208:r:mTORC1-mediated signalling"], "type": "Family"}, "IPR017401": {"description": "Protein phosphatase 1 regulatory subunit 12A/B/C", "go_ids": ["GO:0019208", "GO:0007165"], "go_terms": ["GO:0019208:phosphatase regulator activity:F", "GO:0007165:signal transduction:P"], "name": "MYPT1/MYPT2/Mbs85", "pathway_ids": ["R-GGA-5627123", "R-RNO-5627123", "R-HSA-5625900", "R-HSA-5627123", "R-RNO-5625740", "R-RNO-2565942", "R-DRE-2565942", "R-DRE-5625740", "R-MMU-5627123", "R-HSA-5625740", "R-MMU-5625740", "R-GGA-2565942", "R-MMU-2565942", "R-HSA-5627117", "R-HSA-2565942"], "pathways": ["R-GGA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR017402": {"description": "Proteorhodopsin", "go_ids": ["GO:0010461", "GO:0016020", "GO:0006811"], "go_terms": ["GO:0010461:light-activated monoatomic ion channel activity:F", "GO:0016020:membrane:C", "GO:0006811:monoatomic ion transport:P"], "name": "Proteorhodopsin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017403": {"description": "Podocalyxin", "go_ids": ["GO:0022407", "GO:0016477"], "go_terms": ["GO:0022407:regulation of cell-cell adhesion:P", "GO:0016477:cell migration:P"], "name": "PODXL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017404": {"description": "Ladinin 1", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Ladinin_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017405": {"description": "Citron Rho-interacting kinase", "go_ids": [], "go_terms": [], "name": "Citron_Rho-interacting_kinase", "pathway_ids": ["R-RNO-9013026", "R-RNO-5625900", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-5625900", "R-MMU-9013106", "R-MMU-9013026", "R-MMU-8980692", "R-MMU-5625900", "R-RNO-8980692", "R-HSA-9013026", "R-RNO-9013149", "R-RNO-9013106", "R-HSA-9013106", "R-MMU-9013149"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Family"}, "IPR017406": {"description": "Serine/threonine-protein kinase Rio3", "go_ids": ["GO:0004674", "GO:0005524", "GO:0006468"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P"], "name": "Ser/Thr_kinase_Rio3", "pathway_ids": ["R-BTA-6791226", "R-HSA-6791226", "R-MMU-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR017407": {"description": "Serine/threonine-protein kinase Rio1", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "Ser/Thr_kinase_Rio1", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-DDI-6791226"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR017408": {"description": "Arginine N-methyltransferase 2", "go_ids": ["GO:0016274"], "go_terms": ["GO:0016274:protein-arginine N-methyltransferase activity:F"], "name": "Arginine_N-MeTrfase_2", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-SPO-71288", "R-SCE-71288"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-SPO-71288:r:Creatine metabolism", "R-SCE-71288:r:Creatine metabolism"], "type": "Family"}, "IPR017409": {"description": "Pyruvate Pi dikinase regulator, chloroplast", "go_ids": ["GO:0004674", "GO:0005524", "GO:0009507", "GO:0016776"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0009507:chloroplast:C", "GO:0016776:phosphotransferase activity, phosphate group as acceptor:F"], "name": "Pyrv_Pi_dikinase_reg_chlpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017410": {"description": "Mitochondrial outer membrane transport complex protein Metaxin 1/3", "go_ids": ["GO:0007005", "GO:0001401"], "go_terms": ["GO:0007005:mitochondrion organization:P", "GO:0001401:SAM complex:C"], "name": "Metaxin1/3", "pathway_ids": ["R-SSC-9013404", 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"R-MMU-196807:r:Nicotinate metabolism", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-9833482:r:PKR-mediated signaling", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-SCE-196807:r:Nicotinate metabolism", "R-SCE-1660661:r:Sphingolipid de novo biosynthesis", "R-SCE-9833482:r:PKR-mediated signaling", "R-DDI-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-SPO-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-SPO-1483206:r:Glycerophospholipid biosynthesis", "R-SCE-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-CEL-1483206:r:Glycerophospholipid biosynthesis", "R-DDI-9833482:r:PKR-mediated signaling", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-DDI-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-196807:r:Nicotinate metabolism", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-9833482:r:PKR-mediated signaling", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-196807:r:Nicotinate metabolism", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-XTR-196807:r:Nicotinate metabolism", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-1483206:r:Glycerophospholipid biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-9833482:r:PKR-mediated signaling", "R-CEL-5218921:r:VEGFR2 mediated cell proliferation", "R-SCE-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-CEL-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-9833482:r:PKR-mediated signaling", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Homologous_superfamily"}, "IPR017439": {"description": "Amidohydrolase", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Amidohydrolase", "pathway_ids": ["PWY-2941"], "pathways": ["PWY-2941:t:L-lysine biosynthesis II"], "type": "Family"}, "IPR017443": {"description": "Ribulose bisphosphate carboxylase, large subunit, ferrodoxin-like N-terminal", "go_ids": ["GO:0015977", "GO:0016984"], "go_terms": ["GO:0015977:carbon fixation:P", "GO:0016984:ribulose-bisphosphate carboxylase activity:F"], "name": "RuBisCO_lsu_fd_N", "pathway_ids": ["PWY-5723", "PWY-5532"], "pathways": ["PWY-5723:t:Rubisco shunt", "PWY-5532:t:nucleoside and nucleotide degradation (archaea)"], "type": "Domain"}, "IPR017449": {"description": "Prolyl-tRNA synthetase, class II", "go_ids": ["GO:0000166", "GO:0004827", "GO:0005524", "GO:0005737", "GO:0006433"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004827:proline-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006433:prolyl-tRNA aminoacylation:P"], "name": "Pro-tRNA_synth_II", "pathway_ids": ["R-MMU-9856649", "R-HSA-9856649", "R-HSA-2408522", "R-HSA-6782315", "R-HSA-379716", "R-DME-9856649"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Homologous_superfamily"}, "IPR017451": {"description": "F-box associated beta-propeller domain", "go_ids": [], "go_terms": [], "name": "F-box-assoc_interact_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017453": {"description": "Glycine cleavage system H-protein, subgroup", "go_ids": ["GO:0005960", "GO:0019464"], "go_terms": ["GO:0005960:glycine cleavage complex:C", "GO:0019464:glycine decarboxylation via glycine cleavage system:P"], "name": "GCV_H_sub", "pathway_ids": ["R-RNO-6783984", "R-SPO-9857492", "R-MMU-6783984", "R-BTA-6783984", "R-MMU-9857492", "R-DME-9857492", "R-HSA-6783984", "R-SCE-6783984", "R-DDI-6783984", "R-RNO-9857492", "R-SCE-9857492", "R-GGA-6783984", "R-GGA-9857492", "R-BTA-9857492", "R-DDI-9857492", "R-SPO-6783984", "R-DME-6783984", "R-HSA-9857492"], "pathways": ["R-RNO-6783984:r:Glycine degradation", "R-SPO-9857492:r:Protein lipoylation", "R-MMU-6783984:r:Glycine degradation", "R-BTA-6783984:r:Glycine degradation", "R-MMU-9857492:r:Protein lipoylation", "R-DME-9857492:r:Protein lipoylation", "R-HSA-6783984:r:Glycine degradation", "R-SCE-6783984:r:Glycine degradation", "R-DDI-6783984:r:Glycine degradation", "R-RNO-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-GGA-6783984:r:Glycine degradation", "R-GGA-9857492:r:Protein lipoylation", "R-BTA-9857492:r:Protein lipoylation", "R-DDI-9857492:r:Protein lipoylation", "R-SPO-6783984:r:Glycine degradation", "R-DME-6783984:r:Glycine degradation", "R-HSA-9857492:r:Protein lipoylation"], "type": "Family"}, "IPR017454": {"description": "Neuromodulin, C-terminal", "go_ids": ["GO:0040008"], "go_terms": ["GO:0040008:regulation of growth:P"], "name": "Neuromodulin_C", "pathway_ids": ["R-RNO-373760", "R-MMU-373760", "R-HSA-373760", "R-BTA-373760"], "pathways": ["R-RNO-373760:r:L1CAM interactions", "R-MMU-373760:r:L1CAM interactions", "R-HSA-373760:r:L1CAM interactions", "R-BTA-373760:r:L1CAM interactions"], "type": "Domain"}, "IPR017456": {"description": "CTP synthase, N-terminal", "go_ids": ["GO:0003883", "GO:0006221"], "go_terms": ["GO:0003883:CTP synthase activity:F", "GO:0006221:pyrimidine nucleotide biosynthetic process:P"], "name": "CTP_synthase_N", "pathway_ids": ["PWY-7176", "PWY-7185", "PWY-7177", "R-DRE-499943", "R-DME-499943", "R-GGA-499943", "R-BTA-499943", "R-MMU-499943", "R-SCE-499943", "R-SPO-499943", "R-HSA-499943", "R-DDI-499943", "R-RNO-499943"], "pathways": ["PWY-7176:t:UTP and CTP de novo biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7177:t:UTP and CTP dephosphorylation II", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-GGA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Domain"}, "IPR017459": {"description": "Glycosyl transferase family 3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Glycosyl_Trfase_fam3_N_dom", "pathway_ids": ["R-RNO-73621", "R-MMU-73614", "R-HSA-73621", "R-HSA-73614", "R-MMU-73621", "R-RNO-73614"], "pathways": ["R-RNO-73621:r:Pyrimidine catabolism", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-73614:r:Pyrimidine salvage"], "type": "Domain"}, "IPR017460": {"description": "Conserved hypothetical domain CHP03000, planctomycetes", "go_ids": [], "go_terms": [], "name": "CHP03000_planctomycetes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017461": {"description": "Conserved hypothetical domain CHP03009, planctomycetes", "go_ids": [], "go_terms": [], "name": "CHP03009_planctomycetes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017462": {"description": "Sulphur relay, TusC/DsrF", "go_ids": [], "go_terms": [], "name": "Sulphur_relay_TusC/DsrF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017463": {"description": "Sulphur relay, TusD/DsrE", "go_ids": ["GO:0005737", "GO:0008033", "GO:0016783"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008033:tRNA processing:P", "GO:0016783:sulfurtransferase activity:F"], "name": "Sulphur_relay_TusD/DsrE", "pathway_ids": ["PWY-7889", "PWY-7888", "PWY-6892", "PWY-5303", "PWY-7904", "PWY-7250", "PWY-7892", "PWY-8164", "PWY-6675", "PWY-8179", "PWY-7891", "PWY-7887"], "pathways": ["PWY-7889:t:tRNA-uridine 2-thiolation (mammalian mitochondria)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6892:t:thiazole component of thiamine diphosphate biosynthesis I", "PWY-5303:t:thiosulfate oxidation II (via tetrathionate)", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-8164:t:bis(guanylyl molybdopterin) cofactor sulfurylation", "PWY-6675:t:sulfur oxidation IV (intracellular sulfur)", "PWY-8179:t:platensimycin biosynthesis", "PWY-7891:t:tRNA-uridine 2-thiolation (yeast mitochondria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation"], "type": "Family"}, "IPR017464": {"description": "Sugar transferase, PEP-CTERM system associated", "go_ids": [], "go_terms": [], "name": "Sugar_tfrase_EpsB_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017465": {"description": "Exopolysaccharide biosynthesis operon, EpsL, proteobacteria", "go_ids": [], "go_terms": [], "name": "EpsL_proteobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017466": {"description": "XrtA-associated ATPase-like", "go_ids": [], "go_terms": [], "name": "XrtA-assoc_ATPase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017467": {"description": "Conserved hypothetical protein CHP03016, PEP-CTERM", "go_ids": [], "go_terms": [], "name": "CHP03016_PEP-CTERM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017468": {"description": "Chain length determinant protein EpsF", "go_ids": [], "go_terms": [], "name": "Chain_len_reg_EpsF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017469": {"description": "PEP-CTERM system-associated, FemAB-related", "go_ids": [], "go_terms": [], "name": "PEP-CTERM_FemAB-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017470": {"description": "Transcription regulator EpsA", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_EpsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017472": {"description": "Undecaprenyl-phosphate galactose phosphotransferase, WbaP", "go_ids": ["GO:0000271", "GO:0005886", "GO:0016020", "GO:0016740"], "go_terms": ["GO:0000271:polysaccharide biosynthetic process:P", "GO:0005886:plasma membrane:C", "GO:0016020:membrane:C", "GO:0016740:transferase activity:F"], "name": "Undecaprenyl-P_galact_Ptfrase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017473": {"description": "Undecaprenyl-phosphate glucose phosphotransferase, WcaJ", "go_ids": [], "go_terms": [], "name": "Undecaprenyl-P_gluc_Ptfrase", "pathway_ids": ["PWY-8460", "PWY-8243", "PWY-6655", "PWY-6658"], "pathways": ["PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-6658:t:acetan biosynthesis"], "type": "Family"}, "IPR017474": {"description": "PEF-CTERM protein sorting domain, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PEF_CTERM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017475": {"description": "Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase", "go_ids": [], "go_terms": [], "name": "EPS_sugar_tfrase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017476": {"description": "UDP-glucose/GDP-mannose dehydrogenase", "go_ids": ["GO:0016616"], "go_terms": ["GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "UDP-Glc/GDP-Man", "pathway_ids": ["PWY-7346", "PWY-7820", "R-BTA-173599", "R-HSA-173599", "R-CEL-173599", "R-RNO-173599", "R-MMU-173599", "R-DME-173599"], "pathways": ["PWY-7346:t:UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "R-BTA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-CEL-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-RNO-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DME-173599:r:Formation of the active cofactor, UDP-glucuronate"], "type": "Family"}, "IPR017477": {"description": "PEP-CTERM, putative polysaccharide export protein", "go_ids": [], "go_terms": [], "name": "PEP-CTERM_polysacc_export", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017478": {"description": "Polysaccharide export EpsE", "go_ids": [], "go_terms": [], "name": "Polysacc_export_EpsE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017479": {"description": "Tyrosine-protein kinase, chain length determinant protein EpsG", "go_ids": [], "go_terms": [], "name": "Tyr_kinase_chain_length_EpsG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017481": {"description": "Conserved hypothetical protein CHP03032", "go_ids": [], "go_terms": [], "name": "CHP03032", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017482": {"description": "Lambda-type exonuclease", "go_ids": [], "go_terms": [], "name": "Lambda-type_endonuclease", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017483": {"description": "Conserved hypothetical protein CHP03034", "go_ids": [], "go_terms": [], "name": "CHP03034", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017484": {"description": "Kynurenine formamidase, bacteria", "go_ids": ["GO:0006569", "GO:0004328"], "go_terms": ["GO:0006569:L-tryptophan catabolic process:P", "GO:0004328:formamidase activity:F"], "name": "Kynurenine_formamidase_bac", "pathway_ids": ["PWY-6309", "PWY-7717", "PWY-7734", "PWY-7765", "PWY-5651", "PWY-7733"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-5651:t:L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde", "PWY-7733:t:3-hydroxyquinaldate biosynthesis"], "type": "Family"}, "IPR017485": {"description": "Tryptophan 2,3-dioxygenase, bacterial", "go_ids": ["GO:0006569", "GO:0004833"], "go_terms": ["GO:0006569:L-tryptophan catabolic process:P", "GO:0004833:L-tryptophan 2,3-dioxygenase activity:F"], "name": "Trp_2-3-dOase_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017486": {"description": "Photosystem II CP47 reaction centre protein", "go_ids": ["GO:0016168", "GO:0009523", "GO:0015979", "GO:0016020", "GO:0009772"], "go_terms": ["GO:0016168:chlorophyll binding:F", "GO:0009523:photosystem II:C", "GO:0015979:photosynthesis:P", "GO:0016020:membrane:C", "GO:0009772:photosynthetic electron transport in photosystem II:P"], "name": "PSII_PsbB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017487": {"description": "Photosystem II PsbQ, cyanobacteria", "go_ids": [], "go_terms": [], "name": "PSII_PsbQ_cyanobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017488": {"description": "Photosystem II Psb27, cyanobacteria", "go_ids": ["GO:0009523", "GO:0010207", "GO:0010206"], "go_terms": ["GO:0009523:photosystem II:C", "GO:0010207:photosystem II assembly:P", "GO:0010206:photosystem II repair:P"], "name": "PSII_Psb27_cyano_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017491": {"description": "Photosystem I protein PsaC", "go_ids": ["GO:0009055", "GO:0009773", "GO:0042651", "GO:0051539", "GO:0015979", "GO:0009522"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0009773:photosynthetic electron transport in photosystem I:P", "GO:0042651:thylakoid membrane:C", "GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0015979:photosynthesis:P", "GO:0009522:photosystem I:C"], "name": "PSI_PsaC", "pathway_ids": ["PWY-101", "PWY-8270"], "pathways": ["PWY-101:t:photosynthesis light reactions", "PWY-8270:t:cyclic electron flow"], "type": "Family"}, "IPR017492": {"description": "Photosystem I reaction center subunit PsaK", "go_ids": ["GO:0042651", "GO:0015979", "GO:0009522"], "go_terms": ["GO:0042651:thylakoid membrane:C", "GO:0015979:photosynthesis:P", "GO:0009522:photosystem I:C"], "name": "PSI_PsaK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017493": {"description": "Photosystem I reaction center subunit psaK, plant", "go_ids": [], "go_terms": [], "name": "PSI_PsaK_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017494": {"description": "Photosystem I reaction center subunit V", "go_ids": ["GO:0009522", "GO:0009535", "GO:0015979"], "go_terms": ["GO:0009522:photosystem I:C", "GO:0009535:chloroplast thylakoid membrane:C", "GO:0015979:photosynthesis:P"], "name": "PSI_PsaG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017495": {"description": "Photosynthetic complex assembly protein PuhC", "go_ids": [], "go_terms": [], "name": "PuhC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017496": {"description": "Photosynthetic complex assembly protein 2, putative", "go_ids": [], "go_terms": [], "name": "Photo_alph_chp2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017497": {"description": "Magnesium-chelatase 30 kDa subunit", "go_ids": [], "go_terms": [], "name": "BchO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017498": {"description": "Photosystem I PsaO", "go_ids": [], "go_terms": [], "name": "PSI_PsaO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017499": {"description": "Protein Thf1", "go_ids": ["GO:0015979", "GO:0010207"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0010207:photosystem II assembly:P"], "name": "Thf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017500": {"description": "Phage infection protein, YhgE, N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_infect_YhgE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017501": {"description": "Phage infection protein, YhgE, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_infect_YhgE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017502": {"description": "Sortase B cell surface sorting signal", "go_ids": [], "go_terms": [], "name": "Sortase_SrtB_target", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017503": {"description": "Sortase B signal domain, QVPTGV class", "go_ids": [], "go_terms": [], "name": "Sortase_SrtB_sig_QVPTGV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017504": {"description": "Conserved hypothetical protein CHP03067, planctomycetes", "go_ids": [], "go_terms": [], "name": "CHP03067_Planctomycetes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017505": {"description": "Sortase B signal domain, NPQTN class", "go_ids": [], "go_terms": [], "name": "Sortase_SrtB_sig_NPQTN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017506": {"description": "Photosystem II S4", "go_ids": [], "go_terms": [], "name": "PSII_S4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017507": {"description": "Transcription regulator, HipB-like", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_HipB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017508": {"description": "HipA, N-terminal subdomain 1", "go_ids": [], "go_terms": [], "name": "HipA_N1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017509": {"description": "Peptide chain release factor homolog", "go_ids": [], "go_terms": [], "name": "PrfH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017510": {"description": "RNA-splicing ligase RtcB2/Anti-repressor ArmZ", "go_ids": [], "go_terms": [], "name": "RtcB2/ArmZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017511": {"description": "PQQ-dependent membrane bound dehydrogenase", "go_ids": ["GO:0016020", "GO:0016614", "GO:0048038"], "go_terms": ["GO:0016020:membrane:C", "GO:0016614:oxidoreductase activity, acting on CH-OH group of donors:F", "GO:0048038:quinone binding:F"], "name": "PQQ_mDH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017512": {"description": "PQQ-dependent dehydrogenase, methanol/ethanol family", "go_ids": ["GO:0005509", "GO:0016020", "GO:0016614"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0016020:membrane:C", "GO:0016614:oxidoreductase activity, acting on CH-OH group of donors:F"], "name": "PQQ_MeOH/EtOH_DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017513": {"description": "Conserved hypothetical protein CHP03076, glycine cleavage", "go_ids": [], "go_terms": [], "name": "CHP03076_Gly-cleavage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017514": {"description": "Glycine cleavage system protein H-related, Chlamydia", "go_ids": [], "go_terms": [], "name": "GcvH_Chlamydia", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017515": {"description": "Methylmalonyl-CoA epimerase", "go_ids": [], "go_terms": [], "name": "MeMalonyl-CoA_epimerase", "pathway_ids": ["PWY-5743", "PWY-8086", "PWY-5789", "PWY-7854", "PWY-7384", "PWY-5741", "PWY-6728", "R-HSA-71032", "R-MMU-71032", "R-DDI-71032"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-5741:t:ethylmalonyl-CoA pathway", "PWY-6728:t:methylaspartate cycle", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-DDI-71032:r:Propionyl-CoA catabolism"], "type": "Family"}, "IPR017516": {"description": "AbrB duplication", "go_ids": [], "go_terms": [], "name": "AbrB_dup", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017517": {"description": "Maleylpyruvate isomerase, mycothiol-dependent enzyme", "go_ids": [], "go_terms": [], "name": "Maleyloyr_isom", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017518": {"description": "Conserved hypothetical protein CHP03084", "go_ids": [], "go_terms": [], "name": "CHP03084", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017519": {"description": "Conserved hypothetical protein CHP03085", "go_ids": [], "go_terms": [], "name": "CHP03085", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017520": {"description": "Conserved hypothetical protein CHP03086", "go_ids": [], "go_terms": [], "name": "CHP03086", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017521": {"description": "Sugar transferase, PEP-CTERM, Stp1", "go_ids": [], "go_terms": [], "name": "Sugar_tfrase_PEP-CTERM_Stp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017522": {"description": "Sugar transferase, PEP-CTERM, Stp2", "go_ids": [], "go_terms": [], "name": "Sugar_tfrase_PEP-CTERM_Stp2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017523": {"description": "Rv3268-like", "go_ids": [], "go_terms": [], "name": "Rv3268", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017524": {"description": "Small acid-soluble spore protein, thioredoxin-like", "go_ids": [], "go_terms": [], "name": "SASP_thioredoxin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017525": {"description": "Small, acid-soluble spore protein I", "go_ids": ["GO:0030436"], "go_terms": ["GO:0030436:asexual sporulation:P"], "name": "SspI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017526": {"description": "Small acid-soluble spore protein, SspL", "go_ids": [], "go_terms": [], "name": "SASP_SspL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017527": {"description": "Nitrosocyanin", "go_ids": [], "go_terms": [], "name": "Nitrosocyanin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017528": {"description": "Conserved hypothetical protein CHP03097, O-antigen ligase-related", "go_ids": [], "go_terms": [], "name": "CHP03097O-antigen_lig-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017529": {"description": "Acyl-CoA ligase (AMP-forming), exosortase system type 1 associated", "go_ids": [], "go_terms": [], "name": "AcylCoA_ligase_PEP_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017530": {"description": "Pyridoxal-dependent decarboxylase, exosortase system type 1 associated", "go_ids": [], "go_terms": [], "name": "DCO2ase_PEP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017531": {"description": "Hydrolase, ortholog 1, exosortase system type 1 associated", "go_ids": [], "go_terms": [], "name": "Hydrolase-1_PEP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017532": {"description": "Hydrolase, ortholog 2, exosortase system type 1 associated", "go_ids": [], "go_terms": [], "name": "Hydrolase-2_PEP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017533": {"description": "Halocyanin, copper-binding domain", "go_ids": [], "go_terms": [], "name": "Halocyanin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017534": {"description": "GNAT-acetyltransferase", "go_ids": [], "go_terms": [], "name": "GNAT-acetyltransferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017535": {"description": "Asparagine synthase family amidotransferase", "go_ids": [], "go_terms": [], "name": "Asparagine_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017536": {"description": "Glutamine synthetase, type III", "go_ids": [], "go_terms": [], "name": "Glutamine_synthetase_typeIII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017537": {"description": "Peptidase M42, hydrolase", "go_ids": [], "go_terms": [], "name": "Peptidase_M42_hydrolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017538": {"description": "Peptidase M42, glutamyl aminopeptidase", "go_ids": [], "go_terms": [], "name": "Pept_M42_glutamyl_aminopept", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017539": {"description": "XrtA/PEP-CTERM system amidotransferase", "go_ids": [], "go_terms": [], "name": "XrtA_amidotfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017540": {"description": "Exosortase 1", "go_ids": [], "go_terms": [], "name": "Exosortase-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017541": {"description": "Exosortase family protein XrtG", "go_ids": [], "go_terms": [], "name": "Exosort-XrtG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017542": {"description": "XrtG-associated glycosyltransferase", "go_ids": [], "go_terms": [], "name": "XrtG-assoc_glycosyltfrase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017543": {"description": "6-pyruvoyl tetrahydropterin synthase-related, bacteria", "go_ids": [], "go_terms": [], "name": "6-PTP_synth-rel_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017544": {"description": "Exosortase 2", "go_ids": [], "go_terms": [], "name": "Exosortase-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017545": {"description": "CRISPR-associated protein Csf1", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017546": {"description": "CRISPR type IV/AFERR-associated protein Csf2", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csf2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017547": {"description": "CRISPR type IV-associated protein Csf3, proteobacteria", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Csf3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017548": {"description": "CRISPR-associated DEAD/DEAH-box helicase Csf4", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_helicase_Csf4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017549": {"description": "Acanthamoeba polyphaga mimivirus, L690", "go_ids": [], "go_terms": [], "name": "APMV_L690", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017550": {"description": "Formylmethanofuran dehydrogenase subunit C", "go_ids": ["GO:0015948", "GO:0018493", "GO:0046914"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0018493:formylmethanofuran dehydrogenase activity:F", "GO:0046914:transition metal ion binding:F"], "name": "Formylmethanofuran_DH_suC", "pathway_ids": ["PWY-5209", "PWY-7784", "PWY-8305"], "pathways": ["PWY-5209:t:methyl-coenzyme M oxidation to CO2 I", "PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)", "PWY-8305:t:methoxylated aromatic compound degradation II"], "type": "Domain"}, "IPR017551": {"description": "Triphosphoribosyl-dephospho-CoA synthase CitG", "go_ids": ["GO:0016310", "GO:0046917", "GO:0005524"], "go_terms": ["GO:0016310:phosphorylation:P", "GO:0046917:triphosphoribosyl-dephospho-CoA synthase activity:F", "GO:0005524:ATP binding:F"], "name": "TriPribosyl-deP-CoA_syn_CitG", "pathway_ids": ["PWY-5796"], "pathways": ["PWY-5796:t:malonate decarboxylase activation"], "type": "Family"}, "IPR017552": {"description": "3-hexulose-6-phosphate isomerase", "go_ids": ["GO:0016853"], "go_terms": ["GO:0016853:isomerase activity:F"], "name": "PHI/rmpB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017553": {"description": "3-hexulose-6-phosphate synthase", "go_ids": ["GO:0005975", "GO:0043801"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0043801:hexulose-6-phosphate synthase activity:F"], "name": "3-hexulose-6-phosphate_synth", "pathway_ids": ["PWY-1861", "PWY-7796"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-7796:t:pentose phosphate pathway (oxidative branch) II"], "type": "Domain"}, "IPR017554": {"description": "Malonate decarboxylase, McdH subunit", "go_ids": [], "go_terms": [], "name": "Malonate_deCOase_MdcHsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017555": {"description": "Triphosphoribosyl-dephospho-CoA synthase", "go_ids": ["GO:0046917", "GO:0005524", "GO:0016310"], "go_terms": ["GO:0046917:triphosphoribosyl-dephospho-CoA synthase activity:F", "GO:0005524:ATP binding:F", "GO:0016310:phosphorylation:P"], "name": "TriPribosyl-deP-CoA_syn", "pathway_ids": ["PWY-5796"], "pathways": ["PWY-5796:t:malonate decarboxylase activation"], "type": "Family"}, "IPR017556": {"description": "Biotin-independent malonate decarboxylase, beta subunit", "go_ids": ["GO:0005975", "GO:0016831"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016831:carboxy-lyase activity:F"], "name": "Malonate_beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017557": {"description": "Phosphoribosyl-dephospho-CoA transferase", "go_ids": ["GO:0016779"], "go_terms": ["GO:0016779:nucleotidyltransferase activity:F"], "name": "Holo-ACP_synthase", "pathway_ids": ["PWY-5796"], "pathways": ["PWY-5796:t:malonate decarboxylase activation"], "type": "Family"}, "IPR017558": {"description": "Malonate decarboxylase, carboxybiotin decarboxylase subunit, Na+ transporting", "go_ids": [], "go_terms": [], "name": "Malonate_biotin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017559": {"description": "Alkyl hydroperoxide reductase subunit C", "go_ids": ["GO:0006979", "GO:0051920"], "go_terms": ["GO:0006979:response to oxidative stress:P", "GO:0051920:peroxiredoxin activity:F"], "name": "AhpC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017560": {"description": "Cytochrome c-type biogenesis protein CcmI", "go_ids": [], "go_terms": [], "name": "Cyt_c_biogenesis_CcmI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017561": {"description": "Alkyl hydroperoxide reductase F subunit homogue, putative", "go_ids": [], "go_terms": [], "name": "AhpF_homologue_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017562": {"description": "Cytochrome c-type biogenesis protein CcsA", "go_ids": ["GO:0017004"], "go_terms": ["GO:0017004:cytochrome complex assembly:P"], "name": "Cyt_c_biogenesis_CcsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017563": {"description": "Cytochrome c nitrate reductase biogenesis protein NrfE", "go_ids": [], "go_terms": [], "name": "CytC_NO3Rdtase_biogenesis_NrfE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017564": {"description": "Cytochrome c-type protein NrfB", "go_ids": ["GO:0042597", "GO:0020037"], "go_terms": ["GO:0042597:periplasmic space:C", "GO:0020037:heme binding:F"], "name": "Cyt_c_NrfB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017565": {"description": "Formate-dependent nitrite reductase complex, subunit NrfF", "go_ids": [], "go_terms": [], "name": "For-dep_Cytc_NO2Rdtase_NrfF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017566": {"description": "NrfD", "go_ids": [], "go_terms": [], "name": "NrfD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017567": {"description": "Cytochrome c nitrite reductase, Fe-S protein", "go_ids": [], "go_terms": [], "name": "Cyt_c_NO2Rdtase_NrfC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017568": {"description": "3-oxoacyl-[acyl-carrier-protein] synthase 2", "go_ids": ["GO:0006633", "GO:0016747"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P", "GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "3-oxoacyl-ACP_synth-2", "pathway_ids": ["PWY-8175", "PWY-8174", "PWY-5367", "PWY-5971", "PWY-7388", "PWY-5973", "PWY-8279", "PWY-8173", "R-SPO-9837999", "R-HSA-9837999", "R-MMU-9837999"], "pathways": ["PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-5367:t:petroselinate biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8279:t:palmitate biosynthesis III", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation"], "type": "Family"}, "IPR017569": {"description": "Enoyl-(acyl-carrier-protein) reductase II, putative", "go_ids": [], "go_terms": [], "name": "Enoyl_ACP_red-II_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017570": {"description": "Formate-dependent cytochrome c nitrite reductase, c552 subunit", "go_ids": ["GO:0005509", "GO:0020037", "GO:0042279", "GO:0042597"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0020037:heme binding:F", "GO:0042279:nitrite reductase (cytochrome, ammonia-forming) activity:F", "GO:0042597:periplasmic space:C"], "name": "Cyt_c_NO2Rdtase_formate-dep", "pathway_ids": ["PWY-5674"], "pathways": ["PWY-5674:t:nitrate reduction IV (dissimilatory)"], "type": "Family"}, "IPR017571": {"description": "Cytochrome c nitrite reductase, small subunit", "go_ids": ["GO:0016020", "GO:0022900"], 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"Dnd_assoc_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017647": {"description": "DNA phosphorothioation-dependent restriction protein DptF", "go_ids": [], "go_terms": [], "name": "Dnd_assoc_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017648": {"description": "5-keto-4-deoxy-D-glucarate aldolase", "go_ids": ["GO:0042838", "GO:0008672"], "go_terms": ["GO:0042838:D-glucarate catabolic process:P", "GO:0008672:2-dehydro-3-deoxyglucarate aldolase activity:F"], "name": "GarL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017649": {"description": "Succinylglutamate-semialdehyde dehydrogenase", "go_ids": ["GO:0006527", "GO:0043824"], "go_terms": ["GO:0006527:L-arginine catabolic process:P", "GO:0043824:succinylglutamate-semialdehyde dehydrogenase activity:F"], "name": "SuccinylGlu_semiald_DH_AstD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017650": {"description": "Arginine N-succinyltransferase", "go_ids": ["GO:0006527", "GO:0008791"], "go_terms": ["GO:0006527:L-arginine catabolic process:P", "GO:0008791:L-arginine N-succinyltransferase activity:F"], "name": "Arginine_N-succinylTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017651": {"description": "Arginine/ornithine succinyltransferase, alpha subunit", "go_ids": [], "go_terms": [], "name": "Arg/Orn_succinylTfrase_asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017652": {"description": "Acetyl/Succinylornithine transaminase family, bacteria", "go_ids": ["GO:0006520", "GO:0008483", "GO:0030170"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0008483:transaminase activity:F", "GO:0030170:pyridoxal phosphate binding:F"], "name": "Ac/SucOrn_transaminase_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017653": {"description": "Glucarate dehydratase", "go_ids": ["GO:0042838", "GO:0000287", "GO:0008872"], "go_terms": ["GO:0042838:D-glucarate catabolic process:P", "GO:0000287:magnesium ion 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degradation II"], "type": "Family"}, "IPR017656": {"description": "Putative phosphonoacetaldehyde dehydrogenase", "go_ids": [], "go_terms": [], "name": "Put_phosphonoacetaldehyde_DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017657": {"description": "L-lysine 6-transaminase", "go_ids": ["GO:0017000", "GO:0030170", "GO:0045484"], "go_terms": ["GO:0017000:antibiotic biosynthetic process:P", "GO:0030170:pyridoxal phosphate binding:F", "GO:0045484:L-lysine:2-oxoglutarate 6-transaminase activity:F"], "name": "L-lysine_6-transaminase", "pathway_ids": ["PWY-5298"], "pathways": ["PWY-5298:t:L-lysine degradation VI"], "type": "Family"}, "IPR017658": {"description": "HhH-GPD-type base excision DNA repair protein", "go_ids": [], "go_terms": [], "name": "HhH-GPD_base_excis", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017659": {"description": "Formyl-CoA:oxalate CoA-transferase", "go_ids": ["GO:0033608"], "go_terms": ["GO:0033608:formyl-CoA transferase activity:F"], "name": "Formyl_CoA_transfer", "pathway_ids": ["PWY-6695"], "pathways": ["PWY-6695:t:oxalate degradation II"], "type": "Family"}, "IPR017660": {"description": "Oxalyl-CoA decarboxylase", "go_ids": ["GO:0008949", "GO:0030976", "GO:0033611", "GO:0046872"], "go_terms": ["GO:0008949:oxalyl-CoA decarboxylase activity:F", "GO:0030976:thiamine pyrophosphate binding:F", "GO:0033611:oxalate catabolic process:P", "GO:0046872:metal ion binding:F"], "name": "Oxalyl-CoA_decarboxylase", "pathway_ids": ["PWY-6696", "PWY-7985", "PWY-6695"], "pathways": ["PWY-6696:t:oxalate degradation III", "PWY-7985:t:oxalate degradation VI", "PWY-6695:t:oxalate degradation II"], "type": "Family"}, "IPR017661": {"description": "2-aminoethylphosphonate ABC transport system, membrane component PhnV", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "AminoethylPonate_ABC_PhnV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017662": {"description": "2-aminoethylphosphonate ABC 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"R-SPO-499943", "R-HSA-499943", "R-DDI-499943", "R-MMU-499943"], "pathways": ["PWY-7221:t:guanosine ribonucleotides de novo biosynthesis", "PWY-8289:t:dZTP biosynthesis", "R-MMU-9748787:r:Azathioprine ADME", "R-SCE-9748787:r:Azathioprine ADME", "R-HSA-9748787:r:Azathioprine ADME", "R-DDI-9748787:r:Azathioprine ADME", "R-BTA-9748787:r:Azathioprine ADME", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-9748787:r:Azathioprine ADME", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR017666": {"description": "2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT2", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP 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"IPR017672": {"description": "Radical SAM methyltransferase MA_4551-like", "go_ids": [], "go_terms": [], "name": "MA_4551-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017673": {"description": "Putative radical SAM enzyme, CHP03279 family", "go_ids": [], "go_terms": [], "name": "CHP03279_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017674": {"description": "Methanogenesis marker 11 protein", "go_ids": [], "go_terms": [], "name": "Methan_mark_11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017675": {"description": "Ni-sirohydrochlorin a,c-diamide reductive cyclase complex, component CfbD", "go_ids": [], "go_terms": [], "name": "CfbD", "pathway_ids": ["PWY-5196"], "pathways": ["PWY-5196:t:factor 430 biosynthesis"], "type": "Family"}, "IPR017676": {"description": "Methanogenesis marker protein 15", "go_ids": [], "go_terms": [], "name": "Methan_mark_15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017677": {"description": 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{"description": "CoB--CoM heterodisulphide reductase, subunit C", "go_ids": ["GO:0015948", "GO:0051539", "GO:0051912"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0051912:CoB--CoM heterodisulfide reductase activity:F"], "name": "CoB/CoM_hetero-S_Rdtase_csu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017681": {"description": "Coenzyme F420 hydrogenase, subunit gamma", "go_ids": ["GO:0016151", "GO:0050454", "GO:0050660", "GO:0051536"], "go_terms": ["GO:0016151:nickel cation binding:F", "GO:0050454:coenzyme F420 hydrogenase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Coenz_F420_hydrogenase_gsu", "pathway_ids": ["PWY-5207"], "pathways": ["PWY-5207:t:coenzyme B/coenzyme M regeneration I (methanophenazine-dependent)"], "type": "Family"}, "IPR017682": {"description": "Coenzyme F420 hydrogenase, subunit alpha", "go_ids": ["GO:0016151", "GO:0050454", "GO:0050660", "GO:0051536"], "go_terms": ["GO:0016151:nickel cation binding:F", "GO:0050454:coenzyme F420 hydrogenase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "Coenz_F420_hydrogenase_asu", "pathway_ids": ["PWY-5207"], "pathways": ["PWY-5207:t:coenzyme B/coenzyme M regeneration I (methanophenazine-dependent)"], "type": "Family"}, "IPR017684": {"description": "Phosphonopyruvate decarboxylase", "go_ids": ["GO:0032923", "GO:0033980"], "go_terms": ["GO:0032923:organic phosphonate biosynthetic process:P", "GO:0033980:phosphonopyruvate decarboxylase activity:F"], "name": "Phosphono-pyrv_decarboxylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017685": {"description": "HTH-type transcriptional regulator ArgP", "go_ids": [], "go_terms": [], "name": "ArgP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017686": {"description": "Phage/plasmid-like protein", "go_ids": [], "go_terms": [], "name": "Phg/plasmid-like_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017687": {"description": "Outer membrane protein assembly factor BamB", "go_ids": [], "go_terms": [], "name": "BamB", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR017689": {"description": "Outer membrane protein assembly factor BamD", "go_ids": [], "go_terms": [], "name": "BamD", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR017691": {"description": "ATP synthase subunit beta, bacterial and archaeal", "go_ids": ["GO:0015986", "GO:0046933", "GO:0046961", "GO:0045259"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P", "GO:0046933:proton-transporting ATP synthase activity, rotational mechanism:F", "GO:0046961:proton-transporting ATPase activity, rotational mechanism:F", "GO:0045259:proton-transporting ATP synthase complex:C"], "name": "Alt_ATPase_F1_bsu", "pathway_ids": ["PWY-7980"], "pathways": ["PWY-7980:t:ATP biosynthesis"], "type": "Family"}, "IPR017692": {"description": "Alternate ATP synthase, F0complex, subunit A", "go_ids": [], "go_terms": [], "name": "Alt_ATP_synth_F0_Asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017693": {"description": "Phosphonate metabolism protein PhnP", "go_ids": ["GO:0019700", "GO:0008081"], "go_terms": ["GO:0019700:organic phosphonate catabolic process:P", "GO:0008081:phosphoric diester hydrolase activity:F"], "name": "Phosphonate_metab_PhnP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017694": {"description": "Phosphonate metabolism protein, transferase hexapeptide repeat family", "go_ids": [], "go_terms": [], "name": "Phosphonate_tfrase_rpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017695": {"description": "Selenium-dependent molybdenum hydroxylase system protein, YqeB family", "go_ids": [], "go_terms": [], "name": 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[], "type": "Family"}, "IPR017701": {"description": "Putative selenate reductase YgfK", "go_ids": [], "go_terms": [], "name": "Se_rdtase_YgfK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017702": {"description": "Putative carbamoyltransferase YgeW", "go_ids": [], "go_terms": [], "name": "Carbamoyltransferase_YgeW", "pathway_ids": ["PWY-8344", "PWY-7694", "PWY-7693", "PWY-8039", "PWY-5"], "pathways": ["PWY-8344:t:ansamitocin P biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-5:t:canavanine biosynthesis"], "type": "Family"}, "IPR017703": {"description": "YgfZ/CAF17, C-terminal", "go_ids": [], "go_terms": [], "name": "YgfZ/CAF17_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017704": {"description": "Putative selenium-binding protein YdfZ", "go_ids": [], "go_terms": [], "name": "Se-bd_putative_YdfZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017705": {"description": "Ribonuclease Y", "go_ids": ["GO:0003723", "GO:0016020", "GO:0006402"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0016020:membrane:C", "GO:0006402:mRNA catabolic process:P"], "name": "Ribonuclease_Y", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017706": {"description": "Uncharacterized protein YgeY", "go_ids": [], "go_terms": [], "name": "YgeY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017707": {"description": "Alternate ATP synthase, F0 complex, subunit b", "go_ids": [], "go_terms": [], "name": "Alt_ATP_synth_F0_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017708": {"description": "Alternate ATP synthase, F0 complex, subunit C, bacterial/archaeal", "go_ids": [], "go_terms": [], "name": "Alt_ATP_synth_F0_Csu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017709": {"description": "Alternate ATP synthase, F1 complex, subunit gamma", "go_ids": [], "go_terms": [], "name": "Alt_ATP_synth_F1_gsu", 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"R-XTR-111458", "R-BTA-111458", "R-HSA-9627069", "R-HSA-111458", "R-MMU-111458", "R-GGA-111458", "R-GGA-9627069", "R-BTA-9627069", "R-HSA-1237112"], "pathways": ["PWY-4361:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I", "R-XTR-9627069:r:Regulation of the apoptosome activity", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DME-111458:r:Formation of apoptosome", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-DRE-111458:r:Formation of apoptosome", "R-XTR-111458:r:Formation of apoptosome", "R-BTA-111458:r:Formation of apoptosome", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-111458:r:Formation of apoptosome", "R-MMU-111458:r:Formation of apoptosome", "R-GGA-111458:r:Formation of apoptosome", "R-GGA-9627069:r:Regulation of the apoptosome activity", "R-BTA-9627069:r:Regulation of the apoptosome activity", "R-HSA-1237112:r:Methionine salvage pathway"], "type": "Family"}, 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"name": "G3P_DH_GlpC_su", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017754": {"description": "Agmatine deiminase", "go_ids": ["GO:0009446", "GO:0047632"], "go_terms": ["GO:0009446:putrescine biosynthetic process:P", "GO:0047632:agmatine deiminase activity:F"], "name": "Agmatine_deiminase", "pathway_ids": ["PWY-43"], "pathways": ["PWY-43:t:putrescine biosynthesis II"], "type": "Family"}, "IPR017755": {"description": "N-carbamoylputrescine amidase", "go_ids": ["GO:0006596", "GO:0050126"], "go_terms": ["GO:0006596:polyamine biosynthetic process:P", "GO:0050126:N-carbamoylputrescine amidase activity:F"], "name": "N-carbamoylputrescine_amidase", "pathway_ids": ["PWY-43"], "pathways": ["PWY-43:t:putrescine biosynthesis II"], "type": "Family"}, "IPR017756": {"description": "Transmembrane Gly-Cys-Arg, conserved site", "go_ids": [], "go_terms": [], "name": "TM_Gly-Cys-Arg_CS", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR017757": {"description": 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{"description": "Frataxin", "go_ids": ["GO:0004322", "GO:0006879", "GO:0018283", "GO:0005739"], "go_terms": ["GO:0004322:ferroxidase activity:F", "GO:0006879:intracellular iron ion homeostasis:P", "GO:0018283:iron incorporation into metallo-sulfur cluster:P", "GO:0005739:mitochondrion:C"], "name": "Frataxin", "pathway_ids": ["R-HSA-1362409", "R-HSA-9865881", "R-HSA-9854311", "R-RNO-1268020", "R-BTA-9854311", "R-SCE-1362409", "R-RNO-1362409", "R-SPO-9854311", "R-DDI-1362409", "R-SCE-9865881", "R-CEL-1362409", "R-SPO-1268020", "R-DME-9865881", "R-MMU-9865881", "R-SPO-9865881", "R-RNO-9854311", "R-DME-9854311", "R-MMU-9854311", "R-HSA-1268020", "R-DDI-9865881", "R-MMU-1362409", "R-MMU-1268020", "R-BTA-1268020", "R-CEL-9854311", "R-DDI-9854311", "R-RNO-9865881", "R-BTA-9865881", "R-BTA-1362409", "R-SCE-1268020", "R-SPO-1362409", "R-SCE-9854311", "R-DME-1362409"], "pathways": ["R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9865881:r:Complex III assembly", 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"R-HSA-9953038", "R-DME-975578", "R-SPO-189085", "R-CEL-9840310", "R-CEL-8853383", "R-MMU-5654687", "R-MMU-1307965", "R-MMU-5654693", "R-MMU-5654689", "R-RNO-5654219", "R-DDI-2024101", "R-HSA-5654688", "R-HSA-6798695", "R-SSC-2160916", "R-RNO-5654726", "R-MMU-2024096", "R-CEL-6798695", "R-HSA-5654228", "R-BTA-6798695", "R-MMU-8957275", "R-HSA-5654693", "R-CEL-975578", "R-RNO-2024096", "R-HSA-2142845", "R-SCE-70221", "R-HSA-3322077", "R-SPO-70221", "R-CEL-8957275", "R-CEL-381426", "R-CFA-2024101", "R-MMU-381426", "R-HSA-4085001", "R-HSA-901042", "R-SSC-189085", "R-RNO-5673001", "R-HSA-381426", "R-MTU-868688", "R-HSA-2024101", "R-HSA-9953111", "R-HSA-70221", "R-RNO-5654693", "R-CEL-2024101", "R-BTA-975578", "R-HSA-3656234", "R-HSA-2219530", "R-MMU-2160916", "R-MMU-2142845", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-381426", "R-HSA-2206282", "R-RNO-8853383", "R-HSA-5660862", "R-HSA-5654720", "R-HSA-3878781", "R-MMU-6798695", "R-MMU-5654688", "R-HSA-964739", "R-HSA-5654733", "R-HSA-1257604", "R-XTR-114608", "R-SCE-352230", "R-MMU-114608", "R-DDI-9840310", "R-HSA-1307965", "R-SPO-6798695", "R-HSA-9683686", "R-MMU-8853383", "R-MMU-3322077", "R-DME-381426", "R-DME-8957275", "R-HSA-975578", "R-HSA-5654687", "R-RNO-109704", "R-HSA-9925561", "R-RNO-114608", "R-CEL-189085", "R-BTA-114608", "R-RNO-8957275", "R-RNO-2024101", "R-HSA-5659898", "R-HSA-2024096", "R-BTA-2160916", "R-SSC-2024101", "R-RNO-5654687", "R-MMU-5654228", "R-RNO-71240", "R-MMU-189085", "R-MMU-5654719", "R-BTA-2024101", "R-HSA-5660883", "R-DME-2024096", "R-DDI-975578", "R-RNO-210991", "R-HSA-390471", "R-MMU-71240", "R-HSA-2160916", "R-HSA-3656248", "R-HSA-5619113", "R-CEL-2534343", "R-HSA-9953080", "R-HSA-2534343", "R-PFA-6798695", "R-HSA-4341670", "R-MMU-5654733", "R-RNO-975578", "R-HSA-8957275", "R-RNO-2160916", "R-BTA-2022857", "R-HSA-2206308"], "pathways": ["R-HSA-71240:r:Tryptophan catabolism", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-RNO-9840310:r:Glycosphingolipid 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"R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-9953097:r:MPS IX - Natowicz syndrome (CS/DS degradation)", "R-CEL-2022857:r:Keratan sulfate degradation", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-2024101:r:CS/DS degradation", "R-DDI-2022857:r:Keratan sulfate degradation", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-DDI-2160916:r:Hyaluronan degradation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-CFA-2024096:r:HS-GAG degradation", "R-SSC-6798695:r:Neutrophil degranulation", "R-DRE-114608:r:Platelet degranulation", "R-HSA-9694548:r:Maturation of spike protein", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-2206292:r:MPS VII - Sly syndrome (Hyaluronan metabolism)", "R-MMU-352230:r:Amino acid transport across the plasma membrane", "R-HSA-114608:r:Platelet degranulation", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-2024101:r:CS/DS degradation", "R-MMU-4085001:r:Sialic acid metabolism", "R-SCE-189085:r:Digestion of dietary carbohydrate", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-189085:r:Digestion of dietary carbohydrate", "R-MMU-109704:r:PI3K Cascade", "R-HSA-2206280:r:MPS IX - Natowicz syndrome (Hyaluronan metabolism)", "R-PFA-189085:r:Digestion of dietary carbohydrate", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-5357609:r:Glycogen storage disease type II (GAA)", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-109704:r:PI3K Cascade", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-SCE-3322077:r:Glycogen synthesis", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-CEL-2160916:r:Hyaluronan degradation", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9953038:r:MPS I - Hurler syndrome (CS/DS degradation)", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-SPO-189085:r:Digestion of dietary carbohydrate", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-CEL-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DDI-2024101:r:CS/DS degradation", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-2160916:r:Hyaluronan degradation", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-2024096:r:HS-GAG degradation", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-CEL-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-RNO-2024096:r:HS-GAG degradation", "R-HSA-2142845:r:Hyaluronan metabolism", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-3322077:r:Glycogen synthesis", "R-SPO-70221:r:Glycogen breakdown (glycogenolysis)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CFA-2024101:r:CS/DS degradation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-4085001:r:Sialic acid metabolism", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-SSC-189085:r:Digestion of dietary carbohydrate", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MTU-868688:r:Trehalose biosynthesis", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-9953111:r:MPS IV - Morquio syndrome B (CS/DS degradation)", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-CEL-2024101:r:CS/DS degradation", "R-BTA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-3656234:r:Defective HEXA causes GM2G1 (Hyaluronan metabolism)", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2206282:r:MPS IIIB - Sanfilippo syndrome B", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-5660862:r:Defective SLC7A7 causes lysinuric protein intolerance (LPI)", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-HSA-3878781:r:Glycogen storage disease type IV (GBE1)", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-XTR-114608:r:Platelet degranulation", "R-SCE-352230:r:Amino acid transport across the plasma membrane", "R-MMU-114608:r:Platelet degranulation", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9683686:r:Maturation of spike protein", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-3322077:r:Glycogen synthesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-109704:r:PI3K Cascade", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-RNO-114608:r:Platelet degranulation", "R-CEL-189085:r:Digestion of dietary carbohydrate", "R-BTA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-5659898:r:Intestinal saccharidase deficiencies", "R-HSA-2024096:r:HS-GAG degradation", "R-BTA-2160916:r:Hyaluronan degradation", "R-SSC-2024101:r:CS/DS degradation", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-71240:r:Tryptophan catabolism", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-2024101:r:CS/DS degradation", "R-HSA-5660883:r:Defective SLC7A9 causes cystinuria (CSNU)", "R-DME-2024096:r:HS-GAG degradation", "R-DDI-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-RNO-210991:r:Basigin interactions", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-71240:r:Tryptophan catabolism", "R-HSA-2160916:r:Hyaluronan degradation", "R-HSA-3656248:r:Defective HEXB causes GM2G2 (Hyaluronan metabolism)", "R-HSA-5619113:r:Defective SLC3A1 causes cystinuria (CSNU)", "R-CEL-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-9953080:r:MPS VII - Sly syndrome (CS/DS degradation)", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-PFA-6798695:r:Neutrophil degranulation", "R-HSA-4341670:r:Defective NEU1 causes sialidosis", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-2160916:r:Hyaluronan degradation", "R-BTA-2022857:r:Keratan sulfate degradation", "R-HSA-2206308:r:MPS IV - Morquio syndrome B (Keratin metabolism)"], "type": "Homologous_superfamily"}, 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"R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-9629569:r:Protein hydroxylation", "R-HSA-9673218:r:Defective F9 secretion", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-CFA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-CFA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9673221:r:Defective F9 activation", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-GGA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-CFA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-9672383:r:Defective factor IX causes thrombophilia"], "type": "Homologous_superfamily"}, "IPR017859": {"description": "Treacle protein", "go_ids": [], "go_terms": [], "name": "Treacle", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017861": {"description": "Kae1/TsaD family", "go_ids": [], "go_terms": [], "name": "KAE1/TsaD", "pathway_ids": ["R-HSA-6782315", "R-HSA-6787450"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Family"}, "IPR017862": {"description": "SKI-interacting protein, SKIP", "go_ids": ["GO:0000398", "GO:0005681"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P", "GO:0005681:spliceosomal complex:C"], "name": "SKI-int_prot_SKIP", "pathway_ids": ["R-HSA-2122947", "R-HSA-9918481", "R-BTA-72163", "R-MMU-2173795", "R-CEL-2173795", "R-DME-350054", "R-HSA-9013508", "R-HSA-8941856", "R-HSA-210744", "R-MMU-72163", "R-MMU-2122947", "R-HSA-2894862", "R-DME-72163", "R-DME-2173795", "R-DDI-72163", "R-BTA-8941856", "R-HSA-350054", "R-BTA-350054", "R-HSA-1912408", "R-HSA-72163", "R-HSA-9013695", "R-MMU-350054", "R-HSA-2173795", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-BTA-2173795", "R-CEL-72163", "R-SPO-72163"], "pathways": ["R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-350054:r:Notch-HLH transcription pathway", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-BTA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR017867": {"description": "Protein-tyrosine phosphatase, low molecular weight", "go_ids": ["GO:0004725", "GO:0006470"], "go_terms": ["GO:0004725:protein tyrosine phosphatase activity:F", "GO:0006470:protein dephosphorylation:P"], "name": "Tyr_phospatase_low_mol_wt", "pathway_ids": ["R-HSA-9636383", "R-HSA-9637628", "R-HSA-9636467", "R-HSA-9635465"], "pathways": ["R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-HSA-9636467:r:Blockage of phagosome acidification", "R-HSA-9635465:r:Suppression of apoptosis"], "type": "Family"}, "IPR017868": {"description": "Filamin/ABP280 repeat-like", "go_ids": [], "go_terms": [], "name": "Filamin/ABP280_rpt-like", "pathway_ids": ["R-MMU-446353", "R-HSA-8983711", "R-RNO-446353", "R-MMU-430116", "R-DME-114608", "R-HSA-430116", "R-DME-5627123", "R-HSA-983168", "R-HSA-1169408", "R-MMU-1169408", "R-DRE-983168", "R-HSA-114608", "R-HSA-5627123", "R-HSA-446353", "R-HSA-877300", "R-MMU-983168", "R-MMU-5627123", "R-DME-446353", "R-RNO-983168", "R-MMU-114608"], "pathways": ["R-MMU-446353:r:Cell-extracellular matrix interactions", "R-HSA-8983711:r:OAS antiviral response", "R-RNO-446353:r:Cell-extracellular matrix interactions", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-DME-114608:r:Platelet degranulation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-114608:r:Platelet degranulation"], "type": "Repeat"}, "IPR017874": {"description": "CRIC domain", "go_ids": [], "go_terms": [], "name": "CRIC_domain", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-9649948", "R-HSA-6802952", "R-HSA-6802946", "R-RNO-5674135", "R-CEL-5674135", "R-HSA-6802955", "R-HSA-9656223"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Domain"}, "IPR017878": {"description": "TB domain", "go_ids": [], "go_terms": [], "name": "TB_dom", "pathway_ids": ["R-HSA-1474228", "R-SSC-2473224", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-216083", "R-BTA-1566948", "R-BTA-1474228", "R-HSA-1566948", "R-BTA-2173789", "R-BTA-2473224", "R-HSA-2473224", "R-MMU-8957275", "R-RNO-2129379", "R-BTA-8957275", "R-RNO-381426", "R-DRE-2473224", "R-RNO-2473224", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-MMU-216083", "R-HSA-8957275", "R-MMU-2473224", "R-MMU-1566948", "R-BTA-216083", "R-BTA-2129379", "R-RNO-2173789", "R-HSA-381426", "R-HSA-2173789", "R-MMU-2129379", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-SSC-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-BTA-1566948:r:Elastic fibre formation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-1566948:r:Elastic fibre formation", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-2473224:r:Antagonism of Activin by Follistatin", "R-RNO-2473224:r:Antagonism of Activin by Follistatin", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-1566948:r:Elastic fibre formation", "R-BTA-216083:r:Integrin cell surface interactions", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR017881": {"description": "Nitrite reductase (NADH) small subunit", "go_ids": ["GO:0008942"], "go_terms": ["GO:0008942:nitrite reductase [NAD(P)H] activity:F"], "name": "NirD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017887": {"description": "Transcription factor TCP subgroup", "go_ids": [], "go_terms": [], "name": "TF_TCP_subgr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR017892": {"description": "Protein kinase, C-terminal", "go_ids": ["GO:0004674", "GO:0005524", "GO:0006468"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006468:protein phosphorylation:P"], "name": "Pkinase_C", "pathway_ids": ["R-RNO-114508", "R-DDI-198693", "R-CEL-198693", "R-HSA-2173791", "R-RNO-76005", "R-HSA-9824585", "R-RNO-5607764", "R-SPO-6804758", "R-GGA-2672351", "R-DME-114516", "R-HSA-444257", "R-HSA-69202", "R-SCE-444257", "R-SCE-202424", "R-HSA-392451", "R-CEL-5218920", "R-HSA-9013409", "R-SPO-2029485", "R-CEL-9634638", "R-MMU-198323", "R-SPO-389357", "R-MMU-881907", "R-RNO-9009391", "R-HSA-1489509", "R-HSA-9856532", "R-RNO-1433559", "R-DME-5218921", "R-RNO-111465", "R-SCE-881907", "R-HSA-5218920", "R-SCE-6804757", "R-HSA-8853659", "R-SPO-5668599", "R-DDI-5218920", "R-CEL-3000170", "R-HSA-165181", "R-GGA-9031628", "R-SPO-392451", "R-BTA-5625740", "R-SPO-9031628", "R-HSA-111447", "R-RNO-5628897", "R-MMU-9031628", "R-CEL-9648002", "R-DME-450604", "R-GGA-199920", "R-MMU-165181", "R-HSA-1445148", "R-HSA-111933", "R-MMU-6804758", "R-HSA-9013026", "R-DRE-6804757", "R-DME-389357", "R-DME-373752", "R-DME-1358803", "R-HSA-5625900", "R-DDI-165159", "R-MMU-8980692", "R-CEL-1489509", "R-SCE-6798695", "R-HSA-2029485", "R-HSA-9013106", "R-DME-114508", "R-CEL-5607764", "R-SPO-5218921", "R-HSA-9614399", "R-RNO-399997", "R-SCE-6804758", "R-DRE-1912408", "R-CEL-69656", "R-CEL-354192", "R-CEL-373752", "R-HSA-1250196", "R-HSA-4086398", "R-SPO-6804757", "R-SPO-198693", "R-DRE-9031628", "R-MMU-202424", "R-SCE-5625740", "R-HSA-389513", "R-RNO-9856649", "R-MMU-6804757", "R-HSA-9841251", "R-DME-9856649", "R-RNO-392451", "R-MMU-1169091", "R-HSA-9755779", "R-RNO-9856530", "R-HSA-450385", "R-SCE-392451", "R-MMU-444257", "R-SPO-199418", "R-HSA-111465", "R-CEL-166208", "R-SCE-5218920", "R-CEL-9856530", "R-MMU-9607240", "R-DME-199920", "R-MMU-5607764", "R-SCE-2559582", "R-SCE-450385", "R-SPO-9013106", "R-DME-111465", "R-SCE-5607764", "R-CEL-114508", "R-CEL-1433559", "R-MMU-5668599", "R-RNO-202424", "R-RNO-9013406", "R-CEL-9856649", "R-DME-6804759", "R-SCE-9856530", "R-CEL-203615", "R-RNO-389357", "R-RNO-199418", "R-SPO-5607764", "R-CEL-199920", "R-RNO-8853659", "R-HSA-9755511", "R-DME-2173791", "R-GGA-5621575", "R-RNO-420029", "R-MMU-111933", "R-MMU-9604323", "R-DME-3769402", "R-DME-399997", "R-HSA-9013149", "R-SPO-389513", "R-HSA-1169091", "R-HSA-8980692", "R-RNO-389513", "R-HSA-8948751", "R-MMU-199418", "R-SPO-2179392", "R-BTA-9013106", "R-MMU-375165", "R-CEL-375165", "R-SPO-1489509", "R-DME-392451", "R-HSA-209543", "R-MMU-203615", "R-RNO-9841251", "R-DDI-9013149", "R-HSA-1912408", "R-SCE-1169091", "R-DME-6811558", "R-SCE-8948751", "R-RNO-2672351", "R-CEL-8876198", "R-SCE-1257604", "R-MMU-5625886", "R-DRE-5099900", "R-RNO-9013106", "R-DRE-9856530", "R-RNO-5099900", "R-SPO-1257604", "R-HSA-5607764", "R-DME-1489509", "R-MMU-1358803", "R-DME-4419969", "R-HSA-354192", "R-MMU-416993", "R-MMU-3769402", "R-MMU-8849469", "R-CEL-9841251", "R-RNO-9634635", "R-RNO-5625900", "R-RNO-5218921", "R-DDI-5607764", "R-MMU-166208", "R-DDI-114508", "R-MMU-9634638", "R-SCE-5668599", "R-HSA-8939246", "R-HSA-2028269", "R-SCE-2871837", "R-XTR-1169091", "R-RNO-9013026", "R-DME-198323", "R-CEL-444257", "R-HSA-9604323", "R-CEL-442742", "R-HSA-8936459", "R-SPO-165181", "R-HSA-9010642", "R-DDI-202424", "R-DME-198693", "R-HSA-76005", "R-HSA-69656", "R-SCE-8980692", "R-SCE-166208", "R-DME-211163", "R-SCE-165158", "R-DDI-399997", "R-RNO-165159", "R-DDI-6798695", "R-DME-9607240", "R-SPO-6811558", "R-HSA-373752", "R-SCE-1489509", "R-RNO-6804759", "R-HSA-450604", "R-DRE-8980692", "R-MMU-1250196", "R-SCE-389513", "R-DME-165159", "R-DDI-9013418", "R-DME-202424", "R-RNO-198693", "R-RNO-165181", "R-DME-111933", "R-XTR-4419969", "R-RNO-199920", "R-SCE-76005", "R-RNO-166208", "R-RNO-450604", "R-SPO-114516", "R-HSA-166208", "R-DME-199418", "R-RNO-354192", "R-MMU-2672351", "R-HSA-9013148", "R-SCE-4419969", "R-DDI-5628897", "R-CEL-881907", "R-DDI-1474151", "R-CEL-9755511", "R-MMU-114516", "R-DME-2179392", "R-RNO-9755511", "R-DME-6798695", "R-MMU-1474151", "R-BTA-9013422", "R-HSA-9009391", "R-SPO-2871837", "R-DDI-4419969", "R-DRE-1257604", "R-CEL-5218921", "R-HSA-5668599", "R-CEL-2029485", "R-DME-69656", "R-MMU-9856649", "R-HSA-8849469", "R-DDI-5218921", "R-HSA-6798695", "R-CEL-6798695", "R-MMU-2173791", "R-SCE-389357", "R-SPO-76005", "R-SPO-198323", "R-SCE-6811558", "R-CEL-2871837", "R-CEL-2559582", "R-SPO-9009391", "R-MMU-392451", "R-DDI-9841251", "R-MMU-2029485", "R-RNO-198323", "R-RNO-165158", "R-MMU-165159", "R-CEL-1912408", "R-DDI-8948751", "R-CEL-389513", "R-HSA-199920", "R-DME-450520", "R-RNO-2173791", "R-HSA-6811558", "R-RNO-1433557", "R-DRE-209543", "R-DDI-9856530", "R-DME-1250196", "R-MMU-450604", "R-MMU-76005", "R-DDI-5625740", "R-DME-76005", "R-DME-5607764", "R-HSA-1257604", "R-DME-2871837", "R-SPO-6798695", "R-MMU-2179392", "R-DME-416993", "R-RNO-114516", "R-DME-9634638", "R-MMU-9856530", "R-MMU-9648002", "R-BTA-416993", "R-RNO-8876198", "R-DDI-2871837", "R-XTR-5668599", "R-DDI-76005", "R-GGA-198753", "R-HSA-114508", "R-DDI-1169091", "R-MMU-198693", "R-DDI-165181", "R-MMU-5218921", "R-SPO-9856530", "R-GGA-1257604", "R-RNO-69202", "R-MMU-2028269", "R-DDI-1257604", "R-DME-8876198", "R-MMU-5218920", "R-SCE-114516", "R-CEL-9614399", "R-CEL-9634635", "R-SPO-4419969", "R-DRE-5625740", "R-GGA-6804757", "R-DRE-4419969", "R-DME-450385", "R-DME-3000170", "R-RNO-1169091", "R-SCE-114508", "R-BTA-4419969", "R-HSA-165159", "R-CEL-399997", "R-HSA-9013406", "R-HSA-202424", "R-RNO-2871837", "R-XTR-76005", "R-SCE-399997", "R-HSA-9607240", "R-RNO-8948751", "R-DRE-1169091", "R-HSA-9013418", "R-RNO-442742", "R-DRE-442742", "R-RNO-9607240", "R-CEL-114516", "R-MMU-9009391", "R-DDI-2179392", "R-DME-9634635", "R-MMU-3000170", "R-HSA-6804759", "R-XTR-114516", "R-MMU-211163", "R-RNO-6811558", "R-CEL-1257604", "R-HSA-199418", "R-RNO-450385", "R-CEL-165159", "R-MMU-1489509", "R-SPO-9634635", "R-HSA-114604", "R-DME-1433559", "R-DME-9013149", "R-HSA-198753", "R-DME-198753", "R-DME-69202", "R-CEL-450604", "R-MMU-2559582", "R-DDI-392451", "R-DME-9648002", "R-DRE-9755511", "R-MMU-69656", "R-HSA-1433559", "R-RNO-881907", "R-MMU-9841251", "R-MMU-1912408", "R-DME-1257604", "R-HSA-418597", "R-DME-110523", "R-HSA-8986944", "R-HSA-9031628", "R-HSA-9648002", "R-CEL-199418", "R-CEL-165158", "R-RNO-6798695", "R-SCE-2179392", "R-HSA-1474151", "R-DDI-199418", "R-HSA-2672351", "R-HSA-9634635", "R-DME-5625740", "R-CEL-389357", "R-CEL-111933", "R-MMU-165158", "R-MMU-6804759", "R-MMU-111465", "R-DME-389513", "R-DRE-114516", "R-HSA-416993", "R-SPO-114508", "R-SPO-1169091", "R-DME-9013422", "R-DME-203615", "R-SCE-9013106", "R-SCE-5218921", "R-HSA-877300", "R-RNO-3769402", "R-HSA-9856530", "R-CEL-9009391", "R-MMU-9013149", "R-RNO-3000170", "R-MMU-373752", "R-DME-9856530", "R-HSA-9013422", "R-DME-375165", "R-SCE-2029485", "R-DME-5621575", "R-RNO-9013149", "R-HSA-2179392", "R-CEL-198753", "R-DRE-5218921", "R-MMU-9013422", "R-RNO-2029485", "R-RNO-5625740", "R-RNO-2179392", "R-MMU-5628897", "R-DME-6804758", "R-BTA-9013418", "R-DRE-9013106", "R-MMU-420029", "R-DME-8980692", "R-HSA-2514859", "R-MMU-8853659", "R-CEL-76005", "R-MMU-450520", "R-HSA-6785807", "R-CEL-202424", "R-DME-354192", "R-DME-9755511", "R-MMU-9634635", "R-DME-110478", "R-DME-165158", "R-MMU-2871837", "R-RNO-1358803", "R-SCE-203615", "R-RNO-4419969", "R-SPO-8948751", "R-DME-5628897", "R-HSA-114516", "R-DME-1169091", "R-HSA-3769402", "R-CEL-8849469", "R-RNO-111933", "R-MMU-199920", "R-DDI-198323", "R-DRE-444257", "R-BTA-114516", "R-HSA-2559582", "R-HSA-399997", "R-HSA-5628897", "R-CEL-9013149", "R-HSA-198323", "R-SCE-9634635", "R-RNO-5625886", "R-DDI-389513", "R-RNO-373752", "R-RNO-9648002", "R-HSA-211163", "R-HSA-1433557", "R-MMU-877300", "R-DDI-165158", "R-DME-9013418", "R-SPO-203615", "R-DME-9614399", "R-BTA-5218921", "R-MMU-9013026", "R-DDI-389357", "R-MMU-4419969", "R-RNO-1250196", "R-RNO-198753", "R-SCE-198753", "R-RNO-9604323", "R-CEL-211163", "R-RNO-9031628", "R-DDI-114516", "R-BTA-5625886", "R-MMU-6811558", "R-CEL-450385", "R-HSA-420029", "R-SCE-9841251", "R-MMU-8948751", "R-DME-8948751", "R-RNO-5218920", "R-HSA-203615", "R-SCE-198323", "R-CEL-9607240", "R-BTA-1169091", "R-DDI-2029485", "R-DME-2029485", "R-DDI-9634635", "R-BTA-5099900", "R-HSA-5674400", "R-GGA-375165", "R-DME-5625886", "R-MMU-5625900", "R-HSA-437239", "R-SCE-1474151", "R-HSA-8941332", "R-RNO-209543", "R-RNO-203615", "R-DME-5218920", "R-RNO-6804757", "R-SPO-9841251", "R-MMU-399997", "R-DRE-9013026", "R-BTA-8980692", "R-HSA-389357", "R-CEL-8948751", "R-CEL-6811558", "R-MMU-9013418", "R-MMU-354192", "R-RNO-9634638", "R-MMU-9614399", "R-DDI-9009391", "R-RNO-8980692", "R-RNO-1257604", "R-HSA-5625740", "R-CEL-2179392", "R-RNO-1489509", "R-HSA-5625886", "R-DDI-9013422", "R-SPO-5625740", "R-MMU-69202", "R-BTA-76005", "R-CEL-9013406", "R-CEL-1474151", "R-SPO-399997", "R-SCE-9031628", "R-MMU-114508", "R-DME-165181", "R-DRE-420029", "R-HSA-3000170", "R-SPO-5628897", "R-SCE-9009391", "R-HSA-5099900", "R-MMU-1257604", "R-RNO-9614399", "R-HSA-1358803", "R-HSA-9634638", "R-DDI-9648002", "R-MMU-389513", "R-DDI-450385", "R-MMU-198753", "R-HSA-9856649", "R-CEL-198323", "R-SCE-198693", "R-RNO-416993", "R-RNO-877300", "R-MMU-1433559", "R-DME-9604323", "R-RNO-2559582", "R-MMU-9013106", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-4419969", "R-MMU-5625740", "R-SPO-202424", "R-HSA-881907", "R-DDI-6804757", "R-MMU-389357", "R-CEL-1169091", "R-XTR-5099900", "R-HSA-6804757", "R-RNO-1474151", "R-DRE-76005", "R-DRE-5668599", "R-MMU-1433557", "R-SPO-165158", "R-MMU-5621575", "R-MMU-209543", "R-MMU-442742", "R-DRE-416993", "R-HSA-450520", "R-SPO-5218920", "R-HSA-8876198", "R-DDI-203615", "R-XTR-5218921", "R-HSA-5218921", "R-SPO-8980692", "R-RNO-6804758", "R-CEL-6804758", "R-BTA-5668599", "R-HSA-4419969", "R-MMU-8876198", "R-DME-9841251", "R-MMU-9013406", "R-MMU-6798695", "R-DDI-9031628", "R-DME-1474151", "R-RNO-211163", "R-HSA-165160", "R-DDI-1489509", "R-HSA-165158", "R-MMU-450385", "R-RNO-444257", "R-CEL-69202", "R-CEL-392451", "R-HSA-198693", "R-SCE-9856649", "R-SPO-1474151", "R-DDI-6811558", "R-RNO-450520", "R-MMU-9755511", "R-HSA-375165", "R-RNO-1912408", "R-RNO-5668599", "R-HSA-6804758", "R-HSA-2871837", "R-RNO-8849469", "R-HSA-442742", "R-HSA-5621575", "R-DME-9013406", "R-DRE-9013149", "R-RNO-69656", "R-DME-9009391"], "pathways": ["R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-DDI-198693:r:AKT phosphorylates targets in the nucleus", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-GGA-2672351:r:Stimuli-sensing channels", "R-DME-114516:r:Disinhibition of SNARE formation", "R-HSA-444257:r:RSK activation", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-SCE-444257:r:RSK activation", "R-SCE-202424:r:Downstream TCR signaling", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-CEL-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1489509:r:DAG and IP3 signaling", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-RNO-1433559:r:Regulation of KIT signaling", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-SCE-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-HSA-8853659:r:RET signaling", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-3000170:r:Syndecan interactions", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-GGA-9031628:r:NGF-stimulated transcription", "R-SPO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-SPO-9031628:r:NGF-stimulated transcription", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9031628:r:NGF-stimulated transcription", "R-CEL-9648002:r:RAS processing", "R-DME-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-GGA-199920:r:CREB phosphorylation", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-111933:r:Calmodulin induced events", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-373752:r:Netrin-1 signaling", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-DDI-165159:r:MTOR signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-1489509:r:DAG and IP3 signaling", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-1912408:r:Pre-NOTCH Transcription and Translation", "R-CEL-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-354192:r:Integrin signaling", "R-CEL-373752:r:Netrin-1 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-4086398:r:Ca2+ pathway", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-198693:r:AKT phosphorylates targets in the nucleus", "R-DRE-9031628:r:NGF-stimulated transcription", "R-MMU-202424:r:Downstream TCR signaling", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-444257:r:RSK activation", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-166208:r:mTORC1-mediated signalling", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9607240:r:FLT3 Signaling", "R-DME-199920:r:CREB phosphorylation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-SCE-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SPO-9013106:r:RHOC GTPase cycle", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-CEL-1433559:r:Regulation of KIT signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-202424:r:Downstream TCR signaling", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-203615:r:eNOS activation", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-199920:r:CREB phosphorylation", "R-RNO-8853659:r:RET signaling", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-420029:r:Tight junction interactions", "R-MMU-111933:r:Calmodulin induced events", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-SPO-2179392:r:EGFR Transactivation by Gastrin", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-SPO-1489509:r:DAG and IP3 signaling", "R-DME-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-MMU-203615:r:eNOS activation", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-SCE-1169091:r:Activation of NF-kappaB in B cells", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-RNO-2672351:r:Stimuli-sensing channels", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DRE-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-9013106:r:RHOC GTPase cycle", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-1489509:r:DAG and IP3 signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-354192:r:Integrin signaling", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DDI-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-2028269:r:Signaling by Hippo", "R-SCE-2871837:r:FCERI mediated NF-kB activation", "R-XTR-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-9013026:r:RHOB GTPase cycle", "R-DME-198323:r:AKT phosphorylates targets in the cytosol", "R-CEL-444257:r:RSK activation", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-CEL-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-DDI-202424:r:Downstream TCR signaling", "R-DME-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-SCE-8980692:r:RHOA GTPase cycle", 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"R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-354192:r:Integrin signaling", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-1489509:r:DAG and IP3 signaling", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-BTA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SPO-399997:r:Acetylcholine regulates insulin secretion", "R-SCE-9031628:r:NGF-stimulated transcription", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-DME-165181:r:Inhibition of TSC complex formation by PKB", "R-DRE-420029:r:Tight junction interactions", "R-HSA-3000170:r:Syndecan interactions", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DDI-9648002:r:RAS processing", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-198753:r:ERK/MAPK targets", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-SCE-198693:r:AKT phosphorylates targets in the nucleus", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-877300:r:Interferon gamma signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-SPO-202424:r:Downstream TCR signaling", "R-HSA-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-1169091:r:Activation of NF-kappaB in B cells", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DRE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DRE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-SPO-165158:r:Activation of AKT2", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-MMU-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-DRE-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-203615:r:eNOS activation", "R-XTR-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-CEL-6804758:r:Regulation of TP53 Activity through Acetylation", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9031628:r:NGF-stimulated transcription", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-211163:r:AKT-mediated inactivation of FOXO1A", "R-HSA-165160:r:PDE3B signalling", "R-DDI-1489509:r:DAG and IP3 signaling", "R-HSA-165158:r:Activation of AKT2", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-444257:r:RSK activation", "R-CEL-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-442742:r:CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DME-9009391:r:Extra-nuclear estrogen signaling"], "type": "Domain"}, "IPR017893": {"description": "DBB domain", "go_ids": [], "go_terms": [], "name": "DBB_domain", "pathway_ids": ["R-GGA-983695", "R-HSA-983695", "R-MMU-6811558", "R-GGA-6811558", "R-HSA-2219530", "R-HSA-1257604", "R-MMU-1257604", "R-MMU-983695", "R-GGA-1257604", "R-HSA-6811558"], "pathways": ["R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "type": "Domain"}, "IPR017896": {"description": "4Fe-4S ferredoxin-type, iron-sulphur binding domain", "go_ids": [], "go_terms": [], "name": "4Fe4S_Fe-S-bd", "pathway_ids": ["R-DDI-73621", "R-HSA-6799198", "R-DME-6799198", "R-SPO-9954714", "R-RNO-73621", "R-DRE-9854311", "R-GGA-372987", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-MMU-71403", "R-MMU-611105", "R-SPO-611105", "R-DDI-71403", "R-MMU-909733", "R-RNO-71403", "R-BTA-6799198", "R-CEL-73621", "R-MMU-8983711", "R-HSA-71403", "R-HSA-8983711", "R-HSA-9854311", "R-MMU-9954714", "R-MMU-6799198", "R-HSA-73621", "R-SCE-9954714", "R-MTU-936721", "R-DRE-71403", "R-DME-611105", "R-HSA-9954714", "R-RNO-611105", "R-HSA-611105", "R-RNO-9854311", "R-CEL-6799198", "R-DME-9954714", "R-HSA-909733", "R-SCE-71403", "R-CEL-611105", "R-XTR-9854311", "R-DME-71403", "R-SCE-611105", "R-DRE-73621", "R-MMU-73621", "R-XTR-71403", "R-SSC-611105", "R-BTA-611105"], "pathways": ["R-DDI-73621:r:Pyrimidine catabolism", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-73621:r:Pyrimidine catabolism", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-6799198:r:Complex I biogenesis", "R-CEL-73621:r:Pyrimidine catabolism", "R-MMU-8983711:r:OAS antiviral response", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-73621:r:Pyrimidine catabolism", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-DME-611105:r:Respiratory electron transport", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-6799198:r:Complex I biogenesis", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-611105:r:Respiratory electron transport", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-611105:r:Respiratory electron transport", "R-DRE-73621:r:Pyrimidine catabolism", "R-MMU-73621:r:Pyrimidine catabolism", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR017904": {"description": "ADF/Cofilin", "go_ids": ["GO:0015629", "GO:0030042"], "go_terms": ["GO:0015629:actin cytoskeleton:C", "GO:0030042:actin filament depolymerization:P"], "name": "ADF/Cofilin", "pathway_ids": ["R-HSA-114608", "R-HSA-8950505", "R-HSA-2029482", "R-HSA-399954", "R-HSA-3928662", "R-HSA-5627117"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Family"}, "IPR017905": {"description": "ERV/ALR sulfhydryl oxidase domain", "go_ids": ["GO:0016972"], "go_terms": ["GO:0016972:thiol oxidase activity:F"], "name": "ERV/ALR_sulphydryl_oxidase", "pathway_ids": ["PWY-7533", "R-RNO-381426", "R-HSA-6798695", "R-HSA-114608", "R-RNO-8957275", "R-HSA-1268020", "R-MMU-381426", "R-MMU-6798695", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR017913": {"description": "Colipase, N-terminal", "go_ids": ["GO:0005576", "GO:0007586", "GO:0008047", "GO:0016042"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0007586:digestion:P", "GO:0008047:enzyme activator activity:F", "GO:0016042:lipid catabolic process:P"], "name": "Colipase_N", "pathway_ids": ["R-MMU-975634", "R-SSC-975634", "R-BTA-192456", "R-RNO-192456", "R-HSA-192456", "R-RNO-975634", "R-XTR-192456", "R-MMU-192456", "R-XTR-975634", "R-BTA-975634", "R-HSA-975634", "R-SSC-192456"], "pathways": ["R-MMU-975634:r:Retinoid metabolism and transport", "R-SSC-975634:r:Retinoid metabolism and transport", "R-BTA-192456:r:Digestion of dietary lipid", "R-RNO-192456:r:Digestion of dietary lipid", "R-HSA-192456:r:Digestion of dietary lipid", "R-RNO-975634:r:Retinoid metabolism and transport", "R-XTR-192456:r:Digestion of dietary lipid", "R-MMU-192456:r:Digestion of dietary lipid", "R-XTR-975634:r:Retinoid metabolism and transport", "R-BTA-975634:r:Retinoid metabolism and transport", "R-HSA-975634:r:Retinoid metabolism and transport", "R-SSC-192456:r:Digestion of dietary lipid"], "type": "Domain"}, "IPR017914": {"description": "Colipase, C-terminal", "go_ids": ["GO:0005576", "GO:0007586", "GO:0008047", "GO:0016042"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0007586:digestion:P", "GO:0008047:enzyme activator activity:F", "GO:0016042:lipid catabolic process:P"], "name": "Colipase_C", "pathway_ids": ["R-MMU-975634", "R-SSC-975634", "R-BTA-192456", "R-RNO-192456", "R-HSA-192456", "R-RNO-975634", "R-XTR-192456", "R-MMU-192456", "R-XTR-975634", "R-BTA-975634", "R-HSA-975634", "R-SSC-192456"], "pathways": ["R-MMU-975634:r:Retinoid metabolism and transport", "R-SSC-975634:r:Retinoid metabolism and transport", "R-BTA-192456:r:Digestion of dietary lipid", "R-RNO-192456:r:Digestion of dietary lipid", "R-HSA-192456:r:Digestion of dietary lipid", "R-RNO-975634:r:Retinoid metabolism and transport", "R-XTR-192456:r:Digestion of dietary lipid", "R-MMU-192456:r:Digestion of dietary lipid", "R-XTR-975634:r:Retinoid metabolism and transport", "R-BTA-975634:r:Retinoid metabolism and transport", "R-HSA-975634:r:Retinoid metabolism and transport", "R-SSC-192456:r:Digestion of dietary lipid"], "type": "Domain"}, "IPR017916": {"description": "Steadiness box (SB) domain", "go_ids": [], "go_terms": [], "name": "SB_dom", "pathway_ids": ["R-RNO-917729", "R-HSA-917729", "R-HSA-9610379", "R-MMU-917729", "R-HSA-9918476", "R-HSA-174490", "R-HSA-9615710", "R-DDI-917729", "R-HSA-162588"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-9615710:r:Late endosomal microautophagy", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion"], "type": "Domain"}, "IPR017920": {"description": "COMM domain", "go_ids": [], "go_terms": [], "name": "COMM", "pathway_ids": ["R-MMU-8951664", "R-DDI-6798695", "R-BTA-8951664", "R-HSA-6798695", "R-RNO-8951664", "R-HSA-8951664", "R-DME-8951664", "R-MMU-6798695", "R-XTR-8951664", "R-RNO-6798695", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-XTR-8951664:r:Neddylation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-8951664:r:Neddylation"], "type": "Domain"}, "IPR017923": {"description": "Transcription factor IIS, N-terminal", "go_ids": [], "go_terms": [], "name": "TFIIS_N", "pathway_ids": ["R-RNO-6781823", "R-HSA-1989781", "R-HSA-167238", "R-RNO-674695", "R-DME-6781823", "R-DDI-6782210", "R-DME-75955", "R-HSA-6796648", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-SPO-6796648", "R-DME-6782135", "R-HSA-212436", "R-RNO-6782210", "R-BTA-75955", "R-XTR-674695", "R-DME-674695", "R-BTA-6782135", "R-DDI-6781823", "R-XTR-112382", "R-CEL-6782210", "R-MMU-674695", "R-CEL-6781823", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-RNO-112382", "R-CEL-112382", "R-CEL-6782135", "R-BTA-6782210", "R-MMU-6782210", "R-CEL-6796648", "R-SCE-6782135", "R-DDI-6782135", "R-HSA-6781827", "R-MMU-6782135", "R-DME-6796648", "R-MMU-6781823", "R-BTA-6781823", "R-HSA-167152", "R-DDI-6796648", "R-HSA-6782210", "R-HSA-9833110", "R-SCE-6782210", "R-BTA-6796648", "R-SCE-6796648", "R-CEL-75955", "R-MMU-6796648", "R-HSA-9770562", "R-HSA-167243", "R-RNO-6796648", "R-RNO-75955", "R-RNO-6782135", "R-HSA-381340", "R-HSA-6782135", "R-BTA-674695", "R-XTR-75955", "R-HSA-167290", "R-HSA-75955", "R-SPO-6782210", "R-DME-6782210", "R-HSA-674695", "R-SPO-6782135", "R-HSA-112382"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-212436:r:Generic Transcription Pathway", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9833110:r:RSV-host interactions", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR017924": {"description": "RNA-binding protein YhbY", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "RNA-binding_YhbY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR017926": {"description": "Glutamine amidotransferase", "go_ids": [], "go_terms": [], "name": "GATASE", "pathway_ids": ["R-MMU-500753", "R-MMU-9748787", "R-SPO-73817", "R-SCE-9748787", "R-HSA-500753", "R-DDI-9748787", "R-SCE-500753", "R-SPO-500753", "R-GGA-499943", "R-SCE-73817", "R-HSA-70635", "R-SCE-499943", "R-DDI-500753", "R-CEL-73817", "R-MMU-73817", "R-SPO-499943", "R-HSA-9955542", "R-HSA-499943", "R-PFA-73817", "R-RNO-70635", "R-MMU-499943", "R-MMU-70635", "R-DRE-499943", "R-DDI-73817", "R-CEL-9748787", "R-HSA-9748787", "R-DME-500753", "R-DME-499943", "R-BTA-499943", "R-CEL-500753", "R-RNO-73817", "R-SPO-9748787", "R-HSA-73817", "R-RNO-9748787", "R-PFA-9748787", "R-DDI-499943", "R-RNO-499943"], "pathways": ["R-MMU-500753:r:Pyrimidine biosynthesis", "R-MMU-9748787:r:Azathioprine ADME", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-9748787:r:Azathioprine ADME", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-DDI-9748787:r:Azathioprine ADME", "R-SCE-500753:r:Pyrimidine biosynthesis", "R-SPO-500753:r:Pyrimidine biosynthesis", "R-GGA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-70635:r:Urea cycle", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9955542:r:CPS1 variants cause CPS1 deficiency", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-70635:r:Urea cycle", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-70635:r:Urea cycle", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-9748787:r:Azathioprine ADME", "R-HSA-9748787:r:Azathioprine ADME", "R-DME-500753:r:Pyrimidine biosynthesis", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-9748787:r:Azathioprine ADME", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-9748787:r:Azathioprine ADME", "R-PFA-9748787:r:Azathioprine ADME", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Domain"}, "IPR017932": {"description": "Glutamine amidotransferase type 2 domain", "go_ids": [], "go_terms": [], "name": "GATase_2_dom", "pathway_ids": ["R-SCE-8963693", "R-HSA-381038", "R-SPO-8963693", "R-GGA-8963693", "R-RNO-8963693", "R-HSA-8963693", "R-SCE-446210", "R-MMU-73817", "R-SPO-446210", "R-HSA-446210", "R-HSA-9648895", "R-GGA-419140", "R-HSA-380994", "R-RNO-446210", "R-DME-73817", "R-MMU-446210", "R-MMU-8963693", "R-DDI-8963693", "R-RNO-73817", "R-HSA-4085023", "R-BTA-8963693", "R-HSA-73817", "R-HSA-9633012"], "pathways": ["R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-SPO-8963693:r:Aspartate and asparagine metabolism", "R-GGA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-SCE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-GGA-419140:r:De novo synthesis of IMP", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-RNO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-DDI-8963693:r:Aspartate and asparagine metabolism", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-4085023:r:Defective GFPT1 causes CMSTA1", "R-BTA-8963693:r:Aspartate and asparagine metabolism", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR017938": {"description": "Riboflavin synthase-like beta-barrel", "go_ids": [], "go_terms": [], "name": "Riboflavin_synthase-like_b-brl", "pathway_ids": ["R-CEL-156581", "R-RNO-9009391", "R-DDI-5578775", "R-MMU-9009391", "R-HSA-1614635", "R-HSA-1222449", "R-CFA-196836", "R-RNO-5218920", "R-HSA-203615", "R-RNO-3299685", "R-HSA-209968", "R-RNO-9033241", "R-BTA-4420097", "R-HSA-5218920", "R-CFA-211945", "R-HSA-196836", "R-DDI-5218920", "R-SCE-9033241", "R-SPO-1222556", "R-HSA-3359467", "R-DDI-9033241", "R-HSA-203641", "R-DDI-6798695", "R-SCE-1222556", "R-HSA-3299685", "R-HSA-9636249", "R-SSC-3299685", "R-SCE-1474151", "R-MMU-3299685", "R-MMU-156581", "R-HSA-211897", "R-SCE-5578775", "R-RNO-203615", "R-DME-5218920", "R-MMU-9013423", "R-RNO-211945", "R-HSA-203754", "R-SSC-9013149", "R-DME-203754", "R-MMU-209968", "R-RNO-6798695", "R-SSC-6798695", "R-HSA-211945", "R-HSA-1474151", "R-HSA-392154", "R-SSC-9013404", "R-DDI-9009391", "R-RNO-9759218", "R-RNO-196836", "R-SCE-392154", 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"R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-203615:r:eNOS activation", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-9033241:r:Peroxisomal protein import", "R-SSC-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-DME-209968:r:Thyroxine biosynthesis", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-DDI-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CFA-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-9033241:r:Peroxisomal protein import", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-196836:r:Vitamin C (ascorbate) metabolism", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-156581:r:Methylation", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-RNO-203754:r:NOSIP mediated eNOS trafficking", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DDI-203615:r:eNOS activation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-SCE-203615:r:eNOS activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-MMU-114608:r:Platelet degranulation", "R-CEL-209968:r:Thyroxine biosynthesis", "R-DDI-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SSC-209968:r:Thyroxine biosynthesis", "R-MMU-203615:r:eNOS activation", "R-BTA-211945:r:Phase I - Functionalization of compounds", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-114608:r:Platelet degranulation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-114608:r:Platelet degranulation", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5578775:r:Ion homeostasis", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-RNO-209968:r:Thyroxine biosynthesis", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-DME-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-5578775:r:Ion homeostasis", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-DME-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-SPO-203615:r:eNOS activation", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CFA-209968:r:Thyroxine biosynthesis", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-156581:r:Methylation", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Homologous_superfamily"}, "IPR017939": {"description": "Gamma-glutamylcyclotransferase", "go_ids": ["GO:0003839"], "go_terms": ["GO:0003839:gamma-glutamylcyclotransferase activity:F"], "name": "G-Glutamylcylcotransferase", "pathway_ids": ["PWY-4041", "PWY-7533", "R-HSA-174403", "R-BTA-174403", "R-MMU-174403"], "pathways": ["PWY-4041:t:gamma-glutamyl cycle", "PWY-7533:t:gliotoxin biosynthesis", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling"], "type": "Family"}, "IPR017941": {"description": "Rieske [2Fe-2S] iron-sulphur domain", "go_ids": ["GO:0051537"], "go_terms": ["GO:0051537:2 iron, 2 sulfur cluster binding:F"], "name": "Rieske_2Fe-2S", "pathway_ids": ["R-HSA-9865881", "R-DRE-9865881", "R-GGA-9865881", "R-SCE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SPO-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-MMU-611105", "R-RNO-9865881", "R-BTA-9865881", "R-SPO-611105", "R-SCE-611105", "R-SSC-9865881", "R-BTA-611105", "R-DME-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly", "R-DRE-9865881:r:Complex III assembly", "R-GGA-9865881:r:Complex III assembly", "R-SCE-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SPO-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-9865881:r:Complex III assembly", "R-BTA-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-SSC-9865881:r:Complex III assembly", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR017942": {"description": "Lipid-binding serum glycoprotein, N-terminal", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "Lipid-bd_serum_glycop_N", "pathway_ids": ["R-RNO-5686938", "R-HSA-6798695", "R-RNO-6803157", "R-BTA-6803157", "R-HSA-8964058", "R-MMU-166016", "R-HSA-166016", "R-BTA-6798695", "R-CEL-5686938", "R-HSA-6785807", "R-MMU-5686938", "R-HSA-8964041", "R-MMU-8957275", "R-MMU-166020", "R-BTA-166016", "R-HSA-381426", "R-HSA-166020", "R-MMU-381426", "R-HSA-6803157", "R-MMU-6798695", "R-CEL-166016", "R-MMU-6803157", "R-HSA-8957275", "R-HSA-5686938", "R-RNO-166016", "R-HSA-9029569", "R-MMU-8964058", "R-RNO-166020", "R-RNO-6798695"], "pathways": ["R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-6803157:r:Antimicrobial peptides", "R-HSA-8964058:r:HDL remodeling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-166020:r:Transfer of LPS from LBP carrier to CD14", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-166020:r:Transfer of LPS from LBP carrier to CD14", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-8964058:r:HDL remodeling", "R-RNO-166020:r:Transfer of LPS from LBP carrier to CD14", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR017943": {"description": "Bactericidal permeability-increasing protein, alpha/beta domain superfamily", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "Bactericidal_perm-incr_a/b_dom", "pathway_ids": ["R-RNO-5686938", "R-HSA-6798695", "R-DDI-6798695", "R-RNO-6798695", "R-RNO-6803157", "R-BTA-6803157", "R-HSA-8964058", "R-DDI-166016", "R-HSA-166016", "R-MMU-166016", "R-BTA-6798695", "R-CEL-5686938", "R-HSA-6785807", "R-MMU-5686938", "R-HSA-8964041", "R-MMU-8957275", "R-MMU-166020", "R-BTA-166016", "R-HSA-381426", "R-HSA-166020", "R-MMU-381426", "R-HSA-6803157", "R-DDI-6803157", "R-MMU-6798695", "R-CEL-166016", "R-MMU-6803157", "R-HSA-8957275", "R-HSA-5686938", "R-RNO-166016", "R-HSA-9029569", "R-MMU-8964058", "R-RNO-166020", "R-DDI-5686938"], "pathways": ["R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-6803157:r:Antimicrobial peptides", "R-HSA-8964058:r:HDL remodeling", "R-DDI-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-166020:r:Transfer of LPS from LBP carrier to CD14", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-166020:r:Transfer of LPS from LBP carrier to CD14", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-DDI-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-8964058:r:HDL remodeling", "R-RNO-166020:r:Transfer of LPS from LBP carrier to CD14", "R-DDI-5686938:r:Regulation of TLR by endogenous ligand"], "type": "Homologous_superfamily"}, "IPR017944": {"description": "KaiA/RbsU helical domain superfamily", "go_ids": ["GO:0006468"], "go_terms": ["GO:0006468:protein phosphorylation:P"], "name": "KaiA/RbsU_helical_domain_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR017945": {"description": "DHBP synthase RibB-like alpha/beta domain superfamily", "go_ids": [], "go_terms": [], "name": "DHBP_synth_RibB-like_a/b_dom", "pathway_ids": ["R-MMU-6787450", "R-HSA-6787450", "R-RNO-6787450", "R-BTA-6787450"], "pathways": ["R-MMU-6787450:r:tRNA modification in the mitochondrion", "R-HSA-6787450:r:tRNA modification in the mitochondrion", "R-RNO-6787450:r:tRNA modification in the mitochondrion", "R-BTA-6787450:r:tRNA modification in the mitochondrion"], "type": "Homologous_superfamily"}, "IPR017946": {"description": "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily", "go_ids": ["GO:0006629", "GO:0008081"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0008081:phosphoric diester hydrolase activity:F"], "name": "PLC-like_Pdiesterase_TIM-brl", "pathway_ids": ["R-DDI-114604", "R-BTA-112043", "R-MMU-114604", "R-HSA-2871796", "R-MMU-4086398", "R-HSA-167021", "R-SCE-204005", "R-RNO-202433", "R-HSA-1489509", "R-DDI-416476", "R-MMU-210990", "R-CEL-5654219", "R-RNO-2871809", "R-MMU-5654221", "R-DDI-1855204", "R-MMU-201556", "R-RNO-210990", "R-HSA-8853659", "R-DME-1855204", "R-DDI-983695", "R-BTA-6814848", "R-RNO-416476", "R-DDI-399997", "R-MMU-186763", "R-HSA-114604", "R-RNO-212718", "R-HSA-9026527", "R-CEL-1855204", "R-HSA-434316", "R-MMU-112043", "R-HSA-983695", "R-HSA-2424491", "R-RNO-112043", "R-BTA-500657", "R-HSA-5637810", "R-CEL-112043", "R-MMU-5654219", "R-DME-112043", "R-RNO-5654228", "R-HSA-1855204", "R-MMU-399997", "R-DDI-202433", "R-HSA-1483152", "R-HSA-9664323", "R-HSA-9680350", "R-RNO-2871796", "R-MMU-5654227", "R-HSA-5655253", "R-HSA-6814848", "R-HSA-202433", "R-SCE-114604", "R-RNO-1169408", "R-HSA-2029485", "R-HSA-9665348", "R-CEL-5654227", "R-CEL-5607764", "R-RNO-399997", "R-MMU-9034793", "R-RNO-6814848", "R-HSA-500657", "R-BTA-4086398", "R-CEL-5654221", "R-DME-416476", "R-HSA-4086398", "R-MMU-5621480", "R-RNO-434316", "R-HSA-1483115", "R-HSA-5655291", "R-HSA-418217", "R-SCE-3295583", "R-HSA-5655332", "R-HSA-2871809", "R-DDI-112043", "R-BTA-399997", "R-HSA-9717207", "R-HSA-5654219", "R-MMU-212718", "R-HSA-201556", "R-RNO-983695", "R-HSA-9027277", "R-RNO-5654227", "R-RNO-5654219", "R-RNO-166016", "R-CEL-114604", "R-HSA-9725370", "R-SPO-202433", "R-MMU-416476", "R-MMU-5607764", "R-DRE-1855204", "R-HSA-166016", "R-RNO-5621480", "R-HSA-5654228", "R-SPO-1855204", "R-MMU-2871796", "R-RNO-2029485", "R-SCE-5607764", "R-CEL-5654228", "R-MMU-2029485", "R-RNO-9026527", "R-MMU-434316", "R-HSA-5621480", "R-HSA-9664565", "R-HSA-5655302", "R-HSA-5654221", "R-HSA-212718", "R-RNO-201556", "R-HSA-9665686", "R-SPO-5607764", "R-RNO-8853659", "R-MMU-166016", "R-HSA-9034793", "R-MMU-8853659", "R-BTA-416476", "R-HSA-5218921", "R-BTA-1855204", "R-CEL-212718", "R-MMU-418217", "R-HSA-418890", "R-CEL-186763", "R-SCE-1855204", "R-SCE-202433", "R-HSA-416476", "R-HSA-1251932", "R-HSA-1169408", "R-HSA-399997", "R-CEL-416476", "R-GGA-1855204", "R-HSA-210990", "R-HSA-112043", "R-HSA-1236382", "R-SPO-114604", "R-SCE-983168", "R-MMU-5654228", "R-MMU-1855204", "R-HSA-5607764", "R-MMU-5218921", "R-DDI-1169408", "R-MMU-202433", "R-CEL-202433", "R-RNO-9034793", "R-MMU-500657", "R-BTA-434316", "R-MMU-6814848", "R-SSC-1855204", "R-HSA-9679191", "R-MMU-983695", "R-MMU-1169408", "R-RNO-5654221", "R-HSA-186763", "R-HSA-5654227", "R-RNO-114604", "R-RNO-5218921", "R-CEL-1169408", "R-RNO-2424491", "R-RNO-5607764", "R-MMU-2871809", "R-DDI-434316", "R-DDI-5607764", "R-RNO-1855204", "R-MMU-2424491", "R-BTA-418217", "R-RNO-186763", "R-MMU-9026527"], "pathways": ["R-DDI-114604:r:GPVI-mediated activation cascade", "R-BTA-112043:r:PLC beta mediated events", "R-MMU-114604:r:GPVI-mediated activation cascade", 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archaeal-type", "go_ids": ["GO:0019478", "GO:0016788", "GO:0051499"], "go_terms": ["GO:0019478:D-amino acid catabolic process:P", "GO:0016788:hydrolase activity, acting on ester bonds:F", "GO:0051499:D-aminoacyl-tRNA deacylase activity:F"], "name": "Deacylase_DtdA_arch-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018034": {"description": "KRR1 interacting protein 1", "go_ids": [], "go_terms": [], "name": "Kri1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018035": {"description": "Flagellar assembly protein FliH/Type III secretion system HrpE", "go_ids": [], "go_terms": [], "name": "Flagellar_FliH/T3SS_HrpE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018036": {"description": "Protein of unknown function DUF429, subgroup", "go_ids": [], "go_terms": [], "name": "DUF429_subgr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018037": {"description": "Nitrogen fixation protein FixH, Proteobacterial", "go_ids": [], "go_terms": [], "name": "FixH_proteobacterial", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018044": {"description": "Peptidase S11, D-alanyl-D-alanine carboxypeptidase A", "go_ids": ["GO:0006508", "GO:0009002"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0009002:serine-type D-Ala-D-Ala carboxypeptidase activity:F"], "name": "Peptidase_S11", "pathway_ids": ["PWY-6471", "PWY-5265"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)"], "type": "Family"}, "IPR018060": {"description": "AraC-like, DNA binding HTH domain", "go_ids": ["GO:0003700", "GO:0006355", "GO:0043565"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0043565:sequence-specific DNA binding:F"], "name": "HTH_AraC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018061": {"description": "Retropepsins", "go_ids": [], "go_terms": [], "name": "Retropepsins", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-164843", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164525", "R-HSA-173107", "R-HSA-162594"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Domain"}, "IPR018075": {"description": "Ubiquitin-activating enzyme E1", "go_ids": [], "go_terms": [], "name": "UBQ-activ_enz_E1", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-MMU-9909505", "R-HSA-168928", "R-DDI-936440", "R-HSA-9918485", "R-MMU-5656169", "R-RNO-8866652", "R-HSA-936440", "R-HSA-983168", "R-HSA-1169408", "R-MMU-8866652", "R-MMU-1169408", "R-HSA-9909505", "R-DDI-983168", "R-HSA-8866652", "R-DDI-9909505", "R-BTA-8866652", "R-MMU-983168", "R-SPO-983168", "R-RNO-983168", "R-SCE-983168", "R-HSA-5656169", "R-DDI-1169408", "R-DDI-8866652"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "type": "Family"}, "IPR018076": {"description": "Type II secretion system protein GspF domain", "go_ids": [], "go_terms": [], "name": "T2SS_GspF_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018077": {"description": "Glycoside hydrolase, family 25 subgroup", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_fam25_subgr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018081": {"description": "Anaphylatoxin, complement system", "go_ids": [], "go_terms": [], "name": "Anaphylatoxin_comp_syst", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-418594", "R-RNO-977606", "R-BTA-8957275", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors"], "type": "Homologous_superfamily"}, "IPR018090": {"description": "Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic", "go_ids": ["GO:0016154", "GO:0006213"], "go_terms": ["GO:0016154:pyrimidine-nucleoside phosphorylase activity:F", "GO:0006213:pyrimidine nucleoside metabolic process:P"], "name": "Pyrmidine_PPas_bac/euk", "pathway_ids": ["PWY-7181", "R-RNO-73621", "R-MMU-73614", "R-HSA-73621", "R-HSA-73614", "R-MMU-73621", "R-RNO-73614"], "pathways": ["PWY-7181:t:pyrimidine deoxyribonucleosides degradation", "R-RNO-73621:r:Pyrimidine catabolism", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-73614:r:Pyrimidine salvage"], "type": "Family"}, "IPR018094": {"description": "Thymidylate kinase", "go_ids": ["GO:0004798", "GO:0005524", "GO:0006233"], "go_terms": ["GO:0004798:dTMP kinase activity:F", "GO:0005524:ATP binding:F", "GO:0006233:dTDP biosynthetic process:P"], "name": "Thymidylate_kinase", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7184", "PWY-7187", "PWY-7210", "PWY-7197", "R-HSA-499943", "R-DRE-499943", "R-MMU-499943"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7197:t:pyrimidine deoxyribonucleotide phosphorylation", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR018105": {"description": "Translationally controlled tumour protein", "go_ids": [], "go_terms": [], "name": "Translational_control_tumour_p", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018108": {"description": "Mitochondrial carrier protein, transmembrane region", "go_ids": [], "go_terms": [], "name": "MCP_transmembrane", "pathway_ids": ["R-HSA-1362409", "R-RNO-83936", "R-HSA-389599", "R-HSA-9856872", "R-HSA-167826", "R-SSC-1268020", "R-HSA-442660", "R-DDI-9603798", "R-RNO-166187", "R-SCE-1614517", "R-CEL-1614517", "R-DDI-71064", "R-BTA-428643", "R-DDI-70635", "R-MMU-199220", "R-CEL-200425", "R-MMU-389599", "R-DRE-549127", "R-DDI-196819", "R-MMU-166187", "R-SCE-166187", "R-HSA-9844594", "R-HSA-1268020", "R-MMU-196757", "R-BTA-9837999", "R-HSA-71064", "R-DME-9856872", "R-SPO-199220", "R-DDI-199220", "R-SSC-428643", "R-SCE-83936", "R-MMU-9603798", "R-SCE-1268020", "R-SCE-442660", "R-SCE-200425", "R-RNO-167826", "R-BTA-9856872", "R-SCE-8963693", "R-SPO-70635", "R-DDI-389599", "R-MMU-200425", "R-SCE-199220", "R-DDI-83936", "R-RNO-8963693", "R-HSA-8963693", "R-HSA-196807", "R-HSA-70895", "R-HSA-9956508", "R-SPO-1268020", "R-HSA-196819", "R-RNO-196807", "R-CEL-9856872", "R-SCE-9856872", "R-HSA-196757", "R-RNO-196819", "R-MMU-70635", "R-RNO-1614517", "R-BTA-442660", "R-DDI-428643", "R-SSC-9856872", "R-HSA-166187", "R-MMU-8963693", "R-DDI-8963693", "R-HSA-549127", "R-BTA-83936", "R-HSA-168277", "R-BTA-196819", "R-DDI-196757", "R-HSA-180897", "R-DME-1268020", "R-DME-167826", "R-DDI-166187", "R-MMU-196807", "R-MMU-9837999", "R-MMU-549127", "R-DME-200425", "R-DME-549127", "R-SSC-83936", "R-HSA-1614517", "R-BTA-549127", "R-HSA-199220", "R-SCE-196819", "R-MMU-83936", "R-RNO-199220", "R-HSA-428643", "R-SCE-428643", "R-BTA-352230", "R-DME-83936", "R-XTR-549127", "R-RNO-442660", "R-DDI-9856872", "R-RNO-352230", "R-MMU-352230", "R-SPO-196819", "R-HSA-352230", "R-DME-8963693", "R-MMU-442660", "R-MMU-167826", "R-BTA-1268020", "R-DRE-428643", "R-RNO-200425", "R-DRE-167826", "R-HSA-9837999", "R-RNO-428643", "R-XTR-199220", "R-BTA-71064", "R-SSC-167826", "R-HSA-9603798", "R-CEL-8963693", "R-MMU-1614517", "R-DRE-199220", "R-MMU-428643", "R-SPO-352230", "R-DDI-9837999", "R-CEL-428643", "R-MMU-71064", "R-DDI-1268020", "R-HSA-83936", "R-SPO-549127", "R-DME-9837999", "R-DDI-1614517", "R-HSA-70635", "R-RNO-9837999", "R-BTA-166187", "R-RNO-70635", "R-RNO-71064", "R-BTA-167826", "R-MMU-196819", "R-DDI-442660", "R-HSA-200425", "R-SPO-9837999", "R-SPO-166187", "R-SCE-9837999", "R-MMU-9856872", "R-SSC-9837999", "R-RNO-9856872", "R-SPO-428643", "R-SCE-196757", "R-SCE-549127", "R-SPO-196757", "R-SCE-70635", "R-SPO-83936"], "pathways": ["R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-HSA-9856872:r:Malate-aspartate shuttle", "R-HSA-167826:r:The fatty acid cycling model", "R-SSC-1268020:r:Mitochondrial protein import", "R-HSA-442660:r:SLC-mediated transport of neurotransmitters", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-166187:r:Mitochondrial Uncoupling", "R-SCE-1614517:r:Sulfide oxidation to sulfate", "R-CEL-1614517:r:Sulfide oxidation to sulfate", "R-DDI-71064:r:Lysine catabolism", "R-BTA-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-DDI-70635:r:Urea cycle", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-CEL-200425:r:Carnitine shuttle", "R-MMU-389599:r:Alpha-oxidation of phytanate", "R-DRE-549127:r:SLC-mediated transport of organic cations", "R-DDI-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-166187:r:Mitochondrial Uncoupling", "R-SCE-166187:r:Mitochondrial Uncoupling", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-196757:r:Metabolism of folate and pterines", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-71064:r:Lysine catabolism", "R-DME-9856872:r:Malate-aspartate shuttle", "R-SPO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SSC-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SCE-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-1268020:r:Mitochondrial protein import", "R-SCE-442660:r:SLC-mediated transport of neurotransmitters", "R-SCE-200425:r:Carnitine shuttle", "R-RNO-167826:r:The fatty acid cycling model", "R-BTA-9856872:r:Malate-aspartate shuttle", "R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-SPO-70635:r:Urea cycle", "R-DDI-389599:r:Alpha-oxidation of phytanate", "R-MMU-200425:r:Carnitine shuttle", "R-SCE-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DDI-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9956508:r:SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome", "R-SPO-1268020:r:Mitochondrial protein import", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-SCE-9856872:r:Malate-aspartate shuttle", "R-HSA-196757:r:Metabolism of folate and pterines", "R-RNO-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-70635:r:Urea cycle", "R-RNO-1614517:r:Sulfide oxidation to sulfate", "R-BTA-442660:r:SLC-mediated transport of neurotransmitters", "R-DDI-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SSC-9856872:r:Malate-aspartate shuttle", "R-HSA-166187:r:Mitochondrial Uncoupling", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-DDI-8963693:r:Aspartate and asparagine metabolism", "R-HSA-549127:r:SLC-mediated transport of organic cations", "R-BTA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-168277:r:Influenza Virus Induced Apoptosis", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism", "R-DDI-196757:r:Metabolism of folate and pterines", "R-HSA-180897:r:Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "R-DME-1268020:r:Mitochondrial protein import", "R-DME-167826:r:The fatty acid cycling model", "R-DDI-166187:r:Mitochondrial Uncoupling", "R-MMU-196807:r:Nicotinate metabolism", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-DME-200425:r:Carnitine shuttle", "R-DME-549127:r:SLC-mediated transport of organic cations", "R-SSC-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-1614517:r:Sulfide oxidation to sulfate", "R-BTA-549127:r:SLC-mediated transport of organic cations", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SCE-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SCE-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-BTA-352230:r:Amino acid transport across the plasma membrane", "R-DME-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-XTR-549127:r:SLC-mediated transport of organic cations", "R-RNO-442660:r:SLC-mediated transport of neurotransmitters", 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"R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-DRE-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SPO-352230:r:Amino acid transport across the plasma membrane", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-CEL-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-MMU-71064:r:Lysine catabolism", "R-DDI-1268020:r:Mitochondrial protein import", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-SPO-549127:r:SLC-mediated transport of organic cations", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DDI-1614517:r:Sulfide oxidation to sulfate", "R-HSA-70635:r:Urea cycle", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-166187:r:Mitochondrial Uncoupling", "R-RNO-70635:r:Urea cycle", "R-RNO-71064:r:Lysine catabolism", "R-BTA-167826:r:The fatty acid cycling model", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism", "R-DDI-442660:r:SLC-mediated transport of neurotransmitters", "R-HSA-200425:r:Carnitine shuttle", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SPO-166187:r:Mitochondrial Uncoupling", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-SPO-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SCE-549127:r:SLC-mediated transport of organic cations", "R-SPO-196757:r:Metabolism of folate and pterines", "R-SCE-70635:r:Urea cycle", "R-SPO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "type": "Repeat"}, "IPR018113": {"description": "Phosphotransferase system EIIB, cysteine phosphorylation site", "go_ids": ["GO:0008982"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F"], "name": "PTrfase_EIIB_Cys", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR018119": {"description": "Strictosidine synthase, conserved region", "go_ids": [], "go_terms": [], "name": "Strictosidine_synth_cons-reg", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018121": {"description": "Seven-in-absentia protein, TRAF-like domain", "go_ids": ["GO:0005737", "GO:0006511", "GO:0007275"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006511:ubiquitin-dependent protein catabolic process:P", "GO:0007275:multicellular organism development:P"], "name": "7-in-absentia-prot_TRAF-dom", "pathway_ids": ["PWY-7511", "R-CEL-5689880", "R-MMU-5689880", "R-DME-983168", "R-DRE-5689880", "R-HSA-5689880", "R-HSA-977225", "R-MMU-983168", "R-RNO-983168", "R-HSA-983168", "R-HSA-373752", "R-CEL-983168", "R-DME-5689880", "R-RNO-5689880", "R-DRE-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-373752:r:Netrin-1 signaling", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-5689880:r:Ub-specific processing proteases", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR018123": {"description": "WWE domain, subgroup", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "WWE-dom_subgr", "pathway_ids": ["PWY-7511", "R-RNO-201681", "R-DME-2122948", "R-BTA-8948751", "R-HSA-201681", "R-HSA-3270619", "R-RNO-8948751", "R-MMU-3270619", "R-DRE-8948751", "R-HSA-1606341", "R-HSA-2122948", "R-BTA-5689880", "R-HSA-5689880", "R-MMU-3134975", "R-MMU-2122948", "R-MMU-201681", "R-HSA-983168", "R-BTA-201681", "R-XTR-8948751", "R-MMU-8948751", "R-RNO-5689880", "R-MMU-5689880", "R-RNO-4641257", "R-MMU-4641257", "R-HSA-4641257", "R-HSA-3134975", "R-MMU-983168", "R-HSA-8948751", "R-BTA-4641257", "R-RNO-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-XTR-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-4641257:r:Degradation of AXIN", "R-MMU-4641257:r:Degradation of AXIN", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-4641257:r:Degradation of AXIN", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR018131": {"description": "Restriction endonuclease, type II, EcoRI, Proteobacteria", "go_ids": ["GO:0000287", "GO:0003677", "GO:0009036", "GO:0009307"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0003677:DNA binding:F", "GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_II_EcoRI_Pbac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018141": {"description": "Nitrile hydratase, alpha subunit", "go_ids": ["GO:0018822", "GO:0046914"], "go_terms": ["GO:0018822:nitrile hydratase activity:F", 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signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-SSC-418594:r:G alpha (i) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Domain"}, "IPR018143": {"description": "Folate receptor-like", "go_ids": [], "go_terms": [], "name": "Folate_rcpt-like", "pathway_ids": ["R-HSA-204005", "R-HSA-6798695", "R-MMU-204005", "R-MMU-163125", "R-MMU-5632681", "R-HSA-5632681", "R-MMU-196757", "R-MMU-5694530", "R-HSA-6807878", "R-MMU-6798695", "R-MMU-6807878", "R-HSA-196757", "R-HSA-5694530", "R-RNO-163125", "R-HSA-163125"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-5632681:r:Ligand-receptor 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"R-HSA-193634", "R-HSA-8856825", "R-MMU-264870", "R-HSA-446388", "R-DRE-193648", "R-MMU-9696273", "R-MMU-9013149", "R-MMU-6805567", "R-DME-9013420", "R-MMU-416476", "R-HSA-6798695", "R-GGA-9035034", "R-DME-375165", "R-MMU-9013106", "R-HSA-8856828", "R-RNO-9013149", "R-HSA-9013424", "R-HSA-351906", "R-MMU-9013404", "R-MMU-446388", "R-CEL-5673001", "R-HSA-3928662", "R-BTA-9035034", "R-DME-9035034", "R-RNO-9013424", "R-DRE-6798695", "R-DME-264870", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-BTA-9013418", "R-DME-6807878", "R-RNO-5673001", "R-DME-438066", "R-HSA-373753", "R-DME-445095", "R-DRE-6805567", "R-MMU-438066", "R-MMU-390522", "R-RNO-9696273", "R-GGA-9013418", "R-BTA-390522", "R-RNO-418885", "R-HSA-5673001", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-6809371", "R-MMU-9913351", "R-MMU-445095", "R-DME-446388", "R-HSA-9620244", "R-DRE-351906", "R-MMU-6798695", "R-DRE-416482", "R-MMU-375165", "R-MMU-114608", "R-DRE-9013423", "R-CEL-375165", "R-HSA-2132295", "R-HSA-6809371", "R-DRE-9696273", "R-HSA-9619665", "R-MMU-9013148", "R-HSA-416476", "R-HSA-418885", "R-MMU-6807878", "R-DME-9013424", "R-HSA-375165", "R-HSA-1221632", "R-RNO-114608", "R-BTA-114608", "R-HSA-9035034", "R-DRE-9013149", "R-RNO-9013106", "R-HSA-9617324", "R-HSA-193648", "R-RNO-6809371", "R-HSA-9013420", "R-DRE-9013408", "R-RNO-390522", "R-CEL-9913351", "R-RNO-6807878", "R-HSA-9662361", "R-HSA-6807878", "R-DME-9013418", "R-RNO-9913351", "R-HSA-9703465", "R-DRE-9013148", "R-HSA-5687128", "R-HSA-438066", "R-DDI-6807878", "R-MMU-9013026", "R-MMU-416482", "R-MMU-3928662", "R-HSA-390522", "R-RNO-264870", "R-DRE-416476", "R-MMU-9696270", "R-HSA-9696273", "R-MMU-418885"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-DDI-114608:r:Platelet degranulation", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-RNO-6805567:r:Keratinization", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-DME-114608:r:Platelet degranulation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-193648:r:NRAGE signals death through JNK", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-114608:r:Platelet degranulation", "R-DRE-9696264:r:RND3 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-HSA-6805567:r:Keratinization", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-DRE-6809371:r:Formation of the cornified envelope", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9013424:r:RHOV GTPase cycle", "R-BTA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-GGA-114608:r:Platelet degranulation", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-6805567:r:Keratinization", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-9035034:r:RHOF GTPase cycle", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-BTA-9035034:r:RHOF GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-373753:r:Nephrin family interactions", "R-DME-445095:r:Interaction between L1 and Ankyrins", "R-DRE-6805567:r:Keratinization", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-390522:r:Striated Muscle Contraction", "R-RNO-9696273:r:RND1 GTPase cycle", "R-GGA-9013418:r:RHOBTB2 GTPase cycle", "R-BTA-390522:r:Striated Muscle Contraction", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-9620244:r:Long-term potentiation", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-MMU-114608:r:Platelet degranulation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-DRE-9696273:r:RND1 GTPase cycle", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1221632:r:Meiotic synapsis", "R-RNO-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DRE-9013408:r:RHOG GTPase cycle", "R-RNO-390522:r:Striated Muscle Contraction", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-DRE-416476:r:G alpha (q) signalling events", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Repeat"}, "IPR018162": {"description": "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily", "go_ids": ["GO:0000166", "GO:0004813", "GO:0005524", "GO:0005737", "GO:0006419"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004813:alanine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006419:alanyl-tRNA aminoacylation:P"], "name": "Ala-tRNA-ligase_IIc_anticod-bd", "pathway_ids": ["R-HSA-379716", "R-HSA-379726"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR018163": {"description": "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily", "go_ids": ["GO:0000166"], "go_terms": ["GO:0000166:nucleotide binding:F"], "name": "Thr/Ala-tRNA-synth_IIc_edit", "pathway_ids": ["R-HSA-379726", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-HSA-379716", "R-DME-9937383"], "pathways": ["R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Homologous_superfamily"}, "IPR018164": {"description": "Alanyl-tRNA synthetase, class IIc, N-terminal", "go_ids": ["GO:0000166", "GO:0004813", "GO:0005524", "GO:0006419"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004813:alanine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0006419:alanyl-tRNA aminoacylation:P"], "name": "Ala-tRNA-synth_IIc_N", "pathway_ids": ["R-HSA-379716", "R-HSA-379726"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Domain"}, "IPR018184": {"description": "Integrin alpha chain, C-terminal cytoplasmic region, conserved site", "go_ids": [], "go_terms": [], "name": "Integrin_alpha_C_CS", "pathway_ids": ["R-DME-2173789", "R-HSA-6798695", "R-HSA-8874081", "R-HSA-5674135", "R-MMU-210991", "R-HSA-6802952", "R-HSA-3000178", "R-HSA-8936459", "R-DME-198933", "R-HSA-166016", "R-CEL-354194", "R-CEL-6798695", "R-MMU-210990", "R-BTA-6798695", "R-CEL-3000178", "R-HSA-9856532", "R-CEL-1566948", "R-MMU-4420097", "R-DME-445355", "R-HSA-9927418", "R-MMU-445355", "R-RNO-3000157", "R-MMU-3000170", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-CEL-202733", "R-MMU-202733", "R-HSA-9926550", "R-CEL-198933", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-446107", "R-HSA-6802955", "R-HSA-210991", "R-BTA-9634597", "R-HSA-2173789", "R-RNO-3000178", "R-CEL-216083", "R-BTA-198933", "R-HSA-6802948", "R-DME-210991", "R-CEL-9860927", "R-CEL-1236973", "R-MMU-166016", "R-BTA-1566948", "R-DME-114608", "R-MMU-9634597", "R-HSA-8949275", "R-CEL-114608", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-CEL-5674135", "R-DME-354192", "R-HSA-8941332", "R-HSA-447041", "R-DME-216083", "R-HSA-75892", "R-DME-445144", "R-MMU-198933", "R-HSA-2022090", "R-MMU-216083", "R-MMU-6798695", "R-HSA-445144", "R-HSA-198933", "R-HSA-9860927", "R-HSA-372708", "R-MMU-354192", "R-MMU-9860927", "R-MMU-446107", "R-HSA-9656223", "R-MMU-114608", "R-HSA-9634597", "R-MMU-5674135", "R-RNO-216083", "R-HSA-9725554", "R-HSA-9927426", "R-HSA-3000157", "R-BTA-1566977", "R-CEL-1566977", "R-HSA-1566948", "R-DME-9860927", "R-BTA-202733", "R-MMU-372708", "R-HSA-210990", "R-HSA-114608", "R-DME-1236973", "R-MMU-8874081", "R-RNO-445355", "R-HSA-416700", "R-HSA-6802946", "R-CEL-354192", "R-DME-2129379", "R-HSA-9938206", "R-HSA-354192", "R-MMU-3000157", "R-BTA-8874081", "R-MMU-2173789", "R-DME-202733", "R-HSA-2129379", "R-HSA-3000170", "R-HSA-216083", "R-MMU-1566977", "R-DME-6798695", "R-CEL-210991", "R-HSA-1566977", "R-CEL-445144", "R-HSA-445355", "R-HSA-9927432", "R-DME-446107", "R-HSA-354194", "R-HSA-9679191", "R-MMU-354194", "R-MMU-1236973", "R-HSA-9830674", "R-BTA-9860927", "R-DME-3000170", "R-CEL-4420097", "R-CEL-445355", "R-BTA-216083", "R-HSA-202733", "R-MMU-2129379"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-210990:r:PECAM1 interactions", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-CEL-1566948:r:Elastic fibre formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-445355:r:Smooth Muscle Contraction", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-445355:r:Smooth Muscle Contraction", "R-RNO-3000157:r:Laminin interactions", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-BTA-9634597:r:GPER1 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-3000178:r:ECM proteoglycans", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-210991:r:Basigin interactions", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-8949275:r:RUNX3 Regulates Immune Response and Cell Migration", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-DME-354192:r:Integrin signaling", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-HSA-447041:r:CHL1 interactions", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-445144:r:Signal transduction by L1", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory 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{"description": "5 transmembrane protein, Schizosaccharomyces pombe", "go_ids": [], "go_terms": [], "name": "5TM-prot_SCHPO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018292": {"description": "A-kinase anchor 110kDa, C-terminal", "go_ids": [], "go_terms": [], "name": "AKAP_110_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018302": {"description": "Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain", "go_ids": [], "go_terms": [], "name": "CenpF/LEK1_Rb-prot-bd", "pathway_ids": ["R-HSA-141444", "R-HSA-5663220", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-9648025", "R-HSA-68877", "R-HSA-156711"], "pathways": ["R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-68877:r:Mitotic 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"R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR018337": {"description": "Cell wall/choline-binding repeat", "go_ids": [], "go_terms": [], "name": "Cell_wall/Cho-bd_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR018379": {"description": "BEN domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "BEN_domain", "pathway_ids": ["R-DRE-6804759", "R-HSA-9766229", "R-DRE-9766229", "R-MMU-6804759", "R-MMU-9766229", "R-XTR-9766229", "R-XTR-6804759", "R-HSA-6804759"], "pathways": ["R-DRE-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-9766229:r:Degradation of CDH1", "R-DRE-9766229:r:Degradation of CDH1", "R-MMU-6804759:r:Regulation of TP53 Activity through 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["GO:0003677:DNA binding:F"], "name": "Tfx_DNA-bd_euryarc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018385": {"description": "C4-dicarboxylate anaerobic carrier-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "C4_dicarb_anaerob_car-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018389": {"description": "TRAP transporter solute receptor DctP", "go_ids": ["GO:0055085"], "go_terms": ["GO:0055085:transmembrane transport:P"], "name": "DctP_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018391": {"description": "Pyrrolo-quinoline quinone beta-propeller repeat", "go_ids": [], "go_terms": [], "name": "PQQ_b-propeller_rpt", "pathway_ids": ["R-DDI-381070", "R-DME-9833482", "R-HSA-381070", "R-CEL-1169408", "R-DME-381042", "R-SCE-381070", "R-HSA-9760173", "R-CEL-9833482", "R-CEL-381042", "R-MMU-381070", "R-CEL-381070", "R-SPO-381070"], "pathways": ["R-DDI-381070:r:IRE1alpha activates chaperones", 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"R-HSA-611105", "R-HSA-5419276", "R-RNO-5419276", "R-MMU-6799198", "R-HSA-6799198", "R-DRE-611105", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-RNO-6799198", "R-SSC-5419276", "R-HSA-9837999", "R-SSC-6799198", "R-SSC-611105", "R-DRE-5419276"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-RNO-6799198:r:Complex I biogenesis", "R-SSC-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SSC-6799198:r:Complex I biogenesis", "R-SSC-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR018395": {"description": "2-keto-3-deoxygluconate permease, subgroup", "go_ids": ["GO:0008643", "GO:0015649", "GO:0016020", "GO:0046411"], "go_terms": ["GO:0008643:carbohydrate transport:P", "GO:0015649:2-keto-3-deoxygluconate:proton symporter activity:F", "GO:0016020:membrane:C", "GO:0046411:2-keto-3-deoxygluconate transmembrane transport:P"], "name": "2keto-3dGluconate_permease_sub", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018396": {"description": "Lysosomal-associated transmembrane protein, 4A/5", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "LAPTM_4A/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018402": {"description": "Malonate/sodium symporter MadM subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "Mal/Na_symporter_MadM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018403": {"description": "Silicon transporter, 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"R-MMU-425986:r:Sodium/Proton exchangers", "R-RNO-425986:r:Sodium/Proton exchangers", "R-BTA-425986:r:Sodium/Proton exchangers", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-5619092:r:Defective SLC9A6 causes X-linked, syndromic mental retardation, Christianson type (MRXSCH)", "R-DDI-425986:r:Sodium/Proton exchangers", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-HSA-5619052:r:Defective SLC9A9 causes autism 16 (AUTS16)"], "type": "Family"}, "IPR018445": {"description": "Putative phosphate transport regulator", "go_ids": [], "go_terms": [], "name": "Put_Phosphate_transp_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018448": {"description": "Sec-independent protein translocase protein TatB", "go_ids": ["GO:0016020", "GO:0043953", "GO:0008320"], "go_terms": ["GO:0016020:membrane:C", "GO:0043953:protein transport by the Tat complex:P", "GO:0008320:transmembrane protein transporter 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"Family"}, "IPR018469": {"description": "Dual oxidase maturation factor", "go_ids": ["GO:0005789", "GO:0015031", "GO:0016020"], "go_terms": ["GO:0005789:endoplasmic reticulum membrane:C", "GO:0015031:protein transport:P", "GO:0016020:membrane:C"], "name": "Dual_oxidase_maturation_fac", "pathway_ids": ["R-HSA-209968", "R-MMU-209968", "R-XTR-209968", "R-CEL-209968"], "pathways": ["R-HSA-209968:r:Thyroxine biosynthesis", "R-MMU-209968:r:Thyroxine biosynthesis", "R-XTR-209968:r:Thyroxine biosynthesis", "R-CEL-209968:r:Thyroxine biosynthesis"], "type": "Family"}, "IPR018470": {"description": "Periplasmic metal-binding protein Tp34-type", "go_ids": [], "go_terms": [], "name": "Metal-bd_Tp34-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018472": {"description": "Large ribosomal subunit protein mL64", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "Ribosomal_mL64", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-RNO-5389840"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR018473": {"description": "Hermes trasposase, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "Hermes_transposase_DNA-db", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018474": {"description": "Uncharacterised protein family YqaI", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Yqai", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018475": {"description": "Luciferase, helical bundle domain", "go_ids": [], "go_terms": [], "name": "Luciferase_hlx-bundle_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018476": {"description": "Glycerophosphoryl diester phosphodiesterase, membrane domain", "go_ids": [], "go_terms": [], "name": "GlyceroP-diester-Pdiesterase_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018477": {"description": "Bicaudal-D protein", "go_ids": ["GO:0070840", "GO:0008093"], "go_terms": ["GO:0070840:dynein complex binding:F", "GO:0008093:cytoskeletal adaptor activity:F"], "name": "BICD", "pathway_ids": ["R-CEL-6811436", "R-DME-6811436", "R-HSA-6811436", "R-MMU-6811436"], "pathways": ["R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR018478": {"description": "Sporulation transcription regulator WhiA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Sporu_reg_WhiA_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018479": {"description": "Monopolin complex subunit Lrs4/Mde4", "go_ids": [], "go_terms": [], "name": "Lrs4/Mde4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018480": {"description": "Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site", "go_ids": [], "go_terms": [], "name": "PNAcMuramoyl-5peptid_Trfase_CS", "pathway_ids": ["PWY-6470", "PWY-6471", "PWY-5265", "PWY-6385"], "pathways": ["PWY-6470:t:peptidoglycan biosynthesis V (beta-lactam resistance)", "PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)"], "type": "Conserved_site"}, "IPR018482": {"description": "Zinc finger C4H2 domain-containing protein", "go_ids": [], "go_terms": [], "name": "Znf-C4H2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018484": {"description": "Carbohydrate kinase FGGY, N-terminal", "go_ids": ["GO:0016301", "GO:0005975"], "go_terms": ["GO:0016301:kinase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "FGGY_N", "pathway_ids": ["PWY-4261", "R-HSA-5661270", "R-MMU-71336", "R-HSA-71336", "R-RNO-5661270", "R-BTA-75109", "R-DDI-75109", "R-SCE-75109", "R-BTA-5661270", "R-MMU-75109", "R-CEL-75109", "R-HSA-75109", "R-MMU-5661270", "R-SCE-5661270", "R-RNO-75109", "R-CEL-5661270", "R-SPO-5661270"], "pathways": ["PWY-4261:t:glycerol degradation I", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-BTA-75109:r:Triglyceride biosynthesis", "R-DDI-75109:r:Triglyceride biosynthesis", "R-SCE-75109:r:Triglyceride biosynthesis", "R-BTA-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-75109:r:Triglyceride biosynthesis", "R-CEL-75109:r:Triglyceride biosynthesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-SCE-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-75109:r:Triglyceride biosynthesis", "R-CEL-5661270:r:Formation of xylulose-5-phosphate", "R-SPO-5661270:r:Formation of xylulose-5-phosphate"], "type": "Domain"}, "IPR018485": {"description": "Carbohydrate kinase FGGY, C-terminal", "go_ids": ["GO:0016301", "GO:0005975"], "go_terms": ["GO:0016301:kinase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "FGGY_C", "pathway_ids": ["R-MMU-75109", "R-CEL-75109", "R-HSA-75109", "R-MMU-5661270", "R-SCE-5661270", "R-RNO-75109", "R-CEL-5661270", "R-SPO-5661270", "PWY-4261", "R-HSA-5661270", "R-RNO-5661270", "R-BTA-75109", "R-DDI-75109", "R-SCE-75109", "R-BTA-5661270"], "pathways": ["R-MMU-75109:r:Triglyceride biosynthesis", "R-CEL-75109:r:Triglyceride biosynthesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-SCE-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-75109:r:Triglyceride biosynthesis", "R-CEL-5661270:r:Formation of xylulose-5-phosphate", "R-SPO-5661270:r:Formation of xylulose-5-phosphate", "PWY-4261:t:glycerol degradation I", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-BTA-75109:r:Triglyceride biosynthesis", "R-DDI-75109:r:Triglyceride biosynthesis", "R-SCE-75109:r:Triglyceride biosynthesis", "R-BTA-5661270:r:Formation of xylulose-5-phosphate"], "type": "Domain"}, "IPR018487": {"description": "Hemopexin-like repeats", "go_ids": [], "go_terms": [], "name": "Hemopexin-like_repeat", "pathway_ids": ["R-SSC-3000170", "R-CEL-1592389", "R-HSA-6798695", "R-RNO-2022090", "R-HSA-9920588", 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"R-CFA-1474228:r:Degradation of the extracellular matrix", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-BTA-1442490:r:Collagen degradation", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-SSC-2129379:r:Molecules associated with elastic fibres", "R-HSA-977606:r:Regulation of Complement cascade", "R-SSC-1442490:r:Collagen degradation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-GGA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-CFA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-977606:r:Regulation of Complement cascade", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-1442490:r:Collagen degradation", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-SSC-977606:r:Regulation of Complement cascade", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1442490:r:Collagen degradation", "R-CEL-1442490:r:Collagen degradation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1442490:r:Collagen degradation", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Repeat"}, "IPR018490": {"description": "Cyclic nucleotide-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "cNMP-bd_dom_sf", "pathway_ids": ["R-HSA-6814848", "R-PFA-5687128", "R-HSA-2672351", "R-BTA-163615", "R-DME-6814848", "R-DDI-442720", "R-MMU-380284", "R-MMU-418457", "R-BTA-983231", "R-HSA-5620916", "R-DME-392517", 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"R-HSA-5619104"], "pathways": ["R-RNO-426117:r:Cation-coupled Chloride cotransporters", "R-SCE-426117:r:Cation-coupled Chloride cotransporters", "R-HSA-426117:r:Cation-coupled Chloride cotransporters", "R-DRE-426117:r:Cation-coupled Chloride cotransporters", "R-HSA-5619087:r:Defective SLC12A3 causes Gitelman syndrome (GS)", "R-CEL-426117:r:Cation-coupled Chloride cotransporters", "R-MMU-426117:r:Cation-coupled Chloride cotransporters", "R-HSA-5619039:r:Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)", "R-HSA-5619104:r:Defective SLC12A1 causes Bartter syndrome 1 (BS1)"], "type": "Domain"}, "IPR018497": {"description": "Peptidase M13, C-terminal domain", "go_ids": ["GO:0004222", "GO:0006508"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_M13_C", "pathway_ids": ["R-HSA-5578768", "R-HSA-6798695", "R-MMU-5578768", "R-RNO-375276", "R-HSA-375276", "R-DME-6798695", "R-HSA-9927432", "R-RNO-5578768", "R-MMU-6798695", "R-DME-2022377", "R-RNO-2022377", "R-DME-5578768", "R-MMU-375276", "R-HSA-2022377", "R-RNO-6798695", "R-BTA-375276", "R-MMU-2022377"], "pathways": ["R-HSA-5578768:r:Physiological factors", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5578768:r:Physiological factors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-RNO-5578768:r:Physiological factors", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-5578768:r:Physiological factors", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Domain"}, "IPR018499": {"description": "Tetraspanin/Peripherin", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Tetraspanin/Peripherin", "pathway_ids": ["R-MMU-1300645", "R-HSA-6798695", "R-HSA-416993", "R-RNO-446107", "R-MMU-977606", "R-BTA-198933", "R-RNO-1300645", "R-RNO-198933", "R-HSA-1300645", "R-HSA-977225", "R-BTA-1300645", "R-CEL-6798695", "R-BTA-6798695", "R-RNO-114608", "R-RNO-977606", "R-HSA-114608", "R-HSA-9638630", "R-BTA-114608", "R-MMU-198933", "R-HSA-5336415", "R-HSA-2022090", "R-HSA-977606", "R-MMU-6798695", "R-HSA-198933", "R-HSA-446107", "R-BTA-977606", "R-HSA-202733", "R-RNO-6798695", "R-MMU-446107", "R-MMU-114608", "R-MMU-416993"], "pathways": ["R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-BTA-114608:r:Platelet degranulation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-BTA-977606:r:Regulation of Complement cascade", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-MMU-114608:r:Platelet degranulation", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors"], "type": "Family"}, "IPR018501": {"description": "DDT domain", "go_ids": [], "go_terms": [], "name": "DDT_dom", "pathway_ids": ["R-MMU-5693565", "R-DRE-5693565", "R-MMU-5250924", "R-HSA-5693565", "R-HSA-5250924", "R-DRE-5250924", "R-HSA-427413"], "pathways": ["R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-427413:r:NoRC negatively regulates rRNA expression"], "type": "Domain"}, "IPR018502": {"description": "Annexin repeat", "go_ids": ["GO:0005509", "GO:0005544"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0005544:calcium-dependent phospholipid binding:F"], "name": "Annexin_repeat", "pathway_ids": ["R-HSA-6798695", "R-MMU-416476", "R-MMU-444473", "R-RNO-444473", "R-CFA-9860927", "R-BTA-6798695", "R-HSA-416476", "R-DDI-114608", "R-DME-9860927", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-9860927", "R-HSA-114608", "R-HSA-444473", "R-RNO-75205", "R-RNO-416476", "R-HSA-75205", "R-DDI-6798695", "R-HSA-9925563", "R-HSA-445355", "R-DME-6798695", "R-DME-114608", "R-GGA-75205", "R-MMU-75205", "R-HSA-8950505", "R-GGA-114608", "R-HSA-6785807", "R-GGA-6798695", "R-MMU-9860927", "R-BTA-9860927", "R-HSA-418594", "R-BTA-75205", "R-CFA-75205", "R-MMU-6798695", "R-HSA-9860927", "R-CFA-6798695", "R-GGA-9860927", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-CFA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-416476:r:G alpha (q) signalling events", "R-DDI-114608:r:Platelet degranulation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-114608:r:Platelet degranulation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-445355:r:Smooth Muscle Contraction", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-114608:r:Platelet degranulation", "R-GGA-75205:r:Dissolution of Fibrin Clot", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-GGA-114608:r:Platelet degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-418594:r:G alpha (i) signalling events", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-CFA-75205:r:Dissolution of Fibrin Clot", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CFA-6798695:r:Neutrophil degranulation", "R-GGA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Repeat"}, "IPR018504": {"description": "RTX, pore-forming domain", "go_ids": ["GO:0015267", "GO:0005576"], "go_terms": ["GO:0015267:channel activity:F", "GO:0005576:extracellular region:C"], "name": "RTX_pore_form", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR018513": {"description": "Cellulose synthase BcsB, bacterial", "go_ids": ["GO:0006011", "GO:0016020"], "go_terms": ["GO:0006011:UDP-alpha-D-glucose metabolic process:P", "GO:0016020:membrane:C"], "name": "Cell_synthase_bac", "pathway_ids": ["R-HSA-9931953"], "pathways": ["R-HSA-9931953:r:Biofilm formation"], "type": "Family"}, "IPR018514": {"description": "Rabaptin coiled-coil domain", "go_ids": ["GO:0005096", "GO:0008083"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0008083:growth factor activity:F"], "name": "Rabaptin_CC", "pathway_ids": ["R-HSA-8854214"], "pathways": ["R-HSA-8854214:r:TBC/RABGAPs"], "type": "Domain"}, "IPR018515": {"description": "Tuberin-type domain", "go_ids": ["GO:0005096", "GO:0043547"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0043547:positive regulation of GTPase activity:P"], "name": "Tuberin-type_domain", "pathway_ids": ["R-RNO-8854214", "R-HSA-8854214", "R-MMU-380972", "R-HSA-5674400", "R-MMU-198323", "R-SPO-5628897", "R-MMU-1632852", "R-SPO-380972", "R-RNO-5628897", "R-SPO-165181", "R-RNO-165181", "R-HSA-5628897", "R-MMU-8854214", "R-SPO-198323", "R-HSA-198323", "R-RNO-1632852", "R-MMU-165181", "R-RNO-380972", "R-HSA-1632852", "R-MMU-5628897", "R-RNO-198323", "R-HSA-165181", "R-HSA-380972"], "pathways": ["R-RNO-8854214:r:TBC/RABGAPs", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-1632852:r:Macroautophagy", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-8854214:r:TBC/RABGAPs", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-1632852:r:Macroautophagy", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1632852:r:Macroautophagy", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK"], "type": "Domain"}, "IPR018530": {"description": "PA14_02130", "go_ids": [], "go_terms": [], "name": "PA14_02130", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018531": {"description": "Protein of unknown function DUF1993", "go_ids": [], "go_terms": [], "name": "DUF1993", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018533": {"description": "Forkhead box protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Forkhead_box_C", "pathway_ids": ["R-HSA-9925563", "R-HSA-9823730", "R-XTR-9018519", "R-HSA-9796292", "R-HSA-9937080", "R-HSA-210745", "R-HSA-9925561", "R-HSA-9764790", "R-RNO-9018519", "R-HSA-9018519", "R-MMU-9018519"], "pathways": ["R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-9823730:r:Formation of definitive endoderm", "R-XTR-9018519:r:Estrogen-dependent gene expression", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR018534": {"description": "Tetracycline regulation of excision, RteC", "go_ids": [], "go_terms": [], "name": "Tet_reg_excision_RteC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018535": {"description": "Domain of unknown function DUF1996", "go_ids": [], "go_terms": [], "name": "DUF1996", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018536": {"description": "Chromophore lyase CpcS/CpeS", "go_ids": ["GO:0017009"], "go_terms": ["GO:0017009:protein-phycocyanobilin linkage:P"], "name": "CpcS/CpeS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018537": {"description": "Peptidoglycan binding domain", "go_ids": [], "go_terms": [], "name": "Peptidoglycan-bd_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018538": {"description": "Helicase HerA, barrel domain", "go_ids": [], "go_terms": [], "name": "HerA_barrel_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018540": {"description": "Aspartyl-phosphate phosphatase Spo0E-like", "go_ids": ["GO:0043937"], "go_terms": ["GO:0043937:regulation of sporulation:P"], "name": "Spo0E-like", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR018541": {"description": "FtsK gamma domain", "go_ids": [], "go_terms": [], "name": "Ftsk_gamma", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018542": {"description": "Protein 9b, Betacoronavirus", "go_ids": [], "go_terms": [], "name": "Protein_9b_Betacoronavirus", "pathway_ids": ["R-HSA-9727281", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9679504", "R-HSA-9692916"], "pathways": ["R-HSA-9727281:r:Translation of Accessory Proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Family"}, "IPR018544": {"description": "KICSTOR subunit 2", "go_ids": [], "go_terms": [], "name": "KICS_2", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288", "R-DRE-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DRE-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR018545": {"description": "Btz domain", "go_ids": ["GO:0035145", "GO:0006397", "GO:0003729"], "go_terms": ["GO:0035145:exon-exon junction complex:C", "GO:0006397:mRNA processing:P", "GO:0003729:mRNA binding:F"], "name": "Btz_dom", "pathway_ids": ["R-RNO-975957", "R-BTA-975957", "R-MMU-72163", "R-HSA-9010553", "R-MMU-975957", "R-BTA-73856", "R-HSA-73856", "R-XTR-159236", "R-XTR-72163", "R-HSA-72187", "R-DRE-975957", "R-MMU-73856", "R-RNO-72163", "R-MMU-159236", "R-RNO-73856", "R-DRE-72163", "R-HSA-72163", "R-DRE-159236", "R-HSA-975957", "R-XTR-975957", "R-DRE-73856", "R-MMU-72187", "R-RNO-159236", "R-BTA-159236", "R-HSA-159236", "R-BTA-72163"], "pathways": ["R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72187:r:mRNA 3'-end processing", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR018546": {"description": "Domain of unknown function DUF2004", "go_ids": [], "go_terms": [], "name": "DUF2004", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018547": {"description": "AbiEi antitoxin C-terminal domain", "go_ids": [], "go_terms": [], "name": "AbiEi_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018548": {"description": "Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus", "go_ids": [], "go_terms": [], "name": "Spike_S1_RBD_bCoV", "pathway_ids": ["R-HSA-9679509", "R-HSA-9683686", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9694548", "R-HSA-9692916", "R-HSA-166662", "R-HSA-166663", "R-HSA-9694614", "R-HSA-9694322", "R-HSA-9694635"], "pathways": ["R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9694635:r:Translation of Structural Proteins"], "type": "Domain"}, "IPR018550": {"description": "Lipid A 3-O-deacylase-related", "go_ids": [], "go_terms": [], "name": "Lipid-A_deacylase-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018551": {"description": "Domain of unknown function DUF2007", "go_ids": [], "go_terms": [], "name": "DUF2007", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018552": {"description": "Centromere protein X", "go_ids": ["GO:0006281", "GO:0051382"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0051382:kinetochore assembly:P"], "name": "CENP-X", "pathway_ids": ["R-HSA-606279", "R-MMU-9833482", "R-HSA-9833482", "R-BTA-6783310", "R-MMU-606279", "R-BTA-9833482", "R-BTA-606279", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-BTA-9833482:r:PKR-mediated signaling", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR018553": {"description": "Non-canonical E2 ubiquitin-conjugating enzyme", "go_ids": [], "go_terms": [], "name": "E2_Ub-conjug_enz", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018554": {"description": "Frequency clock protein", "go_ids": ["GO:0006355", "GO:0007623", "GO:0005634", "GO:0005737"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0007623:circadian rhythm:P", "GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C"], "name": "FRQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018555": {"description": "C630.06c-like", "go_ids": [], "go_terms": [], "name": "C630.06c-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018556": {"description": "SPIN90/Ldb17, leucine-rich domain", "go_ids": [], "go_terms": [], "name": "SPIN90/Ldb17_LRD", "pathway_ids": ["R-HSA-5663213", "R-MMU-5663213", "R-HSA-2029482", "R-HSA-9664422", "R-MMU-2029482"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation"], "type": "Domain"}, "IPR018557": {"description": "THO complex subunit Thp2", "go_ids": ["GO:0006368", "GO:0000446", "GO:0006406"], "go_terms": ["GO:0006368:transcription elongation by RNA polymerase II:P", "GO:0000446:nucleoplasmic THO complex:C", "GO:0006406:mRNA export from nucleus:P"], "name": "THO_cplx_su_Thp2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018559": {"description": "Protein of unknown function DUF2015", "go_ids": [], "go_terms": [], "name": "DUF2015", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018560": {"description": "Domain of unknown function DUF2016", "go_ids": [], "go_terms": [], "name": "DUF2016", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018561": {"description": "Oxidative stress regulator AosR", "go_ids": [], "go_terms": [], "name": "AosR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018562": {"description": "ARS binding protein 2", "go_ids": [], "go_terms": [], "name": "ARS-binding_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018563": {"description": "Protein of unknown function DUF2018", "go_ids": [], "go_terms": [], "name": "DUF2018", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018564": {"description": "DNA replication checkpoint mediator, MRC1 domain", "go_ids": [], "go_terms": [], "name": "Repl_chkpnt_MRC1_dom", "pathway_ids": ["R-SCE-176187", "R-SPO-176187"], "pathways": ["R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SPO-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR018565": {"description": "Kinetochore subunit Nkp2/Cnl2", "go_ids": ["GO:0000776"], "go_terms": ["GO:0000776:kinetochore:C"], "name": "Nkp2/Cnl2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018566": {"description": "4-Methylmuconolactone methyl-isomerase", "go_ids": [], "go_terms": [], "name": "MeMu_Me-Isoase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018567": {"description": "Domain of unknown function DUF2020", "go_ids": [], "go_terms": [], "name": "DUF2020", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018568": {"description": "Domain of unknown function DUF2019", "go_ids": [], "go_terms": [], "name": "DUF2019", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018569": {"description": "Saf-pilin pilus formation protein", "go_ids": [], "go_terms": [], "name": "Saf-pilin_pilus_formation", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018570": {"description": "Phytotoxin, PcF", "go_ids": [], "go_terms": [], "name": "Phytotoxin_PcF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018571": {"description": "Membrane anchor Opy2, N-terminal", "go_ids": [], "go_terms": [], "name": "Membrane_anchor_Opy2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018572": {"description": "Protein of unknown function YopT", "go_ids": [], "go_terms": [], "name": "YopT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018573": {"description": "Restriction endonuclease, type II, AlwI", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_AlwI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018574": {"description": "Structure-specific endonuclease subunit Slx4, HTH domain", "go_ids": ["GO:0006281", "GO:0033557", "GO:0005634", "GO:0006260"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0033557:Slx1-Slx4 complex:C", "GO:0005634:nucleus:C", "GO:0006260:DNA replication:P"], "name": "Slx4_HTH", "pathway_ids": ["R-HSA-5693568", "R-HSA-6783310", "R-MMU-5693568", "R-MMU-6783310"], "pathways": ["R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR018575": {"description": "Restriction endonuclease, type II, Eco29kI, GIY-YIG domain", "go_ids": [], "go_terms": [], "name": "GYI-YIG_Eco29kI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018576": {"description": "Restriction endonuclease, type II, Pab1-like", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_Pab1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018577": {"description": "Restriction endonuclease, type II, Bpu10I", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_Bpu10I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018578": {"description": "Restriction endonuclease, type II, BstXI", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_BstXI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018579": {"description": "Restriction endonuclease, type II, LlaJI", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_LlaJI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018580": {"description": "Uncharacterised protein family YfhO", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YfhO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018581": {"description": "Type III secretion system, pilus formation, HrpA", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "T3SS_pilus_HrpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018582": {"description": "Envelope glycoprotein, lentivirus", "go_ids": [], "go_terms": [], "name": "Envelope_glycop_lentivirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018583": {"description": "Cotton leaf-curl disease, DNA-betaC1", "go_ids": [], "go_terms": [], "name": "CLCuD_DNA-betaC1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018584": {"description": "Glycosyltransferase family 87", "go_ids": ["GO:0016758"], "go_terms": ["GO:0016758:hexosyltransferase activity:F"], "name": "GT87", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR018585": {"description": "Major surface glycoprotein G, metapneumovirus", "go_ids": [], "go_terms": [], "name": "Metaviral_G_glycop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018586": {"description": "Brinker DNA-binding domain", "go_ids": [], "go_terms": [], "name": "Brinker_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018587": {"description": "White spot syndrome virus (WSSV), Orf116/126, N-terminal", "go_ids": [], "go_terms": [], "name": "WSSV_Orf116/126_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018588": {"description": "Dihaem cytochrome c", "go_ids": [], "go_terms": [], "name": "Dihaem_cytochrome-c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018589": {"description": "Pheromone response, PrgU-like domain", "go_ids": [], "go_terms": [], "name": "Pheromone_resp_PrgU-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018590": {"description": "Uncharacterised protein YvfG", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YvfG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018591": {"description": "YorP protein", "go_ids": [], "go_terms": [], "name": "YorP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018592": {"description": "Protein of unknown function DUF2024", "go_ids": [], "go_terms": [], "name": "DUF2024", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018593": {"description": "tRNA-splicing endonuclease subunit Sen15", "go_ids": [], "go_terms": [], "name": "tRNA-endonuc_su_Sen15", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR018594": {"description": "Domain of unknown function DUF2023", "go_ids": [], "go_terms": [], "name": "DUF2023", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018597": {"description": "Bacteriophage Tuc2009, YjcQ", "go_ids": [], "go_terms": [], "name": "Phage_Tuc2009_YjcQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018598": {"description": "Domain of unknown function DUF2027", "go_ids": [], "go_terms": [], "name": "DUF2027", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018599": {"description": "Protein of unknown function DUF2026", "go_ids": [], "go_terms": [], "name": "DUF2026", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018600": {"description": "Bacillus phage SPbeta, YonK", "go_ids": [], "go_terms": [], "name": "Phage_SP-beta_YonK", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018601": {"description": "Sulfolobus spindle-shape virus 1 F-112 protein-like", "go_ids": [], "go_terms": [], "name": "SSV1_F112-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018602": {"description": "Gp37/putative cytoplasmic protein STM4215", "go_ids": [], "go_terms": [], "name": "Gp37/STM4215", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018604": {"description": "Regulatory protein YycH-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "YycI-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018605": {"description": "Sororin protein", "go_ids": [], "go_terms": [], "name": "Sororin", "pathway_ids": ["R-HSA-2468052", "R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-2468052", "R-MMU-2467813"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids"], "type": "Family"}, "IPR018606": {"description": "Argonaute-binding protein 1", "go_ids": ["GO:0033167", "GO:0031047"], "go_terms": ["GO:0033167:ARC complex:C", "GO:0031047:regulatory ncRNA-mediated gene silencing:P"], "name": "Arb1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018607": {"description": "Chromosome transmission fidelity protein 8", "go_ids": ["GO:0031390", "GO:0007064"], "go_terms": ["GO:0031390:Ctf18 RFC-like complex:C", "GO:0007064:mitotic sister chromatid cohesion:P"], "name": "Ctf8", "pathway_ids": ["R-BTA-174411", "R-RNO-174411", "R-MMU-174411", "R-HSA-174411"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere"], "type": "Family"}, "IPR018608": {"description": "Global transcription regulator", "go_ids": [], "go_terms": [], "name": "Gti1/Pac2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018609": {"description": "Bud13", "go_ids": [], "go_terms": [], "name": "Bud13", "pathway_ids": ["R-HSA-72163", "R-RNO-72163", "R-MMU-72163", "R-CEL-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR018610": {"description": "UV-stimulated scaffold protein A", "go_ids": ["GO:0009411"], "go_terms": ["GO:0009411:response to UV:P"], "name": "UVSSA", "pathway_ids": ["R-RNO-6781823", "R-DRE-6782210", "R-HSA-6781827", "R-MMU-6782135", "R-RNO-6782135", "R-HSA-6782135", "R-CEL-6782210", "R-HSA-6781823", "R-CEL-6781823", "R-MMU-6781823", "R-DRE-6782135", "R-XTR-6782210", "R-CEL-6782135", "R-XTR-6782135", "R-HSA-6782210", "R-MMU-6782210", "R-XTR-6781823", "R-DRE-6781823", "R-RNO-6782210"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6782135:r:Dual incision in TC-NER", "R-XTR-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-XTR-6782135:r:Dual incision in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER"], "type": "Family"}, "IPR018611": {"description": "E3 UFM1-protein ligase 1", "go_ids": ["GO:0071569", "GO:0061666"], "go_terms": ["GO:0071569:protein ufmylation:P", "GO:0061666:UFM1 ligase activity:F"], "name": "Ufl1", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-BTA-983168", "R-DDI-983168", "R-DME-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-MMU-983168", "R-DRE-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR018612": {"description": "Nuclear speckle splicing regulatory protein 1, N-terminal", "go_ids": ["GO:0000381"], "go_terms": ["GO:0000381:regulation of alternative mRNA splicing, via spliceosome:P"], "name": "NSRP1_N", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-CEL-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR018613": {"description": "Ccdc97-like", "go_ids": [], "go_terms": [], "name": "Ccdc97-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018614": {"description": "Keratinocyte-associated protein 2", "go_ids": [], "go_terms": [], "name": "KRTCAP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018615": {"description": "Large ribosomal subunit protein mL55", "go_ids": ["GO:0005762", "GO:0003735"], "go_terms": ["GO:0005762:mitochondrial large ribosomal subunit:C", "GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_mL55", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-DME-9937383"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR018616": {"description": "Protein GUCD1", "go_ids": [], "go_terms": [], "name": "GUCD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018617": {"description": "Ima1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ima1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018618": {"description": "GID complex substrate-recognition subunit 4/10-like", "go_ids": [], "go_terms": [], "name": "GID4/10-like", "pathway_ids": ["R-HSA-9861718", "R-MMU-9861718"], "pathways": ["R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism"], "type": "Family"}, "IPR018619": {"description": "Hyccin", "go_ids": [], "go_terms": [], "name": "Hyccin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018620": {"description": "Ubiquitin 3 binding protein But2, C-terminal", "go_ids": [], "go_terms": [], "name": "Ubiquitin3-bd_protein_But2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018621": {"description": "Autophagy-related protein 31", "go_ids": ["GO:0006914", "GO:0000407"], "go_terms": ["GO:0006914:autophagy:P", "GO:0000407:phagophore assembly site:C"], "name": "Atg31", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018622": {"description": "DNA damage checkpoint protein, Lcd1", "go_ids": ["GO:0000077"], "go_terms": ["GO:0000077:DNA damage checkpoint signaling:P"], "name": "DNA_damage_chkpnt_Lcd1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018624": {"description": "Translocation protein Sec66", "go_ids": ["GO:0031204", "GO:0031207"], "go_terms": ["GO:0031204:post-translational protein targeting to membrane, translocation:P", "GO:0031207:Sec62/Sec63 complex:C"], "name": "Sec66", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018625": {"description": "Protein Pet100", "go_ids": ["GO:0005739", "GO:0033617"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0033617:mitochondrial respiratory chain complex IV assembly:P"], "name": "Pet100", "pathway_ids": ["R-HSA-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR018626": {"description": "Protein LCHN/Anr2", "go_ids": [], "go_terms": [], "name": "LCHN/Anr2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018627": {"description": "Elongator complex protein 6", "go_ids": ["GO:0002098", "GO:0033588"], "go_terms": ["GO:0002098:tRNA wobble uridine modification:P", "GO:0033588:elongator holoenzyme complex:C"], "name": "ELP6", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR018628": {"description": "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "Coa3_CC", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848", "R-BTA-9864848", "R-DME-9864848", "R-DRE-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-DME-9864848:r:Complex IV assembly", "R-DRE-9864848:r:Complex IV assembly"], "type": "Domain"}, "IPR018629": {"description": "XK-related protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "XK-rel", "pathway_ids": ["R-MMU-375276", "R-RNO-375276", "R-HSA-375276"], "pathways": ["R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors"], "type": "Family"}, "IPR018630": {"description": "RZZ complex, subunit Zwilch", "go_ids": ["GO:1990423", "GO:0007093"], "go_terms": ["GO:1990423:RZZ complex:C", "GO:0007093:mitotic cell cycle checkpoint signaling:P"], "name": "Zwilch", "pathway_ids": ["R-MMU-2500257", "R-XTR-9648025", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-DRE-2500257", "R-MMU-2467813", "R-XTR-2467813", "R-MMU-9648025", "R-HSA-141444", "R-XTR-5663220", "R-BTA-5663220", "R-DRE-2467813", "R-XTR-68877", "R-DRE-141444", "R-MMU-68877", "R-HSA-9648025", "R-XTR-141444", "R-BTA-2467813", "R-HSA-68877", "R-BTA-2500257", "R-HSA-5663220", "R-DRE-5663220", "R-BTA-9648025", "R-BTA-141444", "R-XTR-2500257", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-XTR-68877:r:Mitotic Prometaphase", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR018631": {"description": "AAA-ATPase-like domain", "go_ids": [], "go_terms": [], "name": "AAA-ATPase-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018632": {"description": "C-terminal AAA-associated domain", "go_ids": [], "go_terms": [], "name": "AAA-associated_dom_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018633": {"description": "Domain of unknown function DUF2357", "go_ids": [], "go_terms": [], "name": "DUF2357", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018634": {"description": "ChrB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ChrB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018635": {"description": "Uncharacterised protein family UPF0319", "go_ids": [], "go_terms": [], "name": "UPF0319", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018636": {"description": "Protein of unknown function DUF2058", "go_ids": [], "go_terms": [], "name": "DUF2058", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018637": {"description": "Domain of unknown function DUF2059", "go_ids": [], "go_terms": [], "name": "DUF2059", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018638": {"description": "Domain of unknown function DUF2061, membrane", "go_ids": [], "go_terms": [], "name": "DUF2061_membrane", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018639": {"description": "Domain of unknown function DUF2062", "go_ids": [], "go_terms": [], "name": "DUF2062", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018640": {"description": "HvfC, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HvfC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018641": {"description": "Transferase 1, rSAM/selenodomain-associated", "go_ids": [], "go_terms": [], "name": "Trfase_1_rSAM/seldom-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018642": {"description": "Domain of unknown function DUF2066", "go_ids": [], "go_terms": [], "name": "DUF2066", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018643": {"description": "Protein of unknown function DUF2069, membrane", "go_ids": [], "go_terms": [], "name": "DUF2069_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018644": {"description": "Protein of unknown function DUF2071", "go_ids": [], "go_terms": [], "name": "DUF2071", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018645": {"description": "Origin-associated protein OapC-like", "go_ids": [], "go_terms": [], "name": "OapC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018646": {"description": "Membrane protein of 12 TMs", "go_ids": [], "go_terms": [], "name": "12TM_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018647": {"description": "Schlafen group 3-like, DNA/RNA helicase domain", "go_ids": [], "go_terms": [], "name": "SLFN_3-like_DNA/RNA_helicase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018648": {"description": "Protein of unknown function DUF2076", "go_ids": [], "go_terms": [], "name": "DUF2076", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018649": {"description": "SHOCT domain", "go_ids": [], "go_terms": [], "name": "SHOCT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018650": {"description": "Sulfolobus virus STSV1, Orf64", "go_ids": [], "go_terms": [], "name": "STSV1_Orf64", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018652": {"description": "Protein of unknown function DUF2082, nucleic-acid-binding, Zn-ribbon", "go_ids": [], "go_terms": [], "name": "DUF2082_NA-bd_Znr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018653": {"description": "Short-chain fatty acyl coenzyme A regulators, C-terminal", "go_ids": [], "go_terms": [], "name": "ScfR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018654": {"description": "Putative toxin of bacterial toxin-antitoxin pair", "go_ids": [], "go_terms": [], "name": "YjhX_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018655": {"description": "Protein of unknown function DUF2086", "go_ids": [], "go_terms": [], "name": "DUF2086", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018656": {"description": "Domain of unknown function DUF2087", "go_ids": [], "go_terms": [], "name": "DUF2087", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018657": {"description": "LarA-like, N-terminal", "go_ids": ["GO:0050043"], "go_terms": ["GO:0050043:lactate racemase activity:F"], "name": "LarA-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018658": {"description": "Domain of unknown function DUF2089", "go_ids": [], "go_terms": [], "name": "DUF2089", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018659": {"description": "Domain of unknown function DUF2090", "go_ids": [], "go_terms": [], "name": "DUF2090", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018660": {"description": "C-type lysozyme inhibitor", "go_ids": [], "go_terms": [], "name": "MliC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018661": {"description": "Protein of unknown function DUF2093", "go_ids": [], "go_terms": [], "name": "DUF2093", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018662": {"description": "Protein of unknown function DUF2095", "go_ids": [], "go_terms": [], "name": "DUF2095", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018663": {"description": "Protein of unknown function DUF2101, membrane", "go_ids": [], "go_terms": [], "name": "DUF2101_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018664": {"description": "Protein of unknown function DUF2103, metal-binding", "go_ids": [], "go_terms": [], "name": "DUF2103_metal-binding", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018665": {"description": "Putative type II restriction enzyme MjaORF1200P-like", "go_ids": [], "go_terms": [], "name": "MJ1199-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018666": {"description": "Protein of unknown function DUF2125", "go_ids": [], "go_terms": [], "name": "DUF2125", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018667": {"description": "Domain of unknown function DUF2126", "go_ids": [], "go_terms": [], "name": "DUF2126", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018668": {"description": "DNA-binding protein VF530-like", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "DNA-binding_VF530-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018669": {"description": "Toxin-antitoxin system, mRNA interferase HigB", "go_ids": ["GO:0090304", "GO:0110001", "GO:0004519", "GO:0003723"], "go_terms": ["GO:0090304:nucleic acid metabolic process:P", "GO:0110001:toxin-antitoxin complex:C", "GO:0004519:endonuclease activity:F", "GO:0003723:RNA binding:F"], "name": "Toxin_HigB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018671": {"description": "Protein of unknown function DUF2138", "go_ids": [], "go_terms": [], "name": "DUF2138", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018672": {"description": "Protein of unknown function DUF2140", "go_ids": [], "go_terms": [], "name": "DUF2140", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018673": {"description": "Protein of unknown function DUF2141", "go_ids": [], "go_terms": [], "name": "DUF2141", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018674": {"description": "Protein of unknown function DUF2142, membrane", "go_ids": [], "go_terms": [], "name": "DUF2142_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018676": {"description": "Protein of unknown function DUF2149", "go_ids": [], "go_terms": [], "name": "DUF2149", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018677": {"description": "Domain of unknown function DUF2157", "go_ids": [], "go_terms": [], "name": "DUF2157", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018678": {"description": "Protein of unknown function DUF2160, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF2160_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018679": {"description": "Putative PD-(D/E)XK phosphodiesterase (DUF2161)", "go_ids": [], "go_terms": [], "name": "DUF2161", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018680": {"description": "Protein of unknown function DUF2164", "go_ids": [], "go_terms": [], "name": "DUF2164", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018681": {"description": "Protein of unknown function DUF2165, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF2165_transmembrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018682": {"description": "Protein of unknown function DUF2167, membrane", "go_ids": [], "go_terms": [], "name": "DUF2167_membr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018683": {"description": "Domain of unknown function DUF2169", "go_ids": [], "go_terms": [], "name": "DUF2169", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018684": {"description": "Protein of unknown function DUF2171", "go_ids": [], "go_terms": [], "name": "DUF2171", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018685": {"description": "Protein of unknown function DUF2173", "go_ids": [], "go_terms": [], "name": "DUF2173", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018686": {"description": "Protein of unknown function DUF2175", "go_ids": [], "go_terms": [], "name": "DUF2175", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018687": {"description": "Protein of unknown function DUF2177, membrane", "go_ids": [], "go_terms": [], "name": "DUF2177_membr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018688": {"description": "Copper chaperone PpoB2-like", "go_ids": [], "go_terms": [], "name": "PpoB2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018689": {"description": "Immunity protein Imm33 domain", "go_ids": [], "go_terms": [], "name": "Imm33_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018690": {"description": "Protein of unknown function DUF2187", "go_ids": [], "go_terms": [], "name": "DUF2187", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018691": {"description": "Protein of unknown function DUF2188", "go_ids": [], "go_terms": [], "name": "DUF2188", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018692": {"description": "Predicted integral membrane protein DUF2189", "go_ids": [], "go_terms": [], "name": "DUF2189", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018693": {"description": "Protein of unknown function DUF2192", "go_ids": [], "go_terms": [], "name": "DUF2192", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018694": {"description": "Protein of unknown function DUF2193", "go_ids": [], "go_terms": [], "name": "DUF2193", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018695": {"description": "Protein of unknown function DUF2194", "go_ids": [], "go_terms": [], "name": "DUF2194", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018696": {"description": "Protein of unknown function DUF2195", "go_ids": [], "go_terms": [], "name": "DUF2195", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018697": {"description": "Protein of unknown function DUF2199", "go_ids": [], "go_terms": [], "name": "DUF2199", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018698": {"description": "VWA-like domain", "go_ids": [], "go_terms": [], "name": "VWA-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018699": {"description": "Protein of unknown function DUF2203", "go_ids": [], "go_terms": [], "name": "DUF2203", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018700": {"description": "Protein of unknown function DUF2204", "go_ids": [], "go_terms": [], "name": "DUF2204", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018701": {"description": "Protein of unknown function DUF2206, membrane", "go_ids": [], "go_terms": [], "name": "DUF2206_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018702": {"description": "Domain of unknown function DUF2207", "go_ids": [], "go_terms": [], "name": "DUF2207", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018704": {"description": "Ancillary SecYEG translocon subunit/Cell division coordinator CpoB, TPR domain", "go_ids": [], "go_terms": [], "name": "SecYEG/CpoB_TPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018705": {"description": "Domain of unknown function DUF2134, membrane", "go_ids": [], "go_terms": [], "name": "DUF2134_membrane", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018706": {"description": "Protein of unknown function DUF2214, membrane", "go_ids": [], "go_terms": [], "name": "DUF2214_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018707": {"description": "Lipid A deacylase LpxR", "go_ids": [], "go_terms": [], "name": "LpxR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018708": {"description": "Protein of unknown function DUF2225", "go_ids": [], "go_terms": [], "name": "DUF2225", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018709": {"description": "CoA enzyme activase, domain of unknown function DUF2229", "go_ids": [], "go_terms": [], "name": "CoA_activase_DUF2229", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018710": {"description": "Protein of unknown function DUF2232", "go_ids": [], "go_terms": [], "name": "DUF2232", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018711": {"description": "Phosphodiester glycosidase", "go_ids": [], "go_terms": [], "name": "NAGPA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018712": {"description": "T6SS, Phospholipase effector Tle1-like, catalytic domain", "go_ids": [], "go_terms": [], "name": "Tle1-like_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018713": {"description": "ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase, catalytic domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "MPAB/Lcp_cat_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018714": {"description": "Protein of unknown function DUF2237", "go_ids": [], "go_terms": [], "name": "DUF2237", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018715": {"description": "Protein of unknown function DUF2239", "go_ids": [], "go_terms": [], "name": "DUF2239", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018716": {"description": "Protein of unknown function DUF2240", "go_ids": [], "go_terms": [], "name": "DUF2240", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018717": {"description": "Domain of unknown function DUF2241", "go_ids": [], "go_terms": [], "name": "DUF2241", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018718": {"description": "Protein of unknown function DUF2242", "go_ids": [], "go_terms": [], "name": "DUF2242", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018719": {"description": "Protein of unknown function DUF2243, membrane", "go_ids": [], "go_terms": [], "name": "DUF2243_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018720": {"description": "Domain of unknown function DUF2249", "go_ids": [], "go_terms": [], "name": "DUF2249", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018721": {"description": "Protein of unknown function DUF2252", "go_ids": [], "go_terms": [], "name": "DUF2252", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018723": {"description": "Protein of unknown function DUF2254, membrane", "go_ids": [], "go_terms": [], "name": "DUF2254_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018724": {"description": "2OG-Fe dioxygenase", "go_ids": ["GO:0051213"], "go_terms": ["GO:0051213:dioxygenase activity:F"], "name": "2OG-Fe_dioxygenase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018725": {"description": "Protein of unknown function DUF2259, secreted", "go_ids": [], "go_terms": [], "name": "DUF2259_secreted", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018727": {"description": "Protein of unknown function DUF2267", "go_ids": [], "go_terms": [], "name": "DUF2267", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018728": {"description": "Domain of unknown function DUF2268", "go_ids": [], "go_terms": [], "name": "DUF2268", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018729": {"description": "Protein of unknown function DUF2269, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF2269_transmembrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018730": {"description": "Protein of unknown function DUF2273", "go_ids": [], "go_terms": [], "name": "DUF2273", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018731": {"description": "Autophagy-related protein 13, N-terminal", "go_ids": ["GO:1990316", "GO:0006914"], "go_terms": ["GO:1990316:Atg1/ULK1 kinase complex:C", "GO:0006914:autophagy:P"], "name": "Atg13_N", "pathway_ids": ["R-DME-1632852", "R-SCE-1632852", "R-HSA-1632852", "R-MMU-1632852", "R-SPO-1632852", "R-DRE-1632852"], "pathways": ["R-DME-1632852:r:Macroautophagy", "R-SCE-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-DRE-1632852:r:Macroautophagy"], "type": "Domain"}, "IPR018732": {"description": "Dpy-19/Dpy-19-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Dpy-19/Dpy-19-like", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR018733": {"description": "Protein of unknown function DUF2274", "go_ids": [], "go_terms": [], "name": "DUF2274", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018734": {"description": "Domain of unknown function DUF2275", "go_ids": [], "go_terms": [], "name": "DUF2275", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018735": {"description": "Protein of unknown function DUF2277", "go_ids": [], "go_terms": [], "name": "DUF2277", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018736": {"description": "Protein of unknown function DUF2279, periplasmic lipoprotein", "go_ids": [], "go_terms": [], "name": "DUF2279_periplasmic_lipo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018737": {"description": "Protein LIN52", "go_ids": ["GO:0070176", "GO:0006355"], "go_terms": ["GO:0070176:DRM complex:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "DREAM_LIN52", "pathway_ids": ["R-MMU-1538133", "R-HSA-69656", "R-CEL-1538133", "R-HSA-1362277", "R-HSA-69205", "R-HSA-1362300", "R-HSA-156711", "R-DRE-1538133", "R-HSA-1538133", "R-HSA-69202"], "pathways": ["R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-156711:r:Polo-like kinase mediated events", "R-DRE-1538133:r:G0 and Early G1", "R-HSA-1538133:r:G0 and Early G1", "R-HSA-69202:r:Cyclin E associated events during G1/S transition"], "type": "Family"}, "IPR018738": {"description": "Protein of unknown function DUF2280", "go_ids": [], "go_terms": [], "name": "DUF2280", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018739": {"description": "Domain of unknown function DUF2281", "go_ids": [], "go_terms": [], "name": "DUF2281", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018740": {"description": "BufA1 family periplasmic bufferin-type metallophore", "go_ids": ["GO:0005507"], "go_terms": ["GO:0005507:copper ion binding:F"], "name": "BufA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018741": {"description": "Protein of unknown function DUF2288", "go_ids": [], "go_terms": [], "name": "DUF2288", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018742": {"description": "Protein of unknown function DUF2290", "go_ids": [], "go_terms": [], "name": "DUF2290", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018743": {"description": "Protein of unknown function DUF2292", "go_ids": [], "go_terms": [], "name": "DUF2292", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018744": {"description": "Domain of unknown function DUF2293", "go_ids": [], "go_terms": [], "name": "DUF2293", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018745": {"description": "Na+-translocating membrane potential-generating system MpsC", "go_ids": [], "go_terms": [], "name": "MpsC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018746": {"description": "Protein of unknown function DUF2298", "go_ids": [], "go_terms": [], "name": "DUF2298", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018747": {"description": "Protein of unknown function DUF2299", "go_ids": [], "go_terms": [], "name": "DUF2299", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018748": {"description": "Domain of unknown function DUF2300, secreted", "go_ids": [], "go_terms": [], "name": "DUF2300_secreted", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018750": {"description": "Protein of unknown function DUF2306, membrane", "go_ids": [], "go_terms": [], "name": "DUF2306_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018752": {"description": "Probable inorganic carbon transporter subunit DabA", "go_ids": [], "go_terms": [], "name": "DabA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018754": {"description": "T6SS, Transcription factor RovC-like, DNA binding domain", "go_ids": [], "go_terms": [], "name": "RovC-like_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018755": {"description": "Bacteriophage Mu-like, Gp48", "go_ids": [], "go_terms": [], "name": "Phage_Mu_Gp48", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018756": {"description": "Domain of unknown function DUF2314", "go_ids": [], "go_terms": [], "name": "DUF2314", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018757": {"description": "Protein of unknown function DUF2316", "go_ids": [], "go_terms": [], "name": "DUF2316", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018758": {"description": "Membrane iron-sulfur containing protein FtrD-like", "go_ids": [], "go_terms": [], "name": "FtrD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018759": {"description": "Putative beta-barrel porin 2", "go_ids": [], "go_terms": [], "name": "BBP2_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018760": {"description": "Domain of unknown function DUF2326", "go_ids": [], "go_terms": [], "name": "DUF2326", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018762": {"description": "Histidine phosphotransferase ChpT, C-terminal", "go_ids": [], "go_terms": [], "name": "ChpT_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018763": {"description": "Domain of unknown function DUF2334", "go_ids": [], "go_terms": [], "name": "DUF2334", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018764": {"description": "Anti-sigma K factor RskA, C-terminal", "go_ids": ["GO:0005886", "GO:0016020"], "go_terms": ["GO:0005886:plasma membrane:C", 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[], "name": "VgrG2_DUF2345", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018770": {"description": "5-bromo-4-chloroindolyl phosphate hydrolysis protein", "go_ids": [], "go_terms": [], "name": "ChloroindolylP_hydrolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018771": {"description": "PocR domain", "go_ids": [], "go_terms": [], "name": "PocR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018772": {"description": "Transcription activator HlyU", "go_ids": [], "go_terms": [], "name": "Transcription_activator_HlyU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018773": {"description": "Methyltransferase regulatory domain, predicted", "go_ids": [], "go_terms": [], "name": "MeTrfase_reg_dom_prd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018774": {"description": "Bacteriophage Mu, GpT", "go_ids": [], "go_terms": [], "name": "Phage_Mu_GpT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018775": {"description": "RNA repair pathway DNA polymerase beta", "go_ids": [], "go_terms": [], "name": "RlaP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018776": {"description": "Membrane protein, 6-pyruvoyl-tetrahydropterin synthase-related domain", "go_ids": [], "go_terms": [], "name": "Membrane_prot_PTPS-rel_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018777": {"description": "Replication initiator protein A", "go_ids": [], "go_terms": [], "name": "Replication_initiator_prot_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018778": {"description": "Type VII secretion system EssB", "go_ids": [], "go_terms": [], "name": "T7SS_EssB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018779": {"description": "Single-stranded-DNA-specific exonuclease RecJ, C-terminal", "go_ids": [], "go_terms": [], "name": "RecJ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018780": {"description": "BLOC-1-related complex subunit 5", 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"R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-8949664:r:Processing of SMDT1", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DME-8949664:r:Processing of SMDT1", "R-MMU-8949215:r:Mitochondrial calcium ion transport", "R-CEL-8949664:r:Processing of SMDT1", "R-HSA-8949664:r:Processing of SMDT1", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-8949664:r:Processing of SMDT1", "R-DME-8949215:r:Mitochondrial calcium ion transport", "R-CEL-8949215:r:Mitochondrial calcium ion transport", "R-BTA-8949215:r:Mitochondrial calcium ion transport"], "type": "Family"}, "IPR018783": {"description": "Transcription factor, enhancer of yellow 2", "go_ids": ["GO:0000124", "GO:0006406", "GO:0045893", "GO:0003713"], "go_terms": ["GO:0000124:SAGA complex:C", "GO:0006406:mRNA export from nucleus:P", "GO:0045893:positive regulation of DNA-templated transcription:P", "GO:0003713:transcription coactivator activity:F"], "name": "TF_ENY2", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR018784": {"description": "LLP homolog-like", "go_ids": [], "go_terms": [], "name": "LLPH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018785": {"description": "Cysteine-rich DPF motif domain", "go_ids": [], "go_terms": [], "name": "CDPF1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018786": {"description": "Mitochondrial K+-H+ exchange-related", "go_ids": [], "go_terms": [], "name": "Mit_KHE1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018787": {"description": "Protein of unknown function DUF2371, TMEM200", "go_ids": [], "go_terms": [], "name": "DUF2371_TMEM200", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018788": {"description": "Proteasome assembly chaperone 3", "go_ids": ["GO:0043248"], "go_terms": ["GO:0043248:proteasome 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["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR018799": {"description": "TRAF3-interacting protein 1", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "TRAF3IP1", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR018800": {"description": "Proline-rich protein PRCC", "go_ids": [], "go_terms": [], "name": "PRCC", "pathway_ids": ["R-HSA-9918481", "R-HSA-72163", "R-DDI-72163"], "pathways": ["R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR018801": {"description": "E3 ubiquitin-protein ligase TM129", "go_ids": ["GO:0061630", "GO:0016020", "GO:0016567"], "go_terms": ["GO:0061630:ubiquitin protein 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UPF0662", "go_ids": [], "go_terms": [], "name": "UPF0662", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018811": {"description": "MIOREX complex component 11", "go_ids": [], "go_terms": [], "name": "MRX11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018812": {"description": "Swiss Army Knife RNA repair protein, HAD domain", "go_ids": [], "go_terms": [], "name": "SAK_HAD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018814": {"description": "Maintenance of telomere capping protein 1", "go_ids": [], "go_terms": [], "name": "MTC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018815": {"description": "Increased loss of mitochondrial DNA protein 1", "go_ids": [], "go_terms": [], "name": "Incr_loss_mito_DNA_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018816": {"description": "Splicing factor cactin, central domain", "go_ids": [], "go_terms": [], "name": "Cactin_central", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", 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"pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018821": {"description": "Domain of unknown function DUF294, putative nucleotidyltransferase substrate-binding", "go_ids": [], "go_terms": [], "name": "DUF294_put_nucleoTrafse_sb-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018822": {"description": "Uncharacterised protein family UPF0646", "go_ids": [], "go_terms": [], "name": "UPF0646", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018823": {"description": "Putative ER transporter, 6TM, N-terminal", "go_ids": [], "go_terms": [], "name": "ArAE_2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018824": {"description": "Conidiation-specific protein 6", "go_ids": [], "go_terms": [], "name": "Conidiation-specific_6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018825": {"description": "Domain of unknown function DUF2427", "go_ids": [], "go_terms": [], "name": "DUF2427", "pathway_ids": [], "pathways": [], "type": "Domain"}, 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"RNA-binding domain, putative", "go_ids": [], "go_terms": [], "name": "RNA-binding_domain_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018836": {"description": "Necrogenic protein Nec1", "go_ids": [], "go_terms": [], "name": "Necrogenic_Nec1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018837": {"description": "Transcription factor CRF1/IFH1", "go_ids": ["GO:0060962", "GO:0003712"], "go_terms": ["GO:0060962:regulation of ribosomal protein gene transcription by RNA polymerase II:P", "GO:0003712:transcription coregulator activity:F"], "name": "TF_CRF1/IFH1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018838": {"description": "5'-3' DNA helicase ZGRF1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ZGRF1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018839": {"description": "Cryptic loci regulator 2, C-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt-silencing_Clr2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018840": {"description": "Protein of unknown function DUF2441", "go_ids": [], "go_terms": [], "name": "DUF2441", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018841": {"description": "Protein of unknown function DUF2442", "go_ids": [], "go_terms": [], "name": "DUF2442", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018842": {"description": "YkuI, C-terminal", "go_ids": [], "go_terms": [], "name": "YkuI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018843": {"description": "Utp8, beta-propeller", "go_ids": [], "go_terms": [], "name": "Utp8_b-prop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018844": {"description": "Nucleolar protein Dnt1-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Dnt1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018845": {"description": "Initiator binding domain", "go_ids": [], "go_terms": [], "name": "Initiator-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018846": {"description": "RSE1/DDB1/CPSF1, first beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_RSE1/DDB1/CPSF1_1st", "pathway_ids": ["R-RNO-6781823", "R-CEL-159231", "R-DME-110314", "R-MMU-9770562", "R-HSA-8951664", "R-DME-6781823", "R-DME-8951664", "R-HSA-73856", "R-DME-72163", "R-DDI-6782210", "R-HSA-72187", "R-RNO-110314", "R-DME-5696394", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-110314", "R-MMU-8951664", "R-SPO-5696395", "R-CEL-110314", "R-MMU-5696395", "R-CEL-9770562", "R-MMU-5696394", "R-DME-73856", "R-CEL-5696394", "R-DME-6782135", "R-RNO-6782210", "R-BTA-72163", "R-DRE-77595", "R-MMU-72163", "R-SCE-77595", "R-HSA-6784531", "R-RNO-5696395", "R-DDI-6781823", "R-MMU-73856", "R-CEL-6782210", "R-SPO-77595", "R-RNO-5696394", "R-HSA-159231", "R-CEL-6781823", "R-SPO-9770562", "R-HSA-72163", "R-DME-72165", "R-DDI-5696394", "R-SPO-110314", "R-HSA-5696395", "R-CEL-6782135", "R-HSA-5696394", "R-CEL-5696395", "R-RNO-8951664", "R-BTA-9770562", "R-SPO-8951664", "R-MMU-6782210", "R-HSA-110314", "R-DDI-6782135", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-DME-77595", "R-SPO-159231", "R-MMU-77595", "R-DME-159231", "R-DDI-9770562", "R-CEL-73856", "R-CEL-77595", "R-HSA-77595", "R-DME-9770562", "R-MMU-6781823", "R-DRE-73856", "R-GGA-353303", "R-DRE-9770562", "R-HSA-6782210", "R-HSA-72165", "R-HSA-9918481", "R-MMU-159231", "R-MMU-5696400", "R-BTA-72165", "R-HSA-9770562", "R-RNO-6782135", "R-HSA-6782135", "R-DME-5696395", "R-MMU-72187", "R-SPO-5696400", "R-MMU-72165", "R-DME-5696400", "R-SPO-6782210", "R-RNO-5696400", "R-HSA-5696400", "R-DME-6782210", "R-SPO-6782135", "R-DRE-72165", "R-CEL-8951664"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8951664:r:Neddylation", 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- Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-8951664:r:Neddylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-SPO-8951664:r:Neddylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-GGA-353303:r:Nucleotide Excision Repair", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-72187:r:mRNA 3'-end processing", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR018847": {"description": "Monopolin complex, subunit Mam1", "go_ids": [], "go_terms": [], "name": "Monopolin_cplx_su_Mam1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018848": {"description": "WIYLD domain", "go_ids": [], "go_terms": [], "name": "WIYLD_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018849": {"description": "Nucleolar 27S pre-rRNA processing, Urb2/Npa2, C-terminal", "go_ids": [], "go_terms": [], "name": "Urb2/Npa2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018850": {"description": "Mitochondrial escape protein 2, C-terminal", "go_ids": [], "go_terms": [], "name": "Mt_escape_2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018851": {"description": "Borealin, N-terminal", "go_ids": [], "go_terms": [], "name": "Borealin_N", "pathway_ids": ["R-RNO-4615885", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-XTR-4615885", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-RNO-2500257", "R-DRE-2500257", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-HSA-9648025", "R-DRE-2467813", "R-DRE-141444", "R-RNO-5663220", "R-XTR-68877", "R-MMU-68877", "R-MMU-4615885", "R-XTR-141444", "R-HSA-68877", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-DRE-5663220", "R-HSA-4615885", "R-MMU-9648025", "R-XTR-2500257", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-68877:r:Mitotic Prometaphase", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Domain"}, "IPR018852": {"description": "Protein of unknown function DUF2456", "go_ids": [], "go_terms": [], "name": "DUF2456", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018853": {"description": "Protein of unknown function DUF2457", "go_ids": [], "go_terms": [], "name": "DUF2457", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018854": {"description": "Proteasome chaperone 3/4", "go_ids": [], "go_terms": [], "name": "Psome_chaperone_3/4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018855": {"description": "Proteasome chaperone 1, fungi", "go_ids": ["GO:0043248"], "go_terms": ["GO:0043248:proteasome assembly:P"], "name": "Psome_chaperone_1_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018856": {"description": "CST complex subunit Stn1, N-terminal", "go_ids": [], "go_terms": [], "name": "Stn1_N", "pathway_ids": ["R-RNO-174411", "R-BTA-174411", "R-MMU-174430", "R-MMU-174411", "R-RNO-174430", "R-BTA-174430", "R-DRE-174430"], "pathways": ["R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-DRE-174430:r:Telomere C-strand synthesis initiation"], "type": "Domain"}, "IPR018857": {"description": "TORC1 complex, subunit TCO89", "go_ids": ["GO:0031931", "GO:0031929"], "go_terms": ["GO:0031931:TORC1 complex:C", "GO:0031929:TOR signaling:P"], "name": "TORC1_cplx_su_TCO89", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018858": {"description": "Protein of unknown function DUF2458", "go_ids": [], "go_terms": [], "name": "DUF2458", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018859": {"description": "BAR domain-containing family", "go_ids": [], "go_terms": [], "name": "BAR_dom-cont", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018860": {"description": "Anaphase-promoting complex, subunit CDC26", "go_ids": ["GO:0005680", "GO:0031145"], "go_terms": ["GO:0005680:anaphase-promoting complex:C", "GO:0031145:anaphase-promoting complex-dependent catabolic process:P"], "name": "APC_suCDC26", "pathway_ids": ["R-BTA-983168", "R-HSA-174178", "R-RNO-2559582", "R-DRE-141430", "R-DRE-174048", "R-BTA-179409", "R-MMU-174154", "R-MMU-2467813", "R-BTA-141430", "R-MMU-69017", "R-DRE-2467813", "R-BTA-176409", "R-DDI-179409", "R-HSA-141430", "R-RNO-174154", "R-DDI-2559582", "R-DDI-176407", "R-DRE-69017", "R-HSA-176408", "R-MMU-174084", "R-BTA-68867", "R-DRE-174184", "R-HSA-68867", "R-RNO-141430", "R-HSA-176409", "R-MMU-176409", "R-DDI-174084", "R-MMU-68867", "R-RNO-176412", "R-BTA-174084", "R-HSA-9687136", "R-BTA-2559582", "R-RNO-174048", "R-MMU-2559582", "R-DDI-174048", "R-RNO-179409", "R-RNO-174184", "R-MMU-141430", "R-RNO-176408", "R-DDI-141430", "R-BTA-69017", "R-BTA-176408", "R-RNO-174084", "R-HSA-174048", "R-DRE-176409", "R-RNO-2467813", "R-HSA-179409", "R-DRE-176412", "R-RNO-983168", "R-HSA-174154", "R-DDI-176408", "R-HSA-8853884", "R-HSA-2467813", "R-BTA-176412", "R-MMU-179409", "R-RNO-174178", "R-HSA-2559582", "R-DDI-174178", "R-HSA-174184", "R-MMU-174178", "R-RNO-176407", "R-MMU-174048", "R-DRE-983168", "R-BTA-2467813", "R-BTA-174154", "R-DRE-176407", "R-DDI-176409", "R-DRE-2559582", "R-DDI-2467813", "R-DDI-176412", "R-BTA-174184", "R-HSA-174084", "R-DRE-176408", "R-HSA-176407", "R-BTA-174178", "R-BTA-176407", "R-DDI-69017", "R-DRE-174178", "R-HSA-176412", "R-MMU-176408", "R-DRE-174154", "R-BTA-174048", "R-DRE-174084", "R-HSA-983168", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-RNO-68867", "R-DDI-174184", "R-HSA-69017", "R-DRE-179409", "R-MMU-983168", "R-RNO-69017", "R-DRE-68867", "R-DDI-174154"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome 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"R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-DRE-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-RNO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-RNO-176412:r:Phosphorylation of the APC/C", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9687136:r:Aberrant 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degradation of mitotic proteins", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-176412:r:Phosphorylation of the APC/C", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DRE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DRE-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DRE-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-68867:r:Assembly of the pre-replicative complex", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin"], "type": "Family"}, "IPR018861": {"description": "Transmembrane protein 201, C-terminal", "go_ids": ["GO:0005637"], "go_terms": ["GO:0005637:nuclear inner membrane:C"], "name": "TMEM201_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018862": {"description": "Eukaryotic translation initiation factor 4E binding protein", "go_ids": [], "go_terms": [], "name": "eIF4E-T", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018864": {"description": "Nucleoporin Nup188, N-terminal", "go_ids": ["GO:0017056"], "go_terms": ["GO:0017056:structural constituent of nuclear pore:F"], "name": "Nucleoporin_Nup188_N", "pathway_ids": ["R-XTR-4615885", "R-HSA-180910", "R-HSA-9705671", "R-XTR-9615933", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-XTR-159236", "R-DME-4085377", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-9615933", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-MMU-4085377", "R-MMU-4551638", "R-HSA-3371453", "R-HSA-165054", "R-DME-4615885", "R-HSA-4570464", "R-XTR-170822", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-XTR-191859", "R-DME-3371453", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-DME-4551638", "R-MMU-3301854", "R-XTR-3371453", "R-DME-159227", "R-HSA-4085377", "R-HSA-168325", "R-XTR-4085377", "R-XTR-3301854", "R-HSA-9609690", "R-MMU-170822", "R-MMU-159236", "R-HSA-159231", "R-DME-159230", "R-DME-9615933", "R-HSA-3232142", "R-HSA-3301854", "R-DME-3301854", "R-HSA-9615933", "R-MMU-159227", "R-HSA-5619107", "R-HSA-159236", "R-MMU-3108214", "R-XTR-3108214", "R-HSA-180746"], "pathways": ["R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-XTR-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an 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shock response", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-XTR-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP 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{"description": "Zn-cluster domain", "go_ids": [], "go_terms": [], "name": "Zn-cluster-dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018873": {"description": "KilA-N, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "KilA-N_DNA-bd_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018874": {"description": "Bacteriophage Mx8, p63, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_Mx8_p63_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018875": {"description": "Antirepressor protein ant, N-terminal", "go_ids": [], "go_terms": [], "name": "Antirepressor_Ant_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018876": {"description": "Bacteriophage P22, antirepressor protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_P22_antirepressor_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018877": {"description": "Bacteriophage P22, Orf201, C-terminal", "go_ids": [], "go_terms": [], "name": 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["R-DME-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-8849932:r:Synaptic adhesion-like molecules"], "type": "Domain"}, "IPR018883": {"description": "Delta carbonic anhydrase", "go_ids": [], "go_terms": [], "name": "Delta_CA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018884": {"description": "Glutamate [NMDA] receptor, epsilon subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "NMDAR2_C", "pathway_ids": ["R-RNO-5673001", "R-CFA-9609736", "R-HSA-9617324", "R-MMU-9609736", "R-MMU-8849932", "R-MMU-438066", "R-HSA-9032500", "R-HSA-8849932", "R-RNO-438066", "R-RNO-9609736", "R-HSA-442982", "R-HSA-3928662", "R-HSA-6794361", "R-HSA-5673001", "R-CFA-3928662", "R-HSA-9609736", "R-CFA-8849932", "R-HSA-438066", "R-HSA-9620244", "R-MMU-3928662", "R-RNO-3928662", "R-CFA-5673001", "R-HSA-9022699", "R-CFA-438066", "R-RNO-8849932", "R-MMU-5673001"], "pathways": ["R-RNO-5673001:r:RAF/MAP kinase cascade", "R-CFA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9620244:r:Long-term potentiation", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-MMU-5673001:r:RAF/MAP kinase cascade"], "type": "Domain"}, "IPR018885": {"description": "mRNA-binding domain", "go_ids": [], "go_terms": [], "name": "mRNA-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018886": {"description": "Uncharacterised domain UPF0547", "go_ids": [], "go_terms": [], "name": "UPF0547", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018887": {"description": "Myeloid-derived growth factor", "go_ids": [], "go_terms": [], "name": "MYDGF", "pathway_ids": ["R-HSA-381038"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes"], "type": "Family"}, "IPR018888": {"description": "Uncharacterised protein family UPF0561", "go_ids": [], "go_terms": [], "name": "UPF0561", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018889": {"description": "Arpin", "go_ids": ["GO:0051126"], "go_terms": ["GO:0051126:negative regulation of actin nucleation:P"], "name": "Arpin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018890": {"description": "FAM171", "go_ids": [], "go_terms": [], "name": "FAM171", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018891": {"description": "Abortive phage infection protein, C-terminal", "go_ids": [], "go_terms": [], "name": "AIPR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018892": {"description": "Retro-transposon transporting motif", "go_ids": [], "go_terms": [], "name": "Retro-transposon_transp_CS", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-MMU-4570464", "R-RNO-3301854", "R-RNO-3108214", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-159230", "R-HSA-159227", "R-HSA-159230", "R-MMU-4085377", "R-MMU-4551638", "R-HSA-168333", "R-RNO-159230", "R-HSA-3371453", "R-RNO-191859", "R-HSA-165054", "R-HSA-4570464", "R-RNO-159236", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-MMU-3301854", "R-HSA-4085377", "R-HSA-168325", "R-MMU-170822", "R-HSA-9609690", "R-RNO-159227", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-RNO-4551638", "R-MMU-159227", "R-RNO-4085377", "R-RNO-170822", "R-HSA-5619107", "R-RNO-159231", "R-RNO-4570464", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-191859:r:snRNP Assembly", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Conserved_site"}, "IPR018893": {"description": "Type VIII secretion system, CsgF", "go_ids": [], "go_terms": [], "name": "T8SS_CsgF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018894": {"description": "Protein of unknown function DUF2471", "go_ids": [], "go_terms": [], "name": "DUF2471", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018895": {"description": "Protein of unknown function DUF2474", "go_ids": [], "go_terms": [], "name": "DUF2474", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018897": {"description": "Plasmid conjugative transfer protein PilI", "go_ids": [], "go_terms": [], "name": "Plasmid_conjug_transfer_PilI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018898": {"description": "Plasmid conjugative transfer entry exclusion protein TraS", "go_ids": [], "go_terms": [], "name": "Eex_TraS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018899": {"description": "Conjugative transposon, TraO", "go_ids": [], "go_terms": [], "name": "Conjug_transposon_Tra0", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018900": {"description": "Curli assembly protein CsgE", "go_ids": [], "go_terms": [], "name": "Curli_CsgE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018901": {"description": "Spore coat protein CotE", "go_ids": [], "go_terms": [], "name": "Spore_coat_CotE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018902": {"description": "Ciliary microtubule inner protein 2A-C-like domain", "go_ids": [], "go_terms": [], "name": "CMI2A-C-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018903": {"description": "Proline-rich protein 23", "go_ids": [], "go_terms": [], "name": "PRR23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018904": {"description": "Uncharacterised protein family UPF0574", "go_ids": [], "go_terms": [], "name": "UPF0574", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018905": {"description": "Alpha-galactosidase, NEW3 domain", "go_ids": [], "go_terms": [], "name": "A-galactase_NEW3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018906": {"description": "DNA integrity scanning, DisA, linker region", "go_ids": [], "go_terms": [], "name": "DNA_integrity_scan_DisA_link", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018907": {"description": "Spindle body associated protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Spindle_body_associated_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018908": {"description": "Putative transmembrane family 234", "go_ids": [], "go_terms": [], "name": "TMEM234", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018909": {"description": "Endo-1,3(4)-beta-glucanase 1, carbohydrate binding", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "Eng1_septum", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018910": {"description": "Lipoprotein LpqB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LpqB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018911": {"description": "Bacterial spore germination, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Gmad2_Ig-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018912": {"description": "Protein of unknown function DUF2478", "go_ids": [], "go_terms": [], "name": "DUF2478", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018913": {"description": "BppU, N-terminal", "go_ids": [], "go_terms": [], "name": "BppU_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018914": {"description": "Protein of unknown function DUF2480", "go_ids": [], "go_terms": [], "name": "DUF2480", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018915": {"description": "Bacteriophage A118, Gp45", "go_ids": [], "go_terms": [], "name": "Phage_A118_Gp45", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018916": {"description": "Protein of unknown function DUF2481", "go_ids": [], "go_terms": [], "name": "DUF2481", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018917": {"description": "Protein of unknown function DUF2482", "go_ids": [], "go_terms": [], "name": "DUF2482", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018918": {"description": "Protein of unknown function DUF2483", "go_ids": [], "go_terms": [], "name": "DUF2483", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018919": {"description": "Protein of unknown function DUF2484", "go_ids": [], "go_terms": [], "name": "DUF2484", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018920": {"description": "ESAT-6 secretion machinery protein EssA/YueC", "go_ids": [], "go_terms": [], "name": "EssA/YueC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018922": {"description": "NAD(P)H-quinone oxidoreductase subunit M", "go_ids": ["GO:0016655"], "go_terms": ["GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F"], "name": "NdhM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018923": {"description": "Phage tail assembly chaperone protein Gp14", "go_ids": [], "go_terms": [], "name": "Phage_TAC_8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018924": {"description": "Protein of unknown function DUF2486", "go_ids": [], "go_terms": [], "name": "DUF2486", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018925": {"description": "PBSX phage terminase small subunit-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "XtmA-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018926": {"description": "Gp23", "go_ids": [], "go_terms": [], "name": "Gp23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018927": {"description": "Toxin co-regulated pilus biosynthesis protein Q, C-terminal", "go_ids": [], "go_terms": [], "name": "Pilus_synth_Q_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018928": {"description": "HAP2 domain", "go_ids": [], "go_terms": [], "name": "HAP2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018929": {"description": "Domain of unknown function DUF2510", "go_ids": [], "go_terms": [], "name": "DUF2510", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018930": {"description": "Late embryogenesis abundant protein, LEA-18", "go_ids": [], "go_terms": [], "name": "LEA-18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018931": {"description": "Domain of unknown function DUF2520", "go_ids": [], "go_terms": [], "name": "DUF2520", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018932": {"description": "Salivary thrombin inhibitor anophelin, mosquito", "go_ids": [], "go_terms": [], "name": "Thrombin_inhibitor_anophelin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018933": {"description": "Netrin module, non-TIMP type", "go_ids": [], "go_terms": [], "name": "Netrin_module_non-TIMP", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-HSA-201681", "R-HSA-2243919", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-2243919", "R-HSA-418886", "R-MMU-166663", "R-BTA-6798695", "R-HSA-418885", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-HSA-1650814", "R-MMU-2243919", "R-RNO-977606", "R-RNO-418594", "R-BTA-8957275", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-525793", "R-HSA-381426", "R-BTA-977606", "R-HSA-3772470", "R-RNO-1650814", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-5083635", "R-HSA-428542", "R-HSA-9660826", "R-HSA-3000171", "R-HSA-373752", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-HSA-5173214", "R-MMU-1650814", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-418890", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-HSA-376172", "R-MMU-373752", "R-RNO-6798695", "R-BTA-375276"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-2243919:r:Crosslinking of collagen fibrils", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-418594:r:G alpha (i) signalling events", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-525793:r:Myogenesis", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-373752:r:Netrin-1 signaling", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-376172:r:DSCAM interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors"], "type": "Domain"}, "IPR018934": {"description": "RIO-type domain", "go_ids": ["GO:0003824", "GO:0005524"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0005524:ATP binding:F"], "name": "RIO_dom", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-SPO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR018937": {"description": "Membrane magnesium transporter", "go_ids": [], "go_terms": [], "name": "MMgT", "pathway_ids": ["R-HSA-5223345"], "pathways": ["R-HSA-5223345:r:Miscellaneous transport and binding events"], "type": "Family"}, "IPR018939": {"description": "Autophagy-related protein 27", "go_ids": [], "go_terms": [], "name": "Autophagy-rel_prot_27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018940": {"description": "Elongation factor 1 beta central acidic region, eukaryote", "go_ids": [], "go_terms": [], "name": "EF-1_beta_acid_region_euk", "pathway_ids": ["R-MMU-156842", "R-SSC-156842", "R-BTA-156842", "R-RNO-156842", "R-HSA-156842", "R-XTR-156842", "R-SCE-156842", "R-DME-156842", "R-DDI-156842", "R-SPO-156842"], "pathways": ["R-MMU-156842:r:Eukaryotic Translation Elongation", "R-SSC-156842:r:Eukaryotic Translation Elongation", "R-BTA-156842:r:Eukaryotic Translation Elongation", "R-RNO-156842:r:Eukaryotic Translation Elongation", "R-HSA-156842:r:Eukaryotic Translation Elongation", "R-XTR-156842:r:Eukaryotic Translation Elongation", "R-SCE-156842:r:Eukaryotic Translation Elongation", "R-DME-156842:r:Eukaryotic Translation Elongation", "R-DDI-156842:r:Eukaryotic Translation Elongation", "R-SPO-156842:r:Eukaryotic Translation Elongation"], "type": "Domain"}, "IPR018941": {"description": "Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal", "go_ids": ["GO:0004714", "GO:0005524", "GO:0005886", "GO:0006468", "GO:0007169"], "go_terms": ["GO:0004714:transmembrane receptor protein tyrosine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0005886:plasma membrane:C", "GO:0006468:protein phosphorylation:P", "GO:0007169:cell surface receptor protein tyrosine kinase signaling pathway:P"], "name": "Tyr_kin_Tie2_Ig-like_dom-1_N", "pathway_ids": ["R-HSA-210993", "R-BTA-5673001", "R-BTA-210993", "R-MMU-210993", "R-MMU-5673001", "R-DRE-5673001", "R-DRE-210993", "R-HSA-5673001"], "pathways": ["R-HSA-210993:r:Tie2 Signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-210993:r:Tie2 Signaling", "R-MMU-210993:r:Tie2 Signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-DRE-210993:r:Tie2 Signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Domain"}, "IPR018942": {"description": "Seminal vesicle protein repeat", "go_ids": [], "go_terms": [], "name": "Seminal_vesicle_protein_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR018943": {"description": "Oligosaccaryltransferase", "go_ids": [], "go_terms": [], "name": "Oligosaccaryltransferase", "pathway_ids": ["R-RNO-9931295", "R-MMU-9931295", "R-RNO-9768727", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9918432", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-9931295"], "pathways": ["R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Family"}, "IPR018944": {"description": "DNA polymerase lambda, fingers domain", "go_ids": ["GO:0034061", "GO:0003677"], "go_terms": ["GO:0034061:DNA polymerase activity:F", "GO:0003677:DNA binding:F"], "name": "DNA_pol_lambd_fingers_domain", "pathway_ids": ["R-BTA-5649702", "R-BTA-110373", "R-MMU-5649702", "R-MMU-5693571", "R-BTA-5689880", "R-DRE-110381", "R-HSA-5689880", "R-DRE-5649702", "R-DRE-110373", "R-RNO-110362", "R-MMU-110381", "R-HSA-5649702", "R-DRE-110362", "R-RNO-110381", "R-MMU-5689880", "R-MMU-110362", "R-BTA-5651801", "R-BTA-73930", "R-HSA-110373", "R-DRE-5689880", "R-MMU-5651801", "R-HSA-110362", "R-BTA-110381", "R-HSA-5651801", "R-BTA-110362", "R-RNO-5693571", "R-RNO-5689880", "R-RNO-5649702", "R-MMU-110373", "R-HSA-5693571", "R-RNO-73930", "R-HSA-110381", "R-MMU-73930", "R-RNO-5651801", "R-DRE-5651801", "R-DRE-73930", "R-HSA-73930", "R-RNO-110373"], "pathways": ["R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-BTA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DRE-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "type": "Domain"}, "IPR018946": {"description": "PhoD-like phosphatase, metallophosphatase domain", "go_ids": [], "go_terms": [], "name": "PhoD-like_MPP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018947": {"description": "Neuromodulin, N-terminal", "go_ids": [], "go_terms": [], "name": "Neuromodulin_N", "pathway_ids": ["R-RNO-373760", "R-MMU-373760", "R-HSA-373760", "R-BTA-373760"], "pathways": ["R-RNO-373760:r:L1CAM interactions", "R-MMU-373760:r:L1CAM interactions", "R-HSA-373760:r:L1CAM interactions", "R-BTA-373760:r:L1CAM interactions"], "type": "Domain"}, "IPR018948": {"description": "GTP-binding protein TrmE, N-terminal", "go_ids": [], "go_terms": [], "name": "GTP-bd_TrmE_N", "pathway_ids": ["R-HSA-6787450"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR018950": {"description": "Disulphide bond isomerase, DsbC/G, N-terminal", "go_ids": [], "go_terms": [], "name": "DiS-bond_isomerase_DsbC/G_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018951": {"description": "Fumarase C, C-terminal", "go_ids": ["GO:0006099", "GO:0016829"], "go_terms": ["GO:0006099:tricarboxylic acid cycle:P", "GO:0016829:lyase activity:F"], "name": "Fumarase_C_C", "pathway_ids": ["PWY-8086", "PWY-7254", "PWY-6728", "PWY-5913", "PWY-7384", "PWY-561", "PWY-5690", "PWY-5392", "PWY-6969", "R-DRE-9837999", "R-DDI-9837999", "R-MMU-9837999", "R-SPO-71403", "R-CEL-71403", "R-CEL-9837999", "R-SPO-9837999", "R-MMU-71403", "R-SCE-71403", "R-SCE-9837999", "R-HSA-9837999", "R-DDI-71403", "R-RNO-71403", "R-RNO-9837999", "R-DRE-71403", "R-HSA-71403"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-6728:t:methylaspartate cycle", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Domain"}, "IPR018952": {"description": "2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal", "go_ids": [], "go_terms": [], "name": "2-5-oligoAdlate_synth_1_dom2/C", "pathway_ids": ["R-HSA-8983711", "R-RNO-8983711", "R-HSA-909733", "R-HSA-877300", "R-HSA-9833110", "R-MMU-8983711"], "pathways": ["R-HSA-8983711:r:OAS antiviral response", "R-RNO-8983711:r:OAS antiviral response", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-8983711:r:OAS antiviral response"], "type": "Domain"}, "IPR018953": {"description": "AMP nucleoside phosphorylase, N-terminal", "go_ids": [], "go_terms": [], "name": "AMP_nucleoside_Pase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018954": {"description": "Beta-galactosidase, domain 2", "go_ids": [], "go_terms": [], "name": "Betagal_dom2", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR018955": {"description": "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal", "go_ids": [], "go_terms": [], "name": "BCDHK/PDK_N", "pathway_ids": ["R-DME-204174", "R-BTA-70895", "R-MMU-9837999", "R-HSA-204174", "R-SPO-5362517", "R-CEL-9837999", "R-RNO-204174", "R-DME-9837999", "R-CEL-5362517", "R-CEL-204174", "R-HSA-70895", "R-RNO-9837999", "R-HSA-9841922", "R-RNO-70895", "R-MMU-204174", "R-MMU-70895", "R-SPO-9837999", "R-MMU-5362517", "R-HSA-9912481", "R-HSA-9837999", "R-HSA-5362517", "R-DME-5362517", "R-SPO-204174", "R-RNO-5362517"], "pathways": ["R-DME-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-DME-9837999:r:Mitochondrial protein degradation", "R-CEL-5362517:r:Signaling by Retinoic Acid", "R-CEL-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-DME-5362517:r:Signaling by Retinoic Acid", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-5362517:r:Signaling by Retinoic Acid"], "type": "Domain"}, "IPR018957": {"description": "Zinc finger, C3HC4 RING-type", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Znf_C3HC4_RING-type", "pathway_ids": ["R-BTA-8866654", "R-RNO-975138", "R-MMU-3108214", "R-BTA-9833482", "R-DRE-937039", "R-HSA-9680350", "R-HSA-9699150", "R-DRE-5693607", "R-HSA-5685942", "R-HSA-1059683", "R-RNO-937072", "R-HSA-933542", "R-RNO-1257604", "R-RNO-450321", "R-MMU-5357956", "R-DRE-983168", "R-MMU-5693565", "R-HSA-5357905", "R-RNO-9645460", "R-RNO-5685938", "R-HSA-912446", "R-MMU-5218900", "R-MMU-5693579", "R-SCE-5205685", "R-HSA-5693568", "R-MMU-5693607", "R-HSA-9701192", "R-RNO-937041", "R-HSA-9706369", "R-BTA-3134975", "R-MMU-382556", "R-MMU-912631", "R-MMU-2173789", "R-DME-8866654", "R-MMU-3899300", "R-HSA-5654726", "R-MMU-5675482", "R-MMU-9706369", "R-HSA-9709603", "R-HSA-6807004", "R-CEL-9931269", "R-DME-9013422", "R-BTA-9013422", "R-RNO-5685942", "R-MMU-5654726", "R-HSA-5693571", "R-HSA-933541", "R-DRE-975144", "R-HSA-5357956", "R-HSA-8856825", "R-MMU-5654727", "R-HSA-877300", "R-MMU-6807004", "R-BTA-5693571", "R-HSA-140534", "R-HSA-5693579", "R-HSA-9725370", "R-HSA-8875360", "R-HSA-8849469", "R-BTA-9909505", "R-MMU-182971", "R-MMU-1433559", "R-HSA-9825895", "R-BTA-983168", "R-HSA-9013422", "R-RNO-9020702", "R-HSA-1606341", "R-HSA-9920588", "R-HSA-5693616", "R-HSA-1834941", "R-HSA-8856828", "R-MMU-5689901", "R-MMU-2122948", "R-RNO-3108214", "R-MMU-5693616", "R-HSA-6796648", "R-MMU-1295596", "R-HSA-75893", "R-DDI-8951664", "R-MMU-9833482", "R-HSA-9709570", "R-HSA-5693607", "R-MMU-9013422", "R-CEL-382556", "R-RNO-202424", "R-RNO-205043", "R-HSA-9635465", "R-MMU-5654732", "R-BTA-5693607", "R-MMU-5693568", "R-DRE-9020702", "R-HSA-1266695", "R-HSA-2173789", "R-HSA-9663199", "R-MMU-75893", "R-DDI-5658442", "R-RNO-5693579", "R-HSA-5675482", "R-RNO-209560", "R-HSA-5654732", "R-RNO-5693607", "R-HSA-5678895", "R-HSA-9755511", "R-RNO-9931269", "R-RNO-69473", "R-HSA-5357786", "R-DRE-209543", "R-HSA-9704331", "R-RNO-450302", "R-MMU-9931269", "R-HSA-3134975", "R-RNO-445989", "R-HSA-8948751", "R-RNO-168638", "R-DRE-5693565", "R-RNO-5693616", "R-RNO-5689896", "R-BTA-1169408", "R-RNO-983168", "R-HSA-5693554", "R-HSA-5654733", "R-MMU-5693571", "R-HSA-3371378", "R-DRE-937072", "R-HSA-5689901", "R-DRE-382556", "R-MMU-5676594", "R-BTA-69473", "R-HSA-3108214", "R-DDI-9755511", "R-MMU-8856825", "R-HSA-901032", "R-HSA-2122948", "R-HSA-9704646", "R-HSA-5676594", "R-MMU-9755511", "R-HSA-1221632", "R-BTA-3108214", "R-HSA-8953750", "R-DRE-450302", "R-HSA-1169408", "R-HSA-9909505", "R-HSA-198323", "R-HSA-6804758", "R-MMU-4085377", "R-HSA-1236382", "R-DRE-975163", "R-DRE-209560", "R-SPO-983168", "R-RNO-6804756", "R-DRE-5689896", "R-HSA-9833110", "R-SCE-983168", "R-DRE-168638", "R-HSA-5685938", "R-RNO-937039", "R-DRE-5689880", "R-MMU-5357786", "R-MMU-8849469", "R-HSA-8948747", "R-RNO-166058", "R-HSA-382556", "R-HSA-4085377", "R-MMU-5685942", "R-HSA-983168", "R-XTR-9013424", "R-MMU-1169408", "R-RNO-975871", "R-HSA-9706377", "R-HSA-5213460", "R-HSA-5668541", "R-DDI-983168", "R-MMU-1059683", "R-RNO-5607764", "R-HSA-5687128", "R-XTR-983168", "R-MMU-983168", "R-MMU-5654733", "R-HSA-3899300", "R-MMU-9758274", "R-MMU-4755510", "R-RNO-2871837", "PWY-7511", "R-MMU-8856828", "R-MMU-9909505", "R-RNO-9758274", "R-HSA-5218900", "R-HSA-4755510", "R-HSA-9833482", "R-MMU-198323", "R-HSA-8951664", "R-HSA-5689880", "R-BTA-9755511", "R-RNO-5693565", "R-HSA-912631", "R-MMU-6804756", "R-RNO-382556", "R-HSA-5693565", "R-RNO-5689901", "R-RNO-8866654", "R-RNO-193692", "R-MMU-5685938", "R-MMU-8948751", "R-DRE-445989", "R-MMU-69473", "R-MMU-5689880", "R-DRE-5693571", "R-RNO-6811558", "R-MMU-5668541", "R-HSA-9693928", "R-MMU-3371378", "R-RNO-937042", "R-SCE-9646399", "R-HSA-9616222", "R-DRE-937042", "R-MMU-8866654", "R-DRE-450321", "R-HSA-3270619", "R-HSA-9931269", "R-DRE-9931269", "R-HSA-182971", "R-HSA-5654727", "R-RNO-975144", "R-MMU-3270619", "R-HSA-69473", "R-RNO-975163", "R-HSA-9758274", "R-MMU-3134975", "R-BTA-5693565", "R-RNO-5693571", "R-HSA-9609690", "R-HSA-8934593", "R-HSA-5637810", "R-RNO-209543", "R-RNO-5689880", "R-HSA-69416", "R-HSA-8866654", "R-HSA-3232142", "R-MMU-69416", "R-HSA-1433559", "R-HSA-6804756", "R-HSA-1295596", "R-DDI-4641258", "R-MMU-5357905", "R-RNO-5693568"], "pathways": ["R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-9833482:r:PKR-mediated signaling", "R-DRE-937039:r:IRAK1 recruits IKK complex", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-9699150:r:Defective DNA double strand break response due to BARD1 loss of function", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-1059683:r:Interleukin-6 signaling", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human 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activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-3371378:r:Regulation by c-FLIP", "R-DRE-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5689901:r:Metalloprotease DUBs", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating 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"R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DRE-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DRE-209560:r:NF-kB is activated and signals survival", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-HSA-9833110:r:RSV-host interactions", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-8948747:r:Regulation of PTEN localization", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-9013424:r:RHOV GTPase cycle", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-983168:r:Antigen processing: 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"R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-3371378:r:Regulation by c-FLIP", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-SCE-9646399:r:Aggrephagy", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-DRE-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DRE-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DRE-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-182971:r:EGFR downregulation", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-69416:r:Dimerization of procaspase-8", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-69416:r:Dimerization of procaspase-8", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-DDI-4641258:r:Degradation of DVL", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates"], "type": "Domain"}, "IPR018958": {"description": "Knr4/Smi1-like domain", "go_ids": [], "go_terms": [], "name": "Knr4/Smi1-like_dom", "pathway_ids": ["R-HSA-8955332"], "pathways": ["R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Domain"}, "IPR018959": {"description": "Domain of unknown function DUF1989", "go_ids": [], "go_terms": [], "name": "DUF1989", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018960": {"description": "Domain of unknown function DUF1990", "go_ids": [], "go_terms": [], "name": "DUF1990", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018961": {"description": "DnaJ homologue, subfamily C, member 28, conserved domain", "go_ids": [], "go_terms": [], "name": "DnaJ_homolog_subfam-C_membr-28", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018962": {"description": "Domain of unknown function DUF1995", "go_ids": [], "go_terms": [], "name": "DUF1995", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018963": {"description": "Mycobacteriophage D29-like, Gp19", "go_ids": [], "go_terms": [], "name": "Mycophage_D29_Gp19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018964": {"description": "Bacteriophage phiJL001, Gp84, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_phiJL001_Gp84_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018965": {"description": "Ubiquitin-activating enzyme E1, C-terminal", "go_ids": [], "go_terms": [], "name": "Ub-activating_enz_E1_C", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-MMU-9909505", "R-HSA-168928", "R-DDI-936440", "R-HSA-9918485", "R-MMU-5656169", "R-RNO-8866652", "R-HSA-936440", "R-HSA-983168", "R-HSA-1169408", "R-MMU-8866652", "R-MMU-1169408", "R-HSA-9909505", "R-DDI-983168", "R-HSA-8866652", "R-DDI-9909505", "R-BTA-8866652", "R-MMU-983168", "R-SPO-983168", "R-RNO-983168", "R-SCE-983168", "R-HSA-5656169", "R-DDI-1169408", "R-DDI-8866652"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "type": "Domain"}, "IPR018966": {"description": "VTC domain", "go_ids": [], "go_terms": [], "name": "VTC_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018967": {"description": "Iron-binding zinc finger, CDGSH type", "go_ids": ["GO:0043231", "GO:0051537"], "go_terms": ["GO:0043231:intracellular membrane-bounded organelle:C", "GO:0051537:2 iron, 2 sulfur cluster binding:F"], "name": "FeS-contain_CDGSH-typ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018968": {"description": "Phasin", "go_ids": [], "go_terms": [], "name": "Phasin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018969": {"description": "Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, C-terminal", "go_ids": ["GO:0005975", "GO:0016832"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016832:aldehyde-lyase activity:F"], "name": "Xul5P/Fru6P_PKetolase_C", "pathway_ids": ["PWY-7089", "PWY-7085"], "pathways": ["PWY-7089:t:taxiphyllin bioactivation", "PWY-7085:t:triethylamine degradation"], "type": "Domain"}, "IPR018970": {"description": "Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, N-terminal", "go_ids": [], "go_terms": [], "name": "Xul5P/Fru6P_PKetolase_N", "pathway_ids": ["PWY-7089", "PWY-7085"], "pathways": ["PWY-7089:t:taxiphyllin bioactivation", "PWY-7085:t:triethylamine degradation"], "type": "Domain"}, "IPR018971": {"description": "Protein of unknown function DUF1997", "go_ids": [], "go_terms": [], "name": "DUF1997", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018972": {"description": "Sas10 C-terminal domain", "go_ids": [], "go_terms": [], "name": "Sas10_C_dom", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR018973": {"description": "MrfA-like Zn-binding domain", "go_ids": [], "go_terms": [], "name": "MZB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018974": {"description": "Tex-like protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Tex-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018975": {"description": "Pseudomurein-binding repeat", "go_ids": [], "go_terms": [], "name": "Pseudomurein-binding_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR018976": {"description": "Imelysin-like domain", "go_ids": [], "go_terms": [], "name": "Imelysin-like", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR018977": {"description": "NurA domain", "go_ids": [], "go_terms": [], "name": "NurA_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018978": {"description": "Ribosome maturation protein SDO1/SBDS, central domain", "go_ids": ["GO:0042254"], "go_terms": ["GO:0042254:ribosome biogenesis:P"], "name": "SDO1/SBDS_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018979": {"description": "FERM, N-terminal", "go_ids": [], "go_terms": [], "name": "FERM_N", "pathway_ids": ["R-MMU-182971", "R-RNO-9035034", "R-MMU-8980692", "R-HSA-166016", "R-RNO-8980692", "R-RNO-9013149", "R-MMU-9013148", "R-DDI-114608", "R-HSA-1660499", "R-HSA-6794361", "R-DRE-983168", "R-DME-2029482", "R-BTA-6794361", "R-HSA-9662360", "R-HSA-9035034", "R-MMU-373752", "R-HSA-9013148", "R-HSA-399955", "R-HSA-9696273", "R-RNO-373752", "R-BTA-373752", "R-CEL-182971", "R-CFA-6794361", "R-RNO-8866427", "R-MMU-9035034", "R-MMU-437239", "R-HSA-182971", "R-HSA-399719", "R-RNO-437239", "R-CEL-5675221", "R-DME-437239", "R-HSA-9696270", "R-MMU-399955", "R-HSA-9662361", "R-MMU-6794361", "R-DME-5627123", "R-HSA-437239", "R-HSA-9031525", "R-HSA-8950505", "R-MMU-166016", "R-RNO-9013148", "R-HSA-373752", "R-HSA-2029482", "R-HSA-983168", "R-RNO-399719", "R-MMU-2029482", "R-MMU-1660499", "R-HSA-9696264", "R-HSA-9008059", "R-HSA-9013149", "R-HSA-8866427", "R-HSA-8980692", "R-HSA-5627123", "R-MMU-8866427", "R-MMU-9013149", "R-MMU-983168", "R-HSA-9022699", "R-DME-6794361", "R-MMU-5627123", "R-MMU-9696270", "R-MMU-9696264", "R-RNO-6794361", "R-RNO-983168", "R-MMU-9696273", "R-HSA-9725370", "R-MMU-399719", "R-DME-373752", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-MMU-182971:r:EGFR downregulation", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-DDI-114608:r:Platelet degranulation", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-373752:r:Netrin-1 signaling", "R-BTA-373752:r:Netrin-1 signaling", "R-CEL-182971:r:EGFR downregulation", "R-CFA-6794361:r:Neurexins and neuroligins", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-437239:r:Recycling pathway of L1", "R-HSA-182971:r:EGFR downregulation", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-RNO-437239:r:Recycling pathway of L1", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-DME-6794361:r:Neurexins and neuroligins", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-DME-373752:r:Netrin-1 signaling", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR018980": {"description": "FERM, C-terminal PH-like domain", "go_ids": [], "go_terms": [], "name": "FERM_PH-like_C", "pathway_ids": ["R-MMU-182971", "R-RNO-9035034", "R-MMU-8980692", "R-HSA-166016", "R-RNO-8980692", "R-DME-451806", "R-RNO-9013149", "R-MMU-9013148", "R-HSA-1660499", "R-HSA-6794361", "R-DRE-983168", "R-DME-2029482", "R-BTA-6794361", "R-HSA-9662360", "R-HSA-9035034", "R-MMU-373752", "R-HSA-9013148", "R-HSA-399955", "R-HSA-9696273", "R-RNO-373752", "R-BTA-373752", "R-CEL-182971", "R-CFA-6794361", "R-RNO-8866427", "R-MMU-9035034", "R-MMU-437239", "R-HSA-182971", "R-HSA-399719", "R-RNO-437239", "R-CEL-5675221", "R-DME-437239", "R-HSA-9696270", "R-MMU-399955", "R-HSA-9662361", "R-MMU-6794361", "R-DME-5627123", "R-HSA-437239", "R-HSA-9031525", "R-HSA-8950505", "R-MMU-166016", "R-RNO-9013148", "R-HSA-373752", "R-HSA-2029482", "R-HSA-983168", "R-RNO-399719", "R-MMU-2029482", "R-MMU-1660499", "R-HSA-9696264", "R-HSA-9008059", "R-HSA-9013149", "R-HSA-8866427", "R-HSA-8980692", "R-HSA-5627123", "R-MMU-8866427", "R-MMU-9013149", "R-MMU-983168", "R-HSA-9022699", "R-DME-6794361", "R-MMU-5627123", "R-MMU-9696270", "R-MMU-9696264", "R-RNO-6794361", "R-RNO-983168", "R-MMU-9696273", "R-HSA-9725370", "R-MMU-399719", "R-DME-373752", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-MMU-182971:r:EGFR downregulation", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-8980692:r:RHOA GTPase cycle", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-373752:r:Netrin-1 signaling", "R-BTA-373752:r:Netrin-1 signaling", "R-CEL-182971:r:EGFR downregulation", "R-CFA-6794361:r:Neurexins and neuroligins", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-437239:r:Recycling pathway of L1", "R-HSA-182971:r:EGFR downregulation", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-RNO-437239:r:Recycling pathway of L1", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-DME-6794361:r:Neurexins and neuroligins", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-DME-373752:r:Netrin-1 signaling", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR018981": {"description": "Outer membrane porin G", "go_ids": [], "go_terms": [], "name": "Outer_membrane_porin_G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018982": {"description": "RQC domain", "go_ids": ["GO:0006260", "GO:0006281", "GO:0043138"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0006281:DNA repair:P", "GO:0043138:3'-5' DNA helicase activity:F"], "name": "RQC_domain", "pathway_ids": ["R-HSA-3108214", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-174414", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-HSA-174437", "R-HSA-9709570", "R-MMU-174414", "R-HSA-5693607", "R-HSA-912446", "R-MMU-174437", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-DME-3108214", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-69473", "R-MMU-5685942", "R-HSA-9709603", "R-HSA-6804756", "R-HSA-9704331", "R-MMU-3108214", "R-HSA-5693554", "R-HSA-5693579"], "pathways": ["R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-912446:r:Meiotic recombination", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange"], "type": "Domain"}, "IPR018983": {"description": "U3 small nucleolar RNA-associated protein 15, C-terminal", "go_ids": ["GO:0005730", "GO:0006364"], "go_terms": ["GO:0005730:nucleolus:C", "GO:0006364:rRNA processing:P"], "name": "U3_snoRNA-assocProt_15_C", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-SPO-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR018984": {"description": "Histidine kinase, N-terminal", "go_ids": [], "go_terms": [], "name": "Histidine_kinase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018987": {"description": "Protein of unknown function DUF1999", "go_ids": [], "go_terms": [], "name": "DUF1999", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018988": {"description": "Protein of unknown function DUF2000", "go_ids": [], "go_terms": [], "name": "DUF2000", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018989": {"description": "Phage tail tube protein", "go_ids": [], "go_terms": [], "name": "DUF2001", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018990": {"description": "Proteinase inhibitor I42, chagasin", "go_ids": [], "go_terms": [], "name": "Prot_inh_I42_chagasin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018992": {"description": "Thrombin light chain", "go_ids": ["GO:0004252", "GO:0005576", "GO:0006508", "GO:0007596"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0005576:extracellular region:C", "GO:0006508:proteolysis:P", "GO:0007596:blood coagulation:P"], "name": "Thrombin_light_chain", "pathway_ids": ["R-MMU-416476", "R-HSA-9657688", "R-HSA-159782", "R-MMU-159740", "R-HSA-375276", "R-MMU-76009", "R-HSA-140837", "R-RNO-159782", "R-RNO-140875", "R-HSA-416476", "R-MMU-375276", "R-RNO-977606", "R-RNO-140837", "R-HSA-76009", "R-MMU-456926", "R-HSA-977606", "R-RNO-202733", "R-MMU-202733", "R-MMU-159763", "R-HSA-9672391", "R-RNO-416476", "R-HSA-9918481", "R-RNO-159740", "R-HSA-381426", "R-HSA-159763", "R-MMU-977606", "R-HSA-456926", "R-RNO-159763", "R-MMU-140837", "R-HSA-140875", "R-MMU-140875", "R-RNO-381426", "R-HSA-159740", "R-RNO-456926", "R-RNO-375276", "R-MMU-159782", "R-HSA-202733"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR018993": {"description": "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain", "go_ids": ["GO:0005815", "GO:0034453"], "go_terms": ["GO:0005815:microtubule organizing center:C", "GO:0034453:microtubule anchoring:P"], "name": "FOP_dimerisation-dom_N", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-HSA-380284", "R-HSA-5655302", "R-MMU-380270", "R-HSA-380270", "R-RNO-5620912", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380259", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270", "R-HSA-1839117"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR018994": {"description": "Protein of unknown function DUF2002", "go_ids": [], "go_terms": [], "name": "DUF2002", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR018995": {"description": "RNA synthesis protein NSP10, coronavirus", "go_ids": ["GO:0003723", "GO:0008270", "GO:0019079"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0008270:zinc ion binding:F", "GO:0019079:viral genome replication:P"], "name": "RNA_synth_NSP10_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR018996": {"description": "Man1/Src1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Man1/Src1-like_C", "pathway_ids": ["R-HSA-9013405", "R-HSA-9696270", "R-HSA-2995383", "R-HSA-9668328", "R-HSA-9696264", "R-HSA-9013404", "R-HSA-9013423", "R-HSA-9013149", "R-SPO-9668328", "R-HSA-4419969", "R-HSA-2980766", "R-SCE-9668328", "R-HSA-9013408", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-SCE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR018997": {"description": "PUB domain", "go_ids": [], "go_terms": [], "name": "PUB_domain", "pathway_ids": ["R-HSA-532668", "R-MMU-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-RNO-532668", "R-MMU-5357905", "R-HSA-5357786", "R-MMU-532668", "R-MMU-5357956", "R-DME-532668", "R-DRE-532668"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "type": "Domain"}, "IPR018998": {"description": "EndoU ribonuclease, C-terminal", "go_ids": ["GO:0004521"], "go_terms": ["GO:0004521:RNA endonuclease activity:F"], "name": "EndoU_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR018999": {"description": "RNA helicase UPF1, Cys/His rich zinc-binding domain", "go_ids": ["GO:0003724", "GO:0000184", "GO:0005524", "GO:0005737", "GO:0008270", "GO:0003723"], "go_terms": ["GO:0003724:RNA helicase activity:F", "GO:0000184:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay:P", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0008270:zinc ion binding:F", "GO:0003723:RNA binding:F"], "name": "UPF1_CH/ZBD", "pathway_ids": ["R-HSA-975956", "R-DDI-975956", "R-SPO-975956", "R-CEL-975956", "R-DRE-975956", "R-HSA-975957", "R-SCE-975957", "R-DME-975956", "R-CEL-975957", "R-SCE-975956", "R-MMU-975957", "R-DDI-975957", "R-DRE-975957", "R-SPO-975957", "R-DME-975957", "R-MMU-975956"], "pathways": ["R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "type": "Domain"}, "IPR019002": {"description": "Ribosome biogenesis protein Nop16", "go_ids": [], "go_terms": [], "name": "Ribosome_biogenesis_Nop16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019003": {"description": "APC membrane recruitment protein", "go_ids": [], "go_terms": [], "name": "AMER", "pathway_ids": ["R-HSA-5358752", "R-HSA-5358751", "R-HSA-5358749", "R-MMU-196299", "R-HSA-5358747", "R-DRE-195253", "R-HSA-5339716", "R-HSA-5467337", "R-HSA-8951664", "R-HSA-4641262", "R-HSA-5467340", "R-HSA-5467348", "R-MMU-4641262", "R-HSA-9755511", "R-MMU-195253", "R-HSA-196299", "R-DRE-196299", "R-HSA-195253"], "pathways": ["R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-HSA-8951664:r:Neddylation", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Family"}, "IPR019004": {"description": "Uncharacterised protein YqeY/Aim41", "go_ids": [], "go_terms": [], "name": "YqeY/Aim41", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019005": {"description": "Vacuolar R-SNARE Nyv1, longin domain", "go_ids": [], "go_terms": [], "name": "Vacuolar_R-SNAR_Nyv1_longi_dom", "pathway_ids": ["R-SCE-199992"], "pathways": ["R-SCE-199992:r:trans-Golgi Network Vesicle Budding"], "type": "Domain"}, "IPR019006": {"description": "Sterol regulatory element-binding protein 1, C-terminal", "go_ids": ["GO:0045944", "GO:0032933"], "go_terms": ["GO:0045944:positive regulation of transcription by RNA polymerase II:P", "GO:0032933:SREBP signaling pathway:P"], "name": "Sre1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019007": {"description": "Wbp11/ELF5/Saf1, N-terminal domain", "go_ids": ["GO:0006396"], "go_terms": ["GO:0006396:RNA processing:P"], "name": "Wbp11/ELF5/Saf1_N", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-CEL-72163", "R-HSA-9918481", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR019008": {"description": "ER membrane protein complex subunit 7, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Beta_sandwich_EMC7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019009": {"description": "Signal recognition particle receptor, beta subunit", "go_ids": [], "go_terms": [], "name": "SRP_receptor_beta_su", "pathway_ids": ["R-HSA-1799339", "R-HSA-381038"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-381038:r:XBP1(S) activates chaperone genes"], "type": "Family"}, "IPR019010": {"description": "Eukaryotic translation initiation factor 3 subunit E, N-terminal", "go_ids": [], "go_terms": [], "name": "eIF3e_N", "pathway_ids": ["R-CEL-72689", "R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-CEL-72695", "R-HSA-156827", "R-RNO-72689", "R-XTR-72702", "R-MMU-72649", "R-HSA-72695", "R-BTA-72689", "R-RNO-72695", "R-MMU-72706", "R-SPO-72689", "R-BTA-72695", "R-MMU-72695", "R-XTR-72695", "R-DRE-156827", "R-DME-72695", "R-MMU-72702", "R-BTA-156827", "R-RNO-156827", "R-DRE-72695", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-XTR-156827", "R-DME-72689", "R-BTA-72702", "R-HSA-72706", "R-RNO-72702", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-CEL-156827", "R-RNO-72649", "R-DRE-72649", "R-DRE-72702", "R-DRE-72689", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-BTA-72649", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": ["R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Domain"}, "IPR019011": {"description": "Cryptic/Cripto, CFC domain", "go_ids": [], "go_terms": [], "name": "Cryptic/Cripto_CFC-dom", "pathway_ids": ["R-HSA-1181150", "R-HSA-2892247", "R-HSA-1433617"], "pathways": ["R-HSA-1181150:r:Signaling by NODAL", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-HSA-1433617:r:Regulation of signaling by NODAL"], "type": "Domain"}, "IPR019012": {"description": "RNA cap guanine-N2 methyltransferase", "go_ids": ["GO:0036261", "GO:0001510", "GO:0008168"], "go_terms": ["GO:0036261:7-methylguanosine cap hypermethylation:P", "GO:0001510:RNA methylation:P", "GO:0008168:methyltransferase activity:F"], "name": "RNA_cap_Gua-N2-MeTrfase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-1989781", "R-RNO-400206", "R-HSA-2151201", "R-HSA-191859", "R-HSA-381340", "R-RNO-9707564", "R-HSA-9707616", "R-HSA-9931509", "R-HSA-1368108", "R-RNO-191859", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-400206", "R-MMU-191859", "R-MMU-400206", "R-MMU-9707564", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-191859:r:snRNP Assembly", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707616:r:Heme signaling", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-191859:r:snRNP Assembly", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-191859:r:snRNP Assembly", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Family"}, "IPR019013": {"description": "Vacuolar ATPase assembly integral membrane protein Vma21", "go_ids": ["GO:0070072"], "go_terms": ["GO:0070072:vacuolar proton-transporting V-type ATPase complex assembly:P"], "name": "Vma21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019014": {"description": "Multivesicular body sorting factor 12", "go_ids": ["GO:0032509", "GO:0043130", "GO:0000813"], "go_terms": ["GO:0032509:endosome transport via multivesicular body sorting pathway:P", "GO:0043130:ubiquitin binding:F", "GO:0000813:ESCRT I complex:C"], "name": "Mvb12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019015": {"description": "HIRA B motif", "go_ids": [], "go_terms": [], "name": "HIRA_B_motif", "pathway_ids": ["R-SCE-2559584", "R-CEL-2559584"], "pathways": ["R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Conserved_site"}, "IPR019016": {"description": "CRISPR system endoribonuclease Csx1-like, HEPN domain", "go_ids": [], "go_terms": [], "name": "Csx1-like_HEPN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019017": {"description": "Signal transduction histidine kinase RcsC, alpha-beta loop, C-terminal", "go_ids": ["GO:0000160", "GO:0004673", "GO:0005524", "GO:0005886", "GO:0006355", "GO:0016020", "GO:0018106"], "go_terms": ["GO:0000160:phosphorelay signal transduction system:P", "GO:0004673:protein histidine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0005886:plasma membrane:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016020:membrane:C", "GO:0018106:peptidyl-histidine phosphorylation:P"], "name": "Sig_transdc_His_kin_a/b-loop_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019018": {"description": "Rab-binding domain FIP-RBD", "go_ids": [], "go_terms": [], "name": "Rab-bd_FIP-RBD", "pathway_ids": ["R-HSA-5620916", "R-HSA-432040", "R-DRE-5620916", "R-MMU-5620916", "R-MMU-432040"], "pathways": ["R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins"], "type": "Domain"}, "IPR019019": {"description": "H-type lectin domain", "go_ids": ["GO:0030246", "GO:0007155"], "go_terms": ["GO:0030246:carbohydrate binding:F", "GO:0007155:cell adhesion:P"], "name": "H-type_lectin_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019020": {"description": "Cytochrome c-552/DMSO reductase-like, haem-binding domain", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "Cyt-c552/DMSO_Rdtase_haem-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019021": {"description": "E3 ubiquitin-protein ligase substrate receptor Mms22", "go_ids": ["GO:0006281", "GO:0031297", "GO:0006974", "GO:0005634"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0031297:replication fork processing:P", "GO:0006974:DNA damage response:P", "GO:0005634:nucleus:C"], "name": "Mms22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019023": {"description": "Lamin-B receptor of TUDOR domain", "go_ids": [], "go_terms": [], "name": "Lamin-B_rcpt_of_tudor", "pathway_ids": ["PWY-8191", "PWY-2541", "PWY-8238", "PWY-7154", "PWY-8239", "PWY-6074", "PWY-8026", "R-HSA-9013405", "R-RNO-2995383", "R-HSA-9022692", "R-RNO-9022692", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-2995383", "R-RNO-9013148", "R-HSA-9013106", "R-MMU-9013148", "R-MMU-9013404", "R-RNO-9013423", "R-HSA-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-6807047", "R-MMU-9013423", "R-HSA-8980692", "R-MMU-6807047", "R-MMU-9022692", "R-HSA-9013148", "R-RNO-9013404", "R-RNO-9013106", "R-RNO-9013408", "R-HSA-9013408", "R-MMU-9013149", "R-RNO-6807047", "R-MMU-2995383"], "pathways": ["PWY-8191:t:cholesterol biosynthesis (algae, late side-chain reductase)", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7154:t:ergosterol biosynthesis II", "PWY-8239:t:cholesterol biosynthesis (diatoms)", "PWY-6074:t:zymosterol biosynthesis", "PWY-8026:t:sterol biosynthesis (methylotrophs)", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-RNO-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation"], "type": "Domain"}, "IPR019024": {"description": "Ribonuclease H2 subunit B, wHTH domain", "go_ids": [], "go_terms": [], "name": "RNase_H2_suB_wHTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019025": {"description": "Cordon-bleu, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "Cordon-bleu_ubiquitin_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019026": {"description": "Peptidase M64, IgA", "go_ids": [], "go_terms": [], "name": "Peptidase_M64_IgA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019027": {"description": "Pilus biogenesis CpaD-related", "go_ids": [], "go_terms": [], "name": "Pilus_biogenesis_CpaD-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019028": {"description": "Carbohydrate binding domain CBM49", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "CBM_49", "pathway_ids": ["PWY-6788"], "pathways": ["PWY-6788:t:cellulose degradation II (fungi)"], "type": "Domain"}, "IPR019029": {"description": "Type III secretion system, PrgH/EprH-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "T3SS_PrgH/EprH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019034": {"description": "Uncharacterised protein family UPF0390", "go_ids": [], "go_terms": [], "name": "UPF0390", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019035": {"description": "Mediator complex, subunit Med12", "go_ids": ["GO:0003712", "GO:0006357", "GO:0016592"], "go_terms": ["GO:0003712:transcription coregulator activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C"], "name": "Mediator_Med12", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR019036": {"description": "Restriction endonuclease, type II, ApaLI", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_ApaLI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019037": {"description": "Restriction endonuclease, type II, Bsp6I", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_Bsp6I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019038": {"description": "DNA polymerase delta subunit 3", "go_ids": ["GO:0005634", "GO:0006260", "GO:0043625"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006260:DNA replication:P", "GO:0043625:delta DNA polymerase complex:C"], "name": "POLD3", "pathway_ids": ["R-BTA-5358606", "R-BTA-174411", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-174414", "R-SPO-5656169", "R-HSA-5696397", "R-HSA-5358606", "R-MMU-174417", "R-BTA-174437", "R-BTA-174417", "R-MMU-110314", "R-HSA-174417", "R-MMU-174414", "R-SPO-69091", "R-BTA-5651801", "R-BTA-69166", "R-MMU-174437", "R-BTA-5696397", "R-HSA-6782210", "R-BTA-5656169", "R-BTA-110314", "R-BTA-5696400", "R-HSA-5656169", "R-BTA-69183", "R-MMU-5358606", "R-SPO-69166", "R-MMU-5696400", "R-MMU-5358565", "R-SPO-5696397", "R-MMU-5651801", "R-BTA-6782135", "R-SPO-69183", "R-BTA-69091", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-174411", "R-HSA-5651801", "R-HSA-69166", "R-MMU-69183", "R-SPO-5696400", "R-BTA-5358565", "R-SPO-110314", "R-SPO-6782210", "R-HSA-69183", "R-BTA-5685942", "R-MMU-69166", "R-HSA-5696400", "R-BTA-6782210", "R-HSA-5358565", "R-BTA-174414", "R-SPO-6782135", "R-HSA-69091", "R-HSA-174437", "R-MMU-6782210", "R-MMU-5696397", "R-MMU-174411", "R-MMU-69091", "R-GGA-353416", "R-HSA-110314", "R-SPO-5651801"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-69091:r:Polymerase switching", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-69183:r:Processive synthesis on the lagging strand", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-6782135:r:Dual incision in TC-NER", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-BTA-69091:r:Polymerase switching", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-BTA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-69091:r:Polymerase switching", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-GGA-353416:r:Resolution of Abasic Sites (AP sites)", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR019039": {"description": "T4 RNA ligase 1-like, N-terminal", "go_ids": [], "go_terms": [], "name": "T4-Rnl1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019041": {"description": "SSXRD motif", "go_ids": ["GO:0005634", "GO:0006355"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "SSXRD_motif", "pathway_ids": ["R-RNO-212436", "R-HSA-212436", "R-MMU-3214841", "R-HSA-3214841", "R-MMU-212436", "R-RNO-3214841", "R-HSA-912446"], "pathways": ["R-RNO-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-212436:r:Generic Transcription Pathway", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-HSA-912446:r:Meiotic recombination"], "type": "Conserved_site"}, "IPR019042": {"description": "Restriction endonuclease, type II, CfrBI", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_CfrBI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019043": {"description": "Restriction endonuclease, type II, HindIII", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_HindIII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019044": {"description": "Restriction endonuclease, type II, HindVP", "go_ids": ["GO:0003677", "GO:0009036", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_II_HindVP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019045": {"description": "Restriction endonuclease, type II, HinfI-like", "go_ids": ["GO:0003677", "GO:0009036", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_II_HinfI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019046": {"description": "Restriction endonuclease, type II, NgoPII", "go_ids": ["GO:0003677", 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"R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-DME-3371453", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-DME-159227", "R-HSA-168325", "R-MMU-170822", "R-HSA-9609690", "R-DRE-3371453", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-9615933", "R-MMU-159227", "R-RNO-4085377", "R-HSA-9615933", "R-SPO-4570464", "R-DRE-159227", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-9705671", "R-SPO-159227", "R-HSA-3108214", "R-HSA-191859", "R-SPO-159231", "R-DRE-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-HSA-1169408", "R-DRE-191859", "R-MMU-4615885", "R-HSA-159227", "R-DRE-3108214", "R-DRE-159236", "R-MMU-4085377", "R-HSA-168333", "R-HSA-165054", "R-CEL-3108214", "R-RNO-159236", "R-HSA-4615885", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-168276", "R-HSA-168271", 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activity:F"], "name": "Mediator_Med18", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR019096": {"description": "YopX protein", "go_ids": [], "go_terms": [], "name": "YopX_protein", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019097": {"description": "Mg296 protein", "go_ids": [], "go_terms": [], "name": "Mg296_protein", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019098": {"description": "Histone chaperone domain CHZ", "go_ids": [], "go_terms": [], "name": "Histone_chaperone_domain_CHZ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019099": {"description": "Uncharacterised protein family PGPGW, transmembrane", "go_ids": [], "go_terms": [], "name": "Uncharacterised_PGPGW_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019102": {"description": "HMG box transcription factor BBX, domain of unknown function DUF2028", "go_ids": [], "go_terms": [], "name": "TF_HMG_box_BBX_DUF2028", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019103": {"description": "Aspartic peptidase, DDI1-type", "go_ids": ["GO:0004190", "GO:0006508"], "go_terms": ["GO:0004190:aspartic-type endopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Peptidase_aspartic_DDI1-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019106": {"description": "Type-F conjugative transfer system pilin assembly protein TrbC", "go_ids": [], "go_terms": [], "name": "T4SS_TrbC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019108": {"description": "Cytochrome c oxidase caa3-type, assembly factor CtaG-related", "go_ids": [], "go_terms": [], "name": "Caa3_assmbl_CtaG-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019109": {"description": "Magnetosome protein MamF/MmsF", "go_ids": [], "go_terms": [], "name": "MamF_MmsF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019110": {"description": "Uncharacterised protein family, RAQPRD", "go_ids": [], "go_terms": [], "name": "Uncharacterised_RAQPRD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019111": {"description": "Plasmodium RESA, N-terminal", "go_ids": [], "go_terms": [], "name": "PRESA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019114": {"description": "Chaperone lipoprotein, PulS/OutS-like", "go_ids": [], "go_terms": [], "name": "Chap_lipoprot_PulS/OutS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019117": {"description": "CRISPR-associated protein, Cmr3", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_protein_Cmr3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019121": {"description": "CRISPR-associated protein, CXXC-CXXC domain", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_CXXC-CXXC_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019127": {"description": "Exosortase", "go_ids": [], "go_terms": [], "name": "Exosortase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019128": {"description": "Sister chromatid cohesion protein Dcc1", "go_ids": ["GO:0007064", "GO:0031390"], "go_terms": ["GO:0007064:mitotic sister chromatid cohesion:P", "GO:0031390:Ctf18 RFC-like complex:C"], "name": "Dcc1", "pathway_ids": ["R-HSA-174411", "R-MMU-174411", "R-DRE-174411"], "pathways": ["R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-DRE-174411:r:Polymerase switching on the C-strand of the telomere"], "type": "Family"}, "IPR019129": {"description": "Folate-sensitive fragile site protein Fra10Ac1", "go_ids": [], "go_terms": [], "name": "Folate-sensitive_fs_Fra10Ac1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019130": {"description": "Macoilin", "go_ids": ["GO:0030867", "GO:0023041"], "go_terms": ["GO:0030867:rough endoplasmic reticulum membrane:C", "GO:0023041:neuronal signal transduction:P"], "name": "Macoilin", "pathway_ids": ["R-HSA-8980692", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-DRE-8980692", "R-SSC-9013106", "R-RNO-9013106", "R-SSC-8980692", "R-HSA-9013106"], "pathways": ["R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-SSC-9013106:r:RHOC GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-SSC-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle"], "type": "Family"}, "IPR019131": {"description": "Cortactin-binding protein-2, N-terminal", "go_ids": [], "go_terms": [], "name": "Cortactin-binding_p2_N", "pathway_ids": ["R-HSA-9013405"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle"], "type": "Domain"}, "IPR019133": {"description": "MICOS complex subunit MIC60", "go_ids": [], "go_terms": [], "name": "MIC60", "pathway_ids": ["R-HSA-8949613"], "pathways": ["R-HSA-8949613:r:Cristae formation"], "type": "Family"}, "IPR019134": {"description": "Splicing factor Cactin, C-terminal", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Cactin_C", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-DME-72163", "R-CEL-72163", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR019135": {"description": "Polycomb protein, VEFS-Box", "go_ids": [], "go_terms": [], "name": "Polycomb_protein_VEFS-Box", "pathway_ids": ["R-MMU-8953750", "R-DME-9909649", "R-MMU-3214841", "R-HSA-2559580", "R-DRE-2559580", "R-DME-212300", "R-XTR-212300", "R-XTR-9764725", "R-DRE-8953750", "R-HSA-9764725", "R-MMU-212300", "R-HSA-8953750", "R-HSA-9609690", "R-MMU-9764725", "R-MMU-2559580", "R-MMU-8943724", "R-XTR-8953750", "R-HSA-9710421", "R-DME-2559580", "R-HSA-212300", "R-MMU-4551638", "R-HSA-9909649", "R-XTR-9909649", "R-DRE-3214841", "R-HSA-3214841", "R-MMU-9909649", "R-HSA-8943724", "R-DME-9764725", "R-XTR-2559580", "R-DME-8953750", "R-DME-8943724", "R-DRE-212300", "R-HSA-4551638", "R-DRE-9909649", "R-HSA-5617472", "R-DRE-9764725"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9710421:r:Defective pyroptosis", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription"], "type": "Domain"}, "IPR019136": {"description": "Transcription factor IIIC subunit 5, HTH domain", "go_ids": [], "go_terms": [], "name": "TF_IIIC_su-5_HTH", "pathway_ids": ["R-SCE-76066", "R-DDI-76066", "R-DDI-76061", "R-SPO-76066", "R-HSA-76066", "R-MMU-76061", "R-HSA-76061", "R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR019137": {"description": "Nck-associated protein 1", "go_ids": [], "go_terms": [], "name": "Nck-associated_protein-1", "pathway_ids": ["R-HSA-5663213", "R-HSA-6798695", "R-CEL-6798695", "R-DRE-2029482", "R-RNO-9013149", "R-DRE-9013404", "R-MMU-4420097", "R-MMU-9013404", "R-DDI-9013149", "R-CEL-9013149", "R-RNO-2029482", "R-HSA-4420097", "R-HSA-9013423", "R-RNO-5663213", "R-DME-2029482", "R-MMU-5663213", "R-DRE-9013149", "R-RNO-9013404", "R-DDI-9013423", "R-CEL-9013423", "R-DME-5663213", "R-DDI-2029482", "R-DDI-6798695", "R-DRE-5663213", "R-DME-9013149", "R-DME-6798695", "R-DDI-5663213", "R-HSA-2029482", "R-CEL-5663213", "R-MMU-2029482", "R-CEL-2029482", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-9013423", "R-HSA-9013149", "R-MMU-9013149", "R-MMU-6798695", "R-DDI-9013404", "R-HSA-9664422", "R-DME-4420097", "R-DME-9013423", "R-RNO-4420097", "R-DRE-9013423"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-DRE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DRE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR019138": {"description": "De-etiolated protein 1, Det1", "go_ids": [], "go_terms": [], "name": "De-etiolated_protein_1_Det1", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR019139": {"description": "Leucine-rich repeat flightless-interacting protein 1/2", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "LRRFIP1/2", "pathway_ids": ["R-HSA-5655302", "R-HSA-3134973", "R-HSA-1839117"], "pathways": ["R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Family"}, "IPR019140": {"description": "Mini-chromosome maintenance complex-binding protein", "go_ids": [], "go_terms": [], "name": "MCM_complex-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019141": {"description": "Protein PHLOEM PROTEIN 2-LIKE A10-related", "go_ids": [], "go_terms": [], "name": "PP2-like-A10-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019142": {"description": "Dymeclin", "go_ids": [], "go_terms": [], "name": "Dymeclin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019144": {"description": "Membralin", "go_ids": [], "go_terms": [], "name": "Membralin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019145": {"description": "Mediator complex, subunit Med10", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med10", "pathway_ids": ["R-HSA-1989781", "R-BTA-9841922", "R-DME-9841922", "R-HSA-381340", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Family"}, "IPR019147": {"description": "Suppressor of white apricot, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SWAP_N_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019148": {"description": "Nuclear protein DGCR14/ESS-2", "go_ids": [], "go_terms": [], "name": "Nuclear_protein_DGCR14_ESS-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019149": {"description": "Alpha/beta hydrolase domain-containing protein 18", "go_ids": [], "go_terms": [], "name": "ABHD18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019150": {"description": "Vesicle transport protein, Use1", "go_ids": [], "go_terms": [], "name": "Vesicle_transport_protein_Use1", "pathway_ids": ["R-DME-6811434", "R-HSA-6811434", "R-SCE-6811434", "R-DRE-6811434", "R-CEL-6811434", "R-SPO-6811434", "R-MMU-6811434"], "pathways": ["R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR019151": {"description": "Proteasome assembly chaperone 2", "go_ids": [], "go_terms": [], "name": "Proteasome_assmbl_chaperone_2", "pathway_ids": ["R-SCE-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-DRE-9907900", "R-BTA-9907900", "R-DDI-9907900"], "pathways": ["R-SCE-9907900:r:Proteasome assembly", "R-HSA-9907900:r:Proteasome assembly", "R-MMU-9907900:r:Proteasome assembly", "R-DRE-9907900:r:Proteasome assembly", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-9907900:r:Proteasome assembly"], "type": "Family"}, "IPR019152": {"description": "Protein of unknown function DUF2046", "go_ids": [], "go_terms": [], "name": "DUF2046", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019153": {"description": "DDRGK domain containing protein", "go_ids": [], "go_terms": [], "name": "DDRGK_dom-contain", "pathway_ids": ["R-DRE-8980692", "R-HSA-8980692", "R-MMU-8980692"], "pathways": ["R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Family"}, "IPR019154": {"description": "Arb2-like domain", "go_ids": [], "go_terms": [], "name": "Arb2-like_domain", "pathway_ids": ["R-SPO-3371511", "R-SCE-3371511", "R-SPO-4551638"], "pathways": ["R-SPO-3371511:r:HSF1 activation", "R-SCE-3371511:r:HSF1 activation", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins"], "type": "Domain"}, "IPR019155": {"description": "CLEC16A/TT9, N-terminal", "go_ids": [], "go_terms": [], "name": "CLEC16A/TT9_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019156": {"description": "Ataxin-10 domain", "go_ids": [], "go_terms": [], "name": "Ataxin-10_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019159": {"description": "CCDC93, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CCDC93_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019160": {"description": "Exocyst complex component Sec3, coiled-coil", "go_ids": ["GO:0000145", "GO:0006887"], "go_terms": ["GO:0000145:exocyst:C", "GO:0006887:exocytosis:P"], "name": "Sec3_CC", "pathway_ids": ["R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-HSA-9920588", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Domain"}, "IPR019162": {"description": "Fanconi anemia complex, subunit FancL, WD-repeat containing domain", "go_ids": [], "go_terms": [], "name": "FancL_WD-rpt_cont_dom", "pathway_ids": ["PWY-7511", "R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR019163": {"description": "THO complex, subunit 5", "go_ids": [], "go_terms": [], "name": "THO_Thoc5", "pathway_ids": ["R-RNO-73856", "R-DRE-159236", "R-DRE-73856", "R-MMU-72187", "R-HSA-73856", "R-RNO-159236", "R-HSA-159236", "R-MMU-73856", "R-HSA-72187", "R-DME-159236", "R-DME-73856", "R-HSA-9680350", "R-MMU-159236"], "pathways": ["R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR019164": {"description": "Transmembrane protein 147", "go_ids": [], "go_terms": [], "name": "TMEM147", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019165": {"description": "Peptidase M76, ATP23", "go_ids": ["GO:0004222"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F"], "name": "Peptidase_M76_ATP23", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR019166": {"description": "MICOS complex subunit MIC26/MIC27", "go_ids": ["GO:0042407", "GO:0061617"], "go_terms": ["GO:0042407:cristae formation:P", "GO:0061617:MICOS complex:C"], "name": "MIC26/MIC27", "pathway_ids": ["R-HSA-114608", "R-CEL-114608", "R-BTA-114608", "R-HSA-8949613", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-8949613:r:Cristae formation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR019167": {"description": "mRNA decay factor PAT1 domain", "go_ids": [], "go_terms": [], "name": "PAT1_dom", "pathway_ids": ["R-SPO-430039", "R-SCE-430039", "R-RNO-430039", "R-MMU-430039", "R-DRE-430039", "R-HSA-430039"], "pathways": ["R-SPO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR019168": {"description": "Nuclear envelope phosphatase-regulatory subunit 1", "go_ids": ["GO:0071595"], "go_terms": ["GO:0071595:Nem1-Spo7 phosphatase complex:C"], "name": "NEP1-R1", "pathway_ids": ["R-MMU-4419969", "R-CEL-4419969", "R-HSA-4419969", "R-XTR-4419969", "R-DME-4419969", "R-BTA-4419969", "R-DRE-4419969"], "pathways": ["R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-DRE-4419969:r:Depolymerization of the Nuclear Lamina"], "type": "Family"}, "IPR019169": {"description": "Transmembrane protein 26", "go_ids": [], "go_terms": [], "name": "Transmembrane_26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019170": {"description": "Meckelin", "go_ids": ["GO:0060271", "GO:0036038"], "go_terms": ["GO:0060271:cilium assembly:P", "GO:0036038:MKS complex:C"], "name": "Meckelin", "pathway_ids": ["R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912"], "pathways": ["R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR019171": {"description": "Intermembrane space protein MIX23", "go_ids": ["GO:0005758"], "go_terms": ["GO:0005758:mitochondrial intermembrane space:C"], "name": "MIX23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019172": {"description": "Osteopetrosis-associated transmembrane protein 1 precursor", "go_ids": [], "go_terms": [], "name": "Osteopetrosis-assoc_TM_1", "pathway_ids": ["R-CEL-2672351", "R-HSA-2672351", "R-MMU-2672351"], "pathways": ["R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR019173": {"description": "NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit", "go_ids": [], "go_terms": [], "name": "NADH_UbQ_OxRdtase_B5_su", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR019174": {"description": "NADH dehydrogenase 1, beta subcomplex, subunit 6", "go_ids": ["GO:0006120"], "go_terms": ["GO:0006120:mitochondrial electron transport, NADH to ubiquinone:P"], "name": "NADH_DH_b-subcmplx_su6", "pathway_ids": ["R-HSA-9837999", "R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR019175": {"description": "Prp31 C-terminal", "go_ids": [], "go_terms": [], "name": "Prp31_C", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR019176": {"description": "Cytochrome B561-related", "go_ids": [], "go_terms": [], "name": "Cytochrome_B561-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019177": {"description": "Golgin subfamily A member 5", "go_ids": ["GO:0007030"], "go_terms": ["GO:0007030:Golgi organization:P"], "name": "Golgin_subfamily_A_member_5", "pathway_ids": ["R-HSA-6811438"], "pathways": ["R-HSA-6811438:r:Intra-Golgi traffic"], "type": "Family"}, "IPR019178": {"description": "Phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "go_ids": ["GO:0046856", "GO:0034597"], "go_terms": ["GO:0046856:phosphatidylinositol dephosphorylation:P", "GO:0034597:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity:F"], "name": "PtdIns-P2-Ptase", "pathway_ids": ["PWY-6367", "PWY-6368", "R-MMU-6811555", "R-DRE-8847453", "R-MMU-8847453", "R-DRE-6811555", "R-RNO-6811555", "R-HSA-6811555", "R-HSA-8847453", "R-RNO-8847453"], "pathways": ["PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-6368:t:3-phosphoinositide degradation", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-DRE-8847453:r:Synthesis of PIPs in the nucleus", "R-MMU-8847453:r:Synthesis of PIPs in the nucleus", "R-DRE-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-8847453:r:Synthesis of PIPs in the nucleus", "R-RNO-8847453:r:Synthesis of PIPs in the nucleus"], "type": "Family"}, "IPR019179": {"description": "Coiled-coil domain-containing protein 149", "go_ids": [], "go_terms": [], "name": "CC149", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019180": {"description": "Oxidoreductase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Oxidoreductase-like_N", "pathway_ids": ["R-HSA-1237044", "R-MMU-1237044"], "pathways": ["R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen"], "type": "Domain"}, "IPR019181": {"description": "LSM12, anticodon-binding domain", "go_ids": [], "go_terms": [], "name": "LSM12_ABD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019182": {"description": "Cytochrome b-c1 complex subunit 10, fungi", "go_ids": ["GO:0006122"], "go_terms": ["GO:0006122:mitochondrial 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SYS1-related", "go_ids": [], "go_terms": [], "name": "Integral_membrane_SYS1-rel", "pathway_ids": ["R-DDI-6811440", "R-SCE-6811440", "R-BTA-6811440", "R-HSA-6811440", "R-MMU-6811440"], "pathways": ["R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR019186": {"description": "Nucleolar protein 12", "go_ids": [], "go_terms": [], "name": "Nucleolar_protein_12", "pathway_ids": ["R-HSA-6791226"], "pathways": ["R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR019188": {"description": "snRNA-activating protein complex subunit 1", "go_ids": [], "go_terms": [], "name": "SNAPC1", "pathway_ids": ["R-HSA-76071", "R-MMU-76071", "R-HSA-749476", "R-HSA-6807505", "R-MMU-6807505"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR019189": {"description": "Large ribosomal subunit protein mL41", "go_ids": ["GO:0005762", "GO:0003735"], "go_terms": ["GO:0005762:mitochondrial large ribosomal subunit:C", "GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_mL41", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-CEL-5389840", "R-HSA-9937383", "R-DRE-5389840", "R-CEL-9937383", "R-DRE-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-CEL-5419276", "R-DME-5389840", "R-RNO-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-DME-9937383", "R-RNO-5389840", "R-DRE-5419276"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR019190": {"description": "Exonuclease V", "go_ids": ["GO:0045145"], "go_terms": ["GO:0045145:single-stranded DNA 5'-3' DNA exonuclease activity:F"], "name": "EXOV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019191": {"description": "Essential protein Yae1, N-terminal", "go_ids": [], "go_terms": [], "name": "Essential_protein_Yae1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019192": {"description": "Large ribosomal subunit protein mL40", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL40", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-RNO-5389840"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR019193": {"description": "Ubiquitin-conjugating enzyme E2-binding protein", "go_ids": [], "go_terms": [], "name": "UBQ-conj_enz_E2-bd_prot", "pathway_ids": ["PWY-7511", "R-SPO-983168", "R-BTA-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR019194": {"description": "Transcription elongation factor Eaf, N-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt_elong_fac_Eaf_N", "pathway_ids": ["R-DME-112382", "R-RNO-112382", "R-RNO-674695", "R-DME-674695", "R-HSA-75955", "R-RNO-75955", "R-MMU-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-HSA-112382", "R-MMU-112382"], "pathways": ["R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR019195": {"description": "ABC transporter, ATPase, putative", "go_ids": [], "go_terms": [], "name": "ABC_ATPase_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019196": {"description": "ABC-type uncharacterised transport system", "go_ids": [], "go_terms": [], "name": "ABC_transp_unknown", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019197": {"description": "Biotin-protein ligase, N-terminal", "go_ids": [], "go_terms": [], "name": "Biotin-prot_ligase_N", "pathway_ids": ["R-SPO-196780", "R-SCE-196780"], "pathways": ["R-SPO-196780:r:Biotin transport and metabolism", "R-SCE-196780:r:Biotin transport and metabolism"], "type": "Domain"}, "IPR019198": {"description": "Beta-propeller domain-containing family", "go_ids": [], "go_terms": [], "name": "Beta_propeller_containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019199": {"description": "Virulence-associated protein D / CRISPR associated protein Cas2", "go_ids": [], "go_terms": [], "name": "Virulence_VapD/CRISPR_Cas2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019200": {"description": "ATP adenylyltransferase, C-terminal", "go_ids": ["GO:0003877"], "go_terms": ["GO:0003877:ATP:ADP adenylyltransferase activity:F"], "name": "ATP_adenylylTrfase_C", "pathway_ids": ["PWY-5279"], "pathways": ["PWY-5279:t:sulfite oxidation II"], "type": "Domain"}, "IPR019201": {"description": "Protein of unknown function DUF2065", "go_ids": [], "go_terms": [], "name": "DUF2065", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019202": {"description": "Protein of unknown function DUF2067", "go_ids": [], "go_terms": [], "name": "DUF2067", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019204": {"description": "Domain of unknown function DUF2070, membrane", "go_ids": [], "go_terms": [], "name": "DUF2070_membrane", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019205": {"description": "Protein of unknown function DUF2080, transposon-encoded", "go_ids": [], "go_terms": [], "name": "DUF2080_transposon-encoded", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019206": {"description": "Protein of unknown function DUF2085, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF2085_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019207": {"description": "Protein of unknown function DUF2092, periplasmic", "go_ids": [], "go_terms": [], "name": "DUF2092", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019208": {"description": "Protein of unknown function DUF2097", "go_ids": [], "go_terms": [], "name": "DUF2097", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019209": {"description": "Protein of unknown function DUF2098", "go_ids": [], "go_terms": [], "name": "DUF2098", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019211": {"description": "Energy-converting hydrogenase subunit EhaL", "go_ids": [], "go_terms": [], "name": "EhaL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019212": {"description": "EhaG-like", "go_ids": [], "go_terms": [], "name": "EhaG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019213": {"description": "EhaD-like", "go_ids": [], "go_terms": [], "name": "EhaD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019214": {"description": "EhaC-like", "go_ids": [], "go_terms": [], "name": "EhaC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019215": {"description": "Protein of unknown function DUF2115", "go_ids": [], "go_terms": [], "name": "DUF2115", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019216": {"description": "Protein of unknown function DUF2116, treble clef zinc finger", "go_ids": [], "go_terms": [], "name": "DUF2116_treble_clef", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019217": {"description": "Protein of unknown function DUF2118", "go_ids": [], "go_terms": [], "name": "DUF2118", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019218": {"description": "Protein of unknown function DUF2119", "go_ids": [], "go_terms": [], "name": "DUF2119", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019219": {"description": "Protein of unknown function DUF2130", "go_ids": [], "go_terms": [], "name": "DUF2130", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019220": {"description": "Uncharacterized protein YfaP, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YfaP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019223": {"description": "Domain of unknown function DUF2147", "go_ids": [], "go_terms": [], "name": "DUF2147", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019224": {"description": "Domain of unknown function DUF2148", "go_ids": [], "go_terms": [], "name": "DUF2148", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019225": {"description": "Protein of unknown function DUF2155", "go_ids": [], "go_terms": [], "name": "DUF2155", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019226": {"description": "Protein of unknown function DUF2158", "go_ids": [], "go_terms": [], "name": "DUF2158", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019230": {"description": "tRNA (guanine-N(1)-)-methyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "RNA_MeTrfase_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019231": {"description": "Protein of unknown function DUF2170", "go_ids": [], "go_terms": [], "name": "DUF2170", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019235": {"description": "Protein of unknown function DUF2178, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF2178_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019236": {"description": "Phosphatidate phosphatase APP1, catalytic domain", "go_ids": ["GO:0008195"], "go_terms": ["GO:0008195:phosphatidate phosphatase activity:F"], "name": "APP1_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019238": {"description": "Transcriptional regulator, AbiEi 2 antitoxin, Type IV TA system", "go_ids": [], "go_terms": [], "name": "AbiEi_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019239": {"description": "Bacterial antitoxin of type II TA system, VapB", "go_ids": [], "go_terms": [], "name": "VapB_antitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019240": {"description": "Protein of unknown function DUF2196", "go_ids": [], "go_terms": [], "name": "DUF2196", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019241": {"description": "Protein of unknown function DUF2197", "go_ids": [], "go_terms": [], "name": "DUF2197", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019242": {"description": "Protein of unknown function DUF2198", "go_ids": [], "go_terms": [], "name": "DUF2198", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019243": {"description": "Domain of unknown function DUF2202", "go_ids": [], "go_terms": [], "name": "DUF2202", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019247": {"description": "Histidine kinase BarA, N-terminal", "go_ids": [], "go_terms": [], "name": "Histidine_kinase_BarA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019248": {"description": "Glucodextranase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Glucodextran_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019249": {"description": "Domain of unknown function DUF2226", "go_ids": [], "go_terms": [], "name": "DUF2226", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019250": {"description": "Protein of unknown function DUF2227, metal-binding", "go_ids": [], "go_terms": [], "name": "DUF2227_metal-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019251": {"description": "Domain of unknown function DUF2231, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF2231_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019253": {"description": "Protein of unknown function DUF2244, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF2244_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019254": {"description": "Protein of unknown function DUF2250", "go_ids": [], "go_terms": [], "name": "DUF2250", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019257": {"description": "Histidine-specific methyltransferase, SAM-dependent methyltransferase domain", "go_ids": [], "go_terms": [], "name": "MTase_SAM-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019258": {"description": "Mediator complex, subunit Med4", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med4", "pathway_ids": ["R-HSA-1989781", "R-BTA-9841922", "R-DME-9841922", "R-HSA-381340", "R-RNO-9841922", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Family"}, "IPR019260": {"description": "Domain of unknown function DUF2262", "go_ids": [], "go_terms": [], "name": "DUF2262", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019261": {"description": "Microbial-type PARG, catalytic domain", "go_ids": [], "go_terms": [], "name": "PARG_cat_microbial", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019262": {"description": "Domain of unknown function DUF2272", "go_ids": [], "go_terms": [], "name": "DUF2272", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019264": {"description": "Domain of unknown function DUF2179", "go_ids": [], "go_terms": [], "name": "DUF2179", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019265": {"description": "RNA transcription, translation and transport factor protein", "go_ids": [], "go_terms": [], "name": "RTRAF", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR019266": {"description": "Small ribosomal subunit protein mS27", "go_ids": [], "go_terms": [], "name": "Ribosomal_mS27", "pathway_ids": ["R-MMU-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Family"}, "IPR019267": {"description": "CRISPR-associated protein Cas6, C-terminal", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Cas6_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019268": {"description": "Protein of unknown function DUF2278", "go_ids": [], "go_terms": [], "name": "DUF2278", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019269": {"description": "Biogenesis of lysosome-related organelles complex-1, subunit 2", "go_ids": [], "go_terms": [], "name": "BLOC1_su2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019270": {"description": "Putative hypoxanthine phosphoribosyltransferase", "go_ids": [], "go_terms": [], "name": "MM_0201", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019271": {"description": "Protein of unknown function DUF2284, metal-binding", "go_ids": [], "go_terms": [], "name": "DUF2284_metal-binding", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019273": {"description": "Lunapark zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Lunapark_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019275": {"description": "Protein of unknown function DUF2301", "go_ids": [], "go_terms": [], "name": "DUF2301", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019276": {"description": "Protein of unkown function DUF2303", "go_ids": [], "go_terms": [], "name": "DUF2303", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019277": {"description": "Protein of unknown function DUF2304", "go_ids": [], "go_terms": [], "name": "DUF2304", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019278": {"description": "DICT domain", "go_ids": [], "go_terms": [], "name": "DICT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019282": {"description": "Glycoamylase-like, conserved domain", "go_ids": [], "go_terms": [], "name": "Glycoamylase-like_cons_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019283": {"description": "Protein of unknown function DUF2330", "go_ids": [], "go_terms": [], "name": "DUF2330", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019284": {"description": "Uncharacterized protein RP532", "go_ids": [], "go_terms": [], "name": "RP532", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019285": {"description": "SpbR-like", "go_ids": [], "go_terms": [], "name": "SpbR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019286": {"description": "Protein of unknown function DUF2339, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF2339_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019287": {"description": "Holliday junction resolvase-related domain", "go_ids": [], "go_terms": [], "name": "Hday_junct_resolvase-rel_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019288": {"description": "Predicted 3'-5' exonuclease, PolB-like", "go_ids": [], "go_terms": [], "name": "3'-5'_exonuclease_PolB-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019289": {"description": "Tail assembly protein E/E'", "go_ids": [], "go_terms": [], "name": "Phage_tail_E/E'", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019290": {"description": "Glycosyltransferase 2-like, prokaryotic type", "go_ids": [], "go_terms": [], "name": "GlycosylTrfase-like_prok", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019291": {"description": "Host attachment protein", "go_ids": [], "go_terms": [], "name": "Host_attachment_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019292": {"description": "Type IV methyl-directed restriction enzyme EcoKMcrBC", "go_ids": [], "go_terms": [], "name": "McrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019293": {"description": "Thiamine-phosphate synthase ThiN-like", "go_ids": [], "go_terms": [], "name": "ThiN-like", "pathway_ids": ["PWY-8457", "PWY-6894", "PWY-6908", "PWY-6907", "PWY-7356", "PWY-6897", "PWY-6893"], "pathways": ["PWY-8457:t:thiamine diphosphate salvage V", "PWY-6894:t:thiamine diphosphate biosynthesis I (E. coli)", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "PWY-6897:t:thiamine diphosphate salvage II", "PWY-6893:t:thiamine diphosphate biosynthesis II (Bacillus)"], "type": "Domain"}, "IPR019294": {"description": "Translational regulator Com", "go_ids": [], "go_terms": [], "name": "Translation_reg_Com", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019296": {"description": "Uncharacterised protein family, nitrogen regulatory protein PII-related", "go_ids": [], "go_terms": [], "name": "Unchr_N-regulatory-PII-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019300": {"description": "CO dehydrogenase accessory protein CooT", "go_ids": [], "go_terms": [], "name": "CooT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019301": {"description": "Flagellar protein FlgJ, N-terminal", "go_ids": [], "go_terms": [], "name": "Flagellar_prot_FlgJ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019302": {"description": "CD-NTase-associated protein 12/Pycsar effector protein, TIR domain", "go_ids": ["GO:0050135"], "go_terms": ["GO:0050135:NADP+ nucleosidase activity:F"], "name": "CAP12/PCTIR_TIR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019303": {"description": "vWA found in TerF C terminus", "go_ids": [], "go_terms": [], "name": "vWA_TerF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019305": {"description": "Uncharacterised protein family Smp", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Smp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019306": {"description": "Transmembrane protein 231", "go_ids": [], "go_terms": [], "name": "TMEM231", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019307": {"description": "RNA-binding protein AU-1/Ribonuclease E/G", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "RNA-bd_AU-1/RNase_E/G", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019308": {"description": "Transmembrane protein 214", "go_ids": [], "go_terms": [], "name": "TMEM214", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019309": {"description": "WASH complex subunit 3", "go_ids": ["GO:0071203"], "go_terms": ["GO:0071203:WASH complex:C"], "name": "WASHC3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019310": {"description": "rRNA-processing protein Efg1", "go_ids": ["GO:0006364"], "go_terms": ["GO:0006364:rRNA processing:P"], "name": "Efg1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019311": {"description": "Ferry endosomal RAB5 effector complex subunit 3", "go_ids": [], "go_terms": [], "name": "Fy-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019312": {"description": "CCR4-NOT transcription complex subunit 11, C-terminal domain", "go_ids": ["GO:0030014"], "go_terms": ["GO:0030014:CCR4-NOT complex:C"], "name": "CNOT11_C", "pathway_ids": ["R-MMU-6804115", "R-DDI-6804115", "R-HSA-6804115", "R-MMU-429947", "R-DRE-6804115", "R-HSA-9820841", "R-HSA-429947", "R-RNO-6804115"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DDI-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-429947:r:Deadenylation of mRNA", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Domain"}, "IPR019313": {"description": "Mediator complex, subunit Med17", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med17", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-BTA-9841922", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR019314": {"description": "BLOC-1-related complex subunit 6", "go_ids": [], "go_terms": [], "name": "BORCS6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019315": {"description": "Multiple myeloma tumor-associated protein 2-like, N-terminal", "go_ids": [], "go_terms": [], "name": "MMTA2_N", "pathway_ids": ["R-MMU-6798695", "R-SPO-6798695", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR019316": {"description": "G8 domain", "go_ids": [], "go_terms": [], "name": "G8_domain", "pathway_ids": ["R-MMU-2160916", "R-DDI-2160916", "R-HSA-2160916"], "pathways": ["R-MMU-2160916:r:Hyaluronan degradation", "R-DDI-2160916:r:Hyaluronan degradation", "R-HSA-2160916:r:Hyaluronan degradation"], "type": "Domain"}, "IPR019317": {"description": "Membrane protein BRI3", "go_ids": [], "go_terms": [], "name": "BRI3", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-BTA-6798695", "R-RNO-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR019318": {"description": "Guanine nucleotide exchange factor, Ric8", "go_ids": [], "go_terms": [], "name": "Gua_nucleotide_exch_fac_Ric8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019319": {"description": "Plasminogen receptor (KT)", "go_ids": ["GO:0010756", "GO:0005886"], "go_terms": ["GO:0010756:positive regulation of plasminogen activation:P", "GO:0005886:plasma membrane:C"], "name": "Plg-R(KT)", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019320": {"description": "BLOC-1-related complex subunit 8", "go_ids": [], "go_terms": [], "name": "BORCS8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019322": {"description": "Mitochondrial import inner membrane translocase subunit Tim29", "go_ids": ["GO:0042721"], "go_terms": ["GO:0042721:TIM22 mitochondrial import inner membrane insertion complex:C"], "name": "TIMM29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019323": {"description": "ELKS/Rab6-interacting/CAST family member 1", "go_ids": [], "go_terms": [], "name": "ELKS/CAST", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019324": {"description": "M-phase phosphoprotein 6", "go_ids": [], "go_terms": [], "name": "MPP6", "pathway_ids": ["R-MMU-9930044", "R-CEL-9930044", "R-CEL-6791226", "R-MMU-6791226", "R-HSA-9930044", "R-SPO-9930044", "R-SPO-6791226", "R-HSA-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-SPO-9930044:r:Nuclear RNA decay", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR019325": {"description": "NEDD4/Bsd2", "go_ids": ["GO:0030001", "GO:0007034"], "go_terms": ["GO:0030001:metal ion transport:P", "GO:0007034:vacuolar transport:P"], "name": "NEDD4/Bsd2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019326": {"description": "Protein NDNF", "go_ids": [], "go_terms": [], "name": "NDNF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019327": {"description": "WKF domain", "go_ids": [], "go_terms": [], "name": "WKF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019328": {"description": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit H, conserved domain", "go_ids": [], "go_terms": [], "name": "PIGH-H_dom", "pathway_ids": ["R-HSA-162710", "R-SPO-162710", "R-MMU-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Domain"}, "IPR019329": {"description": "NADH:ubiquinone oxidoreductase, ESSS subunit", "go_ids": [], "go_terms": [], "name": "NADH_UbQ_OxRdtase_ESSS_su", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR019330": {"description": "LRP chaperone MESD", "go_ids": ["GO:0006457"], "go_terms": ["GO:0006457:protein folding:P"], "name": "MESD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019331": {"description": "FAM192A/Fyv6, N-terminal", "go_ids": [], "go_terms": [], "name": "FAM192A/Fyv6_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019332": {"description": "Organic solute carrier protein 1", "go_ids": [], "go_terms": [], "name": "OSCP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019333": {"description": "Integrator complex subunit 3, N-terminal", "go_ids": [], "go_terms": [], "name": "INTS3_N", "pathway_ids": ["R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505", "R-DRE-6807505", "R-DDI-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR019334": {"description": "Transmembrane protein 170A/B/YPR153W-like", "go_ids": [], "go_terms": [], "name": "TMEM170A/B/YPR153W-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019335": {"description": "Conserved oligomeric Golgi complex subunit 7", "go_ids": ["GO:0017119", "GO:0006886"], "go_terms": ["GO:0017119:COG complex:C", "GO:0006886:intracellular protein transport:P"], "name": "COG7", "pathway_ids": ["R-RNO-6811440", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-RNO-6807878", "R-RNO-6811438", "R-HSA-6807878", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Family"}, "IPR019336": {"description": "GPR180/TMEM145, transmembrane domain", "go_ids": ["GO:0019236", "GO:0007186"], "go_terms": ["GO:0019236:response to pheromone:P", "GO:0007186:G protein-coupled receptor signaling pathway:P"], "name": "GPR180/TMEM145_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019337": {"description": "Telomere length regulation protein, 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"R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR019339": {"description": "CBF1-interacting co-repressor CIR, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CIR_N_dom", "pathway_ids": ["R-HSA-72163", "R-SPO-72163", "R-HSA-9918481", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR019340": {"description": "Histone acetyltransferases subunit 3", "go_ids": [], "go_terms": [], "name": "Histone_AcTrfase_su3", "pathway_ids": ["R-BTA-9772755", "R-DRE-5689880", "R-MMU-5689880", "R-BTA-5689880", "R-HSA-9772755", "R-HSA-5689880", "R-RNO-9772755", "R-HSA-3214847", "R-MMU-9772755", "R-RNO-5689880"], "pathways": ["R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR019341": {"description": "Alpha/gamma-adaptin-binding protein p34", "go_ids": [], "go_terms": [], "name": "Alpha/Gamma-adaptin-bd_p34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019342": {"description": "NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5", "go_ids": [], "go_terms": [], "name": "NADH_UbQ_OxRdtase_FeS-su5", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR019343": {"description": "Protein phosphatase 1 regulatory subunit 21, N-terminal", "go_ids": [], "go_terms": [], "name": "PPP1R21_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019344": {"description": "Mitochondrial F1-F0 ATP synthase subunit F, predicted", "go_ids": [], "go_terms": [], "name": "F1F0-ATPsyn_F_prd", "pathway_ids": ["R-BTA-8949613", "R-MMU-163210", "R-CEL-163210", "R-DME-8949613", "R-BTA-163210", "R-CEL-8949613", "R-RNO-163210", "R-DME-163210", "R-RNO-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-BTA-8949613:r:Cristae formation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-8949613:r:Cristae formation", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR019345": {"description": "ARMET, C-terminal", "go_ids": [], "go_terms": [], "name": "ARMET_C", "pathway_ids": ["R-CEL-114608", "R-HSA-114608", "R-BTA-114608", "R-RNO-114608", "R-DME-114608"], "pathways": ["R-CEL-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-DME-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR019346": {"description": "Large ribosomal subunit protein mL42", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL42", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-MMU-5389840", "R-HSA-5389840", "R-BTA-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR019347": {"description": "Axonemal dynein light chain", "go_ids": [], "go_terms": [], "name": "Axonemal_dynein_light_chain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019348": {"description": "Protein phosphatase 1 regulatory subunit 21, six-helix bundle", "go_ids": [], "go_terms": [], "name": "PPP1R21_six_helix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019349": {"description": "Small ribosomal subunit protein mS35, mitochondrial, conserved domain", "go_ids": [], "go_terms": [], "name": "Ribosomal_mS35_mit", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-DRE-5389840", "R-BTA-9937383", "R-DRE-5419276"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial 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"R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-GGA-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism"], "type": "Family"}, "IPR019363": {"description": "Lipid droplet-associated hydrolase", "go_ids": ["GO:0005811", "GO:0016298", "GO:0019915"], "go_terms": ["GO:0005811:lipid droplet:C", "GO:0016298:lipase activity:F", "GO:0019915:lipid storage:P"], "name": "LDAH", "pathway_ids": ["PWY-8412", "PWY-7424", "PWY-8411"], "pathways": ["PWY-8412:t:representative whole plasma DHA-derived icosanoids", "PWY-7424:t:sterol:steryl ester interconversion (yeast)", "PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II"], "type": "Family"}, "IPR019364": {"description": "Mediator complex, subunit Med8, fungi/metazoa", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediatior_Med8_fun/met", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR019365": {"description": "TVP18/Calcium channel flower", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "TVP18/Ca-channel_flower", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019366": {"description": "Clusterin-associated protein-1", "go_ids": [], "go_terms": [], "name": "Clusterin-associated_protein-1", "pathway_ids": ["R-CEL-5620924", "R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR019367": {"description": "PDZ-binding protein, CRIPT", "go_ids": [], "go_terms": [], "name": "PDZ-binding_CRIPT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019368": {"description": "Small ribosomal subunit protein mS29", "go_ids": [], "go_terms": [], "name": "Ribosomal_mS29", "pathway_ids": ["R-MMU-5419276", "R-MMU-9937383", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Family"}, "IPR019369": {"description": "Protein-lysine N-methyltransferase Efm5/EEF1AKMT1", "go_ids": ["GO:0016279"], "go_terms": ["GO:0016279:protein-lysine N-methyltransferase activity:F"], "name": "Efm5/EEF1AKMT1", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-SCE-8876725", "R-HSA-8876725", "R-DRE-8876725", "R-CEL-8876725", "R-GGA-8876725", "R-DDI-8876725", "R-MMU-8876725", 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"PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin 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methylation", "R-DRE-8876725:r:Protein methylation", "R-CEL-8876725:r:Protein methylation", "R-GGA-8876725:r:Protein methylation", "R-DDI-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation", "R-DME-8876725:r:Protein methylation"], "type": "Family"}, "IPR019370": {"description": "E2F-associated phosphoprotein", "go_ids": [], "go_terms": [], "name": "E2F-assoc_phosphoprotein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019371": {"description": "KxDL domain", "go_ids": [], "go_terms": [], "name": "KxDL_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019372": {"description": "Lipoma HMGIC fusion partner-like protein", "go_ids": [], "go_terms": [], "name": "LHFPL", "pathway_ids": ["R-HSA-114608", "R-DRE-114608", "R-HSA-9662361", "R-HSA-9662360", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR019373": {"description": "Large ribosomal subunit protein mL51", "go_ids": ["GO:0003735"], "go_terms": ["GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_mL51", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-CEL-5389840", "R-HSA-9937383", "R-DRE-5389840", "R-BTA-9937383", "R-BTA-5389840", "R-CEL-9937383", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-DME-9937383", "R-DRE-5419276"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR019374": {"description": "Small ribosomal subunit protein mS22", "go_ids": [], "go_terms": [], "name": "Ribosomal_mS22", "pathway_ids": ["R-MMU-5419276", "R-MMU-9937383", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Family"}, "IPR019375": {"description": "Small ribosomal subunit protein bS1m", "go_ids": [], "go_terms": [], "name": "Ribosomal_bS1m", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-BTA-9937383", "R-MMU-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation 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electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR019378": {"description": "GDP-fucose protein O-fucosyltransferase", "go_ids": [], "go_terms": [], "name": "GDP-Fuc_O-FucTrfase", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-DME-5173214", "R-HSA-5173214", "R-HSA-1912399", "R-CEL-5173214", "R-MMU-5173214"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-DME-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-CEL-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Family"}, "IPR019379": {"description": "Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit", "go_ids": [], "go_terms": [], "name": "Gamma_Secretase_Asp_P_PEN2", "pathway_ids": ["R-MMU-9839383", "R-HSA-2122948", "R-MMU-3928665", "R-RNO-9017802", "R-HSA-1251985", "R-HSA-977225", "R-BTA-9839383", "R-DRE-193692", "R-RNO-193692", "R-CEL-1251985", "R-HSA-9017802", "R-MMU-193692", "R-DRE-9839383", "R-HSA-2979096", "R-HSA-9013700", "R-MMU-9013507", "R-BTA-1251985", "R-RNO-3928665", "R-RNO-205043", "R-DME-3928665", "R-HSA-9013507", "R-DME-1251985", "R-MMU-205043", "R-RNO-1251985", "R-HSA-205043", "R-HSA-2894862", "R-RNO-9839383", "R-RNO-9013507", "R-HSA-9839383", "R-MMU-9017802", "R-CEL-3928665", "R-MMU-1251985", "R-BTA-193692", "R-HSA-3928665", "R-DRE-3928665", "R-HSA-2644606", "R-BTA-3928665", "R-BTA-205043", "R-DRE-1251985", "R-HSA-193692"], "pathways": ["R-MMU-9839383:r:TGFBR3 PTM regulation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-9839383:r:TGFBR3 PTM regulation", "R-DRE-193692:r:Regulated proteolysis of p75NTR", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-DRE-9839383:r:TGFBR3 PTM regulation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-BTA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-193692:r:Regulated proteolysis of p75NTR"], "type": "Family"}, "IPR019380": {"description": "Casein kinase substrate, phosphoprotein PP28", "go_ids": [], "go_terms": [], "name": "Casein_kinase_sb_PP28", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-RNO-6798695", "R-DDI-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR019381": {"description": "Phosphofurin acidic cluster sorting protein 1/2, C-terminal", "go_ids": [], "go_terms": [], "name": "PACS1/2_C", "pathway_ids": ["R-HSA-164940"], "pathways": ["R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression"], "type": "Domain"}, "IPR019382": {"description": "Translation initiation factor 3 complex subunit L", "go_ids": ["GO:0005737", "GO:0003743", "GO:0005852"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0003743:translation initiation factor activity:F", "GO:0005852:eukaryotic translation initiation factor 3 complex:C"], "name": "eIF3l", "pathway_ids": ["R-DME-156827", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-CEL-72695", "R-XTR-72702", "R-GGA-72702", "R-HSA-156827", "R-MMU-72649", "R-HSA-72695", "R-BTA-72689", "R-MMU-72706", "R-BTA-72695", "R-MMU-72695", "R-XTR-72695", "R-DRE-156827", "R-DME-72695", "R-BTA-156827", "R-MMU-72702", "R-DRE-72695", "R-DDI-72702", "R-DDI-72695", "R-XTR-156827", "R-BTA-72702", "R-DME-72689", "R-HSA-72706", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-CEL-156827", "R-GGA-72649", "R-DRE-72649", "R-DRE-72702", "R-DRE-72689", "R-CEL-72649", "R-DME-72702", "R-BTA-72649", "R-GGA-72695", "R-DDI-156827", "R-CEL-72689", "R-DDI-72689"], "pathways": ["R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-GGA-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72649:r:Translation initiation complex formation", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-GGA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Family"}, "IPR019383": {"description": "Golgin subfamily A member 7/ERF4", "go_ids": [], "go_terms": [], "name": "Golgin_A_7/ERF4", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-GGA-9648002", "R-MMU-9648002", "R-HSA-9694548", "R-BTA-9648002", "R-SCE-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-RNO-9648002", "R-HSA-9648002", "R-GGA-6798695", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-GGA-9648002:r:RAS processing", "R-MMU-9648002:r:RAS processing", "R-HSA-9694548:r:Maturation of spike protein", "R-BTA-9648002:r:RAS processing", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-9648002:r:RAS processing", "R-HSA-9648002:r:RAS processing", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR019384": {"description": "FHF complex subunit HOOK interacting protein", "go_ids": [], "go_terms": [], "name": "FHIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019385": {"description": "Phosphorylated adapter RNA export protein, RNA-binding domain", "go_ids": [], "go_terms": [], "name": "PHAX_RNA-binding_domain", "pathway_ids": ["R-HSA-6807505", "R-RNO-6807505", "R-HSA-191859", "R-BTA-6807505", "R-MMU-6807505"], "pathways": ["R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-191859:r:snRNP Assembly", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR019387": {"description": "SAYSvFN domain", "go_ids": [], "go_terms": [], "name": "SAYSvFN_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019388": {"description": "Fat storage-inducing transmembrane protein", "go_ids": ["GO:0010945", "GO:0005789", "GO:0019915"], "go_terms": ["GO:0010945:coenzyme A diphosphatase activity:F", "GO:0005789:endoplasmic reticulum membrane:C", "GO:0019915:lipid storage:P"], "name": "FIT", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-8964572", "R-CEL-8964572", "R-SSC-8964572", "R-MMU-8964572", "R-SPO-8964572", "R-SCE-8964572", "R-BTA-8964572", "R-DME-8964572", "R-DRE-8964572"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-8964572:r:Lipid particle organization", "R-CEL-8964572:r:Lipid particle organization", "R-SSC-8964572:r:Lipid particle organization", "R-MMU-8964572:r:Lipid particle organization", "R-SPO-8964572:r:Lipid particle organization", "R-SCE-8964572:r:Lipid particle organization", "R-BTA-8964572:r:Lipid particle organization", "R-DME-8964572:r:Lipid particle organization", "R-DRE-8964572:r:Lipid particle organization"], "type": "Family"}, "IPR019389": {"description": "Selenoprotein T", "go_ids": [], "go_terms": [], "name": "Selenoprotein_T", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019391": {"description": "Storkhead-box protein, winged-helix domain", "go_ids": [], "go_terms": [], "name": "Storkhead-box_WHD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019392": {"description": "Mitoguardin", "go_ids": ["GO:0008053"], "go_terms": ["GO:0008053:mitochondrial fusion:P"], "name": "Miga", "pathway_ids": ["R-BTA-1483166", "R-MMU-1483166", "R-DRE-1483166", "R-HSA-1483166", "R-DME-1483166"], "pathways": ["R-BTA-1483166:r:Synthesis of PA", "R-MMU-1483166:r:Synthesis of PA", "R-DRE-1483166:r:Synthesis of PA", "R-HSA-1483166:r:Synthesis of PA", "R-DME-1483166:r:Synthesis of PA"], "type": "Family"}, "IPR019393": {"description": "WASH complex, subunit strumpellin", "go_ids": ["GO:0071203"], "go_terms": ["GO:0071203:WASH complex:C"], "name": "WASH_strumpellin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019394": {"description": "Testis-specific protein TEX28/transmembrane and coiled-coil domains protein", "go_ids": [], "go_terms": [], "name": "TEX28/TMCC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019395": {"description": "Transmembrane protein 161A/B", "go_ids": [], "go_terms": [], "name": "Transmembrane_161A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019396": {"description": "Transmembrane Fragile-X-F-associated protein", "go_ids": [], "go_terms": [], "name": "TM_Fragile-X-F-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019397": {"description": "Uncharacterised protein family TMEM39", "go_ids": [], "go_terms": [], "name": "Uncharacterised_TMEM39", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019398": {"description": "Pre-rRNA-processing protein TSR2", "go_ids": [], "go_terms": [], "name": "Pre-rRNA_process_TSR2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019399": {"description": "Parkin co-regulated protein", "go_ids": [], "go_terms": [], "name": "Parkin_co-regulated_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019400": {"description": "Peptidase C65, otubain", "go_ids": [], "go_terms": [], "name": "Peptidase_C65_otubain", "pathway_ids": ["R-MMU-5689880", "R-DME-5689896", "R-HSA-5689896", "R-HSA-5689880", "R-RNO-5689896", "R-MMU-5689896", "R-CEL-5689896", "R-DME-5689880", "R-RNO-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-DME-5689880:r:Ub-specific processing proteases", "R-RNO-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR019401": {"description": "Zinc finger, CHCC-type", "go_ids": [], "go_terms": [], "name": "Znf_CHCC", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-MMU-6799198", "R-HSA-6799198", "R-MMU-611105", "R-RNO-6799198", "R-BTA-6799198", "R-BTA-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-6799198:r:Complex I biogenesis", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR019402": {"description": "CWH43-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CWH43_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019403": {"description": "Mediator complex, subunit Med19, metazoa", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med19_met", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR019404": {"description": "Mediator complex, subunit Med11", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med11", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR019405": {"description": "Lactonase, 7-bladed beta-propeller", "go_ids": [], "go_terms": [], "name": "Lactonase_7-beta_prop", "pathway_ids": ["PWY-8004"], "pathways": ["PWY-8004:t:Entner-Doudoroff pathway I"], "type": "Family"}, "IPR019406": {"description": "Aprataxin and PNK-like factor, PBZ domain", "go_ids": [], "go_terms": [], "name": "APLF_PBZ", "pathway_ids": ["R-DDI-6798695", "R-DDI-5693571"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Domain"}, "IPR019407": {"description": "Cytoplasmic tRNA 2-thiolation protein 2", "go_ids": ["GO:0002098", "GO:0034227", "GO:0000049"], "go_terms": ["GO:0002098:tRNA wobble uridine modification:P", "GO:0034227:tRNA thio-modification:P", "GO:0000049:tRNA binding:F"], "name": "CTU2", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR019408": {"description": "7TM GPCR, serpentine receptor class ab (Srab)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Srab", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019410": {"description": "Lysine methyltransferase", "go_ids": [], "go_terms": [], "name": "Methyltransf_16", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-SCE-8876725", "R-HSA-8876725", "R-DRE-8876725", "R-HSA-9821993", "R-HSA-2514859", "R-XTR-8876725", "R-HSA-9821002", "R-MMU-2514859", "R-RNO-8876725", "R-RNO-2514859", "R-CEL-8876725", "R-SPO-8876725", "R-BTA-8876725", "R-DDI-8876725", "R-MMU-8876725"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-SCE-8876725:r:Protein methylation", "R-HSA-8876725:r:Protein methylation", "R-DRE-8876725:r:Protein methylation", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-XTR-8876725:r:Protein methylation", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-8876725:r:Protein methylation", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-8876725:r:Protein methylation", "R-SPO-8876725:r:Protein methylation", "R-BTA-8876725:r:Protein methylation", "R-DDI-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation"], "type": "Family"}, "IPR019411": {"description": "MMM1 domain", "go_ids": [], "go_terms": [], "name": "MMM1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019412": {"description": "IML2-like/Tetratricopeptide repeat protein 39-like", "go_ids": [], "go_terms": [], "name": "IML2/TPR_39", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019413": {"description": "DSC E3 ubiquitin ligase complex subunit 3, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "Dsc3_ub-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019414": {"description": "RNA polymerase II assembly factor Rtp1, C-terminal domain 2", "go_ids": [], "go_terms": [], "name": "Rtp1_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019415": {"description": "FMP27, SW motif-containing RBG unit", "go_ids": [], "go_terms": [], "name": "FMP27_SW_RBG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019416": {"description": "Nuclear cap-binding protein subunit 3", "go_ids": ["GO:0003729", "GO:0000340"], "go_terms": ["GO:0003729:mRNA binding:F", "GO:0000340:RNA 7-methylguanosine cap binding:F"], "name": "NCBP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019417": {"description": "Domain of unknown function DUF2415", "go_ids": [], "go_terms": [], "name": "DUF2415", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019419": {"description": "Altered inheritance of mitochondria protein 19", "go_ids": [], "go_terms": [], "name": "AIM19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019420": {"description": "7TM GPCR, serpentine receptor class bc (Srbc)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Srbc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019421": {"description": "7TM GPCR, serpentine receptor class d (Srd)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Srd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019422": {"description": "7TM GPCR, serpentine receptor class h (Srh)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Srh", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019423": {"description": "7TM GPCR, serpentine receptor class j (Srj)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Srj", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019424": {"description": "Serpentine type 7TM GPCR chemoreceptor Srsx", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_Srsx", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019425": {"description": "7TM GPCR, serpentine receptor class t (Srt)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Srt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019426": {"description": "7TM GPCR, serpentine receptor class v (Srv)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Srv", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019427": {"description": "7TM GPCR, serpentine receptor class w (Srw)", "go_ids": ["GO:0008528"], "go_terms": ["GO:0008528:G protein-coupled peptide receptor activity:F"], "name": "7TM_GPCR_serpentine_rcpt_Srw", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019428": {"description": "7TM GPCR, serpentine receptor class r (Str)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Str", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019429": {"description": "7TM GPCR, serpentine chemoreceptor class i (Sri)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Sri", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019430": {"description": "7TM GPCR, serpentine receptor class x (Srx)", "go_ids": [], "go_terms": [], "name": "7TM_GPCR_serpentine_rcpt_Srx", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019431": {"description": "Protein of unknown function DUF2417", "go_ids": [], "go_terms": [], "name": "DUF2417", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019432": {"description": "Acyltransferase MbtK/IucB-like, conserved domain", "go_ids": ["GO:0019290", "GO:0016746"], "go_terms": ["GO:0019290:siderophore biosynthetic process:P", "GO:0016746:acyltransferase activity:F"], "name": "Acyltransferase_MbtK/IucB-like", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR019433": {"description": "GPI-Mannosyltransferase II co-activator, Pga1", "go_ids": [], "go_terms": [], "name": "GPI_ManTrfase_II_coact_Pga1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019434": {"description": "Domain of unknown function DUF2423", "go_ids": [], "go_terms": [], "name": "DUF2423", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019435": {"description": "Velum formation protein 1-like", "go_ids": [], "go_terms": [], "name": "Vel1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019436": {"description": "Steryl acetyl hydrolase 1-like", "go_ids": [], "go_terms": [], "name": "Say1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019437": {"description": "Shelterin complex subunit TPP1/Est3", "go_ids": ["GO:0000781", "GO:0005697", "GO:0007004", "GO:0042162"], "go_terms": ["GO:0000781:chromosome, telomeric region:C", "GO:0005697:telomerase holoenzyme complex:C", "GO:0007004:telomere maintenance via telomerase:P", "GO:0042162:telomeric repeat DNA binding:F"], "name": "TPP1/Est3", "pathway_ids": ["R-RNO-2559586", "R-MMU-174430", "R-RNO-174437", "R-MMU-110330", "R-HSA-171306", "R-HSA-174414", "R-MMU-2559586", "R-MMU-174417", "R-RNO-174430", "R-HSA-174430", "R-RNO-110331", "R-HSA-110328", "R-HSA-1221632", "R-HSA-174411", "R-RNO-171319", "R-MMU-110331", "R-MMU-9670095", "R-MMU-171319", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-MMU-174437", "R-RNO-110330", "R-RNO-174417", "R-HSA-110329", "R-HSA-110330", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586", "R-RNO-174411", "R-RNO-174414"], "pathways": ["R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere"], "type": "Domain"}, "IPR019438": {"description": "Queuosine salvage protein family", "go_ids": [], "go_terms": [], "name": "Q_salvage", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-6782315", "R-MMU-6782315", "R-DDI-6782315", "R-SPO-6782315"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-MMU-6782315:r:tRNA modification in the nucleus and cytosol", "R-DDI-6782315:r:tRNA modification in the nucleus and cytosol", "R-SPO-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR019440": {"description": "Chromatid cohesion factor MAU2", "go_ids": ["GO:0007064"], "go_terms": ["GO:0007064:mitotic sister chromatid cohesion:P"], "name": "MAU2", "pathway_ids": ["R-CEL-2470946", "R-HSA-2470946", "R-SPO-2470946", "R-MMU-2470946", "R-DME-2470946"], "pathways": ["R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-DME-2470946:r:Cohesin Loading onto Chromatin"], "type": "Family"}, "IPR019441": {"description": "FMP27/BLTP2/Hobbit, GFWDK motif-containing RBG unit", "go_ids": [], "go_terms": [], "name": "FMP27/BLTP2/Hobbit_GFWDK_RBG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019442": {"description": "THADA/TRM732, DUF2428", "go_ids": [], "go_terms": [], "name": "THADA/TRM732_DUF2428", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR019445": {"description": "Uncharacterised protein family UPF0321", "go_ids": [], "go_terms": [], "name": "UPF0321", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019446": {"description": "25S rRNA (uridine-N(3))-methyltransferase BMT5-like", "go_ids": ["GO:0070475", "GO:0070042"], "go_terms": ["GO:0070475:rRNA base methylation:P", "GO:0070042:rRNA (uridine-N3-)-methyltransferase activity:F"], "name": "BMT5-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019447": {"description": "DNA/RNA-binding protein Kin17, WH-like domain", "go_ids": [], "go_terms": [], "name": "DNA/RNA-bd_Kin17_WH-like_dom", "pathway_ids": ["R-HSA-8876725", "R-MMU-8876725"], "pathways": ["R-HSA-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation"], "type": "Domain"}, "IPR019448": {"description": "NT-type C2 domain", "go_ids": [], "go_terms": [], "name": "NT-C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019449": {"description": "FMP27, WPPW motif-containing RBG unit", "go_ids": [], "go_terms": [], "name": "FMP27_WPPW_RBG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019451": {"description": "RNA polymerase II assembly factor Rtp1, C-terminal", "go_ids": [], "go_terms": [], "name": "Rtp1_C1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019452": {"description": "Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1", "go_ids": [], "go_terms": [], "name": "VPS39/TGF_beta_rcpt-assoc_1", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR019453": {"description": "Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated zinc finger domain", "go_ids": [], "go_terms": [], "name": "VPS39/TGFA1_Znf", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR019454": {"description": "Putative cell-wall binding lipoprotein YkyA-like", "go_ids": [], "go_terms": [], "name": "Lipoprot_YkyA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019455": {"description": "Acetolactate synthase, small subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "Acetolactate_synth_ssu_C", "pathway_ids": ["PWY-7111", "PWY-6389", "PWY-5938", "PWY-5101", "PWY-5103", "PWY-5104", "PWY-5939"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-6389:t:pyruvate fermentation to (S)-acetoin", "PWY-5938:t:pyruvate fermentation to (R)-acetoin I", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-5103:t:L-isoleucine biosynthesis III", "PWY-5104:t:L-isoleucine biosynthesis IV", "PWY-5939:t:pyruvate fermentation to (R)-acetoin II"], "type": "Domain"}, "IPR019456": {"description": "Pyruvate-flavodoxin oxidoreductase, EKR domain", "go_ids": ["GO:0016903"], "go_terms": ["GO:0016903:oxidoreductase activity, acting on the aldehyde or oxo group of donors:F"], "name": "Pyrv-flavodox_OxRtase_EKR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019457": {"description": "Diadenylate cyclase CdaS, N-terminal", "go_ids": [], "go_terms": [], "name": "CdaS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019458": {"description": "Telomerase activating protein Est1-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Est1-like_N", "pathway_ids": ["R-HSA-975957", "R-SPO-975957", "R-DRE-975957", "R-SCE-975957", "R-MMU-975957"], "pathways": ["R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Domain"}, "IPR019459": {"description": "GRIP-related Arf-binding domain", "go_ids": [], "go_terms": [], "name": "GRAB", "pathway_ids": ["R-SCE-6811438", "R-SPO-6811438"], "pathways": ["R-SCE-6811438:r:Intra-Golgi traffic", "R-SPO-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR019460": {"description": "Autophagy-related protein 11, C-terminal", "go_ids": [], "go_terms": [], "name": "Atg11_C", "pathway_ids": ["R-SCE-1632852", "R-SPO-1632852", "R-HSA-1632852", "R-MMU-1632852"], "pathways": ["R-SCE-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy"], "type": "Domain"}, "IPR019462": {"description": "DNA-directed RNA polymerase, beta subunit, external 1 domain", "go_ids": ["GO:0003899", "GO:0006351"], "go_terms": ["GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "DNA-dir_RNA_pol_bsu_external_1", "pathway_ids": ["R-HSA-9639775"], "pathways": ["R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb"], "type": "Domain"}, "IPR019464": {"description": "RNA polymerase II elongation factor ELL, N-terminal", "go_ids": ["GO:0006368", "GO:0008023"], "go_terms": ["GO:0006368:transcription elongation by RNA polymerase II:P", "GO:0008023:transcription elongation factor complex:C"], "name": "ELL_N", "pathway_ids": ["R-MMU-6796648", "R-HSA-6807505", "R-HSA-6781827", "R-HSA-167238", "R-RNO-6807505", "R-HSA-167243", "R-DME-674695", "R-DME-6796648", "R-HSA-6796648", "R-DME-75955", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-MMU-6807505", "R-DME-351906", "R-HSA-167287", "R-DME-6807505", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-75955", "R-HSA-167152", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR019465": {"description": "Conserved oligomeric Golgi complex subunit 5", "go_ids": ["GO:0017119", "GO:0006891"], "go_terms": ["GO:0017119:COG complex:C", "GO:0006891:intra-Golgi vesicle-mediated transport:P"], "name": "Cog5", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-HSA-6807878", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Family"}, "IPR019466": {"description": "Matrilin, coiled-coil trimerisation domain", "go_ids": [], "go_terms": [], "name": "Matrilin_CC_trimer", "pathway_ids": ["R-HSA-381426", "R-HSA-8957275", "R-GGA-381426", "R-MMU-8957275", "R-MMU-381426", "R-HSA-3000178", "R-GGA-8957275"], "pathways": ["R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3000178:r:ECM proteoglycans", "R-GGA-8957275:r:Post-translational protein phosphorylation"], "type": "Domain"}, "IPR019467": {"description": "Histone acetyl transferase HAT1 N-terminal", "go_ids": ["GO:0006325"], "go_terms": ["GO:0006325:chromatin organization:P"], "name": "Hat1_N", "pathway_ids": ["R-MMU-3214847", "R-SCE-3214847", "R-HSA-3214847", "R-RNO-3214847", "R-SPO-3214847", "R-DDI-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-SCE-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-3214847:r:HATs acetylate histones", "R-SPO-3214847:r:HATs acetylate histones", "R-DDI-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR019468": {"description": "Adenylosuccinate lyase C-terminal", "go_ids": [], "go_terms": [], "name": "AdenyloSucc_lyase_C", "pathway_ids": ["PWY-7219", "PWY-7234", "PWY-6124", "PWY-6123", "PWY-8289", "R-SPO-73817", "R-MMU-73817", "R-SCE-73817", "R-CEL-73817", "R-HSA-73817", "R-GGA-421203", "R-GGA-73817", "R-GGA-419140"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "PWY-7234:t:inosine-5'-phosphate biosynthesis III", "PWY-6124:t:inosine-5'-phosphate biosynthesis II", "PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-8289:t:dZTP biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-421203:r:De novo synthesis of AMP", "R-GGA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Domain"}, "IPR019469": {"description": "Protein of unknown function DUF2443", "go_ids": [], "go_terms": [], "name": "DUF2443", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019470": {"description": "Ubiquitinol-cytochrome C reductase, Fe-S subunit, TAT signal", "go_ids": ["GO:0008121"], "go_terms": ["GO:0008121:quinol-cytochrome-c reductase activity:F"], "name": "Ubiq_cytC_Rdtase_Fe-S_su_TAT", "pathway_ids": ["PWY-7279", "PWY-6692", "PWY-3781"], "pathways": ["PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "PWY-6692:t:Fe(II) oxidation", "PWY-3781:t:aerobic respiration I (cytochrome c)"], "type": "Domain"}, "IPR019471": {"description": "Interferon regulatory factor-3", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Interferon_reg_factor-3", "pathway_ids": ["R-HSA-9833109", "R-SSC-3134973", "R-HSA-1606341", "R-GGA-933541", "R-MMU-933541", "R-HSA-9705671", "R-HSA-168928", "R-SSC-936964", "R-SSC-3270619", "R-BTA-918233", "R-HSA-936440", "R-MMU-9013973", "R-HSA-1169408", "R-MMU-3134963", "R-HSA-936964", "R-HSA-918233", "R-SSC-3134975", "R-HSA-3134963", "R-BTA-3270619", "R-BTA-936440", "R-MMU-918233", "R-SSC-918233", "R-SSC-1169408", "R-BTA-936964", "R-GGA-434136", "R-MMU-975110", "R-MMU-909733", "R-GGA-1227882", "R-GGA-936964", "R-MMU-936964", "R-BTA-1606341", "R-HSA-3270619", "R-GGA-975110", "R-MMU-168928", "R-MMU-3270619", "R-SSC-933541", "R-HSA-9013973", "R-SSC-1606341", "R-GGA-9013973", "R-MMU-3134975", "R-BTA-3134973", "R-GGA-3134963", "R-MMU-3134973", "R-HSA-6785807", "R-MMU-1169408", "R-BTA-933541", "R-MMU-9860276", "R-HSA-9824585", "R-BTA-9013973", "R-SSC-168928", "R-HSA-9860276", "R-HSA-9725371", "R-HSA-933541", "R-SSC-9013973", "R-HSA-909733", "R-HSA-877300", "R-HSA-9692916", "R-HSA-3134975", "R-BTA-168928", "R-SSC-936440", "R-MMU-936440", "R-HSA-975110", "R-HSA-3134973", "R-BTA-1169408", "R-GGA-433819", "R-MMU-1606341"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-SSC-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-GGA-933541:r:TRAF6 mediated IRF7 activation", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SSC-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-SSC-3270619:r:IRF3-mediated induction of type I IFN", "R-BTA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-SSC-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-BTA-3270619:r:IRF3-mediated induction of type I IFN", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-918233:r:TRAF3-dependent IRF activation pathway", "R-SSC-918233:r:TRAF3-dependent IRF activation pathway", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-434136:r:Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1", "R-MMU-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-GGA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-SSC-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-SSC-1606341:r:IRF3 mediated activation of type 1 IFN", "R-GGA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-GGA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-BTA-933541:r:TRAF6 mediated IRF7 activation", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-SSC-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-SSC-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SSC-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-GGA-433819:r:Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK", "R-MMU-1606341:r:IRF3 mediated activation of type 1 IFN"], "type": "Domain"}, "IPR019473": {"description": "Transcription factor TFIID, subunit 8, C-terminal", "go_ids": [], "go_terms": [], "name": "TFIID_su8_C", "pathway_ids": ["R-HSA-6807505", "R-MMU-75953", "R-DRE-73779", "R-XTR-76042", "R-DME-76042", "R-BTA-76042", "R-MMU-6804756", "R-DME-73779", "R-DRE-75953", "R-DRE-6807505", "R-HSA-167162", "R-DME-73776", "R-HSA-73776", "R-BTA-6804756", "R-HSA-75953", "R-MMU-73776", "R-XTR-73779", "R-DME-75953", "R-XTR-75953", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-BTA-73779", "R-DRE-6804756", "R-XTR-674695", "R-BTA-75953", "R-DRE-76042", "R-DME-674695", "R-BTA-6807505", "R-DRE-73776", "R-BTA-674695", "R-MMU-674695", "R-MMU-6807505", "R-DME-6804756", "R-HSA-167161", "R-DME-6807505", "R-HSA-6804756", "R-DRE-674695", "R-XTR-73776", "R-HSA-76042", "R-HSA-674695", "R-XTR-6804756", "R-BTA-73776", "R-XTR-6807505", "R-HSA-73779"], "pathways": ["R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-XTR-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-XTR-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-XTR-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR019474": {"description": "Ubiquitin conjugation factor E4, core", "go_ids": ["GO:0000151", "GO:0006511", "GO:0016567", "GO:0034450"], "go_terms": ["GO:0000151:ubiquitin ligase complex:C", "GO:0006511:ubiquitin-dependent protein catabolic process:P", "GO:0016567:protein ubiquitination:P", "GO:0034450:ubiquitin-ubiquitin ligase activity:F"], "name": "Ub_conjug_fac_E4_core", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-SPO-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR019475": {"description": "DNA primase, DnaB-helicase binding domain", "go_ids": ["GO:0016779"], "go_terms": ["GO:0016779:nucleotidyltransferase activity:F"], "name": "DNA_primase_DnaB-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019476": {"description": "Type IV secretion system coupling protein TraD, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "TraD_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019477": {"description": "Rhodopsin, N-terminal", "go_ids": [], "go_terms": [], "name": "Rhodopsin_N", "pathway_ids": ["R-BTA-2485179", "R-DRE-418594", "R-MMU-5620916", "R-DRE-2485179", "R-BTA-5620916", "R-HSA-2514859", "R-MMU-419771", "R-SSC-5620916", "R-HSA-419771", "R-RNO-5620916", "R-RNO-419771", "R-RNO-2485179", "R-HSA-2485179", "R-MMU-2453902", "R-DRE-2453902", "R-BTA-2514859", "R-RNO-2514859", "R-RNO-2453902", "R-SSC-419771", "R-MMU-418594", "R-RNO-418594", "R-HSA-5620916", "R-BTA-418594", "R-HSA-418594", "R-DRE-5620916", "R-BTA-419771", "R-SSC-2514859", "R-MMU-2514859", "R-SSC-418594", "R-SSC-2485179", "R-BTA-2453902", "R-MMU-2485179", "R-DRE-2514859", "R-DRE-419771", "R-SSC-2453902", "R-HSA-2453902"], "pathways": ["R-BTA-2485179:r:Activation of the phototransduction cascade", "R-DRE-418594:r:G alpha (i) signalling events", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-2485179:r:Activation of the phototransduction cascade", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-419771:r:Opsins", "R-SSC-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-419771:r:Opsins", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-419771:r:Opsins", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DRE-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SSC-419771:r:Opsins", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-DRE-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-419771:r:Opsins", "R-SSC-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SSC-418594:r:G alpha (i) signalling events", "R-SSC-2485179:r:Activation of the phototransduction cascade", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-DRE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DRE-419771:r:Opsins", "R-SSC-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Domain"}, "IPR019478": {"description": "Sirohaem synthase, dimerisation domain", "go_ids": ["GO:0006779"], "go_terms": ["GO:0006779:porphyrin-containing compound biosynthetic process:P"], "name": "Sirohaem_synthase_dimer_dom", "pathway_ids": ["PWY-5196", "PWY-5194", "PWY-7377"], "pathways": ["PWY-5196:t:factor 430 biosynthesis", "PWY-5194:t:siroheme biosynthesis", "PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Domain"}, "IPR019479": {"description": "Peroxiredoxin, C-terminal", "go_ids": ["GO:0051920"], "go_terms": ["GO:0051920:peroxiredoxin activity:F"], "name": "Peroxiredoxin_C", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-SSC-6798695", "R-SCE-5628897", "R-GGA-3000471", "R-SCE-6798695", "R-BTA-6798695", "R-HSA-8862803", "R-HSA-5628897", "R-RNO-3299685", "R-RNO-3000471", "R-SCE-9818027", "R-BTA-3299685", "R-HSA-3000471", "R-MMU-5628897", "R-MMU-9818027", "R-BTA-3000471", "R-CEL-9818027", "R-DDI-6798695", "R-HSA-3299685", "R-DDI-5628897", "R-GGA-3299685", "R-MMU-3000471", "R-SPO-5628897", "R-CEL-5628897", "R-RNO-5628897", "R-SSC-3299685", "R-BTA-9818027", "R-CEL-3299685", "R-MMU-3299685", "R-SPO-9818027", "R-DME-9818027", "R-BTA-5628897", "R-RNO-9818027", "R-GGA-5628897", "R-PFA-6798695", "R-DDI-9818027", "R-MMU-6798695", "R-GGA-9818027", "R-DME-3299685", "R-DME-5628897", "R-RNO-6798695", "R-HSA-9818027"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-3000471:r:Scavenging by Class B Receptors", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-SCE-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-BTA-3000471:r:Scavenging by Class B Receptors", "R-CEL-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-DME-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-PFA-6798695:r:Neutrophil degranulation", "R-DDI-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-MMU-6798695:r:Neutrophil degranulation", "R-GGA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes"], "type": "Domain"}, "IPR019480": {"description": "Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain", "go_ids": [], "go_terms": [], "name": "Dihydroorotate_DH_Fe-S-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019481": {"description": "Transcription factor TFIIIC, triple barrel domain", "go_ids": [], "go_terms": [], "name": "TFIIIC_triple_barrel", "pathway_ids": ["R-SPO-76061", "R-MMU-76061", "R-MMU-76066", "R-HSA-749476", "R-SPO-76066", "R-HSA-76066", "R-HSA-76061"], "pathways": ["R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR019482": {"description": "Interleukin-12 beta, central domain", "go_ids": [], "go_terms": [], "name": "IL-12_beta_cen-dom", "pathway_ids": ["R-SSC-9020933", "R-MMU-9020933", "R-HSA-9020591", "R-MMU-9020591", "R-HSA-6785807", "R-HSA-6783783", "R-SSC-9020591", "R-HSA-9020933"], "pathways": ["R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020933:r:Interleukin-23 signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-HSA-9020933:r:Interleukin-23 signaling"], "type": "Domain"}, "IPR019485": {"description": "V(D)J recombination-activating protein 1, Zinc finger", "go_ids": [], "go_terms": [], "name": "RAG1_Znf", "pathway_ids": ["PWY-7511", "R-HSA-1266695", "R-HSA-5687128"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Domain"}, "IPR019486": {"description": "Argonaute hook domain", "go_ids": [], "go_terms": [], "name": "Argonaute_hook_dom", "pathway_ids": ["R-HSA-8853884", "R-HSA-9022692", "R-MMU-426496", "R-HSA-2559580", "R-HSA-8936459", "R-HSA-5578749", "R-HSA-2559585", "R-HSA-8948700", "R-DME-5578749", "R-HSA-5628897", "R-HSA-9764562", "R-HSA-1912408", "R-HSA-9759811", "R-HSA-4086398", "R-HSA-9029569", "R-HSA-9824594", "R-HSA-9018519", "R-MMU-5578749", "R-HSA-9839394", "R-HSA-8943723", "R-HSA-8934593", "R-HSA-9725371", "R-HSA-9768778", "R-HSA-5687128", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-426496", "R-DME-426496"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426496:r:Post-transcriptional silencing by small RNAs"], "type": "Domain"}, "IPR019487": {"description": "RAM signalling pathway, SOG2", "go_ids": [], "go_terms": [], "name": "RAM_signalling_pathway_SOG2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019488": {"description": "Nuclear pore RNA shuttling protein Mtr2", "go_ids": [], "go_terms": [], "name": "Nucl_pore_RNA_shuttling_Mtr2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019489": {"description": "Clp ATPase, C-terminal", "go_ids": [], "go_terms": [], "name": "Clp_ATPase_C", "pathway_ids": ["R-HSA-9837999", "R-MMU-9837999", "R-RNO-9837999"], "pathways": ["R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation"], "type": "Domain"}, "IPR019490": {"description": "Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase, C-terminal", "go_ids": ["GO:0005975", "GO:0004476", "GO:0004347"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0004476:mannose-6-phosphate isomerase activity:F", "GO:0004347:glucose-6-phosphate isomerase activity:F"], "name": "Glu6P/Mann6P_isomerase_C", "pathway_ids": ["PWY-7385", "PWY-5659", "PWY-5514", "PWY-6142", "PWY-7456", "PWY-7238", "PWY-3861", "PWY-622", "PWY-621", "PWY-6992", "PWY-7347", "PWY-7586", "PWY-6981", "PWY-5384", "PWY-8013", "PWY-3881", "PWY-3801", "PWY-5054"], "pathways": ["PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5659:t:GDP-mannose biosynthesis", "PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-7456:t:beta-(1,4)-mannan degradation", "PWY-7238:t:sucrose biosynthesis II", "PWY-3861:t:mannitol degradation II", "PWY-622:t:starch biosynthesis", "PWY-621:t:sucrose degradation III (sucrose invertase)", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7347:t:sucrose biosynthesis III", "PWY-7586:t:beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation", "PWY-6981:t:chitin biosynthesis", "PWY-5384:t:sucrose degradation IV (sucrose phosphorylase)", "PWY-8013:t:UDP-N-acetyl-D-galactosamine biosynthesis III", "PWY-3881:t:mannitol biosynthesis", "PWY-3801:t:sucrose degradation II (sucrose synthase)", "PWY-5054:t:D-sorbitol biosynthesis I"], "type": "Domain"}, "IPR019491": {"description": "Lipoate protein ligase, C-terminal", "go_ids": [], "go_terms": [], "name": "Lipoate_protein_ligase_C", "pathway_ids": ["R-PFA-9857492"], "pathways": ["R-PFA-9857492:r:Protein lipoylation"], "type": "Domain"}, "IPR019492": {"description": "Cyclo-malto-dextrinase, C-terminal", "go_ids": [], "go_terms": [], "name": "Cyclo-malto-dextrinase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019493": {"description": "Bacteriocin, class IIb, lactacin-related", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense response to bacterium:P"], "name": "Bacteriocin_IIb_lactacin-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019494": {"description": "FIST, C-domain", "go_ids": [], "go_terms": [], "name": "FIST_C", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR019495": {"description": "Exosome complex component CSL4, C-terminal", "go_ids": ["GO:0003723", "GO:0000178"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0000178:exosome (RNase complex):C"], "name": "EXOSC1_C", "pathway_ids": ["R-MMU-9930044", "R-MMU-450385", "R-MMU-6791226", "R-HSA-9930044", "R-SCE-450513", "R-MMU-429958", "R-SPO-9930044", "R-SCE-450385", "R-HSA-450385", "R-SCE-429958", "R-HSA-380994", "R-MMU-450513", "R-SCE-6791226", "R-HSA-6791226", "R-MMU-450604", "R-HSA-450513", "R-HSA-450604", "R-HSA-429958", "R-SPO-429958", "R-SPO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR019496": {"description": "FMR1-interacting protein 1, conserved domain", "go_ids": [], "go_terms": [], "name": "NUFIP1_cons_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019497": {"description": "Sorting nexin protein, WASP-binding domain", "go_ids": [], "go_terms": [], "name": "Sorting_nexin_WASP-bd-dom", "pathway_ids": ["R-CEL-8856828", "R-CEL-432722", "R-MMU-8856828", "R-HSA-432722", "R-HSA-8856828", "R-MMU-432722"], "pathways": ["R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR019498": {"description": "MENTAL domain", "go_ids": [], "go_terms": [], "name": "MENTAL", "pathway_ids": ["R-MMU-196108", "R-DRE-196108", "R-HSA-196108"], "pathways": ["R-MMU-196108:r:Pregnenolone biosynthesis", "R-DRE-196108:r:Pregnenolone biosynthesis", "R-HSA-196108:r:Pregnenolone biosynthesis"], "type": "Domain"}, "IPR019499": {"description": "Valyl-tRNA synthetase, tRNA-binding arm", "go_ids": ["GO:0000166", "GO:0004832", "GO:0005524", "GO:0005737", "GO:0006438"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004832:valine-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006438:valyl-tRNA aminoacylation:P"], "name": "Val-tRNA_synth_tRNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019500": {"description": "Peptidase S46", "go_ids": ["GO:0008239", "GO:0070009"], "go_terms": ["GO:0008239:dipeptidyl-peptidase activity:F", "GO:0070009:serine-type aminopeptidase activity:F"], "name": "Pep_S46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019501": {"description": "Peptidase M30, hyicolysin", "go_ids": [], "go_terms": [], "name": "Peptidase_M30_hyicolysin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019502": {"description": "Peptidase S68, pidd", "go_ids": ["GO:0006915", "GO:0006974"], "go_terms": ["GO:0006915:apoptotic process:P", "GO:0006974:DNA damage response:P"], "name": "Peptidase_S68_pidd", "pathway_ids": ["R-HSA-6803207", "R-MMU-6803207"], "pathways": ["R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases"], "type": "Family"}, "IPR019504": {"description": "Peptidase U49, Lit peptidase", "go_ids": [], "go_terms": [], "name": "Peptidase_U49_Lit_pept", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019505": {"description": "Peptidase U40", "go_ids": [], "go_terms": [], "name": "Peptidase_U40", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019506": {"description": "Peptidase inhibitor, PinA", "go_ids": [], "go_terms": [], "name": "Pept-inhibitor_PinA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019507": {"description": "Protease A inhibitor IA3", "go_ids": ["GO:0004866", "GO:0010951"], "go_terms": ["GO:0004866:endopeptidase inhibitor activity:F", "GO:0010951:negative regulation of endopeptidase activity:P"], "name": "Pai3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019508": {"description": "Proteinase inhibitor I48, clitocypin", "go_ids": ["GO:0004869"], "go_terms": ["GO:0004869:cysteine-type endopeptidase inhibitor activity:F"], "name": "Prot_inh_I48_clitocypin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019509": {"description": "Carboxypeptidase inhibitor I68", "go_ids": ["GO:0010951", "GO:0007596", "GO:0008191"], "go_terms": ["GO:0010951:negative regulation of endopeptidase activity:P", "GO:0007596:blood coagulation:P", "GO:0008191:metalloendopeptidase inhibitor activity:F"], "name": "Carboxypeptidase_inhibitor_I68", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019510": {"description": "A-kinase anchor protein 7-like, phosphoesterase domain", "go_ids": [], "go_terms": [], "name": "AKAP7-like_phosphoesterase", "pathway_ids": ["R-HSA-112126"], "pathways": ["R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage"], "type": "Domain"}, "IPR019511": {"description": "A-kinase anchor protein 7, RI-RII subunit-binding domain", "go_ids": [], "go_terms": [], "name": "AKAP7_RI-RII-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019512": {"description": "Protein phosphatase 1, regulatory subunit 15B, N-terminal", "go_ids": [], "go_terms": [], "name": "Prot_Pase1_reg-su15B_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019513": {"description": "Centromere protein Cenp-F, leucine-rich repeat-containing domain", "go_ids": ["GO:0070840", "GO:0042803", "GO:0008134"], "go_terms": ["GO:0070840:dynein complex binding:F", "GO:0042803:protein homodimerization activity:F", "GO:0008134:transcription factor binding:F"], "name": "Centromere_CenpF_leu-rich_rpt", "pathway_ids": ["R-HSA-141444", "R-HSA-5663220", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-9648025", "R-HSA-68877", "R-HSA-156711"], "pathways": ["R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-156711:r:Polo-like kinase mediated events"], "type": "Domain"}, "IPR019514": {"description": "Syndetin, C-terminal", "go_ids": [], "go_terms": [], "name": "Syndetin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019515": {"description": "Vacuolar protein sorting-associated protein 54, N-terminal", "go_ids": [], "go_terms": [], "name": "VPS54_N", "pathway_ids": ["R-DME-6811440", "R-HSA-6811440", "R-RNO-6811440", "R-MMU-6811440"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR019516": {"description": "Glomulin/ALF4", "go_ids": [], "go_terms": [], "name": "Glomulin/ALF4", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR019517": {"description": "Integrin binding protein, ICAP-1", "go_ids": [], "go_terms": [], "name": "Integrin-bd_ICAP-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019518": {"description": "DNA endonuclease Ctp1, N-terminal", "go_ids": [], "go_terms": [], "name": "CtIP_N", "pathway_ids": ["R-DRE-5693607", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5685939", "R-MMU-6804756", "R-DRE-5685939", "R-MMU-5693616", "R-HSA-8953750", "R-MMU-5685938", "R-MMU-69473", "R-DRE-5693568", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-5685938", "R-HSA-912446", "R-MMU-5685939", "R-RNO-6804756", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-RNO-5693579", "R-HSA-69473", "R-RNO-5693607", "R-MMU-5685942", "R-DRE-5685942", "R-HSA-9709603", "R-HSA-5685939", "R-RNO-69473", "R-RNO-5685942", "R-HSA-6804756", "R-DRE-69473", "R-HSA-9704331", "R-RNO-5693568", "R-DRE-5693616", "R-RNO-5693616", "R-HSA-5693554", "R-HSA-5693579", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR019519": {"description": "Elongator complex protein 5", "go_ids": ["GO:0033588", "GO:0002098"], "go_terms": ["GO:0033588:elongator holoenzyme complex:C", "GO:0002098:tRNA wobble uridine modification:P"], "name": "Elp5", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR019520": {"description": "Small ribosomal subunit protein mS23, metazoa", "go_ids": ["GO:0003735", "GO:0005739"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005739:mitochondrion:C"], "name": "Ribosomal_mS23_met", "pathway_ids": ["R-CEL-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-CEL-9937383", "R-MMU-9937383", "R-HSA-5419276", "R-HSA-5368286", "R-CEL-5389840", "R-MMU-5419276"], "pathways": ["R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR019522": {"description": "Phosphoinositide 3-kinase regulatory subunit 5/6", "go_ids": ["GO:0005944", "GO:0046935"], "go_terms": ["GO:0005944:phosphatidylinositol 3-kinase complex, class IB:C", "GO:0046935:1-phosphatidylinositol-3-kinase regulator activity:F"], "name": "PIK3R5/6", "pathway_ids": ["R-DDI-114604", "R-MMU-6811558", "R-MMU-114604", "R-DDI-1660499", "R-MMU-1257604", "R-HSA-2219530", "R-HSA-1660499", "R-MMU-1660499", "R-DDI-392451", "R-HSA-6811558", "R-MMU-389357", "R-MMU-392451", "R-MMU-9927354", "R-HSA-389357", "R-MMU-9027276", "R-HSA-1257604", "R-HSA-9027276", "R-HSA-392451", "R-HSA-114604", "R-HSA-9927354"], "pathways": ["R-DDI-114604:r:GPVI-mediated activation cascade", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-HSA-9927354:r:Co-stimulation by ICOS"], "type": "Family"}, "IPR019523": {"description": "Protein phosphatase 1, regulatory subunit 15A/B, C-terminal", "go_ids": [], "go_terms": [], "name": "Prot_Pase1_reg-su15A/B_C", "pathway_ids": ["R-HSA-9648895", "R-HSA-2173788"], "pathways": ["R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling"], "type": "Domain"}, "IPR019524": {"description": "Beta-soilenoid domain, diatom-type", "go_ids": [], "go_terms": [], "name": "B-solenoid_diatom-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019525": {"description": "Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain", "go_ids": [], "go_terms": [], "name": "Nrf1_NLS/DNA-bd_dimer", "pathway_ids": ["R-HSA-9841251", "R-HSA-1989781", "R-HSA-2151201"], "pathways": ["R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis"], "type": "Domain"}, "IPR019527": {"description": "RZZ complex, subunit KNTC1/ROD, C-terminal", "go_ids": [], "go_terms": [], "name": "RZZ-complex_KNTC1/ROD_C", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-5663220", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR019528": {"description": "Pericentrin/AKAP-450 centrosomal targeting domain", "go_ids": [], "go_terms": [], "name": "PACT_domain", "pathway_ids": ["R-HSA-5576890", "R-MMU-5576890", "R-HSA-9646399", "R-MMU-380259", "R-HSA-6802952", "R-HSA-380284", "R-MMU-380270", "R-HSA-380270", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942", "R-HSA-380320", "R-MMU-9646399", "R-HSA-5576893", "R-MMU-5576893", "R-HSA-9613829", "R-MMU-8854518", "R-HSA-9615710", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259"], "pathways": ["R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-9646399:r:Aggrephagy", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9646399:r:Aggrephagy", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-9615710:r:Late endosomal microautophagy", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR019529": {"description": "SNARE-complex protein Syntaxin-18, N-terminal", "go_ids": [], "go_terms": [], "name": "Syntaxin-18_N", "pathway_ids": ["R-HSA-6811434", "R-RNO-6811434", "R-SCE-6811434", "R-DRE-6811434", "R-MMU-6811434"], "pathways": ["R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR019530": {"description": "Intra-flagellar transport protein 57", "go_ids": [], "go_terms": [], "name": "Intra-flagellar_transport_57", "pathway_ids": ["R-HSA-5610787", "R-DME-5610787", "R-DRE-5610787", "R-HSA-5620924", "R-CEL-5620924", "R-MMU-5610787", "R-MMU-5620924"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-5610787:r:Hedgehog 'off' state", "R-DRE-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR019531": {"description": "Peroxisomal membrane protein 4", "go_ids": [], "go_terms": [], "name": "Pmp4", "pathway_ids": ["R-HSA-9603798", "R-MMU-9603798", "R-RNO-9603798"], "pathways": ["R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import"], "type": "Family"}, "IPR019532": {"description": "Nuclear RNA-splicing-associated protein, SR-25", "go_ids": [], "go_terms": [], "name": "Nucl_RNA-splicing_assoc_SR-25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019533": {"description": "Peptidase S26", "go_ids": ["GO:0004252", "GO:0051604"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0051604:protein maturation:P"], "name": "Peptidase_S26", "pathway_ids": ["R-HSA-1799339", "R-HSA-9918432", "R-HSA-9760173", "R-CFA-422085", "R-HSA-422085", "R-RNO-9768727", "R-MMU-422085", "R-BTA-422085", "R-CFA-9768727", "R-HSA-9828806", "R-BTA-9768727", "R-RNO-422085", "R-HSA-381771", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-400511"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9760173:r:Secretion of toxins", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Domain"}, "IPR019534": {"description": "Protein of unknown function DUF2452", "go_ids": [], "go_terms": [], "name": "DUF2452", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019535": {"description": "Little elongation complex subunit 2 , C-terminal", "go_ids": ["GO:0008023"], "go_terms": ["GO:0008023:transcription elongation factor complex:C"], "name": "ICE2_C", "pathway_ids": ["R-MMU-6807505", "R-HSA-6807505"], "pathways": ["R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR019536": {"description": "Harmonin-binding protein USHBP1, PDZ-binding domain", "go_ids": [], "go_terms": [], "name": "USHBP1_PDZ-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019537": {"description": "Transmembrane protein 65", "go_ids": [], "go_terms": [], "name": "TMEM65", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019538": {"description": "26S proteasome non-ATPase regulatory subunit 5", "go_ids": ["GO:0043248"], "go_terms": ["GO:0043248:proteasome assembly:P"], "name": "PSMD5", "pathway_ids": ["R-SPO-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-DME-9907900"], "pathways": ["R-SPO-9907900:r:Proteasome assembly", "R-HSA-9907900:r:Proteasome assembly", "R-MMU-9907900:r:Proteasome assembly", "R-DME-9907900:r:Proteasome assembly"], "type": "Family"}, "IPR019539": {"description": "Galactokinase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GalKase_N", "pathway_ids": ["PWY-6527", "PWY-3821", "PWY-6317", "R-HSA-70370", "R-HSA-5609976", "R-MMU-70370", "R-CFA-70370", "R-BTA-70370"], "pathways": ["PWY-6527:t:stachyose degradation", "PWY-3821:t:D-galactose detoxification", "PWY-6317:t:D-galactose degradation I (Leloir pathway)", "R-HSA-70370:r:Galactose catabolism", "R-HSA-5609976:r:Defective GALK1 causes GALCT2", "R-MMU-70370:r:Galactose catabolism", "R-CFA-70370:r:Galactose catabolism", "R-BTA-70370:r:Galactose catabolism"], "type": "Domain"}, "IPR019540": {"description": "Phosphatidylinositol-glycan biosynthesis class S protein", "go_ids": ["GO:0042765", "GO:0016255"], "go_terms": ["GO:0042765:GPI-anchor transamidase complex:C", "GO:0016255:attachment of GPI anchor to protein:P"], "name": "PtdIno-glycan_biosynth_class_S", "pathway_ids": ["R-MMU-162791", "R-HSA-162791", "R-RNO-162791"], "pathways": ["R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-HSA-162791:r:Attachment of GPI anchor to uPAR", "R-RNO-162791:r:Attachment of GPI anchor to uPAR"], "type": "Family"}, "IPR019541": {"description": "Trappin protein transglutaminase-binding repeat", "go_ids": [], "go_terms": [], "name": "Trappin_transglut-bd_rpt", "pathway_ids": ["R-SSC-6803157", "R-HSA-6803157", "R-SSC-6809371", "R-HSA-6809371"], "pathways": ["R-SSC-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-SSC-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Repeat"}, "IPR019542": {"description": "Enhancer of polycomb-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Enhancer_polycomb-like_N", "pathway_ids": ["R-MMU-3214847", "R-HSA-6804758", "R-MMU-8953750", "R-HSA-114608", "R-SPO-6804758", "R-MMU-6804758", "R-DME-114608", "R-DME-6804758", "R-HSA-3214847", "R-SCE-114608", "R-DRE-3214847", "R-HSA-8953750", "R-SPO-114608", "R-SCE-6804758", "R-MMU-114608"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-114608:r:Platelet degranulation", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-114608:r:Platelet degranulation", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-3214847:r:HATs acetylate histones", "R-SCE-114608:r:Platelet degranulation", "R-DRE-3214847:r:HATs acetylate histones", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-SPO-114608:r:Platelet degranulation", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR019543": {"description": "Beta-amyloid precursor protein C-terminal", "go_ids": [], "go_terms": [], "name": "APP_amyloid_C", "pathway_ids": ["R-MMU-416476", "R-SSC-432720", "R-DME-381426", "R-HSA-879415", "R-MMU-9837999", "R-MMU-444473", "R-DME-8957275", "R-HSA-3000178", "R-HSA-977225", "R-HSA-933542", "R-RNO-444473", "R-SSC-114608", "R-HSA-8862803", "R-CEL-3000178", "R-HSA-416476", "R-MMU-933542", "R-RNO-9609523", "R-DME-3000178", "R-MMU-418594", "R-MMU-8957275", "R-RNO-114608", "R-RNO-418594", "R-CEL-416476", "R-HSA-114608", "R-CEL-9609523", "R-MMU-445989", "R-MMU-3000178", "R-RNO-8957275", "R-SSC-933542", "R-MMU-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-444473", "R-DME-9609523", "R-HSA-9837999", "R-MMU-432720", "R-HSA-9609523", "R-MMU-9609523", "R-SSC-445989", "R-RNO-416476", "R-RNO-3000178", "R-HSA-381426", "R-SSC-3000178", "R-HSA-844456", "R-SSC-381426", "R-SSC-8957275", "R-RNO-432720", "R-HSA-432720", "R-DME-114608", "R-DME-9837999", "R-HSA-9660826", "R-MMU-879415", "R-HSA-445989", "R-SSC-9609523", "R-CEL-114608", "R-RNO-9837999", "R-SSC-879415", "R-RNO-381426", "R-HSA-418594", "R-RNO-879415", "R-RNO-445989", "R-SSC-9837999", "R-HSA-8957275", "R-RNO-933542", "R-MMU-114608"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-SSC-114608:r:Platelet degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-3000178:r:ECM proteoglycans", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-416476:r:G alpha (q) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-HSA-844456:r:The NLRP3 inflammasome", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-114608:r:Platelet degranulation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-114608:r:Platelet degranulation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR019544": {"description": "Tetratricopeptide, SHNi-TPR domain", "go_ids": [], "go_terms": [], "name": "Tetratricopeptide_SHNi-TPR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019545": {"description": "DM13 domain", "go_ids": [], "go_terms": [], "name": "DM13_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019546": {"description": "Twin-arginine translocation pathway, signal sequence, bacterial/archaeal", "go_ids": [], "go_terms": [], "name": "TAT_signal_bac_arc", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR019547": {"description": "Lipid desaturase domain", "go_ids": [], "go_terms": [], "name": "Lipid_desat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019548": {"description": "CTF transcription factor/nuclear factor 1, N-terminal", "go_ids": [], "go_terms": [], "name": "CTF/NFI_DNA-bd_N", "pathway_ids": ["R-HSA-73980", "R-HSA-749476"], "pathways": ["R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation"], "type": "Domain"}, "IPR019549": {"description": "Homeobox engrailed, C-terminal", "go_ids": [], "go_terms": [], "name": "Homeobox-engrailed_C-terminal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019552": {"description": "Histidine-rich calcium-binding", "go_ids": [], "go_terms": [], "name": "Hist_rich_Ca-bd", "pathway_ids": ["R-HSA-8957275", "R-HSA-381426"], "pathways": ["R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Repeat"}, "IPR019553": {"description": "Spider toxin CSTX, Knottin scaffold", "go_ids": ["GO:0090729"], "go_terms": ["GO:0090729:toxin activity:F"], "name": "Spider_toxin_CSTX_knottin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019554": {"description": "Soluble ligand binding domain", "go_ids": [], "go_terms": [], "name": "Soluble_ligand-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019557": {"description": "Aminotransferase-like, plant mobile domain", "go_ids": [], "go_terms": [], "name": "AminoTfrase-like_pln_mobile", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019559": {"description": "Cullin, neddylation domain", "go_ids": [], "go_terms": [], "name": "Cullin_neddylation_domain", "pathway_ids": ["R-HSA-9020702", "R-HSA-9013418", "R-HSA-9604323", "R-RNO-9013422", "R-CEL-5632684", "R-HSA-8951664", "R-HSA-9010553", "R-CEL-195253", "R-MMU-9020702", "R-DDI-6782210", "R-MMU-9706019", "R-HSA-69231", "R-RNO-8863795", "R-MMU-110314", "R-CEL-110314", "R-HSA-5684264", "R-CEL-1234176", "R-HSA-8863795", "R-DDI-9929491", "R-SPO-917937", "R-XTR-9013418", "R-DME-5676590", "R-HSA-8854050", "R-MMU-5696394", "R-CEL-5696394", "R-HSA-5610783", "R-HSA-2122947", "R-CEL-69231", "R-HSA-9708530", "R-HSA-1234176", "R-RNO-4641258", "R-CEL-917937", "R-HSA-5607761", "R-HSA-9929491", "R-HSA-1170546", "R-MMU-174113", "R-DME-209461", "R-XTR-9929491", "R-RNO-9705462", "R-CEL-6782210", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-DDI-5696394", "R-RNO-8951664", "R-SPO-110314", "R-HSA-5696395", "R-HSA-5696394", "R-CEL-5696395", "R-CEL-6782135", "R-DME-69601", "R-SPO-8951664", "R-HSA-2644606", "R-MMU-9013418", "R-DDI-9013418", "R-DDI-187577", "R-HSA-9833109", "R-SCE-917937", "R-RNO-5632684", "R-HSA-5610785", "R-HSA-68949", "R-DME-983168", "R-HSA-6781827", "R-DME-202424", "R-DME-187577", "R-DDI-5696395", "R-MMU-187577", "R-SCE-8854050", "R-MMU-68949", "R-DME-2565942", "R-CEL-983168", "R-DDI-9013422", "R-CEL-8854050", "R-MMU-917937", "R-MMU-6781823", "R-DDI-9706019", "R-DDI-69601", "R-HSA-6782210", "R-MMU-9762114", "R-HSA-9762114", "R-DME-917937", "R-MMU-195253", "R-MMU-5696400", "R-MMU-202424", "R-RNO-9013418", "R-HSA-195253", "R-HSA-5610780", "R-HSA-381038", "R-DME-209360", "R-CEL-9755511", "R-DDI-917937", "R-DDI-69231", "R-RNO-9755511", "R-MMU-1169091", "R-XTR-8951664", "R-MMU-5607761", "R-DME-8854050", "R-MMU-5676590", "R-HSA-8939902", "R-HSA-9725371", "R-MMU-8939902", "R-CEL-2565942", "R-SPO-6782210", "R-HSA-5696400", "R-DME-9020702", "R-CEL-9762114", "R-CEL-8951664", "R-SPO-8854050", "R-DDI-8854050", "R-MMU-5632684", "R-HSA-9013422", "R-MMU-5607764", "R-DME-8951664", "R-HSA-9932298", "R-DME-69231", "R-CEL-187577", "R-HSA-5676590", "R-MMU-2565942", "R-DDI-8951664", "R-HSA-6781823", "R-DDI-5632684", "R-MMU-8951664", "R-MMU-5696395", "R-SPO-5696395", "R-DME-174113", "R-DME-8939902", "R-MMU-9013422", "R-MMU-9929491", "R-HSA-174113", "R-MMU-9929356", "R-MMU-5684264", "R-DME-9762114", "R-CEL-4641258", "R-DDI-5658442", "R-DDI-6781823", "R-HSA-9755511", "R-XTR-4641258", "R-HSA-4641258", "R-CEL-9929491", "R-MMU-9705462", "R-MMU-9708530", "R-CEL-6781823", "R-HSA-180585", "R-HSA-1169091", "R-HSA-5658442", "R-HSA-2644607", "R-MMU-2871837", "R-DDI-68949", "R-DME-5610785", "R-MMU-6782210", "R-DME-5607764", "R-RNO-983168", "R-DME-2871837", "R-HSA-110314", "R-MMU-69231", "R-DDI-6782135", "R-MMU-8863795", "R-MMU-5610780", "R-HSA-187577", "R-DME-1169091", "R-CEL-8863795", "R-XTR-5632684", "R-DDI-9755511", "R-MMU-6782135", "R-DME-5610780", "R-XTR-9013422", "R-CEL-8939902", "R-MMU-9755511", "R-MMU-9954709", "R-DME-195253", "R-MMU-69601", "R-HSA-2565942", "R-HSA-2871837", "R-MMU-5610785", "R-HSA-9954709", "R-DME-5607761", "R-MMU-8854050", "R-SPO-983168", "R-MMU-5658442", "R-SCE-983168", "R-HSA-5607764", "R-DME-68949", "R-MMU-1170546", "R-CEL-9954709", "R-RNO-9929491", "R-HSA-9706019", "R-HSA-2894862", "R-RNO-9706019", "R-HSA-69601", "R-HSA-9679191", "R-HSA-983168", "R-HSA-6782135", "R-HSA-5632684", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-XTR-983168", "R-SPO-5696400", "R-XTR-9755511", "R-RNO-5658442", "R-HSA-917937", "R-HSA-9705462", "R-MMU-983168", "R-SPO-6782135", "R-HSA-202424"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-69231:r:Cyclin D associated events in G1", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-917937:r:Iron uptake and transport", "R-XTR-9013418:r:RHOBTB2 GTPase cycle", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-CEL-69231:r:Cyclin D associated events in G1", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1170546:r:Prolactin receptor signaling", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-XTR-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-8951664:r:Neddylation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-SCE-917937:r:Iron uptake and transport", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the 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"R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-917937:r:Iron uptake and transport", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-XTR-8951664:r:Neddylation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-9020702:r:Interleukin-1 signaling", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8951664:r:Neddylation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-69231:r:Cyclin D associated events in G1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5632684:r:Hedgehog 'on' state", "R-MMU-8951664:r:Neddylation", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", 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"R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-XTR-5632684:r:Hedgehog 'on' state", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-XTR-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-SCE-983168:r:Antigen processing: Ubiquitination & 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"R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-XTR-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-202424:r:Downstream TCR signaling"], "type": "Domain"}, "IPR019560": {"description": "Mitochondrial 18kDa protein", "go_ids": [], "go_terms": [], "name": "Mitochondrial_18_kDa_protein_", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019561": {"description": "Translocon Sec61/SecY, plug domain", "go_ids": [], "go_terms": [], "name": "Translocon_Sec61/SecY_plug_dom", "pathway_ids": ["R-HSA-1799339", "R-HSA-1236974"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-1236974:r:ER-Phagosome pathway"], "type": "Domain"}, "IPR019562": {"description": "Micronemal adhesive repeat, sialic-acid binding", "go_ids": [], "go_terms": [], "name": "Micronemal-adhesive-rpt_sia-bd", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR019563": {"description": "Glycosyl-hydrolase 97, catalytic domain", "go_ids": [], "go_terms": [], "name": "GH97_catalytic", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019564": {"description": "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain", "go_ids": ["GO:0001401"], "go_terms": ["GO:0001401:SAM complex:C"], "name": "Sam37/metaxin_N", "pathway_ids": ["R-MMU-9013404", "R-SSC-9013404", "R-HSA-1268020", "R-HSA-8949613", "R-HSA-9013404"], "pathways": ["R-MMU-9013404:r:RAC2 GTPase cycle", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-8949613:r:Cristae formation", "R-HSA-9013404:r:RAC2 GTPase cycle"], "type": "Domain"}, "IPR019566": {"description": "Myelin protein P0, C-terminal", "go_ids": [], "go_terms": [], "name": "MYP0_C", "pathway_ids": ["R-HSA-9619665"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "type": "Domain"}, "IPR019568": {"description": "Rapsyn, myristoylation/linker region, N-terminal", "go_ids": ["GO:0007268", "GO:0033130", "GO:0043495"], "go_terms": ["GO:0007268:chemical synaptic transmission:P", "GO:0033130:acetylcholine receptor binding:F", "GO:0043495:protein-membrane adaptor activity:F"], "name": "Rapsyn_myristoylation/link_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019570": {"description": "Connexin, cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "Connexin_CCC", "pathway_ids": ["R-RNO-190840", "R-HSA-9013409", "R-DRE-196025", "R-MMU-190872", "R-BTA-196025", "R-HSA-9725554", "R-HSA-190861", "R-GGA-190861", "R-HSA-190840", "R-HSA-190873", "R-HSA-191650", "R-BTA-9013406", 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responses by IFN-stimulated genes", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-SCE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-SPO-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-SCE-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "type": "Domain"}, "IPR019574": {"description": "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd", "pathway_ids": ["R-DDI-9837999", "R-RNO-611105", "R-HSA-611105", "R-MMU-9837999", "R-MMU-6799198", "R-BTA-9837999", "R-HSA-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DME-9837999", "R-MMU-611105", "R-HSA-9837999", "R-RNO-9837999", "R-BTA-6799198", "R-DDI-6799198", "R-DME-611105", "R-BTA-611105"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6799198:r:Complex I biogenesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR019575": {"description": "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain", "go_ids": ["GO:0051539"], "go_terms": ["GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Nuop51_4Fe4S-bd", "pathway_ids": ["R-DDI-9837999", "R-HSA-611105", "R-MMU-9837999", "R-SPO-9837999", "R-HSA-6799198", "R-MMU-6799198", "R-MMU-611105", "R-HSA-9837999", "R-DDI-6799198"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-6799198:r:Complex I biogenesis"], "type": "Domain"}, "IPR019576": {"description": "Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal", "go_ids": [], "go_terms": [], "name": "Pyridoxamine_oxidase_dimer_C", "pathway_ids": ["PWY-7204", "PWY-7282", "R-DDI-964975", "R-BTA-964975", "R-RNO-964975", "R-SCE-964975", "R-HSA-964975", "R-SPO-964975", "R-MMU-964975", "R-CEL-964975"], "pathways": ["PWY-7204:t:pyridoxal 5'-phosphate salvage II (plants)", "PWY-7282:t:4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-BTA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-SCE-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-SPO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate"], "type": "Domain"}, "IPR019577": {"description": "SPARC/Testican, calcium-binding domain", "go_ids": ["GO:0005509"], "go_terms": ["GO:0005509:calcium ion binding:F"], "name": "SPARC/Testican_Ca-bd-dom", "pathway_ids": ["R-CEL-1592389", "R-HSA-3000497", "R-MMU-1592389", "R-RNO-3000497", "R-HSA-3000178", "R-HSA-1251985", "R-SSC-114608", "R-CEL-114608", "R-MMU-3000497", "R-HSA-1592389", "R-MMU-8957275", "R-RNO-114608", "R-BTA-3000497", "R-RNO-381426", "R-HSA-114608", "R-BTA-114608", "R-RNO-8957275", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-SSC-3000497", "R-HSA-8957275", "R-HSA-381426", "R-MMU-114608"], "pathways": ["R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-BTA-3000497:r:Scavenging by Class H Receptors", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000497:r:Scavenging by Class H Receptors", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR019579": {"description": "Protein FAM161A/B", "go_ids": [], "go_terms": [], "name": "FAM161A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019580": {"description": "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding", "go_ids": ["GO:0017070"], "go_terms": ["GO:0017070:U6 snRNA binding:F"], "name": "Prp8_U6-snRNA-bd", "pathway_ids": ["R-HSA-72163", "R-CEL-72165", "R-MMU-72165", "R-MMU-72163", "R-HSA-72165", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR019581": {"description": "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding", "go_ids": ["GO:0030623"], "go_terms": ["GO:0030623:U5 snRNA binding:F"], "name": "Prp8_U5-snRNA-bd", "pathway_ids": ["R-HSA-72163", "R-CEL-72165", "R-MMU-72165", "R-MMU-72163", "R-HSA-72165", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR019582": {"description": "RNA recognition motif, spliceosomal PrP8", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "RRM_spliceosomal_PrP8", "pathway_ids": ["R-HSA-72163", "R-CEL-72165", "R-MMU-72165", "R-MMU-72163", "R-HSA-72165", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR019583": {"description": "Disks large homolog 1-4, PDZ-associated domain", "go_ids": [], "go_terms": [], "name": "DLG1-4_PDZ_assoc", "pathway_ids": ["R-HSA-5625900", "R-MMU-451308", "R-DRE-438066", "R-HSA-8849932", "R-HSA-442982", "R-HSA-6794361", "R-CFA-451308", "R-CFA-8849932", "R-CFA-5673001", "R-RNO-451308", "R-RNO-5673001", "R-HSA-447038", "R-HSA-9617324", "R-MMU-5673001", "R-RNO-5682910", "R-HSA-399719", "R-HSA-451308", "R-XTR-8849932", "R-MMU-8849932", "R-MMU-438066", "R-MMU-6794361", "R-MMU-5625900", "R-RNO-399719", "R-RNO-438066", "R-HSA-1236394", "R-HSA-5673001", "R-RNO-5625900", "R-DRE-8849932", "R-HSA-438066", "R-HSA-9620244", "R-CFA-399719", "R-XTR-438066", "R-MMU-5682910", "R-CFA-438066", "R-HSA-5682910", "R-RNO-6794361", "R-RNO-8849932", "R-HSA-9609736", "R-MMU-399719"], "pathways": ["R-HSA-5625900:r:RHO GTPases activate CIT", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-HSA-6794361:r:Neurexins and neuroligins", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-447038:r:NrCAM interactions", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-5682910:r:LGI-ADAM interactions", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-6794361:r:Neurexins and neuroligins", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9620244:r:Long-term potentiation", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5682910:r:LGI-ADAM interactions", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5682910:r:LGI-ADAM interactions", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-399719:r:Trafficking of AMPA receptors"], "type": "Domain"}, "IPR019585": {"description": "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1", "go_ids": [], "go_terms": [], "name": "Rpn7/CSN1", "pathway_ids": ["R-RNO-6781823", "R-MMU-450408", "R-HSA-174178", "R-HSA-9020702", "R-HSA-9604323", "R-RNO-9013422", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-8951664", "R-HSA-5689880", "R-HSA-9010553", "R-MMU-174154", "R-MMU-69017", "R-HSA-75815", "R-CEL-195253", "R-CEL-8941858", "R-MMU-9020702", "R-DME-5658442", "R-MMU-8948751", "R-DME-8948751", "R-MMU-69481", "R-DME-5696394", "R-SPO-5689880", "R-DDI-8856825", "R-MMU-5689880", "R-MMU-75815", "R-CEL-1234176", "R-DDI-9929491", "R-MMU-5668541", "R-DME-2467813", "R-HSA-8854050", "R-DME-5676590", "R-MMU-5696394", "R-HSA-450408", "R-CEL-5696394", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-HSA-1234176", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-DDI-174084", "R-MMU-68867", "R-DME-4641257", "R-DME-432524", "R-MMU-9932298", "R-DME-209461", "R-MMU-1234176", "R-RNO-5696394", "R-MMU-4641258", "R-DME-75815", "R-DDI-4641258", "R-DDI-5696394", "R-RNO-8951664", "R-HSA-5696394", "R-HSA-180534", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-CEL-8948751", "R-MMU-5687128", "R-CEL-8856825", "R-MMU-9766229", "R-DME-5358346", "R-HSA-174154", "R-DDI-187577", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-DDI-382556", "R-MMU-187577", "R-HSA-2467813", "R-DME-202424", "R-DME-187577", "R-MMU-8852276", "R-SCE-6798695", "R-MMU-68949", "R-CEL-9907900", "R-HSA-9824272", "R-MMU-174178", "R-CEL-983168", "R-DDI-9013422", "R-MMU-349425", "R-MMU-8939236", "R-CEL-8854050", "R-HSA-9907900", "R-MMU-6781823", "R-DME-350562", "R-DME-174084", "R-DME-9907900", "R-DDI-5689603", "R-CEL-75815", "R-DDI-69601", "R-DDI-2467813", "R-DME-9929491", "R-MMU-9762114", "R-HSA-9762114", "R-DDI-5689880", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-MMU-382556", "R-HSA-5610780", "R-DME-209360", "R-DDI-5687128", "R-CEL-9755511", "R-DME-6798695", "R-DDI-9907900", "R-SCE-1236978", "R-DME-8939236", 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"R-DDI-8948751", "R-HSA-5678895", "R-DDI-6781823", "R-HSA-9755511", "R-HSA-4641258", "R-CEL-9929491", "R-SPO-5689603", "R-DME-9755511", "R-DME-1236978", "R-CEL-6781823", "R-HSA-180585", "R-SPO-1236978", "R-HSA-1169091", "R-CEL-69017", "R-HSA-4608870", "R-HSA-5658442", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-DME-450408", "R-DME-8941858", "R-SPO-6798695", "R-HSA-187577", "R-MMU-5610780", "R-DME-9954709", "R-DME-1169091", "R-DDI-9755511", "R-MMU-8856825", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-DDI-75815", "R-MMU-350562", "R-MMU-69601", "R-DME-195253", "R-HSA-2871837", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-DME-5607761", "R-MMU-5658442", "R-MMU-5689603", "R-DME-5689603", 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"R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-68949:r:Orc1 removal from chromatin", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Family"}, "IPR019587": {"description": "Polyketide cyclase/dehydrase", "go_ids": [], "go_terms": [], "name": "Polyketide_cyclase/dehydratase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019588": {"description": "Metabotropic glutamate receptor, Homer-binding domain", "go_ids": [], "go_terms": [], "name": "Metabotropic_Glu_rcpt_Homer-bd", "pathway_ids": ["R-MMU-416476", "R-HSA-9717207", "R-MMU-420499", "R-MMU-6794361", "R-RNO-420499", "R-HSA-420499", "R-RNO-6794361", "R-HSA-416476", "R-RNO-416476", "R-HSA-6794361"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-6794361:r:Neurexins and neuroligins", "R-RNO-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-6794361:r:Neurexins and neuroligins", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-6794361:r:Neurexins and neuroligins"], "type": "Domain"}, "IPR019590": {"description": "Disks large homologue 1, N-terminal PEST domain", "go_ids": [], "go_terms": [], "name": "DLG1_PEST_dom", "pathway_ids": ["R-HSA-5625900", "R-MMU-451308", "R-DRE-438066", "R-HSA-8849932", "R-HSA-442982", "R-HSA-6794361", "R-CFA-451308", "R-CFA-8849932", "R-CFA-5673001", "R-RNO-451308", "R-RNO-5673001", "R-HSA-447038", "R-HSA-9617324", "R-MMU-5673001", "R-RNO-5682910", "R-HSA-399719", "R-HSA-451308", "R-XTR-8849932", "R-MMU-8849932", "R-MMU-438066", "R-MMU-6794361", "R-MMU-5625900", "R-RNO-399719", "R-RNO-438066", "R-HSA-1236394", "R-HSA-5673001", "R-RNO-5625900", "R-DRE-8849932", "R-HSA-438066", "R-HSA-9620244", "R-CFA-399719", "R-XTR-438066", "R-MMU-5682910", "R-CFA-438066", "R-HSA-5682910", "R-RNO-6794361", "R-RNO-8849932", "R-HSA-9609736", "R-MMU-399719"], "pathways": ["R-HSA-5625900:r:RHO GTPases activate CIT", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-HSA-6794361:r:Neurexins and neuroligins", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-447038:r:NrCAM interactions", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-5682910:r:LGI-ADAM interactions", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-6794361:r:Neurexins and neuroligins", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9620244:r:Long-term potentiation", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5682910:r:LGI-ADAM interactions", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5682910:r:LGI-ADAM interactions", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-399719:r:Trafficking of AMPA receptors"], "type": "Domain"}, "IPR019591": {"description": "Mrp/NBP35 ATP-binding protein", "go_ids": ["GO:0016226", "GO:0051536", "GO:0140663", "GO:0005524"], "go_terms": ["GO:0016226:iron-sulfur cluster assembly:P", "GO:0051536:iron-sulfur cluster binding:F", "GO:0140663:ATP-dependent FeS chaperone activity:F", "GO:0005524:ATP binding:F"], "name": "Mrp/NBP35_ATP-bd", "pathway_ids": ["R-DME-6799198", "R-MMU-6799198", "R-HSA-2564830", "R-DDI-6799198", "R-HSA-6799198"], "pathways": ["R-DME-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-DDI-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR019592": {"description": "Protein of unknown function DUF2469", "go_ids": [], "go_terms": [], "name": "DUF2469", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019593": {"description": "Spore coat protein Z/Y", "go_ids": [], "go_terms": [], "name": "Spore_coat_protein_Z/Y", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019594": {"description": "Ionotropic glutamate receptor, L-glutamate and glycine-binding domain", "go_ids": ["GO:0015276", "GO:0016020"], "go_terms": ["GO:0015276:ligand-gated monoatomic ion channel activity:F", "GO:0016020:membrane:C"], "name": "Glu/Gly-bd", "pathway_ids": ["R-MMU-204005", "R-DME-399710", "R-RNO-451307", "R-MMU-451308", "R-MMU-9609736", "R-MMU-5694530", "R-CEL-438066", "R-HSA-442982", "R-MMU-399710", "R-HSA-5694530", "R-HSA-3928662", "R-CEL-451307", "R-CFA-8849932", "R-CEL-451308", "R-CEL-204005", "R-CFA-5673001", "R-RNO-5673001", "R-MMU-5673001", "R-DME-438066", "R-CEL-5694530", "R-HSA-451308", "R-MMU-8849932", "R-MMU-438066", "R-DME-3928662", "R-RNO-399710", "R-RNO-438066", "R-HSA-5673001", "R-CFA-3928662", "R-HSA-204005", "R-RNO-500657", "R-HSA-9620244", "R-CEL-399710", "R-RNO-8849932", "R-HSA-9609736", "R-CEL-8849932", "R-DME-9609736", "R-CFA-9609736", "R-DME-416993", "R-HSA-451307", "R-HSA-8849932", "R-HSA-399710", "R-CEL-500657", "R-HSA-6794361", "R-HSA-500657", "R-RNO-3928662", "R-RNO-451308", "R-HSA-9617324", "R-MMU-416993", "R-HSA-416993", "R-RNO-5694530", "R-HSA-399719", "R-MMU-500657", "R-RNO-399719", "R-HSA-9032500", "R-RNO-204005", "R-RNO-9609736", "R-DME-8849932", "R-HSA-438066", 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"R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-5694530:r:Cargo concentration in the ER", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-RNO-399710:r:Activation of AMPA receptors", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-500657:r:Presynaptic function of Kainate receptors", "R-HSA-9620244:r:Long-term potentiation", "R-CEL-399710:r:Activation of AMPA receptors", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DME-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-451307:r:Activation of Na-permeable kainate receptors", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-399710:r:Activation of AMPA receptors", "R-CEL-500657:r:Presynaptic function of Kainate receptors", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-451307:r:Activation of Na-permeable kainate receptors", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors"], "type": "Domain"}, "IPR019595": {"description": "Domain of unknown function DUF2470", "go_ids": [], "go_terms": [], "name": 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binding:F", "GO:0016706:2-oxoglutarate-dependent dioxygenase activity:F", "GO:0031418:L-ascorbic acid binding:F"], "name": "Oxoglutarate/Fe-dep_Oase_C", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-HSA-9629569", "R-DME-9629569", "R-MMU-9629569", "R-BTA-9629569", "R-SCE-9629569", "R-SPO-9629569"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins 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"PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-HSA-9629569:r:Protein hydroxylation", "R-DME-9629569:r:Protein hydroxylation", "R-MMU-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-SCE-9629569:r:Protein hydroxylation", "R-SPO-9629569:r:Protein hydroxylation"], "type": "Domain"}, "IPR019602": {"description": "mRNA capping enzyme catalytic subunit, RNA triphosphatase domain, virus", "go_ids": ["GO:0004651", "GO:0004484"], "go_terms": ["GO:0004651:polynucleotide 5'-phosphatase activity:F", "GO:0004484:mRNA guanylyltransferase activity:F"], "name": "MCEL_TPase", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Domain"}, "IPR019603": {"description": "Mitochondrial outer membrane translocase complex, subunit Tom5", "go_ids": [], "go_terms": [], "name": "Tom5", "pathway_ids": ["R-MMU-5205685", "R-HSA-1268020", "R-BTA-5205685", "R-HSA-5205685"], "pathways": ["R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy"], "type": "Family"}, "IPR019604": {"description": "Photosystem P840 reaction-centre, cytochrome c-551", "go_ids": [], "go_terms": [], "name": "Cytochrome-c551", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019605": {"description": "Misato Segment II tubulin-like domain", "go_ids": [], "go_terms": [], "name": "Misato_II_tubulin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019606": {"description": "GerMN domain", "go_ids": [], "go_terms": [], "name": "GerMN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019607": {"description": "Putative zinc-finger domain", "go_ids": [], "go_terms": [], "name": "Putative_zinc-finger_domain", "pathway_ids": ["R-HSA-9930044"], "pathways": ["R-HSA-9930044:r:Nuclear RNA decay"], "type": "Domain"}, "IPR019608": {"description": "Photosystem I P840 reaction centre protein PscD", "go_ids": [], "go_terms": [], "name": "PSI_P840_PscD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019609": {"description": "Variant surface glycoprotein , C-terminal", "go_ids": [], "go_terms": [], "name": "VSG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019610": {"description": "Iron sulphur domain-containing, mitoNEET, N-terminal", "go_ids": ["GO:0043231", "GO:0051537"], "go_terms": ["GO:0043231:intracellular membrane-bounded organelle:C", "GO:0051537:2 iron, 2 sulfur cluster binding:F"], "name": "FeS-contain_mitoNEET_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019612": {"description": "Minor capsid protein, putative", "go_ids": [], "go_terms": [], "name": "Minor_capsid_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019613": {"description": "Protein of unknown function DUF4198", "go_ids": [], "go_terms": [], "name": "DUF4198", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019614": {"description": "S-adenosylmethionine-dependent methyltransferase", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "SAM-dep_methyl-trfase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019615": {"description": "Protein of unknown function DUF2487", "go_ids": [], "go_terms": [], "name": "DUF2487", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019616": {"description": "Ycf54 protein", "go_ids": [], "go_terms": [], "name": "Ycf54", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019617": {"description": "Domain of unknown function DUF2489", "go_ids": [], "go_terms": [], "name": "DUF2489", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019618": {"description": "Spore germination protein GerPA/GerPF", "go_ids": [], "go_terms": [], "name": "Spore_germination_GerPA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019619": {"description": "Protein of unknown function DUF2490", "go_ids": [], "go_terms": [], "name": "DUF2490", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019620": {"description": "Putative metal-binding protein", "go_ids": [], "go_terms": [], "name": "Metal-bd_prot_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019621": {"description": "Protein of unknown function DUF2491", "go_ids": [], "go_terms": [], "name": "DUF2491", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019622": {"description": "Rrn9 domain", "go_ids": [], "go_terms": [], "name": "Rrn9_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019623": {"description": "Protein Rot1", "go_ids": ["GO:0006458", "GO:0005783"], "go_terms": ["GO:0006458:'de novo' protein folding:P", "GO:0005783:endoplasmic reticulum:C"], "name": "Rot1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019624": {"description": "Herpesvirus UL40", "go_ids": [], "go_terms": [], "name": "Herpes_UL40", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019625": {"description": "Biofilm-dependent modulation protein Bdm, putative", "go_ids": [], "go_terms": [], "name": "Biofilm-dep_modulation_Bdm_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019626": {"description": "Stress-induced protein, KGG, repeat", "go_ids": [], "go_terms": [], "name": "Stress-induced_KGG_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR019627": {"description": "YspA, cpYpsA-related SLOG", "go_ids": [], "go_terms": [], "name": "YAcAr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019629": {"description": "Uncharacterised protein family HI1736/YgjV", "go_ids": [], "go_terms": [], "name": "Uncharacterised_HI1736/YgjV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019630": {"description": "Protein of unknown function DUF2496, YbaM-related", "go_ids": [], "go_terms": [], "name": "DUF2496_YbaM-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019631": {"description": "Myticin preproprotein", "go_ids": [], "go_terms": [], "name": "Myticin_preproprotein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019632": {"description": "Domain of unknown function DUF2497", "go_ids": [], "go_terms": [], "name": "DUF2497", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019633": {"description": "Protein of unknown function DUF2498", "go_ids": [], "go_terms": [], "name": "DUF2498", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019634": {"description": "Uncharacterised protein family Ycf49", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf49", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019635": {"description": "Protein of unknown function DUF2500", "go_ids": [], "go_terms": [], "name": "DUF2500", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019637": {"description": "Protein of unknown function DUF2501", "go_ids": [], "go_terms": [], "name": "DUF2501", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019638": {"description": "Protein of unknown function DUF2502", "go_ids": [], "go_terms": [], "name": "DUF2502", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019639": {"description": "Protein of unknown function DUF2505", "go_ids": [], "go_terms": [], "name": "DUF2505", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019642": {"description": "Protein of unknown function DUF2507", "go_ids": [], "go_terms": [], "name": "DUF2507", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019644": {"description": "Protein of unknown function DUF2508", "go_ids": [], "go_terms": [], "name": "DUF2508", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019645": {"description": "Uncharacterised protein family Ycf15", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019646": {"description": "Aminoglycoside-2''-adenylyltransferase", "go_ids": [], "go_terms": [], "name": "Aminoglyc_AdlTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019647": {"description": "PhoP regulatory network protein YrbL", "go_ids": [], "go_terms": [], "name": "PhoP_reg_network_YrbL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019648": {"description": "Protein YebY", "go_ids": [], "go_terms": [], "name": "YebY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019649": {"description": "Protein of unknown function DUF2512", "go_ids": [], "go_terms": [], "name": "DUF2512", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019650": {"description": "Protein of unknown function DUF2513", "go_ids": [], "go_terms": [], "name": "DUF2513", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019651": {"description": "Glutamate dehydrogenase, NAD-specific", "go_ids": [], "go_terms": [], "name": "Glutamate_DH_NAD-spec", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019652": {"description": "Protein of unknown function DUF2509", "go_ids": [], "go_terms": [], "name": "DUF2509", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019653": {"description": "T4 endoribonuclease RegB", "go_ids": [], "go_terms": [], "name": "T4_endoribonuclease_RegB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019654": {"description": "NAD(P)H-quinone oxidoreductase subunit L", "go_ids": ["GO:0016655"], "go_terms": ["GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F"], "name": "NADH-quinone_OxRdatse_su_L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019655": {"description": "Baculovirus occlusion-derived virus envelope, E18", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Baculo_ODV-E18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019656": {"description": "Uncharacterised protein family Ycf34", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019657": {"description": "Late competence development protein ComFB", "go_ids": [], "go_terms": [], "name": "ComFB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019658": {"description": "Protein of unknown function DUF2515", "go_ids": [], "go_terms": [], "name": "DUF2515", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019659": {"description": "Protein of unknown function DUF2514", "go_ids": [], "go_terms": [], "name": "DUF2514", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019660": {"description": "Putative sensory transduction regulator YbjN", "go_ids": [], "go_terms": [], "name": "Put_sensory_transdc_reg_YbjN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019661": {"description": "Replication regulatory protein RepA2", "go_ids": ["GO:0006276"], "go_terms": ["GO:0006276:plasmid maintenance:P"], "name": "RepA2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019662": {"description": "Protein of unknown function DUF2516", "go_ids": [], "go_terms": [], "name": "DUF2516", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019663": {"description": "Uncharacterised protein YbfA", "go_ids": [], "go_terms": [], "name": "YbfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019664": {"description": "Ycf51", "go_ids": [], "go_terms": [], "name": "Ycf51", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019665": {"description": "Putative oxidoreductase/dehydrogenase, Rossmann-like domain", "go_ids": [], "go_terms": [], "name": "OxRdtase/DH_put_Rossmann_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019666": {"description": "Cell division activator CedA", "go_ids": ["GO:0003677", "GO:0051301"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0051301:cell division:P"], "name": "Cell_div_activator_CedA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019667": {"description": "Uncharacterised protein family YbaK", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YbaK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019668": {"description": "Uncharacterised protein family YtzC", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YtzC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019669": {"description": "Uncharacterised bacterial stress protein YodD", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YodD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019670": {"description": "Protein of unkown function DUF2523", "go_ids": [], "go_terms": [], "name": "DUF2523", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019671": {"description": "Protein of unknown function DUF2526", "go_ids": [], "go_terms": [], "name": "DUF2526", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019672": {"description": "Protein of unknown function DUF2627", "go_ids": [], "go_terms": [], "name": "DUF2527", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019673": {"description": "Spore germination protein GerPC", "go_ids": [], "go_terms": [], "name": "Spore_germination_GerPC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019674": {"description": "Lipoprotein LpqN/LpqT-like", "go_ids": [], "go_terms": [], "name": "Lipoprotein_LpqN/LpqT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019675": {"description": "Protein of unknown function DUF2550", "go_ids": [], "go_terms": [], "name": "DUF2550", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019676": {"description": "Domain of unknown function DUF2529", "go_ids": [], "go_terms": [], "name": "DUF2529", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019678": {"description": "Protein of unknown function DUF2555", "go_ids": [], "go_terms": [], "name": "DUF2555", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019679": {"description": "Regulatory phage protein Cox", "go_ids": [], "go_terms": [], "name": "Phage_P2_Cox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019680": {"description": "Mediator complex, subunit Med1", "go_ids": ["GO:0006357", "GO:0016592", "GO:0003712"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Mediator_Med1", "pathway_ids": ["R-HSA-1989781", "R-HSA-2151201", "R-DME-383280", "R-DME-9018519", "R-DME-9707564", "R-HSA-381340", "R-HSA-9707616", "R-HSA-9931509", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-9018519", "R-HSA-383280", "R-MMU-383280", "R-DME-9841922", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-400206", "R-HSA-9833110", "R-MMU-400206", "R-DME-400206", "R-HSA-9018519", "R-HSA-212436", "R-MMU-9707564", "R-HSA-2426168"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-383280:r:Nuclear Receptor transcription pathway", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-212436:r:Generic Transcription Pathway", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR019681": {"description": "Protein of unknown function DUF2530", "go_ids": [], "go_terms": [], "name": "DUF2530", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019682": {"description": "Bacteriophage T7, Gp17.5, holin", "go_ids": ["GO:0044659"], "go_terms": ["GO:0044659:viral release from host cell by cytolysis:P"], "name": "Phage_T7_Gp17.5_holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019683": {"description": "Sporulation inhibitor of replication protein SirA", "go_ids": [], "go_terms": [], "name": "SirA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019684": {"description": "HofP protein", "go_ids": [], "go_terms": [], "name": "HofP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019685": {"description": "Protein of unknown function DUF2534", "go_ids": [], "go_terms": [], "name": "DUF2534", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019686": {"description": "Protein of unknown function DUF2536", "go_ids": [], "go_terms": [], "name": "DUF2536", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019687": {"description": "Protein of unknown function DUF2535", "go_ids": [], "go_terms": [], "name": "DUF2535", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019688": {"description": "Protein of unknown function DUF2533", "go_ids": [], "go_terms": [], "name": "DUF2533", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019689": {"description": "Toxin GhoT/OrtT", "go_ids": [], "go_terms": [], "name": "Toxin_GhoT/OrtT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019690": {"description": "Protein of unknown function DUF2569", "go_ids": [], "go_terms": [], "name": "DUF2569", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019691": {"description": "Protein of unknown function DUF2585", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "DUF2585", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019692": {"description": "Low molecular weight protein antigen 6, PH domain", "go_ids": [], "go_terms": [], "name": "CFP-6_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019693": {"description": "Biofilm formation regulator YbaJ", "go_ids": [], "go_terms": [], "name": "Biofilm_formation_reg_YbaJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019694": {"description": "HP1 ORF23 tail sheath protein, N-terminal", "go_ids": [], "go_terms": [], "name": "HP1_ORF23_tail_sheath_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019695": {"description": "Bacterial proteasome activator", "go_ids": ["GO:0061136"], "go_terms": ["GO:0061136:regulation of proteasomal protein catabolic process:P"], "name": "Proteasome_act", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019697": {"description": "Bacteriophage HP1, Orf28", "go_ids": [], "go_terms": [], "name": "Phage_HP1_Orf28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019698": {"description": "Protein of unknown function DUF2583", "go_ids": [], "go_terms": [], "name": "DUF2583", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019699": {"description": "Protein of unknown function DUF2584", "go_ids": [], "go_terms": [], "name": "DUF2584", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019700": {"description": "Anti-sigma-G factor Gin", "go_ids": [], "go_terms": [], "name": "Sigma-G_inhibitor_Gin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019701": {"description": "NinX, bacteriophage P22", "go_ids": [], "go_terms": [], "name": "Phage_P22_NinX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019702": {"description": "Multidrug efflux pump accessory protein AcrZ", "go_ids": ["GO:0042910", "GO:0005886", "GO:1990961"], "go_terms": ["GO:0042910:xenobiotic transmembrane transporter activity:F", "GO:0005886:plasma membrane:C", "GO:1990961:xenobiotic detoxification by transmembrane export across the plasma membrane:P"], "name": "AcrZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019703": {"description": "Inner membrane protein YbjO, dehydrogenase-like", "go_ids": [], "go_terms": [], "name": "YbjO_DH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019704": {"description": "Flagellar assembly regulator FliX, class II", "go_ids": ["GO:0044781"], "go_terms": ["GO:0044781:bacterial-type flagellum organization:P"], "name": "Flagellar_assmbl_FliX_class2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019705": {"description": "Protein of unknown function DUF2594", "go_ids": [], "go_terms": [], "name": "DUF2594", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019707": {"description": "MJ1608-like", "go_ids": [], "go_terms": [], "name": "MJ1608", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019708": {"description": "Bacteriophage HP1, Orf24", "go_ids": [], "go_terms": [], "name": "Phage_HP1_Orf24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019710": {"description": "Domain of unknown function DUF4226", "go_ids": [], "go_terms": [], "name": "DUF4226", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019711": {"description": "ATP synthase, F0 complex, subunit H", "go_ids": ["GO:0015986"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_F0_suH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019712": {"description": "Tetraprenyl-beta-curcumene synthase YtpB-like", "go_ids": [], "go_terms": [], "name": "YtpB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019713": {"description": "Inner membrane protein YlaC", "go_ids": [], "go_terms": [], "name": "Memb_YlaC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019714": {"description": "2-haloacid dehalogenase, DehI", "go_ids": ["GO:0019120"], "go_terms": ["GO:0019120:hydrolase activity, acting on halide bonds, in C-halide compounds:F"], "name": "2-haloacid_dehalogenase_DehI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019715": {"description": "Haemolysin XhlA", "go_ids": [], "go_terms": [], "name": "Haemolysin_XhlA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019716": {"description": "Large ribosomal subunit protein mL53", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL53", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR019717": {"description": "Dextransucrase DSRB", "go_ids": [], "go_terms": [], "name": "Dextransucrase_DSRB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019718": {"description": "Protein of unknown function DUF2602", "go_ids": [], "go_terms": [], "name": "DUF2602", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019719": {"description": "Protein of unknown function DUF2599", "go_ids": [], "go_terms": [], "name": "DUF2599", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019720": {"description": "Plasmid stability protein, StbB", "go_ids": [], "go_terms": [], "name": "Plasmid_stability_protein_StbB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019721": {"description": "NADH-ubiquinone oxidoreductase, 21kDa subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "NADH-UbQ_OxRdtase_su21_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019722": {"description": "HI_0552-like", "go_ids": [], "go_terms": [], "name": "HI_0552_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019723": {"description": "Uncharacterised protein, YfmQ", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YfmQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019724": {"description": "Uncharacterised protein family UPF0763", "go_ids": [], "go_terms": [], "name": "UPF0763", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019725": {"description": "Bacteriophage T4, P15K, RNA polymerase binding", "go_ids": [], "go_terms": [], "name": "Phage_T4_P15K_Rpol-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019726": {"description": "Protein of unknown function DUF2604", "go_ids": [], "go_terms": [], "name": "DUF2604", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019727": {"description": "ATP synthase, F0 complex, subunit F, mitochondria, fungi", "go_ids": ["GO:0015986"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_F0_fsu_mt_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019728": {"description": "Protein of unknown function DUF2605", "go_ids": [], "go_terms": [], "name": "DUF2605", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019729": {"description": "Gloverin-like protein", "go_ids": [], "go_terms": [], "name": "Gloverin-like_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019730": {"description": "Protein of unknown function DUF2606", "go_ids": [], "go_terms": [], "name": "DUF2606", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019731": {"description": "Protein of unknown function DUF2607", "go_ids": [], "go_terms": [], "name": "DUF2607", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019732": {"description": "Sigma-S stabilisation anti-adaptor protein", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "SigmaS_Anti-adapt_IraP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019733": {"description": "Uncharacterised protein family YhfT", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YhfT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019734": {"description": "Tetratricopeptide repeat", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "TPR_rpt", "pathway_ids": ["R-MMU-8939902", "R-XTR-8866654", "R-HSA-5663220", "R-MMU-9013149", "R-DME-9856530", "R-HSA-112382", "R-BTA-983168", "R-HSA-6804115", "R-BTA-8939211", "R-RNO-983189", "R-BTA-179409", "R-BTA-141430", "R-HSA-380284", "R-RNO-9013149", "R-CFA-1799339", "R-MMU-9013404", "R-HSA-8854518", "R-MMU-8957275", "R-HSA-1650814", "R-HSA-4420097", "R-HSA-159230", "R-HSA-141430", "R-HSA-380320", "R-MMU-9833482", "R-BTA-429947", "R-HSA-1268020", "R-SPO-9696273", "R-DDI-2559582", "R-MMU-5668599", "R-SCE-9664873", "R-HSA-429958", "R-HSA-9609523", "R-HSA-4551638", "R-HSA-176408", "R-MMU-5620924", "R-HSA-9018519", "R-HSA-5601884", "R-HSA-68867", "R-HSA-381426", "R-HSA-9610379", "R-HSA-1799339", "R-HSA-176409", "R-HSA-9629569", "R-MMU-8939211", "R-HSA-9865881", "R-DME-3371453", "R-CEL-1799339", "R-HSA-6784531", "R-HSA-2470946", "R-MMU-5578775", "R-HSA-8950505", "R-HSA-1236973", "R-HSA-168325", "R-RNO-9696273", "R-HSA-9648025", "R-HSA-5624138", "R-MMU-674695", "R-MMU-9018519", "R-HSA-9013404", "R-CEL-983189", "R-HSA-9013149", "R-HSA-3301854", "R-MMU-141430", "R-HSA-5619107", "R-DRE-5358565", "R-RNO-174084", "R-HSA-9613829", "R-HSA-8948751", "R-HSA-5689603", "R-MMU-6804115", "R-MMU-5620922", "R-MMU-6782210", "R-RNO-983168", "R-DME-5628897", "R-HSA-5617472", "R-RNO-4420097", "R-HSA-8853884", "R-CEL-5620922", "R-SPO-176408", "R-RNO-3371453", "R-MMU-6782135", "R-SPO-2559580", "R-HSA-76066", "R-MMU-429958", "R-RNO-9909505", "R-RNO-2559584", "R-HSA-2559582", "R-HSA-1169408", "R-HSA-174184", "R-MMU-174048", "R-HSA-9909505", "R-MMU-4615885", "R-RNO-6804115", "R-DME-983189", "R-HSA-168333", "R-RNO-3371568", "R-BTA-2467813", "R-MMU-3214842", "R-RNO-8957275", "R-SPO-983168", "R-HSA-5578775", "R-MMU-5689603", "R-SCE-6782210", "R-HSA-5620912", "R-HSA-9918481", "R-MMU-9648025", "R-HSA-8937144", "R-GGA-429947", "R-RNO-6811434", "R-BTA-9664873", "R-BTA-174048", "R-RNO-6782135", "R-HSA-8852276", "R-XTR-75955", "R-HSA-9679191", "R-HSA-6782135", "R-BTA-6804760", "R-MMU-844456", "R-MMU-176407", "R-HSA-5213460", "R-SCE-9907900", "R-DDI-983168", "R-HSA-418594", "R-SPO-9609523", "R-MMU-983168", "R-HSA-9022699", "R-RNO-5675482", "R-RNO-9865881", "R-RNO-168928", "R-DDI-174178", "R-DRE-6804115", "R-HSA-9696273", "R-HSA-5675221", "R-RNO-1236973", "R-HSA-174178", "R-HSA-9646399", "R-RNO-5625970", "R-HSA-8951664", "R-MMU-4570464", "R-RNO-72163", "R-DRE-2467813", "R-HSA-170822", "R-RNO-8866654", "R-MMU-68877", "R-RNO-9018519", "R-RNO-3299685", "R-MMU-8948751", "R-MMU-5689880", "R-DRE-5624138", "R-CEL-8939211", "R-HSA-8863795", "R-MMU-5610787", "R-HSA-4570464", "R-HSA-749476", "R-SCE-9696273", "R-SCE-5689880", "R-MMU-6811434", "R-MMU-8866654", "R-DDI-6798695", "R-MMU-176409", "R-HSA-3299685", "R-DDI-174084", "R-DDI-204005", "R-MMU-380259", "R-SPO-76066", "R-MMU-3301854", "R-RNO-5675221", "R-DDI-844456", "R-CEL-5620924", "R-MMU-170822", "R-RNO-6804760", "R-DDI-6811438", "R-DME-5218920", "R-HSA-3232142", "R-HSA-8866654", "R-HSA-72163", "R-CEL-674695", "R-DME-3371568", "R-HSA-909733", "R-CEL-112382", "R-RNO-176408", "R-MMU-5357905", "R-BTA-69017", "R-HSA-179409", "R-MMU-3108214", "R-DME-165159", "R-RNO-5620924", "R-DME-9909505", "R-HSA-174154", "R-MMU-3371497", "R-HSA-191859", "R-MMU-3232142", "R-SPO-76061", "R-RNO-174178", "R-DDI-6811434", "R-MMU-174178", "R-MMU-418594", "R-RNO-418594", "R-MMU-5693565", "R-MMU-9865881", "R-BTA-174154", "R-DDI-176409", "R-MMU-429947", "R-MMU-2672351", "R-MMU-2132295", "R-BTA-5578775", "R-HSA-6782210", "R-HSA-4615885", "R-BTA-176407", "R-HSA-3371568", "R-MMU-159231", "R-MMU-3371453", "R-MMU-3214847", "R-DDI-9833482", "R-RNO-2132295", "R-BTA-72165", "R-DDI-3371453", "R-HSA-168271", "R-DDI-2559580", "R-MMU-5675482", "R-MMU-176412", "R-BTA-6804115", "R-BTA-844456", "R-RNO-9013423", "R-MMU-6783310", "R-MMU-174184", "R-RNO-68867", "R-DDI-9664873", "R-HSA-75955", "R-HSA-9821002", "R-HSA-3214847", "R-HSA-674695", "R-HSA-180746", "R-DDI-1799339", "R-RNO-69017", "R-MMU-9696273", "R-HSA-9725370", "R-HSA-5625970", "R-HSA-5668599", "R-RNO-9833482", "R-DME-8939211", "R-HSA-2173788", "R-DME-9639288", "R-HSA-6798695", "R-MMU-1222556", "R-RNO-2559582", "R-HSA-9920588", "R-DME-3371497", "R-MMU-2467813", "R-RNO-5357905", "R-MMU-4420097", "R-DRE-141444", "R-SPO-9664873", "R-MMU-5205685", "R-MMU-2565942", "R-DME-380972", "R-BTA-176409", "R-HSA-9841922", "R-HSA-6781823", "R-MMU-159230", "R-BTA-9033241", "R-MMU-8951664", "R-HSA-3371453", "R-RNO-174154", "R-DME-3371571", "R-RNO-72165", "R-HSA-8939211", "R-RNO-9772755", "R-MMU-381426", "R-RNO-9013404", "R-HSA-5205685", "R-SCE-5668541", "R-RNO-6782210", "R-RNO-141430", "R-SPO-2559582", "R-BTA-174084", "R-RNO-5205685", "R-HSA-9687136", "R-BTA-2559582", "R-MMU-141444", "R-DME-9018519", "R-HSA-9918432", "R-HSA-5675482", "R-XTR-112382", "R-HSA-8876198", "R-RNO-844456", "R-SPO-179409", "R-DDI-174048", "R-MMU-159236", "R-RNO-381426", "R-RNO-174184", "R-MMU-8876198", "R-DDI-141430", "R-BTA-176408", "R-MMU-8854518", "R-BTA-3371497", "R-MMU-6798695", "R-HSA-159236", "R-RNO-2467813", "R-MMU-2173788", "R-BTA-5620924", "R-GGA-6804115", "R-DME-8943724", "R-DDI-8866654", "R-HSA-844456", "R-SCE-6782135", "R-DDI-176408", "R-MMU-8863795", "R-SCE-76066", "R-HSA-2132295", "R-HSA-3108214", "R-RNO-2173788", "R-HSA-1221632", "R-RNO-1222556", "R-RNO-9609523", "R-RNO-176407", "R-HSA-192823", "R-RNO-5668599", "R-BTA-2672351", "R-HSA-2565942", "R-RNO-5689603", "R-MMU-4085377", "R-HSA-1222556", "R-HSA-5610787", "R-DME-166208", "R-DDI-6811440", "R-RNO-8852276", "R-MMU-9609523", "R-SCE-983168", "R-HSA-174084", "R-HSA-176407", "R-BTA-174178", "R-PFA-3371497", "R-DDI-69017", "R-MMU-2500257", "R-MMU-168928", "R-HSA-2500257", "R-BTA-5620922", "R-HSA-168276", "R-CEL-5675221", "R-DME-5620922", "R-DRE-2500257", "R-SCE-2559580", "R-HSA-4085377", "R-MMU-9033241", "R-HSA-983168", "R-HSA-9673324", "R-SPO-3371497", "R-DDI-6807878", "R-HSA-69017", "R-HSA-983189", "R-HSA-9692916", "R-HSA-9931953", "R-HSA-8957275", "R-SCE-9609523", "R-XTR-5620924", "R-RNO-8939211", "R-HSA-380259", "R-HSA-9033241", "R-DDI-174154", "R-MMU-2470946", "R-RNO-6781823", "R-HSA-180910", "R-MMU-9909505", "R-RNO-8948751", "R-BTA-9696273", "R-HSA-9833482", "R-HSA-5689880", "R-MMU-174154", "R-MMU-5624138", "R-RNO-5693565", "R-MMU-69017", "R-DDI-6804760", "R-HSA-5693565", "R-MMU-75955", "R-RNO-8863795", "R-MMU-112382", "R-DDI-179409", "R-BTA-9609523", "R-MMU-380320", "R-RNO-9033241", "R-MMU-4551638", "R-SCE-429958", "R-HSA-6811434", "R-SCE-9033241", "R-HSA-76061", "R-DRE-5663220", "R-DDI-176407", "R-MMU-5620912", "R-DDI-9033241", "R-MMU-174084", "R-BTA-68867", "R-SCE-76061", "R-BTA-72163", "R-MMU-6804760", "R-MMU-68867", "R-HSA-5620924", "R-RNO-176412", "R-XTR-674695", "R-RNO-174048", "R-MMU-72163", "R-MMU-9818564", "R-HSA-429947", "R-HSA-9660826", "R-MMU-2559582", "R-HSA-141444", "R-MMU-380270", "R-HSA-9609690", "R-MMU-3299685", "R-HSA-6783310", "R-HSA-6804760", "R-RNO-5689880", "R-HSA-159231", "R-MMU-9013423", "R-RNO-179409", "R-MMU-9646399", "R-MMU-159227", "R-MMU-3371568", "R-DME-1257604", "R-BTA-8866654", "R-HSA-9820841", "R-DME-1632852", "R-HSA-174048", "R-DME-389357", "R-MMU-5663220", "R-MMU-5675221", "R-HSA-9664873", "R-HSA-5620922", "R-SCE-3371497", "R-RNO-6798695", "R-HSA-9705671", "R-HSA-2467813", "R-HSA-168928", "R-HSA-9772755", "R-HSA-6781827", "R-MMU-8852276", "R-BTA-176412", "R-MMU-179409", "R-SCE-6798695", "R-RNO-3371497", "R-MMU-983189", "R-HSA-2672351", "R-HSA-3371497", "R-MMU-380284", "R-CEL-983168", "R-MMU-9664873", "R-HSA-159227", "R-HSA-9013423", "R-MMU-6781823", "R-HSA-5357905", "R-CEL-5610787", "R-HSA-68877", "R-HSA-165054", "R-DDI-2467813", "R-HSA-2559584", "R-MMU-9772755", "R-HSA-72165", "R-BTA-174184", "R-HSA-9615710", "R-DDI-176412", "R-SPO-429958", "R-MMU-191859", "R-HSA-176412", "R-MMU-176408", "R-HSA-381038", "R-CEL-75955", "R-RNO-9664873", "R-SCE-1236978", "R-HSA-3214842", "R-DRE-9865881", "R-HSA-380270", "R-MMU-5625970", "R-MMU-1236973", "R-SCE-8939211", "R-HSA-8939902", "R-SPO-9033241", "R-RNO-3214847", "R-DDI-174184", "R-MMU-72165", "R-DDI-9609523", "R-HSA-9818564"], "pathways": ["R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-XTR-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-8939211:r:ESR-mediated signaling", "R-RNO-983189:r:Kinesins", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9833482:r:PKR-mediated signaling", "R-BTA-429947:r:Deadenylation of mRNA", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-9696273:r:RND1 GTPase cycle", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SCE-9664873:r:Pexophagy", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9629569:r:Protein hydroxylation", "R-MMU-8939211:r:ESR-mediated signaling", "R-HSA-9865881:r:Complex III assembly", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-CEL-983189:r:Kinesins", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-DRE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5689603:r:UCH proteinases", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early 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"R-GGA-429947:r:Deadenylation of mRNA", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-9664873:r:Pexophagy", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-844456:r:The NLRP3 inflammasome", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-SCE-9907900:r:Proteasome assembly", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418594:r:G alpha (i) signalling events", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-983168:r:Antigen 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"R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-3371568:r:Attenuation phase", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-165159:r:MTOR signalling", "R-RNO-5620924:r:Intraflagellar transport", "R-DME-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-9865881:r:Complex III assembly", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-429947:r:Deadenylation of mRNA", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-3371568:r:Attenuation phase", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3214847:r:HATs acetylate histones", "R-DDI-9833482:r:PKR-mediated signaling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-DDI-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose 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"R-RNO-9833482:r:PKR-mediated signaling", "R-DME-8939211:r:ESR-mediated signaling", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SPO-9664873:r:Pexophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-BTA-9033241:r:Peroxisomal protein import", "R-MMU-8951664:r:Neddylation", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-3371571:r:HSF1-dependent transactivation", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-8939211:r:ESR-mediated signaling", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SCE-5668541:r:TNFR2 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"R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-5620924:r:Intraflagellar transport", "R-GGA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-844456:r:The NLRP3 inflammasome", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-1221632:r:Meiotic synapsis", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-192823:r:Viral mRNA Translation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-2672351:r:Stimuli-sensing channels", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-5689603:r:UCH proteinases", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-166208:r:mTORC1-mediated signalling", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-174178:r:APC/C:Cdh1 mediated 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"R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-983189:r:Kinesins", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9931953:r:Biofilm formation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-XTR-5620924:r:Intraflagellar transport", "R-RNO-8939211:r:ESR-mediated signaling", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-BTA-9696273:r:RND1 GTPase cycle", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-9033241:r:Peroxisomal protein import", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DDI-9033241:r:Peroxisomal protein import", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-176412:r:Phosphorylation of the APC/C", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9646399:r:Aggrephagy", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-3371568:r:Attenuation phase", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-DME-1632852:r:Macroautophagy", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9664873:r:Pexophagy", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-983189:r:Kinesins", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9664873:r:Pexophagy", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-CEL-5610787:r:Hedgehog 'off' state", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-9615710:r:Late endosomal microautophagy", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-191859:r:snRNP Assembly", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-9664873:r:Pexophagy", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-3214842:r:HDMs demethylate histones", "R-DRE-9865881:r:Complex III assembly", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5625970:r:RHO GTPases activate KTN1", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-SCE-8939211:r:ESR-mediated signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-SPO-9033241:r:Peroxisomal protein import", "R-RNO-3214847:r:HATs acetylate histones", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes"], "type": "Repeat"}, "IPR019736": {"description": "Synapsin, phosphorylation site", "go_ids": [], "go_terms": [], "name": "Synapsin_P_site", "pathway_ids": ["R-HSA-181429", "R-RNO-212676", "R-MMU-212676", "R-HSA-9662360", "R-RNO-181429", "R-MMU-181429", "R-HSA-212676"], "pathways": ["R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle"], "type": "PTM"}, "IPR019748": {"description": "FERM central domain", 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"R-MMU-2453902", "R-HSA-8950505", "R-CEL-114608", "R-HSA-6785807", "R-HSA-8854691", "R-CEL-446353", "R-MMU-9705462", "R-RNO-418885", "R-HSA-982772", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-8866427", "R-DRE-446353", "R-HSA-9860927", "R-HSA-9674555", "R-HSA-372708", "R-RNO-983168", "R-RNO-4420097", "R-MMU-375165", "R-MMU-69231", "R-HSA-449836", "R-DRE-9705462", "R-HSA-418885", "R-HSA-1169408", "R-DRE-110056", "R-RNO-354194", "R-HSA-3214858", "R-CEL-9013149", "R-MMU-372708", "R-BTA-114608", "R-HSA-6802946", "R-HSA-912694", "R-MMU-6788467", "R-RNO-373752", "R-BTA-373752", "R-HSA-354192", "R-MMU-8854691", "R-RNO-112411", "R-HSA-9013420", "R-SSC-9027276", "R-SSC-9020956", "R-MMU-8984722", "R-HSA-9662361", "R-MMU-6794361", "R-HSA-9031525", "R-DRE-9020958", "R-HSA-354194", "R-HSA-9679191", "R-HSA-1433557", "R-MMU-9006335", "R-MMU-877300", "R-HSA-9705462", "R-MMU-983168", "R-HSA-9022699", "R-MMU-9696270", "R-HSA-9696273", "R-HSA-2453902", "R-HSA-8874081", "R-HSA-9020958", "R-HSA-6802952", "R-RNO-372708", "R-RNO-9020558", "R-RNO-9020591", "R-HSA-9732724", "R-HSA-69231", "R-HSA-9027284", "R-RNO-512988", "R-HSA-5675221", "R-SSC-9020933", "R-MMU-9020958", "R-HSA-9662360", "R-MMU-9732724", "R-DME-2453902", "R-RNO-375165", "R-HSA-512988", "R-SSC-9705462", "R-SSC-1170546", "R-MMU-909733", "R-CFA-6794361", "R-CEL-182971", "R-HSA-6802955", "R-DME-446353", "R-HSA-8984722", "R-HSA-9931295", "R-MMU-9035034", "R-DRE-112411", "R-HSA-1170546", "R-HSA-6802948", "R-MMU-399955", "R-HSA-437239", "R-MMU-5673000", "R-RNO-9705462", "R-RNO-9013148", "R-HSA-373752", "R-HSA-9008059", "R-MMU-912526", "R-DRE-6785807", "R-HSA-909733", "R-MMU-9696264", "R-RNO-9013420", "R-MMU-6785807", "R-MMU-354192", "R-DDI-9013418", "R-HSA-9833109", "R-MMU-5674135", "R-HSA-1059683", "R-RNO-8980692", "R-DRE-877312", "R-HSA-6788467", "R-SSC-8854691", "R-DDI-9013422", "R-RNO-9860927", "R-DRE-983168", "R-RNO-8874081", "R-HSA-114608", "R-MMU-9020591", "R-RNO-354192", "R-HSA-877312", "R-HSA-9013148", "R-RNO-3928662", "R-RNO-6788467", "R-HSA-399719", "R-RNO-437239", "R-HSA-9696270", "R-MMU-354194", "R-RNO-399719", "R-HSA-110056", "R-HSA-9634638", "R-HSA-8866427", "R-HSA-9009391", "R-HSA-446353", "R-DME-6794361", "R-HSA-9027277", "R-MMU-9696273", "R-HSA-9725370", "R-HSA-391160", "R-HSA-6798695", "R-RNO-877300", "R-SSC-9020591", "R-HSA-166016", "R-DRE-1266695", "R-HSA-112411", "R-SSC-6785807", "R-MMU-4420097", "R-HSA-9670439", "R-RNO-9027276", "R-RNO-912526", "R-DME-2029482", "R-HSA-399955", "R-DRE-877300", "R-RNO-5673001", "R-RNO-8866427", "R-HSA-1266695", "R-MMU-1433557", "R-DME-437239", "R-RNO-8984722", "R-HSA-2029482", "R-HSA-9020933", "R-DRE-8854691", "R-SSC-512988", "R-HSA-5673001", "R-RNO-1433557", "R-MMU-9027276", "R-RNO-6794361", "R-DRE-6788467", "R-DRE-9013423", "R-MMU-114608", "R-RNO-9674555", "R-MMU-112411", "R-RNO-1059683", "R-MMU-9013148", "R-MMU-983231", "R-HSA-1660499", "R-HSA-375165", "R-RNO-2029482", "R-HSA-6794361", "R-RNO-5663213", "R-MMU-9931295", "R-SSC-877312", "R-HSA-9035034", "R-RNO-110056", "R-DRE-9013149", "R-MMU-110056", "R-DRE-1059683", "R-HSA-9020591", "R-MMU-1170546", "R-HSA-445355", "R-CEL-5675221", "R-RNO-982772", "R-HSA-983168", "R-MMU-1169408", "R-MMU-2029482", "R-SSC-5673001", "R-MMU-1059683", "R-MMU-6783783", "R-HSA-5627123", "R-MMU-3928662", "R-HSA-9664422", "R-MMU-912694", "R-DME-9013423", "R-MMU-399719", "R-SSC-6788467", "R-MMU-418885", "R-HSA-5663213", "R-SSC-5673000", "R-RNO-6785807", "R-MMU-1266695", "R-MMU-9674555", "R-HSA-9006335", "R-RNO-9009391", "R-SSC-69231", "R-SSC-912526", "R-MMU-9009391", "R-MMU-445355", "R-DDI-114608", "R-RNO-8854691", "R-RNO-877312", "R-RNO-111465", "R-HSA-5673000", "R-MMU-5663213", "R-MMU-9013420", "R-RNO-983231", "R-SSC-112411", "R-SSC-982772", "R-MMU-5673001", "R-HSA-2586552", "R-SSC-9674555", "R-HSA-9027283", "R-RNO-5673000", "R-DME-9013149", "R-HSA-182971", "R-RNO-9732724", "R-DME-114608", "R-DME-5627123", "R-HSA-983231", "R-DRE-909733", "R-DRE-912694", "R-HSA-8983432", "R-SSC-9027284", "R-HSA-9696264", "R-MMU-9013423", "R-RNO-9006335", "R-DRE-8983432", "R-MMU-5627123", "R-SSC-1433557", "R-HSA-8985947", "R-MMU-9860927", "R-MMU-5675221", "R-HSA-9656223"], "pathways": ["R-DME-373752:r:Netrin-1 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-6794361:r:Neurexins and neuroligins", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-MMU-8983432:r:Interleukin-15 signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-MMU-9020933:r:Interleukin-23 signaling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-9020558:r:Interleukin-2 signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-982772:r:Growth hormone receptor signaling", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CEL-114608:r:Platelet degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-DRE-446353:r:Cell-extracellular matrix interactions", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-372708:r:p130Cas 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"R-HSA-6783783", "R-RNO-201556", "R-RNO-9020933", "R-SSC-8984722", "R-MMU-166016", "R-MMU-982772", "R-MMU-2453902", "R-HSA-8950505", "R-CEL-114608", "R-HSA-6785807", "R-HSA-8854691", "R-CEL-446353", "R-MMU-9705462", "R-RNO-418885", "R-HSA-982772", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-8866427", "R-DRE-446353", "R-HSA-9860927", "R-HSA-9674555", "R-HSA-372708", "R-RNO-983168", "R-RNO-4420097", "R-MMU-375165", "R-MMU-69231", "R-CEL-375165", "R-HSA-449836", "R-DRE-9705462", "R-HSA-418885", "R-HSA-1169408", "R-DRE-110056", "R-RNO-354194", "R-HSA-3214858", "R-CEL-9013149", "R-MMU-372708", "R-CEL-418885", "R-BTA-114608", "R-HSA-6802946", "R-HSA-912694", "R-MMU-6788467", "R-RNO-373752", "R-BTA-373752", "R-HSA-354192", "R-MMU-8854691", "R-RNO-112411", "R-HSA-9013420", "R-SSC-9027276", "R-SSC-9020956", "R-MMU-8984722", "R-HSA-9662361", "R-MMU-6794361", "R-HSA-9031525", "R-DRE-9020958", "R-HSA-354194", "R-HSA-9679191", "R-HSA-1433557", "R-MMU-9006335", "R-MMU-877300", "R-CEL-2029482", "R-HSA-9705462", "R-MMU-983168", "R-HSA-9022699", "R-DME-209228", "R-MMU-9696270", "R-HSA-9696273", "R-HSA-2453902"], "pathways": ["R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-9020591:r:Interleukin-12 signaling", "R-DME-9020558:r:Interleukin-2 signaling", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-CFA-6794361:r:Neurexins and neuroligins", "R-CEL-182971:r:EGFR downregulation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-437239:r:Recycling pathway of L1", "R-MMU-5673000:r:RAF activation", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-354192:r:Integrin signaling", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-DRE-877312:r:Regulation of IFNG signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-9020591:r:Interleukin-12 signaling", "R-RNO-354192:r:Integrin signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-DME-6794361:r:Neurexins and neuroligins", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-877300:r:Interferon gamma signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DRE-1266695:r:Interleukin-7 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-8983432:r:Interleukin-15 signaling", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-877300:r:Interferon gamma signaling", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-HSA-1266695:r:Interleukin-7 signaling", "R-DME-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5673000:r:RAF activation", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-437239:r:Recycling pathway of L1", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-6794361:r:Neurexins and neuroligins", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-MMU-114608:r:Platelet degranulation", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-877312:r:Regulation of IFNG signaling", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-DRE-1059683:r:Interleukin-6 signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-445355:r:Smooth Muscle Contraction", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-8985947:r:Interleukin-9 signaling", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-5673000:r:RAF activation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5673000:r:RAF activation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-SSC-982772:r:Growth hormone receptor signaling", "R-DME-209209:r:Formation of the activated receptor complex", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-RNO-5673000:r:RAF activation", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-DME-114608:r:Platelet degranulation", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-8985947:r:Interleukin-9 signaling", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-DRE-8983432:r:Interleukin-15 signaling", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-DME-373752:r:Netrin-1 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-6794361:r:Neurexins and neuroligins", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-MMU-8983432:r:Interleukin-15 signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-201556:r:Signaling by ALK", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-MMU-9020933:r:Interleukin-23 signaling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-DME-1266695:r:Interleukin-7 signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-RNO-201556:r:Signaling by ALK", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-982772:r:Growth hormone receptor signaling", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CEL-114608:r:Platelet degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-DRE-446353:r:Cell-extracellular matrix interactions", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-MMU-69231:r:Cyclin D associated events in G1", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-449836:r:Other interleukin signaling", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CEL-418885:r:DCC mediated attractive signaling", "R-BTA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-373752:r:Netrin-1 signaling", "R-BTA-373752:r:Netrin-1 signaling", "R-HSA-354192:r:Integrin signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9013420:r:RHOU GTPase cycle", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-DRE-9020958:r:Interleukin-21 signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-MMU-877300:r:Interferon gamma signaling", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Domain"}, "IPR019752": {"description": "Pyruvate/ketoisovalerate oxidoreductase, catalytic domain", "go_ids": ["GO:0016903"], "go_terms": ["GO:0016903:oxidoreductase activity, acting on the aldehyde or oxo group of donors:F"], "name": "Pyrv/ketoisovalerate_OxRed_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019755": {"description": "Restriction endonuclease, type II, EcoRV, Proteobacteria", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_EcoRV_Pbac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019766": {"description": "Signal peptidase I, all-beta subdomain", "go_ids": [], "go_terms": [], "name": "Sign_pep_all-beta_subdom", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Homologous_superfamily"}, "IPR019773": {"description": "Tyrosine 3-monooxygenase-like", "go_ids": ["GO:0016714"], "go_terms": ["GO:0016714:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen:F"], "name": "Tyrosine_3-monooxygenase-like", "pathway_ids": ["R-HSA-2160456", "R-HSA-8964208", "R-MMU-209905", "R-DDI-209931", "R-DME-209905", "R-HSA-209905", "R-DME-8964208", "R-BTA-8964208", "R-MMU-8964208", "R-CEL-209905", "R-RNO-8964208", "R-RNO-209905", "R-HSA-209931", "R-DDI-8964208", "R-CEL-8964208", "R-HSA-9031628", "R-DDI-209905", "R-RNO-209931", "R-MMU-209931"], "pathways": ["R-HSA-2160456:r:Phenylketonuria", "R-HSA-8964208:r:Phenylalanine metabolism", "R-MMU-209905:r:Catecholamine biosynthesis", "R-DDI-209931:r:Serotonin and melatonin biosynthesis", "R-DME-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-DME-8964208:r:Phenylalanine metabolism", "R-BTA-8964208:r:Phenylalanine metabolism", "R-MMU-8964208:r:Phenylalanine metabolism", "R-CEL-209905:r:Catecholamine biosynthesis", "R-RNO-8964208:r:Phenylalanine metabolism", "R-RNO-209905:r:Catecholamine biosynthesis", 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gene expression by MLL3 and MLL4 complexes", "R-DME-114608:r:Platelet degranulation", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9031628:r:NGF-stimulated transcription", "R-HSA-167161:r:HIV Transcription Initiation", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", 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"R-DME-9031628:r:NGF-stimulated transcription", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-RNO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-3214842:r:HDMs demethylate histones", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-DME-209407:r:Transport of ARM to the nucleus", "R-SCE-6811555:r:PI5P Regulates TP53 Acetylation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-9909649:r:Regulation 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["GO:0030492", "GO:0009274", "GO:0015886"], "go_terms": ["GO:0030492:hemoglobin binding:F", "GO:0009274:peptidoglycan-based cell wall:C", "GO:0015886:heme transport:P"], "name": "Haem_uptake_protein_IsdC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019910": {"description": "Luciferase-like, F420-dependent oxidoreductase, MSMEG4879, predicted", "go_ids": [], "go_terms": [], "name": "Lucif-like_OxRdtase_MSMEG_4879", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019911": {"description": "Alkanesulphonate monooxygenase, FMN-dependent", "go_ids": ["GO:0008726"], "go_terms": ["GO:0008726:alkanesulfonate monooxygenase activity:F"], "name": "Alkanesulphonate_mOase_FMN-dep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019912": {"description": "FMN reductase, MsuE-like", "go_ids": [], "go_terms": [], "name": "FMN_Rdtase_MsuE-like", "pathway_ids": ["PWY-681", "PWY-7723"], "pathways": ["PWY-681:t:dibenzothiophene desulfurization", "PWY-7723:t:bacterial 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transporter activity:F"], "name": "Pyrimidine_permease_RutG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019919": {"description": "Luciferase-like, F420-dependent oxidoreductase, MSMEG2256, predicted", "go_ids": [], "go_terms": [], "name": "Lucif-like_OxRdtase_MSMEG_2256", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019920": {"description": "F420-binding domain, putative", "go_ids": [], "go_terms": [], "name": "F420-binding_dom_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019921": {"description": "Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted", "go_ids": [], "go_terms": [], "name": "Lucif-like_OxRdtase_Rv2161c", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019922": {"description": "Luciferase-like, F420-dependent oxidoreductase, MSMEG4141, predicted", "go_ids": [], "go_terms": [], "name": "Lucif-like_OxRdatse_MSMEG_4141", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019923": {"description": 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"R-HSA-5368286", "R-CEL-5389840", "R-MMU-9937383", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-CEL-5419276", "R-HSA-5389840", "R-RNO-9937383", "R-MMU-5389840"], "pathways": ["R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR019928": {"description": "Large ribosomal subunit protein uL3, archaea", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uL3_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019929": {"description": "Iron-regulated surface determinant protein IsdB", "go_ids": ["GO:0015886", "GO:0015232", "GO:0005618"], "go_terms": ["GO:0015886:heme transport:P", "GO:0015232:heme transmembrane transporter activity:F", "GO:0005618:cell wall:C"], "name": "Iron-reg_IsdB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019930": {"description": "Iron-regulated surface determinant protein H", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "IsdH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019931": {"description": "LPXTG cell wall anchor motif", "go_ids": [], "go_terms": [], "name": "LPXTG_anchor", "pathway_ids": ["R-HSA-8876493"], "pathways": ["R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells"], "type": "Conserved_site"}, "IPR019932": {"description": "Conserved hypothetical protein CHP03543", "go_ids": [], "go_terms": [], "name": "CHP03543", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019933": {"description": "DivIVA domain", "go_ids": [], "go_terms": [], "name": "DivIVA_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019934": {"description": "Conserved hypothetical protein CHP03545", "go_ids": [], "go_terms": [], "name": "CHP03545", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019935": {"description": "Conserved hypothetical protein CHP03546", "go_ids": [], "go_terms": [], "name": "CHP03546", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019936": {"description": "N-acetylneuraminate epimerase, proteobacteria", "go_ids": [], "go_terms": [], "name": "NanM_proteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019937": {"description": "Cyclically-permuted mutarotase family", "go_ids": [], "go_terms": [], "name": "Cycl-permuted_mutarotase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019938": {"description": "YcaO domain protein", "go_ids": [], "go_terms": [], "name": "YcaO_dom_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019939": {"description": "CofG family", "go_ids": ["GO:0016765", "GO:0051539"], "go_terms": ["GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "CofG_family", "pathway_ids": ["PWY-8113", "PWY-8112", "PWY-5198"], "pathways": ["PWY-8113:t:3PG-factor 420 biosynthesis", "PWY-8112:t:factor 420 biosynthesis I (archaea)", "PWY-5198:t:factor 420 biosynthesis II (mycobacteria)"], "type": "Family"}, "IPR019940": {"description": "CofH family", "go_ids": ["GO:0016765"], "go_terms": ["GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "CofH_family", "pathway_ids": ["PWY-8113", "PWY-8112", "PWY-5198"], "pathways": ["PWY-8113:t:3PG-factor 420 biosynthesis", "PWY-8112:t:factor 420 biosynthesis I (archaea)", "PWY-5198:t:factor 420 biosynthesis II (mycobacteria)"], "type": "Family"}, "IPR019941": {"description": "Transcription regulator LuxR, chaperone HchA-associated", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_LuxR_HchA-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019942": {"description": "LL-diaminopimelate aminotransferase/aminotransferase ALD1", "go_ids": ["GO:0008483"], "go_terms": ["GO:0008483:transaminase activity:F"], "name": "DapL/ALD1", "pathway_ids": ["PWY-5097"], "pathways": ["PWY-5097:t:L-lysine biosynthesis VI"], "type": "Family"}, "IPR019943": {"description": "Coenzyme F420 biosynthesis protein FbiB, C-terminal", "go_ids": ["GO:0016881"], "go_terms": ["GO:0016881:acid-amino acid ligase activity:F"], "name": "F420_FbiB_C", "pathway_ids": ["PWY-5199", "PWY-5198"], "pathways": ["PWY-5199:t:factor 420 polyglutamylation", "PWY-5198:t:factor 420 biosynthesis II (mycobacteria)"], "type": "Domain"}, "IPR019944": {"description": "F420-dependent glucose-6-phosphate dehydrogenase", "go_ids": [], "go_terms": [], "name": "F420-dep_G6P_DH", "pathway_ids": ["R-HSA-1222541"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis"], "type": "Family"}, "IPR019945": {"description": "F420-dependent glucose-6-phosphate dehydrogenase-related", "go_ids": [], "go_terms": [], "name": "F420_G6P_DH-rel", "pathway_ids": ["R-HSA-1222541"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis"], "type": "Family"}, "IPR019946": {"description": "5,10-methylenetetrahydromethanopterin reductase", "go_ids": ["GO:0018537"], "go_terms": ["GO:0018537:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity:F"], "name": "MeH4methanopterin_reductase", "pathway_ids": ["PWY-5209", "PWY-7784", "PWY-8305"], "pathways": ["PWY-5209:t:methyl-coenzyme M oxidation to CO2 I", "PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)", "PWY-8305:t:methoxylated aromatic compound degradation II"], "type": "Family"}, "IPR019947": {"description": "DNA photolyase class 1, 8-HDF type", "go_ids": [], "go_terms": [], "name": "Photolyase_8HDF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019949": {"description": "N-acetyl-S-alkylcysteine monooxygenase-like", "go_ids": [], "go_terms": [], "name": "CmoO-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019951": {"description": "F420-dependent oxidoreductase-predicted, Rv3520c", "go_ids": [], "go_terms": [], "name": "F420_OxRdatse_Rv3520c_pred", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019952": {"description": "F420-dependent oxidoreductase-predicted, Rv1855c", "go_ids": [], "go_terms": [], "name": "F420_OxRdatse_Rv1855c_pred", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019953": {"description": "Organic hydroperoxide resistance protein famiy", "go_ids": ["GO:0006979"], "go_terms": ["GO:0006979:response to oxidative stress:P"], "name": "OHR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019957": {"description": "ABC transporter, high-affinity heme uptake system protein IsdE", "go_ids": ["GO:0015886", "GO:0020037", "GO:0016020"], "go_terms": ["GO:0015886:heme transport:P", "GO:0020037:heme binding:F", "GO:0016020:membrane:C"], "name": "ABC_transptr_haem-bd_IsdE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019958": {"description": "Small ribosomal subunit protein uS9, archaea", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uS9_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019959": {"description": "T1SS-143 repeat-containing domain", "go_ids": [], "go_terms": [], "name": "T1SS-143_rpt-cont_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019960": {"description": "Type I secretion C-terminal target domain, VC_A0849 subclass", "go_ids": [], "go_terms": [], "name": "T1SS_VCA0849", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019961": {"description": "Small ribosomal subunit protein uS11, archaea", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uS11_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019962": {"description": "Conserved hypothetical protein CHP03663", "go_ids": [], "go_terms": [], "name": "CHP03663", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019963": {"description": "Futalosine hydrolase", "go_ids": ["GO:0009234", "GO:0016799"], "go_terms": ["GO:0009234:menaquinone biosynthetic process:P", "GO:0016799:hydrolase activity, hydrolyzing N-glycosyl compounds:F"], "name": "FL_hydrolase_MqnB", "pathway_ids": ["PWY-7374"], "pathways": ["PWY-7374:t:1,4-dihydroxy-6-naphthoate biosynthesis I"], "type": "Family"}, "IPR019964": {"description": "KH domain protein, archaea", "go_ids": [], "go_terms": [], "name": "KH_domain_protein_archaea", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019965": {"description": "PPOX class F420-dependent enzyme, family Rv2061, putative", "go_ids": [], "go_terms": [], "name": "PPOX_F420-dep_Rv2061_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019966": {"description": "F420-dependent enzyme, PPOX class, family Rv3369, probable", "go_ids": [], "go_terms": [], "name": "F420-dep_enz_PPOX_Rv3369", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019967": {"description": "F420-dependent enzyme, PPOX class, family Rv0121, probable", "go_ids": [], "go_terms": [], "name": "F420-dep_enz_PPOX_Rv0121", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019968": {"description": "Urea ABC transporter, substrate-binding protein", "go_ids": [], "go_terms": [], "name": "Urea_ABC_transptr_substrate-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019969": {"description": "DNA-directed RNA polymerase subunit Rpo2", "go_ids": ["GO:0003677", "GO:0003899", "GO:0006351", "GO:0008270"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006351:DNA-templated transcription:P", "GO:0008270:zinc ion binding:F"], "name": "RNAP_Rpo2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019970": {"description": "Large ribosomal subunit protein uL4, archaea", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412", "GO:0019843"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P", "GO:0019843:rRNA binding:F"], "name": "Ribosomall_uL4-arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019971": {"description": "Large ribosomal subunit protein uL14, archaea", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL14_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019973": {"description": "Flap endonuclease, archaea", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "Flap_endonuc_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019975": {"description": "Transcription termination factor CPSF1, archaea", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "aCPSF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019977": {"description": "Small ribosomal subunit protein uS13, archaea", "go_ids": ["GO:0003723", "GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003723:RNA 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["GO:0004298", "GO:0005839", "GO:0030163"], "go_terms": ["GO:0004298:threonine-type endopeptidase activity:F", "GO:0005839:proteasome core complex:C", "GO:0030163:protein catabolic process:P"], "name": "Proteasome_asu_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019983": {"description": "Peptidase T1A, proteasome beta-subunit, archaeal", "go_ids": ["GO:0004175", "GO:0005839", "GO:0030163"], "go_terms": ["GO:0004175:endopeptidase activity:F", "GO:0005839:proteasome core complex:C", "GO:0030163:protein catabolic process:P"], "name": "Pept_T1A_Psome_bsu_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019984": {"description": "Small ribosomal subunit protein uS17, bacteria/chloroplast", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uS17_bact/chlr", "pathway_ids": [], "pathways": [], "type": "Family"}, 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"R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR019986": {"description": "Protein YloV-like", "go_ids": [], "go_terms": [], "name": "YloV-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019987": {"description": "GTP-binding protein, ribosome biogenesis, YsxC", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "GTP-bd_ribosome_bio_YsxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019988": {"description": "GTP-binding protein, riobosome biogenesis, YqeH", "go_ids": [], "go_terms": [], "name": "GTP-bd_ribosome_bgen_YqeH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019989": {"description": "CRISPR-associated protein Cas8a1/Csx13, Myxan subtype, N-terminal", "go_ids": ["GO:0051607"], "go_terms": ["GO:0051607:defense response to virus:P"], "name": "CRISPR-assoc_Csx13_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR019991": {"description": "GTP-binding protein, ribosome biogenesis", "go_ids": [], "go_terms": [], "name": "GTP-bd_ribosome_bgen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019992": {"description": "Mycoides cluster lipoprotein, LppA/p72", "go_ids": [], "go_terms": [], "name": "Mycoides_lipoprot_LppA/p72", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019993": {"description": "RecB family nuclease, TM0106, putative", "go_ids": [], "go_terms": [], "name": "RecB_nuclease_TM0106_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019994": {"description": "Lipid-A-disaccharide synthase-related protein, putative", "go_ids": [], "go_terms": [], "name": "Lipid-A-disac_synthase-rel_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019995": {"description": "Cellulose biosynthesis protein BcsF", "go_ids": [], "go_terms": [], "name": "Cellulose_BcsF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR019996": {"description": "Salicylate synthase", "go_ids": ["GO:0008909", "GO:0016833"], "go_terms": ["GO:0008909:isochorismate synthase activity:F", "GO:0016833:oxo-acid-lyase activity:F"], "name": "Salicylate_synthase", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-5837", "PWY-5901", "PWY-3461", "PWY-8321", "PWY-6627", "PWY-6406"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-5837:t:2-carboxy-1,4-naphthoquinol biosynthesis", "PWY-5901:t:2,3-dihydroxybenzoate biosynthesis", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-8321:t:salicylate biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6406:t:salicylate biosynthesis I"], "type": "Family"}, "IPR019999": {"description": "Anthranilate synthase component I-like", "go_ids": ["GO:0009058"], "go_terms": ["GO:0009058:biosynthetic process:P"], "name": "Anth_synth_I-like", "pathway_ids": ["PWY-6661", "PWY-5958"], "pathways": ["PWY-6661:t:4-hydroxy-2(1H)-quinolone biosynthesis", "PWY-5958:t:acridone alkaloid biosynthesis"], "type": "Family"}, "IPR020000": {"description": "Bacteriophage P2, LysB", "go_ids": [], "go_terms": [], "name": "Phage_P2_LysB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020004": {"description": "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "go_ids": ["GO:0004553", "GO:0006047"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F", "GO:0006047:UDP-N-acetylglucosamine metabolic process:P"], "name": "UDP-GlcNAc_Epase", "pathway_ids": ["PWY-6138", "PWY-6139", "R-HSA-4085001", "R-HSA-4085011", "R-MMU-4085001", "R-RNO-4085001"], "pathways": ["PWY-6138:t:CMP-N-acetylneuraminate biosynthesis I (eukaryotes)", "PWY-6139:t:CMP-N-acetylneuraminate biosynthesis II (bacteria)", "R-HSA-4085001:r:Sialic acid metabolism", "R-HSA-4085011:r:Defective GNE causes sialuria, NK and IBM2", "R-MMU-4085001:r:Sialic acid metabolism", "R-RNO-4085001:r:Sialic acid metabolism"], "type": "Family"}, "IPR020005": {"description": "Flagellar export ATPase FliI, clade 1", "go_ids": ["GO:0044780", "GO:0016887", "GO:0071973"], "go_terms": ["GO:0044780:bacterial-type flagellum assembly:P", "GO:0016887:ATP hydrolysis activity:F", "GO:0071973:bacterial-type flagellum-dependent cell motility:P"], "name": "FliI_clade1", "pathway_ids": ["PWY-7980"], "pathways": ["PWY-7980:t:ATP biosynthesis"], "type": "Family"}, "IPR020006": {"description": "Flagellar biosynthesis protein FlhF", "go_ids": ["GO:0003924", "GO:0044781"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0044781:bacterial-type flagellum organization:P"], "name": "FlhF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020007": {"description": "NeuB/NeuA acid synthase", "go_ids": [], "go_terms": [], "name": "NeuB/NeuA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020008": {"description": "GlyGly-CTERM domain", "go_ids": [], "go_terms": [], "name": "GlyGly_CTERM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020009": {"description": "VolA/Pla-1/cef phospholipase", "go_ids": [], "go_terms": [], "name": "VolA/Pla-1/cef", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020010": {"description": "Conserved hypothetical protein CHP03503", "go_ids": [], "go_terms": [], "name": "CHP03503", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020011": {"description": "FimV, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FimV_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020012": {"description": "FimV, LysM domain", "go_ids": [], "go_terms": [], "name": "LysM_FimV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020013": {"description": "Flagellar hook-basal body protein, FlgE/F/G", "go_ids": [], "go_terms": [], "name": "Flagellar_FlgE/F/G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020014": {"description": "Decahaem cytochrome, c-type, OmcA/MtrC", "go_ids": [], "go_terms": [], "name": "Decahaem_cyt-c_OmcA/MtrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020015": {"description": "Decaheme cytochrome, c-type, DmsE", "go_ids": [], "go_terms": [], "name": "Decahaem_cyt-c_DmsE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020016": {"description": "Decahaem-associated outer membrane protein, MtrB/PioB", "go_ids": [], "go_terms": [], "name": "Decahaem-assoc_OM_MtrB/PioB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020017": {"description": "XapX domain", "go_ids": [], "go_terms": [], "name": "XapX_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020018": {"description": "Gliding motility-associated lipoprotein, GldH", "go_ids": [], "go_terms": [], "name": "Motility-assoc_lipoprot_GldH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020019": {"description": "Acyltransferase PglD-like", "go_ids": [], "go_terms": [], "name": "AcTrfase_PglD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020020": {"description": "Luciferase-type oxidoreductase", "go_ids": [], "go_terms": [], "name": "Luciferase-type_oxidoreductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020021": {"description": "Glycosyl amidation-associated protein, WbuZ", "go_ids": ["GO:0016833"], "go_terms": ["GO:0016833:oxo-acid-lyase activity:F"], "name": "Glycosyl_amidation-assoc_WbuZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020022": {"description": "N-acetyl sugar amidotransferase", "go_ids": [], "go_terms": [], "name": "N-acetyl_sugar_amidoTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020023": {"description": "UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase", "go_ids": [], "go_terms": [], "name": "PseG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020024": {"description": "L-seryl-tRNA(Sec) kinase, archaea", "go_ids": ["GO:0001717", "GO:0016301", "GO:0016773"], "go_terms": ["GO:0001717:conversion of seryl-tRNAsec to selenocys-tRNAsec:P", "GO:0016301:kinase activity:F", "GO:0016773:phosphotransferase activity, alcohol group as acceptor:F"], "name": "L-seryl-tRNA_Sec_kinase_arc", "pathway_ids": ["PWY-6281"], "pathways": ["PWY-6281:t:L-selenocysteine biosynthesis II (archaea and eukaryotes)"], "type": "Family"}, "IPR020025": {"description": "UDP-N-acetylglucosamine 4,6-dehydratase (inverting)", "go_ids": [], "go_terms": [], "name": "PseB", "pathway_ids": ["PWY-7719", "PWY-7330", "PWY-7332", "PWY-6143", "PWY-7331"], "pathways": ["PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7330:t:UDP-N-acetyl-beta-L-fucosamine biosynthesis", "PWY-7332:t:superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis", "PWY-6143:t:CMP-pseudaminate biosynthesis", "PWY-7331:t:UDP-N-acetyl-beta-L-quinovosamine biosynthesis"], "type": "Family"}, "IPR020026": {"description": "UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase", "go_ids": [], "go_terms": [], "name": "PseC", "pathway_ids": ["PWY-7842", "PWY-6143", "PWY-7467"], "pathways": ["PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-6143:t:CMP-pseudaminate biosynthesis", "PWY-7467:t:UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-galactose biosynthesis"], "type": "Family"}, "IPR020027": {"description": "Pseudaminic acid biosynthesis-associated methyltransferase", "go_ids": [], "go_terms": [], "name": "Pseudamin_synth-assoc_MeTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020028": {"description": "L-seryl-tRNA(Sec)kinase, eukaryote", "go_ids": [], "go_terms": [], "name": "L-seryl-tRNA_Sec_kinase_euk", "pathway_ids": ["R-HSA-2408557"], "pathways": ["R-HSA-2408557:r:Selenocysteine synthesis"], "type": "Family"}, "IPR020029": {"description": "CRISPR-associated protein Csp2", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Csp2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020030": {"description": "Pseudaminic acid biosynthesis, PseI", "go_ids": [], "go_terms": [], "name": "Pseudaminic_synth_PseI", "pathway_ids": ["PWY-6143"], "pathways": ["PWY-6143:t:CMP-pseudaminate biosynthesis"], "type": "Family"}, "IPR020031": {"description": "CRISPR-associated protein Cas5p", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Cas5p", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020032": {"description": "CRISPR-associated protein Csp1", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Csp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020033": {"description": "Pyridoxal phosphate-dependent transferase, archaea", "go_ids": [], "go_terms": [], "name": "PyrdxlP-dep_transferase_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020034": {"description": "Conserved hypothetical protein CHP03577, EF0830/AHA3911", "go_ids": [], "go_terms": [], "name": "CHP03577_EF0830/AHA3911", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020036": {"description": "UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase", "go_ids": [], "go_terms": [], "name": "PseH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020037": {"description": "Protein of unknown function DUF4312", "go_ids": [], "go_terms": [], "name": "DUF4312", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020038": {"description": "Circular bacteriocin", "go_ids": [], "go_terms": [], "name": "Circ_bacteriocin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020039": {"description": "Pseudaminic acid cytidylyltransferase", "go_ids": [], "go_terms": [], "name": "PseF", "pathway_ids": ["PWY-6143"], "pathways": ["PWY-6143:t:CMP-pseudaminate biosynthesis"], "type": "Family"}, "IPR020040": {"description": "Large ribosomal subunit protein uL6, alpha-beta domain", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412", "GO:0019843"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P", "GO:0019843:rRNA binding:F"], "name": "Ribosomal_uL6_a/b-dom", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954716", "R-CEL-9954714", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-SPO-9954709", "R-SPO-975956", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-CEL-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", 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"R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR020042": {"description": "Protein of unknown function DUF4311", "go_ids": [], "go_terms": [], "name": "DUF4311", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020043": {"description": "Deacetylase Atu3266-like", "go_ids": ["GO:0019213"], "go_terms": ["GO:0019213:deacetylase activity:F"], "name": "Deacetylase_Atu3266-like", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Family"}, "IPR020044": {"description": "PRD domain protein, EF0829/AHA3910", "go_ids": [], "go_terms": [], "name": "PRD_EF0829/AHA3910", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020045": {"description": "DNA polymerase I-like, H3TH domain", "go_ids": ["GO:0003677", "GO:0003824"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003824:catalytic activity:F"], "name": "DNA_polI_H3TH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020046": {"description": "5'-3' exonuclease, alpha-helical arch, N-terminal", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "5-3_exonucl_a-hlix_arch_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020048": {"description": "NADPH-dependent FMN reductase, SsuE", "go_ids": ["GO:0046306", "GO:0008752"], "go_terms": ["GO:0046306:alkanesulfonate catabolic process:P", "GO:0008752:FMN reductase [NAD(P)H] activity:F"], "name": "NADPH-dep_FMN_reduc_SsuE", "pathway_ids": ["PWY-7723"], "pathways": ["PWY-7723:t:bacterial bioluminescence"], "type": "Family"}, "IPR020049": {"description": "Major capsid protein-like", "go_ids": [], "go_terms": [], "name": "Major_capsid-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020050": {"description": "FO synthase, subunit 2", "go_ids": ["GO:0016765"], "go_terms": ["GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "FO_synthase_su2", "pathway_ids": ["PWY-8113", "PWY-8112", "PWY-5198"], "pathways": ["PWY-8113:t:3PG-factor 420 biosynthesis", "PWY-8112:t:factor 420 biosynthesis I (archaea)", "PWY-5198:t:factor 420 biosynthesis II (mycobacteria)"], "type": "Family"}, "IPR020051": {"description": "SagB-type dehydrogenase domain", "go_ids": [], "go_terms": [], "name": "SagB-type_dehydrogenase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020056": {"description": "Large ribosomal subunit protein bL25/Gln-tRNA synthetase, N-terminal", "go_ids": [], "go_terms": [], "name": "Rbsml_bL25/Gln-tRNA_synth_N", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-HSA-6782315", "R-RNO-9856649", "R-DME-9856649", "R-HSA-9856649", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M 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{"description": "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain", "go_ids": ["GO:0005524", "GO:0043039", "GO:0004812"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0043039:tRNA aminoacylation:P", "GO:0004812:aminoacyl-tRNA ligase activity:F"], "name": "Glu/Gln-tRNA-synth_Ib_cat-dom", "pathway_ids": ["PWY-5188", "R-MMU-9856649", "R-HSA-379726", "R-DDI-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-HSA-6782315", "R-RNO-9856649", "R-DME-9856649", "R-HSA-9856649", "R-HSA-379716"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR020059": {"description": "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain", "go_ids": ["GO:0000166", "GO:0004812", "GO:0005524", "GO:0005737", "GO:0006418"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0004812:aminoacyl-tRNA ligase activity:F", "GO:0005524:ATP binding:F", "GO:0005737:cytoplasm:C", "GO:0006418:tRNA aminoacylation for protein translation:P"], "name": "Glu/Gln-tRNA-synth_Ib_codon-bd", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-HSA-6782315", "R-RNO-9856649", "R-DME-9856649", "R-HSA-9856649", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR020061": {"description": "Glutamine-tRNA ligase, alpha-bundle 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"R-HSA-5578768:r:Physiological factors", "R-DME-5635838:r:Activation of SMO", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-4086398:r:Ca2+ pathway", "R-DME-209387:r:Phosphorylation of ARR", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-DME-216119:r:Activation of CI", "R-GGA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-1442490:r:Collagen degradation", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-216083:r:Integrin cell surface interactions", "R-DRE-5635838:r:Activation of SMO", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-GGA-4086398:r:Ca2+ pathway", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-4086398:r:Ca2+ pathway", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-1442490:r:Collagen degradation"], "type": "Domain"}, "IPR020069": {"description": "Large ribosomal subunit protein bL9, C-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL9_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020070": {"description": "Large ribosomal subunit protein bL9, N-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL9_N", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-DME-5389840", "R-RNO-9937383", "R-MMU-5389840", "R-HSA-5389840", "R-BTA-9937383", "R-DME-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Domain"}, "IPR020073": {"description": "Uncharacterised protein family AF1718", "go_ids": [], "go_terms": [], "name": "Uncharacterised_AF1718", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020075": {"description": "Uncharacterised protein family AF2234", "go_ids": [], "go_terms": [], "name": "Uncharacterised_AF2234", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020076": {"description": "Protein of unknown function DUF2768", "go_ids": [], "go_terms": [], "name": "DUF2768", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020077": {"description": "Protein of unknown function DUF5436", "go_ids": [], "go_terms": [], "name": "DUF5436", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020080": {"description": "Outer membrane adhesin/peptidase omptin", "go_ids": ["GO:0004190"], "go_terms": ["GO:0004190:aspartic-type endopeptidase activity:F"], "name": "OM_adhesin/peptidase_omptin", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR020085": {"description": "DNA delivery protein, P32/P34", "go_ids": ["GO:0039641"], "go_terms": ["GO:0039641:viral inner membrane:C"], "name": "DNA_delivery_prot_P32/34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020087": {"description": "Protein of unknown function DUF5487", "go_ids": [], "go_terms": [], "name": "DUF5487", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020089": {"description": "Pleiotrophin/Midkine, N-terminal domain", "go_ids": ["GO:0008083"], "go_terms": ["GO:0008083:growth factor activity:F"], "name": "PTN/MK_N_dom", "pathway_ids": ["R-RNO-201556", "R-MMU-201556", "R-XTR-2979096", "R-HSA-2979096", "R-BTA-201556", "R-SSC-9851151", "R-GGA-9851151", "R-HSA-201556", "R-RNO-9851151", "R-XTR-201556", "R-GGA-201556", "R-MMU-9851151", "R-SSC-201556", "R-BTA-9851151", "R-XTR-9851151", "R-HSA-9851151"], "pathways": ["R-RNO-201556:r:Signaling by ALK", "R-MMU-201556:r:Signaling by ALK", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-BTA-201556:r:Signaling by ALK", "R-SSC-9851151:r:MDK and PTN in ALK signaling", "R-GGA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-201556:r:Signaling by ALK", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-XTR-201556:r:Signaling by ALK", "R-GGA-201556:r:Signaling by ALK", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-SSC-201556:r:Signaling by ALK", "R-BTA-9851151:r:MDK and PTN in ALK signaling", "R-XTR-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9851151:r:MDK and PTN in ALK signaling"], "type": "Domain"}, "IPR020090": {"description": "Pleiotrophin/Midkine, C-terminal domain", "go_ids": ["GO:0008083"], "go_terms": ["GO:0008083:growth factor activity:F"], "name": "PTN/MK_C_dom", "pathway_ids": ["R-RNO-201556", "R-MMU-201556", "R-XTR-2979096", "R-HSA-2979096", "R-BTA-201556", "R-SSC-9851151", "R-GGA-9851151", "R-HSA-201556", "R-RNO-9851151", "R-XTR-201556", "R-GGA-201556", "R-MMU-9851151", "R-SSC-201556", "R-BTA-9851151", "R-XTR-9851151", "R-HSA-9851151"], "pathways": ["R-RNO-201556:r:Signaling by ALK", "R-MMU-201556:r:Signaling by ALK", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-BTA-201556:r:Signaling by ALK", "R-SSC-9851151:r:MDK and PTN in ALK signaling", "R-GGA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-201556:r:Signaling by ALK", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-XTR-201556:r:Signaling by ALK", "R-GGA-201556:r:Signaling by ALK", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-SSC-201556:r:Signaling by ALK", "R-BTA-9851151:r:MDK and PTN in ALK signaling", "R-XTR-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9851151:r:MDK and PTN in ALK signaling"], "type": "Domain"}, "IPR020091": {"description": "Pleiotrophin/Midkine disulphide-rich domain superfamily", "go_ids": ["GO:0008083"], "go_terms": ["GO:0008083:growth factor activity:F"], "name": "PTN/MK_diS_sf", "pathway_ids": ["R-RNO-201556", "R-MMU-201556", "R-XTR-2979096", "R-HSA-2979096", "R-BTA-201556", "R-SSC-9851151", "R-GGA-9851151", "R-HSA-201556", "R-RNO-9851151", "R-XTR-201556", "R-GGA-201556", "R-MMU-9851151", "R-SSC-201556", "R-BTA-9851151", "R-XTR-9851151", "R-HSA-9851151"], "pathways": ["R-RNO-201556:r:Signaling by ALK", "R-MMU-201556:r:Signaling by ALK", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-BTA-201556:r:Signaling by ALK", "R-SSC-9851151:r:MDK and PTN in ALK signaling", "R-GGA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-201556:r:Signaling by ALK", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-XTR-201556:r:Signaling by ALK", "R-GGA-201556:r:Signaling by ALK", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-SSC-201556:r:Signaling by ALK", "R-BTA-9851151:r:MDK and PTN in ALK signaling", "R-XTR-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9851151:r:MDK and PTN in ALK signaling"], "type": "Homologous_superfamily"}, "IPR020094": {"description": "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal", "go_ids": ["GO:0003723", "GO:0009982"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0009982:pseudouridine synthase activity:F"], "name": "TruA/RsuA/RluB/E/F_N", "pathway_ids": ["R-HSA-6782315", "R-HSA-6787450"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Homologous_superfamily"}, "IPR020095": {"description": "Pseudouridine synthase I, TruA, C-terminal", "go_ids": ["GO:0009982", "GO:0003723"], "go_terms": ["GO:0009982:pseudouridine synthase activity:F", "GO:0003723:RNA binding:F"], "name": "PsdUridine_synth_TruA_C", "pathway_ids": ["R-HSA-6782315", "R-HSA-6787450"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Homologous_superfamily"}, "IPR020097": {"description": "Pseudouridine synthase I, TruA, alpha/beta domain", "go_ids": ["GO:0001522", "GO:0003723", "GO:0009451", "GO:0009982"], "go_terms": ["GO:0001522:pseudouridine synthesis:P", "GO:0003723:RNA binding:F", "GO:0009451:RNA modification:P", "GO:0009982:pseudouridine synthase activity:F"], "name": "PsdUridine_synth_TruA_a/b_dom", "pathway_ids": ["R-HSA-6782315", "R-HSA-6787450"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR020099": {"description": "Protein of unknown function DUF5445", "go_ids": [], "go_terms": [], "name": "DUF5445", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020100": {"description": "Glucose-repressible protein Grg1", "go_ids": [], "go_terms": [], "name": "Glc-repressible_Grg1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020101": {"description": "Cytochrome b-c1 complex subunit 8, plants", "go_ids": ["GO:0098803"], "go_terms": ["GO:0098803:respiratory chain complex:C"], "name": "Cyt_b-c1_8-plants", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020102": {"description": "Uncharacterised protein YqgC-like", "go_ids": [], "go_terms": [], "name": "YqgC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020103": {"description": "Pseudouridine synthase, catalytic domain superfamily", "go_ids": ["GO:0001522", "GO:0003723", "GO:0009451", "GO:0009982"], "go_terms": ["GO:0001522:pseudouridine synthesis:P", "GO:0003723:RNA binding:F", "GO:0009451:RNA modification:P", "GO:0009982:pseudouridine synthase activity:F"], "name": "PsdUridine_synth_cat_dom_sf", "pathway_ids": ["R-HSA-6787450", "R-HSA-9937008", "R-HSA-6793080", "R-CEL-171319", "R-SPO-171319", "R-HSA-6782315", "R-GGA-417076", "R-DME-171319", "R-SCE-171319", "R-DRE-171319", "R-RNO-171319", "R-DDI-171319", "R-HSA-6790901", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-CEL-171319:r:Telomere Extension By Telomerase", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-GGA-417076:r:Assembly of telomerase and telomere extension", "R-DME-171319:r:Telomere Extension By Telomerase", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DDI-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Homologous_superfamily"}, "IPR020104": {"description": "Protein of unknown function DUF5438", "go_ids": [], "go_terms": [], "name": "DUF5438", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020108": {"description": "Spore coat protein CotD", "go_ids": [], "go_terms": [], "name": "Spore_coat_CotD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020109": {"description": "Holin, r1t-type", "go_ids": [], "go_terms": [], "name": "Holin_r1t", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020112": {"description": "Protein of unknown function DUF2883", "go_ids": [], "go_terms": [], "name": "DUF2883", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020113": {"description": "Protein of unknown function DUF5439", "go_ids": [], "go_terms": [], "name": "DUF5439", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020115": {"description": "Anti-sigma-F factor Fin", "go_ids": ["GO:0010468"], "go_terms": ["GO:0010468:regulation of gene expression:P"], "name": "Fin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020117": {"description": "Uncharacterised protein family YncJ", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YncJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020120": {"description": "Plasmid pGKL2, Orf8", "go_ids": [], "go_terms": [], "name": "Plasmid_pGKL2_Orf8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020121": {"description": "Bacteriophage T7-like gene 6.5", "go_ids": [], "go_terms": [], "name": "Phage_T7-like_6.5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020122": {"description": "Alphabaculovirus, Y056", "go_ids": [], "go_terms": [], "name": "Alphabaculovirus_Y056", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020123": {"description": "Protein of unknown function DUF5475", "go_ids": [], "go_terms": [], "name": "DUF5475", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020125": {"description": "Protein of unknown function DUF5488", "go_ids": [], "go_terms": [], "name": "DUF5488", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020126": {"description": "Protein of unknown function DUF2732", "go_ids": [], "go_terms": [], "name": "DUF2732", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020127": {"description": "Colicin-E5 immunity protein", "go_ids": ["GO:0030153"], "go_terms": ["GO:0030153:bacteriocin immunity:P"], "name": "Colicin-E5_imm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020128": {"description": "Secapin", "go_ids": [], "go_terms": [], "name": "Secapin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020130": {"description": "Spanin, outer lipoprotein subunit, T7likevirus", "go_ids": ["GO:0019076"], "go_terms": ["GO:0019076:viral release from host cell:P"], "name": "O-spanin_T7likevirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020132": {"description": "Mycobacteriophage tail assembly protein 24/25", "go_ids": [], "go_terms": [], "name": "Gp24/Gp25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020133": {"description": "Decidual protein, progesterone induced", "go_ids": [], "go_terms": [], "name": "DEPP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020134": {"description": "Bacteriophage T7-like, protein 6.7", "go_ids": [], "go_terms": [], "name": "Phage_T7-like_6.7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020135": {"description": "Uncharacterised protein family RP854", "go_ids": [], "go_terms": [], "name": "Uncharacterised_RP854", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020138": {"description": "Uncharacterised protein family YqzF", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YqzF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020139": {"description": "Protein of unknown function DUF2642", "go_ids": [], "go_terms": [], "name": "DUF2642", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020140": {"description": "Uncharacterised protein family YusG", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YusG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020141": {"description": "Cytomegalovirus UL41A", "go_ids": [], "go_terms": [], "name": "Cytomegalovirus_UL41A", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR020142": {"description": "Protein of unknown function DUF5489", "go_ids": [], "go_terms": [], "name": "DUF5489", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020144": {"description": "Stage V sporulation protein AB", "go_ids": [], "go_terms": [], "name": "SpoVAB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020147": {"description": "Inhibitor of dGTPase, bacteriophage T7-like", "go_ids": [], "go_terms": [], "name": "Phage_T7-like_1.2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020148": {"description": "Protein of unknown function DUF5477", "go_ids": [], "go_terms": [], "name": "DUF5477", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020149": {"description": "Uncharacterised protein family C02F5.10", "go_ids": [], "go_terms": [], "name": "Uncharacterised_C02F5.10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020150": {"description": "Type IV conjugative transfer system protein TrbE", "go_ids": [], "go_terms": [], "name": "T4SS_TrbE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020151": {"description": "Protein of unknown function DUF5478", "go_ids": [], "go_terms": [], "name": "DUF5478", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020155": {"description": "Uncharacterised protein family YeiS", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Uncharacterised_YeiS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020156": {"description": "Protein of unknown function DUF5490", "go_ids": [], "go_terms": [], "name": "DUF5490", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020157": {"description": "Uncharacterised protein family YqkC", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YqkC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020158": {"description": "Protein of unknown function DUF2756", "go_ids": [], "go_terms": [], "name": "DUF2756", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020159": {"description": "Tail fiber assembly helper protein", "go_ids": [], "go_terms": [], "name": "Gp57", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020162": {"description": "Cell cycle exit/neuronal differentiation protein 1", "go_ids": ["GO:0030182", "GO:0021549"], "go_terms": ["GO:0030182:neuron differentiation:P", "GO:0021549:cerebellum development:P"], "name": "Cend1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020164": {"description": "Cytochrome c oxidase assembly protein COX16", "go_ids": ["GO:0031966"], "go_terms": ["GO:0031966:mitochondrial membrane:C"], "name": "Cyt_c_Oxase_assmbl_COX16", "pathway_ids": ["R-MMU-9864848", "R-HSA-9864848", "R-CEL-9864848", "R-BTA-9864848"], "pathways": ["R-MMU-9864848:r:Complex IV assembly", "R-HSA-9864848:r:Complex IV assembly", "R-CEL-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR020168": {"description": "Uncharacterised protein family RP363/RP364", "go_ids": [], "go_terms": [], "name": "Uncharacterised_RP363/RP364", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020169": {"description": "Intrinsic membrane protein family, PufX", "go_ids": [], "go_terms": [], "name": "Intrinsic_membrane_PufX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020170": {"description": "Herpesvirus UL11, muromegalovirus/roseolovirus-type", "go_ids": [], "go_terms": [], "name": "Herpes_UL11_megaloV/roseoloV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020171": {"description": "Uncharacterised protein family RC0039", "go_ids": [], "go_terms": [], "name": "Uncharacterised_RC0039", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020175": {"description": "Herpesvirus glycoprotein L, rhadinovirus-type", "go_ids": ["GO:0019064"], "go_terms": ["GO:0019064:fusion of virus membrane with host plasma membrane:P"], "name": "Herpes_gL_rhadinovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020180": {"description": "Uncharacterised protein family RP853", "go_ids": [], "go_terms": [], "name": "Uncharacterised_RP853", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020182": {"description": "Protein of unknown function DUF5460", "go_ids": [], "go_terms": [], "name": "DUF5460", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020183": {"description": "Uncharacterised protein family RC0048", "go_ids": [], "go_terms": [], "name": "Uncharacterised_RC0048", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020184": {"description": "Keratin-associated protein 7", "go_ids": [], "go_terms": [], "name": "KRTAP7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020185": {"description": "Spore morphogenesis/germination protein YwcE", "go_ids": [], "go_terms": [], "name": "Spore_morphogenesis_YwcE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020186": {"description": "Meiosis-expressed gene 1 protein", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "Meiosis-expressed_gene_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020189": {"description": "Translation initiation factor 5A, C-terminal", "go_ids": ["GO:0003723", "GO:0043022"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0043022:ribosome binding:F"], "name": "IF5A_C", "pathway_ids": ["R-RNO-204626", "R-MMU-204626", "R-HSA-204626", "R-CEL-204626", "R-DRE-204626", "R-DDI-204626", "R-DME-204626", "R-SCE-204626", "R-GGA-204626", "R-SPO-204626", "R-BTA-204626"], "pathways": ["R-RNO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DRE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DDI-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DME-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SCE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-GGA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-BTA-204626:r:Hypusine synthesis from eIF5A-lysine"], "type": "Domain"}, "IPR020190": {"description": "Procorazonin", "go_ids": ["GO:0071858", "GO:0045823"], "go_terms": ["GO:0071858:corazonin receptor binding:F", "GO:0045823:positive regulation of heart contraction:P"], "name": "Procorazonin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020195": {"description": "SWR1 chromatin-remodelling complex, subunit Swc7", "go_ids": [], "go_terms": [], "name": "SWR1_Swc7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020196": {"description": "Uncharacterised protein family YqgB", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YqgB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020201": {"description": "Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf52", "go_ids": [], "go_terms": [], "name": "AcMNPV_Orf52", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020202": {"description": "Atracotoxin", "go_ids": [], "go_terms": [], "name": "Atracotoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020203": {"description": "Membrane protein YneK", "go_ids": [], "go_terms": [], "name": "YneK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020204": {"description": "Uncharacterised protein family, YxaJ", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YxaJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020205": {"description": "Uncharacterised protein family, YwnF, transmembrane", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YwnF_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020206": {"description": "Uncharacterised protein family, VP2110", "go_ids": [], "go_terms": [], "name": "Uncharacterised_VP2110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020207": {"description": "Metastasis-suppressor KiSS-1", "go_ids": [], "go_terms": [], "name": "Metastasis-suppressor_KiSS-1", "pathway_ids": ["R-MMU-416476", "R-RNO-416476", "R-HSA-416476", "R-MMU-375276", "R-RNO-375276", "R-HSA-375276"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors"], "type": "Family"}, "IPR020208": {"description": "Protein of unknown function DUF2712", "go_ids": [], "go_terms": [], "name": "DUF2712", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020209": {"description": "Cas6b, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cas6b_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020210": {"description": "Uncharacterised protein family, YpbF, transmembrane", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YpbF_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020213": {"description": "Toxin coregulated pilus biosynthesis protein TcpS", "go_ids": [], "go_terms": [], "name": "Toxin-coreg_pilus_synth_TcpS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020214": {"description": "Cytomegalovirus UL124", "go_ids": [], "go_terms": [], "name": "Cytomega_UL124", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR020215": {"description": "EbsA-like", "go_ids": [], "go_terms": [], "name": "EbsA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020216": {"description": "Uncharacterised protein family, YncE", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YncE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020221": {"description": "Protein of unknown function DUF5505", "go_ids": [], "go_terms": [], "name": "DUF5505", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020226": {"description": "Avian adenovirus Orf17", "go_ids": [], "go_terms": [], "name": "Avian_adenovirus_Orf17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020230": {"description": "Transcription regulator MotB", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_MotB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020231": {"description": "Uncharacterised protein family, YfgI", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YfgI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020233": {"description": "GSE/EGO complex subunit Slm4", "go_ids": ["GO:0071986", "GO:0007165"], "go_terms": ["GO:0071986:Ragulator complex:C", "GO:0007165:signal transduction:P"], "name": "Slm4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020234": {"description": "Mite allergen, group-7", "go_ids": [], "go_terms": [], "name": "Mite_allergen_group-7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020239": {"description": "Protein of unknown function DUF5511", "go_ids": [], "go_terms": [], "name": "DUF5511", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020240": {"description": "Uncharacterised protein family UPF0412, YaaI", "go_ids": [], "go_terms": [], "name": "UPF0412_YaaI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020241": {"description": "Ribonuclease P/MRP subunit Pop7, fungi", "go_ids": ["GO:0000172", "GO:0005655", "GO:0001682", "GO:0006396"], "go_terms": ["GO:0000172:ribonuclease MRP complex:C", "GO:0005655:nucleolar ribonuclease P complex:C", "GO:0001682:tRNA 5'-leader removal:P", "GO:0006396:RNA processing:P"], "name": "RNase_P/MRP_Pop7_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020242": {"description": "Conotoxin I2", "go_ids": [], "go_terms": [], "name": "Conotoxin_I2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020244": {"description": "Rotavirus B, non-structural protein 5", "go_ids": [], "go_terms": [], "name": "Rotavirus_B_NSP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020246": {"description": "Uncharacterised protein family SCO3924", "go_ids": [], "go_terms": [], "name": "Uncharacterised_SCO3924", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020248": {"description": "MobB-Gp55", "go_ids": [], "go_terms": [], "name": "MobB-Gp55", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020249": {"description": "Protein of unknown function DUF5492", "go_ids": [], "go_terms": [], "name": "DUF5492", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020250": {"description": "Uncharacterised protein family, plasmid pXO2-72", "go_ids": [], "go_terms": [], "name": "Plasmid_pXO2-72", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020251": {"description": "Uncharacterised protein family, YmjA", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YmjA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020252": {"description": "Protein of unknown function DUF5446", "go_ids": [], "go_terms": [], "name": "DUF5446", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020253": {"description": "Torovirus, nucleocapsid protein", "go_ids": [], "go_terms": [], "name": "Torovirus_nucleocapsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020254": {"description": "Protein of unknown function DUF2626", "go_ids": [], "go_terms": [], "name": "DUF2626", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020255": {"description": "Minor curli fiber component A", "go_ids": [], "go_terms": [], "name": "CsgA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020256": {"description": "Spore coat protein CotJA", "go_ids": [], "go_terms": [], "name": "Spore_coat_CotJA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020257": {"description": "Protein of unknown function DUF5512", "go_ids": [], "go_terms": [], "name": "DUF5512", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020258": {"description": "Uncharacterised protein family YbeF", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YbeF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020260": {"description": "Uncharacterised protein family YueH", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YueH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020261": {"description": "Protein of unknown function DUF5493", "go_ids": [], "go_terms": [], "name": "DUF5493", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020262": {"description": "Uncharacterised protein family YecJ", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YecJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020265": {"description": "Protein of unknown function DUF5513", "go_ids": [], "go_terms": [], "name": "DUF5513", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020266": {"description": "Mitochondrial import receptor subunit Tom6", "go_ids": ["GO:0005742", "GO:0030150"], "go_terms": ["GO:0005742:mitochondrial outer membrane translocase complex:C", "GO:0030150:protein import into mitochondrial matrix:P"], "name": "Tom6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020269": {"description": "Releasin protein, Bacteriophage Mu", "go_ids": [], "go_terms": [], "name": "Phage_Mu_Releasin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020270": {"description": "Uncharacterised protein family, plasmid pXO2-34", "go_ids": [], "go_terms": [], "name": "Plasmid_pXO2-34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020271": {"description": "Uncharacterised protein family, MJ1172", "go_ids": [], "go_terms": [], "name": "Uncharacterised_MJ1172", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020272": {"description": "Uncharacterized protein C-84-like", "go_ids": [], "go_terms": [], "name": "C-84-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020274": {"description": "Uncharacterised protein family HI1496", "go_ids": [], "go_terms": [], "name": "Uncharacterised_HI1496", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020275": {"description": "Protein of unknown function DUF5592", "go_ids": [], "go_terms": [], "name": "DUF5592", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020277": {"description": "Protein of unknown function DUF2624", "go_ids": [], "go_terms": [], "name": "DUF2624", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020278": {"description": "Small protein YqaH-like", "go_ids": [], "go_terms": [], "name": "YqaH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020280": {"description": "Microcin V bacteriocin", "go_ids": [], "go_terms": [], "name": "MccV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020282": {"description": "Arginine vasopressin-induced protein 1/transcriptional and immune response regulator", "go_ids": [], "go_terms": [], "name": "Avpi1/C8orf4_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020285": {"description": "Superinfection exclusion gene product 17", "go_ids": [], "go_terms": [], "name": "Gp17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020287": {"description": "Tail sheath protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tail_sheath_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020288": {"description": "Contractile injection system sheath initiator", "go_ids": [], "go_terms": [], "name": "Sheath_initiator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020290": {"description": "Gene product 88", "go_ids": [], "go_terms": [], "name": "Gp88", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020293": {"description": "Accessory recombination function protein", "go_ids": [], "go_terms": [], "name": "Arf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020295": {"description": "Protein of unknown function DUF2737", "go_ids": [], "go_terms": [], "name": "DUF2737", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020296": {"description": "Sporulation protein Cse60", "go_ids": [], "go_terms": [], "name": "Spore_Cse60", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020298": {"description": "Kil protein, bacteriophage P22-type", "go_ids": [], "go_terms": [], "name": "Kil_phage_P22-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020300": {"description": "Protein of unknown function DUF2644", "go_ids": [], "go_terms": [], "name": "DUF2644", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020301": {"description": "MIOREX complex component 7", "go_ids": [], "go_terms": [], "name": "Mrx7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020302": {"description": "Uncharacterized YnfE-like", "go_ids": [], "go_terms": [], "name": "YnfE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020303": {"description": "Protein of unknown function DUF5495", "go_ids": [], "go_terms": [], "name": "DUF5495", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020306": {"description": "Mite allergen, group 5/21", "go_ids": [], "go_terms": [], "name": "Mite_allergen_group-5/21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020308": {"description": "Uncharacterised protein family, Ynq1", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ynq1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020309": {"description": "Small integral membrane protein 14", "go_ids": [], "go_terms": [], "name": "Smim-14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020311": {"description": "Uncharacterised protein family, Rv0898c", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Rv0898c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020312": {"description": "Protein of unknown function DUF5497", "go_ids": [], "go_terms": [], "name": "DUF5497", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020313": {"description": "Double-stranded DNA-binding protein", "go_ids": [], "go_terms": [], "name": "Double-stranded_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020314": {"description": "Uncharacterised protein family YpzA", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YpzA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020317": {"description": "Uncharacterised protein family YjbD", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YjbD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020320": {"description": "Swinepox virus, C2", "go_ids": [], "go_terms": [], "name": "Swinepox_virus_C2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020323": {"description": "Protein of unknown function DUF2716", "go_ids": [], "go_terms": [], "name": "DUF2716", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020325": {"description": "Uncharacterised protein family 16.1kDa", "go_ids": [], "go_terms": [], "name": "Uncharacterised_16.1kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020335": {"description": "Probable scaffold protein Gp13, bacteriophage T7", "go_ids": [], "go_terms": [], "name": "Phage_T7_Gp13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020338": {"description": "SMN complex, gem-associated protein 7", "go_ids": ["GO:0034719"], "go_terms": ["GO:0034719:SMN-Sm protein complex:C"], "name": "SMN_gemin7", "pathway_ids": ["R-BTA-191859", "R-MMU-191859", "R-HSA-9754678", "R-HSA-191859"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-MMU-191859:r:snRNP Assembly", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-191859:r:snRNP Assembly"], "type": "Family"}, "IPR020339": {"description": "Ciliary microtubule inner protein 1-like", "go_ids": [], "go_terms": [], "name": "C20orf85-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020342": {"description": "Bacteriophage T4, Gp16, DNA-packaging", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp16_DNA-pack", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020343": {"description": "Viral CC chemokine-like protein FPV060", "go_ids": [], "go_terms": [], "name": "Chemokine_CC_FPV060", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020346": {"description": "Uncharacterised protein family 15.3kDa", "go_ids": [], "go_terms": [], "name": "Uncharacterised_15.3kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020347": {"description": "Ribonucleases P/MRP protein subunit Pop8", "go_ids": ["GO:0008033", "GO:0000172", "GO:0005655"], "go_terms": ["GO:0008033:tRNA processing:P", "GO:0000172:ribonuclease MRP complex:C", "GO:0005655:nucleolar ribonuclease P complex:C"], "name": "Pop8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020348": {"description": "Uncharacterised protein family YvaD", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YvaD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020349": {"description": "Uncharacterised protein family 14.7kDa", "go_ids": [], "go_terms": [], "name": "Uncharacterised_14.7kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020350": {"description": "Chemokine-like protein TAFA", "go_ids": [], "go_terms": [], "name": "Chemokine-like_TAFA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020351": {"description": "Phage tail assemb.y chaperone protein, TAC", "go_ids": [], "go_terms": [], "name": "Phage_TAC_9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020353": {"description": "mRNA interferase toxin YafO", "go_ids": [], "go_terms": [], "name": "Toxin_YafO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020354": {"description": "Competence, DNA-entry nuclease inhibitor, ComJ", "go_ids": [], "go_terms": [], "name": "Competence_nuclease_inhibitor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020355": {"description": "Uncharacterised protein family YhcU", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YhcU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020356": {"description": "Poxvirus T3C", "go_ids": [], "go_terms": [], "name": "Poxvirus_T3C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020357": {"description": "Transcription regulator CaiF/GrlA", "go_ids": ["GO:0006351"], "go_terms": ["GO:0006351:DNA-templated transcription:P"], "name": "Tscrpt_reg_CaiF/GrlA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020359": {"description": "Biofilm regulator BssR", "go_ids": [], "go_terms": [], "name": "Biofilm_regulator_BssR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020360": {"description": "Uncharacterised protein family alr2393", "go_ids": [], "go_terms": [], "name": "Uncharacterised_alr2393", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020362": {"description": "Tail accessory factor GP4", "go_ids": [], "go_terms": [], "name": "Tail_accessory_Gp4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020363": {"description": "Uncharacterised protein family YbgS", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YbgS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020366": {"description": "INO80 complex subunit Ies5", "go_ids": ["GO:0031011"], "go_terms": ["GO:0031011:Ino80 complex:C"], "name": "Ies5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020367": {"description": "Host transcription inhibitor Alc", "go_ids": ["GO:0039653"], "go_terms": ["GO:0039653:symbiont-mediated suppression of host transcription:P"], "name": "Host_transcript_inhib_Alc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020368": {"description": "Uncharacterised protein family YbjM", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Uncharacterised_YbjM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020369": {"description": "Mobilisation protein B", "go_ids": [], "go_terms": [], "name": "Mobilisation_protein_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020372": {"description": "Competence operon G protein 7, ComGG", "go_ids": [], "go_terms": [], "name": "Competence_ComGG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020373": {"description": "Alpha-ketoglutarate dehydrogenase component 4/YMR-31", "go_ids": ["GO:0006103"], "go_terms": ["GO:0006103:2-oxoglutarate metabolic process:P"], "name": "Kgd4/YMR-31", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-SCE-9853506", "R-MMU-6783984", "R-SPO-9853506", "R-HSA-9853506", "R-SCE-6783984", "R-HSA-9937383", "R-BTA-9937383", "R-BTA-5389840", "R-BTA-6783984", "R-HSA-5368286", "R-HSA-6783984", "R-MMU-5419276", "R-BTA-5419276", "R-SPO-6783984", "R-HSA-5389840", "R-MMU-9853506", "R-MMU-5389840", "R-BTA-9853506"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-6783984:r:Glycine degradation", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SCE-6783984:r:Glycine degradation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-BTA-6783984:r:Glycine degradation", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-HSA-6783984:r:Glycine degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-SPO-6783984:r:Glycine degradation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG"], "type": "Family"}, "IPR020376": {"description": "Uncharacterised protein family F46C5.1", "go_ids": [], "go_terms": [], "name": "Uncharacterised_F46C5.1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020377": {"description": "Uncharacterised protein family LpqV", "go_ids": [], "go_terms": [], "name": "Uncharacterised_LpqV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020378": {"description": "Protein of unknown function DUF4186", "go_ids": [], "go_terms": [], "name": "DUF4186", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020379": {"description": "Protein of unknown function DUF5448", "go_ids": [], "go_terms": [], "name": "DUF5448", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020380": {"description": "Uncharacterised protein family MJ1658", "go_ids": [], "go_terms": [], "name": "Uncharacterised_MJ1658", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020382": {"description": "Androgenic gland hormone", "go_ids": [], "go_terms": [], "name": "AGH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020383": {"description": "MinK-related peptide, potassium channel accessory subunit protein 4", "go_ids": [], "go_terms": [], "name": "MPS4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020386": {"description": "Uncharacterised protein family YehE", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YehE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020387": {"description": "Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf112", "go_ids": [], "go_terms": [], "name": "AcMNPV_Orf112", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020390": {"description": "Uncharacterised protein family YqhV", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YqhV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020393": {"description": "Uncharacterised protein family YusU", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YusU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020394": {"description": "Uncharacterised protein family, FAM23-like, transmembrane", "go_ids": [], "go_terms": [], "name": "Uncharacterised_FAM23-like_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020399": {"description": "T-cell receptor-associated transmembrane adapter 1", "go_ids": [], "go_terms": [], "name": "T-cell_rcpt-assoc_TM_adapter-1", "pathway_ids": ["R-MMU-1257604", "R-HSA-2219530", "R-HSA-1257604", "R-HSA-202424", "R-MMU-6811558", "R-MMU-202424", "R-HSA-6811558"], "pathways": ["R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "type": "Family"}, "IPR020400": {"description": "Cecropin/Sarcotoxins/Aedesins", "go_ids": ["GO:0019731", "GO:0005576"], "go_terms": ["GO:0019731:antibacterial humoral response:P", "GO:0005576:extracellular region:C"], "name": "CecC/Srx/CECD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020401": {"description": "mRNA transport factor GFD1", "go_ids": [], "go_terms": [], "name": "mRNA_transport_factor_GFD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020403": {"description": "Equine arteritis virus envelope glycoprotein 5", "go_ids": [], "go_terms": [], "name": "EAV_Gp5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020404": {"description": "Protein of unknown function DUF2713", "go_ids": [], "go_terms": [], "name": "DUF2713", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020405": {"description": "Atypical dual specificity phosphatase, subfamily A", "go_ids": ["GO:0006470", "GO:0008138"], "go_terms": ["GO:0006470:protein dephosphorylation:P", "GO:0008138:protein tyrosine/serine/threonine phosphatase activity:F"], "name": "Atypical_DUSP_subfamA", "pathway_ids": ["R-MMU-202670", "R-HSA-202670"], "pathways": ["R-MMU-202670:r:ERKs are inactivated", "R-HSA-202670:r:ERKs are inactivated"], "type": "Family"}, "IPR020408": {"description": "Nerve growth factor-like", "go_ids": [], "go_terms": [], "name": "Nerve_growth_factor-like", "pathway_ids": ["R-HSA-9022702", "R-GGA-9032759", "R-HSA-187042", "R-MMU-6811558", "R-HSA-9026357", "R-HSA-167021", "R-HSA-198745", "R-RNO-187042", "R-HSA-9026519", "R-SSC-6811558", "R-RNO-198203", "R-RNO-6811558", "R-BTA-6811558", "R-HSA-9603381", "R-MMU-187042", "R-RNO-170968", "R-RNO-205043", "R-RNO-177504", "R-DRE-209563", "R-RNO-9034013", "R-RNO-9026527", "R-HSA-170984", "R-DRE-170984", "R-HSA-9026527", "R-HSA-209560", "R-HSA-193670", "R-MMU-209543", "R-MMU-170968", "R-HSA-205043", "R-HSA-9034793", "R-RNO-209560", "R-RNO-205025", "R-HSA-9024909", "R-DRE-167060", "R-BTA-9028731", "R-HSA-2219530", "R-SSC-9032759", "R-RNO-209563", "R-RNO-209543", "R-HSA-209563", "R-SSC-9028731", "R-HSA-6811558", "R-DRE-209543", "R-HSA-167060", "R-MMU-170984", "R-HSA-1257604", "R-MMU-9034013", "R-RNO-9028731", "R-DRE-198203", "R-HSA-198203", "R-HSA-9768919", "R-SSC-1257604", "R-MMU-205017", "R-BTA-9603381", "R-HSA-205017", "R-HSA-167044", "R-HSA-9034015", "R-HSA-209543", "R-RNO-1257604", "R-DRE-205017", "R-BTA-9026527", "R-MMU-205025", "R-HSA-9032759", "R-MMU-9034793", "R-MMU-198203", "R-HSA-9028335", "R-GGA-6811558", "R-GGA-9028731", "R-DRE-209560", "R-RNO-205017", "R-MMU-167060", "R-SSC-9026527", "R-RNO-170984", "R-MMU-205043", "R-HSA-9032845", "R-HSA-9025046", "R-BTA-9034793", "R-HSA-9028731", "R-GGA-1257604", "R-DRE-187042", "R-MMU-9603381", "R-HSA-193648", "R-MMU-209560", "R-RNO-9034793", "R-RNO-9603381", "R-MMU-9028731", "R-HSA-9034864", "R-DRE-170968", "R-MMU-1257604", "R-HSA-9032500", "R-DRE-177504", "R-MMU-209563", "R-HSA-177504", "R-HSA-193681", "R-HSA-9034013", "R-RNO-9032759", "R-HSA-187706", "R-MMU-177504", "R-HSA-170968", "R-RNO-167060", "R-MMU-9032759", "R-HSA-205025", "R-BTA-1257604", "R-BTA-9034013", "R-GGA-9026527", "R-MMU-9026527"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-GGA-9032759:r:NTRK2 activates RAC1", "R-HSA-187042:r:TRKA activation by NGF", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-HSA-198745:r:Signalling to STAT3", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-187042:r:TRKA activation by NGF", "R-RNO-170968:r:Frs2-mediated activation", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DRE-209563:r:Axonal growth stimulation", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-170984:r:ARMS-mediated activation", "R-DRE-170984:r:ARMS-mediated activation", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-HSA-193670:r:p75NTR negatively regulates cell cycle via SC1", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-DRE-167060:r:NGF processing", "R-BTA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-RNO-209563:r:Axonal growth stimulation", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-209563:r:Axonal growth stimulation", "R-SSC-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-HSA-167060:r:NGF processing", "R-MMU-170984:r:ARMS-mediated activation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DRE-198203:r:PI3K/AKT activation", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-MMU-205017:r:NFG and proNGF binds to p75NTR", "R-BTA-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-205017:r:NFG and proNGF binds to p75NTR", "R-HSA-167044:r:Signalling to RAS", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DRE-205017:r:NFG and proNGF binds to p75NTR", "R-BTA-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-205025:r:NADE modulates death signalling", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DRE-209560:r:NF-kB is activated and signals survival", "R-RNO-205017:r:NFG and proNGF binds to p75NTR", "R-MMU-167060:r:NGF processing", "R-SSC-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-170984:r:ARMS-mediated activation", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-BTA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-DRE-187042:r:TRKA activation by NGF", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-DRE-170968:r:Frs2-mediated activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-DRE-177504:r:Retrograde neurotrophin signalling", "R-MMU-209563:r:Axonal growth stimulation", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-193681:r:Ceramide signalling", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-HSA-170968:r:Frs2-mediated activation", "R-RNO-167060:r:NGF processing", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-HSA-205025:r:NADE modulates death signalling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-BTA-9034013:r:NTF3 activates NTRK3 signaling", "R-GGA-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1"], "type": "Family"}, "IPR020415": {"description": "Interleukin-34", "go_ids": ["GO:0001934", "GO:0005157", "GO:0005576", "GO:0008284"], "go_terms": ["GO:0001934:positive regulation of protein phosphorylation:P", "GO:0005157:macrophage colony-stimulating factor receptor binding:F", "GO:0005576:extracellular region:C", "GO:0008284:positive regulation of cell population proliferation:P"], "name": "IL-34", "pathway_ids": ["R-HSA-449836", "R-BTA-449836", "R-RNO-449836", "R-HSA-9680350", "R-MMU-449836"], "pathways": ["R-HSA-449836:r:Other interleukin signaling", "R-BTA-449836:r:Other interleukin signaling", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-449836:r:Other interleukin signaling"], "type": "Family"}, "IPR020422": {"description": "Dual specificity protein phosphatase domain", "go_ids": ["GO:0006470"], "go_terms": ["GO:0006470:protein dephosphorylation:P"], "name": "TYR_PHOSPHATASE_DUAL_dom", "pathway_ids": ["R-DDI-8873719", "R-BTA-202670", "R-HSA-8873719", "R-SPO-5687128", "R-HSA-3785653", "R-HSA-72086", "R-CEL-72086", "R-CEL-202670", "R-HSA-1483148", "R-DRE-77075", "R-DRE-176407", "R-MMU-112409", "R-HSA-3322077", "R-CEL-112409", "R-DDI-112409", "R-SPO-176407", "R-HSA-77075", "R-SCE-176407", "R-HSA-176407", "R-MMU-202670", "R-DME-112409", "R-DRE-5687128", "R-GGA-437980", "R-HSA-202670", "R-CEL-5675221", "R-DME-8873719", "R-DRE-72086", "R-SCE-202670", "R-BTA-112409", "R-RNO-5675221", "R-DME-202670", "R-CEL-77075", "R-DDI-5675221", "R-RNO-112409", "R-HSA-9636569", "R-DDI-202670", "R-CEL-176407", "R-MMU-8873719", "R-BTA-5675221", "R-RNO-202670", "R-MMU-176407", "R-DME-5675221", "R-HSA-9652817", "R-HSA-5687128", "R-MMU-77075", "R-HSA-112409", "R-RNO-8873719", "R-HSA-167160", "R-SPO-202670", "R-MMU-72086", "R-MMU-5687128", "R-SCE-5687128", "R-GGA-437986", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-DDI-8873719:r:RAB geranylgeranylation", "R-BTA-202670:r:ERKs are inactivated", "R-HSA-8873719:r:RAB geranylgeranylation", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-HSA-72086:r:mRNA Capping", "R-CEL-72086:r:mRNA Capping", "R-CEL-202670:r:ERKs are inactivated", "R-HSA-1483148:r:Synthesis of PG", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DRE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-112409:r:RAF-independent MAPK1/3 activation", "R-HSA-3322077:r:Glycogen synthesis", "R-CEL-112409:r:RAF-independent MAPK1/3 activation", 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"R-SSC-416476", "R-BTA-375276", "R-BTA-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-CFA-375276:r:Peptide ligand-binding receptors", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-CFA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-SSC-416476:r:G alpha (q) signalling events", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-BTA-416476:r:G alpha (q) signalling events"], "type": "Family"}, "IPR020481": {"description": "Intracellular proteinase inhibitor BsuPI", "go_ids": [], "go_terms": [], "name": "Intracell_prot_inh_BsuPI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020483": {"description": "Uncharacterised protein family YgbA", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YgbA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020484": {"description": "Protein of unknown function DUF5503", "go_ids": [], "go_terms": [], "name": "DUF5503", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020485": {"description": "Stationary phase protein 4", "go_ids": [], "go_terms": [], "name": "Spg4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020489": {"description": "Uncharacterised protein family YejG", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YejG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020490": {"description": "Uncharacterised protein family YaiZ", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YaiZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020491": {"description": "Biogenesis of lysosome-related organelles complex 1 subunit BLI1", "go_ids": [], "go_terms": [], "name": "BLI1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020493": {"description": "Uncharacterised protein family HI0310", "go_ids": [], "go_terms": [], "name": "Uncharacterised_HI0310", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020496": {"description": "Sigma-M inhibitor YhdK", "go_ids": [], "go_terms": [], "name": "YhdK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020497": {"description": "Protein of unknown function DUF5440", "go_ids": [], "go_terms": [], "name": "DUF5440", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020500": {"description": "Anti-RecBCD protein 2, bacteriophage P22", "go_ids": [], "go_terms": [], "name": "Phage_P22_anti-RecBCD_p2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020501": {"description": "Uncharacterised protein family AF1218", "go_ids": [], "go_terms": [], "name": "Uncharacterised_AF1218", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020502": {"description": "Late transcription unit B", "go_ids": [], "go_terms": [], "name": "LtuB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020503": {"description": "Uncharacterised protein family Rv2561", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Rv2561", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020504": {"description": "Protein of unknown function DUF5500", "go_ids": [], "go_terms": [], "name": "DUF5500", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020507": {"description": "Protein of unknown function DUF5517", "go_ids": [], "go_terms": [], "name": "DUF5517", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020508": {"description": "SecA translation cis-regulator SecM, small type", "go_ids": [], "go_terms": [], "name": "SecM_small", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020509": {"description": "Uncharacterised protein family YnzE", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YnzE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020510": {"description": "Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD", "go_ids": [], "go_terms": [], "name": "IcaD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020511": {"description": "Uncharacterised protein family HI0941", "go_ids": [], "go_terms": [], "name": "Uncharacterised_HI0941", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020513": {"description": "Uncharacterised protein family, inner membrane YaiY", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Uncharacterised_IM_YaiY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020516": {"description": "Uncharacterised protein family YxcD", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YxcD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020518": {"description": "Transcription regulator PrtN", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Tscrpt_reg_PrtN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020519": {"description": "Divergent protein kinase domain 2A/B", "go_ids": [], "go_terms": [], "name": "DIPK2A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020526": {"description": "Large ribosomal subunit protein cL38", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412", "GO:0009507", "GO:0019843"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P", "GO:0009507:chloroplast:C", "GO:0019843:rRNA binding:F"], "name": "Ribosomal_cL38", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020527": {"description": "UL17, Cytomegalovirus", "go_ids": [], "go_terms": [], "name": "UL17_Cytomegalovir", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR020529": {"description": "Origin recognition complex, subunit 6, metazoa/plant", "go_ids": ["GO:0005664", "GO:0006260"], "go_terms": ["GO:0005664:nuclear origin of replication recognition complex:C", "GO:0006260:DNA replication:P"], "name": "ORC6_met/pln", "pathway_ids": ["R-DDI-68689", "R-SPO-176187", "R-HSA-68949", "R-SPO-68616", "R-BTA-68616", "R-DME-68949", "R-MMU-68962", "R-HSA-113507", "R-BTA-68949", "R-HSA-68867", "R-MMU-68949", "R-HSA-68689", "R-HSA-176187", "R-BTA-68962", "R-DME-68616", "R-BTA-176187", "R-HSA-68616", "R-DME-68689", "R-DME-68962", "R-DDI-68962", "R-SPO-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949", "R-BTA-68689", "R-DME-176187", "R-DDI-68616"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68949:r:Orc1 removal from chromatin", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication"], "type": "Family"}, "IPR020532": {"description": "Cycloeucalenol cycloisomerase", "go_ids": ["GO:0047793"], "go_terms": ["GO:0047793:cycloeucalenol cycloisomerase activity:F"], "name": "Cycloeucalenol_cycloisomerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020533": {"description": "Developmental regulator, ULTRAPETALA", "go_ids": [], "go_terms": [], "name": "Developmental_reg_ULTRAPETALA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020534": {"description": "Uncharacterised protein family YqxA", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YqxA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020536": {"description": "Thil, AANH domain", "go_ids": ["GO:0004810"], "go_terms": ["GO:0004810:CCA tRNA nucleotidyltransferase activity:F"], "name": "ThiI_AANH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020542": {"description": "Aspartate carbamoyltransferase regulatory subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "Asp_carbamoyltrfase_reg_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020545": {"description": "Aspartate carbamoyltransferase regulatory subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "Asp_carbamoyltransf_reg_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020546": {"description": "ATP synthase, F1 complex, delta/epsilon subunit, N-terminal", "go_ids": ["GO:0015986"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P"], "name": "ATP_synth_F1_dsu/esu_N", "pathway_ids": ["R-BTA-8949613", "R-CEL-163210", "R-MMU-163210", "R-BTA-163210", "R-CEL-8949613", "R-RNO-163210", "R-RNO-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-BTA-8949613:r:Cristae formation", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Domain"}, "IPR020547": {"description": "ATP synthase epsilon subunit, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ATP_synth_F1_esu_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020560": {"description": "Phosphoribosylglycinamide synthetase, C-domain", "go_ids": ["GO:0004637", "GO:0009113"], "go_terms": ["GO:0004637:phosphoribosylamine-glycine ligase activity:F", "GO:0009113:purine nucleobase biosynthetic process:P"], "name": "PRibGlycinamide_synth_C-dom", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-BTA-73817", "R-MMU-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817", "R-GGA-419140"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Domain"}, "IPR020561": {"description": "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain", "go_ids": [], "go_terms": [], "name": "PRibGlycinamid_synth_ATP-grasp", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-BTA-73817", "R-MMU-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817", "R-GGA-419140"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Domain"}, "IPR020562": {"description": "Phosphoribosylglycinamide synthetase, N-terminal", "go_ids": ["GO:0004637", "GO:0009113"], "go_terms": ["GO:0004637:phosphoribosylamine-glycine ligase activity:F", "GO:0009113:purine nucleobase biosynthetic process:P"], "name": "PRibGlycinamide_synth_N", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-BTA-73817", "R-MMU-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817", "R-GGA-419140"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Domain"}, "IPR020566": {"description": "Histidine biosynthesis bifunctional protein HisB", "go_ids": ["GO:0004401", "GO:0004424", "GO:0000105"], "go_terms": ["GO:0004401:histidinol-phosphatase activity:F", "GO:0004424:imidazoleglycerol-phosphate dehydratase activity:F", "GO:0000105:L-histidine biosynthetic process:P"], "name": "His_synth_bifunc_HisB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020568": {"description": "Ribosomal protein uS5 domain 2-type superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_Su5_D2-typ_SF", "pathway_ids": ["R-DME-3371568", "R-CEL-9937383", "R-SSC-975957", "R-HSA-399954", "R-HSA-450604", "R-DRE-3371571", "R-DME-5389840", "R-MMU-9013418", "R-MMU-6785807", "R-RNO-380270", "R-MMU-3371497", "R-DDI-72689", "R-SSC-6798695", "R-CEL-1227986", "R-SCE-72706", "R-DDI-9009391", "R-BTA-3371511", "R-DME-72649", "R-CEL-3371511", "R-HSA-156827", "R-RNO-9930044", "R-RNO-450604", "R-HSA-9836573", "R-RNO-2565942", "R-DME-1799339", "R-HSA-912446", "R-BTA-380320", "R-DME-8863795", "R-HSA-4615885", "R-DME-8937144", "R-CEL-1474151", "R-HSA-3371568", "R-RNO-71403", "R-SCE-72689", "R-DDI-5358565", "R-MMU-975956", "R-RNO-9013418", "R-SCE-156827", "R-HSA-9665249", "R-DDI-1474151", "R-CEL-5389840", "R-DME-6798695", "R-MMU-1227986", "R-MMU-5675482", "R-SCE-9009391", "R-SSC-4420097", "R-BTA-5218920", "R-MMU-3371571", "R-HSA-72764", "R-BTA-844456", "R-MMU-3214858", "R-MMU-1474151", "R-HSA-6787639", "R-HSA-9009391", "R-CEL-5675482", "R-DME-9954714", "R-DDI-3371497", "R-RNO-429958", "R-SCE-156902", "R-DDI-450385", "R-SCE-9837999", "R-CEL-5419276", "R-DME-8939211", "R-SCE-844456", "R-DDI-975957", "R-DDI-1799339", "R-MMU-6787639", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-HSA-6798695", "R-DRE-3371568", "R-HSA-3000484", "R-DRE-450385", "R-HSA-5419276", "R-XTR-6791226", "R-SSC-3371511", "R-HSA-9920588", "R-XTR-450385", "R-DME-3371497", "R-SPO-3371571", "R-CEL-6798695", "R-DDI-446199", "R-DME-6791226", "R-BTA-3371568", "R-BTA-6798695", "R-MMU-4420097", "R-HSA-6796648", "R-MMU-2565942", "R-RNO-380320", "R-MMU-72706", "R-BTA-9033241", "R-DME-2029482", "R-MMU-9954716", "R-HSA-380994", "R-SPO-9009391", "R-DME-3371571", "R-DRE-6798695", "R-CEL-429958", "R-HSA-8939211", "R-MMU-381426", "R-MMU-399954", "R-DDI-9954714", "R-DME-4615885", "R-HSA-5545483", "R-CEL-72706", "R-RNO-1474151", "R-CEL-381426", "R-BTA-5620912", "R-SSC-3371571", "R-HSA-9652282", "R-CEL-9954716", "R-CEL-9954714", "R-DRE-9018519", "R-BTA-8863795", "R-SSC-72706", "R-HSA-5632987", "R-RNO-8937144", "R-SPO-975956", "R-BTA-156827", "R-DDI-429958", "R-SSC-380259", "R-RNO-156827", "R-SPO-72706", "R-BTA-450513", "R-SPO-5358565", "R-DME-9018519", "R-SCE-975956", "R-HSA-5675482", "R-CEL-6785807", "R-DDI-6785807", "R-DDI-3214858", "R-BTA-3371571", "R-SPO-5218920", "R-HSA-2029482", "R-HSA-9735869", "R-RNO-844456", "R-BTA-446199", "R-DDI-203615", "R-RNO-6791226", "R-RNO-381426", "R-GGA-5358565", "R-DDI-399954", "R-MMU-450604", "R-BTA-168928", "R-MMU-8854518", "R-MMU-6798695", "R-CEL-9930044", "R-DME-1474151", "R-HSA-70370", "R-DDI-8939211", "R-CEL-8937144", "R-HSA-9954714", "R-BTA-72649", "R-BTA-3371497", "R-DDI-9930044", "R-HSA-844456", "R-MMU-1799339", "R-MMU-8863795", "R-DDI-975956", "R-SPO-72702", "R-SPO-6798695", "R-SSC-380270", "R-HSA-9930044", "R-CEL-8863795", "R-MMU-450385", "R-MMU-9937383", "R-SPO-1474151", "R-CEL-72702", "R-CEL-72695", "R-MMU-3000480", "R-MMU-72649", "R-BTA-5675482", "R-RNO-2029482", "R-HSA-192823", "R-HSA-2565942", "R-SSC-72695", "R-BTA-5389840", "R-SSC-156827", "R-CFA-8957275", "R-DME-9009391", "R-SSC-2029482", "R-RNO-8852276", "R-DDI-156902", "R-SCE-3371571", "R-CEL-4615885", "R-HSA-9969896", "R-DME-72695", "R-MMU-72702", "R-MMU-168928", "R-BTA-429958", "R-DRE-450513", "R-RNO-8854518", "R-HSA-9665246", "R-MMU-5218920", "R-XTR-429958", "R-SSC-975956", "R-BTA-71403", "R-HSA-1227986", "R-HSA-9665233", "R-HSA-9937383", "R-HSA-72689", "R-SPO-8876725", "R-MMU-9033241", "R-DME-3371511", "R-SCE-9954714", "R-HSA-9754678", "R-MMU-2029482", "R-SSC-168928", "R-DDI-3371571", "R-SSC-72649", "R-BTA-9954714", "R-SPO-3371497", "R-SPO-3371511", "R-SCE-72649", "R-SPO-446199", "R-SPO-9837999", "R-BTA-975956", "R-MMU-5419276", "R-HSA-8957275", "R-DDI-5358493", "R-HSA-380259", "R-CFA-3000480", "R-RNO-8939211", "R-CEL-5218920", "R-HSA-9033241", "R-HSA-9633012", "R-BTA-6785807", "R-HSA-9913143", "R-BTA-1679131", "R-RNO-6785807", "R-HSA-9013418", "R-HSA-9665251", "R-BTA-450385", "R-DME-9652282", "R-RNO-9009391", 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"R-RNO-6798695", "R-SPO-72689", "R-CEL-72689", "R-SSC-1227986", "R-SCE-3371497", "R-DME-5358493", "R-RNO-4615885", "R-SCE-4615885", "R-SCE-8876725", "R-SPO-4615885", "R-RNO-5358493", "R-HSA-9705671", "R-HSA-1474151", "R-HSA-168928", "R-HSA-3000480", "R-HSA-9954716", "R-MMU-8852276", "R-MMU-72689", "R-DDI-6791226", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-9665737", "R-CEL-3371571", "R-HSA-9665348", "R-HSA-3371497", "R-MMU-8937144", "R-MMU-380284", "R-HSA-6790901", "R-BTA-72706", "R-HSA-5336415", "R-DME-3214858", "R-BTA-70370", "R-SCE-5358565", "R-SPO-1799339", "R-SCE-1799339", "R-HSA-72165", "R-HSA-9837999", "R-DDI-71403", "R-SPO-429958", "R-SSC-8863795", "R-SCE-72695", "R-MMU-72695", "R-SPO-9969896", "R-DDI-2029482", "R-RNO-5389840", "R-DDI-9837999", "R-BTA-9954716", "R-MMU-975957", "R-HSA-9841251", "R-DME-72689", "R-RNO-1227986", "R-RNO-72702", "R-HSA-9665250", "R-HSA-380270", "R-BTA-9009391", "R-DRE-844456", "R-DME-203615", "R-MMU-156827", "R-HSA-72649", "R-RNO-380259", "R-SCE-8939211", "R-CFA-6785807", "R-HSA-5609976", "R-HSA-450385", "R-HSA-975957", "R-HSA-611105", "R-MMU-450513", "R-HSA-9634285", "R-MMU-72165", "R-HSA-450513", "R-HSA-3371571", "R-DME-5419276", "R-BTA-5419276", "R-CEL-9009391", "R-SPO-72163", "R-RNO-3000480", "R-HSA-2426168", "R-SSC-5620912", "R-SCE-5218920", "R-RNO-9954714", "R-RNO-9969896", "R-DRE-399954", "R-BTA-8939211", "R-CEL-975957", "R-CEL-156902", "R-RNO-3214858", "R-CEL-9652282", "R-SSC-9013418", "R-HSA-380284", "R-SSC-399954", "R-BTA-2029482", "R-HSA-8854518", "R-MMU-8957275", "R-DME-156902", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-HSA-4420097", "R-SCE-450385", "R-HSA-380320", "R-HSA-975956", "R-BTA-72689", "R-RNO-1679131", "R-BTA-380259", "R-RNO-9954716", "R-RNO-5419276", "R-CEL-8957275", "R-BTA-72695", "R-BTA-9969896", "R-CEL-6791226", "R-HSA-429958", "R-BTA-9013418", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-9018519", "R-HSA-381426", "R-CEL-203615", "R-HSA-5601884", "R-BTA-8876725", "R-RNO-975957", "R-HSA-1799339", "R-HSA-9638771", "R-DME-1227986", "R-HSA-9665244", "R-HSA-9665686", "R-MMU-8939211", "R-CEL-9837999", "R-MMU-9954714", "R-CEL-5358493", "R-DRE-450604", "R-DDI-72695", "R-CEL-1799339", "R-SCE-3214858", "R-HSA-6785807", "R-XTR-450604", "R-BTA-9937383", "R-MMU-9018519", "R-CEL-156827", "R-SSC-380284", "R-BTA-9930044", "R-SPO-9652282", "R-MMU-70370", "R-XTR-9930044", "R-HSA-1362277", "R-MMU-5358493", "R-HSA-6791226", "R-RNO-975956", "R-SSC-72689", "R-SCE-203615", "R-HSA-9613829", "R-RNO-9652282", "R-SPO-156827", "R-MMU-5389840", "R-DDI-72702", "R-RNO-4420097", "R-BTA-450604", "R-HSA-3371511", "R-HSA-8876725", "R-DME-156827", "R-HSA-5358606", "R-DRE-2029482", "R-BTA-9652282", "R-MMU-429958", "R-MMU-203615", "R-RNO-5620912", "R-RNO-72689", "R-XTR-450513", "R-HSA-3214858", "R-HSA-9665245", "R-SPO-156902", "R-MMU-4615885", "R-RNO-3371568", "R-SCE-975957", "R-BTA-399954", "R-RNO-8957275", "R-HSA-1236382", "R-BTA-381426", "R-SPO-3214858", "R-HSA-5620912", "R-DRE-8939211", "R-HSA-9918481", "R-SSC-72702", "R-BTA-380284", "R-HSA-8937144", "R-DRE-5419276", "R-CFA-381426", "R-DME-975956", "R-HSA-9820962", "R-DRE-3371511", "R-RNO-5358565", "R-HSA-390471", "R-SPO-72649", "R-SPO-72695", "R-SCE-450513", "R-DME-9837999", "R-HSA-8852276", "R-HSA-156902", "R-HSA-9679191", "R-CEL-8876725", "R-RNO-9837999", "R-DRE-5389840", "R-MMU-844456", "R-SSC-8852276", "R-DME-9013418", "R-MMU-156902", "R-MMU-8876725", "R-SPO-203615", "R-HSA-1679131", "R-BTA-1799339", "R-BTA-8937144", "R-DRE-8876725", "R-BTA-380270", "R-BTA-8854518", "R-CFA-1679131", "R-HSA-5358493", "R-RNO-8876725", "R-MMU-9837999", "R-SSC-380320", "R-RNO-5675482", "R-HSA-5358565", "R-DDI-72706", "R-DDI-9969896", "R-RNO-168928", "R-SCE-3371511", "R-DDI-450513", "R-SPO-6791226", "R-SSC-9954716", "R-DDI-9954716", "R-SCE-9969896", "R-HSA-9646399", "R-SSC-3371497", "R-BTA-975957", "R-CEL-450385", "R-BTA-1227986", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-446199", "R-SPO-9930044", "R-BTA-5358493", "R-RNO-9018519", "R-DRE-156902", "R-RNO-5218920", "R-DME-72706", "R-HSA-203615", "R-HSA-72695", "R-RNO-399954", "R-DRE-9969896", "R-DRE-9930044", "R-CEL-8939211", "R-HSA-8863795", "R-BTA-4420097", "R-SCE-6791226", "R-HSA-5368286", "R-MMU-3371511", "R-HSA-5389840", "R-MMU-9930044", "R-DDI-6798695", "R-BTA-203615", "R-MMU-71403", "R-HSA-381183", "R-SPO-844456", "R-MMU-380259", "R-DRE-429958", "R-BTA-72702", "R-RNO-3371511", "R-HSA-72706", "R-SCE-1474151", "R-DDI-844456", "R-SSC-9018519", "R-CFA-70370", "R-DDI-8876725", "R-RNO-203615", "R-DME-5218920", "R-RNO-446199", "R-HSA-72163"], "pathways": ["R-DME-3371568:r:Attenuation phase", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DRE-3371571:r:HSF1-dependent transactivation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-SSC-6798695:r:Neutrophil degranulation", "R-CEL-1227986:r:Signaling by ERBB2", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-3371511:r:HSF1 activation", "R-DME-72649:r:Translation initiation complex formation", "R-CEL-3371511:r:HSF1 activation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-9930044:r:Nuclear RNA decay", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-912446:r:Meiotic recombination", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-DME-8937144:r:Aryl hydrocarbon receptor signalling", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-3371568:r:Attenuation phase", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-1227986:r:Signaling by ERBB2", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-844456:r:The NLRP3 inflammasome", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-6787639:r:GDP-fucose biosynthesis", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-5675482:r:Regulation of necroptotic cell death", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SCE-156902:r:Peptide chain elongation", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DME-8939211:r:ESR-mediated signaling", "R-SCE-844456:r:The NLRP3 inflammasome", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6787639:r:GDP-fucose biosynthesis", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-3371568:r:Attenuation phase", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-DRE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-5419276:r:Mitochondrial translation termination", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-3371511:r:HSF1 activation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-XTR-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-CEL-6798695:r:Neutrophil degranulation", "R-DDI-446199:r:Synthesis of dolichyl-phosphate", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-3371568:r:Attenuation phase", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-9033241:r:Peroxisomal protein import", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-DME-3371571:r:HSF1-dependent transactivation", "R-DRE-6798695:r:Neutrophil degranulation", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-8939211:r:ESR-mediated signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SSC-3371571:r:HSF1-dependent transactivation", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-5632987:r:Defective Mismatch Repair 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"R-MMU-9837999:r:Mitochondrial protein degradation", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-RNO-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SCE-3371511:r:HSF1 activation", "R-DDI-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-HSA-9646399:r:Aggrephagy", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-1227986:r:Signaling by ERBB2", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-446199:r:Synthesis of dolichyl-phosphate", "R-SPO-9930044:r:Nuclear RNA decay", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-DRE-156902:r:Peptide chain elongation", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-203615:r:eNOS activation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-9969896:r:Lanosterol biosynthesis", "R-DRE-9930044:r:Nuclear RNA decay", "R-CEL-8939211:r:ESR-mediated signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-3371511:r:HSF1 activation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-9930044:r:Nuclear RNA decay", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-203615:r:eNOS activation", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-381183:r:ATF6 (ATF6-alpha) activates chaperone genes", "R-SPO-844456:r:The NLRP3 inflammasome", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-3371511:r:HSF1 activation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-844456:r:The NLRP3 inflammasome", "R-SSC-9018519:r:Estrogen-dependent gene expression", "R-CFA-70370:r:Galactose catabolism", "R-DDI-8876725:r:Protein methylation", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-72163:r:mRNA Splicing - Major Pathway"], "type": "Homologous_superfamily"}, "IPR020573": {"description": "UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, non-repeat region", "go_ids": ["GO:0009245", "GO:0016747"], "go_terms": ["GO:0009245:lipid A biosynthetic process:P", "GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "UDP_GlcNAc_AcTrfase_non-rep", "pathway_ids": ["PWY-8245", "PWY-8073", "PWY-8283"], "pathways": ["PWY-8245:t:lipid IVA biosynthesis (P. gingivalis)", "PWY-8073:t:lipid IVA biosynthesis (P. putida)", "PWY-8283:t:lipid IVA biosynthesis (generic)"], "type": "Domain"}, "IPR020579": {"description": "Exonuclease VII, large subunit, C-terminal", "go_ids": ["GO:0008855"], "go_terms": ["GO:0008855:exodeoxyribonuclease VII activity:F"], "name": "Exonuc_VII_lsu_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020581": {"description": "Glycine cleavage system P protein", "go_ids": ["GO:0006546", "GO:0004375"], "go_terms": ["GO:0006546:glycine catabolic process:P", "GO:0004375:glycine dehydrogenase (decarboxylating) activity:F"], "name": "GDC_P", "pathway_ids": ["R-DDI-6783984", "R-SPO-6783984", "R-MMU-6783984", "R-SCE-6783984", "R-HSA-6783984"], "pathways": ["R-DDI-6783984:r:Glycine degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-6783984:r:Glycine degradation", "R-SCE-6783984:r:Glycine degradation", "R-HSA-6783984:r:Glycine degradation"], "type": "Family"}, "IPR020594": {"description": "Large ribosomal subunit protein bL9, bacteria/chloroplast", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_bL9_bact/chp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020598": {"description": "Ribosomal RNA adenine methylase transferase, N-terminal", "go_ids": ["GO:0000154", "GO:0000179"], "go_terms": ["GO:0000154:rRNA modification:P", "GO:0000179:rRNA (adenine-N6,N6-)-dimethyltransferase activity:F"], "name": "rRNA_Ade_methylase_Trfase_N", "pathway_ids": ["R-HSA-6793080", "R-MMU-163282", "R-HSA-2151201", "R-HSA-163282", "R-BTA-163282", "R-RNO-163282", "R-HSA-6790901"], "pathways": ["R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-MMU-163282:r:Mitochondrial transcription initiation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-163282:r:Mitochondrial transcription initiation", "R-BTA-163282:r:Mitochondrial transcription initiation", "R-RNO-163282:r:Mitochondrial transcription initiation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR020599": {"description": "Translation elongation factor P/YeiP", "go_ids": [], "go_terms": [], "name": "Transl_elong_fac_P/YeiP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020600": {"description": "Inosine monophosphate cyclohydrolase-like", "go_ids": ["GO:0006164", "GO:0006188", "GO:0003937"], "go_terms": ["GO:0006164:purine nucleotide biosynthetic process:P", "GO:0006188:IMP biosynthetic process:P", "GO:0003937:IMP cyclohydrolase activity:F"], "name": "IMP_cyclohydrolase-like", "pathway_ids": ["PWY-6123", "PWY-7234", "PWY-6124"], "pathways": ["PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-7234:t:inosine-5'-phosphate biosynthesis III", "PWY-6124:t:inosine-5'-phosphate biosynthesis II"], "type": "Domain"}, "IPR020602": {"description": "GTP cyclohydrolase I domain", "go_ids": [], "go_terms": [], "name": "GTP_CycHdrlase_I_dom", "pathway_ids": ["PWY-6147", "PWY-7852", 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"R-DDI-77108:r:Utilization of Ketone Bodies", "R-MMU-77108:r:Utilization of Ketone Bodies", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-77108:r:Utilization of Ketone Bodies", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9969896:r:Lanosterol biosynthesis", "PWY-8182:t:valproate beta-oxidation", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-6435:t:4-hydroxybenzoate biosynthesis III (plants)", "PWY-6443:t:benzoate biosynthesis I (CoA-dependent, beta-oxidative)", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-481:t:ethylbenzene degradation (anaerobic)", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-6458:t:benzoyl-CoA biosynthesis", "PWY-7948:t:4-oxopentanoate degradation", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-7094:t:fatty acid salvage", "PWY-8179:t:platensimycin biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-6080:t:4-ethylphenol degradation (anaerobic)", "R-RNO-1482798:r:Acyl chain remodeling of CL", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-77111:r:Synthesis of Ketone Bodies", "R-CEL-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-RNO-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR020617": {"description": "Thiolase, C-terminal", "go_ids": ["GO:0016747"], "go_terms": ["GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "Thiolase_C", "pathway_ids": ["PWY-8182", "PWY-7339", "PWY-735", "PWY-7338", "PWY-6435", "PWY-6443", "PWY-6946", "PWY-481", "PWY-8181", "PWY-6945", "PWY-8463", "PWY-6458", "PWY-7948", "PWY-8152", "PWY-6948", "PWY-7340", "PWY-7726", "PWY-6944", "PWY-7288", "PWY-7654", "PWY-5109", "PWY-5136", "PWY-7337", "PWY-7094", "PWY-8179", "PWY-7606", "PWY-6080", "R-RNO-1482798", "R-HSA-6798695", "R-DRE-77111", "R-CEL-77348", "R-RNO-2046106", "R-HSA-77346", "R-RNO-77305", "R-RNO-9033241", "R-MMU-77346", "R-RNO-77285", "R-MMU-9854311", "R-RNO-77289", "R-BTA-9837999", "R-SCE-9033241", "R-MMU-1482798", "R-BTA-1482798", "R-DRE-70895", "R-DRE-77108", "R-CEL-77346", "R-HSA-77289", 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myristoyl-CoA", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-77108:r:Utilization of Ketone Bodies", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR020618": {"description": "Adenylate kinase isoenzyme 6", "go_ids": ["GO:0004017", "GO:0005524", "GO:0016887"], "go_terms": ["GO:0004017:AMP kinase activity:F", "GO:0005524:ATP binding:F", "GO:0016887:ATP hydrolysis activity:F"], "name": "Adenyl_kinase_AK6", "pathway_ids": ["PWY-7219", "R-DME-499943", "R-PFA-499943", "R-RNO-499943", "R-BTA-499943", "R-CEL-499943", "R-SCE-499943", "R-SPO-499943", "R-HSA-499943", "R-DDI-499943", "R-MMU-499943"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-PFA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR020627": {"description": "RNA-binding protein KhpA", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "KhpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020629": {"description": "Formamidopyrimidine-DNA glycosylase", "go_ids": ["GO:0006281", "GO:0008270", "GO:0008534", "GO:0003906"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0008270:zinc ion binding:F", "GO:0008534:oxidized purine nucleobase lesion DNA N-glycosylase activity:F", "GO:0003906:DNA-(apurinic or apyrimidinic site) endonuclease activity:F"], "name": "FPG_Glyclase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020630": {"description": "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain", "go_ids": ["GO:0004488"], "go_terms": ["GO:0004488:methylenetetrahydrofolate dehydrogenase (NADP+) activity:F"], "name": "THF_DH/CycHdrlase_cat_dom", "pathway_ids": ["PWY-5030", "PWY-6613", "PWY-1722", "PWY-2201", "PWY-5497", "PWY-8303", "PWY-3841", "PWY-7909", "R-DME-196757", "R-MMU-196757", "R-BTA-196757", "R-RNO-196757", "R-SCE-196757", "R-SPO-196757", "R-HSA-196757"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-6613:t:tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate", "PWY-1722:t:formate assimilation into 5,10-methylenetetrahydrofolate", "PWY-2201:t:folate transformations I", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-3841:t:folate transformations II (plants)", "PWY-7909:t:formaldehyde oxidation VII (THF pathway)", "R-DME-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines", "R-BTA-196757:r:Metabolism of folate and pterines", "R-RNO-196757:r:Metabolism of folate and pterines", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines"], "type": "Domain"}, "IPR020631": {"description": "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain", "go_ids": ["GO:0004488"], "go_terms": ["GO:0004488:methylenetetrahydrofolate dehydrogenase (NADP+) activity:F"], "name": "THF_DH/CycHdrlase_NAD-bd_dom", "pathway_ids": ["PWY-5030", "PWY-6613", "PWY-1722", "PWY-2201", "PWY-5497", "PWY-8303", "PWY-3841", "PWY-7909", "R-DME-196757", "R-MMU-196757", "R-BTA-196757", "R-RNO-196757", "R-SCE-196757", "R-SPO-196757", "R-HSA-196757"], 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"R-MMU-8851907", "R-MMU-5654687", "R-MMU-9032759", "R-RNO-5654733", "R-HSA-9027277", "R-HSA-2428928", "R-HSA-428890", "R-MMU-9696273", "R-HSA-9725370", "R-DME-210688", "R-GGA-388844", "R-MMU-9856649", "R-HSA-186797", "R-HSA-6798695", "R-MMU-416476", "R-HSA-8849469", "R-HSA-8875555", "R-DRE-5654689", "R-MMU-1306955", "R-HSA-112411", "R-HSA-9669929", "R-GGA-2029482", "R-MMU-4420097", "R-RNO-191650", "R-RNO-190370", "R-HSA-5654693", "R-RNO-198203", "R-MMU-3000171", "R-DRE-69231", "R-CFA-5673001", "R-HSA-399955", "R-DRE-5654726", "R-DRE-877300", "R-HSA-5654221", "R-HSA-9652282", "R-CEL-216083", "R-HSA-9717264", "R-CEL-9841922", "R-HSA-9024909", "R-CEL-5663213", "R-SSC-9032759", "R-HSA-9013695", "R-MMU-202427", "R-MMU-8875513", "R-GGA-3928663", "R-DRE-5654700", "R-HSA-9013407", "R-DRE-456926", "R-MMU-8863795", "R-MMU-2179392", "R-HSA-5654687", "R-SSC-877312", "R-MMU-8852405", "R-CEL-3928663", "R-RNO-110056", "R-DME-428890", "R-HSA-9938206", "R-CEL-5654710", "R-HSA-9025046", "R-DRE-1059683", "R-HSA-9674403", "R-MMU-9603381", "R-CEL-418592", "R-HSA-216083", "R-DDI-3295583", "R-RNO-9034793", "R-CEL-445144", "R-HSA-9665233", "R-CEL-416572", "R-MMU-1169408", "R-HSA-186763", "R-HSA-177504", "R-HSA-9706377", "R-MMU-6783783", "R-SSC-389357", "R-MMU-3928662", "R-HSA-5654710", "R-RNO-9766229", "R-RNO-202430", "R-DME-179812", "R-DME-9013423", "R-MMU-177929", "R-RNO-2871837", "R-RNO-1306955", "R-HSA-9607240", "R-CEL-3928664", "R-MMU-8941858", "R-HSA-9026357", "R-HSA-9006335", "R-RNO-202433", "R-MMU-9009391", "R-HSA-5693565", "R-HSA-9669935", "R-HSA-6806942", "R-DRE-5621575", "R-HSA-202427", "R-RNO-8847993", "R-CEL-1257604", "R-RNO-210990", "R-MMU-5654706", "R-HSA-389359", "R-SSC-112411", "R-RNO-1963642", "R-HSA-2682334", "R-DRE-5621480", "R-DME-1251985", "R-HSA-114604", "R-DME-9013149", "R-HSA-5654689", "R-HSA-418592", "R-RNO-9732724", "R-RNO-2029481", "R-RNO-9013407", "R-HSA-983231", "R-SSC-3928662", "R-HSA-9702590", "R-DRE-909733", "R-DME-1253288", "R-CEL-5654727", "R-HSA-8851708", "R-HSA-1433559", "R-DME-1257604", "R-DME-416482", "R-MMU-9851151", "R-SSC-9734091", "R-MMU-186797", "R-BTA-2424491", "R-SSC-1227986", "R-HSA-5638303", "R-MMU-190374", "R-GGA-9856649", "R-HSA-9665348", "R-RNO-9027284", "R-HSA-2454202", "R-MMU-8874081", "R-HSA-8849470", "R-MMU-9013507", "R-HSA-9028335", "R-HSA-5654719", "R-HSA-9032845", "R-SSC-8851907", "R-HSA-9702636", "R-RNO-1170546", "R-SSC-1059683", "R-DME-1250342", "R-DME-428542", "R-DRE-1307965", "R-HSA-5654712", "R-RNO-2682334", "R-SSC-9006335", "R-HSA-9717319", "R-HSA-190370", "R-RNO-2454202", "R-HSA-9717326", "R-HSA-74752", "R-MMU-5654693", "R-MMU-6807004", "R-HSA-5663220", "R-MMU-525793", "R-HSA-9856530", "R-SSC-8865999", "R-HSA-9020956", "R-HSA-202733", "R-DME-5654733", "R-DRE-1433557", "R-BTA-389357", "R-MMU-8985947", "R-DRE-9732724", "R-HSA-9700645", "R-CEL-1253288", "R-DRE-6783783", "R-DRE-194306", "R-DME-190371", "R-HSA-9766229", "R-CEL-187577", "R-MMU-9013404", "R-MMU-1295596", "R-HSA-3928662", "R-DME-1307965", "R-HSA-9707564", "R-MMU-9020558", "R-MMU-5654732", "R-RNO-9026527", "R-HSA-9665247", "R-CEL-5654693", "R-HSA-9825892", "R-HSA-6783783", "R-CEL-190322", "R-HSA-8934903", "R-DME-1236394", "R-HSA-8849472", "R-HSA-9830364", "R-HSA-456926", "R-CEL-190375", "R-MMU-8853659", "R-HSA-5654732", "R-HSA-2219530", "R-MMU-445144", "R-HSA-6785807", "R-DME-5654688", "R-RNO-77387", "R-MMU-9705462", "R-GGA-6798695", "R-HSA-75892", "R-DME-110478", "R-DRE-177929", "R-HSA-9620244", "R-GGA-2730905", "R-RNO-1358803", "R-MMU-2871837", "R-HSA-9702998", "R-HSA-5603041", "R-HSA-9860927", "R-HSA-9674555", "R-HSA-198203", "R-RNO-4420097", "R-DRE-190370", "R-MMU-69231", "R-GGA-983695", "R-CEL-8849469", "R-BTA-389356", "R-DME-9860927", "R-HSA-3214858", "R-CEL-9013149", "R-CEL-399955", "R-MMU-2428928", "R-GGA-6811558", "R-HSA-912694", "R-RNO-170984", "R-HSA-171007", "R-HSA-9734091", "R-DME-8856825", "R-HSA-9013420", "R-GGA-210990", "R-HSA-9032500", "R-MMU-2454202", "R-RNO-180292", "R-CEL-418594", "R-RNO-114604", "R-MMU-2871809", "R-BTA-389513", "R-SSC-8875791", "R-HSA-9022699", "R-RNO-1250196", "R-DME-5654726", "R-DRE-373753", "R-RNO-1250347", "R-HSA-9669921", "R-HSA-6802952", "R-RNO-372708", "R-MMU-6811558", "R-RNO-9020558", "R-HSA-912631", "R-DME-9020558", "R-RNO-187042", "R-HSA-9732724", "R-GGA-354192", "R-HSA-1306955", "R-MMU-8948751", "R-RNO-416550", "R-DME-8948751", "R-RNO-912631", "R-MMU-202430", "R-DRE-3928664", "R-RNO-399954", "R-BTA-4420097", "R-SSC-9705462", "R-SSC-8866376", "R-HSA-9013507", "R-MMU-186763", "R-DRE-112411", "R-HSA-1170546", "R-HSA-74713", "R-HSA-983695", "R-DME-210991", "R-DME-6785631", "R-CEL-5674135", "R-CEL-212676", "R-HSA-9820960", "R-RNO-456926", "R-DME-416572", "R-HSA-909733", "R-HSA-389357", "R-RNO-388844", "R-MMU-170984", "R-CEL-8948751", "R-CEL-6811558", "R-MMU-9766229", "R-MMU-354192", "R-HSA-8865999", "R-MMU-6785807", "R-HSA-9702620", "R-MMU-5654227", "R-HSA-9833109", "R-HSA-191650", "R-CEL-5654720", "R-MMU-191650", "R-DRE-5654221", "R-HSA-9717329", "R-RNO-389359", "R-HSA-877312", "R-RNO-3928662", "R-RNO-1251985", "R-HSA-190372", "R-CEL-8856828", "R-BTA-399956", "R-HSA-5655332", "R-DME-5654719", "R-HSA-2871809", "R-DME-8939236", "R-DRE-9851151", "R-HSA-110056", "R-DME-177929", "R-HSA-9634638", "R-HSA-1358803", "R-DME-512988", "R-HSA-9669934", "R-HSA-8853336", "R-MMU-2029481", "R-MMU-389513", "R-RNO-74713", "R-DDI-5675221", "R-HSA-9725371", "R-DRE-9009391", "R-RNO-9032759", "R-RNO-983695", "R-DRE-4420097", "R-HSA-9856649", "R-BTA-3928665", "R-HSA-8853333", "R-HSA-9702518", "R-HSA-391160", "R-MMU-1253288", "R-MMU-1433559", "R-SSC-9020591", "R-DRE-5674135", "R-HSA-8856828", "R-HSA-5654228", "R-RNO-416572", "R-HSA-2029481", "R-RNO-8983432", "R-RNO-9027276", "R-HSA-9717301", "R-CEL-5673001", "R-BTA-75892", "R-CEL-5654732", "R-MMU-399954", "R-RNO-170968", "R-CEL-5654228", "R-HSA-9673767", "R-RNO-8865999", "R-GGA-3928662", "R-DME-5654227", "R-DME-5673000", "R-CEL-525793", "R-HSA-2404192", "R-MMU-1433557", "R-HSA-166058", "R-CEL-9860927", "R-MMU-5621575", "R-DRE-8934903", "R-CEL-180292", "R-HSA-9020933", "R-DRE-8854691"], "pathways": ["R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-SSC-9766229:r:Degradation of CDH1", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-BTA-1227986:r:Signaling by ERBB2", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-74752:r:Signaling by Insulin receptor", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-CEL-182971:r:EGFR downregulation", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-9702509:r:FLT3 mutants bind TKIs", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-186763:r:Downstream signal transduction", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-389356:r:Co-stimulation by CD28", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9702581:r:crenolanib-resistant FLT3 mutants", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-1227986:r:Signaling by ERBB2", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DRE-109704:r:PI3K Cascade", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9824272:r:Somitogenesis", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-201556:r:Signaling by ALK", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-MMU-74713:r:IRS activation", "R-HSA-8852405:r:Signaling by MST1", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-CEL-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-3928664:r:Ephrin signaling", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-BTA-210993:r:Tie2 Signaling", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CEL-6798695:r:Neutrophil degranulation", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8875791:r:MET activates STAT3", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-8866376:r:Reelin signalling pathway", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-187042:r:TRKA activation by NGF", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-3928664:r:Ephrin signaling", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9702605:r:pexidartinib-resistant FLT3 mutants", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-525793:r:Myogenesis", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9702614:r:ponatinib-resistant FLT3 mutants", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-8849473:r:PTK6 Expression", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-GGA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SSC-2424491:r:DAP12 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-1236394:r:Signaling by ERBB4", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-5673000:r:RAF activation", "R-CEL-8849470:r:PTK6 Regulates Cell Cycle", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-CEL-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-354192:r:Integrin signaling", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-DRE-9842663:r:Signaling by LTK", "R-DRE-912631:r:Regulation of signaling by CBL", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-449836:r:Other interleukin signaling", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-RNO-186797:r:Signaling by PDGF", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-MMU-6806942:r:MET Receptor Activation", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-8866376:r:Reelin signalling pathway", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-BTA-5621480:r:Dectin-2 family", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-9702600:r:midostaurin-resistant FLT3 mutants", "R-SSC-8875656:r:MET receptor recycling", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-210993:r:Tie2 Signaling", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9702632:r:sunitinib-resistant FLT3 mutants", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-DME-209209:r:Formation of the activated receptor complex", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-449836:r:Other interleukin signaling", "R-RNO-5673000:r:RAF activation", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-182971:r:EGFR downregulation", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-445144:r:Signal transduction by L1", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-BTA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9717316:r:alectinib-resistant ALK mutants", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-SSC-2029481:r:FCGR activation", "R-MMU-3928664:r:Ephrin signaling", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-BTA-3928664:r:Ephrin signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-DRE-8874081:r:MET activates PTK2 signaling", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-8875656:r:MET receptor recycling", "R-CEL-186797:r:Signaling by PDGF", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-187042:r:TRKA activation by NGF", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-RNO-8866376:r:Reelin signalling pathway", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-DME-1227986:r:Signaling by ERBB2", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-RNO-8853659:r:RET signaling", "R-CEL-177929:r:Signaling by EGFR", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", "R-DRE-190373:r:FGFR1c ligand binding and activation", "R-CEL-432142:r:Platelet sensitization by LDL", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DRE-210990:r:PECAM1 interactions", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-GGA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-418885:r:DCC mediated attractive signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-354192:r:Integrin signaling", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-SSC-6807004:r:Negative regulation of MET activity", "R-SSC-9020956:r:Interleukin-27 signaling", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-DME-77387:r:Insulin receptor recycling", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-432142:r:Platelet sensitization by LDL", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-RNO-389356:r:Co-stimulation by CD28", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9830674:r:Formation of the ureteric bud", "R-BTA-1433559:r:Regulation of KIT signaling", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DRE-1295596:r:Spry regulation of FGF signaling", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-1266695:r:Interleukin-7 signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-167021:r:PLC-gamma1 signalling", "R-CEL-5673000:r:RAF activation", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-SSC-982772:r:Growth hormone receptor signaling", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-HSA-9609690:r:HCMV Early Events", "R-GGA-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8875656:r:MET receptor recycling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8851805:r:MET activates RAS signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-6806942:r:MET Receptor Activation", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-8874081:r:MET activates PTK2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-912631:r:Regulation of signaling by CBL", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-CEL-77387:r:Insulin receptor recycling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-MMU-182971:r:EGFR downregulation", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-373753:r:Nephrin family interactions", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-432142:r:Platelet sensitization by LDL", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DRE-191650:r:Regulation of gap junction activity", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DME-9749641:r:Aspirin ADME", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-DME-1266695:r:Interleukin-7 signaling", "R-HSA-164944:r:Nef and signal transduction", "R-SSC-877300:r:Interferon gamma signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DRE-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-5621480:r:Dectin-2 family", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9669933:r:Signaling by kinase domain mutants of KIT", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-3928664:r:Ephrin signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-SSC-1433559:r:Regulation of KIT signaling", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-877300:r:Interferon gamma signaling", "R-GGA-1433559:r:Regulation of KIT signaling", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-9702624:r:sorafenib-resistant FLT3 mutants", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-SSC-210990:r:PECAM1 interactions", "R-MMU-1236394:r:Signaling by ERBB4", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-170984:r:ARMS-mediated activation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-5673000:r:RAF activation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-5673000:r:RAF activation", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-DRE-201556:r:Signaling by ALK", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-RNO-177929:r:Signaling by EGFR", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-HSA-9706369:r:Negative regulation of FLT3", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-BTA-180292:r:GAB1 signalosome", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-109704:r:PI3K Cascade", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-877300:r:Interferon gamma signaling", "R-HSA-180292:r:GAB1 signalosome", "R-RNO-5621480:r:Dectin-2 family", "R-DRE-1266695:r:Interleukin-7 signaling", "R-MMU-74752:r:Signaling by Insulin receptor", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-BTA-9706369:r:Negative regulation of FLT3", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-373753:r:Nephrin family interactions", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-354192:r:Integrin signaling", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-CEL-8849472:r:PTK6 Down-Regulation", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-109704:r:PI3K Cascade", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9842663:r:Signaling by LTK", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-525793:r:Myogenesis", "R-DME-180292:r:GAB1 signalosome", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-9645135:r:STAT5 Activation", "R-RNO-1266695:r:Interleukin-7 signaling", "R-CEL-6794361:r:Neurexins and neuroligins", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-GGA-389356:r:Co-stimulation by CD28", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-CEL-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-HSA-8866376:r:Reelin signalling pathway", "R-RNO-449836:r:Other interleukin signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-418885:r:DCC mediated attractive signaling", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-HSA-9702596:r:lestaurtinib-resistant FLT3 mutants", "R-RNO-1433559:r:Regulation of KIT signaling", "R-RNO-373753:r:Nephrin family interactions", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-HSA-5673000:r:RAF activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-5673000:r:RAF activation", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-RNO-6806942:r:MET Receptor Activation", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-SSC-389356:r:Co-stimulation by CD28", "R-RNO-445144:r:Signal transduction by L1", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-DME-8985947:r:Interleukin-9 signaling", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DRE-430116:r:GP1b-IX-V activation signalling", "R-HSA-9703009:r:tamatinib-resistant FLT3 mutants", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-DRE-8983432:r:Interleukin-15 signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-182971:r:EGFR downregulation", "R-HSA-8985947:r:Interleukin-9 signaling", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-CFA-9851151:r:MDK and PTN in ALK signaling", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9674404:r:Sorafenib-resistant PDGFR mutants", "R-HSA-9717323:r:ceritinib-resistant ALK mutants", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-109704:r:PI3K Cascade", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-SSC-8875555:r:MET activates RAP1 and RAC1", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-201556:r:Signaling by ALK", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-HSA-9702569:r:KW2449-resistant FLT3 mutants", "R-MMU-74749:r:Signal attenuation", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-373753:r:Nephrin family interactions", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-CEL-912631:r:Regulation of signaling by CBL", "R-SSC-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-190370:r:FGFR1b ligand binding and activation", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-177929:r:Signaling by EGFR", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-201556:r:Signaling by ALK", "R-BTA-9013407:r:RHOH GTPase cycle", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-BTA-912631:r:Regulation of signaling by CBL", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-BTA-9766229:r:Degradation of CDH1", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CFA-1433559:r:Regulation of KIT signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-SSC-399956:r:CRMPs in Sema3A signaling", "R-MMU-202433:r:Generation of second messenger molecules", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-DRE-9020958:r:Interleukin-21 signaling", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DRE-8853659:r:RET signaling", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-SSC-8851805:r:MET activates RAS signaling", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-190322:r:FGFR4 ligand binding and activation", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-RNO-9020591:r:Interleukin-12 signaling", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-198745:r:Signalling to STAT3", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-9013407:r:RHOH GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-BTA-210990:r:PECAM1 interactions", "R-SSC-912631:r:Regulation of signaling by CBL", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9702577:r:semaxanib-resistant FLT3 mutants", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DRE-1227986:r:Signaling by ERBB2", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-DRE-877312:r:Regulation of IFNG signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-373753:r:Nephrin family interactions", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9020591:r:Interleukin-12 signaling", "R-RNO-354192:r:Integrin signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-MMU-5621480:r:Dectin-2 family", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-GGA-912631:r:Regulation of signaling by CBL", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-HSA-74749:r:Signal attenuation", "R-BTA-418885:r:DCC mediated attractive signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-SSC-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-191650:r:Regulation of gap junction activity", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-69231:r:Cyclin D associated events in G1", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-877300:r:Interferon gamma signaling", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-9717264:r:ASP-3026-resistant ALK mutants", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-GGA-3928663:r:EPHA-mediated growth cone collapse", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-SSC-877312:r:Regulation of IFNG signaling", "R-MMU-8852405:r:Signaling by MST1", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-DRE-1059683:r:Interleukin-6 signaling", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-216083:r:Integrin cell surface interactions", "R-DDI-3295583:r:TRP channels", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-MMU-6783783:r:Interleukin-10 signaling", "R-SSC-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-9766229:r:Degradation of CDH1", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-HSA-6806942:r:MET Receptor Activation", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DRE-5621480:r:Dectin-2 family", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-RNO-2029481:r:FCGR activation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-HSA-9702590:r:gilteritinib-resistant FLT3 mutants", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-1433559:r:Regulation of KIT signaling", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-186797:r:Signaling by PDGF", "R-BTA-2424491:r:DAP12 signaling", "R-SSC-1227986:r:Signaling by ERBB2", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-SSC-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-9702636:r:tandutinib-resistant FLT3 mutants", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-HSA-9717319:r:brigatinib-resistant ALK mutants", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-9717326:r:crizotinib-resistant ALK mutants", "R-HSA-74752:r:Signaling by Insulin receptor", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-8865999:r:MET activates PTPN11", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-6783783:r:Interleukin-10 signaling", "R-CEL-190322:r:FGFR4 ligand binding and activation", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DME-1236394:r:Signaling by ERBB4", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-MMU-8853659:r:RET signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-77387:r:Insulin receptor recycling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-110478:r:Insulin signaling pathway", "R-DRE-177929:r:Signaling by EGFR", "R-HSA-9620244:r:Long-term potentiation", "R-GGA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9702998:r:linifanib-resistant FLT3 mutants", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-190370:r:FGFR1b ligand binding and activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-389356:r:Co-stimulation by CD28", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-171007:r:p38MAPK events", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-GGA-210990:r:PECAM1 interactions", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-180292:r:GAB1 signalosome", "R-CEL-418594:r:G alpha (i) signalling events", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-SSC-8875791:r:MET activates STAT3", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-373753:r:Nephrin family interactions", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-HSA-912631:r:Regulation of signaling by CBL", "R-DME-9020558:r:Interleukin-2 signaling", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-GGA-354192:r:Integrin signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-8866376:r:Reelin signalling pathway", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-186763:r:Downstream signal transduction", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-74713:r:IRS activation", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-210991:r:Basigin interactions", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-170984:r:ARMS-mediated activation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9702620:r:quizartinib-resistant FLT3 mutants", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-191650:r:Regulation of gap junction activity", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-MMU-191650:r:Regulation of gap junction activity", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9717329:r:lorlatinib-resistant ALK mutants", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-HSA-877312:r:Regulation of IFNG signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DRE-9851151:r:MDK and PTN in ALK signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-DME-177929:r:Signaling by EGFR", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-RNO-74713:r:IRS activation", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2029481:r:FCGR activation", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9717301:r:NVP-TAE684-resistant ALK mutants", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-170968:r:Frs2-mediated activation", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-8865999:r:MET activates PTPN11", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DME-5673000:r:RAF activation", "R-CEL-525793:r:Myogenesis", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-CEL-180292:r:GAB1 signalosome", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling"], "type": "Domain"}, "IPR020683": {"description": "Domain of unknown function DUF3447", "go_ids": [], "go_terms": [], "name": "DUF3447", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020684": {"description": "Rho-associated protein kinase 1/2", "go_ids": ["GO:0004674", "GO:0030036"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0030036:actin cytoskeleton organization:P"], "name": "ROCK1/ROCK2", "pathway_ids": ["R-RNO-9013026", "R-HSA-6798695", "R-RNO-6798695", "R-HSA-416572", "R-HSA-9013422", "R-RNO-9013422", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-416572", "R-HSA-9013106", "R-MMU-4420097", "R-MMU-416572", "R-HSA-3928662", "R-RNO-111465", "R-HSA-4420097", "R-MMU-9013422", "R-RNO-416482", "R-MMU-5627117", "R-RNO-3928662", "R-RNO-9013106", "R-MMU-111465", "R-RNO-5627117", "R-MMU-9013407", "R-RNO-9013407", "R-HSA-416482", "R-HSA-9679191", "R-HSA-9696264", "R-HSA-3928663", "R-HSA-8980692", "R-MMU-9013026", "R-MMU-416482", "R-MMU-3928662", "R-HSA-111465", "R-HSA-9013026", "R-MMU-6798695", "R-RNO-9696264", "R-MMU-9696264", "R-RNO-4420097", "R-HSA-9013407", "R-HSA-5627117"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Family"}, "IPR020751": {"description": "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2", "go_ids": [], "go_terms": [], "name": "aa-tRNA-synth_I_codon-bd_sub2", "pathway_ids": ["PWY-5188", "R-HSA-379726"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR020752": {"description": "Glutamate-tRNA synthetase, class I, anticodon-binding domain, subdomain 1", "go_ids": ["GO:0000049"], "go_terms": ["GO:0000049:tRNA binding:F"], "name": "Glu-tRNA-synth_I_codon-bd_sub1", "pathway_ids": ["PWY-5188"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)"], "type": "Homologous_superfamily"}, "IPR020761": {"description": "Uncharacterised protein family UPF0114, bacteria", "go_ids": [], "go_terms": [], "name": "UPF0114_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020777": {"description": "Growth factor receptor NTRK", "go_ids": ["GO:0004714", "GO:0005524", "GO:0005886", "GO:0006468", "GO:0007169"], "go_terms": ["GO:0004714:transmembrane receptor protein tyrosine kinase activity:F", "GO:0005524:ATP binding:F", "GO:0005886:plasma membrane:C", "GO:0006468:protein phosphorylation:P", "GO:0007169:cell surface receptor protein tyrosine kinase signaling pathway:P"], "name": "NTRK", "pathway_ids": ["R-HSA-167044", "R-HSA-187042", "R-HSA-9034015", "R-MMU-6811558", "R-HSA-9026357", "R-RNO-1257604", "R-HSA-167021", "R-HSA-198745", "R-RNO-187042", "R-HSA-9026519", "R-MMU-388844", "R-HSA-9032759", "R-MMU-9034793", "R-MMU-198203", "R-RNO-198203", "R-HSA-388844", "R-RNO-6811558", "R-HSA-9603381", "R-MMU-187042", "R-RNO-177504", "R-RNO-170968", "R-HSA-9028335", "R-GGA-6811558", "R-RNO-9034013", "R-RNO-9026527", "R-RNO-170984", "R-HSA-9032845", "R-HSA-9025046", "R-HSA-9028731", "R-HSA-170984", "R-GGA-1257604", "R-MMU-9034013", "R-HSA-9026527", "R-MMU-9603381", "R-MMU-170968", "R-HSA-9603505", "R-RNO-9034793", "R-RNO-9603381", "R-MMU-9028731", "R-HSA-9034793", "R-HSA-9024909", "R-HSA-9034864", "R-MMU-1257604", "R-HSA-2219530", "R-HSA-9032500", "R-HSA-6811558", "R-HSA-177504", "R-HSA-9034013", "R-RNO-9032759", "R-HSA-187024", "R-HSA-187706", "R-MMU-177504", "R-HSA-170968", "R-MMU-9032759", "R-MMU-170984", "R-RNO-388844", "R-HSA-1257604", "R-RNO-9028731", "R-GGA-388844", "R-HSA-198203", "R-MMU-9026527"], "pathways": ["R-HSA-167044:r:Signalling to RAS", "R-HSA-187042:r:TRKA activation by NGF", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-HSA-198745:r:Signalling to STAT3", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-198203:r:PI3K/AKT activation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-187042:r:TRKA activation by NGF", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-RNO-170968:r:Frs2-mediated activation", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-170984:r:ARMS-mediated activation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-HSA-170968:r:Frs2-mediated activation", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-170984:r:ARMS-mediated activation", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-198203:r:PI3K/AKT activation", "R-MMU-9026527:r:Activated NTRK2 signals 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"R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CFA-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CFA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR020794": {"description": "Phosphomevalonate dehydratase small subunit", "go_ids": [], "go_terms": [], "name": "PMDh_S", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020795": {"description": "Origin recognition complex, subunit 3", "go_ids": ["GO:0003677", "GO:0005664", "GO:0006260"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005664:nuclear origin of replication recognition complex:C", "GO:0006260:DNA replication:P"], "name": "ORC3", "pathway_ids": ["R-DDI-68689", "R-RNO-68949", "R-SPO-176187", "R-HSA-68949", "R-SPO-68616", "R-RNO-68962", "R-MMU-68962", "R-HSA-113507", "R-HSA-68867", "R-MMU-68949", "R-RNO-176187", "R-HSA-68689", "R-SCE-68962", "R-SCE-68616", "R-HSA-68616", "R-RNO-68616", "R-DDI-68962", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949", "R-SCE-176187", "R-HSA-176187", "R-RNO-68689", "R-DDI-68616"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin 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pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication"], "type": "Family"}, "IPR020796": {"description": "Origin recognition complex, subunit 5", "go_ids": ["GO:0000808", "GO:0005634", "GO:0006260"], "go_terms": ["GO:0000808:origin recognition complex:C", "GO:0005634:nucleus:C", "GO:0006260:DNA replication:P"], "name": "ORC5", "pathway_ids": ["R-DDI-68689", "R-SPO-176187", "R-HSA-68949", "R-SPO-68616", "R-MMU-68962", "R-HSA-113507", "R-MMU-68949", "R-DDI-68616", "R-HSA-68689", "R-SCE-68962", "R-DME-68616", "R-SCE-68616", "R-HSA-68616", "R-DME-68689", "R-DME-68962", "R-DDI-68962", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-DME-176187", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949", "R-SCE-176187", "R-HSA-176187", "R-DME-68949", "R-HSA-68867"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Family"}, "IPR020799": {"description": "A-kinase anchor 110kDa", "go_ids": [], "go_terms": [], "name": "AKAP_110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020802": {"description": "Thioesterase TesA-like", "go_ids": ["GO:0009058"], "go_terms": ["GO:0009058:biosynthetic process:P"], "name": "TesA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020803": {"description": "Polyketide synthase-like, methyltransferase domain", "go_ids": [], "go_terms": [], "name": "MeTfrase_dom", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR020806": {"description": "Polyketide synthase-like, phosphopantetheine-binding domain", "go_ids": ["GO:0031177"], "go_terms": ["GO:0031177:phosphopantetheine binding:F"], "name": "PKS_PP-bd", "pathway_ids": ["R-HSA-163765", "R-HSA-9029558", "R-HSA-75105", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR020807": {"description": "Polyketide/metazoan fatty acid synthase-like, dehydratase domain", "go_ids": [], "go_terms": [], "name": "PKS_DH", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-HSA-75105", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR020810": {"description": "Enolase, C-terminal TIM barrel domain", "go_ids": [], "go_terms": [], "name": "Enolase_C", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-2221", "PWY-1622", "PWY-7124", "PWY-6886", "PWY-6142", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-MMU-70171", "R-DRE-70263", "R-SCE-70171", "R-BTA-70171", "R-DME-70171", "R-PFA-70263", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-DME-70263", "R-DDI-70263", "R-PFA-70171", "R-RNO-70171", "R-GGA-352882", "R-HSA-70263", "R-CEL-70263", "R-BTA-70263", "R-SPO-70263", "R-SCE-70263", "R-DRE-70171", "R-HSA-9636667", "R-HSA-70171", "R-SPO-70171", "R-RNO-70263"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-DRE-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-PFA-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-PFA-70171:r:Glycolysis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-DRE-70171:r:Glycolysis", "R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR020811": {"description": "Enolase, N-terminal", "go_ids": [], "go_terms": [], "name": "Enolase_N", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-2221", "PWY-1622", "PWY-7124", "PWY-6886", "PWY-6142", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-MMU-70171", "R-DRE-70263", "R-SCE-70171", "R-BTA-70171", "R-DME-70171", "R-PFA-70263", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-DME-70263", "R-DDI-70263", "R-PFA-70171", "R-RNO-70171", "R-GGA-352882", "R-HSA-70263", "R-CEL-70263", "R-BTA-70263", "R-SPO-70263", "R-SCE-70263", "R-DRE-70171", "R-HSA-9636667", "R-HSA-70171", "R-SPO-70171", "R-RNO-70263"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-DRE-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-PFA-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-PFA-70171:r:Glycolysis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-DRE-70171:r:Glycolysis", "R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR020818": {"description": "GroES chaperonin family", "go_ids": ["GO:0044183", "GO:0006457", "GO:0005524"], "go_terms": ["GO:0044183:protein folding chaperone:F", "GO:0006457:protein folding:P", "GO:0005524:ATP binding:F"], "name": "Chaperonin_GroES", "pathway_ids": ["R-BTA-9013408", "R-HSA-9841251", "R-RNO-9013408", "R-MMU-9013408", "R-HSA-9013408"], "pathways": ["R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-9013408:r:RHOG GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle"], "type": "Family"}, "IPR020821": {"description": "ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain", "go_ids": ["GO:0003676", "GO:0016787", "GO:0046872"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0016787:hydrolase activity:F", "GO:0046872:metal ion binding:F"], "name": "ENPP1-3/EXOG-like_nuc-like", "pathway_ids": ["R-RNO-196843", "R-HSA-114608", "R-HSA-199220", "R-MMU-196843", "R-HSA-196843", "R-MMU-114608", "R-HSA-9913635"], "pathways": ["R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-114608:r:Platelet degranulation", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR020823": {"description": "Cell division protein FtsA", "go_ids": [], "go_terms": [], "name": "Cell_div_FtsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020825": {"description": "Phenylalanyl-tRNA synthetase-like, B3/B4", "go_ids": [], "go_terms": [], "name": "Phe-tRNA_synthase-like_B3/B4", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR020828": {"description": "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain", "go_ids": ["GO:0051287"], "go_terms": ["GO:0051287:NAD binding:F"], "name": "GlycerAld_3-P_DH_NAD(P)-bd", "pathway_ids": ["R-MMU-70171", "R-DRE-70263", "R-RNO-70263", "R-SCE-70171", "R-HSA-390471", "R-BTA-70171", "R-DME-70171", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-GGA-70171", "R-DME-70263", "R-DDI-70263", "R-GGA-70263", "R-RNO-70171", "R-GGA-352882", "R-CEL-70263", "R-HSA-70263", "R-BTA-70263", "R-SCE-70263", "R-DRE-70171", "R-HSA-70171", "R-SPO-70171", "R-SPO-70263"], "pathways": ["R-MMU-70171:r:Glycolysis", "R-DRE-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-GGA-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-GGA-70263:r:Gluconeogenesis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-CEL-70263:r:Gluconeogenesis", "R-HSA-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-DRE-70171:r:Glycolysis", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR020829": {"description": "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain", "go_ids": ["GO:0016620"], "go_terms": ["GO:0016620:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor:F"], "name": "GlycerAld_3-P_DH_cat", "pathway_ids": ["R-MMU-70171", "R-DRE-70263", "R-RNO-70263", "R-SCE-70171", "R-HSA-390471", "R-BTA-70171", "R-DME-70171", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-GGA-70171", "R-DME-70263", "R-DDI-70263", "R-GGA-70263", "R-RNO-70171", "R-GGA-352882", "R-CEL-70263", "R-HSA-70263", "R-BTA-70263", "R-SCE-70263", "R-DRE-70171", "R-HSA-70171", "R-SPO-70171", "R-SPO-70263"], "pathways": ["R-MMU-70171:r:Glycolysis", "R-DRE-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-GGA-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-GGA-70263:r:Gluconeogenesis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-CEL-70263:r:Gluconeogenesis", "R-HSA-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-DRE-70171:r:Glycolysis", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR020831": {"description": "Glyceraldehyde/Erythrose phosphate dehydrogenase family", "go_ids": ["GO:0016620"], "go_terms": ["GO:0016620:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor:F"], "name": "GlycerAld/Erythrose_P_DH", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-MMU-70171", "R-DRE-70263", "R-RNO-70263", "R-SCE-70171", "R-HSA-390471", "R-BTA-70171", "R-DME-70171", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-GGA-70171", "R-DME-70263", "R-DDI-70263", "R-GGA-70263", "R-RNO-70171", "R-GGA-352882", "R-CEL-70263", "R-HSA-70263", "R-BTA-70263", "R-SCE-70263", "R-DRE-70171", "R-HSA-70171", "R-SPO-70171", "R-SPO-70263"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-DRE-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-GGA-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-GGA-70263:r:Gluconeogenesis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-CEL-70263:r:Gluconeogenesis", "R-HSA-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-DRE-70171:r:Glycolysis", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Family"}, "IPR020835": {"description": "Catalase superfamily", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "Catalase_sf", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-HSA-3299685", "R-SPO-6798695", "R-DRE-3299685", "R-CFA-9033241", "R-DME-6798695", "R-DME-9033241", "R-SCE-6798695", "R-HSA-9841251", "R-BTA-6798695", "R-MMU-9033241", "R-MMU-3299685", "R-RNO-3299685", "R-BTA-9033241", "R-DDI-3299685", "R-RNO-9033241", "R-SCE-3299685", "R-SPO-9033241", "R-HSA-9615017", "R-BTA-3299685", "R-SPO-3299685", "R-DRE-6798695", "R-CFA-3299685", "R-SCE-9033241", "R-MMU-6798695", "R-CFA-6798695", "R-DME-3299685", "R-DDI-9033241", "R-HSA-9033241", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-3299685:r:Detoxification of Reactive Oxygen Species", "R-CFA-9033241:r:Peroxisomal protein import", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-9033241:r:Peroxisomal protein import", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9033241:r:Peroxisomal protein import", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-9033241:r:Peroxisomal protein import", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-DRE-6798695:r:Neutrophil degranulation", "R-CFA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SCE-9033241:r:Peroxisomal protein import", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-6798695:r:Neutrophil degranulation", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR020838": {"description": "DBINO domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "DBINO", "pathway_ids": ["PWY-7250", "R-MMU-5696394", "R-MMU-5689603", "R-HSA-5689603", "R-DME-5689603", "R-DME-5696394", "R-HSA-5696394"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Domain"}, "IPR020839": {"description": "Stromalin conservative domain", "go_ids": [], "go_terms": [], "name": "SCD", "pathway_ids": ["R-SCE-3108214", "R-HSA-2468052", "R-MMU-2500257", "R-SPO-2500257", "R-SCE-2468052", "R-SPO-3108214", "R-SPO-2470946", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-3108214", "R-MMU-2467813", "R-CEL-2470946", "R-HSA-2470946", "R-HSA-1221632", "R-SCE-2500257", "R-CEL-3108214", "R-MMU-3108214", "R-CEL-2468052", "R-MMU-2468052", "R-MMU-2470946", "R-HSA-9018519", "R-CEL-2500257"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-1221632:r:Meiotic synapsis", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion"], "type": "Domain"}, "IPR020840": {"description": "Extracellular matrix-binding protein ebh, GA module", "go_ids": [], "go_terms": [], "name": "Extracell_matrix-bd_GA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020841": {"description": "Polyketide synthase, beta-ketoacyl synthase domain", "go_ids": [], "go_terms": [], "name": "PKS_Beta-ketoAc_synthase_dom", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-MMU-9837999", "R-DDI-75105", "R-SPO-9837999", "R-HSA-75105", "R-SCE-9837999", "R-DDI-199220", "R-HSA-9918487", "R-HSA-9837999", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR020843": {"description": "Enoylreductase domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "ER", "pathway_ids": ["R-GGA-5365859", "R-GGA-71384", "R-HSA-9029558", "R-HSA-2142700", "R-RNO-5661270", "R-HSA-2142691", "R-HSA-6798695", "R-RNO-77346", "R-DDI-75105", "R-MMU-2161541", "R-DRE-77346", "R-RNO-2161541", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-2161541", "R-HSA-199220", "R-HSA-6803205", "R-MMU-199220", "R-RNO-199220", "R-HSA-77346", "R-SPO-5661270", "R-HSA-5661270", "R-MMU-77346", "R-SCE-5652227", "R-BTA-71384", "R-DRE-6798695", "R-MMU-5661270", "R-DDI-199220", "R-SPO-77346", "R-HSA-9918481", "R-CEL-77346", "R-MMU-5652227", "R-DME-77346", "R-SPO-5365859", "R-HSA-163765", "R-SPO-5652227", "R-GGA-2161541", "R-RNO-5365859", "R-SPO-2161541", "R-BTA-5652227", "R-SCE-5661270", "R-RNO-5652227", "R-HSA-5365859", "R-RNO-71384", "R-DDI-77346", "R-HSA-71384", "R-MMU-75105", "R-SPO-71384", "R-MMU-5365859", "R-BTA-5661270", "R-HSA-75105", "R-MMU-6798695", "R-HSA-5652227", "R-HSA-2426168", "R-RNO-6798695", "R-XTR-77346", "R-MMU-71384"], "pathways": ["R-GGA-5365859:r:RA biosynthesis pathway", "R-GGA-71384:r:Ethanol oxidation", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-2161541:r:Abacavir metabolism", "R-DRE-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-2161541:r:Abacavir metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-2161541:r:Abacavir metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SPO-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SCE-5652227:r:Fructose biosynthesis", "R-BTA-71384:r:Ethanol oxidation", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SPO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-5652227:r:Fructose biosynthesis", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SPO-5365859:r:RA biosynthesis pathway", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-SPO-5652227:r:Fructose biosynthesis", "R-GGA-2161541:r:Abacavir metabolism", "R-RNO-5365859:r:RA biosynthesis pathway", "R-SPO-2161541:r:Abacavir metabolism", "R-BTA-5652227:r:Fructose biosynthesis", "R-SCE-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-5652227:r:Fructose biosynthesis", "R-HSA-5365859:r:RA biosynthesis pathway", "R-RNO-71384:r:Ethanol oxidation", "R-DDI-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-71384:r:Ethanol oxidation", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-SPO-71384:r:Ethanol oxidation", "R-MMU-5365859:r:RA biosynthesis pathway", "R-BTA-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5652227:r:Fructose biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-6798695:r:Neutrophil degranulation", "R-XTR-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-71384:r:Ethanol oxidation"], "type": "Domain"}, "IPR020849": {"description": "Small GTPase, Ras-type", "go_ids": ["GO:0005525", "GO:0007165", "GO:0016020"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0007165:signal transduction:P", "GO:0016020:membrane:C"], "name": "Small_GTPase_Ras-type", "pathway_ids": ["R-DRE-5654699", "R-MMU-180336", "R-RNO-1250347", "R-HSA-6802952", "R-RNO-372708", "R-SSC-9607240", "R-HSA-2871796", "R-MMU-1632852", "R-DRE-1250347", "R-HSA-9027284", "R-GGA-354192", "R-RNO-416550", "R-GGA-5675221", "R-CEL-9607240", "R-GGA-2179392", "R-CEL-9639288", "R-CEL-4086398", "R-RNO-375165", "R-HSA-6802955", "R-SCE-9696273", "R-MMU-186763", "R-MMU-8849471", "R-CEL-1169092", "R-BTA-354194", "R-HSA-170984", "R-DDI-9634635", "R-DDI-6798695", "R-GGA-5673001", "R-DME-9607240", "R-RNO-165159", "R-HSA-6802948", "R-MMU-170968", "R-GGA-375165", "R-MMU-392517", "R-BTA-381676", "R-DRE-1169092", "R-MMU-5673000", "R-DDI-5673001", "R-DRE-186763", "R-RNO-5675221", "R-CEL-5674135", "R-DRE-5673000", "R-GGA-9607240", "R-HSA-5654700", "R-MMU-171007", "R-DDI-5674135", "R-CEL-1433557", "R-CEL-8851805", "R-MMU-179812", "R-BTA-8875555", 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"R-SPO-9696273", "R-DRE-1963640", "R-HSA-9753512", "R-SSC-180336", "R-MMU-5628897", "R-BTA-392517", "R-HSA-9664565", "R-HSA-5655302", "R-CEL-5654693", "R-XTR-392517", "R-RNO-5654693", "R-DRE-5654706", "R-HSA-9665686", "R-DDI-5658442", "R-XTR-8875555", "R-HSA-8950505", "R-DDI-380972", "R-MMU-5654700", "R-DME-5654688", "R-GGA-5621575", "R-DME-354192", "R-BTA-170968", "R-DRE-210993", "R-GGA-6798695", "R-MMU-9634635", "R-MMU-8875555", "R-GGA-1169092", "R-SPO-165159", "R-HSA-5658442", "R-HSA-9703648", "R-DRE-5658442", "R-HSA-381676", "R-RNO-380972", "R-DME-1963640", "R-RNO-8875555", "R-HSA-9674555", "R-MMU-5654688", "R-HSA-372708", "R-HSA-5654704", "R-SSC-171007", "R-SCE-392517", "R-DME-5628897", "R-MMU-375165", "R-CEL-375165", "R-GGA-5654719", "R-MMU-1169092", "R-RNO-8943724", "R-CEL-1632852", "R-DDI-8849471", "R-RNO-354194", "R-HSA-5628897", "R-GGA-2424491", "R-MMU-372708", "R-DDI-381676", "R-CEL-8943724", "R-HSA-6802946", "R-HSA-1236382", "R-GGA-180336", "R-RNO-9648002", "R-DME-381676", "R-MMU-5654719", "R-RNO-170984", "R-DRE-5654693", "R-SSC-5658442", "R-HSA-9028731", "R-HSA-171007", "R-HSA-354192", "R-SSC-8849471", "R-GGA-171007", "R-GGA-2871796", "R-DDI-171007", "R-GGA-5654699", "R-RNO-1963640", "R-CEL-392517", "R-RNO-9634635", "R-HSA-354194", "R-HSA-1433557", "R-CEL-381676", "R-CEL-180336", "R-DDI-5621575", "R-HSA-9703465", "R-RNO-5218921", "R-DRE-392517", "R-DRE-9607240", "R-RNO-5658442", "R-GGA-5654688", "R-MMU-166208", "R-MMU-2424491", "R-DME-8849471", "R-DRE-5654688", "R-DRE-5654719", "R-SSC-8851805", "R-SSC-5654688", "R-RNO-186763", "R-HSA-9696273", "R-CEL-5654704", "R-HSA-5675221"], "pathways": ["R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-SSC-9607240:r:FLT3 Signaling", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-1632852:r:Macroautophagy", "R-DRE-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-GGA-354192:r:Integrin signaling", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-CEL-9607240:r:FLT3 Signaling", "R-GGA-2179392:r:EGFR Transactivation by Gastrin", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-CEL-4086398:r:Ca2+ pathway", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SCE-9696273:r:RND1 GTPase cycle", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CEL-1169092:r:Activation of RAS in B cells", "R-BTA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-170984:r:ARMS-mediated activation", "R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DDI-6798695:r:Neutrophil degranulation", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-DME-9607240:r:FLT3 Signaling", "R-RNO-165159:r:MTOR signalling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-170968:r:Frs2-mediated activation", "R-GGA-375165:r:NCAM signaling for neurite out-growth", "R-MMU-392517:r:Rap1 signalling", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DRE-1169092:r:Activation of RAS in B cells", "R-MMU-5673000:r:RAF activation", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-DRE-186763:r:Downstream signal transduction", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-DRE-5673000:r:RAF activation", "R-GGA-9607240:r:FLT3 Signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-171007:r:p38MAPK events", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-8851805:r:MET activates RAS signaling", 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Metabolic Genes", "R-GGA-2424491:r:DAP12 signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-GGA-180336:r:SHC1 events in EGFR signaling", "R-RNO-9648002:r:RAS processing", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-170984:r:ARMS-mediated activation", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-SSC-5658442:r:Regulation of RAS by GAPs", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-171007:r:p38MAPK events", "R-HSA-354192:r:Integrin signaling", "R-SSC-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-GGA-171007:r:p38MAPK events", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-DDI-171007:r:p38MAPK events", "R-GGA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-392517:r:Rap1 signalling", "R-RNO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-392517:r:Rap1 signalling", "R-DRE-9607240:r:FLT3 Signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-GGA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-166208:r:mTORC1-mediated signalling", "R-MMU-2424491:r:DAP12 signaling", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-SSC-8851805:r:MET activates RAS signaling", "R-SSC-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR020856": {"description": "Circadian clock oscillator protein KaiA, C-terminal", "go_ids": ["GO:0006468", "GO:0007623"], "go_terms": ["GO:0006468:protein phosphorylation:P", "GO:0007623:circadian rhythm:P"], "name": "Circadian_clock_protein_KaiA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020858": {"description": "Serum albumin-like", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Serum_albumin-like", "pathway_ids": ["R-RNO-189451", "R-HSA-9757110", "R-HSA-2168880", "R-MMU-8957275", "R-HSA-189483", "R-RNO-114608", "R-RNO-9757110", "R-BTA-8957275", "R-HSA-114608", "R-HSA-196791", "R-RNO-9793528", "R-MMU-189483", "R-RNO-159418", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-9707564", "R-MMU-9749641", "R-RNO-189483", "R-RNO-8964058", "R-MMU-8964058", "R-HSA-381426", "R-MMU-2168880", "R-SSC-381426", "R-SSC-8957275", "R-MMU-189451", "R-HSA-8964058", "R-MMU-9757110", "R-RNO-2168880", "R-RNO-9707564", "R-MMU-9793528", "R-HSA-189451", "R-RNO-381426", "R-RNO-196791", "R-MMU-196791", "R-HSA-9749641", "R-HSA-9793528", "R-RNO-9749641", "R-HSA-8957275", "R-HSA-159418", "R-MMU-159418", "R-MMU-9707564", "R-MMU-114608"], "pathways": ["R-RNO-189451:r:Heme biosynthesis", "R-HSA-9757110:r:Prednisone ADME", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-189483:r:Heme degradation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-9757110:r:Prednisone ADME", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-MMU-189483:r:Heme degradation", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-189483:r:Heme degradation", "R-RNO-8964058:r:HDL remodeling", "R-MMU-8964058:r:HDL remodeling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-189451:r:Heme biosynthesis", "R-HSA-8964058:r:HDL remodeling", "R-MMU-9757110:r:Prednisone ADME", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-HSA-189451:r:Heme biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-RNO-9749641:r:Aspirin ADME", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-159418:r:Recycling of bile acids and salts", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR020864": {"description": "Membrane attack complex component/perforin (MACPF) domain", "go_ids": [], "go_terms": [], "name": "MACPF", "pathway_ids": ["R-BTA-166665", "R-HSA-9725371", "R-RNO-166665", "R-MMU-977606", "R-HSA-166665", "R-HSA-977606", "R-RNO-977606", "R-MMU-166665", "R-BTA-977606"], "pathways": ["R-BTA-166665:r:Terminal pathway of complement", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-RNO-166665:r:Terminal pathway of complement", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-166665:r:Terminal pathway of complement", "R-BTA-977606:r:Regulation of Complement cascade"], "type": "Domain"}, "IPR020868": {"description": "Bifunctional enzyme Fae/Hps", "go_ids": ["GO:0016051", "GO:0016832", "GO:0016840"], "go_terms": ["GO:0016051:carbohydrate biosynthetic process:P", "GO:0016832:aldehyde-lyase activity:F", "GO:0016840:carbon-nitrogen lyase activity:F"], "name": "Fae/Hps", "pathway_ids": ["PWY-1861", "PWY-1723", "PWY-7796"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1723:t:formaldehyde oxidation VI (H4MPT pathway)", "PWY-7796:t:pentose phosphate pathway (oxidative branch) II"], "type": "Family"}, "IPR020869": {"description": "Exosome complex component Rrp42, archaea", "go_ids": ["GO:0006401", "GO:0000178"], "go_terms": ["GO:0006401:RNA catabolic process:P", "GO:0000178:exosome (RNase complex):C"], "name": "Rrp42_archaea", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020870": {"description": "Uncharacterised protein family UPF0387, membrane", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "UPF0387_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020872": {"description": "2-phosphoglycerate kinase", "go_ids": ["GO:0016774"], "go_terms": ["GO:0016774:phosphotransferase activity, carboxyl group as acceptor:F"], "name": "2PKG", "pathway_ids": ["PWY-8098"], "pathways": ["PWY-8098:t:cyclic 2,3-bisphosphoglycerate biosynthesis"], "type": "Family"}, "IPR020874": {"description": "NAD(P)H-quinone oxidoreductase, subunit N", "go_ids": ["GO:0016655", "GO:0016020"], "go_terms": ["GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F", "GO:0016020:membrane:C"], "name": "NAD(P)H-quinone_OxRdtase_su_N", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020876": {"description": "Tyrosine recombinase XerD-like", "go_ids": ["GO:0005737"], "go_terms": ["GO:0005737:cytoplasm:C"], "name": "Tyrosine_recombinase_XerD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020883": {"description": "Type I toxin-antitoxin system, SymE toxin", "go_ids": ["GO:0004521", "GO:0005737", "GO:0003723", "GO:0016070"], "go_terms": ["GO:0004521:RNA endonuclease activity:F", "GO:0005737:cytoplasm:C", "GO:0003723:RNA binding:F", "GO:0016070:RNA metabolic process:P"], "name": "TypeI_TA_SymE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020884": {"description": "Glutathione-regulated potassium-efflux system protein KefB", "go_ids": ["GO:0005886", "GO:0006813", "GO:0015503"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0006813:potassium ion transport:P", "GO:0015503:glutathione-regulated potassium exporter activity:F"], "name": "K_H_efflux_KefB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020885": {"description": "UPF0367", "go_ids": [], "go_terms": [], "name": "UPF0367", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020887": {"description": "Uncharacterised protein family UPF0509", "go_ids": [], "go_terms": [], "name": "UPF0509", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020897": {"description": "Synapsin, pre-ATP-grasp domain", "go_ids": [], "go_terms": [], "name": "Synapsin_pre-ATP-grasp_dom", "pathway_ids": ["R-HSA-181429", "R-RNO-212676", "R-MMU-212676", "R-HSA-9662360", "R-DME-181429", "R-RNO-181429", "R-MMU-181429", "R-HSA-212676", "R-DME-212676"], "pathways": ["R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle"], "type": "Domain"}, "IPR020898": {"description": "Synapsin, ATP-binding domain", "go_ids": [], "go_terms": [], "name": "Synapsin_ATP-bd_dom", "pathway_ids": ["R-HSA-181429", "R-RNO-212676", "R-MMU-212676", "R-HSA-9662360", "R-DME-181429", "R-RNO-181429", "R-MMU-181429", "R-HSA-212676", "R-DME-212676"], "pathways": ["R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle"], "type": "Domain"}, "IPR020899": {"description": "Arginine repressor, C-terminal", "go_ids": ["GO:0034618", "GO:0051259"], "go_terms": ["GO:0034618:arginine binding:F", "GO:0051259:protein complex oligomerization:P"], "name": "Arg_repress_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020900": {"description": "Arginine repressor, DNA-binding domain", "go_ids": ["GO:0003700", "GO:0006355", "GO:0006525"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0006525:arginine metabolic process:P"], "name": "Arg_repress_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020905": {"description": "NAD(P)H-quinone oxidoreductase subunit O", "go_ids": ["GO:0016655", "GO:0005886"], "go_terms": ["GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F", "GO:0005886:plasma membrane:C"], "name": "NdhO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020906": {"description": "Double-stranded DNA-binding Cren7", "go_ids": ["GO:0005737", "GO:0003690"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0003690:double-stranded DNA binding:F"], "name": "dsDNA-bd_Cren7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020907": {"description": "PhoP/PhoQ regulator MgrB", "go_ids": [], "go_terms": [], "name": "MgrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020908": {"description": "Uncharacterised protein family UPF0738", "go_ids": [], "go_terms": [], "name": "UPF0738", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020909": {"description": "UPF0736", "go_ids": [], "go_terms": [], "name": "UPF0736", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020910": {"description": "Uncharacterised protein family UPF0370", "go_ids": [], "go_terms": [], "name": "UPF0370", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020911": {"description": "Uncharacterised protein family UPF0325", "go_ids": [], "go_terms": [], "name": "UPF0325", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020912": {"description": "Uncharacterised protein family UPF0295", "go_ids": [], "go_terms": [], "name": "UPF0295", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020914": {"description": "Probable succinate transporter subunit YjjB", "go_ids": [], "go_terms": [], "name": "YjjB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020915": {"description": "Uncharacterised protein family UPF0311", "go_ids": [], "go_terms": [], "name": "UPF0311", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020916": {"description": "Protein-glutamine gamma-glutamyltransferase, bacteria", "go_ids": ["GO:0003810"], "go_terms": ["GO:0003810:protein-glutamine gamma-glutamyltransferase activity:F"], "name": "Gln_gamma-glutamylTfrase_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020917": {"description": "Primosomal protein 1", "go_ids": ["GO:0006260", "GO:1990077"], "go_terms": ["GO:0006260:DNA replication:P", "GO:1990077:primosome complex:C"], "name": "DnaT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020920": {"description": "L-lactate dehydrogenase, bacterial", "go_ids": ["GO:0004457", "GO:0010181", "GO:0006089"], "go_terms": ["GO:0004457:lactate dehydrogenase activity:F", "GO:0010181:FMN binding:F", "GO:0006089:lactate metabolic process:P"], "name": "LldD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020923": {"description": "DNA ligase B", "go_ids": ["GO:0006259", "GO:0003911", "GO:0006260"], "go_terms": ["GO:0006259:DNA metabolic process:P", "GO:0003911:DNA ligase (NAD+) activity:F", "GO:0006260:DNA replication:P"], "name": "DNA_ligase_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020930": {"description": "Large ribosomal subunit protein uL5, bacteria", "go_ids": ["GO:0006412", "GO:0003735", "GO:0005840"], "go_terms": ["GO:0006412:translation:P", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C"], "name": "Ribosomal_uL5_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020931": {"description": "Decarboxylase MfnA, archaea", "go_ids": ["GO:0016831"], "go_terms": ["GO:0016831:carboxy-lyase activity:F"], "name": "MfnA", "pathway_ids": ["PWY-7297", "PWY-5254", "PWY-5474", "PWY-6802", "PWY-5155", "PWY-6133", "PWY-7826", "PWY-3581"], "pathways": ["PWY-7297:t:octopamine biosynthesis", "PWY-5254:t:methanofuran biosynthesis", "PWY-5474:t:hydroxycinnamic acid tyramine amides biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-5155:t:beta-alanine biosynthesis III", "PWY-6133:t:(S)-reticuline biosynthesis II", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-3581:t:(S)-reticuline biosynthesis I"], "type": "Family"}, "IPR020936": {"description": "tRNA uridine(34) hydroxylase", "go_ids": [], "go_terms": [], "name": "TrhO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020941": {"description": "Suppressor of fused-like domain", "go_ids": [], "go_terms": [], "name": "SUFU-like_domain", "pathway_ids": ["R-HSA-5610780", "R-MMU-5610780", "R-HSA-5610785", "R-MMU-5632684", "R-MMU-5610785", "R-HSA-5610787", "R-MMU-5610787", "R-HSA-5610783", "R-HSA-5632684"], "pathways": ["R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-5632684:r:Hedgehog 'on' state"], "type": "Domain"}, "IPR020942": {"description": "Class III cytochrome C", "go_ids": ["GO:0009055", "GO:0020037"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0020037:heme binding:F"], "name": "Cyt_c_III_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020944": {"description": "Nodulation protein S", "go_ids": ["GO:0009312", "GO:0008757"], "go_terms": ["GO:0009312:oligosaccharide biosynthetic process:P", "GO:0008757:S-adenosylmethionine-dependent methyltransferase activity:F"], "name": "NodS", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR020945": {"description": "DMSO/Nitrate reductase chaperone", "go_ids": [], "go_terms": [], "name": "DMSO/NO3_reduct_chaperone", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020946": {"description": "Flavin monooxygenase-like", "go_ids": ["GO:0004499", "GO:0050660", "GO:0050661"], "go_terms": ["GO:0004499:N,N-dimethylaniline monooxygenase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0050661:NADP binding:F"], "name": "Flavin_mOase-like", "pathway_ids": ["R-MMU-1614558", "R-MMU-217271", "R-CFA-1614558", "R-RNO-1614558", "R-HSA-1614558", "R-SSC-1614558", "R-HSA-5579019", "R-HSA-217271", "R-RNO-217271", "R-CFA-217271", "R-BTA-217271", "R-SSC-217271"], "pathways": ["R-MMU-1614558:r:Degradation of cysteine and homocysteine", "R-MMU-217271:r:FMO oxidises nucleophiles", "R-CFA-1614558:r:Degradation of cysteine and homocysteine", "R-RNO-1614558:r:Degradation of cysteine and homocysteine", "R-HSA-1614558:r:Degradation of cysteine and homocysteine", "R-SSC-1614558:r:Degradation of cysteine and homocysteine", "R-HSA-5579019:r:Defective FMO3 causes TMAU", "R-HSA-217271:r:FMO oxidises nucleophiles", "R-RNO-217271:r:FMO oxidises nucleophiles", "R-CFA-217271:r:FMO oxidises nucleophiles", "R-BTA-217271:r:FMO oxidises nucleophiles", "R-SSC-217271:r:FMO oxidises nucleophiles"], "type": "Family"}, "IPR020948": {"description": "Phosphate-starvation-induced PsiE-like", "go_ids": [], "go_terms": [], "name": "P_starv_induced_PsiE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020949": {"description": "Prion, copper binding octapeptide repeat region", "go_ids": [], "go_terms": [], "name": "Prion_copper_b_octapeptide", "pathway_ids": ["R-RNO-9609523", "R-MMU-9609523", "R-HSA-419037", "R-HSA-9609523"], "pathways": ["R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Repeat"}, "IPR020951": {"description": "Mitochondrial import receptor subunit Tom22, fungi", "go_ids": ["GO:0005741", "GO:0005742", "GO:0030150"], "go_terms": ["GO:0005741:mitochondrial outer membrane:C", "GO:0005742:mitochondrial outer membrane translocase complex:C", "GO:0030150:protein import into mitochondrial matrix:P"], "name": "Tom22_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020952": {"description": "Antitermination protein N, arginine-rich motif", "go_ids": [], "go_terms": [], "name": "Antiterm_prot_N_Arg-rich", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020954": {"description": "Antigenic heat-stable 120 kDa protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Sca4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020955": {"description": "Uncharacterised protein family Atu4866", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Atu4866", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020956": {"description": "Transcription factor Aft1, osmotic stress domain", "go_ids": [], "go_terms": [], "name": "TF_Aft1_OSM", "pathway_ids": ["R-SCE-3214847", "R-SCE-450341", "R-SPO-450341", "R-SPO-3214847"], "pathways": ["R-SCE-3214847:r:HATs acetylate histones", "R-SCE-450341:r:Activation of the AP-1 family of transcription factors", "R-SPO-450341:r:Activation of the AP-1 family of transcription factors", "R-SPO-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR020957": {"description": "Tachystatin B", "go_ids": [], "go_terms": [], "name": "Tachystatin_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020958": {"description": "Domain of unknown function DUF3686", "go_ids": [], "go_terms": [], "name": "DUF3686", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020959": {"description": "Arabinofuranosyltransferase AftA, C-terminal", "go_ids": ["GO:0016020", "GO:0005886", "GO:0016757", "GO:0044038"], "go_terms": ["GO:0016020:membrane:C", "GO:0005886:plasma membrane:C", "GO:0016757:glycosyltransferase activity:F", "GO:0044038:cell wall macromolecule biosynthetic process:P"], "name": "ArabinofuranosylTrfase_AftA_C", "pathway_ids": ["PWY-6397"], "pathways": ["PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"], "type": "Domain"}, "IPR020960": {"description": "Aleutian mink disease parvovirus non-structural protein 1-3", "go_ids": [], "go_terms": [], "name": "ADV_NS1-3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020961": {"description": "Domain of unknown function DUF3642, lipoprotein", "go_ids": [], "go_terms": [], "name": "DUF3642_lipo", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020962": {"description": "Bacteriophage phiX174, GpK", "go_ids": [], "go_terms": [], "name": "Phage_phiX174_GpK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020963": {"description": "Arabinofuranosyltransferase AftA, N-terminal", "go_ids": ["GO:0016020", "GO:0005886", "GO:0016757", "GO:0044038"], "go_terms": ["GO:0016020:membrane:C", "GO:0005886:plasma membrane:C", "GO:0016757:glycosyltransferase activity:F", "GO:0044038:cell wall macromolecule biosynthetic process:P"], "name": "ArabinofuranosylTrfase_AftA_N", "pathway_ids": ["PWY-6397"], "pathways": ["PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"], "type": "Domain"}, "IPR020964": {"description": "Acyl-CoA dehydrogenase, C-terminal", "go_ids": [], "go_terms": [], "name": "Acyl-CoA_dehydrogenase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020965": {"description": "Aromatic prenyltransferase, CloQ-type", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "Prenyltransferase_CloQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020966": {"description": "Aluminum-activated malate transporter", "go_ids": [], "go_terms": [], "name": "ALMT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020967": {"description": "Borrelia attachment ligand, p66", "go_ids": [], "go_terms": [], "name": "Borrelia_attachment_p66", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020968": {"description": "Bacteriocin class II, aureocin-like", "go_ids": [], "go_terms": [], "name": "Bacteriocin_II_aureocin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020969": {"description": "Ankyrin-G binding site", "go_ids": ["GO:0016020", "GO:0005267"], "go_terms": ["GO:0016020:membrane:C", "GO:0005267:potassium channel activity:F"], "name": "Ankyrin-G_BS", "pathway_ids": ["R-HSA-1296072", "R-HSA-445095", "R-BTA-1296072"], "pathways": ["R-HSA-1296072:r:Voltage gated Potassium channels", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-BTA-1296072:r:Voltage gated Potassium channels"], "type": "Binding_site"}, "IPR020970": {"description": "Bacteriocin class IIc", "go_ids": [], "go_terms": [], "name": "Bacteriocin_IIc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020971": {"description": "ATP synthase, F1 beta subunit", "go_ids": ["GO:0005524", "GO:0016887", "GO:0006754", "GO:0045259"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0016887:ATP hydrolysis activity:F", "GO:0006754:ATP biosynthetic process:P", "GO:0045259:proton-transporting ATP synthase complex:C"], "name": "ATP_synth_F1_beta_su", "pathway_ids": ["PWY-7980"], "pathways": ["PWY-7980:t:ATP biosynthesis"], "type": "Domain"}, "IPR020972": {"description": "Dermonecrotic/RTX toxin, membrane localization domain", "go_ids": [], "go_terms": [], "name": "Dermonecrotic/RTX_toxin_MLD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020973": {"description": "Packaging enzyme P4", "go_ids": ["GO:0019072"], "go_terms": ["GO:0019072:viral genome packaging:P"], "name": "Packaging_enz_P4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020974": {"description": "CGT/MARTX, cysteine protease (CPD) domain", "go_ids": [], "go_terms": [], "name": "CPD_dom", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR020975": {"description": "UvsW.1 domain", "go_ids": [], "go_terms": [], "name": "UvsW.1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020976": {"description": "LCI fold", "go_ids": [], "go_terms": [], "name": "Antimicrobial_lci", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020977": {"description": "Beta-casein-like", "go_ids": [], "go_terms": [], "name": "Beta-casein-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020978": {"description": "Cryptochrome C-terminal", "go_ids": [], "go_terms": [], "name": "Cryptochrome_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020979": {"description": "Uncharacterised protein family A0KLC6", "go_ids": [], "go_terms": [], "name": "Uncharacterised_A0KLC6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020980": {"description": "Menbrane protein HflK, N-terminal", "go_ids": [], "go_terms": [], "name": "Membrane_HflK_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020981": {"description": "Monopolin complex subunit Csm1/Pcs1, C-terminal", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "-Csm1/Pcs1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020982": {"description": "Bacteriophage T4, GpT, holin", "go_ids": ["GO:0044659"], "go_terms": ["GO:0044659:viral release from host cell by cytolysis:P"], "name": "Phage_T4_GpT_holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020983": {"description": "Basic leucine-zipper, C-terminal", "go_ids": [], "go_terms": [], "name": "Basic_leucine-zipper_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020984": {"description": "Speedy", "go_ids": ["GO:0019901", "GO:0045737"], "go_terms": ["GO:0019901:protein kinase binding:F", "GO:0045737:positive regulation of cyclin-dependent protein serine/threonine kinase activity:P"], "name": "Speedy", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020985": {"description": "Cell surface protein Shp, haem-binding domain", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "Cell_surface_Shp_haem-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020986": {"description": "Chemotaxis inhibitory protein", "go_ids": [], "go_terms": [], "name": "CHIPS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020987": {"description": "Centromere protein Cenp-M", "go_ids": [], "go_terms": [], "name": "Centromere_Cenp-M", "pathway_ids": ["R-MMU-2500257", "R-HSA-606279", "R-HSA-2500257", "R-MMU-141444", "R-HSA-2467813", "R-DRE-2500257", "R-MMU-2467813", "R-MMU-9648025", "R-MMU-606279", "R-HSA-141444", "R-BTA-5663220", "R-DRE-2467813", "R-DRE-141444", "R-BTA-606279", "R-MMU-68877", "R-HSA-9648025", "R-BTA-2467813", "R-HSA-68877", "R-BTA-2500257", "R-HSA-5663220", "R-DRE-5663220", "R-BTA-9648025", "R-BTA-141444", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR020988": {"description": "Peptidase U32, collagenase", "go_ids": [], "go_terms": [], "name": "Pept_U32_collagenase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020990": {"description": "Carboxysome assembly protein CsoS2/2B", "go_ids": ["GO:0043886"], "go_terms": ["GO:0043886:structural constituent of carboxysome shell:F"], "name": "CSOS2/2B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020991": {"description": "Head-to-tail connector protein, podovirus-type", "go_ids": [], "go_terms": [], "name": "Connector_podovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020992": {"description": "Tail specific protease, C-terminal", "go_ids": [], "go_terms": [], "name": "Tail_Prtase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020993": {"description": "Centromere protein Cenp-K", "go_ids": ["GO:0005634", "GO:0051382"], "go_terms": ["GO:0005634:nucleus:C", "GO:0051382:kinetochore assembly:P"], "name": "Centromere_CenpK", "pathway_ids": ["R-MMU-2500257", "R-HSA-606279", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-2467813", "R-HSA-141444", "R-MMU-606279", "R-HSA-9648025", "R-MMU-68877", "R-GGA-2500257", "R-GGA-141444", "R-HSA-68877", "R-GGA-9648025", "R-GGA-606279", "R-GGA-5663220", "R-HSA-5663220", "R-GGA-2467813", "R-MMU-9648025", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR020994": {"description": "Uncharacterised protein family, calcium binding protein, CcbP", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ca-bd_CcbP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020995": {"description": "Chlorosome envelope protein C", "go_ids": [], "go_terms": [], "name": "Chlorosome_envelope_CsmC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020996": {"description": "Type III secretion system, AvrPto", "go_ids": [], "go_terms": [], "name": "T3SS_AvrPto", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020997": {"description": "Ataxin-1, N-terminal", "go_ids": [], "go_terms": [], "name": "Ataxin-1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR020998": {"description": "Mediator of RNA polymerase II transcription subunit 3", "go_ids": ["GO:0003712", "GO:0006357", "GO:0016592"], "go_terms": ["GO:0003712:transcription coregulator activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0016592:mediator complex:C"], "name": "Med3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR020999": {"description": "RCR1/2", "go_ids": [], "go_terms": [], "name": "RCR1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021001": {"description": "Spidroin, C-terminal", "go_ids": [], "go_terms": [], "name": "Spidroin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021002": {"description": "Replication protein 1a, necrotic phentoype-determining domain", "go_ids": ["GO:0016817", "GO:0008168"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F", "GO:0008168:methyltransferase activity:F"], "name": "1a_necrotic_phenotyp-det_dom", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7250", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR021003": {"description": "Cytomegalovirus glycoprotein N, N-terminal", "go_ids": [], "go_terms": [], "name": "Cytomegalovirus_glycopN_N", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Domain"}, "IPR021004": {"description": "Dispersed gene family protein 1, domain 4", "go_ids": [], "go_terms": [], "name": "Dispersed_gene_fam_prot1_dom4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021005": {"description": "Zinc finger, CGNR", "go_ids": [], "go_terms": [], "name": "Znf_CGNR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021006": {"description": "HDA1 complex subunit 2/3", "go_ids": ["GO:0070823"], "go_terms": ["GO:0070823:HDA1 complex:C"], "name": "Hda2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021007": {"description": "Complementary sex determiner, C-terminal", "go_ids": [], "go_terms": [], "name": "Sex_determ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021008": {"description": "D-Ala-teichoic acid biosynthesis protein DltX", "go_ids": [], "go_terms": [], "name": "DltX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021009": {"description": "Motility repressor MogR, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "MogR_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021010": {"description": "Cytosolic motility protein", "go_ids": [], "go_terms": [], "name": "Cytosolic_motility_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021011": {"description": "DNA replication regulator, HobA", "go_ids": [], "go_terms": [], "name": "HobA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021012": {"description": "Cell adhesion molecule Dscam1, C-terminal", "go_ids": [], "go_terms": [], "name": "Dscam1_C", "pathway_ids": ["R-DME-376172"], "pathways": ["R-DME-376172:r:DSCAM interactions"], "type": "Domain"}, "IPR021013": {"description": "ATPase, vacuolar ER assembly factor, Vma12", "go_ids": ["GO:0070072"], "go_terms": ["GO:0070072:vacuolar proton-transporting V-type ATPase complex assembly:P"], "name": "ATPase_Vma12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021014": {"description": "SidE, PDE domain", "go_ids": [], "go_terms": [], "name": "SidE_PDE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021015": {"description": "Duffy-antigen binding, C-terminal", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Duffy-antigen-binding_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021016": {"description": "Beta-1,3-xylanase", "go_ids": ["GO:0033905"], "go_terms": ["GO:0033905:xylan endo-1,3-beta-xylosidase activity:F"], "name": "Beta-xylanase", "pathway_ids": ["PWY-6789"], "pathways": ["PWY-6789:t:(1,3)-beta-D-xylan degradation"], "type": "Family"}, "IPR021017": {"description": "Mediator complex, subunit Med2, fungi", "go_ids": [], "go_terms": [], "name": "Mediator_Med2_fun", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021018": {"description": "Mediator complex, subunit Med29, metazoa", "go_ids": ["GO:0016592"], "go_terms": ["GO:0016592:mediator complex:C"], "name": "Mediator_Med29_met", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR021019": {"description": "Mediator complex, subunit Med30, metazoa", "go_ids": [], "go_terms": [], "name": "Mediator_Med30_met", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-BTA-9841922", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR021020": {"description": "Adhesin, Dr family, signal peptide", "go_ids": [], "go_terms": [], "name": "Adhesin_Dr_signal_peptide", "pathway_ids": [], "pathways": [], "type": "PTM"}, "IPR021021": {"description": "Fibronectin-binding repeat, SSURE", "go_ids": [], "go_terms": [], "name": "Fibronectin-binding_SSURE", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR021022": {"description": "Human herpes virus-8, Protein K1, cytoplasmic domain", "go_ids": [], "go_terms": [], "name": "HHSV-8_K1_cytoplasmic_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021023": {"description": "Envelope glycoprotein UL132", "go_ids": [], "go_terms": [], "name": "UL132", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR021025": {"description": "Fanconi Anaemia group E protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Fanconi_anaemia_gr_E_prot_C", "pathway_ids": ["R-HSA-9833482", "R-HSA-6783310"], "pathways": ["R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR021026": {"description": "Filamentous haemagglutinin family outer membrane protein, domain of unknown function DUF3739", "go_ids": [], "go_terms": [], "name": "Filamn_hemagglutn_DUF3739", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021027": {"description": "Transposase, putative, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "Transposase_put_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021028": {"description": "Homotrimeric ring hydroxylase, catalytic domain", "go_ids": [], "go_terms": [], "name": "Homotrim_ring_OHase_catalytic", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021029": {"description": "DNA polymerase III, tau subunit, domain V", "go_ids": ["GO:0003887"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F"], "name": "DNA_pol_III_tau_dom-5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021030": {"description": "Protein of unknown function DUF3731", "go_ids": [], "go_terms": [], "name": "DUF3731", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021031": {"description": "Hyphally-regulated cell wall protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Hyphal-reg_cell_wall_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021032": {"description": "Duffy-antigen binding, N-terminal", "go_ids": [], "go_terms": [], "name": "Duffy-antigen-binding_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021033": {"description": "Extracellular fibrinogen binding protein, C-terminal", "go_ids": ["GO:0005576", "GO:0001848"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0001848:complement binding:F"], "name": "Extracellular_fibrinogen-bd_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021034": {"description": "Tip attachment protein J, C-terminal receptor binding domain", "go_ids": [], "go_terms": [], "name": "GpJ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021035": {"description": "Glycoprotein 60, Cryptosporidium spp", "go_ids": [], "go_terms": [], "name": "Glycop-60_Cryptosporidium", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021036": {"description": "Small ribosomal subunit protein mS45", "go_ids": [], "go_terms": [], "name": "Ribosomal_mS45", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021037": {"description": "Stomoxyn", "go_ids": ["GO:0042742", "GO:0050832"], "go_terms": ["GO:0042742:defense response to bacterium:P", "GO:0050832:defense response to fungus:P"], "name": "Stomoxyn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021038": {"description": "Herpesvirus UL130, cytomegalovirus", "go_ids": [], "go_terms": [], "name": "Herpes_UL130_cytomegalovirus", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR021039": {"description": "Iron-sulphur binding protein LdpA, C-terminal", "go_ids": [], "go_terms": [], "name": "Fe-S-bd_prot_LdpA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021040": {"description": "LRRC8, pannexin-like TM region", "go_ids": [], "go_terms": 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"R-SSC-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-9833482:r:PKR-mediated signaling", "R-SSC-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DRE-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-DRE-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SSC-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5602636:r:IKBKB deficiency causes SCID", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-4755510:r:SUMOylation of immune response proteins", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-SSC-5689880:r:Ub-specific processing proteases", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-RNO-4755510:r:SUMOylation of immune response proteins", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5603027:r:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Domain"}, "IPR021064": {"description": "Estrogen receptor beta-like, N-terminal", "go_ids": [], "go_terms": [], "name": "ER-beta-like_N", "pathway_ids": ["R-MMU-8939211", "R-BTA-8939211", "R-MMU-6811558", "R-RNO-1257604", "R-RNO-9009391", "R-MMU-9009391", "R-MMU-1257604", "R-HSA-2219530", "R-BTA-9009391", "R-HSA-6811558", "R-HSA-9009391", "R-MMU-383280", "R-HSA-383280", "R-BTA-383280", "R-RNO-6811558", "R-HSA-8939211", "R-BTA-6811558", "R-BTA-1257604", "R-HSA-1257604", "R-RNO-8939211", "R-RNO-383280"], "pathways": ["R-MMU-8939211:r:ESR-mediated signaling", "R-BTA-8939211:r:ESR-mediated signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-BTA-383280:r:Nuclear Receptor transcription pathway", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8939211:r:ESR-mediated signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-8939211:r:ESR-mediated signaling", "R-RNO-383280:r:Nuclear Receptor transcription pathway"], "type": "Domain"}, "IPR021065": {"description": "Fertility inhibition protein FinO, N-terminal", "go_ids": [], "go_terms": [], "name": "Fertility_inhibition_FinO_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021066": {"description": "Fungal protease inhibitor-1", "go_ids": ["GO:0030414", "GO:0010466"], "go_terms": ["GO:0030414:peptidase inhibitor activity:F", "GO:0010466:negative regulation of peptidase activity:P"], "name": "FPI1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021067": {"description": "Glycosyltransferase, GlcNAc", "go_ids": [], "go_terms": [], "name": "Glycosyltransferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021068": {"description": "HTH DNA binding domain", "go_ids": [], "go_terms": [], "name": "HTH_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021069": {"description": "ImpA, C-terminal", "go_ids": [], "go_terms": [], "name": "ImpA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021070": {"description": "Killing trait, RebB", "go_ids": [], "go_terms": [], "name": "Killing_trait_RebB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021071": {"description": "Low molecular weight S layer protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Low_molc_weight_S-layer_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021072": {"description": "Melanoma associated antigen, N-terminal", "go_ids": [], "go_terms": [], "name": "MAGE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021073": {"description": "MHC class I-like protein M157, MHC-like domain", "go_ids": [], "go_terms": [], "name": "MHC_M157", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021074": {"description": "Formate dehydrogenase, delta subunit", "go_ids": [], "go_terms": [], "name": "Formate_DH_dsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021075": {"description": "Bocavirus non-capsid protein, NP1", "go_ids": [], "go_terms": [], "name": "Bocavirus_NP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021076": {"description": "Parvovirus non-structural protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "Parvovirus_NS1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021077": {"description": "Bacteriophage phi-Lf, Orf112", "go_ids": [], "go_terms": [], "name": "Phage_phi-Lf_Orf112", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021078": {"description": "Membrane-integrating protein Mistic", "go_ids": [], "go_terms": [], "name": "Membrane-integrating_Mistic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021079": {"description": "Methanol-cobalamin methyltransferase, B subunit", "go_ids": [], "go_terms": [], "name": "MeOH-cob_MeTrfase_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021080": {"description": "Minor capsid protein", "go_ids": [], "go_terms": [], "name": "Minor_capsid_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021081": {"description": "Nepovirus subgroup A, RNA2 polyprotein, Protein 2A", "go_ids": [], "go_terms": [], "name": "Nepovirus_subgr_A_2A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021082": {"description": "Protein GAPT", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Protein_GAPT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021083": {"description": "Nuclear abundant poly(A) RNA-binding protein Nab2, N-terminal", "go_ids": [], "go_terms": [], "name": "Nab2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021084": {"description": "Het-s prion-forming domain", "go_ids": [], "go_terms": [], "name": "Het-s_prion_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021085": {"description": "AvrE-family Type-III effector protein", "go_ids": [], "go_terms": [], "name": "AvrE_T3Es", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021086": {"description": "Accessory protein p12I", "go_ids": [], "go_terms": [], "name": "p12I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021087": {"description": "Uncharacterised protein family PixA/AidA", "go_ids": [], "go_terms": [], "name": "Uncharacterised_PixA/AidA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021088": {"description": "Osteocrin", "go_ids": [], "go_terms": [], "name": "Osteocrin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021089": {"description": "Bacteriocin, lactococcin-G", "go_ids": [], "go_terms": [], "name": "Bacteriocin_lactococcin-G", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021090": {"description": "SLy proteins associated disordered region", "go_ids": [], "go_terms": [], "name": "SPIDER", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021091": {"description": "Mercury ion transport, MerF", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Mercury_ion_transport_MerF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021093": {"description": "NADH-quinone oxidoreductase, subunit15", "go_ids": [], "go_terms": [], "name": "NADH_quinone_OxRdtase_su15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021094": {"description": "NPR1/NIM1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "NPR1/NIM1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021095": {"description": "Domain of unknown function DUF3734", "go_ids": [], "go_terms": [], "name": "DUF3734", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021096": {"description": "Vibrio phage VSK, Orf152", "go_ids": [], "go_terms": [], "name": "Vibrio_phage_VSK_Orf152", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021097": {"description": "CPH domain", "go_ids": [], "go_terms": [], "name": "CPH_domain", "pathway_ids": ["R-MMU-69473", "R-DME-983168", "R-HSA-5693571", "R-HSA-381038", "R-HSA-5693607", "R-HSA-3108214", "R-RNO-8951664", "R-HSA-69473", "R-HSA-8951664", "R-MMU-983168", "R-MMU-3108214", "R-HSA-5693565", "R-HSA-983168", "R-RNO-983168", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-8951664:r:Neddylation", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR021098": {"description": "Bacteriophage P22, Gp10, DNA-stabilising", "go_ids": [], "go_terms": [], "name": "Phage_P22_Gp10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021099": {"description": "Plant organelle RNA recognition domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "PORR_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021100": {"description": "N-glycosylation protein EOS1", "go_ids": ["GO:0034599", "GO:0005789"], "go_terms": ["GO:0034599:cellular response to oxidative stress:P", "GO:0005789:endoplasmic reticulum membrane:C"], "name": "N-glycosylation_EOS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021101": {"description": "Optomotor-blind protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Optomoror-blind_N", "pathway_ids": ["R-DME-9856649"], "pathways": ["R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Domain"}, "IPR021102": {"description": "Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A", "go_ids": [], "go_terms": [], "name": "PNGase_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021103": {"description": "Argonaute PAZ domain, archaea", "go_ids": [], "go_terms": [], "name": "PAZ_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021104": {"description": "KfrA, N-terminal DNA-binding domain", "go_ids": [], "go_terms": [], "name": "KfrA_DNA-bd_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021106": {"description": "Protein Ste5, Fus3-binding domain", "go_ids": [], "go_terms": [], "name": "Ste5_Fus3-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021107": {"description": "Restriction endonuclease, type II, HinP1I", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_HinP1I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021108": {"description": "Restriction endonuclease, type II, BpuJI, N-terminal", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_BpuJI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021109": {"description": "Aspartic peptidase domain superfamily", "go_ids": [], "go_terms": [], "name": "Peptidase_aspartic_dom_sf", "pathway_ids": ["R-SPO-2132295", "R-HSA-6798695", "R-HSA-180910", "R-SPO-6798695", "R-HSA-2132295", "R-GGA-2022377", "R-HSA-77387", "R-HSA-977225", "R-CEL-6798695", "R-SCE-6798695", "R-CFA-77387", "R-CFA-1442490", "R-CEL-2132295", "R-HSA-164525", "R-CFA-2022377", "R-HSA-162592", "R-CFA-5683826", "R-PFA-2132295", "R-MMU-2132295", "R-CFA-2132295", "R-HSA-175474", "R-HSA-9018519", "R-HSA-1442490", "R-MMU-5683826", "R-MMU-2022377", "R-HSA-173107", "R-DDI-6798695", "R-DDI-5683826", "R-MMU-77387", "R-RNO-2132295", "R-HSA-164516", "R-RNO-2022377", "R-HSA-162585", "R-GGA-77387", "R-GGA-1442490", "R-HSA-2022377", "R-CEL-5683826", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-RNO-1442490", "R-HSA-162594", "R-RNO-77387", "R-GGA-6798695", "R-GGA-2132295", "R-HSA-5683826", "R-HSA-177539", "R-PFA-6798695", "R-SCE-2132295", "R-MMU-6798695", "R-HSA-175567", "R-CEL-1442490", "R-CFA-6798695", "R-SSC-5683826", "R-MMU-1442490", "R-RNO-6798695", "R-DDI-2132295"], "pathways": ["R-SPO-2132295:r:MHC class II antigen presentation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-GGA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-977225:r:Amyloid fiber formation", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-CFA-77387:r:Insulin receptor recycling", "R-CFA-1442490:r:Collagen degradation", "R-CEL-2132295:r:MHC class II antigen presentation", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-CFA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-162592:r:Integration of provirus", "R-CFA-5683826:r:Surfactant metabolism", "R-PFA-2132295:r:MHC class II antigen presentation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-CFA-2132295:r:MHC class II antigen presentation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-1442490:r:Collagen degradation", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-173107:r:Binding and entry of HIV virion", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-5683826:r:Surfactant metabolism", "R-MMU-77387:r:Insulin receptor recycling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-GGA-77387:r:Insulin receptor recycling", "R-GGA-1442490:r:Collagen degradation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CEL-5683826:r:Surfactant metabolism", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-RNO-1442490:r:Collagen degradation", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-RNO-77387:r:Insulin receptor recycling", "R-GGA-6798695:r:Neutrophil degranulation", "R-GGA-2132295:r:MHC class II antigen presentation", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-PFA-6798695:r:Neutrophil degranulation", "R-SCE-2132295:r:MHC class II antigen presentation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-CEL-1442490:r:Collagen degradation", "R-CFA-6798695:r:Neutrophil degranulation", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-1442490:r:Collagen degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-2132295:r:MHC class II antigen presentation"], "type": "Homologous_superfamily"}, "IPR021110": {"description": "DNA replication/checkpoint protein", "go_ids": ["GO:0006260"], "go_terms": ["GO:0006260:DNA replication:P"], "name": "DNA_rep_checkpnt_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021111": {"description": "Hexameric tyrosine-coordinated heme protein (HTHP)", "go_ids": [], "go_terms": [], "name": "Hexamer_Tyr-coord_heme_pr_HTHP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021112": {"description": "Group II intron-interrupted relaxase LtrB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LtrB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021113": {"description": "Acyl-ACP-thioesterase, N-terminal", "go_ids": ["GO:0016790"], "go_terms": ["GO:0016790:thiolester hydrolase activity:F"], "name": "Acyl-ACP-thioesterase_N", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis"], "type": "Domain"}, "IPR021114": {"description": "Porin PorB/PorC", "go_ids": [], "go_terms": [], "name": "Porin_PorB/PorC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021116": {"description": "Calcitonin/adrenomedullin", "go_ids": ["GO:0005576", "GO:0005179"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0005179:hormone activity:F"], "name": "Calcitonin/adrenomedullin", "pathway_ids": ["R-MMU-9856530", "R-CFA-419812", "R-HSA-977225", "R-HSA-418555", "R-HSA-210745", "R-SSC-419812", "R-HSA-419812", "R-RNO-9856530", "R-MMU-419812", "R-SSC-9856530", "R-BTA-418555", "R-BTA-419812", "R-HSA-9856530", "R-RNO-419812", "R-BTA-9856530", "R-MMU-418555"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", 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"R-MMU-418555:r:G alpha (s) signalling events"], "type": "Family"}, "IPR021117": {"description": "Calcitonin-like", "go_ids": ["GO:0005576", "GO:0005179"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0005179:hormone activity:F"], "name": "Calcitonin-like", "pathway_ids": ["R-MMU-419812", "R-CFA-419812", "R-HSA-977225", "R-HSA-418555", "R-HSA-210745", "R-RNO-419812", "R-MMU-418555", "R-HSA-419812"], "pathways": ["R-MMU-419812:r:Calcitonin-like ligand receptors", "R-CFA-419812:r:Calcitonin-like ligand receptors", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-RNO-419812:r:Calcitonin-like ligand receptors", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-419812:r:Calcitonin-like ligand receptors"], "type": "Family"}, "IPR021119": {"description": "Poxvirus F1/C10", "go_ids": ["GO:0033668"], "go_terms": ["GO:0033668:symbiont-mediated suppression of host apoptosis:P"], "name": "Poxvirus_F1/C10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021120": {"description": "KduI/IolB isomerase", "go_ids": ["GO:0016861"], "go_terms": ["GO:0016861:intramolecular oxidoreductase activity, interconverting aldoses and ketoses:F"], "name": "KduI/IolB_isomerase", "pathway_ids": ["PWY-6507"], "pathways": ["PWY-6507:t:4-deoxy-L-threo-hex-4-enopyranuronate degradation"], "type": "Family"}, "IPR021122": {"description": "RNA ligase domain, REL/Rln2", "go_ids": [], "go_terms": [], "name": "RNA_ligase_dom_REL/Rnl2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021123": {"description": "Type III secretion, needle-protein-like", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "T3SS_needle-like", "pathway_ids": ["R-HSA-844623"], "pathways": ["R-HSA-844623:r:The IPAF inflammasome"], "type": "Family"}, "IPR021124": {"description": "CRISPR-associated protein, Cas5", "go_ids": ["GO:0043571"], "go_terms": 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"R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-9629569:r:Protein hydroxylation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CFA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP 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"go_ids": [], "go_terms": [], "name": "DUF697", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021148": {"description": "Polysaccharide biosynthesis domain", "go_ids": [], "go_terms": [], "name": "Polysacc_synth_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021149": {"description": "MAGT1/OST3/OST6", "go_ids": [], "go_terms": [], "name": "MAGT1/OST3/OST6", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-BTA-9931295", "R-DRE-9768727", "R-HSA-9694548", "R-SPO-5223345", "R-CEL-6798695", "R-XTR-9768727", "R-SCE-6798695", "R-RNO-5223345", "R-MMU-9931295", "R-CFA-9768727", "R-DRE-6798695", "R-RNO-9768727", "R-HSA-5223345", "R-HSA-9931295", "R-DDI-6798695", "R-HSA-446203", "R-MMU-5223345", "R-HSA-9918432", "R-DDI-5223345", "R-CFA-9931295", "R-DRE-5223345", "R-RNO-9931295", "R-CEL-5223345", "R-BTA-9768727", "R-SCE-5223345", "R-MMU-6798695", "R-HSA-9768727", "R-MMU-9768727", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", 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"R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DDI-5223345:r:Miscellaneous transport and binding events", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DRE-5223345:r:Miscellaneous transport and binding events", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CEL-5223345:r:Miscellaneous transport and binding events", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SCE-5223345:r:Miscellaneous transport and binding events", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR021150": {"description": "Ubiquinol-cytochrome c chaperone", "go_ids": [], "go_terms": [], "name": "Ubiq_cyt_c_chap", "pathway_ids": ["R-SCE-9865878", "R-HSA-9865881"], "pathways": ["R-SCE-9865878:r:Complex III assembly", "R-HSA-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR021151": {"description": "GINS subunit, domain A", "go_ids": [], "go_terms": [], "name": "GINS_A", "pathway_ids": ["R-BTA-176974", "R-DME-176974", "R-HSA-176974", "R-CEL-176974", "R-RNO-176974", "R-SPO-176974", "R-DDI-176974", "R-MMU-176974", "R-SCE-176974"], "pathways": ["R-BTA-176974:r:Unwinding of DNA", "R-DME-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-CEL-176974:r:Unwinding of DNA", "R-RNO-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA"], "type": "Domain"}, "IPR021152": {"description": "Herpesvirus UL31", "go_ids": ["GO:0046765", "GO:0046802"], "go_terms": ["GO:0046765:viral budding from nuclear membrane:P", "GO:0046802:exit of virus from host cell nucleus by nuclear egress:P"], "name": "Herpes_UL31", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR021153": {"description": "Heat-inducible transcription repressor HrcA, C-terminal", "go_ids": ["GO:0006355", "GO:0003677"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F"], "name": "HrcA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021155": {"description": "Poxvirus E2/O1", "go_ids": [], "go_terms": [], "name": "Poxvirus_E2/O1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021156": {"description": "Transcription elongation factor A-like/Brain expressed X-linked", "go_ids": [], "go_terms": [], "name": "TF_A-like/BEX", "pathway_ids": ["R-HSA-205025", "R-MMU-205025", "R-RNO-205025", "R-BTA-205025"], "pathways": ["R-HSA-205025:r:NADE modulates death signalling", "R-MMU-205025:r:NADE modulates death signalling", "R-RNO-205025:r:NADE modulates death signalling", "R-BTA-205025:r:NADE modulates death signalling"], "type": "Family"}, "IPR021157": {"description": "Cytochrome c1, transmembrane anchor, C-terminal", "go_ids": [], "go_terms": [], "name": "Cyt_c1_TM_anchor_C", "pathway_ids": ["PWY-7279", "PWY-6692", "PWY-3781", "R-SCE-9865878", "R-HSA-611105", "R-HSA-9865881", "R-DDI-611105", "R-HSA-1268020", "R-MMU-611105", "R-SPO-611105", "R-BTA-9865881", "R-SCE-611105", "R-BTA-611105", "R-MMU-9865881"], "pathways": ["PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "PWY-6692:t:Fe(II) oxidation", "PWY-3781:t:aerobic respiration I (cytochrome c)", "R-SCE-9865878:r:Complex III assembly", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-9865881:r:Complex III assembly", "R-DDI-611105:r:Respiratory electron transport", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-BTA-9865881:r:Complex III assembly", "R-SCE-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR021160": {"description": "Mitogen-activated protein (MAP) kinase kinase kinase kinase", "go_ids": ["GO:0005524", "GO:0008349"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0008349:MAP kinase kinase kinase kinase activity:F"], "name": "MAPKKKK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021162": {"description": "Histone H3-K79 methyltransferase, fungi", "go_ids": ["GO:0031509", "GO:0042393", "GO:0000786", "GO:0000077", "GO:0006281", "GO:0031151"], "go_terms": ["GO:0031509:subtelomeric heterochromatin formation:P", "GO:0042393:histone binding:F", "GO:0000786:nucleosome:C", "GO:0000077:DNA damage checkpoint signaling:P", "GO:0006281:DNA repair:P", "GO:0031151:histone H3K79 methyltransferase activity:F"], "name": "Dot1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021163": {"description": "Ferredoxin-NADP+ reductase, adrenodoxin-type", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Ferredox_Rdtase_adrenod", "pathway_ids": ["R-MMU-196108", "R-HSA-196108", "R-RNO-2395516", "R-DDI-2395516", "R-SCE-2395516", "R-MMU-211976", "R-RNO-211976", "R-HSA-2395516", "R-HSA-5579026", "R-MMU-2395516", "R-SPO-2395516", "R-HSA-211976", "R-RNO-196108", "R-DME-2395516"], "pathways": ["R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-RNO-2395516:r:Electron transport from NADPH to Ferredoxin", "R-DDI-2395516:r:Electron transport from NADPH to Ferredoxin", "R-SCE-2395516:r:Electron transport from NADPH to Ferredoxin", "R-MMU-211976:r:Endogenous sterols", "R-RNO-211976:r:Endogenous sterols", "R-HSA-2395516:r:Electron transport from NADPH to Ferredoxin", "R-HSA-5579026:r:Defective CYP11A1 causes AICSR", "R-MMU-2395516:r:Electron transport from NADPH to Ferredoxin", "R-SPO-2395516:r:Electron transport from NADPH to Ferredoxin", "R-HSA-211976:r:Endogenous sterols", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-DME-2395516:r:Electron transport from NADPH to Ferredoxin"], "type": "Family"}, "IPR021164": {"description": "Tyrosine hydroxylase, conserved site", "go_ids": ["GO:0004511"], "go_terms": ["GO:0004511:tyrosine 3-monooxygenase activity:F"], "name": "Tyrosine_hydroxylase_CS", "pathway_ids": ["PWY-5049", "PWY-3581", "PWY-5394", "PWY-6133", "R-RNO-209905", "R-HSA-209905", "R-MMU-209905"], "pathways": ["PWY-5049:t:rosmarinic acid biosynthesis II", "PWY-3581:t:(S)-reticuline biosynthesis I", "PWY-5394:t:betalamic acid biosynthesis", "PWY-6133:t:(S)-reticuline biosynthesis II", "R-RNO-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-MMU-209905:r:Catecholamine biosynthesis"], "type": "Conserved_site"}, "IPR021165": {"description": "Saposin, chordata", "go_ids": ["GO:0006665", "GO:0005764"], "go_terms": ["GO:0006665:sphingolipid metabolic process:P", "GO:0005764:lysosome:C"], "name": "Saposin_chordata", "pathway_ids": ["R-HSA-6798695", "R-HSA-114608", "R-RNO-9840310", "R-HSA-418594", "R-MMU-9840310", "R-MMU-114608", "R-RNO-375276", "R-HSA-375276", "R-HSA-9840310", "R-MMU-6798695", "R-MMU-375276", "R-MMU-418594", "R-RNO-6798695", "R-RNO-114608", "R-RNO-418594"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-MMU-114608:r:Platelet degranulation", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR021167": {"description": "Uncharacterised conserved protein, UCP027887, phosphatidlglycerophosphatase-related", "go_ids": [], "go_terms": [], "name": "UCP027887_Ptd-glyceroPase-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021168": {"description": "Bifunctional polymyxin resistance protein, ArnA", "go_ids": ["GO:0016742"], "go_terms": ["GO:0016742:hydroxymethyl-, formyl- and related transferase activity:F"], "name": "Bifun_polymyxin_resist_ArnA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021169": {"description": "Histone H3-K79 methyltransferase, metazoa", "go_ids": ["GO:0005634", "GO:0031507", "GO:0031151"], "go_terms": ["GO:0005634:nucleus:C", "GO:0031507:heterochromatin formation:P", "GO:0031151:histone H3K79 methyltransferase activity:F"], "name": "DOT1L/grappa", "pathway_ids": ["R-MMU-3214841", "R-HSA-3214841"], "pathways": ["R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines"], "type": "Family"}, "IPR021170": {"description": "DnaJ homologue subfamily C member 10", "go_ids": ["GO:0005783", "GO:0034975", "GO:0015036"], "go_terms": ["GO:0005783:endoplasmic reticulum:C", "GO:0034975:protein folding in endoplasmic reticulum:P", "GO:0015036:disulfide oxidoreductase activity:F"], "name": "ERdj5", "pathway_ids": ["R-HSA-9918432"], "pathways": ["R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Family"}, "IPR021171": {"description": "Core histone macro-H2A", "go_ids": ["GO:0000786", "GO:0006334", "GO:0003677", "GO:0030527"], "go_terms": ["GO:0000786:nucleosome:C", "GO:0006334:nucleosome assembly:P", "GO:0003677:DNA binding:F", "GO:0030527:structural constituent of chromatin:F"], "name": "Core_histone_macro-H2A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021172": {"description": "Uncharacterised conserved protein, RNA methylase-related", "go_ids": [], "go_terms": [], "name": "UCP006607_RNA_methylase-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021173": {"description": "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase", "go_ids": [], "go_terms": [], "name": "Algn-8", "pathway_ids": ["R-CEL-446193"], "pathways": ["R-CEL-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Family"}, "IPR021174": {"description": "Uncharacterised conserved protein UCP037139", "go_ids": [], "go_terms": [], "name": "UCP037139", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021175": {"description": "Bifunctional inorganic polyphosphate/ATP-NAD kinase, predicted", "go_ids": [], "go_terms": [], "name": "Bifunctional_PpnK_predicted", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021176": {"description": "Competence-induced protein CoiA", "go_ids": [], "go_terms": [], "name": "Competence-induced_CoiA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021177": {"description": "Serum albumin/Alpha-fetoprotein/Afamin", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Serum_albumin/AFP/Afamin", "pathway_ids": ["R-RNO-189451", "R-HSA-9757110", "R-HSA-2168880", "R-MMU-8957275", "R-HSA-189483", "R-RNO-114608", "R-RNO-9757110", "R-BTA-8957275", "R-HSA-114608", "R-MMU-189483", "R-RNO-9793528", "R-RNO-159418", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-9707564", "R-MMU-9749641", "R-RNO-189483", "R-MMU-8964058", "R-RNO-8964058", "R-HSA-381426", "R-MMU-2168880", "R-SSC-381426", "R-SSC-8957275", "R-MMU-189451", "R-HSA-8964058", "R-MMU-9757110", "R-RNO-2168880", "R-RNO-9707564", "R-MMU-9793528", "R-HSA-189451", "R-RNO-381426", "R-HSA-9749641", "R-HSA-9793528", "R-RNO-9749641", "R-HSA-8957275", "R-HSA-159418", "R-MMU-159418", "R-MMU-9707564", "R-MMU-114608"], "pathways": ["R-RNO-189451:r:Heme biosynthesis", "R-HSA-9757110:r:Prednisone ADME", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-189483:r:Heme degradation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-9757110:r:Prednisone ADME", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-MMU-189483:r:Heme degradation", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-189483:r:Heme degradation", "R-MMU-8964058:r:HDL remodeling", "R-RNO-8964058:r:HDL remodeling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-189451:r:Heme biosynthesis", "R-HSA-8964058:r:HDL remodeling", "R-MMU-9757110:r:Prednisone ADME", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-HSA-189451:r:Heme biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-RNO-9749641:r:Aspirin ADME", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-159418:r:Recycling of bile acids and salts", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR021179": {"description": "Mercury(II) reductase", "go_ids": ["GO:0050787", "GO:0050661", "GO:0045340", "GO:0016152", "GO:0016491", "GO:0050660"], "go_terms": ["GO:0050787:detoxification of mercury ion:P", "GO:0050661:NADP binding:F", "GO:0045340:mercury ion binding:F", "GO:0016152:mercury (II) reductase (NADP+) activity:F", "GO:0016491:oxidoreductase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "Mercury_reductase_MerA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021180": {"description": "Protein lysine methyltranseferase, predicted", "go_ids": [], "go_terms": [], "name": "Protein_Lys_MeTrfase_predicted", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021181": {"description": "Mitochondrial Rho GTPase", "go_ids": ["GO:0005741", "GO:0003924", "GO:0005525", "GO:0005509", "GO:0007005"], "go_terms": ["GO:0005741:mitochondrial outer membrane:C", "GO:0003924:GTPase activity:F", "GO:0005525:GTP binding:F", "GO:0005509:calcium ion binding:F", "GO:0007005:mitochondrion organization:P"], "name": "Miro", "pathway_ids": ["R-DRE-5689880", "R-BTA-9013425", "R-CEL-9013419", "R-BTA-5689880", "R-SPO-9013419", "R-HSA-5689880", "R-SPO-9013425", "R-DME-9013419", "R-RNO-9013419", "R-DME-9013425", "R-DDI-9013422", "R-HSA-9013425", "R-GGA-9013419", "R-MMU-5689880", "R-DRE-9013425", "R-SCE-9013425", "R-SCE-9013419", "R-BTA-9013419", "R-XTR-9013419", "R-MMU-9013425", "R-HSA-9013419", "R-CEL-9013425", "R-DRE-9013419", "R-DDI-9013418", "R-DME-5689880", "R-MMU-9013419"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-9013425:r:RHOT1 GTPase cycle", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-GGA-9013419:r:RHOT2 GTPase cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DRE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-BTA-9013419:r:RHOT2 GTPase cycle", "R-XTR-9013419:r:RHOT2 GTPase cycle", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-CEL-9013425:r:RHOT1 GTPase cycle", "R-DRE-9013419:r:RHOT2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-9013419:r:RHOT2 GTPase cycle"], "type": "Family"}, "IPR021182": {"description": "Protein SOSEKI, magnoliopsida", "go_ids": [], "go_terms": [], "name": "SOK_magnoliopsida", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021183": {"description": "N-terminal acetyltransferase A, auxiliary subunit", "go_ids": [], "go_terms": [], "name": "NatA_aux_su", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021185": {"description": "Tumour necrosis factor family protein, CD30 ligand type", "go_ids": [], "go_terms": [], "name": "TNF_CD30_ligand_type", "pathway_ids": ["R-HSA-5669034", "R-MMU-5669034"], "pathways": ["R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR021188": {"description": "N6 adenine-specific DNA methyltransferase, TaqI class", "go_ids": [], "go_terms": [], "name": "N6_DNA_MeTrfase_TaqI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021190": {"description": "Peptidase M10A", "go_ids": ["GO:0006508", "GO:0004222", "GO:0008270"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0004222:metalloendopeptidase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Pept_M10A", "pathway_ids": ["R-CEL-1592389", "R-HSA-6798695", "R-RNO-2022090", "R-MMU-210991", "R-MMU-3928665", "R-RNO-1474228", "R-CEL-6798695", "R-RNO-9009391", "R-BTA-6798695", "R-HSA-2179392", "R-MMU-9009391", "R-CFA-1442490", "R-SSC-1474228", "R-RNO-2179392", "R-GGA-9009391", "R-RNO-3928665", "R-DME-3928665", "R-HSA-210991", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-MMU-1433557", "R-SSC-1592389", "R-MMU-1592389", "R-BTA-1474228", "R-RNO-9839383", "R-DME-1592389", "R-HSA-6785807", "R-GGA-1442490", "R-HSA-8941332", "R-RNO-381426", "R-RNO-1433557", "R-BTA-1592389", "R-HSA-2022090", "R-CFA-1474228", "R-MMU-6798695", "R-RNO-6798695", "R-MMU-9839383", "R-MMU-2179392", "R-GGA-1474228", "R-BTA-1442490", "R-CEL-2179392", "R-CFA-2022090", "R-CEL-1474228", "R-SSC-1442490", "R-HSA-9918481", "R-GGA-1592389", "R-HSA-1442490", "R-BTA-1433557", "R-CFA-2179392", "R-CFA-1592389", "R-CEL-210991", "R-RNO-1592389", "R-DME-6798695", "R-DME-2179392", "R-CFA-9009391", "R-HSA-9839383", "R-HSA-1592389", "R-DME-2022090", "R-HSA-1433557", "R-RNO-1442490", "R-BTA-9009391", "R-CEL-3928665", "R-MMU-2022090", "R-DME-1474228", "R-HSA-9009391", "R-HSA-3928665", "R-GGA-3928665", "R-DME-1442490", "R-CEL-1442490", "R-HSA-9856530", "R-BTA-3928665", "R-MMU-1442490"], "pathways": ["R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-210991:r:Basigin interactions", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-1442490:r:Collagen degradation", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-210991:r:Basigin interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-SSC-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-1442490:r:Collagen degradation", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-BTA-1442490:r:Collagen degradation", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-SSC-1442490:r:Collagen degradation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-GGA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-CFA-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-CEL-210991:r:Basigin interactions", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-1442490:r:Collagen degradation", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1442490:r:Collagen degradation", "R-CEL-1442490:r:Collagen degradation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1442490:r:Collagen degradation"], "type": "Family"}, "IPR021191": {"description": "Restriction endonuclease, type II, DpnII", "go_ids": ["GO:0003677", "GO:0009036", "GO:0009307"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0009036:type II site-specific deoxyribonuclease activity:F", "GO:0009307:DNA restriction-modification system:P"], "name": "Restrct_endonuc_II_DpnII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021192": {"description": "Uncharacterised conserved protein UCP031578, VanZ/RDD-type", "go_ids": [], "go_terms": [], "name": "UCP031578_Vanz/RDD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021193": {"description": "BPI fold-containing family B member 1", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Bpifb1", "pathway_ids": ["R-MMU-6803157", "R-HSA-6803157", "R-RNO-6803157"], "pathways": ["R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-RNO-6803157:r:Antimicrobial peptides"], "type": "Family"}, "IPR021194": {"description": "Uncharacterised protein family, dehydrogenase DR0790 type, predicted", "go_ids": [], "go_terms": [], "name": "Uncharacterised_DHase_DR0790", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021195": {"description": "Ubiquinol cytochrome c reductase, cytochrome c1 subunit, predicted", "go_ids": [], "go_terms": [], "name": "Ubol_Cyt_c_Rdtase_Cyt_c_su_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021197": {"description": "Cross-wall-targeting lipoprotein motif", "go_ids": [], "go_terms": [], "name": "Cross-wall-target_lipo_motif", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR021198": {"description": "Pyridoxamine 5'-phosphate oxidase, plant", "go_ids": ["GO:0004733", "GO:0008615", "GO:0052856"], "go_terms": ["GO:0004733:pyridoxamine phosphate oxidase activity:F", "GO:0008615:pyridoxine biosynthetic process:P", "GO:0052856:NAD(P)HX epimerase activity:F"], "name": "Pyridox_Oxase_pln", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021199": {"description": "Cytadherence high molecular weight protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "Cytadherence_HMW-1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021200": {"description": "Conserved hypothetical integral membrane protein, lactobacillales", "go_ids": [], "go_terms": [], "name": "CHIM_prot_lactobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021201": {"description": "Leader peptide, exosporium", "go_ids": [], "go_terms": [], "name": "Leader_pep_exosporium", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021202": {"description": "Apoptosis inhibitor Rv3654c-like", "go_ids": [], "go_terms": [], "name": "Rv3654c-like", "pathway_ids": ["R-HSA-9635465"], "pathways": ["R-HSA-9635465:r:Suppression of apoptosis"], "type": "Family"}, "IPR021203": {"description": "Muellerian-inhibiting factor", "go_ids": [], "go_terms": [], "name": "Muellerian-inhibiting_factor", "pathway_ids": ["R-MMU-201451", "R-HSA-9690406", "R-HSA-201451", "R-RNO-201451"], "pathways": ["R-MMU-201451:r:Signaling by BMP", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-HSA-201451:r:Signaling by BMP", "R-RNO-201451:r:Signaling by BMP"], "type": "Family"}, "IPR021204": {"description": "Integrating conjugative element protein, PFL4711", "go_ids": [], "go_terms": [], "name": "Integr_conj_element_PFL4711", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021205": {"description": "Lantibiotic ABC transporter permease subunit, SpaE/MutE/EpiE-like", "go_ids": [], "go_terms": [], "name": "Lanti_perm_SpaE/MutE/EpiE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021206": {"description": "MprA protease C-terminal rhombosortase-interaction domain", "go_ids": [], "go_terms": [], "name": "MprA_tail", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021207": {"description": "Integrating conjugative element protein, PFL4705", "go_ids": [], "go_terms": [], "name": "Integr_conj_element_PFL4705", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021210": {"description": "Exosporium BclB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Exosporium_BclB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021211": {"description": "Sorting assembly machinery 35kDa subunit", "go_ids": [], "go_terms": [], "name": "SAM35", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021212": {"description": "Domain of unknown function DUF2760", "go_ids": [], "go_terms": [], "name": "DUF2760", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021213": {"description": "Protein of unknown function DUF2567", "go_ids": [], "go_terms": [], "name": "DUF2567", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021214": {"description": "Protein of unknown function DUF2568", "go_ids": [], "go_terms": [], "name": "DUF2568", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021215": {"description": "Protein of unknown function DUF2752", "go_ids": [], "go_terms": [], "name": "DUF2752", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021216": {"description": "Protein of unknown function DUF2722", "go_ids": [], "go_terms": [], "name": "DUF2722", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021217": {"description": "Spiroplasma phage 1-C74, Orf10", "go_ids": [], "go_terms": [], "name": "Phage_1-C74_Orf10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021218": {"description": "Protein of unknown function DUF2784", "go_ids": [], "go_terms": [], "name": "DUF2784", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021219": {"description": "Protein of unknown function DUF2703", "go_ids": [], "go_terms": [], "name": "DUF2703", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021220": {"description": "Protein of unknown function DUF2686", "go_ids": [], "go_terms": [], "name": "DUF2686", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021221": {"description": "Protein fil", "go_ids": [], "go_terms": [], "name": "Fil", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021222": {"description": "Protein of unknown function DUF2714", "go_ids": [], "go_terms": [], "name": "DUF2714", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021223": {"description": "Abortive phage resistance protein AbiGi", "go_ids": [], "go_terms": [], "name": "AbiGi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021224": {"description": "Protein of unknown function DUF2690", "go_ids": [], "go_terms": [], "name": "DUF2690", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021225": {"description": "Tlde1 domain", "go_ids": [], "go_terms": [], "name": "Tlde1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021226": {"description": "Phage gene 29 protein", "go_ids": [], "go_terms": [], "name": "Phage_gene29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021228": {"description": "BREX system ATP-binding protein BrxD", "go_ids": [], "go_terms": [], "name": "BrxD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021229": {"description": "5'-3' exonuclease gp43/p51", "go_ids": [], "go_terms": [], "name": "Gp43/p51", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021230": {"description": "Protein of unknown function DUF2810", "go_ids": [], "go_terms": [], "name": "DUF2810", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021231": {"description": "Protein of unknown function DUF2811", "go_ids": [], "go_terms": [], "name": "DUF2811", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021232": {"description": "Protein of unknown function DUF2735", "go_ids": [], "go_terms": [], "name": "DUF2735", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021233": {"description": "Protein of unknown function DUF2783", "go_ids": [], "go_terms": [], "name": "DUF2783", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021234": {"description": "Protein of unknown function DUF2827", "go_ids": [], "go_terms": [], "name": "DUF2827", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021235": {"description": "Protein of unknown function DUF2637", "go_ids": [], "go_terms": [], "name": "DUF2637", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021236": {"description": "Uncharacterised protein family YfdX", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YfdX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021237": {"description": "Leader peptide SpeFL", "go_ids": [], "go_terms": [], "name": "SpeFL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021238": {"description": "Protein of unknown function DUF2620", "go_ids": [], "go_terms": [], "name": "DUF2620", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021239": {"description": "Protein of unknown function DUF2625", "go_ids": [], "go_terms": [], "name": "DUF2625", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021240": {"description": "Protein of unknown function DUF2776", "go_ids": [], "go_terms": [], "name": "DUF2776", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021241": {"description": "Peptidoglycan-binding protein, CsiV", "go_ids": [], "go_terms": [], "name": "CsiV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021242": {"description": "Protein of unknown function DUF2799", "go_ids": [], "go_terms": [], "name": "DUF2799", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021243": {"description": "Protein of unknown function DUF2804", "go_ids": [], "go_terms": [], "name": "DUF2804", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021244": {"description": "Protein of unknown function DUF2802", "go_ids": [], "go_terms": [], "name": "DUF2802", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021245": {"description": "Protein of unknown function DUF2790", "go_ids": [], "go_terms": [], "name": "DUF2790", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021246": {"description": "Protein of unknown function DUF2797", "go_ids": [], "go_terms": [], "name": "DUF2797", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021247": {"description": "Protein of unknown function DUF2785", "go_ids": [], "go_terms": [], "name": "DUF2785", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021248": {"description": "Protein of unknown function DUF2787", "go_ids": [], "go_terms": [], "name": "DUF2787", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021249": {"description": "Protein of unknown function DUF2788", "go_ids": [], "go_terms": [], "name": "DUF2788", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021250": {"description": "Protein of unknown function DUF2789", "go_ids": [], "go_terms": [], "name": "DUF2789", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021251": {"description": "Protein of unknown function DUF2793", "go_ids": [], "go_terms": [], "name": "DUF2793", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021252": {"description": "Protein of unknown function DUF2794", "go_ids": [], "go_terms": [], "name": "DUF2794", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021253": {"description": "Zinc-specific solute binding protein ZrgA", "go_ids": [], "go_terms": [], "name": "ZrgA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021254": {"description": "Protein of unknown function DUF2806", "go_ids": [], "go_terms": [], "name": "DUF2806", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021255": {"description": "Putative auto-transporter adhesin, head GIN domain", "go_ids": [], "go_terms": [], "name": "DUF2807", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021256": {"description": "Protein of unknown function DUF2808", "go_ids": [], "go_terms": [], "name": "DUF2808", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021257": {"description": "Protein of unknown function DUF2809", "go_ids": [], "go_terms": [], "name": "DUF2809", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021258": {"description": "Epiplasmin protein", "go_ids": [], "go_terms": [], "name": "Epiplasmin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021259": {"description": "Protein of unknown function DUF2817", "go_ids": [], "go_terms": [], "name": "DUF2817", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021260": {"description": "Lipid II flippase Amj", "go_ids": [], "go_terms": [], "name": "Amj", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021261": {"description": "Glycerophosphocholine acyltransferase 1", "go_ids": [], "go_terms": [], "name": "GPCAT", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR021262": {"description": "Protein of unknown function DUF2839", "go_ids": [], "go_terms": [], "name": "DUF2839", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021263": {"description": "Protein of unknown function DUF2840", "go_ids": [], "go_terms": [], "name": "DUF2840", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021264": {"description": "Subtelomeric hrmA-associated cluster protein AFUB_079030/YDR124W-like", "go_ids": [], "go_terms": [], "name": "AFUB_079030/YDR124W-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021265": {"description": "Protein of unknown function DUF2842", "go_ids": [], "go_terms": [], "name": "DUF2842", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021266": {"description": "Kdo hydroxylase", "go_ids": [], "go_terms": [], "name": "Kdo_hydroxlase", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR021267": {"description": "Protein of unknown function DUF2844", "go_ids": [], "go_terms": [], "name": "DUF2844", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021268": {"description": "Protein of unknown function DUF2845", "go_ids": [], "go_terms": [], "name": "DUF2845", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021269": {"description": "Protein of unknown function DUF2848", "go_ids": [], "go_terms": [], "name": "DUF2848", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021270": {"description": "Protein of unknown function DUF2849", "go_ids": [], "go_terms": [], "name": "DUF2849", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021271": {"description": "Protein of unknown function DUF2850", "go_ids": [], "go_terms": [], "name": "DUF2850", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021272": {"description": "Protein of unknown function DUF2851", "go_ids": [], "go_terms": [], "name": "DUF2851", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021273": {"description": "Protein of unknown function DUF2852", "go_ids": [], "go_terms": [], "name": "DUF2852", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021274": {"description": "Protein of unknown function DUF2853", "go_ids": [], "go_terms": [], "name": "DUF2853", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021275": {"description": "Protein of unknown function DUF2854", "go_ids": [], "go_terms": [], "name": "DUF2854", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021276": {"description": "Protein of unknown function DUF2855", "go_ids": [], "go_terms": [], "name": "DUF2855", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021277": {"description": "Protein of unknown function DUF2610", "go_ids": [], "go_terms": [], "name": "DUF2610", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021278": {"description": "ATP synthase subunit K", "go_ids": [], "go_terms": [], "name": "ATP19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021279": {"description": "Protein of unknown function DUF2721", "go_ids": [], "go_terms": [], "name": "DUF2721", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021280": {"description": "Protein O-mannosyl-transferase TMEM260, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TMEM260_N", "pathway_ids": ["PWY-7922", "PWY-7921", "PWY-7979"], "pathways": ["PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-7979:t:protein O-mannosylation III (mammals, core M3)"], "type": "Domain"}, "IPR021281": {"description": "Small nuclear RNA activating complex subunit 2", "go_ids": ["GO:0009301", "GO:0016251"], "go_terms": ["GO:0009301:snRNA transcription:P", "GO:0016251:RNA polymerase II general transcription initiation factor activity:F"], "name": "SNAPC2", "pathway_ids": ["R-HSA-76071", "R-MMU-76071", "R-HSA-749476", "R-HSA-6807505", "R-MMU-6807505", "R-RNO-76071", "R-RNO-6807505"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR021282": {"description": "Dispersed gene family protein 1, domain 5", "go_ids": [], "go_terms": [], "name": "Dispersed_gene_fam_prot1_dom5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021283": {"description": "Bacteriophage baseplate wedge 1 protein", "go_ids": [], "go_terms": [], "name": "Phage_Wedge1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021284": {"description": "Protein of unknown function DUF2750", "go_ids": [], "go_terms": [], "name": "DUF2750", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021285": {"description": "Transcription regulator, HycA", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_HycA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021286": {"description": "Baculovirus, protein E26", "go_ids": [], "go_terms": [], "name": "Baculovirus_E26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021287": {"description": "Trans-sialidase, conserved site", "go_ids": [], "go_terms": [], "name": "Trans-sialidase_CS", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR021288": {"description": "Sporulated oocyst TA4 antigen", "go_ids": [], "go_terms": [], "name": "Surface_antigen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021289": {"description": "Recombination, repair and ssDNA binding protein UvsY", "go_ids": [], "go_terms": [], "name": "UvsY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021290": {"description": "Protein of unknown function DUF2861", "go_ids": [], "go_terms": [], "name": "DUF2861", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021291": {"description": "Cytochrome b6-f regulatory subunit PetP", "go_ids": [], "go_terms": [], "name": "Petp-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021292": {"description": "Protein of unknown function DUF2863", "go_ids": [], "go_terms": [], "name": "DUF2863", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021293": {"description": "Protein of unknown function DUF2865", "go_ids": [], "go_terms": [], "name": "DUF2865", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021294": {"description": "Protein of unknown function DUF2866", "go_ids": [], "go_terms": [], "name": "DUF2866", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021295": {"description": "Protein of unknown function DUF2867", "go_ids": [], "go_terms": [], "name": "DUF2867", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021296": {"description": "Protein of unknown function DUF2868", "go_ids": [], "go_terms": [], "name": "DUF2868", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021297": {"description": "YlqD protein", "go_ids": [], "go_terms": [], "name": "YlqD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021298": {"description": "Cilia- and flagella-associated protein 298", "go_ids": ["GO:0003352"], "go_terms": ["GO:0003352:regulation of cilium movement:P"], "name": "CFAP298", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021299": {"description": "Protein of unknown function DUF2871", "go_ids": [], "go_terms": [], "name": "DUF2871", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021300": {"description": "Integrating conjugative element protein, PFL4695", "go_ids": [], "go_terms": [], "name": "Integr_conj_element_PFL4695", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021301": {"description": "Domain of unknown functionDUF2779", "go_ids": [], "go_terms": [], "name": "DUF2779", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021302": {"description": "Protein of unknown function DUF2780, VcgC/VcgE", "go_ids": [], "go_terms": [], "name": "DUF2780_VcgC/VcgE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021303": {"description": "Uncharacterised protein family, inner membrane, YbhQ", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YbhQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021304": {"description": "Adenovirus L4-33K/L4-22K", "go_ids": ["GO:0019073"], "go_terms": ["GO:0019073:viral DNA genome packaging:P"], "name": "Adeno_L4-33K/L4-22K", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021305": {"description": "Protein of unknown function DUF2880", "go_ids": [], "go_terms": [], "name": "DUF2880", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021306": {"description": "Protein of unknown function DUF2878", "go_ids": [], "go_terms": [], "name": "DUF2878", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021307": {"description": "Protein of unknown function DUF2884", "go_ids": [], "go_terms": [], "name": "DUF2884", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021308": {"description": "Group 4 capsule polysaccharide formation lipoprotein GfcB", "go_ids": [], "go_terms": [], "name": "GfcB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021309": {"description": "Inner membrane protein YgaP-like, transmembrane domain", "go_ids": [], "go_terms": [], "name": "YgaP-like_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021310": {"description": "Plant viral coat protein nucleocapsid", "go_ids": [], "go_terms": [], "name": "Nucleocap_ssRNA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021311": {"description": "Rev protein of equine infectious anaemia virus", "go_ids": [], "go_terms": [], "name": "EIAV_Rev", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021312": {"description": "Protein of unknown function DUF2889", "go_ids": [], "go_terms": [], "name": "DUF2889", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021313": {"description": "Protein of unknown function DUF2909", "go_ids": [], "go_terms": [], "name": "DUF2909", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021314": {"description": "Protein of unknown function DUF2911", "go_ids": [], "go_terms": [], "name": "DUF2911", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021315": {"description": "Glycolipid exporter Gap/Sap", "go_ids": [], "go_terms": [], "name": "Gap/Sap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021316": {"description": "Protein of unknown function DUF2913", "go_ids": [], "go_terms": [], "name": "DUF2913", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021317": {"description": "Protein of unknown function DUF2917", "go_ids": [], "go_terms": [], "name": "DUF2917", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021318": {"description": "Protein of unknown function DUF2919", "go_ids": [], "go_terms": [], "name": "DUF2919", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021319": {"description": "SWEET-like domain", "go_ids": [], "go_terms": [], "name": "DUF2921", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR021320": {"description": "Protein of unknown function DUF2905", "go_ids": [], "go_terms": [], "name": "DUF2905", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021321": {"description": "Protein of unknown function DUF2922", "go_ids": [], "go_terms": [], "name": "DUF2922", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021322": {"description": "Protein of unknown function DUF2924", "go_ids": [], "go_terms": [], "name": "DUF2924", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021323": {"description": "Protein of unknown function DUF2927", "go_ids": [], "go_terms": [], "name": "DUF2927", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021324": {"description": "Protein of unknown function DUF2929", "go_ids": [], "go_terms": [], "name": "DUF2929", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021325": {"description": "Cofactor assembly of complex C subunit B, CCB2/CCB4", "go_ids": [], "go_terms": [], "name": "CCB2/CCB4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021326": {"description": "Protein of unknown function DUF2931", "go_ids": [], "go_terms": [], "name": "DUF2931", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021327": {"description": "Protein of unknown function DUF2934", "go_ids": [], "go_terms": [], "name": "DUF2934", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021328": {"description": "Spore coat protein CotB-like", "go_ids": [], "go_terms": [], "name": "CotB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021329": {"description": "Protein of unknown function DUF2938", "go_ids": [], "go_terms": [], "name": "DUF2938", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021330": {"description": "Protein of unknown function DUF2939", "go_ids": [], "go_terms": [], "name": "DUF2939", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021331": {"description": "Hypervirulence associated protein, TUDOR domain", "go_ids": [], "go_terms": [], "name": "Hva1_TUDOR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021332": {"description": "Protein of unknown function DUF2944", "go_ids": [], "go_terms": [], "name": "DUF2944", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021333": {"description": "Protein of unknown function DUF2946", "go_ids": [], "go_terms": [], "name": "DUF2946", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021334": {"description": "Protein of unknown function DUF2947", "go_ids": [], "go_terms": [], "name": "DUF2947", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021335": {"description": "Protein of unknown function DUF2948", "go_ids": [], "go_terms": [], "name": "DUF2948", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021336": {"description": "Protein of unknown function DUF2949", "go_ids": [], "go_terms": [], "name": "DUF2949", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021337": {"description": "Protein of unknown function DUF2951", "go_ids": [], "go_terms": [], "name": "DUF2951", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021338": {"description": "Protein of unknown function DUF2953", "go_ids": [], "go_terms": [], "name": "DUF2953", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021339": {"description": "Protein of unknown function DUF2956", "go_ids": [], "go_terms": [], "name": "DUF2956", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021340": {"description": "Protein of unknown function DUF2957", "go_ids": [], "go_terms": [], "name": "DUF2957", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021341": {"description": "Protein of unknown function DUF2958", "go_ids": [], "go_terms": [], "name": "DUF2958", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021342": {"description": "Protein of unknown function DUF2959", "go_ids": [], "go_terms": [], "name": "DUF2959", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021343": {"description": "Protein of unknown function DUF2960", "go_ids": [], "go_terms": [], "name": "DUF2960", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021344": {"description": "Protein of unknown function DUF2970", "go_ids": [], "go_terms": [], "name": "DUF2970", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021345": {"description": "GH172, second beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "DUF2961", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021346": {"description": "Translation machinery-associated protein 16", "go_ids": [], "go_terms": [], "name": "Tma16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021347": {"description": "Protein of unknown function DUF2964", "go_ids": [], "go_terms": [], "name": "DUF2964", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021348": {"description": "Domiain of unknown function DUF2963", "go_ids": [], "go_terms": [], "name": "DUF2963", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021349": {"description": "Protein of unknown function DUF2967", "go_ids": [], "go_terms": [], "name": "DUF2967", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021350": {"description": "Protein of unknown function DUF2968", "go_ids": [], "go_terms": [], "name": "DUF2968", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021351": {"description": "Protein of unknown function DUF2969", "go_ids": [], "go_terms": [], "name": "DUF2969", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021352": {"description": "Protein of unknown function DUF2971", "go_ids": [], "go_terms": [], "name": "DUF2971", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021353": {"description": "Protein of unknown function DUF2972", "go_ids": [], "go_terms": [], "name": "DUF2972", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021354": {"description": "Protein of unknown function DUF2975", "go_ids": [], "go_terms": [], "name": "DUF2975", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021355": {"description": "Bacteriophage Syn9, Gp224", "go_ids": [], "go_terms": [], "name": "Phage_Syn9_Gp224", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021356": {"description": "Integrating conjugative element protein PFL4702", "go_ids": [], "go_terms": [], "name": "Integr_conj_element_PFL4702", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021357": {"description": "Protein of unknown function DUF2782", "go_ids": [], "go_terms": [], "name": "DUF2782", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021358": {"description": "Protein of unknown function DUF2977", "go_ids": [], "go_terms": [], "name": "DUF2977", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021359": {"description": "Protein of unknown function DUF2812", "go_ids": [], "go_terms": [], "name": "DUF2812", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021361": {"description": "Thoeris anti-defense 2-like domain", "go_ids": [], "go_terms": [], "name": "Tad2-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021362": {"description": "Protein of unknown function DUF2834", "go_ids": [], "go_terms": [], "name": "DUF2834", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021363": {"description": "Protein of unknown function DUF2835", "go_ids": [], "go_terms": [], "name": "DUF2835", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021364": {"description": "Protein of unknown function DUF2857", "go_ids": [], "go_terms": [], "name": "DUF2857", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021365": {"description": "Protein of unknown function DUF2891", "go_ids": [], "go_terms": [], "name": "DUF2891", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021366": {"description": "Protein of unknown function DUF2981", "go_ids": [], "go_terms": [], "name": "DUF2981", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021367": {"description": "Protein of unknown function DUF2982", "go_ids": [], "go_terms": [], "name": "DUF2982", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021368": {"description": "Type VII secretion system protein EccE", "go_ids": [], "go_terms": [], "name": "T7SS_EccE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021369": {"description": "Protein of unknown function DUF2985", "go_ids": [], "go_terms": [], "name": "DUF2985", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021370": {"description": "Protein of unknown function DUF2987", "go_ids": [], "go_terms": [], "name": "DUF2987", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021372": {"description": "Protein of unknown function DUF2989", "go_ids": [], "go_terms": [], "name": "DUF2989", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021373": {"description": "Protein of unknown function DUF2993", "go_ids": [], "go_terms": [], "name": "DUF2993", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021374": {"description": "Protein of unknown function DUF2996", "go_ids": [], "go_terms": [], "name": "DUF2996", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021375": {"description": "Protein of unknown function DUF2997", "go_ids": [], "go_terms": [], "name": "DUF2997", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021376": {"description": "Protein of unknown function DUF2999", "go_ids": [], "go_terms": [], "name": "DUF2999", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021377": {"description": "Protein of unknown function DUF3006", "go_ids": [], "go_terms": [], "name": "DUF3006", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021378": {"description": "Protein of unknown function DUF3010", "go_ids": [], "go_terms": [], "name": "DUF3010", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021379": {"description": "Protein of unknown function DUF3012", "go_ids": [], "go_terms": [], "name": "DUF3012", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021380": {"description": "Protein of unknown function DUF3013", "go_ids": [], "go_terms": [], "name": "DUF3013", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021381": {"description": "Protein of unknown function DUF3011", "go_ids": [], "go_terms": [], "name": "DUF3011", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021382": {"description": "Protein of unknown function DUF3014", "go_ids": [], "go_terms": [], "name": "DUF3014", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021383": {"description": "Protein of unknown function DUF3015", "go_ids": [], "go_terms": [], "name": "DUF3015", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021384": {"description": "Mediator complex, subunit Med21", "go_ids": [], "go_terms": [], "name": "Mediator_Med21", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR021385": {"description": "Protein of unknown function DUF3017", "go_ids": [], "go_terms": [], "name": "DUF3017", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021386": {"description": "SPP41, DUF3020", "go_ids": [], "go_terms": [], "name": "SPP41_DUF3020", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021387": {"description": "Protein of unknown function DUF3023", "go_ids": [], "go_terms": [], "name": "DUF3023", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021388": {"description": "Protein of unknown function DUF3024", "go_ids": [], "go_terms": [], "name": "DUF3024", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021389": {"description": "Protein of unknown function DUF3022", "go_ids": [], "go_terms": [], "name": "DUF3022", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021390": {"description": "Protein of unknown function DUF3025", "go_ids": [], "go_terms": [], "name": "DUF3025", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021391": {"description": "Protein of unknown function DUF3027", "go_ids": [], "go_terms": [], "name": "DUF3027", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021392": {"description": "Focadhesin, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Focadhesin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021393": {"description": "Protein of unknown function DUF3034", "go_ids": [], "go_terms": [], "name": "DUF3034", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021394": {"description": "Mediator complex, subunit Med25, PTOV domain", "go_ids": [], "go_terms": [], "name": "Med25_PTOV", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR021395": {"description": "Protein of unknown function DUF3035", "go_ids": [], "go_terms": [], "name": "DUF3035", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021397": {"description": "Mediator complex, subunit Med25, synapsin 1", "go_ids": [], "go_terms": [], "name": "Mediator_Med25_SD1", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR021398": {"description": "Protein of unknown function DUF3037", "go_ids": [], "go_terms": [], "name": "DUF3037", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021399": {"description": "Protein of unknown function DUF3038", "go_ids": [], "go_terms": [], "name": "DUF3038", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021400": {"description": "Protein of unknown function DUF3039", "go_ids": [], "go_terms": [], "name": "DUF3039", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021401": {"description": "Protein of unknown function DUF3040", "go_ids": [], "go_terms": [], "name": "DUF3040", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021402": {"description": "Protein of unknown function DUF3042", "go_ids": [], "go_terms": [], "name": "DUF3042", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021403": {"description": "Protein of unknown function DUF3043", "go_ids": [], "go_terms": [], "name": "DUF3043", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021404": {"description": "Bacteriophage T4, Gp24.3", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp24.3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021405": {"description": "Bacteriophage T4, Gp30.1", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp30.1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021407": {"description": "Protein of unknown function DUF2544", "go_ids": [], "go_terms": [], "name": "DUF2544", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021408": {"description": "Protein of unknown function DUF3046", "go_ids": [], "go_terms": [], "name": "DUF3046", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021409": {"description": "Protein of unknown function DUF3047", "go_ids": [], "go_terms": [], "name": "DUF3047", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021410": {"description": "The fantastic four family", "go_ids": [], "go_terms": [], "name": "FAF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021411": {"description": "Sugarcane yellow leaf virus (SCYLV), Orf0", "go_ids": [], "go_terms": [], "name": "SCYLV_Orf0", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021412": {"description": "Protein of unknown function DUF3052", "go_ids": [], "go_terms": [], "name": "DUF3052", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021413": {"description": "Protein of unknown function DUF3053", "go_ids": [], "go_terms": [], "name": "DUF3053", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021414": {"description": "Protein of unknown function DUF3054", "go_ids": [], "go_terms": [], "name": "DUF3054", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021415": {"description": "SAV0927-like", "go_ids": [], "go_terms": [], "name": "SAV0927-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021416": {"description": "DUF3048, N-terminal", "go_ids": [], "go_terms": [], "name": "DUF3048_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021417": {"description": "Protein of unknown function DUF3060", "go_ids": [], "go_terms": [], "name": "DUF3060", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021418": {"description": "THO complex, subunitTHOC2, C-terminal", "go_ids": [], "go_terms": [], "name": "THO_THOC2_C", "pathway_ids": ["R-MMU-73856", "R-HSA-73856", "R-HSA-159236", "R-HSA-72187", "R-MMU-72187", "R-MMU-159236"], "pathways": ["R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR021419": {"description": "Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain", "go_ids": [], "go_terms": [], "name": "Mediator_Med25_VWA", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR021420": {"description": "Protein of unknown function DUF3067", "go_ids": [], "go_terms": [], "name": "DUF3067", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021421": {"description": "Domain of unknown function DUF3071", "go_ids": [], "go_terms": [], "name": "DUF3071", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021422": {"description": "Protein of unknown function DUF3069", "go_ids": [], "go_terms": [], "name": "DUF3069", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021424": {"description": "Porin PorA/Polar growth factor A", "go_ids": [], "go_terms": [], "name": "PorA/PgfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021425": {"description": "Protein of unknown function DUF3072", "go_ids": [], "go_terms": [], "name": "DUF3072", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021426": {"description": "Protein of unknown function DUF3073", "go_ids": [], "go_terms": [], "name": "DUF3073", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021427": {"description": "Protein of unknown function DUF3077", "go_ids": [], "go_terms": [], "name": "DUF3077", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021428": {"description": "Protein of unknown function DUF3078", "go_ids": [], "go_terms": [], "name": "DUF3078", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021429": {"description": "Mediator complex, subunit Med24,", "go_ids": ["GO:0016592"], "go_terms": ["GO:0016592:mediator complex:C"], "name": "Mediator_Med24", "pathway_ids": ["R-HSA-1989781", "R-RNO-9841922", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR021430": {"description": "Protein of unknown function DUF3079", "go_ids": [], "go_terms": [], "name": "DUF3079", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021431": {"description": "Protein of unknown function DUF3080", "go_ids": [], "go_terms": [], "name": "DUF3080", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021432": {"description": "Protein of unknown function DUF3081", "go_ids": [], "go_terms": [], "name": "DUF3081", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021433": {"description": "Protein of unknown function DUF3083", "go_ids": [], "go_terms": [], "name": "DUF3083", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021434": {"description": "Protein of unknown function DUF3082", "go_ids": [], "go_terms": [], "name": "DUF3082", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021435": {"description": "DUF3084, N-terminal", "go_ids": [], "go_terms": [], "name": "DUF3084_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021436": {"description": "Protein of unknown function DUF3085", "go_ids": [], "go_terms": [], "name": "DUF3085", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021437": {"description": "Protein of unknown function DUF3086", "go_ids": [], "go_terms": [], "name": "DUF3086", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021438": {"description": "Protein of unknown function DUF3087", "go_ids": [], "go_terms": [], "name": "DUF3087", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021439": {"description": "Protein of unknown function DUF3088", "go_ids": [], "go_terms": [], "name": "DUF3088", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021440": {"description": "Protein of unknown function DUF3089", "go_ids": [], "go_terms": [], "name": "DUF3089", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021441": {"description": "Protein of unknown function DUF3090", "go_ids": [], "go_terms": [], "name": "DUF3090", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021442": {"description": "Protein of unknown function DUF3091", "go_ids": [], "go_terms": [], "name": "DUF3091", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021443": {"description": "Protein of unknown function DUF3093", "go_ids": [], "go_terms": [], "name": "DUF3093", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021444": {"description": "Protein of unknown function DUF3094", "go_ids": [], "go_terms": [], "name": "DUF3094", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021445": {"description": "Protein of unknown function DUF3095", "go_ids": [], "go_terms": [], "name": "DUF3095", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021446": {"description": "Protein of unknown function DUF3096", "go_ids": [], "go_terms": [], "name": "DUF3096", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021447": {"description": "DUF3097, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF3097_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021448": {"description": "Protein of unknown function DUF3098", "go_ids": [], "go_terms": [], "name": "DUF3098", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021449": {"description": "Protein of unknown function DUF3099", "go_ids": [], "go_terms": [], "name": "DUF3099", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021450": {"description": "Protein of unknown function DUF3100", "go_ids": [], "go_terms": [], "name": "DUF3100", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021451": {"description": "Protein of unknown function DUF3102", "go_ids": [], "go_terms": [], "name": "DUF3102", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021452": {"description": "Protein of unknown function DUF3103", "go_ids": [], "go_terms": [], "name": "DUF3103", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021453": {"description": "Protein of unknown function DUF3104", "go_ids": [], "go_terms": [], "name": "DUF3104", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021454": {"description": "Domain of unknown function DUF3105", "go_ids": [], "go_terms": [], "name": "DUF3105", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021455": {"description": "Protein of unknown function DUF3106", "go_ids": [], "go_terms": [], "name": "DUF3106", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021456": {"description": "Protein of unknown function DUF3107", "go_ids": [], "go_terms": [], "name": "DUF3107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021457": {"description": "Protein of unknown function DUF3108", "go_ids": [], "go_terms": [], "name": "DUF3108", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021458": {"description": "Rv0495c-like", "go_ids": [], "go_terms": [], "name": "Rv0495c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021459": {"description": "Glycosyl hydrolases related to GH101 family, GHL1-GHL3", "go_ids": [], "go_terms": [], "name": "GH101-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021460": {"description": "Protein of unknown function DUF3112", "go_ids": [], "go_terms": [], "name": "DUF3112", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021461": {"description": "Protein of unknown function DUF3113", "go_ids": [], "go_terms": [], "name": "DUF3113", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021462": {"description": "Protein of unknown function DUF3114", "go_ids": [], "go_terms": [], "name": "DUF3114", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021463": {"description": "Putative SAM-dependent methyltransferase", "go_ids": [], "go_terms": [], "name": "Methyltransf_34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021464": {"description": "Protein of unknown function DUF3116", "go_ids": [], "go_terms": [], "name": "DUF3116", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021465": {"description": "Protein of unknown function DUF3117", "go_ids": [], "go_terms": [], "name": "DUF3117", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021466": {"description": "Putative rhamnosyl transferase", "go_ids": [], "go_terms": [], "name": "Put_rhamnosyl_transferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021467": {"description": "Protein of unknown function DUF3119", "go_ids": [], "go_terms": [], "name": "DUF3119", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021468": {"description": "Protein of unknown function DUF3120", "go_ids": [], "go_terms": [], "name": "DUF3120", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021469": {"description": "Protein of unknown function DUF3122", "go_ids": [], "go_terms": [], "name": "DUF3122", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021470": {"description": "Protein of unknown function DUF3123", "go_ids": [], "go_terms": [], "name": "DUF3123", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021471": {"description": "Protein of unknown function DUF3124", "go_ids": [], "go_terms": [], "name": "DUF3124", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021473": {"description": "Protein of unknown function DUF3126", "go_ids": [], "go_terms": [], "name": "DUF3126", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021474": {"description": "Protein of unknown function DUF3127", "go_ids": [], "go_terms": [], "name": "DUF3127", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021475": {"description": "Plasticity-Associated Neural Transcript Short/Early meiotic induction protein 1-like", "go_ids": [], "go_terms": [], "name": "Pants/Emi1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021476": {"description": "GAS1/GAS2/TsrA", "go_ids": [], "go_terms": [], "name": "GAS1/GAS2/TsrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021477": {"description": "Type VII secretion effector, SACOL2603 family", "go_ids": [], "go_terms": [], "name": "TVIIS_effector_SACOL2603_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021478": {"description": "Domain of unknown function DUF3131", "go_ids": [], "go_terms": [], "name": "DUF3131", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021479": {"description": "30K viral movement protein, C-terminal", "go_ids": [], "go_terms": [], "name": "30K_MP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021480": {"description": "Probable zinc-ribbon domain, plant", "go_ids": [], "go_terms": [], "name": "Zinc_ribbon_12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021481": {"description": "Protein of unknown function DUF3134", "go_ids": [], "go_terms": [], "name": "DUF3134", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021482": {"description": "Protein of unknown function DUF3135", "go_ids": [], "go_terms": [], "name": "DUF3135", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021483": {"description": "Protein of unknown function DUF3136", "go_ids": [], "go_terms": [], "name": "DUF3136", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021484": {"description": "Protein of unknown function DUF3137", "go_ids": [], "go_terms": [], "name": "DUF3137", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021485": {"description": "Protein of unknown function DUF3138", "go_ids": [], "go_terms": [], "name": "DUF3138", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021486": {"description": "Protein of unknown function DUF3139", "go_ids": [], "go_terms": [], "name": "DUF3139", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021487": {"description": "Protein of unknown function DUF3140", "go_ids": [], "go_terms": [], "name": "DUF3140", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021488": {"description": "Protein of unknown function DUF3142", "go_ids": [], "go_terms": [], "name": "DUF3142", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021489": {"description": "Protein of unknown function DUF3143", "go_ids": [], "go_terms": [], "name": "DUF3143", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021490": {"description": "Protein of unknown function DUF3144", "go_ids": [], "go_terms": [], "name": "DUF3144", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021491": {"description": "Protein of unknown function DUF3145", "go_ids": [], "go_terms": [], "name": "DUF3145", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021492": {"description": "Protein of unknown function DUF3146", "go_ids": [], "go_terms": [], "name": "DUF3146", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021493": {"description": "Protein of unknown function DUF3147", "go_ids": [], "go_terms": [], "name": "DUF3147", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021494": {"description": "Protein of unknown function DUF3149", "go_ids": [], "go_terms": [], "name": "DUF3149", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021495": {"description": "Protein CHLORORESPIRATORY REDUCTION 42-like", "go_ids": ["GO:0010258"], "go_terms": ["GO:0010258:NADH dehydrogenase complex (plastoquinone) assembly:P"], "name": "CRR42-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021496": {"description": "Protein of unknown function DUF3150", "go_ids": [], "go_terms": [], "name": "DUF3150", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021497": {"description": "Holin of 3TMs, for gene-transfer release", "go_ids": [], "go_terms": [], "name": "GTA_holin_3TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021498": {"description": "Protein of unknown function DUF3155", "go_ids": [], "go_terms": [], "name": "DUF3155", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021499": {"description": "Protein of unknown function DUF3153", "go_ids": [], "go_terms": [], "name": "DUF3153", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021500": {"description": "Protein of unknown function DUF3156", "go_ids": [], "go_terms": [], "name": "DUF3156", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021501": {"description": "Protein of unknown function DUF3157", "go_ids": [], "go_terms": [], "name": "DUF3157", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021502": {"description": "Protein of unknown function DUF3158", "go_ids": [], "go_terms": [], "name": "DUF3158", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021503": {"description": "Protein of unknown function DUF3110", "go_ids": [], "go_terms": [], "name": "DUF3110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021505": {"description": "Bacteriophage B3, Orf6", "go_ids": [], "go_terms": [], "name": "Phage_B3_Orf6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021506": {"description": "Protein of unknown function DUF3165", "go_ids": [], "go_terms": [], "name": "DUF3165", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021508": {"description": "Tail completion protein gp17", "go_ids": [], "go_terms": [], "name": "Gp17-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021509": {"description": "Protein of unknown function DUF3169", "go_ids": [], "go_terms": [], "name": "DUF3169", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021511": {"description": "Protein of unknown function DUF3172", "go_ids": [], "go_terms": [], "name": "DUF3172", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021512": {"description": "Protein of unknown function DUF3173", "go_ids": [], "go_terms": [], "name": "DUF3173", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021513": {"description": "Ralstonia phage RSL1, Orf186", "go_ids": [], "go_terms": [], "name": "Phage_RSL1_Orf186", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021514": {"description": "Protein of unknown function DUF3176", "go_ids": [], "go_terms": [], "name": "DUF3176", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021515": {"description": "Protein of unknown function DUF3177", "go_ids": [], "go_terms": [], "name": "DUF3177", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021516": {"description": "Protein of unknown function DUF3179", "go_ids": [], "go_terms": [], "name": "DUF3179", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021517": {"description": "Protein of unknown function DUF3180", "go_ids": [], "go_terms": [], "name": "DUF3180", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021518": {"description": "Protein of unknown function DUF3181", "go_ids": [], "go_terms": [], "name": "DUF3181", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021519": {"description": "Protein of unknown function DUF3182", "go_ids": [], "go_terms": [], "name": "DUF3182", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021520": {"description": "Stealth protein CR2, conserved region 2", "go_ids": ["GO:0016772"], "go_terms": ["GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "Stealth_CR2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021521": {"description": "Protein of unknown function DUF3185", "go_ids": [], "go_terms": [], "name": "DUF3185", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021522": {"description": "Copper transporter MctB", "go_ids": ["GO:0016020", "GO:0055070"], "go_terms": ["GO:0016020:membrane:C", "GO:0055070:copper ion homeostasis:P"], "name": "MctB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021523": {"description": "Protein of unknown function DUF3187", "go_ids": [], "go_terms": [], "name": "DUF3187", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021524": {"description": "Protein of unknown function DUF3188", "go_ids": [], "go_terms": [], "name": "DUF3188", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021525": {"description": "Protein of unknown function DUF3189", "go_ids": [], "go_terms": [], "name": "DUF3189", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021526": {"description": "Vitelline envelope, lysin receptor", "go_ids": [], "go_terms": [], "name": "Vitelline_env_lysin-recpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021527": {"description": "Protein of unknown function DUF2795", "go_ids": [], "go_terms": [], "name": "DUF2795", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021528": {"description": "Phagosome trafficking protein DotA", "go_ids": [], "go_terms": [], "name": "DotA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021529": {"description": "Protein of unknown function DUF2798", "go_ids": [], "go_terms": [], "name": "DUF2798", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021530": {"description": "AllH-like, C-terminal", "go_ids": [], "go_terms": [], "name": "AllH-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021531": {"description": "Type VI lipase adapter protein Tla3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Tla3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021532": {"description": "Structural accessory protein ORF7b, betacoronavirus", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "NS7B_bCoV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021533": {"description": "Putative beta-lactamase-inhibitor-like, PepSY-like", "go_ids": [], "go_terms": [], "name": "PepSY-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021534": {"description": "Protein of unknown function DUF3192", "go_ids": [], "go_terms": [], "name": "DUF3192", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021535": {"description": "Tetrabrachion", "go_ids": [], "go_terms": [], "name": "Tetrabrachion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021536": {"description": "DNA ligase IV domain", "go_ids": ["GO:0003910"], "go_terms": ["GO:0003910:DNA ligase (ATP) activity:F"], "name": "DNA_ligase_IV_dom", "pathway_ids": ["R-HSA-5693571", "R-GGA-353423", "R-MMU-5693571", "R-DDI-5693571", "R-HSA-164843"], "pathways": ["R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Domain"}, "IPR021537": {"description": "Hypoxia-inducible factor, alpha subunit-like", "go_ids": [], "go_terms": [], "name": "HIF_alpha-like", "pathway_ids": ["R-MMU-1234174", "R-RNO-1234176", "R-HSA-1234174", "R-HSA-1234158", "R-HSA-8951664", "R-HSA-5689880", "R-RNO-1234174", "R-HSA-452723", "R-HSA-6785807", "R-MMU-1234176", "R-RNO-5689880", "R-MMU-8951664", "R-MMU-1234158", "R-MMU-5689880", "R-HSA-9909649", "R-RNO-8951664", "R-HSA-8849473", "R-RNO-1234158", "R-HSA-2122947", "R-RNO-8857538", "R-HSA-9701898", "R-MMU-8857538", "R-HSA-8857538", "R-HSA-9664873", "R-HSA-1234176"], "pathways": ["R-MMU-1234174:r:Cellular response to hypoxia", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1234174:r:Cellular response to hypoxia", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-1234174:r:Cellular response to hypoxia", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-8951664:r:Neddylation", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-8951664:r:Neddylation", "R-HSA-8849473:r:PTK6 Expression", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9664873:r:Pexophagy", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Domain"}, "IPR021538": {"description": "Syntaxin-5, N-terminal, Sly1p-binding domain", "go_ids": [], "go_terms": [], "name": "Syntaxin-5_N", "pathway_ids": ["R-SPO-6807878", "R-MMU-204005", "R-HSA-6811438", "R-MMU-6811438", "R-MMU-9013106", "R-MMU-5694530", "R-MMU-8980692", "R-RNO-8980692", "R-SCE-204005", "R-MMU-9013408", "R-HSA-9013106", "R-MMU-6807878", "R-RNO-9609523", "R-HSA-5694530", "R-BTA-9609523", "R-BTA-6807878", "R-CEL-9609523", "R-SCE-5694530", "R-CEL-204005", "R-RNO-9013408", "R-RNO-9013106", "R-BTA-204005", "R-HSA-9609523", "R-HSA-9013408", "R-CEL-6811438", "R-MMU-9609523", "R-RNO-5694530", "R-SCE-6807878", "R-CEL-5694530", "R-RNO-6807878", "R-RNO-6811438", "R-HSA-6807878", "R-SPO-204005", "R-CEL-6807878", "R-SPO-5694530", "R-RNO-204005", "R-SCE-9013106", "R-BTA-9013408", "R-HSA-204005", "R-HSA-8980692", "R-SPO-6811438", "R-BTA-5694530", "R-SPO-9609523", "R-SCE-6811438", "R-BTA-8980692", "R-SCE-9609523", "R-BTA-6811438", "R-BTA-9013106"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-5694530:r:Cargo concentration in the ER", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-5694530:r:Cargo concentration in the ER", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-6811438:r:Intra-Golgi traffic", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-5694530:r:Cargo concentration in the ER", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-CEL-5694530:r:Cargo concentration in the ER", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-SPO-5694530:r:Cargo concentration in the ER", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-SCE-9013106:r:RHOC GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SPO-6811438:r:Intra-Golgi traffic", "R-BTA-5694530:r:Cargo concentration in the ER", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-6811438:r:Intra-Golgi traffic", "R-BTA-8980692:r:RHOA GTPase cycle", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-6811438:r:Intra-Golgi traffic", "R-BTA-9013106:r:RHOC GTPase cycle"], "type": "Domain"}, "IPR021539": {"description": "Bacteriocin subtilosin A", "go_ids": [], "go_terms": [], "name": "Subtilosin_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021540": {"description": "PAE0736-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PAE0736-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021542": {"description": "Tn7 transposition regulator TnsC", "go_ids": [], "go_terms": [], "name": "Tn7_TnsC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021543": {"description": "Programmed cell death activator EGL-1", "go_ids": [], "go_terms": [], "name": "EGL-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021544": {"description": "Vanadium-binding protein 2", "go_ids": [], "go_terms": [], "name": "Vanabin-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021545": {"description": "Type III secretion system filament chaperone CesA", "go_ids": [], "go_terms": [], "name": "CesA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021546": {"description": "Pilot protein MxiM", "go_ids": [], "go_terms": [], "name": "MxiM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021547": {"description": "Protein of unknown function DUF2826", "go_ids": [], "go_terms": [], "name": "DUF2826", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021548": {"description": "Protein of unknown function DUF2895", "go_ids": [], "go_terms": [], "name": "DUF2895", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021549": {"description": "Protein of unknown function DUF2894", "go_ids": [], "go_terms": [], "name": "DUF2894", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021550": {"description": "Protein of unknown function DUF2897", "go_ids": [], "go_terms": [], "name": "DUF2897", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021551": {"description": "Protein of unknown function DUF3005", "go_ids": [], "go_terms": [], "name": "DUF3005", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021552": {"description": "Putative, 10TM heavy-metal exporter", "go_ids": [], "go_terms": [], "name": "ArsP_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021553": {"description": "Protein of unknwon function DUF3008", "go_ids": [], "go_terms": [], "name": "DUF3008", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021555": {"description": "Protein of unknown function DUF3000", "go_ids": [], "go_terms": [], "name": "DUF3000", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021556": {"description": "Protein of unknown function DUF2950", "go_ids": [], "go_terms": [], "name": "DUF2950", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021557": {"description": "Protein of unknown function DUF3016", "go_ids": [], "go_terms": [], "name": "DUF3016", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021558": {"description": "Antitoxin MazE-like", "go_ids": [], "go_terms": [], "name": "MazE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021559": {"description": "Protein of unknown function DUF3019", "go_ids": [], "go_terms": [], "name": "DUF3019", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021560": {"description": "Protein of unknown function DUF3021", "go_ids": [], "go_terms": [], "name": "DUF3021", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021561": {"description": "Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system", "go_ids": [], "go_terms": [], "name": "AbiEi_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021562": {"description": "Protein of unknown function DUF3007", "go_ids": [], "go_terms": [], "name": "DUF3007", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021563": {"description": "Rab interacting lysosomal protein, dimerization domain", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "RILP_dimer", "pathway_ids": ["R-HSA-2132295", "R-MMU-2132295"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-MMU-2132295:r:MHC class II antigen presentation"], "type": "Domain"}, "IPR021564": {"description": "Protein of unknown function DUF3203", "go_ids": [], "go_terms": [], "name": "DUF3203", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021565": {"description": "Rabenosyn, Rab binding domain", "go_ids": [], "go_terms": [], "name": "Rbsn_Rab-bd", "pathway_ids": ["R-HSA-983231", "R-HSA-168138", "R-MMU-168138", "R-MMU-983231", "R-SCE-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR021566": {"description": "Prion-like protein Doppel", "go_ids": [], "go_terms": [], "name": "Doppel", "pathway_ids": ["R-MMU-163125", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR021567": {"description": "Lens epithelium-derived growth factor, integrase-binding domain", "go_ids": [], "go_terms": [], "name": "LEDGF_IBD", "pathway_ids": ["R-BTA-9772755", "R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-9772755", "R-RNO-9772755", "R-HSA-175567", "R-MMU-9772755", "R-HSA-180689", "R-HSA-164843"], "pathways": ["R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation"], "type": "Domain"}, "IPR021568": {"description": "Ribonuclease III, archaeal", "go_ids": [], "go_terms": [], "name": "Ribonuclease_III_archaeal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021569": {"description": "TUG ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "TUG-UBL1", "pathway_ids": ["R-HSA-1445148"], "pathways": ["R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "type": "Domain"}, "IPR021570": {"description": "LamB-type porin N-terminal domain", "go_ids": [], "go_terms": [], "name": "LamB-type_porin_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021571": {"description": "Protein of unknown function DUF3206", "go_ids": [], "go_terms": [], "name": "DUF3206", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021573": {"description": "Leader peptide, picornavirus", "go_ids": [], "go_terms": [], "name": "Leader_pept_picornaV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021574": {"description": "Sialyltransferase PMO188-like", "go_ids": [], "go_terms": [], "name": "PM0188-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021575": {"description": "RNA silencing suppressor P21, C-terminal", "go_ids": [], "go_terms": [], "name": "Suppressor_P21_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021576": {"description": "Protein of unknown function DUF3208", "go_ids": [], "go_terms": [], "name": "DUF3208", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021577": {"description": "Protein of unknown function DUF3209", "go_ids": [], "go_terms": [], "name": "DUF3209", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021578": {"description": "STK_08120-like", "go_ids": [], "go_terms": [], "name": "STK_08120-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021579": {"description": "Protein of unknown function DUF3212", "go_ids": [], "go_terms": [], "name": "DUF3212", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021580": {"description": "Type II restriction enzyme SfiI", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_SfiI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021581": {"description": "Transcription regulator LGE1, helical region", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_Lge1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021582": {"description": "Altered inheritance of mitochondria protein 21", "go_ids": [], "go_terms": [], "name": "Aim21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021583": {"description": "Protein of unknown function DUF3213", "go_ids": [], "go_terms": [], "name": "DUF3213", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021584": {"description": "Thylakoid soluble phosphoprotein TSP9", "go_ids": [], "go_terms": [], "name": "TSP9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021585": {"description": "Ta0938", "go_ids": [], "go_terms": [], "name": "Ta0938", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021586": {"description": "Transcription regulator TrmB, C-terminal", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_TrmB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021587": {"description": "Transcription activator LAG-3", "go_ids": [], "go_terms": [], "name": "Transcription_activator_LAG-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021589": {"description": "Spindle pole body-associated protein cut12", "go_ids": [], "go_terms": [], "name": "Cut12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021590": {"description": "NSP1, globular domain, betacoronavirus", "go_ids": [], "go_terms": [], "name": "NSP1_glob_bCoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR021591": {"description": "YNR034W-A/EGO2", "go_ids": [], "go_terms": [], "name": "YNR034W-A/EGO2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021593": {"description": "Protein of unknown function DUF3218", "go_ids": [], "go_terms": [], "name": "DUF3218", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021595": {"description": "Thermoplasma acidophilum protein TA0956", "go_ids": [], "go_terms": [], "name": "TA0956", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021596": {"description": "Protein of unknown function DUF3219", "go_ids": [], "go_terms": [], "name": "DUF3219", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021597": {"description": "Protein of unknown function DUF3220", "go_ids": [], "go_terms": [], "name": "DUF3220", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021598": {"description": "Protein of unknown function DUF3221", "go_ids": [], "go_terms": [], "name": "DUF3221", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021599": {"description": "Protein of unknown function DUF3222", "go_ids": [], "go_terms": [], "name": "DUF3222", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021600": {"description": "Transcription factor TFIIE alpha subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "TFIIE_asu_C", "pathway_ids": ["R-BTA-75953", "R-HSA-6807505", "R-BTA-73776", "R-BTA-73779", "R-MMU-75953", "R-MMU-73779", "R-BTA-76042", "R-BTA-674695", "R-MMU-674695", "R-MMU-6807505", "R-HSA-167162", "R-HSA-167161", "R-HSA-73776", "R-HSA-75953", "R-MMU-73776", "R-HSA-674695", "R-HSA-76042", "R-BTA-6807505", "R-HSA-167172", "R-MMU-76042", "R-HSA-73779"], "pathways": ["R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR021601": {"description": "Phosphatidylinositol 4-kinase, Pik1, helix hairpin, fungi", "go_ids": [], "go_terms": [], "name": "Pik1_hairpin", "pathway_ids": ["PWY-6351", "PWY-6352", "R-SCE-1660514", "R-SPO-1660514"], "pathways": ["PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane"], "type": "Domain"}, "IPR021603": {"description": "Selenium-binding protein, archaea", "go_ids": [], "go_terms": [], "name": "SeBP_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021604": {"description": "Copper resistance protein K", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "CopK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021605": {"description": "Pcf11, Clp1-ID", "go_ids": ["GO:0031124", "GO:0006369", "GO:0005849"], "go_terms": ["GO:0031124:mRNA 3'-end processing:P", "GO:0006369:termination of RNA polymerase II transcription:P", "GO:0005849:mRNA cleavage factor complex:C"], "name": "Pcf11_Clp1-ID", "pathway_ids": ["R-HSA-77595", "R-SCE-9770562", "R-SPO-9770562", "R-MMU-72187", "R-HSA-6807505", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-77595", "R-MMU-73856", "R-HSA-73856", "R-HSA-72187", "R-HSA-9918481", "R-MMU-6807505"], "pathways": ["R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SCE-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR021607": {"description": "Protein of unknown function DUF3224", "go_ids": [], "go_terms": [], "name": "DUF3224", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021608": {"description": "Melampsora lini avirulence protein AvrL567", "go_ids": [], "go_terms": [], "name": "AvrL567", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021609": {"description": "Nitrosopumilus output domain 5", "go_ids": [], "go_terms": [], "name": "NitrOD5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021610": {"description": "Protein of unknown function DUF3228", "go_ids": [], "go_terms": [], "name": "DUF3228", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021611": {"description": "Spindle pole body component Spc42", "go_ids": [], "go_terms": [], "name": "Spc42", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021612": {"description": "Staphylococcal complement inhibitor SCIN", "go_ids": [], "go_terms": [], "name": "SCIN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021613": {"description": "Protein-tyrosine phosphatase receptor IA-2 ectodomain", "go_ids": [], "go_terms": [], "name": "Receptor_IA-2_dom", "pathway_ids": ["R-MMU-6798695", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR021614": {"description": "Protein transport protein SEC31, conserved region", "go_ids": [], "go_terms": [], "name": "Sec31", "pathway_ids": ["R-SCE-204005"], "pathways": ["R-SCE-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR021615": {"description": "Outer membrane protein Omp28", "go_ids": [], "go_terms": [], "name": "Omp28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021617": {"description": "Protein of unknown function DUF3231", "go_ids": [], "go_terms": [], "name": "DUF3231", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021618": {"description": "Protein of unknown function DUF3232", "go_ids": [], "go_terms": [], "name": "DUF3232", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021619": {"description": "Mig-6 domain", "go_ids": [], "go_terms": [], "name": "Mig-6", "pathway_ids": ["R-RNO-9842663", "R-HSA-9842663", "R-MMU-9842663"], "pathways": ["R-RNO-9842663:r:Signaling by LTK", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-9842663:r:Signaling by LTK"], "type": "Domain"}, "IPR021620": {"description": "Erythrocyte binding antigen 175, C-terminal", "go_ids": [], "go_terms": [], "name": "EBA-175_C", "pathway_ids": ["R-HSA-202733"], "pathways": ["R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR021621": {"description": "Solitary outer membrane autotransporter-like, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "Omp_AT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021622": {"description": "Afadin/alpha-actinin-binding", "go_ids": [], "go_terms": [], "name": "Afadin/alpha-actinin-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021623": {"description": "Lamina-associated polypeptide 2 alpha, C-terminal", "go_ids": [], "go_terms": [], "name": "LAP2alpha_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021624": {"description": "Single-strand annealing weakened protein 1", "go_ids": ["GO:0070336", "GO:0000736"], "go_terms": ["GO:0070336:flap-structured DNA binding:F", "GO:0000736:double-strand break repair via single-strand annealing, removal of nonhomologous ends:P"], "name": "Saw1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021625": {"description": "PI31 proteasome regulator, N-terminal", "go_ids": [], "go_terms": [], "name": "PI31_Prot_N", "pathway_ids": ["R-MMU-8951664", "R-HSA-9907900", "R-HSA-983168", "R-RNO-983168", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-9907900:r:Proteasome assembly", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR021626": {"description": "Plasmodium falciparum UIS3 membrane protein", "go_ids": [], "go_terms": [], "name": "PfUIS3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021627": {"description": "Mediator complex, subunit Med27", "go_ids": ["GO:0016592"], "go_terms": ["GO:0016592:mediator complex:C"], "name": "Mediator_Med27", "pathway_ids": ["R-HSA-1989781", "R-BTA-9841922", "R-DME-9841922", "R-SSC-9841922", "R-HSA-381340", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SSC-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Family"}, "IPR021628": {"description": "Protein of unknown function DUF3234", "go_ids": [], "go_terms": [], "name": "DUF3234", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021629": {"description": "Mediator complex, subunit Med23", "go_ids": [], "go_terms": [], "name": "Mediator_Med23", "pathway_ids": ["R-RNO-9841922", "R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR021630": {"description": "Resuscitation-promoting factor Rpf1, C-terminal", "go_ids": [], "go_terms": [], "name": "Rpf1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021631": {"description": "Protein of unknown function DUF3238", "go_ids": [], "go_terms": [], "name": "DUF3238", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021632": {"description": "Protein of unknown function DUF3239", "go_ids": [], "go_terms": [], "name": "DUF3239", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021633": {"description": "Antagonist of EGFR signalling, Argos", "go_ids": [], "go_terms": [], "name": "Argos", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021634": {"description": "Protein of unknown function DUF3240", "go_ids": [], "go_terms": [], "name": "DUF3240", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021635": {"description": "Proteinaceous host-selective toxin ToxA", "go_ids": [], "go_terms": [], "name": "Toxin_ToxA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021636": {"description": "Protein of unknown function DUF3242", "go_ids": [], "go_terms": [], "name": "DUF3242", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021637": {"description": "Protein of unknown function DUF3243", "go_ids": [], "go_terms": [], "name": "DUF3243", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021638": {"description": "Protein of unknown function DUF3244", "go_ids": [], "go_terms": [], "name": "DUF3244", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021639": {"description": "DNA polymerase catalytic subunit Pol, C-terminal", "go_ids": ["GO:0004523", "GO:0003887"], "go_terms": ["GO:0004523:RNA-DNA hybrid ribonuclease activity:F", "GO:0003887:DNA-directed DNA polymerase activity:F"], "name": "DNAPolymera_Pol_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021640": {"description": "Mediator complex, subunit Med28", "go_ids": [], "go_terms": [], "name": "Mediator_Med28", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR021641": {"description": "Protein of unknown function DUF3245", "go_ids": [], "go_terms": [], "name": "DUF3245", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021642": {"description": "Protein of unknown function DUF3246", "go_ids": [], "go_terms": [], "name": "DUF3246", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021643": {"description": "Mediator complex, subunit Med13, N-terminal", "go_ids": [], "go_terms": [], "name": "Mediator_Med13_N", "pathway_ids": ["R-HSA-1989781", "R-DME-9841922", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR021644": {"description": "Chromatin assembly factor 1 p150 subunit, acidic region", "go_ids": [], "go_terms": [], "name": "CAF-1_p150_acidic", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021645": {"description": "Shal-type voltage-gated potassium channels, N-terminal", "go_ids": [], "go_terms": [], "name": "Shal-type_N", "pathway_ids": ["R-DME-1296072", "R-MMU-5576894", "R-BTA-1296072", "R-RNO-5576894", "R-HSA-1296072", "R-BTA-5576894", "R-DME-5576894", "R-HSA-5576894", "R-RNO-1296072", "R-MMU-1296072"], "pathways": ["R-DME-1296072:r:Voltage gated Potassium channels", "R-MMU-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-RNO-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-BTA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-DME-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-MMU-1296072:r:Voltage gated Potassium channels"], "type": "Domain"}, "IPR021646": {"description": "Sir1, ORC-binding domain", "go_ids": [], "go_terms": [], "name": "Sir1_ORC-binding", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021647": {"description": "Copper binding periplasmic protein CusF", "go_ids": [], "go_terms": [], "name": "CusF_Ec", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021648": {"description": "Vacuolar protein sorting protein 36, GLUE domain", "go_ids": ["GO:0043130", "GO:0032266"], "go_terms": ["GO:0043130:ubiquitin binding:F", "GO:0032266:phosphatidylinositol-3-phosphate binding:F"], "name": "GLUE_dom", "pathway_ids": ["R-RNO-917729", "R-HSA-917729", "R-HSA-9610379", "R-DRE-917729", "R-DME-917729", "R-MMU-917729", "R-SPO-917729", "R-DDI-917729", "R-SCE-917729"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SPO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Domain"}, "IPR021649": {"description": "Protein of unknown function DUF3247", "go_ids": [], "go_terms": [], "name": "DUF3247", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021650": {"description": "Protein of unknown function DUF3248", "go_ids": [], "go_terms": [], "name": "DUF3248", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021651": {"description": "Scaffold protein Ste5, Fus3-binding domain", "go_ids": ["GO:0019900"], "go_terms": ["GO:0019900:kinase binding:F"], "name": "Ste5_Fus-binding", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021653": {"description": "CCR4-associated factor 4", "go_ids": ["GO:0000266", "GO:0005739"], "go_terms": ["GO:0000266:mitochondrial fission:P", "GO:0005739:mitochondrion:C"], "name": "Caf4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021654": {"description": "Histone-lysine N-methyltransferase EZH1/EZH2, N-terminal", "go_ids": ["GO:0046976"], "go_terms": ["GO:0046976:histone H3K27 methyltransferase activity:F"], "name": "EZH1/EZH2_N", "pathway_ids": ["R-MMU-8953750", "R-MMU-3214841", "R-HSA-2559580", "R-DRE-2559580", "R-XTR-212300", "R-XTR-9764725", "R-DRE-8953750", "R-HSA-9764725", "R-MMU-212300", "R-HSA-9609690", "R-HSA-8953750", "R-MMU-9764725", "R-MMU-2559580", "R-MMU-8943724", "R-HSA-9710421", "R-XTR-8953750", "R-HSA-212300", "R-HSA-9909649", "R-XTR-9909649", "R-DRE-3214841", "R-HSA-3214841", "R-MMU-9909649", "R-BTA-212300", "R-HSA-8943724", "R-XTR-2559580", "R-DRE-212300", "R-DRE-9909649", "R-HSA-5617472", "R-DRE-9764725"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9710421:r:Defective pyroptosis", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription"], "type": "Domain"}, "IPR021655": {"description": "Putative metal-binding motif", "go_ids": [], "go_terms": [], "name": "Put_metal-bd", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR021656": {"description": "RPGR-interacting protein 1, first C2 domain", "go_ids": [], "go_terms": [], "name": "C2-C2_1", "pathway_ids": ["R-HSA-5610787", "R-MMU-5610787", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR021657": {"description": "Immunoglobulin-binding protein Sbi, domain IV", "go_ids": [], "go_terms": [], "name": "IgG-binding_Sbi_dom_IV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021658": {"description": "Domain of unknown function DUF3251", "go_ids": [], "go_terms": [], "name": "DUF3251", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021659": {"description": "NADH dehydrogenase-like complex, subunit S", "go_ids": ["GO:0009767"], "go_terms": ["GO:0009767:photosynthetic electron transport chain:P"], "name": "NdhS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021660": {"description": "Protein of unknown function DUF3253", "go_ids": [], "go_terms": [], "name": "DUF3253", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021661": {"description": "TRF2-interacting telomeric protein/Rap1, C-terminal", "go_ids": [], "go_terms": [], "name": "Rap1_C", "pathway_ids": ["R-BTA-174411", "R-MMU-174430", "R-RNO-174437", "R-HSA-174414", "R-MMU-174417", "R-BTA-174437", "R-XTR-171319", "R-BTA-174417", "R-HSA-1221632", "R-RNO-171319", "R-MMU-110331", "R-MMU-9670095", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-XTR-110330", "R-MMU-174414", "R-BTA-174430", "R-DRE-110331", "R-DRE-174430", "R-RNO-110330", "R-MMU-174437", "R-XTR-2559586", "R-HSA-110329", "R-HSA-110330", "R-BTA-110330", "R-RNO-174411", "R-BTA-9670095", "R-RNO-2559586", "R-MMU-110330", "R-HSA-171306", "R-DRE-110330", "R-MMU-2559586", "R-RNO-174430", "R-BTA-171306", "R-RNO-110331", "R-HSA-174430", "R-HSA-110328", "R-DRE-171319", "R-HSA-174411", "R-DRE-174437", "R-XTR-110331", "R-MMU-171319", "R-BTA-171319", "R-BTA-2559586", "R-XTR-171306", "R-HSA-9670095", "R-BTA-110331", "R-GGA-418124", "R-RNO-174417", "R-BTA-174414", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586", "R-RNO-174414"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-171319:r:Telomere Extension By Telomerase", "R-BTA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-1221632:r:Meiotic synapsis", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-XTR-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-DRE-110331:r:Cleavage of the damaged purine", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-BTA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-9670095:r:Inhibition of DNA recombination at telomere", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-DRE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-BTA-171306:r:Packaging Of Telomere Ends", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DRE-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-110331:r:Cleavage of the damaged purine", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-BTA-171319:r:Telomere Extension By Telomerase", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-XTR-171306:r:Packaging Of Telomere Ends", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-BTA-110331:r:Cleavage of the damaged purine", "R-GGA-418124:r:Telomere maintenance", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere"], "type": "Domain"}, "IPR021662": {"description": "Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal", "go_ids": [], "go_terms": [], "name": "HnRNPA1/A2_C", "pathway_ids": ["R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-RNO-72203", "R-MMU-9770562", "R-MMU-72163", "R-HSA-6803529", "R-RNO-72163", "R-HSA-8950505", "R-HSA-9735869", "R-HSA-72163", "R-BTA-6803529", "R-RNO-9770562", "R-BTA-9770562", "R-BTA-72203", "R-HSA-9692914", "R-RNO-6803529", "R-HSA-9918481", "R-MMU-6803529", "R-BTA-72163"], "pathways": ["R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR021663": {"description": "T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit", "go_ids": [], "go_terms": [], "name": "CD3_zeta/IgE_Fc_rcpt_gamma", "pathway_ids": ["R-HSA-6798695", "R-MMU-114604", "R-HSA-202433", "R-RNO-5621480", "R-HSA-2871796", "R-HSA-2029485", "R-BTA-6798695", "R-HSA-2029481", "R-RNO-2871809", "R-RNO-75892", "R-MMU-202430", "R-MMU-2871796", "R-HSA-2454202", "R-HSA-202427", "R-HSA-2871837", "R-BTA-75892", "R-BTA-2871837", "R-BTA-2871809", "R-MMU-75892", "R-BTA-2871796", "R-HSA-164944", "R-BTA-2454202", "R-HSA-2730905", "R-HSA-202430", "R-HSA-5621480", "R-MMU-5621480", "R-HSA-114604", "R-MMU-202424", "R-MMU-389948", "R-MMU-202433", "R-HSA-2871809", "R-HSA-2029482", "R-MMU-2454202", "R-RNO-114604", "R-HSA-75892", "R-BTA-2730905", "R-RNO-2454202", "R-MMU-198933", "R-MMU-2871837", "R-MMU-2871809", "R-HSA-389948", "R-BTA-5621480", "R-RNO-2730905", "R-BTA-114604", "R-MMU-6798695", "R-MMU-2730905", "R-HSA-198933", "R-MMU-202427", "R-HSA-9664422", "R-HSA-202424", "R-HSA-9664323", "R-HSA-202733", "R-RNO-6798695", "R-RNO-2871796", "R-RNO-2871837"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-202433:r:Generation of second messenger molecules", "R-RNO-5621480:r:Dectin-2 family", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2029481:r:FCGR activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-HSA-164944:r:Nef and signal transduction", "R-BTA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-MMU-5621480:r:Dectin-2 family", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-202433:r:Generation of second messenger molecules", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-389948:r:Co-inhibition by PD-1", "R-BTA-5621480:r:Dectin-2 family", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Family"}, "IPR021664": {"description": "Protein of unknown function DUF3255", "go_ids": [], "go_terms": [], "name": "DUF3255", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021665": {"description": "Mediator complex, subunit Med16, N-terminal", "go_ids": ["GO:0016592"], "go_terms": ["GO:0016592:mediator complex:C"], "name": "Mediator_Med16_N", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR021666": {"description": "Troponin I residues 1-32", "go_ids": [], "go_terms": [], "name": "Troponin-I_N", "pathway_ids": ["R-MMU-390522", "R-HSA-5578775", "R-MMU-5578775", "R-CFA-390522", "R-RNO-390522", "R-HSA-390522", "R-RNO-5578775"], "pathways": ["R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-5578775:r:Ion homeostasis", "R-CFA-390522:r:Striated Muscle Contraction", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-5578775:r:Ion homeostasis"], "type": "Family"}, "IPR021667": {"description": "REDY-like protein HapK", "go_ids": [], "go_terms": [], "name": "HapK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021668": {"description": "Telomere-length maintenance and DNA damage repair", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "TAN", "pathway_ids": ["R-HSA-5685942", "R-MMU-5693571", "R-HSA-5693616", "R-HSA-9704646", "R-HSA-349425", "R-SCE-2559586", "R-MMU-6804756", "R-HSA-5693565", "R-MMU-5693616", "R-HSA-6796648", "R-SPO-9664873", "R-MMU-69541", "R-SPO-6804756", "R-MMU-5685938", "R-MMU-349425", "R-MMU-5693565", "R-MMU-69473", "R-MMU-9664873", "R-SCE-5693565", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-HSA-6804757", "R-HSA-912446", "R-MMU-6803207", "R-SCE-9664873", "R-SCE-5693548", "R-MMU-5693568", "R-MMU-5693579", "R-SPO-6803207", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-MMU-6804760", "R-MMU-5693548", "R-HSA-6803207", "R-HSA-69473", "R-MMU-2559586", "R-MMU-6804757", "R-HSA-9709603", "R-MMU-5685942", "R-SPO-5693565", "R-HSA-6804760", "R-HSA-5693571", "R-MMU-6803204", "R-HSA-6804756", "R-SPO-2559586", "R-HSA-9704331", "R-HSA-6803204", "R-HSA-69541", "R-SPO-5693548", "R-HSA-5693554", "R-HSA-5693548", "R-HSA-5693579", "R-HSA-2559586", "R-HSA-9664873"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-9664873:r:Pexophagy", "R-MMU-69541:r:Stabilization of p53", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-9664873:r:Pexophagy", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-912446:r:Meiotic recombination", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-SCE-9664873:r:Pexophagy", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-69541:r:Stabilization of p53", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9664873:r:Pexophagy"], "type": "Domain"}, "IPR021669": {"description": "Bd37, core domain", "go_ids": [], "go_terms": [], "name": "Bd37_core", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021670": {"description": "Protein of unknown function DUF3256", "go_ids": [], "go_terms": [], "name": "DUF3256", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021671": {"description": "PD(D/E)XK endonuclease", "go_ids": [], "go_terms": [], "name": "PD(D/E)XK_Endonuc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021672": {"description": "Protein of unknown function DUF3258", "go_ids": [], "go_terms": [], "name": "DUF3258", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021673": {"description": "RIG-I-like receptor, C-terminal regulatory domain", "go_ids": [], "go_terms": [], "name": "RLR_CTR", "pathway_ids": ["R-HSA-9833109", "R-MMU-9909505", "R-HSA-8983711", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9920588", "R-HSA-5689896", "R-HSA-5689880", "R-HSA-933542", "R-HSA-936440", "R-HSA-1169408", "R-MMU-1169408", "R-HSA-9909505", "R-MMU-5689880", "R-HSA-918233", "R-HSA-933541", "R-HSA-933543", "R-HSA-9692916", "R-MMU-936440", "R-HSA-9833110", "R-MMU-8983711"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-8983711:r:OAS antiviral response"], "type": "Domain"}, "IPR021674": {"description": "Bacteriophage T4, Gp14, neck protein", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp14_neck-protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021675": {"description": "Protein of unknown function DUF3261", "go_ids": [], "go_terms": [], "name": "DUF3261", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021676": {"description": "Protein of unknown function DUF3262", "go_ids": [], "go_terms": [], "name": "DUF3262", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021677": {"description": "Protein of unknown function DUF2986", "go_ids": [], "go_terms": [], "name": "DUF2986", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021678": {"description": "Protein of unknown function DUF3263", "go_ids": [], "go_terms": [], "name": "DUF3263", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021679": {"description": "Toxin endonuclease, YhaV", "go_ids": ["GO:0004540", "GO:0110001"], "go_terms": ["GO:0004540:RNA nuclease activity:F", "GO:0110001:toxin-antitoxin complex:C"], "name": "Toxin_endonuclease_YhaV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021682": {"description": "Protein of unknown function DUF2933", "go_ids": [], "go_terms": [], "name": "DUF2933", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021683": {"description": "Putative zincin peptidase", "go_ids": [], "go_terms": [], "name": "DUF3267", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021684": {"description": "WW domain-binding protein 1-like", "go_ids": [], "go_terms": [], "name": "WBP1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021685": {"description": "Major surface protein 1a (MSP1a)", "go_ids": [], "go_terms": [], "name": "MSP1a", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021686": {"description": "Protein of unkown function DUF3268", "go_ids": [], "go_terms": [], "name": "DUF3268", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021687": {"description": "Protein of unknown function DUF3269", "go_ids": [], "go_terms": [], "name": "DUF3269", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021688": {"description": "Protein of unknown function DUF3270", "go_ids": [], "go_terms": [], "name": "DUF3270", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021689": {"description": "Protein of unknown function DUF3271", "go_ids": [], "go_terms": [], "name": "DUF3271", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021690": {"description": "Protein of unknown function DUF3272", "go_ids": [], "go_terms": [], "name": "DUF3272", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021691": {"description": "Protein of unknown function DUF3273", "go_ids": [], "go_terms": [], "name": "DUF3273", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021692": {"description": "Antibacterial effector protein Tle3, C-terminal", "go_ids": [], "go_terms": [], "name": "Tle3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021693": {"description": "Protein of unknown function DUF3275", "go_ids": [], "go_terms": [], "name": "DUF3275", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021695": {"description": "Structural protein ORF10, bacteriophage KPP10", "go_ids": [], "go_terms": [], "name": "Phage_KPP10_Orf10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021696": {"description": "Domain of unknown function DUF3279", "go_ids": [], "go_terms": [], "name": "DUF3279", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021697": {"description": "Protein of unknown function DUF3278", "go_ids": [], "go_terms": [], "name": "DUF3278", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021698": {"description": "Protein of unknown function DUF2380", "go_ids": [], "go_terms": [], "name": "DUF3280", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021699": {"description": "Protein of unknown function DUF3281", "go_ids": [], "go_terms": [], "name": "DUF3281", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021700": {"description": "Protein of unknown function DUF3283", "go_ids": [], "go_terms": [], "name": "DUF3283", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021701": {"description": "Protein of unknown function DUF3284", "go_ids": [], "go_terms": [], "name": "DUF3284", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021702": {"description": "Protein of unknown function DUF3285", "go_ids": [], "go_terms": [], "name": "DUF3285", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021704": {"description": "Protein of unknown function DUF3287", "go_ids": [], "go_terms": [], "name": "DUF3287", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021705": {"description": "Protein of unknown function DUF3288", "go_ids": [], "go_terms": [], "name": "DUF3288", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021706": {"description": "Protein of unknown function DUF2990", "go_ids": [], "go_terms": [], "name": "DUF2990", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021707": {"description": "Protein of unknown function DUF3290", "go_ids": [], "go_terms": [], "name": "DUF3290", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021708": {"description": "Domain of unknown function DUF3291", "go_ids": [], "go_terms": [], "name": "DUF3291", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021709": {"description": "Protein of unknown function DUF3292", "go_ids": [], "go_terms": [], "name": "DUF3292", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021710": {"description": "Protein of unknown function DUF3293", "go_ids": [], "go_terms": [], "name": "DUF3293", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021711": {"description": "Domain of unknown function DUF3295", "go_ids": [], "go_terms": [], "name": "DUF3295", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021712": {"description": "Uncharacterised domain UPF0506", "go_ids": [], "go_terms": [], "name": "UPF0506", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021713": {"description": "Folliculin", "go_ids": [], "go_terms": [], "name": "Folliculin", "pathway_ids": ["R-RNO-9639288", "R-MMU-9639288", "R-HSA-9639288", "R-XTR-9639288", "R-BTA-9639288"], "pathways": ["R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-BTA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR021714": {"description": "URB1, N-terminal", "go_ids": [], "go_terms": [], "name": "URB1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021715": {"description": "Pre-mRNA-splicing factor SLU7 domain", "go_ids": [], "go_terms": [], "name": "Slu7_dom", "pathway_ids": ["R-CEL-159236", "R-MMU-72163", "R-HSA-73856", "R-BTA-73856", "R-MMU-73856", "R-RNO-72163", "R-HSA-72187", "R-CEL-73856", "R-DDI-72163", "R-DME-159236", "R-DME-72163", "R-MMU-159236", "R-RNO-73856", "R-DRE-72163", "R-HSA-72163", "R-DRE-159236", "R-DRE-73856", "R-MMU-72187", "R-RNO-159236", "R-BTA-159236", "R-HSA-159236", "R-DME-73856", "R-CEL-72163", "R-BTA-72163"], "pathways": ["R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR021716": {"description": "Thrombin inhibitor Madanin", "go_ids": [], "go_terms": [], "name": "Inhibitor_I53", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021717": {"description": "Nucleoporin Nup120/160", "go_ids": [], "go_terms": [], "name": "Nucleoporin_Nup160", "pathway_ids": ["R-SPO-3371453", "R-HSA-180910", "R-HSA-191859", "R-HSA-2467813", "R-SPO-159227", "R-HSA-3108214", "R-HSA-9705671", "R-SPO-159231", "R-MMU-3232142", "R-MMU-2467813", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-DME-4085377", "R-MMU-68877", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-9615933", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-MMU-4085377", "R-MMU-4551638", "R-HSA-3371453", "R-HSA-68877", "R-HSA-165054", "R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4615885", "R-MMU-9648025", "R-HSA-4551638", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-MMU-2500257", "R-HSA-2500257", "R-DME-3371453", "R-SPO-159236", "R-HSA-168276", "R-HSA-168271", "R-MMU-141444", "R-SPO-4551638", "R-HSA-6784531", "R-DME-4551638", "R-HSA-141444", "R-HSA-4085377", "R-HSA-168325", "R-MMU-3301854", "R-HSA-9648025", "R-DME-159227", "R-HSA-9609690", "R-MMU-170822", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-159230", "R-DME-9615933", "R-HSA-9615933", "R-MMU-159227", "R-SPO-4570464", "R-DME-3301854", "R-HSA-5619107", "R-HSA-5663220", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-MMU-5663220"], "pathways": ["R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-191859:r:snRNP Assembly", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR021718": {"description": "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term", "go_ids": [], "go_terms": [], "name": "CPSF73-100_C", "pathway_ids": ["R-HSA-9770562", "R-DME-77595", "R-MMU-9770562", "R-SPO-159231", "R-SCE-77595", "R-MMU-77595", "R-BTA-73856", "R-MMU-73856", "R-HSA-73856", "R-DDI-9770562", "R-DME-159231", "R-HSA-72187", "R-SPO-77595", "R-HSA-159231", "R-HSA-77595", "R-SPO-9770562", "R-DME-9770562", "R-MMU-72187", "R-DDI-77595", "R-BTA-9770562", "R-BTA-159231", "R-DME-73856", "R-HSA-9918481", "R-MMU-159231", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR021719": {"description": "Proteinase inhibitor I78", "go_ids": [], "go_terms": [], "name": "Prot_inh_I78", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021720": {"description": "Malectin domain", "go_ids": [], "go_terms": [], "name": "Malectin_dom", "pathway_ids": ["R-HSA-532668", "R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR021721": {"description": "Zinc finger, CCCH-type, TRM13", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "Znf_CCCH-type_TRM13", "pathway_ids": ["PWY-6829", "R-HSA-6782315"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR021722": {"description": "YvbH-like, oligomerisation domain", "go_ids": [], "go_terms": [], "name": "YvbH_oligomer_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021724": {"description": "Protein of unknown function DUF3297", "go_ids": [], "go_terms": [], "name": "DUF3297", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021725": {"description": "Pathogenicity locus", "go_ids": [], "go_terms": [], "name": "Cdd1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021726": {"description": "THO complex, subunitTHOC2, N-terminal", "go_ids": [], "go_terms": [], "name": "THO_THOC2_N", "pathway_ids": ["R-MMU-73856", "R-HSA-73856", "R-HSA-159236", "R-HSA-72187", "R-MMU-72187", "R-MMU-159236"], "pathways": ["R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR021727": {"description": "Protein of unknown function DUF3299", "go_ids": [], "go_terms": [], "name": "DUF3299", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021728": {"description": "Protein of unknown function DUF3300", "go_ids": [], "go_terms": [], "name": "DUF3300", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021729": {"description": "Domain of unknown function DUF3298", "go_ids": [], "go_terms": [], "name": "DUF3298", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021730": {"description": "YdbH-like", "go_ids": [], "go_terms": [], "name": "YdbH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021731": {"description": "AMIN domain", "go_ids": [], "go_terms": [], "name": "AMIN_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021732": {"description": "Protein of unknown function DUF3301", "go_ids": [], "go_terms": [], "name": "DUF3301", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021733": {"description": "Protein of unknown function DUF3304", "go_ids": [], "go_terms": [], "name": "DUF3304", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021734": {"description": "Protein of unknown function DUF3303", "go_ids": [], "go_terms": [], "name": "DUF3303", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021735": {"description": "Protein of unknown function DUF3306", "go_ids": [], "go_terms": [], "name": "DUF3306", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021736": {"description": "Protein of unknown function DUF3305", "go_ids": [], "go_terms": [], "name": "DUF3305", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021737": {"description": "Bacteriophage phiKZ, Orf197", "go_ids": [], "go_terms": [], "name": "Phage_phiKZ_Orf197", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021738": {"description": "Protein of unknown function DUF3309", "go_ids": [], "go_terms": [], "name": "DUF3309", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021739": {"description": "SaV-like", "go_ids": [], "go_terms": [], "name": "SaV-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021740": {"description": "Velvet factor", "go_ids": [], "go_terms": [], "name": "Velvet", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021741": {"description": "Protein of unknown function DUF3311", "go_ids": [], "go_terms": [], "name": "DUF3311", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021742": {"description": "Suppressor of RNA silencing P21-like, N-terminal", "go_ids": [], "go_terms": [], "name": "RSS_P20_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021743": {"description": "Keratin-associated protein, type8/19/20/21/22", "go_ids": [], "go_terms": [], "name": "KRTAP_type8/19/20/21/22", "pathway_ids": ["R-MMU-6805567", "R-HSA-6805567"], "pathways": ["R-MMU-6805567:r:Keratinization", "R-HSA-6805567:r:Keratinization"], "type": "Family"}, "IPR021744": {"description": "Cobalamin synthesis G, N-terminal", "go_ids": [], "go_terms": [], "name": "CbiG_N", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Domain"}, "IPR021745": {"description": "Cobalamin biosynthesis central region", "go_ids": [], "go_terms": [], "name": "CbiG_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021746": {"description": "DIPSY domain", "go_ids": [], "go_terms": [], "name": "DIPSY", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021747": {"description": "Protein of unknown function DUF3313", "go_ids": [], "go_terms": [], "name": "DUF3313", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021748": {"description": "Protein of unknown function DUF3314", "go_ids": [], "go_terms": [], "name": "DUF3314", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021749": {"description": "Competence protein ComGE", "go_ids": [], "go_terms": [], "name": "ComGE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021750": {"description": "Septation initiation Sid4-like", "go_ids": [], "go_terms": [], "name": "Sid4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021751": {"description": "Protein of unknown function DUF3318", "go_ids": [], "go_terms": [], "name": "DUF3318", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021752": {"description": "Transcription initiation factor Rrn7, Zinc-finger", "go_ids": [], "go_terms": [], "name": "TF_Rrn7_Zf", "pathway_ids": ["R-BTA-73762", "R-MMU-5250924", "R-MMU-73762", "R-HSA-73772", "R-RNO-73772", "R-DRE-73772", "R-HSA-427413", "R-MMU-73863", "R-RNO-5250924", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762", "R-CEL-73772", "R-DRE-5250924", "R-DRE-73863", "R-HSA-73863", "R-SPO-73772", "R-HSA-427359", "R-HSA-5250924", "R-MMU-73772", "R-BTA-5250924", "R-BTA-73772", "R-DME-73772", "R-SCE-73772", "R-BTA-73863"], "pathways": ["R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73863:r:RNA Polymerase I Transcription Termination"], "type": "Domain"}, "IPR021753": {"description": "Domain of unknown function DUF3319", "go_ids": [], "go_terms": [], "name": "DUF3319", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021754": {"description": "Domain of unknown function DUF3320", "go_ids": [], "go_terms": [], "name": "DUF3320", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021755": {"description": "Transcription factor Aft1, HRA domain", "go_ids": [], "go_terms": [], "name": "TF_Aft1_HRA", "pathway_ids": ["R-SPO-450341", "R-SPO-3214847"], "pathways": ["R-SPO-450341:r:Activation of the AP-1 family of transcription factors", "R-SPO-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR021756": {"description": "Transcription factor Aft1, HRR domain", "go_ids": [], "go_terms": [], "name": "TF_Aft1_HRR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021757": {"description": "Large ribosomal subunit protein mL46, N-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL46_N", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Domain"}, "IPR021758": {"description": "Baculoviridae late expression factor 5, C-terminal", "go_ids": [], "go_terms": [], "name": "Baculo_LEF5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021759": {"description": "WxL Interacting Protein, host binding domain", "go_ids": [], "go_terms": [], "name": "WxLIP_HBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021760": {"description": "Plasmid replication protein C, C-terminal", "go_ids": [], "go_terms": [], "name": "RepC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021761": {"description": "UDP-glucuronate decarboxylase N-terminal", "go_ids": ["GO:0048040"], "go_terms": ["GO:0048040:UDP-glucuronate decarboxylase activity:F"], "name": "UXS1_N", "pathway_ids": ["PWY-4821", "R-XTR-1971475", "R-RNO-1971475", "R-DRE-173599", "R-MMU-173599", "R-HSA-1971475", "R-XTR-173599", "R-HSA-173599", "R-MMU-1971475", "R-RNO-173599", "R-DRE-1971475"], "pathways": ["PWY-4821:t:UDP-alpha-D-xylose biosynthesis", "R-XTR-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DRE-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-XTR-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DRE-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis"], "type": "Domain"}, "IPR021762": {"description": "Protein of unknown function DUF3325", "go_ids": [], "go_terms": [], "name": "DUF3325", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021763": {"description": "Protein of unknown function DUF3326", "go_ids": [], "go_terms": [], "name": "DUF3326", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021764": {"description": "Enterochelin esterase, N-terminal", "go_ids": ["GO:0005506", "GO:0006826", "GO:0008849", "GO:0005737"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0006826:iron ion transport:P", "GO:0008849:enterochelin esterase activity:F", "GO:0005737:cytoplasm:C"], "name": "Enterochelin_esterase_N", "pathway_ids": ["R-HSA-9638334"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin"], "type": "Domain"}, "IPR021765": {"description": "Mycotoxin biosynthesis protein UstYa-like", "go_ids": ["GO:0043386"], "go_terms": ["GO:0043386:mycotoxin biosynthetic process:P"], "name": "UstYa-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021766": {"description": "Phosphate regulon sensor protein PhoR, N-terminal domain", "go_ids": ["GO:0000160", "GO:0004721", "GO:0000155"], "go_terms": ["GO:0000160:phosphorelay signal transduction system:P", "GO:0004721:phosphoprotein phosphatase activity:F", "GO:0000155:phosphorelay sensor kinase activity:F"], "name": "PhoR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021767": {"description": "Transposon Tn21 modulator protein", "go_ids": [], "go_terms": [], "name": "TnpM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021768": {"description": "Protein of unknown function DUF3332", "go_ids": [], "go_terms": [], "name": "DUF3332", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021769": {"description": "Protein of unknown function DUF3331", "go_ids": [], "go_terms": [], "name": "DUF3331", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021770": {"description": "Protein of unknown function DUF3335", "go_ids": [], "go_terms": [], "name": "DUF3335", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021771": {"description": "Triacylglycerol lipase, N-terminal", "go_ids": ["GO:0004806", "GO:0006629"], "go_terms": ["GO:0004806:triacylglycerol lipase activity:F", "GO:0006629:lipid metabolic process:P"], "name": "Triacylglycerol_lipase_N", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Domain"}, "IPR021772": {"description": "WDR48/Bun107, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "WDR48/Bun107_Ubl", "pathway_ids": ["R-GGA-6783310", "R-DME-110314", "R-DRE-5689880", "R-XTR-110314", "R-HSA-9673766", "R-HSA-5689880", "R-GGA-110314", "R-HSA-6783310", "R-MMU-6783310", "R-CEL-5689880", "R-GGA-5689880", "R-MMU-5689880", "R-MMU-110314", "R-DRE-6783310", "R-DRE-110314", "R-XTR-5689880", "R-DDI-5689880", "R-DME-5689880", "R-HSA-110314"], "pathways": ["R-GGA-6783310:r:Fanconi Anemia Pathway", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DRE-5689880:r:Ub-specific processing proteases", "R-XTR-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9673766:r:Signaling by cytosolic PDGFRA and PDGFRB fusion proteins", "R-HSA-5689880:r:Ub-specific processing proteases", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-CEL-5689880:r:Ub-specific processing proteases", "R-GGA-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-DRE-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-XTR-5689880:r:Ub-specific processing proteases", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex"], "type": "Domain"}, "IPR021773": {"description": "Trafficking protein particle complex subunit 11", "go_ids": [], "go_terms": [], "name": "TPC11", "pathway_ids": ["R-HSA-8876198", "R-DRE-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR021774": {"description": "Cytohesin Ubiquitin Protein Inducing Domain", "go_ids": [], "go_terms": [], "name": "CUPID", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021775": {"description": "Protein of unknown function DUF3339", "go_ids": [], "go_terms": [], "name": "DUF3339", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021776": {"description": "Alternative complex III, ActD subunit", "go_ids": [], "go_terms": [], "name": "ActD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021777": {"description": "SANT and BTB domain regulator of CSR, BTB domain", "go_ids": [], "go_terms": [], "name": "SANBR_BTB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021778": {"description": "Putative Se/S carrier protein-like", "go_ids": [], "go_terms": [], "name": "Se/S_carrier-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021779": {"description": "Domain of unknown function DUF3344", "go_ids": [], "go_terms": [], "name": "DUF3344", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021780": {"description": "Nuclear/hormone receptor activator site AF-1", "go_ids": [], "go_terms": [], "name": "Nuc_recep-AF1", "pathway_ids": ["R-HSA-1989781", "R-RNO-193807", "R-DRE-211976", "R-DRE-193807", "R-DRE-192105", "R-HSA-2151201", "R-BTA-5362517", "R-DRE-400206", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-159418", "R-HSA-9844594", "R-SSC-383280", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-4090294", "R-HSA-9616222", "R-RNO-4090294", "R-RNO-383280", "R-DRE-381340", "R-DRE-200425", "R-MMU-200425", "R-MMU-192105", "R-HSA-192105", "R-DRE-5362517", "R-DRE-9841922", "R-HSA-193807", "R-DRE-159418", "R-MMU-381340", "R-MMU-211976", "R-RNO-381340", "R-RNO-193368", "R-HSA-400206", "R-RNO-211976", "R-RNO-9841922", "R-DRE-9707564", "R-MMU-9616222", "R-DRE-383280", "R-RNO-9616222", "R-HSA-211976", "R-MMU-400206", "R-HSA-5617472", "R-HSA-9623433", "R-MMU-193807", "R-RNO-5362517", "R-HSA-9029558", "R-DRE-193368", "R-HSA-193368", "R-DRE-9616222", "R-RNO-9029569", "R-DRE-9623433", "R-DRE-9029569", "R-RNO-192105", "R-MMU-383280", "R-RNO-159418", "R-RNO-200425", "R-MMU-9841922", "R-MMU-4090294", "R-HSA-9029569", "R-HSA-5362517", "R-MMU-9029569", "R-HSA-9931509", "R-RNO-400206", "R-HSA-9839394", "R-MMU-193368", "R-MMU-9623433", "R-HSA-9031525", "R-HSA-381340", "R-HSA-9632974", "R-HSA-9707616", "R-RNO-9707564", "R-RNO-9623433", "R-HSA-383280", "R-BTA-383280", "R-DRE-4090294", "R-HSA-200425", "R-MMU-5362517", "R-HSA-159418", "R-HSA-9031528", "R-HSA-2426168", "R-MMU-9707564"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DRE-211976:r:Endogenous sterols", "R-DRE-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DRE-192105:r:Synthesis of bile acids and bile salts", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-BTA-5362517:r:Signaling by Retinoic Acid", "R-DRE-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-159418:r:Recycling of bile acids and salts", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-SSC-383280:r:Nuclear Receptor transcription pathway", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-DRE-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-DRE-200425:r:Carnitine shuttle", "R-MMU-200425:r:Carnitine shuttle", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-DRE-5362517:r:Signaling by Retinoic Acid", "R-DRE-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DRE-159418:r:Recycling of bile acids and salts", "R-MMU-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-211976:r:Endogenous sterols", "R-RNO-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-211976:r:Endogenous sterols", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-MMU-9616222:r:Transcriptional regulation of granulopoiesis", "R-DRE-383280:r:Nuclear Receptor transcription pathway", "R-RNO-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-211976:r:Endogenous sterols", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-RNO-5362517:r:Signaling by Retinoic Acid", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DRE-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DRE-9616222:r:Transcriptional regulation of granulopoiesis", "R-RNO-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DRE-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-DRE-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-200425:r:Carnitine shuttle", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9839394:r:TGFBR3 expression", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-HSA-9707616:r:Heme signaling", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-RNO-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-BTA-383280:r:Nuclear Receptor transcription pathway", "R-DRE-4090294:r:SUMOylation of intracellular receptors", "R-HSA-200425:r:Carnitine shuttle", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9031528:r:NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR021781": {"description": "Replication initiator protein RctB, central region", "go_ids": [], "go_terms": [], "name": "RctB_central_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021782": {"description": "Domain of unknown function DUF3347", "go_ids": [], "go_terms": [], "name": "DUF3347", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021783": {"description": "Protein of unknown function DUF3348", "go_ids": [], "go_terms": [], "name": "DUF3348", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021784": {"description": "Protein of unknown function DUF3349", "go_ids": [], "go_terms": [], "name": "DUF3349", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021785": {"description": "Domain of unknown function DUF3350", "go_ids": [], "go_terms": [], "name": "DUF3350", "pathway_ids": ["R-HSA-1445148"], "pathways": ["R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "type": "Domain"}, "IPR021786": {"description": "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal", "go_ids": [], "go_terms": [], "name": "Cdc5p/Cef1_C", "pathway_ids": ["R-HSA-72163", "R-RNO-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR021787": {"description": "Protein of unknown function DUF3352", "go_ids": [], "go_terms": [], "name": "DUF3352", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021788": {"description": "Protein CHAPERONE-LIKE PROTEIN OF POR1-like", "go_ids": [], "go_terms": [], "name": "CPP1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021789": {"description": "KHA domain", "go_ids": [], "go_terms": [], "name": "KHA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021790": {"description": "PTBP1-like, RNA recognition motif 2", "go_ids": [], "go_terms": [], "name": "PTBP1-like_RRM2", "pathway_ids": ["R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-RNO-72203", "R-MMU-9770562", "R-MMU-72163", "R-SSC-72163", "R-HSA-6803529", "R-RNO-72163", "R-SSC-72203", "R-HSA-72163", "R-BTA-6803529", "R-RNO-9770562", "R-BTA-9770562", "R-SSC-6803529", "R-SSC-9770562", "R-BTA-72203", "R-HSA-9918481", "R-RNO-6803529", "R-MMU-6803529", "R-BTA-72163"], "pathways": ["R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SSC-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-SSC-6803529:r:FGFR2 alternative splicing", "R-SSC-9770562:r:mRNA Polyadenylation", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR021791": {"description": "Phage tail tube protein, GTA-gp10", "go_ids": [], "go_terms": [], "name": "Phage_TAC_11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021792": {"description": "Beta-fructofuranosidase, N-terminal domain", "go_ids": ["GO:0004564"], "go_terms": ["GO:0004564:beta-fructofuranosidase activity:F"], "name": "Beta-fructofuranosidase_N", "pathway_ids": ["PWY-8314"], "pathways": ["PWY-8314:t:inulin degradation"], "type": "Domain"}, "IPR021793": {"description": "Major outer membrane lipoprotein Oprl", "go_ids": [], "go_terms": [], "name": "Oprl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021794": {"description": "Protein of unknown function DUF3360", "go_ids": [], "go_terms": [], "name": "DUF3360", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021795": {"description": "Protein of unknown function DUF3363", "go_ids": [], "go_terms": [], "name": "DUF3363", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021796": {"description": "Tll0287-like domain", "go_ids": [], "go_terms": [], "name": "Tll0287-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021797": {"description": "Virulence factor membrane-bound polymerase, C-terminal", "go_ids": [], "go_terms": [], "name": "Wzy_C_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021798": {"description": "Alpha-(1->3)-arabinofuranosyltransferase, N-terminal GT-C domain", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "AftD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021799": {"description": "PIN-like domain, prokaryotic", "go_ids": [], "go_terms": [], "name": "PIN-like_prokaryotic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021800": {"description": "3'3'-cGAMP-specific phosphodiesterase 2, middle domain", "go_ids": [], "go_terms": [], "name": "CGAP2_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021801": {"description": "Protein of unknown function DUF3370", "go_ids": [], "go_terms": [], "name": "DUF3370", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021802": {"description": "MiT/TFE transcription factors, C-terminal", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "MiT/TFE_C", "pathway_ids": ["R-MMU-9856649", "R-HSA-9825895", "R-MMU-9824594", "R-HSA-9931510", "R-HSA-9854907", "R-RNO-3232118", "R-HSA-9854909", "R-RNO-9856649", "R-HSA-9926550", "R-HSA-3232118", "R-MMU-3232118", "R-HSA-9857377", "R-HSA-9856649", "R-RNO-9824594", "R-HSA-9824594", "R-HSA-9825892", "R-HSA-9824585"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-MMU-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9854907:r:Regulation of MITF-M dependent genes involved in metabolism", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation"], "type": "Domain"}, "IPR021803": {"description": "Protein of unknown function DUF3373", "go_ids": [], "go_terms": [], "name": "DUF3373", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021804": {"description": "Protein of unknown function DUF3375", "go_ids": [], "go_terms": [], "name": "DUF3375", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021805": {"description": "Peptidase M10A, matrix metallopeptidase, C-terminal", "go_ids": ["GO:0004222"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F"], "name": "Pept_M10A_metallopeptidase_C", "pathway_ids": ["R-HSA-1474228", "R-MMU-9839383", "R-RNO-1592389", "R-MMU-1592389", "R-RNO-1442490", "R-RNO-1474228", "R-RNO-9839383", "R-HSA-9839383", "R-HSA-1592389", "R-HSA-9856530", "R-MMU-1442490", "R-HSA-1442490", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1442490:r:Collagen degradation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-1442490:r:Collagen degradation", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR021806": {"description": "Protein of unknown function DUF3379", "go_ids": [], "go_terms": [], "name": "DUF3379", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021807": {"description": "High-affinity branched-chain amino acid transport system permease, LivHM, N-terminal", "go_ids": [], "go_terms": [], "name": "LivHM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021808": {"description": "E217 tail sheath protein gp31-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "E217_gp31-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021809": {"description": "Protein of unknown function DUF3386", "go_ids": [], "go_terms": [], "name": "DUF3386", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021810": {"description": "Type I restriction enzyme HindI endonuclease subunit-like, C-terminal", "go_ids": [], "go_terms": [], "name": "T1RH-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021811": {"description": "Protein of unknown function DUF3389", "go_ids": [], "go_terms": [], "name": "DUF3389", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021812": {"description": "Domain of unknown function DUF3391", "go_ids": [], "go_terms": [], "name": "DUF3391", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021813": {"description": "Protein of unknown function DUF3392", "go_ids": [], "go_terms": [], "name": "DUF3392", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021814": {"description": "Protein of unknown function DUF3394", "go_ids": [], "go_terms": [], "name": "DUF3394", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021815": {"description": "Type VI immunity for VRR-NUC", "go_ids": [], "go_terms": [], "name": "TsiV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021816": {"description": "Dedicator of cytokinesis C/D, N-terminal", "go_ids": [], "go_terms": [], "name": "DOCK_C/D_N", "pathway_ids": ["R-HSA-9013409", "R-HSA-8875555", "R-HSA-983231", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-983231", "R-HSA-9013404", "R-DRE-983231", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-MMU-8875555", "R-HSA-9013423", "R-HSA-9013148", "R-DRE-9013149", "R-MMU-9013149"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR021817": {"description": "Protein of unknown function DUF3400", "go_ids": [], "go_terms": [], "name": "DUF3400", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021818": {"description": "Signal-induced proliferation-associated 1-like protein, C-terminal", "go_ids": [], "go_terms": [], "name": "SIPA1L_C", "pathway_ids": ["R-HSA-6794361"], "pathways": ["R-HSA-6794361:r:Neurexins and neuroligins"], "type": "Domain"}, "IPR021819": {"description": "Far11/STRP, C-terminal", "go_ids": [], "go_terms": [], "name": "Far11/STRP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021820": {"description": "S-locus receptor kinase, C-terminal", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "S-locus_recpt_kinase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021821": {"description": "Histidine kinase VxrA, sensor domain", "go_ids": [], "go_terms": [], "name": "VxrA_SD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021822": {"description": "Protein of unknown function DUF3405", "go_ids": [], "go_terms": [], "name": "DUF3405", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021823": {"description": "Protein of unknown function DUF3408", "go_ids": [], "go_terms": [], "name": "DUF3408", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021824": {"description": "Capsid protein C, pestivirus", "go_ids": ["GO:0004197", "GO:0017111", "GO:0016817", "GO:0003968", "GO:0070008", "GO:0004252"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0017111:ribonucleoside triphosphate phosphatase activity:F", "GO:0016817:hydrolase activity, acting on acid anhydrides:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0070008:serine-type exopeptidase activity:F", "GO:0004252:serine-type endopeptidase activity:F"], "name": "Capsid-C_pestivirus", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR021825": {"description": "Protein RETICULATA-related", "go_ids": [], "go_terms": [], "name": "RETICULATA-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021826": {"description": "Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PpnN_C", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7570", "PWY-2681", "PWY-5316", "PWY-6617", "PWY-7564", "PWY-8106", "PWY-7569"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7570:t:blasticidin S biosynthesis", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-6617:t:adenosine nucleotides degradation III", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7569:t:arginomycin biosynthesis"], "type": "Domain"}, "IPR021827": {"description": "Nucleoporin Nup186/Nup192/Nup205", "go_ids": ["GO:0005643"], "go_terms": ["GO:0005643:nuclear pore:C"], "name": "Nup186/Nup192/Nup205", "pathway_ids": ["R-SPO-3371453", "R-HSA-180910", "R-HSA-9705671", "R-HSA-3108214", "R-SPO-159227", "R-HSA-191859", "R-SPO-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-DME-4085377", "R-HSA-170822", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-168333", "R-HSA-3371453", "R-HSA-165054", "R-DME-4615885", "R-HSA-4570464", "R-SPO-4085377", "R-HSA-4615885", "R-HSA-4551638", "R-DME-3108214", "R-HSA-9610379", "R-DME-3371453", "R-SPO-159236", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-DME-4551638", "R-HSA-6784531", "R-DME-159227", "R-HSA-4085377", "R-HSA-168325", "R-HSA-9609690", "R-HSA-159231", "R-DME-159230", "R-DME-9615933", "R-HSA-3232142", "R-HSA-3301854", "R-DME-3301854", "R-HSA-9615933", "R-SPO-4570464", "R-HSA-5619107", "R-HSA-159236", "R-HSA-180746"], "pathways": ["R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-191859:r:snRNP Assembly", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Family"}, "IPR021828": {"description": "Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S", "go_ids": ["GO:0004553"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "GlgE_dom_N/S", "pathway_ids": ["PWY-7900"], "pathways": ["PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)"], "type": "Domain"}, "IPR021829": {"description": "Protein of unknown function DUF3419", "go_ids": [], "go_terms": [], "name": "DUF3419", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021830": {"description": "Protein of unknown function DUF3422", "go_ids": [], "go_terms": [], "name": "DUF3422", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021831": {"description": "ParD-like antitoxin of type II bacterial toxin-antitoxin system", "go_ids": [], "go_terms": [], "name": "ParD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021832": {"description": "Ankyrin repeat domain-containing protein 13", "go_ids": [], "go_terms": [], "name": "ANKRD13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021833": {"description": "Protein of unknown function DUF3425", "go_ids": [], "go_terms": [], "name": "DUF3425", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021834": {"description": "Domain of unknown function DUF3426", "go_ids": [], "go_terms": [], "name": "DUF3426", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021835": {"description": "Domain of unknown function DUF3427", "go_ids": [], "go_terms": [], "name": "DUF3427", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021836": {"description": "Protein of unknown function DUF3429", "go_ids": [], "go_terms": [], "name": "DUF3429", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021837": {"description": "Counting factor-associated protein A/B/C", "go_ids": [], "go_terms": [], "name": "CfaA/B/C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021838": {"description": "Protein of unknown function DUF3431", "go_ids": [], "go_terms": [], "name": "DUF3431", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021839": {"description": "Early growth response protein 1, C-terminal", "go_ids": [], "go_terms": [], "name": "EGR1_C", "pathway_ids": ["R-HSA-909733", "R-HSA-8943724", "R-HSA-9031628"], "pathways": ["R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9031628:r:NGF-stimulated transcription"], "type": "Repeat"}, "IPR021840": {"description": "Protein of unknown function DUF3433", "go_ids": [], "go_terms": [], "name": "DUF3433", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021841": {"description": "Vacuolar protein 14, C-terminal Fig4-binding domain", "go_ids": [], "go_terms": [], "name": "VAC14_Fig4p-bd", "pathway_ids": ["R-HSA-1660517", "R-RNO-1660517", "R-MMU-1660517", "R-RNO-1660516", "R-MMU-1660516", "R-MMU-1660514", "R-HSA-1660514", "R-RNO-1660514", "R-HSA-1660516"], "pathways": ["R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane"], "type": "Domain"}, "IPR021842": {"description": "Protein of unknown function DUF3435", "go_ids": [], "go_terms": [], "name": "DUF3435", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021843": {"description": "Proteasome activator complex subunit 4, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PSME4_C", "pathway_ids": ["R-HSA-9907900"], "pathways": ["R-HSA-9907900:r:Proteasome assembly"], "type": "Domain"}, "IPR021844": {"description": "Integrating conjugative element protein, PFL4704", "go_ids": [], "go_terms": [], "name": "Integr_conj_element_PFL4704", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021845": {"description": "Protein of unknown function DUF3440", "go_ids": [], "go_terms": [], "name": "DUF3440", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021846": {"description": "NFACT protein, C-terminal", "go_ids": [], "go_terms": [], "name": "NFACT-C", "pathway_ids": ["R-SPO-9954709", "R-SCE-9954709", "R-DME-9954709", "R-HSA-9954709", "R-MMU-9954709"], "pathways": ["R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR021847": {"description": "Protein of unknown function DUF3443", "go_ids": [], "go_terms": [], "name": "DUF3443", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021848": {"description": "Haem-dependent oxidative N-demethylase, alpha subunit-like", "go_ids": [], "go_terms": [], "name": "HODM_asu-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021849": {"description": "Early growth response, N-terminal", "go_ids": [], "go_terms": [], "name": "EGR_N", "pathway_ids": ["R-RNO-9031628", "R-SSC-9031628", "R-HSA-909733", "R-HSA-8943724", "R-HSA-381340", "R-HSA-9619665", "R-HSA-9031628", "R-MMU-9031628", "R-HSA-5617472", "R-DRE-9031628"], "pathways": ["R-RNO-9031628:r:NGF-stimulated transcription", "R-SSC-9031628:r:NGF-stimulated transcription", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9031628:r:NGF-stimulated transcription", "R-MMU-9031628:r:NGF-stimulated transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-DRE-9031628:r:NGF-stimulated transcription"], "type": "Domain"}, "IPR021850": {"description": "Symplekin/Pta1", "go_ids": [], "go_terms": [], "name": "Symplekin/Pta1", "pathway_ids": ["R-HSA-9770562", "R-DME-77595", "R-MMU-9770562", "R-SPO-159231", "R-SCE-77595", "R-MMU-77595", "R-MMU-73856", "R-DME-159231", "R-HSA-73856", "R-HSA-72187", "R-SPO-77595", "R-HSA-159231", "R-DME-9770562", "R-SPO-9770562", "R-HSA-77595", "R-MMU-72187", "R-DME-73856", "R-HSA-9918481", "R-MMU-159231"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript"], "type": "Family"}, "IPR021851": {"description": "Protein of unknown function DUF3455", "go_ids": [], "go_terms": [], "name": "DUF3455", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021852": {"description": "Domain of unknown function DUF3456", "go_ids": [], "go_terms": [], "name": "DUF3456", "pathway_ids": ["R-HSA-1679131", "R-BTA-1679131", "R-MMU-1679131", "R-SSC-1679131"], "pathways": ["R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-BTA-1679131:r:Trafficking and processing of endosomal TLR", "R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-SSC-1679131:r:Trafficking and processing of endosomal TLR"], "type": "Domain"}, "IPR021853": {"description": "Protein of unknown function DUF3460", "go_ids": [], "go_terms": [], "name": "DUF3460", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021854": {"description": "WASH1, WAHD domain", "go_ids": [], "go_terms": [], "name": "WASH1_WAHD", "pathway_ids": ["R-DME-5663213", "R-DME-2029482", "R-CEL-2029482", "R-CEL-5663213"], "pathways": ["R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs"], "type": "Domain"}, "IPR021855": {"description": "PAM68-like", "go_ids": [], "go_terms": [], "name": "PAM68-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021856": {"description": "Protein of unknown function DUF3465", "go_ids": [], "go_terms": [], "name": "DUF3465", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021857": {"description": "Protein of unknown function DUF3467", "go_ids": [], "go_terms": [], "name": "DUF3467", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021858": {"description": "Fungal transcription factor", "go_ids": [], "go_terms": [], "name": "Fun_TF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021859": {"description": "XRN2-binding (XTBD) domain", "go_ids": [], "go_terms": [], "name": "XTBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021860": {"description": "Peptidase S12, Pab87-related, C-terminal", "go_ids": [], "go_terms": [], "name": "Peptidase_S12_Pab87-rel_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021861": {"description": "THO complex, subunit THOC1", "go_ids": [], "go_terms": [], "name": "THO_THOC1", "pathway_ids": ["R-DRE-159236", "R-MMU-73856", "R-HSA-73856", "R-HSA-159236", "R-HSA-72187", "R-DRE-73856", "R-MMU-72187", "R-MMU-159236"], "pathways": ["R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR021862": {"description": "Surface attachment protein BPSS1860", "go_ids": [], "go_terms": [], "name": "BPSS1860", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021863": {"description": "Fatty acid desaturase, N-terminal", "go_ids": ["GO:0016717"], "go_terms": ["GO:0016717:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water:F"], "name": "FAS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021864": {"description": "Domain of unknown function DUF3475", "go_ids": ["GO:0045927"], "go_terms": ["GO:0045927:positive regulation of growth:P"], "name": "DUF3475", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021865": {"description": "Peptidase G2, IMC autoproteolytic cleavage domain", "go_ids": [], "go_terms": [], "name": "Peptidase_G2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021866": {"description": "SpoIIAA-like", "go_ids": [], "go_terms": [], "name": "SpoIIAA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021867": {"description": "S-adenosylmethionine-dependent methyltransferase Bmt2-like", "go_ids": [], "go_terms": [], "name": "Bmt2/SAMTOR", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-GGA-9639288", "R-MMU-9639288", "R-HSA-9639288"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-GGA-9639288:r:Amino acids regulate mTORC1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR021868": {"description": "Alpha-2-macroglobulin, MG3 domain", "go_ids": [], "go_terms": [], "name": "Alpha_2_Macroglob_MG3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021869": {"description": "Ribonuclease Zc3h12a-like, NYN domain", "go_ids": [], "go_terms": [], "name": "RNase_Zc3h12_NYN", "pathway_ids": ["R-HSA-9758274", "R-MMU-9758274", "R-HSA-9764302", "R-DRE-9758274", "R-XTR-9758274"], "pathways": ["R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-DRE-9758274:r:Regulation of NF-kappa B signaling", "R-XTR-9758274:r:Regulation of NF-kappa B signaling"], "type": "Domain"}, "IPR021870": {"description": "Major vault protein, shoulder domain", "go_ids": [], "go_terms": [], "name": "MVP_shoulder", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR021871": {"description": "Protein of unknown function DUF3482", "go_ids": [], "go_terms": [], "name": "DUF3482", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021872": {"description": "Csal_0991-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Csal_0991-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021873": {"description": "Cell division protein FtsA, C-terminal", "go_ids": [], "go_terms": [], "name": "FtsA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021874": {"description": "Bacteriophage Mu, Gp27", "go_ids": [], "go_terms": [], "name": "Phage_Mu_Gp27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021875": {"description": "Retrograde transport protein Dsl1 N-terminal domain", "go_ids": [], "go_terms": [], "name": "Dsl1_N_dom", "pathway_ids": ["R-SCE-6811434"], "pathways": ["R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR021876": {"description": "Retrograde transport protein Dsl1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Dsl1_C", "pathway_ids": ["R-SCE-6811434"], "pathways": ["R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR021877": {"description": "Protein of unknown function DUF3487", "go_ids": [], "go_terms": [], "name": "DUF3487", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021878": {"description": "Protein-glutamine gamma-glutamyltransferase TgpA, N-terminal", "go_ids": [], "go_terms": [], "name": "TgpA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021879": {"description": "VC2046 family", "go_ids": [], "go_terms": [], "name": "VC2046_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021880": {"description": "Protein of unknown function DUF3489", "go_ids": [], "go_terms": [], "name": "DUF3489", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021881": {"description": "NPK1-activating kinesin-like protein, C-terminal", "go_ids": [], "go_terms": [], "name": "NACK_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021882": {"description": "Domain of unknown function DUF3491", "go_ids": [], "go_terms": [], "name": "DUF3491", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021883": {"description": "Protein LOW PSII ACCUMULATION 1-like", "go_ids": [], "go_terms": [], "name": "LPA1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021884": {"description": "Ice-binding protein", "go_ids": [], "go_terms": [], "name": "Ice-bd_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021885": {"description": "Domain of unknown function DUF3496", "go_ids": [], "go_terms": [], "name": "DUF3496", "pathway_ids": ["R-MMU-9696264", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9696270", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR021886": {"description": "MgsA AAA+ ATPase, C-terminal", "go_ids": [], "go_terms": [], "name": "MgsA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021887": {"description": "Disabled homolog 2-interacting protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DAB2P_C", "pathway_ids": ["R-DME-5658442", "R-MMU-5658442", "R-HSA-5658442", "R-RNO-5658442", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-DME-5658442:r:Regulation of RAS by GAPs", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR021888": {"description": "Protein of unknown function DUF3499", "go_ids": [], "go_terms": [], "name": "DUF3499", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021889": {"description": "Protein of unknown function DUF3500", "go_ids": [], "go_terms": [], "name": "DUF3500", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021890": {"description": "Protein of unknown function DUF3501", "go_ids": [], "go_terms": [], "name": "DUF3501", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021891": {"description": "Telomerase ribonucleoprotein complex - RNA-binding domain", "go_ids": ["GO:0003964"], "go_terms": ["GO:0003964:RNA-directed DNA polymerase activity:F"], "name": "Telomerase_RBD", "pathway_ids": ["R-MMU-201722", "R-HSA-201722", "R-HSA-9825895", "R-RNO-201722", "R-RNO-171319", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR021892": {"description": "RNA helicase NPH-II", "go_ids": ["GO:0017111"], "go_terms": ["GO:0017111:ribonucleoside triphosphate phosphatase activity:F"], "name": "NPH-II", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021893": {"description": "ZMYM2-like/QRICH1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ZMYM2-like_C", "pathway_ids": ["R-HSA-9703465", "R-HSA-9764725", "R-HSA-5655302", "R-MMU-9764725", "R-HSA-1839117"], "pathways": ["R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR021895": {"description": "Bud3, N-terminal", "go_ids": [], "go_terms": [], "name": "Bud3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021896": {"description": "THAP9-like, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "THAP9-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021897": {"description": "Cilia- and flagella-associated protein 206", "go_ids": [], "go_terms": [], "name": "FAP206", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021898": {"description": "Protein of unknown function DUF3509", "go_ids": [], "go_terms": [], "name": "DUF3509", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021899": {"description": "Protein of unknown function DUF3511", "go_ids": [], "go_terms": [], "name": "DUF3511", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021900": {"description": "Protein of unknown function DUF3512", "go_ids": [], "go_terms": [], "name": "DUF3512", "pathway_ids": ["R-HSA-9933947", "R-MMU-9933939", "R-HSA-9933939", "R-XTR-9933947", "R-HSA-6804758", "R-MMU-9933947", "R-MMU-6804758", "R-DRE-9933947"], "pathways": ["R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-XTR-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-9933947:r:Formation of the non-canonical BAF (ncBAF) complex"], "type": "Family"}, "IPR021901": {"description": "CAS family, C-terminal", "go_ids": [], "go_terms": [], "name": "CAS_C", "pathway_ids": ["R-MMU-372708", "R-RNO-186763", "R-RNO-8849471", "R-HSA-186763", "R-RNO-372708", "R-HSA-372708", "R-MMU-4420097", "R-MMU-8849471", "R-MMU-186763", "R-RNO-4420097", "R-HSA-8849471", "R-HSA-4420097"], "pathways": ["R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-186763:r:Downstream signal transduction", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-186763:r:Downstream signal transduction", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR021902": {"description": "Protein of unknown function DUF3514", "go_ids": [], "go_terms": [], "name": "DUF3514", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021903": {"description": "Protein of unknown function DUF3515", "go_ids": [], "go_terms": [], "name": "DUF3515", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021904": {"description": "Protein of unknown function DUF3516", "go_ids": [], "go_terms": [], "name": "DUF3516", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021905": {"description": "Ubiquitin C-terminal hydrolase-like, DUF3517", "go_ids": [], "go_terms": [], "name": "DUF3517", "pathway_ids": ["R-MMU-2173795", "R-HSA-201681", "R-HSA-9013420", "R-DME-9033241", "R-HSA-5689880", "R-HSA-977225", "R-MMU-9013424", "R-DME-9758274", "R-MMU-201681", "R-DME-2173795", "R-DME-9013424", "R-MMU-8866652", "R-MMU-9033241", "R-HSA-9013424", "R-DME-8866652", "R-MMU-5689880", "R-DME-445989", "R-MMU-9013420", "R-HSA-8866652", "R-HSA-2173795", "R-HSA-9033241", "R-DME-5689880", "R-DME-9013420"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DME-9033241:r:Peroxisomal protein import", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR021906": {"description": "SWI/SNF-like complex subunit BAF250/Osa", "go_ids": ["GO:0016514", "GO:0035060", "GO:0006338"], "go_terms": ["GO:0016514:SWI/SNF complex:C", "GO:0035060:brahma complex:C", "GO:0006338:chromatin remodeling:P"], "name": "BAF250/Osa", "pathway_ids": ["R-DME-8939243", "R-DME-9933946", "R-MMU-9933946", "R-MMU-9934037", "R-MMU-9933937", "R-DME-9934037", "R-HSA-9764790", "R-HSA-3214858", "R-HSA-9934037", "R-HSA-9824585", "R-MMU-3214858", "R-MMU-8939243", "R-HSA-8939243", "R-DME-3214858", "R-HSA-9845323", "R-HSA-9933937", "R-DME-9933937", "R-HSA-9933946"], "pathways": ["R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-3214858:r:RMTs methylate histone arginines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex"], "type": "Family"}, "IPR021907": {"description": "Protein of unknown function DUF3519", "go_ids": [], "go_terms": [], "name": "DUF3519", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021908": {"description": "Uncharacterized protein YfbK, C-terminal", "go_ids": [], "go_terms": [], "name": "YfbK_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021910": {"description": "NGX6/PGAP6/MYMK", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "NGX6/PGAP6/MYMK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021911": {"description": "ATPase family AAA domain-containing protein 3, N-terminal", "go_ids": [], "go_terms": [], "name": "ATAD3_N", "pathway_ids": ["R-HSA-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-DME-6798695", "R-XTR-6798695", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR021912": {"description": "Protein of unknown function DUF3525", "go_ids": [], "go_terms": [], "name": "DUF3525", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021913": {"description": "Protein of unknown function DUF3526", "go_ids": [], "go_terms": [], "name": "DUF3526", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021914": {"description": "Transcriptional factor DELLA, N-terminal", "go_ids": [], "go_terms": [], "name": "TF_DELLA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021915": {"description": "Tubuliform egg casing silk strands structural domain", "go_ids": [], "go_terms": [], "name": "RP1-2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021916": {"description": "Protein of unknown function DUF3527", "go_ids": [], "go_terms": [], "name": "DUF3527", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021917": {"description": "Uncharacterised protein family, zinc metallopeptidase-like", "go_ids": [], "go_terms": [], "name": "Unchr_Zn-peptidase-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021918": {"description": "Domain of unknown function DUF3528, homeobox protein, eukaryotic", "go_ids": [], "go_terms": [], "name": "DUF3528", "pathway_ids": ["R-HSA-9830674"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud"], "type": "Domain"}, "IPR021919": {"description": "Cofactor assembly of complex C subunit B, CCB1", "go_ids": [], "go_terms": [], "name": "CCB1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021920": {"description": "Protein of unknown function DUF3531", "go_ids": [], "go_terms": [], "name": "DUF3531", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021922": {"description": "Par3/HAL, N-terminal", "go_ids": [], "go_terms": [], "name": "Par3/HAL_N", "pathway_ids": ["R-MMU-420029", "R-RNO-70921", "R-HSA-2173791", "R-HSA-420029", "R-MMU-70921", "R-MMU-2173791", "R-CEL-70921", "R-RNO-420029", "R-RNO-2173791"], "pathways": ["R-MMU-420029:r:Tight junction interactions", "R-RNO-70921:r:Histidine catabolism", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-420029:r:Tight junction interactions", "R-MMU-70921:r:Histidine catabolism", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-70921:r:Histidine catabolism", "R-RNO-420029:r:Tight junction interactions", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "type": "Domain"}, "IPR021923": {"description": "Protein of unknown function DUF3536", "go_ids": [], "go_terms": [], "name": "DUF3536", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021924": {"description": "Protein of unknown function DUF3537", "go_ids": [], "go_terms": [], "name": "DUF3537", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021925": {"description": "Large proline-rich protein BAG6", "go_ids": [], "go_terms": [], "name": "BAG6", "pathway_ids": ["R-HSA-9609523"], "pathways": ["R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Domain"}, "IPR021926": {"description": "PII-interacting protein X, cyanobacteria", "go_ids": [], "go_terms": [], "name": "PipX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021927": {"description": "Protein of unknown function DUF3540", "go_ids": [], "go_terms": [], "name": "DUF3540", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021928": {"description": "Protein of unknown function DUF3541", "go_ids": [], "go_terms": [], "name": "DUF3541", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021929": {"description": "Late blight resistance protein R1A-like, N-terminal", "go_ids": [], "go_terms": [], "name": "R1A-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021930": {"description": "Heparan sulphate-N-deacetylase, deacetylase domain", "go_ids": ["GO:0015016", "GO:0016787"], "go_terms": ["GO:0015016:heparan sulfate N-sulfotransferase activity:F", "GO:0016787:hydrolase activity:F"], "name": "Heparan_SO4_deacetylase_dom", "pathway_ids": ["PWY-6558", "R-MMU-2022928", "R-HSA-2022928", "R-CEL-2022928", "R-DME-2022928", "R-RNO-2022928"], "pathways": ["PWY-6558:t:heparan sulfate biosynthesis", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-DME-2022928:r:HS-GAG biosynthesis", "R-RNO-2022928:r:HS-GAG biosynthesis"], "type": "Domain"}, "IPR021931": {"description": "MYND-type zinc finger-containing chromatin reader ZMYND8", "go_ids": [], "go_terms": [], "name": "ZMYND8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021932": {"description": "Protein of unknown function DUF3545", "go_ids": [], "go_terms": [], "name": "DUF3545", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021933": {"description": "SERRATE/Ars2, N-terminal", "go_ids": [], "go_terms": [], "name": "SERRATE/Ars2_N", "pathway_ids": ["R-MMU-9930044", "R-CEL-6807505", "R-HSA-9930044", "R-HSA-6807505", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-DME-72163", "R-SPO-9930044", "R-DME-9930044", "R-MMU-6807505", "R-DRE-6807505", "R-BTA-9930044", "R-DRE-9930044", "R-DRE-72163", "R-SPO-9770562", "R-HSA-72163", "R-DME-9770562", "R-DME-6807505", "R-DRE-9770562", "R-CEL-9770562", "R-BTA-9770562", "R-CEL-9930044", "R-CEL-72163", "R-BTA-6807505", "R-SPO-72163", "R-HSA-9918481", "R-BTA-72163"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9930044:r:Nuclear RNA decay", "R-DME-9930044:r:Nuclear RNA decay", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-9930044:r:Nuclear RNA decay", "R-DRE-9930044:r:Nuclear RNA decay", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR021935": {"description": "Small G protein signalling modulator 1/2, Rab-binding domain", "go_ids": [], "go_terms": [], "name": "SGSM1/2_RBD", "pathway_ids": ["R-HSA-8854214", "R-MMU-8854214", "R-SPO-8854214"], "pathways": ["R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-8854214:r:TBC/RABGAPs", "R-SPO-8854214:r:TBC/RABGAPs"], "type": "Domain"}, "IPR021936": {"description": "Protein of unknown function DUF3549", "go_ids": [], "go_terms": [], "name": "DUF3549", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021937": {"description": "Protein of unknown function DUF3551", "go_ids": [], "go_terms": [], "name": "DUF3551", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021938": {"description": "Protein of unknown function DUF3553", "go_ids": [], "go_terms": [], "name": "DUF3553", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021939": {"description": "Kank N-terminal motif", "go_ids": [], "go_terms": [], "name": "KN_motif", "pathway_ids": ["R-HSA-9018519", "R-HSA-9673768"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"], "type": "Conserved_site"}, "IPR021940": {"description": "Very-long-chain aldehyde decarbonylase CER1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "CER1-like_C", "pathway_ids": ["PWY-7032", "PWY-282", "PWY-6622"], "pathways": ["PWY-7032:t:alkane biosynthesis I", "PWY-282:t:cuticular wax biosynthesis", "PWY-6622:t:heptadecane biosynthesis"], "type": "Domain"}, "IPR021941": {"description": "Protein of unknown function DUF3556, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF3556_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021942": {"description": "Protein of unknown function DUF3557", "go_ids": [], "go_terms": [], "name": "DUF3557", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021944": {"description": "Protein of unknown function DUF3560", "go_ids": [], "go_terms": [], "name": "DUF3560", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021945": {"description": "Protein of unknown function DUF3562", "go_ids": [], "go_terms": [], "name": "DUF3562", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021946": {"description": "Protein of unknown function DUF3563", "go_ids": [], "go_terms": [], "name": "DUF3563", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021947": {"description": "Protein of unknown function DUF3564", "go_ids": [], "go_terms": [], "name": "DUF3564", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021948": {"description": "Protein of unknown function DUF3565", "go_ids": [], "go_terms": [], "name": "DUF3565", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021949": {"description": "Domain of unknown function DUF3566, transmembrane domain", "go_ids": [], "go_terms": [], "name": "DUF3566_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021950": {"description": "Transcription factor Spt20", "go_ids": ["GO:0000124", "GO:0003712"], "go_terms": ["GO:0000124:SAGA complex:C", "GO:0003712:transcription coregulator activity:F"], "name": "Spt20", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR021951": {"description": "Protein of unknown function DUF3567", "go_ids": [], "go_terms": [], "name": "DUF3567", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021952": {"description": "Lipoprotein Flpp3-like", "go_ids": [], "go_terms": [], "name": "Flpp3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021953": {"description": "Protein of unknown function DUF3570", "go_ids": [], "go_terms": [], "name": "DUF3570", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021954": {"description": "Protein CHLORORESPIRATORY REDUCTION 7", "go_ids": [], "go_terms": [], "name": "CRR7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021955": {"description": "Protein of unknown function DUF3572", "go_ids": [], "go_terms": [], "name": "DUF3572", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021956": {"description": "Protein of unknown function DUF3573", "go_ids": [], "go_terms": [], "name": "DUF3573", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021957": {"description": "Protein of unknown function DUF3574", "go_ids": [], "go_terms": [], "name": "DUF3574", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021958": {"description": "Protein of unknown function DUF3575", "go_ids": [], "go_terms": [], "name": "DUF3575", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021959": {"description": "Protein of unknown function DUF3576", "go_ids": [], "go_terms": [], "name": "DUF3576", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021960": {"description": "Protein of unknown function DUF3577", "go_ids": [], "go_terms": [], "name": "DUF3577", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021961": {"description": "Type IV methyl-directed restriction enzyme EcoKMcrB subunit, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "McrB_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021962": {"description": "LipI32", "go_ids": [], "go_terms": [], "name": "Lipl32", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021963": {"description": "T cell CD4 receptor C-terminal region", "go_ids": [], "go_terms": [], "name": "Tcell_CD4_Cterm", "pathway_ids": ["R-MMU-389948", "R-MMU-8856828", "R-HSA-449836", "R-MMU-202433", "R-RNO-8856825", "R-HSA-1462054", "R-MMU-8856825", "R-HSA-202433", "R-HSA-8856828", "R-HSA-167590", "R-RNO-202433", "R-MMU-202430", "R-RNO-1462054", "R-HSA-202427", "R-RNO-202427", "R-HSA-389948", "R-HSA-8856825", "R-RNO-202424", "R-RNO-389948", "R-HSA-180534", "R-MMU-202427", "R-RNO-8856828", "R-MMU-1462054", "R-RNO-202430", "R-HSA-202430", "R-HSA-202424", "R-RNO-449836", "R-MMU-449836", "R-MMU-202424", "R-HSA-173107"], "pathways": ["R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-449836:r:Other interleukin signaling", "R-MMU-202433:r:Generation of second messenger molecules", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-1462054:r:Alpha-defensins", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-RNO-1462054:r:Alpha-defensins", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-202424:r:Downstream TCR signaling", "R-RNO-389948:r:Co-inhibition by PD-1", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1462054:r:Alpha-defensins", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-449836:r:Other interleukin signaling", "R-MMU-449836:r:Other interleukin signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-173107:r:Binding and entry of HIV virion"], "type": "Domain"}, "IPR021964": {"description": "Colicin E5 ribonuclease domain", "go_ids": ["GO:0004540"], "go_terms": ["GO:0004540:RNA nuclease activity:F"], "name": "Colicin_E5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021965": {"description": "Plasminogen ligand, VEK-30", "go_ids": [], "go_terms": [], "name": "Plasminogen_ligand_VEK-30", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021966": {"description": "Splicing factor SF3a60 binding domain", "go_ids": [], "go_terms": [], "name": "SF3a60_bindingd", "pathway_ids": ["R-DME-9770562", "R-DME-72163", "R-SPO-9770562", "R-HSA-72163", "R-HSA-9770562", "R-HSA-9918481", "R-MMU-9770562", "R-MMU-72163"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR021967": {"description": "Nuclear pore complex protein NUP96, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Nup98_C", "pathway_ids": ["PWY-7884", "R-CEL-159231", "R-HSA-180910", "R-RNO-9615933", "R-CEL-3301854", "R-CEL-159227", "R-MMU-2467813", "R-RNO-3301854", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-68877", "R-MMU-9615933", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-RNO-191859", "R-CEL-159230", "R-HSA-3371453", "R-CEL-4551638", "R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-MMU-141444", "R-DME-3371453", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-HSA-141444", "R-DME-159227", "R-HSA-168325", "R-HSA-9648025", "R-MMU-170822", "R-HSA-9609690", "R-RNO-5663220", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-9615933", "R-MMU-159227", "R-RNO-4085377", "R-HSA-9615933", "R-SPO-4570464", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-RNO-2467813", "R-HSA-159236", "R-MMU-3108214", "R-MMU-5663220", "R-RNO-141444", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-3232142", "R-SPO-159227", "R-SPO-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-HSA-168333", "R-MMU-4085377", "R-HSA-68877", "R-HSA-165054", "R-CEL-3108214", "R-RNO-159236", "R-HSA-4615885", "R-MMU-9648025", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-DME-4551638", "R-HSA-4085377", "R-RNO-159227", "R-CEL-9615933", "R-RNO-4551638", "R-DME-159230", "R-DME-3301854", "R-RNO-170822", "R-RNO-159231", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-180746", "R-CEL-3371453", "R-CEL-159236"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-191859:r:snRNP Assembly", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR021968": {"description": "Polyribonucleotide phosphorylase, C-terminal", "go_ids": [], "go_terms": [], "name": "PNPase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021969": {"description": "Protein of unknown function DUF3579", "go_ids": [], "go_terms": [], "name": "DUF3579", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021970": {"description": "Sequence-variable mosaic (SVM), signal sequence", "go_ids": [], "go_terms": [], "name": "SVM_signal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021971": {"description": "Salivary protein 15", "go_ids": [], "go_terms": [], "name": "Salp15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021972": {"description": "Parvovirus non-structural protein 1, C-terminal", "go_ids": [], "go_terms": [], "name": "Parvovirus_NS1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021973": {"description": "SprA-related family", "go_ids": [], "go_terms": [], "name": "SprA-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021974": {"description": "Protein of unknown function DUF3581", "go_ids": [], "go_terms": [], "name": "DUF3581", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021975": {"description": "Rifampin ADP-ribosyltransferase", "go_ids": [], "go_terms": [], "name": "Rifampin_Arr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021976": {"description": "N-acetylmuramoyl-l-alanine amidase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Amidase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021977": {"description": "D domain of beta-TrCP", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "Beta-TrCP_D", "pathway_ids": ["R-HSA-9020702", "R-HSA-5610785", "R-HSA-3769402", "R-MMU-5607764", "R-HSA-8951664", "R-HSA-9932298", "R-HSA-5676590", "R-MMU-2565942", "R-MMU-69601", "R-HSA-2565942", "R-MMU-8951664", "R-HSA-2871837", "R-HSA-5684264", "R-HSA-174113", "R-HSA-9762114", "R-HSA-5610783", "R-HSA-5607764", "R-MMU-202424", "R-HSA-195253", "R-MMU-5684264", "R-HSA-5610780", "R-HSA-5607761", "R-HSA-1170546", "R-MMU-1169091", "R-HSA-69601", "R-HSA-983168", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-1169091", "R-HSA-9929356", "R-MMU-2871837", "R-MMU-983168", "R-HSA-180534", "R-HSA-202424"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-8951664:r:Neddylation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8951664:r:Neddylation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-202424:r:Downstream TCR signaling"], "type": "Domain"}, "IPR021978": {"description": "PML-like, coiled-coil", "go_ids": [], "go_terms": [], "name": "PML-like_CC", "pathway_ids": ["R-HSA-3232142", "R-HSA-6804758", "R-MMU-3232142", "R-HSA-3108214", "R-HSA-9920588", "R-HSA-8948747", "R-HSA-877300", "R-MMU-6804758", "R-MMU-8948747", "R-HSA-9616222", "R-MMU-3108214", "R-MMU-8934593", "R-HSA-9609690", "R-HSA-8934593"], "pathways": ["R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity"], "type": "Domain"}, "IPR021979": {"description": "Protein of unknown function DUF3584", "go_ids": [], "go_terms": [], "name": "DUF3584", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021980": {"description": "PHTF1/2, N-terminal", "go_ids": [], "go_terms": [], "name": "PHTF1/2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021981": {"description": "Domain of unknown function DUF3586", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "DUF3586", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021982": {"description": "Repeat element protein, Ichnovirus", "go_ids": [], "go_terms": [], "name": "REEP_Ichnovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021983": {"description": "PRP8 domain IV core", "go_ids": [], "go_terms": [], "name": "PRP8_domainIV", "pathway_ids": ["R-HSA-72163", "R-CEL-72165", "R-MMU-72165", "R-MMU-72163", "R-HSA-72165", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR021984": {"description": "Plasmodium repeat", "go_ids": [], "go_terms": [], "name": "Plasmodium_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR021985": {"description": "RNA polymerase Rpo13 subunit HTH domain", "go_ids": [], "go_terms": [], "name": "RNA_pol_Rpo13", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021986": {"description": "Spherulation-specific family 4", "go_ids": [], "go_terms": [], "name": "Spherulin4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021987": {"description": "SLED domain", "go_ids": [], "go_terms": [], "name": "SLED", "pathway_ids": ["R-HSA-4655427", "R-DME-8939243", "R-HSA-3108214", "R-MMU-3899300", "R-HSA-2559580", "R-MMU-4570464", "R-MMU-8939243", "R-DME-3108214", "R-MMU-8943724", "R-DME-2559580", "R-MMU-4551638", "R-HSA-8939243", "R-DME-4570464", "R-HSA-8943724", "R-DME-3899300", "R-HSA-4570464", "R-MMU-3108214", "R-HSA-3899300", "R-HSA-4551638", "R-DME-8943724"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-8943724:r:Regulation of PTEN gene transcription"], "type": "Domain"}, "IPR021988": {"description": "Beta-mannosyltransferase", "go_ids": ["GO:0000030"], "go_terms": ["GO:0000030:mannosyltransferase activity:F"], "name": "BMT1", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR021989": {"description": "Mediator complex, subunit Med12, catenin-binding", "go_ids": ["GO:0016592", "GO:0008013"], "go_terms": ["GO:0016592:mediator complex:C", "GO:0008013:beta-catenin binding:F"], "name": "Mediator_Med12_catenin-bd", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR021990": {"description": "Mediator complex, subunit Med12, LCEWAV-domain", "go_ids": [], "go_terms": [], "name": "Mediator_Med12_LCEWAV", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR021991": {"description": "UHRF1, tandem tudor domain", "go_ids": [], "go_terms": [], "name": "TTD_dom", "pathway_ids": ["PWY-7511", "R-HSA-5334118", "R-MMU-3899300", "R-HSA-9821002", "R-HSA-3899300"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-5334118:r:DNA methylation", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-3899300:r:SUMOylation of transcription cofactors"], "type": "Domain"}, "IPR021992": {"description": "Mannan-binding protein", "go_ids": [], "go_terms": [], "name": "MVL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021993": {"description": "Putative metal-binding domain of cation transport ATPase", "go_ids": [], "go_terms": [], "name": "ATPase-cat-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021994": {"description": "Domain of unknown function DUF3592", "go_ids": [], "go_terms": [], "name": "DUF3592", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021995": {"description": "Protein of unknown function DUF3593", "go_ids": [], "go_terms": [], "name": "DUF3593", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR021996": {"description": "Fibrinogen alpha C domain", "go_ids": [], "go_terms": [], "name": "Fibrinogen_aC", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-RNO-216083", "R-HSA-6802952", "R-RNO-372708", "R-HSA-9656223", "R-HSA-977225", "R-RNO-140875", "R-RNO-354194", "R-MMU-8957275", "R-RNO-114608", "R-MMU-372708", "R-HSA-114608", "R-RNO-354192", "R-HSA-9649948", "R-HSA-6802946", "R-MMU-381426", "R-RNO-8957275", "R-RNO-5674135", "R-HSA-5686938", "R-HSA-6802955", "R-HSA-381426", "R-HSA-354192", "R-RNO-5686938", "R-HSA-166058", "R-HSA-216083", "R-HSA-6802948", "R-HSA-354194", "R-MMU-354194", "R-MMU-5686938", "R-HSA-140875", "R-MMU-140875", "R-RNO-381426", "R-MMU-216083", "R-HSA-1236974", "R-HSA-5603041", "R-HSA-5602498", "R-HSA-8957275", "R-HSA-372708", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-RNO-354192:r:Integrin signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-354192:r:Integrin signaling", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR021997": {"description": "Stage V sporulation protein AA", "go_ids": [], "go_terms": [], "name": "SporV_AA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR021998": {"description": "Alfin, N-terminal", "go_ids": ["GO:0042393", "GO:0006355"], "go_terms": ["GO:0042393:histone binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Alfin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022000": {"description": "Min27-like integrase, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "Min27-like_integrase_DNA_bind", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022001": {"description": "DNA polymerase III subunit tau, DnaB-binding domain IV", "go_ids": [], "go_terms": [], "name": "DNA_pol3_tau_IV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022002": {"description": "ChsH2, rubredoxin-like zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "ChsH2_Znr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022003": {"description": "RST domain", "go_ids": [], "go_terms": [], "name": "RST", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022004": {"description": "White spot syndrome virus structural envelope protein Vp28", "go_ids": [], "go_terms": [], "name": "WSSV_Vp28", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022005": {"description": "Prohormone convertase enzyme", "go_ids": [], "go_terms": [], "name": "Proho_convert", "pathway_ids": ["R-MMU-422085", "R-RNO-209952", "R-HSA-264876", "R-RNO-422085", "R-HSA-381771", "R-HSA-209952", "R-HSA-422085", "R-MMU-209952", "R-HSA-400511"], "pathways": ["R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-209952:r:Peptide hormone biosynthesis", "R-HSA-264876:r:Insulin processing", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-209952:r:Peptide hormone biosynthesis", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-209952:r:Peptide hormone biosynthesis", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Domain"}, "IPR022006": {"description": "Chromosome passenger complex (CPC) protein INCENP N-terminal", "go_ids": [], "go_terms": [], "name": "INCENP_N", "pathway_ids": ["R-MMU-2500257", "R-XTR-4615885", "R-XTR-9648025", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-HSA-9648025", "R-XTR-68877", "R-MMU-68877", "R-MMU-4615885", "R-XTR-141444", "R-HSA-68877", "R-HSA-5663220", "R-HSA-4615885", "R-MMU-9648025", "R-XTR-2500257", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR022007": {"description": "I-kappa-kinase-beta NEMO binding domain", "go_ids": ["GO:0008384"], "go_terms": ["GO:0008384:IkappaB kinase activity:F"], "name": "IKKbetaNEMObind", "pathway_ids": ["R-BTA-9909505", "R-MMU-9909505", "R-HSA-9020702", "R-RNO-9758274", "R-DRE-1169091", "R-RNO-9020702", "R-HSA-168638", "R-MMU-5607764", "R-HSA-9833482", "R-MMU-198323", "R-BTA-202424", "R-MMU-9020702", "R-RNO-5357905", "R-HSA-5676590", "R-BTA-975144", "R-MMU-933542", "R-DRE-198323", "R-DRE-445989", "R-MMU-9833482", "R-HSA-5684264", "R-MMU-445989", "R-BTA-9758274", "R-HSA-168927", "R-BTA-1169091", "R-MMU-1810476", "R-BTA-937041", "R-RNO-202424", "R-HSA-937041", "R-DRE-9020702", "R-BTA-5607761", "R-GGA-1227892", "R-MMU-5684264", "R-HSA-5603029", "R-HSA-5607761", "R-MMU-975144", "R-BTA-5357905", "R-HSA-209560", "R-RNO-975144", "R-MMU-209543", "R-HSA-975144", "R-HSA-5674400", "R-RNO-209560", "R-HSA-9758274", "R-GGA-434131", "R-BTA-5684264", "R-MMU-9860276", "R-HSA-5602636", "R-RNO-209543", "R-HSA-9860276", "R-HSA-1169091", "R-DRE-5357905", "R-DRE-5684264", "R-BTA-1810476", "R-MMU-2871837", "R-BTA-933542", "R-MMU-5357905", "R-RNO-445989", "R-HSA-1236974", "R-DRE-5607761", "R-HSA-9860927", "R-BTA-937039", "R-BTA-9833482", "R-DRE-937039", "R-MMU-9860927", "R-RNO-933542", "R-HSA-445989", "R-HSA-9705671", "R-RNO-9860276", "R-BTA-5357956", "R-RNO-9833482", "R-HSA-209543", "R-HSA-933542", "R-RNO-9909505", "R-MMU-5357956", "R-BTA-5676590", "R-DRE-9833482", "R-HSA-9909505", "R-HSA-198323", "R-RNO-9860927", "R-HSA-2871837", "R-BTA-2871837", "R-HSA-5357905", "R-MMU-937039", "R-BTA-209543", "R-BTA-445989", "R-DRE-5676590", "R-HSA-5607764", "R-BTA-209560", "R-RNO-1810476", "R-MMU-202424", "R-RNO-937039", "R-RNO-937041", "R-GGA-1227739", "R-MMU-209560", "R-RNO-5684264", "R-BTA-9860276", "R-MMU-1169091", "R-GGA-434001", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-1810476", "R-BTA-9860927", "R-DRE-975144", "R-HSA-5603027", "R-HSA-5357956", "R-RNO-5607764", "R-RNO-1169091", "R-HSA-933543", "R-BTA-9020702", "R-BTA-5607764", "R-RNO-5357956", "R-MMU-9758274", "R-HSA-202424", "R-MMU-937041", "R-DRE-9758274", "R-HSA-937039", "R-RNO-2871837"], "pathways": ["R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5676590:r:NIK-->noncanonical 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"R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-5602636:r:IKBKB deficiency causes SCID", 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"R-HSA-3301854", "R-MMU-159227", "R-HSA-5619107", "R-HSA-5663220", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-HSA-9725370", "R-MMU-5663220"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-191859:r:snRNP Assembly", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage 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"R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-141444:r:Amplification 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"pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022017": {"description": "Biogenesis factor required for ATP synthase 1-like, DUF3598", "go_ids": [], "go_terms": [], "name": "BFA1-like_DUF3598", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022018": {"description": "ARF GTPase-activating protein GIT1, C-terminal", "go_ids": [], "go_terms": [], "name": "GIT1_C", "pathway_ids": ["R-HSA-9013409", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-DME-9013424", "R-HSA-9013423", "R-MMU-9013420", "R-RNO-9013424", "R-HSA-9013148", "R-DME-9013406", "R-DME-3928664", "R-HSA-9619229", "R-RNO-9013404", "R-RNO-9013406", "R-MMU-3928664", "R-DME-9013149", "R-HSA-9013420", "R-HSA-3928664", "R-MMU-9013424", "R-RNO-9013420", "R-RNO-3928664", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-9013423", "R-HSA-9013149", "R-MMU-9013406", "R-HSA-9013406", "R-MMU-9013149", "R-DME-9013423", "R-DME-9013420"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", 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"R-DME-9013423:r:RAC3 GTPase cycle", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR022019": {"description": "Domain of unknown function DUF3600", "go_ids": [], "go_terms": [], "name": "DUF3600", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022020": {"description": "Domain of unknown function DUF3601", "go_ids": [], "go_terms": [], "name": "DUF3601", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022022": {"description": "Immune evasion protein", "go_ids": [], "go_terms": [], "name": "M04gp34-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022023": {"description": "U1 small nuclear ribonucleoprotein of 70kDa N-terminal", "go_ids": [], "go_terms": [], "name": "U1snRNP70_N", "pathway_ids": ["R-DME-9770562", "R-SPO-9770562", "R-HSA-72163", "R-DDI-9770562", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-XTR-9770562"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA 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"R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR022031": {"description": "Telomere-associated protein Rif1, N-terminal", "go_ids": [], "go_terms": [], "name": "Rif1_N", "pathway_ids": ["R-MMU-5693571", "R-HSA-5693571"], "pathways": ["R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Domain"}, "IPR022032": {"description": "Myogenic determination factor 5", "go_ids": [], "go_terms": [], "name": "Myf5", "pathway_ids": ["R-MMU-525793", "R-HSA-9839394", "R-HSA-525793", "R-RNO-525793", "R-BTA-525793"], "pathways": ["R-MMU-525793:r:Myogenesis", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-525793:r:Myogenesis", "R-RNO-525793:r:Myogenesis", "R-BTA-525793:r:Myogenesis"], "type": "Domain"}, "IPR022033": {"description": "RAVE complex protein Rav1 C-terminal", "go_ids": [], "go_terms": [], "name": "Rav1p_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022034": {"description": "Fragile X messenger 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"R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-3214847:r:HATs acetylate histones", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-156711:r:Polo-like kinase mediated events", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-XTR-8951664:r:Neddylation", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-SCE-3214815:r:HDACs deacetylate histones", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-3214815:r:HDACs deacetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3214847:r:HATs acetylate histones", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR022053": {"description": "Protein of unknown function DUF3613", "go_ids": [], "go_terms": [], "name": "DUF3613", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022054": {"description": "Protein of unknown function DUF3614", "go_ids": [], "go_terms": [], "name": "DUF3614", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022055": {"description": "Protein of unknown function DUF3612", "go_ids": [], "go_terms": [], "name": "DUF3612", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022056": {"description": "CpG binding protein, C-terminal", "go_ids": [], "go_terms": [], "name": "CpG-bd_C", "pathway_ids": ["R-BTA-9772755", "R-MMU-9772755", "R-HSA-381038", "R-CEL-9772755", "R-DME-9772755", "R-HSA-9772755"], "pathways": ["R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Domain"}, "IPR022057": {"description": "Chitin synthase export chaperone", "go_ids": [], "go_terms": [], "name": "Chs7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022059": {"description": "Domain of unknown function DUF3615", "go_ids": [], "go_terms": [], "name": "DUF3615", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022060": {"description": "Domain of unknown function DUF3616", "go_ids": [], "go_terms": [], "name": "DUF3616", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022061": {"description": "Protein of unknown function DUF3617", "go_ids": [], "go_terms": [], "name": "DUF3617", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022062": {"description": "Protein of unknown function DUF3618", "go_ids": [], "go_terms": [], "name": "DUF3618", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022063": {"description": "Complementary sex determination, N-terminal", "go_ids": [], "go_terms": [], "name": "Sex_determin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022064": {"description": "Protein of unknown function DUF3619", "go_ids": [], "go_terms": [], "name": "DUF3619", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022065": {"description": "Uncharacterised protein family, TMEM59", "go_ids": [], "go_terms": [], "name": "Uncharacterised_TMEM59", "pathway_ids": ["R-BTA-9013407", "R-SSC-9013407", "R-MMU-9013407", "R-BTA-9696273", "R-SSC-9696273", "R-HSA-9696273", "R-MMU-9696273", "R-HSA-9013407"], "pathways": ["R-BTA-9013407:r:RHOH GTPase cycle", "R-SSC-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-BTA-9696273:r:RND1 GTPase cycle", "R-SSC-9696273:r:RND1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR022066": {"description": "Histidine kinase PdtaS, GAF domain", "go_ids": [], "go_terms": [], "name": "PdtaS_GAF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022067": {"description": "Homeobox protein Hox1A3 N-terminal", "go_ids": [], "go_terms": [], "name": "HoxA13_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022068": {"description": "Mamastrovirus p20 protein", "go_ids": ["GO:0070008", "GO:0004252"], "go_terms": ["GO:0070008:serine-type exopeptidase activity:F", "GO:0004252:serine-type endopeptidase activity:F"], "name": "Mamastrovirus_p20", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR022069": {"description": "Protein of unknown function DUF3622", "go_ids": [], "go_terms": [], "name": "DUF3622", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022070": {"description": "Cytoplasmic activation/proliferation-associated protein-1 C term", "go_ids": [], "go_terms": [], "name": "Caprin-1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022071": {"description": "Rotavirus VP1 RNA-directed RNA polymerase, C-terminal", "go_ids": ["GO:0003968"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F"], "name": "Rotavirus_VP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022072": {"description": "Protein of unknown function DUF3624", "go_ids": [], "go_terms": [], "name": "DUF3624", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022073": {"description": "Putative outer membrane core complex of type IVb secretion", "go_ids": [], "go_terms": [], "name": "T4BSS_DotH_IcmK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022074": {"description": "Protein of unknown function DUF3626", "go_ids": [], "go_terms": [], "name": "DUF3626", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022075": {"description": "Symplekin C-terminal", "go_ids": [], "go_terms": [], "name": "Symplekin_C", "pathway_ids": ["R-DME-9770562", "R-HSA-77595", "R-MMU-72187", "R-HSA-9770562", "R-DME-77595", "R-MMU-9770562", "R-MMU-77595", "R-MMU-73856", "R-DME-159231", "R-DME-73856", "R-HSA-73856", "R-HSA-72187", "R-HSA-9918481", "R-MMU-159231", "R-HSA-159231"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript"], "type": "Domain"}, "IPR022076": {"description": "Limbin", "go_ids": ["GO:0007224"], "go_terms": ["GO:0007224:smoothened signaling pathway:P"], "name": "Limbin", "pathway_ids": ["R-HSA-5635838", "R-HSA-5632684", "R-MMU-5632684"], "pathways": ["R-HSA-5635838:r:Activation of SMO", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-5632684:r:Hedgehog 'on' state"], "type": "Family"}, "IPR022077": {"description": "ATP-dependent RNA helicase RhlB", "go_ids": ["GO:0016817"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F"], "name": "RhlB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022078": {"description": "CD99 antigen-like protein 2", "go_ids": [], "go_terms": [], "name": "CD99L2", "pathway_ids": ["R-HSA-198933", "R-HSA-202733"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR022079": {"description": "Protein of unknown function DUF3629", "go_ids": [], "go_terms": [], "name": "DUF3629", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022080": {"description": "Protein of unknown function DUF3630", "go_ids": [], "go_terms": [], "name": "DUF3630", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022081": {"description": "Domain of unknown function DUF3631", "go_ids": [], "go_terms": [], "name": "DUF3631", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022082": {"description": "Noelin domain", "go_ids": [], "go_terms": [], "name": "Noelin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022083": {"description": "KIF-1 binding protein", "go_ids": [], "go_terms": [], "name": "KBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022084": {"description": "Transcription factor Elf, N-terminal", "go_ids": [], "go_terms": [], "name": "TF_Elf_N", "pathway_ids": ["R-MMU-8939247", "R-HSA-8939247", "R-HSA-8939245", "R-MMU-8939245", "R-BTA-8939247"], "pathways": ["R-MMU-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-BTA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling"], "type": "Domain"}, "IPR022085": {"description": "Oxopyrrolidines biosynthesis cluster protein G", "go_ids": [], "go_terms": [], "name": "OpdG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022086": {"description": "Inner membrane complex protein", "go_ids": [], "go_terms": [], "name": "IMCp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022087": {"description": "Protein DA1-like domain", "go_ids": [], "go_terms": [], "name": "DA1-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022088": {"description": "Intraflagellar transport complex B protein 46", "go_ids": ["GO:0042073"], "go_terms": ["GO:0042073:intraciliary transport:P"], "name": "Intraflagellar_transp_cmplxB", "pathway_ids": ["R-BTA-5620924", "R-HSA-5620924", "R-RNO-5620924", "R-CEL-5620924", "R-MMU-5620924"], "pathways": ["R-BTA-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR022089": {"description": "Tryptophan/threonine-rich plasmodium antigen, C-terminal", "go_ids": [], "go_terms": [], "name": "Plasmodium-antigen_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022090": {"description": "Protein of unknown function DUF3634", "go_ids": [], "go_terms": [], "name": "DUF3634", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022091": {"description": "Golgin TMF1, C-terminal", "go_ids": [], "go_terms": [], "name": "Golgin_TMF_C", "pathway_ids": ["R-HSA-6811440", "R-SCE-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR022092": {"description": "Golgin TMF1, middle domain", "go_ids": [], "go_terms": [], "name": "Golgin_TMF_M", "pathway_ids": ["R-HSA-6811440", "R-SCE-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR022093": {"description": "Rad26-like, helical repeats", "go_ids": [], "go_terms": [], "name": "Rad26-like_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022095": {"description": "Outer membrane protein B, passenger domain, Rickettsia", "go_ids": [], "go_terms": [], "name": "OmpB_passenger_Rickettsia", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022096": {"description": "SBF1/SBF2 domain", "go_ids": [], "go_terms": [], "name": "SBF1/SBF2", "pathway_ids": ["R-HSA-1483248", "R-HSA-8876198", "R-MMU-8876198", "R-CEL-8876198", "R-MMU-1483248", "R-HSA-1660499", "R-CEL-1483248"], "pathways": ["R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane"], "type": "Domain"}, "IPR022097": {"description": "Transcription factor SOX", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "SOX_fam", "pathway_ids": ["R-MMU-3769402", "R-HSA-9754189", "R-HSA-2892245", "R-XTR-3769402", "R-DRE-3769402", "R-HSA-9832991", "R-HSA-3769402", "R-HSA-9926550", "R-HSA-9856649", "R-HSA-8986944", "R-HSA-452723", "R-HSA-2892247", "R-HSA-6785807", "R-HSA-9834899", "R-HSA-9823739"], "pathways": ["R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-2892245:r:POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "R-XTR-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9832991:r:Formation of the posterior neural plate", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-9823739:r:Formation of the anterior neural plate"], "type": "Family"}, "IPR022098": {"description": "Protein of unknown function DUF3637", "go_ids": [], "go_terms": [], "name": "DUF3637", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022099": {"description": "Domain of unknown function DUF3638", "go_ids": [], "go_terms": [], "name": "DUF3638", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022100": {"description": "WDHD1/CFT4, second beta-propeller", "go_ids": [], "go_terms": [], "name": "WDHD1/CFT4_beta-prop_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022101": {"description": "GB virus C, polyprotein N-terminal", "go_ids": [], "go_terms": [], "name": "GB_virus-C_polyprotein_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022102": {"description": "Holliday junction regulator protein family C-terminal", "go_ids": [], "go_terms": [], "name": "HJURP_C", "pathway_ids": ["R-MMU-69273", "R-HSA-525793", "R-HSA-9931509", "R-RNO-525793", "R-HSA-9022707", "R-BTA-525793", "R-HSA-198753", "R-HSA-606279", "R-HSA-2151201", "R-HSA-9733709", "R-HSA-69273", "R-MMU-606279", "R-HSA-9707616", "R-MMU-525793", "R-DME-525793", "R-HSA-9031628"], "pathways": ["R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-525793:r:Myogenesis", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-RNO-525793:r:Myogenesis", "R-HSA-9022707:r:MECP2 regulates transcription factors", "R-BTA-525793:r:Myogenesis", "R-HSA-198753:r:ERK/MAPK targets", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9707616:r:Heme signaling", "R-MMU-525793:r:Myogenesis", "R-DME-525793:r:Myogenesis", "R-HSA-9031628:r:NGF-stimulated transcription"], "type": "Domain"}, "IPR022103": {"description": "Baculoviral IAP repeat-containing protein 6", "go_ids": ["GO:0006915", "GO:0032465", "GO:0004842"], "go_terms": ["GO:0006915:apoptotic process:P", "GO:0032465:regulation of cytokinesis:P", "GO:0004842:ubiquitin-protein transferase activity:F"], "name": "BIRC6", "pathway_ids": ["R-HSA-9700645", "R-HSA-9725370"], "pathways": ["R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Family"}, "IPR022104": {"description": "Domain of unknown function DUF3644", "go_ids": [], "go_terms": [], "name": "DUF3644", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022105": {"description": "Domain of unknown function DUF3645", "go_ids": [], "go_terms": [], "name": "DUF3645", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022106": {"description": "Paired box protein 7, C-terminal", "go_ids": [], "go_terms": [], "name": "Pax7_C", "pathway_ids": ["R-MMU-3214847", "R-HSA-3214847", "R-HSA-9856649", "R-HSA-9834899"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9834899:r:Specification of the neural plate border"], "type": "Domain"}, "IPR022107": {"description": "DNA polymerase III, subunit gamma/ tau, C-terminal", "go_ids": [], "go_terms": [], "name": "DNA_pol_III_gamma/tau_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022108": {"description": "Protein of unknown function DUF3648", "go_ids": [], "go_terms": [], "name": "DUF3648", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022109": {"description": "Protein of unknown function DUF3649", "go_ids": [], "go_terms": [], "name": "DUF3649", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022110": {"description": "CASC1, C-terminal", "go_ids": [], "go_terms": [], "name": "CASC1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022111": {"description": "Rhodanese, C-terminal", "go_ids": [], "go_terms": [], "name": "Rhodanese_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022113": {"description": "Transmembrane protein 131-like, N-terminal", "go_ids": [], "go_terms": [], "name": "TMEM131L_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022114": {"description": "Doublesex- and mab-3-related transcription factor 1-like", "go_ids": [], "go_terms": [], "name": "DMRT1-like", "pathway_ids": ["R-HSA-9690406"], "pathways": ["R-HSA-9690406:r:Transcriptional regulation of testis differentiation"], "type": "Family"}, "IPR022115": {"description": "Protein of unknown function DUF3654", "go_ids": [], "go_terms": [], "name": "DUF3654", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022116": {"description": "Adhesin P1, N-terminal", "go_ids": [], "go_terms": [], "name": "P1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022117": {"description": "Severe acute respiratory syndrome coronavirus 3b protein", "go_ids": [], "go_terms": [], "name": "SARS_3b", "pathway_ids": ["R-HSA-9692916"], "pathways": ["R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Family"}, "IPR022118": {"description": "Peptidase C70, AvrRpt2", "go_ids": [], "go_terms": [], "name": "Peptidase_C70_AvrRpt2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022119": {"description": "Pseudomurein endoisopeptidase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Pei_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022120": {"description": "Pestivirus nonstructural protein 2", "go_ids": ["GO:0004197", "GO:0017111", "GO:0016817", "GO:0003968", "GO:0070008", "GO:0004252"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F", "GO:0017111:ribonucleoside triphosphate phosphatase activity:F", "GO:0016817:hydrolase activity, acting on acid anhydrides:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0070008:serine-type exopeptidase activity:F", "GO:0004252:serine-type endopeptidase activity:F"], "name": "NS2", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Family"}, "IPR022121": {"description": "Peptidase M73, camelysin", "go_ids": [], "go_terms": [], "name": "Peptidase_M73_camelysin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022122": {"description": "Protein FAM135", "go_ids": [], "go_terms": [], "name": "DUF3657", "pathway_ids": ["R-HSA-9696273", "R-MMU-9696273"], "pathways": ["R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle"], "type": "Family"}, "IPR022123": {"description": "Domain of unknown function DUF3658", "go_ids": [], "go_terms": [], "name": "DUF3658", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022124": {"description": "VDAG_07280, repeated domain", "go_ids": [], "go_terms": [], "name": "VDAG_07280_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022125": {"description": "U3 small nucleolar RNA-associated protein 10, N-terminal", "go_ids": [], "go_terms": [], "name": "U3snoRNP10_N", "pathway_ids": ["R-DME-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR022126": {"description": "S-locus, receptor kinase", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "S-locus_recpt_kinase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022127": {"description": "Store-operated calcium entry regulator STIMATE/YPL162C", "go_ids": [], "go_terms": [], "name": "STIMATE/YPL162C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022128": {"description": "FhaA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FhaA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022129": {"description": "Transcriptional repressor NocA-like", "go_ids": [], "go_terms": [], "name": "Tscrpt_rep_NocA-like", "pathway_ids": ["R-MMU-212436", "R-HSA-212436"], "pathways": ["R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway"], "type": "Family"}, "IPR022130": {"description": "Paired-box protein 2 C-terminal", "go_ids": [], "go_terms": [], "name": "Pax2_C", "pathway_ids": ["R-HSA-9830674", "R-HSA-9761174", "R-HSA-8939245", "R-MMU-8939245", "R-HSA-9830364"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-9761174:r:Formation of intermediate mesoderm", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-9830364:r:Formation of the nephric duct"], "type": "Domain"}, "IPR022131": {"description": "Protein of unknown function DUF3664, surface protein", "go_ids": [], "go_terms": [], "name": "DUF3664", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022132": {"description": "Homeobox protein", "go_ids": [], "go_terms": [], "name": "Abdominal-A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022133": {"description": "Ribose-5-phosphate isomerase, C-terminal", "go_ids": [], "go_terms": [], "name": "Ribose_5_isomerase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022134": {"description": "Protein of unknown function DUF3667", "go_ids": [], "go_terms": [], "name": "DUF3667", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022135": {"description": "Distal-less-like homeobox protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Distal-less_N", "pathway_ids": ["R-HSA-8939902", "R-HSA-9834899", "R-HSA-9938206"], "pathways": ["R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells"], "type": "Domain"}, "IPR022136": {"description": "Domain of unknown function DUF3668", "go_ids": [], "go_terms": [], "name": "DUF3668", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022137": {"description": "Zinc finger protein, DUF3669 domain", "go_ids": [], "go_terms": [], "name": "Znf_prot_DUF3669", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022138": {"description": "Domain of unknown function DUF3670", "go_ids": [], "go_terms": [], "name": "DUF3670", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022139": {"description": "Fam-L/Fam-M-like, plasmodium", "go_ids": [], "go_terms": [], "name": "Fam-L/Fam-M-like_plasmodium", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022140": {"description": "Kinesin-like KIF1-type", "go_ids": [], "go_terms": [], "name": "Kinesin-like_KIF1-typ", "pathway_ids": ["R-HSA-6811434", "R-RNO-6811434", "R-HSA-390471", "R-HSA-983189", "R-RNO-983189", "R-MMU-983189", "R-MMU-6811434"], "pathways": ["R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-983189:r:Kinesins", "R-RNO-983189:r:Kinesins", "R-MMU-983189:r:Kinesins", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR022141": {"description": "Plasma membrane calcium transporting P-type ATPase, C-terminal", "go_ids": ["GO:0005388"], "go_terms": ["GO:0005388:P-type calcium transporter activity:F"], "name": "ATP_Ca_trans_C", "pathway_ids": ["R-GGA-936837", "R-GGA-418359", "R-GGA-5578775", "R-RNO-5578775", "R-HSA-9662361", "R-RNO-418359", "R-MMU-5578775", "R-HSA-936837", "R-BTA-936837", "R-RNO-936837", "R-MMU-418359", "R-HSA-9662360", "R-BTA-5578775", "R-HSA-5578775", "R-MMU-936837", "R-BTA-418359", "R-HSA-418359"], "pathways": ["R-GGA-936837:r:Ion transport by P-type ATPases", "R-GGA-418359:r:Reduction of cytosolic Ca++ levels", "R-GGA-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-BTA-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Domain"}, "IPR022142": {"description": "Protein of unknown function DUF3673", "go_ids": [], "go_terms": [], "name": "DUF3673", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022143": {"description": "Protein of unknown function DUF3675", "go_ids": [], "go_terms": [], "name": "DUF3675", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022144": {"description": "Domain of unknown function DUF3676", "go_ids": [], "go_terms": [], "name": "DUF3676", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022145": {"description": "Integrator complex subunit 1, RPB2-binding domain", "go_ids": [], "go_terms": [], "name": "INTS1_RPB2-bd", "pathway_ids": ["R-DME-6807505", "R-MMU-6807505", "R-HSA-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR022146": {"description": "Protein of unknown function DUF3678", "go_ids": [], "go_terms": [], "name": "DUF3678", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022147": {"description": "Glutamine synthetase type III N-terminal", "go_ids": ["GO:0004356"], "go_terms": ["GO:0004356:glutamine synthetase activity:F"], "name": "GSIII_N", "pathway_ids": ["PWY-6964", "PWY-8294", "PWY-8291", "PWY-6963"], "pathways": ["PWY-6964:t:ammonia assimilation cycle II", "PWY-8294:t:L-aspartate degradation III (anaerobic)", "PWY-8291:t:L-aspartate degradation II (aerobic)", "PWY-6963:t:ammonia assimilation cycle I"], "type": "Domain"}, "IPR022148": {"description": "CopG antitoxin", "go_ids": [], "go_terms": [], "name": "CopG_antitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022149": {"description": "Protein of unknown function DUF3681", "go_ids": [], "go_terms": [], "name": "DUF3681", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022150": {"description": "AKNA domain", "go_ids": [], "go_terms": [], "name": "AKNA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022151": {"description": "Sox developmental protein N-terminal", "go_ids": [], "go_terms": [], "name": "Sox_N", "pathway_ids": ["R-MMU-9856649", "R-MMU-3769402", "R-HSA-9925563", "R-XTR-9856649", "R-HSA-3769402", "R-RNO-9856649", "R-SSC-9856649", "R-HSA-9937080", "R-HSA-9619665", "R-HSA-9925561", "R-HSA-9764302", "R-MMU-8878166", "R-HSA-9824585", "R-XTR-3769402", "R-GGA-8878166", "R-XTR-8878166", "R-HSA-9856649", "R-RNO-3769402", "R-HSA-8878166", "R-GGA-3769402", "R-HSA-9690406"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-XTR-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SSC-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-XTR-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-GGA-8878166:r:Transcriptional regulation by RUNX2", "R-XTR-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-GGA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation"], "type": "Domain"}, "IPR022152": {"description": "Protein of unknown function DUF3682", "go_ids": [], "go_terms": [], "name": "DUF3682", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022153": {"description": "Protein of unknown function DUF3683", "go_ids": [], "go_terms": [], "name": "DUF3683", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022154": {"description": "Trafficking kinesin-binding protein, C-terminal", "go_ids": [], "go_terms": [], "name": "TRAK1/2_C", "pathway_ids": ["R-HSA-9013425", "R-HSA-6802952", "R-DME-9013419", "R-MMU-9013425", "R-RNO-9013419", "R-DME-9013425", "R-HSA-9013419", "R-MMU-9013419"], "pathways": ["R-HSA-9013425:r:RHOT1 GTPase cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-MMU-9013419:r:RHOT2 GTPase cycle"], "type": "Domain"}, "IPR022155": {"description": "Protein of unknown function DUF3684", "go_ids": [], "go_terms": [], "name": "DUF3684", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022156": {"description": "Uncharacterised protein YfbK, N-terminal", "go_ids": [], "go_terms": [], "name": "Uncharacterised_YfbK_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022157": {"description": "Dynein associated protein", "go_ids": [], "go_terms": [], "name": "Dynactin", "pathway_ids": ["R-SSC-380270", "R-HSA-2132295", "R-SSC-3371497", "R-RNO-3371497", "R-HSA-380284", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-SSC-2132295", "R-RNO-2565942", "R-MMU-2132295", "R-RNO-380284", "R-SSC-2565942", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-6811436", "R-HSA-381038", "R-SSC-8854518", "R-RNO-2132295", "R-SSC-5620912", "R-SSC-380259", "R-MMU-380259", "R-RNO-8854518", "R-RNO-6807878", "R-HSA-6807878", "R-MMU-380270", "R-HSA-380270", "R-RNO-380259", "R-MMU-6811436", "R-SSC-380284", "R-RNO-6811436", "R-SSC-6807878", "R-MMU-8854518", "R-SSC-380320", "R-HSA-380259", "R-HSA-9725370", "R-RNO-380270", "R-MMU-3371497"], "pathways": ["R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-2132295:r:MHC class II antigen presentation", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-RNO-2132295:r:MHC class II antigen presentation", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "type": "Domain"}, "IPR022158": {"description": "Inositol phosphatase", "go_ids": [], "go_terms": [], "name": "Inositol_phosphatase", "pathway_ids": ["R-DRE-1660516", "R-MMU-1660516", "R-HSA-1660516"], "pathways": ["R-DRE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane"], "type": "Domain"}, "IPR022159": {"description": "Tuftelin interacting protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "STIP/TFIP11_N", "pathway_ids": ["R-SSC-72163", "R-HSA-72163", "R-RNO-72163", "R-MMU-72163"], "pathways": ["R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR022160": {"description": "Spiroplasma phage 1-C74, Orf1", "go_ids": [], "go_terms": [], "name": "Phage_1-C74_Orf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022161": {"description": "DNA helicase IV, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Helicase_IV_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022162": {"description": "Short transient receptor potential channel 4-associated protein", "go_ids": ["GO:0031464", "GO:0006511"], "go_terms": ["GO:0031464:Cul4A-RING E3 ubiquitin ligase complex:C", "GO:0006511:ubiquitin-dependent protein catabolic process:P"], "name": "TRPC4AP", "pathway_ids": ["R-MMU-3295583", "R-HSA-3295583"], "pathways": ["R-MMU-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Family"}, "IPR022163": {"description": "GTP cyclohydrolase N-terminal", "go_ids": [], "go_terms": [], "name": "GTP_CH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022164": {"description": "Kinesin-like", "go_ids": [], "go_terms": [], "name": "Kinesin-like", "pathway_ids": ["R-HSA-6811434", "R-RNO-6811434", "R-HSA-390471", "R-HSA-983189", "R-RNO-983189", "R-HSA-8854214", "R-MMU-983189", "R-CEL-8854214", "R-MMU-8854214", "R-MMU-6811434"], "pathways": ["R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-983189:r:Kinesins", "R-RNO-983189:r:Kinesins", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-983189:r:Kinesins", "R-CEL-8854214:r:TBC/RABGAPs", "R-MMU-8854214:r:TBC/RABGAPs", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR022165": {"description": "Polo kinase kinase", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "PKK", "pathway_ids": ["R-RNO-9013026", "R-HSA-6798695", "R-DRE-9013106", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-HSA-9013106", "R-HSA-8980692", "R-DRE-6798695", "R-MMU-9013026", "R-HSA-9013026", "R-MMU-6798695", "R-DRE-9013026", "R-RNO-9013106", "R-DRE-8980692", "R-RNO-6798695"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-9013106:r:RHOC GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-9013026:r:RHOB GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR022166": {"description": "UBAP2/protein lingerer", "go_ids": [], "go_terms": [], "name": "UBAP2/Lig", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022167": {"description": "Protein of unknown function DUF3698", "go_ids": [], "go_terms": [], "name": "DUF3698", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022168": {"description": "Golgi associated RAB2 interactor protein-like, Rab2B-binding domain", "go_ids": [], "go_terms": [], "name": "GARIL-like_Rab2B-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022169": {"description": "Protein of unknown function DUF3701", "go_ids": [], "go_terms": [], "name": "DUF3701", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022170": {"description": "E3 Ubiquitin ligase MUL1-like", "go_ids": ["GO:0006996", "GO:0016567", "GO:0004842"], "go_terms": ["GO:0006996:organelle organization:P", "GO:0016567:protein ubiquitination:P", "GO:0004842:ubiquitin-protein transferase activity:F"], "name": "MUL1-like", "pathway_ids": ["PWY-7511", "R-MMU-8951664", "R-MMU-5689880", "R-HSA-5689880", "R-HSA-8951664", "R-DME-8951664", "R-HSA-9755511", "R-MMU-9755511", "R-DME-5689880", "R-DME-9755511"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway"], "type": "Domain"}, "IPR022171": {"description": "PPE, C-terminal", "go_ids": [], "go_terms": [], "name": "PPE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022172": {"description": "Protein of unknown function DUF3703", "go_ids": [], "go_terms": [], "name": "DUF3703", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022174": {"description": "Nuclear receptor coactivator 4, N-terminal", "go_ids": [], "go_terms": [], "name": "NCOA4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022175": {"description": "BCAS3 domain", "go_ids": [], "go_terms": [], "name": "BCAS3_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022176": {"description": "Apolipoprotein B100 C-terminal", "go_ids": [], "go_terms": [], "name": "ApoB100_C", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-HSA-8964038", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-RNO-5686938", "R-MMU-3000471", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-HSA-8957275", "R-RNO-3000480", "R-HSA-202733", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964038:r:LDL clearance", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR022178": {"description": "Protein of unknown function DUF3709", "go_ids": [], "go_terms": [], "name": "DUF3709", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022179": {"description": "Cilia- and flagella-associated protein 276", "go_ids": [], "go_terms": [], "name": "CFAP276", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022180": {"description": "Vegetative insecticide protein 3", "go_ids": [], "go_terms": [], "name": "Vip3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022181": {"description": "Bcl2-/adenovirus E1B 19kDa-interacting protein 2", "go_ids": [], "go_terms": [], "name": "Bcl2-/adenovirus-E1B", "pathway_ids": ["R-HSA-525793", "R-MMU-525793"], "pathways": ["R-HSA-525793:r:Myogenesis", "R-MMU-525793:r:Myogenesis"], "type": "Family"}, "IPR022182": {"description": "ABC transporter phosphate permease PstC, N-terminal domain", "go_ids": ["GO:0006817"], "go_terms": ["GO:0006817:phosphate ion transport:P"], "name": "PstC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022183": {"description": "Protein of unknown function DUF3710", "go_ids": [], "go_terms": [], "name": "DUF3710", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022184": {"description": "Cucumber mosaic virus 1a protein C-terminal", "go_ids": ["GO:0016817", "GO:0008168"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F", "GO:0008168:methyltransferase activity:F"], "name": "CMV_1a_C", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7250", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR022185": {"description": "Protein of unknown function DUF3712", "go_ids": [], "go_terms": [], "name": "DUF3712", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022186": {"description": "Protein of unknown function DUF3713", "go_ids": [], "go_terms": [], "name": "DUF3713", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022187": {"description": "Conjugative transposon, TraM", "go_ids": [], "go_terms": [], "name": "Conjug_transposon_TraM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022188": {"description": "TASOR, DUF3715", "go_ids": [], "go_terms": [], "name": "TASOR_DUF3715", "pathway_ids": ["R-HSA-9843970"], "pathways": ["R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "type": "Domain"}, "IPR022189": {"description": "Smoothelin", "go_ids": [], "go_terms": [], "name": "SMTN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022190": {"description": "Protein of unknown function DUF3716", "go_ids": [], "go_terms": [], "name": "DUF3716", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022191": {"description": "Protein of unknown function DUF3717", "go_ids": [], "go_terms": [], "name": "DUF3717", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022192": {"description": "ATP-dependent RNA helicase SUV3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SUV3_C", "pathway_ids": ["R-HSA-9836573"], "pathways": ["R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Domain"}, "IPR022193": {"description": "Protein of unknown function DUF3718", "go_ids": [], "go_terms": [], "name": "DUF3718", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022194": {"description": "Domain of unknown function DUF3719", "go_ids": [], "go_terms": [], "name": "DUF3719", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022195": {"description": "Protein of unknown function DUF3720", "go_ids": [], "go_terms": [], "name": "DUF3720", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022196": {"description": "Domain of unknown function DUF3721", "go_ids": [], "go_terms": [], "name": "DUF3721", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022198": {"description": "Domain of unknown function DUF3723", "go_ids": [], "go_terms": [], "name": "DUF3723", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022199": {"description": "Domain of unknown function DUF3725", "go_ids": [], "go_terms": [], "name": "DUF3725", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022200": {"description": "Herpesvirus glycoprotein L, C-terminal", "go_ids": [], "go_terms": [], "name": "Herpes_gL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022201": {"description": "Protein of unknown function DUF3726", "go_ids": [], "go_terms": [], "name": "DUF3726", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022202": {"description": "Hepatitis E virus, hinge domain", "go_ids": [], "go_terms": [], "name": "Hepatitis-E_hinge", "pathway_ids": ["PWY-7045", "PWY-5381", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-7706", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-5316", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-7529", "PWY-8076", "PWY-5479", "PWY-6322", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-7342", "PWY-7904", "PWY-6736", "PWY-6998", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-7888", "PWY-5773", "PWY-7155", "PWY-7719", "PWY-7076", "PWY-7737", "PWY-8106", "PWY-6682", "PWY-8104", "PWY-7419", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-6749", "PWY-7668", "PWY-8179", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-7769", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-7127", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6626", "PWY-6286", "PWY-6581", "PWY-4202", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7250", "PWY-7742", "PWY-2681", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-8117", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR022203": {"description": "Protein of unknown function DUF3727", "go_ids": [], "go_terms": [], "name": "DUF3727", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022204": {"description": "Prepilin peptidase dependent protein C-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PpdC-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022205": {"description": "Protein of unknown function DUF3732", "go_ids": [], "go_terms": [], "name": "DUF3732", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022206": {"description": "Firmicutes EssC, N-terminal", "go_ids": [], "go_terms": [], "name": "Firmicutes_EssC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022207": {"description": "Genetic suppressor element-like", "go_ids": [], "go_terms": [], "name": "GSE-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022208": {"description": "Protein of unknown function DUF3737", "go_ids": [], "go_terms": [], "name": "DUF3737", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022209": {"description": "Pre-mRNA splicing factor", "go_ids": [], "go_terms": [], "name": "CWC25", "pathway_ids": ["R-SPO-72163", "R-HSA-9918481", "R-HSA-72163", "R-MMU-72163"], "pathways": ["R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR022210": {"description": "Transcription activator GCR1-like domain", "go_ids": [], "go_terms": [], "name": "TF_GCR1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022211": {"description": "Poly-beta-hydroxybutyrate polymerase N-terminal", "go_ids": [], "go_terms": [], "name": "PHBC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022212": {"description": "Domain of unknown function DUF3741", "go_ids": [], "go_terms": [], "name": "DUF3741", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022213": {"description": "Protein of unknown function DUF3742", "go_ids": [], "go_terms": [], "name": "DUF3742", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022214": {"description": "Mitotic-spindle organizing protein 1", "go_ids": ["GO:0033566", "GO:0000931"], "go_terms": ["GO:0033566:gamma-tubulin complex localization:P", "GO:0000931:gamma-tubulin ring complex:C"], "name": "MZT1", "pathway_ids": ["R-HSA-380320", "R-MMU-380270", "R-DRE-380320", "R-XTR-380270", "R-HSA-380270", "R-XTR-380320", "R-MMU-380320"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes"], "type": "Family"}, "IPR022215": {"description": "SteA-like C-terminal", "go_ids": [], "go_terms": [], "name": "SteA-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022216": {"description": "Putative ABC cobalt transporter", "go_ids": [], "go_terms": [], "name": "ABC_Co_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022217": {"description": "Protease inhibitor I10, marinostatin", "go_ids": [], "go_terms": [], "name": "Prot_inh_I10_marinostatin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022218": {"description": "ToxR activated gene A lipoprotein domain", "go_ids": [], "go_terms": [], "name": "TagA_dom", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR022219": {"description": "Poxvirus I6, C-terminal", "go_ids": [], "go_terms": [], "name": "Poxvirus_I6_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022220": {"description": "Hemolytic toxin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Hemolysin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022221": {"description": "Probable type III restriction-modification enzyme HindVI Mod subunit domain", "go_ids": [], "go_terms": [], "name": "T3MH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022222": {"description": "Protein of unknown function DUF3747", "go_ids": [], "go_terms": [], "name": "DUF3747", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022223": {"description": "Protein of unknown function DUF3748", "go_ids": [], "go_terms": [], "name": "DUF3748", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022224": {"description": "Protein of unknown function DUF3750", "go_ids": [], "go_terms": [], "name": "DUF3750", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022225": {"description": "Phage tail fibre protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Phage_tail_fibre_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022226": {"description": "Domain of unknown function DUF3752", "go_ids": [], "go_terms": [], "name": "DUF3752", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022227": {"description": "Protein of unknown function DUF3754", "go_ids": [], "go_terms": [], "name": "DUF3754", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022228": {"description": "Protein of unknown function DUF3755", "go_ids": [], "go_terms": [], "name": "DUF3755", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022229": {"description": "Tripeptidyl peptidase II, second Ig-like domain", "go_ids": [], "go_terms": [], "name": "TPPII_Ig-like-2", "pathway_ids": ["R-SPO-983168", "R-DME-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-MMU-983168"], "pathways": ["R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR022230": {"description": "Protein of unknown function DUF3756", "go_ids": ["GO:0004252", "GO:0004197", "GO:0016817", "GO:0003968", "GO:0070008"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0004197:cysteine-type endopeptidase activity:F", "GO:0016817:hydrolase activity, acting on acid anhydrides:F", "GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0070008:serine-type exopeptidase activity:F"], "name": "DUF3756", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR022231": {"description": "Protein of unknown function DUF3757", "go_ids": [], "go_terms": [], "name": "DUF3757", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022232": {"description": "Tripeptidyl peptidase II, C-terminal domain, arthropoda", "go_ids": [], "go_terms": [], "name": "TPPII_C_art", "pathway_ids": ["R-DME-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-MMU-983168"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR022233": {"description": "TRAPPC10/Trs130, C-terminal", "go_ids": [], "go_terms": [], "name": "TRAPPC10/Trs130_C", "pathway_ids": ["R-SCE-204005", "R-DDI-204005", "R-SCE-8876198", "R-DDI-8876198", "R-DME-8876198", "R-DME-204005"], "pathways": ["R-SCE-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR022234": {"description": "Virulence factor CipC-like", "go_ids": [], "go_terms": [], "name": "CipC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022235": {"description": "Protein of unknown function DUF3760", "go_ids": [], "go_terms": [], "name": "DUF3760", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022236": {"description": "Domain of unknown function DUF3761", "go_ids": [], "go_terms": [], "name": "DUF3761", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022237": {"description": "L-tryptophan decarboxylase PsiD-like", "go_ids": [], "go_terms": [], "name": "PsiD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022238": {"description": "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal", "go_ids": ["GO:0016435", "GO:0070476"], "go_terms": ["GO:0016435:rRNA (guanine) methyltransferase activity:F", "GO:0070476:rRNA (guanine-N7)-methylation:P"], "name": "Bud23_C", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR022239": {"description": "Domain of unknown function DUF3762", "go_ids": [], "go_terms": [], "name": "DUF3762", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022240": {"description": "Protein of unknown function DUF3764", "go_ids": [], "go_terms": [], "name": "DUF3764", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022241": {"description": "Inactive rhomboid protein 1/2, N-terminal", "go_ids": [], "go_terms": [], "name": "iRhom1_2_N", "pathway_ids": ["R-HSA-9662834"], "pathways": ["R-HSA-9662834:r:CD163 mediating an anti-inflammatory response"], "type": "Domain"}, "IPR022242": {"description": "Transposable element P transposase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "TNP-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022243": {"description": "Protein of unknown function DUF3768", "go_ids": [], "go_terms": [], "name": "DUF3768", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022244": {"description": "Protein of unknown function DUF3769", "go_ids": [], "go_terms": [], "name": "DUF3769", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022245": {"description": "Rubivirus non-structural protein, C-terminal", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "Rubi_NSP_C", "pathway_ids": ["PWY-7342", "PWY-7185", "PWY-7198", "PWY-5381", "PWY-6545", "PWY-2681", "PWY-5316", "PWY-7184", "PWY-7564", "PWY-7210", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-5381:t:NAD salvage (plants)", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Domain"}, "IPR022246": {"description": "Bacteriophage T7, Gp17, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_T7_Gp17_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022247": {"description": "Casein kinase 1 gamma C-terminal", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "Casein_kinase-1_gamma_C", "pathway_ids": ["R-HSA-4641262", "R-HSA-1660661"], "pathways": ["R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Domain"}, "IPR022248": {"description": "TNF receptor family, RELT", "go_ids": [], "go_terms": [], "name": "TNF_rcpt_RELT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022249": {"description": "Domain of unknown function DUF3772", "go_ids": [], "go_terms": [], "name": "DUF3772", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022250": {"description": "Type IVb secretion, IcmS, effector-recruitment", "go_ids": [], "go_terms": [], "name": "T4bSS_IcmS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022251": {"description": "Protein of unknown function wound-induced", "go_ids": [], "go_terms": [], "name": "DUF3774_wound-induced", "pathway_ids": [], "pathways": [], "type": "Family"}, 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{"description": "10TM putative phosphate transporter, extracellular tail", "go_ids": [], "go_terms": [], "name": "PHM7_ext", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022258": {"description": "Flagellar operon protein YvyF", "go_ids": [], "go_terms": [], "name": "Flagellar_operon_YvyF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022259": {"description": "Accessory Sec system protein Asp3", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "Acessory_Sec_prot_Asp3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022260": {"description": "Integrating conjugative element protein PilL, PFGI-1", "go_ids": [], "go_terms": [], "name": "Integr_conj_element_PilL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022261": {"description": "Ribosomal natural product, two-chain TOMM family", "go_ids": [], "go_terms": [], "name": "RNP_Burkhold", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022262": 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silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay 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Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR022310": {"description": "NAD/GMP synthase", "go_ids": [], "go_terms": [], "name": "NAD/GMP_synthase", "pathway_ids": ["PWY-7221", "R-SPO-196807", "R-MMU-9748787", "R-MMU-196807", "R-SCE-9748787", "R-DDI-9748787", "R-SCE-196807", "R-HSA-196807", "R-SCE-73817", "R-MMU-73817", "R-CEL-73817", "R-DDI-196807", "R-PFA-73817", "R-RNO-196807", "R-BTA-196807", "R-DDI-73817", "R-CEL-9748787", "R-HSA-9748787", "R-DME-196807", "R-RNO-73817", 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["GO:0015628", "GO:0015627"], "go_terms": ["GO:0015628:protein secretion by the type II secretion system:P", "GO:0015627:type II protein secretion system complex:C"], "name": "T2SS_GspH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022347": {"description": "G protein-coupled receptor 153/162", "go_ids": ["GO:0004930", "GO:0007186", "GO:0016020"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F", "GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0016020:membrane:C"], "name": "GCR_153/162", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022350": {"description": "Insulin-like growth factor IGF-1/2", "go_ids": ["GO:0005576", "GO:0008083", "GO:0005179"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0008083:growth factor activity:F", "GO:0005179:hormone activity:F"], "name": "IGF-1/2", "pathway_ids": ["R-CFA-381426", "R-RNO-2404192", "R-HSA-2404192", "R-SSC-381426", "R-CFA-2404192", "R-SSC-2428933", "R-RNO-2428933", "R-BTA-2428933", "R-BTA-2428928", "R-SSC-114608", "R-CFA-2428933", "R-HSA-2428933", "R-BTA-2404192", "R-CFA-422085", "R-HSA-422085", "R-MMU-2404192", "R-RNO-114608", "R-CFA-114608", "R-CFA-2428928", "R-MMU-422085", "R-RNO-381426", "R-HSA-114608", "R-BTA-114608", "R-RNO-2428928", "R-BTA-422085", "R-MMU-114608", "R-SSC-2404192", "R-MMU-381426", "R-BTA-381426", "R-MMU-2428928", "R-SSC-2428928", "R-RNO-422085", "R-HSA-2428928", "R-HSA-381426", "R-MMU-2428933"], "pathways": ["R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CFA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-SSC-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-114608:r:Platelet degranulation", "R-CFA-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-RNO-114608:r:Platelet degranulation", "R-CFA-114608:r:Platelet degranulation", "R-CFA-2428928:r:IRS-related events triggered by IGF1R", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-114608:r:Platelet degranulation", "R-SSC-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-2428928:r:IRS-related events triggered by IGF1R", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2428933:r:SHC-related events triggered by IGF1R"], "type": "Family"}, "IPR022359": {"description": "Aminoglycoside phosphotransferase, bacteria", "go_ids": [], "go_terms": [], "name": "Aminoglycoside_PTrfase_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022365": {"description": "Clathrin, heavy chain, propeller repeat", "go_ids": [], "go_terms": [], "name": "Clathrin_H-chain_propeller_rpt", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-SPO-437239", "R-SCE-8856828", "R-DME-190873", "R-BTA-196025", "R-BTA-9013424", "R-HSA-9700645", "R-HSA-8856828", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-9013424", "R-CEL-432722", "R-HSA-9013424", "R-RNO-8964038", "R-BTA-190873", "R-DME-5099900", "R-MMU-9013420", "R-RNO-9013424", "R-RNO-196025", "R-RNO-177504", "R-DDI-8856828", "R-SCE-9013420", "R-DME-3928665", "R-DME-8964038", "R-DDI-8964038", "R-DME-177504", "R-HSA-5140745", "R-RNO-8866427", "R-RNO-432722", "R-MMU-196025", "R-BTA-5099900", "R-RNO-432720", "R-DME-437239", "R-HSA-432720", "R-DME-196025", "R-DME-5140745", "R-HSA-437239", "R-CEL-8866427", "R-BTA-177504", "R-MMU-5140745", "R-SPO-8866427", "R-CEL-8964038", "R-SPO-190873", "R-MMU-8866427", "R-SPO-9013424", "R-SCE-196025", "R-SPO-196025", "R-RNO-9013420", "R-CEL-8856825", "R-SCE-8866427", "R-HSA-2132295", "R-DME-432720", "R-MMU-8856825", "R-HSA-190873", "R-CEL-432720", "R-MMU-432722", "R-CEL-190873", "R-DDI-437239", "R-CEL-437239", "R-DME-8866427", "R-DME-9013424", "R-SPO-8964038", "R-HSA-9725370", "R-MMU-190873", "R-CEL-5140745", "R-SCE-432720", "R-DDI-8866427", "R-RNO-190873", "R-MMU-8964038", "R-HSA-168275", "R-MMU-2132295", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-DME-8856828", "R-SPO-9013420", "R-SCE-9013424", "R-RNO-5099900", "R-SCE-8964038", "R-HSA-432722", "R-SPO-432720", "R-BTA-2132295", "R-MMU-432720", "R-BTA-8856828", "R-HSA-196025", "R-CEL-8856828", "R-BTA-9013420", "R-RNO-2132295", "R-DME-8856825", "R-HSA-9013420", "R-RNO-8856825", "R-MMU-437239", "R-RNO-437239", "R-BTA-432720", "R-CEL-196025", "R-DDI-432720", "R-HSA-5099900", "R-DME-432722", "R-MMU-9013424", "R-SPO-8856828", "R-CEL-3928665", "R-HSA-177504", "R-HSA-8866427", "R-BTA-8856825", "R-BTA-8964038", "R-HSA-8856825", "R-HSA-3928665", "R-SCE-437239", "R-MMU-177504", "R-CEL-9013420", "R-BTA-432722", "R-BTA-5140745", "R-SCE-190873", "R-HSA-8964038", "R-DME-9013420"], "pathways": ["R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-437239:r:Recycling pathway of L1", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-DME-190873:r:Gap junction degradation", "R-BTA-196025:r:Formation of annular gap junctions", "R-BTA-9013424:r:RHOV GTPase cycle", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-9013424:r:RHOV GTPase cycle", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-8964038:r:LDL clearance", "R-BTA-190873:r:Gap junction degradation", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-RNO-196025:r:Formation of annular gap junctions", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-SCE-9013420:r:RHOU GTPase cycle", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-8964038:r:LDL clearance", "R-DDI-8964038:r:LDL clearance", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-196025:r:Formation of annular gap junctions", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-196025:r:Formation of annular gap junctions", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-437239:r:Recycling pathway of L1", "R-CEL-8866427:r:VLDLR internalisation and degradation", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-CEL-8964038:r:LDL clearance", "R-SPO-190873:r:Gap junction degradation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SCE-196025:r:Formation of annular gap junctions", "R-SPO-196025:r:Formation of annular gap junctions", "R-RNO-9013420:r:RHOU GTPase cycle", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-190873:r:Gap junction degradation", "R-DDI-437239:r:Recycling pathway of L1", "R-CEL-437239:r:Recycling pathway of L1", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-DME-9013424:r:RHOV GTPase cycle", "R-SPO-8964038:r:LDL clearance", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-190873:r:Gap junction degradation", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-RNO-190873:r:Gap junction degradation", "R-MMU-8964038:r:LDL clearance", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-437239:r:Recycling pathway of L1", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-SPO-9013420:r:RHOU GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SCE-8964038:r:LDL clearance", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-196025:r:Formation of annular gap junctions", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-CEL-196025:r:Formation of annular gap junctions", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-190873:r:Gap junction degradation", "R-HSA-8964038:r:LDL clearance", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Repeat"}, "IPR022366": {"description": "Pup deamidase", "go_ids": ["GO:0008233", "GO:0016811"], "go_terms": ["GO:0008233:peptidase activity:F", "GO:0016811:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides:F"], "name": "Pup_deamidase", "pathway_ids": ["PWY-7893"], "pathways": ["PWY-7893:t:protein Pupylation and dePupylation"], "type": "Family"}, "IPR022367": {"description": "2-oxoacid:acceptor oxidoreductase, alpha subunit", "go_ids": [], "go_terms": [], "name": "2-oxoacid/accept_OxRdtase_asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022368": {"description": "Putative thiazole-containing bacteriocin maturation protein", "go_ids": [], "go_terms": [], "name": "Thiazole_bacteriocin_mat_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022369": {"description": "Integral membrane protein TerC, riboswitch-linked", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Integral_membrane_TerC_rswitch", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022370": {"description": "Phosphosulpholactate synthase", "go_ids": ["GO:0019295", "GO:0043817"], "go_terms": ["GO:0019295:coenzyme M biosynthetic process:P", "GO:0043817:phosphosulfolactate synthase activity:F"], "name": "Arch_ComA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022371": {"description": "Exopolyphosphatase", "go_ids": ["GO:0006793", "GO:0004309"], "go_terms": ["GO:0006793:phosphorus metabolic process:P", "GO:0004309:exopolyphosphatase activity:F"], "name": "Exopolyphosphatase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022372": {"description": "Accessory secretory system protein Asp1", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "Accessory_SS_Asp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022373": {"description": "KaiC domain-containing protein", "go_ids": [], "go_terms": [], "name": "KaiC_containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022374": {"description": "Energy-dependent translational throttle protein EttA", "go_ids": ["GO:0045900"], "go_terms": ["GO:0045900:negative regulation of translational elongation:P"], "name": "EttA", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR022376": {"description": "PQQ-dependent catabolism-associated CXXCW motif", "go_ids": [], "go_terms": [], "name": "PQQ_CXXCW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022378": {"description": "F420-dependent oxidoreductase-predicted, MSMEG2249", "go_ids": [], "go_terms": [], "name": "F420_OxRdatse_MSMEG2249_pred", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022380": {"description": "Glutamyl-Q tRNA(Asp) synthetase", "go_ids": ["GO:0004812", "GO:0006400", "GO:0000166", "GO:0008270", "GO:0006424"], "go_terms": ["GO:0004812:aminoacyl-tRNA ligase activity:F", "GO:0006400:tRNA modification:P", "GO:0000166:nucleotide binding:F", "GO:0008270:zinc ion binding:F", "GO:0006424:glutamyl-tRNA aminoacylation:P"], "name": "Glu-Q_tRNA(Asp)_Synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022382": {"description": "Mycoplasma immunoglobulin protease", "go_ids": [], "go_terms": [], "name": "MIP_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022383": {"description": "Lactate/malate dehydrogenase, C-terminal", "go_ids": ["GO:0016616"], "go_terms": ["GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "Lactate/malate_DH_C", "pathway_ids": ["PWY-7383", "PWY-8086", "PWY-1622", "PWY-6728", "PWY-7115", "PWY-561", "PWY-5690", "PWY-5392", "PWY-6969", "R-MMU-9837999", "R-HSA-9856872", "R-MMU-9861718", "R-XTR-9856872", "R-HSA-9861718", "R-DDI-9856872", "R-RNO-70268", "R-SPO-71403", "R-CEL-71403", "R-MMU-71403", "R-BTA-9837999", "R-GGA-373920", "R-GGA-70268", "R-HSA-9837999", "R-RNO-71403", "R-SPO-9856872", "R-BTA-9856872", "R-HSA-71403", "R-MMU-70268", "R-DRE-9861718", "R-CEL-9837999", "R-BTA-71403", "R-BTA-9861718", "R-RNO-9837999", "R-GGA-352875", "R-DME-9861718", "R-CEL-9856872", "R-HSA-70268", "R-BTA-70268", "R-SCE-9856872", "R-DME-70268", "R-CEL-70268", "R-DRE-70268", "R-SPO-9837999", "R-SSC-9856872", "R-SCE-71403", "R-SCE-9837999", "R-MMU-9856872", "R-RNO-9856872", "R-RNO-9861718"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-6728:t:methylaspartate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-9856872:r:Malate-aspartate shuttle", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-XTR-9856872:r:Malate-aspartate shuttle", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-DDI-9856872:r:Malate-aspartate shuttle", "R-RNO-70268:r:Pyruvate metabolism", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-GGA-373920:r:Pyruvate metabolism", "R-GGA-70268:r:Pyruvate metabolism", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-9856872:r:Malate-aspartate shuttle", "R-BTA-9856872:r:Malate-aspartate shuttle", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-70268:r:Pyruvate metabolism", "R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-GGA-352875:r:Gluconeogenesis", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-SCE-9856872:r:Malate-aspartate shuttle", "R-DME-70268:r:Pyruvate metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-DRE-70268:r:Pyruvate metabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SSC-9856872:r:Malate-aspartate shuttle", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-RNO-9861718:r:Regulation of pyruvate metabolism"], "type": "Domain"}, "IPR022384": {"description": "Formiminotransferase catalytic domain superfamily", "go_ids": ["GO:0016740", "GO:0005542"], "go_terms": ["GO:0016740:transferase activity:F", "GO:0005542:folic acid binding:F"], "name": "FormiminoTrfase_cat_dom_sf", "pathway_ids": ["PWY-5030", "R-MMU-70921", "R-RNO-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Homologous_superfamily"}, "IPR022385": {"description": "Rhs repeat-associated core", "go_ids": [], "go_terms": [], "name": "Rhs_assc_core", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022386": {"description": "Carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein", "go_ids": [], "go_terms": [], "name": "Chitin_NgcE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022387": {"description": "Carbohydrate ABC transporter substrate-binding, CPR0540", "go_ids": [], "go_terms": [], "name": "Bind_CPR0540", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022388": {"description": "Conserved hypothetical protein CHP03808", "go_ids": [], "go_terms": [], "name": "CHP03808", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022389": {"description": "ParB-related, ThiF-related cassette, protein D", "go_ids": [], "go_terms": [], "name": "PRTRC_protein-D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022390": {"description": "4-hydroxybenzoate decarboxylase subunit C", "go_ids": ["GO:0016831"], "go_terms": ["GO:0016831:carboxy-lyase activity:F"], "name": "HBDC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022391": {"description": "Integrating conjugative element relaxase, PFGI-1 class", "go_ids": [], "go_terms": [], "name": "ICE_relaxase_PFGI-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022392": {"description": "Anchored repeat-type ABC transporter, permease subunit", "go_ids": [], "go_terms": [], "name": "Anch_rpt-typ_ABC_trnsprt_perm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022393": {"description": "Conjugative transposon, TraJ", "go_ids": [], "go_terms": [], "name": "Conjugative_transposon_TraJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022394": {"description": "Methylamine utilisation protein, MauG", "go_ids": ["GO:0020037", "GO:0030416", "GO:0016491", "GO:0005509"], "go_terms": ["GO:0020037:heme binding:F", "GO:0030416:methylamine metabolic process:P", "GO:0016491:oxidoreductase activity:F", "GO:0005509:calcium ion binding:F"], "name": "Methylamine_utilis_MauG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022395": {"description": "Conserved hypothetical protein CHP03773, ABC transporter-like", "go_ids": [], "go_terms": [], "name": "CHP03773_ABC_transptr-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022396": {"description": "ParB-related, ThiF-related cassette, ParB", "go_ids": [], "go_terms": [], "name": "PRTRC_ParB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022397": {"description": "Tyrosine decarboxylase, bacteria", "go_ids": [], "go_terms": [], "name": "Tyrosine_deCO2ase_bac", "pathway_ids": ["PWY-5870", "PWY-6309", "PWY-5871", "PWY-7007", "PWY-6322", "PWY-6055", "PWY-8037", "PWY-7769", "PWY-7557", "PWY-7826", "PWY-6262", "PWY-6133", "PWY-6627", "PWY-8376", "PWY-5163", "PWY-3581", "PWY-6340", "PWY-5956", "PWY-5873", "PWY-7154", "PWY-5254", "PWY-7620", "PWY-3542", "PWY-6633", "PWY-7230", "PWY-6959", "PWY-7931", "PWY-7352", "PWY-5474", "PWY-5113", "PWY-7372", "PWY-5872", "PWY-7782", "PWY-7690", "PWY-8158", "PWY-5826", "PWY-7419", "PWY-6935", "PWY-7297", "PWY-8166", "PWY-6802", "PWY-7742", "PWY-3385", "PWY-7480", "PWY-7741", "PWY-8387", "PWY-8085", "PWY-5706", "PWY-8358"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6055:t:dimethylsulfoniopropanoate biosynthesis II (Spartina)", "PWY-8037:t:saliniketal A biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-6133:t:(S)-reticuline biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8376:t:benzene degradation III (anaerobic)", "PWY-5163:t:p-cumate degradation to 2-hydroxypentadienoate", "PWY-3581:t:(S)-reticuline biosynthesis I", "PWY-6340:t:5,5'-dehydrodivanillate degradation", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-7154:t:ergosterol biosynthesis II", "PWY-5254:t:methanofuran biosynthesis", "PWY-7620:t:naphthalene degradation (anaerobic)", "PWY-3542:t:choline biosynthesis II", "PWY-6633:t:caffeine degradation V (bacteria, via trimethylurate)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-6959:t:L-ascorbate degradation V", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-5474:t:hydroxycinnamic acid tyramine amides biosynthesis", "PWY-5113:t:UDP-D-apiose biosynthesis (from UDP-D-glucuronate)", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7690:t:holomycin biosynthesis", "PWY-8158:t:ibotenate and muscimol biosynthesis", "PWY-5826:t:hypoglycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6935:t:seleno-amino acid detoxification and volatilization II", "PWY-7297:t:octopamine biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-3385:t:choline biosynthesis I", "PWY-7480:t:2,3-dihydroxybenzoate degradation", "PWY-7741:t:phthiocerol biosynthesis", "PWY-8387:t:microcin C biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-5706:t:alliin metabolism", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR022399": {"description": "TadA-like conjugal transfer-associated ATPase", "go_ids": [], "go_terms": [], "name": "TadA-like_ATPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022400": {"description": "Adhesin P1", "go_ids": [], "go_terms": [], "name": "Adhesin_P1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022401": {"description": "Cysteate synthase", "go_ids": ["GO:0016765"], "go_terms": ["GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "Cysteate_synthase", "pathway_ids": ["PWY-6643"], "pathways": ["PWY-6643:t:coenzyme M biosynthesis II"], "type": "Family"}, "IPR022402": {"description": "F420-dependent oxidoreductase-predicted, MSMEG3544", "go_ids": [], "go_terms": [], "name": "F420_OxRdatse_MSMEG3544_pred", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022403": {"description": "Alcohol ABC transporter, permease protein", "go_ids": [], "go_terms": [], "name": "Alc_ABC_transptr_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022404": {"description": "Diphtheria toxin, receptor-binding domain", "go_ids": [], "go_terms": [], "name": "Diphtheria_toxin_rcpt-bd_dom", "pathway_ids": ["R-HSA-5336415"], "pathways": ["R-HSA-5336415:r:Uptake and function of diphtheria toxin"], "type": "Domain"}, "IPR022406": {"description": "Diphtheria toxin, catalytic domain", "go_ids": [], "go_terms": [], "name": "Diphtheria_toxin_catalytic_dom", "pathway_ids": ["R-HSA-5336415"], "pathways": ["R-HSA-5336415:r:Uptake and function of diphtheria toxin"], "type": "Domain"}, "IPR022409": {"description": "PKD/Chitinase domain", "go_ids": [], "go_terms": [], "name": "PKD/Chitinase_dom", "pathway_ids": ["R-MMU-8856828", "R-HSA-5620916", "R-MMU-5620916", "R-RNO-8856825", "R-MMU-8857538", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-RNO-8856828", "R-RNO-8857538", "R-HSA-9824585", "R-HSA-8857538"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Domain"}, "IPR022410": {"description": "ABC transporter, permease F420-0", "go_ids": [], "go_terms": [], "name": "ABC_transptr_permease_F420-0", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022411": {"description": "C-type cytochrome, methanol metabolism-related", "go_ids": [], "go_terms": [], "name": "C-typ_cyt_methanol_metab-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022412": {"description": "Quinolinate phosphoribosyl transferase, N-terminal", "go_ids": ["GO:0016763"], "go_terms": ["GO:0016763:pentosyltransferase activity:F"], "name": "Quinolinate_PRibosylTrfase_N", "pathway_ids": ["PWY-7342", "PWY-8277", "PWY-5653", "PWY-5316", "PWY-8352", "R-MMU-196807", "R-HSA-196807", "R-DDI-196807", "R-RNO-196807", "R-SSC-196807", "R-SCE-196807"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-8277:t:NAD de novo biosynthesis IV (anaerobic)", "PWY-5653:t:NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde", "PWY-5316:t:nicotine biosynthesis", "PWY-8352:t:NAD de novo biosynthesis III", "R-MMU-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-SSC-196807:r:Nicotinate metabolism", "R-SCE-196807:r:Nicotinate metabolism"], "type": "Domain"}, "IPR022413": {"description": "ATP:guanido phosphotransferase, N-terminal", "go_ids": ["GO:0016301", "GO:0016772"], "go_terms": ["GO:0016301:kinase activity:F", "GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "ATP-guanido_PTrfase_N", "pathway_ids": ["R-CFA-9696264", "R-MMU-71288", "R-HSA-71288", "R-BTA-9696264", "R-RNO-71288", "R-SSC-71288", "R-RNO-9696264", "R-CFA-71288", "R-MMU-9696264", "R-BTA-71288", "R-GGA-71288", "R-HSA-9696264", "R-GGA-9696264"], "pathways": ["R-CFA-9696264:r:RND3 GTPase cycle", "R-MMU-71288:r:Creatine metabolism", "R-HSA-71288:r:Creatine metabolism", "R-BTA-9696264:r:RND3 GTPase cycle", "R-RNO-71288:r:Creatine metabolism", "R-SSC-71288:r:Creatine metabolism", "R-RNO-9696264:r:RND3 GTPase cycle", "R-CFA-71288:r:Creatine metabolism", "R-MMU-9696264:r:RND3 GTPase cycle", "R-BTA-71288:r:Creatine metabolism", "R-GGA-71288:r:Creatine metabolism", "R-HSA-9696264:r:RND3 GTPase cycle", "R-GGA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR022414": {"description": "ATP:guanido phosphotransferase, catalytic domain", "go_ids": ["GO:0016301", "GO:0016772"], "go_terms": ["GO:0016301:kinase activity:F", "GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "ATP-guanido_PTrfase_cat", "pathway_ids": ["R-CFA-9696264", "R-MMU-71288", "R-HSA-71288", "R-BTA-9696264", "R-RNO-71288", "R-SSC-71288", "R-RNO-9696264", "R-CFA-71288", "R-MMU-9696264", "R-BTA-71288", "R-GGA-71288", "R-HSA-9696264", "R-GGA-9696264"], "pathways": ["R-CFA-9696264:r:RND3 GTPase cycle", "R-MMU-71288:r:Creatine metabolism", "R-HSA-71288:r:Creatine metabolism", "R-BTA-9696264:r:RND3 GTPase cycle", "R-RNO-71288:r:Creatine metabolism", "R-SSC-71288:r:Creatine metabolism", "R-RNO-9696264:r:RND3 GTPase cycle", "R-CFA-71288:r:Creatine metabolism", "R-MMU-9696264:r:RND3 GTPase cycle", "R-BTA-71288:r:Creatine metabolism", "R-GGA-71288:r:Creatine metabolism", "R-HSA-9696264:r:RND3 GTPase cycle", "R-GGA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR022416": {"description": "Prion/Doppel protein, beta-ribbon domain", "go_ids": ["GO:0051260", "GO:0016020"], "go_terms": ["GO:0051260:protein homooligomerization:P", "GO:0016020:membrane:C"], "name": "Prion/Doppel_prot_b-ribbon_dom", "pathway_ids": ["R-MMU-9609523", "R-MMU-163125", "R-HSA-9609523", "R-RNO-9609523", "R-GGA-163125", "R-HSA-419037", "R-HSA-163125", "R-GGA-9609523"], "pathways": ["R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-GGA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Domain"}, "IPR022417": {"description": "Porphobilinogen deaminase, N-terminal", "go_ids": ["GO:0033014", "GO:0004418"], "go_terms": ["GO:0033014:tetrapyrrole biosynthetic process:P", "GO:0004418:hydroxymethylbilane synthase activity:F"], "name": "Porphobilin_deaminase_N", "pathway_ids": ["PWY-5188", "PWY-5189", "R-RNO-189451", "R-BTA-189451", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "PWY-5189:t:tetrapyrrole biosynthesis II (from glycine)", "R-RNO-189451:r:Heme biosynthesis", "R-BTA-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Domain"}, "IPR022418": {"description": "Porphobilinogen deaminase, C-terminal", "go_ids": ["GO:0033014", "GO:0004418"], "go_terms": ["GO:0033014:tetrapyrrole biosynthetic process:P", "GO:0004418:hydroxymethylbilane synthase activity:F"], "name": "Porphobilinogen_deaminase_C", "pathway_ids": ["PWY-5188", "PWY-5189", "R-RNO-189451", "R-BTA-189451", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "PWY-5189:t:tetrapyrrole biosynthesis II (from glycine)", "R-RNO-189451:r:Heme biosynthesis", "R-BTA-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Domain"}, "IPR022420": {"description": "Circadian clock protein, KaiC, methanobacteria", "go_ids": [], "go_terms": [], "name": "Circ_KaiC_methanobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022423": {"description": "Neurohypophysial hormone, conserved site", "go_ids": ["GO:0005185", "GO:0005576"], "go_terms": ["GO:0005185:neurohypophyseal hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Neurohypophysial_hormone_CS", "pathway_ids": ["R-RNO-8856828", "R-RNO-432040", "R-DRE-416476", "R-HSA-9036092", "R-RNO-416476", "R-DRE-432040", "R-MMU-418555", "R-HSA-5619099", "R-DRE-8856825", "R-MMU-416476", "R-MMU-8856828", "R-HSA-879518", "R-SSC-432040", "R-RNO-8856825", "R-MMU-8856825", "R-RNO-388479", "R-HSA-8856828", "R-SSC-388479", "R-HSA-418555", "R-HSA-416476", "R-SSC-879518", "R-RNO-879518", "R-HSA-388479", "R-HSA-1368108", "R-SSC-416476", "R-MMU-432040", "R-BTA-416476", "R-BTA-388479", "R-MMU-388479", "R-MMU-879518", "R-SSC-8856828", "R-HSA-432040", "R-DRE-388479", "R-HSA-8856825", "R-DRE-879518", "R-SSC-8856825"], "pathways": ["R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-416476:r:G alpha (q) signalling events", "R-HSA-9036092:r:Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)", "R-RNO-416476:r:G alpha (q) signalling events", "R-DRE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-5619099:r:Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-879518:r:Organic anion transport by SLCO transporters", "R-SSC-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-388479:r:Vasopressin-like receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-388479:r:Vasopressin-like receptors", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-416476:r:G alpha (q) signalling events", "R-SSC-879518:r:Organic anion transport by SLCO transporters", "R-RNO-879518:r:Organic anion transport by SLCO transporters", "R-HSA-388479:r:Vasopressin-like receptors", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-SSC-416476:r:G alpha (q) signalling events", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-416476:r:G alpha (q) signalling events", "R-BTA-388479:r:Vasopressin-like receptors", "R-MMU-388479:r:Vasopressin-like receptors", "R-MMU-879518:r:Organic anion transport by SLCO transporters", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-388479:r:Vasopressin-like receptors", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-879518:r:Organic anion transport by SLCO transporters", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis"], "type": "Conserved_site"}, "IPR022424": {"description": "Translation initiation factor 2, gamma subunit", "go_ids": [], "go_terms": [], "name": "TIF2_gsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022425": {"description": "Flagellar export ATPase FliI, clade 2", "go_ids": ["GO:0044780", "GO:0071973", "GO:0016887"], "go_terms": ["GO:0044780:bacterial-type flagellum assembly:P", "GO:0071973:bacterial-type flagellum-dependent cell motility:P", "GO:0016887:ATP hydrolysis activity:F"], "name": "FliI_clade2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022426": {"description": "Flagellum-specific ATP synthase FliI, clade 3", "go_ids": ["GO:0016887", "GO:0030257", "GO:0044781", "GO:0009288"], "go_terms": ["GO:0016887:ATP hydrolysis activity:F", "GO:0030257:type III protein secretion system complex:C", "GO:0044781:bacterial-type flagellum organization:P", "GO:0009288:bacterial-type flagellum:C"], "name": "FliI_clade3", "pathway_ids": ["PWY-7980"], "pathways": ["PWY-7980:t:ATP biosynthesis"], "type": "Family"}, "IPR022427": {"description": "Uncharacterised protein MJ0570, ATP-binding", "go_ids": [], "go_terms": [], "name": "MJ0570_ATP-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022428": {"description": "Diphthamide synthesis Dph2, archaea", "go_ids": ["GO:0017183"], "go_terms": ["GO:0017183:protein histidyl modification to diphthamide:P"], "name": "Dph2_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022429": {"description": "Alanine-tRNA ligase, archaea", "go_ids": ["GO:0000166", "GO:0005737", "GO:0006419"], "go_terms": ["GO:0000166:nucleotide binding:F", "GO:0005737:cytoplasm:C", "GO:0006419:alanyl-tRNA aminoacylation:P"], "name": "Ala-tRNA_lgiase_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022430": {"description": "Conserved hypothetical protein CHP03684", "go_ids": [], "go_terms": [], "name": "CHP03684", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022431": {"description": "Cyclic dehypoxanthine futalosine synthase", "go_ids": ["GO:0009234"], "go_terms": ["GO:0009234:menaquinone biosynthetic process:P"], "name": "Cyclic_DHFL_synthase_mqnC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022432": {"description": "Aminodeoxyfutalosine synthase", "go_ids": ["GO:0009234"], "go_terms": ["GO:0009234:menaquinone biosynthetic process:P"], "name": "MqnE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022433": {"description": "Lipid kinase YegS", "go_ids": ["GO:0001727", "GO:0046872"], "go_terms": ["GO:0001727:lipid kinase activity:F", "GO:0046872:metal ion binding:F"], "name": "Lip_kinase_YegS", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR022434": {"description": "ABC transporter, LPXTG-anchor lipoprotein, actinobacteria", "go_ids": [], "go_terms": [], "name": "ABC_LPXTG_lipo_actinobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022435": {"description": "Surface-anchored repeat, actinobacteria", "go_ids": [], "go_terms": [], "name": "Surface-anchored_actinobac", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR022436": {"description": "Rickettsia palindromic element RPE2", "go_ids": [], "go_terms": [], "name": "RPE2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022437": {"description": "Rickettsia palindromic element RPE3", "go_ids": [], "go_terms": [], "name": "RPE3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022438": {"description": "Rickettsia palindromic element 5", "go_ids": [], "go_terms": [], "name": "RPE5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022439": {"description": "Rickettsia palindromic element RPE4", "go_ids": [], "go_terms": [], "name": "RPE4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022440": {"description": "Conserved hypothetical protein CHP03788", "go_ids": [], "go_terms": [], "name": "CHP03788", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022441": {"description": "Parallel beta-helix repeat-2", "go_ids": [], "go_terms": [], "name": "Para_beta_helix_rpt-2", "pathway_ids": ["R-MMU-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-CEL-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation"], "type": "Repeat"}, "IPR022442": {"description": "SO_2930-like, beta-helix domain", "go_ids": [], "go_terms": [], "name": "SO_2930-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022443": {"description": "Circadian clock protein, KaiC, thermoprotea", "go_ids": [], "go_terms": [], "name": "KaiC_thermoprot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022444": {"description": "Cofactor-binding repeat, putative", "go_ids": [], "go_terms": [], "name": "Cofactor-bd_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR022445": {"description": "Sortase, proteobacterial type", "go_ids": [], "go_terms": [], "name": "Sortase_proteobact_type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022446": {"description": "N5-glutamine methyltransferase, putative", "go_ids": [], "go_terms": [], "name": "MeTrfrase_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022447": {"description": "Lysine-2,3-aminomutase-related", "go_ids": [], "go_terms": [], "name": "Lys_aminomutase-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022448": {"description": "Quinoprotein dehydrogenase-associated", "go_ids": [], "go_terms": [], "name": "Quinoprotein_dehydrogenase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022450": {"description": "tRNA N6-adenosine threonylcarbamoyltransferase, TsaD", "go_ids": ["GO:0002949"], "go_terms": ["GO:0002949:tRNA threonylcarbamoyladenosine modification:P"], "name": "TsaD", "pathway_ids": ["R-HSA-6787450"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Family"}, "IPR022451": {"description": "Conserved hypothetical protein CHP03829, YokU", "go_ids": [], "go_terms": [], "name": "CHP03829_YokU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022452": {"description": "Antitoxin MqsA", "go_ids": [], "go_terms": [], "name": "MqsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022453": {"description": "Zinc finger, MqsA-type", "go_ids": [], "go_terms": [], "name": "Znf_MqsA-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022454": {"description": "Conserved hypothetical protein CHP03883, F420 biosynthesis associated", "go_ids": [], "go_terms": [], "name": "CHP03883_F420-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022455": {"description": "Methanol oxidation system protein MoxJ", "go_ids": ["GO:0042597", "GO:0046170"], "go_terms": ["GO:0042597:periplasmic space:C", "GO:0046170:methanol catabolic process:P"], "name": "Methanol_oxidation_MoxJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022456": {"description": "PQQ-dependent catabolism-associated beta-propeller protein", "go_ids": [], "go_terms": [], "name": "PQQ_b_propeller", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022457": {"description": "Aspartate-alanine antiporter", "go_ids": ["GO:0022857", "GO:0016020"], "go_terms": ["GO:0022857:transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "Asp_Ala_antiprt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022458": {"description": "Conjugative coupling factor TraG/TraD", "go_ids": [], "go_terms": [], "name": "Conjugative_coupling_TraG/TraD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022459": {"description": "Lysine-2,3-aminomutase", "go_ids": [], "go_terms": [], "name": "Lysine_aminomutase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022460": {"description": "Conserved hyptotheical flavoprotein, PP4765", "go_ids": [], "go_terms": [], "name": "Flavoprotein_PP4765", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022461": {"description": "Arginine/ornithine antiporter", "go_ids": ["GO:0006527", "GO:0005886", "GO:0043858", "GO:1903826"], "go_terms": ["GO:0006527:L-arginine catabolic process:P", "GO:0005886:plasma membrane:C", "GO:0043858:arginine:ornithine antiporter activity:F", "GO:1903826:L-arginine transmembrane transport:P"], "name": "Arg/Orn_antiprt_ArcD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022462": {"description": "Lysine-2,3-aminomutase-like", "go_ids": [], "go_terms": [], "name": "EpmB", "pathway_ids": ["PWY-7570"], "pathways": ["PWY-7570:t:blasticidin S biosynthesis"], "type": "Family"}, "IPR022463": {"description": "Fructose 1-phosphate kinase", "go_ids": ["GO:0008662"], "go_terms": ["GO:0008662:1-phosphofructokinase activity:F"], "name": "1-PFruKinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022464": {"description": "Streptococcal pilin isopeptide linkage domain", "go_ids": [], "go_terms": [], "name": "Strep_pil_isopept_link", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022465": {"description": "Terminal organelle assembly protein TopJ", "go_ids": [], "go_terms": [], "name": "Termin_org_TopJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022466": {"description": "Enriched in aromatic and glycine residues box", "go_ids": [], "go_terms": [], "name": "EAGR_box", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022467": {"description": "ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system", "go_ids": [], "go_terms": [], "name": "ABC_transprt_ATP-bd_su_PQQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022468": {"description": "Phosphonatase-like hydrolase", "go_ids": [], "go_terms": [], "name": "PhnX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022471": {"description": "Cysteine desulphurase, catalytic subunit, CsdA", "go_ids": ["GO:0016226", "GO:0031071"], "go_terms": ["GO:0016226:iron-sulfur cluster assembly:P", "GO:0031071:cysteine desulfurase activity:F"], "name": "Cys_desulphurase_CdsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022472": {"description": "VPLPA-CTERM sorting domain", "go_ids": [], "go_terms": [], "name": "VPLPA-CTERM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022473": {"description": "ABC transporter, Choline, ATP-binding subunit", "go_ids": ["GO:0015220", "GO:0015871", "GO:0055052"], "go_terms": ["GO:0015220:choline transmembrane transporter activity:F", "GO:0015871:choline transport:P", "GO:0055052:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing:C"], "name": "ABC_trnsptr_Choline_ATP-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022474": {"description": "Thiopurine S-methyltransferase, Se/Te detoxification", "go_ids": ["GO:0008119", "GO:0032259", "GO:0010038"], "go_terms": ["GO:0008119:thiopurine S-methyltransferase activity:F", "GO:0032259:methylation:P", "GO:0010038:response to metal ion:P"], "name": "Thiopur_S-MeTfrase_Se/Te_detox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022475": {"description": "Uncharacterised protein family UPF0273, KaiC-like", "go_ids": [], "go_terms": [], "name": "UPF0273_KaiC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022476": {"description": "Spore protein YabP/YqfC", "go_ids": [], "go_terms": [], "name": "Spore_YabP/YqfC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022477": {"description": "Sporulation protein YqfC", "go_ids": [], "go_terms": [], "name": "Spore_YqfC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022478": {"description": "ABC transporter, substrate-binding protein, PQQ-dependent alcohol dehydrogenase system", "go_ids": [], "go_terms": [], "name": "ABC_transptr_sub-bd_PQQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022479": {"description": "Coenzyme PQQ synthesis D, bacteria", "go_ids": ["GO:0018189", "GO:0048038"], "go_terms": ["GO:0018189:pyrroloquinoline quinone biosynthetic process:P", "GO:0048038:quinone binding:F"], "name": "PqqD_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022480": {"description": "F420-dependent oxidoreductase, MSMEG2906", "go_ids": [], "go_terms": [], "name": "F420_MSMEG2906", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022481": {"description": "Large ribosomal subunit protein eL8, archaea", "go_ids": ["GO:0006412", "GO:0003735", "GO:0005840", "GO:0003723"], "go_terms": ["GO:0006412:translation:P", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0003723:RNA binding:F"], "name": "Ribosomal_eL8_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022482": {"description": "Proteasome ATPase", "go_ids": ["GO:0000502", "GO:0010498", "GO:0016887", "GO:0019941"], "go_terms": ["GO:0000502:proteasome complex:C", "GO:0010498:proteasomal protein catabolic process:P", "GO:0016887:ATP hydrolysis activity:F", "GO:0019941:modification-dependent protein catabolic process:P"], "name": "Proteasome_ATPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022483": {"description": "Proteasome subunit beta, actinobacteria", "go_ids": ["GO:0004298", "GO:0005839", "GO:0010498"], "go_terms": ["GO:0004298:threonine-type endopeptidase activity:F", "GO:0005839:proteasome core complex:C", "GO:0010498:proteasomal protein catabolic process:P"], "name": "PSB_actinobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022484": {"description": "PEP-CTERM/exosortase system-associated acyltransferase, predicted", "go_ids": [], "go_terms": [], "name": "PEP-CTERM/exosrtase_acylTfrase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022485": {"description": "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase", "go_ids": ["GO:0009234", "GO:0070205"], "go_terms": ["GO:0009234:menaquinone biosynthetic process:P", "GO:0070205:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity:F"], "name": "SHCHC_synthase_MenH", "pathway_ids": ["PWY-5837"], "pathways": ["PWY-5837:t:2-carboxy-1,4-naphthoquinol biosynthesis"], "type": "Family"}, "IPR022486": {"description": "Polyphosphate kinase 2, PA0141", "go_ids": ["GO:0006793", "GO:0008976"], "go_terms": ["GO:0006793:phosphorus metabolic process:P", "GO:0008976:polyphosphate kinase activity:F"], "name": "PPK2_PA0141", "pathway_ids": ["PWY-7039", "PWY-5107"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-5107:t:phytol salvage pathway"], "type": "Family"}, "IPR022487": {"description": "L-aspartate dehydrogenase, archaeal", "go_ids": ["GO:0033735"], "go_terms": ["GO:0033735:L-aspartate dehydrogenase [NAD(P)+] activity:F"], "name": "Asp_DH_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022488": {"description": "Polyphosphate kinase-2-related", "go_ids": [], "go_terms": [], "name": "PPK2-related", "pathway_ids": ["PWY-7039", "PWY-5107"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-5107:t:phytol salvage pathway"], "type": "Domain"}, "IPR022489": {"description": "Polyphosphate:AMP phosphotransferase", "go_ids": ["GO:0006797", "GO:0043751"], "go_terms": ["GO:0006797:polyphosphate metabolic process:P", "GO:0043751:polyphosphate:AMP phosphotransferase activity:F"], "name": "PolyP_AMP_Tfrase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022490": {"description": "Protein translocase subunit SecA2", "go_ids": ["GO:0015031", "GO:0015450"], "go_terms": ["GO:0015031:protein transport:P", "GO:0015450:protein-transporting ATPase activity:F"], "name": "SecA2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022492": {"description": "Phosphomutase MSMEG4193, putative", "go_ids": [], "go_terms": [], "name": "Phosphomutase_MSMEG4193_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022493": {"description": "Integral membrane YkoY", "go_ids": [], "go_terms": [], "name": "CHP03716_TM_YkoY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022494": {"description": "Sulfopyruvate decarboxylase, beta subunit", "go_ids": ["GO:0003824", "GO:0030976"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0030976:thiamine pyrophosphate binding:F"], "name": "Sulfopyruvate_deCO2ase_bsu", "pathway_ids": ["PWY-6637", "PWY-6643"], "pathways": ["PWY-6637:t:sulfolactate degradation II", "PWY-6643:t:coenzyme M biosynthesis II"], "type": "Domain"}, "IPR022495": {"description": "Serine/threonine-protein kinase Bud32", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "Bud32", "pathway_ids": ["R-HSA-6782315", "R-MMU-6804756", "R-HSA-6804756"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation"], "type": "Family"}, "IPR022496": {"description": "tRNA threonylcarbamoyl adenosine modification protein TsaB", "go_ids": ["GO:0002949"], "go_terms": ["GO:0002949:tRNA threonylcarbamoyladenosine modification:P"], "name": "T6A_TsaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022497": {"description": "ABC transporter, urea permease, UrtC", "go_ids": [], "go_terms": [], "name": "ABC_trnspt_urea_permease_UrtC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022498": {"description": "Tungstate ABC transporter, substrate-binding protein WtpA", "go_ids": ["GO:1901359"], "go_terms": ["GO:1901359:tungstate binding:F"], "name": "ABC_trnspt_W-bd_WtpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022499": {"description": "ParB-related, ThiF-related cassette, protein A", "go_ids": [], "go_terms": [], "name": "PRTRC_protein-A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022500": {"description": "ParB-related, ThiF-related cassette, ThiF", "go_ids": [], "go_terms": [], "name": "PRTRC_ThiF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022501": {"description": "Gallidermin ABC transporter, ATP-binding subunit", "go_ids": [], "go_terms": [], "name": "ABC_Gallidermin_ATP-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022502": {"description": "Sulfopyruvate decarboxylase, alpha subunit", "go_ids": ["GO:0030976", "GO:0050545"], "go_terms": ["GO:0030976:thiamine pyrophosphate binding:F", "GO:0050545:sulfopyruvate decarboxylase activity:F"], "name": "Sulfopyruvate_deCO2ase_alpha", "pathway_ids": ["PWY-6637", "PWY-6643"], "pathways": ["PWY-6637:t:sulfolactate degradation II", "PWY-6643:t:coenzyme M biosynthesis II"], "type": "Domain"}, "IPR022503": {"description": "Conjugative coupling factor TraG/TraD, PFGI-1", "go_ids": [], "go_terms": [], "name": "Conj_coupling_TraG/TraD_PFGI-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022504": {"description": "Exosortase, archaea", "go_ids": [], "go_terms": [], "name": "Exosortase_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022505": {"description": "Exosortase, cyanobacteria", "go_ids": [], "go_terms": [], "name": "Exosortase_cyanobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022506": {"description": "Metallophosphoesterase, PPA1498", "go_ids": [], "go_terms": [], "name": "Metallophosphoesterase_PPA1498", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022507": {"description": "Metallophosphoesterase, RPA4764", "go_ids": [], "go_terms": [], "name": "Metallophosphoesterase_RPA4764", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022508": {"description": "ABC transporter, anchored repeat-type, ATP-binding subunit", "go_ids": [], "go_terms": [], "name": "ABC_trspt_anch-rpt_ATP-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022509": {"description": "Conjugation system ATPase, TraG", "go_ids": [], "go_terms": [], "name": "Conjugation_ATPase_TraG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022510": {"description": "Sortase system, histidine kinase", "go_ids": [], "go_terms": [], "name": "Sortase_His-kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022511": {"description": "Proteobacterial sortase system peptidoglycan-associated protein", "go_ids": [], "go_terms": [], "name": "PdsO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022512": {"description": "Conserved hypothetical protein CHP03792", "go_ids": [], "go_terms": [], "name": "CHP03792", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022513": {"description": "NHLP leader peptide domain", "go_ids": [], "go_terms": [], "name": "TOMM_pelo", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022514": {"description": "NHPM bacteriocin system ABC transporter, peptidase/ATP-binding protein", "go_ids": [], "go_terms": [], "name": "NHPM_micro_ABC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022515": {"description": "NHPM bacteriocin system ABC transporter, ATP-binding protein", "go_ids": [], "go_terms": [], "name": "NHPM_micro_ABC2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022516": {"description": "Nif11-like leader peptide", "go_ids": [], "go_terms": [], "name": "CHP03798_Ocin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022517": {"description": "Aspartate 1-decarboxylase, pyridoxal-dependent", "go_ids": [], "go_terms": [], "name": "Asp_decarboxylase_pyridox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022518": {"description": "Aspartate 4-decarboxylase", "go_ids": [], "go_terms": [], "name": "Aspartate_4-decarboxylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022519": {"description": "Gloeobacter/Verrucomicrobia repeat", "go_ids": [], "go_terms": [], "name": "Gloeo/Verruco_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR022520": {"description": "Putative glutamate/gamma-aminobutyrate antiporter", "go_ids": [], "go_terms": [], "name": "Glu/GABA_antiporter_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022521": {"description": "Rv3660c", "go_ids": [], "go_terms": [], "name": "Rv3660c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022522": {"description": "Flagellar motor stator, MotA", "go_ids": [], "go_terms": [], "name": "Flagellar_motor_stator_MotA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022523": {"description": "Flagellar regulator, FliZ", "go_ids": [], "go_terms": [], "name": "Flagellar_regulator_FliZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022524": {"description": "Flagellar assembly FliH, Bacilli", "go_ids": [], "go_terms": [], "name": "FliH_Bacilli", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022525": {"description": "Beta-lysine N-acetyltransferase", "go_ids": ["GO:0008080"], "go_terms": ["GO:0008080:N-acetyltransferase activity:F"], "name": "GNAT_AblB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022526": {"description": "F420-dependent oxidoreductase, Rv3093c", "go_ids": [], "go_terms": [], "name": "F420_Rv3093c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022527": {"description": "Sucrose phosphorylase", "go_ids": ["GO:0005975", "GO:0004645"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0004645:1,4-alpha-oligoglucan phosphorylase activity:F"], "name": "Sucrose_phospho", "pathway_ids": ["PWY-5384"], "pathways": ["PWY-5384:t:sucrose degradation IV (sucrose phosphorylase)"], "type": "Family"}, "IPR022528": {"description": "6-phosphogluconolactonase, YbhE-like", "go_ids": ["GO:0006098", "GO:0017057", "GO:0005975"], "go_terms": ["GO:0006098:pentose-phosphate shunt:P", "GO:0017057:6-phosphogluconolactonase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "6PGL_YbhE-like", "pathway_ids": ["PWY-8004"], "pathways": ["PWY-8004:t:Entner-Doudoroff pathway I"], "type": "Family"}, "IPR022529": {"description": "Protein of unknown function DUF3530", "go_ids": [], "go_terms": [], "name": "DUF3530", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022531": {"description": "RNA-directed RNA polymerase L, PA-C-like domain", "go_ids": [], "go_terms": [], "name": "L_PA-C-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022532": {"description": "Domain of unknown function DUF3696, C-terminal", "go_ids": [], "go_terms": [], "name": "DUF3696", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022533": {"description": "Cox20", "go_ids": ["GO:0033617", "GO:0005743"], "go_terms": ["GO:0033617:mitochondrial respiratory chain complex IV assembly:P", "GO:0005743:mitochondrial inner membrane:C"], "name": "Cox20", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848", "R-DRE-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-DRE-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR022534": {"description": "Protein of unknown function DUF2563", "go_ids": [], "go_terms": [], "name": "DUF2563", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022535": {"description": "Golgi pH regulator, conserved domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Golgi_pH-regulator_cons_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022536": {"description": "ESX-1 secretion-associated protein EspC", "go_ids": ["GO:0009306"], "go_terms": ["GO:0009306:protein secretion:P"], "name": "EspC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022537": {"description": "TRSP domain", "go_ids": [], "go_terms": [], "name": "TRSP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022538": {"description": "Protein of unknown function DUF2570", "go_ids": [], "go_terms": [], "name": "DUF2570", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022539": {"description": "Picornavirus VP1, conserved C-terminal region", "go_ids": [], "go_terms": [], "name": "VP1_C", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR022540": {"description": "Inner membrane protein YhdU", "go_ids": [], "go_terms": [], "name": "YhdU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022541": {"description": "FicA antitoxin homologue YhfG", "go_ids": [], "go_terms": [], "name": "YhfG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022542": {"description": "Focadhesin/RST, DUF3730", "go_ids": [], "go_terms": [], "name": "FOCAD/RST1_DUF3730", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022543": {"description": "Protein of unknown function DUF2572", "go_ids": [], "go_terms": [], "name": "DUF2572", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022544": {"description": "Bacteriophage P22, Orf80", "go_ids": [], "go_terms": [], "name": "Phage_P22_Orf80", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022545": {"description": "Human herpesvirus, UL121", "go_ids": [], "go_terms": [], "name": "HHV_UL121", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR022546": {"description": "Uncharacterised protein family Ycf68", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Ycf68", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022547": {"description": "ATPase, RavA, C-terminal", "go_ids": [], "go_terms": [], "name": "ATPase_RavA_C", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR022548": {"description": "Domain of unknown function DUF2846", "go_ids": [], "go_terms": [], "name": "DUF2846", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022549": {"description": "Domain of unknown function DUF3627", "go_ids": [], "go_terms": [], "name": "DUF3627", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022550": {"description": "Nucleotidyltransferase 8", "go_ids": [], "go_terms": [], "name": "NTP_transf_8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022551": {"description": "BrxC", "go_ids": [], "go_terms": [], "name": "BrxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022552": {"description": "Uncharacterised protein family Ycf55", "go_ids": [], "go_terms": [], "name": "UPF_Ycf55", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022553": {"description": "Protein of unknown function DUF2645", "go_ids": [], "go_terms": [], "name": "DUF2645", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022554": {"description": "Respiratory growth induced protein 1", "go_ids": ["GO:0006112"], "go_terms": ["GO:0006112:energy reserve metabolic process:P"], "name": "RGI1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022555": {"description": "Protein of unknown function, DUF2577", "go_ids": [], "go_terms": [], "name": "DUF2577", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022556": {"description": "Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf5", "go_ids": [], "go_terms": [], "name": "AcMNPV_Orf5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022557": {"description": "Smad anchor for receptor activation-like, C-terminal", "go_ids": [], "go_terms": [], "name": "SARA-like_C", "pathway_ids": ["R-HSA-3304356", "R-MMU-201451", "R-HSA-201451", "R-HSA-2173789", "R-HSA-2173788", "R-HSA-3656532"], "pathways": ["R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-MMU-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer"], "type": "Domain"}, "IPR022558": {"description": "Y03H", "go_ids": [], "go_terms": [], "name": "Y03H", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022559": {"description": "Protein SUP-1-like", "go_ids": [], "go_terms": [], "name": "SUP-1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022560": {"description": "Domain of unknown function DUF3473", "go_ids": [], "go_terms": [], "name": "DUF3473", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022562": {"description": "Protein of unknown function DUF3466", "go_ids": [], "go_terms": [], "name": "DUF3466", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022563": {"description": "Domain of unknown function DUF3463", "go_ids": [], "go_terms": [], "name": "DUF3463", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022564": {"description": "Protein of unknown function DUF2678", "go_ids": [], "go_terms": [], "name": "DUF2678", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022565": {"description": "Protein of unknown function DUF2608", "go_ids": [], "go_terms": [], "name": "DUF2608", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022566": {"description": "Protein of unknown function DUF2613", "go_ids": [], "go_terms": [], "name": "DUF2613", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022567": {"description": "Glycosyl hydrolase, C-terminal (DUF3459)", "go_ids": [], "go_terms": [], "name": "DUF3459", "pathway_ids": ["PWY-2661", "R-MTU-868688"], "pathways": ["PWY-2661:t:trehalose biosynthesis V", "R-MTU-868688:r:Trehalose biosynthesis"], "type": "Domain"}, "IPR022568": {"description": "Protein of unknown function DUF2824", "go_ids": [], "go_terms": [], "name": "DUF2824", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022569": {"description": "Ferredoxin, C-terminal", "go_ids": [], "go_terms": [], "name": "Fd_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022570": {"description": "NSP1, betacoronavirus lineage A", "go_ids": [], "go_terms": [], "name": "B-CoV_A_NSP1", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Family"}, "IPR022571": {"description": "Magnesium chelatase, subunit H, N-terminal", "go_ids": ["GO:0016851"], "go_terms": ["GO:0016851:magnesium chelatase activity:F"], "name": "Mg_chelatase_H_N", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Domain"}, "IPR022572": {"description": "DNA replication/recombination mediator RecO, N-terminal", "go_ids": [], "go_terms": [], "name": "DNA_rep/recomb_RecO_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022573": {"description": "Protein of unknown function DUF2887", "go_ids": [], "go_terms": [], "name": "DUF2887", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022574": {"description": "Protein of unknown function DUF2623", "go_ids": [], "go_terms": [], "name": "DUF2623", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022575": {"description": "Neurogenic differentiation factor, domain of unknown function", "go_ids": [], "go_terms": [], "name": "NeuroD_DUF", "pathway_ids": ["R-HSA-210746", "R-HSA-210745"], "pathways": ["R-HSA-210746:r:Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells", "R-HSA-210745:r:Regulation of gene expression in beta cells"], "type": "Domain"}, "IPR022576": {"description": "Protein YfgG", "go_ids": [], "go_terms": [], "name": "YfgG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022577": {"description": "Tubulin-folding cofactor D, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TBCD_C", "pathway_ids": ["R-HSA-389977"], "pathways": ["R-HSA-389977:r:Post-chaperonin tubulin folding pathway"], "type": "Domain"}, "IPR022578": {"description": "Flagellin, D2 domain", "go_ids": [], "go_terms": [], "name": "Flagellin_D2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022579": {"description": "Neuropilin, C-terminal", "go_ids": [], "go_terms": [], "name": "Neuropilin_C", "pathway_ids": ["R-HSA-399956", "R-RNO-399956", "R-DRE-399954", "R-RNO-445144", "R-MMU-399955", "R-HSA-376176", "R-DRE-194306", "R-HSA-9694614", "R-MMU-445144", "R-HSA-194306", "R-HSA-447041", "R-RNO-399954", "R-MMU-194306", "R-RNO-399955", "R-HSA-399954", "R-DRE-399956", "R-MMU-399954", "R-HSA-399955", "R-HSA-445144", "R-HSA-447038", "R-MMU-399956", "R-RNO-194306"], "pathways": ["R-HSA-399956:r:CRMPs in Sema3A signaling", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-445144:r:Signal transduction by L1", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-376176:r:Signaling by ROBO receptors", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-9694614:r:Attachment and Entry", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-447041:r:CHL1 interactions", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-447038:r:NrCAM interactions", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR"], "type": "Domain"}, "IPR022580": {"description": "Protein of unknown function DUF2639", "go_ids": [], "go_terms": [], "name": "DUF2639", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022581": {"description": "Spt5 transcription elongation factor, N-terminal", "go_ids": [], "go_terms": [], "name": "Spt5_N", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-GGA-112382", "R-HSA-167238", "R-GGA-75955", "R-MMU-113418", "R-GGA-674695", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DME-77075", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-DRE-6807505", "R-DRE-77075", "R-HSA-167287", "R-DRE-75955", "R-HSA-167246", "R-DRE-6796648", "R-DME-72086", "R-DRE-113418", "R-HSA-167152", "R-HSA-113418", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-GGA-6796648", "R-SCE-6796648", "R-SPO-113418", "R-DME-113418", "R-SPO-77075", "R-CEL-75955", "R-MMU-6796648", "R-GGA-6807505", "R-DME-674695", "R-HSA-167243", "R-SCE-113418", "R-SCE-72086", "R-DRE-72086", "R-HSA-167242", "R-CEL-113418", "R-CEL-77075", "R-MMU-674695", "R-MMU-6807505", "R-CEL-674695", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-DRE-674695", "R-MMU-77075", "R-HSA-75955", "R-SCE-77075", "R-CEL-112382", "R-HSA-167160", "R-SCE-674695", "R-MMU-72086", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-GGA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-GGA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-72086:r:mRNA Capping", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-GGA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-72086:r:mRNA Capping", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR022582": {"description": "T-box transcription factor 2/3, transcription activation domain", "go_ids": [], "go_terms": [], "name": "TBX2/3_TAD", "pathway_ids": ["R-MMU-9856649", "R-HSA-9825892", "R-HSA-9856649", "R-RNO-9856649"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Domain"}, "IPR022583": {"description": "Microcystin synthetase, domain of unknown function", "go_ids": [], "go_terms": [], "name": "Microcystin_synth_DUF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022584": {"description": "Protein of unknown function DUF2937", "go_ids": [], "go_terms": [], "name": "DUF2937", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022585": {"description": "Type IV secretion system coupling protein TraD, N-terminal", "go_ids": [], "go_terms": [], "name": "TraD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022586": {"description": "Swinepox virus, C51", "go_ids": [], "go_terms": [], "name": "Swinepox_virus_C51", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022587": {"description": "Myotubularin-related 12-like C-terminal domain", "go_ids": [], "go_terms": [], "name": "MTMR12-like_C", "pathway_ids": ["R-MMU-1660516", "R-DRE-1660516", "R-RNO-1660516", "R-HSA-1660516"], "pathways": ["R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DRE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane"], "type": "Domain"}, "IPR022588": {"description": "Protein of unknown function DUF2659", "go_ids": [], "go_terms": [], "name": "DUF2659", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022589": {"description": "Protein of unknown function DUF2660", "go_ids": [], "go_terms": [], "name": "DUF2660", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022590": {"description": "Peroxisome proliferator-activated receptor gamma, N-terminal", "go_ids": [], "go_terms": [], "name": "PPARgamma_N", "pathway_ids": ["R-HSA-1989781", "R-BTA-9841922", "R-HSA-381340", "R-BTA-381340", "R-HSA-9841922", "R-MMU-383280", "R-HSA-383280", "R-BTA-383280", "R-MMU-381340", "R-HSA-9844594", "R-HSA-8943724", "R-RNO-381340", "R-MMU-9841922", "R-HSA-4090294", "R-RNO-9841922", "R-RNO-383280", "R-HSA-9022707"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-BTA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-BTA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-HSA-9022707:r:MECP2 regulates transcription factors"], "type": "Domain"}, "IPR022591": {"description": "Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain", "go_ids": [], "go_terms": [], "name": "TAF1_HAT_dom", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DME-76042", "R-DDI-73776", "R-MMU-6804756", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-DDI-76042", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-CEL-73776", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-DME-674695", "R-DDI-73779", "R-MMU-674695", "R-SCE-76042", "R-DME-6804756", "R-CEL-674695", "R-HSA-167161", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-76042", "R-HSA-674695", "R-DDI-75953", "R-SPO-73776", "R-CEL-76042", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR022592": {"description": "Nucleolar protein 19", "go_ids": ["GO:0030686", "GO:0042274"], "go_terms": ["GO:0030686:90S preribosome:C", "GO:0042274:ribosomal small subunit biogenesis:P"], "name": "Nucleolar_19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022593": {"description": "2-oxoisovalerate dehydrogenase, E1 alpha subunit, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Oxoisoval_DH_suAlpha_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022594": {"description": "Autographa californica nuclear polyhedrosis virus (AcMNPV), 30.6kDa", "go_ids": [], "go_terms": [], "name": "AcMNPV_30.6kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022595": {"description": "Enterobacter phage Enc34, ssDNA-binding protein", "go_ids": [], "go_terms": [], "name": "Enc34_ssDNA-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022596": {"description": "G protein-coupled receptor GPR1/2/3, C-terminal", "go_ids": [], "go_terms": [], "name": "GPR1/2/3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022597": {"description": "Endoribonuclease antitoxin GhoS", "go_ids": ["GO:0004521"], "go_terms": ["GO:0004521:RNA endonuclease activity:F"], "name": "GhoS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022598": {"description": "Long-chain fatty acyl-CoA thioesterase FcoT-like", "go_ids": [], "go_terms": [], "name": "FcoT_ThioEstase", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8320", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8320:t:(3R)-N-[(2S)-1-hydroxy-6-[(3R)-3-isocyanobutanamido]hexan-2-yl]-3-isocyanobutanamide biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis"], "type": "Family"}, "IPR022599": {"description": "Lysis protein, bacteriophage MS2", "go_ids": [], "go_terms": [], "name": "Phage_MS2_lysis", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022600": {"description": "Frog virus 3, Orf82R", "go_ids": [], "go_terms": [], "name": "Frog_virus-3_Orf82R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022601": {"description": "Protein of unknown function DUF3160", "go_ids": [], "go_terms": [], "name": "DUF3160", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022602": {"description": "Protein of unknown function DUF2813", "go_ids": [], "go_terms": [], "name": "DUF2813", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022603": {"description": "Domain of unknown function DUF3152", "go_ids": [], "go_terms": [], "name": "DUF3152", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022604": {"description": "Domain of unknown function DUF2955", "go_ids": [], "go_terms": [], "name": "DUF2955", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022605": {"description": "Protein of unknown function DUF2920", "go_ids": [], "go_terms": [], "name": "DUF2920", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022606": {"description": "Domain of unknown function DUF2914", "go_ids": [], "go_terms": [], "name": "DUF2914", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022607": {"description": "Baseplate wedge protein gp53, bacteriophage T4", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp53_baseplate_wedge", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022608": {"description": "Transcription regulator SplA", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_SplA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022611": {"description": "Protein suppressor of silencing, bacteriophage T7", "go_ids": [], "go_terms": [], "name": "Phage_T7_5.5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022612": {"description": "Long-chain fatty aldehyde decarbonylase", "go_ids": ["GO:0071771"], "go_terms": ["GO:0071771:aldehyde oxygenase (deformylating) activity:F"], "name": "Ald_deCOase", "pathway_ids": ["PWY-7032", "PWY-282", "PWY-6622"], "pathways": ["PWY-7032:t:alkane biosynthesis I", "PWY-282:t:cuticular wax biosynthesis", "PWY-6622:t:heptadecane biosynthesis"], "type": "Family"}, "IPR022613": {"description": "CASAMP, second calponin-homology domain", "go_ids": [], "go_terms": [], "name": "CH_CAMSAP_2", "pathway_ids": ["R-MMU-389359", "R-MMU-9013106", "R-MMU-6811558", "R-MMU-114604", "R-MMU-3928665", "R-HSA-2871796", "R-HSA-912631", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-4420097", "R-HSA-9027284", "R-MMU-9013404", "R-RNO-512988", "R-RNO-2871809", "R-RNO-5218920", "R-RNO-912631", "R-HSA-4420097", "R-MMU-2871796", "R-BTA-389359", "R-HSA-5218920", "R-BTA-4420097", "R-RNO-6811558", "R-BTA-2871809", "R-HSA-389359", "R-BTA-6811558", "R-RNO-9013404", "R-HSA-512988", "R-HSA-9013408", "R-RNO-9013408", "R-RNO-193648", "R-RNO-9748787", "R-HSA-114604", "R-MMU-9748787", "R-MMU-1433557", "R-HSA-983695", "R-HSA-2424491", "R-HSA-416482", "R-HSA-2219530", "R-HSA-2029482", "R-BTA-912631", "R-MMU-445144", "R-HSA-6811558", "R-HSA-9013404", "R-RNO-1433557", "R-HSA-9013149", "R-MMU-9013423", "R-HSA-8980692", "R-HSA-9748787", "R-MMU-9013149", "R-MMU-193648", "R-BTA-114604", "R-HSA-9013026", "R-HSA-445144", "R-BTA-8980692", "R-HSA-1257604", "R-RNO-4420097", "R-RNO-2871796", "R-BTA-2029482", "R-MMU-8980692", "R-RNO-1257604", "R-RNO-8980692", "R-HSA-9013106", "R-MMU-9013148", "R-RNO-9027284", "R-RNO-2029482", "R-HSA-9013423", "R-RNO-416482", "R-RNO-389359", "R-BTA-2871796", "R-HSA-9013148", "R-MMU-512988", "R-MMU-9027284", "R-BTA-512988", "R-BTA-1433557", "R-HSA-193648", "R-MMU-912631", "R-MMU-5218920", "R-HSA-2871809", "R-HSA-9679191", "R-MMU-1257604", "R-HSA-1433557", "R-MMU-983695", "R-MMU-2029482", "R-BTA-416482", "R-RNO-114604", "R-BTA-9013408", "R-MMU-2871809", "R-HSA-3928665", "R-BTA-983695", "R-MMU-416482", "R-RNO-983695", "R-BTA-9013404", "R-BTA-1257604", "R-MMU-9013026", "R-MMU-2424491", "R-BTA-9027284", "R-HSA-9664422"], "pathways": ["R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-193648:r:NRAGE signals death through JNK", "R-RNO-9748787:r:Azathioprine ADME", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-9748787:r:Azathioprine ADME", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-912631:r:Regulation of signaling by CBL", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9748787:r:Azathioprine ADME", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-445144:r:Signal transduction by L1", "R-BTA-8980692:r:RHOA GTPase cycle", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-912631:r:Regulation of signaling by CBL", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-BTA-9013408:r:RHOG GTPase cycle", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-2424491:r:DAP12 signaling", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis"], "type": "Domain"}, "IPR022614": {"description": "Herpesvirus UL96 family", "go_ids": [], "go_terms": [], "name": "Herpesvirus_UL96", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR022615": {"description": "Na(+)-translocating NADH-quinone reductase subunit A, C-terminal domain", "go_ids": ["GO:0016655"], "go_terms": ["GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor:F"], "name": "NqrA_C_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022616": {"description": "Glycosyl hydrolase, family 4, C-terminal", "go_ids": ["GO:0004553"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "Glyco_hydro_4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022617": {"description": "Rad60/SUMO-like domain", "go_ids": [], "go_terms": [], "name": "Rad60/SUMO-like_dom", "pathway_ids": ["R-HSA-4655427", "R-GGA-3232142", "R-RNO-9615933", "R-HSA-4755510", "R-DRE-4085377", "R-HSA-9833482", "R-HSA-3065679", "R-MMU-4570464", "R-RNO-5693565", "R-HSA-5693565", "R-SCE-3065678", "R-SSC-4655427", "R-MMU-9615933", "R-RNO-877312", "R-SCE-4085377", "R-MMU-4551638", "R-HSA-4570464", "R-HSA-4090294", "R-SCE-3065679", "R-SPO-4085377", "R-GGA-9615933", "R-SSC-4570464", "R-SSC-4615885", "R-SPO-3899300", "R-RNO-4090294", "R-GGA-4570464", "R-CEL-4085377", "R-BTA-196791", "R-MMU-3065676", "R-DRE-9793242", "R-BTA-4755510", "R-RNO-5696395", "R-CEL-3065678", "R-XTR-3065679", "R-BTA-4551638", "R-GGA-877312", "R-XTR-4085377", "R-BTA-4085377", "R-HSA-3232142", "R-HSA-9615933", "R-CEL-4090294", "R-RNO-4085377", "R-DRE-196791", "R-DRE-3232118", "R-CEL-5696395", "R-HSA-5696395", "R-RNO-4570464", "R-HSA-3232118", "R-RNO-3232142", "R-SSC-3065678", "R-MMU-3108214", "R-XTR-3108214", "R-GGA-8866904", "R-SCE-3108214", "R-RNO-4615885", "R-DRE-5693607", "R-GGA-3065676", "R-SCE-4615885", "R-SPO-4615885", "R-MMU-3232142", "R-SCE-4570464", "R-GGA-4090294", "R-DRE-3065678", "R-GGA-9856649", "R-DRE-877312", "R-SPO-9615933", "R-BTA-3899300", "R-CEL-3899300", "R-DRE-4570464", "R-MMU-5693565", "R-XTR-5696395", "R-DRE-3108214", "R-BTA-4090294", "R-SSC-4085377", "R-HSA-196791", "R-RNO-3065679", "R-GGA-4755510", "R-HSA-877312", "R-DRE-3065679", "R-SSC-3899300", "R-RNO-9793242", "R-CEL-3108214", "R-GGA-3065678", "R-HSA-4615885", "R-MMU-4090294", "R-SCE-3232118", "R-MMU-877312", "R-MMU-5693607", "R-XTR-4090294", "R-RNO-3065676", "R-MMU-3899300", "R-RNO-9856649", "R-XTR-3232118", "R-BTA-4615885", "R-SPO-4551638", "R-CEL-9615933", "R-DRE-3899300", "R-SSC-4551638", "R-GGA-4655427", "R-HSA-3065676", "R-DRE-4090294", "R-GGA-4085377", "R-CEL-877312", "R-SCE-3065676", "R-HSA-9856649", "R-SPO-3065679", "R-GGA-3065679", "R-RNO-3065678", "R-MMU-9856649", "R-SCE-9615933", "R-XTR-4615885", "R-SSC-3065679", "R-DRE-3232142", "R-HSA-8866904", "R-HSA-3065678", "R-DRE-4551638", "R-BTA-3232118", "R-RNO-3108214", "R-SPO-3065678", "R-XTR-4570464", "R-SSC-9615933", "R-SPO-5696395", "R-MMU-5696395", "R-XTR-4551638", "R-HSA-5693607", "R-RNO-8866904", "R-GGA-4615885", "R-RNO-3232118", "R-MMU-4655427", "R-MMU-3232118", "R-CEL-4551638", "R-GGA-5693565", "R-BTA-5693607", "R-SCE-3899300", "R-CEL-9856649", "R-SSC-3108214", "R-HSA-4551638", "R-RNO-3899300", "R-SPO-3065676", "R-CEL-8866904", "R-SSC-4090294", "R-HSA-9683610", "R-HSA-9918432", "R-CEL-3232118", "R-RNO-5693607", "R-DRE-8866904", "R-SSC-3232118", "R-HSA-9694631", "R-DRE-3065676", "R-CEL-9793242", "R-RNO-196791", "R-SPO-4570464", "R-MMU-196791", "R-BTA-3065679", "R-MMU-3065679", "R-DRE-5693565", "R-GGA-3232118", "R-CEL-3065676", "R-CEL-4570464", "R-MMU-9793242", "R-SPO-3232118", "R-GGA-3899300", "R-HSA-3108214", "R-DRE-4615885", "R-SSC-9856649", "R-GGA-3108214", "R-DRE-4655427", "R-SCE-9856649", "R-BTA-4570464", "R-GGA-4551638", "R-BTA-3108214", "R-GGA-9793242", "R-MMU-4615885", "R-DRE-5696395", "R-SSC-4755510", "R-MMU-4085377", "R-SSC-877312", "R-CEL-3232142", "R-BTA-5696395", "R-MMU-3065678", "R-SSC-9793242", "R-SSC-8866904", "R-CEL-4615885", "R-SSC-3232142", "R-SPO-3108214", "R-SSC-5696395", "R-DRE-4755510", "R-HSA-4085377", "R-DRE-9856649", "R-SCE-9793242", "R-RNO-4755510", "R-SSC-5693565", "R-GGA-5696395", "R-RNO-4551638", "R-XTR-3899300", "R-RNO-4655427", "R-XTR-196791", "R-SCE-4551638", "R-DRE-9615933", "R-HSA-9793242", "R-HSA-9843940", "R-MMU-8866904", "R-CEL-3065679", "R-HSA-3899300", "R-SPO-9793242", "R-SSC-3065676", "R-MMU-4755510"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-GGA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-DRE-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-3065679:r:SUMO is proteolytically processed", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SSC-4655427:r:SUMOylation of DNA methylation proteins", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-877312:r:Regulation of IFNG signaling", "R-SCE-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-SCE-3065679:r:SUMO is proteolytically processed", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-GGA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SSC-4570464:r:SUMOylation of RNA binding proteins", "R-SSC-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-GGA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-4085377:r:SUMOylation of SUMOylation proteins", "R-BTA-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-DRE-9793242:r:SUMOylation of nuclear envelope proteins", "R-BTA-4755510:r:SUMOylation of immune response proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-XTR-3065679:r:SUMO is proteolytically processed", "R-BTA-4551638:r:SUMOylation of chromatin organization proteins", "R-GGA-877312:r:Regulation of IFNG signaling", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-BTA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-4090294:r:SUMOylation of intracellular receptors", 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"PWY-5041:t:S-adenosyl-L-methionine salvage II", "R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-SCE-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-DME-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-DME-156581:r:Methylation", "R-RNO-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-SPO-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-SCE-156581:r:Methylation", "R-SCE-1614635:r:Sulfur amino acid metabolism", "R-CEL-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-MMU-156581:r:Methylation", "R-SPO-156581:r:Methylation", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-SPO-1614635:r:Sulfur amino acid metabolism", "R-MMU-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-RNO-156581:r:Methylation", "R-HSA-156581:r:Methylation", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-DME-1614635:r:Sulfur amino acid metabolism", "R-HSA-5579024:r:Defective MAT1A causes MATD", "R-DDI-156581:r:Methylation", "R-DDI-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "type": "Homologous_superfamily"}, "IPR022637": {"description": "DNA polymerase III, beta sliding clamp, central", "go_ids": ["GO:0006260", "GO:0003887", "GO:0008408", "GO:0009360"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0008408:3'-5' exonuclease activity:F", "GO:0009360:DNA polymerase III complex:C"], "name": "DNA_polIII_beta_cen", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022639": {"description": "Translocated intimin receptor, C-terminal", "go_ids": [], "go_terms": [], "name": "Transloc_intimin_rcpt_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022640": {"description": "Cysteine and tyrosine-rich protein 1", "go_ids": [], "go_terms": [], "name": "CYYR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022641": {"description": "Chemotaxis receptor methyltransferase CheR, N-terminal", "go_ids": [], "go_terms": [], "name": "CheR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022642": {"description": "MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal", "go_ids": [], "go_terms": [], "name": "CheR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022643": {"description": "Orn/DAP/Arg decarboxylase 2, C-terminal", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "De-COase2_C", "pathway_ids": ["R-CEL-351143", "R-HSA-351202", "R-RNO-351202", "R-RNO-350562", "R-BTA-351202", "R-MMU-351202", "R-CEL-350562", "R-CEL-351202", "R-HSA-350562", "R-MMU-350562", "R-RNO-351143", "R-BTA-350562"], "pathways": ["R-CEL-351143:r:Agmatine biosynthesis", 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{"description": "Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, N-terminal", "go_ids": ["GO:0006730", "GO:0016740"], "go_terms": ["GO:0006730:one-carbon metabolic process:P", "GO:0016740:transferase activity:F"], "name": "ForMFR_H4MPT_ForTrfase_N", "pathway_ids": ["PWY-5209", "PWY-7784", "PWY-8305"], "pathways": ["PWY-5209:t:methyl-coenzyme M oxidation to CO2 I", "PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)", "PWY-8305:t:methoxylated aromatic compound degradation II"], "type": "Domain"}, "IPR022669": {"description": "Large ribosomal subunit protein uL2, C-terminal", "go_ids": ["GO:0006412", "GO:0003735", "GO:0005840"], "go_terms": ["GO:0006412:translation:P", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C"], "name": "Ribosomal_uL2_C", "pathway_ids": ["R-RNO-9629569", "R-HSA-5419276", "R-XTR-6791226", "R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", 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"R-RNO-70171", "R-HSA-446205", "R-HSA-9615017", "R-SCE-170822", "R-RNO-170822", "R-SPO-446205", "R-SPO-170822", "R-HSA-5619107", "R-MMU-6798695", "R-SCE-446205", "R-HSA-5619056", "R-HSA-70171", "R-SPO-70171"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-70171:r:Glycolysis", "R-SPO-6798695:r:Neutrophil degranulation", "R-SCE-70171:r:Glycolysis", "R-DME-446205:r:Synthesis of GDP-mannose", "R-HSA-5619073:r:Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-70171:r:Glycolysis", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DME-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-70171:r:Glycolysis", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SCE-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-SPO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-446205:r:Synthesis of GDP-mannose", "R-HSA-5619056:r:Defective HK1 causes hexokinase deficiency (HK deficiency)", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis"], "type": "Domain"}, "IPR022674": {"description": "Glucose-6-phosphate dehydrogenase, NAD-binding", "go_ids": ["GO:0006006", "GO:0050661"], "go_terms": ["GO:0006006:glucose metabolic process:P", "GO:0050661:NADP binding:F"], "name": "G6P_DH_NAD-bd", "pathway_ids": ["PWY-7268", "PWY-8004", "R-MMU-71336", "R-SPO-71336", "R-HSA-71336", "R-DDI-5628897", "R-SCE-5628897", "R-SPO-5628897", "R-CEL-5628897", "R-RNO-5628897", "R-DDI-71336", "R-PFA-71336", "R-RNO-71336", "R-HSA-5628897", "R-DME-71336", "R-SCE-71336", "R-PFA-5628897", "R-MMU-5628897", "R-CEL-71336", "R-HSA-9818028", "R-DME-5628897"], "pathways": ["PWY-7268:t:cytosolic NADPH production (yeast)", "PWY-8004:t:Entner-Doudoroff pathway I", "R-MMU-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-71336:r:Pentose phosphate pathway", "R-PFA-71336:r:Pentose phosphate pathway", "R-RNO-71336:r:Pentose phosphate pathway", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-71336:r:Pentose phosphate pathway", "R-SCE-71336:r:Pentose phosphate pathway", "R-PFA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-71336:r:Pentose phosphate pathway", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-DME-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Domain"}, "IPR022675": {"description": "Glucose-6-phosphate dehydrogenase, C-terminal", "go_ids": ["GO:0050661", "GO:0006006", "GO:0004345"], "go_terms": ["GO:0050661:NADP binding:F", "GO:0006006:glucose metabolic process:P", "GO:0004345:glucose-6-phosphate dehydrogenase activity:F"], "name": "G6P_DH_C", "pathway_ids": ["PWY-7268", "PWY-8004", "R-MMU-71336", "R-SPO-71336", "R-HSA-71336", "R-DDI-5628897", "R-SCE-5628897", "R-SPO-5628897", "R-CEL-5628897", "R-RNO-5628897", "R-DDI-71336", "R-PFA-71336", "R-RNO-71336", "R-HSA-5628897", "R-DME-71336", "R-SCE-71336", "R-PFA-5628897", "R-MMU-5628897", "R-CEL-71336", "R-HSA-9818028", "R-DME-5628897"], "pathways": ["PWY-7268:t:cytosolic NADPH production (yeast)", "PWY-8004:t:Entner-Doudoroff pathway I", "R-MMU-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-71336:r:Pentose phosphate pathway", "R-PFA-71336:r:Pentose phosphate pathway", "R-RNO-71336:r:Pentose phosphate pathway", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-71336:r:Pentose phosphate pathway", "R-SCE-71336:r:Pentose phosphate pathway", "R-PFA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-71336:r:Pentose phosphate pathway", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-DME-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Domain"}, "IPR022676": {"description": "Glycylpeptide N-tetradecanoyltransferase, N-terminal", "go_ids": ["GO:0004379"], "go_terms": ["GO:0004379:glycylpeptide N-tetradecanoyltransferase activity:F"], "name": "NMT_N", "pathway_ids": ["R-HSA-2514859", "R-MMU-2514859", "R-HSA-9918432", "R-SPO-2514859", "R-HSA-174490", "R-HSA-203615", "R-RNO-2514859", "R-DRE-2514859", "R-CEL-2514859", "R-HSA-75108", "R-DDI-2514859", "R-SCE-2514859", "R-HSA-162599", "R-RNO-75108", "R-BTA-2514859", "R-MMU-75108"], "pathways": ["R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-9918432:r:Maturation of DENV proteins", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-203615:r:eNOS activation", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DRE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SCE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-162599:r:Late Phase of HIV Life Cycle", "R-RNO-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-75108:r:Activation, myristolyation of BID and translocation to mitochondria"], "type": "Domain"}, "IPR022677": {"description": "Glycylpeptide N-tetradecanoyltransferase, C-terminal", "go_ids": ["GO:0004379"], "go_terms": ["GO:0004379:glycylpeptide N-tetradecanoyltransferase activity:F"], "name": "NMT_C", "pathway_ids": ["R-HSA-2514859", "R-MMU-2514859", "R-HSA-9918432", "R-SPO-2514859", "R-HSA-174490", "R-HSA-203615", "R-RNO-2514859", "R-DRE-2514859", "R-CEL-2514859", "R-HSA-75108", "R-DDI-2514859", "R-SCE-2514859", "R-HSA-162599", "R-RNO-75108", "R-BTA-2514859", "R-MMU-75108"], "pathways": ["R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-9918432:r:Maturation of DENV proteins", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-203615:r:eNOS activation", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DRE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SCE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-162599:r:Late Phase of HIV Life Cycle", "R-RNO-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-75108:r:Activation, myristolyation of BID and translocation to mitochondria"], "type": "Domain"}, "IPR022679": {"description": "Methyl-coenzyme M reductase, beta subunit, C-terminal", "go_ids": ["GO:0050524"], "go_terms": ["GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_bsu_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022680": {"description": "Methyl-coenzyme M reductase, beta subunit, N-terminal", "go_ids": ["GO:0050524"], "go_terms": ["GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_bsu_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022682": {"description": "Peptidase C2, calpain, large subunit, domain III", "go_ids": [], "go_terms": [], "name": "Calpain_domain_III", "pathway_ids": ["R-HSA-1474228", "R-HSA-6798695", "R-RNO-6798695", "R-DDI-6798695", "R-SSC-6798695", "R-HSA-6809371", "R-MMU-9856530", "R-DME-6798695", "R-RNO-1474228", "R-CEL-6798695", "R-BTA-1474228", "R-HSA-8862803", "R-SSC-1474228", "R-RNO-9860927", "R-RNO-9856530", "R-BTA-9860927", "R-SSC-6809371", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-9856530", "R-BTA-9856530", "R-MMU-9860927", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SSC-6809371:r:Formation of the cornified envelope", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR022683": {"description": "Peptidase C2, calpain, domain III", "go_ids": [], "go_terms": [], "name": "Calpain_III", "pathway_ids": ["R-HSA-1474228", "R-HSA-6798695", "R-RNO-6798695", "R-DDI-6798695", "R-SSC-6798695", "R-HSA-6809371", "R-MMU-9856530", "R-DME-6798695", "R-RNO-1474228", "R-CEL-6798695", "R-BTA-1474228", "R-HSA-8862803", "R-SSC-1474228", "R-RNO-9860927", "R-RNO-9856530", "R-BTA-9860927", "R-SSC-6809371", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-9856530", "R-BTA-9856530", "R-MMU-9860927", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SSC-6809371:r:Formation of the cornified envelope", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR022684": {"description": "Peptidase C2, calpain family", "go_ids": ["GO:0006508", "GO:0004198"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0004198:calcium-dependent cysteine-type endopeptidase activity:F"], "name": "Calpain_cysteine_protease", "pathway_ids": ["R-HSA-1474228", "R-HSA-6798695", "R-RNO-6798695", "R-DDI-6798695", "R-SSC-6798695", "R-HSA-6809371", "R-MMU-9856530", "R-DME-6798695", "R-RNO-1474228", "R-CEL-6798695", "R-BTA-1474228", "R-HSA-8862803", "R-SSC-1474228", "R-RNO-9860927", "R-RNO-9856530", "R-BTA-9860927", "R-SSC-6809371", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-9856530", "R-BTA-9856530", "R-MMU-9860927", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SSC-6809371:r:Formation of the cornified envelope", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Family"}, "IPR022686": {"description": "Replication-associated protein G2P, N-terminal", "go_ids": ["GO:0006260"], "go_terms": ["GO:0006260:DNA replication:P"], "name": "G2P_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022687": {"description": "DTXR-type, HTH domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "HTH_DTXR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022688": {"description": "Replication-associated protein G2P, C-terminal", "go_ids": ["GO:0006260"], "go_terms": ["GO:0006260:DNA replication:P"], "name": "G2P_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022689": {"description": "Iron dependent repressor", "go_ids": ["GO:0046914", "GO:0006355", "GO:0003700"], "go_terms": ["GO:0046914:transition metal ion binding:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "Iron_dep_repressor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022691": {"description": "Transcription elongation factor, GreA/GreB, N-terminal", "go_ids": ["GO:0003677", "GO:0032784"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0032784:regulation of DNA-templated transcription elongation:P"], "name": "Tscrpt_elong_fac_GreA/B_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022692": {"description": "Geminivirus AL1 replication-associated protein, central domain", "go_ids": ["GO:0016888"], "go_terms": ["GO:0016888:DNA endonuclease activity, producing 5'-phosphomonoesters:F"], "name": "Gemini_AL1_REP_central", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR022694": {"description": "3-hydroxyacyl-CoA dehydrogenase", "go_ids": ["GO:0006631", "GO:0070403", "GO:0016616"], "go_terms": ["GO:0006631:fatty acid metabolic process:P", "GO:0070403:NAD+ binding:F", "GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "3-OHacyl-CoA_DH", "pathway_ids": ["R-SSC-77352", "R-RNO-77352", "R-SSC-77348", "R-RNO-5661270", "R-MMU-9837999", "R-RNO-77346", "R-CEL-9837999", "R-CEL-77348", "R-SSC-77350", "R-CEL-77350", "R-CEL-77352", "R-MMU-77350", "R-RNO-77310", "R-HSA-77350", "R-CEL-77310", "R-HSA-77348", "R-MMU-77348", "R-RNO-9837999", "R-HSA-77346", "R-MMU-77352", "R-SSC-77346", "R-HSA-5661270", "R-SSC-77310", "R-MMU-77346", "R-RNO-77350", "R-BTA-5661270", "R-HSA-77310", "R-MMU-5661270", "R-MMU-77310", "R-RNO-77348", "R-SSC-9837999", "R-HSA-9837999", "R-HSA-77352", "R-CEL-77346"], "pathways": ["R-SSC-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SSC-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-CEL-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-SSC-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-CEL-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-CEL-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-CEL-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SSC-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-BTA-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "type": "Family"}, "IPR022695": {"description": "Histidinol dehydrogenase, monofunctional", "go_ids": ["GO:0046872", "GO:0000105", "GO:0004399", "GO:0051287"], "go_terms": ["GO:0046872:metal ion binding:F", "GO:0000105:L-histidine biosynthetic process:P", "GO:0004399:histidinol dehydrogenase activity:F", "GO:0051287:NAD binding:F"], "name": "Histidinol_DH_monofunct", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022697": {"description": "Homoserine dehydrogenase lacking ACT domain", "go_ids": ["GO:0004412"], "go_terms": ["GO:0004412:homoserine dehydrogenase activity:F"], "name": "HDH_short", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022698": {"description": "Orsellinic acid/F9775 biosynthesis cluster protein D", "go_ids": [], "go_terms": [], "name": "OrsD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022699": {"description": "Stonin-2, N-terminal", "go_ids": [], "go_terms": [], "name": "Stonin2_N", "pathway_ids": ["R-RNO-8856828", "R-MMU-8856828", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828"], "pathways": ["R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis"], "type": "Domain"}, "IPR022700": {"description": "Proteinase, regulatory CLIP domain", "go_ids": [], "go_terms": [], "name": "CLIP", "pathway_ids": ["PWY-7884", "R-DME-209442"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'"], "type": "Domain"}, "IPR022701": {"description": "tRNA-queuosine alpha-mannosyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "QTMAN_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022702": {"description": "DNA (cytosine-5)-methyltransferase 1, replication foci domain", "go_ids": [], "go_terms": [], "name": "DNMT1-RFD", "pathway_ids": ["R-HSA-4655427", "R-RNO-4655427", "R-HSA-9725371", "R-HSA-212300", "R-RNO-212300", "R-MMU-4655427", "R-HSA-427413", "R-MMU-212300", "R-HSA-5334118", "R-HSA-9701898", "R-HSA-9710421"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-MMU-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-5334118:r:DNA methylation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9710421:r:Defective pyroptosis"], "type": "Domain"}, "IPR022703": {"description": "Domain of unknown function DUF3533", "go_ids": [], "go_terms": [], "name": "DUF3533", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022704": {"description": "Protein of unknown function DUF2746", "go_ids": [], "go_terms": [], "name": "DUF2746", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022706": {"description": "Antifungal protein", "go_ids": ["GO:0050832"], "go_terms": ["GO:0050832:defense response to fungus:P"], "name": "Antifungal_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022707": {"description": "Mot1, central domain", "go_ids": [], "go_terms": [], "name": "Mot1_central_dom", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR022708": {"description": "Serine/threonine-protein kinase Atg1-like, tMIT domain", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "Atg1-like_tMIT", "pathway_ids": ["R-SCE-1632852", "R-HSA-8934903", "R-SPO-8934903", "R-MMU-8934903", "R-HSA-5357905", "R-MMU-8876198", "R-HSA-8854214", "R-CEL-8934903", "R-MMU-5357905", "R-SCE-8934903", "R-MMU-1632852", "R-HSA-1632852", "R-CEL-1632852", "R-SPO-1632852", "R-HSA-8876198", "R-CEL-8854214", "R-SPO-8876198", "R-MMU-8854214"], "pathways": ["R-SCE-1632852:r:Macroautophagy", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8854214:r:TBC/RABGAPs", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-MMU-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8854214:r:TBC/RABGAPs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8854214:r:TBC/RABGAPs"], "type": "Domain"}, "IPR022709": {"description": "Protein SCAI", "go_ids": ["GO:0003714", "GO:0006351"], "go_terms": ["GO:0003714:transcription corepressor activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "SCAI", "pathway_ids": ["R-HSA-5663220", "R-MMU-5663220"], "pathways": ["R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR022710": {"description": "Metallothionein domain, yeast", "go_ids": ["GO:0005507", "GO:0046870", "GO:0010273", "GO:0071585"], "go_terms": ["GO:0005507:copper ion binding:F", "GO:0046870:cadmium ion binding:F", "GO:0010273:detoxification of copper ion:P", "GO:0071585:detoxification of cadmium ion:P"], "name": "Metalthion_dom_yeast", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022711": {"description": "Ribonuclease Y, N-terminal", "go_ids": [], "go_terms": [], "name": "RNase_Y_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022712": {"description": "Beta-Casp domain", "go_ids": [], "go_terms": [], "name": "Beta_Casp", "pathway_ids": ["R-CEL-159231", "R-RNO-6807505", "R-HSA-6807505", "R-DME-77595", "R-MMU-9770562", "R-SPO-159231", "R-MMU-77595", "R-HSA-73856", "R-DME-159231", "R-DDI-9770562", "R-CEL-73856", "R-HSA-72187", "R-DRE-6807505", "R-CEL-77595", "R-HSA-77595", "R-DME-9770562", "R-CEL-9770562", "R-DME-73856", "R-HSA-9918481", "R-MMU-159231", "R-BTA-77595", "R-HSA-9770562", "R-SCE-77595", "R-MMU-73856", "R-BTA-73856", "R-SPO-77595", "R-MMU-6807505", "R-DDI-6807505", "R-HSA-159231", "R-DME-6807505", "R-SPO-9770562", "R-MMU-72187", "R-DDI-77595", "R-BTA-9770562", "R-BTA-159231"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript"], "type": "Domain"}, "IPR022713": {"description": "Proteinase inhibitor I67, bromein", "go_ids": [], "go_terms": [], "name": "Prot_inhib_I67_bromein", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022714": {"description": "Protein of unknown function DUF2670", "go_ids": [], "go_terms": [], "name": "DUF2670", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022715": {"description": "Protein of unknown function DUF2671", "go_ids": [], "go_terms": [], "name": "DUF2671", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022716": {"description": "Gcn1, N-terminal", "go_ids": [], "go_terms": [], "name": "Gcn1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022717": {"description": "Antimicrobial peptide tachystatin A", "go_ids": [], "go_terms": [], "name": "Antimicrobial_tachystatin_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022718": {"description": "Protein of unknown function DUF2672", "go_ids": [], "go_terms": [], "name": "DUF2672", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022719": {"description": "Gliding motility-associated protein GldM, C-terminal", "go_ids": [], "go_terms": [], "name": "Motility-assoc_prot_GldM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022720": {"description": "Type IX secretion system motor protein PorM/GldM, N-terminal", "go_ids": [], "go_terms": [], "name": "T9SS_motor_PorM/GldM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022721": {"description": "Protein of unknown function DUF3561", "go_ids": [], "go_terms": [], "name": "DUF3561", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022722": {"description": "Non-structural protein ORF8, betacoronavirus", "go_ids": [], "go_terms": [], "name": "ORF8_betacoronavirus", "pathway_ids": ["R-HSA-983170", "R-HSA-448424", "R-HSA-9727281", "R-HSA-9705671", "R-HSA-9679504", "R-HSA-9692916"], "pathways": ["R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-448424:r:Interleukin-17 signaling", "R-HSA-9727281:r:Translation of Accessory Proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Family"}, "IPR022723": {"description": "RDM domain, Ret finger protein-like", "go_ids": [], "go_terms": [], "name": "RDM_domain_RFPL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022724": {"description": "RNA methyltransferase, SpoU/TrmH type, C-terminal domain", "go_ids": ["GO:0141100"], "go_terms": ["GO:0141100:tRNA (guanine(18)-2'-O-ribose)-methyltransferase activity:F"], "name": "rRNA_MeTrfase_SpoU_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022725": {"description": "Type II restriction enzyme MunI", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_MunI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022726": {"description": "CXC chemokine receptor 4 N-terminal domain", "go_ids": ["GO:0019955"], "go_terms": ["GO:0019955:cytokine binding:F"], "name": "Chemokine_CXCR4_N_dom", "pathway_ids": ["R-HSA-9827857", "R-HSA-418594", "R-MMU-376176", "R-HSA-380108", "R-HSA-173107", "R-HSA-9823730", "R-SSC-380108", "R-HSA-376176", "R-MMU-380108", "R-HSA-9937080", "R-RNO-380108", "R-SSC-418594", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-HSA-9827857:r:Specification of primordial germ cells", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-380108:r:Chemokine receptors bind chemokines", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-9823730:r:Formation of definitive endoderm", "R-SSC-380108:r:Chemokine receptors bind chemokines", "R-HSA-376176:r:Signaling by ROBO receptors", "R-MMU-380108:r:Chemokine receptors bind chemokines", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-RNO-380108:r:Chemokine receptors bind chemokines", "R-SSC-418594:r:G alpha (i) signalling events", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Domain"}, "IPR022727": {"description": "Pupal cuticle protein C1", "go_ids": [], "go_terms": [], "name": "Cuticle_C1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022728": {"description": "Period circadian-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Period_circadian-like_C", "pathway_ids": ["R-HSA-9931510", "R-RNO-9932298", "R-HSA-9931530", "R-MMU-9932298", "R-HSA-9932298", "R-HSA-9931521"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex"], "type": "Domain"}, "IPR022730": {"description": "DAZ associated protein 2", "go_ids": [], "go_terms": [], "name": "DAZ_assoc-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022731": {"description": "Dermaseptin domain", "go_ids": [], "go_terms": [], "name": "Dermaseptin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022732": {"description": "Peptidase S54, GlpG peptidase, N-terminal", "go_ids": ["GO:0004252", "GO:0016020"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0016020:membrane:C"], "name": "Peptidase_S54_GlpG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022733": {"description": "DPUP/SUD, C-terminal, betacoronavirus", "go_ids": [], "go_terms": [], "name": "DPUP_SUD_C_bCoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR022734": {"description": "Apolipoprotein M", "go_ids": [], "go_terms": [], "name": "ApoM", "pathway_ids": ["R-MMU-975634", "R-SSC-975634", "R-RNO-975634", "R-HSA-975634"], "pathways": ["R-MMU-975634:r:Retinoid metabolism and transport", "R-SSC-975634:r:Retinoid metabolism and transport", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Family"}, "IPR022735": {"description": "bMERB domain", "go_ids": [], "go_terms": [], "name": "bMERB_dom", "pathway_ids": ["R-HSA-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR022736": {"description": "Non-structural protein NS6, betacoronavirus", "go_ids": ["GO:0044165"], "go_terms": ["GO:0044165:host cell endoplasmic reticulum:C"], "name": "NS6_bCoV", "pathway_ids": ["R-HSA-9727281", "R-HSA-9692916", "R-HSA-9705671"], "pathways": ["R-HSA-9727281:r:Translation of Accessory Proteins", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses"], "type": "Family"}, "IPR022737": {"description": "RNA polymerase recycling, bacterial, C-terminal", "go_ids": ["GO:0016817"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F"], "name": "RapA_C", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR022738": {"description": "Adenylylsulphate reductase, beta subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "AprB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022739": {"description": "Polyphenol oxidase, central domain", "go_ids": ["GO:0004097"], "go_terms": ["GO:0004097:catechol oxidase activity:F"], "name": "Polyphenol_oxidase_cen", "pathway_ids": ["PWY-6752"], "pathways": ["PWY-6752:t:ortho-quinones biosynthesis"], "type": "Domain"}, "IPR022740": {"description": "Polyphenol oxidase, C-terminal", "go_ids": ["GO:0004097"], "go_terms": ["GO:0004097:catechol oxidase activity:F"], "name": "Polyphenol_oxidase_C", "pathway_ids": ["PWY-6752"], "pathways": ["PWY-6752:t:ortho-quinones biosynthesis"], "type": "Domain"}, "IPR022741": {"description": "Bacteriophage B103, Gp8, head fibre", "go_ids": [], "go_terms": [], "name": "Phage_B103_Gp8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022742": {"description": "Alpha/beta hydrolase domain-containing protein 17C-like", "go_ids": [], "go_terms": [], "name": "ABHD17C-like", "pathway_ids": ["R-GGA-9648002", "R-DRE-9648002", "R-MMU-9648002", "R-HSA-426048", "R-XTR-9648002", "R-BTA-9648002", "R-RNO-426048", "R-MMU-426048", "R-RNO-1482883", "R-DDI-426048", "R-HSA-163560", "R-DDI-1482883", "R-CEL-9648002", "R-HSA-9841922", "R-SPO-1482883", "R-MMU-1482883", "R-SPO-426048", "R-HSA-1482883", "R-SCE-1482883", "R-RNO-9648002", "R-HSA-9648002", "R-SCE-426048"], "pathways": ["R-GGA-9648002:r:RAS processing", "R-DRE-9648002:r:RAS processing", "R-MMU-9648002:r:RAS processing", "R-HSA-426048:r:Arachidonate production from DAG", "R-XTR-9648002:r:RAS processing", "R-BTA-9648002:r:RAS processing", "R-RNO-426048:r:Arachidonate production from DAG", "R-MMU-426048:r:Arachidonate production from DAG", "R-RNO-1482883:r:Acyl chain remodeling of DAG and TAG", "R-DDI-426048:r:Arachidonate production from DAG", "R-HSA-163560:r:Triglyceride catabolism", "R-DDI-1482883:r:Acyl chain remodeling of DAG and TAG", "R-CEL-9648002:r:RAS processing", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SPO-1482883:r:Acyl chain remodeling of DAG and TAG", "R-MMU-1482883:r:Acyl chain remodeling of DAG and TAG", "R-SPO-426048:r:Arachidonate production from DAG", "R-HSA-1482883:r:Acyl chain remodeling of DAG and TAG", "R-SCE-1482883:r:Acyl chain remodeling of DAG and TAG", "R-RNO-9648002:r:RAS processing", "R-HSA-9648002:r:RAS processing", "R-SCE-426048:r:Arachidonate production from DAG"], "type": "Domain"}, "IPR022744": {"description": "Methyltransferase domain, putative", "go_ids": [], "go_terms": [], "name": "MeTrfase_dom_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022745": {"description": "Eukaryotic translation initiation factor 4G1, eIF4E-binding domain", "go_ids": [], "go_terms": [], "name": "eIF4G1_eIF4E-bd", "pathway_ids": ["R-SPO-975956", "R-SCE-156827", "R-SCE-72649", "R-SPO-72662", "R-SCE-975957", "R-SPO-72702", "R-SPO-72706", "R-SPO-72649", "R-SCE-975956", "R-SCE-72662", "R-SPO-156827", "R-SCE-166208", "R-SPO-975957", "R-SPO-166208", "R-SPO-429947", "R-SCE-72702", "R-SCE-429947"], "pathways": ["R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72649:r:Translation initiation complex formation", "R-SPO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-166208:r:mTORC1-mediated signalling", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-166208:r:mTORC1-mediated signalling", "R-SPO-429947:r:Deadenylation of mRNA", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-429947:r:Deadenylation of mRNA"], "type": "Domain"}, "IPR022746": {"description": "Cathelicidin, antimicrobial peptide, C-terminal", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense response to bacterium:P"], "name": "Cathlecidin_C", "pathway_ids": ["R-MMU-6798695", "R-MMU-6803157", "R-HSA-6803157", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR022747": {"description": "Salmonella outer protein D", "go_ids": ["GO:0033644"], "go_terms": ["GO:0033644:host cell membrane:C"], "name": "SopD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022748": {"description": "NADH dehydrogenase subunit 2, N-terminal", "go_ids": [], "go_terms": [], "name": "NADH_DH_su2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022749": {"description": "N6 adenine-specific DNA methyltransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "D12N6_MeTrfase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022750": {"description": "Interferon regulatory factor 2-binding protein 1/2-like, zinc finger", "go_ids": [], "go_terms": [], "name": "IRF-2BP1_2-like_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022751": {"description": "Alpha-mannosyltransferase", "go_ids": ["GO:0009101", "GO:0016757"], "go_terms": ["GO:0009101:glycoprotein biosynthetic process:P", "GO:0016757:glycosyltransferase activity:F"], "name": "Alpha_mannosyltransferase", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR022752": {"description": "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "STAT1_TAZ2-bd_C", "pathway_ids": ["R-MMU-8985947", "R-HSA-9705671", "R-HSA-9942503", "R-HSA-1059683", "R-HSA-9833482", "R-HSA-9020958", "R-HSA-9680350", "R-MMU-9020956", "R-HSA-1169408", "R-HSA-9670439", "R-MMU-9020958", "R-MMU-9833482", "R-HSA-9673770", "R-HSA-9725370", "R-HSA-877312", "R-HSA-2173795", "R-HSA-912694", "R-HSA-9673767", "R-MMU-909733", "R-MMU-186763", "R-MMU-877312", "R-HSA-8984722", "R-MMU-6785807", "R-MMU-8854691", "R-HSA-9013508", "R-MMU-1433557", "R-MMU-8984722", "R-HSA-1433557", "R-HSA-6785807", "R-MMU-1169408", "R-HSA-8854691", "R-MMU-877300", "R-HSA-982772", "R-HSA-186763", "R-HSA-8939902", "R-MMU-1059683", "R-HSA-9909649", "R-HSA-909733", "R-HSA-9705462", "R-HSA-877300", "R-MMU-912694", "R-HSA-9860927", "R-HSA-9674555", "R-HSA-8985947", "R-HSA-9020956", "R-MMU-9860927", "R-HSA-1839117"], "pathways": ["R-MMU-8985947:r:Interleukin-9 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-MMU-877300:r:Interferon gamma signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-8985947:r:Interleukin-9 signaling", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR022753": {"description": "Type IV pilus biogenesis PilP", "go_ids": [], "go_terms": [], "name": "T4SS_pilus_biogen_PilP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022754": {"description": "DNA polymerase III, gamma subunit, domain III", "go_ids": ["GO:0003887"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F"], "name": "DNA_pol_III_gamma-3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022755": {"description": "Zinc finger, double-stranded RNA binding", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_jaz", "pathway_ids": ["R-SPO-9770562", "R-HSA-72163", "R-XTR-6782210", "R-MMU-72163", "R-XTR-6782135", "R-HSA-381340", "R-XTR-72163", "R-CEL-72163", "R-XTR-6781823"], "pathways": ["R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-XTR-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-XTR-6782135:r:Dual incision in TC-NER", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex"], "type": "Domain"}, "IPR022756": {"description": "Signal transducer and activation of transcription 2, C-terminal", "go_ids": [], "go_terms": [], "name": "STAT2_C", "pathway_ids": ["R-HSA-9833109", "R-MMU-8854691", "R-HSA-9705671", "R-HSA-909733", "R-HSA-9920588", "R-HSA-912694", "R-SSC-909733", "R-HSA-9679191", "R-SSC-912694", "R-MMU-909733", "R-SSC-8854691", "R-MMU-912694", "R-HSA-8854691"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-SSC-909733:r:Interferon alpha/beta signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SSC-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8854691:r:Interleukin-20 family signaling"], "type": "Domain"}, "IPR022757": {"description": "Glucose signalling factor 2", "go_ids": [], "go_terms": [], "name": "Gsf2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022758": {"description": "ATP-dependent helicase Sgs1", "go_ids": ["GO:0043138", "GO:0003676"], "go_terms": ["GO:0043138:3'-5' DNA helicase activity:F", "GO:0003676:nucleic acid binding:F"], "name": "Helicase_Sgs1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022759": {"description": "Antirestriction protein Ral", "go_ids": [], "go_terms": [], "name": "Antirestriction_protein_Ral", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022761": {"description": "Fumarate lyase-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Fumarate-Lyase-like_N", "pathway_ids": ["PWY-7400", "PWY-4984", "PWY-5", "PWY-4983", "PWY-5154", "R-SPO-73817", "R-DDI-9837999", "R-SPO-70635", "R-MMU-9837999", "R-CEL-9837999", "R-MMU-73817", "R-HSA-70635", "R-SCE-73817", "R-CEL-73817", "R-RNO-9837999", "R-GGA-73817", "R-RNO-70635", "R-DRE-71403", "R-GGA-419140", "R-DRE-9837999", "R-MMU-70635", "R-SPO-71403", "R-CEL-71403", "R-GGA-187630", "R-GGA-421203", "R-SPO-9837999", "R-MMU-71403", "R-SCE-71403", "R-HSA-9956529", "R-SCE-9837999", "R-BTA-70635", "R-HSA-9837999", "R-DDI-71403", "R-RNO-71403", "R-HSA-73817", "R-SCE-70635", "R-HSA-71403"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-4984:t:urea cycle", "PWY-5:t:canavanine biosynthesis", "PWY-4983:t:nitric oxide biosynthesis II (mammals)", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-SPO-70635:r:Urea cycle", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-70635:r:Urea cycle", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-GGA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-70635:r:Urea cycle", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-GGA-419140:r:De novo synthesis of IMP", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-MMU-70635:r:Urea cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-GGA-187630:r:Arginine metabolism", "R-GGA-421203:r:De novo synthesis of AMP", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9956529:r:ASL variants cause argininosuccinate aciduria", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-70635:r:Urea cycle", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-70635:r:Urea cycle", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Domain"}, "IPR022764": {"description": "Peptidase S54, rhomboid domain", "go_ids": ["GO:0004252", "GO:0016020"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0016020:membrane:C"], "name": "Peptidase_S54_rhomboid_dom", "pathway_ids": ["R-DRE-8949664", "R-HSA-8949664", "R-RNO-8949664", "R-HSA-9662834", "R-MMU-8949664"], "pathways": ["R-DRE-8949664:r:Processing of SMDT1", "R-HSA-8949664:r:Processing of SMDT1", "R-RNO-8949664:r:Processing of SMDT1", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-MMU-8949664:r:Processing of SMDT1"], "type": "Domain"}, "IPR022765": {"description": "Dna2/Cas4, domain of unknown function DUF83", "go_ids": [], "go_terms": [], "name": "Dna2/Cas4_DUF83", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022768": {"description": "Fascin-like domain", "go_ids": ["GO:0051015", "GO:0030674"], "go_terms": ["GO:0051015:actin filament binding:F", "GO:0030674:protein-macromolecule adaptor activity:F"], "name": "Fascin-like_dom", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361", "R-HSA-6785807"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling"], "type": "Domain"}, "IPR022770": {"description": "Aerobactin siderophore biosynthesis IucA/IucC-like, C-terminal", "go_ids": [], "go_terms": [], "name": "IucA/IucC-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR022771": {"description": "Wings apart-like protein, C-terminal", "go_ids": [], "go_terms": [], "name": "WAPL_C", "pathway_ids": ["R-HSA-2468052", "R-SPO-2500257", "R-MMU-2500257", "R-SPO-2470946", "R-HSA-2500257", "R-HSA-2467813", "R-DME-2470946", "R-MMU-2467813", "R-CEL-2470946", "R-HSA-2470946", "R-DME-2500257", "R-CEL-2468052", "R-MMU-2468052", "R-MMU-2470946", "R-DME-2468052", "R-CEL-2500257"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-DME-2468052:r:Establishment of Sister Chromatid Cohesion", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion"], "type": "Domain"}, "IPR022773": {"description": "Siva", "go_ids": [], "go_terms": [], "name": "Siva", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022775": {"description": "AP complex, mu/sigma subunit", "go_ids": [], "go_terms": [], "name": "AP_mu_sigma_su", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-SPO-437239", "R-SCE-8856828", "R-XTR-8856825", "R-HSA-9918485", "R-DDI-8856825", "R-HSA-6811434", "R-RNO-177504", "R-HSA-5140745", "R-DDI-8964038", "R-GGA-196025", "R-GGA-5140745", "R-MMU-6811434", "R-DDI-6798695", "R-MMU-196025", "R-BTA-5099900", "R-HSA-432720", "R-HSA-437239", "R-CEL-6807878", "R-MMU-5140745", "R-BTA-177504", "R-HSA-164939", "R-HSA-164940", "R-SPO-8866427", "R-CEL-8964038", "R-SPO-190873", "R-SPO-6811434", "R-SPO-196025", "R-SCE-8866427", "R-CEL-8856825", "R-BTA-6811434", "R-RNO-6798695", "R-GGA-6807878", "R-HSA-190873", "R-CEL-432720", "R-SCE-6798695", "R-DDI-437239", "R-DDI-6811434", "R-BTA-6807878", "R-MMU-190873", "R-SCE-432720", "R-DDI-8866427", "R-MMU-2132295", "R-MMU-8964038", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-BTA-2132295", "R-BTA-8856828", "R-HSA-196025", "R-CEL-8856828", "R-RNO-2132295", "R-HSA-416993", "R-MMU-437239", "R-GGA-8856825", "R-RNO-437239", "R-BTA-432720", "R-HSA-167590", "R-HSA-5099900", "R-GGA-190873", "R-CEL-3928665", "R-HSA-8866427", "R-GGA-8866427", "R-HSA-8856825", "R-HSA-3928665", 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"R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR022812": {"description": "Dynamin", "go_ids": [], "go_terms": [], "name": "Dynamin", "pathway_ids": ["R-MMU-8856828", "R-DDI-169911", "R-DME-190873", "R-BTA-196025", "R-HSA-8856828", "R-HSA-166016", "R-CEL-432722", "R-HSA-9766229", "R-BTA-190873", "R-BTA-75153", "R-RNO-196025", "R-SSC-1169408", "R-DME-3928665", "R-HSA-203641", "R-RNO-432722", "R-SPO-169911", "R-MMU-196025", "R-DME-437239", "R-RNO-432720", "R-MMU-166016", "R-HSA-432720", "R-DME-196025", "R-HSA-437239", "R-BTA-166016", "R-CFA-1169408", "R-HSA-909733", "R-SPO-190873", "R-SCE-196025", "R-HSA-9031628", "R-BTA-1169408", "R-SPO-196025", "R-MMU-9766229", "R-DRE-169911", "R-HSA-2132295", "R-SCE-169911", "R-DME-432720", "R-HSA-190873", "R-CEL-432720", "R-RNO-1169408", "R-MMU-432722", "R-CEL-190873", "R-CEL-437239", "R-RNO-169911", "R-MMU-203641", "R-HSA-1169408", "R-MMU-169911", "R-RNO-75153", "R-MMU-190873", "R-RNO-190873", "R-MMU-2132295", "R-HSA-169911", "R-DME-8856828", "R-BTA-437239", "R-RNO-8856828", "R-HSA-9837999", "R-RNO-203641", "R-MMU-432720", "R-HSA-75153", "R-HSA-432722", "R-BTA-2132295", "R-DRE-75153", "R-HSA-196025", "R-BTA-8856828", "R-SCE-75153", "R-CEL-8856828", "R-RNO-2132295", "R-MMU-437239", "R-RNO-437239", "R-CEL-196025", "R-DME-432722", "R-DDI-75153", "R-MMU-1169408", "R-MMU-75153", "R-CEL-3928665", "R-HSA-177504", "R-CEL-75153", "R-CEL-1169408", "R-HSA-3928665", "R-RNO-9766229", "R-RNO-166016", "R-SPO-75153", "R-PFA-75153", "R-SCE-190873"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DDI-169911:r:Regulation of Apoptosis", "R-DME-190873:r:Gap junction degradation", "R-BTA-196025:r:Formation of annular gap junctions", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-190873:r:Gap junction degradation", "R-BTA-75153:r:Apoptotic execution phase", "R-RNO-196025:r:Formation of annular gap junctions", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-169911:r:Regulation of Apoptosis", "R-MMU-196025:r:Formation of annular gap junctions", "R-DME-437239:r:Recycling pathway of L1", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-196025:r:Formation of annular gap junctions", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CFA-1169408:r:ISG15 antiviral mechanism", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SPO-190873:r:Gap junction degradation", "R-SCE-196025:r:Formation of annular gap junctions", "R-HSA-9031628:r:NGF-stimulated transcription", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-SPO-196025:r:Formation of annular gap junctions", "R-MMU-9766229:r:Degradation of CDH1", "R-DRE-169911:r:Regulation of Apoptosis", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SCE-169911:r:Regulation of Apoptosis", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-190873:r:Gap junction degradation", "R-CEL-437239:r:Recycling pathway of L1", "R-RNO-169911:r:Regulation of Apoptosis", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-169911:r:Regulation of Apoptosis", "R-RNO-75153:r:Apoptotic execution phase", "R-MMU-190873:r:Gap junction degradation", "R-RNO-190873:r:Gap junction degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-169911:r:Regulation of Apoptosis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-75153:r:Apoptotic execution phase", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-DRE-75153:r:Apoptotic execution phase", "R-HSA-196025:r:Formation of annular gap junctions", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-SCE-75153:r:Apoptotic execution phase", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-437239:r:Recycling pathway 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["R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Family"}, "IPR022816": {"description": "Condensin complex subunit 2/barren", "go_ids": ["GO:0000796", "GO:0007076"], "go_terms": ["GO:0000796:condensin complex:C", "GO:0007076:mitotic chromosome condensation:P"], "name": "Condensin_barren_su2", "pathway_ids": ["R-MMU-2514853", "R-HSA-2514853", "R-SCE-2514853", "R-SPO-2514853"], "pathways": ["R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes"], "type": "Family"}, "IPR022818": {"description": "Photosystem I Ycf3, assembly", "go_ids": [], "go_terms": [], "name": "PSI_Ycf3_assembly", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022819": {"description": "Poxvirus Bcl-2-like", "go_ids": [], "go_terms": [], "name": "Poxvirus_Bcl-2-like", "pathway_ids": [], 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{"description": "Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF", "go_ids": ["GO:0009103", "GO:1901505"], "go_terms": ["GO:0009103:lipopolysaccharide biosynthetic process:P", "GO:1901505:carbohydrate derivative transmembrane transporter activity:F"], "name": "Flippase_ArnF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022837": {"description": "Protein-methionine-sulfoxide reductase subunit MsrQ-like", "go_ids": [], "go_terms": [], "name": "MsrQ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022839": {"description": "ArnT", "go_ids": ["GO:0016763"], "go_terms": ["GO:0016763:pentosyltransferase activity:F"], "name": "ArnT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022840": {"description": "GTP cyclohydrolase MptA", "go_ids": ["GO:0003933"], "go_terms": ["GO:0003933:GTP cyclohydrolase activity:F"], "name": "GTP_cyclohydrolase_MptA", "pathway_ids": ["PWY-6797", "PWY-7853"], "pathways": 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genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", 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"PWY-7719", "PWY-6681", "PWY-8461", "PWY-7906", "PWY-7543", "PWY-8253", "PWY-7372", "PWY-8083", "PWY-5979", "PWY-5893", "PWY-7603", "PWY-6403", "PWY-7532", "PWY-6936", "PWY-7605", "PWY-5816", "PWY-7708", "PWY-7659", "PWY-4502", "PWY-7572", "PWY-8080"], "pathways": ["PWY-4681:t:kievitone biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-8389:t:penigequinolone biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-7998:t:menaquinol-4 biosynthesis II", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-8442:t:hyperxanthone E biosynthesis", "PWY-5802:t:alizarin biosynthesis", "PWY-7493:t:paxilline and diprenylpaxilline biosynthesis", "PWY-5815:t:rubber biosynthesis", "PWY-5817:t:dodecaprenyl diphosphate biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7540:t:aflatrem biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", 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biosynthesis", "PWY-5816:t:all trans undecaprenyl diphosphate biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-4502:t:wighteone and luteone biosynthesis", "PWY-7572:t:lolitrem B biosynthesis", "PWY-8080:t:kainate biosynthesis"], "type": "Family"}, "IPR022859": {"description": "Alginate lyase", "go_ids": ["GO:0042122", "GO:0045135", "GO:0042597"], "go_terms": ["GO:0042122:alginic acid catabolic process:P", "GO:0045135:poly(beta-D-mannuronate) lyase activity:F", "GO:0042597:periplasmic space:C"], "name": "Alginate_lyase", "pathway_ids": ["PWY-6986"], "pathways": ["PWY-6986:t:alginate degradation"], "type": "Family"}, "IPR022867": {"description": "Protein-methionine-sulfoxide reductase subunit MsrP", "go_ids": ["GO:0016667", "GO:0030091", "GO:0043546"], "go_terms": ["GO:0016667:oxidoreductase activity, acting on a sulfur group of donors:F", "GO:0030091:protein repair:P", "GO:0043546:molybdopterin cofactor binding:F"], "name": "MsrP", 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"type": "Family"}, "IPR022877": {"description": "Protein of unknown funcion UPF0173", "go_ids": [], "go_terms": [], "name": "UPF0173", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022878": {"description": "V-type ATP synthase catalytic alpha chain", "go_ids": ["GO:0046961", "GO:0046034"], "go_terms": ["GO:0046961:proton-transporting ATPase activity, rotational mechanism:F", "GO:0046034:ATP metabolic process:P"], "name": "V-ATPase_asu", "pathway_ids": ["PWY-7980", "R-MMU-1222556", "R-CEL-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-HSA-9639288", "R-PFA-917977", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-SCE-917977", "R-SCE-1222556", "R-MMU-77387", "R-BTA-1222556", "R-DDI-9639288", "R-SCE-77387", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-PFA-1222556", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-HSA-917977", "R-MMU-983712", "R-DDI-983712", "R-DDI-917977", "R-BTA-77387", "R-PFA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["PWY-7980:t:ATP biosynthesis", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-PFA-917977:r:Transferrin endocytosis and recycling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-MMU-77387:r:Insulin receptor recycling", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-SCE-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-PFA-1222556:r:ROS and RNS production in phagocytes", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-BTA-77387:r:Insulin receptor recycling", "R-PFA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR022879": {"description": "V-type ATP synthase regulatory subunit B/beta", "go_ids": [], "go_terms": [], "name": "V-ATPase_su_B/beta", "pathway_ids": ["R-MMU-1222556", "R-CEL-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-RNO-1222556", "R-HSA-9639288", "R-RNO-983712", "R-HSA-1222556", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-RNO-917977", "R-SCE-1222556", "R-SCE-917977", "R-MMU-77387", "R-BTA-1222556", "R-DDI-9639288", "R-SCE-77387", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-RNO-77387", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-RNO-9639288", "R-HSA-917977", "R-MMU-983712", "R-DDI-917977", "R-DDI-983712", "R-BTA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-RNO-983712:r:Ion channel transport", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-MMU-77387:r:Insulin receptor recycling", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-SCE-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-RNO-77387:r:Insulin receptor recycling", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-DDI-983712:r:Ion channel transport", "R-BTA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR022881": {"description": "Ribosomal RNA large subunit methyltransferase, Cfr", "go_ids": ["GO:0070475"], "go_terms": ["GO:0070475:rRNA base methylation:P"], "name": "rRNA_lsu_MeTfrase_Cfr", "pathway_ids": ["PWY-6828"], "pathways": ["PWY-6828:t:linezolid resistance"], "type": "Family"}, "IPR022885": {"description": "NAD(P)H-quinone oxidoreductase subunit D/H", "go_ids": ["GO:0016651"], "go_terms": ["GO:0016651:oxidoreductase activity, acting on NAD(P)H:F"], "name": "NDH1_su_D/H", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-CEL-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198", "R-MMU-611105", "R-BTA-6799198", "R-DDI-6799198", "R-BTA-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-CEL-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR022893": {"description": "Shikimate dehydrogenase family", "go_ids": ["GO:0004764"], "go_terms": ["GO:0004764:shikimate 3-dehydrogenase (NADP+) activity:F"], "name": "Shikimate_DH_fam", "pathway_ids": ["PWY-6163"], "pathways": ["PWY-6163:t:chorismate biosynthesis from 3-dehydroquinate"], "type": "Family"}, "IPR022894": {"description": "Oligoribonuclease", "go_ids": ["GO:0000175"], "go_terms": ["GO:0000175:3'-5'-RNA exonuclease activity:F"], "name": "Oligoribonuclease", "pathway_ids": ["R-HSA-9836573"], "pathways": ["R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Family"}, "IPR022898": {"description": "Ribonuclease HII", "go_ids": ["GO:0004523"], "go_terms": ["GO:0004523:RNA-DNA hybrid ribonuclease activity:F"], "name": "RNase_HII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022902": {"description": "N-acetyltransferase Eis", "go_ids": [], "go_terms": [], "name": "NAcTrfase_Eis", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-9636569"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-9636569:r:Suppression of autophagy"], "type": "Family"}, "IPR022924": {"description": "Cardiolipin synthase", "go_ids": ["GO:0016780", "GO:0032049", "GO:0008808"], "go_terms": ["GO:0016780:phosphotransferase activity, for other substituted phosphate groups:F", "GO:0032049:cardiolipin biosynthetic process:P", "GO:0008808:cardiolipin synthase activity:F"], "name": "Cardiolipin_synthase", "pathway_ids": ["PWY-6580", "PWY-6350", "PWY-7817", "PWY-7981", "PWY-7819", "PWY-6804", "PWY-7820", "PWY-8248", "PWY-7816", "PWY-7818", "PWY-7815"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-6350:t:archaetidylinositol biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-6804:t:diacylglycerol biosynthesis (PUFA enrichment in oilseed)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"], "type": "Family"}, "IPR022927": {"description": "RNA pyrophosphohydrolase RppH", "go_ids": [], "go_terms": [], "name": "RppH", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR022930": {"description": "Protein of unknown function UPF0316", "go_ids": [], "go_terms": [], "name": "UPF0316", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022932": {"description": "Putative phosphoesterase YjcG", "go_ids": [], "go_terms": [], "name": "YjcG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022935": {"description": "ATP-dependent Clp protease adaptor protein ClpS", "go_ids": ["GO:0006508"], "go_terms": ["GO:0006508:proteolysis:P"], "name": "ClpS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022941": {"description": "Signal recognition particle, SRP54 subunit", "go_ids": ["GO:0006614", "GO:0048500", "GO:0005525", "GO:0003924"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P", "GO:0048500:signal recognition particle:C", "GO:0005525:GTP binding:F", "GO:0003924:GTPase activity:F"], "name": "SRP54", "pathway_ids": ["R-HSA-1799339", "R-DRE-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-RNO-1799339", "R-BTA-1799339", "R-MMU-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR022946": {"description": "Uncharacterised protein family UPF0313", "go_ids": [], "go_terms": [], "name": "UPF0313", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022947": {"description": "Large ribosomal subunit protein eL18, archaea", "go_ids": [], "go_terms": [], "name": "Ribosomal_eL18_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022968": {"description": "16S/18S rRNA aminocarboxypropyltransferase Tsr3", "go_ids": ["GO:0006364", "GO:0016740", "GO:0106388"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0016740:transferase activity:F", "GO:0106388:rRNA small subunit aminocarboxypropyltransferase activity:F"], "name": "Tsr3-like", "pathway_ids": ["PWY-8341", "R-HSA-6790901"], "pathways": ["PWY-8341:t:N1-methyl-N3-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR022973": {"description": "Large ribosomal subunit protein uL10, bacteria", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL10_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022980": {"description": "Photosystem I, reaction centre subunit XI", "go_ids": [], "go_terms": [], "name": "PSI_suXI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022985": {"description": "Sulfate transporter CysZ", "go_ids": ["GO:0015116", "GO:0000103", "GO:0005886"], "go_terms": ["GO:0015116:sulfate transmembrane transporter activity:F", "GO:0000103:sulfate assimilation:P", "GO:0005886:plasma membrane:C"], "name": "Sulfate_CysZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022986": {"description": "Uncharacterised protein family UPF0237, ACT-type", "go_ids": [], "go_terms": [], "name": "UPF0237_ACT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022987": {"description": "Uncharacterised protein family UPF0227", "go_ids": [], "go_terms": [], "name": "UPF0227", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022990": {"description": "Ribosome rescue factor SmrB", "go_ids": [], "go_terms": [], "name": "SmrB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR022998": {"description": "Thiamine phosphate synthase/TenI", "go_ids": [], "go_terms": [], "name": "ThiamineP_synth_TenI", "pathway_ids": ["PWY-8457", "PWY-6894", "PWY-6908", "PWY-6907", "PWY-7356", "PWY-6897", "PWY-6893"], "pathways": ["PWY-8457:t:thiamine diphosphate salvage V", "PWY-6894:t:thiamine diphosphate biosynthesis I (E. coli)", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "PWY-6897:t:thiamine diphosphate salvage II", "PWY-6893:t:thiamine diphosphate biosynthesis II (Bacillus)"], "type": "Domain"}, "IPR023010": {"description": "Probable glycine dehydrogenase (decarboxylating) subunit 1", "go_ids": ["GO:0004375", "GO:0009116"], "go_terms": ["GO:0004375:glycine dehydrogenase (decarboxylating) activity:F", "GO:0009116:nucleoside metabolic process:P"], "name": "GcvPA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023017": {"description": "Transport protein YbjL, putative", "go_ids": [], "go_terms": [], "name": "Transp_YbjL_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023025": {"description": "Serine/threonine transporter SstT", "go_ids": ["GO:0015826", "GO:0032329", "GO:0015293"], "go_terms": ["GO:0015826:threonine transport:P", "GO:0032329:serine transport:P", "GO:0015293:symporter activity:F"], "name": "Ser_Thr_transp_SstT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023026": {"description": "Tryptophan synthase beta chain/beta chain-like", "go_ids": ["GO:0004834", "GO:0000162"], "go_terms": ["GO:0004834:tryptophan synthase activity:F", "GO:0000162:L-tryptophan biosynthetic process:P"], "name": "Trp_synth_beta/beta-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023029": {"description": "Small ribosomal subunit protein uS15, archaea/eukaryota", "go_ids": [], "go_terms": [], "name": "Ribosomal_uS15_arc_euk", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-DME-6791226", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-HSA-72695", "R-DME-72706", "R-RNO-72695", "R-MMU-72706", "R-HSA-975956", "R-BTA-72689", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-CEL-72706", "R-BTA-72695", "R-GGA-72706", "R-CEL-9954716", "R-CEL-9954714", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-SPO-975956", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-DDI-72695", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-GGA-9954716", "R-CEL-156827", "R-RNO-72649", "R-RNO-6791226", "R-GGA-72649", "R-HSA-6791226", "R-RNO-975956", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-GGA-72695", "R-CEL-72689", "R-SPO-72689", "R-MMU-1799339", "R-DDI-72702", "R-DDI-72689", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-GGA-72702", "R-GGA-975956", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-GGA-9954714", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-SCE-156827", "R-DME-72695", "R-MMU-72702", "R-DME-975956", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-HSA-72649", "R-MMU-156827", "R-HSA-9754678", "R-SPO-6791226", "R-BTA-1799339", "R-BTA-9954714", "R-GGA-975957", "R-SCE-72649", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-GGA-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and 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"R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger 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"R-HSA-2467813", "R-HSA-3108214", "R-SPO-2470946", "R-BTA-2468052", "R-MMU-2467813", "R-HSA-2470946", "R-HSA-1221632", "R-SCE-2500257", "R-BTA-3108214", "R-BTA-2467813", "R-BTA-2500257", "R-MMU-2470946", "R-MMU-3108214", "R-MMU-2468052", "R-HSA-9018519", "R-BTA-2470946"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-BTA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-1221632:r:Meiotic synapsis", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-BTA-2470946:r:Cohesin Loading onto Chromatin"], "type": "Homologous_superfamily"}, "IPR023095": {"description": "Adenine-specific methyltransferase, domain 2", "go_ids": ["GO:0009007"], "go_terms": ["GO:0009007:site-specific DNA-methyltransferase (adenine-specific) activity:F"], "name": "Ade_MeTrfase_dom_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023096": {"description": "Phosphoglucose isomerase, C-terminal", "go_ids": ["GO:0004347", "GO:0006096"], "go_terms": ["GO:0004347:glucose-6-phosphate isomerase activity:F", "GO:0006096:glycolytic process:P"], "name": "G6P_Isomerase_C", "pathway_ids": ["PWY-7385", "PWY-5659", "PWY-5514", "PWY-6142", "PWY-7238", "PWY-622", "PWY-621", "PWY-6992", "PWY-7347", "PWY-6981", "PWY-5384", "PWY-8013", "PWY-3801", "PWY-5054", "R-RNO-6798695", "R-HSA-6798695", "R-DDI-6798695", "R-MMU-70171", "R-SSC-6798695", "R-SPO-6798695", "R-DDI-5628897", "R-RNO-70263", "R-SCE-70171", "R-SCE-5628897", "R-SSC-70263", "R-SPO-5628897", "R-DME-6798695", "R-SSC-5628897", "R-BTA-70171", "R-SCE-6798695", "R-DME-70171", "R-RNO-5628897", "R-BTA-6798695", "R-MMU-70263", "R-DDI-70171", "R-HSA-5628897", "R-DME-70263", "R-DDI-70263", "R-BTA-5628897", "R-RNO-70171", "R-SSC-70171", "R-HSA-70263", "R-BTA-70263", "R-MMU-5628897", "R-SCE-70263", "R-MMU-6798695", "R-DME-5628897", "R-HSA-70171", "R-SPO-70171", "R-SPO-70263"], "pathways": ["PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5659:t:GDP-mannose biosynthesis", "PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-7238:t:sucrose biosynthesis II", "PWY-622:t:starch biosynthesis", "PWY-621:t:sucrose degradation III (sucrose invertase)", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7347:t:sucrose biosynthesis III", "PWY-6981:t:chitin biosynthesis", "PWY-5384:t:sucrose degradation IV (sucrose phosphorylase)", "PWY-8013:t:UDP-N-acetyl-D-galactosamine biosynthesis III", "PWY-3801:t:sucrose degradation II (sucrose synthase)", "PWY-5054:t:D-sorbitol biosynthesis I", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-70171:r:Glycolysis", "R-SSC-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-70263:r:Gluconeogenesis", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-6798695:r:Neutrophil degranulation", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-70171:r:Glycolysis", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-70171:r:Glycolysis", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-70263:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-70171:r:Glycolysis", "R-SSC-70171:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-70263:r:Gluconeogenesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR023098": {"description": "L-serine kinase SerK/SbnI, C-terminal", "go_ids": [], "go_terms": [], "name": "SerK/SbnI_C", "pathway_ids": ["PWY-7694", "PWY-8381", "PWY-8008", "PWY-7706"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-8381:t:sulfazecin biosynthesis", "PWY-8008:t:staphyloferrin B biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Homologous_superfamily"}, "IPR023099": {"description": "Glycoside hydrolase, family 46, N-terminal", "go_ids": ["GO:0005975", "GO:0016977"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016977:chitosanase activity:F"], "name": "Glyco_hydro_46_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023100": {"description": "D-aminoacylase, insert domain superfamily", "go_ids": ["GO:0016811"], "go_terms": ["GO:0016811:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides:F"], "name": "D-aminoacylase_insert_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023101": {"description": "AF1862-like domain superfamily", "go_ids": [], "go_terms": [], "name": "AF1862-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023104": {"description": "ITPase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "ITPase-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023105": {"description": "YkvR-like superfamily", "go_ids": [], "go_terms": [], "name": "YkvR-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023107": {"description": "Atu2299-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Atu2299-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023108": {"description": "Domain of unknown function, DUF3216", "go_ids": [], "go_terms": [], "name": "DUF3216", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023110": {"description": "PH1570-like domain", "go_ids": [], "go_terms": [], "name": "PH1570-like_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023111": {"description": "Titin-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Titin-like_dom_sf", "pathway_ids": ["R-MMU-390522", "R-BTA-390522", "R-HSA-390522"], "pathways": ["R-MMU-390522:r:Striated Muscle Contraction", "R-BTA-390522:r:Striated Muscle Contraction", "R-HSA-390522:r:Striated Muscle Contraction"], "type": "Homologous_superfamily"}, "IPR023112": {"description": "Antifungal protein domain superfamily", "go_ids": [], "go_terms": [], "name": "Antifungal-protein_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023113": {"description": "Telomere-binding protein, beta subunit domain superfamily", "go_ids": [], "go_terms": [], "name": "TEBP_beta_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023115": {"description": "Translation initiation factor IF- 2, domain 3", "go_ids": [], "go_terms": [], "name": "TIF_IF2_dom3", "pathway_ids": ["R-HSA-72706", "R-DDI-72706", "R-SPO-72706", "R-HSA-5368286", "R-RNO-72706", "R-SCE-72706", "R-MMU-72706"], "pathways": ["R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit"], "type": "Domain"}, "IPR023116": {"description": "Phosphonoacetate hydrolase, insert domain superfamily", "go_ids": [], "go_terms": [], "name": "Phosphonoacetate_hydro_insert", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023117": {"description": "PA1123-like domain", "go_ids": [], "go_terms": [], "name": "PA1123-like_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023118": {"description": "YqaI domain superfamily", "go_ids": [], "go_terms": [], "name": "YqaI_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023119": {"description": "Multihaem cytochrome, PRC subunit superfamily", "go_ids": [], "go_terms": [], "name": "Multihaem_cyt_PRC_cyt_su-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023120": {"description": "Winged helix-turn-helix transcription repressor, HrcA, inserted dimerising domain superfamily", "go_ids": [], "go_terms": [], "name": "WHTH_transcript_rep_HrcA_IDD", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023121": {"description": "ApoC-II domain superfamily", "go_ids": [], "go_terms": [], "name": "ApoC-II_dom_sf", "pathway_ids": ["R-RNO-8963901", "R-MMU-8963888", "R-CFA-8963888", "R-CFA-975634", "R-HSA-8963889", "R-HSA-8964058", "R-BTA-8963901", "R-HSA-8963901", "R-HSA-8963888", "R-BTA-975634", "R-BTA-8963888", "R-MMU-8963901", "R-MMU-8964058", "R-RNO-8963888", "R-CFA-8963901", "R-MMU-975634", "R-RNO-975634", "R-HSA-9029569", "R-RNO-8964058", "R-HSA-975634", "R-BTA-8964058"], "pathways": ["R-RNO-8963901:r:Chylomicron remodeling", "R-MMU-8963888:r:Chylomicron assembly", "R-CFA-8963888:r:Chylomicron assembly", "R-CFA-975634:r:Retinoid metabolism and transport", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8964058:r:HDL remodeling", "R-BTA-8963901:r:Chylomicron remodeling", "R-HSA-8963901:r:Chylomicron remodeling", "R-HSA-8963888:r:Chylomicron assembly", "R-BTA-975634:r:Retinoid metabolism and transport", "R-BTA-8963888:r:Chylomicron assembly", "R-MMU-8963901:r:Chylomicron remodeling", "R-MMU-8964058:r:HDL remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-CFA-8963901:r:Chylomicron remodeling", "R-MMU-975634:r:Retinoid metabolism and transport", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-8964058:r:HDL remodeling", "R-HSA-975634:r:Retinoid metabolism and transport", "R-BTA-8964058:r:HDL remodeling"], "type": "Homologous_superfamily"}, "IPR023122": {"description": "NE1680-like superfamily", "go_ids": [], "go_terms": [], "name": "NE1680-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023123": {"description": "Tubulin, C-terminal", "go_ids": [], "go_terms": [], "name": "Tubulin_C", "pathway_ids": ["R-RNO-190840", "R-HSA-9646399", "R-SSC-3371497", "R-HSA-9833482", "R-XTR-190840", "R-MMU-9668328", "R-RNO-5610787", "R-MMU-68877", "R-DDI-114608", "R-HSA-9668328", "R-MMU-380320", "R-SSC-5620924", "R-SSC-9833482", "R-HSA-6811434", "R-SSC-2132295", "R-XTR-6811434", "R-BTA-2565942", "R-MMU-5610787", "R-RNO-380284", "R-BTA-2500257", "R-SSC-2565942", "R-MMU-5620912", "R-MMU-6811434", "R-DDI-6798695", "R-SSC-8854518", "R-HSA-5620924", "R-MMU-9013407", "R-MMU-380259", "R-XTR-6807878", "R-RNO-9013407", "R-HSA-437239", "R-CEL-6807878", "R-MMU-380270", "R-SSC-5620920", "R-HSA-9609690", "R-CEL-5620924", "R-RNO-5663220", "R-XTR-380320", "R-RNO-6811436", "R-MMU-9646399", "R-BTA-6811436", "R-HSA-8955332", "R-SSC-6807878", "R-HSA-1445148", "R-HSA-389960", "R-RNO-5620924", "R-HSA-389957", "R-BTA-9648025", "R-HSA-9609736", "R-RNO-380270", "R-MMU-5663220", "R-MMU-3371497", "R-RNO-6798695", "R-GGA-6807878", "R-GGA-9646399", "R-DDI-9668328", "R-SSC-6798695", "R-HSA-2467813", "R-MMU-8852276", "R-SCE-6798695", "R-MMU-983189", "R-RNO-3371497", "R-MMU-5620920", "R-HSA-3371497", "R-SSC-5626467", "R-MMU-380284", "R-HSA-114608", "R-BTA-6807878", "R-SSC-5610787", "R-RNO-2565942", "R-HSA-68877", "R-MMU-8955332", "R-MMU-2132295", "R-BTA-380320", "R-XTR-9668328", "R-BTA-2132295", "R-HSA-6811436", "R-SSC-9668328", "R-SSC-9648025", "R-DDI-9833482", "R-GGA-3371497", "R-MMU-437239", "R-DDI-5610787", "R-RNO-2132295", "R-MMU-5626467", "R-DME-6811436", "R-RNO-437239", "R-RNO-68877", "R-XTR-9648025", "R-DME-6798695", "R-RNO-5626467", "R-HSA-380270", "R-XTR-8852276", "R-RNO-380259", "R-XTR-9646399", "R-RNO-9646399", "R-HSA-5663220", "R-RNO-9648025", "R-XTR-8854518", "R-RNO-9833482", "R-XTR-8955332", "R-SSC-5620912", "R-HSA-6798695", "R-SSC-5663220", "R-HSA-190861", "R-RNO-983189", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-BTA-6798695", "R-SSC-190840", "R-HSA-8854518", "R-DDI-5626467", "R-MMU-2565942", "R-RNO-380320", "R-BTA-380259", "R-HSA-380320", "R-MMU-9833482", "R-SSC-9013407", "R-XTR-3371497", "R-GGA-9648025", "R-BTA-5620912", "R-HSA-389977", "R-DME-6807878", "R-MMU-5620924", "R-BTA-9013407", "R-SSC-380259", "R-PFA-9646399", "R-XTR-5620920", "R-HSA-9648025", "R-DDI-8955332", "R-XTR-6798695", "R-XTR-380259", "R-MMU-6811436", "R-GGA-5620924", "R-SSC-380284", "R-HSA-5620920", "R-MMU-8854518", "R-MMU-6798695", "R-BTA-3371497", "R-RNO-2467813", "R-BTA-9646399", "R-GGA-983189", "R-BTA-5620924", "R-XTR-114608", "R-SSC-983189", "R-HSA-9013407", "R-MMU-114608", "R-RNO-9668328", "R-SSC-9646399", "R-SSC-6811434", "R-SPO-6798695", "R-HSA-2132295", "R-SSC-380270", "R-HSA-9619483", "R-HSA-190840", "R-HSA-5626467", "R-RNO-2500257", "R-DDI-5620920", "R-XTR-2467813", "R-SSC-68877", "R-XTR-380270", "R-MMU-6807878", "R-RNO-5620912", "R-GGA-2500257", "R-RNO-114608", "R-HSA-2565942", "R-BTA-114608", "R-BTA-2467813", "R-XTR-5620912", "R-HSA-5610787", "R-SSC-8955332", "R-RNO-8852276", "R-GGA-2467813", "R-MMU-9648025", "R-HSA-5620912", "R-BTA-380284", "R-PFA-3371497", "R-MMU-2500257", "R-GGA-6811436", "R-MMU-190840", "R-HSA-2500257", "R-RNO-6811434", "R-RNO-8854518", "R-RNO-6807878", "R-HSA-6807878", "R-HSA-8852276", "R-CEL-6811436", "R-XTR-5663220", "R-RNO-5620920", "R-HSA-9679191", "R-XTR-380284", "R-XTR-68877", "R-SSC-8852276", "R-SSC-2467813", "R-XTR-983189", "R-BTA-8854518", "R-BTA-380270", "R-DDI-6807878", "R-HSA-983189", "R-XTR-5620924", "R-XTR-2565942", "R-PFA-6798695", "R-SSC-380320", "R-PFA-5620920", "R-RNO-8955332", "R-SSC-2500257", "R-HSA-380259", "R-XTR-2500257", "R-PFA-8955332", "R-GGA-6811434"], "pathways": ["R-RNO-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-9646399:r:Aggrephagy", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9833482:r:PKR-mediated signaling", "R-XTR-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-DDI-114608:r:Platelet degranulation", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", 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"Trans_acon_MeTrfase_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023153": {"description": "Dual-action ribosomal maturation protein DarP superfamily", "go_ids": [], "go_terms": [], "name": "DarP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023154": {"description": "Jann4075-like superfamily", "go_ids": [], "go_terms": [], "name": "Jann4075-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023155": {"description": "Cytochrome c-552/4", "go_ids": [], "go_terms": [], "name": "Cyt_c-552/4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023157": {"description": "AGR-C-984p-like superfamily", "go_ids": [], "go_terms": [], "name": "AGR-C-984p-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023158": {"description": "YerB-like superfamily", "go_ids": [], "go_terms": [], "name": "YerB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023159": {"description": "SO1590-like superfamily", "go_ids": [], "go_terms": [], "name": "SO1590-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023160": {"description": "Ribonuclease HII, helix-loop-helix cap domain superfamily", "go_ids": ["GO:0004523"], "go_terms": ["GO:0004523:RNA-DNA hybrid ribonuclease activity:F"], "name": "RNase_HII_hlx-loop-hlx_cap_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023162": {"description": "Apc36109-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Apc36109-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023163": {"description": "SMc04008-like domain", "go_ids": [], "go_terms": [], "name": "SMc04008-like_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023164": {"description": "YqgQ-like superfamily", "go_ids": [], "go_terms": [], "name": "YqgQ-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023165": {"description": "rRNA adenine dimethylase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "rRNA_Ade_diMease-like_C", "pathway_ids": ["R-SCE-163282", "R-HSA-6793080", "R-SPO-163282", "R-HSA-2151201"], "pathways": ["R-SCE-163282:r:Mitochondrial transcription initiation", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-SPO-163282:r:Mitochondrial transcription initiation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis"], "type": "Homologous_superfamily"}, "IPR023166": {"description": "BaiN-like, insert domain superfamily", "go_ids": [], "go_terms": [], "name": "BaiN-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023167": {"description": "Yap1 redox domain superfamily", "go_ids": [], "go_terms": [], "name": "Yap1_redox_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023168": {"description": "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2", "go_ids": [], "go_terms": [], "name": "GatB_Yqey_C_2", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Homologous_superfamily"}, "IPR023170": {"description": "Helix-hairpin-helix, base-excision DNA repair, C-terminal", "go_ids": [], "go_terms": [], "name": "HhH_base_excis_C", "pathway_ids": ["R-HSA-110357", "R-MMU-5649702", "R-HSA-9656256", "R-SCE-110329", "R-DME-110357", "R-HSA-5649702", "R-MMU-110331", "R-CEL-110329", "R-HSA-110331", "R-HSA-9657050", "R-BTA-110357", "R-MMU-110329", "R-HSA-110329", "R-RNO-110330", "R-HSA-110330", "R-CEL-110357", "R-DME-110330", "R-SPO-110331", "R-MMU-110357", "R-HSA-9630222", "R-HSA-9656255", "R-SCE-110330", "R-MMU-110330", "R-DME-110329", "R-HSA-9608287", "R-RNO-110331", "R-HSA-110328", "R-HSA-9608290", "R-RNO-110357", "R-BTA-110329", "R-DME-110331", "R-RNO-5649702", "R-SPO-110329", "R-SCE-110331", "R-RNO-110329", "R-HSA-9630221"], "pathways": ["R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-9656256:r:Defective OGG1 Substrate Processing", "R-SCE-110329:r:Cleavage of the damaged pyrimidine", "R-DME-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110331:r:Cleavage of the damaged purine", "R-CEL-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-9657050:r:Defective OGG1 Localization", "R-BTA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-CEL-110357:r:Displacement of DNA glycosylase by APEX1", "R-DME-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-SPO-110331:r:Cleavage of the damaged purine", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9630222:r:Defective NTHL1 substrate binding", "R-HSA-9656255:r:Defective OGG1 Substrate Binding", "R-SCE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-DME-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-9608287:r:Defective MUTYH substrate binding", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9608290:r:Defective MUTYH substrate processing", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-BTA-110329:r:Cleavage of the damaged pyrimidine", "R-DME-110331:r:Cleavage of the damaged purine", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-SPO-110329:r:Cleavage of the damaged pyrimidine", "R-SCE-110331:r:Cleavage of the damaged purine", "R-RNO-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-9630221:r:Defective NTHL1 substrate processing"], "type": "Homologous_superfamily"}, "IPR023171": {"description": "Na+/H+ antiporter domain superfamily", "go_ids": [], "go_terms": [], "name": "Na/H_antiporter_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023173": {"description": "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "NADPH_Cyt_P450_Rdtase_alpha", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-MMU-1222556", "R-SSC-9033241", "R-DME-1222556", "R-RNO-9009391", "R-DDI-5578775", "R-MMU-9009391", "R-HSA-1614635", "R-RNO-5218920", "R-HSA-203615", "R-RNO-9033241", "R-HSA-5218920", "R-SPO-9009391", "R-DDI-5218920", "R-RNO-1474151", "R-SCE-9033241", "R-MMU-392154", "R-SPO-1222556", "R-RNO-156581", "R-MMU-1614635", "R-HSA-3359467", "R-DDI-9033241", "R-HSA-203641", "R-SCE-9856530", "R-RNO-203754", "R-SCE-1222556", "R-HSA-9636249", "R-SPO-392154", "R-MMU-5578775", "R-SPO-5218920", "R-SCE-1474151", "R-HSA-6785807", "R-SSC-392154", "R-MMU-156581", "R-HSA-211897", "R-SCE-5578775", "R-DDI-203615", "R-DME-5218920", "R-RNO-203615", "R-HSA-203754", "R-DDI-9856530", "R-MMU-203754", "R-DME-203754", "R-SCE-203615", "R-DME-1474151", "R-HSA-9759218", "R-DDI-392154", "R-DME-9856530", "R-MMU-9856530", "R-HSA-1474151", "R-HSA-392154", "R-DDI-9009391", "R-SPO-1474151", "R-RNO-9759218", "R-MMU-203615", "R-RNO-1222556", "R-MMU-203641", "R-SCE-392154", "R-RNO-392154", "R-HSA-1222556", "R-DME-9009391", "R-MMU-9759218", "R-HSA-5578775", "R-DDI-1222556", "R-RNO-203641", "R-SPO-5578775", "R-SPO-9856530", "R-SSC-1222556", "R-HSA-2564830", "R-DDI-1474151", "R-MMU-5218920", "R-CEL-9759218", "R-DME-392154", "R-RNO-5578775", "R-DME-5578775", "R-DME-9033241", "R-SCE-9009391", "R-MMU-9033241", "R-DME-203615", "R-MMU-1474151", "R-HSA-3359469", "R-SPO-203615", "R-CEL-1614635", "R-RNO-9856530", "R-HSA-9009391", "R-SPO-9033241", "R-DDI-203754", "R-HSA-156581", "R-HSA-9856530", "R-HSA-9033241", "R-SCE-5218920"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-9033241:r:Peroxisomal protein import", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-5578775:r:Ion homeostasis", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-203615:r:eNOS activation", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SCE-9033241:r:Peroxisomal protein import", "R-MMU-392154:r:Nitric oxide stimulates guanylate cyclase", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-156581:r:Methylation", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-203754:r:NOSIP mediated eNOS trafficking", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-SPO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-5578775:r:Ion homeostasis", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-156581:r:Methylation", "R-HSA-211897:r:Cytochrome P450 - arranged by substrate type", "R-SCE-5578775:r:Ion homeostasis", "R-DDI-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-203615:r:eNOS activation", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-DME-203754:r:NOSIP mediated eNOS trafficking", "R-SCE-203615:r:eNOS activation", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-DDI-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-203615:r:eNOS activation", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-SCE-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-5578775:r:Ion homeostasis", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-SPO-5578775:r:Ion homeostasis", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-DME-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-5578775:r:Ion homeostasis", "R-DME-5578775:r:Ion homeostasis", "R-DME-9033241:r:Peroxisomal protein import", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9033241:r:Peroxisomal protein import", "R-DME-203615:r:eNOS activation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-SPO-203615:r:eNOS activation", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-9033241:r:Peroxisomal protein import", "R-DDI-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-156581:r:Methylation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9033241:r:Peroxisomal protein import", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Homologous_superfamily"}, "IPR023175": {"description": "Vta1/Callose synthase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Vta1/CALS_N_sf", "pathway_ids": ["R-HSA-917729", "R-HSA-162588", "R-DDI-917729", "R-MMU-917729"], "pathways": ["R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Homologous_superfamily"}, "IPR023176": {"description": "Orbivirus inner capsid protein VP7, N-terminal", "go_ids": [], "go_terms": [], "name": "Orbi_VP7_capsid_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023178": {"description": "Orbivirus inner capsid protein VP7, C-terminal", "go_ids": [], "go_terms": [], "name": "Orbi_VP7_capsid_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023179": {"description": "GTP-binding protein, orthogonal bundle domain superfamily", "go_ids": [], "go_terms": [], "name": "GTP-bd_ortho_bundle_sf", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-DDI-6791226", "R-DRE-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Homologous_superfamily"}, "IPR023180": {"description": "Tetrahydrodipicolinate-N-succinyltransferase, chain A, domain 1", "go_ids": [], "go_terms": [], "name": "THP_succinylTrfase_dom1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023181": {"description": "Homospermidine synthase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Homospermid_syn-like_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023183": {"description": "Serine protease, chymotrypsin-like serine protease, C-terminal", "go_ids": [], "go_terms": [], "name": "Chymotrypsin-like_C", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR023184": {"description": "Ubiquinol-cytochrome C reductase hinge domain", "go_ids": [], "go_terms": [], "name": "Ubol_cytC_Rdtase_hinge_dom", "pathway_ids": ["R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-HSA-9865881", "R-DDI-611105", "R-MMU-611105", "R-SPO-611105", "R-BTA-9865881", "R-RNO-9865881", "R-SCE-611105", "R-BTA-611105", "R-MMU-9865881"], "pathways": ["R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-9865881:r:Complex III assembly", "R-DDI-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-BTA-9865881:r:Complex III assembly", "R-RNO-9865881:r:Complex III assembly", "R-SCE-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR023186": {"description": "Inosine/uridine-preferring nucleoside hydrolase", "go_ids": [], "go_terms": [], "name": "IUNH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023191": {"description": "Deoxynucleotide monophosphate kinase, N-terminal", "go_ids": [], "go_terms": [], "name": "DNMP_kinase_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023192": {"description": "TGS-like domain superfamily", "go_ids": [], "go_terms": [], "name": "TGS-like_dom_sf", "pathway_ids": ["R-HSA-114608", "R-BTA-114608", "R-DRE-114608", "R-DME-114608", "R-CEL-114608", "R-SCE-114608", "R-GGA-114608", "R-SPO-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-DME-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-SCE-114608:r:Platelet degranulation", "R-GGA-114608:r:Platelet degranulation", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR023194": {"description": "Eukaryotic translation initiation factor 3-like domain superfamily", "go_ids": [], "go_terms": [], "name": "eIF3-like_dom_sf", "pathway_ids": ["R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-DME-72649", "R-HSA-156827", "R-XTR-72702", "R-RNO-72689", "R-GGA-72702", "R-MMU-72649", "R-HSA-72695", "R-RNO-72695", "R-BTA-72689", "R-MMU-72706", "R-SPO-72689", "R-BTA-72695", "R-SCE-72695", "R-MMU-72695", "R-SCE-72702", "R-XTR-72695", "R-DRE-156827", "R-SCE-156827", "R-BTA-156827", "R-MMU-72702", "R-DME-72695", "R-RNO-156827", "R-DRE-72695", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-XTR-156827", "R-BTA-72702", "R-DME-72689", "R-RNO-72702", "R-HSA-72706", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-RNO-72649", "R-GGA-72649", "R-DRE-72649", "R-SCE-72649", "R-DRE-72702", "R-DRE-72689", "R-SPO-156827", "R-DME-72702", "R-BTA-72649", "R-GGA-72695", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": ["R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-GGA-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-GGA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Homologous_superfamily"}, "IPR023195": {"description": "Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal", "go_ids": ["GO:0008939"], "go_terms": ["GO:0008939:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity:F"], "name": "Nict_dMeBzImd_PRibTrfase_N", "pathway_ids": ["PWY-7970", "PWY-7969", "PWY-5509", "PWY-7964", "PWY-7968", "PWY-7966", "PWY-7965", "PWY-7967", "PWY-6269"], "pathways": ["PWY-7970:t:benzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7969:t:5-hydroxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-5509:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I", "PWY-7964:t:adeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7968:t:5-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7966:t:5-methoxy-6-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7965:t:2-methyladeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7967:t:5-methoxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-6269:t:superpathway of adenosylcobalamin salvage from cobinamide II"], "type": "Homologous_superfamily"}, "IPR023196": {"description": "Phosducin, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Phosducin_N_dom_sf", "pathway_ids": ["R-RNO-6814122", "R-HSA-6814122", "R-BTA-6814122", "R-DME-6814122", "R-MMU-6814122"], "pathways": ["R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Homologous_superfamily"}, "IPR023197": {"description": "Bacteriophage T4, Gp59, helicase assembly protein domain superfamily", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp59_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023198": {"description": "Phosphoglycolate phosphatase-like, domain 2", "go_ids": [], "go_terms": [], "name": "PGP-like_dom2", "pathway_ids": ["R-SSC-9033241", "R-HSA-73614", "R-SPO-73614", "R-MMU-2142670", "R-MMU-73614", "R-MMU-9033241", "R-DME-73614", "R-RNO-9018682", "R-RNO-9033241", "R-SSC-9018682", "R-MMU-77289", "R-RNO-2142670", "R-SCE-73614", "R-HSA-9033241", "R-MMU-9018682", "R-HSA-9018682", "R-HSA-77289", "R-SSC-2142670", "R-HSA-2142670"], "pathways": ["R-SSC-9033241:r:Peroxisomal protein import", "R-HSA-73614:r:Pyrimidine salvage", "R-SPO-73614:r:Pyrimidine salvage", "R-MMU-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-MMU-73614:r:Pyrimidine salvage", "R-MMU-9033241:r:Peroxisomal protein import", "R-DME-73614:r:Pyrimidine salvage", "R-RNO-9018682:r:Biosynthesis of maresins", "R-RNO-9033241:r:Peroxisomal protein import", "R-SSC-9018682:r:Biosynthesis of maresins", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-SCE-73614:r:Pyrimidine salvage", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-9018682:r:Biosynthesis of maresins", "R-HSA-9018682:r:Biosynthesis of maresins", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SSC-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-HSA-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "type": "Homologous_superfamily"}, "IPR023199": {"description": "Copper chaperone GriE/MELC1 superfamily", "go_ids": [], "go_terms": [], "name": "GriE/MELC1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023200": {"description": "Ribosome modulation factor domain superfamily", "go_ids": [], "go_terms": [], "name": "RMF_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023201": {"description": "SecY domain superfamily", "go_ids": [], "go_terms": [], "name": "SecY_dom_sf", "pathway_ids": ["R-HSA-1799339", "R-HSA-1236974", "R-HSA-9760173", "R-HSA-1222387"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Homologous_superfamily"}, "IPR023202": {"description": "YejL-like superfamily", "go_ids": [], "go_terms": [], "name": "YejL_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023203": {"description": "TTHA0068-like superfamily", "go_ids": [], "go_terms": [], "name": "TTHA0068_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023204": {"description": "SP1917 domain superfamily", "go_ids": [], "go_terms": [], "name": "SP1917_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023205": {"description": "Thiol:disulphide interchange protein DsbA/DsbL", "go_ids": [], "go_terms": [], "name": "DsbA/DsbL", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR023206": {"description": "Bifunctional cytochrome P450/NADPH--cytochrome P450 reductase", "go_ids": ["GO:0003958", "GO:0070330"], "go_terms": ["GO:0003958:NADPH-hemoprotein reductase activity:F", "GO:0070330:aromatase activity:F"], "name": "Bifunctional_P450_P450_red", "pathway_ids": ["PWY-7466", "PWY-5665", "PWY-6992", "PWY-5451", "PWY-6398"], "pathways": ["PWY-7466:t:acetone degradation III (to propane-1,2-diol)", "PWY-5665:t:vanillin biosynthesis I", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-5451:t:acetone degradation I (to methylglyoxal)", "PWY-6398:t:melatonin degradation I"], "type": "Family"}, "IPR023208": {"description": "NADPH-cytochrome P450 reductase", "go_ids": ["GO:0003958"], "go_terms": ["GO:0003958:NADPH-hemoprotein reductase activity:F"], "name": "P450R", "pathway_ids": ["R-SCE-1222556", "R-SPO-392154", "R-DDI-1474151", "R-DDI-9009391", "R-SPO-1474151", "R-SCE-9009391", "R-SPO-5218920", "R-DDI-5578775", "R-SCE-1474151", "R-SCE-392154", "R-HSA-211897", "R-SCE-5578775", "R-DDI-203615", "R-SPO-203615", "R-SPO-9033241", "R-SPO-9009391", "R-DDI-9856530", "R-DDI-203754", "R-DDI-5218920", "R-SCE-9033241", "R-SCE-203615", "R-SPO-1222556", "R-DDI-1222556", "R-SPO-9856530", "R-SPO-5578775", "R-DDI-9033241", "R-SCE-9856530", "R-SCE-5218920", "R-DDI-392154"], "pathways": ["R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SPO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5578775:r:Ion homeostasis", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SCE-392154:r:Nitric oxide stimulates guanylate cyclase", "R-HSA-211897:r:Cytochrome P450 - arranged by substrate type", "R-SCE-5578775:r:Ion homeostasis", "R-DDI-203615:r:eNOS activation", "R-SPO-203615:r:eNOS activation", "R-SPO-9033241:r:Peroxisomal protein import", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-203754:r:NOSIP mediated eNOS trafficking", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-9033241:r:Peroxisomal protein import", "R-SCE-203615:r:eNOS activation", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-5578775:r:Ion homeostasis", "R-DDI-9033241:r:Peroxisomal protein import", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-392154:r:Nitric oxide stimulates guanylate cyclase"], "type": "Family"}, "IPR023209": {"description": "D-amino-acid oxidase", "go_ids": ["GO:0019478", "GO:0003884", "GO:0071949"], "go_terms": ["GO:0019478:D-amino acid catabolic process:P", "GO:0003884:D-amino-acid oxidase activity:F", "GO:0071949:FAD binding:F"], "name": "DAO", "pathway_ids": ["PWY-5283", "R-BTA-9033241", "R-BTA-389661", "R-SSC-9033241", "R-RNO-9033241", "R-SPO-9033241", "R-SPO-389661", "R-SSC-389661", "R-MMU-389661", "R-DDI-9033241", "R-DDI-389661", "R-RNO-389661", "R-CEL-389661", "R-MMU-9033241", "R-HSA-389661", "R-HSA-9033241"], "pathways": ["PWY-5283:t:L-lysine degradation V", "R-BTA-9033241:r:Peroxisomal protein import", "R-BTA-389661:r:Glyoxylate metabolism and glycine degradation", "R-SSC-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-SPO-389661:r:Glyoxylate metabolism and glycine degradation", "R-SSC-389661:r:Glyoxylate metabolism and glycine degradation", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-DDI-9033241:r:Peroxisomal protein import", "R-DDI-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-389661:r:Glyoxylate metabolism and glycine degradation", "R-CEL-389661:r:Glyoxylate metabolism and glycine degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR023210": {"description": "NADP-dependent oxidoreductase domain", "go_ids": [], "go_terms": [], "name": "NADP_OxRdtase_dom", "pathway_ids": ["R-HSA-6798695", "R-RNO-193807", "R-DME-70221", "R-RNO-5423646", "R-HSA-5423646", "R-BTA-6798695", "R-DME-2162123", "R-BTA-9757110", "R-MMU-156590", "R-BTA-193368", "R-DME-5652227", "R-SPO-193807", "R-SPO-5661270", "R-MMU-975634", "R-DDI-5661270", "R-SCE-5652227", "R-MMU-5423646", "R-BTA-2162123", "R-SCE-70221", "R-SPO-70221", "R-DDI-193368", "R-MMU-5652227", "R-DDI-193144", "R-RNO-193144", "R-SPO-5365859", "R-SPO-156590", "R-SCE-5365859", "R-HSA-196108", "R-HSA-70221", "R-SPO-5652227", "R-HSA-193775", "R-RNO-174403", "R-RNO-2162123", "R-RNO-5365859", "R-DDI-5365859", "R-DME-193144", "R-DDI-5652227", "R-SCE-5661270", "R-HSA-5365859", "R-BTA-975634", "R-HSA-193807", "R-SCE-193144", "R-RNO-193775", "R-RNO-156590", "R-MMU-5365859", "R-XTR-5661270", "R-BTA-5661270", "R-BTA-174403", "R-MMU-174403", "R-RNO-70221", "R-GGA-1296072", "R-DME-9757110", "R-RNO-193368", "R-HSA-70370", "R-HSA-5652227", "R-SPO-196108", "R-MMU-6798695", "R-HSA-5578999", "R-XTR-156590", "R-SCE-9757110", "R-DDI-2162123", "R-SPO-193368", "R-RNO-6798695", "R-HSA-9818027", "R-MMU-9757110", "R-DME-975634", "R-SPO-193144", "R-MMU-193807", "R-SPO-6798695", "R-BTA-5365859", "R-RNO-5661270", "R-BTA-193775", "R-BTA-1296072", "R-HSA-9757110", "R-MMU-70221", "R-MMU-193775", "R-HSA-193368", "R-DDI-193775", "R-DME-5365859", "R-DDI-196108", "R-HSA-156590", "R-BTA-193807", "R-DDI-9757110", "R-RNO-9757110", "R-HSA-5661270", "R-MMU-196108", "R-SPO-9757110", "R-SCE-193807", "R-MMU-5661270", "R-SCE-2162123", "R-DDI-193807", "R-DME-196108", "R-SPO-2162123", "R-SCE-193368", "R-RNO-975634", "R-HSA-174403", "R-DME-193807", "R-DME-193775", "R-MMU-1296072", "R-HSA-2162123", "R-DRE-5661270", "R-MMU-193368", "R-MMU-2162123", "R-SSC-70221", "R-RNO-5652227", "R-SCE-193775", "R-SCE-196108", "R-RNO-1296072", "R-RNO-196108", "R-SPO-193775", "R-DME-193368", "R-SCE-156590", "R-HSA-1296072", "R-HSA-193144", "R-MMU-193144", "R-DRE-156590", "R-HSA-975634", "R-DDI-70221", "R-BTA-156590", "R-DDI-156590"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DME-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-BTA-6798695:r:Neutrophil 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"R-MMU-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "type": "Homologous_superfamily"}, "IPR023319": {"description": "Tex-like protein, HTH domain superfamily", "go_ids": [], "go_terms": [], "name": "Tex-like_HTH_dom_sf", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Homologous_superfamily"}, "IPR023321": {"description": "PINIT domain", "go_ids": [], "go_terms": [], "name": "PINIT", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-HSA-4755510", "R-DRE-4085377", "R-DRE-3232142", "R-HSA-5693565", "R-RNO-3108214", "R-SCE-4085377", "R-MMU-69473", "R-MMU-5696395", "R-DRE-5693571", "R-MMU-4551638", "R-SPO-5696395", "R-HSA-5693607", "R-RNO-3232118", "R-MMU-3232118", "R-CEL-4551638", "R-HSA-4090294", "R-SPO-4085377", "R-SPO-3899300", "R-HSA-4551638", "R-RNO-4090294", "R-RNO-3899300", "R-CEL-4085377", "R-HSA-69473", "R-RNO-5696395", "R-CEL-3232118", "R-HSA-3232142", "R-CEL-4090294", "R-DRE-196791", "R-DRE-3232118", "R-CEL-5696395", "R-HSA-5696395", "R-MMU-196791", "R-HSA-3232118", "R-RNO-3232142", "R-DRE-5693565", "R-MMU-3108214", "R-MMU-5693571", "R-HSA-5617472", "R-SPO-3232118", "R-RNO-4615885", "R-DRE-5693607", "R-MMU-3232142", "R-HSA-3108214", "R-DRE-4615885", "R-CEL-3899300", "R-MMU-4615885", "R-MMU-5693565", "R-DRE-3108214", "R-MMU-4085377", "R-HSA-196791", "R-HSA-877312", "R-CEL-3232142", "R-CEL-3108214", "R-MMU-4090294", "R-HSA-4615885", "R-SCE-3232118", "R-MMU-877312", "R-MMU-5693607", "R-MMU-3899300", "R-DRE-4755510", "R-SPO-4551638", "R-HSA-4085377", "R-RNO-4755510", "R-DRE-3899300", "R-RNO-4551638", "R-HSA-5693571", "R-SCE-4551638", "R-DRE-4090294", "R-CEL-877312", "R-HSA-3899300", "R-MMU-4755510"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-DRE-4085377:r:SUMOylation of SUMOylation proteins", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-CEL-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CEL-4090294:r:SUMOylation of intracellular receptors", "R-DRE-196791:r:Vitamin D (calciferol) metabolism", "R-DRE-3232118:r:SUMOylation of transcription factors", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SPO-3232118:r:SUMOylation of transcription factors", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-877312:r:Regulation of IFNG signaling", "R-CEL-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-DRE-4755510:r:SUMOylation of immune response proteins", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-4755510:r:SUMOylation of immune response proteins", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SCE-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-4090294:r:SUMOylation of intracellular receptors", "R-CEL-877312:r:Regulation of IFNG signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-4755510:r:SUMOylation of immune response proteins"], "type": "Domain"}, "IPR023322": {"description": "Outer surface lipoprotein domain superfamily", "go_ids": [], "go_terms": [], "name": "OM_lipoprot_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023323": {"description": "Tex-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Tex-like_dom_sf", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Homologous_superfamily"}, "IPR023324": {"description": "BH2638-like superfamily", "go_ids": [], "go_terms": [], "name": "BH2638-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023330": {"description": "Rhabdovirus nucleocapsid, N-terminal", "go_ids": [], "go_terms": [], "name": "Rhabdovirus_ncapsid_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023331": {"description": "Rhabdovirus nucleocapsid, C-terminal", "go_ids": [], "go_terms": [], "name": "Rhabdovirus_ncapsid_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023333": {"description": "Proteasome B-type subunit", "go_ids": [], "go_terms": [], "name": "Proteasome_suB-type", "pathway_ids": ["R-HSA-174178", "R-SSC-9766229", "R-DRE-4641258", "R-SSC-5689603", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-SSC-8948751", "R-HSA-8951664", "R-HSA-9010553", "R-BTA-9755511", "R-HSA-75815", "R-CEL-8941858", "R-DRE-2467813", "R-MMU-8948751", "R-DME-8948751", "R-SSC-174184", "R-DRE-8941858", "R-SPO-5689880", "R-CFA-9907900", "R-MMU-5689880", "R-CEL-1234176", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-DME-5676590", "R-RNO-8854050", "R-DME-9912633", "R-HSA-450408", "R-DRE-69017", "R-RNO-450408", "R-SCE-5689880", "R-HSA-211733", "R-SSC-8939902", "R-DDI-6798695", "R-DME-4641257", "R-HSA-5607761", "R-DME-432524", "R-DDI-174084", "R-DRE-8948751", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DRE-9766229", "R-SPO-9912633", "R-HSA-909733", "R-DDI-4641258", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-SSC-8939236", "R-BTA-4641257", "R-CEL-8948751", "R-DRE-5610785", "R-SSC-9932298", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-RNO-69481", "R-DDI-187577", "R-RNO-9932298", "R-RNO-5632684", "R-SSC-6798695", "R-MMU-187577", "R-RNO-1234176", "R-BTA-1236978", "R-SSC-450408", "R-DDI-382556", "R-DRE-195253", "R-DME-202424", "R-DME-187577", "R-DRE-5610780", "R-RNO-174178", "R-DRE-4641257", "R-HSA-9824272", "R-MMU-174178", "R-BTA-5676590", "R-BTA-4608870", "R-MMU-349425", "R-DRE-983168", "R-BTA-2871837", "R-HSA-9907900", "R-CEL-8854050", "R-BTA-174154", "R-DME-350562", "R-DME-174084", "R-DDI-69601", "R-SCE-1236974", "R-DME-9929491", "R-HSA-9762114", "R-SSC-5358346", "R-DDI-5689880", "R-SSC-8941858", "R-HSA-195253", "R-DRE-174178", "R-DRE-5358346", "R-BTA-187577", "R-CEL-9755511", "R-RNO-9755511", "R-DME-8939236", "R-SSC-5607764", "R-DME-174184", "R-RNO-174113", "R-SSC-187577", "R-BTA-9929356", "R-MMU-5676590", "R-MMU-174184", "R-RNO-187577", "R-RNO-68867", "R-RNO-350562", "R-DME-9932298", "R-RNO-9762114", "R-BTA-9954709", "R-DME-9020702", "R-RNO-69017", "R-CEL-9762114", "R-DME-5689880", "R-SPO-350562", "R-HSA-5358346", "R-CEL-8951664", "R-HSA-6798695", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-BTA-5610785", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-RNO-9912633", "R-DDI-1236974", "R-DDI-1236978", "R-SSC-4641257", "R-SSC-5610780", "R-MMU-8951664", "R-DDI-8951664", "R-DME-8939902", "R-RNO-174154", "R-CEL-382556", "R-CEL-5689603", "R-DRE-6798695", "R-MMU-9929356", "R-HSA-9912633", "R-DME-4608870", "R-SCE-5668541", "R-DME-1236974", "R-RNO-9929356", "R-BTA-9912633", "R-HSA-69481", "R-DME-9762114", "R-BTA-174084", "R-SSC-1169091", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DRE-9907900", "R-SSC-1234176", "R-HSA-4641258", "R-SPO-5689603", "R-SSC-68949", "R-RNO-8939236", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-BTA-4641258", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", 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"R-CEL-5689880", "R-MMU-8939902", "R-DRE-9932298", "R-DME-174178", "R-RNO-195253", "R-HSA-8939236", "R-DRE-8854050", "R-BTA-983168", "R-DDI-8854050", "R-MMU-5607764", "R-DRE-5632684", "R-DME-8951664", "R-DRE-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577", "R-HSA-5676590", "R-DRE-9954709", "R-DRE-1236978", "R-DDI-5632684", "R-BTA-9929491", "R-CEL-9912633", "R-SSC-68867", "R-HSA-4641257", "R-RNO-202424", "R-MMU-9929491", "R-BTA-9932298", "R-HSA-174113", "R-SSC-69481", "R-BTA-9762114", "R-RNO-5607761", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-CEL-4641258", "R-BTA-450408", "R-DDI-5658442", "R-HSA-8941858", "R-HSA-9755511", "R-RNO-9931269", "R-DRE-1234176", "R-SSC-69601", "R-CEL-9929491", "R-DME-9755511", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-DRE-5658442", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-DME-5610785", "R-HSA-5689603", "R-RNO-983168", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DME-1169091", "R-DRE-9912633", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-BTA-8941858", "R-DME-5610780", "R-DME-4641258", "R-SSC-174178", "R-SSC-8951664", "R-HSA-174184", "R-SPO-1236974", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-SSC-174084", "R-DRE-9929491", "R-CEL-1236974", "R-BTA-2467813", "R-MMU-5610785", "R-DRE-69481", "R-DRE-8852276", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-SSC-1236978", "R-SSC-5689880", "R-MMU-8854050", "R-MMU-5689603", "R-SSC-5658442", "R-MMU-9912633", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-DRE-5687128", "R-DRE-5689880", "R-SSC-5668541", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DRE-174084", "R-DRE-450408", "R-SSC-9954709", "R-SSC-8852276", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-HSA-5687128", "R-DME-5632684", "R-DME-432395", "R-RNO-5658442", "R-MMU-1236974", "R-MMU-983168", "R-RNO-5610785", "R-SSC-4608870", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-DRE-4641258:r:Degradation of DVL", "R-SSC-5689603:r:UCH proteinases", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-SSC-8948751:r:Regulation of PTEN stability and activity", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-CFA-9907900:r:Proteasome assembly", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-SSC-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-432524:r:Degradation of PER", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-SPO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-SSC-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-DRE-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-69481:r:G2/M Checkpoints", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5632684:r:Hedgehog 'on' state", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SSC-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DRE-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-4641257:r:Degradation of AXIN", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9907900:r:Proteasome assembly", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-1236974:r:ER-Phagosome pathway", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SSC-5358346:r:Hedgehog ligand biogenesis", "R-DDI-5689880:r:Ub-specific processing proteases", "R-SSC-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-1236974:r:ER-Phagosome pathway", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SSC-4641257:r:Degradation of AXIN", "R-SSC-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CEL-5689603:r:UCH proteinases", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-1236974:r:ER-Phagosome pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-DRE-9907900:r:Proteasome assembly", "R-SSC-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-4641258:r:Degradation of DVL", "R-SPO-5689603:r:UCH proteinases", "R-SSC-68949:r:Orc1 removal from chromatin", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-4641258:r:Degradation of DVL", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-SSC-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-1236974:r:ER-Phagosome pathway", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-DRE-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-9912633:r:Antigen processing: 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"R-HSA-6798695", "R-HSA-9638771", "R-DDI-6798695", "R-SSC-6798695", "R-RNO-6803157", "R-BTA-6803157", "R-DME-6798695", "R-HSA-977225", "R-BTA-6798695", "R-HSA-5653890", "R-GGA-6798695", "R-DME-6803157", "R-SSC-5653890", "R-GGA-6803157", "R-MMU-5653890", "R-CFA-6803157", "R-SSC-6803157", "R-HSA-6803157", "R-MMU-6798695", "R-MMU-6803157", "R-CFA-6798695", "R-DDI-6803157", "R-GGA-5653890", "R-HSA-9927426"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9638771:r:Action of antimicrobials", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-6803157:r:Antimicrobial peptides", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-5653890:r:Lactose synthesis", "R-GGA-6798695:r:Neutrophil degranulation", "R-DME-6803157:r:Antimicrobial peptides", "R-SSC-5653890:r:Lactose synthesis", "R-GGA-6803157:r:Antimicrobial peptides", "R-MMU-5653890:r:Lactose synthesis", "R-CFA-6803157:r:Antimicrobial peptides", "R-SSC-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-6803157:r:Antimicrobial peptides", "R-CFA-6798695:r:Neutrophil degranulation", "R-DDI-6803157:r:Antimicrobial peptides", "R-GGA-5653890:r:Lactose synthesis", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Homologous_superfamily"}, "IPR023347": {"description": "Lysozyme domain superfamily", "go_ids": ["GO:0003796"], "go_terms": ["GO:0003796:lysozyme activity:F"], "name": "Lysozyme_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023349": {"description": "Ammonia monooxygenase/particulate methane monooxygenase, subunit C domain superfamily", "go_ids": [], "go_terms": [], "name": "NH3_CH4_mOase_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023351": {"description": "YppE-like superfamily", "go_ids": [], "go_terms": [], "name": "YppE-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023352": {"description": "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily", "go_ids": [], "go_terms": [], "name": "MAPEG-like_dom_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-2142700", "R-HSA-2142691", "R-SSC-6798695", "R-HSA-9026766", "R-BTA-9026762", "R-RNO-5423646", "R-RNO-2142700", "R-HSA-5423646", "R-DDI-156590", "R-RNO-2142688", "R-HSA-156590", "R-SSC-5423646", "R-MMU-156590", "R-DDI-2142688", "R-MMU-5423646", "R-BTA-5423646", "R-BTA-2162123", "R-MMU-2142688", "R-RNO-9026766", "R-DDI-2142691", "R-MMU-2142700", "R-DDI-2142700", "R-BTA-2142700", "R-RNO-9026762", "R-BTA-9026766", "R-HSA-2162123", "R-DDI-9026762", "R-RNO-2162123", "R-MMU-2162123", "R-HSA-2142688", "R-DDI-9026766", "R-CFA-2162123", "R-MMU-9026762", "R-RNO-156590", "R-RNO-2142691", "R-SSC-156590", "R-MMU-9026766", "R-HSA-9026762", "R-MMU-2142691", "R-MMU-6798695", "R-DDI-5423646", "R-BTA-2142691", "R-RNO-6798695", "R-BTA-156590", "R-BTA-2142688"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-9026766:r:Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)", "R-BTA-9026762:r:Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-RNO-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-DDI-156590:r:Glutathione conjugation", "R-RNO-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-HSA-156590:r:Glutathione conjugation", "R-SSC-5423646:r:Aflatoxin activation and detoxification", "R-MMU-156590:r:Glutathione conjugation", "R-DDI-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-BTA-5423646:r:Aflatoxin activation and detoxification", "R-BTA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-RNO-9026766:r:Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)", "R-DDI-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-2142700:r:Biosynthesis of Lipoxins (LX)", "R-DDI-2142700:r:Biosynthesis of Lipoxins (LX)", "R-BTA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-RNO-9026762:r:Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "R-BTA-9026766:r:Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-DDI-9026762:r:Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "R-RNO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-DDI-9026766:r:Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)", "R-CFA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-9026762:r:Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "R-RNO-156590:r:Glutathione conjugation", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SSC-156590:r:Glutathione conjugation", "R-MMU-9026766:r:Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)", "R-HSA-9026762:r:Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-5423646:r:Aflatoxin activation and detoxification", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-156590:r:Glutathione conjugation", "R-BTA-2142688:r:Synthesis of 5-eicosatetraenoic acids"], "type": "Homologous_superfamily"}, "IPR023353": {"description": "LemA-like domain superfamily", "go_ids": [], "go_terms": [], "name": "LemA-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023355": {"description": "Myotoxin/Anemone neurotoxin domain superfamily", "go_ids": [], "go_terms": [], "name": "Myo_ane_neurotoxin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023356": {"description": "Leucyl-tRNA synthetase, domain 3", "go_ids": [], "go_terms": [], "name": "Leu-tRNA-synth_dom3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023358": {"description": "Peptidase M18, domain 2", "go_ids": ["GO:0004177"], "go_terms": ["GO:0004177:aminopeptidase activity:F"], "name": "Peptidase_M18_dom2", "pathway_ids": ["PWY-7694", "PWY-6423", "PWY-7954"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-6423:t:hemoglobin degradation", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis"], "type": "Homologous_superfamily"}, "IPR023359": {"description": "Dihydroorotate dehydrogenase A, chain A, domain 2", "go_ids": [], "go_terms": [], "name": "Dihydro_DH_chainA_dom2", "pathway_ids": ["PWY-7790"], "pathways": ["PWY-7790:t:UMP biosynthesis II"], "type": "Homologous_superfamily"}, "IPR023361": {"description": "DUF1285, beta-roll domain superfamily", "go_ids": [], "go_terms": [], "name": "DUF1285_beta_roll_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023362": {"description": "PH-BEACH domain", "go_ids": [], "go_terms": [], "name": "PH-BEACH_dom", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-DRE-6798695", "R-HSA-5626978", "R-HSA-2122947", "R-MMU-6798695", "R-MMU-5626978", "R-HSA-112314", "R-HSA-9609736", "R-HSA-163615"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-163615:r:PKA activation"], "type": "Domain"}, "IPR023364": {"description": "Trans-sialidase, domain 3", "go_ids": [], "go_terms": [], "name": "Trans_sialidase_dom3", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023365": {"description": "Sortase domain superfamily", "go_ids": [], "go_terms": [], "name": "Sortase_dom-sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023366": {"description": "ATP synthase subunit alpha, N-terminal domain-like superfamily", "go_ids": [], "go_terms": [], "name": "ATP_synth_asu-like_sf", "pathway_ids": ["PWY-7980", "R-MMU-1222556", "R-CEL-1222556", "R-MMU-9837999", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-CEL-163210", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-HSA-9639288", "R-DME-8949613", "R-PFA-917977", "R-HSA-1222556", "R-HSA-1268020", "R-SPO-917977", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-HSA-9837999", "R-RNO-163210", "R-MMU-8949613", "R-SSC-163210", "R-DDI-9837999", "R-SCE-1222556", "R-SCE-917977", "R-MMU-77387", "R-BTA-1222556", "R-DDI-9639288", "R-SCE-77387", "R-CEL-9837999", "R-SSC-8949613", "R-BTA-983712", "R-DME-917977", "R-DME-9837999", "R-MMU-163210", "R-DME-77387", "R-DME-163210", "R-CEL-8949613", "R-RNO-9837999", "R-HSA-8949613", "R-HSA-163210", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-PFA-1222556", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-9837999", "R-SPO-77387", "R-SCE-9837999", "R-CEL-917977", "R-SSC-9837999", "R-HSA-917977", "R-MMU-983712", "R-RNO-8949613", "R-DDI-983712", "R-BTA-77387", "R-DDI-917977", "R-PFA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["PWY-7980:t:ATP biosynthesis", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DME-8949613:r:Cristae formation", "R-PFA-917977:r:Transferrin endocytosis and recycling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-8949613:r:Cristae formation", "R-SSC-163210:r:Formation of ATP by chemiosmotic coupling", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-MMU-77387:r:Insulin receptor recycling", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-SCE-77387:r:Insulin receptor recycling", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SSC-8949613:r:Cristae formation", "R-BTA-983712:r:Ion channel transport", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-77387:r:Insulin receptor recycling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-PFA-1222556:r:ROS and RNS production in phagocytes", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SPO-77387:r:Insulin receptor recycling", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-RNO-8949613:r:Cristae formation", "R-DDI-983712:r:Ion channel transport", "R-BTA-77387:r:Insulin receptor recycling", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-PFA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR023367": {"description": "Peptidase M42, domain 2", "go_ids": [], "go_terms": [], "name": "Peptidase_M42_dom2", "pathway_ids": ["PWY-7694", "PWY-6423", "PWY-7954"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-6423:t:hemoglobin degradation", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis"], "type": "Homologous_superfamily"}, "IPR023370": {"description": "TrmO-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TrmO-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023372": {"description": "Restriction endonuclease, type II, EcoRII, N-terminal", "go_ids": [], "go_terms": [], "name": "Rest_endonuc_II_EcoRII_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023373": {"description": "YmcC-like superfamily", "go_ids": [], "go_terms": [], "name": "YmcC_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023374": {"description": "AttH-like domain superfamily", "go_ids": [], "go_terms": [], "name": "AttH-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023375": {"description": "Acetoacetate decarboxylase domain superfamily", "go_ids": [], "go_terms": [], "name": "ADC_dom_sf", "pathway_ids": ["PWY-6876", "PWY-6588"], "pathways": ["PWY-6876:t:isopropanol biosynthesis (engineered)", "PWY-6588:t:pyruvate fermentation to acetone"], "type": "Homologous_superfamily"}, "IPR023376": {"description": "YqcC-like domain", "go_ids": [], "go_terms": [], "name": "YqcC-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023378": {"description": "YheA/YmcA-like domain superfamily", "go_ids": [], "go_terms": [], "name": "YheA/YmcA-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023379": {"description": "BART domain", "go_ids": [], "go_terms": [], "name": "BART_dom", "pathway_ids": ["R-XTR-83936", "R-HSA-83936", "R-BTA-83936", "R-RNO-83936", "R-MMU-83936", "R-DRE-83936"], "pathways": ["R-XTR-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-BTA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-DRE-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "type": "Domain"}, "IPR023380": {"description": "DsbB-like superfamily", "go_ids": [], "go_terms": [], "name": "DsbB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023381": {"description": "YP001051499.1-like domain superfamily", "go_ids": [], "go_terms": [], "name": "YP001051499.1-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023382": {"description": "tRNA-specific 2-thiouridylase MnmA-like, central domain superfamily", "go_ids": ["GO:0016783"], "go_terms": ["GO:0016783:sulfurtransferase activity:F"], "name": "MnmA-like_central_sf", "pathway_ids": ["PWY-7892", "PWY-7887", "R-HSA-6787450"], "pathways": ["PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Homologous_superfamily"}, "IPR023383": {"description": "Ferredoxin, chloroplast transit peptide", "go_ids": [], "go_terms": [], "name": "Ferredoxin_transit_pept", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023385": {"description": "YopX-like, C-terminal", "go_ids": [], "go_terms": [], "name": "YopX-like_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023387": {"description": "DUF1653-like domain", "go_ids": [], "go_terms": [], "name": "DUF1653-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023388": {"description": "Bacteriocin class IIa domain superfamily", "go_ids": [], "go_terms": [], "name": "Bacteriocin_IIa_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023389": {"description": "DOPA-like superfamily", "go_ids": [], "go_terms": [], "name": "DOPA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023390": {"description": "Bacteriophage M13, G8P, capsid domain superfamily", "go_ids": [], "go_terms": [], "name": "Phage_M13_G8P_capsid_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023391": {"description": "Protein translocase SecE domain superfamily", "go_ids": [], "go_terms": [], "name": "Prot_translocase_SecE_dom_sf", "pathway_ids": ["R-HSA-1799339", "R-CEL-9609523", "R-SPO-9609523", "R-CFA-9609523", "R-DDI-9609523", "R-DME-9609523", "R-HSA-1236974", "R-MMU-9609523", "R-SCE-9609523", "R-HSA-9609523", "R-BTA-9609523"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CFA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Homologous_superfamily"}, "IPR023392": {"description": "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily", "go_ids": [], "go_terms": [], "name": "Tom20_dom_sf", "pathway_ids": ["R-MMU-5205685", "R-DRE-5689880", "R-MMU-5689880", "R-RNO-5205685", "R-HSA-1268020", "R-BTA-5689880", "R-BTA-5205685", "R-HSA-5689880", "R-XTR-5205685", "R-HSA-5205685", "R-CEL-5205685", "R-DRE-5205685", "R-SCE-5205685", "R-RNO-5689880"], "pathways": ["R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5689880:r:Ub-specific processing proteases", "R-XTR-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DRE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SCE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-5689880:r:Ub-specific processing proteases"], "type": "Homologous_superfamily"}, "IPR023393": {"description": "START-like domain superfamily", "go_ids": [], "go_terms": [], "name": "START-like_dom_sf", "pathway_ids": ["R-RNO-9013026", "R-MMU-9837999", "R-MMU-9013106", "R-RNO-1483191", "R-DRE-611105", "R-MMU-8980692", "R-MMU-1483191", "R-DRE-9864848", "R-RNO-8980692", "R-RNO-9013149", "R-MMU-9013148", "R-HSA-9013106", "R-MMU-2142789", "R-DME-1483226", "R-DDI-8951664", "R-MMU-196108", "R-DME-9864848", "R-RNO-77289", "R-BTA-9837999", "R-HSA-9013148", "R-BTA-1483196", "R-MMU-611105", "R-HSA-2142789", "R-HSA-9837999", "R-MMU-9864848", "R-RNO-9013406", "R-HSA-1483196", "R-DRE-1660661", "R-RNO-9013106", "R-HSA-77289", "R-MMU-1483196", "R-DDI-1483196", "R-HSA-1483226", "R-HSA-196108", "R-DRE-196108", "R-DDI-1483226", "R-MMU-1483226", "R-BTA-77289", "R-HSA-8950505", "R-RNO-9013148", "R-RNO-9837999", "R-HSA-1660661", "R-BTA-159418", "R-RNO-196108", "R-DME-611105", "R-BTA-1660661", "R-DRE-9837999", "R-DDI-983168", "R-RNO-611105", "R-HSA-9864848", "R-HSA-611105", "R-HSA-8980692", "R-HSA-9013149", "R-HSA-1483191", "R-MMU-9013406", "R-BTA-196108", "R-MMU-9013026", "R-MMU-77289", "R-RNO-1483196", "R-HSA-418890", "R-HSA-9013026", "R-HSA-159418", "R-HSA-9013406", "R-BTA-1483191", "R-MMU-9013149", "R-RNO-1483226", "R-MMU-159418"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-1483191:r:Synthesis of PC", "R-DRE-611105:r:Respiratory electron transport", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-1483191:r:Synthesis of PC", "R-DRE-9864848:r:Complex IV assembly", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DME-1483226:r:Synthesis of PI", "R-DDI-8951664:r:Neddylation", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-DME-9864848:r:Complex IV assembly", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-1483196:r:PI and PC transport between ER and Golgi membranes", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9864848:r:Complex IV assembly", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-1483196:r:PI and PC transport between ER and Golgi membranes", "R-DRE-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-1483196:r:PI and PC transport between ER and Golgi membranes", "R-DDI-1483196:r:PI and PC transport between ER and Golgi membranes", "R-HSA-1483226:r:Synthesis of PI", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-DRE-196108:r:Pregnenolone biosynthesis", "R-DDI-1483226:r:Synthesis of PI", "R-MMU-1483226:r:Synthesis of PI", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-BTA-159418:r:Recycling of bile acids and salts", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1483191:r:Synthesis of PC", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-BTA-196108:r:Pregnenolone biosynthesis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-1483196:r:PI and PC transport between ER and Golgi membranes", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-BTA-1483191:r:Synthesis of PC", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-1483226:r:Synthesis of PI", "R-MMU-159418:r:Recycling of bile acids and salts"], "type": "Homologous_superfamily"}, "IPR023394": {"description": "Sec7, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Sec7_C_sf", "pathway_ids": ["R-SPO-6807878", "R-SPO-199992", "R-CEL-199992", "R-HSA-6811438", "R-MMU-6811438", "R-SCE-6807878", "R-SCE-6811434", "R-MMU-5620916", "R-HSA-390471", "R-DDI-9907900", "R-RNO-6811438", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-HSA-199992", "R-HSA-5620916", "R-HSA-6811434", "R-SPO-6811438", "R-SPO-5620916", "R-HSA-9918476", "R-SPO-6811434", "R-SCE-6811438", "R-MMU-199992", "R-CEL-5620916", "R-CEL-6811438", "R-SCE-5620916", "R-HSA-9918481", "R-CEL-6811434", "R-SCE-199992", "R-HSA-9768919", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-SPO-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811438:r:Intra-Golgi traffic", "R-SPO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811438:r:Intra-Golgi traffic", "R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-6811438:r:Intra-Golgi traffic", "R-SCE-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR023395": {"description": "Mitochondrial carrier protein domain superfamily", "go_ids": [], "go_terms": [], "name": "MCP_dom_sf", "pathway_ids": ["R-HSA-1362409", "R-RNO-83936", "R-HSA-389599", "R-HSA-9856872", "R-HSA-167826", "R-SSC-1268020", "R-HSA-442660", "R-DDI-9603798", "R-RNO-166187", "R-SCE-1614517", "R-CEL-1614517", "R-DDI-71064", "R-BTA-428643", "R-DDI-70635", "R-MMU-199220", "R-CEL-200425", "R-MMU-389599", "R-DRE-549127", "R-DDI-196819", "R-MMU-166187", "R-SCE-166187", "R-HSA-9844594", "R-HSA-1268020", "R-MMU-196757", "R-BTA-9837999", "R-HSA-71064", "R-DME-9856872", "R-SPO-199220", "R-DDI-199220", "R-SSC-428643", "R-SCE-83936", "R-MMU-9603798", "R-SCE-1268020", "R-SCE-442660", "R-SCE-200425", "R-RNO-167826", "R-BTA-9856872", "R-SCE-8963693", "R-SPO-70635", "R-DDI-389599", "R-MMU-200425", "R-SCE-199220", "R-DDI-83936", "R-RNO-8963693", "R-HSA-8963693", "R-HSA-196807", "R-HSA-70895", "R-HSA-9956508", "R-SPO-1268020", "R-HSA-196819", "R-RNO-196807", "R-CEL-9856872", "R-SCE-9856872", "R-HSA-196757", "R-RNO-196819", "R-MMU-70635", "R-RNO-1614517", "R-BTA-442660", "R-DDI-428643", "R-SSC-9856872", "R-HSA-166187", "R-MMU-8963693", "R-DDI-8963693", "R-HSA-549127", "R-BTA-83936", "R-HSA-168277", "R-BTA-196819", "R-DDI-196757", "R-HSA-180897", "R-DME-1268020", "R-DME-167826", "R-DDI-166187", "R-MMU-196807", "R-MMU-9837999", "R-MMU-549127", "R-DME-200425", "R-DME-549127", "R-SSC-83936", "R-HSA-1614517", "R-BTA-549127", "R-HSA-199220", "R-SCE-196819", "R-MMU-83936", "R-RNO-199220", "R-HSA-428643", "R-SCE-428643", "R-BTA-352230", "R-DME-83936", "R-XTR-549127", "R-RNO-442660", "R-DDI-9856872", "R-RNO-352230", "R-MMU-352230", "R-SPO-196819", "R-HSA-352230", "R-DME-8963693", "R-MMU-442660", "R-MMU-167826", "R-BTA-1268020", "R-DRE-428643", "R-RNO-200425", "R-DRE-167826", "R-HSA-9837999", "R-RNO-428643", "R-XTR-199220", "R-BTA-71064", "R-SSC-167826", "R-HSA-9603798", "R-CEL-8963693", "R-MMU-1614517", "R-DRE-199220", "R-MMU-428643", "R-SPO-352230", "R-DDI-9837999", "R-CEL-428643", "R-MMU-71064", "R-DDI-1268020", "R-HSA-83936", "R-SPO-549127", "R-DME-9837999", "R-DDI-1614517", "R-HSA-70635", "R-RNO-9837999", "R-BTA-166187", "R-RNO-70635", "R-RNO-71064", "R-BTA-167826", "R-MMU-196819", "R-DDI-442660", "R-HSA-200425", "R-SPO-9837999", "R-SPO-166187", "R-SCE-9837999", "R-MMU-9856872", "R-SSC-9837999", "R-RNO-9856872", "R-SPO-428643", "R-SCE-196757", "R-SCE-549127", "R-SPO-196757", "R-SCE-70635", "R-SPO-83936"], "pathways": ["R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-HSA-9856872:r:Malate-aspartate shuttle", "R-HSA-167826:r:The fatty acid cycling model", "R-SSC-1268020:r:Mitochondrial protein import", "R-HSA-442660:r:SLC-mediated transport of neurotransmitters", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-166187:r:Mitochondrial Uncoupling", "R-SCE-1614517:r:Sulfide oxidation to sulfate", "R-CEL-1614517:r:Sulfide oxidation to sulfate", "R-DDI-71064:r:Lysine catabolism", "R-BTA-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-DDI-70635:r:Urea cycle", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-CEL-200425:r:Carnitine shuttle", "R-MMU-389599:r:Alpha-oxidation of phytanate", "R-DRE-549127:r:SLC-mediated transport of organic cations", "R-DDI-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-166187:r:Mitochondrial Uncoupling", "R-SCE-166187:r:Mitochondrial Uncoupling", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-196757:r:Metabolism of folate and pterines", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-71064:r:Lysine catabolism", "R-DME-9856872:r:Malate-aspartate shuttle", "R-SPO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SSC-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SCE-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-1268020:r:Mitochondrial protein import", "R-SCE-442660:r:SLC-mediated transport of neurotransmitters", "R-SCE-200425:r:Carnitine shuttle", "R-RNO-167826:r:The fatty acid cycling model", "R-BTA-9856872:r:Malate-aspartate shuttle", "R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-SPO-70635:r:Urea cycle", "R-DDI-389599:r:Alpha-oxidation of phytanate", "R-MMU-200425:r:Carnitine shuttle", "R-SCE-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DDI-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9956508:r:SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome", "R-SPO-1268020:r:Mitochondrial protein import", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-SCE-9856872:r:Malate-aspartate shuttle", "R-HSA-196757:r:Metabolism of folate and pterines", "R-RNO-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-70635:r:Urea cycle", "R-RNO-1614517:r:Sulfide oxidation to sulfate", "R-BTA-442660:r:SLC-mediated transport of neurotransmitters", "R-DDI-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SSC-9856872:r:Malate-aspartate shuttle", "R-HSA-166187:r:Mitochondrial Uncoupling", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-DDI-8963693:r:Aspartate and asparagine metabolism", "R-HSA-549127:r:SLC-mediated transport of organic cations", "R-BTA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-168277:r:Influenza Virus Induced Apoptosis", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism", "R-DDI-196757:r:Metabolism of folate and pterines", "R-HSA-180897:r:Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "R-DME-1268020:r:Mitochondrial protein import", "R-DME-167826:r:The fatty acid cycling model", "R-DDI-166187:r:Mitochondrial Uncoupling", "R-MMU-196807:r:Nicotinate metabolism", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-DME-200425:r:Carnitine shuttle", "R-DME-549127:r:SLC-mediated transport of organic cations", "R-SSC-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-1614517:r:Sulfide oxidation to sulfate", "R-BTA-549127:r:SLC-mediated transport of organic cations", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-SCE-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SCE-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-BTA-352230:r:Amino acid transport across the plasma membrane", "R-DME-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-XTR-549127:r:SLC-mediated transport of organic cations", "R-RNO-442660:r:SLC-mediated transport of neurotransmitters", "R-DDI-9856872:r:Malate-aspartate shuttle", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-MMU-352230:r:Amino acid transport across the plasma membrane", "R-SPO-196819:r:Vitamin B1 (thiamin) metabolism", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-DME-8963693:r:Aspartate and asparagine metabolism", "R-MMU-442660:r:SLC-mediated transport of neurotransmitters", "R-MMU-167826:r:The fatty acid cycling model", "R-BTA-1268020:r:Mitochondrial protein import", "R-DRE-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-RNO-200425:r:Carnitine shuttle", "R-DRE-167826:r:The fatty acid cycling model", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-XTR-199220:r:Vitamin B5 (pantothenate) metabolism", "R-BTA-71064:r:Lysine catabolism", "R-SSC-167826:r:The fatty acid cycling model", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-DRE-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SPO-352230:r:Amino acid transport across the plasma membrane", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-CEL-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-MMU-71064:r:Lysine catabolism", "R-DDI-1268020:r:Mitochondrial protein import", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-SPO-549127:r:SLC-mediated transport of organic cations", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DDI-1614517:r:Sulfide oxidation to sulfate", "R-HSA-70635:r:Urea cycle", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-166187:r:Mitochondrial Uncoupling", "R-RNO-70635:r:Urea cycle", "R-RNO-71064:r:Lysine catabolism", "R-BTA-167826:r:The fatty acid cycling model", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism", "R-DDI-442660:r:SLC-mediated transport of neurotransmitters", "R-HSA-200425:r:Carnitine shuttle", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SPO-166187:r:Mitochondrial Uncoupling", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-SPO-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SCE-549127:r:SLC-mediated transport of organic cations", "R-SPO-196757:r:Metabolism of folate and pterines", "R-SCE-70635:r:Urea cycle", "R-SPO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "type": "Homologous_superfamily"}, "IPR023397": {"description": "S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain superfamily", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "SAM-dep_MeTrfase_MraW_recog", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023398": {"description": "Translation Initiation factor eIF- 4e-like", "go_ids": [], "go_terms": [], "name": "TIF_eIF4e-like", "pathway_ids": ["R-CEL-159231", "R-CEL-159227", "R-HSA-9918487", "R-MMU-72706", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-CEL-159230", "R-DRE-166208", "R-DDI-72662", "R-SCE-72702", "R-DME-72662", "R-RNO-156827", "R-SPO-72706", "R-HSA-429947", "R-SCE-72662", "R-HSA-72706", "R-DME-159227", "R-CEL-72662", "R-HSA-72702", "R-RNO-429947", "R-CEL-156827", "R-HSA-159231", "R-RNO-72649", "R-MMU-159227", "R-DRE-72662", "R-DRE-159227", "R-DME-110523", "R-CEL-72649", "R-HSA-9820841", "R-SPO-156827", "R-DME-72702", "R-RNO-72662", "R-SPO-429947", "R-DDI-72702", "R-HSA-72662", "R-SCE-429947", "R-SPO-72702", "R-DME-156827", "R-SPO-159227", "R-DME-429947", "R-SPO-159231", "R-DRE-159231", "R-CEL-72702", "R-DME-159231", "R-DME-72649", "R-HSA-156827", "R-HSA-1169408", "R-MMU-72649", "R-RNO-166208", "R-HSA-159227", "R-HSA-9820865", "R-HSA-166208", "R-MMU-429947", "R-MMU-72662", "R-DME-166208", "R-MMU-159231", "R-DDI-1169408", "R-DRE-156827", "R-SPO-72662", "R-SCE-156827", "R-MMU-72702", "R-SPO-72649", "R-DDI-166208", "R-RNO-72702", "R-MMU-1169408", "R-RNO-159227", "R-HSA-72649", "R-MMU-156827", "R-DME-159230", "R-DRE-72649", "R-SCE-72649", "R-CEL-1169408", "R-DRE-72702", "R-RNO-159231", "R-MMU-166208", "R-DDI-156827"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DRE-166208:r:mTORC1-mediated signalling", "R-DDI-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-429947:r:Deadenylation of mRNA", "R-SCE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-429947:r:Deadenylation of mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-72649:r:Translation initiation complex formation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-110523:r:TOR signaling pathway", "R-CEL-72649:r:Translation initiation complex formation", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SPO-429947:r:Deadenylation of mRNA", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-429947:r:Deadenylation of mRNA", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-429947:r:Deadenylation of mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-72649:r:Translation initiation complex formation", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-166208:r:mTORC1-mediated signalling", "R-MMU-429947:r:Deadenylation of mRNA", "R-MMU-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-DME-166208:r:mTORC1-mediated signalling", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72649:r:Translation initiation complex formation", "R-DDI-166208:r:mTORC1-mediated signalling", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DRE-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-166208:r:mTORC1-mediated signalling", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression"], "type": "Homologous_superfamily"}, "IPR023399": {"description": "Baseplate-like, two-layer sandwich fold", "go_ids": [], "go_terms": [], "name": "Baseplate-like_2-layer_sand", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023400": {"description": "DNA recombination and repair protein RecA, C-terminal, superfamily", "go_ids": [], "go_terms": [], "name": "RecA_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023401": {"description": "Ornithine cyclodeaminase, N-terminal", "go_ids": [], "go_terms": [], "name": "ODC_N", "pathway_ids": ["R-SCE-71064", "R-RNO-71064", "R-MMU-71064", "R-DDI-71064", "R-BTA-71064", "R-HSA-71064", "R-SPO-71064"], "pathways": ["R-SCE-71064:r:Lysine catabolism", "R-RNO-71064:r:Lysine catabolism", "R-MMU-71064:r:Lysine catabolism", "R-DDI-71064:r:Lysine catabolism", "R-BTA-71064:r:Lysine catabolism", "R-HSA-71064:r:Lysine catabolism", "R-SPO-71064:r:Lysine catabolism"], "type": "Homologous_superfamily"}, "IPR023402": {"description": "Uncharacterised protein MG237, central domain", "go_ids": [], "go_terms": [], "name": "Uncharacterised_MG237_central", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023403": {"description": "Uncharacterised protein MG237, N-terminal", "go_ids": [], "go_terms": [], "name": "Uncharacterised_MG237_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023404": {"description": "Radical SAM, alpha/beta horseshoe", "go_ids": [], "go_terms": [], "name": "rSAM_horseshoe", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Homologous_superfamily"}, "IPR023405": {"description": "DNA topoisomerase, type IA, core domain", "go_ids": [], "go_terms": [], "name": "Topo_IA_core_domain", "pathway_ids": ["R-DDI-5693616", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-DDI-5693607", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-9913635"], "pathways": ["R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR023407": {"description": "Small ribosomal subunit protein eS27, zinc-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_eS27_Zn-bd_dom_sf", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-MMU-2467813", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-MMU-68877", "R-RNO-1799339", "R-HSA-72695", "R-RNO-72695", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-CEL-72706", "R-BTA-2500257", "R-BTA-72695", "R-CEL-9954714", "R-CEL-9954716", "R-SCE-72702", "R-BTA-141444", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-BTA-156827", "R-MMU-6791226", "R-MMU-141444", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-DDI-72695", "R-CEL-1799339", "R-BTA-72702", "R-HSA-141444", "R-HSA-72706", "R-HSA-9648025", "R-HSA-9735869", "R-HSA-72702", "R-RNO-5663220", "R-CEL-156827", "R-RNO-6791226", "R-RNO-72649", "R-HSA-6791226", "R-RNO-975956", "R-CEL-72649", "R-SPO-156827", "R-RNO-2467813", "R-HSA-9954714", "R-BTA-9648025", "R-BTA-72649", "R-SPO-72689", "R-MMU-5663220", "R-MMU-1799339", "R-RNO-141444", "R-DDI-72702", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DDI-72689", "R-CEL-72689", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-BTA-5663220", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-2467813", "R-BTA-72706", "R-SCE-975957", "R-HSA-68877", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-MMU-9648025", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-MMU-2500257", "R-SCE-156827", "R-MMU-72702", "R-RNO-68877", "R-HSA-2500257", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-HSA-9754678", "R-HSA-72649", "R-BTA-1799339", "R-MMU-156827", "R-BTA-9954714", "R-SCE-72649", "R-HSA-975957", "R-BTA-975956", "R-HSA-5663220", "R-RNO-9648025", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-72649:r:Translation initiation complex formation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-72649:r:Translation initiation complex formation", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-68877:r:Mitotic Prometaphase", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR023408": {"description": "Mechanosensitive ion channel 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"R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-170984:r:ARMS-mediated activation", "R-RNO-165159:r:MTOR signalling", "R-RNO-5673000:r:RAF activation", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-GGA-3371511:r:HSF1 activation", "R-MMU-170968:r:Frs2-mediated activation", "R-MMU-392517:r:Rap1 signalling", "R-CEL-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-205025:r:NADE modulates death signalling", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-3371511:r:HSF1 activation", "R-RNO-3371511:r:HSF1 activation", 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"PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Family"}, "IPR023509": {"description": "D-aminoacyl-tRNA deacylase-like superfamily", "go_ids": [], "go_terms": [], "name": "DTD-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR023517": {"description": "Amino acid/peptide transporter family, dipeptide and tripeptide permease A", "go_ids": ["GO:1904680", "GO:0006857", "GO:0016020"], "go_terms": ["GO:1904680:peptide transmembrane transporter activity:F", "GO:0006857:oligopeptide transport:P", "GO:0016020:membrane:C"], "name": "AA/pep_transptr_DtpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023526": {"description": "Sulphur relay, TusB", "go_ids": ["GO:0002143", "GO:0005737"], "go_terms": ["GO:0002143:tRNA wobble position uridine thiolation:P", "GO:0005737:cytoplasm:C"], "name": "Sulphur_relay_TusB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023527": {"description": "Adaptive-response sensory-kinase SasA", "go_ids": ["GO:0016772"], "go_terms": ["GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "Kinase_SasA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023529": {"description": "RNA chaperone ProQ", "go_ids": ["GO:0003723", "GO:0010608", "GO:0034057", "GO:0033592"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0010608:post-transcriptional regulation of gene expression:P", "GO:0034057:RNA strand-exchange activity:F", "GO:0033592:RNA strand annealing activity:F"], "name": "ProQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023532": {"description": "H/ACA ribonucleoprotein complex subunit Nop10 , archaeal-type", "go_ids": ["GO:0001522", "GO:0030515", "GO:0042254"], "go_terms": ["GO:0001522:pseudouridine synthesis:P", "GO:0030515:snoRNA binding:F", "GO:0042254:ribosome biogenesis:P"], "name": "Nop10_arc-typ", "pathway_ids": [], "pathways": [], 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"name": "Subtilisin_inhibitor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023550": {"description": "PKHD-type hydroxylase", "go_ids": ["GO:0016706"], "go_terms": ["GO:0016706:2-oxoglutarate-dependent dioxygenase activity:F"], "name": "PKHD_hydroxylase", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR023558": {"description": "Tryptophan RNA-binding attenuator protein domain", "go_ids": [], "go_terms": [], "name": "Trp_RNA-bd_attenuator_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023559": {"description": "Flagellar transcriptional activator FlhD", "go_ids": ["GO:0044780", "GO:0045893"], "go_terms": ["GO:0044780:bacterial-type flagellum assembly:P", "GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "Flagellar_FlhD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023561": {"description": "Carbonic anhydrase, alpha-class", "go_ids": ["GO:0004089", "GO:0008270"], "go_terms": ["GO:0004089:carbonate dehydratase activity:F", "GO:0008270:zinc ion binding:F"], "name": "Carbonic_anhydrase_a-class", "pathway_ids": ["PWY-5743", "PWY-5789", "PWY-7115", "PWY-6142", "PWY-7117", "PWY-241", "PWY-5744", "R-HSA-9925563", "R-GGA-1475029", "R-MMU-1237044", "R-RNO-1237044", "R-HSA-1247673", "R-RNO-1247673", "R-BTA-1475029", "R-HSA-1234158", "R-MMU-1247673", "R-GGA-1247673", "R-HSA-8950505", "R-HSA-1237044", "R-DRE-1247673", "R-BTA-1247673", "R-GGA-1237044", "R-HSA-1475029", "R-MMU-1475029", "R-DRE-1237044", "R-CEL-1237044", "R-CEL-1475029", "R-DRE-1475029", "R-BTA-1237044", "R-CEL-1247673", "R-RNO-1475029"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-241:t:C4 photosynthetic carbon assimilation cycle, NADP-ME type", "PWY-5744:t:glyoxylate assimilation", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-GGA-1475029:r:Reversible hydration of carbon dioxide", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-1475029:r:Reversible hydration of carbon dioxide", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-GGA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DRE-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-GGA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-1475029:r:Reversible hydration of carbon dioxide", "R-MMU-1475029:r:Reversible hydration of carbon dioxide", "R-DRE-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-CEL-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-CEL-1475029:r:Reversible hydration of carbon dioxide", "R-DRE-1475029:r:Reversible hydration of carbon dioxide", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-CEL-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1475029:r:Reversible hydration of carbon dioxide"], "type": "Family"}, "IPR023562": {"description": "Clp protease proteolytic subunit /Translocation-enhancing protein TepA", "go_ids": [], "go_terms": [], "name": "ClpP/TepA", "pathway_ids": ["R-CEL-9837999", "R-HSA-9837999", "R-BTA-9837999", "R-MMU-9837999"], "pathways": ["R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation"], "type": "Family"}, "IPR023566": {"description": "Peptidyl-prolyl cis-trans isomerase Fpr3/Fpr4-like", "go_ids": ["GO:0003755"], "go_terms": ["GO:0003755:peptidyl-prolyl cis-trans isomerase activity:F"], "name": "PPIase_Fpr3/Fpr4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023569": {"description": "Prokineticin domain", "go_ids": [], "go_terms": [], "name": "Prokineticin_domain", "pathway_ids": ["R-MMU-416476", "R-RNO-375276", "R-HSA-375276", "R-MMU-375276", "R-HSA-416476", "R-RNO-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events"], "type": "Domain"}, "IPR023572": {"description": "Archease domain", "go_ids": [], "go_terms": [], "name": "Archease_dom", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR023573": {"description": "Large ribosomal subunit protein eL20 domain", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_eL20_dom", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-DRE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-DRE-9954714", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-DRE-1799339", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-975956", "R-DRE-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-BTA-9954709", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR023574": {"description": "Large ribosomal subunit protein uL4 domain superfamily", "go_ids": ["GO:0006412", "GO:0003735", "GO:0005840"], "go_terms": ["GO:0006412:translation:P", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C"], "name": "Ribosomal_uL4_dom_sf", "pathway_ids": ["R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-BTA-9937383", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-MMU-5389840", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-9937383", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-5389840", "R-BTA-72706", "R-SCE-975957", "R-DRE-9937383", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-DRE-5419276", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-9937383", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-DRE-5389840", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-MMU-5419276", "R-BTA-5419276", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012", "R-HSA-5419276", "R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-HSA-5368286", "R-CEL-72706", "R-HSA-5389840", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-RNO-975957", "R-BTA-156827"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-5419276:r:Mitochondrial translation termination", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-72689:r:Formation of 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"R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) 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complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-72649:r:Translation initiation complex formation", "R-GGA-72649:r:Translation initiation complex formation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", 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the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-72649:r:Translation initiation complex formation", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR023577": {"description": "CYTH domain", "go_ids": [], "go_terms": [], "name": "CYTH_domain", "pathway_ids": ["R-RNO-196819", "R-HSA-196819", "R-MMU-196819", "R-BTA-196819"], "pathways": ["R-RNO-196819:r:Vitamin B1 (thiamin) metabolism", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Domain"}, "IPR023578": {"description": "Ras guanine nucleotide exchange factor domain superfamily", "go_ids": [], "go_terms": [], "name": "Ras_GEF_dom_sf", "pathway_ids": ["R-HSA-9607240", "R-MMU-180336", "R-BTA-5673001", "R-HSA-2871796", "R-HSA-912631", "R-MMU-210993", "R-HSA-9027284", "R-HSA-442982", "R-CEL-9607240", "R-DDI-5213460", "R-MMU-5654706", "R-SCE-8980692", "R-HSA-8853659", "R-DME-74751", "R-MMU-8851805", "R-DDI-5673000", "R-MMU-5673001", "R-MMU-186763", "R-RNO-193648", "R-DME-1433559", "R-MMU-167044", "R-CEL-1855204", "R-DME-9607240", "R-DME-9013149", "R-HSA-983695", "R-HSA-2424491", "R-MMU-392517", "R-DDI-5673001", "R-HSA-416482", "R-RNO-9013148", "R-HSA-8983432", "R-SCE-193648", "R-CEL-74751", 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"R-HSA-9664565", "R-HSA-5655302", "R-CEL-5654693", "R-MMU-2428933", "R-DDI-193648", "R-DME-5654704", "R-HSA-9665686", "R-MMU-1433557", "R-HSA-210993", "R-MMU-8853659", "R-MMU-5654700", "R-DME-5654688", "R-SCE-354192", "R-HSA-5673001", "R-SCE-9013148", "R-HSA-9013149", "R-DME-2871796", "R-HSA-8980692", "R-SCE-9035034", "R-DME-8853659", "R-HSA-9703648", "R-HSA-381676", "R-CEL-1963640", "R-DME-1963640", "R-BTA-354192", "R-CEL-186763", "R-MMU-5654688", "R-DRE-416482", "R-HSA-5654704", "R-SCE-392517", "R-MMU-375165", "R-CEL-375165", "R-MMU-1169092", "R-MMU-2179392", "R-HSA-167044", "R-SCE-9013423", "R-DME-5654700", "R-HSA-74751", "R-MMU-422356", "R-DME-5654693", "R-MMU-9013148", "R-HSA-375165", "R-HSA-1250347", "R-DDI-9013149", "R-DME-2428933", "R-MMU-9842663", "R-CEL-9013149", "R-HSA-2871837", "R-DDI-381676", "R-HSA-9673770", "R-HSA-114508", "R-CEL-5654706", "R-HSA-1169092", "R-DME-2871809", "R-HSA-1236382", "R-DRE-9013149", "R-CEL-5654699", "R-DME-1250347", "R-SCE-9013424", "R-MMU-1855204", "R-HSA-8851805", "R-MMU-5654719", "R-HSA-9028731", "R-HSA-171007", "R-HSA-354192", "R-HSA-193648", "R-RNO-171007", "R-DDI-171007", "R-DDI-3295583", "R-CEL-392517", "R-HSA-5654706", "R-HSA-354194", "R-HSA-9679191", "R-MMU-983695", "R-DDI-1169092", "R-HSA-1433557", "R-RNO-381676", "R-CEL-381676", "R-CEL-180336", "R-HSA-186763", "R-RNO-1169092", "R-HSA-9703465", "R-DRE-9013148", "R-MMU-2871809", "R-HSA-112412", "R-MMU-416482", "R-MMU-2424491", "R-RNO-1855204", "R-DME-179812", "R-DME-9013423", "R-CEL-5654704"], "pathways": ["R-HSA-9607240:r:FLT3 Signaling", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-CEL-9607240:r:FLT3 Signaling", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-DME-74751:r:Insulin receptor signalling cascade", "R-MMU-8851805:r:MET activates RAS signaling", "R-DDI-5673000:r:RAF activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-RNO-193648:r:NRAGE signals death through JNK", "R-DME-1433559:r:Regulation of KIT signaling", "R-MMU-167044:r:Signalling to RAS", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DME-9607240:r:FLT3 Signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2424491:r:DAP12 signaling", "R-MMU-392517:r:Rap1 signalling", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SCE-193648:r:NRAGE signals death through JNK", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-171007:r:p38MAPK events", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-8851805:r:MET activates RAS signaling", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-MMU-354192:r:Integrin signaling", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-SCE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-354192:r:Integrin signaling", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-112412:r:SOS-mediated signalling", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-112412:r:SOS-mediated signalling", "R-DDI-392517:r:Rap1 signalling", "R-DME-167044:r:Signalling to RAS", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-74749:r:Signal attenuation", "R-HSA-9842663:r:Signaling by LTK", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-DME-74749:r:Signal attenuation", "R-XTR-354192:r:Integrin signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-186763:r:Downstream signal transduction", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-74749:r:Signal attenuation", "R-MMU-1963640:r:GRB2 events in 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"R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-RNO-392517:r:Rap1 signalling", "R-DME-210993:r:Tie2 Signaling", "R-DME-2424491:r:DAP12 signaling", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-XTR-1169092:r:Activation of RAS in B cells", "R-BTA-392517:r:Rap1 signalling", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-XTR-392517:r:Rap1 signalling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-210993:r:Tie2 Signaling", "R-MMU-8853659:r:RET signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-SCE-354192:r:Integrin signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-9035034:r:RHOF GTPase cycle", "R-DME-8853659:r:RET signaling", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-354192:r:Integrin signaling", "R-CEL-186763:r:Downstream signal transduction", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-SCE-392517:r:Rap1 signalling", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-MMU-1169092:r:Activation of RAS in B cells", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-167044:r:Signalling to RAS", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-MMU-422356:r:Regulation of insulin secretion", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-9842663:r:Signaling by LTK", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-1169092:r:Activation of RAS in B cells", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-SCE-9013424:r:RHOV GTPase cycle", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-171007:r:p38MAPK events", "R-HSA-354192:r:Integrin signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-171007:r:p38MAPK events", "R-DDI-171007:r:p38MAPK events", "R-DDI-3295583:r:TRP channels", "R-CEL-392517:r:Rap1 signalling", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-1169092:r:Activation of RAS in B cells", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-1169092:r:Activation of RAS in B cells", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-112412:r:SOS-mediated signalling", 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"R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a 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"R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", 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"R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of 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"R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Homologous_superfamily"}, "IPR023804": {"description": "Protein of unknown function DUF3792, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF3792_TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023805": {"description": "Uncharacterised protein family, spore photo-product lyase-related", "go_ids": [], "go_terms": [], "name": "Uncharacterised_Spl-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023806": {"description": "Conserved hypothetical protein CHP03905", "go_ids": [], "go_terms": [], "name": "CHP03905", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023807": {"description": "Peptide modification radical SAM enzyme, putative", "go_ids": [], "go_terms": [], "name": "Peptide_mod_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023808": {"description": "Nitrile hydratase accessory protein, putative", "go_ids": [], "go_terms": [], "name": "Nitrile_Hydratase_acc_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023809": {"description": "Thiopeptide-type bacteriocin biosynthesis domain", "go_ids": [], "go_terms": [], "name": "Thiopep_bacteriocin_synth_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023810": {"description": "Conserved hypothetical protein CHP03894", "go_ids": [], "go_terms": [], "name": "CHP03894", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023811": {"description": "Conserved hypothetical protein CHP04076", "go_ids": [], "go_terms": [], "name": "CHP04076", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023812": {"description": "Conserved hypothetical protein CHP04002", "go_ids": [], "go_terms": [], "name": "CHP04002", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023813": {"description": "Heme sensing membrane protein HsmA-like", "go_ids": [], "go_terms": [], "name": "HsmA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023814": {"description": "His-Xaa-Ser system protein", "go_ids": [], "go_terms": [], "name": "His-Xaa-Ser_sys", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023815": {"description": "CRISPR-associated protein Csx19", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Csx19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023816": {"description": "CRISPR-associated protein CYA0889", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_CYA0889", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023817": {"description": "Frankia-40 domain", "go_ids": [], "go_terms": [], "name": "Frankia_40_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023818": {"description": "Conserved hypothetical protein CHP03890, nif11/cupin domain-containing", "go_ids": [], "go_terms": [], "name": "Nif11_cupin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023819": {"description": "Peptide-modifying radical SAM enzyme putative, AF0577", "go_ids": [], "go_terms": [], "name": "Pep-mod_rSAM_AF0577", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023820": {"description": "Radical SAM GDL-associated", "go_ids": [], "go_terms": [], "name": "rSAM_GDL-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023821": {"description": "Radical SAM, TatD-associated", "go_ids": [], "go_terms": [], "name": "rSAM_TatD-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023822": {"description": "Radical SAM, TatD-associated, bacteria", "go_ids": [], "go_terms": [], "name": "rSAM_TatD-assoc_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023823": {"description": "Conserved hypothetical protein CHP04066, peptide maturation system", "go_ids": [], "go_terms": [], "name": "CHP04066_peptide_maturation", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023824": {"description": "Conserved hypothetical protein CHP04073, exosortase-affiliated", "go_ids": [], "go_terms": [], "name": "CHP04073_exosortase-affil", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023825": {"description": "CRISPR-associated RAMP BGP1436", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_RAMP_BGP1436", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023826": {"description": "Rhomboid-like serine protease, proteobacteria", "go_ids": [], "go_terms": [], "name": "Rhom-like_SP_proteobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023829": {"description": "Poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD", "go_ids": ["GO:0043709"], "go_terms": ["GO:0043709:cell adhesion involved in single-species biofilm formation:P"], "name": "PGA_PgaD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023830": {"description": "Peptidase S8A, PatG", "go_ids": [], "go_terms": [], "name": "Peptidase_S8A_PatG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023831": {"description": "Serine peptidase MXAN_5808-like", "go_ids": [], "go_terms": [], "name": "MXAN_5808-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023832": {"description": "Histidine triad protein", "go_ids": [], "go_terms": [], "name": "His_triad_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023833": {"description": "SipW-dependent-type signal peptide", "go_ids": [], "go_terms": [], "name": "Signal_pept_SipW-depend-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023834": {"description": "Type VII secretion system peptidase S8A, mycosin", "go_ids": [], "go_terms": [], "name": "T7SS_pept_S8A_mycosin", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR023835": {"description": "Type VII secretion system AAA-ATPase, EccA", "go_ids": [], "go_terms": [], "name": "T7SS_EccA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023836": {"description": "EccCa-like, Actinobacteria", "go_ids": [], "go_terms": [], "name": "EccCa-like_Actinobacteria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023837": {"description": "EccCb-like, Actinobacteria", "go_ids": [], "go_terms": [], "name": "EccCb-like_Actinobacteria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023838": {"description": "Type VII secretion system EsaA", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "T7SS_EsaA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023839": {"description": "Firmicutes EssC, C-terminal", "go_ids": [], "go_terms": [], "name": "Firmicutes_EssC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023840": {"description": "Type VII secretion system Rv3446c", "go_ids": [], "go_terms": [], "name": "T7SS_Rv3446c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023841": {"description": "Bacillithiol biosynthesis deacetylase BshB2", "go_ids": [], "go_terms": [], "name": "BshB2", "pathway_ids": ["PWY-7403", "PWY-8229", "PWY-7571", "PWY-7850", "PWY-7430", "PWY-8418", "PWY-7496", "PWY-8453", "PWY-8432", "PWY-8293", "PWY-5846", "PWY-7018", "PWY-5497", "PWY-8431", "PWY-1822", "PWY-7821", "PWY-6409", "PWY-6899", "PWY-7652", "PWY-5784", "PWY-7771", "PWY-8402"], "pathways": ["PWY-7403:t:tetramethylpyrazine degradation", "PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7850:t:taurine biosynthesis II", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-8418:t:S-benzyl-L-cysteine degradation", "PWY-7496:t:linuron degradation", "PWY-8453:t:D-glutamate degradation", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-8293:t:alazopeptin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8431:t:L-mimosine degradation", "PWY-1822:t:indole-3-acetate activation I", "PWY-7821:t:tunicamycin biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-6899:t:base-degraded thiamine salvage", "PWY-7652:t:echinocandin B degradation", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-7771:t:butachlor degradation", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR023842": {"description": "Bacillithiol biosynthesis deacetylase, BshB1", "go_ids": ["GO:0019213", "GO:0071793"], "go_terms": ["GO:0019213:deacetylase activity:F", "GO:0071793:bacillithiol biosynthetic process:P"], "name": "Bacillithiol_biosynth_BshB1", "pathway_ids": ["PWY-7403", "PWY-8229", "PWY-7571", "PWY-7850", "PWY-7430", "PWY-8418", "PWY-7496", "PWY-8453", "PWY-8432", "PWY-8293", "PWY-5846", "PWY-7018", "PWY-5497", "PWY-8431", "PWY-1822", "PWY-7821", "PWY-6409", "PWY-6899", "PWY-7652", "PWY-5784", "PWY-7771", "PWY-8402"], "pathways": ["PWY-7403:t:tetramethylpyrazine degradation", "PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7850:t:taurine biosynthesis II", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-8418:t:S-benzyl-L-cysteine degradation", "PWY-7496:t:linuron degradation", "PWY-8453:t:D-glutamate degradation", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-8293:t:alazopeptin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8431:t:L-mimosine degradation", "PWY-1822:t:indole-3-acetate activation I", "PWY-7821:t:tunicamycin biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-6899:t:base-degraded thiamine salvage", "PWY-7652:t:echinocandin B degradation", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-7771:t:butachlor degradation", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR023843": {"description": "CRISPR-associated protein Cas1, cyanobacteria-type", "go_ids": ["GO:0046872", "GO:0004520", "GO:0043571"], "go_terms": ["GO:0046872:metal ion binding:F", "GO:0004520:DNA endonuclease activity:F", "GO:0043571:maintenance of CRISPR repeat elements:P"], "name": "CRISPR-assoc_Cas1_cyanobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023844": {"description": "CRISPR-associated protein Cas1, MYXAN subtype", "go_ids": ["GO:0043571", "GO:0004520", "GO:0046872"], "go_terms": ["GO:0043571:maintenance of CRISPR repeat elements:P", "GO:0004520:DNA endonuclease activity:F", "GO:0046872:metal ion binding:F"], "name": "CRISPR-assoc_Cas1_MYXAN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023845": {"description": "Domain of unknown function DUF3817, transmembrane", "go_ids": [], "go_terms": [], "name": "DUF3817_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023846": {"description": "Conserved hypothetical protein CHP04042, MSMEG0570", "go_ids": [], "go_terms": [], "name": "CHP04042_MSMEG0570", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023847": {"description": "MSMEG_0572 family nitrogen starvation response protein", "go_ids": [], "go_terms": [], "name": "MSMEG0572", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023848": {"description": "TasA anchoring/assembly protein", "go_ids": ["GO:0097311"], "go_terms": ["GO:0097311:bacterial biofilm matrix:C"], "name": "TasA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023849": {"description": "TQXA domain", "go_ids": [], "go_terms": [], "name": "TQXA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023850": {"description": "Peptide chaperone MftB", "go_ids": [], "go_terms": [], "name": "MftB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023851": {"description": "Transcriptional regulator, TetR-type", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_TetR-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023852": {"description": "Metalloproteinase lipoprotein, BF0631", "go_ids": [], "go_terms": [], "name": "Metalloproteinase_lipop_BF0631", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023853": {"description": "Poly-beta-1,6 N-acetyl-D-glucosamine synthase PgaC/IcaA", "go_ids": ["GO:0043708", "GO:0008375"], "go_terms": ["GO:0043708:cell adhesion involved in biofilm formation:P", "GO:0008375:acetylglucosaminyltransferase activity:F"], "name": "PGA_PgaC/IcaA", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR023854": {"description": "Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB", "go_ids": ["GO:0043708", "GO:0016810"], "go_terms": ["GO:0043708:cell adhesion involved in biofilm formation:P", "GO:0016810:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:F"], "name": "PGA_deacetylase_PgaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023856": {"description": "Bacilliredoxin reductase Bdr", "go_ids": [], "go_terms": [], "name": "Bdr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023858": {"description": "6-carboxymethyl-5-methyl-4-hydroxy-2-pyridinol synthase HcgA", "go_ids": [], "go_terms": [], "name": "HcgA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023860": {"description": "[FeFe]-hydrogenase system regulator TM1266", "go_ids": [], "go_terms": [], "name": "FeFe-hyd_TM1266", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023862": {"description": "Conserved hypothetical protein CHP03960, radical SAM", "go_ids": [], "go_terms": [], "name": "CHP03960_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023863": {"description": "Archaeal radical SAM protein, PTO1314 family", "go_ids": [], "go_terms": [], "name": "rSAM_PTO1314", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023866": {"description": "2,3-diaminopropionate biosynthesis protein SbnB", "go_ids": ["GO:0016639", "GO:0019290"], "go_terms": ["GO:0016639:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor:F", "GO:0019290:siderophore biosynthetic process:P"], "name": "SbnB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023867": {"description": "Anaerobic sulphatase maturase, radical SAM", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Sulphatase_maturase_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023868": {"description": "7-carboxy-7-deazaguanine synthase, Clostridial form", "go_ids": [], "go_terms": [], "name": "7-CO-7-deazaGua_synth_put_Clo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023869": {"description": "tRNA adenosine deaminase-associated protein", "go_ids": [], "go_terms": [], "name": "tRNA_Adeno_NH3ase_assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023870": {"description": "Poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA", "go_ids": ["GO:1901515"], "go_terms": ["GO:1901515:poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity:F"], "name": "PGA_export_porin_PgaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023871": {"description": "Mycofactocin precursor peptide peptidase", "go_ids": [], "go_terms": [], "name": "MftE", "pathway_ids": ["PWY-8122"], "pathways": ["PWY-8122:t:mycofactocin biosynthesis"], "type": "Family"}, "IPR023872": {"description": "Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase", "go_ids": ["GO:0016811"], "go_terms": ["GO:0016811:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides:F"], "name": "PNAG_deacetylase", "pathway_ids": ["PWY-7403", "PWY-8229", "PWY-7571", "PWY-7850", "PWY-7430", "PWY-8418", "PWY-7496", "PWY-8453", "PWY-8432", "PWY-8293", "PWY-5846", "PWY-7018", "PWY-5497", "PWY-8431", "PWY-1822", "PWY-7821", "PWY-6409", "PWY-6899", "PWY-7652", "PWY-5784", "PWY-7771", "PWY-8402"], "pathways": ["PWY-7403:t:tetramethylpyrazine degradation", "PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7850:t:taurine biosynthesis II", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-8418:t:S-benzyl-L-cysteine degradation", "PWY-7496:t:linuron degradation", "PWY-8453:t:D-glutamate degradation", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-8293:t:alazopeptin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8431:t:L-mimosine degradation", "PWY-1822:t:indole-3-acetate activation I", "PWY-7821:t:tunicamycin biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-6899:t:base-degraded thiamine salvage", "PWY-7652:t:echinocandin B degradation", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-7771:t:butachlor degradation", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Family"}, "IPR023873": {"description": "[FeFe]-hydrogenase H-cluster maturation GTPase HydF", "go_ids": [], "go_terms": [], "name": "FeFe-hyd_GTPase_HydF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023874": {"description": "DNA modification/repair radical SAM protein, putative", "go_ids": [], "go_terms": [], "name": "DNA_rSAM_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023875": {"description": "DNA repair protein, putative", "go_ids": [], "go_terms": [], "name": "DNA_repair_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023877": {"description": "Pyrrolysyl-tRNA ligase, C-terminal", "go_ids": ["GO:0004812"], "go_terms": ["GO:0004812:aminoacyl-tRNA ligase activity:F"], "name": "Pyrrolysyl-tRNA_ligase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023878": {"description": "Pyrrolysyl-tRNA ligase, N-terminal", "go_ids": ["GO:0004812"], "go_terms": ["GO:0004812:aminoacyl-tRNA ligase activity:F"], "name": "Pyrrolysyl-tRNA_ligase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023879": {"description": "Quinohemoprotein amine dehydrogenase, beta subunit", "go_ids": [], "go_terms": [], "name": "QH-AmDH_bsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023880": {"description": "Benzylsuccinate synthase activating enzyme", "go_ids": [], "go_terms": [], "name": "Benzylsucc_Synthase_activating", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023881": {"description": "N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA", "go_ids": ["GO:0016757", "GO:0071793"], "go_terms": ["GO:0016757:glycosyltransferase activity:F", "GO:0071793:bacillithiol biosynthetic process:P"], "name": "Thiol_BshA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023882": {"description": "Colanic acid biosynthesis WcaM", "go_ids": [], "go_terms": [], "name": "Colanic_acid_synth_WcaM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023883": {"description": "Conserved hypothetical protein CHP03980, redox-disulphide", "go_ids": [], "go_terms": [], "name": "CHP03980_redox-disulphide", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023884": {"description": "Colanic acid biosynthesis, glycosyl transferase, WcaL", "go_ids": [], "go_terms": [], "name": "Colanic_acid_synth_WcaL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023885": {"description": "4Fe4S-binding SPASM domain", "go_ids": [], "go_terms": [], "name": "4Fe4S-binding_SPASM_dom", "pathway_ids": ["PWY-6420"], "pathways": ["PWY-6420:t:pyrroloquinoline quinone biosynthesis"], "type": "Domain"}, "IPR023886": {"description": "Quinohemoprotein amine dehydrogenase, gamma subunit maturation protein", "go_ids": [], "go_terms": [], "name": "QH-AmDH_gsu_maturation", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023887": {"description": "Quinohemoprotein amine dehydrogenase, alpha subunit", "go_ids": [], "go_terms": [], "name": "QH-AmDH_asu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023888": {"description": "Sporulation delaying protein C-like", "go_ids": [], "go_terms": [], "name": "SdpC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023889": {"description": "TOMM system kinase/cyclase fusion protein", "go_ids": [], "go_terms": [], "name": "TOMM_kin_cyc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023890": {"description": "Pyrrolysine biosynthesis protein PylC", "go_ids": ["GO:0071524"], "go_terms": ["GO:0071524:pyrrolysine biosynthetic process:P"], "name": "Pyrrolys_PylC", "pathway_ids": ["PWY-6994"], "pathways": ["PWY-6994:t:L-pyrrolysine biosynthesis"], "type": "Family"}, "IPR023891": {"description": "Pyrrolysine biosynthesis protein PylB", "go_ids": ["GO:0071524"], "go_terms": ["GO:0071524:pyrrolysine biosynthetic process:P"], "name": "Pyrrolys_PylB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023892": {"description": "Cyclic nucleotide-binding domain protein", "go_ids": [], "go_terms": [], "name": "cNMP-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023893": {"description": "His-Xaa-Ser system-associated, MauG-like protein", "go_ids": [], "go_terms": [], "name": "MauG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023894": {"description": "Sporulation delaying protein SdpB", "go_ids": [], "go_terms": [], "name": "Sporulation_SdpB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023895": {"description": "Thiazolylpeptide-type bacteriocin precursor", "go_ids": [], "go_terms": [], "name": "Thiopep_bacteriocin_prcur", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023896": {"description": "D-alanyl-lipoteichoic acid biosynthesis DltD, Firmicutes", "go_ids": [], "go_terms": [], "name": "LTA_DltD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023897": {"description": "Spore photoproduct lyase, firmicutes", "go_ids": ["GO:0003913"], "go_terms": ["GO:0003913:DNA photolyase activity:F"], "name": "SPL_firmicutes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023898": {"description": "Putative exported peptide YydF-like", "go_ids": [], "go_terms": [], "name": "YydF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023900": {"description": "Nitrile hydratase alpha subunit /Thiocyanate hydrolase gamma subunit", "go_ids": [], "go_terms": [], "name": "CN_Hdrtase_asu/SCN_Hdrlase_gsu", "pathway_ids": ["PWY-5025", "PWY-581", "PWY-7308"], "pathways": ["PWY-5025:t:indole-3-acetate biosynthesis IV (bacteria)", "PWY-581:t:indole-3-acetate biosynthesis II", "PWY-7308:t:acrylonitrile degradation I"], "type": "Family"}, "IPR023901": {"description": "Thiocyanate hydrolase, gamma subunit", "go_ids": [], "go_terms": [], "name": "Thiocyan_Hydrolase_gsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023902": {"description": "Sporulation delaying protein SdpA", "go_ids": [], "go_terms": [], "name": "Sporulation_SdpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023903": {"description": "Cyclised secreted peptide", "go_ids": [], "go_terms": [], "name": "Cyclised_pep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023904": {"description": "Putative peptide biosynthesis protein YydG", "go_ids": [], "go_terms": [], "name": "YydG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023906": {"description": "Radical SAM target protein, putative", "go_ids": [], "go_terms": [], "name": "rSAM_target_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023907": {"description": "Non-F420 flavinoid oxidoreductase", "go_ids": [], "go_terms": [], "name": "Non-F420_Flavin_OxRdtase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023908": {"description": "xxxLxxG heptad repeat", "go_ids": [], "go_terms": [], "name": "xxxLxxG_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR023909": {"description": "F420-dependent oxidoreductase, NP1902A", "go_ids": [], "go_terms": [], "name": "F420_NP1902A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023910": {"description": "Colanic acid biosynthesis, glycosyl transferase, WcaI", "go_ids": [], "go_terms": [], "name": "Colanic_acid_synth_WcaI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023911": {"description": "MSMEG_0567/sll0787, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MSMEG_0567/sll0787_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR023912": {"description": "Putative glycyl-radical enzyme activating enzyme YjjW", "go_ids": [], "go_terms": [], "name": "YjjW_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023913": {"description": "Mycofactocin maturase MftC", "go_ids": [], "go_terms": [], "name": "MftC", "pathway_ids": ["PWY-8122"], "pathways": ["PWY-8122:t:mycofactocin biosynthesis"], "type": "Family"}, "IPR023914": {"description": "Pyrrolysine biosynthesis protein PylD", "go_ids": [], "go_terms": [], "name": "Pyrrolys_PylD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023915": {"description": "UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, archaeal-type", "go_ids": ["GO:0003977", "GO:0019134"], "go_terms": ["GO:0003977:UDP-N-acetylglucosamine diphosphorylase activity:F", "GO:0019134:glucosamine-1-phosphate N-acetyltransferase activity:F"], "name": "Bifunctiontional_GlmU_arc-type", "pathway_ids": ["PWY-5514"], "pathways": ["PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II"], "type": "Family"}, "IPR023916": {"description": "Colanic acid biosynthesis, glycosyl transferase, WcaC", "go_ids": [], "go_terms": [], "name": "Colanic_acid_synth_WcaC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023917": {"description": "UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, bacterial-type", "go_ids": [], "go_terms": [], "name": "Bifunctiontional_GlmU_bac-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023918": {"description": "Colanic acid biosynthesis, pyruvyl transferase, WcaK", "go_ids": [], "go_terms": [], "name": "Colanic_acid_synth_WcaK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023919": {"description": "Nitrilase", "go_ids": [], "go_terms": [], "name": "Nitrilase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023920": {"description": "ABC transporter, substrate-binding protein, KPN01854", "go_ids": [], "go_terms": [], "name": "ABC_transptr_sub-bd_KPN01854", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023921": {"description": "Alcohol dehydrogenase, zinc-type, actinomycetes", "go_ids": [], "go_terms": [], "name": "ADH_Zn_actinomycetes", "pathway_ids": ["PWY-7111", "PWY-6313", "PWY-5751", "PWY-5082", "PWY-5486", "PWY-5480", "PWY-6587", "PWY-5078", "PWY-7396", "PWY-3162", "PWY-6802", "PWY-5076", "PWY-6333", "PWY-7013", "PWY-6871", "PWY-5057", "PWY-6342", "PWY-5079"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-6313:t:serotonin degradation", "PWY-5751:t:phenylethanol biosynthesis", "PWY-5082:t:L-methionine degradation III", "PWY-5486:t:pyruvate fermentation to ethanol II", "PWY-5480:t:pyruvate fermentation to ethanol I", "PWY-6587:t:pyruvate fermentation to ethanol III", "PWY-5078:t:L-isoleucine degradation II", "PWY-7396:t:butanol and isobutanol biosynthesis (engineered)", "PWY-3162:t:L-tryptophan degradation V (side chain pathway)", "PWY-6802:t:salidroside biosynthesis", "PWY-5076:t:L-leucine degradation III", "PWY-6333:t:acetaldehyde biosynthesis I", "PWY-7013:t:(S)-propane-1,2-diol degradation", "PWY-6871:t:3-methylbutanol biosynthesis (engineered)", "PWY-5057:t:L-valine degradation II", "PWY-6342:t:noradrenaline and adrenaline degradation", "PWY-5079:t:L-phenylalanine degradation III"], "type": "Family"}, "IPR023922": {"description": "Sulphate-starvation-induced SfnB", "go_ids": [], "go_terms": [], "name": "S04_starv_induced_SfnB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023923": {"description": "Alkylhydroperoxidase domain-containing protein, Avi7169", "go_ids": [], "go_terms": [], "name": "AhpD_Avi7169", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023927": {"description": "2,3-diaminopropionate biosynthesis protein SbnA", "go_ids": [], "go_terms": [], "name": "SbnA", "pathway_ids": ["PWY-7694", "PWY-8381", "PWY-8008", "PWY-7706"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-8381:t:sulfazecin biosynthesis", "PWY-8008:t:staphyloferrin B biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Family"}, "IPR023928": {"description": "His-Xaa-Ser rich protein HxsA-like", "go_ids": [], "go_terms": [], "name": "HxsA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023929": {"description": "Di-heme enzyme MbnH-like", "go_ids": [], "go_terms": [], "name": "MbnH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023930": {"description": "Putative heme d1 biosynthesis protein, NirJ1", "go_ids": [], "go_terms": [], "name": "NirJ1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023932": {"description": "CE1759 family FMN reductase", "go_ids": [], "go_terms": [], "name": "CE1759_FMN_reduct", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023934": {"description": "Luciferase-like monooxygenase, FMN-dependent, putative", "go_ids": [], "go_terms": [], "name": "LLM_FMN-dep_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023935": {"description": "Replication factor C, large subunit", "go_ids": [], "go_terms": [], "name": "Rep_factor-C_lsu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023939": {"description": "Cysteine desulfuration protein SufE", "go_ids": ["GO:0006790", "GO:0016226"], "go_terms": ["GO:0006790:sulfur compound metabolic process:P", "GO:0016226:iron-sulfur cluster assembly:P"], "name": "Cysteine_desulfuration_SufE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023940": {"description": "Dihydrodipicolinate reductase", "go_ids": ["GO:0008839", "GO:0009085"], "go_terms": ["GO:0008839:4-hydroxy-tetrahydrodipicolinate reductase activity:F", "GO:0009085:L-lysine biosynthetic process:P"], "name": "DHDPR_bac", "pathway_ids": ["PWY-5097", "PWY-2942", "PWY-2941"], "pathways": ["PWY-5097:t:L-lysine biosynthesis VI", "PWY-2942:t:L-lysine biosynthesis III", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Family"}, "IPR023943": {"description": "Enolase-phosphatase E1", "go_ids": ["GO:0043874", "GO:0033353", "GO:0000287"], "go_terms": ["GO:0043874:acireductone synthase activity:F", "GO:0033353:L-methionine cycle:P", "GO:0000287:magnesium ion binding:F"], "name": "Enolase-ppase_E1", "pathway_ids": ["R-DRE-1237112", "R-CEL-1237112", "R-SCE-1237112", "R-BTA-1237112", "R-SPO-1237112", "R-RNO-1237112", "R-MMU-1237112", "R-XTR-1237112", "R-DDI-1237112", "R-DME-1237112", "R-HSA-1237112"], "pathways": ["R-DRE-1237112:r:Methionine salvage pathway", "R-CEL-1237112:r:Methionine salvage pathway", "R-SCE-1237112:r:Methionine salvage pathway", "R-BTA-1237112:r:Methionine salvage pathway", "R-SPO-1237112:r:Methionine salvage pathway", "R-RNO-1237112:r:Methionine salvage pathway", "R-MMU-1237112:r:Methionine salvage pathway", "R-XTR-1237112:r:Methionine salvage pathway", "R-DDI-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-HSA-1237112:r:Methionine salvage pathway"], "type": "Family"}, "IPR023946": {"description": "Endo-type membrane-bound lytic murein transglycosylase A", "go_ids": ["GO:0008932", "GO:0016837", "GO:0016998", "GO:0009279"], "go_terms": ["GO:0008932:lytic endotransglycosylase activity:F", "GO:0016837:carbon-oxygen lyase activity, acting on polysaccharides:F", "GO:0016998:cell wall macromolecule catabolic process:P", "GO:0009279:cell outer membrane:C"], "name": "EmtA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023947": {"description": "Glutathione-regulated potassium-efflux system ancillary protein KefG", "go_ids": ["GO:0006813"], "go_terms": ["GO:0006813:potassium ion transport:P"], "name": "K_H_efflux_KefG", "pathway_ids": ["PWY-7999", "PWY-7731"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "PWY-7731:t:superpathway of photosynthetic hydrogen production"], "type": "Family"}, "IPR023948": {"description": "Glutathione-regulated potassium-efflux system ancillary protein KefF", "go_ids": ["GO:0006813"], "go_terms": ["GO:0006813:potassium ion transport:P"], "name": "K_H_efflux_KefF", "pathway_ids": ["PWY-7999", "PWY-7731"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "PWY-7731:t:superpathway of photosynthetic hydrogen production"], "type": "Family"}, "IPR023963": {"description": "Methanobactin precursor, Mb-OB3b", "go_ids": [], "go_terms": [], "name": "Methanobactin_OB3b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023964": {"description": "Bacteriocin precursor, CLOSPO-01332, putative", "go_ids": [], "go_terms": [], "name": "Bacteriocin_CLOSPO-01332_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023965": {"description": "Capreomycidine synthase", "go_ids": [], "go_terms": [], "name": "Capreomycidine_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023966": {"description": "Arginine beta-hydroxylase, Fe2/alpha-ketoglutarate-dependent", "go_ids": [], "go_terms": [], "name": "Arginine_beta-hydroxylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023967": {"description": "Conserved hypothetical protein CHP03996, oxidoreductase", "go_ids": [], "go_terms": [], "name": "CHP03996_oxidoreductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023968": {"description": "Bacteriocin precursor, CLI3235 family, putative", "go_ids": [], "go_terms": [], "name": "Bacteriocin_CLI3235", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023969": {"description": "Conserved hypothetical protein CHP04072, B12-binding/radical SAM-type", "go_ids": [], "go_terms": [], "name": "CHP04072_B12-bd/rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023971": {"description": "Selenoprotein GSU1558/SbtA-like", "go_ids": [], "go_terms": [], "name": "GSU1558/StbA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023972": {"description": "Conserved hypothetical protein CHP04069, acyl carrier-related", "go_ids": [], "go_terms": [], "name": "CHP04069_acyl_carrier-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023973": {"description": "Methanobactin biosynthesis cassette protein MbnC-like", "go_ids": [], "go_terms": [], "name": "MbnC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023974": {"description": "His-Xaa-Ser system protein HxsD", "go_ids": [], "go_terms": [], "name": "HxsD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023975": {"description": "Six-cysteine peptide SCIFF", "go_ids": [], "go_terms": [], "name": "Six-Cys_pep_SCIFF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023976": {"description": "Conserved hypothetical protein CHP04031, Htur1727", "go_ids": [], "go_terms": [], "name": "CHP04031_Htur1727", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023977": {"description": "Copper-binding protein MbnP-like", "go_ids": [], "go_terms": [], "name": "MbnP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023978": {"description": "Glucose-methanol-choline oxidoreductase, bacteria", "go_ids": [], "go_terms": [], "name": "GMC_oxidoreductase_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023979": {"description": "Conserved hypothetical protein CHP04014, B12-binding/radical SAM-type", "go_ids": [], "go_terms": [], "name": "CHP04014_B12-bd/rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023980": {"description": "Conserved hypothetical protein CHP04013, B12-binding/radical SAM-type", "go_ids": [], "go_terms": [], "name": "CHP04013_B12-bd/rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023981": {"description": "Pre-mycofactocin glycosyltransferase", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "MftF", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR023982": {"description": "Conserved hypothetical protein CHP04029, CMD-like", "go_ids": [], "go_terms": [], "name": "CHP04029_CMD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023983": {"description": "DNA sulphur modification system-associated protein 4", "go_ids": [], "go_terms": [], "name": "DNA_S_mod_dnd_assoc_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023984": {"description": "Ribosomal peptide maturation radical SAM protein 1", "go_ids": [], "go_terms": [], "name": "rSAM_ocin_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023985": {"description": "Mycofactocin-dependent oxidoreductase", "go_ids": [], "go_terms": [], "name": "SDR_subfam_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023986": {"description": "Glycosyltransferase, putative, MSMEG0565 family", "go_ids": [], "go_terms": [], "name": "GlycosylTfrase_MSMEG0565", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023987": {"description": "Conserved hypothetical protein CHP03977, oxidoreductase", "go_ids": [], "go_terms": [], "name": "CHP03977_oxidoreductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023988": {"description": "Mycofactocin precursor peptide", "go_ids": [], "go_terms": [], "name": "MftA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023989": {"description": "Pre-mycofactocin synthase", "go_ids": [], "go_terms": [], "name": "MftD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023990": {"description": "Butyryl-CoA:acetate CoA-transferase", "go_ids": ["GO:0019605"], "go_terms": ["GO:0019605:butyrate metabolic process:P"], "name": "Butryl-CoA_acetate_CoA_Tfrase", "pathway_ids": ["PWY-7401", "PWY-5022", "PWY-8326", "PWY-5677", "PWY-7382"], "pathways": ["PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-8326:t:grayanate biosynthesis", "PWY-5677:t:succinate fermentation to butanoate", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)"], "type": "Family"}, "IPR023991": {"description": "Bacteriocin, class IIb, lactobin A/cerein 7B family", "go_ids": [], "go_terms": [], "name": "Bacteriocin_IIb_lactobn/cerein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023992": {"description": "Pre-heme d1 synthase NirJ", "go_ids": ["GO:0003824", "GO:0051539"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "HemeD1_Synth_NirJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023993": {"description": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, archaea", "go_ids": ["GO:0008033", "GO:0051539", "GO:0016829"], "go_terms": ["GO:0008033:tRNA processing:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0016829:lyase activity:F"], "name": "TYW1_archaea", "pathway_ids": ["PWY-7286", "PWY-7285"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis"], "type": "Family"}, "IPR023994": {"description": "[NiFe]-hydrogenase assembly, chaperone, HybE", "go_ids": [], "go_terms": [], "name": "NiFe-hyd_HybE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023995": {"description": "Oxygen-independent coproporphyrinogen-III oxidase-like protein HemZ", "go_ids": [], "go_terms": [], "name": "HemZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023996": {"description": "TonB-dependent outer membrane protein, SusC/RagA", "go_ids": [], "go_terms": [], "name": "TonB-dep_OMP_SusC/RagA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023997": {"description": "TonB-dependent outer membrane protein SusC/RagA, conserved site", "go_ids": [], "go_terms": [], "name": "TonB-dep_OMP_SusC/RagA_CS", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR023998": {"description": "Ferric aerobactin reductase IutB-like", "go_ids": [], "go_terms": [], "name": "FCR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR023999": {"description": "Formate transporter FocA", "go_ids": ["GO:0015724", "GO:0015499", "GO:0016020"], "go_terms": ["GO:0015724:formate transport:P", "GO:0015499:formate transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "Formate_transptr_FocA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024000": {"description": "Conserved hypothetical protein CHP04046, FMN-dependent", "go_ids": [], "go_terms": [], "name": "CHP04046_FMN-dependent", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024001": {"description": "Cysteine-rich peptide, radical SAM maturase, CcpM", "go_ids": [], "go_terms": [], "name": "Cys-rich_pep_rSAM_mat_CcpM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024003": {"description": "Putative luciferase-like monooxygenase, KPN01858", "go_ids": [], "go_terms": [], "name": "Luciferase-like_KPN01858", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024004": {"description": "PEP-CTERM/XrtA system glycosyltransferase", "go_ids": [], "go_terms": [], "name": "PEP-CTERM/XrtA_GlycosylTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024005": {"description": "Colanic acid biosynthesis, acetyltransferase, WcaF", "go_ids": [], "go_terms": [], "name": "Colanic_acid_synth_WcaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024006": {"description": "Alternate signal-mediated exported protein, actinobacteria", "go_ids": [], "go_terms": [], "name": "Alt_signal_exp_actinobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024007": {"description": "[FeFe]-hydrogenase maturation HydG, radical SAM", "go_ids": [], "go_terms": [], "name": "FeFe-hyd_mat_HydG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024008": {"description": "BsaA-like SipW-dependent biofilm matrix protein", "go_ids": [], "go_terms": [], "name": "BsaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024009": {"description": "Colanic acid biosynthesis, glycosyl transferase, WcaA", "go_ids": [], "go_terms": [], "name": "Colanic_acid_synth_WcaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024010": {"description": "Colanic acid biosynthesis, glycosyl transferase, WcaE", "go_ids": [], "go_terms": [], "name": "Colanic_acid_synth_WcaE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024011": {"description": "Natural product biosynthesis luciferase-like monooxygenase domain", "go_ids": [], "go_terms": [], "name": "Biosynth_lucif-like_mOase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024012": {"description": "DNA phosphorothioation system restriction enzyme, putative", "go_ids": [], "go_terms": [], "name": "Dnd_restrict_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024013": {"description": "Putative colanic acid polymerase WcaD", "go_ids": [], "go_terms": [], "name": "WcaD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024014": {"description": "FMNH(2)-dependent dimethylsulfone monooxygenase SfnG", "go_ids": [], "go_terms": [], "name": "DMSO2_SphG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024015": {"description": "Pyridoxamine 5'-phosphate oxidase, probable FMN-dependent, Alr4036-like", "go_ids": [], "go_terms": [], "name": "Pyridox_Oxase_FMN-dep_Alr4036", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024016": {"description": "Conserved hypothetical protein CHP04064, radical SAM", "go_ids": [], "go_terms": [], "name": "CHP04064_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024017": {"description": "Petide cyclisation enzyme, radical SAM", "go_ids": [], "go_terms": [], "name": "Pep_cycl_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024018": {"description": "Conserved hypothetical protein CHP04083, radical SAM", "go_ids": [], "go_terms": [], "name": "CHP04083_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024019": {"description": "Conserved hypothetical protein CHP04096", "go_ids": [], "go_terms": [], "name": "CHP04096", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024020": {"description": "Anti sigma-R factor, mycothiol system,RsrA", "go_ids": [], "go_terms": [], "name": "Anit_sigma_mycothiol_RsrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024021": {"description": "[FeFe]-hydrogenase maturation HydE, radical SAM", "go_ids": [], "go_terms": [], "name": "FeFe-hyd_HydE_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024022": {"description": "Transcription regulator HTH, surface antigen", "go_ids": [], "go_terms": [], "name": "Tscrpt_reg_HTH_surface_antigen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024023": {"description": "His-Xaa-Ser system radical SAM maturase HxsB", "go_ids": [], "go_terms": [], "name": "rSAM_paired_HxsB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024024": {"description": "D-alanyl transfer protein DltB", "go_ids": ["GO:0016746", "GO:0070395"], "go_terms": ["GO:0016746:acyltransferase activity:F", "GO:0070395:lipoteichoic acid biosynthetic process:P"], "name": "DltB", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR024025": {"description": "SCIFF radical SAM maturase", "go_ids": [], "go_terms": [], "name": "SCIFF_rSAM_maturase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024026": {"description": "3'-RNA ribose 2'-O-methyltransferase, Hen1, bacterial", "go_ids": [], "go_terms": [], "name": "3'-RNA_MeTfrase_Hen1_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024027": {"description": "Colanic acid biosynthesis, acetyltransferase, WcaB", "go_ids": ["GO:0016747"], "go_terms": ["GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "Colanic_acid_synth_WcaB", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR024028": {"description": "Polynucleotide kinase-phosphatase, bacterial", "go_ids": [], "go_terms": [], "name": "PNKP_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024029": {"description": "Pyridoxamine 5-phosphate oxidase, FMN-dependent", "go_ids": [], "go_terms": [], "name": "Pyridox_Oxase_FMN-dep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024030": {"description": "AIR synthase-related protein, sll0787 family", "go_ids": [], "go_terms": [], "name": "AIR_synthase-rel_sll0787", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024031": {"description": "PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family", "go_ids": [], "go_terms": [], "name": "MSMEG_5819/OxyR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024032": {"description": "His-Xaa-Ser system radical SAM maturase HxsC", "go_ids": [], "go_terms": [], "name": "rSAM_paired_HxsC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024033": {"description": "Oxamate carbamoyltransferase subunit AllG, helical domain", "go_ids": [], "go_terms": [], "name": "OXTCase_su_AllG_h-dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024034": {"description": "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "ATPase_F1/V1_b/a_C", "pathway_ids": ["PWY-7980", "R-MMU-1222556", "R-CEL-1222556", "R-MMU-9837999", "R-HSA-2151201", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-CFA-1268020", "R-CEL-163210", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-CFA-8949613", "R-HSA-9639288", "R-DME-8949613", "R-PFA-917977", "R-HSA-1222556", "R-HSA-1268020", "R-SPO-917977", "R-BTA-77387", "R-MMU-1268020", "R-CEL-9639288", "R-SPO-1222556", "R-DDI-1222556", "R-HSA-9837999", "R-RNO-163210", "R-MMU-8949613", "R-CFA-9837999", "R-RNO-1268020", "R-DDI-9837999", "R-SCE-917977", "R-SCE-1222556", "R-MMU-77387", "R-BTA-1222556", "R-DDI-9639288", "R-SCE-77387", "R-CEL-9837999", "R-DDI-1268020", "R-DME-917977", "R-BTA-983712", "R-DME-9837999", "R-MMU-163210", "R-DME-77387", "R-DME-163210", "R-CEL-8949613", "R-RNO-9837999", "R-CFA-163210", "R-HSA-8949613", "R-HSA-163210", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-PFA-1222556", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-9837999", "R-SPO-77387", "R-SCE-9837999", "R-CEL-917977", "R-HSA-917977", "R-CEL-1268020", "R-RNO-8949613", "R-MMU-983712", "R-DDI-983712", "R-DME-1268020", "R-DDI-917977", "R-PFA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["PWY-7980:t:ATP biosynthesis", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-CFA-1268020:r:Mitochondrial protein import", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-CFA-8949613:r:Cristae formation", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DME-8949613:r:Cristae formation", "R-PFA-917977:r:Transferrin endocytosis and recycling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-BTA-77387:r:Insulin receptor recycling", "R-MMU-1268020:r:Mitochondrial protein import", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-8949613:r:Cristae formation", "R-CFA-9837999:r:Mitochondrial protein degradation", "R-RNO-1268020:r:Mitochondrial protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-MMU-77387:r:Insulin receptor recycling", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-SCE-77387:r:Insulin receptor recycling", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DDI-1268020:r:Mitochondrial protein import", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-77387:r:Insulin receptor recycling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-CFA-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-PFA-1222556:r:ROS and RNS production in phagocytes", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SPO-77387:r:Insulin receptor recycling", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-CEL-1268020:r:Mitochondrial protein import", "R-RNO-8949613:r:Cristae formation", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-DME-1268020:r:Mitochondrial protein import", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-PFA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR024035": {"description": "MSMEG_0567 GNAT N-acetyltransferase", "go_ids": [], "go_terms": [], "name": "MSMEG_0567_GNAT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024036": {"description": "tRNA-dihydrouridine synthase, putative, C-terminal", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "tRNA-dHydroUridine_Synthase_C", "pathway_ids": ["PWY-6309", "PWY-8382", "PWY-7655", "PWY-5292", "PWY-7096", "PWY-7300", "PWY-8374", "PWY-5956", "PWY-8103", "PWY-6302", "PWY-6996", "PWY-7881", "PWY-6824", "PWY-7154", "PWY-5367", "PWY-8152", "PWY-5984", "PWY-5393", "PWY-5972", "PWY-6944", "PWY-7770", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-6332", "PWY-7846", "PWY-6088", "PWY-7155", "PWY-8044", "PWY-6786", "PWY-7653", "PWY-2541", "PWY-5818", "PWY-7826"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-7096:t:triclosan resistance", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-6996:t:daidzin and daidzein degradation", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-6824:t:justicidin B biosynthesis", "PWY-7154:t:ergosterol biosynthesis II", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-5984:t:rifamycin B biosynthesis", "PWY-5393:t:raspberry ketone biosynthesis", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7770:t:indolmycin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-6332:t:coumestrol biosynthesis", "PWY-7846:t:heme degradation V", "PWY-6088:t:3-chlorobenzoate degradation I (via chlorocatechol)", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-7653:t:griseofulvin biosynthesis", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWY-5818:t:validamycin biosynthesis", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis"], "type": "Homologous_superfamily"}, "IPR024037": {"description": "Alternate ATP synthase, F1 complex, subunit epsilon", "go_ids": [], "go_terms": [], "name": "Alt_ATP_synth_F1_esu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024038": {"description": "MYXO-CTERM protein-sorting domain", "go_ids": [], "go_terms": [], "name": "MYXO-CTERM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024041": {"description": "Ammonium transporter AmtB-like domain", "go_ids": ["GO:0008519", "GO:0016020", "GO:0072488"], "go_terms": ["GO:0008519:ammonium channel activity:F", "GO:0016020:membrane:C", "GO:0072488:ammonium transmembrane transport:P"], "name": "NH4_transpt_AmtB-like_dom", "pathway_ids": ["R-RNO-444411", "R-MMU-1237044", "R-DDI-1247673", "R-HSA-5619042", "R-HSA-9037628", "R-HSA-1247673", "R-RNO-1237044", "R-RNO-1247673", "R-MMU-444411", "R-MMU-1247673", "R-BTA-444411", "R-HSA-1237044", "R-DDI-1237044", "R-HSA-444411", "R-DRE-444411", "R-DDI-444411", "R-GGA-444411", "R-CFA-1247673", "R-CFA-444411", "R-XTR-444411", "R-CFA-1237044"], "pathways": ["R-RNO-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DDI-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-5619042:r:Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)", "R-HSA-9037628:r:Rhesus blood group biosynthesis", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-MMU-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DDI-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-DRE-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-DDI-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-GGA-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-CFA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-CFA-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-XTR-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-CFA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen"], "type": "Domain"}, "IPR024042": {"description": "TM1646-like domain superfamily", "go_ids": [], "go_terms": [], "name": "TM1646-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024044": {"description": "NifT/FixU barrel-like domain superfamily", "go_ids": [], "go_terms": [], "name": "NifT/FixU_barrel-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024046": {"description": "Flagellar assembly factor FliW domain superfamily", "go_ids": [], "go_terms": [], "name": "Flagellar_assmbl_FliW_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024047": {"description": "MM3350-like superfamily", "go_ids": [], "go_terms": [], "name": "MM3350-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024048": {"description": "von Hippel-Lindau disease tumour suppressor, alpha domain", "go_ids": [], "go_terms": [], "name": "VHL_alpha_dom", "pathway_ids": ["R-HSA-3232142", "R-MMU-8951664", "R-RNO-1234176", "R-MMU-3232142", "R-HSA-9694686", "R-HSA-9706019", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-RNO-3232142", "R-RNO-9706019", "R-HSA-9682706", "R-MMU-9706019", "R-HSA-983168", "R-RNO-983168", "R-MMU-1234176", "R-HSA-1234176"], "pathways": ["R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-8951664:r:Neddylation", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Domain"}, "IPR024049": {"description": "eRF1, domain 1", "go_ids": [], "go_terms": [], "name": "eRF1_1_sf", "pathway_ids": ["R-RNO-9629569", "R-DDI-975956", "R-BTA-975957", "R-CEL-975957", "R-SPO-72764", "R-HSA-9010553", "R-CEL-9629569", "R-XTR-975956", "R-SPO-975957", "R-CEL-72764", "R-HSA-975956", "R-XTR-975957", "R-CEL-975956", "R-DME-72764", "R-SCE-975957", "R-BTA-72764", "R-SCE-72764", "R-MMU-975956", "R-HSA-9629569", "R-RNO-975957", "R-MMU-72764", "R-SPO-975956", "R-DME-975956", "R-SCE-975956", "R-SPO-9629569", "R-MMU-975957", "R-DME-9629569", "R-DDI-72764", "R-HSA-72764", "R-HSA-975957", "R-MMU-9629569", "R-XTR-72764", "R-RNO-975956", "R-BTA-975956", "R-DDI-975957", "R-XTR-9629569", "R-BTA-9629569", "R-DME-975957"], "pathways": ["R-RNO-9629569:r:Protein hydroxylation", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72764:r:Eukaryotic Translation Termination", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-9629569:r:Protein hydroxylation", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-72764:r:Eukaryotic Translation Termination", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-72764:r:Eukaryotic Translation Termination", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-72764:r:Eukaryotic Translation Termination", "R-SCE-72764:r:Eukaryotic Translation Termination", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9629569:r:Protein hydroxylation", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72764:r:Eukaryotic Translation Termination", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-9629569:r:Protein hydroxylation", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9629569:r:Protein hydroxylation", "R-DDI-72764:r:Eukaryotic Translation Termination", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9629569:r:Protein hydroxylation", "R-XTR-72764:r:Eukaryotic Translation Termination", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Homologous_superfamily"}, "IPR024050": {"description": "AICAR transformylase, insert domain superfamily", "go_ids": [], "go_terms": [], "name": "AICAR_Tfase_insert_dom_sf", "pathway_ids": ["PWY-6123", "PWY-7234", "PWY-6124", "R-SPO-73817", "R-RNO-73817", "R-SCE-73817", "R-BTA-73817", "R-HSA-73817", "R-MMU-73817", "R-HSA-9725370", "R-GGA-419140"], "pathways": ["PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-7234:t:inosine-5'-phosphate biosynthesis III", "PWY-6124:t:inosine-5'-phosphate biosynthesis II", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Homologous_superfamily"}, "IPR024051": {"description": "AICAR transformylase, duplicated domain superfamily", "go_ids": [], "go_terms": [], "name": "AICAR_Tfase_dup_dom_sf", "pathway_ids": ["PWY-6123", "PWY-7234", "PWY-6124", "R-SPO-73817", "R-DDI-73817", "R-RNO-73817", "R-SCE-73817", "R-BTA-73817", "R-HSA-73817", "R-MMU-73817", "R-HSA-9725370", "R-GGA-419140"], "pathways": ["PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-7234:t:inosine-5'-phosphate biosynthesis III", "PWY-6124:t:inosine-5'-phosphate biosynthesis II", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Homologous_superfamily"}, "IPR024052": {"description": "Phosphopentomutase DeoB cap domain superfamily", "go_ids": ["GO:0008973"], "go_terms": ["GO:0008973:phosphopentomutase activity:F"], "name": "Phosphopentomutase_DeoB_cap_sf", "pathway_ids": ["PWY-7180"], "pathways": ["PWY-7180:t:2-deoxy-alpha-D-ribose 1-phosphate degradation"], "type": "Homologous_superfamily"}, "IPR024053": {"description": "von Hippel-Lindau disease tumour suppressor, beta domain", "go_ids": [], "go_terms": [], "name": "VHL_beta_dom", "pathway_ids": ["R-RNO-1234176", "R-DME-983168", "R-MMU-3232142", "R-HSA-9694686", "R-HSA-9706019", "R-HSA-8951664", "R-DME-8951664", "R-RNO-9706019", "R-HSA-9682706", "R-MMU-9706019", "R-HSA-983168", "R-CEL-983168", "R-MMU-1234176", "R-HSA-3232142", "R-MMU-8951664", "R-CEL-1234176", "R-CEL-3232142", "R-RNO-8951664", "R-MMU-983168", "R-RNO-3232142", "R-DME-1234176", "R-RNO-983168", "R-CEL-8951664", "R-HSA-1234176"], "pathways": ["R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-8951664:r:Neddylation", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Domain"}, "IPR024054": {"description": "Translation initiation factor 2, alpha subunit, middle domain superfamily", "go_ids": [], "go_terms": [], 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"R-PFA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-DME-382556:r:ABC-family proteins mediated transport", "R-DME-72649:r:Translation initiation complex formation", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-PFA-9840373:r:Cellular response to mitochondrial stress", "R-DME-381042:r:PERK regulates gene expression", "R-MMU-72649:r:Translation initiation complex formation", "R-PFA-72731:r:Recycling of eIF2:GDP", 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"R-SCE-72731:r:Recycling of eIF2:GDP", "R-XTR-9840373:r:Cellular response to mitochondrial stress", "R-PFA-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-381042:r:PERK regulates gene expression", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-GGA-72731:r:Recycling of eIF2:GDP", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72731:r:Recycling of eIF2:GDP", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-381042:r:PERK regulates gene expression", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9840373:r:Cellular response to mitochondrial stress", "R-RNO-72649:r:Translation initiation complex formation", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-GGA-72649:r:Translation initiation complex formation", "R-DDI-9840373:r:Cellular response to mitochondrial stress", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-381042:r:PERK regulates gene expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-GGA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-PFA-381042:r:PERK regulates gene expression", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-PFA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-DME-382556:r:ABC-family proteins mediated transport", "R-DME-72649:r:Translation initiation complex formation", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-PFA-9840373:r:Cellular response to mitochondrial stress", "R-DME-381042:r:PERK regulates gene expression", "R-MMU-72649:r:Translation initiation complex formation", "R-PFA-72731:r:Recycling of eIF2:GDP", "R-PFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-XTR-381042:r:PERK regulates gene expression", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-9840373:r:Cellular response to mitochondrial stress", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72649:r:Translation initiation complex formation", "R-GGA-9840373:r:Cellular response to mitochondrial stress", "R-XTR-382556:r:ABC-family proteins mediated transport", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR024056": {"description": "Apical membrane antigen 1 domain superfamily", "go_ids": [], "go_terms": [], "name": "Apmem_Ag1_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024057": {"description": "Nucleoplasmin core domain", "go_ids": [], "go_terms": [], "name": "Nucleoplasmin_core_dom", "pathway_ids": ["R-HSA-606279", "R-HSA-9821993", "R-HSA-6804115", "R-HSA-9700645", "R-HSA-9833482", "R-MMU-3899300", "R-RNO-606279", "R-MMU-606279", "R-MMU-8869496", "R-RNO-6804115", "R-DME-9833482", "R-MMU-9833482", "R-HSA-9725371", "R-HSA-8869496", "R-RNO-8869496", "R-DME-3899300", "R-MMU-6804115", "R-HSA-3899300", "R-HSA-180746", "R-HSA-9692914", "R-HSA-9725370", "R-RNO-9833482", "R-DME-8869496", "R-RNO-3899300"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DME-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-180746:r:Nuclear import of Rev protein", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-3899300:r:SUMOylation of transcription cofactors"], "type": "Domain"}, "IPR024058": {"description": "Cytochrome f transmembrane anchor", "go_ids": [], "go_terms": [], "name": "Cyt-f_TM", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024059": {"description": "YopX-like, N-terminal", "go_ids": [], "go_terms": [], "name": "YopX-like_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024060": {"description": "Ureidoglycolate lyase domain superfamily", "go_ids": ["GO:0050385"], "go_terms": ["GO:0050385:ureidoglycolate lyase activity:F"], "name": "Ureidoglycolate_lyase_dom_sf", "pathway_ids": ["PWY-5705", "PWY-5694"], "pathways": ["PWY-5705:t:allantoin degradation to glyoxylate III", "PWY-5694:t:allantoin degradation to glyoxylate I"], "type": "Homologous_superfamily"}, "IPR024061": {"description": "NDT80, DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "NDT80_DNA-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024062": {"description": "Bacteriophage PBS2, uracil-glycosylase inhibitor", "go_ids": [], "go_terms": [], "name": "Phage_PBS2_Ugi", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024064": {"description": "FdhE-like superfamily", "go_ids": [], "go_terms": [], "name": "FdhE-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024065": {"description": "DNA topoisomerase V, catalytic domain superfamily", "go_ids": [], "go_terms": [], "name": "TopoV_catalytic_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024066": {"description": "RGS, subdomain 1/3", "go_ids": [], "go_terms": [], "name": "RGS_subdom1/3", "pathway_ids": ["R-RNO-201681", "R-MMU-416476", "R-HSA-5358751", "R-HSA-201681", "R-DME-209155", "R-HSA-8939256", "R-RNO-4641262", "R-DRE-195253", "R-DME-432553", "R-HSA-5689880", "R-RNO-418597", "R-HSA-5467348", "R-MMU-418597", "R-HSA-416476", "R-DRE-4641257", "R-MMU-418594", "R-HSA-196299", "R-CEL-416476", "R-RNO-418594", "R-DME-195253", "R-DME-209214", "R-MMU-5689880", "R-BTA-418594", "R-RNO-4641257", "R-HSA-5358747", "R-RNO-196299", "R-DRE-4641262", "R-DME-209396", "R-DME-4641262", "R-HSA-5339716", "R-HSA-5467337", "R-HSA-4641257", "R-HSA-4641262", "R-RNO-416476", "R-HSA-9018519", "R-MMU-195253", "R-DME-209413", "R-HSA-195253", "R-HSA-5358752", "R-DME-209190", "R-HSA-5358749", "R-HSA-8931987", "R-MMU-196299", "R-DME-4641257", "R-DME-209360", "R-DME-209461", "R-DME-418594", "R-MMU-201681", "R-DME-196299", "R-CEL-418594", "R-SSC-416476", "R-BTA-418597", "R-HSA-5467340", "R-RNO-5689880", "R-BTA-416476", "R-DRE-196299", "R-HSA-418594", "R-DME-209440", "R-MMU-4641257", "R-CEL-418597", "R-HSA-418597", "R-SSC-418597", "R-MMU-4641262", "R-SSC-418594", "R-HSA-4411364", "R-RNO-195253"], "pathways": ["R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-418597:r:G alpha (z) signalling events", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-MMU-418597:r:G alpha (z) signalling events", "R-HSA-416476:r:G alpha (q) signalling events", "R-DRE-4641257:r:Degradation of AXIN", "R-MMU-418594:r:G alpha (i) signalling events", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-416476:r:G alpha (q) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-209214:r:Phosphorylation of SMO", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-418594:r:G alpha (i) signalling events", "R-RNO-4641257:r:Degradation of AXIN", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-209396:r:Phosphorylation of ARM", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-DME-209190:r:Phosphorylation of CI", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-DME-4641257:r:Degradation of AXIN", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DME-418594:r:G alpha (i) signalling events", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-418594:r:G alpha (i) signalling events", "R-SSC-416476:r:G alpha (q) signalling events", "R-BTA-418597:r:G alpha (z) signalling events", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-5689880:r:Ub-specific processing proteases", "R-BTA-416476:r:G alpha (q) signalling events", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-418594:r:G alpha (i) signalling events", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-MMU-4641257:r:Degradation of AXIN", "R-CEL-418597:r:G alpha (z) signalling events", "R-HSA-418597:r:G alpha (z) signalling events", "R-SSC-418597:r:G alpha (z) signalling events", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SSC-418594:r:G alpha (i) signalling events", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Homologous_superfamily"}, "IPR024067": {"description": "Methylmalonyl-CoA mutase small subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "Me-malonyl-CoA_mutase_sm_su_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024068": {"description": "Rotavirus NSP2, N-terminal", "go_ids": ["GO:0016817"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F"], "name": "Rotavirus_NSP2_N", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Homologous_superfamily"}, "IPR024069": {"description": "AF2212-like domain superfamily", "go_ids": [], "go_terms": [], "name": "AF2212-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024071": {"description": "S-Me-THD, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "S-Me-THD_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024072": {"description": "Dihydrofolate reductase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "DHFR-like_dom_sf", "pathway_ids": ["PWY-6614", "PWY-3841", "R-DME-196757", "R-HSA-69205", "R-HSA-1474151", "R-MMU-196757", "R-RNO-196757", "R-SCE-196757", "R-SPO-196757", "R-HSA-196757", "R-CEL-196757"], "pathways": ["PWY-6614:t:tetrahydrofolate biosynthesis I", "PWY-3841:t:folate transformations II (plants)", "R-DME-196757:r:Metabolism of folate and pterines", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-196757:r:Metabolism of folate and pterines", "R-RNO-196757:r:Metabolism of folate and pterines", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Homologous_superfamily"}, "IPR024073": {"description": "Argininosuccinate synthetase mutimerisation domain, C-terminal tail", "go_ids": ["GO:0042803"], "go_terms": ["GO:0042803:protein homodimerization activity:F"], "name": "AS_multimer_C_tail", "pathway_ids": ["PWY-7400", "PWY-4984", "PWY-5", "PWY-4983", "PWY-5154"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-4984:t:urea cycle", "PWY-5:t:canavanine biosynthesis", "PWY-4983:t:nitric oxide biosynthesis II (mammals)", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Homologous_superfamily"}, "IPR024074": {"description": "Argininosuccinate synthetase, catalytic/multimerisation domain body", "go_ids": ["GO:0004055"], "go_terms": ["GO:0004055:argininosuccinate synthase 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"Homologous_superfamily"}, "IPR024076": {"description": "Rotavirus NSP2, C-terminal", "go_ids": ["GO:0016817"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F"], "name": "Rotavirus_NSP2_C", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Homologous_superfamily"}, "IPR024077": {"description": "Neurolysin/Thimet oligopeptidase, domain 2", "go_ids": [], "go_terms": [], "name": "Neurolysin/TOP_dom2", "pathway_ids": ["R-DDI-983168", "R-SSC-375276", "R-RNO-375276", "R-HSA-375276", "R-MMU-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-375276"], "pathways": ["R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-375276:r:Peptide ligand-binding receptors"], "type": "Homologous_superfamily"}, "IPR024078": {"description": "Putative deacetylase LmbE-like domain superfamily", "go_ids": [], "go_terms": [], "name": "LmbE-like_dom_sf", "pathway_ids": ["R-SPO-162710", "R-HSA-162710", "R-RNO-162710", "R-SCE-162710", "R-MMU-162710", "R-MTU-879325", "R-BTA-162710", "R-MTU-879235", "R-MTU-879299", "R-DDI-162710"], "pathways": ["R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MTU-879325:r:Mycothiol catabolism", "R-BTA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MTU-879235:r:Mycothiol-dependent detoxification", "R-MTU-879299:r:Mycothiol biosynthesis", "R-DDI-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Homologous_superfamily"}, "IPR024079": {"description": "Metallopeptidase, catalytic domain superfamily", "go_ids": ["GO:0008237"], "go_terms": ["GO:0008237:metallopeptidase activity:F"], "name": "MetalloPept_cat_dom_sf", "pathway_ids": ["R-CEL-1592389", "R-HSA-2243919", "R-RNO-2022090", "R-MMU-210991", "R-MMU-3928665", "R-RNO-1474228", "R-RNO-9009391", "R-MMU-9009391", "R-RNO-193692", "R-BTA-8957275", "R-HSA-2979096", "R-GGA-9009391", "R-DRE-1650814", "R-HSA-9013507", "R-HSA-2691232", "R-HSA-210991", "R-HSA-1474228", "R-MMU-2534343", "R-MMU-5578768", "R-SSC-381426", "R-SSC-1592389", "R-MMU-1592389", "R-CEL-2214320", "R-BTA-1474228", "R-RNO-9839383", "R-DME-1592389", "R-GGA-1442490", "R-HSA-2022377", "R-HSA-8941332", "R-RNO-5173214", "R-SSC-375276", "R-HSA-2022090", "R-HSA-2660826", "R-MMU-5173214", "R-MMU-5682910", "R-HSA-9762292", "R-HSA-2644606", "R-CEL-5173214", "R-RNO-6798695", "R-BTA-375276", "R-MMU-9839383", "R-SSC-6798695", "R-HSA-375276", "R-HSA-9662834", "R-GGA-1474228", "R-HSA-1251985", "R-DME-2022377", "R-CEL-2179392", "R-MMU-193692", "R-HSA-9013700", "R-MMU-9013507", "R-SSC-1442490", "R-GGA-1592389", "R-HSA-1442490", "R-BTA-1433557", "R-BTA-1650814", "R-RNO-8941237", "R-CFA-1592389", "R-RNO-1592389", "R-SSC-8957275", "R-DME-6798695", "R-DME-2179392", "R-RNO-2022377", "R-DME-2022090", "R-BTA-9009391", "R-DME-2243919", "R-CEL-3928665", "R-DME-1474228", "R-MMU-2022090", "R-HSA-9009391", "R-HSA-5173214", "R-MMU-1650814", "R-HSA-3928665", "R-GGA-3928665", "R-DME-1442490", "R-CEL-1442490", "R-HSA-5682910", "R-HSA-9856530", "R-BTA-3928665", "R-HSA-6798695", "R-CEL-6798695", "R-BTA-6798695", "R-HSA-2179392", "R-CFA-1442490", "R-HSA-75893", "R-SSC-1474228", "R-MMU-375276", "R-MMU-8957275", "R-MMU-2243919", "R-HSA-1650814", "R-MMU-2214320", "R-DME-2214320", "R-RNO-2179392", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-RNO-3928665", "R-HSA-177929", "R-DME-3928665", "R-HSA-5210891", "R-HSA-381426", "R-MMU-1474228", "R-MMU-2022377", "R-MMU-75893", "R-MMU-1433557", "R-DME-1650814", "R-RNO-5578768", "R-HSA-9845619", "R-RNO-9013507", "R-DME-5578768", "R-HSA-6785807", "R-MMU-9762292", "R-HSA-982772", "R-RNO-381426", "R-RNO-1433557", "R-HSA-75892", "R-BTA-1592389", "R-CFA-1474228", "R-HSA-8941237", "R-MMU-6798695", "R-RNO-983168", "R-HSA-193692", "R-CEL-1650814", "R-SPO-6798695", "R-MMU-2179392", "R-HSA-2122948", "R-DRE-2243919", "R-BTA-1442490", "R-HSA-977225", "R-BTA-5173214", "R-HSA-9845621", "R-SPO-8941237", "R-HSA-5578768", "R-CFA-2022090", "R-CEL-1474228", "R-HSA-5362798", "R-MMU-8941237", "R-RNO-8957275", "R-BTA-381426", "R-RNO-75893", "R-SCE-983168", "R-HSA-9918481", "R-CFA-2179392", "R-HSA-2214320", "R-HSA-8963896", "R-CEL-210991", "R-HSA-5083635", "R-HSA-2894862", "R-HSA-9927432", "R-CFA-9009391", "R-HSA-9839383", "R-HSA-1592389", "R-HSA-983168", "R-HSA-1433557", "R-RNO-1442490", "R-DDI-983168", "R-MMU-8963896", "R-HSA-2534343", "R-RNO-375276", "R-MMU-983168", "R-HSA-8957275", "R-MMU-1442490"], "pathways": ["R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-210991:r:Basigin interactions", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-GGA-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-210991:r:Basigin interactions", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-MMU-5578768:r:Physiological factors", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-CEL-2214320:r:Anchoring fibril formation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-GGA-1442490:r:Collagen degradation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-9762292:r:Regulation of CDH11 function", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-CEL-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-SSC-1442490:r:Collagen degradation", "R-GGA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-8941237:r:Invadopodia formation", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-2243919:r:Crosslinking of collagen fibrils", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1442490:r:Collagen degradation", "R-CEL-1442490:r:Collagen degradation", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-1442490:r:Collagen degradation", "R-HSA-75893:r:TNF signaling", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2214320:r:Anchoring fibril formation", "R-DME-2214320:r:Anchoring fibril formation", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177929:r:Signaling by EGFR", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-75893:r:TNF signaling", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-5578768:r:Physiological factors", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-5578768:r:Physiological factors", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8941237:r:Invadopodia formation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DRE-2243919:r:Crosslinking of collagen fibrils", "R-BTA-1442490:r:Collagen degradation", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-SPO-8941237:r:Invadopodia formation", "R-HSA-5578768:r:Physiological factors", "R-CFA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-MMU-8941237:r:Invadopodia formation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-75893:r:TNF signaling", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CFA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8963896:r:HDL assembly", "R-CEL-210991:r:Basigin interactions", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-1442490:r:Collagen degradation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8963896:r:HDL assembly", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1442490:r:Collagen degradation"], "type": "Homologous_superfamily"}, "IPR024080": {"description": "Neurolysin/Thimet oligopeptidase, N-terminal", "go_ids": [], "go_terms": [], "name": "Neurolysin/TOP_N", "pathway_ids": ["R-DDI-983168", "R-SSC-375276", "R-RNO-375276", "R-HSA-375276", "R-MMU-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-375276"], "pathways": ["R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-375276:r:Peptide ligand-binding receptors"], "type": "Homologous_superfamily"}, "IPR024082": {"description": "Proline dehydrogenase PutA, domain II", "go_ids": ["GO:0003842"], "go_terms": ["GO:0003842:L-glutamate gamma-semialdehyde dehydrogenase activity:F"], "name": "PRODH_PutA_dom_II", "pathway_ids": ["PWY-6922", "PWY-5737", "PWY-6853"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-5737:t:(5R)-carbapenem carboxylate biosynthesis", "PWY-6853:t:ethene biosynthesis II (microbes)"], "type": "Domain"}, "IPR024083": {"description": "Fumarase/histidase, N-terminal", "go_ids": [], "go_terms": [], "name": "Fumarase/histidase_N", "pathway_ids": ["R-DDI-9837999", "R-RNO-70921", "R-SPO-70635", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-70921", "R-DDI-70921", "R-HSA-70635", "R-CEL-70921", "R-RNO-9837999", "R-RNO-70635", "R-DRE-71403", "R-DRE-9837999", "R-MMU-70635", "R-SPO-71403", "R-CEL-71403", "R-GGA-187630", "R-SPO-9837999", "R-MMU-71403", "R-SCE-71403", "R-HSA-9956529", "R-SCE-9837999", "R-HSA-70921", "R-MMU-70921", "R-BTA-70635", "R-HSA-9837999", "R-DDI-71403", "R-RNO-71403", "R-SCE-70635", "R-HSA-71403"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-70921:r:Histidine catabolism", "R-SPO-70635:r:Urea cycle", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism", "R-HSA-70635:r:Urea cycle", "R-CEL-70921:r:Histidine catabolism", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-70635:r:Urea cycle", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-MMU-70635:r:Urea cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-GGA-187630:r:Arginine metabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9956529:r:ASL variants cause argininosuccinate aciduria", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-70921:r:Histidine catabolism", "R-MMU-70921:r:Histidine catabolism", "R-BTA-70635:r:Urea cycle", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-70635:r:Urea cycle", "R-HSA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Homologous_superfamily"}, "IPR024084": {"description": "Isopropylmalate dehydrogenase-like domain", "go_ids": [], "go_terms": [], "name": "IsoPropMal-DH-like_dom", "pathway_ids": ["PWY-7396", "R-HSA-6798695", "R-SPO-6798695", "R-MMU-9837999", "R-HSA-2151201", "R-SCE-6798695", "R-HSA-2978092", "R-SPO-389542", "R-DDI-389542", "R-RNO-9033241", "R-HSA-9818025", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-HSA-1268020", "R-MMU-71403", "R-BTA-9837999", "R-HSA-389542", "R-SCE-9033241", "R-HSA-9837999", "R-DDI-71403", "R-RNO-71403", "R-DDI-9033241", "R-HSA-71403", "R-DDI-6798695", "R-HSA-9854311", "R-CEL-9837999", "R-BTA-9854311", "R-SCE-389542", "R-BTA-71403", "R-DME-9837999", "R-MMU-389542", "R-MMU-9033241", "R-RNO-9837999", "R-RNO-389542", "R-MMU-2151201", "R-SPO-9033241", "R-RNO-9854311", "R-BTA-2151201", "R-SCE-71403", "R-RNO-2151201", "R-MMU-6798695", "R-DME-71403", "R-HSA-9033241", "R-RNO-6798695"], "pathways": ["PWY-7396:t:butanol and isobutanol biosynthesis (engineered)", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2978092:r:Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate", "R-SPO-389542:r:NADPH regeneration", "R-DDI-389542:r:NADPH regeneration", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-9818025:r:NFE2L2 regulating TCA cycle genes", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-389542:r:NADPH regeneration", "R-SCE-9033241:r:Peroxisomal protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SCE-389542:r:NADPH regeneration", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-389542:r:NADPH regeneration", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-389542:r:NADPH regeneration", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-9033241:r:Peroxisomal protein import", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR024086": {"description": "Phosphoglucosamine mutase, archaeal type", "go_ids": ["GO:0008966"], "go_terms": ["GO:0008966:phosphoglucosamine mutase activity:F"], "name": "GlmM_arc-type", "pathway_ids": ["PWY-6749"], "pathways": ["PWY-6749:t:CMP-legionaminate biosynthesis I"], "type": "Family"}, "IPR024087": {"description": "Creatininase-like superfamily", "go_ids": [], "go_terms": [], "name": "Creatininase-like_sf", "pathway_ids": ["PWY-6167"], "pathways": ["PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Homologous_superfamily"}, "IPR024088": {"description": "Tyrosine-tRNA ligase, bacterial-type", "go_ids": ["GO:0004831"], "go_terms": ["GO:0004831:tyrosine-tRNA ligase activity:F"], "name": "Tyr-tRNA-ligase_bac-type", "pathway_ids": ["R-HSA-379726"], "pathways": ["R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Family"}, "IPR024089": {"description": "Proline dehydrogenase PutA, domain I/II", "go_ids": ["GO:0003842"], "go_terms": ["GO:0003842:L-glutamate gamma-semialdehyde dehydrogenase activity:F"], "name": "PRODH_PutA_dom_I/II", "pathway_ids": ["PWY-6922", "PWY-5737", "PWY-6853"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-5737:t:(5R)-carbapenem carboxylate biosynthesis", "PWY-6853:t:ethene biosynthesis II (microbes)"], "type": "Homologous_superfamily"}, "IPR024090": {"description": "Proline dehydrogenase PutA, domain I", "go_ids": ["GO:0003842"], "go_terms": ["GO:0003842:L-glutamate gamma-semialdehyde dehydrogenase activity:F"], "name": "PRODH_PutA_dom_I", "pathway_ids": ["PWY-6922", "PWY-5737", "PWY-6853"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-5737:t:(5R)-carbapenem carboxylate biosynthesis", "PWY-6853:t:ethene biosynthesis II (microbes)"], "type": "Homologous_superfamily"}, "IPR024091": {"description": "LnmK-like bifunctional acyltransferase/decarboxylase domain", "go_ids": [], "go_terms": [], "name": "LnmK-like_bifun_acyl/decarbox", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024093": {"description": "Uncharacterised protein family MTH865", "go_ids": [], "go_terms": [], "name": "Uncharacterised_MTH865", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024094": {"description": "Cytochrome f large domain", "go_ids": [], "go_terms": [], "name": "Cyt_f_lg_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024095": {"description": "Vesicle tethering protein p115", "go_ids": ["GO:0048193"], "go_terms": ["GO:0048193:Golgi vesicle transport:P"], "name": "Vesicle_P115", "pathway_ids": ["R-HSA-204005", "R-SPO-6807878", "R-BTA-6807878", "R-MMU-204005", "R-SCE-6807878", "R-RNO-6807878", "R-DME-204005", "R-HSA-6807878", "R-BTA-204005", "R-MMU-6807878", "R-DME-6807878", "R-RNO-204005", "R-HSA-162658"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization"], "type": "Family"}, "IPR024096": {"description": "NO signalling/Golgi transport ligand-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "NO_sig/Golgi_transp_ligand-bd", "pathway_ids": ["R-MMU-204005", "R-DDI-204005", "R-HSA-445355", "R-HSA-392154", "R-DRE-204005", "R-PFA-204005", "R-SCE-204005", "R-SPO-204005", "R-RNO-8876198", "R-HSA-8876198", "R-MMU-445355", "R-DME-445355", "R-SCE-8876198", "R-RNO-204005", "R-DRE-8876198", "R-HSA-204005", "R-BTA-445355", "R-MMU-8876198", "R-RNO-445355", "R-CEL-8876198", "R-DDI-8876198", "R-PFA-8876198", "R-CEL-204005", "R-BTA-204005", "R-GGA-204005", "R-SPO-8876198"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-PFA-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-BTA-445355:r:Smooth Muscle Contraction", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-445355:r:Smooth Muscle Contraction", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-PFA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-GGA-204005:r:COPII-mediated vesicle transport", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Homologous_superfamily"}, "IPR024097": {"description": "Basic helix-loop-helix leucine zipper transcription factor", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "bHLH_ZIP_TF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024104": {"description": "Pseudokinase tribbles family/serine-threonine-protein kinase 40", "go_ids": [], "go_terms": [], "name": "Tribbles/Ser_Thr_kinase_40", "pathway_ids": ["R-HSA-165158", "R-HSA-1989781", "R-RNO-165158", "R-MMU-5218920", "R-RNO-1257604", "R-MMU-1257604", "R-DME-389357", "R-RNO-5218920", "R-BTA-165158", "R-DME-5218920", "R-HSA-9648895", "R-MMU-389357", "R-DME-165158", "R-HSA-5218920", "R-CEL-1257604", "R-CEL-389357", "R-DME-199418", "R-HSA-199418", "R-DME-1257604", "R-MMU-165158", "R-HSA-389357", "R-MMU-199418", "R-HSA-9031628", "R-HSA-1257604", "R-RNO-389357", "R-CEL-199418", "R-CEL-165158", "R-CEL-5218920", "R-HSA-9633012", "R-RNO-199418"], "pathways": ["R-HSA-165158:r:Activation of AKT2", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-165158:r:Activation of AKT2", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-165158:r:Activation of AKT2", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-165158:r:Activation of AKT2", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-MMU-165158:r:Activation of AKT2", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-199418:r:Negative regulation of the PI3K/AKT network", "R-CEL-165158:r:Activation of AKT2", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network"], "type": "Family"}, "IPR024110": {"description": "Immunoglobulin J chain", "go_ids": [], "go_terms": [], "name": "Ig_J", "pathway_ids": ["R-HSA-2168880", "R-MMU-2168880", "R-MMU-202733", "R-HSA-202733"], "pathways": ["R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR024111": {"description": "PEX5/PEX5L", "go_ids": [], "go_terms": [], "name": "PEX5/PEX5L", "pathway_ids": ["R-MMU-8866654", "R-RNO-9664873", "R-BTA-9664873", "R-MMU-9033241", "R-SPO-9664873", "R-RNO-8866654", "R-MMU-9664873", "R-HSA-8866654", "R-BTA-9033241", "R-RNO-9033241", "R-SPO-9033241", "R-DDI-9664873", "R-BTA-8866654", "R-SCE-9033241", "R-SCE-9664873", "R-DDI-9033241", "R-HSA-9033241", "R-DDI-8866654", "R-HSA-9664873"], "pathways": ["R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-9664873:r:Pexophagy", "R-BTA-9664873:r:Pexophagy", "R-MMU-9033241:r:Peroxisomal protein import", "R-SPO-9664873:r:Pexophagy", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-9664873:r:Pexophagy", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-DDI-9664873:r:Pexophagy", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-9033241:r:Peroxisomal protein import", "R-SCE-9664873:r:Pexophagy", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9664873:r:Pexophagy"], "type": "Family"}, "IPR024114": {"description": "Islet cell autoantigen 1/Ica1-like", "go_ids": [], "go_terms": [], "name": "Islet_autoAg_Ica1/Ica1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024119": {"description": "Transcription factor DEAF-1", "go_ids": [], "go_terms": [], "name": "TF_DEAF-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024128": {"description": "T-cell surface glycoprotein CD3 zeta subunit", "go_ids": [], "go_terms": [], "name": "T-cell_CD3_zeta", "pathway_ids": ["R-MMU-389948", "R-MMU-202433", "R-HSA-202433", "R-HSA-2029485", "R-HSA-2029482", "R-HSA-2029481", "R-MMU-202430", "R-HSA-202427", "R-MMU-198933", "R-HSA-202424", "R-HSA-164944", "R-HSA-198933", "R-MMU-202427", "R-HSA-202430", "R-HSA-9664422", "R-HSA-389948", "R-HSA-9664323", "R-MMU-202424"], "pathways": ["R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-202433:r:Generation of second messenger molecules", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-2029481:r:FCGR activation", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-164944:r:Nef and signal transduction", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-MMU-202424:r:Downstream TCR signaling"], "type": "Family"}, "IPR024129": {"description": "Sphingomyelin phosphodiesterase 4", "go_ids": ["GO:0050290"], "go_terms": ["GO:0050290:sphingomyelin phosphodiesterase D activity:F"], "name": "Sphingomy_SMPD4", "pathway_ids": ["PWY-7277", "R-DRE-9840310", "R-MMU-9840310", "R-HSA-9840310"], "pathways": ["PWY-7277:t:sphingolipid biosynthesis (mammals)", "R-DRE-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Family"}, "IPR024130": {"description": "DAP1/DAPL1", "go_ids": [], "go_terms": [], "name": "DAP1/DAPL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024131": {"description": "Peptide arginase FlmR/OhkR-like", "go_ids": [], "go_terms": [], "name": "FlmR/OhkR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024132": {"description": "Akirin", "go_ids": [], "go_terms": [], "name": "Akirin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024133": {"description": "Transmembrane protein 138", "go_ids": [], "go_terms": [], "name": "TM_138", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024134": {"description": "Superoxide dismutase (Cu/Zn)/superoxide dismutase copper chaperone", "go_ids": ["GO:0005507"], "go_terms": ["GO:0005507:copper ion binding:F"], "name": "SOD_Cu/Zn/SOD-chaperone", "pathway_ids": ["PWY-6854", "R-HSA-9818027", "R-HSA-3299685", "R-DRE-114608", "R-DRE-3299685", "R-DME-114608", "R-SSC-114608", "R-CEL-114608", "R-HSA-8950505", "R-SCE-114608", "R-SSC-3299685", "R-CEL-3299685", "R-DDI-114608", "R-MMU-3299685", "R-RNO-3299685", "R-SPO-114608", "R-RNO-114608", "R-DDI-3299685", "R-HSA-114608", "R-BTA-114608", "R-SCE-3299685", "R-BTA-3299685", "R-SPO-3299685", "R-DME-3299685", "R-XTR-114608", "R-HSA-1222387", "R-XTR-3299685", "R-MMU-114608"], "pathways": ["PWY-6854:t:ethene biosynthesis III (microbes)", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-DRE-114608:r:Platelet degranulation", "R-DRE-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-114608:r:Platelet degranulation", "R-SSC-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-SCE-114608:r:Platelet degranulation", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-114608:r:Platelet degranulation", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-XTR-114608:r:Platelet degranulation", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages", "R-XTR-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR024135": {"description": "Ragulator complex protein LAMTOR5", "go_ids": ["GO:0005737", "GO:0071986", "GO:0043066"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0071986:Ragulator complex:C", "GO:0043066:negative regulation of apoptotic process:P"], "name": "LAMTOR5", "pathway_ids": ["R-DDI-9639288", "R-DDI-5628897", "R-DDI-1632852", "R-DDI-165159", "R-BTA-166208", "R-MMU-380972", "R-MMU-165159", "R-MMU-1632852", "R-DDI-166208", "R-MMU-9639288", "R-BTA-165159", "R-BTA-9639288", "R-DDI-380972", "R-HSA-9639288", "R-HSA-5628897", "R-BTA-380972", "R-BTA-5628897", "R-BTA-1632852", "R-XTR-165159", "R-MMU-8943724", "R-DDI-8943724", "R-HSA-166208", "R-XTR-1632852", "R-XTR-9639288", "R-XTR-166208", "R-XTR-5628897", "R-HSA-8943724", "R-HSA-165159", "R-HSA-1632852", "R-MMU-166208", "R-MMU-5628897", "R-HSA-380972", "R-XTR-380972", "R-BTA-8943724"], "pathways": ["R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-1632852:r:Macroautophagy", "R-DDI-165159:r:MTOR signalling", "R-BTA-166208:r:mTORC1-mediated signalling", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-165159:r:MTOR signalling", "R-MMU-1632852:r:Macroautophagy", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-BTA-165159:r:MTOR 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regulation of mTOR by LKB1-AMPK", "R-XTR-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-8943724:r:Regulation of PTEN gene transcription"], "type": "Family"}, "IPR024137": {"description": "Histone deacetylase complex subunit SAP130", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "His_deAcase_cplx_SAP130", "pathway_ids": ["R-HSA-3214847", "R-HSA-427413"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones", "R-HSA-427413:r:NoRC negatively regulates rRNA expression"], "type": "Family"}, "IPR024138": {"description": "Pericentriolar material 1 protein", "go_ids": ["GO:0071539", "GO:0005813", "GO:0034454", "GO:0060271"], "go_terms": ["GO:0071539:protein localization to centrosome:P", "GO:0005813:centrosome:C", "GO:0034454:microtubule anchoring at centrosome:P", "GO:0060271:cilium assembly:P"], "name": "Pericentriolar_Pcm1", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-2565942", "R-MMU-8854518", 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"R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR024140": {"description": "Phorbol-12-myristate-13-acetate-induced protein 1", "go_ids": ["GO:0006974", "GO:0001836", "GO:0006915", "GO:0043065"], "go_terms": ["GO:0006974:DNA damage response:P", "GO:0001836:release of cytochrome c from mitochondria:P", "GO:0006915:apoptotic process:P", "GO:0043065:positive regulation of apoptotic process:P"], "name": "Noxa", "pathway_ids": ["R-RNO-111453", "R-MMU-111453", "R-CFA-111448", "R-HSA-111453", "R-CFA-111453", "R-MMU-111448", "R-RNO-111448", "R-HSA-6803204", "R-HSA-111448"], "pathways": ["R-RNO-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-MMU-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-CFA-111448:r:Activation of NOXA and translocation to mitochondria", "R-HSA-111453:r:BH3-only proteins associate with and 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"R-DME-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SPO-199992:r:trans-Golgi Network Vesicle Budding", "R-DME-8854214:r:TBC/RABGAPs", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-PFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-9845576:r:Glycosphingolipid transport", "R-MMU-8875656:r:MET receptor recycling", "R-SCE-6811438:r:Intra-Golgi traffic", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-8875656:r:MET receptor recycling", "R-BTA-6811438:r:Intra-Golgi traffic", "R-SSC-8875656:r:MET receptor recycling", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR024158": {"description": "Mitochondrial import protein TIM15", "go_ids": [], "go_terms": [], "name": "Mt_import_TIM15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024161": {"description": "Zinc finger, nanos-type", "go_ids": [], "go_terms": [], "name": "Znf_nanos-typ", "pathway_ids": ["R-HSA-9827857"], "pathways": ["R-HSA-9827857:r:Specification of primordial germ cells"], "type": "Domain"}, "IPR024162": {"description": "Adaptor protein Cbl", "go_ids": ["GO:0004842", "GO:0023051"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F", "GO:0023051:regulation of signaling:P"], "name": "Adaptor_Cbl", "pathway_ids": ["PWY-7511", "R-HSA-8849469", "R-MMU-8856828", "R-MMU-182971", "R-MMU-1433559", "R-HSA-1059683", "R-MMU-8856825", "R-HSA-8856828", "R-HSA-912631", "R-MMU-1295596", "R-HSA-1236382", "R-RNO-983168", "R-MMU-5654732", "R-HSA-2173789", "R-HSA-9706369", "R-MMU-912631", "R-HSA-182971", "R-HSA-5654727", "R-MMU-2173789", "R-MMU-8849469", "R-HSA-5654726", "R-HSA-5654732", "R-MMU-9706369", "R-HSA-6807004", "R-HSA-983168", "R-HSA-5637810", "R-HSA-9706377", "R-MMU-5654726", "R-HSA-1433559", "R-MMU-1059683", "R-HSA-1295596", "R-HSA-8856825", "R-MMU-5654727", "R-MMU-983168", "R-MMU-5654733", "R-MMU-6807004", "R-HSA-5654733", "R-HSA-8875360", "R-HSA-9680350"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-182971:r:EGFR downregulation", "R-MMU-1433559:r:Regulation of KIT signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-912631:r:Regulation of signaling by CBL", "R-HSA-182971:r:EGFR downregulation", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells"], "type": "Family"}, "IPR024163": {"description": "Aerotolerance regulator, N-terminal", "go_ids": [], "go_terms": [], "name": "Aerotolerance_reg_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024164": {"description": "KinB-signalling pathway activation protein", "go_ids": ["GO:0045881"], "go_terms": ["GO:0045881:positive regulation of sporulation resulting in formation of a cellular spore:P"], "name": 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proteins", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-8875656:r:MET receptor recycling", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-CFA-8875791:r:MET activates STAT3", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR024175": {"description": "Peptidase S1A, complement C1r/C1S/mannan-binding", "go_ids": ["GO:0004252", "GO:0005576", "GO:0006956"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0005576:extracellular region:C", "GO:0006956:complement activation:P"], "name": "Pept_S1A_C1r/C1S/mannan-bd", "pathway_ids": ["R-HSA-173623", "R-MMU-977606", "R-HSA-9705671", "R-HSA-9920588", "R-HSA-3000480", "R-RNO-166662", "R-MMU-2855086", "R-MMU-3000480", "R-MMU-166662", "R-HSA-2855086", "R-MMU-173623", "R-RNO-977606", "R-RNO-2855086", "R-HSA-977606", "R-RNO-173623", "R-HSA-166662", 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arenaviridae", "go_ids": ["GO:0046761"], "go_terms": ["GO:0046761:viral budding from plasma membrane:P"], "name": "RING_finger_Z_arenaviridae", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024184": {"description": "Uncharacterised conserved protein UCP005637", "go_ids": [], "go_terms": [], "name": "UCP005637", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024185": {"description": "5-formyltetrahydrofolate cyclo-ligase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "FTHF_cligase-like_sf", "pathway_ids": ["R-SCE-196757", "R-SPO-196757", "R-HSA-196757", "R-MMU-196757", "R-CEL-196757"], "pathways": ["R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Homologous_superfamily"}, "IPR024186": {"description": "Signal transduction response 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"GO:0006303:double-strand break repair via nonhomologous end joining:P", "GO:0006310:DNA recombination:P", "GO:0003684:damaged DNA binding:F", "GO:0043564:Ku70:Ku80 complex:C", "GO:0000723:telomere maintenance:P", "GO:0042162:telomeric repeat DNA binding:F"], "name": "Ku80", "pathway_ids": ["R-HSA-3270619", "R-HSA-6798695", "R-HSA-5693571", "R-DDI-6798695", "R-SPO-6798695", "R-DDI-5693571", "R-HSA-1834949", "R-SCE-6798695", "R-MMU-6798695", "R-MMU-5693571", "R-HSA-164843"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Family"}, "IPR024194": {"description": "Alginate O-acetyltransferase AlgI/D-alanyl transfer protein DltB", "go_ids": ["GO:0016746"], "go_terms": ["GO:0016746:acyltransferase activity:F"], "name": "Ac/AlaTfrase_AlgI/DltB", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", 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"PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR024195": {"description": "NUDIX hydrolase, YfcD, predicted", "go_ids": ["GO:0016817"], "go_terms": ["GO:0016817:hydrolase activity, acting on acid anhydrides:F"], "name": "NUDIX_hydrolase_YfcD_pred", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024196": {"description": "[NiFe]-hydrogenase-3-type complex Eha, EhaR", "go_ids": [], "go_terms": [], "name": "NiFe_hyd_3_EhaR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024197": {"description": "Trehalose phosphatase-like", "go_ids": [], "go_terms": [], "name": "TPP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024198": {"description": "Uncharacterised conserved protein, UCP033642", "go_ids": [], "go_terms": [], "name": "UCP033642", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024199": {"description": "Uncharacterised conserved protein, DsbB-like", "go_ids": [], "go_terms": [], "name": "Uncharacterised_DsbB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024200": {"description": "Chondroitin sulfate ABC endolyase", "go_ids": ["GO:0005975", "GO:0034000"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0034000:chondroitin-sulfate-ABC endolyase activity:F"], "name": "Chondroitinase_ABC_I", "pathway_ids": ["PWY-7646", "PWY-6572"], "pathways": ["PWY-7646:t:dermatan sulfate degradation I (bacterial)", "PWY-6572:t:chondroitin sulfate degradation I (bacterial)"], "type": "Family"}, "IPR024201": {"description": "Calcineurin-like phosphoesterase", "go_ids": [], "go_terms": [], "name": "Calcineurin-like_Pesterase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024203": {"description": "5-deoxy-glucuronate isomerase, IolB", "go_ids": ["GO:0019310", "GO:0008880"], "go_terms": ["GO:0019310:inositol catabolic process:P", "GO:0008880:glucuronate isomerase activity:F"], "name": "Deoxy-glucuronate_isom_IolB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024204": {"description": "Cytochrome P450, cholesterol 7-alpha-monooxygenase-type", "go_ids": ["GO:0005506", "GO:0004497", "GO:0020037", "GO:0016705"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0004497:monooxygenase activity:F", "GO:0020037:heme binding:F", "GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F"], "name": "Cyt_P450_CYP7A1-type", "pathway_ids": ["R-MMU-211994", "R-HSA-1989781", "R-RNO-193807", "R-HSA-2162123", "R-HSA-193775", "R-SSC-193368", "R-DRE-211979", "R-MMU-193368", "R-RNO-2162123", "R-MMU-2162123", "R-MMU-193775", "R-MMU-192105", "R-HSA-193368", "R-HSA-192105", "R-BTA-211979", "R-HSA-5579013", "R-SSC-211976", "R-HSA-193807", "R-HSA-211979", "R-MMU-211979", "R-RNO-192105", "R-SSC-193807", "R-RNO-211979", "R-DRE-2162123", "R-BTA-2162123", "R-HSA-211994", "R-MMU-211976", "R-RNO-211976", "R-RNO-193368", "R-SSC-192105", "R-HSA-211976", "R-MMU-193807"], "pathways": ["R-MMU-211994:r:Sterols are 12-hydroxylated by CYP8B1", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-SSC-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DRE-211979:r:Eicosanoids", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-BTA-211979:r:Eicosanoids", "R-HSA-5579013:r:Defective CYP7B1 causes SPG5A and CBAS3", "R-SSC-211976:r:Endogenous sterols", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-211979:r:Eicosanoids", "R-MMU-211979:r:Eicosanoids", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-SSC-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-RNO-211979:r:Eicosanoids", "R-DRE-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-BTA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-211994:r:Sterols are 12-hydroxylated by CYP8B1", "R-MMU-211976:r:Endogenous sterols", "R-RNO-211976:r:Endogenous sterols", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SSC-192105:r:Synthesis of bile acids and bile salts", "R-HSA-211976:r:Endogenous sterols", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "type": "Family"}, "IPR024205": {"description": "Mst1/2 SARAH domain", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "Mst1_2_SARAH_domain", "pathway_ids": ["R-BTA-2028269", "R-DME-390150", "R-DME-390098", "R-DRE-2028269", "R-CEL-2028269", "R-MMU-2028269", "R-RNO-2028269", "R-DME-390089", "R-DME-451806", "R-DME-2028269", "R-HSA-2028269"], "pathways": ["R-BTA-2028269:r:Signaling by Hippo", "R-DME-390150:r:DS ligand bound to FT receptor", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-DRE-2028269:r:Signaling by Hippo", "R-CEL-2028269:r:Signaling by Hippo", "R-MMU-2028269:r:Signaling by Hippo", "R-RNO-2028269:r:Signaling by Hippo", "R-DME-390089:r:Formation of the Hippo kinase cassette", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-DME-2028269:r:Signaling by Hippo", "R-HSA-2028269:r:Signaling by Hippo"], "type": "Domain"}, "IPR024206": {"description": "Gurmarin/antimicrobial peptide", "go_ids": [], "go_terms": [], "name": "Gurmarin/antimicrobial_peptd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024207": {"description": "Protein CotJB, domain", "go_ids": [], "go_terms": [], "name": "CotJB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024208": {"description": "Protein of unknown function DUF3842", "go_ids": [], "go_terms": [], "name": "DUF3842", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024209": {"description": "Spore surface protein CDIF630_02480", "go_ids": [], "go_terms": [], "name": "CDIF630_02480-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024210": {"description": "Protein of unknown function DUF3785", "go_ids": [], "go_terms": [], "name": "DUF3785", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024211": {"description": "Protein of unknown function DUF3841", "go_ids": [], "go_terms": [], "name": "DUF3841", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024212": {"description": "Domain of unknown function DUF3837", "go_ids": [], "go_terms": [], "name": "DUF3837", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024213": {"description": "Protein of unknown function DUF3822", "go_ids": [], "go_terms": [], "name": "DUF3822", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024214": {"description": "Protein of unknown function DUF3843", "go_ids": [], "go_terms": [], "name": "DUF3843", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024215": {"description": "Protein of unknown function DUF3847", "go_ids": [], "go_terms": [], "name": "DUF3847", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024216": {"description": "Protein of unknown function DUF3851", "go_ids": [], "go_terms": [], "name": "DUF3851", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024217": {"description": "Protein of unknown function DUF3813", "go_ids": [], "go_terms": [], "name": "DUF3813", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024218": {"description": "Protein of unknown function DUF3867", "go_ids": [], "go_terms": [], "name": "DUF3867", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024219": {"description": "Protein of unknown function DUF3809", "go_ids": [], "go_terms": [], "name": "DUF3809", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024220": {"description": "Protein of unknown function DUF3780", "go_ids": [], "go_terms": [], "name": "DUF3780", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024221": {"description": "Beta-lactamase-inhibitor protein BLIP domain superfamily", "go_ids": [], "go_terms": [], "name": "BLIP_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024222": {"description": "CST complex subunit Ten1, fungal", "go_ids": ["GO:1990879", "GO:0043047", "GO:0016233"], "go_terms": ["GO:1990879:CST complex:C", "GO:0043047:single-stranded telomeric DNA binding:F", "GO:0016233:telomere capping:P"], "name": "Ten1_fungal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024224": {"description": "DENND6", "go_ids": ["GO:0005085"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "DENND6", "pathway_ids": ["R-DDI-8876198", "R-HSA-8876198", "R-MMU-8876198"], "pathways": ["R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR024227": {"description": "Domain of unknown function DUF3795", "go_ids": [], "go_terms": [], "name": "DUF3795", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024228": {"description": "Regulatory protein NPR, central domain", "go_ids": [], "go_terms": [], "name": "NPR_central_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024229": {"description": "Protein of unknown function DUF3781", "go_ids": [], "go_terms": [], "name": "DUF3781", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024230": {"description": "GspL, cytoplasmic actin-ATPase-like domain", "go_ids": [], "go_terms": [], "name": "GspL_cyto_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024231": {"description": "Poly(A) polymerase, nucleotidyltransferase domain, Poxvirus", "go_ids": ["GO:1990817"], "go_terms": ["GO:1990817:poly(A) RNA polymerase activity:F"], "name": "PolyA_pol_nucTrfase_Poxvir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024232": {"description": "Stage III sporulation protein AH-like", "go_ids": [], "go_terms": [], "name": "SpoIIIAH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024234": {"description": "Protein of unknown function DUF3801", "go_ids": [], "go_terms": [], "name": "DUF3801", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024237": {"description": "VirE1", "go_ids": ["GO:0005515", "GO:0006457"], "go_terms": ["GO:0005515:protein binding:F", "GO:0006457:protein folding:P"], "name": "VirE1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024238": {"description": "Initiator binding protein 39kDa, C-terminal", "go_ids": [], "go_terms": [], "name": "IBP39_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024239": {"description": "Exopolysaccharide production repressor", "go_ids": [], "go_terms": [], "name": "SyrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024240": {"description": "Alpha-N-acetylglucosaminidase, N-terminal", "go_ids": [], "go_terms": [], "name": "NAGLU_N", "pathway_ids": ["R-HSA-2024096", "R-HSA-2206282"], "pathways": ["R-HSA-2024096:r:HS-GAG degradation", "R-HSA-2206282:r:MPS IIIB - Sanfilippo syndrome B"], "type": "Domain"}, "IPR024242": {"description": "Non-classical export protein 1", "go_ids": ["GO:0009306"], "go_terms": ["GO:0009306:protein secretion:P"], "name": "NCE101", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024244": {"description": "Protein of unknown function DUF2537", "go_ids": [], "go_terms": [], "name": "DUF2537", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024245": {"description": "Cell wall synthesis protein CwsA", "go_ids": [], "go_terms": [], "name": "CwsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024246": {"description": "Protein of unknown function DUF2674", "go_ids": [], "go_terms": [], "name": "DUF2674", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024247": {"description": "Protein of unknown function DUF2673", "go_ids": [], "go_terms": [], "name": "DUF2673", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024248": {"description": "Protein of unknown function DUF2695", "go_ids": [], "go_terms": [], "name": "DUF2695", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024249": {"description": "Protein of unknown function DUF2761", "go_ids": [], "go_terms": [], "name": "DUF2761", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024250": {"description": "Protein of unknown function DUF2711", "go_ids": [], "go_terms": [], "name": "DUF2711", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024251": {"description": "Membrane protein, Torovirus", "go_ids": [], "go_terms": [], "name": "M_Torovirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024252": {"description": "Ea10", "go_ids": [], "go_terms": [], "name": "DUF2528", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024253": {"description": "Phosducin, thioredoxin-like domain", "go_ids": [], "go_terms": [], "name": "Phosducin_thioredoxin-like_dom", "pathway_ids": ["R-RNO-6814122", "R-HSA-6814122", "R-BTA-6814122", "R-DME-6814122", "R-MMU-6814122"], "pathways": ["R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Domain"}, "IPR024254": {"description": "MJ0366-like", "go_ids": [], "go_terms": [], "name": "MJ0366-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024255": {"description": "Spore germination GerPB", "go_ids": [], "go_terms": [], "name": "GerPB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024256": {"description": "Domain of unknown function DUF3797", "go_ids": [], "go_terms": [], "name": "DUF3797", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024258": {"description": "Protein of unknown function DUF3798", "go_ids": [], "go_terms": [], "name": "DUF3798", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024259": {"description": "Alkylmercury lyase, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "MerB_HTH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024260": {"description": "Vacuolar segregation subunit 7", "go_ids": [], "go_terms": [], "name": "Vac7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024261": {"description": "RNA binding protein She2", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "RNA-bd_She2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024263": {"description": "Stn1, C-terminal, fungi", "go_ids": ["GO:1990879", "GO:0016233"], "go_terms": ["GO:1990879:CST complex:C", "GO:0016233:telomere capping:P"], "name": "Stn1_C_fungi", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024264": {"description": "Domain of unknown function DUF3786", "go_ids": [], "go_terms": [], "name": "DUF3786", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024265": {"description": "Protein of unknown function DUF3788", "go_ids": [], "go_terms": [], "name": "DUF3788", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024266": {"description": "Domain of unknown function DUF3806", "go_ids": [], "go_terms": [], "name": "DUF3806", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024267": {"description": "Domain of unknown function DUF4878", "go_ids": [], "go_terms": [], "name": "DUF4878", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024268": {"description": "rRNA methyltransferase AviRa", "go_ids": [], "go_terms": [], "name": "AviRa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024269": {"description": "Protein of unknown function DUF3791", "go_ids": [], "go_terms": [], "name": "DUF3791", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024270": {"description": "Urocortin II/III", "go_ids": ["GO:0007586", "GO:0051431", "GO:0005576"], "go_terms": ["GO:0007586:digestion:P", "GO:0051431:corticotropin-releasing hormone receptor 2 binding:F", "GO:0005576:extracellular region:C"], "name": "Urocortin_II/III", "pathway_ids": ["R-HSA-373080", "R-BTA-373080", "R-RNO-373080", "R-MMU-373080"], "pathways": ["R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-BTA-373080:r:Class B/2 (Secretin family receptors)", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-373080:r:Class B/2 (Secretin family receptors)"], "type": "Family"}, "IPR024271": {"description": "Protein of unknown function DUF3782", "go_ids": [], "go_terms": [], "name": "DUF3782", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024272": {"description": "MAFF2-related", "go_ids": [], "go_terms": [], "name": "MAFF-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024274": {"description": "Anaphase-promoting complex, subunit 9", "go_ids": ["GO:0005680"], "go_terms": ["GO:0005680:anaphase-promoting complex:C"], "name": "APC9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024276": {"description": "Crustacean cardioactive peptide", "go_ids": [], "go_terms": [], "name": "CCAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024277": {"description": "Domain of unknown function DUF3821", "go_ids": [], "go_terms": [], "name": "DUF3821", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024278": {"description": "DUF3823, N-terminal", "go_ids": [], "go_terms": [], "name": "DUF3823_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024279": {"description": "Paramyxovirinae protein V, zinc-binding domain", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Paramyx_V_Zn-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024280": {"description": "FAM167", "go_ids": [], "go_terms": [], "name": "FAM167", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024281": {"description": "Bacteriophage T7-like virion assembly protein", "go_ids": [], "go_terms": [], "name": "Phage_T7-like_viron_assmbl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024282": {"description": "Domain of unknown function DUF3376", "go_ids": [], "go_terms": [], "name": "DUF3376", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024283": {"description": "Translocase of chloroplast 159/132, membrane anchor domain", "go_ids": [], "go_terms": [], "name": "TOC159_MAD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024284": {"description": "Protein of unknown function DUF3826", "go_ids": [], "go_terms": [], "name": "DUF3826", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024285": {"description": "Schizont-infected cell agglutination, extracellular beta domain", "go_ids": [], "go_terms": [], "name": "SICA_extracell_b", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024286": {"description": "Domain of unknown function DUF3700", "go_ids": [], "go_terms": [], "name": "DUF3700", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024288": {"description": "Schizont-infected cell agglutination, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SICA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024289": {"description": "Domain of unknown function DUF3828", "go_ids": [], "go_terms": [], "name": "DUF3828", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024290": {"description": "Schizont-infected cell agglutination, extracellular alpha domain", "go_ids": [], "go_terms": [], "name": "SICA_extracell_a", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024291": {"description": "Protein of unknown function DUF3829", "go_ids": [], "go_terms": [], "name": "DUF3829", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024292": {"description": "Nodavirus capsid", "go_ids": [], "go_terms": [], "name": "Nodavirus_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024293": {"description": "SAC3 helical domain", "go_ids": [], "go_terms": [], "name": "SAC3_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024294": {"description": "Protein of unknown function DUF3810", "go_ids": [], "go_terms": [], "name": "DUF3810", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024295": {"description": "Protein of unknown function DUF2705", "go_ids": [], "go_terms": [], "name": "DUF2705", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024296": {"description": "Protein of unknown function DUF2710", "go_ids": [], "go_terms": [], "name": "DUF2710", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024297": {"description": "Inorganic phosphate transporter chaperone Pho86", "go_ids": [], "go_terms": [], "name": "Pho86", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024298": {"description": "Sec16, Sec23-binding domain", "go_ids": [], "go_terms": [], "name": "Sec16_Sec23-bd", "pathway_ids": ["R-HSA-204005", "R-HSA-983170", "R-MMU-204005", "R-HSA-381038", "R-HSA-2132295", "R-DDI-204005", "R-RNO-983170", "R-RNO-2132295", "R-MMU-2132295", "R-MMU-983170", "R-CEL-204005", "R-SCE-204005", "R-SPO-204005", "R-HSA-9725370", "R-RNO-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR024299": {"description": "NigD-like N-terminal OB domain", "go_ids": [], "go_terms": [], "name": "NigD-like_OB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024300": {"description": "SipL, SPOCS domain", "go_ids": [], "go_terms": [], "name": "SipL_SPOCS_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024302": {"description": "SusD-like", "go_ids": [], "go_terms": [], "name": "SusD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024303": {"description": "Natural killer cell receptor 2B4, immunoglobulin domain", "go_ids": [], "go_terms": [], "name": "NK_rcpt_2B4_Ig_dom", "pathway_ids": ["R-RNO-202733", "R-MMU-202733", "R-HSA-202733"], "pathways": ["R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR024305": {"description": "Single-stranded DNA binding protein DdrB-like", "go_ids": [], "go_terms": [], "name": "ssDNA-bd_DdrB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024307": {"description": "Spore germination protein GerY", "go_ids": [], "go_terms": [], "name": "GerY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024309": {"description": "Nuclear Testis protein, N-terminal", "go_ids": [], "go_terms": [], "name": "NUT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024310": {"description": "NUT family", "go_ids": [], "go_terms": [], "name": "NUT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024311": {"description": "Lipocalin-like domain", "go_ids": [], "go_terms": [], "name": "Lipocalin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024312": {"description": "TACC, C-terminal, fungi", "go_ids": [], "go_terms": [], "name": "TACC_C_fungi", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024314": {"description": "Suppressor of fused C-terminal", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "SUFU_C", "pathway_ids": ["R-HSA-5610780", "R-MMU-5610780", "R-HSA-5610785", "R-MMU-5632684", "R-MMU-5610785", "R-HSA-5610787", "R-MMU-5610787", "R-HSA-5610783", "R-HSA-5632684"], "pathways": ["R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-5610780:r:Degradation of GLI1 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"R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR024318": {"description": "Negative regulator of Ofd1/Enhancer of translation termination 1", "go_ids": ["GO:0005634", "GO:0005515"], "go_terms": ["GO:0005634:nucleus:C", "GO:0005515:protein binding:F"], "name": "Nro1/ETT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024319": {"description": "ATPase expression protein 2, mitochondrial", "go_ids": [], "go_terms": [], "name": "ATPase_expression_mit", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024320": {"description": "Phosphatidylglycerol lysyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "LPG_synthase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024321": {"description": "Protease inhibitor, falstatin", "go_ids": [], "go_terms": [], "name": "Prot_Inh_falstatin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024322": {"description": "Protein of unknown function DUF2682", "go_ids": [], "go_terms": [], "name": "DUF2682", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024324": {"description": "Condensin complex subunit 1, N-terminal", "go_ids": [], "go_terms": [], "name": "Condensin_cplx_su1_N", "pathway_ids": ["R-MMU-2514853", "R-HSA-2514853", "R-SCE-2514853", "R-SPO-2514853"], "pathways": ["R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes"], "type": "Domain"}, "IPR024325": {"description": "Domain of unknown function DUF3835", "go_ids": [], "go_terms": [], "name": "DUF3835", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024326": {"description": "Ribosomal RNA-processing protein 7, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RRP7_C", "pathway_ids": ["R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR024328": {"description": "Protein of unknown function DUF3845", "go_ids": [], "go_terms": [], "name": "DUF3845", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024329": {"description": "Amyloidogenic glycoprotein, E2 domain", "go_ids": [], "go_terms": [], "name": "Amyloid_glyco_E2_domain", "pathway_ids": ["R-MMU-416476", "R-SSC-432720", "R-DME-381426", "R-HSA-879415", "R-MMU-9837999", "R-MMU-444473", "R-DME-8957275", "R-HSA-3000178", "R-HSA-977225", "R-HSA-933542", "R-RNO-444473", "R-SSC-114608", "R-HSA-8862803", "R-CEL-3000178", "R-HSA-416476", "R-MMU-933542", "R-RNO-9609523", "R-DME-3000178", "R-MMU-418594", "R-MMU-8957275", "R-RNO-114608", "R-RNO-418594", "R-CEL-416476", "R-HSA-114608", "R-CEL-9609523", "R-MMU-445989", "R-MMU-3000178", "R-RNO-8957275", "R-SSC-933542", "R-MMU-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-444473", "R-DME-9609523", "R-HSA-9837999", "R-MMU-432720", "R-HSA-9609523", "R-MMU-9609523", "R-SSC-445989", "R-RNO-416476", "R-RNO-3000178", "R-HSA-381426", "R-SSC-3000178", "R-HSA-844456", "R-SSC-381426", "R-SSC-8957275", "R-RNO-432720", "R-HSA-432720", "R-DME-114608", "R-DME-9837999", "R-HSA-9660826", "R-MMU-879415", "R-HSA-445989", "R-SSC-9609523", "R-CEL-114608", "R-RNO-9837999", "R-SSC-879415", "R-RNO-381426", "R-HSA-418594", "R-RNO-879415", "R-RNO-445989", "R-SSC-9837999", "R-HSA-8957275", "R-RNO-933542", "R-MMU-114608"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-SSC-114608:r:Platelet degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-3000178:r:ECM proteoglycans", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-416476:r:G alpha (q) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-HSA-844456:r:The NLRP3 inflammasome", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-114608:r:Platelet degranulation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-114608:r:Platelet degranulation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR024330": {"description": "Protein of unknown function DUF3852", "go_ids": [], "go_terms": [], "name": "DUF3852", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024331": {"description": "Domain of unknown function DUF3859", "go_ids": [], "go_terms": [], "name": "DUF3859", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024332": {"description": "MOZART2 family", "go_ids": [], "go_terms": [], "name": "MOZART2", "pathway_ids": ["R-HSA-380320", "R-BTA-380270", "R-BTA-380320", "R-MMU-380270", "R-DRE-380320", "R-XTR-380270", "R-HSA-380270", "R-XTR-380320", "R-MMU-380320"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes"], "type": "Family"}, "IPR024333": {"description": "Mating-type protein A-alpha/beta 1, N-terminal", "go_ids": [], "go_terms": [], "name": "Mating-type_A-alpha/beta_1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024334": {"description": "Domain of unknown function DUF3863", "go_ids": [], "go_terms": [], "name": "DUF3863", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024335": {"description": "Domain of unknown function DUF3864", "go_ids": [], "go_terms": [], "name": "DUF3864", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024336": {"description": "tRNA-splicing endonuclease, subunit Sen54, N-terminal", "go_ids": [], "go_terms": [], "name": "tRNA_splic_suSen54_N", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR024337": {"description": "tRNA-splicing endonuclease, subunit Sen54", "go_ids": [], "go_terms": [], "name": "tRNA_splic_suSen54", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR024338": {"description": "Stretch-activated cation channel MID1/Yam8", "go_ids": ["GO:0005262", "GO:0098703"], "go_terms": ["GO:0005262:calcium channel activity:F", "GO:0098703:calcium ion import across plasma membrane:P"], "name": "MID1/Yam8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024339": {"description": "Protein of unknown function DUF3836", "go_ids": [], "go_terms": [], "name": "DUF3836", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024340": {"description": "Sec16, central conserved domain", "go_ids": [], "go_terms": [], "name": "Sec16_CCD", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-RNO-204005", "R-CEL-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-CEL-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR024341": {"description": "Protein of unknown function DUF2631", "go_ids": [], "go_terms": [], "name": "DUF2631", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024342": {"description": "Bacteriophage baseplate structural protein Gp28", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024343": {"description": "Capsid protein VP4, dicistrovirus", "go_ids": [], "go_terms": [], "name": "VP4_dicistrovir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024344": {"description": "Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "MDMPI_metal-binding", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024345": {"description": "DNA maturase, bacteriophage T7-like", "go_ids": [], "go_terms": [], "name": "DNA_matur_Phage_T7-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024346": {"description": "Tegument protein, herpes virus, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Tegument_herpes_virus_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024347": {"description": "GB virus, envelope protein", "go_ids": [], "go_terms": [], "name": "GB_virus_envelope", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024348": {"description": "Peptidase C62, gill-associated virus", "go_ids": [], "go_terms": [], "name": "Pept_C62_gill-assoc_virus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024349": {"description": "Human herpesvirus 5 RL5A/RL6", "go_ids": [], "go_terms": [], "name": "HHV5_RL5A/RL6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024350": {"description": "Hepatitus C virus, Non-structural 5a protein, C-terminal", "go_ids": [], "go_terms": [], "name": "HCV_NS5a_C", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR024351": {"description": "Tegument protein UL11, Herpesvirus", "go_ids": [], "go_terms": [], "name": "Tegument_UL11_Herpesvir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024353": {"description": "Protein of unknown function DUF3871", "go_ids": [], "go_terms": [], "name": "DUF3871", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024354": {"description": "Hepatitis A virus, protein VP1-2A", "go_ids": [], "go_terms": [], "name": "Hepatitis_A_VP1-2A", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Family"}, "IPR024355": {"description": "Conjugative transposon protein TraQ, bacteroidetes", "go_ids": [], "go_terms": [], "name": "TraQ_bacteroidetes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024356": {"description": "Protein of unknown function DUF3873", "go_ids": [], "go_terms": [], "name": "DUF3873", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024357": {"description": "Argonaut, glycine-rich domain", "go_ids": [], "go_terms": [], "name": "Argonaut_Gly-rich", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024358": {"description": "Non-structural protein NSP3, N-terminal, betacoronavirus", "go_ids": [], "go_terms": [], "name": "NSP3_N_bCoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR024359": {"description": "Peroxisome assembly protein 22", "go_ids": [], "go_terms": [], "name": "Peroxin-22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024360": {"description": "Cytoplasmic envelopment protein 3, herpesvirus", "go_ids": [], "go_terms": [], "name": "Herpesvirus_CEP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024361": {"description": "Bacteroidetes-Associated Carbohydrate-binding Often N-terminal", "go_ids": [], "go_terms": [], "name": "BACON", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024362": {"description": "Y11A", "go_ids": [], "go_terms": [], "name": "Y11A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024363": {"description": "Protein of unknown function DUF3853", "go_ids": [], "go_terms": [], "name": "DUF3853", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024364": {"description": "Baseplate hub assembly protein Gp26/51 domain", "go_ids": [], "go_terms": [], "name": "Gp26/51_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024365": {"description": "Protein of unknown function DUF3839", "go_ids": [], "go_terms": [], "name": "DUF3839", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024366": {"description": "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal", "go_ids": [], "go_terms": [], "name": "FTO_C", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-HSA-73943", "R-RNO-73943", "R-MMU-73943"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-HSA-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-RNO-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-MMU-73943:r:Reversal of alkylation damage by DNA dioxygenases"], "type": "Domain"}, "IPR024367": {"description": "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain", "go_ids": [], "go_terms": [], "name": "FTO_cat_dom", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-HSA-73943", "R-RNO-73943", "R-MMU-73943"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-HSA-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-RNO-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-MMU-73943:r:Reversal of alkylation damage by DNA dioxygenases"], "type": "Domain"}, "IPR024368": {"description": "Extender of the chronological lifespan protein Ecl1/2/3", "go_ids": [], "go_terms": [], "name": "Ecl1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024370": {"description": "PBP domain", "go_ids": [], "go_terms": [], "name": "PBP_domain", "pathway_ids": ["R-HSA-9637628"], "pathways": ["R-HSA-9637628:r:Modulation by Mtb of host immune system"], "type": "Domain"}, "IPR024371": {"description": "Acetyl-coenzyme A transporter 1-like", "go_ids": ["GO:0035348", "GO:0016020", "GO:0008521"], "go_terms": ["GO:0035348:acetyl-CoA transmembrane transport:P", "GO:0016020:membrane:C", "GO:0008521:acetyl-CoA transmembrane transporter activity:F"], "name": "AcetylCoA_trans_1-like", "pathway_ids": ["R-MMU-425397", "R-SPO-425397", "R-SCE-425397", "R-HSA-425397", "R-RNO-425397", "R-HSA-5619061"], "pathways": ["R-MMU-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-SPO-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-SCE-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-HSA-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-RNO-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-HSA-5619061:r:Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"], "type": "Family"}, "IPR024372": {"description": "Proteasome component Ecm29, N-terminal", "go_ids": ["GO:0060090", "GO:0043248"], "go_terms": ["GO:0060090:molecular adaptor activity:F", "GO:0043248:proteasome assembly:P"], "name": "Ecm29_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024373": {"description": "Bacteriophage T4, IpI", "go_ids": [], "go_terms": [], "name": "Phage_T4_IpI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024374": {"description": "Bacteriophage phi-29 scaffolding protein Gp7", "go_ids": [], "go_terms": [], "name": "Phage_phi-29_Gp7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024375": {"description": "Non-structural protein NSP3, SUD-M domain, betacoronavirus", "go_ids": ["GO:0002151"], "go_terms": ["GO:0002151:G-quadruplex RNA binding:F"], "name": "NSP3_bCoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR024376": {"description": "Phlebovirus, non structural protein", "go_ids": [], "go_terms": [], "name": "RVFV_non-structural", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024377": {"description": "RNA-binding protein, B2", "go_ids": [], "go_terms": [], "name": "RNA-bd_B2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024378": {"description": "RNA-directed RNA polymerase, hantavirus, N-terminal", "go_ids": [], "go_terms": [], "name": "RNA-dir_pol_N_hantavirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024379": {"description": "Waikavirus, capsid protein 1", "go_ids": [], "go_terms": [], "name": "Waikavirus_capsid-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024380": {"description": "Domain of unknown function DUF3848", "go_ids": [], "go_terms": [], "name": "DUF3848", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024381": {"description": "Protein of unknown function DUF2561", "go_ids": [], "go_terms": [], "name": "DUF2561", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024382": {"description": "Vacuolar sorting protein Vps3844, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Vps3844_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024383": {"description": "Domain of unknown function DUF3849", "go_ids": [], "go_terms": [], "name": "DUF3849", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024384": {"description": "Protein of unknown function DUF2742", "go_ids": [], "go_terms": [], "name": "DUF2742", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024385": {"description": "Domain of unknown function DUF3854", "go_ids": [], "go_terms": [], "name": "DUF3854", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024386": {"description": "Protein of unknown function DUF2532", "go_ids": [], "go_terms": [], "name": "DUF2532", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024387": {"description": "Peptidase C3G, Picornavirus", "go_ids": [], "go_terms": [], "name": "Pept_C3G_Picornavir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024388": {"description": "Large ribosomal subunit protein mL58", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL58", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024389": {"description": "Baseplate tail-tube protein gp48, T4-like virus", "go_ids": [], "go_terms": [], "name": "Gp48_T4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024390": {"description": "RNA polymerase, 132kDa subunit, poxvirus-type", "go_ids": [], "go_terms": [], "name": "RNA_pol_132_poxvirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024391": {"description": "LDB19, N-terminal", "go_ids": [], "go_terms": [], "name": "LDB19_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024392": {"description": "Protein of unknown function DUF2688", "go_ids": [], "go_terms": [], "name": "DUF2688", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024393": {"description": "Mechanosensitive ion channel MscS, porin domain", "go_ids": [], "go_terms": [], "name": "MscS_porin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024394": {"description": "RNA polymerase, 30kDa subunit, chordopox-type, N-terminal", "go_ids": [], "go_terms": [], "name": "RNA_pol_30_chordopoxvir-type_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024395": {"description": "CLASP N-terminal domain", "go_ids": [], "go_terms": [], "name": "CLASP_N_dom", "pathway_ids": ["R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-380284", "R-XTR-380270", "R-MMU-68877", "R-DRE-2467813", "R-DRE-141444", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942", "R-XTR-141444", "R-HSA-380320", "R-XTR-5620912", "R-HSA-68877", "R-DRE-5663220", "R-MMU-5620912", "R-MMU-9648025", "R-HSA-5620912", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-MMU-141444", "R-MMU-380259", "R-HSA-2500257", "R-DRE-2500257", "R-MMU-380270", "R-XTR-5663220", "R-XTR-380284", "R-HSA-141444", "R-HSA-9648025", "R-XTR-68877", "R-HSA-380270", "R-RNO-5663220", "R-XTR-380259", "R-XTR-380320", "R-XTR-2565942", "R-MMU-8854518", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-428890", "R-HSA-380259", "R-XTR-8854518", "R-XTR-2500257", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-68877:r:Mitotic Prometaphase", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Domain"}, "IPR024396": {"description": "Conjugal transfer protein TrbD, putative", "go_ids": [], "go_terms": [], "name": "Conjug_TrbD_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024397": {"description": "Poxvirus poly(A) polymerase, catalytic subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "Poxvirus_polyA_pol_cat_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024398": {"description": "Poxvirus poly(A) polymerase, catalytic subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "Poxvirus_polyA_pol_cat_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024399": {"description": "Domain of unknown function DUF2628", "go_ids": [], "go_terms": [], "name": "DUF2628", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024400": {"description": "Protein of unknown function DUF2635", "go_ids": [], "go_terms": [], "name": "DUF2635", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024401": {"description": "WYL domain containing protein", "go_ids": [], "go_terms": [], "name": "WYL_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024402": {"description": "Domain of unknown function DUF2726", "go_ids": [], "go_terms": [], "name": "DUF2726", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024403": {"description": "Dihydroorotase, catalytic domain", "go_ids": [], "go_terms": [], "name": "DHOase_cat", "pathway_ids": ["PWY-7791", "PWY-5686", "PWY-7790", "R-DME-500753", "R-DDI-500753"], "pathways": ["PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "R-DME-500753:r:Pyrimidine biosynthesis", "R-DDI-500753:r:Pyrimidine biosynthesis"], "type": "Domain"}, "IPR024404": {"description": "Lipid-binding, putative", "go_ids": [], "go_terms": [], "name": "Lipid-bd_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024405": {"description": "Prophage protein BhlA/UviB", "go_ids": [], "go_terms": [], "name": "Phage_BhlA/UviB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024406": {"description": "Phage tail assembly chaperone TAC-10", "go_ids": [], "go_terms": [], "name": "TAC-10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024407": {"description": "Protein 3a, betacoronavirus", "go_ids": ["GO:0005216"], "go_terms": ["GO:0005216:monoatomic ion channel activity:F"], "name": "Protein_3a_bCoV", "pathway_ids": ["R-HSA-9754560", "R-HSA-9679509", "R-HSA-9705671", "R-HSA-9694719", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9692916", "R-HSA-9692913", "R-HSA-9735871", "R-HSA-166662", "R-HSA-9683673", "R-HSA-166663", "R-HSA-9694614", "R-HSA-9686347", "R-HSA-9694322", "R-HSA-9694635", "R-HSA-9755779"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9694719:r:Maturation of protein 3a", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-9683673:r:Maturation of protein 3a", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9694635:r:Translation of Structural Proteins", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways"], "type": "Family"}, "IPR024408": {"description": "N-acetylmuramidase", "go_ids": [], "go_terms": [], "name": "Muramidase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024409": {"description": "Protein of unknown function DUF3833", "go_ids": [], "go_terms": [], "name": "DUF3833", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024410": {"description": "Phage tail assembly chaperone protein, TAC", "go_ids": [], "go_terms": [], "name": "Phage_TAC_12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024411": {"description": "Tail terminator, bacteriophage", "go_ids": [], "go_terms": [], "name": "Tail_terminator_phage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024412": {"description": "Lsr2 dimerization domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Lsr2_dim_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024413": {"description": "Bacteriophage phiKZ, Orf92, internal head", "go_ids": [], "go_terms": [], "name": "Phage_phiKZ_Orf92_int-head", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024414": {"description": "Uncharacterised protein family PrgI", "go_ids": [], "go_terms": [], "name": "Uncharacterised_PrgI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024415": {"description": "Fungus-induced protein", "go_ids": [], "go_terms": [], "name": "Fungus-induced", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024416": {"description": "Protein of unknown function DUF2738", "go_ids": [], "go_terms": [], "name": "DUF2738", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024417": {"description": "Neuronal protein 3.1", "go_ids": [], "go_terms": [], "name": "Neuronal_3.1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024418": {"description": "Protein of unknown function DUF3862", "go_ids": [], "go_terms": [], "name": "DUF3862", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024419": {"description": "Protein of unknown function YvrJ", "go_ids": [], "go_terms": [], "name": "YvrJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024420": {"description": "TRAPP III complex, Trs85", "go_ids": [], "go_terms": [], "name": "TRAPP_III_complex_Trs85", "pathway_ids": ["R-SPO-8876198", "R-HSA-8876198", "R-CEL-8876198"], "pathways": ["R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR024421": {"description": "Bacteriophage P22, Mnt", "go_ids": [], "go_terms": [], "name": "Phage_P22_Mnt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024422": {"description": "Protein of unknown function, OB-fold-containing", "go_ids": [], "go_terms": [], "name": "Protein_unknown_function_OB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024423": {"description": "Protein of unknown function DUF3050", "go_ids": [], "go_terms": [], "name": "DUF3050", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024424": {"description": "Replicative helicase inhibitor G39P, N-terminal", "go_ids": [], "go_terms": [], "name": "G39P_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024425": {"description": "Cell wall-active antibiotics response LiaF-like, C-terminal", "go_ids": [], "go_terms": [], "name": "LiaF-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024426": {"description": "Protein of unknown function DUF2694", "go_ids": [], "go_terms": [], "name": "DUF2694", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024427": {"description": "Endosialidase, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "B-barrel_Endosialidase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024428": {"description": "Endosialidase, beta-propeller domain", "go_ids": ["GO:0016996"], "go_terms": ["GO:0016996:endo-alpha-(2,8)-sialidase activity:F"], "name": "Endosialidase_beta_prop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024429": {"description": "Endosialidase, N-terminal extension domain", "go_ids": [], "go_terms": [], "name": "Endosialidase_N-extension", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024430": {"description": "Endosialidase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Endosialidase_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024431": {"description": "Insertion element IS1 protein InsA, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "InsA_HTH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024432": {"description": "Putative exodeoxyribonuclease 8, PDDEXK-like domain", "go_ids": [], "go_terms": [], "name": "Put_RecE_PDDEXK-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024434": {"description": "TSCPD domain", "go_ids": [], "go_terms": [], "name": "TSCPD_dom", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR024435": {"description": "Histidyl tRNA synthetase-related domain", "go_ids": [], "go_terms": [], "name": "HisRS-related_dom", "pathway_ids": ["R-HSA-9633012"], "pathways": ["R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR024436": {"description": "Domain of unknown function DUF3824", "go_ids": [], "go_terms": [], "name": "DUF3824", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024437": {"description": "Domain of unknown function DUF3825", "go_ids": [], "go_terms": [], "name": "DUF3825", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024438": {"description": "Staygreen protein", "go_ids": [], "go_terms": [], "name": "Staygreen", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024439": {"description": "RNHCP domain", "go_ids": [], "go_terms": [], "name": "RNHCP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024440": {"description": "Colicin D, C-terminal", "go_ids": ["GO:0004540"], "go_terms": ["GO:0004540:RNA nuclease activity:F"], "name": "ColicinD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024441": {"description": "Mating-type protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Homeodomain1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024442": {"description": "Transposase, zinc-ribbon", "go_ids": [], "go_terms": [], "name": "Transposase_Zn_ribbon", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024443": {"description": "Protein of unknown function DUF3197", "go_ids": [], "go_terms": [], "name": "DUF3197", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024444": {"description": "Protein of unknown function DUF2706", "go_ids": [], "go_terms": [], "name": "DUF2706", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024445": {"description": "ISXO2-like transposase domain", "go_ids": [], "go_terms": [], "name": "Tnp_ISXO2-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024446": {"description": "PXPV repeat", "go_ids": [], "go_terms": [], "name": "PXPV", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR024447": {"description": "YXWGXW repeat", "go_ids": [], "go_terms": [], "name": "YXWGXW_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR024448": {"description": "Xylosyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "XylT_C", "pathway_ids": ["PWY-6557", "R-HSA-1971475", "R-CFA-1971475", "R-RNO-1971475", "R-MMU-1971475", "R-DME-1971475"], "pathways": ["PWY-6557:t:glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CFA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis"], "type": "Domain"}, "IPR024449": {"description": "Anti-sigma factor RsgI, N-terminal", "go_ids": [], "go_terms": [], "name": "Anti-sigma_RsgI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024450": {"description": "Domain of unknown function DUF3874", "go_ids": [], "go_terms": [], "name": "DUF3874", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024451": {"description": "TraG, N-terminal, Bacteroidetes", "go_ids": [], "go_terms": [], "name": "TraG_N_Bacteroidetes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024452": {"description": "Protein of unknown function DUF3876", "go_ids": [], "go_terms": [], "name": "DUF3876", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024453": {"description": "Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family", "go_ids": [], "go_terms": [], "name": "Peptidase_C92", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024455": {"description": "Phage capsid", "go_ids": [], "go_terms": [], "name": "Phage_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024456": {"description": "Integrase catalytic domain, putative", "go_ids": [], "go_terms": [], "name": "Integrase_catalytic_putative", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024457": {"description": "Putative integrase, N-terminal", "go_ids": [], "go_terms": [], "name": "Putative_integrase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024459": {"description": "Anti-CBASS protein Acb1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Acb1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024460": {"description": "Protamine-like", "go_ids": ["GO:0007283", "GO:0035092"], "go_terms": ["GO:0007283:spermatogenesis:P", "GO:0035092:sperm DNA condensation:P"], "name": "Protamine-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024461": {"description": "Coiled-coil domain-containing protein 90-like", "go_ids": [], "go_terms": [], "name": "CCDC90-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024462": {"description": "Glycosyl-hydrolase family 116, N-terminal", "go_ids": [], "go_terms": [], "name": "GH116_N", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-6848", "PWY-7487", "PWY-6655", "PWY-7940", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-8436", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-5976", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7057", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-7529", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-7091", "PWY-1901", "PWY-8241", "PWY-7745", "PWY-7055", "PWY-6527", "PWY-5139", "PWY-7143", "PWY-7647", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-6821", "PWY-5339", "PWY-6735", "PWY-5310", "PWY-6855", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-862", "PWY-6737", "PWY-7445", "PWY-5821", "PWY-8379", "PWY-6749", "PWY-7463", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-7134", "PWY-7133", "PWY-1921", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-6784", "PWY-7838", "PWY-7960", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-6717", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-6906", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-8435", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-7074", "PWY-8272", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8366", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-842", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-7056", "PWY-7256", "PWY-5400", "PWY-7697", "R-MMU-9840310", "R-RNO-9840310", "R-HSA-9840310", "R-DME-9840310"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-6848:t:rutin degradation", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-8436:t:mammalian high-mannose N-glycan degradation", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-5976:t:dhurrin degradation", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7057:t:cichoriin interconversion", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-7091:t:linustatin bioactivation", "PWY-1901:t:aurone biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-6527:t:stachyose degradation", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-7647:t:ulvan degradation", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-6821:t:kappa-carrageenan degradation", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-6735:t:starch degradation IV", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-6855:t:chitin degradation I (archaea)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-862:t:fructan degradation", "PWY-6737:t:starch degradation V", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-5821:t:dalcochinin biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7134:t:rutin degradation (plants)", "PWY-7133:t:quercetin glucoside degradation (Allium)", "PWY-1921:t:indole-3-acetate activation II", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-7960:t:rhabduscin biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-6717:t:(1,4)-beta-D-xylan degradation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-6906:t:chitin derivatives degradation", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-8435:t:yeast mannan degradation", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-842:t:starch degradation I", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7056:t:daphnin interconversion", "PWY-7256:t:cyanidin diglucoside biosynthesis (acyl-glucose dependent)", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-DME-9840310:r:Glycosphingolipid catabolism"], "type": "Domain"}, "IPR024463": {"description": "Transposase TnpC, homeodomain", "go_ids": [], "go_terms": [], "name": "Transposase_TnpC_homeodom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024464": {"description": "Protein of unknown function DUF2391", "go_ids": [], "go_terms": [], "name": "DUF2391", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024465": {"description": "Domain of unknown function DUF2399", "go_ids": [], "go_terms": [], "name": "DUF2399", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024466": {"description": "Conserved hypothetical protein CHP02679, N terminus", "go_ids": [], "go_terms": [], "name": "CHP02679_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024467": {"description": "Antitoxin Xre/MbcA/ParS-like, toxin-binding domain", "go_ids": [], "go_terms": [], "name": "Xre/MbcA/ParS-like_toxin-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024468": {"description": "Sec16, N-terminal", "go_ids": [], "go_terms": [], "name": "Sec16_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024469": {"description": "Protein of unknown function DUF2538", "go_ids": [], "go_terms": [], "name": "DUF2538", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024470": {"description": "Protein of unknown function DUF2545", "go_ids": [], "go_terms": [], "name": "DUF2545", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024471": {"description": "Protein of unknown function DUF2715", "go_ids": [], "go_terms": [], "name": "DUF2715", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024473": {"description": "Transposase, IS4, N-terminal", "go_ids": [], "go_terms": [], "name": "Transposases_IS4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024474": {"description": "Transposase IS66, zinc-finger binding domain of", "go_ids": [], "go_terms": [], "name": "Znf_dom_IS66", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024475": {"description": "Type IV conjugative transfer protein TrbJ/K, C-terminal", "go_ids": [], "go_terms": [], "name": "TrbJ/K_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024476": {"description": "Protein of unknown function DUF3861", "go_ids": [], "go_terms": [], "name": "DUF3861", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024477": {"description": "Protein of unknown function DUF3865, CADD-like", "go_ids": [], "go_terms": [], "name": "DUF3865_CADD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024478": {"description": "Chemotaxis methyl-accepting receptor HlyB-like, 4HB MCP domain", "go_ids": [], "go_terms": [], "name": "HlyB_4HB_MCP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024479": {"description": "Protein of unknown function DUF3866", "go_ids": [], "go_terms": [], "name": "DUF3866", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024480": {"description": "Domain of unknown function DUF3868", "go_ids": [], "go_terms": [], "name": "DUF3868", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024481": {"description": "Helicase Sen1, N-terminal", "go_ids": [], "go_terms": [], "name": "Helicase_Sen1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024482": {"description": "Domain of unknown function DUF3855", "go_ids": [], "go_terms": [], "name": "DUF3855", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024483": {"description": "Glia associated membrane protein glam-1", "go_ids": [], "go_terms": [], "name": "Glam1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024484": {"description": "CT_538/TC_0825", "go_ids": [], "go_terms": [], "name": "CT_538-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024485": {"description": "Protein of unknown function DUF2680", "go_ids": [], "go_terms": [], "name": "DUF2680", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024486": {"description": "Protein of unknown function DUF2617", "go_ids": [], "go_terms": [], "name": "DUF2617", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024487": {"description": "Cellulose biosynthesis protein BcsR-like", "go_ids": [], "go_terms": [], "name": "CBP_BcsR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024488": {"description": "Protein of unknown function DUF2777", "go_ids": [], "go_terms": [], "name": "DUF2777", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024489": {"description": "Organ specific protein", "go_ids": [], "go_terms": [], "name": "Organ_specific_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024490": {"description": "Protein of unknown function DUF2759", "go_ids": [], "go_terms": [], "name": "DUF2759", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024491": {"description": "Selenoprotein SelK/SelG", "go_ids": [], "go_terms": [], "name": "Se_SelK/SelG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024492": {"description": "CT_309/TC_0583-like", "go_ids": [], "go_terms": [], "name": "CT_309-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024493": {"description": "Fumarase D", "go_ids": [], "go_terms": [], "name": "FumD", "pathway_ids": ["PWY-8086", "PWY-7254", "PWY-6728", "PWY-5913", "PWY-7384", "PWY-561", "PWY-5690", "PWY-5392", "PWY-6969"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-6728:t:methylaspartate cycle", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)"], "type": "Family"}, "IPR024494": {"description": "Protein of unknown function DUF2770", "go_ids": [], "go_terms": [], "name": "DUF2770", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024495": {"description": "Protein of unknown function DUF2771", "go_ids": [], "go_terms": [], "name": "DUF2771", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024496": {"description": "Spore germination protein GerPE", "go_ids": [], "go_terms": [], "name": "Spore_germ_GerPE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024497": {"description": "Domain of unknown function DUF2773", "go_ids": [], "go_terms": [], "name": "DUF2773", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024498": {"description": "Domain of unknown function DUF2786", "go_ids": [], "go_terms": [], "name": "DUF2786", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024499": {"description": "Mbeg1-like", "go_ids": [], "go_terms": [], "name": "Mbeg1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024500": {"description": "Domain of unknown function DUF3074", "go_ids": [], "go_terms": [], "name": "DUF3074", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024501": {"description": "Protein of unknown function DUF3141", "go_ids": [], "go_terms": [], "name": "DUF3141", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024502": {"description": "Protein of unknown function DUF3194", "go_ids": [], "go_terms": [], "name": "DUF3194", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024503": {"description": "Protein of unknown function DUF3196", "go_ids": [], "go_terms": [], "name": "DUF3196", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024504": {"description": "Uncharacterised membrane protein Ta0354, soluble domain", "go_ids": [], "go_terms": [], "name": "Unchr_Ta0354_soluble_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024505": {"description": "Protein of unknown function DUF3201", "go_ids": [], "go_terms": [], "name": "DUF3201", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024506": {"description": "Protein of unknown function DUF3217", "go_ids": [], "go_terms": [], "name": "DUF3217", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024507": {"description": "AtzH-like", "go_ids": [], "go_terms": [], "name": "AtzH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024508": {"description": "Protein of unknown function DUF3226", "go_ids": [], "go_terms": [], "name": "DUF3226", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024509": {"description": "Anti-lipopolysaccharide factor/Scygonadin", "go_ids": [], "go_terms": [], "name": "Anti-LPS_factor/Scygonadin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024510": {"description": "Protein of unknown function DUF2589", "go_ids": [], "go_terms": [], "name": "DUF2589", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024511": {"description": "WD repeat-containing and planar cell polarity effector protein Fritz", "go_ids": [], "go_terms": [], "name": "Frtz", "pathway_ids": ["R-DME-450728"], "pathways": ["R-DME-450728:r:Inhibition of actin polymerization"], "type": "Family"}, "IPR024512": {"description": "Small subunit of serine palmitoyltransferase-like", "go_ids": [], "go_terms": [], "name": "Ser_palmitoyltrfase_ssu-like", "pathway_ids": ["R-RNO-1660661", "R-MMU-1660661", "R-DRE-1660661", "R-HSA-1660661", "R-XTR-1660661", "R-BTA-1660661"], "pathways": ["R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis", "R-DRE-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-XTR-1660661:r:Sphingolipid de novo biosynthesis", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR024513": {"description": "Protein of unknown function DUF3334", "go_ids": [], "go_terms": [], "name": "DUF3334", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024514": {"description": "Domain of unknown function DUF3388", "go_ids": [], "go_terms": [], "name": "DUF3388", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024515": {"description": "Protein of unknown function DUF3397", "go_ids": [], "go_terms": [], "name": "DUF3397", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024516": {"description": "Mammalian cell entry, C-terminal", "go_ids": [], "go_terms": [], "name": "Mce_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024517": {"description": "Glycogen phosphorylase, domain of unknown function DUF3417", "go_ids": [], "go_terms": [], "name": "Glycogen_phosphorylase_DUF3417", "pathway_ids": ["PWY-7238", "PWY-6731", "PWY-5941", "PWY-6737"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6731:t:starch degradation III", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V"], "type": "Domain"}, "IPR024519": {"description": "Inverse autotransporter, beta-domain", "go_ids": [], "go_terms": [], "name": "IAT_beta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024520": {"description": "Protein of unknown function DUF3558", "go_ids": [], "go_terms": [], "name": "DUF3558", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024521": {"description": "Arsenosugar biosynthesis radical SAM protein ArsS-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ArsS-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024522": {"description": "Protein of unknown function DUF3789", "go_ids": [], "go_terms": [], "name": "DUF3789", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024523": {"description": "Protein of unknown function DUF3793", "go_ids": [], "go_terms": [], "name": "DUF3793", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024524": {"description": "Protein of unknown function DUF3800", "go_ids": [], "go_terms": [], "name": "DUF3800", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024525": {"description": "Domain of unknown function DUF3804", "go_ids": [], "go_terms": [], "name": "DUF3804", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024526": {"description": "Protein of unknown function DUF3807", "go_ids": [], "go_terms": [], "name": "DUF3807", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024527": {"description": "Eisosome protein 1", "go_ids": [], "go_terms": [], "name": "Eisosome1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024528": {"description": "Threonine/Serine exporter, ThrE", "go_ids": [], "go_terms": [], "name": "ThrE_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024529": {"description": "ECF transporter, substrate-specific component", "go_ids": ["GO:0022857"], "go_terms": ["GO:0022857:transmembrane transporter activity:F"], "name": "ECF_trnsprt_substrate-spec", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024530": {"description": "Putative quorum-sensing-regulated virulence factor", "go_ids": [], "go_terms": [], "name": "QSregVF_b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024531": {"description": "Erythronate-4-phosphate dehydrogenase, dimerisation domain", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "Erythronate-4-P_DHase_dimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024532": {"description": "Protein of unknown function DUF3830", "go_ids": [], "go_terms": [], "name": "DUF3830", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024533": {"description": "Protein of unknown function DUF3834", "go_ids": [], "go_terms": [], "name": "DUF3834", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024534": {"description": "Wadjet protein JetD, C-terminal", "go_ids": [], "go_terms": [], "name": "JetD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024535": {"description": "Rhamnogalacturonase A/B/Epimerase-like, pectate lyase domain", "go_ids": [], "go_terms": [], "name": "RHGA/B-epi-like_pectate_lyase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024537": {"description": "Domain of unknown function DUF3322", "go_ids": [], "go_terms": [], "name": "DUF3322", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024538": {"description": "Protein of unknown function DUF3878", "go_ids": [], "go_terms": [], "name": "DUF3878", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024539": {"description": "Protein of unknown function DUF3877", "go_ids": [], "go_terms": [], "name": "DUF3877", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024540": {"description": "Protein of unknown function DUF3879", "go_ids": [], "go_terms": [], "name": "DUF3879", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024541": {"description": "Protein of unknown function DUF3881", "go_ids": [], "go_terms": [], "name": "DUF3881", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024542": {"description": "Spore protein YkvP, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YkvP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024543": {"description": "Autophagy protein Atg19/Atg34, C-terminal", "go_ids": [], "go_terms": [], "name": "Atg19/Atg34_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024544": {"description": "Domain of unknown function DUF3858", "go_ids": [], "go_terms": [], "name": "DUF3858", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024545": {"description": "Mto1-like, Mto2p-binding domain", "go_ids": [], "go_terms": [], "name": "Mto1-like_Mto2p-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024548": {"description": "Copper type II ascorbate-dependent monooxygenase, C-terminal", "go_ids": [], "go_terms": [], "name": "Cu2_monoox_C", "pathway_ids": ["R-CFA-209905", "R-DME-209905", "R-HSA-209905", "R-RNO-209905", "R-MMU-209905"], "pathways": ["R-CFA-209905:r:Catecholamine biosynthesis", "R-DME-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-RNO-209905:r:Catecholamine biosynthesis", "R-MMU-209905:r:Catecholamine biosynthesis"], "type": "Domain"}, "IPR024549": {"description": "NADH-ubiquinone oxidoreductase, 21kDa subunit, C-terminal, fungi", "go_ids": [], "go_terms": [], "name": "NADH-UbQ_OxRdtase_su21_C_fun", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024550": {"description": "TFIIEalpha/SarR/Rpc3 HTH domain", "go_ids": [], "go_terms": [], "name": "TFIIEa/SarR/Rpc3_HTH_dom", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-BTA-73776", "R-MMU-75953", "R-SCE-75953", "R-BTA-76042", "R-DDI-73776", "R-SPO-6807505", "R-HSA-167162", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-MMU-73776", "R-DDI-76042", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-BTA-73779", "R-SPO-75953", "R-SCE-73779", "R-BTA-75953", "R-DDI-73779", "R-BTA-674695", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-HSA-167161", "R-SCE-674695", "R-SPO-73779", "R-HSA-674695", "R-HSA-76042", "R-DDI-75953", "R-BTA-6807505", "R-SPO-73776", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167161:r:HIV Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR024551": {"description": "Aspartate aminotransferase Ic", "go_ids": ["GO:0004069"], "go_terms": ["GO:0004069:L-aspartate:2-oxoglutarate transaminase activity:F"], "name": "AspAT_Ic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024552": {"description": "Domain of Unknown Function DUF3856", "go_ids": [], "go_terms": [], "name": "DUF3856", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024554": {"description": "PX domain-containing protein LEC1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "LEC1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024555": {"description": "PX-associated domain", "go_ids": [], "go_terms": [], "name": "PX-associated", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024556": {"description": "Protein of unknown function DUF3599", "go_ids": [], "go_terms": [], "name": "DUF3599", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024557": {"description": "CCR4-NOT transcription complex subunit 1, domain 4", "go_ids": [], "go_terms": [], "name": "CNOT1_dom_4", "pathway_ids": ["R-XTR-429947", "R-MMU-6804115", "R-HSA-6804115", "R-XTR-6804115", "R-DRE-6804115", "R-HSA-429947", "R-MMU-429947", "R-HSA-9820841"], "pathways": ["R-XTR-429947:r:Deadenylation of mRNA", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR024558": {"description": "ComZ", "go_ids": [], "go_terms": [], "name": "ComZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024559": {"description": "Domain of unknown function DUF3846", "go_ids": [], "go_terms": [], "name": "DUF3846", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024560": {"description": "UPF0313, C-terminal", "go_ids": [], "go_terms": [], "name": "UPF0313_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024561": {"description": "Alpha-1,6-glucosidases, pullulanase-type, C-terminal", "go_ids": [], "go_terms": [], "name": "Pullul_strch_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024562": {"description": "Uncharacterised protein family YqhG", "go_ids": [], "go_terms": [], "name": "YqhG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024563": {"description": "Uncharacterised protein family YqhR", "go_ids": [], "go_terms": [], "name": "YqhR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024564": {"description": "Nitrogenase molybdenum-iron protein beta chain, N-terminal", "go_ids": [], "go_terms": [], "name": "Nase_Mo-Fe_CF_bsu_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024565": {"description": "Orexigenic neuropeptide QRFP/P518", "go_ids": ["GO:0031854"], "go_terms": ["GO:0031854:orexigenic neuropeptide QRFP receptor binding:F"], "name": "P518", "pathway_ids": ["R-MMU-416476", "R-MMU-389397", "R-HSA-416476", "R-RNO-416476", "R-HSA-389397", "R-RNO-389397"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-RNO-389397:r:Orexin and neuropeptides FF and QRFP bind to their respective receptors"], "type": "Family"}, "IPR024566": {"description": "Colicin, receptor domain", "go_ids": [], "go_terms": [], "name": "Colicin_R_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024567": {"description": "Ribonuclease HII/HIII domain", "go_ids": ["GO:0004523"], "go_terms": ["GO:0004523:RNA-DNA hybrid ribonuclease activity:F"], "name": "RNase_HII/HIII_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024568": {"description": "Ribonuclease HIII, N-terminal", "go_ids": [], "go_terms": [], "name": "RNase_HIII_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024569": {"description": "Lactate utilization protein B, C-terminal", "go_ids": [], "go_terms": [], "name": "LutB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024570": {"description": "Murein transglycosylase-C, N-terminal", "go_ids": [], "go_terms": [], "name": "Murein_transglycosylaseC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024571": {"description": "ERAP1-like C-terminal domain", "go_ids": [], "go_terms": [], "name": "ERAP1-like_C_dom", "pathway_ids": ["R-SSC-2022377", "R-HSA-6798695", "R-RNO-983170", "R-RNO-1236977", "R-CEL-983170", "R-SCE-6798695", "R-SCE-983170", "R-RNO-2022377", "R-MMU-1236977", "R-HSA-983168", "R-HSA-2022377", "R-CEL-983168", "R-HSA-1236977", "R-BTA-983170", "R-HSA-983170", "R-HSA-1445148", "R-MMU-983170", "R-MMU-983168", "R-SPO-983168", "R-MMU-6798695", "R-SCE-983168", "R-CFA-6798695", "R-RNO-983168", "R-RNO-6798695", "R-MMU-2022377"], "pathways": ["R-SSC-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-1236977:r:Endosomal/Vacuolar pathway", "R-CEL-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Domain"}, "IPR024572": {"description": "Nickel/cobalt homeostasis protein RcnB", "go_ids": [], "go_terms": [], "name": "RcnB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024573": {"description": "Domain of unknown function DUF3333", "go_ids": [], "go_terms": [], "name": "DUF3333", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024574": {"description": "ELMO, armadillo-like helical domain", "go_ids": [], "go_terms": [], "name": "ELMO_ARM", "pathway_ids": ["R-CEL-4420097", "R-CEL-8849471", "R-HSA-164944", "R-DDI-8849471", "R-MMU-9013408", "R-HSA-9013408", "R-HSA-2029482", "R-MMU-4420097", "R-HSA-9664422", "R-MMU-8849471", "R-MMU-2029482", "R-HSA-8849471", "R-HSA-4420097"], "pathways": ["R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-164944:r:Nef and signal transduction", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR024576": {"description": "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381", "go_ids": [], "go_terms": [], "name": "rRNA_MeTfrase_Spb1_DUF3381", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR024578": {"description": "Homez, homeobox domain", "go_ids": [], "go_terms": [], "name": "Homez_homeobox_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024579": {"description": "Bcl-2-interacting killer", "go_ids": ["GO:0006915"], "go_terms": ["GO:0006915:apoptotic process:P"], "name": "Bcl2-int_killer", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024580": {"description": "Dishevelled C-terminal", "go_ids": [], "go_terms": [], "name": "Dishevelled_C-dom", "pathway_ids": ["R-MMU-8856828", "R-HSA-201681", "R-RNO-4641262", "R-MMU-8856825", "R-HSA-8856828", "R-HSA-5368598", "R-XTR-8856825", "R-MMU-5099900", "R-MMU-201688", "R-XTR-4641262", "R-XTR-5099900", "R-HSA-2028269", "R-RNO-201688", "R-HSA-4641262", "R-MMU-4608870", "R-XTR-8856828", "R-RNO-4641258", "R-HSA-201688", "R-MMU-2028269", "R-RNO-4086400", "R-HSA-4086400", "R-MMU-4086400", "R-XTR-201688", "R-HSA-5099900", "R-XTR-5663220", "R-XTR-4641258", "R-HSA-9673324", "R-HSA-4641258", "R-RNO-5663220", "R-MMU-4641258", "R-HSA-4608870", "R-XTR-4086400", "R-HSA-8856825", "R-MMU-4641262", "R-HSA-5663220", "R-MMU-5663220", "R-XTR-2028269"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-201688:r:WNT mediated activation of DVL", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-2028269:r:Signaling by Hippo", "R-RNO-201688:r:WNT mediated activation of DVL", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-201688:r:WNT mediated activation of DVL", "R-MMU-2028269:r:Signaling by Hippo", "R-RNO-4086400:r:PCP/CE pathway", "R-HSA-4086400:r:PCP/CE pathway", "R-MMU-4086400:r:PCP/CE pathway", "R-XTR-201688:r:WNT mediated activation of DVL", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-4641258:r:Degradation of DVL", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-XTR-4086400:r:PCP/CE pathway", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-XTR-2028269:r:Signaling by Hippo"], "type": "Domain"}, "IPR024581": {"description": "Tbk1/Ikki binding domain", "go_ids": [], "go_terms": [], "name": "TBD", "pathway_ids": ["R-HSA-9824878", "R-HSA-933541", "R-HSA-936964", "R-HSA-9013973", "R-HSA-9828211", "R-MMU-9824878", "R-MMU-936964"], "pathways": ["R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "type": "Domain"}, "IPR024583": {"description": "Voltage-gated Na+ ion channel, cytoplasmic domain", "go_ids": [], "go_terms": [], "name": "Na_trans_cytopl", "pathway_ids": ["R-HSA-9717207", "R-HSA-445095", "R-HSA-5576892"], "pathways": ["R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-HSA-5576892:r:Phase 0 - rapid depolarisation"], "type": "Domain"}, "IPR024584": {"description": "Tuberin, N-terminal", "go_ids": [], "go_terms": [], "name": "Tuberin_N", "pathway_ids": ["R-RNO-8854214", "R-HSA-8854214", "R-MMU-380972", "R-HSA-5674400", "R-MMU-198323", "R-SPO-5628897", "R-MMU-1632852", "R-SPO-380972", "R-RNO-5628897", "R-SPO-165181", "R-RNO-165181", "R-HSA-5628897", "R-MMU-8854214", "R-SPO-198323", "R-HSA-198323", "R-RNO-1632852", "R-MMU-165181", "R-RNO-380972", "R-HSA-1632852", "R-MMU-5628897", "R-RNO-198323", "R-HSA-165181", "R-HSA-380972"], "pathways": ["R-RNO-8854214:r:TBC/RABGAPs", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-1632852:r:Macroautophagy", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-RNO-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-8854214:r:TBC/RABGAPs", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-1632852:r:Macroautophagy", "R-MMU-165181:r:Inhibition of TSC complex formation by PKB", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1632852:r:Macroautophagy", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK"], "type": "Domain"}, "IPR024585": {"description": "Serine/threonine-protein kinase mTOR domain", "go_ids": [], "go_terms": [], "name": "mTOR_dom", "pathway_ids": ["R-SCE-9639288", "R-MMU-380972", "R-CEL-1632852", "R-RNO-1257604", "R-CEL-3371571", "R-HSA-5628897", "R-RNO-166208", "R-HSA-166208", "R-CEL-8943724", "R-CEL-389357", "R-DME-166208", "R-SCE-1257604", "R-HSA-9920951", "R-SPO-6804757", "R-SPO-1257604", "R-SCE-3371571", "R-HSA-380972", "R-SPO-9856530", "R-DDI-9639288", "R-DDI-5628897", "R-DME-9639288", "R-DDI-1632852", "R-DDI-1257604", "R-MMU-5218920", "R-MMU-6804757", "R-DDI-166208", "R-MMU-3371571", "R-CEL-380972", "R-MMU-1257604", "R-DDI-3371571", "R-CEL-6804757", "R-MMU-8943724", "R-RNO-9856530", "R-DDI-8943724", "R-HSA-165159", "R-HSA-3371571", "R-DDI-389357", "R-MMU-166208", "R-HSA-9856530", "R-CEL-166208", "R-DME-9856530", "R-CEL-5218920", "R-SCE-5218920", "R-CEL-9856530", "R-SPO-3371571", "R-MMU-1632852", "R-SPO-389357", "R-MMU-9639288", "R-SPO-9639288", "R-SCE-389357", "R-DME-380972", "R-HSA-9639288", "R-RNO-5218920", "R-DDI-6804757", "R-MMU-389357", "R-HSA-5218920", "R-RNO-1632852", "R-SCE-6804757", "R-CEL-1257604", "R-DME-3371571", "R-HSA-6804757", "R-HSA-8943724", "R-DDI-5218920", "R-CEL-9639288", "R-RNO-3371571", "R-CEL-165159", "R-MMU-5628897", "R-SCE-9856530", "R-RNO-389357", "R-RNO-165159", "R-HSA-5674400", "R-MMU-165159", "R-CEL-5628897", "R-RNO-5628897", "R-SPO-5218920", "R-DDI-380972", "R-DME-5218920", "R-RNO-6804757", "R-DDI-9856530", "R-RNO-380972", "R-DME-1257604", "R-HSA-1632852", "R-HSA-389357", "R-RNO-9639288", "R-DME-1632852", "R-DME-165159", "R-HSA-1257604", "R-DME-389357", "R-DME-8943724", "R-DME-5628897", "R-RNO-8943724", "R-MMU-9856530", "R-DDI-165159"], "pathways": ["R-SCE-9639288:r:Amino acids regulate mTORC1", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-1632852:r:Macroautophagy", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-166208:r:mTORC1-mediated signalling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-DDI-1632852:r:Macroautophagy", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-HSA-165159:r:MTOR signalling", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-166208:r:mTORC1-mediated signalling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-MMU-1632852:r:Macroautophagy", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-1632852:r:Macroautophagy", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-CEL-165159:r:MTOR signalling", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-165159:r:MTOR signalling", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-165159:r:MTOR signalling", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-HSA-1632852:r:Macroautophagy", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-9639288:r:Amino acids 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events in G1", "R-RNO-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-1538133:r:G0 and Early G1", "R-CEL-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-DME-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 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"R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "type": "Domain"}, "IPR024600": {"description": "Notch, C-terminal", "go_ids": [], "go_terms": [], "name": "Notch_C", "pathway_ids": ["R-XTR-2979096", "R-HSA-8941856", "R-HSA-2122948", "R-RNO-9017802", "R-MMU-2122947", "R-XTR-8941856", "R-MMU-2122948", "R-HSA-9818749", "R-XTR-2122948", "R-HSA-9824272", "R-XTR-2197563", "R-XTR-1912420", "R-HSA-1912408", "R-RNO-350054", "R-MMU-1912420", "R-HSA-5083630", "R-HSA-2979096", "R-HSA-9017802", "R-HSA-9818030", "R-MMU-9013507", "R-RNO-1912420", "R-HSA-2691232", "R-HSA-9013507", "R-HSA-2122947", "R-HSA-1912420", "R-HSA-9013508", "R-HSA-210744", "R-HSA-2894862", "R-XTR-9013507", "R-RNO-9013507", "R-MMU-9017802", "R-HSA-350054", "R-HSA-9013695", "R-HSA-2644607", "R-HSA-2660826", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-1912399", "R-XTR-9017802"], "pathways": ["R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9824272:r:Somitogenesis", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-XTR-9017802:r:Noncanonical activation of NOTCH3"], "type": "Domain"}, "IPR024601": {"description": "Peptidase M1, alanyl aminopeptidase, C-terminal", "go_ids": [], "go_terms": [], "name": "Peptidase_M1_pepN_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024602": {"description": "Conserved oligomeric Golgi complex, subunit 2, N-terminal", "go_ids": [], "go_terms": [], "name": "COG_su2_N", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-CEL-6811438", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR024603": {"description": "COG complex component, COG2, C-terminal", "go_ids": [], "go_terms": [], "name": "COG_complex_COG2_C", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-CEL-6811438", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR024604": {"description": "Serine/threonine-protein kinase haspin, C-terminal", "go_ids": [], "go_terms": [], "name": "GSG2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024605": {"description": "NAD(P) transhydrogenase, alpha subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "NADP_transhyd_a_C", "pathway_ids": ["R-MMU-71403", "R-HSA-71403", "R-BTA-71403"], "pathways": ["R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Domain"}, "IPR024606": {"description": "UPF0606 protein KIAA1549, alpha/beta domain 2", "go_ids": [], "go_terms": [], "name": "KIAA1549_a/b_2", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR024608": {"description": "Smad anchor for receptor activation-like, Smad-binding 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{"description": "V(D)J recombination-activating protein 1", "go_ids": ["GO:0033151", "GO:0043565", "GO:0061630", "GO:0004519"], "go_terms": ["GO:0033151:V(D)J recombination:P", "GO:0043565:sequence-specific DNA binding:F", "GO:0061630:ubiquitin protein ligase activity:F", "GO:0004519:endonuclease activity:F"], "name": "RAG1", "pathway_ids": ["PWY-7511", "R-HSA-1266695", "R-HSA-5687128"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Family"}, "IPR024628": {"description": "Sulphotransferase Stf0, domain", "go_ids": [], "go_terms": [], "name": "Sulfotransferase_Stf0_dom", "pathway_ids": ["PWY-7746"], "pathways": ["PWY-7746:t:mycobacterial sulfolipid biosynthesis"], "type": "Domain"}, "IPR024629": {"description": "Large ribosomal subunit protein mL67", "go_ids": ["GO:0000150", "GO:0032543", "GO:0006310", "GO:0003697"], "go_terms": ["GO:0000150:DNA strand exchange activity:F", 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"R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex"], "type": "Domain"}, "IPR024640": {"description": "Toxin-antitoxin type 1 system, toxin component", "go_ids": [], "go_terms": [], "name": "Toxin-antitoxin_type_1_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024641": {"description": "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain", "go_ids": [], "go_terms": [], "name": "HRS_helical", "pathway_ids": ["R-RNO-917729", "R-MMU-182971", "R-MMU-8856828", "R-BTA-9706019", "R-DME-432720", "R-MMU-917729", "R-BTA-5689880", "R-MMU-8856825", "R-HSA-8856828", "R-HSA-5689880", "R-MMU-9706019", "R-MMU-5689880", "R-HSA-9636383", "R-HSA-9635644", "R-MMU-9013420", "R-DME-8856828", "R-RNO-8856828", "R-MMU-432720", "R-BTA-6807004", "R-DME-917729", "R-BTA-8856828", "R-BTA-9013420", 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"R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-9635644:r:Inhibition of membrane repair", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-6807004:r:Negative regulation of MET activity", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-BTA-182971:r:EGFR downregulation", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-6807004:r:Negative regulation of MET activity", "R-RNO-9013420:r:RHOU GTPase cycle", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6807004:r:Negative regulation of MET activity", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6807004:r:Negative regulation of MET activity", "R-DME-182971:r:EGFR downregulation", "R-RNO-182971:r:EGFR downregulation", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR024642": {"description": "SUZ-C domain", "go_ids": [], "go_terms": [], "name": "SUZ-C", "pathway_ids": ["R-BTA-191859", "R-MMU-191859", 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"R-GGA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-8951936:r:RUNX3 regulates p14-ARF", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-GGA-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation"], "type": "Domain"}, "IPR024645": {"description": "Mitochondrial export protein Som1", "go_ids": ["GO:0042720"], "go_terms": ["GO:0042720:mitochondrial inner membrane peptidase complex:C"], "name": "Mitochondr_Som1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024646": {"description": "Angiomotin, C-terminal", "go_ids": [], "go_terms": [], "name": "Angiomotin_C", "pathway_ids": ["R-BTA-2028269", "R-DRE-2028269", "R-MMU-2028269", "R-RNO-2028269", "R-HSA-9762292", "R-CFA-2028269", "R-MMU-9762292", "R-HSA-2028269"], "pathways": ["R-BTA-2028269:r:Signaling by Hippo", "R-DRE-2028269:r:Signaling by Hippo", "R-MMU-2028269:r:Signaling by Hippo", "R-RNO-2028269:r:Signaling by Hippo", "R-HSA-9762292:r:Regulation of CDH11 function", "R-CFA-2028269:r:Signaling by Hippo", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-2028269:r:Signaling by Hippo"], "type": "Domain"}, "IPR024647": {"description": "DNA polymerase alpha catalytic subunit, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DNA_pol_a_cat_su_N", "pathway_ids": ["R-MMU-174430", "R-RNO-68962", "R-HSA-69205", "R-SCE-69091", "R-DME-113501", "R-RNO-69183", "R-DME-68962", "R-RNO-69166", "R-SPO-69091", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-RNO-68952", "R-RNO-174411", "R-SCE-68952", "R-SPO-69166", "R-HSA-113501", "R-HSA-68952", "R-SCE-69183", "R-MMU-68962", "R-RNO-174430", "R-HSA-174430", "R-SPO-69183", "R-MMU-113501", "R-DME-69091", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-SCE-113501", "R-SCE-68962", "R-RNO-69091", "R-HSA-9710421", "R-MMU-68952", "R-RNO-113501", "R-SPO-113501", "R-SPO-68952", "R-HSA-69183", "R-SCE-69166", "R-MMU-69166", "R-SPO-68962", "R-HSA-69091", "R-MMU-174411", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-SCE-69091:r:Polymerase switching", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-DME-68962:r:Activation of the pre-replicative complex", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-SPO-69091:r:Polymerase switching", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-RNO-68952:r:DNA replication initiation", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-SCE-68952:r:DNA replication initiation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-68952:r:DNA replication initiation", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-69091:r:Polymerase switching", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-RNO-69091:r:Polymerase switching", "R-HSA-9710421:r:Defective pyroptosis", "R-MMU-68952:r:DNA replication initiation", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-68952:r:DNA replication initiation", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-69091:r:Polymerase switching", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Domain"}, "IPR024648": {"description": "Transposon Tf2-1-like domain", "go_ids": [], "go_terms": [], "name": "Tf2-1-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024650": {"description": "Peptidase A2B, Ty3 transposon peptidase", "go_ids": [], "go_terms": [], "name": "Peptidase_A2B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024651": {"description": "FAD-containing D-sorbitol dehydrogenase small subunit", "go_ids": [], "go_terms": [], "name": "FAD-SLDH_ssu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024652": {"description": "Trichodiene synthase", "go_ids": ["GO:0016838"], "go_terms": ["GO:0016838:carbon-oxygen lyase activity, acting on phosphates:F"], "name": "Trichodiene_synth", "pathway_ids": ["PWY-7711"], "pathways": ["PWY-7711:t:calonectrin biosynthesis"], "type": "Family"}, "IPR024653": {"description": "Peptidase, metallopeptidase M10/M27/M57", "go_ids": [], "go_terms": [], "name": "Peptidase_M10/M27/M57", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024654": {"description": "Calcineurin-like phosphoesterase domain, lpxH-type", "go_ids": [], "go_terms": [], "name": "Calcineurin-like_PHP_lpxH", "pathway_ids": ["R-BTA-3238698", "R-SPO-3238698", "R-MMU-3238698", "R-DDI-3238698", "R-DRE-3238698", "R-HSA-3238698", "R-SCE-3238698", "R-RNO-3238698", "R-XTR-3238698"], "pathways": ["R-BTA-3238698:r:WNT ligand biogenesis and trafficking", "R-SPO-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-DDI-3238698:r:WNT ligand biogenesis and trafficking", "R-DRE-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking", "R-SCE-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-3238698:r:WNT ligand biogenesis and trafficking", "R-XTR-3238698:r:WNT ligand biogenesis and trafficking"], "type": "Domain"}, "IPR024655": {"description": "Asl1-like, glycosyl hydrolase catalytic domain", "go_ids": [], "go_terms": [], "name": "Asl1_glyco_hydro_catalytic", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024656": {"description": "Ammonia monooxygenase, subunit A, archaeal", "go_ids": [], "go_terms": [], "name": "AmoA_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024657": {"description": "COMPASS complex Set1 subunit, N-SET domain", "go_ids": [], "go_terms": [], "name": "COMPASS_Set1_N-SET", "pathway_ids": ["R-MMU-8936459", "R-SCE-9772755", "R-MMU-3214841", "R-HSA-3214841", "R-DRE-3214841", "R-DME-8936459", "R-HSA-9772755", "R-DME-9772755", "R-HSA-8936459", "R-CEL-8936459", "R-SPO-9772755", "R-CEL-9772755", "R-MMU-9772755", "R-CEL-3214841"], "pathways": ["R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-3214841:r:PKMTs methylate histone lysines"], "type": "Domain"}, "IPR024659": {"description": "Major capsid protein Gp5", "go_ids": [], "go_terms": [], "name": "Phage_coat_Gp5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024660": {"description": "UNC-45/Cro1/She4, central domain", "go_ids": [], "go_terms": [], "name": "UCS_central_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024661": {"description": "DNA-directed RNA polymerase III, subunit Rpc31", "go_ids": ["GO:0006383"], "go_terms": ["GO:0006383:transcription by RNA polymerase III:P"], "name": "RNA_pol_III_Rpc31", "pathway_ids": ["R-HSA-76071", "R-SCE-76066", "R-SPO-76066", "R-HSA-73980", "R-HSA-76066", "R-SPO-76061", "R-MMU-76071", "R-BTA-76071", "R-MMU-76066", "R-BTA-76066", "R-BTA-76061", "R-HSA-76061", "R-HSA-1834949", "R-MMU-76061", "R-HSA-73780", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR024662": {"description": "Trafficking protein particle complex II-specific subunit 65", "go_ids": ["GO:1990071", "GO:0006891"], "go_terms": ["GO:1990071:TRAPPII protein complex:C", "GO:0006891:intra-Golgi vesicle-mediated transport:P"], "name": "Trs65", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024664": {"description": "L-arabinose isomerase, C-terminal", "go_ids": [], "go_terms": [], "name": "Ara_Isoase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024665": {"description": "Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "TSP/COMP_CC", "pathway_ids": ["R-HSA-186797", "R-RNO-216083", "R-HSA-216083", "R-DRE-186797", "R-MMU-186797", "R-HSA-3000178", "R-RNO-186797", "R-MMU-216083", "R-BTA-216083"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-DRE-186797:r:Signaling by PDGF", "R-MMU-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-216083:r:Integrin cell surface interactions", "R-BTA-216083:r:Integrin cell surface interactions"], "type": "Domain"}, "IPR024666": {"description": "HnRNP M, nuclear localisation signal", "go_ids": [], "go_terms": [], "name": "HnRNP_M_PY-NLS", "pathway_ids": ["R-HSA-72163", "R-HSA-6803529", "R-HSA-72203", "R-HSA-9770562", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR024668": {"description": "GA-binding protein alpha subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "GABP_asu_N", "pathway_ids": ["R-MMU-2151201", "R-DME-2151201", "R-HSA-2151201"], "pathways": ["R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis"], "type": "Domain"}, "IPR024670": {"description": "B-cell lymphoma 9, beta-catenin binding domain", "go_ids": [], "go_terms": [], "name": "BCL9_beta-catenin-bd_dom", "pathway_ids": ["R-MMU-201722", "R-HSA-201722", "R-HSA-3769402", "R-DME-209421", "R-DME-201722", "R-DME-209407", "R-DRE-201722"], "pathways": ["R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-209421:r:Transcription activation by ARM", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-209407:r:Transport of ARM to the nucleus", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex"], "type": "Domain"}, "IPR024671": {"description": "Autophagy-related protein 22-like", "go_ids": [], "go_terms": [], "name": "Atg22-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024672": {"description": "Agglutinin-like protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Agglutinin-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024673": {"description": "Octaheme c-type cytochrome", "go_ids": [], "go_terms": [], "name": "Octahem_Cyt_c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024674": {"description": "HpaB/PvcC/4-BUDH N-terminal", "go_ids": [], "go_terms": [], "name": "HpaB/PvcC/4-BUDH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024675": {"description": "Eukaryotic translation initiation factor 3 subunit G, N-terminal", "go_ids": [], "go_terms": [], "name": "eIF3g_N", "pathway_ids": ["R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-CEL-72695", "R-XTR-72702", "R-RNO-72689", "R-MMU-72649", "R-HSA-72695", "R-RNO-72695", "R-MMU-72706", "R-SPO-72689", "R-SCE-72695", "R-XTR-72695", "R-SCE-72702", "R-MMU-72695", "R-DRE-156827", "R-SCE-156827", "R-DME-72695", "R-MMU-72702", "R-RNO-156827", "R-DDI-72702", "R-SPO-72706", "R-SPO-72649", "R-DRE-72695", "R-SPO-72695", "R-DDI-72695", "R-XTR-156827", "R-DME-72689", "R-HSA-72706", "R-RNO-72702", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-CEL-156827", "R-RNO-72649", "R-DRE-72649", "R-SCE-72649", "R-DRE-72702", "R-DRE-72689", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-DDI-156827", "R-CEL-72689", "R-DDI-72689"], "pathways": ["R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Domain"}, "IPR024677": {"description": "4-HPA 3-monooxygenase large component/Pyoverdin chromophore biosynthetic protein", "go_ids": [], "go_terms": [], "name": "HpaB/PvcC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024678": {"description": "Serine/threonine-protein kinase OSR1/WNK, CCT domain", "go_ids": ["GO:0004674", "GO:0005524"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0005524:ATP binding:F"], "name": "Kinase_OSR1/WNK_CCT", "pathway_ids": ["R-HSA-2672351"], "pathways": ["R-HSA-2672351:r:Stimuli-sensing channels"], "type": "Domain"}, "IPR024679": {"description": "Pre-rRNA-processing protein Ipi1, N-terminal", "go_ids": [], "go_terms": [], "name": "Ipi1_N", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-DRE-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR024680": {"description": "Ribulose-1,5-bisphosphate carboxylase small subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "RuBisCO_ssu_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024681": {"description": "Ribulose bisphosphate carboxylase, small subunit", "go_ids": [], "go_terms": [], "name": "RuBisCO_ssu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024682": {"description": "Nuclear pore localisation protein Npl4, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "Npl4_Ub-like_dom", "pathway_ids": ["R-MMU-8951664", "R-HSA-9954709", "R-SPO-110320", "R-HSA-8951664", "R-RNO-8951664", "R-RNO-9755511", "R-MMU-110320", "R-DME-110320", "R-DME-8951664", "R-HSA-9918487", "R-HSA-9755511", "R-SPO-8951664", "R-MMU-9755511", "R-RNO-110320", "R-SPO-9755511", "R-HSA-110320", "R-DME-9755511"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-HSA-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-DME-110320:r:Translesion Synthesis by POLH", "R-DME-8951664:r:Neddylation", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-8951664:r:Neddylation", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-DME-9755511:r:KEAP1-NFE2L2 pathway"], "type": "Domain"}, "IPR024684": {"description": "Transcriptional activator PerC", "go_ids": [], "go_terms": [], "name": "Tscrpt_act_PerC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024685": {"description": "Adenylate cyclase class-I, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Adenylate_cyclase_1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024687": {"description": "MMS19, C-terminal", "go_ids": [], "go_terms": [], "name": "MMS19_C", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Domain"}, "IPR024688": {"description": "Maltose/galactoside acetyltransferase domain", "go_ids": ["GO:0016407"], "go_terms": ["GO:0016407:acetyltransferase activity:F"], "name": "Mac_dom", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR024689": {"description": "Proteasome beta subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "Proteasome_bsu_C", "pathway_ids": ["R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-SSC-9766229", "R-HSA-174178", "R-SSC-5689603", "R-RNO-8948751", "R-HSA-9604323", "R-MMU-8941858", "R-RNO-5668541", "R-SSC-8948751", "R-MMU-174154", "R-HSA-8951664", "R-HSA-5689880", "R-MMU-69017", "R-MMU-9020702", "R-HSA-9010553", "R-HSA-75815", "R-RNO-382556", "R-RNO-5687128", "R-MMU-8948751", "R-SSC-174184", "R-MMU-69481", "R-SSC-5687128", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-DDI-9929491", "R-MMU-5668541", "R-HSA-8854050", "R-RNO-8854050", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-RNO-450408", "R-HSA-211733", "R-SSC-8939902", "R-HSA-1234176", "R-DDI-6798695", "R-RNO-4641258", "R-MMU-68867", "R-DDI-174084", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-SSC-983168", "R-SSC-382556", "R-MMU-9932298", "R-DDI-9912633", "R-MMU-1234176", "R-RNO-5689880", "R-MMU-4641258", "R-SPO-9912633", "R-DDI-4641258", "R-RNO-8951664", "R-RNO-9954709", "R-HSA-180534", "R-SSC-8939236", "R-HSA-1236974", "R-MMU-5687128", "R-SSC-9932298", "R-RNO-5358346", "R-MMU-9766229", "R-RNO-69481", "R-DDI-187577", "R-HSA-174154", "R-RNO-6798695", "R-RNO-1234176", "R-SSC-75815", "R-SSC-6798695", "R-MMU-187577", "R-BTA-1236978", "R-DDI-382556", "R-SSC-450408", "R-HSA-5610785", "R-HSA-68949", 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proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-SSC-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-4641258:r:Degradation of DVL", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-382556:r:ABC-family proteins mediated transport", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-DDI-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-4641258:r:Degradation of DVL", "R-SPO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-4641258:r:Degradation of DVL", "R-RNO-8951664:r:Neddylation", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-SSC-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-SSC-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-SSC-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-SSC-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-SSC-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9907900:r:Proteasome assembly", "R-RNO-4641257:r:Degradation of AXIN", "R-DDI-5689603:r:UCH proteinases", "R-SSC-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-SCE-1236974:r:ER-Phagosome pathway", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SSC-9020702:r:Interleukin-1 signaling", "R-SSC-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-202424:r:Downstream TCR signaling", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-SSC-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-202424:r:Downstream TCR signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9766229:r:Degradation of CDH1", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-1236974:r:ER-Phagosome pathway", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-8951664:r:Neddylation", "R-SSC-4641257:r:Degradation of AXIN", "R-SSC-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-8951664:r:Neddylation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-5632684:r:Hedgehog 'on' state", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-SSC-68867:r:Assembly of the pre-replicative complex", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-SSC-69481:r:G2/M Checkpoints", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-69481:r:G2/M Checkpoints", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor 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"R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5689603:r:UCH proteinases", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-1236974:r:ER-Phagosome pathway", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SSC-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-8951664:r:Neddylation", "R-RNO-1236974:r:ER-Phagosome pathway", 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"PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", 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"PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin 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"PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR024710": {"description": "Tyramine--L-glutamate ligase", "go_ids": [], "go_terms": [], "name": "MfnD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024711": {"description": "Catalase, mono-functional, haem-containing, clades 1 and 3", "go_ids": ["GO:0006979", "GO:0004096", "GO:0020037"], "go_terms": ["GO:0006979:response to oxidative stress:P", "GO:0004096:catalase activity:F", "GO:0020037:heme binding:F"], "name": "Catalase_clade1/3", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-HSA-3299685", "R-SPO-6798695", "R-DRE-3299685", "R-CFA-9033241", "R-DME-6798695", "R-DME-9033241", "R-SCE-6798695", "R-HSA-9841251", "R-BTA-6798695", "R-MMU-9033241", "R-MMU-3299685", "R-RNO-3299685", "R-BTA-9033241", "R-DDI-3299685", "R-RNO-9033241", "R-SCE-3299685", "R-SPO-9033241", "R-HSA-9615017", "R-BTA-3299685", "R-SPO-3299685", "R-DRE-6798695", "R-CFA-3299685", "R-SCE-9033241", "R-MMU-6798695", "R-CFA-6798695", "R-DME-3299685", "R-DDI-9033241", "R-HSA-9033241", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-3299685:r:Detoxification of Reactive Oxygen Species", "R-CFA-9033241:r:Peroxisomal protein import", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-9033241:r:Peroxisomal protein import", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-9033241:r:Peroxisomal protein import", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-9033241:r:Peroxisomal protein import", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-DRE-6798695:r:Neutrophil degranulation", "R-CFA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SCE-9033241:r:Peroxisomal protein import", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-6798695:r:Neutrophil degranulation", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR024712": {"description": "Catalase, mono-functional, haem-containing, clade 2", "go_ids": ["GO:0006979", "GO:0004096", "GO:0020037"], "go_terms": ["GO:0006979:response to oxidative stress:P", "GO:0004096:catalase activity:F", "GO:0020037:heme binding:F"], "name": "Catalase_clade2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024713": {"description": "Fructosamine deglycase FrlB", "go_ids": [], "go_terms": [], "name": "Fructosamine_deglycase_FrlB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024715": {"description": "Coagulation factor 5/8-like", "go_ids": [], "go_terms": [], "name": "Factor_5/8-like", "pathway_ids": ["R-MMU-204005", "R-HSA-9672383", "R-HSA-9672396", "R-HSA-9674519", "R-MMU-5694530", "R-HSA-140837", "R-HSA-9672397", "R-RNO-917937", "R-HSA-9673202", "R-MMU-163841", "R-MMU-140837", "R-MMU-425410", "R-HSA-140875", "R-MMU-8957275", "R-HSA-5694530", "R-HSA-163841", "R-MMU-140875", "R-HSA-204005", "R-RNO-381426", "R-HSA-114608", "R-MMU-114608", "R-MMU-917937", "R-RNO-425410", "R-RNO-8957275", "R-MMU-381426", "R-HSA-9672387", "R-HSA-9672391", "R-HSA-8957275", "R-HSA-381426", "R-HSA-9672395", "R-HSA-9672393"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-9672383:r:Defective factor IX causes thrombophilia", "R-HSA-9672396:r:Defective cofactor function of FVIIIa variant", "R-HSA-9674519:r:Defective F8 sulfation at Y1699", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9672397:r:Defective F8 secretion", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-9673202:r:Defective F9 variant does not activate FX", "R-MMU-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-425410:r:Metal ion SLC transporters", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation", "R-MMU-917937:r:Iron uptake and transport", "R-RNO-425410:r:Metal ion SLC transporters", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9672387:r:Defective F8 accelerates dissociation of the A2 domain", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9672395:r:Defective F8 binding to the cell membrane", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor"], "type": "Family"}, "IPR024717": {"description": "Denitrification system component NapC/NirT/NrfH", "go_ids": ["GO:0019333", "GO:0016020", "GO:0020037"], "go_terms": ["GO:0019333:denitrification pathway:P", "GO:0016020:membrane:C", "GO:0020037:heme binding:F"], "name": "NapC/NirT/NrfH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024719": {"description": "HpaB/PvcC/4-BUDH C-terminal", "go_ids": [], "go_terms": [], "name": "HpaB/PvcC/4-BUDH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024721": {"description": "Snurportin-1, N-terminal", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Snurportin-1_N", "pathway_ids": ["R-BTA-191859", "R-RNO-191859", "R-HSA-191859", "R-MMU-191859", "R-GGA-191859"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-RNO-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly", "R-MMU-191859:r:snRNP Assembly", "R-GGA-191859:r:snRNP Assembly"], "type": "Domain"}, "IPR024723": {"description": "Termicin", "go_ids": [], "go_terms": [], "name": "Termicin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024724": {"description": "Molybdenum cofactor biosynthesis protein F, N-terminal", "go_ids": [], "go_terms": [], "name": "MoaF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024725": {"description": "E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain", "go_ids": ["GO:0043130"], "go_terms": ["GO:0043130:ubiquitin binding:F"], "name": "UBR5_UBA", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR024726": {"description": "Ferric siderophore reductase, C-terminal", "go_ids": ["GO:0051537"], "go_terms": ["GO:0051537:2 iron, 2 sulfur cluster binding:F"], "name": "FhuF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024727": {"description": "NAD-glutamate dehydrogenase, N-terminal ACT1 domain", "go_ids": [], "go_terms": [], "name": "NAD_Glu_DH_N_ACT1", "pathway_ids": ["PWY-6728", "PWY-5022", "PWY-7126", "PWY-8190"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-7126:t:ethene biosynthesis IV (engineered)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)"], "type": "Domain"}, "IPR024728": {"description": "DNA polymerase type-Y, HhH motif", "go_ids": [], "go_terms": [], "name": "PolY_HhH_motif", "pathway_ids": ["R-MMU-5655862", "R-HSA-5685942", "R-MMU-6782135", "R-CEL-6782135", "R-HSA-5696397", "R-CEL-5655862", "R-HSA-6782210", "R-MMU-5656169", "R-HSA-5696400", "R-MMU-6782210", "R-HSA-6782135", "R-MMU-5685942", "R-CEL-6782210", "R-MMU-5696397", "R-HSA-5656169", "R-CEL-5696397", "R-HSA-5655862", "R-MMU-5696400"], "pathways": ["R-MMU-5655862:r:Translesion synthesis by POLK", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-MMU-5696400:r:Dual Incision in GG-NER"], "type": "Conserved_site"}, "IPR024729": {"description": "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain", "go_ids": [], "go_terms": [], "name": "USP7_ICP0-binding_dom", "pathway_ids": ["R-RNO-6781823", "R-CEL-8948747", "R-DME-6804757", "R-HSA-6781827", "R-MMU-6782135", "R-DME-6781823", "R-HSA-5689880", "R-RNO-8866652", "R-MMU-8866652", "R-HSA-6781823", "R-DME-8866652", "R-MMU-5689880", "R-MMU-6781823", "R-HSA-8866652", "R-HSA-6804757", "R-DME-8948747", "R-HSA-6782210", "R-SCE-6782210", "R-DME-6782135", "R-RNO-8948747", "R-RNO-6782210", "R-HSA-8948747", "R-RNO-6782135", "R-MMU-6804757", "R-MMU-8948747", "R-HSA-6782135", "R-CEL-6782210", "R-RNO-5689880", "R-CEL-6781823", "R-CEL-5689880", "R-RNO-6804757", "R-SPO-6782210", "R-CEL-6782135", "R-MMU-6782210", "R-DME-6782210", "R-SPO-6782135", "R-DME-5689880", "R-SCE-6782135"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-8948747:r:Regulation of PTEN localization", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DME-8948747:r:Regulation of PTEN localization", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782135:r:Dual incision in TC-NER", "R-RNO-8948747:r:Regulation of PTEN localization", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-8948747:r:Regulation of PTEN localization", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-5689880:r:Ub-specific processing proteases", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-5689880:r:Ub-specific processing proteases", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Domain"}, "IPR024730": {"description": "Merozoite surface protein, EGF domain 1", "go_ids": [], "go_terms": [], "name": "MSP1_EGF_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024731": {"description": "NELL2-like, EGF domain", "go_ids": [], "go_terms": [], "name": "NELL2-like_EGF", "pathway_ids": ["R-HSA-8964011", "R-HSA-186797", "R-HSA-3000497", "R-HSA-3000157", "R-MMU-3000497", "R-HSA-1566948", "R-BTA-2173789", "R-CEL-1566948", "R-MMU-8957275", "R-BTA-8957275", "R-HSA-196791", "R-CEL-1474228", "R-CEL-2129379", "R-HSA-5362798", "R-RNO-9758881", "R-HSA-2142845", "R-MMU-381426", "R-BTA-381426", "R-HSA-3359463", "R-MMU-186797", "R-CEL-381426", "R-HSA-3359462", "R-CEL-8957275", "R-MMU-1566948", "R-BTA-2129379", "R-HSA-381426", "R-HSA-2173789", "R-MMU-446203", "R-MMU-1474228", "R-HSA-1474228", "R-CEL-216083", "R-MMU-3000157", "R-HSA-2129379", "R-HSA-216083", "R-HSA-446203", "R-BTA-1566948", "R-MMU-2173789", "R-HSA-5083635", "R-BTA-1474228", "R-HSA-9830364", "R-HSA-428542", "R-RNO-446203", "R-MMU-2160916", "R-MMU-2142845", "R-RNO-8964011", "R-DRE-5362798", "R-HSA-2160916", "R-HSA-9830674", "R-RNO-196791", "R-HSA-5173214", "R-MMU-5362798", "R-MMU-5173214", "R-MMU-216083", "R-HSA-8957275", "R-HSA-9758881", "R-CEL-2173789", "R-BTA-216083", "R-MMU-2129379"], "pathways": ["R-HSA-8964011:r:HDL clearance", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-3000157:r:Laminin interactions", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-1566948:r:Elastic fibre formation", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-1566948:r:Elastic fibre formation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-2142845:r:Hyaluronan metabolism", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3359463:r:Defective CUBN causes MGA1", "R-MMU-186797:r:Signaling by PDGF", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3359462:r:Defective AMN causes MGA1", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-MMU-1566948:r:Elastic fibre formation", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-CEL-216083:r:Integrin cell surface interactions", "R-MMU-3000157:r:Laminin interactions", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-BTA-1566948:r:Elastic fibre formation", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-RNO-446203:r:Asparagine N-linked glycosylation", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-RNO-8964011:r:HDL clearance", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-2160916:r:Hyaluronan degradation", "R-HSA-9830674:r:Formation of the ureteric bud", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-216083:r:Integrin cell surface interactions", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR024732": {"description": "Alpha-N-acetylglucosaminidase, C-terminal", "go_ids": [], "go_terms": [], "name": "NAGLU_C", "pathway_ids": ["R-HSA-2206282", "R-HSA-2024096"], "pathways": ["R-HSA-2206282:r:MPS IIIB - Sanfilippo syndrome B", "R-HSA-2024096:r:HS-GAG degradation"], "type": "Domain"}, "IPR024733": {"description": "Alpha-N-acetylglucosaminidase, tim-barrel domain", "go_ids": [], "go_terms": [], "name": "NAGLU_tim-barrel", "pathway_ids": ["R-HSA-2206282", "R-HSA-2024096"], "pathways": ["R-HSA-2206282:r:MPS IIIB - Sanfilippo syndrome B", "R-HSA-2024096:r:HS-GAG degradation"], "type": "Domain"}, "IPR024735": {"description": "Conjugative transposon protein TcpC", "go_ids": [], "go_terms": [], "name": "TcpC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024736": {"description": "Oestrogen-type nuclear receptor final C-terminal domain", "go_ids": [], "go_terms": [], "name": "Oestrogen-typ_rcpt_final_C_dom", "pathway_ids": ["R-SSC-1257604", "R-SSC-1251985", "R-SSC-5689896", "R-HSA-8939256", "R-BTA-8939211", "R-HSA-5689896", "R-MMU-6811558", "R-HSA-1251985", "R-RNO-1257604", "R-RNO-9009391", "R-MMU-9009391", "R-RNO-9841251", "R-BTA-8866910", "R-HSA-9927418", "R-RNO-9018519", "R-MMU-5689896", "R-SSC-9009391", "R-SSC-6811558", "R-BTA-9018519", "R-SSC-8866910", "R-BTA-4090294", "R-MMU-383280", "R-SSC-8939211", "R-RNO-6811558", "R-SSC-383280", "R-HSA-8939211", "R-BTA-6811558", "R-HSA-8866910", "R-BTA-1251985", "R-HSA-4090294", "R-MMU-4090294", "R-RNO-4090294", "R-RNO-1251985", "R-RNO-383280", "R-HSA-9018519", "R-RNO-8866910", "R-MMU-8931987", "R-HSA-8931987", "R-MMU-8939211", "R-BTA-5689896", "R-SSC-4090294", "R-RNO-8931987", "R-HSA-9841251", "R-SSC-8931987", "R-HSA-2219530", "R-MMU-1257604", "R-SSC-9018519", "R-BTA-9009391", "R-MMU-9018519", "R-HSA-6811558", "R-HSA-8939902", "R-MMU-8866910", "R-MMU-1251985", "R-HSA-9009391", "R-HSA-383280", "R-BTA-8931987", "R-BTA-383280", "R-MMU-9841251", "R-SSC-9841251", "R-BTA-1257604", "R-RNO-5689896", "R-HSA-1257604", "R-BTA-9841251", "R-RNO-8939211", "R-HSA-9927426"], "pathways": ["R-SSC-1257604:r:PIP3 activates AKT signaling", "R-SSC-1251985:r:Nuclear signaling by ERBB4", "R-SSC-5689896:r:Ovarian tumor domain proteases", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-BTA-8939211:r:ESR-mediated signaling", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-SSC-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SSC-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-4090294:r:SUMOylation of intracellular receptors", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-SSC-8939211:r:ESR-mediated signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-383280:r:Nuclear Receptor transcription pathway", "R-HSA-8939211:r:ESR-mediated signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-RNO-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-MMU-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-8939211:r:ESR-mediated signaling", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-SSC-4090294:r:SUMOylation of intracellular receptors", "R-RNO-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SSC-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SSC-9018519:r:Estrogen-dependent gene expression", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-BTA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-BTA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SSC-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-8939211:r:ESR-mediated signaling", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Domain"}, "IPR024737": {"description": "Get5, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Get5_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024738": {"description": "Transcriptional coactivator Hfi1/Transcriptional adapter 1", "go_ids": ["GO:0070461"], "go_terms": ["GO:0070461:SAGA-type complex:C"], "name": "Hfi1/Tada1", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR024739": {"description": "Protein tyrosine phosphatase, receptor type, N-terminal", "go_ids": [], "go_terms": [], "name": "PTP_recept_N", "pathway_ids": ["R-HSA-6798695", "R-HSA-202427", "R-HSA-416700", "R-RNO-202427", "R-RNO-416700", "R-MMU-202427", "R-MMU-6798695", "R-MMU-416700", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-416700:r:Other semaphorin interactions", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-416700:r:Other semaphorin interactions", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR024740": {"description": "Hen1, N-terminal", "go_ids": [], "go_terms": [], "name": "Hen1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024741": {"description": "Condensin-2 complex subunit G2", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "Condensin2_G2", "pathway_ids": ["R-MMU-2299718", "R-DRE-2299718", "R-HSA-2299718"], "pathways": ["R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-DRE-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-2299718:r:Condensation of Prophase Chromosomes"], "type": "Family"}, "IPR024742": {"description": "Glycogen debranching enzyme, bacterial and archaeal type, N-terminal", "go_ids": [], "go_terms": [], "name": "Glycogen_debranch_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024743": {"description": "Dynein heavy chain, coiled coil stalk", "go_ids": [], "go_terms": [], "name": "Dynein_HC_stalk", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic 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the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR024744": {"description": "Putative cyclic diguanylate phosphodiesterase, CSS motif-containing domain", "go_ids": [], "go_terms": [], "name": "CSS-motif_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024745": {"description": "Glycoside hydrolase, family 44, catalytic domain", "go_ids": [], "go_terms": [], "name": "GH44_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024746": {"description": "Glycosyl hydrolase family 100", "go_ids": ["GO:0033926"], "go_terms": ["GO:0033926:endo-alpha-N-acetylgalactosaminidase activity:F"], "name": "Glyco_hydro_100", "pathway_ids": ["PWY-8314"], "pathways": ["PWY-8314:t:inulin degradation"], "type": "Family"}, "IPR024747": {"description": "Pyridoxamine 5'-phosphate oxidase-related", "go_ids": [], "go_terms": [], "name": "Pyridox_Oxase-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024749": {"description": "Putative collagen-binding domain", "go_ids": [], "go_terms": [], "name": "Collagen-bd_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024750": {"description": "Calcium-transporting P-type ATPase, N-terminal autoinhibitory domain", "go_ids": ["GO:0005516"], "go_terms": ["GO:0005516:calmodulin binding:F"], "name": "Ca_ATPase_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024751": {"description": "Variant erythrocyte surface antigen-1", "go_ids": [], "go_terms": [], "name": "VESA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024752": {"description": "Myb/SANT-like domain", "go_ids": [], "go_terms": [], "name": "Myb/SANT-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024753": {"description": "Regulatory protein AriR", "go_ids": ["GO:0071468"], "go_terms": ["GO:0071468:cellular response to acidic pH:P"], "name": "AriR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024754": {"description": "DNA polymerase III PolC-like, N-terminal domain II", "go_ids": [], "go_terms": [], "name": "DNA_PolC-like_N_II", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024755": {"description": "Circularly permutated YpsA SLOG", "go_ids": [], "go_terms": [], "name": "cpYpsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024756": {"description": "Protocatechuate 3,4-dioxygenase beta subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "PCDO_beta_N", "pathway_ids": ["PWY-6041"], "pathways": ["PWY-6041:t:4-sulfocatechol degradation"], "type": "Domain"}, "IPR024757": {"description": "Cell division protein FtsZ, C-terminal", "go_ids": [], "go_terms": [], "name": "FtsZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024758": {"description": "Inheritance of peroxisomes protein 1", "go_ids": ["GO:0045033", "GO:0005780"], "go_terms": ["GO:0045033:peroxisome inheritance:P", "GO:0005780:extrinsic component of intraperoxisomal membrane:C"], "name": "Inp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024759": {"description": "UvrB, YAD/RRR-motif-containing domain", "go_ids": [], "go_terms": [], "name": "UvrB_YAD/RRR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024760": {"description": "Helix-turn-helix, conjugative transposon-like", "go_ids": [], "go_terms": [], "name": "HTH_dom_conjug_TS-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024761": {"description": "Transcription factor IIIC, 90kDa subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "TFIIIC_delta_N", "pathway_ids": ["R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-HSA-76061", "R-SPO-76066", "R-HSA-76066", "R-MMU-76061"], "pathways": ["R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR024763": {"description": "Vacuolar protein sorting protein 11, C-terminal", "go_ids": [], "go_terms": [], "name": "VPS11_C", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR024764": {"description": "Transcription factor IIIC, putative zinc-finger", "go_ids": [], "go_terms": [], "name": "TFIIIC_Znf", "pathway_ids": ["R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-HSA-76061", "R-SPO-76066", "R-HSA-76066", "R-MMU-76061"], "pathways": ["R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR024765": {"description": "TOBE-like domain", "go_ids": [], "go_terms": [], "name": "TOBE-like", "pathway_ids": ["R-MTU-936635"], "pathways": ["R-MTU-936635:r:Sulfate assimilation"], "type": "Domain"}, "IPR024766": {"description": "Zinc finger, RING-H2-type", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_RING_H2", "pathway_ids": ["PWY-7511", "R-DDI-8854050", "R-DME-110314", "R-HSA-9020702", "R-MMU-5632684", "R-HSA-9604323", "R-CEL-5632684", "R-HSA-8951664", "R-DME-6781823", "R-HSA-9010553", "R-HSA-9932298", "R-DME-8951664", "R-MMU-9020702", "R-CEL-195253", "R-DDI-6782210", "R-DME-5696394", "R-HSA-6781823", "R-DDI-5632684", "R-MMU-110314", "R-MMU-8951664", "R-DDI-8951664", "R-SPO-5696395", "R-MMU-5696395", "R-CEL-110314", "R-CEL-1234176", "R-DME-8939902", "R-DDI-9929491", "R-MMU-9929491", "R-HSA-8854050", "R-MMU-9929356", "R-MMU-5696394", "R-CEL-5696394", "R-HSA-5610783", "R-HSA-2122947", "R-DME-6782135", "R-HSA-9708530", "R-HSA-1234176", "R-DME-9762114", "R-HSA-9929491", "R-HSA-1170546", "R-CEL-4641258", "R-DDI-5658442", "R-DME-209461", "R-DDI-6781823", "R-HSA-9755511", "R-CEL-6782210", "R-HSA-4641258", "R-MMU-1234176", "R-CEL-9929491", "R-MMU-9705462", "R-MMU-9708530", "R-CEL-6781823", "R-HSA-180585", "R-DME-9755511", "R-MMU-4641258", "R-HSA-5658442", "R-HSA-2644607", "R-DDI-5696394", "R-DDI-4641258", "R-SPO-110314", "R-HSA-5696395", "R-CEL-6782135", "R-HSA-5696394", "R-CEL-5696395", "R-DDI-68949", "R-DME-5610785", "R-SPO-8951664", "R-HSA-2644606", "R-MMU-6782210", "R-DME-69601", "R-DME-1234176", "R-HSA-110314", "R-SCE-6782135", "R-HSA-9833109", "R-DDI-6782135", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-MMU-5610780", "R-DDI-5696395", "R-HSA-6781827", "R-DDI-9755511", "R-MMU-6782135", "R-DME-9954709", "R-SCE-8854050", "R-DME-5610780", "R-MMU-68949", "R-CEL-8939902", "R-DME-4641258", "R-MMU-9755511", "R-MMU-9954709", "R-CEL-983168", "R-DME-195253", "R-MMU-69601", "R-CEL-8854050", "R-MMU-6781823", "R-MMU-5610785", "R-HSA-9954709", "R-DDI-69601", "R-MMU-8854050", "R-SPO-983168", "R-HSA-6782210", "R-MMU-5658442", "R-DME-216167", "R-DME-9929491", "R-MMU-9762114", "R-SCE-983168", "R-HSA-9762114", "R-SCE-6782210", "R-MMU-195253", "R-MMU-5696400", "R-DME-68949", "R-HSA-195253", "R-HSA-5610780", "R-DME-209360", "R-MMU-1170546", "R-CEL-9954709", "R-CEL-9755511", "R-HSA-2894862", "R-HSA-6782135", "R-HSA-9679191", "R-HSA-983168", "R-HSA-69601", "R-DME-5696395", "R-HSA-5632684", "R-DME-8854050", "R-HSA-8939902", "R-DDI-983168", "R-HSA-9725371", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-DME-5632684", "R-SPO-5696400", "R-MMU-8939902", "R-DME-5696400", "R-SPO-6782210", "R-HSA-9705462", "R-MMU-983168", "R-HSA-5696400", "R-DME-9020702", "R-DME-6782210", "R-SPO-6782135", "R-CEL-8951664", "R-CEL-9762114", "R-SPO-8854050"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-8951664:r:Neddylation", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5632684:r:Hedgehog 'on' state", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1170546:r:Prolactin receptor signaling", "R-CEL-4641258:r:Degradation of DVL", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-4641258:r:Degradation of DVL", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-4641258:r:Degradation of DVL", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-DME-216167:r:Nuclear CI is degraded", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-68949:r:Orc1 removal from chromatin", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5632684:r:Hedgehog 'on' state", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-9020702:r:Interleukin-1 signaling", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-8951664:r:Neddylation", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "type": "Domain"}, "IPR024767": {"description": "Pre-mRNA-splicing factor 38, C-terminal", "go_ids": [], "go_terms": [], "name": "PRP38_C", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR024768": {"description": "Meiosis regulator and mRNA stability factor 1", "go_ids": ["GO:0005777", "GO:0010468"], "go_terms": ["GO:0005777:peroxisome:C", "GO:0010468:regulation of gene expression:P"], "name": "Marf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024769": {"description": "TcdA/TcdB toxin, pore forming domain", "go_ids": [], "go_terms": [], "name": "TcdA/TcdB_pore_forming", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR024770": {"description": "TcdA/TcdB toxin, catalytic glycosyltransferase domain", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "TcdA/TcdB_cat", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR024771": {"description": "SUZ domain", "go_ids": [], "go_terms": [], "name": "SUZ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024772": {"description": "TcdA/TcdB toxin, N-terminal helical domain", "go_ids": [], "go_terms": [], "name": "TcdA/TcdB_N", "pathway_ids": ["PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161"], "pathways": ["PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism"], "type": "Domain"}, "IPR024774": {"description": "Pleckstrin homology domain, Mcp5-type", "go_ids": ["GO:0005543", "GO:0032065", "GO:0005938", "GO:0005515"], "go_terms": ["GO:0005543:phospholipid binding:F", "GO:0032065:maintenance of protein location in cell cortex:P", "GO:0005938:cell cortex:C", "GO:0005515:protein binding:F"], "name": "PH_dom-Mcp5-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024775": {"description": "Hercynine oxygenase, DinB-like domain", "go_ids": [], "go_terms": [], "name": "EgtB_DinB-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024778": {"description": "Putative cellulase", "go_ids": [], "go_terms": [], "name": "Put_cellulase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024779": {"description": "2OGFeDO JBP1/TET, oxygenase domain", "go_ids": [], "go_terms": [], "name": "2OGFeDO_JBP1/TET_oxygenase_dom", "pathway_ids": ["R-HSA-9821002", "R-HSA-5221030", "R-HSA-9827857"], "pathways": ["R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-5221030:r:TET1,2,3 and TDG demethylate DNA", "R-HSA-9827857:r:Specification of primordial germ cells"], "type": "Domain"}, "IPR024781": {"description": "Merozoite surface protein, C-terminal", "go_ids": [], "go_terms": [], "name": "MSP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024783": {"description": "Transducer of regulated CREB activity, N-terminal", "go_ids": ["GO:0008140", "GO:0051289"], "go_terms": ["GO:0008140:cAMP response element binding protein binding:F", "GO:0051289:protein homotetramerization:P"], "name": "TORC_N", "pathway_ids": ["R-HSA-9931510", "R-HSA-9707616", "R-HSA-2151201", "R-HSA-9931509"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9707616:r:Heme signaling", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2"], "type": "Domain"}, "IPR024784": {"description": "Transducer of regulated CREB activity, middle domain", "go_ids": [], "go_terms": [], "name": "TORC_M", "pathway_ids": ["R-HSA-9931510", "R-HSA-9707616", "R-HSA-2151201", "R-HSA-9931509"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9707616:r:Heme signaling", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2"], "type": "Domain"}, "IPR024785": {"description": "Transducer of regulated CREB activity, C-terminal", "go_ids": [], "go_terms": [], "name": "TORC_C", "pathway_ids": ["R-HSA-9931510", "R-HSA-9707616", "R-HSA-2151201", "R-HSA-9931509"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9707616:r:Heme signaling", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2"], "type": "Domain"}, "IPR024786": {"description": "CREB-regulated transcription coactivator", "go_ids": ["GO:0005634", "GO:0005737"], "go_terms": ["GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C"], "name": "TORC", "pathway_ids": ["R-HSA-9931510", "R-HSA-9707616", "R-HSA-2151201", "R-HSA-9931509"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9707616:r:Heme signaling", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2"], "type": "Family"}, "IPR024787": {"description": "EcsC protein", "go_ids": [], "go_terms": [], "name": "EcsC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024788": {"description": "Malectin-like domain", "go_ids": [], "go_terms": [], "name": "Malectin-like_Carb-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024789": {"description": "Anaphase-promoting complex subunit 4", "go_ids": ["GO:0005680", "GO:0031145"], "go_terms": ["GO:0005680:anaphase-promoting complex:C", "GO:0031145:anaphase-promoting complex-dependent catabolic process:P"], "name": "APC4", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-SPO-176408", "R-HSA-2467813", "R-MMU-174154", "R-MMU-2467813", "R-MMU-179409", "R-MMU-69017", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-CEL-983168", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-DDI-176409", "R-DDI-2559582", "R-SPO-983168", "R-DDI-2467813", "R-DDI-176412", "R-SCE-983168", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-176409", "R-DDI-174084", "R-MMU-68867", "R-SPO-2559582", "R-HSA-176409", "R-HSA-9687136", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-SPO-179409", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-DDI-174184", "R-MMU-141430", "R-HSA-69017", "R-DDI-141430", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-DDI-174178", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Family"}, "IPR024790": {"description": "Anaphase-promoting complex subunit 4, long domain", "go_ids": [], "go_terms": [], "name": "APC4_long_dom", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-SPO-176408", "R-HSA-2467813", "R-MMU-174154", "R-MMU-2467813", "R-MMU-179409", "R-MMU-69017", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-DDI-176409", "R-DDI-2559582", "R-SPO-983168", "R-DDI-2467813", "R-DDI-176412", "R-SCE-983168", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-176409", "R-DDI-174084", "R-MMU-68867", "R-SPO-2559582", "R-HSA-176409", "R-HSA-9687136", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-SPO-179409", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-DDI-174184", "R-MMU-141430", "R-HSA-69017", "R-DDI-141430", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-DDI-174178", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Domain"}, "IPR024791": {"description": "Cytochrome c oxidase subunit III", "go_ids": ["GO:0016020", "GO:0019646", "GO:0009055"], "go_terms": ["GO:0016020:membrane:C", "GO:0019646:aerobic electron transport chain:P", "GO:0009055:electron transfer activity:F"], "name": "Cyt_c/ubiquinol_Oxase_su3", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279", "R-SSC-611105", "R-GGA-9707564", "R-HSA-5419276", "R-SSC-5419276", "R-DRE-611105", "R-DME-9707564", "R-SSC-5628897", "R-DRE-9864848", "R-RNO-5628897", "R-SSC-9864848", "R-RNO-9707564", "R-HSA-5628897", "R-DME-611105", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-GGA-5419276", "R-DME-9864848", "R-SSC-9707564", "R-RNO-5419276", "R-GGA-5628897", "R-HSA-9707564", "R-GGA-611105", "R-MMU-611105", "R-MMU-5628897", "R-MMU-5419276", "R-DME-5419276", "R-MMU-9864848", "R-CEL-5419276", "R-DRE-9707564", "R-DRE-5628897", "R-DME-5628897", "R-MMU-9707564", "R-DRE-5419276"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "R-SSC-611105:r:Respiratory electron transport", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-DRE-611105:r:Respiratory electron transport", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-611105:r:Respiratory electron transport", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-DME-9864848:r:Complex IV assembly", "R-SSC-9707564:r:Cytoprotection by HMOX1", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-GGA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-MMU-9864848:r:Complex IV assembly", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR024792": {"description": "Rho GDP-dissociation inhibitor domain superfamily", "go_ids": [], "go_terms": [], "name": "RhoGDI_dom_sf", "pathway_ids": ["R-SCE-9013423", "R-CEL-8980692", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-9013106", "R-MMU-9013148", "R-MMU-9013404", "R-BTA-9013148", "R-DDI-9013149", "R-CEL-9013149", "R-SPO-9013106", "R-HSA-9013423", "R-CEL-9013407", "R-SCE-8980692", "R-SCE-9013149", "R-HSA-9013148", "R-RNO-9013404", "R-RNO-9013106", "R-HSA-9013408", "R-RNO-9013408", "R-DDI-9013423", "R-CEL-9013148", "R-MMU-193634", "R-CEL-9013423", "R-BTA-9013407", "R-MMU-9013407", "R-RNO-9013407", "R-RNO-9013148", "R-SPO-9013148", "R-RNO-193634", "R-MMU-209563", "R-RNO-209563", "R-SCE-9013106", "R-HSA-209563", "R-SPO-8980692", "R-HSA-9013404", "R-HSA-9013149", "R-BTA-9013408", "R-HSA-193634", "R-HSA-8980692", "R-SCE-9013148", "R-MMU-9013423", "R-MMU-9013026", "R-HSA-9013026", "R-DDI-9013404", "R-MMU-9013149", "R-HSA-9013407"], "pathways": ["R-SCE-9013423:r:RAC3 GTPase cycle", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-209563:r:Axonal growth stimulation", "R-RNO-209563:r:Axonal growth stimulation", "R-SCE-9013106:r:RHOC GTPase cycle", "R-HSA-209563:r:Axonal growth stimulation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Homologous_superfamily"}, "IPR024793": {"description": "Thrombin inhibitor hirudin", "go_ids": ["GO:0004867"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F"], "name": "Hirudin", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024794": {"description": "Large ribosomal subunit protein eL15 core domain superfamily", "go_ids": ["GO:0003735", "GO:0005840"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C"], "name": "Rbsml_eL15_core_dom_sf", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-CFA-1799339", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-CFA-72706", "R-DDI-9954714", "R-CEL-72706", "R-CFA-9954709", "R-CEL-9954716", "R-CEL-9954714", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-BTA-156827", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CFA-6791226", "R-CEL-156827", "R-CFA-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-CEL-72689", "R-CFA-9954714", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-CFA-975957", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-CFA-72689", "R-SCE-72689", "R-MMU-975956", "R-CFA-9954716", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-CFA-975956", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger 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synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-CFA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CFA-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 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"Homologous_superfamily"}, "IPR024796": {"description": "T4 endonuclease V", "go_ids": [], "go_terms": [], "name": "T4_endonuc_V", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR024810": {"description": "MAB21L/Cyclic GMP-AMP synthase-like receptor", "go_ids": [], "go_terms": [], "name": "MAB21L/cGLR", "pathway_ids": ["R-HSA-9937383", "R-RNO-9937383", "R-MMU-9937383", "R-DRE-9937383", "R-HSA-9920588", "R-HSA-1834941"], "pathways": ["R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-1834941:r:STING mediated induction of host immune responses"], "type": "Family"}, "IPR024811": {"description": "Polycomb protein ASX/ASX-like", "go_ids": [], "go_terms": [], "name": "ASX/ASX-like", "pathway_ids": ["R-HSA-5689603", "R-MMU-5689603", "R-DME-5689603"], "pathways": ["R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases"], "type": "Family"}, "IPR024812": {"description": "Tetratricopeptide repeat protein 24", "go_ids": [], "go_terms": [], "name": "TPR_24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024822": {"description": "Coilin", "go_ids": [], "go_terms": [], "name": "Coilin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024824": {"description": "Growth arrest and DNA damage-inducible protein GADD45", "go_ids": ["GO:0051726", "GO:0005634"], "go_terms": ["GO:0051726:regulation of cell cycle:P", "GO:0005634:nucleus:C"], "name": "GADD45", "pathway_ids": ["R-BTA-6804114", "R-RNO-6804114", "R-HSA-9617828", "R-MMU-6804114", "R-HSA-6804114"], "pathways": ["R-BTA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "type": "Family"}, "IPR024826": {"description": "DNA polymerase delta/II small subunit family", "go_ids": [], "go_terms": [], "name": "DNA_pol_delta/II_ssu", "pathway_ids": ["R-BTA-174411", "R-BTA-5358606", "R-CEL-69091", "R-RNO-174437", "R-HSA-174414", "R-SPO-5656169", "R-MMU-174417", "R-HSA-5696397", "R-CEL-69166", "R-RNO-110314", "R-MMU-110314", "R-RNO-69183", "R-HSA-174417", "R-CEL-110314", "R-MMU-174414", "R-RNO-5696397", "R-SPO-69091", "R-DME-69183", "R-MMU-174437", "R-BTA-5696397", "R-RNO-5656169", "R-BTA-110314", "R-MMU-5358606", "R-BTA-69183", "R-MMU-5358565", "R-SPO-69166", "R-RNO-6782210", "R-SCE-69183", "R-MMU-5651801", "R-BTA-6782135", "R-CEL-6782210", "R-MMU-69183", "R-CEL-6782135", "R-SPO-110314", "R-SCE-69166", "R-BTA-6782210", "R-MMU-6782210", "R-CEL-5651801", "R-MMU-5696397", "R-MMU-174411", "R-HSA-110314", "R-SPO-5651801", "R-RNO-174414", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-5358606", "R-BTA-174437", "R-BTA-174417", "R-RNO-69166", "R-CEL-69183", "R-BTA-5651801", "R-BTA-69166", "R-HSA-6782210", "R-CEL-5656169", "R-BTA-5656169", "R-BTA-5696400", "R-HSA-5656169", "R-RNO-174411", "R-MMU-5696400", "R-SPO-5696397", "R-RNO-5358606", "R-RNO-5358565", "R-RNO-6782135", "R-SPO-69183", "R-MMU-5656169", "R-BTA-69091", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-174411", "R-HSA-5651801", "R-HSA-69166", "R-CEL-5696397", "R-RNO-69091", "R-RNO-5685942", "R-SPO-5696400", "R-BTA-5358565", "R-SPO-6782210", "R-MMU-69166", "R-HSA-69183", "R-BTA-5685942", "R-RNO-5696400", "R-RNO-174417", "R-HSA-5696400", "R-HSA-5358565", "R-HSA-69091", "R-BTA-174414", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-MMU-69091", "R-DME-69166"], 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"R-HSA-5632684", "R-HSA-8939902", "R-CEL-2672351", "R-HSA-9692916", "R-MMU-983168", "R-CEL-9013420", "R-HSA-9013406", "R-HSA-2173788", "R-HSA-8939236", "R-DME-9013420", "R-MMU-1253288"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-4641257:r:Degradation of AXIN", "R-DME-8948747:r:Regulation of PTEN localization", "R-SCE-9013420:r:RHOU GTPase cycle", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DRE-201451:r:Signaling by BMP", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8948747:r:Regulation of PTEN localization", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-201451:r:Signaling by BMP", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DRE-4641257:r:Degradation of AXIN", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-9013406:r:RHOQ GTPase cycle", "R-MMU-201451:r:Signaling by BMP", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-9013420:r:RHOU GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-8948747:r:Regulation of PTEN localization", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-9013420:r:RHOU GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-1253288:r:Downregulation of ERBB4 signaling"], "type": "Family"}, "IPR024930": {"description": "Skp domain superfamily", "go_ids": [], "go_terms": [], "name": "Skp_dom_sf", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Homologous_superfamily"}, "IPR024931": {"description": "Importin subunit alpha", "go_ids": ["GO:0005737", "GO:0006606", "GO:0061608"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0006606:protein import into nucleus:P", "GO:0061608:nuclear import signal receptor activity:F"], "name": "Importin_alpha", "pathway_ids": ["R-HSA-140342", "R-HSA-180910", "R-HSA-9636249", "R-SPO-68616", "R-HSA-442729", "R-HSA-9705671", "R-HSA-168276", "R-BTA-68616", "R-BTA-140342", "R-MMU-5693548", "R-HSA-168271", "R-HSA-9918432", "R-DDI-909733", "R-HSA-1169408", "R-RNO-140342", "R-HSA-68616", "R-MMU-140342", "R-HSA-162592", "R-RNO-68616", "R-HSA-909733", "R-BTA-909733", "R-RNO-909733", "R-HSA-9692916", "R-MMU-68616", "R-HSA-111932", "R-DME-5693548", "R-HSA-5693548", "R-MMU-909733", "R-HSA-9018519"], "pathways": ["R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-162592:r:Integration of provirus", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Family"}, "IPR024932": {"description": "Flavin transferase ApbE", "go_ids": ["GO:0017013"], "go_terms": ["GO:0017013:protein flavinylation:P"], "name": "ApbE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024933": {"description": "Septin and tuftelin interacting protein", "go_ids": [], "go_terms": [], "name": "TFP11", "pathway_ids": ["R-SSC-72163", "R-HSA-72163", "R-RNO-72163", "R-MMU-72163"], "pathways": ["R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR024935": {"description": "Rubredoxin domain", "go_ids": ["GO:0005506"], "go_terms": ["GO:0005506:iron ion binding:F"], "name": "Rubredoxin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024936": {"description": "Cyclophilin-type peptidyl-prolyl cis-trans isomerase", "go_ids": ["GO:0003755"], "go_terms": ["GO:0003755:peptidyl-prolyl cis-trans isomerase activity:F"], "name": "Cyclophilin-type_PPIase", "pathway_ids": ["R-DDI-6782135", "R-HSA-6798695", "R-SPO-6798695", "R-MMU-210991", "R-CEL-6798695", "R-SCE-6798695", "R-BTA-6798695", "R-RNO-72163", "R-DDI-6782210", "R-DDI-72163", "R-HSA-164525", "R-HSA-2025928", "R-HSA-114608", "R-HSA-162592", "R-GGA-72163", "R-HSA-175474", "R-CEL-72163", "R-HSA-9918481", "R-HSA-210991", "R-HSA-173107", "R-BTA-72163", "R-DDI-6798695", "R-RNO-210991", "R-MMU-72163", "R-HSA-164516", "R-DDI-6781823", "R-HSA-8950505", "R-CEL-6782210", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-162594", "R-CEL-6781823", "R-HSA-72163", "R-CEL-6782135", "R-HSA-9692916", "R-MMU-6798695", "R-SPO-72163", "R-RNO-6798695"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-210991:r:Basigin interactions", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-HSA-114608:r:Platelet degranulation", "R-HSA-162592:r:Integration of provirus", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-210991:r:Basigin interactions", "R-HSA-173107:r:Binding and entry of HIV virion", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-210991:r:Basigin interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR024937": {"description": "Domain X", "go_ids": ["GO:0006397"], "go_terms": ["GO:0006397:mRNA processing:P"], "name": "Domain_X", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024940": {"description": "Transcription factor TCF/LEF", "go_ids": ["GO:0016055"], "go_terms": ["GO:0016055:Wnt signaling pathway:P"], "name": "TCF/LEF", "pathway_ids": ["R-HSA-8853884", "R-DME-9825892", "R-RNO-4641265", "R-HSA-3769402", "R-HSA-8951430", "R-RNO-201722", "R-DRE-4641265", "R-DRE-201722", "R-MMU-4086398", "R-MMU-201722", 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genes", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-8951430:r:RUNX3 regulates WNT signaling", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-4641265:r:Repression of WNT target genes", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9824272:r:Somitogenesis", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5339700:r:Signaling by TCF7L2 mutants", "R-RNO-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9823730:r:Formation of definitive endoderm", "R-CEL-4086398:r:Ca2+ pathway", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9834899:r:Specification of the neural plate border", "R-DME-4086398:r:Ca2+ pathway", "R-XTR-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DRE-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-8951430:r:RUNX3 regulates WNT signaling", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-XTR-4641265:r:Repression of WNT target genes", "R-HSA-4641265:r:Repression of WNT target genes", "R-XTR-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-4641265:r:Repression of WNT target genes", "R-DME-209441:r:WG ligand not bound to FZ receptors", "R-CEL-4641265:r:Repression of WNT target genes", "R-DME-4641265:r:Repression of WNT target genes", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-XTR-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-4086398:r:Ca2+ pathway", "R-HSA-9733709:r:Cardiogenesis", "R-RNO-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-CEL-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-8951430:r:RUNX3 regulates WNT signaling", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DME-209421:r:Transcription activation by ARM", "R-DME-8853884:r:Transcriptional Regulation by VENTX"], "type": "Family"}, "IPR024942": {"description": "Maturase MatK, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Maturase_MatK_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024943": {"description": "Enhancer of polycomb protein", "go_ids": ["GO:0035267", "GO:0006357"], "go_terms": ["GO:0035267:NuA4 histone acetyltransferase complex:C", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "Enhancer_polycomb", "pathway_ids": ["R-HSA-8953750", "R-MMU-8953750", "R-HSA-3214847"], "pathways": ["R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR024945": {"description": "Spt5 C-terminal domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Spt5_C_dom", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-GGA-112382", "R-HSA-167238", "R-MMU-113418", "R-MMU-9770562", "R-DME-4085377", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-DRE-6807505", "R-HSA-167287", "R-DRE-75955", "R-HSA-167246", "R-DRE-6796648", "R-DME-72086", "R-DRE-113418", "R-DME-4615885", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-GGA-6796648", "R-SPO-113418", "R-DME-3371453", "R-DME-674695", "R-MMU-72163", "R-DME-159227", "R-HSA-167242", "R-CEL-113418", "R-MMU-674695", "R-MMU-6807505", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-HSA-167200", "R-CEL-112382", "R-HSA-167160", "R-SCE-674695", "R-MMU-72086", "R-CEL-6796648", "R-GGA-75955", "R-GGA-674695", "R-DME-159236", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DME-159231", "R-DME-77075", "R-DRE-77075", "R-HSA-167152", "R-HSA-113418", "R-HSA-9918481", "R-DME-3108214", "R-SCE-6796648", "R-DME-113418", "R-SPO-77075", "R-CEL-75955", "R-MMU-6796648", "R-GGA-6807505", "R-HSA-9770562", "R-HSA-167243", "R-SCE-113418", "R-SCE-72086", "R-DME-4551638", "R-DRE-72086", "R-CEL-77075", "R-DME-159230", "R-DME-3301854", "R-HSA-167290", "R-DRE-674695", "R-MMU-77075", "R-HSA-75955", "R-SCE-77075", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-MMU-9770562:r:mRNA Polyadenylation", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-72086:r:mRNA Capping", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-GGA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-72086:r:mRNA Capping", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-75955:r:RNA Polymerase II Transcription Elongation", "R-GGA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-72086:r:mRNA Capping", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR024951": {"description": "Sulphate adenylyltransferase catalytic domain", "go_ids": ["GO:0004781"], "go_terms": ["GO:0004781:sulfate adenylyltransferase (ATP) activity:F"], "name": "Sulfurylase_cat_dom", "pathway_ids": ["PWY-6683", "PWY-5278", "PWY-6932", "PWY-5340", "R-MMU-174362", "R-HSA-174362", "R-HSA-2408550", "R-CEL-174362", "R-HSA-6802952", "R-HSA-3560796"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III", "PWY-5278:t:sulfite oxidation III", "PWY-6932:t:selenate reduction", "PWY-5340:t:sulfate activation for sulfonation", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-3560796:r:Defective PAPSS2 causes SEMD-PA"], "type": "Domain"}, "IPR024952": {"description": "Lipoprotein LPP20-like domain", "go_ids": [], "go_terms": [], "name": "LPP20-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024953": {"description": "Polyphosphate kinase middle domain", "go_ids": [], "go_terms": [], "name": "PP_kinase_middle", "pathway_ids": ["PWY-8138"], "pathways": ["PWY-8138:t:polyphosphate metabolism"], "type": "Domain"}, "IPR024954": {"description": "SSRP1, dimerization domain", "go_ids": [], "go_terms": [], "name": "SSRP1_DD", "pathway_ids": ["R-SPO-674695", "R-RNO-674695", "R-HSA-167238", "R-MMU-6804756", "R-DME-6796648", "R-SCE-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-DDI-674695", "R-HSA-167152", "R-DDI-6796648", "R-DDI-6804756", "R-CEL-6804756", "R-RNO-6804756", "R-SPO-6796648", "R-SCE-6796648", "R-CEL-75955", "R-MMU-6796648", "R-DME-674695", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-HSA-6804756", "R-HSA-167290", "R-RNO-112382", "R-CEL-112382", "R-HSA-75955", "R-SCE-674695", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR024956": {"description": "tRNAHis guanylyltransferase catalytic domain", "go_ids": ["GO:0006400", "GO:0008193", "GO:0000287"], "go_terms": ["GO:0006400:tRNA modification:P", "GO:0008193:tRNA guanylyltransferase activity:F", "GO:0000287:magnesium ion binding:F"], "name": "tRNAHis_GuaTrfase_cat", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR024957": {"description": "Cep57 centrosome microtubule-binding domain", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "Cep57_MT-bd_dom", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-HSA-380284", "R-MMU-380270", "R-DDI-937072", "R-HSA-380270", "R-RNO-5620912", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-RNO-380259", "R-DDI-937042", "R-HSA-2565942", "R-DDI-9020702", "R-HSA-380320", "R-DDI-450302", "R-RNO-2565942", "R-DDI-975163", "R-RNO-380270", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-DDI-5689880", "R-DDI-450321"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-9020702:r:Interleukin-1 signaling", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "type": "Domain"}, "IPR024958": {"description": "GRASP-type PDZ domain", "go_ids": [], "go_terms": [], "name": "GRASP_PDZ", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-RNO-162658", "R-RNO-6807878", "R-MMU-162658", "R-SPO-162658", "R-HSA-6807878", "R-SCE-162658", "R-MMU-6807878", "R-RNO-204005", "R-HSA-162658"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-SPO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SCE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization"], "type": "Domain"}, "IPR024960": {"description": "Phosphatidyl-N-methylethanolamine/Phosphatidylethanolamine N-methyltransferase", "go_ids": ["GO:0008757", "GO:0006656"], "go_terms": ["GO:0008757:S-adenosylmethionine-dependent methyltransferase activity:F", "GO:0006656:phosphatidylcholine biosynthetic process:P"], "name": "PEMT/MFAP", "pathway_ids": ["PWY-6825", "R-HSA-1483191", "R-SCE-1483191", "R-BTA-1483191", "R-RNO-1483191", "R-DDI-1483191", "R-SPO-1483191", "R-MMU-1483191"], "pathways": ["PWY-6825:t:phosphatidylcholine biosynthesis V", "R-HSA-1483191:r:Synthesis of PC", "R-SCE-1483191:r:Synthesis of PC", "R-BTA-1483191:r:Synthesis of PC", "R-RNO-1483191:r:Synthesis of PC", "R-DDI-1483191:r:Synthesis of PC", "R-SPO-1483191:r:Synthesis of PC", "R-MMU-1483191:r:Synthesis of PC"], "type": "Family"}, "IPR024961": {"description": "Type II secretion system protein GspC, N-terminal", "go_ids": [], "go_terms": [], "name": "T2SS_GspC_N", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR024962": {"description": "YukD-like", "go_ids": [], "go_terms": [], "name": "YukD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024964": {"description": "CTLH/CRA C-terminal to LisH motif domain", "go_ids": [], "go_terms": [], "name": "CTLH/CRA", "pathway_ids": ["R-DRE-9861718", "R-DDI-9861718", "R-MMU-9861718", "R-BTA-9861718", "R-DRE-5673001", "R-DME-9861718", "R-HSA-373760", "R-HSA-9861718", "R-GGA-9861718", "R-HSA-5673001", "R-MMU-8851805", "R-DME-373760", "R-HSA-8851805", "R-MMU-5673001", "R-RNO-9861718", "R-MMU-373760", "R-DRE-8851805"], "pathways": ["R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-GGA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-MMU-8851805:r:MET activates RAS signaling", "R-DME-373760:r:L1CAM interactions", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-MMU-373760:r:L1CAM interactions", "R-DRE-8851805:r:MET activates RAS signaling"], "type": "Domain"}, "IPR024965": {"description": "Putative integrase", "go_ids": [], "go_terms": [], "name": "Putative_integrase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024966": {"description": "Primase helical domain", "go_ids": [], "go_terms": [], "name": "Primase_helical_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024967": {"description": "DNA-binding domain, IS481-type", "go_ids": [], "go_terms": [], "name": "DNA-bd_IS481-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024968": {"description": "S-layer protein, C-terminal domain, lactobacillus", "go_ids": [], "go_terms": [], "name": "SlpA_C_lactobacillus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024969": {"description": "EIF3F/CSN6-like, C-terminal", "go_ids": [], "go_terms": [], "name": "EIF3F/CSN6-like_C", "pathway_ids": ["R-HSA-174178", "R-HSA-9604323", "R-BTA-5689880", "R-HSA-8951664", "R-BTA-9755511", "R-HSA-9010553", "R-HSA-75815", "R-MMU-8948751", "R-DME-8948751", "R-DME-5696394", "R-HSA-72695", "R-SPO-5689880", "R-MMU-5689880", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-DME-5676590", "R-MMU-5696394", "R-HSA-450408", "R-CEL-5696394", "R-SCE-5689880", "R-HSA-211733", "R-DDI-6798695", "R-DME-4641257", "R-DME-432524", "R-HSA-5607761", "R-DDI-174084", "R-MMU-9932298", "R-HSA-72706", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-DDI-5696394", "R-BTA-69017", "R-HSA-180534", "R-BTA-4641257", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-DDI-187577", "R-DDI-72689", "R-DDI-382556", "R-DME-202424", "R-DME-187577", "R-MMU-187577", "R-BTA-1236978", "R-DME-72649", "R-HSA-156827", "R-HSA-9824272", "R-MMU-174178", "R-BTA-4608870", "R-BTA-5676590", "R-MMU-349425", "R-DME-350562", "R-HSA-9907900", "R-DME-174084", "R-BTA-2871837", "R-BTA-174154", "R-DDI-69601", "R-DME-9929491", "R-HSA-9762114", "R-DDI-5689880", "R-HSA-195253", "R-SSC-6781823", "R-BTA-187577", "R-DME-6798695", "R-DME-8939236", "R-DME-174184", "R-BTA-9929356", "R-MMU-5676590", "R-MMU-174184", "R-HSA-8856825", "R-DME-9932298", "R-BTA-9954709", "R-DME-9020702", "R-DDI-156827", "R-DME-5689880", "R-SPO-350562", "R-HSA-5358346", "R-CEL-8951664", "R-HSA-6798695", "R-MMU-5632684", "R-SPO-9907900", "R-BTA-5610785", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-BTA-6798695", "R-DDI-1236978", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-72706", "R-MMU-8951664", "R-DME-8939902", "R-MMU-9929356", "R-DME-4608870", "R-SCE-5668541", "R-DME-9762114", "R-HSA-69481", "R-BTA-174084", "R-SPO-72706", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DDI-6781823", "R-HSA-4641258", "R-SPO-5689603", "R-DME-1236978", "R-CEL-6781823", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-DME-8941858", "R-SPO-72702", "R-SPO-6798695", "R-MMU-5610780", "R-DME-9954709", "R-BTA-382556", "R-CEL-72702", "R-MMU-9755511", "R-CEL-72695", "R-MMU-9954709", "R-DDI-75815", "R-MMU-72649", "R-HSA-2871837", "R-DME-5689603", "R-HSA-5362768", "R-DDI-9954709", "R-DME-216167", "R-SSC-8856825", "R-MMU-5658442", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-BTA-8948751", "R-DME-72695", "R-MMU-72702", "R-HSA-1236978", "R-HSA-69601", "R-HSA-72689", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-HSA-69017", "R-BTA-9020702", "R-BTA-5607764", "R-DDI-450408", "R-MMU-1236978", "R-HSA-202424", "R-DDI-174154", "R-MMU-450408", "R-HSA-9020702", "R-MMU-8941858", "R-HSA-5689880", "R-MMU-174154", "R-BTA-1234176", "R-MMU-69017", "R-DME-5658442", "R-MMU-9020702", "R-MMU-69481", "R-BTA-350562", "R-DDI-8856825", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-BTA-68867", "R-HSA-1234176", "R-MMU-68867", "R-HSA-9931269", "R-HSA-9929491", "R-DME-209461", "R-HSA-72702", "R-DME-75815", "R-HSA-5696394", "R-DME-69601", "R-CEL-72649", "R-DME-1234176", "R-HSA-1236974", "R-MMU-5687128", "R-DME-72702", "R-CEL-8856825", "R-DME-5358346", "R-SPO-72689", "R-CEL-72689", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-HSA-2467813", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-MMU-72689", "R-SCE-6798695", "R-MMU-68949", "R-MMU-8939236", "R-MMU-6781823", "R-DME-9907900", "R-DDI-5689603", "R-DDI-2467813", "R-BTA-174184", "R-MMU-9762114", "R-MMU-195253", "R-MMU-202424", "R-MMU-72695", "R-MMU-382556", "R-HSA-5610780", "R-BTA-8939236", "R-DME-209360", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-DME-72689", "R-MMU-1169091", "R-DME-432626", "R-HSA-72649", "R-MMU-5607761", "R-MMU-156827", "R-DME-8854050", "R-HSA-8939902", "R-MMU-8939902", "R-DME-174178", "R-HSA-8939236", "R-BTA-983168", "R-DDI-8854050", "R-MMU-5607764", "R-DME-6781823", "R-DME-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-HSA-5676590", "R-DDI-5632684", "R-BTA-9929491", "R-HSA-4641257", "R-MMU-9929491", "R-HSA-174113", "R-BTA-9932298", "R-BTA-9762114", "R-HSA-68867", "R-DME-174154", "R-MMU-9907900", "R-BTA-450408", "R-DDI-5658442", "R-DDI-72695", "R-HSA-8941858", "R-HSA-9755511", "R-DME-9755511", "R-CEL-156827", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-SPO-156827", "R-HSA-5689603", "R-DME-450408", "R-DDI-72702", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-DME-1169091", "R-HSA-187577", "R-DME-156827", "R-DDI-9755511", "R-MMU-8856825", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-BTA-8941858", "R-DME-4641258", "R-SSC-8951664", "R-HSA-174184", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-DME-68949", "R-DME-8856825", "R-SPO-72649", "R-SPO-72695", "R-HSA-382556", "R-HSA-8852276", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-DME-5632684", "R-HSA-5687128", "R-DME-432395", "R-MMU-983168", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9907900:r:Proteasome assembly", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-4641258:r:Degradation of DVL", "R-SPO-5689603:r:UCH proteinases", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-DME-5689603:r:UCH proteinases", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-216167:r:Nuclear CI is degraded", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5689603:r:UCH proteinases", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-68867:r:Assembly of the 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"R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-9907900:r:Proteasome assembly", "R-DDI-5689603:r:UCH proteinases", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-432626:r:Circadian Clock pathway", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-5632684:r:Hedgehog 'on' state", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4641257:r:Degradation of AXIN", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9907900:r:Proteasome assembly", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-5689603:r:UCH proteinases", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-SSC-8951664:r:Neddylation", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-432395:r:Degradation of TIM", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR024970": {"description": "Maelstrom domain", "go_ids": ["GO:0060964"], "go_terms": ["GO:0060964:regulation of miRNA-mediated gene silencing:P"], "name": "Maelstrom", "pathway_ids": ["R-HSA-5601884"], "pathways": ["R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis"], "type": "Domain"}, "IPR024972": {"description": "HNS-dependent expression A", "go_ids": ["GO:0071468", "GO:0030288"], "go_terms": ["GO:0071468:cellular response to acidic pH:P", "GO:0030288:outer membrane-bounded periplasmic space:C"], "name": "HdeA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024973": {"description": "ESPR domain", "go_ids": [], "go_terms": [], "name": "ESPR", "pathway_ids": ["R-HSA-9927020"], "pathways": ["R-HSA-9927020:r:Heme assimilation"], "type": "Domain"}, "IPR024974": {"description": "Sde2, ubiquitin domain", "go_ids": [], "go_terms": [], "name": "Sde2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024975": {"description": "Protein NO VEIN, C-terminal", "go_ids": [], "go_terms": [], "name": "NOV_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024976": {"description": "Domain of unknown function DUF3885", "go_ids": [], "go_terms": [], "name": "DUF3885", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024977": {"description": "Anaphase-promoting complex subunit 4-like, WD40 domain", "go_ids": [], "go_terms": [], "name": 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early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin 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mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Domain"}, "IPR024978": {"description": "Homeodomain, phBC6A51-type", "go_ids": [], "go_terms": [], "name": "Homeodomain_phBC6A51-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024979": {"description": "Protein of unknown function DUF3884", "go_ids": [], "go_terms": [], "name": "DUF3884", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024980": {"description": "Protein of unknown function DUF3886", "go_ids": [], "go_terms": [], "name": "DUF3886", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR024981": {"description": "Domain of unknown function DUF3887", "go_ids": [], "go_terms": [], "name": "DUF3887", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR024982": {"description": "Rax2-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Rax2-like_C", 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"DUF3910", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025022": {"description": "Protein of unknown function DUF3911", "go_ids": [], "go_terms": [], "name": "DUF3911", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025023": {"description": "Protein of unknown function DUF3912", "go_ids": [], "go_terms": [], "name": "DUF3912", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025024": {"description": "Protein of unknown function DUF3913", "go_ids": [], "go_terms": [], "name": "DUF3913", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025025": {"description": "Protein of unknown function DUF3914", "go_ids": [], "go_terms": [], "name": "DUF3914", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025026": {"description": "Protein of unknown function DUF3915", "go_ids": [], "go_terms": [], "name": "DUF3915", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025027": {"description": "Protein of unknown function DUF3917", "go_ids": [], "go_terms": [], "name": "DUF3917", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025028": {"description": "Protein of unknown function DUF3951", "go_ids": [], "go_terms": [], "name": "DUF3951", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025029": {"description": "Protein of unknown function DUF3918", "go_ids": [], "go_terms": [], "name": "DUF3918", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025030": {"description": "Domain of unknown function DUF3950", "go_ids": [], "go_terms": [], "name": "DUF3950", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025031": {"description": "Protein of unknown function DUF3919", "go_ids": [], "go_terms": [], "name": "DUF3919", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025032": {"description": "Protein of unknown function DUF3949", "go_ids": [], "go_terms": [], "name": "DUF3949", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025033": {"description": "Protein of unknown function DUF3920", "go_ids": [], "go_terms": [], "name": "DUF3920", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025034": {"description": "Protein of unknown function DUF3948", "go_ids": [], "go_terms": [], "name": "DUF3948", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025035": {"description": "Protein of unknown function DUF3922", "go_ids": [], "go_terms": [], "name": "DUF3922", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025036": {"description": "Protein of unknown function DUF3921", "go_ids": [], "go_terms": [], "name": "DUF3921", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025037": {"description": "Protein of unknown function DUF3923", "go_ids": [], "go_terms": [], "name": "DUF3923", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025038": {"description": "Protein of unknown function DUF3924", "go_ids": [], "go_terms": [], "name": "DUF3924", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025039": {"description": "Protein of unknown function DUF3947", "go_ids": [], "go_terms": [], "name": "DUF3947", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025040": {"description": "Protein of unknown function DUF3984", "go_ids": [], "go_terms": [], "name": "DUF3984", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025041": {"description": "Protein of unknown function DUF3983", "go_ids": [], "go_terms": [], "name": "DUF3983", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025043": {"description": "Domain of unknown function DUF3981", "go_ids": [], "go_terms": [], "name": "DUF3981", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025044": {"description": "Domain of unknown function DUF3980", "go_ids": [], "go_terms": [], "name": "DUF3980", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025045": {"description": "Protein of unknown function DUF3979", "go_ids": [], "go_terms": [], "name": "DUF3979", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025046": {"description": "Domain of unknown function DUF3960", "go_ids": [], "go_terms": [], "name": "DUF3960", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025047": {"description": "Protein of unknown function DUF3986", "go_ids": [], "go_terms": [], "name": "DUF3986", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025048": {"description": "Domain of unknown function DUF3987)", "go_ids": [], "go_terms": [], "name": "DUF3987", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025049": {"description": "Fimbrillin-like 1", "go_ids": [], "go_terms": [], "name": "Mfa-like_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025050": {"description": "Conjugative transposon protein TraL", "go_ids": [], "go_terms": [], "name": "TraL_transposon", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025051": {"description": "Protein of unknown function DUF3990", "go_ids": [], "go_terms": [], "name": "DUF3990", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025052": {"description": "Domain of unknown function DUF3967", "go_ids": [], "go_terms": [], "name": "DUF3967", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025053": {"description": "Protein of unknown function DUF3985", "go_ids": [], "go_terms": [], "name": "DUF3985", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025054": {"description": "Domain of unknown function DUF3991", "go_ids": [], "go_terms": [], "name": "DUF3991", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025055": {"description": "Endospore appendages core", "go_ids": [], "go_terms": [], "name": "Ena_core", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025056": {"description": "Protein of unknown function DUF3993", "go_ids": [], "go_terms": [], "name": "DUF3993", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025057": {"description": "Domain of unknown function DUF3994", "go_ids": [], "go_terms": [], "name": "DUF3994", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025058": {"description": "Protein of unknown function DUF3995", "go_ids": [], "go_terms": [], "name": "DUF3995", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025059": {"description": "Protein of unknown function DUF3997", "go_ids": [], "go_terms": [], "name": "DUF3997", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025060": {"description": "Protein of unknown function DUF3999", "go_ids": [], "go_terms": [], "name": "DUF3999", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025061": {"description": "Diedel", "go_ids": [], "go_terms": [], "name": "Diedel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025062": {"description": "Protein of unknown function DUF4003", "go_ids": [], "go_terms": [], "name": "DUF4003", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025063": {"description": "Protein of unknown function DUF4004", "go_ids": [], "go_terms": [], "name": "DUF4004", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025064": {"description": "Domain of unknown function DUF4005", "go_ids": [], "go_terms": [], "name": "DUF4005", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025065": {"description": "Protein of unknown function DUF4006", "go_ids": [], "go_terms": [], "name": "DUF4006", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025066": {"description": "Coiled-coil domain-containing protein 174-like", "go_ids": [], "go_terms": [], "name": "CCDC174-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025067": {"description": "Protein of unknown function DUF4079", "go_ids": [], "go_terms": [], "name": "DUF4079", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025068": {"description": "Protein of unknown function DUF3937", "go_ids": [], "go_terms": [], "name": "DUF3937", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025069": {"description": "Cleavage and polyadenylation specificity factor 2, C-terminal", "go_ids": [], "go_terms": [], "name": "Cpsf2_C", "pathway_ids": ["R-CEL-159231", "R-HSA-9770562", "R-DME-77595", "R-MMU-9770562", "R-SPO-159231", "R-SCE-77595", "R-MMU-77595", "R-MMU-73856", "R-BTA-73856", "R-HSA-73856", "R-DDI-9770562", "R-CEL-73856", "R-HSA-72187", "R-DME-159231", "R-SPO-77595", "R-CEL-77595", "R-HSA-159231", "R-HSA-77595", "R-SPO-9770562", "R-DME-9770562", "R-MMU-72187", "R-DDI-77595", "R-CEL-9770562", "R-BTA-9770562", "R-BTA-159231", "R-DME-73856", "R-HSA-9918481", "R-MMU-159231", "R-BTA-77595"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR025070": {"description": "Protein of unknown function DUF3938", "go_ids": [], "go_terms": [], "name": "DUF3938", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025071": {"description": "Protein of unknown function DUF3939", "go_ids": [], "go_terms": [], "name": "DUF3939", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025072": {"description": "Fur-regulated basic protein A", "go_ids": [], "go_terms": [], "name": "Fur_reg_FbpA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025073": {"description": "Protein of unknown function DUF3909", "go_ids": [], "go_terms": [], "name": "DUF3909", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025074": {"description": "Protein of unknown function DUF3942", "go_ids": [], "go_terms": [], "name": "DUF3942", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025075": {"description": "Protein of unknown function DUF3916", "go_ids": [], "go_terms": [], "name": "DUF3916", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025076": {"description": "Protein of unknown function DUF3926", "go_ids": [], "go_terms": [], "name": "DUF3926", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025077": {"description": "Protein of unknown function DUF3941", "go_ids": [], "go_terms": [], "name": "DUF3941", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025078": {"description": "Protein of unknown function DUF3931", "go_ids": [], "go_terms": [], "name": "DUF3931", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025079": {"description": "Domain of unknown function DUF3943", "go_ids": [], "go_terms": [], "name": "DUF3943", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025080": {"description": "Protein of unknown function DUF3959", "go_ids": [], "go_terms": [], "name": "DUF3959", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025081": {"description": "Domain of unknown function DUF3961", "go_ids": [], "go_terms": [], "name": "DUF3961", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025082": {"description": "Protein of unknown function DUF3964", "go_ids": [], "go_terms": [], "name": "DUF3964", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025083": {"description": "Protein of unknown function DUF3969", "go_ids": [], "go_terms": [], "name": "DUF3969", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025084": {"description": "Protein of unknown function DUF3966", "go_ids": [], "go_terms": [], "name": "DUF3966", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025085": {"description": "pPIWI_RE module, N-terminal domain", "go_ids": [], "go_terms": [], "name": "pPIWI_RE_X", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025086": {"description": "SDE2/SF3A3, SAP domain", "go_ids": [], "go_terms": [], "name": "SDE2/SF3A3_SAP", "pathway_ids": ["R-DME-9770562", "R-HSA-72163", "R-DRE-72163", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-DME-72163", "R-RNO-72163", "R-HSA-9918481"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR025087": {"description": "Domain of unknown function DUF3965", "go_ids": [], "go_terms": [], "name": "DUF3965", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025088": {"description": "Protein of unknown function DUF3970", "go_ids": [], "go_terms": [], "name": "DUF3970", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025089": {"description": "Protein of unknown function DUF4018", "go_ids": [], "go_terms": [], "name": "DUF4018", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025090": {"description": "Protein of unknown function DUF4017", "go_ids": [], "go_terms": [], "name": "DUF4017", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025091": {"description": "Protein of unknown function DUF4019", "go_ids": [], "go_terms": [], "name": "DUF4019", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025092": {"description": "Glycosyl hydrolase family 66", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_66", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025093": {"description": "Domain of unknown function DUF4020", "go_ids": [], "go_terms": [], "name": "DUF4020", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025094": {"description": "Protein of unknown function DUF4021", "go_ids": [], "go_terms": [], "name": "DUF4021", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025095": {"description": "Protein of unknown function DUF4022", "go_ids": [], "go_terms": [], "name": "DUF4022", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025096": {"description": "Protein of unknown function DUF4014", "go_ids": [], "go_terms": [], "name": "DUF4014", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025097": {"description": "Protein of unknown function DUF4023", "go_ids": [], "go_terms": [], "name": "DUF4023", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025098": {"description": "Protein of unknown function DUF4013", "go_ids": [], "go_terms": [], "name": "DUF4013", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025099": {"description": "Protein of unknown function DUF4024", "go_ids": [], "go_terms": [], "name": "DUF4024", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025100": {"description": "Protein of unknown function DUF4025", "go_ids": [], "go_terms": [], "name": "DUF4025", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025101": {"description": "Protein of unknown function DUF4012", "go_ids": [], "go_terms": [], "name": "DUF4012", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025102": {"description": "DUF4026, N-terminal", "go_ids": [], "go_terms": [], "name": "DUF4026_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025103": {"description": "Uncharacterized ATP-dependent helicase MG140, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF4011", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025104": {"description": "Protein of unknown function DUF4027", "go_ids": [], "go_terms": [], "name": "DUF4027", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025105": {"description": "Domain of unknown function DUF4010", "go_ids": [], "go_terms": [], "name": "DUF4010", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025106": {"description": "Protein of unknown function DUF4028", "go_ids": [], "go_terms": [], "name": "DUF4028", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025107": {"description": "Protein of unknown function DUF4029", "go_ids": [], "go_terms": [], "name": "DUF4029", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025108": {"description": "Protein of unknown function DUF4030", "go_ids": [], "go_terms": [], "name": "DUF4030", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025109": {"description": "Domain of unknown function DUF4031", "go_ids": [], "go_terms": [], "name": "DUF4031", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025110": {"description": "AMP-binding enzyme, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AMP-bd_C", "pathway_ids": ["R-HSA-6798695", "R-DDI-71384", "R-HSA-804914", "R-HSA-1989781", "R-MMU-177135", "R-HSA-2151201", "R-HSA-389599", "R-HSA-177128", "R-MMU-193775", "R-BTA-77111", "R-HSA-193368", "R-MTU-9635470", "R-RNO-75105", "R-HSA-177135", "R-MMU-77111", "R-MMU-75876", "R-DDI-77111", "R-SCE-71384", "R-MMU-389599", "R-HSA-9841922", "R-HSA-77111", "R-RNO-9033241", "R-DRE-77289", "R-MMU-159418", "R-DME-71384", "R-RNO-159418", "R-RNO-77289", "R-MMU-9749641", "R-HSA-5619108", "R-HSA-77352", "R-CEL-77111", "R-HSA-77289", "R-RNO-804914", "R-HSA-193775", "R-HSA-177162", "R-MMU-193368", "R-RNO-77111", "R-BTA-77289", "R-HSA-2142753", "R-RNO-177162", "R-MMU-9033241", "R-MMU-177162", "R-MMU-75105", "R-HSA-71384", "R-MMU-2151201", "R-SPO-71384", "R-MMU-804914", "R-RNO-193775", "R-RNO-389599", "R-RNO-177135", "R-HSA-75105", "R-HSA-390247", "R-MMU-390247", "R-RNO-9749641", "R-MMU-6798695", "R-HSA-9749641", "R-RNO-193368", "R-BTA-75876", "R-MMU-177128", "R-RNO-177128", "R-MMU-77289", "R-HSA-159418", "R-HSA-75876", "R-HSA-9033241", "R-RNO-6798695", "R-RNO-390247", "R-MMU-71384"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-71384:r:Ethanol oxidation", "R-HSA-804914:r:Transport of fatty acids", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-177135:r:Conjugation of benzoate with glycine", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-HSA-177128:r:Conjugation of salicylate with glycine", "R-MMU-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-BTA-77111:r:Synthesis of Ketone Bodies", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-177135:r:Conjugation of benzoate with glycine", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-DDI-77111:r:Synthesis of Ketone Bodies", "R-SCE-71384:r:Ethanol oxidation", "R-MMU-389599:r:Alpha-oxidation of phytanate", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-RNO-9033241:r:Peroxisomal protein import", "R-DRE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-159418:r:Recycling of bile acids and salts", "R-DME-71384:r:Ethanol oxidation", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-5619108:r:Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-CEL-77111:r:Synthesis of Ketone Bodies", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-804914:r:Transport of fatty acids", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-HSA-177162:r:Conjugation of phenylacetate with glutamine", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-2142753:r:Arachidonate 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"pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025194": {"description": "Cytoskeleton protein RodZ-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RodZ-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025195": {"description": "GTA, TIM-barrel-like domain", "go_ids": [], "go_terms": [], "name": "GTA_TIM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025196": {"description": "Domain of unknown function DUF4126", "go_ids": [], "go_terms": [], "name": "DUF4126", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025197": {"description": "Domain of unknown function DUF4116", "go_ids": [], "go_terms": [], "name": "DUF4116", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025198": {"description": "Polyphosphate kinase N-terminal domain", "go_ids": [], "go_terms": [], "name": "PPK_N_dom", "pathway_ids": ["PWY-8138"], "pathways": ["PWY-8138:t:polyphosphate metabolism"], "type": "Domain"}, "IPR025199": {"description": "DNA translocase FtsK, 4TM region", "go_ids": [], "go_terms": [], "name": "FtsK_4TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025200": {"description": "Polyphosphate kinase C-terminal domain 2", "go_ids": [], "go_terms": [], "name": "PPK_C_dom2", "pathway_ids": ["PWY-8138"], "pathways": ["PWY-8138:t:polyphosphate metabolism"], "type": "Domain"}, "IPR025201": {"description": "Sensor protein KdpD, transmembrane domain", "go_ids": [], "go_terms": [], "name": "KdpD_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025202": {"description": "Cardiolipin synthase-like, phospholipase D-like domain", "go_ids": [], "go_terms": [], "name": "PLD-like_dom", "pathway_ids": ["PWY-6580", "PWY-6350", "PWY-7817", "PWY-7981", "PWY-7819", "PWY-6804", "PWY-7820", "PWY-8248", "PWY-7816", "PWY-7818", "PWY-7815", "R-BTA-1483166", "R-MMU-1483166", "R-DRE-1483166", "R-HSA-1483166", "R-XTR-1483166", "R-HSA-1483148", "R-DME-1483166", "R-HSA-5601884"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-6350:t:archaetidylinositol biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-6804:t:diacylglycerol biosynthesis (PUFA enrichment in oilseed)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "R-BTA-1483166:r:Synthesis of PA", "R-MMU-1483166:r:Synthesis of PA", "R-DRE-1483166:r:Synthesis of PA", "R-HSA-1483166:r:Synthesis of PA", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-1483148:r:Synthesis of PG", "R-DME-1483166:r:Synthesis of PA", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis"], "type": "Domain"}, "IPR025203": {"description": "Putative quorum-sensing-regulated virulence factor, QSregVF", "go_ids": [], "go_terms": [], "name": "QSregVF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025204": {"description": "Centromere subunit L", "go_ids": [], "go_terms": [], "name": "CENP-L", "pathway_ids": ["R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-RNO-606279", "R-XTR-2467813", "R-MMU-606279", "R-BTA-5663220", "R-MMU-68877", "R-DRE-2467813", "R-BTA-606279", "R-DRE-141444", "R-GGA-2500257", "R-XTR-141444", "R-XTR-606279", "R-BTA-2467813", "R-HSA-68877", "R-GGA-9648025", "R-BTA-2500257", "R-GGA-5663220", "R-DRE-5663220", "R-GGA-2467813", "R-MMU-9648025", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-HSA-606279", "R-MMU-141444", "R-HSA-2500257", "R-DRE-2500257", "R-HSA-141444", "R-XTR-5663220", "R-HSA-9648025", "R-XTR-68877", "R-RNO-5663220", "R-GGA-141444", "R-GGA-606279", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-BTA-9648025", "R-BTA-141444", "R-XTR-2500257", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory 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"R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR025213": {"description": "Kinetochore Sim4 complex subunit Fta2", "go_ids": [], "go_terms": [], "name": "Sim4_Fta2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025214": {"description": "Centromere protein U", "go_ids": [], "go_terms": [], "name": "CENP-U", "pathway_ids": ["R-HSA-606279", "R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-RNO-2500257", "R-RNO-606279", "R-MMU-2467813", "R-HSA-141444", "R-MMU-606279", "R-HSA-9648025", "R-MMU-68877", "R-RNO-5663220", "R-HSA-68877", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR025216": {"description": "Domain of unknown function DUF4427", "go_ids": [], "go_terms": [], "name": "DUF4427", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025217": {"description": "UPF0174-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "UPF0174_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025218": {"description": "Domain of unknown function DUF4426", "go_ids": [], "go_terms": [], "name": "DUF4426", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025219": {"description": "PLAT/LH2 and C2-like Ca2+-binding lipoprotein", "go_ids": [], "go_terms": [], "name": "PLCC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025220": {"description": "Nuclear factor related to kappa-B-binding protein, winged helix-like domain", "go_ids": [], "go_terms": [], "name": 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"go_ids": [], "go_terms": [], "name": "DUF4189", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025241": {"description": "Domain of unknown function DUF4190", "go_ids": [], "go_terms": [], "name": "DUF4190", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025242": {"description": "Protein of unknown function DUF4193", "go_ids": [], "go_terms": [], "name": "DUF4193", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025243": {"description": "Domain of unknown function DUF4195", "go_ids": [], "go_terms": [], "name": "DUF4195", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025244": {"description": "Coiled-coil domain-containing protein 82", "go_ids": [], "go_terms": [], "name": "CCDC82", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025245": {"description": "Protein of unknown function DUF4197", "go_ids": [], "go_terms": [], "name": "DUF4197", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025246": {"description": "Transposase IS30-like HTH domain", "go_ids": [], "go_terms": [], "name": "IS30-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025247": {"description": "Type II methyltransferase M.EcoRI-like", "go_ids": [], "go_terms": [], "name": "EcoRI-like_methylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025248": {"description": "Domain of unknown function DUF4007", "go_ids": [], "go_terms": [], "name": "DUF4007", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025249": {"description": "Transcription factor NusA, first KH domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "TF_NusA_KH_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025250": {"description": "Protein of unknown function DUF4199", "go_ids": [], "go_terms": [], "name": "DUF4199", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025251": {"description": "Domain of unknown function DUF4213", "go_ids": [], "go_terms": [], "name": "DUF4213", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025252": {"description": "Domain of unknown function DUF4200", "go_ids": [], "go_terms": [], "name": "DUF4200", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025253": {"description": "Type I toxin-antitoxin system, toxin Ldr", "go_ids": [], "go_terms": [], "name": "Toxin_Ldr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025254": {"description": "CCDC113/CCDC96, coiled-coil", "go_ids": [], "go_terms": [], "name": "CCDC113/CCDC96_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025255": {"description": "Protein of unknown function DUF4202", "go_ids": [], "go_terms": [], "name": "DUF4202", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025256": {"description": "TM7S3/TM198-like domain", "go_ids": [], "go_terms": [], "name": "TM7S3/TM198-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025257": {"description": "Deubiquitinating enzyme MINDY-3/4, conserved domain", "go_ids": [], "go_terms": [], "name": "MINDY-3/4_CD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025258": {"description": "Rubicon Homology Domain", "go_ids": [], "go_terms": [], "name": "RH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025259": {"description": "Coiled-coil domain-containing protein 34/181", "go_ids": [], "go_terms": [], "name": "CCDC34/181", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025260": {"description": "Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CHD1-like_C", "pathway_ids": ["PWY-7250", "R-HSA-9018519"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR025261": {"description": "Atos-like, conserved domain", "go_ids": [], "go_terms": [], "name": "Atos-like_cons_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025262": {"description": "Quorum-sensing regulator protein G", "go_ids": [], "go_terms": [], "name": "QseG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025263": {"description": "YhdP, central domain", "go_ids": [], "go_terms": [], "name": "YhdP_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025264": {"description": "Cag pathogenicity island protein Cag12", "go_ids": [], "go_terms": [], "name": "Cag12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025265": {"description": "WPP domain", "go_ids": [], "go_terms": [], "name": "WPP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025266": {"description": "TerB, N-terminal", "go_ids": [], "go_terms": [], "name": "TerB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025267": {"description": "Major capsid protein ORF017-like", "go_ids": [], "go_terms": [], "name": "ORF017-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025269": {"description": "Phage integrase SAM-like domain", "go_ids": [], "go_terms": [], "name": "SAM-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025270": {"description": "Protein of unknown function DUF4044", "go_ids": [], "go_terms": [], "name": "DUF4044", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025271": {"description": "Coiled-coil domain-containing protein 28", "go_ids": [], "go_terms": [], "name": "CCDC28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025272": {"description": "Antitoxin SocA-like, Panacea domain", "go_ids": [], "go_terms": [], "name": "SocA_Panacea", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025273": {"description": "Domain of unknown function DUF4064", "go_ids": [], "go_terms": [], "name": "DUF4064", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025274": {"description": "Domain of unknown function DUF4070", "go_ids": [], "go_terms": [], "name": "DUF4070", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025275": {"description": "Putative glycosyl hydrolase domain DUF4015", "go_ids": [], "go_terms": [], "name": "DUF4015", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025276": {"description": "Protein of unknown function DUF4075", "go_ids": [], "go_terms": [], "name": "DUF4075", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025277": {"description": "Apiosidase-like, catalytic domain", "go_ids": [], "go_terms": [], "name": "Apiosidase-like_cat_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025278": {"description": "Domain of unknown function DUF4077", "go_ids": [], "go_terms": [], "name": "DUF4077", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025279": {"description": "Stress response protein NST1", "go_ids": [], "go_terms": [], "name": "NST1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025280": {"description": "SNIPE middle domain", "go_ids": [], "go_terms": [], "name": "SNIPE_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025281": {"description": "Domain of unknown function DUF4074", "go_ids": [], "go_terms": [], "name": "DUF4074", "pathway_ids": ["R-HSA-5617472"], "pathways": ["R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "type": "Domain"}, "IPR025282": {"description": "Domain of unknown function DUF4214", "go_ids": [], "go_terms": [], "name": "DUF4214", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025283": {"description": "Domain of unknown function DUF4042", "go_ids": [], "go_terms": [], "name": "DUF4042", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025284": {"description": "Protein of unknown function DUF4144", "go_ids": [], "go_terms": [], "name": "DUF4144", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025285": {"description": "Domain of unknown function DUF4145", "go_ids": [], "go_terms": [], "name": "DUF4145", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025286": {"description": "MOFRL-associated domain", "go_ids": [], "go_terms": [], "name": "MOFRL_assoc_dom", "pathway_ids": ["R-HSA-70350", "R-BTA-70350", "R-RNO-70350", "R-DME-70350", "R-DRE-70350", "R-CEL-70350", "R-MMU-70350"], "pathways": ["R-HSA-70350:r:Fructose catabolism", "R-BTA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-DME-70350:r:Fructose catabolism", "R-DRE-70350:r:Fructose catabolism", "R-CEL-70350:r:Fructose catabolism", "R-MMU-70350:r:Fructose catabolism"], "type": "Domain"}, "IPR025287": {"description": "Wall-associated receptor kinase, galacturonan-binding domain", "go_ids": ["GO:0030247"], "go_terms": ["GO:0030247:polysaccharide binding:F"], "name": "WAK_GUB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025288": {"description": "Domain of unknown function DUF4080", "go_ids": [], "go_terms": [], "name": "DUF4080", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025289": {"description": "Domain of unknown function DUF4081", "go_ids": [], "go_terms": [], "name": "DUF4081", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025291": {"description": "Protein of unknown function DUF4153", "go_ids": [], "go_terms": [], "name": "DUF4153", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025292": {"description": "Type III secretion system protein", "go_ids": [], "go_terms": [], "name": "T3SS_LEE_assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025293": {"description": "YfiR/HmsC-like", "go_ids": [], "go_terms": [], "name": "YfiR/HmsC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025294": {"description": "Protein of unknown function DUF4156", "go_ids": [], "go_terms": [], "name": "DUF4156", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025295": {"description": "eCIS core domain", "go_ids": [], "go_terms": [], "name": "eCIS_core_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025296": {"description": "Domain of unknown function DUF4158", "go_ids": [], "go_terms": [], "name": "DUF4158", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025297": {"description": "Domain of unknown function DUF4159", "go_ids": [], "go_terms": [], "name": "DUF4159", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025298": {"description": "Domain of unknown function DUF4094", "go_ids": [], "go_terms": [], "name": "DUF4094", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 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"pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025306": {"description": "Probable zinc-binding domain", "go_ids": [], "go_terms": [], "name": "Zn-bnd_dom_prob", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025307": {"description": "FIIND domain", "go_ids": [], "go_terms": [], "name": "FIIND_dom", "pathway_ids": ["R-RNO-844455", "R-HSA-9627069", "R-HSA-111458", "R-HSA-844455", "R-DRE-844456", "R-MMU-844455", "R-DRE-5689901"], "pathways": ["R-RNO-844455:r:The NLRP1 inflammasome", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-844455:r:The NLRP1 inflammasome", "R-DRE-844456:r:The NLRP3 inflammasome", "R-MMU-844455:r:The NLRP1 inflammasome", "R-DRE-5689901:r:Metalloprotease DUBs"], "type": "Domain"}, "IPR025309": {"description": "KTSC domain", "go_ids": [], "go_terms": [], "name": "KTSC_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025310": {"description": "Protein of unknown function DUF4164", "go_ids": [], "go_terms": [], "name": "DUF4164", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025311": {"description": "Domain of unknown function DUF4166", "go_ids": [], "go_terms": [], "name": "DUF4166", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025312": {"description": "Domain of unknown function DUF4216", "go_ids": [], "go_terms": [], "name": "DUF4216", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025313": {"description": "ATP-dependent rRNA helicase SPB4-like, C-terminal extension", "go_ids": [], "go_terms": [], "name": "SPB4-like_CTE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025314": {"description": "Domain of unknown function DUF4219", "go_ids": [], "go_terms": [], "name": "DUF4219", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025315": {"description": "Domain of unknown function DUF4220", "go_ids": [], "go_terms": [], "name": "DUF4220", "pathway_ids": [], "pathways": [], "type": "Domain"}, 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"pathways": [], "type": "Family"}, "IPR025322": {"description": "PADRE domain", "go_ids": [], "go_terms": [], "name": "PADRE_dom", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025323": {"description": "Protein of unknown function DUF4229", "go_ids": [], "go_terms": [], "name": "DUF4229", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025324": {"description": "Protein of unknown function DUF4230", "go_ids": [], "go_terms": [], "name": "DUF4230", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025325": {"description": "Protein of unknown function DUF4231", "go_ids": [], "go_terms": [], "name": "DUF4231", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025326": {"description": "Domain of unknown function DUF4232", "go_ids": [], "go_terms": [], "name": "DUF4232", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025327": {"description": "Protein of unknown function DUF4233", "go_ids": [], "go_terms": [], "name": "DUF4233", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025328": {"description": "Domain of unknown function DUF4234", "go_ids": [], "go_terms": [], "name": "DUF4234", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025329": {"description": "Protein of unknown function DUF4235", "go_ids": [], "go_terms": [], "name": "DUF4235", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025330": {"description": "Domain of unknown function DUF4236", "go_ids": [], "go_terms": [], "name": "DUF4236", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025331": {"description": "Tuberculosis necrotizing toxin", "go_ids": ["GO:0050135"], "go_terms": ["GO:0050135:NADP+ nucleosidase activity:F"], "name": "TNT", "pathway_ids": ["R-HSA-9637698"], "pathways": ["R-HSA-9637698:r:Phagocyte cell death caused by cytosolic Mtb"], "type": "Domain"}, "IPR025332": {"description": "Protein of unknown function DUF4238", "go_ids": [], "go_terms": [], "name": "DUF4238", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025333": {"description": "Protein of unknown function DUF4239", "go_ids": [], "go_terms": [], "name": "DUF4239", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025334": {"description": "Domain of unknown function DUF4240", "go_ids": [], "go_terms": [], "name": "DUF4240", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025335": {"description": "Protein of unknown function DUF4241", "go_ids": [], "go_terms": [], "name": "DUF4241", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025336": {"description": "SCO4226-like", "go_ids": [], "go_terms": [], "name": "SCO4226-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025337": {"description": "Questin oxidase-like", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Questin_oxidase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025338": {"description": "Protein of unknown function DUF4244", "go_ids": [], "go_terms": [], "name": "DUF4244", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025339": {"description": "Protein of unknown function DUF4245", "go_ids": [], "go_terms": [], "name": "DUF4245", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025340": {"description": "Protein of unknown function DUF4246", "go_ids": [], "go_terms": [], "name": "DUF4246", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025341": {"description": "Protein of unknown function DUF4247", "go_ids": [], "go_terms": [], "name": "DUF4247", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025342": {"description": "Protein of unknown function DUF4248", "go_ids": [], "go_terms": [], "name": "DUF4248", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025343": {"description": "Domain of unknown function DUF4099", "go_ids": [], "go_terms": [], "name": "DUF4099", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025344": {"description": "Plastid division protein CDP1-like, IMS 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{"description": "Protein of unknown function DUF4260", "go_ids": [], "go_terms": [], "name": "DUF4260", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025357": {"description": "Domain of unknown function DUF4261", "go_ids": [], "go_terms": [], "name": "DUF4261", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025358": {"description": "Protein of unknown function DUF4262", "go_ids": [], "go_terms": [], "name": "DUF4262", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025359": {"description": "Shedu protein SduA, C-terminal", "go_ids": [], "go_terms": [], "name": "SduA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025361": {"description": "Protein of unknown function DUF4265", "go_ids": [], "go_terms": [], "name": "DUF4265", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025362": {"description": "Domain of unknown function DUF4266", "go_ids": [], "go_terms": [], "name": "DUF4266", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025363": {"description": "Protein of unknown function DUF4267", "go_ids": [], "go_terms": [], "name": "DUF4267", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025364": {"description": "Domain of unknown function DUF4268", "go_ids": [], "go_terms": [], "name": "DUF4268", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025365": {"description": "Protein of unknown function DUF4269", "go_ids": [], "go_terms": [], "name": "DUF4269", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025366": {"description": "Outer membrane protein assembly factor BamH", "go_ids": [], "go_terms": [], "name": "BamH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025367": {"description": "Protein of unknown function DUF4271", "go_ids": [], "go_terms": [], "name": "DUF4271", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025368": {"description": "Protein of unknown function DUF4272", "go_ids": [], "go_terms": [], "name": "DUF4272", 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"go_ids": [], "go_terms": [], "name": "DUF4364", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025375": {"description": "Domain of unknown function DUF4365", "go_ids": [], "go_terms": [], "name": "DUF4365", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025376": {"description": "Mobile element protein CD1107-like domain", "go_ids": [], "go_terms": [], "name": "CD1107-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025377": {"description": "Domain of unknown function DUF4367", "go_ids": [], "go_terms": [], "name": "DUF4367", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025378": {"description": "Domain of unknown function DUF4368", "go_ids": [], "go_terms": [], "name": "DUF4368", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025379": {"description": "Protein of unknown function DUF4295", "go_ids": [], "go_terms": [], "name": "DUF4295", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025380": {"description": "Domain of unknown function DUF4369", "go_ids": [], "go_terms": [], "name": "DUF4369", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025381": {"description": "Domain of unknown function DUF4296", "go_ids": [], "go_terms": [], "name": "DUF4296", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025382": {"description": "CD-NTase associated protein 4-like, DNA endonuclease domain", "go_ids": ["GO:0004518"], "go_terms": ["GO:0004518:nuclease activity:F"], "name": "Cap4-like_endonuclease_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025383": {"description": "MrpA C-terminal/MbhD", "go_ids": [], "go_terms": [], "name": "MrpA_C/MbhD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025384": {"description": "Protein of unknown function DUF4298", "go_ids": [], "go_terms": [], "name": "DUF4298", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025385": {"description": "AcfD, middle domain", "go_ids": [], "go_terms": [], "name": "AcfD_M", 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[], "go_terms": [], "name": "DUF4124", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025393": {"description": "Domain of unknown function DUF4301", "go_ids": [], "go_terms": [], "name": "DUF4301", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025394": {"description": "Protein of unknown function DUF4127", "go_ids": [], "go_terms": [], "name": "DUF4127", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025395": {"description": "PPhage tail terminator protein-like", "go_ids": [], "go_terms": [], "name": "Phage_tail_terminator-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025396": {"description": "Protein of unknown function DUF4302", "go_ids": [], "go_terms": [], "name": "DUF4302", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025397": {"description": "Succinate dehydrogenase subunit 5, mitochondrial", "go_ids": ["GO:0006099", "GO:0045273"], "go_terms": ["GO:0006099:tricarboxylic acid cycle:P", "GO:0045273:respiratory chain 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unknown function DUF4391", "go_ids": [], "go_terms": [], "name": "DUF4391", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025504": {"description": "D-glutamate cyclase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "GLUCM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025506": {"description": "Abortive infection alpha", "go_ids": [], "go_terms": [], "name": "Abi_alpha", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025507": {"description": "Domain of unknown function DUF4394", "go_ids": [], "go_terms": [], "name": "DUF4394", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025508": {"description": "Domain of unknown function DUF4395", "go_ids": [], "go_terms": [], "name": "DUF4395", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025509": {"description": "Domain of unknown function DUF4396", "go_ids": [], "go_terms": [], "name": "DUF4396", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025510": {"description": "Domain of unknown function DUF4397", "go_ids": [], "go_terms": [], "name": "DUF4397", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025511": {"description": "Domain of unknown function DUF4398", "go_ids": [], "go_terms": [], "name": "DUF4398", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025512": {"description": "Domain of unknown function DUF4399", "go_ids": [], "go_terms": [], "name": "DUF4399", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025513": {"description": "Domain of unknown function DUF4401", "go_ids": [], "go_terms": [], "name": "DUF4401", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025514": {"description": "Protein of unknown function DUF4402", "go_ids": [], "go_terms": [], "name": "DUF4402", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025515": {"description": "Protein of unknown function DUF4403", "go_ids": [], "go_terms": [], "name": "DUF4403", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025516": {"description": "Protein of unknown function DUF4404", "go_ids": [], "go_terms": [], "name": "DUF4404", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025517": {"description": "Flavinylation-associated cytochrome domain", "go_ids": [], "go_terms": [], "name": "DUF4405", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025518": {"description": "Protein of unknown function DUF4406", "go_ids": [], "go_terms": [], "name": "DUF4406", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025519": {"description": "Protein of unknown function DUF4407", "go_ids": [], "go_terms": [], "name": "DUF4407", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025520": {"description": "Domain of unknown function DUF4408", "go_ids": [], "go_terms": [], "name": "DUF4408", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025521": {"description": "Neprosin activation peptide", "go_ids": [], "go_terms": [], "name": "Neprosin_propep", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025522": {"description": "Protein of unknown function DUF4410", "go_ids": [], "go_terms": [], "name": "DUF4410", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025524": {"description": "Domain of unknown function DUF4412", "go_ids": [], "go_terms": [], "name": "DUF4412", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025525": {"description": "hAT-like transposase-like", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "hAT-like_transposase-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025526": {"description": "DsrC-like domain superfamily", "go_ids": [], "go_terms": [], "name": "DsrC-like_dom_sf", "pathway_ids": ["PWY-7889", "PWY-7888", "PWY-6892", "PWY-5303", "PWY-7904", "PWY-7250", "PWY-7892", "PWY-8164", "PWY-6675", "PWY-8179", "PWY-7891", "PWY-7887"], "pathways": ["PWY-7889:t:tRNA-uridine 2-thiolation (mammalian mitochondria)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6892:t:thiazole component of thiamine diphosphate biosynthesis I", "PWY-5303:t:thiosulfate oxidation II (via tetrathionate)", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-8164:t:bis(guanylyl molybdopterin) cofactor sulfurylation", "PWY-6675:t:sulfur oxidation IV (intracellular sulfur)", "PWY-8179:t:platensimycin biosynthesis", "PWY-7891:t:tRNA-uridine 2-thiolation (yeast mitochondria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation"], "type": "Homologous_superfamily"}, "IPR025527": {"description": "HUWE1/REV1, ubiquitin-binding motif", "go_ids": [], "go_terms": [], "name": "HUWE1/Rev1_UBM", "pathway_ids": ["PWY-7511", "R-MMU-5655862", "R-HSA-6798695", "R-SPO-6798695", "R-GGA-5656121", "R-HSA-5656121", "R-SCE-6798695", "R-MMU-5656169", "R-HSA-5656169", "R-MMU-110312", "R-HSA-983168", "R-HSA-110312", "R-GGA-5655862", "R-HSA-5655862", "R-GGA-353503", "R-GGA-110312", "R-GGA-5656169", "R-MMU-5656121", "R-MMU-983168", "R-SPO-983168", "R-MMU-6798695", "R-SCE-983168", "R-RNO-983168", "R-RNO-6798695"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-110312:r:Translesion synthesis by REV1", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-110312:r:Translesion synthesis by REV1", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-GGA-353503:r:Translesion synthesis by Pol kappa", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Conserved_site"}, "IPR025528": {"description": "BrnA antitoxin of type II toxin-antitoxin system", "go_ids": [], "go_terms": [], "name": "BrnA_antitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025529": {"description": "Protein of unknown function DUF4416", "go_ids": [], "go_terms": [], "name": "DUF4416", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025530": {"description": "Protein of unknown function DUF4417", "go_ids": [], "go_terms": [], "name": "DUF4417", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025531": {"description": "Protein of unknown function DUF4418", "go_ids": [], "go_terms": [], "name": "DUF4418", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025532": {"description": "Glucose-6-phosphate 1-epimerase", "go_ids": [], "go_terms": [], "name": "G6P_1-epimerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025533": {"description": "Protein of unknown function DUF4419", "go_ids": [], "go_terms": [], "name": "DUF4419", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025534": {"description": "Putative PD-(D/E)XK family member (DUF4420)", "go_ids": [], "go_terms": [], "name": "DUF4420", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025535": {"description": "Protein of unknown function DUF4421", "go_ids": [], "go_terms": [], "name": "DUF4421", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025536": {"description": "Domain of unknown function DUF4422", "go_ids": [], "go_terms": [], "name": "DUF4422", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025537": {"description": "Domain of unknown function DUF4423", "go_ids": [], "go_terms": [], "name": "DUF4423", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025538": {"description": "Domain of unknown function DUF4424", "go_ids": [], "go_terms": [], "name": "DUF4424", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025539": {"description": "YdgH protein", "go_ids": [], "go_terms": [], "name": "YdgH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025540": {"description": "Fluoroacetyl-CoA thioesterase", "go_ids": [], "go_terms": [], "name": "FlK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025541": {"description": "Propanediol/glycerol dehydratase, medium subunit", "go_ids": [], "go_terms": [], "name": "Ppandiol/glycerol_DHydtase_msu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025542": {"description": "YacH protein", "go_ids": [], "go_terms": [], "name": "YacH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025543": {"description": "Dodecin-like", "go_ids": [], "go_terms": [], "name": "Dodecin-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR025544": {"description": "YhzD-like protein", "go_ids": [], "go_terms": [], "name": "YhzD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025545": {"description": "YozD-like protein", "go_ids": [], "go_terms": [], "name": "YozD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025546": {"description": "YqzH-like protein", "go_ids": [], "go_terms": [], "name": "YqzH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025547": {"description": "YtzH-like protein", "go_ids": [], "go_terms": [], "name": "YtzH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025548": {"description": "YfkD-like protein", "go_ids": [], "go_terms": [], "name": "YfkD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025549": {"description": "YjzC-like protein", "go_ids": [], "go_terms": [], "name": "YjzC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025550": {"description": "YycC-like protein", "go_ids": [], "go_terms": [], "name": "YycC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025551": {"description": "Immunity protein WapI/YxiJ-like", "go_ids": [], "go_terms": [], "name": "WapI/YxiJ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025552": {"description": "YkyB-like protein", "go_ids": [], "go_terms": [], "name": "YkyB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025553": {"description": "YppF-like protein", "go_ids": [], "go_terms": [], "name": "YppF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025554": {"description": "Domain of unknown function DUF4140", "go_ids": [], "go_terms": [], "name": "DUF4140", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025555": {"description": "YppG-like protein", "go_ids": [], "go_terms": [], "name": "YppG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025557": {"description": "Protein of unknown function DUF4282", "go_ids": [], "go_terms": [], "name": "DUF4282", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025558": {"description": "Domain of unknown function DUF4283", "go_ids": [], "go_terms": [], "name": "DUF4283", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025559": {"description": "Enhanced intracellular survival protein domain", "go_ids": [], "go_terms": [], "name": "Eis_dom", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-9636569"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-9636569:r:Suppression of autophagy"], "type": "Domain"}, "IPR025560": {"description": "Immunity protein 22", "go_ids": [], "go_terms": [], "name": "Imm22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025561": {"description": "Kinase suppressor of RAS, SAM-like domain", "go_ids": [], "go_terms": [], "name": "KSR_SAM-like_dom", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-9649948", "R-HSA-6802946", "R-HSA-6802952", "R-HSA-6802955", "R-HSA-9656223"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Domain"}, "IPR025562": {"description": "Type VI secretion system (T6SS), amidase effector protein 4", "go_ids": [], "go_terms": [], "name": "Tae4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025563": {"description": "Protein of unknown function DUF4286", "go_ids": [], "go_terms": [], "name": "DUF4286", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025564": {"description": "Cyanobacterial aminoacyl-tRNA synthetase, CAAD domain", "go_ids": [], "go_terms": [], "name": "CAAD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025565": {"description": "Domain of unknown function DUF4328", "go_ids": [], "go_terms": [], "name": "DUF4328", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025566": {"description": "Protein of unknown function DUF4331", "go_ids": [], "go_terms": [], "name": "DUF4331", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025567": {"description": "Domain of unknown function DUF4332", "go_ids": [], "go_terms": [], "name": "DUF4332", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025568": {"description": "Domain of unknown function DUF4334", "go_ids": [], "go_terms": [], "name": "DUF4334", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025569": {"description": "Protein of unknown function DUF4335", "go_ids": [], "go_terms": [], "name": "DUF4335", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025570": {"description": "Domain of unknown function DUF4337", "go_ids": [], "go_terms": [], "name": "DUF4337", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025571": {"description": "YqfQ-like protein", "go_ids": [], "go_terms": [], "name": "YqfQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025572": {"description": "YgaB-like protein", "go_ids": [], "go_terms": [], "name": "YgaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025573": {"description": "YwpF-like protein", "go_ids": [], "go_terms": [], "name": "YwpF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025574": {"description": "Nucleoporin FG repeat", "go_ids": [], "go_terms": [], "name": "Nucleoporin_FG_rpt", "pathway_ids": ["R-CEL-159231", "R-SPO-3371453", "R-SPO-159227", "R-CEL-3301854", "R-CEL-159227", "R-SPO-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-DME-4085377", "R-CEL-159230", "R-CEL-3108214", "R-CEL-4551638", "R-DME-4615885", "R-SPO-4085377", "R-DME-3108214", "R-DME-3371453", "R-SPO-159236", "R-SPO-4551638", "R-DME-4551638", "R-DME-159227", "R-CEL-9615933", "R-DME-159230", "R-DME-9615933", "R-DME-3301854", "R-SPO-4570464", "R-CEL-3371453", "R-CEL-159236"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Repeat"}, "IPR025575": {"description": "DpnD/PcfM-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DpnD/PcfM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025576": {"description": "YwiC-like protein", "go_ids": [], "go_terms": [], "name": "YwiC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025577": {"description": "FlxA-like protein", "go_ids": [], "go_terms": [], "name": "FlxA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025578": {"description": "Protein of unknown function DUF4359", "go_ids": [], "go_terms": [], "name": "DUF4359", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025579": {"description": "Domain of unknown function DUF4357", "go_ids": [], "go_terms": [], "name": "DUF4357", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025580": {"description": "Capsid assembly scaffolding protein Gp46", "go_ids": [], "go_terms": [], "name": "Gp46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025581": {"description": "Protein of unknown function DUF4354", "go_ids": [], "go_terms": [], "name": "DUF4354", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025582": {"description": "YARHG domain", "go_ids": [], "go_terms": [], "name": "YARHG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025583": {"description": "HMG-CoA reductase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HMG-CoA_N_dom", "pathway_ids": ["PWY-7524", "PWY-7391", "PWY-922", "PWY-8125", "PWY-6174", "R-SCE-9969896"], "pathways": ["PWY-7524:t:mevalonate pathway III (Thermoplasma)", "PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "PWY-8125:t:mevalonate pathway IV (archaea)", "PWY-6174:t:mevalonate pathway II (haloarchaea)", "R-SCE-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR025584": {"description": "Carbohydrate-binding domain-containing protein Cthe_2159", "go_ids": [], "go_terms": [], "name": "Cthe_2159", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025585": {"description": "Photosystem II Psb27", "go_ids": ["GO:0010206", "GO:0009523", "GO:0010207"], "go_terms": ["GO:0010206:photosystem II repair:P", "GO:0009523:photosystem II:C", "GO:0010207:photosystem II assembly:P"], "name": "PSII_Psb27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025586": {"description": "PcfJ-like protein", "go_ids": [], "go_terms": [], "name": "PcfJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025587": {"description": "Domain of unknown function DUF4351", "go_ids": [], "go_terms": [], "name": "DUF4351", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025588": {"description": "YcxB-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YcxB-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025589": {"description": "Topoisomerase C-terminal repeat", "go_ids": [], "go_terms": [], "name": "Toprim_C_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR025590": {"description": "Domain of unknown function DUF4348", "go_ids": [], "go_terms": [], "name": "DUF4348", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025591": {"description": "RloB-like protein", "go_ids": [], "go_terms": [], "name": "RloB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025592": {"description": "Domain of unknown function DUF4347", "go_ids": [], "go_terms": [], "name": "DUF4347", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025593": {"description": "Growth arrest-specific protein 8 domain", "go_ids": ["GO:0048870", "GO:0031514"], "go_terms": ["GO:0048870:cell motility:P", "GO:0031514:motile cilium:C"], "name": "GAS8_dom", "pathway_ids": ["R-MMU-5635838", "R-HSA-5635838"], "pathways": ["R-MMU-5635838:r:Activation of SMO", "R-HSA-5635838:r:Activation of SMO"], "type": "Domain"}, "IPR025594": {"description": "YebO-like protein", "go_ids": [], "go_terms": [], "name": "YebO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025595": {"description": "Ycf91-like", "go_ids": [], "go_terms": [], "name": "Ycf91-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025596": {"description": "Lipocalin LPS transport optimiser YedD", "go_ids": [], "go_terms": [], "name": "YedD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025597": {"description": "Protein of unknown function DUF4345", "go_ids": [], "go_terms": [], "name": "DUF4345", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025599": {"description": "Regulator of diguanylate cyclase RdcB", "go_ids": [], "go_terms": [], "name": "Rdcb", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025600": {"description": "YccJ-like protein", "go_ids": [], "go_terms": [], "name": "YccJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025601": {"description": "ATP-binding sugar transporter-like protein", "go_ids": [], "go_terms": [], "name": "ATP-bd_sugar_transptr-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025602": {"description": "BCP1 family", "go_ids": [], "go_terms": [], "name": "BCP1_family", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025603": {"description": "YebF/Colicin-M immunity protein", "go_ids": [], "go_terms": [], "name": "YebF/ColM_immunity", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025604": {"description": "Actin cytoskeleton-regulatory complex protein End3", "go_ids": ["GO:0006897", "GO:0007015"], "go_terms": ["GO:0006897:endocytosis:P", "GO:0007015:actin filament organization:P"], "name": "End3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025605": {"description": "OST-HTH/LOTUS domain", "go_ids": [], "go_terms": [], "name": "OST-HTH/LOTUS_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025606": {"description": "NLPC/P60, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NLPC/P60_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025607": {"description": "Large ribosomal subunit protein uL18, C-terminal, eukaryotes", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL18_C_euk", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-GGA-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-GGA-9954716", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-CEL-72689", "R-GGA-975956", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-72689", "R-SCE-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-GGA-9954714", "R-SCE-1799339", "R-DDI-9954709", "R-DME-1799339", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-GGA-9954709", "R-BTA-9954714", "R-GGA-975957", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-GGA-1799339", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR025608": {"description": "TcpE family", "go_ids": [], "go_terms": [], "name": "TcpE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025609": {"description": "Lsm14-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Lsm14-like_N", "pathway_ids": ["R-MMU-430039", "R-DME-430039", "R-DRE-430039", "R-HSA-430039"], "pathways": ["R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DME-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR025610": {"description": "Transcription factor MYC/MYB, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MYC/MYB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025611": {"description": "YobH-like protein", "go_ids": [], "go_terms": [], "name": "YobH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025612": {"description": "YqjK-like protein", "go_ids": [], "go_terms": [], "name": "YqjK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025613": {"description": "YlbE-like protein", "go_ids": [], "go_terms": [], "name": "YlbE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025614": {"description": "Cell morphogenesis protein N-terminal", "go_ids": [], "go_terms": [], "name": "Cell_morpho_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025615": {"description": "TILa domain", "go_ids": [], "go_terms": [], "name": "TILa_dom", "pathway_ids": ["R-MMU-163125", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Domain"}, "IPR025616": {"description": "YpjP-like protein", "go_ids": [], "go_terms": [], "name": "YpjP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025617": {"description": "YqzL-like protein", "go_ids": [], "go_terms": [], "name": "YqzL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025618": {"description": "YtpI-like protein", "go_ids": [], "go_terms": [], "name": "YtpI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025619": {"description": "YlzJ-like protein", "go_ids": [], "go_terms": [], "name": "YlzJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025620": {"description": "YlaH-like protein", "go_ids": [], "go_terms": [], "name": "YlaH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025621": {"description": "YoqO-like protein", "go_ids": [], "go_terms": [], "name": "YoqO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025622": {"description": "Forespore factor SpoIIIL", "go_ids": [], "go_terms": [], "name": "SpoIIIL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025623": {"description": "YusW-like protein", "go_ids": [], "go_terms": [], "name": "YusW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025624": {"description": "PcfK-like domain", "go_ids": [], "go_terms": [], "name": "PcfK", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025625": {"description": "YuzL-like protein", "go_ids": [], "go_terms": [], "name": "YuzL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025626": {"description": "YyzF-like protein", "go_ids": [], "go_terms": [], "name": "YyzF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025627": {"description": "YfzA-like protein", "go_ids": [], "go_terms": [], "name": "YfzA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025629": {"description": "Protein of unknown function DUF4287", "go_ids": [], "go_terms": [], "name": "DUF4287", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025630": {"description": "Protein of unknown function DUF4288", "go_ids": [], "go_terms": [], "name": "DUF4288", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025631": {"description": "Putative porin-10", "go_ids": [], "go_terms": [], "name": "Porin_10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025632": {"description": "Protein of unknown function DUF4290", "go_ids": [], "go_terms": [], "name": "DUF4290", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025633": {"description": "Protein of unknown function DUF4291", "go_ids": [], "go_terms": [], "name": "DUF4291", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025634": {"description": "Protein of unknown function DUF4292", "go_ids": [], "go_terms": [], "name": "DUF4292", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025635": {"description": "Protein of unknown function DUF4293", "go_ids": [], "go_terms": [], "name": "DUF4293", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025636": {"description": "Protein of unknown function DUF4294", "go_ids": [], "go_terms": [], "name": "DUF4294", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025637": {"description": "Domain of unknown function DUF4333", "go_ids": [], "go_terms": [], "name": "DUF4333", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025638": {"description": "Protein of unknown function DUF4336", "go_ids": [], "go_terms": [], "name": "DUF4336", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025639": {"description": "Druantia protein DruA", "go_ids": [], "go_terms": [], "name": "DruA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025640": {"description": "GYF domain 2", "go_ids": [], "go_terms": [], "name": "GYF_2", "pathway_ids": ["R-HSA-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR025641": {"description": "Domain of unknown function DUF4340", "go_ids": [], "go_terms": [], "name": "DUF4340", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025642": {"description": "Domain of unknown function DUF4342", "go_ids": [], "go_terms": [], "name": "DUF4342", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025643": {"description": "ATP-grasp domain, R2K clade family 3", "go_ids": [], "go_terms": [], "name": "R2K_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025644": {"description": "Putative metallopeptidase", "go_ids": [], "go_terms": [], "name": "DUF4344", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025645": {"description": "Domain of unknown function DUF4349", "go_ids": [], "go_terms": [], "name": "DUF4349", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025646": {"description": "Domain of unknown function DUF4350", "go_ids": [], "go_terms": [], "name": "DUF4350", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025647": {"description": "Putative component of 'biosynthetic module'", "go_ids": [], "go_terms": [], "name": "YceG_bac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025648": {"description": "Protein of unknown function DUF4358", "go_ids": [], "go_terms": [], "name": "DUF4358", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025649": {"description": "Protein of unknown function DUF4360", "go_ids": [], "go_terms": [], "name": "DUF4360", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025650": {"description": "Alkyldihydroxyacetonephosphate synthase", "go_ids": ["GO:0008609", "GO:0008610"], "go_terms": ["GO:0008609:alkylglycerone-phosphate synthase activity:F", "GO:0008610:lipid biosynthetic process:P"], "name": "Alkyl-DHAP_Synthase", "pathway_ids": ["PWY-7782", "R-RNO-9033241", "R-DME-9033241", "R-HSA-75896", "R-CEL-75896", "R-RNO-75896", "R-HSA-9033500", "R-MMU-9033241", "R-HSA-9033241", "R-DME-75896", "R-MMU-75896"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "R-RNO-9033241:r:Peroxisomal protein import", "R-DME-9033241:r:Peroxisomal protein import", "R-HSA-75896:r:Plasmalogen biosynthesis", "R-CEL-75896:r:Plasmalogen biosynthesis", "R-RNO-75896:r:Plasmalogen biosynthesis", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-75896:r:Plasmalogen biosynthesis", "R-MMU-75896:r:Plasmalogen biosynthesis"], "type": "Family"}, "IPR025652": {"description": "Acyl-CoA thioesterase 2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TesB_C", "pathway_ids": ["PWY-735", "PWY-7913", "PWY-5148", "R-SCE-390247", "R-SCE-193368", "R-SCE-389887", "R-SCE-2046106", "R-SCE-9033241"], "pathways": ["PWY-735:t:jasmonic acid biosynthesis", "PWY-7913:t:firefly bioluminescence", "PWY-5148:t:acyl-CoA hydrolysis", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-SCE-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SCE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SCE-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR025654": {"description": "Peroxisome biogenesis factor 2/10", "go_ids": ["GO:0005778", "GO:0008270", "GO:0007031", "GO:0016558"], "go_terms": ["GO:0005778:peroxisomal membrane:C", "GO:0008270:zinc ion binding:F", "GO:0007031:peroxisome organization:P", "GO:0016558:protein import into peroxisome matrix:P"], "name": "PEX2/10", "pathway_ids": ["PWY-7511", "R-MMU-8866654", "R-HSA-8866654", "R-RNO-9033241", "R-SPO-9033241", "R-SCE-9033241", "R-RNO-9603798", "R-MMU-9603798", "R-MMU-9033241", "R-RNO-8866654", "R-DDI-9033241", "R-HSA-9603798", "R-HSA-9033241", "R-DDI-8866654"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-SCE-9033241:r:Peroxisomal protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Family"}, "IPR025655": {"description": "Peroxisomal membrane protein 14", "go_ids": ["GO:0005515", "GO:0005778", "GO:0016560"], "go_terms": ["GO:0005515:protein binding:F", "GO:0005778:peroxisomal membrane:C", "GO:0016560:protein import into peroxisome matrix, docking:P"], "name": "PEX14", "pathway_ids": ["R-HSA-8866654", "R-MMU-8866654", "R-SCE-9603798", "R-SPO-9033241", "R-RNO-9033241", "R-SPO-9603798", "R-SCE-9033241", "R-RNO-9603798", "R-DDI-9603798", "R-MMU-9603798", "R-MMU-9033241", "R-RNO-8866654", "R-DDI-9033241", "R-HSA-9603798", "R-HSA-9033241", "R-DDI-8866654"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-9033241:r:Peroxisomal protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Family"}, "IPR025657": {"description": "RadC-like JAB domain", "go_ids": [], "go_terms": [], "name": "RadC_JAB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025658": {"description": "Cyclophilin TM1367-like domain", "go_ids": [], "go_terms": [], "name": "Cyclophilin_TM1367", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025659": {"description": "Tubby-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Tubby-like_C", "pathway_ids": ["R-MMU-8951664", "R-CEL-5610787", "R-HSA-5610787", "R-MMU-5610787", "R-HSA-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-CEL-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-8951664:r:Neddylation"], "type": "Homologous_superfamily"}, "IPR025663": {"description": "A-kinase anchor protein 28kDa", "go_ids": [], "go_terms": [], "name": "AKAP_28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025664": {"description": "Stage III sporulation protein AC/AD family", "go_ids": [], "go_terms": [], "name": "Spore_III_AC/AD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025665": {"description": "Outer membrane protein, beta-barrel domain 2", "go_ids": [], "go_terms": [], "name": "Beta-barrel_OMP_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025667": {"description": "SprB repeat", "go_ids": [], "go_terms": [], "name": "SprB_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR025668": {"description": "Transposase DDE domain", "go_ids": [], "go_terms": [], "name": "Tnp_DDE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025669": {"description": "AAA domain", "go_ids": [], "go_terms": [], "name": "AAA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025670": {"description": "Fox-1 C-terminal domain", "go_ids": [], "go_terms": [], "name": "Fox-1_C_dom", "pathway_ids": ["R-RNO-6803529", "R-HSA-6803529", "R-HSA-9768919", "R-HSA-9022707"], "pathways": ["R-RNO-6803529:r:FGFR2 alternative splicing", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9022707:r:MECP2 regulates transcription factors"], "type": "Domain"}, "IPR025671": {"description": "Protein of unknown function with HXXEE motif", "go_ids": [], "go_terms": [], "name": "HXXEE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025672": {"description": "Sigma factor regulator C-terminal domain", "go_ids": [], "go_terms": [], "name": "Sigma_reg_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025673": {"description": "Protein of unknown function with PCYCGC motif", "go_ids": [], "go_terms": [], "name": "PCYCGC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025674": {"description": "Immunity protein Imm6", "go_ids": [], "go_terms": [], "name": "Imm6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025675": {"description": "Immunity protein Imm5", "go_ids": [], "go_terms": [], "name": "Imm5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025676": {"description": "Clr5 domain", "go_ids": [], "go_terms": [], "name": "Clr5_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025677": {"description": "OST-HTH associated domain", "go_ids": [], "go_terms": [], "name": "OST-HTH-assoc_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025678": {"description": "Immunity protein Imm3", "go_ids": [], "go_terms": [], "name": "Imm3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025679": {"description": "Immunity protein Imm2", "go_ids": [], "go_terms": [], "name": "Imm2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025680": {"description": "Double-stranded DNA deaminase immunity protein DddI", "go_ids": [], "go_terms": [], "name": "DddI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025681": {"description": "Phage phiEco32-like COOH-NH2 ligase-type 2", "go_ids": [], "go_terms": [], "name": "COOH-NH2_lig", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025682": {"description": "CpXC domain", "go_ids": [], "go_terms": [], "name": "CpXC_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025683": {"description": "Protein beta", "go_ids": [], "go_terms": [], "name": "Protein_beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025684": {"description": "Gliding motility protein SprA N-terminal domain", "go_ids": [], "go_terms": [], "name": "SprA_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025685": {"description": "YoaP-like domain", "go_ids": [], "go_terms": [], "name": "YoaP-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025686": {"description": "Glucosyl transferase II-like", "go_ids": [], "go_terms": [], "name": "Glucos_trans_II-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025687": {"description": "C4-type zinc-finger of DNA polymerase delta", "go_ids": [], "go_terms": [], "name": "Znf-C4pol", "pathway_ids": ["R-CEL-69091", "R-RNO-174437", "R-HSA-174414", "R-SPO-5656169", "R-SPO-5656121", "R-HSA-5696397", "R-MMU-174417", "R-DDI-6782210", "R-CEL-69166", "R-RNO-110314", "R-DME-5656121", "R-HSA-5655862", "R-RNO-69183", "R-MMU-110314", "R-HSA-174417", "R-CEL-110314", "R-MMU-174414", "R-RNO-5696397", "R-SPO-69091", "R-DME-5655862", "R-DME-69183", "R-MMU-174437", "R-RNO-5656169", "R-HSA-5656121", "R-MMU-5358606", "R-SPO-69166", "R-MMU-5358565", "R-RNO-6782210", "R-SCE-69183", "R-MMU-5651801", "R-DDI-69183", "R-CEL-6782210", "R-HSA-110312", "R-MMU-69183", "R-SPO-110314", "R-SCE-69166", "R-CEL-6782135", "R-MMU-6782210", "R-CEL-5651801", "R-SCE-110312", "R-MMU-174411", "R-MMU-5696397", "R-RNO-174414", "R-HSA-110314", "R-SPO-5651801", "R-DDI-6782135", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5655862", "R-HSA-5358606", "R-MMU-110312", "R-SPO-110312", "R-RNO-69166", "R-CEL-69183", "R-DME-110312", "R-HSA-6782210", "R-CEL-5656169", "R-HSA-5656169", "R-RNO-174411", "R-MMU-5696400", "R-MMU-5655862", "R-RNO-5358606", "R-HSA-2564830", "R-SPO-5696397", "R-RNO-5358565", "R-DDI-69091", "R-RNO-6782135", "R-SPO-69183", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-HSA-174411", "R-HSA-69166", "R-CEL-5696397", "R-DDI-69166", "R-RNO-69091", "R-RNO-5685942", "R-MMU-5656121", "R-SPO-5696400", "R-SPO-6782210", "R-HSA-69183", "R-MMU-69166", "R-RNO-5696400", "R-RNO-174417", "R-HSA-5696400", "R-HSA-5358565", "R-HSA-69091", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-CEL-69091:r:Polymerase switching", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-5656121:r:Translesion synthesis by POLI", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SPO-69091:r:Polymerase switching", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110312:r:Translesion synthesis by REV1", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-110312:r:Translesion synthesis by REV1", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-6782135:r:Dual incision in TC-NER", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-69091:r:Polymerase switching", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-69166:r:Removal of the Flap Intermediate", "R-RNO-69091:r:Polymerase switching", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-69091:r:Polymerase switching", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Domain"}, "IPR025688": {"description": "PGDYG protein", "go_ids": [], "go_terms": [], "name": "PGDYG_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025689": {"description": "Sporulation protein YtrH", "go_ids": [], "go_terms": [], "name": "Spore_YtrH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025690": {"description": "Methyltransferase, putative", "go_ids": [], "go_terms": [], "name": "Methyltransf_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025691": {"description": "GspL periplasmic domain", "go_ids": [], "go_terms": [], "name": "GspL_pp_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025692": {"description": "Mechanosensitive ion channel inner membrane domain 1", "go_ids": [], "go_terms": [], "name": "MscS_IM_dom1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025693": {"description": "Glycine-zipper-containing OmpA-like membrane domain", "go_ids": [], "go_terms": [], "name": "Gly-zipper_OmpA-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025694": {"description": "Mitochondrial splicing apparatus component MNE1", "go_ids": ["GO:0000372", "GO:1990904"], "go_terms": ["GO:0000372:Group I intron splicing:P", "GO:1990904:ribonucleoprotein complex:C"], "name": "MNE1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025695": {"description": "DoxX-like family", "go_ids": [], "go_terms": [], "name": "DoxX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025696": {"description": "Exosome RNA helicase MTR4-like, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "Beta-barrel_MTR4", "pathway_ids": ["R-MMU-9930044", "R-HSA-72163", "R-MMU-6791226", "R-HSA-9930044", "R-SCE-6791226", "R-SPO-429958", "R-HSA-6791226", "R-HSA-9843970", "R-HSA-390471", "R-MMU-72163", "R-MMU-429958", "R-CEL-9930044", "R-CEL-6791226", "R-HSA-429958", "R-CEL-72163", "R-SPO-9930044", "R-SPO-72163", "R-SPO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9930044:r:Nuclear RNA decay", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR025697": {"description": "CLU domain", "go_ids": [], "go_terms": [], "name": "CLU_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025698": {"description": "2TM domain", "go_ids": [], "go_terms": [], "name": "2TM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025699": {"description": "ABC-2 membrane transporter-like", "go_ids": [], "go_terms": [], "name": "ABC2_memb-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025700": {"description": "L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase", "go_ids": [], "go_terms": [], "name": "Lys/Orn_oxygenase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025701": {"description": "Ubiquitin-conjugating enzyme, E2, family E", "go_ids": [], "go_terms": [], "name": "UBQ-conjugat_E2_E", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025702": {"description": "Aliphatic aldoxime/phenylacetaldoxime dehydratase", "go_ids": [], "go_terms": [], "name": "OXD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025703": {"description": "Bifunctional protein PutA", "go_ids": ["GO:0006355", "GO:0003842", "GO:0003700", "GO:0004657", "GO:0006562"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003842:L-glutamate gamma-semialdehyde dehydrogenase activity:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0004657:proline dehydrogenase activity:F", "GO:0006562:L-proline catabolic process:P"], "name": "Bifunct_PutA", "pathway_ids": ["PWY-6922", "PWY-5737", "PWY-6853"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-5737:t:(5R)-carbapenem carboxylate biosynthesis", "PWY-6853:t:ethene biosynthesis II (microbes)"], "type": "Family"}, "IPR025704": {"description": "E3 ubiquitin ligase UBR4, C-terminal", "go_ids": [], "go_terms": [], "name": "E3_Ub_ligase_UBR4_C", "pathway_ids": ["R-DDI-6798695", "R-DDI-983168", "R-HSA-6798695", "R-DME-983168", "R-HSA-9920588", "R-DME-6798695", "R-CEL-6798695", "R-MMU-983168", "R-MMU-6798695", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR025705": {"description": "Beta-hexosaminidase", "go_ids": ["GO:0005975", "GO:0004563"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0004563:beta-N-acetylhexosaminidase activity:F"], "name": "GH20", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-7883", "R-DDI-9840310", "R-HSA-2024101", "R-HSA-6798695", "R-MMU-9840310", "R-DDI-6798695", "R-RNO-9840310", "R-CEL-2024101", "R-HSA-9840310", "R-CEL-6798695", "R-HSA-2022857", "R-HSA-3656234", "R-HSA-2160916", "R-MMU-2160916", "R-HSA-3656248", "R-CEL-2160916", "R-RNO-2022857", "R-MMU-2022857", "R-BTA-9840310", "R-CEL-2022857", "R-CEL-9840310", "R-RNO-2024101", "R-BTA-2160916", "R-DDI-2022857", "R-MMU-2024101", "R-MMU-6798695", "R-DDI-2160916", "R-DDI-2024101", "R-RNO-2160916", "R-BTA-2024101", "R-RNO-6798695", "R-BTA-2022857"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-7883:t:peptidoglycan recycling II", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-CEL-2024101:r:CS/DS degradation", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-2022857:r:Keratan sulfate degradation", "R-HSA-3656234:r:Defective HEXA causes GM2G1 (Hyaluronan metabolism)", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-3656248:r:Defective HEXB causes GM2G2 (Hyaluronan metabolism)", "R-CEL-2160916:r:Hyaluronan degradation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-CEL-2022857:r:Keratan sulfate degradation", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-RNO-2024101:r:CS/DS degradation", "R-BTA-2160916:r:Hyaluronan degradation", "R-DDI-2022857:r:Keratan sulfate degradation", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-2160916:r:Hyaluronan degradation", "R-DDI-2024101:r:CS/DS degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-2022857:r:Keratan sulfate degradation"], "type": "Family"}, "IPR025706": {"description": "Endo-alpha-N-acetylgalactosaminidase", "go_ids": ["GO:0033926"], "go_terms": ["GO:0033926:endo-alpha-N-acetylgalactosaminidase activity:F"], "name": "Endoa_GalNAc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025707": {"description": "Predicted DNA-binding protein with PD1-like DNA-binding motif", "go_ids": [], "go_terms": [], "name": "DNA_bp_PD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025708": {"description": "Heat shock protein 15", "go_ids": ["GO:0034605", "GO:0003727", "GO:0003677", "GO:0043023"], "go_terms": ["GO:0034605:cellular response to heat:P", "GO:0003727:single-stranded RNA binding:F", "GO:0003677:DNA binding:F", "GO:0043023:ribosomal large subunit binding:F"], "name": "HSP15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025709": {"description": "Leucyl-tRNA synthetase, editing domain", "go_ids": ["GO:0002161", "GO:0006418"], "go_terms": ["GO:0002161:aminoacyl-tRNA deacylase activity:F", "GO:0006418:tRNA aminoacylation for protein translation:P"], "name": "Leu_tRNA-synth_edit", "pathway_ids": ["R-HSA-379726"], "pathways": ["R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Domain"}, "IPR025710": {"description": "L-cysteine S-thiosulfotransferase subunit SoxA", "go_ids": ["GO:0016669", "GO:0070069", "GO:0019417", "GO:0009055", "GO:0020037"], "go_terms": ["GO:0016669:oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor:F", "GO:0070069:cytochrome complex:C", "GO:0019417:sulfur oxidation:P", "GO:0009055:electron transfer activity:F", "GO:0020037:heme binding:F"], "name": "SoxA", "pathway_ids": ["PWY-6677", "PWY-5296"], "pathways": ["PWY-6677:t:thiosulfate oxidation IV (multienzyme complex)", "PWY-5296:t:thiosulfate oxidation III (multienzyme complex)"], "type": "Family"}, "IPR025711": {"description": "PepSY domain", "go_ids": [], "go_terms": [], "name": "PepSY", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025712": {"description": "Nucleoporin Nup54, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "Nup54_alpha-helical_dom", "pathway_ids": ["R-MMU-4551638", "R-MMU-4085377", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-HSA-4570464", "R-DME-4615885", "R-RNO-159236", "R-SPO-4085377", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-SPO-159236", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-HSA-6784531", "R-MMU-3301854", "R-DME-4551638", "R-HSA-4085377", "R-HSA-168325", "R-DME-159227", "R-MMU-170822", "R-RNO-159227", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-RNO-4551638", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-RNO-4085377", "R-HSA-9615933", "R-SPO-4570464", "R-RNO-170822", "R-DME-159230", "R-DME-3301854", "R-RNO-159231", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-RNO-4615885", "R-SPO-3371453", "R-HSA-180910", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-3108214", "R-SPO-159227", "R-HSA-191859", "R-HSA-9705671", "R-SPO-159231", "R-RNO-3301854", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-MMU-159230", "R-HSA-159227", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230"], "pathways": ["R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-191859:r:snRNP Assembly", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA"], "type": "Domain"}, "IPR025713": {"description": "Motility protein B-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MotB-like_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025714": {"description": "Methyltransferase domain", "go_ids": [], "go_terms": [], "name": "Methyltranfer_dom", "pathway_ids": ["R-SCE-8876725", "R-HSA-8876725", "R-HSA-9854311", "R-DRE-8876725", "R-RNO-156581", "R-HSA-156581", "R-MMU-389661", "R-DRE-9854311", "R-SPO-8876725", "R-MMU-156581", "R-MMU-8876725"], "pathways": ["R-SCE-8876725:r:Protein methylation", "R-HSA-8876725:r:Protein methylation", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-8876725:r:Protein methylation", "R-RNO-156581:r:Methylation", "R-HSA-156581:r:Methylation", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-8876725:r:Protein methylation", "R-MMU-156581:r:Methylation", "R-MMU-8876725:r:Protein methylation"], "type": "Domain"}, "IPR025715": {"description": "RNA annealing protein YRA2, C-terminal", "go_ids": [], "go_terms": [], "name": "YRA2_C", "pathway_ids": ["R-BTA-159230", "R-SPO-159236", "R-SPO-159227", "R-MMU-72163", "R-SPO-159231", "R-MMU-73856", "R-XTR-159236", "R-BTA-73856", "R-XTR-72163", "R-HSA-73856", "R-HSA-72187", "R-BTA-159227", "R-MMU-159236", "R-MMU-159230", "R-RNO-73856", "R-HSA-159230", "R-HSA-72163", "R-MMU-159227", "R-HSA-159227", "R-HSA-159231", "R-MMU-72187", "R-RNO-159236", "R-BTA-159236", "R-BTA-159231", "R-HSA-159236", "R-SPO-72163", "R-HSA-9918481", "R-MMU-159231", "R-BTA-72163"], "pathways": ["R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR025716": {"description": "Post-transcriptional regulator", "go_ids": [], "go_terms": [], "name": "Post-transcriptional_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025717": {"description": "Histone deacetylase complex subunit SAP30 zinc-finger", "go_ids": [], "go_terms": [], "name": "SAP30_zn-finger", "pathway_ids": ["R-XTR-3214815", "R-HSA-427413", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-DRE-3214815", "R-DME-3214815"], "pathways": ["R-XTR-3214815:r:HDACs deacetylate histones", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DRE-3214815:r:HDACs deacetylate histones", "R-DME-3214815:r:HDACs deacetylate histones"], "type": "Domain"}, "IPR025718": {"description": "Histone deacetylase complex subunit SAP30, Sin3 binding domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "SAP30_Sin3-bd", "pathway_ids": ["R-XTR-3214815", "R-HSA-427413", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-DRE-3214815", "R-SCE-3214815", "R-DME-3214815"], "pathways": ["R-XTR-3214815:r:HDACs deacetylate histones", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DRE-3214815:r:HDACs deacetylate histones", "R-SCE-3214815:r:HDACs deacetylate histones", "R-DME-3214815:r:HDACs deacetylate histones"], "type": "Domain"}, "IPR025719": {"description": "Myelin gene regulatory factor C-terminal domain 2", "go_ids": [], "go_terms": [], "name": "MYRF_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025720": {"description": "ECF transporter, Riboflavin transporter RibU", "go_ids": ["GO:0032218", "GO:0005886", "GO:0032217"], "go_terms": ["GO:0032218:riboflavin transport:P", "GO:0005886:plasma membrane:C", "GO:0032217:riboflavin transmembrane transporter activity:F"], "name": "RibU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025721": {"description": "Exosome complex component, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Exosome_cplx_N_dom", "pathway_ids": ["R-BTA-450604", "R-MMU-450385", "R-HSA-9930044", "R-BTA-450385", "R-CEL-450385", "R-MMU-429958", "R-SPO-9930044", "R-SCE-450385", "R-SCE-429958", "R-HSA-380994", "R-SCE-6791226", "R-CEL-429958", "R-CEL-6791226", "R-HSA-429958", "R-SPO-429958", "R-MMU-9930044", "R-MMU-6791226", "R-BTA-429958", "R-BTA-6791226", "R-BTA-450513", "R-SCE-450513", "R-CEL-450513", "R-BTA-9930044", "R-HSA-450385", "R-MMU-450513", "R-HSA-6791226", "R-MMU-450604", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-SPO-6791226"], "pathways": ["R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-BTA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-9930044:r:Nuclear RNA decay", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR025722": {"description": "Bacterial transcriptional repressor TetR", "go_ids": [], "go_terms": [], "name": "TetR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025723": {"description": "ArsA/GET3, Anion-transporting ATPase-like domain", "go_ids": [], "go_terms": [], "name": "ArsA/GET3_ATPase-like", "pathway_ids": ["R-HSA-9609523"], "pathways": ["R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Domain"}, "IPR025724": {"description": "GAG-pre-integrase domain", "go_ids": [], "go_terms": [], "name": "GAG-pre-integrase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025725": {"description": "E3 ubiquitin-protein ligase SopA, catalytic domain", "go_ids": ["GO:0004842", "GO:0016567"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F", "GO:0016567:protein ubiquitination:P"], "name": "SopA_cat", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR025726": {"description": "E3 ubiquitin ligase SopA-like central domain", "go_ids": [], "go_terms": [], "name": "SopA-like_central", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR025727": {"description": "YbfN-like lipoprotein", "go_ids": [], "go_terms": [], "name": "YbfN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025728": {"description": "YsaB-like lipoprotein", "go_ids": [], "go_terms": [], "name": "YsaB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025729": {"description": "Acidic protein MsyB", "go_ids": [], "go_terms": [], "name": "MsyB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025730": {"description": "Biofilm regulator BssS", "go_ids": [], "go_terms": [], "name": "Biofilm_BssS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025731": {"description": "YecR-like lipoprotein", "go_ids": [], "go_terms": [], "name": "YecR-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025732": {"description": "MarB protein", "go_ids": [], "go_terms": [], "name": "MarB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025733": {"description": "Purple acid phosphatase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PAPs_C", "pathway_ids": ["PWY-6348"], "pathways": ["PWY-6348:t:phosphate acquisition"], "type": "Domain"}, "IPR025734": {"description": "EspG family", "go_ids": [], "go_terms": [], "name": "EspG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025735": {"description": "RIP homotypic interaction motif", "go_ids": [], "go_terms": [], "name": "RHIM", "pathway_ids": ["R-HSA-1606341", "R-HSA-168164", "R-HSA-5602571", "R-HSA-9828211", "R-HSA-9824878", "R-MMU-937072", "R-MMU-166166", "R-HSA-1606322", "R-MMU-5357956", "R-MMU-5689896", "R-HSA-9686347", "R-HSA-936964", "R-MMU-5689880", "R-MMU-5213460", "R-RNO-3295583", "R-HSA-168927", "R-MMU-3371378", "R-MMU-5218900", "R-MMU-975163", "R-HSA-937041", "R-RNO-5213460", "R-HSA-937072", "R-HSA-9692913", "R-MMU-9824878", "R-MMU-936964", "R-MMU-75893", "R-RNO-937041", "R-MMU-5357786", "R-MMU-140534", "R-RNO-2562578", "R-HSA-9013973", "R-HSA-5675482", "R-MMU-5675482", "R-HSA-5602566", "R-HSA-9679191", "R-HSA-166166", "R-HSA-1810476", "R-HSA-5213460", "R-MMU-69416", "R-HSA-2562578", "R-MMU-5357905", "R-HSA-9692916", "R-HSA-3134975", "R-HSA-9014325", "R-RNO-5675482", "R-MMU-2562578", "R-HSA-140534", "R-MMU-937041", "R-HSA-9013957", "R-MMU-3295583", "R-HSA-975163", "R-HSA-3295583"], "pathways": ["R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-1606322:r:ZBP1(DAI) mediated induction of type I IFNs", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-3295583:r:TRP channels", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-MMU-3371378:r:Regulation by c-FLIP", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-75893:r:TNF signaling", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-HSA-5602566:r:TICAM1 deficiency - HSE", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-69416:r:Dimerization of procaspase-8", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-MMU-3295583:r:TRP channels", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-3295583:r:TRP channels"], "type": "Binding_site"}, "IPR025736": {"description": "PucR C-terminal helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "PucR_C-HTH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025737": {"description": "Functional amyloid transporter FapF", "go_ids": [], "go_terms": [], "name": "FApF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025738": {"description": "Aerotolerance-related protein BatD", "go_ids": [], "go_terms": [], "name": "BatD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025739": {"description": "Centrosome-associated, FAM110, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FAM110_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025740": {"description": "FAM110", "go_ids": [], "go_terms": [], "name": "FAM110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025741": {"description": "Centrosome-associated, FAM110, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FAM110_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025742": {"description": "Cleavage stimulation factor subunit 2, hinge domain", "go_ids": [], "go_terms": [], "name": "CSTF2_hinge", "pathway_ids": ["R-HSA-9770562", "R-MMU-9770562", "R-HSA-6784531", "R-MMU-77595", "R-HSA-73856", "R-MMU-73856", "R-BTA-73856", "R-HSA-72187", "R-HSA-77595", "R-SPO-9770562", "R-MMU-72187", "R-BTA-9770562", "R-HSA-9918481", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR025743": {"description": "Type VI secretion system component TssM1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TssM1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025744": {"description": "Ribosomally synthesised peptide in Streptomyces", "go_ids": [], "go_terms": [], "name": "Rbsml_synth_pep_Strp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025745": {"description": "Restriction system protein Mrr-like N-terminal domain", "go_ids": [], "go_terms": [], "name": "Mrr-like_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025746": {"description": "Type 4 fimbrial biogenesis protein PilX, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PilX_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025747": {"description": "ThiC-associated domain", "go_ids": [], "go_terms": [], "name": "ThiC-associated_dom", "pathway_ids": ["PWY-6890"], "pathways": ["PWY-6890:t:4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I"], "type": "Domain"}, "IPR025748": {"description": "PrcB C-terminal domain", "go_ids": [], "go_terms": [], "name": "PrcB_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025749": {"description": "Sphingomyelin synthase-like domain", "go_ids": [], "go_terms": [], "name": "Sphingomyelin_synth-like_dom", "pathway_ids": ["R-RNO-1660661", "R-CEL-1660661", "R-HSA-1660661", "R-DME-1660661", "R-MMU-1660661"], "pathways": ["R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Domain"}, "IPR025750": {"description": "DPF1-3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DPF1-3_N", "pathway_ids": ["R-MMU-9933946", "R-MMU-9934037", "R-HSA-9845323", "R-HSA-9933937", "R-CEL-9933937", "R-MMU-9933937", "R-CEL-9933946", "R-CEL-9934037", "R-HSA-9933946", "R-RNO-9933937", "R-HSA-9824585", "R-HSA-9934037"], "pathways": ["R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-CEL-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-RNO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "type": "Domain"}, "IPR025751": {"description": "RsbT co-antagonist protein RsbRD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RsbRD_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025752": {"description": "High pH protein family", "go_ids": ["GO:0005783"], "go_terms": ["GO:0005783:endoplasmic reticulum:C"], "name": "HPH_family", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025753": {"description": "AAA-type ATPase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AAA_N_dom", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR025754": {"description": "TRC8-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TRC8_N_dom", "pathway_ids": ["PWY-7511", "R-HSA-901032"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)"], "type": "Domain"}, "IPR025755": {"description": "Large ribosomal subunit protein uL4, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ribos_uL4_C_dom", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-RNO-975957", "R-BTA-156827", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR025756": {"description": "MYB-CC type transcription factor, LHEQLE-containing domain", "go_ids": [], "go_terms": [], "name": "Myb_CC_LHEQLE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025757": {"description": "Ternary complex factor MIP1, leucine-zipper", "go_ids": [], "go_terms": [], "name": "MIP1_Leuzipper", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025758": {"description": "Fic/DOC N-terminal", "go_ids": [], "go_terms": [], "name": "Fic/DOC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025773": {"description": "Arterivirus papain-like cysteine protease beta (PCPbeta) domain", "go_ids": ["GO:0008234"], "go_terms": ["GO:0008234:cysteine-type peptidase activity:F"], "name": "AV_PCPbeta", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR025775": {"description": "Birnavirus VP4 protease domain", "go_ids": [], "go_terms": [], "name": "Birna_VP4_Prtase_dom", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR025789": {"description": "Histone-lysine N-methyltransferase DOT1 domain", "go_ids": ["GO:0031151"], "go_terms": ["GO:0031151:histone H3K79 methyltransferase activity:F"], "name": "DOT1_dom", "pathway_ids": ["R-CEL-3214841", "R-MMU-3214841", "R-HSA-3214841"], "pathways": ["R-CEL-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines"], "type": "Domain"}, "IPR025799": {"description": "Protein arginine N-methyltransferase", "go_ids": ["GO:0016274", "GO:0018216"], "go_terms": ["GO:0016274:protein-arginine N-methyltransferase activity:F", "GO:0018216:peptidyl-arginine methylation:P"], "name": "Arg_MeTrfase", "pathway_ids": ["R-HSA-1989781", "R-SCE-8876725", "R-HSA-8876725", "R-XTR-8936459", "R-HSA-2151201", "R-HSA-191859", "R-XTR-3214858", "R-XTR-9018519", "R-RNO-3214858", "R-HSA-8936459", "R-DRE-8936459", "R-CEL-8936459", "R-RNO-9009391", "R-MMU-9009391", "R-XTR-9009391", "R-DRE-400206", "R-RNO-9018519", "R-HSA-3214858", "R-HSA-1368108", "R-RNO-8936459", "R-BTA-3214858", "R-DME-3214858", "R-HSA-9933387", "R-DDI-9018519", "R-HSA-9707564", "R-BTA-8936459", "R-SPO-3214858", "R-MMU-400206", "R-DME-400206", "R-HSA-9018519", "R-HSA-9931509", "R-DRE-9018519", "R-MMU-191859", "R-MMU-8936459", "R-MMU-6804760", "R-RNO-400206", "R-SPO-9018519", "R-DME-9018519", "R-SCE-3214858", "R-HSA-381340", "R-DME-9707564", "R-DDI-3214858", "R-RNO-9707564", "R-HSA-9707616", "R-SPO-8876725", "R-HSA-6804760", "R-MMU-3214858", "R-DDI-8876725", "R-HSA-9694631", "R-MMU-8876725", "R-MMU-9018519", "R-SCE-9018519", "R-HSA-9009391", "R-HSA-6804114", "R-CEL-3214858", "R-CEL-9018519", "R-RNO-8876725", "R-HSA-400206", "R-DRE-9707564", "R-DRE-3214858", "R-HSA-2426168", "R-MMU-9707564"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-SCE-8876725:r:Protein methylation", "R-HSA-8876725:r:Protein methylation", "R-XTR-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-191859:r:snRNP Assembly", "R-XTR-3214858:r:RMTs methylate histone arginines", "R-XTR-9018519:r:Estrogen-dependent gene expression", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-XTR-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-DME-3214858:r:RMTs methylate histone arginines", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-BTA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-MMU-191859:r:snRNP Assembly", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-SCE-3214858:r:RMTs methylate histone arginines", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707616:r:Heme signaling", "R-SPO-8876725:r:Protein methylation", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-DDI-8876725:r:Protein methylation", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-MMU-8876725:r:Protein methylation", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-RNO-8876725:r:Protein methylation", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR025800": {"description": "Calmodulin-lysine N-methyltransferase", "go_ids": ["GO:0005737", "GO:0018025"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0018025:calmodulin-lysine N-methyltransferase activity:F"], "name": "CaM-Lys-N-MeTrfase", "pathway_ids": ["R-HSA-8876725", "R-HSA-2514859", "R-RNO-2514859", "R-MMU-2514859", "R-MMU-8876725", "R-RNO-8876725"], "pathways": ["R-HSA-8876725:r:Protein methylation", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-8876725:r:Protein methylation", "R-RNO-8876725:r:Protein methylation"], "type": "Family"}, "IPR025824": {"description": "OB-fold nucleic acid binding domain", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "OB-fold_nuc-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025826": {"description": "Cob(I)alamin adenosyltransferase N-terminal domain", "go_ids": [], "go_terms": [], "name": "Co_AT_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025827": {"description": "Recombinase zinc beta ribbon domain", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_recom_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025828": {"description": "Putative sensor domain", "go_ids": [], "go_terms": [], "name": "Put_sensor_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025829": {"description": "Zinc knuckle CX2CX3GHX4C", "go_ids": [], "go_terms": [], "name": "Zn_knuckle_CX2CX3GHX4C", "pathway_ids": ["R-SPO-983168", "R-SPO-9770562", "R-MMU-9013422", "R-HSA-983168", "R-HSA-9013422", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-983168"], "pathways": ["R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR025830": {"description": "DNA-binding domain, ovate family-like", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "DNA_bnd_dom_ovate", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025832": {"description": "GxGYxYP putative glycoside hydrolase, C-terminal", "go_ids": [], "go_terms": [], "name": "GxGYxYP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025833": {"description": "GDYXXLXY protein", "go_ids": [], "go_terms": [], "name": "GDYXXLXY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025834": {"description": "Topoisomerase I C-terminal domain", "go_ids": [], "go_terms": [], "name": "TopoI_C_dom", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-HSA-4615885", "R-SPO-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Domain"}, "IPR025835": {"description": "Thiopurine S-methyltransferase", "go_ids": ["GO:0008119"], "go_terms": ["GO:0008119:thiopurine S-methyltransferase activity:F"], "name": "Thiopurine_S-MeTrfase", "pathway_ids": ["R-MMU-9748787", "R-BTA-156581", "R-HSA-9748787", "R-HSA-5578995", "R-BTA-9748787", "R-DRE-156581", "R-RNO-9748787", "R-RNO-156581", "R-HSA-156581", "R-DRE-9748787", "R-CFA-156581", "R-CFA-9748787", "R-MMU-156581"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-BTA-156581:r:Methylation", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-5578995:r:Defective TPMT causes TPMT deficiency", "R-BTA-9748787:r:Azathioprine ADME", "R-DRE-156581:r:Methylation", "R-RNO-9748787:r:Azathioprine ADME", "R-RNO-156581:r:Methylation", "R-HSA-156581:r:Methylation", "R-DRE-9748787:r:Azathioprine ADME", "R-CFA-156581:r:Methylation", "R-CFA-9748787:r:Azathioprine ADME", "R-MMU-156581:r:Methylation"], "type": "Family"}, "IPR025836": {"description": "Zinc knuckle CX2CX4HX4C", "go_ids": [], "go_terms": [], "name": "Zn_knuckle_CX2CX4HX4C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025837": {"description": "CFTR regulator domain", "go_ids": [], "go_terms": [], "name": "CFTR_reg_dom", "pathway_ids": ["R-DRE-8856825", "R-MMU-382556", "R-HSA-9925563", "R-HSA-9646399", "R-MMU-8856828", "R-DRE-5689880", "R-DRE-382556", "R-RNO-8856825", "R-DRE-9646399", "R-CFA-9013406", "R-MMU-8856825", "R-HSA-5627083", "R-HSA-8856828", "R-HSA-5689880", "R-HSA-382556", "R-HSA-5678895", "R-RNO-5627083", "R-RNO-382556", "R-MMU-5627083", "R-CFA-382556", "R-RNO-5689880", "R-DRE-9013406", "R-CFA-5689880", "R-MMU-5689880", "R-MMU-9646399", "R-CFA-9646399", "R-HSA-8856825", "R-MMU-9013406", "R-HSA-9613829", "R-RNO-9646399", "R-RNO-8856828", "R-RNO-9013406", "R-HSA-9615710", "R-HSA-9013406", "R-DRE-5627083", "R-CFA-5627083"], "pathways": ["R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-9646399:r:Aggrephagy", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-9646399:r:Aggrephagy", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-RNO-5627083:r:RHO GTPases regulate CFTR trafficking", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-MMU-5627083:r:RHO GTPases regulate CFTR trafficking", "R-CFA-382556:r:ABC-family proteins mediated transport", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-CFA-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-9646399:r:Aggrephagy", "R-CFA-9646399:r:Aggrephagy", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-RNO-9646399:r:Aggrephagy", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DRE-5627083:r:RHO GTPases regulate CFTR trafficking", "R-CFA-5627083:r:RHO GTPases regulate CFTR trafficking"], "type": "Domain"}, "IPR025838": {"description": "Inactive transglutaminase fused to 7 transmembrane helices", "go_ids": [], "go_terms": [], "name": "Transglut_i_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025839": {"description": "RimK-like ATPgrasp N-terminal domain", "go_ids": [], "go_terms": [], "name": "RLAN_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025840": {"description": "7 transmembrane helices usually fused to an inactive transglutaminase", "go_ids": [], "go_terms": [], "name": "7TM_transglut", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025841": {"description": "Circularly permuted ATP-grasp type 2", "go_ids": [], "go_terms": [], "name": "CP_ATPgrasp_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025842": {"description": "Ribosomally synthesized peptide in Bacteroidetes", "go_ids": [], "go_terms": [], "name": "Bacteroid_pep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025843": {"description": "Ribosomally synthesized peptide in Actinomycetes", "go_ids": [], "go_terms": [], "name": "Actino_peptide", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025845": {"description": "Thg1 C-terminal domain", "go_ids": [], "go_terms": [], "name": "Thg1_C_dom", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR025846": {"description": "Trichome birefringence-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TBL_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025847": {"description": "MEDS domain", "go_ids": [], "go_terms": [], "name": "MEDS_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025849": {"description": "MJ0421-like, SPOUT RNA methylase domain", "go_ids": [], "go_terms": [], "name": "MJ0421-like_SPOUT_MTase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025850": {"description": "SUKH-3 immunity protein", "go_ids": [], "go_terms": [], "name": "SUKH-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025851": {"description": "SUKH-4 immunity protein", "go_ids": [], "go_terms": [], "name": "SUKH-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025852": {"description": "Ataxin 2, SM domain", "go_ids": [], "go_terms": [], "name": "SM_dom_ATX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025853": {"description": "Bd3614-like deaminase", "go_ids": [], "go_terms": [], "name": "NH3ase_Bd3614-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025854": {"description": "Bd3614-like deaminase, N-terminal", "go_ids": [], "go_terms": [], "name": "NH3ase_Bd3614-like_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025855": {"description": "Plasmid replication-relaxation", "go_ids": [], "go_terms": [], "name": "Replic_Relax", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025856": {"description": "HeH/LEM domain", "go_ids": [], "go_terms": [], "name": "HeH/LEM_domain", "pathway_ids": ["R-SCE-9668328", "R-SPO-9668328"], "pathways": ["R-SCE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III"], "type": "Domain"}, "IPR025857": {"description": "MacB-like periplasmic core domain", "go_ids": [], "go_terms": [], "name": "MacB_PCD", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638334", "R-HSA-9760173"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR025858": {"description": "Exopolysaccharide production protein YjbE", "go_ids": [], "go_terms": [], "name": "YjbE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025859": {"description": "AurF/CmlI", "go_ids": [], "go_terms": [], "name": "AurF/CmlI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025860": {"description": "Major prion protein N-terminal", "go_ids": [], "go_terms": [], "name": "Prion_N", "pathway_ids": ["R-RNO-9609523", "R-MMU-9609523", "R-HSA-419037", "R-HSA-9609523"], "pathways": ["R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Domain"}, "IPR025861": {"description": "Cobalamin biosynthesis protein CobT VWA domain", "go_ids": [], "go_terms": [], "name": "CobT_VWA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025862": {"description": "L-seryl-tRNA selenium transferase N-terminal domain", "go_ids": [], "go_terms": [], "name": "SelA_trans_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025863": {"description": "Choline sulfatase enzyme C-terminal domain", "go_ids": [], "go_terms": [], "name": "Choline_sulf_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025864": {"description": "Type-F conjugative transfer system protein TraW, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TraW_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025865": {"description": "Cobaltochelatase subunit CobS N-terminal domain", "go_ids": [], "go_terms": [], "name": "CobS_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025866": {"description": "Polymerase A arginine-rich C-terminal domain", "go_ids": [], "go_terms": [], "name": "PolyA_pol_arg_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025867": {"description": "MnmE, helical domain", "go_ids": [], "go_terms": [], "name": "MnmE_helical", "pathway_ids": ["R-HSA-6787450"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR025868": {"description": "Putative zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_dom_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025870": {"description": "Glyoxalase-like domain", "go_ids": [], "go_terms": [], "name": "Glyoxalase-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025871": {"description": "Growth hormone-binding protein", "go_ids": [], "go_terms": [], "name": "GHBP", "pathway_ids": ["R-RNO-1170546", "R-MMU-982772", "R-RNO-982772", "R-MMU-1170546", "R-HSA-1170546", "R-HSA-982772"], "pathways": ["R-RNO-1170546:r:Prolactin receptor signaling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-982772:r:Growth hormone receptor signaling"], "type": "Domain"}, "IPR025872": {"description": "RING finger-like, prokaryotic", "go_ids": [], "go_terms": [], "name": "RING_finger_2_prok", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025873": {"description": "Metal binding domain, predicted", "go_ids": [], "go_terms": [], "name": "Metal-bd_dom_prd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025874": {"description": "Double zinc ribbon", "go_ids": [], "go_terms": [], "name": "DZR", "pathway_ids": ["R-DDI-9013149", "R-DDI-193648"], "pathways": ["R-DDI-9013149:r:RAC1 GTPase cycle", "R-DDI-193648:r:NRAGE signals death through JNK"], "type": "Domain"}, "IPR025875": {"description": "Leucine rich repeat 4", "go_ids": [], "go_terms": [], "name": "Leu-rich_rpt_4", "pathway_ids": ["R-DDI-354192", "R-SPO-6798695", "R-DDI-446388", "R-HSA-9725554", "R-HSA-8951664", "R-HSA-166016", "R-DDI-6803207", "R-DDI-199418", "R-HSA-9824878", "R-DDI-9013149", "R-HSA-936964", "R-DDI-8951664", "R-MMU-8951664", "R-DDI-5675482", "R-DDI-381676", "R-DDI-5213460", "R-DDI-5673000", "R-BTA-2022854", "R-HSA-937041", "R-DDI-9013423", "R-HSA-9833110", "R-HSA-177929", "R-HSA-5686938", "R-HSA-937072", "R-HSA-9918481", "R-DDI-193648", "R-DDI-171007", "R-HSA-166058", "R-DDI-3295583", "R-BTA-168142", "R-DDI-392517", "R-DDI-5673001", "R-HSA-9707616", "R-DDI-5223345", "R-HSA-6807004", "R-DDI-1169092", "R-HSA-166166", "R-HSA-983168", "R-DDI-5675221", "R-HSA-9820960", "R-HSA-8876493", "R-DDI-983168", "R-HSA-2562578", "R-DDI-5674135", "R-HSA-8955332", "R-MMU-983168", "R-HSA-5603041", "R-HSA-1236974", "R-HSA-5602498", "R-HSA-140534", "R-DDI-9013404", "R-MMU-9696264", "R-MMU-9013149", "R-BTA-216083", "R-MMU-9696270", "R-HSA-8875360", "R-BTA-2022857", "R-HSA-975163"], "pathways": ["R-DDI-354192:r:Integrin signaling", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-8951664:r:Neddylation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DDI-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-DDI-5673000:r:RAF activation", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DDI-171007:r:p38MAPK events", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-DDI-3295583:r:TRP channels", "R-BTA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-DDI-392517:r:Rap1 signalling", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-9707616:r:Heme signaling", "R-DDI-5223345:r:Miscellaneous transport and binding events", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DDI-1169092:r:Activation of RAS in B cells", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-216083:r:Integrin cell surface interactions", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-BTA-2022857:r:Keratan sulfate degradation", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Repeat"}, "IPR025876": {"description": "Trafficking protein particle complex subunit 11, C-terminal", "go_ids": [], "go_terms": [], "name": "TRAPPC11_C", "pathway_ids": ["R-HSA-8876198", "R-DRE-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR025877": {"description": "MobA-like NTP transferase", "go_ids": [], "go_terms": [], "name": "MobA-like_NTP_Trfase", "pathway_ids": ["PWY-5514"], "pathways": ["PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II"], "type": "Domain"}, "IPR025878": {"description": "Acetyl-CoA dehydrogenase-like C-terminal domain", "go_ids": [], "go_terms": [], "name": "Acyl-CoA_dh-like_C_dom", "pathway_ids": ["PWY-8182", "PWY-3941"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-3941:t:beta-alanine biosynthesis II"], "type": "Domain"}, "IPR025879": {"description": "Pab87 octamerisation domain", "go_ids": [], "go_terms": [], "name": "Pab87_oct", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025880": {"description": "Glycosyl hydrolase family 80, chitosanase", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_80_chitosanase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025881": {"description": "Toxin Ibs", "go_ids": [], "go_terms": [], "name": "Toxin_Ibs", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025882": {"description": "Toxin Fst", "go_ids": [], "go_terms": [], "name": "Toxin_Fst", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025883": {"description": "Cadherin-like beta-sandwich-like domain", "go_ids": [], "go_terms": [], "name": "Cadherin-like_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025884": {"description": "Methyl-CpG binding protein 2/3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MeCpG-bd_2/3_C_dom", "pathway_ids": ["R-HSA-427389", "R-HSA-9843940", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-MMU-8943724", "R-HSA-6804758", "R-HSA-73728", "R-MMU-73762", "R-HSA-9844594", "R-HSA-9845323", "R-HSA-8943724", "R-MMU-6804758", "R-HSA-427413", "R-MMU-3214815"], "pathways": ["R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-73728:r:RNA Polymerase I Promoter Opening", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones"], "type": "Domain"}, "IPR025885": {"description": "PapC, N-terminal domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "PapC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025886": {"description": "Phloem protein 2-like", "go_ids": [], "go_terms": [], "name": "PP2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025887": {"description": "Glycoside hydrolase family 31, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_31_N_dom", "pathway_ids": ["R-MMU-70221", "R-HSA-6798695", "R-HSA-189085", "R-HSA-532668", "R-HSA-70221", "R-HSA-9683686", "R-HSA-9694548", "R-HSA-5357609", "R-MMU-9768727", "R-BTA-6798695", "R-RNO-70221", "R-MMU-189085", "R-HSA-5659898", "R-MMU-6798695", "R-RNO-189085", "R-HSA-9768727", "R-HSA-901042", "R-SSC-189085", "R-RNO-6798695", "R-BTA-70221"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-5357609:r:Glycogen storage disease type II (GAA)", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-HSA-5659898:r:Intestinal saccharidase deficiencies", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-SSC-189085:r:Digestion of dietary carbohydrate", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-70221:r:Glycogen breakdown (glycogenolysis)"], "type": "Domain"}, "IPR025888": {"description": "Meiosis-specific protein MEI4", "go_ids": ["GO:0042138", "GO:0006310"], "go_terms": ["GO:0042138:meiotic DNA double-strand break formation:P", "GO:0006310:DNA recombination:P"], "name": "MEI4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025889": {"description": "General stress protein 17M-like domain", "go_ids": [], "go_terms": [], "name": "GSP17M-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025890": {"description": "Abhydrolase, bacterial", "go_ids": [], "go_terms": [], "name": "Abhydrolase_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025891": {"description": "Developmental pluripotency-associated protein 2/4, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Dppa2/4_C_dom", "pathway_ids": ["R-HSA-9819196", "R-HSA-2892247"], "pathways": ["R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "type": "Domain"}, "IPR025892": {"description": "Developmental pluripotency-associated protein 2/4, central domain", "go_ids": [], "go_terms": [], "name": "Dppa2/4_central_dom", "pathway_ids": ["R-HSA-9819196", "R-HSA-2892247"], "pathways": ["R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "type": "Domain"}, "IPR025893": {"description": "Tocopherol cyclase", "go_ids": ["GO:0009976"], "go_terms": ["GO:0009976:tocopherol cyclase activity:F"], "name": "Tocopherol_cyclase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025894": {"description": "Polycomb-like MTF2 factor 2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Mtf2_C_dom", "pathway_ids": ["R-HSA-212300", "R-MMU-212300"], "pathways": ["R-HSA-212300:r:PRC2 methylates histones and DNA", "R-MMU-212300:r:PRC2 methylates histones and DNA"], "type": "Domain"}, "IPR025895": {"description": "Lysine-2,3-aminomutase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LAM_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025896": {"description": "Spi protease inhibitor", "go_ids": [], "go_terms": [], "name": "Spi_Prtas-inh", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025897": {"description": "Antitoxin SpoIISB", "go_ids": [], "go_terms": [], "name": "Antitoxin_SpoIISB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025898": {"description": "Tc3 transposase, DNA binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Tc3_transposase_DNA-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025899": {"description": "Phosphatase RapC/F inhibitor", "go_ids": [], "go_terms": [], "name": "PhrC_PhrF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025900": {"description": "Nuclear receptor repeat", "go_ids": [], "go_terms": [], "name": "Nuclear_receptor_repeat", "pathway_ids": ["R-MMU-383280", "R-RNO-383280", "R-HSA-383280"], "pathways": ["R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-HSA-383280:r:Nuclear Receptor transcription pathway"], "type": "Repeat"}, "IPR025901": {"description": "Kinesin-associated microtubule-binding domain", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "Kinesin-assoc_MT-bd_dom", "pathway_ids": ["R-DME-983189", "R-HSA-6811434", "R-HSA-2132295", "R-XTR-6811434", "R-HSA-983189", "R-MMU-2132295", "R-MMU-983189", "R-XTR-983189", "R-MMU-6811434"], "pathways": ["R-DME-983189:r:Kinesins", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-2132295:r:MHC class II antigen presentation", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-983189:r:Kinesins", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983189:r:Kinesins", "R-XTR-983189:r:Kinesins", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR025902": {"description": "LssY-like C-terminal domain", "go_ids": [], "go_terms": [], "name": "LssY-like-C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025903": {"description": "Phostensin/Taperin N-terminal domain", "go_ids": [], "go_terms": [], "name": "Phostensin/Taperin_N_dom", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR025904": {"description": "Tubulin-like", "go_ids": [], "go_terms": [], "name": "Tubulin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025905": {"description": "NVEALA protein", "go_ids": [], "go_terms": [], "name": "NVEALA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025906": {"description": "Putative motility protein", "go_ids": [], "go_terms": [], "name": "YjfB_motility", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025907": {"description": "Phostensin/Taperin PP1-binding domain", "go_ids": ["GO:0019902"], "go_terms": ["GO:0019902:phosphatase binding:F"], "name": "Phostensin/Taperin_PP1-bd_dom", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR025908": {"description": "Sensor N-terminal transmembrane domain", "go_ids": [], "go_terms": [], "name": "Sensor_TM1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025909": {"description": "Phosphoprotein P soyouz module", "go_ids": [], "go_terms": [], "name": "Soyouz_module", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025910": {"description": "Plant viral polyprotein P1, serine peptidase domain", "go_ids": [], "go_terms": [], "name": "P1_Ser_Pept_dom", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR025911": {"description": "ToxN/AbiQ toxin", "go_ids": ["GO:0004521", "GO:0003723"], "go_terms": ["GO:0004521:RNA endonuclease activity:F", "GO:0003723:RNA binding:F"], "name": "ToxN/AbiQ_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025912": {"description": "Regulatory protein YrvL", "go_ids": [], "go_terms": [], "name": "YrvL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025913": {"description": "Cep57 centrosome localisation domain", "go_ids": ["GO:0042802", "GO:0043015"], "go_terms": ["GO:0042802:identical protein binding:F", "GO:0043015:gamma-tubulin binding:F"], "name": "Cep57_CLD", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-HSA-380284", "R-MMU-380270", "R-HSA-380270", "R-RNO-5620912", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-RNO-380259", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR025914": {"description": "Stage V sporulation protein AE", "go_ids": [], "go_terms": [], "name": "SpoVAE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025915": {"description": "Phage protein (N4 Gp49/phage Sf6 gene 66) family", "go_ids": [], "go_terms": [], "name": "Phage_gp49_66", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025916": {"description": "Cold-inducible protein YdjO", "go_ids": [], "go_terms": [], "name": "YdjO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025917": {"description": "Putative membrane protein YuiB", "go_ids": [], "go_terms": [], "name": "YuiB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025918": {"description": "YIEGIA protein", "go_ids": [], "go_terms": [], "name": "YIEGIA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025919": {"description": "Stimulus-sensing domain", "go_ids": [], "go_terms": [], "name": "Stimulus_sens_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025920": {"description": "Bacterial virulence factor lipase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Lipase_bact_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025921": {"description": "HmuY protein", "go_ids": [], "go_terms": [], "name": "HmuY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025922": {"description": "Minor type IV pilin, PilX-like", "go_ids": [], "go_terms": [], "name": "Pilin_PilX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025923": {"description": "YodL-like domain", "go_ids": [], "go_terms": [], "name": "YodL-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025924": {"description": "YHYH domain", "go_ids": [], "go_terms": [], "name": "YHYH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025925": {"description": "PPC89 centrosome localisation domain", "go_ids": [], "go_terms": [], "name": "PPC89_CLD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025926": {"description": "PDZ-like domain", "go_ids": [], "go_terms": [], "name": "PDZ-like_dom", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR025927": {"description": "KANL2-like, probable zinc-finger domain", "go_ids": [], "go_terms": [], "name": "Znf_KANL2-like", "pathway_ids": ["R-MMU-3214847", "R-BTA-9772755", "R-RNO-3214847", "R-RNO-9772755", "R-HSA-9772755", "R-HSA-5696394", "R-BTA-3214847", "R-MMU-5696394", "R-HSA-5689603", "R-MMU-5689603", "R-MMU-9772755", "R-HSA-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-3214847:r:HATs acetylate histones", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-3214847:r:HATs acetylate histones", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR025928": {"description": "Flocculin type 3 repeat", "go_ids": [], "go_terms": [], "name": "Flocculin_t3_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR025929": {"description": "Insulin-induced protein family", "go_ids": [], "go_terms": [], "name": "INSIG_fam", "pathway_ids": ["R-HSA-1655829"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "type": "Family"}, "IPR025930": {"description": "NETI protein", "go_ids": [], "go_terms": [], "name": "NETI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025931": {"description": "TaqI-like C-terminal specificity 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["R-MMU-2500257", "R-DME-9648025", "R-RNO-68877", "R-BTA-9696270", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-9696270", "R-RNO-2500257", "R-RNO-9696270", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-BTA-5663220", "R-MMU-68877", "R-HSA-9648025", "R-RNO-5663220", "R-BTA-2467813", "R-HSA-68877", "R-BTA-2500257", "R-RNO-9648025", "R-MMU-9696270", "R-RNO-2467813", "R-HSA-5663220", "R-BTA-9648025", "R-BTA-141444", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-BTA-9696270:r:RND2 GTPase cycle", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Domain"}, "IPR025935": {"description": "Bacteriophage abortive infection AbiH", "go_ids": [], "go_terms": [], "name": "AbiH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025937": {"description": "PDGLE domain", "go_ids": [], "go_terms": [], "name": "PDGLE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025938": {"description": "RRXRR domain", "go_ids": [], "go_terms": [], "name": "RRXRR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025939": {"description": "Axin interactor dorsalization-associated protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Aida_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025940": {"description": "Toxin SpoIISA, type II toxin-antitoxin system, C-terminal domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "SpoIISA_toxin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025941": {"description": "Vacuolar protein sorting-associated protein 8, central domain", "go_ids": [], "go_terms": [], "name": "Vps8_central_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025942": {"description": "Stage VI sporulation protein F", "go_ids": [], "go_terms": [], "name": "SpoVIF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025945": {"description": "DHHW protein", "go_ids": [], "go_terms": [], "name": "DHHW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025946": {"description": "CABIT domain", "go_ids": [], "go_terms": [], "name": "CABIT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025948": {"description": "HTH-like domain", "go_ids": [], "go_terms": [], "name": "HTH-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025949": {"description": "PapC-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PapC-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025951": {"description": "GXWXG domain", "go_ids": [], "go_terms": [], "name": "GXWXG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025952": {"description": "R3H-associated N-terminal domain", "go_ids": [], "go_terms": [], "name": "R3H-assoc_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025953": {"description": "Putative coat protein YlbD", "go_ids": [], "go_terms": [], "name": "YlbD_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025954": {"description": "DBC1/CARP1, catalytically inactive NUDIX hydrolase domain", "go_ids": [], "go_terms": [], "name": "DBC1/CARP1_inactive_NUDIX", "pathway_ids": ["R-HSA-9770562", "R-HSA-9918481", "R-HSA-72163", "R-HSA-3371453"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR025955": {"description": "Type-IV secretion system protein TraC/Conjugative transfer ATPase", "go_ids": [], "go_terms": [], "name": "TraC/Conjuga_ATPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025956": {"description": "Cytoplasmic dynein 1 intermediate chain 1/2", "go_ids": ["GO:0007018", "GO:0005868"], "go_terms": ["GO:0007018:microtubule-based movement:P", "GO:0005868:cytoplasmic dynein complex:C"], "name": "DYNC1I1/DYNC1I2", "pathway_ids": ["R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-HSA-380284", "R-DDI-9646399", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-RNO-380284", "R-BTA-2500257", "R-DRE-5663220", "R-MMU-5620912", "R-DME-6807878", "R-MMU-141444", "R-MMU-380259", "R-HSA-141444", "R-DRE-380320", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-BTA-6811436", "R-MMU-8854518", "R-BTA-3371497", "R-BTA-9646399", "R-RNO-2467813", "R-BTA-9648025", "R-RNO-380270", "R-MMU-3371497", "R-MMU-5663220", "R-RNO-141444", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-BTA-5663220", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-BTA-6807878", "R-BTA-2467813", "R-RNO-2565942", "R-HSA-68877", "R-MMU-2132295", "R-MMU-9648025", "R-HSA-5620912", "R-BTA-2132295", "R-HSA-6811436", "R-MMU-2500257", "R-RNO-68877", "R-DRE-9646399", "R-HSA-2500257", "R-RNO-2132295", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DRE-2500257", "R-HSA-6807878", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-RNO-9646399", "R-HSA-5663220", "R-RNO-9648025", "R-HSA-380259", "R-BTA-141444"], "pathways": ["R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-380284:r:Loss of 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"R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation 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"Uncharacterized protein y4pG/y4sC, wHTH domain", "go_ids": [], "go_terms": [], "name": "Y4pG_wHTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025960": {"description": "Reverse transcriptase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RVT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025961": {"description": "Heavy-metal resistance protein", "go_ids": [], "go_terms": [], "name": "Metal_resist", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025962": {"description": "SdpI/YhfL-like", "go_ids": [], "go_terms": [], "name": "SdpI/YhfL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025963": {"description": "FlgD Tudor-like domain", "go_ids": [], "go_terms": [], "name": "FLgD_Tudor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025964": {"description": "GGGtGRT protein", "go_ids": [], "go_terms": [], "name": "GGGtGRT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025965": {"description": "FlgD/Vpr, Ig-like domain", "go_ids": [], "go_terms": [], "name": "FlgD/Vpr_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025966": {"description": "Oligopeptide transport permease C-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "OppC_N", "pathway_ids": ["R-HSA-9927020", "R-HSA-1222538"], "pathways": ["R-HSA-9927020:r:Heme assimilation", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Domain"}, "IPR025968": {"description": "YwqJ-like deaminase", "go_ids": [], "go_terms": [], "name": "YwqJ_deaminase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025969": {"description": "Abscisic acid G-protein coupled receptor-like domain", "go_ids": [], "go_terms": [], "name": "ABA_GPCR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025970": {"description": "SusE outer membrane protein", "go_ids": [], "go_terms": [], "name": "SusE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025971": {"description": "LppP/LprE lipoprotein", "go_ids": [], "go_terms": [], "name": "LppP/LprE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025972": {"description": "Beta-galactosidase, domain 3", "go_ids": [], "go_terms": [], "name": "BetaGal_dom3", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR025973": {"description": "Cysteine-rich VLP domain", "go_ids": [], "go_terms": [], "name": "Cys_rich_VLP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025974": {"description": "Mif2/CENP-C cupin domain", "go_ids": [], "go_terms": [], "name": "Mif2/CENP-C_cupin", "pathway_ids": ["R-MMU-2500257", "R-HSA-606279", "R-HSA-2500257", "R-MMU-141444", "R-HSA-2467813", "R-HSA-68877", "R-MMU-2467813", "R-MMU-606279", "R-HSA-141444", "R-HSA-5663220", "R-MMU-68877", "R-MMU-9648025", "R-HSA-9648025", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR025975": {"description": "Polysaccharide lyase", "go_ids": [], "go_terms": [], "name": "Polysacc_lyase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025977": {"description": "Nuclear condensin complex subunit 3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cnd3_C", "pathway_ids": ["R-HSA-2514853", "R-SCE-2514853", "R-SPO-2514853"], "pathways": ["R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes"], "type": "Domain"}, "IPR025979": {"description": "ChrR-like cupin domain", "go_ids": [], "go_terms": [], "name": "ChrR-like_cupin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025980": {"description": "ATP-sulfurylase PUA-like domain", "go_ids": [], "go_terms": [], "name": "ATP-Sase_PUA-like_dom", "pathway_ids": ["PWY-6683", "PWY-5278", "PWY-6932", "PWY-5340", "R-MMU-174362", "R-HSA-174362", "R-HSA-2408550", "R-CEL-174362", "R-HSA-6802952", "R-HSA-3560796"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III", "PWY-5278:t:sulfite oxidation III", "PWY-6932:t:selenate reduction", "PWY-5340:t:sulfate activation for sulfonation", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-3560796:r:Defective PAPSS2 causes SEMD-PA"], "type": "Domain"}, "IPR025981": {"description": "Ribosomal RNA aminoglycoside-resistance methyltransferase", "go_ids": [], "go_terms": [], "name": "rRNA_MeTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025982": {"description": "Superinfection exclusion protein B", "go_ids": [], "go_terms": [], "name": "SieB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025983": {"description": "Cysteine-rich CPCC domain", "go_ids": [], "go_terms": [], "name": "Cys_rich_CPCC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025984": {"description": "dCTP pyrophosphatase 1", "go_ids": ["GO:0009143", "GO:0047429"], "go_terms": ["GO:0009143:nucleoside triphosphate catabolic process:P", "GO:0047429:nucleoside triphosphate diphosphatase activity:F"], "name": "DCTPP", "pathway_ids": ["R-HSA-499943"], "pathways": ["R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR025985": {"description": "YnbE", "go_ids": [], "go_terms": [], "name": "YnbE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025986": {"description": "RNA-polymerase II-associated protein 3-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RPAP3-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025987": {"description": "GW domain", "go_ids": [], "go_terms": [], "name": "GW_dom", "pathway_ids": ["PWY-7883", "R-HSA-8875360"], "pathways": ["PWY-7883:t:peptidoglycan recycling II", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell"], "type": "Domain"}, "IPR025988": {"description": "YWFCY domain", "go_ids": [], "go_terms": [], "name": "YWFCY_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025989": {"description": "Virulence factor domain", "go_ids": [], "go_terms": [], "name": "Virulence_F_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025990": {"description": "Bacterial zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Zinc_ribbon_bacterial", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR025991": {"description": "Chemoreceptor zinc-binding domain", "go_ids": [], "go_terms": [], "name": "Chemoreceptor_zinc-bind_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025992": {"description": "Haem-binding domain", "go_ids": [], "go_terms": [], "name": "Haem-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR025993": {"description": "Ceramide glucosyltransferase", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "Ceramide_glucosylTrfase", "pathway_ids": ["PWY-5129", "PWY-7839", "PWY-7836", "PWY-7841", "PWY-7838", "R-XTR-9840309", "R-HSA-9840309", "R-CEL-9840309", "R-RNO-9840309", "R-MMU-9840309"], "pathways": ["PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-7839:t:lacto-series glycosphingolipids biosynthesis", "PWY-7836:t:ganglio-series glycosphingolipids biosynthesis", "PWY-7841:t:neolacto-series glycosphingolipids biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "R-XTR-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-CEL-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis"], "type": "Family"}, "IPR025994": {"description": "BRCA1, serine-rich domain", "go_ids": [], "go_terms": [], "name": "BRCA1_serine_dom", "pathway_ids": ["PWY-7511", "R-HSA-5689901", "R-HSA-9825895", "R-HSA-5685942", "R-HSA-3108214", "R-HSA-5693616", "R-HSA-8951664", "R-HSA-9704646", "R-RNO-5693565", "R-MMU-5689901", "R-MMU-6804756", "R-HSA-5693565", "R-RNO-3108214", "R-RNO-5689901", "R-HSA-1221632", "R-HSA-6796648", "R-HSA-8953750", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-5693565", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-5685938", "R-HSA-912446", "R-RNO-6804756", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-HSA-9663199", "R-HSA-9701192", "R-MMU-5693607", "R-RNO-5693579", "R-HSA-69473", "R-RNO-5693607", "R-HSA-9755511", "R-HSA-9709603", "R-MMU-5685942", "R-RNO-5693571", "R-RNO-69473", "R-RNO-5685942", "R-HSA-5693571", "R-HSA-6804756", "R-HSA-9704331", "R-RNO-5693568", "R-RNO-5693616", "R-HSA-5693554", "R-MMU-3108214", "R-HSA-5693579", "R-MMU-5693571", "R-HSA-9699150"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-HSA-5685942:r:HDR 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"R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9663199:r:Defective DNA double strand break response due to BRCA1 loss of function", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9699150:r:Defective DNA double strand break response due to BARD1 loss of function"], "type": "Domain"}, "IPR025995": {"description": "RNA binding activity-knot of a chromodomain", "go_ids": [], "go_terms": [], "name": "Tudor-knot", "pathway_ids": ["R-HSA-5693616", "R-HSA-427413", "R-MMU-3214815", "R-RNO-5693565", "R-MMU-6804756", "R-HSA-5693565", "R-MMU-5693616", "R-RNO-9018519", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-9772755", "R-MMU-5693568", "R-HSA-9018519", "R-DME-5693607", "R-DME-9772755", "R-RNO-5693579", "R-MMU-2559586", "R-HSA-69473", "R-DME-9018519", "R-RNO-5693607", "R-HSA-3214815", "R-RNO-5693571", "R-RNO-69473", "R-MMU-9018519", "R-HSA-6804756", "R-HSA-9704331", "R-RNO-5693568", "R-DME-2559586", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-MMU-5693571", "R-HSA-2559586", "R-HSA-5685942", "R-HSA-9772755", "R-HSA-9704646", "R-DME-5693565", "R-CEL-201722", "R-RNO-5693548", "R-SCE-6804758", "R-MMU-5693565", "R-RNO-5685938", "R-RNO-6804756", "R-MMU-9772755", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-MMU-3214847", "R-RNO-2559586", "R-MMU-5693548", "R-HSA-9679191", "R-MMU-5685942", "R-HSA-9709603", "R-DME-201722", "R-RNO-5685942", "R-HSA-201722", "R-HSA-5693571", "R-RNO-3214847", "R-DME-3214847", "R-SPO-6804758", "R-HSA-9733709", "R-CEL-9018519", "R-HSA-3214847", "R-DME-5693548", "R-HSA-5693579"], "pathways": ["R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-5693607:r:Processing of DNA double-strand break ends", "R-DME-9772755:r:Formation of 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"R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5685938:r:HDR 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"R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-RNO-176407", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-RNO-174154", "R-DDI-176409", "R-DDI-2559582", "R-DDI-2467813", "R-SPO-983168", "R-DDI-176412", "R-SCE-983168", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-RNO-141430", "R-MMU-176408", "R-MMU-176409", "R-DDI-174084", "R-MMU-68867", "R-RNO-176412", "R-SPO-2559582", "R-HSA-176409", "R-HSA-9687136", "R-RNO-174048", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-SPO-179409", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-RNO-179409", "R-RNO-174184", "R-DDI-983168", "R-MMU-174184", "R-RNO-68867", "R-DDI-174184", "R-MMU-141430", "R-RNO-176408", "R-DDI-141430", "R-HSA-69017", "R-RNO-174084", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-RNO-2467813", "R-RNO-983168", "R-DDI-174178", "R-RNO-69017", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-HSA-8853884:r:Transcriptional 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"R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-141430:r:Inactivation of APC/C 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"pathways": [], "type": "Domain"}, "IPR026002": {"description": "L-2-amino-thiazoline-4-carboxylic acid hydrolase-like", "go_ids": [], "go_terms": [], "name": "ATC_hydrolase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026003": {"description": "HEAT repeat associated with sister chromatid cohesion protein", "go_ids": [], "go_terms": [], "name": "Cohesin_HEAT", "pathway_ids": ["R-HSA-2470946", "R-CEL-2470946", "R-SPO-2470946", "R-MMU-2470946", "R-DME-2470946"], "pathways": ["R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-DME-2470946:r:Cohesin Loading onto Chromatin"], "type": "Repeat"}, "IPR026004": {"description": "Septum formation-related domain", "go_ids": [], "go_terms": [], "name": "Septum_form", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026010": {"description": "Nucleoporin NSP1/NUP62", "go_ids": ["GO:0017056", "GO:0005643"], "go_terms": ["GO:0017056:structural constituent of nuclear pore:F", "GO:0005643:nuclear pore:C"], "name": "NSP1/NUP62", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-SPO-159227", "R-MMU-3232142", "R-SPO-159231", "R-RNO-3301854", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230", "R-MMU-4085377", "R-MMU-4551638", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-HSA-4570464", "R-DME-4615885", "R-RNO-159236", "R-SPO-4085377", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-HSA-168276", "R-SPO-159236", "R-HSA-168271", "R-HSA-6784531", "R-SPO-4551638", "R-MMU-3301854", "R-DME-4551638", "R-HSA-4085377", "R-HSA-168325", "R-DME-159227", "R-MMU-170822", "R-RNO-159227", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-RNO-4551638", "R-HSA-3301854", "R-HSA-3232142", "R-MMU-159227", "R-RNO-4085377", "R-HSA-9615933", "R-SPO-4570464", "R-RNO-170822", "R-DME-159230", "R-DME-3301854", "R-RNO-4570464", "R-RNO-159231", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-191859:r:snRNP Assembly", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159231:r:Transport 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SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-191859:r:snRNP Assembly", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4551638:r:SUMOylation 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"R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Family"}, "IPR026015": {"description": "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ATP_synth_OSCP/delta_N_sf", "pathway_ids": ["R-DDI-9837999", "R-MMU-9837999", "R-SSC-8949613", "R-DME-9837999", "R-MMU-163210", "R-DME-163210", "R-RNO-9837999", "R-DME-8949613", "R-HSA-8949613", "R-HSA-163210", "R-BTA-8949613", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-SSC-9837999", "R-BTA-163210", "R-HSA-9837999", "R-RNO-163210", "R-RNO-8949613", "R-MMU-8949613", "R-SSC-163210"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SSC-8949613:r:Cristae formation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic 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(fungi)", "PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Domain"}, "IPR026019": {"description": "Ribulose-phosphate 3-epimerase", "go_ids": ["GO:0006098", "GO:0004750"], "go_terms": ["GO:0006098:pentose-phosphate shunt:P", "GO:0004750:D-ribulose-phosphate 3-epimerase activity:F"], "name": "Ribul_P_3_epim", "pathway_ids": ["PWY-1861", "PWY-8178", "PWY-5723", "R-MMU-71336", "R-HSA-71336", "R-SPO-71336", "R-SCE-71336"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-5723:t:Rubisco shunt", "R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-SCE-71336:r:Pentose phosphate pathway"], "type": "Family"}, "IPR026021": {"description": "Putative NAD(P)H nitroreductase YdjA-like", "go_ids": [], "go_terms": [], "name": "YdjA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026022": {"description": "PhoU domain", "go_ids": [], "go_terms": [], "name": "PhoU_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026024": {"description": "Chemotaxis protein methyltransferase CheR", "go_ids": [], "go_terms": [], "name": "Chemotaxis_MeTrfase_CheR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026025": {"description": "Fatty acid synthase alpha subunit, yeast", "go_ids": ["GO:0005835", "GO:0004316", "GO:0004315", "GO:0008897", "GO:0042759", "GO:0004312"], "go_terms": ["GO:0005835:fatty acid synthase complex:C", "GO:0004316:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity:F", "GO:0004315:3-oxoacyl-[acyl-carrier-protein] synthase activity:F", "GO:0008897:holo-[acyl-carrier-protein] synthase activity:F", "GO:0042759:long-chain fatty acid biosynthetic process:P", "GO:0004312:fatty acid synthase activity:F"], "name": "FAS_alpha_yeast", "pathway_ids": ["PWY-8174", "PWY-8427", "PWY-8280", "PWY-6519", "PWY-8203", "PWY-7663", "PWY-5367", "PWY-5989", "PWY-5966", "PWY-5971", "PWY-8173", "PWY-6113", "PWY-7664", "PWY-8175", "PWY-7858", "PWYG-321", "PWY-7388", "PWY-5994", "PWY-5973", "PWY-8279", "PWY-6282"], "pathways": ["PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWY-5367:t:petroselinate biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "PWY-6113:t:superpathway of mycolate biosynthesis", "PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWYG-321:t:mycolate biosynthesis", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8279:t:palmitate biosynthesis III", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"], "type": "Family"}, "IPR026026": {"description": "Histidine triad hydrolase, Hint-type", "go_ids": [], "go_terms": [], "name": "HIT_Hint", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026027": {"description": "Phosphatidylcholine synthase Pcs", "go_ids": [], "go_terms": [], "name": "PcS", "pathway_ids": ["PWY-6826"], "pathways": ["PWY-6826:t:phosphatidylcholine biosynthesis VI"], "type": "Family"}, "IPR026028": {"description": "ATPase, V0 complex, subunit 116kDa, eukaryotic", "go_ids": ["GO:0046961", "GO:0000220"], "go_terms": ["GO:0046961:proton-transporting ATPase activity, rotational mechanism:F", "GO:0000220:vacuolar proton-transporting 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"R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-XTR-983712:r:Ion channel transport"], "type": "Family"}, "IPR026029": {"description": "Muconolactone isomerase domain", "go_ids": [], "go_terms": [], "name": "MLI_dom", "pathway_ids": ["PWY-6185"], "pathways": ["PWY-6185:t:4-methylcatechol degradation (ortho cleavage)"], "type": "Domain"}, "IPR026030": {"description": "Purine-cytosine permease Fcy2/21/22", "go_ids": ["GO:0022857", "GO:0055085", "GO:0016020"], "go_terms": ["GO:0022857:transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P", "GO:0016020:membrane:C"], "name": "Pur-cyt_permease_Fcy2/21/22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026031": {"description": "Cytochrome c-type biogenesis protein CcmB, bacteria", "go_ids": [], "go_terms": [], "name": "Cyt_c_CcmB_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026032": {"description": "Probable 3-phenylpropionic acid transporter-like", "go_ids": [], "go_terms": [], "name": "HcaT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026033": {"description": "Azaguanine-like transporters, bacteria and archaea type", "go_ids": ["GO:0015205"], "go_terms": ["GO:0015205:nucleobase transmembrane transporter activity:F"], "name": "Azg-like_bact_archaea", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026034": {"description": "Cell shape-determining protein MreD, proteobacterial type", "go_ids": [], "go_terms": [], "name": "MreD_proteobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026036": {"description": "PucC protein", "go_ids": [], "go_terms": [], "name": "PucC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026037": {"description": "Phosphatidylglycerophosphatase A", "go_ids": [], "go_terms": [], "name": "PgpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026038": {"description": "Putative 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"Family"}, "IPR026044": {"description": "Membrane-bound lytic murein transglycosylase A", "go_ids": [], "go_terms": [], "name": "MltA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026045": {"description": "Ferric binding protein", "go_ids": [], "go_terms": [], "name": "Ferric-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026046": {"description": "UbiA prenyltransferase domain containing protein 1", "go_ids": ["GO:0004659"], "go_terms": ["GO:0004659:prenyltransferase activity:F"], "name": "UBIAD1", "pathway_ids": ["R-MMU-6806664", "R-DDI-6806664", "R-DRE-6806664", "R-HSA-6806664", "R-XTR-6806664", "R-DME-6806664", "R-RNO-6806664"], "pathways": ["R-MMU-6806664:r:Metabolism of vitamin K", "R-DDI-6806664:r:Metabolism of vitamin K", "R-DRE-6806664:r:Metabolism of vitamin K", "R-HSA-6806664:r:Metabolism of vitamin K", "R-XTR-6806664:r:Metabolism of vitamin K", "R-DME-6806664:r:Metabolism of vitamin K", "R-RNO-6806664:r:Metabolism of vitamin K"], "type": 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{"description": "Trichome birefringence-like, C-terminal domain", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "TBL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026058": {"description": "LIPIN family", "go_ids": [], "go_terms": [], "name": "LIPIN", "pathway_ids": ["PWY-7782", "PWY-8053", "PWY-8052", "PWY-8051", "PWY-8055", "PWY-6453", "R-HSA-1483191", "R-SPO-75109", "R-HSA-4419969", "R-SCE-75109", "R-HSA-1483213", "R-SCE-1483213", "R-MMU-75109", "R-HSA-75109", "R-MMU-1483191", "R-SPO-1483213", "R-SPO-4419969", "R-SCE-1483191", "R-MMU-4419969", "R-SCE-4419969", "R-MMU-1483213", "R-HSA-9841922", "R-SPO-1483191"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-8053:t:anandamide biosynthesis II", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "R-HSA-1483191:r:Synthesis of PC", 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"type": "Family"}, "IPR026069": {"description": "Fuzzy protein", "go_ids": [], "go_terms": [], "name": "Fuzzy", "pathway_ids": ["R-XTR-5610787", "R-HSA-5610787", "R-DME-5610787", "R-RNO-5610787", "R-DME-450728", "R-MMU-5610787"], "pathways": ["R-XTR-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-5610787:r:Hedgehog 'off' state", "R-RNO-5610787:r:Hedgehog 'off' state", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-5610787:r:Hedgehog 'off' state"], "type": "Family"}, "IPR026071": {"description": "Glycosyl hydrolase family 99", "go_ids": ["GO:0016798"], "go_terms": ["GO:0016798:hydrolase activity, acting on glycosyl bonds:F"], "name": "Glyco_Hydrolase_99", "pathway_ids": ["PWY-7919", "R-MMU-964739", "R-RNO-964739", "R-HSA-964739"], "pathways": ["PWY-7919:t:protein N-glycosylation processing phase (plants and animals)", "R-MMU-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-RNO-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-HSA-964739:r:N-glycan trimming and elongation in the cis-Golgi"], "type": "Family"}, "IPR026072": {"description": "Lck-interacting transmembrane adapter 1", "go_ids": ["GO:0050853", "GO:0050852"], "go_terms": ["GO:0050853:B cell receptor signaling pathway:P", "GO:0050852:T cell receptor signaling pathway:P"], "name": "Lime1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026073": {"description": "Gametogenetin-binding protein 2", "go_ids": [], "go_terms": [], "name": "GGNBP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026074": {"description": "Microtubule associated protein 1", "go_ids": ["GO:0008017", "GO:0005874", "GO:0000226"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0005874:microtubule:C", "GO:0000226:microtubule cytoskeleton organization:P"], "name": "MAP1", "pathway_ids": ["R-HSA-9833110"], "pathways": ["R-HSA-9833110:r:RSV-host interactions"], "type": "Family"}, "IPR026076": {"description": "Late cornified envelope-like proline-rich protein 1", "go_ids": [], "go_terms": [], "name": "Lelp1", "pathway_ids": ["R-HSA-6809371"], "pathways": ["R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Family"}, "IPR026077": {"description": "Protamine-P3", "go_ids": [], "go_terms": [], "name": "PRMP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026079": {"description": "Cerebellar degeneration-related protein 2", "go_ids": [], "go_terms": [], "name": "CDR2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026081": {"description": "Disrupted in schizophrenia 1", "go_ids": [], "go_terms": [], "name": "DISC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026082": {"description": "ABC transporter A", "go_ids": ["GO:0140359", "GO:0055085", "GO:0016020"], "go_terms": ["GO:0140359:ABC-type transporter activity:F", "GO:0055085:transmembrane transport:P", "GO:0016020:membrane:C"], "name": "ABCA", "pathway_ids": ["R-HSA-1989781", "R-HSA-6798695", "R-DDI-382556", "R-BTA-382556", "R-HSA-9918454", "R-CEL-6798695", "R-MMU-1369062", "R-HSA-1369062", "R-HSA-9615017", "R-HSA-5683678", "R-CEL-1369062", "R-HSA-9029569", "R-MMU-9029569", "R-MMU-5683826", "R-MMU-382556", "R-DDI-6798695", "R-DDI-1369062", "R-HSA-8963896", "R-DDI-5683826", "R-HSA-5682294", "R-HSA-382556", "R-MMU-2453902", "R-RNO-5683826", "R-DDI-8963896", "R-HSA-5682113", "R-MMU-8963896", "R-HSA-5683826", "R-HSA-5688399", "R-RNO-1369062", "R-MMU-6798695", "R-BTA-2453902", "R-DDI-2453902", "R-HSA-2453902"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-HSA-9918454:r:Defective visual phototransduction due to ABCA4 loss of function", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-5683678:r:Defective ABCA3 causes SMDP3", "R-CEL-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-8963896:r:HDL assembly", "R-DDI-5683826:r:Surfactant metabolism", "R-HSA-5682294:r:Defective ABCA12 causes ARCI4B", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-5683826:r:Surfactant metabolism", "R-DDI-8963896:r:HDL assembly", "R-HSA-5682113:r:Defective ABCA1 causes TGD", "R-MMU-8963896:r:HDL assembly", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-5688399:r:Defective ABCA3 causes SMDP3", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DDI-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Family"}, "IPR026085": {"description": "Activating transcription factor 7-interacting protein", "go_ids": [], "go_terms": [], "name": "ATF7-int", "pathway_ids": ["R-MMU-9843940", "R-MMU-3214841", "R-DRE-9843940", "R-DRE-3214841", "R-HSA-3214841", "R-GGA-3214841", "R-HSA-9843970", "R-DRE-9843970", "R-HSA-9843940", "R-GGA-9843970", "R-GGA-9843940"], "pathways": ["R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-GGA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-GGA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-GGA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins"], "type": "Family"}, "IPR026086": {"description": "Proline-rich protein", "go_ids": [], "go_terms": [], "name": "Pro-rich", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026087": {"description": "Corneodesmosin", "go_ids": ["GO:0043589"], "go_terms": ["GO:0043589:skin morphogenesis:P"], "name": "Corneodesmosin", "pathway_ids": ["R-MMU-6809371", "R-HSA-6809371"], "pathways": ["R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Family"}, "IPR026088": {"description": "Niban-like", "go_ids": [], "go_terms": [], "name": "Niban-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026091": {"description": "BLOC-3 complex member HPS4", "go_ids": [], "go_terms": [], "name": "HPS4", "pathway_ids": ["R-HSA-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR026092": {"description": "Retinoic acid-induced protein 2/sine oculis-binding protein homologue", "go_ids": [], "go_terms": [], "name": "RAI2/SOBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026093": {"description": "Protein MGARP", "go_ids": ["GO:0005739", "GO:0008089"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0008089:anterograde axonal transport:P"], "name": "MGARP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026094": {"description": "G protein pathway suppressor 2", "go_ids": [], "go_terms": [], "name": "GPS2", "pathway_ids": ["R-HSA-1989781", "R-HSA-9022692", "R-HSA-9022537", "R-MMU-9841922", "R-HSA-3214815", "R-HSA-9029569", "R-HSA-9609690", "R-HSA-9841922", "R-MMU-9029569"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9022537:r:Loss of MECP2 binding ability to the NCoR/SMRT complex", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "type": "Family"}, "IPR026095": {"description": "Myb/SANT-like DNA-binding domain-containing protein", "go_ids": [], "go_terms": [], "name": "Myb/SANT-like_DNA-bd_dom_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026096": {"description": "Receptor-transporting protein", "go_ids": [], "go_terms": [], "name": "R-trans_p", "pathway_ids": ["R-HSA-9752946"], "pathways": ["R-HSA-9752946:r:Expression and translocation of olfactory receptors"], "type": "Family"}, "IPR026097": {"description": "S100P-binding protein", "go_ids": ["GO:0048306"], "go_terms": ["GO:0048306:calcium-dependent protein binding:F"], "name": "S100PBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026099": {"description": "Outer dense fiber protein 2/Protein BCAP", "go_ids": [], "go_terms": [], "name": "ODF2/BCAP", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-MMU-380270", "R-HSA-380284", "R-HSA-380270", "R-RNO-5620912", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-RNO-380259", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Family"}, "IPR026100": {"description": "Transmembrane protein 223", "go_ids": [], "go_terms": [], "name": "Tmem223", "pathway_ids": ["R-HSA-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR026104": {"description": "Zinc finger C2HC domain-containing protein 1C", "go_ids": [], "go_terms": [], "name": "ZNF_C2HC_dom_1C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026106": {"description": "Microtubule-associated protein 9", "go_ids": ["GO:0051225", "GO:0000281"], "go_terms": ["GO:0051225:spindle assembly:P", "GO:0000281:mitotic cytokinesis:P"], "name": "MAP9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026109": {"description": "G kinase-anchoring protein 1", "go_ids": ["GO:0005794", "GO:0007165"], "go_terms": ["GO:0005794:Golgi apparatus:C", "GO:0007165:signal transduction:P"], "name": "GKAP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026110": {"description": "Lymphocyte antigen 6 complex locus protein G5c", "go_ids": [], "go_terms": [], "name": "LY6G5C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026111": {"description": "Actin-binding Rho-activating protein", "go_ids": ["GO:0035025", "GO:0003779"], "go_terms": ["GO:0035025:positive regulation of Rho protein signal transduction:P", "GO:0003779:actin binding:F"], "name": "Abra", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026112": {"description": "Amnionless", "go_ids": [], "go_terms": [], "name": "AMN", "pathway_ids": ["R-HSA-3359462", "R-HSA-8964011", "R-HSA-9758881", "R-DME-9758881", "R-HSA-3359463"], "pathways": ["R-HSA-3359462:r:Defective AMN causes MGA1", "R-HSA-8964011:r:HDL clearance", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DME-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-3359463:r:Defective CUBN causes MGA1"], "type": "Family"}, "IPR026113": {"description": "tRNA N(3)-methylcytidine methyltransferase METTL2/6/8-like", "go_ids": [], "go_terms": [], "name": "METTL2/6/8-like", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR026114": {"description": "Apolipoprotein F", "go_ids": [], "go_terms": [], "name": "APOF", "pathway_ids": ["R-HSA-8964041"], "pathways": ["R-HSA-8964041:r:LDL remodeling"], "type": "Family"}, "IPR026115": {"description": "Novel Amplified in Breast Cancer-1", "go_ids": [], "go_terms": [], "name": "NABC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026116": {"description": "Glycosyltransferase family 18, catalytic domain", "go_ids": ["GO:0030144"], "go_terms": ["GO:0030144:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity:F"], "name": "GT18_cat", "pathway_ids": ["PWY-7426", "R-HSA-975577", "R-RNO-975577", "R-CEL-975577", "R-CEL-8932504", "R-MMU-975577", "R-MMU-8932504", "R-HSA-9694548", "R-HSA-8932504"], "pathways": ["PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "R-HSA-975577:r:N-Glycan antennae elongation", "R-RNO-975577:r:N-Glycan antennae elongation", "R-CEL-975577:r:N-Glycan antennae elongation", "R-CEL-8932504:r:DAG1 core M2 glycosylations", "R-MMU-975577:r:N-Glycan antennae elongation", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-8932504:r:DAG1 core M2 glycosylations"], "type": "Domain"}, "IPR026117": {"description": "Prostate apoptosis response 4", "go_ids": ["GO:0006915"], "go_terms": ["GO:0006915:apoptotic process:P"], "name": "Par-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026118": {"description": "Calcium-binding and spermatid-specific protein 1", "go_ids": ["GO:0005509", "GO:0007283"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0007283:spermatogenesis:P"], "name": "Ca-bd_spermatid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026120": {"description": "Transmembrane protein 11", "go_ids": ["GO:0005743", "GO:0007005"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C", "GO:0007005:mitochondrion organization:P"], "name": "TMEM11", "pathway_ids": ["R-HSA-8949613"], "pathways": ["R-HSA-8949613:r:Cristae formation"], "type": "Family"}, "IPR026123": {"description": "STIL", "go_ids": [], "go_terms": [], "name": "STIL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026124": {"description": "Sperm-associated antigen 8", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "Sperm-assoc_Ag8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026126": {"description": "BRISC and BRCA1-A complex member 1", "go_ids": ["GO:0070531", "GO:0070552", "GO:0045739"], "go_terms": ["GO:0070531:BRCA1-A complex:C", "GO:0070552:BRISC complex:C", "GO:0045739:positive regulation of DNA repair:P"], "name": "BABAM1", "pathway_ids": ["R-HSA-5689901", "R-DRE-5693607", "R-BTA-69473", "R-HSA-69473", "R-RNO-5693565", "R-MMU-5689901", "R-RNO-5693607", "R-BTA-5693565", "R-HSA-5693565", "R-RNO-5689901", "R-RNO-5693571", "R-RNO-69473", "R-MMU-5693565", "R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-BTA-5693607", "R-BTA-5693571", "R-DRE-5693565", "R-MMU-5693571", "R-BTA-5689901", "R-MMU-5693607", "R-DRE-5689901"], "pathways": ["R-HSA-5689901:r:Metalloprotease DUBs", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5689901:r:Metalloprotease DUBs", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-5689901:r:Metalloprotease DUBs", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5689901:r:Metalloprotease DUBs"], "type": "Family"}, "IPR026128": {"description": "Neurosecretory protein VGF", "go_ids": ["GO:0005184"], "go_terms": ["GO:0005184:neuropeptide hormone activity:F"], "name": "VGF", "pathway_ids": ["R-RNO-381426", "R-MMU-381426", "R-HSA-8957275", "R-HSA-9031628", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9031628:r:NGF-stimulated transcription", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR026130": {"description": "Protein phosphatase 1 regulatory subunit 26", "go_ids": ["GO:0010923", "GO:0004864"], "go_terms": ["GO:0010923:negative regulation of phosphatase activity:P", "GO:0004864:protein phosphatase inhibitor activity:F"], "name": "PPP1R26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026131": {"description": "Mastermind-like domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "MAMLD1", "pathway_ids": ["R-HSA-9013695", "R-HSA-9013508", "R-HSA-8941856", "R-MMU-350054", "R-HSA-210744", "R-MMU-2122947", "R-MMU-8941856", "R-HSA-2894862", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-2122947", "R-HSA-350054", "R-HSA-1912408"], "pathways": ["R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation"], "type": "Family"}, "IPR026133": {"description": "Tastin", "go_ids": [], "go_terms": [], "name": "Tastin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026134": {"description": "MyoD family inhibitor/MyoD family inhibitor domain-containing protein", "go_ids": [], "go_terms": [], "name": "MDFI/MDFIC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026135": {"description": "Uncharacterised protein C6orf15", "go_ids": [], "go_terms": [], "name": "C6orf15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026136": {"description": "RIPOR family member 3", "go_ids": [], "go_terms": [], "name": "RIPOR3", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Family"}, "IPR026137": {"description": "Leucine-rich repeat-containing 41", "go_ids": [], "go_terms": [], "name": "Leu_rpt_41", "pathway_ids": ["R-MMU-8951664", "R-HSA-9706019", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-RNO-9706019", "R-MMU-9706019", "R-HSA-983168", "R-RNO-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR026138": {"description": "Ceroid-lipofuscinosis neuronal protein 5", "go_ids": ["GO:0005764"], "go_terms": ["GO:0005764:lysosome:C"], "name": "CLN5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026139": {"description": "GOLM1/CASC4 family", "go_ids": [], "go_terms": [], "name": "GOLM1/CASC4", "pathway_ids": ["R-MMU-381426", "R-HSA-8957275", "R-HSA-381426", "R-MMU-8957275"], "pathways": ["R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8957275:r:Post-translational protein phosphorylation"], "type": "Family"}, "IPR026140": {"description": "Small ribosomal subunit protein mS26", "go_ids": ["GO:0005763"], "go_terms": ["GO:0005763:mitochondrial small ribosomal subunit:C"], "name": "Ribosomal_mS26", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-RNO-9937383", "R-BTA-9937383", "R-MMU-5389840", "R-DME-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR026142": {"description": "Protein phosphatase 1 regulatory subunit 36", "go_ids": ["GO:0019902", "GO:0010923"], "go_terms": ["GO:0019902:phosphatase binding:F", "GO:0010923:negative regulation of phosphatase activity:P"], "name": "Pro_pase_1_reg_su_36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026144": {"description": "Neuritin family", "go_ids": ["GO:0007399"], "go_terms": ["GO:0007399:nervous system development:P"], "name": "Neuritin_fam", "pathway_ids": ["R-MMU-163125", "R-BTA-163125", "R-RNO-163125", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR026145": {"description": "Interleukin-33", "go_ids": ["GO:0005125"], "go_terms": ["GO:0005125:cytokine activity:F"], "name": "IL-33", "pathway_ids": ["R-MMU-5689880", "R-HSA-9014843", "R-HSA-6811558", "R-RNO-6811558", "R-CFA-6811558", "R-HSA-5689880", "R-MMU-6811558", "R-RNO-1257604", "R-RNO-9014843", "R-MMU-9014843", "R-HSA-1257604", "R-MMU-1257604", "R-RNO-5689880", "R-CFA-1257604", "R-CFA-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9014843:r:Interleukin-33 signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-9014843:r:Interleukin-33 signaling", "R-MMU-9014843:r:Interleukin-33 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-CFA-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR026146": {"description": "Small ribosomal 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"R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR026147": {"description": "Rab3GAP catalytic subunit, conserved domain", "go_ids": [], "go_terms": [], "name": "Rab3GAP1_conserved", "pathway_ids": ["R-RNO-6811436", "R-MMU-8876198", "R-CEL-8876198", "R-DME-6811436", "R-DME-8876198", "R-CEL-6811436", "R-RNO-8876198", "R-HSA-8876198", "R-HSA-6811436", "R-MMU-6811436"], "pathways": ["R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR026151": {"description": "Maspardin", "go_ids": [], "go_terms": [], "name": "Maspardin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026152": {"description": "Specifically androgen-regulated gene protein", "go_ids": [], "go_terms": [], "name": "SARG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026153": {"description": "Treslin", "go_ids": ["GO:0005634", "GO:0006260", "GO:0033314", "GO:0010212"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006260:DNA replication:P", "GO:0033314:mitotic DNA replication checkpoint signaling:P", "GO:0010212:response to ionizing radiation:P"], "name": "Treslin", "pathway_ids": ["R-HSA-69273", "R-MMU-69273", "R-DRE-69273"], "pathways": ["R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DRE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition"], "type": "Family"}, "IPR026155": {"description": "Apelin", "go_ids": ["GO:0007165", "GO:0005179", "GO:0031704"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0005179:hormone activity:F", "GO:0031704:apelin receptor binding:F"], "name": "Apelin", "pathway_ids": ["R-DRE-418594", "R-DRE-375276", "R-HSA-418594", "R-MMU-375276", "R-RNO-375276", "R-HSA-375276", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-375276:r:Peptide ligand-binding receptors", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR026157": {"description": "Leucine zipper transcription factor-like protein 1", "go_ids": [], "go_terms": [], "name": "LZTFL1", "pathway_ids": ["R-MMU-5620922", "R-HSA-5620922", "R-RNO-5620922", "R-BTA-5620922"], "pathways": ["R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-BTA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Family"}, "IPR026158": {"description": "Apolipoprotein B receptor", "go_ids": ["GO:0030228", "GO:0006869"], "go_terms": ["GO:0030228:lipoprotein particle receptor activity:F", "GO:0006869:lipid transport:P"], "name": "ApolipoprotB_rcpt", "pathway_ids": ["R-HSA-8964046", "R-MMU-8964046"], "pathways": ["R-HSA-8964046:r:VLDL clearance", "R-MMU-8964046:r:VLDL clearance"], "type": "Family"}, "IPR026159": {"description": "Cerebral cavernous malformations 2", "go_ids": [], "go_terms": [], "name": "Malcavernin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026160": {"description": "Resistance to inhibitors of cholinesterase protein 3", "go_ids": [], "go_terms": [], "name": "Ric3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026161": {"description": "FAM178 family", "go_ids": [], "go_terms": [], "name": "FAM178", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026162": {"description": "Myb/SANT-like DNA-binding domain-containing protein 4", "go_ids": [], "go_terms": [], "name": "MSANTD4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026163": {"description": "Nck-associated protein 5-like", "go_ids": [], "go_terms": [], "name": "Nckap5l", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026164": {"description": "Integrator complex subunit 10", "go_ids": ["GO:0032039", "GO:0016180"], "go_terms": ["GO:0032039:integrator complex:C", "GO:0016180:snRNA processing:P"], "name": "Int_cplx_su10", "pathway_ids": ["R-DME-6807505", "R-MMU-6807505", "R-DRE-6807505", "R-HSA-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR026165": {"description": "Cytoskeleton-associated protein 2 family", "go_ids": [], "go_terms": [], "name": "CKAP2_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026169": {"description": "Mitochondria-eating protein", "go_ids": ["GO:0035694", "GO:0005741"], "go_terms": ["GO:0035694:mitochondrial protein catabolic process:P", "GO:0005741:mitochondrial outer membrane:C"], "name": "MIEAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026170": {"description": "N-lysine methyltransferase FAM173A/B", "go_ids": ["GO:0016279"], "go_terms": ["GO:0016279:protein-lysine N-methyltransferase activity:F"], "name": "FAM173A/B", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR026171": {"description": "Fanconi anemia group I protein", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "FANCI", "pathway_ids": ["R-GGA-351465", "R-HSA-6796648", "R-HSA-6783310", "R-DME-6783310", "R-MMU-6783310"], "pathways": ["R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR026172": {"description": "Gamma-secretase-activating protein family", "go_ids": [], "go_terms": [], "name": "GSAP_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026173": {"description": "Sperm-associated antigen 17", "go_ids": [], "go_terms": [], "name": "SPAG17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026175": {"description": "Mirror-image polydactyly gene 1 protein", "go_ids": [], "go_terms": [], "name": "MIPOL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026178": {"description": "Junctional sarcoplasmic reticulum protein 1", "go_ids": [], "go_terms": [], "name": "JSRP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026179": {"description": "SLAIN motif-containing protein", "go_ids": [], "go_terms": [], "name": "Slain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026180": {"description": "KAT8 regulatory NSL complex subunit 1", "go_ids": ["GO:0000123"], "go_terms": ["GO:0000123:histone acetyltransferase complex:C"], "name": "NSL1", "pathway_ids": ["R-MMU-3214847", "R-HSA-3214847", "R-MMU-9772755", "R-HSA-9772755"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Family"}, "IPR026181": {"description": "Transmembrane protein 40", "go_ids": [], "go_terms": [], "name": "TMEM40", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026182": {"description": "Anaphase-promoting complex subunit 15", "go_ids": ["GO:0090266", "GO:0005680"], "go_terms": ["GO:0090266:regulation of mitotic cell cycle spindle assembly checkpoint:P", "GO:0005680:anaphase-promoting complex:C"], "name": "ANAPC15", "pathway_ids": ["R-HSA-174178", "R-RNO-2559582", "R-DRE-141430", "R-DRE-174048", "R-MMU-2467813", "R-MMU-174154", "R-BTA-179409", "R-MMU-69017", "R-BTA-141430", "R-XTR-174048", "R-DRE-2467813", "R-BTA-176409", "R-HSA-141430", "R-RNO-174154", "R-XTR-174154", "R-DRE-69017", "R-MMU-174084", "R-HSA-176408", "R-DRE-174184", "R-BTA-68867", "R-HSA-68867", "R-RNO-141430", "R-HSA-176409", "R-MMU-176409", "R-MMU-68867", "R-RNO-176412", "R-BTA-174084", "R-HSA-9687136", "R-BTA-2559582", "R-RNO-174048", "R-XTR-69017", "R-MMU-2559582", "R-RNO-179409", "R-RNO-174184", "R-MMU-141430", "R-RNO-176408", "R-BTA-69017", "R-BTA-176408", "R-XTR-179409", "R-RNO-174084", "R-XTR-174184", "R-DRE-176409", "R-RNO-2467813", "R-HSA-174048", "R-HSA-179409", "R-DRE-176412", "R-HSA-174154", "R-HSA-8853884", "R-XTR-176408", "R-HSA-2467813", "R-BTA-176412", "R-XTR-2467813", "R-MMU-179409", "R-XTR-141430", "R-RNO-174178", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-RNO-176407", "R-MMU-174048", "R-DRE-176407", "R-BTA-2467813", "R-DRE-2559582", "R-BTA-174154", "R-XTR-2559582", "R-BTA-174184", "R-HSA-174084", "R-DRE-176408", "R-HSA-176407", "R-BTA-176407", "R-BTA-174178", "R-DRE-174178", "R-HSA-176412", "R-MMU-176408", "R-DRE-174154", "R-BTA-174048", "R-XTR-176407", "R-DRE-174084", "R-MMU-176412", "R-MMU-176407", "R-MMU-174184", "R-XTR-176409", "R-XTR-176412", "R-XTR-174178", "R-XTR-174084", "R-HSA-69017", "R-RNO-68867", "R-XTR-68867", "R-DRE-179409", "R-RNO-69017", "R-DRE-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DRE-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-XTR-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-XTR-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DRE-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-RNO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-RNO-176412:r:Phosphorylation of the APC/C", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-XTR-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-XTR-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-XTR-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DRE-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-176412:r:Phosphorylation of the APC/C", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-XTR-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-XTR-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DRE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-DRE-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-XTR-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DRE-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-XTR-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DRE-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-XTR-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-XTR-176412:r:Phosphorylation of the APC/C", "R-XTR-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-XTR-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-DRE-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-68867:r:Assembly of the pre-replicative complex"], "type": "Family"}, "IPR026183": {"description": "Taxilin family", "go_ids": ["GO:0019905"], "go_terms": ["GO:0019905:syntaxin binding:F"], "name": "Taxilin_fam", "pathway_ids": ["R-HSA-449836", "R-MMU-449836"], "pathways": ["R-HSA-449836:r:Other interleukin signaling", "R-MMU-449836:r:Other interleukin signaling"], "type": "Family"}, "IPR026184": {"description": "Placenta-expressed transcript 1", "go_ids": [], "go_terms": [], "name": "PLET1", "pathway_ids": ["R-MMU-163125", "R-RNO-163125", "R-SSC-163125", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-SSC-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR026185": {"description": "Epithelial-stromal interaction protein 1", "go_ids": [], "go_terms": [], "name": "EPSTI1", "pathway_ids": ["R-MMU-9696273", "R-HSA-9696273", "R-RNO-9696273"], "pathways": ["R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle"], "type": "Family"}, "IPR026186": {"description": "Protein POF1B", "go_ids": [], "go_terms": [], "name": "POF1B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026187": {"description": "Cell death regulator Aven", "go_ids": [], "go_terms": [], "name": "Aven", "pathway_ids": ["R-HSA-111458", "R-HSA-9627069", "R-MMU-9627069", "R-MMU-111458"], "pathways": ["R-HSA-111458:r:Formation of apoptosome", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-MMU-111458:r:Formation of apoptosome"], "type": "Family"}, "IPR026188": {"description": "Lebercilin-like", "go_ids": [], "go_terms": [], "name": "Lebercilin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026189": {"description": "Cylicin", "go_ids": ["GO:0005200"], "go_terms": ["GO:0005200:structural constituent of cytoskeleton:F"], "name": "CYLC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026190": {"description": "Hypoxia-inducible lipid droplet-associated protein", "go_ids": ["GO:0010884", "GO:0001819", "GO:0008284"], "go_terms": ["GO:0010884:positive regulation of lipid storage:P", "GO:0001819:positive regulation of cytokine production:P", "GO:0008284:positive regulation of cell population proliferation:P"], "name": "Hipoxia_HILPDA", "pathway_ids": ["R-HSA-8964572", "R-MMU-8964572"], "pathways": ["R-HSA-8964572:r:Lipid particle organization", "R-MMU-8964572:r:Lipid particle organization"], "type": "Family"}, "IPR026191": {"description": "Ligand-dependent nuclear receptor-interacting factor 1", "go_ids": ["GO:0042974", "GO:0006355"], "go_terms": ["GO:0042974:nuclear retinoic acid receptor binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "LRIF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026192": {"description": "NADH-ubiquinone oxidoreductase 1 subunit C1", "go_ids": ["GO:0045271", "GO:0005739"], "go_terms": ["GO:0045271:respiratory chain complex I:C", "GO:0005739:mitochondrion:C"], "name": "NDUFC1", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR026193": {"description": "NADH-ubiquinone oxidoreductase flavoprotein 3", "go_ids": ["GO:0045271", "GO:0005739"], "go_terms": ["GO:0045271:respiratory chain complex I:C", "GO:0005739:mitochondrion:C"], "name": "NDUFV3", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-MMU-9837999", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198", "R-MMU-611105", "R-HSA-9837999", "R-RNO-9837999"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation"], "type": "Family"}, "IPR026194": {"description": "Prolactin-releasing peptide", "go_ids": ["GO:0005179"], "go_terms": ["GO:0005179:hormone activity:F"], "name": "PrRP", "pathway_ids": ["R-RNO-375276", "R-HSA-375276"], "pathways": ["R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors"], "type": "Family"}, "IPR026195": {"description": "P-selectin glycoprotein ligand 1", "go_ids": [], "go_terms": [], "name": "PSGL-1", "pathway_ids": ["R-MMU-202733", "R-HSA-202733"], "pathways": ["R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR026197": {"description": "Secretogranin III", "go_ids": [], "go_terms": [], "name": "SCG3", "pathway_ids": ["R-BTA-8957275", "R-RNO-381426", "R-MMU-114608", "R-BTA-114608", "R-DRE-114608", "R-HSA-114608", "R-HSA-381426", "R-XTR-381426", "R-RNO-8957275", "R-DRE-381426", "R-BTA-381426", "R-MMU-381426", "R-HSA-8957275", "R-XTR-114608", "R-XTR-8957275", "R-MMU-8957275", "R-DRE-8957275", "R-RNO-114608"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-XTR-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-XTR-114608:r:Platelet degranulation", "R-XTR-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation"], "type": "Family"}, "IPR026200": {"description": "TYRO protein tyrosine kinase-binding protein", "go_ids": [], "go_terms": [], "name": "Tyrobp", "pathway_ids": ["R-HSA-6798695", "R-RNO-2172127", "R-HSA-416700", "R-RNO-2424491", "R-RNO-416700", "R-HSA-2424491", "R-MMU-391160", "R-HSA-2172127", "R-MMU-2424491", "R-HSA-198933", "R-MMU-6798695", "R-RNO-391160", "R-MMU-416700", "R-MMU-2172127", "R-RNO-6798695", "R-HSA-391160"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-2172127:r:DAP12 interactions", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-416700:r:Other semaphorin interactions", "R-HSA-2424491:r:DAP12 signaling", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-HSA-2172127:r:DAP12 interactions", "R-MMU-2424491:r:DAP12 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-2172127:r:DAP12 interactions", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-391160:r:Signal regulatory protein family interactions"], "type": "Family"}, "IPR026201": {"description": "Centrosomal protein of 290kDa", "go_ids": [], "go_terms": [], "name": "Cep290", "pathway_ids": ["R-HSA-6798695", "R-MMU-380259", "R-DME-6798695", "R-HSA-380284", "R-DRE-380320", "R-MMU-380270", "R-HSA-380270", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942", "R-HSA-380320", "R-DRE-6798695", "R-MMU-8854518", "R-MMU-6798695", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Family"}, "IPR026202": {"description": "Golgin subfamily B member 1", "go_ids": ["GO:0005794"], "go_terms": ["GO:0005794:Golgi apparatus:C"], "name": "GOLGB1", "pathway_ids": ["R-HSA-6807878", "R-HSA-9703465", "R-HSA-432722"], "pathways": ["R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR026203": {"description": "Intracellular hyaluronic acid binding protein", "go_ids": ["GO:0005540"], "go_terms": ["GO:0005540:hyaluronic acid binding:F"], "name": "IHABP", "pathway_ids": ["R-MMU-8854518", "R-MMU-2160916", "R-HSA-2142845", "R-HSA-2160916", "R-HSA-8854518", "R-MMU-2142845"], "pathways": ["R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-2142845:r:Hyaluronan metabolism", "R-HSA-2160916:r:Hyaluronan degradation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2142845:r:Hyaluronan metabolism"], "type": "Family"}, "IPR026204": {"description": "GRIP1-associated protein 1", "go_ids": [], "go_terms": [], "name": "GRIPAP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026205": {"description": "Progesterone-induced-blocking factor 1", "go_ids": [], "go_terms": [], "name": "PIBF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026206": {"description": "HAUS augmin-like complex subunit 3", "go_ids": ["GO:0070652", "GO:0051225"], "go_terms": ["GO:0070652:HAUS complex:C", "GO:0051225:spindle assembly:P"], "name": "HAUS3", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-2565942", "R-MMU-8854518", "R-HSA-380284", "R-DRE-380320", "R-MMU-380270", "R-MMU-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR026207": {"description": "Interleukin-27 alpha", "go_ids": ["GO:0042129", "GO:0045523"], "go_terms": ["GO:0042129:regulation of T cell proliferation:P", "GO:0045523:interleukin-27 receptor binding:F"], "name": "IL-27_alpha", "pathway_ids": ["R-HSA-9020956", "R-MMU-9020956"], "pathways": ["R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-9020956:r:Interleukin-27 signaling"], "type": "Family"}, "IPR026209": {"description": "Wolframin family", "go_ids": [], "go_terms": [], "name": "Wolframin_fam", "pathway_ids": ["R-MMU-381426", "R-HSA-8957275", "R-HSA-381038", "R-DME-381426", "R-DME-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR026211": {"description": "GIGANTEA", "go_ids": ["GO:2000028"], "go_terms": ["GO:2000028:regulation of photoperiodism, flowering:P"], "name": "GIGANTEA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026213": {"description": "DNA-directed RNA polymerase II subunit GRINL1", "go_ids": ["GO:0006368", "GO:0005634", "GO:0003711"], "go_terms": ["GO:0006368:transcription elongation by RNA polymerase II:P", "GO:0005634:nucleus:C", "GO:0003711:transcription elongation factor activity:F"], "name": "GRINL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026218": {"description": "Heme transporter HRG", "go_ids": ["GO:0015886", "GO:0015232"], "go_terms": ["GO:0015886:heme transport:P", "GO:0015232:heme transmembrane transporter activity:F"], "name": "HRG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026220": {"description": "HTLV-1 basic zipper factor", "go_ids": ["GO:0016032"], "go_terms": ["GO:0016032:viral process:P"], "name": "HTLV1ZIPPER", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026224": {"description": "Protein DPCD", "go_ids": [], "go_terms": [], "name": "DPCD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026226": {"description": "Chromatin modification-related protein EAF5", "go_ids": [], "go_terms": [], "name": "EAF5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026229": {"description": "Vesicular, overexpressed in cancer, prosurvival protein 1", "go_ids": ["GO:0030659"], "go_terms": ["GO:0030659:cytoplasmic vesicle membrane:C"], "name": "VOPP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026234": {"description": "Mas-related G protein-coupled receptor family", "go_ids": ["GO:0004930", "GO:0016020", "GO:0007186"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F", "GO:0016020:membrane:C", "GO:0007186:G protein-coupled receptor signaling pathway:P"], "name": "MRGPCRFAMILY", "pathway_ids": ["R-HSA-375276"], "pathways": ["R-HSA-375276:r:Peptide ligand-binding receptors"], "type": "Family"}, "IPR026238": {"description": "Protein INCA1", "go_ids": [], "go_terms": [], "name": "INCA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026240": {"description": "Immunogenic miracidial antigen 8I'", "go_ids": [], "go_terms": [], "name": "Miracidia_Ag_8I'", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026241": {"description": "GLC7-interacting protein 4", "go_ids": ["GO:0005737", "GO:0008157", "GO:0019888"], "go_terms": ["GO:0005737:cytoplasm:C", "GO:0008157:protein phosphatase 1 binding:F", "GO:0019888:protein phosphatase regulator activity:F"], "name": "GIP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026243": {"description": "HAUS augmin-like complex subunit 1", "go_ids": ["GO:0051225", "GO:0070652"], "go_terms": ["GO:0051225:spindle assembly:P", "GO:0070652:HAUS complex:C"], "name": "HAUS1", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-MMU-380270", "R-HSA-380284", "R-HSA-380270", "R-RNO-5620912", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-BTA-380259", "R-RNO-380320", "R-HSA-2565942", "R-RNO-380259", "R-HSA-380320", "R-BTA-380270", "R-BTA-8854518", "R-BTA-2565942", "R-RNO-2565942", "R-BTA-5620912", "R-RNO-380284", "R-BTA-380320", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-BTA-380284", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Family"}, "IPR026245": {"description": "Protein FRG2", "go_ids": [], "go_terms": [], "name": "FRG2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026246": {"description": "Fibrous sheath-interacting protein 1", "go_ids": [], "go_terms": [], "name": "Fsip1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026247": {"description": "Endothelial cell-specific chemotaxis regulator", "go_ids": [], "go_terms": [], "name": "ECSCR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026248": {"description": "Protein Fyv8", "go_ids": [], "go_terms": [], "name": "Fyv8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026254": {"description": "E3 ubiquitin-protein ligase RNF31-like", "go_ids": ["GO:0071797", "GO:0004842"], "go_terms": ["GO:0071797:LUBAC complex:C", "GO:0004842:ubiquitin-protein transferase activity:F"], "name": "RNF31-like", "pathway_ids": ["R-MMU-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357956", "R-HSA-5357786", "R-MMU-5357905"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling"], "type": "Family"}, "IPR026255": {"description": "NAD(P) transhydrogenase, alpha subunit", "go_ids": ["GO:1902600"], "go_terms": ["GO:1902600:proton transmembrane transport:P"], "name": "NADP_transhyd_a", "pathway_ids": ["R-MMU-71403", "R-HSA-71403", "R-BTA-71403"], "pathways": ["R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Family"}, "IPR026256": {"description": "DNA transformation protein TfoX-like, gammaproteobacteria", "go_ids": ["GO:0030420"], "go_terms": ["GO:0030420:establishment of competence for transformation:P"], "name": "TfoX-like_gammaprotbact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026258": {"description": "Signal recognition particle subunit SRP68", "go_ids": ["GO:0005047", "GO:0008312", "GO:0006614", "GO:0005786", "GO:0030942"], "go_terms": ["GO:0005047:signal recognition particle binding:F", "GO:0008312:7S RNA binding:F", "GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P", "GO:0005786:signal recognition particle, endoplasmic reticulum targeting:C", "GO:0030942:endoplasmic reticulum signal sequence receptor activity:F"], "name": "SRP68", "pathway_ids": ["R-HSA-1799339", "R-MMU-1799339", "R-DME-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-CEL-1799339", "R-SPO-1799339", "R-SCE-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR026259": {"description": "Di-c-type haem protein, MauG/cytochrome c peroxidase", "go_ids": ["GO:0020037", "GO:0016491"], "go_terms": ["GO:0020037:heme binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "MauG/Cytc_peroxidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026260": {"description": "Threonine synthase, bacterial/archaeal", "go_ids": ["GO:0009088", "GO:0004795"], "go_terms": ["GO:0009088:L-threonine biosynthetic process:P", "GO:0004795:threonine synthase activity:F"], "name": "Thr_Synthase_bac/arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026262": {"description": "Antitoxin DinJ", "go_ids": ["GO:0015643", "GO:0044010", "GO:0000987"], "go_terms": ["GO:0015643:toxic substance binding:F", "GO:0044010:single-species biofilm formation:P", "GO:0000987:cis-regulatory region sequence-specific DNA binding:F"], "name": "DinJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026263": {"description": "Alkaline phosphatase, prokaryotic", "go_ids": ["GO:0004035"], "go_terms": ["GO:0004035:alkaline phosphatase activity:F"], "name": "Alkaline_phosphatase_prok", "pathway_ids": ["PWY-5491"], "pathways": ["PWY-5491:t:diethylphosphate degradation"], "type": "Family"}, "IPR026265": {"description": "Lipopolysaccharide export system protein LptC", "go_ids": ["GO:0140332", "GO:0015920", "GO:0005886"], "go_terms": ["GO:0140332:lipopolysaccharide transfer activity:F", "GO:0015920:lipopolysaccharide transport:P", "GO:0005886:plasma membrane:C"], "name": "LptC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026266": {"description": "L-arabinose-binding periplasmic protein", "go_ids": ["GO:0042882"], "go_terms": ["GO:0042882:L-arabinose transmembrane transport:P"], "name": "AraF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026267": {"description": "Inner membrane protein YgjV", "go_ids": [], "go_terms": [], "name": "YgjV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026268": {"description": "Protein RseC", "go_ids": [], "go_terms": [], "name": "RseC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026269": {"description": "Tat proofreading chaperone DmsD-type", "go_ids": [], "go_terms": [], "name": "DmsD-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026270": {"description": "Signal recognition particle, SRP72 subunit", "go_ids": ["GO:0006614"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P"], "name": "SRP72", "pathway_ids": ["R-HSA-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-CEL-1799339", "R-SPO-1799339", "R-SCE-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR026271": {"description": "PRAME", "go_ids": ["GO:0008284", "GO:0045892", "GO:0045596", "GO:0043066"], "go_terms": ["GO:0008284:positive regulation of cell population proliferation:P", "GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0045596:negative regulation of cell differentiation:P", "GO:0043066:negative regulation of apoptotic process:P"], "name": "PRAME", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026272": {"description": "Immunity protein SdpI", "go_ids": [], "go_terms": [], "name": "SdpI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026273": {"description": "Low specificity L-threonine aldolase, bacteria", "go_ids": ["GO:0006567", "GO:0004793"], "go_terms": ["GO:0006567:L-threonine catabolic process:P", "GO:0004793:threonine aldolase activity:F"], "name": "Low_specificity_L-TA_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026274": {"description": "tRNA wybutosine synthesizing protein 2", "go_ids": ["GO:0031591", "GO:0008757"], "go_terms": ["GO:0031591:wybutosine biosynthetic process:P", "GO:0008757:S-adenosylmethionine-dependent methyltransferase activity:F"], "name": "tRNA_wybutosine_synth_prot_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026275": {"description": "Glyoxalase/dioxygenase/EhpR", "go_ids": [], "go_terms": [], "name": "Glyoxalase/dOase/EhpR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026276": {"description": "Baseplate protein GpP", "go_ids": [], "go_terms": [], "name": "Baseplate_GpP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026278": {"description": "Potassium/proton antiporter subunit KhtT", "go_ids": [], "go_terms": [], "name": "KhtT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026279": {"description": "Sigma-E factor negative regulatory protein RseA", "go_ids": ["GO:0016989"], "go_terms": ["GO:0016989:sigma factor antagonist activity:F"], "name": "RseA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026280": {"description": "Tissue plasminogen activator", "go_ids": ["GO:0004252", "GO:0031639", "GO:0006508"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0031639:plasminogen activation:P", "GO:0006508:proteolysis:P"], "name": "Tissue_plasm_act", "pathway_ids": ["R-HSA-186797", "R-MMU-75205", "R-RNO-75205", "R-SSC-75205", "R-MMU-186797", "R-HSA-75205", "R-SSC-186797", "R-RNO-186797"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-SSC-75205:r:Dissolution of Fibrin Clot", "R-MMU-186797:r:Signaling by PDGF", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-SSC-186797:r:Signaling by PDGF", "R-RNO-186797:r:Signaling by PDGF"], "type": "Family"}, "IPR026281": {"description": "HTH-type transcriptional regulator RamB", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "HTH_RamB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026282": {"description": "GsbR-like", "go_ids": [], "go_terms": [], "name": "GsbR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026283": {"description": "Beta-galactosidase 1-like", "go_ids": ["GO:0004565"], "go_terms": ["GO:0004565:beta-galactosidase activity:F"], "name": "B-gal_1-like", "pathway_ids": ["PWY-6807", "R-DDI-9840310", "R-MMU-9840310", "R-HSA-2024101", "R-HSA-9953111", "R-HSA-6798695", "R-DDI-6798695", "R-RNO-9840310", "R-HSA-9840310", "R-HSA-2022857", "R-RNO-2022857", "R-MMU-2022857", "R-RNO-2024101", "R-MMU-4085001", "R-MMU-2024101", "R-HSA-4341670", "R-MMU-6798695", "R-DDI-2022857", "R-HSA-4085001", "R-DDI-2024101", "R-HSA-2206308"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-9953111:r:MPS IV - Morquio syndrome B (CS/DS degradation)", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-2022857:r:Keratan sulfate degradation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-RNO-2024101:r:CS/DS degradation", "R-MMU-4085001:r:Sialic acid metabolism", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-4341670:r:Defective NEU1 causes sialidosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-2022857:r:Keratan sulfate degradation", "R-HSA-4085001:r:Sialic acid metabolism", "R-DDI-2024101:r:CS/DS degradation", "R-HSA-2206308:r:MPS IV - Morquio syndrome B (Keratin metabolism)"], "type": "Family"}, "IPR026284": {"description": "Alpha-2-macroglobulin, proteobacteria", "go_ids": [], "go_terms": [], "name": "A2MG_proteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026285": {"description": "TenA_E protein", "go_ids": [], "go_terms": [], "name": "TenA_E", "pathway_ids": ["PWY-6899", "PWY-7356"], "pathways": ["PWY-6899:t:base-degraded thiamine salvage", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)"], "type": "Family"}, "IPR026286": {"description": "Maleate isomerase/Arylmalonate decarboxylase", "go_ids": [], "go_terms": [], "name": "MaiA/AMDase", "pathway_ids": ["PWY-722", "PWY-6993", "PWY-7128", "PWY-5033", "PWY-8085"], "pathways": ["PWY-722:t:nicotinate degradation I", "PWY-6993:t:nicotine degradation II (pyrrolidine pathway)", "PWY-7128:t:nicotine degradation III (VPP pathway)", "PWY-5033:t:nicotinate degradation II", "PWY-8085:t:picolinate degradation"], "type": "Family"}, "IPR026287": {"description": "Protein adenylyltransferase SoFic-like", "go_ids": [], "go_terms": [], "name": "SoFic-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026288": {"description": "Submaxillary gland androgen-regulated protein like", "go_ids": [], "go_terms": [], "name": "SMR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026289": {"description": "Solute binding protein, TakP-like", "go_ids": ["GO:0031317"], "go_terms": ["GO:0031317:tripartite ATP-independent periplasmic transporter complex:C"], "name": "SBP_TakP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026295": {"description": "Coiled-coil domain-containing protein 81", "go_ids": [], "go_terms": [], "name": "CCD81", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026296": {"description": "CXC chemokine 16", "go_ids": ["GO:0034097", "GO:0008009", "GO:0005044", "GO:0005041", "GO:0006898", "GO:0006935", "GO:0030307", "GO:0034341", "GO:0034612", "GO:0048247", "GO:0030335"], "go_terms": ["GO:0034097:response to cytokine:P", "GO:0008009:chemokine activity:F", "GO:0005044:scavenger receptor activity:F", "GO:0005041:low-density lipoprotein particle receptor activity:F", "GO:0006898:receptor-mediated endocytosis:P", "GO:0006935:chemotaxis:P", "GO:0030307:positive regulation of cell growth:P", "GO:0034341:response to type II interferon:P", "GO:0034612:response to tumor necrosis factor:P", "GO:0048247:lymphocyte chemotaxis:P", "GO:0030335:positive regulation of cell migration:P"], "name": "CXCL16", "pathway_ids": ["R-BTA-418594", "R-HSA-418594", "R-HSA-380108", "R-BTA-380108", "R-SSC-380108", "R-MMU-380108", "R-SSC-418594", "R-RNO-380108", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-380108:r:Chemokine receptors bind chemokines", "R-BTA-380108:r:Chemokine receptors bind chemokines", "R-SSC-380108:r:Chemokine receptors bind chemokines", "R-MMU-380108:r:Chemokine receptors bind chemokines", "R-SSC-418594:r:G alpha (i) signalling events", "R-RNO-380108:r:Chemokine receptors bind chemokines", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR026297": {"description": "FMRFamide-related peptide/Growth hormone-releasing peptide", "go_ids": ["GO:0007218"], "go_terms": ["GO:0007218:neuropeptide signaling pathway:P"], "name": "FMRFamide-related/fGRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026298": {"description": "Bcl-2 family", "go_ids": ["GO:0042981"], "go_terms": ["GO:0042981:regulation of apoptotic process:P"], "name": "Bcl-2_fam", "pathway_ids": ["R-HSA-114294", "R-MMU-9648002", "R-MMU-844455", "R-HSA-5620971", "R-BTA-6804114", "R-RNO-844455", "R-RNO-6804114", "R-MMU-111452", "R-MMU-111453", "R-RNO-111453", "R-BTA-114294", "R-HSA-9818030", "R-HSA-111453", "R-BTA-5620971", "R-RNO-5620971", "R-MMU-111457", "R-BTA-111457", "R-HSA-8878166", "R-RNO-9648002", "R-HSA-9824594", "R-HSA-844455", "R-HSA-9018519", "R-HSA-9692913", "R-HSA-9603505", "R-HSA-9702518", "R-HSA-111447", "R-HSA-6785807", "R-HSA-9634638", "R-GGA-844455", "R-CEL-9648002", "R-RNO-111457", "R-HSA-9725371", "R-MMU-111447", "R-HSA-111457", "R-HSA-111452", "R-RNO-114294", "R-HSA-6804114", "R-HSA-6803204", "R-GGA-111453", "R-MMU-5620971", "R-CEL-111453", "R-MMU-114294", "R-HSA-9648002", "R-HSA-9725370", "R-MMU-6804114"], "pathways": ["R-HSA-114294:r:Activation, translocation and oligomerization of BAX", "R-MMU-9648002:r:RAS processing", "R-MMU-844455:r:The NLRP1 inflammasome", "R-HSA-5620971:r:Pyroptosis", "R-BTA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-844455:r:The NLRP1 inflammasome", "R-RNO-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-111452:r:Activation and oligomerization of BAK protein", "R-MMU-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-RNO-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-BTA-114294:r:Activation, translocation and oligomerization of BAX", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-BTA-5620971:r:Pyroptosis", "R-RNO-5620971:r:Pyroptosis", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-BTA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-RNO-9648002:r:RAS processing", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-844455:r:The NLRP1 inflammasome", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-GGA-844455:r:The NLRP1 inflammasome", "R-CEL-9648002:r:RAS processing", "R-RNO-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-111452:r:Activation and oligomerization of BAK protein", "R-RNO-114294:r:Activation, translocation and oligomerization of BAX", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-GGA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-MMU-5620971:r:Pyroptosis", "R-CEL-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-MMU-114294:r:Activation, translocation and oligomerization of BAX", "R-HSA-9648002:r:RAS processing", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "type": "Family"}, "IPR026299": {"description": "Mitochondrial 28S ribosomal protein S31", "go_ids": ["GO:0003735", "GO:0005763"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005763:mitochondrial small ribosomal subunit:C"], "name": "MRP-S31", "pathway_ids": ["R-CEL-9937383", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-CEL-5389840", "R-HSA-5419276", "R-MMU-5419276", "R-CEL-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-RNO-5389840"], "pathways": ["R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR026300": {"description": "CWF11 family", "go_ids": ["GO:0000398", "GO:0005681"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P", "GO:0005681:spliceosomal complex:C"], "name": "CWF11_fam", "pathway_ids": ["R-HSA-6781827", "R-MMU-6782135", "R-SPO-6782210", "R-MMU-72163", "R-HSA-6782210", "R-MMU-6782210", "R-HSA-6782135", "R-SPO-6782135", "R-SPO-72163", "R-HSA-9918481", "R-HSA-6781823", "R-HSA-72163", "R-MMU-6781823"], "pathways": ["R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex"], "type": "Family"}, "IPR026302": {"description": "NEDD4-binding protein 2-like 1/3", "go_ids": [], "go_terms": [], "name": "NEDD4-bd_p2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026306": {"description": "RSBN1/Dpy-21/CEP530", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "RSBN1/Dpy-2/CEP530", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR026307": {"description": "Transmembrane protein 132", "go_ids": [], "go_terms": [], "name": "TMEM132", "pathway_ids": ["R-RNO-381426", "R-RNO-8957275", "R-MMU-381426", "R-DRE-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-DRE-8957275"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8957275:r:Post-translational protein phosphorylation"], "type": "Family"}, "IPR026314": {"description": "YLP motif-containing protein 1", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "YLP_motif_con_p1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026315": {"description": "Out at first protein", "go_ids": [], "go_terms": [], "name": "Oaf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026316": {"description": "KAT8 regulatory NSL complex subunit 2", "go_ids": ["GO:0000123"], "go_terms": ["GO:0000123:histone acetyltransferase complex:C"], "name": "NSL2", "pathway_ids": ["R-MMU-3214847", "R-BTA-9772755", "R-MMU-9772755", "R-HSA-3214847", "R-RNO-3214847", "R-HSA-9772755", "R-RNO-9772755", "R-BTA-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-BTA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR026317": {"description": "Protein C10", "go_ids": [], "go_terms": [], "name": "Grcc10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026319": {"description": "Zinc finger C2HC domain-containing protein 1A/B-like", "go_ids": [], "go_terms": [], "name": "ZC2HC1A/B-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026320": {"description": "Proline-rich protein 14", "go_ids": [], "go_terms": [], "name": "PRR14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026321": {"description": "Coiled-coil domain-containing protein 134", "go_ids": [], "go_terms": [], "name": "CC134", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026322": {"description": "Geopeptide radical SAM maturase, putative", "go_ids": [], "go_terms": [], "name": "Geopep_mat_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026323": {"description": "Exosortase-related protein XrtF", "go_ids": [], "go_terms": [], "name": "Exosortase-related_prot_XrtF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026324": {"description": "Haem oxygenase, HugZ", "go_ids": [], "go_terms": [], "name": "Haem_oxygenase_HugZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026325": {"description": "Protein of unknown function DUF932", "go_ids": [], "go_terms": [], "name": "DUF932", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026327": {"description": "Methyl-coenzyme M reductase, protein C-like", "go_ids": [], "go_terms": [], "name": "Me_CoM_Rdtase_prot-C-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026328": {"description": "Formylmethanofuran dehydrogenase, subunit E", "go_ids": [], "go_terms": [], "name": "FmdE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026331": {"description": "Integrating conjugative element protein PFL_4710", "go_ids": [], "go_terms": [], "name": "PFL_4710", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026332": {"description": "Anaerobilin synthase HutW", "go_ids": [], "go_terms": [], "name": "HutW", "pathway_ids": [], "pathways": [], "type": "Family"}, 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"Methyltr_grasp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026449": {"description": "ATP-grasp ribosomal peptide maturase, SAV-5884 family", "go_ids": [], "go_terms": [], "name": "GRASP_SAV_5884", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026450": {"description": "MAST domain", "go_ids": [], "go_terms": [], "name": "MAST_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026451": {"description": "Class III signal peptide protein, archaeosortase D/PIP-CTERM system", "go_ids": [], "go_terms": [], "name": "ClassIII_w_PIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026452": {"description": "Surface glycoprotein signal peptide", "go_ids": [], "go_terms": [], "name": "Surf_glycop_sig_pep", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026453": {"description": "PGF-pre-PGF domain", "go_ids": [], "go_terms": [], "name": "PGF_pre_PGF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026454": {"description": "Rhombotarget A", "go_ids": [], "go_terms": [], "name": "Rhombotarget_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026455": {"description": "ATP-GRASP peptide maturase, grasp-with-spasm system", "go_ids": [], "go_terms": [], "name": "GRASP_w_spasm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026456": {"description": "Glycosyltransferase AglJ", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "GCTrfase_AglJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026457": {"description": "CSLREA domain", "go_ids": [], "go_terms": [], "name": "CSLREA_Nterm", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026458": {"description": "Cell surface glycoprotein, halobacteria", "go_ids": [], "go_terms": [], "name": "Csg_halobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026459": {"description": "Ribonucleotide reductase, class 1b, subunit NrdE", "go_ids": [], "go_terms": [], "name": "RNR_1b_NrdE", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Family"}, "IPR026460": {"description": "Aldehyde dehydrogenase, Rv0768 family", "go_ids": [], "go_terms": [], "name": "Aldehyde_dehydrogenase_Rv0768", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026461": {"description": "Transferase 2, rSAM/selenodomain-associated", "go_ids": [], "go_terms": [], "name": "Trfase_2_rSAM/seldom_assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026463": {"description": "Chitooligosaccharide synthase NodC", "go_ids": [], "go_terms": [], "name": "Chitooligosach_Synthase_NodC", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype 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"PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica 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"PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype 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"PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR026464": {"description": "Nitrous oxide reductase family maturation protein NosD", "go_ids": [], "go_terms": [], "name": "NosD_copper_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026465": {"description": "Serine-rich repeat adhesion glycoprotein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ser_adhes_glycop_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026466": {"description": "Fimbrial isopeptide formation D2 domain", "go_ids": [], "go_terms": [], "name": "Fim_isopep_form_D2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026467": {"description": "Ser/Gly rich, Cys interspersed, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ser/Gly_Cys_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026468": {"description": "Nitrous-oxide reductase, Sec-dependent", "go_ids": [], 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"PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR026471": {"description": "Zinc metalloproteinase 18-residue repeat", "go_ids": [], "go_terms": [], "name": "Zmp_18_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR026472": {"description": "Membrane glycoprotein E3 CR1-alpha-1", "go_ids": [], "go_terms": [], "name": "E3_CR1-alpha-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026473": {"description": "Cyanobactin biosynthesis protein, PatB/AcyB/McaB family", "go_ids": [], "go_terms": [], "name": "PatB_AcyB_McaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026474": {"description": "Plantazolicin", "go_ids": [], "go_terms": [], "name": "Plantazolicin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026475": {"description": "Archaetidylserine synthase", "go_ids": [], "go_terms": [], "name": "Archaetidylserine_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026476": {"description": "Sarcinarray family protein", "go_ids": [], "go_terms": [], "name": "Sarcinarray_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026477": {"description": "XrtJ-associated TM-motif-TM protein", "go_ids": [], "go_terms": [], "name": "Targ_of_XrtJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026478": {"description": "Exosortase J", "go_ids": [], "go_terms": [], "name": "Exosortase_J", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026479": {"description": "Glycopeptide, sublancin family", "go_ids": [], "go_terms": [], "name": "Glycopep_SunS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026481": {"description": "CCGSCS motif protein", "go_ids": [], "go_terms": [], "name": "CCGSCS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026482": {"description": "Nif11-class peptide radical SAM maturase 3", "go_ids": [], "go_terms": [], "name": "rSAM_nif11_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026483": {"description": "CRISPR-associated protein Csx17, subtype I-G", "go_ids": [], "go_terms": [], "name": "Cas_Csx17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026484": {"description": "Cys-Xaa-Xaa-Xaa repeat radical SAM target protein", "go_ids": [], "go_terms": [], "name": "Syntroph_Cxxx", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026485": {"description": "Archaeosortase family protein ArtE", "go_ids": [], "go_terms": [], "name": "Archaeo_ArtE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026486": {"description": "Uncharacterised protein AF_0576", "go_ids": [], "go_terms": [], "name": "CHP_AF_0576", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026487": {"description": "Sporadically distributed protein CHP04141", "go_ids": [], "go_terms": [], "name": "CHP04141", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026488": {"description": "Exosortase C, VPDSG-CTERM-specific", "go_ids": [], "go_terms": [], "name": "Exosort_VPDSG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026491": {"description": "Exosortase D, VPLPA-CTERM-specific", "go_ids": [], "go_terms": [], "name": "ExosortD_VPLPA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026492": {"description": "Cyanoexosortase B", "go_ids": [], "go_terms": [], "name": "Cyanoexo_CrtB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026493": {"description": "Cys-rich peptide", "go_ids": [], "go_terms": [], "name": "Cys-rich_pep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026494": {"description": "Ribonucleoside-diphosphate reductase subunit beta", "go_ids": ["GO:0005971", "GO:0009263"], "go_terms": ["GO:0005971:ribonucleoside-diphosphate reductase complex:C", "GO:0009263:deoxyribonucleotide biosynthetic process:P"], "name": "RNR_NrdF-like", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Family"}, "IPR026495": {"description": "PIP-CTERM protein sorting domain", "go_ids": [], "go_terms": [], "name": "PIP_CTERM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026496": {"description": "Putative ATP-grasp target RiPP, Streptomyces", "go_ids": [], "go_terms": [], "name": "GRASP_targ_Streptomyces", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026497": {"description": "SPASM domain peptide maturase, GRASP-with-SPASM system", "go_ids": [], "go_terms": [], "name": "GRASP-with-SPASM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026498": {"description": "Grasp-with-spasm leader A domain", "go_ids": [], "go_terms": [], "name": "Grasp_w_spasm_A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026499": {"description": "Peptide S-glycosyltransferase, SunS family", "go_ids": ["GO:0018280"], "go_terms": ["GO:0018280:protein S-linked glycosylation:P"], "name": "S_glycosyl_SunS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026500": {"description": "Dendrin", "go_ids": [], "go_terms": [], "name": "Dendrin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026501": {"description": "Limbin/EvC complex member EVC", "go_ids": ["GO:0007224"], "go_terms": ["GO:0007224:smoothened signaling pathway:P"], "name": "Limbin/EVC", "pathway_ids": ["R-MMU-5632684", "R-HSA-5635838", "R-HSA-5632684"], "pathways": ["R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-5635838:r:Activation of SMO", "R-HSA-5632684:r:Hedgehog 'on' state"], "type": "Family"}, "IPR026502": {"description": "Histone RNA stem-loop-binding protein SLBP1/SLBP2", "go_ids": ["GO:0003729"], "go_terms": ["GO:0003729:mRNA binding:F"], "name": "SLBP1/SLBP2", "pathway_ids": ["R-DME-159230", "R-HSA-159230", "R-CEL-159230", "R-MMU-77588", "R-HSA-77588", "R-MMU-73856", "R-HSA-73856", "R-DME-77588", "R-DME-73856", "R-CEL-73856", "R-CEL-77588", "R-MMU-159230"], "pathways": ["R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the 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F3/F4", "go_ids": [], "go_terms": [], "name": "Solute_c_fam_35_mem_F3/F4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026506": {"description": "GDP-L-galactose/GDP-D-glucose phosphorylase", "go_ids": ["GO:0080048"], "go_terms": ["GO:0080048:GDP-D-glucose phosphorylase activity:F"], "name": "GDPGP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026507": {"description": "Piercer of microtubule wall 1/2", "go_ids": ["GO:0005879", "GO:0035082"], "go_terms": ["GO:0005879:axonemal microtubule:C", "GO:0035082:axoneme assembly:P"], "name": "PIRC1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026508": {"description": "Transmembrane protein 164", "go_ids": [], "go_terms": [], "name": "TMEM164", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026509": {"description": "Transmembrane protein 183", "go_ids": [], "go_terms": [], "name": "TMEM183", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026510": {"description": "Peroxisomal membrane protein 11C, metazoa", "go_ids": [], "go_terms": [], "name": "PEX11C_met", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026511": {"description": "Parathyroid hormone-responsive B1", "go_ids": ["GO:0034464"], "go_terms": ["GO:0034464:BBSome:C"], "name": "PTHB1", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Family"}, "IPR026512": {"description": "RGS7BP/RGS9BP family", "go_ids": [], "go_terms": [], "name": "RGS7BP/RGS9BP", "pathway_ids": ["R-HSA-2514859", "R-MMU-2514859", "R-BTA-2514859"], "pathways": ["R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Family"}, "IPR026516": {"description": "THAP domain-containing protein 1/10", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "THAP1/10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026519": {"description": "THAP domain-containing protein 7", "go_ids": [], "go_terms": [], "name": "THAP7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026520": {"description": "THAP domain-containing protein 3", "go_ids": [], "go_terms": [], "name": "THAP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026521": {"description": "THAP domain-containing protein 2", "go_ids": [], "go_terms": [], "name": "THAP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026523": {"description": "Paraneoplastic antigen Ma", "go_ids": [], "go_terms": [], "name": "PNMA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026524": {"description": "Lymphocyte antigen 6 complex locus protein G6d/G6f", "go_ids": [], "go_terms": [], "name": "LY6G6d/LY6G6f", "pathway_ids": ["R-HSA-114608", "R-MMU-163125", "R-RNO-163125", "R-RNO-114608", "R-HSA-163125"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-114608:r:Platelet degranulation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR026526": {"description": "Coiled-coil domain-containing protein 8", "go_ids": [], "go_terms": [], "name": "CCDC8", "pathway_ids": ["R-RNO-8951664", "R-HSA-8951664"], "pathways": ["R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation"], "type": "Family"}, "IPR026532": {"description": "Ribosome biogenesis protein BRX1", "go_ids": [], "go_terms": [], "name": "BRX1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026533": {"description": "Non-canonical purine NTP phosphatase/PRRC1", "go_ids": [], "go_terms": [], "name": "NTPase/PRRC1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026534": {"description": "Protein PRRC1", "go_ids": [], "go_terms": [], "name": "PRRC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026541": {"description": "MRG domain", "go_ids": [], "go_terms": [], "name": "MRG_dom", "pathway_ids": ["R-MMU-3214847", "R-HSA-3214847", "R-DME-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR026555": {"description": "KAT8 regulatory NSL complex subunit 3/Testis-expressed sequence 30 protein", "go_ids": [], "go_terms": [], "name": "NSL3/Tex30", "pathway_ids": ["R-MMU-3214847", "R-MMU-9772755", "R-HSA-3214847", "R-HSA-9772755", "R-RNO-3214847", "R-DRE-3214847", "R-RNO-9772755"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-3214847:r:HATs acetylate histones", "R-DRE-3214847:r:HATs acetylate histones", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Family"}, "IPR026564": {"description": "Transcriptional regulator TACO1-like, domain 3", "go_ids": [], "go_terms": [], "name": "Transcrip_reg_TACO1-like_dom3", "pathway_ids": ["R-HSA-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly"], "type": "Homologous_superfamily"}, "IPR026569": {"description": "Large ribosomal subunit protein bL28", "go_ids": ["GO:0003735"], "go_terms": ["GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_bL28", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-DME-9937383"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR026570": {"description": "Coiled-coil domain-containing protein 86", "go_ids": [], "go_terms": [], "name": "CCDC86", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026571": {"description": "Transmembrane protein 186", "go_ids": [], "go_terms": [], "name": "Tmem186", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-MMU-6799198", "R-DRE-611105", "R-DRE-6799198", "R-DME-6799198", "R-RNO-6799198", "R-HSA-6799198", "R-MMU-611105", "R-BTA-6799198", "R-DME-611105", "R-BTA-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-DRE-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR026572": {"description": "Transmembrane protein 267", "go_ids": [], "go_terms": [], "name": "TMEM267", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026574": {"description": "Modulator protein MzrA", "go_ids": [], "go_terms": [], "name": "Modulator_MzrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026576": {"description": "Proofreading thioesterase EntH", "go_ids": ["GO:0016790", "GO:0009239"], "go_terms": ["GO:0016790:thiolester hydrolase activity:F", "GO:0009239:enterobactin biosynthetic process:P"], "name": "Thioesterase_EntH", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis"], "type": "Family"}, "IPR026577": {"description": "Replication modulator SeqA, C-terminal DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "SeqA_DNA-bd_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026579": {"description": "Cell division protein FtsQ", "go_ids": ["GO:0090529"], "go_terms": ["GO:0090529:cell septum assembly:P"], "name": "FtsQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026581": {"description": "TCP10L/CENPJ", "go_ids": [], "go_terms": [], "name": "TCP10L/CENPJ", "pathway_ids": ["R-HSA-380320", "R-HSA-6804115", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-6804115", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR026584": {"description": "Rad9", "go_ids": ["GO:0030896", "GO:0006281", "GO:0000077"], "go_terms": ["GO:0030896:checkpoint clamp complex:C", "GO:0006281:DNA repair:P", "GO:0000077:DNA damage checkpoint signaling:P"], "name": "Rad9", "pathway_ids": ["R-SPO-176187", "R-HSA-5693616", "R-HSA-69473", "R-HSA-5685938", "R-RNO-5693607", "R-MMU-6804756", "R-RNO-176187", "R-MMU-5685938", "R-RNO-69473", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-RNO-5685938", "R-MMU-176187", "R-RNO-6804756", "R-HSA-176187", "R-MMU-5693607", "R-DME-176187"], "pathways": ["R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-176187:r:Activation of ATR in response to replication 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"R-HSA-9617629", "R-DRE-2151201", "R-MMU-3371453", "R-DME-204174", "R-DDI-2151201", "R-DDI-9856649", "R-HSA-9854311", "R-HSA-204174", "R-RNO-9856649", "R-RNO-427359", "R-CEL-204174", "R-HSA-9841251", "R-DME-9856649", "R-HSA-9707616", "R-HSA-2995383", "R-HSA-9764725", "R-HSA-70635", "R-MMU-2151201", "R-RNO-70635", "R-PFA-2151201", "R-MMU-70635", "R-MMU-204174", "R-RNO-9764725", "R-BTA-2151201", "R-MMU-9841251", "R-HSA-9854907", "R-DME-9841922", "R-RNO-2151201", "R-BTA-70635", "R-RNO-9841922", "R-HSA-9856649", "R-RNO-9617629", "R-DME-9617629"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-427359:r:SIRT1 negatively regulates rRNA expression", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-DRE-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-2151201:r:Transcriptional 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{"description": "Hypoxanthine/guanine phosphoribosyltransferase-like", "go_ids": [], "go_terms": [], "name": "HGPRTase-like", "pathway_ids": ["PWY-6610", "PWY-6609", "PWY-6620", "PWY-6599"], "pathways": ["PWY-6610:t:adenine salvage", "PWY-6609:t:adenine and adenosine salvage III", "PWY-6620:t:guanine and guanosine salvage I", "PWY-6599:t:guanine and guanosine salvage II"], "type": "Family"}, "IPR026607": {"description": "DMRT family", "go_ids": ["GO:0005634", "GO:0006355"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "DMRT", "pathway_ids": ["R-HSA-9690406"], "pathways": ["R-HSA-9690406:r:Transcriptional regulation of testis differentiation"], "type": "Family"}, "IPR026609": {"description": "Opalin", "go_ids": [], "go_terms": [], "name": "Opalin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026610": {"description": "3'-RNA ribose 2'-O-methyltransferase, Hen1", "go_ids": ["GO:0001510", "GO:0008171", "GO:0008173"], "go_terms": ["GO:0001510:RNA methylation:P", "GO:0008171:O-methyltransferase activity:F", "GO:0008173:RNA methyltransferase activity:F"], "name": "Hen1", "pathway_ids": ["R-HSA-5601884"], "pathways": ["R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis"], "type": "Family"}, "IPR026612": {"description": "Receptor for retinol uptake STRA6-like", "go_ids": ["GO:0034632", "GO:0038023"], "go_terms": ["GO:0034632:retinol transmembrane transporter activity:F", "GO:0038023:signaling receptor activity:F"], "name": "STRA6-like", "pathway_ids": ["R-HSA-9918449", "R-MMU-2453902", "R-DRE-2453902", "R-RNO-2453902", "R-HSA-2453902"], "pathways": ["R-HSA-9918449:r:Defective visual phototransduction due to STRA6 loss of function", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DRE-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Family"}, "IPR026614": {"description": "Angiopoietin-like protein 8", "go_ids": ["GO:0019216", "GO:0070328"], "go_terms": ["GO:0019216:regulation of lipid metabolic process:P", "GO:0070328:triglyceride homeostasis:P"], "name": "ANGPTL8", "pathway_ids": ["R-MMU-8963889", "R-HSA-8963889"], "pathways": ["R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes"], "type": "Family"}, "IPR026616": {"description": "Testis-expressed sequence 15 protein", "go_ids": ["GO:0007129", "GO:0007140", "GO:0010569"], "go_terms": ["GO:0007129:homologous chromosome pairing at meiosis:P", "GO:0007140:male meiotic nuclear division:P", "GO:0010569:regulation of double-strand break repair via homologous recombination:P"], "name": "TEX15", "pathway_ids": ["R-HSA-912446"], "pathways": ["R-HSA-912446:r:Meiotic recombination"], "type": "Family"}, "IPR026617": {"description": "Transmembrane and coiled-coil domain-containing protein 2/5", "go_ids": [], "go_terms": [], "name": "SMCO2/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026618": {"description": "M-phase-specific PLK1-interacting protein-like, vertebrate", "go_ids": [], "go_terms": [], "name": "MPLKIP-like_vertebrate", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026619": {"description": "Centrosomal protein of 95kDa", "go_ids": ["GO:0005813", "GO:0000922"], "go_terms": ["GO:0005813:centrosome:C", "GO:0000922:spindle pole:C"], "name": "CEP95", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026620": {"description": "Transmembrane protein 177", "go_ids": [], "go_terms": [], "name": "TMEM177", "pathway_ids": ["R-RNO-9864848", "R-MMU-9864848", "R-HSA-9864848", "R-DRE-9864848"], "pathways": ["R-RNO-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-HSA-9864848:r:Complex IV assembly", "R-DRE-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR026621": {"description": "Immortalization up-regulated protein", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "IMUP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026622": {"description": "Matrix-remodeling-associated protein 7", "go_ids": [], "go_terms": [], "name": "Mxra7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026623": {"description": "Mucin-like protein 3", "go_ids": [], "go_terms": [], "name": "MUCL3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026624": {"description": "Cat eye syndrome critical region protein 6", "go_ids": [], "go_terms": [], "name": "CECR6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026626": {"description": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3", "go_ids": ["GO:0045271", "GO:0005743"], "go_terms": ["GO:0045271:respiratory chain complex I:C", "GO:0005743:mitochondrial inner membrane:C"], "name": "NDUFA3", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR026627": {"description": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, animal type", "go_ids": ["GO:0045271", "GO:0005743"], "go_terms": ["GO:0045271:respiratory chain complex I:C", "GO:0005743:mitochondrial inner membrane:C"], "name": "NDUFB2_animal", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR026634": {"description": "Protein-tyrosine sulfotransferase-like", "go_ids": ["GO:0008476", "GO:0006478"], "go_terms": ["GO:0008476:protein-tyrosine sulfotransferase activity:F", "GO:0006478:peptidyl-tyrosine sulfation:P"], "name": "TPST-like", "pathway_ids": ["R-RNO-163841", "R-BTA-163841", "R-HSA-9942503", "R-HSA-9674519", "R-MMU-163841", "R-MMU-156584", "R-BTA-156584", "R-HSA-156584", "R-RNO-156584", "R-HSA-163841"], "pathways": ["R-RNO-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-BTA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-9674519:r:Defective F8 sulfation at Y1699", "R-MMU-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-MMU-156584:r:Cytosolic sulfonation of small 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"R-SCE-8856825", "R-MMU-177504", "R-BTA-432722", "R-BTA-5140745", "R-SCE-8866427", "R-HSA-8964038", "R-RNO-416993", "R-HSA-182218"], "pathways": ["R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SPO-437239:r:Recycling pathway of L1", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DDI-437239:r:Recycling pathway of L1", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-8964038:r:LDL clearance", "R-SPO-8964038:r:LDL clearance", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-MMU-8964038:r:LDL clearance", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SCE-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-BTA-2132295:r:MHC class II antigen presentation", "R-DDI-8964038:r:LDL clearance", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-437239:r:Recycling pathway of L1", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-437239:r:Recycling pathway of L1", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-HSA-8964038:r:LDL clearance", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Family"}, "IPR026740": {"description": "AP-3 complex subunit beta", "go_ids": ["GO:0030123", "GO:0016192"], "go_terms": ["GO:0030123:AP-3 adaptor complex:C", "GO:0016192:vesicle-mediated transport:P"], "name": "AP3_beta", "pathway_ids": ["R-BTA-432722", "R-HSA-6802952", "R-MMU-432722", "R-HSA-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR026741": {"description": "Protein strawberry notch", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "SNO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026742": {"description": "Centrosomal protein kizuna", "go_ids": ["GO:0007051", "GO:0005813"], "go_terms": ["GO:0007051:spindle organization:P", "GO:0005813:centrosome:C"], "name": "Centrosomal_kizuma", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026743": {"description": "Sperm equatorial segment protein 1", "go_ids": ["GO:0001669", "GO:0007342", "GO:0007340"], "go_terms": ["GO:0001669:acrosomal vesicle:C", "GO:0007342:fusion of sperm to egg plasma membrane involved in single fertilization:P", "GO:0007340:acrosome reaction:P"], "name": "Equatorial_segment", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026748": {"description": "Clarin", "go_ids": [], "go_terms": [], "name": "Clarin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026749": {"description": "Transmembrane protein 135", "go_ids": [], "go_terms": [], "name": "Tmem135", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026750": {"description": "Protein N-terminal asparagine amidohydrolase", "go_ids": ["GO:0008418"], "go_terms": ["GO:0008418:protein-N-terminal asparagine amidohydrolase activity:F"], "name": "NTAN1", "pathway_ids": ["PWY-7799"], "pathways": ["PWY-7799:t:Arg/N-end rule pathway (eukaryotic)"], "type": "Family"}, "IPR026752": {"description": "Cavin family", "go_ids": [], "go_terms": [], "name": "Cavin_fam", "pathway_ids": ["R-RNO-9013026", "R-HSA-73863", "R-HSA-8980692", "R-MMU-9013106", "R-MMU-9013026", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-73863", "R-HSA-9013026", "R-RNO-9013106", "R-RNO-73863", "R-HSA-9013106"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-9013106:r:RHOC GTPase cycle"], "type": "Family"}, "IPR026754": {"description": "Pancreatic progenitor cell differentiation and proliferation factor", "go_ids": ["GO:0030154", "GO:0007275"], "go_terms": ["GO:0030154:cell differentiation:P", "GO:0007275:multicellular organism development:P"], "name": "PPDPF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026755": {"description": "Protein FAM221A/B", "go_ids": [], "go_terms": [], "name": "Fam221a/b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026756": {"description": "Nucleolar and spindle-associated protein 1", "go_ids": ["GO:0005819", "GO:0005874", "GO:0000281", "GO:0040001", "GO:0000226"], "go_terms": ["GO:0005819:spindle:C", "GO:0005874:microtubule:C", "GO:0000281:mitotic cytokinesis:P", "GO:0040001:establishment of mitotic spindle localization:P", "GO:0000226:microtubule cytoskeleton organization:P"], "name": "NuSAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026757": {"description": "Endosome-associated-trafficking regulator 1", "go_ids": [], "go_terms": [], "name": "ENTR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026759": {"description": "Putative monooxygenase p33MONOX", "go_ids": [], "go_terms": [], "name": "P33MONOX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026762": {"description": "Spindle and kinetochore-associated protein 2", "go_ids": ["GO:0000940", "GO:0005876", "GO:0008017", "GO:0051301", "GO:0007059"], "go_terms": ["GO:0000940:outer kinetochore:C", "GO:0005876:spindle microtubule:C", "GO:0008017:microtubule binding:F", "GO:0051301:cell division:P", "GO:0007059:chromosome segregation:P"], "name": "Ska2", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-RNO-2500257", "R-DRE-2500257", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-BTA-5663220", "R-DRE-2467813", "R-DRE-141444", "R-HSA-9648025", "R-RNO-5663220", "R-MMU-68877", "R-BTA-2467813", "R-HSA-68877", "R-BTA-2500257", "R-RNO-9648025", "R-RNO-2467813", "R-DRE-5663220", "R-HSA-5663220", "R-BTA-9648025", "R-BTA-141444", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR026763": {"description": "Transmembrane protein 182", "go_ids": [], "go_terms": [], "name": "TMEM182", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026765": {"description": "Transmembrane protein 163", "go_ids": [], "go_terms": [], "name": "Tmem163", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026766": {"description": "Protein FAM133", "go_ids": [], "go_terms": [], "name": "Fam133", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026767": {"description": "Transmembrane protein 151", "go_ids": [], "go_terms": [], "name": "Tmem151", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026768": {"description": "Yippee homolog double zinc finger protein", "go_ids": [], "go_terms": [], "name": "YPEH2ZP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026769": {"description": "MICOS complex subunit Mic13", "go_ids": [], "go_terms": [], "name": "Mic13", "pathway_ids": ["R-HSA-8949613"], "pathways": ["R-HSA-8949613:r:Cristae formation"], "type": "Family"}, "IPR026770": {"description": "Ribonuclease kappa", "go_ids": ["GO:0090304", "GO:0004521"], "go_terms": ["GO:0090304:nucleic acid metabolic process:P", "GO:0004521:RNA endonuclease activity:F"], "name": "RNase_K", "pathway_ids": ["R-HSA-9918485"], "pathways": ["R-HSA-9918485:r:Dengue Virus Attachment and Entry"], "type": "Family"}, "IPR026771": {"description": "Transmembrane protein 218", "go_ids": [], "go_terms": [], "name": "Tmem218", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026772": {"description": "Fin bud initiation factor", "go_ids": [], "go_terms": [], "name": "Fibin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026775": {"description": "Zygote arrest protein 1", "go_ids": [], "go_terms": [], "name": "Zar1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026776": {"description": "UPF0729 protein C18orf32-like", "go_ids": [], "go_terms": [], "name": "UPF0729_C18orf32-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026777": {"description": "Plasma membrane fusion protein PRM1", "go_ids": ["GO:0043332"], "go_terms": ["GO:0043332:mating projection tip:C"], "name": "PRM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026778": {"description": "MLLT11 family", "go_ids": ["GO:0097190"], "go_terms": ["GO:0097190:apoptotic signaling pathway:P"], "name": "MLLT11_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026779": {"description": "Calcium/calmodulin-dependent protein kinase II inhibitor", "go_ids": ["GO:0004860"], "go_terms": ["GO:0004860:protein kinase inhibitor activity:F"], "name": "Camk2n", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026780": {"description": "Proline-rich nuclear receptor coactivator 1/2", "go_ids": [], "go_terms": [], "name": "PNRC1/2", "pathway_ids": ["R-RNO-975957", "R-XTR-975957", "R-HSA-975957", "R-DRE-975957", "R-BTA-975957", "R-MMU-975957"], "pathways": ["R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Family"}, "IPR026782": {"description": "Protein FAM131", "go_ids": [], "go_terms": [], "name": "FAM131", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Family"}, "IPR026784": {"description": "Constitutive coactivator of PPAR-gamma", "go_ids": [], "go_terms": [], "name": "Coact_PPARg", "pathway_ids": ["R-HSA-1989781", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR026788": {"description": "Transmembrane protein 141", "go_ids": [], "go_terms": [], "name": "Tmem141", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026791": {"description": "Dedicator of cytokinesis", "go_ids": ["GO:0005085", "GO:0007264"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0007264:small GTPase-mediated signal transduction:P"], "name": "DOCK", "pathway_ids": ["R-HSA-9013409", "R-HSA-6798695", "R-HSA-8875555", "R-MMU-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-983231", "R-HSA-418885", "R-MMU-4420097", "R-HSA-8849471", "R-HSA-4420097", "R-HSA-9032759", "R-HSA-9013423", "R-SCE-9013149", "R-HSA-9013148", "R-HSA-164944", "R-DRE-9013149", "R-HSA-9013408", "R-MMU-8849471", "R-HSA-983231", "R-HSA-2029482", "R-MMU-2029482", "R-HSA-9013404", "R-DRE-983231", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-MMU-8875555", "R-HSA-8980692", "R-MMU-9013149", "R-MMU-9032759", "R-MMU-6798695", "R-HSA-9664422", "R-SCE-983231", "R-MMU-418885"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-164944:r:Nef and signal transduction", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Family"}, "IPR026794": {"description": "Adipose-secreted signaling protein", "go_ids": [], "go_terms": [], "name": "ADISSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026795": {"description": "Shiftless antiviral inhibitor of ribosomal frameshifting", "go_ids": [], "go_terms": [], "name": "SHFL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026797": {"description": "HAUS augmin-like complex subunit 6", "go_ids": ["GO:0070652", "GO:0051225"], "go_terms": ["GO:0070652:HAUS complex:C", "GO:0051225:spindle assembly:P"], "name": "HAUS_6", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-DRE-380320", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR026801": {"description": "Transmembrane protein 160", "go_ids": [], "go_terms": [], "name": "TMEM160", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026802": {"description": "Odontogenic ameloblast-associated protein", "go_ids": [], "go_terms": [], "name": "Odam", "pathway_ids": ["R-HSA-977225"], "pathways": ["R-HSA-977225:r:Amyloid fiber formation"], "type": "Family"}, "IPR026805": {"description": "GW182, middle domain", "go_ids": [], "go_terms": [], "name": "GW182_M_dom", "pathway_ids": ["R-HSA-8853884", "R-HSA-9824594", "R-HSA-9839394", "R-HSA-9022692", "R-MMU-426496", "R-HSA-2559580", "R-HSA-8936459", "R-HSA-8943723", "R-HSA-2559585", "R-HSA-8948700", "R-DME-5578749", "R-HSA-5628897", "R-HSA-8934593", "R-HSA-1912408", "R-HSA-9764562", "R-HSA-9725371", "R-HSA-9768778", "R-HSA-5687128", "R-HSA-9759811", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-4086398", "R-HSA-426496", "R-HSA-9029569", "R-DME-426496", "R-HSA-9018519"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DME-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR026806": {"description": "Protein CDV3", "go_ids": [], "go_terms": [], "name": "CDV3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026811": {"description": "Cip1-interacting zinc finger protein", "go_ids": [], "go_terms": [], "name": "CIZ1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026816": {"description": "Flavodoxin domain", "go_ids": [], "go_terms": [], "name": "Flavodoxin_dom", "pathway_ids": ["PWY-5531"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)"], "type": "Domain"}, "IPR026817": {"description": "Guanine nucleotide exchange factor Ect2", "go_ids": ["GO:0005096", "GO:0005085", "GO:0005634", "GO:0005737", "GO:0043547", "GO:2000431"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0005634:nucleus:C", "GO:0005737:cytoplasm:C", "GO:0043547:positive regulation of GTPase activity:P", "GO:2000431:regulation of cytokinesis, actomyosin contractile ring assembly:P"], "name": "Ect2", "pathway_ids": ["R-HSA-193648", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013026", "R-MMU-416482", "R-MMU-8980692", "R-MMU-193648", "R-HSA-9013148", "R-HSA-9013026", "R-HSA-416482", "R-MMU-9013148", "R-MMU-9013149"], "pathways": ["R-HSA-193648:r:NRAGE signals death 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"R-HSA-5358747", "R-RNO-196299", "R-CEL-196299", "R-HSA-5339716", "R-HSA-5467337", "R-MMU-4641262", "R-HSA-4641262", "R-HSA-111465", "R-MMU-111465", "R-RNO-3769402", "R-RNO-5689896", "R-HSA-5467333", "R-RNO-195253", "R-MMU-195253", "R-HSA-195253"], "pathways": ["R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467333:r:APC truncation mutants are not K63 polyubiquitinated", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Family"}, "IPR026820": {"description": "Iminophenyl-pyruvate dimer synthase", "go_ids": [], "go_terms": [], "name": "VioB/RebD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026822": {"description": "Spp2/MOS2, G-patch domain", "go_ids": [], "go_terms": [], "name": "Spp2/MOS2_G-patch", "pathway_ids": ["R-HSA-9918481", "R-HSA-72163", "R-MMU-72163", "R-CEL-72163"], "pathways": ["R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR026823": {"description": "Complement Clr-like EGF domain", "go_ids": [], "go_terms": [], 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uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-MMU-1566948:r:Elastic fibre formation", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-CEL-216083:r:Integrin cell surface interactions", "R-MMU-3000157:r:Laminin interactions", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-BTA-1566948:r:Elastic fibre formation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-RNO-1566948:r:Elastic fibre formation", "R-HSA-9758890:r:Transport of RCbl within the body", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-9758890:r:Transport of RCbl within the body", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR026825": {"description": "Vacuole morphology and inheritance protein 14", "go_ids": ["GO:0070772", "GO:0006661"], "go_terms": ["GO:0070772:PAS complex:C", "GO:0006661:phosphatidylinositol biosynthetic process:P"], "name": "Vac14", "pathway_ids": ["R-HSA-1660517", "R-RNO-1660517", "R-MMU-1660517", "R-RNO-1660516", "R-MMU-1660516", "R-MMU-1660514", "R-HSA-1660514", "R-RNO-1660514", "R-HSA-1660516"], "pathways": ["R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane"], "type": "Family"}, "IPR026828": {"description": "Suppressor APC domain-containing protein 1/2", "go_ids": [], "go_terms": [], "name": "SAPC2_1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026831": {"description": "Adenomatous polyposis coli protein", "go_ids": [], "go_terms": [], "name": "APC_dom", "pathway_ids": ["R-HSA-5358751", "R-HSA-5358752", "R-HSA-5358749", "R-MMU-3769402", "R-MMU-196299", "R-HSA-3769402", "R-RNO-4641262", "R-HSA-5689896", "R-HSA-5467348", "R-MMU-5689896", "R-HSA-196299", "R-HSA-5467340", "R-RNO-111465", "R-HSA-5358747", "R-RNO-196299", "R-HSA-5339716", "R-HSA-5467337", "R-MMU-4641262", "R-HSA-4641262", "R-HSA-111465", "R-MMU-111465", "R-RNO-3769402", "R-RNO-5689896", "R-HSA-5467333", "R-RNO-195253", "R-MMU-195253", "R-HSA-195253"], "pathways": ["R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467333:r:APC truncation mutants are not K63 polyubiquitinated", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Homologous_superfamily"}, "IPR026832": {"description": "Asteroid", "go_ids": [], "go_terms": [], "name": "Asteroid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026834": {"description": "LHH", "go_ids": [], "go_terms": [], "name": "LHH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026835": {"description": "Toxin YqcG, C-terminal", "go_ids": [], "go_terms": [], "name": "YqcG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026838": {"description": "Endospore coat-associated protein YheC/D", "go_ids": [], "go_terms": [], "name": "YheC/D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026841": {"description": "Inositolphosphotransferase Aur1/Ipt1", "go_ids": [], "go_terms": [], "name": "Aur1/Ipt1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026843": {"description": "Nuclease SbcCD subunit D, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SbcD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026845": {"description": "Neurexophilin/NXPE", "go_ids": [], "go_terms": [], "name": "NXPH/NXPE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026846": {"description": "E3 SUMO-protein ligase Nse2 (Mms21)", "go_ids": ["GO:0019789", "GO:0030915", "GO:0000724"], "go_terms": ["GO:0019789:SUMO transferase activity:F", "GO:0030915:Smc5-Smc6 complex:C", "GO:0000724:double-strand break repair via homologous recombination:P"], "name": "Nse2(Mms21)", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-SCE-3108214", "R-MMU-3108214", "R-SPO-3108214", "R-RNO-3108214", "R-HSA-3108214"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Family"}, "IPR026847": {"description": "Vacuolar protein sorting-associated protein 13", "go_ids": [], "go_terms": [], "name": "VPS13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026848": {"description": "E3 ubiquitin-protein ligase FANCL", "go_ids": ["GO:0004842", "GO:0043240", "GO:0036297"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F", "GO:0043240:Fanconi anaemia nuclear complex:C", "GO:0036297:interstrand cross-link repair:P"], "name": "Fancl", "pathway_ids": ["PWY-7511", "R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR026849": {"description": "Autophagy-related protein 2", "go_ids": ["GO:0006914"], "go_terms": ["GO:0006914:autophagy:P"], "name": "ATG2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026850": {"description": "FANCL C-terminal domain", "go_ids": [], "go_terms": [], "name": "FANCL_C", "pathway_ids": ["PWY-7511", "R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR026854": {"description": "Vacuolar protein sorting-associated protein 13, N-terminal domain", "go_ids": [], "go_terms": [], "name": "VPS13_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026856": {"description": "Sialidase family", "go_ids": ["GO:0004308"], "go_terms": ["GO:0004308:exo-alpha-sialidase activity:F"], "name": "Sialidase_fam", "pathway_ids": ["R-MMU-9840310", "R-BTA-9840310", "R-RNO-9840310", "R-SSC-6798695", "R-HSA-6798695", "R-SSC-4085001", "R-MMU-4085001", "R-HSA-9840310", "R-RNO-4085001", "R-HSA-4341670", "R-MMU-6798695", "R-BTA-6798695", "R-BTA-4085001", "R-HSA-4085001", "R-RNO-6798695", "R-SSC-9840310"], "pathways": ["R-MMU-9840310:r:Glycosphingolipid catabolism", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-4085001:r:Sialic acid metabolism", "R-MMU-4085001:r:Sialic acid metabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-RNO-4085001:r:Sialic acid metabolism", "R-HSA-4341670:r:Defective NEU1 causes sialidosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-4085001:r:Sialic acid metabolism", "R-HSA-4085001:r:Sialic acid metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-SSC-9840310:r:Glycosphingolipid catabolism"], "type": "Family"}, "IPR026858": {"description": "Vezatin", "go_ids": ["GO:0098609"], "go_terms": ["GO:0098609:cell-cell adhesion:P"], "name": "Vezatin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026859": {"description": "Myosin-binding domain", "go_ids": ["GO:0017022"], "go_terms": ["GO:0017022:myosin binding:F"], "name": "Myosin-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026864": {"description": "SH3b2-type SH3 domain", "go_ids": [], "go_terms": [], "name": "SH3b2-type_SH3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026866": {"description": "Protein CR006, P-loop domain", "go_ids": [], "go_terms": [], "name": "CR006_AAA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026869": {"description": "Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase EgtC-like", "go_ids": [], "go_terms": [], "name": "EgtC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026870": {"description": "Zinc-ribbon domain", "go_ids": [], "go_terms": [], "name": "Zinc_ribbon_dom", "pathway_ids": ["R-BTA-202670", "R-MMU-202670", "R-HSA-202670"], "pathways": ["R-BTA-202670:r:ERKs are inactivated", "R-MMU-202670:r:ERKs are inactivated", "R-HSA-202670:r:ERKs are inactivated"], "type": "Domain"}, "IPR026875": {"description": "Phosphohydrolase-associated domain", "go_ids": [], "go_terms": [], "name": "PHydrolase_assoc_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026876": {"description": "Fn3 associated repeat", "go_ids": [], "go_terms": [], "name": "Fn3_assoc_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR026877": {"description": "DXP reductoisomerase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DXPR_C", "pathway_ids": ["PWY-7560"], "pathways": ["PWY-7560:t:methylerythritol phosphate pathway II"], "type": "Domain"}, "IPR026881": {"description": "WYL domain", "go_ids": [], "go_terms": [], "name": "WYL_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026888": {"description": "Acetyl-CoA hydrolase/transferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AcetylCoA_hyd_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026889": {"description": "Transposase zinc-binding domain", "go_ids": [], "go_terms": [], "name": "Zn_Tnp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026890": {"description": "Mononegavirales mRNA-capping domain V", "go_ids": [], "go_terms": [], "name": "Mononeg_mRNAcap", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-9828721", "R-HSA-9833110", "R-HSA-9828806", "R-HSA-9820962", "R-HSA-9828642", "R-HSA-9834752", "R-HSA-9820960"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-9828642:r:Respiratory syncytial virus genome transcription", "R-HSA-9834752:r:Respiratory syncytial virus genome replication", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry"], "type": "Domain"}, "IPR026891": {"description": "Fibronectin type III-like domain", "go_ids": [], "go_terms": [], "name": "Fn3-like", "pathway_ids": ["PWY-3121", "PWY-6788", "PWY-7091", "PWY-7913", "PWY-7092", "PWY-5176", "PWY-6002"], "pathways": ["PWY-3121:t:linamarin degradation", "PWY-6788:t:cellulose degradation II (fungi)", "PWY-7091:t:linustatin bioactivation", "PWY-7913:t:firefly bioluminescence", "PWY-7092:t:neolinustatin bioactivation", "PWY-5176:t:coumarin biosynthesis (via 2-coumarate)", "PWY-6002:t:lotaustralin degradation"], "type": "Domain"}, "IPR026893": {"description": "Tyrosine/serine-protein phosphatase IphP-type", "go_ids": ["GO:0004721"], "go_terms": ["GO:0004721:phosphoprotein phosphatase activity:F"], "name": "Tyr/Ser_Pase_IphP-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026894": {"description": "DNAJ-containing protein, X-domain", "go_ids": [], "go_terms": [], "name": "DnaJ_X", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026895": {"description": "ER membrane protein complex subunit 1", "go_ids": ["GO:0072546"], "go_terms": ["GO:0072546:EMC complex:C"], "name": "EMC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026896": {"description": "Transcription termination and cleavage factor, C-terminal domain", "go_ids": ["GO:0031124"], "go_terms": ["GO:0031124:mRNA 3'-end processing:P"], "name": "CSTF_C", "pathway_ids": ["R-HSA-9770562", "R-MMU-9770562", "R-HSA-6784531", "R-MMU-77595", "R-HSA-73856", "R-MMU-73856", "R-BTA-73856", "R-HSA-72187", "R-HSA-77595", "R-SPO-9770562", "R-MMU-72187", "R-BTA-9770562", "R-HSA-9918481", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR026898": {"description": "Intramembrane metalloprotease PrsW", "go_ids": ["GO:0008233"], "go_terms": ["GO:0008233:peptidase activity:F"], "name": "PrsW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026899": {"description": "1,3-beta-glucan synthase component FKS1-like, domain-1", "go_ids": [], "go_terms": [], "name": "FKS1-like_dom1", "pathway_ids": ["PWY-6773"], "pathways": ["PWY-6773:t:1,3-beta-D-glucan biosynthesis"], "type": "Domain"}, "IPR026902": {"description": "RnfC Barrel sandwich hybrid domain", "go_ids": [], "go_terms": [], "name": "RnfC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026904": {"description": "tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, C-terminal", "go_ids": [], "go_terms": [], "name": "MnmG_C", "pathway_ids": ["R-HSA-6787450"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR026905": {"description": "Protein ASX-like, PHD domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "ASX-like_PHD", "pathway_ids": ["R-HSA-5689603", "R-MMU-5689603", "R-DME-5689603"], "pathways": ["R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases"], "type": "Domain"}, "IPR026906": {"description": "BspA-type LRR region", "go_ids": [], "go_terms": [], "name": "LRR_5", "pathway_ids": ["R-MMU-1679131", "R-HSA-375281", "R-DME-214874", "R-RNO-375281", "R-DME-214869", "R-DME-214862", "R-DME-214842", "R-HSA-418555", "R-DME-214844", "R-DME-214863", "R-CFA-375281", "R-MMU-375281", "R-HSA-5223345", "R-MMU-418555", "R-SSC-375281", "R-DME-209442"], "pathways": ["R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-375281:r:Hormone ligand-binding receptors", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-RNO-375281:r:Hormone ligand-binding receptors", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-418555:r:G alpha (s) signalling events", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-CFA-375281:r:Hormone ligand-binding receptors", "R-MMU-375281:r:Hormone ligand-binding receptors", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-MMU-418555:r:G alpha (s) signalling events", "R-SSC-375281:r:Hormone ligand-binding receptors", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'"], "type": "Repeat"}, "IPR026907": {"description": "Cyclin-D1-binding protein 1-like", "go_ids": [], "go_terms": [], "name": "GCIP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026910": {"description": "Shisa", "go_ids": [], "go_terms": [], "name": "Shisa", "pathway_ids": ["R-BTA-8957275", "R-MMU-381426", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-BTA-381426"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR026912": {"description": "Adenine deaminase C-terminal domain", "go_ids": [], "go_terms": [], "name": "Adenine_deam_C", "pathway_ids": ["PWY-6610"], "pathways": ["PWY-6610:t:adenine salvage"], "type": "Domain"}, "IPR026913": {"description": "Probable methyltransferase-like protein 24", "go_ids": [], "go_terms": [], "name": "METTL24", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR026919": {"description": "Adhesion G-protein coupled receptor V1", "go_ids": ["GO:0004930", "GO:0007194", "GO:0016020"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F", "GO:0007194:negative regulation of adenylate cyclase activity:P", "GO:0016020:membrane:C"], "name": "ADGRV1", "pathway_ids": ["R-HSA-9619665"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "type": "Family"}, "IPR026928": {"description": "FAX/IsoI-like", "go_ids": [], "go_terms": [], "name": "FAX/IsoI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026932": {"description": "Myelin gene regulatory factor, ICA domain", "go_ids": ["GO:0016540"], "go_terms": ["GO:0016540:protein autoprocessing:P"], "name": "MYRF_ICA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026935": {"description": "Butirosin biosynthesis protein H, N-terminal", "go_ids": [], "go_terms": [], "name": "BtrH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026937": {"description": "Strawberry notch, helicase C domain", "go_ids": [], "go_terms": [], "name": "SBNO_Helicase_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026939": {"description": "ZNF706-like superfamily", "go_ids": [], "go_terms": [], "name": "ZNF706-like_sf", "pathway_ids": ["R-MMU-212436", "R-HSA-212436", "R-GGA-212436"], "pathways": ["R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway", "R-GGA-212436:r:Generic Transcription Pathway"], "type": "Homologous_superfamily"}, "IPR026947": {"description": "Ubinuclein middle domain", "go_ids": [], "go_terms": [], "name": "UBN_middle_dom", "pathway_ids": ["R-MMU-2559584", "R-HSA-2559584"], "pathways": ["R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Domain"}, "IPR026950": {"description": "Capsule assembly protein Wzi", "go_ids": [], "go_terms": [], "name": "Caps_assemb_Wzi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026952": {"description": "WVELL protein", "go_ids": [], "go_terms": [], "name": "WVELL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026954": {"description": "PknH-like extracellular domain", "go_ids": [], "go_terms": [], "name": "PknH-like_Extracell", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026956": {"description": "D-serine dehydratase-like domain", "go_ids": [], "go_terms": [], "name": "D-ser_dehydrat-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026960": {"description": "Reverse transcriptase zinc-binding domain", "go_ids": [], "go_terms": [], "name": "RVT-Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026961": {"description": "PGG domain", "go_ids": [], "go_terms": [], "name": "PGG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026966": {"description": "Neurofascin/L1/NrCAM, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Neurofascin/L1/NrCAM_C", "pathway_ids": ["R-HSA-6798695", "R-RNO-445095", "R-DME-5673001", "R-MMU-210991", "R-HSA-445095", "R-DME-419037", "R-DME-1971475", "R-DME-375165", "R-RNO-373760", "R-DME-3000178", "R-HSA-373760", "R-DME-9913351", "R-HSA-447038", "R-HSA-210991", "R-DME-2024096", "R-HSA-447043", "R-MMU-437239", "R-RNO-210991", "R-RNO-437239", "R-RNO-445144", "R-RNO-447043", "R-HSA-437239", "R-MMU-445144", "R-MMU-447043", "R-HSA-447041", "R-DME-1474228", "R-DME-216083", "R-DME-445144", "R-DME-2022928", "R-MMU-445095", "R-DME-3000171", "R-HSA-445144", "R-MMU-6798695", "R-MMU-373760", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-MMU-210991:r:Basigin interactions", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-DME-419037:r:NCAM1 interactions", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-RNO-373760:r:L1CAM interactions", "R-DME-3000178:r:ECM proteoglycans", "R-HSA-373760:r:L1CAM interactions", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-447038:r:NrCAM interactions", "R-HSA-210991:r:Basigin interactions", "R-DME-2024096:r:HS-GAG degradation", "R-HSA-447043:r:Neurofascin interactions", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-210991:r:Basigin interactions", "R-RNO-437239:r:Recycling pathway of L1", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-447043:r:Neurofascin interactions", "R-HSA-437239:r:Recycling pathway of L1", "R-MMU-445144:r:Signal transduction by L1", "R-MMU-447043:r:Neurofascin interactions", "R-HSA-447041:r:CHL1 interactions", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-DME-216083:r:Integrin cell surface interactions", "R-DME-445144:r:Signal transduction by L1", "R-DME-2022928:r:HS-GAG biosynthesis", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-373760:r:L1CAM interactions", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR026968": {"description": "3-oxoadipate enol-lactonase 1/2", "go_ids": ["GO:0047570", "GO:0042952"], "go_terms": ["GO:0047570:3-oxoadipate enol-lactonase activity:F", "GO:0042952:beta-ketoadipate pathway:P"], "name": "PcaD/CatD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026971": {"description": "Condensin subunit 1/Condensin-2 complex subunit D3", "go_ids": ["GO:0007076"], "go_terms": ["GO:0007076:mitotic chromosome condensation:P"], "name": "CND1/NCAPD3", "pathway_ids": ["R-CEL-2299718", "R-HSA-2514853", "R-HSA-2299718", "R-SCE-2514853", "R-SPO-2514853", "R-MMU-2299718", "R-MMU-2514853"], "pathways": ["R-CEL-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes"], "type": "Family"}, "IPR026983": {"description": "Dynein heavy chain", "go_ids": ["GO:0030286", "GO:0045505", "GO:0051959", "GO:0007018"], "go_terms": ["GO:0030286:dynein complex:C", "GO:0045505:dynein intermediate chain binding:F", "GO:0051959:dynein light intermediate chain binding:F", "GO:0007018:microtubule-based movement:P"], "name": "DHC", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Family"}, "IPR026985": {"description": "Fanconi anemia-associated protein of 24kDa", "go_ids": ["GO:0036297", "GO:0043240"], "go_terms": ["GO:0036297:interstrand cross-link repair:P", "GO:0043240:Fanconi anaemia nuclear complex:C"], "name": "FAAP24", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-BTA-9833482", "R-BTA-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-BTA-9833482:r:PKR-mediated signaling", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR026987": {"description": "WD repeat-containing protein 18, C-terminal domain", "go_ids": [], "go_terms": [], "name": "WDR18_C", "pathway_ids": ["R-MMU-6791226", "R-DRE-6791226", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR026988": {"description": "YaaC-like protein", "go_ids": [], "go_terms": [], "name": "YaaC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026989": {"description": "Transposon-encoded protein TnpV", "go_ids": [], "go_terms": [], "name": "TnpV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026990": {"description": "Transposon-encoded protein TnpW", "go_ids": [], "go_terms": [], "name": "TnpW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026992": {"description": "Non-haem dioxygenase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DIOX_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR026995": {"description": "Astrotactin", "go_ids": ["GO:0001764"], "go_terms": ["GO:0001764:neuron migration:P"], "name": "Astrotactin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR026998": {"description": "Calpastatin", "go_ids": [], "go_terms": [], "name": "Calpastatin", "pathway_ids": ["R-HSA-1474228", "R-HSA-8862803", "R-SSC-1474228", "R-RNO-1474228", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Family"}, "IPR026999": {"description": "Alpha-s1 casein", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Alpha-s1_casein", "pathway_ids": ["R-HSA-5223345", "R-RNO-5223345", "R-MMU-5223345", "R-BTA-5223345"], "pathways": ["R-HSA-5223345:r:Miscellaneous transport and binding events", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-BTA-5223345:r:Miscellaneous transport and binding events"], "type": "Family"}, "IPR027005": {"description": "O-mannosyl-transferase-like", "go_ids": [], "go_terms": [], "name": "PMT-like", "pathway_ids": ["PWY-7922", "PWY-7921", "PWY-7979", "R-DRE-8932506", "R-MMU-8932505", "R-HSA-8932505", "R-DRE-9768727", "R-RNO-8932506", "R-HSA-8932504", "R-HSA-5083633", "R-RNO-8932504", "R-DME-8932506", "R-DRE-8932505", "R-DME-8932504", "R-DRE-8932504", "R-HSA-8932506", "R-DME-8932505", "R-HSA-9768727", "R-MMU-8932504", "R-HSA-5083629", "R-RNO-9768727", "R-MMU-9768727", "R-MMU-8932506", "R-RNO-8932505"], "pathways": ["PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-7979:t:protein O-mannosylation III (mammals, core M3)", "R-DRE-8932506:r:DAG1 core M1 glycosylations", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-8932506:r:DAG1 core M1 glycosylations", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-5083633:r:Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "R-RNO-8932504:r:DAG1 core M2 glycosylations", "R-DME-8932506:r:DAG1 core M1 glycosylations", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-DME-8932504:r:DAG1 core M2 glycosylations", "R-DRE-8932504:r:DAG1 core M2 glycosylations", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-DME-8932505:r:DAG1 core M3 glycosylations", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-HSA-5083629:r:Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-8932506:r:DAG1 core M1 glycosylations", "R-RNO-8932505:r:DAG1 core M3 glycosylations"], "type": "Family"}, "IPR027007": {"description": "C2 DOCK-type domain", "go_ids": [], "go_terms": [], "name": "C2_DOCK-type_domain", "pathway_ids": ["R-HSA-9013409", "R-HSA-6798695", "R-HSA-8875555", "R-MMU-8980692", "R-MMU-9013408", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-983231", "R-HSA-418885", "R-MMU-4420097", "R-HSA-8849471", "R-HSA-4420097", "R-HSA-9032759", "R-HSA-9013423", "R-HSA-9013148", "R-HSA-164944", "R-DRE-9013149", "R-HSA-9013408", "R-MMU-8849471", "R-HSA-9664422", "R-HSA-983231", "R-HSA-2029482", "R-MMU-2029482", "R-HSA-9013404", "R-DRE-983231", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-MMU-8875555", "R-HSA-8980692", "R-MMU-9032759", "R-MMU-6798695", "R-MMU-9013149", "R-MMU-418885"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-164944:r:Nef and signal transduction", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR027008": {"description": "Teashirt family", "go_ids": ["GO:0010468"], "go_terms": ["GO:0010468:regulation of gene expression:P"], "name": "Teashirt_fam", "pathway_ids": ["R-DME-390193"], "pathways": ["R-DME-390193:r:Transcriptional activation by YKI"], "type": "Family"}, "IPR027012": {"description": "Enkurin domain", "go_ids": [], "go_terms": [], "name": "Enkurin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027016": {"description": "Uncharacterised protein with YceI domain", "go_ids": [], "go_terms": [], "name": "UCP029811", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027017": {"description": "Uncharacterised peptidase with NlpC/P60 domain, YkfC type", "go_ids": [], "go_terms": [], "name": "P60_peptidase_YkfC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027018": {"description": "Hemolysin E", "go_ids": ["GO:0044179"], "go_terms": ["GO:0044179:hemolysis in another organism:P"], "name": "Hemolysin_E", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR027020": {"description": "Protein YnjB", "go_ids": [], "go_terms": [], "name": "YnjB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027021": {"description": "Cyclic di-GMP binding protein, PA4608 type", "go_ids": [], "go_terms": [], "name": "C-di-GMP_BP_PA4608", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027022": {"description": "ABC transporter permease protein, BceB-type", "go_ids": ["GO:0055085"], "go_terms": ["GO:0055085:transmembrane transport:P"], "name": "ABC_permease_BceB-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027023": {"description": "Putative lipopolysaccharide kinase InaA", "go_ids": [], "go_terms": [], "name": "Put_LipoPS_kinase_InaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027024": {"description": "ABC-type uncharacterised transport system, substrate-binding component, TM0202 type", "go_ids": [], "go_terms": [], "name": "UCP027386_ABC_sbc_TM0202", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027027": {"description": "GOSR2/Membrin/Bos1", "go_ids": ["GO:0016192", "GO:0005484", "GO:0005794"], "go_terms": ["GO:0016192:vesicle-mediated transport:P", "GO:0005484:SNAP receptor activity:F", "GO:0005794:Golgi apparatus:C"], "name": "GOSR2/Membrin/Bos1", "pathway_ids": ["R-SPO-6807878", "R-MMU-204005", "R-HSA-381038", "R-SCE-6811440", "R-RNO-5694530", "R-HSA-6811438", "R-MMU-6811438", "R-SCE-6807878", "R-CEL-5694530", "R-RNO-6807878", "R-RNO-6811440", "R-MMU-5694530", "R-RNO-6811438", "R-HSA-6807878", "R-SCE-204005", "R-CEL-6807878", "R-SPO-204005", "R-SCE-114608", "R-SPO-5694530", "R-MMU-6807878", "R-HSA-6811440", "R-DME-6811438", "R-HSA-5694530", "R-RNO-204005", "R-MMU-6811440", "R-RNO-114608", "R-HSA-204005", "R-SCE-5694530", "R-CEL-204005", "R-CEL-6811438", "R-DME-6807878", "R-DME-5694530", "R-DME-204005"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-CEL-5694530:r:Cargo concentration in the ER", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-5694530:r:Cargo concentration in the ER", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SCE-114608:r:Platelet degranulation", "R-SPO-5694530:r:Cargo concentration in the ER", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-114608:r:Platelet degranulation", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-SCE-5694530:r:Cargo concentration in the ER", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-DME-5694530:r:Cargo concentration in the ER", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Family"}, "IPR027031": {"description": "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2", "go_ids": [], "go_terms": [], "name": "Gly-tRNA_synthase/POLG2", "pathway_ids": ["R-DME-9913635", "R-HSA-379726", "R-MMU-9913635", "R-HSA-2151201", "R-HSA-379716", "R-BTA-9913635", "R-HSA-9913635"], "pathways": ["R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-BTA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Family"}, "IPR027032": {"description": "Twinkle-like protein", "go_ids": ["GO:0043139", "GO:0003697"], "go_terms": ["GO:0043139:5'-3' DNA helicase activity:F", "GO:0003697:single-stranded DNA binding:F"], "name": "Twinkle-like", "pathway_ids": ["R-DME-9913635", "R-HSA-9837999", "R-MMU-9837999", "R-HSA-2151201", "R-MMU-9913635", "R-DME-9837999", "R-HSA-9913635"], "pathways": ["R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Family"}, "IPR027033": {"description": "Cytidine monophosphate-N-acetylneuraminic acid hydroxylase", "go_ids": [], "go_terms": [], "name": "Cnh", "pathway_ids": ["PWY-6144"], "pathways": ["PWY-6144:t:CMP-N-glycoloylneuraminate biosynthesis"], "type": "Family"}, "IPR027038": {"description": "Ran GTPase-activating protein", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "RanGap", "pathway_ids": ["R-SCE-9615933", "R-MMU-2500257", "R-SPO-9793242", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-MMU-2467813", "R-HSA-141444", "R-SPO-9615933", "R-MMU-68877", "R-HSA-9648025", "R-SCE-9793242", "R-CEL-9615933", "R-MMU-4615885", "R-MMU-9615933", "R-DME-9615933", "R-CEL-9793242", "R-HSA-9615933", "R-HSA-68877", "R-HSA-165054", "R-HSA-9793242", "R-DME-4615885", "R-HSA-5663220", "R-HSA-4615885", "R-MMU-9648025", "R-MMU-9793242", "R-MMU-5663220"], "pathways": ["R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-9793242:r:SUMOylation of nuclear envelope proteins", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-9793242:r:SUMOylation of nuclear envelope proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-9793242:r:SUMOylation of nuclear envelope proteins", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR027039": {"description": "Cartilage acidic protein 1", "go_ids": [], "go_terms": [], "name": "Crtac1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027040": {"description": "26S proteasome non-ATPase regulatory subunit 4", "go_ids": [], "go_terms": [], "name": "PSMD4", "pathway_ids": ["R-SCE-9907900", "R-MMU-9907900", "R-HSA-9907900", "R-DME-209360", "R-DME-432524", "R-DME-9907900", "R-DME-432395", "R-DDI-9907900", "R-DME-209461", "R-DME-216167", "R-CEL-9907900", "R-DME-432626", "R-DME-209406", "R-DME-538864"], "pathways": ["R-SCE-9907900:r:Proteasome assembly", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-9907900:r:Proteasome assembly", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DME-432524:r:Degradation of PER", "R-DME-9907900:r:Proteasome assembly", "R-DME-432395:r:Degradation of TIM", "R-DDI-9907900:r:Proteasome assembly", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DME-216167:r:Nuclear CI is degraded", "R-CEL-9907900:r:Proteasome assembly", "R-DME-432626:r:Circadian Clock pathway", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-538864:r:Degradation of CRY"], "type": "Family"}, "IPR027051": {"description": "XdhC Rossmann domain", "go_ids": [], "go_terms": [], "name": "XdhC_Rossmann_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027054": {"description": "Mannosyltransferase ALG2", "go_ids": ["GO:0009101", "GO:0004378"], "go_terms": ["GO:0009101:glycoprotein biosynthetic process:P", "GO:0004378:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity:F"], "name": "ALG2", "pathway_ids": ["R-SCE-446193", "R-MMU-446193", "R-HSA-4549349", "R-SPO-446193", "R-HSA-446193", "R-DDI-446193"], "pathways": ["R-SCE-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-4549349:r:Defective ALG2 causes CDG-1i", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DDI-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Family"}, "IPR027056": {"description": "Gluconate 2-dehydrogenase subunit 3", "go_ids": [], "go_terms": [], "name": "Gluconate_2DH_su3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027057": {"description": "CAAX prenyl protease 1", "go_ids": ["GO:0071586", "GO:0008233"], "go_terms": ["GO:0071586:CAAX-box protein processing:P", "GO:0008233:peptidase activity:F"], "name": "CAXX_Prtase_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027059": {"description": "Coatomer delta subunit", "go_ids": ["GO:0006890", "GO:0030126"], "go_terms": ["GO:0006890:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum:P", "GO:0030126:COPI vesicle coat:C"], "name": "Coatomer_dsu", "pathway_ids": ["R-BTA-6807878", "R-HSA-6811434", "R-SCE-6807878", "R-RNO-6811434", "R-SCE-6811434", "R-DDI-6807878", "R-RNO-6807878", "R-GGA-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-DDI-6811434", "R-MMU-6811434", "R-BTA-6811434", "R-GGA-6811434", "R-CEL-6811434"], "pathways": ["R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR027065": {"description": "Lon protease", "go_ids": ["GO:0004252", "GO:0004176", "GO:0005524", "GO:0030163"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0004176:ATP-dependent peptidase activity:F", "GO:0005524:ATP binding:F", "GO:0030163:protein catabolic process:P"], "name": "Lon_Prtase", "pathway_ids": ["R-BTA-9033241", "R-DDI-9837999", "R-RNO-9033241", "R-MMU-9837999", "R-CEL-9837999", "R-HSA-390471", "R-SPO-9837999", "R-SCE-9837999", "R-DME-9837999", "R-HSA-9841251", "R-HSA-9837999", "R-MMU-9033241", "R-RNO-9837999", "R-HSA-9033241"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR027073": {"description": "5'-3' exoribonuclease", "go_ids": [], "go_terms": [], "name": "5_3_exoribonuclease", "pathway_ids": ["R-MMU-450385", "R-MMU-6791226", "R-HSA-450385", "R-HSA-9930044", "R-MMU-450513", "R-HSA-9770562", "R-HSA-390471", "R-HSA-6791226", "R-HSA-450513", "R-SCE-450513", "R-GGA-6791226", "R-HSA-9918487", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-GGA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Family"}, "IPR027074": {"description": "Integrator complex subunit 9", "go_ids": ["GO:0032039", "GO:0016180"], "go_terms": ["GO:0032039:integrator complex:C", "GO:0016180:snRNA processing:P"], "name": "Integrator_9su", "pathway_ids": ["R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505", "R-DDI-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR027075": {"description": "Cleavage and polyadenylation specificity factor subunit 2", "go_ids": ["GO:0006398", "GO:0003723", "GO:0005847"], "go_terms": ["GO:0006398:mRNA 3'-end processing by stem-loop binding and cleavage:P", "GO:0003723:RNA binding:F", "GO:0005847:mRNA cleavage and polyadenylation specificity factor complex:C"], "name": "CPSF2", "pathway_ids": ["R-CEL-159231", "R-HSA-9770562", "R-DME-77595", "R-MMU-9770562", "R-SPO-159231", "R-SCE-77595", "R-MMU-77595", "R-MMU-73856", "R-BTA-73856", "R-HSA-73856", "R-DDI-9770562", "R-CEL-73856", "R-HSA-72187", "R-DME-159231", "R-SPO-77595", "R-CEL-77595", "R-HSA-159231", "R-HSA-77595", "R-SPO-9770562", "R-DME-9770562", "R-MMU-72187", "R-DDI-77595", "R-CEL-9770562", "R-BTA-9770562", "R-BTA-159231", "R-DME-73856", "R-HSA-9918481", "R-MMU-159231", "R-BTA-77595"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Family"}, "IPR027078": {"description": "Small nuclear ribonucleoprotein E", "go_ids": ["GO:0005681", "GO:0000398"], "go_terms": ["GO:0005681:spliceosomal complex:C", "GO:0000398:mRNA splicing, via spliceosome:P"], "name": "snRNP-E", "pathway_ids": ["R-CEL-111367", "R-HSA-191859", "R-MMU-77588", "R-CEL-72165", "R-MMU-9770562", "R-GGA-73856", "R-CEL-191859", "R-HSA-73856", "R-DME-72163", "R-CEL-73856", "R-DRE-191859", "R-DRE-72163", "R-DME-9770562", "R-GGA-72163", "R-DRE-9770562", "R-DME-111367", "R-CEL-9770562", "R-HSA-77588", "R-HSA-111367", "R-HSA-72165", "R-GGA-9770562", "R-DME-73856", "R-CEL-72163", "R-HSA-9918481", "R-MMU-191859", "R-GGA-72165", "R-HSA-9770562", "R-MMU-72163", "R-MMU-73856", "R-HSA-9754678", "R-GGA-111367", "R-HSA-72163", "R-SPO-9770562", "R-DME-72165", "R-MMU-72165", "R-MMU-111367", "R-DME-77588", "R-SPO-72163", "R-GGA-191859", "R-CEL-77588", "R-DRE-72165", "R-GGA-77588"], "pathways": ["R-CEL-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-191859:r:snRNP Assembly", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-191859:r:snRNP Assembly", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-191859:r:snRNP Assembly", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-DME-9770562:r:mRNA Polyadenylation", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-9770562:r:mRNA Polyadenylation", "R-DME-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-GGA-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-191859:r:snRNP Assembly", "R-GGA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-GGA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-GGA-191859:r:snRNP Assembly", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-GGA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "type": "Family"}, "IPR027079": {"description": "TFIIH subunit Tfb1/GTF2H1", "go_ids": ["GO:0000439", "GO:0006289", "GO:0006351"], "go_terms": ["GO:0000439:transcription factor TFIIH core complex:C", "GO:0006289:nucleotide-excision repair:P", "GO:0006351:DNA-templated transcription:P"], "name": "Tfb1/GTF2H1", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DME-6781823", "R-DME-76042", "R-MMU-113418", "R-HSA-427413", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-SPO-5696395", "R-SPO-76042", "R-HSA-167246", "R-HSA-73776", "R-MMU-5696395", "R-DME-72086", "R-DDI-674695", "R-HSA-75953", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-DME-75953", "R-MMU-73779", "R-DME-6782135", "R-MMU-76042", "R-SPO-75953", "R-SPO-113418", "R-DDI-73779", "R-DME-674695", "R-DDI-6781823", "R-DDI-72086", "R-MMU-674695", "R-SCE-76042", "R-HSA-167161", "R-DME-112382", "R-HSA-167200", "R-SCE-674695", "R-HSA-5696395", "R-HSA-167160", "R-DDI-77075", "R-SPO-73779", "R-DDI-113418", "R-MMU-73772", "R-MMU-72086", "R-MMU-6782210", "R-SPO-73776", "R-DME-73772", "R-SCE-73776", "R-SCE-6782135", "R-DDI-6782135", "R-MMU-73762", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-DME-6796648", "R-HSA-72086", "R-DME-77075", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-MMU-6781823", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-SCE-6782210", "R-HSA-167172", "R-MMU-5696400", "R-SCE-6796648", "R-SCE-73779", "R-DME-113418", "R-SPO-77075", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-SCE-6781823", "R-MMU-73863", "R-HSA-6782135", "R-DME-5696395", "R-HSA-73762", "R-HSA-73863", "R-SPO-73772", "R-SPO-5696400", "R-HSA-75955", "R-SCE-77075", "R-SPO-6782210", "R-DME-5696400", "R-MMU-77075", "R-HSA-5696400", "R-DME-6782210", "R-HSA-76042", "R-SPO-6782135", "R-HSA-674695", 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"R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-RNO-73776", "R-SPO-5696395", "R-SPO-76042", "R-HSA-167246", "R-HSA-73776", "R-HSA-69656", "R-MMU-5696395", "R-HSA-75953", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-RNO-6782210", "R-SPO-113418", "R-RNO-76042", "R-RNO-5696395", "R-RNO-73762", "R-MMU-674695", "R-RNO-8939236", "R-SCE-76042", "R-HSA-167161", "R-SPO-69202", "R-MMU-69656", "R-HSA-167200", "R-RNO-112382", "R-SCE-674695", "R-HSA-167160", "R-HSA-5696395", "R-SPO-73779", "R-MMU-73772", "R-MMU-6782210", "R-MMU-72086", "R-MMU-69273", "R-SPO-73776", "R-RNO-75953", "R-SCE-6782135", "R-SCE-73776", "R-MMU-69231", "R-MMU-73762", "R-HSA-6781827", "R-MMU-6782135", "R-HSA-72086", "R-HSA-167162", "R-MMU-8939236", "R-MMU-69202", "R-MMU-6781823", "R-SPO-69656", "R-HSA-167152", "R-HSA-113418", "R-HSA-6782210", "R-RNO-69656", "R-MMU-73776", "R-SCE-6782210", "R-HSA-167172", "R-SCE-6796648", "R-SCE-73779", 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"R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR027093": {"description": "EAF family", "go_ids": ["GO:0006368", "GO:0032783"], "go_terms": ["GO:0006368:transcription elongation by RNA polymerase II:P", "GO:0032783:super elongation complex:C"], "name": "EAF_fam", "pathway_ids": ["R-DME-112382", "R-RNO-112382", "R-RNO-674695", "R-DME-674695", "R-HSA-75955", "R-RNO-75955", "R-MMU-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-HSA-112382", "R-MMU-112382"], "pathways": ["R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-112382:r:Formation of RNA Pol II 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"R-HSA-9013419", "R-CEL-5205685", "R-MMU-5205685", "R-MMU-9013419"], "pathways": ["R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-9013419:r:RHOT2 GTPase cycle"], "type": "Family"}, "IPR027095": {"description": "Golgin-45", "go_ids": ["GO:0043001", "GO:0007030"], "go_terms": ["GO:0043001:Golgi to plasma membrane protein transport:P", "GO:0007030:Golgi organization:P"], "name": "Golgin-45", "pathway_ids": ["R-RNO-162658", "R-MMU-162658", "R-HSA-162658"], "pathways": ["R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization"], "type": "Family"}, "IPR027098": {"description": "Sodium channel subunit beta-1/beta-3", "go_ids": ["GO:0017080", "GO:0001518", "GO:0006814"], "go_terms": ["GO:0017080:sodium channel regulator activity:F", "GO:0001518:voltage-gated sodium channel complex:C", "GO:0006814:sodium ion transport:P"], "name": "Na_channel_b1/b3", "pathway_ids": ["R-HSA-9717207", "R-HSA-445095", "R-HSA-5576892", "R-BTA-5576892"], "pathways": ["R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-BTA-5576892:r:Phase 0 - rapid depolarisation"], "type": "Family"}, "IPR027104": {"description": "U4/U6 small nuclear ribonucleoprotein Prp3", "go_ids": ["GO:0046540", "GO:0000398"], "go_terms": ["GO:0046540:U4/U6 x U5 tri-snRNP complex:C", "GO:0000398:mRNA splicing, via spliceosome:P"], "name": "Prp3", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR027105": {"description": "U4/U6 small nuclear ribonucleoprotein Prp31", "go_ids": ["GO:0000244", "GO:0046540", "GO:0000398"], "go_terms": ["GO:0000244:spliceosomal tri-snRNP complex assembly:P", "GO:0046540:U4/U6 x U5 tri-snRNP complex:C", "GO:0000398:mRNA splicing, via spliceosome:P"], "name": "Prp31", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR027107": {"description": "Tuberin/Ral GTPase-activating protein subunit alpha", "go_ids": ["GO:0005096", "GO:0043547", "GO:0005634"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0043547:positive regulation of GTPase activity:P", "GO:0005634:nucleus:C"], "name": "Tuberin/Ral-act_asu", "pathway_ids": ["R-RNO-8854214", "R-MMU-9013407", "R-HSA-8854214", "R-MMU-380972", "R-HSA-5674400", "R-MMU-198323", "R-SPO-5628897", "R-MMU-1632852", "R-RNO-9013407", "R-RNO-5628897", "R-SPO-380972", "R-RNO-165181", "R-SPO-165181", "R-HSA-5628897", "R-MMU-8854214", "R-SPO-198323", "R-HSA-198323", "R-RNO-1632852", "R-MMU-165181", "R-RNO-380972", "R-HSA-1445148", "R-HSA-1632852", "R-MMU-5628897", "R-RNO-198323", "R-HSA-165181", "R-HSA-380972", "R-HSA-9013407", "R-DME-9013407"], "pathways": ["R-RNO-8854214:r:TBC/RABGAPs", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-380972:r:Energy dependent 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"R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-DRE-1433559:r:Regulation of KIT signaling", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-GGA-1433559:r:Regulation of KIT signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", 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"R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9648002:r:RAS processing", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Family"}, "IPR027266": {"description": "Aminomethyltransferase superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "TrmE/GcvT-like", "pathway_ids": ["R-MMU-204174", "R-HSA-6798163", "R-HSA-204174", "R-MMU-6783984", "R-RNO-6798163", "R-BTA-6783984", "R-SCE-6783984", "R-HSA-6783984", "R-DDI-6783984", "R-MMU-6798163", "R-SPO-6783984", "R-HSA-6787450", "R-CFA-6783984"], "pathways": ["R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-6798163:r:Choline catabolism", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-6783984:r:Glycine degradation", "R-RNO-6798163:r:Choline catabolism", "R-BTA-6783984:r:Glycine degradation", "R-SCE-6783984:r:Glycine degradation", "R-HSA-6783984:r:Glycine degradation", "R-DDI-6783984:r:Glycine 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"R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-GGA-9013409:r:RHOJ GTPase cycle", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-437239:r:Recycling pathway of L1", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-9035034:r:RHOF GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-9013424:r:RHOV GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6794361:r:Neurexins and neuroligins", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-844456:r:The NLRP3 inflammasome", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-SCE-9013424:r:RHOV GTPase cycle", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-6807004:r:Negative regulation of MET activity", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-HSA-193648:r:NRAGE signals death through JNK", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-6807004:r:Negative regulation of MET activity", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-SPO-9035034:r:RHOF GTPase cycle", "R-MMU-844456:r:The NLRP3 inflammasome", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-182971:r:EGFR downregulation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR027268": {"description": "Peptidase M4/M1, CTD superfamily", "go_ids": [], "go_terms": [], "name": "Peptidase_M4/M1_CTD_sf", "pathway_ids": ["R-SSC-2022377", "R-HSA-6798695", "R-HSA-2142691", "R-SPO-2142691", "R-CEL-73779", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DRE-73779", "R-HSA-9018676", "R-SCE-9020265", "R-CEL-6798695", "R-RNO-9023661", "R-DME-76042", "R-MMU-6804756", "R-BTA-6798695", "R-SCE-9018896", "R-DRE-75953", "R-CEL-9020265", "R-CEL-9018681", "R-CEL-9023661", "R-SPO-76042", "R-SPO-9018896", "R-HSA-73776", "R-DDI-9020265", "R-HSA-9023661", "R-HSA-75953", "R-HSA-9018896", "R-SCE-2142691", "R-CEL-75953", "R-DME-75953", "R-MMU-73779", "R-CEL-73776", "R-MMU-76042", "R-RNO-9018676", "R-SPO-75953", "R-MMU-2022377", "R-MMU-9018676", "R-CEL-76042", "R-DDI-6798695", "R-DRE-6804756", "R-BTA-9018896", "R-DME-674695", "R-RNO-1236977", "R-BTA-2142691", "R-SPO-9020265", "R-MMU-1236977", "R-HSA-2022377", "R-MMU-674695", "R-SCE-76042", "R-DME-6804756", "R-HSA-167161", "R-CEL-674695", "R-DDI-9018896", "R-HSA-6804756", "R-CEL-9018896", "R-HSA-1445148", "R-SCE-674695", "R-MMU-983170", "R-MMU-2142691", "R-MMU-6798695", "R-SPO-73779", "R-DDI-9018676", "R-RNO-983168", "R-SPO-73776", "R-RNO-9018896", "R-RNO-6798695", "R-SCE-73776", "R-MMU-9018896", "R-BTA-9018681", "R-SPO-6798695", "R-RNO-983170", "R-HSA-9018681", "R-MMU-9018681", "R-CEL-983170", "R-SCE-6798695", "R-DME-73779", "R-SPO-9018681", "R-CEL-2142691", "R-CEL-983168", "R-MMU-9023661", "R-HSA-167162", "R-BTA-9020265", "R-DME-73776", "R-SCE-9023661", "R-DDI-2142691", "R-SPO-983168", "R-MMU-73776", "R-SCE-983168", "R-SCE-9018676", "R-HSA-167172", "R-BTA-9023661", "R-SCE-983170", "R-CEL-9018676", "R-SCE-73779", "R-DRE-76042", "R-HSA-9020265", "R-DDI-9018681", "R-RNO-2022377", "R-DRE-73776", "R-SPO-9018676", "R-HSA-983168", "R-HSA-1236977", "R-BTA-983170", "R-DDI-9023661", "R-HSA-983170", "R-RNO-2142691", "R-DRE-674695", "R-SPO-9023661", "R-MMU-9020265", "R-MMU-983168", "R-RNO-9018681", "R-HSA-674695", "R-CFA-6798695", "R-SCE-9018681", "R-HSA-76042", "R-BTA-9018676", "R-RNO-9020265", "R-HSA-73779"], "pathways": ["R-SSC-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", 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Angiotensinogen to Angiotensins", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6798695:r:Neutrophil degranulation", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-1236977:r:Endosomal/Vacuolar pathway", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II 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"R-SCE-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-DDI-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9018676:r:Biosynthesis of D-series resolvins", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-9018676:r:Biosynthesis of D-series resolvins", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-DDI-9018681:r:Biosynthesis of protectins", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", 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protectins", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Homologous_superfamily"}, "IPR027271": {"description": "Acetolactate synthase/Transcription factor NikR, C-terminal", "go_ids": [], "go_terms": [], "name": "Acetolactate_synth/TF_NikR_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027272": {"description": "Piezo family", "go_ids": ["GO:0016020", "GO:0008381"], "go_terms": ["GO:0016020:membrane:C", "GO:0008381:mechanosensitive monoatomic ion channel activity:F"], "name": "Piezo", "pathway_ids": ["R-HSA-9860927", "R-HSA-9856532", "R-HSA-9856530"], "pathways": ["R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Family"}, "IPR027273": {"description": "Neocarzinostatin-like superfamily", "go_ids": [], "go_terms": [], "name": "Neocarzinostatin-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027274": {"description": "Protein kinase C, epsilon", "go_ids": ["GO:0004699"], "go_terms": ["GO:0004699:diacylglycerol-dependent, calcium-independent serine/threonine kinase activity:F"], "name": "PKC_epsilon", "pathway_ids": ["R-MMU-114508", "R-HSA-114508", "R-RNO-2029485", "R-HSA-418597", "R-MMU-2029485", "R-MMU-1250196", "R-RNO-1250196", "R-HSA-2029485", "R-RNO-114508", "R-HSA-1250196", "R-HSA-1489509", "R-MMU-1489509", "R-RNO-1489509"], "pathways": ["R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-418597:r:G alpha (z) signalling events", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-1489509:r:DAG and IP3 signaling", "R-RNO-1489509:r:DAG and IP3 signaling"], "type": "Family"}, "IPR027275": {"description": "PRC-barrel domain", "go_ids": [], "go_terms": [], "name": "PRC-brl_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027276": {"description": "Transforming protein C-ets-2", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "Transform_prot_C-ets-2", "pathway_ids": ["R-MMU-2559585", "R-BTA-2559585", "R-GGA-2559585", "R-HSA-2559585"], "pathways": ["R-MMU-2559585:r:Oncogene Induced Senescence", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-GGA-2559585:r:Oncogene Induced Senescence", "R-HSA-2559585:r:Oncogene Induced Senescence"], "type": "Family"}, "IPR027277": {"description": "Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD", "go_ids": [], "go_terms": [], "name": "NadC/ModD", "pathway_ids": ["PWY-7342", "PWY-8277", "PWY-5653", "PWY-5316", "PWY-8352", "R-MMU-196807", "R-HSA-196807", "R-DDI-196807", "R-RNO-196807", "R-SSC-196807", "R-SCE-196807"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-8277:t:NAD de novo biosynthesis IV (anaerobic)", "PWY-5653:t:NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde", "PWY-5316:t:nicotine biosynthesis", "PWY-8352:t:NAD de novo biosynthesis III", "R-MMU-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-SSC-196807:r:Nicotinate metabolism", "R-SCE-196807:r:Nicotinate metabolism"], "type": "Family"}, "IPR027278": {"description": "1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase", "go_ids": [], "go_terms": [], "name": "ACCD_DCysDesulf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027279": {"description": "D-aminopeptidase/lipoprotein domain superfamily", "go_ids": [], "go_terms": [], "name": "D_amino_pept/lipop_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027281": {"description": "Saccharopine dehydrogenase [NAD(+), L-lysine-forming]", "go_ids": ["GO:0009085", "GO:0004754"], "go_terms": ["GO:0009085:L-lysine biosynthetic process:P", "GO:0004754:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity:F"], "name": "Lys1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027282": {"description": "Two partner secretion pathway transporter", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein 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"R-BTA-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-418346:r:Platelet homeostasis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Homologous_superfamily"}, "IPR027312": {"description": "Sda1", "go_ids": ["GO:0042273", "GO:0000055"], "go_terms": ["GO:0042273:ribosomal large subunit biogenesis:P", "GO:0000055:ribosomal large subunit export from nucleus:P"], "name": "Sda1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027324": {"description": "Microtubule associated protein MAP2/MAP4/Tau", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "MAP2/MAP4/Tau", "pathway_ids": ["R-RNO-9833482", "R-RNO-264870", "R-MMU-9833482", "R-HSA-264870", "R-HSA-9619483", "R-HSA-9833482", "R-MMU-264870"], "pathways": ["R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins"], "type": "Family"}, "IPR027328": {"description": "Microtubule-associated protein RP/EB", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "MAPRE", "pathway_ids": ["R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-MMU-8852276", "R-XTR-2467813", "R-HSA-9918485", "R-HSA-380284", "R-XTR-380270", "R-BTA-5663220", "R-MMU-68877", "R-RNO-5620912", "R-XTR-8854518", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-BTA-380259", "R-RNO-380320", "R-HSA-2565942", "R-XTR-141444", "R-HSA-380320", "R-XTR-5620912", "R-BTA-2467813", "R-RNO-2565942", "R-BTA-2565942", "R-HSA-68877", "R-BTA-5620912", "R-RNO-380284", "R-BTA-2500257", "R-BTA-380320", "R-RNO-8852276", "R-MMU-5620912", "R-HSA-5620912", "R-MMU-9648025", "R-BTA-380284", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-HSA-2500257", "R-MMU-141444", "R-MMU-380259", "R-RNO-8854518", "R-HSA-8852276", "R-HSA-141444", "R-MMU-380270", "R-XTR-5663220", "R-XTR-380284", "R-HSA-9648025", "R-HSA-380270", "R-XTR-68877", "R-RNO-5663220", "R-XTR-380259", "R-XTR-8852276", "R-XTR-380320", "R-RNO-380259", "R-BTA-380270", "R-BTA-8854518", "R-XTR-2565942", "R-MMU-8854518", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-BTA-9648025", "R-HSA-380259", "R-BTA-141444", "R-XTR-2500257", "R-RNO-380270", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR027329": {"description": "TPX2, C-terminal", "go_ids": [], "go_terms": [], "name": "TPX2_C", "pathway_ids": ["R-MMU-8854518", "R-MMU-6804756", "R-HSA-6804756", "R-XTR-6804756", "R-HSA-8854518", "R-XTR-8854518"], "pathways": ["R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-XTR-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-XTR-8854518:r:AURKA Activation by TPX2"], "type": "Domain"}, "IPR027330": {"description": "TPX2 central domain", "go_ids": [], "go_terms": [], "name": "TPX2_central_dom", "pathway_ids": ["R-MMU-8854518", "R-MMU-6804756", "R-HSA-6804756", "R-XTR-6804756", "R-HSA-8854518", "R-XTR-8854518"], "pathways": ["R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-XTR-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-XTR-8854518:r:AURKA Activation by TPX2"], "type": "Domain"}, "IPR027351": {"description": "(+) RNA virus helicase core domain", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "(+)RNA_virus_helicase_core_dom", "pathway_ids": ["R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-191859", "R-HSA-9705671", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR027353": {"description": "NET domain", "go_ids": [], "go_terms": [], "name": "NET_dom", "pathway_ids": ["R-HSA-9909649", "R-HSA-9679191", "R-DME-8951936", "R-DME-9909649", "R-HSA-8951936"], "pathways": ["R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-8951936:r:RUNX3 regulates p14-ARF", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-8951936:r:RUNX3 regulates p14-ARF"], "type": "Domain"}, "IPR027354": {"description": "YcgL domain", "go_ids": [], "go_terms": [], "name": "YcgL_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027356": {"description": "NPH3 domain", "go_ids": [], "go_terms": [], "name": "NPH3_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027359": {"description": "Voltage-dependent channel domain superfamily", "go_ids": [], "go_terms": [], "name": "Volt_channel_dom_sf", "pathway_ids": ["R-HSA-6798695", "R-MMU-1222556", "R-DME-1296072", "R-DME-422356", "R-RNO-5576894", "R-CEL-5576890", "R-RNO-112308", "R-HSA-9856532", "R-MMU-381676", "R-XTR-1222556", "R-XTR-1300642", "R-HSA-5576893", "R-MMU-5576893", "R-HSA-9662360", "R-DRE-6798695", "R-PFA-5576890", "R-DME-5576892", "R-RNO-5576892", "R-MMU-1300642", "R-MMU-5620916", "R-BTA-5576894", "R-HSA-400042", "R-DRE-1300642", "R-DME-5576890", "R-XTR-6798695", "R-PFA-381676", "R-HSA-419037", "R-GGA-1296072", "R-HSA-381676", "R-MMU-6798695", "R-HSA-112308", "R-RNO-5576890", "R-HSA-5576890", "R-MMU-5576890", "R-DME-5576893", "R-RNO-1300642", "R-RNO-5576893", "R-GGA-422356", "R-BTA-1296072", "R-BTA-5620916", "R-SPO-445355", "R-HSA-445095", "R-MMU-422356", "R-HSA-1300642", "R-MMU-5576892", "R-HSA-2672351", "R-DME-5576894", "R-HSA-5576892", "R-HSA-5620916", "R-RNO-2672351", "R-HSA-1222556", "R-MMU-2672351", "R-DRE-1222556", "R-DRE-2672351", "R-DME-381676", "R-MMU-112308", "R-MMU-1296072", "R-MMU-5576894", "R-HSA-445355", "R-CEL-1300642", "R-RNO-1296072", "R-RNO-381676", "R-GGA-381676", "R-CEL-381676", "R-HSA-1660514", "R-HSA-9717207", "R-RNO-422356", "R-HSA-1296072", "R-HSA-5576894", "R-SCE-445355", "R-HSA-422356"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DME-1296072:r:Voltage gated Potassium channels", "R-DME-422356:r:Regulation of insulin secretion", "R-RNO-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-CEL-5576890:r:Phase 3 - rapid repolarisation", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-XTR-1222556:r:ROS and RNS production in phagocytes", "R-XTR-1300642:r:Sperm Motility And Taxes", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DRE-6798695:r:Neutrophil degranulation", "R-PFA-5576890:r:Phase 3 - rapid repolarisation", "R-DME-5576892:r:Phase 0 - rapid depolarisation", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-MMU-1300642:r:Sperm Motility And Taxes", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-DRE-1300642:r:Sperm Motility And Taxes", "R-DME-5576890:r:Phase 3 - rapid repolarisation", "R-XTR-6798695:r:Neutrophil degranulation", "R-PFA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-419037:r:NCAM1 interactions", "R-GGA-1296072:r:Voltage gated Potassium channels", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-RNO-5576890:r:Phase 3 - rapid repolarisation", "R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-DME-5576893:r:Phase 2 - plateau phase", "R-RNO-1300642:r:Sperm Motility And Taxes", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-GGA-422356:r:Regulation of insulin secretion", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-SPO-445355:r:Smooth Muscle Contraction", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-MMU-422356:r:Regulation of insulin secretion", "R-HSA-1300642:r:Sperm Motility And Taxes", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-2672351:r:Stimuli-sensing channels", "R-DME-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DRE-1222556:r:ROS and RNS production in phagocytes", "R-DRE-2672351:r:Stimuli-sensing channels", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-1296072:r:Voltage gated Potassium channels", "R-MMU-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-HSA-445355:r:Smooth Muscle Contraction", "R-CEL-1300642:r:Sperm Motility And Taxes", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-GGA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-422356:r:Regulation of insulin secretion", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-HSA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-SCE-445355:r:Smooth Muscle Contraction", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Homologous_superfamily"}, "IPR027360": {"description": "AbrB-like transcriptional regulator", "go_ids": [], "go_terms": [], "name": "AbrB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027362": {"description": "DNA topoisomerase I, C-terminal", "go_ids": [], "go_terms": [], "name": "TopoI_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027363": {"description": "Methylthioribose-1-phosphate isomerase, N-terminal", "go_ids": [], "go_terms": [], "name": "M1Pi_N", "pathway_ids": ["PWY-7174", "PWY-8130", "PWY-8132", "PWY-8131", "PWY-4361", "R-DRE-1237112", "R-SCE-72731", "R-SPO-1237112", "R-RNO-1237112", "R-SPO-72731", "R-MMU-1237112", "R-XTR-1237112", "R-CEL-1237112", "R-DME-1237112", "R-HSA-1237112"], "pathways": ["PWY-7174:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II", "PWY-8130:t:5'-deoxyadenosine degradation I", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8131:t:5'-deoxyadenosine degradation II", "PWY-4361:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I", "R-DRE-1237112:r:Methionine salvage pathway", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-SPO-1237112:r:Methionine salvage pathway", "R-RNO-1237112:r:Methionine salvage pathway", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-MMU-1237112:r:Methionine salvage pathway", "R-XTR-1237112:r:Methionine salvage pathway", "R-CEL-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-HSA-1237112:r:Methionine salvage pathway"], "type": "Homologous_superfamily"}, "IPR027365": {"description": "GNAT acetyltransferase YdfB-like", "go_ids": [], "go_terms": [], "name": "GNAT_acetyltra_YdfB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027367": {"description": "YMGG-like Gly-zipper", "go_ids": [], "go_terms": [], "name": "Gly-zipper_YMGG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027368": {"description": "tRNA modification GTPase MnmE domain 2", "go_ids": [], "go_terms": [], "name": "MnmE_dom2", "pathway_ids": ["R-HSA-6787450"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Homologous_superfamily"}, "IPR027370": {"description": "Zinc finger, RING-type, eukaryotic", "go_ids": [], "go_terms": [], "name": "Znf-RING_euk", "pathway_ids": ["PWY-7511", "R-HSA-9833109", "R-BTA-983168", "R-DDI-354192", "R-MMU-9909505", "R-HSA-9705671", "R-HSA-901032", "R-HSA-168928", "R-HSA-9833482", "R-HSA-5689896", "R-HSA-9920588", "R-HSA-933542", "R-MMU-9861718", "R-HSA-936440", "R-RNO-5357905", "R-HSA-1169408", "R-MMU-5357956", "R-DDI-9013149", "R-HSA-9909505", "R-DRE-8866654", "R-DRE-983168", "R-HSA-9861718", "R-HSA-918233", "R-MMU-9833482", "R-DDI-381676", "R-HSA-9615017", "R-HSA-5357905", "R-DDI-9013423", "R-HSA-9833110", "R-HSA-5656169", "R-DDI-193648", "R-MMU-5357786", "R-DDI-171007", "R-DRE-9843940", "R-SSC-983168", "R-DRE-9013424", "R-DDI-392517", "R-MMU-3134975", "R-MMU-5656169", "R-DDI-5673001", "R-HSA-983168", "R-MMU-1169408", "R-HSA-5357786", "R-DRE-3899300", "R-HSA-8866654", "R-HSA-933541", "R-HSA-5357956", "R-HSA-933543", "R-HSA-877300", "R-HSA-9692916", "R-HSA-3134975", "R-MMU-983168", "R-RNO-5357956", "R-MMU-5357905", "R-RNO-5357786", "R-RNO-983168", "R-DDI-1169092"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-354192:r:Integrin signaling", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DRE-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-9833482:r:PKR-mediated signaling", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-DDI-171007:r:p38MAPK events", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-9013424:r:RHOV GTPase cycle", "R-DDI-392517:r:Rap1 signalling", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-1169092:r:Activation of RAS in B cells"], "type": "Domain"}, "IPR027371": {"description": "Mg296-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Mg296-like_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027372": {"description": "Phytase-like domain", "go_ids": [], "go_terms": [], "name": "Phytase-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027373": {"description": "Ribbon-helix-helix domain", "go_ids": [], "go_terms": [], "name": "RHH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027375": {"description": "DKNYY family", "go_ids": [], "go_terms": [], "name": "DKNYY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027377": {"description": "ZAR1/RTP1-5-like, 3CxxC-type zinc finger", "go_ids": [], "go_terms": [], "name": "ZAR1/RTP1-5-like_Znf-3CxxC", "pathway_ids": ["R-HSA-9752946"], "pathways": ["R-HSA-9752946:r:Expression and translocation of olfactory receptors"], "type": "Domain"}, "IPR027378": {"description": "Cyclic nucleotide-regulated ion channel, N-terminal", "go_ids": [], "go_terms": [], "name": "Nucleotide_channel_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027379": {"description": "Cardiolipin synthase N-terminal", "go_ids": [], "go_terms": [], "name": "CLS_N", "pathway_ids": ["PWY-6580", "PWY-6350", "PWY-7817", "PWY-7981", "PWY-7819", "PWY-6804", "PWY-7820", "PWY-8248", "PWY-7816", "PWY-7818", "PWY-7815"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-6350:t:archaetidylinositol biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-6804:t:diacylglycerol biosynthesis (PUFA enrichment in oilseed)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"], "type": "Domain"}, "IPR027381": {"description": "LytR/CpsA/Psr regulator, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LytR/CpsA/Psr_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027383": {"description": "Putative zinc-finger", "go_ids": [], "go_terms": [], "name": "Znf_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027384": {"description": "Runx, central domain superfamily", "go_ids": [], "go_terms": [], "name": "Runx_central_dom_sf", "pathway_ids": ["R-HSA-2032785", "R-MMU-8941326", "R-HSA-8939256", "R-HSA-9942503", "R-HSA-8936459", "R-MMU-8940973", "R-RNO-8934593", "R-MMU-8939246", "R-MMU-8939247", "R-MMU-8934593", "R-RNO-8939246", "R-MMU-8939245", "R-RNO-9018519", "R-RNO-8939243", "R-RNO-8936459", "R-MMU-8939236", "R-HSA-1912408", "R-HSA-8939236", "R-HSA-8941333", "R-HSA-8939245", "R-HSA-8877330", "R-RNO-8939245", "R-RNO-549127", "R-HSA-9616222", "R-HSA-8878166", "R-MMU-8877330", "R-RNO-8939247", "R-HSA-8941326", "R-HSA-9018519", "R-HSA-8951936", "R-MMU-8931987", "R-MMU-8936459", "R-HSA-8939247", "R-HSA-8931987", "R-RNO-8931987", "R-HSA-8934593", "R-MMU-8878166", "R-MMU-8939243", "R-HSA-8941332", "R-MMU-9018519", "R-RNO-8939236", "R-HSA-8939902", "R-HSA-8939243", "R-HSA-8935964", "R-RNO-8877330", "R-MMU-8939902", "R-HSA-9692916", "R-HSA-549127", "R-HSA-8939246", "R-MMU-549127", "R-HSA-8939242", "R-HSA-8940973", "R-HSA-8941284"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-8941326:r:RUNX2 regulates bone development", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-8940973:r:RUNX2 regulates osteoblast differentiation", "R-RNO-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8941333:r:RUNX2 regulates genes involved in differentiation of myeloid cells", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-RNO-549127:r:SLC-mediated transport of organic cations", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-MMU-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-MMU-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-RNO-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-RNO-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-549127:r:SLC-mediated transport of organic cations", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation"], "type": "Homologous_superfamily"}, "IPR027385": {"description": "Outer membrane protein, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "Beta-barrel_OMP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027386": {"description": "Ribosomal uL15, N-terminal", "go_ids": [], "go_terms": [], "name": "Rbsml_uL15_N", "pathway_ids": ["R-RNO-9629569", "R-HSA-9954716", "R-BTA-975957", "R-MMU-72689", "R-HSA-9010553", "R-HSA-156827", "R-RNO-72689", "R-RNO-1799339", "R-MMU-9954709", "R-BTA-72689", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-BTA-72706", "R-RNO-9954716", "R-BTA-9629569", "R-HSA-9954709", "R-MMU-975956", "R-HSA-9629569", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-HSA-9633012", "R-MMU-9954714", "R-RNO-156827", "R-BTA-9954716", "R-BTA-6791226", "R-MMU-975957", "R-HSA-156902", "R-HSA-72706", "R-HSA-72689", "R-HSA-72764", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-RNO-6791226", "R-MMU-9629569", "R-HSA-975957", "R-HSA-6791226", "R-RNO-975956", "R-BTA-975956", "R-RNO-9954709", "R-BTA-9954709", "R-HSA-9954714", "R-RNO-72706", "R-RNO-9954714", "R-MMU-1799339"], "pathways": ["R-RNO-9629569:r:Protein hydroxylation", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-192823:r:Viral mRNA Translation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-9629569:r:Protein hydroxylation", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9629569:r:Protein hydroxylation", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-9629569:r:Protein hydroxylation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Homologous_superfamily"}, "IPR027387": {"description": "Cytochrome b/b6-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Cytb/b6-like_sf", "pathway_ids": ["R-HSA-9865881", "R-HSA-5419276", "R-DDI-611105", "R-DRE-611105", "R-DRE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-RNO-5419276", "R-CEL-611105", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-BTA-9865881", "R-RNO-9865881", "R-SPO-611105", "R-CEL-5419276", "R-SCE-611105", "R-DRE-5419276", "R-BTA-611105", "R-DME-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DDI-611105:r:Respiratory electron transport", "R-DRE-611105:r:Respiratory electron transport", "R-DRE-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-5419276:r:Mitochondrial translation termination", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-BTA-9865881:r:Complex III assembly", "R-RNO-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-CEL-5419276:r:Mitochondrial translation termination", "R-SCE-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR027388": {"description": "Ku70, bridge and pillars domain superfamily", "go_ids": [], "go_terms": [], "name": "Ku70_bridge/pillars_dom_sf", "pathway_ids": ["R-HSA-3270619", "R-HSA-6798695", "R-SPO-6798695", "R-HSA-5693571", "R-DDI-6798695", "R-GGA-353423", "R-DME-6798695", "R-DDI-5693571", "R-HSA-1834949", "R-MMU-6798695", "R-MMU-5693571", "R-HSA-164843"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-6798695:r:Neutrophil degranulation", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Homologous_superfamily"}, "IPR027389": {"description": "Beta-1,4-mannosyltransferase Bre-3/Egh", "go_ids": ["GO:0019187"], "go_terms": ["GO:0019187:beta-1,4-mannosyltransferase activity:F"], "name": "B_mannosylTrfase_Bre-3/Egh", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR027390": {"description": "Endoglucanase F, domain 3", "go_ids": [], "go_terms": [], "name": "Endoglucanase_F_dom3", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027391": {"description": "rRNA small subunit methyltransferase F, RNA-binding PUA-like domain", "go_ids": [], "go_terms": [], "name": "Nol1_Nop2_Fmu_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027392": {"description": "Transcription factor zinc-finger", "go_ids": [], "go_terms": [], "name": "TF_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027393": {"description": "Virus scaffolding protein, C-terminal", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Virus_scaffolding_prot_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027394": {"description": "Cytochrome-c3 hydrogenase, C-terminal", "go_ids": [], "go_terms": [], "name": "Cytochrome-c3_hydrogenase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027395": {"description": "Winged helix DNA-binding domain", "go_ids": [], "go_terms": [], "name": "WH_DNA-bd_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027396": {"description": "DsrEFH-like", "go_ids": [], "go_terms": [], "name": "DsrEFH-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027397": {"description": "Catenin binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Catenin-bd_sf", "pathway_ids": ["R-DRE-9768727", "R-DRE-4641265", "R-RNO-1474228", "R-MMU-4086398", "R-MMU-9013408", "R-RNO-525793", "R-HSA-9764562", "R-HSA-418990", "R-DME-390150", "R-RNO-9825892", "R-HSA-5218920", "R-CFA-418990", "R-RNO-6805567", "R-HSA-9616222", "R-DME-390023", "R-HSA-9834899", "R-HSA-1474228", "R-DRE-3769402", "R-CFA-351906", "R-DRE-9764561", "R-MMU-4641265", "R-MMU-351906", "R-DME-6809371", "R-HSA-9696264", "R-MMU-9013423", "R-DRE-9766229", "R-DRE-381426", "R-MMU-216083", "R-HSA-9762292", "R-HSA-9793380", "R-MMU-9696264", "R-HSA-9768727", "R-MMU-9768727", "R-MMU-9766229", "R-SSC-9696270", "R-SSC-6798695", "R-RNO-216083", "R-DRE-1474228", "R-RNO-351906", "R-HSA-9824272", "R-HSA-9013423", "R-DRE-9696264", "R-SSC-5218920", "R-MMU-8951430", "R-HSA-4086398", "R-GGA-381426", "R-HSA-6805567", "R-DRE-8957275", "R-DRE-9825892", 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(IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-XTR-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-6809371:r:Formation of the cornified envelope", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-RNO-8951430:r:RUNX3 regulates WNT signaling", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-DME-209421:r:Transcription activation by ARM", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-SSC-9696264:r:RND3 GTPase cycle", "R-RNO-4641265:r:Repression of WNT target genes", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-3769402:r:Deactivation of the beta-catenin 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cornified envelope", "R-RNO-9764561:r:Regulation of CDH1 Function", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-4641265:r:Repression of WNT target genes", "R-GGA-418990:r:Adherens junctions interactions", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-XTR-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-4086398:r:Ca2+ pathway", "R-SSC-6809371:r:Formation of the cornified envelope", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DRE-525793:r:Myogenesis", "R-DME-9013423:r:RAC3 GTPase cycle"], 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"R-CEL-450385", "R-BTA-450385", "R-DDI-6791226", "R-MMU-429958", "R-RNO-450513", "R-SPO-9930044", "R-XTR-450513", "R-RNO-9930044", "R-SCE-450385", "R-RNO-450604", "R-DRE-9930044", "R-SCE-429958", "R-HSA-380994", "R-HSA-9836573", "R-SCE-6791226", "R-CEL-429958", "R-RNO-450385", "R-CEL-6791226", "R-HSA-429958", "R-SPO-429958", "R-MMU-9930044", "R-MMU-6791226", "R-BTA-429958", "R-DDI-429958", "R-DRE-450513", "R-XTR-429958", "R-BTA-6791226", "R-BTA-450513", "R-DRE-450604", "R-SCE-450513", "R-DRE-429958", "R-XTR-450604", "R-CEL-450513", "R-BTA-9930044", "R-RNO-6791226", "R-HSA-450385", "R-XTR-9930044", "R-RNO-429958", "R-MMU-450513", "R-HSA-6791226", "R-DDI-450385", "R-MMU-450604", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-DDI-450513", "R-SPO-6791226", "R-DDI-9930044"], "pathways": ["R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-450385:r:Butyrate Response Factor 1 (BRF1) binds and 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[], "type": "Homologous_superfamily"}, "IPR027413": {"description": "GroEL-like equatorial domain superfamily", "go_ids": [], "go_terms": [], "name": "GROEL-like_equatorial_sf", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-MMU-9837999", "R-HSA-9013422", "R-HSA-9013418", "R-HSA-5620922", "R-RNO-9013422", "R-SPO-6814122", "R-SCE-6814122", "R-RNO-5620922", "R-CEL-6798695", "R-SCE-6798695", "R-BTA-6798695", "R-CEL-6814122", "R-DDI-9013422", "R-BTA-390471", "R-DDI-6814122", "R-HSA-8869496", "R-MMU-9013422", "R-DME-390471", "R-HSA-1268020", "R-SPO-390471", "R-MMU-1268020", "R-RNO-390471", "R-BTA-9013418", "R-HSA-9837999", "R-SCE-1268020", "R-SCE-390471", "R-MMU-9013418", "R-BTA-6814122", "R-PFA-6814122", "R-RNO-1268020", "R-RNO-9013418", "R-MMU-6814122", "R-DDI-6798695", "R-DDI-9837999", "R-BTA-5620922", "R-HSA-390450", "R-HSA-390471", "R-CEL-9837999", "R-GGA-1268020", "R-DME-9837999", "R-DDI-390471", "R-HSA-9841251", "R-MMU-390471", "R-HSA-8950505", "R-RNO-9837999", "R-SPO-1268020", 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during biosynthesis", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SPO-1268020:r:Mitochondrial protein import", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-389960:r:Formation of tubulin folding intermediates by CCT/TriC", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-GGA-9837999:r:Mitochondrial protein degradation", "R-CEL-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-389957:r:Prefoldin mediated transfer of substrate to CCT/TriC", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Homologous_superfamily"}, "IPR027414": {"description": "Glycosyl hydrolase family 95, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GH95_N_dom", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR027417": {"description": "P-loop containing nucleoside triphosphate hydrolase", "go_ids": [], "go_terms": [], "name": "P-loop_NTPase", "pathway_ids": ["R-MMU-6798695", "R-SCE-5620916", "R-DDI-381042", "R-RNO-6794361", "R-DDI-9758890", "R-HSA-189451", "R-MMU-114608", "R-MMU-1799339", "R-HSA-416550", "R-MMU-5610780", "R-HSA-3108214", "R-DDI-1660499", "R-XTR-499943", "R-CEL-68867", "R-DDI-75815", "R-RNO-2029482", "R-RNO-5668599", "R-DRE-77075", "R-MMU-9634600", "R-BTA-69166", "R-HSA-1169092", "R-BTA-5693579", "R-HSA-432722", "R-BTA-174178", "R-MMU-8949613", "R-HSA-380972", "R-HSA-9931509", "R-DME-170968", 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"R-HSA-169911", "R-SSC-917937", "R-DRE-9668328", "R-MMU-9762114", "R-BTA-5696400", "R-HSA-9603798", "R-MMU-195253", "R-SPO-198203", "R-SCE-983189", "R-MMU-3928664", "R-BTA-8856828", "R-MMU-382556", "R-DDI-1632852", "R-MMU-68884", "R-RNO-75815", "R-MMU-1169091", "R-DME-418594", "R-RNO-72702", "R-HSA-380270", "R-PFA-73817", "R-DRE-844456", "R-HSA-9726842", "R-DME-8854050", "R-RNO-9856530", "R-GGA-5654712", "R-GGA-1250347", "R-HSA-5693571", "R-RNO-9770562", "R-CEL-198203", "R-DME-5419276", "R-HSA-8875656", "R-SPO-68949", "R-RNO-9954714", "R-MMU-5607764", "R-CFA-1268020", "R-DME-69052", "R-BTA-5668541", "R-DME-5656121", "R-CEL-438066", "R-CFA-1799339", "R-CEL-2453902", "R-RNO-8939243", "R-HSA-8849471", "R-BTA-3928663", "R-SSC-9856530", "R-DME-2424491", "R-HSA-2142845", "R-RNO-196025", "R-RNO-5419276", "R-GGA-5687128", "R-CEL-203927", "R-BTA-72695", "R-RNO-9013406", "R-CFA-5627117", "R-BTA-381042", "R-DDI-1660517", "R-CEL-9013148", "R-HSA-5655302", "R-SCE-68867", "R-DME-438066", "R-MMU-5620924", "R-HSA-5621480", "R-HSA-5601884", "R-CEL-1369007", "R-MMU-193634", "R-BTA-5576893", "R-BTA-2485179", "R-SCE-917977", "R-RNO-72203", "R-BTA-69052", "R-MMU-438066", "R-DME-9629569", "R-HSA-8950505", "R-DDI-2514853", "R-HSA-110312", "R-RNO-381042", "R-MMU-6811436", "R-HSA-9013149", "R-HSA-1169091", "R-HSA-8980692", "R-HSA-5658442", "R-MMU-5358493", "R-DME-181430", "R-BTA-8852276", "R-MMU-390247", "R-HSA-3134975", "R-DRE-416482", "R-HSA-5654704", "R-MMU-5389840", "R-SCE-392517", "R-BTA-168638", "R-BTA-6796648", "R-DDI-1169408", "R-SPO-9707564", "R-DDI-68616", "R-GGA-171007", "R-DRE-5689880", "R-SPO-5696397", "R-MTU-964903", "R-GGA-2022928", "R-HSA-1222538", "R-CEL-9954709", "R-BTA-8949664", "R-SPO-72695", "R-DME-9013419", "R-MMU-73863", "R-MMU-5685942", "R-DDI-75153", "R-DME-5627117", "R-MMU-8876725", "R-DME-8849932", "R-HSA-8985586", "R-MMU-9013026", "R-GGA-5654688", "R-BTA-499943", "R-RNO-5610785", "R-DME-8849471", "R-BTA-141444", "R-DME-68867", "R-RNO-170670", "R-HSA-5627117", "R-SPO-2142691", "R-DME-190873", "R-RNO-1250347", "R-MMU-75953", "R-DDI-77387", "R-HSA-6802952", "R-SPO-5656169", "R-RNO-9013409", "R-CFA-3928663", "R-HSA-420029", "R-CFA-8854214", "R-GGA-351433", "R-HSA-2485179", "R-HSA-9918487", "R-RNO-2142845", "R-RNO-110314", "R-MMU-8948751", "R-DME-8948751", "R-RNO-416550", "R-RNO-5218920", "R-HSA-72695", "R-DDI-389359", "R-RNO-399954", "R-DME-72086", "R-HSA-69052", "R-BTA-1169091", "R-HSA-9844594", "R-DME-2453902", "R-MMU-3371511", "R-BTA-2500257", "R-DME-5676590", "R-GGA-2179392", "R-CFA-2132295", "R-DRE-416550", "R-HSA-392170", "R-SPO-69166", "R-CFA-6811440", "R-DDI-9634635", "R-BTA-75955", "R-SCE-1222556", "R-SPO-176187", "R-HSA-5607761", "R-RNO-5682910", "R-DDI-174084", "R-BTA-9013425", "R-RNO-74217", "R-MMU-9932298", "R-DME-6785631", "R-BTA-72702", "R-GGA-9954716", "R-HSA-419037", "R-HSA-8866654", "R-SCE-68616", "R-RNO-456926", "R-MMU-9933939", "R-DME-416572", "R-HSA-9748787", "R-CEL-8851805", "R-SPO-77387", "R-CEL-6782135", "R-BTA-8875555", "R-RNO-9954709", "R-MMU-170984", "R-DRE-9953170", "R-DRE-9948001", "R-RNO-9627069", "R-CEL-8948751", "R-CFA-399719", "R-CEL-6811558", "R-RNO-5620924", "R-MMU-9013418", "R-MMU-9766229", "R-MMU-354192", "R-DDI-187577", "R-HSA-72662", "R-SCE-429947", "R-HSA-9833109", "R-RNO-1234176", "R-BTA-1236978", "R-GGA-9013424", "R-PFA-499943", "R-GGA-5685942", "R-MMU-77595", "R-HSA-191650", "R-SCE-381676", "R-GGA-8876725", "R-HSA-9934037", "R-BTA-983231", "R-MMU-8964616", "R-DRE-983168", "R-GGA-5627123", "R-BTA-4086398", "R-RNO-416482", "R-RNO-389359", "R-DDI-9018519", "R-RNO-3928662", "R-DRE-5625970", "R-XTR-9668328", "R-SCE-9753281", "R-RNO-2022870", "R-MMU-975956", "R-HSA-196025", "R-CEL-8856828", "R-HSA-9770562", "R-HSA-5655332", "R-RNO-6796648", "R-DME-5654719", "R-GGA-5693568", "R-RNO-5626467", "R-DDI-112043", "R-DDI-5675221", "R-CFA-9696273", "R-DME-9833482", "R-DME-6811434", "R-PFA-9757110", "R-RNO-9032759", "R-SPO-110320", "R-RNO-9634600", "R-HSA-427389", "R-HSA-6814122", "R-DDI-4086398", "R-DRE-4420097", "R-HSA-180746", "R-CEL-114604", "R-SCE-73772", "R-BTA-2142691", "R-DME-5689880", "R-SPO-350562", "R-HSA-9953170", "R-RNO-110312", "R-DRE-5674135", "R-HSA-9920588", "R-RNO-674695", "R-HSA-5689896", "R-HSA-8856828", "R-DME-3371497", "R-BTA-202424", "R-DME-76042", "R-DDI-1834941", "R-MMU-5689901", "R-SCE-9707564", "R-DRE-141444", "R-MMU-5205685", "R-MMU-2565942", "R-BTA-912446", "R-HSA-5694530", "R-MMU-111459", "R-BTA-5576892", "R-SCE-9770562", "R-MMU-5696395", "R-DRE-6798695", "R-GGA-6782135", "R-SSC-73856", "R-DME-4608870", "R-GGA-3928662", "R-RNO-9748787", "R-SCE-199992", "R-GGA-8856828", "R-CEL-525793", "R-MMU-5620916", "R-HSA-451308", "R-RNO-5205685", "R-GGA-9013148", "R-RNO-432720", "R-PFA-9646399", "R-MMU-2559586", "R-CEL-5628897", "R-HSA-9933947", "R-SSC-9013406", "R-HSA-9694614", "R-CFA-382556", "R-HSA-9735869", "R-HSA-4641258", "R-DRE-5696394", "R-RNO-5578749", "R-CFA-5685938", "R-CFA-209563", "R-SPO-9770562", "R-BTA-4641258", "R-DME-203927", "R-MMU-8876198", "R-SCE-2029482", "R-SCE-156842", "R-HSA-8853884", "R-CEL-375165", "R-MMU-2022870", "R-RNO-201722", "R-DME-77595", "R-DME-382556", "R-CEL-1632852", "R-DME-5610780", "R-CEL-437239", "R-HSA-5358606", "R-HSA-9857377", "R-DME-350368", "R-CEL-73856", "R-HSA-416476", "R-PFA-983170", "R-MMU-69601", "R-CEL-418885", "R-SCE-975957", "R-DME-209159", "R-DME-5607761", "R-MMU-8854050", "R-MMU-611105", "R-HSA-5578775", "R-HSA-9619229", "R-MMU-9648025", "R-HSA-5620912", "R-CFA-983231", "R-BTA-68689", "R-HSA-163358", "R-SCE-6796648", "R-HSA-354192", "R-MMU-416993", "R-GGA-2871796", "R-HSA-193648", "R-RNO-2559586", "R-DDI-416482", "R-DRE-111459", "R-RNO-1963640", "R-CEL-196025", "R-RNO-6782135", "R-DME-9837999", "R-MMU-6794361", "R-RNO-9634635", "R-CEL-6811436", "R-DDI-2046106", "R-DRE-975957", "R-CEL-8876725", "R-MMU-181429", "R-SSC-434316", "R-HSA-9708296", "R-RNO-204005", "R-MMU-156902", "R-HSA-1236394", "R-RNO-69091", "R-GGA-975957", "R-SCE-9907900", "R-MMU-8963896", "R-RNO-163841", "R-DRE-8876725", "R-RNO-8873719", "R-BTA-422356", "R-MMU-2424491", "R-CEL-1660499", "R-SCE-3371511", "R-DME-4420097", "R-CFA-193648"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-381042:r:PERK regulates gene expression", "R-RNO-6794361:r:Neurexins and neuroligins", "R-DDI-9758890:r:Transport of RCbl within the body", "R-HSA-189451:r:Heme biosynthesis", "R-MMU-114608:r:Platelet degranulation", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-XTR-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-68867:r:Assembly of the pre-replicative complex", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-HSA-1169092:r:Activation of RAS in B cells", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-8949613:r:Cristae formation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-DME-170968:r:Frs2-mediated activation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-983712:r:Ion channel transport", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-DRE-72086:r:mRNA Capping", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-SPO-8876725:r:Protein methylation", "R-DME-3371511:r:HSF1 activation", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-912446:r:Meiotic recombination", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DRE-72649:r:Translation initiation complex formation", "R-HSA-983712:r:Ion channel transport", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-DDI-159418:r:Recycling of bile acids and salts", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-5419276:r:Mitochondrial translation termination", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-170670:r:Adenylate cyclase inhibitory pathway", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-SSC-8875656:r:MET receptor recycling", "R-MMU-9753281:r:Paracetamol ADME", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-RNO-9753281:r:Paracetamol ADME", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210993:r:Tie2 Signaling", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-114608:r:Platelet degranulation", "R-DME-445355:r:Smooth Muscle Contraction", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-MMU-8854214:r:TBC/RABGAPs", "R-DME-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-GGA-5658442:r:Regulation of RAS by GAPs", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-844455:r:The NLRP1 inflammasome", "R-DDI-68867:r:Assembly of the pre-replicative complex", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-DRE-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CFA-8980692:r:RHOA GTPase cycle", "R-MMU-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-BTA-182971:r:EGFR downregulation", "R-PFA-6811438:r:Intra-Golgi traffic", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DME-196025:r:Formation of annular gap junctions", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DDI-3371511:r:HSF1 activation", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DRE-9603798:r:Class I peroxisomal membrane protein import", "R-DRE-5689603:r:UCH proteinases", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-SPO-190873:r:Gap junction degradation", "R-DME-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-164378:r:PKA activation in glucagon signalling", "R-DME-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-1632852:r:Macroautophagy", "R-HSA-9670613:r:Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-DDI-3899300:r:SUMOylation of transcription cofactors", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-GGA-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-5683371:r:Defective ABCB6 causes MCOPCB7", "R-SCE-8876725:r:Protein methylation", "R-MTU-936635:r:Sulfate assimilation", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-9674519:r:Defective F8 sulfation at Y1699", "R-SPO-72764:r:Eukaryotic Translation Termination", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-SCE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-392517:r:Rap1 signalling", "R-MMU-190873:r:Gap junction degradation", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-354192:r:Integrin signaling", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-BTA-437239:r:Recycling pathway of L1", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-SPO-9013420:r:RHOU GTPase cycle", "R-DME-9031628:r:NGF-stimulated transcription", "R-DME-416476:r:G alpha (q) signalling events", "R-SCE-1369007:r:Mitochondrial ABC transporters", "R-BTA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-170660:r:Adenylate cyclase activating pathway", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-SPO-159418:r:Recycling of bile acids and salts", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-MMU-437239:r:Recycling pathway of L1", "R-GGA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-SSC-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-SCE-9696264:r:RND3 GTPase cycle", "R-DDI-9629569:r:Protein hydroxylation", "R-DDI-9907900:r:Proteasome assembly", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DDI-166208:r:mTORC1-mediated signalling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9760173:r:Secretion of toxins", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-MMU-75153:r:Apoptotic execution phase", "R-SCE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-SPO-9748787:r:Azathioprine ADME", "R-SPO-75153:r:Apoptotic execution phase", "R-HSA-156584:r:Cytosolic sulfonation of small molecules", "R-SCE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-DDI-354192:r:Integrin signaling", "R-CFA-4086400:r:PCP/CE pathway", "R-CEL-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-BTA-196025:r:Formation of annular gap junctions", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-9013424:r:RHOV GTPase cycle", "R-HSA-9918454:r:Defective visual phototransduction due to ABCA4 loss of function", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-SCE-69091:r:Polymerase switching", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-DME-4086400:r:PCP/CE pathway", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SSC-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-420092:r:Glucagon-type ligand receptors", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-428930:r:Thromboxane signalling through TP receptor", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-RNO-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SCE-9013420:r:RHOU GTPase cycle", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-6785631:r:ERBB2 Regulates Cell Motility", "R-XTR-392517:r:Rap1 signalling", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DDI-2470946:r:Cohesin Loading onto Chromatin", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-9748787:r:Azathioprine ADME", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-CEL-4641258:r:Degradation of DVL", "R-DDI-418597:r:G alpha (z) signalling events", "R-SCE-198203:r:PI3K/AKT activation", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-DME-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CEL-9833482:r:PKR-mediated signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9754706:r:Atorvastatin ADME", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-CEL-8949664:r:Processing of SMDT1", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-SPO-429947:r:Deadenylation of mRNA", "R-CFA-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-5625900:r:RHO GTPases activate CIT", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5689901:r:Metalloprotease DUBs", "R-CFA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5684045:r:Defective ABCD1 causes ALD", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SCE-8873719:r:RAB geranylgeranylation", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9953170:r:GBP-mediated host defense", "R-CFA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-68949:r:Orc1 removal from chromatin", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DME-110312:r:Translesion synthesis by REV1", "R-RNO-9845576:r:Glycosphingolipid transport", "R-SPO-9013409:r:RHOJ GTPase cycle", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-BTA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DRE-5419276:r:Mitochondrial translation termination", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-9748787:r:Azathioprine ADME", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DRE-3371511:r:HSF1 activation", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-DME-77387:r:Insulin receptor recycling", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CFA-9013420:r:RHOU GTPase cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-538864:r:Degradation of CRY", "R-XTR-983189:r:Kinesins", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-73614:r:Pyrimidine salvage", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-198203:r:PI3K/AKT activation", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-166208:r:mTORC1-mediated signalling", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-CEL-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-RNO-912446:r:Meiotic recombination", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-CFA-9013409:r:RHOJ GTPase cycle", "R-MMU-8963888:r:Chylomicron assembly", "R-DDI-8873719:r:RAB geranylgeranylation", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-DRE-390247:r:Beta-oxidation of very long chain fatty acids", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-2028269:r:Signaling by Hippo", "R-HSA-8951664:r:Neddylation", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-MMU-1632852:r:Macroautophagy", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DRE-1250347:r:SHC1 events in ERBB4 signaling", "R-CFA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SSC-2132295:r:MHC class II antigen presentation", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-CEL-9770562:r:mRNA Polyadenylation", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-182971:r:EGFR downregulation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-165159:r:MTOR signalling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-9607240:r:FLT3 Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DRE-1169092:r:Activation of RAS in B cells", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-5679090:r:Defective ABCG8 causes GBD4 and sitosterolemia", "R-HSA-196807:r:Nicotinate metabolism", "R-DRE-186763:r:Downstream signal transduction", "R-HSA-373752:r:Netrin-1 signaling", "R-PFA-9845576:r:Glycosphingolipid transport", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-6811438:r:Intra-Golgi traffic", "R-DME-2046105:r:Linoleic acid (LA) metabolism", "R-BTA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-GGA-110312:r:Translesion synthesis by REV1", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-171007:r:p38MAPK events", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-8854214:r:TBC/RABGAPs", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-6785631:r:ERBB2 Regulates Cell Motility", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72086:r:mRNA Capping", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-198203:r:PI3K/AKT activation", "R-CEL-9031628:r:NGF-stimulated transcription", "R-RNO-9013420:r:RHOU GTPase cycle", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DRE-114608:r:Platelet degranulation", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-CEL-3371511:r:HSF1 activation", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-844455:r:The NLRP1 inflammasome", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SSC-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-9824272:r:Somitogenesis", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-166208:r:mTORC1-mediated signalling", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-429947:r:Deadenylation of mRNA", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-BTA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-GGA-9013408:r:RHOG GTPase cycle", "R-PFA-9754706:r:Atorvastatin ADME", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-72764:r:Eukaryotic Translation Termination", "R-SCE-75153:r:Apoptotic execution phase", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-RNO-437239:r:Recycling pathway of L1", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-156842:r:Eukaryotic Translation Elongation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-CFA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-983712:r:Ion channel transport", "R-DDI-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-209563:r:Axonal growth stimulation", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CFA-112043:r:PLC beta mediated events", "R-DDI-2142845:r:Hyaluronan metabolism", "R-PFA-382556:r:ABC-family proteins mediated transport", "R-CFA-72187:r:mRNA 3'-end processing", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-5689603:r:UCH proteinases", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-XTR-9013407:r:RHOH GTPase cycle", "R-CEL-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SPO-72086:r:mRNA Capping", "R-MMU-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-CEL-8854214:r:TBC/RABGAPs", "R-CEL-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-1266695:r:Interleukin-7 signaling", "R-GGA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-69481:r:G2/M Checkpoints", "R-MMU-6799198:r:Complex I biogenesis", "R-CFA-9032759:r:NTRK2 activates RAC1", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-2161517:r:Abacavir transmembrane transport", "R-SSC-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-2142845:r:Hyaluronan metabolism", "R-GGA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-SPO-5689603:r:UCH proteinases", "R-DME-611105:r:Respiratory electron transport", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-SCE-2046105:r:Linoleic acid (LA) metabolism", "R-DME-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-9013425:r:RHOT1 GTPase cycle", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-169911:r:Regulation of Apoptosis", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-9648002:r:RAS processing", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-DME-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-9754706:r:Atorvastatin ADME", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-CEL-9646399:r:Aggrephagy", "R-DME-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-DDI-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DME-9013409:r:RHOJ GTPase cycle", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-SPO-8873719:r:RAB geranylgeranylation", "R-CEL-6811438:r:Intra-Golgi traffic", "R-DRE-5627083:r:RHO GTPases regulate CFTR trafficking", "R-HSA-8851805:r:MET activates RAS signaling", "R-DDI-2046105:r:Linoleic acid (LA) metabolism", "R-SSC-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DDI-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-73614:r:Pyrimidine salvage", "R-RNO-390522:r:Striated Muscle Contraction", "R-MMU-2028269:r:Signaling by Hippo", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-CEL-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-SSC-2424491:r:DAP12 signaling", "R-MMU-9033241:r:Peroxisomal protein import", "R-SPO-9035034:r:RHOF GTPase cycle", "R-CFA-5625900:r:RHO GTPases activate CIT", "R-BTA-5689603:r:UCH proteinases", "R-SCE-72649:r:Translation initiation complex formation", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-165159:r:MTOR signalling", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-BTA-8854214:r:TBC/RABGAPs", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-SSC-5673000:r:RAF activation", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-MMU-1266695:r:Interleukin-7 signaling", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-SCE-196807:r:Nicotinate metabolism", "R-RNO-9607240:r:FLT3 Signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-CEL-5673000:r:RAF activation", "R-DDI-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-525793:r:Myogenesis", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-447038:r:NrCAM interactions", "R-CFA-9837999:r:Mitochondrial protein degradation", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-GGA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-5694530:r:Cargo concentration in the ER", "R-HSA-73614:r:Pyrimidine salvage", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-CFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-4086400:r:PCP/CE pathway", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-DME-2022923:r:DS-GAG biosynthesis", "R-CEL-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-RNO-111457:r:Release of apoptotic factors from the mitochondria", "R-RNO-611105:r:Respiratory electron transport", "R-RNO-8851805:r:MET activates RAS signaling", "R-RNO-8951664:r:Neddylation", "R-CFA-8875656:r:MET receptor recycling", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-BTA-156902:r:Peptide chain elongation", "R-MMU-5682910:r:LGI-ADAM interactions", "R-CFA-198203:r:PI3K/AKT activation", "R-DRE-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-GGA-69091:r:Polymerase switching", "R-HSA-9648002:r:RAS processing", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-BTA-9833482:r:PKR-mediated signaling", "R-DDI-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SPO-196807:r:Nicotinate metabolism", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DME-429947:r:Deadenylation of mRNA", "R-DME-6799198:r:Complex I biogenesis", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8949664:r:Processing of SMDT1", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SSC-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-SSC-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-CEL-2485179:r:Activation of the phototransduction cascade", "R-RNO-5694530:r:Cargo concentration in the ER", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-8964058:r:HDL remodeling", "R-SSC-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-8963888:r:Chylomicron assembly", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-77387:r:Insulin receptor recycling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-5625970:r:RHO GTPases activate KTN1", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-6799198:r:Complex I biogenesis", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CFA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-CEL-5689877:r:Josephin domain DUBs", "R-DRE-156902:r:Peptide chain elongation", "R-DDI-189451:r:Heme biosynthesis", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-GGA-68949:r:Orc1 removal from chromatin", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-PFA-5693548:r:Sensing of DNA Double Strand Breaks", "R-SSC-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-416476:r:G alpha (q) signalling events", "R-CEL-1169092:r:Activation of RAS in B cells", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DME-4641257:r:Degradation of AXIN", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-SCE-77387:r:Insulin receptor recycling", "R-HSA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-983712:r:Ion channel transport", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-165159:r:MTOR signalling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-DRE-6782135:r:Dual incision in TC-NER", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-1369007:r:Mitochondrial ABC transporters", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DME-5696400:r:Dual Incision in GG-NER", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-SCE-6811438:r:Intra-Golgi traffic", "R-DRE-1369007:r:Mitochondrial ABC transporters", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9013420:r:RHOU GTPase cycle", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CFA-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-182971:r:EGFR downregulation", "R-CFA-2424491:r:DAP12 signaling", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-CEL-9013424:r:RHOV GTPase cycle", "R-GGA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-MMU-189483:r:Heme degradation", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-1268020:r:Mitochondrial protein import", "R-DME-1266695:r:Interleukin-7 signaling", "R-CEL-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-392517:r:Rap1 signalling", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-381753:r:Olfactory Signaling Pathway", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-XTR-8875555:r:MET activates RAP1 and RAC1", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SSC-525793:r:Myogenesis", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-CEL-983189:r:Kinesins", "R-DME-445144:r:Signal transduction by L1", "R-SPO-6811438:r:Intra-Golgi traffic", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-BTA-73614:r:Pyrimidine salvage", "R-XTR-114608:r:Platelet degranulation", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-4641258:r:Degradation of DVL", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-BTA-114608:r:Platelet degranulation", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-9757110:r:Prednisone ADME", "R-SCE-196783:r:Coenzyme A biosynthesis", "R-DDI-170670:r:Adenylate cyclase inhibitory pathway", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-DRE-9840373:r:Cellular response to mitochondrial stress", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SSC-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-418597:r:G alpha (z) signalling events", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-CEL-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-9953170:r:GBP-mediated host defense", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-GGA-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-8949613:r:Cristae formation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-844456:r:The NLRP3 inflammasome", "R-MMU-209563:r:Axonal growth stimulation", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-170670:r:Adenylate cyclase inhibitory pathway", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DME-174411:r:Polymerase switching on the C-strand of the telomere", "R-DRE-2022928:r:HS-GAG biosynthesis", "R-CEL-196783:r:Coenzyme A biosynthesis", "R-DDI-74217:r:Purine salvage", "R-DDI-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-RNO-9749641:r:Aspirin ADME", "R-GGA-182971:r:EGFR downregulation", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-9694301:r:Maturation of replicase proteins", "R-GGA-912446:r:Meiotic recombination", "R-HSA-9646399:r:Aggrephagy", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SSC-9607240:r:FLT3 Signaling", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-GGA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-BTA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-HSA-3359478:r:Defective MUT causes MMAM", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-CEL-9607240:r:FLT3 Signaling", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-5655862:r:Translesion synthesis by POLK", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-CFA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-GGA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-9035034:r:RHOF GTPase cycle", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-RNO-4086400:r:PCP/CE pathway", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-5673000:r:RAF activation", "R-RNO-3371511:r:HSF1 activation", "R-GGA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-111458:r:Formation of apoptosome", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DRE-5673000:r:RAF activation", "R-CFA-9013407:r:RHOH GTPase cycle", "R-DRE-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-HSA-191859:r:snRNP Assembly", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-GGA-265976:r:Homologous DNA pairing and strand exchange", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-418594:r:G alpha (i) signalling events", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SCE-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-9907900:r:Proteasome assembly", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-GGA-352882:r:Glycolysis", "R-BTA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-MMU-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-SSC-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-DME-199992:r:trans-Golgi Network Vesicle Budding", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-BTA-3371511:r:HSF1 activation", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-CFA-5625740:r:RHO GTPases activate PKNs", "R-DME-8949613:r:Cristae formation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-1296025:r:ATP sensitive Potassium channels", "R-GGA-421203:r:De novo synthesis of AMP", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-9753281:r:Paracetamol ADME", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CFA-9696270:r:RND2 GTPase cycle", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-RNO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SSC-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-917937:r:Iron uptake and transport", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-GGA-392517:r:Rap1 signalling", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-GGA-5654704:r:SHC-mediated cascade:FGFR3", "R-CFA-912446:r:Meiotic recombination", "R-SPO-983189:r:Kinesins", "R-RNO-3928664:r:Ephrin signaling", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-SSC-5654693:r:FRS-mediated FGFR1 signaling", "R-PFA-68949:r:Orc1 removal from chromatin", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-DDI-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-DME-6794361:r:Neurexins and neuroligins", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-6811438:r:Intra-Golgi traffic", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DME-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-BTA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-RNO-9020702:r:Interleukin-1 signaling", "R-CEL-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-199992:r:trans-Golgi Network Vesicle Budding", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-202040:r:G-protein activation", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-SPO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-RNO-189483:r:Heme degradation", "R-DME-5674135:r:MAP2K and MAPK activation", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-3928664:r:Ephrin signaling", "R-BTA-72086:r:mRNA Capping", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-BTA-9648002:r:RAS processing", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-SPO-5694530:r:Cargo concentration in the ER", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-196757:r:Metabolism of folate and pterines", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-8949613:r:Cristae formation", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-202040:r:G-protein activation", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-CFA-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-DRE-8875656:r:MET receptor recycling", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-5689877:r:Josephin domain DUBs", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-GGA-418594:r:G alpha (i) signalling events", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-DME-525793:r:Myogenesis", "R-HSA-5679096:r:Defective ABCG5 causes sitosterolemia", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-HSA-6787450:r:tRNA modification in the mitochondrion", "R-MMU-72649:r:Translation initiation complex formation", "R-SCE-159418:r:Recycling of bile acids and salts", "R-HSA-6794361:r:Neurexins and neuroligins", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-DRE-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-GGA-353303:r:Nucleotide Excision Repair", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-CFA-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-216167:r:Nuclear CI is degraded", "R-SCE-9013424:r:RHOV GTPase cycle", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SSC-2871796:r:FCERI mediated MAPK activation", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-9907900:r:Proteasome assembly", "R-SSC-179812:r:GRB2 events in EGFR signaling", "R-BTA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DDI-1268020:r:Mitochondrial protein import", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-BTA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-SCE-72086:r:mRNA Capping", "R-SSC-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-196783:r:Coenzyme A biosynthesis", "R-SPO-69052:r:Switching of origins to a post-replicative state", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-CFA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-SCE-165159:r:MTOR signalling", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-390522:r:Striated Muscle Contraction", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-9033241:r:Peroxisomal protein import", "R-CEL-4641257:r:Degradation of AXIN", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-9696273:r:RND1 GTPase cycle", "R-HSA-9833482:r:PKR-mediated signaling", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-MMU-3214815:r:HDACs deacetylate histones", "R-MMU-9020702:r:Interleukin-1 signaling", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-3247509:r:Chromatin modifying enzymes", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-BTA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-166208:r:mTORC1-mediated signalling", "R-DME-5578775:r:Ion homeostasis", "R-GGA-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-73614:r:Pyrimidine salvage", "R-GGA-156842:r:Eukaryotic Translation Elongation", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-BTA-844456:r:The NLRP3 inflammasome", "R-DDI-9648002:r:RAS processing", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-MMU-9629569:r:Protein hydroxylation", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CFA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-SCE-389359:r:CD28 dependent Vav1 pathway", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-5694530:r:Cargo concentration in the ER", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-SSC-210993:r:Tie2 Signaling", "R-GGA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-DRE-9013407:r:RHOH GTPase cycle", "R-HSA-420092:r:Glucagon-type ligand receptors", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-1296025:r:ATP sensitive Potassium channels", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-SPO-169911:r:Regulation of Apoptosis", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-SCE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-6799198:r:Complex I biogenesis", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-5678420:r:Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome", "R-DME-171007:r:p38MAPK events", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-4641257:r:Degradation of AXIN", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-428930:r:Thromboxane signalling through TP receptor", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-179812:r:GRB2 events in EGFR signaling", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-RNO-8949664:r:Processing of SMDT1", "R-HSA-167044:r:Signalling to RAS", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-190873:r:Gap junction degradation", "R-BTA-156584:r:Cytosolic sulfonation of small molecules", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CFA-9758890:r:Transport of RCbl within the body", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-RNO-5689603:r:UCH proteinases", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-DDI-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SSC-5625970:r:RHO GTPases activate KTN1", "R-RNO-9754706:r:Atorvastatin ADME", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DME-209190:r:Phosphorylation of CI", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-RNO-1266695:r:Interleukin-7 signaling", "R-CEL-6794361:r:Neurexins and neuroligins", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SSC-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-4086398:r:Ca2+ pathway", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-PFA-6798695:r:Neutrophil degranulation", "R-MMU-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-844623:r:The IPAF inflammasome", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-DRE-9648002:r:RAS processing", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-381042:r:PERK regulates gene expression", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-SCE-114608:r:Platelet degranulation", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-111458:r:Formation of apoptosome", "R-RNO-5689901:r:Metalloprotease DUBs", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-BTA-8963888:r:Chylomicron assembly", "R-RNO-5610787:r:Hedgehog 'off' state", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-GGA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-8875656:r:MET receptor recycling", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-BTA-5689901:r:Metalloprotease DUBs", "R-SPO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-SSC-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-445144:r:Signal transduction by L1", "R-BTA-156842:r:Eukaryotic Translation Elongation", "R-HSA-429947:r:Deadenylation of mRNA", "R-DME-9845576:r:Glycosphingolipid transport", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-CFA-445144:r:Signal transduction by L1", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-DME-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SCE-8951664:r:Neddylation", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-BTA-170984:r:ARMS-mediated activation", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-182971:r:EGFR downregulation", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-170968:r:Frs2-mediated activation", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DRE-169911:r:Regulation of Apoptosis", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-6811438:r:Intra-Golgi traffic", "R-SSC-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-8854214:r:TBC/RABGAPs", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-DDI-165159:r:MTOR signalling", "R-DDI-9749641:r:Aspirin ADME", "R-GGA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-DME-427359:r:SIRT1 negatively regulates rRNA expression", "R-BTA-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-DME-9907900:r:Proteasome assembly", "R-CFA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-4641257:r:Degradation of AXIN", "R-DME-111458:r:Formation of apoptosome", "R-DDI-5689603:r:UCH proteinases", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-CFA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-CEL-165159:r:MTOR signalling", "R-DME-3928664:r:Ephrin signaling", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DRE-2022854:r:Keratan sulfate biosynthesis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-SPO-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-GGA-9013420:r:RHOU GTPase cycle", "R-SSC-8963888:r:Chylomicron assembly", "R-RNO-156902:r:Peptide chain elongation", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9638482:r:Metal ion assimilation from the host", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-XTR-9013408:r:RHOG GTPase cycle", "R-SSC-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DME-1834941:r:STING mediated induction of host immune responses", "R-RNO-209563:r:Axonal growth stimulation", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8875656:r:MET receptor recycling", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DME-3247509:r:Chromatin modifying enzymes", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SPO-196025:r:Formation of annular gap junctions", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-68949:r:Orc1 removal from chromatin", "R-CFA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-9748787:r:Azathioprine ADME", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SSC-72187:r:mRNA 3'-end processing", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DDI-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-DME-3214858:r:RMTs methylate histone arginines", "R-HSA-68877:r:Mitotic Prometaphase", "R-CFA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-191859:r:snRNP Assembly", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-SCE-9013409:r:RHOJ GTPase cycle", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-SSC-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CFA-8856828:r:Clathrin-mediated endocytosis", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-MMU-189451:r:Heme biosynthesis", "R-BTA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-3359475:r:Defective MMAA causes MMA, cblA type", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-9013106:r:RHOC GTPase cycle", "R-MMU-8873719:r:RAB geranylgeranylation", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-CFA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-8873719:r:RAB geranylgeranylation", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-BTA-196757:r:Metabolism of folate and pterines", "R-RNO-9646399:r:Aggrephagy", "R-PFA-77387:r:Insulin receptor recycling", "R-PFA-75153:r:Apoptotic execution phase", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-176974:r:Unwinding of DNA", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-CFA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DME-114604:r:GPVI-mediated activation cascade", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-5632684:r:Hedgehog 'on' state", "R-DRE-9753281:r:Paracetamol ADME", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-GGA-8875656:r:MET receptor recycling", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-SSC-180336:r:SHC1 events in EGFR signaling", "R-SPO-9696273:r:RND1 GTPase cycle", "R-CFA-9013408:r:RHOG GTPase cycle", "R-DRE-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-429947:r:Deadenylation of mRNA", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-164944:r:Nef and signal transduction", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-CEL-1369062:r:ABC transporters in lipid homeostasis", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DME-1296025:r:ATP sensitive Potassium channels", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-CFA-202040:r:G-protein activation", "R-BTA-8876725:r:Protein methylation", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-9865881:r:Complex III assembly", "R-SPO-9696264:r:RND3 GTPase cycle", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-3214815:r:HDACs deacetylate histones", "R-SSC-428930:r:Thromboxane signalling through TP receptor", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-DRE-210993:r:Tie2 Signaling", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-9840373:r:Cellular response to mitochondrial stress", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-CEL-5627123:r:RHO GTPases activate PAKs", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5689603:r:UCH proteinases", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-SPO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-8951664:r:Neddylation", "R-MMU-196807:r:Nicotinate metabolism", "R-SSC-9696264:r:RND3 GTPase cycle", "R-MMU-6782135:r:Dual incision in TC-NER", "R-CEL-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-418885:r:DCC mediated attractive signaling", "R-DME-381042:r:PERK regulates gene expression", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-CFA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-5625740:r:RHO GTPases activate PKNs", "R-BTA-189483:r:Heme degradation", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-350407:r:RHO1 GTPase cycle", "R-DRE-9013408:r:RHOG GTPase cycle", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-72649:r:Translation initiation complex formation", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-156902:r:Peptide chain elongation", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-1660661:r:Sphingolipid de novo biosynthesis", "R-SPO-196757:r:Metabolism of folate and pterines", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-198203:r:PI3K/AKT activation", "R-BTA-983189:r:Kinesins", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-BTA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-SCE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-SCE-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-CFA-6807878:r:COPI-mediated anterograde transport", "R-CFA-9748787:r:Azathioprine ADME", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-72764:r:Eukaryotic Translation Termination", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-9840373:r:Cellular response to mitochondrial stress", "R-DRE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-5625970:r:RHO GTPases activate KTN1", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-XTR-354192:r:Integrin signaling", "R-HSA-611105:r:Respiratory electron transport", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DRE-4086400:r:PCP/CE pathway", "R-SCE-196757:r:Metabolism of folate and pterines", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-382556:r:ABC-family proteins mediated transport", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-422356:r:Regulation of insulin secretion", "R-GGA-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-SCE-5620912:r:Anchoring of the basal body to the plasma membrane", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-156584:r:Cytosolic sulfonation of small molecules", "R-DDI-9646399:r:Aggrephagy", "R-DRE-8951664:r:Neddylation", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-190873:r:Gap junction degradation", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9833482:r:PKR-mediated signaling", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-3899300:r:SUMOylation of transcription cofactors", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-5689901:r:Metalloprotease DUBs", "R-HSA-9629569:r:Protein hydroxylation", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DRE-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SPO-196783:r:Coenzyme A biosynthesis", "R-GGA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-CFA-9646399:r:Aggrephagy", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DDI-68949:r:Orc1 removal from chromatin", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-9013106:r:RHOC GTPase cycle", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-1169092:r:Activation of RAS in B cells", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-8876725:r:Protein methylation", "R-SSC-399997:r:Acetylcholine regulates insulin secretion", "R-SPO-73614:r:Pyrimidine salvage", "R-BTA-9758890:r:Transport of RCbl within the body", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-DME-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-983189:r:Kinesins", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-SCE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-GGA-180336:r:SHC1 events in EGFR signaling", "R-CEL-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9833110:r:RSV-host interactions", "R-GGA-933542:r:TRAF6 mediated NF-kB activation", "R-BTA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-SSC-5658442:r:Regulation of RAS by GAPs", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DME-9013407:r:RHOH GTPase cycle", "R-DME-8854214:r:TBC/RABGAPs", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-351451:r:Homologous recombination repair of replication-dependent double-strand breaks", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-2022928:r:HS-GAG biosynthesis", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DME-432395:r:Degradation of TIM", "R-DRE-9607240:r:FLT3 Signaling", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-8949664:r:Processing of SMDT1", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-SSC-8851805:r:MET activates RAS signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-69091:r:Polymerase switching", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-MMU-9770562:r:mRNA Polyadenylation", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-170670:r:Adenylate cyclase inhibitory pathway", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-CFA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-CEL-9013407:r:RHOH GTPase cycle", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-8980692:r:RHOA GTPase cycle", "R-CFA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-5610787:r:Hedgehog 'off' state", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-MMU-74217:r:Purine salvage", "R-SPO-189483:r:Heme degradation", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-CEL-69052:r:Switching of origins to a post-replicative state", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-8964058:r:HDL remodeling", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-MMU-9013419:r:RHOT2 GTPase cycle", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-5627117:r:RHO GTPases Activate ROCKs", "R-DME-432524:r:Degradation of PER", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-MMU-112043:r:PLC beta mediated events", "R-DDI-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-CFA-1169408:r:ISG15 antiviral mechanism", "R-RNO-199992:r:trans-Golgi Network Vesicle Budding", "R-DDI-8876725:r:Protein methylation", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-GGA-9607240:r:FLT3 Signaling", "R-RNO-8963888:r:Chylomicron assembly", "R-CFA-418594:r:G alpha (i) signalling events", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-DME-112043:r:PLC beta mediated events", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-SSC-9753281:r:Paracetamol ADME", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-DME-68962:r:Activation of the pre-replicative complex", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-69481:r:G2/M Checkpoints", "R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-4086398:r:Ca2+ pathway", "R-SPO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-170984:r:ARMS-mediated activation", "R-BTA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-SPO-9754706:r:Atorvastatin ADME", "R-SPO-8854214:r:TBC/RABGAPs", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-392517:r:Rap1 signalling", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-193648:r:NRAGE signals death through JNK", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DRE-9013026:r:RHOB GTPase cycle", "R-DDI-189483:r:Heme degradation", "R-DDI-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-392170:r:ADP signalling through P2Y purinoceptor 12", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DDI-73614:r:Pyrimidine salvage", "R-RNO-5632684:r:Hedgehog 'on' state", "R-SCE-5689896:r:Ovarian tumor domain proteases", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-GGA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-XTR-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-GGA-5625970:r:RHO GTPases activate KTN1", "R-DRE-72731:r:Recycling of eIF2:GDP", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-68884:r:Mitotic Telophase/Cytokinesis", "R-CEL-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-CEL-9748787:r:Azathioprine ADME", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-418594:r:G alpha (i) signalling events", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-171007:r:p38MAPK events", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-CFA-170670:r:Adenylate cyclase inhibitory pathway", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-GGA-5218921:r:VEGFR2 mediated cell proliferation", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-SPO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-DRE-9646399:r:Aggrephagy", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-189451:r:Heme biosynthesis", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DDI-983189:r:Kinesins", "R-XTR-110320:r:Translesion Synthesis by POLH", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SCE-9696270:r:RND2 GTPase cycle", "R-XTR-68949:r:Orc1 removal from chromatin", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CFA-9013418:r:RHOBTB2 GTPase cycle", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-8873719:r:RAB geranylgeranylation", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-SSC-1250347:r:SHC1 events in ERBB4 signaling", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-DDI-170968:r:Frs2-mediated activation", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-RNO-111458:r:Formation of apoptosome", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-SCE-5694530:r:Cargo concentration in the ER", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-69091:r:Polymerase switching", "R-RNO-5689877:r:Josephin domain DUBs", "R-HSA-202040:r:G-protein activation", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-BTA-9013419:r:RHOT2 GTPase cycle", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-HSA-373753:r:Nephrin family interactions", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-210993:r:Tie2 Signaling", "R-DME-437239:r:Recycling pathway of L1", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-6811438:r:Intra-Golgi traffic", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-MMU-1834941:r:STING mediated induction of host immune responses", "R-DRE-354192:r:Integrin signaling", "R-CFA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DRE-983189:r:Kinesins", "R-HSA-5635838:r:Activation of SMO", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-SPO-68867:r:Assembly of the pre-replicative complex", "R-DME-196757:r:Metabolism of folate and pterines", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9930044:r:Nuclear RNA decay", "R-RNO-189451:r:Heme biosynthesis", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-DDI-199992:r:trans-Golgi Network Vesicle Budding", "R-SPO-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SSC-189451:r:Heme biosynthesis", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DME-9748787:r:Azathioprine ADME", "R-HSA-5683678:r:Defective ABCA3 causes SMDP3", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-525793:r:Myogenesis", "R-DME-450728:r:Inhibition of actin polymerization", "R-BTA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-156842:r:Eukaryotic Translation Elongation", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9753281:r:Paracetamol ADME", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CFA-163210:r:Formation of ATP by chemiosmotic coupling", "R-DDI-8963896:r:HDL assembly", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-XTR-5358346:r:Hedgehog ligand biogenesis", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-9931953:r:Biofilm formation", "R-RNO-196757:r:Metabolism of folate and pterines", "R-RNO-182971:r:EGFR downregulation", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-CFA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-1268020:r:Mitochondrial protein import", "R-RNO-1369007:r:Mitochondrial ABC transporters", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-SPO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-DDI-1369007:r:Mitochondrial ABC transporters", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-RNO-75153:r:Apoptotic execution phase", "R-SSC-1169092:r:Activation of RAS in B cells", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-381042:r:PERK regulates gene expression", "R-HSA-114608:r:Platelet degranulation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-418885:r:DCC mediated attractive signaling", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-CFA-9696264:r:RND3 GTPase cycle", "R-RNO-354192:r:Integrin signaling", "R-CFA-399997:r:Acetylcholine regulates insulin secretion", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-SPO-9749641:r:Aspirin ADME", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-8983711:r:OAS antiviral response", "R-GGA-9648002:r:RAS processing", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-BTA-69091:r:Polymerase switching", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-418885:r:DCC mediated attractive signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-422356:r:Regulation of insulin secretion", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-SCE-156902:r:Peptide chain elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-5419276:r:Mitochondrial translation termination", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-191650:r:Regulation of gap junction activity", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SSC-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-BTA-9033241:r:Peroxisomal protein import", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-DME-193634:r:Axonal growth inhibition (RHOA activation)", "R-CEL-110312:r:Translesion synthesis by REV1", "R-CEL-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-CFA-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-SSC-186763:r:Downstream signal transduction", "R-BTA-165159:r:MTOR signalling", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-GGA-525793:r:Myogenesis", "R-GGA-352875:r:Gluconeogenesis", "R-PFA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-73614:r:Pyrimidine salvage", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SCE-354192:r:Integrin signaling", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-SPO-9758890:r:Transport of RCbl within the body", "R-SCE-9035034:r:RHOF GTPase cycle", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-BTA-5620924:r:Intraflagellar transport", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-844456:r:The NLRP3 inflammasome", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-110312:r:Translesion synthesis by REV1", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-RNO-114608:r:Platelet degranulation", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-159418:r:Recycling of bile acids and salts", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-BTA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-4086398:r:Ca2+ pathway", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-9684325:r:Maturation of replicase proteins", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-SSC-9969896:r:Lanosterol biosynthesis", "R-BTA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-1169092:r:Activation of RAS in B cells", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SPO-3371511:r:HSF1 activation", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SSC-1963640:r:GRB2 events in ERBB2 signaling", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-112412:r:SOS-mediated signalling", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-RNO-9766229:r:Degradation of CDH1", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-69091:r:Polymerase switching", "R-DME-110523:r:TOR signaling pathway", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-SSC-182971:r:EGFR downregulation", "R-DME-9013423:r:RAC3 GTPase cycle", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-68949:r:Orc1 removal from chromatin", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-DRE-8873719:r:RAB geranylgeranylation", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-SCE-9754706:r:Atorvastatin ADME", "R-MMU-445355:r:Smooth Muscle Contraction", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-69481:r:G2/M Checkpoints", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-1632852:r:Macroautophagy", "R-DME-170660:r:Adenylate cyclase activating pathway", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-DDI-9753281:r:Paracetamol ADME", "R-RNO-202040:r:G-protein activation", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-MMU-418885:r:DCC mediated attractive signaling", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-GGA-8854214:r:TBC/RABGAPs", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-BTA-112043:r:PLC beta mediated events", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CFA-8964616:r:G beta:gamma signalling through CDC42", "R-DDI-416476:r:G alpha (q) signalling events", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SSC-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-RNO-983712:r:Ion channel transport", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-5673000:r:RAF activation", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-73614:r:Pyrimidine salvage", "R-DME-2467813:r:Separation of Sister Chromatids", "R-DDI-5673000:r:RAF activation", "R-CEL-2142845:r:Hyaluronan metabolism", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DDI-445144:r:Signal transduction by L1", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-4641258:r:Degradation of DVL", "R-MMU-156842:r:Eukaryotic Translation Elongation", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-210993:r:Tie2 Signaling", "R-CEL-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SSC-114604:r:GPVI-mediated activation cascade", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-9031628:r:NGF-stimulated transcription", "R-RNO-196807:r:Nicotinate metabolism", "R-CEL-9648002:r:RAS processing", "R-DME-8876725:r:Protein methylation", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-SSC-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9927020:r:Heme assimilation", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9013026:r:RHOB GTPase cycle", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-DRE-9013419:r:RHOT2 GTPase cycle", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-68884:r:Mitotic Telophase/Cytokinesis", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-MMU-983189:r:Kinesins", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-CFA-9035034:r:RHOF GTPase cycle", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-169911:r:Regulation of Apoptosis", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-GGA-8851805:r:MET activates RAS signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-4086398:r:Ca2+ pathway", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-5689877:r:Josephin domain DUBs", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-DME-216119:r:Activation of CI", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-CEL-193648:r:NRAGE signals death through JNK", "R-DRE-75153:r:Apoptotic execution phase", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-GGA-210993:r:Tie2 Signaling", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-CFA-5625970:r:RHO GTPases activate KTN1", "R-DDI-392517:r:Rap1 signalling", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9758890:r:Transport of RCbl within the body", "R-XTR-8951664:r:Neddylation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-PFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-CEL-392170:r:ADP signalling through P2Y purinoceptor 12", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-CEL-166208:r:mTORC1-mediated signalling", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9607240:r:FLT3 Signaling", "R-SSC-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-983189:r:Kinesins", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-5627083:r:RHO GTPases regulate CFTR trafficking", "R-MMU-381042:r:PERK regulates gene expression", "R-DDI-5632684:r:Hedgehog 'on' state", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-392517:r:Rap1 signalling", "R-CFA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9753512:r:Signaling by RAS GTPase mutants", "R-HSA-5678520:r:Defective ABCB11 causes PFIC2 and BRIC2", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-PFA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5682294:r:Defective ABCA12 causes ARCI4B", "R-DDI-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-CEL-9845576:r:Glycosphingolipid transport", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-72086:r:mRNA Capping", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-BTA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-CFA-9013106:r:RHOC GTPase cycle", "R-BTA-9748787:r:Azathioprine ADME", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-CEL-1268020:r:Mitochondrial protein import", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-9707564:r:Cytoprotection by HMOX1", "R-HSA-3371511:r:HSF1 activation", "R-GGA-5654719:r:SHC-mediated cascade:FGFR4", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DRE-156584:r:Cytosolic sulfonation of small molecules", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-HSA-72086:r:mRNA Capping", "R-CFA-204005:r:COPII-mediated vesicle transport", "R-MMU-9845576:r:Glycosphingolipid transport", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-CFA-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-190873:r:Gap junction degradation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-SPO-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689603:r:UCH proteinases", "R-RNO-9013106:r:RHOC GTPase cycle", "R-SPO-9753281:r:Paracetamol ADME", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-GGA-429947:r:Deadenylation of mRNA", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-DDI-69091:r:Polymerase switching", "R-CEL-392517:r:Rap1 signalling", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-SCE-8854214:r:TBC/RABGAPs", "R-BTA-5625900:r:RHO GTPases activate CIT", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-CFA-114604:r:GPVI-mediated activation cascade", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9013408:r:RHOG GTPase cycle", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-PFA-68616:r:Assembly of the ORC complex at the origin of replication", "R-CEL-174411:r:Polymerase switching on the C-strand of the telomere", "R-CFA-9707564:r:Cytoprotection by HMOX1", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-DME-9013149:r:RAC1 GTPase cycle", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5620924:r:Intraflagellar transport", "R-SSC-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-196025:r:Formation of annular gap junctions", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-CFA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-112043:r:PLC beta mediated events", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-HSA-209563:r:Axonal growth stimulation", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-GGA-9013419:r:RHOT2 GTPase cycle", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-418597:r:G alpha (z) signalling events", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-69052:r:Switching of origins to a post-replicative state", "R-CEL-418597:r:G alpha (z) signalling events", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-SCE-196025:r:Formation of annular gap junctions", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-9629569:r:Protein hydroxylation", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-5683177:r:Defective ABCC8 can cause hypo- and hyper-glycemias", "R-GGA-389359:r:CD28 dependent Vav1 pathway", "R-DRE-180336:r:SHC1 events in EGFR signaling", "R-RNO-5358493:r:Synthesis of diphthamide-EEF2", "R-CFA-9753281:r:Paracetamol ADME", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-RNO-9757110:r:Prednisone ADME", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-SSC-5694530:r:Cargo concentration in the ER", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-SSC-5627123:r:RHO GTPases activate PAKs", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-CFA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-1268020:r:Mitochondrial protein import", "R-MMU-8983711:r:OAS antiviral response", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-9646399:r:Aggrephagy", "R-SSC-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-432626:r:Circadian Clock pathway", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-156584:r:Cytosolic sulfonation of small molecules", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-CFA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-159418:r:Recycling of bile acids and salts", "R-MMU-525793:r:Myogenesis", "R-HSA-5682910:r:LGI-ADAM interactions", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SCE-190873:r:Gap junction degradation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-9013420:r:RHOU GTPase cycle", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-8854214:r:TBC/RABGAPs", "R-DME-3928663:r:EPHA-mediated growth cone collapse", "R-DDI-169911:r:Regulation of Apoptosis", "R-CEL-176187:r:Activation of ATR in response to replication stress", "R-SSC-189483:r:Heme degradation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-CEL-156902:r:Peptide chain elongation", "R-MMU-844455:r:The NLRP1 inflammasome", "R-SSC-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-CEL-9035034:r:RHOF GTPase cycle", "R-RNO-9758890:r:Transport of RCbl within the body", "R-MMU-202040:r:G-protein activation", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-75153:r:Apoptotic execution phase", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-HSA-9635465:r:Suppression of apoptosis", "R-BTA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9610379:r:HCMV Late Events", "R-DRE-9013106:r:RHOC GTPase cycle", "R-BTA-9845576:r:Glycosphingolipid transport", "R-DME-8980692:r:RHOA GTPase cycle", "R-SSC-9013424:r:RHOV GTPase cycle", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-SSC-8949613:r:Cristae formation", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-5679001:r:Defective ABCC2 causes DJS", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-CEL-114608:r:Platelet degranulation", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-5627083:r:RHO GTPases regulate CFTR trafficking", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-354192:r:Integrin signaling", "R-RNO-77387:r:Insulin receptor recycling", "R-BTA-170968:r:Frs2-mediated activation", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DDI-9840373:r:Cellular response to mitochondrial stress", "R-CFA-5663220:r:RHO GTPases Activate Formins", "R-SPO-165159:r:MTOR signalling", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-HSA-9620244:r:Long-term potentiation", "R-BTA-5694530:r:Cargo concentration in the ER", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-5683826:r:Surfactant metabolism", "R-PFA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-196783:r:Coenzyme A biosynthesis", "R-CEL-9753281:r:Paracetamol ADME", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-SSC-171007:r:p38MAPK events", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-DME-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CFA-9706019:r:RHOBTB3 ATPase cycle", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SSC-202040:r:G-protein activation", "R-HSA-8873719:r:RAB geranylgeranylation", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-BTA-110312:r:Translesion synthesis by REV1", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-SSC-112043:r:PLC beta mediated events", "R-CFA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DDI-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-525793:r:Myogenesis", "R-CFA-389359:r:CD28 dependent Vav1 pathway", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-9648002:r:RAS processing", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-171007:r:p38MAPK events", "R-SCE-9749641:r:Aspirin ADME", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-171007:r:p38MAPK events", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-DME-5632684:r:Hedgehog 'on' state", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-SCE-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-DME-9793528:r:Ciprofloxacin ADME", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-SSC-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-159418:r:Recycling of bile acids and salts", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-SCE-9696273:r:RND1 GTPase cycle", "R-SCE-5689880:r:Ub-specific processing proteases", "R-BTA-2470946:r:Cohesin Loading onto Chromatin", "R-SSC-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-3247509:r:Chromatin modifying enzymes", "R-HSA-9670615:r:Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DDI-72764:r:Eukaryotic Translation Termination", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-SCE-193648:r:NRAGE signals death through JNK", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-73614:r:Pyrimidine salvage", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-BTA-74217:r:Purine salvage", "R-HSA-9634597:r:GPER1 signaling", "R-BTA-4086400:r:PCP/CE pathway", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-CFA-9013424:r:RHOV GTPase cycle", "R-SCE-174362:r:Transport and metabolism of PAPS", "R-CFA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5627083:r:RHO GTPases regulate CFTR trafficking", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DME-72649:r:Translation initiation complex formation", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-RNO-169911:r:Regulation of Apoptosis", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-189483:r:Heme degradation", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-9770562:r:mRNA Polyadenylation", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-912446:r:Meiotic recombination", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-1369007:r:Mitochondrial ABC transporters", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5689880:r:Ub-specific processing proteases", "R-RNO-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-GGA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-BTA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-5690338:r:Defective ABCC6 causes PXE", "R-DRE-9013424:r:RHOV GTPase cycle", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-SSC-9648002:r:RAS processing", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-170660:r:Adenylate cyclase activating pathway", "R-CFA-156584:r:Cytosolic sulfonation of small molecules", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-186763:r:Downstream signal transduction", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-196783:r:Coenzyme A biosynthesis", "R-MMU-9696273:r:RND1 GTPase cycle", "R-SCE-189483:r:Heme degradation", "R-DDI-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-5625970:r:RHO GTPases activate KTN1", "R-DDI-9707564:r:Cytoprotection by HMOX1", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-CEL-210993:r:Tie2 Signaling", "R-CEL-69091:r:Polymerase switching", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DRE-2046105:r:Linoleic acid (LA) metabolism", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-170660:r:Adenylate cyclase activating pathway", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-SSC-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-165159:r:MTOR signalling", "R-CEL-4086400:r:PCP/CE pathway", "R-GGA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-844456:r:The NLRP3 inflammasome", "R-XTR-6798695:r:Neutrophil degranulation", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CFA-8875555:r:MET activates RAP1 and RAC1", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-CFA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-DRE-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-110312:r:Translesion synthesis by REV1", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-BTA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-SSC-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-429947:r:Deadenylation of mRNA", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-CFA-5689880:r:Ub-specific processing proteases", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-5689603:r:UCH proteinases", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-75153:r:Apoptotic execution phase", "R-CFA-159418:r:Recycling of bile acids and salts", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-RNO-171007:r:p38MAPK events", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-3295583:r:TRP channels", "R-RNO-5578775:r:Ion homeostasis", "R-BTA-5625970:r:RHO GTPases activate KTN1", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-9753510:r:Signaling by RAS GAP mutants", "R-HSA-983189:r:Kinesins", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-983712:r:Ion channel transport", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-HSA-5682113:r:Defective ABCA1 causes TGD", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-XTR-9603798:r:Class I peroxisomal membrane protein import", "R-DRE-392517:r:Rap1 signalling", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-8876725:r:Protein methylation", "R-DME-189483:r:Heme degradation", "R-XTR-9013419:r:RHOT2 GTPase cycle", "R-HSA-5688399:r:Defective ABCA3 causes SMDP3", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-PFA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DDI-8854214:r:TBC/RABGAPs", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-6811438:r:Intra-Golgi traffic", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DME-216217:r:Activation of SMO", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-GGA-354192:r:Integrin signaling", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-2299718:r:Condensation of Prophase Chromosomes", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-9696270:r:RND2 GTPase cycle", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-1268020:r:Mitochondrial protein import", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DME-156842:r:Eukaryotic Translation Elongation", "R-MMU-186763:r:Downstream signal transduction", "R-CEL-389359:r:CD28 dependent Vav1 pathway", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-68962:r:Activation of the pre-replicative complex", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SSC-9793528:r:Ciprofloxacin ADME", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-GGA-375165:r:NCAM signaling for neurite out-growth", "R-DME-9969896:r:Lanosterol biosynthesis", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-5620924:r:Intraflagellar transport", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-1632852:r:Macroautophagy", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-MMU-4641258:r:Degradation of DVL", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-BTA-8980692:r:RHOA GTPase cycle", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-GGA-5673000:r:RAF activation", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-XTR-69052:r:Switching of origins to a post-replicative state", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-CFA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-190873:r:Gap junction degradation", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-1296025:r:ATP sensitive Potassium channels", "R-HSA-5678771:r:Defective ABCB4 causes PFIC3, ICP3 and GBD1", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-191650:r:Regulation of gap junction activity", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-DDI-9757110:r:Prednisone ADME", "R-DME-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-SCE-69052:r:Switching of origins to a post-replicative state", "R-BTA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-GGA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CFA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-DRE-179812:r:GRB2 events in EGFR signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-399997:r:Acetylcholine regulates insulin secretion", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9707616:r:Heme signaling", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-CFA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-SSC-416476:r:G alpha (q) signalling events", "R-XTR-73614:r:Pyrimidine salvage", "R-PFA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-GGA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-XTR-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-8980692:r:RHOA GTPase cycle", "R-SSC-9013408:r:RHOG GTPase cycle", "R-GGA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DME-428930:r:Thromboxane signalling through TP receptor", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-418594:r:G alpha (i) signalling events", "R-DME-210993:r:Tie2 Signaling", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-428930:r:Thromboxane signalling through TP receptor", "R-MMU-196757:r:Metabolism of folate and pterines", "R-RNO-170968:r:Frs2-mediated activation", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-DME-5673000:r:RAF activation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-5683826:r:Surfactant metabolism", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-5635838:r:Activation of SMO", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-373753:r:Nephrin family interactions", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SCE-445144:r:Signal transduction by L1", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-354192:r:Integrin signaling", "R-GGA-983189:r:Kinesins", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-DRE-8851805:r:MET activates RAS signaling", "R-SSC-5654699:r:SHC-mediated cascade:FGFR2", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9757110:r:Prednisone ADME", "R-XTR-8876725:r:Protein methylation", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-CFA-8873719:r:RAB geranylgeranylation", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-DDI-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CFA-189483:r:Heme degradation", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1221632:r:Meiotic synapsis", "R-PFA-199992:r:trans-Golgi Network Vesicle Budding", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-SPO-114608:r:Platelet degranulation", "R-GGA-186763:r:Downstream signal transduction", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SCE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-3928664:r:Ephrin signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-264876:r:Insulin processing", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-CFA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-CFA-8949613:r:Cristae formation", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-RNO-525793:r:Myogenesis", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-9033241:r:Peroxisomal protein import", "R-DME-9013148:r:CDC42 GTPase cycle", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5689877:r:Josephin domain DUBs", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-5626467:r:RHO GTPases activate IQGAPs", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-DRE-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-72731:r:Recycling of eIF2:GDP", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DME-114608:r:Platelet degranulation", "R-DDI-8964058:r:HDL remodeling", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-3560796:r:Defective PAPSS2 causes SEMD-PA", "R-DME-9648002:r:RAS processing", "R-RNO-72649:r:Translation initiation complex formation", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9646399:r:Aggrephagy", "R-MMU-420092:r:Glucagon-type ligand receptors", "R-GGA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-MMU-9758890:r:Transport of RCbl within the body", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DME-416482:r:G alpha (12/13) signalling events", "R-CEL-72649:r:Translation initiation complex formation", "R-CEL-170670:r:Adenylate cyclase inhibitory pathway", "R-CFA-416476:r:G alpha (q) signalling events", "R-PFA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-9031628:r:NGF-stimulated transcription", "R-RNO-8949613:r:Cristae formation", "R-BTA-77387:r:Insulin receptor recycling", "R-MMU-9757110:r:Prednisone ADME", "R-GGA-6811438:r:Intra-Golgi traffic", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DRE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-MMU-418597:r:G alpha (z) signalling events", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-PFA-917977:r:Transferrin endocytosis and recycling", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-SPO-111457:r:Release of apoptotic factors from the mitochondria", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-1266695:r:Interleukin-7 signaling", "R-SSC-8854214:r:TBC/RABGAPs", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-9770562:r:mRNA Polyadenylation", "R-DME-917937:r:Iron uptake and transport", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-2132295:r:MHC class II antigen presentation", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-GGA-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-8873719:r:RAB geranylgeranylation", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CFA-182971:r:EGFR downregulation", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-GGA-114608:r:Platelet degranulation", "R-HSA-9636569:r:Suppression of autophagy", "R-DME-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CFA-5627123:r:RHO GTPases activate PAKs", "R-DDI-68884:r:Mitotic Telophase/Cytokinesis", "R-CFA-3928664:r:Ephrin signaling", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-74217:r:Purine salvage", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-BTA-9753281:r:Paracetamol ADME", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-DME-202040:r:G-protein activation", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-5626467:r:RHO GTPases activate IQGAPs", "R-PFA-6807878:r:COPI-mediated anterograde transport", "R-DME-8951664:r:Neddylation", "R-RNO-418597:r:G alpha (z) signalling events", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-DDI-170660:r:Adenylate cyclase activating pathway", "R-SSC-9013420:r:RHOU GTPase cycle", "R-DME-6811438:r:Intra-Golgi traffic", "R-DME-156902:r:Peptide chain elongation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DME-9035034:r:RHOF GTPase cycle", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-DRE-209563:r:Axonal growth stimulation", "R-GGA-432722:r:Golgi Associated Vesicle Biogenesis", "R-XTR-196783:r:Coenzyme A biosynthesis", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5694530:r:Cargo concentration in the ER", "R-DME-110320:r:Translesion Synthesis by POLH", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-DDI-9793528:r:Ciprofloxacin ADME", "R-DME-69091:r:Polymerase switching", "R-CEL-193634:r:Axonal growth inhibition (RHOA activation)", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-445144:r:Signal transduction by L1", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-196783:r:Coenzyme A biosynthesis", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-163841:r:Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-RNO-429947:r:Deadenylation of mRNA", "R-MMU-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-GGA-1169092:r:Activation of RAS in B cells", "R-HSA-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-9754706:r:Atorvastatin ADME", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-DRE-9013425:r:RHOT1 GTPase cycle", "R-GGA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-PFA-159418:r:Recycling of bile acids and salts", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9758890:r:Transport of RCbl within the body", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5683329:r:Defective ABCD4 causes MAHCJ", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-422356:r:Regulation of insulin secretion", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DRE-1369062:r:ABC transporters in lipid homeostasis", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-174362:r:Transport and metabolism of PAPS", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-SPO-156902:r:Peptide chain elongation", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-GGA-2424491:r:DAP12 signaling", "R-HSA-112043:r:PLC beta mediated events", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-RNO-170984:r:ARMS-mediated activation", "R-SPO-5620916:r:VxPx cargo-targeting to cilium", "R-DME-166208:r:mTORC1-mediated signalling", "R-DRE-5675221:r:Negative regulation of MAPK pathway", "R-DME-9013406:r:RHOQ GTPase cycle", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-CFA-193634:r:Axonal growth inhibition (RHOA activation)", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-DDI-156902:r:Peptide chain elongation", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-RNO-72086:r:mRNA Capping", "R-HSA-8963896:r:HDL assembly", "R-SCE-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-SSC-210500:r:Glutamate Neurotransmitter Release Cycle", "R-GGA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-1369062:r:ABC transporters in lipid homeostasis", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-RNO-428930:r:Thromboxane signalling through TP receptor", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-CEL-75153:r:Apoptotic execution phase", "R-DME-2022870:r:CS-GAG biosynthesis", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-9845576:r:Glycosphingolipid transport", "R-XTR-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-418594:r:G alpha (i) signalling events", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SSC-204005:r:COPII-mediated vesicle transport", "R-DDI-1169092:r:Activation of RAS in B cells", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-156842:r:Eukaryotic Translation Elongation", "R-CEL-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-1369007:r:Mitochondrial ABC transporters", "R-DME-422356:r:Regulation of insulin secretion", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-GGA-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-8949664:r:Processing of SMDT1", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-GGA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SSC-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-RNO-156584:r:Cytosolic sulfonation of small molecules", "R-RNO-5673000:r:RAF activation", "R-DDI-2485179:r:Activation of the phototransduction cascade", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-182971:r:EGFR downregulation", "R-GGA-3371511:r:HSF1 activation", "R-HSA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-SPO-156842:r:Eukaryotic Translation Elongation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-BTA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-DDI-983712:r:Ion channel transport", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-DME-5358493:r:Synthesis of diphthamide-EEF2", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-XTR-9770562:r:mRNA Polyadenylation", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-CEL-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-1660661:r:Sphingolipid de novo biosynthesis", "R-DRE-191859:r:snRNP Assembly", "R-DME-1433557:r:Signaling by SCF-KIT", "R-MMU-917937:r:Iron uptake and transport", "R-SCE-418594:r:G alpha (i) signalling events", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-169911:r:Regulation of Apoptosis", "R-SSC-917937:r:Iron uptake and transport", "R-DRE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-SPO-198203:r:PI3K/AKT activation", "R-SCE-983189:r:Kinesins", "R-MMU-3928664:r:Ephrin signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-DDI-1632852:r:Macroautophagy", "R-MMU-68884:r:Mitotic Telophase/Cytokinesis", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-418594:r:G alpha (i) signalling events", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DRE-844456:r:The NLRP3 inflammasome", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-GGA-5654712:r:FRS-mediated FGFR4 signaling", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-9770562:r:mRNA Polyadenylation", "R-CEL-198203:r:PI3K/AKT activation", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-8875656:r:MET receptor recycling", "R-SPO-68949:r:Orc1 removal from chromatin", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-CFA-1268020:r:Mitochondrial protein import", "R-DME-69052:r:Switching of origins to a post-replicative state", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5656121:r:Translesion synthesis by POLI", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-SSC-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-2424491:r:DAP12 signaling", "R-HSA-2142845:r:Hyaluronan metabolism", "R-RNO-196025:r:Formation of annular gap junctions", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-CFA-5627117:r:RHO GTPases Activate ROCKs", "R-BTA-381042:r:PERK regulates gene expression", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-SCE-68867:r:Assembly of the pre-replicative complex", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-CEL-1369007:r:Mitochondrial ABC transporters", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-BTA-5576893:r:Phase 2 - plateau phase", "R-BTA-2485179:r:Activation of the phototransduction cascade", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-69052:r:Switching of origins to a post-replicative state", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-9629569:r:Protein hydroxylation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-DDI-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-110312:r:Translesion synthesis by REV1", "R-RNO-381042:r:PERK regulates gene expression", 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"Homologous_superfamily"}, "IPR027421": {"description": "DNA polymerase lambda lyase domain superfamily", "go_ids": [], "go_terms": [], "name": "DNA_pol_lamdba_lyase_dom_sf", "pathway_ids": ["R-BTA-5649702", "R-BTA-110373", "R-MMU-5649702", "R-MMU-5693571", "R-SPO-5693568", "R-BTA-5689880", "R-HSA-5689880", "R-DRE-110381", "R-DRE-5649702", "R-SCE-110362", "R-RNO-110362", "R-DRE-110373", "R-MMU-110381", "R-HSA-5649702", "R-DRE-110362", "R-RNO-110381", "R-DRE-6783310", "R-DRE-5693568", "R-MMU-5689880", "R-MMU-110362", "R-XTR-5693568", "R-BTA-5651801", "R-MMU-5693568", "R-HSA-5693568", "R-BTA-73930", "R-HSA-110373", "R-DRE-5689880", "R-SCE-5693568", "R-MMU-5651801", "R-HSA-110362", "R-BTA-110381", "R-HSA-5651801", "R-BTA-110362", "R-RNO-5693571", "R-HSA-6783310", "R-RNO-5689880", "R-MMU-6783310", "R-RNO-5649702", "R-MMU-110373", "R-HSA-5693571", "R-RNO-73930", "R-HSA-110381", "R-RNO-5693568", "R-RNO-5651801", "R-MMU-73930", "R-DRE-5651801", "R-DRE-73930", "R-HSA-73930", "R-RNO-110373", "R-RNO-6783310"], "pathways": ["R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-BTA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SPO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-SCE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-XTR-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-5689880:r:Ub-specific processing proteases", "R-SCE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-RNO-6783310:r:Fanconi Anemia Pathway"], "type": "Homologous_superfamily"}, "IPR027422": {"description": "ADP-ribosylation factor-binding protein GGA1-3", "go_ids": ["GO:0005802", "GO:0006886", "GO:0031267"], "go_terms": ["GO:0005802:trans-Golgi network:C", "GO:0006886:intracellular protein transport:P", "GO:0031267:small GTPase binding:F"], "name": "GGA1-3", "pathway_ids": ["R-HSA-8875656", "R-RNO-8875656", "R-HSA-8854214", "R-MMU-8875656", "R-HSA-977225"], "pathways": ["R-HSA-8875656:r:MET receptor recycling", "R-RNO-8875656:r:MET receptor recycling", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-977225:r:Amyloid fiber formation"], "type": "Family"}, "IPR027424": {"description": "Glucose Oxidase, domain 2", "go_ids": [], "go_terms": [], "name": "Glucose_Oxidase_domain_2", "pathway_ids": ["PWY-8121"], "pathways": ["PWY-8121:t:2-deoxy-D-glucose 6-phosphate degradation"], "type": "Homologous_superfamily"}, "IPR027431": {"description": "Protein kinase C, eta", "go_ids": ["GO:0004697"], "go_terms": ["GO:0004697:diacylglycerol-dependent serine/threonine kinase activity:F"], "name": "PKC_eta", "pathway_ids": ["R-MMU-114508", "R-RNO-114508", "R-HSA-418597", "R-HSA-114508"], "pathways": ["R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-418597:r:G alpha (z) signalling events", "R-HSA-114508:r:Effects of PIP2 hydrolysis"], "type": "Family"}, "IPR027432": {"description": "Deoxyguanosinetriphosphate triphosphohydrolase, C-terminal", "go_ids": [], "go_terms": [], "name": "dGTP_triphosphohydrolase_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027433": {"description": "Lipoxygenase, domain 3", "go_ids": [], "go_terms": [], "name": "Lipoxygenase_dom_3", "pathway_ids": ["PWY-5408", "PWY-5407", "PWY-6917", "PWY-8398", "PWY-5406", "PWY-8395"], "pathways": ["PWY-5408:t:9-lipoxygenase and 9-hydroperoxide lyase pathway", "PWY-5407:t:9-lipoxygenase and 9-allene oxide synthase pathway", "PWY-6917:t:vernolate biosynthesis III", "PWY-8398:t:alpha-linolenate metabolites biosynthesis", "PWY-5406:t:divinyl ether biosynthesis I", "PWY-8395:t:linoleate metabolites biosynthesis"], "type": "Homologous_superfamily"}, "IPR027434": {"description": "Homing endonuclease", "go_ids": [], "go_terms": [], "name": "Homing_endonucl", "pathway_ids": ["R-SCE-917977", "R-SCE-1222556", "R-SCE-77387", "R-SCE-9639288"], "pathways": ["R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR027435": {"description": "Stannin superfamily", "go_ids": ["GO:0016020", "GO:0005741"], "go_terms": ["GO:0016020:membrane:C", "GO:0005741:mitochondrial outer membrane:C"], "name": "Stannin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027436": {"description": "Protein kinase C, delta", "go_ids": ["GO:0004697"], "go_terms": ["GO:0004697:diacylglycerol-dependent serine/threonine kinase activity:F"], "name": "PKC_delta", "pathway_ids": ["R-RNO-877300", "R-HSA-6798695", "R-MMU-5607764", "R-RNO-111933", "R-HSA-1489509", "R-HSA-2029485", "R-RNO-450520", "R-RNO-1489509", "R-RNO-111465", "R-RNO-5668599", "R-HSA-114508", "R-RNO-2029485", "R-MMU-5668599", "R-MMU-2029485", "R-HSA-1250196", "R-RNO-114508", "R-MMU-1489509", "R-MMU-111465", "R-HSA-5607764", "R-MMU-5218921", "R-MMU-114508", "R-HSA-9755511", "R-HSA-450520", "R-MMU-450520", "R-MMU-877300", "R-MMU-111933", "R-HSA-5218921", "R-RNO-5218921", "R-RNO-5607764", "R-HSA-877300", "R-HSA-418597", "R-HSA-111933", "R-HSA-111465", "R-MMU-6798695", "R-MMU-1250196", "R-RNO-1250196", "R-HSA-5668599", "R-RNO-6798695"], "pathways": ["R-RNO-877300:r:Interferon gamma signaling", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-111933:r:Calmodulin induced events", "R-HSA-1489509:r:DAG and IP3 signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-1489509:r:DAG and IP3 signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-MMU-1489509:r:DAG and IP3 signaling", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-877300:r:Interferon gamma signaling", "R-MMU-111933:r:Calmodulin induced events", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-418597:r:G alpha (z) signalling events", "R-HSA-111933:r:Calmodulin induced events", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR027437": {"description": "Small ribosomal subunit protein uS13, C-terminal", "go_ids": [], "go_terms": [], "name": "Rbsml_uS13_C", "pathway_ids": ["R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553", "R-CFA-1799339", "R-SPO-975957", "R-CFA-72695", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-HSA-72695", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-BTA-72689", "R-MMU-9954716", "R-CFA-72702", "R-RNO-9954716", "R-SCE-6791226", "R-CFA-72706", "R-DDI-9954714", "R-BTA-72695", "R-SCE-72702", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-DRE-9954714", "R-SCE-975956", "R-SSC-9954714", "R-DDI-72695", "R-DRE-72695", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-SSC-1799339", "R-RNO-72649", "R-RNO-6791226", "R-CFA-156827", "R-DRE-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-DDI-156827", "R-SSC-72689", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-SPO-72689", "R-DDI-72702", "R-MMU-1799339", "R-CFA-9954714", "R-DDI-72689", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-CFA-975957", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-DME-72649", "R-HSA-156827", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-SSC-72695", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-SSC-72702", "R-CFA-72689", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-72695", "R-DME-975956", "R-MMU-72702", "R-DME-975957", "R-BTA-9954716", "R-CFA-9954716", "R-SPO-72649", "R-DRE-975956", "R-SPO-72695", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-HSA-9754678", "R-HSA-72649", "R-MMU-156827", "R-SSC-72649", "R-BTA-1799339", "R-BTA-9954714", "R-DRE-72649", "R-SCE-72649", "R-HSA-975957", "R-DRE-72702", "R-DME-9954714", "R-CFA-975956", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-SSC-9954716", "R-CFA-72649", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and 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"R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-72649:r:Translation initiation complex formation", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR027438": {"description": "Ecotin, C-terminal", "go_ids": [], "go_terms": [], "name": "Ecotin_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027439": {"description": "Protective antigen, heptamerisation domain", "go_ids": ["GO:0051260"], "go_terms": ["GO:0051260:protein homooligomerization:P"], "name": "PA_heptamer_dom", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Domain"}, "IPR027441": {"description": "Protective antigen, domain 4", "go_ids": [], "go_terms": [], "name": "PA_dom_4", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Homologous_superfamily"}, "IPR027442": {"description": "MAP kinase activated protein kinase, C-terminal", "go_ids": [], "go_terms": [], "name": "MAPKAPK_C", "pathway_ids": ["R-MMU-450385", "R-HSA-2142691", "R-DME-199920", "R-MMU-450302", "R-HSA-2559580", "R-CEL-450385", "R-MMU-199920", "R-MMU-6804756", "R-MMU-4420097", "R-HSA-4420097", "R-DME-2559580", "R-HSA-5357905", "R-HSA-3371453", "R-BTA-4420097", "R-HSA-450302", "R-CEL-171007", "R-HSA-171007", "R-BTA-171007", "R-MMU-3371453", "R-RNO-171007", "R-DME-3371453", "R-CEL-199920", "R-BTA-2559580", "R-RNO-4420097", "R-CEL-450302", "R-DME-450385", "R-HSA-199920", "R-DME-450302", "R-CEL-450513", "R-CEL-2559580", "R-MMU-2559580", 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of HSF1-mediated heat shock response", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-CEL-171007:r:p38MAPK events", "R-HSA-171007:r:p38MAPK events", "R-BTA-171007:r:p38MAPK events", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-171007:r:p38MAPK events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-199920:r:CREB phosphorylation", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-199920:r:CREB phosphorylation", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-DME-171007:r:p38MAPK 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{"description": "Isopenicillin N synthase-like superfamily", "go_ids": [], "go_terms": [], "name": "IPNS-like_sf", "pathway_ids": ["R-HSA-5578775", "R-HSA-2672351", "R-MMU-5578775", "R-MMU-2672351", "R-BTA-5578775", "R-HSA-9629569", "R-BTA-2672351"], "pathways": ["R-HSA-5578775:r:Ion homeostasis", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-2672351:r:Stimuli-sensing channels", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-9629569:r:Protein hydroxylation", "R-BTA-2672351:r:Stimuli-sensing channels"], "type": "Homologous_superfamily"}, "IPR027444": {"description": "DNA-binding protein H-NS-like, C-terminal domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "H-NS_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027446": {"description": "Variant surface glycoprotein C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "VSG_C_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027448": {"description": "Short tail fibre protein, C-terminal", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Short_tail_fibre_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027449": {"description": "5-keto-4-deoxyuronate isomerase, N-terminal", "go_ids": [], "go_terms": [], "name": "KduI_N", "pathway_ids": ["PWY-6507"], "pathways": ["PWY-6507:t:4-deoxy-L-threo-hex-4-enopyranuronate degradation"], "type": "Homologous_superfamily"}, "IPR027450": {"description": "Alpha-ketoglutarate-dependent dioxygenase AlkB-like", "go_ids": [], "go_terms": [], "name": "AlkB-like", "pathway_ids": ["R-MMU-73943", "R-XTR-73943", "R-HSA-73943", "R-HSA-112122", "R-DRE-73943", "R-HSA-6782315", "R-HSA-112126", "R-RNO-73943"], "pathways": ["R-MMU-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-XTR-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-HSA-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-HSA-112122:r:ALKBH2 mediated reversal of alkylation damage", "R-DRE-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-RNO-73943:r:Reversal of alkylation damage by DNA dioxygenases"], "type": "Domain"}, "IPR027451": {"description": "Arabinofuranosyltransferase, domain 1", "go_ids": [], "go_terms": [], "name": "EmbABC_dom1", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis"], "type": "Homologous_superfamily"}, "IPR027452": {"description": "Hypoxia-inducible factor 1-alpha inhibitor, domain II", "go_ids": [], "go_terms": [], "name": "FIH-1_dom_II", "pathway_ids": ["R-MMU-1234174", "R-DRE-1234174", "R-HSA-1234174"], "pathways": ["R-MMU-1234174:r:Cellular response to hypoxia", "R-DRE-1234174:r:Cellular response to hypoxia", "R-HSA-1234174:r:Cellular response to hypoxia"], "type": "Homologous_superfamily"}, "IPR027454": {"description": "Histone-like protein H-NS, N-terminal", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "Histone_HNS_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027455": {"description": "Spermine/spermidine acetyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "Sper_AcTfrase_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027458": {"description": "Pheromone alpha factor receptor, double 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"type": "Homologous_superfamily"}, "IPR027463": {"description": "Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains", "go_ids": [], "go_terms": [], "name": "AcrB_DN_DC_subdom", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638334", "R-HSA-9760173"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9760173:r:Secretion of toxins"], "type": "Homologous_superfamily"}, "IPR027464": {"description": "Ornithine decarboxylase, N-terminal", "go_ids": [], "go_terms": [], "name": "Ornithine_deCO2ase_N", "pathway_ids": ["PWY-46"], "pathways": ["PWY-46:t:putrescine biosynthesis III"], "type": "Homologous_superfamily"}, "IPR027465": {"description": "Proteinase inhibitor I35b (TIMP), C-terminal", "go_ids": [], "go_terms": [], "name": "TIMP_C", "pathway_ids": ["R-MMU-9839383", "R-HSA-6798695", "R-CFA-1592389", "R-RNO-1592389", "R-MMU-1592389", "R-RNO-9839383", "R-HSA-9839383", "R-HSA-1592389", "R-GGA-114608", "R-HSA-6785807", "R-MMU-8957275", "R-RNO-114608", "R-RNO-381426", "R-HSA-114608", "R-RNO-8957275", "R-MMU-381426", "R-CFA-9839383", "R-MMU-6798695", "R-HSA-8957275", "R-CFA-6798695", "R-HSA-6783783", "R-HSA-381426", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-MMU-9839383:r:TGFBR3 PTM regulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-GGA-114608:r:Platelet degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding 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"R-HSA-5083633", "R-HSA-3000171", "R-HSA-9913351", "R-HSA-9619665", "R-HSA-9010553", "R-MMU-9939291", "R-MMU-9010553", "R-CFA-9913351", "R-HSA-8932506", "R-MMU-9913351", "R-MMU-8932504", "R-CFA-9010553", "R-CFA-8932506", "R-CFA-8932504", "R-HSA-9939291", "R-HSA-5083629", "R-HSA-5083628", "R-CFA-8932505", "R-MMU-8932506"], "pathways": ["R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-CFA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-5083633:r:Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-CFA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-8932506:r:DAG1 core M1 glycosylations", "R-CFA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-5083629:r:Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "R-HSA-5083628:r:Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "R-CFA-8932505:r:DAG1 core M3 glycosylations", "R-MMU-8932506:r:DAG1 core M1 glycosylations"], "type": "Homologous_superfamily"}, "IPR027469": {"description": "Cation efflux transmembrane domain superfamily", "go_ids": [], "go_terms": [], "name": "Cation_efflux_TMD_sf", "pathway_ids": ["R-RNO-264876", "R-SCE-435368", "R-HSA-264876", "R-SPO-264876", "R-MMU-425410", "R-CEL-425410", "R-XTR-435368", "R-DDI-264876", "R-RNO-435368", "R-SPO-435368", "R-SCE-425410", "R-MMU-435368", "R-CEL-435368", "R-XTR-264876", "R-MMU-264876", "R-DDI-435368", "R-DRE-264876", "R-HSA-425410", "R-SPO-425410", "R-DDI-425410", "R-DRE-435368", "R-SCE-264876", "R-HSA-435368"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-SCE-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-HSA-264876:r:Insulin processing", "R-SPO-264876:r:Insulin processing", "R-MMU-425410:r:Metal ion SLC transporters", "R-CEL-425410:r:Metal ion SLC transporters", "R-XTR-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-DDI-264876:r:Insulin processing", "R-RNO-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SPO-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SCE-425410:r:Metal ion SLC transporters", "R-MMU-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-CEL-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-XTR-264876:r:Insulin processing", "R-MMU-264876:r:Insulin processing", "R-DDI-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-DRE-264876:r:Insulin processing", "R-HSA-425410:r:Metal ion SLC transporters", "R-SPO-425410:r:Metal ion SLC transporters", "R-DDI-425410:r:Metal ion SLC transporters", "R-DRE-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SCE-264876:r:Insulin processing", "R-HSA-435368:r:Zinc efflux and compartmentalization by the SLC30 family"], "type": "Homologous_superfamily"}, "IPR027470": {"description": "Cation efflux protein, cytoplasmic domain", "go_ids": [], "go_terms": [], "name": "Cation_efflux_CTD", "pathway_ids": ["R-RNO-264876", "R-SCE-435368", "R-HSA-264876", "R-MMU-425410", "R-CEL-425410", "R-XTR-435368", "R-DDI-264876", "R-RNO-435368", "R-SPO-435368", "R-SCE-425410", "R-MMU-435368", "R-CEL-435368", "R-XTR-264876", "R-MMU-264876", "R-DDI-435368", "R-HSA-425410", "R-SPO-425410", "R-DDI-425410", "R-HSA-435368"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-SCE-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-HSA-264876:r:Insulin processing", "R-MMU-425410:r:Metal ion SLC transporters", "R-CEL-425410:r:Metal ion SLC transporters", "R-XTR-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-DDI-264876:r:Insulin processing", "R-RNO-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SPO-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SCE-425410:r:Metal ion SLC transporters", "R-MMU-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-CEL-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-XTR-264876:r:Insulin processing", "R-MMU-264876:r:Insulin processing", "R-DDI-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-HSA-425410:r:Metal ion SLC transporters", "R-SPO-425410:r:Metal ion SLC transporters", "R-DDI-425410:r:Metal ion SLC transporters", "R-HSA-435368:r:Zinc efflux and compartmentalization by the SLC30 family"], "type": "Domain"}, "IPR027471": {"description": "YbeD-like domain superfamily", "go_ids": [], "go_terms": [], "name": "YbeD-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027472": {"description": "Pput2613-like deaminase", "go_ids": [], "go_terms": [], "name": "Pput2613-NH3ase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027473": {"description": "L-asparaginase, C-terminal", "go_ids": [], "go_terms": [], "name": "L-asparaginase_C", "pathway_ids": ["R-HSA-8963693", "R-RNO-8963693", "R-MMU-8963693"], "pathways": ["R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-MMU-8963693:r:Aspartate and asparagine metabolism"], "type": "Homologous_superfamily"}, "IPR027474": {"description": "L-asparaginase, N-terminal", "go_ids": [], "go_terms": [], "name": "L-asparaginase_N", "pathway_ids": ["R-HSA-8963693", "R-RNO-8963693", "R-MMU-8963693"], "pathways": ["R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-MMU-8963693:r:Aspartate and asparagine metabolism"], "type": "Domain"}, "IPR027476": {"description": "D-aminopeptidase, N-terminal", "go_ids": [], "go_terms": [], "name": "DppA_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR027477": {"description": "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily", "go_ids": [], "go_terms": [], "name": "Succ_DH/fumarate_Rdtase_cat_sf", "pathway_ids": ["R-HSA-9854311", "R-SPO-9854311", "R-DRE-9854311", "R-GGA-372987", "R-SSC-9854311", "R-DRE-71403", "R-HSA-611105", "R-RNO-9854311", "R-DME-9854311", "R-SSC-71403", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-CEL-9854311", "R-MMU-71403", "R-SCE-71403", "R-XTR-9854311", "R-DME-71403", "R-DDI-9854311", "R-DDI-71403", "R-RNO-71403", "R-XTR-71403", "R-HSA-71403", "R-SCE-9854311"], "pathways": ["R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Homologous_superfamily"}, "IPR027478": {"description": "Murein tetrapeptide carboxypeptidase, N-terminal", "go_ids": [], "go_terms": [], "name": "LdcA_N", "pathway_ids": ["PWY-6470", "PWY-5707", "PWY-5706", "PWY-7614"], "pathways": ["PWY-6470:t:peptidoglycan biosynthesis V (beta-lactam resistance)", "PWY-5707:t:propanethial S-oxide biosynthesis", "PWY-5706:t:alliin metabolism", "PWY-7614:t:methiin metabolism"], "type": "Homologous_superfamily"}, "IPR027479": {"description": "S-Me-THD, 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"R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Homologous_superfamily"}, "IPR027481": {"description": "HIV-1 Nef protein, core domain superfamily", "go_ids": [], "go_terms": [], "name": "HIV-1_Nef_core_sf", "pathway_ids": ["R-HSA-173107", "R-HSA-164940", "R-HSA-164944", "R-HSA-167590", "R-HSA-175474", "R-HSA-164939", "R-HSA-162585", "R-HSA-162588", "R-HSA-162599", "R-HSA-182218"], "pathways": ["R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-HSA-164944:r:Nef and signal transduction", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-164939:r:Nef mediated downregulation of CD28 cell surface expression", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-162599:r:Late Phase of HIV Life Cycle", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Homologous_superfamily"}, "IPR027482": {"description": "Sec1-like, domain 2", "go_ids": [], "go_terms": [], "name": "Sec1-like_dom2", "pathway_ids": ["R-MMU-204005", "R-DDI-114516", "R-MMU-6811438", "R-CEL-181430", "R-MMU-181430", "R-CEL-114516", "R-SCE-204005", "R-SCE-114608", "R-DDI-114608", "R-CEL-888590", "R-RNO-212676", "R-SCE-8980692", "R-RNO-983231", "R-CEL-264642", "R-HSA-210500", "R-MMU-449836", "R-BTA-181430", "R-HSA-181430", "R-DDI-204005", "R-DME-210500", "R-DME-8980692", "R-DME-114608", "R-RNO-6811438", "R-HSA-983231", "R-CEL-114608", "R-HSA-264642", "R-BTA-888590", "R-CEL-212676", "R-DDI-6811438", "R-MMU-264642", "R-SPO-8980692", "R-HSA-204005", "R-HSA-8980692", "R-DME-181430", "R-RNO-264642", "R-HSA-1445148", "R-RNO-181429", "R-SCE-983231", "R-HSA-212676", "R-MMU-114608", "R-DME-204005", "R-HSA-114516", "R-HSA-449836", "R-BTA-210500", "R-HSA-6811438", "R-MMU-8980692", "R-RNO-8980692", "R-CEL-210500", "R-MMU-983231", "R-DME-264642", "R-SPO-114608", "R-HSA-6794361", "R-RNO-114608", "R-DME-888590", "R-DME-449836", "R-HSA-181429", "R-SPO-114516", "R-HSA-114608", "R-HSA-9754560", "R-HSA-9636383", "R-BTA-212676", "R-CEL-181429", "R-DME-181429", "R-BTA-264642", "R-DDI-449836", "R-MMU-212676", "R-MMU-114516", "R-SCE-114516", "R-MMU-888590", "R-RNO-210500", "R-RNO-181430", "R-MMU-210500", "R-SPO-204005", "R-MMU-181429", "R-CEL-449836", "R-DME-212676", "R-RNO-204005", "R-HSA-888590", "R-DME-114516", "R-BTA-181429", "R-RNO-888590", "R-RNO-449836", "R-HSA-422356"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-MMU-6811438:r:Intra-Golgi traffic", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-114608:r:Platelet degranulation", "R-DDI-114608:r:Platelet degranulation", "R-CEL-888590:r:GABA synthesis, 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degradation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DDI-6811438:r:Intra-Golgi traffic", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-114608:r:Platelet degranulation", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-HSA-449836:r:Other interleukin signaling", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SPO-114608:r:Platelet degranulation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-114608:r:Platelet degranulation", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-449836:r:Other interleukin signaling", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DDI-449836:r:Other interleukin signaling", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-449836:r:Other interleukin signaling", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-114516:r:Disinhibition of SNARE formation", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Homologous_superfamily"}, "IPR027483": {"description": "Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PInositol-4-P-4/5-kinase_C_sf", "pathway_ids": ["R-MMU-8856828", "R-MMU-8847453", "R-BTA-1660499", "R-HSA-1660517", "R-SCE-8856828", "R-MMU-1660517", "R-SPO-6811555", "R-MMU-6811558", "R-HSA-8856828", "R-DDI-6811558", "R-DDI-1660499", "R-MMU-1660516", "R-MMU-201688", "R-SPO-1660499", "R-HSA-1660499", "R-DME-6811558", "R-SCE-6811558", "R-PFA-8847453", "R-DDI-8847453", "R-RNO-6811558", "R-RNO-6811555", "R-DRE-6811558", "R-BTA-6811558", "R-DME-1660499", "R-SCE-8847453", "R-HSA-399955", "R-DDI-8856828", "R-MMU-1660514", "R-RNO-8856828", "R-DME-8856828", "R-RNO-9768727", "R-PFA-6811555", "R-SPO-8847453", "R-DRE-8847453", "R-SPO-6811558", "R-HSA-201688", "R-MMU-399955", "R-PFA-8856828", "R-SCE-1660499", "R-DME-399955", 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["GO:0007005:mitochondrion organization:P", "GO:0032865:ERMES complex:C"], "name": "Mdm10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027541": {"description": "Arsenical pump-driving ATPase", "go_ids": ["GO:0015446", "GO:0071722", "GO:0005524", "GO:0016887"], "go_terms": ["GO:0015446:ATPase-coupled arsenite transmembrane transporter activity:F", "GO:0071722:detoxification of arsenic-containing substance:P", "GO:0005524:ATP binding:F", "GO:0016887:ATP hydrolysis activity:F"], "name": "Ars_ATPase", "pathway_ids": ["PWY-6421", "PWY-8101", "PWY-8260", "PWY-8264"], "pathways": ["PWY-6421:t:arsenate detoxification IV (mycothiol)", "PWY-8101:t:arsenate detoxification II", "PWY-8260:t:roxarsone degradation I", "PWY-8264:t:arsenate detoxification I"], "type": "Family"}, "IPR027548": {"description": "Small ribosomal subunit protein eS19, archaea", "go_ids": ["GO:0005840", "GO:0003735", "GO:0006412"], "go_terms": ["GO:0005840:ribosome:C", "GO:0003735:structural constituent of ribosome:F", "GO:0006412:translation:P"], "name": "Ribosomal_eS19_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027550": {"description": "MSEP-CTERM protein", "go_ids": [], "go_terms": [], "name": "MSEP-CTERM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027551": {"description": "Exosortase K", "go_ids": [], "go_terms": [], "name": "Exosort_XrtK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027552": {"description": "CGP-CTERM protein-sorting domain", "go_ids": [], "go_terms": [], "name": "CGP_CTERM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027553": {"description": "Eight-cysteine-cluster domain", "go_ids": [], "go_terms": [], "name": "Heavy_Cys", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027554": {"description": "Methyltransferase, Rta_06860 family", "go_ids": [], "go_terms": [], "name": "Meth_Rta_06860", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027555": {"description": "tRNA (Mo5U34)-methyltransferase-like", "go_ids": [], "go_terms": [], "name": "Mo5U34_MeTrfas-like", "pathway_ids": ["PWY-4681", "PWY-8382", "PWY-8389", "PWY-7529", "PWY-8243", "PWY-7998", "PWY-6262", "PWY-8442", "PWY-5802", "PWY-7493", "PWY-5815", "PWY-5817", "PWY-8084", "PWY-7540", "PWY-7520", "PWY-7555", "PWY-8388", "PWY-6659", "PWY-7407", "PWY-7599", "PWY-7405", "PWY-7719", "PWY-6681", "PWY-8461", "PWY-7906", "PWY-7543", "PWY-8253", "PWY-7372", "PWY-8083", "PWY-5979", "PWY-5893", "PWY-7603", "PWY-6403", "PWY-7532", "PWY-6936", "PWY-7605", "PWY-5816", "PWY-7708", "PWY-7659", "PWY-4502", "PWY-7572", "PWY-8080"], "pathways": ["PWY-4681:t:kievitone biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-8389:t:penigequinolone biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-7998:t:menaquinol-4 biosynthesis II", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-8442:t:hyperxanthone E biosynthesis", "PWY-5802:t:alizarin biosynthesis", "PWY-7493:t:paxilline and diprenylpaxilline biosynthesis", "PWY-5815:t:rubber biosynthesis", "PWY-5817:t:dodecaprenyl diphosphate biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7540:t:aflatrem biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-8388:t:aspoquinolone biosynthesis", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-6681:t:neurosporaxanthin biosynthesis", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7906:t:rhizobitoxine biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-8083:t:domoic acid biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-5893:t:tridecaprenyl diphosphate biosynthesis", "PWY-7603:t:stephacidin A biosynthesis", "PWY-6403:t:carrageenan biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-7605:t:roquefortine C biosynthesis", "PWY-5816:t:all trans undecaprenyl diphosphate biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-4502:t:wighteone and luteone biosynthesis", "PWY-7572:t:lolitrem B biosynthesis", "PWY-8080:t:kainate biosynthesis"], "type": "Family"}, "IPR027556": {"description": "CGP-CTERM domain protein", "go_ids": [], "go_terms": [], "name": "Heavy_Cys_CGP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027557": {"description": "Archaeosortase ArtF", "go_ids": [], "go_terms": [], "name": "Archaeo_ArtF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027558": {"description": "Prepilin-type processing-associated H-X9-DG C-terminal domain", "go_ids": [], "go_terms": [], "name": "Pre_pil_HX9DG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027559": {"description": "B12-binding domain/radical SAM domain protein, rhizo-twelve system", "go_ids": [], "go_terms": [], "name": "B12_rSAM_oligo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027560": {"description": "PEFG-CTERM domain", "go_ids": [], "go_terms": [], "name": "PEFG-CTERM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027561": {"description": "Thaumarchaeosortase", "go_ids": [], "go_terms": [], "name": "Thauma_sortase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027562": {"description": "Histidine-histamine antiporter", "go_ids": [], "go_terms": [], "name": "His_histam_anti", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027563": {"description": "Pyridoxal-phosphate-dependent protein EgtE", "go_ids": [], "go_terms": [], "name": "EgtE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027564": {"description": "Hopanoid C-3 methylase HpnR", "go_ids": [], "go_terms": [], "name": "HpnR_B12_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027565": {"description": "Cupin fold metalloprotein, WbuC family", "go_ids": [], "go_terms": [], "name": "Cupin_WbuC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027566": {"description": "Putrescine transporter PotE", "go_ids": ["GO:0015847", "GO:0015822", "GO:0015496"], "go_terms": ["GO:0015847:putrescine transport:P", "GO:0015822:ornithine transport:P", "GO:0015496:putrescine:ornithine antiporter activity:F"], "name": "Symport/antiport_PotE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027567": {"description": "Exosortase XrtM", "go_ids": [], "go_terms": [], "name": "Exosort_XrtM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027568": {"description": "Ornithine decarboxylase SpeF", "go_ids": ["GO:0004586"], "go_terms": ["GO:0004586:ornithine decarboxylase activity:F"], "name": "ODC_inducible", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027569": {"description": "GeoRSP system PqqD family protein", "go_ids": [], "go_terms": [], "name": "Geo_PqqD_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027570": {"description": "GeoRSP system radical SAM/SPASM protein", "go_ids": [], "go_terms": [], "name": "GeoRSP_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027571": {"description": "GeoRSP system SPASM domain protein", "go_ids": [], "go_terms": [], "name": "GeoRSP_SPASM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027572": {"description": "4-aminobenzoate synthase", "go_ids": [], "go_terms": [], "name": "Fol-rel_CADD", "pathway_ids": ["PWY-7854", "PWY-8281"], "pathways": ["PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-8281:t:4-aminobenzoate biosynthesis III"], "type": "Family"}, "IPR027573": {"description": "Methyltransferase, FxLD system", "go_ids": [], "go_terms": [], "name": "Methyltran_FxLD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027574": {"description": "Thiaminase II", "go_ids": ["GO:0050334", "GO:0006772"], "go_terms": ["GO:0050334:thiaminase activity:F", "GO:0006772:thiamine metabolic process:P"], "name": "Thiaminase_II", "pathway_ids": ["PWY-6899", "PWY-7356"], "pathways": ["PWY-6899:t:base-degraded thiamine salvage", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)"], "type": "Family"}, "IPR027575": {"description": "FxLD family lantipeptide", "go_ids": [], "go_terms": [], "name": "LD_lanti_pre", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027576": {"description": "Choice-of-anchor C domain", "go_ids": [], "go_terms": [], "name": "Choice_anch_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027577": {"description": "5-histidylcysteine sulfoxide synthase", "go_ids": [], "go_terms": [], "name": "OvoA_Nterm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027578": {"description": "Proline-rich tail region repeat", "go_ids": [], "go_terms": [], "name": "ProTail_Rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR027579": {"description": "Surface protein repeat SSSPR-51", "go_ids": [], "go_terms": [], "name": "SSSPR51_Rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR027580": {"description": "EXLDI protein", "go_ids": [], "go_terms": [], "name": "EXLDI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027581": {"description": "ACGX-repeat peptide", "go_ids": [], "go_terms": [], "name": "Target_ACGX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027582": {"description": "Amanitin/phalloidin toxin", "go_ids": [], "go_terms": [], "name": "Amanitin/phalloidin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027583": {"description": "Radical SAM/SPASM domain protein, ACGX system", "go_ids": [], "go_terms": [], "name": "rSAM_ACGX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027584": {"description": "Entry exclusion lipoprotein TrbK", "go_ids": [], "go_terms": [], "name": "TrbK_RP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027585": {"description": "Pantocin A family RiPP precursor", "go_ids": [], "go_terms": [], "name": "Pantocin_A_RiPP_pre", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027586": {"description": "Putative radical SAM/SPASM metalloenzyme maturase", "go_ids": [], "go_terms": [], "name": "rSAM_metal_mat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027587": {"description": "Conjugative transfer region protein TrbK", "go_ids": [], "go_terms": [], "name": "TrbK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027588": {"description": "XXXCH domain family", "go_ids": [], "go_terms": [], "name": "XXXCH_dom_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027589": {"description": "Choice-of-anchor B domain", "go_ids": [], "go_terms": [], "name": "Choice_anch_B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027590": {"description": "MSMEG_3727, PQQ-associated", "go_ids": [], "go_terms": [], "name": "PQQ_MSMEG_3727", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027591": {"description": "CofD-related protein, GAK system", "go_ids": [], "go_terms": [], "name": "CofD-rel_GAK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027592": {"description": "ATP-grasp enzyme, GAK system", "go_ids": [], "go_terms": [], "name": "ATP-grasp_GAK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027593": {"description": "Aromatic cluster surface protein", "go_ids": [], "go_terms": [], "name": "Aro_clust", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027594": {"description": "Methanogenesis multiheme c-type cytochrome", "go_ids": [], "go_terms": [], "name": "Methanoheme_cyt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027595": {"description": "Conserved hypothetical protein CHP04338", "go_ids": [], "go_terms": [], "name": "CHP04338", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027596": {"description": "AmmeMemoRadiSam system radical SAM enzyme", "go_ids": [], "go_terms": [], "name": "AmmeMemoSam_rS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027597": {"description": "HprK-related kinase B", "go_ids": [], "go_terms": [], "name": "HprK-rel_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027598": {"description": "Amphi-Trp domain", "go_ids": [], "go_terms": [], "name": "Amphi-Trp_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027599": {"description": "PqqD family protein, HPr-rel-A system", "go_ids": [], "go_terms": [], "name": "PqqD-rel_X", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027600": {"description": "HprK-related kinase A", "go_ids": [], "go_terms": [], "name": "HprK-rel_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027601": {"description": "Cys-rich peptide, Clo7bot family", "go_ids": [], "go_terms": [], "name": "Clo7Bot_mod_Cys", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027602": {"description": "Poly-gamma-glutamate system protein", "go_ids": [], "go_terms": [], "name": "PGA_system", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027603": {"description": "LIC12162 family transferase", "go_ids": [], "go_terms": [], "name": "LIC12162", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027604": {"description": "Tungsten cofactor oxidoreducase radical SAM maturase", "go_ids": [], "go_terms": [], "name": "W_rSAM_matur", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027605": {"description": "Putative ornithine decarboxylase, Lactobacillus", "go_ids": [], "go_terms": [], "name": "Lacto_ODC_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027606": {"description": "Surface protein repeat Ser-Ala-175", "go_ids": [], "go_terms": [], "name": "SerAla_Lrha_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR027607": {"description": "SEC10/PgrA surface exclusion domain", "go_ids": [], "go_terms": [], "name": "Surf_Exclu_SEC10/PgrA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027608": {"description": "Spirochetes SPASM protein", "go_ids": [], "go_terms": [], "name": "Spiro_SPASM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027609": {"description": "7-carboxy-7-deazaguanine synthase, proteobacteria", "go_ids": [], "go_terms": [], "name": "rSAM_QueE_proteobac", "pathway_ids": ["PWY-6703"], "pathways": ["PWY-6703:t:preQ0 biosynthesis"], "type": "Family"}, "IPR027610": {"description": "Sporadic carbohydrate cluster protein LIC12192", "go_ids": [], "go_terms": [], "name": "SpoChClust_LIC12192", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027611": {"description": "Sporadic carbohydrate cluster 2-oxoglutarate-Fe(II) oxygenase", "go_ids": [], "go_terms": [], "name": "SpoChClust_oxygenase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027612": {"description": "Putative methyltransferase, LIC12133 family", "go_ids": [], "go_terms": [], "name": "Put_MTase_LIC12133", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027613": {"description": "Surface carbohydrate biosynthesis protein LIC13510", "go_ids": [], "go_terms": [], "name": "O_ant_LIC13510", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027614": {"description": "Predicted outer membrane protein, Leptospiraceae", "go_ids": [], "go_terms": [], "name": "OMP_Lepto", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027615": {"description": "Putative TOMM peptide", "go_ids": [], "go_terms": [], "name": "TOMM_nitrile_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027616": {"description": "CRISPR-associated protein Cas4, PREFRAN subtype", "go_ids": [], "go_terms": [], "name": "Cas4_PREFRAN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027617": {"description": "CRISPR-associated endonuclease Cas1, PREFRAN subtype", "go_ids": ["GO:0046872", "GO:0004520", "GO:0043571"], "go_terms": ["GO:0046872:metal ion binding:F", "GO:0004520:DNA endonuclease activity:F", "GO:0043571:maintenance of CRISPR repeat elements:P"], "name": "Cas1_PREFRAN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027618": {"description": "Beta-propeller repeat, Msarc-type", "go_ids": [], "go_terms": [], "name": "Beta_prop_Msarc", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR027619": {"description": "C-S lyase, PatB-like", "go_ids": [], "go_terms": [], "name": "C-S_lyase_PatB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027620": {"description": "CRISPR-associated endonuclease Cas12a", "go_ids": [], "go_terms": [], "name": "Cas12a", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027621": {"description": "Putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE", "go_ids": [], "go_terms": [], "name": "rSAM_QueE_gams", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027622": {"description": "Radical SAM/SPASM domain-containing Clo7bot peptide maturase", "go_ids": [], "go_terms": [], "name": "rSAM_Clo7bot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027623": {"description": "AmmeMemoRadiSam system protein A", "go_ids": [], "go_terms": [], "name": "AmmeMemoSam_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027624": {"description": "Thiazole/oxazole-forming peptide maturase, SagD family component", "go_ids": [], "go_terms": [], "name": "TOMM_cyclo_SagD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027625": {"description": "Putative 4-mercaptohistidine N1-methyltranferase, OvoA C-terminal domain", "go_ids": [], "go_terms": [], "name": "OvoA_Cterm", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027626": {"description": "Pseudo-rSAM protein/SPASM domain protein", "go_ids": [], "go_terms": [], "name": "Pseudo_SAM_Halo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027627": {"description": "Putative glycosyltransferase", "go_ids": [], "go_terms": [], "name": "Glycosyltransferase_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027628": {"description": "Conjugal transfer/type IV secretion protein DotA/TraY", "go_ids": [], "go_terms": [], "name": "DotA_TraY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027629": {"description": "Putative protein phosphatase DevT-like", "go_ids": [], "go_terms": [], "name": "DevT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027631": {"description": "Monomeric [FeFe] hydrogenase", "go_ids": [], "go_terms": [], "name": "Mono_FeFe_hydrog", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027632": {"description": "Type 2 lantibiotic, A2 family", "go_ids": ["GO:0050830"], "go_terms": ["GO:0050830:defense response to Gram-positive bacterium:P"], "name": "Lant_2_A2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027633": {"description": "Putative heme D1 biosynthesis radical SAM protein NirJ2", "go_ids": [], "go_terms": [], "name": "rSAM_NirJ2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027635": {"description": "Type 2 lantibiotic, leader peptide domain", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense response to bacterium:P"], "name": "Lantibiotic2_lead_pep_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027636": {"description": "Glucan-binding repeat", "go_ids": [], "go_terms": [], "name": "Glucan-bd_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR027639": {"description": "ComB, archaeal", "go_ids": ["GO:0019295", "GO:0050532"], "go_terms": ["GO:0019295:coenzyme M biosynthetic process:P", "GO:0050532:2-phosphosulfolactate phosphatase activity:F"], "name": "ComB_archaeal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027640": {"description": "Kinesin-like protein", "go_ids": ["GO:0003777", "GO:0007018"], "go_terms": ["GO:0003777:microtubule motor activity:F", "GO:0007018:microtubule-based movement:P"], "name": "Kinesin-like_fam", "pathway_ids": ["R-DME-209360", "R-RNO-2132295", "R-RNO-6811434", "R-HSA-2500257", "R-MMU-437239", "R-RNO-68877", "R-DDI-5610787", "R-HSA-390471", "R-MMU-68884", "R-DDI-983189", "R-MMU-5625970", "R-HSA-5632684", "R-DDI-68884", "R-XTR-983189", "R-HSA-983189", "R-HSA-5663220", "R-RNO-9648025", "R-HSA-9725370", "R-HSA-5625970", "R-GGA-6811434", "R-MMU-5632684", "R-RNO-5625970", "R-RNO-983189", "R-DME-216217", "R-HSA-264876", "R-MMU-2467813", "R-DRE-5632684", "R-MMU-68877", "R-HSA-6811434", "R-XTR-6811434", "R-SPO-9696273", "R-MMU-5610787", "R-MMU-5620912", "R-MMU-5620924", "R-MMU-6811434", "R-HSA-5620924", "R-MMU-141444", "R-MMU-5635838", "R-HSA-437239", "R-HSA-141444", "R-HSA-9648025", "R-DME-68884", "R-CEL-5620924", "R-RNO-5663220", "R-CEL-983189", "R-DRE-983189", "R-HSA-68884", "R-HSA-5635838", "R-HSA-1445148", "R-RNO-2467813", "R-RNO-5620924", "R-GGA-983189", "R-HSA-9609736", "R-MMU-5663220", "R-RNO-141444", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-983189", "R-DME-209338", "R-DME-209214", "R-DME-983189", "R-SPO-68884", "R-HSA-68877", "R-HSA-5610787", "R-DME-209159", "R-MMU-2132295", "R-MMU-9648025", "R-HSA-5620912", "R-DME-216119", "R-DME-209190", "R-MMU-2500257"], "pathways": ["R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-68877:r:Mitotic Prometaphase", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-68884:r:Mitotic Telophase/Cytokinesis", "R-DDI-983189:r:Kinesins", "R-MMU-5625970:r:RHO GTPases activate KTN1", "R-HSA-5632684:r:Hedgehog 'on' state", 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"R-MMU-5620924:r:Intraflagellar transport", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5635838:r:Activation of SMO", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-68884:r:Mitotic Telophase/Cytokinesis", "R-CEL-5620924:r:Intraflagellar transport", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-983189:r:Kinesins", "R-DRE-983189:r:Kinesins", "R-HSA-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-5635838:r:Activation of SMO", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-GGA-983189:r:Kinesins", "R-HSA-9609736:r:Assembly and 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"R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR027659": {"description": "Beta-sarcoglycan", "go_ids": ["GO:0007517", "GO:0016012", "GO:0016020"], "go_terms": ["GO:0007517:muscle organ development:P", "GO:0016012:sarcoglycan complex:C", "GO:0016020:membrane:C"], "name": "Sgcb", "pathway_ids": ["R-MMU-9913351", "R-BTA-9913351", "R-HSA-9913351"], "pathways": ["R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-BTA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Family"}, "IPR027681": {"description": "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar", "go_ids": [], "go_terms": [], "name": "IRSp53/IRTKS/Pinkbar", "pathway_ids": ["R-BTA-2029482", "R-HSA-5663213", "R-MMU-9035034", "R-HSA-9664422", "R-RNO-9035034", "R-RNO-9013149", "R-HSA-2029482", "R-MMU-4420097", "R-MMU-9013404", "R-MMU-2029482", "R-RNO-2029482", "R-BTA-9013423", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013423", "R-RNO-5663213", "R-HSA-9013149", "R-MMU-5663213", "R-BTA-5663213", "R-HSA-9013404", "R-HSA-4420097", "R-DRE-9035034", "R-HSA-9035034", "R-HSA-9013148", "R-RNO-9013404", "R-MMU-9013149", "R-RNO-4420097"], "pathways": ["R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-9035034:r:RHOF GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Family"}, "IPR027684": {"description": "Tubulin-specific chaperone C", "go_ids": ["GO:0007023"], "go_terms": ["GO:0007023:post-chaperonin tubulin folding pathway:P"], "name": "TBCC", "pathway_ids": ["R-HSA-389977"], "pathways": ["R-HSA-389977:r:Post-chaperonin tubulin folding pathway"], "type": "Family"}, "IPR027685": {"description": "Shroom family", "go_ids": ["GO:0051015"], "go_terms": ["GO:0051015:actin filament binding:F"], "name": "Shroom_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027702": {"description": "Syncoilin", "go_ids": ["GO:0005882"], "go_terms": ["GO:0005882:intermediate filament:C"], "name": "Syncoilin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027705": {"description": "Flotillin family", "go_ids": [], "go_terms": [], "name": "Flotillin_fam", "pathway_ids": ["R-RNO-9013026", "R-SSC-8849932", "R-BTA-9696273", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-BTA-5213460", "R-HSA-9013106", "R-SSC-9013026", "R-HSA-8849932", "R-SSC-8980692", "R-MMU-5213460", "R-BTA-5675482", "R-RNO-5213460", "R-RNO-9013106", "R-DME-8980692", "R-MMU-8849932", "R-HSA-5675482", "R-SSC-5675482", "R-MMU-5675482", "R-BTA-8849932", "R-RNO-9696273", "R-HSA-9696264", "R-HSA-5213460", "R-DME-8849932", "R-HSA-8980692", "R-MMU-9013026", "R-BTA-9696264", "R-RNO-9696264", "R-HSA-9013026", "R-BTA-8980692", "R-RNO-5675482", "R-SSC-5213460", "R-MMU-9696264", "R-SSC-9013106", "R-MMU-9696273", "R-RNO-8849932", "R-BTA-9013106", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-SSC-8849932:r:Synaptic adhesion-like molecules", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-BTA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SSC-9013026:r:RHOB GTPase cycle", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-SSC-8980692:r:RHOA GTPase cycle", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-8849932:r:Synaptic 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"type": "Family"}, "IPR027706": {"description": "PGP phosphatase, mitochondrial/chloroplastic", "go_ids": ["GO:0008962"], "go_terms": ["GO:0008962:phosphatidylglycerophosphatase activity:F"], "name": "PGP_Pase", "pathway_ids": ["PWY-5668", "PWY-7817", "PWY-5269"], "pathways": ["PWY-5668:t:cardiolipin biosynthesis I", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-5269:t:cardiolipin biosynthesis II"], "type": "Family"}, "IPR027707": {"description": "Troponin T", "go_ids": ["GO:0005861", "GO:0006937"], "go_terms": ["GO:0005861:troponin complex:C", "GO:0006937:regulation of muscle contraction:P"], "name": "TNNT", "pathway_ids": ["R-MMU-390522", "R-SSC-390522", "R-RNO-390522", "R-BTA-390522", "R-HSA-390522"], "pathways": ["R-MMU-390522:r:Striated Muscle Contraction", "R-SSC-390522:r:Striated Muscle Contraction", "R-RNO-390522:r:Striated Muscle Contraction", "R-BTA-390522:r:Striated Muscle Contraction", "R-HSA-390522:r:Striated Muscle Contraction"], "type": "Family"}, 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"PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565", "R-MMU-8955332", "R-RNO-8955332", "R-HSA-8955332"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "R-MMU-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-RNO-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Family"}, "IPR027756": {"description": "Ovo-like", "go_ids": [], "go_terms": [], "name": "Ovo-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027777": {"description": "Dynactin subunit 6", "go_ids": ["GO:0005869"], "go_terms": ["GO:0005869:dynactin complex:C"], "name": "DCTN6", "pathway_ids": ["R-BTA-6807878", "R-HSA-2132295", "R-SSC-2132295", "R-BTA-6811436", "R-SSC-3371497", "R-SSC-6807878", "R-DDI-6807878", "R-MMU-2132295", "R-HSA-6807878", "R-BTA-3371497", "R-CEL-6811436", "R-CEL-6807878", "R-HSA-3371497", "R-MMU-6807878", "R-BTA-2132295", "R-HSA-6811436", "R-MMU-3371497", "R-MMU-6811436"], "pathways": ["R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-2132295:r:MHC class II antigen presentation", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-BTA-2132295:r:MHC class II antigen presentation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR027783": {"description": "Bacterial Pleckstrin homology domain-related", "go_ids": [], "go_terms": [], "name": "Bacterial_PH-related", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027785": {"description": "UvrD-like helicase C-terminal domain", "go_ids": [], "go_terms": [], "name": "UvrD-like_helicase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027786": {"description": "Nse4/EID family", "go_ids": ["GO:0006281", "GO:0005634", "GO:0030915"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0005634:nucleus:C", "GO:0030915:Smc5-Smc6 complex:C"], "name": "Nse4/EID", "pathway_ids": ["R-SCE-3108214", "R-MMU-3108214", "R-SPO-3108214", "R-BTA-3108214", "R-RNO-3108214", "R-HSA-3108214"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Family"}, "IPR027787": {"description": "Alpha/beta-hydrolase, catalytic domain", "go_ids": [], "go_terms": [], "name": "Alpha/beta-hydrolase_catalytic", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027788": {"description": "Alpha/beta-hydrolase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Alpha/beta-hydrolase_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027789": {"description": "Syndecan/Neurexin domain", "go_ids": [], "go_terms": [], "name": "Syndecan/Neurexin_dom", "pathway_ids": ["R-SSC-3000170", "R-CEL-2022928", "R-MMU-2024096", "R-HSA-3560783", "R-BTA-3928662", "R-HSA-9918485", "R-HSA-3656237", "R-MMU-8957275", "R-MMU-3000170", "R-HSA-3928662", "R-RNO-2024096", "R-MMU-975634", "R-BTA-8957275", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-SSC-2022928", "R-CEL-3928662", "R-CEL-3000170", "R-HSA-381426", "R-MMU-449836", "R-BTA-1971475", "R-HSA-3000171", "R-HSA-1971475", "R-DME-3928662", "R-HSA-9694614", "R-BTA-975634", "R-HSA-9820960", "R-HSA-3560801", "R-RNO-381426", "R-HSA-4420332", "R-RNO-6794361", "R-BTA-3000170", "R-HSA-449836", "R-DME-381426", "R-DME-8957275", "R-DME-1971475", "R-CEL-2024096", "R-HSA-6794361", "R-BTA-2024096", "R-HSA-3656253", "R-RNO-8957275", "R-SSC-1971475", "R-BTA-381426", "R-HSA-2024096", "R-RNO-3928662", "R-MMU-2022928", "R-RNO-3000170", "R-HSA-2022928", "R-HSA-9833110", "R-RNO-975634", "R-BTA-449836", "R-HSA-9918481", "R-DME-2024096", "R-HSA-3000170", "R-SSC-2024096", "R-MMU-6794361", "R-DRE-6794361", "R-BTA-2022928", "R-SSC-975634", "R-RNO-1971475", "R-DME-2022928", "R-DME-3000170", "R-CEL-1971475", "R-RNO-2022928", "R-MMU-3928662", "R-HSA-8957275", "R-MMU-1971475", "R-RNO-449836", "R-HSA-202733", "R-HSA-975634"], "pathways": ["R-SSC-3000170:r:Syndecan interactions", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-2024096:r:HS-GAG degradation", "R-MMU-975634:r:Retinoid metabolism and transport", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-2022928:r:HS-GAG biosynthesis", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-CEL-3000170:r:Syndecan interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-449836:r:Other interleukin signaling", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-9694614:r:Attachment and Entry", "R-BTA-975634:r:Retinoid metabolism and transport", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-6794361:r:Neurexins and neuroligins", "R-BTA-3000170:r:Syndecan interactions", "R-HSA-449836:r:Other interleukin signaling", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-2024096:r:HS-GAG degradation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-BTA-2024096:r:HS-GAG degradation", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2024096:r:HS-GAG degradation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-RNO-3000170:r:Syndecan interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-9833110:r:RSV-host interactions", "R-RNO-975634:r:Retinoid metabolism and transport", "R-BTA-449836:r:Other interleukin signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-2024096:r:HS-GAG degradation", "R-HSA-3000170:r:Syndecan interactions", "R-SSC-2024096:r:HS-GAG degradation", "R-MMU-6794361:r:Neurexins and neuroligins", "R-DRE-6794361:r:Neurexins and neuroligins", "R-BTA-2022928:r:HS-GAG biosynthesis", "R-SSC-975634:r:Retinoid metabolism and transport", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-2022928:r:HS-GAG biosynthesis", "R-DME-3000170:r:Syndecan interactions", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Domain"}, "IPR027790": {"description": "S-adenosylmethionine synthase", "go_ids": [], "go_terms": [], "name": "AdoMet_synthase_2_family", "pathway_ids": ["PWY-5912", "PWY-6151", "PWY-5041"], "pathways": ["PWY-5912:t:2'-deoxymugineic acid phytosiderophore biosynthesis", "PWY-6151:t:S-adenosyl-L-methionine salvage I", "PWY-5041:t:S-adenosyl-L-methionine salvage II"], "type": "Family"}, "IPR027791": {"description": "Galactosyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "Galactosyl_T_C", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-6798695", "R-HSA-4793953", "R-DRE-913709", "R-CEL-975577", "R-DRE-975577", "R-DME-1971475", "R-MMU-913709", "R-HSA-3560783", "R-BTA-6798695", "R-CEL-9840309", "R-DRE-9840309", "R-HSA-5653890", "R-DME-975577", "R-BTA-2534343", "R-MMU-5653890", "R-DRE-2022854", "R-BTA-2022854", "R-DME-2022854", "R-RNO-913709", "R-SSC-913709", "R-HSA-1912420", "R-MMU-2534343", "R-SSC-2022854", "R-BTA-975577", "R-HSA-1971475", "R-SSC-975577", "R-MMU-975577", "R-MMU-2022854", "R-DME-9840309", "R-HSA-3656244", "R-RNO-975577", "R-HSA-9840309", "R-HSA-2022854", "R-HSA-2534343", "R-CEL-1971475", "R-RNO-9840309", "R-SSC-9840309", "R-CEL-913709", "R-MMU-9840309", "R-RNO-2022854", "R-HSA-975577", "R-BTA-5653890", "R-MMU-6798695", "R-DME-913709", "R-MMU-1971475", "R-HSA-913709"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-4793953:r:Defective B4GALT1 causes CDG-2d", "R-DRE-913709:r:O-linked glycosylation of mucins", "R-CEL-975577:r:N-Glycan antennae elongation", "R-DRE-975577:r:N-Glycan antennae elongation", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-9840309:r:Glycosphingolipid biosynthesis", "R-DRE-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-5653890:r:Lactose synthesis", "R-DME-975577:r:N-Glycan antennae elongation", "R-BTA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-MMU-5653890:r:Lactose synthesis", "R-DRE-2022854:r:Keratan sulfate biosynthesis", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-DME-2022854:r:Keratan sulfate biosynthesis", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-SSC-913709:r:O-linked glycosylation of mucins", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-BTA-975577:r:N-Glycan antennae elongation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-975577:r:N-Glycan antennae elongation", "R-MMU-975577:r:N-Glycan antennae elongation", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-DME-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-RNO-975577:r:N-Glycan antennae elongation", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-SSC-9840309:r:Glycosphingolipid biosynthesis", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-975577:r:N-Glycan antennae elongation", "R-BTA-5653890:r:Lactose synthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-913709:r:O-linked glycosylation of mucins", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Domain"}, "IPR027794": {"description": "tRNase Z endonuclease", "go_ids": ["GO:0008033"], "go_terms": ["GO:0008033:tRNA processing:P"], "name": "tRNase_Z_dom", "pathway_ids": ["R-HSA-6785470", "R-HSA-8868766", "R-HSA-6784531", "R-HSA-9708296"], "pathways": ["R-HSA-6785470:r:tRNA processing in the mitochondrion", "R-HSA-8868766:r:rRNA processing in the mitochondrion", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis"], "type": "Domain"}, "IPR027795": {"description": "CASTOR, ACT domain", "go_ids": [], "go_terms": [], "name": "CASTOR_ACT_dom", "pathway_ids": ["R-RNO-9639288", "R-MMU-9639288", "R-HSA-9639288", "R-XTR-9639288", "R-BTA-9639288"], "pathways": ["R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-BTA-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR027796": {"description": "OTT_1508-like deaminase", "go_ids": [], "go_terms": [], "name": "OTT_1508_deam-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027797": {"description": "Pre-toxin TG domain", "go_ids": [], "go_terms": [], "name": "PT-TG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027798": {"description": "Ubiquitin Mut7-C domain", "go_ids": [], "go_terms": [], "name": "Ub_Mut7C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027801": {"description": "Centromere protein P", "go_ids": ["GO:0034080", "GO:0000775"], "go_terms": ["GO:0034080:CENP-A containing chromatin assembly:P", "GO:0000775:chromosome, centromeric region:C"], "name": "CENP-P", "pathway_ids": ["R-HSA-606279", "R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-DRE-2500257", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-HSA-5663220", "R-DRE-5663220", "R-MMU-606279", "R-DRE-2467813", "R-DRE-141444", "R-HSA-9648025", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR027802": {"description": "Multi-ubiquitin domain", "go_ids": [], "go_terms": [], "name": "Multi-ubiquitin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027803": {"description": "Toxin/Nuclease, N-terminal", "go_ids": [], "go_terms": [], "name": "Toxin/Nuc_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027805": {"description": "Transposase, Helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "Transposase_HTH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027806": {"description": "Harbinger transposase-derived nuclease domain", "go_ids": [], "go_terms": [], "name": "HARBI1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027811": {"description": "CRISPR-associated protein Cas8a1/Csx13, Myxan subtype, C-terminal", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Csx13_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027812": {"description": "Protein of unknown function DUF4653", "go_ids": [], "go_terms": [], "name": "DUF4653", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027813": {"description": "Protein of unknown function DUF4642", "go_ids": [], "go_terms": [], "name": "DUF4642", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027814": {"description": "Protein of unknown function DUF4562", "go_ids": [], "go_terms": [], "name": "DUF4562", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027815": {"description": "CSC1/OSCA1-like, cytosolic domain", "go_ids": [], "go_terms": [], "name": "CSC1/OSCA1-like_cyt", "pathway_ids": ["R-SCE-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-SPO-6798695", "R-DME-6798695"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR027816": {"description": "Membrane-anchored junction protein", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "MAJIN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027817": {"description": "Costars domain", "go_ids": [], "go_terms": [], "name": "Costars_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027818": {"description": "Sperm acrosome-associated protein 9", "go_ids": [], "go_terms": [], "name": "SPACA9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027819": {"description": "Guanine nucleotide exchange factor C9orf72", "go_ids": ["GO:0005085"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "C9orf72", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027820": {"description": "Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase, N-terminal", "go_ids": [], "go_terms": [], "name": "PpnN_N", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7570", "PWY-2681", "PWY-5316", "PWY-6617", "PWY-7564", "PWY-8106", "PWY-7569"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7570:t:blasticidin S biosynthesis", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-6617:t:adenosine nucleotides degradation III", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7569:t:arginomycin biosynthesis"], "type": "Domain"}, "IPR027821": {"description": "Shieldin complex subunit 1", "go_ids": ["GO:2001032"], "go_terms": ["GO:2001032:regulation of double-strand break repair via nonhomologous end joining:P"], "name": "SHLD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027822": {"description": "Uncharacterized protein CXorf49", "go_ids": [], "go_terms": [], "name": "CXorf49", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027823": {"description": "Domain of unknown function DUF4468 with TBP-like fold", "go_ids": [], "go_terms": [], "name": "DUF4468", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027824": {"description": "Domain of unknown function DUF4469 with IG-like fold", "go_ids": [], "go_terms": [], "name": "DUF4469", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027825": {"description": "Protein of unknown function DUF4522", "go_ids": [], "go_terms": [], "name": "DUF4522", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027826": {"description": "Domain of unknown function DUF4431", "go_ids": [], "go_terms": [], "name": "DUF4431", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027827": {"description": "Testis expressed protein 56", "go_ids": [], "go_terms": [], "name": "Tex56", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027828": {"description": "Protein of unknown function DUF4465", "go_ids": [], "go_terms": [], "name": "DUF4465", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027829": {"description": "Protein of unknown function DUF4625", "go_ids": [], "go_terms": [], "name": "DUF4625", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027830": {"description": "C5orf34-like, N-terminal", "go_ids": [], "go_terms": [], "name": "C5orf34-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027831": {"description": "Domain of unknown function DUF4485", "go_ids": [], "go_terms": [], "name": "DUF4485", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027833": {"description": "MGT5A-like, N-terminal", "go_ids": [], "go_terms": [], "name": "MGT5A-like_N", "pathway_ids": ["R-HSA-975577", "R-MMU-975577", "R-RNO-975577", "R-HSA-9694548"], "pathways": ["R-HSA-975577:r:N-Glycan antennae elongation", "R-MMU-975577:r:N-Glycan antennae elongation", "R-RNO-975577:r:N-Glycan antennae elongation", "R-HSA-9694548:r:Maturation of spike protein"], "type": "Domain"}, "IPR027834": {"description": "Pre-T-cell antigen receptor", "go_ids": [], "go_terms": [], "name": "PTCRA", "pathway_ids": ["R-HSA-9013508"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription"], "type": "Family"}, "IPR027835": {"description": "Transmembrane protein 174", "go_ids": [], "go_terms": [], "name": "TMEM174", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027836": {"description": "Protein of unknown function DUF4529", "go_ids": [], "go_terms": [], "name": "DUF4529", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027837": {"description": "Kinocilin protein", "go_ids": [], "go_terms": [], "name": "Kinocilin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027838": {"description": "Domain of unknown function DUF4585", "go_ids": [], "go_terms": [], "name": "DUF4585", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027839": {"description": "Protein of unknown function DUF4432", "go_ids": [], "go_terms": [], "name": "DUF4432", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027840": {"description": "Domain of unknown function DUF4493", "go_ids": [], "go_terms": [], "name": "DUF4493", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027841": {"description": "Interleukin-17 receptor C/E, N-terminal", "go_ids": [], "go_terms": [], "name": "IL-17_rcpt_C/E_N", "pathway_ids": ["R-HSA-448424", "R-HSA-9705671"], "pathways": ["R-HSA-448424:r:Interleukin-17 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses"], "type": "Domain"}, "IPR027842": {"description": "HAM1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HAM1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027843": {"description": "Domain of unknown function DUF4440", "go_ids": [], "go_terms": [], "name": "DUF4440", "pathway_ids": [], "pathways": [], "type": "Domain"}, 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"Domain"}, "IPR027850": {"description": "Protein of unknown function DUF4504", "go_ids": [], "go_terms": [], "name": "DUF4504", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027851": {"description": "Protein of unknown function DUF4628", "go_ids": [], "go_terms": [], "name": "DUF4628", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027852": {"description": "Steroid receptor-associated and regulated protein", "go_ids": [], "go_terms": [], "name": "C1ORF64", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027853": {"description": "Protein of unknown function DUF4492", "go_ids": [], "go_terms": [], "name": "DUF4492", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027854": {"description": "Short transmembrane mitochondrial protein 1", "go_ids": [], "go_terms": [], "name": "STMP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027855": {"description": "Domain of unknown function DUF4479", "go_ids": [], "go_terms": [], "name": 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response to replication stress", "R-SCE-68867:r:Assembly of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DDI-68867:r:Assembly of the pre-replicative complex", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-BTA-69052:r:Switching of origins to a post-replicative state", "R-SPO-69052:r:Switching of origins to a post-replicative state", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-CEL-68949:r:Orc1 removal from chromatin", "R-XTR-68949:r:Orc1 removal from chromatin", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-DDI-69052:r:Switching of origins to a post-replicative state", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SPO-68949:r:Orc1 removal from chromatin", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR027926": {"description": "Uncharacterised protein YqbF, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YqbF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027928": {"description": "Vascular endothelial growth factor, heparin-binding domain", "go_ids": ["GO:0008201"], "go_terms": ["GO:0008201:heparin binding:F"], "name": "VEGF_C", "pathway_ids": ["R-DRE-114608", "R-RNO-4420097", "R-HSA-1234158", "R-HSA-194138", "R-DRE-194313", "R-DRE-5218921", "R-MMU-4420097", "R-HSA-9679191", "R-HSA-6785807", "R-RNO-195399", "R-RNO-114608", "R-HSA-194313", "R-HSA-4420097", "R-HSA-5218921", "R-MMU-195399", "R-HSA-114608", "R-BTA-114608", "R-RNO-5218921", "R-BTA-4420097", "R-MMU-194313", "R-BTA-5218921", "R-MMU-114608", "R-HSA-8866910", "R-DRE-4420097", "R-BTA-195399", "R-HSA-195399", "R-MMU-5218921", "R-DRE-195399", "R-BTA-194313", "R-RNO-194313"], "pathways": ["R-DRE-114608:r:Platelet degranulation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-194138:r:Signaling by VEGF", "R-DRE-194313:r:VEGF ligand-receptor interactions", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-RNO-114608:r:Platelet degranulation", "R-HSA-194313:r:VEGF ligand-receptor interactions", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-194313:r:VEGF ligand-receptor interactions", "R-BTA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-BTA-194313:r:VEGF ligand-receptor interactions", "R-RNO-194313:r:VEGF ligand-receptor interactions"], "type": "Domain"}, "IPR027929": {"description": "D-amino acid oxidase regulator", "go_ids": [], "go_terms": [], "name": "DAOA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027930": {"description": "Protein of unknown function DUF4609", "go_ids": [], "go_terms": [], "name": "DUF4609", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027931": {"description": "Domain of unknown function DUF4595 with porin-like fold", "go_ids": [], "go_terms": [], "name": "DUF4595", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027932": {"description": "Protein of unknown function DUF4606", "go_ids": [], "go_terms": [], "name": "DUF4606", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027934": {"description": "Cellulose synthase, RING-type zinc finger", "go_ids": [], "go_terms": [], "name": "CES_Znf_RING", "pathway_ids": ["PWY-1001"], "pathways": ["PWY-1001:t:cellulose biosynthesis"], "type": "Domain"}, "IPR027935": {"description": "Di19, C-terminal", "go_ids": [], "go_terms": [], "name": "Di19_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027936": {"description": "Ephrin, transmembrane domain", "go_ids": [], "go_terms": [], "name": "EPH_TM", "pathway_ids": ["R-MMU-9013420", "R-CEL-3928663", "R-RNO-3928665", "R-RNO-3928662", "R-HSA-2682334", "R-HSA-9696273", "R-HSA-9013408", "R-CEL-3928662", "R-MMU-3928664", "R-CEL-9013423", "R-DRE-2682334", "R-HSA-9013420", "R-HSA-3928664", "R-HSA-9696270", "R-RNO-2682334", "R-MMU-9013424", "R-MMU-2682334", "R-RNO-3928663", "R-MMU-3928663", "R-RNO-3928664", "R-CEL-3928665", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-3928663", "R-HSA-3928665", "R-CEL-2682334", "R-MMU-3928662", "R-CEL-9013420", "R-DRE-3928665", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-2892247", "R-MMU-9696273", "R-MMU-9013149", "R-DRE-3928663", "R-CEL-3928664", "R-MMU-3928665", "R-DRE-3928662", "R-MMU-9013408", "R-CEL-9013424", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-9824272", "R-HSA-373760", "R-HSA-3928662", "R-CEL-9013149", "R-DRE-3928664", "R-HSA-9013423"], "pathways": ["R-MMU-9013420:r:RHOU GTPase cycle", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928664:r:Ephrin signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-CEL-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9824272:r:Somitogenesis", "R-HSA-373760:r:L1CAM interactions", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DRE-3928664:r:Ephrin signaling", "R-HSA-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR027937": {"description": "Photoreceptor disk component PRCD", "go_ids": ["GO:0042622"], "go_terms": ["GO:0042622:photoreceptor outer segment membrane:C"], "name": "PRCD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027938": {"description": "Adipogenin", "go_ids": ["GO:0045444"], "go_terms": ["GO:0045444:fat cell differentiation:P"], "name": "Adipogenin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027939": {"description": "NMT1/THI5 family", "go_ids": ["GO:0009228"], "go_terms": ["GO:0009228:thiamine biosynthetic process:P"], "name": "NMT1/THI5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027940": {"description": "Kita-kyushu lung cancer antigen 1", "go_ids": [], "go_terms": [], "name": "KKLCAg1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027941": {"description": "Placenta-specific protein 9", "go_ids": [], "go_terms": [], "name": "PLAC9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027942": {"description": "Sieve element occlusion, N-terminal", "go_ids": [], "go_terms": [], "name": "SEO_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027943": {"description": "FAM209 family", "go_ids": [], "go_terms": [], "name": "FAM209", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027944": {"description": "Sieve element occlusion, C-terminal", "go_ids": [], "go_terms": [], "name": "SEO_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027945": {"description": "SseB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SseB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027946": {"description": "Oligogalacturonate lyase domain", "go_ids": ["GO:0047487", "GO:0045490"], "go_terms": ["GO:0047487:oligogalacturonide lyase activity:F", "GO:0045490:pectin catabolic process:P"], "name": "Ogl_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027947": {"description": "TMEM240 family", "go_ids": [], "go_terms": [], "name": "TMEM240", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027948": {"description": "Domain of unknown function DUF4436", "go_ids": [], "go_terms": [], "name": "DUF4436", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027949": {"description": "Petal formation-expressed", "go_ids": [], "go_terms": [], "name": "Chloroplast_duf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027950": {"description": "Protein of unknown function DUF4576", "go_ids": [], "go_terms": [], "name": "DUF4576", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027951": {"description": "Nucleolus and neural progenitor protein-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Nepro_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027952": {"description": "Domain of unknown function DUF4632", "go_ids": [], "go_terms": [], "name": "DUF4632", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027953": {"description": "Domain of unknown function DUF4605", "go_ids": [], "go_terms": [], "name": "DUF4605", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027954": {"description": "Transcobalamin-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Transcobalamin-like_C", "pathway_ids": ["R-HSA-9758890", "R-HSA-6798695", "R-RNO-9758890", "R-HSA-9758881"], "pathways": ["R-HSA-9758890:r:Transport of RCbl within the body", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9758890:r:Transport of RCbl within the body", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes"], "type": "Domain"}, "IPR027955": {"description": "Protein of unknown function DUF4636", "go_ids": [], "go_terms": [], "name": "DUF4636", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027956": {"description": "CIROZ", "go_ids": [], "go_terms": [], "name": "CIROZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027957": {"description": "Protein of unknown function DUF4634", "go_ids": [], "go_terms": [], "name": "DUF4634", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027958": {"description": "Domain of unknown function DUF4657", "go_ids": [], "go_terms": [], "name": "DUF4657", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027959": {"description": "Domain of unknown function DUF4627", "go_ids": [], "go_terms": [], "name": "DUF4627", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027960": {"description": "Protein of unknown function DUF4519", "go_ids": [], "go_terms": [], "name": "DUF4519", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027961": {"description": "Protein of unknown function DUF4442", "go_ids": [], "go_terms": [], "name": "DUF4442", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027962": {"description": "Glutamate-rich protein 3", "go_ids": [], "go_terms": [], "name": "ERICH3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027963": {"description": "Meiosis-specific coiled-coil domain-containing protein MEIOC", "go_ids": ["GO:0051321"], "go_terms": ["GO:0051321:meiotic cell cycle:P"], "name": "MEIOC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027965": {"description": "Sperm-associated microtubule inner protein 10", "go_ids": [], "go_terms": [], "name": "SPMIP10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027966": {"description": "FANCD2 opposite strand protein", "go_ids": [], "go_terms": [], "name": "FANCD2OS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027967": {"description": "Protein of unknown function DUF4612", "go_ids": [], "go_terms": [], "name": "DUF4612", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027968": {"description": "Jhy protein", "go_ids": [], "go_terms": [], "name": "JHY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027969": {"description": "Small membrane A-kinase anchor protein", "go_ids": ["GO:0034237"], "go_terms": ["GO:0034237:protein kinase A regulatory subunit binding:F"], "name": "Small_membr_AKAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027970": {"description": "SPATA31-like", "go_ids": [], "go_terms": [], "name": "SPATA31-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027971": {"description": "Elongin BC and Polycomb repressive complex 2-associated protein EPOP-like", "go_ids": [], "go_terms": [], "name": "EPOP", "pathway_ids": ["R-HSA-212300"], "pathways": ["R-HSA-212300:r:PRC2 methylates histones and DNA"], "type": "Family"}, "IPR027972": {"description": "Protein of unknown function DUF4489", "go_ids": [], "go_terms": [], "name": "DUF4489", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027973": {"description": "40S small subunit processome assembly factor 1-like", "go_ids": [], "go_terms": [], "name": "FSAF1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027974": {"description": "Domain of unknown function DUF4470", "go_ids": [], "go_terms": [], "name": "DUF4470", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027975": {"description": "TMEM71 protein family", "go_ids": [], "go_terms": [], "name": "TMEM71", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027976": {"description": "TATA box-binding protein-associated factor 1D", "go_ids": ["GO:0005668", "GO:0006355", "GO:0005634"], "go_terms": ["GO:0005668:RNA polymerase transcription factor SL1 complex:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0005634:nucleus:C"], "name": "TAF1D", "pathway_ids": ["R-BTA-73762", "R-HSA-73772", "R-MMU-5250924", "R-HSA-73863", "R-RNO-73772", "R-MMU-73762", "R-HSA-427359", "R-HSA-5250924", "R-MMU-73863", "R-HSA-427413", "R-MMU-73772", "R-BTA-5250924", "R-RNO-5250924", "R-RNO-73863", "R-BTA-73772", "R-HSA-73762", "R-RNO-73762", "R-BTA-73863"], "pathways": ["R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-BTA-73863:r:RNA Polymerase I Transcription Termination"], "type": "Family"}, "IPR027977": {"description": "Protein of unknown function DUF4621", "go_ids": [], "go_terms": [], "name": "DUF4621", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027978": {"description": "Protein of unknown function DUF4644", "go_ids": [], "go_terms": [], "name": "DUF4644", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027979": {"description": "Septin-4", "go_ids": [], "go_terms": [], "name": "Septin-4", "pathway_ids": ["R-HSA-111469", "R-HSA-111457"], "pathways": ["R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria"], "type": "Family"}, "IPR027980": {"description": "RamQ-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RamQ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027981": {"description": "Protein of unknown function DUF4446", "go_ids": [], "go_terms": [], "name": "DUF4446", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027984": {"description": "TMEM95 family", "go_ids": ["GO:0007342", "GO:0097524"], "go_terms": ["GO:0007342:fusion of sperm to egg plasma membrane involved in single fertilization:P", "GO:0097524:sperm plasma membrane:C"], "name": "TMEM95", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027985": {"description": "Rab15 effector", "go_ids": ["GO:0001881"], "go_terms": ["GO:0001881:receptor recycling:P"], "name": "Rab15_effector", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027986": {"description": "T-cell activation inhibitor, mitochondrial", "go_ids": [], "go_terms": [], "name": "TCAIM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027987": {"description": "Interleukin-31", "go_ids": [], "go_terms": [], "name": "IL-31", "pathway_ids": ["R-MMU-6788467", "R-HSA-6788467"], "pathways": ["R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Family"}, "IPR027988": {"description": "Transcription factor BREVIS RADIX, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BRX_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027989": {"description": "Domain of unknown function DUF4461", "go_ids": [], "go_terms": [], "name": "DUF4461", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027990": {"description": "Protein of unknown function DUF4633", "go_ids": [], "go_terms": [], "name": "DUF4633", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027991": {"description": "Domain of unknown function DUF4488", "go_ids": [], "go_terms": [], "name": "DUF4488", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027992": {"description": "Possible tRNA binding domain", "go_ids": [], "go_terms": [], "name": "tRNA_bind_dom", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-6790901"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR027993": {"description": "Protein of unknown function DUF4495", "go_ids": [], "go_terms": [], "name": "DUF4495", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027994": {"description": "WxL domain", "go_ids": [], "go_terms": [], "name": "WxL_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027995": {"description": "Galactosyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "Galactosyl_T_N", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-6798695", "R-HSA-4793953", "R-DRE-913709", "R-CEL-975577", "R-DRE-975577", "R-DME-1971475", "R-MMU-913709", "R-HSA-3560783", "R-BTA-6798695", "R-CEL-9840309", "R-DRE-9840309", "R-HSA-5653890", "R-DME-975577", "R-BTA-2534343", "R-MMU-5653890", "R-DRE-2022854", "R-BTA-2022854", "R-DME-2022854", "R-RNO-913709", "R-SSC-913709", "R-HSA-1912420", "R-MMU-2534343", "R-SSC-2022854", "R-BTA-975577", "R-HSA-1971475", "R-SSC-975577", "R-MMU-975577", "R-MMU-2022854", "R-DME-9840309", "R-HSA-3656244", "R-RNO-975577", "R-HSA-9840309", "R-HSA-2022854", "R-HSA-2534343", "R-CEL-1971475", "R-RNO-9840309", "R-SSC-9840309", "R-CEL-913709", "R-MMU-9840309", "R-RNO-2022854", "R-HSA-975577", "R-BTA-5653890", "R-MMU-6798695", "R-DME-913709", "R-MMU-1971475", "R-HSA-913709"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-4793953:r:Defective B4GALT1 causes CDG-2d", "R-DRE-913709:r:O-linked glycosylation of mucins", "R-CEL-975577:r:N-Glycan antennae elongation", "R-DRE-975577:r:N-Glycan antennae elongation", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-9840309:r:Glycosphingolipid biosynthesis", "R-DRE-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-5653890:r:Lactose synthesis", "R-DME-975577:r:N-Glycan antennae elongation", "R-BTA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-MMU-5653890:r:Lactose synthesis", "R-DRE-2022854:r:Keratan sulfate biosynthesis", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-DME-2022854:r:Keratan sulfate biosynthesis", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-SSC-913709:r:O-linked glycosylation of mucins", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-BTA-975577:r:N-Glycan antennae elongation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-975577:r:N-Glycan antennae elongation", "R-MMU-975577:r:N-Glycan antennae elongation", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-DME-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-RNO-975577:r:N-Glycan antennae elongation", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-SSC-9840309:r:Glycosphingolipid biosynthesis", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-975577:r:N-Glycan antennae elongation", "R-BTA-5653890:r:Lactose synthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-913709:r:O-linked glycosylation of mucins", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Domain"}, "IPR027996": {"description": "Tubulin epsilon and delta complex protein 1 domain", "go_ids": [], "go_terms": [], "name": "TEDC1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR027997": {"description": "Protein Largen/Inhibitory synaptic factor 1", "go_ids": [], "go_terms": [], "name": "Largen/INSYN1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR027998": {"description": "Respiration factor 1", "go_ids": ["GO:0005739", "GO:0005634", "GO:0045333"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0005634:nucleus:C", "GO:0045333:cellular respiration:P"], "name": "Rsf1_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028000": {"description": "Pma1 stabilization in the Golgi protein 1", "go_ids": [], "go_terms": [], "name": "Pma1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028001": {"description": "Stabilizer of axonemal microtubules 5", "go_ids": [], "go_terms": [], "name": "SAXO5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028002": {"description": "Myb/SANT-like DNA-binding domain 5", "go_ids": [], "go_terms": [], "name": "Myb_DNA-bind_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028003": {"description": "Keratinocyte differentiation factor 1", "go_ids": ["GO:0003334"], "go_terms": ["GO:0003334:keratinocyte development:P"], "name": "KDF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028004": {"description": "Protein of unknown function DUF4643", "go_ids": [], "go_terms": [], "name": "DUF4643", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028005": {"description": "N-acetyltransferase ESCO, zinc-finger", "go_ids": [], "go_terms": [], "name": "AcTrfase_ESCO_Znf_dom", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-2468052", "R-DRE-2468052", "R-SCE-2468052", "R-MMU-2468052", "R-SPO-110320", "R-SPO-5656169", "R-DME-2468052"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DRE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-DME-2468052:r:Establishment of Sister Chromatid Cohesion"], "type": "Domain"}, "IPR028006": {"description": "Centrosomal protein 15-like", "go_ids": [], "go_terms": [], "name": "CEP15-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028007": {"description": "Domain of unknown function DUF4459", "go_ids": [], "go_terms": [], "name": "DUF4459", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028008": {"description": "Protein of unknown function DUF4441", "go_ids": [], "go_terms": [], "name": "DUF4441", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028009": {"description": "N-acetyltransferase ESCO, acetyl-transferase domain", "go_ids": [], "go_terms": [], "name": "ESCO_Acetyltransf_dom", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-2468052", "R-DRE-2468052", "R-SCE-2468052", "R-MMU-2468052", "R-SPO-110320", "R-SPO-5656169", "R-DME-2468052"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DRE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-DME-2468052:r:Establishment of Sister Chromatid Cohesion"], "type": "Domain"}, "IPR028010": {"description": "Gamma-secretase-activating protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GSAP_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028011": {"description": "Domain of unknown function DUF4476", "go_ids": [], "go_terms": [], "name": "DUF4476", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028012": {"description": "Transcription regulator Rua1, C-terminal", "go_ids": [], "go_terms": [], "name": "Rua1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028013": {"description": "Protein of unknown function DUF4437", "go_ids": [], "go_terms": [], "name": "DUF4437", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028014": {"description": "Transmembrane protein 255", "go_ids": [], "go_terms": [], "name": "TMEM255", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028015": {"description": "CCDC84-like", "go_ids": [], "go_terms": [], "name": "CCDC84-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028018": {"description": "Protein of unknown function DUF4646", "go_ids": [], "go_terms": [], "name": "DUF4646", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028019": {"description": "Protein of unknown function DUF4508", "go_ids": [], "go_terms": [], "name": "DUF4508", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028020": {"description": "ASX, DEUBAD domain", "go_ids": [], "go_terms": [], "name": "ASX_DEUBAD_dom", "pathway_ids": ["R-HSA-5689603", "R-MMU-5689603", "R-DME-5689603"], "pathways": ["R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases"], "type": "Domain"}, "IPR028021": {"description": "Katanin p80 subunit, C-terminal", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "Katanin_C-terminal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028022": {"description": "Protein of unknown function DUF4600", "go_ids": [], "go_terms": [], "name": "DUF4600", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028024": {"description": "Lysosomal enzyme trafficking factor", "go_ids": [], "go_terms": [], "name": "LYSET", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028025": {"description": "FAM229 protein", "go_ids": [], "go_terms": [], "name": "FAM229", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028026": {"description": "Domain of unknown function DUF4502", "go_ids": [], "go_terms": [], "name": "DUF4502", "pathway_ids": ["R-HSA-5693568", "R-MMU-5693568"], "pathways": ["R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates"], "type": "Domain"}, "IPR028027": {"description": "Sperm microtubule associated protein 1", "go_ids": [], "go_terms": [], "name": "SPMAP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028028": {"description": "Domain of unknown function DUF4450", "go_ids": [], "go_terms": [], "name": "DUF4450", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028029": {"description": "Signal transducer CD24", "go_ids": ["GO:0007155"], "go_terms": ["GO:0007155:cell adhesion:P"], "name": "CD24", "pathway_ids": ["R-HSA-9927418", "R-HSA-373760", "R-HSA-9927426"], "pathways": ["R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Family"}, "IPR028030": {"description": "Domain of unknown function DUF4592", "go_ids": [], "go_terms": [], "name": "DUF4592", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028031": {"description": "Domain of unknown function DUF4460", "go_ids": [], "go_terms": [], "name": "DUF4460", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028032": {"description": "Domain of unknown function DUF4503", "go_ids": [], "go_terms": [], "name": "DUF4503", "pathway_ids": ["R-HSA-5693568", "R-MMU-5693568"], "pathways": ["R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates"], "type": "Domain"}, "IPR028033": {"description": "Domain of unknown function DUF4462", "go_ids": [], "go_terms": [], "name": "DUF4462", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR028034": {"description": "CCDC81, HU domain 1", "go_ids": [], "go_terms": [], "name": "HU-CCDC81", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028036": {"description": "Distal membrane-arm assembly complex protein 1-like domain", "go_ids": [], "go_terms": [], "name": "DMAC1-like_dom", "pathway_ids": ["R-MMU-6799198", "R-HSA-6799198"], "pathways": ["R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis"], "type": "Domain"}, "IPR028037": {"description": "Antitoxin Rv0909/MT0933", "go_ids": [], "go_terms": [], "name": "Antitoxin_Rv0909/MT0933", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028038": {"description": "TM140 protein family", "go_ids": [], "go_terms": [], "name": "TM140", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028039": {"description": "Coiled-coil domain containing protein 32", "go_ids": [], "go_terms": [], "name": "CCDC32", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028040": {"description": "Type 2 DNA topoisomerase 6 subunit B-like", "go_ids": ["GO:0042138"], "go_terms": ["GO:0042138:meiotic DNA double-strand break formation:P"], "name": "TopoVIB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028041": {"description": "WD repeat and coiled-coil-containing protein family", "go_ids": [], "go_terms": [], "name": "WDCP", "pathway_ids": ["R-HSA-9725370"], "pathways": ["R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Family"}, "IPR028042": {"description": "Protein of unknown function DUF4639", "go_ids": [], "go_terms": [], "name": "DUF4639", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028043": {"description": "ATPase PAAT-like", "go_ids": [], "go_terms": [], "name": "PAAT-like", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR028044": {"description": "Domain of unknown function DUF4444", "go_ids": [], "go_terms": [], "name": "DUF4444", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028045": {"description": "Homologous recombination OB-fold protein", "go_ids": ["GO:0000725"], "go_terms": ["GO:0000725:recombinational repair:P"], "name": "HROB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028047": {"description": "Latrotoxin, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Latrotoxin_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028048": {"description": "HNH/Endo VII superfamily nuclease toxins", "go_ids": [], "go_terms": [], "name": "Tox-HNH-EHHH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028049": {"description": "NTF2 fold immunity protein", "go_ids": [], "go_terms": [], "name": "Imm-NTF2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028050": {"description": "Toxin in Odyssella and Amoebophilus", "go_ids": [], "go_terms": [], "name": "Tox-ODYAM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028051": {"description": "Chemotaxis phosphatase CheX-like domain", "go_ids": [], "go_terms": [], "name": "CheX-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028052": {"description": "Kinetochore assembly subunit CENP-C, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CENP-C_N_dom", "pathway_ids": ["R-MMU-2500257", "R-HSA-606279", "R-HSA-2500257", "R-MMU-141444", "R-HSA-2467813", "R-HSA-68877", "R-MMU-2467813", "R-MMU-606279", "R-HSA-141444", "R-HSA-5663220", "R-MMU-68877", "R-MMU-9648025", "R-HSA-9648025", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR028053": {"description": "Membrane insertase YidC, N-terminal", "go_ids": [], "go_terms": [], "name": "Membr_insert_YidC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028054": {"description": "Protein of unknown function DUF4481", "go_ids": [], "go_terms": [], "name": "DUF4481", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028055": {"description": "Membrane insertase YidC/Oxa/ALB, C-terminal", "go_ids": [], "go_terms": [], "name": "YidC/Oxa/ALB_C", "pathway_ids": ["R-BTA-5389840", "R-HSA-9864848", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-HSA-6799198", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-MMU-9864848", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9864848:r:Complex IV assembly", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Domain"}, "IPR028056": {"description": "Colicin M", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense response to bacterium:P"], "name": "Colicin_M", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028057": {"description": "DrrA phosphatidylinositol 4-phosphate binding domain", "go_ids": ["GO:0044161", "GO:0031267", "GO:0043087"], "go_terms": ["GO:0044161:host cell cytoplasmic vesicle:C", "GO:0031267:small GTPase binding:F", "GO:0043087:regulation of GTPase activity:P"], "name": "DrrA_P4M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028058": {"description": "Fis1, N-terminal tetratricopeptide repeat", "go_ids": [], "go_terms": [], "name": "Fis1_TPR_N", "pathway_ids": ["R-CEL-9603798", "R-SCE-9603798", "R-MMU-9603798", "R-DME-9603798", "R-HSA-9603798", "R-BTA-9603798", "R-SPO-9603798", "R-RNO-9603798"], "pathways": ["R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-DME-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import"], "type": "Repeat"}, "IPR028059": {"description": "Putative flagellar system-associated repeat", "go_ids": [], "go_terms": [], "name": "SWM_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR028060": {"description": "Big defensin domain", "go_ids": ["GO:0050829", "GO:0050830"], "go_terms": ["GO:0050829:defense response to Gram-negative bacterium:P", "GO:0050830:defense response to Gram-positive bacterium:P"], "name": "Defensin_big_dom", "pathway_ids": ["R-MMU-1461957", "R-BTA-1461973", "R-MMU-1461973", "R-CFA-1461973", "R-HSA-1461957", "R-HSA-1461973", "R-BTA-1461957"], "pathways": ["R-MMU-1461957:r:Beta defensins", "R-BTA-1461973:r:Defensins", "R-MMU-1461973:r:Defensins", "R-CFA-1461973:r:Defensins", "R-HSA-1461957:r:Beta defensins", "R-HSA-1461973:r:Defensins", "R-BTA-1461957:r:Beta defensins"], "type": "Domain"}, "IPR028061": {"description": "Fis1, C-terminal tetratricopeptide repeat", "go_ids": [], "go_terms": [], "name": "Fis1_TPR_C", "pathway_ids": ["R-CEL-9603798", "R-SCE-9603798", "R-MMU-9603798", "R-DME-9603798", "R-HSA-9603798", "R-BTA-9603798", "R-SPO-9603798", "R-RNO-9603798"], "pathways": ["R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-DME-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import"], "type": "Repeat"}, "IPR028062": {"description": "Kidney androgen-regulated protein", "go_ids": [], "go_terms": [], "name": "KAR_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028063": {"description": "Scrapie-responsive protein 1", "go_ids": [], "go_terms": [], "name": "SCRG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028064": {"description": "Transmembrane protein 154", "go_ids": [], "go_terms": [], "name": "TMEM154", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028065": {"description": "Telomere repeats-binding bouquet formation protein 2", "go_ids": [], "go_terms": [], "name": "TERB2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028066": {"description": "Transmembrane protein 187", "go_ids": [], "go_terms": [], "name": "TMEM187", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028067": {"description": "Interleukin-32", "go_ids": ["GO:0006955"], "go_terms": ["GO:0006955:immune response:P"], "name": "IL-32", "pathway_ids": ["R-HSA-9013423", "R-HSA-449836"], "pathways": ["R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-449836:r:Other interleukin signaling"], "type": "Family"}, "IPR028068": {"description": "Phosphoinositide-interacting protein", "go_ids": [], "go_terms": [], "name": "PIRT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028069": {"description": "Transmembrane protein 89", "go_ids": [], "go_terms": [], "name": "TMEM89", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028070": {"description": "G6B family", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "G6B", "pathway_ids": ["R-RNO-114604", "R-MMU-114604", "R-HSA-114604"], "pathways": ["R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-114604:r:GPVI-mediated activation cascade"], "type": "Family"}, "IPR028071": {"description": "Macro-like domain", "go_ids": [], "go_terms": [], "name": "Macro-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028072": {"description": "Domain of unknown function DUF4466", "go_ids": [], "go_terms": [], "name": "DUF4466", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028073": {"description": "PTHB1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PHTB1_N_dom", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR028074": {"description": "PTHB1, GAE domain", "go_ids": [], "go_terms": [], "name": "PHTB1_GAE_dom", "pathway_ids": ["R-MMU-5620922", "R-HSA-5620922"], "pathways": ["R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR028075": {"description": "Domain of unknown function DUF4467", "go_ids": [], "go_terms": [], "name": "DUF4467", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028076": {"description": "Staphopain proregion", "go_ids": [], "go_terms": [], "name": "Staphopain_pro", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028077": {"description": "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "UAE_UbL_dom", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-DRE-3065676", "R-SPO-3065676", "R-DDI-3065678", "R-HSA-3065676", "R-MMU-3065676", "R-HSA-3065678", "R-DDI-3065676", "R-DRE-3065678", "R-CEL-3065678", "R-CEL-3065676", "R-MMU-3065678", "R-SPO-3065678"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-SPO-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-DDI-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-HSA-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-MMU-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-HSA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DDI-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-DRE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-CEL-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-CEL-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-MMU-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SPO-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "type": "Domain"}, "IPR028078": {"description": "AP2-coincident, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ACDC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028079": {"description": "Zc3h12a-like Ribonuclease NYN domain", "go_ids": [], "go_terms": [], "name": "RNase_Zc3h12a_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028080": {"description": "Domain of unknown function DUF4454", "go_ids": [], "go_terms": [], "name": "DUF4454", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028081": {"description": "Leucine-binding protein domain", "go_ids": [], "go_terms": [], "name": "Leu-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028082": {"description": "Periplasmic binding protein-like I", "go_ids": [], "go_terms": [], "name": "Peripla_BP_I", "pathway_ids": ["R-MMU-416476", "R-MMU-204005", "R-DME-399710", "R-MMU-977444", "R-RNO-451307", "R-DME-420499", "R-MMU-451308", "R-MMU-9609736", "R-MMU-5694530", "R-SSC-420499", "R-MMU-8935690", "R-CEL-438066", "R-HSA-442982", "R-MMU-399710", "R-HSA-5694530", "R-SSC-8935690", "R-HSA-3928662", "R-CEL-451307", "R-BTA-418594", "R-CFA-8849932", "R-MMU-9717207", "R-CEL-451308", "R-CEL-204005", "R-HSA-8942233", "R-HSA-1296041", "R-CFA-5673001", "R-BTA-5578768", "R-RNO-416476", "R-MMU-5673001", "R-DME-438066", "R-RNO-5673001", "R-MMU-5578768", "R-RNO-997272", "R-BTA-420499", "R-CEL-5694530", "R-HSA-451308", "R-HSA-2514859", "R-RNO-9717207", "R-MMU-8849932", "R-MMU-438066", "R-RNO-5578768", "R-HSA-420499", "R-RNO-420499", "R-MMU-420499", "R-DME-3928662", "R-RNO-399710", "R-RNO-438066", "R-MMU-1296041", "R-HSA-5673001", "R-BTA-416476", "R-HSA-204005", "R-CFA-3928662", "R-CEL-420499", "R-RNO-500657", "R-HSA-9620244", "R-CEL-399710", "R-MMU-997272", "R-RNO-6794361", "R-CEL-997272", "R-HSA-8935690", "R-HSA-9609736", "R-CEL-1296041", "R-RNO-8849932", "R-RNO-2514859", "R-CEL-8849932", "R-DME-9609736", "R-CFA-9609736", "R-DME-416993", "R-HSA-451307", "R-HSA-977444", "R-HSA-416476", "R-HSA-8849932", "R-HSA-399710", "R-MMU-418594", "R-CEL-500657", "R-HSA-6794361", "R-RNO-418594", "R-HSA-5578768", "R-HSA-500657", "R-MMU-2514859", "R-RNO-3928662", "R-DDI-418594", "R-RNO-451308", "R-DDI-977444", "R-HSA-997272", "R-HSA-9617324", "R-CEL-977444", "R-MMU-416993", "R-DRE-420499", "R-HSA-416993", "R-RNO-5694530", "R-HSA-399719", "R-MMU-500657", "R-RNO-977444", "R-MMU-6794361", "R-RNO-8935690", "R-DME-418594", "R-DDI-420499", "R-RNO-399719", "R-HSA-9032500", "R-CEL-418594", "R-SSC-416476", "R-RNO-204005", "R-RNO-9609736", "R-RNO-1296041", "R-DME-8849932", "R-HSA-418594", "R-HSA-9717207", "R-HSA-438066", "R-MMU-3928662", "R-SSC-418594", "R-HSA-9022699", "R-CFA-438066", "R-MMU-451307", "R-DRE-416476", "R-MMU-399719", "R-RNO-416993"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DME-399710:r:Activation of AMPA receptors", "R-MMU-977444:r:GABA B receptor activation", "R-RNO-451307:r:Activation of Na-permeable kainate receptors", "R-DME-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-5694530:r:Cargo concentration in the ER", "R-SSC-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-8935690:r:Digestion", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-MMU-399710:r:Activation of AMPA receptors", "R-HSA-5694530:r:Cargo concentration in the ER", "R-SSC-8935690:r:Digestion", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-451307:r:Activation of Na-permeable kainate receptors", "R-BTA-418594:r:G alpha (i) signalling events", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-HSA-8942233:r:Intestinal infectious diseases", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-BTA-5578768:r:Physiological factors", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5578768:r:Physiological factors", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-CEL-5694530:r:Cargo concentration in the ER", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-5578768:r:Physiological factors", "R-HSA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-RNO-399710:r:Activation of AMPA receptors", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-CFA-3928662:r:EPHB-mediated forward signaling", "R-CEL-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-500657:r:Presynaptic function of Kainate receptors", "R-HSA-9620244:r:Long-term potentiation", "R-CEL-399710:r:Activation of AMPA receptors", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-6794361:r:Neurexins and neuroligins", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-8935690:r:Digestion", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CEL-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DME-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-451307:r:Activation of Na-permeable kainate receptors", "R-HSA-977444:r:GABA B receptor activation", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-399710:r:Activation of AMPA receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-CEL-500657:r:Presynaptic function of Kainate receptors", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-5578768:r:Physiological factors", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DDI-418594:r:G alpha (i) signalling events", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-DDI-977444:r:GABA B receptor activation", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-CEL-977444:r:GABA B receptor activation", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DRE-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-RNO-977444:r:GABA B receptor activation", "R-MMU-6794361:r:Neurexins and neuroligins", "R-RNO-8935690:r:Digestion", "R-DME-418594:r:G alpha (i) signalling events", "R-DDI-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-CEL-418594:r:G alpha (i) signalling events", "R-SSC-416476:r:G alpha (q) signalling events", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-SSC-418594:r:G alpha (i) signalling events", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-451307:r:Activation of Na-permeable kainate receptors", "R-DRE-416476:r:G alpha (q) signalling events", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors"], "type": "Homologous_superfamily"}, "IPR028083": {"description": "Spt6 acidic, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Spt6_acidic_N_dom", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Domain"}, "IPR028084": {"description": "Folliculin-interacting protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FNIP_N_dom", "pathway_ids": ["R-MMU-9639288", "R-GGA-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-GGA-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR028085": {"description": "Folliculin-interacting protein, middle domain", "go_ids": [], "go_terms": [], "name": "FNIP_mid_dom", "pathway_ids": ["R-MMU-9639288", "R-GGA-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-GGA-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR028086": {"description": "Folliculin-interacting protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FNIP_C_dom", "pathway_ids": ["R-MMU-9639288", "R-GGA-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-GGA-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR028087": {"description": "Putative Flp pilus-assembly TadG-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Tad_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028088": {"description": "Helix-turn-helix DNA-binding domain of Spt6", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Spt6_HTH_DNA-bd_dom", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Domain"}, "IPR028089": {"description": "Domain of unknown function DUF4455", "go_ids": [], "go_terms": [], "name": "DUF4455", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028090": {"description": "JAB domain, prokaryotic", "go_ids": [], "go_terms": [], "name": "JAB_dom_prok", "pathway_ids": ["R-MTU-936654"], "pathways": ["R-MTU-936654:r:Cysteine synthesis from O-phosphoserine"], "type": "Domain"}, "IPR028091": {"description": "FAM91, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FAM91_N_dom", "pathway_ids": ["R-HSA-9013407", "R-DRE-9013407", "R-MMU-9013407"], "pathways": ["R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle"], "type": "Domain"}, "IPR028092": {"description": "Retinal degeneration protein 3", "go_ids": [], "go_terms": [], "name": "RD3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028094": {"description": "Restriction of telomere capping protein 4, C-terminal", "go_ids": [], "go_terms": [], "name": "RTC4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028095": {"description": "Mso1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Mso1_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028096": {"description": "EfeO-type cupredoxin-like domain", "go_ids": [], "go_terms": [], "name": "EfeO_Cupredoxin", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR028097": {"description": "FAM91, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FAM91_C_dom", "pathway_ids": ["R-HSA-9013407", "R-DRE-9013407", "R-MMU-9013407"], "pathways": ["R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle"], "type": "Domain"}, "IPR028098": {"description": "Glycosyltransferase subfamily 4-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Glyco_trans_4-like_N", "pathway_ids": ["R-SCE-446193", "R-MMU-446193", "R-HSA-4549349", "R-SPO-446193", "R-HSA-446193", "R-MTU-879299", "R-DDI-446193"], "pathways": ["R-SCE-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-4549349:r:Defective ALG2 causes CDG-1i", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-MTU-879299:r:Mycothiol biosynthesis", "R-DDI-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Domain"}, "IPR028099": {"description": "Protein of unknown function DUF4577", "go_ids": [], "go_terms": [], "name": "DUF4577", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028101": {"description": "Protein of unknown function DUF4616", "go_ids": [], "go_terms": [], "name": "DUF4616", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028102": {"description": "Protein of unknown function DUF4652", "go_ids": [], "go_terms": [], "name": "DUF4652", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028103": {"description": "Spatacsin", "go_ids": [], "go_terms": [], "name": "Spatacsin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028104": {"description": "Protein of unknown function DUF4553", "go_ids": [], "go_terms": [], "name": "DUF4553", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028105": {"description": "Protein of unknown function DUF4651", "go_ids": [], "go_terms": [], "name": "DUF4651", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028106": {"description": "Protein of unknown function DUF4578", "go_ids": [], "go_terms": [], "name": "DUF4578", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028107": {"description": "Spatacsin, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Spatacsin_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028108": {"description": "Protein of unknown function DUF4505", "go_ids": [], "go_terms": [], "name": "DUF4505", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028110": {"description": "Transmembrane protein 254", "go_ids": [], "go_terms": [], "name": "TMEM254", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028111": {"description": "Melanocortin-2 receptor accessory protein family", "go_ids": [], "go_terms": [], "name": "MRAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028112": {"description": "DNA polymerase III PolC-type, N-terminal domain I", "go_ids": [], "go_terms": [], "name": "DNA_PolC-type_N_I", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028113": {"description": "Protein of unknown function DUF4624", "go_ids": [], "go_terms": [], "name": "DUF4624", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028114": {"description": "Protein of unknown function DUF4658", "go_ids": [], "go_terms": [], "name": "DUF4658", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028115": {"description": "Domain of unknown function DUF4484", "go_ids": [], "go_terms": [], "name": "DUF4484", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028116": {"description": "Tautomerase, cis-CaaD-like", "go_ids": [], "go_terms": [], "name": "Cis-CaaD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028118": {"description": "Chibby family", "go_ids": [], "go_terms": [], "name": "Chibby_fam", "pathway_ids": ["R-HSA-3769402", "R-MMU-3769402", "R-RNO-3769402", "R-BTA-3769402"], "pathways": ["R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-BTA-3769402:r:Deactivation of the beta-catenin transactivating complex"], "type": "Family"}, "IPR028119": {"description": "Snapin/Pallidin/Snn1", "go_ids": [], "go_terms": [], "name": "Snapin/Pallidin/Snn1", "pathway_ids": ["R-BTA-432722", "R-CEL-432722", "R-DME-432722", "R-HSA-432722", "R-RNO-432722", "R-MMU-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR028120": {"description": "Apolipoprotein C-IV", "go_ids": [], "go_terms": [], "name": "APOC4", "pathway_ids": ["R-RNO-8866423", "R-MMU-8866423", "R-MMU-8964046", "R-HSA-9029569", "R-HSA-8866423", "R-RNO-8964046", "R-HSA-8964046"], "pathways": ["R-RNO-8866423:r:VLDL assembly", "R-MMU-8866423:r:VLDL assembly", "R-MMU-8964046:r:VLDL clearance", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-8866423:r:VLDL assembly", "R-RNO-8964046:r:VLDL clearance", "R-HSA-8964046:r:VLDL clearance"], "type": "Family"}, "IPR028121": {"description": "TMEM213 family", "go_ids": [], "go_terms": [], "name": "TMEM213", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028122": {"description": "FAM24 family", "go_ids": [], "go_terms": [], "name": "FAM24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028123": {"description": "TMEM210 family", "go_ids": [], "go_terms": [], "name": "TMEM210", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028124": {"description": "Small acidic protein-like domain", "go_ids": [], "go_terms": [], "name": "SMAP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028126": {"description": "Spexin", "go_ids": ["GO:0005184"], "go_terms": ["GO:0005184:neuropeptide hormone activity:F"], "name": "Spexin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028127": {"description": "Ripply family", "go_ids": [], "go_terms": [], "name": "Ripply_fam", "pathway_ids": ["R-HSA-9824272"], "pathways": ["R-HSA-9824272:r:Somitogenesis"], "type": "Family"}, "IPR028128": {"description": "Vasculin family", "go_ids": ["GO:0003677", "GO:0003723", "GO:0006351", "GO:0005634", "GO:0045893"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003723:RNA binding:F", "GO:0006351:DNA-templated transcription:P", "GO:0005634:nucleus:C", "GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "Vasculin_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028129": {"description": "Consortin, C-terminal domain", "go_ids": ["GO:0005802", "GO:0071253", "GO:0042998"], "go_terms": ["GO:0005802:trans-Golgi network:C", "GO:0071253:connexin binding:F", "GO:0042998:positive regulation of Golgi to plasma membrane protein transport:P"], "name": "Consortin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028130": {"description": "Dermcidin", "go_ids": ["GO:0031640", "GO:0005576", "GO:0008233"], "go_terms": ["GO:0031640:killing of cells of another organism:P", "GO:0005576:extracellular region:C", "GO:0008233:peptidase activity:F"], "name": "Dermcidin", "pathway_ids": ["R-HSA-6803157"], "pathways": ["R-HSA-6803157:r:Antimicrobial peptides"], "type": "Family"}, "IPR028131": {"description": "Tubulinyl-Tyr carboxypeptidase", "go_ids": ["GO:0045765", "GO:0005737"], "go_terms": ["GO:0045765:regulation of angiogenesis:P", "GO:0005737:cytoplasm:C"], "name": "VASH1", "pathway_ids": ["R-HSA-8955332"], "pathways": ["R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Family"}, "IPR028133": {"description": "Dynamitin", "go_ids": ["GO:0007017", "GO:0005869"], "go_terms": ["GO:0007017:microtubule-based process:P", "GO:0005869:dynactin complex:C"], "name": "Dynamitin", "pathway_ids": ["R-RNO-380270", "R-SSC-5620912", "R-SSC-380270", "R-HSA-2132295", "R-SSC-3371497", "R-DME-3371497", "R-HSA-380284", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-BTA-380259", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-BTA-6807878", "R-SSC-2132295", "R-RNO-2565942", "R-BTA-2565942", "R-BTA-5620912", "R-RNO-380284", "R-MMU-2132295", "R-BTA-380320", "R-SSC-2565942", "R-MMU-5620912", "R-HSA-5620912", "R-DME-6807878", "R-BTA-380284", "R-BTA-2132295", "R-HSA-6811436", "R-SSC-8854518", "R-RNO-2132295", "R-SSC-380259", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-MMU-380259", "R-CEL-6811436", "R-HSA-6807878", "R-CEL-6807878", "R-DRE-380320", "R-MMU-380270", "R-HSA-380270", "R-RNO-380259", "R-MMU-6811436", "R-SSC-380284", "R-RNO-6811436", "R-BTA-6811436", "R-SSC-6807878", "R-BTA-8854518", "R-BTA-380270", "R-DDI-6807878", "R-MMU-8854518", "R-SSC-380320", "R-BTA-3371497", "R-MMU-3371497", "R-HSA-380259"], "pathways": ["R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-SSC-2132295:r:MHC class II antigen presentation", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-2132295:r:MHC class II antigen presentation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-RNO-2132295:r:MHC class II antigen presentation", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Family"}, "IPR028135": {"description": "Ubiquitin-like domain, USP-type", "go_ids": [], "go_terms": [], "name": "Ub_USP-typ", "pathway_ids": ["R-HSA-2173788", "R-MMU-5357786", "R-HSA-390471", "R-BTA-5357956", "R-BTA-5689880", "R-BTA-5357786", "R-HSA-5689880", "R-RNO-5357905", "R-MMU-5357956", "R-HSA-5357786", "R-RNO-5689880", "R-MMU-5689880", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357905", "R-RNO-5357956", "R-HSA-5689603", "R-RNO-5357786", "R-XTR-5689880", "R-BTA-5357905"], "pathways": ["R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5689603:r:UCH proteinases", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-XTR-5689880:r:Ub-specific processing proteases", "R-BTA-5357905:r:Regulation of TNFR1 signaling"], "type": "Domain"}, "IPR028137": {"description": "Syncollin", "go_ids": ["GO:0030667", "GO:0006887"], "go_terms": ["GO:0030667:secretory granule membrane:C", "GO:0006887:exocytosis:P"], "name": "Syncollin", "pathway_ids": ["R-HSA-9925561"], "pathways": ["R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells"], "type": "Family"}, "IPR028138": {"description": "Neuropeptide S", "go_ids": ["GO:0005576", "GO:0007218"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0007218:neuropeptide signaling pathway:P"], "name": "Neuropeptide_S", "pathway_ids": ["R-MMU-416476", "R-RNO-375276", "R-HSA-375276", "R-HSA-418555", "R-HSA-416476", "R-MMU-375276", "R-RNO-416476", "R-MMU-418555"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Family"}, "IPR028139": {"description": "Humanin family", "go_ids": [], "go_terms": [], "name": "Humanin", "pathway_ids": ["R-HSA-416476", "R-HSA-418594", "R-HSA-444473"], "pathways": ["R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands"], "type": "Family"}, "IPR028140": {"description": "Protein TraM", "go_ids": ["GO:0009372"], "go_terms": ["GO:0009372:quorum sensing:P"], "name": "TraM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028143": {"description": "GET complex subunit Get2/sif1", "go_ids": [], "go_terms": [], "name": "Get2/sif1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028144": {"description": "Cysteine-rich transmembrane domain", "go_ids": [], "go_terms": [], "name": "CYSTM_dom", "pathway_ids": ["R-DRE-6798695", "R-HSA-6798695"], "pathways": ["R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR028145": {"description": "Synaptonemal complex central element protein 3", "go_ids": ["GO:0007130", "GO:0007131", "GO:0007283"], "go_terms": ["GO:0007130:synaptonemal complex assembly:P", "GO:0007131:reciprocal meiotic recombination:P", "GO:0007283:spermatogenesis:P"], "name": "Synaptonemal_3", "pathway_ids": ["R-HSA-1221632"], "pathways": ["R-HSA-1221632:r:Meiotic synapsis"], "type": "Family"}, "IPR028146": {"description": "Glucosidase II beta subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "PRKCSH_N", "pathway_ids": ["R-BTA-8957275", "R-HSA-532668", "R-HSA-9683686", "R-HSA-879415", "R-MMU-381426", "R-HSA-9694548", "R-MMU-9768727", "R-BTA-381426", "R-BTA-9768727", "R-HSA-8957275", "R-HSA-9768727", "R-HSA-901042", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9694548:r:Maturation of spike protein", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR028147": {"description": "NELL2-interacting cofactor for lumicrine signalling", "go_ids": [], "go_terms": [], "name": "NICOL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028148": {"description": "Immunity protein 74", "go_ids": [], "go_terms": [], "name": "Imm74", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028149": {"description": "Tantalus-like", "go_ids": [], "go_terms": [], "name": "Tantalus-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028150": {"description": "Lustrin, cysteine-rich repeated", "go_ids": [], "go_terms": [], "name": "Lustrin_cystein", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR028153": {"description": "Transmembrane protein C12orf23, UPF0444", "go_ids": [], "go_terms": [], "name": "UPF0444", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028154": {"description": "AMP-dependent ligase, C-terminal", "go_ids": [], "go_terms": [], "name": "AMP-dep_Lig_C", "pathway_ids": ["PWY-6318", "PWY-7716", "PWY-1341"], "pathways": ["PWY-6318:t:L-phenylalanine degradation IV (mammalian, via side chain)", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-1341:t:phenylacetate degradation II (anaerobic)"], "type": "Domain"}, "IPR028155": {"description": "RPA-interacting protein, central domain", "go_ids": [], "go_terms": [], "name": "RPA_interact_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028156": {"description": "RPA-interacting protein", "go_ids": [], "go_terms": [], "name": "RIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028157": {"description": "PELOTA RNA-binding domain", "go_ids": [], "go_terms": [], "name": "PELOTA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028158": {"description": "RPA-interacting protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RPA_interact_N_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028159": {"description": "RPA-interacting protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RPA_interact_C_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028160": {"description": "Ribosome biogenesis protein Slx9-like", "go_ids": ["GO:0000462", "GO:0030688", "GO:0030686", "GO:0005730"], "go_terms": ["GO:0000462:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA):P", "GO:0030688:preribosome, small subunit precursor:C", "GO:0030686:90S preribosome:C", "GO:0005730:nucleolus:C"], "name": "Slx9-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028161": {"description": "Siroheme biosynthesis protein Met8-like", "go_ids": ["GO:0043115", "GO:0004325", "GO:0019354"], "go_terms": ["GO:0043115:precorrin-2 dehydrogenase activity:F", "GO:0004325:protoporphyrin ferrochelatase activity:F", "GO:0019354:siroheme biosynthetic process:P"], "name": "Met8-like", "pathway_ids": ["PWY-5196", "PWY-5194", "PWY-7377"], "pathways": ["PWY-5196:t:factor 430 biosynthesis", "PWY-5194:t:siroheme biosynthesis", "PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Family"}, "IPR028162": {"description": "Siroheme biosynthesis protein Met8, C-terminal", "go_ids": [], "go_terms": [], "name": "Met8_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028163": {"description": "HAUS augmin-like complex subunit 6, N-terminal", "go_ids": [], "go_terms": [], "name": "HAUS_6_N", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-DRE-380320", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR028164": {"description": "TMEM61 protein family", "go_ids": [], "go_terms": [], "name": "TMEM61", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028165": {"description": "TMEM125 protein family", "go_ids": [], "go_terms": [], "name": "TMEM125", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028166": {"description": "Bifunctional transglycosylase second domain", "go_ids": [], "go_terms": [], "name": "UB2H", "pathway_ids": ["PWY-6471", "PWY-5265", "R-HSA-9638771"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)", "R-HSA-9638771:r:Action of antimicrobials"], "type": "Domain"}, "IPR028168": {"description": "KASH5-like coiled-coil domain", "go_ids": [], "go_terms": [], "name": "KASH5_CC", "pathway_ids": ["R-DRE-6798695"], "pathways": ["R-DRE-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR028169": {"description": "Raftlin family", "go_ids": [], "go_terms": [], "name": "Raftlin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028170": {"description": "Protein KASH5", "go_ids": ["GO:0034397", "GO:0034993"], "go_terms": ["GO:0034397:telomere localization:P", "GO:0034993:meiotic nuclear membrane microtubule tethering complex:C"], "name": "KASH5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028171": {"description": "Codanin-1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Codanin-1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028172": {"description": "Intraflagellar transport protein 20", "go_ids": [], "go_terms": [], "name": "FT20", "pathway_ids": ["R-HSA-5620924", "R-DRE-5620924", "R-BTA-5620924", "R-XTR-5620924", "R-MMU-5620924", "R-CEL-5620924"], "pathways": ["R-HSA-5620924:r:Intraflagellar transport", "R-DRE-5620924:r:Intraflagellar transport", "R-BTA-5620924:r:Intraflagellar transport", "R-XTR-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR028173": {"description": "Augurin", "go_ids": [], "go_terms": [], "name": "Augurin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028181": {"description": "SLP adapter and CSK-interacting membrane protein", "go_ids": ["GO:0001772", "GO:0016020", "GO:0097197"], "go_terms": ["GO:0001772:immunological synapse:C", "GO:0016020:membrane:C", "GO:0097197:tetraspanin-enriched microdomain:C"], "name": "SCIMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028182": {"description": "BMP-2-inducible protein kinase, C-terminal", "go_ids": [], "go_terms": [], "name": "BMP2K_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028183": {"description": "Ubiquinol-cytochrome-c reductase complex assembly factor 5", "go_ids": [], "go_terms": [], "name": "UQCC5", "pathway_ids": ["R-HSA-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly"], "type": "Family"}, "IPR028184": {"description": "Transcription cofactor vestigial-like protein 4", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "VGLL4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028185": {"description": "Immunity protein 70", "go_ids": [], "go_terms": [], "name": "Imm70", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028186": {"description": "Transmembrane protein 191B/C", "go_ids": [], "go_terms": [], "name": "TMEM191B/C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028187": {"description": "STAT6, C-terminal", "go_ids": [], "go_terms": [], "name": "STAT6_C", "pathway_ids": ["R-MMU-3249367", "R-HSA-6785807", "R-MMU-6785807", "R-MMU-186763", "R-HSA-3249367", "R-HSA-186763"], "pathways": ["R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-186763:r:Downstream signal transduction"], "type": "Domain"}, "IPR028188": {"description": "Type IV pilin PilA", "go_ids": [], "go_terms": [], "name": "Pilin_PilA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028189": {"description": "Nitrate reductase, alpha subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "Nitr_red_alph_N", "pathway_ids": ["PWY-6748"], "pathways": ["PWY-6748:t:nitrate reduction VII (denitrification)"], "type": "Domain"}, "IPR028190": {"description": "Novel toxin 21", "go_ids": [], "go_terms": [], "name": "Ntox21", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028191": {"description": "WASH complex subunit 4, N-terminal", "go_ids": [], "go_terms": [], "name": "WASH-4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028192": {"description": "Bcl-2-modifying factor", "go_ids": ["GO:0006915"], "go_terms": ["GO:0006915:apoptotic process:P"], "name": "BMF", "pathway_ids": ["R-MMU-111453", "R-MMU-139910", "R-HSA-111453", "R-HSA-139910", "R-RNO-139910"], "pathways": ["R-MMU-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-MMU-139910:r:Activation of BMF and translocation to mitochondria", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-HSA-139910:r:Activation of BMF and translocation to mitochondria", "R-RNO-139910:r:Activation of BMF and translocation to mitochondria"], "type": "Family"}, "IPR028193": {"description": "Testis-expressed protein 13 A-D, N-terminal", "go_ids": [], "go_terms": [], "name": "TEX13A-D_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028194": {"description": "Coiled-coil domain-containing protein 167", "go_ids": [], "go_terms": [], "name": "CC167", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028195": {"description": "Sperm microtubule inner protein 6", "go_ids": [], "go_terms": [], "name": "SPMIP6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028196": {"description": "Keratinocyte differentiation-associated protein", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "KRTDAP", "pathway_ids": ["R-HSA-9725554"], "pathways": ["R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin"], "type": "Family"}, "IPR028197": {"description": "Syntaphilin/Syntabulin", "go_ids": [], "go_terms": [], "name": "Syntaphilin/Syntabulin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028198": {"description": "Surfactant-associated protein 2", "go_ids": [], "go_terms": [], "name": "SFTA2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028199": {"description": "Mucin, catalytic, TM and cytoplasmic tail domain", "go_ids": [], "go_terms": [], "name": "Mucin_dom", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-913709", "R-HSA-977068", "R-HSA-5083625"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC"], "type": "Domain"}, "IPR028200": {"description": "Immunity protein 31", "go_ids": [], "go_terms": [], "name": "Imm31", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028202": {"description": "Reductase, C-terminal", "go_ids": [], "go_terms": [], "name": "Reductase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028203": {"description": "Photosynthesis system II assembly factor Ycf48/Hcf136-like domain", "go_ids": [], "go_terms": [], "name": "PSII_CF48-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028204": {"description": "Tricorn protease C1 domain", "go_ids": [], "go_terms": [], "name": "Tricorn_C1", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR028205": {"description": "Late cornified envelope protein", "go_ids": ["GO:0008544"], "go_terms": ["GO:0008544:epidermis development:P"], "name": "LCE", "pathway_ids": ["R-HSA-6809371"], "pathways": ["R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Family"}, "IPR028206": {"description": "Psoriasis susceptibility 1 candidate 1", "go_ids": [], "go_terms": [], "name": "SEEK1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028207": {"description": "DNA polymerase beta, palm domain", "go_ids": [], "go_terms": [], "name": "DNA_pol_B_palm_palm", "pathway_ids": ["R-BTA-5649702", "R-BTA-110373", "R-MMU-5649702", "R-MMU-5693571", "R-BTA-5689880", "R-DRE-110381", "R-HSA-5689880", "R-DRE-5649702", "R-SCE-110362", "R-RNO-110362", "R-DRE-110373", "R-MMU-110381", "R-HSA-5649702", "R-DRE-110362", "R-RNO-110381", "R-MMU-5689880", "R-MMU-110362", "R-BTA-5651801", "R-BTA-73930", "R-HSA-110373", "R-DRE-5689880", "R-MMU-5651801", "R-HSA-110362", "R-BTA-110381", "R-HSA-5651801", "R-BTA-110362", "R-RNO-5693571", "R-RNO-5689880", "R-RNO-5649702", "R-MMU-110373", "R-HSA-5693571", "R-RNO-73930", "R-HSA-110381", "R-MMU-73930", "R-RNO-5651801", "R-DRE-5651801", "R-DRE-73930", "R-HSA-73930", "R-RNO-110373"], "pathways": ["R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-BTA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DRE-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-SCE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "type": "Domain"}, "IPR028208": {"description": "Effector protein NleD-like", "go_ids": [], "go_terms": [], "name": "Effector_pro_NleD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028209": {"description": "LAMTOR1/MEH1", "go_ids": ["GO:0043410", "GO:0045121", "GO:0001919", "GO:0007040", "GO:0016197", "GO:0032008", "GO:0071986", "GO:0071230", "GO:0042632", "GO:0031902"], "go_terms": ["GO:0043410:positive regulation of MAPK cascade:P", "GO:0045121:membrane raft:C", "GO:0001919:regulation of receptor recycling:P", "GO:0007040:lysosome organization:P", "GO:0016197:endosomal transport:P", "GO:0032008:positive regulation of TOR signaling:P", "GO:0071986:Ragulator complex:C", "GO:0071230:cellular response to amino acid stimulus:P", "GO:0042632:cholesterol homeostasis:P", "GO:0031902:late endosome membrane:C"], "name": "LAMTOR1/MEH1", 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"R-HSA-165159", "R-HSA-1632852", "R-RNO-9639288", "R-MMU-9013406", "R-MMU-166208", "R-MMU-6798695", "R-HSA-9013406", "R-MMU-9013149", "R-XTR-380972", "R-BTA-9639288", "R-HSA-9013407"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-1632852:r:Macroautophagy", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-166208:r:mTORC1-mediated signalling", "R-RNO-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-XTR-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-XTR-166208:r:mTORC1-mediated signalling", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-9013407:r:RHOH GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-165159:r:MTOR signalling", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-BTA-166208:r:mTORC1-mediated signalling", "R-MMU-165159:r:MTOR signalling", "R-RNO-9013407:r:RHOH GTPase cycle", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-165159:r:MTOR signalling", "R-XTR-9013408:r:RHOG GTPase cycle", "R-XTR-6798695:r:Neutrophil degranulation", "R-BTA-1632852:r:Macroautophagy", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-XTR-165159:r:MTOR signalling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-165159:r:MTOR signalling", "R-HSA-1632852:r:Macroautophagy", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-166208:r:mTORC1-mediated signalling", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-XTR-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR028211": {"description": "Pre-mRNA-splicing factor Ntr2", "go_ids": ["GO:0071008", "GO:0000390"], "go_terms": ["GO:0071008:U2-type post-mRNA release spliceosomal complex:C", "GO:0000390:spliceosomal complex disassembly:P"], "name": "Ntr2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028212": {"description": "Hypothetical glycosyl hydrolase 6", "go_ids": [], "go_terms": [], "name": "GHL6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028213": {"description": "PTIP-associated protein 1", "go_ids": [], "go_terms": [], "name": "PA1", "pathway_ids": ["R-BTA-9772755", "R-RNO-9772755", "R-HSA-9772755", "R-HSA-9818564", "R-MMU-9818564", "R-MMU-9772755", "R-BTA-9818564", "R-HSA-9841922", "R-HSA-5617472", "R-RNO-9818564"], "pathways": ["R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-BTA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes"], "type": "Family"}, "IPR028214": {"description": "Testis-specific serine kinase substrate", "go_ids": [], "go_terms": [], "name": "TSKS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028215": {"description": "Refilin family", "go_ids": ["GO:0031005", "GO:0061572", "GO:0061181"], "go_terms": ["GO:0031005:filamin binding:F", "GO:0061572:actin filament bundle organization:P", "GO:0061181:regulation of chondrocyte development:P"], "name": "Refilin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028216": {"description": "DDB1- and CUL4-associated factor 16", "go_ids": [], "go_terms": [], "name": "DCAF16", "pathway_ids": ["R-HSA-8951664"], "pathways": ["R-HSA-8951664:r:Neddylation"], "type": "Family"}, "IPR028217": {"description": "Ribosome-assembly protein 3, C-terminal", "go_ids": [], "go_terms": [], "name": "Rsa3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028218": {"description": "JAB-like toxin 1", "go_ids": [], "go_terms": [], "name": "Toxin-JAB1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028219": {"description": "Spermatogenesis-associated protein 19, mitochondrial", "go_ids": [], "go_terms": [], "name": "SPATA19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028221": {"description": "Junctional cadherin 5-associated protein", "go_ids": ["GO:0005911"], "go_terms": ["GO:0005911:cell-cell junction:C"], "name": "JCAD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028222": {"description": "AP-5 complex subunit zeta-1", "go_ids": ["GO:0044599"], "go_terms": ["GO:0044599:AP-5 adaptor complex:C"], "name": "AP5Z1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028224": {"description": "Otospiralin", "go_ids": ["GO:0007605"], "go_terms": ["GO:0007605:sensory perception of sound:P"], "name": "Otospiralin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028226": {"description": "Protein LIN37", "go_ids": ["GO:0017053"], "go_terms": ["GO:0017053:transcription repressor complex:C"], "name": "LIN37", "pathway_ids": ["R-MMU-1538133", "R-HSA-69656", "R-HSA-1362277", "R-HSA-69205", "R-HSA-1362300", "R-HSA-156711", "R-HSA-1538133", "R-HSA-69202", "R-BTA-1538133"], "pathways": ["R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-1538133:r:G0 and Early G1", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-BTA-1538133:r:G0 and Early G1"], "type": "Family"}, "IPR028227": {"description": "Uncharacterised protein family UPF0449", "go_ids": [], "go_terms": [], "name": "UPF0449", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028228": {"description": "Immunity protein 53", "go_ids": [], "go_terms": [], "name": "Imm53", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028229": {"description": "Integrase repeat unit", "go_ids": [], "go_terms": [], "name": "Integrase_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR028230": {"description": "Trimeric autotransporter adhesin, tryptophan-ring motif", "go_ids": [], "go_terms": [], "name": "TAA-Trp-ring", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028231": {"description": "Transcription elongation factor Spt6, YqgF domain", "go_ids": [], "go_terms": [], "name": "Spt6_YqgF", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Domain"}, "IPR028233": {"description": "Cilia BBSome complex subunit 10", "go_ids": ["GO:0060271", "GO:0034464"], "go_terms": ["GO:0060271:cilium assembly:P", "GO:0034464:BBSome:C"], "name": "BBIP10", "pathway_ids": ["R-DRE-5620922", "R-HSA-5620922"], "pathways": ["R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Family"}, "IPR028235": {"description": "Dynein assembly factor 3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DNAAF3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028236": {"description": "Ciliogenesis and planar polarity effector 1", "go_ids": [], "go_terms": [], "name": "CPLANE1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028237": {"description": "Proline-rich protein 15", "go_ids": [], "go_terms": [], "name": "PRR15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028238": {"description": "Bacterial toxin 46", "go_ids": [], "go_terms": [], "name": "Ntox46", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028241": {"description": "RAVE subunit 2/Rogdi", "go_ids": [], "go_terms": [], "name": "RAVE2/Rogdi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028243": {"description": "Paramyxovirus structural protein P/V, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Paramyxo_P/V_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028244": {"description": "Putative type VI secretion system, Rhs element associated Vgr domain", "go_ids": [], "go_terms": [], "name": "T6SS_Rhs_Vgr_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028245": {"description": "Eisosome component PIL1/LSP1", "go_ids": [], "go_terms": [], "name": "PIL1/LSP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028246": {"description": "Cation channel sperm-associated auxiliary subunit gamma", "go_ids": ["GO:0097228", "GO:0036128"], "go_terms": ["GO:0097228:sperm principal piece:C", "GO:0036128:CatSper complex:C"], "name": "CATSPERG", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Family"}, "IPR028248": {"description": "Transmembrane protein 190", "go_ids": [], "go_terms": [], "name": "TMEM190", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028250": {"description": "Thiol:disulfide interchange protein DsbD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DsbDN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028255": {"description": "Centromere protein T", "go_ids": ["GO:0000776", "GO:0051382", "GO:0003677"], "go_terms": ["GO:0000776:kinetochore:C", "GO:0051382:kinetochore assembly:P", "GO:0003677:DNA binding:F"], "name": "CENP-T", "pathway_ids": ["R-MMU-2500257", "R-HSA-606279", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-RNO-606279", "R-MMU-606279", "R-HSA-141444", "R-MMU-68877", "R-HSA-9648025", "R-RNO-5663220", "R-HSA-68877", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR028257": {"description": "Centrosomal protein of 126kDa", "go_ids": ["GO:1905515", "GO:0031122", "GO:0007052", "GO:0097546", "GO:0005813"], "go_terms": ["GO:1905515:non-motile cilium assembly:P", "GO:0031122:cytoplasmic microtubule organization:P", "GO:0007052:mitotic spindle organization:P", "GO:0097546:ciliary base:C", "GO:0005813:centrosome:C"], "name": "CEP126", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028258": {"description": "Exocyst complex component Sec3, PIP2-binding N-terminal domain", "go_ids": [], "go_terms": [], "name": "Sec3-PIP2_bind", "pathway_ids": ["R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-HSA-9920588", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-CEL-5620916", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Domain"}, "IPR028259": {"description": "AP2-like integrase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AP2-like_int_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028260": {"description": "FAM177 family", "go_ids": [], "go_terms": [], "name": "FAM177", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028261": {"description": "Dihydroprymidine dehydrogenase domain II", "go_ids": [], "go_terms": [], "name": "DPD_II", "pathway_ids": ["R-DDI-73621", "R-RNO-73621", "R-HSA-73621", "R-DRE-73621", "R-MMU-73621", "R-CEL-73621"], "pathways": ["R-DDI-73621:r:Pyrimidine catabolism", "R-RNO-73621:r:Pyrimidine catabolism", "R-HSA-73621:r:Pyrimidine catabolism", "R-DRE-73621:r:Pyrimidine catabolism", "R-MMU-73621:r:Pyrimidine catabolism", "R-CEL-73621:r:Pyrimidine catabolism"], "type": "Domain"}, "IPR028262": {"description": "CST complex subunit CTC1, plant", "go_ids": ["GO:0000723"], "go_terms": ["GO:0000723:telomere maintenance:P"], "name": "CTC1_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028263": {"description": "Flagellar motor switch protein FliG, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FliG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028264": {"description": "Immunity protein 15", "go_ids": [], "go_terms": [], "name": "Imm15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028265": {"description": "TTDN1/Protein SICKLE", "go_ids": [], "go_terms": [], "name": "TTDN1/SICKLE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028266": {"description": "Tumor protein p53-inducible protein 11", "go_ids": [], "go_terms": [], "name": "TP53I11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028267": {"description": "Rapamycin-insensitive companion of mTOR, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Pianissimo_N", "pathway_ids": ["R-MMU-9856530", "R-DDI-1257604", "R-MMU-5218920", "R-HSA-5674400", "R-MMU-6804757", "R-SPO-389357", "R-SPO-1257604", "R-SPO-5218920", "R-MMU-1257604", "R-SCE-389357", "R-DDI-6804757", "R-SCE-9856530", "R-MMU-389357", "R-HSA-5218920", "R-DDI-9856530", "R-SCE-6804757", "R-HSA-6804757", "R-DDI-5218920", "R-DDI-389357", "R-SCE-1257604", "R-HSA-389357", "R-HSA-9920951", "R-HSA-9856530", "R-HSA-1257604", "R-SPO-6804757", "R-SPO-9856530", "R-SCE-5218920"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Domain"}, "IPR028268": {"description": "Pianissimo family", "go_ids": ["GO:0031932", "GO:0031929"], "go_terms": ["GO:0031932:TORC2 complex:C", "GO:0031929:TOR signaling:P"], "name": "Pianissimo_fam", "pathway_ids": ["R-MMU-9856530", "R-DDI-1257604", "R-MMU-5218920", "R-HSA-5674400", "R-MMU-6804757", "R-SPO-389357", "R-SPO-1257604", "R-SPO-5218920", "R-MMU-1257604", "R-SCE-389357", "R-DDI-6804757", "R-SCE-9856530", "R-MMU-389357", "R-HSA-5218920", "R-DDI-9856530", "R-SCE-6804757", "R-HSA-6804757", "R-DDI-5218920", "R-DDI-389357", "R-SCE-1257604", "R-HSA-389357", "R-HSA-9920951", "R-HSA-9856530", "R-HSA-1257604", "R-SPO-6804757", "R-SPO-9856530", "R-SCE-5218920"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Family"}, "IPR028269": {"description": "AP-4 complex subunit epsilon-1, C-terminal", "go_ids": [], "go_terms": [], "name": "AP4E1_C", "pathway_ids": ["R-HSA-432722", "R-MMU-432720", "R-HSA-432720", "R-MMU-432722"], "pathways": ["R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR028271": {"description": "RNA guanine-N7 methyltransferase activating subunit", "go_ids": ["GO:0003723", "GO:0031533", "GO:0106005"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0031533:mRNA capping enzyme complex:C", "GO:0106005:RNA 5'-cap (guanine-N7)-methylation:P"], "name": "RAMAC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028274": {"description": "TerY-C metal binding domain", "go_ids": [], "go_terms": [], "name": "TerY-C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028275": {"description": "Clustered mitochondria protein, N-terminal", "go_ids": [], "go_terms": [], "name": "CLU_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028276": {"description": "Immunity protein 68", "go_ids": [], "go_terms": [], "name": "Imm68", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028277": {"description": "Lsm, C-terminal", "go_ids": [], "go_terms": [], "name": "Lsm_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028278": {"description": "Modulator of retrovirus infection", "go_ids": ["GO:2001033"], "go_terms": ["GO:2001033:negative regulation of double-strand break repair via nonhomologous end joining:P"], "name": "MRI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028280": {"description": "Protein Njmu-R1", "go_ids": ["GO:0005802"], "go_terms": ["GO:0005802:trans-Golgi network:C"], "name": "Njmu-R1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028281": {"description": "Siroheme synthase, central domain", "go_ids": [], "go_terms": [], "name": "Sirohaem_synthase_central", "pathway_ids": ["PWY-5196", "PWY-5194", "PWY-7377"], "pathways": ["PWY-5196:t:factor 430 biosynthesis", "PWY-5194:t:siroheme biosynthesis", "PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Domain"}, "IPR028282": {"description": "WASH complex subunit 7, central domain", "go_ids": [], "go_terms": [], "name": "WASH-7_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028283": {"description": "WASH complex subunit 7, C-terminal", "go_ids": [], "go_terms": [], "name": "WASH-7_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028288": {"description": "SCAR/WAVE family", "go_ids": ["GO:0030036", "GO:0005856"], "go_terms": ["GO:0030036:actin cytoskeleton organization:P", "GO:0005856:cytoskeleton:C"], "name": "SCAR/WAVE_fam", "pathway_ids": ["R-BTA-2029482", "R-DDI-2029482", "R-HSA-5663213", "R-HSA-9664422", "R-DDI-5663213", "R-RNO-9013149", "R-HSA-2029482", "R-MMU-9013404", "R-MMU-4420097", "R-MMU-2029482", "R-DDI-9013149", "R-RNO-2029482", "R-BTA-9013423", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013423", "R-RNO-5663213", "R-HSA-9013149", "R-MMU-5663213", "R-BTA-5663213", "R-HSA-4420097", "R-HSA-9013404", "R-BTA-9013404", "R-DDI-9013423", "R-DDI-9013404", "R-MMU-9013149", "R-RNO-4420097"], "pathways": ["R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Family"}, "IPR028290": {"description": "WASH1", "go_ids": ["GO:0071203", "GO:0043014", "GO:0034314", "GO:0005769"], "go_terms": ["GO:0071203:WASH complex:C", "GO:0043014:alpha-tubulin binding:F", "GO:0034314:Arp2/3 complex-mediated actin nucleation:P", "GO:0005769:early endosome:C"], "name": "WASH1", "pathway_ids": ["R-HSA-5663213", "R-HSA-9013149", "R-DME-2029482", "R-MMU-5663213", "R-RNO-5663213", "R-HSA-9013148", "R-HSA-2029482", "R-CEL-5663213", "R-HSA-9664422", "R-RNO-2029482", "R-MMU-2029482", "R-CEL-2029482", "R-DME-5663213"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs"], "type": "Family"}, "IPR028300": {"description": "Holliday junction resolvase-related", "go_ids": [], "go_terms": [], "name": "Holliday_junct_resolvase-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028307": {"description": "Lin-54 family", "go_ids": [], "go_terms": [], "name": "Lin-54_fam", "pathway_ids": ["R-MMU-1538133", "R-HSA-69656", "R-HSA-1362277", "R-CEL-1538133", "R-HSA-69205", "R-HSA-1362300", "R-HSA-156711", "R-DRE-1538133", "R-HSA-1538133", "R-HSA-69202", "R-XTR-1538133", "R-RNO-1538133", "R-DME-1538133"], "pathways": ["R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-156711:r:Polo-like kinase mediated events", "R-DRE-1538133:r:G0 and Early G1", "R-HSA-1538133:r:G0 and Early G1", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-1538133:r:G0 and Early G1", "R-RNO-1538133:r:G0 and Early G1", "R-DME-1538133:r:G0 and Early G1"], "type": "Family"}, "IPR028309": {"description": "Retinoblastoma protein family", "go_ids": ["GO:0051726", "GO:0006357"], "go_terms": ["GO:0051726:regulation of cell cycle:P", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "RB_fam", "pathway_ids": ["R-HSA-174178", "R-DDI-1538133", "R-HSA-69205", "R-CEL-69202", "R-DME-69231", "R-HSA-2559585", "R-RNO-174178", "R-CEL-113501", "R-HSA-9682706", "R-RNO-2559584", "R-HSA-69231", "R-MMU-2559584", "R-HSA-9764790", "R-MMU-174178", "R-HSA-9661070", "R-HSA-9841922", "R-MMU-69200", "R-HSA-9617828", "R-DME-113501", "R-CEL-2299718", "R-MMU-69202", "R-MMU-1538133", "R-CEL-69656", "R-HSA-69200", "R-CEL-1538133", "R-HSA-69656", "R-CEL-2559584", "R-HSA-1538133", "R-HSA-2559584", "R-RNO-69656", "R-HSA-2299718", "R-CEL-69231", "R-RNO-69200", "R-HSA-2173796", "R-RNO-1538133", "R-CEL-69200", "R-HSA-9661069", "R-HSA-113501", "R-RNO-69202", "R-RNO-2299718", "R-HSA-9694686", "R-DME-69202", "R-HSA-9687136", "R-DDI-113501", "R-HSA-1362300", "R-DDI-69231", "R-CEL-2173796", "R-DDI-69656", "R-MMU-113501", "R-DDI-69200", "R-MMU-2173796", "R-MMU-69231", "R-DME-1538133", "R-RNO-69231", "R-MMU-69656", "R-HSA-9725371", "R-RNO-113501", "R-DME-69200", "R-HSA-1362277", "R-MMU-2299718", "R-DDI-2299718", "R-DME-174178", "R-HSA-6804114", "R-DME-9841922", "R-RNO-9841922", "R-DME-2173796", "R-DDI-69202", "R-DDI-174178", "R-HSA-69202", "R-HSA-8940973", "R-DME-69656", "R-RNO-2173796"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-1538133:r:G0 and Early G1", "R-HSA-69205:r:G1/S-Specific Transcription", "R-CEL-69202:r:Cyclin E associated events during G1/S transition", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9661070:r:Defective translocation of RB1 mutants to the nucleus", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-1538133:r:G0 and Early G1", "R-CEL-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-1538133:r:G0 and Early G1", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-CEL-69231:r:Cyclin D associated events in G1", "R-RNO-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-1538133:r:G0 and Early G1", "R-CEL-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-DME-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", 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associated events during G1/S transition", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "type": "Family"}, "IPR028320": {"description": "RelA-associated inhibitor", "go_ids": ["GO:0008134", "GO:0006355"], "go_terms": ["GO:0008134:transcription factor binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "iASPP", "pathway_ids": ["R-HSA-6804759", "R-MMU-6804759"], "pathways": ["R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors"], "type": "Family"}, "IPR028322": {"description": "Proline-rich nuclear receptor coactivator-like, proline rich region", "go_ids": [], "go_terms": [], "name": "PNRC-like_rgn", "pathway_ids": ["R-RNO-975957", "R-XTR-975957", "R-HSA-975957", "R-DRE-975957", "R-BTA-975957", 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"R-BTA-1296072", "R-RNO-5576894", "R-CEL-5576890", "R-BTA-5576894", "R-DME-5576894", "R-GGA-381676", "R-RNO-381676", "R-RNO-1296072", "R-DME-5576890", "R-CEL-381676", "R-MMU-381676", "R-GGA-1296072", "R-HSA-381676", "R-HSA-1296072", "R-HSA-5576894", "R-DME-381676", "R-MMU-1296072", "R-RNO-5576890"], "pathways": ["R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-DME-1296072:r:Voltage gated Potassium channels", "R-MMU-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-RNO-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-CEL-5576890:r:Phase 3 - rapid repolarisation", "R-BTA-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-DME-5576894:r:Phase 1 - inactivation of fast Na+ channels", "R-GGA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-1296072:r:Voltage 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"R-CEL-173599", "R-RNO-173599", "R-MMU-173599", "R-DME-173599"], "pathways": ["PWY-7346:t:UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "R-BTA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-CEL-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-RNO-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DME-173599:r:Formation of the active cofactor, UDP-glucuronate"], "type": "Family"}, "IPR028357": {"description": "UDP-glucose 6-dehydrogenase, bacterial type", "go_ids": ["GO:0000271", "GO:0003979"], "go_terms": ["GO:0000271:polysaccharide biosynthetic process:P", "GO:0003979:UDP-glucose 6-dehydrogenase activity:F"], "name": "UDPglc_DH_bac", "pathway_ids": ["PWY-7346", "PWY-7820"], "pathways": ["PWY-7346:t:UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)"], "type": "Family"}, "IPR028358": {"description": "GDP-mannose 6-dehydrogenase", "go_ids": ["GO:0047919", "GO:0042121"], "go_terms": ["GO:0047919:GDP-mannose 6-dehydrogenase activity:F", "GO:0042121:alginic acid biosynthetic process:P"], "name": "GDPman_DH", "pathway_ids": ["PWY-6073", "PWY-6082"], "pathways": ["PWY-6073:t:alginate biosynthesis I (algal)", "PWY-6082:t:alginate biosynthesis II (bacterial)"], "type": "Family"}, "IPR028359": {"description": "UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase", "go_ids": ["GO:0016628", "GO:0000271"], "go_terms": ["GO:0016628:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor:F", "GO:0000271:polysaccharide biosynthetic process:P"], "name": "UDP_ManNAc/GlcNAc_DH", "pathway_ids": ["PWY-7335"], "pathways": ["PWY-7335:t:UDP-N-acetyl-alpha-D-mannosaminouronate biosynthesis"], "type": "Family"}, "IPR028361": {"description": "GPI-anchor transamidase", "go_ids": ["GO:0016255", "GO:0003923", "GO:0042765"], "go_terms": ["GO:0016255:attachment of GPI anchor to protein:P", "GO:0003923:GPI-anchor transamidase activity:F", "GO:0042765:GPI-anchor transamidase complex:C"], "name": "GPI_transamidase", "pathway_ids": ["R-MMU-162791", "R-HSA-162791", "R-BTA-162791"], "pathways": ["R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-HSA-162791:r:Attachment of GPI anchor to uPAR", "R-BTA-162791:r:Attachment of GPI anchor to uPAR"], "type": "Family"}, "IPR028362": {"description": "Alginate O-acetyltransferase AlgI", "go_ids": ["GO:0042121"], "go_terms": ["GO:0042121:alginic acid biosynthetic process:P"], "name": "AlgI", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR028363": {"description": "DNA-directed RNA polymerase, subunit RPB6", "go_ids": ["GO:0005665", "GO:0005634", "GO:0006351", "GO:0003899"], "go_terms": ["GO:0005665:RNA polymerase II, core complex:C", "GO:0005634:nucleus:C", "GO:0006351:DNA-templated transcription:P", "GO:0003899:DNA-directed RNA polymerase activity:F"], "name": "RPB6", "pathway_ids": ["R-RNO-6781823", "R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-CEL-72165", "R-DME-76061", "R-MMU-9770562", "R-RNO-73779", "R-HSA-73980", "R-HSA-427413", "R-CEL-72203", "R-DDI-73776", "R-DME-72163", "R-RNO-72163", "R-DDI-6782210", "R-SPO-6781823", "R-DME-75955", "R-DDI-72163", "R-RNO-9018519", "R-HSA-167158", "R-MMU-75955", "R-RNO-73776", "R-MMU-112382", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DME-72203", "R-DME-72086", "R-DDI-674695", "R-CEL-9770562", "R-HSA-76061", "R-MMU-76061", "R-CEL-75953", "R-SPO-6796648", "R-DME-75953", "R-HSA-749476", "R-CEL-73776", "R-DME-6782135", "R-SCE-76061", "R-DME-73762", "R-SPO-9018519", "R-SPO-76066", "R-MMU-72163", "R-HSA-6803529", "R-HSA-167242", "R-CEL-6782210", "R-HSA-8851708", "R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-RNO-76061", "R-CEL-112382", "R-HSA-9670095", "R-HSA-167160", "R-CEL-6782135", "R-DDI-77075", "R-SPO-73779", "R-MMU-73772", "R-MMU-72086", "R-DDI-113418", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-DME-5578749", "R-DME-73779", "R-DME-77075", "R-CEL-73772", "R-DME-9770562", "R-DME-73776", "R-MMU-6781823", "R-HSA-203927", "R-DDI-73772", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-HSA-73780", "R-MMU-73776", "R-DDI-76042", "R-CEL-72163", "R-HSA-167172", "R-SCE-73779", "R-RNO-113418", "R-HSA-76071", "R-DME-113418", "R-HSA-72203", "R-MMU-6796648", "R-RNO-76071", "R-HSA-9770562", "R-CEL-75955", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-SCE-6781823", "R-MMU-76071", "R-RNO-76066", "R-SCE-9018519", "R-HSA-73863", "R-RNO-77075", "R-HSA-167290", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-DME-76066", "R-CEL-9018519", "R-RNO-9770562", "R-DME-6782210", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-RNO-6807505", "R-MMU-72203", "R-RNO-674695", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-SPO-6807505", "R-RNO-73863", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-RNO-72165", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-SPO-73762", "R-RNO-6782210", "R-SPO-75953", "R-HSA-5601884", "R-SPO-113418", "R-MMU-5250924", "R-CEL-6807505", "R-DME-674695", "R-RNO-72203", "R-RNO-76042", "R-DME-9018519", "R-DDI-73779", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-CEL-113418", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-MMU-6807505", "R-RNO-5578749", "R-SCE-76042", "R-MMU-9018519", "R-CEL-6781823", "R-SPO-9770562", "R-DME-6807505", "R-DDI-6807505", "R-HSA-167200", "R-SCE-73762", "R-DME-72165", "R-RNO-112382", "R-SCE-674695", "R-MMU-6782210", "R-CEL-6796648", "R-RNO-75953", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-SCE-76066", "R-MMU-73762", "R-MMU-6782135", "R-HSA-76066", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-DDI-76061", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-SCE-6782210", "R-HSA-9918481", "R-RNO-6803529", "R-SCE-72203", "R-SCE-6796648", "R-SPO-72203", "R-RNO-72086", "R-SPO-77075", "R-RNO-73772", "R-RNO-6782135", "R-SCE-113418", "R-SCE-72086", "R-MMU-73863", "R-RNO-5250924", "R-HSA-6782135", "R-HSA-73762", "R-CEL-77075", "R-SCE-77075", "R-HSA-5250924", "R-DDI-75953", "R-SPO-6782135", "R-CEL-73762", "R-DME-73772", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-DME-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-72086:r:mRNA Capping", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-9770562:r:mRNA Polyadenylation", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-RNO-9770562:r:mRNA Polyadenylation", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Family"}, "IPR028364": {"description": "Ribosomal protein uL1/ribosomal biogenesis protein", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL1/biogenesis", "pathway_ids": ["R-HSA-5419276", 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"R-HSA-192823", "R-BTA-5389840", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DME-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DRE-975956", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-9937383", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-BTA-9954709", "R-DRE-6791226", "R-MMU-5419276", "R-BTA-5419276", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex 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"R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR028366": {"description": "PhoU", "go_ids": ["GO:0045936", "GO:0030643"], "go_terms": ["GO:0045936:negative regulation of phosphate metabolic process:P", "GO:0030643:intracellular phosphate ion homeostasis:P"], "name": "PhoU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028374": {"description": "FadR, C-terminal domain", "go_ids": ["GO:0019217", "GO:0000062"], "go_terms": ["GO:0019217:regulation of fatty acid metabolic process:P", "GO:0000062:fatty-acyl-CoA binding:F"], "name": "FadR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028375": {"description": "KA1 domain/Ssp2, C-terminal", "go_ids": [], "go_terms": [], "name": "KA1/Ssp2_C", "pathway_ids": ["R-MMU-9856649", "R-HSA-5674135", "R-HSA-6802952", "R-MMU-1632852", "R-MMU-6804756", "R-CEL-5673000", "R-HSA-5673000", "R-RNO-1632852", "R-HSA-9649948", "R-SPO-200425", "R-DDI-5673000", "R-SPO-163680", "R-MMU-5628897", "R-HSA-9613354", "R-CEL-9856649", "R-MMU-5620912", "R-HSA-6802955", "R-SCE-200425", "R-SSC-163680", "R-MMU-163680", "R-DDI-163680", "R-RNO-5673000", "R-HSA-9931269", "R-SSC-380972", "R-HSA-6802948", "R-MMU-200425", "R-CEL-5628897", "R-RNO-5628897", "R-MMU-5673000", "R-RNO-9931269", "R-DDI-380972", "R-RNO-5675221", "R-CEL-5674135", "R-RNO-9759194", 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"R-MMU-9648025", "R-HSA-9648025", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR028389": {"description": "Protection of telomeres protein 1", "go_ids": ["GO:0043047", "GO:0000723"], "go_terms": ["GO:0043047:single-stranded telomeric DNA binding:F", "GO:0000723:telomere maintenance:P"], "name": "POT1", "pathway_ids": ["R-GGA-174417", "R-MMU-174430", "R-MMU-110330", "R-HSA-171306", "R-HSA-174414", "R-GGA-174437", "R-MMU-2559586", "R-GGA-174411", "R-MMU-174417", "R-HSA-174430", "R-HSA-110328", "R-GGA-174414", "R-GGA-174430", "R-HSA-1221632", "R-HSA-174411", "R-MMU-110331", "R-MMU-9670095", "R-MMU-171319", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-GGA-418124", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-GGA-171319", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-GGA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-GGA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-GGA-174414:r:Processive synthesis on the C-strand of the telomere", "R-GGA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-GGA-418124:r:Telomere maintenance", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-GGA-171319:r:Telomere Extension By Telomerase", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Family"}, "IPR028391": {"description": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain", "go_ids": ["GO:0004435"], "go_terms": ["GO:0004435:phosphatidylinositol-4,5-bisphosphate phospholipase C activity:F"], "name": "PLC-delta1_cat", "pathway_ids": ["PWY-6367", "PWY-7039", "PWY-6351", "PWY-8052", "R-MMU-1855204", "R-BTA-1855204", "R-HSA-1855204", "R-RNO-1855204"], "pathways": ["PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol"], "type": "Domain"}, "IPR028422": {"description": "GREB1", "go_ids": [], "go_terms": [], "name": "GREB1", "pathway_ids": ["R-HSA-9018519", "R-MMU-9018519"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Family"}, "IPR028426": {"description": "Huntingtin family", "go_ids": [], "go_terms": [], "name": "Huntingtin_fam", "pathway_ids": ["R-HSA-9022692"], "pathways": ["R-HSA-9022692:r:Regulation of MECP2 expression and activity"], "type": "Family"}, "IPR028427": {"description": "Peptide methionine sulfoxide reductase MsrB", "go_ids": ["GO:0016671", "GO:0006979", "GO:0030091"], "go_terms": ["GO:0016671:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor:F", "GO:0006979:response to oxidative stress:P", "GO:0030091:protein repair:P"], "name": "Met_Sox_Rdtase_MsrB", "pathway_ids": ["R-MMU-5676934", "R-HSA-5676934", "R-DRE-5676934", "R-CEL-5676934", "R-DME-5676934", "R-RNO-5676934"], "pathways": ["R-MMU-5676934:r:Protein repair", "R-HSA-5676934:r:Protein repair", "R-DRE-5676934:r:Protein repair", "R-CEL-5676934:r:Protein repair", "R-DME-5676934:r:Protein repair", "R-RNO-5676934:r:Protein repair"], "type": "Family"}, "IPR028431": {"description": "NADP-reducing hydrogenase subunit HndA-like", "go_ids": [], "go_terms": [], "name": "NADP_DH_HndA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028433": {"description": "Parvin", "go_ids": ["GO:0030036", "GO:0003779", "GO:0007155"], "go_terms": ["GO:0030036:actin cytoskeleton organization:P", "GO:0003779:actin binding:F", "GO:0007155:cell adhesion:P"], "name": "Parvin", "pathway_ids": ["R-MMU-446353", "R-HSA-446353", "R-HSA-446343", "R-CEL-446388", "R-RNO-446388", "R-HSA-446388", "R-MMU-446343", "R-MMU-446388", "R-CEL-446353", "R-RNO-446343", "R-CEL-446343"], "pathways": ["R-MMU-446353:r:Cell-extracellular matrix interactions", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-CEL-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions"], "type": "Family"}, "IPR028435": {"description": "Plakophilin/Delta catenin", "go_ids": ["GO:0098609"], "go_terms": ["GO:0098609:cell-cell adhesion:P"], "name": "Plakophilin/d_Catenin", "pathway_ids": ["R-HSA-6798695", "R-RNO-6809371", "R-HSA-6809371", "R-HSA-9696270", "R-MMU-5218920", "R-DRE-6805567", "R-CEL-9764561", "R-CEL-6798695", "R-DRE-6809371", "R-HSA-9766229", "R-MMU-351906", "R-HSA-351906", "R-HSA-9764302", "R-MMU-9762292", "R-MMU-418990", "R-HSA-9696264", "R-HSA-8876493", "R-HSA-418990", "R-HSA-9764561", "R-HSA-5218920", "R-MMU-6809371", "R-MMU-9764561", "R-RNO-6805567", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-9833576", "R-MMU-9696264", "R-CEL-6809371", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-9766229", "R-MMU-6805567", "R-HSA-6805567", "R-CEL-5218920", "R-HSA-9696273"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-6805567:r:Keratinization", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-CEL-6798695:r:Neutrophil degranulation", "R-DRE-6809371:r:Formation of the cornified envelope", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-MMU-9762292:r:Regulation of CDH11 function", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-HSA-418990:r:Adherens junctions interactions", "R-HSA-9764561:r:Regulation of CDH1 Function", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-9764561:r:Regulation of CDH1 Function", "R-RNO-6805567:r:Keratinization", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9833576:r:CDH11 homotypic and heterotypic interactions", "R-MMU-9696264:r:RND3 GTPase cycle", "R-CEL-6809371:r:Formation of the cornified envelope", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-6805567:r:Keratinization", "R-HSA-6805567:r:Keratinization", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Family"}, "IPR028440": {"description": "Transcription factor TRPS1", "go_ids": ["GO:0003700", "GO:0005634"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C"], "name": "TRPS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028457": {"description": "ABI family", "go_ids": [], "go_terms": [], "name": "ABI", "pathway_ids": ["R-DDI-2029482", "R-HSA-5663213", "R-HSA-9664422", "R-DDI-5663213", "R-RNO-9013149", "R-HSA-2029482", "R-MMU-9013404", "R-MMU-4420097", "R-MMU-2029482", "R-DDI-9013149", "R-RNO-2029482", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-4420097", "R-MMU-5663213", "R-RNO-5663213", "R-RNO-9013423", "R-DDI-9013423", "R-DDI-9013404", "R-RNO-9013404", "R-MMU-9013149", "R-RNO-4420097"], "pathways": ["R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Family"}, "IPR028458": {"description": "Twinfilin", "go_ids": ["GO:0003779", "GO:0030837"], "go_terms": ["GO:0003779:actin binding:F", "GO:0030837:negative regulation of actin filament polymerization:P"], "name": "Twinfilin", "pathway_ids": ["R-MMU-9013418", "R-DME-9013418", "R-HSA-9013418", "R-HSA-9662360", "R-DDI-9013418", "R-RNO-9013418", "R-HSA-9662361", "R-XTR-9013418"], "pathways": ["R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-XTR-9013418:r:RHOBTB2 GTPase cycle"], "type": "Family"}, "IPR028472": {"description": "Protein phosphatase EYA", "go_ids": ["GO:0004725"], "go_terms": ["GO:0004725:protein tyrosine phosphatase activity:F"], "name": "EYA", "pathway_ids": ["R-HSA-9830674", "R-DME-5693565", "R-BTA-5693565", "R-HSA-5693565", "R-MMU-5693565"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Family"}, "IPR028540": {"description": "A-kinase anchor protein 12", "go_ids": ["GO:0141156", "GO:0090036", "GO:0051018"], "go_terms": ["GO:0141156:cAMP/PKA signal transduction:P", "GO:0090036:regulation of protein kinase C signaling:P", "GO:0051018:protein kinase A binding:F"], "name": "AKAP12", "pathway_ids": ["R-HSA-9013405", "R-HSA-9035034", "R-RNO-9035034", "R-MMU-9035034"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle"], "type": "Family"}, "IPR028544": {"description": "Protein CASC3", "go_ids": ["GO:0006397", "GO:0035145", "GO:0003723"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:0035145:exon-exon junction complex:C", "GO:0003723:RNA binding:F"], "name": "CASC3", "pathway_ids": ["R-RNO-975957", "R-BTA-975957", "R-MMU-72163", "R-HSA-9010553", "R-MMU-975957", "R-BTA-73856", "R-HSA-73856", "R-XTR-159236", "R-XTR-72163", "R-HSA-72187", "R-DRE-975957", "R-MMU-73856", "R-RNO-72163", "R-MMU-159236", "R-RNO-73856", "R-DRE-72163", "R-HSA-72163", "R-DRE-159236", "R-HSA-975957", "R-XTR-975957", "R-DRE-73856", "R-MMU-72187", "R-RNO-159236", "R-BTA-159236", "R-HSA-159236", "R-BTA-72163"], "pathways": ["R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72187:r:mRNA 3'-end processing", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR028565": {"description": "Mu homology domain", "go_ids": [], "go_terms": [], "name": "MHD", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-SPO-437239", "R-SCE-8856828", "R-XTR-8856825", "R-HSA-9918485", "R-DDI-8856825", "R-HSA-6811434", "R-RNO-177504", "R-DDI-8964038", "R-HSA-5140745", "R-GGA-196025", "R-GGA-5140745", "R-MMU-6811434", "R-DDI-6798695", "R-MMU-196025", "R-BTA-5099900", "R-HSA-432720", "R-HSA-437239", "R-CEL-6807878", "R-MMU-5140745", "R-BTA-177504", "R-HSA-164939", "R-HSA-164940", "R-SPO-8866427", "R-CEL-8964038", "R-SPO-190873", "R-SCE-196025", "R-SPO-196025", "R-CEL-8856825", "R-SCE-8866427", "R-BTA-6811434", "R-RNO-6798695", "R-GGA-6807878", "R-HSA-190873", "R-CEL-432720", "R-SCE-6798695", "R-DDI-437239", "R-DDI-6811434", "R-BTA-6807878", "R-MMU-190873", "R-SCE-432720", "R-DDI-8866427", "R-MMU-2132295", "R-MMU-8964038", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-BTA-2132295", "R-HSA-196025", "R-BTA-8856828", "R-CEL-8856828", "R-HSA-416993", "R-RNO-2132295", "R-MMU-437239", "R-GGA-8856825", "R-RNO-437239", "R-BTA-432720", "R-HSA-167590", "R-HSA-5099900", "R-GGA-190873", "R-CEL-3928665", "R-HSA-8866427", "R-GGA-8866427", "R-HSA-8856825", "R-HSA-3928665", "R-GGA-3928665", "R-BTA-5140745", "R-SCE-190873", "R-HSA-8964038", "R-CEL-6811434", "R-RNO-416993", "R-HSA-182218", "R-HSA-6798695", "R-BTA-196025", "R-DRE-8964038", "R-HSA-8856828", "R-CEL-6798695", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-432722", "R-BTA-6798695", "R-RNO-8964038", "R-BTA-190873", "R-GGA-437239", "R-GGA-8964038", "R-RNO-196025", "R-SPO-8856825", "R-XTR-5099900", "R-DDI-8856828", "R-XTR-5140745", "R-XTR-8866427", "R-RNO-8866427", "R-GGA-8856828", "R-RNO-432722", "R-SCE-6811434", "R-RNO-432720", "R-DRE-416993", "R-CEL-8866427", "R-GGA-416993", "R-MMU-8866427", "R-SCE-8856825", "R-MMU-6798695", "R-XTR-437239", "R-DRE-196025", "R-HSA-2132295", "R-SPO-6798695", "R-MMU-8856825", "R-MMU-432722", "R-CEL-437239", "R-CEL-190873", "R-BTA-416993", "R-MMU-6807878", "R-SPO-8964038", "R-CEL-5140745", "R-RNO-190873", "R-DME-8856828", "R-DRE-5099900", "R-MMU-432720", "R-RNO-5099900", "R-SCE-8964038", "R-SPO-432720", "R-HSA-432722", "R-MMU-416993", "R-DRE-8856825", "R-XTR-196025", "R-XTR-8856828", "R-DME-8856825", "R-SCE-6807878", "R-RNO-8856825", "R-RNO-6811434", "R-HSA-390471", "R-RNO-6807878", "R-CEL-196025", "R-DDI-432720", "R-HSA-6807878", "R-SPO-8856828", "R-DRE-177504", "R-HSA-9679191", "R-HSA-177504", "R-BTA-8856825", "R-GGA-2132295", "R-GGA-177504", "R-BTA-8964038", "R-DDI-6807878", "R-SCE-437239", "R-MMU-177504", "R-BTA-432722", "R-XTR-8964038", "R-GGA-6811434"], "pathways": ["R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-437239:r:Recycling pathway of L1", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DDI-8964038:r:LDL clearance", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-GGA-196025:r:Formation of annular gap junctions", "R-GGA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-196025:r:Formation of annular gap junctions", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-437239:r:Recycling pathway of L1", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-HSA-164939:r:Nef mediated downregulation of CD28 cell surface expression", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-CEL-8964038:r:LDL clearance", "R-SPO-190873:r:Gap junction degradation", "R-SCE-196025:r:Formation of annular gap junctions", "R-SPO-196025:r:Formation of annular gap junctions", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6798695:r:Neutrophil degranulation", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-437239:r:Recycling pathway of L1", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-MMU-190873:r:Gap junction degradation", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-8964038:r:LDL clearance", "R-BTA-437239:r:Recycling pathway of L1", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-HSA-196025:r:Formation of annular gap junctions", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-437239:r:Recycling pathway of L1", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-437239:r:Recycling pathway of L1", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-GGA-190873:r:Gap junction degradation", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-190873:r:Gap junction degradation", "R-HSA-8964038:r:LDL clearance", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-196025:r:Formation of annular gap junctions", "R-DRE-8964038:r:LDL clearance", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-8964038:r:LDL clearance", "R-BTA-190873:r:Gap junction degradation", "R-GGA-437239:r:Recycling pathway of L1", "R-GGA-8964038:r:LDL clearance", "R-RNO-196025:r:Formation of annular gap junctions", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-XTR-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-XTR-8866427:r:VLDLR internalisation and degradation", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DRE-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-8866427:r:VLDLR internalisation and degradation", "R-GGA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-XTR-437239:r:Recycling pathway of L1", "R-DRE-196025:r:Formation of annular gap junctions", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-437239:r:Recycling pathway of L1", "R-CEL-190873:r:Gap junction degradation", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-SPO-8964038:r:LDL clearance", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-190873:r:Gap junction degradation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-DRE-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SCE-8964038:r:LDL clearance", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-196025:r:Formation of annular gap junctions", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-CEL-196025:r:Formation of annular gap junctions", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-DRE-177504:r:Retrograde neurotrophin signalling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-2132295:r:MHC class II antigen presentation", "R-GGA-177504:r:Retrograde neurotrophin signalling", "R-BTA-8964038:r:LDL clearance", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-XTR-8964038:r:LDL clearance", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR028598": {"description": "WD repeat BOP1/Erb1", "go_ids": ["GO:0042254"], "go_terms": ["GO:0042254:ribosome biogenesis:P"], "name": "BOP1/Erb1", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DRE-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR028611": {"description": "Tat proofreading chaperone DmsD", "go_ids": ["GO:0005048"], "go_terms": ["GO:0005048:signal sequence receptor activity:F"], "name": "DmsD_chaperone", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028616": {"description": "Regulator of RpoS", "go_ids": [], "go_terms": [], "name": "RssB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028621": {"description": "ATP-dependent RNA helicase SrmB", "go_ids": ["GO:0000027", "GO:0003724"], "go_terms": ["GO:0000027:ribosomal large subunit assembly:P", "GO:0003724:RNA helicase activity:F"], "name": "DEAD_helicase_SrmB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028623": {"description": "HNS-dependent expression B", "go_ids": ["GO:0009268"], "go_terms": ["GO:0009268:response to pH:P"], "name": "HdeB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028629": {"description": "CRISPR-associated endonuclease Cas9", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "Cas9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR028631": {"description": "Adrenocortical dysplasia protein", "go_ids": ["GO:0016233", "GO:0070187", "GO:0000783", "GO:0000723"], "go_terms": ["GO:0016233:telomere capping:P", "GO:0070187:shelterin complex:C", "GO:0000783:nuclear telomere cap complex:C", "GO:0000723:telomere maintenance:P"], "name": "ACD", "pathway_ids": ["R-RNO-2559586", "R-MMU-174430", "R-RNO-174437", "R-MMU-110330", "R-HSA-171306", "R-HSA-174414", "R-MMU-2559586", "R-MMU-174417", "R-RNO-174430", "R-HSA-174430", "R-RNO-110331", "R-HSA-110328", "R-HSA-1221632", "R-HSA-174411", "R-RNO-171319", "R-MMU-110331", "R-MMU-9670095", "R-MMU-171319", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-MMU-174437", "R-RNO-110330", "R-RNO-174417", "R-HSA-110329", "R-HSA-110330", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586", "R-RNO-174411", "R-RNO-174414"], "pathways": ["R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere"], "type": "Family"}, "IPR028641": {"description": "Protein RCC2", "go_ids": [], "go_terms": [], "name": "RCC2", "pathway_ids": ["R-MMU-2500257", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-68877", "R-DRE-2500257", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-HSA-5663220", "R-DRE-5663220", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-HSA-9648025", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached 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"R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-354192:r:Integrin signaling", "R-MMU-3000157:r:Laminin interactions", "R-BTA-8874081:r:MET activates PTK2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-210991:r:Basigin interactions", "R-HSA-1566977:r:Fibronectin matrix formation", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-DME-446107:r:Type I hemidesmosome assembly", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-9830674:r:Formation of the ureteric bud", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-445355:r:Smooth Muscle Contraction", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Homologous_superfamily"}, "IPR028995": {"description": "Glycoside hydrolase families 57/38, central domain superfamily", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_57/38_cen_sf", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", 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"R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DDI-8853383:r:Lysosomal oligosaccharide catabolism", "R-SCE-8853383:r:Lysosomal oligosaccharide catabolism"], "type": "Homologous_superfamily"}, "IPR028996": {"description": "Ganglioside GM2 activator", "go_ids": ["GO:0006689", "GO:0008047"], "go_terms": ["GO:0006689:ganglioside catabolic process:P", "GO:0008047:enzyme activator activity:F"], "name": "GM2-AP", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-MMU-9840310", "R-HSA-9840310"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Family"}, "IPR028997": {"description": "PA2201-like, N-terminal", "go_ids": [], "go_terms": [], "name": "PA2201-like_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR028998": {"description": "Ribosome maturation factor RimP, C-terminal", "go_ids": [], "go_terms": [], "name": "RimP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR028999": {"description": "Haemocyanin, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Beta-sandwich_Haemocyanin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029000": {"description": "Cyclophilin-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Cyclophilin-like_dom_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-180910", "R-BTA-8939211", "R-MMU-210991", "R-DME-6781823", "R-MMU-2467813", "R-CEL-6798695", "R-MMU-4570464", "R-DME-72163", "R-RNO-72163", "R-BTA-6798695", "R-DDI-6782210", "R-MMU-68877", "R-HSA-170822", "R-DDI-72163", "R-HSA-1650814", "R-HSA-164525", "R-HSA-6781823", "R-MMU-159230", "R-HSA-159230", "R-MMU-4551638", "R-CEL-8939211", "R-HSA-3371453", "R-HSA-8939211", "R-RNO-8939211", "R-HSA-4570464", "R-HSA-4551638", "R-HSA-210991", "R-DME-6782135", "R-HSA-173107", "R-BTA-72163", 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"R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", 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Machinery", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-HSA-114608:r:Platelet degranulation", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-162592:r:Integration of provirus", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-210991:r:Basigin interactions", "R-CEL-210991:r:Basigin interactions", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-SCE-8939211:r:ESR-mediated signaling", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-180746:r:Nuclear import of Rev protein", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Homologous_superfamily"}, "IPR029001": {"description": "Inosine triphosphate pyrophosphatase-like", "go_ids": [], "go_terms": [], "name": "ITPase-like_fam", "pathway_ids": ["R-GGA-74259", "R-DDI-9755088", "R-SCE-9755088", "R-CEL-74259", "R-RNO-9755088", "R-RNO-74259", "R-PFA-9755088", "R-GGA-9755088", "R-CEL-9755088", "R-MMU-9755088", "R-BTA-9755088", "R-BTA-74259", "R-HSA-74259", "R-DME-74259", "R-DRE-74259", "R-SPO-9755088", "R-DRE-9755088", "R-MMU-74259", "R-SCE-74259", "R-DME-9755088", "R-SPO-74259", "R-HSA-9755088", "R-PFA-74259", "R-DDI-74259"], "pathways": ["R-GGA-74259:r:Purine catabolism", "R-DDI-9755088:r:Ribavirin ADME", "R-SCE-9755088:r:Ribavirin ADME", "R-CEL-74259:r:Purine catabolism", "R-RNO-9755088:r:Ribavirin ADME", "R-RNO-74259:r:Purine catabolism", "R-PFA-9755088:r:Ribavirin ADME", "R-GGA-9755088:r:Ribavirin ADME", "R-CEL-9755088:r:Ribavirin ADME", "R-MMU-9755088:r:Ribavirin ADME", "R-BTA-9755088:r:Ribavirin ADME", "R-BTA-74259:r:Purine catabolism", "R-HSA-74259:r:Purine catabolism", "R-DME-74259:r:Purine catabolism", "R-DRE-74259:r:Purine catabolism", "R-SPO-9755088:r:Ribavirin ADME", "R-DRE-9755088:r:Ribavirin ADME", "R-MMU-74259:r:Purine catabolism", "R-SCE-74259:r:Purine catabolism", "R-DME-9755088:r:Ribavirin ADME", "R-SPO-74259:r:Purine catabolism", "R-HSA-9755088:r:Ribavirin ADME", "R-PFA-74259:r:Purine catabolism", "R-DDI-74259:r:Purine catabolism"], "type": "Homologous_superfamily"}, "IPR029002": {"description": "Phospholipase C/D", "go_ids": [], "go_terms": [], "name": "PLPC/GPLD1", "pathway_ids": ["R-DDI-163125", "R-MMU-163125", "R-SCE-163125", "R-RNO-163125", "R-HSA-163125"], "pathways": ["R-DDI-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-SCE-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Domain"}, "IPR029003": {"description": "CENP-S/Mhf1", "go_ids": ["GO:0071821"], "go_terms": ["GO:0071821:FANCM-MHF complex:C"], "name": "CENP-S/Mhf1", "pathway_ids": ["R-HSA-606279", "R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-9833482", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-MMU-606279", "R-BTA-5663220", "R-HSA-9648025", "R-MMU-68877", "R-BTA-606279", "R-HSA-6783310", "R-MMU-6783310", "R-MMU-9833482", "R-BTA-2467813", "R-HSA-68877", "R-BTA-6783310", "R-BTA-2500257", "R-HSA-5663220", "R-BTA-9648025", "R-BTA-141444", "R-BTA-9833482", "R-MMU-5663220"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the 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"R-HSA-2408557", "R-HSA-9633012", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-CEL-9954709", "R-DME-975956", "R-CEL-1799339", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72706", "R-HSA-72689", "R-HSA-72764", "R-MMU-156827", "R-CEL-156827", "R-RNO-6791226", "R-HSA-975957", "R-DME-9954714", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-HSA-9954714", "R-DME-975957", "R-DDI-156827", "R-SPO-72689", "R-RNO-9954714", "R-MMU-1799339", "R-CEL-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-CEL-975957", "R-MMU-72689", "R-SPO-9954714", "R-HSA-9010553", "R-RNO-72706", "R-SPO-975957", "R-HSA-156827", "R-DDI-72689", "R-RNO-72689", "R-RNO-1799339", "R-MMU-9954709", "R-DME-9954716", "R-DME-72706", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-HSA-9954709"], "pathways": ["R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-192823:r:Viral mRNA Translation", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR029005": {"description": "LIM-domain binding protein/SEUSS", "go_ids": [], "go_terms": [], "name": "LIM-bd/SEUSS", "pathway_ids": ["R-HSA-9752946", "R-GGA-8939236", "R-HSA-9733709", "R-HSA-9010553", "R-DME-8939236", "R-DRE-8939236", "R-HSA-8939236", "R-XTR-8939236", "R-MMU-8939236"], "pathways": ["R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DRE-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-XTR-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "type": "Family"}, "IPR029006": {"description": "ADF-H/Gelsolin-like domain superfamily", "go_ids": [], "go_terms": [], "name": "ADF-H/Gelsolin-like_dom_sf", "pathway_ids": ["R-HSA-6798695", "R-MMU-204005", "R-SPO-6798695", "R-HSA-2132295", "R-SSC-6798695", "R-HSA-9013405", "R-HSA-9705671", "R-HSA-9013418", "R-HSA-9013422", "R-DDI-983170", "R-MMU-5694530", "R-HSA-977225", "R-CEL-6798695", "R-SCE-6798695", "R-SCE-204005", "R-DRE-204005", "R-BTA-6798695", "R-HSA-5694530", "R-HSA-3928662", "R-HSA-6794361", "R-HSA-114608", "R-DRE-2132295", "R-SCE-5694530", "R-HSA-9662360", "R-MMU-2132295", "R-DME-264870", "R-XTR-9013418", "R-BTA-204005", "R-BTA-2132295", "R-SPO-983170", "R-SCE-983170", "R-RNO-9013418", "R-HSA-1655829", "R-DDI-6798695", "R-DDI-204005", "R-XTR-204005", "R-DDI-5694530", "R-DME-6798695", "R-HSA-9662361", "R-XTR-5694530", "R-SPO-204005", "R-HSA-8950505", "R-SPO-5694530", "R-HSA-2029482", "R-DRE-5694530", "R-DRE-983170", "R-DME-9013418", "R-BTA-983170", "R-HSA-204005", "R-HSA-983170", "R-BTA-5694530", "R-HSA-399954", "R-MMU-264870", "R-MMU-983170", "R-MMU-6798695", "R-SSC-264870", "R-RNO-264870", "R-HSA-264870", "R-MMU-9013418", "R-DDI-9013418", "R-RNO-6798695", "R-HSA-9013407", "R-HSA-5627117"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-977225:r:Amyloid fiber formation", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-114608:r:Platelet degranulation", "R-DRE-2132295:r:MHC class II antigen presentation", "R-SCE-5694530:r:Cargo concentration in the ER", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-XTR-9013418:r:RHOBTB2 GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-XTR-204005:r:COPII-mediated vesicle transport", "R-DDI-5694530:r:Cargo concentration in the ER", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-XTR-5694530:r:Cargo concentration in the ER", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-SPO-5694530:r:Cargo concentration in the ER", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-5694530:r:Cargo concentration in the ER", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-BTA-5694530:r:Cargo concentration in the ER", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Homologous_superfamily"}, "IPR029008": {"description": "ER membrane protein complex subunit 6-like", "go_ids": [], "go_terms": [], "name": "EMC6-like", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR029009": {"description": "Allosteric substrate binding domain superfamily", "go_ids": [], "go_terms": [], "name": "ASB_dom_sf", "pathway_ids": ["PWY-8010", "R-MMU-977347", "R-RNO-977347", "R-SSC-977347", "R-HSA-977347"], "pathways": ["PWY-8010:t:L-cysteine biosynthesis IX (Trichomonas vaginalis)", "R-MMU-977347:r:Serine metabolism", "R-RNO-977347:r:Serine metabolism", "R-SSC-977347:r:Serine metabolism", "R-HSA-977347:r:Serine metabolism"], "type": "Homologous_superfamily"}, "IPR029010": {"description": "ThuA-like domain", "go_ids": [], "go_terms": [], "name": "ThuA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029012": {"description": "Helix hairpin bin domain superfamily", "go_ids": [], "go_terms": [], "name": "Helix_hairpin_bin_sf", "pathway_ids": ["R-HSA-9610379", "R-DDI-6782135", "R-RNO-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-917729", "R-MMU-72163", "R-RNO-6782135", "R-DDI-6781823", "R-RNO-72163", "R-DDI-6782210", "R-HSA-6782135", "R-CEL-6782210", "R-DDI-72163", "R-HSA-162588", "R-HSA-6781823", "R-CEL-6781823", "R-HSA-917729", "R-RNO-6782210", "R-HSA-72163", "R-MMU-6781823", "R-SPO-6782210", "R-CEL-6782135", "R-HSA-6782210", "R-HSA-174490", "R-MMU-6782210", "R-HSA-9615710", "R-HSA-9609523", "R-SPO-6782135", "R-SCE-6782210", "R-SPO-72163", "R-CEL-72163", "R-DDI-917729", "R-HSA-9918481", "R-SCE-6782135"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Homologous_superfamily"}, "IPR029013": {"description": "HP0062-like domain superfamily", "go_ids": [], "go_terms": [], "name": "HP0062-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR029014": {"description": "[NiFe]-hydrogenase, large subunit", "go_ids": [], "go_terms": [], "name": "NiFe-Hase_large", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-CEL-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198", "R-MMU-611105", "R-BTA-6799198", "R-DDI-6799198", "R-BTA-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-CEL-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Homologous_superfamily"}, "IPR029016": {"description": "GAF-like domain superfamily", "go_ids": [], "go_terms": [], "name": "GAF-like_dom_sf", "pathway_ids": ["R-RNO-418555", "R-HSA-9013422", "R-HSA-445355", "R-RNO-9013422", "R-HSA-2514859", "R-CEL-418457", "R-MMU-4086398", "R-RNO-2485179", "R-HSA-2485179", "R-HSA-418555", "R-RNO-2514859", "R-CFA-445355", "R-MMU-445355", "R-DME-9013422", "R-DME-445355", "R-MMU-418457", "R-BTA-418457", "R-CEL-418555", "R-BTA-9013422", "R-CFA-418457", "R-RNO-4086398", "R-HSA-418457", "R-BTA-445355", "R-MMU-9013422", "R-RNO-445355", "R-DME-418457", "R-CFA-9013422", "R-MMU-2514859", "R-RNO-418457", "R-MMU-2485179", "R-HSA-4086398", "R-CFA-2485179", "R-CFA-4086398", "R-MMU-418555"], "pathways": ["R-RNO-418555:r:G alpha (s) signalling events", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-418457:r:cGMP effects", "R-MMU-4086398:r:Ca2+ pathway", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CFA-445355:r:Smooth Muscle Contraction", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-DME-445355:r:Smooth Muscle Contraction", "R-MMU-418457:r:cGMP effects", "R-BTA-418457:r:cGMP effects", "R-CEL-418555:r:G alpha (s) signalling events", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-418457:r:cGMP effects", "R-RNO-4086398:r:Ca2+ pathway", "R-HSA-418457:r:cGMP effects", "R-BTA-445355:r:Smooth Muscle Contraction", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-445355:r:Smooth Muscle Contraction", "R-DME-418457:r:cGMP effects", "R-CFA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-418457:r:cGMP effects", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-HSA-4086398:r:Ca2+ pathway", "R-CFA-2485179:r:Activation of the phototransduction cascade", "R-CFA-4086398:r:Ca2+ pathway", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Homologous_superfamily"}, "IPR029017": {"description": "Enolase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Enolase-like_N", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-2221", "PWY-1622", "PWY-7124", "PWY-6886", "PWY-6142", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-MMU-70171", "R-DRE-70263", "R-SCE-70171", "R-BTA-70171", "R-DME-70171", "R-PFA-70263", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-DME-70263", "R-DDI-70263", "R-PFA-70171", "R-RNO-70171", "R-GGA-352882", "R-HSA-70263", "R-CEL-70263", "R-BTA-70263", "R-SPO-70263", "R-SCE-70263", "R-DRE-70171", "R-HSA-9636667", "R-HSA-70171", "R-SPO-70171", "R-RNO-70263"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-DRE-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-PFA-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-PFA-70171:r:Glycolysis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-DRE-70171:r:Glycolysis", "R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR029018": {"description": "Beta-hexosaminidase-like, domain 2", "go_ids": [], "go_terms": [], "name": "Hex-like_dom2", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-7883", "R-DDI-9840310", "R-HSA-2024101", "R-HSA-6798695", "R-MMU-9840310", "R-DDI-6798695", "R-RNO-9840310", "R-CEL-2024101", "R-HSA-9840310", "R-CEL-6798695", "R-HSA-2022857", "R-HSA-3656234", "R-HSA-2160916", "R-MMU-2160916", "R-HSA-3656248", "R-CEL-2160916", "R-RNO-2022857", "R-MMU-2022857", "R-HSA-2206282", "R-BTA-9840310", "R-CEL-2022857", "R-CEL-9840310", "R-RNO-2024101", "R-HSA-2024096", "R-BTA-2160916", "R-DDI-2022857", "R-MMU-2024101", "R-MMU-6798695", "R-DDI-2160916", "R-DDI-2024101", "R-RNO-2160916", "R-BTA-2024101", "R-RNO-6798695", "R-BTA-2022857"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-7883:t:peptidoglycan recycling II", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-CEL-2024101:r:CS/DS degradation", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-2022857:r:Keratan sulfate degradation", "R-HSA-3656234:r:Defective HEXA causes GM2G1 (Hyaluronan metabolism)", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-3656248:r:Defective HEXB causes GM2G2 (Hyaluronan metabolism)", "R-CEL-2160916:r:Hyaluronan degradation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-2206282:r:MPS IIIB - Sanfilippo syndrome B", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-CEL-2022857:r:Keratan sulfate degradation", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-2024096:r:HS-GAG degradation", "R-BTA-2160916:r:Hyaluronan degradation", "R-DDI-2022857:r:Keratan sulfate degradation", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-2160916:r:Hyaluronan degradation", "R-DDI-2024101:r:CS/DS degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-2022857:r:Keratan sulfate degradation"], "type": "Homologous_superfamily"}, "IPR029019": {"description": "Beta-hexosaminidase, eukaryotic type, N-terminal", "go_ids": [], "go_terms": [], "name": "HEX_eukaryotic_N", "pathway_ids": ["PWY-7822", "PWY-6902", "PWY-7883", "R-DDI-9840310", "R-HSA-2024101", "R-HSA-6798695", "R-MMU-9840310", "R-DDI-6798695", "R-RNO-9840310", "R-CEL-2024101", "R-HSA-9840310", "R-CEL-6798695", "R-HSA-2022857", "R-HSA-3656234", "R-HSA-2160916", "R-MMU-2160916", "R-HSA-3656248", "R-CEL-2160916", "R-RNO-2022857", "R-MMU-2022857", "R-BTA-9840310", "R-CEL-2022857", "R-CEL-9840310", "R-RNO-2024101", "R-BTA-2160916", "R-DDI-2022857", "R-MMU-2024101", "R-MMU-6798695", "R-DDI-2160916", "R-DDI-2024101", "R-RNO-2160916", "R-BTA-2024101", "R-RNO-6798695", "R-BTA-2022857"], "pathways": ["PWY-7822:t:chitin degradation III (Serratia)", "PWY-6902:t:chitin degradation II (Vibrio)", "PWY-7883:t:peptidoglycan recycling II", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-CEL-2024101:r:CS/DS degradation", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-2022857:r:Keratan sulfate degradation", "R-HSA-3656234:r:Defective HEXA causes GM2G1 (Hyaluronan metabolism)", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-3656248:r:Defective HEXB causes GM2G2 (Hyaluronan metabolism)", "R-CEL-2160916:r:Hyaluronan degradation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-CEL-2022857:r:Keratan sulfate degradation", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-RNO-2024101:r:CS/DS degradation", "R-BTA-2160916:r:Hyaluronan degradation", "R-DDI-2022857:r:Keratan sulfate degradation", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-2160916:r:Hyaluronan degradation", "R-DDI-2024101:r:CS/DS degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-2022857:r:Keratan sulfate degradation"], "type": "Domain"}, "IPR029020": {"description": "Ammonium/urea transporter", "go_ids": [], "go_terms": [], "name": "Ammonium/urea_transptr", "pathway_ids": ["R-RNO-444411", "R-MMU-1237044", "R-MMU-549127", "R-DDI-1247673", "R-HSA-5619042", "R-HSA-9037628", "R-HSA-1247673", "R-RNO-1237044", "R-RNO-1247673", "R-MMU-444411", "R-BTA-549127", "R-MMU-1247673", "R-BTA-444411", "R-HSA-1237044", "R-DDI-1237044", "R-HSA-444411", "R-DRE-444411", "R-DDI-444411", "R-HSA-549127", "R-GGA-444411", "R-CFA-1247673", "R-CFA-444411", "R-RNO-549127", "R-XTR-444411", "R-CFA-1237044"], "pathways": ["R-RNO-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-DDI-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-5619042:r:Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)", "R-HSA-9037628:r:Rhesus blood group biosynthesis", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-MMU-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-BTA-549127:r:SLC-mediated transport of organic cations", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DDI-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-DRE-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-DDI-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-HSA-549127:r:SLC-mediated transport of organic cations", "R-GGA-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-CFA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-CFA-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-RNO-549127:r:SLC-mediated transport of organic cations", "R-XTR-444411:r:Rhesus glycoproteins mediate ammonium transport", "R-CFA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen"], "type": "Homologous_superfamily"}, "IPR029021": {"description": "Protein-tyrosine phosphatase-like", "go_ids": [], "go_terms": [], "name": "Prot-tyrosine_phosphatase-like", "pathway_ids": ["R-HSA-9725371", "R-MMU-77075", "R-MMU-5654727", "R-RNO-389948", "R-RNO-5654733", "R-RNO-983695", "R-SPO-1660517", "R-MMU-9696273", "R-HSA-2173788", "R-RNO-9833482", "R-HSA-9702518", "R-DME-210688", "R-HSA-391160", "R-HSA-186797", "R-CEL-8948747", "R-HSA-6798695", "R-MMU-1433559", "R-RNO-877300", "R-HSA-180292", "R-BTA-202670", "R-HSA-5689896", "R-HSA-8856828", "R-HSA-166016", "R-CEL-6798695", "R-CFA-1660499", "R-HSA-112411", "R-MMU-1660516", "R-SPO-1660516", "R-HSA-5654693", "R-MMU-8865999", "R-MMU-432142", "R-RNO-912526", "R-HSA-936964", "R-CEL-5673001", "R-MMU-5654695", "R-RNO-202427", "R-GGA-5654693", "R-SCE-1483248", "R-DRE-1483248", "R-HSA-1855183", "R-SPO-176407", "R-HSA-77075", "R-RNO-8865999", "R-RNO-5673001", "R-RNO-432722", "R-GGA-5654720", "R-DDI-1483248", "R-MMU-1433557", "R-HSA-1483248", "R-MMU-180292", "R-HSA-210993", "R-DDI-8948751", "R-HSA-8876198", "R-HSA-1660516", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-MMU-8876198", "R-HSA-1632852", "R-MMU-6798695", "R-MMU-202427", "R-MMU-8875513", "R-MMU-2173788", "R-SCE-5687128", "R-HSA-1257604", "R-MMU-1660517", "R-DRE-1660516", "R-MMU-416700", "R-CEL-5689896", "R-SPO-1632852", "R-MMU-5654710", "R-RNO-432142", "R-DRE-1660499", "R-MMU-8863795", "R-SPO-6798695", "R-BTA-1660516", "R-RNO-9674555", "R-SCE-1855204", "R-HSA-1660517", "R-CFA-8948751", "R-DDI-8948747", "R-DDI-1660499", "R-MMU-112411", "R-RNO-1295596", "R-RNO-1059683", "R-RNO-109704", "R-HSA-1660499", "R-HSA-375165", "R-HSA-1483148", "R-CFA-5689880", "R-DRE-77075", "R-GGA-186763", "R-HSA-210990", "R-HSA-416700", "R-RNO-1660516", "R-HSA-9035034", "R-RNO-110056", "R-MMU-110056", "R-HSA-432722", "R-HSA-176407", "R-GGA-1257604", "R-RNO-5654706", "R-MMU-389948", "R-BTA-1483248", "R-CFA-8948747", "R-HSA-9645135", "R-CEL-5675221", "R-HSA-5654706", "R-DDI-1660516", "R-DRE-72086", "R-RNO-982772", "R-DME-877312", "R-HSA-1660514", "R-CEL-77075", "R-DDI-202670", "R-HSA-186763", "R-GGA-5654732", "R-MMU-1059683", "R-HSA-9652817", "R-HSA-5654710", "R-RNO-1855204", "R-MMU-5654733", "R-RNO-5654700", "R-HSA-389948", "R-MMU-912694", "R-HSA-202424", "R-SCE-202424", "R-RNO-449836", "R-DDI-5689896", "R-HSA-9607240", "R-RNO-8948751", "R-MMU-9674555", "R-HSA-9833482", "R-MMU-114604", "R-HSA-5689880", "R-HSA-3000178", "R-GGA-8865999", "R-MMU-210990", "R-MMU-210993", "R-RNO-1433559", "R-MMU-5689896", "R-RNO-8854691", "R-RNO-877312", "R-GGA-5654706", "R-HSA-202427", "R-RNO-1632852", "R-MMU-5654706", "R-RNO-6811558", "R-RNO-210990", "R-CFA-199418", "R-HSA-8853659", "R-HSA-199418", "R-CEL-112409", "R-CEL-388844", "R-BTA-1660517", "R-MMU-5673001", "R-HSA-2586552", "R-MMU-449836", "R-HSA-114604", "R-GGA-5654689", "R-CEL-1855204", "R-MMU-77387", "R-HSA-182971", "R-RNO-5654732", "R-RNO-210993", "R-HSA-5654727", "R-HSA-5654689", "R-SCE-202670", "R-MMU-5690714", "R-RNO-5689880", "R-DRE-8849932", "R-HSA-9696264", "R-BTA-5675221", "R-DME-5675221", "R-HSA-1433559", "R-HSA-1295596", "R-HSA-112409", "R-GGA-389948", "R-HSA-167160", "R-CEL-1660517", "R-MMU-9851151", "R-HSA-8986944", "R-SPO-1483248", "R-MMU-5687128", "R-BTA-77387", "R-CEL-199418", "R-MMU-186797", "R-RNO-6798695", "R-MMU-5675221", "R-MMU-9860927", "R-CEL-8849932", "R-SCE-1660516", "R-CEL-1660516", "R-DME-5673001", "R-HSA-9705671", "R-RNO-9851151", "R-DDI-199418", "R-SCE-6798695", "R-MMU-8934593", "R-DRE-1660517", "R-MMU-388844", "R-RNO-5690714", "R-MMU-512988", "R-HSA-1250196", "R-MMU-877312", "R-MMU-202424", "R-HSA-389513", "R-DDI-1632852", "R-MMU-109704", "R-GGA-210993", "R-RNO-416700", "R-BTA-388844", "R-HSA-8943723", "R-DME-8873719", "R-SPO-1660514", "R-MMU-9927353", "R-SCE-1660499", "R-HSA-5654712", "R-MMU-9706369", "R-HSA-5690714", "R-HSA-9636569", "R-MMU-1660499", "R-MMU-8873719", "R-CEL-5689880", "R-MMU-5654726", "R-RNO-6807004", "R-GGA-5654712", "R-RNO-5654695", "R-RNO-1660499", "R-HSA-9634285", "R-MMU-8856828", "R-DDI-8873719", "R-MMU-5654720", "R-MMU-6811558", "R-HSA-77387", "R-MMU-1632852", "R-GGA-5654733", "R-MMU-8948751", "R-SPO-1660499", "R-RNO-512988", "R-GGA-5654695", "R-DRE-388844", "R-CEL-202670", "R-MMU-202430", "R-HSA-5654695", "R-DDI-202424", "R-MMU-5689880", "R-MMU-201556", "R-DDI-1855204", "R-HSA-8863795", "R-MMU-112409", "R-SCE-1660517", "R-DME-210693", "R-RNO-375165", "R-HSA-512988", "R-HSA-8875513", "R-CEL-182971", "R-MMU-186763", "R-DDI-6798695", "R-MMU-9035034", "R-GGA-437980", "R-HSA-202670", "R-HSA-1170546", "R-HSA-983695", "R-GGA-1059683", "R-HSA-432720", "R-MMU-8948747", "R-GGA-5654726", "R-HSA-9927353", "R-RNO-5675221", "R-RNO-936964", "R-HSA-8934593", "R-CEL-1483248", "R-RNO-202670", "R-HSA-9008059", "R-SCE-1632852", "R-MMU-912526", "R-HSA-5674404", "R-HSA-5654700", "R-HSA-909733", "R-GGA-912694", "R-HSA-1855204", "R-RNO-388844", "R-DME-416700", "R-MMU-1250196", "R-CEL-8948751", "R-MMU-72086", "R-MMU-5654712", "R-MMU-9696264", "R-MMU-354192", "R-RNO-5654712", "R-HSA-8865999", "R-HSA-9680350", "R-BTA-1660499", "R-HSA-1059683", "R-SCE-8948747", "R-RNO-1257604", "R-HSA-3785653", "R-HSA-8849932", "R-MMU-1483248", "R-RNO-5654727", "R-RNO-9860927", "R-HSA-388844", "R-DRE-176407", "R-RNO-912694", "R-RNO-354192", "R-HSA-877312", "R-DDI-8876198", "R-DDI-112409", "R-RNO-8856828", "R-GGA-936964", "R-GGA-1433557", "R-MMU-202670", "R-DDI-5689880", "R-MMU-936964", "R-HSA-9706369", "R-HSA-9696270", "R-DME-6798695", "R-HSA-5654726", "R-HSA-109704", "R-GGA-5654700", "R-MMU-1257604", "R-BTA-8849932", "R-HSA-6807004", "R-HSA-110056", "R-DDI-5675221", "R-RNO-5654689", "R-CEL-176407", "R-MMU-389513", "R-DME-9833482", "R-HSA-201556", "R-HSA-877300", "R-HSA-912526", "R-MMU-5654693", "R-MMU-6807004", "R-SCE-199418", "R-MMU-5654689", "R-DRE-1433557", "R-MMU-182971", "R-RNO-5654726", "R-DME-375165", "R-RNO-5654710", "R-GGA-5654727", "R-HSA-432142", "R-RNO-9927353", "R-MMU-1295596", "R-RNO-8849472", "R-CEL-9035034", "R-MMU-9833482", "R-HSA-3322077", "R-RNO-202424", "R-MMU-5654732", "R-DDI-1660517", "R-HSA-202430", "R-GGA-109704", "R-DME-112409", "R-GGA-180292", "R-GGA-8854691", "R-RNO-199418", "R-RNO-201556", "R-RNO-5654693", "R-CFA-1855204", "R-HSA-8849472", "R-RNO-8853659", "R-MMU-166016", "R-MMU-8849932", "R-GGA-8853659", "R-MMU-8853659", "R-MMU-982772", "R-HSA-5654732", "R-HSA-2219530", "R-MMU-5654700", "R-DME-202670", "R-HSA-8854691", "R-CEL-202424", "R-RNO-77387", "R-GGA-8934593", "R-HSA-982772", "R-DME-388844", "R-RNO-1660517", "R-RNO-389513", "R-HSA-9703648", "R-HSA-5654720", "R-HSA-8948751", "R-SPO-202670", "R-MMU-199418", "R-RNO-5689896", "R-HSA-9860927", "R-HSA-9674555", "R-HSA-5654733", "R-RNO-8849932", "R-GGA-5654710", "R-MMU-375165", "R-CEL-375165", "R-HSA-449836", "R-SPO-5687128", "R-HSA-8873719", "R-HSA-9034015", "R-RNO-8934593", "R-MMU-432722", "R-HSA-418886", "R-CEL-416700", "R-CEL-72086", "R-HSA-72086", "R-DME-9860927", "R-HSA-5628897", "R-SCE-8948751", "R-CEL-8876198", "R-GGA-6811558", "R-HSA-912694", "R-MMU-432720", "R-SCE-176407", "R-GGA-389513", "R-MMU-1855204", "R-HSA-9028731", "R-CFA-202424", "R-RNO-8948747", "R-HSA-354192", "R-DRE-5687128", "R-MMU-8854691", "R-RNO-112411", "R-HSA-8948747", "R-GGA-210990", "R-DME-77387", "R-BTA-112409", "R-MMU-983695", "R-RNO-180292", "R-HSA-1433557", "R-GGA-432142", "R-MMU-877300", "R-RNO-112409", "R-CFA-5689896", "R-HSA-9851151", "R-MMU-176407", "R-RNO-114604", "R-DME-8849932", "R-HSA-5687128", "R-RNO-8873719", "R-RNO-5654720", "R-CEL-1660499", "R-HSA-9022699", "R-MMU-8849472", "R-GGA-512988", "R-MMU-9696270", "R-GGA-437986", "R-RNO-186763", "R-HSA-9696273", "R-HSA-5675221"], "pathways": ["R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-389948:r:Co-inhibition by PD-1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-186797:r:Signaling by PDGF", "R-CEL-8948747:r:Regulation of PTEN localization", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1433559:r:Regulation of KIT signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-HSA-180292:r:GAB1 signalosome", "R-BTA-202670:r:ERKs are inactivated", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-6798695:r:Neutrophil degranulation", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-GGA-5654693:r:FRS-mediated FGFR1 signaling", "R-SCE-1483248:r:Synthesis of PIPs at the ER membrane", "R-DRE-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-SPO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-8865999:r:MET activates PTPN11", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-GGA-5654720:r:PI-3K cascade:FGFR4", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-1632852:r:Macroautophagy", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DRE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-416700:r:Other semaphorin interactions", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-SPO-1632852:r:Macroautophagy", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-432142:r:Platelet sensitization by LDL", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CFA-8948751:r:Regulation of PTEN stability and activity", "R-DDI-8948747:r:Regulation of PTEN localization", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-109704:r:PI3K Cascade", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1483148:r:Synthesis of PG", "R-CFA-5689880:r:Ub-specific processing proteases", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-186763:r:Downstream signal transduction", "R-HSA-210990:r:PECAM1 interactions", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-389948:r:Co-inhibition by PD-1", "R-BTA-1483248:r:Synthesis of PIPs at the ER membrane", "R-CFA-8948747:r:Regulation of PTEN localization", "R-HSA-9645135:r:STAT5 Activation", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DRE-72086:r:mRNA Capping", "R-RNO-982772:r:Growth hormone receptor signaling", "R-DME-877312:r:Regulation of IFNG signaling", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-202670:r:ERKs are inactivated", "R-HSA-186763:r:Downstream signal transduction", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-9652817:r:Signaling by MAPK mutants", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-SCE-202424:r:Downstream TCR signaling", "R-RNO-449836:r:Other interleukin signaling", "R-DDI-5689896:r:Ovarian tumor domain proteases", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-3000178:r:ECM proteoglycans", "R-GGA-8865999:r:MET activates PTPN11", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-210993:r:Tie2 Signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-GGA-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-1632852:r:Macroautophagy", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210990:r:PECAM1 interactions", "R-CFA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-8853659:r:RET signaling", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-CEL-112409:r:RAF-independent MAPK1/3 activation", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-BTA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-GGA-5654689:r:PI-3K cascade:FGFR1", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-SCE-202670:r:ERKs are inactivated", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9696264:r:RND3 GTPase cycle", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-112409:r:RAF-independent MAPK1/3 activation", "R-GGA-389948:r:Co-inhibition by PD-1", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-77387:r:Insulin receptor recycling", "R-CEL-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-DDI-1632852:r:Macroautophagy", "R-MMU-109704:r:PI3K Cascade", "R-GGA-210993:r:Tie2 Signaling", "R-RNO-416700:r:Other semaphorin interactions", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-DME-8873719:r:RAB geranylgeranylation", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-HSA-9636569:r:Suppression of autophagy", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8873719:r:RAB geranylgeranylation", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-6807004:r:Negative regulation of MET activity", "R-GGA-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DDI-8873719:r:RAB geranylgeranylation", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-77387:r:Insulin receptor recycling", "R-MMU-1632852:r:Macroautophagy", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-GGA-5654695:r:PI-3K cascade:FGFR2", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-CEL-202670:r:ERKs are inactivated", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-DDI-202424:r:Downstream TCR signaling", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-201556:r:Signaling by ALK", "R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-112409:r:RAF-independent MAPK1/3 activation", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", 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signaling", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-RNO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-9948011:r:CASP5 inflammasome assembly", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-111458:r:Formation of apoptosome", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-RNO-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-69416:r:Dimerization of procaspase-8", "R-MMU-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-DME-9948001:r:CASP4 inflammasome assembly", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-69416:r:Dimerization of procaspase-8", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-DRE-9948001:r:CASP4 inflammasome assembly", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-5620971:r:Pyroptosis", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-9960519:r:CASP4-mediated substrate cleavage", "R-DME-2028269:r:Signaling by Hippo", "R-RNO-75153:r:Apoptotic execution phase", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-RNO-5620971:r:Pyroptosis", "R-DME-111458:r:Formation of apoptosome", "R-DME-69416:r:Dimerization of procaspase-8", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-RNO-3371378:r:Regulation by c-FLIP", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-202424:r:Downstream TCR signaling", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-5218900:r:CASP8 activity is inhibited", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-5660668:r:CLEC7A/inflammasome pathway", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-75153:r:Apoptotic execution phase", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-69416:r:Dimerization of procaspase-8", "R-MMU-9948001:r:CASP4 inflammasome assembly", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9948011:r:CASP5 inflammasome assembly", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-205025:r:NADE modulates death signalling", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-844615:r:The AIM2 inflammasome", "R-BTA-9948011:r:CASP5 inflammasome assembly", "R-DRE-9960525:r:CASP5-mediated substrate cleavage", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-BTA-9960525:r:CASP5-mediated substrate cleavage", "R-RNO-75158:r:TRAIL signaling", "R-CEL-9948011:r:CASP5 inflammasome assembly", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DME-352238:r:Breakdown of the nuclear lamina", "R-RNO-448706:r:Interleukin-1 processing", "R-HSA-75108:r:Activation, myristolyation of BID and translocation to mitochondria", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-BTA-9960519:r:CASP4-mediated substrate cleavage", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-5620971:r:Pyroptosis", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DRE-9948011:r:CASP5 inflammasome assembly", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-75158:r:TRAIL signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-DME-3371378:r:Regulation by c-FLIP", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-3371378:r:Regulation by c-FLIP", "R-MMU-75158:r:TRAIL signaling", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-RNO-352238:r:Breakdown of the nuclear lamina", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-RNO-75157:r:FasL/ CD95L signaling", "R-DME-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-75157:r:FasL/ CD95L signaling", "R-MMU-205025:r:NADE modulates death signalling", "R-HSA-211736:r:Stimulation of the cell death response by PAK-2p34", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-448706:r:Interleukin-1 processing", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-HSA-352238:r:Breakdown of the nuclear lamina", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-75153:r:Apoptotic execution phase", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-MMU-2028269:r:Signaling by Hippo", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-352238:r:Breakdown of the nuclear lamina", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-RNO-5218900:r:CASP8 activity is inhibited", "R-HSA-75157:r:FasL/ CD95L signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DME-75153:r:Apoptotic execution phase", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-5620971:r:Pyroptosis", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Homologous_superfamily"}, "IPR029031": {"description": "Gingipain, N-terminal superfamily", "go_ids": [], "go_terms": [], "name": "Gingipain_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR029032": {"description": "AhpD-like", "go_ids": [], "go_terms": [], "name": "AhpD-like", "pathway_ids": ["R-DDI-9639288", "R-DDI-5628897", "R-DDI-9755511", "R-CEL-9755511", "R-BTA-9755511", "R-CEL-5628897", "R-MMU-9639288", "R-HSA-9755511", "R-MMU-9755511", "R-HSA-9639288", "R-HSA-5628897", "R-BTA-5628897", "R-DME-9755511", "R-HSA-1222541", "R-MMU-5628897", "R-DME-5628897", "R-BTA-9639288"], "pathways": ["R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1222541:r:Cell redox homeostasis", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR029033": {"description": "Histidine phosphatase superfamily", "go_ids": [], "go_terms": [], "name": "His_PPase_superfam", "pathway_ids": ["R-HSA-6798695", "R-RNO-9861718", "R-MMU-70171", "R-SPO-6798695", "R-MMU-8934903", "R-HSA-1855167", "R-RNO-8934903", "R-SPO-9634600", "R-CEL-6798695", "R-MMU-9861718", "R-SCE-6798695", "R-BTA-6798695", "R-MMU-70263", "R-HSA-1483166", "R-HSA-5628897", "R-DDI-70263", "R-RNO-1855167", "R-HSA-9861718", "R-RNO-70171", "R-GGA-352882", "R-HSA-70263", "R-MMU-9634600", "R-SPO-1483166", "R-SPO-1855167", "R-XTR-5628897", "R-BTA-1855167", "R-MMU-5628897", "R-BTA-1483166", "R-CEL-1855167", "R-DME-1855167", "R-SCE-9634600", "R-HSA-1855231", "R-SCE-1855167", "R-HSA-70171", "R-HSA-163358", "R-BTA-9634600", "R-DDI-6798695", "R-DRE-9861718", "R-HSA-8934903", "R-HSA-163767", "R-DME-1855231", "R-DRE-8934903", "R-MMU-1855167", "R-SCE-70171", "R-CEL-8934903", "R-RNO-1855231", "R-BTA-70171", "R-HSA-1971475", "R-DME-8934903", "R-DDI-70171", "R-GGA-352875", "R-DME-9861718", "R-BTA-5628897", "R-HSA-9634600", "R-MMU-1483166", "R-CEL-9861718", "R-RNO-1971475", "R-BTA-70263", "R-RNO-9634600", "R-DDI-1483166", "R-SCE-70263", "R-MMU-6798695", "R-CEL-9634600", "R-MMU-1855231", "R-MMU-1971475", "R-DDI-1855231", "R-RNO-6798695", "R-DRE-1971475", "R-DRE-5628897", "R-RNO-70263"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-MMU-70171:r:Glycolysis", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-HSA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-SPO-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-70263:r:Gluconeogenesis", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-MMU-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-SPO-1483166:r:Synthesis of PA", "R-SPO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-XTR-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-1483166:r:Synthesis of PA", "R-CEL-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-DME-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-SCE-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-HSA-1855231:r:Synthesis of IPs in the ER lumen", "R-SCE-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-70171:r:Glycolysis", "R-HSA-163358:r:PKA-mediated phosphorylation of key metabolic factors", "R-BTA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-DME-1855231:r:Synthesis of IPs in the ER lumen", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-MMU-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-SCE-70171:r:Glycolysis", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-RNO-1855231:r:Synthesis of IPs in the ER lumen", "R-BTA-70171:r:Glycolysis", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DME-8934903:r:Receptor Mediated Mitophagy", "R-DDI-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", 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"R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-205025:r:NADE modulates death signalling", "R-HSA-418555:r:G alpha (s) signalling events", "R-BTA-1502540:r:Signaling by Activin", "R-HSA-419037:r:NCAM1 interactions", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-193048:r:Androgen biosynthesis", "R-SSC-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-MMU-170984:r:ARMS-mediated activation", "R-MMU-209968:r:Thyroxine biosynthesis", "R-HSA-168277:r:Influenza Virus Induced Apoptosis", "R-DRE-198203:r:PI3K/AKT activation", "R-HSA-194138:r:Signaling by VEGF", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DRE-114608:r:Platelet degranulation", "R-RNO-1257604:r:PIP3 activates AKT signaling", 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"R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-DRE-187042:r:TRKA activation by NGF", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-209968:r:Thyroxine biosynthesis", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-XTR-201451:r:Signaling by BMP", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-BTA-209968:r:Thyroxine biosynthesis", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-MMU-375281:r:Hormone ligand-binding receptors", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-SSC-209822:r:Glycoprotein hormones", "R-DME-3000170:r:Syndecan interactions", 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"R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-203754:r:NOSIP mediated eNOS trafficking", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-SPO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-5578775:r:Ion homeostasis", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-156581:r:Methylation", "R-HSA-211897:r:Cytochrome P450 - arranged by substrate type", "R-SCE-5578775:r:Ion homeostasis", "R-DDI-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular 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in phagocytes", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-SPO-5578775:r:Ion homeostasis", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-DME-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-5578775:r:Ion homeostasis", "R-DME-5578775:r:Ion homeostasis", "R-DME-9033241:r:Peroxisomal protein import", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9033241:r:Peroxisomal protein import", "R-DME-203615:r:eNOS activation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-SPO-203615:r:eNOS 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"R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-HSA-73780", "R-DDI-76042", "R-MMU-73776", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-HSA-76071", "R-DME-113418", "R-HSA-72203", "R-MMU-6796648", "R-CEL-75955", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-SCE-6781823", "R-MMU-76071", "R-BTA-674695", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-73863", "R-HSA-167290", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-HSA-674695", "R-HSA-76042", "R-BTA-6807505", "R-BTA-72203", "R-SCE-73772", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-BTA-76042", "R-SPO-6807505", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-DRE-6807505", "R-HSA-167287", "R-BTA-76061", "R-HSA-167246", "R-DRE-6796648", "R-DRE-113418", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-SPO-73762", "R-SPO-75953", "R-HSA-5601884", "R-SPO-113418", "R-MMU-5250924", "R-DDI-73779", "R-DME-674695", "R-BTA-72086", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-CEL-113418", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-MMU-9018519", "R-SPO-9770562", "R-HSA-167200", "R-SCE-73762", "R-SCE-674695", "R-BTA-9770562", "R-MMU-6782210", "R-CEL-6796648", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-SCE-76066", "R-MMU-73762", "R-MMU-6782135", "R-HSA-76066", "R-BTA-113418", "R-DME-6796648", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-DDI-76061", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-BTA-112382", "R-SCE-6782210", "R-HSA-9918481", "R-BTA-6796648", "R-SCE-72203", "R-SCE-6796648", "R-SPO-72203", "R-BTA-73762", "R-SPO-77075", "R-SCE-113418", "R-SCE-72086", "R-MMU-73863", "R-HSA-6782135", "R-HSA-73762", "R-DRE-674695", "R-SCE-77075", "R-HSA-5250924", "R-DDI-75953", "R-SPO-6782135"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA 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"R-HSA-4717374:r:Defective DPM1 causes DPM1-CDG", "R-MMU-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-CEL-975577:r:N-Glycan antennae elongation", "R-DRE-975577:r:N-Glycan antennae elongation", "R-DME-446205:r:Synthesis of GDP-mannose", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DRE-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DME-975577:r:N-Glycan antennae elongation", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-9033807:r:ABO blood group biosynthesis", "R-HSA-2142845:r:Hyaluronan metabolism", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-3322077:r:Glycogen synthesis", "R-SPO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-4719360:r:Defective DPM3 causes DPM3-CDG", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-HSA-3828062:r:Glycogen storage disease type 0 (muscle GYS1)", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-HSA-4085001:r:Sialic acid metabolism", "R-SSC-913709:r:O-linked glycosylation of mucins", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-XTR-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-975577:r:N-Glycan antennae elongation", "R-XTR-446205:r:Synthesis of GDP-mannose", "R-SCE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-2142845:r:Hyaluronan metabolism", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-MMU-162699:r:Synthesis of dolichyl-phosphate mannose", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5083627:r:Defective LARGE causes MDDGA6 and MDDGB6", "R-HSA-3878781:r:Glycogen storage disease type IV (GBE1)", "R-RNO-4085001:r:Sialic acid metabolism", "R-BTA-5653890:r:Lactose synthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9683673:r:Maturation of protein 3a", "R-HSA-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-HSA-5083628:r:Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "R-DME-913709:r:O-linked glycosylation of mucins", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-4793953:r:Defective B4GALT1 causes CDG-2d", "R-SCE-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-HSA-9694719:r:Maturation of protein 3a", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-3322077:r:Glycogen synthesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-446205:r:Synthesis of GDP-mannose", "R-SPO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-BTA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-MMU-5653890:r:Lactose synthesis", "R-RNO-446205:r:Synthesis of GDP-mannose", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-CFA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DDI-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-DDI-446205:r:Synthesis of GDP-mannose", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-BTA-4085001:r:Sialic acid metabolism", "R-DME-9840309:r:Glycosphingolipid biosynthesis", "R-DME-480985:r:Synthesis of dolichyl-phosphate-glucose", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DDI-3322077:r:Glycogen synthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-DME-2022928:r:HS-GAG biosynthesis", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-DRE-2022928:r:HS-GAG biosynthesis", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-975577:r:N-Glycan antennae elongation", "R-HSA-9931953:r:Biofilm formation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-XTR-913709:r:O-linked glycosylation of mucins", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-9037629:r:Lewis blood group biosynthesis", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-4793952:r:Defective MGAT2 causes CDG-2a"], "type": "Homologous_superfamily"}, "IPR029045": {"description": "ClpP/crotonase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "ClpP/crotonase-like_dom_sf", "pathway_ids": ["R-RNO-1482798", "R-DDI-75105", "R-CEL-77348", "R-DRE-390247", "R-HSA-77346", "R-MMU-77352", "R-SSC-77346", "R-RNO-77305", "R-RNO-9033241", "R-MMU-77346", "R-RNO-77285", "R-SPO-70895", "R-SPO-200425", "R-BTA-9837999", "R-HSA-71032", "R-SCE-9033241", "R-BTA-77352", "R-MMU-1482798", "R-HSA-2187335", "R-SSC-77305", "R-DRE-70895", "R-HSA-77352", "R-DDI-9033241", "R-SCE-200425", "R-CEL-77346", "R-BTA-70895", "R-HSA-9914274", "R-CEL-9837999", "R-MMU-200425", "R-HSA-9916722", "R-MMU-77350", "R-MMU-2453902", "R-SCE-390247", "R-SSC-1482798", "R-HSA-70895", "R-HSA-77348", "R-CEL-77310", "R-DDI-77350", "R-DDI-77346", "R-DDI-77348", "R-MMU-196780", "R-MMU-77348", "R-DME-70895", "R-BTA-77350", "R-HSA-77310", "R-BTA-77346", "R-SSC-77285", "R-HSA-390247", "R-HSA-75105", "R-MMU-390247", "R-HSA-9909438", "R-MMU-2187335", "R-SCE-196780", "R-MMU-77288", "R-SCE-75105", "R-RNO-77352", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-CEL-77350", "R-DDI-70895", "R-HSA-196780", "R-RNO-77310", "R-RNO-75105", "R-HSA-77350", "R-DDI-200425", "R-HSA-77285", "R-SCE-70895", "R-SSC-77310", "R-RNO-196780", "R-RNO-77350", "R-DDI-196780", "R-RNO-77288", "R-MMU-70895", "R-RNO-200425", "R-CEL-70895", "R-MMU-77310", "R-RNO-77348", "R-RNO-71032", "R-HSA-9837999", "R-HSA-77305", "R-MMU-71032", "R-HSA-2426168", "R-HSA-163765", "R-CEL-196780", "R-SSC-77348", "R-DDI-9837999", "R-DME-196780", "R-HSA-9916720", "R-SSC-77350", "R-SPO-75105", "R-CEL-77352", "R-BTA-77310", "R-MMU-9033241", "R-RNO-9837999", "R-DDI-77310", "R-HSA-3371599", "R-MMU-75105", "R-HSA-1482798", "R-MMU-77285", "R-BTA-77348", "R-RNO-70895", "R-SPO-196780", "R-MMU-77305", "R-HSA-200425", "R-DDI-77352", "R-HSA-9033241", "R-RNO-390247", "R-HSA-2453902"], "pathways": ["R-RNO-1482798:r:Acyl chain remodeling of CL", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-DRE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SSC-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-SPO-70895:r:Branched-chain amino acid catabolism", "R-SPO-200425:r:Carnitine shuttle", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-SCE-9033241:r:Peroxisomal protein import", "R-BTA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-HSA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-SSC-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-DRE-70895:r:Branched-chain amino acid catabolism", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-DDI-9033241:r:Peroxisomal protein import", "R-SCE-200425:r:Carnitine shuttle", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9914274:r:3-methylglutaconic aciduria", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-MMU-200425:r:Carnitine shuttle", "R-HSA-9916722:r:3-hydroxyisobutyryl-CoA hydrolase deficiency", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-SSC-1482798:r:Acyl chain remodeling of CL", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-CEL-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-DDI-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DDI-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-196780:r:Biotin transport and metabolism", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-DME-70895:r:Branched-chain amino acid catabolism", "R-BTA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9909438:r:3-Methylcrotonyl-CoA carboxylase deficiency", "R-MMU-2187335:r:The retinoid cycle in cones (daylight vision)", "R-SCE-196780:r:Biotin transport and metabolism", "R-MMU-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-CEL-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-196780:r:Biotin transport and metabolism", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DDI-200425:r:Carnitine shuttle", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-SCE-70895:r:Branched-chain amino acid catabolism", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-196780:r:Biotin transport and metabolism", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DDI-196780:r:Biotin transport and metabolism", "R-RNO-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-RNO-200425:r:Carnitine shuttle", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-71032:r:Propionyl-CoA catabolism", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-CEL-196780:r:Biotin transport and metabolism", "R-SSC-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DME-196780:r:Biotin transport and metabolism", "R-HSA-9916720:r:Mitochondrial short-chain enoyl-CoA hydratase deficiency 1", "R-SSC-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-BTA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DDI-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-200425:r:Carnitine shuttle", "R-DDI-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Homologous_superfamily"}, "IPR029046": {"description": "Lipoprotein localisation LolA/LolB/LppX", "go_ids": [], "go_terms": [], "name": "LolA/LolB/LppX", "pathway_ids": ["R-HSA-9636383"], "pathways": ["R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion"], "type": "Homologous_superfamily"}, "IPR029047": {"description": "Heat shock protein 70kD, peptide-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "HSP70_peptide-bd_sf", "pathway_ids": ["R-SCE-3371453", "R-MMU-450408", "R-MMU-8856828", "R-SSC-3371497", "R-HSA-9833482", "R-HSA-6799198", "R-RNO-6799198", "R-HSA-381042", "R-HSA-9918485", "R-HSA-9918487", "R-SCE-9841251", "R-RNO-72163", "R-DRE-3371497", "R-DDI-72163", "R-SSC-9833482", "R-CFA-3371497", "R-DDI-9865881", "R-RNO-3371571", "R-BTA-9865881", "R-HSA-450408", "R-SSC-3371568", "R-RNO-450408", "R-BTA-72163", "R-DDI-6798695", "R-HSA-381183", "R-MMU-72163", "R-HSA-432720", "R-DRE-3371453", "R-DDI-8876725", "R-HSA-447041", "R-HSA-72163", "R-MMU-3371568", "R-MMU-9841251", "R-SPO-9841251", "R-MMU-983170", "R-DRE-3371571", "R-CFA-9841251", "R-BTA-9833482", "R-RNO-6798695", "R-MMU-3371497", "R-SCE-3371497", "R-SCE-8876725", "R-SPO-3371453", "R-SSC-6798695", "R-MMU-9837999", "R-SSC-450408", "R-DME-6799198", "R-SCE-6798695", "R-CEL-3371571", "R-RNO-3371497", "R-HSA-3371497", "R-SCE-3371568", "R-MMU-9865881", "R-DRE-72163", "R-HSA-114608", "R-RNO-8856828", "R-HSA-9837999", "R-HSA-9615710", "R-GGA-983170", "R-HSA-3371568", "R-SSC-3371453", "R-MMU-3371453", "R-BTA-8856828", "R-DDI-9837999", "R-HSA-381038", "R-SPO-3371568", "R-HSA-9828642", "R-DDI-3371453", "R-DME-6798695", "R-HSA-9841251", "R-MMU-3371571", "R-CFA-3371568", "R-HSA-168330", "R-HSA-983170", "R-HSA-381070", "R-CFA-3371453", "R-DDI-3371497", "R-HSA-8874177", "R-SCE-9837999", "R-HSA-3371571", "R-CFA-6798695", "R-SPO-72163", "R-RNO-9833482", "R-CEL-3371453", "R-HSA-6798695", "R-BTA-9909505", "R-DRE-3371568", "R-HSA-3000484", "R-BTA-3371568", "R-HSA-8856828", "R-SPO-3371571", "R-CEL-6798695", "R-DME-3371497", "R-BTA-6798695", "R-MMU-9833482", "R-HSA-3371453", "R-DME-3371571", "R-DRE-6798695", "R-HSA-1268020", "R-DDI-9841251", "R-HSA-6803157", "R-BTA-9837999", "R-CFA-9833482", "R-HSA-9613354", "R-SSC-3371571", "R-BTA-6799198", "R-BTA-8876725", "R-RNO-432722", "R-HSA-9865881", "R-DME-3371453", "R-CEL-9837999", "R-BTA-3371453", "R-BTA-450408", "R-MMU-6799198", "R-HSA-9918432", "R-RNO-432720", "R-GGA-9909505", "R-BTA-3371571", "R-HSA-8950505", "R-BTA-888590", "R-SCE-9865881", "R-HSA-6785807", "R-DDI-6799198", "R-HSA-8949613", "R-HSA-381033", "R-SSC-9841251", "R-DME-9841251", "R-HSA-9613829", 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and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-5693548:r:Sensing of DNA Double Strand Breaks", "R-SSC-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SCE-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-XTR-68877:r:Mitotic Prometaphase", "R-HSA-163560:r:Triglyceride catabolism", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-389356:r:Co-stimulation by CD28", "R-RNO-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-74259:r:Purine catabolism", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-198753:r:ERK/MAPK targets", "R-CFA-180024:r:DARPP-32 events", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Homologous_superfamily"}, "IPR029053": {"description": "Viral coat protein subunit", "go_ids": [], "go_terms": [], "name": "Viral_coat", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR029054": {"description": "dUTPase-like", "go_ids": [], "go_terms": [], "name": "dUTPase-like", "pathway_ids": ["R-SCE-499943", "R-SPO-499943", "R-HSA-499943", "R-DDI-499943", "R-RNO-499943", "R-MMU-499943"], "pathways": ["R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Domain"}, "IPR029055": {"description": "Nucleophile aminohydrolases, N-terminal", "go_ids": [], "go_terms": [], "name": "Ntn_hydrolases_N", "pathway_ids": ["R-DRE-5358346", 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"R-DRE-8951664", "R-BTA-5668541", "R-MMU-73817", "R-HSA-5676590", "R-DRE-9954709", "R-DDI-5632684", "R-CEL-9912633", "R-HSA-4641257", "R-RNO-202424", "R-HSA-174113", "R-BTA-9762114", "R-RNO-5607761", "R-CEL-4641258", "R-HSA-9755511", "R-RNO-9931269", "R-SSC-69601", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-HSA-187577", "R-DRE-9912633", "R-DDI-9755511", "R-DME-382556", "R-DME-5610780", "R-SSC-174178", "R-SSC-8951664", "R-SPO-1236974", "R-DME-195253", "R-MMU-69601", "R-SSC-174084", "R-CEL-1236974", "R-SCE-5423646", "R-DRE-8852276", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-SPO-9753281", "R-SSC-5658442", "R-HSA-5607764", "R-DRE-5687128", "R-CEL-1236978", "R-RNO-4608870", "R-SSC-9954709", "R-SSC-8852276", "R-SCE-174403", "R-DME-538864", "R-MMU-8964208", "R-SCE-9907900", "R-HSA-5668541", "R-CEL-68949", "R-DME-5632684", "R-HSA-5687128", "R-RNO-8964208", "R-DME-432395", 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"R-HSA-500753:r:Pyrimidine biosynthesis", "R-HSA-73614:r:Pyrimidine salvage", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-74217:r:Purine salvage", "R-DDI-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-HSA-9734195:r:Defective APRT disrupts adenine salvage", "R-MMU-73614:r:Pyrimidine salvage", "R-SPO-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-CEL-74217:r:Purine salvage", "R-GGA-419140:r:De novo synthesis of IMP", "R-SSC-74217:r:Purine salvage", "R-DME-74217:r:Purine salvage", "R-HSA-9748787:r:Azathioprine ADME", "R-DDI-74217:r:Purine salvage", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-9748787:r:Azathioprine ADME", "R-HSA-74217:r:Purine salvage", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-9748787:r:Azathioprine ADME", "R-SCE-73614:r:Pyrimidine salvage", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-74217:r:Purine salvage", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-73614:r:Pyrimidine salvage"], "type": "Homologous_superfamily"}, "IPR029058": {"description": "Alpha/Beta hydrolase fold", "go_ids": [], "go_terms": [], "name": "AB_hydrolase_fold", "pathway_ids": ["R-HSA-71240", "R-XTR-426048", "R-BTA-1483115", "R-DRE-9648002", "R-HSA-8963889", "R-CEL-211945", "R-MMU-381771", "R-CEL-75105", "R-HSA-140837", "R-XTR-9648002", "R-MMU-1483191", "R-SCE-204005", "R-HSA-9918487", "R-SPO-1482839", "R-HSA-8963901", "R-RNO-1482883", "R-SCE-8964058", "R-CEL-2132295", "R-MMU-199220", "R-DDI-1482883", "R-HSA-203615", "R-RNO-162791", "R-MMU-975634", "R-MMU-422085", "R-RNO-9033241", "R-RNO-72764", "R-HSA-192456", "R-SPO-9648002", "R-RNO-77289", "R-DME-75105", "R-DDI-112311", "R-DDI-8964038", "R-DME-8964038", "R-CEL-381771", "R-MMU-8964058", "R-RNO-156584", "R-SCE-381771", "R-HSA-77289", "R-MMU-5578768", "R-MMU-426048", "R-MMU-192456", "R-DME-6809371", "R-BTA-975634", "R-HSA-2022377", "R-MMU-1482839", "R-HSA-422085", "R-MMU-8963901", "R-RNO-203615", "R-RNO-9018682", "R-CEL-9648002", 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"R-RNO-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-DRE-1482801:r:Acyl chain remodelling of PS", "R-SPO-196757:r:Metabolism of folate and pterines", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9018682:r:Biosynthesis of maresins", "R-SPO-1483226:r:Synthesis of PI", "R-HSA-9696273:r:RND1 GTPase cycle", "R-SCE-426048:r:Arachidonate production from DAG"], "type": "Homologous_superfamily"}, "IPR029059": {"description": "Alpha/beta hydrolase fold-5", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "AB_hydrolase_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029060": {"description": "PIN-like domain superfamily", "go_ids": [], "go_terms": [], "name": "PIN-like_dom_sf", "pathway_ids": ["R-HSA-1989781", "R-RNO-174437", "R-HSA-5693616", "R-HSA-5693579", "R-GGA-174437", "R-GGA-110362", "R-RNO-5685939", "R-MMU-6804756", "R-BTA-5685939", "R-RNO-110362", "R-CEL-69166", "R-SPO-9930044", "R-MMU-5693616", "R-DRE-110362", "R-MMU-5685938", "R-SCE-450385", "R-MMU-69473", "R-SPO-5696395", "R-MMU-5696395", "R-SCE-429958", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-380994", "R-SCE-6791226", "R-CEL-5685939", "R-MMU-174437", "R-MMU-5693568", "R-HSA-429958", "R-SPO-5685939", "R-PFA-69166", "R-SPO-69166", "R-MMU-5358565", "R-MMU-9930044", "R-MMU-6791226", "R-DME-5651801", "R-BTA-6791226", "R-SPO-5358565", "R-MMU-5651801", "R-HSA-69473", "R-HSA-110362", "R-GGA-5685939", "R-XTR-110362", "R-HSA-6804756", "R-GGA-5651801", "R-DRE-5358565", "R-SCE-69166", "R-HSA-5696395", "R-MMU-450604", "R-HSA-9704331", "R-HSA-6791226", "R-HSA-450604", "R-CEL-5651801", "R-HSA-5693554", "R-SCE-6782135", "R-SPO-5651801", "R-MMU-450385", "R-HSA-9930044", "R-HSA-5685942", "R-MMU-6782135", "R-DDI-6791226", "R-MMU-429958", "R-HSA-9704646", "R-HSA-5358606", "R-BTA-174437", "R-DRE-5685939", "R-DME-5358565", "R-HSA-6790901", "R-DRE-69166", 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Patch Base Excision Repair", "R-XTR-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DDI-69166:r:Removal of the Flap Intermediate", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", 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"go_terms": [], "name": "THDP-binding", "pathway_ids": ["R-HSA-71336", "R-HSA-389599", "R-HSA-9853506", "R-BTA-5362517", "R-SCE-389599", "R-DME-9861559", "R-MMU-163754", "R-MMU-389599", "R-DDI-9858328", "R-RNO-9033241", "R-MMU-9861559", "R-CFA-9861559", "R-BTA-204174", "R-BTA-6783984", "R-BTA-9859138", "R-BTA-9837999", "R-SCE-9033241", "R-CEL-9861559", "R-HSA-9912481", "R-CEL-9859138", "R-DRE-9858328", "R-DDI-9033241", "R-CFA-9837999", "R-RNO-163754", "R-DME-204174", "R-BTA-70895", "R-CEL-9837999", "R-DDI-389599", "R-CEL-6783984", "R-CEL-5362517", "R-CEL-9853506", "R-HSA-70895", "R-HSA-9907570", "R-CFA-204174", "R-RNO-71336", "R-RNO-9858328", "R-HSA-9861559", "R-RNO-9853506", "R-SSC-9853506", "R-MMU-204174", "R-SSC-6783984", "R-CEL-9858328", "R-MMU-9859138", "R-RNO-389599", "R-MMU-9858328", "R-HSA-9912529", "R-HSA-163754", "R-RNO-5362517", "R-MMU-71336", "R-DDI-9859138", "R-MMU-9837999", "R-SSC-9861559", "R-SPO-9861559", "R-SPO-9853506", "R-SSC-204174", "R-HSA-9858328", "R-MMU-70895", "R-DDI-6783984", "R-HSA-9837999", "R-SPO-6783984", "R-MMU-9853506", "R-HSA-5362517", "R-HSA-9818028", "R-CFA-5362517", "R-HSA-9859138", "R-RNO-9861559", "R-SSC-5362517", "R-BTA-9853506", "R-DDI-9837999", "R-DME-9858328", "R-HSA-204174", "R-SPO-5362517", "R-SCE-9853506", "R-MMU-6783984", "R-RNO-204174", "R-BTA-9861559", "R-HSA-9865125", "R-CEL-204174", "R-SCE-6783984", "R-DME-9837999", "R-MMU-9033241", "R-RNO-9837999", "R-RNO-70895", "R-RNO-6783984", "R-DDI-9853506", "R-SPO-389599", "R-SPO-9033241", "R-RNO-9859138", "R-SCE-9861559", "R-SPO-9837999", "R-SCE-9837999", "R-MMU-5362517", "R-HSA-6783984", "R-SSC-9837999", "R-HSA-9865113", "R-DDI-9861559", "R-HSA-9033241", "R-DME-5362517", "R-SPO-204174"], "pathways": ["R-HSA-71336:r:Pentose phosphate pathway", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-BTA-5362517:r:Signaling by Retinoic Acid", "R-SCE-389599:r:Alpha-oxidation of phytanate", "R-DME-9861559:r:PDH complex 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"R-CFA-9837999:r:Mitochondrial protein degradation", "R-RNO-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-DME-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DDI-389599:r:Alpha-oxidation of phytanate", "R-CEL-6783984:r:Glycine degradation", "R-CEL-5362517:r:Signaling by Retinoic Acid", "R-CEL-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9907570:r:Loss-of-function mutations in DLD cause MSUD3/DLDD", "R-CFA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-71336:r:Pentose phosphate pathway", "R-RNO-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SSC-6783984:r:Glycine degradation", "R-CEL-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-MMU-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-HSA-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-RNO-5362517:r:Signaling by Retinoic Acid", "R-MMU-71336:r:Pentose phosphate pathway", "R-DDI-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SSC-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SPO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-DDI-6783984:r:Glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-CFA-5362517:r:Signaling by Retinoic Acid", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-RNO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SSC-5362517:r:Signaling by Retinoic Acid", "R-BTA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DME-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-6783984:r:Glycine degradation", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-BTA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-9865125:r:Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD", "R-CEL-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SCE-6783984:r:Glycine degradation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-RNO-6783984:r:Glycine degradation", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SPO-389599:r:Alpha-oxidation of phytanate", "R-SPO-9033241:r:Peroxisomal protein import", "R-RNO-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-SCE-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-6783984:r:Glycine degradation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-DDI-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-5362517:r:Signaling by Retinoic Acid", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex"], "type": "Homologous_superfamily"}, "IPR029062": {"description": "Class I glutamine amidotransferase-like", "go_ids": [], "go_terms": [], "name": "Class_I_gatase-like", "pathway_ids": ["R-MMU-500753", "R-SPO-73817", "R-HSA-6798695", "R-SPO-6798695", "R-HSA-9646399", "R-DDI-9748787", "R-SCE-500753", "R-GGA-499943", "R-SCE-73817", "R-BTA-6798695", "R-CEL-73817", "R-DDI-500753", "R-MMU-73817", "R-BTA-3899300", "R-CEL-3899300", "R-HSA-9955542", "R-HSA-499943", "R-MMU-499943", "R-CEL-9646399", "R-DDI-73817", "R-CEL-9748787", "R-DME-499943", "R-DME-500753", "R-CEL-500753", "R-RNO-73817", "R-HSA-9615710", "R-SPO-3899300", "R-RNO-9748787", "R-RNO-3899300", "R-DDI-499943", "R-MMU-9748787", "R-DDI-6798695", "R-SCE-9748787", "R-DRE-9646399", "R-HSA-500753", "R-MMU-3899300", "R-SPO-500753", "R-DME-9646399", "R-HSA-70635", "R-SCE-499943", "R-SPO-499943", "R-PFA-73817", "R-RNO-70635", "R-MMU-70635", "R-SPO-196780", "R-MMU-9646399", "R-DRE-499943", "R-HSA-9748787", "R-DME-73817", "R-BTA-499943", "R-RNO-9646399", "R-HSA-9613829", "R-SPO-9748787", "R-SCE-196780", "R-BTA-9646399", "R-HSA-73817", "R-HSA-3899300", "R-MMU-6798695", "R-PFA-9748787", "R-RNO-6798695", "R-RNO-499943"], "pathways": ["R-MMU-500753:r:Pyrimidine biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DDI-9748787:r:Azathioprine ADME", "R-SCE-500753:r:Pyrimidine biosynthesis", "R-GGA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-3899300:r:SUMOylation of transcription cofactors", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9955542:r:CPS1 variants cause CPS1 deficiency", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-9646399:r:Aggrephagy", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-9748787:r:Azathioprine ADME", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-500753:r:Pyrimidine biosynthesis", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-RNO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-9615710:r:Late endosomal microautophagy", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9748787:r:Azathioprine ADME", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-9748787:r:Azathioprine ADME", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-9748787:r:Azathioprine ADME", "R-DRE-9646399:r:Aggrephagy", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-SPO-500753:r:Pyrimidine biosynthesis", "R-DME-9646399:r:Aggrephagy", "R-HSA-70635:r:Urea cycle", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-RNO-70635:r:Urea cycle", "R-MMU-70635:r:Urea cycle", "R-SPO-196780:r:Biotin transport and metabolism", "R-MMU-9646399:r:Aggrephagy", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", 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"IPR029066": {"description": "PLP-binding barrel", "go_ids": [], "go_terms": [], "name": "PLP-binding_barrel", "pathway_ids": ["R-CEL-351143", "R-HSA-351143", "R-SPO-351143", "R-SPO-351202", "R-DME-351143", "R-CEL-351202", "R-SPO-350562", "R-MMU-350562", "R-RNO-351143", "R-BTA-350562", "R-DME-350562", "R-HSA-351202", "R-DME-351202", "R-RNO-351202", "R-RNO-350562", "R-DDI-351202", "R-MMU-351143", "R-SCE-351143", "R-DDI-351143", "R-MMU-351202", "R-SCE-351202", "R-CEL-350562", "R-HSA-350562", "R-BTA-351202"], "pathways": ["R-CEL-351143:r:Agmatine biosynthesis", "R-HSA-351143:r:Agmatine biosynthesis", "R-SPO-351143:r:Agmatine biosynthesis", "R-SPO-351202:r:Metabolism of polyamines", "R-DME-351143:r:Agmatine biosynthesis", "R-CEL-351202:r:Metabolism of polyamines", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-351143:r:Agmatine biosynthesis", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-351202:r:Metabolism of polyamines", "R-DME-351202:r:Metabolism of polyamines", "R-RNO-351202:r:Metabolism of polyamines", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-351202:r:Metabolism of polyamines", "R-MMU-351143:r:Agmatine biosynthesis", "R-SCE-351143:r:Agmatine biosynthesis", "R-DDI-351143:r:Agmatine biosynthesis", "R-MMU-351202:r:Metabolism of polyamines", "R-SCE-351202:r:Metabolism of polyamines", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-BTA-351202:r:Metabolism of polyamines"], "type": "Homologous_superfamily"}, "IPR029067": {"description": "CDC48 domain 2-like superfamily", "go_ids": [], "go_terms": [], "name": "CDC48_domain_2-like_sf", "pathway_ids": ["R-SPO-6807878", "R-HSA-6798695", "R-MMU-204005", "R-HSA-9646399", "R-XTR-532668", "R-MMU-6811438", "R-HSA-5689896", "R-HSA-8951664", "R-CEL-6798695", "R-MMU-110320", "R-DME-8951664", "R-SCE-204005", "R-HSA-9918487", "R-DRE-8951664", "R-RNO-382556", "R-XTR-5689896", "R-MMU-5689896", "R-CEL-532668", "R-CEL-5689877", "R-DME-6811438", "R-CEL-5358346", "R-DME-5689896", "R-CEL-6811434", "R-CEL-9013407", "R-MMU-8951664", "R-CEL-6811440", "R-HSA-6811434", "R-MMU-5689877", "R-CEL-110320", "R-CEL-382556", "R-RNO-5689877", "R-HSA-9678110", "R-XTR-9931269", "R-MMU-3371511", "R-DRE-6798695", "R-DRE-9013407", "R-CEL-204005", "R-XTR-9013407", "R-DME-6807878", "R-MMU-6811434", "R-HSA-532668", "R-HSA-9931269", "R-SCE-6811440", "R-MMU-9013407", "R-DDI-204005", "R-DRE-9931269", "R-SCE-6811434", "R-RNO-6811440", "R-DME-110320", "R-RNO-9013407", "R-HSA-5678895", "R-RNO-6811438", "R-RNO-3371511", "R-SCE-9755511", "R-HSA-9755511", "R-RNO-9931269", "R-HSA-9694614", "R-CEL-6807878", "R-XTR-6798695", "R-MMU-6811440", "R-DDI-6811438", "R-DME-9755511", "R-HSA-8866654", "R-HSA-204005", "R-SCE-8951664", "R-DRE-9755511", "R-SPO-6811438", "R-RNO-532668", "R-RNO-8951664", "R-MMU-9931269", "R-SPO-6811434", "R-MMU-6798695", "R-SPO-8951664", "R-RNO-5689896", "R-RNO-5358346", "R-HSA-5358346", "R-DME-5358346", "R-RNO-6798695", "R-HSA-9013407", "R-DME-204005", "R-HSA-3371511", "R-SCE-8876725", "R-HSA-8876725", "R-DRE-5689877", "R-SCE-5689896", "R-HSA-6811438", "R-DME-416993", "R-DRE-382556", "R-SPO-6798695", "R-XTR-8876725", "R-XTR-382556", "R-DME-382556", "R-SCE-6798695", "R-MMU-9755511", "R-MMU-6807878", "R-DDI-6811434", "R-HSA-6811440", "R-DRE-532668", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-DDI-6811440", "R-DRE-5689896", "R-MMU-532668", "R-SPO-5689896", "R-CEL-6811438", "R-HSA-5689877", "R-DME-9013407", "R-MMU-416993", "R-MMU-382556", "R-HSA-416993", "R-DME-6811440", "R-SCE-6807878", "R-DRE-5358346", "R-DRE-3371511", "R-RNO-6811434", "R-RNO-6807878", "R-CEL-9755511", "R-DME-6798695", "R-RNO-9755511", "R-HSA-382556", "R-HSA-6807878", "R-SPO-204005", "R-CEL-9931269", "R-MMU-9033241", "R-RNO-110320", "R-XTR-8951664", "R-DME-3371511", "R-DME-532668", "R-SPO-8876725", "R-XTR-110320", "R-SPO-6811440", "R-MMU-8876725", "R-SPO-9755511", "R-DME-6811434", "R-RNO-204005", "R-XTR-5358346", "R-DRE-110320", "R-SPO-3371511", "R-DRE-8876725", "R-DDI-6807878", "R-XTR-9755511", "R-SPO-110320", "R-SCE-6811438", "R-SCE-3371511", "R-HSA-110320", "R-HSA-9033241", "R-RNO-416993", "R-CEL-8951664"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-9646399:r:Aggrephagy", "R-XTR-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-6811438:r:Intra-Golgi traffic", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8951664:r:Neddylation", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-DME-8951664:r:Neddylation", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-DRE-8951664:r:Neddylation", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-5689877:r:Josephin domain DUBs", "R-DME-6811438:r:Intra-Golgi traffic", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-9013407:r:RHOH GTPase cycle", "R-MMU-8951664:r:Neddylation", "R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5689877:r:Josephin domain DUBs", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-RNO-5689877:r:Josephin domain DUBs", "R-HSA-9678110:r:Attachment and Entry", "R-XTR-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-3371511:r:HSF1 activation", "R-DRE-6798695:r:Neutrophil degranulation", "R-DRE-9013407:r:RHOH GTPase cycle", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-XTR-9013407:r:RHOH GTPase cycle", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-9013407:r:RHOH GTPase cycle", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-DRE-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-110320:r:Translesion Synthesis by POLH", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-RNO-6811438:r:Intra-Golgi traffic", "R-RNO-3371511:r:HSF1 activation", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9694614:r:Attachment and Entry", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-XTR-6798695:r:Neutrophil degranulation", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-SCE-8951664:r:Neddylation", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-6811438:r:Intra-Golgi traffic", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-8951664:r:Neddylation", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-8951664:r:Neddylation", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-3371511:r:HSF1 activation", "R-SCE-8876725:r:Protein methylation", "R-HSA-8876725:r:Protein methylation", "R-DRE-5689877:r:Josephin domain DUBs", "R-SCE-5689896:r:Ovarian tumor domain proteases", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-SPO-6798695:r:Neutrophil degranulation", "R-XTR-8876725:r:Protein methylation", "R-XTR-382556:r:ABC-family proteins mediated transport", "R-DME-382556:r:ABC-family proteins mediated transport", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-SPO-5689896:r:Ovarian tumor domain proteases", "R-CEL-6811438:r:Intra-Golgi traffic", "R-HSA-5689877:r:Josephin domain DUBs", "R-DME-9013407:r:RHOH GTPase cycle", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-DRE-3371511:r:HSF1 activation", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-XTR-8951664:r:Neddylation", "R-DME-3371511:r:HSF1 activation", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-SPO-8876725:r:Protein methylation", "R-XTR-110320:r:Translesion Synthesis by POLH", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-8876725:r:Protein methylation", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-XTR-5358346:r:Hedgehog ligand biogenesis", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-SPO-3371511:r:HSF1 activation", "R-DRE-8876725:r:Protein methylation", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-XTR-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SCE-6811438:r:Intra-Golgi traffic", "R-SCE-3371511:r:HSF1 activation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-8951664:r:Neddylation"], "type": "Homologous_superfamily"}, "IPR029068": {"description": "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase", "go_ids": [], "go_terms": [], "name": "Glyas_Bleomycin-R_OHBP_Dase", "pathway_ids": ["R-MMU-70268", "R-HSA-8963684", "R-SPO-6798695", "R-BTA-8963684", "R-SCE-70171", "R-SPO-70268", "R-SCE-6798695", "R-RNO-2142789", "R-MMU-2142789", "R-CEL-8963684", "R-DDI-8963684", "R-HSA-70268", "R-DDI-71032", "R-RNO-70268", "R-RNO-8963684", "R-DDI-2142789", "R-MMU-8963684", "R-HSA-71032", "R-HSA-2142789", "R-MMU-71032", "R-SPO-70171", "R-SCE-70268"], "pathways": ["R-MMU-70268:r:Pyruvate metabolism", "R-HSA-8963684:r:Tyrosine catabolism", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-8963684:r:Tyrosine catabolism", "R-SCE-70171:r:Glycolysis", "R-SPO-70268:r:Pyruvate metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-CEL-8963684:r:Tyrosine catabolism", "R-DDI-8963684:r:Tyrosine catabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-DDI-71032:r:Propionyl-CoA catabolism", "R-RNO-70268:r:Pyruvate metabolism", "R-RNO-8963684:r:Tyrosine catabolism", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-MMU-8963684:r:Tyrosine catabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-SPO-70171:r:Glycolysis", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Homologous_superfamily"}, "IPR029069": {"description": "HotDog domain superfamily", "go_ids": [], "go_terms": [], "name": "HotDog_dom_sf", "pathway_ids": ["PWY-7664", "PWY-8175", "PWY-7858", "PWY-8174", "PWY-8203", "PWY-7663", "PWYG-321", "PWY-5971", "PWY-7388", "PWY-5973", "PWY-8427", "PWY-5989", "PWY-8279", "PWY-8280", "PWY-6519", "PWY-6282", "PWY-8173", "R-HSA-165158", "R-DDI-390247", "R-SCE-2046106", "R-RNO-1257604", "R-RNO-2046106", "R-CEL-77289", "R-HSA-193368", "R-DME-2046106", "R-RNO-5218920", "R-MMU-389357", "R-RNO-9033241", "R-MMU-389887", "R-HSA-5218920", "R-RNO-389887", "R-DDI-389887", "R-DDI-193368", "R-RNO-77289", "R-HSA-199418", "R-MMU-165158", "R-SCE-9033241", "R-SCE-193368", "R-DME-390247", "R-DDI-9033241", "R-HSA-77289", "R-RNO-389357", "R-RNO-199418", "R-MMU-2046106", "R-MMU-193368", "R-RNO-165158", "R-MMU-5218920", "R-DDI-2046106", "R-DME-9033241", "R-DME-389887", "R-BTA-77289", "R-SCE-390247", "R-HSA-389887", "R-MMU-1257604", "R-MMU-9033241", "R-SCE-389887", "R-DME-193368", "R-HSA-390247", "R-MMU-390247", "R-RNO-193368", "R-HSA-75105", "R-MMU-77289", "R-HSA-389357", "R-SPO-77289", "R-MMU-199418", "R-HSA-9033500", "R-HSA-1257604", "R-HSA-2046106", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWYG-321:t:mycolate biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-8279:t:palmitate biosynthesis III", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "R-HSA-165158:r:Activation of AKT2", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-SCE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-CEL-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-165158:r:Activation of AKT2", "R-SCE-9033241:r:Peroxisomal protein import", "R-SCE-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-165158:r:Activation of AKT2", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-9033241:r:Peroxisomal protein import", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-9033241:r:Peroxisomal protein import", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Homologous_superfamily"}, "IPR029070": {"description": "Chitinase insertion domain superfamily", "go_ids": [], "go_terms": [], "name": "Chitinase_insertion_sf", "pathway_ids": ["R-MMU-2534343", "R-HSA-6798695", "R-HSA-189085", "R-DRE-114608", "R-DME-6798695", "R-CEL-6798695", "R-SCE-6798695", 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"R-RNO-72649", "R-MMU-9646399", "R-GGA-8866904", "R-BTA-2424491", "R-GGA-975956", "R-SSC-75815", "R-SPO-4615885", "R-HSA-5685942", "R-BTA-5357956", "R-GGA-205043", "R-MMU-8852276", "R-MMU-68949", "R-GGA-8951664", "R-DRE-3108214", "R-BTA-6781823", "R-BTA-5654695", "R-MMU-8874081", "R-DME-209396", "R-HSA-9028335", "R-GGA-9770562", "R-BTA-174184", "R-GGA-3065678", "R-DME-917937", "R-MMU-9824878", "R-BTA-8939236", "R-HSA-5610780", "R-DDI-532668", "R-CFA-182971", "R-DME-350480", "R-MMU-5607761", "R-GGA-5674499", "R-SSC-9758274", "R-MMU-6807004", "R-HSA-5663220", "R-SSC-5696400", "R-HSA-9856530", "R-SPO-3065679", "R-DME-2173796", "R-GGA-9929356", "R-MMU-373752", "R-RNO-195253", "R-CEL-1250342", "R-DME-5654733", "R-GGA-5689896", "R-DDI-5358346", "R-DME-8951664", "R-DME-451806", "R-RNO-9013149", "R-CEL-187577", "R-MMU-9013404", "R-CFA-5654727", "R-CFA-5675221", "R-HSA-3928662", "R-BTA-9929491", "R-DME-5099900", "R-MMU-5654732", "R-GGA-69231", "R-MMU-5684264", "R-MMU-9954714", "R-SSC-5656169", "R-DME-110320", "R-HSA-5654732", "R-DME-179409", "R-RNO-9696273", "R-CEL-9929491", "R-MMU-9705462", "R-MMU-2871837", "R-MMU-6782210", "R-CFA-2559580", "R-RNO-983168", "R-HSA-198203", "R-RNO-4420097", "R-MMU-69231", "R-DME-1169091", "R-HSA-3769402", "R-CEL-8849469", "R-MMU-422356", "R-CFA-5607761", "R-HSA-174184", "R-GGA-9861718", "R-MMU-5610785", "R-HSA-9954709", "R-HSA-5339716", "R-RNO-373752", "R-BTA-168638", "R-MMU-1855204", "R-DDI-1169408", "R-GGA-2173788", "R-DRE-5689880", "R-HSA-201688", "R-HSA-8948747", "R-CEL-9954709", "R-SSC-5696395", "R-BTA-1250342", "R-MMU-5685942", "R-SSC-9929491", "R-HSA-8985586", "R-DDI-9909505", "R-BTA-909733", "R-MMU-9013026", "R-RNO-5610785", "R-DME-5654726", "R-CFA-2559582", "R-CFA-2173796", "R-SSC-3065676", "R-DME-68867", "R-HSA-975163", "R-CFA-2173788", "R-CFA-187577", "R-SSC-5689603", "R-HSA-2559580", "R-HSA-6802952", "R-HSA-912631", "R-HSA-9918487", "R-CFA-69601", "R-MMU-75876", "R-RNO-110314", "R-MMU-8948751", "R-DME-8948751", "R-MMU-937042", "R-RNO-912631", "R-DME-72706", "R-HSA-72695", "R-BTA-1169091", "R-CEL-3134975", "R-DME-350411", "R-DME-2453902", "R-DME-5676590", "R-DME-9664873", "R-HSA-9013507", "R-HSA-2691232", "R-SSC-975144", "R-CFA-6794361", "R-HSA-5607761", "R-DDI-174084", "R-DRE-9793242", "R-MMU-9932298", "R-BTA-72702", "R-SSC-8849469", "R-GGA-5654726", "R-DME-450302", "R-GGA-9954716", "R-HSA-8866654", "R-HSA-9008059", "R-CFA-174113", "R-HSA-3232142", "R-SSC-975957", "R-CEL-6782135", "R-GGA-6804760", "R-RNO-9954709", "R-HSA-389357", "R-SSC-5656121", "R-CEL-8948751", "R-CEL-6811558", "R-MMU-9766229", "R-MMU-354192", "R-DDI-187577", "R-HSA-9833109", "R-RNO-1234176", "R-RNO-4641262", "R-GGA-5685942", "R-CFA-2467813", "R-CEL-5654720", "R-RNO-450321", "R-RNO-5654727", "R-CFA-68949", "R-GGA-5684264", "R-DRE-983168", "R-BTA-9010553", "R-RNO-416482", "R-RNO-3928662", "R-SSC-5689901", "R-SSC-6804756", "R-MMU-975956", "R-MMU-114508", "R-CEL-8856828", "R-HSA-9770562", "R-HSA-5655332", "R-RNO-6796648", "R-HSA-4641263", "R-SPO-4551638", "R-CFA-6782210", "R-HSA-5099900", "R-HSA-1358803", "R-HSA-9634638", "R-DDI-5675221", "R-XTR-8980692", "R-SPO-110320", "R-CFA-937072", "R-CEL-114604", "R-HSA-2173788", "R-BTA-5357905", "R-DME-5689880", "R-HSA-391160", "R-MMU-1253288", "R-RNO-201681", "R-RNO-110312", "R-XTR-4615885", "R-DRE-5674135", "R-RNO-674695", "R-HSA-167238", "R-HSA-5689896", "R-HSA-8856828", "R-BTA-202424", "R-MMU-5689901", "R-RNO-9027276", "R-MMU-5205685", "R-MMU-2565942", "R-HSA-936964", "R-HSA-167287", "R-MMU-5696395", "R-HSA-380994", "R-CEL-5654732", "R-DME-4641262", "R-HSA-6804757", "R-GGA-6782135", "R-DME-4608870", "R-SSC-445989", "R-GGA-8856828", "R-SSC-72706", "R-HSA-9927354", "R-HSA-5603029", "R-HSA-209560", "R-RNO-5205685", "R-CEL-9860927", "R-HSA-9683610", "R-CEL-180292", "R-CFA-382556", "R-HSA-9735869", "R-HSA-4641258", "R-BTA-4641258", "R-MMU-8876198", "R-CEL-5674499", "R-MMU-6798695", "R-RNO-6794361", "R-MMU-1799339", "R-MMU-114608", "R-MMU-5610780", "R-CEL-8863795", "R-HSA-3108214", "R-DDI-1660499", "R-BTA-5654720", "R-DDI-75815", "R-RNO-2029482", "R-BTA-186763", "R-CFA-9758274", "R-GGA-174113", "R-RNO-114508", "R-HSA-432722", "R-BTA-6807004", "R-BTA-174178", "R-DME-170968", "R-XTR-8856828", "R-BTA-3769402", "R-CFA-8948747", "R-HSA-445355", "R-CFA-937039", "R-HSA-2173791", "R-SSC-975956", "R-GGA-434001", "R-CFA-9931295", "R-BTA-8854050", "R-HSA-5627123", "R-CEL-4420097", "R-MMU-9927354", "R-MMU-416482", "R-SSC-8866654", "R-BTA-5607764", "R-RNO-1855204", "R-CEL-8874081", "R-SSC-74751", "R-SSC-9664873", "R-SSC-1253288", "R-HSA-9664422", "R-GGA-75815", "R-CFA-1169091", "R-CEL-5632684", "R-HSA-5689880", "R-CFA-8863795", "R-SSC-6782210", "R-MMU-210993", "R-DME-5654732", "R-DDI-114608", "R-BTA-1963642", "R-MMU-8854214", "R-MMU-4551638", "R-MMU-5663213", "R-DME-1295596", "R-CFA-5689603", "R-MMU-5673001", "R-HSA-1234176", "R-MMU-68867", "R-DME-2559582", "R-BTA-182971", "R-MMU-72163", "R-BTA-6782135", "R-DME-209461", "R-BTA-2173788", "R-HSA-6804760", "R-HSA-72702", "R-HSA-5637810", "R-GGA-937072", "R-GGA-9013507", "R-CFA-5655862", "R-CFA-6781823", "R-SSC-5654733", "R-BTA-917937", "R-CEL-5696395", "R-HSA-5696394", "R-DME-1632852", "R-CFA-5610785", "R-RNO-8851907", "R-DME-69017", "R-RNO-5676590", "R-MMU-430116", "R-MMU-8980692", "R-HSA-2029485", "R-RNO-69601", "R-SSC-349425", "R-HSA-9013423", "R-SSC-9931295", "R-DME-392517", "R-HSA-8851907", "R-CEL-75815", "R-CEL-354192", "R-MMU-512988", "R-CFA-936964", "R-CFA-5357956", "R-SCE-3232118"], "pathways": ["R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-MMU-437239:r:Recycling pathway of L1", "R-CFA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-XTR-201688:r:WNT mediated activation of DVL", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SSC-202424:r:Downstream TCR signaling", "R-DRE-4090294:r:SUMOylation of intracellular receptors", "R-GGA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-CFA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-CEL-9020702:r:Interleukin-1 signaling", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CFA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-4086400:r:PCP/CE pathway", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-9020702:r:Interleukin-1 signaling", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-SSC-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-4641258:r:Degradation of DVL", "R-RNO-8853659:r:RET signaling", "R-GGA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DME-5689877:r:Josephin domain DUBs", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SSC-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-BTA-416476:r:G alpha (q) signalling events", "R-GGA-8948747:r:Regulation of PTEN localization", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-DDI-5689877:r:Josephin domain DUBs", "R-RNO-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-GGA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-5689901:r:Metalloprotease DUBs", "R-SSC-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-GGA-4641258:r:Degradation of DVL", "R-DDI-9770562:r:mRNA Polyadenylation", "R-SSC-8951664:r:Neddylation", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-CFA-110312:r:Translesion synthesis by REV1", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-CFA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-538864:r:Degradation of CRY", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-SSC-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-8951664:r:Neddylation", "R-HSA-3065679:r:SUMO is proteolytically processed", "R-MMU-1632852:r:Macroautophagy", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-CFA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-9770562:r:mRNA Polyadenylation", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-182971:r:EGFR downregulation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-SSC-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-XTR-3065679:r:SUMO is proteolytically processed", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-MMU-171007:r:p38MAPK events", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-XTR-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SSC-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DRE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-4570464:r:SUMOylation of RNA binding proteins", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-3065679:r:SUMO is proteolytically processed", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-CFA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-4085377:r:SUMOylation of SUMOylation proteins", "R-CEL-877312:r:Regulation of IFNG signaling", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-HSA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-CFA-917937:r:Iron uptake and transport", "R-DDI-8951664:r:Neddylation", "R-SSC-4641257:r:Degradation of AXIN", "R-MMU-8951664:r:Neddylation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-5689603:r:UCH proteinases", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-SSC-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CFA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-69481:r:G2/M Checkpoints", "R-GGA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-DRE-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-SPO-5689603:r:UCH proteinases", "R-HSA-5602636:r:IKBKB deficiency causes SCID", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SSC-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-9648002:r:RAS processing", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-CEL-416476:r:G alpha (q) signalling events", "R-CEL-9646399:r:Aggrephagy", "R-GGA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-HSA-5334118:r:DNA methylation", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-MMU-2028269:r:Signaling by Hippo", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-SSC-4641258:r:Degradation of DVL", "R-MMU-9033241:r:Peroxisomal protein import", "R-BTA-5689603:r:UCH proteinases", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-917937:r:Iron uptake and transport", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-8854214:r:TBC/RABGAPs", "R-CFA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-SSC-5673000:r:RAF activation", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-5689896:r:Ovarian tumor domain proteases", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-RNO-9607240:r:FLT3 Signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-5673000:r:RAF activation", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-GGA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-DDI-9033241:r:Peroxisomal protein import", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-GGA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-8983711:r:OAS antiviral response", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-MMU-4086400:r:PCP/CE pathway", "R-BTA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-DRE-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-8951664:r:Neddylation", "R-GGA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9648002:r:RAS processing", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-BTA-9833482:r:PKR-mediated signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-GGA-4090294:r:SUMOylation of intracellular receptors", "R-HSA-2672351:r:Stimuli-sensing channels", "R-RNO-69541:r:Stabilization of p53", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-4085377:r:SUMOylation of SUMOylation proteins", "R-GGA-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-6794361:r:Neurexins and neuroligins", "R-GGA-4755510:r:SUMOylation of immune response proteins", "R-SSC-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9793242:r:SUMOylation of nuclear envelope proteins", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-SSC-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-9706369:r:Negative regulation of FLT3", "R-GGA-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-5696400:r:Dual Incision in GG-NER", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CFA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-182971:r:EGFR downregulation", "R-SSC-9033241:r:Peroxisomal protein import", "R-GGA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-RNO-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-GGA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-418885:r:DCC mediated attractive signaling", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-CFA-2871837:r:FCERI mediated NF-kB activation", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-4641258:r:Degradation of DVL", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CFA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-5689880:r:Ub-specific processing proteases", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CFA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-GGA-182971:r:EGFR downregulation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-GGA-5689901:r:Metalloprotease DUBs", "R-HSA-9646399:r:Aggrephagy", "R-SSC-9607240:r:FLT3 Signaling", "R-SSC-8948751:r:Regulation of PTEN stability and activity", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-418990:r:Adherens junctions interactions", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DME-5655862:r:Translesion synthesis by POLK", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DDI-5689901:r:Metalloprotease DUBs", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9035034:r:RHOF GTPase cycle", "R-CFA-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-4086400:r:PCP/CE pathway", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-5673000:r:RAF activation", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-4641258:r:Degradation of DVL", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-GGA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-GGA-9646399:r:Aggrephagy", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-418594:r:G alpha (i) signalling events", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-XTR-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-3065679:r:SUMO is proteolytically processed", "R-DDI-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CFA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-HSA-112399:r:IRS-mediated signalling", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-CFA-69231:r:Cyclin D associated events in G1", "R-HSA-109704:r:PI3K Cascade", "R-GGA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-CEL-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-170968:r:Frs2-mediated activation", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-8948747:r:Regulation of PTEN localization", "R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-180292:r:GAB1 signalosome", "R-SCE-5689603:r:UCH proteinases", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CFA-4641258:r:Degradation of DVL", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-BTA-9706369:r:Negative regulation of FLT3", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-GGA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-430116:r:GP1b-IX-V activation signalling", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-4641257:r:Degradation of AXIN", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CFA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-3065679:r:SUMO is proteolytically processed", "R-GGA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CFA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DME-430116:r:GP1b-IX-V activation signalling", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9842663:r:Signaling by LTK", "R-SSC-4755510:r:SUMOylation of immune response proteins", "R-RNO-5689603:r:UCH proteinases", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-CFA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-DME-209190:r:Phosphorylation of CI", "R-SSC-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-CEL-2028269:r:Signaling by Hippo", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-GGA-2672351:r:Stimuli-sensing channels", "R-HSA-9793242:r:SUMOylation of nuclear envelope proteins", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-SSC-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-GGA-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-937039:r:IRAK1 recruits IKK complex", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-69481:r:G2/M Checkpoints", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-CFA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-877312:r:Regulation of IFNG signaling", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-110312:r:Translesion synthesis by REV1", "R-BTA-5689901:r:Metalloprotease DUBs", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-BTA-4755510:r:SUMOylation of immune response proteins", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-SCE-8951664:r:Neddylation", "R-GGA-209543:r:p75NTR recruits signalling complexes", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-193648:r:NRAGE signals death through JNK", "R-DME-182971:r:EGFR downregulation", "R-CEL-170968:r:Frs2-mediated activation", "R-CFA-909733:r:Interferon alpha/beta signaling", "R-DME-373752:r:Netrin-1 signaling", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-8854214:r:TBC/RABGAPs", "R-SSC-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9013106:r:RHOC GTPase cycle", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-BTA-4090294:r:SUMOylation of intracellular receptors", "R-RNO-4641257:r:Degradation of AXIN", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-5689603:r:UCH proteinases", "R-SSC-9020702:r:Interleukin-1 signaling", "R-GGA-9033241:r:Peroxisomal protein import", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-5632684:r:Hedgehog 'on' state", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-XTR-4090294:r:SUMOylation of intracellular receptors", "R-RNO-9664873:r:Pexophagy", "R-CFA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-6807004:r:Negative regulation of MET activity", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-109704:r:PI3K Cascade", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-CFA-9706369:r:Negative regulation of FLT3", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-422356:r:Regulation of insulin secretion", "R-DDI-9646399:r:Aggrephagy", "R-XTR-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9833482:r:PKR-mediated signaling", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-201556:r:Signaling by ALK", "R-BTA-9013407:r:RHOH GTPase cycle", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-GGA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CFA-9646399:r:Aggrephagy", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-DDI-68949:r:Orc1 removal from chromatin", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-201688:r:WNT mediated activation of DVL", "R-BTA-9766229:r:Degradation of CDH1", "R-GGA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-CFA-110320:r:Translesion Synthesis by POLH", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-CFA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-GGA-9793242:r:SUMOylation of nuclear envelope proteins", "R-SSC-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-CEL-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-CFA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9833110:r:RSV-host interactions", "R-BTA-373752:r:Netrin-1 signaling", "R-GGA-353299:r:RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SSC-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-SSC-6804757:r:Regulation of TP53 Degradation", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-9664873:r:Pexophagy", "R-SSC-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-4755510:r:SUMOylation of immune response proteins", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-432395:r:Degradation of TIM", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-186763:r:Downstream signal transduction", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-9013026:r:RHOB GTPase cycle", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-MMU-9770562:r:mRNA Polyadenylation", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-CEL-9013407:r:RHOH GTPase cycle", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-432524:r:Degradation of PER", "R-BTA-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-877312:r:Regulation of IFNG signaling", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SSC-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-DME-5689901:r:Metalloprotease DUBs", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-SSC-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-9755511:r:KEAP1-NFE2L2 pathway", "R-DRE-877312:r:Regulation of IFNG signaling", "R-BTA-3899300:r:SUMOylation of transcription cofactors", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-114608:r:Platelet degranulation", "R-GGA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-354192:r:Integrin signaling", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CFA-6804760:r:Regulation of TP53 Activity through Methylation", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-GGA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SSC-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-912631:r:Regulation of signaling by CBL", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-8983711:r:OAS antiviral response", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-CFA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-74749:r:Signal attenuation", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-4641263:r:Regulation of FZD by ubiquitination", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-201688:r:WNT mediated activation of DVL", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-RNO-422356:r:Regulation of insulin secretion", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-5632684:r:Hedgehog 'on' state", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-9664873:r:Pexophagy", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SPO-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-BTA-9033241:r:Peroxisomal protein import", "R-GGA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-XTR-1632852:r:Macroautophagy", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-CEL-110312:r:Translesion synthesis by REV1", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-3232118:r:SUMOylation of transcription factors", "R-SSC-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-GGA-68867:r:Assembly of the pre-replicative complex", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-8948747:r:Regulation of PTEN localization", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-BTA-9646399:r:Aggrephagy", "R-BTA-72649:r:Translation initiation complex formation", "R-CFA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-SPO-1632852:r:Macroautophagy", "R-XTR-2028269:r:Signaling by Hippo", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-DDI-8948747:r:Regulation of PTEN localization", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-CEL-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-GGA-8939902:r:Regulation of RUNX2 expression and activity", "R-GGA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SSC-8853659:r:RET signaling", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5674499:r:Negative feedback regulation of MAPK pathway", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9766229:r:Degradation of CDH1", "R-MMU-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-GGA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-SSC-182971:r:EGFR downregulation", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-68949:r:Orc1 removal from chromatin", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-5685942:r:HDR through Homologous Recombination (HRR)", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SSC-209543:r:p75NTR recruits signalling complexes", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-MMU-69481:r:G2/M Checkpoints", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-1632852:r:Macroautophagy", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-SSC-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9013407:r:RHOH GTPase cycle", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-1295596:r:Spry regulation of FGF signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9664873:r:Pexophagy", "R-SCE-917937:r:Iron uptake and transport", "R-SCE-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-901032:r:ER Quality Control Compartment (ERQC)", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9615710:r:Late endosomal microautophagy", "R-MMU-8983711:r:OAS antiviral response", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SSC-6783310:r:Fanconi Anemia Pathway", "R-SSC-6782135:r:Dual incision in TC-NER", "R-DME-9646399:r:Aggrephagy", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-74713:r:IRS activation", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-SCE-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-9770562:r:mRNA Polyadenylation", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-1989781:r:PPARA activates gene expression", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-RNO-8854214:r:TBC/RABGAPs", "R-DME-209560:r:NF-kB is activated and signals survival", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-9766229:r:Degradation of CDH1", "R-CFA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-CFA-69541:r:Stabilization of p53", "R-RNO-112399:r:IRS-mediated signalling", "R-XTR-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-9020558:r:Interleukin-2 signaling", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-GGA-1227888:r:Negative Regulation of MDA5 signaling", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-5675482:r:Regulation of necroptotic cell death", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-MMU-8853659:r:RET signaling", "R-BTA-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-3065679:r:SUMO is proteolytically processed", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-9793242:r:SUMOylation of nuclear envelope proteins", "R-CFA-912631:r:Regulation of signaling by CBL", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-SSC-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-110312:r:Translesion synthesis by REV1", "R-RNO-418990:r:Adherens junctions interactions", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-DME-209214:r:Phosphorylation of SMO", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-CFA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-9648002:r:RAS processing", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-171007:r:p38MAPK events", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CFA-9766229:r:Degradation of CDH1", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-BTA-5689877:r:Josephin domain DUBs", "R-RNO-180292:r:GAB1 signalosome", "R-MMU-112399:r:IRS-mediated signalling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-RNO-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-SSC-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-GGA-201681:r:TCF dependent signaling in response to WNT", "R-GGA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CFA-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-9732724:r:IFNG signaling activates MAPKs", "R-DDI-8854214:r:TBC/RABGAPs", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-2559585:r:Oncogene Induced Senescence", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-CFA-6807004:r:Negative regulation of MET activity", "R-CFA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-186763:r:Downstream signal transduction", "R-GGA-433871:r:TRAF6 mediated induction of proinflammatory cytokines", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-74713:r:IRS activation", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-BTA-1632852:r:Macroautophagy", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-8980692:r:RHOA GTPase cycle", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-GGA-5673000:r:RAF activation", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-5689901:r:Metalloprotease DUBs", "R-DRE-4641257:r:Degradation of AXIN", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CFA-209560:r:NF-kB is activated and signals survival", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-PFA-1632852:r:Macroautophagy", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-GGA-9020702:r:Interleukin-1 signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-74713:r:IRS activation", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-9664873:r:Pexophagy", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-2173788:r:Downregulation of TGF-beta receptor signaling", "R-GGA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-XTR-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-8951664:r:Neddylation", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-SSC-909733:r:Interferon alpha/beta signaling", "R-DME-912631:r:Regulation of signaling by CBL", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-SSC-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CFA-5656121:r:Translesion synthesis by POLI", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-DME-5673000:r:RAF activation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-CFA-9648002:r:RAS processing", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-CFA-9932298:r:Degradation of CRY and PER proteins", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-CFA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-RNO-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SSC-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-SSC-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-SCE-9793242:r:SUMOylation of nuclear envelope proteins", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9683683:r:Maturation of protein E", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-201688:r:WNT mediated activation of DVL", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-69541:r:Stabilization of p53", "R-SPO-9793242:r:SUMOylation of nuclear envelope proteins", "R-GGA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DRE-4085377:r:SUMOylation of SUMOylation proteins", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-CFA-9861718:r:Regulation of pyruvate metabolism", "R-CFA-937041:r:IKK complex recruitment mediated by RIP1", "R-GGA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-GGA-5632684:r:Hedgehog 'on' state", "R-RNO-5673000:r:RAF activation", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-2424491:r:DAP12 signaling", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SSC-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9664873:r:Pexophagy", "R-MMU-917937:r:Iron uptake and transport", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-SSC-917937:r:Iron uptake and transport", "R-SSC-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-GGA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-6783310:r:Fanconi Anemia Pathway", "R-DDI-1632852:r:Macroautophagy", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-418594:r:G alpha (i) signalling events", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-RNO-9770562:r:mRNA Polyadenylation", "R-SSC-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-69231:r:Cyclin D associated events in G1", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DME-5656121:r:Translesion synthesis by POLI", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-GGA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-3322077:r:Glycogen synthesis", "R-GGA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-GGA-4641257:r:Degradation of AXIN", "R-CFA-6783310:r:Fanconi Anemia Pathway", "R-BTA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CFA-9020702:r:Interleukin-1 signaling", "R-HSA-110312:r:Translesion synthesis by REV1", "R-XTR-4641258:r:Degradation of DVL", "R-CFA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-CEL-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-CEL-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-DRE-4615885:r:SUMOylation of DNA replication proteins", "R-CFA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-CEL-1632852:r:Macroautophagy", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-CFA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-CEL-418885:r:DCC mediated attractive signaling", "R-RNO-2672351:r:Stimuli-sensing channels", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-HSA-354192:r:Integrin signaling", "R-RNO-8948747:r:Regulation of PTEN localization", "R-HSA-193648:r:NRAGE signals death through JNK", "R-SSC-6807004:r:Negative regulation of MET activity", "R-DME-9033241:r:Peroxisomal protein import", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-6794361:r:Neurexins and neuroligins", "R-DRE-4755510:r:SUMOylation of immune response proteins", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-GGA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-XTR-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-5689877:r:Josephin domain DUBs", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-201556:r:Signaling by ALK", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-68949:r:Orc1 removal from chromatin", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-110320:r:Translesion Synthesis by POLH", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-GGA-209560:r:NF-kB is activated and signals survival", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-CEL-4090294:r:SUMOylation of intracellular receptors", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DRE-3232118:r:SUMOylation of transcription factors", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-GGA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-5689877:r:Josephin domain DUBs", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-2028269:r:Signaling by Hippo", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-6807004:r:Negative regulation of MET activity", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-74713:r:IRS activation", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-GGA-392517:r:Rap1 signalling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-5689880:r:Ub-specific processing proteases", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6794361:r:Neurexins and neuroligins", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-BTA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-SSC-8948747:r:Regulation of PTEN localization", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-GGA-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-BTA-8853659:r:RET signaling", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-GGA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-XTR-5689880:r:Ub-specific processing proteases", "R-SPO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-DME-5674135:r:MAP2K and MAPK activation", "R-SPO-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-CEL-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SSC-74749:r:Signal attenuation", "R-SSC-4090294:r:SUMOylation of intracellular receptors", "R-BTA-9648002:r:RAS processing", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-SSC-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-CEL-5689901:r:Metalloprotease DUBs", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-9646399:r:Aggrephagy", "R-SSC-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-4655427:r:SUMOylation of DNA methylation proteins", "R-SSC-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-192823:r:Viral mRNA Translation", "R-CFA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-BTA-201556:r:Signaling by ALK", "R-GGA-353303:r:Nucleotide Excision Repair", "R-CFA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-216167:r:Nuclear CI is degraded", "R-SSC-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-CFA-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-1306955:r:GRB7 events in ERBB2 signaling", "R-BTA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-5689877:r:Josephin domain DUBs", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-202424:r:Downstream TCR signaling", "R-GGA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9033241:r:Peroxisomal protein import", "R-CEL-4641257:r:Degradation of AXIN", "R-CFA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-9696273:r:RND1 GTPase cycle", "R-HSA-9833482:r:PKR-mediated signaling", "R-CFA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-CFA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-SCE-3065679:r:SUMO is proteolytically processed", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-69231:r:Cyclin D associated events in G1", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-SSC-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-68949:r:Orc1 removal from chromatin", "R-CEL-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-CFA-5632684:r:Hedgehog 'on' state", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-RNO-5674499:r:Negative feedback regulation of MAPK pathway", "R-SSC-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-GGA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9020558:r:Interleukin-2 signaling", "R-MMU-912631:r:Regulation of signaling by CBL", "R-CFA-8856828:r:Clathrin-mediated endocytosis", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-XTR-3232118:r:SUMOylation of transcription factors", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-RNO-9646399:r:Aggrephagy", "R-BTA-9607240:r:FLT3 Signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-GGA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-74749:r:Signal attenuation", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-68867:r:Assembly of the pre-replicative complex", "R-MMU-4655427:r:SUMOylation of DNA methylation proteins", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-GGA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-69481:r:G2/M Checkpoints", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-GGA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-GGA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DRE-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5689603:r:UCH proteinases", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-GGA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-418885:r:DCC mediated attractive signaling", "R-SSC-9861718:r:Regulation of pyruvate metabolism", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-SSC-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-CFA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CFA-202424:r:Downstream TCR signaling", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-6807004:r:Negative regulation of MET activity", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-156902:r:Peptide chain elongation", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-8866427:r:VLDLR internalisation and degradation", "R-CEL-3065679:r:SUMO is proteolytically processed", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-BTA-198203:r:PI3K/AKT activation", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-BTA-69481:r:G2/M Checkpoints", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-9766229:r:Degradation of CDH1", "R-HSA-170984:r:ARMS-mediated activation", "R-SPO-8854214:r:TBC/RABGAPs", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-392517:r:Rap1 signalling", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-437239:r:Recycling pathway of L1", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-5358346:r:Hedgehog ligand biogenesis", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-CFA-5654733:r:Negative regulation of FGFR4 signaling", "R-XTR-4086400:r:PCP/CE pathway", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DRE-9013026:r:RHOB GTPase cycle", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-9770562:r:mRNA Polyadenylation", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-SSC-5358346:r:Hedgehog ligand biogenesis", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9706369:r:Negative regulation of FLT3", "R-DDI-9833482:r:PKR-mediated signaling", "R-CFA-68867:r:Assembly of the pre-replicative complex", "R-BTA-180292:r:GAB1 signalosome", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9842663:r:Signaling by LTK", "R-CEL-2672351:r:Stimuli-sensing channels", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CFA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SSC-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-5689877:r:Josephin domain DUBs", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-DDI-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-HSA-373753:r:Nephrin family interactions", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-201556:r:Signaling by ALK", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-DME-437239:r:Recycling pathway of L1", "R-SSC-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-354192:r:Integrin signaling", "R-CFA-5685942:r:HDR through Homologous Recombination (HRR)", "R-SPO-8980692:r:RHOA GTPase cycle", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-BTA-5654726:r:Negative regulation of FGFR1 signaling", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SPO-3232118:r:SUMOylation of transcription factors", "R-GGA-9013407:r:RHOH GTPase cycle", "R-RNO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-CFA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-977225:r:Amyloid fiber formation", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-CFA-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-109704:r:PI3K Cascade", "R-BTA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-2672351:r:Stimuli-sensing channels", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-GGA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-450728:r:Inhibition of actin polymerization", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CFA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CFA-209543:r:p75NTR recruits signalling complexes", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-5603027:r:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "R-RNO-182971:r:EGFR downregulation", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-418885:r:DCC mediated attractive signaling", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-5689603:r:UCH proteinases", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CFA-2672351:r:Stimuli-sensing channels", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SSC-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SCE-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-5673000:r:RAF activation", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-CFA-8866427:r:VLDLR internalisation and degradation", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-CEL-917937:r:Iron uptake and transport", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-4641258:r:Degradation of DVL", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-CEL-9648002:r:RAS processing", "R-SSC-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CFA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-GGA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-5689896:r:Ovarian tumor domain proteases", "R-SSC-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-SSC-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689877:r:Josephin domain DUBs", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-109704:r:PI3K Cascade", "R-CFA-9033241:r:Peroxisomal protein import", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-SSC-9708530:r:Regulation of BACH1 activity", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-CFA-5696400:r:Dual Incision in GG-NER", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-CFA-5689877:r:Josephin domain DUBs", "R-HSA-201556:r:Signaling by ALK", "R-MMU-74749:r:Signal attenuation", "R-SSC-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-3065679:r:SUMO is proteolytically processed", "R-BTA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-3065679:r:SUMO is proteolytically processed", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-9607240:r:FLT3 Signaling", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-9664873:r:Pexophagy", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-CEL-912631:r:Regulation of signaling by CBL", "R-SSC-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-69541:r:Stabilization of p53", "R-DDI-5632684:r:Hedgehog 'on' state", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-392517:r:Rap1 signalling", "R-SSC-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-202424:r:Downstream TCR signaling", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9694493:r:Maturation of protein E", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-912631:r:Regulation of signaling by CBL", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-DDI-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-3232118:r:SUMOylation of transcription factors", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-573298:r:NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation", "R-SPO-2559580:r:Oxidative Stress Induced Senescence", "R-BTA-4570464:r:SUMOylation of RNA binding proteins", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-201688:r:WNT mediated activation of DVL", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-GGA-69541:r:Stabilization of p53", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5689603:r:UCH proteinases", "R-RNO-9013106:r:RHOC GTPase cycle", "R-SSC-2672351:r:Stimuli-sensing channels", "R-SSC-9793242:r:SUMOylation of nuclear envelope proteins", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-392517:r:Rap1 signalling", "R-GGA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-SCE-8854214:r:TBC/RABGAPs", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-MMU-418990:r:Adherens junctions interactions", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CFA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-CFA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-GGA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-5357905:r:Regulation of TNFR1 signaling", "R-SCE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SSC-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-SSC-912631:r:Regulation of signaling by CBL", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-CFA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SCE-1632852:r:Macroautophagy", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SSC-9932298:r:Degradation of CRY and PER proteins", "R-DME-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-SSC-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-GGA-1295596:r:Spry regulation of FGF signaling", "R-DDI-5689880:r:Ub-specific processing proteases", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-9013424:r:RHOV GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-9648002:r:RAS processing", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-CFA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-SSC-5655862:r:Translesion synthesis by POLK", "R-BTA-3232118:r:SUMOylation of transcription factors", "R-BTA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-198203:r:PI3K/AKT activation", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-CFA-9664873:r:Pexophagy", "R-GGA-382556:r:ABC-family proteins mediated transport", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-8948747:r:Regulation of PTEN localization", "R-BTA-112399:r:IRS-mediated signalling", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-CEL-4086400:r:PCP/CE pathway", "R-CFA-6782135:r:Dual incision in TC-NER", "R-CFA-4641257:r:Degradation of AXIN", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-XTR-6798695:r:Neutrophil degranulation", "R-SSC-68949:r:Orc1 removal from chromatin", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-1632852:r:Macroautophagy", "R-CEL-4570464:r:SUMOylation of RNA binding proteins", "R-CFA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-CFA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-110312:r:Translesion synthesis by REV1", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CFA-5689880:r:Ub-specific processing proteases", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-SSC-877312:r:Regulation of IFNG signaling", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-SSC-9706369:r:Negative regulation of FLT3", "R-DME-5689603:r:UCH proteinases", "R-SSC-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-CFA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-171007:r:p38MAPK events", "R-GGA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-XTR-3899300:r:SUMOylation of transcription cofactors", "R-SCE-4551638:r:SUMOylation of chromatin organization proteins", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-SSC-5632684:r:Hedgehog 'on' state", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-5689877:r:Josephin domain DUBs", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-382556:r:ABC-family proteins mediated transport", "R-CEL-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-9648002:r:RAS processing", "R-RNO-72649:r:Translation initiation complex formation", "R-MMU-9646399:r:Aggrephagy", "R-GGA-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-BTA-2424491:r:DAP12 signaling", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-GGA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-68949:r:Orc1 removal from chromatin", "R-GGA-8951664:r:Neddylation", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-DME-209396:r:Phosphorylation of ARM", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-GGA-9770562:r:mRNA Polyadenylation", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DME-917937:r:Iron uptake and transport", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-182971:r:EGFR downregulation", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-GGA-5674499:r:Negative feedback regulation of MAPK pathway", "R-SSC-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-SSC-5696400:r:Dual Incision in GG-NER", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-3065679:r:SUMO is proteolytically processed", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-373752:r:Netrin-1 signaling", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-1250342:r:PI3K events in ERBB4 signaling", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-GGA-5689896:r:Ovarian tumor domain proteases", "R-DDI-5358346:r:Hedgehog ligand biogenesis", "R-DME-8951664:r:Neddylation", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-CFA-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-5675221:r:Negative regulation of MAPK pathway", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-GGA-69231:r:Cyclin D associated events in G1", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-5656169:r:Termination of translesion DNA synthesis", "R-DME-110320:r:Translesion Synthesis by POLH", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-9696273:r:RND1 GTPase cycle", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-422356:r:Regulation of insulin secretion", "R-CFA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-RNO-373752:r:Netrin-1 signaling", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-201688:r:WNT mediated activation of DVL", "R-HSA-8948747:r:Regulation of PTEN localization", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SSC-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-CFA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SSC-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-CFA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CFA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SSC-5689603:r:UCH proteinases", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-912631:r:Regulation of signaling by CBL", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-CFA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-9664873:r:Pexophagy", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-CFA-6794361:r:Neurexins and neuroligins", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-9793242:r:SUMOylation of nuclear envelope proteins", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-SSC-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-9008059:r:Interleukin-37 signaling", "R-CFA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-6782135:r:Dual incision in TC-NER", "R-GGA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-SSC-5656121:r:Translesion synthesis by POLI", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-CFA-2467813:r:Separation of Sister Chromatids", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-68949:r:Orc1 removal from chromatin", "R-GGA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-SSC-5689901:r:Metalloprotease DUBs", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-CFA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-XTR-8980692:r:RHOA GTPase cycle", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-CFA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-RNO-110312:r:Translesion synthesis by REV1", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-5689901:r:Metalloprotease DUBs", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-GGA-6782135:r:Dual incision in TC-NER", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-CEL-180292:r:GAB1 signalosome", "R-CFA-382556:r:ABC-family proteins mediated transport", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-4641258:r:Degradation of DVL", "R-BTA-4641258:r:Degradation of DVL", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6794361:r:Neurexins and neuroligins", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-114608:r:Platelet degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-186763:r:Downstream signal transduction", "R-CFA-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-6807004:r:Negative regulation of MET activity", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-170968:r:Frs2-mediated activation", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-BTA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CFA-8948747:r:Regulation of PTEN localization", "R-HSA-445355:r:Smooth Muscle Contraction", "R-CFA-937039:r:IRAK1 recruits IKK complex", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-SSC-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-SSC-74751:r:Insulin receptor signalling cascade", "R-SSC-9664873:r:Pexophagy", "R-SSC-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-GGA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CFA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CFA-8863795:r:Downregulation of ERBB2 signaling", "R-SSC-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-210993:r:Tie2 Signaling", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-DDI-114608:r:Platelet degranulation", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-8854214:r:TBC/RABGAPs", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-CFA-5689603:r:UCH proteinases", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-182971:r:EGFR downregulation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-GGA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-CFA-5655862:r:Translesion synthesis by POLK", "R-CFA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-5654733:r:Negative regulation of FGFR4 signaling", "R-BTA-917937:r:Iron uptake and transport", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-1632852:r:Macroautophagy", "R-CFA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SSC-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DME-392517:r:Rap1 signalling", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CFA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SCE-3232118:r:SUMOylation of transcription factors"], "type": "Homologous_superfamily"}, "IPR029072": {"description": "YebC-like", "go_ids": [], "go_terms": [], "name": "YebC-like", "pathway_ids": ["R-HSA-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly"], "type": "Homologous_superfamily"}, "IPR029073": {"description": "Protein of unknown function DUF4661", "go_ids": [], "go_terms": [], "name": "DUF4661", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029074": {"description": "Immunity protein 49", "go_ids": [], "go_terms": [], "name": "Imm49", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029075": {"description": "Immunity protein 48", "go_ids": [], "go_terms": [], "name": "Imm48", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029076": {"description": "Immunity protein 47", "go_ids": [], "go_terms": [], "name": "Imm47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029077": {"description": "Immunity protein 45", "go_ids": [], "go_terms": [], "name": "Imm45", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029078": {"description": "Immunity protein 44", "go_ids": [], "go_terms": [], "name": "Imm44", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029079": {"description": "Immunity protein 43", "go_ids": [], "go_terms": [], "name": "Imm43", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029080": {"description": "Immunity protein 40", "go_ids": [], "go_terms": [], "name": "Imm40", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029081": {"description": "Immunity protein 39", "go_ids": [], "go_terms": [], "name": "Imm39", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029082": {"description": "Immunity protein 35", "go_ids": [], "go_terms": [], "name": "Imm35", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029083": {"description": "Immunity protein 32", "go_ids": [], "go_terms": [], "name": "Imm32", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029084": {"description": "Immunity protein 30", "go_ids": [], "go_terms": [], "name": "Imm30", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029085": {"description": "Immunity protein 25", "go_ids": [], "go_terms": [], "name": "Imm25", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029086": {"description": "Immunity protein 19", "go_ids": [], "go_terms": [], "name": "Imm19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029087": {"description": "Immunity protein 17", "go_ids": [], "go_terms": [], "name": "Imm17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029088": {"description": "Immunity protein 12", "go_ids": [], "go_terms": [], "name": "Imm12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029089": {"description": "Protein of unknown function DUF4660", "go_ids": [], "go_terms": [], "name": "DUF4660", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029090": {"description": "Protein of unknown function DUF4659", "go_ids": [], "go_terms": [], "name": "DUF4659", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029091": {"description": "Chromatin assembly factor 1 subunit p150, N-terminal", "go_ids": [], "go_terms": [], "name": "CAF1_p150_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029092": {"description": "ZW10 interactor", "go_ids": ["GO:0007093", "GO:0000776"], "go_terms": ["GO:0007093:mitotic cell cycle checkpoint signaling:P", 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[], "pathways": [], "type": "Family"}, "IPR029094": {"description": "Draxin", "go_ids": ["GO:0016055", "GO:0007411", "GO:0005576"], "go_terms": ["GO:0016055:Wnt signaling pathway:P", "GO:0007411:axon guidance:P", "GO:0005576:extracellular region:C"], "name": "Draxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029095": {"description": "NarX-like, N-terminal", "go_ids": [], "go_terms": [], "name": "NarX-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029096": {"description": "Developmental pluripotency-associated protein 3", "go_ids": [], "go_terms": [], "name": "Dppa3", "pathway_ids": ["R-HSA-9821002"], "pathways": ["R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)"], "type": "Family"}, "IPR029097": {"description": "Bacterial toxin 8", "go_ids": [], "go_terms": [], "name": "Ntox8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029098": {"description": "UDP N-acetylglucosamine O-acyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "Acetyltransf_C", "pathway_ids": ["PWY-8245", "PWY-8073", "PWY-8283"], "pathways": ["PWY-8245:t:lipid IVA biosynthesis (P. gingivalis)", "PWY-8073:t:lipid IVA biosynthesis (P. putida)", "PWY-8283:t:lipid IVA biosynthesis (generic)"], "type": "Domain"}, "IPR029099": {"description": "Ribose-phosphate pyrophosphokinase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Pribosyltran_N", "pathway_ids": ["R-RNO-73843", "R-SCE-73843", "R-XTR-73843", "R-MMU-73843", "R-BTA-73843", "R-SPO-73843", "R-DDI-73843", "R-HSA-73843"], "pathways": ["R-RNO-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-SCE-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-XTR-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-MMU-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-BTA-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-SPO-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-DDI-73843:r:5-Phosphoribose 1-diphosphate biosynthesis", "R-HSA-73843:r:5-Phosphoribose 1-diphosphate biosynthesis"], "type": "Domain"}, "IPR029100": {"description": "Bacterial toxin 50", "go_ids": [], "go_terms": [], "name": "Ntox50", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029101": {"description": "Sigma factor regulator, N-terminal", "go_ids": [], "go_terms": [], "name": "Sigma_reg_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029102": {"description": "Bacterial toxin 4", "go_ids": [], "go_terms": [], "name": "Ntox4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029103": {"description": "Bacterial toxin 47", "go_ids": [], "go_terms": [], "name": "Ntox47", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029104": {"description": "Retro-transcribing virus envelope glycoprotein", "go_ids": [], "go_terms": [], "name": "HERV-K_env", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029105": {"description": "Chromatin assembly factor 1 subunit p150, C-terminal", "go_ids": [], "go_terms": [], "name": "CAF1-p150_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029106": {"description": "Bacterial toxin 43", "go_ids": [], "go_terms": [], "name": "Ntox43", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029107": {"description": "Bacterial toxin 3", "go_ids": [], "go_terms": [], "name": "Ntox3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029108": {"description": "Toxin 37-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ntox37-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029109": {"description": "Bacterial toxin 35", "go_ids": [], "go_terms": [], "name": "Ntox35", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029110": {"description": "Bacterial toxin 33", "go_ids": [], "go_terms": [], "name": "Ntox33", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029111": {"description": "Bacterial toxin 30", "go_ids": [], "go_terms": [], "name": "Ntox30", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029112": {"description": "Bacterial toxin 27", "go_ids": [], "go_terms": [], "name": "Ntox27", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029113": {"description": "Bacterial toxin 25", "go_ids": [], "go_terms": [], "name": "Ntox25", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029114": {"description": "Bacterial toxin 24", "go_ids": [], "go_terms": [], "name": "Ntox24", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029115": {"description": "Bacterial toxin 23", "go_ids": [], "go_terms": [], "name": "Ntox23", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029116": {"description": "Bacterial toxin 22", "go_ids": [], "go_terms": [], "name": "Ntox22", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029117": {"description": "Novel toxin 17", "go_ids": [], "go_terms": [], "name": "Ntox17", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029118": {"description": "Novel toxin 16", "go_ids": [], "go_terms": [], "name": "Ntox16", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029119": {"description": "Adenine DNA glycosylase, C-terminal", "go_ids": [], "go_terms": [], "name": "MutY_C", "pathway_ids": ["R-HSA-110331", "R-HSA-110357", "R-HSA-9608287", "R-RNO-110331", "R-HSA-9608290", "R-HSA-110330", "R-RNO-110357", "R-SPO-110331", "R-MMU-110331", "R-MMU-110357"], "pathways": ["R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9608287:r:Defective MUTYH substrate binding", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-9608290:r:Defective MUTYH substrate processing", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-SPO-110331:r:Cleavage of the damaged purine", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1"], "type": "Domain"}, "IPR029120": {"description": "Novel toxin 14", "go_ids": [], "go_terms": [], "name": "Ntox14", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029121": {"description": "Novel toxin 11", "go_ids": [], "go_terms": [], "name": "Ntox11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029122": {"description": "Novel toxin 10", "go_ids": [], "go_terms": [], "name": "Ntox10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029123": {"description": "Splicing factor RBM39, linker", "go_ids": [], "go_terms": [], "name": "RBM39_linker", "pathway_ids": ["R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-MMU-9013408", "R-MMU-9013404", "R-MMU-9013423", "R-SPO-9770562", "R-HSA-72163", "R-SPO-9696273", "R-MMU-2980766", "R-MMU-4419969", "R-MMU-9696270", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-9013149", "R-MMU-2995383"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9696273:r:RND1 GTPase cycle", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation"], "type": "Domain"}, "IPR029124": {"description": "RNA-directed RNA polymerase L, N-terminal", "go_ids": [], "go_terms": [], "name": "L_protein_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029125": {"description": "TBP-interacting protein, N-terminal", "go_ids": [], "go_terms": [], "name": "TIP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029126": {"description": "Restriction endonuclease BpuSI, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BpuSI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029127": {"description": "MvaI/BcnI restriction endonuclease", "go_ids": [], "go_terms": [], "name": "MvaI_BcnI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029128": {"description": "Type II restriction endonuclease subunit R", "go_ids": [], "go_terms": [], "name": "Type_II_R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029129": {"description": "Chromatin assembly factor 1 subunit B, C-terminal", "go_ids": [], "go_terms": [], "name": "CAF1_p60_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029130": {"description": "Acid ceramidase, N-terminal", "go_ids": [], "go_terms": [], "name": "Acid_ceramidase_N", "pathway_ids": ["PWY-6483", "PWY-7119", "R-HSA-6798695", "R-BTA-9840310", "R-RNO-9840310", "R-MMU-9840310", "R-CEL-112310", "R-CEL-9840310", "R-HSA-9840310", "R-CEL-6798695", "R-HSA-9857377", "R-MMU-6798695", "R-BTA-6798695", "R-HSA-112310", "R-RNO-112310", "R-MMU-112310", "R-RNO-6798695"], "pathways": ["PWY-6483:t:ceramide degradation (generic)", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-CEL-112310:r:Neurotransmitter release cycle", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-112310:r:Neurotransmitter release cycle", "R-RNO-112310:r:Neurotransmitter release cycle", "R-MMU-112310:r:Neurotransmitter release cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR029131": {"description": "HAUS augmin-like complex subunit 5", "go_ids": ["GO:0070652", "GO:0051225"], "go_terms": ["GO:0070652:HAUS complex:C", "GO:0051225:spindle assembly:P"], "name": "HAUS5", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-2565942", "R-MMU-8854518", "R-HSA-380284", "R-MMU-380270", "R-MMU-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR029132": {"description": "Choloylglycine hydrolase/NAAA C-terminal", "go_ids": [], "go_terms": [], "name": "CBAH/NAAA_C", "pathway_ids": ["R-HSA-6798695", "R-BTA-9840310", "R-RNO-9840310", "R-MMU-9840310", "R-CEL-112310", "R-CEL-9840310", "R-HSA-9840310", "R-CEL-6798695", "R-HSA-9857377", "R-MMU-6798695", "R-BTA-6798695", "R-HSA-112310", "R-MMU-112310", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-CEL-112310:r:Neurotransmitter release cycle", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-112310:r:Neurotransmitter release cycle", "R-MMU-112310:r:Neurotransmitter release cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR029133": {"description": "Overexpressed in colon carcinoma 1", "go_ids": [], "go_terms": [], "name": "OCC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029134": {"description": "Protein of unknown function DUF4647", "go_ids": [], "go_terms": [], "name": "DUF4647", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029135": {"description": "Protein phosphatase 1 regulatory subunit 35, C-terminal", "go_ids": [], "go_terms": [], "name": "PPP1R35_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029136": {"description": "Nuclear protein MDM1", "go_ids": ["GO:0008017", "GO:0046600"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0046600:negative regulation of centriole replication:P"], "name": "MDM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029137": {"description": "Putative RNase-like toxin, toxin1", "go_ids": [], "go_terms": [], "name": "Ntox1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029138": {"description": "snRNA-activating protein complex subunit 5", "go_ids": ["GO:0006384", "GO:0006366", "GO:0005634"], "go_terms": ["GO:0006384:transcription initiation at RNA polymerase III promoter:P", "GO:0006366:transcription by RNA polymerase II:P", "GO:0005634:nucleus:C"], "name": "SNAPC5", "pathway_ids": ["R-HSA-76071", "R-MMU-76071", "R-BTA-76071", "R-HSA-749476", "R-HSA-6807505", "R-BTA-6807505", "R-MMU-6807505"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR029139": {"description": "NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal", "go_ids": [], "go_terms": [], "name": "QueF_N", "pathway_ids": ["PWY-6700"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)"], "type": "Domain"}, "IPR029140": {"description": "Minor fimbrium subunit Mfa1, C-terminal", "go_ids": [], "go_terms": [], "name": "Mfa1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029141": {"description": "Major fimbrial subunit protein, N-terminal", "go_ids": [], "go_terms": [], "name": "FimA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029142": {"description": "Small proline-rich protein 2", "go_ids": ["GO:0001533"], "go_terms": ["GO:0001533:cornified envelope:C"], "name": "SPRR2", "pathway_ids": ["R-HSA-9725554", "R-HSA-6809371"], "pathways": ["R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Family"}, "IPR029143": {"description": "Protein of unknown function, YrpD", "go_ids": [], "go_terms": [], "name": "YrpD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029144": {"description": "Threonine synthase, N-terminal", "go_ids": [], "go_terms": [], "name": "Thr_synth_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029145": {"description": "Neuroblastoma-amplified sequence, N-terminal", "go_ids": [], "go_terms": [], "name": "NBAS_N", "pathway_ids": ["R-DRE-6811434", "R-HSA-6811434"], "pathways": ["R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR029146": {"description": "CST complex subunit Ten1, animal and plant type", "go_ids": ["GO:1990879", "GO:0003697"], "go_terms": ["GO:1990879:CST complex:C", "GO:0003697:single-stranded DNA binding:F"], "name": "Ten1_animal_plant", "pathway_ids": ["R-MMU-174411", "R-MMU-174430", "R-HSA-174430", "R-HSA-174411"], "pathways": ["R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere"], "type": "Family"}, "IPR029147": {"description": "Cilia- and flagella-associated protein 77", "go_ids": [], "go_terms": [], "name": "CFAP77", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029148": {"description": "FACT complex subunit SPT16, N-terminal lobe domain", "go_ids": [], "go_terms": [], "name": "FACT-SPT16_Nlobe", "pathway_ids": ["R-CEL-75955", "R-SPO-674695", "R-MMU-6796648", "R-DME-674695", "R-HSA-167238", "R-HSA-167243", "R-DME-6796648", "R-SCE-6804756", "R-MMU-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-6804756", "R-DDI-674695", "R-CEL-112382", "R-HSA-167152", "R-SCE-674695", "R-DDI-6796648", "R-HSA-75955", "R-DDI-6804756", "R-CEL-6804756", "R-SPO-6796648", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382", "R-SCE-6796648"], "pathways": ["R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II 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{"description": "Spermatogenesis-associated protein 25", "go_ids": [], "go_terms": [], "name": "SPATA25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029193": {"description": "Testis-expressed sequence 12 protein", "go_ids": [], "go_terms": [], "name": "TEX12", "pathway_ids": ["R-HSA-1221632"], "pathways": ["R-HSA-1221632:r:Meiotic synapsis"], "type": "Family"}, "IPR029194": {"description": "Lens epithelial cell protein LEP503", "go_ids": ["GO:0007275"], "go_terms": ["GO:0007275:multicellular organism development:P"], "name": "LEP503", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029195": {"description": "Host cell factor C1 regulator 1", "go_ids": [], "go_terms": [], "name": "HCFC1R1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029196": {"description": "HUWE1-associated protein modifying stress responses-like", "go_ids": [], "go_terms": [], "name": "HAPSTR1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029197": {"description": "Cytoskeleton-associated protein 2, C-terminal", "go_ids": [], "go_terms": [], "name": "CKAP2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029198": {"description": "AJAP1/PANP, C-terminal", "go_ids": [], "go_terms": [], "name": "AJAP1_PANP_C", "pathway_ids": ["R-RNO-198933", "R-HSA-198933", "R-MMU-198933"], "pathways": ["R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Domain"}, "IPR029199": {"description": "THRAP3/BCLAF1 family", "go_ids": [], "go_terms": [], "name": "THRAP3_BCLAF1", "pathway_ids": ["R-HSA-1989781", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR029200": {"description": "Transmembrane protein 247", "go_ids": [], "go_terms": [], "name": "TMEM247", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029201": {"description": "Jiraiya", "go_ids": [], "go_terms": [], "name": "Jiraiya", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029202": {"description": "Protein of unknown function DUF4530", "go_ids": [], "go_terms": [], "name": "DUF4530", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029203": {"description": "Tektin bundle-interacting protein 1", "go_ids": [], "go_terms": [], "name": "TKTI1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029204": {"description": "CB1 cannabinoid receptor-interacting protein 1", "go_ids": [], "go_terms": [], "name": "CNRIP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029205": {"description": "Aftiphilin, clathrin-binding box", "go_ids": [], "go_terms": [], "name": "Clathrin-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029206": {"description": "Protein of unknown function DUF4532", "go_ids": [], "go_terms": [], "name": "DUF4532", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029207": {"description": "FAM198 family", "go_ids": [], "go_terms": [], "name": "FAM198", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029208": {"description": "Cytochrome c oxidase assembly protein COX14", "go_ids": [], "go_terms": [], "name": "COX14", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848", "R-BTA-9864848", "R-DRE-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-DRE-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR029209": {"description": "DML1/Misato, tubulin domain", "go_ids": [], "go_terms": [], "name": "DML1/Misato_tubulin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029210": {"description": "Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment", "go_ids": [], "go_terms": [], "name": "PfEMP1_NTS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029211": {"description": "Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment", "go_ids": [], "go_terms": [], "name": "PfEMP1_ATS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029212": {"description": "Rho guanine nucleotide exchange factor 5/35, N-terminal", "go_ids": [], "go_terms": [], "name": "ARHGEF5/35_N", "pathway_ids": ["R-HSA-193648", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013106", "R-MMU-9013026", "R-MMU-416482", "R-MMU-8980692", "R-MMU-193648", "R-HSA-9013148", "R-HSA-9013026", "R-MMU-9013408", "R-HSA-416482", "R-HSA-9013408", "R-MMU-9013148", "R-HSA-9013106", "R-MMU-9013149"], "pathways": ["R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR029213": {"description": "Cell-cell fusogen EFF/AFF", "go_ids": [], "go_terms": [], "name": "Fusogen_EFF/AFF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029214": {"description": "Cilia- and flagella-associated protein 144", "go_ids": [], "go_terms": [], "name": "CFAP144", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029215": {"description": "High mobility group box domain 5", "go_ids": [], "go_terms": [], "name": "HMG_box_5", "pathway_ids": ["R-HSA-73728", "R-HSA-73772", "R-HSA-73863", "R-MMU-73762", "R-RNO-73772", "R-MMU-73728", "R-HSA-427413", "R-MMU-73863", "R-RNO-73728", "R-MMU-73772", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762"], "pathways": ["R-HSA-73728:r:RNA Polymerase I Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-73728:r:RNA Polymerase I Promoter Opening", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-73728:r:RNA Polymerase I Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Domain"}, "IPR029216": {"description": "Phytoplasma antigenic membrane protein", "go_ids": [], "go_terms": [], "name": "Phyto-Amp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029217": {"description": "Sporulation-specific protein 71, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Spo7_2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029218": {"description": "Penicillin-binding protein Tp47, domain C", "go_ids": [], "go_terms": [], "name": "PBP-Tp47_dom_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029219": {"description": "UNC119-binding protein", "go_ids": [], "go_terms": [], "name": "UNC119-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029220": {"description": "Penicillin-binding protein Tp47, domain D", "go_ids": [], "go_terms": [], "name": "BP-Tp47_dom_D", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR029221": {"description": "Penicillin-binding protein Tp47 domain A", "go_ids": [], "go_terms": [], "name": "PBP-Tp47_A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029222": {"description": "VCF1/2-like", "go_ids": [], "go_terms": [], "name": "VCF1/2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029224": {"description": "Pilus-assembly complex, chaperone PapJ", "go_ids": [], "go_terms": [], "name": "PapJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029225": {"description": "Nse4/EID protein, Nse3/MAGE-binding domain", "go_ids": [], "go_terms": [], "name": "Nse4_Nse3-bd", "pathway_ids": ["R-SCE-3108214", "R-MMU-3108214", "R-BTA-3108214", "R-RNO-3108214", "R-HSA-3108214"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Domain"}, "IPR029226": {"description": "Secreted effector CE11-like", "go_ids": [], "go_terms": [], "name": "CE11-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029227": {"description": "Plant antimicrobial peptide", "go_ids": ["GO:0050832"], "go_terms": ["GO:0050832:defense response to fungus:P"], "name": "Plant_Antimicrobial", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029228": {"description": "Alkyl sulfatase dimerisation domain", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "Alkyl_sulf_dimr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029229": {"description": "Alkyl sulfatase, C-terminal", "go_ids": [], "go_terms": [], "name": "Alkyl_sulf_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029230": {"description": "Macin", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "Macin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029231": {"description": "Fimbrillin-like", "go_ids": [], "go_terms": [], "name": "Mfa-like_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029234": {"description": "Ciliary microtubule inner protein 4", "go_ids": [], "go_terms": [], "name": "CIMIP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029235": {"description": "Factor associated with metabolism and energy", "go_ids": [], "go_terms": [], "name": "FAME", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029236": {"description": "Protein of unknown function DUF4618", "go_ids": [], "go_terms": [], "name": "DUF4618", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029237": {"description": "Long chain scorpion toxin, cysteine-stabilized alpha/beta domain", "go_ids": [], "go_terms": [], "name": "Long_scorpion_toxin_alpha/beta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029238": {"description": "Shadow of prion protein", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Shadoo", "pathway_ids": ["R-MMU-163125", "R-RNO-163125", "R-BTA-163125", "R-GGA-163125", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR029239": {"description": "Cilia- and flagella-associated protein 418", "go_ids": [], "go_terms": [], "name": "CFAP418", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029240": {"description": "MMS19, N-terminal", "go_ids": [], "go_terms": [], "name": "MMS19_N", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Domain"}, "IPR029241": {"description": "Testis-specific gene 13 protein", "go_ids": [], "go_terms": [], "name": "TSGA13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029242": {"description": "Protein melan-A", "go_ids": ["GO:0042470"], "go_terms": ["GO:0042470:melanosome:C"], "name": "MLANA", "pathway_ids": ["R-HSA-9824585"], "pathways": ["R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation"], "type": "Family"}, "IPR029243": {"description": "Lantibiotic alpha component", "go_ids": ["GO:0050830"], "go_terms": ["GO:0050830:defense response to Gram-positive bacterium:P"], "name": "Lantibiotic_alpha", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029244": {"description": "FAM69, N-terminal", "go_ids": [], "go_terms": [], "name": "FAM69_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029245": {"description": "Protein of unknown function DUF4528", "go_ids": [], "go_terms": [], "name": "DUF4528", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029246": {"description": "Protein TALPID3", "go_ids": ["GO:0007224"], "go_terms": ["GO:0007224:smoothened signaling pathway:P"], "name": "TALPID3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029247": {"description": "FAM168A/MANI", "go_ids": [], "go_terms": [], "name": "FAM168A/MANI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029248": {"description": "Transmembrane protein 107", "go_ids": [], "go_terms": [], "name": "TMEM107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029249": {"description": "Rotatin, N-terminal", "go_ids": [], "go_terms": [], "name": "Rotatin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029250": {"description": "Exosomal polycystin-1-interacting protein", "go_ids": [], "go_terms": [], "name": "ECPIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029251": {"description": "Fanconi anemia-associated protein of 100kDa", "go_ids": ["GO:0043240", "GO:0036297"], "go_terms": ["GO:0043240:Fanconi anaemia nuclear complex:C", "GO:0036297:interstrand cross-link repair:P"], "name": "Faap100", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR029252": {"description": "Regulator of cell cycle RGCC", "go_ids": ["GO:0051726"], "go_terms": ["GO:0051726:regulation of cell cycle:P"], "name": "RGCC", "pathway_ids": ["R-HSA-6804115"], "pathways": ["R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Family"}, "IPR029253": {"description": "Cytokine-like protein 1", "go_ids": [], "go_terms": [], "name": "CYTL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029254": {"description": "MORF4 family-associated protein 1", "go_ids": [], "go_terms": [], "name": "MRFAP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029255": {"description": "Ceroid-lipofuscinosis neuronal protein 6", "go_ids": [], "go_terms": [], "name": "CLN6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029256": {"description": "Helicase-associated putative binding domain", "go_ids": [], "go_terms": [], "name": "Heliccase-ass-bd", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR029257": {"description": "Rab3GAP regulatory subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "RAB3GAP2_C", "pathway_ids": ["R-RNO-6811436", "R-MMU-8876198", "R-CEL-8876198", "R-DME-6811436", "R-DME-8876198", "R-CEL-6811436", "R-RNO-8876198", "R-HSA-8876198", "R-HSA-6811436", "R-MMU-6811436"], "pathways": ["R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR029259": {"description": "Rapamycin-insensitive companion of mTOR, phosphorylation-site", "go_ids": [], "go_terms": [], "name": "RICTOR_phospho", "pathway_ids": ["R-MMU-389357", "R-HSA-5218920", "R-MMU-9856530", "R-MMU-5218920", "R-HSA-6804757", "R-HSA-5674400", "R-MMU-6804757", "R-HSA-389357", "R-HSA-9920951", "R-HSA-9856530", "R-MMU-1257604", "R-HSA-1257604"], "pathways": ["R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling"], "type": "PTM"}, "IPR029260": {"description": "Dual specificity/tyrosine protein phosphatase, N-terminal", "go_ids": [], "go_terms": [], "name": "DSPn", "pathway_ids": ["R-DRE-5687128", "R-DRE-176407", "R-HSA-5687128", "R-SPO-5687128", "R-SPO-176407", "R-SCE-176407", "R-SCE-5687128", "R-MMU-5687128", "R-HSA-176407", "R-CEL-176407", "R-MMU-176407"], "pathways": ["R-DRE-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-SCE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-CEL-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "type": "Domain"}, "IPR029261": {"description": "Transposase IS204/IS1001/IS1096/IS1165, zinc-finger", "go_ids": [], "go_terms": [], "name": "Transposase_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029262": {"description": "DNA-directed RNA polymerase, N-terminal", "go_ids": [], "go_terms": [], "name": "RPOL_N", "pathway_ids": ["R-MMU-9913635", "R-MMU-163282", "R-SPO-163282", "R-HSA-2151201", "R-SCE-163282", "R-HSA-163282", "R-HSA-9913635"], "pathways": ["R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-163282:r:Mitochondrial transcription initiation", "R-SPO-163282:r:Mitochondrial transcription initiation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SCE-163282:r:Mitochondrial transcription initiation", "R-HSA-163282:r:Mitochondrial transcription initiation", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR029263": {"description": "Respiratory nitrate reductase beta, C-terminal", "go_ids": [], "go_terms": [], "name": "Nitr_red_bet_C", "pathway_ids": ["PWY-6748"], "pathways": ["PWY-6748:t:nitrate reduction VII (denitrification)"], "type": "Domain"}, "IPR029264": {"description": "ARF7 effector protein, C-terminal", "go_ids": [], "go_terms": [], "name": "ARF7EP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029265": {"description": "Transmembrane protein 51", "go_ids": [], "go_terms": [], "name": "TMEM51", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029266": {"description": "FAM217 family", "go_ids": [], "go_terms": [], "name": "FAM217", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029267": {"description": "FAM212 domain", "go_ids": [], "go_terms": [], "name": "FAM212", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029268": {"description": "Small muscular protein Chisel", "go_ids": [], "go_terms": [], "name": "Chisel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029269": {"description": "Putative treble-clef, zinc-finger domain", "go_ids": [], "go_terms": [], "name": "Zf-tcix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029270": {"description": "Limb expression 1", "go_ids": [], "go_terms": [], "name": "LIX1", "pathway_ids": ["R-DME-390150"], "pathways": ["R-DME-390150:r:DS ligand bound to FT receptor"], "type": "Family"}, "IPR029271": {"description": "Psoriasis 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[], "pathways": [], "type": "Family"}, "IPR029281": {"description": "FAM194, C-terminal", "go_ids": [], "go_terms": [], "name": "FAM194_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029282": {"description": "Equatorin", "go_ids": ["GO:0005886", "GO:0060478", "GO:0006897", "GO:0007342"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0060478:acrosomal vesicle exocytosis:P", "GO:0006897:endocytosis:P", "GO:0007342:fusion of sperm to egg plasma membrane involved in single fertilization:P"], "name": "Eqtn/Afaf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029283": {"description": "Calcium-dependent cell adhesion molecule 1, membrane-binding domain", "go_ids": [], "go_terms": [], "name": "Membrane-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029284": {"description": "p53-regulated apoptosis-inducing protein 1", "go_ids": [], "go_terms": [], "name": "TP53AIP1", "pathway_ids": ["R-HSA-6803204"], "pathways": ["R-HSA-6803204:r:TP53 Regulates 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"IPR029300": {"description": "CEP170, C-terminal", "go_ids": [], "go_terms": [], "name": "CEP170_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029301": {"description": "Sperm acrosome-associated protein 7", "go_ids": ["GO:0001669"], "go_terms": ["GO:0001669:acrosomal vesicle:C"], "name": "SPACA7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029302": {"description": "Intraflagellar transport protein 43", "go_ids": ["GO:0030991"], "go_terms": ["GO:0030991:intraciliary transport particle A:C"], "name": "IFT43", "pathway_ids": ["R-XTR-5620924", "R-MMU-5620924", "R-HSA-5620924"], "pathways": ["R-XTR-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR029303": {"description": "Capsular polysaccharide assembling protein CapF, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CapF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029304": {"description": "A-kinase anchor protein 2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AKAP2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029305": {"description": "FANCI solenoid 1 cap", "go_ids": [], "go_terms": [], "name": "FANCI_S1-cap", "pathway_ids": ["R-GGA-351465", "R-HSA-6783310", "R-HSA-6796648", "R-MMU-6783310"], "pathways": ["R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR029306": {"description": "E3 ubiquitin-protein ligase Arkadia, N-terminal", "go_ids": [], "go_terms": [], "name": "RNF111_N", "pathway_ids": ["PWY-7511", "R-MMU-5696395", "R-XTR-983168", "R-HSA-2173795", "R-HSA-5696395", "R-MMU-2173796", "R-MMU-983168", "R-XTR-2173796", "R-HSA-983168", "R-HSA-2173796"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "type": "Domain"}, "IPR029307": {"description": "INTS6/SAGE1/DDX26B/CT45, C-terminal", "go_ids": [], "go_terms": [], "name": "INT_SG_DDX_CT_C", "pathway_ids": ["R-DME-6807505", "R-MMU-6807505", "R-HSA-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR029308": {"description": "FANCI solenoid 1 domain", "go_ids": [], "go_terms": [], "name": "FANCI_S1", "pathway_ids": ["R-GGA-351465", "R-HSA-6796648", "R-HSA-6783310", "R-DME-6783310", "R-MMU-6783310"], "pathways": ["R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR029309": {"description": "Calcium-responsive transcription factor", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "CaRF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029310": {"description": "FANCI helical domain 1", "go_ids": [], "go_terms": [], "name": "FANCI_HD1", "pathway_ids": ["R-GGA-351465", "R-HSA-6783310", "R-HSA-6796648", "R-MMU-6783310"], "pathways": ["R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR029311": {"description": "Coiled-coil domain-containing protein 50, N-terminal", "go_ids": [], "go_terms": [], "name": "CCDC50_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029312": {"description": "FANCI helical domain 2", "go_ids": [], "go_terms": [], "name": "FANCI_HD2", "pathway_ids": ["R-GGA-351465", "R-HSA-6796648", "R-HSA-6783310", "R-DME-6783310", "R-MMU-6783310"], "pathways": ["R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR029313": {"description": "FANCI solenoid 3 domain", "go_ids": [], "go_terms": [], "name": "FANCI_S3", "pathway_ids": ["R-GGA-351465", "R-HSA-6796648", "R-HSA-6783310", "R-DME-6783310", "R-MMU-6783310"], "pathways": ["R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR029314": {"description": "FANCI solenoid 4 domain", "go_ids": [], "go_terms": [], "name": "FANCI_S4", "pathway_ids": ["R-GGA-351465", "R-HSA-6796648", "R-HSA-6783310", "R-DME-6783310", "R-MMU-6783310"], "pathways": ["R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR029315": {"description": "FANCI solenoid 2 domain", "go_ids": [], "go_terms": [], "name": "FANCI_S2", "pathway_ids": ["R-GGA-351465", "R-HSA-6796648", "R-HSA-6783310", "R-DME-6783310", "R-MMU-6783310"], "pathways": ["R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR029316": {"description": "Regulatory factor X-associated protein, RFXANK-binding domain", "go_ids": [], "go_terms": [], "name": "RFXAP_RFXANK-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029317": {"description": "KRBA1 family repeat", "go_ids": [], "go_terms": [], "name": "KRBA1_rpt", "pathway_ids": ["R-MMU-212436", "R-HSA-212436"], "pathways": ["R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway"], "type": "Repeat"}, "IPR029318": {"description": "Beclin-1, BH3 domain", "go_ids": [], "go_terms": [], "name": "BH3_dom", "pathway_ids": ["R-DRE-5689880", "R-HSA-9694676", "R-HSA-9705671", "R-BTA-5689880", "R-HSA-5689880", "R-MMU-1632852", "R-RNO-1169408", "R-HSA-1169408", "R-MMU-1169408", "R-BTA-1632852", "R-RNO-5689880", "R-MMU-5689880", "R-HSA-983170", "R-RNO-1632852", "R-XTR-1632852", "R-HSA-1632852", "R-HSA-9833110", "R-HSA-9920951", "R-BTA-1169408", "R-HSA-9679504"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-1632852:r:Macroautophagy", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-BTA-1632852:r:Macroautophagy", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR029319": {"description": "DNA ligase, OB-like domain", "go_ids": [], "go_terms": [], "name": "DNA_ligase_OB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029320": {"description": "Acyl-coenzyme A oxidase, N-terminal", "go_ids": [], "go_terms": [], "name": "Acyl-CoA_ox_N", "pathway_ids": ["PWY-7858", "PWY-7291", "PWY-7288", "PWY-6920", "PWY-7007", "PWY-7574", "PWY-735", "PWY-7854", "PWY-6837", "PWY-5136", "PWY-7337", "PWY-7338", "PWY-7340", "PWY-7606", "PWY-7726", "R-HSA-1989781", "R-MMU-2046106", "R-MMU-193368", "R-DDI-390247", "R-DDI-2046106", "R-DME-9033241", "R-DME-389887", "R-RNO-2046106", "R-HSA-389887", "R-HSA-193368", "R-BTA-2046106", "R-DME-2046106", "R-MMU-9033241", "R-CEL-390247", "R-BTA-9033241", "R-CEL-2046106", "R-CEL-193368", "R-RNO-9033241", "R-MMU-389887", "R-SCE-389887", "R-DME-193368", "R-RNO-389887", "R-DDI-389887", "R-DDI-193368", "R-HSA-390247", "R-MMU-390247", "R-RNO-193368", "R-BTA-390247", "R-CEL-389887", "R-HSA-9033500", "R-HSA-2046106", "R-DME-390247", "R-DDI-9033241", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-7291:t:oleate beta-oxidation (isomerase-dependent, yeast)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7574:t:propanoyl-CoA degradation II", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-6837:t:fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-9033241:r:Peroxisomal protein import", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-CEL-390247:r:Beta-oxidation of very long chain fatty acids", "R-BTA-9033241:r:Peroxisomal protein import", "R-CEL-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-CEL-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR029321": {"description": "Integrator complex subunit 2", "go_ids": ["GO:0032039"], "go_terms": ["GO:0032039:integrator complex:C"], "name": "INTS2", "pathway_ids": ["R-DME-6807505", "R-GGA-6807505", "R-HSA-6807505", "R-MMU-6807505", "R-DDI-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR029322": {"description": "Domain of unknown function DUF4474", "go_ids": [], "go_terms": [], "name": "DUF4474", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029323": {"description": "Equine arteritis virus, non-structural protein 1", "go_ids": [], "go_terms": [], "name": "EAV_nsp1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029324": {"description": "Mitochondrial apoptosis-inducing factor, C-terminal domain", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "AIF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029325": {"description": "ITPR-interacting domain", "go_ids": ["GO:0005102"], "go_terms": ["GO:0005102:signaling receptor binding:F"], "name": "ITPR-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029326": {"description": "Sperm-specific antigen 2, C-terminal", "go_ids": [], "go_terms": [], "name": "SSFA2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029327": {"description": "HAUS augmin-like complex subunit 4", "go_ids": ["GO:0070652", "GO:0051225"], "go_terms": ["GO:0070652:HAUS complex:C", "GO:0051225:spindle assembly:P"], "name": "HAUS4", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR029328": {"description": "Spindle pole component Bbp1, N-terminal", "go_ids": [], "go_terms": [], "name": "Bbp1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029329": {"description": "Domain of unknown function DUF4472", "go_ids": [], "go_terms": [], "name": "DUF4472", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029330": {"description": "Spindle pole body component Bbp1, C-terminal", "go_ids": [], "go_terms": [], "name": "Bbp1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029331": {"description": "Muscular LMNA-interacting protein", "go_ids": [], "go_terms": [], "name": "MLIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029332": {"description": "PEHE domain", "go_ids": [], "go_terms": [], "name": "PEHE_dom", "pathway_ids": ["R-MMU-3214847", "R-DME-3214847", "R-HSA-9772755", "R-HSA-3214847", "R-MMU-9772755", "R-DRE-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DRE-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR029333": {"description": "BBS2, GAE domain", "go_ids": [], "go_terms": [], "name": "BBS2_GAE_dom", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922", "R-DRE-5620922", "R-RNO-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR029334": {"description": "Protein phosphatase 1 binding domain", "go_ids": [], "go_terms": [], "name": "PP1-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029335": {"description": "Phage-encoded virulence factor", "go_ids": [], "go_terms": [], "name": "PAGK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029336": {"description": "Protein of unknown function DUF4594", "go_ids": [], "go_terms": [], "name": "DUF4594", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029337": {"description": "Inhibitory synaptic factor 2", "go_ids": [], "go_terms": [], "name": "INSYN2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029338": {"description": "Tumour suppressing sub-chromosomal transferable candidate 4", "go_ids": [], "go_terms": [], "name": "TSSC4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029339": {"description": "Protein FAM219", "go_ids": [], "go_terms": [], "name": "FAM219", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029340": {"description": "Protein FAM222", "go_ids": [], "go_terms": [], "name": "FAM222", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029341": {"description": "FAM21/CAPZIP domain", "go_ids": [], "go_terms": [], "name": "FAM21/CAPZIP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029342": {"description": "ECSIT, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ECIST_C", "pathway_ids": ["R-MMU-975871", "R-HSA-975871", "R-HSA-166058", "R-HSA-975138", "R-MMU-166058", "R-MMU-6799198", "R-RNO-166058", "R-HSA-6799198", "R-DME-6799198", "R-XTR-6799198", "R-BTA-975871", "R-RNO-6799198", "R-RNO-975871", "R-BTA-166058", "R-XTR-975138", "R-DRE-6799198", "R-MMU-975138", "R-RNO-975138", "R-BTA-6799198", "R-BTA-975138", "R-XTR-166058", "R-XTR-975871"], "pathways": ["R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-6799198:r:Complex I biogenesis", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-XTR-6799198:r:Complex I biogenesis", "R-BTA-975871:r:MyD88 cascade initiated on plasma membrane", "R-RNO-6799198:r:Complex I biogenesis", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-BTA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-XTR-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-XTR-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-XTR-975871:r:MyD88 cascade initiated on plasma membrane"], "type": "Domain"}, "IPR029343": {"description": "Coiled-coil domain-containing protein 14", "go_ids": [], "go_terms": [], "name": "CCDC14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029344": {"description": "Histone RNA hairpin-binding protein, RNA-binding domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "SLBP_RNA_bind", "pathway_ids": ["R-DME-159230", "R-HSA-159230", "R-CEL-159230", "R-MMU-77588", "R-HSA-77588", "R-MMU-73856", "R-HSA-73856", "R-DME-77588", "R-DME-73856", "R-CEL-73856", "R-CEL-77588", "R-MMU-159230"], "pathways": ["R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA"], "type": "Domain"}, "IPR029345": {"description": "Maltose transport system permease protein MalF, P2 domain", "go_ids": [], "go_terms": [], "name": "MalF_P2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029346": {"description": "Ubiquitin carboxyl-terminal hydrolase, C-terminal", "go_ids": [], "go_terms": [], "name": "USP_C", "pathway_ids": ["R-RNO-6781823", "R-CEL-8948747", "R-DME-6804757", "R-HSA-6781827", "R-MMU-6782135", "R-BTA-5689880", "R-DME-6781823", "R-HSA-5689880", "R-RNO-8866652", "R-MMU-8866652", "R-HSA-6781823", "R-DME-8866652", "R-MMU-5689880", "R-MMU-6781823", "R-HSA-8866652", "R-HSA-6804757", "R-DME-8948747", "R-HSA-6782210", "R-SCE-6782210", "R-XTR-5689880", "R-DME-6782135", "R-RNO-8948747", "R-RNO-6782210", "R-HSA-8948747", "R-HSA-390471", "R-RNO-6782135", "R-MMU-6804757", "R-MMU-8948747", "R-HSA-6782135", "R-CEL-6782210", "R-RNO-5689880", "R-CEL-6781823", "R-CEL-5689880", "R-RNO-6804757", "R-SPO-6782210", "R-CEL-6782135", "R-MMU-6782210", "R-DME-6782210", "R-SPO-6782135", "R-HSA-5689603", "R-HSA-2173788", "R-DME-5689880", "R-SCE-6782135"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-8948747:r:Regulation of PTEN localization", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DME-8948747:r:Regulation of PTEN localization", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-XTR-5689880:r:Ub-specific processing proteases", "R-DME-6782135:r:Dual incision in TC-NER", "R-RNO-8948747:r:Regulation of PTEN localization", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-5689880:r:Ub-specific processing proteases", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-5689603:r:UCH proteinases", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Domain"}, "IPR029347": {"description": "Raptor, N-terminal CASPase-like domain", "go_ids": [], "go_terms": [], "name": "Raptor_N", "pathway_ids": ["R-DDI-9639288", "R-DDI-5628897", "R-DDI-1632852", "R-DDI-165159", "R-SCE-9639288", "R-MMU-380972", "R-MMU-165159", "R-SPO-3371571", "R-MMU-1632852", "R-DDI-166208", "R-MMU-9639288", "R-SPO-9639288", "R-MMU-3371571", "R-DDI-380972", "R-DDI-3371571", "R-HSA-9639288", "R-HSA-5628897", "R-MMU-8943724", "R-DDI-8943724", "R-HSA-166208", "R-HSA-8943724", "R-MMU-166208", "R-MMU-5628897", "R-HSA-1632852", "R-HSA-165159", "R-HSA-3371571", "R-HSA-9920951", "R-SCE-3371571", "R-HSA-380972"], "pathways": ["R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-1632852:r:Macroautophagy", "R-DDI-165159:r:MTOR signalling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-165159:r:MTOR signalling", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-MMU-1632852:r:Macroautophagy", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-HSA-166208:r:mTORC1-mediated signalling", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-166208:r:mTORC1-mediated signalling", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1632852:r:Macroautophagy", "R-HSA-165159:r:MTOR signalling", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK"], "type": "Domain"}, "IPR029348": {"description": "Nucleotidyltransferase-like domain", "go_ids": [], "go_terms": [], "name": "NTF-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029349": {"description": "Domain of unknown function DUF4443", "go_ids": [], "go_terms": [], "name": "DUF4443", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029351": {"description": "GAD domain", "go_ids": [], "go_terms": [], "name": "GAD_dom", "pathway_ids": ["R-HSA-379726"], "pathways": ["R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Domain"}, "IPR029352": {"description": "Photoreceptor cilium actin regulator", "go_ids": [], "go_terms": [], "name": "PCARE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029353": {"description": "Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NYAP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029354": {"description": "Cylicin, N-terminal", "go_ids": [], "go_terms": [], "name": "Cylicin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029355": {"description": "Proline-rich protein 19", "go_ids": [], "go_terms": [], "name": "Pro-rich_19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029356": {"description": "Family of FAM53", "go_ids": [], "go_terms": [], "name": "FAM53", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029357": {"description": "Spermatogenesis-associated protein 7", "go_ids": [], "go_terms": [], "name": "SPATA7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029358": {"description": "Cilia-and flagella-associated protein 96", "go_ids": [], "go_terms": [], "name": "CFAP96", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029359": {"description": "FAM181", "go_ids": [], "go_terms": [], "name": "FAM181", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029360": {"description": "Serine/arginine repetitive matrix protein, C-terminal", "go_ids": [], "go_terms": [], "name": "SRRM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029361": {"description": "Sperm microtubule inner protein 9", "go_ids": [], "go_terms": [], "name": "SPMIP9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029362": {"description": "Fusion protein IQCJ-SCHIP1, N-terminal", "go_ids": [], "go_terms": [], "name": "IQCJ-SCHIP1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029363": {"description": "Protein of unknown function DUF4575", "go_ids": [], "go_terms": [], "name": "DUF4575", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029364": {"description": "ALK and LTK ligand 1/2", "go_ids": ["GO:0030971", "GO:0030298"], "go_terms": ["GO:0030971:receptor tyrosine kinase binding:F", "GO:0030298:receptor signaling protein tyrosine kinase activator activity:F"], "name": "ALKL1/2", "pathway_ids": ["R-RNO-201556", "R-MMU-201556", "R-RNO-9842663", "R-HSA-201556", "R-DRE-9842663", "R-HSA-9842663", "R-DRE-201556", "R-MMU-9842663"], "pathways": ["R-RNO-201556:r:Signaling by ALK", "R-MMU-201556:r:Signaling by ALK", "R-RNO-9842663:r:Signaling by LTK", "R-HSA-201556:r:Signaling by ALK", "R-DRE-9842663:r:Signaling by LTK", "R-HSA-9842663:r:Signaling by LTK", "R-DRE-201556:r:Signaling by ALK", "R-MMU-9842663:r:Signaling by LTK"], "type": "Family"}, "IPR029365": {"description": "TMEM238 protein", "go_ids": [], "go_terms": [], "name": "TMEM238", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029366": {"description": "TMEM206 protein", "go_ids": [], "go_terms": [], "name": "TMEM206", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029367": {"description": "Small integral membrane protein 10", "go_ids": [], "go_terms": [], "name": "SMIM10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029368": {"description": "Small integral membrane protein 19", "go_ids": [], "go_terms": [], "name": "SMIM19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029369": {"description": "Domain of unknown function with conserved HDNR motif", "go_ids": [], "go_terms": [], "name": "HDNR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029370": {"description": "TMEM117 protein", "go_ids": [], "go_terms": [], "name": "TMEM117", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029371": {"description": "TMEM101 protein", "go_ids": [], "go_terms": [], "name": "TMEM101", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029372": {"description": "Voltage-dependent calcium channel gamma-like subunit", "go_ids": ["GO:0005262", "GO:0005244", "GO:0016020"], "go_terms": ["GO:0005262:calcium channel activity:F", "GO:0005244:voltage-gated monoatomic ion channel activity:F", "GO:0016020:membrane:C"], "name": "Tmem37", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029373": {"description": "FAM216", "go_ids": [], "go_terms": [], "name": "FAM216", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029374": {"description": "TMEM156 protein", "go_ids": [], "go_terms": [], "name": "TMEM156", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029375": {"description": "Cilia- and flagella-associated protein 141", "go_ids": [], "go_terms": [], "name": "CFAP141", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029376": {"description": "Domain of unknown function DUF4549", "go_ids": [], "go_terms": [], "name": "DUF4549", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029377": {"description": "TMEM220 protein", "go_ids": [], "go_terms": [], "name": "TMEM220", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029378": {"description": "Type III secreted effector HopW1-1/HolPsyAE", "go_ids": ["GO:0044419"], "go_terms": ["GO:0044419:biological process involved in interspecies interaction between organisms:P"], "name": "T3SS_HopW1-1/HolPsyAE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029379": {"description": "FAM163", "go_ids": [], "go_terms": [], "name": "FAM163", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029380": {"description": "FAM124", "go_ids": [], "go_terms": [], "name": "FAM124", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029381": {"description": "Cancer-associated gene protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "CAGE1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029382": {"description": "Glycosylated lysosomal membrane protein", "go_ids": [], "go_terms": [], "name": "GLMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029383": {"description": "ADP-ribosylation factor-like protein 6-interacting protein 6", "go_ids": [], "go_terms": [], "name": "ARL6IP6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029384": {"description": "Speriolin, C-terminal", "go_ids": [], "go_terms": [], "name": "Speriolin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029385": {"description": "Speriolin, N-terminal", "go_ids": [], "go_terms": [], "name": "Speriolin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029386": {"description": "TMEM169 protein", "go_ids": [], "go_terms": [], "name": "TMEM169", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029387": {"description": "Organic solute transporter subunit beta", "go_ids": ["GO:0015721", "GO:0005886", "GO:0046982", "GO:0022857"], "go_terms": ["GO:0015721:bile acid and bile salt transport:P", "GO:0005886:plasma membrane:C", "GO:0046982:protein heterodimerization activity:F", "GO:0022857:transmembrane transporter activity:F"], "name": "OSTbeta", "pathway_ids": ["R-HSA-159418", "R-BTA-159418", "R-MMU-159418"], "pathways": ["R-HSA-159418:r:Recycling of bile acids and salts", "R-BTA-159418:r:Recycling of bile acids and salts", "R-MMU-159418:r:Recycling of bile acids and salts"], "type": "Family"}, "IPR029388": {"description": "Domain of unknown function DUF4650", "go_ids": [], "go_terms": [], "name": "DUF4650", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029389": {"description": "Izumo sperm-egg fusion protein", "go_ids": [], "go_terms": [], "name": "IZUMO", "pathway_ids": ["R-MMU-1300645", "R-RNO-1300645", "R-HSA-1300645", "R-DRE-1300645", "R-BTA-1300645"], "pathways": ["R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-DRE-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-BTA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding"], "type": "Domain"}, "IPR029390": {"description": "AP-3 complex subunit beta, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AP3B_C", "pathway_ids": ["R-BTA-432722", "R-HSA-6802952", "R-MMU-432722", "R-HSA-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR029391": {"description": "COP9 signalosome complex, subunit 9, metazoa", "go_ids": [], "go_terms": [], "name": "CSN9_metazoa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029392": {"description": "AP-5 complex subunit sigma-1", "go_ids": ["GO:0030119", "GO:0016197", "GO:0000724"], "go_terms": ["GO:0030119:AP-type membrane coat adaptor complex:C", "GO:0016197:endosomal transport:P", "GO:0000724:double-strand break repair via homologous recombination:P"], "name": "AP-5_subunit_s1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029393": {"description": "Tumour suppressor candidate 2", "go_ids": [], "go_terms": [], "name": "FUS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029394": {"description": "AP-3 complex subunit beta 1, serine-rich domain", "go_ids": [], "go_terms": [], "name": "AP3B1_Ser", "pathway_ids": ["R-BTA-432722", "R-HSA-6802952", "R-MMU-432722", "R-HSA-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR029395": {"description": "Protein of unknown function DUF4514", "go_ids": [], "go_terms": [], "name": "DUF4514", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029396": {"description": "Tuberoinfundibular peptide of 39 residues", "go_ids": ["GO:0007218", "GO:0005576"], "go_terms": ["GO:0007218:neuropeptide signaling pathway:P", "GO:0005576:extracellular region:C"], "name": "TIP39", "pathway_ids": ["R-DRE-373080", "R-HSA-418555", "R-RNO-373080", "R-HSA-373080", "R-MMU-373080", "R-MMU-418555"], "pathways": ["R-DRE-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Family"}, "IPR029397": {"description": "Tube, Death domain", "go_ids": [], "go_terms": [], "name": "Tube_Death", "pathway_ids": ["R-DME-214842", "R-DME-214874", "R-DME-214844", "R-DME-214863", "R-DME-209442", "R-DME-214869", "R-DME-214862"], "pathways": ["R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"], "type": "Domain"}, "IPR029398": {"description": "DNA polymerase beta, thumb domain", "go_ids": [], "go_terms": [], "name": "PolB_thumb", "pathway_ids": ["R-HSA-5651801", "R-BTA-110362", "R-RNO-5693571", "R-RNO-5689880", "R-RNO-5649702", "R-MMU-110373", "R-HSA-5693571", "R-RNO-73930", "R-HSA-110381", "R-MMU-73930", "R-RNO-5651801", "R-DRE-5651801", "R-DRE-73930", "R-HSA-73930", "R-RNO-110373", "R-BTA-5649702", "R-BTA-110373", "R-MMU-5649702", "R-MMU-5693571", "R-BTA-5689880", "R-DRE-110381", "R-HSA-5689880", "R-DRE-5649702", "R-SCE-110362", "R-RNO-110362", "R-DRE-110373", "R-MMU-110381", "R-HSA-5649702", "R-DRE-110362", "R-RNO-110381", "R-MMU-5689880", "R-MMU-110362", "R-BTA-5651801", "R-BTA-73930", "R-HSA-110373", "R-DRE-5689880", "R-MMU-5651801", "R-HSA-110362", "R-BTA-110381"], "pathways": ["R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-BTA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DRE-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-SCE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway"], "type": "Domain"}, "IPR029399": {"description": "TMEM192 family", "go_ids": [], "go_terms": [], "name": "TMEM192", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029400": {"description": "TERF1-interacting nuclear factor 2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TINF2_N", "pathway_ids": ["R-MMU-174430", "R-HSA-171306", "R-MMU-110330", "R-HSA-174414", "R-MMU-2559586", "R-MMU-174417", "R-HSA-174430", "R-HSA-110328", "R-HSA-1221632", "R-HSA-174411", "R-MMU-110331", "R-HSA-171319", "R-MMU-9670095", "R-MMU-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110331:r:Cleavage of the damaged purine", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Domain"}, "IPR029401": {"description": "Nudix hydrolase, N-terminal", "go_ids": [], "go_terms": [], "name": "Nudix_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029402": {"description": "tRNA-guanine transglycosylase, patch-forming domain C2", "go_ids": [], "go_terms": [], "name": "TGT_C2", "pathway_ids": ["PWY-6711", "PWY-7923"], "pathways": ["PWY-6711:t:archaeosine biosynthesis I", "PWY-7923:t:archaeosine biosynthesis II"], "type": "Domain"}, "IPR029403": {"description": "RESP18 domain", "go_ids": [], "go_terms": [], "name": "RESP18_dom", "pathway_ids": ["R-HSA-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR029404": {"description": "CDAN1-interacting nuclease 1", "go_ids": [], "go_terms": [], "name": "CDIN1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029405": {"description": "APCDD1 domain", "go_ids": [], "go_terms": [], "name": "APCDD1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029406": {"description": "Ewing's tumour-associated antigen 1", "go_ids": [], "go_terms": [], "name": "ETAA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029407": {"description": "Kidney-associated antigen 1", "go_ids": [], "go_terms": [], "name": "KAAG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029409": {"description": "Transmembrane protein 237", "go_ids": [], "go_terms": [], "name": "TMEM237", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029410": {"description": "CAP-associated domain", "go_ids": [], "go_terms": [], "name": "CAP_assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029411": {"description": "Rhamnogalacturonan lyase, domain III", "go_ids": [], "go_terms": [], "name": "RG-lyase_III", "pathway_ids": ["PWY-6771"], "pathways": ["PWY-6771:t:rhamnogalacturonan type I degradation II (bacteria)"], "type": "Domain"}, "IPR029412": {"description": "Centrosomal protein of 19kDa", "go_ids": [], "go_terms": [], "name": "CEP19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029413": {"description": "Rhamnogalacturonan lyase, domain II", "go_ids": [], "go_terms": [], "name": "RG-lyase_II", "pathway_ids": ["PWY-6771"], "pathways": ["PWY-6771:t:rhamnogalacturonan type I degradation II (bacteria)"], "type": "Domain"}, "IPR029414": {"description": "Tricorn protease, PDZ domain", "go_ids": [], "go_terms": [], "name": "Tricorn_PDZ", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR029415": {"description": "Protein Lines, C-terminal", "go_ids": [], "go_terms": [], "name": "Lines_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029416": {"description": "Cilia- and flagella-associated protein 300", "go_ids": [], "go_terms": [], "name": "CFAP300", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029417": {"description": "FAM227 Protein", "go_ids": [], "go_terms": [], "name": "FAM227", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029418": {"description": "MDN2-binding protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MTBP_C", "pathway_ids": ["R-MMU-9766229", "R-HSA-9766229", "R-XTR-9766229"], "pathways": ["R-MMU-9766229:r:Degradation of CDH1", "R-HSA-9766229:r:Degradation of CDH1", "R-XTR-9766229:r:Degradation of CDH1"], "type": "Domain"}, "IPR029419": {"description": "Argininosuccinate lyase, C-terminal", "go_ids": [], "go_terms": [], "name": "Arg_succ_lyase_C", "pathway_ids": ["PWY-7400", "PWY-4984", "PWY-5", "PWY-4983", "PWY-5154", "R-BTA-70635", "R-MMU-70635", "R-HSA-70635", "R-SPO-70635", "R-GGA-187630", "R-SCE-70635", "R-RNO-70635", "R-HSA-9956529"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-4984:t:urea cycle", "PWY-5:t:canavanine biosynthesis", "PWY-4983:t:nitric oxide biosynthesis II (mammals)", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-BTA-70635:r:Urea cycle", "R-MMU-70635:r:Urea cycle", "R-HSA-70635:r:Urea cycle", "R-SPO-70635:r:Urea cycle", "R-GGA-187630:r:Arginine metabolism", "R-SCE-70635:r:Urea cycle", "R-RNO-70635:r:Urea cycle", "R-HSA-9956529:r:ASL variants cause argininosuccinate aciduria"], "type": "Domain"}, "IPR029420": {"description": "MDM2-binding protein, central domain", "go_ids": [], "go_terms": [], "name": "MTBP_central", "pathway_ids": ["R-MMU-9766229", "R-HSA-9766229", "R-XTR-9766229"], "pathways": ["R-MMU-9766229:r:Degradation of CDH1", "R-HSA-9766229:r:Degradation of CDH1", "R-XTR-9766229:r:Degradation of CDH1"], "type": "Domain"}, "IPR029421": {"description": "MDM2-binding protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MTBP_N", "pathway_ids": ["R-MMU-9766229", "R-HSA-9766229", "R-XTR-9766229"], "pathways": ["R-MMU-9766229:r:Degradation of CDH1", "R-HSA-9766229:r:Degradation of CDH1", "R-XTR-9766229:r:Degradation of CDH1"], "type": "Domain"}, "IPR029422": {"description": "Coiled coil protein 74, C-terminal", "go_ids": [], "go_terms": [], "name": "CCDC74_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029423": {"description": "LRRC37A/B like protein 1, C-terminal", "go_ids": [], "go_terms": [], "name": "LRRC37AB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029424": {"description": "MMS22-like, C-terminal", "go_ids": [], "go_terms": [], "name": "MMS22L_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029425": {"description": "Protein MMS22-like, N-terminal", "go_ids": [], "go_terms": [], "name": "MMS22L_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029426": {"description": "FAM86, N-terminal", "go_ids": [], "go_terms": [], "name": "FAM86_N", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-BTA-8876725", "R-HSA-8876725", "R-MMU-8876725"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-BTA-8876725:r:Protein methylation", "R-HSA-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation"], "type": "Domain"}, "IPR029427": {"description": "Altered inheritance of mitochondria protein 23, mitochondrial", "go_ids": [], "go_terms": [], "name": "AIM23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029428": {"description": "Mapk-regulated corepressor-interacting protein", "go_ids": [], "go_terms": [], "name": "MCRIP", "pathway_ids": ["R-HSA-9764725"], "pathways": ["R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription"], "type": "Family"}, "IPR029429": {"description": "Ciliary BBSome complex subunit 2, middle region", "go_ids": [], "go_terms": [], "name": "BBS2_Mid", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922", "R-DRE-5620922", "R-RNO-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR029430": {"description": "Ciliary BBSome complex subunit 2, N-terminal", "go_ids": [], "go_terms": [], "name": "BBS2_N", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922", "R-DRE-5620922", "R-RNO-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR029431": {"description": "Tumour protein p53-inducible nuclear protein", "go_ids": [], "go_terms": [], "name": "TP53INP", "pathway_ids": ["R-MMU-6804756", "R-HSA-6803204", "R-HSA-6804756"], "pathways": ["R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation"], "type": "Family"}, "IPR029432": {"description": "Gp28/Gp37-like domain", "go_ids": [], "go_terms": [], "name": "Gp28/Gp37-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029433": {"description": "DUF4438, N-terminal", "go_ids": [], "go_terms": [], "name": "DUF4438_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029434": {"description": "Putative transcriptional regulator", "go_ids": [], "go_terms": [], "name": "Put_trans_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029435": {"description": "Protein TOPAZ1 domain", "go_ids": [], "go_terms": [], "name": "TOPAZ1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029436": {"description": "Eukaryotic glycogen debranching enzyme, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AGL_euk_N", "pathway_ids": ["PWY-7238", "PWY-6724", "PWY-5941", "PWY-6737", "R-SCE-70221", "R-HSA-6798695", "R-HSA-70221", "R-SCE-6798695"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6724:t:starch degradation II", "PWY-5941:t:glycogen degradation II", 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["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR029446": {"description": "Coatomer beta subunit, appendage platform domain", "go_ids": [], "go_terms": [], "name": "COPB1_appendage_platform_dom", "pathway_ids": ["R-SPO-6807878", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-SCE-6807878", "R-RNO-6811434", "R-SCE-6811434", "R-RNO-6807878", "R-DME-6798695", "R-SCE-6798695", "R-HSA-6807878", "R-BTA-6798695", "R-MMU-6807878", "R-DDI-6811434", "R-GGA-6798695", "R-MMU-6811434", "R-DME-6811434", "R-BTA-6807878", "R-HSA-6811434", "R-DDI-6807878", "R-DRE-6811434", "R-DRE-6798695", "R-DRE-6807878", "R-SPO-6811434", "R-MMU-6798695", "R-DME-6807878", "R-BTA-6811434", "R-RNO-6798695", "R-GGA-6811434", "R-GGA-6807878"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6798695:r:Neutrophil degranulation", 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"R-MMU-6783310"], "pathways": ["R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-DME-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR029450": {"description": "Apoptosis regulator M11", "go_ids": [], "go_terms": [], "name": "Apo_reg_M11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029451": {"description": "Rapamycin-insensitive companion of mTOR, middle domain", "go_ids": [], "go_terms": [], "name": "RICTOR_M", "pathway_ids": ["R-MMU-9856530", "R-DDI-1257604", "R-MMU-5218920", "R-HSA-5674400", "R-MMU-6804757", "R-SPO-389357", "R-SPO-1257604", "R-SPO-5218920", "R-MMU-1257604", "R-SCE-389357", "R-DDI-6804757", "R-SCE-9856530", "R-MMU-389357", "R-HSA-5218920", "R-DDI-9856530", "R-SCE-6804757", "R-HSA-6804757", "R-DDI-5218920", "R-DDI-389357", "R-SCE-1257604", "R-HSA-389357", "R-HSA-9920951", "R-HSA-9856530", "R-HSA-1257604", "R-SPO-6804757", "R-SPO-9856530", "R-SCE-5218920"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular 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mediated vascular permeability", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Domain"}, "IPR029453": {"description": "Rapamycin-insensitive companion of mTOR, domain 4", "go_ids": [], "go_terms": [], "name": "Rictor_IV", "pathway_ids": ["R-MMU-9856530", "R-DDI-1257604", "R-MMU-5218920", "R-HSA-5674400", "R-MMU-6804757", "R-SPO-389357", "R-SPO-1257604", "R-SPO-5218920", "R-MMU-1257604", "R-SCE-389357", "R-DDI-6804757", "R-SCE-9856530", "R-MMU-389357", "R-HSA-5218920", "R-DDI-9856530", "R-SCE-6804757", "R-HSA-6804757", "R-DDI-5218920", "R-DDI-389357", "R-SCE-1257604", "R-HSA-389357", "R-HSA-9920951", "R-HSA-9856530", "R-HSA-1257604", "R-SPO-6804757", "R-SPO-9856530", "R-SCE-5218920"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling 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"R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Domain"}, "IPR029454": {"description": "ODR-4-like", "go_ids": [], "go_terms": [], "name": "ODR-4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029455": {"description": "Hypothetical glycosyl hydrolase family 15", "go_ids": [], "go_terms": [], "name": "GHL15", 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"R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit"], "type": "Domain"}, "IPR029460": {"description": "DNA polymerase, helix-hairpin-helix motif", "go_ids": [], "go_terms": [], "name": "DNAPol_HHH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029461": {"description": "Metallophosphoesterase, TT1561-like", "go_ids": [], "go_terms": [], "name": "TT1561-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029462": {"description": "Regulator of nucleoside diphosphate kinase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Rnk_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029463": {"description": "Lysine-specific metallo-endopeptidase", "go_ids": ["GO:0004222"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F"], "name": "Lys_MEP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029464": {"description": "Type I restriction enzyme R protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HSDR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029465": {"description": "TupA-like ATPgrasp protein", "go_ids": [], "go_terms": [], "name": "ATPgrasp_TupA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029466": {"description": "No apical meristem-associated, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NAM-associated_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029467": {"description": "Cytochrome c7-like", "go_ids": [], "go_terms": [], "name": "Cyt_c7-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029468": {"description": "O-antigen polysaccharide polymerase Wzy", "go_ids": [], "go_terms": [], "name": 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"go_ids": [], "go_terms": [], "name": "DUF6807", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029476": {"description": "Deoxyribonuclease NucA/NucB", "go_ids": [], "go_terms": [], "name": "DNase_NucA_NucB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029477": {"description": "Diacylglycerol kinase type I, N-terminal", "go_ids": [], "go_terms": [], "name": "DAG_kinase_typeI_N", "pathway_ids": ["PWY-7039", "PWY-7817", "R-MMU-114508", "R-SSC-114508", "R-BTA-114508", "R-HSA-114508", "R-RNO-114508", "R-DME-114508", "R-CEL-114508"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-SSC-114508:r:Effects of PIP2 hydrolysis", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-CEL-114508:r:Effects of 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"name": "ABC_trans_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029482": {"description": "Putative peptidase domain, HRXXH", "go_ids": [], "go_terms": [], "name": "HRXXH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029483": {"description": "Glycosyl-hydrolase 97, C-terminal oligomerisation domain", "go_ids": [], "go_terms": [], "name": "GH97_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029485": {"description": "Cationic amino acid transporter, C-terminal", "go_ids": [], "go_terms": [], "name": "CAT_C", "pathway_ids": ["R-HSA-352230", "R-RNO-352230", "R-DRE-352230", "R-MMU-352230"], "pathways": ["R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-DRE-352230:r:Amino acid transport across the plasma membrane", "R-MMU-352230:r:Amino acid transport across the plasma membrane"], "type": "Domain"}, "IPR029486": {"description": "Glycosyl-hydrolase 97, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GH97_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029487": {"description": "Novel E3 ligase domain", "go_ids": ["GO:0016567", "GO:0004842"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0004842:ubiquitin-protein transferase activity:F"], "name": "NEL_dom", "pathway_ids": ["PWY-7511", "R-HSA-9956593"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense"], "type": "Domain"}, "IPR029488": {"description": "Hemingway/CFA97", "go_ids": [], "go_terms": [], "name": "Hmw/CFAP97", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029489": {"description": "O-GlcNAc transferase, C-terminal", "go_ids": [], "go_terms": [], "name": "OGT/SEC/SPY_C", "pathway_ids": ["PWY-7437", "R-HSA-5213460", "R-MMU-3214847", "R-RNO-5689603", "R-RNO-3214847", "R-HSA-9772755", "R-RNO-9772755", "R-HSA-5675482", "R-MMU-5675482", "R-RNO-5675482", "R-HSA-3214847", "R-HSA-5689603", "R-MMU-9772755", "R-MMU-5689603"], "pathways": ["PWY-7437:t:protein O-[N-acetyl]-glucosylation", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-3214847:r:HATs acetylate histones", "R-RNO-5689603:r:UCH proteinases", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5689603:r:UCH proteinases"], "type": "Domain"}, "IPR029490": {"description": "Cytochrome c-550 domain", "go_ids": [], "go_terms": [], "name": "Cytochrom_C550", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029491": {"description": "Helicase Helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "Helicase_HTH", "pathway_ids": ["R-HSA-5685942", "R-HSA-3108214", "R-HSA-5693616", "R-HSA-174414", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-174437", "R-HSA-9709570", "R-MMU-174414", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-MMU-174437", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR029492": {"description": "Domain of unknown function DUF4435", "go_ids": [], "go_terms": [], "name": "DUF4435", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029493": {"description": "ATP-dependent RecD2 DNA helicase-like, helix-hairpin-helix domain", "go_ids": [], "go_terms": [], "name": "RecD2-like_HHH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029494": {"description": "ssDNA thymidine ADP-ribosyltransferase, DarT", "go_ids": [], "go_terms": [], "name": "DarT", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis"], "type": "Domain"}, "IPR029495": {"description": "NACHT-associated domain", "go_ids": [], "go_terms": [], "name": "NACHT-assoc", "pathway_ids": ["PWY-7250", "R-HSA-5689901", "R-HSA-9705671", "R-HSA-9692916", "R-HSA-9707564", "R-MMU-5689901", "R-HSA-9660826", "R-RNO-5689901", "R-RNO-844456", "R-MMU-844456", "R-BTA-844456", "R-BTA-5689901", "R-HSA-844456"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5689901:r:Metalloprotease DUBs", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-BTA-844456:r:The NLRP3 inflammasome", "R-BTA-5689901:r:Metalloprotease DUBs", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Domain"}, "IPR029497": {"description": "Type 4 fimbrial biogenesis protein PilY2", "go_ids": [], "go_terms": [], "name": "Fimbrial_PilY2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029498": {"description": "Prion-inhibition and propagation, HeLo domain", "go_ids": [], "go_terms": [], "name": "HeLo_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029499": {"description": "Corrinoid adenosyltransferase, PduO-type", "go_ids": [], "go_terms": [], "name": "PduO-typ", "pathway_ids": ["R-HSA-9759218", "R-HSA-3359471", "R-MMU-9759218"], "pathways": ["R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-3359471:r:Defective MMAB causes MMA, cblB type", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism"], "type": "Family"}, "IPR029500": {"description": "NADPH-dependent 7-cyano-7-deazaguanine reductase QueF", "go_ids": ["GO:0008616"], "go_terms": ["GO:0008616:tRNA queuosine(34) biosynthetic process:P"], "name": "QueF", "pathway_ids": ["PWY-6700"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)"], "type": "Domain"}, "IPR029501": {"description": "Bacterial EndoU nuclease", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "EndoU_bac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029502": {"description": "Ribosomally synthesized peptide", "go_ids": [], "go_terms": [], "name": "Ribosomal_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029504": {"description": "Microcephalin, mammal", "go_ids": ["GO:0021987"], "go_terms": ["GO:0021987:cerebral cortex development:P"], "name": "Microcephalin_mammal", "pathway_ids": ["R-MMU-2299718", "R-HSA-2299718"], "pathways": ["R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-2299718:r:Condensation of Prophase Chromosomes"], "type": "Family"}, "IPR029512": {"description": "Coiled-coil domain-containing protein 154", "go_ids": [], "go_terms": [], "name": "CCDC154", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029515": {"description": "Liprin", "go_ids": [], "go_terms": [], "name": "Liprin", "pathway_ids": ["R-HSA-181430", "R-MMU-212676", "R-CEL-181430", "R-RNO-210500", "R-RNO-181430", "R-MMU-181430", "R-MMU-210500", "R-CEL-210500", "R-HSA-264642", "R-MMU-181429", "R-CEL-212676", "R-MMU-388844", "R-MMU-264642", "R-HSA-388844", "R-HSA-181429", "R-RNO-212676", "R-HSA-9725370", "R-RNO-264642", "R-CEL-388844", "R-RNO-388844", "R-CEL-181429", "R-RNO-181429", "R-CEL-264642", "R-HSA-212676", "R-HSA-210500"], "pathways": ["R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle"], "type": "Family"}, "IPR029519": {"description": "Nucleoredoxin-like protein 2", "go_ids": ["GO:0007600", "GO:0045494"], "go_terms": ["GO:0007600:sensory perception:P", "GO:0045494:photoreceptor cell maintenance:P"], "name": "RdCVF2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029520": {"description": "Nucleoredoxin-like protein 1", "go_ids": ["GO:0045494"], "go_terms": ["GO:0045494:photoreceptor cell maintenance:P"], "name": "RdCVF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029523": {"description": "INO80 complex, subunit Ies2", "go_ids": ["GO:0031011", "GO:0006338"], "go_terms": ["GO:0031011:Ino80 complex:C", "GO:0006338:chromatin remodeling:P"], "name": "INO80B/Ies2", "pathway_ids": ["R-HSA-5689603", "R-MMU-5696394", "R-MMU-5689603", "R-HSA-5696394"], "pathways": ["R-HSA-5689603:r:UCH proteinases", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Family"}, "IPR029525": {"description": "INO80 complex, subunit Ies6", "go_ids": ["GO:0031011", "GO:0006338"], "go_terms": ["GO:0031011:Ino80 complex:C", "GO:0006338:chromatin remodeling:P"], "name": "INO80C/Ies6", "pathway_ids": ["R-RNO-5689603", "R-HSA-5689603", "R-MMU-5696394", "R-MMU-5689603", "R-RNO-5696394", "R-HSA-5696394"], "pathways": ["R-RNO-5689603:r:UCH proteinases", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH proteinases", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Family"}, "IPR029526": {"description": "PiggyBac transposable element-derived protein", "go_ids": [], "go_terms": [], "name": "PGBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029562": {"description": "Retinoic acid receptor responder protein 2", "go_ids": ["GO:0005102", "GO:0006954", "GO:0050994"], "go_terms": ["GO:0005102:signaling receptor binding:F", "GO:0006954:inflammatory response:P", "GO:0050994:regulation of lipid catabolic process:P"], "name": "Chemerin", "pathway_ids": ["R-HSA-114608", "R-BTA-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR029569": {"description": "Calcium homeostasis modulator family", "go_ids": [], "go_terms": [], "name": "CALHM", "pathway_ids": ["R-HSA-9730628", "R-HSA-9717207"], "pathways": ["R-HSA-9730628:r:Sensory perception of salty taste", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste"], "type": "Family"}, "IPR029600": {"description": "Intraflagellar transport protein 81", "go_ids": ["GO:0060271", "GO:0015631", "GO:0042073", "GO:0030992"], "go_terms": ["GO:0060271:cilium assembly:P", "GO:0015631:tubulin binding:F", "GO:0042073:intraciliary transport:P", "GO:0030992:intraciliary transport particle B:C"], "name": "IFT81", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR029601": {"description": "Transient receptor potential cation channel subfamily M member 7, alpha-kinase domain", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "TRPM7_a-kinase_dom", "pathway_ids": ["R-MMU-3295583", "R-RNO-3295583", "R-HSA-3295583"], "pathways": ["R-MMU-3295583:r:TRP channels", "R-RNO-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Domain"}, "IPR029602": {"description": "Intraflagellar transport protein 74", "go_ids": ["GO:0060271", "GO:0048487", "GO:0042073", "GO:0030992"], "go_terms": ["GO:0060271:cilium assembly:P", "GO:0048487:beta-tubulin binding:F", "GO:0042073:intraciliary transport:P", "GO:0030992:intraciliary transport particle B:C"], "name": "IFT74", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR029614": {"description": "Chromatin remodeling regulator CECR2", "go_ids": ["GO:0090537", "GO:0006338"], "go_terms": ["GO:0090537:CERF complex:C", "GO:0006338:chromatin remodeling:P"], "name": "CECR2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029617": {"description": "Lid2 complex component Snt2", "go_ids": [], "go_terms": [], "name": "Snt2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029618": {"description": "Coiled-coil domain-containing protein 172", "go_ids": [], "go_terms": [], "name": "CCDC172", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029619": {"description": "Protein FAM81", "go_ids": [], "go_terms": [], "name": "FAM81", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029625": {"description": "Protein FAM169", "go_ids": [], "go_terms": [], "name": "FAM169", "pathway_ids": ["R-HSA-9035034", "R-MMU-9035034"], "pathways": ["R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle"], "type": "Family"}, "IPR029627": {"description": "Serine-rich coiled-coil domain-containing protein 1/2", "go_ids": [], "go_terms": [], "name": "CCSER1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029636": {"description": "Protein Csf1", "go_ids": ["GO:0016020", "GO:0006113"], "go_terms": ["GO:0016020:membrane:C", "GO:0006113:fermentation:P"], "name": "Csf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029638": {"description": "Protein FAM78", "go_ids": [], "go_terms": [], "name": "FAM78", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029641": {"description": "Anaphase-promoting complex subunit 16", "go_ids": ["GO:0016567", "GO:0005680"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0005680:anaphase-promoting complex:C"], "name": "APC16", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-HSA-2467813", "R-BTA-179409", "R-MMU-174154", "R-BTA-176412", "R-BTA-141430", "R-MMU-2467813", "R-MMU-179409", "R-MMU-69017", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-BTA-176409", "R-MMU-174048", "R-HSA-141430", "R-BTA-2467813", "R-BTA-174154", "R-BTA-174184", "R-HSA-174084", "R-HSA-176407", "R-BTA-174178", "R-BTA-176407", "R-HSA-176408", "R-BTA-68867", "R-MMU-174084", "R-HSA-68867", "R-HSA-176412", "R-HSA-176409", "R-MMU-176408", "R-MMU-176409", "R-MMU-68867", "R-BTA-174084", "R-HSA-9687136", "R-BTA-2559582", "R-BTA-174048", "R-MMU-2559582", "R-MMU-176412", "R-MMU-176407", "R-MMU-174184", "R-MMU-141430", "R-HSA-69017", "R-BTA-69017", "R-BTA-176408", "R-HSA-174048", "R-HSA-179409", "R-HSA-174154"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin"], "type": "Family"}, "IPR029656": {"description": "Arginine/serine-rich protein 1", "go_ids": [], "go_terms": [], "name": "RSRP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029659": {"description": "Proline-rich membrane anchor 1", "go_ids": [], "go_terms": [], "name": "PRIMA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029668": {"description": "Transmembrane protein 98", "go_ids": [], "go_terms": [], "name": "TMEM98", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029670": {"description": "UPF0524 family", "go_ids": [], "go_terms": [], "name": "UPF0524_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029672": {"description": "FAM199X family", "go_ids": [], "go_terms": [], "name": "FAM199X_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029673": {"description": "Transmembrane protein 179", "go_ids": [], "go_terms": [], "name": "TMEM179", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029675": {"description": "GPI-GalNAc transferase PGAP4", "go_ids": ["GO:0016757", "GO:0000139", "GO:0006506"], "go_terms": ["GO:0016757:glycosyltransferase activity:F", "GO:0000139:Golgi membrane:C", "GO:0006506:GPI anchor biosynthetic process:P"], "name": "PGAP4", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR029676": {"description": "Cilia- and flagella-associated protein 221", "go_ids": ["GO:0060271", "GO:0003341", "GO:0005929"], "go_terms": ["GO:0060271:cilium assembly:P", "GO:0003341:cilium movement:P", "GO:0005929:cilium:C"], "name": "CFAP221", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029681": {"description": "Coiled-coil domain-containing protein 157", "go_ids": [], "go_terms": [], "name": "CCDC157", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029684": {"description": "Schlafen family", "go_ids": [], "go_terms": [], "name": "Schlafen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029686": {"description": "Enhancer of split M4 family", "go_ids": ["GO:0007219", "GO:0007423"], "go_terms": ["GO:0007219:Notch signaling pathway:P", "GO:0007423:sensory organ development:P"], "name": "Malpha/m4/m2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029688": {"description": "Interactor of constitutive active ROPs", "go_ids": [], "go_terms": [], "name": "ICR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029691": {"description": "Prostate and testis expressed protein 2", "go_ids": [], "go_terms": [], "name": "PATE2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029695": {"description": "Transmembrane protein 74-like", "go_ids": [], "go_terms": [], "name": "TMEM74-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029703": {"description": "DNA polymerase epsilon catalytic subunit", "go_ids": ["GO:0008622", "GO:0003887", "GO:0006281", "GO:0006260", "GO:0003677"], "go_terms": ["GO:0008622:epsilon DNA polymerase complex:C", "GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0006281:DNA repair:P", "GO:0006260:DNA replication:P", "GO:0003677:DNA binding:F"], "name": "POL2", "pathway_ids": ["R-DDI-6782135", "R-DME-110314", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656169", "R-HSA-5696397", "R-DDI-6782210", "R-MMU-110314", "R-DDI-68952", "R-DME-68962", "R-DDI-68962", "R-HSA-68962", "R-HSA-6782210", "R-DME-68952", "R-HSA-5656169", "R-DME-6782135", "R-SCE-68952", "R-MMU-5696400", "R-SPO-5696397", "R-DME-5651801", "R-HSA-68952", "R-MMU-68962", "R-MMU-5651801", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-SCE-68962", "R-MMU-68952", "R-DME-5656169", "R-SPO-5696400", "R-SPO-68952", "R-DME-5696400", "R-SPO-6782210", "R-SPO-110314", "R-SPO-68962", "R-HSA-5696400", "R-HSA-110314", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-SCE-6782135", "R-SPO-5651801"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-68952:r:DNA replication initiation", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-68952:r:DNA replication initiation", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-68952:r:DNA replication initiation", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-MMU-68952:r:DNA replication initiation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-68952:r:DNA replication initiation", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR029704": {"description": "STEEP-like", "go_ids": [], "go_terms": [], "name": "STEEP-like", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-DME-72163", "R-XTR-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR029705": {"description": "VPS35 endosomal protein sorting factor-like", "go_ids": ["GO:0032456"], "go_terms": ["GO:0032456:endocytic recycling:P"], "name": "VPS35L", "pathway_ids": ["R-DDI-6798695", "R-MMU-6798695", "R-HSA-6798695", "R-DME-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR029708": {"description": "SERTA domain-containing protein 4", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "SERTAD4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029709": {"description": "Lipid droplet assembly factor 1", "go_ids": [], "go_terms": [], "name": "LDAF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029710": {"description": "DNA ligase 4", "go_ids": ["GO:0006281", "GO:0003910", "GO:0003677", "GO:0005524"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0003910:DNA ligase (ATP) activity:F", "GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F"], "name": "LIG4", "pathway_ids": ["R-HSA-5693571", "R-GGA-353423", "R-MMU-5693571", "R-DDI-5693571", "R-HSA-164843"], "pathways": ["R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Family"}, "IPR029711": {"description": "HAUS augmin-like complex subunit 7-like", "go_ids": [], "go_terms": [], "name": "Haus7-like", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR029713": {"description": "Transmembrane protein 168", "go_ids": [], "go_terms": [], "name": "TMEM168", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029715": {"description": "Shieldin complex subunit 2", "go_ids": [], "go_terms": [], "name": "FAM35A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029717": {"description": "FAM193 family", "go_ids": [], "go_terms": [], "name": "FAM193", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029723": {"description": "Integral membrane protein GPR137", "go_ids": [], "go_terms": [], "name": "GPR137", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029731": {"description": "OSGIN 1/2", "go_ids": [], "go_terms": [], "name": "OSGIN1/2", "pathway_ids": ["PWY-5882", "PWY-6526", "PWY-7045", "PWY-5871", "PWY-7626", "PWY-5856", "PWY-7989", "PWY-5421", "PWY-6495", "PWY-6340", "PWY-5855", "PWY-7689", "PWY-7677", "PWY-7151", "PWY-7412", "PWY-6378", "PWY-7010", "PWY-7692", "PWY-6379", "PWY-2467", "PWY-7615", "PWY-7757", "PWY-8049", "PWY-5857", "PWY-7624", "PWY-7659", "PWY-7565", "PWY-5318", "PWY-7150", "PWY-7667", "PWY-5706", "PWY-7983", "PWY-7604", "PWY-7212", "PWY-7895", "PWY-8100", "PWY-8374", "PWY-7629", "PWY-5873", "PWY-7230", "PWY-8432", "PWY-7733", "PWY-8012", "PWY-7984", "PWY-7009", "PWY-6831", "PWY-7861", "PWY-8038", "PWY-2724", "PWY-581", "PWY-8158", "PWY-7419", "PWY-6503", "PWY-7175", "PWY-7521", "PWY-7668", "PWY-7603", "PWY-7650", "PWY-8382", "PWY-7673", "PWY-7734", "PWY-7779", "PWY-7430", "PWY-7705", "PWY-5984", "PWY-5412", "PWY-7687", "PWY-8087", "PWY-321", "PWY-8036", "PWY-7660", "PWY-7407", "PWY-7599", "PWY-7988", "PWY-7698", "PWY-2421", "PWY-7513", "PWY-8111", "PWY-5434", "PWY-6552", "PWY-7826", "PWY-7937", "PWY-5870", "PWY-7638", "PWY-5413", "PWY-8035", "PWY-5414", "PWY-7949", "PWY-7749", "PWY-1381", "PWY-7085", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-7304", "PWY-7492", "PWY-6978", "PWY-5422", "PWY-6708", "PWY-5846", "PWY-7405", "PWY-6710", "PWY-7011", "PWY-7481", "PWY-5872", "PWY-7648", "PWY-7637", "PWY-601", "PWY-761", "PWY-7775", "PWY-7708", "PWY-6971", "PWY-8085", "PWY-7780", "PWY-7703"], "pathways": ["PWY-5882:t:epoxypseudoisoeugenol-2-methylbutanoate biosynthesis", "PWY-6526:t:limonene degradation III (to perillate)", "PWY-7045:t:mithramycin biosynthesis", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-7626:t:bacilysin biosynthesis", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-5421:t:dehydroabietic acid biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-6340:t:5,5'-dehydrodivanillate degradation", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7010:t:2-propylphenol degradation", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-2467:t:(+)-pisatin biosynthesis", "PWY-7615:t:pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)", "PWY-7757:t:bisphenol A degradation", "PWY-8049:t:pederin biosynthesis", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-7624:t:nystatin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin 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FR-33289 antibiotics biosynthesis", "PWY-6503:t:superpathway of ergotamine biosynthesis", "PWY-7175:t:nostoxanthin biosynthesis", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation", "PWY-7668:t:apicidin F biosynthesis", "PWY-7603:t:stephacidin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-7705:t:quinolinone B biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-5412:t:levopimaric acid biosynthesis", "PWY-7687:t:stipitatate biosynthesis", "PWY-8087:t:indole-3-acetate degradation II", "PWY-321:t:cutin biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7698:t:2,5-xylenol and 3,5-xylenol degradation", "PWY-2421:t:indole-3-acetate degradation I", "PWY-7513:t:flaviolin dimer and mompain biosynthesis", "PWY-8111:t:carbaryl degradation", "PWY-5434:t:(3E)-4,8-dimethylnona-1,3,7-triene biosynthesis I", "PWY-6552:t:caffeine degradation I (main, plants)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7937:t:fungal bioluminescence", "PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-7638:t:echinenone and zeaxanthin biosynthesis (Synechocystis)", "PWY-5413:t:neoabietic acid biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5414:t:palustric acid biosynthesis", "PWY-7949:t:diadinoxanthin and diatoxanthin interconversion", "PWY-7749:t:(-)-4'-demethyl-epipodophyllotoxin biosynthesis", "PWY-1381:t:fluorene degradation II", "PWY-7085:t:triethylamine degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-7304:t:3-amino-4,7-dihydroxy-coumarin biosynthesis", "PWY-7492:t:paspaline biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-5422:t:isopimaric acid biosynthesis", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5846:t:colchicine biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6710:t:poly-hydroxy fatty acids biosynthesis", "PWY-7011:t:2-isopropylphenol degradation", "PWY-7481:t:oryzalide A biosynthesis", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-7637:t:2,2'-dihydroxyketocarotenoids biosynthesis", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7775:t:propane degradation II", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-7780:t:butane degradation", "PWY-7703:t:2,4-xylenol degradation to protocatechuate"], "type": "Family"}, "IPR029751": {"description": "Large ribosomal subunit protein bL25, L25 domain", "go_ids": ["GO:0005840", "GO:0003735", "GO:0006412"], "go_terms": ["GO:0005840:ribosome:C", "GO:0003735:structural constituent of ribosome:F", "GO:0006412:translation:P"], "name": "Ribosomal_L25_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR029756": {"description": "MTH1187/YkoF-like", "go_ids": [], "go_terms": [], "name": "MTH1187/YkoF-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR029757": {"description": "DNA-directed RNA polymerase subunit delta", "go_ids": ["GO:0006351", "GO:0006355"], "go_terms": ["GO:0006351:DNA-templated transcription:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RpoE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029762": {"description": "Pyroglutamyl peptidase I, bacterial-type", "go_ids": ["GO:0008234", "GO:0016920", "GO:0005829", "GO:0006508"], "go_terms": ["GO:0008234:cysteine-type peptidase activity:F", "GO:0016920:pyroglutamyl-peptidase activity:F", "GO:0005829:cytosol:C", "GO:0006508:proteolysis:P"], "name": "PGP-I_bact-type", "pathway_ids": ["PWY-7942"], "pathways": ["PWY-7942:t:5-oxo-L-proline metabolism"], "type": "Family"}, "IPR029765": {"description": "Diphosphomevalonate decarboxylase", "go_ids": ["GO:0019287", "GO:0004163", "GO:0005829"], "go_terms": ["GO:0019287:isopentenyl diphosphate biosynthetic process, mevalonate pathway:P", "GO:0004163:diphosphomevalonate decarboxylase activity:F", "GO:0005829:cytosol:C"], "name": "Mev_diP_decarb", "pathway_ids": ["PWY-7391", "PWY-922", "R-SCE-9969896", "R-DRE-9969896", "R-MMU-9969896", "R-SPO-446199", "R-BTA-446199", "R-SCE-446199", "R-DDI-446199", "R-RNO-9969896", "R-DRE-446199", "R-BTA-9969896", "R-DDI-9969896", "R-RNO-446199", "R-MMU-446199", "R-HSA-446199", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-DRE-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-446199:r:Synthesis of dolichyl-phosphate", "R-DDI-446199:r:Synthesis of dolichyl-phosphate", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-RNO-446199:r:Synthesis of dolichyl-phosphate", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR029767": {"description": "UDP-N-acetylglucosamine 2-epimerase WecB-like", "go_ids": [], "go_terms": [], "name": "WecB-like", "pathway_ids": ["PWY-8462"], "pathways": ["PWY-8462:t:UDP-N-acetyl-alpha-D-mannosamine biosynthesis"], "type": "Family"}, "IPR029774": {"description": "Centriole, cilia and spindle-associated protein", "go_ids": ["GO:0005856"], "go_terms": ["GO:0005856:cytoskeleton:C"], "name": "CSAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029775": {"description": "NPH4", "go_ids": ["GO:0090090", "GO:0005856", "GO:0097730"], "go_terms": ["GO:0090090:negative regulation of canonical Wnt signaling pathway:P", "GO:0005856:cytoskeleton:C", "GO:0097730:non-motile cilium:C"], "name": "NPHP4", "pathway_ids": ["R-MMU-2028269", "R-HSA-2028269", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-2028269:r:Signaling by Hippo", "R-HSA-2028269:r:Signaling by Hippo", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR029776": {"description": 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"R-HSA-418555", "R-HSA-400042", "R-BTA-418597", "R-SPO-8980692", "R-SPO-9652282", "R-BTA-445355", "R-RNO-163615", "R-HSA-381676", "R-HSA-164378", "R-HSA-418597", "R-BTA-170660", "R-HSA-170670", "R-HSA-8935690", "R-HSA-9664323", "R-RNO-2514859", "R-PFA-936837", "R-HSA-9634597", "R-HSA-392154", "R-MMU-418597", "R-BTA-163615", "R-RNO-400042", "R-HSA-5578768", "R-RNO-445355", "R-DDI-170670", "R-HSA-5610787", "R-DME-163615", "R-MMU-2514859", "R-DDI-163615", "R-MMU-163615", "R-SPO-983168", "R-SPO-6803207", "R-MMU-400042", "R-HSA-163359", "R-HSA-9660821", "R-DME-418597", "R-RNO-170660", "R-DDI-5610787", "R-HSA-445355", "R-RNO-8935690", "R-DDI-2514859", "R-BTA-170670", "R-HSA-418594", "R-MMU-170660", "R-PFA-6798695", "R-SPO-199418", "R-MMU-170670", "R-HSA-9856530", "R-BTA-5610787", "R-HSA-163615", "R-RNO-170670"], "pathways": ["R-SPO-5223345:r:Miscellaneous transport and binding events", "R-RNO-418597:r:G alpha (z) signalling events", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-DME-170670:r:Adenylate cyclase inhibitory pathway", "R-DDI-170660:r:Adenylate cyclase activating pathway", "R-MMU-8935690:r:Digestion", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-SSC-8935690:r:Digestion", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-170660:r:Adenylate cyclase activating pathway", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-170660:r:Adenylate cyclase activating pathway", "R-HSA-8942233:r:Intestinal infectious diseases", "R-DME-5610787:r:Hedgehog 'off' state", "R-BTA-5578768:r:Physiological factors", "R-MMU-5578768:r:Physiological factors", "R-DDI-418597:r:G alpha (z) signalling events", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-5578768:r:Physiological factors", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-BTA-418597:r:G alpha (z) signalling events", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-BTA-445355:r:Smooth Muscle Contraction", "R-RNO-163615:r:PKA activation", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-164378:r:PKA activation in glucagon signalling", "R-HSA-418597:r:G alpha (z) signalling events", "R-BTA-170660:r:Adenylate cyclase activating pathway", "R-HSA-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-8935690:r:Digestion", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-PFA-936837:r:Ion transport by P-type ATPases", "R-HSA-9634597:r:GPER1 signaling", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-418597:r:G alpha (z) signalling events", "R-BTA-163615:r:PKA activation", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-5578768:r:Physiological factors", "R-RNO-445355:r:Smooth Muscle Contraction", "R-DDI-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-163615:r:PKA activation", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-163615:r:PKA activation", "R-MMU-163615:r:PKA activation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-DME-418597:r:G alpha (z) signalling events", "R-RNO-170660:r:Adenylate cyclase activating pathway", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-8935690:r:Digestion", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-170660:r:Adenylate cyclase activating pathway", "R-PFA-6798695:r:Neutrophil degranulation", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-163615:r:PKA activation", "R-RNO-170670:r:Adenylate cyclase inhibitory pathway"], "type": "Homologous_superfamily"}, "IPR029790": {"description": "EFG1/Phd1/StuA family", "go_ids": [], "go_terms": [], "name": "EFG1/Phd1/StuA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029827": {"description": "J domain-containing protein 1-like", "go_ids": [], "go_terms": [], "name": "JDP1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029841": {"description": "Cyclin-dependent kinase inhibitor 1", "go_ids": ["GO:0007346", "GO:0072331"], "go_terms": ["GO:0007346:regulation of mitotic cell cycle:P", "GO:0072331:signal transduction by p53 class mediator:P"], "name": "CDKN1A", "pathway_ids": ["R-HSA-69563", "R-HSA-187577", "R-MMU-187577", "R-MMU-198323", "R-HSA-8951664", "R-MMU-8852276", "R-HSA-69202", "R-HSA-2559582", "R-HSA-69231", "R-HSA-9617828", "R-HSA-2559586", "R-HSA-198323", "R-MMU-69202", "R-HSA-69656", "R-HSA-8941855", "R-MMU-6804116", "R-HSA-9616222", "R-HSA-8878166", "R-HSA-9825892", "R-HSA-9661069", "R-HSA-8866911", "R-HSA-5674400", "R-MMU-2559586", "R-HSA-8852276", "R-MMU-2559582", "R-HSA-9755511", "R-HSA-6804116", "R-HSA-69895", "R-HSA-6785807", "R-HSA-9703465", "R-MMU-69563", "R-MMU-69656", "R-MMU-9616222", "R-HSA-9725370", "R-HSA-9702518", "R-MMU-69231"], "pathways": ["R-HSA-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-8951664:r:Neddylation", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-MMU-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-MMU-69563:r:p53-Dependent G1 DNA Damage Response", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Family"}, "IPR029856": {"description": "Protein AMBP", "go_ids": [], "go_terms": [], "name": "AMBP", "pathway_ids": ["R-HSA-2168880", "R-MMU-2168880", "R-RNO-2168880"], "pathways": ["R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-RNO-2168880:r:Scavenging of heme from plasma"], "type": "Family"}, "IPR029861": {"description": "V-set and immunoglobulin domain-containing protein 1", "go_ids": ["GO:0030277", "GO:0005886", "GO:0003382"], "go_terms": ["GO:0030277:maintenance of gastrointestinal epithelium:P", "GO:0005886:plasma membrane:C", "GO:0003382:epithelial cell morphogenesis:P"], "name": "VSIG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029865": {"description": "Dyslexia-associated protein KIAA0319-like", "go_ids": [], "go_terms": [], "name": "KIAA0319-like", "pathway_ids": ["R-RNO-8856828", "R-MMU-8856828", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828"], "pathways": ["R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis"], "type": "Family"}, "IPR029866": {"description": "Steroidogenic acute regulatory protein", "go_ids": ["GO:0120020", "GO:0005739", "GO:0006694", "GO:0015485"], "go_terms": ["GO:0120020:cholesterol transfer activity:F", "GO:0005739:mitochondrion:C", "GO:0006694:steroid biosynthetic process:P", "GO:0015485:cholesterol binding:F"], "name": "StAR", "pathway_ids": ["R-DRE-9837999", "R-MMU-196108", "R-HSA-196108", "R-DRE-196108", "R-MMU-9837999", "R-BTA-196108", "R-BTA-9837999", "R-HSA-9837999", "R-RNO-9837999", "R-RNO-196108"], "pathways": ["R-DRE-9837999:r:Mitochondrial protein degradation", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-DRE-196108:r:Pregnenolone biosynthesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-196108:r:Pregnenolone biosynthesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-196108:r:Pregnenolone biosynthesis"], "type": "Family"}, "IPR029899": {"description": "Kinase non-catalytic C-lobe domain-containing protein 1", "go_ids": ["GO:0005085", "GO:0007264"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0007264:small GTPase-mediated signal transduction:P"], "name": "KNDC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029901": {"description": "Protein Spire", "go_ids": ["GO:0003779", "GO:0045010", "GO:0016192"], "go_terms": ["GO:0003779:actin binding:F", "GO:0045010:actin nucleation:P", "GO:0016192:vesicle-mediated transport:P"], "name": "Spire", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029903": {"description": "RmlD-like, substrate binding domain", "go_ids": [], "go_terms": [], "name": "RmlD-like-bd", "pathway_ids": ["R-MMU-5689880", "R-DRE-5689880", "R-BTA-5689880", "R-DRE-156581", "R-HSA-5689880", "R-RNO-156581", "R-HSA-156581", "R-MMU-156581", "R-DDI-6799198", "R-RNO-5689880", "R-XTR-156581"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DRE-156581:r:Methylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-156581:r:Methylation", "R-HSA-156581:r:Methylation", "R-MMU-156581:r:Methylation", "R-DDI-6799198:r:Complex I biogenesis", "R-RNO-5689880:r:Ub-specific processing proteases", "R-XTR-156581:r:Methylation"], "type": "Domain"}, "IPR029962": {"description": "Trichome birefringence-like family", "go_ids": ["GO:0016413"], "go_terms": ["GO:0016413:O-acetyltransferase activity:F"], "name": "TBL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR029978": {"description": "LIM domain only protein 7", "go_ids": ["GO:0023051", "GO:0030155"], "go_terms": ["GO:0023051:regulation of signaling:P", "GO:0030155:regulation of cell adhesion:P"], "name": "LMO-7", "pathway_ids": ["R-HSA-9725370", "R-HSA-8951664", "R-HSA-983168"], "pathways": ["R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR029982": {"description": "Kaptin", "go_ids": ["GO:0007015", "GO:0015629", "GO:0003779"], "go_terms": ["GO:0007015:actin filament organization:P", "GO:0015629:actin cytoskeleton:C", "GO:0003779:actin binding:F"], "name": "Kptn", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR029993": {"description": "Plant galacturonosyltransferase GAUT", "go_ids": ["GO:0047262"], "go_terms": ["GO:0047262:polygalacturonate 4-alpha-galacturonosyltransferase activity:F"], "name": "GAUT", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR030030": {"description": "Scaffold protein salvador", "go_ids": ["GO:0035329", "GO:0006915", "GO:0042127", "GO:0060090"], "go_terms": ["GO:0035329:hippo signaling:P", "GO:0006915:apoptotic process:P", "GO:0042127:regulation of cell population proliferation:P", "GO:0060090:molecular adaptor activity:F"], "name": "Sav", "pathway_ids": ["R-DME-390150", "R-DME-390098", "R-DME-390089", "R-MMU-2028269", "R-DME-2028269", "R-RNO-2028269", "R-HSA-2028269"], "pathways": ["R-DME-390150:r:DS ligand bound to FT receptor", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-DME-390089:r:Formation of the Hippo kinase cassette", "R-MMU-2028269:r:Signaling by Hippo", "R-DME-2028269:r:Signaling by Hippo", "R-RNO-2028269:r:Signaling by Hippo", "R-HSA-2028269:r:Signaling by Hippo"], "type": "Family"}, "IPR030031": {"description": "PDZ domain-containing protein MAGIX", "go_ids": [], "go_terms": [], "name": "MAGIX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030045": {"description": "Alpha-catulin 1", "go_ids": ["GO:0007266"], "go_terms": ["GO:0007266:Rho protein signal transduction:P"], "name": "CTNNAL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030048": {"description": "Survival protein SurE", "go_ids": ["GO:0008252"], "go_terms": ["GO:0008252:nucleotidase activity:F"], "name": "SurE", "pathway_ids": ["PWY-7821", "PWY-7185", "PWY-5381", "PWY-6596", "PWY-5695", "PWY-6607", "PWY-6608", "PWY-6606"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-5381:t:NAD salvage (plants)", "PWY-6596:t:adenosine nucleotides degradation I", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II"], "type": "Family"}, "IPR030072": {"description": "Xin actin-binding repeat-containing protein 1/2", "go_ids": ["GO:0003779", "GO:0030036"], "go_terms": ["GO:0003779:actin binding:F", "GO:0030036:actin cytoskeleton organization:P"], "name": "XIRP1/XIRP2", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Family"}, "IPR030113": {"description": "Actin-filament associated protein", "go_ids": [], "go_terms": [], "name": "AFAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030125": {"description": "SPIN90/Ldb17", "go_ids": [], "go_terms": [], "name": "SPIN90/Ldb17", "pathway_ids": ["R-HSA-5663213", "R-MMU-5663213", "R-HSA-2029482", "R-HSA-9664422", "R-MMU-2029482"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation"], "type": "Family"}, "IPR030127": {"description": "I-BAR domain containing protein MTSS1/MTSS2", "go_ids": ["GO:0003779"], "go_terms": ["GO:0003779:actin binding:F"], "name": "MTSS1/MTSS2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030159": {"description": "Autoinducer 2 ABC transporter, substrate-binding protein LsrB", "go_ids": ["GO:0043190"], "go_terms": ["GO:0043190:ATP-binding cassette (ABC) transporter complex:C"], "name": "LsrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030182": {"description": "Purine permease, plant", "go_ids": ["GO:0015211", "GO:0016020"], "go_terms": ["GO:0015211:purine nucleoside transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "PUP_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030183": {"description": "S-type anion channel", "go_ids": ["GO:0016020", "GO:0008308", "GO:0006873"], "go_terms": ["GO:0016020:membrane:C", "GO:0008308:voltage-gated monoatomic anion channel activity:F", "GO:0006873:intracellular monoatomic ion homeostasis:P"], "name": "SLAC/SLAH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030184": {"description": "WAT1-related protein", "go_ids": ["GO:0022857", "GO:0016020"], "go_terms": ["GO:0022857:transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "WAT1-related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030185": {"description": "Malic acid transport protein", "go_ids": ["GO:0016020", "GO:0015140", "GO:0071423"], "go_terms": ["GO:0016020:membrane:C", "GO:0015140:malate transmembrane transporter activity:F", "GO:0071423:malate transmembrane transport:P"], "name": "Mae1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030189": {"description": "Ureide permease, plant", "go_ids": ["GO:0016020", "GO:0071705", "GO:0022857"], "go_terms": ["GO:0016020:membrane:C", "GO:0071705:nitrogen compound transport:P", "GO:0022857:transmembrane transporter activity:F"], "name": "UPS_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030190": {"description": "Macrolide export protein MacA, alpha-hairpin domain superfamily", "go_ids": ["GO:1990195", "GO:1990961", "GO:0019898"], "go_terms": ["GO:1990195:macrolide transmembrane transporter complex:C", "GO:1990961:xenobiotic detoxification by transmembrane export across the plasma membrane:P", "GO:0019898:extrinsic component of membrane:C"], "name": "MacA_alpha-hairpin_sf", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638334", "R-HSA-9760173"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9760173:r:Secretion of toxins"], "type": "Homologous_superfamily"}, "IPR030191": {"description": "Cytosine permease", "go_ids": ["GO:0016020", "GO:0015209"], "go_terms": ["GO:0016020:membrane:C", "GO:0015209:cytosine transmembrane transporter activity:F"], "name": "CodB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030192": {"description": "Miniconductance mechanosensitive channel YbdG", "go_ids": ["GO:0071470", "GO:0016020", "GO:0008381"], "go_terms": ["GO:0071470:cellular response to osmotic stress:P", "GO:0016020:membrane:C", "GO:0008381:mechanosensitive monoatomic ion channel activity:F"], "name": "YbdG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030217": {"description": "Nuclear RNA export factor", "go_ids": [], "go_terms": [], "name": "NXF_fam", "pathway_ids": ["R-CEL-159231", "R-BTA-159230", "R-SPO-159236", "R-SPO-159227", "R-SPO-159231", "R-CEL-159227", "R-DME-159236", "R-DME-159231", "R-DME-159227", "R-RNO-159227", "R-BTA-159227", "R-MMU-159236", "R-MMU-159230", "R-DME-159230", "R-HSA-159230", "R-HSA-159231", "R-RNO-159230", "R-MMU-159227", "R-HSA-159227", "R-CEL-159230", "R-RNO-159231", "R-RNO-159236", "R-BTA-159236", "R-BTA-159231", "R-HSA-159236", "R-MMU-159231", "R-CEL-159236"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR030220": {"description": "Activated CDC42 kinase 1, UBA domain", "go_ids": ["GO:0007165", "GO:0004712", "GO:0016310"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0004712:protein serine/threonine/tyrosine kinase activity:F", "GO:0016310:phosphorylation:P"], "name": "Ack1_UBA_dom", "pathway_ids": ["R-RNO-9842663", "R-HSA-9842663", "R-MMU-9842663"], "pathways": ["R-RNO-9842663:r:Signaling by LTK", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-9842663:r:Signaling by LTK"], "type": "Domain"}, "IPR030224": {"description": "Sla2 family", "go_ids": ["GO:0030276", "GO:0006897"], "go_terms": ["GO:0030276:clathrin binding:F", "GO:0006897:endocytosis:P"], "name": "Sla2_fam", "pathway_ids": ["R-CEL-8856828", "R-MMU-8856828", "R-HSA-9700645", "R-HSA-8856828", "R-MMU-432722", "R-CEL-432722", "R-HSA-432722", "R-HSA-9725370"], "pathways": ["R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Family"}, "IPR030225": {"description": "Sterol regulatory element-binding protein cleavage-activating protein", "go_ids": ["GO:0032934", "GO:0032933", "GO:0005789", "GO:0000139"], "go_terms": ["GO:0032934:sterol binding:F", "GO:0032933:SREBP signaling pathway:P", "GO:0005789:endoplasmic reticulum membrane:C", "GO:0000139:Golgi membrane:C"], "name": "SCAP", "pathway_ids": ["R-HSA-1655829", "R-MMU-1655829", "R-HSA-9918432", "R-RNO-1655829"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9918432:r:Maturation of DENV proteins", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "type": "Family"}, "IPR030237": {"description": "Harmonin, N-terminal", "go_ids": [], "go_terms": [], "name": "Harmonin_N", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR030268": {"description": "Nesprin-4", "go_ids": ["GO:0034993", "GO:0005635"], "go_terms": ["GO:0034993:meiotic nuclear membrane microtubule tethering complex:C", "GO:0005635:nuclear envelope:C"], "name": "SYNE4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030312": {"description": "Interleukin-1 receptor-associated kinase 1-binding protein 1", "go_ids": ["GO:0043123", "GO:0006955"], "go_terms": ["GO:0043123:positive regulation of canonical NF-kappaB signal transduction:P", "GO:0006955:immune response:P"], "name": "IRAK1BP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030375": {"description": "Poxvirus cap-specific nucleoside 2-O-methyltransferase", "go_ids": ["GO:0004483", "GO:0003746", "GO:0006370", "GO:0031440"], "go_terms": ["GO:0004483:methyltransferase cap1 activity:F", "GO:0003746:translation elongation factor activity:F", "GO:0006370:7-methylguanosine mRNA capping:P", "GO:0031440:regulation of mRNA 3'-end processing:P"], "name": "Poxvir_cap_MeTfrase", "pathway_ids": ["PWY-7379"], "pathways": ["PWY-7379:t:mRNA capping II"], "type": "Family"}, "IPR030379": {"description": "Septin-type guanine nucleotide-binding (G) domain", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "G_SEPTIN_dom", "pathway_ids": ["R-RNO-111457", "R-SPO-111457", "R-HSA-111469", "R-HSA-111457", "R-HSA-5687128", "R-BTA-5620912", "R-MMU-111457", "R-SCE-111457", "R-HSA-5620912", "R-RNO-5620912", "R-SPO-111469", "R-RNO-5687128", "R-MMU-5687128", "R-RNO-111469", "R-MMU-5620912", "R-MMU-111469"], "pathways": ["R-RNO-111457:r:Release of apoptotic factors from the mitochondria", "R-SPO-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-SCE-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SPO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response"], "type": "Domain"}, "IPR030383": {"description": "Very large inducible GTPASE (VLIG)-type guanine nucleotide-binding (G) domain", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "G_VLIG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030389": {"description": "FeoB-type guanine nucleotide-binding (G) domain", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "G_FEOB_dom", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR030392": {"description": "Intramolecular chaperone auto-processing domain", "go_ids": [], "go_terms": [], "name": "S74_ICA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030395": {"description": "Glycerophosphodiester phosphodiesterase domain", "go_ids": ["GO:0006629", "GO:0008081"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0008081:phosphoric diester hydrolase activity:F"], "name": "GP_PDE_dom", "pathway_ids": ["R-RNO-6814848", "R-SCE-3295583", "R-HSA-6814848", "R-MMU-6814848", "R-SCE-204005", "R-BTA-6814848", "R-SCE-983168", "R-HSA-1483152", "R-HSA-1483115"], "pathways": ["R-RNO-6814848:r:Glycerophospholipid catabolism", "R-SCE-3295583:r:TRP channels", "R-HSA-6814848:r:Glycerophospholipid catabolism", "R-MMU-6814848:r:Glycerophospholipid catabolism", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-BTA-6814848:r:Glycerophospholipid catabolism", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1483152:r:Hydrolysis of LPE", "R-HSA-1483115:r:Hydrolysis of LPC"], "type": "Domain"}, "IPR030396": {"description": "Peptidase family S6 domain", "go_ids": ["GO:0004175"], "go_terms": ["GO:0004175:endopeptidase activity:F"], "name": "Peptidase_S6_dom", "pathway_ids": ["PWY-7884", "R-HSA-9760173", "R-HSA-9927020"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-9927020:r:Heme assimilation"], "type": "Domain"}, "IPR030417": {"description": "Membrane-spanning 4-domains subfamily A", "go_ids": [], "go_terms": [], "name": "MS4A", "pathway_ids": ["R-HSA-2871837", "R-HSA-2454202", "R-HSA-6798695", "R-RNO-2454202", "R-MMU-2871837", "R-MMU-2871809", "R-RNO-2730905", "R-HSA-2871796", "R-HSA-2871809", "R-MMU-2730905", "R-HSA-2730905", "R-MMU-6798695", "R-MMU-2454202", "R-RNO-2871809", "R-RNO-2871796", "R-RNO-2871837", "R-MMU-2871796"], "pathways": ["R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2871796:r:FCERI mediated MAPK activation"], "type": "Family"}, "IPR030429": {"description": "Sarcospan", "go_ids": ["GO:0016010", "GO:0005886"], "go_terms": ["GO:0016010:dystrophin-associated glycoprotein complex:C", "GO:0005886:plasma membrane:C"], "name": "Sarcospan", "pathway_ids": ["R-HSA-9913351", "R-MMU-9913351"], "pathways": ["R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Family"}, "IPR030431": {"description": "Endosomal transmembrane epsin interactor 1-3", "go_ids": [], "go_terms": [], "name": "ENTREP1-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030445": {"description": "Histone H3-K79 methyltransferase", "go_ids": ["GO:0051726", "GO:0031151"], "go_terms": ["GO:0051726:regulation of cell cycle:P", "GO:0031151:histone H3K79 methyltransferase activity:F"], "name": "H3-K79_meTrfase", "pathway_ids": ["R-CEL-3214841", "R-MMU-3214841", "R-HSA-3214841"], "pathways": ["R-CEL-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines"], "type": "Family"}, "IPR030465": {"description": "Centrosomal protein of 131kDa", "go_ids": ["GO:0035735"], "go_terms": ["GO:0035735:intraciliary transport involved in cilium assembly:P"], "name": "CEP131", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-DRE-380320", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR030474": {"description": "Interleukin-6/GCSF/MGF", "go_ids": ["GO:0005576", "GO:0006955", "GO:0005125"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006955:immune response:P", "GO:0005125:cytokine activity:F"], "name": "IL-6/GCSF/MGF", "pathway_ids": ["R-HSA-8853884", "R-HSA-449836", "R-HSA-1059683", "R-MMU-9674555", "R-HSA-9662834", "R-HSA-112411", "R-MMU-112411", "R-RNO-1059683", "R-HSA-2559582", "R-MMU-8957275", "R-BTA-8957275", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-RNO-110056", "R-SSC-449836", "R-BTA-1059683", "R-GGA-8957275", "R-SSC-9705462", "R-MMU-110056", "R-BTA-9674555", "R-GGA-449836", "R-HSA-6783783", "R-BTA-449836", "R-SSC-9674555", "R-HSA-381426", "R-HSA-9660821", "R-GGA-381426", "R-GGA-9674555", "R-BTA-9705462", "R-RNO-112411", "R-BTA-110056", "R-GGA-1059683", "R-HSA-6785807", "R-HSA-110056", "R-GGA-9705462", "R-MMU-9705462", "R-RNO-381426", "R-MMU-1059683", "R-HSA-9705462", "R-HSA-8957275", "R-HSA-9674555"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-SSC-449836:r:Other interleukin signaling", "R-BTA-1059683:r:Interleukin-6 signaling", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-BTA-9674555:r:Signaling by CSF3 (G-CSF)", "R-GGA-449836:r:Other interleukin signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-BTA-449836:r:Other interleukin signaling", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-9674555:r:Signaling by CSF3 (G-CSF)", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-BTA-110056:r:MAPK3 (ERK1) activation", "R-GGA-1059683:r:Interleukin-6 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)"], "type": "Family"}, "IPR030482": {"description": "p53 and DNA damage-regulated protein 1", "go_ids": [], "go_terms": [], "name": "PDRG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030511": {"description": "Tetratricopeptide repeat protein 26", "go_ids": [], "go_terms": [], "name": "TTC26", "pathway_ids": ["R-CEL-5620924", "R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR030523": {"description": "SH2B adapter protein", "go_ids": ["GO:0007165", "GO:0035591"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0035591:signaling adaptor activity:F"], "name": "SH2B", "pathway_ids": ["R-RNO-1170546", "R-MMU-1433559", "R-HSA-1433559", "R-MMU-1170546", "R-HSA-1170546", "R-RNO-983231", "R-HSA-983231", "R-MMU-982772", "R-MMU-9706369", "R-RNO-982772", "R-RNO-1433559", "R-MMU-983231", "R-HSA-2586552", "R-HSA-982772", "R-HSA-9706369"], "pathways": ["R-RNO-1170546:r:Prolactin receptor signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-982772:r:Growth hormone receptor signaling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-982772:r:Growth hormone receptor signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-9706369:r:Negative regulation of FLT3"], "type": "Family"}, "IPR030542": {"description": "Tandem C2 domains nuclear protein", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "Tac2-N", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030547": {"description": "DNA repair protein XRCC2", "go_ids": ["GO:0006281", "GO:0000724", "GO:0005657", "GO:0033063"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0000724:double-strand break repair via homologous recombination:P", "GO:0005657:replication fork:C", "GO:0033063:Rad51B-Rad51C-Rad51D-XRCC2 complex:C"], "name": "XRCC2", "pathway_ids": ["R-HSA-5685942", "R-HSA-9704331", "R-HSA-5693616", "R-HSA-9704646", "R-MMU-5693568", "R-HSA-5693554", "R-HSA-9709603", "R-MMU-5685942", "R-HSA-5693579", "R-MMU-5693616", "R-HSA-5693568", "R-MMU-5693579", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Family"}, "IPR030548": {"description": "DNA repair protein RAD51 homologue 2", "go_ids": ["GO:0033063", "GO:0000724", "GO:0006281", "GO:0003677"], "go_terms": ["GO:0033063:Rad51B-Rad51C-Rad51D-XRCC2 complex:C", "GO:0000724:double-strand break repair via homologous recombination:P", "GO:0006281:DNA repair:P", "GO:0003677:DNA binding:F"], "name": "RAD51B", "pathway_ids": ["R-HSA-5685942", "R-HSA-9704331", "R-HSA-5693616", "R-HSA-5693579", "R-HSA-9704646", "R-HSA-983231", "R-MMU-5693568", "R-HSA-5693554", "R-HSA-9709603", "R-MMU-5693579", "R-MMU-983231", "R-MMU-5693616", "R-HSA-5693568", "R-MMU-5685942", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Family"}, "IPR030559": {"description": "DNA polymerase zeta catalytic subunit", "go_ids": ["GO:0016035", "GO:0019985", "GO:0006281"], "go_terms": ["GO:0016035:zeta DNA polymerase complex:C", "GO:0019985:translesion synthesis:P", "GO:0006281:DNA repair:P"], "name": "PolZ_Rev3", "pathway_ids": ["R-MMU-5655862", "R-MMU-5656121", "R-SPO-5656121", "R-DME-110312", "R-DME-5655862", "R-HSA-110312", "R-SPO-5655862", "R-MMU-110312", "R-DME-5656121", "R-SPO-110312", "R-SCE-110312", "R-HSA-5656121", "R-HSA-5655862"], "pathways": ["R-MMU-5655862:r:Translesion synthesis by POLK", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-DME-110312:r:Translesion synthesis by REV1", "R-DME-5655862:r:Translesion synthesis by POLK", "R-HSA-110312:r:Translesion synthesis by REV1", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-MMU-110312:r:Translesion synthesis by REV1", "R-DME-5656121:r:Translesion synthesis by POLI", "R-SPO-110312:r:Translesion synthesis by REV1", "R-SCE-110312:r:Translesion synthesis by REV1", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-HSA-5655862:r:Translesion synthesis by POLK"], "type": "Family"}, "IPR030564": {"description": "Myotubularin", "go_ids": [], "go_terms": [], "name": "Myotubularin", "pathway_ids": ["R-SCE-1660516", "R-CEL-1660516", "R-BTA-1660499", "R-BTA-1660516", "R-HSA-1660517", "R-MMU-1660516", "R-DDI-1660499", "R-MMU-1632852", "R-SPO-1660499", "R-DRE-1660517", "R-HSA-1660499", "R-SPO-1660516", "R-MMU-1483248", "R-CEL-9035034", "R-RNO-1632852", "R-CEL-8876198", "R-SCE-1483248", "R-HSA-9035034", "R-SCE-1660517", "R-DDI-8876198", "R-DRE-1483248", "R-RNO-1660516", "R-HSA-1855183", "R-BTA-1660517", "R-DDI-1660517", "R-HSA-2173788", "R-BTA-1483248", "R-DDI-1483248", "R-MMU-9035034", "R-HSA-1483248", "R-DDI-1632852", "R-DDI-1660516", "R-SCE-1660499", "R-HSA-8876198", "R-HSA-1660516", "R-MMU-1660499", "R-CEL-1483248", "R-SCE-1632852", "R-RNO-1660517", "R-MMU-8876198", "R-RNO-1660499", "R-HSA-1632852", "R-CEL-1660499", "R-CEL-1660517", "R-SPO-1660517", "R-SPO-1483248", "R-MMU-2173788", "R-MMU-1660517", "R-DRE-1660516", "R-SPO-1632852", "R-DRE-1660499"], "pathways": ["R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1632852:r:Macroautophagy", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-9035034:r:RHOF GTPase cycle", "R-RNO-1632852:r:Macroautophagy", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-9035034:r:RHOF GTPase cycle", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-BTA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-1483248:r:Synthesis of PIPs at the ER membrane", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-DDI-1632852:r:Macroautophagy", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1483248:r:Synthesis of PIPs at the ER membrane", "R-SCE-1632852:r:Macroautophagy", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1632852:r:Macroautophagy", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DRE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SPO-1632852:r:Macroautophagy", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Family"}, "IPR030616": {"description": "Aurora kinase-like", "go_ids": ["GO:0004672"], "go_terms": ["GO:0004672:protein kinase activity:F"], "name": "Aur-like", "pathway_ids": ["R-SCE-75035", "R-DDI-8854050", "R-XTR-4615885", "R-HSA-174178", "R-HSA-9022692", "R-SSC-8854521", "R-MMU-2467813", "R-MMU-6804756", "R-XTR-2500257", "R-BTA-6804114", "R-MMU-68877", "R-RNO-6804114", "R-DRE-2467813", "R-HSA-8854518", "R-MMU-2565942", "R-DRE-141444", "R-XTR-141444", "R-RNO-8854521", "R-BTA-6804756", "R-BTA-2565942", "R-DDI-5673000", "R-HSA-8854050", "R-RNO-8854050", "R-SSC-2565942", "R-DME-4615885", "R-DRE-5663220", "R-DRE-6804756", "R-SSC-8854518", "R-MMU-141444", "R-HSA-141444", "R-HSA-8854521", "R-SCE-69473", "R-HSA-9648025", "R-SSC-6804114", "R-RNO-5663220", "R-CFA-8854050", "R-DME-6804756", "R-SCE-1632852", "R-HSA-6804756", "R-DDI-5674135", "R-HSA-6804114", "R-MMU-8854521", "R-MMU-8854518", "R-CFA-6804114", "R-RNO-2467813", "R-SPO-1632852", "R-MMU-5663220", "R-RNO-141444", "R-RNO-4615885", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-69601", "R-SCE-8854050", "R-XTR-2467813", "R-RNO-174178", "R-SSC-174178", "R-BTA-8854521", "R-MMU-174178", "R-MMU-4615885", "R-HSA-2565942", "R-CEL-8854050", "R-SCE-5693565", "R-CFA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-MMU-8854050", "R-RNO-6804756", "R-HSA-4615885", "R-MMU-9648025", "R-BTA-174178", "R-SSC-6804756", "R-DRE-174178", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-HSA-2500257", "R-RNO-8854518", "R-SPO-5628897", "R-DRE-2500257", "R-SSC-8854050", "R-SPO-380972", "R-XTR-5663220", "R-XTR-68877", "R-DDI-5675221", "R-BTA-8854050", "R-CFA-8854518", "R-CFA-8854521", "R-BTA-8854518", "R-XTR-174178", "R-SCE-380972", "R-DME-174178", "R-CFA-6804756", "R-RNO-9648025", "R-HSA-5663220", "R-CFA-174178", "R-XTR-6804756", "R-DDI-174178", "R-MMU-6804114", "R-SPO-8854050"], "pathways": ["R-SCE-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-SSC-8854521:r:Interaction between PHLDA1 and AURKA", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-8854521:r:Interaction between PHLDA1 and AURKA", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-5673000:r:RAF activation", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-8854521:r:Interaction between PHLDA1 and AURKA", "R-SCE-69473:r:G2/M DNA damage checkpoint", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CFA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-1632852:r:Macroautophagy", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-8854521:r:Interaction between PHLDA1 and AURKA", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-CFA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-SPO-1632852:r:Macroautophagy", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-8854521:r:Interaction between PHLDA1 and AURKA", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-68877:r:Mitotic Prometaphase", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CFA-8854518:r:AURKA Activation by TPX2", "R-CFA-8854521:r:Interaction between PHLDA1 and AURKA", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-XTR-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-CFA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-XTR-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "type": "Family"}, "IPR030634": {"description": "Synemin", "go_ids": ["GO:0005882", "GO:0045104", "GO:0005200", "GO:0008307"], "go_terms": ["GO:0005882:intermediate filament:C", "GO:0045104:intermediate filament cytoskeleton organization:P", "GO:0005200:structural constituent of cytoskeleton:F", "GO:0008307:structural constituent of muscle:F"], "name": "SYNM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030654": {"description": "Sugar 1,4-lactone oxidase", "go_ids": [], "go_terms": [], "name": "Sugar_lactone_oxidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030657": {"description": "Telomeric repeat-binding factor 2", "go_ids": ["GO:0000781", "GO:0042162", "GO:0000723", "GO:0005634", "GO:0031848"], "go_terms": ["GO:0000781:chromosome, telomeric region:C", "GO:0042162:telomeric repeat DNA binding:F", "GO:0000723:telomere maintenance:P", "GO:0005634:nucleus:C", "GO:0031848:protection from non-homologous end joining at telomere:P"], "name": "TERF2", "pathway_ids": ["R-MMU-174430", "R-MMU-110330", "R-HSA-171306", "R-HSA-174414", "R-MMU-2559586", "R-MMU-174417", "R-HSA-174430", "R-HSA-110328", "R-HSA-1221632", "R-HSA-174411", "R-MMU-110331", "R-MMU-9670095", "R-MMU-171319", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-MMU-174437", "R-HSA-110329", "R-GGA-418124", "R-HSA-110330", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-GGA-418124:r:Telomere maintenance", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Family"}, "IPR030658": {"description": "Macrophage colony-stimulating factor 1 receptor", "go_ids": ["GO:0019221", "GO:0004714", "GO:0019955"], "go_terms": ["GO:0019221:cytokine-mediated signaling pathway:P", "GO:0004714:transmembrane receptor protein tyrosine kinase activity:F", "GO:0019955:cytokine binding:F"], "name": "CSF-1_receptor", "pathway_ids": ["R-HSA-8853884", "R-HSA-449836", "R-DRE-449836", "R-RNO-449836", "R-HSA-9680350", "R-MMU-449836"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-449836:r:Other interleukin signaling", "R-DRE-449836:r:Other interleukin signaling", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-449836:r:Other interleukin signaling"], "type": "Family"}, "IPR030660": {"description": "High-affinity branched-chain amino acid transport ATP-binding protein", "go_ids": ["GO:0015803", "GO:0015658"], "go_terms": ["GO:0015803:branched-chain amino acid transport:P", "GO:0015658:branched-chain amino acid transmembrane transporter activity:F"], "name": "ABC_branched_ATPase_LivF/BraG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030661": {"description": "SUMO-activating enzyme subunit Uba2", "go_ids": ["GO:0016925", "GO:0019948"], "go_terms": ["GO:0016925:protein sumoylation:P", "GO:0019948:SUMO activating enzyme activity:F"], "name": "Uba2", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-DRE-3065676", "R-SPO-3065676", "R-DDI-3065678", "R-HSA-3065676", "R-MMU-3065676", "R-HSA-3065678", "R-DDI-3065676", "R-DRE-3065678", "R-SCE-3065676", "R-CEL-3065678", "R-CEL-3065676", "R-MMU-3065678", "R-SCE-3065678", "R-SPO-3065678"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid 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(UBE2I, UBC9)", "R-CEL-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-MMU-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SCE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SPO-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "type": "Family"}, "IPR030662": {"description": "Diphthine--ammonia ligase/Uncharacterised protein MJ0570", "go_ids": [], "go_terms": [], "name": "DPH6/MJ0570", "pathway_ids": ["PWY-7546", "PWY-6482", "R-SPO-5358493", "R-BTA-5358493", "R-SCE-5358493", "R-RNO-5358493", "R-HSA-5358493", "R-MMU-5358493"], "pathways": ["PWY-7546:t:diphthamide biosynthesis II (eukaryotes)", "PWY-6482:t:diphthamide biosynthesis I (archaea)", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Family"}, "IPR030664": {"description": "FAD-dependent oxidoreductase SdhA/FrdA/AprA", "go_ids": [], "go_terms": [], "name": "SdhA/FrdA/AprA", "pathway_ids": ["PWY-4302", "PWY-3781", "PWY-8086", "PWY-7254", "PWY-6728", "PWY-5913", "PWY-7384", "PWY-561", "PWY-7279", "PWY-5690", "PWY-5392", "PWY-6969", "R-HSA-9854311", "R-SPO-9854311", "R-DRE-9854311", "R-GGA-372987", "R-SSC-9854311", "R-DRE-71403", "R-HSA-611105", "R-RNO-9854311", "R-DME-9854311", "R-SSC-71403", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-CEL-9854311", "R-MMU-71403", "R-SCE-71403", "R-XTR-9854311", "R-DME-71403", "R-DDI-9854311", "R-DDI-71403", "R-RNO-71403", "R-XTR-71403", "R-HSA-71403", "R-SCE-9854311"], "pathways": ["PWY-4302:t:aerobic respiration III (alternative oxidase pathway)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-6728:t:methylaspartate cycle", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Family"}, "IPR030665": {"description": "Circadian clock protein kinase KaiC", "go_ids": [], "go_terms": [], "name": "KaiC", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Family"}, "IPR030666": {"description": "tRNA isopentenyltransferase, eukaryotes", "go_ids": ["GO:0052381", "GO:0008033", "GO:0005524"], "go_terms": ["GO:0052381:tRNA dimethylallyltransferase activity:F", "GO:0008033:tRNA processing:P", "GO:0005524:ATP binding:F"], "name": "IPP_transferase_euk", "pathway_ids": ["PWY-2781", "R-HSA-6782315", "R-HSA-6787450"], "pathways": ["PWY-2781:t:cis-zeatin biosynthesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Family"}, "IPR030667": {"description": "NEDD8-activating enzyme E1 regulatory subunit APP-BP1", "go_ids": ["GO:0019781", "GO:0045116"], "go_terms": ["GO:0019781:NEDD8 activating enzyme activity:F", "GO:0045116:protein neddylation:P"], "name": "APP-BP1", "pathway_ids": ["R-HSA-8951664"], "pathways": ["R-HSA-8951664:r:Neddylation"], "type": "Family"}, "IPR030668": {"description": "Spermidine/spermine synthase, eukaryotes", "go_ids": ["GO:0006595"], "go_terms": ["GO:0006595:polyamine metabolic process:P"], "name": "Spermi_synthase_euk", "pathway_ids": ["R-SPO-351202", "R-MMU-351202", "R-SCE-351202", "R-HSA-351202", "R-DDI-351202"], "pathways": ["R-SPO-351202:r:Metabolism of polyamines", "R-MMU-351202:r:Metabolism of polyamines", "R-SCE-351202:r:Metabolism of polyamines", "R-HSA-351202:r:Metabolism of polyamines", "R-DDI-351202:r:Metabolism of polyamines"], "type": "Family"}, "IPR030669": {"description": "Molybdenum storage protein subunit alpha/beta", "go_ids": ["GO:0030151", "GO:0005737"], "go_terms": ["GO:0030151:molybdenum ion binding:F", "GO:0005737:cytoplasm:C"], "name": "MoSto_subunit_alpha/beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030670": {"description": "Large ribosomal subunit protein uL10, eukaryota", "go_ids": ["GO:0042254"], "go_terms": ["GO:0042254:ribosome biogenesis:P"], "name": "uL10_euk", "pathway_ids": ["R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-DRE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-MMU-6791226", "R-RNO-975957", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-DRE-9954714", "R-SCE-975956", "R-CEL-1799339", "R-HSA-8950505", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-DRE-1799339", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-CEL-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-72689", "R-SCE-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-975956", "R-DRE-975956", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-HSA-975957", "R-DME-9954714", "R-DRE-72689", "R-DRE-9954716", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool 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"R-HSA-192823:r:Viral mRNA Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR030671": {"description": "Protein transport Sec61-beta/Sbh", "go_ids": ["GO:0005784", "GO:0006886"], "go_terms": ["GO:0005784:Sec61 translocon complex:C", "GO:0006886:intracellular protein transport:P"], "name": "Sec61-beta/Sbh", "pathway_ids": ["R-HSA-1799339", "R-HSA-1236974", "R-MMU-9609523", "R-SCE-9609523", "R-HSA-9609523", "R-DDI-9609523", "R-SPO-9609523", "R-CFA-9609523"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CFA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Family"}, "IPR030672": {"description": "Adenylate cyclase", "go_ids": ["GO:0004016", "GO:0006171", "GO:0005886"], "go_terms": ["GO:0004016:adenylate cyclase activity:F", "GO:0006171:cAMP biosynthetic process:P", "GO:0005886:plasma membrane:C"], "name": "Adcy", "pathway_ids": ["R-HSA-9634597", "R-RNO-418597", "R-HSA-381753", "R-DME-170670", "R-MMU-418597", "R-RNO-5610787", "R-BTA-163615", "R-RNO-400042", "R-HSA-163615", "R-HSA-432040", "R-DME-170660", "R-HSA-5610787", "R-HSA-442720", "R-MMU-5610787", "R-HSA-170660", "R-DME-163615", "R-MMU-163615", "R-DME-5610787", "R-MMU-400042", "R-HSA-163359", "R-HSA-9660821", "R-DME-418597", "R-RNO-170660", "R-HSA-418555", "R-HSA-400042", "R-BTA-418597", "R-BTA-170670", "R-RNO-163615", "R-HSA-418594", "R-HSA-381676", "R-MMU-170660", "R-HSA-164378", "R-HSA-418597", "R-BTA-170660", "R-HSA-170670", "R-MMU-170670", "R-HSA-9856530", "R-BTA-5610787", "R-HSA-9664323", "R-RNO-170670"], "pathways": ["R-HSA-9634597:r:GPER1 signaling", "R-RNO-418597:r:G alpha (z) signalling events", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-DME-170670:r:Adenylate cyclase inhibitory pathway", "R-MMU-418597:r:G alpha (z) signalling events", "R-RNO-5610787:r:Hedgehog 'off' state", "R-BTA-163615:r:PKA activation", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-163615:r:PKA activation", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-170660:r:Adenylate cyclase activating pathway", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-170660:r:Adenylate cyclase activating pathway", "R-DME-163615:r:PKA activation", "R-MMU-163615:r:PKA activation", "R-DME-5610787:r:Hedgehog 'off' state", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-DME-418597:r:G alpha (z) signalling events", "R-RNO-170660:r:Adenylate cyclase activating pathway", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-BTA-418597:r:G alpha (z) signalling events", "R-BTA-170670:r:Adenylate cyclase inhibitory pathway", "R-RNO-163615:r:PKA activation", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-170660:r:Adenylate cyclase activating pathway", "R-HSA-164378:r:PKA activation in glucagon signalling", "R-HSA-418597:r:G alpha (z) signalling events", "R-BTA-170660:r:Adenylate cyclase activating pathway", "R-HSA-170670:r:Adenylate cyclase inhibitory pathway", "R-MMU-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-170670:r:Adenylate cyclase inhibitory pathway"], "type": "Family"}, "IPR030673": {"description": "Pyrophosphatase, GppA/Ppx-type", "go_ids": [], "go_terms": [], "name": "PyroPPase_GppA_Ppx", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030674": {"description": "Nudix hydrolase, AtNUDT22-type", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Nudix_hydrolase_AtNUDT22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030675": {"description": "Lipid binding protein BPI/LBP", "go_ids": ["GO:0008289", "GO:0005576"], "go_terms": ["GO:0008289:lipid binding:F", "GO:0005576:extracellular region:C"], "name": "BPI/LBP", "pathway_ids": ["R-RNO-5686938", "R-HSA-6798695", "R-RNO-6803157", "R-BTA-6803157", "R-HSA-8964058", "R-MMU-166016", "R-HSA-166016", "R-BTA-6798695", "R-HSA-6785807", "R-MMU-5686938", "R-MMU-166020", "R-BTA-166016", "R-HSA-381426", "R-HSA-166020", "R-HSA-6803157", "R-MMU-6798695", "R-HSA-8957275", "R-MMU-6803157", "R-HSA-5686938", "R-RNO-166016", "R-HSA-9029569", "R-MMU-8964058", "R-RNO-166020", "R-RNO-6798695"], "pathways": ["R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-6803157:r:Antimicrobial peptides", "R-HSA-8964058:r:HDL remodeling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-166020:r:Transfer of LPS from LBP carrier to CD14", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-166020:r:Transfer of LPS from LBP carrier to CD14", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-8964058:r:HDL remodeling", "R-RNO-166020:r:Transfer of LPS from LBP carrier to CD14", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR030676": {"description": "Citrate carrier CitT-related", "go_ids": [], "go_terms": [], "name": "CitT-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030677": {"description": "Bifunctional NAD(P)H-hydrate repair enzyme Nnr", "go_ids": ["GO:0052855"], "go_terms": ["GO:0052855:ADP-dependent NAD(P)H-hydrate dehydratase activity:F"], "name": "Nnr", "pathway_ids": ["PWY-6938", "PWY-8137", "PWY-8136"], "pathways": ["PWY-6938:t:NADH repair (eukaryotes)", "PWY-8137:t:NADPH repair (eukaryotes)", "PWY-8136:t:NADPH repair (prokaryotes)"], "type": "Family"}, "IPR030678": {"description": "Peptide/nickel binding protein, MppA-type", "go_ids": ["GO:0055085", "GO:0043190"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0043190:ATP-binding cassette (ABC) transporter complex:C"], "name": "Peptide/Ni-bd", "pathway_ids": ["R-HSA-9927020", "R-HSA-1222538"], "pathways": ["R-HSA-9927020:r:Heme assimilation", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Family"}, "IPR030679": {"description": "ABC-type amino acid transport system, ATPase component, HisP-type", "go_ids": ["GO:0015424", "GO:0003333"], "go_terms": ["GO:0015424:ABC-type amino acid transporter activity:F", "GO:0003333:amino acid transmembrane transport:P"], "name": "ABC_ATPase_HisP-typ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030680": {"description": "Bombyxin A", "go_ids": [], "go_terms": [], "name": "Bombyxin_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030681": {"description": "Cholesterol 7-alpha-monooxygenase", "go_ids": ["GO:0008123", "GO:0006707", "GO:0006699", "GO:0071333", "GO:0042632", "GO:0004497", "GO:0016705"], "go_terms": ["GO:0008123:cholesterol 7-alpha-monooxygenase activity:F", "GO:0006707:cholesterol catabolic process:P", "GO:0006699:bile acid biosynthetic process:P", "GO:0071333:cellular response to glucose stimulus:P", "GO:0042632:cholesterol homeostasis:P", "GO:0004497:monooxygenase activity:F", "GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F"], "name": "Cholesterol_7a_monooxygenase", "pathway_ids": ["PWY-6061", "R-RNO-192105", "R-SSC-193807", "R-HSA-1989781", "R-RNO-193807", "R-SSC-193368", "R-MMU-193368", "R-MMU-211976", "R-RNO-211976", "R-RNO-193368", "R-MMU-192105", "R-HSA-193807", "R-HSA-193368", "R-HSA-192105", "R-SSC-192105", "R-HSA-211976", "R-SSC-211976", "R-MMU-193807"], "pathways": ["PWY-6061:t:bile acid biosynthesis, neutral pathway", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-SSC-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-SSC-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-211976:r:Endogenous sterols", "R-RNO-211976:r:Endogenous sterols", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-SSC-192105:r:Synthesis of bile acids and bile salts", "R-HSA-211976:r:Endogenous sterols", "R-SSC-211976:r:Endogenous sterols", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "type": "Family"}, "IPR030682": {"description": "Protein phosphatase 1 regulatory subunit 3B", "go_ids": ["GO:0019888", "GO:0005981", "GO:0000164"], "go_terms": ["GO:0019888:protein phosphatase regulator activity:F", "GO:0005981:regulation of glycogen catabolic process:P", "GO:0000164:protein phosphatase type 1 complex:C"], "name": "PP1_3B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030683": {"description": "Protein phosphatase 1 regulatory subunit 3C", "go_ids": [], "go_terms": [], "name": "PP1_3C", "pathway_ids": ["R-HSA-3785653", "R-BTA-3322077", "R-MMU-3322077", "R-DRE-3322077", "R-RNO-3322077", "R-HSA-3322077"], "pathways": ["R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-3322077:r:Glycogen 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"R-BTA-6803157:r:Antimicrobial peptides", "R-HSA-6799990:r:Metal sequestration by antimicrobial proteins", "R-BTA-6799990:r:Metal sequestration by antimicrobial proteins", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6799990:r:Metal sequestration by antimicrobial proteins", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-6803157:r:Antimicrobial peptides", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-1222449:r:Mtb iron assimilation by chelation"], "type": "Family"}, "IPR030685": {"description": "Serotransferrin, mammalian", "go_ids": ["GO:0008199", "GO:0006879", "GO:0006826", "GO:0005576"], "go_terms": ["GO:0008199:ferric iron binding:F", "GO:0006879:intracellular iron ion homeostasis:P", "GO:0006826:iron ion transport:P", "GO:0005576:extracellular region:C"], "name": "Serotransferrin_mammal", "pathway_ids": ["R-MMU-8856828", "R-RNO-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-RNO-917937", "R-MMU-8957275", "R-RNO-114608", "R-RNO-381426", "R-HSA-114608", "R-MMU-917937", "R-HSA-8856825", "R-RNO-8957275", "R-HSA-917937", "R-MMU-917977", "R-MMU-381426", "R-HSA-8957275", "R-RNO-8856828", "R-HSA-917977", "R-RNO-917977", "R-HSA-381426", "R-MMU-114608"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-917937:r:Iron uptake and transport", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-114608:r:Platelet degranulation", "R-MMU-917937:r:Iron uptake and transport", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-917937:r:Iron uptake and transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR030686": {"description": "Cytochrome P450 8B1", "go_ids": ["GO:0004497", "GO:0005506", "GO:0016705", "GO:0020037"], "go_terms": ["GO:0004497:monooxygenase activity:F", "GO:0005506:iron ion binding:F", "GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F", 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"GO:0045275", "GO:0009055"], "go_terms": ["GO:0008121:quinol-cytochrome-c reductase activity:F", "GO:0045275:respiratory chain complex III:C", "GO:0009055:electron transfer activity:F"], "name": "Cytochrome_b", "pathway_ids": ["R-HSA-9865881", "R-HSA-5419276", "R-DDI-611105", "R-DRE-611105", "R-DRE-9865881", "R-DME-611105", "R-MMU-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-RNO-5419276", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-BTA-9865881", "R-RNO-9865881", "R-SPO-611105", "R-DRE-5419276", "R-SCE-611105", "R-BTA-611105", "R-DME-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DDI-611105:r:Respiratory electron transport", "R-DRE-611105:r:Respiratory electron transport", "R-DRE-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory 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metabolism small protein", "go_ids": [], "go_terms": [], "name": "Small_EgtBD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030811": {"description": "Quinoprotein relay system zinc metallohydrolase 1", "go_ids": [], "go_terms": [], "name": "SoxH-rel_PQQ_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030812": {"description": "Hercynine metabolism protein, putative", "go_ids": [], "go_terms": [], "name": "EgtBD_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030814": {"description": "Small integral membrane protein", "go_ids": [], "go_terms": [], "name": "Mollicut_2TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030815": {"description": "Selenouridine synthase, SelU C-terminal-like subunit", "go_ids": [], "go_terms": [], "name": "Arch_SelU_Cterm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030816": {"description": "Conserved hypothetical protein CHP04376", "go_ids": [], "go_terms": [], "name": "CHP04376", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030817": {"description": "3,5/4-Trihydroxycyclohexa-1,2-dione hydrolase", "go_ids": ["GO:0019310", "GO:0016823", "GO:0030976"], "go_terms": ["GO:0019310:inositol catabolic process:P", "GO:0016823:hydrolase activity, acting on carbon-carbon bonds, in ketonic substances:F", "GO:0030976:thiamine pyrophosphate binding:F"], "name": "Myo_inos_IolD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030818": {"description": "Selenouridine synthase, SelU N-terminal-like subunit", "go_ids": [], "go_terms": [], "name": "Arch_SelU_Nterm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030819": {"description": "Outer membrane exchange protein TraA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Myxo_TraA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030820": {"description": "Outer membrane beta-barrel protein, proteobacteria", "go_ids": [], "go_terms": [], "name": "OMP_myx_plus_Proteobacteria", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030821": {"description": "Synergist-CTERM sorting domain", "go_ids": [], "go_terms": [], "name": "Synergist_CTERM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030822": {"description": "MXAN_4361/MXAN_4362 family small protein", "go_ids": [], "go_terms": [], "name": "MXAN_4361/MXAN_4362", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030823": {"description": "IolE/MocC family", "go_ids": [], "go_terms": [], "name": "IolE/MocC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030824": {"description": "Uncharacterised protein family CHP04562", "go_ids": [], "go_terms": [], "name": "CHP04562", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030825": {"description": "Integral membrane protein", "go_ids": [], "go_terms": [], "name": "Integral_membrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030826": {"description": "Small ribosomal subunit protein bTHX/bTHXc/bTHXm", "go_ids": ["GO:0005840"], "go_terms": ["GO:0005840:ribosome:C"], "name": "Ribosomal_bTHX/bTHXc/bTHXm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030827": {"description": "Inositol 2-dehydrogenase", "go_ids": [], "go_terms": [], "name": "Myo_inos_IolG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030828": {"description": "TyrR-like, helix-turn-helix domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "HTH_TyrR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030829": {"description": "Quinoprotein relay system zinc metallohydrolase 2", "go_ids": [], "go_terms": [], "name": "SoxH-rel_PQQ_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030830": {"description": "5-Dehydro-2-deoxygluconokinase", "go_ids": [], "go_terms": [], "name": "Myo_inos_IolC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030831": {"description": "Quinoprotein dehydrogenase-associated SoxYZ-like carrier", "go_ids": [], "go_terms": [], "name": "Fuse-rel_SoxYZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030832": {"description": "Processed acidic surface protein", "go_ids": [], "go_terms": [], "name": "Acidic_LPXTA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030834": {"description": "Polyketide synthase-associated domain", "go_ids": [], "go_terms": [], "name": "PKS_assoc_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030835": {"description": "Sulfite dehydrogenase SoxC", "go_ids": [], "go_terms": [], "name": "Sulfite_DH_SoxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030836": {"description": "Putative ABC transporter periplasmic binding protein PhnD-like", "go_ids": [], "go_terms": [], "name": "ABC_peri_PhnD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030837": {"description": "B12 lower ligand biosynthesis radical SAM protein BzaD-like", "go_ids": [], "go_terms": [], "name": "BzaD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030838": {"description": "Small ribosomal subunit protein eS1, archaea", "go_ids": ["GO:0003735", "GO:0006412", "GO:0005840"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0006412:translation:P", "GO:0005840:ribosome:C"], "name": "Ribosomal_eS1_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030842": {"description": "Transcription factor NusA, prokaryotes", "go_ids": ["GO:0031564", "GO:0006353"], "go_terms": ["GO:0031564:transcription antitermination:P", "GO:0006353:DNA-templated transcription termination:P"], "name": "TF_NusA_prokaryotes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030844": {"description": "PAN2-PAN3 deadenylation complex subunit PAN3", "go_ids": ["GO:0000289", "GO:0031251", "GO:0003723"], "go_terms": ["GO:0000289:nuclear-transcribed mRNA poly(A) tail shortening:P", "GO:0031251:PAN complex:C", "GO:0003723:RNA binding:F"], "name": "PAN3", "pathway_ids": ["R-MMU-429947", "R-DME-429947", "R-SPO-429947", "R-HSA-429947", "R-SCE-429947"], "pathways": ["R-MMU-429947:r:Deadenylation of mRNA", "R-DME-429947:r:Deadenylation of mRNA", "R-SPO-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-SCE-429947:r:Deadenylation of mRNA"], "type": "Family"}, "IPR030846": {"description": "DNA primase DnaG, bacteria", "go_ids": ["GO:0003899", "GO:0006269", "GO:0008270"], "go_terms": ["GO:0003899:DNA-directed RNA polymerase activity:F", "GO:0006269:DNA replication, synthesis of primer:P", "GO:0008270:zinc ion binding:F"], "name": "DnaG_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030850": {"description": "Exosome complex component Csl4, archaea", "go_ids": ["GO:0006396", "GO:0000178"], "go_terms": ["GO:0006396:RNA processing:P", "GO:0000178:exosome (RNase complex):C"], "name": "Exosome_Csl4_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030852": {"description": "Outer membrane lipoprotein RcsF", "go_ids": ["GO:0035556", "GO:0009279"], "go_terms": ["GO:0035556:intracellular signal transduction:P", "GO:0009279:cell outer membrane:C"], "name": "RcsF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030853": {"description": "3-5 exoribonuclease, actinobacteria", "go_ids": ["GO:0008408", "GO:0000287"], "go_terms": ["GO:0008408:3'-5' exonuclease activity:F", "GO:0000287:magnesium ion binding:F"], "name": "3_5_Exoribonuc_actinobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030854": {"description": "Ribonuclease J, bacteria", "go_ids": ["GO:0008270", "GO:0004521", "GO:0004534", "GO:0006396"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0004521:RNA endonuclease activity:F", "GO:0004534:5'-3' RNA exonuclease activity:F", "GO:0006396:RNA processing:P"], "name": "RNase_J_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030856": {"description": "Sensor histidine kinase RcsC", "go_ids": ["GO:0000160", "GO:0016020", "GO:0000155"], "go_terms": ["GO:0000160:phosphorelay signal transduction system:P", "GO:0016020:membrane:C", "GO:0000155:phosphorelay sensor kinase activity:F"], "name": "RcsC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030857": {"description": "Lipid A biosynthesis palmitoleoyltransferase, LpxP", "go_ids": ["GO:0008951", "GO:0036104", "GO:0009409"], "go_terms": ["GO:0008951:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity:F", "GO:0036104:Kdo2-lipid A biosynthetic process:P", "GO:0009409:response to cold:P"], "name": "Lipid_A_LpxP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030861": {"description": "Phosphotransferase RcsD", "go_ids": ["GO:0000160", "GO:0009927", "GO:0005886"], "go_terms": ["GO:0000160:phosphorelay signal transduction system:P", "GO:0009927:histidine phosphotransfer kinase activity:F", "GO:0005886:plasma membrane:C"], "name": "Ptransferase_RcsD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030863": {"description": "1,4-dihydroxy-2-naphthoyl-CoA hydrolase, MenI", "go_ids": ["GO:0061522", "GO:0009234"], "go_terms": ["GO:0061522:1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity:F", "GO:0009234:menaquinone biosynthetic process:P"], "name": "MenI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030864": {"description": "Transcriptional regulatory protein RcsB", "go_ids": ["GO:0006355", "GO:0000160"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0000160:phosphorelay signal transduction system:P"], "name": "RcsB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030866": {"description": "Transcriptional regulatory protein RcsA", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "RcsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030868": {"description": "Chorismate dehydratase", "go_ids": ["GO:0009234", "GO:0016829"], "go_terms": ["GO:0009234:menaquinone biosynthetic process:P", "GO:0016829:lyase activity:F"], "name": "MqnA", "pathway_ids": ["PWY-7371", "PWY-7374"], "pathways": ["PWY-7371:t:1,4-dihydroxy-6-naphthoate biosynthesis II", "PWY-7374:t:1,4-dihydroxy-6-naphthoate biosynthesis I"], "type": "Family"}, "IPR030869": {"description": "1,4-dihydroxy-6-naphtoate synthase", "go_ids": ["GO:0009234", "GO:0016829"], "go_terms": ["GO:0009234:menaquinone biosynthetic process:P", "GO:0016829:lyase activity:F"], "name": "MqnD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030872": {"description": "Cardiolipin synthase B", "go_ids": ["GO:0008808", "GO:0032049"], "go_terms": ["GO:0008808:cardiolipin synthase activity:F", "GO:0032049:cardiolipin biosynthetic process:P"], "name": "Cardiolipin_synth_ClsB", "pathway_ids": ["PWY-6580", "PWY-6350", "PWY-7817", "PWY-7981", "PWY-7819", "PWY-6804", "PWY-7820", "PWY-8248", "PWY-7816", "PWY-7818", "PWY-7815"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-6350:t:archaetidylinositol biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-6804:t:diacylglycerol biosynthesis (PUFA enrichment in oilseed)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"], "type": "Family"}, "IPR030876": {"description": "3-sulfolactaldehyde reductase", "go_ids": ["GO:0061596", "GO:1902777"], "go_terms": ["GO:0061596:3-sulfolactaldehyde reductase activity:F", "GO:1902777:6-sulfoquinovose(1-) catabolic process:P"], "name": "SLA_reductase", "pathway_ids": ["PWY-7446"], "pathways": ["PWY-7446:t:sulfoquinovose degradation I"], "type": "Family"}, "IPR030884": {"description": "Uncharacterised protein family CHP04551", "go_ids": [], "go_terms": [], "name": "CHP04551", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030885": {"description": "Putative large structural protein", "go_ids": [], "go_terms": [], "name": "Lepto_longest", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030886": {"description": "Lipoprotein, tandem type", "go_ids": [], "go_terms": [], "name": "Lepto_lipo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030887": {"description": "YaiO, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "Beta-barrel_YaiO", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030888": {"description": "Putative ccm operon protein", "go_ids": [], "go_terms": [], "name": "Put_ccm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030889": {"description": "Three transmembrane helix protein", "go_ids": [], "go_terms": [], "name": "3TM_Mycoplasma", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030890": {"description": "Substrate import-associated zinc metallohydrolase lipoprotein", "go_ids": [], "go_terms": [], "name": "LP_HExxH_w_TonB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030891": {"description": "HaoA-associated protein HaoB", "go_ids": [], "go_terms": [], "name": "HaoB_nitrify", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030892": {"description": "DnaD family protein", "go_ids": [], "go_terms": [], "name": "DnaD_Mollicutes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030893": {"description": "MOLPALP family lipoprotein", "go_ids": [], "go_terms": [], "name": "Mollicu_LP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030894": {"description": "Fe-coproporphyrin III synthase AhbC, Proteobacteria type", "go_ids": [], "go_terms": [], "name": "Ahb_Proteobacteria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030895": {"description": "T5SS/PEP-CTERM-associated repeat", "go_ids": [], "go_terms": [], "name": "T5SS_PEPC_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR030896": {"description": "AdoMet-dependent heme synthase AhbD", "go_ids": ["GO:0051539"], "go_terms": ["GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "rSAM_AhbD_hemeb", "pathway_ids": ["PWY-7552"], "pathways": ["PWY-7552:t:heme b biosynthesis III (from siroheme)"], "type": "Family"}, "IPR030897": {"description": "Choline trimethylamine-lyase", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "Choline_CutC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030898": {"description": "Beta-methylarginine biosynthesis bifunctional aminotransferase", "go_ids": [], "go_terms": [], "name": "3metArgNH2trans", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030899": {"description": "2-ketoarginine methyltransferase", "go_ids": [], "go_terms": [], "name": "MrsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030900": {"description": "GMC family mycofactocin-associated oxidreductase", "go_ids": [], "go_terms": [], "name": "GMC_mycofac_OxRdtase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030901": {"description": "Thiaminase-1", "go_ids": [], "go_terms": [], "name": "Thiaminase_BcmE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030902": {"description": "Conserved hypothetical protein", "go_ids": [], "go_terms": [], "name": "CLB_0814_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030903": {"description": "Cyclodipeptide synthase", "go_ids": ["GO:0016755"], "go_terms": ["GO:0016755:aminoacyltransferase activity:F"], "name": "CDPS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030904": {"description": "Cytochrome P450, CypX", "go_ids": ["GO:0005506", "GO:0020037", "GO:0046148", "GO:0016705", "GO:0004497"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0020037:heme binding:F", "GO:0046148:pigment biosynthetic process:P", "GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F", "GO:0004497:monooxygenase activity:F"], "name": "CypX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030905": {"description": "Choline TMA-lyase-activating enzyme", "go_ids": [], "go_terms": [], "name": "CutC_activ_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030906": {"description": "Surface carbohydrate biosynthesis protein", "go_ids": [], "go_terms": [], "name": "Surf_polysacc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030907": {"description": "Encapsulin-associated ferritin-like", "go_ids": ["GO:0004322", "GO:0140737"], "go_terms": ["GO:0004322:ferroxidase activity:F", "GO:0140737:encapsulin nanocompartment:C"], "name": "Ferrit_encaps", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030908": {"description": "Protein translocase subunit SecA 2, Bacillus anthracis-type", "go_ids": [], "go_terms": [], "name": "SecA2_Bac_anthr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030909": {"description": "IMEF encapsulin system ferritin-like cargo", "go_ids": ["GO:0004322", "GO:0140315", "GO:0140737"], "go_terms": ["GO:0004322:ferroxidase activity:F", "GO:0140315:iron ion sequestering activity:F", "GO:0140737:encapsulin nanocompartment:C"], "name": "IMEF_cargo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030910": {"description": "SLAP domain", "go_ids": [], "go_terms": [], "name": "SLAP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030911": {"description": "Accessory Sec system S-layer assembly protein", "go_ids": [], "go_terms": [], "name": "Sec_acc_SLAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030912": {"description": "Arg-Lys translocation region protein phosphatase RktP", "go_ids": [], "go_terms": [], "name": "RK_trnsloc_Pase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030913": {"description": "Copper storage protein 1 family", "go_ids": [], "go_terms": [], "name": "Csp1_Cys_rich", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030914": {"description": "Mobilome CxxCx(11)CxxC protein", "go_ids": [], "go_terms": [], "name": "Mob_CxxC_CxxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030915": {"description": "Sporulation killing factor system, radical SAM maturase SkfB", "go_ids": [], "go_terms": [], "name": "rSAM_SkfB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030916": {"description": "ELWxxDGT repeat", "go_ids": [], "go_terms": [], "name": "ELWxxDGT_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR030917": {"description": "Cyanoexosortase B-associated protein", "go_ids": [], "go_terms": [], "name": "Cyanoexo_CrtB_assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030918": {"description": "Polyketide product template domain", "go_ids": [], "go_terms": [], "name": "PT_fungal_PKS", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR030919": {"description": "Sporulation killing factor SkfA", "go_ids": [], "go_terms": [], "name": "RiPP_SkfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030920": {"description": "Sporulation killing factor system integral membrane protein SkfF", "go_ids": [], "go_terms": [], "name": "SkfF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030921": {"description": "LPS export ABC transporter, ATP-binding protein LptB", "go_ids": ["GO:0043190", "GO:0055085"], "go_terms": ["GO:0043190:ATP-binding cassette (ABC) transporter complex:C", "GO:0055085:transmembrane transport:P"], "name": "LPS_export_LptB", "pathway_ids": ["PWY-7037", "PWY-7658", "PWY-7031", "PWYG-321", "PWY-7789", "PWY-8250", "PWY-8257"], "pathways": ["PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7031:t:protein N-glycosylation (bacterial)", "PWYG-321:t:mycolate biosynthesis", "PWY-7789:t:erythritol degradation I", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis"], "type": "Family"}, "IPR030922": {"description": "LPS export ABC transporter permease LptF", "go_ids": ["GO:0055085", "GO:0043190"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0043190:ATP-binding cassette (ABC) transporter complex:C"], "name": "LptF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030923": {"description": "LPS export ABC transporter permease LptG", "go_ids": ["GO:0043190", "GO:0055085"], "go_terms": ["GO:0043190:ATP-binding cassette (ABC) transporter complex:C", "GO:0055085:transmembrane transport:P"], "name": "LptG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030924": {"description": "Type II secretion system-associated lipoprotein", "go_ids": [], "go_terms": [], "name": "Spiro_T2SS_lipo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030925": {"description": "Type II secretion system protein GspN, Leptospira-type", "go_ids": [], "go_terms": [], "name": "T2SS_GspN_Lepto", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030927": {"description": "Type II secretion system protein GspM, XcpZ-type", "go_ids": [], "go_terms": [], "name": "T2SS_GspM_XcpZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030928": {"description": "CRISPR type MYXAN-associated protein Cmx8", "go_ids": [], "go_terms": [], "name": "MYXAN_cmx8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030929": {"description": "Glycosyltransferase Aah/TibC-like", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "Aah/TibC-like", "pathway_ids": ["PWY-8243", "PWY-8133", "PWY-8366", "PWY-7676"], "pathways": ["PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-7676:t:Kdo8N transfer to lipid IVA"], "type": "Family"}, "IPR030930": {"description": "Adhesin of bacterial autotransporter system", "go_ids": [], "go_terms": [], "name": "AIDA", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR030931": {"description": "Group II intron reverse transcriptase/maturase", "go_ids": [], "go_terms": [], "name": "Group_II_RT_mat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030932": {"description": "Polysaccharide biosynthesis PFTS motif protein", "go_ids": [], "go_terms": [], "name": "PFTS_polysacc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030933": {"description": "HemN-related non-iron pseudo-SAM protein PsgB", "go_ids": [], "go_terms": [], "name": "Non_iron_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030934": {"description": "Intein C-terminal splicing region", "go_ids": [], "go_terms": [], "name": "Intein_C", "pathway_ids": ["R-SCE-917977", "R-SCE-1222556", "R-DDI-76066", "R-DDI-76061", "R-SCE-77387", "R-SCE-9639288"], "pathways": ["R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SCE-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1"], "type": "Conserved_site"}, "IPR030935": {"description": "Phage portal protein PBSX family, Proteobacteria", "go_ids": [], "go_terms": [], "name": "PBSX_Proteobac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030936": {"description": "Putative nonproteinogenic amino acid hydroxylase", "go_ids": [], "go_terms": [], "name": "Nonproteo_OH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030937": {"description": "Hemophore Rv0203", "go_ids": ["GO:0020037", "GO:0015886"], "go_terms": ["GO:0020037:heme binding:F", "GO:0015886:heme transport:P"], "name": "Hemophore_Rv0203", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030939": {"description": "Acido-empty-quinoprotein group A", "go_ids": [], "go_terms": [], "name": "Acido_non_PQQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030940": {"description": "Uncharacterised protein MG279/MG280", "go_ids": [], "go_terms": [], "name": "MG279/MG280", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030941": {"description": "Putative immunoglobulin-blocking virulence protein", "go_ids": [], "go_terms": [], "name": "Predic_Ig_block", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030942": {"description": "IgG-blocking virulence domain", "go_ids": [], "go_terms": [], "name": "Mycoplas_M_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030943": {"description": "IgG-blocking protein M", "go_ids": [], "go_terms": [], "name": "M_MG281", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030944": {"description": "Helix-rich protein", "go_ids": [], "go_terms": [], "name": "Mplasa_alph_rch", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030945": {"description": "Putative energy coupling factor transporter S component", "go_ids": [], "go_terms": [], "name": "EcfS_MSC_0063", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030946": {"description": "Energy-coupling factor transporter ATP-binding protein EcfA2", "go_ids": [], "go_terms": [], "name": "EcfA2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030947": {"description": "Energy-coupling factor transporter EcfA1", "go_ids": [], "go_terms": [], "name": "EcfA_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030948": {"description": "TAT-variant-translocation signal domain", "go_ids": [], "go_terms": [], "name": "TAT_var_transloc_signal_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030949": {"description": "ECF transporter S component, folate family", "go_ids": [], "go_terms": [], "name": "ECF_S_folate_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030950": {"description": "Radical SAM family RiPP maturation amino acid epimerase", "go_ids": [], "go_terms": [], "name": "rSAM_PoyD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030951": {"description": "Sec region non-globular protein", "go_ids": [], "go_terms": [], "name": "Sec_Non_Glob", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030952": {"description": "FemAB family protein", "go_ids": [], "go_terms": [], "name": "FemAB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030953": {"description": "Glycosyltransferase, activator-dependent family", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "Glycosyl_450act", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030954": {"description": "Putative PLP-dependent aminotransferase", "go_ids": [], "go_terms": [], "name": "PLP_IMCC1989", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030955": {"description": "CRISPR type III-associated protein, CHP04423 family", "go_ids": [], "go_terms": [], "name": "CHP04423", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030956": {"description": "Microcin B17-processing protein McbB", "go_ids": [], "go_terms": [], "name": "McbB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030957": {"description": "AroB-related putative sugar phosphate phospholyase (cyclising)", "go_ids": [], "go_terms": [], "name": "Put_AroB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030958": {"description": "P450-derived glycosyltranferase activator", "go_ids": [], "go_terms": [], "name": "P450-rel_GT_act", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030959": {"description": "GWxTD domain", "go_ids": [], "go_terms": [], "name": "GWxTD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030960": {"description": "3-dehydroquinate synthase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DHQS/DOIS_N", "pathway_ids": ["PWY-6164", "R-MTU-964903"], "pathways": ["PWY-6164:t:3-dehydroquinate biosynthesis I", "R-MTU-964903:r:Chorismate via Shikimate Pathway"], "type": "Domain"}, "IPR030961": {"description": "VPAMP-CTERM protein sorting domain", "go_ids": [], "go_terms": [], "name": "VPAMP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030962": {"description": "STREFT protein", "go_ids": [], "go_terms": [], "name": "Mycopla_NOT_gsn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030963": {"description": "3-dehydroquinate synthase family", "go_ids": ["GO:0016838", "GO:0009073"], "go_terms": ["GO:0016838:carbon-oxygen lyase activity, acting on phosphates:F", "GO:0009073:aromatic amino acid biosynthetic process:P"], "name": "DHQ_synth_fam", "pathway_ids": ["PWY-6164", "R-MTU-964903"], "pathways": ["PWY-6164:t:3-dehydroquinate biosynthesis I", "R-MTU-964903:r:Chorismate via Shikimate Pathway"], "type": "Family"}, "IPR030965": {"description": "Putative peptide maturation dehydrogenase", "go_ids": [], "go_terms": [], "name": "SagB-rel_DH_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030966": {"description": "Putative peptide modification system cyclase", "go_ids": [], "go_terms": [], "name": "Mod_pep_cyc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030967": {"description": "dTDP-4-dehydro-6-deoxyglucose aminotransferase", "go_ids": [], "go_terms": [], "name": "PLP_DesI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030968": {"description": "RapG/RapK inhibitor", "go_ids": [], "go_terms": [], "name": "RapG/K_inhib", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030969": {"description": "Tryptophan 2-C-methyltransferase", "go_ids": [], "go_terms": [], "name": "B12_rSAM_trp_MT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030970": {"description": "Probable phospholipid ABC transporter-binding protein MlaD", "go_ids": ["GO:0015914"], "go_terms": ["GO:0015914:phospholipid transport:P"], "name": "ABC_MlaD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030971": {"description": "Aminoglycoside N(6')-acetyltransferase, AacA4 type", "go_ids": [], "go_terms": [], "name": "N6_acetyl_AAC6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030972": {"description": "UrcA family protein", "go_ids": [], "go_terms": [], "name": "UrcA_uranyl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030973": {"description": "Conserved hypothetical protein CHP04434", "go_ids": [], "go_terms": [], "name": "CHP04434", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030974": {"description": "Restriction system-associated AAA family ATPase", "go_ids": [], "go_terms": [], "name": "Restrict_AAA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030975": {"description": "Putative 2OG-Fe(II) oxygenase", "go_ids": [], "go_terms": [], "name": "SpoChoClust_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030976": {"description": "Putative modified peptide", "go_ids": [], "go_terms": [], "name": "Mod_pep_NH_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030977": {"description": "7-carboxy-7-deazaguanine synthase, Cx14CxxC-type", "go_ids": ["GO:0008616", "GO:0046872"], "go_terms": ["GO:0008616:tRNA queuosine(34) biosynthetic process:P", "GO:0046872:metal ion binding:F"], "name": "QueE_Cx14CxxC", "pathway_ids": ["PWY-6703"], "pathways": ["PWY-6703:t:preQ0 biosynthesis"], "type": "Family"}, "IPR030978": {"description": "Fluorinase", "go_ids": ["GO:0033846"], "go_terms": ["GO:0033846:adenosyl-fluoride synthase activity:F"], "name": "Fluorinase", "pathway_ids": ["PWY-6644"], "pathways": ["PWY-6644:t:fluoroacetate and fluorothreonine biosynthesis"], "type": "Family"}, "IPR030979": {"description": "Fluorothreonine transaldolase", "go_ids": ["GO:0033806"], "go_terms": ["GO:0033806:fluorothreonine transaldolase activity:F"], "name": "F_threo_transal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030980": {"description": "Phosphate ABC transporter substrate-binding protein", "go_ids": [], "go_terms": [], "name": "PtsS_plasma", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030981": {"description": "SDR family mycofactocin-dependent oxidoreductase", "go_ids": [], "go_terms": [], "name": "SDR_subfam_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030982": {"description": "Electron transfer flavoprotein, mycofactocin-associated", "go_ids": [], "go_terms": [], "name": "Mft_EtfB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030983": {"description": "Bacterial microcompartment shell protein EutL", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "EutL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030984": {"description": "Bacterial microcompartment shell protein PduB", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "PduB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030985": {"description": "Putative peptide maturation system protein", "go_ids": [], "go_terms": [], "name": "PpiC-rel_mature", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030986": {"description": "Abortive infection protein, AbiA family", "go_ids": [], "go_terms": [], "name": "AbiA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030987": {"description": "Abortive infection protein, AbiV family", "go_ids": [], "go_terms": [], "name": "AbiV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030988": {"description": "Putative ATP-grasp target RiPP", "go_ids": [], "go_terms": [], "name": "GRASP_targ_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030989": {"description": "Radical SAM/SPASM domain peptide maturase, XyeB family", "go_ids": [], "go_terms": [], "name": "rSAM_SPASM_XyeB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030990": {"description": "RiPP peptide, XyeA family", "go_ids": [], "go_terms": [], "name": "RiPP_XyeA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030991": {"description": "Cytochrome c-550, proteobacteria", "go_ids": [], "go_terms": [], "name": "c550_proteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030992": {"description": "Bacterial microcompartment assembly protein PduM", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "PduM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030993": {"description": "Violacein biosynthesis protein VioB", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "VioB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030994": {"description": "Diol dehydratase reactivase ATPase-like domain", "go_ids": [], "go_terms": [], "name": "DDR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR030995": {"description": "Thiosulfate oxidation carrier complex protein SoxZ", "go_ids": [], "go_terms": [], "name": "SoxZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030996": {"description": "Exosortase O", "go_ids": [], "go_terms": [], "name": "Exosort_XrtO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030997": {"description": "SoxY-related AACIE arm protein", "go_ids": [], "go_terms": [], "name": "SoxY_para_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030998": {"description": "Thiosulfohydrolase SoxB", "go_ids": [], "go_terms": [], "name": "Thiosulf_SoxB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR030999": {"description": "Sulfur oxidation c-type cytochrome SoxX", "go_ids": [], "go_terms": [], "name": "Thiosulf_SoxX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031000": {"description": "Proline reductase cluster protein PrdD", "go_ids": [], "go_terms": [], "name": "D_pro_red_PrdD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031001": {"description": "Proline reductase-associated electron transfer protein PrdC", "go_ids": [], "go_terms": [], "name": "PR_assoc_PrdC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031002": {"description": "D-proline reductase, PrdA proprotein", "go_ids": ["GO:0050002"], "go_terms": ["GO:0050002:D-proline reductase activity:F"], "name": "D_pro_red_PrdA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031003": {"description": "Radical SAM P-methyltransferase, PhpK family", "go_ids": [], "go_terms": [], "name": "BcpD_PhpK_rSAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031004": {"description": "Radical SAM/CxCxxxxC motif protein YfkAB", "go_ids": [], "go_terms": [], "name": "rSAM_YfkAB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031005": {"description": "XrtN system VIT domain protein", "go_ids": [], "go_terms": [], "name": "Sorted_by_XrtN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031006": {"description": "Exosortase N", "go_ids": [], "go_terms": [], "name": "Exosort_XrtN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031007": {"description": "Phenylalanine aminomutase (D-beta-phenylalanine forming)", "go_ids": [], "go_terms": [], "name": "Phe_D_beta_mut", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031008": {"description": "Phenylalanine aminomutase (L-beta-phenylalanine forming)", "go_ids": [], "go_terms": [], "name": "Taxol_Phe_23mut", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031009": {"description": "Three-Cys-motif partner protein", "go_ids": [], "go_terms": [], "name": "Tcm_partner", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031010": {"description": "Radical SAM mobile pair protein A", "go_ids": [], "go_terms": [], "name": "rSAM_mob_pairA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031011": {"description": "MarR family transcriptional regulator", "go_ids": [], "go_terms": [], "name": "Reg_MarR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031012": {"description": "Radical SAM mobile pair protein B", "go_ids": [], "go_terms": [], "name": "rSAM_mob_pairB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031013": {"description": "CGA synthase-related protein", "go_ids": [], "go_terms": [], "name": "CGA_synth-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031014": {"description": "Cytosylglucuronate decarboxylase", "go_ids": [], "go_terms": [], "name": "rSAM_BlsE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031015": {"description": "Arginine 2,3-aminomutase", "go_ids": [], "go_terms": [], "name": "Arg_2_3_am_muta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031016": {"description": "Hydroxymethylcytosylglucuronate/cytosylglucuronate synthase", "go_ids": [], "go_terms": [], "name": "CGA_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031017": {"description": "TAT-translocated F420-dependent dehydrogenase, FGD2 family", "go_ids": [], "go_terms": [], "name": "F420_FGD2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031018": {"description": "LipL41-expression chaperone Lep", "go_ids": [], "go_terms": [], "name": "Chaper_lep", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031019": {"description": "Radical SAM/SPASM domain protein maturase", "go_ids": [], "go_terms": [], "name": "rSAM_vs_C_rich", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031020": {"description": "Enduracididine biosynthesis enzyme MppP", "go_ids": [], "go_terms": [], "name": "Endura_MppP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031021": {"description": "Enduracididine biosynthesis enzyme MppQ", "go_ids": [], "go_terms": [], "name": "Endura_MppQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031022": {"description": "Enduracididine biosynthesis enzyme MppR", "go_ids": [], "go_terms": [], "name": "Endura_MppR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031023": {"description": "L-tryptophan 4-nitrase", "go_ids": [], "go_terms": [], "name": "CYP450_TxtE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031024": {"description": "Lipoprotein LenA", "go_ids": [], "go_terms": [], "name": "Lipo_LenA_lepto", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031025": {"description": "LruC domain", "go_ids": [], "go_terms": [], "name": "LruC_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031026": {"description": "3-deoxy-D-manno-octulosonic acid transferase WaaZ, enterobacterales", "go_ids": [], "go_terms": [], "name": "WaaZ_KDO_III_entero", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031027": {"description": "Probable lipoprotein, LA_1396/MXAN_6521 family", "go_ids": [], "go_terms": [], "name": "Lipo_MXAN_6521", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031028": {"description": "Small lipoprotein, LB_250 family", "go_ids": [], "go_terms": [], "name": "Lepto_4Cys", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031029": {"description": "Cys-rich protein, LA_1312 family", "go_ids": [], "go_terms": [], "name": "Lepto_8Cys", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031030": {"description": "Small lipoprotein, LA_3946 family", "go_ids": [], "go_terms": [], "name": "Lepto_Lipo_YY_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031031": {"description": "Lantipeptide, SCO0268 family", "go_ids": [], "go_terms": [], "name": "Lanti_SCO0268", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031032": {"description": "Putative immunity protein/bacteriocin", "go_ids": [], "go_terms": [], "name": "Gpos_C8-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031033": {"description": "Halocin C8-like bacteriocin domain", "go_ids": [], "go_terms": [], "name": "Halocin_C8_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031034": {"description": "Creatinine amidohydrolase", "go_ids": ["GO:0047789", "GO:0006601", "GO:0006602"], "go_terms": ["GO:0047789:creatininase activity:F", "GO:0006601:creatine biosynthetic process:P", "GO:0006602:creatinine catabolic process:P"], "name": "Creatininase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031035": {"description": "Cyanobactin cluster PatC/TenC/TruC protein", "go_ids": [], "go_terms": [], "name": "PatC_TenC_TruC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031036": {"description": "Prenylated cyclic peptide, anacyclamide/piricyclamide family", "go_ids": [], "go_terms": [], "name": "Pren_cyc_PirE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031037": {"description": "Peptide O-prenyltransferase, LynF/TruF/PatF family", "go_ids": [], "go_terms": [], "name": "Preny_LynF_TruF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031038": {"description": "Chorismatase, FkbO/Hyg5 family", "go_ids": [], "go_terms": [], "name": "Chori_FkbO_Hyg5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031039": {"description": "Coenzyme gamma-F420-2:alpha-L-glutamate ligase", "go_ids": ["GO:0043774"], "go_terms": ["GO:0043774:coenzyme F420-2 alpha-glutamyl ligase activity:F"], "name": "F420_CofF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031040": {"description": "Conserved hypothetical protein CHP04442", "go_ids": [], "go_terms": [], "name": "CHP04442", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031041": {"description": "LA_1612 putative O-antigen biosynthesis protein", "go_ids": [], "go_terms": [], "name": "Lept_O_ant_chp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031042": {"description": "Glycosyltransferase domain", "go_ids": [], "go_terms": [], "name": "Glyco_TIGR04440", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031043": {"description": "Rhizobactin siderophore biosynthesis protein RhbE", "go_ids": [], "go_terms": [], "name": "RhbE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031044": {"description": "Small Trp-rich protein", "go_ids": [], "go_terms": [], "name": "Small_Trp_rich", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031046": {"description": "Carnosine synthase 1", "go_ids": ["GO:0016887", "GO:0047730", "GO:0035499"], "go_terms": ["GO:0016887:ATP hydrolysis activity:F", "GO:0047730:carnosine synthase activity:F", "GO:0035499:carnosine biosynthetic process:P"], "name": "CARNS1", "pathway_ids": ["R-MMU-70921", "R-HSA-70921"], "pathways": ["R-MMU-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism"], "type": "Family"}, "IPR031052": {"description": "FHY3/FAR1 family", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "FHY3/FAR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031053": {"description": "Chromodomain-helicase-DNA-binding protein 1-like", "go_ids": ["GO:0003678", "GO:0006281", "GO:0006338"], "go_terms": ["GO:0003678:DNA helicase activity:F", "GO:0006281:DNA repair:P", "GO:0006338:chromatin remodeling:P"], "name": "ALC1", "pathway_ids": ["PWY-7250", "R-DRE-5696395", "R-HSA-5696400", "R-DRE-5696400", "R-MMU-5696395", "R-BTA-5696395", "R-MMU-5696400", "R-BTA-5696400", "R-HSA-5696395"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER"], "type": "Family"}, "IPR031061": {"description": "High mobility group protein HMGB, plant", "go_ids": [], "go_terms": [], "name": "HMGB_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031066": {"description": "Basic helix-loop-helix (bHLH) transcription factors ALC-like, plant", "go_ids": [], "go_terms": [], "name": "bHLH_ALC-like_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031098": {"description": "Crustacean CHH/MIH/GIH neurohormone family", "go_ids": [], "go_terms": [], "name": "Crust_neurohorm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031099": {"description": "BRCA1-associated", "go_ids": ["GO:0006974", "GO:0006281"], "go_terms": ["GO:0006974:DNA damage response:P", "GO:0006281:DNA repair:P"], "name": "BRCA1-associated", "pathway_ids": ["PWY-7511", "R-HSA-5689901", "R-HSA-9825895", "R-HSA-5685942", "R-HSA-3108214", "R-HSA-5693616", "R-HSA-8951664", "R-HSA-9704646", "R-RNO-5693565", "R-MMU-5689901", "R-MMU-6804756", "R-HSA-5693565", "R-RNO-3108214", "R-RNO-5689901", "R-HSA-1221632", "R-HSA-6796648", "R-HSA-8953750", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-5693565", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-5685938", "R-HSA-912446", "R-RNO-6804756", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-HSA-9663199", "R-HSA-9701192", "R-MMU-5693607", "R-RNO-5693579", "R-HSA-69473", "R-RNO-5693607", "R-HSA-9755511", "R-HSA-9709603", "R-MMU-5685942", "R-RNO-5693571", "R-RNO-69473", "R-RNO-5685942", "R-HSA-5693571", "R-HSA-6804756", "R-HSA-9704331", "R-RNO-5693568", "R-RNO-5693616", "R-HSA-5693554", "R-MMU-3108214", "R-HSA-5693579", "R-MMU-5693571", "R-HSA-9699150"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-8951664:r:Neddylation", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-5689901:r:Metalloprotease DUBs", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9663199:r:Defective DNA double strand break response due to BRCA1 loss of function", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9699150:r:Defective DNA double strand break response due to BARD1 loss of function"], "type": "Family"}, "IPR031100": {"description": "LOG family", "go_ids": [], "go_terms": [], "name": "LOG_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031101": {"description": "RNA polymerase-associated protein Ctr9", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Ctr9", "pathway_ids": ["R-CEL-674695", "R-MMU-8866654", "R-HSA-8866654", "R-HSA-112382", "R-CEL-75955", "R-XTR-674695", "R-HSA-75955", "R-CEL-112382", "R-HSA-9920588", "R-XTR-8866654", "R-XTR-75955", "R-XTR-112382", "R-HSA-674695", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-XTR-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Family"}, "IPR031105": {"description": "Telomere repeat-binding protein, plant", "go_ids": [], "go_terms": [], "name": "TRP_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031106": {"description": "CCAAT/enhancer-binding protein C/EBP", "go_ids": ["GO:0006351", "GO:0003700"], "go_terms": ["GO:0006351:DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "C/EBP", "pathway_ids": ["R-HSA-8853884", "R-HSA-9610379", "R-RNO-2559582", "R-HSA-381340", "R-MMU-2559582", "R-HSA-2559582", "R-HSA-6785807", "R-HSA-9841922", "R-CEL-9616222", "R-HSA-9648895", "R-HSA-9725371", "R-HSA-380994", "R-CEL-2559582", "R-GGA-2559582", "R-HSA-9616222", "R-MMU-9616222", "R-RNO-9616222", "R-HSA-9633012"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9610379:r:HCMV Late Events", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-CEL-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-GGA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-9616222:r:Transcriptional regulation of granulopoiesis", "R-RNO-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR031107": {"description": "Small heat shock protein", "go_ids": [], "go_terms": [], "name": "Small_HSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031108": {"description": "FeS A-type assembly protein IscA, plant/cyanobacteria", "go_ids": ["GO:0016226", "GO:0051536"], "go_terms": ["GO:0016226:iron-sulfur cluster assembly:P", "GO:0051536:iron-sulfur cluster binding:F"], "name": "IscA_plant_cyanobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031120": {"description": "WD repeat HIR1-like", "go_ids": ["GO:0006325", "GO:0005634", "GO:0006351"], "go_terms": ["GO:0006325:chromatin organization:P", "GO:0005634:nucleus:C", "GO:0006351:DNA-templated transcription:P"], "name": "HIR1-like", "pathway_ids": ["R-SCE-2559584", "R-HSA-2559584", "R-HSA-9821993", "R-MMU-2559584", "R-CEL-2559584"], "pathways": ["R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Family"}, "IPR031121": {"description": "KH domain containing protein RIK/BLOM7", "go_ids": ["GO:0003723", "GO:0005634"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005634:nucleus:C"], "name": "RIK/BLOM7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031127": {"description": "E3 ubiquitin ligase RBR family", "go_ids": ["GO:0016567", "GO:0004842"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0004842:ubiquitin-protein transferase activity:F"], "name": "E3_UB_ligase_RBR", "pathway_ids": ["R-BTA-9909505", "R-DME-983168", "R-DDI-9833482", "R-MMU-9909505", "R-SSC-983168", "R-HSA-9833482", "R-DME-5689877", "R-CEL-9833482", "R-DME-9646399", "R-HSA-983168", "R-HSA-1169408", "R-MMU-1169408", "R-CEL-983168", "R-HSA-9909505", "R-DRE-8866654", "R-DRE-983168", "R-HSA-8866654", "R-DDI-983168", "R-MMU-9833482", "R-CEL-9909505", "R-CEL-1169408", "R-DDI-9909505", "R-DME-5205685", "R-MMU-983168", "R-SPO-983168", "R-SCE-9646399", "R-HSA-9833110", "R-SCE-983168", "R-BTA-1169408", "R-SCE-5205685", "R-BTA-9833482", "R-DDI-1169408", "R-MMU-8866654"], "pathways": ["R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9833482:r:PKR-mediated signaling", "R-DME-5689877:r:Josephin domain DUBs", "R-CEL-9833482:r:PKR-mediated signaling", "R-DME-9646399:r:Aggrephagy", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DRE-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9833482:r:PKR-mediated signaling", "R-CEL-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9646399:r:Aggrephagy", "R-HSA-9833110:r:RSV-host interactions", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-SCE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-9833482:r:PKR-mediated signaling", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Family"}, "IPR031137": {"description": "Growth-regulating factor", "go_ids": ["GO:0005634", "GO:0006351", "GO:0032502"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006351:DNA-templated transcription:P", "GO:0032502:developmental process:P"], "name": "GRF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031139": {"description": "RPGRIP1 family", "go_ids": [], "go_terms": [], "name": "RPGRIP1_fam", "pathway_ids": ["R-HSA-5610787", "R-MMU-5610787", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR031140": {"description": "Protein indeterminate-domain 1-16", "go_ids": [], "go_terms": [], "name": "IDD1-16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031142": {"description": "SPX domain-containing protein", "go_ids": ["GO:0016036"], "go_terms": ["GO:0016036:cellular response to phosphate starvation:P"], "name": "SPX_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031148": {"description": "Plexin family", "go_ids": ["GO:0017154", "GO:0071526"], "go_terms": ["GO:0017154:semaphorin receptor activity:F", "GO:0071526:semaphorin-plexin signaling pathway:P"], "name": "Plexin", "pathway_ids": ["R-HSA-9013405", "R-HSA-8874081", "R-HSA-8875555", "R-DRE-399954", "R-MMU-6811558", "R-MMU-8875791", "R-CEL-416482", "R-RNO-416550", "R-MMU-416572", "R-MMU-8865999", "R-SSC-6811558", "R-HSA-6806942", "R-RNO-399954", "R-MMU-8851805", "R-RNO-6811558", "R-MMU-399954", "R-HSA-399955", "R-HSA-8875513", "R-HSA-9825892", "R-RNO-8865999", "R-MMU-5673001", "R-RNO-5673001", "R-RNO-6806942", "R-MMU-399955", "R-HSA-416482", "R-HSA-2219530", "R-SSC-416550", "R-HSA-5673001", "R-HSA-6811558", "R-MMU-8875555", "R-RNO-8875656", "R-DME-416572", "R-RNO-8851805", "R-HSA-399954", "R-DRE-399956", "R-DME-416482", "R-MMU-8875513", "R-SSC-6806942", "R-DME-416700", "R-RNO-8875555", "R-HSA-1257604", "R-SSC-9734091", "R-MMU-399956", "R-MMU-416700", "R-HSA-8865999", "R-RNO-8851907", "R-MMU-416550", "R-SSC-1257604", "R-SSC-8875513", "R-HSA-416550", "R-HSA-399956", "R-HSA-416572", "R-RNO-1257604", "R-CEL-416700", "R-RNO-9734091", "R-RNO-8874081", "R-RNO-8875513", "R-MMU-8874081", "R-HSA-9615017", "R-HSA-416700", "R-HSA-8851907", "R-SSC-8874081", "R-HSA-8851805", "R-SSC-8851907", "R-MMU-9734091", "R-HSA-9734091", "R-RNO-399956", "R-HSA-8875791", "R-SSC-6807004", "R-HSA-9013508", "R-HSA-9696270", "R-RNO-416700", "R-RNO-8875791", "R-SSC-8875555", "R-MMU-1257604", "R-HSA-6807004", "R-CEL-416572", "R-RNO-6807004", "R-SSC-5673001", "R-MMU-6806942", "R-RNO-399955", "R-MMU-8851907", "R-MMU-8875656", "R-MMU-416482", "R-SSC-8875791", "R-HSA-9022699", "R-MMU-6807004", "R-SSC-8865999", "R-HSA-8875656", "R-SSC-8851805", "R-MMU-9696273", "R-MMU-9696270", "R-SSC-8875656", "R-HSA-8875360", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8875791:r:MET activates STAT3", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-8865999:r:MET activates PTPN11", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-RNO-8865999:r:MET activates PTPN11", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-6806942:r:MET Receptor Activation", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin 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polymerase II transcribes snRNA genes", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Family"}, "IPR031211": {"description": "Nestin", "go_ids": ["GO:0019215"], "go_terms": ["GO:0019215:intermediate filament binding:F"], "name": "Nestin", "pathway_ids": [], 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"PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7511:t:protein ubiquitination", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR031259": {"description": "Intracellular lipid binding protein", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "ILBP", "pathway_ids": ["R-RNO-6798695", "R-HSA-1989781", "R-HSA-6798695", "R-BTA-5365859", "R-HSA-9725554", "R-CEL-5365859", "R-BTA-400206", "R-CEL-6798695", "R-BTA-5362517", "R-CEL-2453902", "R-BTA-6798695", "R-DRE-400206", "R-HSA-9841922", "R-HSA-189483", "R-RNO-5362517", "R-MMU-975634", "R-MMU-189483", "R-MMU-159418", "R-RNO-159418", "R-BTA-189483", "R-CEL-159418", "R-HSA-9707564", "R-MMU-163560", "R-RNO-975634", "R-HSA-9918442", "R-DRE-189483", "R-BTA-9707564", "R-RNO-189483", "R-HSA-5362517", "R-DRE-163560", "R-HSA-9623433", "R-CEL-163560", "R-HSA-9013508", "R-RNO-400206", "R-RNO-5365859", "R-CEL-189483", "R-CEL-5362517", "R-HSA-381340", "R-MMU-2453902", "R-RNO-9707564", "R-HSA-5365859", "R-RNO-2453902", "R-CEL-975634", "R-BTA-163560", "R-HSA-163560", "R-SSC-163560", "R-RNO-163560", "R-MMU-5365859", "R-MMU-5362517", 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PPARalpha", "R-RNO-5365859:r:RA biosynthesis pathway", "R-CEL-189483:r:Heme degradation", "R-CEL-5362517:r:Signaling by Retinoic Acid", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-5365859:r:RA biosynthesis pathway", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CEL-975634:r:Retinoid metabolism and transport", "R-BTA-163560:r:Triglyceride catabolism", "R-HSA-163560:r:Triglyceride catabolism", "R-SSC-163560:r:Triglyceride catabolism", "R-RNO-163560:r:Triglyceride catabolism", "R-MMU-5365859:r:RA biosynthesis pathway", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-159418:r:Recycling of bile acids and salts", 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{"description": "CcdC protein", "go_ids": [], "go_terms": [], "name": "CcdC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031307": {"description": "Ninja family", "go_ids": ["GO:0007165"], "go_terms": ["GO:0007165:signal transduction:P"], "name": "Ninja_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031308": {"description": "Inner membrane protein YccF", "go_ids": [], "go_terms": [], "name": "YccF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031309": {"description": "Large ribosomal subunit protein uL5, C-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL5_C", "pathway_ids": ["R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", 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"R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956"], "pathways": ["R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "type": "Domain"}, "IPR031313": {"description": "SAPK-interacting protein 1, Pleckstrin-homology domain", "go_ids": [], "go_terms": [], "name": "Sin1_PH_dom", "pathway_ids": ["R-MMU-9856530", "R-SPO-6804757", "R-MMU-5218920", "R-HSA-5674400", "R-RNO-1257604", "R-MMU-6804757", "R-SPO-389357", "R-GGA-6804757", "R-SPO-5218920", "R-MMU-1257604", "R-SCE-389357", "R-GGA-389357", "R-RNO-5218920", "R-DME-5218920", "R-RNO-9856530", "R-MMU-389357", "R-RNO-6804757", "R-HSA-5218920", "R-SCE-6804757", "R-DME-9856530", "R-HSA-6804757", "R-DME-1257604", "R-GGA-9856530", "R-HSA-389357", "R-SCE-1257604", "R-HSA-9920951", "R-HSA-9856530", "R-SPO-9856530", "R-HSA-1257604", "R-SPO-1257604", "R-GGA-5218920", "R-DME-389357", "R-SCE-9856530", "R-GGA-1257604", "R-SCE-5218920", "R-RNO-389357"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-GGA-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-GGA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-GGA-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling"], "type": "Domain"}, "IPR031314": {"description": "Deoxynucleoside kinase domain", "go_ids": [], "go_terms": [], "name": "DNK_dom", "pathway_ids": ["R-BTA-74217", "R-HSA-73614", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-RNO-74217", "R-RNO-6799198", "R-MMU-73614", "R-DME-73614", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-DDI-74217", "R-RNO-73614", "R-MMU-74217", "R-MMU-611105", "R-HSA-74217", "R-BTA-73614", "R-DDI-73614"], "pathways": ["R-BTA-74217:r:Purine salvage", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-74217:r:Purine salvage", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-73614:r:Pyrimidine salvage", "R-DME-73614:r:Pyrimidine salvage", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-DDI-74217:r:Purine salvage", "R-RNO-73614:r:Pyrimidine salvage", "R-MMU-74217:r:Purine salvage", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-74217:r:Purine salvage", "R-BTA-73614:r:Pyrimidine salvage", "R-DDI-73614:r:Pyrimidine salvage"], "type": "Domain"}, "IPR031315": {"description": "LNS2/PITP", "go_ids": [], "go_terms": [], "name": "LNS2/PITP", "pathway_ids": ["R-HSA-1483226", "R-SCE-75109", "R-MMU-75109", "R-MMU-1483191", "R-MMU-1483226", "R-SPO-4419969", "R-MMU-1483213", "R-DME-1483226", "R-HSA-9841922", "R-HSA-1483191", "R-SPO-75109", "R-HSA-4419969", "R-HSA-1483213", "R-SCE-1483213", "R-HSA-75109", "R-SPO-1483213", "R-SCE-1483191", "R-MMU-4419969", "R-SCE-4419969", "R-RNO-1483226", "R-SPO-1483191"], "pathways": ["R-HSA-1483226:r:Synthesis of PI", "R-SCE-75109:r:Triglyceride biosynthesis", "R-MMU-75109:r:Triglyceride biosynthesis", "R-MMU-1483191:r:Synthesis of PC", "R-MMU-1483226:r:Synthesis of PI", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-1483213:r:Synthesis of PE", "R-DME-1483226:r:Synthesis of PI", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-1483191:r:Synthesis of PC", "R-SPO-75109:r:Triglyceride biosynthesis", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-1483213:r:Synthesis of PE", "R-SCE-1483213:r:Synthesis of PE", "R-HSA-75109:r:Triglyceride biosynthesis", "R-SPO-1483213:r:Synthesis of PE", "R-SCE-1483191:r:Synthesis of PC", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-1483226:r:Synthesis of PI", "R-SPO-1483191:r:Synthesis of PC"], "type": "Domain"}, "IPR031316": {"description": "Anti-sigma-28 factor FlgM, C-terminal", "go_ids": [], "go_terms": [], "name": "FlgM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031317": {"description": "Tom37, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tom37_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031318": {"description": "OPI10 family", "go_ids": [], "go_terms": [], "name": "OPI10", "pathway_ids": ["R-SCE-3371453", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-DME-3371453", "R-DDI-3371453", "R-BTA-3371453", "R-XTR-3371453", "R-DRE-3371453", "R-MMU-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DDI-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Family"}, "IPR031319": {"description": "Alpha-amylase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "A-amylase_C", "pathway_ids": ["R-HSA-189085", "R-RNO-189085", "R-HSA-9925561", "R-MMU-189085", "R-DME-189085"], "pathways": ["R-HSA-189085:r:Digestion of dietary carbohydrate", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-DME-189085:r:Digestion of dietary carbohydrate"], "type": "Domain"}, "IPR031320": {"description": "GAGE", "go_ids": [], "go_terms": [], "name": "GAGE", "pathway_ids": ["R-HSA-5601884"], "pathways": ["R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis"], "type": "Domain"}, "IPR031321": {"description": "Uncharacterised conserved protein UCP012641, putative zinc-binding metallo-peptidase", "go_ids": [], "go_terms": [], "name": "UCP012641", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031322": {"description": "Shikimate kinase/gluconokinase", "go_ids": [], "go_terms": [], "name": "Shikimate/glucono_kinase", "pathway_ids": ["PWY-6163", "R-MTU-964903"], "pathways": ["PWY-6163:t:chorismate biosynthesis from 3-dehydroquinate", "R-MTU-964903:r:Chorismate via Shikimate Pathway"], "type": "Family"}, "IPR031325": {"description": "RHS repeat", "go_ids": [], "go_terms": [], "name": "RHS_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR031327": {"description": "Mini-chromosome maintenance protein", "go_ids": ["GO:0003677", "GO:0005524"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F"], "name": "MCM", "pathway_ids": ["R-XTR-69052", "R-RNO-68949", "R-HSA-9825895", "R-GGA-68689", "R-RNO-68962", "R-SPO-68867", "R-HSA-68949", "R-HSA-176974", "R-CEL-68962", "R-XTR-68689", "R-HSA-113507", "R-BTA-68949", "R-MMU-68949", "R-RNO-176187", "R-DME-69052", "R-CEL-68867", "R-BTA-68962", "R-SCE-69052", "R-BTA-176187", "R-DME-68962", "R-DDI-68962", "R-HSA-69052", "R-GGA-68949", "R-HSA-68962", "R-CEL-69052", "R-SCE-176187", "R-SCE-68867", "R-BTA-68689", "R-HSA-176187", "R-BTA-68867", "R-RNO-68689", "R-DME-68949", "R-GGA-68962", "R-HSA-68867", "R-DME-176187", "R-DDI-68867", "R-SPO-176187", "R-MMU-68867", "R-XTR-68962", "R-MMU-68962", "R-BTA-69052", "R-DME-68867", "R-SPO-69052", "R-HSA-68689", "R-SCE-68962", "R-DME-68689", "R-CEL-68949", "R-XTR-68949", "R-XTR-68867", "R-DDI-68949", "R-MMU-176187", "R-DDI-69052", "R-SPO-68962", "R-MMU-68689", "R-SPO-68949", "R-MMU-69052", "R-GGA-176187"], "pathways": ["R-XTR-69052:r:Switching of origins to a post-replicative state", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-GGA-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-SPO-68867:r:Assembly of the pre-replicative complex", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-176974:r:Unwinding of DNA", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-XTR-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-DME-69052:r:Switching of origins to a post-replicative state", "R-CEL-68867:r:Assembly of the pre-replicative complex", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-SCE-69052:r:Switching of origins to a post-replicative state", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-GGA-68949:r:Orc1 removal from chromatin", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-CEL-69052:r:Switching of origins to a post-replicative state", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68867:r:Assembly of the pre-replicative complex", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68949:r:Orc1 removal from chromatin", "R-GGA-68962:r:Activation of the pre-replicative complex", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DDI-68867:r:Assembly of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-BTA-69052:r:Switching of origins to a post-replicative state", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-SPO-69052:r:Switching of origins to a post-replicative state", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-68949:r:Orc1 removal from chromatin", "R-XTR-68949:r:Orc1 removal from chromatin", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-DDI-69052:r:Switching of origins to a post-replicative state", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-68949:r:Orc1 removal from chromatin", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-GGA-176187:r:Activation of ATR in response to replication stress"], "type": "Family"}, "IPR031328": {"description": "Ephrin", "go_ids": [], "go_terms": [], "name": "Ephrin", "pathway_ids": ["R-CEL-3928664", "R-HSA-3928664", "R-MMU-3928665", "R-DRE-3928662", "R-RNO-2682334", "R-MMU-2682334", "R-MMU-3928663", "R-RNO-3928663", "R-RNO-3928664", "R-HSA-3928662", "R-CEL-3928665", "R-DRE-3928664", "R-BTA-3928663", "R-HSA-3928663", "R-CEL-3928663", "R-HSA-3928665", "R-CEL-2682334", "R-RNO-3928665", "R-MMU-3928662", "R-RNO-3928662", "R-BTA-2682334", "R-HSA-2682334", "R-DRE-3928665", "R-DRE-3928663", "R-CEL-3928662", "R-BTA-3928665", "R-MMU-3928664", "R-DRE-2682334"], "pathways": ["R-CEL-3928664:r:Ephrin signaling", "R-HSA-3928664:r:Ephrin signaling", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928664:r:Ephrin signaling", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-BTA-2682334:r:EPH-Ephrin signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-3928664:r:Ephrin signaling", "R-DRE-2682334:r:EPH-Ephrin signaling"], "type": "Family"}, "IPR031329": {"description": "Neutral/alkaline non-lysosomal ceramidase, N-terminal", "go_ids": [], "go_terms": [], "name": "NEUT/ALK_ceramidase_N", "pathway_ids": 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"R-DDI-2022857", "R-HSA-4085001", "R-DDI-2024101", "R-HSA-2206308"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-9953111:r:MPS IV - Morquio syndrome B (CS/DS degradation)", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-2022857:r:Keratan sulfate degradation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-RNO-2024101:r:CS/DS degradation", "R-MMU-4085001:r:Sialic acid metabolism", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-4341670:r:Defective NEU1 causes sialidosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-2022857:r:Keratan sulfate degradation", "R-HSA-4085001:r:Sialic acid metabolism", "R-DDI-2024101:r:CS/DS degradation", "R-HSA-2206308:r:MPS IV - Morquio syndrome B (Keratin metabolism)"], "type": "Domain"}, "IPR031331": {"description": "Neutral/alkaline non-lysosomal ceramidase, C-terminal", "go_ids": [], "go_terms": [], "name": "NEUT/ALK_ceramidase_C", "pathway_ids": ["PWY-6483", "PWY-7119", "R-DDI-9840310", "R-MMU-9840310", "R-RNO-9840310", "R-DME-9840310", "R-DRE-9840310", "R-HSA-9840310"], "pathways": ["PWY-6483:t:ceramide degradation (generic)", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-DME-9840310:r:Glycosphingolipid catabolism", "R-DRE-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Domain"}, "IPR031333": {"description": "Daxx, N-terminal Rassf1C-interacting domain", "go_ids": [], "go_terms": [], "name": "Daxx_N", "pathway_ids": ["R-RNO-6804757", "R-MMU-3899300", 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centromeric region:C"], "name": "Kre28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031362": {"description": "Protein BNIP5", "go_ids": [], "go_terms": [], "name": "BNIP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031363": {"description": "Transmembrane protein 252", "go_ids": [], "go_terms": [], "name": "TMEM252", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031364": {"description": "Germinal centre-associated lymphoma protein", "go_ids": ["GO:0050855", "GO:2000401"], "go_terms": ["GO:0050855:regulation of B cell receptor signaling pathway:P", "GO:2000401:regulation of lymphocyte migration:P"], "name": "GC_assoc_lym", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031365": {"description": "Ciliary microtubule inner protein 6", "go_ids": [], "go_terms": [], "name": "CMIP6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031366": {"description": "Protein of unknown function DUF4663", "go_ids": [], "go_terms": [], "name": "DUF4663", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031367": {"description": "Coiled-coil domain-containing protein 24", "go_ids": [], "go_terms": [], "name": "CCDC24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031368": {"description": "Spermatid maturation protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "SPEM1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031369": {"description": "Proline-rich protein 18", "go_ids": [], "go_terms": [], "name": "PRR18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031370": {"description": "Altered inheritance of mitochondria protein 3", "go_ids": ["GO:0030479", "GO:0051016"], "go_terms": ["GO:0030479:actin cortical patch:C", "GO:0051016:barbed-end actin filament capping:P"], "name": "Aim3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031371": {"description": "Cell-membrane associated Mucin-15", "go_ids": [], "go_terms": [], "name": "Mucin-15", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-MMU-913709", "R-HSA-5083625", "R-HSA-977068", "R-MMU-977068", "R-HSA-5621480", "R-HSA-913709"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Family"}, "IPR031372": {"description": "CAMSAP, spectrin and Ca2+/calmodulin-binding region", "go_ids": ["GO:0031175", "GO:0030507", "GO:0005516"], "go_terms": ["GO:0031175:neuron projection development:P", "GO:0030507:spectrin binding:F", "GO:0005516:calmodulin binding:F"], "name": "CAMSAP_CC1", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR031373": {"description": "Circadian-associated transcriptional repressor", "go_ids": ["GO:0032922", "GO:0000976"], "go_terms": ["GO:0032922:circadian regulation of gene expression:P", "GO:0000976:transcription cis-regulatory region binding:F"], "name": "Ciart", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031374": {"description": "Uncharacterised protein family UPF0715", "go_ids": [], "go_terms": [], "name": "UPF0715", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031375": {"description": "Penicillin-binding protein, N-terminal", "go_ids": [], "go_terms": [], "name": "PBP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031376": {"description": "Penicillin-binding protein, OB-like domain", "go_ids": [], "go_terms": [], "name": "PCB_OB", "pathway_ids": ["PWY-6471", "PWY-5265"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)"], "type": "Domain"}, "IPR031377": {"description": "Inovirus G7P protein", "go_ids": [], "go_terms": [], "name": "Tail_VII", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031378": {"description": "Small vasohibin-binding protein", "go_ids": [], "go_terms": [], "name": "SVBP", "pathway_ids": ["R-HSA-8955332"], "pathways": ["R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Family"}, "IPR031379": {"description": "CLLAC-motif containing domain", "go_ids": [], "go_terms": [], "name": "CLLAC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031380": {"description": "Six6 opposite strand transcript 1", "go_ids": [], "go_terms": [], "name": "SIX6OS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031381": {"description": "YtcA family", "go_ids": [], "go_terms": [], "name": "YtcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031382": {"description": "Uncharacterised protein YjbT", "go_ids": [], "go_terms": [], "name": "YjbT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031383": {"description": "Uncharacterised protein ycf90", "go_ids": [], "go_terms": [], "name": "Ycf90", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031384": {"description": "Herpesvirus US34A", "go_ids": [], "go_terms": [], "name": "HHV-5_US34A", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR031385": {"description": "Small capsid protein, Herpesviridae", "go_ids": [], "go_terms": [], "name": "HV_small_capsid", "pathway_ids": ["R-HSA-9609690", "R-HSA-9610379"], "pathways": ["R-HSA-9609690:r:HCMV Early Events", "R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR031386": {"description": "Unique cartilage matrix-associated protein", "go_ids": ["GO:0045667"], "go_terms": ["GO:0045667:regulation of osteoblast differentiation:P"], "name": "UCMA", "pathway_ids": ["R-HSA-8940973"], "pathways": ["R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation"], "type": "Family"}, "IPR031387": {"description": "Spindle and centriole-associated protein 1", "go_ids": ["GO:0090307"], "go_terms": ["GO:0090307:mitotic spindle assembly:P"], "name": "SPICE1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031388": {"description": "Topoisomerase I damage affected protein 11", "go_ids": [], "go_terms": [], "name": "Tda11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031389": {"description": "Ribosomal biogenesis factor", "go_ids": ["GO:0042254"], "go_terms": ["GO:0042254:ribosome biogenesis:P"], "name": "RBIS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031390": {"description": "Orofacial cleft 1 candidate gene 1 protein", "go_ids": [], "go_terms": [], "name": "OFCC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031391": {"description": "Nucleolar protein Swm2", "go_ids": [], "go_terms": [], "name": "Swm2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031392": {"description": "Spindle pole component 29", "go_ids": ["GO:0030474", "GO:0005200", "GO:0005823"], "go_terms": ["GO:0030474:spindle pole body duplication:P", "GO:0005200:structural constituent of cytoskeleton:F", "GO:0005823:central plaque of spindle pole body:C"], "name": "Spc29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031393": {"description": "Lymphocyte transmembrane adapter 1", "go_ids": ["GO:0006955", "GO:0051249"], "go_terms": ["GO:0006955:immune response:P", "GO:0051249:regulation of lymphocyte activation:P"], "name": "LAX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031394": {"description": "Musculoskeletal embryonic nuclear protein 1", "go_ids": ["GO:0042246", "GO:0002062", "GO:0035988", "GO:0005634"], "go_terms": ["GO:0042246:tissue regeneration:P", "GO:0002062:chondrocyte differentiation:P", "GO:0035988:chondrocyte proliferation:P", "GO:0005634:nucleus:C"], "name": "MUSTN1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031395": {"description": "Protein Sop4", "go_ids": [], "go_terms": [], "name": "Sop4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031396": {"description": "Multidrug resistance efflux pump SepA", "go_ids": [], "go_terms": [], "name": "SepA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031397": {"description": "Male-specific protein scotti", "go_ids": ["GO:0007291"], "go_terms": ["GO:0007291:sperm individualization:P"], "name": "Soti", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031398": {"description": "SWI5-dependent HO expression protein 3", "go_ids": ["GO:0048309", "GO:0051028"], "go_terms": ["GO:0048309:endoplasmic reticulum inheritance:P", "GO:0051028:mRNA transport:P"], "name": "She3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031399": {"description": "Testis development-related protein", "go_ids": ["GO:0007283"], "go_terms": ["GO:0007283:spermatogenesis:P"], "name": "TDRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031400": {"description": "Gametogenetin", "go_ids": ["GO:0007276", "GO:0006302"], "go_terms": ["GO:0007276:gamete generation:P", "GO:0006302:double-strand break repair:P"], "name": "GGN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031401": {"description": "She1", "go_ids": ["GO:0008017", "GO:0015630"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0015630:microtubule cytoskeleton:C"], "name": "She1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031402": {"description": "Protein LYRIC", "go_ids": ["GO:0043123", "GO:0043066", "GO:0045766"], "go_terms": ["GO:0043123:positive regulation of canonical NF-kappaB signal transduction:P", "GO:0043066:negative regulation of apoptotic process:P", "GO:0045766:positive regulation of angiogenesis:P"], "name": "LYRIC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031403": {"description": "Sbe2/Sbe22, C-terminal domain", "go_ids": ["GO:0031505"], "go_terms": ["GO:0031505:fungal-type cell wall organization:P"], "name": "Sbe2/Sbe22_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031404": {"description": "Regulator of rDNA transcription 14", "go_ids": [], "go_terms": [], "name": "Rrt14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031405": {"description": "Nuclear receptor-interacting protein 1, repression domain 1", "go_ids": [], "go_terms": [], "name": "NRIP1_RD1", "pathway_ids": ["R-HSA-9029558", "R-MMU-3899300", "R-HSA-9933387", "R-HSA-9632974", "R-HSA-9707616", "R-HSA-3899300", "R-HSA-9018519", "R-HSA-9931509", "R-MMU-9018519"], "pathways": ["R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-HSA-9707616:r:Heme signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR031406": {"description": "Nuclear receptor-interacting protein 1, repression domain 2", "go_ids": [], "go_terms": [], "name": "NRIP1_RD2", "pathway_ids": ["R-HSA-9029558", "R-MMU-3899300", "R-HSA-9933387", "R-HSA-9632974", "R-HSA-9707616", "R-HSA-3899300", "R-HSA-9018519", "R-HSA-9931509", "R-MMU-9018519"], "pathways": ["R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-HSA-9707616:r:Heme signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR031407": {"description": "Nuclear receptor-interacting protein 1, repression domain 3", "go_ids": [], "go_terms": [], "name": "NRIP1_RD3", "pathway_ids": ["R-HSA-9029558", "R-MMU-3899300", "R-HSA-9933387", "R-HSA-9632974", "R-HSA-9707616", "R-HSA-3899300", "R-HSA-9018519", "R-HSA-9931509", "R-MMU-9018519"], "pathways": ["R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-HSA-9707616:r:Heme signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Family"}, "IPR031408": {"description": "Nuclear receptor-interacting protein 1, repression domain 4", "go_ids": [], "go_terms": [], "name": "NRIP1_RD4", "pathway_ids": ["R-HSA-9029558", "R-MMU-3899300", "R-HSA-9933387", "R-HSA-9632974", "R-HSA-9707616", "R-HSA-3899300", "R-HSA-9018519", "R-HSA-9931509", "R-MMU-9018519"], "pathways": ["R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-HSA-9707616:r:Heme signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR031409": {"description": "Darcynin", "go_ids": [], "go_terms": [], "name": "Darcynin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031410": {"description": "Stabilizer of axonemal microtubules 4", "go_ids": [], "go_terms": [], "name": "SAXO4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031411": {"description": "Two-component-system connector protein SafA", "go_ids": [], "go_terms": [], "name": "SafA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031412": {"description": "Torovirinae spike protein", "go_ids": [], "go_terms": [], "name": "S_torovirinae", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031413": {"description": "Outer capsid protein VP7", "go_ids": [], "go_terms": [], "name": "Capsid_VP7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031414": {"description": "Small ribosomal subunit protein bTHX", "go_ids": ["GO:0005840"], "go_terms": ["GO:0005840:ribosome:C"], "name": "Ribosomal_bTHX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031415": {"description": "Required for respiratory growth protein 8, mitochondrial", "go_ids": ["GO:0097745"], "go_terms": ["GO:0097745:mitochondrial tRNA 5'-end processing:P"], "name": "Rrg8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031416": {"description": "Mediator complex subunit 26, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Med26_C", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR031417": {"description": "Mediator complex subunit 26, middle domain", "go_ids": [], "go_terms": [], "name": "Med26_Mid", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR031418": {"description": "RBPJ-interacting and tubulin-associated protein 1", "go_ids": ["GO:0015631", "GO:0007219", "GO:0051168"], "go_terms": ["GO:0015631:tubulin binding:F", "GO:0007219:Notch signaling pathway:P", "GO:0051168:nuclear export:P"], "name": "RITA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031419": {"description": "RAD51 interacting motif", "go_ids": [], "go_terms": [], "name": "RAD51_interact", "pathway_ids": ["R-HSA-5685942", "R-HSA-9704331", "R-HSA-5693579", "R-HSA-9704646", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5685942", "R-MMU-5693579", "R-HSA-9709603", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR031420": {"description": "UPF0669 protein C6orf120", "go_ids": [], "go_terms": [], "name": "UPF0669", "pathway_ids": ["R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-XTR-6798695", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR031421": {"description": "Protein of unknown function DUF4666", "go_ids": [], "go_terms": [], "name": "DUF4666", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031423": {"description": "Phosphatase SCO2771", "go_ids": [], "go_terms": [], "name": "Phosphatase_SCO2771", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031424": {"description": "UPAR/Ly6 domain-containing protein Quiver-like", "go_ids": ["GO:0030431", "GO:0032222", "GO:1903818"], "go_terms": ["GO:0030431:sleep:P", "GO:0032222:regulation of synaptic transmission, cholinergic:P", "GO:1903818:positive regulation of voltage-gated potassium channel activity:P"], "name": "QVR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031425": {"description": "NPR1/NH1-interacting protein", "go_ids": ["GO:0010112"], "go_terms": ["GO:0010112:regulation of systemic acquired resistance:P"], "name": "NPR1/NH1-interacting", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031426": {"description": "Protein of unknown function DUF4667", "go_ids": [], "go_terms": [], "name": "DUF4667", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031427": {"description": "Protein of unknown function DUF4668", "go_ids": [], "go_terms": [], "name": "DUF4668", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031428": {"description": "Linker for activation of T-cells family member 2", "go_ids": ["GO:0042113", "GO:0002764"], "go_terms": ["GO:0042113:B cell activation:P", "GO:0002764:immune response-regulating signaling pathway:P"], "name": "LAT2", "pathway_ids": ["R-HSA-2730905", "R-RNO-2730905", "R-MMU-2730905"], "pathways": ["R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization"], "type": "Family"}, "IPR031429": {"description": "Phenol-soluble modulin alpha peptide", "go_ids": [], "go_terms": [], "name": "PSM_alpha", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031430": {"description": "Outer spore wall protein 5", "go_ids": [], "go_terms": [], "name": "Osw5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031431": {"description": "Prostate androgen-regulated mucin-like protein 1", "go_ids": [], "go_terms": [], "name": "PARM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031432": {"description": "MALE GAMETOPHYTE DEFECTIVE 1", "go_ids": ["GO:0009555"], "go_terms": ["GO:0009555:pollen development:P"], "name": "MGP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031433": {"description": "Monopolar spindle protein 2", "go_ids": ["GO:0030474", "GO:0071988"], "go_terms": ["GO:0030474:spindle pole body duplication:P", "GO:0071988:protein localization to spindle pole body:P"], "name": "Mps2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031434": {"description": "MgtA leader peptide", "go_ids": [], "go_terms": [], "name": "MGTL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031435": {"description": "Transmembrane protein TMEM132, N-terminal", "go_ids": [], "go_terms": [], "name": "TMEM132_N", "pathway_ids": ["R-RNO-381426", "R-MMU-381426", "R-HSA-8957275", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426", "R-DRE-8957275", "R-DRE-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR031436": {"description": "Transmembrane protein TMEM132, C-terminal", "go_ids": [], "go_terms": [], "name": "TMEM132_C", "pathway_ids": ["R-RNO-381426", "R-MMU-381426", "R-HSA-8957275", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426", "R-DRE-8957275", "R-DRE-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR031437": {"description": "Transmembrane protein family 132, fourth domain", "go_ids": [], "go_terms": [], "name": "Ig_TMEM132_4th", "pathway_ids": ["R-RNO-381426", "R-RNO-8957275", "R-MMU-381426", "R-DRE-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-DRE-8957275"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8957275:r:Post-translational protein phosphorylation"], "type": "Domain"}, "IPR031438": {"description": "Mitochondrial coiled-coil domain protein 1", "go_ids": [], "go_terms": [], "name": "MCCD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031439": {"description": "Proline-rich protein family 20", "go_ids": [], "go_terms": [], "name": "PRR20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031440": {"description": "Protein of unknown function DUF4670", "go_ids": [], "go_terms": [], "name": "DUF4670", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031441": {"description": "Break repair meiotic recombinase recruitment factor 1", "go_ids": ["GO:1990918"], "go_terms": ["GO:1990918:double-strand break repair involved in meiotic recombination:P"], "name": "Brme1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031442": {"description": "Protein NPAT, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NPAT_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031443": {"description": "Mitochondrial biogenesis regulation protein 1", "go_ids": [], "go_terms": [], "name": "Mbr1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031444": {"description": "PCNA-associated factor, histone-like domain", "go_ids": [], "go_terms": [], "name": "PCNA-AF_dom", "pathway_ids": ["R-MMU-5656169", "R-BTA-5656169", "R-XTR-5656169", "R-RNO-5656169", "R-HSA-5656169"], "pathways": ["R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-XTR-5656169:r:Termination of translesion DNA synthesis", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656169:r:Termination of translesion DNA synthesis"], "type": "Domain"}, "IPR031445": {"description": "Protein of unknown function DUF4672", "go_ids": [], "go_terms": [], "name": "DUF4672", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031446": {"description": "Pericentriolar material 1 protein, C-terminal", "go_ids": [], "go_terms": [], "name": "PCM1_C", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-2565942", "R-MMU-8854518", "R-HSA-380284", "R-MMU-380270", "R-MMU-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR031447": {"description": "Protein moonraker", "go_ids": ["GO:0007099"], "go_terms": ["GO:0007099:centriole replication:P"], "name": "MNR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031449": {"description": "Annexin-2 receptor", "go_ids": ["GO:0038023"], "go_terms": ["GO:0038023:signaling receptor activity:F"], "name": "ANXA2R", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031450": {"description": "Poxin-Schlafen/Schlafen-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Poxin-SLFN/SLFN_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031451": {"description": "mRNA interferase toxin MqsR", "go_ids": ["GO:0009372", "GO:0017148", "GO:0044010"], "go_terms": ["GO:0009372:quorum sensing:P", "GO:0017148:negative regulation of translation:P", "GO:0044010:single-species biofilm formation:P"], "name": "MqsR_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031452": {"description": "Protein Kre1", "go_ids": ["GO:0031505"], "go_terms": ["GO:0031505:fungal-type cell wall organization:P"], "name": "Kre1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031453": {"description": "Transmembrane protein 119", "go_ids": ["GO:0001503"], "go_terms": ["GO:0001503:ossification:P"], "name": "TMEM119", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031454": {"description": "Viral matrix protein M", "go_ids": [], "go_terms": [], "name": "Viral_M", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031455": {"description": "Genetic interactor of prohibitin 5", "go_ids": ["GO:0097745"], "go_terms": ["GO:0097745:mitochondrial tRNA 5'-end processing:P"], "name": "Gep5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031456": {"description": "Cap-associated protein Caf20", "go_ids": ["GO:0006413", "GO:0017148", "GO:0008190"], "go_terms": ["GO:0006413:translational initiation:P", "GO:0017148:negative regulation of translation:P", "GO:0008190:eukaryotic initiation factor 4E binding:F"], "name": "Caf20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031457": {"description": "Renal cancer differentiation gene 1 protein", "go_ids": [], "go_terms": [], "name": "RCDG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031458": {"description": "Protein of unknown function DUF4677", "go_ids": [], "go_terms": [], "name": "DUF4677", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031459": {"description": "Cytochrome c oxidase assembly factor 2", "go_ids": ["GO:0033617"], "go_terms": ["GO:0033617:mitochondrial respiratory chain complex IV assembly:P"], "name": "Coa2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031460": {"description": "Protein of unknown function DUF4678", "go_ids": [], "go_terms": [], "name": "DUF4678", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031461": {"description": "Protein of unknown function DUF4679", "go_ids": [], "go_terms": [], "name": "DUF4679", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031462": {"description": "Cation channel sperm-associated targeting subunit tau", "go_ids": [], "go_terms": [], "name": "CTSRT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031463": {"description": "MICOS complex subunit Mic12", "go_ids": ["GO:0042407", "GO:0061617", "GO:0044284"], "go_terms": ["GO:0042407:cristae formation:P", "GO:0061617:MICOS complex:C", "GO:0044284:mitochondrial crista junction:C"], "name": "Mic12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031464": {"description": "Protein of unknown function DUF4680", "go_ids": [], "go_terms": [], "name": "DUF4680", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031465": {"description": "Protein of unknown function DUF4681", "go_ids": [], "go_terms": [], "name": "DUF4681", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031466": {"description": "Migration and invasion-inhibitory protein", "go_ids": ["GO:0030336", "GO:0010972"], "go_terms": ["GO:0030336:negative regulation of cell migration:P", "GO:0010972:negative regulation of G2/M transition of mitotic cell cycle:P"], "name": "MIIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031467": {"description": "ATPase expression protein 1", "go_ids": ["GO:0045182", "GO:0006417"], "go_terms": ["GO:0045182:translation regulator activity:F", "GO:0006417:regulation of translation:P"], "name": "Aep1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031469": {"description": "Fungal death-pathway protein, SesB domain", "go_ids": [], "go_terms": [], "name": "SesB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031470": {"description": "CEP63/Deup1, N-terminal", "go_ids": [], "go_terms": [], "name": "CEP63/Deup1_N", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-MMU-380270", "R-DRE-380320", "R-HSA-380284", "R-HSA-380270", "R-RNO-5620912", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-RNO-380320", "R-RNO-380259", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR031471": {"description": "Protein BptA", "go_ids": [], "go_terms": [], "name": "BptA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031472": {"description": "MAT1-1-2/MatA-2/Smr1", "go_ids": [], "go_terms": [], "name": "MAT1-1-2/MatA-2/Smr1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031473": {"description": "Protein of unknown function DUF4684", "go_ids": [], "go_terms": [], "name": "DUF4684", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031474": {"description": "Protein phosphatase 1 regulatory subunit 26, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PPP1R26_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031475": {"description": "Four-carbon acid sugar kinase, nucleotide binding domain", "go_ids": [], "go_terms": [], "name": "NBD_C", "pathway_ids": ["PWY-7873", "PWY-7874"], "pathways": ["PWY-7873:t:D-erythronate degradation II", "PWY-7874:t:L-threonate degradation"], "type": "Domain"}, "IPR031476": {"description": "Protein of unknown function DUF4686", "go_ids": [], "go_terms": [], "name": "DUF4686", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031477": {"description": "E domain", "go_ids": [], "go_terms": [], "name": "SasG_E", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031478": {"description": "Spermatogenesis-associated protein 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SPATA1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031479": {"description": "Protein SLX4IP", "go_ids": [], "go_terms": [], "name": "SLX4IP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031480": {"description": "Cellulose-complementing protein", "go_ids": [], "go_terms": [], "name": "CcpAX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031481": {"description": "Fucosyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "Glyco_tran_10_N", "pathway_ids": ["R-DRE-5173105", "R-RNO-9037629", "R-HSA-975578", "R-DME-975578", "R-HSA-9037629", "R-RNO-5173105", "R-CFA-9037629", "R-CFA-5173105", "R-BTA-9037629", "R-DME-9037629", "R-MMU-5173105", "R-CEL-9037629", "R-MMU-9037629", "R-HSA-5173105", "R-CEL-975578"], "pathways": ["R-DRE-5173105:r:O-linked glycosylation", "R-RNO-9037629:r:Lewis blood group biosynthesis", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-RNO-5173105:r:O-linked glycosylation", "R-CFA-9037629:r:Lewis blood group biosynthesis", "R-CFA-5173105:r:O-linked glycosylation", "R-BTA-9037629:r:Lewis blood group biosynthesis", "R-DME-9037629:r:Lewis blood group biosynthesis", "R-MMU-5173105:r:O-linked glycosylation", "R-CEL-9037629:r:Lewis blood group biosynthesis", "R-MMU-9037629:r:Lewis blood group biosynthesis", "R-HSA-5173105:r:O-linked glycosylation", "R-CEL-975578:r:Reactions specific to the complex N-glycan synthesis pathway"], "type": "Domain"}, "IPR031482": {"description": "Cellulose biosynthesis protein BcsN", "go_ids": [], "go_terms": [], "name": "CBP_BcsN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031483": {"description": "AP-1 complex-associated regulatory protein", "go_ids": ["GO:2000146", "GO:0034315", "GO:0035650", "GO:1900025", "GO:0006895"], "go_terms": ["GO:2000146:negative regulation of cell motility:P", "GO:0034315:regulation of Arp2/3 complex-mediated actin nucleation:P", "GO:0035650:AP-1 adaptor complex binding:F", "GO:1900025:negative regulation of substrate adhesion-dependent cell spreading:P", "GO:0006895:Golgi to endosome transport:P"], "name": "AP1AR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031484": {"description": "Cellulose biosynthesis protein BcsO", "go_ids": [], "go_terms": [], "name": "CBP_BcsO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031485": {"description": "Cellulose biosynthesis protein BcsS", "go_ids": [], "go_terms": [], "name": "CBP_BcsS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031486": {"description": "Transmembrane protein 215", "go_ids": [], "go_terms": [], "name": "TMEM215", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031487": {"description": "Protein of unknown function DUF4687", "go_ids": [], "go_terms": [], "name": "DUF4687", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031488": {"description": "GATOR2 complex protein MIO, zinc-ribbon like domain", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_mio", "pathway_ids": ["R-MMU-9639288", "R-DDI-9639288", "R-HSA-9639288", "R-DRE-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DRE-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR031489": {"description": "D,L-carboxypeptidase, peptidase domain", "go_ids": [], "go_terms": [], "name": "Peptidase_M99", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031490": {"description": "FAAP20, zinc finger UBZ2-type", "go_ids": ["GO:0043130"], "go_terms": ["GO:0043130:ubiquitin binding:F"], "name": "UBZ2_FAAP20", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-RNO-9833482", "R-RNO-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR031491": {"description": "FAAP20, FANCA interaction domain", "go_ids": [], "go_terms": [], "name": "FANCA_interact", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-RNO-9833482", "R-RNO-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR031492": {"description": "Protein of unknown function DUF5101", "go_ids": [], "go_terms": [], "name": "DUF5101", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031493": {"description": "Zinc-ribbon 15", "go_ids": [], "go_terms": [], "name": "Zinc_ribbon_15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031494": {"description": "Putative beta-lactamase-like family", "go_ids": [], "go_terms": [], "name": "Beta_lactamase3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031495": {"description": "Protein of unknown function DUF5100", "go_ids": [], "go_terms": [], "name": "DUF5100", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031496": {"description": "Protein of unknown function DUF4688", "go_ids": [], "go_terms": [], "name": "DUF4688", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031497": {"description": "Microsporidial 8TM transmembrane domain", "go_ids": [], "go_terms": [], "name": "8TM_micro", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031498": {"description": "Bromodomain associated protein-like", "go_ids": [], "go_terms": [], "name": "Bromo_TP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031499": {"description": "Protein of unknown function DUF4689", "go_ids": [], "go_terms": [], "name": "DUF4689", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031500": {"description": "Protein SNORC", "go_ids": ["GO:0051216"], "go_terms": ["GO:0051216:cartilage development:P"], "name": "SNORC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031501": {"description": "Amelotin", "go_ids": ["GO:0070175", "GO:0042475"], "go_terms": ["GO:0070175:positive regulation of enamel mineralization:P", "GO:0042475:odontogenesis of dentin-containing tooth:P"], "name": "Amelotin", "pathway_ids": ["R-RNO-381426", "R-MMU-381426", "R-HSA-8957275", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR031502": {"description": "Putative zinc-finger ribonucleoprotein", "go_ids": [], "go_terms": [], "name": "Zf_ribonucleo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031503": {"description": "Protein of unknown function DUF5099", "go_ids": [], "go_terms": [], "name": "DUF5099", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031504": {"description": "Putative DMAP1-like", "go_ids": [], "go_terms": [], "name": "DMAP1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031505": {"description": "Protein of unknown function DUF5098", "go_ids": [], "go_terms": [], "name": "DUF5098", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031506": {"description": "Histidine-rich carboxyl terminus protein 1", "go_ids": [], "go_terms": [], "name": "HRCT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031507": {"description": "Polar tube protein 2", "go_ids": [], "go_terms": [], "name": "PTP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031508": {"description": "Transmembrane protein 108", "go_ids": [], "go_terms": [], "name": "TMEM108", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031509": {"description": "Putative double-strand recombination repair protein-like", "go_ids": [], "go_terms": [], "name": "Mei5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031510": {"description": "Leukemia-associated protein 7", "go_ids": [], "go_terms": [], "name": "DLEU7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031511": {"description": "Domain of unknown function DUF5097", "go_ids": [], "go_terms": [], "name": "DUF5097", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031512": {"description": "Domain of unknown function DUF5096", "go_ids": [], "go_terms": [], "name": "DUF5096", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031513": {"description": "Spore wall protein", "go_ids": [], "go_terms": [], "name": "MICSWaP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031514": {"description": "Aberrant zinc-finger domain", "go_ids": [], "go_terms": [], "name": "Zf-C2H2_aberr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031515": {"description": "Protein of unknown function DUF5095", "go_ids": [], "go_terms": [], "name": "DUF5095", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031516": {"description": "Protein of unknown function DUF4691", "go_ids": [], "go_terms": [], "name": "DUF4691", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031517": {"description": "RHEX-like", "go_ids": [], "go_terms": [], "name": "RHEX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031518": {"description": "Protein of unknown function DUF4693", "go_ids": [], "go_terms": [], "name": "DUF4693", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031519": {"description": "Domain of unknown function DUF5094", "go_ids": [], "go_terms": [], "name": "DUF5094", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031520": {"description": "Protein of unknown function DUF4694", "go_ids": [], "go_terms": [], "name": "DUF4694", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031521": {"description": "Protein of unknown function DUF4695", "go_ids": [], "go_terms": [], "name": "DUF4695", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031522": {"description": "Putative Mad3/Bub1 like region 1 protein", "go_ids": [], "go_terms": [], "name": "Mad3_Bub1_I_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031523": {"description": "Putative acetyl-transferase", "go_ids": [], "go_terms": [], "name": "Acetyltransf_15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031524": {"description": "Armadillo-like helical domain-containing protein 4", "go_ids": [], "go_terms": [], "name": "ARMH4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031525": {"description": "Coiled-coil domain-containing protein 190", "go_ids": [], "go_terms": [], "name": "CC190", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031526": {"description": "Protein of unknown function DUF4698", "go_ids": [], "go_terms": [], "name": "DUF4698", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031527": {"description": "Protein of unknown function DUF5091", "go_ids": [], "go_terms": [], "name": "DUF5091", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031528": {"description": "PDCD10 and GCKIII kinases-associated protein 1 C4orf19/PGCKA1", "go_ids": [], "go_terms": [], "name": "C4orf19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031529": {"description": "Interactor of HORMAD1 protein 1", "go_ids": ["GO:0006310", "GO:0042138"], "go_terms": ["GO:0006310:DNA recombination:P", "GO:0042138:meiotic DNA double-strand break formation:P"], "name": "IHO1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031530": {"description": "UPF0688 family", "go_ids": [], "go_terms": [], "name": "UPF0688", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031531": {"description": "Dynein axonemal assembly factor 8", "go_ids": ["GO:0070840"], "go_terms": ["GO:0070840:dynein complex binding:F"], "name": "DNAAF8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031532": {"description": "Protein of unknown function DUF4702", "go_ids": [], "go_terms": [], "name": "DUF4702", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031533": {"description": "Protein of unknown function DUF5093", "go_ids": [], "go_terms": [], "name": "DUF5093", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031534": {"description": "Sperm acrosome developmental regulator", "go_ids": [], "go_terms": [], "name": "SPACDR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031535": {"description": "Proline-rich protein 22", "go_ids": [], "go_terms": [], "name": "PRR22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031537": {"description": "Protein of unknown function DUF5092", "go_ids": [], "go_terms": [], "name": "DUF5092", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031538": {"description": "Tryptophan RNA-binding attenuator protein inhibitory protein", "go_ids": [], "go_terms": [], "name": "Anti-TRAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031539": {"description": "Protein of unknown function DUF5090", "go_ids": [], "go_terms": [], "name": "DUF5090", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031540": {"description": "Protein of unknown function DUF5088", "go_ids": [], "go_terms": [], "name": "DUF5088", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031541": {"description": "HTH-like domain-containing protein, Microsporidia", "go_ids": [], "go_terms": [], "name": "HTH_micro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031542": {"description": "Cation channel complex component UNC80, N-terminal", "go_ids": [], "go_terms": [], "name": "UNC80_N", "pathway_ids": ["R-MMU-2672351", "R-HSA-2672351", "R-DME-2672351"], "pathways": ["R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-DME-2672351:r:Stimuli-sensing channels"], "type": "Domain"}, "IPR031543": {"description": "Protein of unknown function DUF5087", "go_ids": [], "go_terms": [], "name": "DUF5087", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031544": {"description": "WD40-like domain containing protein", "go_ids": [], "go_terms": [], "name": "WD40-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031545": {"description": "Signal recognition particle subunit SRP72, TPR-like repeat", "go_ids": [], "go_terms": [], "name": "SRP72_TPR-like", "pathway_ids": ["R-HSA-1799339", "R-CFA-1799339", "R-CEL-1799339", "R-DDI-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Repeat"}, "IPR031546": {"description": "Putative actin-like", "go_ids": [], "go_terms": [], "name": "Actin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031547": {"description": "Protein of unknown function DUF5089", "go_ids": [], "go_terms": [], "name": "DUF5089", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031548": {"description": "Accessory secretory protein Asp5", "go_ids": [], "go_terms": [], "name": "Asp5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031549": {"description": "Abnormal spindle-like microcephaly-associated protein, ASH domain", "go_ids": [], "go_terms": [], "name": "ASH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031550": {"description": "Rad61, Wapl domain", "go_ids": [], "go_terms": [], "name": "Rad61_Wapl", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031551": {"description": "Accessory secretory protein Asp4", "go_ids": [], "go_terms": [], "name": "Asp4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031552": {"description": "ParE-like toxin", "go_ids": [], "go_terms": [], "name": "ParE-like_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031553": {"description": "Lysyl-tRNA synthetase, N-terminal transmembrane region", "go_ids": [], "go_terms": [], "name": "tRNA-synt_2_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031554": {"description": "Fibrous sheath-interacting protein 2, C-terminal", "go_ids": [], "go_terms": [], "name": "FSIP2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031555": {"description": "DNA-directed RNA polymerase subunit Rpo8", "go_ids": [], "go_terms": [], "name": "RNA_pol_Rpo8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031556": {"description": "Sir4, SID domain", "go_ids": [], "go_terms": [], "name": "SIR4_SID", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031557": {"description": "N-CoR, GPS2-interacting domain", "go_ids": [], "go_terms": [], "name": "N-CoR_GPS2_interact", "pathway_ids": ["R-MMU-2173795", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-9022692", "R-HSA-1251985", "R-HSA-9841922", "R-MMU-383280", "R-HSA-2173795", "R-HSA-9707564", "R-HSA-9933387", "R-MMU-9841922", "R-MMU-400206", "R-HSA-9029569", "R-MMU-9029569", "R-HSA-2122947", "R-HSA-9931509", "R-HSA-5617472", "R-MMU-9623433", "R-HSA-9022537", "R-HSA-381340", "R-HSA-2894862", "R-HSA-9707616", "R-HSA-3214815", "R-HSA-9609690", "R-HSA-350054", "R-HSA-383280", "R-MMU-381340", "R-MMU-350054", "R-HSA-400206", "R-HSA-2644606", "R-HSA-3899300", "R-HSA-9623433", "R-MMU-9707564"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-HSA-9022537:r:Loss of MECP2 binding ability to the NCoR/SMRT complex", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9707616:r:Heme signaling", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR031558": {"description": "Vacuolar protein-sorting-associated protein 36, NZF-N zinc-finger domain", "go_ids": [], "go_terms": [], "name": "Vps36-NZF-N", "pathway_ids": ["R-SCE-917729"], "pathways": ["R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Domain"}, "IPR031559": {"description": "Serine/threonine-protein kinase SMG1", "go_ids": ["GO:0016310", "GO:0004674", "GO:0000184"], "go_terms": ["GO:0016310:phosphorylation:P", "GO:0004674:protein serine/threonine kinase activity:F", "GO:0000184:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay:P"], "name": "SMG1", "pathway_ids": ["R-HSA-975957", "R-DRE-975957", "R-MMU-975957"], "pathways": ["R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Family"}, "IPR031560": {"description": "Heavy-metal resistance protein CzcE", "go_ids": [], "go_terms": [], "name": "CzcE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031561": {"description": "Protein of unknown function DUF5086", "go_ids": [], "go_terms": [], "name": "DUF5086", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031563": {"description": "Molybdate transporter 1/2", "go_ids": ["GO:0015689", "GO:0015098"], "go_terms": ["GO:0015689:molybdate ion transport:P", "GO:0015098:molybdate ion transmembrane transporter activity:F"], "name": "MOT1/MOT2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031564": {"description": "Putative Flagellin, Flp1-like domain", "go_ids": [], "go_terms": [], "name": "Flp1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031565": {"description": "T-superfamily conotoxin", "go_ids": ["GO:0090729"], "go_terms": ["GO:0090729:toxin activity:F"], "name": "T-conotoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031566": {"description": "Putative citrate transporter", "go_ids": [], "go_terms": [], "name": "CitMHS_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031567": {"description": "Sin1, middle CRIM domain", "go_ids": [], "go_terms": [], "name": "CRIM_dom", "pathway_ids": ["R-MMU-9856530", "R-RNO-1257604", "R-SPO-389357", "R-SCE-389357", "R-RNO-5218920", "R-DDI-6804757", "R-MMU-389357", "R-HSA-5218920", "R-SCE-6804757", "R-CEL-1257604", "R-CEL-389357", "R-HSA-6804757", "R-GGA-9856530", "R-DDI-5218920", "R-SCE-1257604", "R-HSA-9920951", "R-GGA-5218920", "R-SPO-1257604", "R-SPO-6804757", "R-SCE-9856530", "R-SPO-9856530", "R-GGA-1257604", "R-RNO-389357", "R-DDI-1257604", "R-MMU-5218920", "R-HSA-5674400", "R-MMU-6804757", "R-GGA-6804757", "R-SPO-5218920", "R-MMU-1257604", "R-CEL-6804757", "R-GGA-389357", "R-DME-5218920", "R-RNO-9856530", "R-RNO-6804757", "R-DDI-9856530", "R-DME-1257604", "R-HSA-389357", "R-DDI-389357", "R-HSA-9856530", "R-HSA-1257604", "R-DME-389357", "R-DME-9856530", "R-CEL-5218920", "R-SCE-5218920", "R-CEL-9856530"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-GGA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-GGA-5218920:r:VEGFR2 mediated vascular permeability", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-GGA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-389357:r:CD28 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"Domain"}, "IPR031570": {"description": "Neurobeachin/BDCP, DUF4704", "go_ids": [], "go_terms": [], "name": "NBEA/BDCP_DUF4704", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-DRE-6798695", "R-HSA-2122947", "R-MMU-6798695", "R-HSA-112314", "R-HSA-9609736", "R-HSA-163615"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-163615:r:PKA activation"], "type": "Domain"}, "IPR031571": {"description": "Flp pilus assembly protein RcpC/CpaB domain", "go_ids": [], "go_terms": [], "name": "RcpC_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031572": {"description": "Domain of unknown function DUF4705", 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phototransduction cascade", "R-SCE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-GGA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-XTR-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Domain"}, "IPR031616": {"description": "Small toxic protein BsrE-like", "go_ids": [], "go_terms": [], "name": "BsrE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031617": {"description": "Putative exopolysaccharide exporter", "go_ids": [], "go_terms": [], "name": "PelG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031618": {"description": "Putative type IV secretory system protein", "go_ids": [], "go_terms": [], "name": "T4SS_TraI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031619": {"description": "DNA transfer protein", "go_ids": [], "go_terms": [], "name": "Inj_translocase", "pathway_ids": [], "pathways": [], "type": "Family"}, 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membrane", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-4793954:r:Defective MOGS causes CDG-2b"], "type": "Domain"}, "IPR031632": {"description": "Small VCP/p97-interacting protein", "go_ids": [], "go_terms": [], "name": "SVIP", "pathway_ids": ["R-MMU-6798695", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR031633": {"description": "DNA replication complex GINS protein SLD5, C-terminal", "go_ids": [], "go_terms": [], "name": "SLD5_C", "pathway_ids": ["R-BTA-176974", "R-RNO-176974", "R-SPO-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974"], "pathways": ["R-BTA-176974:r:Unwinding of DNA", "R-RNO-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA"], "type": "Domain"}, "IPR031634": {"description": "Protein kinase G, rubredoxin domain", "go_ids": [], "go_terms": [], "name": "PknG_rubred", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031635": {"description": "Growth factor receptor NTRK, leucine rich repeat C-terminal", "go_ids": [], "go_terms": [], "name": "NTRK_LRRCT", "pathway_ids": ["R-HSA-167044", "R-HSA-187042", "R-HSA-9034015", "R-MMU-6811558", "R-HSA-9026357", "R-RNO-1257604", "R-HSA-167021", "R-HSA-198745", "R-RNO-187042", "R-HSA-9026519", "R-MMU-388844", "R-HSA-9032759", "R-MMU-9034793", "R-MMU-198203", "R-RNO-198203", "R-HSA-388844", "R-RNO-6811558", "R-HSA-9603381", "R-MMU-187042", "R-RNO-177504", "R-RNO-170968", "R-HSA-9028335", "R-GGA-6811558", "R-RNO-9034013", "R-RNO-9026527", "R-RNO-170984", "R-HSA-9032845", "R-HSA-9025046", "R-HSA-9028731", "R-HSA-170984", "R-GGA-1257604", "R-MMU-9034013", "R-HSA-9026527", "R-MMU-9603381", "R-MMU-170968", "R-HSA-9603505", "R-RNO-9034793", "R-RNO-9603381", "R-MMU-9028731", "R-HSA-9034793", "R-HSA-9024909", "R-HSA-9034864", "R-MMU-1257604", "R-HSA-2219530", "R-HSA-9032500", "R-HSA-6811558", "R-HSA-177504", "R-HSA-9034013", "R-RNO-9032759", "R-HSA-187024", "R-HSA-187706", "R-MMU-177504", "R-HSA-170968", "R-MMU-9032759", "R-MMU-170984", "R-RNO-388844", "R-HSA-1257604", "R-RNO-9028731", "R-GGA-388844", "R-HSA-198203", "R-MMU-9026527"], "pathways": ["R-HSA-167044:r:Signalling to RAS", "R-HSA-187042:r:TRKA activation by NGF", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-HSA-198745:r:Signalling to STAT3", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-198203:r:PI3K/AKT activation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-187042:r:TRKA activation by NGF", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-RNO-170968:r:Frs2-mediated activation", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-170984:r:ARMS-mediated activation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-HSA-170968:r:Frs2-mediated activation", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-170984:r:ARMS-mediated activation", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-198203:r:PI3K/AKT activation", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1"], "type": "Domain"}, "IPR031636": {"description": "Protein kinase G, tetratricopeptide repeat containing domain", "go_ids": [], "go_terms": [], "name": "PknG_TPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031638": {"description": "Melanoregulin", "go_ids": ["GO:0032402", "GO:0042470"], "go_terms": ["GO:0032402:melanosome transport:P", "GO:0042470:melanosome:C"], "name": "Melanoregulin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031639": {"description": "Annelid erythrocruorin linker subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "Eryth_link_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031640": {"description": "Glucose dehydrogenase, C-terminal", "go_ids": [], "go_terms": [], "name": "Glu_dehyd_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031641": {"description": "Phthiocerol/phthiodiolone dimycocerosyl transferase, C-terminal", "go_ids": [], "go_terms": [], "name": "PapA_C", "pathway_ids": ["PWY-7744", "PWY-7743", "R-MTU-9635470"], "pathways": ["PWY-7744:t:dimycocerosyl phthiocerol biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis"], "type": "Domain"}, "IPR031643": {"description": "Domain of unknown function DUF4708", "go_ids": [], "go_terms": [], "name": "DUF4708", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031644": {"description": "E3 ubiquitin-protein ligase makorin 1, C-terminal", "go_ids": [], "go_terms": [], "name": "MKRN1_C", "pathway_ids": ["PWY-7511", "R-DRE-8948751", "R-MMU-198323", "R-MMU-983168", "R-HSA-8948751", "R-HSA-983168", "R-MMU-8948751", "R-DRE-198323", "R-HSA-198323", "R-DRE-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR031648": {"description": "Transmembrane protein 82", "go_ids": [], "go_terms": [], "name": "TMEM82", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031649": {"description": "Voltage-dependent L-type calcium channel, IQ-associated domain", "go_ids": [], "go_terms": [], "name": "GPHH_dom", "pathway_ids": ["R-DME-5576893", "R-RNO-5576893", "R-GGA-422356", "R-DME-422356", "R-MMU-422356", "R-RNO-112308", "R-MMU-5576892", "R-HSA-400042", "R-HSA-5576892", "R-HSA-419037", "R-RNO-422356", "R-MMU-5576893", "R-HSA-9662360", "R-HSA-5576893", "R-DME-5576892", "R-HSA-112308", "R-MMU-112308", "R-RNO-5576892", "R-HSA-422356"], "pathways": ["R-DME-5576893:r:Phase 2 - plateau phase", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-GGA-422356:r:Regulation of insulin secretion", "R-DME-422356:r:Regulation of insulin secretion", "R-MMU-422356:r:Regulation of insulin secretion", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-422356:r:Regulation of insulin secretion", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-DME-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR031650": {"description": "Coiled-coil domain-containing protein 73", "go_ids": [], "go_terms": [], "name": "CCDC73", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031651": {"description": "Domain of unknown function DUF4709", "go_ids": [], "go_terms": [], "name": "DUF4709", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031652": {"description": "Phosphoribosylformylglycinamidine subunit PurL, C-terminal", "go_ids": [], "go_terms": [], "name": "PurL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031653": {"description": "MAPK-interacting and spindle-stabilising protein", "go_ids": [], "go_terms": [], "name": "MISS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031654": {"description": "Major capsid protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Capsid_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031655": {"description": "FokI, D3 domain", "go_ids": [], "go_terms": [], "name": "FokI_D3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031656": {"description": "Alpha-glycerophosphate oxidase, C-terminal", "go_ids": [], "go_terms": [], "name": "DAO_C", "pathway_ids": ["PWY-6118", "PWY-4261", "PWY-6952", "R-RNO-163560", "R-MMU-1483166", "R-DDI-163560", "R-CEL-163560", "R-SPO-1483166", "R-RNO-1483166", "R-SCE-163560", "R-DDI-1483166", "R-BTA-1483166", "R-MMU-163560", "R-HSA-1483166", "R-SPO-163560", "R-CEL-1483166", "R-BTA-163560", "R-SCE-1483166", "R-HSA-163560"], "pathways": ["PWY-6118:t:glycerol-3-phosphate shuttle", "PWY-4261:t:glycerol degradation I", "PWY-6952:t:glycerophosphodiester degradation", "R-RNO-163560:r:Triglyceride catabolism", "R-MMU-1483166:r:Synthesis of PA", "R-DDI-163560:r:Triglyceride catabolism", "R-CEL-163560:r:Triglyceride catabolism", "R-SPO-1483166:r:Synthesis of PA", "R-RNO-1483166:r:Synthesis of PA", "R-SCE-163560:r:Triglyceride catabolism", "R-DDI-1483166:r:Synthesis of PA", "R-BTA-1483166:r:Synthesis of PA", "R-MMU-163560:r:Triglyceride catabolism", "R-HSA-1483166:r:Synthesis of PA", "R-SPO-163560:r:Triglyceride catabolism", "R-CEL-1483166:r:Synthesis of PA", "R-BTA-163560:r:Triglyceride catabolism", "R-SCE-1483166:r:Synthesis of PA", "R-HSA-163560:r:Triglyceride catabolism"], "type": "Domain"}, "IPR031657": {"description": "Replication protein A, OB domain", "go_ids": [], "go_terms": [], "name": "REPA_OB_2", "pathway_ids": ["R-HSA-5693616", "R-GGA-174437", "R-HSA-5696397", "R-GGA-110314", "R-MMU-110320", "R-MMU-6804756", "R-GGA-351468", "R-HSA-5655862", "R-MMU-5685938", "R-MMU-110314", "R-MMU-69473", "R-MMU-5696395", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-MMU-174437", "R-GGA-6782135", "R-HSA-5656121", "R-GGA-5696400", "R-MMU-5358606", "R-MMU-5358565", "R-GGA-68962", "R-DRE-6804756", "R-DRE-6782210", "R-GGA-110320", "R-HSA-69473", "R-MMU-5651801", "R-MMU-68962", "R-DRE-5685942", "R-HSA-110312", "R-GGA-6782210", "R-HSA-6783310", "R-DRE-3371453", "R-DRE-174437", "R-GGA-110312", "R-GGA-5656169", "R-HSA-6804756", "R-GGA-5358565", "R-GGA-5651801", "R-DRE-69473", "R-HSA-5696395", "R-DRE-5358565", "R-MMU-176187", "R-MMU-6782210", "R-MMU-3108214", "R-GGA-5693607", "R-MMU-5696397", "R-GGA-176187", "R-HSA-110314", "R-HSA-3371511", "R-DRE-5358606", "R-DRE-5693607", "R-GGA-5685938", "R-DRE-176187", "R-HSA-3108214", "R-HSA-5685942", "R-GGA-3108214", "R-GGA-5685942", "R-MMU-6782135", "R-GGA-5358606", "R-HSA-5358606", "R-DRE-5656121", "R-DRE-5696400", "R-MMU-110312", "R-GGA-5655862", "R-DRE-5656169", "R-DRE-5696395", "R-DRE-69166", "R-DRE-3108214", "R-GGA-353303", "R-HSA-912446", "R-HSA-68962", "R-HSA-6782210", "R-HSA-5656169", "R-DRE-110312", "R-HSA-5685938", "R-HSA-176187", "R-MMU-5696400", "R-MMU-5693607", "R-MMU-3371453", "R-MMU-5655862", "R-GGA-6783310", "R-GGA-351451", "R-DRE-5696397", "R-GGA-5696397", "R-GGA-5656121", "R-DRE-5655862", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-HSA-69166", "R-GGA-3371453", "R-GGA-5696395", "R-MMU-6783310", "R-MMU-5656121", "R-DRE-110320", "R-DRE-6782135", "R-DRE-68962", "R-MMU-69166", "R-HSA-5696400", "R-HSA-5358565", "R-DRE-5651801", "R-DRE-110314", "R-HSA-174437", "R-GGA-69166", "R-HSA-110320", "R-DRE-5685938"], "pathways": ["R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-GGA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-351468:r:Processing of DNA double-strand break ends", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-6782135:r:Dual incision in TC-NER", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-GGA-68962:r:Activation of the pre-replicative complex", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-110312:r:Translesion synthesis by REV1", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-GGA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-3371511:r:HSF1 activation", "R-DRE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DRE-176187:r:Activation of ATR in response to replication stress", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-GGA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DRE-5656121:r:Translesion synthesis by POLI", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-MMU-110312:r:Translesion synthesis by REV1", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-DRE-5656169:r:Termination of translesion DNA synthesis", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-69166:r:Removal of the Flap Intermediate", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-912446:r:Meiotic recombination", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DRE-110312:r:Translesion synthesis by REV1", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-GGA-6783310:r:Fanconi Anemia Pathway", "R-GGA-351451:r:Homologous recombination repair of replication-dependent double-strand breaks", "R-DRE-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-DRE-5655862:r:Translesion synthesis by POLK", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-GGA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-DRE-6782135:r:Dual incision in TC-NER", "R-DRE-68962:r:Activation of the pre-replicative complex", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-69166:r:Removal of the Flap Intermediate", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR031658": {"description": "Cyclin, C-terminal domain 2", "go_ids": [], "go_terms": [], "name": "Cyclin_C_2", "pathway_ids": ["R-RNO-6781823", "R-HSA-1989781", "R-RNO-6782135", "R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-BTA-9841922", "R-SCE-75953", "R-MMU-113418", "R-RNO-674695", "R-RNO-73779", "R-HSA-427413", "R-HSA-69273", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-RNO-73863", "R-HSA-69231", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-HSA-9841922", "R-HSA-6781823", "R-MMU-112382", "R-RNO-73776", "R-SPO-5696395", "R-SPO-76042", "R-HSA-167246", "R-HSA-73776", "R-HSA-69656", "R-MMU-5696395", "R-DDI-674695", "R-HSA-75953", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-HSA-2122947", "R-MMU-76042", "R-HSA-212436", "R-SPO-75953", "R-RNO-6782210", "R-SPO-113418", "R-DDI-73779", "R-RNO-76042", "R-DDI-69656", "R-MMU-2173796", "R-RNO-5696395", "R-DDI-6781823", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-RNO-8939236", "R-SCE-76042", "R-HSA-167161", "R-SPO-69202", "R-MMU-69656", "R-HSA-167200", "R-RNO-112382", "R-SCE-674695", "R-HSA-167160", "R-HSA-5696395", "R-DDI-77075", "R-SPO-73779", "R-RNO-9841922", "R-HSA-2644606", "R-DDI-113418", "R-MMU-73772", "R-DDI-69202", "R-MMU-6782210", "R-SPO-73776", "R-MMU-72086", "R-MMU-69273", "R-RNO-75953", "R-SCE-6782135", "R-SCE-73776", "R-RNO-2173796", "R-DDI-6782135", "R-MMU-69231", "R-MMU-73762", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-HSA-72086", "R-BTA-2173796", "R-HSA-167162", "R-MMU-8939236", "R-MMU-69202", "R-MMU-6781823", "R-SPO-69656", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-RNO-69656", "R-MMU-73776", "R-HSA-9833110", "R-DDI-76042", "R-SCE-6782210", "R-HSA-167172", "R-HSA-2173796", "R-BTA-212436", "R-SCE-6796648", "R-SCE-73779", "R-RNO-113418", "R-RNO-69202", "R-SPO-77075", "R-RNO-72086", "R-MMU-6796648", "R-RNO-73772", "R-RNO-6796648", "R-SPO-69231", "R-SCE-113418", "R-SCE-72086", "R-HSA-2894862", "R-HSA-381340", "R-SCE-6781823", "R-DDI-69231", "R-MMU-73863", "R-HSA-6782135", "R-RNO-75955", "R-HSA-73762", "R-RNO-69273", "R-RNO-69231", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-DME-9841922", "R-SPO-6782210", "R-SCE-77075", "R-DME-2173796", "R-HSA-674695", "R-SPO-6782135", "R-HSA-76042", "R-SCE-73772", "R-DDI-75953", "R-HSA-69202", "R-HSA-8939236", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-212436:r:Generic Transcription Pathway", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167161:r:HIV Transcription Initiation", "R-SPO-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-69231:r:Cyclin D associated events in G1", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-72086:r:mRNA Capping", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9833110:r:RSV-host interactions", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-212436:r:Generic Transcription Pathway", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-72086:r:mRNA Capping", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-69231:r:Cyclin D associated events in G1", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-69231:r:Cyclin D associated events in G1", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR031659": {"description": "Spermatogenesis-associated protein 9", "go_ids": [], "go_terms": [], "name": "SPATA9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031660": {"description": "C-terminal associated domain of TOPRIM", "go_ids": [], "go_terms": [], "name": "TOPRIM_C", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-SPO-4615885", "R-HSA-1362277", "R-DME-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Domain"}, "IPR031661": {"description": "Bcl-2-binding component 3", "go_ids": ["GO:0005739", "GO:0097193", "GO:0043065", "GO:0090200"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0097193:intrinsic apoptotic signaling pathway:P", "GO:0043065:positive regulation of apoptotic process:P", "GO:0090200:positive regulation of release of cytochrome c from mitochondria:P"], "name": "Bbc3", "pathway_ids": ["R-HSA-9614657", "R-HSA-6803204", "R-HSA-139915", "R-HSA-111453"], "pathways": ["R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "type": "Family"}, "IPR031662": {"description": "GTP binding protein, second domain", "go_ids": [], "go_terms": [], "name": "GTP-binding_2", "pathway_ids": ["R-DME-9629569", "R-MMU-9629569", "R-BTA-9629569", "R-DDI-9629569", "R-HSA-9629569"], "pathways": ["R-DME-9629569:r:Protein hydroxylation", "R-MMU-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-DDI-9629569:r:Protein hydroxylation", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Domain"}, "IPR031663": {"description": "Phosphogluconate dehydrogenase (decarboxylating) , C-terminal", "go_ids": [], "go_terms": [], "name": "PGDH_C", "pathway_ids": ["PWY-8091", "PWY-8090", "PWY-8092"], "pathways": ["PWY-8091:t:D-apionate degradation I (xylose isomerase family decarboxylase)", "PWY-8090:t:D-apionate degradation II (RLP decarboxylase)", "PWY-8092:t:D-apionate degradation III (RLP transcarboxylase/hydrolase)"], "type": "Domain"}, "IPR031664": {"description": "Protein of unknown function DUF5085", "go_ids": [], "go_terms": [], "name": "DUF5085", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031666": {"description": "Protein of unknown function DUF5084", "go_ids": [], "go_terms": [], "name": "DUF5084", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031667": {"description": "Required for drug-induced death protein 1", "go_ids": [], "go_terms": [], "name": "RDD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031668": {"description": "Protein of unknown function DUF4711", "go_ids": [], "go_terms": [], "name": "DUF4711", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031669": {"description": "Fibronectin type III domain, fungi", "go_ids": [], "go_terms": [], "name": "Fn3_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031670": {"description": "Protein of unknown function DUF4712", "go_ids": [], "go_terms": [], "name": "DUF4712", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031671": {"description": "Small integral membrane protein 5/18/22", "go_ids": [], "go_terms": [], "name": "SMIM5/18/22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031672": {"description": "FAM27D/FAM27E", "go_ids": [], "go_terms": [], "name": "FAM27D/FAM27E", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031673": {"description": "Chitin biosynthesis protein Chs5, N-terminal", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "Chs5_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031674": {"description": "Protein of unknown function DUF4714", "go_ids": [], "go_terms": [], "name": "DUF4714", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031675": {"description": "Serine-threonine protein phosphatase, N-terminal", "go_ids": [], "go_terms": [], "name": "STPPase_N", "pathway_ids": ["R-SSC-5673000", "R-RNO-5627123", "R-MMU-9770562", "R-MMU-2467813", "R-GGA-2565942", "R-MMU-5625740", "R-CEL-5673000", "R-MMU-68877", "R-MMU-2565942", "R-XTR-141444", "R-HSA-5673000", "R-HSA-9828806", "R-RNO-5625740", "R-HSA-9931530", "R-BTA-2565942", "R-CEL-9770562", "R-BTA-2500257", "R-SSC-2565942", "R-SSC-5625740", "R-XTR-5625740", "R-CEL-2500257", "R-RNO-5673000", "R-BTA-5625740", "R-SPO-2500257", "R-DME-538898", "R-MMU-141444", "R-DME-5627123", "R-MMU-5673000", "R-HSA-141444", "R-DME-2500257", "R-HSA-9648025", "R-SCE-2500257", "R-CFA-180024", "R-RNO-5663220", "R-RNO-180024", "R-DME-350416", "R-SPO-9770562", "R-HSA-9726840", "R-BTA-9770562", "R-MMU-5627123", "R-RNO-2467813", "R-BTA-9648025", "R-BTA-5673000", "R-GGA-5673000", "R-MMU-5663220", "R-RNO-141444", "R-HSA-5625900", "R-HSA-2467813", "R-RNO-2500257", "R-XTR-9770562", "R-XTR-2467813", "R-HSA-5625740", "R-DDI-9770562", "R-BTA-5663220", "R-DME-2565942", "R-DME-5625740", "R-BTA-5627123", "R-GGA-5627123", "R-HSA-2565942", "R-DME-9770562", "R-XTR-5627123", "R-BTA-2467813", "R-RNO-2565942", "R-CFA-9770562", "R-HSA-68877", "R-MMU-180024", "R-SSC-5627123", "R-GGA-9770562", "R-MMU-9648025", "R-HSA-180024", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-HSA-2500257", "R-HSA-9770562", "R-XTR-5663220", "R-DME-350480", "R-DDI-2500257", "R-XTR-68877", "R-HSA-9726842", "R-HSA-163560", "R-XTR-180024", "R-BTA-180024", "R-HSA-5627123", "R-XTR-2565942", "R-RNO-9770562", "R-HSA-5663220", "R-RNO-9648025", "R-SSC-9770562", "R-HSA-2173788", "R-BTA-141444", "R-XTR-2500257", "R-HSA-5627117"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M 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"R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-538898:r:Dephosphorylation of TIM", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-MMU-5673000:r:RAF activation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CFA-180024:r:DARPP-32 events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-180024:r:DARPP-32 events", "R-DME-350416:r:Regulation of non-muscle Myosin II", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-5673000:r:RAF activation", "R-GGA-5673000:r:RAF activation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9770562:r:mRNA Polyadenylation", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-DDI-9770562:r:mRNA Polyadenylation", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-9770562:r:mRNA Polyadenylation", "R-XTR-5627123:r:RHO GTPases activate PAKs", 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"R-XTR-180024:r:DARPP-32 events", "R-BTA-180024:r:DARPP-32 events", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-9770562:r:mRNA Polyadenylation", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Domain"}, "IPR031676": {"description": "Protein of unknown function DUF5083", "go_ids": [], "go_terms": [], "name": "DUF5083", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031677": {"description": "Testis-expressed sequence 38 protein", "go_ids": [], "go_terms": [], "name": "TEX38", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031678": {"description": "Protein of unknown function DUF4715", "go_ids": [], "go_terms": [], "name": "DUF4715", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031679": {"description": "TSSK6-activating co-chaperone protein", "go_ids": ["GO:0051087"], "go_terms": ["GO:0051087:protein-folding chaperone binding:F"], "name": "SSTK-IP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031680": {"description": "Heparin-sulfate lyase, N-terminal", "go_ids": [], "go_terms": [], "name": "Hepar_II_III_N", "pathway_ids": ["PWY-7651"], "pathways": ["PWY-7651:t:heparan sulfate degradation"], "type": "Domain"}, "IPR031681": {"description": "YwqH-like", "go_ids": [], "go_terms": [], "name": "YwqH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031682": {"description": "Type VII secretion system protein EsaE", "go_ids": [], "go_terms": [], "name": "EsaE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031684": {"description": "Sperm-egg fusion 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"R-HSA-983712", "R-PFA-1222556", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-HSA-917977", "R-MMU-983712", "R-DDI-983712", "R-DDI-917977", "R-BTA-77387", "R-PFA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["PWY-7980:t:ATP biosynthesis", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-PFA-917977:r:Transferrin endocytosis and recycling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-MMU-77387:r:Insulin receptor recycling", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-SCE-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-PFA-1222556:r:ROS and RNS production in phagocytes", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-BTA-77387:r:Insulin receptor recycling", "R-PFA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR031687": {"description": "ADP-ribosylation factor-like protein 17, C-terminal", "go_ids": [], "go_terms": [], "name": "ARL17_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031688": {"description": "Voltage-gated calcium channel subunit alpha, C-terminal", "go_ids": [], "go_terms": [], "name": "CAC1F_C", "pathway_ids": ["R-DME-5576893", "R-RNO-422356", "R-GGA-422356", "R-RNO-5576893", "R-HSA-9662360", "R-MMU-5576893", "R-HSA-5576893", "R-MMU-422356", "R-DME-422356", "R-MMU-5576892", "R-HSA-422356", "R-HSA-400042", "R-DME-5576892", "R-HSA-5576892", "R-HSA-419037", "R-RNO-5576892"], "pathways": ["R-DME-5576893:r:Phase 2 - plateau phase", "R-RNO-422356:r:Regulation of insulin secretion", "R-GGA-422356:r:Regulation of insulin secretion", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-MMU-422356:r:Regulation of insulin secretion", "R-DME-422356:r:Regulation of insulin secretion", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-DME-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-5576892:r:Phase 0 - rapid depolarisation"], "type": "Domain"}, "IPR031689": {"description": "Protein of unknown function DUF5080", "go_ids": [], 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"R-HSA-400206", "R-HSA-9022699", "R-HSA-3899300", "R-MMU-9825892", "R-HSA-9825892", "R-HSA-9701898", "R-MMU-400206", "R-MMU-9707564"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9022538:r:Loss of MECP2 binding ability to 5mC-DNA", "R-CEL-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR031694": {"description": "Transmembrane protein 239", "go_ids": [], "go_terms": [], "name": "TMEM239", "pathway_ids": [], 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"R-HSA-4419969", "R-HSA-1483213", "R-MMU-75109", "R-HSA-75109", "R-MMU-1483191", "R-MMU-4419969", "R-MMU-1483213", "R-HSA-9841922"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-8053:t:anandamide biosynthesis II", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "R-HSA-1483191:r:Synthesis of PC", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-1483213:r:Synthesis of PE", "R-MMU-75109:r:Triglyceride biosynthesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-MMU-1483191:r:Synthesis of PC", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-1483213:r:Synthesis of PE", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "type": "Domain"}, "IPR031704": {"description": "Glycosyl hydrolase family 36, N-terminal", "go_ids": [], 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glycosylation ligase domain", "go_ids": [], "go_terms": [], "name": "PglL_A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031728": {"description": "Beta-glucuronidase, C-terminal", "go_ids": [], "go_terms": [], "name": "GlcAase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031729": {"description": "Fanconi anaemia group A protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Fanconi_A_N", "pathway_ids": ["R-HSA-6783310", "R-HSA-9833482", "R-MMU-9833482", "R-MMU-6783310"], "pathways": ["R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR031730": {"description": "Carbamoyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "Carbam_trans_C", "pathway_ids": ["PWY-8344", "PWY-7694", "PWY-7693", "PWY-8039", "PWY-5"], "pathways": ["PWY-8344:t:ansamitocin P biosynthesis", "PWY-7694:t:zwittermicin A 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the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR031746": {"description": "Protein of unknown function DUF4732", "go_ids": [], "go_terms": [], "name": "DUF4732", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031747": {"description": "Transmembrane protein 232", "go_ids": [], "go_terms": [], "name": "TMEM232", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031748": {"description": "Protein Frey", "go_ids": [], "go_terms": [], "name": "Frey", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031749": {"description": "Cell division control protein 13, N-terminal", "go_ids": [], "go_terms": [], "name": "Cdc13_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031750": {"description": "Domain of unknown function DUF4734", "go_ids": [], "go_terms": [], "name": "DUF4734", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031751": {"description": "Protein of unknown function DUF4735", "go_ids": [], "go_terms": [], "name": "DUF4735", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031752": {"description": "Herpes viral adaptor, REF-binding domain", "go_ids": [], "go_terms": [], "name": "HHV-1_REF-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031753": {"description": "Stomagen", "go_ids": ["GO:2000123"], "go_terms": ["GO:2000123:positive regulation of stomatal complex development:P"], "name": "Stomagen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031754": {"description": "Protein of unknown function DUF4736", "go_ids": [], "go_terms": [], "name": "DUF4736", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031755": {"description": "Peptidase inhibitor I66", "go_ids": ["GO:0004867"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F"], "name": "Inhibitor_I66", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031756": {"description": "Beta-1,3-glucan-binding protein, N-terminal", 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[], "name": "FOG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031762": {"description": "Protein of unknown function DUF4738", "go_ids": [], "go_terms": [], "name": "DUF4738", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031763": {"description": "Dinitrogenase iron-molybdenum cofactor, N-terminal", "go_ids": [], "go_terms": [], "name": "NafY_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031764": {"description": "Domain of unknown function DUF4739", "go_ids": [], "go_terms": [], "name": "DUF4739", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031765": {"description": "Mdy2, Get4 binding domain", "go_ids": [], "go_terms": [], "name": "Mdy2_get4-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031766": {"description": "Occluded RNA-recognition motif", "go_ids": [], "go_terms": [], "name": "RRM_occluded", "pathway_ids": ["R-SPO-72163", "R-SPO-9770562", "R-SPO-72203"], "pathways": ["R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Domain"}, "IPR031767": {"description": "Inhibitor of glucose uptake transporter SgrT", "go_ids": ["GO:0046325"], "go_terms": ["GO:0046325:negative regulation of D-glucose import across plasma membrane:P"], "name": "SgrT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031768": {"description": "Carbohydrate binding module, xylan-binding domain", "go_ids": [], "go_terms": [], "name": "CBM60_xylan-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031769": {"description": "Actin-like protein 7A, N-terminal", "go_ids": [], "go_terms": [], "name": "ACTL7A_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031770": {"description": "Antibacterial factor-related peptide", "go_ids": ["GO:0098542"], "go_terms": ["GO:0098542:defense response to other organism:P"], "name": "Abf-1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031771": {"description": "CAAX box protein 1", "go_ids": [], "go_terms": [], "name": "CAAX_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031772": {"description": "Tail knob protein gp9, N-terminal", "go_ids": [], "go_terms": [], "name": "Gp9_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031773": {"description": "Protein of unknown function DUF4741", "go_ids": [], "go_terms": [], "name": "DUF4741", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031774": {"description": "SF3A3 domain", "go_ids": [], "go_terms": [], "name": "SF3A3_dom", "pathway_ids": ["R-DME-9770562", "R-DME-72163", "R-SPO-9770562", "R-HSA-72163", "R-HSA-9770562", "R-HSA-9918481", "R-MMU-9770562", "R-MMU-72163"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR031775": {"description": "cGMP-dependent protein kinase, interacting domain", "go_ids": ["GO:0019901"], "go_terms": ["GO:0019901:protein kinase binding:F"], "name": "PRKG1_interact", "pathway_ids": ["R-GGA-5627123", "R-RNO-5627123", "R-HSA-5625900", "R-HSA-5627123", "R-RNO-5625740", "R-RNO-2565942", "R-DRE-2565942", "R-DRE-5625740", "R-MMU-5627123", "R-HSA-5625740", "R-MMU-5625740", "R-GGA-2565942", "R-MMU-2565942", "R-HSA-5627117", "R-HSA-2565942"], "pathways": ["R-GGA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR031777": {"description": "Sortilin, C-terminal", "go_ids": [], "go_terms": [], "name": "Sortilin_C", "pathway_ids": ["R-HSA-432722", "R-RNO-432722", "R-HSA-977225", "R-MMU-432722"], "pathways": ["R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR031778": {"description": "Sortilin, N-terminal", "go_ids": [], "go_terms": [], "name": "Sortilin_N", "pathway_ids": ["R-HSA-432722", "R-RNO-432722", "R-HSA-977225", "R-MMU-432722"], "pathways": ["R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR031779": {"description": "Shu complex, component Psy3", "go_ids": ["GO:0097196", "GO:0000725", "GO:0005634"], "go_terms": ["GO:0097196:Shu complex:C", "GO:0000725:recombinational repair:P", "GO:0005634:nucleus:C"], "name": "Psy3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031780": {"description": "RIPOR1-3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RIPOR1-3_N", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR031781": {"description": "SF3A2 domain", "go_ids": [], "go_terms": [], "name": "SF3A2_dom", "pathway_ids": ["R-HSA-72163", "R-SPO-9770562", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-RNO-9770562", "R-BTA-9770562", "R-RNO-72163", "R-DDI-9770562", "R-HSA-9918481", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR031782": {"description": "LKB1 serine/threonine kinase interacting protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "LIP1_N", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR031783": {"description": "Chromosome segregation in meiosis protein 2", "go_ids": ["GO:0000725", "GO:0097196", "GO:0005634"], "go_terms": ["GO:0000725:recombinational repair:P", "GO:0097196:Shu complex:C", "GO:0005634:nucleus:C"], "name": "Csm2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031784": {"description": "Krueppel-like factor 1, transactivation domain 2", "go_ids": [], "go_terms": [], "name": "EKLF_TAD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031786": {"description": "Krueppel-like factor 1, transactivation domain 1", "go_ids": [], "go_terms": [], "name": "EKLF_TAD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031788": {"description": "CS6 fimbrial subunit A/B", "go_ids": [], "go_terms": [], "name": "CssA/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031789": {"description": "RBP2b domain", "go_ids": [], "go_terms": [], "name": "RBP2b_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031790": {"description": "Nitric oxide synthase-interacting protein, zinc-finger", "go_ids": [], "go_terms": [], "name": "Znf-NOSIP", "pathway_ids": ["PWY-7511", "R-BTA-203754", "R-HSA-203754", "R-MMU-203754", "R-DDI-203754", "R-DME-203754"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-DDI-203754:r:NOSIP mediated eNOS trafficking", "R-DME-203754:r:NOSIP mediated eNOS trafficking"], "type": "Domain"}, "IPR031791": {"description": "Avirulence protein ATR13", "go_ids": [], "go_terms": [], "name": "ATR13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031792": {"description": "Surface antigen, GAG-binding domain", "go_ids": [], "go_terms": [], "name": "GAG_BD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031793": {"description": "Integrin-alpha FG-GAP repeat-containing protein 2", "go_ids": [], "go_terms": [], "name": "KICSTOR_ITFG2", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR031794": {"description": "Hyaluronan-mediated motility receptor, C-terminal", "go_ids": [], "go_terms": [], "name": "HMMR_C", "pathway_ids": ["R-RNO-2132295", "R-HSA-2132295", "R-RNO-6811434", "R-HSA-2142845", "R-HSA-2160916", "R-MMU-2142845", "R-HSA-983189", "R-RNO-983189", "R-MMU-2132295", "R-HSA-6811434", "R-MMU-8854518", "R-MMU-983189", "R-MMU-2160916", "R-HSA-8854518", "R-MMU-6811434"], "pathways": ["R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-2142845:r:Hyaluronan metabolism", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-HSA-983189:r:Kinesins", "R-RNO-983189:r:Kinesins", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-983189:r:Kinesins", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR031795": {"description": "Putative zinc-finger containing protein", "go_ids": [], "go_terms": [], "name": "Zf-HC3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031796": {"description": "Protein of unknown function DUF5076", "go_ids": [], "go_terms": [], "name": "DUF5076", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031797": {"description": "IGP family C-type lectin domain", "go_ids": [], "go_terms": [], "name": "DUF5075", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031798": {"description": "Alginate biosynthesis protein AlgX, C-terminal carbohydrate-binding module", "go_ids": [], "go_terms": [], "name": "AlgX_C", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR031799": {"description": "C2H2-type zinc ribbon", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_ribbon", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031800": {"description": "Cyclic di-GMP receptor, atypical PilZ domain", "go_ids": [], "go_terms": [], "name": "PilZ_atypical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031801": {"description": "Virilizer, N-terminal", "go_ids": [], "go_terms": [], "name": "VIR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031802": {"description": "FAM193, C-terminal", "go_ids": [], "go_terms": [], "name": "FAM193_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031803": {"description": "Bacterioopsin transcriptional activator, GAF and HTH associated domain", "go_ids": [], "go_terms": [], "name": "BAT_GAF/HTH-assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031804": {"description": "Domain of unknown function DUF4743", "go_ids": [], "go_terms": [], "name": "DUF4743", "pathway_ids": ["R-SPO-196819"], "pathways": ["R-SPO-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Domain"}, "IPR031805": {"description": "Piezo, TM25-28", "go_ids": [], "go_terms": [], "name": "Piezo_TM25-28", "pathway_ids": ["R-HSA-9860927", "R-HSA-9856532", "R-HSA-9856530"], "pathways": ["R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Domain"}, "IPR031806": {"description": "Domain of unknown function DUF4744", "go_ids": [], "go_terms": [], "name": "DUF4744", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031807": {"description": "HicB-like antitoxin of toxin-antitoxin system", "go_ids": [], "go_terms": [], "name": "HicB-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031808": {"description": "JMY/WHAMM, N-terminal", "go_ids": [], "go_terms": [], "name": "JMY/WHAMM_N", "pathway_ids": ["R-HSA-6804760", "R-HSA-9013405", "R-MMU-6804760"], "pathways": ["R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation"], "type": "Domain"}, "IPR031809": {"description": "Coiled-coil domain-containing protein 158", "go_ids": [], "go_terms": [], "name": "CCDC158", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031810": {"description": "YjeJ-like", "go_ids": [], "go_terms": [], "name": "YjeJ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031811": {"description": "AlgX/AlgJ, SGNH hydrolase-like domain", "go_ids": [], "go_terms": [], "name": "ALGX/ALGJ_SGNH-like", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR031812": {"description": "Protein C", "go_ids": [], "go_terms": [], "name": "C_Hendra", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031813": {"description": "Domain of unknown function DUF4745", "go_ids": [], "go_terms": [], "name": "DUF4745", "pathway_ids": ["R-HSA-9013423", "R-HSA-9013149", "R-HSA-9013408", "R-HSA-9013404"], "pathways": ["R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle"], "type": "Domain"}, "IPR031814": {"description": "ALG11 mannosyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "ALG11_N", "pathway_ids": ["R-HSA-4551295", "R-HSA-446193"], "pathways": ["R-HSA-4551295:r:Defective ALG11 causes CDG-1p", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Domain"}, "IPR031815": {"description": "Protein of unknown function DUF5074", "go_ids": [], "go_terms": [], "name": "DUF5074", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031816": {"description": "Protein of unknown function DUF5073", "go_ids": [], "go_terms": [], "name": "DUF5073", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031817": {"description": "DotD protein", "go_ids": [], "go_terms": [], "name": "DotD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031818": {"description": "Protein Hri1", "go_ids": [], "go_terms": [], "name": "Hri1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031819": {"description": "Read-through domain", "go_ids": [], "go_terms": [], "name": "Read-through_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031820": {"description": "CRISPR-associated protein Csn2 subfamily St", "go_ids": [], "go_terms": [], "name": "Cas_St_Csn2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031821": {"description": "SOSS complex subunit C", "go_ids": ["GO:0006974", "GO:0070876", "GO:0005634", "GO:0006281"], "go_terms": ["GO:0006974:DNA damage response:P", "GO:0070876:SOSS complex:C", "GO:0005634:nucleus:C", "GO:0006281:DNA repair:P"], "name": "SOSSC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031822": {"description": "Fiber protein 1, C-terminal", "go_ids": [], "go_terms": [], "name": "AdHead_fibreRBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031823": {"description": "TRAP transporter T-component", "go_ids": [], "go_terms": [], "name": "TatT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031824": {"description": "E3 ubiquitin-protein ligase RNF220, middle domain", "go_ids": [], "go_terms": [], "name": "RNF220_mid", "pathway_ids": ["PWY-7511", "R-HSA-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR031825": {"description": "RXLR phytopathogen effector protein", "go_ids": [], "go_terms": [], "name": "RXLR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031826": {"description": "IC97/Casc1, N-terminal", "go_ids": [], "go_terms": [], "name": "IC97/Casc1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031827": {"description": "Domain of unknown function DUF4746", "go_ids": [], "go_terms": [], "name": "DUF4746", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031828": {"description": "Myofilin", "go_ids": [], "go_terms": [], "name": "Myofilin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031829": {"description": "Effector protein NleF", "go_ids": [], "go_terms": [], "name": "NleF", "pathway_ids": ["R-HSA-9956593"], "pathways": ["R-HSA-9956593:r:Enterobacterial factors antagonize host defense"], "type": "Family"}, "IPR031830": {"description": "Uncharacterised protein YdiH", "go_ids": [], "go_terms": [], "name": "YdiH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031831": {"description": "cGMP-dependent protein kinase, N-terminal coiled-coil domain", "go_ids": [], "go_terms": [], "name": "PKcGMP_CC", "pathway_ids": ["R-HSA-418457", "R-MMU-392517", "R-HSA-9918432", "R-BTA-392517", "R-HSA-4086398", "R-MMU-418457", "R-HSA-392517", "R-BTA-418457"], "pathways": ["R-HSA-418457:r:cGMP effects", "R-MMU-392517:r:Rap1 signalling", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-392517:r:Rap1 signalling", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-418457:r:cGMP effects", "R-HSA-392517:r:Rap1 signalling", "R-BTA-418457:r:cGMP effects"], "type": "Domain"}, "IPR031832": {"description": "Protein of unknown function DUF4747", "go_ids": [], "go_terms": [], "name": "DUF4747", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031833": {"description": "Protein of unknown function DUF4748", "go_ids": [], "go_terms": [], "name": "DUF4748", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031834": {"description": "Antitoxin RnlB/LsoB", "go_ids": [], "go_terms": [], "name": "RnlB/LsoB_antitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031835": {"description": "Antiactivator protein ExsD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ExsD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031836": {"description": "Late transcription coactivator", "go_ids": [], "go_terms": [], "name": "Trans_coact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031837": {"description": "Domain of unknown function DUF5071", "go_ids": [], "go_terms": [], "name": "DUF5071", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031838": {"description": "Fe-S cluster assembly protein Dre2, N-terminal", "go_ids": [], "go_terms": [], "name": "Dre2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031839": {"description": "Protein of unknown function DUF5070", "go_ids": [], "go_terms": [], "name": "DUF5070", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031840": {"description": "Protein male-specific lethal-1, dimerisation domain", "go_ids": [], "go_terms": [], "name": "MSL1_dimer", "pathway_ids": ["R-MMU-3214847", "R-HSA-3214847", "R-DRE-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-DRE-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR031841": {"description": "DL-endopeptidase inhibitor IseA", "go_ids": [], "go_terms": [], "name": "Endopep_inhib", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031843": {"description": "Yuri gagarin", "go_ids": [], "go_terms": [], "name": "Yuri_gagarin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031844": {"description": "Voltage-gated hydrogen channel 1, C-terminal membrane-localisation domain", "go_ids": [], "go_terms": [], "name": "VGPC1_C", "pathway_ids": ["R-MMU-1300642", "R-MMU-6798695", "R-MMU-1222556", "R-HSA-6798695", "R-HSA-1222556", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR031845": {"description": "Bacterial toxin, RNase RnlA/LsoA, N-terminal repeated domain", "go_ids": [], "go_terms": [], "name": "RnlA_toxin_NRD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031846": {"description": "Voltage-gated hydrogen channel 1", "go_ids": ["GO:0030171", "GO:1902600", "GO:0005886"], "go_terms": ["GO:0030171:voltage-gated proton channel activity:F", "GO:1902600:proton transmembrane transport:P", "GO:0005886:plasma membrane:C"], "name": "Hvcn1", "pathway_ids": ["R-MMU-1300642", "R-HSA-6798695", "R-MMU-1222556", "R-XTR-1222556", "R-XTR-1300642", "R-HSA-1222556", "R-DRE-6798695", "R-HSA-1300642", "R-DRE-1222556", "R-MMU-6798695", "R-DRE-1300642", "R-XTR-6798695"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-XTR-1222556:r:ROS and RNS production in phagocytes", "R-XTR-1300642:r:Sperm Motility And Taxes", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-1300642:r:Sperm Motility And Taxes", "R-DRE-1222556:r:ROS and RNS production in phagocytes", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-1300642:r:Sperm Motility And Taxes", "R-XTR-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR031847": {"description": "PDZ and LIM domain protein 1-4/Zasp-like, middle domain", "go_ids": [], "go_terms": [], "name": "PDLI1-4/Zasp-like_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031848": {"description": "PrlF antitoxin", "go_ids": ["GO:0001558", "GO:0003700", "GO:0097351"], "go_terms": ["GO:0001558:regulation of cell growth:P", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0097351:toxin sequestering activity:F"], "name": "PrlF_antitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031849": {"description": "Domain of unknown function DUF5069", "go_ids": [], "go_terms": [], "name": "DUF5069", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031850": {"description": "Fungal kinase associated-1 domain", "go_ids": [], "go_terms": [], "name": "Fungal_KA1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031851": {"description": "Protein of unknown function DUF4750", "go_ids": [], "go_terms": [], "name": "DUF4750", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031852": {"description": "Spindle pole body-associated protein Vik1/Cik1, microtubule binding domain", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "Vik1/Cik1_MT-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031853": {"description": "Putative antitoxin YmcE", "go_ids": [], "go_terms": [], "name": "YmcE_antitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031854": {"description": "Putative membrane protein FidL-like", "go_ids": [], "go_terms": [], "name": "FidL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031855": {"description": "Protein of unknown function DUF4751", "go_ids": [], "go_terms": [], "name": "DUF4751", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031856": {"description": "Bacterial antitoxin YdaS-like", "go_ids": [], "go_terms": [], "name": "YdaS_toxin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031857": {"description": "Integrase SSV1, C-terminal", "go_ids": [], "go_terms": [], "name": "Integrase_SSV1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031858": {"description": "Protein of unknown function DUF4752", "go_ids": [], "go_terms": [], "name": "DUF4752", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031860": {"description": "Protein of unknown function DUF4754", "go_ids": [], "go_terms": [], "name": "DUF4754", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031861": {"description": "Phage tail base-plate attachment protein, N-terminal barrel domain", "go_ids": [], "go_terms": [], "name": "Caud_bapl16_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031862": {"description": "Gap junction alpha-5 protein (Cx40), C-terminal", "go_ids": [], "go_terms": [], "name": "Cx40_C", "pathway_ids": ["R-HSA-190861", "R-CFA-190861", "R-MMU-190861", "R-RNO-190861"], "pathways": ["R-HSA-190861:r:Gap junction assembly", "R-CFA-190861:r:Gap junction assembly", "R-MMU-190861:r:Gap junction assembly", "R-RNO-190861:r:Gap junction assembly"], "type": "Domain"}, "IPR031863": {"description": "Domain of unknown function DUF4755, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF4755_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031864": {"description": "Protein of unknown function DUF4756", "go_ids": [], "go_terms": [], "name": "DUF4756", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031865": {"description": "Domain of unknown function DUF4757", "go_ids": [], "go_terms": [], "name": "DUF4757", "pathway_ids": ["R-HSA-9725370", "R-HSA-8951664", "R-HSA-983168"], "pathways": ["R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR031866": {"description": "Domain of unknown function DUF4758", "go_ids": [], "go_terms": [], "name": "DUF4758", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031867": {"description": "MiT/TFE transcription factors, N-terminal", "go_ids": [], "go_terms": [], "name": "MiT/TFE_N", "pathway_ids": ["R-MMU-9856649", "R-HSA-9825895", "R-MMU-9824594", "R-HSA-9931510", "R-HSA-9854907", "R-RNO-3232118", "R-HSA-9854909", "R-RNO-9856649", "R-HSA-9926550", "R-HSA-3232118", "R-MMU-3232118", "R-HSA-9857377", "R-HSA-9856649", "R-RNO-9824594", "R-HSA-9824594", "R-HSA-9825892", "R-HSA-9824585"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-MMU-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9854907:r:Regulation of MITF-M dependent genes involved in metabolism", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation"], "type": "Domain"}, "IPR031868": {"description": "Sliding-clamp-loader small subunit gp62", "go_ids": ["GO:0006260", "GO:0003677"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0003677:DNA binding:F"], "name": "Phage_clamp_gp62", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031869": {"description": "YscO-like protein", "go_ids": [], "go_terms": [], "name": "YscO-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031870": {"description": "ATF7-interacting protein , protein binding domain", "go_ids": [], "go_terms": [], "name": "ATF7IP_BD", "pathway_ids": ["R-MMU-9843940", "R-MMU-3214841", "R-DRE-9843940", "R-DRE-3214841", "R-HSA-3214841", "R-GGA-3214841", "R-HSA-9843970", "R-DRE-9843970", "R-HSA-9843940", "R-GGA-9843970", "R-GGA-9843940"], "pathways": ["R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-GGA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-GGA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-GGA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins"], "type": "Domain"}, "IPR031872": {"description": "Ndc10, domain 2", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "NDC10_II", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031874": {"description": "Adult cuticle protein 1", "go_ids": [], "go_terms": [], "name": "Cuticle_Acp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031875": {"description": "Recombination enhancement, RecA-dependent nuclease", "go_ids": [], "go_terms": [], "name": "RecA_dep_nuc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031876": {"description": "Protein of unknown function DUF4760", "go_ids": [], "go_terms": [], "name": "DUF4760", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031877": {"description": "Metal-binding protein SmbP", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "SmbP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031878": {"description": "Commissureless", "go_ids": ["GO:0007411"], "go_terms": ["GO:0007411:axon guidance:P"], "name": "Commissureless", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031879": {"description": "Fanconi anemia group M protein, MHF binding domain", "go_ids": [], "go_terms": [], "name": "FANCM-MHF-bd", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR031881": {"description": "Protein of unknown function DUF4761", "go_ids": [], "go_terms": [], "name": "DUF4761", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031882": {"description": "Protein of unknown function DUF4762", "go_ids": [], "go_terms": [], "name": "DUF4762", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031883": {"description": "Protein of unknown function DUF4763", "go_ids": [], "go_terms": [], "name": "DUF4763", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031884": {"description": "Nucleotide exchange factor Sil1, fungi", "go_ids": ["GO:0005783", "GO:0000774"], "go_terms": ["GO:0005783:endoplasmic reticulum:C", "GO:0000774:adenyl-nucleotide exchange factor activity:F"], "name": "Sil1_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031885": {"description": "Domain of unknown function DUF4764", "go_ids": [], "go_terms": [], "name": "DUF4764", "pathway_ids": ["R-HSA-212436"], "pathways": ["R-HSA-212436:r:Generic Transcription Pathway"], "type": "Domain"}, "IPR031886": {"description": "Domain of unknown function DUF4765", "go_ids": [], "go_terms": [], "name": "DUF4765", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031887": {"description": "Serologically defined colon cancer antigen 8", "go_ids": ["GO:0005813", "GO:0007098"], "go_terms": ["GO:0005813:centrosome:C", "GO:0007098:centrosome cycle:P"], "name": "SDCCAG8", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-2565942", "R-MMU-8854518", "R-MMU-380270", "R-DRE-380320", "R-HSA-380284", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-MMU-380284", "R-HSA-8854518", "R-HSA-380270", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR031888": {"description": "Protein of unknown function DUF5068", "go_ids": [], "go_terms": [], "name": "DUF5068", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031889": {"description": "AIMP2, lysyl-tRNA synthetase binding domain", "go_ids": [], "go_terms": [], "name": "AIMP2_LysRS-bd", "pathway_ids": ["R-MMU-9856649", "R-HSA-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-HSA-379716", "R-RNO-9856649"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Domain"}, "IPR031890": {"description": "F-box only protein 30/40", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "Fbxo30/Fbxo40", "pathway_ids": ["R-MMU-8951664", "R-HSA-983168", "R-RNO-983168", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR031891": {"description": "DNA-mimic protein DMP12", "go_ids": [], "go_terms": [], "name": "DMP12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031892": {"description": "Abi component, membrane-anchored ion channel RexB", "go_ids": [], "go_terms": [], "name": "RexB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031893": {"description": "Phage tail assembly chaperone-like domain", "go_ids": [], "go_terms": [], "name": "Phage_tail_APC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031894": {"description": "Abi component, intracellular sensor of Lambda phage RexA", "go_ids": [], "go_terms": [], "name": "RexA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031895": {"description": "RHH transcriptional regulator CopG", "go_ids": [], "go_terms": [], "name": "RHH_CopG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031896": {"description": "INPP5B, PH domain", "go_ids": [], "go_terms": [], "name": "INPP5B_PH_dom", "pathway_ids": ["R-HSA-1855183", "R-MMU-1855183", "R-HSA-1855204", "R-MMU-1855204"], "pathways": ["R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol"], "type": "Domain"}, "IPR031897": {"description": "DolP-mannose mannosyltransferase AglS", "go_ids": ["GO:0035269", "GO:0004169"], "go_terms": ["GO:0035269:protein O-linked glycosylation via mannose:P", "GO:0004169:dolichyl-phosphate-mannose-protein mannosyltransferase activity:F"], "name": "AglS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031898": {"description": "Zoocin A endopeptidase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ZooA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031899": {"description": "Distal tail protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Dit_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031900": {"description": "Lactococcus phage single-stranded DNA binding protein", "go_ids": [], "go_terms": [], "name": "Phage_SSB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031901": {"description": "Unpaired protein", "go_ids": ["GO:0007259", "GO:0001700"], "go_terms": ["GO:0007259:cell surface receptor signaling pathway via JAK-STAT:P", "GO:0001700:embryonic development via the syncytial blastoderm:P"], "name": "Unpaired", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031902": {"description": "Telomeric repeat-binding factor 2, Rap1-binding domain", "go_ids": [], "go_terms": [], "name": "TERF2_RBM", "pathway_ids": ["R-MMU-174430", "R-MMU-110330", "R-HSA-171306", "R-HSA-174414", "R-MMU-2559586", "R-MMU-174417", "R-HSA-174430", "R-HSA-110328", "R-HSA-1221632", "R-HSA-174411", "R-MMU-110331", "R-MMU-9670095", "R-MMU-171319", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-MMU-174437", "R-HSA-110329", "R-GGA-418124", "R-HSA-110330", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-GGA-418124:r:Telomere maintenance", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Domain"}, "IPR031903": {"description": "Domain of unknown function DUF4766", "go_ids": [], "go_terms": [], "name": "DUF4766", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031904": {"description": "Cadherin, C-terminal catenin-binding domain", "go_ids": [], "go_terms": [], "name": "Cadherin_CBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031905": {"description": "Flotillin, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Flotillin_C", "pathway_ids": ["R-RNO-9013026", "R-SSC-8849932", "R-DME-8980692", "R-BTA-9696273", "R-MMU-9013106", "R-MMU-8849932", "R-MMU-8980692", "R-SSC-5675482", "R-BTA-5213460", "R-MMU-5675482", "R-RNO-8980692", "R-SSC-9013026", "R-BTA-8849932", "R-SSC-8980692", "R-RNO-9696273", "R-DME-8849932", "R-MMU-5213460", "R-BTA-5675482", "R-MMU-9013026", "R-BTA-9696264", "R-RNO-9696264", "R-BTA-8980692", "R-RNO-5675482", "R-SSC-5213460", "R-MMU-9696264", "R-SSC-9013106", "R-MMU-9696273", "R-RNO-5213460", "R-RNO-9013106", "R-RNO-8849932", "R-BTA-9013106"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-SSC-8849932:r:Synaptic adhesion-like molecules", "R-DME-8980692:r:RHOA GTPase cycle", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-BTA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SSC-9013026:r:RHOB GTPase cycle", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-SSC-8980692:r:RHOA GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-MMU-9013026:r:RHOB GTPase cycle", "R-BTA-9696264:r:RND3 GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-SSC-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-9696264:r:RND3 GTPase cycle", "R-SSC-9013106:r:RHOC GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-BTA-9013106:r:RHOC GTPase cycle"], "type": "Domain"}, "IPR031906": {"description": "Regulator of Ty1 transposition protein 107, BRCT domain", "go_ids": [], "go_terms": [], "name": "RTT107_BRCT_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031907": {"description": "Germinal-centre associated nuclear protein, MCM3AP N-terminal domain", "go_ids": [], "go_terms": [], "name": "MCM3AP_GANP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031908": {"description": "Germinal-centre associated nuclear protein, nucleoporin homology domain", "go_ids": [], "go_terms": [], "name": "NupH_GANP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031909": {"description": "Alginate biosynthesis sensor protein KinB, sensor domain", "go_ids": [], "go_terms": [], "name": "KinB_sensor_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031910": {"description": "Germinal-centre associated nuclear protein, CID domain", "go_ids": [], "go_terms": [], "name": "GANP_CID_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031911": {"description": "Pesticin immunity protein", "go_ids": [], "go_terms": [], "name": "Pim", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031912": {"description": "Sharpin, PH domain", "go_ids": [], "go_terms": [], "name": "Sharpin_PH", "pathway_ids": ["R-MMU-5357786", "R-BTA-5357905", "R-HSA-5357905", "R-HSA-5357956", "R-BTA-5357956", "R-MMU-5357905", "R-BTA-5357786", "R-RNO-5357956", "R-RNO-5357905", "R-RNO-5357786", "R-MMU-5357956", "R-HSA-5357786", "R-HSA-6794361"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-6794361:r:Neurexins and neuroligins"], "type": "Domain"}, "IPR031913": {"description": "Spidroin, N-terminal", "go_ids": [], "go_terms": [], "name": "Spidroin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031914": {"description": "XACb0070, ribbon-helix-helix domain", "go_ids": [], "go_terms": [], "name": "XACb0070_RHH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031915": {"description": "Cryptic loci regulator 2, N-terminal", "go_ids": [], "go_terms": [], "name": "Clr2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031916": {"description": "DNA ligase 3, BRCT domain", "go_ids": [], "go_terms": [], "name": "LIG3_BRCT", "pathway_ids": ["R-DRE-5696395", "R-HSA-110381", "R-MMU-5649702", "R-HSA-5696397", "R-HSA-6782210", "R-MMU-5685939", "R-DRE-5696400", "R-MMU-6782210", "R-MMU-110381", "R-DDI-5649702", "R-HSA-5685939", "R-HSA-5649702", "R-DDI-110381", "R-HSA-9913635"], "pathways": ["R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DDI-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DDI-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR031917": {"description": "Pilus assembly protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Pilus_assem_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031918": {"description": "Herpesvirus membrane glycoprotein UL141", "go_ids": [], "go_terms": [], "name": "UL141", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Family"}, "IPR031919": {"description": "Alpha-L-fucosidase, C-terminal", "go_ids": [], "go_terms": [], "name": "Fucosidase_C", "pathway_ids": ["PWY-6807", "R-DDI-6798695", "R-HSA-6798695", "R-DME-381426", "R-DDI-975578", "R-DME-8957275", "R-HSA-975578", "R-DME-6798695", "R-BTA-6798695", "R-BTA-975578", "R-MMU-8957275", "R-RNO-381426", "R-DME-975578", "R-RNO-8957275", "R-MMU-381426", "R-MMU-6798695", "R-RNO-975578", "R-HSA-8957275", "R-MMU-975578", "R-HSA-381426", "R-RNO-6798695"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DDI-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR031920": {"description": "Partner and localiser of BRCA2, WD40 domain", "go_ids": [], "go_terms": [], "name": "PALB2_WD40", "pathway_ids": ["R-HSA-5685942", "R-HSA-9704331", "R-HSA-5693579", "R-HSA-8951664", "R-HSA-9704646", "R-MMU-5693568", "R-HSA-9755511", "R-MMU-5685942", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-9709603", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-8951664:r:Neddylation", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR031922": {"description": "Pesticin, C-terminal", "go_ids": ["GO:0003796"], "go_terms": ["GO:0003796:lysozyme activity:F"], "name": "Pesticin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031923": {"description": "Helicobacter TNF-alpha-inducing protein", "go_ids": [], "go_terms": [], "name": "Tipalpha", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031924": {"description": "Glycosyl hydrolase family 115", "go_ids": [], "go_terms": [], "name": "GH115", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031925": {"description": "Tubulin-specific chaperone C, N-terminal", "go_ids": ["GO:0015631"], "go_terms": ["GO:0015631:tubulin binding:F"], "name": "TBCC_N", "pathway_ids": ["R-HSA-389977"], "pathways": ["R-HSA-389977:r:Post-chaperonin tubulin folding pathway"], "type": "Domain"}, "IPR031926": {"description": "Transmembrane protein 135, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TMEM135_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031927": {"description": "Domain of unknown function DUF4767", "go_ids": [], "go_terms": [], "name": "DUF4767", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031928": {"description": "Anti-sigma-D factor RsdA, sigma factor binding region", "go_ids": [], "go_terms": [], "name": "RsdA_SigD-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031929": {"description": "Bacterial collagen-like protein, middle domain", "go_ids": [], "go_terms": [], "name": "CLP_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031930": {"description": "Two-component histidine kinase, sensor domain", "go_ids": [], "go_terms": [], "name": "HK_sensor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031931": {"description": "Protein of unknown function DUF4768", "go_ids": [], "go_terms": [], "name": "DUF4768", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031932": {"description": "Arterivirus nonstructural protein 7 alpha", "go_ids": [], "go_terms": [], "name": "Arteri_nsp7a", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR031933": {"description": "UPF0767 family", "go_ids": [], "go_terms": [], "name": "UPF0767", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031934": {"description": "Protein of unknown function DUF4769", "go_ids": [], "go_terms": [], "name": "DUF4769", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031935": {"description": "Domain of unknown function DUF4770", "go_ids": [], "go_terms": [], "name": "DUF4770", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031936": {"description": "Domain of unknown function DUF4771", "go_ids": [], "go_terms": [], "name": "DUF4771", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031937": {"description": "PNN-interacting serine/arginine-rich protein", "go_ids": [], "go_terms": [], "name": "PNISR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031938": {"description": "Protein inscuteable homologue, LGN-binding domain", "go_ids": [], "go_terms": [], "name": "INSC_LBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031939": {"description": "Surface-adhesin protein E-like", "go_ids": [], "go_terms": [], "name": "Adhesin_E-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031940": {"description": "ZNF395/ZNF704, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ZNF395/ZNF704_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031941": {"description": "Domain of unknown function DUF4773", "go_ids": [], "go_terms": [], "name": "DUF4773", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031942": {"description": "Domain of unknown function DUF4774", "go_ids": [], "go_terms": [], "name": "DUF4774", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031943": {"description": "CARMIL, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CARMIL_C", "pathway_ids": ["R-HSA-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR031944": {"description": "Ribosome biogenesis GTPase RsgA, N-terminal", "go_ids": [], "go_terms": [], "name": "RsgA_N", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR031945": {"description": "Protein of unknown function DUF4775", "go_ids": [], "go_terms": [], "name": "DUF4775", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031946": {"description": "KIAA1045, RING finger", "go_ids": [], "go_terms": [], "name": "KIAA1045_Zf_RING", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031947": {"description": "Headcase, middle domain", "go_ids": [], "go_terms": [], "name": "Headcase_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031948": {"description": "Periplasmic lysozyme inhibitor, I-type", "go_ids": [], "go_terms": [], "name": "PliI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031949": {"description": "Domain of unknown function DUF4776", "go_ids": [], "go_terms": [], "name": "DUF4776", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031950": {"description": "116kDa U5 small nuclear ribonucleoprotein component, N-terminal", "go_ids": [], "go_terms": [], "name": "EFTUD2_N", "pathway_ids": ["R-HSA-72165", "R-HSA-72163", "R-SPO-72163", "R-MMU-72165", "R-HSA-9918481", "R-MMU-72163"], "pathways": ["R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR031951": {"description": "Interleukin 17 receptor D, N-terminal", "go_ids": [], "go_terms": [], "name": "IL17R_D_N", "pathway_ids": ["R-HSA-5674135", "R-MMU-5674135", "R-DRE-5674135"], "pathways": ["R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-DRE-5674135:r:MAP2K and MAPK activation"], "type": "Domain"}, "IPR031952": {"description": "KH-like RNA-binding domain", "go_ids": [], "go_terms": [], "name": "MOEP19_KH-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031953": {"description": "mRNA-decapping enzyme, C-terminal", "go_ids": [], "go_terms": [], "name": "mRNA_decap_C", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-HSA-975957", "R-MMU-450513", "R-MMU-430039", "R-CEL-450385", "R-HSA-450513", "R-MMU-975957", "R-CEL-430039", "R-CEL-450513", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR031957": {"description": "Domain of unknown function DUF4777", "go_ids": [], "go_terms": [], "name": "DUF4777", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031958": {"description": "Protein of unknown function DUF4778", "go_ids": [], "go_terms": [], "name": "DUF4778", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031959": {"description": "Protein of unknown function DUF4779", "go_ids": [], "go_terms": [], "name": "DUF4779", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031961": {"description": "Domain of unknown function DUF4780", "go_ids": [], "go_terms": [], "name": "DUF4780", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031962": {"description": "Domain of unknown function DUF4781", "go_ids": [], "go_terms": [], "name": "DUF4781", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031963": {"description": "Histone deacetylase complex subunit SAP130, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SAP130_C", "pathway_ids": ["R-HSA-3214847", "R-HSA-427413"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones", "R-HSA-427413:r:NoRC negatively regulates rRNA expression"], "type": "Domain"}, "IPR031964": {"description": "Caspase recruitment domain", "go_ids": [], "go_terms": [], "name": "CARD_dom", "pathway_ids": ["R-HSA-9833109", "R-MMU-9909505", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9920588", "R-HSA-5689896", "R-HSA-5689880", "R-HSA-9833482", "R-HSA-933542", "R-HSA-936440", "R-HSA-1169408", "R-HSA-9909505", "R-MMU-5689880", "R-HSA-918233", "R-MMU-9833482", "R-HSA-9833110", "R-MMU-8983711", "R-HSA-8983711", "R-MMU-168928", "R-MMU-1169408", "R-HSA-933541", "R-HSA-933543", "R-HSA-9692916", "R-RNO-936440", "R-MMU-936440", "R-RNO-168928", "R-RNO-9833482"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-8983711:r:OAS antiviral response", "R-HSA-8983711:r:OAS antiviral response", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-RNO-9833482:r:PKR-mediated signaling"], "type": "Domain"}, "IPR031965": {"description": "Starch-binding module 26", "go_ids": [], "go_terms": [], "name": "CBM26", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031966": {"description": "PHD finger protein 12, MRG binding domain", "go_ids": [], "go_terms": [], "name": "PHF12_MRG-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031967": {"description": "PhoR, single Cache-like domain", "go_ids": [], "go_terms": [], "name": "PhoR_single_Cache-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031968": {"description": "VASt domain", "go_ids": [], "go_terms": [], "name": "VASt", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031970": {"description": "Anillin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Anillin_N", "pathway_ids": ["R-HSA-9013026", "R-HSA-8980692", "R-HSA-9013106", "R-MMU-9013106", "R-MMU-9013026", "R-MMU-8980692"], "pathways": ["R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Domain"}, "IPR031971": {"description": "Unconventional myosin-X, coiled coil domain", "go_ids": [], "go_terms": [], "name": "MYO10_CC", "pathway_ids": ["R-HSA-2029482", "R-HSA-373752", "R-HSA-9664422", "R-MMU-2029482", "R-RNO-2029482"], "pathways": ["R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation"], "type": "Domain"}, "IPR031972": {"description": "Cysteine/serine-rich nuclear protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CSRNP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031973": {"description": "Deltamethrin resistance protein prag01", "go_ids": [], "go_terms": [], "name": "Deltameth_res_prag01", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031974": {"description": "Programmed cell death protein 7", "go_ids": [], "go_terms": [], "name": "PDCD7", "pathway_ids": ["R-MMU-72165", "R-HSA-72165"], "pathways": ["R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway"], "type": "Family"}, "IPR031975": {"description": "Type IV pilin-like putative secretion pathway protein G/H", "go_ids": [], "go_terms": [], "name": "Pilin_GH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031976": {"description": "Rhomboid protease, N-terminal", "go_ids": [], "go_terms": [], "name": "NRho", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031977": {"description": "Protein of unknown function DUF4783", "go_ids": [], "go_terms": [], "name": "DUF4783", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031978": {"description": "Domain of unknown function DUF4784", "go_ids": [], "go_terms": [], "name": "DUF4784", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031979": {"description": "DUF4785, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF4785_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031981": {"description": "Mitochondria-eating protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MIEAP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031982": {"description": "Type IV pilus non-core minor pilin PilE-like", "go_ids": ["GO:0043683"], "go_terms": ["GO:0043683:type IV pilus assembly:P"], "name": "PilE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031983": {"description": "Protein of unknown function DUF4786", "go_ids": [], "go_terms": [], "name": "DUF4786", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031984": {"description": "Solute carrier family 3 member 2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SLC3A2_N", "pathway_ids": ["R-HSA-71240", "R-HSA-352230", "R-RNO-352230", "R-RNO-210991", "R-HSA-5660862", "R-MMU-210991", "R-MMU-71240", "R-RNO-71240", "R-HSA-210991", "R-MMU-352230"], "pathways": ["R-HSA-71240:r:Tryptophan catabolism", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-RNO-210991:r:Basigin interactions", "R-HSA-5660862:r:Defective SLC7A7 causes lysinuric protein intolerance (LPI)", "R-MMU-210991:r:Basigin interactions", "R-MMU-71240:r:Tryptophan catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-HSA-210991:r:Basigin interactions", "R-MMU-352230:r:Amino acid transport across the plasma membrane"], "type": "Domain"}, "IPR031985": {"description": "Protein of unknown function DUF4787", "go_ids": [], "go_terms": [], "name": "DUF4787", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031986": {"description": "Serine protease gd, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GD_N", "pathway_ids": ["R-DME-209442"], "pathways": ["R-DME-209442:r:Formation of the trans-membrane 'signalling complex'"], "type": "Domain"}, "IPR031987": {"description": "Trypanosoma glutamic acid/alanine-rich protein", "go_ids": [], "go_terms": [], "name": "GARP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031988": {"description": "DNA primase DnaG, C-terminal helicase-binding domain", "go_ids": [], "go_terms": [], "name": "DnaG_HBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031989": {"description": "Domain of unknown function DUF5067", "go_ids": [], "go_terms": [], "name": "DUF5067", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031990": {"description": "Protein of unknown function DUF5066", "go_ids": [], "go_terms": [], "name": "DUF5066", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031991": {"description": "DNA repair protein Rev1, C-terminal", "go_ids": [], "go_terms": [], "name": "Rev1_C", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-MMU-5655862", "R-GGA-5656121", "R-SPO-5656169", "R-SPO-5656121", "R-SPO-5655862", "R-MMU-5656169", "R-HSA-5656169", "R-MMU-110312", "R-SPO-110312", "R-DME-5656121", "R-HSA-110312", "R-GGA-5655862", "R-HSA-5655862", "R-GGA-353503", "R-GGA-110312", "R-GGA-5656169", "R-MMU-5656121", "R-DME-5655862", "R-DME-110312", "R-HSA-5656121"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-DME-5656121:r:Translesion synthesis by POLI", "R-HSA-110312:r:Translesion synthesis by REV1", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-GGA-353503:r:Translesion synthesis by Pol kappa", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-5656121:r:Translesion synthesis by POLI"], "type": "Domain"}, "IPR031992": {"description": "Domain of unknown function DUF4788", "go_ids": [], "go_terms": [], "name": "DUF4788", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031993": {"description": "Domain of unknown function DUF4789", "go_ids": [], "go_terms": [], "name": "DUF4789", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031994": {"description": "Janus kinase and microtubule-interacting protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "JAKMIP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031995": {"description": "Inositol polyphosphate 5-phosphatase, clathrin binding domain", "go_ids": [], "go_terms": [], "name": "OCRL_clath-bd", "pathway_ids": ["PWY-6368", "PWY-6363", "PWY-6362", "PWY-6364", "R-HSA-9013409", "R-MMU-8856828", "R-RNO-9013409", "R-HSA-8856828", "R-MMU-432722", "R-MMU-9013409", "R-HSA-1660514", "R-HSA-1660499", "R-RNO-1660514", "R-MMU-1660499", "R-RNO-9013423", "R-HSA-9013423", "R-MMU-9013423", "R-RNO-1660499", "R-HSA-1855204", "R-RNO-1855204", "R-HSA-1855183", "R-MMU-1660514", "R-RNO-8856828", "R-MMU-1855183", "R-MMU-1855204", "R-HSA-432722", "R-RNO-432722", "R-RNO-1855183"], "pathways": ["PWY-6368:t:3-phosphoinositide degradation", "PWY-6363:t:D-myo-inositol (1,4,5)-trisphosphate degradation", "PWY-6362:t:1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)", "PWY-6364:t:D-myo-inositol (1,3,4)-trisphosphate biosynthesis", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol"], "type": "Domain"}, "IPR031996": {"description": "NVL2, nucleolin binding domain", "go_ids": [], "go_terms": [], "name": "NVL2_nucleolin-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR031997": {"description": "Myoviridae tail sheath stabiliser", "go_ids": [], "go_terms": [], "name": "T4-gp15_tss", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031998": {"description": "Protein of unknown function DUF5065", "go_ids": [], "go_terms": [], "name": "DUF5065", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR031999": {"description": "Pathogenicity island protein gp6, Staphylococcus", "go_ids": [], "go_terms": [], "name": "SAPIS-gp6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032000": {"description": "Albumin I chain a", "go_ids": [], "go_terms": [], "name": "Albumin_I_a", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032001": {"description": "SAWADEE domain", "go_ids": ["GO:0003682"], "go_terms": ["GO:0003682:chromatin binding:F"], "name": "SAWADEE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032002": {"description": "Immunity factor for SPN", "go_ids": [], "go_terms": [], "name": "IFS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032003": {"description": "Ribosome-associated complex head domain", "go_ids": [], "go_terms": [], "name": "RAC_head", "pathway_ids": ["R-SCE-3371453", "R-XTR-3371453", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-DRE-3371453", "R-BTA-3371453", "R-MMU-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR032004": {"description": "Protein of unknown function DUF4790", "go_ids": [], "go_terms": [], "name": "DUF4790", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032005": {"description": "Tyrosyl-tRNA synthetase, C-terminal", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "TyrRSs_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032006": {"description": "Transmembrane inner ear expressed protein", "go_ids": [], "go_terms": [], "name": "TMIE", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Family"}, "IPR032007": {"description": "Protein of unknown function DUF4791", "go_ids": [], "go_terms": [], "name": "DUF4791", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032008": {"description": "E3 ubiquitin-protein ligase APD1-4, N-terminal", "go_ids": [], "go_terms": [], "name": "APD1-4_N", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR032009": {"description": "Stomatal closure-related actin-binding protein, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "SCAB_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032010": {"description": "E3 ubiquitin-protein ligase APD1-4, middle domain", "go_ids": [], "go_terms": [], "name": "APD1-4_M", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR032011": {"description": "Domain of unknown function DUF4794", "go_ids": [], "go_terms": [], "name": "DUF4794", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032012": {"description": "Stomatal closure-related actin-binding protein, actin-binding domain", "go_ids": ["GO:0003779"], "go_terms": ["GO:0003779:actin binding:F"], "name": "SCAB-ABD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032013": {"description": "Domain of unknown function DUF4795", "go_ids": [], "go_terms": [], "name": "DUF4795", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032014": {"description": "Vibrio phage CTXphi pIII, N-terminal N1 domain", "go_ids": [], "go_terms": [], "name": "CTXphi_pIII-N1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032015": {"description": "Stomatal closure-related actin-binding protein, Ig domain", "go_ids": [], "go_terms": [], "name": "SCAB-Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032016": {"description": "MKRN2 opposite strand protein-like", "go_ids": [], "go_terms": [], "name": "MKRN2OS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032017": {"description": "FAM76 protein", "go_ids": [], "go_terms": [], "name": "FAM76", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032018": {"description": "Putative lipoprotein, pathogenic bacteria", "go_ids": [], "go_terms": [], "name": "LppA/LppB/LprP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032019": {"description": "Frog antimicrobial peptide, ranacyclin-type, Ranidae", "go_ids": ["GO:0005576", "GO:0006952"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006952:defense response:P"], "name": "Frog_antimicrobial_Ranidae", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032020": {"description": "CAG pathogenicity island protein 13", "go_ids": [], "go_terms": [], "name": "CagS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032021": {"description": "Frog antimicrobial peptide, caerin-type, Litoria", "go_ids": ["GO:0006952", "GO:0005576"], "go_terms": ["GO:0006952:defense response:P", "GO:0005576:extracellular region:C"], "name": "Frog_Litoria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032022": {"description": "KRIT, N-terminal NPxY motif-rich region", "go_ids": [], "go_terms": [], "name": "NUDIX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032023": {"description": "GCC2, Rab binding domain", "go_ids": [], "go_terms": [], "name": "GCC2_Rab_bind", "pathway_ids": ["R-HSA-9725370", "R-HSA-6811440", "R-RNO-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR032024": {"description": "Protein of unknown function DUF5064", "go_ids": [], "go_terms": [], "name": "DUF5064", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032025": {"description": "Protein of unknown function DUF5063", "go_ids": [], "go_terms": [], "name": "DUF5063", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032026": {"description": "Adenylate cyclase regulatory domain", "go_ids": [], "go_terms": [], "name": "Ad_Cy_reg", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032027": {"description": "Synphilin-1, alpha-Synuclein-binding domain", "go_ids": [], "go_terms": [], "name": "SNCAIP_SNCA-bd", "pathway_ids": ["R-HSA-977225"], "pathways": ["R-HSA-977225:r:Amyloid fiber formation"], "type": "Domain"}, "IPR032028": {"description": "Cleavage stimulation factor subunit 1, dimerisation domain", "go_ids": [], "go_terms": [], "name": "CSTF1_dimer", "pathway_ids": ["R-RNO-73856", "R-HSA-77595", "R-MMU-72187", "R-HSA-9770562", "R-MMU-9770562", "R-RNO-9770562", "R-MMU-77595", "R-HSA-73856", "R-RNO-77595", "R-MMU-73856", "R-HSA-72187", "R-HSA-9918481"], "pathways": ["R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR032029": {"description": "ADAM17, membrane-proximal domain", "go_ids": [], "go_terms": [], "name": "ADAM17_MPD", "pathway_ids": ["R-MMU-193692", "R-HSA-5362798", "R-RNO-193692", "R-HSA-2122948", "R-HSA-2660826", "R-HSA-9662834", "R-RNO-75893", "R-HSA-1251985", "R-HSA-177929", "R-HSA-2894862", "R-HSA-2644606", "R-HSA-2691232", "R-HSA-75893", "R-HSA-193692", "R-HSA-1442490", "R-HSA-982772", "R-MMU-75893"], "pathways": ["R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-RNO-75893:r:TNF signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-75893:r:TNF signaling", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-1442490:r:Collagen degradation", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-75893:r:TNF signaling"], "type": "Domain"}, "IPR032030": {"description": "YscD, cytoplasmic domain", "go_ids": [], "go_terms": [], "name": "YscD_cytoplasmic_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032031": {"description": "Zinc finger FYVE domain-containing protein 21, C-terminal", "go_ids": [], "go_terms": [], "name": "ZFYVE21_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032032": {"description": "Type VI secretion system (T6SS), amidase immunity protein", "go_ids": [], "go_terms": [], "name": "Tai4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032033": {"description": "Cytochrome P460", "go_ids": [], "go_terms": [], "name": "Cytochrome_P460", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032034": {"description": "YscD-like, Bon-like domain 1", "go_ids": [], "go_terms": [], "name": "YscD_ppl_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032035": {"description": "Folliculin, DENN domain", "go_ids": [], "go_terms": [], "name": "Folliculin_DENN", "pathway_ids": ["R-RNO-9639288", "R-MMU-9639288", "R-HSA-9639288", "R-XTR-9639288", "R-BTA-9639288"], "pathways": ["R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-BTA-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR032036": {"description": "Protein of unknown function DUF5062", "go_ids": [], "go_terms": [], "name": "DUF5062", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032037": {"description": "Methylmalonic aciduria and homocystinuria type C family", "go_ids": [], "go_terms": [], "name": "MMACHC", "pathway_ids": ["PWY-7974", "R-HSA-9759218", "R-DRE-9759218", "R-HSA-3359474", "R-BTA-9759218", "R-HSA-3359473", "R-CEL-9759218", "R-MMU-9759218"], "pathways": ["PWY-7974:t:cobalamin salvage (eukaryotic)", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-DRE-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-3359474:r:Defective MMACHC causes MAHCC", "R-BTA-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-3359473:r:Defective MMADHC causes MMAHCD", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism"], "type": "Family"}, "IPR032038": {"description": "Adenomatous polyposis coli, N-terminal dimerisation domain", "go_ids": [], "go_terms": [], "name": "APC_N", "pathway_ids": ["R-HSA-5358751", "R-HSA-5358752", "R-HSA-5358749", "R-MMU-3769402", "R-MMU-196299", "R-HSA-3769402", "R-RNO-4641262", "R-HSA-5689896", "R-HSA-5467348", "R-MMU-5689896", "R-HSA-196299", "R-HSA-5467340", "R-RNO-111465", "R-HSA-5358747", "R-RNO-196299", "R-HSA-5339716", "R-HSA-5467337", "R-MMU-4641262", "R-HSA-4641262", "R-HSA-111465", "R-MMU-111465", "R-RNO-3769402", "R-RNO-5689896", "R-HSA-5467333", "R-RNO-195253", "R-MMU-195253", "R-HSA-195253"], "pathways": ["R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467333:r:APC truncation mutants are not K63 polyubiquitinated", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Domain"}, "IPR032039": {"description": "Alphacoronavirus nsp1", "go_ids": [], "go_terms": [], "name": "A-CoV_nsp1", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Domain"}, "IPR032040": {"description": "ELYS, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "ELYS-bb", "pathway_ids": ["R-MMU-2500257", "R-HSA-9615933", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-68877", "R-MMU-2467813", "R-HSA-141444", "R-HSA-5663220", "R-MMU-68877", "R-MMU-9648025", "R-HSA-9648025", "R-MMU-5663220", "R-MMU-9615933"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation"], "type": "Domain"}, "IPR032041": {"description": "Paf1 complex subunit Cdc73, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Cdc73_N", "pathway_ids": ["R-MMU-8866654", "R-RNO-5632684", "R-MMU-5632684", "R-CEL-75955", "R-RNO-674695", "R-RNO-201722", "R-HSA-9920588", "R-RNO-75955", "R-MMU-201722", "R-CEL-201722", "R-RNO-8866654", "R-HSA-5632684", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695", "R-HSA-8866654", "R-CEL-674695", "R-HSA-201722", "R-RNO-112382", "R-HSA-75955", "R-CEL-112382", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-5632684:r:Hedgehog 'on' state", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR032042": {"description": "Protection of telomeres protein 1, ssDNA-binding domain", "go_ids": ["GO:0043047"], "go_terms": ["GO:0043047:single-stranded telomeric DNA binding:F"], "name": "POT1PC", "pathway_ids": ["R-GGA-174417", "R-MMU-174430", "R-MMU-110330", "R-HSA-171306", "R-HSA-174414", "R-GGA-174437", "R-MMU-2559586", "R-GGA-174411", "R-MMU-174417", "R-HSA-174430", "R-HSA-110328", "R-GGA-174414", "R-GGA-174430", "R-HSA-1221632", "R-HSA-174411", "R-MMU-110331", "R-MMU-9670095", "R-MMU-171319", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-GGA-418124", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-GGA-171319", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-GGA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-GGA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-GGA-174414:r:Processive synthesis on the C-strand of the telomere", "R-GGA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-GGA-418124:r:Telomere maintenance", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-GGA-171319:r:Telomere Extension By Telomerase", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Domain"}, "IPR032043": {"description": "E3 ubiquitin-protein ligase Msl2, zinc RING finger", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "Msl2_Znf-RING", "pathway_ids": ["PWY-7511", "R-MMU-3214847", "R-HSA-3214847", "R-DME-3214847", "R-GGA-3214847"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-GGA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR032047": {"description": "Telomere resolvase ResT/TelK, catalytic domain", "go_ids": [], "go_terms": [], "name": "ResT/TelK_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032048": {"description": "Transglutaminase elicitor", "go_ids": ["GO:0016755"], "go_terms": ["GO:0016755:aminoacyltransferase activity:F"], "name": "TGase_elicitor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032049": {"description": "E3 ubiquitin-protein ligase Msl2, CXC domain", "go_ids": [], "go_terms": [], "name": "Msl2-CXC", "pathway_ids": ["PWY-7511", "R-MMU-3214847", "R-HSA-3214847", "R-DME-3214847", "R-GGA-3214847"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-GGA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR032050": {"description": "Domain of unknown function DUF4797", "go_ids": [], "go_terms": [], "name": "DUF4797", "pathway_ids": ["R-DME-429947"], "pathways": ["R-DME-429947:r:Deadenylation of mRNA"], "type": "Domain"}, "IPR032052": {"description": "CD3 gamma/delta subunit, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_4", "pathway_ids": ["R-MMU-8856828", "R-SSC-202427", "R-MMU-8856825", "R-HSA-202433", "R-HSA-8856828", "R-BTA-202424", "R-BTA-202427", "R-SSC-198933", "R-HSA-2029485", "R-RNO-202433", "R-HSA-2029481", "R-MMU-202430", "R-RNO-2029482", "R-HSA-202427", "R-RNO-2029485", "R-RNO-202427", "R-SSC-202433", "R-RNO-202424", "R-MMU-2029485", "R-RNO-8856828", "R-SSC-2029482", "R-SSC-8856825", "R-HSA-202430", "R-MMU-202424", "R-SSC-2029481", "R-BTA-8856828", "R-MMU-389948", "R-MMU-202433", "R-BTA-202430", "R-BTA-198933", "R-RNO-8856825", "R-RNO-198933", "R-RNO-2029481", "R-HSA-2029482", "R-SSC-2029485", "R-MMU-2029482", "R-MMU-2029481", "R-SSC-202424", "R-BTA-8856825", "R-BTA-389948", "R-MMU-198933", "R-SSC-202430", "R-SSC-8856828", "R-HSA-202424", "R-HSA-8856825", "R-RNO-389948", "R-SSC-389948", "R-HSA-198933", "R-MMU-202427", "R-RNO-202430", "R-HSA-9664422", "R-HSA-389948", "R-BTA-202433", "R-HSA-9664323"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SSC-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-202433:r:Generation of second messenger molecules", "R-HSA-2029481:r:FCGR activation", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-202433:r:Generation of second messenger molecules", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-202424:r:Downstream TCR signaling", "R-SSC-2029481:r:FCGR activation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-202433:r:Generation of second messenger molecules", "R-BTA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-2029481:r:FCGR activation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SSC-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029481:r:FCGR activation", "R-SSC-202424:r:Downstream TCR signaling", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-389948:r:Co-inhibition by PD-1", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-SSC-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-389948:r:Co-inhibition by PD-1", "R-SSC-389948:r:Co-inhibition by PD-1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-389948:r:Co-inhibition by PD-1", "R-BTA-202433:r:Generation of second messenger molecules", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis"], "type": "Domain"}, "IPR032053": {"description": "Small ribosomal subunit protein mS34", "go_ids": ["GO:0003735", "GO:0005739"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005739:mitochondrion:C"], "name": "Ribosomal_mS34", "pathway_ids": ["R-MMU-5419276", "R-MMU-9937383", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Family"}, "IPR032054": {"description": "DNA replication factor Cdt1, C-terminal", "go_ids": [], "go_terms": [], "name": "Cdt1_C", "pathway_ids": ["R-MMU-68867", "R-HSA-68949", "R-HSA-69052", "R-HSA-69205", "R-MMU-68962", "R-HSA-68962", "R-SPO-68962", "R-MMU-68949", "R-SPO-68949", "R-MMU-69052", "R-HSA-68867"], "pathways": ["R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-SPO-68949:r:Orc1 removal from chromatin", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR032055": {"description": "Transmembrane protein 72", "go_ids": [], "go_terms": [], "name": "TMEM72", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032056": {"description": "Protein of unknown function DUF4798", "go_ids": [], "go_terms": [], "name": "DUF4798", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032057": {"description": "Protein of unknown function DUF4799", "go_ids": [], "go_terms": [], "name": "DUF4799", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032059": {"description": "Mucin-like domain", "go_ids": [], "go_terms": [], "name": "Mucin-like", "pathway_ids": ["R-HSA-192456", "R-HSA-9925561"], "pathways": ["R-HSA-192456:r:Digestion of dietary lipid", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells"], "type": "Domain"}, "IPR032060": {"description": "MGA, conserved domain", "go_ids": [], "go_terms": [], "name": "MGA_dom", "pathway_ids": ["R-HSA-8953750", "R-MMU-8953750"], "pathways": ["R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-8953750:r:Transcriptional Regulation by E2F6"], "type": "Domain"}, "IPR032061": {"description": "Domain of unknown function DUF4802", "go_ids": [], "go_terms": [], "name": "DUF4802", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032062": {"description": "Protein of unknown function DUF4803", "go_ids": [], "go_terms": [], "name": "DUF4803", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032063": {"description": "ADP-ribosylhydrolase MavL-like", "go_ids": [], "go_terms": [], "name": "MavL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032064": {"description": "Protein of unknown function DUF4805", "go_ids": [], "go_terms": [], "name": "DUF4805", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032065": {"description": "E3 ubiquitin-protein ligase RNF31, UBA-like domain", "go_ids": [], "go_terms": [], "name": "RNF31-UBA", "pathway_ids": ["R-MMU-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357956", "R-HSA-5357786", "R-MMU-5357905"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling"], "type": "Domain"}, "IPR032066": {"description": "DNA-packaging protein gp3", "go_ids": [], "go_terms": [], "name": "GP3_package", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032067": {"description": "FOXO protein, transactivation domain", "go_ids": [], "go_terms": [], "name": "FOXO-TAD", "pathway_ids": ["R-MMU-9614399", "R-HSA-9607240", "R-RNO-198693", "R-XTR-211163", "R-MMU-9607240", "R-HSA-5689880", "R-HSA-198693", "R-DRE-9614399", "R-HSA-8862803", "R-RNO-5687128", "R-HSA-9617828", "R-HSA-8952158", "R-MMU-9617629", "R-HSA-9614399", "R-MMU-5689880", "R-HSA-1181150", "R-HSA-9615017", "R-MMU-211163", "R-DRE-211163", "R-MMU-198693", "R-HSA-9614657", "R-DRE-9617828", "R-HSA-9617629", "R-HSA-211163", "R-MMU-9617828", "R-DRE-198693", "R-DRE-5687128", "R-MMU-9615017", "R-HSA-5674400", "R-HSA-9841251", "R-HSA-210745", "R-RNO-9614399", "R-HSA-6785807", "R-HSA-9634638", "R-HSA-5687128", "R-MMU-9841251", "R-HSA-9733709", "R-XTR-9617828", "R-RNO-9617828", "R-MMU-9634638", "R-RNO-9617629", "R-RNO-211163", "R-MMU-5687128", "R-XTR-9614399", "R-MMU-1181150"], "pathways": ["R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-198693:r:AKT phosphorylates targets in the nucleus", "R-XTR-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-9607240:r:FLT3 Signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-DRE-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-1181150:r:Signaling by NODAL", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-211163:r:AKT-mediated inactivation of FOXO1A", "R-DRE-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-DRE-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DRE-198693:r:AKT phosphorylates targets in the nucleus", "R-DRE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-RNO-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-9733709:r:Cardiogenesis", "R-XTR-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-RNO-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-1181150:r:Signaling by NODAL"], "type": "Domain"}, "IPR032068": {"description": "FOXO protein, KIX-binding domain", "go_ids": [], "go_terms": [], "name": "FOXO_KIX-bd", "pathway_ids": ["R-MMU-9614399", "R-HSA-9607240", "R-RNO-198693", "R-XTR-211163", "R-MMU-9607240", "R-HSA-198693", "R-DRE-9614399", "R-HSA-8862803", "R-RNO-5687128", "R-HSA-9617828", "R-HSA-8952158", "R-MMU-9617629", "R-HSA-9614399", "R-HSA-1181150", "R-HSA-9615017", "R-MMU-211163", "R-DRE-211163", "R-MMU-198693", "R-HSA-9614657", "R-DRE-9617828", "R-HSA-9617629", "R-HSA-211163", "R-MMU-9617828", "R-DRE-198693", "R-DRE-5687128", "R-HSA-5674400", "R-HSA-9841251", "R-HSA-210745", "R-RNO-9614399", "R-HSA-6785807", "R-HSA-9634638", "R-HSA-5687128", "R-MMU-9841251", "R-XTR-9617828", "R-RNO-9617828", "R-MMU-9634638", "R-RNO-9617629", "R-RNO-211163", "R-MMU-5687128", "R-XTR-9614399", "R-MMU-1181150"], "pathways": ["R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-9607240:r:FLT3 Signaling", "R-RNO-198693:r:AKT phosphorylates targets in the nucleus", "R-XTR-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-9607240:r:FLT3 Signaling", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-DRE-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-1181150:r:Signaling by NODAL", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-211163:r:AKT-mediated inactivation of FOXO1A", "R-DRE-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-DRE-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DRE-198693:r:AKT phosphorylates targets in the nucleus", "R-DRE-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-RNO-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-XTR-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-RNO-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-1181150:r:Signaling by NODAL"], "type": "Domain"}, "IPR032069": {"description": "Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain", "go_ids": [], "go_terms": [], "name": "USP37-like_PH", "pathway_ids": ["R-MMU-5689880", "R-DRE-5689880", "R-BTA-5689880", "R-HSA-5689880", "R-CFA-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CFA-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR032070": {"description": "TNF receptor-associated factor, BIRC3 binding domain", "go_ids": [], "go_terms": [], "name": "TRAF_BIRC3-bd", "pathway_ids": ["R-MMU-5357786", "R-MMU-5676594", "R-HSA-5218900", "R-HSA-5689880", "R-HSA-933542", "R-HSA-5675482", "R-MMU-5675482", "R-HSA-5676594", "R-HSA-9758274", "R-HSA-75893", "R-MMU-5357956", "R-HSA-5357786", "R-HSA-69416", "R-HSA-5213460", "R-MMU-5689880", "R-HSA-5668541", "R-MMU-69416", "R-HSA-933541", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5668541", "R-MMU-5357905", "R-HSA-9693928", "R-MMU-5218900", "R-MMU-3371378", "R-HSA-140534", "R-MMU-9758274", "R-HSA-3371378", "R-MMU-75893"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-75893:r:TNF signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-69416:r:Dimerization of procaspase-8", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-69416:r:Dimerization of procaspase-8", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-MMU-3371378:r:Regulation by c-FLIP", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-3371378:r:Regulation by c-FLIP", "R-MMU-75893:r:TNF signaling"], "type": "Domain"}, "IPR032071": {"description": "Domain of unknown function DUF4806", "go_ids": [], "go_terms": [], "name": "DUF4806", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032072": {"description": "Protein of unknown function DUF4807", "go_ids": [], "go_terms": [], "name": "DUF4807", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032073": {"description": "Fibronectin type III domain-containing protein 5, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FNDC5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032074": {"description": "Actin cross-linking domain", "go_ids": ["GO:0007015"], "go_terms": ["GO:0007015:actin filament organization:P"], "name": "ACD_dom", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis"], "type": "Domain"}, "IPR032075": {"description": "Phosphoinositide phospholipase C, Ca2+-dependent", "go_ids": [], "go_terms": [], "name": "PI-PLC-C1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032076": {"description": "Tetratricopeptide repeat protein 5, OB fold domain", "go_ids": [], "go_terms": [], "name": "TTC5_OB", "pathway_ids": ["R-HSA-6804760", "R-BTA-6804760", "R-MMU-6804760", "R-RNO-6804760"], "pathways": ["R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation"], "type": "Domain"}, "IPR032077": {"description": "Adhesin JlpA, Campylobacter", "go_ids": ["GO:0007155"], "go_terms": ["GO:0007155:cell adhesion:P"], "name": "JLPA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032078": {"description": "Multiple PDZ domain protein, unstructured region", "go_ids": [], "go_terms": [], "name": "MPDZ_u10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032080": {"description": "Protein of unknown function DUF4809", "go_ids": [], "go_terms": [], "name": "DUF4809", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032083": {"description": "Protein of unknown function DUF4811", "go_ids": [], "go_terms": [], "name": "DUF4811", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032084": {"description": "Domain of unknown function DUF4812", "go_ids": [], "go_terms": [], "name": "DUF4812", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032086": {"description": "Protein of unknown function DUF4813", "go_ids": [], "go_terms": [], "name": "DUF4813", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032088": {"description": "Starter unit:ACP transacylase, SAT domain", "go_ids": [], "go_terms": [], "name": "SAT", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR032090": {"description": "Peptide chain release factor 3, C-terminal", "go_ids": [], "go_terms": [], "name": "RF3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032091": {"description": "Maltogenic amylase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Malt_amylase-like_C", "pathway_ids": ["R-MTU-868688"], "pathways": ["R-MTU-868688:r:Trehalose biosynthesis"], "type": "Domain"}, "IPR032092": {"description": "Type IV Pilus-assembly protein W", "go_ids": ["GO:0043683"], "go_terms": ["GO:0043683:type IV pilus assembly:P"], "name": "PilW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032093": {"description": "Phospholipase D, N-terminal", "go_ids": [], "go_terms": [], "name": "PhoD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032094": {"description": "Meso-diaminopimelate D-dehydrogenase, C-terminal", "go_ids": [], "go_terms": [], "name": "Meso-DAP_DH_C", "pathway_ids": ["PWY-2942"], "pathways": ["PWY-2942:t:L-lysine biosynthesis III"], "type": "Domain"}, "IPR032095": {"description": "Saccharopine dehydrogenase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Sacchrp_dh-like_C", "pathway_ids": ["R-SCE-71064", "R-MMU-71064", "R-DDI-71064", "R-BTA-71064", "R-RNO-71064", "R-SPO-71064", "R-HSA-71064"], "pathways": ["R-SCE-71064:r:Lysine catabolism", "R-MMU-71064:r:Lysine catabolism", "R-DDI-71064:r:Lysine catabolism", "R-BTA-71064:r:Lysine catabolism", "R-RNO-71064:r:Lysine catabolism", "R-SPO-71064:r:Lysine catabolism", "R-HSA-71064:r:Lysine catabolism"], "type": "Domain"}, "IPR032096": {"description": "Domain of unknown function DUF4815", "go_ids": [], "go_terms": [], "name": "DUF4815", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032098": {"description": "Acyltransferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Acyltransf_C", "pathway_ids": ["PWY-7782", "PWY-5667", "PWY-8053", "PWY-7417", "PWY-7587", "PWY-8051", "PWY-7589", "PWY-6453", "PWY-7411", "PWY-5981", "PWY-8055", "R-SCE-1482798", "R-DRE-1482798", "R-SPO-1482925", "R-RNO-1483166", "R-SCE-1482925", "R-HSA-1483166", "R-HSA-1482925", "R-HSA-1482798", "R-MMU-6811436", "R-MMU-1483166", "R-DRE-1483166", "R-SPO-1483166", "R-SPO-1482798", "R-MMU-1482798", "R-MMU-1482925", "R-SCE-1483166", "R-HSA-6811436"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-5667:t:CDP-diacylglycerol biosynthesis I", "PWY-8053:t:anandamide biosynthesis II", "PWY-7417:t:phospholipid remodeling (phosphatidate, yeast)", "PWY-7587:t:oleate biosynthesis III (cyanobacteria)", "PWY-8051:t:anandamide biosynthesis I", "PWY-7589:t:palmitoleate biosynthesis III (cyanobacteria)", "PWY-6453:t:stigma estolide biosynthesis", "PWY-7411:t:phosphatidate biosynthesis (yeast)", "PWY-5981:t:CDP-diacylglycerol biosynthesis III", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "R-SCE-1482798:r:Acyl chain remodeling of CL", "R-DRE-1482798:r:Acyl chain remodeling of CL", "R-SPO-1482925:r:Acyl chain remodelling of PG", "R-RNO-1483166:r:Synthesis of PA", "R-SCE-1482925:r:Acyl chain remodelling of PG", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-1483166:r:Synthesis of PA", "R-DRE-1483166:r:Synthesis of PA", "R-SPO-1483166:r:Synthesis of PA", "R-SPO-1482798:r:Acyl chain remodeling of CL", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-SCE-1483166:r:Synthesis of PA", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR032100": {"description": "Calpain-3, unstructured region", "go_ids": [], "go_terms": [], "name": "Calpain_u2", "pathway_ids": ["R-HSA-1474228", "R-RNO-1474228", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR032101": {"description": "Axin-1/2, tankyrase-binding domain", "go_ids": [], "go_terms": [], "name": "Axin_TNKS-bd", "pathway_ids": ["R-RNO-201681", "R-HSA-5358751", "R-HSA-5358752", "R-HSA-201681", "R-HSA-5358749", "R-HSA-8931987", "R-MMU-196299", "R-HSA-8939256", "R-RNO-4641262", "R-DRE-195253", "R-HSA-5689880", "R-HSA-5467348", "R-MMU-201681", "R-DRE-4641257", "R-HSA-196299", "R-HSA-5467340", "R-RNO-5689880", "R-DRE-196299", "R-MMU-5689880", "R-RNO-4641257", "R-HSA-5358747", "R-RNO-196299", "R-DRE-4641262", "R-MMU-4641257", "R-HSA-5339716", "R-HSA-5467337", "R-HSA-4641257", "R-HSA-4641262", "R-MMU-4641262", "R-HSA-4411364", "R-RNO-195253", "R-HSA-9018519", "R-MMU-195253", "R-HSA-195253"], "pathways": ["R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-DRE-4641257:r:Degradation of AXIN", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-4641257:r:Degradation of AXIN", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-4641257:r:Degradation of AXIN", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Domain"}, "IPR032103": {"description": "Sodium/hydrogen exchanger, regulatory region", "go_ids": [], "go_terms": [], "name": "NHE_CaM-bd", "pathway_ids": ["R-HSA-425986", "R-BTA-2160916", "R-MMU-425986", "R-RNO-425986", "R-BTA-425986", "R-MMU-2160916", "R-HSA-2160916", "R-RNO-2160916"], "pathways": ["R-HSA-425986:r:Sodium/Proton exchangers", "R-BTA-2160916:r:Hyaluronan degradation", "R-MMU-425986:r:Sodium/Proton exchangers", "R-RNO-425986:r:Sodium/Proton exchangers", "R-BTA-425986:r:Sodium/Proton exchangers", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-2160916:r:Hyaluronan degradation"], "type": "Domain"}, "IPR032104": {"description": "Spaetzle", "go_ids": [], "go_terms": [], "name": "Spaetzle", "pathway_ids": ["R-DME-214842", "R-DME-214874", "R-DME-214844", "R-DME-214863", "R-DME-209442", "R-DME-214869", "R-DME-214862"], "pathways": ["R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"], "type": "Domain"}, "IPR032106": {"description": "2-oxoglutarate dehydrogenase E1 component, N-terminal domain", "go_ids": [], "go_terms": [], "name": "2-oxogl_dehyd_N", "pathway_ids": ["R-SSC-9837999", "R-DDI-6783984", "R-HSA-9837999", "R-SPO-6783984", "R-MMU-9853506", "R-BTA-9853506", "PWY-5084", "R-DDI-9837999", "R-MMU-9837999", "R-MMU-6783984", "R-CEL-9837999", "R-SCE-9853506", "R-CEL-6783984", "R-SPO-9853506", "R-HSA-9853506", "R-CEL-9853506", "R-SCE-6783984", "R-RNO-9837999", "R-RNO-9853506", "R-RNO-6783984", "R-DDI-9853506", "R-SSC-9853506", "R-SSC-6783984", "R-BTA-6783984", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-HSA-6783984"], "pathways": ["R-SSC-9837999:r:Mitochondrial protein degradation", "R-DDI-6783984:r:Glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-BTA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "PWY-5084:t:2-oxoglutarate decarboxylation to succinyl-CoA", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6783984:r:Glycine degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-CEL-6783984:r:Glycine degradation", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-CEL-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SCE-6783984:r:Glycine degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-RNO-6783984:r:Glycine degradation", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-6783984:r:Glycine degradation", "R-BTA-6783984:r:Glycine degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-6783984:r:Glycine degradation"], "type": "Domain"}, "IPR032108": {"description": "CLIP1, zinc knuckle", "go_ids": [], "go_terms": [], "name": "CLIP1_ZNF", "pathway_ids": ["R-HSA-9842640", "R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-MMU-5626467", "R-HSA-5626467", "R-RNO-2500257", "R-MMU-2467813", "R-RNO-5626467", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-RNO-5663220", "R-HSA-68877", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Domain"}, "IPR032109": {"description": "Bacterial Ig-like domain (group 3)", "go_ids": [], "go_terms": [], "name": "Big_3_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032111": {"description": "Putative Holin, phages", "go_ids": [], "go_terms": [], "name": "Put_Holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032117": {"description": "Caskin, C-terminal", "go_ids": [], "go_terms": [], "name": "Caskin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032118": {"description": "Bacteriophage holin HP1 family", "go_ids": [], "go_terms": [], "name": "Phage_holin_HP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032121": {"description": "Mycobacterial phage holin", "go_ids": [], "go_terms": [], "name": "Myco_phage_holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032124": {"description": "Bacteriophage F116-like holin", "go_ids": [], "go_terms": [], "name": "Phage_F116_holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032126": {"description": "LydA-like holin", "go_ids": [], "go_terms": [], "name": "LydA_holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032127": {"description": "LydA-holin antagonist LydB", "go_ids": [], "go_terms": [], "name": "LydB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032128": {"description": "Pyocin R2, holin", "go_ids": [], "go_terms": [], "name": "Pyocin_R2_holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032129": {"description": "Protein of unknown function DUF5056", "go_ids": [], "go_terms": [], "name": "DUF5056", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032134": {"description": "Protein of unknown function DUF4816", "go_ids": [], "go_terms": [], "name": "DUF4816", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032135": {"description": "Helix-turn-helix domain (DUF4817)", "go_ids": [], "go_terms": [], "name": "DUF4817", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032136": {"description": "Neutrophil cytosol factor 1, PBR/AIR", "go_ids": [], "go_terms": [], "name": "NCF1_PBR/AIR", "pathway_ids": ["R-RNO-1236973", "R-MMU-1222556", "R-HSA-3299685", "R-RNO-9013149", "R-HSA-1236973", "R-MMU-4420097", "R-RNO-1222556", "R-MMU-9013404", "R-MMU-3299685", "R-MMU-1236973", "R-RNO-3299685", "R-RNO-5668599", "R-HSA-9013423", "R-HSA-4420097", "R-HSA-9013149", "R-HSA-9013404", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-1222556", "R-MMU-5668599", "R-RNO-9013404", "R-MMU-9013149", "R-HSA-5668599", "R-RNO-4420097"], "pathways": ["R-RNO-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR032140": {"description": "Intersectin-1, AP2 binding region", "go_ids": [], "go_terms": [], "name": "INTAP", "pathway_ids": ["R-HSA-193648", "R-MMU-8856828", "R-RNO-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-9013408", "R-HSA-416482", "R-RNO-9013148", "R-MMU-9013148", "R-HSA-3928662", "R-RNO-416482", "R-HSA-8856825", "R-MMU-9013406", "R-MMU-416482", "R-HSA-9013148", "R-MMU-3928662", "R-RNO-3928662", "R-MMU-193648", "R-RNO-9013408", "R-RNO-9013406", "R-HSA-9013408", "R-HSA-9013406", "R-RNO-8856828", "R-RNO-193648"], "pathways": ["R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-193648:r:NRAGE signals death through JNK", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-193648:r:NRAGE signals death through JNK"], "type": "Domain"}, "IPR032143": {"description": "BLOC-1-related complex subunit 7", "go_ids": [], "go_terms": [], "name": "BORCS7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032145": {"description": "Protein of unknown function DUF4818", "go_ids": [], "go_terms": [], "name": "DUF4818", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032147": {"description": "Protein capicua homolog-like domain", "go_ids": [], "go_terms": [], "name": "Cic_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032149": {"description": "Domain of unknown function DUF4988", "go_ids": [], "go_terms": [], "name": "DUF4988", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032150": {"description": "Protein of unknown function DUF4820", "go_ids": [], "go_terms": [], "name": "DUF4820", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032151": {"description": "Cilia- and flagella-associated protein 61, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CFAP61_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032152": {"description": "Domain of unknown function DUF4989", "go_ids": [], "go_terms": [], "name": "DUF4989", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032153": {"description": "BT_4170-like, C-terminal", "go_ids": [], "go_terms": [], "name": "BT_4170-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032154": {"description": "Coatomer subunit gamma, C-terminal", "go_ids": [], "go_terms": [], "name": "Coatomer_g_Cpla", "pathway_ids": ["R-SPO-6807878", "R-SCE-6807878", "R-RNO-6811434", "R-SCE-6811434", "R-RNO-6807878", "R-XTR-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-DDI-6811434", "R-CEL-6811434", "R-DME-6811434", "R-BTA-6807878", "R-HSA-6811434", "R-XTR-6811434", "R-DDI-6807878", "R-DRE-6811434", "R-SPO-6811434", "R-DRE-6807878", "R-DME-6807878", "R-BTA-6811434", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-XTR-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR032155": {"description": "Domain of unknown function DUF4992", "go_ids": [], "go_terms": [], "name": "DUF4992", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032157": {"description": "Proteasome assembly chaperone 4", "go_ids": ["GO:0043248"], "go_terms": ["GO:0043248:proteasome assembly:P"], "name": "PAC4", "pathway_ids": ["R-HSA-9907900", "R-SPO-9907900", "R-MMU-9907900", "R-DDI-9907900"], "pathways": ["R-HSA-9907900:r:Proteasome assembly", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-9907900:r:Proteasome assembly", "R-DDI-9907900:r:Proteasome assembly"], "type": "Family"}, "IPR032159": {"description": "Domain of unknown function DUF4995", "go_ids": [], "go_terms": [], "name": "DUF4995", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032160": {"description": "Domain of unknown function DUF4996", "go_ids": [], "go_terms": [], "name": "DUF4996", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032163": {"description": "Domain of unknown function DUF4999", "go_ids": [], "go_terms": [], "name": "DUF4999", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032164": {"description": "Domain of unknown function DUF5000", "go_ids": [], "go_terms": [], "name": "DUF5000", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032165": {"description": "Ig-like domain", "go_ids": [], "go_terms": [], "name": "DUF5001", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032167": {"description": "Domain of unknown function DUF5003", "go_ids": [], "go_terms": [], "name": "DUF5003", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032168": {"description": "Protein of unknown function DUF5004", "go_ids": [], "go_terms": [], "name": "DUF5004", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032169": {"description": "Protein of unknown function DUF5005", "go_ids": [], "go_terms": [], "name": "DUF5005", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032170": {"description": "Domain of unknown function DUF5006", "go_ids": [], "go_terms": [], "name": "DUF5006", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032171": {"description": "C-terminal of Roc, COR-A domain", "go_ids": [], "go_terms": [], "name": "COR-A", "pathway_ids": ["R-DDI-1483248", "R-DDI-1632852", "R-DDI-3295583", "R-DDI-1660516", "R-DDI-1660499", "R-DDI-5675221", "R-DDI-5675482", "R-DDI-5213460", "R-DDI-5674135", "R-MMU-2672351", "R-DDI-8876198", "R-DDI-5673000", "R-DDI-1660517", "R-MMU-8857538", "R-HSA-8857538"], "pathways": ["R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-DDI-1632852:r:Macroautophagy", "R-DDI-3295583:r:TRP channels", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-5673000:r:RAF activation", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Domain"}, "IPR032172": {"description": "Fragile X-related protein 1, C-terminal region 1", "go_ids": [], "go_terms": [], "name": "FXR1_C1", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR032173": {"description": "Protein of unknown function DUF5007", "go_ids": [], "go_terms": [], "name": "DUF5007", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032174": {"description": "RNA helicase aquarius, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Aquarius_N", "pathway_ids": ["R-HSA-72163", "R-MMU-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-SPO-6782210", "R-MMU-72163", "R-HSA-6782210", "R-MMU-6782210", "R-HSA-6782135", "R-SPO-6782135", "R-SPO-72163", "R-HSA-9918481", "R-HSA-6781823"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex"], "type": "Domain"}, "IPR032175": {"description": "Domain of unknown function DUF5008", "go_ids": [], "go_terms": [], "name": "DUF5008", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032176": {"description": "Domain of unknown function DUF5009", "go_ids": [], "go_terms": [], "name": "DUF5009", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032177": {"description": "Fragile X-related 1 protein, C-terminal region 3", "go_ids": [], "go_terms": [], "name": "FXR_C3", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR032178": {"description": "Domain of unknown function DUF5010", "go_ids": [], "go_terms": [], "name": "DUF5010", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032179": {"description": "Pesticidal crystal protein Cry22Aa, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Cry22Aa_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032180": {"description": "BT_2262-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BT_2262-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032181": {"description": "Domain of unknown function DUF5013", "go_ids": [], "go_terms": [], "name": "DUF5013", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032182": {"description": "Domain of unknown function DUF5014", "go_ids": [], "go_terms": [], "name": "DUF5014", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032183": {"description": "PKD-like family", "go_ids": [], "go_terms": [], "name": "PKD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032184": {"description": "Domain of unknown function DUF5016", "go_ids": [], "go_terms": [], "name": "DUF5016", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032185": {"description": "Domain of unknown function DUF5017", "go_ids": [], "go_terms": [], "name": "DUF5017", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032186": {"description": "Domain of unknown function DUF5018", "go_ids": [], "go_terms": [], "name": "DUF5018", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032187": {"description": "Outer membrane protein SusF/SusE-like, C-terminal", "go_ids": ["GO:2001070", "GO:0019867"], "go_terms": ["GO:2001070:starch binding:F", "GO:0019867:outer membrane:C"], "name": "SusF/SusE-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032189": {"description": "DNA mismatch repair protein Mlh1, C-terminal", "go_ids": [], "go_terms": [], "name": "Mlh1_C", "pathway_ids": ["R-RNO-5358565", "R-HSA-5545483", "R-SCE-5358565", "R-SPO-5358565", "R-HSA-912446", "R-HSA-5358606", "R-HSA-5358565", "R-HSA-6796648", "R-DDI-5358565", "R-MMU-5358565", "R-HSA-5632987"], "pathways": ["R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632987:r:Defective Mismatch Repair Associated With PMS2"], "type": "Domain"}, "IPR032190": {"description": "Niemann-Pick C1, N-terminal", "go_ids": [], "go_terms": [], "name": "NPC1_N", "pathway_ids": ["R-CEL-8963678", "R-HSA-8963678", "R-DME-8963678", "R-SCE-8963678", "R-MMU-8963678", "R-CEL-8964038", "R-MMU-8964038", "R-SCE-8964038", "R-RNO-8963678", "R-HSA-8964038"], "pathways": ["R-CEL-8963678:r:Intestinal lipid absorption", "R-HSA-8963678:r:Intestinal lipid absorption", "R-DME-8963678:r:Intestinal lipid absorption", "R-SCE-8963678:r:Intestinal lipid absorption", "R-MMU-8963678:r:Intestinal lipid absorption", "R-CEL-8964038:r:LDL clearance", "R-MMU-8964038:r:LDL clearance", "R-SCE-8964038:r:LDL clearance", "R-RNO-8963678:r:Intestinal lipid absorption", "R-HSA-8964038:r:LDL clearance"], "type": "Domain"}, "IPR032191": {"description": "CCR4-NOT transcription complex subunit 1, CAF1-binding domain", "go_ids": [], "go_terms": [], "name": "CNOT1_CAF1_bind", "pathway_ids": ["R-XTR-429947", "R-MMU-6804115", "R-HSA-6804115", "R-XTR-6804115", "R-DRE-6804115", "R-HSA-429947", "R-MMU-429947", "R-HSA-9820841"], "pathways": ["R-XTR-429947:r:Deadenylation of mRNA", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR032192": {"description": "GUN4, N-terminal ARM-like repeat domain", "go_ids": [], "go_terms": [], "name": "GUN4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032193": {"description": "CCR4-NOT transcription complex subunit 1, TTP binding domain", "go_ids": [], "go_terms": [], "name": "CNOT1_TTP_bind", "pathway_ids": ["R-XTR-429947", "R-MMU-6804115", "R-HSA-6804115", "R-XTR-6804115", "R-DRE-6804115", "R-HSA-429947", "R-MMU-429947", "R-HSA-9820841"], "pathways": ["R-XTR-429947:r:Deadenylation of mRNA", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR032194": {"description": "CCR4-NOT transcription complex subunit 1, HEAT repeat", "go_ids": [], "go_terms": [], "name": "CNOT1_HEAT", "pathway_ids": ["R-XTR-429947", "R-MMU-6804115", "R-HSA-6804115", "R-XTR-6804115", "R-DRE-6804115", "R-HSA-429947", "R-MMU-429947", "R-HSA-9820841"], "pathways": ["R-XTR-429947:r:Deadenylation of mRNA", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR032195": {"description": "CCR4-NOT transcription complex subunit 1, HEAT repeat 1", "go_ids": [], "go_terms": [], "name": "CNOT1_HEAT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032196": {"description": "Fragile X messenger ribonucleoprotein 1, C-terminal region 2", "go_ids": [], "go_terms": [], "name": "FMR1_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032197": {"description": "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal", "go_ids": [], "go_terms": [], "name": "Atg7_N", "pathway_ids": ["R-HSA-6798695", "R-GGA-983168", "R-SPO-6798695", "R-DDI-6798695", "R-DDI-1632852", "R-GGA-1632852", "R-HSA-6802952", "R-MMU-1632852", "R-HSA-9918485", "R-SCE-6798695", "R-HSA-983168", "R-GGA-6798695", "R-DDI-983168", "R-SCE-1632852", "R-RNO-1632852", "R-HSA-1632852", "R-MMU-983168", "R-MMU-6798695", "R-RNO-983168", "R-SPO-1632852", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-1632852:r:Macroautophagy", "R-GGA-1632852:r:Macroautophagy", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-1632852:r:Macroautophagy", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-6798695:r:Neutrophil degranulation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-1632852:r:Macroautophagy", "R-RNO-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-1632852:r:Macroautophagy", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR032198": {"description": "E2F transcription factor, CC-MB domain", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "E2F_CC-MB", "pathway_ids": ["R-MMU-8953750", "R-HSA-2559580", "R-HSA-69205", "R-DME-69231", "R-HSA-2559585", "R-RNO-2173796", "R-HSA-69231", "R-HSA-8953750", "R-HSA-139915", "R-HSA-1912408", "R-MMU-1538133", "R-RNO-68911", "R-HSA-69656", "R-HSA-1538133", "R-DME-8953750", "R-HSA-9616222", "R-BTA-8953750", "R-MMU-68911", "R-HSA-2173796", "R-RNO-1538133", "R-HSA-9661069", "R-HSA-113501", "R-HSA-1362300", "R-MMU-2173796", "R-MMU-69231", "R-DME-1538133", "R-RNO-69231", "R-HSA-1362277", "R-HSA-6804114", "R-HSA-111448", "R-DME-2173796", "R-HSA-68911", "R-DME-68911", "R-HSA-69202", "R-HSA-6804116"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-69205:r:G1/S-Specific Transcription", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-MMU-1538133:r:G0 and Early G1", "R-RNO-68911:r:G2 Phase", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-1538133:r:G0 and Early G1", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-68911:r:G2 Phase", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-1538133:r:G0 and Early G1", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-1538133:r:G0 and Early G1", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-68911:r:G2 Phase", "R-DME-68911:r:G2 Phase", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "type": "Domain"}, "IPR032199": {"description": "RecQ-mediated genome instability protein 1, C-terminal OB-fold domain", "go_ids": ["GO:0000166"], "go_terms": ["GO:0000166:nucleotide binding:F"], "name": "RMI1_C", "pathway_ids": ["R-DRE-5693607", "R-BTA-69473", "R-BTA-5685938", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-DRE-5693568", "R-HSA-9709570", "R-HSA-5693607", "R-BTA-6804756", "R-BTA-5693616", "R-BTA-5693579", "R-BTA-5693607", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-BTA-5693568", "R-HSA-69473", "R-MMU-5685942", "R-DRE-5685942", "R-HSA-9709603", "R-HSA-6804756", "R-DRE-69473", "R-HSA-9704331", "R-BTA-5685942", "R-DRE-5693616", "R-HSA-5693554", "R-HSA-5693579", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR032200": {"description": "Transcription factor COE, DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "COE_DBD", "pathway_ids": ["R-HSA-9844594", "R-HSA-9752946", "R-HSA-381340"], "pathways": ["R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR032201": {"description": "Transcription factor COE, helix-loop-helix domain", "go_ids": [], "go_terms": [], "name": "COE_HLH", "pathway_ids": ["R-HSA-9844594", "R-HSA-9752946", "R-HSA-381340"], "pathways": ["R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR032203": {"description": "Protein of unknown function (DUF5022)", "go_ids": [], "go_terms": [], "name": "DUF5022", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032205": {"description": "Protein of unknown function DUF5024", "go_ids": [], "go_terms": [], "name": "DUF5024", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032206": {"description": "Protein of unknown function DUF5025", "go_ids": [], "go_terms": [], "name": "DUF5025", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032207": {"description": "Protein of unknown function DUF5026", "go_ids": [], "go_terms": [], "name": "DUF5026", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032208": {"description": "Protein of unknown function DUF5027", "go_ids": [], "go_terms": [], "name": "DUF5027", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032209": {"description": "Protein of unknown function DUF5028", "go_ids": [], "go_terms": [], "name": "DUF5028", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032210": {"description": "Protein of unknown function DUF5029", "go_ids": [], "go_terms": [], "name": "DUF5029", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032211": {"description": "Protein of unknown function DUF5030", "go_ids": [], "go_terms": [], "name": "DUF5030", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032212": {"description": "Protein of unknown function DUF5031", "go_ids": [], "go_terms": [], "name": "DUF5031", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032213": {"description": "Protein of unknown function DUF5032", "go_ids": [], "go_terms": [], "name": "DUF5032", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032214": {"description": "Protein of unknown function DUF5033", "go_ids": [], "go_terms": [], "name": "DUF5033", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032215": {"description": "Protein of unknown function DUF5034", "go_ids": [], "go_terms": [], "name": "DUF5034", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032216": {"description": "Protein of unknown function DUF5035", "go_ids": [], "go_terms": [], "name": "DUF5035", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032217": {"description": "Protein of unknown function DUF5036", "go_ids": [], "go_terms": [], "name": "DUF5036", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032218": {"description": "Protein of unknown function DUF5037", "go_ids": [], "go_terms": [], "name": "DUF5037", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032219": {"description": "Protein of unknown function DUF5038", "go_ids": [], "go_terms": [], "name": "DUF5038", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032220": {"description": "Protein of unknown function DUF5039", "go_ids": [], "go_terms": [], "name": "DUF5039", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032221": {"description": "Protein of unknown function DUF5040", "go_ids": [], "go_terms": [], "name": "DUF5040", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032222": {"description": "Protein of unknown function DUF5041", "go_ids": [], "go_terms": [], "name": "DUF5041", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032226": {"description": "TNRC6, PABC binding domain", "go_ids": [], "go_terms": [], "name": "TNRC6_PABC-bd", "pathway_ids": ["R-HSA-8853884", "R-HSA-9022692", "R-MMU-426496", "R-HSA-2559580", "R-HSA-8936459", "R-HSA-5578749", "R-HSA-2559585", "R-HSA-8948700", "R-HSA-5628897", "R-HSA-9764562", "R-HSA-1912408", "R-HSA-9759811", "R-HSA-4086398", "R-HSA-9029569", "R-HSA-9824594", "R-HSA-9018519", "R-MMU-5578749", "R-HSA-9839394", "R-HSA-8943723", "R-HSA-8934593", "R-HSA-9725371", "R-HSA-9768778", "R-HSA-5687128", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-426496"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs"], "type": "Domain"}, "IPR032232": {"description": "Caskin-1, CASK-interaction domain", "go_ids": [], "go_terms": [], "name": "Caskin1-CID", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032237": {"description": "CRISPR-associated endonuclease Cas9, PAM-interacting domain", "go_ids": [], "go_terms": [], "name": "Cas9_PI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032238": {"description": "Putative ATP-synthase-associated protein", "go_ids": [], "go_terms": [], "name": "ATP-synth_Z", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032239": {"description": "CRISPR-associated endonuclease Cas9, bridge helix", "go_ids": [], "go_terms": [], "name": "Cas9-BH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032240": {"description": "CRISPR-associated endonuclease Cas9, REC lobe", "go_ids": [], "go_terms": [], "name": "Cas9_REC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032241": {"description": "Protein of unknown function DUF5042", "go_ids": [], "go_terms": [], "name": "DUF5042", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032242": {"description": "Protein of unknown function DUF5043", "go_ids": [], "go_terms": [], "name": "DUF5043", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032243": {"description": "Protein of unknown function DUF5044", "go_ids": [], "go_terms": [], "name": "DUF5044", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032244": {"description": "LapD/MoxY, periplasmic domain", "go_ids": [], "go_terms": [], "name": "LapD_MoxY_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032245": {"description": "RecQ-mediated genome instability protein 2", "go_ids": [], "go_terms": [], "name": "RMI2", "pathway_ids": ["R-GGA-5685938", "R-HSA-5685942", "R-GGA-5685942", "R-HSA-5693616", "R-HSA-69473", "R-GGA-5693568", "R-HSA-9704646", "R-GGA-5693616", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-GGA-5693607", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-GGA-5693579", "R-MMU-5693607", "R-HSA-9701192"], "pathways": ["R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-GGA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-GGA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-GGA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-GGA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Family"}, "IPR032247": {"description": "Domain of unknown function DUF4822", "go_ids": [], "go_terms": [], "name": "DUF4822", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032248": {"description": "Protein of unknown function DUF4823", "go_ids": [], "go_terms": [], "name": "DUF4823", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032249": {"description": "Protein of unknown function DUF4824", "go_ids": [], "go_terms": [], "name": "DUF4824", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032250": {"description": "Domain of unknown function DUF4825", "go_ids": [], "go_terms": [], "name": "DUF4825", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032251": {"description": "Protein of unknown function DUF4826", "go_ids": [], "go_terms": [], "name": "DUF4826", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032252": {"description": "Outer membrane protein assembly factor BamK", "go_ids": [], "go_terms": [], "name": "BamK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032253": {"description": "Exocrine gland-secreted peptide Esp1/Esp22", "go_ids": ["GO:0005186", "GO:0005576"], "go_terms": ["GO:0005186:pheromone activity:F", "GO:0005576:extracellular region:C"], "name": "Esp1/Esp22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032254": {"description": "Protein of unknown function DUF4828", "go_ids": [], "go_terms": [], "name": "DUF4828", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032255": {"description": "Helical bimodular sensor domain", "go_ids": [], "go_terms": [], "name": "HBM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032256": {"description": "Domain of unknown function DUF4829", "go_ids": [], "go_terms": [], "name": "DUF4829", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032257": {"description": "Domain of unknown function DUF4830", "go_ids": [], "go_terms": [], "name": "DUF4830", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032259": {"description": "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type", "go_ids": ["GO:0003860"], "go_terms": ["GO:0003860:3-hydroxyisobutyryl-CoA hydrolase activity:F"], "name": "HIBYL-CoA-H", "pathway_ids": ["PWY-6373", "PWY-3941", "PWY-7574", "R-DDI-70895", "R-DRE-70895", "R-HSA-70895", "R-SPO-70895", "R-HSA-9916722", "R-MMU-70895", "R-SCE-70895", "R-RNO-70895"], "pathways": ["PWY-6373:t:acrylate degradation I", "PWY-3941:t:beta-alanine biosynthesis II", "PWY-7574:t:propanoyl-CoA degradation II", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-DRE-70895:r:Branched-chain amino acid catabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-SPO-70895:r:Branched-chain amino acid catabolism", "R-HSA-9916722:r:3-hydroxyisobutyryl-CoA hydrolase deficiency", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-SCE-70895:r:Branched-chain amino acid catabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Family"}, "IPR032260": {"description": "Domain of unknown function DUF5060", "go_ids": [], "go_terms": [], "name": "DUF5060", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032262": {"description": "Zinc-regulated secreted antivirulence protein, C-terminal", "go_ids": [], "go_terms": [], "name": "ZirS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032263": {"description": "ATP-citrate synthase, citrate-binding domain", "go_ids": [], "go_terms": [], "name": "Citrate-bd", "pathway_ids": ["PWY-5172", "R-HSA-163765", "R-HSA-6798695", "R-BTA-75105", "R-HSA-75105", "R-CEL-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-RNO-75105", "R-MMU-75105", "R-RNO-6798695", "R-CEL-75105"], "pathways": ["PWY-5172:t:acetyl-CoA biosynthesis from citrate", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR032264": {"description": "Menaquinone biosynthesis protein MenD, middle domain", "go_ids": [], "go_terms": [], "name": "MenD_middle", "pathway_ids": ["PWY-5837"], "pathways": ["PWY-5837:t:2-carboxy-1,4-naphthoquinol biosynthesis"], "type": "Domain"}, "IPR032265": {"description": "Protein of unknown function DUF4831", "go_ids": [], "go_terms": [], "name": "DUF4831", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032266": {"description": "Putative cytidyltransferase-related, C-terminal region", "go_ids": [], "go_terms": [], "name": "HIGH_NTase1_ass", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032267": {"description": "Domain of unknown function DUF4832", "go_ids": [], "go_terms": [], "name": "DUF4832", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032268": {"description": "Capsid polyprotein VP90, C-terminal", "go_ids": [], "go_terms": [], "name": "VP90_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032269": {"description": "Domain of unknown function DUF4833", "go_ids": [], "go_terms": [], "name": "DUF4833", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032270": {"description": "AMPK, C-terminal adenylate sensor domain", "go_ids": [], "go_terms": [], "name": "AMPK_C", "pathway_ids": ["R-HSA-9619483", "R-MMU-380972", "R-SSC-5628897", "R-MMU-1632852", "R-CEL-1632852", "R-MMU-6804756", "R-RNO-163680", "R-DDI-200425", "R-HSA-5628897", "R-RNO-1632852", "R-MMU-9759194", "R-SPO-200425", "R-RNO-200425", "R-HSA-9759194", "R-MMU-5628897", "R-SPO-163680", "R-RNO-6804756", "R-SSC-9931269", "R-HSA-9613354", "R-SCE-200425", "R-SCE-163680", "R-HSA-380972", "R-SSC-6804756", "R-SSC-163680", "R-DDI-163680", "R-MMU-163680", "R-HSA-9931269", "R-DDI-5628897", "R-SSC-380972", "R-DDI-1632852", "R-MMU-200425", "R-SPO-5628897", "R-SPO-380972", "R-CEL-5628897", "R-RNO-5628897", "R-RNO-9931269", "R-DDI-380972", "R-CEL-380972", "R-RNO-9759194", "R-HSA-2151209", "R-CEL-9759194", "R-SSC-9759194", "R-SCE-1632852", "R-HSA-6804756", "R-SCE-380972", "R-HSA-200425", "R-RNO-380972", "R-HSA-1445148", "R-SSC-200425", "R-HSA-1632852", "R-SSC-1632852", "R-MMU-9931269", "R-SPO-1632852", "R-HSA-163680"], "pathways": ["R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-DDI-200425:r:Carnitine shuttle", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-1632852:r:Macroautophagy", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-SPO-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9613354:r:Lipophagy", "R-SCE-200425:r:Carnitine shuttle", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SSC-6804756:r:Regulation of 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and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-XTR-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72695:r:Formation of the ternary complex, and 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"R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-DME-72649:r:Translation initiation complex formation", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-72649:r:Translation initiation complex formation", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-72649:r:Translation initiation complex formation", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR032282": {"description": "Hydroxyacylglutathione hydrolase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HAGH_C", "pathway_ids": ["PWY-5386", "R-MMU-70268", "R-HSA-9864848", "R-RNO-70268", "R-DDI-70268", "R-DRE-70268", "R-SPO-70268", "R-HSA-70268", "R-BTA-70268", "R-SCE-70268"], "pathways": ["PWY-5386:t:methylglyoxal degradation I", "R-MMU-70268:r:Pyruvate metabolism", "R-HSA-9864848:r:Complex IV assembly", "R-RNO-70268:r:Pyruvate metabolism", "R-DDI-70268:r:Pyruvate metabolism", "R-DRE-70268:r:Pyruvate metabolism", "R-SPO-70268:r:Pyruvate metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Domain"}, "IPR032283": {"description": "Domain of unknown function DUF4984", "go_ids": [], "go_terms": [], "name": "DUF4984", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032284": {"description": "ATP-dependent DNA helicase RecQ, zinc-binding domain", "go_ids": [], "go_terms": [], "name": "RecQ_Zn-bd", "pathway_ids": ["R-HSA-3108214", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-174414", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-HSA-174437", "R-HSA-9709570", "R-MMU-174414", "R-HSA-5693607", "R-HSA-912446", "R-MMU-174437", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-DME-3108214", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-69473", "R-MMU-5685942", "R-HSA-9709603", "R-HSA-6804756", "R-HSA-9704331", "R-MMU-3108214", "R-HSA-5693554", "R-HSA-5693579"], "pathways": ["R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing 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"R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange"], "type": "Domain"}, "IPR032285": {"description": "Calcineurin-like phosphoesterase, N-terminal", "go_ids": [], "go_terms": [], "name": "Metallophos_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032286": {"description": "Protein of unknown function DUF4837", "go_ids": [], "go_terms": [], "name": "DUF4837", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032287": {"description": "Protein of unknown function DUF4838", "go_ids": [], "go_terms": [], "name": "DUF4838", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032288": {"description": "Calcineurin-like phosphoesterase, C-terminal", "go_ids": [], "go_terms": [], "name": "Metallophos_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032290": {"description": "Protein of unknown function DUF4839", "go_ids": [], "go_terms": [], "name": "DUF4839", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032291": {"description": "Extracellular endo-alpha-(1->5)-L-arabinanase, C-terminal", "go_ids": [], "go_terms": [], "name": "Abn2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032292": {"description": "Cytoplasmic polyadenylation element-binding protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "CEBP1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032293": {"description": "Protein of unknown function DUF4840", "go_ids": [], "go_terms": [], "name": "DUF4840", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032294": {"description": "Domain of unknown function DUF4841", "go_ids": [], "go_terms": [], "name": "DUF4841", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032295": {"description": "Domain of unknown function DUF4842", "go_ids": [], "go_terms": [], "name": "DUF4842", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032296": {"description": "Cytoplasmic polyadenylation element-binding protein, ZZ domain", "go_ids": [], "go_terms": [], "name": "CEBP_ZZ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032297": {"description": "Torus domain", "go_ids": [], "go_terms": [], "name": "Torus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032298": {"description": "EutK-Ctail domain", "go_ids": [], "go_terms": [], "name": "EutK_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032299": {"description": "Protein of unknown function DUF4843", "go_ids": [], "go_terms": [], "name": "DUF4843", "pathway_ids": [], 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"Domain"}, "IPR032309": {"description": "Domain of unknown function DUF4983", "go_ids": [], "go_terms": [], "name": "DUF4983", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032310": {"description": "Ninja/AFP-like, putative nuclear localisation signal", "go_ids": [], "go_terms": [], "name": "NLS_NINJA_AFP-like", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR032311": {"description": "Domain of unknown function DUF4982", "go_ids": [], "go_terms": [], "name": "DUF4982", "pathway_ids": ["PWY-7247", "PWY-7445"], "pathways": ["PWY-7247:t:beta-D-glucuronide and D-glucuronate degradation", "PWY-7445:t:luteolin triglucuronide degradation"], "type": "Domain"}, "IPR032312": {"description": "Beta-galactosidase, domain 4", "go_ids": [], "go_terms": [], "name": "LacZ_4", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR032313": {"description": "Domain of unknown function DUF4980", "go_ids": [], "go_terms": [], "name": "DUF4980", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032314": {"description": "Protein of unknown function DUF4845", "go_ids": [], "go_terms": [], "name": "DUF4845", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032315": {"description": "Protein of unknown function DUF4846", "go_ids": [], "go_terms": [], "name": "DUF4846", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032316": {"description": "Protein of unknown function DUF4847", "go_ids": [], "go_terms": [], "name": "DUF4847", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032318": {"description": "Protein of unknown function DUF4848", "go_ids": [], "go_terms": [], "name": "DUF4848", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032319": {"description": "Clp1, P-loop domain", "go_ids": [], "go_terms": [], "name": "CLP1_P", "pathway_ids": ["R-DME-77595", "R-MMU-9770562", "R-GGA-73856", "R-XTR-9770562", "R-DDI-6791226", "R-MMU-77595", "R-DME-6791226", "R-HSA-73856", "R-RNO-77595", "R-DDI-9770562", "R-CEL-73856", "R-HSA-72187", "R-CEL-77595", "R-RNO-73856", "R-SCE-9770562", "R-DME-9770562", "R-HSA-77595", "R-DRE-73856", "R-DRE-9770562", "R-SCE-6791226", "R-CEL-9770562", "R-GGA-9770562", "R-DME-73856", "R-CEL-6791226", "R-HSA-9918481", "R-BTA-77595", "R-MMU-6791226", "R-HSA-9770562", "R-DRE-77595", "R-HSA-6784531", "R-BTA-73856", "R-MMU-73856", "R-SPO-9770562", "R-MMU-72187", "R-HSA-6791226", "R-RNO-9770562", "R-DRE-6791226", "R-BTA-9770562", "R-SPO-6791226"], "pathways": ["R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-9770562:r:mRNA Polyadenylation", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-SCE-9770562:r:mRNA Polyadenylation", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-9770562:r:mRNA Polyadenylation", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9770562:r:mRNA Polyadenylation", "R-GGA-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-9770562:r:mRNA Polyadenylation", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9770562:r:mRNA Polyadenylation", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR032320": {"description": "Glycoside hydrolase family 18, BT1044-like", "go_ids": [], "go_terms": [], "name": "GH18_BT1044-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032321": {"description": "Centrosomal protein of 290kDa, coiled-coil region", "go_ids": [], "go_terms": [], "name": "Cep209_CC5", "pathway_ids": ["R-HSA-6798695", "R-HSA-380320", "R-MMU-380259", "R-DRE-6798695", "R-MMU-2565942", "R-MMU-8854518", "R-MMU-6798695", "R-HSA-380284", "R-DRE-380320", "R-MMU-380270", "R-MMU-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR032322": {"description": "Protein of unknown function DUF4850", "go_ids": [], "go_terms": [], "name": "DUF4850", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032323": {"description": "Protein of unknown function DUF4851", "go_ids": [], "go_terms": [], "name": "DUF4851", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032324": {"description": "Clp1, N-terminal", "go_ids": [], "go_terms": [], "name": "Clp1_N", "pathway_ids": ["R-HSA-9770562", "R-DRE-77595", "R-DME-77595", "R-GGA-73856", "R-XTR-9770562", "R-MMU-9770562", "R-HSA-6784531", "R-MMU-77595", "R-BTA-73856", "R-RNO-77595", "R-HSA-73856", "R-DDI-9770562", "R-CEL-73856", "R-MMU-73856", "R-HSA-72187", "R-CEL-77595", "R-RNO-73856", "R-SCE-9770562", "R-SPO-9770562", "R-DME-9770562", "R-HSA-77595", "R-DRE-73856", "R-MMU-72187", "R-DRE-9770562", "R-CEL-9770562", "R-RNO-9770562", "R-BTA-9770562", "R-GGA-9770562", "R-DME-73856", "R-HSA-9918481", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-SCE-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-DRE-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-GGA-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR032325": {"description": "Protein of unknown function DUF4852", "go_ids": [], "go_terms": [], "name": "DUF4852", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032326": {"description": "Protein of unknown function DUF4853", "go_ids": [], "go_terms": [], "name": "DUF4853", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032327": {"description": "Protein of unknown function DUF4854", "go_ids": [], "go_terms": [], "name": "DUF4854", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032329": {"description": "Protein of unknown function DUF4855", "go_ids": [], "go_terms": [], "name": "DUF4855", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032330": {"description": "Elongation factor G-binding protein, C-terminal treble-clef zinc-finger", "go_ids": [], "go_terms": [], "name": "EF-G-binding_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032331": {"description": "Protein of unknown function DUF4856", "go_ids": [], "go_terms": [], "name": "DUF4856", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032332": {"description": "Gram-positive pilin backbone subunit 3, Cna-B-like domain", "go_ids": [], "go_terms": [], "name": "GramPos_pilinD3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032333": {"description": "Protein of unknown function DUF4857", "go_ids": [], "go_terms": [], "name": "DUF4857", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032334": {"description": "Gram-positive pilin backbone subunit 2, Cna-B-like domain", "go_ids": [], "go_terms": [], "name": "GramPos_pilinBB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032335": {"description": "Sam68, tyrosine-rich domain", "go_ids": [], "go_terms": [], "name": "Sam68-YY", "pathway_ids": ["R-XTR-8849468", "R-DRE-8849468", "R-MMU-8849468", "R-RNO-8849468", "R-HSA-8849468"], "pathways": ["R-XTR-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-DRE-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing"], "type": "Domain"}, "IPR032336": {"description": "Pathogenicity island component CagD", "go_ids": [], "go_terms": [], "name": "CagD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032337": {"description": "RPRD1A/B, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RPRD1A/B_C", "pathway_ids": ["R-CEL-6807505", "R-HSA-6807505", "R-BTA-6807505", "R-MMU-6807505"], "pathways": ["R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR032338": {"description": "Protein of unknown function DUF4858", "go_ids": [], "go_terms": [], "name": "DUF4858", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032339": {"description": "Domain of unknown function DUF4859", "go_ids": [], "go_terms": [], "name": "DUF4859", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032340": {"description": "Protein of unknown function DUF4860", "go_ids": [], "go_terms": [], "name": "DUF4860", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032341": {"description": "MITD1, C-terminal phospholipase D-like domain", "go_ids": [], "go_terms": [], "name": "MITD1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032342": {"description": "Protein of unknown function DUF4861", "go_ids": [], "go_terms": [], "name": "DUF4861", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032343": {"description": "Methyl-CpG-binding domain protein 2/3, p55-binding region", "go_ids": [], "go_terms": [], "name": "MBD2/MBD3_p55-bd", "pathway_ids": ["R-HSA-6804758", "R-HSA-73728", "R-MMU-73762", "R-HSA-9844594", "R-HSA-9845323", "R-HSA-8943724", "R-MMU-6804758", "R-HSA-427413", "R-MMU-3214815", "R-HSA-427389", "R-HSA-9843940", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-MMU-8943724"], "pathways": ["R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-73728:r:RNA Polymerase I Promoter Opening", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-8943724:r:Regulation of PTEN gene transcription"], "type": "Domain"}, "IPR032344": {"description": "Protein of unknown function DUF4862", "go_ids": [], "go_terms": [], "name": "DUF4862", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032345": {"description": "4-hydroxylaminobenzoate lyase", "go_ids": [], "go_terms": [], "name": "PnbB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032346": {"description": "Transcriptional repressor p66, coiled-coil MBD2-interaction domain", "go_ids": [], "go_terms": [], "name": "P66_CC", "pathway_ids": ["R-MMU-73762", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-MMU-8943724", "R-HSA-6804758", "R-HSA-9844594", "R-HSA-9845323", "R-HSA-8943724", "R-MMU-6804758", "R-HSA-9843940", "R-HSA-427389"], "pathways": ["R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"], "type": "Domain"}, "IPR032347": {"description": "Protein of unknown function DUF4864", "go_ids": [], "go_terms": [], "name": "DUF4864", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032348": {"description": "E3 ubiquitin-protein ligase HECW1/2, N-terminal", "go_ids": [], "go_terms": [], "name": "HECW_N", "pathway_ids": ["PWY-7511", "R-HSA-4641258", "R-HSA-983168", "R-MMU-4641258", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-4641258:r:Degradation of DVL", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR032349": {"description": "Protein of unknown function DUF4865", "go_ids": [], "go_terms": [], "name": "DUF4865", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032350": {"description": "Nbr1, FW domain", "go_ids": [], "go_terms": [], "name": "Nbr1_FW", "pathway_ids": ["R-SPO-9664873", "R-RNO-9664873", "R-HSA-9664873", "R-MMU-9664873"], "pathways": ["R-SPO-9664873:r:Pexophagy", "R-RNO-9664873:r:Pexophagy", "R-HSA-9664873:r:Pexophagy", "R-MMU-9664873:r:Pexophagy"], "type": "Domain"}, "IPR032351": {"description": "Putative mobile pathogenicity island", "go_ids": [], "go_terms": [], "name": "SAPI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032352": {"description": "Arf GTPase-activating protein GIT1/2, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "GIT1/2_CC", "pathway_ids": ["R-HSA-9013409", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-9013423", "R-MMU-9013420", "R-RNO-9013424", "R-HSA-9013148", "R-HSA-9619229", "R-RNO-9013404", "R-RNO-9013406", "R-MMU-3928664", "R-HSA-9013420", "R-HSA-3928664", "R-MMU-9013424", "R-RNO-9013420", "R-RNO-3928664", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-9013423", "R-HSA-9013149", "R-MMU-9013406", "R-HSA-9013406", "R-MMU-9013149"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-3928664:r:Ephrin signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR032353": {"description": "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain", "go_ids": [], "go_terms": [], "name": "AZUL", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR032354": {"description": "FOXP, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "FOXP-CC", "pathway_ids": ["R-HSA-452723", "R-MMU-8877330", "R-HSA-8877330", "R-HSA-8939256", "R-HSA-9764790"], "pathways": ["R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-MMU-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription"], "type": "Domain"}, "IPR032355": {"description": "SATB, CUT1-like DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "CUTL", "pathway_ids": ["R-MMU-4551638", "R-MMU-111465", "R-HSA-4551638", "R-HSA-8940973", "R-HSA-111465"], "pathways": ["R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Domain"}, "IPR032356": {"description": "IL17RA/B, N-terminal domain", "go_ids": [], "go_terms": [], "name": "IL17R_A/B_N", "pathway_ids": ["R-HSA-9705671", "R-HSA-448424", "R-CEL-5674135"], "pathways": ["R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-448424:r:Interleukin-17 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation"], "type": "Domain"}, "IPR032357": {"description": "Protein of unknown function DUF4866", "go_ids": [], "go_terms": [], "name": "DUF4866", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032358": {"description": "Protein of unknown function DUF4867", "go_ids": [], "go_terms": [], "name": "DUF4867", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032359": {"description": "Kiwa protein KwaB-like", "go_ids": [], "go_terms": [], "name": "KwaB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032360": {"description": "Protein of unknown function DUF4869", "go_ids": [], "go_terms": [], "name": "DUF4869", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032361": {"description": "von Willebrand factor, VWA N-terminal domain", "go_ids": [], "go_terms": [], "name": "VWA_N2", "pathway_ids": ["R-MMU-354192", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-216083", "R-MMU-5674135", "R-HSA-6802952", "R-HSA-9845620", "R-HSA-9656223", "R-MMU-76009", "R-HSA-140837", "R-HSA-430116", "R-HSA-9672393", "R-HSA-9845619", "R-MMU-430116", "R-HSA-354194", "R-MMU-140837", "R-MMU-354194", "R-HSA-9845622", "R-HSA-9845621", "R-MMU-372708", "R-HSA-114608", "R-HSA-76009", "R-HSA-75892", "R-MMU-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-9846298", "R-HSA-9672391", "R-MMU-216083", "R-HSA-372708", "R-HSA-6802955", "R-HSA-354192"], "pathways": ["R-MMU-354192:r:Integrin signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-354192:r:Integrin signaling"], "type": "Domain"}, "IPR032362": {"description": "Ferlin, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ferlin_C", "pathway_ids": ["R-HSA-9662360", "R-HSA-9609523", "R-HSA-445355"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-445355:r:Smooth Muscle Contraction"], "type": "Domain"}, "IPR032364": {"description": "Gram-positive pilin subunit D1, N-terminal", "go_ids": [], "go_terms": [], "name": "GramPos_pilinD1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032365": {"description": "BCL-6 corepressor, PCGF1 binding domain", "go_ids": [], "go_terms": [], "name": "PUFD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032366": {"description": "Protein of unknown function DUF4871", "go_ids": [], "go_terms": [], "name": "DUF4871", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032367": {"description": "Protein quaking, putative nuclear localisation signal", "go_ids": [], "go_terms": [], "name": "Quaking_NLS", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR032368": {"description": "RPN13, DEUBAD domain", "go_ids": [], "go_terms": [], "name": "RPN13_DEUBAD", "pathway_ids": ["R-HSA-174178", "R-DRE-4641258", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-HSA-8951664", "R-BTA-9755511", "R-HSA-9010553", "R-CEL-8941858", "R-HSA-75815", "R-DRE-2467813", "R-MMU-8948751", "R-DME-8948751", "R-DRE-8941858", "R-SPO-5689880", "R-MMU-5689880", "R-CEL-1234176", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-DME-5676590", "R-RNO-8854050", "R-HSA-450408", "R-DRE-69017", "R-RNO-450408", "R-HSA-211733", "R-DME-4641257", "R-HSA-5607761", "R-DDI-174084", "R-DRE-8948751", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DRE-9766229", "R-DDI-4641258", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-CEL-8948751", "R-DRE-5610785", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-DDI-187577", "R-RNO-69481", "R-RNO-9932298", "R-DDI-382556", "R-BTA-1236978", "R-DME-202424", "R-DME-187577", "R-RNO-1234176", "R-DRE-195253", "R-RNO-5632684", "R-MMU-187577", "R-DRE-5610780", "R-RNO-174178", "R-DRE-4641257", "R-BTA-4608870", "R-BTA-5676590", "R-HSA-9824272", "R-MMU-174178", "R-MMU-349425", "R-DRE-983168", "R-BTA-2871837", "R-CEL-8854050", "R-HSA-9907900", "R-BTA-174154", "R-DME-350562", "R-DME-174084", "R-DDI-69601", "R-DME-9929491", "R-HSA-9762114", "R-DDI-5689880", "R-HSA-195253", "R-DRE-174178", "R-DRE-5358346", "R-BTA-187577", "R-CEL-9755511", "R-RNO-9755511", "R-DME-8939236", "R-DME-174184", "R-RNO-174113", "R-BTA-9929356", "R-MMU-5676590", "R-MMU-174184", "R-RNO-187577", "R-RNO-68867", "R-RNO-350562", "R-DME-9932298", "R-RNO-9762114", "R-BTA-9954709", "R-DME-9020702", "R-RNO-69017", "R-CEL-9762114", "R-DME-5689880", "R-HSA-5358346", "R-CEL-8951664", "R-SPO-350562", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-BTA-5610785", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-DDI-1236978", "R-DDI-8951664", "R-MMU-8951664", "R-DME-8939902", "R-CEL-5689603", "R-CEL-382556", "R-RNO-174154", "R-MMU-9929356", "R-DME-4608870", "R-RNO-9929356", "R-HSA-69481", "R-DME-9762114", "R-BTA-174084", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DRE-9907900", "R-HSA-4641258", "R-RNO-8939236", "R-SPO-5689603", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-RNO-174184", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", "R-RNO-2467813", "R-DME-5607764", "R-DME-2871837", "R-DME-8941858", "R-DRE-382556", "R-MMU-5610780", "R-DME-9954709", "R-BTA-382556", "R-DRE-9762114", "R-CEL-8939902", "R-MMU-9755511", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-HSA-5362768", "R-DME-5689603", "R-DDI-9954709", "R-MMU-5658442", "R-RNO-8852276", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-DRE-68949", "R-BTA-8948751", "R-RNO-9907900", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-RNO-5607764", "R-RNO-8941858", "R-HSA-69017", "R-RNO-1169091", "R-BTA-9020702", "R-RNO-9766229", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-DRE-68867", "R-HSA-202424", "R-DDI-174154", "R-CEL-4641257", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-DRE-1169091", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-BTA-1234176", "R-MMU-174154", "R-MMU-69017", "R-CEL-195253", "R-DME-5658442", "R-MMU-9020702", "R-RNO-382556", "R-RNO-5687128", "R-DRE-8939236", "R-MMU-69481", "R-BTA-350562", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-DRE-187577", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-BTA-68867", "R-DRE-5668541", "R-DRE-174184", "R-HSA-1234176", "R-RNO-4641258", "R-HSA-9931269", "R-MMU-68867", "R-HSA-9929491", "R-DRE-69601", "R-RNO-5689880", "R-DRE-5689603", "R-DRE-9755511", "R-DME-75815", "R-DRE-350562", "R-RNO-8951664", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-MMU-5687128", "R-DRE-4608870", "R-RNO-5358346", "R-DME-5358346", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-DRE-349425", "R-BTA-195253", "R-DRE-8939902", "R-MMU-8852276", "R-BTA-68949", "R-MMU-68949", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-DME-9907900", "R-RNO-4641257", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-DRE-75815", "R-BTA-174184", "R-RNO-349425", "R-MMU-9762114", "R-MMU-195253", "R-MMU-202424", "R-BTA-8939236", "R-HSA-5610780", "R-MMU-382556", "R-BTA-5632684", "R-DRE-174154", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-RNO-75815", "R-MMU-1169091", "R-MMU-5607761", "R-DME-8854050", "R-CEL-5689880", "R-HSA-8939902", "R-DRE-9932298", "R-MMU-8939902", "R-DME-174178", "R-RNO-195253", "R-HSA-8939236", "R-DRE-8854050", "R-BTA-983168", "R-DDI-8854050", "R-MMU-5607764", "R-DRE-5632684", "R-DME-8951664", "R-DRE-8951664", "R-BTA-5668541", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-DRE-1236978", "R-DRE-9954709", "R-DDI-5632684", "R-BTA-9929491", "R-HSA-4641257", "R-RNO-202424", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9929491", "R-RNO-5607761", "R-HSA-68867", "R-DME-174154", "R-MMU-9907900", "R-CEL-4641258", "R-BTA-450408", "R-DDI-5658442", "R-HSA-8941858", "R-HSA-9755511", "R-DRE-1234176", "R-RNO-9931269", "R-CEL-9929491", "R-DME-9755511", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-DRE-5658442", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-RNO-174084", "R-HSA-5689603", "R-RNO-983168", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DME-1169091", "R-DDI-9755511", "R-DME-382556", "R-BTA-8941858", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-HSA-174184", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-DRE-9929491", "R-BTA-2467813", "R-MMU-5610785", "R-DRE-8852276", "R-DRE-69481", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-DRE-5687128", "R-DRE-5689880", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DRE-174084", "R-DRE-450408", "R-DDI-983168", "R-HSA-5668541", "R-HSA-9929356", "R-CEL-69601", "R-CEL-68949", "R-HSA-5687128", "R-DME-5632684", "R-RNO-5658442", "R-MMU-983168", "R-RNO-5610785", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-4641258:r:Degradation of DVL", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-DRE-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-69481:r:G2/M Checkpoints", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-5632684:r:Hedgehog 'on' state", 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"R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DRE-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DRE-69481:r:G2/M Checkpoints", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-DRE-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DRE-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-5632684:r:Hedgehog 'on' state", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR032369": {"description": "Domain of unknown function DUF4872", "go_ids": [], "go_terms": [], "name": "DUF4872", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032370": {"description": "Flagellar assembly protein T, N-terminal", "go_ids": [], "go_terms": [], "name": "FlgT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032371": {"description": "Domain of unknown function DUF4873", "go_ids": [], "go_terms": [], "name": "DUF4873", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032372": {"description": "Proteasome activator Blm10, N-terminal", "go_ids": [], "go_terms": [], "name": "Blm10_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032373": {"description": "Centromere kinetochore component CENP-T, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CENP-T_N", "pathway_ids": ["R-MMU-2500257", "R-HSA-606279", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-RNO-606279", "R-MMU-606279", "R-HSA-141444", "R-MMU-68877", "R-HSA-9648025", "R-RNO-5663220", "R-HSA-68877", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Domain"}, "IPR032374": {"description": "SGTA, homodimerisation domain", "go_ids": [], "go_terms": [], "name": "SGTA_dimer", "pathway_ids": ["R-MMU-9609523", "R-SCE-9609523", "R-HSA-9609523", "R-DDI-9609523", "R-SPO-9609523", "R-BTA-9609523", "R-RNO-9609523"], "pathways": ["R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Domain"}, "IPR032375": {"description": "Cerebral cavernous malformations 2, harmonin-homology domain", "go_ids": [], "go_terms": [], "name": "CCM2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032376": {"description": "Dedicator of cytokinesis, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DOCK_N", "pathway_ids": ["R-HSA-6798695", "R-MMU-8980692", "R-HSA-983231", "R-MMU-9013408", "R-HSA-2029482", "R-MMU-9013404", "R-MMU-983231", "R-HSA-418885", "R-MMU-4420097", "R-MMU-2029482", "R-HSA-8849471", "R-HSA-9013404", "R-HSA-4420097", "R-HSA-9032759", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013149", "R-MMU-9032759", "R-HSA-164944", "R-MMU-6798695", "R-HSA-9013408", "R-HSA-9664422", "R-MMU-8849471", "R-MMU-418885"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-HSA-164944:r:Nef and signal transduction", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR032377": {"description": "STAR protein, homodimerisation region", "go_ids": [], "go_terms": [], "name": "STAR_dimer", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR032378": {"description": "ZC3H15/TMA46 family, C-terminal", "go_ids": [], "go_terms": [], "name": "ZC3H15/TMA46_C", "pathway_ids": ["R-RNO-9629569", "R-MMU-9629569", "R-DDI-9629569", "R-DRE-9629569", "R-DME-9629569", "R-XTR-9629569", "R-BTA-9629569", "R-HSA-9629569"], "pathways": ["R-RNO-9629569:r:Protein hydroxylation", "R-MMU-9629569:r:Protein hydroxylation", "R-DDI-9629569:r:Protein hydroxylation", "R-DRE-9629569:r:Protein hydroxylation", "R-DME-9629569:r:Protein hydroxylation", "R-XTR-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Domain"}, "IPR032379": {"description": "Domain of unknown function DUF4874", "go_ids": [], "go_terms": [], "name": "DUF4874", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032380": {"description": "Polynucleotide kinase-phosphatase, ligase domain", "go_ids": [], "go_terms": [], "name": "PNKP_ligase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032381": {"description": "Intracellular hyaluronan-binding protein 4, N-terminal domain", "go_ids": [], "go_terms": [], "name": "IHABP4_N", "pathway_ids": ["R-HSA-114608", "R-DRE-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR032382": {"description": "Alternaria alternata allergen 1-like", "go_ids": [], "go_terms": [], "name": "AltA1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032383": {"description": "Domain of unknown function DUF4875", "go_ids": [], "go_terms": [], "name": "DUF4875", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032384": {"description": "Kinesin-like protein Kif23, Arf6-interacting domain", "go_ids": [], "go_terms": [], "name": "Kif23_Arf-bd", "pathway_ids": ["R-HSA-2132295", "R-HSA-6811434", "R-HSA-68884", "R-HSA-983189", "R-MMU-2132295", "R-MMU-68884", "R-MMU-983189", "R-MMU-6811434"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-983189:r:Kinesins", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-983189:r:Kinesins", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR032385": {"description": "T-box transcription factor-associated", "go_ids": [], "go_terms": [], "name": "T-box_assoc", "pathway_ids": ["R-HSA-9754189", "R-HSA-9827857", "R-HSA-9823730", "R-HSA-9733709", "R-HSA-9758919"], "pathways": ["R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-9827857:r:Specification of primordial germ cells", "R-HSA-9823730:r:Formation of definitive endoderm", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation"], "type": "Domain"}, "IPR032386": {"description": "Flagellar assembly protein T, middle domain", "go_ids": [], "go_terms": [], "name": "FlgT_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032387": {"description": "Acetyl-coenzyme A synthetase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ACAS_N", "pathway_ids": ["PWY-7857", "PWY-8328", "PWY-5133", "PWY-6672", "PWY-5108", "PWY-8303", "PWY-7118", "PWY-5132", "R-DDI-71384", "R-HSA-2151201", "R-DRE-77111", "R-BTA-77111", "R-RNO-77111", "R-MMU-77111", "R-DDI-77111", "R-SCE-71384", "R-HSA-71384", "R-MMU-2151201", "R-HSA-9841922", "R-SPO-71384", "R-HSA-77111", "R-DME-71384", "R-CEL-77111", "R-MMU-71384"], "pathways": ["PWY-7857:t:adlupulone and adhumulone biosynthesis", "PWY-8328:t:acetate and ATP formation from acetyl-CoA III", "PWY-5133:t:colupulone and cohumulone biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-5108:t:L-isoleucine biosynthesis V", "PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-7118:t:chitin deacetylation", "PWY-5132:t:lupulone and humulone biosynthesis", "R-DDI-71384:r:Ethanol oxidation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DRE-77111:r:Synthesis of Ketone Bodies", "R-BTA-77111:r:Synthesis of Ketone Bodies", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-DDI-77111:r:Synthesis of Ketone Bodies", "R-SCE-71384:r:Ethanol oxidation", "R-HSA-71384:r:Ethanol oxidation", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SPO-71384:r:Ethanol oxidation", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-DME-71384:r:Ethanol oxidation", "R-CEL-77111:r:Synthesis of Ketone Bodies", "R-MMU-71384:r:Ethanol oxidation"], "type": "Domain"}, "IPR032388": {"description": "Flagellar assembly protein T, C-terminal", "go_ids": [], "go_terms": [], "name": "FlgT_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032389": {"description": "Type II secretion system protein GspB, C-terminal", "go_ids": ["GO:0015627"], "go_terms": ["GO:0015627:type II protein secretion system complex:C"], "name": "GspB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032391": {"description": "IpaB/BipB/SctE, N-terminal", "go_ids": [], "go_terms": [], "name": "IpaB/BipB/SctE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032392": {"description": "SATB, ubiquitin-like oligomerisation domain", "go_ids": [], "go_terms": [], "name": "ULD", "pathway_ids": ["R-MMU-4551638", "R-MMU-111465", "R-HSA-4551638", "R-HSA-8940973", "R-CEL-4551638", "R-HSA-111465"], "pathways": ["R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Domain"}, "IPR032393": {"description": "STIM1/2, Orai1-activating region", "go_ids": [], "go_terms": [], "name": "SOAR_STIM1/2", "pathway_ids": ["R-HSA-139853", "R-CEL-983695", "R-CEL-5578775", "R-HSA-983695", "R-DME-5578775", "R-RNO-983695", "R-RNO-5578775", "R-HSA-5578775", "R-MMU-5578775", "R-DME-983695", "R-MMU-983695"], "pathways": ["R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-CEL-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-5578775:r:Ion homeostasis", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-5578775:r:Ion homeostasis", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-5578775:r:Ion homeostasis", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "type": "Domain"}, "IPR032394": {"description": "Anoctamin, dimerisation domain", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "Anoct_dimer", "pathway_ids": ["R-HSA-6798695", "R-RNO-2672351", "R-HSA-9733458", "R-MMU-2672351", "R-HSA-381753", "R-HSA-2672351", "R-MMU-6798695", "R-BTA-2672351"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-2672351:r:Stimuli-sensing channels"], "type": "Domain"}, "IPR032395": {"description": "Sf6-type phage tail needle knob", "go_ids": [], "go_terms": [], "name": "Phage_tail_NK", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032396": {"description": "Spindle assembly abnormal protein 6, N-terminal", "go_ids": [], "go_terms": [], "name": "SAS-6_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032397": {"description": "Rel homology dimerisation domain", "go_ids": [], "go_terms": [], "name": "RHD_dimer", "pathway_ids": ["R-HSA-6798695", "R-HSA-9020702", "R-HSA-4755510", "R-RNO-9020702", "R-HSA-9942503", "R-MMU-5607764", "R-DME-209560", "R-DME-5621575", "R-MMU-4086398", "R-MMU-9020702", "R-HSA-9818749", "R-HSA-5676590", "R-MMU-3134963", "R-MMU-933542", "R-RNO-2871809", "R-DME-4755510", "R-DME-933542", "R-RNO-193692", "R-RNO-448706", "R-HSA-3134963", "R-HSA-5684264", "R-MMU-445989", "R-DME-214869", "R-MMU-1810476", "R-RNO-202424", "R-DME-5676590", "R-DME-214842", "R-DME-214844", "R-GGA-1227892", "R-DME-209400", "R-MMU-5684264", "R-HSA-5603029", "R-HSA-5607761", "R-MMU-3214841", "R-HSA-209560", "R-MMU-5621575", "R-RNO-209560", "R-HSA-9660826", "R-GGA-434131", "R-HSA-9609690", "R-RNO-3214841", "R-HSA-1169091", "R-MMU-448706", "R-MMU-2871837", "R-MMU-2025928", "R-RNO-445989", "R-MMU-6798695", "R-RNO-5621575", "R-HSA-9860927", "R-DME-5607764", "R-DME-209406", "R-HSA-193692", "R-DME-2871837", "R-MMU-9860927", "R-HSA-844456", "R-DME-3134963", "R-HSA-445989", "R-HSA-8853884", "R-RNO-6798695", "R-RNO-933542", "R-DME-1169091", "R-DME-202424", "R-HSA-5607763", "R-DME-1810476", "R-HSA-933542", "R-HSA-2559582", "R-RNO-3134963", "R-DME-9860927", "R-RNO-9860927", "R-MMU-193692", "R-HSA-2871837", "R-HSA-2025928", "R-HSA-448706", "R-MMU-5607763", "R-HSA-3214841", "R-HSA-5660668", "R-RNO-2025928", "R-HSA-8877330", "R-HSA-5621575", "R-DME-5607761", "R-DME-209394", "R-DME-214416", "R-HSA-4086398", "R-HSA-5607764", "R-RNO-1810476", "R-MMU-202424", "R-DME-214411", "R-MMU-209560", "R-DME-6798695", "R-RNO-5684264", "R-HSA-381340", "R-HSA-2871809", "R-MMU-1169091", "R-GGA-434001", "R-MMU-5607761", "R-RNO-5607763", "R-MMU-5676590", "R-HSA-1810476", "R-DME-445989", "R-HSA-9909649", "R-RNO-5607764", "R-MMU-2871809", "R-RNO-1169091", "R-HSA-9692916", "R-DME-9020702", "R-DME-214399", "R-HSA-202424", "R-MMU-4755510", "R-RNO-2871837"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209560:r:NF-kB is activated and signals survival", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-4755510:r:SUMOylation of immune response proteins", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-RNO-448706:r:Interleukin-1 processing", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-202424:r:Downstream TCR signaling", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-DME-209400:r:Transcriptional activtion by phosphorylated DL/DIF dimer", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-844456:r:The NLRP3 inflammasome", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DME-202424:r:Downstream TCR signaling", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-202424:r:Downstream TCR signaling", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DME-9020702:r:Interleukin-1 signaling", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Domain"}, "IPR032398": {"description": "Infectious hypodermal and haematopoietic necrosis virus, capsid protein", "go_ids": [], "go_terms": [], "name": "IHHNV_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032399": {"description": "RelB leucine zipper", "go_ids": [], "go_terms": [], "name": "RelB_leu_zip", "pathway_ids": ["R-HSA-5607761", "R-HSA-5676590", "R-MMU-5621575", "R-HSA-5621575", "R-MMU-5676590", "R-MMU-5607761"], "pathways": ["R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling"], "type": "Domain"}, "IPR032400": {"description": "RelB transactivation domain", "go_ids": [], "go_terms": [], "name": "RelB_transact", "pathway_ids": ["R-HSA-5607761", "R-HSA-5676590", "R-MMU-5621575", "R-HSA-5621575", "R-MMU-5676590", "R-MMU-5607761"], "pathways": ["R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling"], "type": "Domain"}, "IPR032401": {"description": "Enhancer of mRNA-decapping protein 4, WD40 repeat region", "go_ids": [], "go_terms": [], "name": "EDC4_WD40", "pathway_ids": ["R-RNO-430039", "R-MMU-430039", "R-DME-430039", "R-DRE-430039", "R-HSA-430039"], "pathways": ["R-RNO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DME-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR032402": {"description": "Putative adherens-junction anchoring domain", "go_ids": [], "go_terms": [], "name": "AbLIM_anchor", "pathway_ids": ["R-HSA-5223345", "R-MMU-5223345", "R-BTA-5223345", "R-HSA-418885"], "pathways": ["R-HSA-5223345:r:Miscellaneous transport and binding events", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-BTA-5223345:r:Miscellaneous transport and binding events", "R-HSA-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR032403": {"description": "Exocyst component Exo84, C-terminal", "go_ids": [], "go_terms": [], "name": "Exo84_C", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-MMU-5620916", "R-BTA-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-BTA-264876", "R-DDI-264876", "R-SCE-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-BTA-264876:r:Insulin processing", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing"], "type": "Domain"}, "IPR032404": {"description": "Two-component sensor protein CpxA, periplasmic domain", "go_ids": [], "go_terms": [], "name": "CpxA_peri", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032405": {"description": "Kinesin-associated", "go_ids": [], "go_terms": [], "name": "Kinesin_assoc", "pathway_ids": ["R-HSA-6811434", "R-RNO-6811434", "R-HSA-5625900", "R-HSA-9696270", "R-HSA-983189", "R-RNO-983189", "R-HSA-390471", "R-MMU-5625900", "R-MMU-983189", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9696273", "R-MMU-6811434"], "pathways": ["R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-983189:r:Kinesins", "R-RNO-983189:r:Kinesins", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-983189:r:Kinesins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR032406": {"description": "Cyclic nucleotide-gated channel, C-terminal leucine zipper domain", "go_ids": [], "go_terms": [], "name": "CLZ_dom", "pathway_ids": ["R-BTA-2485179", "R-CEL-2485179", "R-MMU-5620916", "R-DME-2514859", "R-HSA-2514859", "R-RNO-5620916", "R-HSA-381753", "R-HSA-2485179", "R-RNO-2485179", "R-BTA-2514859", "R-DME-2485179", "R-CFA-2514859", "R-HSA-5620916", "R-DME-5620916", "R-MMU-2514859", "R-CEL-5620916", "R-MMU-2485179", "R-GGA-2485179", "R-CEL-2514859", "R-CFA-2485179", "R-GGA-2514859", "R-RNO-2514859"], "pathways": ["R-BTA-2485179:r:Activation of the phototransduction cascade", "R-CEL-2485179:r:Activation of the phototransduction cascade", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-2485179:r:Activation of the phototransduction cascade", "R-CFA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-GGA-2485179:r:Activation of the phototransduction cascade", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CFA-2485179:r:Activation of the phototransduction cascade", "R-GGA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Domain"}, "IPR032407": {"description": "Haemophore, haem-binding", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "MHB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032408": {"description": "Sensor histidine kinase RisS, periplasmic domain", "go_ids": [], "go_terms": [], "name": "RisS_PPD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032409": {"description": "Rho guanine nucleotide exchange factor 6/7, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "GEF6/7_CC", "pathway_ids": ["R-MMU-182971", "R-GGA-446388", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-9013149", "R-RNO-446388", "R-MMU-9013148", "R-MMU-446388", "R-MMU-8964616", "R-GGA-416482", "R-MMU-9013420", "R-RNO-416482", "R-RNO-9013424", "R-HSA-9013148", "R-RNO-9013406", "R-GGA-193648", "R-GGA-9013149", "R-RNO-193648", "R-GGA-9013420", "R-MMU-3928664", "R-HSA-193648", "R-HSA-9013420", "R-GGA-9013148", "R-HSA-8964616", "R-HSA-416482", "R-MMU-9013424", "R-RNO-9013148", "R-RNO-9013420", "R-RNO-8964616", "R-RNO-3928664", "R-HSA-9013149", "R-GGA-8964616", "R-MMU-9013406", "R-MMU-416482", "R-MMU-193648", "R-HSA-446388", "R-RNO-182971", "R-MMU-9013149"], "pathways": ["R-MMU-182971:r:EGFR downregulation", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-GGA-416482:r:G alpha (12/13) signalling events", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-GGA-193648:r:NRAGE signals death through JNK", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-RNO-193648:r:NRAGE signals death through JNK", "R-GGA-9013420:r:RHOU GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013420:r:RHOU GTPase cycle", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-RNO-182971:r:EGFR downregulation", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR032410": {"description": "ATP-binding cassette sub-family B member 6, N-terminal five TM domain", "go_ids": [], "go_terms": [], "name": "ABCB6_N", "pathway_ids": ["R-HSA-5683371", "R-RNO-1369007", "R-MMU-1369007", "R-HSA-1369007"], "pathways": ["R-HSA-5683371:r:Defective ABCB6 causes MCOPCB7", "R-RNO-1369007:r:Mitochondrial ABC transporters", "R-MMU-1369007:r:Mitochondrial ABC transporters", "R-HSA-1369007:r:Mitochondrial ABC transporters"], "type": "Domain"}, "IPR032411": {"description": "Flagellar FLiS export co-chaperone, HP1076", "go_ids": [], "go_terms": [], "name": "FliS_cochap", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032412": {"description": "Myosin VI, cargo binding domain", "go_ids": [], "go_terms": [], "name": "Myosin-VI_CBD", "pathway_ids": ["R-MMU-9013422", "R-HSA-9013420", "R-DME-190873", "R-MMU-190873", "R-MMU-9013420", "R-HSA-9013422", "R-HSA-399719", "R-HSA-9013418", "R-HSA-190873", "R-DME-9013422", "R-MMU-399719", "R-DME-9013418", "R-DME-9013420", "R-MMU-9013418"], "pathways": ["R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DME-190873:r:Gap junction degradation", "R-MMU-190873:r:Gap junction degradation", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-190873:r:Gap junction degradation", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle"], "type": "Domain"}, "IPR032413": {"description": "Atypical Arm repeat", "go_ids": [], "go_terms": [], "name": "Arm_3", "pathway_ids": ["R-HSA-140342", "R-HSA-180910", "R-HSA-9636249", "R-SPO-68616", "R-HSA-442729", "R-HSA-9705671", "R-HSA-168276", "R-BTA-68616", "R-BTA-140342", "R-MMU-5693548", "R-HSA-168271", "R-HSA-9918432", "R-DDI-909733", "R-HSA-1169408", "R-RNO-140342", "R-CEL-909733", "R-HSA-68616", "R-MMU-140342", "R-HSA-162592", "R-RNO-68616", "R-HSA-909733", "R-BTA-909733", "R-RNO-909733", "R-HSA-9692916", "R-MMU-68616", "R-HSA-111932", "R-DME-5693548", "R-HSA-5693548", "R-MMU-909733", "R-HSA-9018519"], "pathways": ["R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-162592:r:Integration of provirus", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Repeat"}, "IPR032414": {"description": "Matrix protein, Bornaviridae", "go_ids": [], "go_terms": [], "name": "BDV_M", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032415": {"description": "TRPM, tetramerisation domain", "go_ids": ["GO:0051262"], "go_terms": ["GO:0051262:protein tetramerization:P"], "name": "TRPM_tetra", "pathway_ids": ["R-DME-3295583", "R-RNO-3295583", "R-HSA-9824594", "R-MMU-3295583", "R-HSA-3295583"], "pathways": ["R-DME-3295583:r:TRP channels", "R-RNO-3295583:r:TRP channels", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-MMU-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Domain"}, "IPR032416": {"description": "Peptidase M24, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Peptidase_M24_C", "pathway_ids": ["R-DDI-163125", "R-MMU-163125", "R-SCE-163125", "R-RNO-163125", "R-HSA-163125"], "pathways": ["R-DDI-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-SCE-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Domain"}, "IPR032417": {"description": "T3SS negative regulator GrlR", "go_ids": [], "go_terms": [], "name": "GrlR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032418": {"description": "Ubiquitin-activating enzyme E1, FCCH domain", "go_ids": [], "go_terms": [], "name": "E1_FCCH", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-MMU-9909505", "R-HSA-8866652", "R-BTA-8866652", "R-MMU-983168", "R-HSA-9918485", "R-SPO-983168", "R-RNO-8866652", "R-RNO-983168", "R-MMU-5656169", "R-SCE-983168", "R-HSA-983168", "R-MMU-8866652", "R-MMU-1169408"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-1169408:r:ISG15 antiviral mechanism"], "type": "Domain"}, "IPR032419": {"description": "NF-kappa-B essential modulator NEMO, CC2-LZ domain", "go_ids": [], "go_terms": [], "name": "CC2-LZ_dom", "pathway_ids": ["R-MMU-9909505", "R-RNO-9758274", "R-HSA-9020702", "R-HSA-4755510", "R-SSC-937039", "R-HSA-168638", "R-BTA-5689880", "R-HSA-9833482", "R-HSA-5689880", "R-MMU-9020702", "R-SSC-5357905", "R-BTA-975144", "R-MMU-5689896", "R-MMU-933542", "R-MMU-8854214", "R-SSC-9833482", "R-MMU-5689880", "R-BTA-450321", "R-HSA-5684264", "R-BTA-1169091", "R-HSA-168927", "R-MMU-1810476", "R-HSA-450302", "R-SSC-9909505", "R-HSA-937041", "R-SSC-2565942", "R-SSC-975144", "R-SSC-450321", "R-MMU-975144", "R-RNO-975144", "R-BTA-4755510", "R-HSA-9758274", "R-SSC-450302", "R-MMU-450321", "R-RNO-936964", "R-DRE-5205685", "R-BTA-5684264", "R-MMU-9860276", "R-RNO-5689880", "R-SSC-9860276", "R-DRE-5357905", "R-BTA-1810476", "R-DRE-8854214", "R-MMU-5357905", "R-HSA-1236974", "R-SSC-168638", "R-DME-9909505", "R-BTA-9833482", "R-MMU-9860927", "R-DME-202424", "R-HSA-9705671", "R-RNO-9860276", "R-MMU-450302", "R-SSC-936964", "R-HSA-8854214", "R-BTA-5357956", "R-HSA-933542", "R-HSA-9824878", "R-RNO-450321", "R-DME-2565942", "R-MMU-5357956", "R-RNO-9860927", "R-DME-937039", "R-BTA-2871837", "R-SSC-8854214", "R-HSA-5357905", "R-RNO-2565942", "R-SSC-933542", "R-BTA-445989", "R-SSC-9020702", "R-SSC-9860927", "R-MMU-202424", "R-MMU-9824878", "R-RNO-937041", "R-MMU-936964", "R-DME-5357905", "R-SSC-5607764", "R-MMU-1169091", "R-RNO-9824878", "R-SSC-937041", "R-SSC-202424", "R-DME-9833482", "R-DME-445989", "R-HSA-5357956", "R-SSC-9758274", "R-DRE-2565942", "R-HSA-933543", "R-DME-214399", "R-DME-9020702", "R-BTA-5357905", "R-RNO-9833482", "R-MMU-937041", "R-DME-5689880", "R-HSA-937039", "R-BTA-9909505", "R-RNO-8854214", "R-RNO-9020702", "R-MMU-5607764", "R-HSA-5689896", "R-BTA-202424", "R-HSA-9828211", "R-SSC-1810476", "R-RNO-5357905", "R-MMU-5205685", "R-MMU-2565942", "R-DME-933542", "R-HSA-936964", "R-HSA-450321", "R-MMU-9833482", "R-SSC-5684264", "R-MMU-445989", "R-BTA-9758274", "R-BTA-937041", "R-RNO-202424", "R-HSA-5205685", "R-SSC-445989", "R-MMU-5684264", "R-HSA-5603029", "R-RNO-5205685", "R-DRE-936964", "R-SSC-1169091", "R-DRE-9824878", "R-HSA-975144", "R-SSC-9824878", "R-HSA-5357786", "R-HSA-5602636", "R-HSA-9860276", "R-HSA-1169091", "R-MMU-2871837", "R-BTA-933542", "R-RNO-450302", "R-DME-209447", "R-RNO-445989", "R-RNO-168638", "R-HSA-9860927", "R-RNO-5689896", "R-DME-5607764", "R-BTA-937039", "R-DME-2871837", "R-RNO-933542", "R-HSA-445989", "R-DME-1169091", "R-SSC-5205685", "R-DME-1810476", "R-RNO-9909505", "R-DME-9860927", "R-HSA-9909505", "R-HSA-2565942", "R-SSC-4755510", "R-HSA-2871837", "R-MMU-937039", "R-SSC-5689880", "R-MMU-168638", "R-BTA-168638", "R-HSA-5607764", "R-RNO-1810476", "R-RNO-937039", "R-DME-975144", "R-DME-8854214", "R-BTA-5689896", "R-HSA-9013973", "R-RNO-5684264", "R-BTA-9860276", "R-DME-9758274", "R-RNO-4755510", "R-SSC-5357956", "R-SSC-2871837", "R-HSA-1810476", "R-BTA-9860927", "R-HSA-5603027", "R-RNO-5607764", "R-DME-5205685", "R-BTA-450302", "R-RNO-1169091", "R-BTA-9020702", "R-RNO-5357956", "R-BTA-5607764", "R-MMU-9758274", "R-HSA-202424", "R-MMU-4755510", "R-RNO-2871837"], "pathways": ["R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-SSC-937039:r:IRAK1 recruits IKK complex", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-9020702:r:Interleukin-1 signaling", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-8854214:r:TBC/RABGAPs", "R-SSC-9833482:r:PKR-mediated signaling", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SSC-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SSC-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-BTA-4755510:r:SUMOylation of immune response proteins", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DRE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-SSC-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DRE-8854214:r:TBC/RABGAPs", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-168638:r:NOD1/2 Signaling Pathway", "R-DME-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-9833482:r:PKR-mediated signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-202424:r:Downstream TCR signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SSC-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-8854214:r:TBC/RABGAPs", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-SSC-8854214:r:TBC/RABGAPs", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9020702:r:Interleukin-1 signaling", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-202424:r:Downstream TCR signaling", "R-DME-9833482:r:PKR-mediated signaling", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-9758274:r:Regulation of NF-kappa B signaling", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-9020702:r:Interleukin-1 signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-9833482:r:PKR-mediated signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-8854214:r:TBC/RABGAPs", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-SSC-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-9833482:r:PKR-mediated signaling", "R-SSC-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DRE-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-DRE-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SSC-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5602636:r:IKBKB deficiency causes SCID", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-SSC-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-4755510:r:SUMOylation of immune response proteins", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-SSC-5689880:r:Ub-specific processing proteases", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DME-8854214:r:TBC/RABGAPs", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-4755510:r:SUMOylation of immune response proteins", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5603027:r:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Domain"}, "IPR032420": {"description": "Ubiquitin-activating enzyme E1, four-helix bundle", "go_ids": [], "go_terms": [], "name": "E1_4HB", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-MMU-9909505", "R-HSA-8866652", "R-BTA-8866652", "R-MMU-983168", "R-HSA-9918485", "R-SPO-983168", "R-RNO-8866652", "R-RNO-983168", "R-MMU-5656169", "R-SCE-983168", "R-HSA-983168", "R-MMU-8866652", "R-MMU-1169408"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-1169408:r:ISG15 antiviral mechanism"], "type": "Domain"}, "IPR032421": {"description": "Protein O-mannosyl-transferase, C-terminal four TM domain", "go_ids": [], "go_terms": [], "name": "PMT_4TMC", "pathway_ids": ["PWY-7922", "PWY-7921", "PWY-7979", "R-DRE-8932506", "R-MMU-8932505", "R-HSA-8932505", "R-DRE-9768727", "R-RNO-8932506", "R-HSA-8932504", "R-HSA-5083633", "R-RNO-8932504", "R-DME-8932506", "R-DRE-8932505", "R-DME-8932504", "R-DRE-8932504", "R-HSA-8932506", "R-DME-8932505", "R-HSA-9768727", "R-MMU-8932504", "R-HSA-5083629", "R-RNO-9768727", "R-MMU-9768727", "R-MMU-8932506", "R-RNO-8932505"], "pathways": ["PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-7979:t:protein O-mannosylation III (mammals, core M3)", "R-DRE-8932506:r:DAG1 core M1 glycosylations", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-8932506:r:DAG1 core M1 glycosylations", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-5083633:r:Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "R-RNO-8932504:r:DAG1 core M2 glycosylations", "R-DME-8932506:r:DAG1 core M1 glycosylations", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-DME-8932504:r:DAG1 core M2 glycosylations", "R-DRE-8932504:r:DAG1 core M2 glycosylations", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-DME-8932505:r:DAG1 core M3 glycosylations", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-HSA-5083629:r:Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-8932506:r:DAG1 core M1 glycosylations", "R-RNO-8932505:r:DAG1 core M3 glycosylations"], "type": "Domain"}, "IPR032422": {"description": "Huntingtin-interacting protein 1, clathrin-binding domain", "go_ids": [], "go_terms": [], "name": "HIP1_clath-bd", "pathway_ids": ["R-MMU-8856828", "R-HSA-9700645", "R-HSA-432722", "R-HSA-9725370", "R-HSA-8856828", "R-MMU-432722"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR032423": {"description": "AAA C-terminal domain", "go_ids": [], "go_terms": [], "name": "AAA_assoc_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032424": {"description": "Putative NADH-ubiquinone oxidoreductase chain E", "go_ids": [], "go_terms": [], "name": "NADH-UOR_E", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032425": {"description": "Talin, N-terminal F0 domain", "go_ids": [], "go_terms": [], "name": "FERM_f0", "pathway_ids": ["R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-9656223", "R-MMU-399955", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-DDI-114608", "R-DDI-9013149", "R-HSA-6794361", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-DDI-9013423", "R-DDI-9013404", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR032426": {"description": "SUMO-activating enzyme subunit 2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "UBA2_C", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-DRE-3065676", "R-HSA-3065676", "R-MMU-3065678", "R-MMU-3065676", "R-HSA-3065678", "R-DRE-3065678"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-HSA-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-MMU-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-MMU-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-HSA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DRE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "type": "Domain"}, "IPR032427": {"description": "Phage P22-like portal protein", "go_ids": [], "go_terms": [], "name": "P22_portal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032428": {"description": "TrfB transcriptional repressor protein", "go_ids": [], "go_terms": [], "name": "TrfB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032429": {"description": "Nibrin, second BRCT domain", "go_ids": [], "go_terms": [], "name": "Nibrin_BRCT2", "pathway_ids": ["R-DRE-5693607", "R-HSA-5685942", "R-MMU-5693571", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5693565", "R-GGA-351433", "R-RNO-5685939", "R-MMU-6804756", "R-HSA-5693565", "R-DRE-5685939", "R-RNO-5693548", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-5693565", "R-MMU-69473", "R-DRE-5693568", "R-DRE-5693571", "R-HSA-9709570", "R-HSA-5693607", "R-DRE-2559586", "R-GGA-351444", "R-RNO-5685938", "R-HSA-912446", "R-MMU-5685939", "R-RNO-6804756", "R-MMU-5693568", "R-GGA-351442", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-RNO-2559586", "R-GGA-217106", "R-MMU-5693548", "R-RNO-5693579", "R-HSA-69473", "R-MMU-2559586", "R-RNO-5693607", "R-HSA-9709603", "R-DRE-5685942", "R-MMU-5685942", "R-RNO-5693571", "R-HSA-5685939", "R-RNO-69473", "R-RNO-5685942", "R-DRE-5693548", "R-HSA-5693571", "R-HSA-6804756", "R-HSA-9704331", "R-DRE-69473", "R-RNO-5693568", "R-DRE-5693616", "R-DRE-5693565", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-HSA-5693579", "R-HSA-2559586", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR032430": {"description": "Proteasome activator Blm10, middle HEAT repeats region", "go_ids": [], "go_terms": [], "name": "Blm10_mid", "pathway_ids": ["R-HSA-9907900"], "pathways": ["R-HSA-9907900:r:Proteasome assembly"], "type": "Domain"}, "IPR032432": {"description": "Radical SAM, C-terminal extension", "go_ids": [], "go_terms": [], "name": "Radical_SAM_C", "pathway_ids": ["PWY-6829", "PWY-7888", "R-HSA-3214847"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "R-HSA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR032433": {"description": "Putative virion glycoprotein, N-terminal", "go_ids": [], "go_terms": [], "name": "DiSB-ORF2_chro", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032434": {"description": "Emaravirus P4 movement protein", "go_ids": [], "go_terms": [], "name": "Emaravirus_P4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032435": {"description": "STML2-like, C-terminal extension", "go_ids": [], "go_terms": [], "name": "STML2-like_C", "pathway_ids": ["R-HSA-9840373", "R-RNO-9840373", "R-HSA-8949664", "R-RNO-8949664", "R-MMU-8949664", "R-MMU-9840373"], "pathways": ["R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-8949664:r:Processing of SMDT1", "R-RNO-8949664:r:Processing of SMDT1", "R-MMU-8949664:r:Processing of SMDT1", "R-MMU-9840373:r:Cellular response to mitochondrial stress"], "type": "Domain"}, "IPR032436": {"description": "URB1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "URB1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032437": {"description": "RecQ-like DNA helicase BLM, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BLM_N", "pathway_ids": ["R-HSA-3108214", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-174414", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-MMU-174414", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-MMU-5693568", "R-MMU-3108214", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192"], "pathways": ["R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR032438": {"description": "ERCC3/RAD25/XPB helicase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ERCC3_RAD25_C", "pathway_ids": ["R-RNO-6781823", "R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-RNO-73779", "R-HSA-427413", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-RNO-73776", "R-DRE-75955", "R-SPO-76042", "R-HSA-73776", "R-DME-72086", "R-BTA-77075", "R-DDI-674695", "R-SPO-6796648", "R-DME-75953", "R-DME-6782135", "R-BTA-73863", "R-BTA-75955", "R-DRE-6782210", "R-BTA-75953", "R-BTA-6782135", "R-RNO-5696395", "R-HSA-167161", "R-DME-112382", "R-HSA-5696395", "R-DDI-77075", "R-HSA-167160", "R-DDI-113418", "R-SPO-73779", "R-MMU-73772", "R-MMU-72086", "R-BTA-6782210", "R-BTA-73776", "R-SPO-73776", "R-BTA-73772", "R-SCE-73776", "R-DDI-5696395", "R-HSA-6781827", "R-DRE-5696400", "R-DME-73779", "R-DME-77075", "R-DME-73776", "R-MMU-6781823", "R-BTA-6781823", "R-DDI-73772", "R-DDI-6796648", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696400", "R-HSA-167172", "R-DRE-6781823", "R-MMU-5696400", "R-BTA-73779", "R-SCE-73779", "R-DME-113418", "R-RNO-113418", "R-MMU-6796648", "R-RNO-6796648", "R-DRE-73772", "R-RNO-75955", "R-SCE-6781823", "R-DME-5696395", "R-BTA-674695", "R-DRE-73776", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-DRE-6782135", "R-MMU-77075", "R-HSA-75955", "R-DME-5696400", "R-SPO-6782210", "R-RNO-5696400", "R-HSA-5696400", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-SCE-73772", "R-HSA-112382", "R-HSA-73779", "R-RNO-674695", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-DRE-73779", "R-BTA-76042", "R-RNO-73863", "R-DRE-75953", "R-HSA-6796648", "R-HSA-6781823", "R-SPO-5696395", "R-HSA-167246", "R-MMU-5696395", "R-DRE-6796648", "R-DRE-113418", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-RNO-6782210", "R-SPO-113418", "R-DDI-73779", "R-DME-674695", "R-BTA-72086", "R-RNO-76042", "R-DDI-6781823", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-SCE-76042", "R-HSA-167200", "R-RNO-112382", "R-SCE-674695", "R-MMU-6782210", "R-RNO-75953", "R-SCE-6782135", "R-DDI-6782135", "R-MMU-73762", "R-MMU-6782135", "R-BTA-113418", "R-DME-6796648", "R-HSA-72086", "R-HSA-167162", "R-DRE-5696395", "R-DRE-73863", "R-DRE-77075", "R-GGA-353303", "R-HSA-167152", "R-HSA-113418", "R-BTA-5696395", "R-SCE-6782210", "R-BTA-6796648", "R-SCE-6796648", "R-BTA-73762", "R-RNO-72086", "R-SPO-77075", "R-RNO-73772", "R-DRE-76042", "R-SCE-113418", "R-SCE-72086", "R-RNO-6782135", "R-MMU-73863", "R-DRE-72086", "R-HSA-6782135", "R-HSA-73762", "R-DRE-674695", "R-SPO-5696400", "R-SCE-77075", "R-DDI-75953", "R-SPO-6782135", "R-DME-73772"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72086:r:mRNA Capping", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-6782135:r:Dual incision in TC-NER", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-6782135:r:Dual incision in TC-NER", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72086:r:mRNA Capping", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-73772:r:RNA Polymerase I Promoter Escape"], "type": "Domain"}, "IPR032439": {"description": "RecQ-like DNA helicase BLM, BDHCT-box associated domain", "go_ids": [], "go_terms": [], "name": "BDHCT_assoc", "pathway_ids": ["R-HSA-3108214", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-174414", "R-HSA-69473", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-9709603", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-MMU-174414", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-912446", "R-MMU-5693568", "R-MMU-3108214", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192"], "pathways": ["R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR032440": {"description": "Small ribosomal subunit protein uS17, N-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_uS17_N", "pathway_ids": ["R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553", "R-DME-6791226", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-HSA-72695", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-BTA-72689", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-BTA-72695", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-DDI-72695", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-RNO-6791226", "R-RNO-72649", "R-HSA-6791226", "R-RNO-975956", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-SPO-72689", "R-DDI-72702", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-DME-72649", "R-HSA-156827", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-SCE-156827", "R-MMU-72702", "R-DME-72695", "R-DME-975956", "R-DME-975957", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-HSA-9754678", "R-HSA-72649", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-SCE-72649", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-72649:r:Translation initiation complex formation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72649:r:Translation initiation complex formation", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR032441": {"description": "SP24", "go_ids": [], "go_terms": [], "name": "SP24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032442": {"description": "Cytoplasmic tRNA 2-thiolation protein 1, C-terminal", "go_ids": [], "go_terms": [], "name": "CTU1_C", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-HSA-6782315"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR032443": {"description": "RAWUL domain", "go_ids": [], "go_terms": [], "name": "RAWUL", "pathway_ids": ["R-HSA-4655427", "R-MMU-8953750", "R-GGA-3899300", "R-GGA-8939243", "R-DME-8939243", "R-RNO-8943724", "R-GGA-2559580", "R-HSA-3108214", "R-HSA-2559580", "R-GGA-3108214", "R-CFA-8939243", "R-DRE-2559580", "R-MMU-4570464", "R-BTA-4570464", "R-RNO-8953750", "R-DRE-8953750", "R-BTA-3899300", "R-DRE-8939243", "R-BTA-3108214", "R-HSA-8953750", "R-RNO-3108214", "R-GGA-4551638", "R-RNO-8939243", "R-DRE-4570464", "R-DME-2559580", "R-DRE-3108214", "R-MMU-4551638", "R-DME-4570464", "R-GGA-8943724", "R-CFA-8943724", "R-HSA-8943724", "R-DME-3899300", "R-HSA-4570464", "R-DME-8953750", "R-BTA-8953750", "R-HSA-4551638", "R-DME-3108214", "R-RNO-3899300", "R-BTA-8943724", "R-GGA-4570464", "R-BTA-2559580", "R-MMU-3899300", "R-BTA-4551638", "R-MMU-8939243", "R-DRE-3899300", "R-MMU-8943724", "R-RNO-4551638", "R-HSA-8939243", "R-RNO-2559580", "R-GGA-8953750", "R-RNO-4570464", "R-BTA-8939243", "R-CFA-2559580", "R-MMU-3108214", "R-HSA-3899300", "R-DME-8943724", "R-HSA-5617472", "R-CFA-8953750"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", 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"type": "Domain"}, "IPR032472": {"description": "Argonaute linker 2 domain", "go_ids": [], "go_terms": [], "name": "ArgoL2", "pathway_ids": ["R-HSA-8853884", "R-HSA-426486", "R-SPO-426496", "R-RNO-203927", "R-MMU-426496", "R-HSA-2559580", "R-HSA-9022692", "R-HSA-8936459", "R-HSA-5578749", "R-HSA-2559585", "R-HSA-8948700", "R-DME-5578749", "R-HSA-5628897", "R-HSA-1912408", "R-XTR-426496", "R-HSA-9764562", "R-DRE-426496", "R-SPO-5578749", "R-SPO-426486", "R-HSA-203927", "R-CEL-203927", "R-HSA-9759811", "R-HSA-4086398", "R-HSA-9824594", "R-HSA-9029569", "R-HSA-9018519", "R-XTR-5578749", "R-CEL-426486", "R-MMU-5578749", "R-HSA-9839394", "R-HSA-8943723", "R-RNO-426496", "R-HSA-8934593", "R-RNO-5578749", "R-MMU-426486", "R-RNO-426486", "R-HSA-9725371", "R-MMU-203927", "R-HSA-9768778", "R-DME-203927", "R-HSA-5687128", "R-XTR-426486", "R-HSA-9820841", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-426496", "R-DME-426496", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-HSA-8853884:r:Transcriptional 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regulation by small RNAs", "R-SPO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-XTR-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-RNO-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR032474": {"description": "Protein argonaute, N-terminal", "go_ids": [], "go_terms": [], "name": "Argonaute_N", "pathway_ids": ["R-HSA-8853884", "R-HSA-426486", "R-SPO-426496", "R-RNO-203927", "R-MMU-426496", "R-HSA-2559580", "R-HSA-9022692", "R-HSA-8936459", "R-HSA-5578749", "R-HSA-2559585", "R-HSA-8948700", "R-DME-5578749", "R-HSA-5628897", "R-HSA-1912408", "R-XTR-426496", "R-HSA-9764562", "R-DRE-426496", "R-SPO-5578749", "R-SPO-426486", "R-HSA-203927", "R-CEL-203927", "R-HSA-9759811", "R-HSA-4086398", "R-HSA-9824594", "R-HSA-9029569", "R-HSA-9018519", "R-XTR-5578749", "R-CEL-426486", "R-MMU-5578749", "R-HSA-9839394", "R-HSA-8943723", "R-RNO-426496", "R-HSA-8934593", "R-RNO-5578749", "R-MMU-426486", "R-RNO-426486", "R-HSA-9725371", "R-MMU-203927", "R-HSA-9768778", "R-DME-203927", "R-HSA-5687128", "R-XTR-426486", "R-HSA-9820841", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-426496", "R-DME-426496", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-SPO-426496:r:Post-transcriptional silencing by small RNAs", "R-RNO-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-XTR-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-DRE-426496:r:Post-transcriptional silencing by small RNAs", "R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-XTR-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-RNO-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR032475": {"description": "Protealysin, N-terminal propeptide", "go_ids": [], "go_terms": [], "name": "Protealysin_N_PP", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR032476": {"description": "Carnitine O-palmitoyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "CPT_N", "pathway_ids": ["PWY-6111", "R-BTA-200425", "R-HSA-1989781", "R-HSA-9933387", "R-HSA-200425", "R-MMU-200425", "R-RNO-200425"], "pathways": ["PWY-6111:t:mitochondrial L-carnitine shuttle", "R-BTA-200425:r:Carnitine shuttle", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-200425:r:Carnitine shuttle", "R-MMU-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle"], "type": "Domain"}, "IPR032477": {"description": "Glycoside hydrolase 64", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_64", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032478": {"description": "Staufen, C-terminal", "go_ids": [], "go_terms": [], "name": "Staufen_C", "pathway_ids": ["R-DRE-9833482"], "pathways": ["R-DRE-9833482:r:PKR-mediated signaling"], "type": "Domain"}, "IPR032479": {"description": "Protein of unknown function DUF5058", "go_ids": [], "go_terms": [], "name": "DUF5058", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032480": {"description": "Domain of unknown function DUF5057", "go_ids": [], "go_terms": [], "name": "DUF5057", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032481": {"description": "Protein of unknown function DUF5055", "go_ids": [], "go_terms": [], "name": "DUF5055", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032482": {"description": "Protein of unknown function DUF5054", "go_ids": [], "go_terms": [], "name": "DUF5054", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032483": {"description": "Protein of unknown function DUF5053", "go_ids": [], "go_terms": [], "name": "DUF5053", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032484": {"description": "Protein of unknown function DUF5052", "go_ids": [], "go_terms": [], "name": "DUF5052", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032485": {"description": "Prolow-density lipoprotein receptor-related protein 1-like, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "LRP1-like_beta_prop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032486": {"description": "JNK-interacting protein, leucine zipper II", "go_ids": [], "go_terms": [], "name": "JIP_LZII", "pathway_ids": ["R-HSA-525793", "R-MMU-525793", "R-CEL-525793", "R-DME-525793"], "pathways": ["R-HSA-525793:r:Myogenesis", "R-MMU-525793:r:Myogenesis", "R-CEL-525793:r:Myogenesis", "R-DME-525793:r:Myogenesis"], "type": "Domain"}, "IPR032487": {"description": "Polyprotein allergen, nematode", "go_ids": [], "go_terms": [], "name": "ABA-1_nematode", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032488": {"description": "Protein of unknown function DUF5049", "go_ids": [], "go_terms": [], "name": "DUF5049", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032489": {"description": "Domain of unknown function DUF5048", "go_ids": [], "go_terms": [], "name": "DUF5048", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032490": {"description": "Domain of unknown function DUF5047", "go_ids": [], "go_terms": [], "name": "DUF5047", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032491": {"description": "Domain of unknown function DUF5046", "go_ids": [], "go_terms": [], "name": "DUF5046", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032492": {"description": "Domain of unknown function DUF5045", "go_ids": [], "go_terms": [], "name": "DUF5045", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032493": {"description": "Phage tail tube protein family", "go_ids": [], "go_terms": [], "name": "Phage_TTP_13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032494": {"description": "Lambda phage tail tube protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_TTP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032495": {"description": "Phage tail tube protein, lambda-like", "go_ids": [], "go_terms": [], "name": "Phage_TTP_11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032496": {"description": "Hemolysin, beta-prism lectin", "go_ids": [], "go_terms": [], "name": "Hemolysin_beta-prism_lec", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032497": {"description": "Uncharacterised protein YmgD", "go_ids": [], "go_terms": [], "name": "YmgD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032498": {"description": "PI3K regulatory subunit p85-related , inter-SH2 domain", "go_ids": [], "go_terms": [], "name": "PI3K_P85_iSH2", "pathway_ids": ["R-RNO-9013026", "R-HSA-9842640", "R-HSA-9013405", "R-MMU-1250342", "R-BTA-198203", "R-MMU-6811558", "R-MMU-5654720", "R-BTA-5673001", "R-RNO-9013409", "R-HSA-912631", "R-BTA-8851907", "R-RNO-512988", "R-BTA-5654710", "R-RNO-912631", "R-HSA-5654695", "R-MMU-201556", "R-BTA-4420097", "R-BTA-6811558", "R-HSA-512988", "R-RNO-416476", "R-MMU-186763", "R-MMU-9035034", "R-HSA-983695", "R-RNO-9013148", "R-MMU-912526", "R-MMU-1963642", "R-RNO-2730905", "R-HSA-389357", "R-BTA-8980692", "R-MMU-9696264", "R-RNO-9013420", "R-BTA-5654689", "R-HSA-9680350", "R-BTA-1660499", "R-BTA-430116", "R-RNO-1257604", "R-RNO-8980692", "R-BTA-9927354", "R-HSA-9013148", "R-HSA-1963642", "R-HSA-112399", "R-BTA-180292", "R-HSA-5655332", "R-HSA-9696270", "R-HSA-109704", "R-MMU-9013424", "R-MMU-1257604", "R-HSA-9842663", "R-RNO-5654689", "R-RNO-9013423", "R-HSA-9009391", "R-BTA-983695", "R-BTA-9696264", "R-MMU-8851907", "R-RNO-983695", "R-BTA-210993", "R-BTA-9027276", "R-MMU-9696273", "R-HSA-9725370", "R-MMU-416476", "R-HSA-180292", "R-MMU-9013106", "R-BTA-202424", "R-MMU-4420097", "R-HSA-9670439", "R-RNO-9027276", "R-RNO-912526", "R-MMU-389357", "R-RNO-198203", "R-MMU-5654695", "R-BTA-9013409", "R-BTA-8853659", "R-HSA-9673767", "R-MMU-2029485", "R-BTA-112399", "R-HSA-9013408", "R-RNO-9013404", "R-RNO-9013408", "R-RNO-5673001", "R-HSA-1266695", "R-RNO-9927354", "R-HSA-9927354", "R-HSA-373753", "R-MMU-1433557", "R-MMU-180292", "R-HSA-210993", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-MMU-9027276", "R-HSA-1257604", "R-MMU-5654710", "R-BTA-5654720", "R-RNO-109704", "R-MMU-9013148", "R-HSA-1660499", "R-MMU-9842663", "R-BTA-186763", "R-MMU-198203", "R-HSA-9673770", "R-BTA-201556", "R-HSA-9035034", "R-BTA-2029485", "R-BTA-9013420", "R-RNO-1266695", "R-HSA-186763", "R-RNO-2424491", "R-MMU-9927354", "R-HSA-5654710", "R-HSA-202424", "R-HSA-9013409", "R-HSA-9607240", "R-MMU-1266695", "R-BTA-9696273", "R-MMU-114604", "R-HSA-9918485", "R-MMU-9013408", "R-RNO-9607240", "R-RNO-9009391", "R-MMU-9013409", "R-MMU-9009391", "R-MMU-210993", "R-BTA-1963642", "R-MMU-9013420", "R-RNO-6811558", "R-HSA-8853659", "R-HSA-9603381", "R-RNO-1963642", "R-MMU-5673001", "R-HSA-114604", "R-RNO-210993", "R-HSA-5654689", "R-HSA-2424491", "R-HSA-5637810", "R-HSA-9696264", "R-MMU-9013423", "R-RNO-9696264", "R-HSA-9013026", "R-MMU-2730905", "R-BTA-2424491", "R-RNO-8851907", "R-HSA-1839117", "R-HSA-5655253", "R-RNO-9842663", "R-MMU-430116", "R-RNO-9035034", "R-MMU-8980692", "R-HSA-2029485", "R-HSA-9013106", "R-HSA-9665348", "R-BTA-9013148", "R-BTA-9013423", "R-HSA-9013423", "R-BTA-1266695", "R-BTA-5654695", "R-HSA-8851907", "R-BTA-912526", "R-HSA-9028335", "R-MMU-512988", "R-HSA-2730905", "R-HSA-9027276", "R-BTA-512988", "R-MMU-202424", "R-BTA-1433557", "R-HSA-5655291", "R-MMU-912631", "R-MMU-109704", "R-BTA-9696270", "R-RNO-1250342", "R-BTA-9009391", "R-MMU-1660499", "R-BTA-109704", "R-RNO-1660499", "R-RNO-5654695", "R-HSA-912526", "R-HSA-201556", "R-BTA-9013404", "R-BTA-1257604", "R-HSA-9856530", "R-BTA-9607240", "R-MMU-5654689", "R-MMU-9013149", "R-BTA-389357", "R-MMU-9607240", "R-BTA-9013424", "R-RNO-5654710", "R-HSA-430116", "R-RNO-9013149", "R-MMU-9013404", "R-HSA-9013424", "R-BTA-9035034", "R-HSA-4420097", "R-RNO-112399", "R-RNO-2029485", "R-RNO-9013424", "R-RNO-202424", "R-HSA-9664565", "R-HSA-5655302", "R-RNO-389357", "R-RNO-201556", "R-RNO-8853659", "R-MMU-8853659", "R-HSA-2219530", "R-RNO-9696273", "R-BTA-912631", "R-HSA-6785807", "R-HSA-9013404", "R-BTA-416476", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-9703648", "R-HSA-5654720", "R-BTA-114604", "R-HSA-198203", "R-BTA-9013106", "R-RNO-4420097", "R-RNO-430116", "R-RNO-9696270", "R-HSA-416476", "R-HSA-1250342", "R-HSA-1236382", "R-RNO-9013106", "R-HSA-9013420", "R-BTA-1250342", "R-MMU-983695", "R-HSA-1433557", "R-RNO-180292", "R-MMU-112399", "R-BTA-9013408", "R-HSA-9703465", "R-BTA-2730905", "R-RNO-114604", "R-MMU-9013026", "R-RNO-5654720", "R-MMU-2424491", "R-MMU-9696270", "R-RNO-186763", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-BTA-198203:r:PI3K/AKT activation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-912631:r:Regulation of signaling by CBL", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-912631:r:Regulation of signaling by CBL", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-201556:r:Signaling by ALK", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-430116:r:GP1b-IX-V activation signalling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-112399:r:IRS-mediated signalling", "R-BTA-180292:r:GAB1 signalosome", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-109704:r:PI3K Cascade", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-9696264:r:RND3 GTPase cycle", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-210993:r:Tie2 Signaling", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-BTA-9013409:r:RHOJ GTPase cycle", "R-BTA-8853659:r:RET signaling", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-112399:r:IRS-mediated signalling", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-373753:r:Nephrin family interactions", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-109704:r:PI3K Cascade", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-9842663:r:Signaling by LTK", "R-BTA-186763:r:Downstream signal transduction", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-BTA-201556:r:Signaling by ALK", "R-HSA-9035034:r:RHOF GTPase cycle", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-2424491:r:DAP12 signaling", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9607240:r:FLT3 Signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9607240:r:FLT3 Signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-210993:r:Tie2 Signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-BTA-2424491:r:DAP12 signaling", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-RNO-9842663:r:Signaling by LTK", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-BTA-1266695:r:Interleukin-7 signaling", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-912631:r:Regulation of signaling by CBL", "R-MMU-109704:r:PI3K Cascade", "R-BTA-9696270:r:RND2 GTPase cycle", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-109704:r:PI3K Cascade", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-201556:r:Signaling by ALK", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9607240:r:FLT3 Signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9607240:r:FLT3 Signaling", "R-BTA-9013424:r:RHOV GTPase cycle", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-112399:r:IRS-mediated signalling", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013424:r:RHOV GTPase cycle", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-201556:r:Signaling by ALK", "R-RNO-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-RNO-9696273:r:RND1 GTPase cycle", "R-BTA-912631:r:Regulation of signaling by CBL", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-198203:r:PI3K/AKT activation", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-180292:r:GAB1 signalosome", "R-MMU-112399:r:IRS-mediated signalling", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-MMU-9696270:r:RND2 GTPase cycle", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR032499": {"description": "Bacteriophage CI repressor, C-terminal", "go_ids": ["GO:0051259"], "go_terms": ["GO:0051259:protein complex oligomerization:P"], "name": "Phage_CI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032500": {"description": "Spike glycoprotein S1, N-terminal domain, betacoronavirus-like", "go_ids": [], "go_terms": [], "name": "bCoV_S1_N", "pathway_ids": ["R-HSA-9679509", "R-HSA-9683686", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9694548", "R-HSA-9692916", "R-HSA-166662", "R-HSA-166663", "R-HSA-9694614", "R-HSA-9694322", "R-HSA-9694635"], "pathways": ["R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", 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"R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-RNO-9907900", "R-BTA-8948751", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-RNO-8941858", "R-RNO-5607764", "R-HSA-69017", "R-RNO-1169091", "R-BTA-9020702", "R-RNO-9766229", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-HSA-202424", "R-CEL-4641257", "R-DDI-174154", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-MMU-174154", "R-BTA-1234176", "R-MMU-69017", "R-CEL-195253", "R-DME-5658442", "R-MMU-9020702", "R-RNO-5687128", "R-RNO-382556", "R-MMU-69481", "R-BTA-350562", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-BTA-68867", "R-HSA-1234176", "R-RNO-4641258", "R-MMU-68867", "R-HSA-9931269", "R-HSA-9929491", "R-DME-209461", "R-RNO-5689880", "R-DME-75815", "R-RNO-8951664", "R-DME-69601", "R-DME-1234176", "R-HSA-1236974", "R-CEL-4608870", "R-MMU-5687128", "R-RNO-5358346", "R-DME-5358346", "R-RNO-6798695", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-DME-9907900", "R-RNO-4641257", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-MMU-532668", "R-RNO-349425", "R-MMU-9762114", "R-BTA-174184", "R-MMU-195253", "R-MMU-202424", "R-MMU-382556", "R-BTA-8939236", "R-HSA-5610780", "R-DME-209360", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-DME-432626", "R-MMU-5607761", "R-DME-8854050", "R-CEL-5689880", "R-HSA-8939902", "R-MMU-8939902", "R-DME-174178", "R-RNO-195253", "R-HSA-8939236", "R-DDI-8854050", "R-BTA-983168", "R-MMU-5607764", "R-DME-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577", "R-HSA-5676590", "R-DDI-5632684", "R-BTA-9929491", "R-HSA-4641257", "R-RNO-202424", "R-MMU-9929491", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-RNO-5607761", "R-HSA-68867", "R-DME-174154", "R-MMU-9907900", "R-CEL-4641258", "R-DDI-5658442", "R-BTA-450408", "R-HSA-8941858", "R-HSA-9755511", "R-RNO-9931269", "R-CEL-9929491", "R-DME-9755511", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-RNO-532668", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-RNO-174084", "R-HSA-8948751", "R-HSA-5689603", "R-RNO-983168", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-DME-1169091", "R-HSA-187577", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-BTA-8941858", "R-DME-4641258", "R-HSA-174184", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DME-532668", "R-DME-538864", "R-DDI-983168", "R-SCE-9907900", "R-HSA-5668541", "R-HSA-9929356", "R-CEL-69601", "R-CEL-68949", "R-DME-5632684", "R-HSA-5687128", "R-DME-432395", "R-RNO-5658442", "R-MMU-983168", "R-RNO-5610785", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9907900:r:Proteasome assembly", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CEL-5689603:r:UCH proteinases", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-4641258:r:Degradation of DVL", "R-SPO-5689603:r:UCH proteinases", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-4641258:r:Degradation of DVL", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-5689603:r:UCH proteinases", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-9907900:r:Proteasome assembly", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5689603:r:UCH proteinases", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-202424:r:Downstream TCR signaling", "R-CEL-4641257:r:Degradation of AXIN", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-8951664:r:Neddylation", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1236974:r:ER-Phagosome pathway", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-9907900:r:Proteasome assembly", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-9907900:r:Proteasome assembly", "R-RNO-4641257:r:Degradation of AXIN", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-5632684:r:Hedgehog 'on' state", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9907900:r:Proteasome assembly", "R-CEL-4641258:r:Degradation of DVL", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5689603:r:UCH proteinases", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-538864:r:Degradation of CRY", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-68949:r:Orc1 removal from chromatin", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-432395:r:Degradation of TIM", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR032502": {"description": "Domain of unknown function DUF4979", "go_ids": [], "go_terms": [], "name": "DUF4979", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032503": {"description": "FAD dependent oxidoreductase, central domain", "go_ids": [], "go_terms": [], "name": "FAO_M", "pathway_ids": ["R-MMU-204174", "R-HSA-6798163", "R-HSA-204174", "R-RNO-6798163", "R-MMU-6798163"], "pathways": ["R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-6798163:r:Choline catabolism", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-6798163:r:Choline catabolism", "R-MMU-6798163:r:Choline catabolism"], "type": "Domain"}, "IPR032504": {"description": "Domain of unknown function DUF4978", "go_ids": [], "go_terms": [], "name": "DUF4978", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032505": {"description": "Non-structural protein NSP4, C-terminal, coronavirus", "go_ids": [], "go_terms": [], "name": "CoV_NSP4_C", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR032506": {"description": "N-sulphoglucosamine sulphohydrolase, C-terminal", "go_ids": [], "go_terms": [], "name": "SGSH_C", "pathway_ids": ["R-HSA-2206307", "R-HSA-2024096"], "pathways": ["R-HSA-2206307:r:MPS IIIA - Sanfilippo syndrome A", "R-HSA-2024096:r:HS-GAG degradation"], "type": "Domain"}, "IPR032507": {"description": "BT1760, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BT1760_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032508": {"description": "Protein FecR, C-terminal", "go_ids": [], "go_terms": [], "name": "FecR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032509": {"description": "Domain of unknown function DUF4973", "go_ids": [], "go_terms": [], "name": "DUF4973", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032510": {"description": "Domain of unknown function DUF4972", "go_ids": [], "go_terms": [], "name": "DUF4972", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032511": {"description": "Domain of unknown function DUF4971", "go_ids": [], "go_terms": [], "name": "DUF4971", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032512": {"description": "Domain of unknown function DUF4969", "go_ids": [], "go_terms": [], "name": "DUF4969", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032514": {"description": "Glutaminase A, central domain", "go_ids": [], "go_terms": [], "name": "GtaA_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032515": {"description": "Domain of unknown function DUF4964", "go_ids": [], "go_terms": [], "name": "DUF4964", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032516": {"description": "Na+/H+ antiporter, budding yeast", "go_ids": ["GO:0042391", "GO:0015385", "GO:0015079", "GO:0005886", "GO:0036376", "GO:0120029"], "go_terms": ["GO:0042391:regulation of membrane potential:P", "GO:0015385:sodium:proton antiporter activity:F", "GO:0015079:potassium ion transmembrane transporter activity:F", "GO:0005886:plasma membrane:C", "GO:0036376:sodium ion export across plasma membrane:P", "GO:0120029:proton export across plasma membrane:P"], "name": "Nha1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032518": {"description": "Dermatan-sulfate epimerase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "DSE-like_N", "pathway_ids": ["R-MMU-2022923", "R-HSA-2022923"], "pathways": ["R-MMU-2022923:r:DS-GAG biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis"], "type": "Domain"}, "IPR032519": {"description": "YbgF, trimerisation domain", "go_ids": ["GO:0070206"], "go_terms": ["GO:0070206:protein trimerization:P"], "name": "YbgF_tri", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032520": {"description": "MukB, hinge domain", "go_ids": [], "go_terms": [], "name": "MukB_hinge", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032521": {"description": "Pestivirus envelope glycoprotein E2", "go_ids": [], "go_terms": [], "name": "Pestivirus_E2", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR032522": {"description": "Domain of unknown function DUF4961", "go_ids": [], "go_terms": [], "name": "DUF4961", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032523": {"description": "CcmF, C-terminal beta-sandwich", "go_ids": [], "go_terms": [], "name": "CcmF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032524": {"description": "ABC transporter Uup, C-terminal", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "ABC_tran_C", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR032525": {"description": "Peptidase family U32, C-terminal", "go_ids": [], "go_terms": [], "name": "Peptidase_U32_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032526": {"description": "Surface glycan-binding protein BT_1761, levan binding domain", "go_ids": [], "go_terms": [], "name": "BT_1761_lev", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032527": {"description": "Domain of unknown function DUF4959", "go_ids": [], "go_terms": [], "name": "DUF4959", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032528": {"description": "Sigma 54 modulation/S30EA ribosomal protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Ribosom_S30AE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032529": {"description": "Surface glycan binding protein BT4661-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BT4661-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032530": {"description": "Domain of unknown function DUF4957", "go_ids": [], "go_terms": [], "name": "DUF4957", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032531": {"description": "Protein of unknown function DUF4956", "go_ids": [], "go_terms": [], "name": "DUF4956", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032532": {"description": "Domain of unknown function DUF4955", "go_ids": [], "go_terms": [], "name": "DUF4955", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032533": {"description": "Domain of unknown function DUF4954", "go_ids": [], "go_terms": [], "name": "DUF4954", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032534": {"description": "EcxA, zinc-binding", "go_ids": [], "go_terms": [], "name": "EcxA_zinc-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032535": {"description": "Oberon, coiled-coil region", "go_ids": [], "go_terms": [], "name": "Oberon_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032536": {"description": "Transmembrane protein 100", "go_ids": [], "go_terms": [], "name": "TMEM100", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032537": {"description": "Protein of unknown function DUF4952", "go_ids": [], "go_terms": [], "name": "DUF4952", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032538": {"description": "Protein of unknown 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{"description": "Protein of unknown function DUF4945", "go_ids": [], "go_terms": [], "name": "DUF4945", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032545": {"description": "Protein of unknown function DUF4944", "go_ids": [], "go_terms": [], "name": "DUF4944", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032546": {"description": "Protein of unknown function DUF4943", "go_ids": [], "go_terms": [], "name": "DUF4943", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032547": {"description": "Protein of unknown function DUF4941", "go_ids": [], "go_terms": [], "name": "DUF4941", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032548": {"description": "Protein of unknown function DUF4940", "go_ids": [], "go_terms": [], "name": "DUF4940", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032549": {"description": "RTL1/3-8/LDOC, capsid-like domain", "go_ids": [], "go_terms": [], "name": "RTL1/1-8/LDOC_capsid-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032550": {"description": "PBP-dependent ABC transporters TM subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "TM_PBP2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032551": {"description": "HTH-type transcriptional repressor, C-terminal", "go_ids": [], "go_terms": [], "name": "BscR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032552": {"description": "Acin1, RNSP1-SAP18 binding (RSB) motif", "go_ids": [], "go_terms": [], "name": "RSB_motif", "pathway_ids": ["R-MMU-111465", "R-HSA-72163", "R-MMU-72163", "R-HSA-111465"], "pathways": ["R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Conserved_site"}, "IPR032553": {"description": "UCP032676, C2H2 type zinc-finger domain", "go_ids": [], "go_terms": [], "name": "UCP032676_Znf-C2H2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032554": {"description": "Protein of unknown function DUF4938", "go_ids": [], "go_terms": [], "name": "DUF4938", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032555": {"description": "Domain of unknown function DUF4937", "go_ids": [], "go_terms": [], "name": "DUF4937", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032556": {"description": "Protein of unknown function DUF4936", "go_ids": [], "go_terms": [], "name": "DUF4936", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032557": {"description": "PIN domain (DUF4935)", "go_ids": [], "go_terms": [], "name": "DUF4935", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032558": {"description": "Domain of unknown function DUF4934", "go_ids": [], "go_terms": [], "name": "DUF4934", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032559": {"description": "Protein of unknown function DUF4933", "go_ids": [], "go_terms": [], "name": "DUF4933", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032560": {"description": "Protein of unknown function DUF4932", "go_ids": [], "go_terms": [], "name": "DUF4932", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032561": {"description": "Protein of unknown function DUF4930", "go_ids": [], "go_terms": [], "name": "DUF4930", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032562": {"description": "Domain of unknown function DUF4929", "go_ids": [], "go_terms": [], "name": "DUF4929", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032563": {"description": "DAMP1, SANT/Myb-like domain", "go_ids": [], "go_terms": [], "name": "DAMP1_SANT-like", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR032564": {"description": "Protein of unknown function DUF4928", "go_ids": [], "go_terms": [], "name": "DUF4928", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032565": {"description": "Nuclear receptor coactivator 2/3, DUF4927", "go_ids": [], "go_terms": [], "name": "NCOA2/3_DUF4927", "pathway_ids": ["R-HSA-1989781", "R-RNO-193807", "R-DRE-211976", "R-DRE-193807", "R-HSA-2151201", "R-DRE-192105", "R-DRE-193368", "R-HSA-193368", "R-RNO-5687128", "R-DRE-400206", "R-RNO-9018519", "R-HSA-1368108", "R-HSA-5625886", "R-HSA-9841922", "R-RNO-192105", "R-RNO-159418", "R-RNO-5625886", "R-HSA-9933387", "R-HSA-9707564", "R-MMU-5625886", "R-MMU-400206", "R-DRE-3214847", "R-HSA-9018519", "R-HSA-9931509", "R-HSA-2426168", "R-MMU-3214847", "R-HSA-5617472", "R-RNO-400206", "R-MMU-193368", "R-DRE-5625886", "R-MMU-192105", "R-HSA-381340", "R-HSA-9707616", "R-HSA-192105", "R-RNO-9707564", "R-HSA-193807", "R-MMU-9018519", "R-DRE-159418", "R-RNO-3214847", "R-HSA-5687128", "R-MMU-211976", "R-RNO-211976", "R-RNO-193368", "R-HSA-400206", "R-RNO-9841922", "R-HSA-3214847", "R-HSA-159418", "R-DRE-9707564", "R-MMU-5687128", "R-HSA-3899300", "R-HSA-211976", "R-MMU-159418", "R-MMU-9707564", "R-MMU-193807"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DRE-211976:r:Endogenous sterols", "R-DRE-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DRE-192105:r:Synthesis of bile acids and bile salts", "R-DRE-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DRE-3214847:r:HATs acetylate histones", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DRE-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DRE-159418:r:Recycling of bile acids and salts", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-211976:r:Endogenous sterols", "R-RNO-211976:r:Endogenous sterols", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-159418:r:Recycling of bile acids and salts", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-211976:r:Endogenous sterols", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "type": "Domain"}, "IPR032566": {"description": "Aprataxin, C2HE/C2H2/C2HC zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-C2HE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032567": {"description": "RTL1-related", "go_ids": [], "go_terms": [], "name": "RTL1-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032568": {"description": "Protein of unknown function DUF4926", "go_ids": [], "go_terms": [], "name": "DUF4926", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032569": {"description": "Nucleophosmin, C-terminal", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "NPM1_C", "pathway_ids": ["R-HSA-606279", "R-HSA-6804115", "R-HSA-9700645", "R-HSA-9833482", "R-MMU-3899300", "R-RNO-606279", "R-MMU-606279", "R-MMU-8869496", "R-RNO-6804115", "R-MMU-9833482", "R-HSA-9725371", "R-HSA-8869496", "R-RNO-8869496", "R-MMU-6804115", "R-HSA-3899300", "R-HSA-180746", "R-HSA-9692914", "R-HSA-9725370", "R-RNO-9833482", "R-RNO-3899300"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-180746:r:Nuclear import of Rev protein", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-3899300:r:SUMOylation of transcription cofactors"], "type": "Domain"}, "IPR032570": {"description": "Splicing factor 1, helix-hairpin domain", "go_ids": [], "go_terms": [], "name": "SF1-HH", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR032571": {"description": "KHDRBS, Qua1 domain", "go_ids": [], "go_terms": [], "name": "Qua1_dom", "pathway_ids": ["R-XTR-8849468", "R-DRE-8849468", "R-MMU-8849468", "R-RNO-8849468", "R-HSA-8849468"], "pathways": ["R-XTR-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-DRE-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing"], "type": "Domain"}, "IPR032572": {"description": "Nuclear migration protein nudC", "go_ids": [], "go_terms": [], "name": "NuDC", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-BTA-9696270", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-9696270", "R-RNO-2500257", "R-RNO-9696270", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-BTA-5663220", "R-MMU-68877", "R-HSA-9648025", "R-RNO-5663220", "R-BTA-2467813", "R-HSA-68877", "R-BTA-2500257", "R-RNO-9648025", "R-MMU-9696270", "R-RNO-2467813", "R-HSA-5663220", "R-BTA-9648025", "R-BTA-141444", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-BTA-9696270:r:RND2 GTPase cycle", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-68877:r:Mitotic Prometaphase", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Domain"}, "IPR032573": {"description": "Protein of unknown function DUF4925", "go_ids": [], "go_terms": [], "name": "DUF4925", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032574": {"description": "Protein of unknown function DUF4924", "go_ids": [], "go_terms": [], "name": "DUF4924", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032575": {"description": "Lipocalin-like domain (DUF4923)", "go_ids": [], "go_terms": [], "name": "DUF4923", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032576": {"description": "Domain of unknown function DUF4921", "go_ids": [], "go_terms": [], "name": "DUF4921", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032577": {"description": "Protein of unknown function DUF4920", "go_ids": [], "go_terms": [], "name": "DUF4920", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032578": {"description": "Protein of unknown function DUF4919", "go_ids": [], "go_terms": [], "name": "DUF4919", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032580": {"description": "SatD family", "go_ids": [], "go_terms": [], "name": "SatD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032581": {"description": "Protein of unknown function DUF4917", "go_ids": [], "go_terms": [], "name": "DUF4917", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032582": {"description": "Protein of unknown function DUF4916", "go_ids": [], "go_terms": [], "name": "DUF4916", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032583": {"description": "Protein of unknown function DUF4914", "go_ids": [], "go_terms": [], "name": "DUF4914", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032584": {"description": "Protein of unknown function DUF4913", "go_ids": [], "go_terms": [], "name": "DUF4913", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032585": {"description": "Domain of unknown function DUF4912", "go_ids": [], "go_terms": [], "name": "DUF4912", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032586": {"description": "Tagaturonate/fructuronate epimerase", "go_ids": ["GO:0016853"], "go_terms": ["GO:0016853:isomerase activity:F"], "name": "UxaE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032587": {"description": "Protein of unknown function DUF4911", "go_ids": [], "go_terms": [], "name": "DUF4911", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032588": {"description": "Putative GDSL-like Lipase/Acylhydrolase", "go_ids": [], "go_terms": [], "name": "Lipase_GDSL_lke", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032589": {"description": "Domain of unknown function DUF4910", "go_ids": [], "go_terms": [], "name": "DUF4910", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032590": {"description": "Protein of unknown function DUF4909", "go_ids": [], "go_terms": [], "name": "DUF4909", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032591": {"description": "Protein of unknown function DUF4908", "go_ids": [], "go_terms": [], "name": "DUF4908", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032592": {"description": "Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirus", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "NSP3_NAB_bCoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR032593": {"description": "Protein of unknown function DUF4907", "go_ids": [], "go_terms": [], "name": "DUF4907", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032594": {"description": "Domain of unknown function DUF4906", "go_ids": [], "go_terms": [], "name": "DUF4906", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032595": {"description": "Protein of unknown function DUF4905", "go_ids": [], "go_terms": [], "name": "DUF4905", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032596": {"description": "Domain of unknown function DUF4904", "go_ids": [], "go_terms": [], "name": "DUF4904", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032597": {"description": "Protein of unknown function DUF4903", "go_ids": [], "go_terms": [], "name": "DUF4903", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032598": {"description": "Transcriptional regulator RsaM-like", "go_ids": [], "go_terms": [], "name": "RsaM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032599": {"description": "YcdB/YcdC, repeated domain", "go_ids": [], "go_terms": [], "name": "YcdB/YcdC_rep_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032600": {"description": "Sm-like domain", "go_ids": [], "go_terms": [], "name": "Sm-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032601": {"description": "Protein of unknown function DUF4900", "go_ids": [], "go_terms": [], "name": "DUF4900", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032602": {"description": "Protein of unknown function DUF4899", "go_ids": [], "go_terms": [], "name": "DUF4899", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032603": {"description": "Protein of unknown function DUF4898", "go_ids": [], "go_terms": [], "name": "DUF4898", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032604": {"description": "Protein of unknown function DUF4897", "go_ids": [], "go_terms": [], "name": "DUF4897", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032605": {"description": "Domain of unknown function DUF4896", "go_ids": [], "go_terms": [], "name": "DUF4896", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032606": {"description": "Protein of unknown function DUF4895", "go_ids": [], "go_terms": [], "name": "DUF4895", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032607": {"description": "Protein of unknown function DUF4894", "go_ids": [], "go_terms": [], "name": "DUF4894", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032608": {"description": "Protein of unknown function DUF4892", "go_ids": [], "go_terms": [], "name": "DUF4892", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032609": {"description": "Protein of unknown function DUF4893", "go_ids": [], "go_terms": [], "name": "DUF4893", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032610": {"description": "Domain of unknown function DUF2172", "go_ids": [], "go_terms": [], "name": "DUF2172", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032611": {"description": "Protein of unknown function DUF4891", "go_ids": [], "go_terms": [], "name": "DUF4891", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032612": {"description": "Protein of unknown function DUF4890", "go_ids": [], "go_terms": [], "name": "DUF4890", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032613": {"description": "Protein of unknown function DUF4889", "go_ids": [], "go_terms": [], "name": "DUF4889", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032614": {"description": "Protein of unknown function DUF4888", "go_ids": [], "go_terms": [], "name": "DUF4888", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032615": {"description": "Protein of unknown function DUF4887", "go_ids": [], "go_terms": [], "name": "DUF4887", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032616": {"description": "Domain of unknown function DUF4886", "go_ids": [], "go_terms": [], "name": "DUF4886", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032617": {"description": "Protein of unknown function DUF4885", "go_ids": [], "go_terms": [], "name": "DUF4885", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032618": {"description": "Protein of unknown function DUF4884", "go_ids": [], "go_terms": [], "name": "DUF4884", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032619": {"description": "Protein of unknown function DUF4883", "go_ids": [], "go_terms": [], "name": "DUF4883", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032620": {"description": "Protein of unknown function DUF4882", "go_ids": [], "go_terms": [], "name": "DUF4882", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032621": {"description": "Protein of unknown function DUF4881", "go_ids": [], "go_terms": [], "name": "DUF4881", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032622": {"description": "UCP01524, winged helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "UCP01524_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032623": {"description": "FecR, N-terminal", "go_ids": [], "go_terms": [], "name": "FecR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032624": {"description": "Protein of unknown function DUF4879", "go_ids": [], "go_terms": [], "name": "DUF4879", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032625": {"description": "Peptidase M64, N-terminal", "go_ids": [], "go_terms": [], "name": "M64_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032626": {"description": "GxGYxYP putative glycoside hydrolase, first N-terminal domain", "go_ids": [], "go_terms": [], "name": "GxGYxYP_N_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032627": {"description": "Protein of unknown function DUF4876", "go_ids": [], "go_terms": [], "name": "DUF4876", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032628": {"description": "Adenylate cyclase, N-terminal", "go_ids": [], "go_terms": [], "name": "AC_N", "pathway_ids": ["R-HSA-9634597", "R-RNO-418597", "R-HSA-381753", "R-DME-170670", "R-MMU-418597", "R-BTA-163615", "R-RNO-5610787", "R-RNO-400042", "R-HSA-163615", "R-HSA-432040", "R-DME-170660", "R-HSA-5610787", "R-HSA-442720", "R-MMU-5610787", "R-HSA-170660", "R-DME-163615", "R-MMU-163615", "R-DME-5610787", "R-MMU-400042", "R-HSA-163359", "R-HSA-9660821", "R-DME-418597", "R-RNO-170660", "R-HSA-418555", "R-HSA-400042", "R-BTA-418597", "R-BTA-170670", "R-RNO-163615", "R-HSA-418594", "R-HSA-381676", "R-MMU-170660", "R-HSA-164378", "R-HSA-418597", "R-BTA-170660", "R-HSA-170670", "R-MMU-170670", "R-HSA-9856530", "R-BTA-5610787", "R-HSA-9664323", "R-RNO-170670"], "pathways": ["R-HSA-9634597:r:GPER1 signaling", "R-RNO-418597:r:G alpha (z) signalling events", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-DME-170670:r:Adenylate cyclase inhibitory pathway", "R-MMU-418597:r:G alpha (z) signalling events", "R-BTA-163615:r:PKA activation", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-163615:r:PKA activation", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-170660:r:Adenylate cyclase activating pathway", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-170660:r:Adenylate cyclase activating pathway", "R-DME-163615:r:PKA activation", "R-MMU-163615:r:PKA activation", "R-DME-5610787:r:Hedgehog 'off' state", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-DME-418597:r:G alpha (z) signalling events", "R-RNO-170660:r:Adenylate cyclase activating pathway", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-BTA-418597:r:G alpha (z) signalling events", "R-BTA-170670:r:Adenylate cyclase inhibitory pathway", "R-RNO-163615:r:PKA activation", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-170660:r:Adenylate cyclase activating pathway", "R-HSA-164378:r:PKA activation in glucagon signalling", "R-HSA-418597:r:G alpha (z) signalling events", "R-BTA-170660:r:Adenylate cyclase activating pathway", "R-HSA-170670:r:Adenylate cyclase inhibitory pathway", "R-MMU-170670:r:Adenylate cyclase inhibitory pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-170670:r:Adenylate cyclase inhibitory pathway"], "type": "Domain"}, "IPR032629": {"description": "Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain", "go_ids": [], "go_terms": [], "name": "DCB_dom", "pathway_ids": ["R-HSA-390471"], "pathways": ["R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis"], "type": "Domain"}, "IPR032630": {"description": "P-type ATPase, C-terminal", "go_ids": [], "go_terms": [], "name": "P_typ_ATPase_c", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-DRE-936837", "R-XTR-936837", "R-CEL-6798695", "R-SCE-6798695", "R-SPO-936837", "R-HSA-936837", "R-BTA-936837", "R-RNO-936837", "R-SCE-936837", "R-PFA-6798695", "R-MMU-6798695", "R-MMU-936837", "R-CEL-936837", "R-PFA-936837"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-936837:r:Ion transport by P-type ATPases", "R-XTR-936837:r:Ion transport by P-type ATPases", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases", "R-PFA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-PFA-936837:r:Ion transport by P-type ATPases"], "type": "Domain"}, "IPR032631": {"description": "P-type ATPase, N-terminal", "go_ids": [], "go_terms": [], "name": "P-type_ATPase_N", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-DRE-936837", "R-XTR-936837", "R-CEL-6798695", "R-SCE-6798695", "R-SPO-936837", "R-HSA-936837", "R-BTA-936837", "R-RNO-936837", "R-SCE-936837", "R-MMU-6798695", "R-MMU-936837", "R-CEL-936837"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-936837:r:Ion transport by P-type ATPases", "R-XTR-936837:r:Ion transport by P-type ATPases", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CEL-936837:r:Ion transport by P-type ATPases"], "type": "Domain"}, "IPR032632": {"description": "Peptidase M16, middle/third domain", "go_ids": [], "go_terms": [], "name": "Peptidase_M16_M", "pathway_ids": ["R-BTA-9033241", "R-MMU-5689880", "R-RNO-9033241", "R-SPO-9033241", "R-RNO-77387", "R-MMU-77387", "R-BTA-5689880", "R-HSA-5689880", "R-HSA-77387", "R-DME-9033241", "R-SCE-9033241", "R-MMU-9033241", "R-BTA-77387", "R-DDI-9033241", "R-HSA-9033241", "R-DME-5689880", "R-RNO-5689880"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-9033241:r:Peroxisomal protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-RNO-77387:r:Insulin receptor recycling", "R-MMU-77387:r:Insulin receptor recycling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-77387:r:Insulin receptor recycling", "R-DME-9033241:r:Peroxisomal protein import", "R-SCE-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-BTA-77387:r:Insulin receptor recycling", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-5689880:r:Ub-specific processing proteases", "R-RNO-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR032633": {"description": "ThiJ/PfpI family-like", "go_ids": [], "go_terms": [], "name": "ThiJ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032634": {"description": "Gef2/Nod1 domain", "go_ids": [], "go_terms": [], "name": "Gef2/Nod1_dom", "pathway_ids": ["R-SPO-416482", "R-SPO-9013148"], "pathways": ["R-SPO-416482:r:G alpha (12/13) signalling events", "R-SPO-9013148:r:CDC42 GTPase cycle"], "type": "Domain"}, "IPR032635": {"description": "Surface antigen domain", "go_ids": [], "go_terms": [], "name": "Anti_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032636": {"description": "Pilus assembly protein, E-set like domain", "go_ids": [], "go_terms": [], "name": "Pilus_assem_E-set-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032637": {"description": "Putative phage holin-like", "go_ids": [], "go_terms": [], "name": "Phage_holin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032638": {"description": "Putative bacterial porin", "go_ids": [], "go_terms": [], "name": "Porin_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032639": {"description": "Tex protein, YqgF-like domain", "go_ids": [], "go_terms": [], "name": "Tex_YqgF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032640": {"description": "AMP-activated protein kinase, glycogen-binding domain", "go_ids": [], "go_terms": [], "name": "AMPK1_CBM", "pathway_ids": ["R-RNO-163680", "R-HSA-5628897", "R-BTA-380972", "R-RNO-1632852", "R-BTA-6804756", "R-SPO-200425", "R-RNO-200425", "R-MMU-5628897", "R-SPO-163680", "R-RNO-6804756", "R-HSA-9613354", "R-SCE-200425", "R-SCE-163680", "R-HSA-380972", "R-MMU-163680", "R-HSA-9931269", "R-BTA-9931269", "R-SPO-5628897", "R-MMU-200425", "R-SPO-380972", "R-RNO-5628897", "R-RNO-9931269", "R-HSA-2151209", "R-BTA-1632852", "R-BTA-5628897", "R-SCE-1632852", "R-HSA-6804756", "R-HSA-200425", "R-SCE-380972", "R-HSA-1445148", "R-RNO-380972", "R-MMU-9931269", "R-HSA-1632852", "R-SPO-1632852", "R-HSA-163680", "R-HSA-9619483", "R-MMU-380972", "R-MMU-1632852", "R-MMU-6804756"], "pathways": ["R-RNO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-1632852:r:Macroautophagy", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9613354:r:Lipophagy", "R-SCE-200425:r:Carnitine shuttle", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-200425:r:Carnitine shuttle", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-BTA-1632852:r:Macroautophagy", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-1632852:r:Macroautophagy", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-200425:r:Carnitine shuttle", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation"], "type": "Domain"}, "IPR032672": {"description": "TmcA/NAT10/Kre33", "go_ids": ["GO:0008080"], "go_terms": ["GO:0008080:N-acetyltransferase activity:F"], "name": "TmcA/NAT10/Kre33", "pathway_ids": ["R-HSA-6790901"], "pathways": ["R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR032674": {"description": "LRR-containing bacterial E3 ligase, N-terminal", "go_ids": [], "go_terms": [], "name": "LRR_E3_ligase_N", "pathway_ids": ["PWY-7511", "R-HSA-9956593"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense"], "type": "Domain"}, "IPR032675": {"description": "Leucine-rich repeat domain superfamily", "go_ids": [], "go_terms": [], "name": "LRR_dom_sf", "pathway_ids": ["R-RNO-2022923", "R-HSA-174178", "R-MMU-9770562", "R-HSA-8936459", "R-SPO-5223345", "R-HSA-9010553", "R-HSA-8951664", "R-HSA-6799198", "R-HSA-198745", "R-HSA-69231", "R-MMU-5689880", "R-HSA-9662360", "R-CEL-9770562", "R-RNO-177504", "R-HSA-937041", "R-DME-214842", "R-HSA-9956593", "R-HSA-9708530", "R-RNO-5686938", "R-HSA-3270619", "R-MMU-170968", "R-HSA-2022870", "R-MMU-380259", "R-BTA-168142", "R-MMU-163210", "R-MMU-3134975", "R-DDI-5673001", "R-HSA-373752", "R-RNO-936964", "R-XTR-380320", "R-XTR-4641263", "R-HSA-3656244", "R-HSA-72163", "R-DME-9010553", "R-CFA-983168", "R-HSA-9609736", 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"R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-BTA-917937", "R-RNO-9696264", "R-MMU-2024101", "R-HSA-9820841", "R-BTA-163210", "R-HSA-9013026", "R-HSA-8857538", "R-HSA-1839117", "R-HSA-2467813", "R-HSA-168928", "R-HSA-9845620", "R-MMU-430116", "R-MMU-8980692", "R-HSA-9824878", "R-HSA-9013106", "R-CEL-983168", "R-MMU-388844", "R-HSA-159227", "R-HSA-9013423", "R-GGA-451514", "R-DRE-2022857", "R-CEL-9010553", "R-MMU-917937", "R-DRE-9696264", "R-RNO-445355", "R-CEL-2243919", "R-MMU-6803207", "R-RNO-9707616", "R-DDI-1632852", "R-MMU-977606", "R-MMU-109704", "R-MMU-9028731", "R-DDI-392517", "R-HSA-376176", "R-HSA-5602566", "R-HSA-380270", "R-HSA-9665250", "R-DRE-844456"], "pathways": ["R-RNO-2022923:r:DS-GAG biosynthesis", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-5223345:r:Miscellaneous transport and binding events", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-8951664:r:Neddylation", "R-HSA-6799198:r:Complex I biogenesis", "R-HSA-198745:r:Signalling to STAT3", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CEL-9770562:r:mRNA Polyadenylation", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-168142:r:Toll Like Receptor 10 (TLR10) Cascade", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-373752:r:Netrin-1 signaling", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-2022870:r:CS-GAG biosynthesis", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-844455:r:The NLRP1 inflammasome", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-5689880:r:Ub-specific processing proteases", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-CEL-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-444821:r:Relaxin receptors", "R-MMU-418555:r:G alpha (s) signalling events", "R-CEL-8951664:r:Neddylation", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-DDI-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-BTA-5682910:r:LGI-ADAM interactions", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-166020:r:Transfer of LPS from LBP carrier to CD14", "R-DDI-8951664:r:Neddylation", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-MMU-8951664:r:Neddylation", "R-RNO-198203:r:PI3K/AKT activation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-8949613:r:Cristae formation", "R-MMU-187042:r:TRKA activation by NGF", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DME-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-DDI-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-MMU-6799198:r:Complex I biogenesis", "R-GGA-1461957:r:Beta defensins", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-CFA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-844456:r:The NLRP3 inflammasome", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-SSC-375281:r:Hormone ligand-binding receptors", "R-HSA-8949613:r:Cristae formation", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-375281:r:Hormone ligand-binding receptors", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-5223345:r:Miscellaneous transport and binding events", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-CFA-2022923:r:DS-GAG biosynthesis", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-844456:r:The NLRP3 inflammasome", "R-CEL-209968:r:Thyroxine biosynthesis", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-198203:r:PI3K/AKT activation", "R-RNO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-2024101:r:CS/DS degradation", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-216083:r:Integrin cell surface interactions", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-DRE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-354192:r:Integrin signaling", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-MMU-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-187042:r:TRKA activation by NGF", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-DRE-8951664:r:Neddylation", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-GGA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-1461957:r:Beta defensins", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-DRE-5689901:r:Metalloprotease DUBs", "R-DDI-193648:r:NRAGE signals death through JNK", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-1461957:r:Beta defensins", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-CEL-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-GGA-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-5689901:r:Metalloprotease DUBs", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-HSA-168188:r:Toll Like Receptor TLR6:TLR2 Cascade", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-MMU-444821:r:Relaxin receptors", "R-RNO-166166:r:MyD88-independent TLR4 cascade", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-168181:r:Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CFA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-444821:r:Relaxin receptors", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-9830674:r:Formation of the ureteric bud", "R-BTA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DME-5223345:r:Miscellaneous transport and binding events", "R-RNO-8873719:r:RAB geranylgeranylation", "R-CFA-1679131:r:Trafficking and processing of endosomal TLR", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-RNO-390522:r:Striated Muscle Contraction", "R-DDI-3295583:r:TRP channels", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-MMU-375281:r:Hormone ligand-binding receptors", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-390522:r:Striated Muscle Contraction", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-MMU-177929:r:Signaling by EGFR", "R-HSA-9020702:r:Interleukin-1 signaling", "R-SSC-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-HSA-167021:r:PLC-gamma1 signalling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-CEL-5673000:r:RAF activation", "R-CFA-375281:r:Hormone ligand-binding receptors", "R-MMU-445355:r:Smooth Muscle Contraction", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DRE-2022854:r:Keratan sulfate biosynthesis", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-RNO-8951664:r:Neddylation", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-HSA-1236974:r:ER-Phagosome pathway", "R-RNO-8949613:r:Cristae formation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-SCE-917937:r:Iron uptake and transport", "R-HSA-68949:r:Orc1 removal from chromatin", "R-DDI-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-MMU-68949:r:Orc1 removal from chromatin", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-9824856:r:Defective regulation of TLR7 by endogenous ligand", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-3214842:r:HDMs demethylate histones", "R-MMU-8873719:r:RAB geranylgeranylation", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-877300:r:Interferon gamma signaling", "R-CFA-444821:r:Relaxin receptors", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-5682910:r:LGI-ADAM interactions", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-5223345:r:Miscellaneous transport and binding events", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-844455:r:The NLRP1 inflammasome", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-RNO-375281:r:Hormone ligand-binding receptors", "R-MMU-390522:r:Striated Muscle Contraction", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-BTA-390522:r:Striated Muscle Contraction", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9673221:r:Defective F9 activation", "R-HSA-9620244:r:Long-term potentiation", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-MMU-9793242:r:SUMOylation of nuclear envelope proteins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-BTA-8951664:r:Neddylation", "R-HSA-8873719:r:RAB geranylgeranylation", "R-RNO-9696270:r:RND2 GTPase cycle", "R-DME-159236:r:Transport of Mature mRNA derived from an 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"R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-844456:r:The NLRP3 inflammasome", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-2022857:r:Keratan sulfate degradation", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-6799198:r:Complex I biogenesis", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-187042:r:TRKA activation by NGF", "R-SSC-109704:r:PI3K Cascade", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9707616:r:Heme signaling", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-HSA-170984:r:ARMS-mediated activation", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-5682910:r:LGI-ADAM interactions", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-GGA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-5673000:r:RAF activation", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-2022857:r:Keratan sulfate degradation", "R-DRE-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-438066:r:Unblocking of 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Derived from an Intronless Transcript", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-BTA-216083:r:Integrin cell surface interactions", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-8873719:r:RAB geranylgeranylation", "R-CFA-8951664:r:Neddylation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-5689901:r:Metalloprotease DUBs", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DDI-170968:r:Frs2-mediated activation", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-RNO-170968:r:Frs2-mediated activation", "R-CFA-2024101:r:CS/DS degradation", "R-RNO-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-RNO-3000178:r:ECM proteoglycans", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-141444:r:Amplification of signal from 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"R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-3000178:r:ECM proteoglycans", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-GGA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5602410:r:TLR3 deficiency - HSE", "R-DME-9013406:r:RHOQ GTPase cycle", "R-MMU-168181:r:Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-BTA-2024101:r:CS/DS degradation", "R-RNO-166020:r:Transfer of LPS from LBP carrier to CD14", "R-MMU-8949613:r:Cristae formation", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1227986:r:Signaling by ERBB2", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CFA-109704:r:PI3K Cascade", "R-SCE-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9793242:r:SUMOylation of nuclear envelope proteins", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9793242:r:SUMOylation of nuclear envelope proteins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-1169092:r:Activation of RAS in B cells", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-HSA-844623:r:The IPAF inflammasome", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-5689901:r:Metalloprotease DUBs", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-5673000:r:RAF activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-DDI-5673000:r:RAF activation", "R-GGA-517856:r:TLR2 subfamily cascade", "R-HSA-5602415:r:UNC93B1 deficiency - HSE", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-844455:r:The NLRP1 inflammasome", "R-BTA-5689901:r:Metalloprotease DUBs", "R-RNO-5673000:r:RAF activation", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-2562578:r:TRIF-mediated programmed cell death", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-5223345:r:Miscellaneous transport and binding events", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-917937:r:Iron uptake and transport", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-GGA-451514:r:MyD88:TIRAP-dependent cascade initiated on plasma membrane", "R-DRE-2022857:r:Keratan sulfate degradation", "R-CEL-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-917937:r:Iron uptake and transport", "R-DRE-9696264:r:RND3 GTPase cycle", "R-RNO-445355:r:Smooth Muscle Contraction", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-9707616:r:Heme signaling", "R-DDI-1632852:r:Macroautophagy", "R-MMU-977606:r:Regulation of Complement cascade", "R-MMU-109704:r:PI3K Cascade", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DDI-392517:r:Rap1 signalling", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-5602566:r:TICAM1 deficiency - HSE", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-DRE-844456:r:The NLRP3 inflammasome"], "type": "Homologous_superfamily"}, "IPR032676": {"description": "Putative L,D-transpeptidase tautomerase", "go_ids": [], "go_terms": [], "name": "YkuD_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032677": {"description": "GTP cyclohydrolase II", "go_ids": [], "go_terms": [], "name": "GTP_cyclohydro_II", "pathway_ids": ["PWY-7539", "PWY-6168", "PWY-7991"], "pathways": ["PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-7991:t:toxoflavin biosynthesis"], "type": "Domain"}, "IPR032678": {"description": "tRNA synthetases class I, catalytic domain", "go_ids": [], "go_terms": [], "name": "tRNA-synt_1_cat_dom", "pathway_ids": ["R-HSA-9725370", "R-HSA-379716", "R-MTU-879299", "R-HSA-379726"], "pathways": ["R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-MTU-879299:r:Mycothiol biosynthesis", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Domain"}, "IPR032679": {"description": "Sin1, N-terminal", "go_ids": [], "go_terms": [], "name": "Sin1_N", "pathway_ids": ["R-MMU-9856530", "R-SPO-6804757", "R-MMU-5218920", "R-HSA-5674400", "R-RNO-1257604", "R-MMU-6804757", "R-SPO-389357", "R-GGA-6804757", "R-SPO-5218920", "R-GGA-1257604", "R-MMU-1257604", "R-CEL-6804757", "R-GGA-389357", "R-RNO-5218920", "R-DME-5218920", "R-RNO-9856530", "R-MMU-389357", "R-RNO-6804757", "R-HSA-5218920", "R-CEL-1257604", "R-CEL-389357", "R-DME-9856530", "R-HSA-6804757", "R-DME-1257604", "R-GGA-9856530", "R-HSA-389357", "R-HSA-9920951", "R-HSA-9856530", "R-CEL-9856530", "R-HSA-1257604", "R-SPO-1257604", "R-GGA-5218920", "R-DME-389357", "R-SPO-9856530", "R-CEL-5218920", "R-RNO-389357"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-GGA-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-GGA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-GGA-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling"], "type": "Domain"}, "IPR032680": {"description": "SUN domain-containing protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "SUN1_N", "pathway_ids": ["R-HSA-1221632"], "pathways": ["R-HSA-1221632:r:Meiotic synapsis"], "type": "Domain"}, "IPR032682": {"description": "Condensin complex subunit 1, C-terminal", "go_ids": [], "go_terms": [], "name": "Cnd1_C", "pathway_ids": ["R-CEL-2299718", "R-HSA-2514853", "R-HSA-2299718", "R-SCE-2514853", "R-SPO-2514853", "R-MMU-2299718", "R-MMU-2514853"], "pathways": ["R-CEL-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes"], "type": "Domain"}, "IPR032683": {"description": "Malate dehydrogenase enzyme, N-terminal", "go_ids": [], "go_terms": [], "name": "Malate_DH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032686": {"description": "2-oxoacid:ferredoxin oxidoreductase subunit beta, C-terminal", "go_ids": [], "go_terms": [], "name": "PFO_beta_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032687": {"description": "HTH-type transcriptional regulator AraC-type, N-terminal", "go_ids": [], "go_terms": [], "name": "AraC-type_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032688": {"description": "ABC-2 type transporter permease protein NosY-like", "go_ids": ["GO:0140359", "GO:0055085"], "go_terms": ["GO:0140359:ABC-type transporter activity:F", "GO:0055085:transmembrane transport:P"], "name": "ABC2_NosY-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032689": {"description": "TraD/TraG, TraM 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"R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-199992:r:trans-Golgi Network Vesicle Budding", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR032692": {"description": "Integral membrane protein YccS, N-terminal", "go_ids": [], "go_terms": [], "name": "YccS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032693": {"description": "YtkA-like domain", "go_ids": [], "go_terms": [], "name": "YtkA-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032694": {"description": "Copper transport protein C/D", "go_ids": ["GO:0006825"], "go_terms": ["GO:0006825:copper ion transport:P"], "name": "CopC/D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032695": {"description": "Integrin domain 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"R-HSA-9013423", "R-RNO-8874081", "R-HSA-114608", "R-MMU-8874081", "R-RNO-445355", "R-RNO-354192", "R-CEL-354192", "R-RNO-5674135", "R-BTA-2129379", "R-RNO-2173789", "R-CEL-9013423", "R-BTA-8874081", "R-MMU-2173789", "R-MMU-3000157", "R-DME-202733", "R-HSA-3000170", "R-HSA-2129379", "R-MMU-1566977", "R-DME-6798695", "R-DME-446107", "R-MMU-354194", "R-MMU-1236973", "R-RNO-9013423", "R-CEL-445355", "R-HSA-5663220", "R-MMU-9013149", "R-BTA-216083", "R-RNO-3000170", "R-HSA-202733", "R-HSA-9927426", "R-HSA-6798695", "R-HSA-5674135", "R-HSA-166016", "R-DME-198933", "R-CEL-354194", "R-CEL-6798695", "R-BTA-6798695", "R-RNO-3000157", "R-RNO-9013149", "R-MMU-4420097", "R-MMU-9013404", "R-HSA-9927418", "R-BTA-2173789", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-HSA-446343", "R-CEL-202733", "R-RNO-202733", "R-HSA-9926550", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-3000178", "R-HSA-2173789", "R-CEL-216083", "R-BTA-198933", "R-CEL-9860927", "R-RNO-198933", "R-CEL-1236973", 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MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-216083:r:Integrin cell surface interactions", "R-RNO-3000170:r:Syndecan interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000157:r:Laminin interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-1566948:r:Elastic fibre formation", "R-DME-354192:r:Integrin signaling", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-CEL-1566977:r:Fibronectin matrix formation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-1566948:r:Elastic fibre formation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-354192:r:Integrin signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-210991:r:Basigin interactions", "R-BTA-1566977:r:Fibronectin matrix formation", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9830674:r:Formation of the ureteric bud", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Homologous_superfamily"}, "IPR032696": {"description": "Squalene cyclase, C-terminal", "go_ids": [], "go_terms": [], "name": "SQ_cyclase_C", "pathway_ids": ["R-SCE-9969896", "R-DDI-9969896", "R-MMU-9969896", "R-RNO-9969896", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["R-SCE-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR032697": {"description": "Squalene cyclase, N-terminal", "go_ids": [], "go_terms": [], "name": "SQ_cyclase_N", "pathway_ids": ["R-SCE-9969896", "R-DDI-9969896", "R-MMU-9969896", "R-RNO-9969896", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["R-SCE-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR032698": {"description": "Protein SirB1, N-terminal", "go_ids": [], "go_terms": [], "name": "SirB1_N", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR032699": {"description": "Izumo protein, immunoglobulin domain", "go_ids": [], "go_terms": [], "name": "Izumo-Ig", "pathway_ids": ["R-MMU-1300645", "R-RNO-1300645", "R-HSA-1300645", "R-DRE-1300645"], "pathways": ["R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-DRE-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding"], "type": "Domain"}, "IPR032700": {"description": "Izumo sperm-egg fusion protein 1", "go_ids": ["GO:0007342", "GO:0016020", "GO:0035036", "GO:0005102"], "go_terms": ["GO:0007342:fusion of sperm to egg plasma membrane involved in single fertilization:P", "GO:0016020:membrane:C", "GO:0035036:sperm-egg recognition:P", "GO:0005102:signaling receptor binding:F"], "name": "IZUMO1", "pathway_ids": ["R-MMU-1300645", "R-RNO-1300645", "R-HSA-1300645", "R-DRE-1300645"], "pathways": ["R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-DRE-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding"], "type": "Family"}, "IPR032701": {"description": "Prokaryotic E2 family B domain", "go_ids": [], "go_terms": [], "name": "Prok-E2_B_dom", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis"], "type": "Domain"}, "IPR032702": {"description": "CppA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CppA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032703": {"description": "CppA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CppA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032704": {"description": "Protein Cms1", "go_ids": [], "go_terms": [], "name": "Cms1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032705": {"description": "Origin recognition complex subunit 4, C-terminal", "go_ids": [], "go_terms": [], "name": "ORC4_C", "pathway_ids": ["R-DDI-68689", "R-RNO-68949", "R-HSA-68949", "R-SPO-176187", "R-RNO-68962", "R-SPO-68616", "R-BTA-68616", "R-MMU-68962", "R-HSA-113507", "R-BTA-68949", "R-MMU-68949", "R-RNO-176187", "R-DDI-68616", "R-HSA-68689", "R-SCE-68962", "R-BTA-68962", "R-BTA-176187", "R-SCE-68616", "R-HSA-68616", "R-BTA-68689", "R-RNO-68616", "R-DDI-68962", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-MMU-68689", "R-SPO-68962", "R-MMU-68616", "R-SPO-68949", "R-SCE-176187", "R-HSA-176187", "R-RNO-68689", "R-HSA-68867"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR032706": {"description": "Transcription elongation factor Spt6, helix-hairpin-helix motif", "go_ids": [], "go_terms": [], "name": "Spt6_HHH", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Domain"}, "IPR032707": {"description": "MYCBP-associated protein", "go_ids": [], "go_terms": [], "name": "MYCBPAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032708": {"description": "Microcin J25-processing protein McjB, C-terminal", "go_ids": [], "go_terms": [], "name": "McjB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032710": {"description": "NTF2-like domain superfamily", "go_ids": [], "go_terms": [], "name": "NTF2-like_dom_sf", "pathway_ids": ["R-RNO-877300", "R-CEL-159231", "R-HSA-5419276", "R-HSA-9022692", "R-HSA-6802952", "R-BTA-5673001", "R-CEL-159227", "R-MMU-4086398", "R-CEL-438066", "R-BTA-936837", "R-HSA-442982", "R-BTA-159227", "R-BTA-5576892", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-HSA-5673000", "R-DME-3371571", "R-CEL-159230", "R-HSA-9649948", "R-HSA-1268020", "R-HSA-5368286", "R-CEL-4086398", "R-RNO-3371571", "R-BTA-438066", "R-DRE-877300", "R-SSC-877300", "R-BTA-877300", "R-SSC-3371571", "R-HSA-5389840", "R-RNO-5673001", "R-MMU-5673001", "R-CEL-936837", "R-DME-438066", "R-DME-5673000", "R-HSA-6802955", "R-RNO-5673000", "R-SPO-159236", "R-MMU-438066", "R-MMU-5673000", "R-MMU-5578775", "R-BTA-3371571", "R-DME-159227", "R-RNO-438066", "R-MMU-159236", "R-HSA-5673001", "R-HSA-159231", "R-MMU-159227", "R-SSC-438066", "R-CEL-9937383", "R-HSA-9620244", "R-BTA-399719", "R-XTR-5419276", "R-HSA-159236", "R-DRE-3371571", "R-DME-5389840", "R-BTA-5673000", "R-HSA-9609736", "R-MMU-5389840", "R-HSA-9656223", "R-HSA-9705671", "R-MMU-9937383", "R-SPO-159227", "R-SPO-159231", "R-DRE-438066", "R-XTR-5389840", "R-CEL-3371571", "R-DME-159236", "R-DME-159231", "R-HSA-5576892", "R-XTR-9937383", "R-HSA-159227", "R-HSA-6802946", "R-BTA-5578775", "R-RNO-159236", "R-HSA-5578775", "R-HSA-111932", "R-HSA-4086398", "R-MMU-936837", "R-HSA-9617324", "R-HSA-9918481", "R-MMU-159231", "R-DME-4086398", "R-HSA-442729", "R-HSA-399719", "R-BTA-159230", "R-DME-936837", "R-CEL-5389840", "R-DME-5578775", "R-RNO-5578775", "R-HSA-9937383", "R-MMU-3371571", "R-HSA-936837", "R-RNO-399719", "R-RNO-159227", "R-MMU-877300", "R-RNO-936837", "R-DME-159230", "R-RNO-4086398", "R-SSC-5673001", "R-HSA-438066", "R-CEL-5578775", "R-RNO-159231", "R-HSA-877300", "R-HSA-3371571", "R-MMU-5419276", "R-DME-5419276", "R-BTA-159236", "R-BTA-159231", "R-CEL-5419276", "R-SSC-399719", "R-DME-9937383", "R-MMU-399719", "R-CEL-159236"], "pathways": ["R-RNO-877300:r:Interferon gamma signaling", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-5419276:r:Mitochondrial translation termination", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-4086398:r:Ca2+ pathway", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-5673000:r:RAF activation", "R-DME-3371571:r:HSF1-dependent transactivation", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-4086398:r:Ca2+ pathway", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DRE-877300:r:Interferon gamma signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-BTA-877300:r:Interferon gamma signaling", "R-SSC-3371571:r:HSF1-dependent transactivation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-5673000:r:RAF activation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-RNO-5673000:r:RAF activation", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5673000:r:RAF activation", "R-MMU-5578775:r:Ion homeostasis", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-SSC-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9620244:r:Long-term potentiation", "R-BTA-399719:r:Trafficking of AMPA receptors", "R-XTR-5419276:r:Mitochondrial translation termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-3371571:r:HSF1-dependent transactivation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-BTA-5673000:r:RAF 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[], "type": "Domain"}, "IPR032738": {"description": "TBC1 domain family member 30, C-terminal", "go_ids": [], "go_terms": [], "name": "Tbc1d30_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032739": {"description": "MRN complex-interacting protein", "go_ids": [], "go_terms": [], "name": "MRNIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032740": {"description": "SGNH hydrolase-type esterase, N-terminal", "go_ids": [], "go_terms": [], "name": "GxDLY", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032741": {"description": "SLS1, first KH domain", "go_ids": ["GO:0005743"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C"], "name": "Sls1_KH-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032742": {"description": "INO80 complex subunit 3, N-terminal", "go_ids": ["GO:0031011", "GO:0005634", "GO:0006338"], "go_terms": ["GO:0031011:Ino80 complex:C", "GO:0005634:nucleus:C", "GO:0006338:chromatin remodeling:P"], "name": "Iec3_N", 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{"description": "Tankyrase 1-binding protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Tankyrase-bd_C", "pathway_ids": ["R-MMU-6804115", "R-HSA-6804115", "R-MMU-429947", "R-HSA-429947", "R-HSA-9820841"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR032765": {"description": "Testis expressed sequence 15 domain", "go_ids": [], "go_terms": [], "name": "TEX15_dom", "pathway_ids": ["R-HSA-912446"], "pathways": ["R-HSA-912446:r:Meiotic recombination"], "type": "Domain"}, "IPR032766": {"description": "Fission yeast Sec3, C-terminal", "go_ids": [], "go_terms": [], "name": "Sec3_C_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032767": {"description": "Ascaris metallocarboxypeptidase inhibitor", "go_ids": ["GO:0008191"], "go_terms": ["GO:0008191:metalloendopeptidase inhibitor activity:F"], "name": "ACI44", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032768": {"description": "G2 and S phase-expressed protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "GTSE1_N", "pathway_ids": ["R-HSA-8852276", "R-MMU-69481", "R-HSA-69481", "R-MMU-8852276"], "pathways": ["R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-69481:r:G2/M Checkpoints", "R-HSA-69481:r:G2/M Checkpoints", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint"], "type": "Domain"}, "IPR032769": {"description": "Nck-associated protein 5, C-terminal", "go_ids": [], "go_terms": [], "name": "NCKAP5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032770": {"description": "Domain of unknown function DUF4537", "go_ids": [], "go_terms": [], "name": "DUF4537", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032771": {"description": "Protein of unknown function DUF4527", "go_ids": [], "go_terms": [], "name": "DUF4527", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032772": {"description": "Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, C-terminal", "go_ids": [], "go_terms": [], "name": "PGA_deacetylase_PgaB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032773": {"description": "Protein MGARP, N-terminal", "go_ids": [], "go_terms": [], "name": "MGARP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032774": {"description": "WG containing repeat", "go_ids": [], "go_terms": [], "name": "WG_beta_rep", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR032776": {"description": "CECR6/TMEM121 family", "go_ids": [], "go_terms": [], "name": "CECR6/TMEM121", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032777": {"description": "Domain of unknown function DUF4515", "go_ids": [], "go_terms": [], "name": "DUF4515", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032778": {"description": "Growth factor receptor domain 4", "go_ids": [], "go_terms": [], "name": "GF_recep_IV", "pathway_ids": ["R-MMU-1250342", "R-RNO-1306955", "R-MMU-8856828", "R-MMU-180336", "R-RNO-1250347", "R-HSA-8963889", "R-MMU-6811558", "R-HSA-9665251", "R-DME-9652282", "R-MMU-9009391", "R-HSA-1306955", "R-RNO-9018519", "R-RNO-8863795", "R-HSA-8863795", "R-RNO-8847993", "R-RNO-6811558", "R-CEL-1257604", "R-RNO-1963642", "R-MMU-9652282", "R-MMU-1236394", "R-HSA-9013507", "R-DME-1251985", "R-CEL-182971", "R-MMU-5673001", "R-HSA-182971", "R-DME-6785631", "R-DME-212718", "R-DME-1253288", "R-HSA-9609690", "R-HSA-5637810", "R-HSA-9820960", "R-DME-416572", "R-DME-1257604", "R-MMU-179812", "R-MMU-1963642", "R-HSA-445144", "R-MMU-1250196", "R-DME-182971", "R-CEL-6811558", "R-DME-1963642", "R-HSA-179812", "R-HSA-9768727", "R-CEL-8856825", "R-HSA-8857538", "R-HSA-5638303", "R-DME-180336", "R-DME-5673001", "R-DME-1358803", "R-HSA-416572", "R-CEL-1227986", "R-HSA-1251985", "R-RNO-1257604", "R-HSA-9665737", "R-HSA-9665348", "R-CEL-2179392", "R-RNO-1253288", "R-HSA-1181150", "R-MMU-8847993", "R-MMU-9013507", "R-MMU-1250347", "R-HSA-1963642", "R-HSA-1250196", "R-MMU-167060", "R-DME-8863795", "R-RNO-1251985", "R-HSA-1963640", "R-DME-1250342", "R-CEL-8856828", "R-HSA-9665249", "R-RNO-1250342", "R-DME-2179392", "R-MMU-1227986", "R-RNO-1227986", "R-HSA-6785631", "R-MMU-1257604", "R-HSA-9665250", "R-DME-177929", "R-HSA-1358803", "R-HSA-9634638", "R-HSA-180336", "R-MMU-1251985", "R-HSA-9009391", "R-MMU-212718", "R-CEL-179812", "R-HSA-9634285", "R-HSA-8856825", "R-CEL-9009391", "R-MMU-1963640", "R-MMU-1253288", "R-MMU-6785631", "R-MMU-182971", "R-HSA-180292", "R-MMU-1306955", "R-HSA-8856828", "R-CEL-1253288", "R-CEL-9652282", "R-RNO-416572", "R-HSA-2179392", "R-HSA-9927418", "R-CEL-5673001", "R-MMU-416572", "R-HSA-177929", "R-RNO-8963889", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-9652282", "R-RNO-5673001", "R-CEL-6785631", "R-HSA-9018519", "R-RNO-9768727", "R-HSA-212718", "R-DME-1227986", "R-HSA-9665244", "R-HSA-9665686", "R-DME-1236394", "R-MMU-180292", "R-HSA-8847993", "R-DME-9018519", "R-CEL-180292", "R-CEL-177929", "R-HSA-2219530", "R-MMU-445144", "R-CEL-1250196", "R-HSA-5673001", "R-HSA-6811558", "R-MMU-9018519", "R-CEL-212718", "R-DME-445144", "R-HSA-9620244", "R-RNO-1358803", "R-DME-1250196", "R-HSA-1253288", "R-HSA-167060", "R-DME-1963640", "R-RNO-9652282", "R-HSA-1257604", "R-MMU-8863795", "R-MMU-2179392", "R-CEL-8863795", "R-RNO-6785631", "R-HSA-6809371", "R-MMU-8856825", "R-HSA-1251932", "R-HSA-1250342", "R-HSA-1250347", "R-HSA-9665245", "R-CEL-1251985", "R-DME-6811558", "R-CEL-8847993", "R-HSA-8866910", "R-HSA-1236382", "R-DME-8856828", "R-HSA-9938206", "R-DME-1250347", "R-MMU-1358803", "R-DME-8856825", "R-DME-180292", "R-HSA-9665246", "R-RNO-1963640", "R-CEL-445144", "R-HSA-9927432", "R-HSA-1227986", "R-HSA-9665233", "R-MMU-8963889", "R-CEL-416572", "R-CEL-180336", "R-HSA-1236394", "R-CEL-1963642", "R-RNO-167060", "R-RNO-1236394", "R-RNO-1250196", "R-DME-179812", "R-MMU-8857538", "R-MMU-177929"], "pathways": ["R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-1236394:r:Signaling by ERBB4", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-CEL-182971:r:EGFR downregulation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-182971:r:EGFR downregulation", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-182971:r:EGFR downregulation", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-1227986:r:Signaling by ERBB2", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-1181150:r:Signaling by NODAL", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-167060:r:NGF processing", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-1227986:r:Signaling by ERBB2", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-DME-177929:r:Signaling by EGFR", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-182971:r:EGFR downregulation", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-CEL-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-177929:r:Signaling by EGFR", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-CEL-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DME-1236394:r:Signaling by ERBB4", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-CEL-180292:r:GAB1 signalosome", "R-CEL-177929:r:Signaling by EGFR", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-CEL-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9620244:r:Long-term potentiation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-167060:r:NGF processing", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-180292:r:GAB1 signalosome", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-HSA-1236394:r:Signaling by ERBB4", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-167060:r:NGF processing", "R-RNO-1236394:r:Signaling by ERBB4", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-177929:r:Signaling by EGFR"], "type": "Domain"}, "IPR032779": {"description": "Flagellar motor switch protein FliG, middle domain", "go_ids": [], "go_terms": [], "name": "FliG_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032780": {"description": "DNA polymerase III subunit delta, C-terminal", "go_ids": [], "go_terms": [], "name": "DNA_pol3_delt_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032781": {"description": "ABC-transporter extension domain", "go_ids": [], "go_terms": [], "name": "ABC_tran_Xtn", "pathway_ids": ["R-DDI-382556", "R-HSA-9818032"], "pathways": ["R-DDI-382556:r:ABC-family proteins mediated transport", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes"], "type": "Domain"}, "IPR032782": {"description": "RNA-binding protein KhpB, N-terminal", "go_ids": [], "go_terms": [], "name": "KhpB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032783": {"description": "AraC-type transcription regulator, ligand-binding domain", "go_ids": [], "go_terms": [], "name": "AraC_lig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032784": {"description": "2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, middle domain", "go_ids": [], "go_terms": [], "name": "THDPS_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032785": {"description": "Replicase polyprotein 1ab, peptidase C33-associated domain", "go_ids": [], "go_terms": [], "name": "Pdase_C33_assoc", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR032786": {"description": "Nsp2, transmembrane domain", "go_ids": [], "go_terms": [], "name": "NSP2_TM_arteriviridae", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032787": {"description": "Prokaryotic E2 family D", "go_ids": [], "go_terms": [], "name": "Prok-E2_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032788": {"description": "Glycogen debranching enzyme, central domain", "go_ids": [], "go_terms": [], "name": "AGL_central", "pathway_ids": ["PWY-7238", "PWY-6724", "PWY-5941", "PWY-6737", "R-SCE-70221", "R-HSA-6798695", "R-HSA-70221", "R-SCE-6798695"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6724:t:starch degradation II", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-SCE-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR032789": {"description": "Pilus formation protein, N-terminal", "go_ids": [], "go_terms": [], "name": "T2SS-T3SS_pil_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032790": {"description": "Glycogen debranching enzyme, C-terminal", "go_ids": [], "go_terms": [], "name": "GDE_C", "pathway_ids": ["PWY-7238", "PWY-6724", "PWY-5941", "PWY-6737", "R-SCE-70221", "R-HSA-6798695", "R-HSA-70221", "R-SCE-6798695"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6724:t:starch degradation II", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-SCE-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR032791": {"description": "Uncharacterised protein YhfZ, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YhfZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032792": {"description": "Glycogen debranching enzyme, glucanotransferase domain", "go_ids": [], "go_terms": [], "name": "AGL_glucanoTrfase", "pathway_ids": ["PWY-7238", "PWY-6724", "PWY-5941", "PWY-6737", "R-SCE-70221", "R-HSA-6798695", "R-HSA-70221", "R-SCE-6798695"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6724:t:starch degradation II", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-SCE-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR032793": {"description": "Type II restriction endonuclease EcoO109IR", "go_ids": [], "go_terms": [], "name": "RE_EcoO109IR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032794": {"description": "Protein Lines, N-terminal", "go_ids": [], "go_terms": [], "name": "LINES_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032795": {"description": "DUF3741-associated sequence motif", "go_ids": [], "go_terms": [], "name": "DUF3741-assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032796": {"description": "Polysulfide reductase", "go_ids": [], "go_terms": [], "name": "NrfD_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032797": {"description": "Gamma-Tubulin ring complex non-core subunit mod21, N-terminal", "go_ids": [], "go_terms": [], "name": "Mod21_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032798": {"description": "Endoglucanase Z, cellulose-binding domain", "go_ids": [], "go_terms": [], "name": "CBM_5_12_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032799": {"description": "Xylanase inhibitor, C-terminal", "go_ids": [], "go_terms": [], "name": "TAXi_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032800": {"description": "ML-like domain", "go_ids": [], "go_terms": [], "name": "TRP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032801": {"description": "Peroxiredoxin-like 2A/B/C", "go_ids": [], "go_terms": [], "name": "PXL2A/B/C", "pathway_ids": ["R-HSA-2162123"], "pathways": ["R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "type": "Family"}, "IPR032803": {"description": "PLD3/4-like, PLD-like domain", "go_ids": [], "go_terms": [], "name": "PLDc_3", "pathway_ids": ["R-DDI-1855204", "R-CEL-1855204", "R-RNO-2029485", "R-HSA-1855204", "R-MMU-2029485", "R-HSA-2029485", "R-DDI-2029485", "R-MMU-1855204", "R-HSA-1483148", "R-XTR-2029485", "R-CEL-2029485", "R-BTA-2029485"], "pathways": ["R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1483148:r:Synthesis of PG", "R-XTR-2029485:r:Role of phospholipids in phagocytosis", "R-CEL-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-2029485:r:Role of phospholipids in phagocytosis"], "type": "Domain"}, "IPR032805": {"description": "Wax synthase domain", "go_ids": [], "go_terms": [], "name": "Wax_synthase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032806": {"description": "H repeat-associated protein, N-terminal", "go_ids": [], "go_terms": [], "name": "YbfD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032807": {"description": "Tyrosine-protein kinase, G-rich domain", "go_ids": [], "go_terms": [], "name": "GNVR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032808": {"description": "DoxX family", "go_ids": [], "go_terms": [], "name": "DoxX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032809": {"description": "Putative HupE/UreJ protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Put_HupE_UreJ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032810": {"description": "CCA-adding enzyme, C-terminal", "go_ids": [], "go_terms": [], "name": "CCA-adding_enz_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032811": {"description": "Putative conjugal transfer protein TraF-related", "go_ids": [], "go_terms": [], "name": "Put_conjugal_transfer", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032812": {"description": "SbsA, Ig-like domain", "go_ids": [], "go_terms": [], "name": "SbsA_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032813": {"description": "Putative Na+/H+ antiporter, N-terminal", "go_ids": [], "go_terms": [], "name": "Na_H_antiport_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032815": {"description": "Peptidase S8, pro-domain", "go_ids": [], "go_terms": [], "name": "S8_pro-domain", "pathway_ids": ["R-HSA-186797", "R-CEL-1592389", "R-DME-2173789", "R-HSA-159782", "R-HSA-171286", "R-HSA-8963889", "R-HSA-264876", "R-HSA-9918485", "R-CEL-1566948", "R-MMU-422085", "R-MMU-1912420", "R-HSA-9828806", "R-RNO-8963889", "R-RNO-422085", "R-HSA-5210891", "R-MMU-1566948", "R-HSA-209952", "R-RNO-9768727", "R-HSA-2173789", "R-MMU-1592389", "R-MMU-2173796", "R-CEL-2173796", "R-HSA-9694614", "R-DME-1592389", "R-RNO-1566948", "R-HSA-422085", "R-HSA-9820960", "R-HSA-9918476", "R-HSA-167060", "R-HSA-9768727", "R-MMU-186797", "R-MMU-9768727", "R-RNO-2173796", "R-HSA-6809371", "R-HSA-9662834", "R-HSA-977225", "R-RNO-159782", "R-HSA-1566948", "R-MMU-209952", "R-MMU-9953170", "R-HSA-1181150", "R-DME-8963889", "R-MMU-167060", "R-HSA-381771", "R-HSA-2173796", "R-RNO-2173789", "R-HSA-1442490", "R-HSA-400511", "R-HSA-1912420", "R-RNO-9953170", "R-MMU-2173789", "R-HSA-9733458", "R-RNO-1592389", "R-RNO-186797", "R-MMU-8963889", "R-HSA-9679191", "R-HSA-1592389", "R-RNO-1442490", "R-RNO-209952", "R-MMU-159782", "R-RNO-167060", "R-DME-2173796", "R-CEL-186797", "R-MMU-1442490", "R-HSA-9953170", "R-DME-186797"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-171286:r:Synthesis and processing of ENV and VPU", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-264876:r:Insulin processing", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-CEL-1566948:r:Elastic fibre formation", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-209952:r:Peptide hormone biosynthesis", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9694614:r:Attachment and Entry", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1566948:r:Elastic fibre formation", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-167060:r:NGF processing", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-1566948:r:Elastic fibre formation", "R-MMU-209952:r:Peptide hormone biosynthesis", "R-MMU-9953170:r:GBP-mediated host defense", "R-HSA-1181150:r:Signaling by NODAL", "R-DME-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-167060:r:NGF processing", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-1442490:r:Collagen degradation", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-RNO-9953170:r:GBP-mediated host defense", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1442490:r:Collagen degradation", "R-RNO-209952:r:Peptide hormone biosynthesis", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-167060:r:NGF processing", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-186797:r:Signaling by PDGF", "R-MMU-1442490:r:Collagen degradation", "R-HSA-9953170:r:GBP-mediated host defense", "R-DME-186797:r:Signaling by PDGF"], "type": "Domain"}, "IPR032816": {"description": "VTT domain", "go_ids": [], "go_terms": [], "name": "VTT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032817": {"description": "Mon2, C-terminal", "go_ids": [], "go_terms": [], "name": "Mon2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032818": {"description": "DedA-like", "go_ids": ["GO:0022857", "GO:0055085"], "go_terms": ["GO:0022857:transmembrane transporter activity:F", "GO:0055085:transmembrane transport:P"], "name": "DedA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032819": {"description": "tRNA pseudouridylate synthase B, C-terminal", "go_ids": [], "go_terms": [], "name": "TruB_C", "pathway_ids": ["R-CEL-171319", "R-SPO-171319", "R-GGA-417076", "R-DME-171319", "R-SCE-171319", "R-DRE-171319", "R-RNO-171319", "R-DDI-171319", "R-HSA-6790901", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-CEL-171319:r:Telomere Extension By Telomerase", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-GGA-417076:r:Assembly of telomerase and telomere extension", "R-DME-171319:r:Telomere Extension By Telomerase", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DDI-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR032820": {"description": "Putative F0F1-ATPase subunit, Ca2+/Mg2+ transporter", "go_ids": [], "go_terms": [], "name": "ATPase_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032821": {"description": "Polyketide synthase, C-terminal extension", "go_ids": [], "go_terms": [], "name": "PKS_assoc", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-DDI-75105", "R-HSA-75105", "R-DDI-199220", "R-HSA-9918487", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR032823": {"description": "Branched-chain amino acid ATP-binding cassette transporter, C-terminal", "go_ids": [], "go_terms": [], "name": "BCA_ABC_TP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032826": {"description": "Flagellin, H7-serospecific domain", "go_ids": [], "go_terms": [], "name": "FliC_H7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032828": {"description": "tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain", "go_ids": [], "go_terms": [], "name": "PolyA_RNA-bd", "pathway_ids": ["R-HSA-6785470", "R-HSA-6784531"], "pathways": ["R-HSA-6785470:r:tRNA processing in the mitochondrion", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR032830": {"description": "Helicase XPB/Ssl2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "XPB/Ssl2_N", "pathway_ids": ["R-SCE-674695", "R-MMU-6782210", "R-RNO-75953", "R-SCE-6782135", "R-DDI-6782135", "R-MMU-73762", "R-MMU-6782135", "R-BTA-113418", "R-DME-6796648", "R-HSA-72086", "R-HSA-167162", "R-DRE-5696395", "R-DRE-73863", "R-DRE-77075", "R-GGA-353303", "R-HSA-167152", "R-HSA-113418", "R-BTA-5696395", "R-SCE-6782210", "R-BTA-6796648", "R-SCE-6796648", "R-BTA-73762", "R-RNO-72086", "R-SPO-77075", "R-RNO-73772", "R-DRE-76042", "R-SCE-113418", "R-SCE-72086", "R-RNO-6782135", "R-MMU-73863", "R-DRE-72086", "R-HSA-6782135", "R-HSA-73762", "R-DRE-674695", "R-SPO-5696400", "R-SCE-77075", "R-DDI-75953", "R-SPO-6782135", "R-DME-73772", "R-RNO-6781823", "R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-RNO-73779", "R-HSA-427413", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-RNO-73776", "R-DRE-75955", "R-SPO-76042", "R-HSA-73776", "R-DME-72086", "R-BTA-77075", "R-DDI-674695", "R-SPO-6796648", "R-DME-75953", "R-DME-6782135", "R-BTA-73863", "R-BTA-75955", "R-DRE-6782210", "R-BTA-75953", "R-BTA-6782135", "R-RNO-5696395", "R-HSA-167161", "R-DME-112382", "R-HSA-5696395", "R-DDI-77075", "R-HSA-167160", "R-DDI-113418", "R-SPO-73779", "R-MMU-73772", "R-MMU-72086", "R-BTA-6782210", "R-BTA-73776", "R-SPO-73776", "R-BTA-73772", "R-SCE-73776", "R-DDI-5696395", "R-HSA-6781827", "R-DRE-5696400", "R-DME-73779", "R-DME-77075", "R-DME-73776", "R-MMU-6781823", "R-BTA-6781823", "R-DDI-73772", "R-DDI-6796648", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696400", "R-HSA-167172", "R-DRE-6781823", "R-MMU-5696400", "R-BTA-73779", "R-SCE-73779", "R-DME-113418", "R-RNO-113418", "R-MMU-6796648", "R-RNO-6796648", "R-DRE-73772", "R-RNO-75955", "R-SCE-6781823", "R-DME-5696395", "R-BTA-674695", "R-DRE-73776", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-DRE-6782135", "R-MMU-77075", "R-HSA-75955", "R-DME-5696400", "R-SPO-6782210", "R-RNO-5696400", "R-HSA-5696400", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-SCE-73772", "R-HSA-112382", "R-HSA-73779", "R-RNO-674695", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-DRE-73779", "R-BTA-76042", "R-RNO-73863", "R-DRE-75953", "R-HSA-6796648", "R-HSA-6781823", "R-SPO-5696395", "R-HSA-167246", "R-MMU-5696395", "R-DRE-6796648", "R-DRE-113418", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-RNO-6782210", "R-SPO-113418", "R-DDI-73779", "R-DME-674695", "R-BTA-72086", "R-RNO-76042", "R-DDI-6781823", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-SCE-76042", "R-HSA-167200", "R-RNO-112382"], "pathways": ["R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72086:r:mRNA Capping", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-353303:r:Nucleotide Excision Repair", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72086:r:mRNA Capping", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-6782135:r:Dual incision in TC-NER", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-6782135:r:Dual incision in TC-NER", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR032831": {"description": "LPS-assembly lipoprotein LptM, conserved region", "go_ids": [], "go_terms": [], "name": "LptM_cons", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR032834": {"description": "Sensor histidine kinase NatK-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NatK-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032835": {"description": "Rho GTPase-activating protein, FF domain", "go_ids": [], "go_terms": [], "name": "RhoGAP-FF1", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9013405", "R-CFA-9013409", "R-HSA-416550", "R-MMU-9013106", "R-RNO-9013409", "R-RNO-9696270", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9013409", "R-CFA-9013404", "R-MMU-9013148", "R-HSA-9013106", "R-MMU-9013404", "R-RNO-416550", "R-CFA-9013149", "R-HSA-8849471", "R-HSA-9013423", "R-CFA-8849471", "R-DME-9035034", "R-DME-9013148", "R-CFA-9696264", "R-CFA-9013408", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013409", "R-DME-9013406", "R-RNO-9013408", "R-RNO-9013106", "R-RNO-9013406", "R-RNO-9013404", "R-CFA-9696270", "R-HSA-9013408", "R-MMU-8849471", "R-DME-350407", "R-MMU-9035034", "R-RNO-8849471", "R-CFA-9013406", "R-CFA-9013148", "R-DME-9013149", "R-CFA-8980692", "R-DME-8980692", "R-HSA-9696270", "R-CFA-416550", "R-RNO-9013148", "R-RNO-9696273", "R-CFA-9696273", "R-HSA-9696264", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-416550", "R-CFA-9013106", "R-MMU-9013406", "R-MMU-9013026", "R-RNO-9696264", "R-HSA-9013026", "R-DME-8849471", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9013149", "R-DME-9013423", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-CFA-9013409:r:RHOJ GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-9035034:r:RHOF GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-CFA-9696264:r:RND3 GTPase cycle", "R-CFA-9013408:r:RHOG GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-CFA-9696270:r:RND2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-350407:r:RHO1 GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CFA-8980692:r:RHOA GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-CFA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR032836": {"description": "DsrE2-like family", "go_ids": [], "go_terms": [], "name": "DsrE2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032837": {"description": "Glycerol-1-phosphate dehydrogenase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "G1PDH_N", "pathway_ids": ["PWY-8365", "PWY-6349"], "pathways": ["PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-6349:t:C20,20 CDP-archaeol biosynthesis"], "type": "Domain"}, "IPR032838": {"description": "VWA-Hint protein, Vwaint domain", "go_ids": [], "go_terms": [], "name": "Vwaint_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032839": {"description": "Rab3-GAP regulatory subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "RAB3GAP_N", "pathway_ids": ["R-RNO-6811436", "R-MMU-8876198", "R-CEL-8876198", "R-DME-6811436", "R-DME-8876198", "R-CEL-6811436", "R-RNO-8876198", "R-HSA-8876198", "R-HSA-6811436", "R-MMU-6811436"], "pathways": ["R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR032840": {"description": "CFAP91 domain", "go_ids": [], "go_terms": [], "name": "CFAP91_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032841": {"description": "Arterivirus polyprotein, nsp2, non-essential region", "go_ids": [], "go_terms": [], "name": "NSP2_assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032843": {"description": "Cleavage inducing molecular chaperone, Jiv", "go_ids": [], "go_terms": [], "name": "Jiv", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032847": {"description": "Pre-mRNA-processing factor 17", "go_ids": ["GO:0000398", "GO:0071013"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P", "GO:0071013:catalytic step 2 spliceosome:C"], "name": "PRPF17", "pathway_ids": ["R-SPO-9770562", "R-HSA-72163", "R-MMU-72187", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-HSA-73856", "R-MMU-73856", "R-HSA-159236", "R-HSA-72187", "R-SPO-72163", "R-HSA-9918481", "R-MMU-159236"], "pathways": ["R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR032848": {"description": "Sex-determining transformer protein 2", "go_ids": ["GO:0040021", "GO:0042001", "GO:0004888"], "go_terms": ["GO:0040021:hermaphrodite germ-line sex determination:P", "GO:0042001:hermaphrodite somatic sex determination:P", "GO:0004888:transmembrane signaling receptor activity:F"], "name": "Ce-Tra-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032852": {"description": "DNA oxidative demethylase ALKBH2", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "ALKBH2", "pathway_ids": ["R-HSA-112122"], "pathways": ["R-HSA-112122:r:ALKBH2 mediated reversal of alkylation damage"], "type": "Family"}, "IPR032854": {"description": "Alkylated DNA repair protein alkB homologue 3", "go_ids": ["GO:0006281", "GO:0006307", "GO:0051213"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0006307:DNA alkylation repair:P", "GO:0051213:dioxygenase activity:F"], "name": "ALKBH3", "pathway_ids": ["R-HSA-112126"], "pathways": ["R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage"], "type": "Family"}, "IPR032855": {"description": "Arterivirus polyprotein, nsp2, immunogenic region", "go_ids": [], "go_terms": [], "name": "NSP2-B_epitope", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR032856": {"description": "Putative glycogen debranching enzyme, N-terminal", "go_ids": [], "go_terms": [], "name": "GDE_N_bis", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032857": {"description": "Alpha-ketoglutarate-dependent dioxygenase alkB homologue 4", "go_ids": ["GO:0070988"], "go_terms": ["GO:0070988:demethylation:P"], "name": "ALKBH4", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR032858": {"description": "Cbb3-type cytochrome c oxidase subunit CcoP, N-terminal", "go_ids": [], "go_terms": [], "name": "CcoP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032859": {"description": "GTPase Der, C-terminal KH-domain-like", "go_ids": [], "go_terms": [], "name": "KH_dom-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032860": {"description": "RNA demethylase ALKBH5", "go_ids": ["GO:0006397", "GO:0035515"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:0035515:oxidative RNA demethylase activity:F"], "name": "ALKBH5", "pathway_ids": ["R-MMU-73943", "R-XTR-73943", "R-HSA-73943", "R-DRE-73943", "R-RNO-73943"], "pathways": ["R-MMU-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-XTR-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-HSA-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-DRE-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-RNO-73943:r:Reversal of alkylation damage by DNA dioxygenases"], "type": "Family"}, "IPR032861": {"description": "Xylanase 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"PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR032864": {"description": "Y4jF, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Y4jF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032865": {"description": "Prokaryotic E2 family A", "go_ids": [], "go_terms": [], "name": "Prok-E2_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032866": {"description": "Prokaryotic Ubiquitin", "go_ids": [], "go_terms": [], "name": "Prok_Ub", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032867": {"description": "DYW domain", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "DYW_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR032868": {"description": "Alpha-ketoglutarate-dependent dioxygenase FTO", "go_ids": ["GO:0042245", "GO:0006307", "GO:0040014", "GO:0035515", "GO:0035516"], "go_terms": ["GO:0042245:RNA repair:P", "GO:0006307:DNA alkylation repair:P", "GO:0040014:regulation of multicellular organism growth:P", "GO:0035515:oxidative RNA demethylase activity:F", "GO:0035516:broad specificity oxidative DNA demethylase activity:F"], "name": "FTO", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-HSA-73943", "R-RNO-73943", "R-MMU-73943"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides 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"R-HSA-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-RNO-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-MMU-73943:r:Reversal of alkylation damage by DNA dioxygenases"], "type": "Family"}, "IPR032869": {"description": "WHH domain-containing protein", "go_ids": [], "go_terms": [], "name": "WHH_dom_containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032870": {"description": "Alpha-ketoglutarate-dependent dioxygenase alkB homologue 7-like", "go_ids": ["GO:0006974"], "go_terms": ["GO:0006974:DNA damage response:P"], "name": "ALKBH7-like", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", 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"SrkA/RdoA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032884": {"description": "NAD-dependent glucose-6-phosphate dehydrogenase, archaea", "go_ids": ["GO:0006098", "GO:0004345", "GO:0070403"], "go_terms": ["GO:0006098:pentose-phosphate shunt:P", "GO:0004345:glucose-6-phosphate dehydrogenase activity:F", "GO:0070403:NAD+ binding:F"], "name": "Glc6PDH_archaea", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032895": {"description": "ECA polysaccharide chain length modulation protein WzzE", "go_ids": ["GO:0009246", "GO:0016020"], "go_terms": ["GO:0009246:enterobacterial common antigen biosynthetic process:P", "GO:0016020:membrane:C"], "name": "WzzE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032896": {"description": "Lipid III flippase WzxE, Proteobacteria", "go_ids": ["GO:0009246", "GO:0005886"], "go_terms": ["GO:0009246:enterobacterial common antigen biosynthetic process:P", "GO:0005886:plasma membrane:C"], "name": "WzxE_Proteobacteria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032898": {"description": "Cell division protein DedD", "go_ids": ["GO:0030428", "GO:0032506"], "go_terms": ["GO:0030428:cell septum:C", "GO:0032506:cytokinetic process:P"], "name": "DedD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032900": {"description": "PanD regulatory factor PanZ", "go_ids": ["GO:0031638", "GO:0015940"], "go_terms": ["GO:0031638:zymogen activation:P", "GO:0015940:pantothenate biosynthetic process:P"], "name": "PanZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032914": {"description": "Vam6/VPS39/TRAP1 family", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "Vam6/VPS39/TRAP1", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Family"}, "IPR032940": {"description": "Calmodulin-regulated spectrin-associated protein", "go_ids": ["GO:0008017", "GO:0005516"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0005516:calmodulin binding:F"], "name": "CAMSAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032942": {"description": "BPI/LBP/Plunc family", "go_ids": [], "go_terms": [], "name": "BPI/LBP/Plunc", "pathway_ids": ["R-RNO-5686938", "R-HSA-6798695", "R-DDI-6798695", "R-RNO-6798695", "R-RNO-6803157", "R-BTA-6803157", "R-HSA-8964058", "R-DDI-166016", "R-HSA-166016", "R-MMU-166016", "R-BTA-6798695", "R-CEL-5686938", "R-HSA-6785807", "R-MMU-5686938", "R-MMU-166020", "R-BTA-166016", "R-MMU-8964058", "R-HSA-166020", "R-HSA-6803157", "R-MMU-6798695", "R-CEL-166016", "R-MMU-6803157", "R-HSA-5686938", "R-RNO-166016", "R-HSA-9029569", "R-DDI-6803157", "R-RNO-166020", "R-DDI-5686938"], "pathways": ["R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-BTA-6803157:r:Antimicrobial peptides", "R-HSA-8964058:r:HDL remodeling", "R-DDI-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-166020:r:Transfer of LPS from LBP carrier to CD14", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-8964058:r:HDL remodeling", "R-HSA-166020:r:Transfer of LPS from LBP carrier to CD14", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DDI-6803157:r:Antimicrobial peptides", "R-RNO-166020:r:Transfer of LPS from LBP carrier to CD14", "R-DDI-5686938:r:Regulation of TLR by endogenous ligand"], "type": "Family"}, "IPR032946": {"description": "BPI fold-containing family A member 3", "go_ids": [], "go_terms": [], "name": "Bpifa3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032963": {"description": "Glutamate--cysteine ligase regulatory subunit", "go_ids": ["GO:0006750", "GO:0035226"], "go_terms": ["GO:0006750:glutathione biosynthetic process:P", "GO:0035226:glutamate-cysteine ligase catalytic subunit binding:F"], "name": "Gclm", "pathway_ids": ["R-HSA-5578999", "R-RNO-174403", "R-HSA-174403", "R-BTA-174403", "R-MMU-174403", "R-SPO-174403", "R-HSA-9818027"], "pathways": ["R-HSA-5578999:r:Defective GCLC causes HAGGSD", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes"], "type": "Family"}, "IPR032974": {"description": "Polyprenol kinase family", "go_ids": [], "go_terms": [], "name": "Polypren_kinase", "pathway_ids": ["PWY-6129", "R-HSA-446199", "R-MMU-446199", "R-SPO-446199", "R-BTA-446199", "R-HSA-4755583", "R-SCE-446199"], "pathways": ["PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-4755583:r:Defective DOLK causes DOLK-CDG", "R-SCE-446199:r:Synthesis of dolichyl-phosphate"], "type": "Family"}, "IPR032976": {"description": "YjeF N-terminal domain-containing protein NAXE-like", "go_ids": [], "go_terms": [], "name": "YJEFN_prot_NAXE-like", "pathway_ids": ["PWY-6938", "PWY-8137", "PWY-8136", "R-SPO-196807", "R-MMU-196807", "R-DME-196807", "R-DRE-196807", "R-SCE-196807", "R-CEL-196807", "R-HSA-196807", "R-PFA-196807", "R-DDI-196807", "R-RNO-196807"], "pathways": ["PWY-6938:t:NADH repair (eukaryotes)", "PWY-8137:t:NADPH repair (eukaryotes)", "PWY-8136:t:NADPH repair (prokaryotes)", "R-SPO-196807:r:Nicotinate metabolism", "R-MMU-196807:r:Nicotinate metabolism", "R-DME-196807:r:Nicotinate metabolism", "R-DRE-196807:r:Nicotinate metabolism", "R-SCE-196807:r:Nicotinate metabolism", "R-CEL-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-PFA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism"], "type": "Family"}, "IPR032978": {"description": "Zinc finger MYND domain-containing protein 19", "go_ids": [], "go_terms": [], "name": "ZMYND19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR032979": 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"R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR033102": {"description": "Negative elongation factor E", "go_ids": ["GO:0032021", "GO:0006355"], "go_terms": ["GO:0032021:NELF complex:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "NELFE", "pathway_ids": ["R-BTA-75955", "R-DME-113418", "R-MMU-6796648", "R-HSA-167238", "R-DME-674695", "R-MMU-113418", "R-HSA-167243", "R-BTA-113418", "R-DME-6796648", "R-HSA-167242", "R-BTA-674695", "R-DME-75955", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167200", "R-HSA-167290", "R-HSA-75955", "R-HSA-167152", "R-HSA-113418", "R-BTA-112382", "R-HSA-674695", "R-BTA-6796648", "R-HSA-112382"], "pathways": ["R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Family"}, "IPR033118": {"description": "EXPERA domain", "go_ids": [], "go_terms": [], "name": "EXPERA", "pathway_ids": ["R-DDI-9969901", "R-HSA-6807047", "R-MMU-9969901", "R-HSA-9969901", "R-MMU-6807047", "R-RNO-6807047", "R-DDI-6807047", "R-RNO-9969901"], "pathways": ["R-DDI-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-HSA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-HSA-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-MMU-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-DDI-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-RNO-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "type": "Domain"}, "IPR033121": {"description": "Peptidase family A1 domain", "go_ids": [], "go_terms": [], "name": "PEPTIDASE_A1", "pathway_ids": ["R-SPO-2132295", "R-HSA-6798695", "R-SPO-6798695", "R-HSA-2132295", "R-GGA-2022377", "R-HSA-77387", "R-HSA-977225", "R-CEL-6798695", "R-SCE-6798695", "R-CFA-77387", "R-CFA-1442490", "R-CEL-2132295", "R-CFA-2022377", "R-CFA-5683826", "R-PFA-2132295", "R-MMU-2132295", "R-CFA-2132295", "R-HSA-9018519", "R-HSA-1442490", "R-MMU-5683826", "R-MMU-2022377", "R-DDI-6798695", "R-DDI-5683826", "R-MMU-77387", "R-RNO-2132295", "R-RNO-2022377", "R-GGA-77387", "R-GGA-1442490", "R-HSA-2022377", "R-CEL-5683826", "R-RNO-1442490", "R-RNO-77387", "R-GGA-6798695", "R-GGA-2132295", "R-HSA-5683826", "R-PFA-6798695", "R-SCE-2132295", "R-MMU-6798695", "R-CEL-1442490", "R-CFA-6798695", "R-SSC-5683826", "R-MMU-1442490", "R-RNO-6798695", "R-DDI-2132295"], "pathways": ["R-SPO-2132295:r:MHC class II antigen presentation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-GGA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-977225:r:Amyloid fiber formation", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-CFA-77387:r:Insulin receptor recycling", "R-CFA-1442490:r:Collagen degradation", "R-CEL-2132295:r:MHC class II antigen presentation", "R-CFA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CFA-5683826:r:Surfactant metabolism", "R-PFA-2132295:r:MHC class II antigen presentation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-CFA-2132295:r:MHC class II antigen presentation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-1442490:r:Collagen degradation", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-5683826:r:Surfactant metabolism", "R-MMU-77387:r:Insulin receptor recycling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-GGA-77387:r:Insulin receptor recycling", "R-GGA-1442490:r:Collagen degradation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CEL-5683826:r:Surfactant metabolism", "R-RNO-1442490:r:Collagen degradation", "R-RNO-77387:r:Insulin receptor recycling", "R-GGA-6798695:r:Neutrophil degranulation", "R-GGA-2132295:r:MHC class II antigen presentation", "R-HSA-5683826:r:Surfactant metabolism", "R-PFA-6798695:r:Neutrophil degranulation", "R-SCE-2132295:r:MHC class II antigen presentation", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-1442490:r:Collagen degradation", "R-CFA-6798695:r:Neutrophil degranulation", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-1442490:r:Collagen degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-2132295:r:MHC class II antigen presentation"], "type": "Domain"}, "IPR033122": {"description": "LETM1-like, ribosome-binding domain", "go_ids": ["GO:0043022"], "go_terms": ["GO:0043022:ribosome binding:F"], "name": "LETM1-like_RBD", "pathway_ids": ["R-MMU-9013408", "R-RNO-9013408", "R-HSA-9013408", "R-HSA-8949215", "R-XTR-9013408", "R-HSA-9865881", "R-DRE-9013408"], "pathways": ["R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-XTR-9013408:r:RHOG GTPase cycle", "R-HSA-9865881:r:Complex III assembly", "R-DRE-9013408:r:RHOG GTPase cycle"], "type": "Domain"}, "IPR033123": {"description": "Glycosyl hydrolase 11 domain", "go_ids": [], "go_terms": [], "name": "GH11_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033144": {"description": "Cathepsin D", "go_ids": ["GO:0005764", "GO:0006508", "GO:0004190"], "go_terms": ["GO:0005764:lysosome:C", "GO:0006508:proteolysis:P", "GO:0004190:aspartic-type endopeptidase activity:F"], "name": "Cathepsin_D", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-MMU-77387", "R-HSA-2132295", "R-GGA-2022377", "R-RNO-2132295", "R-HSA-77387", "R-RNO-2022377", "R-CFA-77387", "R-CFA-1442490", "R-GGA-77387", "R-GGA-1442490", "R-HSA-2022377", "R-RNO-1442490", "R-RNO-77387", "R-GGA-6798695", "R-CFA-2022377", "R-GGA-2132295", "R-MMU-2132295", "R-MMU-6798695", "R-CFA-2132295", "R-CFA-6798695", "R-MMU-1442490", "R-HSA-9018519", "R-HSA-1442490", "R-MMU-2022377"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-2132295:r:MHC class II antigen presentation", "R-GGA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CFA-77387:r:Insulin receptor recycling", "R-CFA-1442490:r:Collagen degradation", "R-GGA-77387:r:Insulin receptor recycling", "R-GGA-1442490:r:Collagen degradation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-1442490:r:Collagen degradation", "R-RNO-77387:r:Insulin receptor recycling", "R-GGA-6798695:r:Neutrophil degranulation", "R-CFA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-GGA-2132295:r:MHC class II antigen presentation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-2132295:r:MHC class II antigen presentation", "R-CFA-6798695:r:Neutrophil degranulation", "R-MMU-1442490:r:Collagen degradation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-1442490:r:Collagen degradation", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Family"}, "IPR033162": {"description": "Tubulin-folding cofactor D", "go_ids": ["GO:0048487", "GO:0007021", "GO:0007023", "GO:0005096"], "go_terms": ["GO:0048487:beta-tubulin binding:F", "GO:0007021:tubulin complex assembly:P", "GO:0007023:post-chaperonin tubulin folding pathway:P", "GO:0005096:GTPase activator activity:F"], "name": "TBCD", "pathway_ids": ["R-HSA-389977"], "pathways": ["R-HSA-389977:r:Post-chaperonin tubulin folding pathway"], "type": "Family"}, "IPR033167": {"description": "Archaeal Nre", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "Nre", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033175": {"description": "Phosphatidylserine decarboxylase, prokaryotes", "go_ids": [], "go_terms": [], "name": "PSD-A", "pathway_ids": ["PWY-5669"], "pathways": ["PWY-5669:t:phosphatidylserine and phosphatidylethanolamine biosynthesis I"], "type": "Family"}, "IPR033177": {"description": "Phosphatidylserine decarboxylase, bacterial/eukaryotic", "go_ids": ["GO:0004609", "GO:0008654"], "go_terms": ["GO:0004609:phosphatidylserine decarboxylase activity:F", "GO:0008654:phospholipid biosynthetic process:P"], "name": "PSD-B", "pathway_ids": ["PWY-5669", "R-HSA-1483213"], "pathways": ["PWY-5669:t:phosphatidylserine and phosphatidylethanolamine biosynthesis I", "R-HSA-1483213:r:Synthesis of PE"], "type": "Family"}, "IPR033181": {"description": "MICOS subunit Mic26, fungi", "go_ids": ["GO:0061617", "GO:0042407"], "go_terms": ["GO:0061617:MICOS complex:C", "GO:0042407:cristae formation:P"], "name": "Mic26_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033182": {"description": "MICOS complex subunit MIC26/MIC27, animal", "go_ids": ["GO:0061617", "GO:0042407"], "go_terms": ["GO:0061617:MICOS complex:C", "GO:0042407:cristae formation:P"], "name": "MIC26/MIC27_animal", "pathway_ids": ["R-HSA-114608", "R-CEL-114608", "R-BTA-114608", "R-HSA-8949613", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-8949613:r:Cristae formation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR033184": {"description": "Protein PRRC2", "go_ids": [], "go_terms": [], "name": "PRRC2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033186": {"description": "Helicase HerA-like C-terminal", "go_ids": [], "go_terms": [], "name": "HerA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033192": {"description": "Outer dynein arm-docking complex subunit 3", "go_ids": ["GO:0036158", "GO:0003341", "GO:0005929"], "go_terms": ["GO:0036158:outer dynein arm assembly:P", "GO:0003341:cilium movement:P", "GO:0005929:cilium:C"], "name": "ODAD3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033194": {"description": "Microfibrillar-associated protein 1", "go_ids": [], "go_terms": [], "name": "MFAP1", "pathway_ids": ["R-HSA-72163", "R-DME-72163", "R-CEL-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR033195": {"description": "Glycine/inosamine-phosphate amidinotransferase-like", "go_ids": ["GO:0015067"], "go_terms": ["GO:0015067:amidinotransferase activity:F"], "name": "AmidinoTrfase", "pathway_ids": ["R-BTA-71288", "R-MMU-71288", "R-DRE-71288", "R-HSA-71288", "R-SSC-71288", "R-RNO-71288", "R-XTR-71288"], "pathways": ["R-BTA-71288:r:Creatine metabolism", "R-MMU-71288:r:Creatine metabolism", "R-DRE-71288:r:Creatine metabolism", "R-HSA-71288:r:Creatine metabolism", "R-SSC-71288:r:Creatine metabolism", "R-RNO-71288:r:Creatine metabolism", "R-XTR-71288:r:Creatine metabolism"], "type": "Family"}, "IPR033199": {"description": "Dimethylarginine dimethylaminohydrolase-like", "go_ids": [], "go_terms": [], "name": "DDAH-like", "pathway_ids": ["R-BTA-203615", "R-MMU-203615", "R-HSA-203615", "R-RNO-203615"], "pathways": ["R-BTA-203615:r:eNOS activation", "R-MMU-203615:r:eNOS activation", "R-HSA-203615:r:eNOS activation", "R-RNO-203615:r:eNOS activation"], "type": "Family"}, "IPR033200": {"description": "Trichohyalin", "go_ids": ["GO:0045109"], "go_terms": ["GO:0045109:intermediate filament organization:P"], "name": "TCHH", "pathway_ids": ["R-HSA-6809371"], "pathways": ["R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Family"}, "IPR033205": {"description": "COP9 signalosome, subunit CSN8", "go_ids": ["GO:0000338", "GO:0008180", "GO:0010387"], "go_terms": ["GO:0000338:protein deneddylation:P", "GO:0008180:COP9 signalosome:C", "GO:0010387:COP9 signalosome assembly:P"], "name": "COP9_CSN8", "pathway_ids": ["R-RNO-6781823", "R-DME-8856825", "R-DRE-8856825", "R-RNO-8856825", "R-MMU-8856825", "R-DME-6781823", "R-HSA-8951664", "R-DME-8951664", "R-DRE-8951664", "R-DDI-6781823", "R-DRE-5696394", "R-DME-5696394", "R-DDI-8951664", "R-RNO-5696394", "R-HSA-6781823", "R-MMU-8951664", "R-DDI-8856825", "R-MMU-6781823", "R-DDI-5696394", "R-HSA-8856825", "R-RNO-8951664", "R-HSA-5696394", "R-MMU-5696394", "R-DRE-6781823"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-8951664:r:Neddylation", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8951664:r:Neddylation", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex"], "type": "Family"}, "IPR033207": {"description": "Centriolar coiled-coil protein of 110kDa", "go_ids": ["GO:0007099", "GO:0032465", "GO:0051298", "GO:0005814"], "go_terms": ["GO:0007099:centriole replication:P", "GO:0032465:regulation of cytokinesis:P", "GO:0051298:centrosome duplication:P", "GO:0005814:centriole:C"], "name": "CCP110", "pathway_ids": ["R-HSA-380320", "R-MMU-5689880", "R-MMU-380259", "R-MMU-2565942", "R-HSA-5689880", "R-MMU-8854518", "R-HSA-380284", "R-MMU-380270", "R-MMU-9013424", "R-MMU-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-9013424", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR033214": {"description": "A-kinase-interacting protein 1", "go_ids": ["GO:1901222"], "go_terms": ["GO:1901222:regulation of non-canonical NF-kappaB signal transduction:P"], "name": "AKIP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033222": {"description": "PLAC1 family", "go_ids": [], "go_terms": [], "name": "PLAC1_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033223": {"description": "TPA-induced transmembrane protein", "go_ids": [], "go_terms": [], "name": "TTMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033227": {"description": "Calcium-dependent secretion activator", "go_ids": ["GO:0016079", "GO:1990504"], "go_terms": ["GO:0016079:synaptic vesicle exocytosis:P", "GO:1990504:dense core granule exocytosis:P"], "name": "CAPS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033228": {"description": "Protein SZT2", "go_ids": ["GO:0005777"], "go_terms": ["GO:0005777:peroxisome:C"], "name": "SZT2", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR033231": {"description": "Secreted and transmembrane protein 1", "go_ids": ["GO:0006955", "GO:0005125"], "go_terms": ["GO:0006955:immune response:P", "GO:0005125:cytokine activity:F"], "name": "SECTM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033237": {"description": "BMP/retinoic acid-inducible neural-specific protein", "go_ids": ["GO:0045930", "GO:0045666"], "go_terms": ["GO:0045930:negative regulation of mitotic cell cycle:P", "GO:0045666:positive regulation of neuron differentiation:P"], "name": "BRINP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033238": {"description": "B-cell lymphoma/leukemia 10/E10", "go_ids": ["GO:0006915"], "go_terms": ["GO:0006915:apoptotic process:P"], "name": "BCL10/E10", "pathway_ids": ["R-HSA-8866654", "R-HSA-2871837", "R-MMU-8866654", "R-HSA-1169091", "R-RNO-5607764", "R-MMU-2871837", "R-MMU-5607764", "R-RNO-1169091", "R-MMU-202424", "R-RNO-202424", "R-MMU-1169091", "R-HSA-202424", "R-HSA-5607764", "R-RNO-8866654", "R-RNO-2871837"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Family"}, "IPR033239": {"description": "Protein EVI2B", "go_ids": 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"R-DRE-5689880", "R-BTA-5689880", "R-BTA-5696394", "R-HSA-8951664", "R-HSA-5689880", "R-DRE-8951664", "R-DRE-5696400", "R-GGA-8951664", "R-GGA-5696394", "R-XTR-8951664", "R-HSA-6796648", "R-DRE-5696394", "R-XTR-5696394", "R-GGA-5696395", "R-DRE-5696395", "R-GGA-5689880", "R-XTR-5696395", "R-MMU-8951664", "R-MMU-5689880", "R-MMU-5696395", "R-HSA-5696395", "R-HSA-5696394", "R-HSA-5696400", "R-MMU-5696394", "R-BTA-5696395", "R-BTA-5696400", "R-GGA-5696400", "R-XTR-5689880", "R-MMU-5696400"], "pathways": ["R-BTA-8951664:r:Neddylation", "R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-8951664:r:Neddylation", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-GGA-8951664:r:Neddylation", "R-GGA-5696394:r:DNA Damage Recognition in GG-NER", "R-XTR-8951664:r:Neddylation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-XTR-5696394:r:DNA Damage Recognition in GG-NER", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-GGA-5689880:r:Ub-specific processing proteases", "R-XTR-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-XTR-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER"], "type": "Family"}, "IPR033315": {"description": "Fanconi-associated nuclease 1-like", "go_ids": ["GO:0036297", "GO:0004518"], "go_terms": ["GO:0036297:interstrand cross-link repair:P", "GO:0004518:nuclease activity:F"], "name": "Fan1-like", "pathway_ids": ["R-MMU-6783310", "R-HSA-6783310", "R-DRE-6783310"], "pathways": ["R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR033316": {"description": "DNA endonuclease RBBP8-like", "go_ids": [], "go_terms": [], "name": "RBBP8-like", "pathway_ids": ["R-DRE-5693607", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5685939", "R-MMU-6804756", "R-DRE-5685939", "R-MMU-5693616", "R-HSA-8953750", "R-MMU-5685938", "R-MMU-69473", "R-DRE-5693568", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-5685938", "R-HSA-912446", "R-MMU-5685939", "R-RNO-6804756", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-RNO-5693579", "R-HSA-69473", "R-RNO-5693607", "R-MMU-5685942", "R-DRE-5685942", "R-HSA-9709603", "R-HSA-5685939", "R-RNO-69473", "R-RNO-5685942", "R-HSA-6804756", "R-DRE-69473", "R-HSA-9704331", "R-RNO-5693568", "R-DRE-5693616", "R-RNO-5693616", "R-HSA-5693554", "R-HSA-5693579", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Family"}, "IPR033326": {"description": "E3 ubiquitin-protein ligase BAH1", "go_ids": [], "go_terms": [], "name": "BAH1", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR033331": {"description": "Transmembrane protein 127", "go_ids": ["GO:0008285", "GO:0032007"], "go_terms": ["GO:0008285:negative regulation of cell population proliferation:P", "GO:0032007:negative regulation of TOR signaling:P"], "name": "TMEM127", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033332": {"description": "BTG family", "go_ids": [], "go_terms": [], "name": "BTG", "pathway_ids": ["R-MMU-6804115", "R-DDI-6804115", "R-HSA-6804115", "R-HSA-9617828", "R-HSA-9820841", "R-RNO-6804115"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DDI-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Family"}, "IPR033333": {"description": "Fanconi anemia group B protein", "go_ids": ["GO:0036297", "GO:0043240"], "go_terms": ["GO:0036297:interstrand cross-link repair:P", "GO:0043240:Fanconi anaemia nuclear complex:C"], "name": "FANCB", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR033334": {"description": "Protein LONGIFOLIA 1/2", "go_ids": ["GO:0051513"], "go_terms": ["GO:0051513:regulation of monopolar cell growth:P"], "name": "LNG1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033335": {"description": "Microtubule-associated protein Jupiter", "go_ids": [], "go_terms": [], "name": "JUPITER", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033336": {"description": "Stabilizer of axonemal microtubules 1/2", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "SAXO1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033337": {"description": "MT-associated protein TORTIFOLIA1/SINE1-2", "go_ids": ["GO:0008017", "GO:0005874"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0005874:microtubule:C"], "name": "TORTIFOLIA1/SINE1-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033338": {"description": "Spc105/Spc7", "go_ids": [], "go_terms": [], "name": "Spc105/Spc7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033341": {"description": "Spindle and kinetochore-associated protein 3", "go_ids": ["GO:0007059", "GO:0000940"], "go_terms": ["GO:0007059:chromosome segregation:P", "GO:0000940:outer kinetochore:C"], "name": "SKA3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033344": {"description": "Protein CURVATURE THYLAKOID 1", "go_ids": ["GO:0009579"], "go_terms": ["GO:0009579:thylakoid:C"], "name": "CURT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033347": {"description": "Di19", "go_ids": [], "go_terms": [], "name": "Di19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033349": {"description": "ATR-interacting protein", "go_ids": ["GO:0000077"], "go_terms": ["GO:0000077:DNA damage checkpoint signaling:P"], "name": "ATRIP", "pathway_ids": ["R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-5693616", "R-HSA-69473", "R-MMU-176187", "R-DME-69473", "R-HSA-5685938", "R-MMU-6804756", "R-HSA-6783310", "R-HSA-176187", "R-MMU-5685938", "R-MMU-5693607", "R-DME-176187", "R-MMU-6783310"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-DME-69473:r:G2/M DNA damage checkpoint", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR033351": {"description": "Centrosomal protein POC5", "go_ids": [], "go_terms": [], "name": "POC5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033355": {"description": "Transmembrane protein 88", "go_ids": [], "go_terms": [], "name": "TMEM88", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033362": {"description": "SSNA1 family", "go_ids": [], "go_terms": [], "name": "SSNA1_fam", "pathway_ids": ["R-MMU-380259", "R-HSA-380284", "R-MMU-380270", "R-HSA-380270", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-BTA-380259", "R-HSA-2565942", "R-HSA-380320", "R-BTA-380270", "R-BTA-2565942", "R-BTA-8854518", "R-BTA-5620912", "R-BTA-380320", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-BTA-380284"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome"], "type": "Family"}, "IPR033367": {"description": "BRI3-binding protein", "go_ids": ["GO:0005739"], "go_terms": ["GO:0005739:mitochondrion:C"], "name": "BRI3BP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033369": {"description": "Protein C19orf12", "go_ids": [], "go_terms": [], "name": "C19orf12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033370": {"description": "Conserved oligomeric Golgi complex subunit 1", "go_ids": ["GO:0006891", "GO:0017119"], "go_terms": ["GO:0006891:intra-Golgi vesicle-mediated transport:P", "GO:0017119:COG complex:C"], "name": "COG1", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-HSA-6807878", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-HSA-9918481", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Family"}, "IPR033371": {"description": "Arginine and glutamate-rich protein 1", "go_ids": [], "go_terms": [], "name": "ARGLU1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033373": {"description": "Small kinetochore-associated protein", "go_ids": ["GO:0000776", "GO:0007051", "GO:0007059", "GO:0051988"], "go_terms": ["GO:0000776:kinetochore:C", "GO:0007051:spindle organization:P", "GO:0007059:chromosome segregation:P", "GO:0051988:regulation of attachment of spindle microtubules to kinetochore:P"], "name": "SKAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033374": {"description": "NMDA receptor synaptonuclear signalling and neuronal migration factor", "go_ids": ["GO:0048168", "GO:2001222"], "go_terms": ["GO:0048168:regulation of neuronal synaptic plasticity:P", "GO:2001222:regulation of neuron migration:P"], "name": "NSMF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033375": {"description": "CGG triplet repeat-binding protein 1", "go_ids": ["GO:0003690", "GO:0005634", "GO:0006357"], "go_terms": ["GO:0003690:double-stranded DNA binding:F", "GO:0005634:nucleus:C", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "Cggbp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033378": {"description": "Protein BRICK1", "go_ids": ["GO:0007015", "GO:0044877", "GO:0031209"], "go_terms": ["GO:0007015:actin filament organization:P", "GO:0044877:protein-containing complex binding:F", "GO:0031209:SCAR complex:C"], "name": "BRICK1", "pathway_ids": ["R-DDI-2029482", "R-HSA-5663213", "R-DRE-5663213", "R-DRE-2029482", "R-DDI-5663213", "R-DRE-9013404", "R-HSA-2029482", "R-MMU-9013404", "R-MMU-4420097", "R-MMU-2029482", "R-DDI-9013149", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-4420097", "R-MMU-5663213", "R-MMU-9013149", "R-DRE-9013149", "R-DDI-9013423", "R-DDI-9013404", "R-HSA-9664422", "R-DRE-9013423"], "pathways": ["R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DRE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DRE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR033388": {"description": "SWI/SNF-like complex subunit BAF250, C-terminal", "go_ids": [], "go_terms": [], "name": "BAF250_C", "pathway_ids": ["R-DME-8939243", "R-DME-9933946", "R-MMU-9933946", "R-MMU-9934037", "R-MMU-9933937", "R-DME-9934037", "R-HSA-9764790", "R-HSA-3214858", "R-HSA-9934037", "R-HSA-9824585", "R-MMU-3214858", "R-MMU-8939243", "R-HSA-8939243", "R-DME-3214858", "R-HSA-9845323", "R-HSA-9933937", "R-DME-9933937", "R-HSA-9933946"], "pathways": ["R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-3214858:r:RMTs methylate histone arginines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex"], "type": "Domain"}, "IPR033389": {"description": "AUX/IAA domain", "go_ids": [], "go_terms": [], "name": "AUX/IAA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033390": {"description": "3'-5' exoribonuclease Rv2179c-like domain", "go_ids": [], "go_terms": [], "name": "Rv2179c-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033391": {"description": "Fructose-1-6-bisphosphatase class I, N-terminal", "go_ids": [], "go_terms": [], "name": "FBPase_N", "pathway_ids": ["PWY-5484", "R-HSA-70263", "R-BTA-70263", "R-SSC-70263", "R-SPO-70263", "R-SCE-70263", "R-MMU-70263", "R-DDI-70263", "R-RNO-70263"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-HSA-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SSC-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Domain"}, 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{"description": "Alpha-L-rhamnosidase RhaM", "go_ids": [], "go_terms": [], "name": "RhaM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033401": {"description": "Domain of unknown function DUF5108", "go_ids": [], "go_terms": [], "name": "DUF5108", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033403": {"description": "Domain of unknown function DUF5110", "go_ids": [], "go_terms": [], "name": "DUF5110", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033404": {"description": "Domain of unknown function DUF5111", "go_ids": [], "go_terms": [], "name": "DUF5111", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033405": {"description": "Domain of unknown function DUF5112", "go_ids": [], "go_terms": [], "name": "DUF5112", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033406": {"description": "Domain of unknown function DUF5113", "go_ids": [], "go_terms": [], "name": "DUF5113", "pathway_ids": [], "pathways": [], "type": "Domain"}, 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"Gammaproteobacterial periplasmic sensor domain GAPES2", "go_ids": [], "go_terms": [], "name": "GAPES2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033423": {"description": "Gammaproteobacterial periplasmic sensor domain GAPES4", "go_ids": [], "go_terms": [], "name": "GAPES4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033424": {"description": "Membrane-associated sensor domain", "go_ids": [], "go_terms": [], "name": "MASE4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033425": {"description": "Membrane-associated sensor domain MASE3", "go_ids": [], "go_terms": [], "name": "MASE3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033426": {"description": "Domain of unknown function DUF5124", "go_ids": [], "go_terms": [], "name": "DUF5124", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033427": {"description": "Domain of unknown function DUF5123", "go_ids": [], "go_terms": [], "name": "DUF5123", "pathway_ids": [], 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"GtaA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033434": {"description": "MucB/RseB, N-terminal", "go_ids": [], "go_terms": [], "name": "MucB/RseB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033435": {"description": "Domain of unknown function DUF5129", "go_ids": [], "go_terms": [], "name": "DUF5129", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033436": {"description": "MucB/RseB, C-terminal", "go_ids": [], "go_terms": [], "name": "MucB/RseB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033437": {"description": "Protein of unknown function DUF5130", "go_ids": [], "go_terms": [], "name": "DUF5130", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033438": {"description": "Modulator of levamisole receptor-1", "go_ids": ["GO:0005892"], "go_terms": ["GO:0005892:acetylcholine-gated channel complex:C"], "name": "MOLO1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033439": {"description": "Chromosome 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"GH30_C", "pathway_ids": ["R-HSA-390471", "R-CEL-9840310", "R-MMU-9840310", "R-HSA-9840310"], "pathways": ["R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Domain"}, "IPR033453": {"description": "Glycosyl hydrolase family 30, TIM-barrel domain", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_30_TIM-barrel", "pathway_ids": ["R-HSA-390471", "R-CEL-9840310", "R-MMU-9840310", "R-HSA-9840310"], "pathways": ["R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Domain"}, "IPR033454": {"description": "RecG, wedge domain", "go_ids": [], "go_terms": [], "name": "RecG_wedge", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033455": {"description": "Transcriptional regulator AbiEi antitoxin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AbiEi_3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033456": {"description": "Protein of unknown function DUF5132", "go_ids": [], "go_terms": [], "name": "DUF5132", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033457": {"description": "Protein of unknown function DUF5133", "go_ids": [], "go_terms": [], "name": "DUF5133", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033458": {"description": "Protein of unknown function DUF5134", "go_ids": [], "go_terms": [], "name": "DUF5134", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033459": {"description": "Spirocyclase AveC-like", "go_ids": [], "go_terms": [], "name": "AveC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033461": {"description": "Putative WW-binding domain and destruction box", "go_ids": [], "go_terms": [], "name": "WRNPLPNID", "pathway_ids": ["R-MMU-6791226", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR033462": {"description": "Cache 3/Cache 2 fusion domain", "go_ids": [], "go_terms": [], "name": "Cache_3-Cache_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033463": {"description": "Single cache domain 3", "go_ids": [], "go_terms": [], "name": "sCache_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033464": {"description": "CSN8/PSMD8/EIF3K", "go_ids": [], "go_terms": [], "name": "CSN8_PSD8_EIF3K", "pathway_ids": ["R-RNO-6781823", "R-MMU-450408", "R-HSA-9020702", "R-HSA-174178", "R-HSA-9604323", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-HSA-8951664", "R-HSA-9010553", "R-MMU-174154", "R-MMU-69017", "R-HSA-75815", "R-CEL-8941858", "R-CEL-195253", "R-MMU-9020702", "R-MMU-8948751", "R-MMU-69481", "R-DME-5696394", "R-HSA-72695", "R-SPO-5689880", "R-DDI-8856825", "R-MMU-5689880", "R-MMU-75815", "R-CEL-1234176", "R-DDI-9929491", "R-MMU-5668541", "R-HSA-8854050", "R-MMU-5696394", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-HSA-1234176", "R-HSA-9931269", "R-DDI-174084", "R-HSA-5607761", "R-HSA-9929491", "R-MMU-68867", "R-MMU-9932298", "R-BTA-72702", "R-HSA-72706", "R-HSA-72702", "R-MMU-1234176", "R-RNO-5696394", "R-MMU-4641258", "R-DDI-4641258", "R-DDI-5696394", "R-RNO-8951664", "R-HSA-5696394", "R-HSA-180534", "R-CEL-72649", "R-HSA-1236974", "R-CEL-8948751", "R-CEL-4608870", "R-MMU-5687128", "R-DME-72702", "R-MMU-9766229", "R-DDI-187577", "R-HSA-174154", "R-DDI-72689", "R-CEL-72689", "R-DDI-382556", "R-HSA-68949", "R-HSA-5610785", "R-MMU-187577", "R-HSA-2467813", "R-MMU-8852276", "R-MMU-72689", "R-MMU-68949", "R-DME-72649", "R-CEL-9907900", "R-HSA-156827", "R-XTR-72702", "R-HSA-9824272", "R-DDI-174178", "R-CEL-983168", "R-MMU-174178", "R-MMU-349425", "R-MMU-8939236", "R-CEL-8854050", "R-HSA-9907900", "R-MMU-6781823", "R-DDI-69601", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-MMU-9762114", "R-HSA-9762114", "R-DRE-6781823", "R-DDI-5689880", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-MMU-72695", "R-MMU-382556", "R-HSA-5610780", "R-DDI-5687128", "R-CEL-9755511", "R-DDI-9907900", "R-SCE-1236978", "R-DME-72689", "R-MMU-1169091", "R-HSA-72649", "R-MMU-5607761", "R-MMU-156827", "R-MMU-5676590", "R-HSA-8939902", "R-CEL-5689880", "R-MMU-174184", "R-DRE-72702", "R-MMU-8939902", "R-HSA-8856825", "R-DDI-156827", "R-CEL-9762114", "R-HSA-8939236", "R-SPO-350562", "R-CEL-8951664", "R-HSA-5358346", "R-DDI-8854050", "R-MMU-5632684", "R-SPO-9907900", "R-MMU-5607764", "R-DME-6781823", "R-MMU-2467813", "R-DME-8951664", "R-HSA-9932298", "R-DRE-8951664", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-DDI-1236978", "R-DDI-5632684", "R-DDI-8951664", "R-BTA-72689", "R-MMU-8951664", "R-HSA-6781823", "R-MMU-72706", "R-CEL-382556", "R-CEL-5689603", "R-HSA-4641257", "R-BTA-72695", "R-HSA-174113", "R-MMU-9929491", "R-MMU-9929356", "R-SCE-5668541", "R-DDI-174154", "R-HSA-68867", "R-MMU-9907900", "R-HSA-69481", "R-BTA-156827", "R-CEL-4641258", "R-DRE-72695", "R-DDI-5658442", "R-DDI-72695", "R-DDI-8948751", "R-HSA-8941858", "R-HSA-5678895", "R-DDI-6781823", "R-HSA-9755511", "R-HSA-4641258", "R-CEL-9929491", "R-SPO-5689603", "R-DRE-5696394", "R-CEL-156827", "R-HSA-180585", "R-SPO-1236978", "R-HSA-1169091", "R-CEL-69017", "R-HSA-5658442", "R-HSA-4608870", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-HSA-5689603", "R-BTA-72649", "R-DDI-72702", "R-MMU-5610780", "R-HSA-187577", "R-DME-156827", "R-DDI-9755511", "R-MMU-8856825", "R-HSA-349425", "R-CEL-72702", "R-CEL-8939902", "R-MMU-9755511", "R-CEL-72695", "R-HSA-174184", "R-MMU-9954709", "R-DDI-75815", 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non-canonical NF-kB pathway", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-CEL-4641257:r:Degradation of AXIN"], "type": "Domain"}, "IPR033467": {"description": "Tesmin/TSO1-like CXC domain", "go_ids": [], "go_terms": [], "name": "Tesmin/TSO1-like_CXC", "pathway_ids": ["R-MMU-8953750", "R-HSA-2132295", "R-HSA-2559580", "R-HSA-69205", "R-DRE-2559580", "R-MMU-983189", "R-XTR-9764725", "R-DRE-8953750", "R-MMU-212300", "R-HSA-8953750", "R-DME-2559580", "R-MMU-1538133", "R-HSA-6811434", "R-HSA-69656", "R-HSA-3214841", "R-CEL-1538133", "R-MMU-2132295", "R-HSA-8943724", "R-DME-9764725", "R-HSA-1538133", "R-DME-8953750", "R-DRE-212300", "R-XTR-1538133", "R-DRE-9909649", "R-DRE-9764725", "R-DME-9909649", "R-BTA-212300", "R-MMU-6811434", "R-MMU-3214847", "R-RNO-1538133", "R-MMU-437239", "R-MMU-3214841", "R-DME-212300", "R-HSA-1362300", "R-XTR-212300", "R-GGA-3214847", "R-DRE-1538133", "R-HSA-437239", "R-HSA-156711", "R-HSA-9764725", "R-HSA-9609690", "R-MMU-9764725", "R-MMU-2559580", "R-DME-1538133", "R-MMU-8943724", "R-HSA-9710421", "R-XTR-8953750", "R-HSA-212300", "R-HSA-9909649", "R-XTR-9909649", "R-DME-3214847", "R-DRE-3214841", "R-MMU-9909649", "R-HSA-983189", "R-HSA-1362277", "R-XTR-2559580", "R-DME-8943724", "R-HSA-3214847", "R-HSA-69202", "R-HSA-5617472"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-69205:r:G1/S-Specific Transcription", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-983189:r:Kinesins", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-CEL-1538133:r:G0 and Early G1", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-1538133:r:G0 and Early G1", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-XTR-1538133:r:G0 and Early G1", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-3214847:r:HATs acetylate histones", "R-RNO-1538133:r:G0 and Early G1", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-GGA-3214847:r:HATs acetylate histones", "R-DRE-1538133:r:G0 and Early G1", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-DME-1538133:r:G0 and Early G1", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9710421:r:Defective pyroptosis", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DME-3214847:r:HATs acetylate histones", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-983189:r:Kinesins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "type": "Domain"}, "IPR033468": {"description": "Metaxin, glutathione S-transferase domain", "go_ids": [], "go_terms": [], "name": "Metaxin_GST", "pathway_ids": ["R-MMU-9013404", "R-SSC-9013404", "R-HSA-1268020", "R-HSA-8949613", "R-HSA-9013404"], "pathways": ["R-MMU-9013404:r:RAC2 GTPase cycle", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-8949613:r:Cristae formation", "R-HSA-9013404:r:RAC2 GTPase cycle"], "type": "Domain"}, "IPR033469": {"description": "CYTH-like domain superfamily", "go_ids": [], "go_terms": [], "name": "CYTH-like_dom_sf", "pathway_ids": ["R-RNO-196819", "R-HSA-196819", "R-MMU-196819", "R-BTA-196819"], "pathways": ["R-RNO-196819:r:Vitamin B1 (thiamin) metabolism", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Homologous_superfamily"}, "IPR033470": {"description": "Fatty acid kinase subunit A-like, C-terminal", "go_ids": [], "go_terms": [], "name": "FakA-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033471": {"description": "DIRP domain", "go_ids": [], "go_terms": [], "name": "DIRP", "pathway_ids": ["R-MMU-1538133", "R-HSA-69656", "R-CEL-1538133", "R-HSA-1362277", "R-HSA-69205", "R-HSA-1362300", "R-HSA-156711", "R-DRE-1538133", "R-HSA-1538133", "R-HSA-69202"], "pathways": ["R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-156711:r:Polo-like kinase mediated events", "R-DRE-1538133:r:G0 and Early G1", "R-HSA-1538133:r:G0 and Early G1", "R-HSA-69202:r:Cyclin E associated events during G1/S transition"], "type": "Domain"}, "IPR033473": {"description": "Atos-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Atos-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033479": {"description": "Double Cache domain 1", "go_ids": [], "go_terms": [], "name": "dCache_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033480": {"description": "Single Cache domain 2", "go_ids": [], "go_terms": [], "name": "sCache_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033481": {"description": "Cell fusion protein Dni1/Fig1", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Dni1/Fig1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033482": {"description": "BRCA2-interacting transcriptional repressor EMSY", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "EMSY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033485": {"description": "Protein EMSY-LIKE, plant", "go_ids": ["GO:0050832"], "go_terms": ["GO:0050832:defense response to fungus:P"], "name": "EMSY-LIKE_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033489": {"description": "E3 ubiquitin-protein ligase RBBP6 family", "go_ids": ["GO:0006397", "GO:0061630", "GO:0016567"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:0061630:ubiquitin protein ligase activity:F", "GO:0016567:protein ubiquitination:P"], "name": "RBBP6", "pathway_ids": ["PWY-7511", "R-SPO-9770562", "R-MMU-9013422", "R-HSA-9013422", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-983168", "R-SPO-983168", "R-SCE-983168", "R-HSA-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR033490": {"description": "Leucine-rich PPR motif-containing protein", "go_ids": [], "go_terms": [], "name": "LRP130", "pathway_ids": ["R-HSA-9937008", "R-HSA-9836573"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Family"}, "IPR033494": {"description": "NUDE family", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "NUDE", "pathway_ids": ["R-GGA-380284", "R-MMU-2467813", "R-GGA-2565942", "R-HSA-380284", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-XTR-141444", "R-HSA-380320", "R-GGA-9648025", "R-RNO-380284", "R-GGA-5663220", "R-DRE-5663220", "R-MMU-5620912", "R-MMU-141444", "R-MMU-380259", "R-MMU-380270", "R-HSA-141444", "R-HSA-9648025", "R-GGA-5620912", "R-RNO-5663220", "R-XTR-380320", "R-XTR-380259", "R-GGA-141444", "R-MMU-8854518", "R-RNO-2467813", "R-GGA-8854518", "R-RNO-380270", "R-MMU-5663220", "R-RNO-141444", "R-HSA-2467813", "R-RNO-2500257", "R-XTR-2467813", "R-XTR-380270", "R-RNO-5620912", "R-MMU-380284", "R-GGA-2500257", "R-HSA-2565942", "R-XTR-5620912", "R-RNO-2565942", "R-HSA-68877", "R-GGA-2467813", "R-MMU-9648025", "R-HSA-5620912", "R-GGA-380259", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-HSA-2500257", "R-RNO-8854518", "R-DRE-2500257", "R-XTR-5663220", "R-XTR-380284", "R-GGA-380320", "R-HSA-380270", "R-XTR-68877", "R-RNO-380259", "R-XTR-2565942", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259", "R-XTR-8854518", "R-XTR-2500257", "R-GGA-380270"], "pathways": ["R-GGA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-GGA-8854518:r:AURKA Activation by TPX2", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-68877:r:Mitotic Prometaphase", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Family"}, "IPR033504": {"description": "Agglutinin-like protein", "go_ids": ["GO:0007155"], "go_terms": ["GO:0007155:cell adhesion:P"], "name": "ALS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033505": {"description": "USPL1 peptidase", "go_ids": ["GO:0032183", "GO:0030576"], "go_terms": ["GO:0032183:SUMO binding:F", "GO:0030576:Cajal body organization:P"], "name": "USPL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033509": {"description": "E3 ubiquitin-protein ligase RNF146", "go_ids": ["GO:0061630", "GO:0016055", "GO:0072572"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0016055:Wnt signaling pathway:P", "GO:0072572:poly-ADP-D-ribose binding:F"], "name": "RNF146", "pathway_ids": ["PWY-7511", "R-RNO-201681", "R-MMU-5689880", "R-BTA-8948751", "R-HSA-201681", "R-RNO-8948751", "R-RNO-4641257", "R-DRE-8948751", "R-MMU-4641257", "R-BTA-5689880", "R-HSA-4641257", "R-HSA-5689880", "R-HSA-8948751", "R-BTA-4641257", "R-MMU-201681", "R-MMU-8948751", "R-BTA-201681", "R-XTR-8948751", "R-RNO-5689880"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-RNO-4641257:r:Degradation of AXIN", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-4641257:r:Degradation of AXIN", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-XTR-8948751:r:Regulation of PTEN stability and activity", "R-RNO-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR033512": {"description": "Protein TFG", "go_ids": ["GO:0048208", "GO:0042802", "GO:0006888"], "go_terms": ["GO:0048208:COPII vesicle coat assembly:P", "GO:0042802:identical protein binding:F", "GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P"], "name": "TFG", "pathway_ids": ["R-HSA-204005", "R-HSA-9725370", "R-CEL-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-CEL-204005:r:COPII-mediated vesicle transport"], "type": "Family"}, "IPR033522": {"description": "Receptor-type tyrosine-protein phosphatase-like N/N2", "go_ids": ["GO:0030141"], "go_terms": ["GO:0030141:secretory granule:C"], "name": "IA-2/IA-2_beta", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR033529": {"description": "Mucin-7", "go_ids": [], "go_terms": [], "name": "MUC7", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-913709", "R-HSA-977068", "R-HSA-5083625"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC"], "type": "Family"}, "IPR033533": {"description": "Proline-rich protein 27", "go_ids": [], "go_terms": [], "name": "PRR27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033536": {"description": "Spermatogenesis-associated protein 22", "go_ids": ["GO:0000711", "GO:0007129", "GO:0007276"], "go_terms": ["GO:0000711:meiotic DNA repair synthesis:P", "GO:0007129:homologous chromosome pairing at meiosis:P", "GO:0007276:gamete generation:P"], "name": "Spata22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033537": {"description": "Stimulated by retinoic acid gene 8 protein", "go_ids": ["GO:0051321", "GO:0071300"], "go_terms": ["GO:0051321:meiotic cell cycle:P", "GO:0071300:cellular response to retinoic acid:P"], "name": "Stra8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033539": {"description": "Retroviral-like aspartic protease 1", "go_ids": ["GO:0004190", "GO:0016020"], "go_terms": ["GO:0004190:aspartic-type endopeptidase activity:F", "GO:0016020:membrane:C"], "name": "Asprv1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033540": {"description": "MALT1, immunoglobulin-like domain superfamily", "go_ids": [], "go_terms": [], "name": "MALT1_IG-like_dom_sf", "pathway_ids": ["R-HSA-2871837", "R-HSA-1169091", "R-MMU-202424", "R-MMU-2871837", "R-MMU-5607764", "R-HSA-5660668", "R-MMU-1169091", "R-HSA-202424", "R-HSA-5607764", "R-MMU-5660668"], "pathways": ["R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-5660668:r:CLEC7A/inflammasome pathway"], "type": "Homologous_superfamily"}, "IPR033541": {"description": "Dermokine", "go_ids": ["GO:1903575"], "go_terms": ["GO:1903575:cornified envelope assembly:P"], "name": "Dermokine", "pathway_ids": ["R-HSA-9725554"], "pathways": ["R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin"], "type": "Family"}, "IPR033542": {"description": "Transmembrane protein 225", "go_ids": ["GO:0010923"], "go_terms": ["GO:0010923:negative regulation of phosphatase activity:P"], "name": "TM225", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033543": {"description": "Bcl-2-like protein 15", "go_ids": [], "go_terms": [], "name": "BCL2L15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033544": {"description": "Nuclear receptor subfamily 0 group B member 1/2", "go_ids": [], "go_terms": [], "name": "NR0B1/2", "pathway_ids": ["R-MMU-383280", "R-RNO-383280", "R-HSA-383280"], "pathways": ["R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-HSA-383280:r:Nuclear Receptor transcription pathway"], "type": "Family"}, "IPR033545": {"description": "Centrosomal protein of 89kDa", "go_ids": ["GO:0060271", "GO:0007268", "GO:0005814", "GO:0007005"], "go_terms": ["GO:0060271:cilium assembly:P", "GO:0007268:chemical synaptic transmission:P", "GO:0005814:centriole:C", "GO:0007005:mitochondrion organization:P"], "name": "CEP89", "pathway_ids": ["R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR033549": {"description": "NFAT activation molecule 1", "go_ids": ["GO:0050861", "GO:0004888", "GO:0016020", "GO:0045577", "GO:0001819"], "go_terms": ["GO:0050861:positive regulation of B cell receptor signaling pathway:P", "GO:0004888:transmembrane signaling receptor activity:F", "GO:0016020:membrane:C", "GO:0045577:regulation of B cell differentiation:P", "GO:0001819:positive regulation of cytokine production:P"], "name": "NFAM1", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR033551": {"description": "Dynein regulatory complex subunit 7", "go_ids": [], "go_terms": [], "name": "DRC7/lobo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033555": {"description": "TCF3 fusion partner", "go_ids": ["GO:0006915"], "go_terms": ["GO:0006915:apoptotic process:P"], "name": "TFPT", "pathway_ids": ["R-BTA-5689603", "R-MMU-5696394", "R-HSA-5689603", "R-MMU-5689603", "R-RNO-5689603", "R-BTA-5696394", "R-RNO-5696394", "R-HSA-5696394"], "pathways": ["R-BTA-5689603:r:UCH proteinases", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-RNO-5689603:r:UCH proteinases", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Family"}, "IPR033556": {"description": "Phospholipase A1-II", "go_ids": ["GO:0008970"], "go_terms": ["GO:0008970:glycerophospholipid phospholipase A1 activity:F"], "name": "PLA", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Family"}, "IPR033557": {"description": "Ciliary microtubule-associated protein 2", "go_ids": [], "go_terms": [], "name": "CIMAP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033558": {"description": "Intraflagellar transport protein 25", "go_ids": ["GO:0030992", "GO:0042073"], "go_terms": ["GO:0030992:intraciliary transport particle B:C", "GO:0042073:intraciliary transport:P"], "name": "IFT25", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR033561": {"description": "Fas-binding factor 1", "go_ids": ["GO:0060271", "GO:0097539", "GO:0090162"], "go_terms": ["GO:0060271:cilium assembly:P", "GO:0097539:ciliary transition fiber:C", "GO:0090162:establishment of epithelial cell polarity:P"], "name": "FBF1", "pathway_ids": ["R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR033562": {"description": "Patatin-like phospholipase domain-containing protein", "go_ids": ["GO:0016042", "GO:0016787"], "go_terms": ["GO:0016042:lipid catabolic process:P", "GO:0016787:hydrolase activity:F"], "name": "PLPL", "pathway_ids": ["PWY-6857", "R-RNO-381426", "R-HSA-381426", "R-CEL-163560", "R-MMU-1482883", "R-RNO-8957275", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-HSA-1482883", "R-MMU-163560", "R-HSA-8957275", "R-CEL-1482883", "R-RNO-1482883", "R-MMU-8957275", "R-HSA-163560", "R-HSA-9841922"], "pathways": ["PWY-6857:t:retinol biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-163560:r:Triglyceride catabolism", "R-MMU-1482883:r:Acyl chain remodeling of DAG and TAG", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1482883:r:Acyl chain remodeling of DAG and TAG", "R-MMU-163560:r:Triglyceride catabolism", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-CEL-1482883:r:Acyl chain remodeling of DAG and TAG", "R-RNO-1482883:r:Acyl chain remodeling of DAG and TAG", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-163560:r:Triglyceride catabolism", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "type": "Family"}, "IPR033570": {"description": "Sodium channel modifier 1", "go_ids": ["GO:0008380"], "go_terms": ["GO:0008380:RNA splicing:P"], "name": "SCNM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033571": {"description": "NEDD4-binding protein 3", "go_ids": [], "go_terms": [], "name": "N4BP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033575": {"description": "DET1- and DDB1-associated protein 1-like", "go_ids": ["GO:0032434"], "go_terms": ["GO:0032434:regulation of proteasomal ubiquitin-dependent protein catabolic process:P"], "name": "DDA1-like", "pathway_ids": ["R-DRE-8951664", "R-BTA-8951664", "R-HSA-8951664", "R-MMU-8951664"], "pathways": ["R-DRE-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation"], "type": "Family"}, "IPR033577": {"description": "Aminopeptidase O", "go_ids": ["GO:0070006", "GO:0005730"], "go_terms": ["GO:0070006:metalloaminopeptidase activity:F", "GO:0005730:nucleolus:C"], "name": "AOPep", "pathway_ids": ["PWY-7694", "PWY-6423", "PWY-7954"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-6423:t:hemoglobin degradation", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis"], "type": "Family"}, "IPR033579": {"description": "Transmembrane protein 128", "go_ids": [], "go_terms": [], "name": "TMEM128", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033580": {"description": "Nurim-like", "go_ids": [], "go_terms": [], "name": "Nurim-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033583": {"description": "BEN domain-containing protein 3", "go_ids": ["GO:0003677", "GO:0000183", "GO:0000792"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0000183:rDNA heterochromatin formation:P", "GO:0000792:heterochromatin:C"], "name": "BEND3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033585": {"description": 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"R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73863:r:RNA Polymerase I Transcription Termination"], "type": "Family"}, "IPR033602": {"description": "Ciliary microtubule-associated protein 3", "go_ids": [], "go_terms": [], "name": "CIMAP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033603": {"description": "Centrosomal protein of 44kDa", "go_ids": [], "go_terms": [], "name": "CEP44", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033614": {"description": "Ras association domain-containing protein 1-6", "go_ids": [], "go_terms": [], "name": "RASSF1-6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033615": {"description": "Protein EOLA1/EOLA2", "go_ids": [], "go_terms": [], "name": "EOLA1/EOLA2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033616": {"description": "Bridge-like lipid transfer protein family member 1", "go_ids": [], "go_terms": [], "name": "BLTP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033620": {"description": "Small ribosomal subunit protein mS37, metazoan", "go_ids": ["GO:0032543", "GO:0005761"], "go_terms": ["GO:0032543:mitochondrial translation:P", "GO:0005761:mitochondrial ribosome:C"], "name": "Ribosomal_mS37_met", "pathway_ids": ["R-MMU-5419276", "R-MMU-9937383", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Family"}, "IPR033621": {"description": "TRAF-interacting protein with FHA domain-containing protein", "go_ids": ["GO:0043123", "GO:0005515"], "go_terms": ["GO:0043123:positive regulation of canonical NF-kappaB signal transduction:P", "GO:0005515:protein binding:F"], "name": "TIFA", "pathway_ids": ["R-BTA-9645460", "R-MMU-445989", "R-RNO-9645460", "R-BTA-445989", "R-MMU-9645460", "R-RNO-445989", "R-XTR-9645460", "R-HSA-9645460", "R-HSA-445989"], "pathways": ["R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-XTR-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation"], "type": "Family"}, "IPR033635": {"description": "Ankyrin repeat and SAM domain-containing protein 1/Caskin", "go_ids": [], "go_terms": [], "name": "ANKS1/Caskin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033640": {"description": "Fatty acyl-CoA reductase, C-terminal", "go_ids": [], "go_terms": [], "name": "FAR_C", "pathway_ids": ["PWY-7782", "PWY-5884", "PWY-7656", "PWY-6733", "R-DME-9640463", "R-BTA-9640463", "R-HSA-9640463", "R-MMU-9640463", "R-RNO-9640463"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-5884:t:wax esters biosynthesis I", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-6733:t:sporopollenin precursors biosynthesis", "R-DME-9640463:r:Wax biosynthesis", "R-BTA-9640463:r:Wax biosynthesis", "R-HSA-9640463:r:Wax biosynthesis", "R-MMU-9640463:r:Wax biosynthesis", "R-RNO-9640463:r:Wax biosynthesis"], "type": "Domain"}, "IPR033646": {"description": "CLU central domain", "go_ids": [], "go_terms": [], "name": "CLU-central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033647": {"description": "AAR2, N-terminal", "go_ids": [], "go_terms": [], "name": "Aar2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033648": {"description": "AAR2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AAR2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033671": {"description": "tRNA (guanosine(18)-2'-O)-methyltransferase", "go_ids": ["GO:0008168", "GO:0030488"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0030488:tRNA methylation:P"], "name": "TrmH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033672": {"description": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase", "go_ids": ["GO:0016853"], "go_terms": ["GO:0016853:isomerase activity:F"], "name": "LsrG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033674": {"description": "Thioredoxin/glutathione peroxidase BtuE", "go_ids": [], "go_terms": [], "name": "BtuE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033676": {"description": "Autoinducer-2 kinase", "go_ids": ["GO:0071518", "GO:0009372"], "go_terms": ["GO:0071518:autoinducer-2 kinase activity:F", "GO:0009372:quorum sensing:P"], "name": "AI-2_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033689": {"description": "NAD-dependent formate dehydrogenase", "go_ids": ["GO:0008863"], "go_terms": ["GO:0008863:formate dehydrogenase (NAD+) activity:F"], "name": "FDH_NAD-dep", "pathway_ids": ["PWY-6696", "PWY-7985", "PWY-1881", "PWY-5497"], "pathways": ["PWY-6696:t:oxalate degradation III", "PWY-7985:t:oxalate degradation VI", "PWY-1881:t:formate oxidation to CO2", "PWY-5497:t:purine nucleobases degradation II (anaerobic)"], "type": "Family"}, "IPR033697": {"description": "Ribonuclease T2, eukaryotic", "go_ids": [], "go_terms": [], "name": "Ribonuclease_T2_eukaryotic", "pathway_ids": ["R-SCE-6798695", "R-MMU-6798695", "R-HSA-6798695", "R-DRE-6798695", "R-CEL-6798695"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR033698": {"description": "Plk4, second cryptic polo-box domain", "go_ids": [], "go_terms": [], "name": "POLO_box_Plk4_2", "pathway_ids": ["R-DRE-380320", "R-MMU-380259", "R-RNO-8854518", "R-HSA-380284", "R-MMU-380270", "R-XTR-380270", "R-XTR-380284", "R-XTR-8854518", "R-RNO-5620912", "R-HSA-380270", "R-HSA-8854518", "R-XTR-380259", "R-XTR-380320", "R-MMU-380284", "R-BTA-380259", "R-RNO-380259", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-MMU-2565942", "R-XTR-5620912", "R-MMU-380320", "R-BTA-8854518", "R-BTA-380270", "R-BTA-2565942", "R-RNO-2565942", "R-BTA-5620912", "R-RNO-380284", "R-XTR-2565942", "R-BTA-380320", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-BTA-380284", "R-RNO-380270"], "pathways": ["R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR033699": {"description": "Plk4, first cryptic polo-box domain", "go_ids": [], "go_terms": [], "name": "POLO_box_Plk4_1", "pathway_ids": ["R-DRE-380320", "R-MMU-380259", "R-RNO-8854518", "R-HSA-380284", "R-MMU-380270", "R-XTR-380270", "R-XTR-380284", "R-XTR-8854518", "R-RNO-5620912", "R-HSA-380270", "R-HSA-8854518", "R-XTR-380259", "R-XTR-380320", "R-MMU-380284", "R-BTA-380259", "R-RNO-380259", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-MMU-2565942", "R-XTR-5620912", "R-MMU-380320", "R-BTA-8854518", "R-BTA-380270", "R-BTA-2565942", "R-RNO-2565942", "R-BTA-5620912", "R-RNO-380284", "R-XTR-2565942", "R-BTA-380320", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-BTA-380284", "R-RNO-380270"], "pathways": ["R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR033715": {"description": "GDP-mannose mannosyl hydrolase", "go_ids": ["GO:0008727"], "go_terms": ["GO:0008727:GDP-mannose mannosyl hydrolase activity:F"], "name": "GDPMH", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Family"}, "IPR033741": {"description": "Sequestosome-1, UBA domain", "go_ids": [], "go_terms": [], "name": "SQSTM_UBA", "pathway_ids": ["R-HSA-9020702", "R-RNO-9664873", "R-RNO-5205685", "R-RNO-9020702", "R-HSA-209560", "R-MMU-209543", "R-HSA-209543", "R-HSA-8951664", "R-RNO-9755511", "R-RNO-209560", "R-HSA-205043", "R-MMU-209560", "R-MMU-9020702", "R-HSA-9755511", "R-MMU-9755511", "R-MMU-5205685", "R-RNO-209543", "R-DME-9755511", "R-MMU-9664873", "R-DME-5205685", "R-RNO-205043", "R-DME-9664873", "R-HSA-9759194", "R-HSA-5205685", "R-MMU-205043", "R-HSA-9725370", "R-HSA-9664873"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9664873:r:Pexophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-8951664:r:Neddylation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-MMU-9020702:r:Interleukin-1 signaling", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9664873:r:Pexophagy", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-DME-9664873:r:Pexophagy", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9664873:r:Pexophagy"], "type": "Domain"}, "IPR033742": {"description": "IQ motif and SEC7 domain-containing protein, PH domain", "go_ids": [], "go_terms": [], "name": "IQSEC_PH", "pathway_ids": ["R-HSA-9768919"], "pathways": ["R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Domain"}, "IPR033752": {"description": "MetA family", "go_ids": [], "go_terms": [], "name": "MetA_family", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033753": {"description": "Glycine cleavage system H-protein/Simiate", "go_ids": [], "go_terms": [], "name": "GCV_H/Fam206", "pathway_ids": ["R-SPO-6783984", "R-DME-6783984", "R-HSA-9857492", "R-RNO-6783984", "R-SPO-9857492", "R-MMU-6783984", "R-BTA-6783984", "R-MMU-9857492", "R-DME-9857492", "R-HSA-6783984", "R-SCE-6783984", "R-DDI-6783984", "R-RNO-9857492", "R-SCE-9857492", "R-GGA-6783984", "R-GGA-9857492", "R-BTA-9857492", "R-DDI-9857492"], "pathways": ["R-SPO-6783984:r:Glycine degradation", "R-DME-6783984:r:Glycine degradation", "R-HSA-9857492:r:Protein lipoylation", "R-RNO-6783984:r:Glycine degradation", "R-SPO-9857492:r:Protein lipoylation", "R-MMU-6783984:r:Glycine degradation", "R-BTA-6783984:r:Glycine degradation", "R-MMU-9857492:r:Protein lipoylation", "R-DME-9857492:r:Protein lipoylation", "R-HSA-6783984:r:Glycine degradation", "R-SCE-6783984:r:Glycine degradation", "R-DDI-6783984:r:Glycine degradation", "R-RNO-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-GGA-6783984:r:Glycine degradation", "R-GGA-9857492:r:Protein lipoylation", "R-BTA-9857492:r:Protein lipoylation", "R-DDI-9857492:r:Protein lipoylation"], "type": "Family"}, "IPR033755": {"description": "PdxS/SNZ N-terminal domain", "go_ids": [], "go_terms": [], "name": "PdxS/SNZ_N", "pathway_ids": ["PWY-6466"], "pathways": ["PWY-6466:t:pyridoxal 5'-phosphate biosynthesis II"], "type": "Domain"}, "IPR033756": {"description": "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35", "go_ids": [], "go_terms": [], "name": "YlxH/NBP35", "pathway_ids": ["R-DME-6799198", "R-MMU-6799198", "R-HSA-2564830", "R-DDI-6799198", "R-HSA-6799198"], "pathways": ["R-DME-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-DDI-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR033757": {"description": "Pre-mRNA-splicing regulator WTAP", "go_ids": ["GO:0016556", "GO:0000381", "GO:0005634"], "go_terms": ["GO:0016556:mRNA modification:P", "GO:0000381:regulation of alternative mRNA splicing, via spliceosome:P", "GO:0005634:nucleus:C"], "name": "WTAP", "pathway_ids": ["R-DRE-72203", "R-DME-72203", "R-HSA-72203", "R-MMU-72203"], "pathways": ["R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Family"}, "IPR033758": {"description": "pGP3 C-terminal domain", "go_ids": [], "go_terms": [], "name": "pGP3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033759": {"description": "Systemic RNA interference defective protein 5", "go_ids": ["GO:0005770", "GO:0050658", "GO:0035194"], "go_terms": ["GO:0005770:late endosome:C", "GO:0050658:RNA transport:P", "GO:0035194:regulatory ncRNA-mediated post-transcriptional gene silencing:P"], "name": "Sid-5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033760": {"description": "Integrin beta N-terminal", "go_ids": [], "go_terms": [], "name": "Integrin_beta_N", "pathway_ids": ["R-DME-2173789", "R-HSA-8874081", "R-MMU-210991", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-MMU-9013408", "R-MMU-210990", "R-CEL-3000178", "R-HSA-9856532", "R-MMU-445355", "R-CEL-1566948", "R-DME-445355", "R-MMU-3000170", "R-CEL-446343", "R-RNO-9634597", "R-RNO-210990", "R-MMU-202733", "R-CEL-198933", "R-HSA-8875513", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-446107", "R-HSA-6802955", "R-HSA-210991", "R-RNO-446343", "R-HSA-6802948", "R-RNO-1566977", "R-RNO-445144", "R-BTA-1566948", "R-DME-114608", "R-MMU-9634597", "R-CEL-5674135", "R-HSA-9609690", "R-HSA-447041", "R-DME-216083", "R-MMU-9013423", "R-HSA-2022090", "R-MMU-216083", "R-HSA-445144", "R-MMU-354192", "R-MMU-9860927", "R-MMU-446107", "R-HSA-9656223", "R-HSA-9634597", "R-MMU-5674135", "R-RNO-216083", "R-RNO-9860927", "R-HSA-9013423", "R-RNO-8874081", "R-HSA-114608", "R-MMU-8874081", "R-RNO-354192", "R-CEL-354192", "R-RNO-5674135", "R-BTA-2129379", "R-RNO-2173789", "R-CEL-9013423", "R-RNO-446107", "R-MMU-3000157", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-3000170", "R-MMU-1566977", "R-DME-6798695", "R-DME-446107", "R-MMU-354194", "R-MMU-1236973", "R-RNO-9013423", "R-CEL-445355", "R-HSA-5663220", "R-MMU-9013149", "R-RNO-3000170", "R-BTA-216083", "R-HSA-202733", "R-HSA-6798695", "R-HSA-5674135", "R-HSA-166016", "R-CEL-6798695", "R-CEL-354194", "R-BTA-6798695", "R-RNO-3000157", "R-RNO-9013149", "R-MMU-4420097", "R-MMU-9013404", "R-HSA-9927418", "R-BTA-2173789", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-HSA-446343", "R-RNO-202733", "R-CEL-202733", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-3000178", "R-HSA-2173789", "R-CEL-216083", "R-BTA-198933", "R-CEL-9860927", "R-RNO-198933", "R-CEL-1236973", "R-MMU-166016", "R-CEL-114608", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-RNO-1566948", "R-DME-354192", "R-BTA-166016", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-75892", "R-MMU-198933", "R-DME-445144", "R-HSA-198933", "R-MMU-8875513", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-372708", "R-RNO-4420097", "R-MMU-114608", "R-HSA-9725554", "R-HSA-3000157", "R-CEL-1566977", "R-BTA-3000178", "R-HSA-1566948", "R-RNO-354194", "R-RNO-2129379", "R-CEL-9013149", "R-RNO-114608", "R-BTA-202733", "R-MMU-372708", "R-HSA-210990", "R-RNO-8875513", "R-DME-1236973", "R-HSA-416700", "R-HSA-6802946", "R-DME-2129379", "R-HSA-9938206", "R-MMU-446343", "R-HSA-354192", "R-CEL-210991", "R-HSA-216083", "R-HSA-445355", "R-RNO-210991", "R-CEL-445144", "R-HSA-1566977", "R-HSA-9927432", "R-HSA-354194", "R-HSA-9679191", "R-HSA-9830674", "R-DME-3000170", "R-CEL-4420097", "R-MMU-2129379"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-445355:r:Smooth Muscle Contraction", "R-CEL-1566948:r:Elastic fibre formation", "R-DME-445355:r:Smooth Muscle Contraction", "R-MMU-3000170:r:Syndecan interactions", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-9634597:r:GPER1 signaling", "R-RNO-210990:r:PECAM1 interactions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-1566977:r:Fibronectin matrix formation", "R-RNO-445144:r:Signal transduction by L1", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-447041:r:CHL1 interactions", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000157:r:Laminin interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-1566948:r:Elastic fibre formation", "R-DME-354192:r:Integrin signaling", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-CEL-1566977:r:Fibronectin matrix formation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-1566948:r:Elastic fibre formation", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-354192:r:Integrin signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-210991:r:Basigin interactions", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR033761": {"description": "Negative modulator of initiation of replication SeqA, N-terminal", "go_ids": [], "go_terms": [], "name": "SeqA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033762": {"description": "MCM OB domain", "go_ids": [], "go_terms": [], "name": "MCM_OB", "pathway_ids": ["R-XTR-69052", "R-RNO-68949", "R-HSA-9825895", "R-GGA-68689", "R-RNO-68962", "R-SPO-68867", "R-HSA-68949", "R-HSA-176974", "R-CEL-68962", "R-XTR-68689", "R-HSA-113507", "R-BTA-68949", "R-MMU-68949", "R-RNO-176187", "R-DME-69052", "R-CEL-68867", "R-BTA-68962", "R-SCE-69052", "R-BTA-176187", "R-DME-68962", "R-DDI-68962", "R-HSA-69052", "R-GGA-68949", "R-HSA-68962", "R-CEL-69052", 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"R-CEL-68962:r:Activation of the pre-replicative complex", "R-XTR-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-DME-69052:r:Switching of origins to a post-replicative state", "R-CEL-68867:r:Assembly of the pre-replicative complex", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-SCE-69052:r:Switching of origins to a post-replicative state", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-GGA-68949:r:Orc1 removal from chromatin", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-CEL-69052:r:Switching of origins 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and repair proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-8943724:r:Regulation of PTEN gene transcription"], "type": "Domain"}, "IPR033764": {"description": "SD-repeat containing protein, B domain", "go_ids": [], "go_terms": [], "name": "Sdr_B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033767": {"description": "Tail tubular protein Gp11", "go_ids": [], "go_terms": [], "name": "Tail_Gp11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033768": {"description": "Hydin adenylate kinase-like domain", "go_ids": [], "go_terms": [], "name": "Hydin_ADK", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033769": {"description": "Transcription termination factor FttA, KH domain", "go_ids": [], "go_terms": [], "name": "TffA_KH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033770": {"description": "Exosome complex exonuclease RRP44, S1 domain", "go_ids": [], "go_terms": [], "name": "RRP44_S1", "pathway_ids": ["R-MMU-9930044", "R-MMU-450385", "R-MMU-6791226", "R-HSA-9930044", "R-CEL-450385", "R-SCE-450513", "R-MMU-429958", "R-SPO-9930044", "R-CEL-450513", "R-SCE-450385", "R-HSA-450385", "R-SCE-429958", "R-HSA-380994", "R-MMU-450513", "R-CEL-429958", "R-MMU-450604", "R-HSA-6791226", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-HSA-429958", "R-SPO-429958"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Domain"}, "IPR033771": {"description": "Rrp44-like cold shock domain", "go_ids": [], "go_terms": [], "name": "Rrp44_CSD1", "pathway_ids": ["R-MMU-9930044", "R-MMU-450385", "R-MMU-6791226", "R-HSA-9930044", "R-CEL-450385", "R-SCE-450513", "R-MMU-429958", "R-SPO-9930044", "R-CEL-450513", "R-SCE-450385", "R-HSA-9820865", "R-HSA-450385", "R-SCE-429958", "R-HSA-380994", "R-MMU-450513", "R-CEL-429958", "R-MMU-450604", "R-HSA-6791226", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-HSA-429958", "R-SPO-429958"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Domain"}, "IPR033772": {"description": "UPA domain", "go_ids": [], "go_terms": [], "name": "UPA", "pathway_ids": ["R-CEL-373752", "R-HSA-418889", "R-HSA-418886", "R-RNO-373752", "R-HSA-373752", "R-MMU-373752", "R-DME-373752"], "pathways": ["R-CEL-373752:r:Netrin-1 signaling", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-RNO-373752:r:Netrin-1 signaling", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-373752:r:Netrin-1 signaling", "R-DME-373752:r:Netrin-1 signaling"], "type": "Domain"}, "IPR033773": {"description": "CBX family C-terminal motif", "go_ids": [], "go_terms": [], "name": "CBX7_C", "pathway_ids": ["R-HSA-4655427", "R-DME-8939243", "R-HSA-3108214", "R-HSA-2559580", "R-MMU-3899300", "R-MMU-4570464", "R-MMU-8939243", "R-DME-3108214", "R-MMU-8943724", "R-DME-2559580", "R-MMU-4551638", "R-HSA-8939243", "R-DME-4570464", "R-HSA-8943724", "R-DME-3899300", "R-HSA-4570464", "R-MMU-3108214", "R-HSA-3899300", "R-HSA-4551638", "R-DME-8943724"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-8943724:r:Regulation of PTEN gene transcription"], "type": "Conserved_site"}, "IPR033774": {"description": "Yaf2/RYBP C-terminal binding motif", "go_ids": [], "go_terms": [], "name": "YAF2_RYBP", "pathway_ids": ["R-MMU-8953750", "R-DRE-8953750", "R-HSA-8939243", "R-DRE-8939243", "R-HSA-8953750", "R-MMU-8939243"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Conserved_site"}, "IPR033775": {"description": "Protein of unknown function (DUF5137)", "go_ids": [], "go_terms": [], "name": "DUF5137", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033776": {"description": "COMMD1 N-terminal domain", "go_ids": [], "go_terms": [], "name": "COMMD1_N", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation"], "type": "Domain"}, "IPR033777": {"description": "Viral cysteine endopeptidase C107", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "Peptidase_C107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033778": {"description": "Cuticle protein CPCFC", "go_ids": ["GO:0042302"], "go_terms": ["GO:0042302:structural constituent of cuticle:F"], "name": "CPCFC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033779": {"description": "Domain of unknown function DUF5300", "go_ids": [], "go_terms": [], "name": "DUF5300", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033782": {"description": "Domain of unknown function DUF5301", "go_ids": [], "go_terms": [], "name": "DUF5301", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033787": {"description": "ssDNA-binding protein ThermoDBP", "go_ids": ["GO:0003697"], "go_terms": ["GO:0003697:single-stranded DNA binding:F"], "name": "ThermoDBP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033789": {"description": "Gal11, coactivator domain", "go_ids": [], "go_terms": [], "name": "Gal11_coact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033791": {"description": "Pesticin, translocation and receptor binding domain", "go_ids": [], "go_terms": [], "name": "Pesticin_N_RB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033793": {"description": "Cytochrome oxidase Caa3-type, subunit IV", "go_ids": [], "go_terms": [], "name": "Caa3-IV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033795": {"description": "Uncharacterised protein Clospo_01618-like domain", "go_ids": [], "go_terms": [], "name": "Clospo_01618-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033799": {"description": "CdiA toxin, EC869-like", "go_ids": ["GO:0004530"], "go_terms": ["GO:0004530:deoxyribonuclease I activity:F"], "name": "CdiA_EC869-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033801": {"description": "CBM6/CBM35/CBM36-like 1", "go_ids": [], "go_terms": [], "name": "CBM6-CBM35-CBM36-like_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033803": {"description": "Golvesin/Xly, CBD-like", "go_ids": [], "go_terms": [], "name": "CBD-like_Golvesin-Xly", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033805": {"description": "Immunity protein CdiI-2-like", "go_ids": [], "go_terms": [], "name": "CdiI-2-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033808": {"description": "Burkholderia lethal factor 1", "go_ids": ["GO:0051097"], "go_terms": ["GO:0051097:negative regulation of helicase activity:P"], "name": "BPSL1549", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033856": {"description": "Flavin-dependent tryptophan halogenase", "go_ids": [], "go_terms": [], "name": "Trp_halogen", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033865": {"description": "Machado-Joseph disease protein", "go_ids": ["GO:0004843", "GO:0016579"], "go_terms": ["GO:0004843:cysteine-type deubiquitinase activity:F", "GO:0016579:protein deubiquitination:P"], "name": "Ataxin-3", "pathway_ids": ["R-HSA-9615017", "R-MMU-5689877", "R-RNO-5689877", "R-CEL-9615017", "R-MMU-9615017", "R-RNO-9615017", "R-GGA-9615017", "R-HSA-5689877", "R-CEL-5689877", "R-GGA-5689877"], "pathways": ["R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-5689877:r:Josephin domain DUBs", "R-RNO-5689877:r:Josephin domain DUBs", "R-CEL-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-RNO-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-GGA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-5689877:r:Josephin domain DUBs", "R-CEL-5689877:r:Josephin domain DUBs", "R-GGA-5689877:r:Josephin domain DUBs"], "type": "Family"}, "IPR033867": {"description": "Ribosome assembly factor Mrt4", "go_ids": ["GO:0000027"], "go_terms": ["GO:0000027:ribosomal large subunit assembly:P"], "name": "Mrt4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033871": {"description": "Sm-like protein LSm5", "go_ids": [], "go_terms": [], "name": "LSm5", "pathway_ids": ["R-SPO-430039", "R-BTA-430039", "R-HSA-72163", "R-MMU-430039", "R-MMU-72163", "R-SCE-430039", "R-HSA-430039", "R-DDI-430039", "R-BTA-72163"], "pathways": ["R-SPO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-BTA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DDI-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR033872": {"description": "Non-specific lipid-transfer protein type 2", "go_ids": ["GO:0006869"], "go_terms": ["GO:0006869:lipid transport:P"], "name": "nsLTP2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033877": {"description": "Nitroreductase Frm2/Hbn1-like", "go_ids": ["GO:0034599"], "go_terms": ["GO:0034599:cellular response to oxidative stress:P"], "name": "Frm2/Hbn1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033880": {"description": "SPFH domain, YdjI-like", "go_ids": [], "go_terms": [], "name": "SPFH_YdjI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033885": {"description": "Alkane/xylene monooxygenase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "AlkB/XylM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033891": {"description": "Tetratricopeptide repeat protein 38", "go_ids": [], "go_terms": [], "name": "TTC38", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR033892": {"description": "Ferredoxin--NADP reductase, bacteria", "go_ids": ["GO:0004324"], "go_terms": ["GO:0004324:ferredoxin-NADP+ reductase activity:F"], "name": "FNR_bac", "pathway_ids": ["PWY-101", "PWY-8271"], "pathways": ["PWY-101:t:photosynthesis light reactions", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)"], "type": "Family"}, "IPR033894": {"description": "Heat shock protein beta-3", "go_ids": [], "go_terms": [], "name": "HSPB3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR033895": {"description": "UDP-GlcNAc-dolichyl-phosphate GlcNAc phosphotransferase", "go_ids": ["GO:0003975", "GO:0006488"], "go_terms": ["GO:0003975:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity:F", "GO:0006488:dolichol-linked oligosaccharide biosynthetic process:P"], "name": "GPT", "pathway_ids": ["R-SCE-446193", "R-MMU-446193", "R-SPO-446193", "R-HSA-446193", "R-DDI-446193", "R-HSA-4549356"], "pathways": ["R-SCE-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-MMU-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-DDI-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-4549356:r:Defective DPAGT1 causes CDG-1j, CMSTA2"], "type": "Family"}, "IPR033900": {"description": "Porin domain, Gram-negative type", "go_ids": ["GO:0015288", "GO:0016020"], "go_terms": ["GO:0015288:porin activity:F", "GO:0016020:membrane:C"], "name": "Gram_neg_porin_domain", "pathway_ids": ["R-HSA-5603041", "R-HSA-1236974", "R-HSA-5602498", "R-HSA-3000484", "R-HSA-166058", "R-HSA-168179"], "pathways": ["R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade"], "type": "Domain"}, "IPR033931": {"description": "PDK1-type, PH domain", "go_ids": [], "go_terms": [], "name": "PDK1-typ_PH", "pathway_ids": ["R-DDI-5218921", "R-SPO-2730905", "R-DDI-114604", "R-MMU-5607764", "R-MMU-114604", "R-DME-114604", "R-SPO-389357", "R-MMU-5625740", "R-SPO-202424", "R-DME-9634635", "R-DME-5218921", "R-RNO-5218920", "R-DDI-202424", "R-DDI-6804757", "R-MMU-389357", "R-HSA-5218920", "R-RNO-5625740", "R-MMU-392451", "R-HSA-6804757", "R-RNO-202424", "R-DDI-5218920", "R-SPO-9634635", "R-HSA-114604", "R-SPO-392451", "R-RNO-389357", "R-DDI-9634635", "R-SPO-165158", "R-RNO-165158", "R-HSA-5674400", "R-SPO-5218920", "R-DME-354192", "R-HSA-5218921", "R-DDI-392451", "R-DME-5218920", "R-RNO-6804757", "R-MMU-9634635", "R-DME-110478", "R-DME-165158", "R-DDI-9856530", "R-MMU-2871837", "R-DME-1257604", "R-RNO-2730905", "R-DME-110523", "R-HSA-389357", "R-MMU-2730905", "R-HSA-1257604", "R-MMU-354192", "R-DME-389357", "R-HSA-165158", "R-DME-202424", "R-MMU-9856530", "R-DME-392451", "R-HSA-9735871", "R-RNO-1257604", "R-HSA-9634635", "R-HSA-5625740", "R-SPO-5218921", "R-DME-5625740", "R-SPO-5625740", "R-HSA-2871837", "R-RNO-354192", "R-SPO-114604", "R-MMU-165158", "R-HSA-2730905", "R-SPO-6804757", "R-SPO-1257604", "R-HSA-5607764", "R-MMU-5218921", "R-SPO-9856530", "R-MMU-202424", "R-HSA-354192", "R-DDI-2730905", "R-DDI-1257604", "R-MMU-5218920", "R-RNO-9634635", "R-MMU-6804757", "R-RNO-392451", "R-MMU-1257604", "R-DME-2730905", "R-DDI-165158", "R-HSA-9755779", "R-RNO-9856530", "R-RNO-114604", "R-RNO-5218921", "R-RNO-5607764", "R-DDI-389357", "R-HSA-444257", "R-HSA-9856530", "R-HSA-202424", "R-DME-9856530", "R-HSA-392451", "R-RNO-2871837"], "pathways": ["R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-DME-114604:r:GPVI-mediated activation cascade", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-SPO-202424:r:Downstream TCR signaling", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-202424:r:Downstream TCR signaling", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-RNO-202424:r:Downstream TCR signaling", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-SPO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-SPO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-SPO-165158:r:Activation of AKT2", "R-RNO-165158:r:Activation of AKT2", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-354192:r:Integrin signaling", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-DME-110478:r:Insulin signaling pathway", "R-DME-165158:r:Activation of AKT2", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-110523:r:TOR signaling pathway", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-354192:r:Integrin signaling", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-165158:r:Activation of AKT2", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-SPO-5218921:r:VEGFR2 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protectins", "R-SPO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-9018676:r:Biosynthesis of D-series resolvins", "R-DDI-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-DDI-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SPO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9018681:r:Biosynthesis of protectins", "R-DDI-9018676:r:Biosynthesis of D-series resolvins", "R-SCE-9018681:r:Biosynthesis of protectins", "R-BTA-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins"], "type": "Family"}, "IPR034016": {"description": "Aminopeptidase N-type", "go_ids": [], "go_terms": [], "name": "M1_APN-typ", "pathway_ids": ["R-SSC-2022377", "R-HSA-6798695", "R-RNO-983170", "R-RNO-1236977", "R-CEL-983170", "R-SCE-6798695", "R-SCE-983170", "R-RNO-2022377", "R-MMU-1236977", "R-HSA-983168", "R-HSA-2022377", "R-CEL-983168", "R-HSA-1236977", "R-BTA-983170", "R-HSA-983170", "R-HSA-1445148", "R-MMU-983170", "R-MMU-983168", "R-SPO-983168", "R-MMU-6798695", "R-SCE-983168", "R-CFA-6798695", "R-RNO-983168", "R-RNO-6798695", "R-MMU-2022377"], "pathways": ["R-SSC-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-1236977:r:Endosomal/Vacuolar pathway", "R-CEL-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Family"}, "IPR034026": {"description": "ESAT-6 secretion machinery protein EssA", "go_ids": [], "go_terms": [], "name": "EssA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034078": {"description": "Transcription factor NFX1 family", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "NFX1_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034085": {"description": "TOG domain", "go_ids": [], "go_terms": [], "name": "TOG", "pathway_ids": ["R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-380284", "R-XTR-380270", "R-MMU-68877", "R-DRE-2467813", "R-DRE-141444", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-DDI-8951664", "R-HSA-2565942", "R-XTR-141444", "R-HSA-380320", "R-XTR-5620912", "R-HSA-68877", "R-HSA-192905", "R-DRE-5663220", "R-MMU-5620912", "R-MMU-9648025", "R-HSA-5620912", "R-DDI-6798695", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-MMU-141444", "R-MMU-380259", "R-HSA-2500257", "R-DDI-917937", "R-DRE-2500257", "R-MMU-380270", "R-XTR-5663220", "R-XTR-380284", "R-HSA-141444", "R-HSA-9648025", "R-XTR-68877", "R-HSA-380270", "R-RNO-5663220", "R-XTR-380259", "R-XTR-380320", "R-XTR-2565942", "R-MMU-8854518", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-428890", "R-HSA-380259", "R-XTR-8854518", "R-XTR-2500257", "R-MMU-5663220", "R-RNO-141444", "R-HSA-9633012"], "pathways": ["R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DDI-8951664:r:Neddylation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-192905:r:vRNP Assembly", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-917937:r:Iron uptake and transport", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR034136": {"description": "Topoisomerase 6 subunit A/Spo11, TOPRIM domain", "go_ids": [], "go_terms": [], "name": "TOPRIM_Topo6A/Spo11", "pathway_ids": ["R-HSA-912446"], "pathways": ["R-HSA-912446:r:Meiotic recombination"], "type": "Domain"}, "IPR034139": {"description": "OLD protein-like, TOPRIM domain", "go_ids": [], "go_terms": [], "name": "TOPRIM_OLD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR034178": {"description": "Isobutyryl-CoA dehydrogenase", "go_ids": ["GO:0006629", "GO:0003995"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0003995:acyl-CoA dehydrogenase activity:F"], "name": "IBD", "pathway_ids": ["PWY-8182", "PWY-5109", "PWY-8181", "R-DDI-70895", "R-DDI-9837999", "R-BTA-70895", "R-HSA-9837999", "R-MMU-9837999", "R-HSA-70895", "R-MMU-70895", "R-BTA-9837999"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-BTA-9837999:r:Mitochondrial protein degradation"], "type": "Family"}, "IPR034180": {"description": "Medium-chain specific acyl-CoA dehydrogenase", "go_ids": ["GO:0005739", "GO:0070991", "GO:0006635"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0070991:medium-chain fatty acyl-CoA dehydrogenase activity:F", "GO:0006635:fatty acid beta-oxidation:P"], "name": "MCAD", "pathway_ids": ["PWY-7094", "PWY-8354", "PWY-8181", "R-DME-77348", "R-HSA-1989781", "R-MMU-77346", "R-RNO-77346", "R-HSA-77288", "R-RNO-77288", "R-BTA-77346", "R-RNO-77348", "R-DME-77288", "R-HSA-77348", "R-MMU-77348", "R-MMU-77288", "R-BTA-77288", "R-DME-77346", "R-HSA-77346", "R-BTA-77348"], "pathways": ["PWY-7094:t:fatty acid salvage", "PWY-8354:t:adipate degradation", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "R-DME-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-RNO-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-DME-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-BTA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "type": "Family"}, "IPR034183": {"description": "Isovaleryl-CoA dehydrogenase", "go_ids": ["GO:0003995"], "go_terms": ["GO:0003995:acyl-CoA dehydrogenase activity:F"], "name": "IVD", "pathway_ids": ["R-MMU-70895", "R-HSA-9914355", "R-HSA-70895", "R-RNO-70895"], "pathways": ["R-MMU-70895:r:Branched-chain amino acid catabolism", "R-HSA-9914355:r:Isovaleric acidemia", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Family"}, "IPR034189": {"description": "MARF1, RNA recognition motif 1", "go_ids": [], "go_terms": [], "name": "MARF1_RRM1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR034257": {"description": "Acinus, RNA recognition motif", "go_ids": [], "go_terms": [], "name": "Acinus_RRM", "pathway_ids": ["R-MMU-111465", "R-HSA-72163", "R-MMU-72163", "R-HSA-111465"], "pathways": ["R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Domain"}, "IPR034291": {"description": "Thiamine phosphate synthase", "go_ids": ["GO:0009228", "GO:0004789"], "go_terms": ["GO:0009228:thiamine biosynthetic process:P", "GO:0004789:thiamine-phosphate diphosphorylase activity:F"], "name": "TMP_synthase", "pathway_ids": ["PWY-8457", "PWY-6894", "PWY-6908", "PWY-6907", "PWY-7356", "PWY-6897", "PWY-6893"], "pathways": ["PWY-8457:t:thiamine diphosphate salvage V", "PWY-6894:t:thiamine diphosphate biosynthesis I (E. coli)", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "PWY-6897:t:thiamine diphosphate salvage II", "PWY-6893:t:thiamine diphosphate biosynthesis II (Bacillus)"], "type": "Family"}, "IPR034294": {"description": "Aquaporin transporter", "go_ids": [], "go_terms": [], "name": "Aquaporin_transptr", "pathway_ids": ["R-CFA-432047", "R-HSA-1247673", "R-RNO-1237044", "R-RNO-1247673", "R-HSA-9925561", "R-DME-432047", "R-DME-1237044", "R-HSA-1237044", "R-BTA-1247673", "R-DDI-1237044", "R-RNO-432047", "R-HSA-432040", "R-CFA-432040", "R-DDI-432047", "R-CFA-1237044", "R-DME-432040", "R-HSA-9925563", "R-HSA-3299685", "R-MMU-1237044", "R-DDI-1247673", "R-DME-1247673", "R-MMU-1247673", "R-SSC-432047", "R-DDI-432040", "R-BTA-432047", "R-GGA-432047", "R-MMU-432040", "R-MMU-432047", "R-BTA-432040", "R-HSA-432047", "R-RNO-432040", "R-BTA-1237044", "R-CFA-1247673"], "pathways": ["R-CFA-432047:r:Passive transport by Aquaporins", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-DME-432047:r:Passive transport by Aquaporins", "R-DME-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-BTA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-DDI-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-432047:r:Passive transport by Aquaporins", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DDI-432047:r:Passive transport by Aquaporins", "R-CFA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DME-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DDI-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-DME-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-SSC-432047:r:Passive transport by Aquaporins", "R-DDI-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-432047:r:Passive transport by Aquaporins", "R-GGA-432047:r:Passive transport by Aquaporins", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-432047:r:Passive transport by Aquaporins", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-432047:r:Passive transport by Aquaporins", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-CFA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide"], "type": "Family"}, "IPR034300": {"description": "NADP transhydrogenase beta-like domain", "go_ids": [], "go_terms": [], "name": "PNTB-like", "pathway_ids": ["R-MMU-71403", "R-HSA-71403", "R-BTA-71403"], "pathways": ["R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Domain"}, "IPR034334": {"description": "Prostaglandin E synthase 2", "go_ids": ["GO:0050220"], "go_terms": ["GO:0050220:prostaglandin-E synthase activity:F"], "name": "PGES2", "pathway_ids": ["PWY-8399", "PWY-8396", "PWY-8397", "R-MMU-6798695", "R-HSA-6798695", "R-HSA-2162123", "R-DRE-2162123", "R-DRE-6798695", "R-MMU-2162123"], "pathways": ["PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-8397:t:arachidonate metabolites biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-DRE-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "type": "Family"}, "IPR034338": {"description": "Glutathione S-transferases, subfamily 4, C-terminal", "go_ids": [], "go_terms": [], "name": "GST_4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR034372": {"description": "Serine/threonine-protein kinase Kist", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "UHMK1", "pathway_ids": ["R-HSA-9634638", "R-MMU-9634638", "R-RNO-9634638"], "pathways": ["R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling"], "type": "Family"}, "IPR034382": {"description": "3,6-anhydro-alpha-L-galactonate cycloisomerase", "go_ids": ["GO:0019388", "GO:0016853"], "go_terms": ["GO:0019388:galactose catabolic process:P", "GO:0016853:isomerase activity:F"], "name": "AHGA_cycloisomerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034386": {"description": "2-Deoxy-scyllo-inosamine dehydrogenase (BtrN-like)", "go_ids": ["GO:0017000", "GO:0016491"], "go_terms": ["GO:0017000:antibiotic biosynthetic process:P", "GO:0016491:oxidoreductase activity:F"], "name": "BtrN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034391": {"description": "AdoMet-like SPASM domain containing protein", "go_ids": [], "go_terms": [], "name": "AdoMet-like_SPASM_containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034393": {"description": "TatSF1-like", "go_ids": [], "go_terms": [], "name": "TatSF1-like", "pathway_ids": ["R-SPO-9770562", "R-HSA-72163", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163"], "pathways": ["R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR034405": {"description": "F420, menaquinone cofactor biosynthesis", "go_ids": [], "go_terms": [], "name": "F420", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034422": {"description": "HydE/PylB-like", "go_ids": [], "go_terms": [], "name": "HydE/PylB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034428": {"description": "ThiH/NocL/HydG-like", "go_ids": [], "go_terms": [], "name": "ThiH/NoCL/HydG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034430": {"description": "Protein PSY", "go_ids": [], "go_terms": [], "name": "PSY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034432": {"description": "Nucleoporin nup60", "go_ids": ["GO:0044615", "GO:0006913", "GO:0017056"], "go_terms": ["GO:0044615:nuclear pore nuclear basket:C", "GO:0006913:nucleocytoplasmic transport:P", "GO:0017056:structural constituent of nuclear pore:F"], "name": "Nup60", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034433": {"description": "Vomeromodulin", "go_ids": ["GO:0007608"], "go_terms": ["GO:0007608:sensory perception of smell:P"], "name": "Vomeromodulin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034436": {"description": "3-Methyl-2-indolic acid methyltransferase, NocN/NosN-like", "go_ids": [], "go_terms": [], "name": "NocN/NosN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034438": {"description": "4-Hydroxyphenylacetate decarboxylase activase", "go_ids": ["GO:0051539", "GO:0016491"], "go_terms": ["GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "4-hPhe_decarboxylase_activase", "pathway_ids": ["PWY-6530"], "pathways": ["PWY-6530:t:perchlorate reduction"], "type": "Family"}, "IPR034439": {"description": "Diuretic hormone class 2-like", "go_ids": ["GO:0008613", "GO:0007589"], "go_terms": ["GO:0008613:diuretic hormone activity:F", "GO:0007589:body fluid secretion:P"], "name": "DH2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034441": {"description": "Bursicon subunit beta", "go_ids": ["GO:0001664", "GO:0005184", "GO:0031395"], "go_terms": ["GO:0001664:G protein-coupled receptor binding:F", "GO:0005184:neuropeptide hormone activity:F", "GO:0031395:bursicon neuropeptide hormone complex:C"], "name": "Bursicon_suB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034443": {"description": "Meiotically up-regulated protein PB1A10.08", "go_ids": [], "go_terms": [], "name": "PB1A10.08", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034444": {"description": "NADH-ubiquinone oxidoreductase 17.8kDa subunit", "go_ids": ["GO:0005739"], "go_terms": ["GO:0005739:mitochondrion:C"], "name": "Nuo17.8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034446": {"description": "Fibronectin type III domain-containing protein 10", "go_ids": [], "go_terms": [], "name": "Fndc10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034450": {"description": "Adipogenesis regulatory factor", "go_ids": ["GO:0045600", "GO:0005634"], "go_terms": ["GO:0045600:positive regulation of fat cell differentiation:P", "GO:0005634:nucleus:C"], "name": "ADIRF", "pathway_ids": ["R-HSA-381340"], "pathways": ["R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR034452": {"description": "Transmembrane protein PVRIG", "go_ids": ["GO:0038023", "GO:0050860"], "go_terms": ["GO:0038023:signaling receptor activity:F", "GO:0050860:negative regulation of T cell receptor signaling pathway:P"], "name": "TM_PVRIG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034455": {"description": "Biogenesis of lysosome-related organelles complex 1, subunit CNL1", "go_ids": ["GO:0031083"], "go_terms": ["GO:0031083:BLOC-1 complex:C"], "name": "CNL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034456": {"description": "Mediator of RNA polymerase II transcription subunit 28", "go_ids": ["GO:0016592", "GO:0006355"], "go_terms": ["GO:0016592:mediator complex:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "MED28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034457": {"description": "Organic radical-activating enzymes", "go_ids": [], "go_terms": [], "name": "Organic_radical-activating", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034461": {"description": "Adropin", "go_ids": [], "go_terms": [], "name": "Adropin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034462": {"description": "Benzylsuccinate synthase activase", "go_ids": ["GO:0042203"], "go_terms": ["GO:0042203:toluene catabolic process:P"], "name": "Benzylsuc_synthase_activase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034465": {"description": "Pyruvate formate-lyase activase", "go_ids": [], "go_terms": [], "name": "Pyruvate_for-lyase_activase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034466": {"description": "Methyltransferase, class B", "go_ids": [], "go_terms": [], "name": "Methyltransferase_Class_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034471": {"description": "GDGT/MA synthase", "go_ids": ["GO:0008168", "GO:0051539"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "GDGT/MA_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034474": {"description": "Methyltransferase, class D", "go_ids": [], "go_terms": [], "name": "Methyltransferase_Class_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034479": {"description": "Fe-coproporphyrin III synthase-like", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "AhbC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034480": {"description": "Heme synthase-like", "go_ids": [], "go_terms": [], "name": "Heme_synthase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034485": {"description": "Anaerobic Cys-type sulfatase-maturating enzyme", "go_ids": [], "go_terms": [], "name": "Anaerobic_Cys-type_sulfatase-m", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034491": {"description": "Anaerobic Ser-type sulfatase-maturating enzyme", "go_ids": [], "go_terms": [], "name": "Anaerob_Ser_sulfatase-maturase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034493": {"description": "Antilisterial bacteriocin subtilosin biosynthesis protein (AlbA)", "go_ids": [], "go_terms": [], "name": "AlbA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034497": {"description": "Bacteriochlorophyll C12 methyltransferase", "go_ids": [], "go_terms": [], "name": "Bacteriochlorophyll_C12_MT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034498": {"description": "Bacteriochlorophyll C8 methyltransferase", "go_ids": [], "go_terms": [], "name": "Bacteriochlorophyll_C8_MT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034505": {"description": "Anaerobic coproporphyrinogen-III oxidase", "go_ids": [], "go_terms": [], "name": "Coproporphyrinogen-III_oxidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034508": {"description": "Spectinomycin biosynthesis", "go_ids": [], "go_terms": [], "name": "Spectinomycin_biosynthesis", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034514": {"description": "Carbapenem intermediate methyltransferase ThnK-like", "go_ids": [], "go_terms": [], "name": "ThnK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034515": {"description": "Carbapenem intermediate methyltransferase, ThnL-like", "go_ids": [], "go_terms": [], "name": "ThnL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034519": {"description": "UDP-N-acetyl-tunicamine-uracil synthase TunB-like", "go_ids": [], "go_terms": [], "name": "TunB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034529": {"description": "Cytidylyl-2-hydroxyethylphosphonate methyltransferase fom3-like", "go_ids": ["GO:0008168", "GO:0017000", "GO:0051539"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0017000:antibiotic biosynthetic process:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "Fom3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034530": {"description": "Hopanoid C2-methyltransferase, HpnP-like", "go_ids": [], "go_terms": [], "name": "HpnP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034531": {"description": "Methylation of yatakemycin, YtkT", "go_ids": [], "go_terms": [], "name": "Methylation_of_yatakemycin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034532": {"description": "OxsB-like", "go_ids": [], "go_terms": [], "name": "OxsB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034533": {"description": "Paromamine deoxygenase", "go_ids": [], "go_terms": [], "name": "Paromamine_deoxygenase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034534": {"description": "Bleomycin-like antibiotic biosynthesis, pyrimidine ring methyltransferase", "go_ids": [], "go_terms": [], "name": "Pyrimidine_methyltransferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034543": {"description": "Long chronological lifespan protein 2", "go_ids": [], "go_terms": [], "name": "LCL2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034545": {"description": "Meiosis-specific kinetochore protein", "go_ids": ["GO:0000776", "GO:0051754"], "go_terms": ["GO:0000776:kinetochore:C", "GO:0051754:meiotic sister chromatid cohesion, centromeric:P"], "name": "Meikin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034546": {"description": "Protein PAIR1", "go_ids": ["GO:0048236", "GO:0070192"], "go_terms": ["GO:0048236:plant-type sporogenesis:P", "GO:0070192:chromosome organization involved in meiotic cell cycle:P"], "name": "PAIR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034547": {"description": "Tte1186a maturase", "go_ids": [], "go_terms": [], "name": "Tte1186a_maturase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034549": {"description": "Sperm acrosome membrane-associated protein 6", "go_ids": ["GO:0007342"], "go_terms": ["GO:0007342:fusion of sperm to egg plasma membrane involved in single fertilization:P"], "name": "SPACA6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034551": {"description": "Mucin-20", "go_ids": ["GO:0048012"], "go_terms": ["GO:0048012:hepatocyte growth factor receptor signaling pathway:P"], "name": "MUC20", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-MMU-8851805", "R-MMU-913709", "R-HSA-977068", "R-HSA-5083625", "R-MMU-977068", "R-HSA-5621480", "R-HSA-8851805", "R-HSA-913709"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-MMU-8851805:r:MET activates RAS signaling", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Family"}, "IPR034553": {"description": "Mitochondrial import receptor subunit TOM5 homologue, plants", "go_ids": ["GO:0005742"], "go_terms": ["GO:0005742:mitochondrial outer membrane translocase complex:C"], "name": "TOM5_plants", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034554": {"description": "Mitochondrial import receptor subunit TOM6 homologue, plants", "go_ids": ["GO:0005742"], "go_terms": ["GO:0005742:mitochondrial outer membrane translocase complex:C"], "name": "TOM6_plants", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034556": {"description": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase", "go_ids": ["GO:0008033", "GO:0051539"], "go_terms": ["GO:0008033:tRNA processing:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "tRNA_wybutosine-synthase", "pathway_ids": ["PWY-7286", "PWY-7285", "R-HSA-6782861"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)"], "type": "Family"}, "IPR034557": {"description": "Threonylcarbamoyladenosine tRNA methylthiotransferase", "go_ids": ["GO:0035598", "GO:0035600"], "go_terms": ["GO:0035598:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity:F", "GO:0035600:tRNA methylthiolation:P"], "name": "ThrcA_tRNA_MEthiotransferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034559": {"description": "Spore photoproduct lyase, Clostridia type", "go_ids": ["GO:0003913", "GO:1904047"], "go_terms": ["GO:0003913:DNA photolyase activity:F", "GO:1904047:S-adenosyl-L-methionine binding:F"], "name": "SPL_Clostridia", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034560": {"description": "Spore photoproduct lyase, Bacilli type", "go_ids": ["GO:1904047", "GO:0051539", "GO:0042601", "GO:0003913"], "go_terms": ["GO:1904047:S-adenosyl-L-methionine binding:F", "GO:0051539:4 iron, 4 sulfur cluster binding:F", "GO:0042601:endospore-forming forespore:C", "GO:0003913:DNA photolyase activity:F"], "name": "SPL_Bacilli", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034561": {"description": "Negative regulator of systemic acquired resistance SNI1", "go_ids": ["GO:0031348", "GO:0006974", "GO:0045892", "GO:0005634", "GO:0030915"], "go_terms": ["GO:0031348:negative regulation of defense response:P", "GO:0006974:DNA damage response:P", "GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0005634:nucleus:C", "GO:0030915:Smc5-Smc6 complex:C"], "name": "SNI1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034563": {"description": "Protein PALE CRESS", "go_ids": ["GO:0009536", "GO:0010239", "GO:0009658", "GO:0048366"], "go_terms": ["GO:0009536:plastid:C", "GO:0010239:chloroplast mRNA processing:P", "GO:0009658:chloroplast organization:P", "GO:0048366:leaf development:P"], "name": "PALE_CRESS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034565": {"description": "Putative cell wall protein", "go_ids": [], "go_terms": [], "name": "Put_cell_wall", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034566": {"description": "Type 2 DNA topoisomerase 6 subunit B-like, plants", "go_ids": ["GO:0042138"], "go_terms": ["GO:0042138:meiotic DNA double-strand break formation:P"], "name": "MTOPVIB_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034568": {"description": "Mediator of RNA polymerase II transcription subunit 30", "go_ids": ["GO:0016592"], "go_terms": ["GO:0016592:mediator complex:C"], "name": "MED30", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034569": {"description": "Photosynthetic NDH subunit of subcomplex B 5, chloroplastic", "go_ids": ["GO:0009507", "GO:0006979"], "go_terms": ["GO:0009507:chloroplast:C", "GO:0006979:response to oxidative stress:P"], "name": "PNSB5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034570": {"description": "Photosynthetic NDH subunit of subcomplex B 4, chloroplastic", "go_ids": ["GO:0009535", "GO:0010598", "GO:0009773"], "go_terms": ["GO:0009535:chloroplast thylakoid membrane:C", "GO:0010598:NAD(P)H dehydrogenase complex (plastoquinone):C", "GO:0009773:photosynthetic electron transport in photosystem I:P"], "name": "PNSB4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034571": {"description": "Protein APEM9", "go_ids": ["GO:0015919"], "go_terms": ["GO:0015919:peroxisomal membrane transport:P"], "name": "APEM9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034572": {"description": "Protein MULTIPLE CHLOROPLAST DIVISION SITE 1", "go_ids": ["GO:0010020", "GO:0009507"], "go_terms": ["GO:0010020:chloroplast fission:P", "GO:0009507:chloroplast:C"], "name": "MCD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034573": {"description": "Succinate dehydrogenase subunit 7, mitochondrial", "go_ids": ["GO:0045273"], "go_terms": ["GO:0045273:respiratory chain complex II (succinate dehydrogenase):C"], "name": "SDH7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034574": {"description": "Succinate dehydrogenase subunit 6, mitochondrial", "go_ids": ["GO:0045273"], "go_terms": ["GO:0045273:respiratory chain complex II (succinate dehydrogenase):C"], "name": "SDH6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034575": {"description": "Outer envelope pore protein 21", "go_ids": ["GO:0008308", "GO:0044070"], "go_terms": ["GO:0008308:voltage-gated monoatomic anion channel activity:F", "GO:0044070:regulation of monoatomic anion transport:P"], "name": "OEP21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034577": {"description": "Protein NIM1-INTERACTING 2", "go_ids": ["GO:0010112"], "go_terms": ["GO:0010112:regulation of systemic acquired resistance:P"], "name": "NIMIN-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034581": {"description": "Protein PLASTID TRANSCRIPTIONALLY ACTIVE 12", "go_ids": ["GO:0009507", "GO:0005634", "GO:0009416", "GO:0090228", "GO:0006355"], "go_terms": ["GO:0009507:chloroplast:C", "GO:0005634:nucleus:C", "GO:0009416:response to light stimulus:P", "GO:0090228:positive regulation of red or far-red light signaling pathway:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "PTAC12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034583": {"description": "Protein EMBRYONIC FLOWER 1", "go_ids": ["GO:0009910", "GO:0045892", "GO:0048367"], "go_terms": ["GO:0009910:negative regulation of flower development:P", "GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0048367:shoot system development:P"], "name": "EMF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034584": {"description": "Sperm microtubule inner protein 8", "go_ids": [], "go_terms": [], "name": "SPMIP8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034585": {"description": "Retinitis pigmentosa 9 protein", "go_ids": ["GO:0008380"], "go_terms": ["GO:0008380:RNA splicing:P"], "name": "PAP-1", 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{"description": "POLYCHOME/GIGAS CELL1", "go_ids": ["GO:1904667", "GO:0005634", "GO:0051783"], "go_terms": ["GO:1904667:negative regulation of ubiquitin protein ligase activity:P", "GO:0005634:nucleus:C", "GO:0051783:regulation of nuclear division:P"], "name": "POLYCHOME/GIG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034592": {"description": "Coiled-coil domain-containing protein 91", "go_ids": ["GO:0048193"], "go_terms": ["GO:0048193:Golgi vesicle transport:P"], "name": "CCDC91", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034593": {"description": "D-galactonate dehydratase DgoD-like", "go_ids": [], "go_terms": [], "name": "DgoD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034595": {"description": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8", "go_ids": ["GO:0032981", "GO:0005739"], "go_terms": ["GO:0032981:mitochondrial respiratory chain complex I assembly:P", "GO:0005739:mitochondrion:C"], "name": 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WASPs and WAVEs"], "type": "Homologous_superfamily"}, "IPR034683": {"description": "Cytidylyltransferase IspD/TarI", "go_ids": ["GO:0070567"], "go_terms": ["GO:0070567:cytidylyltransferase activity:F"], "name": "IspD/TarI", "pathway_ids": ["PWY-7560", "R-XTR-9939291", "R-HSA-9939291", "R-RNO-9939291", "R-DRE-9939291", "R-MMU-9939291"], "pathways": ["PWY-7560:t:methylerythritol phosphate pathway II", "R-XTR-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-RNO-9939291:r:Matriglycan biosynthesis on DAG1", "R-DRE-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1"], "type": "Family"}, "IPR034686": {"description": "Terpene cyclase-like 2", "go_ids": ["GO:0010333"], "go_terms": ["GO:0010333:terpene synthase activity:F"], "name": "Terpene_cyclase-like_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034687": {"description": "Elongator complex protein 3-like", "go_ids": [], "go_terms": [], "name": "ELP3-like", "pathway_ids": ["PWY-6829", "PWY-7888", "R-HSA-3214847"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR034688": {"description": "Lysis inhibition accessory protein rIII", "go_ids": ["GO:0140678"], "go_terms": ["GO:0140678:molecular function inhibitor activity:F"], "name": "Linr3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034696": {"description": "Antiholin T4 type", "go_ids": ["GO:0140678"], "go_terms": ["GO:0140678:molecular function inhibitor activity:F"], "name": "RI_T4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034701": {"description": "Diadenylate cyclase CdaA", "go_ids": ["GO:0006171", "GO:0004016"], "go_terms": ["GO:0006171:cAMP biosynthetic process:P", "GO:0004016:adenylate cyclase activity:F"], "name": "CdaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034704": {"description": "Large ribosomal subunit protein bL28/bL31-like superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL28/bL31-like_sf", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-DME-9937383"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Homologous_superfamily"}, "IPR034719": {"description": "Inhibitor of hydrogen peroxide resistance", "go_ids": [], "go_terms": [], "name": "IprA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034720": {"description": "Viral alkaline exonuclease", "go_ids": [], "go_terms": [], "name": "Viral_alk_exo", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR034728": {"description": "Peptidase A3B domain", "go_ids": [], "go_terms": [], "name": "Peptidase_A3B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR034733": {"description": "Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta", "go_ids": [], "go_terms": [], "name": "AcCoA_carboxyl_beta", "pathway_ids": ["PWY-5743", "PWY-5789", "PWY-6722", "PWY-4381", "PWY-5744", "R-HSA-163765", "R-CEL-196780", "R-MMU-9837999", "R-DME-196780", "R-DDI-75105", "R-MMU-200425", "R-SPO-75105", "R-DDI-70895", "R-HSA-196780", "R-RNO-75105", "R-HSA-70895", "R-RNO-9837999", "R-DDI-200425", "R-HSA-3371599", "R-MMU-75105", "R-MMU-196780", "R-DME-70895", "R-RNO-70895", "R-SPO-196780", "R-RNO-196780", "R-DDI-196780", "R-HSA-200425", "R-MMU-70895", "R-SPO-200425", "R-RNO-200425", "R-CEL-70895", "R-HSA-71032", "R-HSA-75105", "R-HSA-9909438", "R-RNO-71032", "R-HSA-9837999", "R-SCE-196780", "R-MMU-71032", "R-SCE-200425", "R-HSA-2426168", "R-SCE-75105"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-6722:t:candicidin biosynthesis", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "PWY-5744:t:glyoxylate assimilation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-CEL-196780:r:Biotin transport and metabolism", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DME-196780:r:Biotin transport and metabolism", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-200425:r:Carnitine shuttle", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-196780:r:Biotin transport and metabolism", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DDI-200425:r:Carnitine shuttle", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-196780:r:Biotin transport and metabolism", "R-DME-70895:r:Branched-chain amino acid catabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-DDI-196780:r:Biotin transport and metabolism", "R-HSA-200425:r:Carnitine shuttle", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-SPO-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9909438:r:3-Methylcrotonyl-CoA carboxylase deficiency", "R-RNO-71032:r:Propionyl-CoA catabolism", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SCE-196780:r:Biotin transport and metabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-SCE-200425:r:Carnitine shuttle", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR034734": {"description": "Zinc finger C2HC RNF-type", "go_ids": [], "go_terms": [], "name": "ZF_C2HC_RNF", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-HSA-936440", "R-HSA-983168", "R-RNO-983168", "R-SSC-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR034741": {"description": "Terpene cyclase-like 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Terpene_cyclase-like_1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR034743": {"description": "RH1 domain", "go_ids": [], "go_terms": [], "name": "RH1", "pathway_ids": ["R-MMU-525793", "R-HSA-2132295", "R-DME-525793", "R-HSA-525793", "R-MMU-2132295", "R-CEL-525793"], "pathways": ["R-MMU-525793:r:Myogenesis", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-525793:r:Myogenesis", "R-HSA-525793:r:Myogenesis", "R-MMU-2132295:r:MHC class II antigen presentation", "R-CEL-525793:r:Myogenesis"], "type": "Domain"}, "IPR034754": {"description": "Gemini of Cajal bodies-associated protein 8", "go_ids": ["GO:0032797", "GO:0000387"], "go_terms": ["GO:0032797:SMN complex:C", "GO:0000387:spliceosomal snRNP assembly:P"], "name": "GEMIN8", "pathway_ids": ["R-BTA-191859", "R-HSA-191859", "R-CEL-191859", "R-MMU-191859", "R-HSA-9754678"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly", "R-CEL-191859:r:snRNP Assembly", "R-MMU-191859:r:snRNP Assembly", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery"], "type": "Family"}, "IPR034756": {"description": "Type II secretion system (T2SS), protein M subtype b", "go_ids": [], "go_terms": [], "name": "T2SSM_b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034762": {"description": "Bacterial/eukaryotic lysine-tRNA ligase, class II", "go_ids": ["GO:0006430", "GO:0004824", "GO:0005524"], "go_terms": ["GO:0006430:lysyl-tRNA aminoacylation:P", "GO:0004824:lysine-tRNA ligase activity:F", "GO:0005524:ATP binding:F"], "name": "Lys-tRNA-ligase_II_bac/euk", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-HSA-2408522", "R-RNO-9856649", "R-SCE-9856649", "R-SPO-9856649", "R-HSA-9856649", "R-CEL-9856649", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SPO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Family"}, "IPR034763": {"description": "Venom allergen 3, insect", "go_ids": [], "go_terms": [], "name": "P14a_insect", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034764": {"description": "Nucleoside transporter ENT1/ENT2", "go_ids": ["GO:1901642", "GO:0005337", "GO:0016020"], "go_terms": ["GO:1901642:nucleoside transmembrane transport:P", "GO:0005337:nucleoside transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "ENT1/ENT2", "pathway_ids": ["R-MMU-9748787", "R-MMU-9755088", "R-SCE-9748787", "R-RNO-83936", "R-HSA-9748787", "R-SCE-9755088", "R-HSA-83936", "R-RNO-9755088", "R-MMU-83936", "R-SCE-83936", "R-HSA-9755088", "R-RNO-9748787"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-MMU-9755088:r:Ribavirin ADME", "R-SCE-9748787:r:Azathioprine ADME", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-9748787:r:Azathioprine ADME", "R-SCE-9755088:r:Ribavirin ADME", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-9755088:r:Ribavirin ADME", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-SCE-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-9755088:r:Ribavirin ADME", "R-RNO-9748787:r:Azathioprine ADME"], "type": "Family"}, "IPR034768": {"description": "WhiB-like iron-sulfur binding domain", "go_ids": [], "go_terms": [], "name": "4FE4S_WBL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR034772": {"description": "CPSF6/7", "go_ids": [], "go_terms": [], "name": "CPSF6/7", "pathway_ids": ["R-HSA-9013422", "R-HSA-9770562", "R-RNO-9013422", "R-DRE-77595", "R-MMU-9770562", "R-DME-77595", "R-MMU-77595", "R-HSA-73856", "R-RNO-77595", "R-MMU-73856", "R-HSA-72187", "R-DME-9013422", "R-RNO-73856", "R-HSA-77595", "R-DME-9770562", "R-MMU-9013422", "R-DRE-73856", "R-MMU-72187", "R-DRE-9770562", "R-RNO-9770562", "R-DME-73856", "R-DRE-9013422", "R-HSA-5655302", "R-HSA-9918481", "R-HSA-1839117"], "pathways": ["R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-DRE-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Family"}, "IPR034783": {"description": "Sorting nexin-4", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "SNX4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034804": {"description": "Fumarate reductase/succinate dehydrogenase, transmembrane subunit", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "SQR/QFR_C/D", "pathway_ids": ["R-HSA-9854311", "R-BTA-9854311", "R-BTA-71403", "R-DRE-9854311", "R-SSC-9854311", "R-DRE-71403", "R-HSA-611105", "R-RNO-9854311", "R-SSC-71403", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-MMU-71403", "R-SCE-71403", "R-XTR-9854311", "R-DME-71403", "R-DDI-71403", "R-RNO-71403", "R-XTR-71403", "R-HSA-71403", "R-GGA-71403"], "pathways": ["R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-GGA-71403:r:Citric acid cycle (TCA cycle)"], "type": "Homologous_superfamily"}, "IPR034819": {"description": "Cytoplasmic polyadenylation element-binding protein", "go_ids": ["GO:0003730", "GO:0045182", "GO:0006417"], "go_terms": ["GO:0003730:mRNA 3'-UTR binding:F", "GO:0045182:translation regulator activity:F", "GO:0006417:regulation of translation:P"], "name": "CPEB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034829": {"description": "DnaD-like domain superfamily", "go_ids": [], "go_terms": [], "name": "DnaD-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR034870": {"description": "TAF15/EWS/TLS family", "go_ids": ["GO:0003723", "GO:0006355"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "TET_fam", "pathway_ids": ["R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-DME-674695", "R-MMU-9770562", "R-MMU-72163", "R-DME-76042", "R-DME-72163", "R-DME-73779", "R-DME-6804756", "R-HSA-167162", "R-HSA-167161", "R-DME-9770562", "R-HSA-72163", "R-DME-73776", "R-HSA-73776", "R-HSA-6804756", "R-DME-72203", "R-HSA-75953", "R-DME-75953", "R-HSA-76042", "R-HSA-674695", "R-HSA-167172", "R-HSA-9918481", "R-HSA-73779"], "pathways": ["R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR034871": {"description": "Allene oxide cyclase superfamily", "go_ids": ["GO:0046423", "GO:0009695"], "go_terms": ["GO:0046423:allene-oxide cyclase activity:F", "GO:0009695:jasmonic acid biosynthetic process:P"], "name": "Allene_oxi_cyc_sf", "pathway_ids": ["PWY-735"], "pathways": ["PWY-735:t:jasmonic acid biosynthesis"], "type": "Homologous_superfamily"}, "IPR034882": {"description": "CENP-B, dimerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "Dimerisation_CENP-B_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR034884": {"description": "Mitochondrial cytochrome c oxidase subunit VIc/VIIs", "go_ids": [], "go_terms": [], "name": "Cytochrome_c_oxidase_VIc/VIIs", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-MMU-9707564", "R-HSA-9707564", "R-MMU-5628897", "R-RNO-5628897", "R-MMU-611105", "R-RNO-9707564", "R-MMU-9864848", "R-BTA-9864848", "R-HSA-5628897", "R-BTA-5628897", "R-BTA-611105", "R-BTA-9707564"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR034904": {"description": "Fe-S cluster assembly domain superfamily", "go_ids": [], "go_terms": [], "name": "FSCA_dom_sf", "pathway_ids": ["R-SCE-9857492", "R-HSA-2564830", "R-DME-9857492", "R-MMU-9857492", "R-HSA-9857492"], "pathways": ["R-SCE-9857492:r:Protein lipoylation", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-DME-9857492:r:Protein lipoylation", "R-MMU-9857492:r:Protein lipoylation", "R-HSA-9857492:r:Protein lipoylation"], "type": "Homologous_superfamily"}, "IPR034907": {"description": "Nucleoside diphosphate kinase-like domain", "go_ids": [], "go_terms": [], "name": "NDK-like_dom", "pathway_ids": ["R-BTA-499943", "R-SPO-9755088", "R-MMU-6798695", "R-SPO-9748787", "R-SSC-9748787", "R-RNO-380270", "R-RNO-6798695", "R-RNO-499943", "PWY-7198", "PWY-7221", "PWY-7205", "PWY-6545", "PWY-7226", "PWY-7176", "PWY-7222", "PWY-7184", "PWY-7224", "PWY-7187", "PWY-8289", "PWY-7220", "PWY-7197", "PWY-7227", "PWY-7210", "R-CFA-499943", "R-HSA-6798695", "R-SPO-6798695", "R-SSC-6798695", "R-GGA-499943", "R-DDI-9748787", "R-SCE-9755088", "R-SCE-6798695", "R-BTA-6798695", "R-HSA-499943", "R-MMU-380320", "R-GGA-9755088", "R-MMU-499943", "R-RNO-380320", "R-MMU-9755088", "R-HSA-380320", "R-BTA-9755088", "R-HSA-9636383", "R-DME-499943", "R-DME-9748787", "R-DME-9755088", "R-SSC-9755088", "R-BTA-380320", "R-HSA-9755088", "R-CFA-9748787", "R-RNO-9748787", "R-DDI-499943", "R-MMU-9748787", "R-DDI-6798695", "R-SCE-9748787", "R-DDI-9755088", "R-SSC-499943", "R-DME-6798695", "R-RNO-9755088", "R-CFA-9755088", "R-MMU-380270", "R-SCE-499943", "R-HSA-380270", "R-SPO-499943", "R-GGA-6798695", "R-HSA-9748787", "R-BTA-380270", "R-BTA-9748787"], "pathways": ["R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-9755088:r:Ribavirin ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-9748787:r:Azathioprine ADME", "R-SSC-9748787:r:Azathioprine ADME", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-7221:t:guanosine ribonucleotides de novo biosynthesis", "PWY-7205:t:CMP phosphorylation", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7176:t:UTP and CTP de novo biosynthesis", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7224:t:purine deoxyribonucleosides salvage", "PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II", "PWY-8289:t:dZTP biosynthesis", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7197:t:pyrimidine deoxyribonucleotide phosphorylation", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-CFA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-GGA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-9748787:r:Azathioprine ADME", "R-SCE-9755088:r:Ribavirin ADME", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-9755088:r:Ribavirin ADME", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9755088:r:Ribavirin ADME", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-9755088:r:Ribavirin ADME", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-9748787:r:Azathioprine ADME", "R-DME-9755088:r:Ribavirin ADME", "R-SSC-9755088:r:Ribavirin ADME", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-9755088:r:Ribavirin ADME", "R-CFA-9748787:r:Azathioprine ADME", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-9748787:r:Azathioprine ADME", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-9748787:r:Azathioprine ADME", "R-DDI-9755088:r:Ribavirin ADME", "R-SSC-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-9755088:r:Ribavirin ADME", "R-CFA-9755088:r:Ribavirin ADME", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-9748787:r:Azathioprine ADME", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-9748787:r:Azathioprine ADME"], "type": "Domain"}, "IPR034913": {"description": "mS27/PTCD2", "go_ids": [], "go_terms": [], "name": "mS27/PTCD2", "pathway_ids": ["R-MMU-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Family"}, "IPR034941": {"description": "PydA-like", "go_ids": [], "go_terms": [], "name": "PydA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR034964": {"description": "Lumazine synthase", "go_ids": ["GO:0000906", "GO:0009231"], "go_terms": ["GO:0000906:6,7-dimethyl-8-ribityllumazine synthase activity:F", "GO:0009231:riboflavin biosynthetic process:P"], "name": "LS", "pathway_ids": ["PWY-6168", "PWY-6167"], "pathways": ["PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Family"}, "IPR034968": {"description": "Reelin", "go_ids": ["GO:0007417", "GO:0070325", "GO:0001764"], "go_terms": ["GO:0007417:central nervous system development:P", "GO:0070325:lipoprotein particle receptor binding:F", "GO:0001764:neuron migration:P"], "name": "Reelin", "pathway_ids": ["PWY-7884", "R-MMU-8866376", "R-HSA-8866376", "R-RNO-8866376"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-MMU-8866376:r:Reelin signalling pathway", "R-HSA-8866376:r:Reelin signalling pathway", "R-RNO-8866376:r:Reelin signalling pathway"], "type": "Family"}, "IPR034998": {"description": "Ankyrin repeat and LEM domain-containing protein 1", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "ANKLE1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035004": {"description": "Emerin", "go_ids": ["GO:0005635"], "go_terms": ["GO:0005635:nuclear envelope:C"], "name": "Emerin", "pathway_ids": ["R-HSA-9013405", "R-RNO-2995383", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-2995383", "R-MMU-9013404", "R-RNO-9609523", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-RNO-9013423", "R-HSA-4419969", "R-HSA-2980766", "R-MMU-2980766", "R-MMU-4419969", "R-RNO-9013404", "R-MMU-9609523", "R-HSA-9013408", "R-HSA-9609523", "R-RNO-9013408", "R-MMU-9013149", "R-RNO-4419969", "R-RNO-2980766", "R-MMU-2995383"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9013408:r:RHOG GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-2980766:r:Nuclear Envelope Breakdown", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation"], "type": "Family"}, "IPR035010": {"description": "Dual specificity protein phosphatase PHS1", "go_ids": ["GO:0009737", "GO:0043622", "GO:0004721"], "go_terms": ["GO:0009737:response to abscisic acid:P", "GO:0043622:cortical microtubule organization:P", "GO:0004721:phosphoprotein phosphatase activity:F"], "name": "PHS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035067": {"description": "V-type ATPase subunit C/D", "go_ids": [], "go_terms": [], "name": "V-type_ATPase_csu/dsu", "pathway_ids": ["R-MMU-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-DRE-9639288", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-XTR-77387", "R-RNO-1222556", "R-GGA-917977", "R-HSA-9639288", "R-DRE-983712", "R-RNO-983712", "R-XTR-1222556", "R-HSA-1222556", "R-XTR-917977", "R-SPO-917977", "R-DRE-1222556", "R-SPO-1222556", "R-DDI-1222556", "R-GGA-9639288", "R-XTR-983712", "R-RNO-917977", "R-SCE-917977", "R-SCE-1222556", "R-MMU-77387", "R-DDI-9639288", "R-BTA-1222556", "R-SCE-77387", "R-HSA-381038", "R-DRE-917977", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-GGA-77387", "R-RNO-77387", "R-BTA-917977", "R-HSA-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-XTR-9639288", "R-RNO-9639288", "R-GGA-1222556", "R-DRE-77387", "R-DDI-917977", "R-MMU-983712", "R-DDI-983712", "R-HSA-917977", "R-BTA-77387", 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recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-GGA-1222556:r:ROS and RNS production in phagocytes", "R-DRE-77387:r:Insulin receptor recycling", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-BTA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR035068": {"description": "Metalloprotease TldD/PmbA, N-terminal", "go_ids": [], "go_terms": [], "name": "TldD/PmbA_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035069": {"description": "Antitoxin HicB/UPF0150", "go_ids": [], "go_terms": [], "name": "HicB/UPF0150", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035070": {"description": "Streptogrisin prodomain", "go_ids": [], "go_terms": [], "name": "Streptogrisin_prodomain", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR035073": {"description": "At2g17340, three-helix bundle domain", "go_ids": [], "go_terms": [], "name": "At2g17340_3_helix_bundle", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664", "R-MMU-199220", "R-RNO-199220", "R-HSA-199220"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Homologous_superfamily"}, "IPR035074": {"description": "EspA/CesA-like", "go_ids": [], "go_terms": [], "name": "EspA/CesA-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035075": {"description": "PRMT5 arginine-N-methyltransferase", "go_ids": [], "go_terms": [], "name": "PRMT5", "pathway_ids": ["R-MMU-6804760", "R-MMU-191859", "R-HSA-191859", "R-DME-3214858", "R-CEL-3214858", "R-DDI-3214858", "R-SPO-3214858", "R-HSA-6804760", "R-HSA-3214858", "R-MMU-3214858"], "pathways": ["R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly", "R-DME-3214858:r:RMTs methylate histone arginines", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-3214858:r:RMTs methylate histone arginines"], "type": "Domain"}, "IPR035076": {"description": "Snake toxin/toxin-like", "go_ids": [], "go_terms": [], "name": "Toxin/TOLIP", "pathway_ids": ["R-MMU-975634", "R-MMU-163125", "R-HSA-8963889", "R-HSA-9918485", "R-MMU-8963889", "R-HSA-8963901", "R-BTA-163125", "R-HSA-975634", "R-MMU-8963901", "R-HSA-163125"], "pathways": ["R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8963901:r:Chylomicron remodeling", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-975634:r:Retinoid metabolism and transport", "R-MMU-8963901:r:Chylomicron remodeling", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Domain"}, "IPR035077": {"description": "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain", "go_ids": ["GO:0004611", "GO:0006094"], "go_terms": ["GO:0004611:phosphoenolpyruvate carboxykinase activity:F", "GO:0006094:gluconeogenesis:P"], "name": "PEP_carboxykinase_GTP_C", "pathway_ids": ["PWY-7383", "R-HSA-70263", "R-HSA-9615017", "R-HSA-381340", "R-HSA-9632974", "R-MMU-70263", "R-HSA-2161541", "R-GGA-352875", "R-DME-70263", "R-DDI-70263", "R-RNO-70263"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "R-HSA-70263:r:Gluconeogenesis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-HSA-2161541:r:Abacavir metabolism", "R-GGA-352875:r:Gluconeogenesis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR035078": {"description": "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal", "go_ids": ["GO:0004611", "GO:0006094"], "go_terms": ["GO:0004611:phosphoenolpyruvate carboxykinase activity:F", "GO:0006094:gluconeogenesis:P"], "name": "PEP_carboxykinase_GTP_N", "pathway_ids": ["PWY-7383", "R-HSA-70263", "R-HSA-9615017", "R-HSA-381340", "R-HSA-9632974", "R-MMU-70263", "R-HSA-2161541", "R-GGA-352875", "R-DME-70263", "R-DDI-70263", "R-RNO-70263"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "R-HSA-70263:r:Gluconeogenesis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-HSA-2161541:r:Abacavir metabolism", "R-GGA-352875:r:Gluconeogenesis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR035079": {"description": "Floricaula/Leafy protein, SAM domain", "go_ids": [], "go_terms": [], "name": "LFY_SAM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035080": {"description": "Lacto-N-biose phosphorylase-like, N-terminal TIM barrel domain", "go_ids": [], "go_terms": [], "name": "Lact_bio_phlase-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035081": {"description": "(5-formylfuran-3-yl)methyl phosphate synthase, archaea", "go_ids": ["GO:2001120", "GO:0016830"], "go_terms": ["GO:2001120:methanofuran biosynthetic process:P", "GO:0016830:carbon-carbon lyase activity:F"], "name": "4HFCP_synth_arc", "pathway_ids": ["PWY-5254"], "pathways": ["PWY-5254:t:methanofuran biosynthesis"], "type": "Family"}, "IPR035082": {"description": "Nrap protein domain 1", "go_ids": [], "go_terms": [], "name": "Nrap_D1", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR035083": {"description": "Nucleocapsid, N-terminal, Arenaviridae", "go_ids": [], "go_terms": [], "name": "Nucleocapsid_N_arenaviridae", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035084": {"description": "Nucleocapsid, C-terminal, Arenaviridae", "go_ids": [], "go_terms": [], "name": "Nucleocapsid_C_arenaviridae", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035085": {"description": "Urocanase, Rossmann-like domain", "go_ids": [], "go_terms": [], "name": "Urocanase_Rossmann-like", "pathway_ids": ["PWY-5030", "PWY-5028", "R-MMU-70921", "R-CEL-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5028:t:L-histidine degradation II", "R-MMU-70921:r:Histidine catabolism", "R-CEL-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Domain"}, "IPR035086": {"description": "D-glutamate N-acetyltransferase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DgcN-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035087": {"description": "MatP, N-terminal", "go_ids": [], "go_terms": [], "name": "MatP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035088": {"description": "Protective antigen, Ca-binding domain", "go_ids": [], "go_terms": [], "name": "PA_Ca-bd", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Domain"}, "IPR035089": {"description": "Tail sheath protein, subtilisin-like domain", "go_ids": [], "go_terms": [], "name": "Phage_sheath_subtilisin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035091": {"description": "Gap junction alpha-1 protein (Cx43), alpha-helix domain superfamily", "go_ids": [], "go_terms": [], "name": "Alpha_helix_dom_sf", "pathway_ids": ["R-RNO-190840", "R-HSA-9013409", "R-DRE-196025", "R-BTA-196025", "R-HSA-190840", "R-HSA-190861", "R-HSA-190873", "R-HSA-191650", "R-BTA-9013406", "R-HSA-9856532", "R-RNO-191650", "R-MMU-191650", "R-DRE-191650", "R-BTA-190873", "R-BTA-190861", "R-DRE-9013406", "R-BTA-191650", "R-MMU-190873", "R-RNO-196025", "R-RNO-190873", "R-RNO-9013406", "R-HSA-9705677", "R-HSA-190704", "R-HSA-190827", "R-HSA-196025", "R-BTA-190840", "R-MMU-190840", "R-RNO-190861", "R-MMU-196025", "R-DRE-190861", "R-MMU-9013406", "R-HSA-9013406", "R-DRE-190840", "R-MMU-190861"], "pathways": ["R-RNO-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-DRE-196025:r:Formation of annular gap junctions", "R-BTA-196025:r:Formation of annular gap junctions", "R-HSA-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-190861:r:Gap junction assembly", "R-HSA-190873:r:Gap junction degradation", "R-HSA-191650:r:Regulation of gap junction activity", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-RNO-191650:r:Regulation of gap junction activity", "R-MMU-191650:r:Regulation of gap junction activity", "R-DRE-191650:r:Regulation of gap junction activity", "R-BTA-190873:r:Gap junction degradation", "R-BTA-190861:r:Gap junction assembly", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-BTA-191650:r:Regulation of gap junction activity", "R-MMU-190873:r:Gap junction degradation", "R-RNO-196025:r:Formation of annular gap junctions", "R-RNO-190873:r:Gap junction degradation", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-HSA-190704:r:Oligomerization of connexins into connexons", "R-HSA-190827:r:Transport of connexins along the secretory pathway", "R-HSA-196025:r:Formation of annular gap junctions", "R-BTA-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-MMU-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-RNO-190861:r:Gap junction assembly", "R-MMU-196025:r:Formation of annular gap junctions", "R-DRE-190861:r:Gap junction assembly", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DRE-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-MMU-190861:r:Gap junction assembly"], "type": "Homologous_superfamily"}, "IPR035092": {"description": "EV matrix protein, C-terminal", "go_ids": [], "go_terms": [], "name": "EV_matrix_protein_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035093": {"description": "Toxin-antitoxin system, RelE/ParE toxin domain superfamily", "go_ids": [], "go_terms": [], "name": "RelE/ParE_toxin_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035094": {"description": "Histidine N-alpha-methyltransferase", "go_ids": [], "go_terms": [], "name": "EgtD", "pathway_ids": ["PWY-7550", "PWY-7255"], "pathways": ["PWY-7550:t:ergothioneine biosynthesis II (fungi)", "PWY-7255:t:ergothioneine biosynthesis I (bacteria)"], "type": "Family"}, "IPR035097": {"description": "Peptidase M29, N-terminal", "go_ids": [], "go_terms": [], "name": "M29_N-terminal", "pathway_ids": ["PWY-7694", "PWY-6423", "PWY-7954"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-6423:t:hemoglobin degradation", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis"], "type": "Homologous_superfamily"}, "IPR035098": {"description": "YNR034W-A/EGO2 superfamily", "go_ids": [], "go_terms": [], "name": "YNR034W-A/EGO2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035099": {"description": "Anthrax toxin, edema factor, C-terminal", "go_ids": [], "go_terms": [], "name": "Anthrax_toxin_C-terminal", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Homologous_superfamily"}, "IPR035100": {"description": "Transcription elongation factor, IIS-type", "go_ids": [], "go_terms": [], "name": "TF_IIS-typ", "pathway_ids": ["R-RNO-6781823", "R-DDI-6782135", "R-HSA-6781827", "R-MMU-6782135", "R-HSA-167238", "R-DME-6781823", "R-RNO-674695", "R-DME-6796648", "R-DDI-6782210", "R-DME-75955", "R-HSA-6796648", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-MMU-6781823", "R-BTA-6781823", "R-HSA-167152", "R-DDI-6796648", "R-HSA-6782210", "R-SPO-6796648", "R-SCE-6782210", "R-DME-6782135", "R-BTA-6796648", "R-SCE-6796648", "R-RNO-6782210", "R-BTA-75955", "R-CEL-75955", "R-MMU-6796648", "R-DME-674695", "R-HSA-167243", "R-RNO-6796648", "R-BTA-6782135", "R-RNO-6782135", "R-RNO-75955", "R-DDI-6781823", "R-HSA-6782135", "R-BTA-674695", "R-CEL-6782210", "R-MMU-674695", "R-CEL-6781823", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-HSA-167290", "R-HSA-75955", "R-CEL-112382", "R-SPO-6782210", "R-CEL-6782135", "R-RNO-112382", "R-BTA-6782210", "R-MMU-6782210", "R-DME-6782210", "R-HSA-674695", "R-SPO-6782135", "R-CEL-6796648", "R-HSA-112382", "R-SCE-6782135"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-6782135:r:Dual incision in TC-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782135:r:Dual incision in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-6782135:r:Dual incision in TC-NER", "R-RNO-6782135:r:Dual incision in TC-NER", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Family"}, "IPR035102": {"description": "Phosphomevalonate kinase", "go_ids": [], "go_terms": [], "name": "Phosphomevalonate_kinase", "pathway_ids": ["PWY-7391", "PWY-922"], "pathways": ["PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)"], "type": "Family"}, "IPR035106": {"description": "Spastin, chordate", "go_ids": ["GO:0008568"], "go_terms": ["GO:0008568:microtubule severing ATPase activity:F"], "name": "Spastin_chordate", "pathway_ids": ["R-XTR-9668328", "R-GGA-9668328", "R-DRE-9668328", "R-BTA-9668328", "R-HSA-9668328", "R-SSC-9668328", "R-MMU-9668328", "R-RNO-9668328"], "pathways": ["R-XTR-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-GGA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DRE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-BTA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SSC-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III"], "type": "Family"}, "IPR035107": {"description": "tRNA thiolation protein, TtcA/Ctu1 type", "go_ids": ["GO:0008033"], "go_terms": ["GO:0008033:tRNA processing:P"], "name": "tRNA_thiolation_TtcA_Ctu1", "pathway_ids": ["PWY-7889", "PWY-7888", "PWY-6892", "PWY-5303", "PWY-7904", "PWY-7250", "PWY-7892", "PWY-8164", "PWY-6675", "PWY-8179", "PWY-7891", "PWY-7887", "R-HSA-6782315"], "pathways": ["PWY-7889:t:tRNA-uridine 2-thiolation (mammalian mitochondria)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6892:t:thiazole component of thiamine diphosphate biosynthesis I", "PWY-5303:t:thiosulfate oxidation II (via tetrathionate)", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-8164:t:bis(guanylyl molybdopterin) cofactor sulfurylation", "PWY-6675:t:sulfur oxidation IV (intracellular sulfur)", "PWY-8179:t:platensimycin biosynthesis", "PWY-7891:t:tRNA-uridine 2-thiolation (yeast mitochondria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR035109": {"description": "Ancylostoma-associated secreted protein related", "go_ids": [], "go_terms": [], "name": "ASPR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035110": {"description": "HCMV protein UL42", "go_ids": [], "go_terms": [], "name": "UL42", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035111": {"description": "Protein of unknown function DUF5516", "go_ids": [], "go_terms": [], "name": "DUF5516", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035112": {"description": "Viral unique long protein 21a", "go_ids": [], "go_terms": [], "name": "UL21a", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR035113": {"description": "Protein 14, SARS-like", "go_ids": [], "go_terms": [], "name": "Protein_14_SARS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035114": {"description": "Gene product 67", "go_ids": [], "go_terms": [], "name": "GP67", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035115": {"description": "Protein of unknown function DUF5514", "go_ids": [], "go_terms": [], "name": "DUF5514", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035116": {"description": "Protein of unknown function DUF5510", "go_ids": [], "go_terms": [], "name": "DUF5510", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035117": {"description": "Inclusion membrane protein D", "go_ids": [], "go_terms": [], "name": "IncD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035118": {"description": "Inclusion membrane protein E", "go_ids": [], "go_terms": [], "name": "IncE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035119": {"description": "Inclusion membrane protein F", "go_ids": [], "go_terms": [], "name": "IncF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035120": {"description": "Protein of unknown function DUF5509", "go_ids": [], "go_terms": [], "name": "DUF5509", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035121": {"description": "Uncharacterized protein US30-like", "go_ids": [], "go_terms": [], "name": "US30-like", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR035122": {"description": "Uncharacterized protein B277", "go_ids": [], "go_terms": [], "name": "B277", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035123": {"description": "Viral unique long protein 16", "go_ids": [], "go_terms": [], "name": "UL16", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR035124": {"description": "YpjCB-like", "go_ids": [], "go_terms": [], "name": "DUF5508", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035125": {"description": "Protein ORF45", "go_ids": [], "go_terms": [], "name": "ORF45", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035126": {"description": "Secreted clade V protein", "go_ids": [], "go_terms": [], "name": "SCVP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035127": {"description": "Strongylid L4 protein-like", "go_ids": [], "go_terms": [], "name": "SL4P", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035128": {"description": "Viral unique short region 10", "go_ids": [], "go_terms": [], "name": "US10", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Family"}, "IPR035129": {"description": "Viral unique short region 6", "go_ids": [], "go_terms": [], "name": "US6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035131": {"description": "Protein of unknown function DUF5502", "go_ids": [], "go_terms": [], "name": "DUF5502", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035132": {"description": "Protein of unknown function DUF5501", "go_ids": [], "go_terms": [], "name": "DUF5501", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035133": {"description": "Protein of unknown function DUF5499", "go_ids": [], "go_terms": [], "name": "DUF5499", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035134": {"description": "Protein of unknown function DUF5498", "go_ids": [], "go_terms": [], "name": "DUF5498", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035135": {"description": "Protein of unknown function DUF5496", "go_ids": [], "go_terms": [], "name": "DUF5496", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035136": {"description": "Protein of unknown function DUF5486", "go_ids": [], "go_terms": [], "name": "DUF5486", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035137": {"description": "Discriminator of mRNA degradation", "go_ids": [], "go_terms": [], "name": "Dmd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035138": {"description": "Protein of unknown function DUF5485", "go_ids": [], "go_terms": [], "name": "DUF5485", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035139": {"description": "Bacillus competence protein S", "go_ids": [], "go_terms": [], "name": "ComS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035141": {"description": "Protein of unknown function DUF5484", "go_ids": [], "go_terms": [], "name": "DUF5484", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035142": {"description": "Cytomegalovirus UL20", "go_ids": [], "go_terms": [], "name": "UL20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035143": {"description": "Protein of unknown function DUF5483", "go_ids": [], "go_terms": [], "name": "DUF5483", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035145": {"description": "Protein of unknown function DUF5482", "go_ids": [], "go_terms": [], "name": "DUF5482", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035146": {"description": "Protein of unknown function DUF5481", "go_ids": [], "go_terms": [], "name": "DUF5481", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035147": {"description": "ECORI-T site protein ETM", "go_ids": [], "go_terms": [], "name": "ETM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035148": {"description": "Protein of unknown function DUF5480", "go_ids": [], "go_terms": [], "name": "DUF5480", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035149": {"description": "Protein of unknown function DUF5479", "go_ids": [], "go_terms": [], "name": "DUF5479", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035151": {"description": "Inhibitor of toxin/antitoxin system", "go_ids": [], "go_terms": [], "name": "TA_inhibitor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035152": {"description": "GA-like domain", "go_ids": [], "go_terms": [], "name": "GA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035153": {"description": "Protein of unknown function DUF5473", "go_ids": [], "go_terms": [], "name": "DUF5473", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035154": {"description": "Protein of unknown function DUF5472", "go_ids": [], "go_terms": [], "name": "DUF5472", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035155": {"description": "Protein of unknown function DUF5393", "go_ids": [], "go_terms": [], "name": "DUF5393", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035156": {"description": "Protein of unknown function DUF5471", "go_ids": [], "go_terms": [], "name": "DUF5471", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035157": {"description": "Protein of unknown function DUF5395", "go_ids": [], "go_terms": [], "name": "DUF5395", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035158": {"description": "Protein of unknown function DUF5396", "go_ids": [], "go_terms": [], "name": "DUF5396", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035160": {"description": "Protein of unknown function DUF5334", "go_ids": [], "go_terms": [], "name": "DUF5334", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035161": {"description": "Protein of unknown function DUF5332", "go_ids": [], "go_terms": [], "name": "DUF5332", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035162": {"description": "Protein of unknown function DUF5470", "go_ids": [], "go_terms": [], "name": "DUF5470", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035163": {"description": "Protochlamydia outer membrane protein", "go_ids": [], "go_terms": [], "name": "Pom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035164": {"description": "Cupiennin", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense response to bacterium:P"], "name": "Cupiennin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035165": {"description": "Protein of unknown function DUF5319", "go_ids": [], "go_terms": [], "name": "DUF5319", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035166": {"description": "34 kDa antigenic protein", "go_ids": [], "go_terms": [], "name": "MAP_0900", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035167": {"description": "Protein of unknown function DUF5316", "go_ids": [], "go_terms": [], "name": "DUF5316", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035168": {"description": "Protein of unknown function DUF5317", "go_ids": [], "go_terms": [], "name": "DUF5317", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035169": {"description": "Protein of unknown function DUF5318", "go_ids": [], "go_terms": [], "name": "DUF5318", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035170": {"description": "Metastasis-associated protein MTA1, R1 domain", "go_ids": [], "go_terms": [], "name": "MTA1_R1", "pathway_ids": ["R-MMU-73762", "R-RNO-8943724", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-RNO-73762", "R-MMU-8943724", "R-RNO-3214815", "R-HSA-6804758", "R-HSA-9844594", "R-RNO-3232118", "R-HSA-9845323", "R-HSA-8943724", "R-HSA-3232118", "R-MMU-3232118", "R-MMU-6804758", "R-HSA-9843940", "R-HSA-427389"], "pathways": ["R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-RNO-3214815:r:HDACs deacetylate histones", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-RNO-3232118:r:SUMOylation of transcription factors", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"], "type": "Domain"}, "IPR035171": {"description": "Aphid megourin", "go_ids": [], "go_terms": [], "name": "Megourin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035172": {"description": "Protein of unknown function DUF5302", "go_ids": [], "go_terms": [], "name": "DUF5302", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035173": {"description": "Sulfur globule protein CV1", "go_ids": [], "go_terms": [], "name": "SgpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035175": {"description": "Serine/threonine-protein kinase SMG1, N-terminal", "go_ids": [], "go_terms": [], "name": "SMG1_N", "pathway_ids": ["R-HSA-975957", "R-DRE-975957", "R-MMU-975957"], "pathways": ["R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Domain"}, "IPR035176": {"description": "Elicitor peptide", "go_ids": ["GO:0045087"], "go_terms": ["GO:0045087:innate immune response:P"], "name": "PEP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035177": {"description": "Type VI secretion system TssN", "go_ids": [], "go_terms": [], "name": "TssN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035178": {"description": "Protein of unknown function DUF5466", "go_ids": [], "go_terms": [], "name": "DUF5466", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035179": {"description": "Protein of unknown function DUF5314", "go_ids": [], "go_terms": [], "name": "DUF5314", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035180": {"description": "Protein of unknown function DUF5464", "go_ids": [], "go_terms": [], "name": "DUF5464", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035181": {"description": "Protein of unknown function DUF5463", "go_ids": [], "go_terms": [], "name": "DUF5463", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035182": {"description": "Protein of unknown function PsaF", "go_ids": [], "go_terms": [], "name": "PsaF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035183": {"description": "Protein of unknown function DUF5304", "go_ids": [], "go_terms": [], "name": "DUF5304", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035184": {"description": "DNA replication protein 17", "go_ids": ["GO:0039693"], "go_terms": ["GO:0039693:viral DNA genome replication:P"], "name": "Phage_Gp17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035185": {"description": "Protein of unknown function DUF5305", "go_ids": [], "go_terms": [], "name": "DUF5305", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035186": {"description": "Protein of unknown function DUF5308", "go_ids": [], "go_terms": [], "name": "DUF5308", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035187": {"description": "Mitochondrial peculiar membrane protein 1", "go_ids": [], "go_terms": [], "name": "Mpm1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035188": {"description": "Histone-like protein p6", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Histone-like_p6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035189": {"description": "Std1/Mth1", "go_ids": [], "go_terms": [], "name": "Std1/Mth1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035191": {"description": "K88 minor fimbrial subunit FaeF", "go_ids": [], "go_terms": [], "name": "FaeF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035192": {"description": "NUP160, helical domain, plants", "go_ids": [], "go_terms": [], "name": "NUP160_hel_plant", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035193": {"description": "Beta defensin 50", "go_ids": [], "go_terms": [], "name": "Defb50", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035194": {"description": "Protein of unknown function DUF5461", "go_ids": [], "go_terms": [], "name": "DUF5461", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035195": {"description": "ERMES regulator 1", "go_ids": ["GO:0007008"], "go_terms": ["GO:0007008:outer mitochondrial membrane organization:P"], "name": "Emr1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035196": {"description": "Protein of unknown function DUF5312", "go_ids": [], "go_terms": [], "name": "DUF5312", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035197": {"description": "Protein of unknown function DUF5313", "go_ids": [], "go_terms": [], "name": "DUF5313", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035198": {"description": "SU10 major capsid protein", "go_ids": [], "go_terms": [], "name": "SU10_MCP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035200": {"description": "Cell division control protein 24, OB domain 2", "go_ids": [], "go_terms": [], "name": "Cdc24_OB2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035201": {"description": "Cell division control protein 24, OB domain 1", "go_ids": [], "go_terms": [], "name": "Cdc24_OB1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035203": {"description": "Cell division control protein 24, OB domain 3", "go_ids": [], "go_terms": [], "name": "Cdc24_OB3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035204": {"description": "NADH-ubiquinone oxidoreductase 11kDa subunit", "go_ids": [], "go_terms": [], "name": "NDUFB11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035205": {"description": "Protein of unknown function DUF5320", "go_ids": [], "go_terms": [], "name": "DUF5320", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035207": {"description": "Domain of unknown function DUF5457", "go_ids": [], "go_terms": [], "name": "DUF5457", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035209": {"description": "Floricaula/leafy, DNA-binding C-terminal domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "FLO/LFY_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035210": {"description": "Protein of unknown function DUF5455", "go_ids": [], "go_terms": [], "name": "DUF5455", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035211": {"description": "Protein of unknown function DUF5325", "go_ids": [], "go_terms": [], "name": "DUF5325", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035212": {"description": "Matrix/matrix long, N-terminal", "go_ids": [], "go_terms": [], "name": "Mx/ML_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035213": {"description": "Protein of unknown function DUF5321", "go_ids": [], "go_terms": [], "name": "DUF5321", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035214": {"description": "Protein of unknown function DUF5324", "go_ids": [], "go_terms": [], "name": "DUF5324", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035215": {"description": "Protein of of unknown function DUF5454", "go_ids": [], "go_terms": [], "name": "DUF5454", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035217": {"description": "Protein of unknown function DUF5453", "go_ids": [], "go_terms": [], "name": "DUF5453", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035218": {"description": "Protein of unknown function DUF5327", "go_ids": [], "go_terms": [], "name": "DUF5327", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035219": {"description": "Protein of unknown function DUF5452", "go_ids": [], "go_terms": [], "name": "DUF5452", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035220": {"description": "Protein of unknown function DUF5330", "go_ids": [], "go_terms": [], "name": "DUF5330", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035221": {"description": "Protein of unknown function DUF5451", "go_ids": [], "go_terms": [], "name": "DUF5451", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035222": {"description": "Non-structural protein NS3", "go_ids": [], "go_terms": [], "name": "NS3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035223": {"description": "Protein of unknown function DUF5335", "go_ids": [], "go_terms": [], "name": "DUF5335", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035224": {"description": "TcfC, Usher-like barrel domain", "go_ids": [], "go_terms": [], "name": "Usher_TcfC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035225": {"description": "Protein of unknown function DUF5338", "go_ids": [], "go_terms": [], "name": "DUF5338", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035226": {"description": "Protein of unknown function DUF5450", "go_ids": [], "go_terms": [], "name": "DUF5450", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035227": {"description": "Protein HdcB", "go_ids": ["GO:0006548"], "go_terms": ["GO:0006548:L-histidine catabolic process:P"], "name": "HdcB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035228": {"description": "Protein of unknown function DUF5340", "go_ids": [], "go_terms": [], "name": "DUF5340", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035229": {"description": "Lysogeny maintenance PflM", "go_ids": [], "go_terms": [], "name": "PflM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035230": {"description": "Anti-sigma factor CnrY", "go_ids": [], "go_terms": [], "name": "CnrY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035231": {"description": "Protein of unknown function DUF5346", "go_ids": [], "go_terms": [], "name": "DUF5346", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035232": {"description": "Protein of unknown function DUF5347", "go_ids": [], "go_terms": [], "name": "DUF5347", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035233": {"description": "Protein of unknown function DUF5443", "go_ids": [], "go_terms": [], "name": "DUF5443", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035234": {"description": "IgGFc-binding protein, N-terminal", "go_ids": [], "go_terms": [], "name": "IgGFc-bd_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035235": {"description": "Protein of unknown function DUF5343", "go_ids": [], "go_terms": [], "name": "DUF5343", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035236": {"description": "RNA chaperone ProQ, C-terminal", "go_ids": [], "go_terms": [], "name": "ProQ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035237": {"description": "Protein of unknown function DUF5341", "go_ids": [], "go_terms": [], "name": "DUF5341", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035238": {"description": "Protein of unknown function DUF5345", "go_ids": [], "go_terms": [], "name": "DUF5345", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035239": {"description": "Cypovirus polyhedrin", "go_ids": [], "go_terms": [], "name": "CPV_Polyhedrin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035240": {"description": "SprT-like, zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "SprT_Zn_ribbon", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035241": {"description": "Domain of unknown function DUF5442", "go_ids": [], "go_terms": [], "name": "DUF5442", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035242": {"description": "Protein of unknown function DUF5329", "go_ids": [], "go_terms": [], "name": "DUF5329", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035243": {"description": "TamA, POTRA domain 1", "go_ids": [], "go_terms": [], "name": "TamA_POTRA_Dom_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035246": {"description": "Spermidine synthase, tetramerisation domain", "go_ids": [], "go_terms": [], "name": "Spermidine_synt_N", "pathway_ids": ["R-SPO-351202", "R-MMU-351202", "R-SCE-351202", "R-HSA-351202", "R-DDI-351202", "R-BTA-351202"], "pathways": ["R-SPO-351202:r:Metabolism of polyamines", "R-MMU-351202:r:Metabolism of polyamines", "R-SCE-351202:r:Metabolism of polyamines", "R-HSA-351202:r:Metabolism of polyamines", "R-DDI-351202:r:Metabolism of polyamines", "R-BTA-351202:r:Metabolism of polyamines"], "type": "Domain"}, "IPR035247": {"description": "PRMT5, TIM barrel domain", "go_ids": [], "go_terms": [], "name": "PRMT5_TIM", "pathway_ids": ["R-MMU-6804760", "R-MMU-191859", "R-HSA-191859", "R-DME-3214858", "R-CEL-3214858", "R-DDI-3214858", "R-SPO-3214858", "R-HSA-6804760", "R-HSA-3214858", "R-MMU-3214858"], "pathways": ["R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly", "R-DME-3214858:r:RMTs methylate histone arginines", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-3214858:r:RMTs methylate histone arginines"], "type": "Domain"}, "IPR035248": {"description": "PRMT5, oligomerisation domain", "go_ids": [], "go_terms": [], "name": "PRMT5_C", "pathway_ids": ["R-MMU-6804760", "R-MMU-191859", "R-HSA-191859", "R-DME-3214858", "R-CEL-3214858", "R-DDI-3214858", "R-SPO-3214858", "R-HSA-6804760", "R-HSA-3214858", "R-MMU-3214858"], "pathways": ["R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly", "R-DME-3214858:r:RMTs methylate histone arginines", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-3214858:r:RMTs methylate histone arginines"], "type": "Domain"}, "IPR035249": {"description": "Protein of unknown function DUF5441", "go_ids": [], "go_terms": [], "name": "DUF5441", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035250": {"description": "Metapneumovirus small hydrophobic protein", "go_ids": [], "go_terms": [], "name": "Metap_SH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035251": {"description": "ShlB, POTRA domain", "go_ids": [], "go_terms": [], "name": "ShlB_POTRA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035252": {"description": "Gene product 44", "go_ids": [], "go_terms": [], "name": "Gp44", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035253": {"description": "Putative lipoprotein, bacteria", "go_ids": [], "go_terms": [], "name": "Lipoprotein_22_bac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035255": {"description": "Domain of unknown function DUF5348", "go_ids": [], "go_terms": [], "name": "DUF5348", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035257": {"description": "Protein of unknown function DUF5349", "go_ids": [], "go_terms": [], "name": "DUF5349", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035258": {"description": "Protein of unknown function DUF5350", "go_ids": [], "go_terms": [], "name": "DUF5350", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035259": {"description": "Protein of unknown function DUF5437", "go_ids": [], "go_terms": [], "name": "DUF5437", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035260": {"description": "Filaments in between nuclei protein-1", "go_ids": [], "go_terms": [], "name": "Fin1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035262": {"description": "Protein of unknown function DUF5435", "go_ids": [], "go_terms": [], "name": "DUF5435", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035264": {"description": "Protein of unknown function DUF5434", "go_ids": [], "go_terms": [], "name": "DUF5434", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035265": {"description": "Colicin-K immunity", "go_ids": [], "go_terms": [], "name": "Colicin-K_immunity", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035269": {"description": "26S Proteasome non-ATPase regulatory subunit 9", "go_ids": ["GO:0070682"], "go_terms": ["GO:0070682:proteasome regulatory particle assembly:P"], "name": "PSMD9", "pathway_ids": ["R-SCE-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-CEL-9907900", "R-DME-9907900", "R-SPO-9907900", "R-BTA-9907900", "R-DDI-9907900"], "pathways": ["R-SCE-9907900:r:Proteasome assembly", "R-HSA-9907900:r:Proteasome assembly", "R-MMU-9907900:r:Proteasome assembly", "R-CEL-9907900:r:Proteasome assembly", "R-DME-9907900:r:Proteasome assembly", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-9907900:r:Proteasome assembly"], "type": "Family"}, "IPR035270": {"description": "Protein of unknown function DUF5433", "go_ids": [], "go_terms": [], "name": "DUF5433", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035271": {"description": "Protein of unknown function DUF5432", "go_ids": [], "go_terms": [], "name": "DUF5432", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035272": {"description": "Protein of unknown function DUF5351", "go_ids": [], "go_terms": [], "name": "DUF5351", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035273": {"description": "Protein of unknown function DUF5431", "go_ids": [], "go_terms": [], "name": "DUF5431", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035274": {"description": "Protein of unknown function DUF5352", "go_ids": [], "go_terms": [], "name": "DUF5352", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035275": {"description": "Small integral membrane protein 3", "go_ids": [], "go_terms": [], "name": "Smim3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035276": {"description": "Feline immunodeficiency virus OrfA protein", "go_ids": [], "go_terms": [], "name": "FIV_OrfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035277": {"description": "MalF, N-terminal", "go_ids": [], "go_terms": [], "name": "MalF_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035278": {"description": "Protein of unknown function DUF5355", "go_ids": [], "go_terms": [], "name": "DUF5355", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035279": {"description": "Protein of unknown function DUF5358", "go_ids": [], "go_terms": [], "name": "DUF5358", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035280": {"description": "Bacteriocin helveticin-J", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense response to bacterium:P"], "name": "Helveticin_J", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035281": {"description": "Protein of unknown function DUF5359", "go_ids": [], "go_terms": [], "name": "DUF5359", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035282": {"description": "Protein of unknown function DUF5429", "go_ids": [], "go_terms": [], "name": "DUF5429", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035283": {"description": "Protein Fmp23", "go_ids": [], "go_terms": [], "name": "Fmp23", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035284": {"description": "Protein of unknown function DUF5428", "go_ids": [], "go_terms": [], "name": "DUF5428", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035285": {"description": "Ctenitoxin", "go_ids": [], "go_terms": [], "name": "CNTX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035286": {"description": "Protein of unknown function DUF5361", "go_ids": [], "go_terms": [], "name": "DUF5361", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035287": {"description": "Protein of unknown function DUF5362", "go_ids": [], "go_terms": [], "name": "DUF5362", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035288": {"description": "Trans-membrane regulatory protein ToxS", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "ToxS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035289": {"description": "Protein of unknown function DUF5366", "go_ids": [], "go_terms": [], "name": "DUF5366", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035290": {"description": "Beta/Mu-diguetoxin-1", "go_ids": [], "go_terms": [], "name": "Beta/Mu-DGTX-Dc1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035291": {"description": "Protein of unknown function DUF5354", "go_ids": [], "go_terms": [], "name": "DUF5354", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035292": {"description": "Protein of unknown function DUF5363", "go_ids": [], "go_terms": [], "name": "DUF5363", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035293": {"description": "Vacuole-related protein 17", "go_ids": ["GO:0000011", "GO:0043495"], "go_terms": ["GO:0000011:vacuole inheritance:P", "GO:0043495:protein-membrane adaptor activity:F"], "name": "Vac17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035296": {"description": "Mating hormone A-factor 1/2", "go_ids": ["GO:0000772"], "go_terms": ["GO:0000772:mating pheromone activity:F"], "name": "Mfa1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035298": {"description": "26S Proteasome non-ATPase regulatory subunit 13", "go_ids": [], "go_terms": [], "name": "PSMD13", "pathway_ids": ["R-HSA-174178", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-HSA-8951664", "R-BTA-9755511", "R-HSA-9010553", "R-HSA-75815", "R-MMU-8948751", "R-SPO-5689880", "R-MMU-5689880", "R-BTA-1169091", "R-DDI-9929491", "R-GGA-68949", "R-BTA-69481", "R-RNO-8854050", "R-HSA-450408", "R-GGA-9766229", "R-RNO-450408", "R-SCE-5689880", "R-HSA-211733", "R-DDI-6798695", "R-DDI-174084", "R-HSA-5607761", "R-GGA-8948751", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-GGA-9931269", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-MMU-9766229", "R-RNO-69481", "R-DDI-187577", "R-BTA-349425", "R-GGA-187577", "R-HSA-174154", "R-RNO-1234176", "R-RNO-5632684", "R-RNO-9932298", "R-DDI-382556", "R-BTA-1236978", "R-MMU-187577", "R-GGA-9755511", "R-RNO-174178", "R-BTA-4608870", "R-BTA-5676590", "R-HSA-9824272", "R-MMU-174178", "R-MMU-349425", "R-GGA-1236978", "R-BTA-2871837", "R-HSA-9907900", "R-BTA-174154", "R-DDI-69601", "R-HSA-9762114", "R-DDI-5689880", "R-HSA-195253", "R-GGA-69601", "R-GGA-9929491", "R-BTA-187577", "R-RNO-9755511", "R-GGA-9020702", "R-RNO-174113", "R-BTA-9929356", "R-GGA-9954709", "R-MMU-5676590", "R-GGA-5689880", "R-RNO-187577", "R-MMU-174184", "R-RNO-68867", "R-RNO-350562", "R-RNO-9762114", "R-GGA-69017", "R-BTA-9954709", "R-RNO-69017", "R-HSA-5358346", "R-SPO-350562", "R-HSA-6798695", "R-MMU-5632684", "R-RNO-9020702", "R-GGA-450408", "R-BTA-5610785", "R-SPO-9907900", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-BTA-6798695", "R-DDI-1236978", "R-DDI-8951664", "R-GGA-382556", "R-GGA-8854050", "R-GGA-9932298", "R-MMU-8951664", "R-RNO-174154", "R-MMU-9929356", "R-SCE-5668541", "R-RNO-9929356", "R-HSA-69481", "R-BTA-174084", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-HSA-4641258", "R-RNO-8939236", "R-SPO-5689603", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-GGA-68867", "R-BTA-4641258", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-RNO-2467813", "R-SPO-6798695", "R-MMU-5610780", "R-BTA-382556", "R-GGA-350562", "R-MMU-9755511", "R-MMU-9954709", "R-DDI-75815", "R-GGA-174154", "R-RNO-5689603", "R-HSA-2871837", "R-RNO-5610780", "R-GGA-8939236", "R-GGA-8939902", "R-HSA-5362768", "R-DDI-9954709", "R-MMU-5658442", "R-RNO-8852276", "R-GGA-5668541", "R-GGA-2467813", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-RNO-9907900", "R-BTA-8948751", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-RNO-8941858", "R-RNO-5607764", "R-RNO-1169091", "R-HSA-69017", "R-BTA-9020702", "R-RNO-9766229", "R-BTA-5607764", "R-DDI-450408", "R-MMU-1236978", "R-GGA-5610780", "R-HSA-202424", "R-GGA-75815", "R-DDI-174154", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-GGA-5689603", "R-HSA-9020702", "R-RNO-8948751", "R-MMU-8941858", "R-HSA-5689880", "R-BTA-1234176", "R-MMU-174154", "R-MMU-69017", "R-MMU-9020702", "R-RNO-382556", "R-RNO-5687128", "R-MMU-69481", "R-BTA-350562", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-HSA-8854050", "R-BTA-5607761", "R-GGA-5658442", "R-HSA-5610783", "R-GGA-5632684", "R-MMU-174084", "R-BTA-68867", "R-HSA-1234176", "R-RNO-4641258", "R-HSA-9931269", "R-MMU-68867", "R-HSA-9929491", "R-RNO-5689880", "R-RNO-8951664", "R-GGA-195253", "R-HSA-1236974", "R-MMU-5687128", "R-RNO-5358346", "R-RNO-6798695", "R-GGA-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-RNO-69601", "R-GGA-8951664", "R-GGA-5607764", "R-GGA-2871837", "R-GGA-5610785", "R-MMU-8939236", "R-RNO-4641257", "R-GGA-8941858", "R-DDI-5689603", "R-GGA-9907900", "R-DDI-2467813", "R-RNO-349425", "R-GGA-349425", "R-BTA-174184", "R-MMU-9762114", "R-MMU-195253", "R-MMU-202424", "R-BTA-8939236", "R-MMU-382556", "R-HSA-5610780", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-MMU-5607761", "R-HSA-8939902", "R-MMU-8939902", "R-GGA-1169091", "R-GGA-9929356", "R-RNO-195253", "R-HSA-8939236", "R-DDI-8854050", "R-BTA-983168", "R-GGA-4608870", "R-MMU-5607764", "R-BTA-5668541", "R-GGA-1234176", "R-GGA-5358346", "R-HSA-9766229", "R-HSA-5676590", "R-DDI-5632684", "R-BTA-9929491", "R-GGA-5687128", "R-HSA-4641257", "R-RNO-202424", "R-BTA-9932298", "R-MMU-9929491", "R-BTA-9762114", "R-HSA-174113", "R-RNO-5607761", "R-GGA-4641257", "R-HSA-68867", "R-MMU-9907900", "R-DDI-5658442", "R-BTA-450408", "R-HSA-8941858", "R-HSA-9755511", "R-RNO-9931269", "R-GGA-6798695", "R-HSA-1169091", "R-GGA-174178", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-HSA-5689603", "R-RNO-983168", "R-GGA-174084", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DDI-9755511", "R-GGA-4641258", "R-BTA-8941858", "R-HSA-349425", "R-HSA-174184", "R-MMU-350562", "R-MMU-69601", "R-BTA-2467813", "R-MMU-5610785", "R-GGA-202424", "R-HSA-9954709", "R-MMU-5358346", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-RNO-1236978", "R-RNO-4608870", "R-HSA-382556", "R-HSA-8852276", "R-GGA-174184", "R-SCE-9907900", "R-DDI-983168", "R-HSA-5668541", "R-HSA-9929356", "R-HSA-5687128", "R-RNO-5658442", "R-RNO-5610785", "R-MMU-983168", "R-GGA-9762114", "R-HSA-350562", "R-DDI-174178"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-68949:r:Orc1 removal from chromatin", "R-BTA-69481:r:G2/M Checkpoints", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-9766229:r:Degradation of CDH1", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-GGA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-GGA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9907900:r:Proteasome assembly", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-9020702:r:Interleukin-1 signaling", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-5689880:r:Ub-specific processing proteases", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-GGA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-GGA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-GGA-382556:r:ABC-family proteins mediated transport", "R-GGA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-GGA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-8951664:r:Neddylation", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-5689603:r:UCH proteinases", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-68867:r:Assembly of the pre-replicative complex", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-GGA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-GGA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-5689603:r:UCH proteinases", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-GGA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-GGA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-9907900:r:Proteasome assembly", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5689603:r:UCH proteinases", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-GGA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-202424:r:Downstream TCR signaling", "R-GGA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-GGA-5689603:r:UCH proteinases", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-GGA-5658442:r:Regulation of RAS by GAPs", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-GGA-5632684:r:Hedgehog 'on' state", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-8951664:r:Neddylation", "R-GGA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-GGA-8951664:r:Neddylation", "R-GGA-5607764:r:CLEC7A (Dectin-1) signaling", "R-GGA-2871837:r:FCERI mediated NF-kB activation", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-4641257:r:Degradation of AXIN", "R-GGA-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-5689603:r:UCH proteinases", "R-GGA-9907900:r:Proteasome assembly", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-GGA-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-GGA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9766229:r:Degradation of CDH1", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-5632684:r:Hedgehog 'on' state", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-GGA-4641257:r:Degradation of AXIN", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5689603:r:UCH proteinases", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-4641258:r:Degradation of DVL", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-GGA-202424:r:Downstream TCR signaling", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-GGA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SCE-9907900:r:Proteasome assembly", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "type": "Family"}, "IPR035300": {"description": "L1 transposable element, dsRBD-like domain", "go_ids": [], "go_terms": [], "name": "L1_dsRBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035301": {"description": "L1 transposable element, trimerization domain", "go_ids": [], "go_terms": [], "name": "L1_trimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035303": {"description": "Protein of unknown function DUF5364", "go_ids": [], "go_terms": [], "name": "DUF5364", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035304": {"description": "Acyl homoserine lactone synthase", "go_ids": ["GO:0009372", "GO:0061579"], "go_terms": ["GO:0009372:quorum sensing:P", "GO:0061579:N-acyl homoserine lactone synthase activity:F"], "name": "AHL_synthase", "pathway_ids": ["PWY-6157"], "pathways": ["PWY-6157:t:autoinducer AI-1 biosynthesis"], "type": "Family"}, "IPR035305": {"description": "Herpesvirus glycoprotein H, C-terminal", "go_ids": [], "go_terms": [], "name": "Herpes_glycoH_C", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Domain"}, "IPR035306": {"description": "Small ribosomal subunit protein uS12m", "go_ids": [], "go_terms": [], "name": "Ribosomal_uS12m", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035307": {"description": "Beta-defensin 136/42", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense response to bacterium:P"], "name": "DEFB136/42", "pathway_ids": ["R-HSA-1461957", "R-MMU-1461973", "R-MMU-1461957", "R-HSA-1461973"], "pathways": ["R-HSA-1461957:r:Beta defensins", "R-MMU-1461973:r:Defensins", "R-MMU-1461957:r:Beta defensins", "R-HSA-1461973:r:Defensins"], "type": "Family"}, "IPR035308": {"description": "Protein of unknown function DUF5368", "go_ids": [], "go_terms": [], "name": "DUF5368", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035309": {"description": "Proteasome activator complex subunit 4", "go_ids": ["GO:0016504", "GO:0070628"], "go_terms": ["GO:0016504:peptidase activator activity:F", "GO:0070628:proteasome binding:F"], "name": "PSME4", "pathway_ids": ["R-HSA-9907900"], "pathways": ["R-HSA-9907900:r:Proteasome assembly"], "type": "Family"}, "IPR035310": {"description": "Galactose/N-acetyl-D-galactosamine lectin light subunit 1", "go_ids": [], "go_terms": [], "name": "Gal_GalNac_light_su_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035311": {"description": "Cystine knot toxin", "go_ids": [], "go_terms": [], "name": "Cys_Knot_tox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035312": {"description": "Satellite RNA 48kDa protein", "go_ids": [], "go_terms": [], "name": "SatRNA_48", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035313": {"description": "Transferrin-binding protein B, N-lobe handle", "go_ids": [], "go_terms": [], "name": "TbpB_N-lobe", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035314": {"description": "Protein of unknown function DUF5370", "go_ids": [], "go_terms": [], "name": "DUF5370", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035315": {"description": "Protein of unknown function DUF5372", "go_ids": [], "go_terms": [], "name": "DUF5372", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035316": {"description": "Transferrin-binding protein B, C-lobe handle domain", "go_ids": [], "go_terms": [], "name": "TbpB_C-lobe", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035317": {"description": "Protein of unknown function DUF5375", "go_ids": [], "go_terms": [], "name": "DUF5375", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035318": {"description": "Protein of unknown function DUF5377", "go_ids": [], "go_terms": [], "name": "DUF5377", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035319": {"description": "Protein of unknown function DUF5378", "go_ids": [], "go_terms": [], "name": "DUF5378", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035321": {"description": "Protein of unknown function DUF5373", "go_ids": [], "go_terms": [], "name": "DUF5373", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035322": {"description": "Male Flower Specific protein 18", "go_ids": [], "go_terms": [], "name": "MFS18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035323": {"description": "Facilitator of iron transport 2", "go_ids": ["GO:0009277", "GO:0015891"], "go_terms": ["GO:0009277:fungal-type cell wall:C", "GO:0015891:siderophore transport:P"], "name": "Fit2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035324": {"description": "Protein of unknown function DUF5381", "go_ids": [], "go_terms": [], "name": "DUF5381", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035325": {"description": "Protein of unknown function DUF5385", "go_ids": [], "go_terms": [], "name": "DUF5385", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035326": {"description": "Phage tail sheath protein-like, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Beta_sandwich_Seath", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035327": {"description": "AlphaC, C-terminal", "go_ids": [], "go_terms": [], "name": "AlphaC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035328": {"description": "DUF3048, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF3048_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035329": {"description": "Rotavirus VP4 helical domain", "go_ids": [], "go_terms": [], "name": "VP4_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035330": {"description": "Rotavirus VP4, membrane interaction domain", "go_ids": [], "go_terms": [], "name": "Rota_VP4_MID", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035331": {"description": "Clostridial binary toxin B/anthrax toxin PA, domain 3", "go_ids": [], "go_terms": [], "name": "Binary_toxB_3", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Domain"}, "IPR035332": {"description": "Protein of unknown function DUF5386", "go_ids": [], "go_terms": [], "name": "DUF5386", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035333": {"description": "Protein of unknown function DUF5389", "go_ids": [], "go_terms": [], "name": "DUF5389", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035334": {"description": "Domain of unknown function DUF5390", "go_ids": [], "go_terms": [], "name": "DUF5390", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035335": {"description": "Protein of unknown function DUF5397", "go_ids": [], "go_terms": [], "name": "DUF5397", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035336": {"description": "Protein of unknown function DUF5398", "go_ids": [], "go_terms": [], "name": "DUF5398", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035337": {"description": "Uncharacterized protein Ycf70-like", "go_ids": [], "go_terms": [], "name": "Ycf70-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035338": {"description": "Protein KleA/KleC-like", "go_ids": [], "go_terms": [], "name": "KleA/KleC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035339": {"description": "Protein of unknown function DUF5426", "go_ids": [], "go_terms": [], "name": "DUF5426", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035340": {"description": "Protein of unknown function DUF5425", "go_ids": [], "go_terms": [], "name": "DUF5425", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035341": {"description": "Gene product 63", "go_ids": [], "go_terms": [], "name": "Gp63", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035342": {"description": "Phage gene product 45.2", "go_ids": [], "go_terms": [], "name": "Gp45.2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035343": {"description": "Gp68-like predicted RNA polymerase component", "go_ids": [], "go_terms": [], "name": "Gp68", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035344": {"description": "Phage gene product 52", "go_ids": [], "go_terms": [], "name": "Gp52", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035345": {"description": "Protein E7, orthopoxvirus", "go_ids": [], "go_terms": [], "name": "E7R_orthopoxvir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035346": {"description": "Protein of unknown function NinD", "go_ids": [], "go_terms": [], "name": "NinD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035347": {"description": "Chemokine-like protein U83", "go_ids": [], "go_terms": [], "name": "Putative_chemo_U83", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035348": {"description": "MoaF, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MoaF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035349": {"description": "Meiotic recombination protein Rec104", "go_ids": ["GO:0042138"], "go_terms": ["GO:0042138:meiotic DNA double-strand break formation:P"], "name": "Rec104", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035350": {"description": "Protein of unknown function DUF5400", "go_ids": [], "go_terms": [], "name": "DUF5400", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035351": {"description": "Non-structural protein 11/12", "go_ids": [], "go_terms": [], "name": "Pns11/12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035352": {"description": "TSX", "go_ids": [], "go_terms": [], "name": "TSX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035353": {"description": "Gene product 79", "go_ids": [], "go_terms": [], "name": "Gp79", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035354": {"description": "Protein of unknown function DUF5424", "go_ids": [], "go_terms": [], "name": "DUF5424", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035355": {"description": "Protein of unknown function DUF5423", "go_ids": [], "go_terms": [], "name": "DUF5423", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035356": {"description": "Lacto-N-biose phosphorylase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LBP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035358": {"description": "Protein of unknown function DUF5422", "go_ids": [], "go_terms": [], "name": "DUF5422", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035359": {"description": "Protein of unknown function DUF5421", "go_ids": [], "go_terms": [], "name": "DUF5421", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035360": {"description": "Protein of unknown function DUF5420", "go_ids": [], "go_terms": [], "name": "DUF5420", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035361": {"description": "Honey bee toxin", "go_ids": [], "go_terms": [], "name": "Bee_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035362": {"description": "Protein KleE", "go_ids": [], "go_terms": [], "name": "KleE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035363": {"description": "Lacto-N-biose phosphorylase, central domain", "go_ids": [], "go_terms": [], "name": "LBP_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035364": {"description": "Glycosyl hydrolase 101, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Beta_sandwich_GH101", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035365": {"description": "Protein of unknown function DUF5407", "go_ids": [], "go_terms": [], "name": "DUF5407", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035366": {"description": "Protein of unknown function DUF5408", "go_ids": [], "go_terms": [], "name": "DUF5408", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035367": {"description": "Nrap protein, domain 2", "go_ids": [], "go_terms": [], "name": "Nrap_D2", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR035368": {"description": "Nrap protein, domain 3", "go_ids": [], "go_terms": [], "name": "Nrap_D3", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR035369": {"description": "Nrap protein, domain 4", "go_ids": [], "go_terms": [], "name": "Nrap_D4", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR035370": {"description": "Nrap protein, domain 5", "go_ids": [], "go_terms": [], "name": "Nrap_D5", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR035371": {"description": "Nrap protein, domain 6", "go_ids": [], "go_terms": [], "name": "Nrap_D6", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR035372": {"description": "Malonyl-CoA decarboxylase, N-terminal", "go_ids": [], "go_terms": [], "name": "MCD_N", "pathway_ids": ["PWY-7485", "PWY-8358", "R-RNO-390247", "R-RNO-9033241", "R-MMU-9033241", "R-HSA-9033241", "R-HSA-390247", "R-MMU-390247"], "pathways": ["PWY-7485:t:tetracenomycin C biosynthesis", "PWY-8358:t:curacin A biosynthesis", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR035373": {"description": "Alpha galactosidase A, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Melibiase/NAGA_C", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-MMU-9840310", "R-HSA-9840310"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Domain"}, "IPR035374": {"description": "Protein VraX", "go_ids": [], "go_terms": [], "name": "VraX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035375": {"description": "MatP, C-terminal ribbon-helix-helix domain", "go_ids": [], "go_terms": [], "name": "MatP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035376": {"description": "NigD-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NigD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035377": {"description": "Herpesvirus Glycoprotein B, PH-like domain 1", "go_ids": [], "go_terms": [], "name": "Glycoprot_B_PH1", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Domain"}, "IPR035378": {"description": "Uncharacterized protein YrzK-like", "go_ids": [], "go_terms": [], "name": "YrzK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035379": {"description": "Uncharacterized protein YkpC-like", "go_ids": [], "go_terms": [], "name": "YkpC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035380": {"description": "Late transcription unit A", "go_ids": [], "go_terms": [], "name": "LtuA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035381": {"description": "Herpesvirus Glycoprotein B, PH-like domain 2", "go_ids": [], "go_terms": [], "name": "Glycoprot_B_PH2", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Domain"}, "IPR035382": {"description": "Mating factor A1", "go_ids": [], "go_terms": [], "name": "MFA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035383": {"description": "Methylamine utilization protein MauJ, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MauJ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035384": {"description": "Uncharacterized protein YhdX-like", "go_ids": [], "go_terms": [], "name": "YhdX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035385": {"description": "Herpesvirus U62/UL91, functional domain", "go_ids": [], "go_terms": [], "name": "U62/UL91", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Domain"}, "IPR035386": {"description": "Arm, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "Arm-DNA-bind_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035387": {"description": "Protein of unknown function DUF5406", "go_ids": [], "go_terms": [], "name": "DUF5406", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035388": {"description": "Swarming motility protein SwrA", "go_ids": [], "go_terms": [], "name": "SwrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035389": {"description": "Protein of unknown function DUF5411", "go_ids": [], "go_terms": [], "name": "DUF5411", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035390": {"description": "Thiol-activated cytolysin C-terminal", "go_ids": [], "go_terms": [], "name": "Thiol_cytolys_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035391": {"description": "Arylsulfotransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Arylsulfotran_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035392": {"description": "Protein of unknown function DUF5417", "go_ids": [], "go_terms": [], "name": "DUF5417", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035393": {"description": "Protein of unknown function DUF5416", "go_ids": [], "go_terms": [], "name": "DUF5416", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035394": {"description": "Glycosyl hydrolase family 59, central domain", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_59_dom", "pathway_ids": ["R-MMU-9840310", "R-CEL-9840310", "R-HSA-9840310"], "pathways": ["R-MMU-9840310:r:Glycosphingolipid catabolism", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Domain"}, "IPR035395": {"description": "Protein of unknown function DUF5415", "go_ids": [], "go_terms": [], "name": "DUF5415", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035396": {"description": "Alpha-L-rhamnosidase, six-hairpin glycosidase domain", "go_ids": [], "go_terms": [], "name": "Bac_rhamnosid6H", "pathway_ids": ["PWY-7134"], "pathways": ["PWY-7134:t:rutin degradation (plants)"], "type": "Domain"}, "IPR035397": {"description": "CT_584-like", "go_ids": [], "go_terms": [], "name": "CT_584-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035398": {"description": "Alpha-L-rhamnosidase C-terminal domain", "go_ids": [], "go_terms": [], "name": "Bac_rhamnosid_C", "pathway_ids": ["PWY-7134"], "pathways": ["PWY-7134:t:rutin degradation (plants)"], "type": "Domain"}, "IPR035399": {"description": "Protein of unknown function DUF5413", "go_ids": [], "go_terms": [], "name": "DUF5413", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035400": {"description": "Urocanase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Urocanase_N", "pathway_ids": ["PWY-5030", "PWY-5028", "R-MMU-70921", "R-CEL-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5028:t:L-histidine degradation II", "R-MMU-70921:r:Histidine catabolism", "R-CEL-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Domain"}, "IPR035401": {"description": "Urocanase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Urocanase_C", "pathway_ids": ["PWY-5030", "PWY-5028", "R-MMU-70921", "R-CEL-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5028:t:L-histidine degradation II", "R-MMU-70921:r:Histidine catabolism", "R-CEL-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Domain"}, "IPR035402": {"description": "D-glutamate N-acetyltransferase-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DgcN-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035403": {"description": "Uncharacterized protein YmpT-like", "go_ids": [], "go_terms": [], "name": "YmpT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035404": {"description": "Domain of unknown function DUF5405", "go_ids": [], "go_terms": [], "name": "DUF5405", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035405": {"description": "Gene product 70", "go_ids": [], "go_terms": [], "name": "GP70", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035406": {"description": "Protein of unknown function DUF5412", "go_ids": [], "go_terms": [], "name": "DUF5412", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035407": {"description": "Protein of unknown function DUF5399", "go_ids": [], "go_terms": [], "name": "DUF5399", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035408": {"description": "Phage single-stranded DNA-binding protein", "go_ids": [], "go_terms": [], "name": "Phi29_Phage_SSB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035409": {"description": "Seminal vesicle secretory protein 4/5/6", "go_ids": [], "go_terms": [], "name": "Svs4/5/6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035411": {"description": "Putative DNA-Binding protein G5P", "go_ids": [], "go_terms": [], "name": "Putative_G5P", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035412": {"description": "Phage terminase large subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "Terminase_L_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035413": {"description": "Phage terminase large subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "Terminase_L_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035414": {"description": "Peptidase M1, alanyl aminopeptidase, Ig-like fold", "go_ids": [], "go_terms": [], "name": "Peptidase_M1_pepN_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035415": {"description": "DUF5382, central domain", "go_ids": [], "go_terms": [], "name": "DUF5382_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035416": {"description": "Protein of unknown function DUF5376", "go_ids": [], "go_terms": [], "name": "DUF5376", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035417": {"description": "FACT complex subunit SSRP1/POB3, N-terminal PH domain", "go_ids": [], "go_terms": [], "name": "SSRP1/POB3_N", "pathway_ids": ["R-SPO-674695", "R-RNO-674695", "R-HSA-167238", "R-MMU-6804756", "R-DME-6796648", "R-SCE-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-DDI-674695", "R-HSA-167152", "R-DDI-6796648", "R-DDI-6804756", "R-CEL-6804756", "R-RNO-6804756", "R-SPO-6796648", "R-SCE-6796648", "R-CEL-75955", "R-MMU-6796648", "R-DME-674695", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-HSA-6804756", "R-HSA-167290", "R-RNO-112382", "R-CEL-112382", "R-HSA-75955", "R-SCE-674695", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR035418": {"description": "Transcription regulator HTH, AraC- type, ligand binding domain-like", "go_ids": [], "go_terms": [], "name": "AraC-bd_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035420": {"description": "Spt6, SH2 domain", "go_ids": [], "go_terms": [], "name": "Spt6_SH2", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Domain"}, "IPR035421": {"description": "Terminase, large subunit gp17-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Terminase_6C", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR035422": {"description": "Alginate O-acetyl transferase AlgF", "go_ids": ["GO:0042121"], "go_terms": ["GO:0042121:alginic acid biosynthetic process:P"], "name": "AlgF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035423": {"description": "M60-like domain, N-terminal", "go_ids": [], "go_terms": [], "name": "M60-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035424": {"description": "Antitoxin of toxin-antitoxin, RelE/RelB, TA system", "go_ids": [], "go_terms": [], "name": 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hepatic steatosis", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-GGA-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-RNO-9909649:r:Regulation of PD-L1(CD274) transcription", "R-SSC-2299718:r:Condensation of Prophase Chromosomes", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-SSC-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-GGA-427413:r:NoRC negatively regulates rRNA expression"], "type": "Domain"}, "IPR035426": {"description": "Gemin2/Brr1", "go_ids": ["GO:0000387"], "go_terms": ["GO:0000387:spliceosomal snRNP assembly:P"], "name": "Gemin2/Brr1", "pathway_ids": ["R-HSA-9754678", "R-MMU-191859", "R-RNO-191859", "R-HSA-191859"], "pathways": ["R-HSA-9754678:r:SARS-CoV-2 modulates host translation 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"R-DME-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-210747:r:Regulation of gene expression in early pancreatic precursor cells", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-DRE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-8939211:r:ESR-mediated signaling", "R-DRE-200425:r:Carnitine shuttle", "R-DME-383280:r:Nuclear Receptor transcription pathway", "R-SSC-4090294:r:SUMOylation of intracellular receptors", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DRE-5362517:r:Signaling by Retinoic Acid", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-159418:r:Recycling of bile acids and salts", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-BTA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-SSC-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-CFA-383280:r:Nuclear Receptor transcription pathway", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-211976:r:Endogenous sterols", "R-MMU-9616222:r:Transcriptional regulation of granulopoiesis", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-DRE-383280:r:Nuclear Receptor transcription pathway", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DRE-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-RNO-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-211976:r:Endogenous sterols", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-CEL-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DRE-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-SSC-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-BTA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-198693:r:AKT phosphorylates targets in the nucleus", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-HSA-8849473:r:PTK6 Expression", "R-RNO-200425:r:Carnitine shuttle", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-SSC-5689880:r:Ub-specific processing proteases", "R-SSC-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-DME-4090294:r:SUMOylation of intracellular receptors", "R-DRE-8939211:r:ESR-mediated signaling", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-DME-159418:r:Recycling of bile acids and salts", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-RNO-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-SSC-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-BTA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-GGA-383280:r:Nuclear Receptor transcription pathway", "R-SSC-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SSC-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-9831926:r:Nephron development", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-RNO-8939211:r:ESR-mediated signaling", "R-MMU-159418:r:Recycling of bile acids and salts", "R-DME-5362517:r:Signaling by Retinoic Acid"], "type": "Homologous_superfamily"}, "IPR035504": {"description": "MUM1-like, PWWP domain", "go_ids": [], "go_terms": [], "name": "MUM1-like_PWWP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035506": {"description": "Pollen allergen/Uncharacterized protein Os", "go_ids": [], "go_terms": [], "name": "Pollen_allergen/Os", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035513": {"description": "Invertase/pectin methylesterase inhibitor domain superfamily", "go_ids": [], "go_terms": [], "name": "Invertase/methylesterase_inhib", "pathway_ids": ["PWY-7246", "PWY-7248"], "pathways": ["PWY-7246:t:pectin degradation I", "PWY-7248:t:pectin degradation II"], "type": "Homologous_superfamily"}, "IPR035516": {"description": "DNA gyrase/topoisomerase IV, subunit A, C-terminal", "go_ids": [], "go_terms": [], "name": "Gyrase/topoIV_suA_C", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638771"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638771:r:Action of antimicrobials"], "type": "Homologous_superfamily"}, "IPR035520": {"description": "High-affinity zinc uptake system protein ZnuA", "go_ids": ["GO:0006829", "GO:0046872"], "go_terms": ["GO:0006829:zinc ion transport:P", "GO:0046872:metal ion binding:F"], "name": "ZnuA", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR035528": {"description": "Protein of unknown function DUF5388", "go_ids": [], "go_terms": [], "name": "DUF5388", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035530": {"description": "Phage-like element PBSX protein XtrA", "go_ids": [], "go_terms": [], "name": "PBSX_XtrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035539": {"description": "Protein of unknown function DUF5387", "go_ids": [], "go_terms": [], "name": "DUF5387", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035542": {"description": "Cyclophilin-RNA interacting protein", "go_ids": [], "go_terms": [], "name": "CRIP", "pathway_ids": ["R-HSA-72163", "R-CEL-72163", "R-SPO-72163", "R-HSA-9918481", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR035545": {"description": "Outer membrane lipoprotein virB7", "go_ids": [], "go_terms": [], "name": "VirB7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035566": {"description": "Ribosomal protein bL20, C-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_protein_bL20_C", "pathway_ids": ["R-MMU-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Homologous_superfamily"}, "IPR035569": {"description": "Antitoxin epsilon/PezA domain superfamily", "go_ids": [], "go_terms": [], "name": "Antitoxin_epsilon/PezA_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035570": {"description": "UPF0234, N-terminal", "go_ids": [], "go_terms": [], "name": "UPF0234_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035571": {"description": "UPF0234-like, C-terminal", "go_ids": [], "go_terms": [], "name": "UPF0234-like_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035576": {"description": "Type VI secretion system TssC", "go_ids": ["GO:0033104", "GO:0033103"], "go_terms": ["GO:0033104:type VI protein secretion system complex:C", "GO:0033103:protein secretion by the type VI secretion system:P"], "name": "T6SS_TssC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035578": {"description": "Styelin", "go_ids": [], "go_terms": [], "name": "Styelin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035581": {"description": "Domain of unknown function DUF5465", "go_ids": [], "go_terms": [], "name": "DUF5465", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR035582": {"description": "Protein of unknown function DUF5418", "go_ids": [], "go_terms": [], "name": "DUF5418", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035587": {"description": "DUS-like, FMN-binding domain", "go_ids": [], "go_terms": [], "name": "DUS-like_FMN-bd", "pathway_ids": ["PWY-6309", "PWY-8382", "PWY-7655", "PWY-5292", "PWY-7096", "PWY-7300", "PWY-8374", "PWY-5956", "PWY-8103", "PWY-6302", "PWY-6996", "PWY-7881", "PWY-6824", "PWY-7154", "PWY-5367", "PWY-8152", "PWY-5984", "PWY-5393", "PWY-5972", "PWY-6944", "PWY-7770", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-6332", "PWY-7846", "PWY-6088", "PWY-7155", "PWY-8044", "PWY-6786", "PWY-7653", "PWY-2541", "PWY-5818", "PWY-7826", "R-HSA-6782315", "R-MMU-9833482", "R-HSA-9833482"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-7096:t:triclosan resistance", "PWY-7300:t:ecdysone and 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"R-MMU-5419276:r:Mitochondrial translation termination", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR035684": {"description": "Arginyl-tRNA synthetase, catalytic core domain", "go_ids": [], "go_terms": [], "name": "ArgRS_core", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-HSA-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-HSA-379716", "R-RNO-9856649", "R-DME-9856649"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Domain"}, "IPR035699": {"description": "Dynein heavy chain, hydrolytic ATP-binding dynein motor region", "go_ids": ["GO:0005524"], "go_terms": ["GO:0005524:ATP binding:F"], "name": "Dhc_AAA", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR035706": {"description": "Dynein heavy chain, ATP-binding dynein motor region", "go_ids": [], "go_terms": [], "name": "AAA_9", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR035709": {"description": "RutC family, YoaB-like", "go_ids": [], "go_terms": [], "name": "YoaB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035712": {"description": "TRADD", "go_ids": [], "go_terms": [], "name": "TRADD", "pathway_ids": ["R-BTA-69416", "R-DRE-5675482", "R-MMU-5357786", "R-HSA-5218900", "R-BTA-5357905", "R-BTA-5218900", "R-DRE-75893", "R-DRE-5357956", "R-BTA-5357956", "R-BTA-5357786", "R-HSA-5675482", "R-MMU-5675482", "R-DRE-3371378", "R-HSA-75893", "R-MMU-5357956", "R-HSA-5357786", "R-HSA-69416", "R-DRE-5218900", "R-HSA-5213460", "R-MMU-69416", "R-DRE-5357905", "R-HSA-5357905", "R-BTA-75893", "R-HSA-5357956", "R-BTA-5675482", "R-HSA-9693928", "R-MMU-5357905", "R-MMU-3371378", "R-BTA-3371378", "R-MMU-5218900", "R-HSA-140534", "R-DRE-5357786", "R-HSA-3371378", "R-DRE-69416", "R-MMU-75893"], "pathways": ["R-BTA-69416:r:Dimerization of procaspase-8", "R-DRE-5675482:r:Regulation of necroptotic cell death", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-5218900:r:CASP8 activity is inhibited", "R-DRE-75893:r:TNF signaling", "R-DRE-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-3371378:r:Regulation by c-FLIP", "R-HSA-75893:r:TNF signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-69416:r:Dimerization of procaspase-8", "R-DRE-5218900:r:CASP8 activity is inhibited", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-69416:r:Dimerization of procaspase-8", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-75893:r:TNF signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-3371378:r:Regulation by c-FLIP", "R-BTA-3371378:r:Regulation by c-FLIP", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DRE-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-3371378:r:Regulation by c-FLIP", "R-DRE-69416:r:Dimerization of procaspase-8", "R-MMU-75893:r:TNF signaling"], "type": "Family"}, "IPR035714": {"description": "RAG1 importin-binding", "go_ids": [], "go_terms": [], "name": "RAG1_imp-bd", "pathway_ids": ["PWY-7511", "R-HSA-1266695", "R-HSA-5687128"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Domain"}, "IPR035715": {"description": "Metallothionein-like protein Crs5", "go_ids": [], "go_terms": [], "name": "Crs5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035766": {"description": "SPRY domain-containing protein 7", "go_ids": [], "go_terms": [], "name": "SPRYD7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035810": {"description": "Phosphatidylethanolamine-binding protein, eukaryotic", "go_ids": [], "go_terms": [], "name": "PEBP_euk", "pathway_ids": ["R-DME-5674135", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-RNO-5389840", "R-CEL-5675221", "R-HSA-6802952", "R-MMU-9937383", "R-HSA-5419276", "R-HSA-9937383", "R-RNO-5675221", "R-CEL-5674135", "R-BTA-9937383", "R-MMU-5389840", "R-CFA-5675221", "R-DME-5675221", "R-BTA-5675221", "R-BTA-5674135", "R-BTA-5389840", "R-RNO-5419276", "R-HSA-6802946", "R-HSA-9649948", "R-CFA-5674135", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-RNO-5674135", "R-RNO-9937383", "R-HSA-5389840", "R-HSA-6802955", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-DME-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-CFA-5675221:r:Negative regulation of MAPK pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CFA-5674135:r:MAP2K and MAPK activation", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR035848": {"description": "SH3 domain-binding protein 2", "go_ids": ["GO:0007165"], "go_terms": ["GO:0007165:signal transduction:P"], "name": "SH3BP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR035889": {"description": "Light-harvesting complex", "go_ids": [], "go_terms": [], "name": "Light-harvesting_complex", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035890": {"description": "Anti-sigma-28 factor FlgM superfamily", "go_ids": [], "go_terms": [], "name": "Anti-sigma-28_factor_FlgM_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035891": {"description": "CheY-binding domain of CheA", "go_ids": [], "go_terms": [], "name": "CheY-binding_CheA", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035892": {"description": "C2 domain superfamily", "go_ids": [], "go_terms": [], "name": "C2_domain_sf", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-DDI-114604", "R-XTR-1482801", "R-CEL-72165", "R-MMU-5654720", "R-HSA-8936459", "R-HSA-2871796", "R-BTA-1483206", "R-MMU-1632852", "R-MMU-181430", "R-SPO-165181", "R-HSA-9010642", "R-DDI-72163", "R-RNO-512988", "R-CEL-5654219", "R-RNO-2871809", "R-HSA-9668328", "R-MMU-5654221", "R-HSA-5654695", "R-DDI-202424", "R-MMU-5689880", "R-MMU-201556", "R-HSA-76005", "R-HSA-432040", "R-SCE-8980692", "R-HSA-9662360", "R-BTA-6811558", "R-SCE-1660517", "R-MMU-5610787", "R-HSA-512988", "R-HSA-8875513", "R-RNO-416476", "R-DRE-201451", "R-SCE-165158", "R-SCE-9696273", "R-DDI-399997", "R-DDI-6798695", "R-DME-4641257", "R-SPO-6811558", "R-MMU-112043", "R-HSA-373752", "R-HSA-162588", "R-GGA-1483166", "R-BTA-500657", "R-SCE-1489509", "R-HSA-72163", "R-SCE-1632852", "R-CEL-112043", "R-DME-112043", "R-CEL-1433557", "R-RNO-5654228", "R-DRE-8980692", "R-XTR-2142753", "R-SCE-389513", "R-MMU-1250196", "R-DDI-1660514", "R-RNO-1483206", "R-RNO-2871796", "R-BTA-1660499", "R-HSA-202433", "R-MMU-2142753", "R-HSA-201451", "R-CEL-210500", "R-DME-111933", "R-XTR-4419969", "R-CEL-5654227", "R-SCE-76005", "R-DME-2028269", "R-MMU-9034793", "R-RNO-168138", "R-SPO-114516", "R-HSA-114608", "R-HSA-500657", "R-BTA-9927354", "R-CEL-5654221", "R-MMU-2672351", "R-HSA-9013148", "R-HSA-1963642", "R-RNO-8856828", "R-HSA-1483206", "R-SCE-4419969", "R-CEL-72163", "R-MMU-5621480", "R-RNO-434316", "R-HSA-6811436", "R-DDI-5689880", "R-DDI-5628897", "R-DDI-1474151", "R-MMU-114516", "R-DME-2179392", "R-DRE-111995", "R-MMU-5675482", "R-DRE-2173788", "R-MMU-210500", "R-RNO-5654689", "R-HSA-1482798", "R-BTA-416482", "R-RNO-9013423", "R-DRE-983231", "R-GGA-888590", "R-HSA-983170", "R-HSA-9009391", "R-HSA-9717207", "R-SPO-2871837", "R-DDI-4419969", "R-CEL-5218921", "R-MMU-8851907", "R-MMU-9032759", "R-BTA-210993", "R-HSA-9027277", "R-BTA-1482922", "R-BTA-181429", "R-SPO-1660517", "R-HSA-9725370", "R-DRE-418592", "R-HSA-5668599", "R-SPO-202433", "R-CEL-2029485", "R-MMU-416476", "R-HSA-6798695", "R-DDI-5218921", "R-CEL-210993", "R-MMU-5632684", "R-HSA-8875555", "R-RNO-9020702", "R-MMU-1660516", "R-CEL-6798695", "R-SCE-1660514", "R-MMU-2173791", "R-BTA-1482801", "R-BTA-6798695", "R-CEL-9013409", "R-SCE-389357", "R-MMU-4420097", "R-HSA-9670439", "R-SPO-76005", "R-SPO-1855204", "R-SPO-198323", "R-RNO-912526", "R-MMU-432142", "R-SCE-6811558", "R-RNO-198203", "R-RNO-212676", "R-MMU-9954716", "R-CEL-2871837", "R-DDI-5675482", "R-SPO-9009391", "R-MMU-392451", "R-BTA-8853659", "R-DDI-9841251", "R-DME-8948747", "R-MMU-2029485", "R-RNO-9013404", "R-BTA-112399", "R-HSA-9013408", "R-MMU-434316", "R-HSA-5654221", "R-CEL-9668328", "R-RNO-1482839", "R-RNO-1482801", "R-RNO-9927354", "R-DRE-5099900", "R-RNO-432722", "R-MMU-1474228", "R-DDI-8948751", "R-HSA-5675482", "R-RNO-1482922", "R-HSA-264642", "R-DRE-1482925", "R-DME-450520", "R-XTR-6798695", "R-HSA-1660516", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-CEL-212718", "R-MMU-418217", "R-DDI-9856530", "R-DME-1250196", "R-MMU-76005", "R-DDI-5625740", "R-HSA-1632852", "R-MMU-8875513", "R-DME-76005", "R-HSA-1257604", "R-MMU-5654710", "R-SPO-1632852", "R-RNO-9668328", "R-DME-8941858", "R-SPO-6798695", "R-MMU-2179392", "R-DME-416993", "R-RNO-114516", "R-MMU-9856530", "R-MMU-9648002", "R-DDI-8948747", "R-BTA-416993", "R-DDI-2871837", "R-CEL-5668599", "R-MMU-9013148", "R-HSA-1251932", "R-CEL-416476", "R-XTR-5668599", "R-HSA-6794361", "R-CFA-5689880", "R-MMU-198203", "R-DDI-76005", "R-MMU-8875555", "R-RNO-114608", "R-HSA-9673770", "R-HSA-114508", "R-BTA-201556", "R-HSA-1482922", "R-DDI-1169091", "R-MMU-9824585", "R-HSA-9035034", "R-DME-9013409", "R-MMU-5658442", "R-MMU-168638", "R-SCE-983168", "R-CEL-5654710", "R-MMU-4608870", "R-MMU-5218921", "R-SPO-9856530", "R-BTA-2029485", "R-HSA-9694676", "R-CEL-202433", "R-RNO-8856825", "R-DDI-3295583", "R-RNO-9034793", "R-MMU-500657", "R-BTA-434316", "R-RNO-2142753", "R-SCE-114516", "R-DDI-1257604", "R-SPO-4419969", "R-DRE-5625740", "R-XTR-111995", "R-HSA-2142753", "R-DRE-4419969", "R-HSA-983168", "R-DRE-1482922", "R-MMU-1169408", "R-MMU-2029482", "R-HSA-186763", "R-BTA-8856825", "R-HSA-111995", "R-DME-3000170", "R-RNO-2424491", "R-RNO-1169091", "R-SCE-114508", "R-BTA-9020702", "R-HSA-5654710", "R-BTA-4419969", "R-HSA-9692916", "R-MMU-3928662", "R-CEL-399997", "R-HSA-9013406", "R-BTA-418217", "R-HSA-202424", "R-DME-9013423", "R-RNO-2871837", "R-MMU-2173795", "R-XTR-76005", "R-SCE-399997", "R-HSA-9607240", "R-DDI-5689896", "R-RNO-8948751", "R-DRE-1169091", "R-HSA-9020702", "R-HSA-168638", "R-MMU-8941858", "R-MMU-114604", "R-RNO-111995", "R-CEL-1660514", "R-DME-2173788", "R-HSA-167021", "R-RNO-9607240", "R-RNO-202433", "R-DME-5658442", "R-CEL-114516", "R-MMU-9009391", "R-DDI-2179392", "R-MMU-9013409", "R-MMU-9020702", "R-MMU-5689896", "R-MMU-3000170", "R-CEL-5654695", "R-DME-9013148", "R-RNO-1632852", "R-XTR-114516", "R-RNO-6811558", "R-RNO-210990", "R-CEL-1257604", "R-DME-1855204", "R-RNO-1963642", "R-HSA-9603381", "R-HSA-199418", "R-MMU-1489509", "R-SPO-9634635", "R-HSA-114604", "R-DME-1433559", "R-HSA-1474228", "R-DME-9013149", "R-CEL-1855204", "R-HSA-5654689", "R-HSA-418592", "R-HSA-983231", "R-GGA-181430", "R-GGA-1483115", "R-DME-1253288", "R-MMU-1482839", "R-RNO-112043", "R-RNO-5689880", "R-MMU-432040", "R-DDI-392451", "R-MMU-9013423", "R-DRE-1483166", "R-HSA-1433559", "R-CEL-418597", "R-HSA-418597", "R-BTA-2142753", "R-HSA-8986944", "R-DRE-4608870", "R-HSA-9648002", "R-BTA-2424491", "R-RNO-6798695", "R-HSA-9768919", "R-HSA-1482788", "R-CEL-1660516", "R-HSA-9954716", "R-SCE-2179392", "R-RNO-9842663", "R-HSA-9705671", "R-RNO-9035034", "R-DDI-199418", "R-GGA-1482798", "R-HSA-2672351", "R-HSA-9665348", "R-BTA-9013148", "R-DME-5625740", "R-HSA-1483166", "R-RNO-1253288", "R-BTA-9013423", "R-SPO-9013406", "R-HSA-181429", "R-BTA-5654695", "R-GGA-111995", "R-MMU-9013507", "R-CEL-111933", "R-HSA-9028335", "R-RNO-1482925", "R-HSA-72165", "R-HSA-2730905", "R-GGA-212676", "R-MMU-111465", "R-BTA-1433557", "R-BTA-512988", "R-BTA-264642", "R-DRE-114516", "R-CEL-9013423", "R-HSA-5610780", "R-HSA-416993", "R-MMU-912631", "R-SPO-114508", "R-BTA-9954716", "R-HSA-418217", "R-RNO-181430", "R-SPO-1169091", "R-BTA-9009391", "R-SCE-9013106", "R-HSA-8939902", "R-SCE-5218921", "R-RNO-1660499", "R-MMU-72165", "R-BTA-9013404", "R-HSA-877300", "R-BTA-1257604", "R-CEL-9013420", "R-CEL-9009391", "R-HSA-9856530", "R-RNO-5654219", "R-BTA-9607240", "R-MMU-9013149", "R-RNO-3000170", "R-MMU-373752", "R-CEL-1250342", "R-DME-9856530", "R-XTR-1482925", "R-BTA-389357", "R-DDI-2028269", "R-DME-9013420", "R-RNO-1482798", "R-GGA-1482839", "R-DRE-1855204", "R-CEL-1253288", "R-SCE-2029485", "R-HSA-432142", "R-RNO-9013149", "R-HSA-2179392", "R-DRE-5218921", "R-MMU-9013404", "R-HSA-3928662", "R-CEL-9035034", "R-MMU-2871796", "R-RNO-112399", "R-RNO-1482788", "R-DME-9035034", "R-RNO-2029485", "R-RNO-9954716", "R-RNO-5625740", "R-RNO-2179392", "R-HSA-164944", "R-RNO-9026527", "R-HSA-9609523", "R-HSA-9664565", "R-CEL-264642", "R-DRE-9013106", "R-DME-8980692", "R-DME-210500", "R-HSA-2514859", "R-DRE-432142", "R-DDI-5658442", "R-BTA-432142", "R-HSA-8941858", "R-MMU-8853659", "R-CEL-76005", "R-HSA-2219530", "R-MMU-450520", "R-BTA-888590", "R-DRE-1482788", "R-CEL-202424", "R-BTA-111995", "R-HSA-9013404", "R-MMU-264642", "R-HSA-9703648", "R-MMU-2871837", "R-DME-72165", "R-RNO-264642", "R-BTA-418592", "R-HSA-5250958", "R-SCE-203615", "R-RNO-4419969", "R-SPO-8948751", "R-RNO-983168", "R-HSA-198203", "R-HSA-9679504", "R-RNO-4420097", "R-MMU-2028269", "R-HSA-114516", "R-DME-2122948", "R-DME-1169091", "R-GGA-418592", "R-MMU-8856825", "R-MMU-432722", "R-RNO-111933", "R-DDI-8849471", "R-DDI-198323", "R-HSA-936440", "R-BTA-114516", "R-HSA-1169408", "R-HSA-1250342", "R-HSA-418885", "R-HSA-399997", "R-HSA-5628897", "R-CEL-9013149", "R-DME-888590", "R-XTR-5620912", "R-SCE-9634635", "R-HSA-112043", "R-SCE-9013406", "R-BTA-212676", "R-DRE-1482839", "R-RNO-5625886", "R-SPO-114604", "R-SPO-983168", "R-DDI-389513", "R-MMU-1855183", "R-MMU-432720", "R-MMU-1482925", "R-HSA-9920951", "R-MMU-1855204", "R-RNO-373752", "R-HSA-9918481", "R-RNO-9648002", "R-CFA-202424", "R-XTR-1482839", "R-DDI-1169408", "R-DME-8856825", "R-DRE-5689880", "R-HSA-9013420", "R-HSA-9013508", "R-HSA-8948747", "R-BTA-1250342", "R-HSA-9679191", "R-MMU-983695", "R-RNO-180292", "R-HSA-1433557", "R-MMU-877300", "R-MMU-9013106", "R-CEL-418594", "R-MMU-112399", "R-SPO-203615", "R-RNO-114604", "R-HSA-9703465", "R-HSA-418594", "R-BTA-5218921", "R-GGA-2142753", "R-MMU-2871809", "R-RNO-5658442", "R-MMU-9013026", "R-DDI-434316", "R-CEL-1963642", "R-MMU-983168", "R-DDI-389357", "R-MMU-4419969", "R-RNO-1250196", "R-DRE-6811436", "R-RNO-888590", "R-MMU-9026527", "R-HSA-9842640", "R-MMU-1250342", "R-MMU-8856828", "R-RNO-418592", "R-DDI-114516", "R-BTA-1483115", "R-BTA-5625886", "R-CEL-181430", "R-BTA-198203", "R-MMU-6811558", "R-MMU-9668328", "R-BTA-5673001", "R-GGA-181429", "R-HSA-912631", "R-BTA-8851907", "R-SCE-9841251", "R-RNO-72163", "R-DME-72163", "R-MMU-8948751", "R-DME-8948751", "R-DRE-8941858", "R-BTA-5654710", "R-RNO-912631", "R-SCE-198323", "R-DDI-1855204", "R-BTA-4420097", "R-XTR-1483115", "R-BTA-1169091", "R-DDI-983695", "R-DDI-2029485", "R-DME-2029485", "R-HSA-9013507", "R-RNO-193648", "R-MMU-186763", "R-MMU-8849471", "R-DDI-9634635", "R-MMU-9035034", "R-HSA-168138", "R-HSA-983695", "R-BTA-5099900", "R-HSA-432720", "R-DME-5625886", "R-MMU-8948747", "R-RNO-9013148", "R-SCE-1474151", "R-GGA-9954716", "R-CEL-212676", "R-XTR-1482798", "R-MMU-4641258", "R-MMU-912526", "R-BTA-6811436", "R-HSA-5674404", "R-DDI-5674135", "R-MMU-5654219", "R-SPO-9841251", "R-RNO-2730905", "R-HSA-1855204", "R-MMU-399997", "R-DRE-9013026", "R-BTA-8980692", "R-HSA-389357", "R-HSA-1482839", "R-MMU-1963642", "R-CEL-6811558", "R-CEL-8948751", "R-BTA-5654689", "R-HSA-9680350", "R-MMU-5654227", "R-SCE-114604", "R-DDI-9009391", "R-RNO-1257604", "R-RNO-8980692", "R-HSA-5625740", "R-CEL-5654720", "R-DRE-4641257", "R-CEL-2179392", "R-RNO-1489509", "R-HSA-1482925", "R-HSA-5625886", "R-SPO-5625740", "R-DRE-983168", "R-BTA-4086398", "R-RNO-416482", "R-HSA-2173795", "R-BTA-76005", "R-RNO-3928662", "R-MMU-201451", "R-BTA-1483166", "R-CEL-9013406", "R-HSA-1483115", "R-SPO-399997", "R-HSA-112399", "R-SCE-9031628", "R-MMU-114508", "R-GGA-264642", "R-CEL-8856828", "R-BTA-180292", "R-HSA-3000170", "R-HSA-5655332", "R-GGA-8856825", "R-SPO-5628897", "R-RNO-210500", "R-HSA-109704", "R-SCE-9009391", "R-HSA-5099900", "R-BTA-399997", "R-HSA-2871809", "R-MMU-1257604", "R-DDI-112043", "R-HSA-9842663", "R-DME-8939236", "R-DME-2173795", "R-DDI-9648002", "R-DDI-5675221", "R-CEL-2672351", "R-HSA-9725371", "R-HSA-8856825", "R-DDI-450385", "R-RNO-983695", "R-BTA-9027276", "R-RNO-5654227", "R-RNO-166016", "R-SCE-198693", "R-CEL-114604", "R-MMU-168138", "R-HSA-2173788", "R-RNO-416993", "R-DME-5689880", "R-MMU-1253288", "R-XTR-6811436", "R-RNO-877300", "R-MMU-1433559", "R-MMU-111995", "R-HSA-180292", "R-RNO-1483166", "R-HSA-5689896", "R-HSA-8856828", "R-HSA-166016", "R-RNO-5621480", "R-MMU-5099900", "R-BTA-202424", "R-HSA-5654228", "R-CEL-432722", "R-CFA-1660499", "R-MMU-5625740", "R-CEL-5099900", "R-SPO-202424", "R-CEL-4419969", "R-RNO-9027276", "R-MMU-2122948", "R-SPO-1660516", "R-CEL-5673001", "R-DDI-6804757", "R-MMU-389357", "R-CEL-1169091", "R-MMU-5654695", "R-XTR-5099900", "R-RNO-72165", "R-DRE-6798695", "R-CEL-5654228", "R-HSA-1855183", "R-HSA-9673767", "R-MMU-1482798", "R-DDI-9013423", "R-DRE-76005", "R-RNO-9013408", "R-DME-4608870", "R-RNO-5673001", "R-GGA-1482922", "R-DRE-5668599", "R-GGA-8856828", "R-HSA-212718", "R-HSA-9927354", "R-HSA-373753", "R-MMU-1433557", "R-DRE-1482798", "R-SPO-165158", "R-MMU-180292", "R-HSA-210993", "R-CEL-201556", "R-DRE-416993", "R-HSA-9034793", "R-CEL-180292", "R-HSA-450520", "R-HSA-5250989", "R-BTA-1482925", "R-SPO-5218920", "R-HSA-2029482", "R-HSA-4641258", "R-DDI-203615", "R-XTR-5218921", "R-HSA-5218921", "R-SPO-8980692", "R-BTA-5668599", "R-HSA-4419969", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-9013406", "R-MMU-6798695", "R-MMU-9027276", "R-CEL-186763", "R-DDI-9031628", "R-MMU-2173788", "R-DDI-1489509", "R-MMU-1660517", "R-RNO-432142", "R-MMU-114608", "R-MMU-5610780", "R-HSA-1660517", "R-BTA-210500", "R-SCE-1855204", "R-XTR-1482922", "R-GGA-1482801", "R-CFA-8948751", "R-BTA-1482788", "R-DDI-6811558", "R-SPO-1474151", "R-DDI-1660499", "R-BTA-5654720", "R-CEL-392451", "R-RNO-109704", "R-RNO-450520", "R-MMU-983231", "R-XTR-1483166", "R-HSA-1660499", "R-RNO-1660514", "R-DME-264642", "R-GGA-1855204", "R-MMU-9842663", "R-RNO-5668599", "R-BTA-186763", "R-HSA-2871837", "R-HSA-210990", "R-HSA-112126", "R-RNO-1660516", "R-HSA-5610787", "R-DME-9013406", "R-DRE-9013149", "R-DRE-2142753", "R-CEL-181429", "R-RNO-114508", "R-HSA-432722", "R-DDI-198693", "R-CFA-8948747", "R-HSA-445355", "R-HSA-2173791", "R-MMU-888590", "R-DDI-1660516", "R-RNO-76005", "R-HSA-1660514", "R-RNO-5654221", "R-HSA-5632684", "R-HSA-9824585", "R-HSA-5654227", "R-HSA-888590", "R-DRE-9013148", "R-MMU-1482922", "R-CEL-1169408", "R-RNO-5607764", "R-SPO-6804758", "R-MMU-9927354", "R-HSA-9845576", "R-CEL-4420097", "R-MMU-416482", "R-DME-114516", "R-RNO-1855204", "R-MMU-1482801", "R-HSA-9664422", "R-SCE-202424", "R-HSA-392451", "R-MMU-418885", "R-HSA-9013409", "R-SPO-2029485", "R-BTA-112043", "R-HSA-5689880", "R-RNO-1474228", "R-MMU-4086398", "R-SPO-389357", "R-MMU-9013408", "R-RNO-9009391", "R-HSA-1489509", "R-MMU-210993", "R-DDI-416476", "R-RNO-1433559", "R-MMU-210990", "R-DME-5218921", "R-BTA-1963642", "R-MMU-8854214", "R-CEL-888590", "R-RNO-111465", "R-DDI-5213460", "R-SCE-6804757", "R-HSA-8853659", "R-CFA-199418", "R-MMU-9013420", "R-SPO-5668599", "R-DDI-5218920", "R-MMU-1482788", "R-DDI-5673000", "R-HSA-2028269", "R-CEL-3000170", "R-MMU-5620912", "R-MMU-5673001", "R-HSA-210500", "R-SPO-392451", "R-RNO-212718", "R-BTA-5625740", "R-HSA-9026527", "R-BTA-181430", "R-HSA-181430", "R-SPO-9031628", "R-HSA-434316", "R-RNO-1855183", "R-RNO-210993", "R-HSA-2424491", "R-MMU-72163", "R-HSA-416482", "R-BTA-1482839", "R-HSA-5637810", "R-CEL-9648002", "R-HSA-9696264", "R-RNO-6811436", "R-MMU-1483166", "R-HSA-1445148", "R-HSA-111933", "R-MMU-193648", "R-CEL-1660517", "R-HSA-9013026", "R-MMU-2730905", "R-DDI-202433", "R-XTR-9020702", "R-HSA-9754560", "R-DME-201451", "R-CEL-8856825", "R-HSA-212676", "R-HSA-9664323", "R-RNO-8851907", "R-HSA-1839117", "R-SCE-1660516", "R-DME-983168", "R-HSA-5655253", "R-DDI-165159", "R-GGA-1482788", "R-HSA-8854214", "R-MMU-8980692", "R-CEL-1489509", "R-RNO-1169408", "R-SCE-6798695", "R-XTR-432142", "R-HSA-2029485", "R-HSA-9013106", "R-DME-114508", "R-CEL-5607764", "R-SPO-5218921", "R-GGA-1482925", "R-CEL-983168", "R-RNO-399997", "R-SCE-6804758", "R-MMU-8939236", "R-HSA-9013423", "R-MMU-1483206", "R-HSA-8851907", "R-DRE-1483115", "R-BTA-912526", "R-CEL-373752", "R-MMU-512988", "R-DME-416476", "R-SPO-9013420", "R-HSA-1250196", "R-HSA-4086398", "R-SPO-6804757", "R-SPO-198693", "R-DDI-5668599", "R-HSA-9027276", "R-MMU-202424", "R-SCE-5625740", "R-BTA-8856828", "R-HSA-381038", "R-RNO-8849471", "R-HSA-5655291", "R-DDI-1632852", "R-MMU-109704", "R-MMU-212676", "R-RNO-1250342", "R-HSA-8943723", "R-SPO-1660514", "R-MMU-1169091", "R-MMU-1660499", "R-HSA-1482801", "R-RNO-9856530", "R-SCE-392451", "R-HSA-5654219", "R-MMU-212718", "R-RNO-5654695", "R-BTA-109704", "R-CEL-5654689", "R-HSA-912526", "R-HSA-201556", "R-SPO-199418", "R-HSA-111465", "R-MMU-5654689", "R-SPO-72163", "R-HSA-8939236", "R-SCE-5218920", "R-HSA-422356", "R-MMU-9607240", "R-MMU-5607764", "R-RNO-5654710", "R-XTR-418592", "R-DDI-1483206", "R-CEL-912631", "R-SCE-450385", "R-HSA-8849471", "R-HSA-4420097", "R-SPO-9013106", "R-SCE-5607764", "R-CEL-114508", "R-CEL-1433559", "R-HSA-4641257", "R-RNO-202424", "R-MMU-5668599", "R-MMU-1660514", "R-SCE-9013420", "R-BTA-1482798", "R-RNO-9013406", "R-DDI-1660517", "R-HSA-5621480", "R-CEL-9013148", "R-HSA-5655302", "R-SCE-9856530", "R-RNO-389357", "R-RNO-201556", "R-RNO-199418", "R-HSA-9665686", "R-SPO-5607764", "R-CFA-1855204", "R-RNO-8853659", "R-MMU-166016", "R-RNO-1483115", "R-DME-9668328", "R-HSA-9755511", "R-BTA-912631", "R-DME-2173791", "R-MMU-111933", "R-MMU-6811436", "R-BTA-416476", "R-DME-399997", "R-HSA-9013149", "R-BTA-1855204", "R-RNO-1660517", "R-HSA-1169091", "R-HSA-5658442", "R-HSA-8980692", "R-SPO-389513", "R-DME-181430", "R-HSA-5654720", "R-HSA-1253288", "R-BTA-114604", "R-HSA-8948751", "R-HSA-418890", "R-MMU-199418", "R-RNO-5689896", "R-RNO-181429", "R-SPO-2179392", "R-BTA-9013106", "R-SCE-202433", "R-SPO-1489509", "R-HSA-2122948", "R-CEL-1632852", "R-HSA-416476", "R-MMU-9845576", "R-MMU-1483115", "R-DDI-9013149", "R-HSA-9032759", "R-SCE-1169091", "R-SCE-8948751", "R-HSA-1236382", "R-RNO-9845576", "R-SCE-1257604", "R-DME-8856828", "R-MMU-5625886", "R-RNO-9013106", "R-DRE-9856530", "R-DME-181429", "R-RNO-5099900", "R-SPO-1257604", "R-HSA-5620912", "R-HSA-5607764", "R-DME-1489509", "R-MMU-5654228", "R-DME-4419969", "R-RNO-8948747", "R-MMU-416993", "R-HSA-193648", "R-GGA-6811436", "R-MMU-202433", "R-SSC-1855204", "R-MMU-181429", "R-GGA-432142", "R-DME-212676", "R-CFA-5689896", "R-MMU-418592", "R-BTA-2730905", "R-RNO-5218921", "R-XTR-1482788", "R-DME-5632684", "R-RNO-5654720", "R-CEL-1660499", "R-DDI-5607764", "R-MMU-2424491", "R-DRE-1482801", "R-DDI-114508", "R-SCE-5668599", "R-HSA-8939246", "R-RNO-186763", "R-DDI-9954716", "R-HSA-9696273", "R-SCE-2871837", "R-XTR-1169091"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DDI-114604:r:GPVI-mediated activation cascade", "R-XTR-1482801:r:Acyl chain remodelling of PS", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-BTA-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-1632852:r:Macroautophagy", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SPO-165181:r:Inhibition of TSC complex formation by PKB", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-DDI-202424:r:Downstream TCR signaling", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-201556:r:Signaling by ALK", "R-HSA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-RNO-416476:r:G alpha (q) signalling events", "R-DRE-201451:r:Signaling by BMP", "R-SCE-165158:r:Activation of AKT2", "R-SCE-9696273:r:RND1 GTPase cycle", "R-DDI-399997:r:Acetylcholine regulates insulin secretion", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-112043:r:PLC beta mediated events", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-GGA-1483166:r:Synthesis of PA", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-SCE-1489509:r:DAG and IP3 signaling", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-1632852:r:Macroautophagy", "R-CEL-112043:r:PLC beta mediated events", "R-DME-112043:r:PLC beta mediated events", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DRE-8980692:r:RHOA GTPase cycle", "R-XTR-2142753:r:Arachidonate metabolism", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-1483206:r:Glycerophospholipid biosynthesis", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-202433:r:Generation of second messenger molecules", "R-MMU-2142753:r:Arachidonate metabolism", "R-HSA-201451:r:Signaling by BMP", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-111933:r:Calmodulin induced events", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-SCE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DME-2028269:r:Signaling by Hippo", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-MMU-5621480:r:Dectin-2 family", "R-RNO-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-111995:r:phospho-PLA2 pathway", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-SPO-2871837:r:FCERI mediated NF-kB activation", "R-DDI-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-SPO-202433:r:Generation of second messenger molecules", "R-CEL-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-210993:r:Tie2 Signaling", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-SPO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-MMU-432142:r:Platelet sensitization by LDL", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-2871837:r:FCERI mediated NF-kB activation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-8853659:r:RET signaling", "R-DDI-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-8948747:r:Regulation of PTEN localization", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-BTA-112399:r:IRS-mediated signalling", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-CEL-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-RNO-1482801:r:Acyl chain remodelling of PS", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-DRE-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-RNO-1482922:r:Acyl chain remodelling of PI", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DRE-1482925:r:Acyl chain remodelling of PG", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-XTR-6798695:r:Neutrophil degranulation", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DDI-5625740:r:RHO GTPases activate PKNs", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-DME-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-SPO-1632852:r:Macroautophagy", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-114516:r:Disinhibition of SNARE formation", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9648002:r:RAS processing", "R-DDI-8948747:r:Regulation of PTEN localization", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DDI-2871837:r:FCERI mediated NF-kB activation", "R-CEL-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-CEL-416476:r:G alpha (q) signalling events", "R-XTR-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-6794361:r:Neurexins and neuroligins", "R-CFA-5689880:r:Ub-specific processing proteases", "R-MMU-198203:r:PI3K/AKT activation", "R-DDI-76005:r:Response to elevated platelet cytosolic Ca2+", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-RNO-114608:r:Platelet degranulation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-BTA-201556:r:Signaling by ALK", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-DDI-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-CEL-202433:r:Generation of second messenger molecules", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-3295583:r:TRP channels", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-BTA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-RNO-2142753:r:Arachidonate metabolism", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-XTR-111995:r:phospho-PLA2 pathway", "R-HSA-2142753:r:Arachidonate metabolism", "R-DRE-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-1482922:r:Acyl chain remodelling of PI", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-186763:r:Downstream signal transduction", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-111995:r:phospho-PLA2 pathway", "R-DME-3000170:r:Syndecan interactions", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-114508:r:Effects of PIP2 hydrolysis", "R-BTA-9020702:r:Interleukin-1 signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "R-HSA-202424:r:Downstream TCR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-XTR-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SCE-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9607240:r:FLT3 Signaling", "R-DDI-5689896:r:Ovarian tumor domain proteases", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-RNO-111995:r:phospho-PLA2 pathway", "R-CEL-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-RNO-9607240:r:FLT3 Signaling", "R-RNO-202433:r:Generation of second messenger molecules", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-3000170:r:Syndecan interactions", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-DME-9013148:r:CDC42 GTPase cycle", "R-RNO-1632852:r:Macroautophagy", "R-XTR-114516:r:Disinhibition of SNARE formation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210990:r:PECAM1 interactions", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-DME-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-1489509:r:DAG and IP3 signaling", "R-SPO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-GGA-1483115:r:Hydrolysis of LPC", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-RNO-112043:r:PLC beta mediated events", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-DRE-1483166:r:Synthesis of PA", "R-HSA-1433559:r:Regulation of KIT signaling", "R-CEL-418597:r:G alpha (z) signalling events", "R-HSA-418597:r:G alpha (z) signalling events", "R-BTA-2142753:r:Arachidonate metabolism", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-9648002:r:RAS processing", "R-BTA-2424491:r:DAP12 signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-1482788:r:Acyl chain remodelling of PC", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-9842663:r:Signaling by LTK", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9035034:r:RHOF GTPase cycle", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-GGA-1482798:r:Acyl chain remodeling of CL", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-HSA-1483166:r:Synthesis of PA", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-GGA-111995:r:phospho-PLA2 pathway", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-CEL-111933:r:Calmodulin induced events", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-RNO-1482925:r:Acyl chain remodelling of PG", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-GGA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DRE-114516:r:Disinhibition of SNARE formation", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-912631:r:Regulation of signaling by CBL", "R-SPO-114508:r:Effects of PIP2 hydrolysis", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SPO-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-SCE-9013106:r:RHOC GTPase cycle", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-BTA-9607240:r:FLT3 Signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-CEL-1250342:r:PI3K events in ERBB4 signaling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-XTR-1482925:r:Acyl chain remodelling of PG", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DDI-2028269:r:Signaling by Hippo", "R-DME-9013420:r:RHOU GTPase cycle", "R-RNO-1482798:r:Acyl chain remodeling of CL", "R-GGA-1482839:r:Acyl chain remodelling of PE", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-432142:r:Platelet sensitization by LDL", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-9035034:r:RHOF GTPase cycle", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-RNO-112399:r:IRS-mediated signalling", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-164944:r:Nef and signal transduction", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DRE-9013106:r:RHOC GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DRE-432142:r:Platelet sensitization by LDL", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-432142:r:Platelet sensitization by LDL", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8853659:r:RET signaling", "R-CEL-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-DRE-1482788:r:Acyl chain remodelling of PC", "R-CEL-202424:r:Downstream TCR signaling", "R-BTA-111995:r:phospho-PLA2 pathway", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-5250958:r:Toxicity of botulinum toxin type B (botB)", "R-SCE-203615:r:eNOS activation", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-SPO-8948751:r:Regulation of PTEN stability and activity", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2028269:r:Signaling by Hippo", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-111933:r:Calmodulin induced events", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DDI-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-114516:r:Disinhibition of SNARE formation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SCE-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-HSA-112043:r:PLC beta mediated events", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DRE-1482839:r:Acyl chain remodelling of PE", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SPO-114604:r:GPVI-mediated activation cascade", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-373752:r:Netrin-1 signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-9648002:r:RAS processing", "R-CFA-202424:r:Downstream TCR signaling", "R-XTR-1482839:r:Acyl chain remodelling of PE", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-8948747:r:Regulation of PTEN localization", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-877300:r:Interferon gamma signaling", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-112399:r:IRS-mediated signalling", "R-SPO-203615:r:eNOS activation", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-BTA-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-2142753:r:Arachidonate metabolism", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DDI-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-BTA-1483115:r:Hydrolysis of LPC", "R-BTA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-BTA-198203:r:PI3K/AKT activation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-GGA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-912631:r:Regulation of signaling by CBL", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-912631:r:Regulation of signaling by CBL", "R-SCE-198323:r:AKT phosphorylates targets in the cytosol", "R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-XTR-1483115:r:Hydrolysis of LPC", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-DME-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DDI-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-8948747:r:Regulation of PTEN localization", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-SCE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-XTR-1482798:r:Acyl chain remodeling of CL", "R-MMU-4641258:r:Degradation of DVL", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-5674404:r:PTEN Loss of Function in Cancer", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-SCE-114604:r:GPVI-mediated activation cascade", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-DRE-4641257:r:Degradation of AXIN", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-RNO-1489509:r:DAG and IP3 signaling", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-201451:r:Signaling by BMP", "R-BTA-1483166:r:Synthesis of PA", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-1483115:r:Hydrolysis of LPC", "R-SPO-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-112399:r:IRS-mediated signalling", "R-SCE-9031628:r:NGF-stimulated transcription", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-GGA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-180292:r:GAB1 signalosome", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-109704:r:PI3K Cascade", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DDI-112043:r:PLC beta mediated events", "R-HSA-9842663:r:Signaling by LTK", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DDI-9648002:r:RAS processing", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-SCE-198693:r:AKT phosphorylates targets in the nucleus", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-XTR-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-877300:r:Interferon gamma signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-MMU-111995:r:phospho-PLA2 pathway", "R-HSA-180292:r:GAB1 signalosome", "R-RNO-1483166:r:Synthesis of PA", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-5621480:r:Dectin-2 family", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-202424:r:Downstream TCR signaling", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-DRE-6798695:r:Neutrophil degranulation", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DRE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-GGA-1482922:r:Acyl chain remodelling of PI", "R-DRE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-373753:r:Nephrin family interactions", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-DRE-1482798:r:Acyl chain remodeling of CL", "R-SPO-165158:r:Activation of AKT2", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-CEL-201556:r:Signaling by ALK", "R-DRE-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-CEL-180292:r:GAB1 signalosome", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-5250989:r:Toxicity of botulinum toxin type G (botG)", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-4641258:r:Degradation of DVL", "R-DDI-203615:r:eNOS activation", "R-XTR-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-186763:r:Downstream signal transduction", "R-DDI-9031628:r:NGF-stimulated transcription", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DDI-1489509:r:DAG and IP3 signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-432142:r:Platelet sensitization by LDL", "R-MMU-114608:r:Platelet degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-XTR-1482922:r:Acyl chain remodelling of PI", "R-GGA-1482801:r:Acyl chain remodelling of PS", "R-CFA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-109704:r:PI3K Cascade", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-GGA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-9842663:r:Signaling by LTK", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-186763:r:Downstream signal transduction", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DRE-2142753:r:Arachidonate metabolism", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-198693:r:AKT phosphorylates targets in the nucleus", "R-CFA-8948747:r:Regulation of PTEN localization", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-HSA-9845576:r:Glycosphingolipid transport", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-DME-114516:r:Disinhibition of SNARE formation", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SCE-202424:r:Downstream TCR signaling", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-112043:r:PLC beta mediated events", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-4086398:r:Ca2+ pathway", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-210993:r:Tie2 Signaling", "R-DDI-416476:r:G alpha (q) signalling events", "R-RNO-1433559:r:Regulation of KIT signaling", "R-MMU-210990:r:PECAM1 interactions", 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"R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-3371568:r:Attenuation phase", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Homologous_superfamily"}, "IPR035899": {"description": "Dbl homology (DH) domain superfamily", "go_ids": [], "go_terms": [], "name": "DBL_dom_sf", "pathway_ids": ["R-RNO-9013026", "R-MMU-8856828", "R-SPO-416482", "R-MMU-180336", "R-RNO-9013409", "R-MMU-6811558", "R-GGA-446388", "R-HSA-2871796", "R-HSA-912631", "R-MMU-3928665", "R-RNO-446388", "R-HSA-9027284", "R-RNO-512988", "R-MMU-8948751", "R-RNO-2871809", "R-RNO-5218920", "R-RNO-912631", "R-GGA-416482", "R-BTA-4420097", "R-CEL-9607240", "R-BTA-6811558", "R-HSA-512988", "R-RNO-416476", "R-RNO-193648", "R-MMU-186763", "R-MMU-9035034", "R-DME-9607240", "R-CFA-9013148", "R-HSA-983695", "R-MMU-399955", "R-DDI-5673001", "R-RNO-9013148", "R-CEL-74751", "R-SCE-193648", "R-DME-5218920", "R-MMU-912526", "R-HSA-5654700", "R-HSA-9748787", "R-CEL-1433557", "R-CEL-8851805", "R-DME-193648", "R-MMU-179812", "R-DRE-8980692", "R-BTA-8980692", "R-MMU-977443", "R-MMU-5654712", "R-MMU-9696264", "R-RNO-9013420", "R-HSA-179812", "R-DDI-9013418", "R-HSA-9680350", "R-RNO-2871796", 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"R-HSA-5654693", "R-DRE-5673001", "R-MMU-416572", "R-CEL-5673001", "R-BTA-389359", "R-DME-210993", "R-CEL-5654700", "R-HSA-399955", "R-DME-3928665", "R-HSA-9673767", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-9013408", "R-MMU-74751", "R-DDI-9013423", "R-RNO-5673001", "R-RNO-9748787", "R-MMU-2428933", "R-DME-5654704", "R-MMU-1433557", "R-GGA-9013148", "R-HSA-210993", "R-HSA-3928664", "R-DME-3928662", "R-RNO-3928663", "R-HSA-2029482", "R-HSA-8876198", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-DME-2871796", "R-DME-8853659", "R-MMU-8876198", "R-MMU-9013406", "R-CEL-1963640", "R-CEL-186763", "R-HSA-1257604", "R-DRE-9013423", "R-MMU-2179392", "R-HSA-167044", "R-DME-5654700", "R-HSA-74751", "R-RNO-8876198", "R-DME-5654693", "R-MMU-9013148", "R-HSA-375165", "R-HSA-1250347", "R-DME-2428933", "R-RNO-2029482", "R-MMU-9842663", "R-CEL-5654706", "R-HSA-9673770", "R-HSA-9035034", "R-DRE-9013149", "R-CEL-5654699", "R-DME-9748787", "R-DME-1250347", "R-HSA-8851805", "R-RNO-8856825", "R-HSA-2173791", "R-MMU-5218920", "R-HSA-5654706", "R-CEL-445144", "R-DME-983695", "R-MMU-2029482", "R-HSA-186763", "R-DRE-9013148", "R-HSA-3928663", "R-CEL-4420097", "R-HSA-112412", "R-MMU-416482", "R-MMU-3928662", "R-HSA-9013406", "R-RNO-182971", "R-DME-179812", "R-HSA-9664422", "R-CFA-416482", "R-DME-9013423", "R-CEL-5218920", "R-MMU-418885", "R-DDI-1169092", "R-HSA-9013409", "R-HSA-9607240", "R-MMU-114604", "R-MMU-9013408", "R-RNO-5687128", "R-MMU-9013409", "R-MMU-210993", "R-HSA-442982", "R-DME-9013148", "R-HSA-5218920", "R-MMU-5654706", "R-RNO-6811558", "R-HSA-8853659", "R-MMU-8851805", "R-HSA-389359", "R-DME-74751", "R-MMU-9013420", "R-MMU-5673001", "R-HSA-114604", "R-DME-1433559", "R-GGA-9013420", "R-MMU-167044", "R-DME-9013149", "R-HSA-182971", "R-CFA-8980692", "R-HSA-2424491", "R-HSA-416482", "R-SPO-9013148", "R-HSA-8983432", "R-HSA-5637810", "R-HSA-9696264", "R-MMU-9013423", "R-HSA-5654699", "R-HSA-1433559", "R-DME-1257604", "R-DME-416482", "R-MMU-193648", "R-RNO-9696264", "R-HSA-9013026", "R-HSA-445144", "R-MMU-2730905", "R-MMU-5687128", "R-CEL-8849932", "R-HSA-1839117", "R-BTA-2029482", "R-HSA-5655253", "R-HSA-416572", "R-DME-5673001", "R-RNO-9035034", "R-MMU-8980692", "R-MMU-5654699", "R-HSA-9013106", "R-HSA-9665348", "R-HSA-2428933", "R-BTA-9013148", "R-RNO-9027284", "R-DME-1433557", "R-BTA-9013423", "R-HSA-9013423", "R-MMU-1250347", "R-MMU-512988", "R-HSA-1250196", "R-HSA-2730905", "R-CFA-416572", "R-GGA-193648", "R-HSA-5654719", "R-MMU-112412", "R-HSA-9032845", "R-DME-5654699", "R-MMU-9027284", "R-BTA-1433557", "R-BTA-512988", "R-CEL-193648", "R-CEL-9013423", "R-MMU-3928664", "R-HSA-1963640", "R-HSA-5655291", "R-MMU-912631", "R-DRE-9013409", "R-HSA-5654712", "R-MMU-9028731", "R-DME-112412", "R-DME-167044", "R-DDI-392517", "R-MMU-8983432", "R-CEL-3928665", "R-HSA-9634285", "R-BTA-9013404", "R-HSA-912526", "R-BTA-1257604", "R-MMU-5654693", "R-HSA-446388", "R-BTA-9027284", "R-MMU-9013149", "R-DME-5654706", "R-MMU-74749", "R-HSA-5654688", "R-HSA-1989781", "R-DDI-354192", "R-MMU-182971", "R-MMU-389359", "R-MMU-9607240", "R-DME-375165", "R-CEL-354194", "R-DME-114604", "R-CEL-912631", "R-RNO-9013149", "R-HSA-2179392", "R-MMU-9013404", "R-HSA-9013424", "R-CEL-416482", "R-MMU-446388", "R-HSA-3928662", "R-HSA-4420097", "R-MMU-2871796", "R-DME-2424491", "R-RNO-9013424", "R-BTA-2871809", "R-CEL-1433559", "R-RNO-9013406", "R-HSA-9664565", "R-HSA-5655302", "R-CEL-9013148", "R-CEL-5654693", "R-DDI-193648", "R-MMU-9748787", "R-HSA-9665686", "R-DME-8980692", "R-MMU-8853659", "R-HSA-2219530", "R-MMU-445144", "R-DME-5654688", "R-BTA-912631", "R-MMU-5654700", "R-RNO-8964616", "R-RNO-9696273", "R-RNO-418885", "R-HSA-9013404", "R-SCE-9013148", "R-HSA-9013149", "R-HSA-8980692", "R-DME-445144", "R-CFA-9013106", "R-HSA-9703648", "R-DME-1963640", "R-BTA-114604", "R-HSA-8948751", "R-MMU-5654688", "R-DRE-416482", "R-HSA-5654704", "R-BTA-9013106", "R-RNO-4420097", "R-MMU-375165", "R-RNO-977443", "R-CEL-375165", "R-MMU-8856825", "R-HSA-977443", "R-HSA-416476", "R-HSA-418885", "R-DDI-9013149", "R-CEL-9013149", "R-DME-6811558", "R-DDI-381676", "R-DME-2871809", "R-HSA-1236382", "R-BTA-2871796", "R-HSA-9619229", "R-RNO-9013106", "R-MMU-5654719", "R-HSA-9028731", "R-HSA-193648", "R-HSA-9013420", "R-DRE-9013408", "R-DDI-171007", "R-HSA-8964616", "R-HSA-354194", "R-MMU-3928663", "R-HSA-9679191", "R-MMU-983695", "R-HSA-1433557", "R-CEL-180336", "R-RNO-114604", "R-HSA-9703465", "R-BTA-9013408", "R-GGA-8964616", "R-HSA-5687128", "R-MMU-2871809", "R-MMU-9013026", "R-MMU-2424491", "R-DRE-416476", "R-DME-4420097", "R-CFA-193648", "R-HSA-9696273", "R-CEL-5654704"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-GGA-416482:r:G alpha (12/13) signalling events", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-9607240:r:FLT3 Signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9607240:r:FLT3 Signaling", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-SCE-193648:r:NRAGE signals death through JNK", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-8851805:r:MET activates RAS signaling", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DRE-8980692:r:RHOA GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-977443:r:GABA receptor activation", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-CEL-9748787:r:Azathioprine ADME", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-HSA-74749:r:Signal attenuation", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-3928664:r:Ephrin signaling", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DME-74749:r:Signal attenuation", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-428540:r:Activation of RAC1", "R-DME-186763:r:Downstream signal transduction", "R-DRE-193648:r:NRAGE signals death through JNK", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-210993:r:Tie2 Signaling", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-912631:r:Regulation of signaling by CBL", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-DME-210993:r:Tie2 Signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-9748787:r:Azathioprine ADME", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-3928664:r:Ephrin signaling", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-DME-8853659:r:RET signaling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-186763:r:Downstream signal transduction", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9842663:r:Signaling by LTK", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-9748787:r:Azathioprine ADME", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8851805:r:MET activates RAS signaling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-445144:r:Signal transduction by L1", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-186763:r:Downstream signal transduction", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-182971:r:EGFR downregulation", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-DME-9013423:r:RAC3 GTPase cycle", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-418885:r:DCC mediated attractive signaling", "R-DDI-1169092:r:Activation of RAS in B cells", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9607240:r:FLT3 Signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-DME-74751:r:Insulin receptor signalling cascade", "R-MMU-9013420:r:RHOU GTPase cycle", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-GGA-9013420:r:RHOU GTPase cycle", "R-MMU-167044:r:Signalling to RAS", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-CFA-8980692:r:RHOA GTPase cycle", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-HSA-8983432:r:Interleukin-15 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1433559:r:Regulation of KIT signaling", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-DME-1433557:r:Signaling by SCF-KIT", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-GGA-193648:r:NRAGE signals death through JNK", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-112412:r:SOS-mediated signalling", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-193648:r:NRAGE signals death through JNK", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-912631:r:Regulation of signaling by CBL", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DME-112412:r:SOS-mediated signalling", "R-DME-167044:r:Signalling to RAS", "R-DDI-392517:r:Rap1 signalling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-74749:r:Signal attenuation", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-354192:r:Integrin signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-114604:r:GPVI-mediated activation cascade", "R-CEL-912631:r:Regulation of signaling by CBL", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DME-2424491:r:DAP12 signaling", "R-RNO-9013424:r:RHOV GTPase cycle", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-1433559:r:Regulation of KIT signaling", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-9748787:r:Azathioprine ADME", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-8853659:r:RET signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-BTA-912631:r:Regulation of signaling by CBL", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-CFA-9013106:r:RHOC GTPase cycle", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-RNO-977443:r:GABA receptor activation", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-977443:r:GABA receptor activation", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DRE-9013408:r:RHOG GTPase cycle", "R-DDI-171007:r:p38MAPK events", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-9013408:r:RHOG GTPase cycle", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-2424491:r:DAP12 signaling", "R-DRE-416476:r:G alpha (q) signalling events", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-CFA-193648:r:NRAGE signals death through JNK", "R-HSA-9696273:r:RND1 GTPase cycle", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3"], "type": "Homologous_superfamily"}, "IPR035900": {"description": "Colicin E immunity protein superfamily", "go_ids": [], "go_terms": [], "name": "Colicin_E_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035901": {"description": "GIY-YIG endonuclease superfamily", "go_ids": [], "go_terms": [], "name": "GIY-YIG_endonuc_sf", "pathway_ids": ["R-MMU-5693568", "R-BTA-5693568", "R-HSA-5693568", "R-HSA-6783310", "R-BTA-6783310", "R-RNO-6783310", "R-RNO-5693568", "R-MMU-6783310"], "pathways": ["R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Homologous_superfamily"}, "IPR035902": {"description": "Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily", "go_ids": [], "go_terms": [], "name": "Nuc_phospho_transferase", "pathway_ids": ["R-RNO-73621", "R-MMU-73614", "R-HSA-73621", "R-HSA-73614", "R-MMU-73621", "R-RNO-73614"], "pathways": ["R-RNO-73621:r:Pyrimidine catabolism", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-73614:r:Pyrimidine salvage"], "type": "Homologous_superfamily"}, "IPR035903": {"description": "HesB-like domain superfamily", "go_ids": [], "go_terms": [], "name": "HesB-like_dom_sf", "pathway_ids": ["R-RNO-9854311", "R-HSA-1362409", "R-HSA-9854311", "R-BTA-9854311", "R-SCE-1362409", "R-RNO-1362409", "R-MMU-9854311", "R-MMU-1362409", "R-BTA-1362409", "R-DDI-1362409", "R-SPO-1362409", "R-DME-1362409"], "pathways": ["R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-BTA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DDI-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DME-1362409:r:Mitochondrial iron-sulfur cluster biogenesis"], "type": "Homologous_superfamily"}, "IPR035904": {"description": "Chorismate synthase AroC superfamily", "go_ids": [], "go_terms": [], "name": "Chorismate_synth_AroC_sf", "pathway_ids": ["PWY-6163", "R-MTU-964903"], "pathways": ["PWY-6163:t:chorismate biosynthesis from 3-dehydroquinate", "R-MTU-964903:r:Chorismate via Shikimate Pathway"], "type": "Homologous_superfamily"}, "IPR035905": {"description": "Barstar-like superfamily", "go_ids": [], "go_terms": [], "name": "Barstar-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035906": {"description": "MetI-like superfamily", "go_ids": [], "go_terms": [], "name": "MetI-like_sf", "pathway_ids": ["R-HSA-9927020", "R-HSA-1222538"], "pathways": ["R-HSA-9927020:r:Heme assimilation", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Homologous_superfamily"}, "IPR035907": {"description": "7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily", "go_ids": [], "go_terms": [], "name": "Hppk_sf", "pathway_ids": ["PWY-7853", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7852", "PWY-6148"], "pathways": ["PWY-7853:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis V (Pyrococcus)", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7852:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)", "PWY-6148:t:tetrahydromethanopterin biosynthesis"], "type": "Homologous_superfamily"}, "IPR035908": {"description": "ATP synthase, F0 complex, subunit A superfamily", "go_ids": [], "go_terms": [], "name": "F0_ATP_A_sf", "pathway_ids": ["R-MMU-9837999", "R-HSA-5419276", "R-CEL-163210", "R-DME-8949613", "R-GGA-5419276", "R-RNO-5419276", "R-BTA-8949613", "R-BTA-9837999", "R-HSA-9837999", "R-RNO-163210", "R-DRE-8949613", "R-GGA-163210", "R-MMU-8949613", "R-GGA-8949613", "R-DRE-5419276", "R-SSC-163210", "R-DDI-9837999", "R-CEL-9837999", "R-SSC-8949613", "R-SSC-5419276", "R-DME-9837999", "R-MMU-163210", "R-DME-163210", "R-CEL-8949613", "R-RNO-9837999", "R-HSA-8949613", "R-HSA-163210", "R-DRE-9837999", "R-SPO-9837999", "R-SCE-9837999", "R-GGA-9837999", "R-MMU-5419276", "R-DME-5419276", "R-BTA-163210", "R-BTA-5419276", "R-CEL-5419276", "R-SSC-9837999", "R-RNO-8949613", "R-DRE-163210"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-8949613:r:Cristae formation", "R-GGA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-BTA-8949613:r:Cristae formation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-DRE-8949613:r:Cristae formation", "R-GGA-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-8949613:r:Cristae formation", "R-GGA-8949613:r:Cristae formation", "R-DRE-5419276:r:Mitochondrial translation termination", "R-SSC-163210:r:Formation of ATP by chemiosmotic coupling", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SSC-8949613:r:Cristae formation", "R-SSC-5419276:r:Mitochondrial translation termination", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-GGA-9837999:r:Mitochondrial protein degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-RNO-8949613:r:Cristae formation", "R-DRE-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Homologous_superfamily"}, "IPR035909": {"description": "Methylesterase CheB, C-terminal", "go_ids": [], "go_terms": [], "name": "CheB_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035910": {"description": "RyR/IP3 receptor binding core, RIH domain superfamily", "go_ids": [], "go_terms": [], "name": "RyR/IP3R_RIH_dom_sf", "pathway_ids": ["R-MMU-139853", "R-HSA-139853", "R-CEL-983695", "R-HSA-5607763", "R-DDI-139853", "R-HSA-2672351", "R-HSA-1489509", "R-HSA-2029485", "R-DDI-5578775", "R-DME-114508", "R-MMU-418457", "R-MMU-381676", "R-RNO-2672351", "R-HSA-418457", "R-HSA-112043", "R-HSA-114508", "R-MMU-9717207", "R-MMU-2672351", "R-DDI-381676", "R-CEL-114508", "R-CEL-9717207", "R-RNO-139853", "R-DME-139853", "R-RNO-418457", "R-HSA-5578775", "R-HSA-4086398", "R-RNO-114508", "R-DME-381676", "R-MMU-114508", "R-HSA-983695", "R-RNO-9717207", "R-DME-5578775", "R-DDI-9717207", "R-RNO-5578775", "R-CEL-139853", "R-HSA-2871809", "R-MMU-5578775", "R-DME-983695", "R-DME-9717207", "R-MMU-983695", "R-RNO-381676", "R-CEL-381676", "R-HSA-5218921", "R-HSA-9717207", "R-CEL-5578775", "R-HSA-381676", "R-RNO-983695", "R-DDI-114508", "R-HSA-9664323", "R-HSA-422356"], "pathways": ["R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-CEL-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DDI-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-1489509:r:DAG and IP3 signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-5578775:r:Ion homeostasis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-MMU-418457:r:cGMP effects", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-418457:r:cGMP effects", "R-HSA-112043:r:PLC beta mediated events", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-MMU-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-CEL-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-DME-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-418457:r:cGMP effects", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-4086398:r:Ca2+ pathway", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-DME-5578775:r:Ion homeostasis", "R-DDI-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-5578775:r:Ion homeostasis", "R-CEL-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5578775:r:Ion homeostasis", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-5578775:r:Ion homeostasis", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Homologous_superfamily"}, "IPR035911": {"description": "MurE/MurF, N-terminal", "go_ids": [], "go_terms": [], "name": "MurE/MurF_N", "pathway_ids": ["PWY-7953", "PWY-6387"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)"], "type": "Homologous_superfamily"}, "IPR035912": {"description": "Enhancer of rudimentary superfamily", "go_ids": [], "go_terms": [], "name": "EHR_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035913": {"description": "RPB5-like RNA polymerase subunit superfamily", "go_ids": [], "go_terms": [], "name": "RPB5-like_sf", "pathway_ids": ["R-RNO-6781823", "R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-CEL-72165", "R-MMU-9770562", "R-RNO-73779", "R-HSA-73980", "R-HSA-427413", "R-CEL-72203", "R-DDI-73776", "R-RNO-72163", "R-DDI-6782210", "R-SPO-6781823", "R-DDI-72163", "R-RNO-9018519", "R-HSA-167158", "R-MMU-75955", "R-RNO-73776", "R-MMU-112382", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DDI-674695", "R-CEL-9770562", "R-HSA-76061", "R-MMU-76061", "R-CEL-75953", "R-SPO-6796648", "R-HSA-749476", "R-CEL-73776", "R-SCE-76061", "R-SPO-9018519", "R-SPO-76066", "R-MMU-72163", "R-HSA-6803529", "R-HSA-167242", "R-CEL-6782210", "R-HSA-8851708", "R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-RNO-76061", "R-CEL-112382", "R-HSA-9670095", "R-HSA-167160", "R-DDI-77075", "R-CEL-6782135", "R-SPO-73779", "R-DDI-113418", "R-MMU-73772", "R-MMU-72086", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-CEL-73772", "R-MMU-6781823", "R-HSA-203927", "R-DDI-73772", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-HSA-73780", "R-DDI-76042", "R-MMU-73776", "R-CEL-72163", "R-HSA-167172", "R-SCE-73779", "R-RNO-113418", "R-HSA-76071", "R-HSA-72203", "R-MMU-6796648", "R-RNO-76071", "R-HSA-9770562", "R-CEL-75955", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-SCE-6781823", "R-MMU-76071", "R-RNO-76066", "R-SCE-9018519", "R-HSA-73863", "R-RNO-77075", "R-HSA-167290", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-CEL-9018519", "R-RNO-9770562", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-RNO-6807505", "R-MMU-72203", "R-RNO-674695", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-SPO-6807505", "R-RNO-73863", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-RNO-72165", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-HSA-5601884", "R-RNO-6782210", "R-SPO-73762", "R-SPO-75953", "R-SPO-113418", "R-MMU-5250924", "R-CEL-6807505", "R-DDI-73779", "R-RNO-72203", "R-RNO-76042", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-CEL-113418", "R-RNO-73762", "R-MMU-674695", "R-MMU-6807505", "R-RNO-5578749", "R-SCE-76042", "R-DDI-6807505", "R-MMU-9018519", "R-SPO-9770562", "R-CEL-6781823", "R-HSA-167200", "R-SCE-73762", "R-RNO-112382", "R-SCE-674695", "R-MMU-6782210", "R-CEL-6796648", "R-RNO-75953", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-SCE-76066", "R-MMU-73762", "R-MMU-6782135", "R-HSA-76066", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-DDI-76061", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-SCE-6782210", "R-HSA-9918481", "R-RNO-6803529", "R-SCE-72203", "R-SCE-6796648", "R-SPO-72203", "R-RNO-72086", "R-SPO-77075", "R-RNO-73772", "R-RNO-6782135", "R-SCE-113418", "R-SCE-72086", "R-MMU-73863", "R-RNO-5250924", "R-HSA-6782135", "R-HSA-73762", "R-CEL-77075", "R-SCE-77075", "R-HSA-5250924", "R-DDI-75953", "R-SPO-6782135", "R-CEL-73762", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-6782135:r:Dual incision in TC-NER", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-9770562:r:mRNA Polyadenylation", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-SPO-9770562:r:mRNA Polyadenylation", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Homologous_superfamily"}, "IPR035914": {"description": "Spermadhesin, CUB domain superfamily", "go_ids": [], "go_terms": [], "name": "Sperma_CUB_dom_sf", "pathway_ids": ["R-HSA-186797", "R-HSA-6798695", "R-HSA-373080", "R-HSA-2243919", "R-HSA-173623", "R-DRE-399954", "R-HSA-9920588", "R-RNO-2243919", "R-CEL-6798695", "R-DRE-194306", "R-RNO-3772470", "R-HSA-2855086", "R-HSA-1650814", "R-MMU-166662", "R-MMU-2243919", "R-MMU-2214320", "R-RNO-977606", "R-MMU-975634", "R-RNO-399954", "R-DME-2214320", "R-RNO-173623", "R-MMU-399954", "R-HSA-399955", "R-HSA-3359462", "R-DRE-1650814", "R-HSA-166663", "R-HSA-447038", "R-MMU-1474228", "R-HSA-1474228", "R-DRE-9619665", "R-DME-1650814", "R-RNO-445144", "R-CEL-2214320", "R-MMU-399955", "R-HSA-9845619", "R-HSA-9694614", "R-MMU-445144", "R-RNO-8964011", "R-DRE-5362798", "R-HSA-194306", "R-HSA-447041", "R-HSA-75892", "R-RNO-196791", "R-RNO-2855086", "R-HSA-5683826", "R-HSA-399954", "R-DRE-399956", "R-MMU-5173214", "R-MMU-6798695", "R-HSA-445144", "R-RNO-373080", "R-HSA-9758881", "R-MMU-186797", "R-CEL-1650814", "R-MMU-399956", "R-MMU-194306", "R-RNO-194306", "R-HSA-8964011", "R-HSA-399956", "R-HSA-201681", "R-MMU-3772470", "R-HSA-9705671", "R-HSA-6809371", "R-HSA-3000480", "R-DRE-2243919", "R-RNO-166662", "R-MMU-2855086", "R-HSA-9619665", "R-MMU-3000480", "R-MMU-373080", "R-HSA-9845621", "R-MMU-173623", "R-GGA-186797", "R-HSA-196791", "R-CEL-1474228", "R-HSA-5362798", "R-RNO-9758881", "R-HSA-977606", "R-HSA-3359463", "R-MMU-5683826", "R-HSA-1442490", "R-HSA-3772470", "R-RNO-1650814", "R-HSA-2214320", "R-HSA-8963896", "R-MMU-977606", "R-RNO-399956", "R-HSA-5083635", "R-HSA-5339717", "R-HSA-376176", "R-RNO-186797", "R-RNO-5683826", "R-DME-2243919", "R-DME-1474228", "R-MMU-8963896", "R-HSA-5173214", "R-MMU-1650814", "R-MMU-5362798", "R-RNO-399955", "R-HSA-166662", "R-MMU-9619665", "R-MMU-1442490", "R-HSA-975634"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-2243919:r:Crosslinking of collagen fibrils", "R-CEL-6798695:r:Neutrophil degranulation", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-166662:r:Lectin pathway of complement activation", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-MMU-2214320:r:Anchoring fibril formation", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-975634:r:Retinoid metabolism and transport", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-2214320:r:Anchoring fibril formation", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-3359462:r:Defective AMN causes MGA1", "R-DRE-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-447038:r:NrCAM interactions", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DRE-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-445144:r:Signal transduction by L1", "R-CEL-2214320:r:Anchoring fibril formation", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-9694614:r:Attachment and Entry", "R-MMU-445144:r:Signal transduction by L1", "R-RNO-8964011:r:HDL clearance", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-447041:r:CHL1 interactions", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-445144:r:Signal transduction by L1", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-MMU-186797:r:Signaling by PDGF", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-8964011:r:HDL clearance", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-DRE-2243919:r:Crosslinking of collagen fibrils", "R-RNO-166662:r:Lectin pathway of complement activation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-GGA-186797:r:Signaling by PDGF", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-3359463:r:Defective CUBN causes MGA1", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-1442490:r:Collagen degradation", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-HSA-376176:r:Signaling by ROBO receptors", "R-RNO-186797:r:Signaling by PDGF", "R-RNO-5683826:r:Surfactant metabolism", "R-DME-2243919:r:Crosslinking of collagen fibrils", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-8963896:r:HDL assembly", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-166662:r:Lectin pathway of complement activation", "R-MMU-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-1442490:r:Collagen degradation", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Homologous_superfamily"}, "IPR035915": {"description": "Plakin repeat superfamily", "go_ids": [], "go_terms": [], "name": "Plakin_repeat_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-6809371", "R-DRE-9696273", "R-HSA-8851680", "R-RNO-351906", "R-HSA-9013424", "R-HSA-351906", "R-DRE-9696264", "R-MMU-9013420", "R-DRE-6798695", "R-RNO-6805567", "R-HSA-446107", "R-HSA-6805567", "R-RNO-6809371", "R-HSA-9013420", "R-RNO-446107", "R-MMU-446107", "R-HSA-9696270", "R-DRE-6805567", "R-DRE-6809371", "R-MMU-9013424", "R-MMU-351906", "R-RNO-9696273", "R-HSA-9696264", "R-MMU-8851680", "R-MMU-6809371", "R-HSA-2022090", "R-MMU-264870", "R-RNO-9696264", "R-DRE-351906", "R-MMU-6798695", "R-RNO-264870", "R-MMU-9696264", "R-HSA-264870", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-6805567", "R-RNO-6798695", "R-HSA-9696273"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-DRE-9696273:r:RND1 GTPase cycle", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-9696264:r:RND3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6805567:r:Keratinization", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6805567:r:Keratinization", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-6805567:r:Keratinization", "R-DRE-6809371:r:Formation of the cornified envelope", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-6805567:r:Keratinization", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR035916": {"description": "Egg-lysin superfamily", "go_ids": [], "go_terms": [], "name": "Egg_lysin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035917": {"description": "YjbQ-like superfamily", "go_ids": [], "go_terms": [], "name": "YjbQ-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035918": {"description": "Delta-endotoxin CytB-like superfamily", "go_ids": [], "go_terms": [], "name": "CytB_endotoxin-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035919": {"description": "EAL domain superfamily", "go_ids": [], "go_terms": [], "name": "EAL_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035920": {"description": "YhbY-like superfamily", "go_ids": [], "go_terms": [], "name": "YhbY-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035921": {"description": "F/V-ATP synthase subunit C superfamily", "go_ids": [], "go_terms": [], "name": "F/V-ATP_Csub_sf", "pathway_ids": 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"R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-CEL-983712", "R-CEL-917977", "R-MMU-983712", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-RNO-983712:r:Ion channel transport", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-BTA-8949613:r:Cristae formation", "R-MMU-1268020:r:Mitochondrial protein import", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-917977:r:Transferrin endocytosis 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"R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-CEL-8949613:r:Cristae formation", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-CEL-983712:r:Ion channel transport", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR035922": {"description": "3H domain superfamily", "go_ids": [], "go_terms": [], "name": "3H_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035923": {"description": "TT1751-like domain superfamily", "go_ids": [], "go_terms": [], "name": "TT1751-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035924": {"description": "FlaG-like superfamily", "go_ids": [], "go_terms": [], "name": "FlaG-like_sf", 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"R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", 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synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Homologous_superfamily"}, "IPR035926": {"description": "NusB-like superfamily", "go_ids": [], "go_terms": [], "name": "NusB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035927": {"description": "DUSP-like superfamily", "go_ids": [], "go_terms": [], "name": "DUSP-like_sf", "pathway_ids": ["R-HSA-2173788", "R-DRE-5689880", "R-MMU-5357786", "R-HSA-390471", "R-BTA-5357956", "R-BTA-5689880", "R-BTA-5357786", "R-SPO-5656169", "R-HSA-5689880", "R-HSA-9010553", "R-MMU-9010553", "R-RNO-5357905", "R-MMU-5357956", "R-HSA-5357786", "R-RNO-5689880", "R-CEL-5689880", "R-MMU-5689880", "R-BTA-9010553", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357905", "R-RNO-5357956", "R-HSA-5689603", "R-RNO-5357786", "R-XTR-5689880", "R-BTA-5357905"], "pathways": ["R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5689603:r:UCH proteinases", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-XTR-5689880:r:Ub-specific processing proteases", "R-BTA-5357905:r:Regulation of TNFR1 signaling"], "type": "Homologous_superfamily"}, "IPR035929": {"description": "CoaB-like superfamily", "go_ids": [], "go_terms": [], "name": "CoaB-like_sf", "pathway_ids": ["PWY-7851", "PWY-8342", "R-MMU-196783", "R-SPO-196783", "R-SCE-196783", "R-HSA-196783"], "pathways": ["PWY-7851:t:coenzyme A biosynthesis II (eukaryotic)", "PWY-8342:t:coenzyme A biosynthesis III (archaea)", "R-MMU-196783:r:Coenzyme A biosynthesis", "R-SPO-196783:r:Coenzyme A biosynthesis", "R-SCE-196783:r:Coenzyme A biosynthesis", "R-HSA-196783:r:Coenzyme A biosynthesis"], "type": "Homologous_superfamily"}, "IPR035930": {"description": "FomD-like superfamily", "go_ids": [], "go_terms": [], "name": "FomD-like_sf", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Homologous_superfamily"}, "IPR035931": {"description": "YlxR-like superfamily", "go_ids": [], "go_terms": [], "name": "YlxR-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035932": {"description": "HflD-like superfamily", "go_ids": [], "go_terms": [], "name": "HflD-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035933": {"description": "Hypothetical protein MTH1880", "go_ids": [], "go_terms": [], "name": "MTH1880", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035934": {"description": "Phage tail protein-like superfamily", "go_ids": [], "go_terms": [], "name": "Phage_tail_protein-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035935": {"description": "TFB5-like superfamily", "go_ids": [], "go_terms": [], "name": "TFB5-like_sf", "pathway_ids": ["R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-CEL-73776", "R-MMU-76042", "R-SPO-75953", "R-BTA-73863", "R-BTA-75955", "R-SPO-113418", "R-BTA-75953", "R-DDI-73779", "R-BTA-72086", "R-BTA-6782135", "R-DDI-6781823", "R-DDI-72086", "R-CEL-113418", "R-CEL-6782210", "R-MMU-674695", "R-SCE-76042", "R-CEL-6781823", "R-HSA-167161", "R-CEL-674695", "R-HSA-167200", "R-CEL-112382", "R-CEL-6782135", "R-SCE-674695", "R-DDI-77075", "R-HSA-167160", "R-HSA-5696395", "R-CEL-5696395", "R-DDI-113418", "R-BTA-6782210", "R-MMU-73772", "R-MMU-6782210", "R-MMU-72086", "R-SPO-73779", "R-BTA-73776", "R-BTA-73772", "R-SPO-73776", "R-CEL-6796648", "R-SCE-73776", "R-SCE-6782135", "R-DDI-6782135", "R-MMU-73762", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-BTA-113418", "R-CEL-72086", "R-HSA-72086", "R-CEL-73772", "R-HSA-167162", "R-BTA-6781823", "R-MMU-6781823", "R-GGA-353303", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-BTA-5696395", "R-BTA-5696400", "R-SCE-6782210", "R-HSA-167172", "R-BTA-6796648", "R-MMU-5696400", "R-BTA-73779", "R-SCE-6796648", "R-BTA-73762", "R-SCE-73779", "R-SPO-77075", "R-CEL-75955", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-SCE-6781823", "R-MMU-73863", "R-HSA-6782135", "R-BTA-674695", "R-HSA-73762", "R-CEL-77075", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-SCE-77075", "R-SPO-5696400", "R-SPO-6782210", "R-HSA-5696400", "R-DDI-75953", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-SPO-6782135", "R-CEL-76042", "R-HSA-112382", "R-HSA-73779", "R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-MMU-113418", "R-HSA-427413", "R-BTA-76042", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-HSA-167246", "R-MMU-5696395", "R-SPO-5696395", "R-HSA-73776", "R-SPO-76042", "R-BTA-77075", "R-DDI-674695", "R-HSA-75953", "R-CEL-75953"], "pathways": ["R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72086:r:mRNA Capping", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-353303:r:Nucleotide Excision Repair", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation"], "type": "Homologous_superfamily"}, "IPR035936": {"description": "BB2672 superfamily", "go_ids": [], "go_terms": [], "name": "BB2672", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035937": {"description": "Formamidopyrimidine-DNA glycosylase, N-terminal", "go_ids": [], "go_terms": [], "name": "FPG_N", "pathway_ids": ["R-HSA-110331", "R-HSA-9629232", "R-MMU-110330", "R-MMU-5649702", "R-HSA-9616334", "R-MMU-110329", "R-HSA-110329", "R-HSA-110328", "R-HSA-9636003", "R-HSA-110330", "R-HSA-5649702", "R-MMU-110328", "R-MMU-110331"], "pathways": ["R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-9629232:r:Defective Base Excision Repair Associated with NEIL3", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-9616334:r:Defective Base Excision Repair Associated with NEIL1", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9636003:r:NEIL3-mediated resolution of ICLs", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-MMU-110331:r:Cleavage of the damaged purine"], "type": "Homologous_superfamily"}, "IPR035938": {"description": "Hemerythrin-like superfamily", "go_ids": [], "go_terms": [], "name": "Hemerythrin-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035940": {"description": "CAP superfamily", "go_ids": [], "go_terms": [], "name": "CAP_sf", "pathway_ids": ["R-HSA-1989781", "R-HSA-6798695", "R-DDI-6798695", "R-DDI-5683826", "R-CEL-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-DDI-2132295"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-5683826:r:Surfactant metabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-2132295:r:MHC class II antigen presentation"], "type": "Homologous_superfamily"}, "IPR035942": {"description": "Lp2179-like superfamily", "go_ids": [], "go_terms": [], "name": "Lp2179-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035943": {"description": "XisI-like superfamily", "go_ids": [], "go_terms": [], "name": "XisI-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035944": {"description": "YfbM-like super family", "go_ids": [], "go_terms": [], "name": "YfbM-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035945": {"description": "YhaI-like superfamily", "go_ids": [], "go_terms": [], "name": "YhaI-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035946": {"description": "YML108W-like superfamily", "go_ids": [], "go_terms": [], "name": "YML108W-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035947": {"description": "MG354-like superfamily", "go_ids": [], "go_terms": [], "name": "MG354-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035948": {"description": "YwqG-like superfamily", "go_ids": [], "go_terms": [], "name": "YwqG-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035949": {"description": "SopE-like, GEF domain superfamily", "go_ids": [], "go_terms": [], "name": "SopE-like_GEF_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035950": {"description": "XkdW-like superfamily", "go_ids": [], "go_terms": [], "name": "XkdW-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035951": {"description": "TM1622-like superfamily", "go_ids": [], "go_terms": [], "name": "TM1622-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035952": {"description": "Rhomboid-like superfamily", "go_ids": [], "go_terms": [], "name": "Rhomboid-like_sf", "pathway_ids": ["R-MMU-382556", "R-HSA-532668", "R-HSA-9931269", "R-DDI-5358346", "R-HSA-901032", "R-BTA-382556", "R-BTA-9931269", "R-HSA-9662834", "R-DME-382556", "R-HSA-382556", "R-HSA-6807878", "R-HSA-5678895", "R-DRE-8949664", "R-CEL-9931269", "R-MMU-6807878", "R-CEL-532668", "R-DME-532668", "R-CEL-5358346", "R-MMU-8949664", "R-HSA-8866654", "R-BTA-6807878", "R-CEL-382556", "R-MMU-5358346", "R-MMU-9931269", "R-HSA-5362768", "R-MMU-532668", "R-HSA-8949664", "R-BTA-532668", "R-RNO-8949664", "R-HSA-5358346"], "pathways": ["R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-5358346:r:Hedgehog ligand biogenesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-DRE-8949664:r:Processing of SMDT1", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-MMU-8949664:r:Processing of SMDT1", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-8949664:r:Processing of SMDT1", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-8949664:r:Processing of SMDT1", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Homologous_superfamily"}, "IPR035953": {"description": "Dextranase, N-terminal", "go_ids": [], "go_terms": [], "name": "Dextranase_N-ter", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035954": {"description": "MTH677-like superfamily", "go_ids": [], "go_terms": [], "name": "MTH677-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035956": {"description": "RimP, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RimP_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035957": {"description": "Crustacean CHH/MIH/GIH neurohormone superfamily", "go_ids": [], "go_terms": [], "name": 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"R-BTA-373752", "R-HSA-354192", "R-MMU-8854691", "R-RNO-112411", "R-HSA-9013420", "R-SSC-9027276", "R-SSC-9020956", "R-MMU-8984722", "R-HSA-9662361", "R-MMU-6794361", "R-HSA-9031525", "R-DRE-9020958", "R-HSA-354194", "R-HSA-9679191", "R-HSA-1433557", "R-MMU-9006335", "R-MMU-877300", "R-CEL-2029482", "R-HSA-9705462", "R-MMU-983168", "R-HSA-9022699", "R-MMU-9696270", "R-HSA-9696273", "R-HSA-2453902"], "pathways": ["R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-9020591:r:Interleukin-12 signaling", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-5675221:r:Negative regulation of MAPK pathway", 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activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-437239:r:Recycling pathway of L1", "R-MMU-5673000:r:RAF activation", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-354192:r:Integrin signaling", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-DRE-877312:r:Regulation of IFNG signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-9020591:r:Interleukin-12 signaling", "R-RNO-354192:r:Integrin signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-DME-6794361:r:Neurexins and neuroligins", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-877300:r:Interferon gamma signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DRE-1266695:r:Interleukin-7 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 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"R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-6794361:r:Neurexins and neuroligins", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-MMU-114608:r:Platelet degranulation", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-877312:r:Regulation of IFNG signaling", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-DRE-1059683:r:Interleukin-6 signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-445355:r:Smooth Muscle Contraction", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-5673000:r:RAF activation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5673000:r:RAF activation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-SSC-982772:r:Growth hormone receptor signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-RNO-5673000:r:RAF activation", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-182971:r:EGFR downregulation", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-DME-114608:r:Platelet degranulation", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-DRE-8983432:r:Interleukin-15 signaling", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-DME-373752:r:Netrin-1 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-6794361:r:Neurexins and neuroligins", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-MMU-8983432:r:Interleukin-15 signaling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DRE-6783783:r:Interleukin-10 signaling", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-MMU-9020933:r:Interleukin-23 signaling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-9020558:r:Interleukin-2 signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-982772:r:Growth hormone receptor signaling", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CEL-114608:r:Platelet degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-DRE-446353:r:Cell-extracellular matrix interactions", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-MMU-69231:r:Cyclin D associated events in G1", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-449836:r:Other interleukin signaling", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CEL-418885:r:DCC mediated attractive signaling", "R-BTA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-373752:r:Netrin-1 signaling", "R-BTA-373752:r:Netrin-1 signaling", "R-HSA-354192:r:Integrin signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9013420:r:RHOU GTPase cycle", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-DRE-9020958:r:Interleukin-21 signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-MMU-877300:r:Interferon gamma signaling", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Homologous_superfamily"}, "IPR035964": {"description": "I/LWEQ domain superfamily", "go_ids": ["GO:0003779"], "go_terms": ["GO:0003779:actin binding:F"], "name": "I/LWEQ_dom_sf", "pathway_ids": ["R-CEL-8856828", "R-MMU-8856828", "R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-9700645", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-8856828", "R-MMU-399955", "R-HSA-9656223", "R-MMU-432722", "R-CEL-432722", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-DDI-114608", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-9725370", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-HSA-432722", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR035965": {"description": "PAS domain superfamily", "go_ids": [], "go_terms": [], "name": "PAS-like_dom_sf", "pathway_ids": ["R-RNO-193807", "R-DME-1296072", "R-DRE-211976", "R-DRE-192105", "R-CEL-211945", "R-HSA-8951664", "R-HSA-5689880", "R-RNO-5687128", "R-DRE-400206", "R-RNO-9018519", "R-CEL-418555", "R-MMU-5689880", "R-CEL-1234176", "R-HSA-9844594", "R-HSA-9931530", "R-DDI-5673000", "R-RNO-8857538", "R-HSA-9701898", "R-HSA-2122947", "R-HSA-1234176", "R-DME-432524", "R-DME-538898", "R-MMU-9932298", "R-HSA-418555", "R-HSA-9931521", "R-HSA-192105", "R-HSA-452723", "R-MMU-1234176", "R-RNO-5689880", "R-RNO-211945", "R-DME-432620", "R-DDI-5674135", "R-DME-432408", "R-MMU-211976", "R-RNO-8951664", "R-DME-211945", "R-DME-1234176", "R-RNO-9841922", "R-HSA-9931529", "R-DRE-9707564", "R-MMU-5687128", "R-HSA-9768919", "R-HSA-9664873", "R-MMU-193807", "R-HSA-8857538", "R-HSA-5576890", "R-MMU-5576890", "R-RNO-1234176", "R-DRE-9768919", "R-RNO-9932298", "R-DME-432553", "R-DME-418555", "R-HSA-211945", "R-HSA-1234174", "R-DRE-193368", "R-HSA-193368", "R-MMU-8937144", "R-DME-1234158", "R-HSA-5625886", "R-DME-432490", "R-DME-9768919", "R-DME-8937144", "R-MMU-9029569", "R-MMU-3214847", "R-DRE-8937144", "R-RNO-400206", "R-MMU-193368", "R-MMU-3899300", "R-HSA-381340", "R-HSA-9707616", "R-DME-432626", "R-DDI-5675221", "R-CEL-5689880", "R-HSA-9909649", "R-RNO-3214847", "R-DME-9932298", "R-HSA-1296072", "R-DRE-211945", "R-HSA-3214847", "R-HSA-159418", "R-HSA-2426168", "R-MMU-418555", "R-MMU-9707564", "R-CEL-8951664", "R-SSC-5576890", "R-HSA-1989781", "R-HSA-211981", "R-MMU-1234174", "R-DRE-193807", "R-HSA-2151201", "R-CFA-5576890", "R-HSA-1234158", "R-DME-8951664", "R-HSA-9932298", "R-RNO-211981", "R-HSA-1368108", "R-HSA-9841922", "R-SSC-1296072", "R-MMU-8951664", "R-MMU-1234158", "R-HSA-9933387", "R-HSA-9707564", "R-DRE-3214847", "R-HSA-9018519", "R-DRE-211981", "R-RNO-8937144", "R-DRE-5625886", "R-MMU-192105", "R-RNO-1234174", "R-HSA-6785807", "R-HSA-193807", "R-MMU-9018519", "R-DRE-159418", "R-HSA-9768778", "R-MMU-9768919", "R-RNO-211976", "R-RNO-193368", "R-HSA-400206", "R-CEL-8937144", "R-HSA-211976", "R-MMU-400206", "R-HSA-9623433", "R-MMU-211945", "R-HSA-5617472", "R-RNO-5576890", "R-BTA-1296072", "R-RNO-192105", "R-DME-432560", "R-MMU-211981", "R-MMU-8857538", "R-RNO-159418", "R-RNO-5625886", "R-HSA-8849473", "R-MMU-5625886", "R-HSA-9029569", "R-HSA-9931509", "R-HSA-8937144", "R-MMU-1296072", "R-CEL-1234158", "R-RNO-9768919", "R-MMU-9623433", "R-CFA-1296072", "R-RNO-9707564", "R-RNO-1296072", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-5687128", "R-DME-432395", "R-RNO-1234158", "R-HSA-3899300", "R-CEL-9768919", "R-MMU-159418", "R-DME-432501"], "pathways": ["R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DME-1296072:r:Voltage gated Potassium channels", "R-DRE-211976:r:Endogenous sterols", "R-DRE-192105:r:Synthesis of bile acids and bile salts", "R-CEL-211945:r:Phase I - Functionalization of compounds", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-CEL-418555:r:G alpha (s) signalling events", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-DDI-5673000:r:RAF activation", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-432524:r:Degradation of PER", "R-DME-538898:r:Dephosphorylation of TIM", "R-MMU-9932298:r:Degradation of CRY and 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"R-HSA-9931529:r:Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9664873:r:Pexophagy", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-5576890:r:Phase 3 - rapid repolarisation", "R-MMU-5576890:r:Phase 3 - rapid repolarisation", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-9768919:r:NPAS4 regulates expression of target genes", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-418555:r:G alpha (s) signalling events", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-HSA-1234174:r:Cellular response to hypoxia", "R-DRE-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", 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"R-MMU-211945:r:Phase I - Functionalization of compounds", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-5576890:r:Phase 3 - rapid repolarisation", "R-BTA-1296072:r:Voltage gated Potassium channels", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-DME-432560:r:Transcription activation by CLK:CYC and repression by VRI", "R-MMU-211981:r:Xenobiotics", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-8849473:r:PTK6 Expression", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling", "R-MMU-1296072:r:Voltage gated Potassium channels", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-9768919:r:NPAS4 regulates expression of target genes", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-CFA-1296072:r:Voltage gated Potassium channels", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-RNO-1296072:r:Voltage gated Potassium channels", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-432395:r:Degradation of TIM", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-CEL-9768919:r:NPAS4 regulates expression of target genes", "R-MMU-159418:r:Recycling of bile acids and salts", "R-DME-432501:r:Transcription repression by PER and activation by PDP1"], "type": "Homologous_superfamily"}, "IPR035966": {"description": "Phosphofructokinase superfamily", "go_ids": ["GO:0003872", "GO:0006096"], "go_terms": ["GO:0003872:6-phosphofructokinase activity:F", "GO:0006096:glycolytic process:P"], "name": "PKF_sf", "pathway_ids": ["PWY-5484", "PWY-1861", "PWY-1042", "PWY-7385", "R-RNO-6798695", "R-HSA-6798695", "R-SPO-6798695", "R-MMU-70171", "R-SCE-70171", "R-DME-6798695", "R-BTA-70171", "R-CEL-6798695", "R-SCE-6798695", "R-DME-70171", "R-BTA-6798695", "R-CEL-70171", "R-RNO-70171", "R-MMU-6798695", "R-HSA-70171", "R-SPO-70171"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1042:t:glycolysis IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil 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interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-MMU-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-RNO-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-173736:r:Alternative complement activation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-913709:r:O-linked glycosylation of mucins", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-MMU-114608:r:Platelet degranulation", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-BTA-173736:r:Alternative complement activation", "R-RNO-166662:r:Lectin pathway of complement activation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-BTA-3000178:r:ECM proteoglycans", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", 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"R-SPO-4085377", "R-HSA-450408", "R-HSA-749476", "R-SCE-166208", "R-HSA-6802955", "R-RNO-450408", "R-HSA-9694686", "R-DME-9772755", "R-XTR-77588", "R-HSA-6803529", "R-CEL-674695", "R-HSA-72163", "R-DRE-159227", "R-HSA-450604", "R-RNO-3232142", "R-DDI-113418", "R-RNO-9841922", "R-MMU-111367", "R-MMU-3108214", "R-MMU-72086", "R-SPO-159227", "R-CEL-8936459", "R-HSA-5578749", "R-CEL-9629569", "R-DME-72649", "R-SPO-9615933", "R-XTR-72702", "R-RNO-9930044", "R-HSA-8849468", "R-CEL-77595", "R-DME-9770562", "R-HSA-166208", "R-MMU-72200", "R-XTR-159236", "R-MMU-9013408", "R-DME-75955", "R-MMU-112382", "R-RNO-73856", "R-HSA-5673000", "R-MMU-4551638", "R-CEL-975956", "R-DDI-674695", "R-HSA-9824594", "R-RNO-1855183", "R-MMU-72163", "R-HSA-429947", "R-HSA-72702", "R-DRE-3371453", "R-HSA-9696264", "R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-HSA-2980766", "R-DRE-6803529", "R-HSA-9820841", "R-RNO-9696264", "R-SPO-72689", "R-MMU-5675221", "R-HSA-1839117", "R-RNO-4615885", "R-HSA-6781827", "R-HSA-9772755", "R-XTR-9770562", "R-RNO-77595", "R-DME-73779", "R-HSA-9682706", "R-CEL-983168", "R-DRE-191859", "R-HSA-6790901", "R-HSA-159227", "R-HSA-9013423", "R-HSA-9820865", "R-DRE-9770562", "R-HSA-6782315", "R-MMU-9772755", "R-GGA-6791226", "R-HSA-4086398", "R-DME-3108214", "R-SCE-72695", "R-MMU-72695", "R-RNO-113418", "R-HSA-8943723", "R-DME-72689", "R-RNO-72702", "R-HSA-72649", "R-MMU-156827", "R-PFA-72163", "R-RNO-111367", "R-MMU-1660499", "R-MMU-72187", "R-RNO-9770562", "R-HSA-111465", "R-DME-8941326", "R-DRE-9013422", "R-BTA-6807505", "R-BTA-72203", "R-SPO-72163", "R-HSA-112382", "R-CEL-3371453", "R-HSA-73779", "R-MMU-72203", "R-CEL-975957", "R-DME-6781823", "R-HSA-72187", "R-BTA-72689", "R-DRE-6807505", "R-HSA-975956", "R-HSA-159230", "R-RNO-159230", "R-HSA-9649948", "R-BTA-72695", "R-HSA-5655302", "R-HSA-4551638", "R-RNO-3899300", "R-HSA-9629569", "R-RNO-975957", "R-MMU-8936459", "R-CEL-6807505", "R-DME-3371453", "R-DRE-72695", "R-RNO-72203", "R-DME-9629569", "R-HSA-8950505", "R-DDI-72086", "R-MMU-674695", "R-SPO-77595", "R-HSA-2151209", "R-CEL-156827", "R-HSA-3301854", "R-HSA-9013149", "R-HSA-9768778", "R-XTR-9930044", "R-HSA-9854907", "R-SCE-674695", "R-SPO-156827", "R-MMU-6804115", "R-SPO-429947", "R-DME-450408", "R-DME-111367", "R-HSA-8853884", "R-CEL-111367", "R-RNO-3371453", "R-DME-156827", "R-DME-77595", "R-DRE-159231", "R-HSA-2559585", "R-BTA-77588", "R-CEL-72086", "R-HSA-72086", "R-CEL-73856", "R-DDI-9770562", "R-XTR-975956", "R-RNO-72689", "R-XTR-72165", "R-HSA-1912408", "R-SCE-975957", "R-HSA-3214841", "R-HSA-6802946", "R-HSA-167152", "R-HSA-77588", "R-HSA-111367", "R-HSA-9029569", "R-XTR-72695", "R-SCE-113418", "R-RNO-75094", "R-RNO-5250924", "R-DRE-975957", "R-DRE-3214841", "R-DME-8936459", "R-RNO-170822", "R-HSA-5687128", "R-MMU-166208", "R-MMU-9634638", "R-CEL-6803529", "R-MMU-429947", "R-SPO-9772755", "R-RNO-8856828", "R-CEL-72163", "R-HSA-4615885", "R-SSC-72165", "R-MMU-3371453", "R-HSA-72203", "R-XTR-73856", "R-MMU-3899300", "R-HSA-9696270", "R-HSA-168271", "R-DME-6798695", "R-HSA-381340", "R-XTR-72203", "R-BTA-9013422", "R-BTA-6803529", "R-HSA-167290", "R-DDI-77595", "R-HSA-9909620", "R-DME-6782210", "R-HSA-674695", "R-HSA-76042", "R-MMU-9696273", "R-DDI-156827", "R-CEL-8951664", "R-CEL-159236", "R-HSA-6798695", "R-HSA-2151201", "R-RNO-6807505", "R-RNO-3108214", "R-HSA-6781823", "R-MMU-159230", "R-HSA-75953", "R-CEL-4551638", "R-HSA-9759811", "R-DME-4615885", "R-HSA-9013408", "R-SPO-72086", "R-SPO-975956", "R-MMU-5250924", "R-RNO-156827", "R-SPO-72706", "R-DME-674695", "R-BTA-72086", "R-SCE-975956", "R-DME-159227", "R-DME-450520", "R-HSA-75094", "R-DME-6807505", "R-HSA-167200", "R-RNO-112382", "R-MMU-450604", "R-CEL-9930044", "R-HSA-159236", "R-BTA-72649", "R-DDI-9930044", "R-CEL-77588", "R-MMU-6803529", "R-DDI-975956", "R-SPO-6798695", "R-CEL-72702", "R-XTR-72163", "R-SSC-159236", "R-CEL-72695", "R-MMU-72649", "R-HSA-192823", "R-DDI-73856", "R-MMU-4085377", "R-HSA-113418", "R-RNO-6803529", "R-SPO-72203", "R-HSA-9937008", "R-DME-72695", "R-MMU-72702", "R-SCE-72086", "R-HSA-4085377", "R-CEL-8941326", "R-HSA-72689", "R-CEL-3214841", "R-SCE-72649", "R-DRE-3301854", "R-DDI-77588", "R-DRE-72689", "R-BTA-975956", "R-HSA-9692916", "R-HSA-5250924", "R-XTR-6807505", "R-MMU-450408", "R-RNO-9615933", "R-HSA-9013418", "R-HSA-9022692", "R-RNO-3301854", "R-SPO-975957", "R-HSA-167158", "R-MMU-75955", "R-BTA-159227", "R-MMU-9615933", "R-HSA-73776", "R-DME-73856", "R-DME-6782135", "R-SCE-72702", "R-BTA-72163", "R-MMU-6791226", "R-MMU-3214841", "R-MMU-5578749", "R-XTR-674695", "R-SCE-77595", "R-HSA-167242", "R-HSA-9609690", "R-HSA-8851708", "R-HSA-159231", "R-RNO-72649", "R-MMU-9013423", "R-HSA-167161", "R-RNO-4085377", "R-CEL-72649", "R-HSA-8986944", "R-HSA-426496", "R-DME-72702", "R-DME-426496", "R-CEL-72689", "R-HSA-9768919", "R-SPO-3371453", "R-HSA-9705671", "R-DME-429947", "R-MMU-72689", "R-SSC-72187", "R-DME-5578749", "R-CEL-3899300", "R-HSA-77595", "R-DRE-3108214", "R-MMU-6781823", "R-DRE-73856", "R-GGA-72163", "R-HSA-9843970", "R-HSA-165054", "R-XTR-77595", "R-HSA-72165", "R-GGA-9770562", "R-SSC-6803529", "R-HSA-167172", "R-HSA-8941326", "R-MMU-191859", "R-MMU-111465", "R-DME-113418", "R-MMU-975957", "R-HSA-2995383", "R-DME-9013422", "R-HSA-8939902", "R-HSA-975957", "R-DRE-72702", "R-RNO-1660499", "R-MMU-72165", "R-SSC-9770562", "R-XTR-72086", "R-MMU-9013149", "R-HSA-9692914", "R-DRE-72165", "R-HSA-1989781", "R-CEL-159231", "R-HSA-6804115", "R-HSA-9013422", "R-MMU-113418", "R-CEL-3301854", "R-HSA-8948700", "R-MMU-9013404", "R-DME-9930044", "R-RNO-72695", "R-MMU-9013422", "R-RNO-191859", "R-CEL-159230", "R-SPO-9696273", "R-BTA-429947", "R-HSA-9635465", "R-BTA-9013418", "R-HSA-9018519", "R-HSA-9610379", "R-BTA-450408", "R-DRE-450604", "R-DDI-72695", "R-HSA-6784531", "R-MMU-73856", "R-DDI-72203", "R-HSA-168325", "R-MMU-450520", "R-RNO-9696273", "R-CEL-113418", "R-RNO-429947", "R-BTA-9930044", "R-DDI-6807505", "R-HSA-9013404", "R-SPO-4570464", "R-DME-72165", "R-HSA-6791226", "R-RNO-975956", "R-HSA-5619107", "R-MMU-6782210", "R-DDI-72702", "R-MMU-6782135", "R-RNO-9696270", "R-DME-159236", "R-DME-6796648", "R-HSA-1169408", "R-HSA-5628897"], "pathways": ["R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-GGA-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-75094:r:Formation of the Editosome", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9696270:r:RND2 GTPase cycle", "R-RNO-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-DRE-9930044:r:Nuclear RNA decay", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-DME-72086:r:mRNA Capping", "R-HSA-72200:r:mRNA Editing: C to U Conversion", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9930044:r:Nuclear RNA decay", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-5673000:r:RAF activation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-168315:r:Inhibition of Host mRNA Processing and RNA Silencing", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-SCE-429947:r:Deadenylation of mRNA", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-428359:r:Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-166208:r:mTORC1-mediated signalling", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-MMU-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-9022707:r:MECP2 regulates transcription factors", "R-SPO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9707616:r:Heme signaling", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-SSC-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-9629569:r:Protein hydroxylation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-180746:r:Nuclear import of Rev protein", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-8941326:r:RUNX2 regulates bone development", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9841922:r:MLL4 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Termination", "R-SCE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-XTR-6803529:r:FGFR2 alternative splicing", "R-DDI-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-RNO-72086:r:mRNA Capping", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-72649:r:Translation initiation complex formation", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9930044:r:Nuclear RNA decay", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-XTR-113418:r:Formation of the Early Elongation Complex", "R-SSC-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-9696273:r:RND1 GTPase cycle", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-166208:r:mTORC1-mediated signalling", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-XTR-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-72086:r:mRNA Capping", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-CEL-9629569:r:Protein hydroxylation", "R-DME-72649:r:Translation initiation complex formation", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-9930044:r:Nuclear RNA decay", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-166208:r:mTORC1-mediated signalling", "R-MMU-72200:r:mRNA Editing: C to U Conversion", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9013408:r:RHOG GTPase cycle", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-5673000:r:RAF activation", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-DRE-6803529:r:FGFR2 alternative splicing", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-RNO-9696264:r:RND3 GTPase cycle", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-XTR-9770562:r:mRNA Polyadenylation", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-191859:r:snRNP Assembly", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-GGA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-4086398:r:Ca2+ pathway", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-PFA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-DME-8941326:r:RUNX2 regulates bone development", "R-DRE-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-72187:r:mRNA 3'-end processing", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9629569:r:Protein hydroxylation", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-9629569:r:Protein hydroxylation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-XTR-9930044:r:Nuclear RNA decay", "R-HSA-9854907:r:Regulation of MITF-M dependent genes involved in metabolism", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-SPO-429947:r:Deadenylation of mRNA", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-BTA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-XTR-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-RNO-75094:r:Formation of the Editosome", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-CEL-6803529:r:FGFR2 alternative splicing", "R-MMU-429947:r:Deadenylation of mRNA", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SSC-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-XTR-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-XTR-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9696273:r:RND1 GTPase cycle", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-8951664:r:Neddylation", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SPO-72086:r:mRNA Capping", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-75094:r:Formation of the Editosome", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", 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"IPR035980": {"description": "Small ribosomal subunit protein bS6 superfamily", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412", "GO:0019843"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P", "GO:0019843:rRNA binding:F"], "name": "Ribosomal_bS6_sf", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383", "R-DME-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", 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Ubiquitination & Proteasome degradation", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-RNO-8948747:r:Regulation of PTEN localization", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DME-5632684:r:Hedgehog 'on' state", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-9013420:r:RHOU GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-1253288:r:Downregulation of ERBB4 signaling"], "type": "Homologous_superfamily"}, "IPR035984": {"description": "Acyl-CoA binding protein superfamily", "go_ids": ["GO:0000062"], "go_terms": ["GO:0000062:fatty-acyl-CoA binding:F"], "name": "Acyl-CoA-binding_sf", "pathway_ids": ["R-XTR-9013106", "R-CEL-390918", "R-BTA-390918", "R-MMU-9013106", "R-RNO-390918", "R-MMU-8980692", "R-RNO-9603798", "R-RNO-8980692", "R-MMU-432722", "R-CEL-77289", "R-CFA-77289", "R-HSA-9013106", "R-RNO-9033241", "R-DRE-77289", "R-DRE-390918", "R-RNO-77289", "R-RNO-9013106", "R-MMU-9603798", "R-HSA-432722", "R-HSA-9603798", "R-RNO-432722", "R-HSA-77289", "R-DRE-9013106", "R-DME-77289", "R-BTA-77289", "R-MMU-9033241", "R-DDI-77289", "R-SCE-77289", "R-DRE-9603798", "R-HSA-390918", "R-MMU-390918", "R-XTR-8980692", "R-XTR-9603798", "R-HSA-8980692", "R-HSA-390247", "R-MMU-77289", "R-MMU-390247", "R-DRE-8980692", "R-SPO-77289", "R-XTR-390918", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-XTR-9013106:r:RHOC GTPase cycle", "R-CEL-390918:r:Peroxisomal lipid metabolism", "R-BTA-390918:r:Peroxisomal lipid metabolism", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-390918:r:Peroxisomal lipid metabolism", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-CFA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9013106:r:RHOC GTPase cycle", "R-RNO-9033241:r:Peroxisomal protein import", "R-DRE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DRE-390918:r:Peroxisomal lipid metabolism", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DRE-9013106:r:RHOC GTPase cycle", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SCE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DRE-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-MMU-390918:r:Peroxisomal lipid metabolism", "R-XTR-8980692:r:RHOA GTPase cycle", "R-XTR-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-DRE-8980692:r:RHOA GTPase cycle", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-XTR-390918:r:Peroxisomal lipid metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Homologous_superfamily"}, "IPR035985": {"description": "Ubiquitin-activating enzyme-like", "go_ids": ["GO:0008641"], "go_terms": ["GO:0008641:ubiquitin-like modifier activating enzyme activity:F"], "name": "Ubiquitin-activating_enz", "pathway_ids": ["R-BTA-983168", "R-HSA-6798695", "R-MMU-9909505", "R-GGA-1632852", "R-HSA-6802952", "R-HSA-8951664", "R-HSA-3065678", "R-MMU-1632852", "R-HSA-9918485", "R-HSA-5676590", "R-MMU-8866652", "R-SCE-3065678", "R-CEL-947581", "R-SPO-3065678", "R-SPO-947581", "R-DME-947581", "R-RNO-1632852", "R-HSA-8866652", "R-SSC-947581", "R-RNO-5607761", "R-BTA-3065678", "R-DDI-6798695", "R-SPO-3065676", "R-HSA-5607761", "R-MMU-3065676", "R-CEL-3065678", "R-GGA-6798695", "R-DRE-3065676", "R-SCE-1632852", "R-DRE-947581", "R-BTA-8866652", "R-HSA-1632852", "R-MMU-6798695", "R-CEL-3065676", "R-RNO-983168", "R-SPO-1632852", "R-RNO-6798695", "R-DDI-8866652", "R-GGA-983168", "R-SPO-6798695", "R-DME-983168", "R-RNO-5676590", "R-HSA-168928", "R-DRE-3065678", "R-SCE-6798695", "R-RNO-8866652", "R-HSA-936440", "R-HSA-1169408", "R-CEL-983168", "R-HSA-9909505", "R-HSA-947581", "R-DRE-983168", "R-DDI-3065676", "R-SPO-983168", "R-SCE-947581", "R-SCE-983168", "R-HSA-5656169", "R-MMU-3065678", "R-DDI-1169408", "R-DDI-1632852", "R-RNO-3065676", "R-DDI-936440", "R-MMU-947581", "R-BTA-3065676", "R-MMU-5656169", "R-HSA-983168", "R-MMU-1169408", "R-DDI-947581", "R-MMU-5607761", "R-MMU-5676590", "R-MTU-936654", "R-DDI-983168", "R-DDI-3065678", "R-DDI-9909505", "R-HSA-3065676", "R-XTR-983168", "R-SCE-3065676", "R-MMU-983168", "R-RNO-3065678", "R-BTA-947581"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-GGA-1632852:r:Macroautophagy", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-8951664:r:Neddylation", "R-HSA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-MMU-1632852:r:Macroautophagy", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-SCE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-CEL-947581:r:Molybdenum cofactor biosynthesis", "R-SPO-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SPO-947581:r:Molybdenum cofactor biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-1632852:r:Macroautophagy", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-SSC-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-BTA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-CEL-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-GGA-6798695:r:Neutrophil degranulation", "R-DRE-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-SCE-1632852:r:Macroautophagy", "R-DRE-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-1632852:r:Macroautophagy", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-1632852:r:Macroautophagy", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DRE-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-947581:r:Molybdenum cofactor biosynthesis", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-1632852:r:Macroautophagy", "R-RNO-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MTU-936654:r:Cysteine synthesis from O-phosphoserine", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-3065676:r:SUMO is conjugated to E1 (UBA2:SAE1)", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "R-BTA-947581:r:Molybdenum cofactor biosynthesis"], "type": "Homologous_superfamily"}, "IPR035986": {"description": "PKD domain superfamily", "go_ids": [], "go_terms": [], "name": "PKD_dom_sf", "pathway_ids": ["R-MMU-8856828", "R-HSA-5620916", "R-MMU-5620916", "R-RNO-8856825", "R-MMU-8857538", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-RNO-8856828", "R-RNO-8857538", "R-HSA-9824585", "R-HSA-8857538"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Homologous_superfamily"}, "IPR035987": {"description": "Small ribosomal subunit protein uS8 superfamily", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uS8_sf", "pathway_ids": ["R-DME-6791226", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-HSA-72695", "R-RNO-72695", "R-MMU-72706", "R-HSA-975956", "R-BTA-72689", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-BTA-72695", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-DRE-9954714", "R-DRE-72695", "R-SCE-975956", "R-DDI-72695", "R-BTA-6791226", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-RNO-6791226", "R-RNO-72649", "R-DRE-1799339", "R-HSA-6791226", "R-RNO-975956", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-SPO-72689", "R-DDI-72689", "R-DDI-72702", "R-MMU-1799339", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-DME-72649", "R-RNO-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-72695", "R-DME-975956", "R-MMU-72702", "R-DME-975957", "R-DRE-975956", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-HSA-72649", "R-HSA-9754678", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-DRE-72649", "R-SCE-72649", "R-HSA-975957", "R-DRE-72702", "R-DME-9954714", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-DDI-9954716", "R-RNO-9954714", "R-HSA-9633012", "R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72695:r:Formation of the ternary 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"R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-BTA-201688:r:WNT mediated activation of DVL", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Homologous_superfamily"}, "IPR035992": {"description": "Ricin B-like lectins", "go_ids": [], "go_terms": [], "name": "Ricin_B-like_lectins", "pathway_ids": ["R-HSA-9694719", "R-MMU-913709", "R-BTA-1482788", "R-HSA-9918485", "R-BTA-1482801", "R-HSA-1483166", "R-HSA-1482925", "R-HSA-1482922", "R-HSA-5083625", "R-MMU-1482788", "R-BTA-1483166", "R-DME-190372", "R-MMU-1482925", "R-RNO-913709", "R-RNO-1236978", "R-HSA-190372", "R-BTA-913709", "R-HSA-6811436", "R-HSA-9637628", "R-HSA-5083636", "R-DME-6811436", "R-CEL-6811436", "R-HSA-1236978", "R-BTA-1482839", "R-BTA-1482925", "R-MMU-190372", "R-MMU-1482839", "R-MMU-6811436", "R-HSA-1482801", "R-RNO-6811436", "R-MMU-1483166", "R-BTA-6811436", "R-MMU-1482922", "R-HSA-1482839", "R-CEL-913709", "R-XTR-913709", "R-BTA-1482922", "R-HSA-9683673", "R-MMU-1236978", "R-MMU-1482801", "R-DME-913709", "R-HSA-913709", "R-HSA-1482788"], "pathways": ["R-HSA-9694719:r:Maturation of protein 3a", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-BTA-1483166:r:Synthesis of PA", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-BTA-913709:r:O-linked glycosylation of mucins", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-1483166:r:Synthesis of PA", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-XTR-913709:r:O-linked glycosylation of mucins", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-HSA-9683673:r:Maturation of protein 3a", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-DME-913709:r:O-linked glycosylation of mucins", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Homologous_superfamily"}, "IPR035993": {"description": "Notch-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Notch-like_dom_sf", "pathway_ids": ["R-XTR-2979096", "R-HSA-8941856", "R-HSA-9604323", "R-HSA-2122948", "R-RNO-9017802", "R-MMU-2122947", "R-XTR-8941856", "R-MMU-2122948", "R-HSA-9818749", "R-XTR-2122948", "R-HSA-9824272", "R-XTR-2197563", "R-XTR-1912420", "R-HSA-1912408", "R-RNO-350054", "R-MMU-1912420", "R-HSA-5083630", "R-HSA-2979096", "R-HSA-9017802", "R-HSA-9818030", "R-HSA-9013700", "R-MMU-9013507", "R-RNO-1912420", "R-HSA-2691232", "R-HSA-9013507", "R-HSA-2122947", "R-MMU-9013700", "R-HSA-1912420", "R-HSA-9013508", "R-CEL-2979096", "R-HSA-210744", "R-HSA-2894862", "R-XTR-9013507", "R-RNO-9013507", "R-MMU-9017802", "R-HSA-350054", "R-MMU-9604323", "R-HSA-9013695", "R-HSA-2644607", "R-HSA-2660826", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-1912399", "R-XTR-9017802"], "pathways": ["R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9824272:r:Somitogenesis", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-CEL-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-XTR-9017802:r:Noncanonical activation of NOTCH3"], "type": "Homologous_superfamily"}, "IPR035994": {"description": "Nucleoside phosphorylase superfamily", "go_ids": ["GO:0003824", "GO:0009116"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0009116:nucleoside metabolic process:P"], "name": "Nucleoside_phosphorylase_sf", "pathway_ids": ["R-HSA-6798695", "R-PFA-73621", "R-SPO-6798695", "R-SCE-9755088", "R-RNO-74259", "R-SCE-6798695", "R-PFA-73614", "R-HSA-1237112", "R-MMU-9755088", "R-SCE-74217", "R-BTA-1237112", "R-SPO-1237112", "R-HSA-74259", "R-MMU-74217", "R-MMU-1237112", "R-HSA-9755088", "R-HSA-9735763", "R-CEL-73621", "R-CEL-1237112", "R-DME-1237112", "R-CEL-73614", "R-HSA-73614", "R-RNO-74217", "R-RNO-9755088", "R-HSA-8950505", "R-MMU-73614", "R-HSA-73621", "R-DRE-1237112", "R-SCE-1237112", "R-SPO-9755088", "R-HSA-74217", "R-MMU-6798695", "R-MMU-74259", "R-SCE-74259", "R-SPO-74259", "R-SPO-74217", "R-MMU-73621", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-PFA-73621:r:Pyrimidine catabolism", "R-SPO-6798695:r:Neutrophil degranulation", "R-SCE-9755088:r:Ribavirin ADME", "R-RNO-74259:r:Purine catabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-PFA-73614:r:Pyrimidine salvage", "R-HSA-1237112:r:Methionine salvage pathway", "R-MMU-9755088:r:Ribavirin ADME", "R-SCE-74217:r:Purine salvage", "R-BTA-1237112:r:Methionine salvage pathway", "R-SPO-1237112:r:Methionine salvage pathway", "R-HSA-74259:r:Purine catabolism", "R-MMU-74217:r:Purine salvage", "R-MMU-1237112:r:Methionine salvage pathway", "R-HSA-9755088:r:Ribavirin ADME", "R-HSA-9735763:r:Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine", "R-CEL-73621:r:Pyrimidine catabolism", "R-CEL-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-CEL-73614:r:Pyrimidine salvage", "R-HSA-73614:r:Pyrimidine salvage", "R-RNO-74217:r:Purine salvage", "R-RNO-9755088:r:Ribavirin ADME", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-DRE-1237112:r:Methionine salvage pathway", "R-SCE-1237112:r:Methionine salvage pathway", "R-SPO-9755088:r:Ribavirin ADME", "R-HSA-74217:r:Purine salvage", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-74259:r:Purine catabolism", "R-SCE-74259:r:Purine catabolism", "R-SPO-74259:r:Purine catabolism", "R-SPO-74217:r:Purine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR035995": {"description": "Bowman-Birk type proteinase inhibitor", "go_ids": ["GO:0004867", "GO:0005576"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F", "GO:0005576:extracellular region:C"], "name": "Bowman-Birk_prot_inh", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR035996": {"description": "Tetrapyrrole methylase superfamily", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "4pyrrol_Methylase_sf", "pathway_ids": ["R-SPO-5358493", "R-SCE-5358493", "R-BTA-5358493", "R-DDI-5358493", "R-HSA-5358493", "R-MMU-5358493"], "pathways": ["R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Homologous_superfamily"}, "IPR035999": {"description": "Sec7 domain superfamily", "go_ids": ["GO:0005085", "GO:0032012"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0032012:regulation of ARF protein signal transduction:P"], "name": "Sec7_dom_sf", "pathway_ids": ["R-SPO-6807878", "R-SPO-199992", "R-CEL-199992", "R-HSA-6811438", "R-MMU-6811438", "R-SCE-6807878", "R-SCE-6811434", "R-MMU-5620916", "R-HSA-390471", "R-DDI-9907900", "R-RNO-6811438", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-HSA-199992", "R-HSA-5620916", "R-HSA-6811434", "R-SPO-6811438", "R-SPO-5620916", "R-HSA-9918476", "R-SPO-6811434", "R-SCE-6811438", "R-MMU-199992", "R-CEL-5620916", "R-CEL-6811438", "R-SCE-5620916", "R-HSA-9918481", "R-CEL-6811434", "R-SCE-199992", "R-HSA-9768919", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-SPO-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811438:r:Intra-Golgi traffic", "R-SPO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811438:r:Intra-Golgi traffic", "R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-6811438:r:Intra-Golgi traffic", "R-SCE-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR036001": {"description": "Photosystem antenna protein-like superfamily", "go_ids": ["GO:0009521", "GO:0009767", "GO:0016020", "GO:0016168", "GO:0019684"], "go_terms": ["GO:0009521:photosystem:C", "GO:0009767:photosynthetic electron transport chain:P", "GO:0016020:membrane:C", "GO:0016168:chlorophyll binding:F", "GO:0019684:photosynthesis, light reaction:P"], "name": "PS_II_antenna-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036002": {"description": "Stathmin superfamily", "go_ids": ["GO:0031110"], "go_terms": ["GO:0031110:regulation of microtubule polymerization or depolymerization:P"], "name": "Stathmin_sf", "pathway_ids": ["R-MMU-9696273", "R-HSA-1251985", "R-HSA-9696273", "R-RNO-9696273"], "pathways": ["R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036005": {"description": "Creatinase/aminopeptidase-like", "go_ids": [], "go_terms": [], "name": "Creatinase/aminopeptidase-like", "pathway_ids": ["R-HSA-6798695", "R-MMU-163125", "R-SPO-6798695", "R-SPO-674695", "R-HSA-167238", "R-SCE-163125", "R-SCE-6798695", "R-DDI-163125", "R-DME-6796648", "R-SCE-6804756", "R-BTA-2514859", "R-MMU-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-HSA-112382", "R-DDI-674695", "R-HSA-167152", "R-MMU-2514859", "R-DDI-6796648", "R-DDI-6804756", "R-CEL-6804756", "R-SPO-6796648", "R-DRE-2514859", "R-SCE-6796648", "R-DDI-6798695", "R-CEL-75955", "R-MMU-6796648", "R-HSA-2514859", "R-DME-674695", "R-HSA-167243", "R-SPO-2514859", "R-DDI-2514859", "R-MMU-674695", "R-RNO-163125", "R-DME-6804756", "R-HSA-163125", "R-XTR-2514859", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-HSA-167290", "R-HSA-6804756", "R-HSA-75955", "R-CEL-112382", "R-SCE-674695", "R-MMU-6798695", "R-HSA-674695", "R-CEL-2514859", "R-CEL-6796648", "R-SCE-2514859", "R-GGA-2514859", "R-RNO-2514859", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-6798695:r:Neutrophil degranulation", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-XTR-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-GGA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036008": {"description": "Aconitase, iron-sulfur domain", "go_ids": [], "go_terms": [], "name": "Aconitase_4Fe-4S_dom", "pathway_ids": ["R-DDI-9837999", "R-MMU-71403", "R-CEL-917937", "R-HSA-9854311", "R-CEL-389542", "R-MMU-9837999", "R-CEL-9837999", 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"R-HSA-5607764", "R-MMU-112308", "R-XTR-8875656", "R-HSA-9028731", "R-HSA-354192", "R-XTR-8851805", "R-HSA-193648", "R-RNO-1963640", "R-HSA-8964616", "R-MMU-6794361", "R-HSA-354194", "R-XTR-9013424", "R-MMU-181429", "R-GGA-432142", "R-DME-212676", "R-RNO-389356", "R-CEL-2029482", "R-HSA-1236394", "R-BTA-1433559", "R-BTA-2730905", "R-HSA-5687128", "R-DME-9841922", "R-BTA-422356", "R-RNO-5654720", "R-MMU-2424491", "R-DRE-1295596", "R-MMU-8849472", "R-DME-4420097", "R-RNO-1236973", "R-HSA-9013405", "R-SSC-9766229", "R-MMU-180336", "R-MMU-5654720", "R-RNO-2028269", "R-BTA-1227986", "R-HSA-69231", "R-HSA-9027284", "R-RNO-512988", "R-RNO-2871809", "R-CEL-5654219", "R-MMU-5654221", "R-MMU-5689880", "R-MMU-201556", "R-RNO-177504", "R-HSA-512988", "R-XTR-1433557", "R-CEL-182971", "R-RNO-416476", "R-DME-5663213", "R-XTR-5654726", "R-DME-9607240", "R-MMU-9013407", "R-MMU-170968", "R-RNO-9705462", "R-DRE-186763", "R-XTR-9013148", "R-CEL-456926", "R-HSA-389356", "R-HSA-399954", "R-DRE-8980692", "R-RNO-5621575", "R-DME-1963642", "R-RNO-9013420", "R-HSA-179812", "R-XTR-74749", "R-RNO-2871796", "R-BTA-1660499", "R-SSC-6798695", "R-MMU-187577", "R-CEL-1227986", "R-DME-432553", "R-HSA-6803205", "R-CEL-5654227", "R-HSA-8849468", "R-MMU-5693565", "R-MMU-196108", "R-XTR-5673001", "R-BTA-9927354", "R-XTR-975578", "R-MMU-5654704", "R-MMU-75892", "R-RNO-8856828", "R-GGA-9013149", "R-SSC-389513", "R-RNO-437239", "R-DME-6798695", "R-HSA-5654726", "R-DME-2179392", "R-DME-5218900", "R-MMU-9013424", "R-MMU-210500", "R-CEL-2454202", "R-RNO-5654689", "R-RNO-3928664", "R-DME-74749", "R-XTR-5654732", "R-DME-975578", "R-GGA-3928665", "R-BTA-9696264", "R-RNO-389948", "R-DME-6794361", "R-BTA-210993", "R-DRE-193648", "R-XTR-5654689", "R-DRE-418592", "R-MMU-1222556", "R-RNO-112308", "R-CEL-6798695", "R-BTA-6798695", "R-HSA-9670439", "R-MMU-8865999", "R-MMU-432142", "R-RNO-912526", "R-DME-2029482", "R-HSA-5576893", "R-RNO-202427", "R-BTA-8866376", "R-CEL-451308", "R-BTA-8853659", "R-CEL-5654700", "R-MMU-2029485", "R-RNO-9013404", "R-XTR-182971", "R-HSA-9013408", "R-CEL-3928662", "R-HSA-1266695", "R-RNO-9927354", "R-MMU-2428933", "R-HSA-9706374", "R-DRE-418594", "R-DRE-1253288", "R-HSA-3928664", "R-RNO-3928663", "R-HSA-264642", "R-GGA-9013423", "R-CEL-8939236", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-DME-2871796", "R-CEL-212718", "R-DRE-399956", "R-SSC-389359", "R-HSA-1257604", "R-MMU-5654710", "R-HSA-2132295", "R-HSA-74751", "R-DME-5654693", "R-DME-525793", "R-HSA-1251932", "R-MMU-203641", "R-SPO-8941237", "R-HSA-1250347", "R-CEL-1251985", "R-HSA-6794361", "R-MMU-198203", "R-RNO-5663213", "R-HSA-9673770", "R-BTA-201556", "R-HSA-9035034", "R-HSA-8849473", "R-DME-9013409", "R-XTR-5654700", "R-HSA-8851805", "R-MMU-5218921", "R-BTA-2029485", "R-BTA-9013420", "R-RNO-5654706", "R-MMU-2028269", "R-MMU-428890", "R-SSC-2424491", "R-RNO-982772", "R-HSA-983168", "R-MMU-9033241", "R-HSA-9673324", "R-MMU-2029482", "R-DME-451308", "R-BTA-8856825", "R-SSC-5673001", "R-RNO-2424491", "R-RNO-8941858", "R-SSC-3928665", "R-HSA-390522", "R-RNO-5654700", "R-HSA-202424", "R-HSA-389948", "R-MMU-399719", "R-HSA-9033241", "R-HSA-5663213", "R-RNO-8948751", "R-MMU-1266695", "R-BTA-9696273", "R-MMU-114604", "R-HSA-9833482", "R-RNO-2428933", "R-HSA-167021", "R-RNO-9607240", "R-XTR-2730905", "R-CEL-5621575", "R-CEL-5654695", "R-HSA-8939245", "R-RNO-6811558", "R-MMU-8851805", "R-MMU-5576893", "R-DME-74751", "R-HSA-9603381", "R-DME-3928664", "R-HSA-447038", "R-DDI-9033241", "R-GGA-9013420", "R-GGA-8875555", "R-HSA-5654727", "R-XTR-9013408", "R-MMU-3299685", "R-MMU-9013423", "R-HSA-5654699", "R-RNO-8875656", "R-HSA-1295596", "R-RNO-8851805", "R-RNO-9006335", "R-MMU-5682910", "R-HSA-1236974", "R-HSA-9768727", "R-SSC-1433557", "R-RNO-6798695", "R-HSA-9656223", "R-BTA-2029482", "R-MMU-8934903", "R-RNO-9842663", "R-MMU-5654699", "R-BTA-202427", "R-DRE-438066", "R-RNO-75892", "R-RNO-1253288", "R-HSA-181429", "R-HSA-5620916", "R-MMU-8847993", "R-HSA-2730905", "R-MMU-6804759", "R-MMU-9027284", "R-BTA-1433557", "R-HSA-9020558", "R-CEL-9013423", "R-BTA-512988", "R-DME-5654699"], "pathways": ["R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-912631:r:Regulation of signaling by CBL", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DME-112412:r:SOS-mediated signalling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-BTA-9607240:r:FLT3 Signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-182971:r:EGFR downregulation", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-SPO-5689901:r:Metalloprotease DUBs", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-BTA-373753:r:Nephrin family interactions", "R-GGA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-114604:r:GPVI-mediated activation cascade", "R-HSA-432142:r:Platelet sensitization by LDL", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DRE-191650:r:Regulation of gap junction activity", "R-GGA-9013106:r:RHOC GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-XTR-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-GGA-8875656:r:MET receptor recycling", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-164944:r:Nef and signal transduction", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-DME-445095:r:Interaction between L1 and Ankyrins", "R-XTR-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-977443:r:GABA receptor activation", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-3928664:r:Ephrin signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-XTR-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-9013408:r:RHOG GTPase cycle", "R-SSC-1433559:r:Regulation of KIT signaling", "R-CEL-6807004:r:Negative regulation of MET activity", "R-XTR-186763:r:Downstream signal transduction", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-844456:r:The NLRP3 inflammasome", "R-GGA-1433559:r:Regulation of KIT signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-418594:r:G alpha (i) signalling events", "R-GGA-8964616:r:G beta:gamma signalling through CDC42", "R-GGA-170984:r:ARMS-mediated activation", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-XTR-8853659:r:RET signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-XTR-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-198203:r:PI3K/AKT activation", "R-XTR-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-GGA-416482:r:G alpha (12/13) signalling events", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-SSC-210990:r:PECAM1 interactions", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-5673000:r:RAF activation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-5673000:r:RAF activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-977443:r:GABA receptor activation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-XTR-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-XTR-9013026:r:RHOB GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-418594:r:G alpha (i) signalling events", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-CEL-9748787:r:Azathioprine ADME", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-RNO-177929:r:Signaling by EGFR", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-XTR-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-112399:r:IRS-mediated signalling", "R-HSA-9706369:r:Negative regulation of FLT3", "R-BTA-180292:r:GAB1 signalosome", "R-HSA-3000170:r:Syndecan interactions", "R-XTR-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-5621480:r:Dectin-2 family", "R-XTR-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-XTR-5654695:r:PI-3K cascade:FGFR2", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-BTA-9706369:r:Negative regulation of FLT3", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-XTR-74751:r:Insulin receptor signalling cascade", "R-HSA-373753:r:Nephrin family interactions", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-XTR-109704:r:PI3K Cascade", "R-DME-437239:r:Recycling pathway of L1", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-354192:r:Integrin signaling", "R-DME-3371378:r:Regulation by c-FLIP", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-8853659:r:RET signaling", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-XTR-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-109704:r:PI3K Cascade", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9842663:r:Signaling by LTK", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-9748787:r:Azathioprine ADME", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-525793:r:Myogenesis", "R-MMU-389948:r:Co-inhibition by PD-1", "R-DME-180292:r:GAB1 signalosome", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-9645135:r:STAT5 Activation", "R-CEL-6794361:r:Neurexins and neuroligins", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-GGA-389356:r:Co-stimulation by CD28", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-182971:r:EGFR downregulation", "R-HSA-8866376:r:Reelin signalling pathway", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-GGA-9013026:r:RHOB GTPase cycle", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-373753:r:Nephrin family interactions", "R-RNO-1433559:r:Regulation of KIT signaling", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-112412:r:SOS-mediated signalling", "R-XTR-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-SSC-389356:r:Co-stimulation by CD28", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DRE-430116:r:GP1b-IX-V activation signalling", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-MMU-193648:r:NRAGE signals death through JNK", "R-XTR-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-182971:r:EGFR downregulation", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-9694548:r:Maturation of spike protein", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-112412:r:SOS-mediated signalling", "R-XTR-1295596:r:Spry regulation of FGF signaling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-193648:r:NRAGE signals death through JNK", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-109704:r:PI3K Cascade", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-6807004:r:Negative regulation of MET activity", "R-SPO-9033241:r:Peroxisomal protein import", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-BTA-109704:r:PI3K Cascade", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-201556:r:Signaling by ALK", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-74749:r:Signal attenuation", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-422356:r:Regulation of insulin secretion", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-9013106:r:RHOC GTPase cycle", "R-CEL-373753:r:Nephrin family interactions", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-CEL-912631:r:Regulation of signaling by CBL", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SSC-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1433559:r:Regulation of KIT signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-XTR-180336:r:SHC1 events in EGFR signaling", "R-RNO-201556:r:Signaling by ALK", "R-BTA-9013407:r:RHOH GTPase cycle", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-BTA-912631:r:Regulation of signaling by CBL", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-XTR-5654720:r:PI-3K cascade:FGFR4", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-SPO-9013424:r:RHOV GTPase cycle", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-BTA-9766229:r:Degradation of CDH1", "R-RNO-977443:r:GABA receptor activation", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-XTR-5654710:r:PI-3K cascade:FGFR3", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-SSC-399956:r:CRMPs in Sema3A signaling", "R-MMU-202433:r:Generation of second messenger molecules", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-9013408:r:RHOG GTPase cycle", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-DRE-8853659:r:RET signaling", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DRE-416476:r:G alpha (q) signalling events", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013026:r:RHOB GTPase cycle", "R-XTR-6807004:r:Negative regulation of MET activity", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-XTR-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-XTR-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-210990:r:PECAM1 interactions", "R-SSC-912631:r:Regulation of signaling by CBL", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DRE-9035034:r:RHOF GTPase cycle", "R-DRE-1227986:r:Signaling by ERBB2", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-202433:r:Generation of second messenger molecules", "R-SSC-373753:r:Nephrin family interactions", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-RNO-354192:r:Integrin signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-MMU-5621480:r:Dectin-2 family", "R-GGA-912631:r:Regulation of signaling by CBL", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-9013424:r:RHOV GTPase cycle", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-74749:r:Signal attenuation", "R-BTA-418885:r:DCC mediated attractive signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-SSC-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-DME-186763:r:Downstream signal transduction", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-XTR-912631:r:Regulation of signaling by CBL", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-191650:r:Regulation of gap junction activity", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-9033241:r:Peroxisomal protein import", "R-RNO-198203:r:PI3K/AKT activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DRE-69231:r:Cyclin D associated events in G1", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-BTA-112399:r:IRS-mediated signalling", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-XTR-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-SCE-354192:r:Integrin signaling", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-XTR-9027284:r:Erythropoietin activates RAS", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-GGA-3928663:r:EPHA-mediated growth cone collapse", "R-XTR-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-XTR-9607240:r:FLT3 Signaling", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CEL-202433:r:Generation of second messenger molecules", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-XTR-8865999:r:MET activates PTPN11", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-SSC-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-9766229:r:Degradation of CDH1", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DME-9013148:r:CDC42 GTPase cycle", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-SCE-9033241:r:Peroxisomal protein import", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DRE-5621480:r:Dectin-2 family", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-2029481:r:FCGR activation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-1433559:r:Regulation of KIT signaling", "R-XTR-5654704:r:SHC-mediated cascade:FGFR3", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9031628:r:NGF-stimulated transcription", "R-BTA-2424491:r:DAP12 signaling", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-SSC-1227986:r:Signaling by ERBB2", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-GGA-193648:r:NRAGE signals death through JNK", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-9696270:r:RND2 GTPase cycle", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DME-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-167044:r:Signalling to RAS", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-9013420:r:RHOU GTPase cycle", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-8941237:r:Invadopodia formation", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-RNO-112399:r:IRS-mediated signalling", "R-XTR-179812:r:GRB2 events in EGFR signaling", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-GGA-9013409:r:RHOJ GTPase cycle", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-XTR-2424491:r:DAP12 signaling", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-XTR-9842663:r:Signaling by LTK", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8853659:r:RET signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-9696273:r:RND1 GTPase cycle", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DRE-177929:r:Signaling by EGFR", "R-HSA-9620244:r:Long-term potentiation", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-XTR-8851907:r:MET activates PI3K/AKT signaling", "R-XTR-167044:r:Signalling to RAS", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-69231:r:Cyclin D associated events in G1", "R-XTR-2871796:r:FCERI mediated MAPK activation", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-422356:r:Regulation of insulin secretion", "R-BTA-389356:r:Co-stimulation by CD28", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-8941237:r:Invadopodia formation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-171007:r:p38MAPK events", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-GGA-210990:r:PECAM1 interactions", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-180292:r:GAB1 signalosome", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-112399:r:IRS-mediated signalling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-373753:r:Nephrin family interactions", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-912631:r:Regulation of signaling by CBL", "R-HSA-420029:r:Tight junction interactions", "R-XTR-112412:r:SOS-mediated signalling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SSC-8866376:r:Reelin signalling pathway", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-5682910:r:LGI-ADAM interactions", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-8851805:r:MET activates RAS signaling", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-170984:r:ARMS-mediated activation", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-XTR-180292:r:GAB1 signalosome", "R-BTA-430116:r:GP1b-IX-V activation signalling", "R-HSA-191650:r:Regulation of gap junction activity", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-XTR-210993:r:Tie2 Signaling", "R-MMU-191650:r:Regulation of gap junction activity", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-167044:r:Signalling to RAS", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DME-69416:r:Dimerization of procaspase-8", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-XTR-8980692:r:RHOA GTPase cycle", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-DRE-9013420:r:RHOU GTPase cycle", "R-GGA-8980692:r:RHOA GTPase cycle", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-MMU-5689901:r:Metalloprotease DUBs", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-DME-912631:r:Regulation of signaling by CBL", "R-HSA-2029481:r:FCGR activation", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-210993:r:Tie2 Signaling", "R-BTA-9013409:r:RHOJ GTPase cycle", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-170968:r:Frs2-mediated activation", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-8865999:r:MET activates PTPN11", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-RNO-9748787:r:Azathioprine ADME", "R-DME-5673000:r:RAF activation", "R-CEL-525793:r:Myogenesis", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-XTR-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-8941237:r:Invadopodia formation", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-354192:r:Integrin signaling", "R-RNO-6794361:r:Neurexins and neuroligins", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-912631:r:Regulation of signaling by CBL", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-186763:r:Downstream signal transduction", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-GGA-186763:r:Downstream signal transduction", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-BTA-6807004:r:Negative regulation of MET activity", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-8866376:r:Reelin signalling pathway", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-BTA-5621480:r:Dectin-2 family", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-9013420:r:RHOU GTPase cycle", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-8853659:r:RET signaling", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-167044:r:Signalling to RAS", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-5673000:r:RAF activation", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-182971:r:EGFR downregulation", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-XTR-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-BTA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-SSC-2029481:r:FCGR activation", "R-MMU-3928664:r:Ephrin signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-BTA-3928664:r:Ephrin signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-8874081:r:MET activates PTK2 signaling", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-8875656:r:MET receptor recycling", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-XTR-1257604:r:PIP3 activates AKT signaling", "R-BTA-9013424:r:RHOV GTPase cycle", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-RNO-8866376:r:Reelin signalling pathway", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-9927353:r:Co-inhibition by BTLA", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-SCE-9013420:r:RHOU GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9748787:r:Azathioprine ADME", "R-BTA-5576893:r:Phase 2 - plateau phase", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-CEL-177929:r:Signaling by EGFR", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-432142:r:Platelet sensitization by LDL", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DRE-210990:r:PECAM1 interactions", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-SCE-392517:r:Rap1 signalling", "R-DME-5625900:r:RHO GTPases activate CIT", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-418885:r:DCC mediated attractive signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-XTR-8875656:r:MET receptor recycling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-354192:r:Integrin signaling", "R-XTR-8851805:r:MET activates RAS signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-XTR-9013424:r:RHOV GTPase cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-GGA-432142:r:Platelet sensitization by LDL", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-389356:r:Co-stimulation by CD28", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-1236394:r:Signaling by ERBB4", "R-BTA-1433559:r:Regulation of KIT signaling", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-422356:r:Regulation of insulin secretion", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-DRE-1295596:r:Spry regulation of FGF signaling", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SSC-9766229:r:Degradation of CDH1", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-RNO-2028269:r:Signaling by Hippo", "R-BTA-1227986:r:Signaling by ERBB2", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-201556:r:Signaling by ALK", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-XTR-1433557:r:Signaling by SCF-KIT", "R-CEL-182971:r:EGFR downregulation", "R-RNO-416476:r:G alpha (q) signalling events", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-XTR-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-9607240:r:FLT3 Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-186763:r:Downstream signal transduction", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-389356:r:Co-stimulation by CD28", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-XTR-74749:r:Signal attenuation", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-1227986:r:Signaling by ERBB2", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-XTR-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-5218900:r:CASP8 activity is inhibited", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-3928664:r:Ephrin signaling", "R-DME-74749:r:Signal attenuation", "R-XTR-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-9696264:r:RND3 GTPase cycle", "R-RNO-389948:r:Co-inhibition by PD-1", "R-DME-6794361:r:Neurexins and neuroligins", "R-BTA-210993:r:Tie2 Signaling", "R-DRE-193648:r:NRAGE signals death through JNK", "R-XTR-5654689:r:PI-3K cascade:FGFR1", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-8866376:r:Reelin signalling pathway", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-BTA-8853659:r:RET signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-XTR-182971:r:EGFR downregulation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", 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"R-HSA-9664565", "R-DME-438066", "R-HSA-5655302", "R-MMU-420029", "R-MMU-9907900", "R-HSA-9665244", "R-CEL-4641258", "R-HSA-9665686", "R-DME-8980692", "R-RNO-8853659", "R-MMU-166016", "R-MMU-8849932", "R-MMU-438066", "R-MMU-8853659", "R-MMU-5578775", "R-SSC-199220", "R-XTR-4641258", "R-MMU-5627083", "R-RNO-420029", "R-MMU-196780", "R-HSA-381033", "R-HSA-9013404", "R-MMU-264642", "R-HSA-9013149", "R-HSA-1169091", "R-HSA-8980692", "R-CFA-9013106", "R-HSA-9620244", "R-MMU-9913351", "R-MMU-2871837", "R-RNO-264642", "R-HSA-8948751", "R-RNO-181429", "R-RNO-8849932", "R-DME-5625900", "R-RNO-201688", "R-HSA-449836", "R-HSA-6803544", "R-MMU-8856825", "R-HSA-5368598", "R-RNO-418990", "R-DME-4641258", "R-DME-350368", "R-MMU-201688", "R-HSA-9619665", "R-HSA-416476", "R-MMU-8874211", "R-CEL-9013149", "R-HSA-9665245", "R-MMU-5213460", "R-BTA-212676", "R-HSA-6802946", "R-XTR-9696264", "R-XTR-9013423", "R-HSA-5578775", "R-RNO-9013106", "R-MMU-936837", "R-BTA-1655829", "R-HSA-9918481", "R-HSA-5607764", "R-MMU-5666185", "R-MMU-416993", "R-DRE-199220", "R-HSA-193648", "R-HSA-201688", "R-RNO-4608870", "R-DRE-9013408", "R-HSA-9013420", "R-CEL-9913351", "R-RNO-6807878", "R-HSA-5627083", "R-HSA-4086400", "R-MMU-6794361", "R-HSA-9662361", "R-HSA-6807878", "R-HSA-190373", "R-DME-9837999", "R-MMU-181429", "R-XTR-9035034", "R-DME-212676", "R-RNO-204005", "R-SSC-425397", "R-HSA-1236394", "R-MMU-418990", "R-BTA-9013408", "R-HSA-5213460", "R-RNO-5625900", "R-DME-8849932", "R-HSA-418594", "R-SCE-9907900", "R-DRE-8853659", "R-HSA-9703465", "R-MMU-9013026", "R-XTR-438066", "R-MMU-983168", "R-HSA-9022699", "R-RNO-5675482", "R-BTA-5610787", "R-MMU-9696270", "R-RNO-888590", "R-CFA-193648", "R-HSA-2028269", "R-HSA-9696273", "R-BTA-425397", "R-HSA-5675221"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-2028269:r:Signaling by Hippo", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-8874211:r:CREB3 factors activate genes", "R-HSA-420029:r:Tight junction interactions", "R-HSA-8951664:r:Neddylation", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-418990:r:Adherens junctions interactions", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-XTR-5610787:r:Hedgehog 'off' state", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-RNO-416476:r:G alpha (q) signalling events", "R-CEL-182971:r:EGFR downregulation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-BTA-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-9035034:r:RHOF GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-RNO-5682910:r:LGI-ADAM interactions", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-4086400:r:PCP/CE pathway", "R-MMU-392517:r:Rap1 signalling", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-MMU-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-4641258:r:Degradation of DVL", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-XTR-4086400:r:PCP/CE pathway", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-193648:r:NRAGE signals death through JNK", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-392517:r:Rap1 signalling", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-GGA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-191650:r:Regulation of gap junction activity", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-XTR-9013026:r:RHOB GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-MMU-191650:r:Regulation of gap junction activity", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-DME-2028269:r:Signaling by Hippo", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-HSA-9907900:r:Proteasome assembly", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-6803544:r:Ion influx/efflux at host-pathogen interface", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-RNO-9839397:r:TGFBR3 regulates FGF2 signaling", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-MMU-1227986:r:Signaling by ERBB2", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-RNO-3928664:r:Ephrin signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-XTR-8980692:r:RHOA GTPase cycle", "R-CEL-201688:r:WNT mediated activation of DVL", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-6794361:r:Neurexins and neuroligins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-191650:r:Regulation of gap junction activity", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-SSC-6803544:r:Ion influx/efflux at host-pathogen interface", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-8853659:r:RET signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-447043:r:Neurofascin interactions", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-CEL-4086400:r:PCP/CE pathway", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-BTA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-SPO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-DRE-196780:r:Biotin transport and metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6794361:r:Neurexins and neuroligins", "R-XTR-2028269:r:Signaling by Hippo", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-SSC-196780:r:Biotin transport and metabolism", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-9907900:r:Proteasome assembly", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-CEL-6794361:r:Neurexins and neuroligins", "R-MMU-2028269:r:Signaling by Hippo", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-RNO-5578775:r:Ion homeostasis", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-201688:r:WNT mediated activation of DVL", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-CEL-2028269:r:Signaling by Hippo", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-202424:r:Downstream TCR signaling", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-RNO-5610787:r:Hedgehog 'off' state", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-SSC-936837:r:Ion transport by P-type ATPases", "R-DME-9013148:r:CDC42 GTPase cycle", "R-DRE-5610787:r:Hedgehog 'off' state", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-DME-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-8942233:r:Intestinal infectious diseases", "R-DME-5610787:r:Hedgehog 'off' state", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-447038:r:NrCAM interactions", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-4641258:r:Degradation of DVL", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-182971:r:EGFR downregulation", "R-CFA-8980692:r:RHOA GTPase cycle", "R-MMU-4086400:r:PCP/CE pathway", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-BTA-196780:r:Biotin transport and metabolism", "R-XTR-9013408:r:RHOG GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-BTA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-196780:r:Biotin transport and metabolism", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-SCE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-8874211:r:CREB3 factors activate genes", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-9907900:r:Proteasome assembly", "R-DRE-9696264:r:RND3 GTPase cycle", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-447043:r:Neurofascin interactions", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-XTR-201688:r:WNT mediated activation of DVL", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-DME-418594:r:G alpha (i) signalling events", "R-MMU-447043:r:Neurofascin interactions", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-HSA-9634285:r:Constitutive 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adhesion proteins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DME-4086400:r:PCP/CE pathway", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-9035034:r:RHOF GTPase cycle", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-9035034:r:RHOF GTPase cycle", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-9839397:r:TGFBR3 regulates FGF2 signaling", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-MMU-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-420029:r:Tight junction interactions", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-CEL-4641258:r:Degradation of DVL", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DME-8980692:r:RHOA GTPase cycle", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-8853659:r:RET signaling", "R-MMU-5578775:r:Ion homeostasis", "R-SSC-199220:r:Vitamin B5 (pantothenate) metabolism", "R-XTR-4641258:r:Degradation of DVL", "R-MMU-5627083:r:RHO GTPases regulate CFTR trafficking", "R-RNO-420029:r:Tight junction interactions", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-HSA-9620244:r:Long-term potentiation", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-DME-5625900:r:RHO GTPases activate CIT", "R-RNO-201688:r:WNT mediated activation of DVL", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-RNO-418990:r:Adherens junctions interactions", "R-DME-4641258:r:Degradation of DVL", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-MMU-201688:r:WNT mediated activation of DVL", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-8874211:r:CREB3 factors activate genes", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-XTR-9696264:r:RND3 GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-BTA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DRE-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-201688:r:WNT mediated activation of DVL", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-HSA-4086400:r:PCP/CE pathway", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-XTR-9035034:r:RHOF GTPase cycle", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-SSC-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-HSA-1236394:r:Signaling by ERBB4", "R-MMU-418990:r:Adherens junctions interactions", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-418594:r:G alpha (i) signalling events", "R-SCE-9907900:r:Proteasome assembly", "R-DRE-8853659:r:RET signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-MMU-9013026:r:RHOB GTPase cycle", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-BTA-5610787:r:Hedgehog 'off' state", "R-MMU-9696270:r:RND2 GTPase cycle", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-CFA-193648:r:NRAGE signals death through JNK", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-9696273:r:RND1 GTPase cycle", "R-BTA-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Homologous_superfamily"}, "IPR036036": {"description": "SOCS box-like domain superfamily", "go_ids": ["GO:0035556"], "go_terms": ["GO:0035556:intracellular signal transduction:P"], "name": "SOCS_box-like_dom_sf", "pathway_ids": ["R-BTA-983168", "R-RNO-877300", "R-DME-983168", "R-BTA-8951664", "R-GGA-983168", "R-RNO-6785807", "R-HSA-1059683", "R-HSA-8873719", "R-HSA-8951664", "R-DME-8951664", "R-DRE-8951664", "R-RNO-1059683", "R-GGA-8951664", "R-SSC-8951664", "R-RNO-877312", "R-DRE-983168", "R-MMU-8951664", "R-GGA-877300", "R-SSC-9706369", "R-HSA-8849474", "R-HSA-877312", "R-BTA-1059683", "R-HSA-912694", "R-BTA-877300", "R-MMU-909733", "R-BTA-9706369", "R-HSA-1266695", "R-HSA-2586552", "R-MMU-877312", "R-BTA-877312", "R-HSA-9706369", "R-BTA-8849474", "R-BTA-9705462", "R-HSA-166058", "R-GGA-1059683", "R-MMU-8849474", "R-RNO-8849474", "R-MMU-9706369", "R-RNO-9705462", "R-GGA-877312", "R-HSA-983168", "R-HSA-6785807", "R-XTR-8951664", "R-MMU-877300", "R-MMU-9705462", "R-HSA-982772", "R-MMU-8873719", "R-HSA-1433559", "R-MMU-1059683", "R-GGA-909733", "R-HSA-909733", "R-XTR-983168", "R-RNO-909733", "R-HSA-9705462", "R-HSA-877300", "R-RNO-8951664", "R-BTA-909733", "R-MMU-983168", "R-HSA-9674555", "R-RNO-983168", "R-MMU-6785807", "R-HSA-8939242"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-877300:r:Interferon gamma signaling", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8951664:r:Neddylation", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-8873719:r:RAB geranylgeranylation", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-GGA-8951664:r:Neddylation", "R-SSC-8951664:r:Neddylation", "R-RNO-877312:r:Regulation of IFNG signaling", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-GGA-877300:r:Interferon gamma signaling", "R-SSC-9706369:r:Negative regulation of FLT3", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-HSA-877312:r:Regulation of IFNG signaling", "R-BTA-1059683:r:Interleukin-6 signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-BTA-877300:r:Interferon gamma signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-BTA-9706369:r:Negative regulation of FLT3", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-2586552:r:Signaling by Leptin", "R-MMU-877312:r:Regulation of IFNG signaling", "R-BTA-877312:r:Regulation of IFNG signaling", "R-HSA-9706369:r:Negative regulation of FLT3", "R-BTA-8849474:r:PTK6 Activates STAT3", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-GGA-1059683:r:Interleukin-6 signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-8849474:r:PTK6 Activates STAT3", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-877312:r:Regulation of IFNG signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-XTR-8951664:r:Neddylation", "R-MMU-877300:r:Interferon gamma signaling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-8873719:r:RAB geranylgeranylation", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-RNO-8951664:r:Neddylation", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "type": "Homologous_superfamily"}, "IPR036038": {"description": "Aminotransferase-like, PLP-dependent enzymes", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Aminotransferase-like", "pathway_ids": ["R-BTA-70895", "R-SPO-70895", "R-MMU-70895", "R-CEL-70895", "R-DDI-70895", "R-HSA-70895", "R-SCE-70895", "R-RNO-70895"], "pathways": ["R-BTA-70895:r:Branched-chain amino acid catabolism", "R-SPO-70895:r:Branched-chain amino acid catabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-SCE-70895:r:Branched-chain amino acid catabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Homologous_superfamily"}, "IPR036039": {"description": "Influenza virus matrix protein M1", "go_ids": ["GO:0003723", "GO:0005198"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005198:structural molecule activity:F"], "name": "Flu_matrix_M1", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168288", "R-HSA-168275", "R-HSA-168316", "R-HSA-168298", "R-HSA-168330", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168316:r:Assembly of Viral Components at the Budding Site", "R-HSA-168298:r:Release", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Homologous_superfamily"}, "IPR036041": {"description": "Ribosome-inactivating protein superfamily", "go_ids": ["GO:0017148", "GO:0030598"], "go_terms": ["GO:0017148:negative regulation of translation:P", "GO:0030598:rRNA N-glycosylase activity:F"], "name": "Ribosome-inact_prot_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036043": {"description": "Phosphoglycerate kinase superfamily", "go_ids": ["GO:0004618", "GO:0006096"], "go_terms": ["GO:0004618:phosphoglycerate kinase activity:F", "GO:0006096:glycolytic process:P"], "name": "Phosphoglycerate_kinase_sf", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-6886", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-MMU-70171", "R-RNO-70263", "R-SCE-70171", "R-SSC-70263", "R-BTA-70171", "R-DME-70171", "R-PFA-70263", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-DME-70263", "R-PFA-70171", "R-DDI-70263", "R-RNO-70171", "R-GGA-352882", "R-SSC-70171", "R-HSA-70263", "R-CEL-70263", "R-BTA-70263", "R-SCE-70263", "R-HSA-9636667", "R-HSA-70171", "R-SPO-70171", "R-SPO-70263"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-RNO-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-SSC-70263:r:Gluconeogenesis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-PFA-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-PFA-70171:r:Glycolysis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-SSC-70171:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SPO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR036045": {"description": "Sec1-like superfamily", "go_ids": [], "go_terms": [], "name": "Sec1-like_sf", "pathway_ids": ["R-MMU-204005", "R-DDI-114516", "R-MMU-6811438", "R-CEL-181430", "R-MMU-181430", "R-CEL-114516", "R-SCE-204005", "R-SCE-114608", "R-DDI-114608", "R-CEL-888590", "R-RNO-212676", "R-SCE-8980692", "R-RNO-983231", "R-CEL-264642", "R-HSA-210500", "R-MMU-449836", "R-BTA-181430", "R-HSA-181430", "R-DDI-204005", "R-DME-210500", "R-DME-8980692", "R-DME-114608", "R-RNO-6811438", "R-HSA-983231", "R-CEL-114608", "R-HSA-264642", "R-BTA-888590", "R-CEL-212676", "R-DDI-6811438", "R-MMU-264642", "R-SPO-8980692", "R-HSA-204005", "R-HSA-8980692", "R-DME-181430", "R-RNO-264642", "R-HSA-1445148", "R-RNO-181429", "R-SCE-983231", "R-HSA-212676", "R-MMU-114608", "R-DME-204005", "R-HSA-114516", "R-HSA-449836", "R-BTA-210500", "R-HSA-6811438", "R-MMU-8980692", "R-RNO-8980692", "R-CEL-210500", "R-MMU-983231", "R-DME-264642", "R-SPO-114608", "R-HSA-6794361", "R-RNO-114608", "R-DME-888590", "R-DME-449836", "R-HSA-181429", "R-SPO-114516", "R-HSA-114608", "R-HSA-9754560", "R-HSA-9636383", "R-BTA-212676", "R-CEL-181429", "R-DME-181429", "R-BTA-264642", "R-DDI-449836", "R-MMU-212676", "R-MMU-114516", "R-SCE-114516", "R-MMU-888590", "R-RNO-210500", "R-RNO-181430", "R-MMU-210500", "R-SPO-204005", "R-MMU-181429", "R-CEL-449836", "R-DME-212676", "R-RNO-204005", "R-HSA-888590", "R-DME-114516", "R-BTA-181429", "R-RNO-888590", "R-RNO-449836", "R-HSA-422356"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-MMU-6811438:r:Intra-Golgi traffic", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-114608:r:Platelet degranulation", "R-DDI-114608:r:Platelet degranulation", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-449836:r:Other interleukin signaling", "R-BTA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-114608:r:Platelet degranulation", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-114608:r:Platelet degranulation", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DDI-6811438:r:Intra-Golgi traffic", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-114608:r:Platelet degranulation", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-HSA-449836:r:Other interleukin signaling", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SPO-114608:r:Platelet degranulation", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-114608:r:Platelet degranulation", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-449836:r:Other interleukin signaling", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DDI-449836:r:Other interleukin signaling", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-449836:r:Other interleukin signaling", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-114516:r:Disinhibition of SNARE formation", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Homologous_superfamily"}, "IPR036046": {"description": "Acylphosphatase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Acylphosphatase-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036047": {"description": "F-box-like domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "F-box-like_dom_sf", "pathway_ids": ["R-BTA-983168", "R-DDI-354192", "R-HSA-174178", "R-HSA-9020702", "R-HSA-9604323", "R-CFA-8951664", "R-MMU-5607764", "R-SPO-9907900", "R-HSA-8951664", "R-HSA-5689880", "R-HSA-9932298", "R-DRE-8951664", "R-HSA-5676590", "R-DRE-174113", "R-HSA-69231", "R-MMU-2565942", "R-DDI-8951664", "R-MMU-8951664", "R-MMU-5689880", "R-HSA-5684264", "R-MMU-68881", "R-HSA-8854050", "R-HSA-174113", "R-DDI-9013423", "R-HSA-5610783", "R-HSA-2122947", "R-HSA-9708530", "R-MMU-5684264", "R-DDI-6798695", "R-DDI-193648", "R-HSA-5607761", "R-HSA-1170546", "R-MMU-174113", "R-HSA-9687136", "R-SSC-983168", "R-DDI-5673001", "R-DRE-68881", "R-MMU-9708530", "R-HSA-1169091", "R-MMU-2871837", "R-HSA-2644607", "R-BTA-917937", "R-RNO-8951664", "R-DRE-176417", "R-HSA-180534", "R-SPO-8951664", "R-HSA-2644606", "R-RNO-983168", "R-CFA-983168", "R-MMU-69231", "R-BTA-8951664", "R-HSA-68949", "R-HSA-187577", "R-HSA-5610785", "R-MMU-187577", "R-HSA-3769402", "R-MMU-68949", "R-SSC-8951664", "R-MMU-174178", "R-CEL-983168", "R-DDI-9013149", "R-MMU-69601", "R-DRE-983168", "R-HSA-2565942", "R-HSA-2871837", "R-MMU-917937", "R-DDI-381676", "R-HSA-9615017", "R-DRE-917937", "R-MMU-8854050", "R-SPO-983168", "R-SCE-983168", "R-DRE-176408", "R-HSA-9762114", "R-HSA-5607764", "R-MMU-202424", "R-HSA-195253", "R-MMU-176408", "R-HSA-5610780", "R-DDI-171007", "R-HSA-390471", "R-MMU-176417", "R-DDI-392517", "R-HSA-2894862", "R-MMU-1169091", "R-HSA-69601", "R-HSA-983168", "R-XTR-8951664", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-8939902", "R-DDI-983168", "R-HSA-9929356", "R-XTR-983168", "R-MMU-8939902", "R-HSA-917937", "R-MMU-983168", "R-HSA-202424", "R-DDI-1169092", "R-CEL-8951664", "R-DRE-8854050"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-354192:r:Integrin signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-CFA-8951664:r:Neddylation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-9907900:r:Proteasome assembly", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DRE-8951664:r:Neddylation", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-68881:r:Mitotic Metaphase/Anaphase Transition", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-193648:r:NRAGE signals death through JNK", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-DRE-68881:r:Mitotic Metaphase/Anaphase Transition", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-BTA-917937:r:Iron uptake and transport", "R-RNO-8951664:r:Neddylation", "R-DRE-176417:r:Phosphorylation of Emi1", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-BTA-8951664:r:Neddylation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-SSC-8951664:r:Neddylation", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-917937:r:Iron uptake and transport", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-DRE-917937:r:Iron uptake and transport", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-171007:r:p38MAPK events", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-176417:r:Phosphorylation of Emi1", "R-DDI-392517:r:Rap1 signalling", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-8951664:r:Neddylation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-917937:r:Iron uptake and transport", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-1169092:r:Activation of RAS in B cells", "R-CEL-8951664:r:Neddylation", "R-DRE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "type": "Homologous_superfamily"}, "IPR036048": {"description": "Chemokine interleukin-8-like superfamily", "go_ids": ["GO:0005576", "GO:0006955", "GO:0008009"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0006955:immune response:P", "GO:0008009:chemokine activity:F"], "name": "Interleukin_8-like_sf", "pathway_ids": ["R-HSA-6798695", "R-MMU-416476", "R-SSC-6798695", "R-MMU-444473", "R-HSA-9942503", "R-SSC-380108", "R-GGA-418594", "R-HSA-375276", "R-HSA-8936459", "R-HSA-1251985", "R-SSC-114608", "R-MMU-380108", "R-RNO-444473", "R-RNO-140875", "R-BTA-6798695", "R-HSA-2559582", "R-HSA-416476", "R-CFA-380108", "R-GGA-375276", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-BTA-418594", "R-HSA-380994", "R-RNO-202733", "R-MMU-202733", "R-HSA-444473", "R-RNO-416476", "R-HSA-6783783", "R-HSA-9018519", "R-HSA-9610379", "R-HSA-376176", "R-GGA-114608", "R-HSA-6785807", "R-HSA-140875", "R-MMU-140875", "R-CFA-375276", "R-SSC-375276", "R-HSA-418594", "R-MMU-376176", "R-HSA-380108", "R-HSA-9818026", "R-BTA-380108", "R-CFA-418594", "R-GGA-380108", "R-SSC-418594", "R-MMU-6798695", "R-RNO-380108", "R-HSA-202733", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-SSC-380108:r:Chemokine receptors bind chemokines", "R-GGA-418594:r:G alpha (i) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-114608:r:Platelet degranulation", "R-MMU-380108:r:Chemokine receptors bind chemokines", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-416476:r:G alpha (q) signalling events", "R-CFA-380108:r:Chemokine receptors bind chemokines", "R-GGA-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-376176:r:Signaling by ROBO receptors", "R-GGA-114608:r:Platelet degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-CFA-375276:r:Peptide ligand-binding receptors", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-380108:r:Chemokine receptors bind chemokines", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-BTA-380108:r:Chemokine receptors bind chemokines", "R-CFA-418594:r:G alpha (i) signalling events", "R-GGA-380108:r:Chemokine receptors bind chemokines", "R-SSC-418594:r:G alpha (i) signalling events", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-380108:r:Chemokine receptors bind chemokines", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036049": {"description": "Large ribosomal subunit protein uL29 superfamily", "go_ids": ["GO:0003735", "GO:0005840", "GO:0006412"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C", "GO:0006412:translation:P"], "name": "Ribosomal_uL29_sf", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-DRE-9954709", "R-RNO-1799339", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-BTA-156827", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-DRE-9954714", "R-SCE-975956", "R-CEL-1799339", "R-SSC-9954714", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-SSC-1799339", "R-DRE-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-DDI-156827", "R-RNO-9954709", "R-SSC-72689", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DRE-975956", "R-BTA-9954716", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-HSA-156902", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-SSC-6791226", "R-BTA-9954709", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SSC-9954716", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036050": {"description": "E2 regulatory, transactivation domain", "go_ids": ["GO:0006275", "GO:0006355", "GO:0016032"], "go_terms": ["GO:0006275:regulation of DNA replication:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0016032:viral process:P"], "name": "Regulatory_protein_E2_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036051": {"description": "Krueppel-associated box domain superfamily", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "KRAB_dom_sf", "pathway_ids": ["R-MMU-9843940", "R-MMU-3214841", "R-MMU-212436", "R-MMU-77588", "R-MMU-73856", "R-HSA-73856", "R-RNO-3214841", "R-HSA-3214841", "R-HSA-6803204", "R-HSA-77588", "R-HSA-912446", "R-HSA-111367", "R-MMU-111367", "R-RNO-212436", "R-RNO-9843940", "R-HSA-9843940", "R-HSA-3899300", "R-HSA-212436", "R-BTA-212436"], "pathways": ["R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-212436:r:Generic Transcription Pathway", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-912446:r:Meiotic recombination", "R-HSA-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-RNO-212436:r:Generic Transcription Pathway", "R-RNO-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Homologous_superfamily"}, "IPR036052": {"description": "Tryptophan synthase beta chain-like, PALP domain superfamily", "go_ids": [], "go_terms": [], "name": "TrpB-like_PALP_sf", "pathway_ids": ["R-DDI-1614603", "R-DDI-977347", "R-MMU-977347", "R-CEL-1614603", "R-SPO-977347", "R-RNO-977347", "R-DDI-8849175", "R-MMU-8849175", "R-HSA-2408508", "R-HSA-1614603", "R-HSA-977347", "R-MTU-936721", "R-BTA-977347", "R-MMU-1614603", "R-HSA-8849175", "R-SCE-1614603", "R-MTU-936654", "R-SCE-8849175", "R-SCE-977347", "R-RNO-8849175", "R-RNO-1614603"], "pathways": ["R-DDI-1614603:r:Cysteine formation from homocysteine", "R-DDI-977347:r:Serine metabolism", "R-MMU-977347:r:Serine metabolism", "R-CEL-1614603:r:Cysteine formation from homocysteine", "R-SPO-977347:r:Serine metabolism", "R-RNO-977347:r:Serine metabolism", "R-DDI-8849175:r:Threonine catabolism", "R-MMU-8849175:r:Threonine catabolism", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-HSA-1614603:r:Cysteine formation from homocysteine", "R-HSA-977347:r:Serine metabolism", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine", "R-BTA-977347:r:Serine metabolism", "R-MMU-1614603:r:Cysteine formation from homocysteine", "R-HSA-8849175:r:Threonine catabolism", "R-SCE-1614603:r:Cysteine formation from homocysteine", "R-MTU-936654:r:Cysteine synthesis from O-phosphoserine", "R-SCE-8849175:r:Threonine catabolism", "R-SCE-977347:r:Serine metabolism", "R-RNO-8849175:r:Threonine catabolism", "R-RNO-1614603:r:Cysteine formation from homocysteine"], "type": "Homologous_superfamily"}, "IPR036053": {"description": "PABC (PABP) domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "PABP-dom", "pathway_ids": ["R-MMU-450408", "R-DDI-975956", "R-DME-156827", "R-BTA-975957", "R-DME-429947", "R-HSA-9010553", "R-HSA-9918487", "R-DME-72649", "R-SPO-975957", "R-HSA-156827", "R-MMU-72649", "R-HSA-975956", "R-HSA-9820865", "R-DME-450408", "R-SCE-975957", "R-MMU-429947", "R-BTA-429947", "R-HSA-450408", "R-RNO-450408", "R-MMU-975956", "R-RNO-975957", "R-DRE-156827", "R-SCE-156827", "R-DRE-975956", "R-SPO-975956", "R-DME-975956", "R-BTA-156827", "R-RNO-156827", "R-SPO-72649", "R-BTA-450408", "R-SCE-975956", "R-HSA-429947", "R-MMU-975957", "R-DRE-975957", "R-DRE-450408", "R-HSA-72649", "R-MMU-156827", "R-RNO-429947", "R-RNO-72649", "R-DRE-72649", "R-HSA-975957", "R-SCE-72649", "R-RNO-975956", "R-BTA-975956", "R-HSA-9820841", "R-DDI-450408", "R-SPO-156827", "R-DDI-975957", "R-BTA-72649", "R-DME-975957", "R-DDI-156827", "R-SPO-429947", "R-SCE-429947"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-429947:r:Deadenylation of mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-DME-72649:r:Translation initiation complex formation", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-429947:r:Deadenylation of mRNA", "R-BTA-429947:r:Deadenylation of mRNA", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72649:r:Translation initiation complex formation", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-429947:r:Deadenylation of mRNA", "R-RNO-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-72649:r:Translation initiation complex formation", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-429947:r:Deadenylation of mRNA", "R-SCE-429947:r:Deadenylation of mRNA"], "type": "Homologous_superfamily"}, "IPR036054": {"description": "BTG-like domain superfamily", "go_ids": [], "go_terms": [], "name": "BTG-like_sf", "pathway_ids": ["R-MMU-6804115", "R-DDI-6804115", "R-HSA-6804115", "R-HSA-9617828", "R-HSA-9820841", "R-RNO-6804115"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DDI-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Homologous_superfamily"}, "IPR036055": {"description": "LDL receptor-like superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "LDL_receptor-like_sf", "pathway_ids": ["R-MMU-8856828", "R-HSA-879415", "R-BTA-8964026", "R-MMU-8964046", "R-MMU-4641263", "R-HSA-9700645", "R-HSA-3000178", "R-HSA-8856828", "R-HSA-3560783", "R-RNO-8866376", "R-HSA-9918485", "R-HSA-2168880", "R-HSA-432142", "R-CEL-1566948", "R-RNO-8964026", "R-HSA-9856532", "R-HSA-3656237", "R-GGA-8866376", "R-MMU-8957275", "R-RNO-8964038", "R-HSA-9717301", "R-MMU-432142", "R-HSA-6806942", "R-RNO-977606", "R-MMU-975634", "R-BTA-8957275", "R-MMU-201556", "R-RNO-9758890", "R-CEL-2129379", "R-HSA-166665", "R-HSA-9678110", "R-MMU-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-3359485", "R-HSA-901042", "R-MMU-2168880", "R-RNO-8866427", "R-HSA-381426", "R-RNO-8964046", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-532668", "R-CEL-216083", "R-BTA-166665", "R-MMU-5578768", "R-HSA-9717264", "R-RNO-2168880", "R-RNO-5578768", "R-HSA-3000171", "R-HSA-1971475", "R-HSA-418555", "R-HSA-9694614", "R-HSA-3560801", "R-HSA-9820960", "R-RNO-5173214", "R-RNO-196791", "R-MMU-8866427", "R-MMU-9758890", "R-MMU-5173214", "R-MMU-4641262", "R-HSA-4420332", "R-BTA-9768727", "R-MMU-418555", "R-MMU-9851151", "R-CEL-2173789", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-201681", "R-HSA-9683686", "R-MMU-3772470", "R-HSA-6809371", "R-MMU-8856825", "R-HSA-3000157", "R-DRE-9842663", "R-CFA-9851151", "R-HSA-9694548", "R-HSA-977225", "R-HSA-9717316", "R-MMU-166665", "R-HSA-8964046", "R-HSA-5578768", "R-MMU-444821", "R-HSA-9717329", "R-CEL-1474228", "R-HSA-3656253", "R-CFA-201556", "R-HSA-196791", "R-MMU-8852405", "R-HSA-977606", "R-HSA-9725370", "R-MMU-8964038", "R-BTA-381426", "R-HSA-4641262", "R-HSA-2024096", "R-HSA-5340588", "R-RNO-8856828", "R-RNO-975634", "R-HSA-2022928", "R-HSA-9833110", "R-HSA-9717323", "R-HSA-9918481", "R-HSA-1442490", "R-BTA-8856828", "R-HSA-3772470", "R-HSA-8852405", "R-MMU-977606", "R-RNO-8856825", "R-HSA-9733458", "R-HSA-216083", "R-HSA-5083635", "R-HSA-5339717", "R-HSA-4641263", "R-HSA-8964026", "R-HSA-9913351", "R-MMU-8964026", "R-HSA-9717319", "R-HSA-444821", "R-HSA-9758890", "R-HSA-9851151", "R-BTA-8856825", "R-HSA-8866427", "R-GGA-8866427", "R-RNO-166665", "R-HSA-5173214", "R-BTA-8964038", "R-HSA-8856825", "R-MMU-8866376", "R-MMU-6806942", "R-CFA-444821", "R-HSA-9717326", "R-HSA-201556", "R-HSA-8957275", "R-HSA-8866376", "R-MMU-1442490", "R-RNO-444821", "R-HSA-8964038", "R-HSA-975634"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-BTA-8964026:r:Chylomicron clearance", "R-MMU-8964046:r:VLDL clearance", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-RNO-8866376:r:Reelin signalling pathway", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-432142:r:Platelet sensitization by LDL", "R-CEL-1566948:r:Elastic fibre formation", "R-RNO-8964026:r:Chylomicron clearance", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-GGA-8866376:r:Reelin signalling pathway", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-8964038:r:LDL clearance", "R-HSA-9717301:r:NVP-TAE684-resistant ALK mutants", "R-MMU-432142:r:Platelet sensitization by LDL", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-975634:r:Retinoid metabolism and transport", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-201556:r:Signaling by ALK", "R-RNO-9758890:r:Transport of RCbl within the body", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-9678110:r:Attachment and Entry", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-3359485:r:Defective CD320 causes MMATC", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8964046:r:VLDL clearance", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-166665:r:Terminal pathway of complement", "R-MMU-5578768:r:Physiological factors", "R-HSA-9717264:r:ASP-3026-resistant ALK mutants", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-RNO-5578768:r:Physiological factors", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-9758890:r:Transport of RCbl within the body", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-418555:r:G alpha (s) signalling events", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-9683686:r:Maturation of spike protein", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000157:r:Laminin interactions", "R-DRE-9842663:r:Signaling by LTK", "R-CFA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-9717316:r:alectinib-resistant ALK mutants", "R-MMU-166665:r:Terminal pathway of complement", "R-HSA-8964046:r:VLDL clearance", "R-HSA-5578768:r:Physiological factors", "R-MMU-444821:r:Relaxin receptors", "R-HSA-9717329:r:lorlatinib-resistant ALK mutants", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-CFA-201556:r:Signaling by ALK", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-8852405:r:Signaling by MST1", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-8964038:r:LDL clearance", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-2024096:r:HS-GAG degradation", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9717323:r:ceritinib-resistant ALK mutants", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-1442490:r:Collagen degradation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-8852405:r:Signaling by MST1", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8964026:r:Chylomicron clearance", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9717319:r:brigatinib-resistant ALK mutants", "R-HSA-444821:r:Relaxin receptors", "R-HSA-9758890:r:Transport of RCbl within the body", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-RNO-166665:r:Terminal pathway of complement", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8866376:r:Reelin signalling pathway", "R-MMU-6806942:r:MET Receptor Activation", "R-CFA-444821:r:Relaxin receptors", "R-HSA-9717326:r:crizotinib-resistant ALK mutants", "R-HSA-201556:r:Signaling by ALK", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-8866376:r:Reelin signalling pathway", "R-MMU-1442490:r:Collagen degradation", "R-RNO-444821:r:Relaxin receptors", "R-HSA-8964038:r:LDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Homologous_superfamily"}, "IPR036056": {"description": "Fibrinogen-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Fibrinogen-like_C", "pathway_ids": ["R-HSA-6798695", "R-HSA-1989781", "R-BTA-9762292", "R-HSA-5674135", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-BTA-5673001", "R-HSA-8963889", "R-RNO-140875", "R-BTA-6798695", "R-MMU-210993", "R-MMU-8957275", "R-HSA-2855086", "R-HSA-9841922", "R-MMU-3000178", "R-HSA-9649948", "R-MMU-381426", "R-HSA-6803157", "R-RNO-8963889", "R-HSA-166663", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-6802955", "R-HSA-381426", "R-RNO-3000178", "R-RNO-5686938", "R-HSA-447043", "R-HSA-166058", "R-RNO-210993", "R-HSA-6802948", "R-HSA-210993", "R-BTA-8963889", "R-MMU-5686938", "R-MMU-9762292", "R-SSC-8963889", "R-HSA-5673001", "R-RNO-381426", "R-RNO-2855086", "R-MMU-216083", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-1236974", "R-HSA-5603041", "R-HSA-372708", "R-MMU-354192", "R-RNO-6798695", "R-HSA-9656223", "R-MMU-114608", "R-SSC-9762292", "R-HSA-9029558", "R-MMU-5674135", "R-RNO-216083", "R-HSA-977225", "R-CFA-210993", "R-MMU-2855086", "R-RNO-9762292", "R-RNO-354194", "R-RNO-114608", "R-MMU-372708", "R-HSA-114608", "R-RNO-354192", "R-HSA-6802946", "R-RNO-8957275", "R-MMU-6803157", "R-RNO-5674135", "R-HSA-5686938", "R-BTA-2129379", "R-HSA-354192", "R-HSA-2129379", "R-HSA-216083", "R-HSA-3000170", "R-HSA-381340", "R-MMU-8963889", "R-HSA-354194", "R-MMU-354194", "R-HSA-140875", "R-MMU-140875", "R-HSA-166662", "R-BTA-210993", "R-HSA-5602498", "R-HSA-8957275", "R-BTA-2855086", "R-MMU-2129379"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1989781:r:PPARA activates gene expression", "R-BTA-9762292:r:Regulation of CDH11 function", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-210993:r:Tie2 Signaling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-166663:r:Initial triggering of complement", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-210993:r:Tie2 Signaling", "R-BTA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-9762292:r:Regulation of CDH11 function", "R-SSC-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-114608:r:Platelet degranulation", "R-SSC-9762292:r:Regulation of CDH11 function", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-977225:r:Amyloid fiber formation", "R-CFA-210993:r:Tie2 Signaling", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-RNO-9762292:r:Regulation of CDH11 function", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-114608:r:Platelet degranulation", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-RNO-354192:r:Integrin signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-6803157:r:Antimicrobial peptides", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-HSA-354192:r:Integrin signaling", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-166662:r:Lectin pathway of complement activation", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Homologous_superfamily"}, "IPR036058": {"description": "Kazal domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Kazal_dom_sf", "pathway_ids": ["R-CEL-1592389", "R-HSA-6798695", "R-MMU-163125", "R-MMU-2024096", "R-RNO-3000497", "R-HSA-3560783", "R-HSA-3000178", "R-RNO-1474228", "R-HSA-9918485", "R-HSA-3656237", "R-MMU-8957275", "R-RNO-2024096", "R-RNO-977606", "R-MMU-975634", "R-BTA-8957275", "R-MMU-189483", "R-RNO-9793528", "R-MMU-3000178", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-RNO-3000178", "R-RNO-189483", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-5619058", "R-SSC-2473224", "R-MMU-1592389", "R-HSA-3000171", "R-HSA-1971475", 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"R-HSA-1592389", "R-RNO-879518", "R-MMU-9793528", "R-RNO-9913351", "R-RNO-1971475", "R-RNO-2022928", "R-HSA-9793528", "R-HSA-8957275", "R-SSC-3000497", "R-HSA-159418", "R-MMU-2473224", "R-MMU-1971475", "R-MMU-159418", "R-HSA-975634"], "pathways": ["R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-2024096:r:HS-GAG degradation", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-2024096:r:HS-GAG degradation", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-975634:r:Retinoid metabolism and transport", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-189483:r:Heme degradation", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-MMU-3000178:r:ECM proteoglycans", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-189483:r:Heme degradation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-5619058:r:Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)", "R-SSC-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CEL-114608:r:Platelet degranulation", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-419037:r:NCAM1 interactions", "R-BTA-3000497:r:Scavenging by Class H Receptors", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-879518:r:Organic anion transport by SLCO transporters", "R-HSA-9754706:r:Atorvastatin ADME", "R-MMU-6809371:r:Formation of the cornified envelope", "R-MMU-9754706:r:Atorvastatin ADME", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-5619110:r:Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-879518:r:Organic anion transport by SLCO transporters", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-114608:r:Platelet degranulation", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-2473224:r:Antagonism of Activin by Follistatin", "R-BTA-879518:r:Organic anion transport by SLCO transporters", "R-RNO-114608:r:Platelet degranulation", "R-HSA-189483:r:Heme degradation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-RNO-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-9754706:r:Atorvastatin ADME", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2024096:r:HS-GAG degradation", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-MMU-201451:r:Signaling by BMP", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-201451:r:Signaling by BMP", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6809371:r:Formation of the cornified envelope", "R-HSA-5619095:r:Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)", "R-RNO-6809371:r:Formation of the cornified envelope", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-879518:r:Organic anion transport by SLCO transporters", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-3000497:r:Scavenging by Class H Receptors", "R-HSA-159418:r:Recycling of bile acids and salts", "R-MMU-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-159418:r:Recycling of bile acids and salts", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Homologous_superfamily"}, "IPR036059": {"description": "Metalloprotease TldD/PmbA superfamily", "go_ids": ["GO:0006508", "GO:0008237"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008237:metallopeptidase activity:F"], "name": "TldD/PmbA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036060": {"description": "Zinc finger, C2H2C-type superfamily", "go_ids": ["GO:0005634", "GO:0006355", "GO:0008270"], "go_terms": ["GO:0005634:nucleus:C", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0008270:zinc ion binding:F"], "name": "Znf_C2H2C_sf", "pathway_ids": ["R-MMU-3214847", "R-MMU-6804760", "R-HSA-3214847", "R-RNO-3214847", "R-HSA-6804760", "R-RNO-6804760"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation"], "type": "Homologous_superfamily"}, "IPR036061": {"description": "CheW-like domain superfamily", "go_ids": ["GO:0006935", "GO:0007165"], "go_terms": ["GO:0006935:chemotaxis:P", "GO:0007165:signal transduction:P"], "name": "CheW-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036062": {"description": "Photosystem I PsaJ, reaction centre subunit IX superfamily", "go_ids": ["GO:0009522", "GO:0015979"], "go_terms": ["GO:0009522:photosystem I:C", "GO:0015979:photosynthesis:P"], "name": "PSI_PsaJ_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036063": {"description": "Smr domain superfamily", "go_ids": [], "go_terms": [], "name": "Smr_dom_sf", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Homologous_superfamily"}, "IPR036065": {"description": "BolA-like superfamily", "go_ids": [], "go_terms": [], "name": "BolA-like_sf", "pathway_ids": ["R-HSA-8950505"], "pathways": ["R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "type": "Homologous_superfamily"}, "IPR036068": {"description": "Nicotinate phosphoribosyltransferase-like, C-terminal", "go_ids": ["GO:0009435"], "go_terms": ["GO:0009435:NAD+ biosynthetic process:P"], "name": "Nicotinate_pribotase-like_C", "pathway_ids": ["PWY-5381", "R-RNO-6798695", "R-DDI-6798695", "R-HSA-6798695", "R-MMU-196807", "R-DRE-6798695", "R-DME-196807", "R-DME-6798695", "R-DRE-196807", "R-SCE-196807", "R-CEL-6798695", "R-HSA-196807", "R-MMU-6798695", "R-CEL-196807", "R-DDI-196807", "R-HSA-1368108", "R-RNO-196807", "R-HSA-9768919", "R-SSC-196807"], "pathways": ["PWY-5381:t:NAD salvage (plants)", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-196807:r:Nicotinate metabolism", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-196807:r:Nicotinate metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-DRE-196807:r:Nicotinate metabolism", "R-SCE-196807:r:Nicotinate metabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-196807:r:Nicotinate metabolism", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-SSC-196807:r:Nicotinate metabolism"], "type": "Homologous_superfamily"}, "IPR036069": {"description": "DUF34/NIF3 superfamily", "go_ids": [], "go_terms": [], "name": "DUF34/NIF3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036070": {"description": "Nop domain superfamily", "go_ids": [], "go_terms": [], "name": "Nop_dom_sf", "pathway_ids": ["R-MMU-6791226", "R-SCE-4570464", "R-HSA-390471", "R-MMU-72163", "R-DDI-6791226", "R-DDI-4570464", "R-MMU-4570464", "R-HSA-6790901", "R-RNO-6791226", "R-HSA-72163", "R-SPO-4570464", "R-SCE-6791226", "R-HSA-6791226", "R-RNO-4570464", "R-HSA-4570464", "R-CEL-6791226", "R-SPO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Homologous_superfamily"}, "IPR036071": {"description": "AMMECR1 domain superfamily", "go_ids": [], "go_terms": [], "name": "AMMECR1_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036073": {"description": "Desulfoferrodoxin, ferrous iron-binding domain superfamily", "go_ids": ["GO:0005506", "GO:0016491"], "go_terms": ["GO:0005506:iron ion binding:F", "GO:0016491:oxidoreductase activity:F"], "name": "Desulfoferrodoxin_Fe-bd_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036074": {"description": "CbiD superfamily", "go_ids": ["GO:0008168", "GO:0009236"], "go_terms": ["GO:0008168:methyltransferase activity:F", "GO:0009236:cobalamin biosynthetic process:P"], "name": "CbiD_sf", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Homologous_superfamily"}, "IPR036075": {"description": "Damage-control phosphatase ARMT1-like, metal-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "ARMT-1-like_metal-bd_sf", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664", "R-MMU-199220", "R-RNO-199220", "R-HSA-199220"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Homologous_superfamily"}, "IPR036076": {"description": "Fructose-1,6-bisphosphatase, class V superfamily", "go_ids": [], "go_terms": [], "name": "FBPase_V_sf", "pathway_ids": ["PWY-1042", "PWY-8178", "PWY-8404", "PWY-6142", "PWY-1861", "PWY-7385", "PWY-5484"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)"], "type": "Homologous_superfamily"}, "IPR036078": {"description": "Spo11/DNA topoisomerase VI subunit A superfamily", "go_ids": ["GO:0003677", "GO:0005694"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005694:chromosome:C"], "name": "Spo11/TopoVI_A_sf", "pathway_ids": ["R-HSA-912446"], "pathways": ["R-HSA-912446:r:Meiotic recombination"], "type": "Homologous_superfamily"}, "IPR036079": {"description": "V-type ATP synthase subunit C/D subunit superfamily", "go_ids": [], "go_terms": [], "name": "ATPase_csu/dsu_sf", "pathway_ids": ["R-MMU-1222556", "R-DDI-77387", "R-SCE-9639288", "R-DME-1222556", "R-HSA-77387", "R-DRE-9639288", "R-HSA-9857377", "R-MMU-9639288", "R-SPO-9639288", "R-XTR-77387", "R-RNO-1222556", "R-GGA-917977", "R-HSA-9639288", "R-DRE-983712", "R-RNO-983712", "R-XTR-1222556", "R-HSA-1222556", "R-XTR-917977", "R-SPO-917977", "R-DRE-1222556", "R-SPO-1222556", "R-DDI-1222556", "R-GGA-9639288", "R-XTR-983712", "R-RNO-917977", "R-SCE-917977", "R-SCE-1222556", "R-MMU-77387", "R-DDI-9639288", "R-BTA-1222556", "R-SCE-77387", "R-HSA-381038", "R-DRE-917977", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-GGA-77387", "R-RNO-77387", "R-BTA-917977", "R-HSA-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-XTR-9639288", "R-RNO-9639288", "R-GGA-1222556", "R-DRE-77387", "R-DDI-917977", "R-MMU-983712", "R-DDI-983712", "R-HSA-917977", "R-BTA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-XTR-77387:r:Insulin receptor recycling", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-GGA-917977:r:Transferrin endocytosis and recycling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DRE-983712:r:Ion channel transport", "R-RNO-983712:r:Ion channel transport", "R-XTR-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-XTR-917977:r:Transferrin endocytosis and recycling", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-DRE-1222556:r:ROS and RNS production in phagocytes", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-GGA-9639288:r:Amino acids regulate mTORC1", "R-XTR-983712:r:Ion channel transport", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-MMU-77387:r:Insulin receptor recycling", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-SCE-77387:r:Insulin receptor recycling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DRE-917977:r:Transferrin endocytosis and recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-GGA-77387:r:Insulin receptor recycling", "R-RNO-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-GGA-1222556:r:ROS and RNS production in phagocytes", "R-DRE-77387:r:Insulin receptor recycling", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-BTA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR036080": {"description": "F420-dependent methylenetetrahydromethanopterin dehydrogenase superfamily", "go_ids": ["GO:0008901", "GO:0015948"], "go_terms": ["GO:0008901:ferredoxin hydrogenase activity:F", "GO:0015948:methanogenesis:P"], "name": "MTD_sf", "pathway_ids": ["PWY-8113", "PWY-5209", "PWY-8305", "PWY-8112", "PWY-5198"], "pathways": ["PWY-8113:t:3PG-factor 420 biosynthesis", "PWY-5209:t:methyl-coenzyme M oxidation to CO2 I", "PWY-8305:t:methoxylated aromatic compound degradation II", "PWY-8112:t:factor 420 biosynthesis I (archaea)", "PWY-5198:t:factor 420 biosynthesis II (mycobacteria)"], "type": "Homologous_superfamily"}, "IPR036081": {"description": "Translin superfamily", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "Translin_sf", "pathway_ids": ["R-MMU-426486", "R-HSA-426486", "R-RNO-426486", "R-BTA-426486", "R-SPO-426486"], "pathways": ["R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-BTA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-SPO-426486:r:Small interfering RNA (siRNA) biogenesis"], "type": "Homologous_superfamily"}, "IPR036082": {"description": "NSP3 superfamily", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "NSP3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036084": {"description": "Serine protease inhibitor-like superfamily", "go_ids": [], "go_terms": [], "name": "Ser_inhib-like_sf", "pathway_ids": ["R-HSA-5083632", "R-MMU-163125", "R-HSA-5674135", "R-MMU-5674135", "R-HSA-6802952", "R-HSA-9845620", "R-HSA-977068", "R-MMU-913709", "R-HSA-140837", "R-HSA-430116", "R-MMU-76009", "R-MMU-430116", "R-HSA-9845622", "R-HSA-9845621", "R-MMU-372708", "R-HSA-114608", "R-HSA-76009", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-9846298", "R-HSA-5083625", "R-HSA-9672391", "R-MMU-977068", "R-HSA-5621480", "R-HSA-6802955", "R-HSA-9672393", "R-HSA-354192", "R-HSA-5083636", "R-HSA-6802948", "R-HSA-216083", "R-HSA-5083635", "R-HSA-9662361", "R-MMU-140837", "R-HSA-9845619", "R-HSA-354194", "R-MMU-354194", "R-HSA-163125", "R-HSA-75892", "R-RNO-5173214", "R-MMU-114608", "R-HSA-5173214", "R-MMU-5173214", "R-MMU-216083", "R-HSA-372708", "R-MMU-354192", "R-HSA-913709", "R-HSA-9656223"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-354192:r:Integrin signaling", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-114608:r:Platelet degranulation", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Homologous_superfamily"}, "IPR036085": {"description": "PAZ domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "PAZ_dom_sf", "pathway_ids": ["R-SPO-426496", "R-HSA-9022692", "R-MMU-426496", "R-HSA-2559580", "R-HSA-8936459", "R-HSA-8948700", "R-HSA-9764562", "R-XTR-426496", "R-DRE-426496", "R-SPO-5578749", "R-SPO-426486", "R-CEL-203927", "R-HSA-9759811", "R-HSA-9824594", "R-HSA-9018519", "R-HSA-5601884", "R-XTR-5578749", "R-MMU-5578749", "R-HSA-8934593", "R-RNO-5578749", "R-DME-203927", "R-MMU-203927", "R-HSA-9768778", "R-XTR-426486", "R-HSA-9820841", "R-HSA-8986944", "R-HSA-426496", "R-DME-426496", "R-HSA-8853884", "R-HSA-426486", "R-RNO-203927", "R-HSA-5578749", "R-HSA-2559585", "R-DME-5578749", "R-HSA-5628897", "R-HSA-1912408", "R-HSA-203927", "R-HSA-9845323", "R-HSA-4086398", "R-HSA-9029569", "R-CEL-426486", "R-HSA-9839394", "R-HSA-8943723", "R-RNO-426496", "R-HSA-9708296", "R-MMU-426486", "R-RNO-426486", "R-HSA-9725371", "R-HSA-5687128", "R-HSA-9909620", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-SPO-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-XTR-426496:r:Post-transcriptional silencing by small RNAs", "R-DRE-426496:r:Post-transcriptional silencing by small RNAs", "R-SPO-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-XTR-5578749:r:Transcriptional regulation by small RNAs", "R-MMU-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-426496:r:Post-transcriptional silencing by small RNAs", "R-DME-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-RNO-426496:r:Post-transcriptional silencing by small RNAs", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Homologous_superfamily"}, "IPR036086": {"description": "ParB/Sulfiredoxin superfamily", "go_ids": [], "go_terms": [], "name": "ParB/Sulfiredoxin_sf", "pathway_ids": ["R-SCE-9818027", "R-MMU-9818027", "R-SPO-9818027", "R-DME-9818027", "R-HSA-9818027"], "pathways": ["R-SCE-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-MMU-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-SPO-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-DME-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes"], "type": "Homologous_superfamily"}, "IPR036087": {"description": "Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like superfamily", "go_ids": ["GO:0008939"], "go_terms": ["GO:0008939:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity:F"], "name": "Nict_dMeBzImd_PRibTrfase_sf", "pathway_ids": ["PWY-7970", "PWY-7969", "PWY-5509", "PWY-7964", "PWY-7968", "PWY-7966", "PWY-7965", "PWY-7967", "PWY-6269"], "pathways": ["PWY-7970:t:benzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7969:t:5-hydroxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-5509:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I", "PWY-7964:t:adeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7968:t:5-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7966:t:5-methoxy-6-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7965:t:2-methyladeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-7967:t:5-methoxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP", "PWY-6269:t:superpathway of adenosylcobalamin salvage from cobinamide II"], "type": "Homologous_superfamily"}, "IPR036091": {"description": "Propanediol/glycerol dehydratase, small subunit superfamily", "go_ids": [], "go_terms": [], "name": "Prodiol/glycerol_DeHase__sf_su", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036092": {"description": "Small/middle T-antigen superfamily", "go_ids": [], "go_terms": [], "name": "Papo_T_antigensf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036093": {"description": "NAC domain superfamily", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "NAC_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036094": {"description": "Quinolinate synthetase A superfamily", "go_ids": ["GO:0008987", "GO:0009435", "GO:0051539"], "go_terms": ["GO:0008987:quinolinate synthetase A activity:F", "GO:0009435:NAD+ biosynthetic process:P", "GO:0051539:4 iron, 4 sulfur cluster binding:F"], "name": "NadA_sf", "pathway_ids": ["PWY-7342", "PWY-5316", "PWY-8277", "PWY-8352"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-8277:t:NAD de novo biosynthesis IV (anaerobic)", "PWY-8352:t:NAD de novo biosynthesis III"], "type": "Homologous_superfamily"}, "IPR036095": {"description": "PTS system IIB component-like superfamily", "go_ids": ["GO:0008982", "GO:0009401"], "go_terms": ["GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PTS_EIIB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036096": {"description": "Ataxin, AXH domain superfamily", "go_ids": ["GO:0003723", "GO:0005515"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0005515:protein binding:F"], "name": "Ataxin_AXH_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036097": {"description": "Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily", "go_ids": ["GO:0000155", "GO:0007165"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F", "GO:0007165:signal transduction:P"], "name": "HisK_dim/P_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036098": {"description": "Thymidylate synthase ThyX superfamily", "go_ids": ["GO:0006231", "GO:0050660", "GO:0050797"], "go_terms": ["GO:0006231:dTMP biosynthetic process:P", "GO:0050660:flavin adenine dinucleotide binding:F", "GO:0050797:thymidylate synthase (FAD) activity:F"], "name": "Thymidylate_synthase_ThyX_sf", "pathway_ids": ["PWY-6545"], "pathways": ["PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III"], "type": "Homologous_superfamily"}, "IPR036099": {"description": "Cytochrome b6/f complex, subunit 5 superfamily", "go_ids": ["GO:0009512"], "go_terms": ["GO:0009512:cytochrome b6f complex:C"], "name": "Cyt_6/f_cplx_su5_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036100": {"description": "S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA superfamily", "go_ids": ["GO:0016740", "GO:0016853"], "go_terms": ["GO:0016740:transferase activity:F", "GO:0016853:isomerase activity:F"], "name": "QueA_sf", "pathway_ids": ["PWY-6700", "PWY-8106"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Homologous_superfamily"}, "IPR036101": {"description": "CarD-like/TRCF, RNAP-interacting domain superfamily", "go_ids": [], "go_terms": [], "name": "CarD-like/TRCF_RID_sf", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Homologous_superfamily"}, "IPR036102": {"description": "OsmC/Ohr superfamily", "go_ids": [], "go_terms": [], "name": "OsmC/Ohrsf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036104": {"description": "Bifunctional nuclease superfamily", "go_ids": ["GO:0004518"], "go_terms": ["GO:0004518:nuclease activity:F"], "name": "BFN_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036105": {"description": "Dinitrogenase iron-molybdenum cofactor biosynthesis superfamily", "go_ids": [], "go_terms": [], "name": "DiNase_FeMo-co_biosyn_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036107": {"description": "Carbon storage regulator superfamily", "go_ids": ["GO:0003723", "GO:0006109", "GO:0006402"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006109:regulation of carbohydrate metabolic process:P", "GO:0006402:mRNA catabolic process:P"], "name": "CsrA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036108": {"description": "Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily", "go_ids": ["GO:0004852", "GO:0033014"], "go_terms": ["GO:0004852:uroporphyrinogen-III synthase activity:F", "GO:0033014:tetrapyrrole biosynthetic process:P"], "name": "4pyrrol_syn_uPrphyn_synt_sf", "pathway_ids": ["PWY-5188", "PWY-5189", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "PWY-5189:t:tetrapyrrole biosynthesis II (from glycine)", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Homologous_superfamily"}, "IPR036111": {"description": "Malate/L-sulfolactate/L-lactate dehydrogenase-like superfamily", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Mal/L-sulfo/L-lacto_DH-like_sf", "pathway_ids": ["PWY-6961"], "pathways": ["PWY-6961:t:L-ascorbate degradation II (bacterial, aerobic)"], "type": "Homologous_superfamily"}, "IPR036112": {"description": "(2R)-phospho-3-sulpholactate synthase, ComA superfamily", "go_ids": [], "go_terms": [], "name": "ComA_synth_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036113": {"description": "Glu-tRNAGln amidotransferase superfamily, subunit C", "go_ids": ["GO:0006450"], "go_terms": ["GO:0006450:regulation of translational fidelity:P"], "name": "Asp/Glu-ADT_sf_sub_c", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Homologous_superfamily"}, "IPR036115": {"description": "GCM domain superfamily", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "GCM_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036116": {"description": "Fibronectin type III superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "FN3_sf", "pathway_ids": ["R-RNO-9013149", "R-RNO-9020956", "R-HSA-9013424", "R-MMU-9013404", "R-MMU-8957275", "R-HSA-3928662", "R-HSA-1650814", "R-MMU-2214320", "R-HSA-4420097", "R-DME-9749641", "R-MMU-3000178", "R-HSA-9649948", "R-RNO-202733", "R-GGA-8957275", "R-MMU-9020558", "R-GGA-3000170", "R-HSA-6783783", "R-HSA-381426", "R-GGA-8854691", "R-RNO-2404192", "R-HSA-8932505", "R-MMU-8849932", "R-CEL-9764561", "R-MMU-390522", "R-MMU-982772", "R-GGA-202733", "R-MMU-445144", "R-HSA-6785807", "R-HSA-8854691", "R-RNO-77387", "R-DRE-210993", "R-RNO-418885", "R-HSA-982772", "R-DME-388844", "R-HSA-9013404", "R-MMU-264642", "R-HSA-9013149", "R-DME-110478", "R-HSA-8980692", "R-HSA-5688890", "R-DME-445144", "R-HSA-5683826", "R-RNO-264642", "R-HSA-418890", "R-MMU-376172", "R-HSA-5689603", "R-HSA-9860927", "R-HSA-372708", "R-HSA-376172", "R-HSA-9674555", "R-RNO-8849932", "R-RNO-983168", "R-RNO-181429", "R-CEL-6809371", "R-MMU-375165", "R-MMU-419037", "R-CEL-375165", "R-HSA-449836", "R-HSA-2122948", "R-MMU-8856825", "R-HSA-3000157", "R-HSA-9034015", "R-MMU-8948216", "R-HSA-418889", "R-HSA-418886", "R-MMU-9010553", "R-CEL-416700", "R-HSA-416476", "R-HSA-418885", "R-RNO-354194", "R-RNO-2129379", "R-CEL-9013149", "R-MMU-372708", "R-CEL-418885", "R-CEL-1474228", "R-HSA-76009", "R-RNO-418889", "R-HSA-3214841", "R-HSA-6802946", "R-RNO-8957275", "R-DME-9913351", "R-MMU-2428928", "R-HSA-912694", "R-MMU-6788467", "R-RNO-5654687", "R-MMU-5689603", "R-RNO-373752", "R-RNO-8932505", "R-HSA-354192", "R-DRE-2682334", "R-MMU-8854691", "R-HSA-193648", "R-RNO-112411", "R-MMU-8932505", "R-CEL-9913351", "R-HSA-9013420", "R-RNO-210991", "R-DME-376172", "R-SSC-9027276", "R-MMU-8984722", "R-DRE-9843970", "R-HSA-1566977", "R-DME-77387", "R-HSA-428542", "R-BTA-9020958", "R-HSA-190373", "R-MMU-2682334", "R-MMU-3928663", "R-MMU-8985586", "R-HSA-354194", "R-HSA-9679191", "R-MMU-9006335", "R-MMU-181429", "R-MMU-877300", "R-HSA-1433557", "R-MMU-2404192", "R-HSA-9851151", "R-DME-8849932", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-DME-2022928", "R-GGA-1566977", "R-DRE-3214841", "R-HSA-5687128", "R-BTA-909733", "R-CEL-1971475", "R-HSA-9705462", "R-DME-3000171", "R-MMU-983168", "R-DME-209228", "R-HSA-2892247", "R-MMU-9696270", "R-MMU-1442490", "R-CEL-3000171", "R-DRE-3928663", "R-MMU-8856828", "R-HSA-8874081", "R-HSA-9942503", "R-HSA-9020958", "R-HSA-6802952", "R-RNO-372708", "R-MMU-3928665", "R-HSA-8951664", "R-HSA-77387", "R-RNO-74752", "R-MMU-6811558", "R-RNO-9020558", "R-BTA-5673001", "R-MMU-181430", "R-HSA-9010553", "R-HSA-9732724", "R-GGA-354192", "R-HSA-9027284", "R-MMU-418889", "R-HSA-9010642", "R-DRE-388844", "R-DME-3000178", "R-DRE-3928664", "R-SSC-9020933", "R-MMU-9020958", "R-HSA-5632681", "R-MMU-9732724", "R-MMU-202733", "R-HSA-8948216", "R-CEL-9772755", "R-RNO-375165", "R-HSA-512988", "R-HSA-9696273", "R-MMU-909733", "R-SSC-1170546", "R-RNO-416476", "R-HSA-6802955", "R-HSA-210991", "R-RNO-193648", "R-HSA-8984722", "R-CEL-428542", "R-HSA-196108", "R-HSA-74713", "R-HSA-6802948", "R-HSA-1170546", "R-DME-210991", "R-DME-9772755", "R-GGA-2129379", "R-MMU-9634597", "R-HSA-3000171", "R-HSA-437239", "R-GGA-5654726", "R-HSA-373752", "R-HSA-419037", "R-HSA-163125", "R-HSA-9820960", "R-DME-216083", "R-MMU-912526", "R-HSA-909733", "R-DRE-381426", "R-CEL-2682334", "R-MMU-216083", "R-RNO-388844", "R-DME-416700", "R-HSA-140834", "R-MMU-9696264", "R-GGA-9860927", "R-MMU-6785807", "R-MMU-354192", "R-HSA-9833109", "R-HSA-9634597", "R-BTA-8985947", "R-GGA-3000178", "R-CFA-2024096", "R-MMU-5674135", "R-RNO-216083", "R-HSA-1059683", "R-DME-1971475", "R-GGA-1474228", "R-DRE-3928662", "R-RNO-8980692", "R-MMU-140834", "R-HSA-6788467", "R-HSA-8849932", "R-HSA-9824272", "R-CEL-2024096", "R-RNO-9860927", "R-RNO-8874081", "R-MMU-196108", "R-HSA-114608", "R-HSA-388844", "R-MMU-9020591", "R-RNO-416482", "R-RNO-354192", "R-HSA-877312", "R-XTR-8932505", "R-RNO-140834", "R-RNO-3928662", "R-RNO-5674135", "R-RNO-6788467", "R-GGA-449836", "R-HSA-9706369", "R-MMU-3214847", "R-HSA-9925563", "R-MMU-74713", "R-HSA-3000170", "R-MMU-1566977", "R-HSA-9696270", "R-RNO-437239", "R-DME-6798695", "R-HSA-5654726", "R-RNO-210500", "R-XTR-5654687", "R-MMU-9013424", "R-MMU-210500", "R-MMU-354194", "R-BTA-8849932", "R-RNO-5632681", "R-CEL-9749641", "R-HSA-74749", "R-HSA-110056", "R-RNO-3928664", "R-HSA-6807004", "R-RNO-74713", "R-GGA-9843940", "R-HSA-9009391", "R-HSA-9725371", "R-HSA-8856825", "R-HSA-3928665", "R-MMU-5654687", "R-HSA-428540", "R-BTA-210993", "R-HSA-9027277", "R-HSA-3214847", "R-HSA-2428928", "R-HSA-428890", "R-MMU-9696273", "R-HSA-9725370", "R-DME-210688", "R-DRE-8932505", "R-HSA-186797", "R-MMU-416476", "R-HSA-6798695", "R-CEL-2022928", "R-HSA-2151201", "R-SSC-9020591", "R-HSA-8856828", "R-MMU-5694530", "R-CEL-6798695", "R-HSA-112411", "R-MMU-74752", "R-MMU-373756", "R-MMU-4420097", "R-RNO-8983432", "R-RNO-9027276", "R-CEL-5673001", "R-DRE-5673001", "R-HSA-5694530", "R-RNO-912526", "R-RNO-212676", "R-RNO-202427", "R-RNO-9772755", "R-RNO-3928665", "R-MMU-381426", "R-MMU-373752", "R-CFA-2024101", "R-MMU-74751", "R-RNO-9013408", "R-HSA-9013408", "R-CEL-3928662", "R-RNO-3000178", "R-RNO-5673001", "R-HSA-1266695", "R-CEL-525793", "R-MMU-1474228", "R-HSA-373753", "R-HSA-447043", "R-CEL-216083", "R-MMU-2428933", "R-HSA-2404192", "R-MMU-1433557", "R-MMU-5635838", "R-HSA-3928664", "R-HSA-210993", "R-GGA-216083", "R-RNO-8984722", "R-RNO-3928663", "R-HSA-264642", "R-HSA-9020933", "R-RNO-163125", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-381426", "R-HSA-204005", "R-MMU-373753", "R-BTA-445355", "R-MMU-445095", "R-MMU-9013406", "R-HSA-5635838", "R-MMU-6798695", "R-MMU-202427", "R-MMU-9027276", "R-GGA-9843970", "R-RNO-376172", "R-MMU-416700", "R-CEL-419037", "R-MMU-114608", "R-CEL-8863795", "R-HSA-9725554", "R-DME-419037", "R-HSA-74751", "R-HSA-5654687", "R-HSA-977225", "R-MMU-112411", "R-RNO-373760", "R-RNO-1059683", "R-HSA-375165", "R-RNO-114608", "R-BTA-5627123", "R-RNO-5689603", "R-HSA-416700", "R-CEL-3928663", "R-RNO-110056", "R-DME-5689603", "R-DME-9009391", "R-MMU-110056", "R-HSA-525793", "R-DME-2024096", "R-HSA-2214320", "R-HSA-9020591", "R-MMU-1170546", "R-CEL-210991", "R-DRE-9843940", "R-HSA-216083", "R-RNO-390522", "R-HSA-445355", "R-HSA-373756", "R-CEL-445144", "R-MMU-428890", "R-RNO-982772", "R-HSA-983168", "R-RNO-196108", "R-BTA-8932505", "R-RNO-2428928", "R-DME-447043", "R-MMU-1059683", "R-RNO-74751", "R-HSA-3928663", "R-HSA-5627123", "R-MMU-6783783", "R-MMU-416482", "R-MMU-3928662", "R-HSA-390522", "R-GGA-190373", "R-HSA-9843940", "R-DRE-3928665", "R-HSA-8957275", "R-HSA-9013406", "R-CEL-376176", "R-MMU-912694", "R-RNO-449836", "R-BTA-6785807", "R-CEL-5218920", "R-MMU-2129379", "R-MMU-418885", "R-RNO-445095", "R-RNO-6785807", "R-CEL-3928664", "R-MMU-210991", "R-MMU-1266695", "R-HSA-3000178", "R-RNO-1474228", "R-HSA-9006335", "R-RNO-2428933", "R-HSA-9918485", "R-MMU-9013408", "R-RNO-9009391", "R-RNO-373753", "R-CEL-3000178", "R-RNO-5687128", "R-MMU-210993", "R-MMU-9009391", "R-MMU-445355", "R-RNO-8854691", "R-MMU-3000170", "R-RNO-525793", "R-BTA-912694", "R-RNO-9634597", "R-HSA-202427", "R-MMU-5632681", "R-HSA-2979096", "R-MMU-9013420", "R-RNO-6811558", "R-BTA-9020558", "R-CEL-388844", "R-SSC-982772", "R-HSA-2682334", "R-HSA-9616222", "R-DME-209209", "R-HSA-446107", "R-HSA-447038", "R-MMU-5673001", "R-HSA-210500", "R-HSA-9027283", "R-MMU-449836", "R-HSA-9701898", "R-BTA-140834", "R-HSA-2586552", "R-HSA-1474228", "R-MMU-77387", "R-HSA-181430", "R-MMU-3214841", "R-HSA-182971", "R-RNO-1566977", "R-MMU-9843940", "R-RNO-445144", "R-DME-433692", "R-HSA-416482", "R-CEL-447043", "R-HSA-8983432", "R-BTA-8983432", "R-SSC-9027284", "R-HSA-447041", "R-DRE-8849932", "R-GGA-5674135", "R-HSA-9696264", "R-MMU-9013423", "R-MMU-376176", "R-HSA-2022090", "R-RNO-9006335", "R-RNO-8951664", "R-MMU-193648", "R-HSA-445144", "R-MMU-5627123", "R-MMU-9851151", "R-MMU-5687128", "R-HSA-9031628", "R-GGA-8932505", "R-BTA-77387", "R-HSA-212676", "R-HSA-8985947", "R-MMU-9860927", "R-MMU-446107", "R-RNO-6798695", "R-HSA-9656223", "R-GGA-9634597", "R-CEL-8849932", "R-DME-983168", "R-DME-5673001", "R-HSA-9705671", "R-HSA-445095", "R-HSA-9772755", "R-RNO-9851151", "R-MMU-8980692", "R-GGA-163125", "R-MMU-9020956", "R-HSA-2428933", "R-HSA-373760", "R-RNO-9027284", "R-MMU-388844", "R-DME-209338", "R-HSA-9013423", "R-HSA-181429", "R-HSA-9638630", "R-BTA-1266695", "R-MMU-8874081", "R-BTA-912526", "R-HSA-9843970", "R-CEL-373752", "R-MMU-512988", "R-MMU-9772755", "R-GGA-381426", "R-MMU-9027284", "R-HSA-1442490", "R-DRE-8957275", "R-MMU-3928664", "R-CEL-9013423", "R-HSA-9020558", "R-RNO-1170546", "R-MMU-877312", "R-HSA-9027276", "R-MMU-437239", "R-DME-428542", "R-HSA-2129379", "R-HSA-8939247", "R-RNO-446107", "R-MMU-212676", "R-RNO-416700", "R-HSA-8985801", "R-BTA-388844", "R-CFA-6788467", "R-RNO-2682334", "R-RNO-447043", "R-DME-5658623", "R-RNO-181430", "R-MMU-9706369", "R-HSA-376176", "R-SSC-9006335", "R-GGA-114608", "R-MMU-8983432", "R-MMU-447043", "R-CEL-77387", "R-CEL-3928665", "R-DME-1474228", "R-CFA-6785807", "R-RNO-3214847", "R-DME-3214847", "R-MMU-1650814", "R-HSA-74752", "R-HSA-912526", "R-HSA-877300", "R-GGA-3214841", "R-CEL-9013420", "R-MMU-6807004", "R-MMU-525793", "R-MMU-9013149", "R-RNO-3000170", "R-RNO-419037", "R-HSA-9020956", "R-HSA-202733", "R-MMU-373760", "R-DRE-1433557", "R-CEL-433692", "R-GGA-372708", "R-MMU-74749", "R-HSA-5688849", "R-MMU-8985947", "R-MMU-182971", "R-MMU-163125", "R-BTA-983168", "R-HSA-5674135", "R-MMU-204005", "R-CEL-373753", "R-HSA-9700645", "R-DME-375165", "R-MMU-9020933", "R-CEL-9013424", "R-RNO-74749", "R-GGA-354194"], "pathways": ["R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2214320:r:Anchoring fibril formation", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9749641:r:Aspirin ADME", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-MMU-9020558:r:Interleukin-2 signaling", "R-GGA-3000170:r:Syndecan interactions", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-8854691:r:Interleukin-20 family signaling", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-MMU-390522:r:Striated Muscle Contraction", "R-MMU-982772:r:Growth hormone receptor signaling", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-RNO-77387:r:Insulin receptor recycling", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-110478:r:Insulin signaling pathway", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-DME-445144:r:Signal transduction by L1", "R-HSA-5683826:r:Surfactant metabolism", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-MMU-376172:r:DSCAM interactions", "R-HSA-5689603:r:UCH proteinases", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-376172:r:DSCAM interactions", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-6809371:r:Formation of the cornified envelope", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-MMU-419037:r:NCAM1 interactions", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-449836:r:Other interleukin signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000157:r:Laminin interactions", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-MMU-8948216:r:Collagen chain trimerization", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-416700:r:Other semaphorin interactions", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CEL-418885:r:DCC mediated attractive signaling", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-5689603:r:UCH proteinases", "R-RNO-373752:r:Netrin-1 signaling", "R-RNO-8932505:r:DAG1 core M3 glycosylations", "R-HSA-354192:r:Integrin signaling", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-210991:r:Basigin interactions", "R-DME-376172:r:DSCAM interactions", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-1566977:r:Fibronectin matrix formation", "R-DME-77387:r:Insulin receptor recycling", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-BTA-9020958:r:Interleukin-21 signaling", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-MMU-877300:r:Interferon gamma signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-DME-2022928:r:HS-GAG biosynthesis", "R-GGA-1566977:r:Fibronectin matrix formation", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-1442490:r:Collagen degradation", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8951664:r:Neddylation", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-74752:r:Signaling by Insulin receptor", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-GGA-354192:r:Integrin signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-3000178:r:ECM proteoglycans", "R-DRE-3928664:r:Ephrin signaling", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-HSA-5632681:r:Ligand-receptor interactions", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-8948216:r:Collagen chain trimerization", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-CEL-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-HSA-74713:r:IRS activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DME-210991:r:Basigin interactions", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-GGA-2129379:r:Molecules associated with elastic fibres", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-437239:r:Recycling pathway of L1", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-416700:r:Other semaphorin interactions", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-GGA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-354192:r:Integrin signaling", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9634597:r:GPER1 signaling", "R-BTA-8985947:r:Interleukin-9 signaling", "R-GGA-3000178:r:ECM proteoglycans", "R-CFA-2024096:r:HS-GAG degradation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9824272:r:Somitogenesis", "R-CEL-2024096:r:HS-GAG degradation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-114608:r:Platelet degranulation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9020591:r:Interleukin-12 signaling", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-354192:r:Integrin signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-XTR-8932505:r:DAG1 core M3 glycosylations", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-449836:r:Other interleukin signaling", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-MMU-74713:r:IRS activation", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-XTR-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5632681:r:Ligand-receptor interactions", "R-CEL-9749641:r:Aspirin ADME", "R-HSA-74749:r:Signal attenuation", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-RNO-74713:r:IRS activation", "R-GGA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-428540:r:Activation of RAC1", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-HSA-186797:r:Signaling by PDGF", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SSC-9020591:r:Interleukin-12 signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-74752:r:Signaling by Insulin receptor", "R-MMU-373756:r:SDK interactions", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-373752:r:Netrin-1 signaling", "R-CFA-2024101:r:CS/DS degradation", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-RNO-3000178:r:ECM proteoglycans", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-1266695:r:Interleukin-7 signaling", "R-CEL-525793:r:Myogenesis", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-447043:r:Neurofascin interactions", "R-CEL-216083:r:Integrin cell surface interactions", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-5635838:r:Activation of SMO", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-210993:r:Tie2 Signaling", "R-GGA-216083:r:Integrin cell surface interactions", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9020933:r:Interleukin-23 signaling", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-373753:r:Nephrin family interactions", "R-BTA-445355:r:Smooth Muscle Contraction", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-5635838:r:Activation of SMO", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-GGA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-RNO-376172:r:DSCAM interactions", "R-MMU-416700:r:Other semaphorin interactions", "R-CEL-419037:r:NCAM1 interactions", "R-MMU-114608:r:Platelet degranulation", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-DME-419037:r:NCAM1 interactions", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-373760:r:L1CAM interactions", "R-RNO-1059683:r:Interleukin-6 signaling", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-114608:r:Platelet degranulation", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-5689603:r:UCH proteinases", "R-HSA-416700:r:Other semaphorin interactions", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DME-5689603:r:UCH proteinases", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-525793:r:Myogenesis", "R-DME-2024096:r:HS-GAG degradation", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-210991:r:Basigin interactions", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-373756:r:SDK interactions", "R-CEL-445144:r:Signal transduction by L1", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-BTA-8932505:r:DAG1 core M3 glycosylations", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-DME-447043:r:Neurofascin interactions", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-MMU-6783783:r:Interleukin-10 signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-390522:r:Striated Muscle Contraction", "R-GGA-190373:r:FGFR1c ligand binding and activation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-CEL-376176:r:Signaling by ROBO receptors", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-449836:r:Other interleukin signaling", "R-BTA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-418885:r:DCC mediated attractive signaling", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-210991:r:Basigin interactions", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-373753:r:Nephrin family interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-210993:r:Tie2 Signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-MMU-3000170:r:Syndecan interactions", "R-RNO-525793:r:Myogenesis", "R-BTA-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-9634597:r:GPER1 signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-9020558:r:Interleukin-2 signaling", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-SSC-982772:r:Growth hormone receptor signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-DME-209209:r:Formation of the activated receptor complex", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-447038:r:NrCAM interactions", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-BTA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-182971:r:EGFR downregulation", "R-RNO-1566977:r:Fibronectin matrix formation", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-RNO-445144:r:Signal transduction by L1", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-447043:r:Neurofascin interactions", "R-HSA-8983432:r:Interleukin-15 signaling", "R-BTA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-447041:r:CHL1 interactions", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-RNO-8951664:r:Neddylation", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9031628:r:NGF-stimulated transcription", "R-GGA-8932505:r:DAG1 core M3 glycosylations", "R-BTA-77387:r:Insulin receptor recycling", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-GGA-9634597:r:GPER1 signaling", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-373760:r:L1CAM interactions", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-CEL-373752:r:Netrin-1 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-HSA-1442490:r:Collagen degradation", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-HSA-9020558:r:Interleukin-2 signaling", "R-RNO-1170546:r:Prolactin receptor signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-437239:r:Recycling pathway of L1", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-416700:r:Other semaphorin interactions", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-CFA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-RNO-447043:r:Neurofascin interactions", "R-DME-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-376176:r:Signaling by ROBO receptors", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-GGA-114608:r:Platelet degranulation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-MMU-447043:r:Neurofascin interactions", "R-CEL-77387:r:Insulin receptor recycling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-CFA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-74752:r:Signaling by Insulin receptor", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-GGA-3214841:r:PKMTs methylate histone lysines", "R-CEL-9013420:r:RHOU GTPase cycle", "R-MMU-6807004:r:Negative regulation of MET activity", "R-MMU-525793:r:Myogenesis", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-RNO-419037:r:NCAM1 interactions", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-373760:r:L1CAM interactions", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-CEL-433692:r:Proton-coupled monocarboxylate transport", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-74749:r:Signal attenuation", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-CEL-373753:r:Nephrin family interactions", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9020933:r:Interleukin-23 signaling", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-74749:r:Signal attenuation", "R-GGA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins"], "type": "Homologous_superfamily"}, "IPR036117": {"description": "DhaL domain superfamily", "go_ids": ["GO:0004371", "GO:0006071"], "go_terms": ["GO:0004371:glycerone kinase activity:F", "GO:0006071:glycerol metabolic process:P"], "name": "DhaL_dom_sf", "pathway_ids": ["R-SCE-70350", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9692916", "R-SPO-70350", "R-HSA-70350", "R-RNO-70350", "R-DDI-70350", "R-MMU-70350"], "pathways": ["R-SCE-70350:r:Fructose catabolism", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-SPO-70350:r:Fructose catabolism", "R-HSA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-DDI-70350:r:Fructose catabolism", "R-MMU-70350:r:Fructose catabolism"], "type": "Homologous_superfamily"}, "IPR036118": {"description": "UreE urease accessory, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "UreE_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036119": {"description": "Nitric oxide synthase, N-terminal domain superfamily", "go_ids": ["GO:0004517", "GO:0006809"], "go_terms": 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"R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-DME-203754:r:NOSIP mediated eNOS trafficking", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Homologous_superfamily"}, "IPR036120": {"description": "Staphylokinase/Streptokinase superfamily", "go_ids": 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mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR036133": {"description": "EB1, C-terminal domain superfamily", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "EB1_C_sf", "pathway_ids": ["R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-MMU-8852276", "R-XTR-2467813", "R-HSA-9918485", "R-HSA-380284", "R-XTR-380270", "R-BTA-5663220", "R-MMU-68877", "R-RNO-5620912", "R-XTR-8854518", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-BTA-380259", "R-RNO-380320", "R-HSA-2565942", "R-XTR-141444", "R-HSA-380320", "R-XTR-5620912", "R-BTA-2467813", "R-RNO-2565942", "R-BTA-2565942", "R-HSA-68877", "R-BTA-5620912", "R-RNO-380284", "R-BTA-2500257", "R-BTA-380320", "R-RNO-8852276", "R-MMU-5620912", "R-HSA-5620912", "R-MMU-9648025", "R-BTA-380284", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-HSA-2500257", "R-MMU-141444", "R-MMU-380259", "R-RNO-8854518", "R-HSA-8852276", "R-HSA-141444", "R-MMU-380270", "R-XTR-5663220", "R-XTR-380284", "R-HSA-9648025", "R-HSA-380270", "R-XTR-68877", "R-RNO-5663220", "R-XTR-380259", "R-XTR-8852276", "R-XTR-380320", "R-RNO-380259", "R-BTA-380270", "R-BTA-8854518", "R-XTR-2565942", "R-MMU-8854518", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-BTA-9648025", "R-HSA-380259", "R-BTA-141444", "R-XTR-2500257", "R-RNO-380270", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Homologous_superfamily"}, "IPR036134": {"description": "Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily", "go_ids": [], "go_terms": [], "name": "Crypto/Photolyase_FAD-like_sf", "pathway_ids": ["R-HSA-9931510", "R-DME-432553", "R-DME-432395", "R-HSA-9931530", "R-HSA-9932298", "R-HSA-9931521", "R-DME-538864"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-432395:r:Degradation of TIM", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-DME-538864:r:Degradation of CRY"], "type": "Homologous_superfamily"}, "IPR036135": {"description": "MoeA, N-terminal and linker domain superfamily", "go_ids": ["GO:0032324"], "go_terms": ["GO:0032324:molybdopterin cofactor biosynthetic process:P"], "name": "MoeA_linker/N_sf", "pathway_ids": ["PWY-8171", "R-DME-947581", "R-RNO-947581", "R-DDI-947581", "R-HSA-947581", "R-MMU-947581"], "pathways": ["PWY-8171:t:molybdenum cofactor biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Homologous_superfamily"}, "IPR036136": {"description": "Nitrite/Sulfite reductase ferredoxin-like domain superfamily", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Nit/Sulf_reduc_fer-like_dom_sf", "pathway_ids": ["PWY-6683", "R-MTU-936721"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Homologous_superfamily"}, "IPR036137": {"description": "Focal adhesion kinase, targeting (FAT) domain superfamily", "go_ids": ["GO:0006468", "GO:0007172", "GO:0004713", "GO:0005925"], "go_terms": ["GO:0006468:protein phosphorylation:P", "GO:0007172:signal complex assembly:P", "GO:0004713:protein tyrosine kinase activity:F", "GO:0005925:focal adhesion:C"], "name": "Focal_adhe_kin_target_dom_sf", "pathway_ids": ["R-HSA-5663213", "R-CEL-375165", "R-HSA-8874081", "R-RNO-372708", "R-RNO-9020558", "R-CEL-354194", "R-RNO-9009391", "R-MMU-9009391", "R-MMU-4420097", "R-HSA-418885", "R-RNO-354194", "R-HSA-375165", "R-CEL-5673001", "R-HSA-3928662", "R-RNO-2029482", "R-RNO-9860927", "R-RNO-111465", "R-RNO-8874081", "R-HSA-4420097", "R-RNO-5663213", "R-MMU-372708", "R-MMU-5663213", "R-MMU-8874081", "R-CEL-418885", "R-MMU-9013420", "R-RNO-354192", "R-CEL-354192", "R-RNO-3928662", "R-MMU-9020558", "R-RNO-375165", "R-MMU-375165", "R-CEL-3928662", "R-RNO-5673001", "R-MMU-111465", "R-MMU-5673001", "R-HSA-9020558", "R-HSA-354192", "R-HSA-9664422", "R-HSA-9013420", "R-CEL-9860927", "R-MMU-391160", "R-HSA-354194", "R-RNO-391160", "R-MMU-354194", "R-HSA-2029482", "R-CEL-5663213", "R-HSA-9634638", "R-MMU-2029482", "R-RNO-418885", "R-HSA-5673001", "R-CEL-2029482", "R-MMU-9860927", "R-HSA-9009391", "R-CEL-4420097", "R-MMU-3928662", "R-HSA-111465", "R-CEL-9013420", "R-CEL-9009391", "R-HSA-9860927", "R-HSA-372708", "R-CEL-8874081", "R-RNO-9013420", "R-MMU-354192", "R-RNO-4420097", "R-HSA-391160", "R-MMU-418885"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-9020558:r:Interleukin-2 signaling", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-418885:r:DCC mediated attractive signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-CEL-418885:r:DCC mediated attractive signaling", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9020558:r:Interleukin-2 signaling", "R-HSA-354192:r:Integrin signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-354192:r:Integrin signaling", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Homologous_superfamily"}, "IPR036138": {"description": "Penicillin-binding protein, dimerisation domain superfamily", "go_ids": ["GO:0008658"], "go_terms": ["GO:0008658:penicillin binding:F"], "name": "PBP_dimer_sf", "pathway_ids": ["PWY-6471", "PWY-5265"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)"], "type": "Homologous_superfamily"}, "IPR036139": {"description": "Virulence-associated V antigen superfamily", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Vir_assoc_V_ag_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036140": {"description": "Profilin superfamily", "go_ids": [], "go_terms": [], "name": "PFN_sf", "pathway_ids": ["R-HSA-114608", "R-MMU-376176", "R-BTA-4086400", "R-RNO-4086400", "R-HSA-4086400", "R-HSA-376176", "R-MMU-4086400", "R-HSA-5663220", "R-BTA-5663220", "R-RNO-5663220", "R-MMU-5663220"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-MMU-376176:r:Signaling by ROBO receptors", "R-BTA-4086400:r:PCP/CE pathway", "R-RNO-4086400:r:PCP/CE pathway", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-376176:r:Signaling by ROBO receptors", "R-MMU-4086400:r:PCP/CE pathway", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Homologous_superfamily"}, "IPR036141": {"description": "MukF, middle domain superfamily", "go_ids": [], "go_terms": [], "name": "MukF_M_sp", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036142": {"description": "ENT domain-like superfamily", "go_ids": [], "go_terms": [], "name": "ENT_dom-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036143": {"description": "Cytochrome b6-f complex, subunit 8 superfamily", "go_ids": ["GO:0017004", "GO:0009512"], "go_terms": ["GO:0017004:cytochrome complex assembly:P", "GO:0009512:cytochrome b6f complex:C"], "name": "Cytochr_b6-f_cplx_su8_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036144": {"description": "GTP cyclohydrolase II superfamily", "go_ids": [], "go_terms": [], "name": "RibA-like_sf", "pathway_ids": ["PWY-7539", "PWY-6168", "PWY-7991"], "pathways": ["PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-7991:t:toxoflavin biosynthesis"], "type": "Homologous_superfamily"}, "IPR036145": {"description": "Septum formation inhibitor MinC, C-terminal domain superfamily", "go_ids": ["GO:0000902"], "go_terms": ["GO:0000902:cell morphogenesis:P"], "name": "MinC_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036146": {"description": "Cyclotide superfamily", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "Cyclotide_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036147": {"description": "Anti sigma-E protein RseA, N-terminal domain superfamily", "go_ids": ["GO:0016989"], "go_terms": ["GO:0016989:sigma factor antagonist activity:F"], "name": "Anti-sigma_E_RseA_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036148": {"description": "MmgE/PrpD superfamily", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "MmgE/PrpD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036149": {"description": "APC, N-terminal coiled-coil domain superfamily", "go_ids": [], "go_terms": [], "name": "APC_N_sf", "pathway_ids": ["R-HSA-5358751", "R-HSA-5358752", "R-HSA-5358749", "R-MMU-3769402", "R-MMU-196299", "R-HSA-3769402", "R-RNO-4641262", "R-HSA-5689896", "R-HSA-5467348", "R-MMU-5689896", "R-HSA-196299", "R-HSA-5467340", "R-RNO-111465", "R-HSA-5358747", "R-RNO-196299", "R-HSA-5339716", "R-HSA-5467337", "R-MMU-4641262", "R-HSA-4641262", "R-HSA-111465", "R-MMU-111465", "R-RNO-3769402", "R-RNO-5689896", "R-HSA-5467333", "R-RNO-195253", "R-MMU-195253", "R-HSA-195253"], "pathways": ["R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467333:r:APC truncation mutants are not K63 polyubiquitinated", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Homologous_superfamily"}, "IPR036150": {"description": "Cytochrome b/b6, C-terminal domain superfamily", "go_ids": ["GO:0016491", "GO:0009055", "GO:0016020"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0009055:electron transfer activity:F", "GO:0016020:membrane:C"], "name": "Cyt_b/b6_C_sf", "pathway_ids": ["R-HSA-9865881", "R-HSA-5419276", "R-DDI-611105", "R-DRE-611105", "R-DRE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-RNO-5419276", "R-CEL-611105", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-BTA-9865881", "R-RNO-9865881", "R-SPO-611105", "R-CEL-5419276", "R-SCE-611105", "R-DRE-5419276", "R-BTA-611105", "R-DME-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DDI-611105:r:Respiratory electron transport", "R-DRE-611105:r:Respiratory electron transport", "R-DRE-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-5419276:r:Mitochondrial translation termination", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-BTA-9865881:r:Complex III assembly", "R-RNO-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-CEL-5419276:r:Mitochondrial translation termination", "R-SCE-611105:r:Respiratory electron transport", "R-DRE-5419276:r:Mitochondrial translation termination", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR036152": {"description": "Asparaginase/glutaminase-like superfamily", "go_ids": [], "go_terms": [], "name": "Asp/glu_Ase-like_sf", "pathway_ids": ["R-HSA-8963693", "R-RNO-8963693", "R-MMU-8963693"], "pathways": ["R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-MMU-8963693:r:Aspartate and asparagine metabolism"], "type": "Homologous_superfamily"}, "IPR036153": {"description": "Erythrocruorin linker subunit, C-terminal superfamily", "go_ids": [], "go_terms": [], "name": "Eryth_link_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036154": {"description": "Tp47, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Tp47_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036155": {"description": "Cryptochrome/photolyase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Crypto/Photolyase_N_sf", "pathway_ids": ["R-HSA-9931510", "R-DME-432553", "R-DME-432395", "R-HSA-9931530", "R-HSA-9932298", "R-HSA-9931521", "R-DME-538864"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-432395:r:Degradation of TIM", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-DME-538864:r:Degradation of CRY"], "type": "Homologous_superfamily"}, "IPR036156": {"description": "Beta-Galactosidase/glucuronidase domain superfamily", "go_ids": [], "go_terms": [], "name": "Beta-gal/glucu_dom_sf", "pathway_ids": ["R-HSA-2024101", "R-HSA-6798695", "R-SSC-2160916", "R-SSC-6798695", "R-MMU-8853383", "R-CEL-6798695", "R-HSA-2206292", "R-HSA-2160916", "R-MMU-2160916", "R-RNO-8853383", "R-HSA-9953080", "R-RNO-2024101", "R-HSA-8853383", "R-CEL-8853383", "R-MMU-2024101", "R-MMU-6798695", "R-SSC-2024101", "R-RNO-2160916", "R-RNO-6798695"], "pathways": ["R-HSA-2024101:r:CS/DS degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-2160916:r:Hyaluronan degradation", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-2206292:r:MPS VII - Sly syndrome (Hyaluronan metabolism)", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2160916:r:Hyaluronan degradation", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-9953080:r:MPS VII - Sly syndrome (CS/DS degradation)", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-CEL-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-2024101:r:CS/DS degradation", "R-RNO-2160916:r:Hyaluronan degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036157": {"description": "dUTPase-like superfamily", "go_ids": [], "go_terms": [], "name": "dUTPase-like_sf", "pathway_ids": ["R-HSA-9610379", "R-MMU-499943", "R-HSA-198933", "R-SCE-499943", "R-HSA-9609690", "R-SPO-499943", "R-HSA-499943", "R-DDI-499943", "R-RNO-499943"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9609690:r:HCMV Early Events", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Homologous_superfamily"}, "IPR036161": {"description": "RPB6/omega subunit-like superfamily", "go_ids": ["GO:0006351", "GO:0003677", "GO:0003899"], "go_terms": ["GO:0006351:DNA-templated transcription:P", "GO:0003677:DNA binding:F", "GO:0003899:DNA-directed RNA polymerase activity:F"], "name": "RPB6/omega-like_sf", "pathway_ids": ["R-RNO-6781823", "R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-CEL-72165", "R-DME-76061", "R-MMU-9770562", "R-RNO-73779", "R-HSA-73980", "R-HSA-427413", "R-CEL-72203", "R-DDI-73776", "R-DME-72163", "R-RNO-72163", "R-DDI-6782210", "R-SPO-6781823", "R-DME-75955", "R-DDI-72163", "R-RNO-9018519", "R-HSA-167158", "R-MMU-75955", "R-RNO-73776", "R-MMU-112382", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DME-72203", "R-DME-72086", "R-DDI-674695", "R-CEL-9770562", "R-HSA-76061", "R-MMU-76061", "R-CEL-75953", "R-SPO-6796648", "R-DME-75953", "R-HSA-749476", "R-CEL-73776", "R-DME-6782135", "R-SCE-76061", "R-DME-73762", "R-SPO-9018519", "R-SPO-76066", "R-MMU-72163", "R-HSA-6803529", "R-HSA-167242", "R-CEL-6782210", "R-HSA-8851708", "R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-RNO-76061", "R-CEL-112382", "R-HSA-9670095", "R-HSA-167160", "R-CEL-6782135", "R-DDI-77075", "R-SPO-73779", "R-MMU-73772", "R-MMU-72086", "R-DDI-113418", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-DME-5578749", "R-DME-73779", "R-DME-77075", "R-CEL-73772", "R-DME-9770562", "R-DME-73776", "R-MMU-6781823", "R-HSA-203927", "R-DDI-73772", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-HSA-73780", "R-MMU-73776", "R-DDI-76042", "R-CEL-72163", "R-HSA-167172", "R-SCE-73779", "R-RNO-113418", "R-HSA-76071", "R-DME-113418", "R-HSA-72203", "R-MMU-6796648", "R-RNO-76071", "R-HSA-9770562", "R-CEL-75955", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-SCE-6781823", "R-MMU-76071", "R-RNO-76066", "R-SCE-9018519", "R-HSA-73863", "R-RNO-77075", "R-HSA-167290", "R-SPO-73772", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-DME-76066", "R-CEL-9018519", "R-RNO-9770562", "R-DME-6782210", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-RNO-6807505", "R-MMU-72203", "R-RNO-674695", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-SPO-6807505", "R-RNO-73863", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-RNO-72165", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-SPO-73762", "R-RNO-6782210", "R-SPO-75953", "R-HSA-5601884", "R-SPO-113418", "R-MMU-5250924", "R-CEL-6807505", "R-DME-674695", "R-RNO-72203", "R-RNO-76042", "R-DME-9018519", "R-DDI-73779", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-CEL-113418", "R-DDI-72086", "R-RNO-73762", "R-MMU-674695", "R-MMU-6807505", "R-RNO-5578749", "R-SCE-76042", "R-MMU-9018519", "R-CEL-6781823", "R-SPO-9770562", "R-DME-6807505", "R-DDI-6807505", "R-HSA-167200", "R-SCE-73762", "R-DME-72165", "R-RNO-112382", "R-SCE-674695", "R-MMU-6782210", "R-CEL-6796648", "R-RNO-75953", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-SCE-76066", "R-MMU-73762", "R-MMU-6782135", "R-HSA-76066", "R-HSA-9639775", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-DDI-76061", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-SCE-6782210", "R-HSA-9918481", "R-RNO-6803529", "R-SCE-72203", "R-SCE-6796648", "R-SPO-72203", "R-RNO-72086", "R-SPO-77075", "R-RNO-73772", "R-RNO-6782135", "R-SCE-113418", "R-SCE-72086", "R-MMU-73863", "R-RNO-5250924", "R-HSA-6782135", "R-HSA-73762", "R-CEL-77075", "R-SCE-77075", "R-HSA-5250924", "R-DDI-75953", "R-SPO-6782135", "R-CEL-73762", "R-DME-73772", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-DME-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-72086:r:mRNA Capping", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-73772:r:RNA Polymerase I Promoter Escape", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-76071:r:RNA 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"R-SSC-8957275:r:Post-translational protein phosphorylation", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-114608:r:Platelet degranulation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-114608:r:Platelet degranulation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036177": {"description": "Peptidase M55, D-aminopeptidase superfamily", "go_ids": [], "go_terms": [], "name": "Peptidase_M55_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036178": {"description": "Formimidoyltransferase-cyclodeaminase-like superfamily", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Formintransfe-cycloase-like_sf", "pathway_ids": ["PWY-5030", "PWY-5497", "R-MMU-70921", "R-RNO-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Homologous_superfamily"}, "IPR036179": {"description": "Immunoglobulin-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Ig-like_dom_sf", "pathway_ids": ["R-GGA-388844", "R-HSA-975634", "R-MMU-9856649", "R-MMU-416476", "R-HSA-6798695", "R-HSA-186797", "R-HSA-173623", "R-RNO-9020702", "R-DRE-5654689", "R-MMU-1306955", "R-CEL-6798695", "R-HSA-112411", "R-MMU-2173791", "R-HSA-9669929", "R-BTA-6798695", "R-MMU-4420097", "R-HSA-9670439", "R-SSC-1474228", "R-HSA-190375", "R-HSA-5654693", "R-RNO-190370", "R-MMU-432142", "R-RNO-198203", "R-MMU-445989", "R-RNO-202427", "R-CEL-5654700", "R-MMU-187042", "R-CFA-5673001", "R-HSA-399955", "R-DRE-418990", "R-MMU-2029485", "R-RNO-9013404", "R-SSC-2454202", "R-HSA-9013408", "R-GGA-373920", "R-DME-190372", "R-HSA-5654221", "R-DRE-5654726", "R-MMU-9929356", "R-MMU-1474228", "R-CEL-216083", "R-DRE-1257604", "R-HSA-9706374", "R-HSA-2172127", "R-HSA-9024909", "R-RNO-163125", 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"R-RNO-388844", "R-HSA-389357", "R-DME-416700", "R-MMU-5654712", "R-CEL-6811558", "R-MMU-170984", "R-RNO-5654712", "R-HSA-9680350", "R-HSA-9702620", "R-MMU-5654227", "R-RNO-2172127", "R-RNO-216083", "R-DME-1971475", "R-GGA-1474228", "R-HSA-1251985", "R-RNO-8980692", "R-RNO-1257604", "R-CEL-5654720", "R-DRE-9013404", "R-HSA-8849932", "R-CEL-2024096", "R-DRE-5654221", "R-MMU-173623", "R-RNO-5654719", "R-RNO-416482", "R-RNO-389359", "R-CEL-5654712", "R-MMU-2132295", "R-RNO-3928662", "R-CEL-399956", "R-RNO-6788467", "R-GGA-1433557", "R-CFA-1433557", "R-RNO-2022870", "R-HSA-190372", "R-MMU-5660668", "R-HSA-9706369", "R-HSA-5655332", "R-DME-5654719", "R-HSA-109704", "R-MMU-1227986", "R-HSA-2871809", "R-HSA-6785631", "R-DME-373080", "R-HSA-190371", "R-MMU-1257604", "R-BTA-8849932", "R-RNO-5632681", "R-HSA-110056", "R-HSA-1358803", "R-HSA-9669934", "R-HSA-9034864", "R-MMU-190371", "R-HSA-8853336", "R-MMU-2029481", "R-MMU-389513", "R-DRE-190374", "R-DME-209968", "R-HSA-5173214", "R-RNO-9032759", "R-HSA-8856825", "R-MMU-5654727", "R-CEL-8941413", "R-HSA-9680187", "R-HSA-170968", "R-HSA-428540", "R-RNO-2022854", "R-HSA-9856649", "R-DRE-4420097", "R-BTA-216083", "R-HSA-8853333", "R-HSA-9702518", "R-HSA-391160", "R-MMU-1963640", "R-HSA-3595174", "R-CFA-9856649", "R-MMU-1433559", "R-CEL-2022928", "R-SSC-9020591", "R-MMU-9013106", "R-HSA-8856828", "R-BTA-202424", "R-MMU-9012546", "R-HSA-5654228", "R-MMU-373756", "R-GGA-1227986", "R-HSA-2029481", "R-HSA-9026519", "R-CEL-5673001", "R-MMU-416572", "R-DRE-5673001", "R-CFA-1257604", "R-BTA-5576892", "R-MMU-389357", "R-MMU-5654695", "R-MMU-9706374", "R-CEL-5654732", "R-MMU-381426", "R-MMU-399954", "R-RNO-170968", "R-BTA-2022870", "R-SSC-173623", "R-HSA-9673767", "R-RNO-9013408", "R-HSA-2023837", "R-CEL-5654228", "R-HSA-9007892", "R-DME-6807878", "R-RNO-5673001", "R-MMU-2168880", "R-RNO-3000178", "R-MMU-2022923", "R-DME-5654227", "R-CEL-525793", "R-HSA-373753", "R-HSA-9927354", "R-HSA-447043", "R-HSA-2404192", "R-MMU-1433557", "R-BTA-198933", "R-DME-5654704", "R-MMU-5621575", "R-HSA-210993", "R-MMU-5635838", "R-GGA-216083", "R-RNO-9014826", "R-HSA-166058", "R-HSA-9034793", "R-HSA-451927", "R-MMU-1236977", "R-HSA-9694614", "R-HSA-2029482", "R-SSC-2029485", "R-HSA-9020933", "R-HSA-9673768", "R-HSA-194306", "R-HSA-5218921", "R-MMU-373753", "R-MMU-198933", "R-DRE-5654704", "R-HSA-5635838", "R-MMU-9013406", "R-MMU-420597", "R-MMU-6798695", "R-CEL-186763", "R-BTA-1236974", "R-RNO-376172", "R-MMU-9034013", "R-MMU-416700", "R-RNO-194306", "R-GGA-1306955", "R-HSA-1839128", "R-MMU-114608", "R-DRE-9013423", "R-RNO-432142", "R-HSA-416550", "R-HSA-399956", "R-HSA-167044", "R-DME-419037", "R-DME-5654700", "R-HSA-1300645", "R-HSA-977225", "R-MMU-112411", "R-RNO-1059683", "R-BTA-3000178", "R-RNO-109704", "R-HSA-375165", "R-RNO-2029482", "R-DRE-5654219", "R-HSA-2871837", "R-HSA-210990", "R-MMU-9931295", "R-DRE-2132295", "R-HSA-8877330", "R-GGA-8863795", "R-HSA-416700", "R-CEL-5654706", "R-HSA-5660668", "R-HSA-5621575", "R-CEL-5654699", "R-DRE-9013149", "R-SSC-2029482", "R-DRE-449836", "R-MMU-110056", "R-RNO-1307965", "R-DME-1250347", "R-HSA-525793", "R-BTA-2024101", "R-MMU-5683826", "R-MMU-389948", "R-HSA-1839122", "R-BTA-202430", "R-CEL-210991", "R-HSA-9645135", "R-HSA-445355", "R-HSA-1462054", "R-HSA-373756", "R-HSA-2173791", "R-HSA-5654706", "R-RNO-186797", "R-DME-5654689", "R-HSA-1227986", "R-HSA-1236978", "R-DRE-9856649", "R-SSC-2871837", "R-DRE-1300645", "R-HSA-5654227", "R-DRE-9013148", "R-MMU-1059683", "R-RNO-9007892", "R-DRE-190375", "R-HSA-5627123", "R-CEL-4420097", "R-MMU-9927354", "R-MMU-416482", "R-MMU-5654733", "R-DME-190373", "R-HSA-8957275", "R-DRE-5654695", "R-HSA-9664422", "R-RNO-449836", "R-HSA-9702600", "R-MMU-418885", "R-HSA-9013409", "R-SSC-2730905", "R-RNO-445095", "R-HSA-2243919", "R-MMU-210991", "R-DRE-186797", "R-HSA-3000178", "R-RNO-1474228", "R-HSA-3560783", "R-HSA-9918485", "R-MMU-9013408", "R-HSA-9702596", "R-MMU-210990", "R-CEL-3000178", "R-MMU-210993", "R-SSC-202733", "R-HSA-9856532", "R-HSA-3656237", "R-DME-5654732", "R-RNO-373753", "R-RNO-8863795", "R-BTA-8957275", "R-HSA-9674401", "R-MMU-5632681", "R-DRE-6811558", "R-HSA-9702632", "R-CEL-190373", "R-HSA-166663", "R-HSA-5140745", "R-MMU-5673001", "R-HSA-9701898", "R-MMU-449836", "R-HSA-9669917", "R-HSA-9026527", "R-DME-190370", "R-HSA-9931269", "R-HSA-182971", "R-RNO-1566977", "R-RNO-445144", "R-RNO-1236977", "R-HSA-2424491", "R-SSC-2022857", "R-HSA-9674396", "R-HSA-416482", "R-CFA-983695", "R-DME-433692", "R-MMU-190372", "R-MMU-5690714", "R-HSA-164939", "R-HSA-447041", "R-HSA-164940", "R-HSA-9703009", "R-RNO-5654688", "R-DME-5654695", "R-RNO-879415", "R-SSC-983170", "R-MMU-193648", "R-HSA-9749641", "R-HSA-9793380", "R-HSA-445144", "R-MMU-2730905", "R-HSA-9013026", "R-MMU-2024101", "R-HSA-917977", "R-MMU-5627123", "R-GGA-9749641", "R-BTA-202433", "R-HSA-9664323", "R-BTA-1236977", "R-DME-373752", "R-MMU-416550", "R-CEL-8849932", "R-HSA-5655253", "R-SSC-1236974", "R-DME-1358803", "R-XTR-202433", "R-DME-5673001", "R-HSA-416572", "R-GGA-163125", "R-MMU-8980692", "R-HSA-2029485", "R-HSA-9013106", "R-HSA-373760", "R-MMU-388844", "R-HSA-9013423", "R-DRE-190377", "R-HSA-190374", "R-MMU-190370", "R-CEL-190377", "R-CEL-2243919", "R-CFA-6811558", "R-SSC-2871809", "R-MMU-1250347", "R-CEL-373752", "R-HSA-1250196", "R-HSA-9674404", "R-HSA-2022928", "R-GGA-983170", "R-HSA-9669926", "R-DRE-195399", "R-SSC-2029481", "R-MMU-202424", "R-HSA-389513", "R-GGA-1250196", "R-BTA-8856828", "R-MMU-437239", "R-HSA-5655291", "R-MMU-977606", "R-MMU-109704", "R-DRE-5654227", "R-MMU-391160", "R-RNO-1250342", "R-MMU-9028731", "R-RNO-447043", "R-CFA-6788467", "R-RNO-1227986", "R-MMU-9927353", "R-HSA-376176", "R-MMU-1169091", "R-HSA-5690714", "R-HSA-1236977", "R-SSC-202424", "R-DME-1474228", "R-DME-8941413", "R-MMU-8851680", "R-HSA-9669914", "R-GGA-1250347", "R-HSA-5654219", "R-CEL-5654689", "R-HSA-187024", "R-RNO-399955", "R-MMU-5654689", "R-HSA-9674428", "R-GGA-433692", "R-HSA-9702569", "R-CEL-186797", "R-SSC-198933", "R-GGA-1236394", "R-DME-5654706", "R-GGA-1250342", "R-HSA-8964038", "R-CEL-433692", "R-HSA-182218", "R-CEL-373753", "R-HSA-5654688", "R-MMU-6785631", "R-MMU-163125", "R-MMU-389359", "R-MMU-9607240", "R-RNO-5654726", "R-HSA-187042", "R-MMU-5607764", "R-DRE-399954", "R-MMU-9020933", "R-RNO-9014843", "R-HSA-9927418", "R-RNO-5223345", "R-RNO-9927353", "R-MMU-2243919", "R-RNO-977606", "R-HSA-4420097", "R-MMU-389356", "R-RNO-190373", "R-MMU-3000178", "R-RNO-202733", "R-CEL-1433559", "R-SSC-202433", "R-CEL-190370", "R-RNO-202424", "R-HSA-177929", "R-DRE-5654733", "R-RNO-9034013", "R-HSA-202430", "R-GGA-193634", "R-HSA-5655302", "R-MMU-193634", "R-HSA-381426", "R-SSC-3000178", "R-RNO-389357", "R-DRE-5654720", "R-HSA-2024101", "R-DRE-416572", "R-RNO-5654693", "R-DME-1227986", "R-HSA-9665686", "R-DRE-9007892", "R-HSA-8853334", "R-RNO-198933", "R-HSA-8847993", "R-MMU-8849932", "R-RNO-5658623", "R-GGA-1236974", "R-MMU-5654700", "R-HSA-2033515", "R-GGA-2132286", "R-DRE-190373", "R-RNO-420029", "R-DME-388844", "R-MMU-195399", "R-DRE-5654710", "R-HSA-9013149", "R-DME-5654710", "R-BTA-389948", "R-HSA-8980692", "R-HSA-9014826", "R-HSA-1169091", "R-HSA-3656243", "R-HSA-5654720", "R-MMU-9931269", "R-HSA-4420332", "R-RNO-445989", "R-HSA-418890", "R-HSA-198933", "R-MMU-376172", "R-MMU-1462054", "R-MMU-5654688", "R-RNO-433692", "R-DRE-416482", "R-HSA-5654704", "R-MMU-399956", "R-RNO-9028731", "R-GGA-2132263", "R-MMU-375165", "R-HSA-8853884", "R-CEL-375165", "R-HSA-1307965", "R-MMU-2022870", "R-RNO-420597", "R-SSC-202427", "R-HSA-2122948", "R-HSA-9034015", "R-HSA-3000157", "R-SSC-114608", "R-HSA-9619665", "R-CEL-416700", "R-HSA-416476", "R-CFA-5690714", "R-HSA-5576892", "R-HSA-9032759", "R-DME-6811558", "R-BTA-202733", "R-DRE-5654687", "R-CEL-418885", "R-RNO-8957275", "R-CFA-1433559", "R-HSA-8866910", "R-BTA-381426", "R-MMU-6788467", "R-HSA-5619070", "R-HSA-9833110", "R-MMU-5654228", "R-HSA-195399", "R-RNO-5654687", "R-MMU-5654719", "R-RNO-9013106", "R-HSA-5607764", "R-MMU-1358803", "R-HSA-9028731", "R-HSA-193648", "R-MMU-202433", "R-RNO-210991", "R-RNO-1963640", "R-BTA-2173791", "R-HSA-1566977", "R-DME-77387", "R-DRE-190322", "R-RNO-195399", "R-DME-418990", "R-MMU-2404192", "R-RNO-389356", "R-HSA-1236394", "R-BTA-983170", "R-MMU-418990", "R-HSA-9830674", "R-RNO-5218921", "R-DME-190322", "R-DME-2022928", "R-HSA-9705462", "R-MMU-1236974", "R-MMU-177504", "R-RNO-5654720", "R-MMU-2424491", "R-CFA-983170", "R-DRE-5654688", "R-DRE-416476", "R-CEL-190371", "R-MMU-1971475", "R-RNO-186763", "R-CEL-3000171", "R-CEL-5654704"], "pathways": ["R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-975634:r:Retinoid metabolism and transport", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-RNO-9020702:r:Interleukin-1 signaling", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-187042:r:TRKA activation by NGF", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-418990:r:Adherens junctions interactions", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-SSC-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-9013408:r:RHOG GTPase cycle", "R-GGA-373920:r:Pyruvate metabolism", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-CEL-216083:r:Integrin cell surface interactions", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-HSA-2172127:r:DAP12 interactions", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-373753:r:Nephrin family interactions", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-1462054:r:Alpha-defensins", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-BTA-445355:r:Smooth Muscle Contraction", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SSC-216083:r:Integrin cell surface interactions", "R-HSA-9012546:r:Interleukin-18 signaling", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DRE-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-CEL-419037:r:NCAM1 interactions", "R-CEL-209968:r:Thyroxine biosynthesis", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9702605:r:pexidartinib-resistant FLT3 mutants", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-373760:r:L1CAM interactions", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-1236974:r:ER-Phagosome pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-CFA-216083:r:Integrin cell surface interactions", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8964046:r:VLDL clearance", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-RNO-114608:r:Platelet degranulation", "R-HSA-9702614:r:ponatinib-resistant FLT3 mutants", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-2024101:r:CS/DS degradation", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-HSA-2024096:r:HS-GAG degradation", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-1236977:r:Endosomal/Vacuolar pathway", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-DME-2024096:r:HS-GAG degradation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-SSC-2871796:r:FCERI mediated MAPK activation", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-9020591:r:Interleukin-12 signaling", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-390522:r:Striated Muscle Contraction", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-CEL-445144:r:Signal transduction by L1", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SSC-2424491:r:DAP12 signaling", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-SSC-977606:r:Regulation of Complement cascade", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-DME-447043:r:Neurofascin interactions", "R-RNO-2424491:r:DAP12 signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-1236394:r:Signaling by ERBB4", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-SSC-5690714:r:CD22 mediated BCR regulation", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-GGA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-202433:r:Generation of second messenger molecules", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-RNO-525793:r:Myogenesis", "R-GGA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-447038:r:NrCAM interactions", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-77387:r:Insulin receptor recycling", "R-MMU-9007892:r:Interleukin-38 signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-SSC-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-RNO-2029481:r:FCGR activation", "R-DME-114608:r:Platelet degranulation", "R-SSC-432142:r:Platelet sensitization by LDL", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-CEL-447043:r:Neurofascin interactions", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-HSA-9702590:r:gilteritinib-resistant FLT3 mutants", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-420029:r:Tight junction interactions", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-433692:r:Proton-coupled monocarboxylate transport", "R-RNO-8951664:r:Neddylation", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SSC-389948:r:Co-inhibition by PD-1", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-77387:r:Insulin receptor recycling", "R-MMU-186797:r:Signaling by PDGF", "R-BTA-2424491:r:DAP12 signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-9020956:r:Interleukin-27 signaling", "R-MMU-2172127:r:DAP12 interactions", "R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-RNO-190322:r:FGFR4 ligand binding and activation", "R-SSC-2168880:r:Scavenging of heme from plasma", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8951664:r:Neddylation", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-198745:r:Signalling to STAT3", "R-MMU-9014843:r:Interleukin-33 signaling", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-DME-3000178:r:ECM proteoglycans", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-SSC-9020933:r:Interleukin-23 signaling", "R-SSC-2132295:r:MHC class II antigen presentation", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9702577:r:semaxanib-resistant FLT3 mutants", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-RNO-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-9702509:r:FLT3 mutants bind TKIs", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-DRE-186763:r:Downstream signal transduction", "R-HSA-373752:r:Netrin-1 signaling", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-389356:r:Co-stimulation by CD28", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9702581:r:crenolanib-resistant FLT3 mutants", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-GGA-3000178:r:ECM proteoglycans", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-DRE-109704:r:PI3K Cascade", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-GGA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-HSA-114608:r:Platelet degranulation", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-9020591:r:Interleukin-12 signaling", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-XTR-418990:r:Adherens junctions interactions", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-CEL-9749641:r:Aspirin ADME", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9014843:r:Interleukin-33 signaling", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-SSC-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-MMU-2022857:r:Keratan sulfate degradation", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-BTA-210993:r:Tie2 Signaling", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-DRE-193648:r:NRAGE signals death through JNK", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9702636:r:tandutinib-resistant FLT3 mutants", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-1307965:r:betaKlotho-mediated ligand binding", "R-DME-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-DME-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-BTA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-DME-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-GGA-210991:r:Basigin interactions", "R-MMU-447043:r:Neurofascin interactions", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-SSC-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-419037:r:NCAM1 interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-373760:r:L1CAM interactions", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-182971:r:EGFR downregulation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-432142:r:Platelet sensitization by LDL", "R-DME-190371:r:FGFR3b ligand binding and activation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DRE-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-DME-9749641:r:Aspirin ADME", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-DME-1307965:r:betaKlotho-mediated ligand binding", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-MMU-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-CEL-190322:r:FGFR4 ligand binding and activation", "R-DRE-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-420029:r:Tight junction interactions", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-DME-1236394:r:Signaling by ERBB4", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-1433559:r:Regulation of KIT signaling", "R-GGA-6798695:r:Neutrophil degranulation", "R-DRE-210993:r:Tie2 Signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-BTA-5690714:r:CD22 mediated BCR regulation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-RNO-77387:r:Insulin receptor recycling", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9620244:r:Long-term potentiation", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-9702998:r:linifanib-resistant FLT3 mutants", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-376172:r:DSCAM interactions", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-419037:r:NCAM1 interactions", "R-HSA-9669933:r:Signaling by kinase domain mutants of KIT", "R-DRE-190370:r:FGFR1b ligand binding and activation", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-RNO-418990:r:Adherens junctions interactions", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-977443:r:GABA receptor activation", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-BTA-114608:r:Platelet degranulation", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-RNO-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9014826:r:Interleukin-36 pathway", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-373752:r:Netrin-1 signaling", "R-HSA-420597:r:Nectin/Necl trans heterodimerization", "R-RNO-170984:r:ARMS-mediated activation", "R-DME-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-DRE-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-376172:r:DSCAM interactions", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-4086400:r:PCP/CE pathway", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-GGA-1433559:r:Regulation of KIT signaling", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DME-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-9749641:r:Aspirin ADME", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-DME-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-HSA-9702624:r:sorafenib-resistant FLT3 mutants", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-433692:r:Proton-coupled monocarboxylate transport", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-420029:r:Tight junction interactions", "R-DRE-202733:r:Cell surface interactions at the vascular wall", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-DRE-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-418990:r:Adherens junctions interactions", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-5632681:r:Ligand-receptor interactions", "R-SSC-210990:r:PECAM1 interactions", "R-DRE-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-1236394:r:Signaling by ERBB4", "R-DRE-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-210991:r:Basigin interactions", "R-HSA-170984:r:ARMS-mediated activation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CEL-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-MMU-9035034:r:RHOF GTPase cycle", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-210991:r:Basigin interactions", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-437239:r:Recycling pathway of L1", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DRE-216083:r:Integrin cell surface interactions", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-416700:r:Other semaphorin interactions", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-170984:r:ARMS-mediated activation", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-9702620:r:quizartinib-resistant FLT3 mutants", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-2172127:r:DAP12 interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-DME-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-2024096:r:HS-GAG degradation", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-2132295:r:MHC class II antigen presentation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-MMU-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-9706369:r:Negative regulation of FLT3", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-209968:r:Thyroxine biosynthesis", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-SSC-9020591:r:Interleukin-12 signaling", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-9012546:r:Interleukin-18 signaling", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-373756:r:SDK interactions", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-2029481:r:FCGR activation", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-170968:r:Frs2-mediated activation", "R-BTA-2022870:r:CS-GAG biosynthesis", "R-SSC-173623:r:Classical antibody-mediated complement activation", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9007892:r:Interleukin-38 signaling", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-CEL-525793:r:Myogenesis", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-210993:r:Tie2 Signaling", "R-MMU-5635838:r:Activation of SMO", "R-GGA-216083:r:Integrin cell surface interactions", "R-RNO-9014826:r:Interleukin-36 pathway", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-451927:r:Interleukin-2 family signaling", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SSC-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9020933:r:Interleukin-23 signaling", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-5635838:r:Activation of SMO", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-420597:r:Nectin/Necl trans heterodimerization", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-1236974:r:ER-Phagosome pathway", "R-RNO-376172:r:DSCAM interactions", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-MMU-416700:r:Other semaphorin interactions", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-GGA-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-MMU-114608:r:Platelet degranulation", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-RNO-432142:r:Platelet sensitization by LDL", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-167044:r:Signalling to RAS", "R-DME-419037:r:NCAM1 interactions", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-BTA-3000178:r:ECM proteoglycans", "R-RNO-109704:r:PI3K Cascade", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DRE-2132295:r:MHC class II antigen presentation", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-416700:r:Other semaphorin interactions", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-449836:r:Other interleukin signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-525793:r:Myogenesis", "R-BTA-2024101:r:CS/DS degradation", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-389948:r:Co-inhibition by PD-1", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-BTA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-CEL-210991:r:Basigin interactions", "R-HSA-9645135:r:STAT5 Activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-1462054:r:Alpha-defensins", "R-HSA-373756:r:SDK interactions", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-186797:r:Signaling by PDGF", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-DRE-1300645:r:Acrosome Reaction and Sperm:Oocyte Membrane Binding", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-9007892:r:Interleukin-38 signaling", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-9702600:r:midostaurin-resistant FLT3 mutants", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SSC-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-MMU-210991:r:Basigin interactions", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9702596:r:lestaurtinib-resistant FLT3 mutants", "R-MMU-210990:r:PECAM1 interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-MMU-210993:r:Tie2 Signaling", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-373753:r:Nephrin family interactions", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-MMU-5632681:r:Ligand-receptor interactions", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9702632:r:sunitinib-resistant FLT3 mutants", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-182971:r:EGFR downregulation", "R-RNO-1566977:r:Fibronectin matrix formation", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-2424491:r:DAP12 signaling", "R-SSC-2022857:r:Keratan sulfate degradation", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CFA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-164939:r:Nef mediated downregulation of CD28 cell surface expression", "R-HSA-447041:r:CHL1 interactions", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-HSA-9703009:r:tamatinib-resistant FLT3 mutants", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-SSC-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9749641:r:Aspirin ADME", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-GGA-9749641:r:Aspirin ADME", "R-BTA-202433:r:Generation of second messenger molecules", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-BTA-1236977:r:Endosomal/Vacuolar pathway", "R-DME-373752:r:Netrin-1 signaling", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-SSC-1236974:r:ER-Phagosome pathway", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-XTR-202433:r:Generation of second messenger molecules", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-373760:r:L1CAM interactions", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-373752:r:Netrin-1 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-9674404:r:Sorafenib-resistant PDGFR mutants", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-GGA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9669926:r:Nilotinib-resistant KIT mutants", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-SSC-2029481:r:FCGR activation", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-GGA-1250196:r:SHC1 events in ERBB2 signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-977606:r:Regulation of Complement cascade", "R-MMU-109704:r:PI3K Cascade", "R-DRE-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-RNO-447043:r:Neurofascin interactions", "R-CFA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-HSA-376176:r:Signaling by ROBO receptors", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-SSC-202424:r:Downstream TCR signaling", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-HSA-187024:r:NGF-independant TRKA activation", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-GGA-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-9702569:r:KW2449-resistant FLT3 mutants", "R-CEL-186797:r:Signaling by PDGF", "R-SSC-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-GGA-1236394:r:Signaling by ERBB4", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-GGA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-8964038:r:LDL clearance", "R-CEL-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-CEL-373753:r:Nephrin family interactions", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-187042:r:TRKA activation by NGF", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-9020933:r:Interleukin-23 signaling", "R-RNO-9014843:r:Interleukin-33 signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-RNO-9927353:r:Co-inhibition by BTLA", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-1433559:r:Regulation of KIT signaling", "R-SSC-202433:r:Generation of second messenger molecules", "R-CEL-190370:r:FGFR1b ligand binding and activation", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-177929:r:Signaling by EGFR", "R-DRE-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-GGA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-DRE-5654720:r:PI-3K cascade:FGFR4", "R-HSA-2024101:r:CS/DS degradation", "R-DRE-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DRE-9007892:r:Interleukin-38 signaling", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-RNO-5658623:r:FGFRL1 modulation of FGFR1 signaling", "R-GGA-1236974:r:ER-Phagosome pathway", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", "R-GGA-2132286:r:Classical antibody-mediated complement activation", "R-DRE-190373:r:FGFR1c ligand binding and activation", "R-RNO-420029:r:Tight junction interactions", "R-DME-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DRE-5654710:r:PI-3K cascade:FGFR3", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9014826:r:Interleukin-36 pathway", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-376172:r:DSCAM interactions", "R-MMU-1462054:r:Alpha-defensins", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-433692:r:Proton-coupled monocarboxylate transport", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1307965:r:betaKlotho-mediated ligand binding", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-RNO-420597:r:Nectin/Necl trans heterodimerization", "R-SSC-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-HSA-3000157:r:Laminin interactions", "R-SSC-114608:r:Platelet degranulation", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-416700:r:Other semaphorin interactions", "R-HSA-416476:r:G alpha (q) signalling events", "R-CFA-5690714:r:CD22 mediated BCR regulation", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654687:r:Downstream signaling of activated FGFR1", "R-CEL-418885:r:DCC mediated attractive signaling", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-CFA-1433559:r:Regulation of KIT signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-5619070:r:Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-RNO-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-202433:r:Generation of second messenger molecules", "R-RNO-210991:r:Basigin interactions", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-1566977:r:Fibronectin matrix formation", "R-DME-77387:r:Insulin receptor recycling", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-DME-418990:r:Adherens junctions interactions", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-RNO-389356:r:Co-stimulation by CD28", "R-HSA-1236394:r:Signaling by ERBB4", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-9830674:r:Formation of the ureteric bud", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-DME-2022928:r:HS-GAG biosynthesis", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-1236974:r:ER-Phagosome pathway", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-CFA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-416476:r:G alpha (q) signalling events", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-186763:r:Downstream signal transduction", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3"], "type": "Homologous_superfamily"}, "IPR036180": {"description": "Gelsolin-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Gelsolin-like_dom_sf", "pathway_ids": ["R-HSA-1655829", "R-MMU-204005", "R-DDI-983170", "R-HSA-2132295", "R-XTR-204005", "R-DDI-204005", "R-HSA-9705671", "R-DDI-5694530", "R-DME-6798695", "R-MMU-5694530", "R-DRE-204005", "R-SCE-204005", "R-SPO-204005", "R-XTR-5694530", "R-SPO-5694530", "R-DRE-5694530", "R-DRE-983170", "R-HSA-5694530", "R-BTA-983170", "R-HSA-204005", "R-HSA-983170", "R-DRE-2132295", "R-SCE-5694530", "R-BTA-5694530", "R-MMU-2132295", "R-MMU-983170", "R-DME-264870", "R-BTA-204005", "R-BTA-2132295", "R-SPO-983170", "R-SCE-983170"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-2132295:r:MHC class II antigen presentation", "R-XTR-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-5694530:r:Cargo concentration in the ER", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-5694530:r:Cargo concentration in the ER", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-XTR-5694530:r:Cargo concentration in the ER", "R-SPO-5694530:r:Cargo concentration in the ER", "R-DRE-5694530:r:Cargo concentration in the ER", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-2132295:r:MHC class II antigen presentation", "R-SCE-5694530:r:Cargo concentration in the ER", "R-BTA-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "type": "Homologous_superfamily"}, "IPR036181": {"description": "MIT domain superfamily", "go_ids": [], "go_terms": [], "name": "MIT_dom_sf", "pathway_ids": ["R-BTA-983168", "R-RNO-917729", "R-BTA-8951664", "R-RNO-5632684", "R-MMU-1474228", "R-MMU-5632684", "R-HSA-1474228", "R-HSA-9610379", "R-MMU-917729", "R-BTA-917729", "R-MMU-9668328", "R-HSA-8951664", "R-DRE-8951664", "R-HSA-983168", "R-HSA-162588", "R-HSA-5632684", "R-HSA-9668328", "R-DRE-983168", "R-HSA-917729", "R-MMU-8951664", "R-SPO-9668328", "R-SCE-9668328", "R-RNO-8951664", "R-MMU-983168", "R-XTR-9668328", "R-DDI-917729", "R-RNO-983168", "R-DDI-9668328", "R-RNO-9668328"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-8951664:r:Neddylation", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-1474228:r:Degradation 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"IBP39-like_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036185": {"description": "DNA helicase, DnaB-like, N-terminal domain superfamily", "go_ids": ["GO:0006260", "GO:0005524", "GO:0003678"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0005524:ATP binding:F", "GO:0003678:DNA helicase activity:F"], "name": "DNA_heli_DnaB-like_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036186": {"description": "Serpin superfamily", "go_ids": [], "go_terms": [], "name": "Serpin_sf", "pathway_ids": ["R-HSA-6798695", "R-MMU-416476", "R-HSA-1989781", "R-MMU-204005", "R-GGA-8939242", "R-HSA-3000178", "R-HSA-140837", "R-MMU-5694530", "R-RNO-140875", "R-BTA-6798695", "R-BTA-9757110", "R-MMU-375276", "R-HSA-9686347", "R-HSA-1368108", "R-HSA-5694530", "R-MMU-8957275", "R-HSA-1650814", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-BTA-418594", "R-BTA-9948001", "R-MMU-3000178", "R-MMU-381426", "R-HSA-9926550", "R-DME-140875", 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transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-9948001:r:CASP4 inflammasome assembly", "R-BTA-5694530:r:Cargo concentration in the ER", "R-DME-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-DME-9757110:r:Prednisone ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation", "R-MMU-9757110:r:Prednisone ADME", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DME-194002:r:Glucocorticoid biosynthesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-9757110:r:Prednisone ADME", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-SSC-114608:r:Platelet degranulation", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-9757110:r:Prednisone ADME", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-DME-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-5694530:r:Cargo concentration in the ER", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-SSC-75205:r:Dissolution of Fibrin Clot", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-194002:r:Glucocorticoid biosynthesis", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-9948001:r:CASP4 inflammasome assembly", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-HSA-194002:r:Glucocorticoid biosynthesis"], "type": "Homologous_superfamily"}, "IPR036187": {"description": "DNA mismatch repair protein MutS, core domain superfamily", "go_ids": [], "go_terms": [], "name": "DNA_mismatch_repair_MutS_sf", "pathway_ids": ["R-BTA-5358606", "R-RNO-5358565", "R-SPO-5358565", "R-HSA-5632927", "R-HSA-5358606", "R-DDI-5358565", "R-SCE-5358606", "R-HSA-6796648", "R-DME-5358565", "R-HSA-5632928", "R-HSA-5632968", "R-BTA-5358565", "R-SCE-5358565", "R-HSA-912446", "R-SPO-5358606", "R-HSA-5358565", "R-MMU-5358606", "R-MMU-5358565"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "type": "Homologous_superfamily"}, "IPR036188": {"description": "FAD/NAD(P)-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "FAD/NAD-bd_sf", "pathway_ids": ["R-HSA-71240", "R-SCE-9969896", "R-CEL-71064", "R-HSA-6799198", "R-MMU-181430", "R-HSA-5263617", "R-RNO-9018519", "R-RNO-3299685", "R-DDI-189451", "R-RNO-3214842", "R-DME-9854311", "R-CEL-71403", "R-BTA-9859138", "R-HSA-5579012", "R-DDI-9854311", "R-SPO-2142789", "R-HSA-3299685", "R-HSA-196108", "R-HSA-6798163", "R-SPO-71064", "R-DME-5625886", "R-CEL-5362517", "R-HSA-196807", "R-HSA-5579026", "R-BTA-2142789", "R-RNO-9858328", "R-BTA-5628897", "R-MMU-204174", "R-RNO-9764725", "R-RNO-2395516", "R-MMU-211976", "R-HSA-379401", "R-DDI-2142789", "R-DRE-380612", "R-BTA-189451", "R-RNO-5362517", 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to Ferredoxin", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9907570:r:Loss-of-function mutations in DLD cause MSUD3/DLDD", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-73621:r:Pyrimidine catabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-RNO-163560:r:Triglyceride catabolism", "R-MMU-1483166:r:Synthesis of PA", "R-RNO-611105:r:Respiratory electron transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-MTU-870331:r:Mycothiol metabolism", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-DDI-8964208:r:Phenylalanine metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-XTR-71403:r:Citric acid cycle (TCA 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"R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-CEL-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-SPO-9969896:r:Lanosterol biosynthesis", "R-CEL-163560:r:Triglyceride catabolism", "R-MMU-71064:r:Lysine catabolism", "R-MMU-6783984:r:Glycine degradation", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-189451:r:Heme biosynthesis", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DME-8873719:r:RAB geranylgeranylation", "R-RNO-1614558:r:Degradation of cysteine and homocysteine", "R-CEL-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-3214842:r:HDMs demethylate histones", "R-DDI-71240:r:Tryptophan catabolism", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-MMU-8873719:r:RAB geranylgeranylation", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-611105:r:Respiratory electron transport", "R-DME-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-CEL-8873719:r:RAB geranylgeranylation", "R-DRE-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-SPO-2395516:r:Electron transport from NADPH to Ferredoxin", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-SPO-611105:r:Respiratory electron transport", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-SPO-163560:r:Triglyceride catabolism", "R-RNO-380612:r:Metabolism of serotonin", "R-SSC-1614558:r:Degradation of cysteine and homocysteine", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-BTA-380612:r:Metabolism of serotonin", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-CEL-6783984:r:Glycine degradation", "R-HSA-351200:r:Interconversion of polyamines", "R-HSA-3214815:r:HDACs deacetylate histones", "R-DRE-379401:r:Dopamine clearance from the synaptic cleft", "R-MMU-141334:r:PAOs oxidise polyamines to amines", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-2142789:r:Ubiquinol biosynthesis", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-HSA-379398:r:Enzymatic degradation of Dopamine by monoamine oxidase", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-MMU-1614558:r:Degradation of cysteine and homocysteine", "R-CEL-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-RNO-5263617:r:Metabolism of ingested MeSeO2H into MeSeH", "R-RNO-211976:r:Endogenous sterols", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5579019:r:Defective FMO3 causes TMAU", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-2395516:r:Electron transport from NADPH to Ferredoxin", "R-MMU-196807:r:Nicotinate metabolism", "R-DDI-611105:r:Respiratory electron transport", "R-HSA-8873719:r:RAB geranylgeranylation", "R-HSA-1614517:r:Sulfide oxidation to sulfate", "R-SCE-8873719:r:RAB geranylgeranylation", "R-HSA-217271:r:FMO oxidises nucleophiles", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-3214815:r:HDACs deacetylate histones", "R-DDI-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-DRE-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SPO-1483166:r:Synthesis of PA", "R-MMU-3214842:r:HDMs demethylate histones", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5689603:r:UCH proteinases", "R-CEL-3214842:r:HDMs demethylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-71240:r:Tryptophan catabolism", "R-CEL-2142789:r:Ubiquinol biosynthesis", "R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-71240:r:Tryptophan catabolism", "R-HSA-2395516:r:Electron transport from NADPH to Ferredoxin", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-163560:r:Triglyceride catabolism", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-163560:r:Triglyceride catabolism", "R-MMU-8964208:r:Phenylalanine metabolism", "R-BTA-141333:r:Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "R-RNO-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-379397:r:Enzymatic degradation of dopamine by COMT", "R-CFA-1614558:r:Degradation of cysteine and homocysteine", "R-RNO-8873719:r:RAB geranylgeranylation", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-1483166:r:Synthesis of PA", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SCE-611105:r:Respiratory electron transport", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species"], "type": "Homologous_superfamily"}, "IPR036189": {"description": "mRNA decapping protein 2, Box A domain superfamily", "go_ids": ["GO:0016787", "GO:0030145", "GO:0003723"], "go_terms": ["GO:0016787:hydrolase activity:F", "GO:0030145:manganese ion binding:F", "GO:0003723:RNA binding:F"], "name": "DCP2_BoxA_sf", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-HSA-380994", "R-MMU-450513", "R-MMU-430039", "R-MMU-450604", "R-CEL-450385", "R-HSA-450513", "R-SCE-450513", "R-HSA-450604", "R-SCE-430039", "R-CEL-430039", "R-CEL-450513", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Homologous_superfamily"}, "IPR036190": {"description": "Urocanase superfamily", "go_ids": [], "go_terms": [], "name": "Urocanase_sf", "pathway_ids": ["PWY-5030", "PWY-5028", "R-MMU-70921", "R-CEL-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5028:t:L-histidine degradation II", "R-MMU-70921:r:Histidine catabolism", "R-CEL-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Homologous_superfamily"}, "IPR036191": {"description": "RRF superfamily", "go_ids": [], "go_terms": [], "name": "RRF_sf", "pathway_ids": ["R-RNO-5419276", "R-CEL-5419276", "R-MMU-5419276", "R-HSA-5419276"], "pathways": ["R-RNO-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-5419276:r:Mitochondrial translation termination"], "type": "Homologous_superfamily"}, "IPR036192": {"description": "Cell division protein ZapA-like superfamily", "go_ids": [], "go_terms": [], "name": "Cell_div_ZapA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036193": {"description": "Adenylate kinase, active site lid domain superfamily", "go_ids": ["GO:0004017"], "go_terms": ["GO:0004017:AMP kinase activity:F"], "name": "ADK_active_lid_dom_sf", "pathway_ids": ["PWY-7219", "R-CEL-983231", "R-DRE-499943", "R-DME-499943", "R-SSC-499943", "R-DDI-983231", "R-RNO-983231", "R-RNO-499943", "R-BTA-499943", "R-CEL-499943", "R-DME-983231", "R-HSA-983231", "R-MMU-983231", "R-HSA-499943", "R-BTA-983231", "R-MMU-499943", "R-DDI-499943"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SSC-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Homologous_superfamily"}, "IPR036194": {"description": "Flagellar transcriptional activator FlhD superfamily", "go_ids": [], "go_terms": [], "name": "FlhD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036195": {"description": "Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily", "go_ids": ["GO:0046373", "GO:0046556"], "go_terms": ["GO:0046373:L-arabinose metabolic process:P", "GO:0046556:alpha-L-arabinofuranosidase activity:F"], "name": "AbfB_ABD_sf", "pathway_ids": ["R-HSA-9662361"], "pathways": ["R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Homologous_superfamily"}, "IPR036196": {"description": "Phosphotyrosine protein phosphatase I superfamily", "go_ids": [], "go_terms": [], "name": "Ptyr_pPase_sf", "pathway_ids": ["R-HSA-9636383", "R-HSA-9637628", "R-HSA-9636467", "R-HSA-9635465"], "pathways": ["R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-HSA-9636467:r:Blockage of phagosome acidification", "R-HSA-9635465:r:Suppression of apoptosis"], "type": "Homologous_superfamily"}, "IPR036197": {"description": "NarG-like superfamily", "go_ids": [], "go_terms": [], "name": "NarG-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036198": {"description": "Ecotin superfamily", "go_ids": [], "go_terms": [], "name": "Ecotin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036199": {"description": "Portal protein Gp10 superfamily", "go_ids": [], "go_terms": [], "name": "Gp10_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036200": {"description": "Attachment protein G3P, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Attachment_G3P_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036201": {"description": "Pacifastin domain superfamily", "go_ids": ["GO:0030414"], "go_terms": ["GO:0030414:peptidase inhibitor activity:F"], "name": "Pacifastin_dom_sf", "pathway_ids": ["R-HSA-5083635", "R-HSA-5173214"], "pathways": ["R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Homologous_superfamily"}, "IPR036202": {"description": "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily", "go_ids": ["GO:0006265", "GO:0003677", "GO:0003917", "GO:0005694"], "go_terms": ["GO:0006265:DNA topological change:P", "GO:0003677:DNA binding:F", "GO:0003917:DNA topoisomerase type I (single strand cut, ATP-independent) activity:F", "GO:0005694:chromosome:C"], "name": "TopoI_DNA-bd_euk_N_sf", "pathway_ids": ["R-RNO-4615885", "R-SCE-4615885", "R-HSA-4615885", "R-SPO-4615885", "R-MMU-4615885", "R-CEL-4615885", "R-DDI-4615885"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SCE-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-4615885:r:SUMOylation of DNA replication proteins", "R-DDI-4615885:r:SUMOylation of DNA replication proteins"], "type": "Homologous_superfamily"}, "IPR036203": {"description": "Poliovirus core protein 3a, soluble domain", "go_ids": [], "go_terms": [], "name": "P3A_soluble_dom", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Homologous_superfamily"}, "IPR036204": {"description": "ATP synthase-coupling factor 6 superfamily, mitochondrial", "go_ids": ["GO:0045259", "GO:0015986", "GO:0015078"], "go_terms": ["GO:0045259:proton-transporting ATP synthase complex:C", "GO:0015986:proton motive force-driven ATP synthesis:P", "GO:0015078:proton transmembrane transporter activity:F"], "name": "ATP_synth_f6_sf_mt", "pathway_ids": ["R-MMU-9837999", "R-BTA-8949613", "R-BTA-9837999", "R-DME-9837999", "R-MMU-163210", "R-DME-8949613", "R-BTA-163210", "R-HSA-9837999", "R-RNO-163210", "R-DME-163210", "R-RNO-8949613", "R-RNO-9837999", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-8949613:r:Cristae formation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-8949613:r:Cristae formation", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Homologous_superfamily"}, "IPR036206": {"description": "Thiamin phosphate synthase superfamily", "go_ids": [], "go_terms": [], "name": "ThiamineP_synth_sf", "pathway_ids": ["PWY-8457", "PWY-6894", "PWY-6908", "PWY-6907", "PWY-7356", "PWY-6897", "PWY-6893"], "pathways": ["PWY-8457:t:thiamine diphosphate salvage V", "PWY-6894:t:thiamine diphosphate biosynthesis I (E. coli)", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "PWY-6897:t:thiamine diphosphate salvage II", "PWY-6893:t:thiamine diphosphate biosynthesis II (Bacillus)"], "type": "Homologous_superfamily"}, "IPR036207": {"description": "B-form DNA mimic Ocr", "go_ids": [], "go_terms": [], "name": "B-form_Ocr", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036208": {"description": "VHL superfamily", "go_ids": [], "go_terms": [], "name": "VHL_sf", "pathway_ids": ["R-RNO-1234176", "R-DME-983168", "R-MMU-3232142", "R-HSA-9694686", "R-HSA-9706019", "R-HSA-8951664", "R-DME-8951664", "R-RNO-9706019", "R-HSA-9682706", "R-MMU-9706019", "R-HSA-983168", "R-CEL-983168", "R-MMU-1234176", "R-HSA-3232142", "R-MMU-8951664", "R-CEL-1234176", "R-CEL-3232142", "R-RNO-8951664", "R-MMU-983168", "R-RNO-3232142", "R-DME-1234176", "R-RNO-983168", "R-CEL-8951664", "R-HSA-1234176"], "pathways": ["R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-8951664:r:Neddylation", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Homologous_superfamily"}, "IPR036209": {"description": "Sporulation protein SpoIIT-like", "go_ids": [], "go_terms": [], "name": "SpoIIT-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036211": {"description": "eIF4G, eIF4e-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "eIF4G_eIF4E-bd_sf", "pathway_ids": ["R-SPO-975956", "R-SCE-156827", "R-SCE-72649", "R-SPO-72662", "R-SCE-975957", "R-SPO-72702", "R-SPO-72706", "R-SPO-72649", "R-SCE-975956", "R-SCE-72662", "R-SPO-156827", "R-SCE-166208", "R-SPO-975957", "R-SPO-166208", "R-SPO-429947", "R-SCE-72702", "R-SCE-429947"], "pathways": ["R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72649:r:Translation initiation complex formation", "R-SPO-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-72662:r:Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-166208:r:mTORC1-mediated signalling", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-166208:r:mTORC1-mediated signalling", "R-SPO-429947:r:Deadenylation of mRNA", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-429947:r:Deadenylation of mRNA"], "type": "Homologous_superfamily"}, "IPR036212": {"description": "Bromelain inhibitor VI superfamily", "go_ids": [], "go_terms": [], "name": "Bromein_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036213": {"description": "Calpain large subunit, domain III superfamily", "go_ids": [], "go_terms": [], "name": "Calpain_III_sf", "pathway_ids": ["R-HSA-1474228", "R-HSA-6798695", "R-RNO-6798695", "R-DDI-6798695", "R-SSC-6798695", "R-HSA-6809371", "R-MMU-9856530", "R-DME-6798695", "R-RNO-1474228", "R-CEL-6798695", "R-BTA-1474228", "R-HSA-8862803", "R-SSC-1474228", "R-RNO-9860927", "R-RNO-9856530", "R-BTA-9860927", "R-SSC-6809371", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-9856530", "R-BTA-9856530", "R-MMU-9860927", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SSC-6809371:r:Formation of the cornified envelope", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Homologous_superfamily"}, "IPR036214": {"description": "Baseplate structural protein Gp11 superfamily", "go_ids": [], "go_terms": [], "name": "Gp11_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036215": {"description": "TM0957-like superfamily", "go_ids": [], "go_terms": [], "name": "TM0957-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036216": {"description": "Putative type 4B encapsulin shell protein superfamily", "go_ids": [], "go_terms": [], "name": "ENCP4_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036217": {"description": "Methylated DNA-protein cysteine methyltransferase, DNA binding domain", "go_ids": [], "go_terms": [], "name": "MethylDNA_cys_MeTrfase_DNAb", "pathway_ids": ["R-HSA-5657655"], "pathways": ["R-HSA-5657655:r:MGMT-mediated DNA damage reversal"], "type": "Homologous_superfamily"}, "IPR036218": {"description": "HIV integrase-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "HIVI-bd_sf", "pathway_ids": ["R-BTA-9772755", "R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-9772755", "R-RNO-9772755", "R-HSA-175567", "R-MMU-9772755", "R-HSA-180689", "R-HSA-164843"], "pathways": ["R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation"], "type": "Homologous_superfamily"}, "IPR036219": {"description": "Translation elongation factor eEF-1beta-like superfamily", "go_ids": [], "go_terms": [], "name": "eEF-1beta-like_sf", "pathway_ids": ["R-MMU-156842", "R-SSC-156842", "R-BTA-156842", "R-RNO-156842", "R-HSA-156842", "R-XTR-156842", "R-SCE-156842", "R-DME-156842", "R-DDI-156842", "R-SPO-156842"], "pathways": ["R-MMU-156842:r:Eukaryotic Translation Elongation", "R-SSC-156842:r:Eukaryotic Translation Elongation", "R-BTA-156842:r:Eukaryotic Translation Elongation", "R-RNO-156842:r:Eukaryotic Translation Elongation", "R-HSA-156842:r:Eukaryotic Translation Elongation", "R-XTR-156842:r:Eukaryotic Translation Elongation", "R-SCE-156842:r:Eukaryotic Translation Elongation", "R-DME-156842:r:Eukaryotic Translation Elongation", "R-DDI-156842:r:Eukaryotic Translation Elongation", "R-SPO-156842:r:Eukaryotic Translation Elongation"], "type": "Homologous_superfamily"}, "IPR036220": {"description": "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "UDP-Glc/GDP-Man_DH_C_sf", "pathway_ids": ["PWY-7346", "PWY-7820", "R-BTA-173599", "R-HSA-173599", "R-CEL-173599", "R-RNO-173599", "R-MMU-173599", "R-DME-173599"], "pathways": ["PWY-7346:t:UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "R-BTA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-CEL-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-RNO-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DME-173599:r:Formation of the active cofactor, UDP-glucuronate"], "type": "Homologous_superfamily"}, "IPR036222": {"description": "Adenylate cyclase-associated CAP, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CAP_N_sf", "pathway_ids": ["R-DDI-6798695", "R-HSA-114608", "R-SPO-6798695", "R-HSA-6798695", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-428890", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036223": {"description": "Adenylate cyclase-associated CAP, C-terminal superfamily", "go_ids": [], "go_terms": [], "name": "CAP_C_sf", "pathway_ids": ["R-DDI-6798695", "R-HSA-114608", "R-SPO-6798695", "R-HSA-6798695", "R-DRE-5624138", "R-MMU-5624138", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-5624138", "R-HSA-428890", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036224": {"description": "GINS, helical bundle-like domain superfamily", "go_ids": [], "go_terms": [], "name": "GINS_bundle-like_dom_sf", "pathway_ids": ["R-BTA-176974", "R-DME-176974", "R-HSA-176974", "R-CEL-176974", "R-RNO-176974", "R-SPO-176974", "R-DDI-176974", "R-MMU-176974", "R-SCE-176974"], "pathways": ["R-BTA-176974:r:Unwinding of DNA", "R-DME-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-CEL-176974:r:Unwinding of DNA", "R-RNO-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA"], "type": "Homologous_superfamily"}, "IPR036225": {"description": "SRP/SRP receptor, N-terminal", "go_ids": [], "go_terms": [], "name": "SRP/SRP_N", "pathway_ids": ["R-HSA-1799339", "R-HSA-381038", "R-CFA-1799339", "R-DDI-1799339", "R-BTA-1799339", "R-SCE-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Homologous_superfamily"}, "IPR036226": {"description": "Lipoxigenase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "LipOase_C_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-2142691", "R-HSA-2142700", "R-HSA-9018676", "R-RNO-9023661", "R-MMU-9027604", "R-RNO-2142688", "R-SSC-2142691", "R-MMU-9026286", "R-RNO-9025106", "R-HSA-9023661", "R-MMU-2142688", "R-HSA-9018896", "R-SSC-9025106", "R-SSC-9018681", "R-RNO-9027604", "R-HSA-9018677", "R-HSA-9026290", "R-BTA-2142712", "R-RNO-9018676", "R-MMU-9018676", "R-SSC-2142770", "R-BTA-9018896", "R-MMU-9025106", "R-BTA-2142691", "R-HSA-9026403", "R-RNO-2142770", "R-HSA-6785807", "R-RNO-9026286", "R-BTA-2142770", "R-MMU-2142770", "R-RNO-9018682", "R-SSC-9018677", "R-SSC-9023661", "R-BTA-9026286", "R-HSA-9012546", "R-RNO-9018677", "R-MMU-2142691", "R-HSA-9025106", "R-MMU-6798695", "R-HSA-2142770", "R-MMU-2142712", "R-RNO-6798695", "R-RNO-9018896", "R-BTA-9018681", "R-MMU-9018896", "R-MMU-2142696", "R-HSA-9018681", "R-BTA-9018677", "R-RNO-2142700", "R-MMU-9018681", "R-MMU-9023661", "R-HSA-2142712", "R-RNO-2142712", "R-HSA-2142696", "R-RNO-2142696", "R-HSA-9027604", "R-SSC-9018896", "R-SSC-9026286", "R-MMU-2142700", "R-MMU-9018682", "R-BTA-9023661", "R-MMU-9018677", "R-BTA-9025106", "R-RNO-9026290", "R-HSA-9020265", "R-RNO-9026403", "R-MMU-9026290", "R-HSA-2142688", "R-RNO-2142691", "R-MMU-9026403", "R-MMU-9020265", "R-RNO-9018681", "R-SSC-2142712", "R-HSA-9018682", "R-HSA-9026286", "R-RNO-9020265"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-RNO-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-SSC-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-RNO-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-HSA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SSC-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-SSC-9018681:r:Biosynthesis of protectins", "R-RNO-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-HSA-9018677:r:Biosynthesis of DHA-derived SPMs", "R-HSA-9026290:r:Biosynthesis of DPAn-3-derived maresins", "R-BTA-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-SSC-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9026403:r:Biosynthesis of DPAn-3-derived 13-series resolvins", "R-RNO-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-BTA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-MMU-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-RNO-9018682:r:Biosynthesis of maresins", "R-SSC-9018677:r:Biosynthesis of DHA-derived SPMs", "R-SSC-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-BTA-9026286:r:Biosynthesis of DPAn-3-derived protectins and resolvins", "R-HSA-9012546:r:Interleukin-18 signaling", "R-RNO-9018677:r:Biosynthesis of DHA-derived SPMs", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9025106:r:Biosynthesis of DPAn-6 SPMs", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-MMU-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-BTA-9018681:r:Biosynthesis of protectins", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-MMU-2142696:r:Synthesis of Hepoxilins (HX) and Trioxilins (TrX)", "R-HSA-9018681:r:Biosynthesis of protectins", "R-BTA-9018677:r:Biosynthesis of DHA-derived SPMs", "R-RNO-2142700:r:Biosynthesis of Lipoxins (LX)", "R-MMU-9018681:r:Biosynthesis of protectins", "R-MMU-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-RNO-2142712:r:Synthesis of 12-eicosatetraenoic acid derivatives", "R-HSA-2142696:r:Synthesis of Hepoxilins (HX) and Trioxilins (TrX)", "R-RNO-2142696:r:Synthesis of 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"type": "Homologous_superfamily"}, "IPR036236": {"description": "Zinc finger C2H2 superfamily", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_sf", "pathway_ids": ["R-RNO-9031628", "R-RNO-6781823", "R-DME-9762293", "R-MMU-9933946", "R-HSA-6807505", "R-MMU-77588", "R-DME-216217", "R-HSA-8951664", "R-MMU-9770562", "R-HSA-8936459", "R-MMU-69895", "R-MMU-3214815", "R-HSA-73856", "R-RNO-72163", "R-BTA-76071", "R-HSA-9617828", "R-RNO-9018519", "R-BTA-3214841", "R-DME-5696394", "R-HSA-6804759", "R-SCE-6807505", "R-HSA-9818030", "R-HSA-9844594", "R-HSA-6804754", "R-MMU-5610787", "R-CEL-9770562", "R-DME-390193", "R-DME-9764725", "R-MMU-76061", "R-HSA-76061", "R-DME-214869", "R-DME-8941855", "R-DME-5610787", "R-MMU-5696394", "R-HSA-9616222", "R-HSA-749476", "R-DME-214842", "R-HSA-5610783", "R-HSA-9701898", "R-HSA-9614657", "R-HSA-210746", "R-HSA-9834899", "R-BTA-72163", "R-SCE-76061", "R-MMU-3214841", "R-MMU-9843940", "R-MMU-9934037", "R-SPO-9018519", "R-MMU-72163", "R-MMU-2173796", 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"R-DME-209360", "R-HSA-381038", "R-HSA-9839394", "R-HSA-9770562", "R-HSA-9768777", "R-BTA-72165", "R-MMU-3899300", "R-HSA-381340", "R-MMU-9013424", "R-HSA-9707616", "R-HSA-69895", "R-MMU-3214858", "R-DRE-3899300", "R-MMU-8943724", "R-DME-209446", "R-HSA-8939902", "R-RNO-3214847", "R-MMU-72165", "R-RNO-9762293", "R-RNO-9770562", "R-MMU-450341", "R-HSA-9761174", "R-HSA-9856649", "R-HSA-3214847", "R-DME-2173796", "R-BTA-6807505", "R-RNO-450341", "R-HSA-9725370", "R-HSA-2426168", "R-DRE-72165", "R-MMU-9707564", "R-HSA-6804116", "R-HSA-1989781", "R-MMU-5632684", "R-HSA-2151201", "R-RNO-6807505", "R-HSA-6804115", "R-HSA-9700645", "R-RNO-3214858", "R-HSA-9758919", "R-HSA-9013424", "R-HSA-6796648", "R-HSA-9764790", "R-DRE-3214815", "R-HSA-1368108", "R-DRE-6807505", "R-HSA-6781823", "R-HSA-8941855", "R-HSA-8943724", "R-MMU-3232118", "R-HSA-9926550", "R-CEL-4551638", "R-HSA-9933387", "R-HSA-9707564", "R-DME-214844", "R-CEL-9762293", "R-HSA-4551638", "R-HSA-9018519", "R-HSA-212436", 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"R-HSA-77588", "R-DME-5689603", "R-DME-3232118", "R-SPO-983168", "R-RNO-212436", "R-SPO-3214858", "R-DME-216167", "R-MMU-5689603", "R-HSA-111367", "R-DME-983231", "R-HSA-9918481", "R-HSA-2173796", "R-HSA-9931509", "R-BTA-212300", "R-HSA-9762293", "R-DME-209190", "R-HSA-9013508", "R-DME-212300", "R-RNO-6782135", "R-CEL-3214841", "R-HSA-9679191", "R-HSA-983168", "R-HSA-6782135", "R-MMU-9764725", "R-HSA-5632684", "R-HSA-9824585", "R-MMU-8876725", "R-HSA-9830674", "R-DME-5632684", "R-HSA-5687128", "R-DRE-3214841", "R-CEL-9764725", "R-DME-8936459", "R-HSA-6803204", "R-XTR-6782135", "R-RNO-8876725", "R-HSA-9843940", "R-HSA-9831926", "R-HSA-2892247", "R-HSA-3899300", "R-HSA-9933946", "R-HSA-9633012"], "pathways": ["R-RNO-9031628:r:NGF-stimulated transcription", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-9762293:r:Regulation of CDH11 gene transcription", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-6807505:r:RNA polymerase II 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"R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-6804754:r:Regulation of TP53 Expression", "R-MMU-5610787:r:Hedgehog 'off' state", "R-CEL-9770562:r:mRNA Polyadenylation", "R-DME-390193:r:Transcriptional activation by YKI", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-DME-8941855:r:RUNX3 regulates CDKN1A transcription", "R-DME-5610787:r:Hedgehog 'off' state", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-210746:r:Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells", "R-HSA-9834899:r:Specification of the neural plate border", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-9031628:r:NGF-stimulated transcription", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-9762293:r:Regulation of CDH11 gene transcription", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-111367:r:SLBP independent Processing of Histone Pre-mRNAs", "R-SPO-8951664:r:Neddylation", "R-HSA-9031628:r:NGF-stimulated transcription", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5660489:r:MTF1 activates gene expression", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-SSC-9031628:r:NGF-stimulated transcription", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-3214815:r:HDACs deacetylate histones", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CFA-9770562:r:mRNA Polyadenylation", "R-HSA-9832991:r:Formation of the posterior neural plate", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-912446:r:Meiotic recombination", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-DME-210671:r:Transcriptional repression by nuclear factors", "R-DME-216119:r:Activation of CI", "R-MMU-8941855:r:RUNX3 regulates CDKN1A transcription", "R-DRE-9031628:r:NGF-stimulated transcription", "R-BTA-212436:r:Generic Transcription Pathway", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9768777:r:Regulation of NPAS4 gene transcription", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9707616:r:Heme signaling", "R-HSA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DME-209446:r:N-HH ligand not bound to PTC receptor complex", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-3214847:r:HATs acetylate histones", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-9762293:r:Regulation of CDH11 gene transcription", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-9761174:r:Formation of intermediate mesoderm", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-DRE-3214815:r:HDACs deacetylate histones", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene 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"R-DME-390247", "R-BTA-71064", "R-DDI-9837999", "R-HSA-381038", "R-MMU-71064", "R-MMU-2046106", "R-MMU-193368", "R-DDI-2046106", "R-DME-9033241", "R-MMU-9033241", "R-RNO-9837999", "R-CEL-390247", "R-MMU-77285", "R-BTA-77348", "R-RNO-70895", "R-SCE-389887", "R-MMU-77305", "R-DME-193368", "R-BTA-390247", "R-HSA-9033500", "R-HSA-9033241", "R-HSA-9914355", "R-RNO-390247"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-71064:r:Lysine catabolism", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-71064:r:Lysine catabolism", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", 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"R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-CEL-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-BTA-71064:r:Lysine catabolism", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-71064:r:Lysine catabolism", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-CEL-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-9914355:r:Isovaleric acidemia", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Homologous_superfamily"}, "IPR036251": {"description": "Arginine repressor, C-terminal domain superfamily", "go_ids": ["GO:0034618", "GO:0051259"], "go_terms": ["GO:0034618:arginine binding:F", "GO:0051259:protein complex oligomerization:P"], "name": "Arg_repress_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036252": {"description": "Proteasome activator superfamily", "go_ids": ["GO:0008537"], "go_terms": ["GO:0008537:proteasome activator complex:C"], "name": "Proteasome_activ_sf", "pathway_ids": ["R-MMU-9907900", "R-BTA-9912633", "R-BTA-1236978", "R-RNO-9907900", "R-DDI-9907900", "R-DDI-9912633", "R-HSA-1236978", "R-HSA-8950505", "R-RNO-1236974", "R-RNO-9912633", "R-DDI-1236974", "R-DDI-1236978", "R-HSA-9907900", "R-SSC-9907900", "R-MMU-1236974", "R-HSA-9912633", "R-HSA-1236974", "R-MMU-1236978", "R-BTA-1236974", "R-MMU-9912633", "R-RNO-1236978", "R-BTA-9907900"], "pathways": ["R-MMU-9907900:r:Proteasome assembly", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-9907900:r:Proteasome assembly", "R-DDI-9907900:r:Proteasome assembly", "R-DDI-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-1236974:r:ER-Phagosome pathway", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-1236974:r:ER-Phagosome pathway", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9907900:r:Proteasome assembly", "R-SSC-9907900:r:Proteasome assembly", "R-MMU-1236974:r:ER-Phagosome pathway", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-1236974:r:ER-Phagosome pathway", "R-MMU-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-9907900:r:Proteasome assembly"], "type": "Homologous_superfamily"}, "IPR036253": {"description": "Flavivirus glycoprotein, central and dimerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "Glycoprot_cen/dimer_sf", "pathway_ids": ["R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Homologous_superfamily"}, "IPR036254": {"description": "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily", "go_ids": ["GO:0004663", "GO:0008270"], "go_terms": ["GO:0004663:Rab geranylgeranyltransferase activity:F", "GO:0008270:zinc ion binding:F"], "name": "RabGGT_asu_insert-dom_sf", "pathway_ids": ["R-BTA-6803205", "R-BTA-8873719", "R-RNO-6803205", "R-HSA-6803205", "R-MMU-6803205", "R-RNO-8873719", "R-HSA-8873719", "R-MMU-8873719"], "pathways": ["R-BTA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-BTA-8873719:r:RAB geranylgeranylation", "R-RNO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-MMU-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-RNO-8873719:r:RAB geranylgeranylation", "R-HSA-8873719:r:RAB geranylgeranylation", "R-MMU-8873719:r:RAB geranylgeranylation"], "type": "Homologous_superfamily"}, "IPR036255": {"description": "YgfB-like superfamily", "go_ids": [], "go_terms": [], "name": "YgfB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036256": {"description": "Mu1/VP4 superfamily", "go_ids": ["GO:0046718", "GO:0046812", "GO:0039624"], "go_terms": ["GO:0046718:symbiont entry into host cell:P", "GO:0046812:host cell surface binding:F", "GO:0039624:viral outer capsid:C"], "name": "Mu1/VP4_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036257": {"description": "Cytochrome C oxidase subunit II, transmembrane domain superfamily", "go_ids": [], "go_terms": [], "name": "Cyt_c_oxidase_su2_TM_sf", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279", "R-GGA-9707564", "R-HSA-5419276", "R-DME-5628897", "R-DRE-611105", "R-GGA-9864848", "R-DRE-9864848", "R-BTA-9864848", "R-HSA-5628897", "R-GGA-5419276", "R-DME-9864848", "R-RNO-5419276", "R-HSA-9707564", "R-GGA-611105", "R-MMU-5628897", "R-MMU-611105", "R-HSA-9837999", "R-MMU-9864848", "R-DRE-5419276", "R-DDI-9837999", "R-DME-9707564", "R-RNO-5628897", "R-RNO-9707564", "R-DME-611105", "R-BTA-5628897", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-GGA-5628897", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-DRE-9707564", "R-DRE-5628897", "R-RNO-9864848", "R-MMU-9707564", "R-BTA-611105", "R-BTA-9707564"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-611105:r:Respiratory electron transport", "R-GGA-9864848:r:Complex IV assembly", "R-DRE-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-GGA-5419276:r:Mitochondrial translation termination", "R-DME-9864848:r:Complex IV assembly", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-GGA-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9864848:r:Complex IV assembly", "R-DRE-5419276:r:Mitochondrial translation termination", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-DME-611105:r:Respiratory electron transport", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR036258": {"description": "Apyrase superfamily", "go_ids": ["GO:0017110", "GO:0005509"], "go_terms": ["GO:0017110:nucleoside diphosphate phosphatase activity:F", "GO:0005509:calcium ion binding:F"], "name": "Apyrase_sf", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036259": {"description": "MFS transporter superfamily", "go_ids": [], "go_terms": [], "name": "MFS_trans_sf", "pathway_ids": ["R-MMU-8856828", "R-SCE-9707616", "R-CEL-181430", "R-SCE-9755088", "R-MMU-433692", "R-HSA-442660", "R-MMU-181430", "R-HSA-5619035", "R-HSA-425397", "R-HSA-5653890", "R-SSC-422356", "R-HSA-9662360", "R-MMU-9707616", "R-SPO-917937", "R-CEL-196807", "R-DME-196836", "R-DRE-1660661", "R-SPO-212676", "R-HSA-561048", "R-HSA-210991", "R-SSC-196836", "R-HSA-5619060", "R-PFA-422356", "R-CEL-5653890", "R-HSA-5250955", "R-MMU-200425", "R-CEL-427652", "R-HSA-196807", "R-CEL-4085001", "R-SCE-429593", "R-MMU-425397", "R-RNO-561048", "R-MMU-879518", "R-SPO-181429", "R-HSA-9748787", "R-BTA-442660", "R-DME-112311", "R-HSA-549127", "R-DDI-196757", "R-SSC-6798695", "R-HSA-879518", "R-RNO-9860276", "R-SSC-9749641", "R-SPO-425397", "R-CEL-210500", "R-DME-879518", "R-PFA-189200", "R-BTA-352230", "R-HSA-189483", "R-SSC-442660", "R-MMU-2672351", "R-MMU-4085001", "R-DRE-917937", "R-DME-442660", "R-RNO-8856828", "R-DME-8981373", "R-CEL-189451", "R-SCE-189200", "R-CEL-8856828", "R-HSA-427652", "R-HSA-5655799", "R-BTA-112311", "R-DME-6798695", "R-RNO-210500", "R-HSA-381340", "R-MMU-210500", "R-HSA-9707616", "R-CEL-8981373", "R-RNO-2161517", "R-CEL-9749641", "R-CEL-2672351", "R-RNO-422356", "R-HSA-8856825", "R-SCE-5653890", "R-MMU-549127", "R-MMU-1660661", "R-HSA-6798695", "R-RNO-427652", "R-BTA-9909505", "R-DME-9707616", "R-HSA-8856828", "R-CEL-6798695", "R-MMU-425410", "R-BTA-6798695", "R-RNO-5653890", "R-CEL-442660", "R-HSA-427975", "R-CFA-917937", "R-PFA-9755088", "R-CEL-200425", "R-RNO-212676", "R-BTA-196836", "R-HSA-5619068", "R-RNO-425410", "R-MMU-196757", "R-XTR-189200", "R-GGA-373920", "R-SCE-83936", "R-HSA-4085001", "R-RNO-189483", "R-SPO-189200", "R-RNO-9748787", "R-DRE-352230", "R-SSC-181430", "R-SCE-879518", "R-PFA-8981373", "R-SPO-427975", "R-MMU-427652", "R-HSA-264642", "R-HSA-2161517", "R-SSC-189200", "R-HSA-196757", "R-HSA-9860276", "R-HSA-5619110", "R-HSA-8935964", "R-DME-196807", "R-RNO-4085001", "R-MMU-6798695", "R-HSA-429593", "R-HSA-189451", "R-SCE-352230", "R-HSA-5619061", "R-DME-196757", "R-BTA-210500", "R-DME-427652", "R-DME-549127", "R-BTA-549127", "R-SSC-8981373", "R-CEL-2161517", "R-CEL-422356", "R-DME-264642", "R-XTR-210500", "R-MMU-83936", "R-RNO-189200", "R-HSA-9636383", "R-MMU-5653890", "R-RNO-159418", "R-RNO-9754706", "R-DRE-879518", "R-MMU-442660", "R-RNO-200425", "R-BTA-427975", "R-RNO-428643", "R-MMU-8981373", "R-CEL-112311", "R-CEL-196757", "R-HSA-5619095", "R-DRE-425410", "R-MMU-196836", "R-RNO-8856825", "R-HSA-83936", "R-RNO-9755088", "R-BTA-9860276", "R-HSA-5619043", "R-HSA-2160916", "R-DRE-196757", "R-MMU-112311", "R-MMU-196819", "R-HSA-1483191", "R-DRE-9707616", "R-HSA-9638334", "R-HSA-9845576", "R-HSA-917937", "R-DME-189200", "R-RNO-425397", "R-PFA-6798695", "R-GGA-352832", "R-RNO-196757", "R-HSA-9913143", "R-RNO-83936", "R-SPO-181430", "R-DME-422356", "R-MMU-210991", "R-MMU-1483191", "R-MMU-9755088", "R-CEL-561048", "R-DRE-189200", "R-DME-427975", "R-HSA-196836", "R-SCE-422356", "R-BTA-8981373", "R-HSA-210500", "R-BTA-181430", "R-CEL-917937", "R-HSA-181430", "R-HSA-3229133", "R-SCE-9845576", "R-HSA-9638482", "R-HSA-5619058", "R-DRE-1483191", "R-BTA-9707616", "R-HSA-189200", "R-HSA-196819", "R-RNO-196807", "R-MMU-9860276", "R-HSA-5619053", "R-PFA-83936", "R-HSA-433692", "R-CEL-549127", "R-HSA-1445148", "R-XTR-1660661", "R-BTA-917937", "R-HSA-9749641", "R-HSA-5619049", "R-SSC-549127", "R-HSA-5250992", "R-CEL-8856825", "R-HSA-212676", "R-SPO-9845576", "R-PFA-9748787", "R-RNO-6798695", "R-MMU-427975", "R-SCE-917937", "R-SCE-427975", "R-DME-200425", "R-RNO-196836", "R-HSA-2672351", "R-SCE-6798695", "R-GGA-1483191", "R-BTA-879518", "R-DME-1660661", "R-XTR-549127", "R-MMU-352230", "R-CEL-427975", "R-DME-5653890", "R-RNO-8981373", "R-MMU-917937", "R-HSA-352230", "R-HSA-181429", "R-RNO-442660", "R-RNO-352230", "R-PFA-196836", "R-HSA-5619066", "R-RNO-9707616", "R-DME-917937", "R-SSC-561048", "R-MMU-428643", "R-SSC-2161517", "R-PFA-5653890", "R-MMU-212676", "R-MMU-189451", "R-RNO-181430", "R-MMU-2161517", "R-HSA-210745", "R-GGA-210991", "R-CEL-2160916", "R-MMU-561048", "R-HSA-5619047", "R-HSA-200425", "R-HSA-5662702", "R-SPO-429593", "R-BTA-196757", "R-HSA-159418", "R-SCE-196757", "R-GGA-433692", "R-HSA-112311", "R-CFA-425410", "R-HSA-5619098", "R-HSA-422356", "R-DME-2161517", "R-SCE-8981373", "R-MMU-70263", "R-MMU-429593", "R-HSA-351906", "R-SCE-196836", "R-DME-9749641", "R-DDI-196819", "R-MMU-189483", "R-RNO-9793528", "R-HSA-70263", "R-SPO-8856825", "R-HSA-5619071", "R-HSA-425410", "R-MMU-9749641", "R-SPO-442380", "R-CEL-264642", "R-SSC-112311", "R-MMU-9748787", "R-CEL-9793528", "R-HSA-5619076", "R-RNO-917937", "R-DME-561048", "R-MMU-2160916", "R-BTA-189200", "R-XTR-1483191", "R-RNO-427975", "R-MMU-264642", "R-BTA-2161517", "R-HSA-9754706", "R-MMU-9754706", "R-CEL-429593", "R-DME-181430", "R-RNO-264642", "R-CEL-196819", "R-CEL-189200", "R-BTA-5653890", "R-RNO-181429", "R-RNO-433692", "R-MMU-196807", "R-MMU-8856825", "R-MMU-422356", "R-MMU-5662702", "R-CEL-196836", "R-MMU-9845576", "R-SCE-425397", "R-HSA-428643", "R-HSA-5250981", "R-MMU-189200", "R-DRE-442660", "R-DME-8856828", "R-HSA-5619070", "R-HSA-9755088", "R-RNO-112311", "R-DRE-8856825", "R-DME-8856825", "R-DRE-561048", "R-DRE-70263", "R-CEL-428643", "R-SCE-9748787", "R-RNO-210991", "R-BTA-9793528", "R-HSA-5250968", "R-MMU-181429", "R-HSA-1660661", "R-HSA-8981373", "R-RNO-879518", "R-RNO-429593", "R-MMU-9793528", "R-DRE-83936", "R-SSC-5653890", "R-SPO-9707616", "R-DRE-264642", "R-XTR-442660", "R-BTA-422356", "R-DME-2672351", "R-HSA-9793528", "R-HSA-9022699", "R-RNO-9749641", "R-DME-9793528", "R-SPO-196757", "R-RNO-2160916", "R-MMU-159418", "R-RNO-549127"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SCE-9707616:r:Heme signaling", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SCE-9755088:r:Ribavirin ADME", "R-MMU-433692:r:Proton-coupled monocarboxylate transport", "R-HSA-442660:r:SLC-mediated transport of neurotransmitters", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-5619035:r:Defective SLC17A5 causes Salla disease (SD) and ISSD", "R-HSA-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-HSA-5653890:r:Lactose synthesis", "R-SSC-422356:r:Regulation of insulin secretion", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-9707616:r:Heme signaling", "R-SPO-917937:r:Iron uptake and transport", "R-CEL-196807:r:Nicotinate metabolism", "R-DME-196836:r:Vitamin C (ascorbate) metabolism", "R-DRE-1660661:r:Sphingolipid de novo biosynthesis", "R-SPO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-561048:r:Organic anion transport by SLC22 transporters", "R-HSA-210991:r:Basigin interactions", "R-SSC-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-5619060:r:Defective CP causes aceruloplasminemia (ACERULOP)", "R-PFA-422356:r:Regulation of insulin secretion", "R-CEL-5653890:r:Lactose synthesis", "R-HSA-5250955:r:Toxicity of botulinum toxin type D (botD)", "R-MMU-200425:r:Carnitine shuttle", "R-CEL-427652:r:Sodium-coupled phosphate cotransporters", "R-HSA-196807:r:Nicotinate metabolism", "R-CEL-4085001:r:Sialic acid metabolism", "R-SCE-429593:r:Inositol transporters", "R-MMU-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-RNO-561048:r:Organic anion transport by SLC22 transporters", "R-MMU-879518:r:Organic anion transport by SLCO transporters", "R-SPO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-9748787:r:Azathioprine ADME", "R-BTA-442660:r:SLC-mediated transport of neurotransmitters", "R-DME-112311:r:Neurotransmitter clearance", "R-HSA-549127:r:SLC-mediated transport of organic cations", "R-DDI-196757:r:Metabolism of folate and pterines", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-879518:r:Organic anion transport by SLCO transporters", "R-RNO-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-SSC-9749641:r:Aspirin ADME", "R-SPO-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-879518:r:Organic anion transport by SLCO transporters", "R-PFA-189200:r:Cellular hexose transport", "R-BTA-352230:r:Amino acid transport across the plasma membrane", "R-HSA-189483:r:Heme degradation", "R-SSC-442660:r:SLC-mediated transport of neurotransmitters", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-4085001:r:Sialic acid metabolism", "R-DRE-917937:r:Iron uptake and transport", "R-DME-442660:r:SLC-mediated transport of neurotransmitters", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8981373:r:Intestinal hexose absorption", "R-CEL-189451:r:Heme biosynthesis", "R-SCE-189200:r:Cellular hexose transport", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-427652:r:Sodium-coupled phosphate cotransporters", "R-HSA-5655799:r:Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)", "R-BTA-112311:r:Neurotransmitter clearance", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9707616:r:Heme signaling", "R-CEL-8981373:r:Intestinal hexose absorption", "R-RNO-2161517:r:Abacavir transmembrane transport", "R-CEL-9749641:r:Aspirin ADME", "R-CEL-2672351:r:Stimuli-sensing channels", "R-RNO-422356:r:Regulation of insulin secretion", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-5653890:r:Lactose synthesis", "R-MMU-549127:r:SLC-mediated transport of organic cations", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-427652:r:Sodium-coupled phosphate cotransporters", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-9707616:r:Heme signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-425410:r:Metal ion SLC transporters", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-5653890:r:Lactose synthesis", "R-CEL-442660:r:SLC-mediated transport of neurotransmitters", "R-HSA-427975:r:Proton/oligopeptide cotransporters", "R-CFA-917937:r:Iron uptake and transport", "R-PFA-9755088:r:Ribavirin ADME", "R-CEL-200425:r:Carnitine shuttle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-BTA-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-5619068:r:Defective SLC2A10 causes arterial tortuosity syndrome (ATS)", "R-RNO-425410:r:Metal ion SLC transporters", "R-MMU-196757:r:Metabolism of folate and pterines", "R-XTR-189200:r:Cellular hexose transport", "R-GGA-373920:r:Pyruvate metabolism", "R-SCE-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-4085001:r:Sialic acid metabolism", "R-RNO-189483:r:Heme degradation", "R-SPO-189200:r:Cellular hexose transport", "R-RNO-9748787:r:Azathioprine ADME", "R-DRE-352230:r:Amino acid transport across the plasma membrane", "R-SSC-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SCE-879518:r:Organic anion transport by SLCO transporters", "R-PFA-8981373:r:Intestinal hexose absorption", "R-SPO-427975:r:Proton/oligopeptide cotransporters", "R-MMU-427652:r:Sodium-coupled phosphate cotransporters", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-2161517:r:Abacavir transmembrane transport", "R-SSC-189200:r:Cellular hexose transport", "R-HSA-196757:r:Metabolism of folate and pterines", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-5619110:r:Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-DME-196807:r:Nicotinate metabolism", "R-RNO-4085001:r:Sialic acid metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-429593:r:Inositol transporters", "R-HSA-189451:r:Heme biosynthesis", "R-SCE-352230:r:Amino acid transport across the plasma membrane", "R-HSA-5619061:r:Defective SLC33A1 causes spastic paraplegia 42 (SPG42)", "R-DME-196757:r:Metabolism of folate and pterines", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-427652:r:Sodium-coupled phosphate cotransporters", "R-DME-549127:r:SLC-mediated transport of organic cations", "R-BTA-549127:r:SLC-mediated transport of organic cations", 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"Homologous_superfamily"}, "IPR036270": {"description": "UPF0358 superfamily", "go_ids": [], "go_terms": [], "name": "UPF0358_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036271": {"description": "Tetracyclin repressor-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Tet_transcr_reg_TetR-rel_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036272": {"description": "Methuselah, N-terminal domain superfamily", "go_ids": ["GO:0004930"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F"], "name": "Methuselah_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036273": {"description": "CRAL/TRIO, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CRAL/TRIO_N_dom_sf", "pathway_ids": ["R-MMU-8877627", "R-HSA-9013405", "R-HSA-6798695", "R-DME-8877627", "R-RNO-432720", "R-DDI-2187335", "R-HSA-8877627", "R-HSA-432720", "R-DDI-432720", "R-BTA-2187335", "R-MMU-2453902", "R-RNO-8877627", "R-GGA-2187335", "R-GGA-2453902", "R-HSA-9008059", "R-HSA-9918438", "R-MMU-6798695", "R-MMU-2187335", "R-BTA-2453902", "R-DDI-8877627", "R-HSA-2187335", "R-MMU-432720", "R-DDI-2453902", "R-HSA-2453902"], "pathways": ["R-MMU-8877627:r:Vitamin E transport", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-8877627:r:Vitamin E transport", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-2187335:r:The retinoid cycle in cones (daylight vision)", "R-HSA-8877627:r:Vitamin E transport", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-8877627:r:Vitamin E transport", "R-GGA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-GGA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-9918438:r:Defective visual phototransduction due to RDH5 loss of function", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-2187335:r:The retinoid cycle in cones (daylight vision)", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DDI-8877627:r:Vitamin E transport", "R-HSA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Homologous_superfamily"}, "IPR036274": {"description": "HR1 repeat superfamily", "go_ids": [], "go_terms": [], "name": "HR1_rpt_sf", "pathway_ids": ["R-RNO-9013026", "R-SCE-399997", "R-SPO-2029485", "R-BTA-5625886", "R-MMU-9013106", "R-SCE-2029485", "R-SPO-389357", "R-RNO-9013149", "R-MMU-5625740", "R-SPO-202424", "R-SPO-76005", "R-SPO-9013106", "R-SCE-5607764", "R-RNO-5625740", "R-SCE-8980692", "R-SPO-5668599", "R-DRE-5666185", "R-HSA-203641", "R-SCE-9856530", "R-SPO-9634635", "R-BTA-5625740", "R-DME-9013149", "R-DRE-9013106", "R-SPO-5607764", "R-DME-8980692", "R-DME-5625886", "R-SPO-5218920", "R-SCE-1489509", "R-SPO-8980692", "R-HSA-9013149", "R-HSA-8980692", "R-DRE-9013026", "R-BTA-8980692", "R-DRE-8980692", "R-HSA-9013026", "R-SPO-2179392", "R-BTA-9013106", "R-SPO-6798695", "R-SPO-1489509", "R-SCE-2179392", "R-MMU-9856530", "R-MMU-8980692", "R-RNO-8980692", "R-SCE-6798695", "R-HSA-5625740", "R-HSA-9013106", "R-SPO-5218921", "R-DME-5625740", "R-SCE-76005", "R-HSA-5625886", "R-SPO-5625740", "R-SCE-1169091", "R-SPO-114516", "R-SCE-9634635", "R-RNO-5625886", "R-DRE-9013149", "R-MMU-5625886", "R-RNO-9013106", "R-DRE-9856530", "R-SCE-4419969", "R-SPO-1257604", "R-SPO-6804757", "R-SPO-399997", "R-SPO-9856530", "R-SCE-5625740", "R-MMU-5666185", "R-BTA-5666185", "R-SPO-114508", "R-SCE-114516", "R-HSA-5666185", "R-SPO-4419969", "R-DRE-5625740", "R-SPO-1169091", "R-SCE-9013106", "R-RNO-9856530", "R-SPO-2871837", "R-SCE-5218921", "R-SCE-114508", "R-MMU-9013026", "R-HSA-9856530", "R-SCE-5668599", "R-MMU-9013149", "R-SCE-202424", "R-DME-9856530", "R-SCE-2871837"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-SCE-399997:r:Acetylcholine regulates insulin secretion", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-9013106:r:RHOC GTPase cycle", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-SPO-202424:r:Downstream TCR signaling", "R-SPO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SPO-9013106:r:RHOC GTPase cycle", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-9013106:r:RHOC GTPase cycle", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-1489509:r:DAG and IP3 signaling", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-SPO-2179392:r:EGFR Transactivation by Gastrin", "R-BTA-9013106:r:RHOC GTPase cycle", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-1489509:r:DAG and IP3 signaling", "R-SCE-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-SCE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SPO-5625740:r:RHO GTPases activate PKNs", "R-SCE-1169091:r:Activation of NF-kappaB in B cells", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-SCE-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-RNO-9013106:r:RHOC GTPase cycle", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-399997:r:Acetylcholine regulates insulin secretion", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-SPO-114508:r:Effects of PIP2 hydrolysis", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-DRE-5625740:r:RHO GTPases activate PKNs", "R-SPO-1169091:r:Activation of NF-kappaB in B cells", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-2871837:r:FCERI mediated NF-kB activation", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-SCE-114508:r:Effects of PIP2 hydrolysis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-SCE-202424:r:Downstream TCR signaling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-2871837:r:FCERI mediated NF-kB activation"], "type": "Homologous_superfamily"}, "IPR036275": {"description": "YdgH-like superfamily", "go_ids": [], "go_terms": [], "name": "YdgH-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036276": {"description": "Ribonuclease H, C-terminal", "go_ids": [], "go_terms": [], "name": "RNaseH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR036277": {"description": "SMCs flexible hinge superfamily", "go_ids": ["GO:0051276", "GO:0005515", "GO:0005524", "GO:0005694"], "go_terms": ["GO:0051276:chromosome organization:P", "GO:0005515:protein binding:F", "GO:0005524:ATP binding:F", "GO:0005694:chromosome:C"], "name": "SMC_hinge_sf", "pathway_ids": ["R-SCE-3108214", "R-HSA-2468052", "R-SPO-2470946", "R-BTA-2468052", "R-HSA-2467813", "R-HSA-3108214", "R-RNO-2500257", "R-MMU-2467813", "R-RNO-2470946", "R-HSA-2514853", "R-BTA-3108214", "R-RNO-3108214", "R-HSA-1221632", "R-CEL-2299718", "R-BTA-2467813", "R-DDI-2468052", "R-CEL-3108214", "R-BTA-2500257", "R-RNO-2468052", "R-HSA-2299718", "R-SCE-2514853", "R-HSA-9018519", "R-DDI-2470946", "R-CEL-2500257", "R-BTA-2470946", "R-SPO-2500257", "R-SCE-2468052", "R-MMU-2500257", "R-SPO-3108214", "R-HSA-2500257", "R-SPO-2514853", "R-CEL-2470946", "R-HSA-2470946", "R-DDI-2514853", "R-MMU-2514853", "R-DDI-2500257", "R-SCE-2500257", "R-DDI-2299718", "R-MMU-2299718", "R-RNO-2467813", "R-MMU-3108214", "R-CEL-2468052", "R-DDI-3108214", "R-MMU-2468052", "R-MMU-2470946"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-BTA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-RNO-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1221632:r:Meiotic synapsis", "R-CEL-2299718:r:Condensation of Prophase Chromosomes", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-DDI-2468052:r:Establishment of Sister Chromatid Cohesion", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-SCE-2514853:r:Condensation of Prometaphase Chromosomes", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DDI-2470946:r:Cohesin Loading onto Chromatin", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-2470946:r:Cohesin Loading onto Chromatin", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-2514853:r:Condensation of Prometaphase Chromosomes", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-DDI-2514853:r:Condensation of Prometaphase Chromosomes", "R-MMU-2514853:r:Condensation of Prometaphase Chromosomes", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DDI-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin"], "type": "Homologous_superfamily"}, "IPR036278": {"description": "Sialidase superfamily", "go_ids": [], "go_terms": [], "name": "Sialidase_sf", "pathway_ids": ["R-HSA-168255", "R-MMU-9840310", "R-RNO-9840310", "R-HSA-6798695", "R-SSC-6798695", "R-HSA-168288", "R-HSA-9840310", "R-RNO-8866376", "R-BTA-6798695", "R-BTA-4085001", "R-HSA-168874", "R-HSA-168336", "R-HSA-168303", "R-HSA-192823", "R-SSC-9840310", "R-HSA-168302", "R-BTA-9840310", "R-SSC-4085001", "R-MMU-8866376", "R-MMU-4085001", "R-HSA-168275", "R-RNO-4085001", "R-HSA-168316", "R-MMU-6798695", "R-HSA-168298", "R-HSA-198933", "R-HSA-168277", "R-HSA-8866376", "R-HSA-4341670", "R-HSA-4085001", "R-RNO-6798695"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-RNO-8866376:r:Reelin signalling pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-4085001:r:Sialic acid metabolism", "R-HSA-168874:r:Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-9840310:r:Glycosphingolipid catabolism", "R-HSA-168302:r:Budding", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-SSC-4085001:r:Sialic acid metabolism", "R-MMU-8866376:r:Reelin signalling pathway", "R-MMU-4085001:r:Sialic acid metabolism", "R-HSA-168275:r:Entry of Influenza Virion 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"R-RNO-997272", "R-HSA-2514859", "R-HSA-456926", "R-RNO-8964616", "R-DME-1296041", "R-BTA-416476", "R-MMU-418217", "R-HSA-381676", "R-BTA-418555", "R-BTA-418592", "R-MMU-997272", "R-HSA-428930", "R-CEL-997272", "R-CEL-1296041", "R-RNO-2514859", "R-CFA-500657", "R-MMU-9856530", "R-CFA-9634597", "R-CEL-400042", "R-CEL-392451", "R-CFA-400042", "R-HSA-416476", "R-CEL-416476", "R-CEL-6814122", "R-CFA-6814122", "R-CFA-420092", "R-MMU-2514859", "R-CEL-202040", "R-BTA-997272", "R-HSA-997272", "R-HSA-381771", "R-HSA-163359", "R-HSA-9660821", "R-BTA-392451", "R-DME-418597", "R-MMU-6814122", "R-MMU-500657", "R-HSA-8964616", "R-CFA-9009391", "R-CFA-428930", "R-RNO-381676", "R-CEL-418594", "R-RNO-428930", "R-RNO-1296041", "R-MMU-418592", "R-RNO-4086398", "R-HSA-418594", "R-CFA-8964315", "R-BTA-428930", "R-MMU-416482", "R-CFA-1296041", "R-BTA-418217", "R-CEL-2514859", "R-CFA-416482", "R-HSA-392451"], "pathways": ["R-BTA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-CFA-418597:r:G alpha 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"R-CFA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-CEL-4086398:r:Ca2+ pathway", "R-HSA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-416476:r:G alpha (q) signalling events", "R-CFA-4086398:r:Ca2+ pathway", "R-HSA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CFA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-BTA-418597:r:G alpha (z) signalling events", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-MMU-420092:r:Glucagon-type ligand receptors", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-456926:r:Thrombin signalling through proteinase 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signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-MMU-418555:r:G alpha (s) signalling events", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-RNO-392170:r:ADP signalling through P2Y purinoceptor 12", "R-RNO-418597:r:G alpha (z) signalling events", "R-DME-428930:r:Thromboxane signalling through TP receptor", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-BTA-420092:r:Glucagon-type ligand receptors", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-202040:r:G-protein activation", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-202040:r:G-protein activation", "R-BTA-418594:r:G alpha (i) signalling events", "R-BTA-1296041:r:Activation of G protein gated Potassium channels", "R-CFA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-420092:r:Glucagon-type ligand receptors", "R-HSA-202040:r:G-protein activation", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-428930:r:Thromboxane signalling through TP receptor", "R-CEL-428930:r:Thromboxane signalling through TP receptor", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-420092:r:Glucagon-type ligand receptors", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-DME-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CFA-202040:r:G-protein activation", "R-MMU-381753:r:Olfactory Signaling Pathway", "R-BTA-2485179:r:Activation of the phototransduction cascade", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-DME-1296041:r:Activation of G protein gated Potassium channels", "R-BTA-416476:r:G alpha (q) signalling events", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-418555:r:G alpha (s) signalling events", "R-BTA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-428930:r:Thromboxane signalling through TP receptor", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CFA-500657:r:Presynaptic function of Kainate receptors", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CFA-9634597:r:GPER1 signaling", "R-CEL-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-CFA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-416476:r:G alpha (q) signalling events", "R-CEL-416476:r:G alpha (q) signalling events", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-CFA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-CFA-420092:r:Glucagon-type ligand receptors", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-202040:r:G-protein activation", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-BTA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DME-418597:r:G alpha (z) signalling events", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-428930:r:Thromboxane signalling through TP receptor", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-418594:r:G alpha (i) signalling events", "R-RNO-428930:r:Thromboxane signalling through TP receptor", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-4086398:r:Ca2+ pathway", "R-HSA-418594:r:G alpha (i) signalling events", "R-CFA-8964315:r:G beta:gamma signalling through BTK", "R-BTA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CFA-1296041:r:Activation of G protein gated Potassium channels", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma"], "type": "Homologous_superfamily"}, "IPR036285": {"description": "PRP4-like superfamily", "go_ids": [], "go_terms": [], "name": "PRP4-like_sf", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Homologous_superfamily"}, "IPR036286": {"description": "LexA/Signal peptidase-like superfamily", "go_ids": [], "go_terms": [], "name": "LexA/Signal_pep-like_sf", "pathway_ids": ["R-HSA-1799339", "R-HSA-9918432", "R-HSA-9760173", "R-CFA-422085", "R-HSA-422085", "R-RNO-9768727", "R-MMU-422085", "R-BTA-422085", "R-CFA-9768727", "R-HSA-9828806", "R-BTA-9768727", "R-RNO-422085", "R-HSA-381771", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-400511"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9760173:r:Secretion of toxins", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Homologous_superfamily"}, "IPR036287": {"description": "Rv1873-like superfamily", "go_ids": [], "go_terms": [], "name": "Rv1873-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036288": {"description": "Aconitase B, HEAT-like domain superfamily", "go_ids": ["GO:0006099", "GO:0003994"], "go_terms": ["GO:0006099:tricarboxylic acid cycle:P", "GO:0003994:aconitate hydratase activity:F"], "name": "Aconitase_B_HEAT-like_dom_sf", "pathway_ids": ["PWY-5747"], "pathways": ["PWY-5747:t:2-methylcitrate cycle II"], "type": "Homologous_superfamily"}, "IPR036289": {"description": "Hypothetical protein YfhH", "go_ids": [], "go_terms": [], "name": "YfhH", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036290": {"description": "Phenylalanine zipper superfamily", "go_ids": [], "go_terms": [], "name": "Phe_ZIP_sf", "pathway_ids": ["R-RNO-1170546", "R-MMU-1433559", "R-HSA-1433559", "R-MMU-1170546", "R-HSA-1170546", "R-RNO-983231", "R-HSA-983231", "R-MMU-982772", "R-MMU-9706369", "R-RNO-982772", "R-RNO-1433559", "R-MMU-983231", "R-HSA-2586552", "R-HSA-982772", "R-HSA-9706369"], "pathways": ["R-RNO-1170546:r:Prolactin receptor signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-982772:r:Growth hormone receptor signaling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-982772:r:Growth hormone receptor signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-9706369:r:Negative regulation of FLT3"], "type": "Homologous_superfamily"}, "IPR036291": {"description": "NAD(P)-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "NAD(P)-bd_dom_sf", "pathway_ids": ["R-GGA-5365859", "R-HSA-9013405", "R-RNO-193807", "R-BTA-5689880", "R-DRE-390247", "R-HSA-6799198", "R-DME-8866907", "R-SCE-156581", "R-SCE-446199", "R-DRE-2453902", "R-HSA-1614635", "R-DDI-71064", "R-SCE-71384", "R-SSC-77346", "R-DRE-8964539", "R-CEL-2161541", "R-MMU-5689880", "R-SPO-1614635", "R-HSA-9662360", "R-CEL-8964539", "R-HSA-173599", "R-BTA-193993", "R-RNO-917977", "R-SPO-5365859", "R-DDI-6798695", "R-SPO-5652227", "R-HSA-193775", "R-SCE-70171", "R-BTA-70171", "R-DME-70171", "R-SSC-1482798", "R-MMU-1296052", "R-MMU-156581", "R-MMU-2151201", "R-SCE-71064", "R-HSA-8964539", "R-RNO-193775", "R-MMU-6803204", "R-RNO-9764725", "R-HSA-5662853", "R-SSC-5365859", "R-MMU-2187335", "R-HSA-2046106", "R-MMU-77288", "R-CEL-6787639", "R-MMU-71336", "R-RNO-193993", "R-HSA-193368", "R-RNO-75105", "R-HSA-2161541", "R-BTA-9764725", "R-HSA-6803205", "R-DME-1483166", "R-HSA-189483", "R-HSA-114608", "R-HSA-9013148", "R-BTA-1614635", "R-SPO-77346", "R-RNO-390247", "R-RNO-71403", "R-SSC-194002", "R-DDI-5628897", "R-MMU-2046106", "R-GGA-2161541", "R-MMU-3899300", "R-DDI-1474151", "R-MMU-2162123", "R-DDI-70171", "R-HSA-1482798", "R-RNO-71064", "R-MMU-1474151", "R-RNO-70895", "R-MMU-1251985", "R-SCE-9837999", "R-DME-71403", "R-HSA-9033500", "R-SCE-70635", "R-HSA-75876", "R-SCE-1483166", "R-HSA-975634", "R-MMU-1660661", "R-DRE-193048", "R-HSA-6798695", "R-RNO-70263", "R-HSA-2151201", "R-HSA-389599", "R-HSA-8866904", "R-HSA-5578997", "R-CEL-6798695", "R-BTA-6798695", "R-CEL-193048", "R-DDI-70263", "R-HSA-5339700", "R-MMU-77352", "R-MMU-1614635", "R-GGA-373920", "R-HSA-5609977", "R-MMU-193048", "R-RNO-189483", "R-DME-77346", "R-BTA-8964539", "R-HSA-425381", "R-SPO-70635", "R-BTA-194002", "R-RNO-2162123", "R-MMU-6799198", "R-DRE-8866904", "R-GGA-352875", "R-HSA-196757", "R-MMU-70635", "R-MMU-5365859", "R-MMU-917977", "R-BTA-2453902", "R-HSA-6785470", "R-DME-1300642", "R-SPO-6798695", "R-BTA-6807062", "R-RNO-2142700", "R-DDI-71336", "R-HSA-6787450", "R-DRE-75876", "R-DME-6787639", "R-XTR-75896", "R-CEL-3769402", "R-RNO-114608", "R-DRE-75105", "R-DDI-9856872", "R-CEL-8964572", "R-MMU-6807047", "R-HSA-9035034", "R-HSA-193993", "R-DME-3899300", "R-HSA-75896", "R-DME-390247", "R-BTA-71064", "R-DDI-70370", "R-DRE-156581", 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"R-MMU-9837999", "R-RNO-77346", "R-HSA-1474151", "R-HSA-77288", "R-RNO-9035034", "R-RNO-2161541", "R-DDI-2161541", "R-DME-5365859", "R-HSA-199220", "R-DME-2046106", "R-HSA-9918440", "R-HSA-1483166", "R-RNO-9757110", "R-RNO-8964539", "R-HSA-9640463", "R-CEL-70895", "R-MMU-389661", "R-HSA-9837999", "R-DDI-71403", "R-DME-75896", "R-RNO-9640463", "R-MMU-70268", "R-HSA-163765", "R-DDI-9837999", "R-HSA-70635", "R-CEL-70263", "R-DME-8964539", "R-MMU-77305", "R-XTR-9013406", "R-BTA-196757", "R-SCE-8964539", "R-RNO-3769402", "R-HSA-2426168", "R-MMU-9707564", "R-RNO-1482798", "R-HSA-1989781", "R-DDI-71384", "R-SSC-9033241", "R-DDI-75105", "R-SCE-77346", "R-HSA-9856872", "R-CEL-77348", "R-MMU-425381", "R-RNO-8964572", "R-MMU-189483", "R-RNO-70171", "R-HSA-70263", "R-BTA-2162123", "R-HSA-9707564", "R-RNO-156581", "R-MMU-5628897", "R-SPO-71336", "R-MMU-5652227", "R-BTA-425381", "R-BTA-5652227", "R-CEL-4641265", "R-CEL-114608", "R-CEL-77310", "R-SPO-70370", "R-HSA-977347", "R-SPO-71384", "R-DME-173599", "R-BTA-70268", "R-SCE-193144", "R-GGA-8866907", "R-DRE-75896", "R-PFA-5628897", "R-BTA-5661270", "R-SPO-8964539", "R-HSA-75105", "R-RNO-193368", "R-DME-5628897", "R-MMU-9018896", "R-SPO-193144", "R-RNO-4641265", "R-HSA-3769402", "R-DME-2161541", "R-BTA-1855183", "R-PFA-71336", "R-HSA-5628897", "R-BTA-8964208", "R-MMU-75896", "R-BTA-173599", "R-DME-1855183", "R-HSA-112043", "R-MMU-70895", "R-SPO-1483166", "R-BTA-189483", "R-MMU-1855183", "R-DDI-156581", "R-HSA-9918481", "R-HSA-70171", "R-DRE-5689880", "R-DRE-70263", "R-HSA-8866907", "R-MMU-977347", "R-SSC-77350", "R-MMU-8964539", "R-HSA-4641265", "R-RNO-9837999", "R-HSA-1660661", "R-CEL-70370", "R-SSC-193048", "R-CEL-70268", "R-DRE-70268", "R-HSA-6803204", "R-MMU-8964572", "R-MMU-9856872", "R-XTR-173599", "R-SPO-1660661", "R-SPO-196757", "R-RNO-9861718", "R-SPO-70171", "R-CEL-156581", "R-XTR-1971475", "R-RNO-6799198", "R-HSA-9918487", "R-MMU-75876", "R-MMU-199220", "R-HSA-77346", "R-HSA-203615", "R-CEL-71384", "R-MMU-389599", "R-MMU-975634", "R-HSA-6807047", "R-MMU-389887", "R-CEL-71403", "R-HSA-193048", "R-DRE-1660661", "R-HSA-77352", "R-CEL-71336", "R-XTR-2453902", "R-MMU-9018676", "R-MMU-9035034", "R-HSA-983695", "R-SPO-71064", "R-MMU-4641265", "R-DDI-389661", "R-DME-70263", "R-BTA-193048", "R-RNO-203615", "R-DRE-5365859", "R-HSA-5652227", "R-DRE-194002", "R-MMU-193807", "R-CFA-193048", "R-CEL-77350", "R-HSA-9667769", "R-DME-156581", "R-MMU-193775", "R-DDI-70895", "R-XTR-9856872", "R-HSA-1251985", "R-SCE-2187335", "R-HSA-77350", "R-HSA-77285", "R-RNO-199220", "R-DME-71336", "R-GGA-352882", "R-DME-2151201", "R-MMU-77310", "R-MMU-2142700", "R-MMU-193368", "R-SPO-5628897", "R-SPO-2161541", "R-DME-5578775", "R-CEL-77352", "R-HSA-2871809", "R-GGA-70171", "R-CFA-75105", "R-HSA-6787639", "R-MMU-193993", "R-CEL-75876", "R-CFA-193993", "R-SCE-71403", "R-HSA-193144", "R-DRE-1296052", "R-MMU-6787639", "R-RNO-1296052", "R-HSA-2142691", "R-BTA-4641265", "R-DRE-77111", "R-RNO-1483166", "R-RNO-2046106", "R-GGA-1251985", "R-RNO-173599", "R-RNO-70268", "R-DRE-6798695", "R-MMU-196757", "R-MMU-71403", "R-RNO-1474151", "R-HSA-1855183", "R-MMU-1482798", "R-DME-425381", "R-BTA-1296052", "R-BTA-9856872", "R-BTA-70895", "R-SCE-6807062", "R-DME-389887", "R-SCE-5661270", "R-CEL-5628897", "R-HSA-389887", "R-SCE-70370", "R-RNO-77108", "R-HSA-71384", "R-DDI-6799198", "R-HSA-193807", "R-CEL-9856872", "R-GGA-70263", "R-HSA-5218921", "R-BTA-6807047", "R-DDI-203615", "R-DDI-1614635", "R-BTA-70263", "R-MMU-9013406", "R-RNO-389599", "R-HSA-70370", "R-MMU-6798695", "R-MMU-211945", "R-MMU-114608", "R-DME-196757", "R-HSA-9757110", "R-RNO-75876", "R-DME-8866904", "R-XTR-1483166", "R-HSA-5661270", "R-HSA-77111", "R-MMU-5661270", "R-MMU-194002", "R-SPO-9856872", "R-HSA-2162123", "R-HSA-8964208", "R-RNO-9707564", "R-CEL-1483166", "R-HSA-70268", "R-BTA-1660661", "R-SSC-71403", "R-BTA-156581", "R-CEL-9764725", "R-RNO-2151201", "R-RNO-196757", "R-RNO-9856872", "R-MMU-193144", "R-HSA-3899300", "R-DRE-1251985", "R-DME-1614635", "R-SPO-70263", "R-MMU-71384", "R-HSA-9013409", "R-HSA-2142700", "R-DDI-8964539", "R-XTR-193048", "R-SCE-5628897", "R-DDI-1660661", "R-DRE-77346", "R-HSA-8868766", "R-HSA-5689880", "R-HSA-1489509", "R-DDI-70635", "R-HSA-499943", "R-SPO-5661270", "R-XTR-156581", "R-HSA-9818025", "R-SPO-71403", "R-DME-9018896", "R-DRE-8866907", "R-HSA-9018896", "R-CEL-193144", "R-SPO-6807062", "R-HSA-71403", "R-RNO-193144", "R-RNO-1855183", "R-SSC-77352", "R-RNO-77111", "R-RNO-5628897", "R-HSA-70895", "R-RNO-71384", "R-HSA-9764725", "R-RNO-71336", "R-HSA-389661", "R-DME-9861718", "R-SCE-9856872", "R-RNO-211945", "R-MMU-1483166", "R-DRE-173599", "R-DRE-446199", "R-CEL-2187335", "R-HSA-1296052", "R-HSA-917977", "R-RNO-70370", "R-MMU-446199", "R-RNO-6807047", "R-HSA-9664323", "R-PFA-1855183", "R-SSC-2151201", "R-BTA-611105", "R-XTR-77346", "R-HSA-9029558", "R-BTA-5365859", "R-RNO-77352", "R-HSA-5607763", "R-HSA-211945", "R-BTA-77111", "R-SCE-1614635", "R-SCE-1660661", "R-HSA-2029485", "R-RNO-75896", "R-RNO-193048", "R-SPO-156581", "R-HSA-9861718", "R-SCE-71336", "R-SSC-77310", "R-DRE-9757110", "R-BTA-9640463", "R-HSA-9818028", "R-DRE-9861718", "R-MMU-77108", "R-MMU-71064", "R-DDI-1855183", "R-SPO-75105", "R-SCE-8964572", "R-MMU-8866907", "R-RNO-2453902", "R-MMU-75105", "R-HSA-6807062", "R-HSA-611105", "R-DME-9018676", "R-SCE-70263", "R-BTA-70635", "R-DRE-70171", "R-SCE-196757", "R-SCE-2161541", "R-HSA-422356", "R-RNO-1614635", "R-HSA-71336", "R-CEL-5365859", "R-MMU-2161541", "R-MMU-70263", "R-CEL-5661270", "R-HSA-418457", "R-DME-71384", "R-BTA-9837999", "R-DDI-199220", "R-GGA-70268", "R-RNO-9013406", "R-RNO-6803204", "R-BTA-6799198", "R-MMU-6807062", "R-CFA-194002", "R-RNO-9018676", "R-MTU-879299", "R-RNO-3899300", "R-SCE-5365859", "R-DME-2142700", "R-DDI-5365859", "R-CEL-9837999", "R-RNO-5365859", "R-RNO-977347", "R-SSC-977347", "R-MMU-2453902", "R-MMU-5578775", "R-DME-70895", "R-DDI-77346", "R-MMU-77348", "R-DME-3769402", "R-DME-70268", "R-MMU-70370", "R-HSA-9918438", "R-HSA-77310", "R-CEL-173599", "R-GGA-5661270", "R-SSC-9856872", "R-MMU-390247", "R-RNO-9018896", "R-BTA-9707564", "R-GGA-71384", "R-RNO-1300642", "R-SPO-6807047", "R-SSC-193993", "R-RNO-77310", "R-MMU-203615", "R-MMU-77111", "R-HSA-2408508", "R-MMU-499943", "R-BTA-77108", "R-BTA-71384", "R-RNO-77350", "R-RNO-77288", "R-MMU-611105", "R-RNO-77348", "R-HSA-5578775", "R-HSA-77305", "R-SSC-8964539", "R-MMU-3769402", "R-SSC-77348", "R-HSA-390471", "R-CEL-1300642", "R-DME-9033241", "R-DME-9837999", "R-RNO-5652227", "R-CEL-70171", "R-DME-4641265", "R-MMU-9764725", "R-MMU-173599", "R-MMU-8964208", "R-CEL-1614635", "R-DME-193368", "R-RNO-8964208", "R-HSA-156581", "R-DME-70370", "R-MMU-1971475", "R-HSA-77108", "R-DRE-1971475", "R-HSA-2453902"], "pathways": ["R-GGA-5365859:r:RA biosynthesis pathway", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DRE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-SCE-156581:r:Methylation", "R-SCE-446199:r:Synthesis of dolichyl-phosphate", "R-DRE-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-71064:r:Lysine catabolism", "R-SCE-71384:r:Ethanol oxidation", "R-SSC-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DRE-8964539:r:Glutamate and glutamine metabolism", "R-CEL-2161541:r:Abacavir metabolism", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SPO-1614635:r:Sulfur amino acid metabolism", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-BTA-193993:r:Mineralocorticoid biosynthesis", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SPO-5365859:r:RA biosynthesis pathway", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-5652227:r:Fructose biosynthesis", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-SCE-70171:r:Glycolysis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-SSC-1482798:r:Acyl chain remodeling of CL", "R-MMU-1296052:r:Ca2+ activated K+ channels", "R-MMU-156581:r:Methylation", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SCE-71064:r:Lysine catabolism", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-RNO-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-5662853:r:Essential pentosuria", "R-SSC-5365859:r:RA biosynthesis pathway", "R-MMU-2187335:r:The retinoid cycle in cones (daylight vision)", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-CEL-6787639:r:GDP-fucose biosynthesis", "R-MMU-71336:r:Pentose phosphate pathway", "R-RNO-193993:r:Mineralocorticoid biosynthesis", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-2161541:r:Abacavir metabolism", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-DME-1483166:r:Synthesis of PA", "R-HSA-189483:r:Heme degradation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-1614635:r:Sulfur amino acid metabolism", "R-SPO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-SSC-194002:r:Glucocorticoid biosynthesis", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-GGA-2161541:r:Abacavir metabolism", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-DDI-70171:r:Glycolysis", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-RNO-71064:r:Lysine catabolism", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-SCE-70635:r:Urea cycle", "R-HSA-75876:r:Synthesis of very long-chain fatty 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"R-RNO-9757110:r:Prednisone ADME", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-HSA-9640463:r:Wax biosynthesis", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-MMU-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-DME-75896:r:Plasmalogen biosynthesis", "R-RNO-9640463:r:Wax biosynthesis", "R-MMU-70268:r:Pyruvate metabolism", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-70635:r:Urea cycle", "R-CEL-70263:r:Gluconeogenesis", "R-DME-8964539:r:Glutamate and glutamine metabolism", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-BTA-196757:r:Metabolism of folate and pterines", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2426168:r:Activation 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"R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-DME-425381:r:Bicarbonate transporters", "R-BTA-1296052:r:Ca2+ activated K+ channels", "R-BTA-9856872:r:Malate-aspartate shuttle", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-SCE-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SCE-5661270:r:Formation of xylulose-5-phosphate", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SCE-70370:r:Galactose catabolism", "R-RNO-77108:r:Utilization of Ketone Bodies", "R-HSA-71384:r:Ethanol oxidation", "R-DDI-6799198:r:Complex I biogenesis", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-GGA-70263:r:Gluconeogenesis", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-DDI-203615:r:eNOS activation", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-BTA-70263:r:Gluconeogenesis", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-HSA-70370:r:Galactose catabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-MMU-114608:r:Platelet degranulation", "R-DME-196757:r:Metabolism of folate and pterines", "R-HSA-9757110:r:Prednisone ADME", "R-RNO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-DME-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-XTR-1483166:r:Synthesis of PA", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-SPO-9856872:r:Malate-aspartate shuttle", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-8964208:r:Phenylalanine metabolism", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-CEL-1483166:r:Synthesis of PA", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-156581:r:Methylation", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-196757:r:Metabolism of folate and pterines", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-MMU-193144:r:Estrogen biosynthesis", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-DME-1614635:r:Sulfur amino acid metabolism", "R-SPO-70263:r:Gluconeogenesis", "R-MMU-71384:r:Ethanol oxidation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-DDI-8964539:r:Glutamate and glutamine metabolism", "R-XTR-193048:r:Androgen biosynthesis", "R-SCE-5628897:r:TP53 Regulates Metabolic Genes", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-DRE-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-8868766:r:rRNA processing in the mitochondrion", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-1489509:r:DAG and IP3 signaling", "R-DDI-70635:r:Urea cycle", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-5661270:r:Formation of xylulose-5-phosphate", "R-XTR-156581:r:Methylation", "R-HSA-9818025:r:NFE2L2 regulating TCA cycle genes", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-DME-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DRE-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-CEL-193144:r:Estrogen biosynthesis", "R-SPO-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-193144:r:Estrogen biosynthesis", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-SSC-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-RNO-71384:r:Ethanol oxidation", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-71336:r:Pentose phosphate pathway", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-SCE-9856872:r:Malate-aspartate shuttle", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-MMU-1483166:r:Synthesis of PA", "R-DRE-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-CEL-2187335:r:The retinoid cycle in cones (daylight vision)", "R-HSA-1296052:r:Ca2+ activated K+ channels", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-RNO-70370:r:Galactose catabolism", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-PFA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-SSC-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-XTR-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-BTA-5365859:r:RA biosynthesis pathway", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-BTA-77111:r:Synthesis of Ketone Bodies", "R-SCE-1614635:r:Sulfur amino acid metabolism", "R-SCE-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-75896:r:Plasmalogen biosynthesis", "R-RNO-193048:r:Androgen biosynthesis", "R-SPO-156581:r:Methylation", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-SCE-71336:r:Pentose phosphate pathway", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-DRE-9757110:r:Prednisone ADME", "R-BTA-9640463:r:Wax biosynthesis", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-MMU-77108:r:Utilization of Ketone Bodies", "R-MMU-71064:r:Lysine catabolism", "R-DDI-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-8964572:r:Lipid particle organization", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-HSA-611105:r:Respiratory electron transport", "R-DME-9018676:r:Biosynthesis of D-series resolvins", "R-SCE-70263:r:Gluconeogenesis", "R-BTA-70635:r:Urea cycle", "R-DRE-70171:r:Glycolysis", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SCE-2161541:r:Abacavir metabolism", "R-HSA-422356:r:Regulation of insulin secretion", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-HSA-71336:r:Pentose phosphate pathway", "R-CEL-5365859:r:RA biosynthesis pathway", "R-MMU-2161541:r:Abacavir metabolism", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-418457:r:cGMP effects", "R-DME-71384:r:Ethanol oxidation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-GGA-70268:r:Pyruvate metabolism", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-CFA-194002:r:Glucocorticoid biosynthesis", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-MTU-879299:r:Mycothiol biosynthesis", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-SCE-5365859:r:RA biosynthesis pathway", "R-DME-2142700:r:Biosynthesis of Lipoxins (LX)", "R-DDI-5365859:r:RA biosynthesis pathway", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-RNO-5365859:r:RA biosynthesis pathway", "R-RNO-977347:r:Serine metabolism", "R-SSC-977347:r:Serine metabolism", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-5578775:r:Ion homeostasis", "R-DME-70895:r:Branched-chain amino acid catabolism", "R-DDI-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-70268:r:Pyruvate metabolism", "R-MMU-70370:r:Galactose catabolism", "R-HSA-9918438:r:Defective visual phototransduction due to RDH5 loss of function", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-CEL-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-GGA-5661270:r:Formation of xylulose-5-phosphate", "R-SSC-9856872:r:Malate-aspartate shuttle", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-BTA-9707564:r:Cytoprotection by HMOX1", "R-GGA-71384:r:Ethanol oxidation", "R-RNO-1300642:r:Sperm Motility And Taxes", "R-SPO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-SSC-193993:r:Mineralocorticoid biosynthesis", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-203615:r:eNOS activation", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-BTA-77108:r:Utilization of Ketone Bodies", "R-BTA-71384:r:Ethanol oxidation", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-SSC-8964539:r:Glutamate and glutamine metabolism", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-CEL-1300642:r:Sperm Motility And Taxes", "R-DME-9033241:r:Peroxisomal protein import", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-5652227:r:Fructose biosynthesis", "R-CEL-70171:r:Glycolysis", "R-DME-4641265:r:Repression of WNT target genes", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-8964208:r:Phenylalanine metabolism", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-8964208:r:Phenylalanine metabolism", "R-HSA-156581:r:Methylation", "R-DME-70370:r:Galactose catabolism", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-77108:r:Utilization of Ketone Bodies", "R-DRE-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Homologous_superfamily"}, "IPR036292": {"description": "Proline/betaine transporter ProP, C-terminal", "go_ids": [], "go_terms": [], "name": "ProP_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, 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"R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-1170546:r:Prolactin receptor signaling", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-1170546:r:Prolactin receptor signaling", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8854050:r:FBXL7 down-regulates AURKA 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"R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Homologous_superfamily"}, "IPR036297": {"description": "PG0816-like superfamily", "go_ids": [], "go_terms": [], "name": "PG0816-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036298": {"description": "Chalcone isomerase superfamily", "go_ids": ["GO:0016872"], "go_terms": ["GO:0016872:intramolecular lyase activity:F"], "name": "Chalcone_isomerase_sf", "pathway_ids": ["PWY-7397", "PWY-7897", "PWY-5059", "PWY-2002", "PWY-6787", "PWY-6325"], "pathways": ["PWY-7397:t:naringenin biosynthesis (engineered)", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5059:t:pinobanksin biosynthesis", "PWY-2002:t:isoflavonoid biosynthesis I", "PWY-6787:t:flavonoid biosynthesis (in equisetum)", "PWY-6325:t:echinatin biosynthesis"], "type": "Homologous_superfamily"}, "IPR036299": {"description": "Polyketide synthase, docking domain superfmaily", "go_ids": [], "go_terms": [], "name": "Polyketide_synth_docking_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036300": {"description": "Mir domain superfamily", "go_ids": [], "go_terms": [], "name": "MIR_dom_sf", "pathway_ids": ["R-DRE-8932506", "R-MMU-139853", "R-HSA-139853", "R-DRE-9768727", "R-HSA-5607763", "R-CEL-983695", "R-HSA-8932504", "R-HSA-2672351", "R-HSA-1489509", "R-HSA-2029485", "R-DME-8932506", "R-DME-114508", "R-MMU-418457", "R-MMU-381676", "R-DRE-8932504", "R-RNO-2672351", "R-HSA-418457", "R-HSA-112043", "R-HSA-114508", "R-MMU-9717207", "R-MMU-2672351", 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"R-CEL-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-DME-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-418457:r:cGMP effects", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-4086398:r:Ca2+ pathway", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-DME-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-8932506:r:DAG1 core M1 glycosylations", "R-RNO-8932505:r:DAG1 core M3 glycosylations", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-8932506:r:DAG1 core M1 glycosylations", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-DME-5578775:r:Ion 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ARM", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-SSC-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SPO-418594:r:G alpha (i) signalling events", "R-DRE-416476:r:G alpha (q) signalling events", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-CFA-193648:r:NRAGE signals death through JNK", "R-CEL-4641257:r:Degradation of AXIN", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Homologous_superfamily"}, "IPR036306": {"description": "ISWI, HAND domain superfamily", "go_ids": ["GO:0003677", "GO:0031491", "GO:0006338"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0031491:nucleosome binding:F", "GO:0006338:chromatin remodeling:P"], "name": "ISWI_HAND-dom_sf", "pathway_ids": ["PWY-7250", "R-MMU-5693565", "R-HSA-606279", "R-MMU-606279", "R-MMU-5250924", "R-HSA-5693565", "R-HSA-427413", "R-HSA-5250924"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-MMU-5693565:r:Recruitment 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"R-XTR-4641258", "R-SPO-179409", "R-DDI-174048", "R-HSA-4641258", "R-CEL-9929491", "R-MMU-9705462", "R-MMU-9708530", "R-CEL-6781823", "R-HSA-180585", "R-HSA-1169091", "R-HSA-5658442", "R-HSA-2644607", "R-MMU-141430", "R-MMU-2871837", "R-DDI-141430", "R-DDI-68949", "R-DME-5610785", "R-MMU-6782210", "R-DME-5607764", "R-RNO-983168", "R-DME-2871837", "R-HSA-110314", "R-DDI-176408", "R-DDI-6782135", "R-MMU-8863795", "R-HSA-8853884", "R-MMU-5610780", "R-HSA-187577", "R-DME-1169091", "R-CEL-8863795", "R-XTR-5632684", "R-DDI-9755511", "R-MMU-6782135", "R-SPO-176408", "R-DME-5610780", "R-XTR-9013422", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-2559582", "R-HSA-174184", "R-MMU-9954709", "R-DME-195253", "R-MMU-174048", "R-MMU-69601", "R-HSA-2565942", "R-HSA-2871837", "R-MMU-5610785", "R-HSA-9954709", "R-DME-5607761", "R-MMU-8854050", "R-SPO-983168", "R-MMU-5658442", "R-SCE-983168", "R-HSA-174084", "R-HSA-176407", "R-HSA-5607764", "R-DME-68949", "R-DDI-69017", "R-MMU-1170546", "R-CEL-9954709", "R-RNO-9929491", "R-HSA-9706019", "R-HSA-2894862", "R-RNO-9706019", "R-HSA-69601", "R-HSA-9679191", "R-HSA-983168", "R-HSA-6782135", "R-HSA-5632684", "R-MMU-176407", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-XTR-983168", "R-SPO-5696400", "R-XTR-9755511", "R-RNO-5658442", "R-HSA-917937", "R-HSA-9705462", "R-HSA-69017", "R-MMU-983168", "R-SPO-6782135", "R-HSA-202424", "R-DDI-174154"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-69231:r:Cyclin D associated events in G1", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-917937:r:Iron uptake and transport", "R-XTR-9013418:r:RHOBTB2 GTPase cycle", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-CEL-69231:r:Cyclin D associated events in G1", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-XTR-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-8951664:r:Neddylation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-SCE-917937:r:Iron uptake and transport", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-68949:r:Orc1 removal from chromatin", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-68949:r:Orc1 removal from chromatin", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-917937:r:Iron uptake and transport", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-9706019:r:RHOBTB3 ATPase cycle", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-917937:r:Iron uptake and transport", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-69231:r:Cyclin D associated events in G1", "R-XTR-8951664:r:Neddylation", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-9020702:r:Interleukin-1 signaling", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-8951664:r:Neddylation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-69231:r:Cyclin D associated events in G1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5632684:r:Hedgehog 'on' state", "R-MMU-8951664:r:Neddylation", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-4641258:r:Degradation of DVL", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-XTR-4641258:r:Degradation of DVL", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-XTR-5632684:r:Hedgehog 'on' state", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-XTR-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-68949:r:Orc1 removal from chromatin", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-68949:r:Orc1 removal from chromatin", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-XTR-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin"], "type": "Homologous_superfamily"}, "IPR036318": {"description": "FAD-binding, type PCMH-like superfamily", "go_ids": ["GO:0050660"], "go_terms": ["GO:0050660:flavin adenine dinucleotide binding:F"], "name": "FAD-bd_PCMH-like_sf", "pathway_ids": ["R-MMU-9837999", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", "R-RNO-74259", "R-DME-964975", "R-CEL-75896", "R-RNO-75896", "R-MMU-9969901", "R-SCE-880009", "R-MMU-75896", "R-RNO-9033241", "R-HSA-6807047", "R-MMU-6807047", "R-HSA-74259", "R-HSA-1268020", "R-DME-74259", "R-HSA-75896", "R-MMU-964975", "R-BTA-880009", "R-DME-9748787", "R-MMU-1268020", "R-HSA-9837999", "R-RNO-9748787", "R-MMU-6807062", "R-DME-75896", "R-MMU-9748787", "R-RNO-8851680", "R-DRE-880009", "R-HSA-9969901", "R-DRE-1268020", "R-RNO-6807062", "R-DME-9033241", "R-GGA-421178", "R-MMU-9033241", "R-HSA-6807062", "R-RNO-9969901", "R-DRE-9837999", "R-CEL-6807062", "R-MMU-8851680", "R-SPO-880009", "R-HSA-9748787", "R-HSA-880009", "R-MMU-880009", "R-RNO-964975", "R-CEL-6807047", "R-SCE-9837999", "R-CEL-964975", "R-MMU-74259", "R-DDI-964975", "R-HSA-9033500", "R-RNO-6807047", "R-HSA-9033241", "R-RNO-880009", "R-DDI-74259", "R-CEL-9969901"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-75896:r:Plasmalogen biosynthesis", "R-RNO-75896:r:Plasmalogen biosynthesis", "R-MMU-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-SCE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-75896:r:Plasmalogen biosynthesis", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-MMU-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-HSA-74259:r:Purine catabolism", "R-HSA-1268020:r:Mitochondrial protein import", "R-DME-74259:r:Purine catabolism", "R-HSA-75896:r:Plasmalogen biosynthesis", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-1268020:r:Mitochondrial protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9748787:r:Azathioprine ADME", "R-MMU-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-DME-75896:r:Plasmalogen biosynthesis", "R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-DRE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-DRE-1268020:r:Mitochondrial protein import", "R-RNO-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-DME-9033241:r:Peroxisomal protein import", "R-GGA-421178:r:Urate synthesis", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-RNO-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-CEL-6807062:r:Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-SPO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-RNO-6807047:r:Cholesterol biosynthesis via desmosterol (Bloch pathway)", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DDI-74259:r:Purine catabolism", "R-CEL-9969901:r:Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "type": "Homologous_superfamily"}, "IPR036319": {"description": "RDM1 superfamily", "go_ids": [], "go_terms": [], "name": "RDM1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036320": {"description": "Glycosyl transferase family 3, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Glycosyl_Trfase_fam3_N_dom_sf", "pathway_ids": ["R-RNO-73621", "R-MMU-73614", "R-HSA-73621", "R-HSA-73614", "R-MMU-73621", "R-RNO-73614"], "pathways": ["R-RNO-73621:r:Pyrimidine catabolism", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-73614:r:Pyrimidine salvage"], "type": "Homologous_superfamily"}, "IPR036321": {"description": "Hypothetical protein ST1625", "go_ids": [], "go_terms": [], "name": "ST1625", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036322": {"description": "WD40-repeat-containing domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "WD40_repeat_dom_sf", "pathway_ids": ["R-HSA-6782135", "R-HSA-9679191", "R-RNO-1296041", "R-DDI-983168", "R-HSA-418594", "R-CEL-69601", "R-HSA-9929356", "R-BTA-8854518", "R-DRE-674695", "R-MMU-983168", "R-BTA-159236", "R-MMU-9696270", "R-SPO-6791226", "R-RNO-9861718", "R-DRE-6811436", "R-CEL-73779", "R-MMU-8856828", "R-HSA-9646399", "R-HSA-73772", "R-SPO-674695", "R-MMU-381771", "R-SCE-204005", "R-SCE-3214847", "R-RNO-72163", "R-DME-72163", "R-DRE-2467813", "R-MMU-68877", "R-MMU-2559584", "R-SSC-174184", "R-CEL-418555", "R-SCE-6791226", "R-CEL-4086398", "R-CEL-9772755", "R-DME-75953", "R-CFA-4086398", "R-MMU-9930044", "R-SPO-2029482", "R-HSA-168138", "R-MMU-3301854", "R-HSA-418555", "R-HSA-72706", "R-MMU-111458", "R-XTR-4085377", "R-MMU-170822", "R-RNO-5663220", "R-MMU-171319", "R-DME-5218920", "R-BTA-6811436", "R-HSA-6804756", "R-DDI-5674135", "R-RNO-4570464", "R-HSA-180534", "R-MMU-9696264", "R-MMU-392170", "R-HSA-194138", "R-DDI-72689", "R-BTA-381753", "R-BTA-6804758", "R-DDI-5696395", "R-HSA-191859", "R-DRE-2485179", "R-RNO-1257604", "R-RNO-174178", "R-DME-2565942", "R-DDI-6811434", "R-MMU-5357956", "R-MMU-174178", "R-MMU-418594", "R-DRE-9627069", "R-RNO-418594", "R-XTR-5696395", "R-DME-73776", "R-HSA-9907900", "R-BTA-381771", "R-CEL-3108214", "R-DDI-418594", "R-HSA-6782210", "R-MMU-9841922", "R-DME-111459", "R-HSA-9627069", "R-MMU-5693579", "R-DME-9037629", "R-MMU-159231", "R-HSA-9701192", "R-HSA-195253", "R-CEL-69273", "R-MMU-3214847", "R-XTR-191859", "R-DRE-9646399", "R-BTA-72165", "R-HSA-109704", "R-MMU-1257604", "R-BTA-674695", "R-RNO-111459", "R-DME-3301854", "R-MMU-174184", "R-HSA-75955", "R-DRE-2565942", "R-RNO-159231", "R-MMU-2485179", "R-RNO-432040", "R-BTA-9639288", "R-GGA-380284", "R-XTR-6791226", "R-MMU-9013106", "R-DRE-3232142", "R-RNO-392170", "R-DRE-4551638", "R-RNO-5357905", "R-HSA-6796648", "R-HSA-9841922", "R-MMU-381676", "R-RNO-380320", "R-MMU-72706", "R-RNO-111458", "R-HSA-3371453", "R-DME-3371571", "R-HSA-202040", "R-RNO-9772755", "R-HSA-9933387", "R-DRE-9013407", "R-HSA-8943724", "R-BTA-5620912", "R-SPO-176407", "R-HSA-420092", "R-HSA-1296041", "R-BTA-204005", "R-XTR-69601", "R-DME-6807878", "R-DRE-9018519", "R-DME-209413", "R-SSC-176407", "R-BTA-156827", "R-SCE-6811434", "R-BTA-2559580", "R-HSA-9918432", "R-DDI-69656", "R-BTA-73856", "R-XTR-112382", "R-HSA-2029482", "R-MMU-2559580", "R-MMU-6807505", "R-RNO-174184", "R-BTA-9615933", "R-BTA-177929", "R-BTA-9770562", "R-HSA-428930", "R-MMU-2173788", "R-MMU-1660517", "R-RNO-2514859", "R-SCE-6782135", "R-SCE-76066", "R-HSA-9930044", "R-SPO-159231", "R-HSA-9704646", "R-DME-159231", "R-RNO-109704", "R-RNO-2173788", "R-DME-9013424", "R-HSA-8953750", "R-RNO-1660514", "R-HSA-6811440", "R-HSA-171319", "R-HSA-6804758", "R-HSA-5610787", "R-MMU-2514859", "R-HSA-525793", "R-HSA-176407", "R-DME-450728", "R-BTA-392451", "R-MMU-2995383", "R-DDI-69017", "R-MMU-6814122", "R-DME-209190", "R-SSC-3232142", "R-BTA-159230", "R-HSA-168276", "R-XTR-212300", "R-HSA-2894862", "R-DDI-1660516", "R-CFA-9009391", "R-CFA-9717207", "R-XTR-380284", "R-RNO-381676", "R-SSC-2467813", "R-RNO-4086398", "R-DRE-9615933", "R-DME-209440", "R-CEL-9764725", "R-BTA-428930", "R-HSA-9843940", "R-DRE-110314", "R-SSC-2500257", "R-HSA-380259", "R-HSA-69202", "R-XTR-2500257", "R-RNO-202040", "R-HSA-392451", "R-RNO-6781823", "R-BTA-392170", "R-SCE-9772755", "R-MMU-4086398", "R-CFA-8964616", "R-MMU-69017", "R-RNO-9009391", "R-SSC-191859", "R-SCE-114608", "R-RNO-5610787", "R-DRE-111458", "R-BTA-606279", "R-MMU-112382", "R-DDI-179409", "R-BTA-8964315", "R-DDI-141405", "R-RNO-73856", "R-XTR-141444", "R-DDI-5213460", "R-HSA-427359", "R-RNO-380284", "R-DDI-5218920", "R-DDI-5673000", "R-DME-5610787", "R-DRE-5663220", "R-DDI-176407", "R-MMU-5620912", "R-DME-9648025", "R-BTA-5626978", "R-HSA-429947", "R-HSA-416482", "R-HSA-400042", "R-CEL-6782210", "R-DME-9861718", "R-MMU-1296041", "R-HSA-9696264", "R-RNO-6811436", "R-SSC-179409", "R-DRE-5357905", "R-BTA-432040", "R-MMU-193648", "R-MMU-6804758", "R-HSA-9013026", "R-DME-389357", "R-SPO-72689", "R-SCE-73776", "R-BTA-191859", "R-SCE-1660516", "R-RNO-4615885", "R-XTR-8936459", "R-HSA-5610785", "R-HSA-6811438", "R-DDI-165159", "R-DME-2995383", "R-MMU-983189", "R-CEL-9907900", "R-HSA-9013106", "R-DME-73779", "R-CEL-983168", "R-HSA-6790901", "R-HSA-159227", "R-DME-9907900", "R-CEL-5610787", "R-DME-111458", "R-SSC-174154", "R-HSA-4086398", "R-MMU-5626978", "R-SPO-6804757", "R-DRE-9717207", "R-XTR-1538133", "R-DME-3108214", "R-MMU-202424", "R-HSA-176412", "R-HSA-381038", "R-MMU-109704", "R-DME-6811436", "R-MMU-176417", "R-RNO-392451", "R-RNO-430039", "R-XTR-8951664", "R-CEL-9615933", "R-HSA-350054", "R-MMU-156827", "R-SPO-9033241", "R-DME-3214847", "R-XTR-9639288", "R-CEL-392170", "R-HSA-5693579", "R-SPO-72163", "R-SPO-8876198", "R-BTA-9856530", "R-HSA-8964315", "R-CEL-3371453", "R-SCE-5218920", "R-HSA-73779", "R-CEL-6811434", "R-BTA-983168", "R-SPO-6807878", "R-SSC-174048", "R-HSA-112382", "R-XTR-110314", "R-CEL-975957", "R-RNO-983189", "R-SPO-6814122", "R-DME-6781823", "R-DRE-201722", "R-MMU-201722", "R-DRE-8951664", "R-MMU-9639288", "R-DDI-9646399", "R-SSC-3301854", "R-MMU-76066", "R-CEL-416482", "R-DRE-3214815", "R-SPO-5663213", "R-BTA-380259", "R-HSA-159230", "R-CEL-6811440", "R-MMU-5668599", "R-HSA-177929", "R-HSA-174113", "R-CEL-6791226", "R-SSC-176417", "R-GGA-5696400", "R-MMU-73779", "R-DRE-9764725", "R-SPO-75953", "R-HSA-430039", "R-RNO-975957", "R-MMU-8936459", "R-HSA-176409", "R-HSA-9821993", "R-DME-3371453", "R-SSC-176409", "R-DRE-72695", "R-DME-209441", "R-HSA-9755511", "R-HSA-9648025", "R-RNO-8964616", "R-MMU-674695", "R-DME-1296041", "R-SPO-77595", "R-MMU-9018519", "R-GGA-141444", "R-HSA-3301854", "R-RNO-1660517", "R-XTR-9930044", "R-HSA-381676", "R-SPO-9013424", "R-SPO-156827", "R-BTA-9766229", "R-CEL-5620922", "R-DME-156827", "R-CFA-9634597", "R-DRE-159231", "R-SSC-68877", "R-BTA-4570464", "R-SSC-174178", "R-RNO-5620912", "R-RNO-72689", "R-BTA-3214858", "R-RNO-212300", "R-CFA-420092", "R-CEL-1538133", "R-CEL-8876198", "R-HSA-9833110", "R-DRE-9856530", "R-SPO-1257604", "R-CEL-3214847", "R-BTA-380284", "R-BTA-212300", "R-XTR-72695", "R-GGA-429947", "R-GGA-6811436", "R-RNO-6811434", "R-RNO-73772", "R-HSA-390471", "R-HSA-6807878", "R-RNO-2485179", "R-RNO-5250924", "R-GGA-380320", "R-MMU-9764725", "R-DRE-392170", "R-MMU-418592", "R-BTA-983170", "R-MMU-176407", "R-CFA-8964315", "R-DME-8936459", "R-XTR-2565942", "R-DRE-416476", "R-SCE-5668599", "R-DDI-174178", "R-RNO-141405", "R-HSA-163615", "R-MMU-8857538", "R-DME-6814122", "R-HSA-9696273", "R-DRE-418597", "R-HSA-5626978", "R-BTA-5689880", "R-MMU-9770562", "R-RNO-9018519", "R-DME-5696394", "R-MMU-1538133", "R-HSA-69656", "R-CFA-456926", "R-MMU-5610787", "R-SCE-1660517", "R-XTR-5610787", "R-SPO-4085377", "R-HSA-749476", "R-SSC-4615885", "R-CEL-73776", "R-HSA-111463", "R-SCE-9696273", "R-MMU-8866654", "R-DDI-6798695", "R-DME-9772755", "R-HSA-3247509", "R-DRE-429958", "R-HSA-9710421", "R-CEL-674695", "R-HSA-72163", "R-SCE-1632852", "R-CFA-418594", "R-RNO-9764725", "R-SSC-159230", "R-DDI-5696394", "R-RNO-3232142", "R-HSA-179409", "R-DRE-5607761", "R-DDI-1660514", "R-BTA-9648025", "R-HSA-9609736", "R-CFA-997272", "R-RNO-380270", "R-BTA-6811434", "R-RNO-141444", "R-DDI-9013418", "R-HSA-9634597", "R-DME-202424", "R-MMU-5674135", "R-SPO-159227", "R-DME-72649", "R-SSC-159227", "R-DRE-8953750", "R-XTR-8854518", "R-XTR-72702", "R-DDI-3214847", "R-RNO-9860927", "R-MMU-349425", "R-CEL-77595", "R-DME-9770562", "R-HSA-114608", "R-RNO-168138", "R-HSA-500657", 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"R-DME-5696395", "R-MMU-176412", "R-MMU-6783310", "R-GGA-5689880", "R-HSA-983170", "R-XTR-9909649", "R-HSA-674695", "R-DDI-156827", "R-MMU-418555", "R-CEL-8951664", "R-SSC-5663220", "R-MMU-1660516", "R-SCE-1660514", "R-HSA-9932298", "R-HSA-69273", "R-DME-380972", "R-BTA-202040", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-159230", "R-MMU-8951664", "R-DDI-5675482", "R-RNO-174154", "R-MMU-392451", "R-GGA-9648025", "R-CEL-8964616", "R-CEL-204005", "R-XTR-5689880", "R-SSC-3108214", "R-HSA-1266695", "R-HSA-111459", "R-HSA-606279", "R-RNO-141430", "R-DRE-418594", "R-SPO-72706", "R-HSA-9687136", "R-DME-159227", "R-SPO-141405", "R-RNO-73762", "R-HSA-1660516", "R-HSA-6811558", "R-HSA-204005", "R-RNO-112382", "R-RNO-2467813", "R-DME-5607764", "R-HSA-1257604", "R-DME-209421", "R-DME-8943724", "R-HSA-2132295", "R-RNO-983170", "R-RNO-176417", "R-RNO-2500257", "R-CFA-400042", "R-CEL-72702", "R-BTA-5663220", "R-CEL-416476", "R-RNO-176407", "R-MMU-72649", "R-RNO-5663213", "R-MMU-4085377", "R-HSA-9636383", "R-CEL-6811438", "R-SCE-983168", "R-SCE-9013424", "R-SPO-69273", "R-GGA-2467813", "R-BTA-73762", "R-MMU-2500257", "R-DRE-428930", "R-MMU-500657", "R-DME-8876198", "R-HSA-4085377", "R-HSA-69601", "R-HSA-983168", "R-CFA-428930", "R-MMU-9033241", "R-DDI-3371571", "R-MMU-2029482", "R-SCE-3214815", "R-DDI-8943724", "R-SCE-72649", "R-DRE-3301854", "R-DRE-72689", "R-DRE-430039", "R-HSA-5250924", "R-HSA-165159", "R-BTA-418217", "R-XTR-5620924", "R-HSA-202424", "R-HSA-9033241", "R-HSA-5663213", "R-DME-110314", "R-HSA-9020702", "R-HSA-9022692", "R-HSA-168638", "R-MMU-1266695", "R-RNO-3301854", "R-MMU-3214815", "R-MMU-606279", "R-SPO-975957", "R-BTA-400042", "R-MMU-75955", "R-MMU-9615933", "R-CFA-381771", "R-XTR-606279", "R-HSA-6811434", "R-RNO-6811558", "R-CFA-392170", "R-DRE-6814122", "R-DRE-381676", "R-MMU-141405", "R-CEL-69231", "R-DDI-9033241", "R-MMU-174084", "R-DME-6782135", "R-SCE-72702", "R-BTA-72163", "R-SCE-76061", "R-BTA-6791226", "R-CFA-392451", "R-RNO-9717207", "R-CEL-6807878", "R-BTA-4551638", "R-MMU-2559582", "R-HSA-9609690", "R-HSA-6783310", "R-DDI-392451", "R-HSA-159231", "R-MMU-69656", "R-RNO-4085377", "R-RNO-8951664", "R-MMU-983170", "R-RNO-6798695", "R-HSA-5620922", "R-CEL-72689", "R-BTA-2029482", "R-SPO-3371453", "R-HSA-9705671", "R-DME-429947", "R-MMU-72689", "R-MMU-179409", "R-XTR-3214847", "R-RNO-3371497", "R-MMU-380284", "R-BTA-8964616", "R-DME-3214815", "R-HSA-77595", "R-MMU-6781823", "R-SSC-4085377", "R-DME-3214858", "R-SPO-69656", "R-HSA-68877", "R-CFA-418592", "R-DDI-2467813", "R-CFA-168638", "R-HSA-72165", "R-DDI-176412", "R-MMU-73776", "R-SPO-429958", "R-DRE-212300", "R-MMU-191859", "R-SSC-3371453", "R-DDI-2029482", "R-CEL-2485179", "R-BTA-456926", "R-MMU-975957", "R-DDI-5663213", "R-XTR-3371453", "R-HSA-2995383", "R-SPO-6811440", "R-GGA-5696394", "R-BTA-9009391", "R-RNO-69273", "R-RNO-380259", "R-RNO-69231", "R-HSA-73863", "R-XTR-3214815", "R-RNO-3214847", "R-MMU-9909649", "R-DDI-174184", "R-MMU-72165", "R-DRE-72702", "R-HSA-9818564", "R-HSA-9733709", "R-DME-5696400", "R-HSA-3371571", "R-RNO-9646399", "R-MMU-9013149", "R-DME-9856530", "R-DRE-72165", "R-MMU-9707564", "R-CEL-159231", "R-MMU-8964315", "R-HSA-5674135", "R-BTA-3214815", "R-SCE-75953", "R-SCE-6814122", "R-RNO-3214858", "R-DRE-8943724", "R-HSA-380284", "R-HSA-9013424", "R-HSA-8854518", "R-HSA-1368108", "R-RNO-72695", "R-RNO-191859", "R-SPO-9696273", "R-DRE-3214847", "R-CFA-202040", "R-HSA-9018519", "R-HSA-68867", "R-MMU-381753", "R-HSA-2514859", "R-DDI-72695", "R-XTR-6804758", "R-MMU-73856", "R-HSA-3214815", "R-HSA-111458", "R-HSA-168325", "R-HSA-2465910", "R-HSA-2644607", "R-DME-72165", "R-HSA-9704331", "R-HSA-5619107", "R-HSA-5693554", "R-CEL-997272", "R-DME-5628897", "R-HSA-9679504", "R-BTA-8951664", "R-MMU-6782135", "R-CEL-400042", "R-RNO-9696270", "R-HSA-349425", "R-MMU-429958", "R-DME-159236", "R-HSA-2559582", "R-HSA-1169408", "R-CEL-6814122", "R-DRE-159236", "R-HSA-168333", "R-XTR-5620912", "R-BTA-2467813", "R-SSC-5689880", "R-BTA-997272", "R-SCE-176407", "R-SCE-6782210", "R-HSA-9918481", "R-DME-418597", "R-BTA-8943724", "R-SPO-72649", "R-HSA-1362300", "R-SCE-2559584", "R-HSA-111464"], "pathways": ["R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-3214847:r:HATs acetylate histones", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-CEL-418555:r:G alpha (s) signalling events", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-4086398:r:Ca2+ pathway", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-CFA-4086398:r:Ca2+ pathway", "R-MMU-9930044:r:Nuclear RNA decay", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-111458:r:Formation of apoptosome", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-392170:r:ADP signalling through P2Y purinoceptor 12", "R-HSA-194138:r:Signaling by VEGF", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-BTA-381753:r:Olfactory Signaling Pathway", "R-BTA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-191859:r:snRNP Assembly", "R-DRE-2485179:r:Activation of the phototransduction cascade", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-418594:r:G alpha (i) signalling events", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-RNO-418594:r:G alpha (i) signalling events", "R-XTR-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9907900:r:Proteasome assembly", "R-BTA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-418594:r:G alpha (i) signalling events", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DME-9037629:r:Lewis blood group biosynthesis", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-3214847:r:HATs acetylate histones", "R-XTR-191859:r:snRNP Assembly", "R-DRE-9646399:r:Aggrephagy", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-GGA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-9013106:r:RHOC GTPase cycle", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-392170:r:ADP signalling through P2Y purinoceptor 12", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-111458:r:Formation of apoptosome", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-202040:r:G-protein activation", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-DRE-9013407:r:RHOH GTPase cycle", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SPO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-420092:r:Glucagon-type ligand receptors", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-XTR-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-SSC-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-177929:r:Signaling by EGFR", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-9930044:r:Nuclear RNA decay", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-109704:r:PI3K Cascade", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-525793:r:Myogenesis", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DME-450728:r:Inhibition of actin polymerization", "R-BTA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-209190:r:Phosphorylation of CI", "R-SSC-3232142:r:SUMOylation of ubiquitinylation proteins", "R-BTA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-RNO-4086398:r:Ca2+ pathway", "R-DRE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-428930:r:Thromboxane signalling through TP receptor", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-202040:r:G-protein activation", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-4086398:r:Ca2+ pathway", "R-CFA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-191859:r:snRNP Assembly", "R-SCE-114608:r:Platelet degranulation", "R-RNO-5610787:r:Hedgehog 'off' state", "R-DRE-111458:r:Formation of apoptosome", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-8964315:r:G beta:gamma signalling through BTK", "R-DDI-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-5673000:r:RAF activation", "R-DME-5610787:r:Hedgehog 'off' state", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-191859:r:snRNP Assembly", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-XTR-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DDI-165159:r:MTOR signalling", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-983189:r:Kinesins", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-9907900:r:Proteasome assembly", "R-CEL-5610787:r:Hedgehog 'off' state", "R-DME-111458:r:Formation of apoptosome", "R-SSC-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-DRE-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-XTR-1538133:r:G0 and Early G1", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-109704:r:PI3K Cascade", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-176417:r:Phosphorylation of Emi1", "R-RNO-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-XTR-8951664:r:Neddylation", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-9033241:r:Peroxisomal protein import", "R-DME-3214847:r:HATs acetylate histones", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-CEL-392170:r:ADP signalling through P2Y purinoceptor 12", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-SSC-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-XTR-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-983189:r:Kinesins", "R-SPO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-8951664:r:Neddylation", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-DDI-9646399:r:Aggrephagy", "R-SSC-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-DRE-3214815:r:HDACs deacetylate histones", "R-SPO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-176417:r:Phosphorylation of Emi1", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SSC-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-209441:r:WG ligand not bound to FZ receptors", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-1296041:r:Activation of G protein gated Potassium channels", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-XTR-9930044:r:Nuclear RNA decay", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9766229:r:Degradation of CDH1", "R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CFA-9634597:r:GPER1 signaling", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SSC-68877:r:Mitotic Prometaphase", "R-BTA-4570464:r:SUMOylation of RNA binding proteins", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-CFA-420092:r:Glucagon-type ligand receptors", "R-CEL-1538133:r:G0 and Early G1", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9833110:r:RSV-host interactions", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-CEL-3214847:r:HATs acetylate histones", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-GGA-429947:r:Deadenylation of mRNA", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-392170:r:ADP signalling through P2Y purinoceptor 12", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-CFA-8964315:r:G beta:gamma signalling through BTK", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-416476:r:G alpha (q) signalling events", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-HSA-163615:r:PKA activation", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-418597:r:G alpha (z) signalling events", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CFA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-5610787:r:Hedgehog 'off' state", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-XTR-5610787:r:Hedgehog 'off' state", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SSC-4615885:r:SUMOylation of DNA replication proteins", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-SCE-9696273:r:RND1 GTPase cycle", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3247509:r:Chromatin modifying enzymes", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9710421:r:Defective pyroptosis", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-1632852:r:Macroautophagy", "R-CFA-418594:r:G alpha (i) signalling events", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SSC-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9634597:r:GPER1 signaling", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-72649:r:Translation initiation complex formation", "R-SSC-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-3214847:r:HATs acetylate histones", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-BTA-4615885:r:SUMOylation of DNA replication proteins", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-3214847:r:HATs acetylate histones", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9696273:r:RND1 GTPase cycle", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-9907900:r:Proteasome assembly", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-HSA-381753:r:Olfactory Signaling Pathway", 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components", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-3295583:r:TRP channels", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-5626978:r:TNFR1-mediated ceramide production", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-983189:r:Kinesins", "R-SCE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-DRE-4641265:r:Repression of WNT target genes", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-DRE-202040:r:G-protein activation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-CFA-418217:r:G beta:gamma signalling through PLC beta", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-BTA-3214841:r:PKMTs methylate histone lysines", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-1632852:r:Macroautophagy", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-3214815:r:HDACs deacetylate histones", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-5610787:r:Hedgehog 'off' state", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-9033241:r:Peroxisomal protein import", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-SSC-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-DME-114608:r:Platelet degranulation", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-420092:r:Glucagon-type ligand receptors", "R-RNO-72649:r:Translation initiation complex formation", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-167161:r:HIV Transcription Initiation", "R-MMU-9646399:r:Aggrephagy", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-DME-432620:r:Dephosphorylation of PER", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-418597:r:G alpha (z) signalling events", "R-CEL-418597:r:G alpha (z) signalling events", "R-CFA-416476:r:G alpha (q) signalling events", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate 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"R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-BTA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DME-9646399:r:Aggrephagy", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon 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"R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-DME-9930044:r:Nuclear RNA decay", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-MMU-202040:r:G-protein activation", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DRE-1538133:r:G0 and Early G1", "R-CEL-4641265:r:Repression of WNT target genes", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-9696273:r:RND1 GTPase cycle", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-429947:r:Deadenylation of mRNA", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-6791226:r:Major 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"R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-3214815:r:HDACs deacetylate histones", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-4641265:r:Repression of WNT target genes", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-CEL-418594:r:G alpha (i) signalling events", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-75953:r:RNA Polymerase II 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"R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-BTA-418555:r:G alpha (s) signalling events", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-CEL-1296041:r:Activation of G protein gated Potassium channels", "R-SPO-429947:r:Deadenylation of mRNA", "R-GGA-8854518:r:AURKA Activation by TPX2", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-CEL-1632852:r:Macroautophagy", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-416476:r:G alpha (q) signalling events", "R-SPO-3214847:r:HATs acetylate histones", "R-CFA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DRE-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-XTR-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-RNO-6782135:r:Dual incision in TC-NER", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-XTR-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-XTR-68877:r:Mitotic Prometaphase", "R-DME-4641265:r:Repression of WNT target genes", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-SCE-9907900:r:Proteasome assembly", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-166208:r:mTORC1-mediated signalling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CFA-1296041:r:Activation of G protein gated Potassium channels", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-HSA-176417:r:Phosphorylation of Emi1", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-XTR-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8951664:r:Neddylation", "R-MMU-1632852:r:Macroautophagy", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-XTR-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CFA-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-CEL-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-416476:r:G alpha (q) signalling events", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9634597:r:GPER1 signaling", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-BTA-418597:r:G alpha (z) signalling events", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-SSC-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-XTR-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-165159:r:MTOR signalling", "R-SSC-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-166208:r:mTORC1-mediated signalling", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-429947:r:Deadenylation of mRNA", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-69231:r:Cyclin D associated events in G1", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-GGA-5689880:r:Ub-specific processing proteases", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-418555:r:G alpha (s) signalling events", "R-CEL-8951664:r:Neddylation", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-202040:r:G-protein activation", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-8951664:r:Neddylation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-XTR-5689880:r:Ub-specific processing proteases", "R-SSC-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-RNO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DRE-418594:r:G alpha (i) signalling events", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-209421:r:Transcription activation by ARM", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-176417:r:Phosphorylation of Emi1", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CFA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-CEL-416476:r:G alpha (q) signalling events", "R-RNO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-72649:r:Translation initiation complex formation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-CEL-6811438:r:Intra-Golgi traffic", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9013424:r:RHOV GTPase cycle", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-428930:r:Thromboxane signalling through TP receptor", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-3214815:r:HDACs deacetylate histones", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-165159:r:MTOR signalling", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "R-XTR-5620924:r:Intraflagellar transport", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-1266695:r:Interleukin-7 signaling", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-3214815:r:HDACs deacetylate histones", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CFA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-XTR-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CFA-392170:r:ADP signalling through P2Y purinoceptor 12", "R-DRE-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DRE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-CEL-69231:r:Cyclin D associated events in G1", "R-DDI-9033241:r:Peroxisomal protein import", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-RNO-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-BTA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DDI-392451:r:G beta:gamma signalling through PI3Kgamma", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-8951664:r:Neddylation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DME-429947:r:Deadenylation of mRNA", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-XTR-3214847:r:HATs acetylate histones", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-DME-3214815:r:HDACs deacetylate histones", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-4085377:r:SUMOylation of SUMOylation proteins", "R-DME-3214858:r:RMTs methylate histone arginines", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-68877:r:Mitotic Prometaphase", "R-CFA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-MMU-191859:r:snRNP Assembly", "R-SSC-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2485179:r:Activation of the phototransduction cascade", "R-BTA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-GGA-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-XTR-3214815:r:HDACs deacetylate histones", "R-RNO-3214847:r:HATs acetylate histones", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-9733709:r:Cardiogenesis", "R-DME-5696400:r:Dual Incision in GG-NER", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-RNO-9646399:r:Aggrephagy", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-BTA-3214815:r:HDACs deacetylate histones", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-DRE-8943724:r:Regulation of PTEN gene transcription", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-191859:r:snRNP Assembly", "R-SPO-9696273:r:RND1 GTPase cycle", "R-DRE-3214847:r:HATs acetylate histones", "R-CFA-202040:r:G-protein activation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-381753:r:Olfactory Signaling Pathway", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-CEL-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-SSC-5689880:r:Ub-specific processing proteases", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-SCE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-418597:r:G alpha (z) signalling events", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-SPO-72649:r:Translation initiation complex formation", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes"], "type": "Homologous_superfamily"}, "IPR036323": {"description": "Chemokine-binding M3 superfamily", "go_ids": [], "go_terms": [], "name": "M3_sf_vir", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036324": {"description": "Manganese/iron superoxide dismutase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Mn/Fe_SOD_N_sf", "pathway_ids": ["PWY-6854", "R-DDI-3299685", "R-HSA-3299685", "R-SCE-3299685", "R-HSA-9615017", "R-HSA-2151201", "R-SPO-3299685", "R-RNO-3299685", "R-RNO-2151201", "R-HSA-9841251", "R-HSA-8950505", "R-HSA-8862803", "R-HSA-1222387", "R-CEL-3299685", "R-DME-3299685", "R-MMU-3299685", "R-MMU-2151201"], "pathways": ["PWY-6854:t:ethene biosynthesis III (microbes)", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis"], "type": "Homologous_superfamily"}, "IPR036325": {"description": "Bacteriophage PRD1, P2, absorption protein superfamily", "go_ids": [], "go_terms": [], "name": "P2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036326": {"description": "Spike S1 subunit, receptor binding domain superfamily, betacoronavirus", "go_ids": [], "go_terms": [], "name": "Spike_S1_RBD_sf_bCoV", "pathway_ids": ["R-HSA-9679509", "R-HSA-9683686", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9694548", "R-HSA-9692916", "R-HSA-166662", "R-HSA-166663", "R-HSA-9694614", "R-HSA-9694322", "R-HSA-9694635"], "pathways": ["R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9694635:r:Translation of Structural Proteins"], "type": "Homologous_superfamily"}, "IPR036327": {"description": "Bacteriophage T4, Gp8 superfamily", "go_ids": [], "go_terms": [], "name": "Gp8_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036328": {"description": "C-type lysozyme inhibitor superfamily", "go_ids": [], "go_terms": [], "name": "MliC_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036329": {"description": "Aromatic amino acid monoxygenase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Aro-AA_hydroxylase_C_sf", "pathway_ids": ["R-HSA-2160456", "R-HSA-8964208", "R-MMU-209905", "R-DDI-209931", "R-DME-209905", "R-HSA-209905", "R-DME-8964208", "R-BTA-8964208", "R-MMU-8964208", "R-CEL-209905", "R-RNO-8964208", "R-RNO-209905", "R-HSA-209931", "R-DDI-8964208", "R-CEL-8964208", "R-HSA-9031628", "R-DDI-209905", "R-RNO-209931", "R-MMU-209931"], "pathways": ["R-HSA-2160456:r:Phenylketonuria", "R-HSA-8964208:r:Phenylalanine metabolism", "R-MMU-209905:r:Catecholamine biosynthesis", "R-DDI-209931:r:Serotonin and melatonin biosynthesis", "R-DME-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-DME-8964208:r:Phenylalanine metabolism", "R-BTA-8964208:r:Phenylalanine metabolism", "R-MMU-8964208:r:Phenylalanine metabolism", "R-CEL-209905:r:Catecholamine biosynthesis", "R-RNO-8964208:r:Phenylalanine metabolism", "R-RNO-209905:r:Catecholamine biosynthesis", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-DDI-8964208:r:Phenylalanine metabolism", "R-CEL-8964208:r:Phenylalanine metabolism", "R-HSA-9031628:r:NGF-stimulated transcription", "R-DDI-209905:r:Catecholamine biosynthesis", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-209931:r:Serotonin and melatonin biosynthesis"], "type": "Homologous_superfamily"}, "IPR036330": {"description": "Oligosaccharyltransferase subunit ost4p superfamily", "go_ids": [], "go_terms": [], "name": "Ost4p_sf", "pathway_ids": ["R-RNO-9931295", "R-MMU-9931295", "R-RNO-9768727", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9918432", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-9931295"], "pathways": ["R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Homologous_superfamily"}, "IPR036331": {"description": "Chagasin-like superfamily", "go_ids": [], "go_terms": [], "name": "Chagasin-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036332": {"description": "L-A virus major coat protein superfamily", "go_ids": [], "go_terms": [], "name": "Major_coat_LA-virus_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036333": {"description": "RNA synthesis protein NSP10 superfamily, coronavirus", "go_ids": ["GO:0008270", "GO:0019079", "GO:0003723"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0019079:viral genome replication:P", "GO:0003723:RNA binding:F"], "name": "NSP10_sf_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR036334": {"description": "Bubble superfamily", "go_ids": [], "go_terms": [], "name": "Bubble_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036336": {"description": "Transcriptional repressor TraM superfamily", "go_ids": [], "go_terms": [], "name": "Tscrpt_rep_TraM_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036337": {"description": "Matrilin, coiled-coil domain superfamily", "go_ids": [], "go_terms": [], "name": "Matrilin_CC_sf", "pathway_ids": ["R-HSA-381426", "R-HSA-8957275", "R-GGA-381426", "R-MMU-8957275", "R-MMU-381426", "R-HSA-3000178", "R-GGA-8957275"], "pathways": ["R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3000178:r:ECM proteoglycans", "R-GGA-8957275:r:Post-translational protein phosphorylation"], "type": "Homologous_superfamily"}, "IPR036338": {"description": "Activator of Hsp90 ATPase, Aha1", "go_ids": [], "go_terms": [], "name": "Aha1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036339": {"description": "PUB-like domain superfamily", "go_ids": [], "go_terms": [], "name": "PUB-like_dom_sf", "pathway_ids": ["R-HSA-532668", "R-DRE-5357905", "R-MMU-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-RNO-532668", "R-MMU-5357905", "R-HSA-5357786", "R-MMU-532668", "R-DRE-5357786", "R-MMU-5357956", "R-DME-532668", "R-DRE-532668"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "type": "Homologous_superfamily"}, "IPR036340": {"description": "MG296-like superfamily", "go_ids": [], "go_terms": [], "name": "MG296-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036341": {"description": "Her-1 superfamily", "go_ids": [], "go_terms": [], "name": "Her-1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036342": {"description": "Superantigen MAM", "go_ids": [], "go_terms": [], "name": "MAM_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036343": {"description": "Glutamyl-tRNA reductase, N-terminal domain superfamily", "go_ids": ["GO:0033014", "GO:0008883", "GO:0050661"], "go_terms": ["GO:0033014:tetrapyrrole biosynthetic process:P", "GO:0008883:glutamyl-tRNA reductase activity:F", "GO:0050661:NADP binding:F"], "name": "GluRdtase_N_sf", "pathway_ids": ["PWY-5188"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)"], "type": "Homologous_superfamily"}, "IPR036344": {"description": "Fungal immunomodulatory protein FIP-Fve superfamily", "go_ids": [], "go_terms": [], "name": "FIP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036345": {"description": "Exoribonuclease, PH domain 2 superfamily", "go_ids": [], "go_terms": [], "name": "ExoRNase_PH_dom2_sf", "pathway_ids": ["R-BTA-450604", "R-MMU-450385", "R-DRE-450385", "R-HSA-9930044", "R-XTR-6791226", "R-XTR-450385", "R-CEL-450385", "R-BTA-450385", "R-DDI-6791226", "R-MMU-429958", "R-RNO-450513", "R-SPO-9930044", "R-XTR-450513", "R-RNO-9930044", "R-SCE-450385", "R-RNO-450604", "R-DRE-9930044", "R-SCE-429958", "R-HSA-380994", "R-HSA-9836573", "R-SCE-6791226", "R-CEL-429958", "R-RNO-450385", "R-CEL-6791226", "R-HSA-429958", "R-SPO-429958", "R-MMU-9930044", "R-MMU-6791226", "R-BTA-429958", "R-DDI-429958", "R-DRE-450513", "R-XTR-429958", "R-BTA-6791226", "R-BTA-450513", "R-DRE-450604", "R-SCE-450513", "R-DRE-429958", "R-XTR-450604", "R-CEL-450513", "R-BTA-9930044", "R-RNO-6791226", "R-HSA-450385", "R-XTR-9930044", "R-RNO-429958", "R-MMU-450513", "R-HSA-6791226", "R-DDI-450385", "R-MMU-450604", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-DDI-450513", "R-SPO-6791226", "R-DDI-9930044"], "pathways": ["R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-9930044:r:Nuclear RNA decay", "R-XTR-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-9930044:r:Nuclear RNA decay", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DRE-9930044:r:Nuclear RNA decay", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DDI-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-XTR-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DRE-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-XTR-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-9930044:r:Nuclear RNA decay", "R-RNO-6791226:r:Major 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"R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-354192:r:Integrin signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-210991:r:Basigin interactions", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in 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signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-5663220:r:RHO GTPases Activate Formins"], "type": "Homologous_superfamily"}, "IPR036351": {"description": "Large ribosomal subunit protein eL32 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_eL32_sf", "pathway_ids": ["R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553", "R-CFA-1799339", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-RNO-9954716", "R-CFA-72706", "R-DDI-9954714", "R-CFA-9954709", "R-SSC-72706", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", 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"R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-CFA-975956", "R-BTA-975956", "R-BTA-9954709", "R-SSC-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-CFA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CFA-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CFA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036352": {"description": "Sema domain superfamily", "go_ids": [], "go_terms": [], "name": "Semap_dom_sf", "pathway_ids": ["R-HSA-9013405", "R-HSA-8874081", "R-HSA-8875555", "R-DRE-399954", "R-MMU-6811558", "R-MMU-8875791", "R-CEL-416482", "R-RNO-416550", "R-MMU-416572", "R-MMU-8865999", "R-SSC-6811558", "R-HSA-6806942", "R-RNO-399954", "R-MMU-8851805", "R-RNO-6811558", "R-MMU-399954", "R-HSA-399955", "R-HSA-8875513", "R-DRE-416550", "R-HSA-9825892", "R-RNO-8865999", "R-MMU-5673001", "R-RNO-5673001", "R-RNO-6806942", "R-DRE-416572", "R-MMU-399955", "R-HSA-416482", "R-HSA-2219530", "R-SSC-416550", "R-HSA-9696264", "R-HSA-5673001", "R-HSA-6811558", "R-MMU-8875555", "R-RNO-5173214", "R-RNO-8875656", "R-DME-416572", "R-RNO-8851805", "R-HSA-399954", "R-DRE-399956", "R-MMU-5173214", "R-DME-416482", "R-RNO-9696264", "R-MMU-8875513", "R-DME-416700", "R-SSC-6806942", "R-RNO-8875555", "R-MMU-9696264", "R-HSA-1257604", "R-SSC-9734091", "R-MMU-399956", "R-MMU-416700", "R-HSA-8865999", "R-MMU-416550", "R-RNO-8851907", "R-SSC-1257604", "R-SSC-8875513", "R-HSA-416550", "R-HSA-399956", "R-HSA-416572", "R-RNO-1257604", "R-CEL-416700", "R-RNO-9734091", "R-RNO-8874081", "R-RNO-8875513", "R-MMU-8874081", "R-CEL-399955", "R-HSA-416700", "R-HSA-8851907", "R-SSC-8874081", "R-MMU-8852405", "R-HSA-9615017", "R-CEL-399956", "R-HSA-8851805", "R-SSC-8851907", "R-MMU-9734091", "R-HSA-9734091", "R-RNO-399956", "R-HSA-8875791", "R-HSA-8852405", "R-SSC-6807004", "R-HSA-9013508", "R-HSA-9696270", "R-RNO-416700", "R-RNO-8875791", "R-HSA-5083635", "R-SSC-8875555", "R-MMU-1257604", "R-HSA-6807004", "R-CEL-416572", "R-RNO-6807004", "R-SSC-5673001", "R-MMU-6806942", "R-RNO-399955", "R-HSA-5173214", "R-MMU-8851907", "R-MMU-8875656", "R-MMU-416482", "R-SSC-8875791", "R-HSA-9022699", "R-MMU-6807004", "R-SSC-8865999", "R-HSA-8875656", "R-SSC-8851805", "R-DME-5173214", "R-MMU-9696273", "R-MMU-9696270", "R-SSC-8875656", "R-HSA-8875360", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-MMU-6811558:r:PI5P, PP2A and IER3 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"R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-6806942:r:MET Receptor Activation", "R-DRE-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-SSC-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-8875656:r:MET receptor recycling", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-8851805:r:MET activates RAS signaling", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-DME-416482:r:G alpha (12/13) signalling events", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-DME-416700:r:Other semaphorin interactions", "R-SSC-6806942:r:MET Receptor Activation", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-SSC-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-416700:r:Other semaphorin interactions", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-SSC-8875513:r:MET interacts with TNS proteins", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-416700:r:Other semaphorin interactions", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-SSC-8874081:r:MET activates PTK2 signaling", "R-MMU-8852405:r:Signaling by MST1", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-HSA-8851805:r:MET activates RAS signaling", "R-SSC-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-8852405:r:Signaling by MST1", "R-SSC-6807004:r:Negative regulation of MET activity", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-416700:r:Other semaphorin interactions", "R-RNO-8875791:r:MET activates STAT3", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-SSC-8875555:r:MET activates RAP1 and RAC1", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-6807004:r:Negative regulation of MET activity", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-6806942:r:MET Receptor Activation", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-SSC-8875791:r:MET activates STAT3", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-MMU-6807004:r:Negative regulation of MET activity", "R-SSC-8865999:r:MET activates PTPN11", "R-HSA-8875656:r:MET receptor recycling", "R-SSC-8851805:r:MET activates RAS signaling", "R-DME-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SSC-8875656:r:MET receptor recycling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036353": {"description": "XPC-binding domain superfamily", "go_ids": ["GO:0043161", "GO:0006289", "GO:0003684"], "go_terms": ["GO:0043161:proteasome-mediated ubiquitin-dependent protein catabolic process:P", "GO:0006289:nucleotide-excision repair:P", "GO:0003684:damaged DNA binding:F"], "name": "XPC-bd_sf", "pathway_ids": ["R-HSA-532668", "R-DDI-5696395", "R-BTA-5696394", "R-RNO-5696395", "R-BTA-5689877", "R-SPO-5696394", "R-RNO-5696394", "R-SPO-5696395", "R-MMU-5696395", "R-MMU-5689877", "R-RNO-5689877", "R-DDI-5696394", "R-RNO-532668", "R-HSA-5696395", "R-HSA-5696394", "R-MMU-5696394", "R-MMU-532668", "R-BTA-5696395", "R-BTA-532668", "R-HSA-5689877", "R-CEL-8856825"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5689877:r:Josephin domain DUBs", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5689877:r:Josephin domain DUBs", "R-RNO-5689877:r:Josephin domain DUBs", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689877:r:Josephin domain DUBs", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis"], "type": "Homologous_superfamily"}, "IPR036354": {"description": "Proteinase inhibitor I13, potato inhibitor I superfamily", "go_ids": [], "go_terms": [], "name": "Prot_inh_pot1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036356": {"description": "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily", "go_ids": [], 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[], "type": "Homologous_superfamily"}, "IPR036364": {"description": "SEA domain superfamily", "go_ids": [], "go_terms": [], "name": "SEA_dom_sf", "pathway_ids": ["R-HSA-5083632", "R-HSA-6809371", "R-MMU-2024096", "R-HSA-977068", "R-HSA-3560783", "R-HSA-3000178", "R-MMU-913709", "R-HSA-9918485", "R-HSA-3656237", "R-HSA-9927418", "R-RNO-2024096", "R-MMU-975634", "R-HSA-3656253", "R-MMU-3000178", "R-HSA-5083625", "R-HSA-913709", "R-HSA-2024096", "R-MMU-2022928", "R-MMU-977068", "R-HSA-9833110", "R-HSA-2022928", "R-RNO-975634", "R-HSA-5621480", "R-RNO-3000178", "R-HSA-9918481", "R-MMU-5683826", "R-HSA-1442490", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-5083636", "R-HSA-216083", "R-HSA-9913351", "R-HSA-1971475", "R-HSA-3000171", "R-HSA-9694614", "R-HSA-6785807", "R-RNO-5683826", "R-HSA-419037", "R-RNO-9913351", "R-HSA-3560801", "R-HSA-9820960", "R-RNO-1971475", "R-MMU-9913351", "R-HSA-5683826", "R-HSA-4420332", "R-RNO-2022928", "R-MMU-1971475", "R-MMU-1442490", "R-HSA-975634", 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"R-CEL-210991:r:Basigin interactions", "R-SSC-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-6798695:r:Neutrophil degranulation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-CFA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-1442490:r:Collagen degradation", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-GGA-1442490:r:Collagen degradation", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-1442490:r:Collagen degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-1442490:r:Collagen degradation", "R-HSA-9856530:r:High laminar flow shear stress activates 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"R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-1442490:r:Collagen degradation", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Homologous_superfamily"}, "IPR036367": {"description": "Adenovirus DNA-binding, C-terminal domain superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Ad_DBP_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036368": {"description": "Adenovirus DNA-binding, zinc binding domain superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "ADBP_zn-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036369": {"description": "High potential iron-sulphur protein superfamily", "go_ids": ["GO:0019646", "GO:0009055"], "go_terms": ["GO:0019646:aerobic electron transport chain:P", "GO:0009055:electron transfer activity:F"], "name": "HIPIP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036371": {"description": "Thiamin pyrophosphokinase, thiamin-binding domain superfamily", "go_ids": ["GO:0009229"], "go_terms": ["GO:0009229:thiamine diphosphate biosynthetic process:P"], "name": "TPK_B1-bd_sf", "pathway_ids": ["R-MMU-196819", "PWY-6898", "PWY-6908", "PWY-6907", "PWY-7356", "R-HSA-196819", "R-BTA-196819", "R-SPO-196819", "R-SCE-196819", "R-CEL-196819"], "pathways": ["R-MMU-196819:r:Vitamin B1 (thiamin) metabolism", "PWY-6898:t:thiamine diphosphate salvage III", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism", "R-SPO-196819:r:Vitamin B1 (thiamin) metabolism", "R-SCE-196819:r:Vitamin B1 (thiamin) metabolism", "R-CEL-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Homologous_superfamily"}, "IPR036372": {"description": "BEACH domain superfamily", "go_ids": [], "go_terms": [], "name": "BEACH_dom_sf", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-DRE-9013148", "R-DRE-6798695", "R-HSA-5626978", "R-HSA-9013148", "R-HSA-2122947", "R-MMU-6798695", "R-MMU-5626978", "R-HSA-112314", "R-HSA-9609736", "R-HSA-163615"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal 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superfamily", "go_ids": ["GO:0000287"], "go_terms": ["GO:0000287:magnesium ion binding:F"], "name": "RuBisCO_lsu_C_sf", "pathway_ids": ["PWY-5723", "PWY-5532"], "pathways": ["PWY-5723:t:Rubisco shunt", "PWY-5532:t:nucleoside and nucleotide degradation (archaea)"], "type": "Homologous_superfamily"}, "IPR036377": {"description": "Gp120 core superfamily", "go_ids": ["GO:0019031"], "go_terms": ["GO:0019031:viral envelope:C"], "name": "Gp120_core_sf", "pathway_ids": ["R-HSA-162588", "R-HSA-175474", "R-HSA-5621480", "R-HSA-171286", "R-HSA-1462054", "R-HSA-173107"], "pathways": ["R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-171286:r:Synthesis and processing of ENV and VPU", "R-HSA-1462054:r:Alpha-defensins", "R-HSA-173107:r:Binding and entry of HIV virion"], "type": "Homologous_superfamily"}, "IPR036378": {"description": "FAS1 domain superfamily", "go_ids": [], "go_terms": [], "name": "FAS1_dom_sf", "pathway_ids": ["R-MMU-3000497", "R-HSA-3000497", "R-HSA-2160916", "R-MMU-2160916", "R-MMU-2142845", "R-HSA-2142845", "R-HSA-977225"], "pathways": ["R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-HSA-2142845:r:Hyaluronan metabolism", "R-HSA-977225:r:Amyloid fiber formation"], "type": "Homologous_superfamily"}, "IPR036379": {"description": "Alpha-amylase inhibitor superfamily", "go_ids": ["GO:0015066"], "go_terms": ["GO:0015066:alpha-amylase inhibitor activity:F"], "name": "A-amylase_inhib_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036380": {"description": "Isochorismatase-like superfamily", "go_ids": [], "go_terms": [], "name": "Isochorismatase-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036381": {"description": "Replication terminator Tus, domain 1", "go_ids": ["GO:0006274", "GO:0003677", "GO:0005737"], "go_terms": ["GO:0006274:DNA replication termination:P", "GO:0003677:DNA binding:F", "GO:0005737:cytoplasm:C"], "name": "Tus_dom1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036382": {"description": "Guanylin superfamily", "go_ids": ["GO:0030250", "GO:0005576"], "go_terms": ["GO:0030250:guanylate cyclase activator activity:F", "GO:0005576:extracellular region:C"], "name": "Guanylin_sf", "pathway_ids": ["R-MMU-8935690", "R-RNO-8935690", "R-HSA-8935690", "R-SSC-8935690"], "pathways": ["R-MMU-8935690:r:Digestion", "R-RNO-8935690:r:Digestion", "R-HSA-8935690:r:Digestion", "R-SSC-8935690:r:Digestion"], "type": "Homologous_superfamily"}, "IPR036383": {"description": "Thrombospondin type-1 repeat superfamily", "go_ids": [], "go_terms": [], "name": "TSP1_rpt_sf", "pathway_ids": ["R-HSA-186797", "R-HSA-2032785", "R-HSA-6798695", "R-HSA-8939256", "R-MMU-4641263", "R-HSA-8936459", "R-RNO-1474228", "R-DRE-4641263", "R-HSA-418889", "R-HSA-418886", "R-BTA-5173214", "R-MMU-166665", "R-MMU-8957275", "R-HSA-9845621", "R-HSA-1650814", "R-RNO-977606", "R-HSA-114608", "R-HSA-166665", "R-DRE-5173214", "R-HSA-977606", "R-HSA-416700", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-GGA-8957275", "R-CEL-373752", "R-HSA-174577", "R-RNO-373752", "R-GGA-381426", "R-HSA-381426", "R-BTA-1650814", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-BTA-166665", "R-HSA-2404192", "R-MMU-977606", "R-HSA-216083", "R-HSA-3000170", "R-RNO-416700", "R-HSA-5083635", "R-HSA-8951671", "R-HSA-4641263", "R-HSA-9845619", "R-HSA-373752", "R-BTA-4641263", "R-MMU-2404192", "R-MMU-173736", "R-RNO-381426", "R-RNO-5173214", "R-XTR-4641263", "R-HSA-75892", "R-RNO-166665", "R-HSA-5173214", "R-MMU-1650814", "R-HSA-173736", "R-MMU-5173214", "R-MMU-216083", "R-MMU-6798695", "R-HSA-8957275", "R-DME-416700", "R-DME-5173214", "R-MMU-373752", "R-MMU-186797", "R-MMU-416700", "R-CEL-5173214", "R-DME-373752", "R-MMU-114608"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-DRE-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-114608:r:Platelet degranulation", "R-HSA-166665:r:Terminal pathway of complement", "R-DRE-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-CEL-373752:r:Netrin-1 signaling", "R-HSA-174577:r:Activation of C3 and C5", "R-RNO-373752:r:Netrin-1 signaling", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-166665:r:Terminal pathway of complement", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-3000170:r:Syndecan interactions", "R-RNO-416700:r:Other semaphorin interactions", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-373752:r:Netrin-1 signaling", "R-BTA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-166665:r:Terminal pathway of complement", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-173736:r:Alternative complement activation", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DME-416700:r:Other semaphorin interactions", "R-DME-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-373752:r:Netrin-1 signaling", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-416700:r:Other semaphorin interactions", "R-CEL-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-DME-373752:r:Netrin-1 signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036384": {"description": "Replication terminator Tus superfamily", "go_ids": ["GO:0006274", "GO:0003677", "GO:0005737"], "go_terms": ["GO:0006274:DNA replication termination:P", "GO:0003677:DNA binding:F", "GO:0005737:cytoplasm:C"], "name": "Tus_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036385": {"description": "Ribulose bisphosphate carboxylase, small subunit superfamily", "go_ids": [], "go_terms": [], "name": "RuBisCO_ssu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036386": {"description": "HscB, C-terminal domain superfamily", "go_ids": ["GO:0051259"], "go_terms": ["GO:0051259:protein complex oligomerization:P"], "name": "HscB_C_sf", "pathway_ids": ["R-SPO-9865881", "R-HSA-1362409", "R-HSA-9865881", "R-SCE-1362409", "R-HSA-1268020", "R-MMU-6799198", "R-HSA-6799198", "R-MMU-1362409", "R-MMU-1268020", "R-SCE-1268020", "R-SCE-9865881", "R-SPO-1268020", "R-SPO-1362409", "R-MMU-9865881"], "pathways": ["R-SPO-9865881:r:Complex III assembly", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9865881:r:Complex III assembly", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-1268020:r:Mitochondrial protein import", "R-SCE-1268020:r:Mitochondrial protein import", "R-SCE-9865881:r:Complex III assembly", "R-SPO-1268020:r:Mitochondrial protein import", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR036387": {"description": "Neurohypophysial hormone domain superfamily", "go_ids": ["GO:0005185", "GO:0005576"], "go_terms": ["GO:0005185:neurohypophyseal hormone activity:F", "GO:0005576:extracellular region:C"], "name": "Neurhyp_horm_dom_sf", "pathway_ids": ["R-DRE-8856825", "R-MMU-416476", "R-MMU-8856828", "R-HSA-879518", "R-SSC-432040", "R-RNO-8856825", "R-MMU-8856825", "R-RNO-388479", "R-HSA-8856828", "R-SSC-388479", "R-HSA-418555", "R-HSA-416476", "R-SSC-879518", "R-RNO-879518", "R-HSA-388479", "R-HSA-1368108", "R-SSC-416476", "R-MMU-432040", "R-BTA-416476", "R-BTA-388479", "R-MMU-388479", "R-MMU-879518", "R-SSC-8856828", "R-HSA-432040", "R-DRE-388479", "R-HSA-8856825", "R-DRE-879518", "R-SSC-8856825", "R-RNO-8856828", "R-RNO-432040", "R-DRE-416476", "R-HSA-9036092", "R-RNO-416476", "R-DRE-432040", "R-MMU-418555", "R-HSA-5619099"], "pathways": ["R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-879518:r:Organic anion transport by SLCO transporters", "R-SSC-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-388479:r:Vasopressin-like receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-388479:r:Vasopressin-like receptors", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-416476:r:G alpha (q) signalling events", "R-SSC-879518:r:Organic anion transport by SLCO transporters", "R-RNO-879518:r:Organic anion transport by SLCO transporters", "R-HSA-388479:r:Vasopressin-like receptors", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-SSC-416476:r:G alpha (q) signalling events", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-416476:r:G alpha (q) signalling events", "R-BTA-388479:r:Vasopressin-like receptors", "R-MMU-388479:r:Vasopressin-like receptors", "R-MMU-879518:r:Organic anion transport by SLCO transporters", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-388479:r:Vasopressin-like receptors", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-879518:r:Organic anion transport by SLCO transporters", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-416476:r:G alpha (q) signalling events", "R-HSA-9036092:r:Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)", "R-RNO-416476:r:G alpha (q) signalling events", "R-DRE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-5619099:r:Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)"], "type": "Homologous_superfamily"}, "IPR036388": {"description": "Winged helix-like DNA-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "WH-like_DNA-bd_sf", "pathway_ids": ["R-HSA-9013405", "R-HSA-174178", "R-HSA-6807505", "R-HSA-9604323", "R-BTA-975957", "R-CEL-72165", "R-HSA-8951664", "R-DDI-73776", "R-MMU-6804756", "R-DDI-6782210", "R-HSA-69231", "R-DDI-72163", "R-MMU-110314", "R-SPO-5689880", "R-MMU-5689880", "R-DME-198693", "R-DDI-9929491", "R-CEL-9770562", "R-MMU-76061", "R-MMU-5696394", "R-MMU-975110", "R-CEL-5696394", "R-DME-211163", "R-HSA-211733", "R-HSA-9708530", "R-HSA-3270619", "R-DME-9607240", "R-MMU-176409", "R-MMU-9934037", "R-SPO-76066", "R-HSA-5657655", "R-MMU-3134975", "R-DDI-5673001", "R-CEL-2559585", "R-GGA-3134963", "R-RNO-9705462", "R-MMU-1234176", "R-RNO-76061", "R-BTA-69017", "R-SPO-73779", "R-DDI-113418", "R-MMU-72086", "R-MMU-3108214", "R-DRE-8980692", "R-DME-2559586", "R-XTR-9614399", "R-BTA-349425", "R-DDI-382556", "R-RNO-198693", "R-MMU-187577", "R-SSC-936964", "R-CEL-5687128", "R-BTA-3371511", "R-CEL-3371511", "R-HSA-1606322", "R-HSA-9824272", "R-BTA-5676590", "R-DME-2028269", "R-MMU-5693565", "R-RNO-140342", "R-XTR-5693568", "R-DDI-8876198", "R-HSA-73780", "R-CEL-72163", "R-SCE-72689", "R-MMU-9617828", "R-MMU-3371453", "R-SSC-6781823", "R-SCE-73779", "R-DDI-9639288", "R-GGA-975110", "R-HSA-72203", "R-DDI-917937", "R-DDI-69231", "R-RNO-9755511", "R-RNO-75955", "R-DME-6798695", "R-SPO-69017", "R-MMU-9013424", "R-MMU-3371571", "R-HSA-9709603", "R-MMU-176412", "R-MMU-6783310", "R-RNO-5685942", "R-BTA-6803529", "R-MMU-77075", "R-DME-1181150", "R-BTA-9954709", "R-HSA-674695", "R-RNO-9617629", "R-DDI-156827", "R-CEL-9762114", "R-HSA-5358346", "R-CEL-8951664", "R-RNO-6807505", "R-MMU-1660516", "R-BTA-918233", "R-HSA-9932298", "R-HSA-69273", "R-BTA-6798695", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-8951664", "R-BTA-76061", "R-DDI-5675482", "R-MMU-9954716", "R-RNO-68911", "R-CEL-72706", "R-HSA-9013408", "R-SPO-72086", "R-HSA-111459", "R-HSA-69481", "R-DME-9762114", "R-SPO-72706", "R-HSA-9687136", "R-BTA-72086", "R-SCE-975956", "R-DME-9018519", "R-RNO-5693579", "R-BTA-5358346", "R-RNO-5693607", "R-RNO-69473", "R-SPO-5689603", "R-HSA-1660516", "R-HSA-180585", "R-SPO-1236978", "R-HSA-167200", "R-RNO-112382", "R-BTA-168928", "R-MMU-176187", "R-DME-5607764", "R-HSA-9954714", "R-DME-68911", "R-RNO-2559585", "R-SPO-6798695", "R-BTA-382556", "R-CEL-72702", "R-CEL-8939902", "R-HSA-8952158", "R-MMU-72649", "R-HSA-192823", "R-HSA-9035034", "R-HSA-113418", "R-HSA-1834949", "R-SCE-983168", "R-MMU-209931", "R-RNO-174411", "R-SPO-72203", "R-MMU-2028269", "R-HSA-9706019", "R-MMU-5693548", "R-CEL-9614399", "R-SCE-72086", "R-HSA-69601", "R-HSA-983168", "R-MMU-9033241", "R-HSA-9673324", "R-CEL-77075", "R-BTA-5689603", "R-BTA-8856825", "R-SCE-72649", "R-MMU-68949", "R-DRE-3108214", 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"R-HSA-8856825", "R-HSA-75955", "R-CEL-9018519", "R-DME-9020702", "R-DDI-975957", "R-RNO-9833482", "R-RNO-72706", "R-MMU-9013106", "R-CEL-5099900", "R-HSA-6796648", "R-MMU-381676", "R-MMU-72706", "R-HSA-167246", "R-RNO-111458", "R-HSA-5693607", "R-HSA-3371453", "R-DME-3371571", "R-RNO-9772755", "R-HSA-8943724", "R-DDI-9013423", "R-SCE-5668541", "R-BTA-156827", "R-BTA-5687128", "R-SPO-9603798", "R-HSA-5678895", "R-HSA-75102", "R-HSA-1502540", "R-MMU-6807505", "R-CEL-6804758", "R-HSA-9823739", "R-DME-9841251", "R-MMU-4641257", "R-BTA-9770562", "R-HSA-975110", "R-RNO-211163", "R-BTA-1169408", "R-MMU-1660517", "R-MMU-5693571", "R-RNO-75953", "R-RNO-2514859", "R-DDI-8866654", "R-DME-9617629", "R-SCE-6782135", "R-SPO-3232118", "R-SCE-76066", "R-XTR-9018519", "R-HSA-9704646", "R-XTR-9013422", "R-MMU-9755511", "R-MMU-983231", "R-HSA-8953750", "R-DME-9617828", "R-RNO-1912408", "R-HSA-6804758", "R-HSA-112126", "R-HSA-8877330", "R-MMU-2514859", "R-DRE-174430", "R-DME-983231", "R-SCE-5693548", "R-CEL-68911", "R-DME-450728", "R-HSA-176407", "R-BTA-9907900", "R-DDI-69017", "R-MMU-6814122", "R-MMU-5655862", "R-BTA-8948751", "R-MMU-1170546", "R-CEL-198693", "R-RNO-9929491", "R-HSA-9013973", "R-DDI-1660516", "R-HSA-2894862", "R-HSA-1236978", "R-RNO-381676", "R-SCE-9954714", "R-HSA-5632684", "R-SCE-68962", "R-BTA-933541", "R-MMU-140342", "R-CEL-2028269", "R-SPO-6804758", "R-DME-209440", "R-CEL-9764725", "R-CEL-2514859", "R-HSA-9933946", "R-HSA-69202", "R-RNO-6781823", "R-BTA-174411", "R-HSA-9013409", "R-CEL-1181150", "R-RNO-174437", "R-XTR-8856825", "R-BTA-1234176", "R-CEL-72203", "R-RNO-5693565", "R-MMU-69017", "R-RNO-5655862", "R-DRE-111458", "R-XTR-4641262", "R-CEL-3371568", "R-BTA-350562", "R-MMU-112382", "R-DDI-179409", "R-RNO-8863795", "R-CEL-975956", "R-MMU-174414", "R-RNO-6804116", "R-DDI-5213460", "R-MMU-75102", "R-DDI-5673000", "R-BTA-936964", "R-DDI-176407", "R-HSA-210746", "R-RNO-4641258", "R-HSA-9931269", "R-HSA-2408557", "R-CEL-917937", "R-MMU-9615017", "R-HSA-416482", "R-CEL-6782210", "R-RNO-5693571", "R-HSA-9696264", "R-RNO-5693568", "R-MMU-193648", "R-MMU-6804758", "R-HSA-9013026", "R-BTA-73776", "R-SPO-72689", "R-SCE-73776", "R-SCE-3108214", "R-SSC-3134973", "R-DDI-76066", "R-HSA-5610785", "R-MMU-174430", "R-SCE-6798695", "R-DME-73779", "R-HSA-9013106", "R-CEL-983168", "R-HSA-9614399", "R-BTA-8939247", "R-MMU-8939236", "R-GGA-140342", "R-BTA-72706", "R-DME-111458", "R-DDI-5689603", "R-SPO-1799339", "R-SCE-1799339", "R-SCE-176187", "R-HSA-176187", "R-DME-3108214", "R-MMU-202424", "R-HSA-176412", "R-HSA-381038", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-392517", "R-HSA-9841251", "R-DDI-209931", "R-HSA-210745", "R-RNO-76066", "R-HSA-5651801", "R-XTR-8951664", "R-DDI-2514859", "R-MMU-156827", "R-SPO-9033241", "R-RNO-77075", "R-DME-3214847", "R-MMU-8939902", "R-DRE-9013422", "R-BTA-917729", "R-HSA-5693579", "R-SPO-72163", "R-BTA-72203", "R-HSA-8939236", "R-CEL-3371453", "R-HSA-112382", "R-HSA-73779", "R-HSA-422356", "R-BTA-983168", "R-MMU-9607240", "R-CEL-975957", "R-DME-6781823", "R-DRE-8951664", "R-MMU-9639288", "R-MMU-76066", "R-HSA-9927418", "R-DDI-5632684", "R-HSA-975956", "R-MMU-9833482", "R-RNO-392517", "R-HSA-4641257", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9603798", "R-HSA-5656121", "R-MMU-73779", "R-DRE-76061", "R-SPO-75953", "R-DRE-5689901", "R-RNO-975957", "R-HSA-176409", "R-HSA-9821993", "R-DME-3371453", "R-DRE-72695", "R-RNO-76042", "R-MMU-5651801", "R-HSA-9755511", "R-DDI-72086", "R-MMU-674695", "R-DME-5687128", "R-MMU-9018519", "R-RNO-77042", "R-HSA-381676", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-SPO-156827", "R-RNO-5693616", "R-MMU-5696397", "R-HSA-2559586", "R-BTA-8939902", "R-RNO-201688", "R-BTA-9766229", "R-SPO-5651801", "R-HSA-3371511", "R-RNO-68962", "R-DME-156827", "R-DDI-9755511", "R-RNO-9603798", "R-HSA-2559585", "R-CEL-72086", "R-HSA-72086", "R-MMU-201688", "R-MMU-9013973", "R-RNO-72689", "R-DDI-9013149", "R-HSA-1912408", "R-DDI-381676", "R-BTA-3270619", "R-CEL-1538133", "R-HSA-167152", "R-BTA-174430", "R-MMU-5689603", "R-CEL-3214847", "R-HSA-2173796", "R-XTR-72695", "R-SPO-77075", "R-CEL-392517", "R-CEL-9841251", "R-HSA-174411", "R-MMU-9764725", "R-MMU-8939243", "R-BTA-1799339", "R-MMU-176407", "R-HSA-5668541", "R-MMU-9933947", "R-SPO-5696400", "R-HSA-9705462", "R-HSA-9758920", "R-MMU-936440", "R-DME-5693548", "R-MMU-9634638", "R-BTA-9841251", "R-HSA-2892247", "R-DDI-174178", "R-DDI-9954716", "R-HSA-2028269", "R-HSA-9696273", "R-RNO-9013422", "R-BTA-5689880", "R-MMU-9770562", "R-HSA-9010553", "R-RNO-9018519", "R-MMU-5685938", "R-DME-2559585", "R-DME-5696394", "R-MMU-69473", "R-MMU-1538133", "R-SCE-9603798", "R-HSA-69656", "R-SPO-6796648", "R-HSA-450408", "R-HSA-749476", "R-CEL-73776", "R-HSA-111463", "R-HSA-9834899", "R-SCE-5689880", "R-HSA-140342", "R-DDI-6798695", "R-MMU-8866654", "R-DME-350369", "R-DME-9772755", "R-MMU-2173796", "R-HSA-6803529", "R-HSA-452723", "R-MMU-2151201", "R-CEL-674695", "R-HSA-72163", "R-RNO-9764725", "R-DDI-5696394", "R-HSA-3232118", "R-HSA-179409", "R-HSA-68911", "R-DDI-9013418", "R-MMU-1181150", "R-GGA-433819", "R-HSA-201681", "R-DME-202424", "R-DME-187577", "R-DME-72649", "R-RNO-5693548", "R-XTR-72702", "R-SCE-3371568", "R-BTA-4608870", "R-MMU-349425", "R-DME-9770562", "R-HSA-114608", "R-BTA-2871837", "R-BTA-174154", "R-MMU-9627069", "R-RNO-354192", "R-DDI-69601", "R-HSA-912446", "R-HSA-4641262", "R-HSA-9013148", "R-DDI-76042", "R-DDI-5689880", "R-MMU-5696400", "R-DME-176187", "R-HSA-113501", "R-HSA-9696270", "R-HSA-6803207", "R-CEL-9755511", "R-BTA-5696394", "R-MMU-5656169", "R-HSA-72764", "R-BTA-9929356", "R-MMU-3214858", "R-MMU-5676590", "R-BTA-9013422", "R-HSA-167290", "R-CEL-201688", "R-RNO-422356", "R-SPO-6782210", "R-SPO-68962", "R-HSA-3214847", "R-RNO-6814122", "R-HSA-76042", "R-HSA-9761174", "R-MMU-9696273", "R-SPO-8854050", "R-HSA-6798695", "R-MMU-5632684", "R-HSA-2151201", "R-SPO-9907900", "R-HSA-5693616", "R-BTA-5610785", "R-SPO-3371571", "R-MMU-2467813", "R-DDI-9603798", "R-CEL-9013409", "R-BTA-3232118", "R-RNO-3108214", "R-HSA-9764790", "R-HSA-139915", "R-SPO-5696395", "R-DME-174113", "R-DDI-9954714", "R-HSA-75953", "R-MMU-174437", "R-CEL-2559584", "R-MMU-9929356", "R-HSA-77075", "R-BTA-8953750", "R-CEL-9954716", "R-CEL-9954714", "R-SPO-975956", "R-DDI-1483248", "R-RNO-156827", "R-BTA-174084", "R-DME-674695", "R-DDI-73779", "R-DDI-8948751", "R-CEL-2173796", "R-CEL-4086400", "R-DDI-174048", "R-SSC-3232118", "R-SCE-76042", "R-MMU-9708530", "R-DME-6807505", "R-MMU-68689", "R-HSA-3134973", "R-BTA-72649", "R-DME-2871837", "R-XTR-2028269", "R-MMU-6803529", "R-DDI-176408", "R-DDI-6782135", "R-DDI-975956", "R-MMU-8863795", "R-DME-9634638", "R-MMU-933541", "R-XTR-5632684", "R-CEL-5663220", "R-MMU-110312", "R-SPO-110312", "R-MMU-9013148", "R-CEL-72695", "R-BTA-2173796", "R-RNO-114608", "R-HSA-2565942", "R-DRE-6783310", "R-HSA-918233", "R-MMU-198693", "R-SSC-8856825", "R-MMU-5658442", "R-HSA-174084", "R-MMU-4608870", "R-RNO-6803529", "R-BTA-5610780", "R-DME-72695", "R-MMU-72702", "R-RNO-8856825", "R-DDI-3295583", "R-XTR-5663220", "R-HSA-72689", "R-MMU-1169408", "R-BTA-9954714", "R-SPO-3371511", "R-DDI-349425", "R-HSA-69017", "R-BTA-9020702", "R-BTA-975956", "R-HSA-9013406", "R-HSA-174437", "R-HSA-9637628", "R-DDI-174154", "R-HSA-9633012", "R-RNO-917729", "R-HSA-9607240", "R-MMU-9933946", "R-HSA-9013418", "R-MMU-917729", "R-MMU-8941858", "R-RNO-73779", "R-MMU-174154", "R-RNO-5687128", "R-MMU-8939247", "R-MMU-9013409", "R-HSA-5693565", "R-MMU-3134963", "R-MMU-9706019", "R-MMU-69481", "R-BTA-76066", "R-BTA-9018519", "R-DDI-8856825", "R-RNO-9033241", "R-HSA-73776", "R-HSA-5684264", "R-BTA-75815", "R-BTA-77075", "R-RNO-5696397", "R-MMU-5668541", "R-BTA-69601", "R-XTR-9013418", "R-SCE-9033241", "R-CEL-75953", "R-DME-9764725", "R-HSA-5610783", "R-HSA-9614657", "R-HSA-2122947", "R-BTA-68867", "R-HSA-198753", "R-MMU-6791226", "R-BTA-75953", "R-MMU-174113", "R-HSA-174430", "R-HSA-983231", "R-HSA-8851708", "R-RNO-5696394", "R-RNO-72649", "R-HSA-167161", "R-HSA-9933937", "R-HSA-167160", "R-HSA-5696395", "R-CEL-72649", "R-HSA-174048", "R-HSA-9031628", "R-MMU-5687128", "R-DME-72702", "R-HSA-264870", "R-MMU-5663220", "R-MMU-446107", "R-SCE-917937", "R-HSA-5685942", "R-MMU-8852276", "R-SCE-8854050", "R-CEL-3371571"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-8951664:r:Neddylation", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-198693:r:AKT phosphorylates targets in the nucleus", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-211163:r:AKT-mediated inactivation of FOXO1A", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DME-9607240:r:FLT3 Signaling", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-5657655:r:MGMT-mediated DNA damage reversal", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-CEL-2559585:r:Oncogene Induced Senescence", "R-GGA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-XTR-9614399:r:Regulation of localization of FOXO transcription factors", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-RNO-198693:r:AKT phosphorylates targets in the nucleus", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SSC-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-3371511:r:HSF1 activation", "R-CEL-3371511:r:HSF1 activation", "R-HSA-1606322:r:ZBP1(DAI) mediated induction of type I IFNs", "R-HSA-9824272:r:Somitogenesis", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-2028269:r:Signaling by Hippo", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-XTR-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-GGA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-6798695:r:Neutrophil degranulation", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-1181150:r:Signaling by NODAL", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-68911:r:G2 Phase", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SPO-72086:r:mRNA Capping", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-BTA-72086:r:mRNA Capping", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-SPO-5689603:r:UCH proteinases", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-68911:r:G2 Phase", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-209931:r:Serotonin and melatonin biosynthesis", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-2028269:r:Signaling by Hippo", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-CEL-9614399:r:Regulation of localization of FOXO transcription factors", "R-SCE-72086:r:mRNA Capping", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-72649:r:Translation initiation complex formation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-917937:r:Iron uptake and transport", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-CEL-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-DRE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-SPO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-8951664:r:Neddylation", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-77042:r:Formation of editosomes by ADAR proteins", "R-CEL-9035034:r:RHOF GTPase cycle", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-918233:r:TRAF3-dependent IRF activation pathway", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-5693607:r:Processing of DNA double-strand break ends", "R-BTA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-9830364:r:Formation of the nephric duct", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-110478:r:Insulin signaling pathway", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-422356:r:Regulation of insulin secretion", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-3214815:r:HDACs deacetylate histones", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-211163:r:AKT-mediated inactivation of FOXO1A", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-201688:r:WNT mediated activation of DVL", "R-DDI-171007:r:p38MAPK events", "R-HSA-9013420:r:RHOU GTPase cycle", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-209931:r:Serotonin and melatonin biosynthesis", "R-SSC-1606341:r:IRF3 mediated activation of type 1 IFN", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-CEL-418594:r:G alpha (i) signalling events", "R-DME-9614399:r:Regulation of localization of FOXO transcription factors", "R-GGA-2559585:r:Oncogene Induced Senescence", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-SSC-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-XTR-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-GGA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DME-72086:r:mRNA Capping", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-3371511:r:HSF1 activation", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-CEL-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-1538133:r:G0 and Early G1", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-4641258:r:Degradation of DVL", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-354192:r:Integrin signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-GGA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-5620971:r:Pyroptosis", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-SCE-69052:r:Switching of origins to a post-replicative state", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-3371568:r:Attenuation phase", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SSC-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SPO-3371568:r:Attenuation phase", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-9614399:r:Regulation of localization of FOXO transcription factors", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-110312:r:Translesion synthesis by REV1", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-3371568:r:Attenuation phase", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-418594:r:G alpha (i) signalling events", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-BTA-4641258:r:Degradation of DVL", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-114608:r:Platelet degranulation", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-198693:r:AKT phosphorylates targets in the nucleus", "R-DRE-9614399:r:Regulation of localization of FOXO transcription factors", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-RNO-72086:r:mRNA Capping", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-DME-3371511:r:HSF1 activation", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SSC-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DME-201688:r:WNT mediated activation of DVL", "R-DRE-72649:r:Translation initiation complex formation", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DDI-1169092:r:Activation of RAS in B cells", "R-CEL-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-9013408:r:RHOG GTPase cycle", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-XTR-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-MMU-3371568:r:Attenuation phase", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-917937:r:Iron uptake and transport", "R-SCE-418594:r:G alpha (i) signalling events", "R-DRE-211163:r:AKT-mediated inactivation of FOXO1A", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CEL-354192:r:Integrin signaling", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-1538133:r:G0 and Early G1", "R-MMU-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-1538133:r:G0 and Early G1", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-DDI-1632852:r:Macroautophagy", "R-DDI-9907900:r:Proteasome assembly", "R-HSA-156711:r:Polo-like kinase mediated events", "R-XTR-201688:r:WNT mediated activation of DVL", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-72649:r:Translation initiation complex formation", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-SPO-68949:r:Orc1 removal from chromatin", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DDI-354192:r:Integrin signaling", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-BTA-69231:r:Cyclin D associated events in G1", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-DME-69052:r:Switching of origins to a post-replicative state", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-4086400:r:PCP/CE pathway", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-9823730:r:Formation of definitive endoderm", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9796292:r:Formation of axial mesoderm", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-MMU-68911:r:G2 Phase", "R-SCE-68867:r:Assembly of the pre-replicative complex", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-1538133:r:G0 and Early G1", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-193648:r:NRAGE signals death through JNK", "R-DME-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-4641258:r:Degradation of DVL", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-4641258:r:Degradation of DVL", "R-HSA-110312:r:Translesion synthesis by REV1", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-SPO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-RNO-75102:r:C6 deamination of adenosine", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-DRE-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-SSC-8951664:r:Neddylation", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-CEL-3214842:r:HDMs demethylate histones", "R-HSA-354192:r:Integrin signaling", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-193648:r:NRAGE signals death through JNK", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-156711:r:Polo-like kinase mediated events", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DRE-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9830674:r:Formation of the ureteric bud", "R-SCE-9907900:r:Proteasome assembly", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-3371511:r:HSF1 activation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-CEL-6803529:r:FGFR2 alternative splicing", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-XTR-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-77042:r:Formation of editosomes by ADAR proteins", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-DME-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9833482:r:PKR-mediated signaling", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-MMU-3214815:r:HDACs deacetylate histones", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-CFA-114608:r:Platelet degranulation", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-211163:r:AKT-mediated inactivation of FOXO1A", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-69231:r:Cyclin D associated events in G1", "R-DDI-9033241:r:Peroxisomal protein import", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SCE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-4086400:r:PCP/CE pathway", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-SSC-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-8951664:r:Neddylation", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-1236974:r:ER-Phagosome pathway", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-1606341:r:IRF3 mediated activation of type 1 IFN", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-3214815:r:HDACs deacetylate histones", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-1181150:r:Signaling by NODAL", "R-DDI-9706019:r:RHOBTB3 ATPase cycle", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-198693:r:AKT phosphorylates targets in the nucleus", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-GGA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-3214842:r:HDMs demethylate histones", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-DME-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-3214847:r:HATs acetylate histones", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9733709:r:Cardiogenesis", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-CEL-9013420:r:RHOU GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-CEL-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-SSC-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-9013422:r:RHOBTB1 GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-GGA-434136:r:Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1", "R-DRE-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-111458:r:Formation of apoptosome", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-BTA-8951664:r:Neddylation", "R-XTR-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-4641258:r:Degradation of DVL", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-SSC-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-RNO-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9762293:r:Regulation of CDH11 gene transcription", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72649:r:Translation initiation complex formation", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-211163:r:AKT-mediated inactivation of FOXO1A", "R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-156711:r:Polo-like kinase mediated events", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SCE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-3214842:r:HDMs demethylate histones", "R-DME-68962:r:Activation of the pre-replicative complex", "R-CEL-9607240:r:FLT3 Signaling", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-69481:r:G2/M Checkpoints", "R-SPO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-SPO-917937:r:Iron uptake and transport", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-9035034:r:RHOF GTPase cycle", "R-CEL-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-RNO-4086400:r:PCP/CE pathway", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-MMU-392517:r:Rap1 signalling", "R-BTA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-111458:r:Formation of apoptosome", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-BTA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-DME-3371568:r:Attenuation phase", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-XTR-4086400:r:PCP/CE pathway", "R-DDI-4641258:r:Degradation of DVL", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-392517:r:Rap1 signalling", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-CEL-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-RNO-5632684:r:Hedgehog 'on' state", "R-GGA-933541:r:TRAF6 mediated IRF7 activation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SSC-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-418594:r:G alpha (i) signalling events", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-MMU-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-3214847:r:HATs acetylate histones", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-DME-9020702:r:Interleukin-1 signaling", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-RNO-111458:r:Formation of apoptosome", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371571:r:HSF1-dependent transactivation", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-75102:r:C6 deamination of adenosine", "R-HSA-1502540:r:Signaling by Activin", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9823739:r:Formation of the anterior neural plate", "R-DME-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-4641257:r:Degradation of AXIN", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-RNO-211163:r:AKT-mediated inactivation of FOXO1A", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-3232118:r:SUMOylation of transcription factors", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-XTR-9018519:r:Estrogen-dependent gene expression", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-XTR-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DME-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-RNO-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-CEL-68911:r:G2 Phase", "R-DME-450728:r:Inhibition of actin polymerization", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-BTA-933541:r:TRAF6 mediated IRF7 activation", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-CEL-2028269:r:Signaling by Hippo", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-CEL-1181150:r:Signaling by NODAL", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-DRE-111458:r:Formation of apoptosome", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CEL-3371568:r:Attenuation phase", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-RNO-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-75102:r:C6 deamination of adenosine", "R-DDI-5673000:r:RAF activation", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-210746:r:Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-CEL-917937:r:Iron uptake and transport", "R-MMU-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9013026:r:RHOB GTPase cycle", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SSC-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-BTA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-GGA-140342:r:Apoptosis induced DNA fragmentation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DME-111458:r:Formation of apoptosome", "R-DDI-5689603:r:UCH proteinases", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-392517:r:Rap1 signalling", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DDI-209931:r:Serotonin and melatonin biosynthesis", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-XTR-8951664:r:Neddylation", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-9033241:r:Peroxisomal protein import", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-3214847:r:HATs acetylate histones", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DRE-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-422356:r:Regulation of insulin secretion", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9607240:r:FLT3 Signaling", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-8951664:r:Neddylation", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-DDI-5632684:r:Hedgehog 'on' state", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9833482:r:PKR-mediated signaling", "R-RNO-392517:r:Rap1 signalling", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-5689901:r:Metalloprotease DUBs", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-RNO-77042:r:Formation of editosomes by ADAR proteins", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-201688:r:WNT mediated activation of DVL", "R-BTA-9766229:r:Degradation of CDH1", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-3371511:r:HSF1 activation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-MMU-201688:r:WNT mediated activation of DVL", "R-MMU-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-3270619:r:IRF3-mediated induction of type I IFN", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-MMU-5689603:r:UCH proteinases", "R-CEL-3214847:r:HATs acetylate histones", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-392517:r:Rap1 signalling", "R-CEL-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-2028269:r:Signaling by Hippo", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DME-2559585:r:Oncogene Induced Senescence", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-1538133:r:G0 and Early G1", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-9834899:r:Specification of the neural plate border", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-68911:r:G2 Phase", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-1181150:r:Signaling by NODAL", "R-GGA-433819:r:Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-72649:r:Translation initiation complex formation", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-3371568:r:Attenuation phase", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-RNO-354192:r:Integrin signaling", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-912446:r:Meiotic recombination", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-CEL-201688:r:WNT mediated activation of DVL", "R-RNO-422356:r:Regulation of insulin secretion", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9761174:r:Formation of intermediate mesoderm", "R-MMU-9696273:r:RND1 GTPase cycle", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", 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Initiation", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-72649:r:Translation initiation complex formation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-9031628:r:NGF-stimulated transcription", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-SCE-917937:r:Iron uptake and transport", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-3371571:r:HSF1-dependent transactivation"], "type": 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"R-MMU-2470946", "R-HSA-9637628", "R-DDI-174154", "R-RNO-2871837", "R-XTR-5689603", "R-RNO-917729", "R-HSA-9633012", "R-RNO-68949", "R-HSA-9607240", "R-DRE-1169091", "R-HSA-9013418", "R-MMU-8941858", "R-MMU-917729", "R-MMU-174154", "R-RNO-73779", "R-DME-5658442", "R-RNO-382556", "R-RNO-5687128", "R-MMU-8939247", "R-MMU-9013409", "R-DRE-8939236", "R-MMU-3134963", "R-MMU-69481", "R-MMU-9706019", "R-BTA-9018519", "R-DDI-8856825", "R-HSA-73776", "R-HSA-5684264", "R-BTA-75815", "R-BTA-77075", "R-RNO-5696397", "R-MMU-5668541", "R-BTA-69601", "R-XTR-9013418", "R-CEL-75953", "R-HSA-5610783", "R-HSA-9614657", "R-HSA-2122947", "R-DRE-174184", "R-BTA-68867", "R-HSA-198753", "R-SCE-2468052", "R-MMU-6791226", "R-BTA-75953", "R-MMU-174113", "R-HSA-174430", "R-HSA-983231", "R-HSA-8851708", "R-RNO-5689880", "R-RNO-5696394", "R-RNO-72649", "R-HSA-167161", "R-DRE-9755511", "R-HSA-167160", "R-HSA-5696395", "R-CEL-72649", "R-HSA-174048", "R-DME-72702", "R-MMU-5687128", "R-HSA-9031628", "R-DME-5358346", "R-MMU-5663220", "R-SCE-917937", "R-HSA-5685942", "R-MMU-8852276", "R-SCE-8854050", "R-CEL-3371571", "R-MMU-68949", "R-GGA-8951664", "R-GGA-5607764", "R-GGA-2871837", "R-BTA-6781823", "R-XTR-5610780", "R-HSA-2559584", "R-BTA-174184", "R-DME-917937", "R-BTA-6814122", "R-HSA-167172", "R-HSA-5693568", "R-DRE-6781823", "R-BTA-8939236", "R-HSA-5610780", "R-MMU-176408", "R-DME-432626", "R-DME-350480", "R-CEL-9615017", "R-DME-9013422", "R-MMU-5607761", "R-CEL-5689880", "R-HSA-917729", "R-HSA-9754189", "R-HSA-975957", "R-RNO-5696400", "R-HSA-5663220", "R-DME-2173796", "R-GGA-9929356", "R-RNO-195253", "R-MMU-2559585", "R-HSA-6804116", "R-HSA-9013422", "R-MMU-113418", "R-DME-8951664", "R-BTA-76042", "R-SPO-6807505", "R-HSA-9766229", "R-RNO-176187", "R-CEL-187577", "R-MMU-5693616", "R-MMU-9013404", "R-MMU-77042", "R-CEL-9035034", "R-DME-5099900", "R-BTA-9929491", "R-HSA-9709570", "R-RNO-9954716", "R-MMU-918233", "R-DDI-2559582", "R-BTA-1606341", "R-HSA-9610379", "R-MMU-5684264", "R-MMU-9954714", 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"R-RNO-9706019", "R-MMU-5685942", "R-DRE-174084", "R-DRE-450408", "R-CEL-418594", "R-DME-9614399", "R-GGA-2559585", "R-XTR-174178", "R-RNO-5658442", "R-HSA-111448", "R-MMU-9013026", "R-RNO-5610785", "R-SSC-936440", "R-RNO-9617828", "R-GGA-9762114", "R-CEL-76042", "R-DME-68867", "R-XTR-211163", "R-MMU-75953", "R-RNO-5668541", "R-HSA-2559580", "R-SPO-5656169", "R-HSA-73980", "R-HSA-75815", "R-SCE-9841251", "R-RNO-110314", "R-MMU-8948751", "R-HSA-9617828", "R-DME-8948751", "R-GGA-9617828", "R-MMU-8939245", "R-DME-72706", "R-HSA-72695", "R-CEL-110314", "R-HSA-3134963", "R-DME-72086", "R-DME-350411", "R-BTA-1169091", "R-HSA-69052", "R-MMU-3371511", "R-BTA-2500257", "R-DME-5676590", "R-CEL-9617629", "R-SPO-69166", "R-BTA-75955", "R-SPO-176187", "R-HSA-5607761", "R-DDI-174084", "R-HSA-1170546", "R-DRE-917729", "R-RNO-5656121", "R-HSA-5674400", "R-MMU-9932298", "R-RNO-5696395", "R-BTA-72702", "R-GGA-9954716", "R-DME-1538133", "R-HSA-8866654", "R-MMU-4641258", "R-DRE-9766229", "R-DME-112382", "R-HSA-909733", "R-CEL-112382", "R-CEL-6782135", "R-RNO-9954709", "R-BTA-4641257", "R-SPO-8951664", "R-CEL-8948751", "R-MMU-9013418", "R-SPO-73776", "R-MMU-9766229", "R-MMU-354192", "R-RNO-69481", "R-HSA-174154", "R-DDI-187577", "R-GGA-187577", "R-HSA-9833109", "R-RNO-1234176", "R-RNO-9932298", "R-GGA-2559584", "R-BTA-1236978", "R-RNO-4641262", "R-SCE-72706", "R-HSA-5620971", "R-SPO-76061", "R-DRE-4641257", "R-HSA-156827", "R-DRE-983168", "R-DME-2151201", "R-DDI-176409", "R-DDI-9018519", "R-HSA-9762114", "R-HSA-3371568", "R-RNO-9013418", "R-MMU-975956", "R-CEL-8856828", "R-SCE-156827", "R-HSA-76071", "R-SSC-933541", "R-HSA-9770562", "R-SPO-3371568", "R-HSA-167243", "R-RNO-6796648", "R-GGA-9020702", "R-HSA-5099900", "R-DME-8939236", "R-RNO-9614399", "R-RNO-174113", "R-HSA-9634638", "R-DME-351906", "R-HSA-9725371", "R-DME-9954714", "R-CEL-2565942", "R-SPO-110320", "R-HSA-6814122", "R-HSA-9856649", "R-DDI-1799339", "R-DME-975957", "R-XTR-5610785", "R-DME-5689880", "R-SPO-350562", "R-RNO-110312", "R-CEL-8980692", "R-HSA-167238", "R-RNO-674695", "R-BTA-3371568", "R-HSA-8856828", "R-DME-76042", "R-BTA-202424", "R-MMU-5099900", "R-MMU-110320", "R-MMU-2565942", "R-HSA-936964", "R-DDI-1236978", "R-HSA-167287", "R-MMU-5696395", "R-BTA-418594", "R-DME-8939902", "R-CEL-382556", "R-DRE-6798695", "R-RNO-72165", "R-DME-4641262", "R-XTR-5099900", "R-DME-4608870", "R-RNO-6782210", "R-SPO-113418", "R-SPO-2559582", "R-XTR-69017", "R-DDI-6781823", "R-BTA-3371571", "R-DRE-9907900", "R-MMU-3134973", "R-HSA-9735869", "R-SPO-179409", "R-HSA-4641258", "R-HSA-9673768", "R-DRE-5696394", "R-CEL-6781823", "R-RNO-6791226", "R-HSA-9860276", "R-SPO-9770562", "R-BTA-4641258", "R-RNO-6804758", "R-HSA-8939243", "R-HSA-4608870", "R-MMU-9013406", "R-DDI-141430", "R-MMU-6798695", "R-XTR-450408", "R-MMU-1799339", "R-MMU-114608", "R-SPO-72702", "R-MMU-5610780", "R-HSA-1660517", "R-CEL-8863795", "R-HSA-3108214", "R-DRE-9762114", "R-HSA-198693", "R-DRE-9614399", "R-BTA-113418", "R-XTR-2467813", "R-HSA-1221632", "R-HSA-379716", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-69166", "R-HSA-5362768", "R-DDI-9954709", "R-BTA-112382", "R-RNO-8852276", "R-BTA-174178", "R-SCE-3371571", "R-HSA-5685938", "R-XTR-8856828", "R-RNO-72086", "R-MMU-168928", "R-HSA-2500257", "R-HSA-9937080", "R-RNO-110320", "R-HSA-69166", "R-DME-3371511", "R-HSA-9754678", "R-HSA-9824585", "R-BTA-8854050", "R-SSC-168928", "R-HSA-1660514", "R-DME-201688", "R-DRE-72649", "R-XTR-983168", "R-XTR-9755511", "R-SCE-77075", "R-MMU-416482", "R-XTR-1234176", "R-BTA-5607764", "R-DDI-450408", "R-SPO-6782135", "R-CEL-350562", "R-GGA-75815", "R-DDI-1169092", "R-CEL-9634638", "R-HSA-174414", "R-CEL-5632684", "R-HSA-5689880", "R-MMU-9013408", "R-DME-75955", "R-XTR-8939902", "R-HSA-9639288", "R-SCE-6807505", "R-SPO-76042", "R-MMU-9013420", "R-DDI-674695", "R-HSA-76061", "R-GGA-5658442", "R-GGA-5632684", "R-DRE-5668541", "R-HSA-1234176", "R-HSA-9661069", "R-MMU-68867", "R-MMU-72163", "R-DRE-69601", "R-DME-209461", "R-XTR-9929491", "R-HSA-9764725", "R-HSA-72702", "R-SCE-917729", "R-MMU-9860276", "R-DRE-5689603", "R-MMU-3371568", "R-DRE-350562", "R-SPO-110314", "R-CEL-5696395", "R-HSA-5696394", "R-DME-69601", "R-HSA-2644606", "R-MMU-69273", "R-CEL-8856825", "R-DME-69017", "R-DME-983168", "R-RNO-5676590", "R-HSA-2467813", "R-HSA-6781827", "R-HSA-168928", "R-BTA-195253", "R-MMU-8980692", "R-DDI-6791226", "R-RNO-69601", "R-XTR-8939236", "R-HSA-9013423", "R-MMU-917937", "R-SCE-418594", "R-DRE-211163", "R-RNO-5685938", "R-CEL-354192", "R-CEL-75815", "R-HSA-68962", "R-HSA-1538133", "R-MMU-6804116", "R-DRE-75815", "R-DME-8953750", "R-MMU-9762114", "R-GGA-349425", "R-SCE-3232118", "R-MMU-195253", "R-BTA-1538133", "R-HSA-9617629", "R-SCE-72695", "R-MMU-72695", "R-MMU-382556", "R-RNO-113418", "R-DME-209360", "R-DDI-9907900", "R-HSA-156711", "R-XTR-201688", "R-DME-72689", "R-RNO-75815", "R-RNO-72702", "R-MMU-1169091", "R-HSA-72649", "R-DME-8854050", "R-HSA-9909649", "R-MMU-69166", "R-GGA-1169091", "R-RNO-9770562", "R-HSA-5696400", "R-SPO-68949", "R-BTA-6807505", "R-SCE-2514859", "R-RNO-9954714", "R-DRE-8854050", "R-XTR-5676590", "R-DDI-8854050", "R-MMU-8953750", "R-DDI-354192", "R-HSA-1606341", "R-BTA-69231", "R-MMU-72203", "R-HSA-8939256", "R-MMU-5607764", "R-DME-69231", "R-BTA-5668541", "R-GGA-5358346", "R-HSA-5676590", "R-DRE-9954709", "R-DME-4086400", "R-DME-9954716", "R-BTA-72689", "R-HSA-141430", "R-GGA-5687128", "R-HSA-9823730", "R-BTA-72695", "R-MMU-1660514", "R-HSA-9796292", "R-MMU-5693568", "R-RNO-5607761", "R-CEL-9013148", "R-MMU-68911", "R-MMU-76042", "R-RNO-1538133", "R-HSA-176408", "R-GGA-4641257", "R-DDI-193648", "R-DME-8939245", "R-HSA-1799339", "R-CEL-6807505", "R-CEL-4641258", "R-XTR-1236978", "R-RNO-72203", "R-BTA-3371453", "R-XTR-4641258", "R-HSA-110312", "R-CEL-156827", "R-HSA-9013149", "R-HSA-1169091", "R-HSA-8980692", "R-HSA-5658442", "R-BTA-8852276", "R-SPO-68689", "R-XTR-5668541", "R-SCE-674695", "R-HSA-3134975", "R-MMU-174411", "R-GGA-72695", "R-HSA-110314", "R-HSA-8853884", "R-HSA-187577", "R-RNO-3371453", "R-SPO-176408", "R-RNO-75102", "R-DME-382556", "R-HSA-5368598", "R-DRE-6804116", "R-HSA-5358606", "R-DME-8939247", "R-DME-5610780", "R-GGA-4641258", "R-DME-350368", "R-DDI-9770562", "R-HSA-76066", "R-SSC-8951664", "R-HSA-9925561", "R-DME-195253", "R-MMU-69601", "R-SCE-975957", "R-DDI-76061", "R-XTR-4641257", "R-MMU-8854050", "R-DME-5607761", "R-HSA-5656169", "R-HSA-5607764", "R-HSA-354192", "R-SCE-6796648", "R-DRE-5687128", "R-HSA-193648", "R-SPO-3108214", "R-MMU-156711", "R-RNO-5358565", "R-SCE-113418", "R-RNO-6782135", "R-HSA-9933939", "R-DME-538864", "R-GGA-174184", "R-SCE-9907900", "R-HSA-9830674", "R-CEL-68949", "R-HSA-5687128", "R-XTR-195253", "R-HSA-5358565", "R-DDI-72706", "R-SCE-3371511", "R-HSA-110320", "R-CEL-6803529", "R-XTR-1169091"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-XTR-69481:r:G2/M Checkpoints", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-8951664:r:Neddylation", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-XTR-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-198693:r:AKT phosphorylates targets in the nucleus", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-68949:r:Orc1 removal from chromatin", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-XTR-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-211163:r:AKT-mediated inactivation of FOXO1A", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DME-9607240:r:FLT3 Signaling", "R-XTR-4608870:r:Asymmetric localization of PCP proteins", "R-DME-4641257:r:Degradation of AXIN", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-CEL-2559585:r:Oncogene Induced Senescence", "R-GGA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-GGA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DRE-8980692:r:RHOA GTPase cycle", "R-XTR-9614399:r:Regulation of localization of FOXO transcription factors", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-RNO-198693:r:AKT phosphorylates targets in the nucleus", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SSC-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-3371511:r:HSF1 activation", "R-CEL-3371511:r:HSF1 activation", "R-HSA-1606322:r:ZBP1(DAI) mediated induction of type I IFNs", "R-HSA-9824272:r:Somitogenesis", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-2028269:r:Signaling by Hippo", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DRE-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-GGA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-GGA-5689880:r:Ub-specific processing proteases", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-DME-1181150:r:Signaling by NODAL", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-BTA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-RNO-9020702:r:Interleukin-1 signaling", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-918233:r:TRAF3-dependent IRF activation pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-XTR-8948751:r:Regulation of PTEN stability and activity", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-GGA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-68911:r:G2 Phase", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-5689603:r:UCH proteinases", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SPO-72086:r:mRNA Capping", "R-XTR-5689880:r:Ub-specific processing proteases", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-BTA-72086:r:mRNA Capping", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-5689603:r:UCH proteinases", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-68911:r:G2 Phase", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-XTR-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-8952158:r:RUNX3 regulates BCL2L11 (BIM) transcription", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-GGA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-DME-216167:r:Nuclear CI is degraded", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-209931:r:Serotonin and melatonin biosynthesis", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-9907900:r:Proteasome assembly", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2028269:r:Signaling by Hippo", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-CEL-9614399:r:Regulation of localization of FOXO transcription factors", "R-SCE-72086:r:mRNA Capping", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-72649:r:Translation initiation complex formation", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-XTR-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-GGA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-CEL-4641257:r:Degradation of AXIN", "R-HSA-77042:r:Formation of editosomes by ADAR proteins", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-DME-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9833482:r:PKR-mediated signaling", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-CFA-114608:r:Platelet degranulation", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-211163:r:AKT-mediated inactivation of FOXO1A", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DRE-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-CEL-69231:r:Cyclin D associated events in G1", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-4086400:r:PCP/CE pathway", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-GGA-72649:r:Translation initiation complex formation", "R-SSC-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-8951664:r:Neddylation", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1606341:r:IRF3 mediated activation of type 1 IFN", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DRE-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-1181150:r:Signaling by NODAL", "R-DDI-9706019:r:RHOBTB3 ATPase cycle", "R-GGA-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-9907900:r:Proteasome assembly", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-198693:r:AKT phosphorylates targets in the nucleus", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-GGA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-GGA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-DME-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-3214847:r:HATs acetylate histones", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-CEL-9013420:r:RHOU GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DRE-5632684:r:Hedgehog 'on' state", "R-CEL-9013424:r:RHOV GTPase cycle", "R-GGA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DRE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-SSC-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-GGA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-9013422:r:RHOBTB1 GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-GGA-434136:r:Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1", "R-DRE-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-BTA-8951664:r:Neddylation", "R-XTR-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-SSC-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-DRE-69481:r:G2/M Checkpoints", "R-GGA-202424:r:Downstream TCR signaling", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9762293:r:Regulation of CDH11 gene transcription", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72649:r:Translation initiation complex formation", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SPO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-CEL-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-9696270:r:RND2 GTPase cycle", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-211163:r:AKT-mediated inactivation of FOXO1A", "R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-156711:r:Polo-like kinase mediated events", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SCE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-9607240:r:FLT3 Signaling", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-69481:r:G2/M Checkpoints", "R-SPO-917937:r:Iron uptake and transport", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-9766229:r:Degradation of CDH1", "R-MMU-9035034:r:RHOF GTPase cycle", "R-CEL-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-RNO-4086400:r:PCP/CE pathway", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-MMU-392517:r:Rap1 signalling", "R-BTA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-BTA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-DME-3371568:r:Attenuation phase", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-XTR-4086400:r:PCP/CE pathway", "R-DDI-4641258:r:Degradation of DVL", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-HSA-392517:r:Rap1 signalling", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-CEL-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-9614399:r:Regulation of localization of FOXO transcription factors", "R-RNO-5632684:r:Hedgehog 'on' state", "R-GGA-933541:r:TRAF6 mediated IRF7 activation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-3270619:r:IRF3-mediated induction of type I IFN", "R-DRE-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-418594:r:G alpha (i) signalling events", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-418594:r:G alpha (i) signalling events", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9907900:r:Proteasome assembly", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SPO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-XTR-68949:r:Orc1 removal from chromatin", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-GGA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-9020702:r:Interleukin-1 signaling", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-9013106:r:RHOC GTPase cycle", "R-XTR-9766229:r:Degradation of CDH1", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371571:r:HSF1-dependent transactivation", "R-XTR-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-XTR-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-75102:r:C6 deamination of adenosine", "R-HSA-1502540:r:Signaling by Activin", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-4641257:r:Degradation of AXIN", "R-DME-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-RNO-211163:r:AKT-mediated inactivation of FOXO1A", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-3232118:r:SUMOylation of transcription factors", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-XTR-9018519:r:Estrogen-dependent gene expression", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-XTR-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DME-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-RNO-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-5689603:r:UCH proteinases", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-GGA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-68911:r:G2 Phase", "R-DME-450728:r:Inhibition of actin polymerization", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-9907900:r:Proteasome assembly", "R-DRE-68949:r:Orc1 removal from chromatin", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-198693:r:AKT phosphorylates targets in the nucleus", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-5632684:r:Hedgehog 'on' state", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-BTA-933541:r:TRAF6 mediated IRF7 activation", "R-XTR-5358346:r:Hedgehog ligand biogenesis", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-CEL-2028269:r:Signaling by Hippo", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-GGA-5689603:r:UCH proteinases", "R-CEL-1181150:r:Signaling by NODAL", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-CEL-3371568:r:Attenuation phase", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-RNO-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-MMU-75102:r:C6 deamination of adenosine", "R-DME-2467813:r:Separation of Sister Chromatids", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-CEL-917937:r:Iron uptake and transport", "R-MMU-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-XTR-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9013026:r:RHOB GTPase cycle", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SSC-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-DRE-8939902:r:Regulation of RUNX2 expression and activity", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-9907900:r:Proteasome assembly", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9614399:r:Regulation of localization of FOXO transcription factors", "R-BTA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-4641257:r:Degradation of AXIN", "R-GGA-140342:r:Apoptosis induced DNA fragmentation", "R-DME-9907900:r:Proteasome assembly", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-5689603:r:UCH proteinases", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DRE-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-392517:r:Rap1 signalling", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DDI-209931:r:Serotonin and melatonin biosynthesis", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-XTR-8951664:r:Neddylation", "R-XTR-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-XTR-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-9932298:r:Degradation of CRY and PER proteins", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-XTR-9932298:r:Degradation of CRY and PER proteins", "R-DRE-9013422:r:RHOBTB1 GTPase cycle", "R-XTR-382556:r:ABC-family proteins mediated transport", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-422356:r:Regulation of insulin secretion", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-9607240:r:FLT3 Signaling", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-8951664:r:Neddylation", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-DDI-5632684:r:Hedgehog 'on' state", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9833482:r:PKR-mediated signaling", "R-RNO-392517:r:Rap1 signalling", "R-XTR-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-XTR-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-72086:r:mRNA Capping", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-RNO-77042:r:Formation of editosomes by ADAR proteins", "R-GGA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-201688:r:WNT mediated activation of DVL", "R-BTA-9766229:r:Degradation of CDH1", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-3371511:r:HSF1 activation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-MMU-201688:r:WNT mediated activation of DVL", "R-MMU-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-3270619:r:IRF3-mediated induction of type I IFN", "R-CEL-1538133:r:G0 and Early G1", "R-DRE-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-MMU-5689603:r:UCH proteinases", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-392517:r:Rap1 signalling", "R-CEL-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-432395:r:Degradation of TIM", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2028269:r:Signaling by Hippo", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-4641258:r:Degradation of DVL", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DME-2559585:r:Oncogene Induced Senescence", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-XTR-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-5689880:r:Ub-specific processing proteases", "R-BTA-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-432524:r:Degradation of PER", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-68911:r:G2 Phase", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-1181150:r:Signaling by NODAL", "R-GGA-433819:r:Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-GGA-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-72649:r:Translation initiation complex formation", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-3371568:r:Attenuation phase", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-114608:r:Platelet degranulation", "R-GGA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-354192:r:Integrin signaling", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-912446:r:Meiotic recombination", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-CEL-201688:r:WNT mediated activation of DVL", "R-RNO-422356:r:Regulation of insulin secretion", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-9761174:r:Formation of intermediate mesoderm", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9696273:r:RND1 GTPase cycle", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-9907900:r:Proteasome assembly", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-CEL-9013409:r:RHOJ GTPase cycle", "R-BTA-3232118:r:SUMOylation of transcription factors", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-GGA-382556:r:ABC-family proteins mediated transport", "R-GGA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-4086400:r:PCP/CE pathway", "R-XTR-6798695:r:Neutrophil degranulation", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-3232118:r:SUMOylation of transcription factors", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-68867:r:Assembly of the pre-replicative complex", "R-XTR-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-BTA-72649:r:Translation initiation complex formation", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-XTR-2028269:r:Signaling by Hippo", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-XTR-5632684:r:Hedgehog 'on' state", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-GGA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-114608:r:Platelet degranulation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-198693:r:AKT phosphorylates targets in the nucleus", "R-GGA-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-5689603:r:UCH proteinases", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-3371511:r:HSF1 activation", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-DRE-68867:r:Assembly of the pre-replicative complex", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-XTR-5689603:r:UCH proteinases", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9607240:r:FLT3 Signaling", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-DRE-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-69481:r:G2/M Checkpoints", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-XTR-9013418:r:RHOBTB2 GTPase cycle", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-DRE-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-198753:r:ERK/MAPK targets", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-72649:r:Translation initiation complex formation", "R-HSA-167161:r:HIV Transcription Initiation", "R-DRE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-72649:r:Translation initiation complex formation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9031628:r:NGF-stimulated transcription", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-SCE-917937:r:Iron uptake and transport", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-GGA-8951664:r:Neddylation", "R-GGA-5607764:r:CLEC7A (Dectin-1) signaling", "R-GGA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-XTR-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-917937:r:Iron uptake and transport", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-432626:r:Circadian Clock pathway", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-CEL-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-8951664:r:Neddylation", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-77042:r:Formation of editosomes by ADAR proteins", "R-CEL-9035034:r:RHOF GTPase cycle", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-918233:r:TRAF3-dependent IRF activation pathway", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DRE-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-110478:r:Insulin signaling pathway", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-9907900:r:Proteasome assembly", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-422356:r:Regulation of insulin secretion", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-211163:r:AKT-mediated inactivation of FOXO1A", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-201688:r:WNT mediated activation of DVL", "R-DDI-171007:r:p38MAPK events", "R-HSA-9013420:r:RHOU GTPase cycle", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-209931:r:Serotonin and melatonin biosynthesis", "R-SSC-1606341:r:IRF3 mediated activation of type 1 IFN", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-418594:r:G alpha (i) signalling events", "R-DME-9614399:r:Regulation of localization of FOXO transcription factors", "R-GGA-2559585:r:Oncogene Induced Senescence", "R-XTR-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-GGA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-XTR-211163:r:AKT-mediated inactivation of FOXO1A", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-GGA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DME-72086:r:mRNA Capping", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-MMU-3371511:r:HSF1 activation", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-CEL-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-1538133:r:G0 and Early G1", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-GGA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-GGA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-5620971:r:Pyroptosis", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DRE-4641257:r:Degradation of AXIN", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-3371568:r:Attenuation phase", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SSC-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SPO-3371568:r:Attenuation phase", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-9020702:r:Interleukin-1 signaling", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-9614399:r:Regulation of localization of FOXO transcription factors", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-110312:r:Translesion synthesis by REV1", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-3371568:r:Attenuation phase", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-418594:r:G alpha (i) signalling events", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-XTR-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-3371571:r:HSF1-dependent transactivation", 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destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-GGA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-SPO-429947:r:Deadenylation of mRNA", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-6782135:r:Dual incision in TC-NER", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-6782135:r:Dual incision in TC-NER", "R-RNO-203927:r:MicroRNA (miRNA) biogenesis", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-110312:r:Translesion synthesis by REV1", "R-CEL-5656169:r:Termination of translesion DNA synthesis", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-RNO-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-GGA-429947:r:Deadenylation of mRNA", "R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-69091:r:Polymerase switching", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69091:r:Polymerase switching", "R-MMU-68952:r:DNA replication initiation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-69091:r:Polymerase switching", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-69091:r:Polymerase switching", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR036398": {"description": "Alpha carbonic anhydrase domain superfamily", "go_ids": [], "go_terms": [], "name": "CA_dom_sf", "pathway_ids": ["PWY-5743", "PWY-5789", "PWY-7115", "PWY-6142", "PWY-7117", "PWY-241", "PWY-5744", "R-HSA-9925563", "R-HSA-449836", "R-GGA-1475029", "R-MMU-1237044", "R-RNO-1237044", "R-HSA-1247673", "R-RNO-1247673", "R-BTA-1475029", "R-HSA-1234158", "R-RNO-9851151", "R-MMU-1247673", "R-GGA-1247673", "R-HSA-8950505", "R-HSA-1237044", "R-DRE-1247673", "R-BTA-1247673", "R-GGA-1237044", "R-MMU-449836", "R-HSA-1475029", "R-MMU-1475029", "R-HSA-9851151", "R-CEL-1237044", "R-DRE-1237044", "R-MMU-9851151", "R-CEL-1475029", "R-DRE-1475029", "R-BTA-1237044", "R-CEL-1247673", "R-RNO-449836", "R-RNO-1475029"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-241:t:C4 photosynthetic carbon assimilation cycle, NADP-ME type", "PWY-5744:t:glyoxylate assimilation", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-449836:r:Other interleukin signaling", "R-GGA-1475029:r:Reversible hydration of carbon dioxide", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-1475029:r:Reversible hydration of carbon dioxide", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-MMU-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-GGA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DRE-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-BTA-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-GGA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-1475029:r:Reversible hydration of carbon dioxide", "R-MMU-1475029:r:Reversible hydration of carbon dioxide", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-CEL-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DRE-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-CEL-1475029:r:Reversible hydration of carbon dioxide", "R-DRE-1475029:r:Reversible hydration of carbon dioxide", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-CEL-1247673:r:Erythrocytes take up oxygen and release carbon dioxide", "R-RNO-449836:r:Other interleukin signaling", "R-RNO-1475029:r:Reversible hydration of carbon dioxide"], "type": "Homologous_superfamily"}, "IPR036399": {"description": "Pesticidal crystal protein, central domain superfamily", "go_ids": ["GO:0005102"], "go_terms": ["GO:0005102:signaling receptor binding:F"], "name": "Pest_cryst_cen_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036400": {"description": "Cytochrome b5-like heme/steroid binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Cyt_B5-like_heme/steroid_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-1989781", "R-HSA-9013405", "R-RNO-1237044", "R-DRE-2046105", "R-MMU-9013408", "R-RNO-2046106", "R-HSA-5693565", "R-MMU-9013404", "R-HSA-2046105", "R-SCE-196836", "R-HSA-203615", "R-BTA-9609523", "R-MMU-69473", "R-CEL-2046106", "R-HSA-5693607", "R-BTA-196836", "R-MMU-9707616", "R-HSA-196836", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-9013408", "R-HSA-9609523", "R-DME-196836", "R-SSC-196836", "R-HSA-69473", "R-GGA-9609523", "R-SSC-9609523", "R-BTA-2046106", "R-DME-1614517", "R-GGA-6798695", "R-RNO-203615", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-211945", "R-HSA-8980692", "R-RNO-1614517", "R-MMU-6798695", "R-MMU-3108214", "R-HSA-2046106", "R-MMU-5693571", "R-RNO-6798695", "R-MMU-211945", "R-SCE-75105", "R-SPO-6798695", "R-RNO-2046105", "R-SSC-6798695", "R-HSA-3108214", "R-HSA-211945", "R-DRE-2046106", "R-HSA-1614517", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-196836", "R-MMU-203615", "R-RNO-9609523", "R-HSA-1237044", "R-MMU-5693565", "R-HSA-9013423", "R-CEL-2046105", "R-XTR-1237044", "R-DME-9609523", "R-MMU-9609523", "R-RNO-9707616", "R-MMU-1614517", "R-MMU-5693607", "R-MMU-1237044", "R-MMU-196836", "R-MMU-2046106", "R-SPO-75105", "R-HSA-9707616", "R-HSA-983168", "R-HSA-1660661", "R-RNO-9013423", "R-HSA-5693571", "R-SPO-9707616", "R-GGA-196836", "R-SPO-9609523", "R-MMU-983168", "R-RNO-1660661", "R-SCE-9609523", "R-SPO-196836", "R-BTA-1237044", "R-MMU-2046105", "R-BTA-2046105", "R-MMU-1660661"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DRE-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-2046105:r:Linoleic acid (LA) metabolism", "R-SCE-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-203615:r:eNOS activation", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-CEL-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-9707616:r:Heme signaling", "R-HSA-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-196836:r:Vitamin C (ascorbate) metabolism", "R-SSC-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-GGA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-1614517:r:Sulfide oxidation to sulfate", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-203615:r:eNOS activation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-1614517:r:Sulfide oxidation to sulfate", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-DRE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-1614517:r:Sulfide oxidation to sulfate", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-203615:r:eNOS activation", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-2046105:r:Linoleic acid (LA) metabolism", "R-XTR-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9707616:r:Heme signaling", "R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-196836:r:Vitamin C (ascorbate) metabolism", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9707616:r:Heme signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SPO-9707616:r:Heme signaling", "R-GGA-196836:r:Vitamin C (ascorbate) metabolism", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-196836:r:Vitamin C (ascorbate) metabolism", "R-BTA-1237044:r:Erythrocytes take up carbon dioxide and release oxygen", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-BTA-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Homologous_superfamily"}, "IPR036401": {"description": "Small ribosomal subunit protein eS17 superfamily", "go_ids": ["GO:0006412", "GO:0003735", "GO:0005840"], "go_terms": ["GO:0006412:translation:P", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C"], "name": "Ribosomal_eS17_sf", "pathway_ids": ["R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-HSA-9754678", "R-HSA-72649", "R-MMU-156827", "R-SSC-72649", "R-GGA-975957", "R-SCE-72649", "R-HSA-975957", "R-DME-9954714", "R-DDI-72706", "R-GGA-1799339", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-HSA-72695", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-CEL-72706", "R-GGA-72706", "R-CEL-9954716", "R-CEL-9954714", "R-SCE-72702", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-SCE-975956", "R-CEL-1799339", "R-DDI-72695", "R-SSC-9954714", "R-HSA-72706", "R-GGA-9954716", "R-HSA-72702", "R-HSA-9735869", "R-CEL-156827", "R-RNO-72649", "R-RNO-6791226", "R-SSC-1799339", "R-GGA-72649", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-SSC-72689", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-GGA-72695", "R-CEL-72689", "R-GGA-72702", "R-SPO-72689", "R-GGA-975956", "R-DDI-72702", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DDI-72689", "R-MMU-1799339", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-DME-72649", "R-CEL-72695", "R-HSA-156827", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-SSC-72695", "R-SSC-9954716", "R-SSC-156827", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-GGA-9954714", "R-DDI-9954716", "R-SSC-72702", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-SCE-156827", "R-DME-72695", "R-DME-975956", "R-MMU-72702", "R-DME-975957", "R-SPO-72649", "R-SPO-72695", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702"], "pathways": ["R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-72649:r:Translation initiation complex formation", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", 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"R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) 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["GO:0006779:porphyrin-containing compound biosynthetic process:P", "GO:0004109:coproporphyrinogen oxidase activity:F"], "name": "Coprogen_oxidase_aer_sf", "pathway_ids": ["PWY-7159", "R-DDI-189451", "R-RNO-189451", "R-DME-189451", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)", "R-DDI-189451:r:Heme biosynthesis", "R-RNO-189451:r:Heme biosynthesis", "R-DME-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Homologous_superfamily"}, "IPR036407": {"description": "DM DNA-binding domain superfamily", "go_ids": ["GO:0006355", "GO:0043565"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0043565:sequence-specific DNA binding:F"], "name": "DM_DNA-bd_sf", "pathway_ids": ["R-HSA-9690406"], "pathways": ["R-HSA-9690406:r:Transcriptional regulation of testis differentiation"], "type": "Homologous_superfamily"}, "IPR036408": {"description": "Photosystem I PsaA/PsaB superfamily", "go_ids": [], "go_terms": [], "name": "PSI_PsaA/B_sf", "pathway_ids": ["PWY-101", "PWY-8270"], "pathways": ["PWY-101:t:photosynthesis light reactions", "PWY-8270:t:cyclic electron flow"], "type": "Homologous_superfamily"}, "IPR036409": {"description": "Class II aldolase/adducin N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Aldolase_II/adducin_N_sf", "pathway_ids": ["R-HSA-9013405", "R-MMU-9035034", "R-HSA-381038", "R-XTR-9627069", "R-DME-9627069", "R-MMU-5223345", "R-RNO-9035034", "R-DRE-111458", "R-XTR-111458", "R-HSA-111458", "R-MMU-111458", "R-RNO-5223345", "R-DRE-9627069", "R-CEL-9035034", "R-GGA-9627069", "R-BTA-9627069", "R-HSA-1237112", "R-DME-5223345", "R-DME-9035034", "R-CEL-5223345", "R-MMU-9627069", "R-DME-111458", "R-HSA-9035034", "R-DME-264870", "R-MMU-264870", 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"R-HSA-73614:r:Pyrimidine salvage", "R-GGA-5578775:r:Ion homeostasis", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-PFA-446205:r:Synthesis of GDP-mannose", "R-HSA-73621:r:Pyrimidine catabolism", "R-SCE-5578775:r:Ion homeostasis", "R-RNO-9018682:r:Biosynthesis of maresins", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-SCE-1237112:r:Methionine salvage pathway", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-GGA-73621:r:Pyrimidine catabolism", "R-SCE-1483191:r:Synthesis of PC", "R-CEL-446205:r:Synthesis of GDP-mannose", "R-SCE-446205:r:Synthesis of GDP-mannose", "R-SCE-73614:r:Pyrimidine salvage", "R-RNO-1483206:r:Glycerophospholipid biosynthesis", "R-PFA-936837:r:Ion transport by P-type ATPases", "R-SPO-1483191:r:Synthesis of PC", "R-SSC-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-RNO-2161541:r:Abacavir metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-2161541:r:Abacavir metabolism", "R-HSA-2161541:r:Abacavir metabolism", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-DRE-4085001:r:Sialic acid metabolism", "R-XTR-9755088:r:Ribavirin ADME", "R-BTA-977347:r:Serine metabolism", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-MMU-4085001:r:Sialic acid metabolism", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-SPO-5578775:r:Ion homeostasis", "R-CEL-1237112:r:Methionine salvage 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"R-MMU-6803544:r:Ion influx/efflux at host-pathogen interface", "R-MMU-1237112:r:Methionine salvage pathway", "R-HSA-4085001:r:Sialic acid metabolism", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-SCE-418359:r:Reduction of cytosolic Ca++ levels", "R-MTU-868688:r:Trehalose biosynthesis", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-GGA-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-977347:r:Serine metabolism", "R-RNO-977347:r:Serine metabolism", "R-MMU-1483226:r:Synthesis of PI", "R-RNO-71737:r:Pyrophosphate hydrolysis", "R-MMU-5578775:r:Ion homeostasis", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-SSC-5578775:r:Ion homeostasis", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-977347:r:Serine metabolism", "R-DME-73614:r:Pyrimidine salvage", "R-DRE-1237112:r:Methionine salvage pathway", "R-DRE-71737:r:Pyrophosphate hydrolysis", "R-XTR-74259:r:Purine catabolism", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-4085001:r:Sialic acid metabolism", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SPO-1483213:r:Synthesis of PE", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-73621:r:Pyrimidine catabolism", "R-DDI-936837:r:Ion transport by P-type ATPases", "R-DDI-74259:r:Purine catabolism", "R-GGA-936837:r:Ion transport by P-type ATPases", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-RNO-74259:r:Purine catabolism", "R-SPO-73614:r:Pyrimidine salvage", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-446205:r:Synthesis of GDP-mannose", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-CFA-936837:r:Ion transport by P-type ATPases", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-9755088:r:Ribavirin ADME", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CFA-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-9018682:r:Biosynthesis of maresins", "R-CEL-73621:r:Pyrimidine catabolism", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-DDI-9755088:r:Ribavirin ADME", "R-MMU-977347:r:Serine metabolism", "R-DME-977347:r:Serine metabolism", "R-RNO-9755088:r:Ribavirin ADME", "R-DDI-446205:r:Synthesis of GDP-mannose", "R-RNO-5578775:r:Ion homeostasis", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SPO-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-BTA-446205:r:Synthesis of GDP-mannose", "R-BTA-4085001:r:Sialic acid metabolism", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-9033241:r:Peroxisomal protein import", "R-XTR-1237112:r:Methionine salvage pathway", "R-DRE-4419969:r:Depolymerization of the Nuclear Lamina", "R-DDI-1237112:r:Methionine salvage pathway", "R-HSA-1483191:r:Synthesis of PC", "R-CEL-5578775:r:Ion homeostasis", "R-MMU-71737:r:Pyrophosphate hydrolysis", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-PFA-6798695:r:Neutrophil degranulation", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-2142670:r:Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-74259:r:Purine catabolism", "R-SSC-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-9018682:r:Biosynthesis of maresins", "R-BTA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Homologous_superfamily"}, "IPR036413": {"description": "YaeB-like superfamily", "go_ids": [], "go_terms": [], "name": "YaeB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036414": {"description": "YaeB, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "YaeB_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036415": {"description": "Lamin tail domain superfamily", "go_ids": [], "go_terms": [], "name": "Lamin_tail_dom_sf", "pathway_ids": ["R-HSA-9013405", "R-RNO-2995383", "R-HSA-6802952", "R-RNO-352238", "R-RNO-9035034", "R-CEL-4419969", "R-HSA-8862803", "R-RNO-2559584", "R-HSA-1221632", "R-MMU-2559584", "R-DME-352238", "R-CEL-9035034", "R-SSC-4419969", "R-DME-9035034", "R-MMU-2980766", "R-HSA-9035034", "R-CEL-2559584", "R-HSA-352238", "R-HSA-2559584", "R-SSC-2995383", "R-SSC-2980766", "R-MMU-2995383", "R-RNO-2980766", "R-DME-4419969", "R-SSC-352238", "R-MMU-9035034", "R-HSA-381038", "R-HSA-8950505", "R-HSA-2995383", "R-MMU-352238", "R-HSA-4419969", "R-HSA-2980766", "R-MMU-4419969", "R-RNO-4419969"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-352238:r:Breakdown of the nuclear lamina", "R-RNO-9035034:r:RHOF GTPase cycle", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-DME-352238:r:Breakdown of the nuclear lamina", "R-CEL-9035034:r:RHOF GTPase cycle", "R-SSC-4419969:r:Depolymerization of the Nuclear Lamina", "R-DME-9035034:r:RHOF GTPase cycle", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-HSA-9035034:r:RHOF GTPase cycle", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-352238:r:Breakdown of the nuclear lamina", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-SSC-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SSC-2980766:r:Nuclear Envelope Breakdown", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-2980766:r:Nuclear Envelope Breakdown", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-SSC-352238:r:Breakdown of the nuclear lamina", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-8950505:r:Gene and protein expression 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PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-5655862:r:Translesion synthesis by POLK", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-GGA-110312:r:Translesion synthesis by REV1", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-BTA-110331:r:Cleavage of the damaged purine", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-DDI-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-110331:r:Cleavage of the damaged purine", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-912446:r:Meiotic recombination", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-BTA-9670095:r:Inhibition of DNA recombination at telomere", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-5689901:r:Metalloprotease DUBs", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-110331:r:Cleavage of the damaged purine", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-SPO-69091:r:Polymerase switching", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-BTA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DDI-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-5696394:r:DNA Damage 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the telomere", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-RNO-5689901:r:Metalloprotease DUBs", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-GGA-353503:r:Translesion synthesis by Pol kappa", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DRE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-193648:r:NRAGE signals death through JNK", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9699150:r:Defective DNA double strand break response due to BARD1 loss of function", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base 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"R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DME-110320:r:Translesion Synthesis by POLH", "R-BTA-171306:r:Packaging Of Telomere Ends", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-DME-69091:r:Polymerase switching", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-110312:r:Translesion synthesis by REV1", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5689603:r:UCH proteinases", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-5689901:r:Metalloprotease DUBs", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-193648:r:NRAGE signals death through JNK", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-69091:r:Polymerase switching", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-BTA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-MMU-69091:r:Polymerase switching"], "type": "Homologous_superfamily"}, "IPR036421": {"description": "Iron dependent repressor, metal binding and dimerisation domain superfamily", "go_ids": ["GO:0046983", "GO:0046914"], "go_terms": ["GO:0046983:protein dimerization activity:F", "GO:0046914:transition metal ion binding:F"], "name": "Fe_dep_repressor_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036422": {"description": "RuBisCO large subunit, N-terminal domain superfamily", "go_ids": ["GO:0015977", "GO:0016984"], "go_terms": ["GO:0015977:carbon fixation:P", "GO:0016984:ribulose-bisphosphate carboxylase activity:F"], "name": "RuBisCO_lsu_N_sf", "pathway_ids": ["PWY-5723", "PWY-5532"], "pathways": ["PWY-5723:t:Rubisco shunt", "PWY-5532:t:nucleoside and nucleotide degradation (archaea)"], "type": "Homologous_superfamily"}, "IPR036423": {"description": "Superoxide dismutase-like, copper/zinc binding domain superfamily", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "SOD-like_Cu/Zn_dom_sf", "pathway_ids": ["PWY-6854", "R-HSA-9818027", "R-HSA-3299685", "R-DRE-114608", "R-DRE-3299685", "R-DME-114608", "R-SSC-114608", "R-CEL-114608", "R-HSA-8950505", "R-SCE-114608", "R-SSC-3299685", "R-CEL-3299685", "R-DDI-114608", "R-MMU-3299685", "R-RNO-3299685", "R-SPO-114608", "R-RNO-114608", "R-DDI-3299685", "R-HSA-114608", "R-BTA-114608", "R-SCE-3299685", "R-BTA-3299685", "R-SPO-3299685", "R-DME-3299685", "R-XTR-114608", "R-HSA-1222387", "R-XTR-3299685", "R-MMU-114608"], "pathways": ["PWY-6854:t:ethene biosynthesis III (microbes)", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-DRE-114608:r:Platelet degranulation", "R-DRE-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-114608:r:Platelet degranulation", "R-SSC-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-SCE-114608:r:Platelet degranulation", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-DDI-114608:r:Platelet degranulation", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-DDI-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-SCE-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SPO-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-3299685:r:Detoxification of Reactive Oxygen Species", "R-XTR-114608:r:Platelet degranulation", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages", "R-XTR-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036424": {"description": "Decaprenyl diphosphate synthase-like superfamily", "go_ids": ["GO:0016765"], "go_terms": ["GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "UPP_synth-like_sf", "pathway_ids": ["R-DRE-446199", "R-HSA-4755609", "R-MMU-446199", "R-SPO-446199", "R-HSA-446199", "R-SCE-446199"], "pathways": ["R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-4755609:r:Defective DHDDS causes RP59", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-446199:r:Synthesis of dolichyl-phosphate"], "type": "Homologous_superfamily"}, "IPR036425": {"description": "MoaB/Mog-like domain superfamily", "go_ids": [], "go_terms": [], "name": "MoaB/Mog-like_dom_sf", "pathway_ids": ["R-DRE-196843", "R-DME-947581", "R-CEL-196843", "R-MMU-196843", "R-MMU-947581", "R-RNO-196843", "R-RNO-947581", "R-DDI-947581", "R-HSA-196843", "R-HSA-947581"], "pathways": ["R-DRE-196843:r:Vitamin B2 (riboflavin) metabolism", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-CEL-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", 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"R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-DRE-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-XTR-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-1266695:r:Interleukin-7 signaling", "R-DME-3214858:r:RMTs methylate histone arginines", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-HSA-9818028:r:NFE2L2 regulates 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"R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "type": "Homologous_superfamily"}, "IPR036433": {"description": "Elongation factor EF1B gamma, C-terminal domain superfamily", "go_ids": ["GO:0003746", "GO:0006414"], "go_terms": ["GO:0003746:translation elongation factor activity:F", "GO:0006414:translational elongation:P"], "name": "EF1B_G_C_sf", "pathway_ids": ["R-SCE-156842", "R-HSA-156842", "R-MMU-156842", "R-DME-156842", "R-HSA-9725370", "R-RNO-156842"], "pathways": ["R-SCE-156842:r:Eukaryotic Translation Elongation", "R-HSA-156842:r:Eukaryotic Translation Elongation", "R-MMU-156842:r:Eukaryotic Translation Elongation", "R-DME-156842:r:Eukaryotic Translation Elongation", "R-HSA-9725370:r:Signaling by ALK fusions 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["R-HSA-6798695", "R-SPO-6798695", "R-SSC-6798695", "R-HSA-2122948", "R-HSA-9662834", "R-RNO-1474228", "R-CEL-6798695", "R-HSA-977225", "R-HSA-1251985", "R-BTA-6798695", "R-HSA-75893", "R-SSC-1474228", "R-RNO-193692", "R-SPO-8941237", "R-MMU-8957275", "R-BTA-8957275", "R-MMU-193692", "R-CEL-1474228", "R-HSA-2979096", "R-HSA-5362798", "R-HSA-9013700", "R-MMU-9013507", "R-MMU-8941237", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-RNO-8957275", "R-HSA-177929", "R-BTA-381426", "R-RNO-75893", "R-HSA-9013507", "R-HSA-2691232", "R-HSA-381426", "R-HSA-1442490", "R-MMU-1474228", "R-RNO-8941237", "R-HSA-1474228", "R-MMU-2534343", "R-MMU-75893", "R-SSC-381426", "R-SSC-8957275", "R-BTA-1474228", "R-HSA-2894862", "R-RNO-9013507", "R-MMU-9762292", "R-HSA-982772", "R-RNO-381426", "R-HSA-2534343", "R-HSA-2660826", "R-HSA-3928665", "R-HSA-8941237", "R-MMU-5682910", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-8957275", "R-HSA-2644606", "R-HSA-5682910", "R-HSA-193692", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-75893:r:TNF signaling", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-SPO-8941237:r:Invadopodia formation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-8941237:r:Invadopodia formation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-177929:r:Signaling by EGFR", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-75893:r:TNF signaling", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-RNO-8941237:r:Invadopodia formation", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-MMU-75893:r:TNF signaling", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8941237:r:Invadopodia formation", "R-MMU-5682910:r:LGI-ADAM interactions", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036437": {"description": "Outer surface protein C-like superfamily", "go_ids": ["GO:0009279"], "go_terms": ["GO:0009279:cell outer membrane:C"], "name": "OspC-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036438": {"description": "Insulin-like superfamily", "go_ids": [], "go_terms": [], "name": "Insulin-like_sf", "pathway_ids": ["R-DRE-74749", "R-MMU-6811558", "R-HSA-77387", "R-HSA-264876", "R-RNO-74752", "R-RNO-2428933", "R-MMU-74752", "R-GGA-422085", "R-CFA-77387", "R-RNO-74749", "R-CFA-2428933", "R-CFA-74752", "R-DRE-74713", "R-CFA-114608", "R-SSC-6811558", "R-MMU-422085", "R-RNO-6811558", "R-MMU-381426", "R-DRE-6807878", "R-CFA-74749", "R-MMU-74751", "R-SSC-2428928", "R-RNO-422085", "R-SSC-74752", "R-HSA-381426", "R-MMU-2428933", "R-RNO-2404192", "R-MMU-77387", "R-HSA-2404192", "R-SSC-74749", "R-HSA-74713", "R-SSC-381426", "R-SSC-2428933", "R-SSC-422085", "R-HSA-418555", "R-DRE-74752", "R-GGA-77387", "R-HSA-422085", "R-RNO-77387", "R-CFA-74713", "R-HSA-6811558", "R-RNO-381426", "R-DME-110478", "R-SSC-6807878", "R-BTA-418555", "R-MMU-264876", "R-DRE-422085", "R-DRE-77387", "R-GGA-74749", "R-HSA-9768919", "R-MMU-114608", "R-GGA-6807878", "R-RNO-264876", "R-CFA-2404192", "R-HSA-74751", "R-CFA-74751", "R-GGA-264876", "R-HSA-977225", "R-SSC-114608", "R-BTA-2428928", "R-CFA-264876", "R-HSA-2428933", "R-MMU-6807878", "R-CFA-422085", "R-GGA-74713", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-MMU-444821", "R-HSA-114608", "R-BTA-114608", "R-SSC-2404192", "R-HSA-9615017", "R-SSC-264876", "R-CFA-6811558", "R-BTA-381426", "R-MMU-2428928", "R-SSC-444821", "R-CFA-6807878", "R-GGA-74751", "R-CFA-381426", "R-MMU-74713", "R-SSC-77387", "R-RNO-6807878", "R-BTA-444821", "R-BTA-2428933", "R-HSA-6807878", "R-DME-444821", "R-HSA-210745", "R-HSA-444821", "R-HSA-74749", "R-BTA-2404192", "R-MMU-2404192", "R-RNO-74713", "R-CFA-2428928", "R-RNO-2428928", "R-BTA-422085", "R-HSA-418594", "R-RNO-74751", "R-HSA-74752", "R-SSC-74713", "R-GGA-74752", "R-CFA-444821", "R-DRE-264876", "R-SSC-418594", "R-HSA-2428928", "R-SSC-74751", "R-MMU-74749", "R-RNO-444821", "R-MMU-418555", "R-HSA-422356"], "pathways": ["R-DRE-74749:r:Signal attenuation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-264876:r:Insulin processing", "R-RNO-74752:r:Signaling by Insulin receptor", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-74752:r:Signaling by Insulin receptor", "R-GGA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-CFA-77387:r:Insulin receptor recycling", "R-RNO-74749:r:Signal attenuation", "R-CFA-2428933:r:SHC-related events triggered by IGF1R", "R-CFA-74752:r:Signaling by Insulin receptor", "R-DRE-74713:r:IRS activation", "R-CFA-114608:r:Platelet degranulation", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-CFA-74749:r:Signal attenuation", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-SSC-2428928:r:IRS-related events triggered by IGF1R", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-SSC-74752:r:Signaling by Insulin receptor", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-SSC-74749:r:Signal attenuation", "R-HSA-74713:r:IRS activation", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-2428933:r:SHC-related events triggered by IGF1R", "R-SSC-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-418555:r:G alpha (s) signalling events", "R-DRE-74752:r:Signaling by Insulin receptor", "R-GGA-77387:r:Insulin receptor recycling", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-77387:r:Insulin receptor recycling", "R-CFA-74713:r:IRS activation", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-110478:r:Insulin signaling pathway", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-BTA-418555:r:G alpha (s) signalling events", "R-MMU-264876:r:Insulin processing", "R-DRE-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-DRE-77387:r:Insulin receptor recycling", "R-GGA-74749:r:Signal attenuation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-MMU-114608:r:Platelet degranulation", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-RNO-264876:r:Insulin processing", "R-CFA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-CFA-74751:r:Insulin receptor signalling cascade", "R-GGA-264876:r:Insulin processing", "R-HSA-977225:r:Amyloid fiber formation", "R-SSC-114608:r:Platelet degranulation", "R-BTA-2428928:r:IRS-related events triggered by IGF1R", "R-CFA-264876:r:Insulin processing", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-GGA-74713:r:IRS activation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-MMU-444821:r:Relaxin receptors", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-SSC-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SSC-264876:r:Insulin processing", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-444821:r:Relaxin receptors", "R-CFA-6807878:r:COPI-mediated anterograde transport", "R-GGA-74751:r:Insulin receptor signalling cascade", "R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-74713:r:IRS activation", "R-SSC-77387:r:Insulin receptor recycling", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-BTA-444821:r:Relaxin receptors", "R-BTA-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-DME-444821:r:Relaxin receptors", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-444821:r:Relaxin receptors", "R-HSA-74749:r:Signal attenuation", "R-BTA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-RNO-74713:r:IRS activation", "R-CFA-2428928:r:IRS-related events triggered by IGF1R", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-HSA-74752:r:Signaling by Insulin receptor", "R-SSC-74713:r:IRS activation", "R-GGA-74752:r:Signaling by Insulin receptor", "R-CFA-444821:r:Relaxin receptors", "R-DRE-264876:r:Insulin processing", "R-SSC-418594:r:G alpha (i) signalling events", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-SSC-74751:r:Insulin receptor signalling cascade", "R-MMU-74749:r:Signal attenuation", "R-RNO-444821:r:Relaxin receptors", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Homologous_superfamily"}, "IPR036439": {"description": "Dockerin domain superfamily", "go_ids": ["GO:0000272"], "go_terms": ["GO:0000272:polysaccharide catabolic process:P"], "name": "Dockerin_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036440": {"description": "Peptidase C15, pyroglutamyl peptidase I-like superfamily", "go_ids": [], "go_terms": [], "name": "Peptidase_C15-like_sf", "pathway_ids": ["PWY-7942"], "pathways": ["PWY-7942:t:5-oxo-L-proline metabolism"], "type": "Homologous_superfamily"}, "IPR036441": {"description": "Dehydroquinase, class II superfamily", "go_ids": ["GO:0003855"], "go_terms": ["GO:0003855:3-dehydroquinate dehydratase activity:F"], "name": "DHquinase_II_sf", 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derived from an Intron-Containing Transcript", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CFA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-CFA-5689880:r:Ub-specific processing proteases", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-8951664:r:Neddylation", "R-CFA-9766229:r:Degradation of CDH1", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9629232:r:Defective Base Excision Repair Associated with NEIL3", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-69541:r:Stabilization of p53", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Homologous_superfamily"}, "IPR036444": {"description": "Phospholipase A2 domain superfamily", "go_ids": ["GO:0050482", "GO:0006644", "GO:0004623"], "go_terms": ["GO:0050482:arachidonate secretion:P", "GO:0006644:phospholipid metabolic process:P", "GO:0004623:A2-type glycerophospholipase activity:F"], "name": "PLipase_A2_dom_sf", "pathway_ids": ["PWY-8411", "PWY-8051", "PWY-7783", "PWY-7416", "PWY-8398", "PWY-7417", "PWY-8400", "PWY-8399", "PWY-7409", "PWY-6803", "PWY-8395", "PWY-8356", "PWY-8357", "PWY-8355", "PWY-8396", "PWY-8413", "PWY-8397", "PWY-8053", "PWY-8412", "PWY-8410", "R-BTA-6803157", "R-RNO-1483166", "R-BTA-1482788", "R-BTA-1482801", "R-CFA-1482788", "R-CFA-1482839", "R-HSA-9925561", "R-CFA-1482922", "R-HSA-1483166", "R-HSA-1482925", "R-RNO-1482788", "R-HSA-1482922", "R-CFA-1482925", "R-CFA-1483166", "R-HSA-6803157", "R-MMU-1482788", "R-BTA-1483166", "R-RNO-1482925", "R-MMU-6803157", "R-MMU-1482925", "R-RNO-1482801", "R-RNO-1482839", "R-RNO-6803157", "R-CFA-1482801", "R-RNO-1482922", "R-BTA-1482839", "R-BTA-1482925", "R-MMU-1482839", "R-HSA-1482801", "R-MMU-1483166", "R-MMU-1482922", "R-HSA-1482839", "R-BTA-1482922", "R-MMU-1482801", "R-HSA-1482788"], "pathways": ["PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-8051:t:anandamide biosynthesis I", "PWY-7783:t:plasmalogen degradation", "PWY-7416:t:phospholipid remodeling (phosphatidylcholine, yeast)", "PWY-8398:t:alpha-linolenate metabolites biosynthesis", "PWY-7417:t:phospholipid remodeling (phosphatidate, yeast)", "PWY-8400:t:docosahexaenoate metabolites biosynthesis", "PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-7409:t:phospholipid remodeling (phosphatidylethanolamine, yeast)", "PWY-6803:t:phosphatidylcholine acyl editing", "PWY-8395:t:linoleate metabolites biosynthesis", "PWY-8356:t:maresin biosynthesis", "PWY-8357:t:protectin biosynthesis", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-8413:t:representative whole plasma EPA-derived icosanoids", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-8412:t:representative whole plasma DHA-derived icosanoids", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "R-BTA-6803157:r:Antimicrobial peptides", "R-RNO-1483166:r:Synthesis of PA", "R-BTA-1482788:r:Acyl chain remodelling of PC", "R-BTA-1482801:r:Acyl chain remodelling of PS", "R-CFA-1482788:r:Acyl chain remodelling of PC", "R-CFA-1482839:r:Acyl chain remodelling of PE", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-CFA-1482922:r:Acyl chain remodelling of PI", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-CFA-1482925:r:Acyl chain remodelling of PG", "R-CFA-1483166:r:Synthesis of PA", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-BTA-1483166:r:Synthesis of PA", "R-RNO-1482925:r:Acyl chain remodelling of PG", "R-MMU-6803157:r:Antimicrobial peptides", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-RNO-1482801:r:Acyl chain remodelling of PS", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-RNO-6803157:r:Antimicrobial peptides", "R-CFA-1482801:r:Acyl chain remodelling of PS", "R-RNO-1482922:r:Acyl chain remodelling of PI", "R-BTA-1482839:r:Acyl chain remodelling of PE", "R-BTA-1482925:r:Acyl chain remodelling of PG", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-MMU-1483166:r:Synthesis of PA", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Homologous_superfamily"}, "IPR036445": {"description": "GPCR family 2, extracellular hormone receptor domain superfamily", "go_ids": ["GO:0004930", "GO:0016020"], "go_terms": ["GO:0004930:G protein-coupled receptor activity:F", "GO:0016020:membrane:C"], "name": "GPCR_2_extracell_dom_sf", "pathway_ids": ["R-MMU-416476", "R-DME-350379", "R-HSA-373080", "R-MMU-9856530", "R-DRE-419812", "R-CEL-6798695", "R-DME-9619665", "R-DME-350368", "R-HSA-416476", "R-MMU-373080", "R-BTA-420092", "R-DME-350376", "R-MMU-381676", "R-HSA-419812", "R-CFA-373080", "R-RNO-420092", "R-DME-350411", "R-HSA-420092", "R-DRE-9856530", "R-RNO-419812", "R-MMU-163359", "R-RNO-416476", "R-HSA-163359", "R-DME-450728", "R-CEL-373080", "R-CEL-9619665", "R-DME-6798695", "R-DME-373080", "R-HSA-418555", "R-DME-350480", "R-RNO-163359", "R-RNO-381676", "R-HSA-422085", "R-MMU-420092", "R-RNO-9856530", "R-MMU-419812", "R-CEL-419812", "R-HSA-187024", "R-HSA-381676", "R-BTA-418555", "R-RNO-373080", "R-HSA-9856530", "R-MMU-9619665", "R-MMU-418555"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DRE-419812:r:Calcitonin-like ligand receptors", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-BTA-420092:r:Glucagon-type ligand receptors", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-419812:r:Calcitonin-like ligand receptors", "R-CFA-373080:r:Class B/2 (Secretin family receptors)", "R-RNO-420092:r:Glucagon-type ligand receptors", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-HSA-420092:r:Glucagon-type ligand receptors", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-419812:r:Calcitonin-like ligand receptors", "R-MMU-163359:r:Glucagon signaling in metabolic regulation", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-DME-450728:r:Inhibition of actin polymerization", "R-CEL-373080:r:Class B/2 (Secretin family receptors)", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-418555:r:G alpha (s) signalling events", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-RNO-163359:r:Glucagon signaling in metabolic regulation", "R-RNO-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-420092:r:Glucagon-type ligand receptors", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-419812:r:Calcitonin-like ligand receptors", "R-CEL-419812:r:Calcitonin-like ligand receptors", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-BTA-418555:r:G alpha (s) signalling events", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Homologous_superfamily"}, "IPR036451": {"description": "Cobalamin adenosyltransferase-like superfamily", "go_ids": [], "go_terms": [], "name": "CblAdoTrfase-like_sf", "pathway_ids": ["R-HSA-9759218", "R-HSA-3359471", "R-MMU-9759218"], "pathways": ["R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-3359471:r:Defective MMAB causes MMA, cblB type", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism"], "type": "Homologous_superfamily"}, "IPR036452": {"description": "Ribonucleoside hydrolase-like", "go_ids": ["GO:0016799"], "go_terms": ["GO:0016799:hydrolase activity, hydrolyzing N-glycosyl compounds:F"], "name": "Ribo_hydro-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036453": {"description": "Glutamyl tRNA-reductase dimerization domain superfamily", "go_ids": ["GO:0033014", "GO:0008883", "GO:0050661"], "go_terms": ["GO:0033014:tetrapyrrole biosynthetic process:P", "GO:0008883:glutamyl-tRNA reductase activity:F", "GO:0050661:NADP binding:F"], "name": "GluRdtase_dimer_dom_sf", "pathway_ids": ["PWY-5188"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)"], "type": "Homologous_superfamily"}, "IPR036454": {"description": "Amyloidogenic glycoprotein, heparin-binding domain superfamily", "go_ids": ["GO:0008201"], "go_terms": ["GO:0008201:heparin binding:F"], "name": "Amyloid_glyco_heparin-bd_sf", "pathway_ids": ["R-MMU-416476", "R-SSC-432720", "R-DME-381426", "R-HSA-879415", "R-MMU-9837999", "R-MMU-444473", "R-DME-8957275", "R-HSA-3000178", "R-HSA-977225", "R-HSA-933542", "R-RNO-444473", "R-SSC-114608", "R-HSA-8862803", "R-CEL-3000178", "R-HSA-416476", "R-MMU-933542", "R-RNO-9609523", "R-DME-3000178", "R-MMU-418594", "R-MMU-8957275", "R-RNO-114608", "R-RNO-418594", "R-CEL-416476", "R-HSA-114608", "R-CEL-9609523", "R-MMU-445989", "R-MMU-3000178", "R-RNO-8957275", "R-SSC-933542", "R-MMU-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-444473", "R-DME-9609523", "R-HSA-9837999", "R-MMU-432720", "R-HSA-9609523", "R-MMU-9609523", "R-SSC-445989", "R-RNO-416476", "R-RNO-3000178", "R-HSA-381426", "R-SSC-3000178", "R-HSA-844456", "R-SSC-381426", "R-SSC-8957275", "R-RNO-432720", "R-HSA-432720", "R-DME-114608", "R-DME-9837999", "R-HSA-9660826", "R-MMU-879415", "R-HSA-445989", "R-SSC-9609523", "R-CEL-114608", "R-RNO-9837999", "R-SSC-879415", "R-RNO-381426", "R-HSA-418594", "R-RNO-879415", "R-RNO-445989", "R-SSC-9837999", "R-HSA-8957275", "R-RNO-933542", "R-MMU-114608"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-SSC-114608:r:Platelet degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DME-3000178:r:ECM proteoglycans", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-CEL-416476:r:G alpha (q) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-3000178:r:ECM proteoglycans", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-HSA-844456:r:The NLRP3 inflammasome", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-114608:r:Platelet degranulation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-114608:r:Platelet degranulation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036456": {"description": "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily", "go_ids": ["GO:0006396", "GO:0003723"], "go_terms": ["GO:0006396:RNA processing:P", "GO:0003723:RNA binding:F"], "name": "PNPase_PH_RNA-bd_sf", "pathway_ids": ["R-HSA-9836573"], "pathways": ["R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Homologous_superfamily"}, "IPR036457": {"description": "PPM-type phosphatase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "PPM-type-like_dom_sf", "pathway_ids": ["R-MMU-2173795", "R-HSA-9020702", "R-HSA-9705671", "R-HSA-168638", "R-HSA-9700645", "R-MMU-380972", "R-HSA-937042", "R-HSA-5689880", "R-SPO-5223345", "R-MMU-450302", "R-RNO-1169408", "R-MMU-5607764", "R-MMU-9645460", "R-MMU-9020702", "R-MMU-937072", "R-HSA-1169408", "R-MMU-5357956", "R-MMU-937042", "R-BTA-380972", "R-HSA-450321", "R-SPO-9013106", "R-HSA-2871837", "R-RNO-2173795", "R-MMU-5689880", "R-MMU-445989", "R-BTA-204174", "R-MMU-70895", "R-HSA-199418", "R-HSA-2173795", "R-HSA-450302", "R-SPO-983168", "R-MMU-975163", "R-HSA-8878166", "R-BTA-2173795", "R-MMU-168638", "R-SPO-6803207", "R-HSA-9617324", "R-HSA-937072", "R-HSA-5607764", "R-HSA-380972", "R-RNO-199418", "R-CEL-2173795", "R-BTA-70895", "R-HSA-204174", "R-RNO-204174", "R-HSA-445989", "R-CEL-380972", "R-MMU-450321", "R-HSA-1660661", "R-MMU-1169408", "R-HSA-9645460", "R-HSA-70895", "R-MMU-8878166", "R-CEL-6803207", "R-RNO-70895", "R-SPO-8980692", "R-SPO-9652282", "R-MMU-204174", "R-CEL-1169408", "R-HSA-5357956", "R-MMU-2871837", "R-RNO-380972", "R-SPO-199418", "R-HSA-9014325", "R-MMU-199418", "R-BTA-1169408", "R-HSA-9912529", "R-HSA-9725370", "R-HSA-975163"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SPO-5223345:r:Miscellaneous transport and binding events", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-SPO-9013106:r:RHOC GTPase cycle", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-CEL-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Homologous_superfamily"}, "IPR036458": {"description": "Sodium:dicarboxylate symporter superfamily", "go_ids": ["GO:0015293", "GO:0016020"], "go_terms": ["GO:0015293:symporter activity:F", "GO:0016020:membrane:C"], "name": "Na:dicarbo_symporter_sf", "pathway_ids": ["R-HSA-9013409", "R-BTA-210500", "R-MMU-210455", "R-CEL-352230", "R-HSA-5619067", "R-CEL-210500", "R-RNO-9013149", "R-BTA-9013406", "R-BTA-352230", "R-MMU-9958863", "R-MMU-352230", "R-RNO-210455", "R-CEL-9013149", "R-HSA-9013423", "R-CEL-9013407", "R-BTA-9013423", "R-HSA-352230", "R-RNO-352230", "R-BTA-210455", "R-HSA-210455", "R-CEL-9013406", "R-RNO-9013406", "R-HSA-210500", "R-HSA-5619062", "R-CEL-9013423", "R-BTA-9013407", "R-MMU-9013407", "R-RNO-210500", "R-RNO-9013407", "R-MMU-210500", "R-HSA-9958863", "R-BTA-9958863", "R-RNO-9958863", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013149", "R-CEL-210455", "R-MMU-9013406", "R-CEL-9958863", "R-HSA-9013406", "R-MMU-9013149", "R-HSA-9013407"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-352230:r:Amino acid transport across the plasma membrane", "R-HSA-5619067:r:Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-BTA-352230:r:Amino acid transport across the plasma membrane", "R-MMU-9958863:r:SLC-mediated transport of amino acids", "R-MMU-352230:r:Amino acid transport across the plasma membrane", "R-RNO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-9013407:r:RHOH GTPase cycle", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-BTA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-5619062:r:Defective SLC1A3 causes episodic ataxia 6 (EA6)", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9958863:r:SLC-mediated transport of amino acids", "R-BTA-9958863:r:SLC-mediated transport of amino acids", "R-RNO-9958863:r:SLC-mediated transport of amino acids", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-CEL-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-CEL-9958863:r:SLC-mediated transport of amino acids", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036459": {"description": "Viral capsid core domain supefamily, Hepatitis B virus", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Viral_capsid_core_dom_sf_HBV", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036460": {"description": "Copper amine oxidase, catalytic domain superfamily", "go_ids": ["GO:0009308", "GO:0005507", "GO:0008131", "GO:0048038"], "go_terms": ["GO:0009308:amine metabolic process:P", "GO:0005507:copper ion binding:F", "GO:0008131:primary methylamine oxidase activity:F", "GO:0048038:quinone binding:F"], "name": "Cu_amine_oxidase_C_sf", "pathway_ids": ["R-RNO-211945", "R-HSA-6798695", "R-MMU-6798695", "R-BTA-211945", "R-HSA-211945", "R-RNO-6798695", "R-MMU-211945"], "pathways": ["R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-211945:r:Phase I - Functionalization of compounds", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-211945:r:Phase I - Functionalization of compounds"], "type": "Homologous_superfamily"}, "IPR036461": {"description": "Urease, beta subunit superfamily", "go_ids": [], "go_terms": [], "name": "Urease_betasu_sf", "pathway_ids": ["PWY-5704"], "pathways": ["PWY-5704:t:urea degradation II"], "type": "Homologous_superfamily"}, "IPR036462": {"description": "Fumarylacetoacetase, N-terminal domain superfamily", "go_ids": ["GO:0009072", "GO:0004334"], "go_terms": ["GO:0009072:aromatic amino acid metabolic process:P", "GO:0004334:fumarylacetoacetase activity:F"], "name": "Fumarylacetoacetase_N_sf", "pathway_ids": ["R-HSA-8963684", "R-RNO-8963684", "R-CEL-8963684", "R-DDI-8963684", "R-MMU-8963684"], "pathways": ["R-HSA-8963684:r:Tyrosine catabolism", "R-RNO-8963684:r:Tyrosine catabolism", "R-CEL-8963684:r:Tyrosine catabolism", "R-DDI-8963684:r:Tyrosine catabolism", "R-MMU-8963684:r:Tyrosine catabolism"], "type": "Homologous_superfamily"}, "IPR036463": {"description": "Urease, gamma subunit superfamily", "go_ids": ["GO:0043419", "GO:0016151"], "go_terms": ["GO:0043419:urea catabolic process:P", "GO:0016151:nickel cation binding:F"], "name": "Urease_gamma_sf", "pathway_ids": ["PWY-5704"], "pathways": ["PWY-5704:t:urea degradation II"], "type": "Homologous_superfamily"}, "IPR036464": {"description": "Rubisco LSMT, substrate-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Rubisco_LSMT_subst-bd_sf", "pathway_ids": ["R-DRE-3214841", "R-MMU-3214841", "R-HSA-3214841", "R-RNO-3214841"], "pathways": ["R-DRE-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-RNO-3214841:r:PKMTs methylate histone lysines"], "type": "Homologous_superfamily"}, "IPR036465": {"description": "von Willebrand factor A-like domain superfamily", "go_ids": [], "go_terms": [], "name": "vWFA_dom_sf", "pathway_ids": ["R-DME-2173789", "R-CEL-73779", "R-DDI-983170", "R-HSA-73772", "R-HSA-8874081", "R-HSA-9013405", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-HSA-6802952", "R-RNO-372708", "R-HSA-140837", "R-BTA-1483206", "R-SCE-204005", "R-DDI-73776", "R-DDI-6782210", "R-CEL-1566948", "R-RNO-73776", "R-CEL-446343", "R-MMU-69473", "R-HSA-9662360", "R-DME-446343", "R-HSA-9846298", "R-HSA-8948216", "R-MMU-202733", "R-SSC-174577", "R-CEL-198933", "R-HSA-8875513", "R-SPO-6796648", "R-CEL-73776", "R-HSA-6802955", "R-HSA-210991", "R-RNO-446343", "R-BTA-977606", "R-RNO-5576892", "R-HSA-3270619", "R-BTA-75955", "R-DDI-6798695", "R-DME-432524", "R-DDI-204005", "R-HSA-6802948", "R-DME-210991", "R-CEL-5576892", "R-RNO-5696395", "R-MMU-9634597", "R-HSA-8949275", "R-HSA-196807", "R-BTA-5693565", "R-CEL-5674135", "R-HSA-419037", "R-MMU-173736", "R-DME-216083", "R-CEL-674695", 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"R-SPO-6782210", "R-HSA-76042", "R-HSA-674695", "R-SCE-73772", "R-BTA-216083", "R-HSA-186797", "R-HSA-6798695", "R-RNO-6807505", "R-RNO-674695", "R-MMU-76009", "R-DDI-5693571", "R-HSA-166016", "R-DME-198933", "R-MMU-5694530", "R-CEL-6798695", "R-MMU-5689901", "R-DRE-204005", "R-BTA-6798695", "R-RNO-3000157", "R-RNO-112308", "R-MMU-4420097", "R-HSA-6796648", "R-HSA-5694530", "R-HSA-6781823", "R-SPO-5696395", "R-HSA-167246", "R-MMU-5696395", "R-SCE-5694530", "R-HSA-5693607", "R-HSA-5576893", "R-CEL-202733", "R-HSA-446343", "R-MMU-381426", "R-CEL-381426", "R-HSA-75953", "R-HSA-9672391", "R-BTA-5693607", "R-RNO-9013408", "R-BTA-204005", "R-HSA-9013408", "R-SPO-72086", "R-RNO-9013404", "R-HSA-77075", "R-RNO-3000178", "R-HSA-212436", "R-RNO-6782210", "R-CEL-216083", "R-SPO-113418", "R-BTA-198933", "R-CEL-9860927", "R-DDI-73779", "R-BTA-72086", "R-HSA-9683610", "R-XTR-5694530", "R-RNO-5693607", "R-DDI-6781823", "R-SPO-5694530", "R-RNO-1566948", "R-RNO-73762", "R-RNO-69473", "R-MMU-6807505", "R-HSA-164843", "R-SCE-76042", "R-CEL-6781823", "R-HSA-204005", "R-RNO-381426", "R-DME-6807505", "R-CEL-5576893", "R-SSC-173736", "R-MMU-198933", "R-HSA-167200", "R-RNO-112382", "R-MMU-9013406", "R-MMU-6798695", "R-MMU-8875513", "R-DRE-5693565", "R-DME-209406", "R-HSA-112308", "R-MMU-5693571", "R-RNO-75953", "R-MMU-114608", "R-SCE-6782135", "R-DDI-6782135", "R-SPO-6798695", "R-HSA-2132295", "R-BTA-69473", "R-HSA-9725554", "R-BTA-173736", "R-BTA-113418", "R-BTA-3000178", "R-HSA-1566948", "R-HSA-9845621", "R-CEL-422356", "R-RNO-114608", "R-RNO-8875513", "R-HSA-210990", "R-DRE-2132295", "R-HSA-416700", "R-HSA-977606", "R-MMU-174577", "R-HSA-113418", "R-HSA-174577", "R-HSA-1834949", "R-DME-2129379", "R-DME-216167", "R-HSA-9938206", "R-HSA-1655829", "R-RNO-72086", "R-BTA-73762", "R-HSA-2214320", "R-XTR-204005", "R-CEL-210991", "R-HSA-216083", "R-GGA-353423", "R-HSA-445355", "R-GGA-6807505", "R-CEL-445144", "R-SCE-72086", "R-HSA-9927432", "R-HSA-73762", "R-CEL-77075", "R-SSC-977606", "R-DME-3000170", "R-CEL-4420097", "R-SCE-77075", "R-HSA-8957275", "R-HSA-9013406", "R-SPO-6782135", "R-DME-9013423", "R-MMU-2129379", "R-RNO-6781823", "R-HSA-9013409", "R-MMU-210991", "R-HSA-3000178", "R-RNO-73779", "R-HSA-427413", "R-RNO-5693565", "R-MMU-9013408", "R-MMU-210990", "R-CEL-3000178", "R-SPO-6781823", "R-MMU-445355", "R-HSA-9856532", "R-DME-445355", "R-HSA-167158", "R-RNO-5689901", "R-MMU-75955", "R-MMU-3000170", "R-MMU-112382", "R-HSA-5693565", "R-RNO-9634597", "R-SPO-76042", "R-CEL-2129379", "R-HSA-73776", "R-BTA-77075", "R-MMU-5576893", "R-DDI-674695", "R-RNO-210990", "R-CEL-75953", "R-HSA-166663", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-446107", "R-BTA-5689901", "R-BTA-73863", "R-GGA-1650814", "R-DME-9013149", "R-SSC-381426", "R-RNO-1566977", "R-BTA-75953", "R-RNO-445144", "R-BTA-1566948", "R-HSA-69473", "R-BTA-6782135", "R-DME-114608", "R-DME-209461", "R-HSA-400042", "R-CEL-6782210", "R-HSA-9609690", "R-RNO-5693571", "R-HSA-447041", "R-MMU-9013423", "R-HSA-167161", "R-HSA-2022090", "R-HSA-173736", "R-CEL-5696395", "R-HSA-167160", "R-MMU-983170", "R-HSA-5696395", "R-DDI-77075", "R-HSA-445144", "R-MMU-73772", "R-BTA-73776", "R-MMU-186797", "R-BTA-73772", "R-RNO-6798695", "R-MMU-446107", "R-MMU-9860927", "R-HSA-9656223", "R-SCE-73776", "R-HSA-9705671", "R-HSA-6781827", "R-HSA-9845620", "R-MMU-430116", "R-SCE-6798695", "R-HSA-2672351", "R-CEL-9907900", "R-CEL-73772", "R-HSA-9013423", "R-MMU-1483206", "R-BTA-6781823", "R-MMU-6781823", "R-MMU-8874081", "R-DME-9907900", "R-RNO-445355", "R-CEL-354192", "R-MMU-73776", "R-BTA-5696400", "R-GGA-381426", "R-HSA-167172", "R-BTA-2132295", "R-HSA-1442490", "R-BTA-212436", "R-DRE-8957275", "R-BTA-73779", "R-CEL-9013423", "R-MMU-5693607", "R-RNO-113418", "R-DME-209360", "R-CEL-75955", "R-MMU-977606", "R-HSA-2129379", "R-DME-202733", "R-RNO-446107", "R-DDI-9907900", "R-DME-446107", "R-DME-432626", "R-MMU-1236973", "R-BTA-174577", "R-HSA-5693571", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-MMU-1650814", "R-CEL-445355", "R-RNO-5696400", "R-BTA-5693571", "R-HSA-5663220", "R-HSA-5696400", "R-MMU-9013149", "R-RNO-3000170", "R-BTA-6807505", "R-HSA-202733", "R-HSA-112382", "R-HSA-73779", "R-HSA-422356", "R-HSA-1989781", "R-MMU-204005", "R-HSA-5674135", "R-SCE-75953", "R-MMU-113418", "R-CEL-354194", "R-HSA-430116", "R-BTA-76042", "R-MMU-166663", "R-DDI-1483206", "R-RNO-9013149", "R-RNO-73863", "R-MMU-9013404", "R-BTA-2173789", "R-HSA-9927418", "R-MMU-8957275", "R-HSA-1650814", "R-MMU-2214320", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-RNO-202733", "R-CEL-8957275", "R-GGA-8957275", "R-HSA-9926550", "R-CEL-112308", "R-HSA-5210891", "R-MMU-73779", "R-MMU-76042", "R-HSA-381426", "R-HSA-2173789", "R-SPO-75953", "R-HSA-9672393", "R-CEL-76042", "R-DRE-5689901", "R-MMU-9907900", "R-RNO-198933", "R-CEL-1236973", "R-RNO-76042", "R-MMU-166016", "R-DDI-5694530", "R-MMU-140837", "R-HSA-9845619", "R-CEL-114608", "R-HSA-1236973", "R-CEL-113418", "R-MMU-445144", "R-HSA-6785807", "R-DDI-72086", "R-DRE-983170", "R-DME-354192", "R-MMU-674695", "R-BTA-166016", "R-HSA-9694631", "R-HSA-9013404", "R-DDI-6807505", "R-HSA-75892", "R-HSA-9013149", "R-DME-445144", "R-BTA-5694530", "R-SCE-674695", "R-HSA-198933", "R-MMU-6782210", "R-HSA-9860927", "R-HSA-372708", "R-CEL-6796648", "R-RNO-4420097", "R-MMU-419037", "R-HSA-5689901", "R-MMU-73762", "R-MMU-6782135", "R-HSA-3000157", "R-MMU-8948216", "R-MMU-422356", "R-CEL-1566977", "R-MMU-5576892", "R-CEL-72086", "R-HSA-72086", "R-HSA-9845622", "R-DME-9860927", "R-RNO-354194", "R-HSA-5576892", "R-RNO-2129379", "R-CEL-9013149", "R-BTA-202733", "R-HSA-167162", "R-MMU-372708", "R-HSA-76009", "R-CEL-1474228", "R-DME-1236973", "R-BTA-114608", "R-HSA-6802946", "R-HSA-167152", "R-RNO-8957275", "R-HSA-9833110", "R-BTA-5696395", "R-MMU-446343", "R-SCE-6782210", "R-BTA-6796648", "R-MMU-112308", "R-SPO-983170", "R-HSA-354192", "R-SCE-6796648", "R-SPO-77075", "R-RNO-73772", "R-RNO-210991", "R-RNO-6782135", "R-HSA-1566977", "R-SCE-113418", "R-MMU-73863", "R-HSA-354194", "R-HSA-6782135", "R-HSA-9679191", "R-DME-538864", "R-BTA-983170", "R-HSA-9830674", "R-SCE-9907900", "R-SPO-5696400", "R-DME-432395", "R-DDI-75953", "R-MMU-1442490"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-1483206:r:Glycerophospholipid biosynthesis", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-1566948:r:Elastic fibre formation", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-8948216:r:Collagen chain trimerization", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-SSC-174577:r:Activation of C3 and C5", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-BTA-977606:r:Regulation of Complement cascade", "R-RNO-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-432524:r:Degradation of PER", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-210991:r:Basigin interactions", "R-CEL-5576892:r:Phase 0 - rapid depolarisation", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-8949275:r:RUNX3 Regulates Immune Response and Cell Migration", "R-HSA-196807:r:Nicotinate metabolism", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-419037:r:NCAM1 interactions", "R-MMU-173736:r:Alternative complement activation", "R-DME-216083:r:Integrin cell surface interactions", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-216083:r:Integrin cell surface interactions", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-1483206:r:Glycerophospholipid biosynthesis", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-354192:r:Integrin signaling", "R-HSA-9634597:r:GPER1 signaling", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9907900:r:Proteasome assembly", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-2672351:r:Stimuli-sensing channels", "R-RNO-354192:r:Integrin signaling", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-3000170:r:Syndecan interactions", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-1566977:r:Fibronectin matrix formation", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-5694530:r:Cargo concentration in the ER", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-422356:r:Regulation of insulin secretion", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-166663:r:Initial triggering of complement", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-5689901:r:Metalloprotease DUBs", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000157:r:Laminin interactions", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SCE-5694530:r:Cargo concentration in the ER", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SPO-72086:r:mRNA Capping", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-212436:r:Generic Transcription Pathway", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-216083:r:Integrin cell surface interactions", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates 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"type": "Homologous_superfamily"}, "IPR036470": {"description": "Elicitin superfamily", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Elicitin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036471": {"description": "Colicin D superfamily", "go_ids": [], "go_terms": [], "name": "Colicin_D_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036472": {"description": "Cholecystokinin A receptor, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CholecystokininA_recpt_N_sf", "pathway_ids": ["R-MMU-416476", "R-HSA-416476", "R-HSA-375276", "R-MMU-375276", "R-RNO-375276", "R-RNO-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-RNO-416476:r:G alpha (q) signalling events"], "type": "Homologous_superfamily"}, "IPR036473": {"description": "Molybdopterin cofactor biosynthesis MoaD-related, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Mopterin_CF_MoaD-rel_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036474": {"description": "Transcription regulator MotA, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MotA_Tscrpt_reg_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036475": {"description": "Mitogen Ypm superfamily", "go_ids": [], "go_terms": [], "name": "Mitogen_Ypm_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036476": {"description": "Talin, central domain superfamily", "go_ids": [], "go_terms": [], "name": "Talin_cent_sf", "pathway_ids": ["R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-9656223", "R-MMU-399955", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036477": {"description": "Formyl transferase, N-terminal domain superfamily", "go_ids": ["GO:0009058"], "go_terms": ["GO:0009058:biosynthetic process:P"], "name": "Formyl_transf_N_sf", "pathway_ids": ["R-DME-73817", "R-MMU-196757", "R-HSA-5368286", "R-RNO-196757", "R-BTA-73817", "R-MMU-73817", "R-XTR-196757", "R-HSA-73817", "R-HSA-196757", "R-GGA-419140"], "pathways": ["R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-196757:r:Metabolism of folate and pterines", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-RNO-196757:r:Metabolism of folate and pterines", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-XTR-196757:r:Metabolism of folate and pterines", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-196757:r:Metabolism of folate and pterines", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Homologous_superfamily"}, "IPR036478": {"description": "Exotoxin A, middle domain superfamily", "go_ids": [], "go_terms": [], "name": "Exotox-A_middle_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036479": {"description": "Heat-stable enterotoxin B superfamily", "go_ids": [], "go_terms": [], "name": "STb_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036480": {"description": "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CarbP_synth_ssu_N_sf", "pathway_ids": ["PWY-7400", "PWY-7791", "PWY-5686", "PWY-7790", "PWY-5154", "R-MMU-500753", "R-MMU-70635", "R-DME-500753", "R-HSA-500753", "R-SCE-500753", "R-SPO-500753", "R-CEL-500753", "R-HSA-70635", "R-DDI-500753", "R-HSA-9955542", "R-RNO-70635"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-MMU-500753:r:Pyrimidine biosynthesis", "R-MMU-70635:r:Urea cycle", "R-DME-500753:r:Pyrimidine biosynthesis", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-SCE-500753:r:Pyrimidine biosynthesis", "R-SPO-500753:r:Pyrimidine biosynthesis", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-HSA-70635:r:Urea cycle", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-HSA-9955542:r:CPS1 variants cause CPS1 deficiency", "R-RNO-70635:r:Urea cycle"], "type": "Homologous_superfamily"}, "IPR036481": {"description": "Bcr-Abl oncoprotein oligomerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "Bcr-Abl_oncoprot_oligo_sf", "pathway_ids": ["R-RNO-9013026", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-9013149", "R-RNO-9013148", "R-HSA-9013106", "R-MMU-9013148", "R-MMU-9013404", "R-RNO-9013423", "R-HSA-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-MMU-9013423", "R-HSA-8980692", "R-MMU-9013026", "R-HSA-9013148", "R-HSA-9013026", "R-RNO-9013404", "R-RNO-9013106", "R-MMU-9013149", "R-HSA-5655302", "R-HSA-1839117"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Homologous_superfamily"}, "IPR036482": {"description": "Hut operon regulatory protein HutP superfamily", "go_ids": [], "go_terms": [], "name": "Regulatory_HutP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036483": {"description": "PWI domain superfamily", "go_ids": [], "go_terms": [], "name": "PWI_dom_sf", "pathway_ids": ["R-HSA-72163", "R-MMU-9013422", "R-HSA-9013422", "R-MMU-72187", "R-HSA-9770562", "R-HSA-9013418", "R-MMU-9770562", "R-MMU-72163", "R-MMU-73856", "R-HSA-73856", "R-HSA-159236", "R-HSA-72187", "R-MMU-9013418", "R-HSA-9918481", "R-MMU-159236"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Homologous_superfamily"}, "IPR036484": {"description": "Protein-tyrosine phosphatase, YopH, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ProtTyrPase_YopH_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036485": {"description": "Glutamate synthase, alpha subunit, C-terminal domain superfamily", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Glu_synth_asu_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036486": {"description": "Anti-Sigma Factor A superfamily", "go_ids": [], "go_terms": [], "name": "AsiA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036487": {"description": "Quinohemoprotein amine dehydrogenase, gamma subunit structural domain superfamily", "go_ids": [], "go_terms": [], "name": "QH-AmDH_gsu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036488": {"description": "DUF1883-like superfamily", "go_ids": [], "go_terms": [], "name": "DUF1883-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036489": {"description": "YoaG superfamily", "go_ids": [], "go_terms": [], "name": "YoaG_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036490": {"description": "Thoeris protein ThsB, TIR-like domain superfamily", "go_ids": [], "go_terms": [], "name": "ThsB_TIR-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036491": {"description": "YugN-like superfamily", "go_ids": [], "go_terms": [], "name": "YugN-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036492": {"description": "Hypothetical protein YojF superfamily", "go_ids": [], "go_terms": [], "name": "YojF_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036493": {"description": "Hypothetical protein YunC superfamily", "go_ids": [], "go_terms": [], "name": "YunC_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036494": {"description": "Ku, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Ku_C_sf", "pathway_ids": ["R-HSA-3270619", "R-HSA-6798695", "R-HSA-5693571", "R-DDI-6798695", "R-SPO-6798695", "R-DDI-5693571", "R-HSA-1834949", "R-MMU-6798695", "R-MMU-5693571", "R-HSA-164843"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Homologous_superfamily"}, "IPR036495": {"description": "ORF7a superfamily, coronavirus", "go_ids": [], "go_terms": [], "name": "ORF7a_sf_CoV", "pathway_ids": ["R-HSA-9754560", "R-HSA-9679509", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9692916", "R-HSA-166662", "R-HSA-166663", "R-HSA-9727281", "R-HSA-9694614", "R-HSA-9694322", "R-HSA-9692913"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy", "R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9727281:r:Translation of Accessory Proteins", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death"], "type": "Homologous_superfamily"}, "IPR036496": {"description": "Cathepsin C, exclusion domain superfamily", "go_ids": [], "go_terms": [], "name": "CathepsinC_exc_dom_sf", "pathway_ids": ["R-HSA-204005", "R-HSA-6798695", "R-MMU-204005", "R-RNO-2132295", "R-HSA-2132295", "R-RNO-5694530", "R-MMU-2132295", "R-MMU-5694530", "R-HSA-5694530", "R-MMU-6798695", "R-RNO-204005", "R-RNO-6798695"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-5694530:r:Cargo concentration in the ER", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036497": {"description": "Glycolipid transfer protein superfamily", "go_ids": [], "go_terms": [], "name": "GLTP_sf", "pathway_ids": ["R-BTA-9845576", "R-BTA-1660499", "R-RNO-1660499", "R-HSA-9845576", "R-CFA-1660499", "R-RNO-9845576", "R-CFA-9845576", "R-MMU-9845576", "R-DRE-1660499", "R-HSA-1660499", "R-XTR-9845576", "R-DRE-9845576", "R-MMU-1660499"], "pathways": ["R-BTA-9845576:r:Glycosphingolipid transport", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9845576:r:Glycosphingolipid transport", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9845576:r:Glycosphingolipid transport", "R-CFA-9845576:r:Glycosphingolipid transport", "R-MMU-9845576:r:Glycosphingolipid transport", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-XTR-9845576:r:Glycosphingolipid transport", "R-DRE-9845576:r:Glycosphingolipid transport", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Homologous_superfamily"}, "IPR036498": {"description": "Scaffold protein Nfu/NifU, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Nfu/NifU_N_sf", "pathway_ids": ["R-DME-9857492", "R-MMU-9857492", "R-SCE-9857492", "R-HSA-9857492"], "pathways": ["R-DME-9857492:r:Protein lipoylation", "R-MMU-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-HSA-9857492:r:Protein lipoylation"], "type": "Homologous_superfamily"}, "IPR036499": {"description": "Non-structural protein NSP9 superfamily, coronavirus", "go_ids": [], "go_terms": [], "name": "NSP9_sf_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR036501": {"description": "Inhibitor of vertebrate lysozyme superfamily", "go_ids": [], "go_terms": [], "name": "Inhibitor_vert_lysozyme_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036502": {"description": "Nickel-containing superoxide dismutase superfamily", "go_ids": [], "go_terms": [], "name": "NiSOD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036503": {"description": "Aldehyde ferredoxin oxidoreductase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Ald_Fedxn_OxRdtase_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036504": {"description": "CGI121/TPRKB superfamily", "go_ids": [], "go_terms": [], "name": "CGI121/TPRKB_sf", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Homologous_superfamily"}, "IPR036505": {"description": "N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily", "go_ids": ["GO:0008745", "GO:0009253"], "go_terms": ["GO:0008745:N-acetylmuramoyl-L-alanine amidase activity:F", "GO:0009253:peptidoglycan catabolic process:P"], "name": "Amidase/PGRP_sf", "pathway_ids": ["PWY-7883", "R-HSA-6798695", "R-RNO-6803157", "R-DME-214411", "R-BTA-6803157", "R-DME-214397", "R-DME-6798695", "R-DME-209266", "R-BTA-6798695", "R-DME-6803157", "R-HSA-6803157", "R-MMU-6798695", "R-DME-214399", "R-MMU-6803157", "R-DME-214416", "R-RNO-6798695", "R-DME-209171"], "pathways": ["PWY-7883:t:peptidoglycan recycling II", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-BTA-6803157:r:Antimicrobial peptides", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-209266:r:Peptidoglycan bound PGRP-LC/LE oligomerises", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-MMU-6803157:r:Antimicrobial peptides", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-209171:r:Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE"], "type": "Homologous_superfamily"}, "IPR036507": {"description": "Telomere repeat-binding factor, dimerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "Telomere_rpt-bd_fac_dimer_sf", "pathway_ids": ["R-MMU-174430", "R-HSA-174414", "R-MMU-174417", "R-HSA-1221632", "R-MMU-110331", "R-MMU-9670095", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-MMU-110330", "R-HSA-171306", "R-MMU-2559586", "R-HSA-174430", "R-HSA-110328", "R-HSA-174411", "R-MMU-171319", "R-HSA-9670095", "R-GGA-418124", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-1221632:r:Meiotic synapsis", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-GGA-418124:r:Telomere maintenance", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Homologous_superfamily"}, "IPR036508": {"description": "Chitin binding domain superfamily", "go_ids": ["GO:0008061"], "go_terms": ["GO:0008061:chitin binding:F"], "name": "Chitin-bd_dom_sf", "pathway_ids": ["R-CEL-189085", "R-HSA-6798695", "R-HSA-189085", "R-DME-6798695", "R-CEL-6798695", "R-MMU-6798695", "R-RNO-189085", "R-MMU-189085", "R-DME-189085"], "pathways": ["R-CEL-189085:r:Digestion of dietary carbohydrate", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-DME-189085:r:Digestion of dietary carbohydrate"], "type": "Homologous_superfamily"}, "IPR036509": {"description": "Peptide methionine sulphoxide reductase MsrA superfamily", "go_ids": ["GO:0008113"], "go_terms": ["GO:0008113:peptide-methionine (S)-S-oxide reductase activity:F"], "name": "Met_Sox_Rdtase_MsrA_sf", "pathway_ids": ["R-MMU-5676934", "R-BTA-5676934", "R-HSA-1222538", "R-HSA-5676934", "R-RNO-5676934"], "pathways": ["R-MMU-5676934:r:Protein repair", "R-BTA-5676934:r:Protein repair", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages", "R-HSA-5676934:r:Protein repair", "R-RNO-5676934:r:Protein repair"], "type": "Homologous_superfamily"}, "IPR036510": {"description": "Small ribosomal subunit protein bS20 superfamily", "go_ids": ["GO:0006412", "GO:0003735", "GO:0003723", "GO:0005840"], "go_terms": ["GO:0006412:translation:P", "GO:0003735:structural constituent of ribosome:F", "GO:0003723:RNA binding:F", "GO:0005840:ribosome:C"], "name": "Ribosomal_bS20_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036511": {"description": "Queuine tRNA-ribosyltransferase-like", "go_ids": ["GO:0006400"], "go_terms": ["GO:0006400:tRNA modification:P"], "name": "TGT-like_sf", "pathway_ids": ["PWY-6700", "PWY-8106", "R-HSA-6782315"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Homologous_superfamily"}, "IPR036512": {"description": "Photosystem II PsbZ superfamily", "go_ids": ["GO:0042549", "GO:0015979", "GO:0009539", "GO:0009523"], "go_terms": ["GO:0042549:photosystem II stabilization:P", "GO:0015979:photosynthesis:P", "GO:0009539:photosystem II reaction center:C", "GO:0009523:photosystem II:C"], "name": "PSII_PsbZ_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036513": {"description": "STAS domain superfamily", "go_ids": [], "go_terms": [], "name": "STAS_dom_sf", "pathway_ids": ["R-SCE-427601", "R-CEL-427601", "R-HSA-3560792", "R-SPO-427601", "R-BTA-174362", "R-SCE-174362", "R-HSA-5619085", "R-HSA-9662361", "R-BTA-427601", "R-HSA-5619046", "R-RNO-427601", "R-SPO-174362", "R-CEL-174362", "R-HSA-427601", "R-DRE-427601", "R-MMU-174362", "R-HSA-174362", "R-MMU-427601", "R-RNO-174362"], "pathways": ["R-SCE-427601:r:Inorganic anion exchange by SLC26 transporters", "R-CEL-427601:r:Inorganic anion exchange by SLC26 transporters", "R-HSA-3560792:r:Defective SLC26A2 causes chondrodysplasias", "R-SPO-427601:r:Inorganic anion exchange by SLC26 transporters", "R-BTA-174362:r:Transport and metabolism of PAPS", "R-SCE-174362:r:Transport and metabolism of PAPS", "R-HSA-5619085:r:Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-BTA-427601:r:Inorganic anion exchange by SLC26 transporters", "R-HSA-5619046:r:Defective SLC26A4 causes Pendred syndrome (PDS)", "R-RNO-427601:r:Inorganic anion exchange by SLC26 transporters", "R-SPO-174362:r:Transport and metabolism of PAPS", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-HSA-427601:r:Inorganic anion exchange by SLC26 transporters", "R-DRE-427601:r:Inorganic anion exchange by SLC26 transporters", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-MMU-427601:r:Inorganic anion exchange by SLC26 transporters", "R-RNO-174362:r:Transport and metabolism of PAPS"], "type": "Homologous_superfamily"}, "IPR036514": {"description": "SGNH hydrolase superfamily", "go_ids": [], "go_terms": [], "name": "SGNH_hydro_sf", "pathway_ids": ["R-RNO-6811436", "R-HSA-6798695", "R-RNO-1482788", "R-MMU-975634", "R-BTA-6811436", "R-DME-6811436", "R-DME-6798695", "R-MMU-1482788", "R-MMU-6798695", "R-RNO-975634", "R-BTA-6798695", "R-HSA-975634", "R-HSA-6811436", "R-RNO-6798695", "R-MMU-6811436", "R-HSA-1482788"], "pathways": ["R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-MMU-975634:r:Retinoid metabolism and transport", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975634:r:Retinoid metabolism and transport", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Homologous_superfamily"}, "IPR036515": {"description": "Transposase IS200-like superfamily", "go_ids": ["GO:0006313", "GO:0003677", "GO:0004803"], "go_terms": ["GO:0006313:DNA transposition:P", "GO:0003677:DNA binding:F", "GO:0004803:transposase activity:F"], "name": "Transposase_17_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036516": {"description": "Translation repressor RegA superfamily", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Transl_repress_RegA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036517": {"description": "FF domain superfamily", "go_ids": [], "go_terms": [], "name": "FF_domain_sf", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9013405", "R-CFA-9013409", "R-MMU-9013106", "R-RNO-9013409", "R-MMU-9770562", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9013409", "R-MMU-9013404", "R-RNO-416550", "R-HSA-8849471", "R-DME-9035034", "R-DME-9013148", "R-CFA-9013408", "R-CEL-9770562", "R-RNO-9013408", "R-RNO-9013406", "R-RNO-9013404", "R-HSA-9013408", "R-MMU-8849471", "R-MMU-9035034", "R-DME-9013149", "R-CFA-9013406", "R-CFA-9013148", "R-CFA-8980692", "R-DME-8980692", "R-MMU-72163", "R-RNO-9013148", "R-RNO-9696273", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-SPO-9770562", "R-HSA-72163", "R-HSA-9013149", "R-HSA-8980692", "R-CFA-9013106", "R-MMU-9013406", "R-RNO-9696264", "R-HSA-9013026", "R-MMU-9696264", "R-MMU-416550", "R-HSA-416550", "R-RNO-9696270", "R-MMU-8980692", "R-RNO-8980692", "R-CFA-9013404", "R-MMU-9013148", "R-HSA-9013106", "R-CFA-9013149", "R-HSA-9013423", "R-CFA-8849471", "R-CFA-9696264", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013409", "R-DME-9013406", "R-RNO-9013106", "R-CFA-9696270", "R-DME-350407", "R-RNO-8849471", "R-HSA-9770562", "R-HSA-9696270", "R-CFA-416550", "R-CFA-9696273", "R-RNO-9013423", "R-MMU-9013026", "R-DME-8849471", "R-MMU-9696270", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9013149", "R-DME-9013423", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-CFA-9013409:r:RHOJ GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-9035034:r:RHOF GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-CFA-9013408:r:RHOG GTPase cycle", "R-CEL-9770562:r:mRNA Polyadenylation", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-CFA-8980692:r:RHOA GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-9696264:r:RND3 GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-CFA-9696270:r:RND2 GTPase cycle", "R-DME-350407:r:RHO1 GTPase cycle", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9696273:r:RND1 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036518": {"description": "CobE/GbiG C-terminal domain superfamily", "go_ids": ["GO:0009236"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P"], "name": "CobE/GbiG_C_sf", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Homologous_superfamily"}, "IPR036519": {"description": "Uncharacterised UPF0058 superfamily", "go_ids": [], "go_terms": [], "name": "UPF0058_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036520": {"description": "UPF0759 superfamily", "go_ids": [], "go_terms": [], "name": "UPF0759_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036521": {"description": "Signal recognition particle, subunit SRP19-like superfamily", "go_ids": ["GO:0006614", "GO:0008312", "GO:0048500"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P", "GO:0008312:7S RNA binding:F", "GO:0048500:signal recognition particle:C"], "name": "SRP19-like_sf", "pathway_ids": ["R-HSA-1799339", "R-DME-1799339", "R-SPO-1799339", "R-CEL-1799339", "R-SCE-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-BTA-1799339", "R-MMU-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Homologous_superfamily"}, "IPR036522": {"description": "Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily", "go_ids": ["GO:0006777"], "go_terms": ["GO:0006777:Mo-molybdopterin cofactor biosynthetic process:P"], "name": "MoaC_sf", "pathway_ids": ["PWY-6823", "R-DME-947581", "R-BTA-947581", "R-DDI-947581", "R-HSA-947581", "R-MMU-947581"], "pathways": ["PWY-6823:t:molybdopterin biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Homologous_superfamily"}, "IPR036523": {"description": "SurE-like phosphatase/nucleotidase superfamily", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "SurE-like_sf", "pathway_ids": ["PWY-7821", "PWY-7185", "PWY-5381", "PWY-6596", "PWY-5695", "PWY-6607", "PWY-6608", "PWY-6606"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-5381:t:NAD salvage (plants)", "PWY-6596:t:adenosine nucleotides degradation I", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II"], "type": "Homologous_superfamily"}, "IPR036524": {"description": "Frataxin/CyaY superfamily", "go_ids": ["GO:0016226", "GO:0008199"], "go_terms": ["GO:0016226:iron-sulfur cluster assembly:P", "GO:0008199:ferric iron binding:F"], "name": "Frataxin/CyaY_sf", "pathway_ids": ["R-HSA-1362409", "R-HSA-9865881", "R-HSA-9854311", "R-RNO-1268020", "R-BTA-9854311", 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"R-XTR-5620924:r:Intraflagellar transport", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-PFA-6798695:r:Neutrophil degranulation", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-PFA-5620920:r:Cargo trafficking to the periciliary membrane", "R-RNO-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-PFA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR036526": {"description": "Carbon-nitrogen hydrolase superfamily", "go_ids": [], "go_terms": [], "name": "C-N_Hydrolase_sf", "pathway_ids": ["R-SPO-196807", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-MMU-196807", "R-DME-196780", "R-MMU-163125", "R-DDI-73621", 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regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Homologous_superfamily"}, "IPR036531": {"description": "Rabenosyn, Rab binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Rbsn_Rab-bd_sf", "pathway_ids": ["R-HSA-983231", "R-HSA-168138", "R-MMU-168138", "R-MMU-983231", "R-SCE-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Homologous_superfamily"}, "IPR036532": {"description": "AvrPto superfamily", "go_ids": [], "go_terms": [], "name": "AvrPto_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036533": {"description": "BAG domain superfamily", "go_ids": ["GO:0051087"], "go_terms": ["GO:0051087:protein-folding chaperone binding:F"], "name": "BAG_dom_sf", "pathway_ids": ["R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-MMU-75893", "R-HSA-75893", "R-HSA-5655302", "R-CEL-3371453", "R-HSA-8853336", "R-MMU-3371453"], "pathways": ["R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-75893:r:TNF signaling", "R-HSA-75893:r:TNF signaling", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Homologous_superfamily"}, "IPR036534": {"description": "GAR domain superfamily", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "GAR_dom_sf", "pathway_ids": ["R-HSA-9013420", "R-HSA-2022090", "R-MMU-9013420", "R-MMU-446107", "R-HSA-9696270", "R-MMU-264870", "R-MMU-9013424", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-264870", "R-HSA-9013424", "R-HSA-446107", "R-MMU-9696273", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-9013420:r:RHOU GTPase cycle", "R-MMU-446107:r:Type I hemidesmosome assembly", 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"R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DME-8985947:r:Interleukin-9 signaling", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-8983432:r:Interleukin-15 signaling", "R-BTA-8983432:r:Interleukin-15 signaling", "R-RNO-9020958:r:Interleukin-21 signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-DME-1059683:r:Interleukin-6 signaling", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DME-6783783:r:Interleukin-10 signaling", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DME-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-SSC-1266695:r:Interleukin-7 signaling", "R-BTA-8985947:r:Interleukin-9 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-MMU-9020956:r:Interleukin-27 signaling", "R-SSC-912694:r:Regulation of IFNA/IFNB signaling", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-210671:r:Transcriptional repression by nuclear factors", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-MMU-877312:r:Regulation of IFNG signaling", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-SSC-1059683:r:Interleukin-6 signaling", "R-RNO-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-8849474:r:PTK6 Activates STAT3", "R-DME-8983432:r:Interleukin-15 signaling", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-201556:r:Signaling by ALK", "R-HSA-877300:r:Interferon gamma 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"R-HSA-9020933:r:Interleukin-23 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-BTA-8854691:r:Interleukin-20 family signaling", "R-SSC-8849474:r:PTK6 Activates STAT3", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-SSC-201556:r:Signaling by ALK", "R-RNO-1059683:r:Interleukin-6 signaling", "R-SSC-6783783:r:Interleukin-10 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-186763:r:Downstream signal transduction", "R-SSC-8985947:r:Interleukin-9 signaling", "R-DME-8984722:r:Interleukin-35 Signalling", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-SSC-9020958:r:Interleukin-21 signaling", "R-DME-9020956:r:Interleukin-27 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-9020591:r:Interleukin-12 signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-9645135:r:STAT5 Activation", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-SSC-9008059:r:Interleukin-37 signaling", "R-SSC-9020956:r:Interleukin-27 signaling", "R-DME-909733:r:Interferon alpha/beta signaling", "R-BTA-9020958:r:Interleukin-21 signaling", "R-DME-9008059:r:Interleukin-37 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-877312:r:Regulation of IFNG signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DME-8854691:r:Interleukin-20 family signaling", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DME-9020591:r:Interleukin-12 signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-SSC-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-8875791:r:MET activates STAT3", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-DME-201556:r:Signaling by ALK", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-9008059:r:Interleukin-37 signaling", "R-RNO-9008059:r:Interleukin-37 signaling"], "type": "Homologous_superfamily"}, "IPR036537": {"description": "Adaptor protein Cbl, N-terminal domain superfamily", "go_ids": ["GO:0007166"], "go_terms": ["GO:0007166:cell surface receptor signaling pathway:P"], "name": "Adaptor_Cbl_N_dom_sf", "pathway_ids": ["PWY-7511", "R-HSA-8849469", "R-MMU-8856828", "R-MMU-182971", "R-MMU-1433559", "R-HSA-1059683", "R-MMU-8856825", "R-HSA-8856828", "R-HSA-912631", "R-MMU-1295596", "R-HSA-9686347", "R-MMU-5213460", "R-HSA-1236382", "R-MMU-3295583", "R-RNO-983168", "R-MMU-5654732", "R-HSA-2173789", "R-HSA-9706369", "R-MMU-912631", "R-HSA-182971", "R-HSA-5654727", "R-MMU-2173789", "R-MMU-8849469", "R-HSA-168276", "R-HSA-5654726", "R-HSA-5675482", "R-HSA-5654732", "R-MMU-5675482", "R-MMU-9706369", "R-HSA-6807004", "R-HSA-983168", "R-HSA-5637810", "R-HSA-9706377", "R-MMU-5654726", "R-HSA-5213460", "R-HSA-1433559", "R-MMU-1059683", "R-HSA-1295596", "R-HSA-8856825", "R-MMU-5654727", "R-MMU-983168", "R-MMU-5654733", "R-MMU-6807004", "R-HSA-5654733", "R-HSA-8875360", "R-HSA-9680350", "R-HSA-3295583"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-182971:r:EGFR downregulation", "R-MMU-1433559:r:Regulation of KIT signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-3295583:r:TRP channels", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-912631:r:Regulation of signaling by CBL", "R-HSA-182971:r:EGFR downregulation", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-1433559:r:Regulation of KIT signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-3295583:r:TRP channels"], "type": "Homologous_superfamily"}, "IPR036538": {"description": "Alpha trans-inducing (Alpha-TIF) superfamily", "go_ids": ["GO:0006355", "GO:0003677"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F"], "name": "Alpha_TIF_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036539": {"description": "Cytochrome c oxidase, subunit VIIa superfamily", "go_ids": ["GO:0045277", "GO:0006123"], "go_terms": ["GO:0045277:respiratory chain complex IV:C", "GO:0006123:mitochondrial electron transport, cytochrome c to oxygen:P"], "name": "Cyt_c_oxidase_su7a_sf", "pathway_ids": ["R-SSC-611105", "R-DRE-611105", "R-DME-9707564", "R-SSC-5628897", "R-DRE-9864848", "R-RNO-5628897", "R-SSC-9864848", "R-RNO-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-BTA-5628897", "R-DME-611105", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-SSC-9707564", "R-DME-9864848", "R-HSA-9844594", "R-BTA-611105", "R-HSA-9707564", "R-MMU-5628897", "R-MMU-611105", "R-MMU-9864848", "R-DRE-9707564", "R-DME-5628897", "R-MMU-9707564", "R-DRE-5628897", "R-BTA-9707564"], "pathways": ["R-SSC-611105:r:Respiratory electron transport", "R-DRE-611105:r:Respiratory electron transport", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-611105:r:Respiratory electron transport", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-SSC-9707564:r:Cytoprotection by HMOX1", "R-DME-9864848:r:Complex IV assembly", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-BTA-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-9864848:r:Complex IV assembly", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR036540": {"description": "Poxvirus chemokine inhibitor superfamily", "go_ids": [], "go_terms": [], "name": "Pox_vCCI-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036541": {"description": "Phospholipase A1 superfamily", "go_ids": ["GO:0006629", "GO:0004620", "GO:0016020"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0004620:glycerophospholipase activity:F", "GO:0016020:membrane:C"], "name": "PLipase_A1_sf", "pathway_ids": ["PWY-8411", "PWY-8051", "PWY-7783", "PWY-7416", "PWY-8398", "PWY-7417", "PWY-8400", "PWY-8399", "PWY-7409", "PWY-6803", "PWY-8395", "PWY-8356", "PWY-8357", "PWY-8355", "PWY-8396", "PWY-8413", "PWY-8397", "PWY-8053", "PWY-8412", "PWY-8410"], "pathways": ["PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-8051:t:anandamide biosynthesis I", "PWY-7783:t:plasmalogen degradation", "PWY-7416:t:phospholipid remodeling (phosphatidylcholine, yeast)", "PWY-8398:t:alpha-linolenate metabolites biosynthesis", "PWY-7417:t:phospholipid remodeling (phosphatidate, yeast)", "PWY-8400:t:docosahexaenoate metabolites biosynthesis", "PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-7409:t:phospholipid remodeling (phosphatidylethanolamine, yeast)", "PWY-6803:t:phosphatidylcholine acyl editing", "PWY-8395:t:linoleate metabolites biosynthesis", "PWY-8356:t:maresin biosynthesis", "PWY-8357:t:protectin biosynthesis", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-8413:t:representative whole plasma EPA-derived icosanoids", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-8412:t:representative whole plasma DHA-derived icosanoids", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I"], "type": "Homologous_superfamily"}, "IPR036542": {"description": "Phosphotransferase system, lactose/cellobiose-type IIA subunit superfamily", "go_ids": ["GO:0009401"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PTS_IIA_lac/cel_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036543": {"description": "Guanylate-binding protein, C-terminal domain superfamily", "go_ids": ["GO:0005525", "GO:0003924"], "go_terms": ["GO:0005525:GTP binding:F", "GO:0003924:GTPase activity:F"], "name": "Guanylate-bd_C_sf", "pathway_ids": ["R-RNO-9953170", "R-HSA-168276", "R-HSA-909733", "R-HSA-877300", "R-DRE-9953170", "R-DRE-9948001", "R-HSA-9918487", "R-DRE-9968551", "R-HSA-9953170", "R-HSA-9948001", "R-HSA-9968551", "R-MMU-9953170", "R-HSA-9956593"], "pathways": ["R-RNO-9953170:r:GBP-mediated host defense", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-DRE-9953170:r:GBP-mediated host defense", "R-DRE-9948001:r:CASP4 inflammasome assembly", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-DRE-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-9953170:r:GBP-mediated host defense", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-HSA-9968551:r:Regulation of GBP-mediated host defense", "R-MMU-9953170:r:GBP-mediated host defense", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense"], "type": "Homologous_superfamily"}, "IPR036544": {"description": "Cytochrome b-c1 complex subunit 7 superfamily", "go_ids": ["GO:0045275", "GO:0006122"], "go_terms": ["GO:0045275:respiratory chain complex III:C", "GO:0006122:mitochondrial 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inner membrane:C", "GO:0045277:respiratory chain complex IV:C"], "name": "Cyt_c_oxidase_su5A/6_sf", "pathway_ids": ["R-MMU-9837999", "R-CEL-9837999", "R-DME-9707564", "R-DME-9837999", "R-RNO-5628897", "R-RNO-9707564", "R-BTA-9864848", "R-RNO-9837999", "R-HSA-5628897", "R-BTA-5628897", "R-DME-611105", "R-RNO-611105", "R-HSA-9864848", "R-HSA-611105", "R-DME-9864848", "R-SPO-9837999", "R-BTA-9837999", "R-HSA-9707564", "R-SCE-9837999", "R-MMU-611105", "R-MMU-5628897", "R-MMU-9864848", "R-HSA-9837999", "R-DME-5628897", "R-CEL-9864848", "R-MMU-9707564", "R-BTA-611105", "R-BTA-9707564"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-DME-9864848:r:Complex IV assembly", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9864848:r:Complex IV assembly", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR036546": {"description": "Mediator complex subunit 15, KIX domain", "go_ids": [], "go_terms": [], "name": "MED15_KIX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR036548": {"description": "Cytochrome c oxidase, subunit 8 superfamily", "go_ids": ["GO:0045277", "GO:0006123"], "go_terms": ["GO:0045277:respiratory chain complex IV:C", "GO:0006123:mitochondrial electron transport, cytochrome c to oxygen:P"], "name": "Cyt_c_oxidase_su8_sf", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-HSA-9707564", "R-MMU-5628897", "R-MMU-611105", "R-RNO-5628897", "R-MMU-9864848", "R-RNO-9707564", "R-HSA-5628897", "R-MMU-9707564"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR036549": {"description": "Cytochrome c oxidase subunit 6B/Cytochrome c oxidase assembly factor 6-like superfamily", "go_ids": ["GO:0005739"], "go_terms": ["GO:0005739:mitochondrion:C"], "name": "CX6/COA6-like_sf", "pathway_ids": ["R-RNO-5628897", "R-RNO-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-BTA-5628897", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-HSA-1268020", "R-HSA-9707564", "R-MMU-5628897", "R-MMU-611105", "R-MMU-9864848", "R-MMU-9707564", "R-BTA-611105", "R-BTA-9707564"], "pathways": ["R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR036550": {"description": "Peridinin-chlorophyll A binding superfamily", "go_ids": ["GO:0030076"], "go_terms": ["GO:0030076:light-harvesting complex:C"], "name": "Peridinin-chlorophyll-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036551": {"description": "Flavin prenyltransferase-like", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Flavin_trans-like", "pathway_ids": ["R-MMU-196783", "R-SCE-196783", "R-HSA-196783", "R-SPO-499943", "R-DDI-196783"], "pathways": ["R-MMU-196783:r:Coenzyme A biosynthesis", "R-SCE-196783:r:Coenzyme A biosynthesis", "R-HSA-196783:r:Coenzyme A biosynthesis", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-196783:r:Coenzyme A biosynthesis"], "type": "Homologous_superfamily"}, "IPR036552": {"description": "Core-binding factor, beta subunit superfamily", "go_ids": [], "go_terms": [], "name": "CBF_bsu_sf", "pathway_ids": ["R-DME-8941858", "R-MMU-8941326", "R-DME-8939243", "R-CEL-8951936", "R-CEL-8877330", "R-HSA-8939256", "R-DME-8931987", "R-MMU-8941858", "R-HSA-8936459", "R-CEL-8936459", "R-DME-8939247", "R-MMU-8939246", "R-CEL-8941858", "R-HSA-8951911", "R-MMU-8939247", "R-MMU-8934593", "R-MMU-8939245", "R-DME-8939246", "R-MMU-8939236", "R-HSA-8939236", "R-HSA-8941333", "R-HSA-8877330", "R-HSA-8939245", "R-HSA-8878166", "R-HSA-9616222", "R-MMU-8877330", "R-HSA-8941326", "R-HSA-9018519", "R-HSA-8951936", "R-CEL-8934593", "R-DME-8939245", "R-MMU-8936459", "R-MMU-8931987", "R-DME-8877330", "R-HSA-8931987", "R-HSA-8939247", "R-MMU-8951936", "R-DME-8934593", "R-DME-9018519", "R-HSA-8941858", "R-HSA-8949275", "R-DME-8939236", "R-CEL-8941326", "R-MMU-8878166", "R-HSA-8934593", "R-MMU-8939243", "R-HSA-8941332", "R-MMU-9018519", "R-DME-8878166", "R-HSA-8939902", "R-CEL-8939247", "R-CEL-8878166", "R-CEL-8939245", "R-HSA-8939243", "R-HSA-8935964", "R-CEL-8939236", "R-DME-8936459", "R-CEL-8939246", "R-DME-8951936", "R-DME-8941326", "R-HSA-8939246", "R-HSA-8939242", "R-HSA-8940973", "R-HSA-8941284", "R-CEL-8939243"], "pathways": ["R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8941326:r:RUNX2 regulates bone development", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-CEL-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-DME-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DME-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-8951911:r:RUNX3 regulates RUNX1-mediated transcription", "R-MMU-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-DME-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8941333:r:RUNX2 regulates genes involved in differentiation of myeloid cells", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-CEL-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DME-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-DME-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-DME-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-8949275:r:RUNX3 Regulates Immune Response and Cell Migration", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8941326:r:RUNX2 regulates bone development", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DME-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-CEL-8878166:r:Transcriptional regulation by RUNX2", "R-CEL-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8935964:r:RUNX1 regulates expression of components of tight junctions", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-DME-8951936:r:RUNX3 regulates p14-ARF", "R-DME-8941326:r:RUNX2 regulates bone development", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Homologous_superfamily"}, "IPR036553": {"description": "RNA 3'-terminal phosphate cyclase, insert domain superfamily", "go_ids": [], "go_terms": [], "name": "RPTC_insert", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Homologous_superfamily"}, "IPR036554": {"description": "GHMP kinase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "GHMP_kinase_C_sf", "pathway_ids": ["R-SCE-9969896", "R-SCE-446199", "R-DDI-446199", "R-MMU-9969896", "R-BTA-446199", "R-HSA-446199", "R-HSA-6787639", "R-CFA-70370", "R-RNO-446199", "R-DRE-9969896", "R-HSA-5609976", "R-MMU-70370", "R-SPO-446199", "R-BTA-70370", "R-RNO-9969896", "R-HSA-70370", "R-BTA-9969896", "R-DDI-9969896", "R-DRE-446199", "R-MMU-6787639", "R-MMU-446199", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["R-SCE-9969896:r:Lanosterol biosynthesis", "R-SCE-446199:r:Synthesis of dolichyl-phosphate", "R-DDI-446199:r:Synthesis of dolichyl-phosphate", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-BTA-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-6787639:r:GDP-fucose biosynthesis", "R-CFA-70370:r:Galactose catabolism", "R-RNO-446199:r:Synthesis of dolichyl-phosphate", "R-DRE-9969896:r:Lanosterol biosynthesis", "R-HSA-5609976:r:Defective GALK1 causes GALCT2", "R-MMU-70370:r:Galactose catabolism", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-70370:r:Galactose catabolism", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-HSA-70370:r:Galactose catabolism", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-MMU-6787639:r:GDP-fucose biosynthesis", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Homologous_superfamily"}, "IPR036555": {"description": "NusA, N-terminal domain superfamily", "go_ids": ["GO:0031554", "GO:0003700"], "go_terms": ["GO:0031554:regulation of termination of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "NusA_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036556": {"description": "Protein-arginine deiminase, central domain superfamily", "go_ids": ["GO:0005509", "GO:0005737"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0005737:cytoplasm:C"], "name": "PAD_central_sf", "pathway_ids": ["R-MMU-3247509", "R-HSA-3247509", "PWY-4921", "R-MMU-6798695", "R-HSA-6798695", "R-RNO-3247509", "R-RNO-6798695"], "pathways": ["R-MMU-3247509:r:Chromatin modifying enzymes", "R-HSA-3247509:r:Chromatin modifying enzymes", "PWY-4921:t:protein citrullination", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036557": {"description": "Methanol dehydrogenase, beta subunit superfamily", "go_ids": ["GO:0015946", "GO:0004022"], "go_terms": ["GO:0015946:methanol oxidation:P", "GO:0004022:alcohol dehydrogenase (NAD+) activity:F"], "name": "Meth_DH_bsu_sf", "pathway_ids": ["PWY-6966"], "pathways": ["PWY-6966:t:methanol oxidation to formaldehyde I"], "type": "Homologous_superfamily"}, "IPR036558": {"description": "YqbG-like superfamily", "go_ids": [], "go_terms": [], "name": "YqbG-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036559": {"description": "Bacteriochlorophyll A superfamily", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "Chl_A_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036560": {"description": "Methylamine/Aralkylamine dehydrogenase light chain superfamily", "go_ids": ["GO:0009308", "GO:0016638", "GO:0042597"], "go_terms": ["GO:0009308:amine metabolic process:P", "GO:0016638:oxidoreductase activity, acting on the CH-NH2 group of donors:F", "GO:0042597:periplasmic space:C"], "name": "MADH/AADH_L_sf", "pathway_ids": ["PWY-6967"], "pathways": ["PWY-6967:t:methylamine degradation I"], "type": "Homologous_superfamily"}, "IPR036561": {"description": "Mitochondrial glycoprotein superfamily", "go_ids": [], "go_terms": [], "name": "MAM33_sf", "pathway_ids": ["R-CEL-8980692", "R-BTA-140837", "R-MMU-9013106", "R-MMU-8980692", "R-HSA-140837", "R-RNO-8980692", "R-MMU-140837", "R-HSA-9013106", "R-HSA-111471", "R-SCE-9013106", "R-RNO-140837", "R-SPO-9013106", "R-SPO-8980692", "R-HSA-8980692", "R-SCE-8980692", "R-HSA-9645722", "R-BTA-8980692", "R-RNO-9013106", "R-BTA-9013106"], "pathways": ["R-CEL-8980692:r:RHOA GTPase cycle", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-111471:r:Apoptotic factor-mediated response", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-SPO-9013106:r:RHOC GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-9645722:r:Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function", "R-BTA-8980692:r:RHOA GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-BTA-9013106:r:RHOC GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036562": {"description": "Baculovirus p35 superfamily", "go_ids": ["GO:0043066"], "go_terms": ["GO:0043066:negative regulation of apoptotic process:P"], "name": "Baculovirus_p35_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036563": {"description": "Molybdopterin biosynthesis MoaE subunit superfamily", "go_ids": ["GO:0006777"], "go_terms": ["GO:0006777:Mo-molybdopterin cofactor biosynthetic process:P"], "name": "MoaE_sf", "pathway_ids": ["PWY-7887", "PWY-6823", "R-HSA-947581"], "pathways": ["PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6823:t:molybdopterin biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis"], "type": "Homologous_superfamily"}, "IPR036564": {"description": "AF0941-like superfamily", "go_ids": [], "go_terms": [], "name": "AF0941-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036565": {"description": "Mur-like, catalytic domain superfamily", "go_ids": ["GO:0009058", "GO:0005524"], "go_terms": ["GO:0009058:biosynthetic process:P", "GO:0005524:ATP binding:F"], "name": "Mur-like_cat_sf", "pathway_ids": ["R-SCE-196757", "R-SPO-196757", "R-DDI-196757", "R-MMU-196757", "R-HSA-196757", "R-CEL-196757"], "pathways": ["R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-DDI-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Homologous_superfamily"}, "IPR036566": {"description": "Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamily", "go_ids": ["GO:0006213", "GO:0016763"], "go_terms": ["GO:0006213:pyrimidine nucleoside metabolic process:P", "GO:0016763:pentosyltransferase activity:F"], "name": "PYNP-like_C_sf", "pathway_ids": ["PWY-7181", "R-RNO-73621", "R-MMU-73614", "R-HSA-73621", "R-HSA-73614", "R-MMU-73621", "R-RNO-73614"], "pathways": ["PWY-7181:t:pyrimidine deoxyribonucleosides degradation", "R-RNO-73621:r:Pyrimidine catabolism", "R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73621:r:Pyrimidine catabolism", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-73614:r:Pyrimidine salvage"], "type": "Homologous_superfamily"}, "IPR036567": {"description": "Ribosome hibernation promotion factor-like", "go_ids": [], "go_terms": [], "name": "RHF-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036568": {"description": "Gamma-glutamyl cyclotransferase-like superfamily", "go_ids": [], "go_terms": [], "name": "GGCT-like_sf", "pathway_ids": ["R-HSA-9648895", "R-RNO-174403", "R-BTA-174403", "R-MMU-174403", "R-SPO-174403", "R-HSA-174403", "R-DRE-174403"], "pathways": ["R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-DRE-174403:r:Glutathione synthesis and recycling"], "type": "Homologous_superfamily"}, "IPR036569": {"description": "Sugar-phosphate isomerase, RpiB/LacA/LacB superfamily", "go_ids": ["GO:0005975", "GO:0016853"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0016853:isomerase activity:F"], "name": "RpiB_LacA_LacB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036570": {"description": "HORMA domain superfamily", "go_ids": [], "go_terms": [], "name": "HORMA_dom_sf", "pathway_ids": ["R-SPO-141430", "R-RNO-110312", "R-HSA-2467813", "R-DDI-110312", "R-SPO-5656121", "R-SPO-5655862", "R-MMU-2467813", "R-CEL-1632852", "R-DRE-5656121", "R-MMU-1632852", "R-RNO-5655862", "R-MMU-179409", "R-MMU-110312", "R-SPO-110312", "R-DME-5656121", "R-MMU-68877", "R-HSA-174184", "R-GGA-5655862", "R-HSA-5655862", "R-DDI-179409", "R-DDI-141405", "R-XTR-110312", "R-HSA-141430", "R-DDI-176409", "R-HSA-68877", "R-DME-5655862", "R-DME-110312", "R-DRE-1632852", "R-MMU-141405", "R-GGA-353473", "R-HSA-5656121", "R-GGA-353299", "R-MMU-9648025", "R-HSA-141405", "R-MMU-5655862", "R-HSA-176409", "R-MMU-2500257", "R-MMU-176409", "R-RNO-5656121", "R-HSA-2500257", "R-MMU-141444", "R-GGA-5656121", "R-SCE-141430", "R-XTR-5656121", "R-DRE-5655862", "R-HSA-141444", "R-HSA-9648025", "R-SPO-141405", "R-SPO-179409", "R-HSA-110312", "R-BTA-1632852", "R-SCE-1632852", "R-GGA-110312", "R-SCE-141405", "R-MMU-5656121", "R-MMU-174184", "R-DDI-174184", "R-MMU-141430", "R-DDI-141430", "R-HSA-1632852", "R-DME-1632852", "R-HSA-5663220", "R-HSA-179409", "R-SCE-110312", "R-SPO-1632852", "R-MMU-5663220"], "pathways": ["R-SPO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-110312:r:Translesion synthesis by REV1", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DDI-110312:r:Translesion synthesis by REV1", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-1632852:r:Macroautophagy", "R-DRE-5656121:r:Translesion synthesis by POLI", "R-MMU-1632852:r:Macroautophagy", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-DME-5656121:r:Translesion synthesis by POLI", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-XTR-110312:r:Translesion synthesis by REV1", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-68877:r:Mitotic Prometaphase", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-110312:r:Translesion synthesis by REV1", "R-DRE-1632852:r:Macroautophagy", "R-MMU-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-GGA-353473:r:Translesion synthesis by Pol zeta", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-353299:r:RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-SCE-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-XTR-5656121:r:Translesion synthesis by POLI", "R-DRE-5655862:r:Translesion synthesis by POLK", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SPO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", 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GTPases Activate Formins"], "type": "Homologous_superfamily"}, "IPR036571": {"description": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase superfamily", "go_ids": ["GO:0016114", "GO:0008685"], "go_terms": ["GO:0016114:terpenoid biosynthetic process:P", "GO:0008685:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity:F"], "name": "MECDP_synthase_sf", "pathway_ids": ["PWY-7560"], "pathways": ["PWY-7560:t:methylerythritol phosphate pathway II"], "type": "Homologous_superfamily"}, "IPR036572": {"description": "Doublecortin domain superfamily", "go_ids": ["GO:0035556"], "go_terms": ["GO:0035556:intracellular signal transduction:P"], "name": "Doublecortin_dom_sf", "pathway_ids": ["R-HSA-447043", "R-DME-111932", "R-DME-442729", "R-DME-9648025"], "pathways": ["R-HSA-447043:r:Neurofascin interactions", "R-DME-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-DME-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-DME-9648025:r:EML4 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cell cycle genes", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-SSC-8941326:r:RUNX2 regulates bone development"], "type": "Homologous_superfamily"}, "IPR036579": {"description": "Photosystem I, reaction centre subunit PsaD superfamily", "go_ids": ["GO:0015979", "GO:0009538", "GO:0009522"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0009538:photosystem I reaction center:C", "GO:0009522:photosystem I:C"], "name": "PsaD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036580": {"description": "Phosphatase 2C, C-terminal domain superfamily", "go_ids": ["GO:0000287", "GO:0004721", "GO:0030145"], "go_terms": ["GO:0000287:magnesium ion binding:F", "GO:0004721:phosphoprotein phosphatase activity:F", "GO:0030145:manganese ion binding:F"], "name": "PP2C_C_sf", "pathway_ids": ["R-MMU-2173795", "R-RNO-2173795", "R-HSA-9700645", "R-MMU-380972", "R-RNO-380972", "R-HSA-2173795", 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LKB1-AMPK"], "type": "Homologous_superfamily"}, "IPR036581": {"description": "Cyanate lyase, C-terminal domain superfamily", "go_ids": ["GO:0009440"], "go_terms": ["GO:0009440:cyanate catabolic process:P"], "name": "Cyanate_lyase_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036582": {"description": "Copper amine oxidase-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Mao_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036583": {"description": "23S rRNA-intervening sequence superfamily", "go_ids": [], "go_terms": [], "name": "23S_rRNA_IVS_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036584": {"description": "Flagellar protein FliS superfamily", "go_ids": ["GO:0044780"], "go_terms": ["GO:0044780:bacterial-type flagellum assembly:P"], "name": "FliS_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036585": {"description": "Attractin superfamily", "go_ids": ["GO:0019953", "GO:0000772", "GO:0005576"], "go_terms": ["GO:0019953:sexual reproduction:P", "GO:0000772:mating pheromone activity:F", "GO:0005576:extracellular region:C"], "name": "Attractin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036586": {"description": "Neurotoxin B-IV-like superfamily", "go_ids": ["GO:0019871", "GO:0005576"], "go_terms": ["GO:0019871:sodium channel inhibitor activity:F", "GO:0005576:extracellular region:C"], "name": "Neurotoxin_B-IV-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036587": {"description": "Nuclease A inhibitor-like superfamily", "go_ids": [], "go_terms": [], "name": "NucleaseA_inhib-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036588": {"description": "Precorrin-8X methylmutase CobH/CbiC superfamily", "go_ids": ["GO:0009236", "GO:0016993"], "go_terms": ["GO:0009236:cobalamin biosynthetic process:P", "GO:0016993:precorrin-8X methylmutase activity:F"], "name": "CobH/CbiC_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036589": {"description": "Homocysteine-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "HCY_dom_sf", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-HSA-6798163", "R-MMU-9013407", "R-RNO-6798163", "R-CEL-9759218", "R-RNO-9759218", "R-MMU-6798163", "R-DRE-1614635", "R-RNO-9013407", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-DDI-1614635", "R-MMU-9759218", "R-MMU-1614635", "R-DRE-6798163", "R-HSA-156581", "R-HSA-9759218", "R-HSA-3359467", "R-RNO-156581", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-HSA-6798163:r:Choline catabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-6798163:r:Choline catabolism", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-6798163:r:Choline catabolism", "R-DRE-1614635:r:Sulfur amino acid metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-DRE-6798163:r:Choline catabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-RNO-156581:r:Methylation", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036590": {"description": "SOS response associated peptidase-like", "go_ids": [], "go_terms": [], "name": "SRAP-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036591": {"description": "YggU-like superfamily", "go_ids": [], "go_terms": [], "name": "YggU-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036592": {"description": "Photosystem I PsaL, reaction centre subunit XI superfamily", "go_ids": ["GO:0015979", "GO:0009538", "GO:0009522"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0009538:photosystem I reaction center:C", "GO:0009522:photosystem I:C"], "name": "PSI_PsaL_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036593": {"description": "CPE0013-like superfamily", "go_ids": [], "go_terms": [], "name": "CPE0013-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036594": {"description": "Methionine synthase domain", "go_ids": [], "go_terms": [], "name": "Meth_synthase_dom", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-MMU-9013407", "R-CEL-9759218", "R-RNO-9759218", "R-RNO-9013407", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-DDI-1614635", "R-MMU-9759218", "R-MMU-1614635", "R-HSA-156581", "R-HSA-9759218", "R-RNO-156581", "R-HSA-3359467", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-156581:r:Methylation", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036595": {"description": "Alpha-macroglobulin, receptor-binding domain superfamily", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "A-macroglobulin_rcpt-bd_sf", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-MMU-163125", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-163125", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036596": {"description": "Bacterial aa3 type cytochrome c oxidase subunit IV superfamily", "go_ids": [], "go_terms": [], "name": "Cyt-C_aa3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036597": {"description": "Fido-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Fido-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036598": {"description": "GOLD domain superfamily", "go_ids": [], "go_terms": [], "name": "GOLD_dom_sf", "pathway_ids": ["R-SPO-6807878", "R-HSA-1912420", "R-MMU-204005", "R-HSA-432722", "R-RNO-5694530", "R-RNO-6811434", "R-CEL-5694530", "R-SCE-6811434", "R-SCE-6807878", "R-RNO-6807878", "R-MMU-3238698", "R-MMU-5694530", "R-MMU-432722", "R-HSA-6807878", "R-HSA-3238698", "R-CEL-6807878", "R-RNO-3238698", "R-MMU-6807878", "R-DDI-6811434", "R-HSA-5694530", "R-RNO-204005", "R-HSA-204005", "R-BTA-3238698", "R-MMU-1912420", "R-HSA-6811434", "R-SPO-192105", "R-DDI-6807878", "R-SPO-6811434", "R-CEL-204005", "R-RNO-1912420", "R-SCE-192105", "R-CEL-6811434", "R-RNO-432722", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-5694530:r:Cargo concentration in the ER", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-5694530:r:Cargo concentration in the ER", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-5694530:r:Cargo concentration in the ER", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-RNO-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-BTA-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-192105:r:Synthesis of bile acids and bile salts", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-SCE-192105:r:Synthesis of bile acids and bile salts", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR036599": {"description": "DNA ligase, ATP-dependent, N-terminal domain superfamily", "go_ids": ["GO:0006281", "GO:0006310", "GO:0003677", "GO:0003910"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0003677:DNA binding:F", "GO:0003910:DNA ligase (ATP) activity:F"], "name": "DNA_ligase_N_sf", "pathway_ids": ["R-HSA-9825895", "R-MMU-5649702", "R-HSA-174414", "R-HSA-9913635", "R-DDI-5693571", "R-HSA-5696397", "R-HSA-5358606", "R-SCE-5358606", "R-SCE-110362", "R-MMU-110381", "R-RNO-110362", "R-HSA-5649702", "R-DDI-110381", "R-DME-5358565", "R-RNO-69183", "R-MMU-110362", "R-MMU-174414", "R-CEL-69183", "R-SCE-5358565", "R-DME-69183", "R-HSA-6782210", "R-MMU-5685939", "R-CEL-5358565", "R-MMU-5358606", "R-MMU-5358565", "R-DDI-5358565", "R-RNO-6782210", "R-DDI-5358606", "R-DDI-110362", "R-RNO-5358606", "R-RNO-5358565", "R-DME-5651801", "R-SCE-69183", "R-GGA-353423", "R-SPO-5358565", "R-MMU-5651801", "R-DDI-69183", "R-SPO-69183", "R-HSA-110362", "R-DME-5358606", "R-CEL-6782210", "R-HSA-5651801", "R-CEL-5358606", "R-HSA-5685939", "R-MMU-69183", "R-DDI-5649702", "R-HSA-164843", "R-HSA-162594", "R-HSA-5693571", "R-HSA-110381", "R-SPO-6782210", "R-HSA-69183", "R-RNO-5651801", "R-SPO-5358606", "R-HSA-5358565", "R-MMU-6782210", "R-CEL-5651801", "R-DME-6782210", "R-MMU-5693571", "R-RNO-174414", "R-SPO-5651801"], "pathways": ["R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SCE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DDI-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-CEL-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-CEL-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-DDI-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Homologous_superfamily"}, "IPR036600": {"description": "Paired amphipathic helix superfamily", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "PAH_sf", "pathway_ids": ["R-HSA-9022702", "R-MMU-8936459", "R-MMU-9824594", "R-HSA-9824594", "R-HSA-9022692", "R-MMU-3899300", "R-HSA-8936459", "R-HSA-427413", "R-HSA-983231", "R-CEL-9825892", "R-HSA-9022538", "R-CEL-9824594", "R-HSA-9615017", "R-MMU-9022692", "R-HSA-9707564", "R-HSA-400206", "R-HSA-9022699", "R-HSA-3899300", "R-MMU-9825892", "R-HSA-9825892", "R-HSA-9701898", "R-MMU-400206", "R-MMU-9707564"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9022538:r:Loss of MECP2 binding ability to 5mC-DNA", "R-CEL-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR036601": {"description": "CBM10 superfamily", "go_ids": ["GO:0005975", "GO:0030248"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0030248:cellulose binding:F"], "name": "CBM10_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036602": {"description": "tRNA wybutosine-synthesizing-like superfamily", "go_ids": [], "go_terms": [], "name": "tRNA_yW-synthesising-like_sf", "pathway_ids": ["PWY-7286", "R-HSA-6782861"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)"], "type": "Homologous_superfamily"}, "IPR036603": {"description": "RNA polymerase, RBP11-like subunit", "go_ids": ["GO:0006351", "GO:0046983"], "go_terms": ["GO:0006351:DNA-templated transcription:P", "GO:0046983:protein dimerization activity:F"], "name": "RBP11-like", "pathway_ids": ["R-CEL-73779", 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Clearance", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-PFA-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-PFA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-PFA-6782135:r:Dual incision in TC-NER", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-PFA-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing", "R-PFA-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Homologous_superfamily"}, "IPR036604": {"description": "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily", "go_ids": [], "go_terms": [], "name": "PurS-like_sf", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-MMU-73817", "R-CEL-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis"], "type": "Homologous_superfamily"}, "IPR036605": {"description": "Mago nashi superfamily", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "Mago_nashi_sf", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-HSA-73856", "R-DME-159236", "R-DME-72163", "R-RNO-72163", "R-SPO-975957", "R-CEL-73856", "R-HSA-72187", "R-DDI-72163", "R-RNO-73856", "R-DRE-159236", "R-DRE-72163", "R-DRE-73856", "R-RNO-159236", "R-DME-73856", "R-CEL-72163", "R-BTA-72163", "R-RNO-975957", "R-SPO-159236", "R-MMU-72163", "R-MMU-975957", "R-MMU-73856", "R-BTA-73856", "R-DRE-975957", "R-MMU-159236", "R-HSA-72163", "R-HSA-975957", "R-MMU-72187", "R-BTA-159236", "R-HSA-159236", "R-DDI-975957", "R-SPO-72163", "R-DME-975957", "R-CEL-159236"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Homologous_superfamily"}, "IPR036606": {"description": "EhaM-like superfamily", "go_ids": [], "go_terms": [], "name": "EhaM-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036607": {"description": "Glucosidase 2 subunit beta-like", "go_ids": [], "go_terms": [], "name": "PRKCSH", "pathway_ids": ["R-BTA-8957275", "R-HSA-532668", "R-HSA-9683686", "R-HSA-879415", "R-MMU-381426", "R-HSA-9694548", "R-MMU-9768727", "R-SCE-8856825", "R-BTA-381426", "R-SCE-6798695", "R-BTA-9768727", "R-HSA-8957275", "R-HSA-9768727", "R-HSA-901042", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9694548:r:Maturation of spike protein", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR036608": {"description": "MTH777-like superfamily", "go_ids": [], "go_terms": [], "name": "MTH777-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036609": {"description": "LCCL domain superfamily", "go_ids": [], "go_terms": [], "name": "LCCL_sf", "pathway_ids": ["R-MMU-6798695", "R-BTA-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036610": {"description": "PEBP-like superfamily", "go_ids": [], "go_terms": [], "name": "PEBP-like_sf", "pathway_ids": ["R-DME-5674135", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-RNO-5389840", "R-CEL-5675221", "R-HSA-6802952", "R-MMU-9937383", "R-HSA-5419276", "R-HSA-9937383", "R-RNO-5675221", "R-CEL-5674135", "R-BTA-9937383", "R-MMU-5389840", "R-CFA-5675221", "R-DME-5675221", "R-BTA-5675221", "R-BTA-5674135", "R-BTA-5389840", "R-RNO-5419276", "R-HSA-6802946", "R-HSA-9649948", "R-CFA-5674135", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-RNO-5674135", "R-RNO-9937383", "R-HSA-5389840", "R-HSA-6802955", "R-MMU-5675221", "R-HSA-5675221"], "pathways": ["R-DME-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-CFA-5675221:r:Negative regulation of MAPK pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CFA-5674135:r:MAP2K and MAPK activation", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Homologous_superfamily"}, "IPR036611": {"description": "Trigger factor ribosome-binding domain superfamily", "go_ids": ["GO:0015031", "GO:0006457"], "go_terms": ["GO:0015031:protein transport:P", "GO:0006457:protein folding:P"], "name": "Trigger_fac_ribosome-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036612": {"description": "K Homology domain, type 1 superfamily", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "KH_dom_type_1_sf", "pathway_ids": ["R-CEL-983231", "R-MMU-8849468", "R-MMU-72203", "R-RNO-8849468", "R-HSA-6802952", "R-MMU-9770562", "R-BTA-450385", "R-CEL-450385", "R-CEL-72203", "R-MMU-4570464", "R-SPO-72163", "R-DME-6791226", "R-HSA-9918487", "R-RNO-72163", "R-SPO-9930044", "R-HSA-9617828", "R-DME-9930044", "R-SCE-450385", "R-SCE-429958", "R-HSA-380994", "R-SCE-6791226", "R-RNO-983231", "R-CEL-429958", "R-CEL-9770562", "R-HSA-4570464", "R-CEL-6791226", "R-HSA-429958", "R-MMU-8964011", "R-HSA-5601884", "R-BTA-72163", "R-HSA-9610379", "R-MMU-9930044", "R-MMU-6791226", "R-DDI-429958", "R-BTA-6791226", "R-RNO-72203", "R-BTA-450513", "R-MMU-72163", "R-CEL-450604", "R-HSA-983231", "R-CEL-450513", "R-RNO-8964011", "R-BTA-9930044", "R-RNO-6791226", "R-SPO-9770562", "R-HSA-72163", "R-HSA-6791226", "R-RNO-4570464", "R-MMU-450604", "R-HSA-450604", "R-BTA-9770562", "R-CEL-9930044", "R-DDI-9930044", "R-HSA-8964011", "R-BTA-450604", "R-MMU-450385", "R-HSA-428359", "R-HSA-9930044", "R-DDI-6791226", "R-MMU-429958", "R-XTR-8849468", "R-BTA-4570464", "R-HSA-936440", "R-MMU-983231", "R-CEL-983168", "R-HSA-8849468", "R-HSA-6790901", "R-RNO-450604", "R-HSA-112126", "R-HSA-9836573", "R-CEL-72163", "R-SPO-429958", "R-HSA-9918481", "R-SPO-72203", "R-SCE-72203", "R-BTA-429958", "R-HSA-72203", "R-HSA-9770562", "R-SCE-450513", "R-DME-450385", "R-HSA-69895", "R-HSA-983168", "R-HSA-450385", "R-HSA-8949215", "R-MMU-450513", "R-HSA-5687128", "R-DME-429958", "R-DDI-450385", "R-DME-450513", "R-HSA-9692916", "R-HSA-450513", "R-RNO-9770562", "R-MMU-983168", "R-DRE-6791226", "R-DRE-8849468", "R-MMU-9758274", "R-DDI-450513", "R-BTA-72203", "R-SPO-6791226", "R-DRE-9758274", "R-CEL-8951664", "R-HSA-6804116"], "pathways": ["R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-BTA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-DME-9930044:r:Nuclear RNA decay", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-8964011:r:HDL clearance", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-8964011:r:HDL clearance", "R-BTA-9930044:r:Nuclear RNA decay", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-BTA-9770562:r:mRNA Polyadenylation", "R-CEL-9930044:r:Nuclear RNA decay", "R-DDI-9930044:r:Nuclear RNA decay", "R-HSA-8964011:r:HDL clearance", "R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-428359:r:Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-XTR-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-BTA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DME-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-DDI-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9758274:r:Regulation of NF-kappa B signaling", "R-CEL-8951664:r:Neddylation", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "type": "Homologous_superfamily"}, "IPR036613": {"description": "MHC class II-associated invariant chain, trimerisation domain superfamily", "go_ids": ["GO:0070206", "GO:0042289", "GO:0016020"], "go_terms": ["GO:0070206:protein trimerization:P", "GO:0042289:MHC class II protein binding:F", "GO:0016020:membrane:C"], "name": "MHCII_invariant_trimer_sf", "pathway_ids": ["R-HSA-9925563", "R-RNO-2132295", "R-HSA-2132295", "R-RNO-202733", "R-MMU-202733", "R-MMU-2132295", "R-HSA-202733"], "pathways": ["R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Homologous_superfamily"}, "IPR036614": {"description": "Holliday junction resolvase RusA-like superfamily", "go_ids": ["GO:0006281", "GO:0006310", "GO:0000287"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0006310:DNA recombination:P", "GO:0000287:magnesium ion binding:F"], "name": "RusA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036615": {"description": "Mur ligase, C-terminal domain superfamily", "go_ids": ["GO:0016881", "GO:0009058"], "go_terms": ["GO:0016881:acid-amino acid ligase activity:F", "GO:0009058:biosynthetic process:P"], "name": "Mur_ligase_C_dom_sf", "pathway_ids": ["R-SCE-196757", "R-SPO-196757", "R-DDI-196757", "R-MMU-196757", "R-HSA-196757", "R-CEL-196757"], "pathways": ["R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-DDI-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Homologous_superfamily"}, "IPR036616": {"description": "Poly(ADP-ribose) polymerase, regulatory domain superfamily", "go_ids": ["GO:0003950"], "go_terms": ["GO:0003950:NAD+ poly-ADP-ribosyltransferase activity:F"], "name": "Poly(ADP-ribose)pol_reg_dom_sf", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-MMU-2173795", "R-HSA-3108214", "R-HSA-192814", "R-DRE-5696400", "R-RNO-5685939", "R-RNO-110362", "R-RNO-3108214", "R-DRE-5685939", "R-DRE-110362", "R-DME-5696394", "R-DRE-5696395", "R-DRE-3108214", "R-MMU-5696395", "R-RNO-2173795", "R-MMU-110362", "R-HSA-2173795", "R-MMU-5685939", "R-MMU-5696394", "R-CEL-5696394", "R-MMU-5696400", "R-HSA-9683610", "R-RNO-5696395", "R-HSA-110362", "R-HSA-196807", "R-DME-5696395", "R-HSA-5685939", "R-DRE-5696394", "R-RNO-5696394", "R-HSA-9694631", "R-DME-5696400", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-5696394", "R-RNO-5696400", "R-HSA-5696400", "R-MMU-3108214"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-192814:r:vRNA Synthesis", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-196807:r:Nicotinate metabolism", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-DME-5696400:r:Dual Incision in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Homologous_superfamily"}, "IPR036617": {"description": "Barrier-to-autointegration factor, BAF superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "BAF_sf", "pathway_ids": ["R-HSA-180910", "R-HSA-162592", "R-HSA-2980766", "R-BTA-2995383", "R-HSA-177539", "R-MMU-2980766", "R-RNO-2995383", "R-DME-2995383", "R-BTA-2980766", "R-CEL-2995383", "R-HSA-175567", "R-DRE-2995383", "R-HSA-2995383", "R-RNO-2980766", "R-MMU-2995383", "R-HSA-180689", "R-HSA-164843"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-BTA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-MMU-2980766:r:Nuclear Envelope Breakdown", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-2980766:r:Nuclear Envelope Breakdown", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-DRE-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-2980766:r:Nuclear Envelope Breakdown", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation"], "type": "Homologous_superfamily"}, "IPR036618": {"description": "PtsI, HPr-binding domain superfamily", "go_ids": ["GO:0009401"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P"], "name": "PtsI_HPr-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036619": {"description": "NinB superfamily", "go_ids": [], "go_terms": [], "name": "NinB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036620": {"description": "Chromosomal protein MC1 superfamily", "go_ids": ["GO:0042262"], "go_terms": ["GO:0042262:DNA protection:P"], "name": "MC1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036621": {"description": "Anticodon-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Anticodon-bd_dom_sf", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-HSA-2408522", "R-HSA-2151201", "R-HSA-6782315", "R-MMU-9913635", "R-DME-9856649", "R-DME-9913635", "R-HSA-9856649", "R-HSA-379716", "R-BTA-9913635", "R-SCE-72203", "R-HSA-9633012", "R-HSA-9913635"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-BTA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR036622": {"description": "Dioxygenase LigAB, LigA subunit superfamily", "go_ids": [], "go_terms": [], "name": "LigA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036623": {"description": "Hemimethylated DNA-binding domain superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Hemimethylated_DNA-bd_sf", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Homologous_superfamily"}, "IPR036624": {"description": "Hcp1-like superfamily", "go_ids": [], "go_terms": [], "name": "Hcp1-lik_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036625": {"description": "E3-binding domain superfamily", "go_ids": ["GO:0016746"], "go_terms": ["GO:0016746:acyltransferase activity:F"], "name": "E3-bd_dom_sf", "pathway_ids": ["R-MMU-9837999", "R-SPO-9861559", "R-BTA-5362517", "R-RNO-9857492", "R-DDI-9857492", "R-CEL-9013407", "R-MMU-9861559", "R-BTA-204174", "R-MMU-70895", "R-BTA-9859138", "R-BTA-9837999", "R-HSA-1222541", "R-HSA-9837999", "R-HSA-9912481", "R-CEL-9859138", "R-HSA-5362517", "R-SPO-204174", "R-HSA-9859138", "R-RNO-9861559", "R-BTA-9013407", "R-BTA-70895", "R-MMU-9013407", "R-HSA-204174", "R-SPO-5362517", "R-CEL-9837999", "R-RNO-204174", "R-MMU-9857492", "R-BTA-9861559", "R-HSA-9865125", "R-SCE-9857492", "R-BTA-9857492", "R-HSA-9907570", "R-HSA-70895", "R-HSA-9861559", "R-HSA-9857492", "R-SPO-9857492", "R-CEL-9857492", "R-MMU-204174", "R-SCE-9861559", "R-MMU-9859138", "R-MMU-5362517", "R-HSA-9865113", "R-HSA-9912529", "R-DDI-9861559", "R-HSA-9013407", "R-RNO-5362517"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-5362517:r:Signaling by Retinoic Acid", "R-RNO-9857492:r:Protein lipoylation", "R-DDI-9857492:r:Protein lipoylation", "R-CEL-9013407:r:RHOH GTPase cycle", "R-MMU-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-BTA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-1222541:r:Cell redox homeostasis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-CEL-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-RNO-9861559:r:PDH complex synthesizes acetyl-CoA from PYR", "R-BTA-9013407:r:RHOH GTPase cycle", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-9857492:r:Protein 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Initiation", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER"], "type": "Homologous_superfamily"}, "IPR036644": {"description": "Ferredoxin thioredoxin reductase catalytic beta subunit superfamily", "go_ids": ["GO:0016730"], "go_terms": ["GO:0016730:oxidoreductase activity, acting on iron-sulfur proteins as donors:F"], "name": "FTR_bsu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036645": {"description": "Elafin-like superfamily", "go_ids": [], "go_terms": [], "name": "Elafin-like_sf", "pathway_ids": ["R-HSA-6798695", "R-RNO-6803157", "R-HSA-6809371", "R-SSC-6803157", "R-SSC-6809371", "R-HSA-6803157", "R-HSA-5654726", "R-HSA-9830364", "R-GGA-190373", "R-MMU-6798695", "R-HSA-190373", "R-MMU-6803157", "R-GGA-5654726", "R-HSA-9927418", "R-HSA-9927426"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6803157:r:Antimicrobial peptides", "R-HSA-6809371:r:Formation of the cornified envelope", "R-SSC-6803157:r:Antimicrobial peptides", "R-SSC-6809371:r:Formation of the cornified envelope", "R-HSA-6803157:r:Antimicrobial peptides", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-GGA-190373:r:FGFR1c ligand binding and activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-MMU-6803157:r:Antimicrobial peptides", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Homologous_superfamily"}, "IPR036646": {"description": "BPG-independent phosphoglycerate mutase, domain B superfamily", "go_ids": ["GO:0004619", "GO:0005737"], "go_terms": ["GO:0004619:phosphoglycerate mutase activity:F", "GO:0005737:cytoplasm:C"], "name": "PGAM_B_sf", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-2221", "PWY-7124", "PWY-6886", "PWY-6142", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901", "PWY-5484", "PWY-8362"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-8362:t:photorespiration II"], "type": "Homologous_superfamily"}, "IPR036647": {"description": "GTF2I-like repeat superfamily", "go_ids": [], "go_terms": [], "name": "GTF2I-like_rpt_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036648": {"description": "Nitrile hydratase alpha /Thiocyanate hydrolase gamma superfamily", "go_ids": ["GO:0003824", "GO:0046914"], "go_terms": ["GO:0003824:catalytic activity:F", "GO:0046914:transition metal ion binding:F"], "name": "CN_Hdrase_a/SCN_Hdrase_g_sf", "pathway_ids": ["PWY-5025", "PWY-581", "PWY-7308"], "pathways": ["PWY-5025:t:indole-3-acetate biosynthesis IV (bacteria)", "PWY-581:t:indole-3-acetate biosynthesis II", "PWY-7308:t:acrylonitrile degradation I"], "type": "Homologous_superfamily"}, "IPR036649": {"description": "Inorganic pyrophosphatase superfamily", "go_ids": ["GO:0006796", "GO:0000287", "GO:0004427", "GO:0005737"], "go_terms": ["GO:0006796:phosphate-containing compound metabolic process:P", "GO:0000287:magnesium ion binding:F", "GO:0004427:inorganic diphosphate phosphatase activity:F", "GO:0005737:cytoplasm:C"], "name": "Pyrophosphatase_sf", "pathway_ids": ["PWY-7807", "PWY-7805", "R-DME-379716", "R-HSA-379726", "R-SPO-379716", "R-PFA-379726", "R-PFA-379716", "R-CEL-379726", "R-HSA-71737", "R-SCE-71737", "R-DDI-71737", "R-MMU-379726", "R-HSA-379716", "R-SPO-379726", "R-CEL-71737", "R-PFA-71737", "R-DDI-379716", "R-DME-379726", "R-MMU-71737", "R-DDI-379726", "R-SCE-379726", "R-BTA-379716", "R-DME-71737", "R-BTA-71737", "R-MMU-379716", "R-CEL-379716", "R-SCE-379716", "R-SPO-71737"], "pathways": ["PWY-7807:t:glyphosate degradation III", "PWY-7805:t:(aminomethyl)phosphonate degradation", "R-DME-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-SPO-379716:r:Cytosolic tRNA aminoacylation", "R-PFA-379726:r:Mitochondrial tRNA aminoacylation", "R-PFA-379716:r:Cytosolic tRNA aminoacylation", "R-CEL-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-71737:r:Pyrophosphate hydrolysis", "R-SCE-71737:r:Pyrophosphate hydrolysis", "R-DDI-71737:r:Pyrophosphate hydrolysis", "R-MMU-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-SPO-379726:r:Mitochondrial tRNA aminoacylation", "R-CEL-71737:r:Pyrophosphate hydrolysis", "R-PFA-71737:r:Pyrophosphate hydrolysis", "R-DDI-379716:r:Cytosolic tRNA aminoacylation", "R-DME-379726:r:Mitochondrial tRNA aminoacylation", "R-MMU-71737:r:Pyrophosphate hydrolysis", "R-DDI-379726:r:Mitochondrial tRNA aminoacylation", "R-SCE-379726:r:Mitochondrial tRNA aminoacylation", "R-BTA-379716:r:Cytosolic tRNA aminoacylation", "R-DME-71737:r:Pyrophosphate hydrolysis", "R-BTA-71737:r:Pyrophosphate hydrolysis", "R-MMU-379716:r:Cytosolic tRNA aminoacylation", "R-CEL-379716:r:Cytosolic tRNA aminoacylation", "R-SCE-379716:r:Cytosolic tRNA aminoacylation", "R-SPO-71737:r:Pyrophosphate hydrolysis"], "type": "Homologous_superfamily"}, "IPR036650": {"description": "CAT RNA-binding domain superfamily", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "CAT_RNA-bd_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036651": {"description": "Glutamine synthetase, N-terminal domain superfamily", "go_ids": ["GO:1901704", "GO:0004356"], "go_terms": ["GO:1901704:L-glutamine biosynthetic process:P", "GO:0004356:glutamine synthetase activity:F"], "name": "Gln_synt_N_sf", "pathway_ids": ["PWY-6964", "PWY-8294", "PWY-8291", "PWY-6963", "R-SCE-210455", "R-BTA-8964539", "R-BTA-210455", "R-HSA-8964539", "R-DME-8964539", "R-RNO-8964539", "R-SPO-8964539", "R-CEL-210455", "R-MMU-8964539", "R-MMU-210455", "R-HSA-210455", "R-CEL-8964539", "R-SCE-8964539", "R-DME-210455", "R-SPO-210455", "R-RNO-210455"], "pathways": ["PWY-6964:t:ammonia assimilation cycle II", "PWY-8294:t:L-aspartate degradation III (anaerobic)", "PWY-8291:t:L-aspartate degradation II (aerobic)", "PWY-6963:t:ammonia assimilation cycle I", "R-SCE-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-BTA-8964539:r:Glutamate and glutamine metabolism", "R-BTA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-DME-8964539:r:Glutamate and glutamine metabolism", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-SPO-8964539:r:Glutamate and glutamine metabolism", "R-CEL-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-MMU-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-DME-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-SPO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-RNO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "type": "Homologous_superfamily"}, "IPR036652": {"description": "YjeF N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "YjeF_N_dom_sf", "pathway_ids": ["PWY-6938", "PWY-8137", "PWY-8136", "R-SPO-196807", "R-MMU-196807", "R-MMU-430039", "R-DME-196807", "R-DME-430039", "R-DRE-196807", "R-DRE-430039", "R-SCE-430039", "R-SCE-196807", "R-HSA-196807", "R-CEL-196807", "R-PFA-196807", "R-DDI-196807", "R-RNO-196807", "R-HSA-430039"], "pathways": ["PWY-6938:t:NADH repair (eukaryotes)", "PWY-8137:t:NADPH repair (eukaryotes)", "PWY-8136:t:NADPH repair (prokaryotes)", "R-SPO-196807:r:Nicotinate metabolism", "R-MMU-196807:r:Nicotinate metabolism", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DME-196807:r:Nicotinate metabolism", "R-DME-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DRE-196807:r:Nicotinate metabolism", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SCE-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-CEL-196807:r:Nicotinate metabolism", "R-PFA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Homologous_superfamily"}, "IPR036653": {"description": "CinA-like, C-terminal", "go_ids": [], "go_terms": [], "name": "CinA-like_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036654": {"description": "DNA polymerase III, psi subunit superfamily", "go_ids": ["GO:0008408", "GO:0006260", "GO:0003887"], "go_terms": ["GO:0008408:3'-5' exonuclease activity:F", "GO:0006260:DNA replication:P", "GO:0003887:DNA-directed DNA polymerase activity:F"], "name": "DNA_pol_III_psi_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036655": {"description": "Monomethylamine methyltransferase MtmB superfamily", "go_ids": ["GO:0032259", "GO:0008168"], "go_terms": ["GO:0032259:methylation:P", "GO:0008168:methyltransferase activity:F"], "name": "MtmB_sf", "pathway_ids": ["PWY-5247"], "pathways": ["PWY-5247:t:methanogenesis from methylamine"], "type": "Homologous_superfamily"}, "IPR036656": {"description": "Cytochrome b-c1 complex subunit 9 superfamily", "go_ids": ["GO:0045275", "GO:0006122"], "go_terms": ["GO:0045275:respiratory chain complex III:C", "GO:0006122:mitochondrial electron transport, ubiquinol to cytochrome c:P"], "name": "QCR9_sf", "pathway_ids": ["R-SCE-9865878", "R-HSA-611105", "R-HSA-9865881", "R-DDI-611105", "R-MMU-611105", "R-SPO-611105", "R-BTA-9865881", "R-SCE-611105", "R-DME-9865881", "R-DME-611105", "R-BTA-611105", "R-MMU-9865881"], "pathways": ["R-SCE-9865878:r:Complex III assembly", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-9865881:r:Complex III assembly", "R-DDI-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-BTA-9865881:r:Complex III assembly", "R-SCE-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR036657": {"description": "DNA-binding protein Tfx superfamily, archaea", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Tfx_DNA-bd_sf_arc", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036658": {"description": "CPI-17 superfamily", "go_ids": ["GO:0042325", "GO:0005737"], "go_terms": ["GO:0042325:regulation of phosphorylation:P", "GO:0005737:cytoplasm:C"], "name": "CPI-17_sf", "pathway_ids": ["R-RNO-5625740", "R-MMU-5625740", "R-HSA-5625740", "R-SSC-5625740"], "pathways": ["R-RNO-5625740:r:RHO GTPases activate PKNs", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-SSC-5625740:r:RHO GTPases activate PKNs"], "type": "Homologous_superfamily"}, "IPR036660": {"description": "Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain superfamily", "go_ids": ["GO:0016836"], "go_terms": ["GO:0016836:hydro-lyase activity:F"], "name": "Fe-S_hydroAse_TtdB_cat_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036661": {"description": "Luciferase-like domain superfamily", "go_ids": ["GO:0016705"], "go_terms": ["GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen:F"], "name": "Luciferase-like_sf", "pathway_ids": ["R-HSA-1222541"], "pathways": ["R-HSA-1222541:r:Cell redox homeostasis"], "type": "Homologous_superfamily"}, "IPR036662": {"description": "Phosphotransferase system, mannose-type IIA component superfamily", "go_ids": ["GO:0009401", "GO:0016020"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0016020:membrane:C"], "name": "PTS_EIIA_man-typ_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036663": {"description": "Fumarylacetoacetase-like, C-terminal domain superfamily", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Fumarylacetoacetase_C_sf", "pathway_ids": ["R-MMU-70268", "R-HSA-8963684", "R-CEL-70268", "R-RNO-70268", "R-DDI-70268", "R-RNO-8963684", "R-SPO-70268", "R-MMU-8963684", "R-CEL-8963684", "R-DDI-8963684", "R-HSA-70268", "R-BTA-70268", "R-SCE-70268"], "pathways": ["R-MMU-70268:r:Pyruvate metabolism", "R-HSA-8963684:r:Tyrosine catabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-RNO-70268:r:Pyruvate metabolism", "R-DDI-70268:r:Pyruvate metabolism", "R-RNO-8963684:r:Tyrosine catabolism", "R-SPO-70268:r:Pyruvate metabolism", "R-MMU-8963684:r:Tyrosine catabolism", "R-CEL-8963684:r:Tyrosine catabolism", "R-DDI-8963684:r:Tyrosine catabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Homologous_superfamily"}, "IPR036665": {"description": "Phosphotransferase system, glucitol/sorbitol-specific IIA component superfamily", "go_ids": ["GO:0009401", "GO:0008982", "GO:0005737"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F", "GO:0005737:cytoplasm:C"], "name": "PTS_IIA_glucitol/sorbitol_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036666": {"description": "HHA superfamily", "go_ids": [], "go_terms": [], "name": "HHA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036667": {"description": "Phosphotransferase system, sorbose subfamily IIB component superfamily", "go_ids": ["GO:0009401", "GO:0008982", "GO:0005737"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase 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Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-SSC-69481:r:G2/M Checkpoints", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DRE-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-RNO-6804754:r:Regulation of TP53 Expression", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-8941855:r:RUNX3 regulates CDKN1A transcription", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DRE-69473:r:G2/M DNA damage 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Genes", "R-DRE-9833482:r:PKR-mediated signaling", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-SSC-8941855:r:RUNX3 regulates CDKN1A transcription", "R-DRE-69481:r:G2/M Checkpoints", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DRE-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SSC-5689880:r:Ub-specific processing proteases", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-SSC-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-6804754:r:Regulation of TP53 Expression", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-DRE-5689880:r:Ub-specific processing proteases", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SSC-6804757:r:Regulation of TP53 Degradation", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-2028269:r:Signaling by Hippo", "R-SSC-69473:r:G2/M DNA damage checkpoint", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SSC-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-2028269:r:Signaling by Hippo", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-69541:r:Stabilization of p53", "R-HSA-2028269:r:Signaling by Hippo"], "type": "Homologous_superfamily"}, "IPR036676": {"description": "PurM-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PurM-like_C_sf", "pathway_ids": ["R-SSC-2408557", "R-SPO-73817", "R-HSA-2408557", "R-DDI-73817", "R-MMU-2408557", "R-DME-73817", "R-DRE-2408557", "R-DME-2408557", "R-DDI-2408557", "R-CEL-2408557", "R-SCE-73817", "R-BTA-73817", "R-CEL-73817", "R-HSA-73817", "R-MMU-73817", "R-GGA-419140"], "pathways": ["R-SSC-2408557:r:Selenocysteine synthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-2408557:r:Selenocysteine synthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-2408557:r:Selenocysteine synthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DRE-2408557:r:Selenocysteine synthesis", "R-DME-2408557:r:Selenocysteine synthesis", "R-DDI-2408557:r:Selenocysteine synthesis", "R-CEL-2408557:r:Selenocysteine synthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Homologous_superfamily"}, "IPR036677": {"description": "EutN/Ccml superfamily", "go_ids": [], "go_terms": [], "name": "EutN_CcmL_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036678": {"description": "MutS, connector domain superfamily", "go_ids": ["GO:0006298", "GO:0030983", "GO:0005524"], "go_terms": ["GO:0006298:mismatch repair:P", "GO:0030983:mismatched DNA binding:F", "GO:0005524:ATP binding:F"], "name": "MutS_con_dom_sf", "pathway_ids": ["R-BTA-5358606", "R-RNO-5358565", "R-SPO-5358565", "R-HSA-5632927", "R-HSA-5358606", "R-DDI-5358565", "R-SCE-5358606", "R-HSA-6796648", "R-DME-5358565", "R-HSA-5632928", "R-HSA-5632968", "R-BTA-5358565", "R-SCE-5358565", "R-HSA-912446", "R-SPO-5358606", "R-HSA-5358565", "R-MMU-5358606", "R-MMU-5358565"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "type": "Homologous_superfamily"}, "IPR036679": {"description": "FlgN-like superfamily", "go_ids": ["GO:0044780", "GO:0005515"], "go_terms": ["GO:0044780:bacterial-type flagellum assembly:P", "GO:0005515:protein binding:F"], "name": "FlgN-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036680": {"description": "Sporulation-like domain superfamily", "go_ids": ["GO:0042834"], "go_terms": ["GO:0042834:peptidoglycan binding:F"], "name": "SPOR-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036681": {"description": "PgpA-like superfamily", "go_ids": ["GO:0006629", "GO:0008962"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0008962:phosphatidylglycerophosphatase activity:F"], "name": "PgpA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036682": {"description": "4-Cysteine Soluble Protein superfamily", "go_ids": [], "go_terms": [], "name": "4CSP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036683": {"description": "CO dehydrogenase flavoprotein, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CO_DH_flav_C_dom_sf", "pathway_ids": ["R-MMU-9748787", "R-RNO-8851680", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", "R-RNO-74259", "R-GGA-421178", "R-DME-964975", "R-MMU-8851680", "R-HSA-9748787", "R-HSA-74259", "R-RNO-964975", "R-DME-74259", "R-MMU-964975", "R-DME-9748787", "R-MMU-74259", "R-DDI-964975", "R-RNO-9748787", "R-DDI-74259"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-GGA-421178:r:Urate synthesis", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-74259:r:Purine catabolism", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Homologous_superfamily"}, "IPR036684": {"description": "Calcium-mediated lectin superfamily", "go_ids": [], "go_terms": [], "name": "Ca_lectin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036685": {"description": "YehU-like superfamily", "go_ids": [], "go_terms": [], "name": "YehU-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036686": {"description": "Class II Hydrophobin superfamily", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Class_II_Hydrophobin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036687": {"description": "DinI-like superfamily", "go_ids": [], "go_terms": [], "name": "DinI-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036688": {"description": "MoeA, C-terminal, domain IV superfamily", "go_ids": ["GO:0032324"], "go_terms": ["GO:0032324:molybdopterin cofactor biosynthetic process:P"], "name": "MoeA_C_domain_IV_sf", "pathway_ids": ["PWY-8171", "R-DME-947581", "R-RNO-947581", "R-DDI-947581", "R-HSA-947581", "R-MMU-947581"], "pathways": ["PWY-8171:t:molybdenum cofactor biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Homologous_superfamily"}, "IPR036689": {"description": "ESAT-6-like superfamily", "go_ids": [], "go_terms": [], "name": "ESAT-6-like_sf", "pathway_ids": ["R-HSA-9636667", "R-HSA-9636383", "R-HSA-9635644", "R-HSA-9637628"], "pathways": ["R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-9635644:r:Inhibition of membrane repair", "R-HSA-9637628:r:Modulation by Mtb of host immune system"], "type": "Homologous_superfamily"}, "IPR036690": {"description": "Ferrodoxin-fold anticodon-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Fdx_antiC-bd_sf", "pathway_ids": ["R-HSA-379726"], "pathways": ["R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR036691": {"description": "Endonuclease/exonuclease/phosphatase superfamily", "go_ids": [], "go_terms": [], "name": "Endo/exonu/phosph_ase_sf", "pathway_ids": ["R-HSA-6798695", "R-RNO-9840310", "R-HSA-9013409", "R-MMU-8856828", "R-HSA-6804115", "R-HSA-110357", "R-HSA-5626978", "R-DRE-1855204", "R-RNO-9013409", "R-HSA-8856828", "R-CFA-1660499", "R-MMU-210990", "R-DRE-110373", "R-RNO-110362", "R-MMU-9013409", "R-SPO-1660499", "R-DRE-110362", "R-SPO-1855204", "R-HSA-1368108", "R-RNO-912526", "R-DRE-5693571", "R-RNO-210990", "R-SPO-1855183", "R-RNO-5626978", "R-HSA-73933", "R-RNO-202424", "R-MMU-1660514", "R-HSA-1855183", "R-MMU-110357", "R-RNO-432722", "R-RNO-5624958", "R-RNO-1855183", "R-MMU-73933", "R-CEL-1855204", "R-DME-5651801", "R-CFA-1855204", "R-DRE-110357", "R-RNO-8983711", "R-HSA-5624958", "R-MMU-5624958", "R-MMU-5651801", "R-HSA-429947", "R-HSA-110362", "R-DDI-73930", "R-CEL-1855183", "R-RNO-110357", "R-RNO-5693571", "R-DME-110373", "R-MMU-9013423", "R-MMU-110373", "R-MMU-912526", "R-RNO-73930", "R-MMU-73930", "R-HSA-1855204", "R-HSA-9820841", "R-DDI-110373", "R-MMU-6798695", "R-HSA-73930", "R-MMU-6804115", "R-MMU-5693571", "R-HSA-5617472", "R-HSA-9680350", "R-PFA-110357", "R-DRE-1660499", "R-RNO-6798695", "R-DDI-9840310", "R-MMU-9840310", "R-SCE-1855204", "R-MMU-432722", "R-DME-9840310", "R-DME-110357", "R-RNO-1660514", "R-HSA-1660499", "R-RNO-6804115", "R-HSA-9013423", "R-HSA-210990", "R-MMU-110362", "R-MMU-429947", "R-SPO-9013409", "R-RNO-8856828", "R-MMU-1855183", "R-RNO-73933", "R-MMU-5626978", "R-BTA-8983711", "R-MMU-1855204", "R-SCE-9840310", "R-HSA-432722", "R-HSA-9029569", "R-MMU-8983711", "R-MMU-202424", "R-CEL-8856828", "R-HSA-110373", "R-DDI-110362", "R-HSA-8983711", "R-HSA-9840310", "R-PFA-110373", "R-SPO-1660514", "R-SCE-1660499", "R-HSA-5651801", "R-HSA-1660514", "R-DDI-73933", "R-DRE-73933", "R-MMU-1660499", "R-RNO-9013423", "R-SCE-1855183", "R-HSA-193681", "R-HSA-5693571", "R-CFA-912526", "R-RNO-1660499", "R-CEL-9840310", "R-HSA-912526", "R-PFA-73933", "R-RNO-5651801", "R-HSA-202424", "R-RNO-1855204", "R-CEL-1660499", "R-DRE-5651801", "R-BTA-5693571", "R-DRE-73930", "R-SPO-9840310", "R-DME-73933", "R-DDI-110357", "R-RNO-110373", "R-DRE-6804115"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-210990:r:PECAM1 interactions", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-210990:r:PECAM1 interactions", "R-SPO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-HSA-73933:r:Resolution of Abasic Sites (AP sites)", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-73933:r:Resolution of Abasic Sites (AP sites)", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-CFA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-110357:r:Displacement of DNA glycosylase by APEX1", "R-RNO-8983711:r:OAS antiviral response", "R-HSA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-429947:r:Deadenylation of mRNA", 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multiple-nucleotide patch replacement pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-PFA-110357:r:Displacement of DNA glycosylase by APEX1", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-9840310:r:Glycosphingolipid catabolism", "R-DME-110357:r:Displacement of DNA glycosylase by APEX1", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-210990:r:PECAM1 interactions", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-429947:r:Deadenylation of mRNA", "R-SPO-9013409:r:RHOJ GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-73933:r:Resolution of Abasic Sites (AP sites)", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-BTA-8983711:r:OAS antiviral response", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-9840310:r:Glycosphingolipid catabolism", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-8983711:r:OAS antiviral response", "R-MMU-202424:r:Downstream TCR signaling", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DDI-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-PFA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-DDI-73933:r:Resolution of Abasic Sites (AP sites)", "R-DRE-73933:r:Resolution of Abasic Sites (AP sites)", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-SCE-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-193681:r:Ceramide signalling", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-CFA-912526:r:Interleukin receptor SHC signaling", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-9840310:r:Glycosphingolipid catabolism", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-PFA-73933:r:Resolution of Abasic Sites (AP sites)", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-SPO-9840310:r:Glycosphingolipid catabolism", "R-DME-73933:r:Resolution of Abasic Sites (AP sites)", "R-DDI-110357:r:Displacement of DNA glycosylase by APEX1", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Homologous_superfamily"}, "IPR036692": {"description": "Shew3726-like superfamily", "go_ids": [], "go_terms": [], "name": "Shew3726-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036693": {"description": "Transcription factor LuxR-like, autoinducer-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "TF_LuxR_autoind-bd_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036694": {"description": "Dodecin-like superfamily", "go_ids": [], "go_terms": [], "name": "Dodecin-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036695": {"description": "Arginyl tRNA synthetase N-terminal domain superfamily", "go_ids": ["GO:0006420", "GO:0004814", 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"R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Homologous_superfamily"}, "IPR036696": {"description": "YdfO-like superfamily", "go_ids": [], "go_terms": [], "name": "YdfO-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036697": {"description": "Hemocyanin, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Hemocyanin_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036698": {"description": "TM1070-like superfamily", "go_ids": [], "go_terms": [], "name": "TM1070-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036699": {"description": "YehR-like superfamily", "go_ids": [], "go_terms": [], "name": "YehR-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036700": {"description": "Bacterial OB-fold superfamily", "go_ids": [], "go_terms": [], "name": "BOBF_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036701": {"description": "RraB-like superfamily", "go_ids": [], "go_terms": [], "name": "RraB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036702": {"description": "ComB-like superfamily", "go_ids": ["GO:0050532", "GO:0000287"], "go_terms": ["GO:0050532:2-phosphosulfolactate phosphatase activity:F", "GO:0000287:magnesium ion binding:F"], "name": "ComB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036703": {"description": "MOB kinase activator superfamily", "go_ids": [], "go_terms": [], "name": "MOB_kinase_act_sf", "pathway_ids": ["R-DME-390150", "R-DME-390098", "R-MMU-2028269", "R-RNO-2028269", "R-DME-390089", "R-DME-2028269", "R-HSA-2028269", "R-DDI-2028269"], "pathways": ["R-DME-390150:r:DS ligand bound to FT receptor", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-MMU-2028269:r:Signaling by Hippo", 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{"description": "Vitelline membrane outer layer protein I (VOMI) superfamily", "go_ids": [], "go_terms": [], "name": "VOMI_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036707": {"description": "Cell division topological specificity factor MinE superfamily", "go_ids": ["GO:0051301", "GO:0032955"], "go_terms": ["GO:0051301:cell division:P", "GO:0032955:regulation of division septum assembly:P"], "name": "MinE_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036708": {"description": "BipD-like superfamily", "go_ids": [], "go_terms": [], "name": "BipD-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036709": {"description": "Autotransporter beta-domain superfamily", "go_ids": [], "go_terms": [], "name": "Autotransporte_beta_dom_sf", "pathway_ids": ["R-HSA-9760173", "R-HSA-9927020"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-9927020:r:Heme assimilation"], "type": 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expression", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with 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"R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-5578749:r:Transcriptional regulation by small RNAs", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-SPO-9770562:r:mRNA Polyadenylation", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Homologous_superfamily"}, "IPR036711": {"description": "VSV matrix superfamily", "go_ids": ["GO:0005198", "GO:0019031"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019031:viral envelope:C"], "name": "VSV_matrix_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036712": {"description": "Amb V Allergen superfamily", "go_ids": [], "go_terms": [], "name": "Amb_V_allergen_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036713": {"description": "TmoB-like superfamily", "go_ids": [], "go_terms": [], "name": "TmoB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036714": {"description": "Flavinator of succinate dehydrogenase superfamily", "go_ids": [], "go_terms": [], "name": "SDH_sf", "pathway_ids": ["R-DME-9854311", "R-RNO-9854311", "R-HSA-9854311", "R-BTA-9854311", "R-MMU-9854311", "R-CEL-9854311", "R-SPO-9854311", "R-DDI-9854311", "R-DRE-9854311", "R-SCE-9854311"], "pathways": ["R-DME-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Homologous_superfamily"}, "IPR036715": {"description": "Alpha-2,3-sialyltransferase superfamily", "go_ids": [], "go_terms": [], "name": "A-2_3-sialylTrfase_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036716": {"description": "Pesticidal crystal protein, N-terminal domain superfamily", "go_ids": ["GO:0090729"], "go_terms": ["GO:0090729:toxin activity:F"], "name": "Pest_crys_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036717": {"description": "GFRP superfamily", "go_ids": ["GO:0009890"], "go_terms": ["GO:0009890:negative regulation of biosynthetic process:P"], "name": "GFRP_sf", "pathway_ids": ["R-XTR-1474151", "R-BTA-1474151", "R-HSA-1474151", "R-DRE-1474151", "R-MMU-1474151", "R-RNO-1474151"], "pathways": ["R-XTR-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-BTA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DRE-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "type": "Homologous_superfamily"}, "IPR036718": {"description": "Quinohemoprotein amine dehydrogenase alpha subunit, domain 2 superfamily", "go_ids": [], "go_terms": [], "name": "H-AmDH_asu_dom2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036719": {"description": "Neurotransmitter-gated ion-channel transmembrane domain superfamily", "go_ids": ["GO:0006811", "GO:0016020"], "go_terms": ["GO:0006811:monoatomic ion transport:P", "GO:0016020:membrane:C"], "name": "Neuro-gated_channel_TM_sf", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-BTA-629597", "R-HSA-9667769", "R-DME-629594", "R-CEL-6798695", "R-HSA-977443", "R-GGA-977443", "R-BTA-112314", "R-DRE-629597", "R-BTA-629587", "R-CEL-112314", "R-HSA-629594", "R-RNO-112314", "R-RNO-629597", "R-MMU-112314", "R-MMU-629597", "R-DME-629587", "R-GGA-629587", "R-RNO-629594", "R-DRE-629594", "R-DME-6798695", "R-DME-977443", "R-RNO-629587", "R-GGA-629594", "R-DME-112314", "R-HSA-629587", "R-CEL-977443", "R-HSA-1236394", "R-CEL-629597", "R-GGA-629597", "R-BTA-977443", "R-CEL-629594", "R-DME-629597", "R-MMU-629587", "R-DRE-112314", "R-MMU-6798695", "R-MMU-977443", "R-BTA-629594", "R-HSA-112314", "R-CEL-629587", "R-MMU-629594", "R-HSA-629597", "R-RNO-977443"], "pathways": 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"R-CEL-977443:r:GABA receptor activation", "R-HSA-1236394:r:Signaling by ERBB4", "R-CEL-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-GGA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-977443:r:GABA receptor activation", "R-CEL-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-MMU-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-DRE-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-977443:r:GABA receptor activation", "R-BTA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-CEL-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-MMU-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-RNO-977443:r:GABA receptor activation"], "type": "Homologous_superfamily"}, "IPR036720": {"description": "Ran-GTPase activating protein 1, C-terminal domain superfamily", "go_ids": ["GO:0007165", "GO:0005096"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0005096:GTPase activator activity:F"], "name": "RanGAP1_C_sf", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-MMU-2467813", "R-HSA-141444", "R-MMU-68877", "R-HSA-9648025", "R-MMU-4615885", "R-MMU-9615933", "R-DME-9615933", "R-HSA-9615933", "R-HSA-68877", "R-HSA-165054", "R-HSA-9793242", "R-DME-4615885", "R-HSA-5663220", "R-HSA-4615885", "R-MMU-9648025", "R-MMU-9793242", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of 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mitotic spindle formation", "R-MMU-9793242:r:SUMOylation of nuclear envelope proteins", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Homologous_superfamily"}, "IPR036721": {"description": "Regulator of K+ conductance, C-terminal domain superfamily", "go_ids": ["GO:0006813"], "go_terms": ["GO:0006813:potassium ion transport:P"], "name": "RCK_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036722": {"description": "CART, C-terminal domain superfamily", "go_ids": ["GO:0043410", "GO:0007186", "GO:0008343", "GO:0032099", "GO:0005576", "GO:0005184"], "go_terms": ["GO:0043410:positive regulation of MAPK cascade:P", "GO:0007186:G protein-coupled receptor signaling pathway:P", "GO:0008343:adult feeding behavior:P", "GO:0032099:negative regulation of appetite:P", "GO:0005576:extracellular region:C", "GO:0005184:neuropeptide hormone activity:F"], "name": "CART_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036723": {"description": "Alpha-catenin/vinculin-like superfamily", "go_ids": ["GO:0007155", "GO:0051015"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0051015:actin filament binding:F"], "name": "Alpha-catenin/vinculin-like_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-5674135", "R-HSA-6802952", "R-CEL-6798695", "R-HSA-9766229", "R-MMU-445355", "R-DME-445355", "R-DDI-114608", "R-SSC-9764561", "R-HSA-418990", "R-SSC-9856530", "R-HSA-9764561", "R-DRE-5626467", "R-HSA-5218920", "R-HSA-9649948", "R-HSA-399955", "R-HSA-6802955", "R-CEL-525793", "R-XTR-525793", "R-GGA-445355", "R-HSA-6802948", "R-DRE-5218920", "R-MMU-399955", "R-CEL-9764561", "R-DME-114608", "R-DRE-9764561", "R-CEL-114608", "R-CEL-5674135", "R-GGA-6798695", "R-GGA-9764561", "R-GGA-5674135", "R-DME-5218920", "R-HSA-9762292", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-372708", "R-DME-9764561", "R-MMU-9766229", "R-MMU-354192", "R-RNO-6798695", "R-MMU-9860927", "R-HSA-9656223", "R-MMU-114608", "R-SSC-6798695", "R-MMU-5674135", "R-MMU-9856530", "R-HSA-5626467", "R-SSC-114608", "R-DME-525793", "R-RNO-114608", "R-RNO-9860927", "R-MMU-372708", "R-HSA-114608", "R-RNO-445355", "R-MMU-9764561", "R-HSA-6802946", "R-SSC-5674135", "R-RNO-5674135", "R-SSC-9860927", "R-HSA-525793", "R-HSA-354192", "R-HSA-381038", "R-RNO-9764561", "R-HSA-445355", "R-MMU-5626467", "R-MMU-5218920", "R-DME-6798695", "R-HSA-354194", "R-MMU-354194", "R-GGA-114608", "R-HSA-9764302", "R-MMU-418990", "R-RNO-9856530", "R-SSC-445355", "R-CEL-445355", "R-HSA-9833576", "R-MMU-525793", "R-HSA-9856530", "R-HSA-9725370", "R-DRE-525793", "R-CEL-5218920"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-SSC-9764561:r:Regulation of CDH1 Function", "R-HSA-418990:r:Adherens junctions interactions", "R-SSC-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9764561:r:Regulation of CDH1 Function", "R-DRE-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-CEL-525793:r:Myogenesis", "R-XTR-525793:r:Myogenesis", "R-GGA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DRE-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-DME-114608:r:Platelet degranulation", "R-DRE-9764561:r:Regulation of CDH1 Function", "R-CEL-114608:r:Platelet degranulation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-GGA-6798695:r:Neutrophil degranulation", "R-GGA-9764561:r:Regulation of CDH1 Function", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9762292:r:Regulation of CDH11 function", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-9764561:r:Regulation of CDH1 Function", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-114608:r:Platelet degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-SSC-114608:r:Platelet degranulation", "R-DME-525793:r:Myogenesis", "R-RNO-114608:r:Platelet degranulation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-RNO-445355:r:Smooth Muscle Contraction", "R-MMU-9764561:r:Regulation of CDH1 Function", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-525793:r:Myogenesis", "R-HSA-354192:r:Integrin signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-RNO-9764561:r:Regulation of CDH1 Function", "R-HSA-445355:r:Smooth Muscle Contraction", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-114608:r:Platelet degranulation", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-MMU-418990:r:Adherens junctions interactions", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SSC-445355:r:Smooth Muscle Contraction", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-9833576:r:CDH11 homotypic and heterotypic interactions", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DRE-525793:r:Myogenesis", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Homologous_superfamily"}, "IPR036724": {"description": "Cobalamin-binding domain superfamily", "go_ids": ["GO:0046872", "GO:0031419"], "go_terms": ["GO:0046872:metal ion binding:F", "GO:0031419:cobalamin binding:F"], "name": "Cobalamin-bd_sf", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-MMU-9013407", "R-CEL-71032", "R-CEL-9759218", "R-RNO-9759218", "R-RNO-9013407", "R-HSA-3359475", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-HSA-3359478", "R-DDI-1614635", "R-HSA-71032", "R-MMU-9759218", "R-MMU-1614635", "R-HSA-156581", "R-HSA-9759218", "R-MMU-71032", "R-HSA-3359467", "R-RNO-156581", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-3359475:r:Defective MMAA causes MMA, cblA type", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-3359478:r:Defective MUT causes MMAM", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-RNO-156581:r:Methylation", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036725": {"description": "Colicin E3-like ribonuclease domain superfamily", "go_ids": ["GO:0043022", "GO:0016788", "GO:0003723"], "go_terms": ["GO:0043022:ribosome binding:F", "GO:0016788:hydrolase activity, acting on ester bonds:F", "GO:0003723:RNA binding:F"], "name": "ColE3_ribonuclease_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036726": {"description": "GTP1/OBG domain superfamily", "go_ids": [], "go_terms": [], "name": "GTP1_OBG_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036727": {"description": "Olfactory marker superfamily", "go_ids": ["GO:0007165", "GO:0007608"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0007608:sensory perception of smell:P"], "name": "Olfactory_marker_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036728": {"description": "Pheromone/general odorant binding protein superfamily", "go_ids": ["GO:0005549"], "go_terms": ["GO:0005549:odorant binding:F"], "name": "PBP_GOBP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036729": {"description": "TRADD, N-terminal domain superfamily", "go_ids": ["GO:0060090", "GO:0043123", "GO:0005515"], "go_terms": ["GO:0060090:molecular adaptor activity:F", "GO:0043123:positive regulation of canonical NF-kappaB signal transduction:P", "GO:0005515:protein binding:F"], "name": "TRADD_N_sf", "pathway_ids": ["R-BTA-69416", "R-DRE-5675482", "R-MMU-5357786", "R-HSA-5218900", "R-BTA-5357905", "R-BTA-5218900", "R-DRE-75893", "R-DRE-5357956", "R-BTA-5357956", "R-BTA-5357786", "R-HSA-5675482", "R-MMU-5675482", "R-DRE-3371378", "R-HSA-75893", "R-MMU-5357956", "R-HSA-5357786", "R-HSA-69416", "R-DRE-5218900", "R-HSA-5213460", "R-MMU-69416", "R-DRE-5357905", "R-HSA-5357905", "R-BTA-75893", "R-HSA-5357956", "R-BTA-5675482", "R-HSA-9693928", "R-MMU-5357905", "R-MMU-3371378", "R-BTA-3371378", "R-MMU-5218900", "R-HSA-140534", "R-DRE-5357786", "R-HSA-3371378", "R-DRE-69416", "R-MMU-75893"], "pathways": ["R-BTA-69416:r:Dimerization of procaspase-8", "R-DRE-5675482:r:Regulation of necroptotic cell death", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-5218900:r:CASP8 activity is inhibited", "R-DRE-75893:r:TNF signaling", "R-DRE-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-3371378:r:Regulation by c-FLIP", "R-HSA-75893:r:TNF signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-69416:r:Dimerization of procaspase-8", "R-DRE-5218900:r:CASP8 activity is inhibited", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-69416:r:Dimerization of procaspase-8", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-75893:r:TNF signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-3371378:r:Regulation by c-FLIP", "R-BTA-3371378:r:Regulation by c-FLIP", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-DRE-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-3371378:r:Regulation by c-FLIP", "R-DRE-69416:r:Dimerization of procaspase-8", "R-MMU-75893:r:TNF signaling"], "type": "Homologous_superfamily"}, "IPR036730": {"description": "Phage P22 tailspike-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "P22_tailspike_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036731": {"description": "Baculovirus telokin-like protein 20 superfamily", "go_ids": [], "go_terms": [], "name": "Tlp20_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036732": {"description": "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "AFP_Neu5c_C_sf", "pathway_ids": ["R-MMU-4085001", "R-HSA-4085001", "R-DME-4085001"], "pathways": ["R-MMU-4085001:r:Sialic acid metabolism", "R-HSA-4085001:r:Sialic acid metabolism", "R-DME-4085001:r:Sialic acid metabolism"], "type": "Homologous_superfamily"}, "IPR036733": {"description": "B transposition protein, C-terminal domain superfamily", "go_ids": ["GO:0006313", "GO:0003677"], "go_terms": ["GO:0006313:DNA transposition:P", "GO:0003677:DNA binding:F"], "name": "B_transposit_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036734": {"description": "Neurotransmitter-gated ion-channel ligand-binding domain superfamily", "go_ids": ["GO:0006811", "GO:0005230", "GO:0016020"], "go_terms": ["GO:0006811:monoatomic ion transport:P", "GO:0005230:extracellular ligand-gated monoatomic ion channel activity:F", "GO:0016020:membrane:C"], "name": "Neur_chan_lig-bd_sf", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-BTA-629597", "R-HSA-9667769", "R-DME-629594", "R-CEL-6798695", "R-HSA-977443", "R-GGA-977443", "R-BTA-112314", "R-DRE-629597", "R-BTA-629587", "R-CEL-112314", "R-HSA-629594", "R-RNO-112314", "R-RNO-629597", "R-MMU-112314", "R-MMU-629597", "R-DME-629587", "R-GGA-629587", "R-RNO-629594", "R-DRE-629594", "R-DME-6798695", "R-DME-977443", "R-RNO-629587", "R-GGA-629594", "R-DME-112314", "R-HSA-629587", "R-CEL-977443", "R-HSA-1236394", "R-CEL-629597", "R-GGA-629597", "R-BTA-977443", "R-CEL-629594", "R-DME-629597", "R-MMU-629587", "R-DRE-112314", "R-MMU-6798695", "R-MMU-977443", "R-BTA-629594", "R-HSA-112314", "R-CEL-629587", "R-MMU-629594", "R-HSA-629597", "R-RNO-977443"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-DME-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977443:r:GABA receptor activation", "R-GGA-977443:r:GABA receptor activation", "R-BTA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-DRE-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-CEL-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-RNO-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-RNO-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-MMU-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-DME-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-GGA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-RNO-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DRE-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-977443:r:GABA receptor activation", "R-RNO-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-GGA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-CEL-977443:r:GABA receptor activation", "R-HSA-1236394:r:Signaling by ERBB4", "R-CEL-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-GGA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-977443:r:GABA receptor activation", "R-CEL-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-MMU-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-DRE-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-977443:r:GABA receptor activation", "R-BTA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-CEL-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-MMU-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-RNO-977443:r:GABA receptor activation"], "type": "Homologous_superfamily"}, "IPR036735": {"description": "NusG, N-terminal domain superfamily", "go_ids": ["GO:0006354"], "go_terms": ["GO:0006354:DNA-templated transcription elongation:P"], "name": "NGN_dom_sf", "pathway_ids": ["R-GGA-6796648", "R-SCE-6796648", "R-SPO-113418", "R-DME-113418", "R-SPO-77075", "R-CEL-75955", "R-MMU-6796648", "R-GGA-6807505", "R-DME-674695", "R-HSA-167243", "R-SCE-113418", "R-SCE-72086", "R-DRE-72086", "R-HSA-167242", "R-CEL-113418", "R-CEL-77075", "R-MMU-674695", "R-MMU-6807505", "R-CEL-674695", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-DRE-674695", "R-MMU-77075", "R-HSA-75955", "R-SCE-77075", "R-CEL-112382", "R-HSA-167160", "R-SCE-674695", "R-MMU-72086", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382", "R-SPO-674695", "R-HSA-6807505", "R-GGA-112382", "R-HSA-167238", "R-GGA-75955", "R-MMU-113418", "R-GGA-674695", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DME-77075", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-DRE-6807505", "R-DRE-77075", "R-HSA-167287", "R-DRE-75955", "R-HSA-167246", "R-DRE-6796648", "R-DME-72086", "R-DRE-113418", "R-HSA-167152", "R-HSA-113418", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086"], "pathways": ["R-GGA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-72086:r:mRNA Capping", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-GGA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-GGA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-72086:r:mRNA Capping", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping"], "type": "Homologous_superfamily"}, "IPR036736": {"description": "ACP-like superfamily", "go_ids": [], "go_terms": [], "name": "ACP-like_sf", "pathway_ids": ["R-HSA-9029558", "R-MMU-9937383", "R-DDI-75105", "R-HSA-6799198", "R-DME-6799198", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-DDI-9857492", "R-MMU-199220", "R-RNO-199220", "R-DME-9857492", "R-MMU-196757", "R-MMU-611105", "R-DDI-199220", "R-XTR-196757", "R-HSA-9918481", "R-HSA-77289", "R-HSA-163765", "R-MMU-9857492", "R-MMU-6799198", "R-DME-77289", "R-HSA-9937383", "R-SCE-9857492", "R-HSA-196757", "R-MMU-75105", "R-DDI-77289", "R-HSA-9857492", "R-SCE-77289", "R-DME-611105", "R-SPO-9857492", "R-HSA-611105", "R-HSA-75105", "R-MMU-77289", "R-RNO-196757", "R-SPO-77289", "R-HSA-2426168"], "pathways": ["R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DDI-9857492:r:Protein lipoylation", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DME-9857492:r:Protein lipoylation", "R-MMU-196757:r:Metabolism of folate and pterines", "R-MMU-611105:r:Respiratory electron transport", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-XTR-196757:r:Metabolism of folate and pterines", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-MMU-9857492:r:Protein lipoylation", "R-MMU-6799198:r:Complex I biogenesis", "R-DME-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-9857492:r:Protein lipoylation", "R-HSA-196757:r:Metabolism of folate and pterines", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-9857492:r:Protein lipoylation", "R-SCE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-611105:r:Respiratory electron transport", "R-SPO-9857492:r:Protein lipoylation", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-196757:r:Metabolism of folate and pterines", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Homologous_superfamily"}, "IPR036737": {"description": "OmpA-like domain superfamily", "go_ids": [], "go_terms": [], "name": "OmpA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036738": {"description": "FKBP12-rapamycin binding domain superfamily", "go_ids": ["GO:0044877"], "go_terms": ["GO:0044877:protein-containing complex binding:F"], "name": "FRB_sf", "pathway_ids": ["R-SPO-3371571", "R-MMU-1632852", "R-SPO-389357", "R-MMU-9639288", "R-SPO-9639288", "R-SCE-389357", "R-DME-380972", "R-HSA-9639288", "R-RNO-5218920", "R-DDI-6804757", "R-MMU-389357", "R-HSA-5218920", "R-RNO-1632852", "R-SCE-6804757", "R-CEL-1257604", "R-DME-3371571", "R-HSA-6804757", "R-HSA-8943724", "R-DDI-5218920", "R-CEL-9639288", "R-RNO-3371571", "R-CEL-165159", "R-MMU-5628897", "R-SCE-9856530", "R-RNO-389357", "R-RNO-165159", "R-HSA-5674400", "R-MMU-165159", "R-CEL-5628897", "R-RNO-5628897", "R-SPO-5218920", "R-DDI-380972", "R-DME-5218920", "R-RNO-6804757", "R-DDI-9856530", "R-RNO-380972", "R-DME-1257604", "R-HSA-1632852", "R-HSA-389357", "R-RNO-9639288", "R-DME-1632852", "R-DME-165159", "R-HSA-1257604", "R-DME-389357", "R-DME-8943724", "R-DME-5628897", "R-RNO-8943724", "R-MMU-9856530", "R-DDI-165159", "R-SCE-9639288", "R-MMU-380972", "R-CEL-1632852", "R-RNO-1257604", "R-CEL-3371571", "R-HSA-5628897", "R-RNO-166208", "R-HSA-166208", "R-CEL-8943724", "R-CEL-389357", "R-DME-166208", "R-SCE-1257604", "R-HSA-9920951", "R-SPO-6804757", "R-SPO-1257604", "R-SCE-3371571", "R-HSA-380972", "R-SPO-9856530", "R-DDI-9639288", "R-DDI-5628897", "R-DME-9639288", "R-DDI-1632852", "R-DDI-1257604", "R-MMU-5218920", "R-MMU-6804757", "R-DDI-166208", "R-MMU-3371571", "R-CEL-380972", "R-MMU-1257604", "R-DDI-3371571", "R-CEL-6804757", "R-MMU-8943724", "R-RNO-9856530", "R-DDI-8943724", "R-HSA-165159", "R-HSA-3371571", "R-DDI-389357", "R-MMU-166208", "R-HSA-9856530", "R-CEL-166208", "R-DME-9856530", "R-CEL-5218920", "R-SCE-5218920", "R-CEL-9856530"], "pathways": ["R-SPO-3371571:r:HSF1-dependent transactivation", "R-MMU-1632852:r:Macroautophagy", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-1632852:r:Macroautophagy", "R-SCE-6804757:r:Regulation of TP53 Degradation", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-CEL-165159:r:MTOR signalling", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-165159:r:MTOR signalling", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-165159:r:MTOR signalling", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-HSA-1632852:r:Macroautophagy", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-DME-1632852:r:Macroautophagy", "R-DME-165159:r:MTOR signalling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-165159:r:MTOR signalling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-1632852:r:Macroautophagy", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-166208:r:mTORC1-mediated signalling", "R-HSA-166208:r:mTORC1-mediated signalling", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-166208:r:mTORC1-mediated signalling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-DDI-1632852:r:Macroautophagy", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-HSA-165159:r:MTOR signalling", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-166208:r:mTORC1-mediated signalling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Homologous_superfamily"}, "IPR036739": {"description": "SLC41A/MgtE divalent cation transporters, integral membrane domain superfamily", "go_ids": ["GO:0006812", "GO:0008324"], "go_terms": ["GO:0006812:monoatomic cation transport:P", "GO:0008324:monoatomic cation transmembrane transporter activity:F"], "name": "SLC41_membr_dom_sf", "pathway_ids": ["R-HSA-425410", "R-MMU-425410", "R-GGA-425410", "R-DRE-425410"], "pathways": ["R-HSA-425410:r:Metal ion SLC transporters", "R-MMU-425410:r:Metal ion SLC transporters", "R-GGA-425410:r:Metal ion SLC transporters", "R-DRE-425410:r:Metal ion SLC transporters"], "type": "Homologous_superfamily"}, "IPR036740": {"description": "tRNA intron endonuclease, N-terminal domain superfamily", "go_ids": ["GO:0006388", "GO:0000213"], "go_terms": ["GO:0006388:tRNA splicing, via endonucleolytic cleavage and ligation:P", "GO:0000213:tRNA-intron lyase activity:F"], "name": "tRNA_intron_Endonuc_N_sf", "pathway_ids": ["PWY-7803", "PWY-6689"], "pathways": ["PWY-7803:t:tRNA splicing II", "PWY-6689:t:tRNA splicing I"], "type": "Homologous_superfamily"}, "IPR036741": {"description": "TAFII-230 TBP-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "TAFII-230_TBP-bd_sf", "pathway_ids": ["R-MMU-75953", "R-DME-674695", "R-DME-76042", "R-MMU-6804756", "R-DME-73779", "R-MMU-674695", "R-DME-6804756", "R-HSA-167162", "R-HSA-167161", "R-DME-73776", "R-HSA-73776", "R-HSA-6804756", "R-HSA-75953", "R-MMU-73776", "R-HSA-76042", "R-HSA-674695", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-HSA-73779"], "pathways": ["R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Homologous_superfamily"}, "IPR036742": {"description": "ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial", "go_ids": ["GO:0015986", "GO:0046933", "GO:0045259"], "go_terms": ["GO:0015986:proton motive force-driven ATP synthesis:P", "GO:0046933:proton-transporting ATP synthase activity, rotational mechanism:F", "GO:0045259:proton-transporting ATP synthase complex:C"], "name": "ATP_synth_F1_esu_sf_mt", "pathway_ids": ["R-BTA-8949613", "R-MMU-163210", "R-DME-8949613", "R-BTA-163210", "R-DME-163210", "R-RNO-163210", "R-RNO-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-BTA-8949613:r:Cristae formation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-8949613:r:Cristae formation", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Homologous_superfamily"}, "IPR036743": {"description": "Actin-related protein 2/3 complex subunit 5 superfamily", "go_ids": ["GO:0034314", "GO:0030833", "GO:0015629", "GO:0005885"], "go_terms": ["GO:0034314:Arp2/3 complex-mediated actin nucleation:P", "GO:0030833:regulation of actin filament polymerization:P", "GO:0015629:actin cytoskeleton:C", "GO:0005885:Arp2/3 protein complex:C"], "name": "ARPC5_sf", "pathway_ids": ["R-HSA-5663213", "R-HSA-6798695", "R-DDI-6798695", "R-DDI-2029482", "R-CEL-8856828", "R-SPO-2029482", "R-SPO-6798695", "R-MMU-8856828", "R-HSA-8856828", "R-CEL-6798695", "R-SCE-6798695", "R-DDI-5663213", "R-HSA-2029482", "R-CEL-5663213", "R-SPO-5663213", "R-HSA-3928662", "R-CEL-2029482", "R-RNO-2029482", "R-MMU-2029482", "R-RNO-5663213", "R-MMU-5663213", "R-SCE-5663213", "R-SCE-2029482", "R-RNO-3928662", "R-MMU-3928662", "R-MMU-6798695", "R-RNO-8856828", "R-CEL-3928662", "R-HSA-9664422", "R-RNO-6798695"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SPO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR036744": {"description": "RAP domain superfamily", "go_ids": [], "go_terms": [], "name": "RAP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036745": {"description": "DNA polymerase III-theta superfamily", "go_ids": ["GO:0006260", "GO:0003677", "GO:0003887"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0003677:DNA binding:F", "GO:0003887:DNA-directed DNA polymerase activity:F"], "name": "PolIII_theta_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036746": {"description": "TT1725-like superfamily", "go_ids": [], "go_terms": [], "name": "TT1725-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036747": {"description": "Histone chaperone ASF1-like superfamily", "go_ids": ["GO:0006325", "GO:0005634"], "go_terms": ["GO:0006325:chromatin organization:P", "GO:0005634:nucleus:C"], "name": "ASF1-like_sf", "pathway_ids": ["R-SCE-2559584", "R-BTA-2559584", "R-HSA-2559584", "R-GGA-2559584", "R-MMU-2559584", "R-CEL-2559584"], "pathways": ["R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-BTA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-GGA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Homologous_superfamily"}, "IPR036748": {"description": "MTH938-like superfamily", "go_ids": [], "go_terms": [], "name": "MTH938-like_sf", "pathway_ids": ["R-DME-6799198", "R-BTA-6799198", "R-HSA-6799198", "R-MMU-6799198", "R-RNO-6799198", "R-DRE-6799198", "R-XTR-6799198"], "pathways": ["R-DME-6799198:r:Complex I biogenesis", "R-BTA-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-6799198:r:Complex I biogenesis", "R-XTR-6799198:r:Complex I biogenesis"], "type": "Homologous_superfamily"}, "IPR036749": {"description": "Expansin, cellulose-binding-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Expansin_CBD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036751": {"description": "Stage V sporulation protein G superfamily", "go_ids": ["GO:0030435"], "go_terms": ["GO:0030435:sporulation resulting in formation of a cellular spore:P"], "name": "SpoVG_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036753": {"description": "Actin-related protein 2/3 complex subunit 3 superfamily", "go_ids": ["GO:0034314", "GO:0005856", "GO:0005885"], "go_terms": ["GO:0034314:Arp2/3 complex-mediated actin nucleation:P", "GO:0005856:cytoskeleton:C", "GO:0005885:Arp2/3 protein complex:C"], "name": "ARPC3_sf", "pathway_ids": ["R-HSA-5663213", "R-DDI-2029482", "R-BTA-8856828", "R-BTA-2029482", "R-MMU-8856828", "R-CEL-8856828", "R-SPO-2029482", "R-HSA-8856828", "R-BTA-3928662", "R-DDI-5663213", "R-HSA-2029482", "R-CEL-5663213", "R-MMU-2029482", "R-HSA-3928662", "R-SPO-5663213", "R-CEL-2029482", "R-MMU-5663213", "R-BTA-5663213", "R-SCE-5663213", "R-SCE-2029482", "R-MMU-3928662", "R-CEL-3928662", "R-HSA-9664422"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-SPO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis"], "type": "Homologous_superfamily"}, "IPR036754": {"description": "YbaK/aminoacyl-tRNA synthetase-associated domain superfamily", "go_ids": ["GO:0002161"], "go_terms": ["GO:0002161:aminoacyl-tRNA deacylase activity:F"], "name": "YbaK/aa-tRNA-synt-asso_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036755": {"description": "SRS domain superfamily", "go_ids": [], "go_terms": [], "name": "SRS_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036756": {"description": "H/ACA ribonucleoprotein complex, subunit Nop10 superfamily", "go_ids": ["GO:0042254", "GO:0001522", "GO:0030515"], "go_terms": ["GO:0042254:ribosome biogenesis:P", "GO:0001522:pseudouridine synthesis:P", "GO:0030515:snoRNA binding:F"], "name": "H/ACA_rnp_Nop10_sf", "pathway_ids": ["R-MMU-171319", "R-HSA-6790901", "R-HSA-171319", "R-DRE-171319"], "pathways": ["R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase"], "type": "Homologous_superfamily"}, "IPR036757": {"description": "Transferrin receptor-like, dimerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "TFR-like_dimer_dom_sf", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-MMU-8856828", "R-MMU-9013106", "R-HSA-8856828", "R-SSC-9013408", "R-MMU-9013408", "R-RNO-9013149", "R-SSC-9013026", "R-MMU-9013404", "R-SSC-917977", "R-SPO-9013106", "R-SSC-9013407", "R-SCE-8980692", "R-SPO-9696273", "R-RNO-9013408", "R-RNO-9013406", "R-HSA-9013408", "R-RNO-9013404", "R-SCE-9696273", "R-RNO-917977", "R-SSC-432722", "R-RNO-432722", "R-SCE-8963693", "R-MMU-9013407", "R-RNO-8963693", "R-HSA-8963693", "R-RNO-9013407", "R-SSC-9013406", "R-RNO-9696273", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-917977", "R-MMU-9013406", "R-SSC-9013149", "R-MMU-8963693", "R-HSA-9013026", "R-HSA-917977", "R-HSA-9013407", "R-SSC-9013148", "R-SSC-9696270", "R-HSA-9725554", "R-SSC-9013404", "R-MMU-8856825", "R-RNO-9696270", "R-MMU-8980692", "R-MMU-432722", "R-RNO-8980692", "R-HSA-9013106", "R-SSC-8980692", "R-SPO-9013406", "R-HSA-9013423", "R-SCE-9013406", "R-HSA-9013148", "R-SSC-8856825", "R-RNO-9013106", "R-RNO-8856828", "R-HSA-432722", "R-CEL-8963693", "R-SPO-8963693", "R-RNO-8856825", "R-HSA-9696270", "R-SSC-9696273", "R-SSC-9013423", "R-SCE-9013106", "R-RNO-9013423", "R-SSC-8856828", "R-HSA-8856825", "R-MMU-9013026", "R-SSC-9013106", "R-HSA-9013406", "R-MMU-9696270", "R-MMU-9696273", "R-MMU-9013149", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-9013408:r:RHOG GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-SSC-9013026:r:RHOB GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-SSC-917977:r:Transferrin endocytosis and recycling", "R-SPO-9013106:r:RHOC GTPase cycle", "R-SSC-9013407:r:RHOH GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-SCE-9696273:r:RND1 GTPase cycle", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SSC-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-SSC-9696270:r:RND2 GTPase cycle", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SSC-8980692:r:RHOA GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-SPO-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SSC-9696273:r:RND1 GTPase cycle", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036758": {"description": "At5g01610-like superfamily", "go_ids": [], "go_terms": [], "name": "At5g01610-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036759": {"description": "Thiamin pyrophosphokinase, catalytic domain superfamily", "go_ids": ["GO:0009229", "GO:0004788", "GO:0005524"], "go_terms": ["GO:0009229:thiamine diphosphate biosynthetic process:P", "GO:0004788:thiamine diphosphokinase activity:F", "GO:0005524:ATP binding:F"], "name": "TPK_catalytic_sf", "pathway_ids": ["PWY-6898", "PWY-6908", "PWY-6907", "PWY-7356", "R-HSA-196819", "R-BTA-196819", "R-SPO-196819", "R-SCE-196819", "R-CEL-196819", "R-MMU-196819"], "pathways": ["PWY-6898:t:thiamine diphosphate salvage III", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism", "R-SPO-196819:r:Vitamin B1 (thiamin) metabolism", "R-SCE-196819:r:Vitamin B1 (thiamin) metabolism", "R-CEL-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Homologous_superfamily"}, "IPR036760": {"description": "SspB-like superfamily", "go_ids": [], "go_terms": [], "name": "SspB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036761": {"description": "Lipid/polyisoprenoid-binding, YceI-like superfamily", "go_ids": [], "go_terms": [], "name": "TTHA0802/YceI-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036762": {"description": "IscX-like superfamily", "go_ids": [], "go_terms": [], "name": "IscX-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036763": {"description": "Putative dsDNA mimic superfamily", "go_ids": [], "go_terms": [], "name": "Put_dsDNA_mimic_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036764": {"description": "Cysteine protease Prp superfamily", "go_ids": [], "go_terms": [], "name": "Peptidase_Prp_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036765": {"description": "ZipA, C-terminal FtsZ-binding domain superfamily", "go_ids": ["GO:0090529"], "go_terms": ["GO:0090529:cell septum assembly:P"], "name": "ZipA_FtsZ-bd_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036766": {"description": "Fe(II) trafficking protein YggX superfamily", "go_ids": ["GO:0005506"], "go_terms": ["GO:0005506:iron ion binding:F"], "name": "Fe_traffick_prot_YggX_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036767": {"description": "ApaG domain superfamily", "go_ids": [], "go_terms": [], "name": "ApaG_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036768": {"description": "DNA polymerase III subunit chi superfamily", "go_ids": [], "go_terms": [], "name": "PolIII_chi_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036769": {"description": "Large ribosomal subunit protein uL11, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL11_C_sf", "pathway_ids": ["R-HSA-5419276", "R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-CFA-1799339", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9937383", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-RNO-5419276", "R-CFA-72706", "R-DDI-9954714", "R-HSA-5368286", "R-CEL-72706", "R-CFA-9954709", "R-RNO-9937383", "R-HSA-5389840", "R-CEL-9954716", "R-CEL-9954714", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", 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"R-DDI-9907900", "R-DDI-392517", "R-MMU-1169091", "R-HSA-2995383", "R-MMU-9017802", "R-HSA-350054", "R-MMU-447043", "R-MMU-5607761", "R-RNO-69231", "R-SSC-202424", "R-RNO-9856530", "R-DME-445989", "R-HSA-5693571", "R-HSA-9909649", "R-DME-214399", "R-HSA-9856530", "R-MMU-9013149", "R-HSA-5693579", "R-HSA-1912399", "R-MMU-2559585", "R-DME-9013420", "R-HSA-9927426", "R-BTA-983168", "R-RNO-5627123", "R-HSA-1989781", "R-MMU-446353", "R-BTA-69231", "R-HSA-139853", "R-MMU-204005", "R-MMU-8953750", "R-RNO-2995383", "R-MMU-5607764", "R-DME-209560", "R-DME-8951664", "R-DME-5621575", "R-DRE-8951664", "R-SSC-1810476", "R-RNO-9013149", "R-HSA-9818749", "R-MMU-5693616", "R-HSA-5676590", "R-HSA-9013424", "R-MMU-9013404", "R-RNO-448706", "R-DME-933542", "R-HSA-9927418", "R-HSA-5545619", "R-RNO-1482788", "R-HSA-9709570", "R-RNO-2029485", "R-RNO-5625740", "R-CEL-114508", "R-RNO-9013424", "R-HSA-4641257", "R-RNO-202424", "R-MMU-5628897", "R-MMU-5693568", "R-BTA-446343", "R-RNO-9013406", "R-SCE-192105", "R-HSA-9825892", "R-HSA-9018519", "R-HSA-5601884", "R-HSA-9663199", "R-DRE-170984", "R-MMU-5684264", "R-MMU-9907900", "R-RNO-8853659", "R-MMU-192105", "R-RNO-209560", "R-MMU-8853659", "R-MMU-5578775", "R-RNO-9013507", "R-RNO-9696273", "R-CEL-446353", "R-MMU-9604323", "R-MMU-6811436", "R-HSA-9013404", "R-RNO-9931295", "R-HSA-9013149", "R-HSA-1169091", "R-HSA-8980692", "R-MMU-2871837", "R-HSA-2644607", "R-HSA-9704331", "R-MMU-77289", "R-RNO-445989", "R-HSA-8948751", "R-HSA-418890", "R-SPO-71288", "R-HSA-5689603", "R-HSA-9860927", "R-HSA-5693554", "R-RNO-5693616", "R-RNO-983168", "R-HSA-193692", "R-HSA-445989", "R-MMU-69231", "R-HSA-8853884", "R-HSA-5689901", "R-BTA-8951664", "R-MMU-196807", "R-DME-1169091", "R-MMU-139853", "R-MMU-73762", "R-HSA-2122948", "R-RNO-9696270", "R-RNO-9017802", "R-DME-1810476", "R-HSA-2559585", "R-HSA-418889", "R-DDI-8849471", "R-HSA-2559582", "R-DME-9860927", "R-HSA-5628897", "R-HSA-1912408", "R-HSA-9017802", "R-SCE-8948751", "R-RNO-3295583", "R-DME-5620916", "R-HSA-448706", "R-HSA-3214841", "R-HSA-9954709", "R-BTA-139853", "R-DME-5607761", "R-SSC-5689880", "R-HSA-5578775", "R-DME-209394", "R-MMU-5689603", "R-HSA-9920951", "R-RNO-6804756", "R-MMU-446343", "R-RNO-170984", "R-HSA-9619229", "R-HSA-5607764", "R-HSA-2173796", "R-DDI-1169408", "R-HSA-9630794", "R-MMU-5357786", "R-HSA-9013508", "R-HSA-9013420", "R-MMU-8964539", "R-HSA-9662361", "R-MMU-6794361", "R-HSA-6807878", "R-RNO-5684264", "R-MMU-5685942", "R-MMU-983695", "R-RNO-4755510", "R-DDI-5621575", "R-HSA-1810476", "R-DDI-983168", "R-DDI-9909505", "R-CEL-3295583", "R-BTA-2151201", "R-HSA-6803204", "R-MMU-9013026", "R-MMU-8941856", "R-MMU-983168", "R-HSA-9022699", "R-DDI-168638", "R-MMU-9696270", "R-MMU-8857538", "R-MMU-3295583", "R-HSA-9696273", "R-HSA-5627117"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8951664:r:Neddylation", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-CEL-139853:r:Elevation of cytosolic Ca2+ levels", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-CFA-9013407:r:RHOH GTPase cycle", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-448706:r:Interleukin-1 processing", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-202424:r:Downstream TCR signaling", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9824272:r:Somitogenesis", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-9907900:r:Proteasome assembly", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-BTA-196807:r:Nicotinate metabolism", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-2672351:r:Stimuli-sensing channels", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-DDI-9833482:r:PKR-mediated signaling", "R-HSA-8983711:r:OAS antiviral response", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-DME-5578775:r:Ion homeostasis", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-9020702:r:Interleukin-1 signaling", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-DDI-8951664:r:Neddylation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DDI-170968:r:Frs2-mediated activation", "R-MMU-8951664:r:Neddylation", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9630791:r:Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-DRE-9696270:r:RND2 GTPase cycle", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9632697:r:Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-6794361:r:Neurexins and neuroligins", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-HSA-9632700:r:Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-XTR-9017802:r:Noncanonical activation of NOTCH3", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-HSA-844456:r:The NLRP3 inflammasome", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-9930044:r:Nuclear RNA decay", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DRE-9696273:r:RND1 GTPase cycle", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-SSC-4755510:r:SUMOylation of immune response proteins", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-RNO-5689603:r:UCH proteinases", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-9035034:r:RHOF GTPase 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response proteins", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-3295583:r:TRP channels", "R-BTA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-3295583:r:TRP channels", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Homologous_superfamily"}, "IPR036771": {"description": "F0F1 ATP synthase delta/epsilon subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "ATPsynth_dsu/esu_N", "pathway_ids": ["R-BTA-8949613", "R-CEL-163210", "R-MMU-163210", "R-BTA-163210", "R-CEL-8949613", "R-RNO-163210", "R-RNO-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210"], "pathways": ["R-BTA-8949613:r:Cristae formation", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Homologous_superfamily"}, "IPR036772": {"description": "SRCR-like domain superfamily", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "SRCR-like_dom_sf", "pathway_ids": ["R-BTA-2243919", "R-HSA-2243919", "R-DRE-114608", "R-HSA-3000480", "R-DRE-2243919", "R-RNO-2243919", "R-BTA-2168880", "R-HSA-9662834", "R-HSA-2168880", "R-HSA-1566948", "R-MMU-3000480", "R-MMU-2243919", "R-RNO-114608", "R-HSA-6806942", "R-RNO-977606", "R-HSA-5578768", "R-HSA-114608", "R-BTA-114608", "R-MMU-8852405", "R-HSA-3000471", "R-HSA-9678110", "R-HSA-977606", "R-RNO-8852405", "R-MMU-1566948", "R-MMU-2168880", "R-MMU-5683826", "R-RNO-6806942", "R-MMU-5578768", "R-HSA-8852405", "R-DRE-3000480", "R-BTA-1566948", "R-HSA-9733458", "R-MMU-977606", "R-MMU-3000471", "R-RNO-5578768", "R-HSA-9694614", "R-RNO-1566948", "R-RNO-5683826", "R-MMU-6806942", "R-HSA-5683826", "R-MMU-114608"], "pathways": ["R-BTA-2243919:r:Crosslinking of collagen fibrils", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-DRE-114608:r:Platelet degranulation", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-DRE-2243919:r:Crosslinking of collagen fibrils", "R-RNO-2243919:r:Crosslinking of collagen fibrils", "R-BTA-2168880:r:Scavenging of heme from plasma", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-1566948:r:Elastic fibre formation", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-RNO-114608:r:Platelet degranulation", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-977606:r:Regulation of Complement cascade", "R-HSA-5578768:r:Physiological factors", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-MMU-8852405:r:Signaling by MST1", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8852405:r:Signaling by MST1", "R-MMU-1566948:r:Elastic fibre formation", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-5683826:r:Surfactant metabolism", "R-RNO-6806942:r:MET Receptor Activation", "R-MMU-5578768:r:Physiological factors", "R-HSA-8852405:r:Signaling by MST1", "R-DRE-3000480:r:Scavenging by Class A Receptors", "R-BTA-1566948:r:Elastic fibre formation", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-MMU-977606:r:Regulation of Complement cascade", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-5578768:r:Physiological factors", "R-HSA-9694614:r:Attachment and Entry", "R-RNO-1566948:r:Elastic fibre formation", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-6806942:r:MET Receptor Activation", "R-HSA-5683826:r:Surfactant metabolism", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036773": {"description": "TGF-beta binding (TB) domain superfamily", "go_ids": [], "go_terms": [], "name": "TB_dom_sf", "pathway_ids": ["R-HSA-1474228", "R-SSC-2473224", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-216083", "R-BTA-1566948", "R-BTA-1474228", "R-BTA-201451", "R-HSA-1566948", "R-BTA-2173789", "R-BTA-2473224", "R-HSA-2473224", "R-MMU-8957275", "R-RNO-2129379", "R-BTA-8957275", "R-RNO-381426", "R-DRE-2473224", "R-RNO-2473224", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-MMU-216083", "R-HSA-8957275", "R-MMU-2473224", "R-MMU-1566948", "R-BTA-216083", "R-BTA-2129379", "R-RNO-2173789", "R-HSA-381426", "R-HSA-2173789", "R-MMU-2129379", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-SSC-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-BTA-1566948:r:Elastic fibre formation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-BTA-201451:r:Signaling by BMP", "R-HSA-1566948:r:Elastic fibre formation", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-2473224:r:Antagonism of Activin by Follistatin", "R-HSA-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-2473224:r:Antagonism of Activin by Follistatin", "R-RNO-2473224:r:Antagonism of Activin by Follistatin", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-2473224:r:Antagonism of Activin by Follistatin", "R-MMU-1566948:r:Elastic fibre formation", "R-BTA-216083:r:Integrin cell surface interactions", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Homologous_superfamily"}, "IPR036774": {"description": "ERV/ALR sulfhydryl oxidase domain superfamily", "go_ids": ["GO:0016972"], "go_terms": ["GO:0016972:thiol oxidase activity:F"], "name": "ERV/ALR_sulphydryl_oxid_sf", "pathway_ids": ["PWY-7533", "R-RNO-381426", "R-HSA-6798695", "R-HSA-114608", "R-RNO-8957275", "R-HSA-1268020", "R-MMU-381426", "R-MMU-6798695", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036775": {"description": "DNA polymerase, Y-family, little finger domain superfamily", "go_ids": ["GO:0006281", "GO:0003684"], "go_terms": ["GO:0006281:DNA repair:P", "GO:0003684:damaged DNA binding:F"], "name": "DNA_pol_Y-fam_lit_finger_sf", "pathway_ids": ["R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656121", "R-SPO-5656169", "R-SPO-5655862", "R-HSA-5696397", "R-MMU-110320", "R-MMU-110312", "R-SPO-110312", "R-DME-5656121", "R-GGA-5655862", "R-HSA-5655862", "R-GGA-353503", "R-DME-5655862", "R-DME-110312", "R-HSA-6782210", "R-HSA-5656169", "R-HSA-5656121", "R-MMU-5696400", "R-MMU-5655862", "R-GGA-5656121", "R-DME-110320", "R-CEL-5655862", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-CEL-6782210", "R-HSA-110312", "R-CEL-5696397", "R-GGA-110312", "R-GGA-5656169", "R-MMU-5656121", "R-SPO-5696400", "R-SPO-110320", "R-CEL-6782135", "R-HSA-5696400", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-HSA-110320"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-DME-5656121:r:Translesion synthesis by POLI", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-GGA-353503:r:Translesion synthesis by Pol kappa", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-DME-110320:r:Translesion Synthesis by POLH", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110312:r:Translesion synthesis by REV1", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-110320:r:Translesion Synthesis by POLH"], "type": "Homologous_superfamily"}, "IPR036777": {"description": "Nucleoside-specific channel-forming protein, Tsx-like superfamily", "go_ids": ["GO:0009279"], "go_terms": ["GO:0009279:cell outer membrane:C"], "name": "Channel_Tsx-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036778": {"description": "Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase superfamily", "go_ids": [], "go_terms": [], "name": "OHCU_decarboxylase_sf", "pathway_ids": ["PWY-5691", "PWY-7849", "PWY-7394"], "pathways": ["PWY-5691:t:urate conversion to allantoin I", "PWY-7849:t:urate conversion to allantoin III", "PWY-7394:t:urate conversion to allantoin II"], "type": "Homologous_superfamily"}, "IPR036779": {"description": "LysM domain superfamily", "go_ids": [], "go_terms": [], "name": "LysM_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036780": {"description": "PG1857-like superfamily", "go_ids": [], "go_terms": [], "name": "PG1857-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036781": {"description": "Smr-associated-like superfamily", "go_ids": [], "go_terms": [], "name": "Smr_assoc-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036782": {"description": "NE0471-like, N-terminal", "go_ids": [], "go_terms": [], "name": "NE0471-like_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036784": {"description": "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "AK/P_DHK_N_sf", "pathway_ids": ["R-DME-204174", "R-BTA-70895", "R-MMU-9837999", "R-HSA-204174", "R-SPO-5362517", "R-CEL-9837999", "R-RNO-204174", "R-DME-9837999", "R-CEL-5362517", "R-CEL-204174", "R-HSA-70895", "R-RNO-9837999", "R-HSA-9841922", "R-RNO-70895", "R-MMU-204174", "R-MMU-70895", "R-SPO-9837999", "R-MMU-5362517", "R-HSA-9912481", "R-HSA-9837999", "R-HSA-5362517", "R-DME-5362517", "R-SPO-204174", "R-RNO-5362517"], "pathways": ["R-DME-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-RNO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-DME-9837999:r:Mitochondrial protein degradation", "R-CEL-5362517:r:Signaling by Retinoic Acid", "R-CEL-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-MMU-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-DME-5362517:r:Signaling by Retinoic Acid", "R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-5362517:r:Signaling by Retinoic Acid"], "type": "Homologous_superfamily"}, "IPR036785": {"description": "YkyA-like superfamily", "go_ids": [], "go_terms": [], "name": "YkyA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036786": {"description": "Ribosome maturation protein SBDS, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosome_mat_SBDS_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036787": {"description": "Translation initiation factor 3 (IF-3), N-terminal domain superfamily", "go_ids": ["GO:0006413", "GO:0003743"], "go_terms": ["GO:0006413:translational initiation:P", "GO:0003743:translation initiation factor activity:F"], "name": "T_IF-3_N_sf", "pathway_ids": ["R-HSA-5368286"], "pathways": ["R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Homologous_superfamily"}, "IPR036788": {"description": "Translation initiation factor 3 (IF-3), C-terminal domain superfamily", "go_ids": ["GO:0006413"], "go_terms": ["GO:0006413:translational initiation:P"], "name": "T_IF-3_C_sf", "pathway_ids": ["R-HSA-5368286"], "pathways": ["R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Homologous_superfamily"}, "IPR036789": {"description": "Large ribosomal subunit protein uL6-like, alpha-beta domain superfamily", "go_ids": ["GO:0006412", "GO:0019843", "GO:0003735", "GO:0005840"], "go_terms": ["GO:0006412:translation:P", "GO:0019843:rRNA binding:F", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C"], "name": "Ribosomal_uL6-like_a/b-dom_sf", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954716", "R-CEL-9954714", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-SPO-9954709", "R-SPO-975956", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-CEL-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036790": {"description": "Frizzled cysteine-rich domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Frizzled_dom_sf", "pathway_ids": ["R-DRE-5140745", "R-RNO-5140745", "R-HSA-373080", "R-MMU-8856828", "R-MMU-5632684", "R-GGA-4608870", "R-MMU-4641263", "R-DME-216217", "R-HSA-3000178", "R-HSA-8856828", "R-DRE-4641263", "R-MMU-4086398", "R-MMU-5099900", "R-RNO-5635838", "R-RNO-5610787", "R-DME-4086400", "R-RNO-4641263", "R-DME-350376", "R-HSA-1650814", "R-DRE-5610787", "R-DRE-4641262", "R-DME-350411", "R-DME-4641262", "R-MMU-5610787", "R-HSA-8948216", "R-DME-209472", "R-CEL-4086398", "R-DME-5610787", "R-HSA-5140745", "R-DME-4608870", "R-MMU-5578768", "R-MMU-5635838", "R-MMU-1592389", "R-RNO-4086400", "R-DRE-5620922", "R-MMU-4086400", "R-DME-5140745", "R-RNO-5578768", "R-MMU-5140745", "R-HSA-4608870", "R-HSA-2022090", "R-HSA-5635838", "R-MMU-4641262", "R-MMU-216083", "R-CEL-4608870", "R-MMU-5620922", "R-DRE-4608870", "R-HSA-5620922", "R-DME-350379", "R-RNO-5632684", "R-HSA-201681", "R-RNO-4641262", "R-MMU-8856825", "R-HSA-3000157", "R-MMU-8948216", "R-RNO-5620922", "R-DME-350368", "R-DME-209338", "R-DME-209214", "R-HSA-5578768", "R-DME-5635838", "R-CEL-5140745", "R-HSA-5610787", "R-HSA-4641262", "R-HSA-5340588", "R-RNO-8856828", "R-HSA-4086398", "R-DME-209387", "R-RNO-5099900", "R-MMU-4608870", "R-DME-450728", "R-DME-216119", "R-GGA-5099900", "R-HSA-1442490", "R-HSA-3772470", "R-RNO-4608870", "R-HSA-216083", "R-DRE-5635838", "R-RNO-8856825", "R-DME-5620922", "R-HSA-4641263", "R-HSA-4086400", "R-HSA-5099900", "R-DME-350480", "R-HSA-1592389", "R-GGA-4086398", "R-GGA-4641263", "R-HSA-9673324", "R-HSA-5632684", "R-MMU-2022090", "R-RNO-4086398", "R-DME-209440", "R-MMU-1650814", "R-HSA-8856825", "R-MMU-1442490"], "pathways": ["R-DRE-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-GGA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-DME-216217:r:Activation of SMO", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DRE-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-5635838:r:Activation of SMO", "R-RNO-5610787:r:Hedgehog 'off' state", "R-DME-4086400:r:PCP/CE pathway", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DRE-5610787:r:Hedgehog 'off' state", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-8948216:r:Collagen chain trimerization", "R-DME-209472:r:Assembly of receptor complex", "R-CEL-4086398:r:Ca2+ pathway", "R-DME-5610787:r:Hedgehog 'off' state", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5578768:r:Physiological factors", "R-MMU-5635838:r:Activation of SMO", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-4086400:r:PCP/CE pathway", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-4086400:r:PCP/CE pathway", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-5578768:r:Physiological factors", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-5635838:r:Activation of SMO", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-216083:r:Integrin cell surface interactions", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209214:r:Phosphorylation of SMO", "R-HSA-5578768:r:Physiological factors", "R-DME-5635838:r:Activation of SMO", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-4086398:r:Ca2+ pathway", "R-DME-209387:r:Phosphorylation of ARR", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-DME-216119:r:Activation of CI", "R-GGA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-1442490:r:Collagen degradation", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-216083:r:Integrin cell surface interactions", "R-DRE-5635838:r:Activation of SMO", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-GGA-4086398:r:Ca2+ pathway", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-4086398:r:Ca2+ pathway", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-1442490:r:Collagen degradation"], "type": "Homologous_superfamily"}, "IPR036791": {"description": "Large ribosomal subunit protein bL9, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL9_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036792": {"description": "Aspartate carbamoyltransferase regulatory subunit, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Asp_carbatrfase_reg_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036793": {"description": "Aspartate carbamoyltransferase regulatory subunit, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Asp_carbatrfase_reg_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036794": {"description": "ATP synthase delta/epsilon subunit, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ATP_F1_dsu/esu_C_sf", "pathway_ids": ["R-BTA-163210", "R-RNO-163210", "R-RNO-8949613", "R-BTA-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210", "R-MMU-163210"], "pathways": ["R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-BTA-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Homologous_superfamily"}, "IPR036795": {"description": "Inosine monophosphate cyclohydrolase-like superfamily", "go_ids": ["GO:0006188", "GO:0006164", "GO:0003937"], "go_terms": ["GO:0006188:IMP biosynthetic 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cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-CFA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "type": "Homologous_superfamily"}, "IPR036797": {"description": "Acyl-CoA dehydrogenase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Acyl-CoA_dehydrogenase_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036798": {"description": "EF2947-like superfamily", "go_ids": [], "go_terms": [], "name": "EF2947-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036799": {"description": "Diphtheria toxin, receptor-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Diphtheria_tox_rcpt-bd_dom_sf", "pathway_ids": ["R-HSA-5336415"], "pathways": ["R-HSA-5336415:r:Uptake and function of diphtheria toxin"], "type": "Homologous_superfamily"}, "IPR036801": {"description": "Diphtheria toxin, translocation domain superfamily", "go_ids": [], "go_terms": [], "name": "Diphtheria_tox_transloc_sf", "pathway_ids": ["R-HSA-5336415"], "pathways": ["R-HSA-5336415:r:Uptake and function of diphtheria toxin"], "type": "Homologous_superfamily"}, "IPR036802": {"description": "ATP:guanido phosphotransferase, N-terminal domain superfamily", "go_ids": ["GO:0016301", "GO:0016772"], "go_terms": ["GO:0016301:kinase activity:F", "GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "ATP-guanido_PTrfase_N_sf", "pathway_ids": ["R-CFA-9696264", "R-MMU-71288", "R-HSA-71288", "R-BTA-9696264", "R-RNO-71288", "R-SSC-71288", "R-RNO-9696264", "R-CFA-71288", "R-MMU-9696264", "R-BTA-71288", "R-GGA-71288", "R-HSA-9696264", "R-GGA-9696264"], "pathways": ["R-CFA-9696264:r:RND3 GTPase cycle", "R-MMU-71288:r:Creatine metabolism", "R-HSA-71288:r:Creatine metabolism", "R-BTA-9696264:r:RND3 GTPase cycle", "R-RNO-71288:r:Creatine metabolism", "R-SSC-71288:r:Creatine metabolism", "R-RNO-9696264:r:RND3 GTPase cycle", "R-CFA-71288:r:Creatine metabolism", "R-MMU-9696264:r:RND3 GTPase cycle", "R-BTA-71288:r:Creatine metabolism", "R-GGA-71288:r:Creatine metabolism", "R-HSA-9696264:r:RND3 GTPase cycle", "R-GGA-9696264:r:RND3 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR036803": {"description": "Porphobilinogen deaminase, C-terminal domain superfamily", "go_ids": ["GO:0033014", "GO:0004418"], "go_terms": ["GO:0033014:tetrapyrrole biosynthetic process:P", "GO:0004418:hydroxymethylbilane synthase activity:F"], "name": "Porphobilinogen_deaminase_C_sf", "pathway_ids": ["PWY-5188", "PWY-5189", "R-RNO-189451", "R-BTA-189451", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "PWY-5189:t:tetrapyrrole biosynthesis II (from glycine)", "R-RNO-189451:r:Heme biosynthesis", "R-BTA-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Homologous_superfamily"}, "IPR036804": {"description": "Chemotaxis receptor methyltransferase CheR, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CheR_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036805": {"description": "Transcription elongation factor, GreA/GreB, N-terminal domain superfamily", "go_ids": ["GO:0032784", "GO:0003677"], "go_terms": ["GO:0032784:regulation of DNA-templated transcription elongation:P", "GO:0003677:DNA binding:F"], "name": "Tscrpt_elong_fac_GreA/B_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036806": {"description": "YozE SAM-like superfamily", "go_ids": [], "go_terms": [], "name": "YozE_SAM-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036807": {"description": "PH1570-like superfamily", "go_ids": [], "go_terms": [], "name": "PH1570-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036808": {"description": "PA1123-like superfamily", "go_ids": [], "go_terms": [], "name": "PA1123-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036809": {"description": "AF1782-like superfamily", "go_ids": [], "go_terms": [], "name": "AF1782-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036810": {"description": "SMc04008-like superfamily", "go_ids": [], "go_terms": [], "name": "SMc04008-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036811": {"description": "Ubiquinol-cytochrome C reductase hinge domain superfamily", "go_ids": [], "go_terms": [], "name": "Ubol_cytC_Rdtase_hinge_dom_sf", "pathway_ids": ["R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-HSA-9865881", "R-DDI-611105", "R-MMU-611105", "R-SPO-611105", "R-BTA-9865881", "R-RNO-9865881", "R-SCE-611105", "R-BTA-611105", "R-MMU-9865881"], "pathways": ["R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-9865881:r:Complex III assembly", "R-DDI-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-BTA-9865881:r:Complex III assembly", "R-RNO-9865881:r:Complex III assembly", "R-SCE-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR036812": {"description": "NAD(P)-dependent oxidoreductase domain superfamily", "go_ids": [], "go_terms": [], "name": "NAD(P)_OxRdtase_dom_sf", "pathway_ids": ["R-HSA-6798695", "R-RNO-193807", "R-DME-70221", "R-RNO-5423646", "R-HSA-5423646", "R-BTA-6798695", "R-DME-2162123", "R-BTA-9757110", "R-MMU-156590", "R-BTA-193368", "R-DME-5652227", "R-SPO-193807", "R-SPO-5661270", "R-MMU-975634", "R-DDI-5661270", "R-SCE-5652227", "R-MMU-5423646", 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"R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72702:r:Ribosomal scanning and 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and start codon recognition", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72649:r:Translation initiation complex formation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-GGA-5419276:r:Mitochondrial translation termination", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Homologous_superfamily"}, "IPR036824": {"description": "Nucleoplasmin core domain superfamily", "go_ids": [], "go_terms": [], "name": "Nucleoplasmin_core_dom_sf", "pathway_ids": ["R-HSA-606279", "R-HSA-9821993", "R-HSA-6804115", "R-HSA-9700645", "R-HSA-9833482", "R-MMU-3899300", "R-RNO-606279", "R-MMU-606279", "R-MMU-8869496", "R-RNO-6804115", "R-DME-9833482", "R-MMU-9833482", "R-HSA-9725371", "R-HSA-8869496", "R-RNO-8869496", "R-DME-3899300", "R-MMU-6804115", "R-HSA-3899300", "R-HSA-180746", "R-HSA-9692914", "R-HSA-9725370", "R-RNO-9833482", "R-DME-8869496", "R-RNO-3899300"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in 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acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-180746:r:Nuclear import of Rev protein", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "R-RNO-3899300:r:SUMOylation of transcription cofactors"], "type": "Homologous_superfamily"}, "IPR036825": {"description": "MTH865-like superfamily", "go_ids": [], "go_terms": [], "name": "MTH865-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036826": {"description": "Cytochrome f large domain superfamily", "go_ids": [], "go_terms": [], "name": "Cyt_f_lg_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036827": {"description": "She2 domain superfamily", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "She2_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036828": {"description": "TTHA1528-like superfamily", "go_ids": [], "go_terms": [], "name": "TTHA1528-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036829": {"description": "Hypothetical protein TM0875", "go_ids": [], "go_terms": [], "name": "TM0875", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036830": {"description": "Polyphosphate kinase middle domain superfamily", "go_ids": [], "go_terms": [], "name": "PP_kinase_middle_dom_sf", "pathway_ids": ["PWY-8138"], "pathways": ["PWY-8138:t:polyphosphate metabolism"], "type": "Homologous_superfamily"}, "IPR036831": {"description": "HNS-dependent expression A superfamily", "go_ids": ["GO:0071468", "GO:0030288"], "go_terms": ["GO:0071468:cellular response to acidic pH:P", "GO:0030288:outer membrane-bounded periplasmic space:C"], "name": "HdeA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036832": {"description": "Polyphosphate kinase N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PPK_N_dom_sf", "pathway_ids": ["PWY-8138"], "pathways": ["PWY-8138:t:polyphosphate metabolism"], "type": "Homologous_superfamily"}, "IPR036833": {"description": "Beta-galactosidase, domain 3 superfamily", "go_ids": [], "go_terms": [], "name": "BetaGal_dom3_sf", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Homologous_superfamily"}, "IPR036834": {"description": "Bcl-2-like superfamily", "go_ids": ["GO:0042981"], "go_terms": ["GO:0042981:regulation of apoptotic process:P"], "name": "Bcl-2-like_sf", 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"R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-5419276:r:Mitochondrial translation termination", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036839": {"description": "7,8-dihydroneopterin aldolase (MptD) superfamily", "go_ids": ["GO:0004150"], "go_terms": ["GO:0004150:dihydroneopterin aldolase activity:F"], "name": "MptD_sf", "pathway_ids": ["PWY-6147", "PWY-6148", "PWY-6797", "PWY-7539"], "pathways": ["PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", 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"R-BTA-114608:r:Platelet degranulation", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-194313:r:VEGF ligand-receptor interactions", "R-BTA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-BTA-194313:r:VEGF ligand-receptor interactions", "R-RNO-194313:r:VEGF ligand-receptor interactions"], "type": "Homologous_superfamily"}, "IPR036842": {"description": "AF2331-like superfamily", "go_ids": [], "go_terms": [], "name": "AF2331-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036843": {"description": "D-lysine 5,6-aminomutase beta subunit KamE, N-terminal domain superfamily", "go_ids": ["GO:0046983"], "go_terms": ["GO:0046983:protein dimerization activity:F"], "name": "KamE_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036844": {"description": "Hint domain superfamily", "go_ids": [], "go_terms": [], "name": "Hint_dom_sf", "pathway_ids": ["R-SCE-917977", "R-HSA-373080", "R-SCE-1222556", "R-DDI-76066", "R-DRE-5358346", "R-SCE-77387", "R-MMU-5635838", "R-SCE-9639288", "R-DME-5362798", "R-GGA-5632681", "R-HSA-9937080", "R-GGA-5358346", "R-RNO-5632681", "R-HSA-5632684", "R-DRE-5362798", "R-DME-5632681", "R-DME-209338", "R-DME-209471", "R-MMU-5632681", "R-HSA-5632681", "R-HSA-5362798", "R-HSA-8941284", "R-MMU-5362798", "R-HSA-5635838", "R-DDI-76061", "R-MMU-5358346", "R-DRE-5632681", "R-HSA-9758920", "R-HSA-5362768", "R-HSA-9796292", "R-HSA-5658034", "R-RNO-5362798", "R-GGA-5362798", "R-RNO-5358346", "R-HSA-9690406", "R-DME-5358346", "R-HSA-5358346"], "pathways": ["R-SCE-917977:r:Transferrin endocytosis and recycling", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-SCE-77387:r:Insulin receptor recycling", "R-MMU-5635838:r:Activation of SMO", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5632681:r:Ligand-receptor interactions", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-DME-5632681:r:Ligand-receptor interactions", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-5632681:r:Ligand-receptor interactions", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-5635838:r:Activation of SMO", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DRE-5632681:r:Ligand-receptor interactions", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-5658034:r:HHAT G278V doesn't palmitoylate Hh-Np", "R-RNO-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Homologous_superfamily"}, "IPR036845": {"description": "RecG, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RecG_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036846": {"description": "GM2-AP, lipid-recognition domain superfamily", "go_ids": [], "go_terms": [], "name": "GM2-AP_sf", "pathway_ids": ["R-SCE-6798695", "R-HSA-6798695", "R-DDI-6798695", "R-MMU-6798695", "R-DDI-8964038", "R-MMU-9840310", "R-SCE-8964038", "R-HSA-9840310"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-8964038:r:LDL clearance", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-SCE-8964038:r:LDL clearance", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Homologous_superfamily"}, "IPR036847": {"description": "Ribosome maturation factor RimP, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RimP_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036848": {"description": "Haemocyanin C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Haemocyanin_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036849": {"description": "Enolase-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Enolase-like_C_sf", "pathway_ids": ["PWY-1042", "PWY-8404", "PWY-2221", "PWY-1622", "PWY-7124", "PWY-6886", "PWY-6142", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901", "PWY-8004", "PWY-5484", "R-MMU-70171", "R-DRE-70263", "R-SCE-70171", "R-BTA-70171", "R-DME-70171", "R-PFA-70263", "R-MMU-70263", "R-CEL-70171", "R-GGA-352875", "R-DDI-70171", "R-DME-70263", "R-DDI-70263", "R-PFA-70171", "R-RNO-70171", "R-GGA-352882", "R-HSA-70263", "R-CEL-70263", "R-BTA-70263", "R-SPO-70263", "R-SCE-70263", "R-DRE-70171", "R-HSA-9636667", "R-HSA-70171", "R-SPO-70171", "R-RNO-70263"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8004:t:Entner-Doudoroff pathway I", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-MMU-70171:r:Glycolysis", "R-DRE-70263:r:Gluconeogenesis", "R-SCE-70171:r:Glycolysis", "R-BTA-70171:r:Glycolysis", "R-DME-70171:r:Glycolysis", "R-PFA-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-CEL-70171:r:Glycolysis", "R-GGA-352875:r:Gluconeogenesis", "R-DDI-70171:r:Glycolysis", "R-DME-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-PFA-70171:r:Glycolysis", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-DRE-70171:r:Glycolysis", "R-HSA-9636667:r:Manipulation of host energy metabolism", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR036850": {"description": "Nucleoside diphosphate kinase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "NDK-like_dom_sf", "pathway_ids": ["PWY-7198", "PWY-7221", "PWY-7205", "PWY-6545", "PWY-7226", "PWY-7176", "PWY-7222", "PWY-7184", "PWY-7224", "PWY-7187", "PWY-8289", "PWY-7220", "PWY-7197", "PWY-7227", "PWY-7210", "R-CFA-499943", "R-HSA-6798695", "R-SPO-6798695", "R-SSC-6798695", "R-GGA-499943", "R-DDI-9748787", "R-SCE-9755088", "R-MMU-5624138", "R-SCE-6798695", "R-BTA-6798695", "R-HSA-499943", "R-MMU-380320", "R-MMU-499943", "R-GGA-9755088", "R-RNO-380320", "R-MMU-9755088", "R-HSA-380320", "R-BTA-9755088", "R-HSA-9636383", "R-DRE-5624138", "R-DME-499943", "R-DME-9748787", "R-DME-9755088", "R-SSC-9755088", "R-BTA-380320", "R-HSA-9755088", "R-CFA-9748787", "R-RNO-9748787", "R-DDI-499943", "R-MMU-9748787", "R-DDI-6798695", "R-SCE-9748787", "R-DDI-9755088", "R-SSC-499943", "R-DME-6798695", "R-RNO-9755088", "R-CFA-9755088", "R-MMU-380270", "R-HSA-5624138", "R-SCE-499943", "R-HSA-380270", "R-SPO-499943", "R-GGA-6798695", "R-HSA-9748787", "R-BTA-380270", "R-BTA-9748787", "R-BTA-499943", "R-SPO-9755088", "R-MMU-6798695", "R-SPO-9748787", "R-SSC-9748787", "R-RNO-380270", "R-RNO-6798695", "R-RNO-499943"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-7221:t:guanosine ribonucleotides de novo biosynthesis", "PWY-7205:t:CMP phosphorylation", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7176:t:UTP and CTP de novo biosynthesis", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7224:t:purine deoxyribonucleosides salvage", "PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II", "PWY-8289:t:dZTP biosynthesis", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7197:t:pyrimidine deoxyribonucleotide phosphorylation", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-CFA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-GGA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DDI-9748787:r:Azathioprine ADME", "R-SCE-9755088:r:Ribavirin ADME", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-GGA-9755088:r:Ribavirin ADME", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-9755088:r:Ribavirin ADME", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-9755088:r:Ribavirin ADME", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-9748787:r:Azathioprine ADME", "R-DME-9755088:r:Ribavirin ADME", "R-SSC-9755088:r:Ribavirin ADME", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-9755088:r:Ribavirin ADME", "R-CFA-9748787:r:Azathioprine ADME", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-9748787:r:Azathioprine ADME", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-9748787:r:Azathioprine ADME", "R-DDI-9755088:r:Ribavirin ADME", "R-SSC-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-9755088:r:Ribavirin ADME", "R-CFA-9755088:r:Ribavirin ADME", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-9748787:r:Azathioprine ADME", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-9748787:r:Azathioprine ADME", "R-BTA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-9755088:r:Ribavirin ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-9748787:r:Azathioprine ADME", "R-SSC-9748787:r:Azathioprine ADME", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Homologous_superfamily"}, "IPR036851": {"description": "Chloroperoxidase-like superfamily", "go_ids": ["GO:0004601"], "go_terms": ["GO:0004601:peroxidase activity:F"], "name": "Chloroperoxidase-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036852": {"description": "Peptidase S8/S53 domain superfamily", "go_ids": ["GO:0006508", "GO:0004252"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0004252:serine-type endopeptidase activity:F"], "name": "Peptidase_S8/S53_dom_sf", "pathway_ids": ["PWY-7884", "R-HSA-186797", "R-CEL-1592389", "R-DME-2173789", "R-DDI-983170", "R-HSA-159782", "R-HSA-171286", "R-HSA-8963889", "R-HSA-264876", "R-HSA-9918485", "R-RNO-381033", "R-CEL-1566948", "R-RNO-8964038", "R-MMU-8957275", "R-MMU-422085", "R-MMU-1912420", "R-HSA-9828806", "R-DDI-193368", "R-MMU-381426", "R-RNO-8963889", "R-RNO-422085", "R-HSA-5210891", "R-MMU-1655829", "R-MMU-1566948", "R-RNO-9768727", "R-HSA-209952", "R-RNO-8866427", "R-HSA-381426", "R-HSA-2173789", "R-MMU-381033", "R-MMU-1592389", "R-MMU-2173796", "R-CEL-2173796", "R-HSA-9694614", "R-DME-1592389", "R-RNO-1566948", "R-HSA-422085", "R-RNO-8874211", "R-HSA-381033", "R-HSA-9820960", "R-RNO-381426", "R-SPO-8866427", "R-MMU-8866427", "R-HSA-9918476", "R-HSA-167060", "R-SCE-2173796", "R-HSA-9768727", "R-SCE-8866427", "R-MMU-186797", "R-MMU-9768727", "R-RNO-983168", "R-RNO-2173796", "R-DME-983168", "R-DDI-382556", "R-SPO-2173796", "R-HSA-6809371", "R-HSA-9662834", "R-HSA-977225", "R-RNO-159782", "R-RNO-8874177", "R-HSA-1566948", "R-HSA-8874211", "R-MMU-8874211", "R-CEL-983168", "R-DDI-9757110", "R-MMU-209952", "R-DDI-9754706", "R-MMU-9953170", "R-RNO-1655829", "R-SPO-8964038", "R-HSA-1181150", "R-DME-8963889", "R-PFA-2173796", "R-RNO-8957275", "R-MMU-8964038", "R-SPO-983168", "R-MMU-167060", "R-HSA-381771", "R-SCE-8964038", "R-HSA-2173796", "R-RNO-2173789", "R-HSA-1442490", "R-HSA-400511", "R-HSA-1912420", "R-HSA-1655829", "R-HSA-381038", "R-RNO-9953170", "R-MMU-2173789", "R-HSA-9733458", "R-RNO-1592389", "R-RNO-186797", "R-MMU-8963889", "R-HSA-9679191", "R-HSA-1592389", "R-HSA-983168", "R-RNO-1442490", "R-RNO-209952", "R-HSA-8866427", "R-DDI-159418", "R-MMU-8874177", "R-MMU-159782", "R-HSA-8874177", "R-RNO-167060", "R-MMU-983168", "R-DME-2173796", "R-HSA-8957275", "R-CEL-186797", "R-MMU-1442490", "R-HSA-8964038", "R-HSA-9953170", "R-DME-186797"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-HSA-186797:r:Signaling by PDGF", "R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-171286:r:Synthesis and processing of ENV and VPU", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-264876:r:Insulin processing", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-CEL-1566948:r:Elastic fibre formation", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-1566948:r:Elastic fibre formation", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-209952:r:Peptide hormone biosynthesis", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9694614:r:Attachment and Entry", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1566948:r:Elastic fibre formation", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-8874211:r:CREB3 factors activate genes", "R-HSA-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-167060:r:NGF processing", "R-SCE-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-SPO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-HSA-1566948:r:Elastic fibre formation", "R-HSA-8874211:r:CREB3 factors activate genes", "R-MMU-8874211:r:CREB3 factors activate genes", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9757110:r:Prednisone ADME", "R-MMU-209952:r:Peptide hormone biosynthesis", "R-DDI-9754706:r:Atorvastatin ADME", "R-MMU-9953170:r:GBP-mediated host defense", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-SPO-8964038:r:LDL clearance", "R-HSA-1181150:r:Signaling by NODAL", "R-DME-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-PFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8964038:r:LDL clearance", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-167060:r:NGF processing", "R-HSA-381771:r:Synthesis, secretion, and inactivation of 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"R-HSA-6791226", "R-RNO-975956", "R-DDI-156827", "R-SSC-72689", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-MMU-5389840", "R-SPO-72689", "R-CEL-72689", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-9937383", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-DRE-9937383", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-RNO-5389840", "R-MMU-975956", "R-DRE-5419276", "R-DRE-156827", "R-SCE-156827", "R-DME-975956", "R-DRE-975956", "R-BTA-9954716", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-9937383", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-BTA-1799339", "R-DRE-5389840", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-DRE-72689", "R-BTA-975956", 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the 60S ribosomal subunit", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin 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ribosome-associated quality control", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036854": {"description": "Photosystem II protein D1/D2 superfamily", "go_ids": ["GO:0019684", "GO:0009772"], "go_terms": ["GO:0019684:photosynthesis, light reaction:P", "GO:0009772:photosynthetic electron transport in photosystem II:P"], "name": "Photo_II_D1/D2_sf", "pathway_ids": ["PWY-101"], "pathways": ["PWY-101:t:photosynthesis light reactions"], "type": "Homologous_superfamily"}, "IPR036855": {"description": "Zinc finger, CCCH-type superfamily", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "Znf_CCCH_sf", "pathway_ids": ["R-RNO-9629569", "R-HSA-6807505", "R-MMU-9770562", "R-MMU-198323", "R-CEL-450385", "R-HSA-73856", "R-RNO-72163", "R-RNO-450513", "R-HSA-72187", "R-SPO-9930044", "R-DME-9930044", "R-MMU-8948751", "R-DRE-198323", "R-SPO-198323", "R-HSA-9834752", "R-SCE-450385", "R-SCE-198323", "R-RNO-73856", "R-HSA-9828806", "R-RNO-450385", "R-DRE-9629569", "R-DME-73856", "R-HSA-9629569", "R-MMU-9930044", "R-DRE-8948751", "R-HSA-429947", "R-SCE-77595", "R-MMU-72163", "R-HSA-6784531", "R-BTA-73856", "R-DME-9629569", "R-MMU-73856", "R-HSA-168315", "R-CEL-450513", "R-SPO-77595", "R-MMU-6807505", "R-HSA-9820960", "R-HSA-9828721", "R-HSA-159231", "R-HSA-72163", "R-DME-6807505", "R-SPO-9770562", "R-HSA-9820841", "R-HSA-8948751", "R-BTA-9770562", "R-CEL-8948751", "R-XTR-9629569", "R-SPO-8948751", "R-BTA-9629569", "R-MMU-450385", "R-DME-983168", "R-HSA-9930044", "R-DME-77595", "R-SPO-159231", "R-XTR-9770562", "R-MMU-77595", "R-RNO-77595", "R-DME-159231", "R-RNO-9930044", "R-CEL-983168", "R-HSA-198323", "R-DRE-983168", "R-HSA-77595", "R-DRE-72163", "R-SCE-8948751", "R-DME-9770562", "R-MMU-429947", "R-HSA-6782315", "R-XTR-77595", "R-SPO-983168", "R-HSA-72165", "R-HSA-9833110", "R-SCE-983168", "R-CEL-72163", "R-HSA-9918481", "R-MMU-159231", "R-BTA-77595", "R-HSA-9820962", "R-HSA-9770562", "R-HSA-9828642", "R-BTA-72165", "R-DDI-9629569", "R-SCE-450513", "R-DME-450385", "R-HSA-983168", "R-PFA-72163", "R-HSA-450385", "R-MMU-9629569", "R-MMU-450513", "R-MMU-72187", "R-MMU-72165", "R-DME-450513", "R-RNO-159231", "R-HSA-450513", "R-RNO-9770562", "R-MMU-983168", "R-BTA-159231", "R-CEL-198323", "R-DRE-72165"], "pathways": ["R-RNO-9629569:r:Protein hydroxylation", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-RNO-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-9930044:r:Nuclear RNA decay", "R-DME-9930044:r:Nuclear RNA decay", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-9834752:r:Respiratory syncytial virus genome replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-RNO-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-9629569:r:Protein hydroxylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9629569:r:Protein hydroxylation", "R-MMU-9930044:r:Nuclear RNA decay", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-HSA-429947:r:Deadenylation of mRNA", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-9629569:r:Protein hydroxylation", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-168315:r:Inhibition of Host mRNA Processing and RNA Silencing", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-9770562:r:mRNA Polyadenylation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-XTR-9629569:r:Protein hydroxylation", "R-SPO-8948751:r:Regulation of PTEN stability and activity", "R-BTA-9629569:r:Protein hydroxylation", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9930044:r:Nuclear RNA decay", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-XTR-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-9930044:r:Nuclear RNA decay", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-XTR-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9833110:r:RSV-host interactions", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9828642:r:Respiratory syncytial virus genome transcription", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-9629569:r:Protein hydroxylation", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-PFA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-9629569:r:Protein hydroxylation", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DME-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-72165:r:mRNA Splicing - Minor Pathway"], "type": "Homologous_superfamily"}, "IPR036856": {"description": "Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily", "go_ids": [], "go_terms": [], "name": "Ald_Oxase/Xan_DH_a/b_sf", "pathway_ids": ["R-MMU-9748787", "R-RNO-8851680", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", "R-RNO-74259", "R-GGA-421178", "R-DME-964975", "R-MMU-8851680", "R-HSA-9748787", "R-HSA-74259", "R-RNO-964975", "R-DME-74259", "R-MMU-964975", "R-CEL-964975", "R-DME-9748787", "R-MMU-74259", "R-DDI-964975", "R-RNO-9748787", "R-DDI-74259"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-GGA-421178:r:Urate synthesis", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-74259:r:Purine catabolism", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Homologous_superfamily"}, "IPR036857": {"description": "Thyroglobulin type-1 superfamily", "go_ids": [], "go_terms": [], "name": "Thyroglobulin_1_sf", "pathway_ids": ["R-HSA-2132295", "R-XTR-381426", "R-HSA-3000157", "R-RNO-3000157", "R-SSC-202733", "R-HSA-9927418", "R-MMU-8957275", "R-BTA-8957275", "R-HSA-9638630", "R-HSA-380994", "R-HSA-9615017", "R-RNO-202733", "R-RNO-8957275", "R-MMU-202733", "R-MMU-2132295", "R-BTA-381426", "R-MMU-381426", "R-HSA-9938206", "R-HSA-6803211", "R-RNO-6803211", "R-MMU-6803211", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-9925563", "R-RNO-2132295", "R-MMU-3000157", "R-SSC-381426", "R-SSC-8957275", "R-MMU-1592389", "R-HSA-9927432", "R-GGA-202733", "R-HSA-1592389", "R-RNO-381426", "R-DRE-381426", "R-HSA-8957275", "R-BTA-6803211", "R-HSA-202733", "R-HSA-9927426"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-XTR-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3000157:r:Laminin interactions", "R-RNO-3000157:r:Laminin interactions", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-RNO-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-MMU-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-3000157:r:Laminin interactions", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Homologous_superfamily"}, "IPR036858": {"description": "Cyclin-dependent kinase, regulatory subunit superfamily", "go_ids": ["GO:0016538"], "go_terms": ["GO:0016538:cyclin-dependent protein serine/threonine kinase regulator activity:F"], "name": "Cyclin-dep_kinase_reg-sub_sf", "pathway_ids": ["R-BTA-69231", "R-HSA-187577", "R-MMU-187577", "R-DME-187577", "R-BTA-187577", "R-DDI-69231", "R-DME-69231", "R-HSA-69231", "R-DDI-187577", "R-MMU-69231"], "pathways": ["R-BTA-69231:r:Cyclin D associated events in G1", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-69231:r:Cyclin D associated events in G1", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Homologous_superfamily"}, "IPR036859": {"description": "CAP Gly-rich domain superfamily", "go_ids": [], "go_terms": [], "name": "CAP-Gly_dom_sf", "pathway_ids": ["R-HSA-9842640", "R-SSC-3371497", "R-HSA-168638", "R-BTA-5689880", "R-BTA-5357786", "R-MMU-2467813", "R-HSA-5689880", "R-HSA-380284", "R-RNO-5357905", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-DDI-5626467", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5689880", "R-HSA-6811434", "R-SSC-2132295", "R-RNO-380284", "R-SSC-2565942", "R-MMU-5620912", "R-HSA-389977", "R-SSC-8854518", "R-MMU-141444", "R-SSC-380259", "R-MMU-380259", "R-MMU-380270", "R-HSA-141444", "R-HSA-9648025", "R-RNO-5663220", "R-HSA-5357786", "R-RNO-5689880", "R-MMU-6811436", "R-SSC-380284", "R-RNO-6811436", "R-SSC-6807878", "R-MMU-5357905", "R-RNO-936440", "R-MMU-8854518", "R-RNO-168638", "R-RNO-2467813", "R-RNO-380270", "R-MMU-3371497", "R-MMU-5663220", "R-RNO-141444", "R-SSC-380270", "R-HSA-2132295", "R-HSA-2467813", "R-HSA-5626467", "R-BTA-5357956", "R-RNO-2500257", "R-RNO-3371497", "R-HSA-936440", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-MMU-5357956", "R-HSA-2565942", "R-HSA-9725370", "R-HSA-5357905", "R-RNO-2565942", "R-BTA-936440", "R-HSA-68877", "R-MMU-2132295", "R-MMU-168638", "R-HSA-5620912", "R-BTA-168638", "R-MMU-9648025", "R-HSA-6811436", "R-MMU-2500257", "R-HSA-381038", "R-RNO-2132295", "R-MMU-5357786", "R-HSA-2500257", "R-MMU-5626467", "R-RNO-68877", "R-RNO-8854518", "R-RNO-6807878", "R-RNO-5626467", "R-HSA-6807878", "R-HSA-380270", "R-RNO-380259", "R-HSA-5357956", "R-HSA-983189", "R-RNO-5357956", "R-SSC-380320", "R-HSA-5663220", "R-MMU-936440", "R-RNO-9648025", "R-RNO-5357786", "R-HSA-380259", "R-BTA-5357905", "R-SSC-5620912"], "pathways": ["R-HSA-9842640:r:Signaling by LTK in cancer", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SSC-2132295:r:MHC class II antigen presentation", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-983189:r:Kinesins", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Homologous_superfamily"}, "IPR036860": {"description": "SH2 domain superfamily", "go_ids": [], "go_terms": [], "name": "SH2_dom_sf", "pathway_ids": ["R-HSA-9020558", "R-CEL-9013423", "R-BTA-512988", "R-DME-5654699", "R-HSA-1963640", "R-MMU-912631", "R-CEL-75955", "R-RNO-8875791", "R-RNO-9603381", "R-DME-112412", "R-MMU-9706369", "R-RNO-391160", "R-BTA-9009391", "R-RNO-69231", "R-MMU-5654726", "R-HSA-8939902", "R-RNO-1660499", "R-DDI-9701898", "R-BTA-9013404", "R-HSA-877300", "R-BTA-1257604", "R-SSC-983231", "R-CEL-9013420", "R-BTA-167044", "R-CEL-9009391", "R-RNO-5654219", "R-BTA-9607240", "R-MMU-9013149", "R-GGA-372708", "R-DDI-9008059", "R-MMU-182971", 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"R-CEL-877312", "R-BTA-210993", "R-XTR-5654689", "R-HSA-674695", "R-DRE-418592", "R-CEL-6798695", "R-SSC-6785807", "R-MMU-8875791", "R-HSA-9670439", "R-MMU-8865999", "R-MMU-432142", "R-RNO-912526", "R-MMU-8951664", "R-DME-2029482", "R-RNO-202427", "R-BTA-8866376", "R-HSA-111453", "R-BTA-8853659", "R-CEL-5654700", "R-BTA-1251985", "R-MMU-2029485", "R-RNO-9013404", "R-XTR-182971", "R-HSA-9013408", "R-CEL-3928662", "R-HSA-1266695", "R-RNO-9927354", "R-MMU-2428933", "R-HSA-9706374", "R-SSC-74749", "R-DRE-418594", "R-DRE-1253288", "R-HSA-3928664", "R-RNO-8984722", "R-RNO-3928663", "R-SSC-512988", "R-CEL-8939236", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-1433557", "R-DME-2871796", "R-CEL-212718", "R-DRE-399956", "R-SSC-389359", "R-BTA-8854691", "R-HSA-1257604", "R-MMU-5654710", "R-DRE-1660499", "R-HSA-74751", "R-DME-5654693", "R-SSC-6783783", "R-DME-525793", "R-HSA-1251932", "R-HSA-1250347", "R-CEL-8854691", "R-CEL-1251985", "R-MMU-198203", "R-CEL-909733", "R-RNO-5663213", "R-HSA-9673770", "R-BTA-201556", "R-HSA-9035034", "R-HSA-8849473", "R-XTR-5654700", "R-HSA-8851805", "R-MMU-5218921", "R-GGA-1257604", "R-BTA-2029485", "R-BTA-1306955", "R-BTA-9013420", "R-RNO-5654706", "R-HSA-9020591", "R-SSC-9008059", "R-GGA-2454202", "R-DME-8876198", "R-MMU-428890", "R-SSC-2424491", "R-RNO-982772", "R-HSA-983168", "R-DME-877312", "R-MMU-2029482", "R-BTA-74749", "R-SSC-5673001", "R-RNO-2424491", "R-RNO-8941858", "R-SSC-3928665", "R-RNO-5654700", "R-HSA-389948", "R-HSA-202424", "R-MMU-912694", "R-HSA-5663213", "R-SSC-5673000", "R-CEL-8849470", "R-RNO-6785807", "R-DME-877300", "R-RNO-8948751", "R-MMU-1266695", "R-BTA-9696273", "R-MMU-114604", "R-HSA-9833482", "R-DDI-8984722", "R-RNO-2428933", "R-BTA-5654719", "R-HSA-167021", "R-RNO-9607240", "R-XTR-2730905", "R-CEL-5621575", "R-RNO-8854691", "R-MMU-75955", "R-RNO-9634597", "R-CEL-5654695", "R-HSA-8939245", "R-RNO-6811558", "R-MMU-8851805", "R-DME-74751", "R-HSA-9603381", "R-DME-3928664", "R-SSC-982772", "R-CEL-9008059", "R-DME-3249367", "R-HSA-9616222", "R-SSC-9674555", "R-GGA-8875555", "R-HSA-5654727", "R-BTA-8983432", "R-GGA-2871809", "R-RNO-9020958", "R-MMU-9013423", "R-HSA-5654699", "R-RNO-8875656", "R-HSA-1295596", "R-RNO-8851805", "R-RNO-9006335", "R-RNO-8951664", "R-HSA-1236974", "R-SSC-1433557", "R-RNO-6798695", "R-HSA-9656223", "R-BTA-2029482", "R-BTA-5654688", "R-MMU-8934903", "R-HSA-9705671", "R-RNO-9842663", "R-MMU-5654699", "R-BTA-202427", "R-MMU-9020956", "R-RNO-75892", "R-RNO-1253288", "R-BTA-1250347", "R-MMU-8847993", "R-HSA-2730905", "R-MMU-111465", "R-MMU-9027284", "R-BTA-1433557"], "pathways": ["R-HSA-9020558:r:Interleukin-2 signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-912631:r:Regulation of signaling by CBL", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-DME-112412:r:SOS-mediated signalling", "R-MMU-9706369:r:Negative regulation of FLT3", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DDI-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-HSA-877300:r:Interferon gamma signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9013420:r:RHOU GTPase cycle", "R-BTA-167044:r:Signalling to RAS", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-BTA-9607240:r:FLT3 Signaling", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DDI-9008059:r:Interleukin-37 signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-8964315:r:G beta:gamma signalling through BTK", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-BTA-373753:r:Nephrin family interactions", "R-GGA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-GGA-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-114604:r:GPVI-mediated activation cascade", "R-HSA-432142:r:Platelet sensitization by LDL", "R-RNO-74749:r:Signal attenuation", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DRE-191650:r:Regulation of gap junction activity", "R-XTR-389359:r:CD28 dependent Vav1 pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-GGA-8875656:r:MET receptor recycling", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-DME-1266695:r:Interleukin-7 signaling", "R-HSA-164944:r:Nef and signal transduction", "R-SSC-877300:r:Interferon gamma signaling", "R-BTA-877300:r:Interferon gamma signaling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-XTR-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-5621480:r:Dectin-2 family", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-DME-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-GGA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-DDI-877312:r:Regulation of IFNG signaling", "R-BTA-8951664:r:Neddylation", "R-HSA-449836:r:Other interleukin signaling", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-3928664:r:Ephrin signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-GGA-389513:r:Co-inhibition by CTLA4", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-XTR-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-SSC-1433559:r:Regulation of KIT signaling", "R-CEL-6807004:r:Negative regulation of MET activity", "R-XTR-186763:r:Downstream signal transduction", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-BTA-9020958:r:Interleukin-21 signaling", "R-DDI-201556:r:Signaling by ALK", "R-DME-8854691:r:Interleukin-20 family signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-877300:r:Interferon gamma signaling", "R-GGA-1433559:r:Regulation of KIT signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-418594:r:G alpha (i) signalling events", "R-GGA-170984:r:ARMS-mediated activation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-XTR-8853659:r:RET signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9696270:r:RND2 GTPase cycle", "R-XTR-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-9842640:r:Signaling by LTK in cancer", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-198203:r:PI3K/AKT activation", "R-SSC-9607240:r:FLT3 Signaling", "R-XTR-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-SSC-210990:r:PECAM1 interactions", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-170984:r:ARMS-mediated activation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-109704:r:PI3K Cascade", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-5673000:r:RAF activation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-5673000:r:RAF activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-1059683:r:Interleukin-6 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-SSC-375165:r:NCAM signaling for neurite out-growth", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-XTR-5654706:r:FRS-mediated FGFR3 signaling", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-CEL-877300:r:Interferon gamma signaling", "R-CEL-9748787:r:Azathioprine ADME", "R-RNO-912694:r:Regulation of IFNA/IFNB signaling", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-RNO-177929:r:Signaling by EGFR", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-XTR-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-112399:r:IRS-mediated signalling", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9706369:r:Negative regulation of FLT3", "R-DDI-9833482:r:PKR-mediated signaling", "R-BTA-180292:r:GAB1 signalosome", "R-XTR-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1227986:r:Signaling by ERBB2", "R-GGA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-428540:r:Activation of RAC1", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-9833482:r:PKR-mediated signaling", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-DDI-9020591:r:Interleukin-12 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-1266695:r:Interleukin-7 signaling", "R-RNO-5621480:r:Dectin-2 family", "R-XTR-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1227986:r:Signaling by ERBB2", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-DDI-9020933:r:Interleukin-23 signaling", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-XTR-5654695:r:PI-3K cascade:FGFR2", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-GGA-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9013408:r:RHOG GTPase cycle", "R-BTA-8875513:r:MET interacts with TNS proteins", "R-BTA-9706369:r:Negative regulation of FLT3", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-XTR-74751:r:Insulin receptor signalling cascade", "R-HSA-373753:r:Nephrin family interactions", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-201556:r:Signaling by ALK", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-XTR-109704:r:PI3K Cascade", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DRE-354192:r:Integrin signaling", "R-CEL-9020591:r:Interleukin-12 signaling", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-8853659:r:RET signaling", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-CEL-8849472:r:PTK6 Down-Regulation", "R-HSA-167044:r:Signalling to RAS", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-XTR-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-109704:r:PI3K Cascade", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-MMU-9842663:r:Signaling by LTK", "R-SSC-8985947:r:Interleukin-9 signaling", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DDI-877300:r:Interferon gamma signaling", "R-DME-9748787:r:Azathioprine ADME", "R-DDI-9020956:r:Interleukin-27 signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-HSA-525793:r:Myogenesis", "R-MMU-389948:r:Co-inhibition by PD-1", "R-DME-180292:r:GAB1 signalosome", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-9645135:r:STAT5 Activation", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-GGA-389356:r:Co-stimulation by CD28", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-HSA-1227986:r:Signaling by ERBB2", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-DDI-1059683:r:Interleukin-6 signaling", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-CEL-8984722:r:Interleukin-35 Signalling", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-8866376:r:Reelin signalling pathway", "R-RNO-182971:r:EGFR downregulation", "R-DDI-8983432:r:Interleukin-15 signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-RNO-373753:r:Nephrin family interactions", "R-RNO-1433559:r:Regulation of KIT signaling", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5673000:r:RAF activation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-112412:r:SOS-mediated signalling", "R-XTR-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-SSC-389356:r:Co-stimulation by CD28", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-DME-8985947:r:Interleukin-9 signaling", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DRE-430116:r:GP1b-IX-V activation signalling", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-MMU-193648:r:NRAGE signals death through JNK", "R-XTR-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-8983432:r:Interleukin-15 signaling", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-182971:r:EGFR downregulation", "R-HSA-8985947:r:Interleukin-9 signaling", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-CEL-3249367:r:STAT6-mediated induction of chemokines", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-112412:r:SOS-mediated signalling", "R-XTR-1295596:r:Spry regulation of FGF signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-109704:r:PI3K Cascade", "R-GGA-210993:r:Tie2 Signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-9927353:r:Co-inhibition by BTLA", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-BTA-109704:r:PI3K Cascade", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-5654695:r:PI-3K cascade:FGFR2", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-201556:r:Signaling by ALK", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-MMU-74749:r:Signal attenuation", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-CEL-373753:r:Nephrin family interactions", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9607240:r:FLT3 Signaling", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-RNO-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-912631:r:Regulation of signaling by CBL", "R-SSC-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-9020956:r:Interleukin-27 signaling", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-BTA-9035034:r:RHOF GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-DME-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1433559:r:Regulation of KIT signaling", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-177929:r:Signaling by EGFR", "R-XTR-180336:r:SHC1 events in EGFR signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-GGA-180292:r:GAB1 signalosome", "R-RNO-201556:r:Signaling by ALK", "R-BTA-9013407:r:RHOH GTPase cycle", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-DME-9020933:r:Interleukin-23 signaling", "R-SSC-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-BTA-912631:r:Regulation of signaling by CBL", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-5654720:r:PI-3K cascade:FGFR4", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-BTA-389948:r:Co-inhibition by PD-1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-BTA-9013106:r:RHOC GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-BTA-9766229:r:Degradation of CDH1", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-XTR-5654710:r:PI-3K cascade:FGFR3", "R-BTA-1059683:r:Interleukin-6 signaling", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-SSC-9020958:r:Interleukin-21 signaling", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-9020956:r:Interleukin-27 signaling", "R-SSC-399956:r:CRMPs in Sema3A signaling", "R-MMU-202433:r:Generation of second messenger molecules", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-DRE-9020958:r:Interleukin-21 signaling", "R-DME-9008059:r:Interleukin-37 signaling", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-DDI-6783783:r:Interleukin-10 signaling", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-BTA-9013408:r:RHOG GTPase cycle", "R-DRE-8853659:r:RET signaling", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-SSC-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-GGA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-DME-201556:r:Signaling by ALK", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-9008059:r:Interleukin-37 signaling", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9696273:r:RND1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-RNO-9013026:r:RHOB GTPase cycle", "R-XTR-6807004:r:Negative regulation of MET activity", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-RNO-9020591:r:Interleukin-12 signaling", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-198745:r:Signalling to STAT3", "R-XTR-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-9013407:r:RHOH GTPase cycle", "R-SSC-9833482:r:PKR-mediated signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-XTR-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-210990:r:PECAM1 interactions", "R-SSC-912631:r:Regulation of signaling by CBL", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-GGA-1059683:r:Interleukin-6 signaling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-GGA-877312:r:Regulation of IFNG signaling", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DRE-1227986:r:Signaling by ERBB2", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9634597:r:GPER1 signaling", "R-SSC-1266695:r:Interleukin-7 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-DRE-877312:r:Regulation of IFNG signaling", "R-SSC-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-373753:r:Nephrin family interactions", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-RNO-354192:r:Integrin signaling", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-MMU-5621480:r:Dectin-2 family", "R-GGA-912631:r:Regulation of signaling by CBL", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-BTA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-74749:r:Signal attenuation", "R-BTA-418885:r:DCC mediated attractive signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-SSC-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-DME-186763:r:Downstream signal transduction", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-210993:r:Tie2 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-XTR-912631:r:Regulation of signaling by CBL", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-191650:r:Regulation of gap junction activity", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-198203:r:PI3K/AKT activation", "R-DRE-69231:r:Cyclin D associated events in G1", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DRE-877300:r:Interferon gamma signaling", "R-BTA-112399:r:IRS-mediated signalling", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-BTA-877312:r:Regulation of IFNG signaling", "R-GGA-5654720:r:PI-3K cascade:FGFR4", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-XTR-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-SSC-186763:r:Downstream signal transduction", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-XTR-9027284:r:Erythropoietin activates RAS", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-8849474:r:PTK6 Activates STAT3", "R-GGA-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-XTR-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-GGA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-SSC-877312:r:Regulation of IFNG signaling", "R-XTR-9607240:r:FLT3 Signaling", "R-SSC-9706369:r:Negative regulation of FLT3", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SSC-8853659:r:RET signaling", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-DRE-1059683:r:Interleukin-6 signaling", "R-BTA-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CEL-202433:r:Generation of second messenger molecules", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-XTR-8865999:r:MET activates PTPN11", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-CFA-912526:r:Interleukin receptor SHC signaling", "R-SSC-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-9766229:r:Degradation of CDH1", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-DME-209405:r:JAK/STAT pathway", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-8983432:r:Interleukin-15 signaling", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-DME-9013148:r:CDC42 GTPase cycle", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-DDI-8854691:r:Interleukin-20 family signaling", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-9020558:r:Interleukin-2 signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DRE-5621480:r:Dectin-2 family", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-BTA-9634597:r:GPER1 signaling", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-DME-1433559:r:Regulation of KIT signaling", "R-GGA-5654689:r:PI-3K cascade:FGFR1", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-RNO-2029481:r:FCGR activation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-XTR-5654704:r:SHC-mediated cascade:FGFR3", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-BTA-2424491:r:DAP12 signaling", "R-SSC-1227986:r:Signaling by ERBB2", "R-RNO-9035034:r:RHOF GTPase cycle", "R-GGA-8951664:r:Neddylation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-CEL-8983432:r:Interleukin-15 signaling", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-BTA-9696270:r:RND2 GTPase cycle", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-DME-167044:r:Signalling to RAS", "R-BTA-1250196:r:SHC1 events in ERBB2 signaling", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-SSC-74713:r:IRS activation", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-525793:r:Myogenesis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-8985947:r:Interleukin-9 signaling", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-DRE-6783783:r:Interleukin-10 signaling", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-112399:r:IRS-mediated signalling", "R-XTR-179812:r:GRB2 events in EGFR signaling", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-GGA-109704:r:PI3K Cascade", "R-HSA-6783783:r:Interleukin-10 signaling", "R-XTR-2424491:r:DAP12 signaling", "R-GGA-8854691:r:Interleukin-20 family signaling", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-BTA-74751:r:Insulin receptor signalling cascade", "R-XTR-9842663:r:Signaling by LTK", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-GGA-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-9696273:r:RND1 GTPase cycle", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-DRE-177929:r:Signaling by EGFR", "R-HSA-9620244:r:Long-term potentiation", "R-GGA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-CEL-9020933:r:Interleukin-23 signaling", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-XTR-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-201556:r:Signaling by ALK", "R-XTR-167044:r:Signalling to RAS", "R-HSA-198203:r:PI3K/AKT activation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-69231:r:Cyclin D associated events in G1", "R-XTR-2871796:r:FCERI mediated MAPK activation", "R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-389356:r:Co-stimulation by CD28", "R-RNO-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DME-8984722:r:Interleukin-35 Signalling", "R-CEL-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-170984:r:ARMS-mediated activation", "R-HSA-171007:r:p38MAPK events", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-GGA-210990:r:PECAM1 interactions", "R-DME-909733:r:Interferon alpha/beta signaling", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-180292:r:GAB1 signalosome", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-112399:r:IRS-mediated signalling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-SSC-8875791:r:MET activates STAT3", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-DRE-373753:r:Nephrin family interactions", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-912631:r:Regulation of signaling by CBL", "R-DME-9020558:r:Interleukin-2 signaling", "R-XTR-112412:r:SOS-mediated signalling", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-GGA-354192:r:Integrin signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-GGA-5654695:r:PI-3K cascade:FGFR2", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-210693:r:STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-8866376:r:Reelin signalling pathway", "R-BTA-9674555:r:Signaling by CSF3 (G-CSF)", "R-DDI-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-186763:r:Downstream signal transduction", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-74713:r:IRS activation", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9927353:r:Co-inhibition by BTLA", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9008059:r:Interleukin-37 signaling", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-CEL-8851805:r:MET activates RAS signaling", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-GGA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-170984:r:ARMS-mediated activation", "R-BTA-8980692:r:RHOA GTPase cycle", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-354192:r:Integrin signaling", "R-HSA-8865999:r:MET activates PTPN11", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-XTR-180292:r:GAB1 signalosome", "R-BTA-8985947:r:Interleukin-9 signaling", "R-BTA-430116:r:GP1b-IX-V activation signalling", "R-HSA-191650:r:Regulation of gap junction activity", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-XTR-210993:r:Tie2 Signaling", "R-MMU-191650:r:Regulation of gap junction activity", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-167044:r:Signalling to RAS", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-CEL-9020956:r:Interleukin-27 signaling", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-74713:r:IRS activation", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-1433559:r:Regulation of KIT signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-SSC-909733:r:Interferon alpha/beta signaling", "R-DME-912631:r:Regulation of signaling by CBL", "R-HSA-2029481:r:FCGR activation", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-DME-210993:r:Tie2 Signaling", "R-BTA-9013409:r:RHOJ GTPase cycle", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-170968:r:Frs2-mediated activation", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-8865999:r:MET activates PTPN11", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-RNO-9748787:r:Azathioprine ADME", "R-DME-5673000:r:RAF activation", "R-CEL-525793:r:Myogenesis", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-DDI-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-XTR-1963642:r:PI3K events in ERBB2 signaling", "R-CEL-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-MMU-373753:r:Nephrin family interactions", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-186763:r:Downstream signal transduction", "R-BTA-354192:r:Integrin signaling", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-DRE-912631:r:Regulation of signaling by CBL", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-RNO-1059683:r:Interleukin-6 signaling", "R-DME-2428933:r:SHC-related events triggered by IGF1R", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-186763:r:Downstream signal transduction", "R-GGA-186763:r:Downstream signal transduction", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-8985947:r:Interleukin-9 signaling", "R-BTA-180336:r:SHC1 events in EGFR signaling", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-8849474:r:PTK6 Activates STAT3", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-BTA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-8866376:r:Reelin signalling pathway", "R-BTA-5621480:r:Dectin-2 family", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-SSC-74751:r:Insulin receptor signalling cascade", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-GGA-8865999:r:MET activates PTPN11", "R-HSA-1489509:r:DAG and IP3 signaling", "R-MMU-210990:r:PECAM1 interactions", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210993:r:Tie2 Signaling", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-GGA-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-DME-209209:r:Formation of the activated receptor complex", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2586552:r:Signaling by Leptin", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-167044:r:Signalling to RAS", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-RNO-5673000:r:RAF activation", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-2424491:r:DAP12 signaling", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-XTR-5654699:r:SHC-mediated cascade:FGFR2", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-GGA-389948:r:Co-inhibition by PD-1", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-445144:r:Signal transduction by L1", "R-BTA-8851805:r:MET activates RAS signaling", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-BTA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-CEL-354192:r:Integrin signaling", "R-DDI-8985947:r:Interleukin-9 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-210671:r:Transcriptional repression by nuclear factors", "R-SSC-2029481:r:FCGR activation", "R-MMU-3928664:r:Ephrin signaling", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DME-8983432:r:Interleukin-15 signaling", "R-BTA-3928664:r:Ephrin signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-GGA-5654712:r:FRS-mediated FGFR4 signaling", "R-DRE-8874081:r:MET activates PTK2 signaling", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-8875656:r:MET receptor recycling", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-RNO-6783783:r:Interleukin-10 signaling", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-XTR-1257604:r:PIP3 activates AKT signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-9013424:r:RHOV GTPase cycle", "R-DME-69231:r:Cyclin D associated events in G1", "R-RNO-8866376:r:Reelin signalling pathway", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9927353:r:Co-inhibition by BTLA", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-BTA-3928663:r:EPHA-mediated growth cone collapse", "R-DME-2424491:r:DAP12 signaling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9748787:r:Azathioprine ADME", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-CFA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-8853659:r:RET signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-177929:r:Signaling by EGFR", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CEL-9833482:r:PKR-mediated signaling", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-CEL-432142:r:Platelet sensitization by LDL", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DRE-210990:r:PECAM1 interactions", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-GGA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-416476:r:G alpha (q) signalling events", "R-SSC-8951664:r:Neddylation", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-418885:r:DCC mediated attractive signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-8875656:r:MET receptor recycling", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-354192:r:Integrin signaling", "R-XTR-8851805:r:MET activates RAS signaling", "R-GGA-2871796:r:FCERI mediated MAPK activation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-CEL-1059683:r:Interleukin-6 signaling", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-432142:r:Platelet sensitization by LDL", "R-RNO-389356:r:Co-stimulation by CD28", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-1433559:r:Regulation of KIT signaling", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-DME-9020591:r:Interleukin-12 signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-DRE-1295596:r:Spry regulation of FGF signaling", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-9008059:r:Interleukin-37 signaling", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SSC-9766229:r:Degradation of CDH1", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-8951664:r:Neddylation", "R-BTA-1227986:r:Signaling by ERBB2", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-CEL-6783783:r:Interleukin-10 signaling", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-XTR-1433557:r:Signaling by SCF-KIT", "R-CEL-182971:r:EGFR downregulation", "R-RNO-416476:r:G alpha (q) signalling events", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-XTR-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-9607240:r:FLT3 Signaling", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-170968:r:Frs2-mediated activation", "R-MMU-9634597:r:GPER1 signaling", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-186763:r:Downstream signal transduction", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-389356:r:Co-stimulation by CD28", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-6783783:r:Interleukin-10 signaling", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-XTR-74749:r:Signal attenuation", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-1227986:r:Signaling by ERBB2", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-DDI-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-GGA-877300:r:Interferon gamma signaling", "R-BTA-9927354:r:Co-stimulation by ICOS", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-MMU-74713:r:IRS activation", "R-RNO-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-8849474:r:PTK6 Activates STAT3", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9013424:r:RHOV GTPase cycle", "R-CEL-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-RNO-3928664:r:Ephrin signaling", "R-DME-74749:r:Signal attenuation", "R-XTR-5654732:r:Negative regulation of FGFR3 signaling", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-9696264:r:RND3 GTPase cycle", "R-RNO-389948:r:Co-inhibition by PD-1", "R-CEL-877312:r:Regulation of IFNG signaling", "R-BTA-210993:r:Tie2 Signaling", "R-XTR-5654689:r:PI-3K cascade:FGFR1", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CEL-6798695:r:Neutrophil degranulation", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8875791:r:MET activates STAT3", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-MMU-8865999:r:MET activates PTPN11", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-MMU-8951664:r:Neddylation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-8866376:r:Reelin signalling pathway", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-BTA-8853659:r:RET signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-BTA-1251985:r:Nuclear signaling by ERBB4", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-XTR-182971:r:EGFR downregulation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-SSC-74749:r:Signal attenuation", "R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-BTA-8854691:r:Interleukin-20 family signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-SSC-6783783:r:Interleukin-10 signaling", "R-DME-525793:r:Myogenesis", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-8854691:r:Interleukin-20 family signaling", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-MMU-198203:r:PI3K/AKT activation", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-BTA-201556:r:Signaling by ALK", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-8849473:r:PTK6 Expression", "R-XTR-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-1306955:r:GRB7 events in ERBB2 signaling", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-SSC-9008059:r:Interleukin-37 signaling", "R-GGA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-SSC-2424491:r:DAP12 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-877312:r:Regulation of IFNG signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-74749:r:Signal attenuation", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-5673000:r:RAF activation", "R-CEL-8849470:r:PTK6 Regulates Cell Cycle", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-877300:r:Interferon gamma signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-MMU-1266695:r:Interleukin-7 signaling", "R-BTA-9696273:r:RND1 GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9833482:r:PKR-mediated signaling", "R-DDI-8984722:r:Interleukin-35 Signalling", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-167021:r:PLC-gamma1 signalling", "R-RNO-9607240:r:FLT3 Signaling", "R-XTR-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-9634597:r:GPER1 signaling", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-DME-74751:r:Insulin receptor signalling cascade", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-DME-3928664:r:Ephrin signaling", "R-SSC-982772:r:Growth hormone receptor signaling", "R-CEL-9008059:r:Interleukin-37 signaling", "R-DME-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-GGA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-BTA-8983432:r:Interleukin-15 signaling", "R-GGA-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8875656:r:MET receptor recycling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8851805:r:MET activates RAS signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-RNO-8951664:r:Neddylation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9842663:r:Signaling by LTK", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-9020956:r:Interleukin-27 signaling", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-1433557:r:Signaling by SCF-KIT"], "type": "Homologous_superfamily"}, "IPR036861": {"description": "Endochitinase-like superfamily", "go_ids": ["GO:0008061"], "go_terms": ["GO:0008061:chitin binding:F"], "name": "Endochitinase-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036862": {"description": "Integrase, C-terminal domain superfamily, retroviral", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "Integrase_C_dom_sf_retrovir", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-HSA-180910", "R-HSA-162592", "R-HSA-177539", "R-HSA-164843", "R-HSA-164516", "R-HSA-175567", "R-HSA-175474", "R-HSA-162585", "R-HSA-162588", "R-HSA-180689", "R-HSA-164525", "R-HSA-173107", "R-HSA-162594"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-173107:r:Binding and entry of HIV virion", "R-HSA-162594:r:Early Phase of HIV Life Cycle"], "type": "Homologous_superfamily"}, "IPR036863": {"description": "Photosystem II reaction centre protein H superfamily", "go_ids": ["GO:0015979", "GO:0050821", "GO:0042301", "GO:0016020", "GO:0009523"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0050821:protein stabilization:P", "GO:0042301:phosphate ion binding:F", "GO:0016020:membrane:C", "GO:0009523:photosystem II:C"], "name": "PSII_PsbH_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036864": {"description": "Zn(2)-C6 fungal-type DNA-binding domain superfamily", "go_ids": ["GO:0006355", "GO:0008270", "GO:0000981"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0008270:zinc ion binding:F", "GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific:F"], "name": "Zn2-C6_fun-type_DNA-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036865": {"description": "CRAL-TRIO lipid binding domain superfamily", "go_ids": [], "go_terms": [], "name": "CRAL-TRIO_dom_sf", "pathway_ids": ["R-RNO-9013026", "R-MMU-416476", "R-HSA-9013409", "R-HSA-9013405", "R-DDI-5218921", "R-MMU-8877627", "R-HSA-6798695", "R-DDI-2187335", "R-RNO-9013409", "R-HSA-8877627", "R-MMU-9013106", "R-MMU-9013408", "R-RNO-9013149", "R-RNO-5687128", "R-MMU-9013409", "R-MMU-9013404", "R-GGA-2187335", "R-RNO-8877627", "R-HSA-3928662", "R-DDI-2453902", "R-DME-9035034", "R-DME-9013148", "R-SCE-8980692", "R-SCE-9013149", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-HSA-2187335", "R-DDI-9013423", "R-RNO-416476", "R-RNO-193648", "R-MMU-9035034", "R-DME-9013149", "R-DME-8980692", "R-RNO-432720", "R-DDI-5658442", "R-HSA-432720", "R-HSA-416482", "R-MMU-2453902", "R-RNO-9013148", "R-RNO-418885", "R-GGA-2453902", "R-HSA-9013404", "R-SCE-9013148", "R-HSA-9008059", "R-HSA-9013149", "R-MMU-9013423", "R-SPO-8980692", "R-HSA-8980692", "R-HSA-9918438", "R-SCE-9035034", "R-HSA-5658442", "R-MMU-9013406", "R-MMU-193648", "R-HSA-9013026", "R-DRE-8980692", "R-MMU-6798695", "R-BTA-2453902", "R-DDI-8877627", "R-MMU-5687128", "R-MMU-2187335", "R-DRE-416482", "R-DRE-9013423", "R-SCE-9013423", "R-MMU-8980692", "R-RNO-8980692", "R-BTA-2187335", "R-DDI-8849471", "R-HSA-9013106", "R-HSA-418885", "R-HSA-416476", "R-MMU-9013148", "R-DRE-9013404", "R-DDI-9013149", "R-HSA-9013423", "R-RNO-416482", "R-SCE-9013406", "R-HSA-9035034", "R-HSA-9013148", "R-RNO-3928662", "R-DRE-9013149", "R-DME-9013406", "R-DME-9013409", "R-MMU-5658442", "R-RNO-9013106", "R-MMU-432720", "R-HSA-6802953", "R-HSA-525793", "R-SCE-9013409", "R-HSA-193648", "R-DRE-9013408", "R-DME-8877627", "R-HSA-9696270", "R-DRE-9013409", "R-DDI-432720", "R-SCE-9013106", "R-RNO-9013423", "R-DRE-9013148", "R-HSA-5687128", "R-RNO-5658442", "R-MMU-416482", "R-MMU-3928662", "R-MMU-9013026", "R-MMU-525793", "R-HSA-9013406", "R-DRE-416476", "R-DRE-193648", "R-MMU-9013149", "R-DDI-9013404", "R-MMU-9696270", "R-DME-9013423", "R-MMU-418885", "R-HSA-2453902"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-8877627:r:Vitamin E transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-2187335:r:The retinoid cycle in cones (daylight vision)", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-8877627:r:Vitamin E transport", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-GGA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-RNO-8877627:r:Vitamin E transport", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-DDI-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DME-9035034:r:RHOF GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-418885:r:DCC mediated attractive signaling", "R-GGA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9918438:r:Defective visual phototransduction due to RDH5 loss of function", "R-SCE-9035034:r:RHOF GTPase cycle", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DDI-8877627:r:Vitamin E transport", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-2187335:r:The retinoid cycle in cones (daylight vision)", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-BTA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants", "R-HSA-525793:r:Myogenesis", "R-SCE-9013409:r:RHOJ GTPase cycle", "R-HSA-193648:r:NRAGE signals death through JNK", "R-DRE-9013408:r:RHOG GTPase cycle", "R-DME-8877627:r:Vitamin E transport", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-525793:r:Myogenesis", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DRE-416476:r:G alpha (q) signalling events", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Homologous_superfamily"}, "IPR036866": {"description": "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like", "go_ids": [], "go_terms": [], "name": "RibonucZ/Hydroxyglut_hydro", "pathway_ids": ["R-CEL-159231", "R-RNO-6807505", "R-HSA-6807505", "R-DME-77595", "R-MMU-9770562", "R-SPO-159231", "R-HSA-1614517", "R-HSA-8868766", "R-MMU-77595", "R-BTA-1614517", "R-HSA-73856", "R-SPO-70268", "R-DME-159231", "R-DDI-9770562", "R-CEL-73856", "R-HSA-72187", "R-DRE-6807505", "R-CEL-77595", "R-DRE-6783310", "R-HSA-77595", "R-DME-9770562", "R-DRE-5693571", "R-RNO-70268", "R-GGA-353303", "R-CEL-9770562", "R-DME-73856", "R-HSA-9918481", "R-MMU-159231", "R-MMU-1614517", "R-BTA-77595", "R-MMU-70268", "R-HSA-2466712", "R-HSA-9770562", "R-SCE-77595", "R-HSA-6784531", "R-MMU-73856", "R-BTA-73856", "R-HSA-9708296", "R-RNO-5693571", "R-SPO-77595", "R-HSA-6783310", "R-MMU-6807505", "R-HSA-70268", "R-BTA-70268", "R-DDI-6807505", "R-GGA-353248", "R-GGA-5693571", "R-SPO-9770562", "R-HSA-9864848", "R-MMU-6783310", "R-DME-6807505", "R-HSA-5693571", "R-MMU-72187", "R-DDI-70268", "R-DDI-77595", "R-DRE-70268", "R-HSA-159231", "R-BTA-9770562", "R-BTA-159231", "R-HSA-6785470", "R-MMU-5693571", "R-RNO-6783310", "R-SCE-70268"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-1614517:r:Sulfide oxidation to sulfate", "R-HSA-8868766:r:rRNA processing in the mitochondrion", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-1614517:r:Sulfide oxidation to sulfate", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-SPO-70268:r:Pyruvate metabolism", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-70268:r:Pyruvate metabolism", "R-GGA-353303:r:Nucleotide Excision Repair", "R-CEL-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-70268:r:Pyruvate metabolism", "R-HSA-2466712:r:Biosynthesis of A2E, implicated in retinal degradation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-353248:r:DNA damage recognition in global genomic repair", "R-GGA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9864848:r:Complex IV assembly", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-72187:r:mRNA 3'-end processing", "R-DDI-70268:r:Pyruvate metabolism", "R-DDI-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-70268:r:Pyruvate metabolism", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-6785470:r:tRNA processing in the mitochondrion", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Homologous_superfamily"}, "IPR036867": {"description": "R3H domain superfamily", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "R3H_dom_sf", "pathway_ids": ["R-MMU-9930044", "R-MMU-450604", "R-HSA-380994", "R-HSA-9930044", "R-MMU-429947", "R-DRE-450604", "R-HSA-429947", "R-HSA-450604"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-HSA-9930044:r:Nuclear RNA decay", "R-MMU-429947:r:Deadenylation of mRNA", "R-DRE-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA"], "type": "Homologous_superfamily"}, "IPR036868": {"description": "TusA-like domain superfamily", "go_ids": [], "go_terms": [], "name": "TusA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036869": {"description": "Chaperone J-domain superfamily", "go_ids": [], "go_terms": [], "name": "J_dom_sf", "pathway_ids": ["R-SCE-3371453", "R-HSA-6798695", "R-MMU-8856828", "R-HSA-1362409", "R-HSA-9833482", "R-BTA-3371568", "R-HSA-8856828", "R-SPO-3371571", "R-MMU-9770562", "R-HSA-6799198", "R-HSA-9918487", "R-SCE-9841251", "R-BTA-6798695", "R-MMU-8957275", "R-MMU-9833482", "R-HSA-3371453", "R-HSA-9662360", "R-HSA-1268020", "R-MMU-381426", "R-MMU-1268020", "R-SCE-1268020", "R-HSA-381426", "R-RNO-432722", "R-DDI-6798695", "R-HSA-9865881", "R-BTA-3371453", "R-MMU-6799198", "R-HSA-432720", "R-HSA-9918432", "R-BTA-5687128", "R-BTA-3371571", "R-BTA-888590", "R-SCE-9865881", "R-DRE-3371453", "R-SPO-1268020", "R-HSA-8949613", "R-RNO-381426", "R-HSA-72163", "R-MMU-3371568", "R-MMU-5358493", "R-MMU-9841251", "R-SPO-9841251", "R-MMU-6798695", "R-BTA-3371497", "R-MMU-5687128", "R-MMU-3371497", "R-RNO-6798695", "R-SCE-3371497", "R-SPO-3371453", "R-RNO-3371453", "R-MMU-432722", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-RNO-9841251", "R-SCE-3371568", "R-HSA-192823", "R-MMU-9865881", "R-DME-888590", "R-RNO-8957275", "R-MMU-1362409", "R-RNO-8856828", "R-MMU-432720", "R-HSA-432722", "R-HSA-9918481", "R-HSA-3371568", "R-SCE-3371571", "R-MMU-3371453", "R-DDI-9833482", "R-HSA-381038", "R-HSA-9770562", "R-SPO-3371568", "R-SCE-1362409", "R-DDI-3371453", "R-DME-6798695", "R-MMU-888590", "R-HSA-9841251", "R-XTR-3371453", "R-MMU-3371571", "R-SPO-3371497", "R-HSA-888590", "R-SPO-9865881", "R-HSA-5687128", "R-DDI-3371497", "R-RNO-9770562", "R-HSA-3371571", "R-HSA-5358493", "R-HSA-8957275", "R-BTA-9841251", "R-RNO-888590", "R-RNO-9833482", "R-SPO-1362409"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9833482:r:PKR-mediated signaling", "R-BTA-3371568:r:Attenuation phase", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SPO-3371571:r:HSF1-dependent transactivation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-6799198:r:Complex I biogenesis", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1268020:r:Mitochondrial protein import", "R-SCE-1268020:r:Mitochondrial protein import", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9865881:r:Complex III assembly", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-SCE-9865881:r:Complex III assembly", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-1268020:r:Mitochondrial protein import", "R-HSA-8949613:r:Cristae formation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-3371568:r:Attenuation phase", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-6798695:r:Neutrophil degranulation", "R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SCE-3371568:r:Attenuation phase", "R-HSA-192823:r:Viral mRNA Translation", "R-MMU-9865881:r:Complex III assembly", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-3371568:r:Attenuation phase", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DDI-9833482:r:PKR-mediated signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-SPO-3371568:r:Attenuation phase", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DDI-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-SPO-9865881:r:Complex III assembly", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-9833482:r:PKR-mediated signaling", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis"], "type": "Homologous_superfamily"}, "IPR036870": {"description": "Small ribosomal subunit protein bS18 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_bS18_sf", "pathway_ids": ["R-BTA-5389840", "R-SSC-9937383", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-SSC-5419276", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-SSC-5389840", "R-MMU-5389840", "R-HSA-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-SSC-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-SSC-5419276:r:Mitochondrial translation termination", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-SSC-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Homologous_superfamily"}, "IPR036871": {"description": "PX domain superfamily", "go_ids": ["GO:0035091"], "go_terms": ["GO:0035091:phosphatidylinositol binding:F"], "name": "PX_dom_sf", "pathway_ids": ["R-RNO-1236973", "R-HSA-9013405", "R-HSA-9013409", "R-MMU-1222556", "R-HSA-6798695", "R-MMU-8856828", "R-RNO-1483166", "R-MMU-1660516", "R-HSA-8856828", "R-CEL-1660514", "R-HSA-5689880", "R-SCE-2029485", "R-MMU-9013106", "R-MMU-9013408", "R-CEL-432722", "R-RNO-9013149", "R-RNO-3238698", "R-MMU-9013409", "R-MMU-9013404", "R-MMU-4420097", "R-DRE-8941237", "R-SPO-3238698", "R-RNO-3299685", "R-HSA-4420097", "R-MMU-5689880", "R-HSA-6811434", "R-RNO-2029485", "R-SCE-8980692", "R-SCE-9013149", "R-SPO-5668599", "R-MMU-5668599", "R-MMU-1660514", "R-MMU-2029485", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-9013408", "R-RNO-432722", "R-MMU-6811434", "R-MMU-9035034", "R-HSA-3299685", "R-HSA-3238698", "R-HSA-1236973", "R-MMU-3299685", "R-HSA-1660516", "R-RNO-5689880", "R-HSA-9696264", "R-HSA-9013404", "R-SCE-9013148", "R-MMU-9013423", "R-HSA-9013149", "R-MMU-1483166", "R-HSA-8980692", "R-SCE-9035034", "R-MMU-9013406", "R-HSA-8941237", "R-RNO-9696264", "R-HSA-9013026", "R-CEL-1660517", "R-MMU-6798695", "R-MMU-9696264", "R-HSA-9768727", "R-MMU-1660517", "R-MMU-9768727", "R-RNO-4420097", "R-RNO-6798695", "R-CEL-1660516", "R-HSA-1660517", "R-SCE-9013423", "R-MMU-3238698", "R-RNO-9696270", "R-MMU-8980692", "R-RNO-8980692", "R-SCE-6798695", "R-MMU-432722", "R-MMU-983189", "R-HSA-2029485", "R-HSA-2672351", "R-HSA-9013106", "R-MMU-9013148", "R-RNO-1222556", "R-RNO-1660514", "R-HSA-1660499", "R-HSA-1483166", "R-HSA-1483148", "R-SPO-8941237", "R-RNO-5668599", "R-HSA-9013423", "R-BTA-3238698", "R-RNO-2672351", "R-HSA-1222556", "R-MMU-8941237", "R-MMU-2672351", "R-HSA-9035034", "R-HSA-9013148", "R-SCE-9013424", "R-HSA-432722", "R-CEL-8856828", "R-HSA-9696270", "R-SCE-3238698", "R-HSA-1660514", "R-HSA-9673324", "R-MMU-1236973", "R-MMU-1660499", "R-RNO-9013423", "R-DRE-9013148", "R-RNO-1660499", "R-HSA-983189", "R-MMU-9013026", "R-CEL-1660499", "R-BTA-432722", "R-MMU-9696270", "R-HSA-9013406", "R-SCE-5668599", "R-MMU-9013149", "R-SCE-1483166", "R-HSA-5668599"], "pathways": ["R-RNO-1236973:r:Cross-presentation of particulate exogenous antigens 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"R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-9035034:r:RHOF GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-8941237:r:Invadopodia formation", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SCE-9013423:r:RAC3 GTPase cycle", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-983189:r:Kinesins", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1483166:r:Synthesis of PA", "R-HSA-1483148:r:Synthesis of PG", "R-SPO-8941237:r:Invadopodia formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-BTA-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-MMU-8941237:r:Invadopodia formation", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SCE-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-983189:r:Kinesins", "R-MMU-9013026:r:RHOB GTPase cycle", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-SCE-1483166:r:Synthesis of PA", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases"], "type": "Homologous_superfamily"}, "IPR036872": {"description": "CH domain superfamily", "go_ids": [], "go_terms": [], "name": "CH_dom_sf", "pathway_ids": ["R-HSA-9013405", "R-HSA-6802952", "R-MMU-6811558", "R-GGA-446388", "R-BTA-5673001", "R-HSA-2871796", "R-HSA-912631", "R-MMU-3928665", "R-HSA-8951664", "R-RNO-446388", "R-MMU-68877", "R-HSA-9027284", "R-RNO-512988", "R-RNO-2871809", "R-RNO-5218920", 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"R-RNO-6811558", "R-BTA-2565942", "R-HSA-389359", "R-RNO-380284", "R-MMU-5620912", "R-HSA-446107", "R-DDI-445144", "R-MMU-5673001", "R-HSA-114604", "R-SPO-5626467", "R-GGA-9013420", "R-DME-9013149", "R-HSA-182971", "R-HSA-2424491", "R-DME-114608", "R-DME-5627123", "R-HSA-983231", "R-HSA-416482", "R-HSA-141444", "R-MMU-380270", "R-HSA-9696264", "R-MMU-9013423", "R-HSA-2022090", "R-DME-1257604", "R-DME-416482", "R-MMU-193648", "R-HSA-9013026", "R-HSA-445144", "R-MMU-5627123", "R-HSA-264870", "R-MMU-5663220", "R-MMU-446107", "R-HSA-9656223", "R-BTA-2029482", "R-DME-5673001", "R-HSA-2467813", "R-HSA-445095", "R-MMU-430116", "R-RNO-9035034", "R-MMU-8980692", "R-MMU-8852276", "R-SCE-6798695", "R-HSA-9013106", "R-MMU-380284", "R-RNO-9027284", "R-DME-1433557", "R-SPO-9013406", "R-HSA-9013423", "R-HSA-68877", "R-MMU-512988", "R-SPO-9013420", "R-GGA-193648", "R-MMU-9027284", "R-BTA-1433557", "R-BTA-512988", "R-CEL-193648", "R-CEL-9013423", "R-DDI-2029482", "R-MMU-3928664", "R-RNO-68877", "R-MMU-912631", "R-RNO-446107", "R-MMU-5626467", "R-DDI-5687128", "R-DDI-392517", "R-HSA-9913351", "R-GGA-114608", "R-HSA-380270", "R-XTR-8852276", "R-SCE-9013106", "R-RNO-380259", "R-CEL-3928665", "R-DDI-3928662", "R-BTA-9013404", "R-MMU-264870", "R-BTA-1257604", "R-DME-6803207", "R-HSA-5663220", "R-HSA-446388", "R-BTA-9027284", "R-DDI-9013404", "R-MMU-9013149", "R-XTR-8854518", "R-DME-9013420", "R-SPO-6807878", "R-DDI-354192", "R-MMU-446353", "R-MMU-389359", "R-MMU-182971", "R-HSA-5674135", "R-DME-375165", "R-HSA-430116", "R-DME-114604", "R-CEL-912631", "R-HSA-380284", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-8854518", "R-CEL-416482", "R-MMU-446388", "R-BTA-9035034", "R-BTA-380259", "R-HSA-4420097", "R-SPO-9013106", "R-MMU-2871796", "R-DME-9035034", "R-HSA-380320", "R-DME-2424491", "R-BTA-2871809", "R-HSA-9649948", "R-SCE-9013420", "R-BTA-9013418", "R-CEL-9013148", "R-DME-438066", "R-DDI-193648", "R-MMU-9748787", "R-DME-445095", "R-DME-8980692", "R-MMU-438066", "R-MMU-390522", "R-HSA-8950505", "R-HSA-2219530", "R-HSA-9648025", "R-BTA-912631", "R-MMU-445144", "R-GGA-9013418", "R-RNO-8964616", "R-CEL-446353", "R-BTA-390522", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-DME-445144", "R-MMU-9913351", "R-HSA-9620244", "R-HSA-381676", "R-SPO-9013424", "R-BTA-114604", "R-RNO-4420097", "R-MMU-375165", "R-HSA-5626467", "R-HSA-5368598", "R-HSA-9619665", "R-XTR-380270", "R-HSA-1169408", "R-RNO-5620912", "R-DDI-9013149", "R-CEL-9013149", "R-DME-6811558", "R-BTA-114608", "R-BTA-2467813", "R-DDI-381676", "R-XTR-5620912", "R-SCE-9013406", "R-HSA-6802946", "R-DME-2871809", "R-BTA-2871796", "R-HSA-9619229", "R-MMU-446343", "R-HSA-5620912", "R-MMU-9648025", "R-BTA-380284", "R-HSA-193648", "R-HSA-9013420", "R-DDI-171007", "R-CEL-9913351", "R-RNO-6807878", "R-HSA-8964616", "R-HSA-9662361", "R-HSA-6807878", "R-HSA-8852276", "R-HSA-9679191", "R-MMU-983695", "R-HSA-1433557", "R-XTR-68877", "R-DME-9013418", "R-RNO-9913351", "R-DDI-5621575", "R-RNO-114604", "R-HSA-9703465", "R-BTA-9013408", "R-GGA-8964616", "R-BTA-8854518", "R-BTA-380270", "R-MMU-2871809", "R-MMU-9013026", "R-XTR-2565942", "R-MMU-2424491", "R-RNO-264870", "R-MMU-9696270", "R-DME-4420097", "R-BTA-141444", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-8951664:r:Neddylation", "R-RNO-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-912631:r:Regulation of signaling by CBL", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-GGA-416482:r:G alpha (12/13) signalling events", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-SCE-8980692:r:RHOA GTPase cycle", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-RNO-193648:r:NRAGE signals death through JNK", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-DME-193648:r:NRAGE signals death through JNK", "R-CEL-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-SCE-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-114608:r:Platelet degranulation", "R-CEL-9748787:r:Azathioprine ADME", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-8983711:r:OAS antiviral response", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", 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"R-HSA-177539:r:Autointegration results in viral DNA circles", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-XTR-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-162592:r:Integration of provirus", "R-XTR-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Homologous_superfamily"}, "IPR036876": {"description": "UVR domain superfamily", "go_ids": [], "go_terms": [], "name": "UVR_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036877": {"description": "SUI1 domain superfamily", "go_ids": ["GO:0006413", "GO:0003743"], "go_terms": ["GO:0006413:translational initiation:P", "GO:0003743:translation initiation factor activity:F"], "name": "SUI1_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036878": {"description": "Glucose permease domain IIB", "go_ids": ["GO:0009401", "GO:0008982"], "go_terms": ["GO:0009401:phosphoenolpyruvate-dependent sugar phosphotransferase system:P", "GO:0008982:protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity:F"], "name": "Glu_permease_IIB", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036879": {"description": "Transcription factor, MADS-box superfamily", "go_ids": ["GO:0003677", "GO:0046983"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0046983:protein dimerization activity:F"], "name": "TF_MADSbox_sf", "pathway_ids": ["R-HSA-198753", "R-SPO-9031628", "R-HSA-2151201", "R-HSA-9768777", "R-HSA-9707616", "R-DME-525793", "R-HSA-9931509", "R-HSA-9634638", "R-MMU-9031628", "R-CEL-525793", "R-RNO-525793", "R-BTA-525793", "R-SCE-525793", "R-HSA-9733709", "R-DDI-525793", "R-HSA-5663220", "R-MMU-525793", "R-DME-5663220", "R-HSA-9031628", "R-DDI-9031628", "R-CEL-9031628", "R-HSA-525793", "R-SPO-525793", "R-MMU-5663220", "R-SCE-9031628", "R-HSA-9022707"], "pathways": ["R-HSA-198753:r:ERK/MAPK targets", "R-SPO-9031628:r:NGF-stimulated transcription", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9768777:r:Regulation of NPAS4 gene transcription", "R-HSA-9707616:r:Heme signaling", "R-DME-525793:r:Myogenesis", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-9031628:r:NGF-stimulated transcription", "R-CEL-525793:r:Myogenesis", "R-RNO-525793:r:Myogenesis", "R-BTA-525793:r:Myogenesis", "R-SCE-525793:r:Myogenesis", "R-HSA-9733709:r:Cardiogenesis", "R-DDI-525793:r:Myogenesis", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-525793:r:Myogenesis", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-HSA-9031628:r:NGF-stimulated transcription", "R-DDI-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-525793:r:Myogenesis", "R-SPO-525793:r:Myogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-SCE-9031628:r:NGF-stimulated transcription", "R-HSA-9022707:r:MECP2 regulates transcription factors"], "type": "Homologous_superfamily"}, "IPR036880": {"description": "Pancreatic trypsin inhibitor Kunitz domain superfamily", "go_ids": ["GO:0004867"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F"], "name": "Kunitz_BPTI_sf", "pathway_ids": ["R-HSA-186797", "R-MMU-416476", "R-SSC-432720", "R-MMU-204005", "R-HSA-879415", "R-HSA-3000178", "R-MMU-5694530", "R-HSA-2168880", "R-RNO-444473", "R-MMU-933542", "R-MMU-8957275", "R-HSA-5694530", "R-HSA-1650814", "R-MMU-2214320", "R-HSA-6806942", "R-MMU-445989", "R-MMU-3000178", "R-MMU-381426", "R-HSA-6803157", "R-HSA-8948216", "R-HSA-9609523", "R-SSC-445989", "R-RNO-416476", "R-RNO-3000178", "R-MMU-2168880", "R-HSA-381426", "R-SSC-3000178", "R-SSC-381426", "R-RNO-6803157", "R-RNO-432720", "R-HSA-432720", "R-RNO-2168880", "R-HSA-9660826", "R-SSC-9609523", "R-HSA-419037", "R-RNO-381426", "R-HSA-204005", "R-HSA-2022090", "R-RNO-879415", "R-RNO-445989", "R-MMU-216083", "R-HSA-140834", "R-RNO-933542", "R-MMU-114608", "R-HSA-844456", "R-HSA-445989", "R-MMU-9837999", "R-MMU-444473", "R-HSA-3000157", "R-MMU-8948216", "R-HSA-933542", "R-HSA-977225", "R-MMU-140834", "R-SSC-114608", "R-HSA-8862803", "R-HSA-416476", "R-RNO-9609523", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-MMU-8852405", "R-RNO-8957275", "R-SSC-933542", "R-RNO-140834", "R-HSA-444473", "R-HSA-9837999", "R-MMU-432720", "R-MMU-9609523", "R-MMU-6803157", "R-HSA-1442490", "R-HSA-9925563", "R-HSA-2214320", "R-HSA-8852405", "R-HSA-216083", "R-MMU-1566977", "R-SSC-8957275", "R-HSA-1566977", "R-MMU-879415", "R-RNO-9837999", "R-SSC-879415", "R-HSA-418594", "R-MMU-6806942", "R-MMU-1650814", "R-SSC-9837999", "R-HSA-8957275", "R-MMU-1442490"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2214320:r:Anchoring fibril formation", "R-HSA-6806942:r:MET Receptor Activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-3000178:r:ECM proteoglycans", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-HSA-8948216:r:Collagen chain trimerization", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-3000178:r:ECM proteoglycans", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6803157:r:Antimicrobial peptides", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-SSC-114608:r:Platelet degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8852405:r:Signaling by MST1", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-140834:r:Extrinsic Pathway of Fibrin Clot Formation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-1442490:r:Collagen degradation", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8852405:r:Signaling by MST1", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-HSA-1566977:r:Fibronectin matrix formation", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-6806942:r:MET Receptor Activation", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1442490:r:Collagen degradation"], "type": "Homologous_superfamily"}, "IPR036881": {"description": "Glycoside hydrolase family 3 C-terminal domain superfamily", "go_ids": ["GO:0005975", "GO:0004553"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "Glyco_hydro_3_C_sf", "pathway_ids": ["PWY-3121", "PWY-6788", "PWY-7091", "PWY-7913", "PWY-7092", "PWY-5176", "PWY-6002"], "pathways": ["PWY-3121:t:linamarin degradation", "PWY-6788:t:cellulose degradation II (fungi)", "PWY-7091:t:linustatin bioactivation", "PWY-7913:t:firefly bioluminescence", "PWY-7092:t:neolinustatin bioactivation", "PWY-5176:t:coumarin biosynthesis (via 2-coumarate)", "PWY-6002:t:lotaustralin degradation"], "type": "Homologous_superfamily"}, "IPR036882": {"description": "Alba-like domain superfamily", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "Alba-like_dom_sf", "pathway_ids": ["R-MMU-6791226", "R-HSA-6784531", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Homologous_superfamily"}, "IPR036883": {"description": "PDCD5-like superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "PDCD5-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036884": {"description": "[2Fe-2S]-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "2Fe-2S-bd_dom_sf", "pathway_ids": ["R-MMU-9748787", "R-RNO-8851680", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", "R-RNO-74259", "R-GGA-421178", "R-DME-964975", "R-MMU-8851680", "R-HSA-9748787", "R-HSA-74259", "R-RNO-964975", "R-DME-74259", "R-MMU-964975", "R-CEL-964975", "R-DME-9748787", "R-MMU-74259", "R-DDI-964975", "R-RNO-9748787", "R-DDI-74259"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-GGA-421178:r:Urate synthesis", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-74259:r:Purine catabolism", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Homologous_superfamily"}, "IPR036885": {"description": "SWIB/MDM2 domain superfamily", "go_ids": [], "go_terms": [], "name": "SWIB_MDM2_dom_sf", "pathway_ids": ["R-HSA-1989781", "R-DME-9933947", "R-MMU-9933946", "R-HSA-2151201", "R-HSA-2559580", "R-DRE-3232142", "R-MMU-8941858", "R-HSA-5689880", "R-RNO-3214858", "R-DRE-69541", "R-MMU-198323", "R-MMU-6804756", "R-HSA-9766229", "R-DRE-2559585", "R-BTA-9933946", "R-MMU-69541", "R-DRE-8941858", "R-DRE-198323", "R-RNO-8939243", "R-HSA-1368108", "R-CFA-69541", "R-MMU-5689880", "R-DME-9933939", "R-CFA-2559585", "R-HSA-6804757", "R-HSA-9933387", "R-HSA-9707564", "R-SPO-9933946", "R-DDI-9933939", "R-DME-400206", "R-MMU-6804760", "R-DRE-6804756", "R-MMU-9934037", "R-HSA-5674400", "R-CEL-9933937", "R-HSA-8941858", "R-HSA-9933947", "R-DDI-3214858", "R-RNO-9934037", "R-HSA-6804760", "R-RNO-9933947", "R-MMU-2559580", "R-RNO-6804760", "R-RNO-5689880", "R-HSA-3232142", "R-MMU-9933939", "R-RNO-6804757", "R-DRE-9766229", "R-HSA-8939243", "R-HSA-6804756", "R-HSA-9933937", "R-CFA-399719", "R-BTA-8939243", "R-HSA-3232118", "R-HSA-400206", "R-CFA-2559580", "R-MMU-9766229", "R-DRE-6804757", "R-MMU-400206", "R-SPO-9933939", "R-HSA-9768919", "R-RNO-2559585", "R-CEL-9933947", "R-DME-8939243", "R-DME-9933946", "R-MMU-3232142", "R-DDI-9933937", "R-DRE-2559580", "R-CFA-6804757", "R-DDI-9933946", "R-HSA-2559585", "R-MMU-9933937", "R-CFA-8941858", "R-CEL-9934037", "R-DME-9934037", "R-HSA-3214858", "R-HSA-9934037", "R-RNO-69541", "R-HSA-198323", "R-BTA-3214858", "R-CFA-5689880", "R-DME-3214858", 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"R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SCE-3371511:r:HSF1 activation"], "type": "Homologous_superfamily"}, "IPR036891": {"description": "Signal recognition particle, SRP54 subunit, M-domain superfamily", "go_ids": ["GO:0006614", "GO:0008312", "GO:0048500"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P", "GO:0008312:7S RNA binding:F", "GO:0048500:signal recognition particle:C"], "name": "Signal_recog_part_SRP54_M_sf", "pathway_ids": ["R-HSA-1799339", "R-DRE-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-RNO-1799339", "R-BTA-1799339", "R-MMU-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", 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"R-HSA-9705677", "R-HSA-447038", "R-RNO-5673001", "R-DME-438066", "R-MMU-5673001", "R-HSA-373753", "R-HSA-451308", "R-MMU-8849932", "R-MMU-438066", "R-XTR-9013408", "R-RNO-438066", "R-HSA-5673001", "R-HSA-9013404", "R-DRE-8849932", "R-MMU-9013423", "R-HSA-9013149", "R-XTR-9013404", "R-HSA-9620244", "R-MMU-9013406", "R-CFA-399719", "R-RNO-6794361", "R-RNO-8849932", "R-HSA-9609736", "R-HSA-212676", "R-DME-5625900", "R-DRE-9013423", "R-CEL-8849932", "R-DRE-438066", "R-BTA-9013406", "R-DRE-9013404", "R-HSA-8849932", "R-HSA-6794361", "R-BTA-9013423", "R-HSA-9013423", "R-CEL-5625900", "R-RNO-5666185", "R-BTA-212676", "R-XTR-9013423", "R-DRE-9013149", "R-HSA-9692912", "R-RNO-451308", "R-HSA-9617324", "R-MMU-5666185", "R-BTA-5666185", "R-DRE-9013408", "R-HSA-399719", "R-XTR-8849932", "R-MMU-212676", "R-CEL-6794361", "R-HSA-3000170", "R-HSA-5666185", "R-HSA-9662361", "R-MMU-6794361", "R-RNO-399719", "R-DME-212676", "R-DME-451308", "R-RNO-9013423", "R-BTA-9013408", "R-DME-8849932", "R-HSA-438066", "R-XTR-9013406", "R-BTA-9013404", "R-XTR-438066", "R-DME-6794361", "R-CFA-438066", "R-HSA-9013406", "R-MMU-9013149", "R-MMU-399719"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-420029:r:Tight junction interactions", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CFA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-CFA-8849932:r:Synaptic adhesion-like molecules", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-HSA-447038:r:NrCAM interactions", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-451308:r:Activation of Ca-permeable Kainate Receptor", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-XTR-9013408:r:RHOG GTPase cycle", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-HSA-9620244:r:Long-term potentiation", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-CFA-399719:r:Trafficking of AMPA receptors", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-5625900:r:RHO GTPases activate CIT", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-DRE-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-6794361:r:Neurexins and neuroligins", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-5625900:r:RHO GTPases activate CIT", "R-RNO-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9692912:r:SARS-CoV-1 targets PDZ proteins in cell-cell junction", "R-RNO-451308:r:Activation of Ca-permeable Kainate Receptor", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DRE-9013408:r:RHOG GTPase cycle", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-XTR-8849932:r:Synaptic adhesion-like molecules", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-6794361:r:Neurexins and neuroligins", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-6794361:r:Neurexins and neuroligins", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-451308:r:Activation of Ca-permeable Kainate Receptor", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-DME-8849932:r:Synaptic adhesion-like molecules", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-XTR-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-DME-6794361:r:Neurexins and neuroligins", "R-CFA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors"], "type": "Homologous_superfamily"}, "IPR036893": {"description": "SBP domain superfamily", "go_ids": ["GO:0003677", "GO:0005634"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C"], "name": "SBP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036894": {"description": "Nucleoid-associated protein YbaB-like domain superfamily", "go_ids": [], "go_terms": [], "name": "YbaB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036895": {"description": "Uracil-DNA glycosylase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Uracil-DNA_glycosylase-like_sf", "pathway_ids": ["R-SPO-3108214", "R-HSA-110357", "R-HSA-3108214", "R-HSA-110328", "R-MMU-5221030", "R-DDI-110329", "R-SCE-110329", "R-HSA-9609690", "R-RNO-110357", "R-BTA-110329", "R-BTA-110357", "R-HSA-9821002", "R-SPO-110329", "R-HSA-5221030", "R-HSA-110329", "R-MMU-110329", "R-MMU-3108214", "R-DDI-110357", "R-MMU-110357", "R-RNO-110329", "R-SPO-5221030"], "pathways": ["R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-MMU-5221030:r:TET1,2,3 and TDG demethylate DNA", "R-DDI-110329:r:Cleavage of the damaged pyrimidine", "R-SCE-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-BTA-110329:r:Cleavage of the damaged pyrimidine", "R-BTA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-SPO-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-5221030:r:TET1,2,3 and TDG demethylate DNA", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-RNO-110329:r:Cleavage of the damaged pyrimidine", "R-SPO-5221030:r:TET1,2,3 and TDG demethylate DNA"], "type": "Homologous_superfamily"}, "IPR036896": {"description": "Avidin-like superfamily", "go_ids": [], "go_terms": [], "name": "Avidin-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036897": {"description": "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "CarbamoylP_synth_lsu_oligo_sf", "pathway_ids": ["PWY-7400", "PWY-4984", "PWY-7791", "PWY-5686", "PWY-7790", "PWY-5154", "R-MMU-500753", "R-MMU-70635", "R-SPO-70635", "R-DME-500753", "R-HSA-500753", "R-SCE-500753", "R-SPO-500753", "R-CEL-500753", "R-HSA-70635", "R-DDI-500753", "R-HSA-9955542", "R-SCE-70635", "R-RNO-70635"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-4984:t:urea cycle", "PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-MMU-500753:r:Pyrimidine biosynthesis", "R-MMU-70635:r:Urea cycle", "R-SPO-70635:r:Urea cycle", "R-DME-500753:r:Pyrimidine biosynthesis", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-SCE-500753:r:Pyrimidine biosynthesis", "R-SPO-500753:r:Pyrimidine biosynthesis", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-HSA-70635:r:Urea cycle", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-HSA-9955542:r:CPS1 variants cause CPS1 deficiency", "R-SCE-70635:r:Urea cycle", "R-RNO-70635:r:Urea cycle"], "type": "Homologous_superfamily"}, "IPR036898": {"description": "RNA polymerase Rpb7-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RNA_pol_Rpb7-like_N_sf", "pathway_ids": ["R-RNO-6781823", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-MMU-9770562", "R-RNO-73779", "R-HSA-73980", "R-HSA-427413", "R-DDI-73776", "R-RNO-72163", "R-DDI-6782210", "R-SPO-6781823", "R-DDI-72163", "R-HSA-167158", "R-MMU-75955", "R-RNO-9018519", "R-RNO-73776", "R-MMU-112382", "R-BTA-9018519", "R-DRE-75955", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-DDI-674695", "R-MMU-76061", "R-HSA-76061", "R-SPO-6796648", "R-HSA-749476", "R-SCE-76061", "R-BTA-72163", "R-BTA-75955", "R-DRE-6782210", "R-BTA-75953", "R-SPO-9018519", "R-SPO-76066", "R-MMU-72163", "R-BTA-6782135", "R-HSA-6803529", "R-HSA-167242", "R-HSA-8851708", "R-HSA-167161", "R-HSA-72163", "R-HSA-9670095", "R-HSA-167160", "R-DDI-77075", "R-DRE-6803529", "R-SPO-73779", "R-DDI-113418", "R-MMU-72086", "R-BTA-6782210", "R-MMU-73772", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-BTA-5578749", "R-DRE-72163", "R-MMU-6781823", "R-BTA-6781823", "R-HSA-203927", "R-DDI-73772", "R-DRE-9770562", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-MMU-73776", "R-DDI-76042", "R-HSA-73780", "R-HSA-167172", "R-DRE-6781823", "R-BTA-73779", "R-SCE-73779", "R-RNO-113418", "R-HSA-76071", "R-HSA-72203", "R-MMU-6796648", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-RNO-6796648", "R-RNO-75955", "R-DRE-73772", "R-SCE-6781823", "R-MMU-76071", "R-DRE-73776", "R-BTA-674695", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-73863", "R-HSA-167290", "R-SPO-73772", "R-RNO-77075", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-DRE-6782135", "R-RNO-9770562", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-SPO-72163", "R-BTA-6807505", "R-BTA-72203", "R-HSA-112382", "R-HSA-73779", "R-DRE-72165", "R-MMU-72203", "R-RNO-6807505", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-RNO-674695", "R-DRE-73779", "R-BTA-76042", "R-SPO-6807505", "R-MMU-76066", "R-DRE-75953", "R-HSA-6796648", "R-HSA-6781823", "R-DRE-6807505", "R-HSA-167287", "R-HSA-167246", "R-DRE-6796648", "R-DRE-113418", "R-RNO-72165", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-DDI-73762", "R-HSA-9018519", "R-MMU-76042", "R-DRE-9018519", "R-SPO-75953", "R-SPO-73762", "R-HSA-5601884", "R-RNO-6782210", "R-SPO-113418", "R-MMU-5250924", "R-DDI-73779", "R-RNO-72203", "R-RNO-76042", "R-BTA-72086", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-MMU-674695", "R-MMU-6807505", "R-DRE-5250924", "R-SCE-76042", "R-MMU-9018519", "R-RNO-5578749", "R-DDI-6807505", "R-SPO-9770562", "R-HSA-167200", "R-SCE-73762", "R-RNO-112382", "R-SCE-674695", "R-BTA-9770562", "R-MMU-6782210", "R-RNO-75953", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-SCE-76066", "R-MMU-73762", "R-MMU-6782135", "R-BTA-113418", "R-HSA-76066", "R-HSA-72086", "R-DDI-9770562", "R-DRE-73762", "R-HSA-167162", "R-DRE-77075", "R-DRE-73863", "R-DDI-76061", "R-HSA-167152", "R-HSA-113418", "R-HSA-1834949", "R-BTA-112382", "R-SCE-6782210", "R-HSA-9918481", "R-RNO-6803529", "R-BTA-6796648", "R-SPO-72203", "R-SCE-72203", "R-SCE-6796648", "R-RNO-72086", "R-SPO-77075", "R-DRE-76042", "R-SCE-113418", "R-SCE-72086", "R-RNO-6782135", "R-MMU-73863", "R-DRE-72203", "R-DRE-72086", "R-HSA-6782135", "R-HSA-73762", "R-DRE-674695", "R-SCE-77075", "R-HSA-5250924", "R-DDI-75953", "R-SPO-6782135"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", 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"R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Homologous_superfamily"}, "IPR036900": {"description": "Alpha-D-phosphohexomutase, C-terminal domain superfamily", "go_ids": ["GO:0016868"], "go_terms": ["GO:0016868:intramolecular phosphotransferase activity:F"], "name": "A-D-PHexomutase_C_sf", "pathway_ids": ["PWY-6749", "R-MMU-70221", "R-HSA-6798695", "R-MMU-71336", "R-SPO-6798695", "R-MMU-70171", "R-HSA-71336", "R-MMU-3322077", "R-DME-70221", "R-DDI-71336", "R-SCE-6798695", "R-SPO-446210", "R-SCE-71336", "R-HSA-446210", "R-SCE-70221", "R-SPO-70221", "R-HSA-3322077", "R-MMU-446210", "R-DDI-70370", "R-RNO-3322077", 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"R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-SPO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-3322077:r:Glycogen synthesis", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-DDI-70370:r:Galactose catabolism", "R-RNO-3322077:r:Glycogen synthesis", "R-HSA-70171:r:Glycolysis", "R-SPO-71336:r:Pentose phosphate pathway", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-SPO-3322077:r:Glycogen synthesis", "R-SCE-70171:r:Glycolysis", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SPO-70171:r:Glycolysis", "R-SCE-3322077:r:Glycogen synthesis", "R-DDI-70171:r:Glycolysis", "R-SPO-70370:r:Galactose catabolism", "R-SCE-70370:r:Galactose catabolism", "R-DDI-3322077:r:Glycogen synthesis", "R-MMU-70370:r:Galactose catabolism", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-SSC-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-70370:r:Galactose catabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5609974:r:Defective PGM1 causes PGM1-CDG", "R-RNO-70370:r:Galactose catabolism", "R-DME-70370:r:Galactose catabolism", "R-DME-3322077:r:Glycogen synthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-70221:r:Glycogen breakdown (glycogenolysis)"], "type": "Homologous_superfamily"}, "IPR036901": {"description": "Aspartate/ornithine carbamoyltransferase superfamily", "go_ids": ["GO:0006520", "GO:0016597", "GO:0016743"], "go_terms": ["GO:0006520:amino acid metabolic process:P", "GO:0016597:amino acid binding:F", "GO:0016743:carboxyl- or carbamoyltransferase activity:F"], "name": "Asp/Orn_carbamoylTrfase_sf", "pathway_ids": ["PWY-7791", "PWY-5686", "PWY-7790", "R-MMU-500753", "R-SPO-70635", "R-HSA-500753", "R-GGA-70635", "R-SCE-500753", "R-SPO-500753", "R-GGA-1268020", "R-HSA-70635", "R-DDI-500753", "R-SPO-1268020", "R-RNO-70635", "R-MMU-70635", "R-HSA-9956553", "R-DME-500753", "R-GGA-187630", "R-HSA-1268020", "R-MMU-1268020", "R-CEL-500753", "R-HSA-9956551", "R-SCE-1268020", "R-SCE-70635", "R-RNO-1268020"], "pathways": ["PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "R-MMU-500753:r:Pyrimidine biosynthesis", "R-SPO-70635:r:Urea cycle", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-GGA-70635:r:Urea cycle", "R-SCE-500753:r:Pyrimidine biosynthesis", "R-SPO-500753:r:Pyrimidine biosynthesis", "R-GGA-1268020:r:Mitochondrial protein import", "R-HSA-70635:r:Urea cycle", "R-DDI-500753:r:Pyrimidine biosynthesis", "R-SPO-1268020:r:Mitochondrial protein import", "R-RNO-70635:r:Urea cycle", "R-MMU-70635:r:Urea cycle", "R-HSA-9956553:r:OTC main chain variants cause OTC deficiency", "R-DME-500753:r:Pyrimidine biosynthesis", "R-GGA-187630:r:Arginine metabolism", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-1268020:r:Mitochondrial protein import", "R-CEL-500753:r:Pyrimidine biosynthesis", "R-HSA-9956551:r:OTC leader sequence variants cause OTC deficiency", "R-SCE-1268020:r:Mitochondrial protein import", "R-SCE-70635:r:Urea cycle", "R-RNO-1268020:r:Mitochondrial protein import"], "type": "Homologous_superfamily"}, "IPR036902": {"description": "Ta1353-like superfamily", "go_ids": [], "go_terms": [], "name": "Ta1353-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036903": {"description": "Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily", "go_ids": [], "go_terms": [], "name": "Nup98_auto-Pept-S59_dom_sf", "pathway_ids": ["R-CEL-159231", "R-HSA-180910", "R-RNO-9615933", "R-CEL-3301854", "R-CEL-159227", "R-MMU-2467813", "R-RNO-3301854", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-68877", "R-MMU-9615933", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-RNO-191859", "R-CEL-159230", "R-HSA-3371453", "R-CEL-4551638", "R-HSA-4570464", "R-DME-4615885", 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"R-BTA-917977", "R-HSA-983712", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-CEL-917977", "R-RNO-9639288", "R-HSA-917977", "R-DDI-917977", "R-DDI-983712", "R-MMU-983712", "R-BTA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-DDI-77387:r:Insulin receptor recycling", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-RNO-983712:r:Ion channel transport", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in 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"R-RNO-975634", "R-SCE-6782210", "R-RNO-69200", "R-BTA-6796648", "R-HSA-2173796", "R-DME-68949", "R-DME-4419969", "R-SCE-6796648", "R-DRE-8849470", "R-DDI-68616", "R-RNO-2299718", "R-RNO-2559586", "R-SPO-77075", "R-BTA-69273", "R-RNO-73772", "R-HSA-390471", "R-HSA-1362300", "R-SCE-113418", "R-BTA-174048", "R-HSA-8852276", "R-RNO-9706019", "R-MMU-73863", "R-DRE-69200", "R-HSA-6782135", "R-RNO-6782135", "R-DRE-3214858", "R-MMU-69563", "R-CEL-68949", "R-DRE-674695", "R-HSA-5687128", "R-DME-9841922", "R-HSA-176034", "R-MMU-983168", "R-MMU-4419969", "R-DDI-75953", "R-DDI-174178", "R-CEL-76042", "R-HSA-176417", "R-GGA-2980767", "R-CEL-73779", "R-HSA-69563", "R-HSA-174178", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-DME-176408", "R-HSA-8951664", "R-MMU-9754119", "R-HSA-75815", "R-MMU-6804756", "R-DDI-73776", "R-DDI-6782210", "R-MMU-75035", "R-HSA-69231", "R-MMU-2559584", "R-HSA-9617828", "R-RNO-73776", "R-BTA-6804757", "R-DRE-75955", "R-CEL-2299718", "R-MMU-1538133", "R-MMU-5689880", "R-HSA-69200", "R-HSA-69656", "R-BTA-6804756", "R-DDI-68962", "R-RNO-8964038", "R-BTA-68875", "R-BTA-2500257", "R-DME-6804116", "R-MMU-76061", "R-SPO-6796648", "R-DME-75953", "R-HSA-749476", "R-DRE-69017", "R-CEL-73776", "R-RNO-8964046", "R-RNO-5686938", "R-BTA-75955", "R-CEL-6804116", "R-HSA-9694686", "R-HSA-69478", "R-DDI-113501", "R-SPO-9018519", "R-SPO-76066", "R-MMU-2173796", "R-RNO-5696395", "R-MMU-3301854", "R-BTA-6804116", "R-RNO-2980767", "R-HSA-8934593", "R-GGA-9754119", "R-DME-1538133", "R-DME-6804756", "R-MMU-171319", "R-CEL-674695", "R-RNO-8963888", "R-RNO-6804757", "R-DME-112382", "R-HSA-6804756", "R-BTA-2559586", "R-RNO-176408", "R-HSA-6804114", "R-CEL-112382", "R-BTA-69017", "R-SPO-73779", "R-SPO-8951664", "R-DME-2559586", "R-RNO-9841922", "R-HSA-68911", "R-DDI-113418", "R-MMU-72086", "R-SPO-73776", "R-RNO-8866423", "R-DDI-68689", "R-DME-187577", "R-MMU-187577", "R-RNO-68875", "R-DDI-5696395", "R-SPO-76061", "R-RNO-174178", "R-HSA-8862803", "R-HSA-2514853", "R-DRE-8951936", "R-DME-2565942", "R-MMU-69200", "R-MMU-174178", "R-RNO-69478", "R-BTA-69563", "R-DRE-983168", "R-MMU-69202", "R-DME-73776", "R-HSA-75035", "R-RNO-2565942", "R-DDI-73772", "R-DDI-6796648", "R-HSA-6782210", "R-CEL-399956", "R-DDI-76042", "R-RNO-8856828", "R-MMU-68875", "R-CEL-69273", "R-HSA-113501", "R-SCE-73779", "R-RNO-399956", "R-BTA-399956", "R-HSA-76071", "R-MMU-6796648", "R-BTA-187577", "R-DME-69563", "R-HSA-167243", "R-RNO-6796648", "R-DDI-69231", "R-RNO-75955", "R-HSA-381340", "R-SCE-6781823", "R-SPO-69017", "R-DDI-69200", "R-DME-174184", "R-BTA-674695", "R-HSA-9634638", "R-MMU-176412", "R-MMU-3214858", "R-HSA-9725371", "R-DME-3301854", "R-HSA-167290", "R-RNO-187577", "R-MMU-174184", "R-DDI-2299718", "R-HSA-75955", "R-CEL-2565942", "R-SPO-6782210", "R-MMU-77075", "R-CEL-9018519", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-RNO-69017", "R-DME-5689880", "R-DME-69656", "R-RNO-6807505", "R-BTA-2980767", "R-HSA-167238", "R-RNO-674695", "R-BTA-9841922", "R-DME-76042", "R-RNO-2559582", "R-CEL-4419969", "R-RNO-3000497", "R-HSA-69273", "R-CEL-113501", "R-HSA-6796648", "R-HSA-9764790", "R-DME-68875"], "pathways": ["R-DME-69478:r:G2/M DNA replication checkpoint", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-BTA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-MMU-8951664:r:Neddylation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-68911:r:G2 Phase", "R-DRE-69231:r:Cyclin D associated events in G1", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-SPO-72086:r:mRNA Capping", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-DRE-69202:r:Cyclin E associated events during G1/S transition", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DRE-9706019:r:RHOBTB3 ATPase cycle", "R-BTA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SSC-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-CEL-9754119:r:Drug-mediated inhibition of CDK4/CDK6 activity", "R-DME-68911:r:G2 Phase", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-SCE-6782135:r:Dual incision in TC-NER", "R-RNO-432142:r:Platelet sensitization by LDL", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-RNO-176417:r:Phosphorylation of Emi1", "R-DME-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-CEL-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-69563:r:p53-Dependent G1 DNA Damage Response", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9661070:r:Defective translocation of RB1 mutants to the nucleus", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-2565942:r:Regulation of PLK1 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"R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9706019:r:RHOBTB3 ATPase cycle", "R-SCE-72086:r:mRNA Capping", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-GGA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-176417:r:Phosphorylation of Emi1", "R-HSA-69202:r:Cyclin E 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Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, 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Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036921": {"description": "PurM-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PurM-like_N_sf", "pathway_ids": ["R-SSC-2408557", "R-SPO-73817", "R-HSA-2408557", "R-DDI-73817", "R-MMU-2408557", "R-DME-73817", "R-DRE-2408557", "R-DME-2408557", "R-DDI-2408557", "R-CEL-2408557", "R-SCE-73817", "R-BTA-73817", "R-CEL-73817", "R-HSA-73817", "R-MMU-73817", "R-GGA-419140"], "pathways": ["R-SSC-2408557:r:Selenocysteine synthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-2408557:r:Selenocysteine synthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-2408557:r:Selenocysteine synthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DRE-2408557:r:Selenocysteine synthesis", "R-DME-2408557:r:Selenocysteine synthesis", "R-DDI-2408557:r:Selenocysteine synthesis", "R-CEL-2408557:r:Selenocysteine synthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Homologous_superfamily"}, "IPR036922": {"description": "Rieske [2Fe-2S] iron-sulphur domain superfamily", "go_ids": ["GO:0051537"], "go_terms": ["GO:0051537:2 iron, 2 sulfur cluster binding:F"], "name": "Rieske_2Fe-2S_sf", "pathway_ids": ["R-HSA-9865881", "R-DRE-9865881", "R-GGA-9865881", "R-SCE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SPO-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-MMU-611105", "R-RNO-9865881", "R-BTA-9865881", "R-SPO-611105", "R-SCE-611105", "R-SSC-9865881", "R-BTA-611105", "R-DME-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly", "R-DRE-9865881:r:Complex III assembly", "R-GGA-9865881:r:Complex III assembly", "R-SCE-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SPO-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-9865881:r:Complex III assembly", "R-BTA-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-SSC-9865881:r:Complex III assembly", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR036924": {"description": "Prion/Doppel beta-ribbon domain superfamily", "go_ids": ["GO:0051260", "GO:0016020"], "go_terms": ["GO:0051260:protein homooligomerization:P", "GO:0016020:membrane:C"], "name": "Prion/Doppel_b-ribbon_dom_sf", "pathway_ids": ["R-MMU-9609523", "R-MMU-163125", "R-HSA-9609523", "R-RNO-9609523", "R-GGA-163125", "R-HSA-419037", "R-HSA-163125", "R-GGA-9609523"], "pathways": ["R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-GGA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Homologous_superfamily"}, "IPR036925": {"description": "Translation initiation factor IF-2, domain 3 superfamily", "go_ids": [], "go_terms": [], "name": "TIF_IF2_dom3_sf", "pathway_ids": ["R-HSA-72706", "R-DDI-72706", "R-SPO-72706", "R-HSA-5368286", "R-RNO-72706", "R-SCE-72706", "R-MMU-72706"], "pathways": ["R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit"], "type": "Homologous_superfamily"}, "IPR036926": {"description": "Thymidylate synthase/dCMP hydroxymethylase superfamily", "go_ids": [], "go_terms": [], "name": "Thymidate_synth/dCMP_Mease_sf", "pathway_ids": ["PWY-7198", "PWY-7199", "PWY-7184", "PWY-7187", "PWY-7210", "PWY-3841", "R-SCE-499943", "R-DME-499943", "R-SPO-499943", "R-HSA-69205", "R-HSA-499943", "R-RNO-499943", "R-MMU-499943"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-7199:t:pyrimidine deoxyribonucleosides salvage", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-3841:t:folate transformations II (plants)", "R-SCE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SPO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Homologous_superfamily"}, "IPR036927": {"description": "Cytochrome c oxidase-like, subunit I superfamily", "go_ids": [], "go_terms": [], "name": "Cyt_c_oxase-like_su1_sf", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279", "R-MMU-9837999", "R-HSA-5419276", "R-MMU-9707564", "R-DRE-611105", "R-SSC-5628897", "R-DRE-9864848", "R-SSC-9864848", "R-HSA-5628897", "R-SSC-9707564", "R-DME-9864848", "R-RNO-5419276", "R-HSA-9707564", "R-MMU-5628897", "R-MMU-611105", "R-HSA-9837999", "R-MMU-9864848", "R-DDI-9837999", "R-CEL-9837999", "R-SSC-5419276", "R-DME-9707564", "R-DME-9837999", "R-RNO-5628897", "R-RNO-9707564", "R-RNO-9837999", "R-DME-611105", "R-DRE-9837999", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-SPO-9837999", "R-SCE-9837999", "R-MMU-5419276", "R-SSC-9837999", "R-DME-5419276", "R-CEL-5419276", "R-DRE-9707564", "R-DME-5628897", "R-CEL-9864848", "R-SSC-611105", "R-DRE-5628897"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DRE-611105:r:Respiratory electron transport", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-SSC-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9707564:r:Cytoprotection by HMOX1", "R-DME-9864848:r:Complex IV assembly", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9864848:r:Complex IV assembly", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SSC-5419276:r:Mitochondrial translation termination", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DME-611105:r:Respiratory electron transport", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-DME-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-9864848:r:Complex IV assembly", "R-SSC-611105:r:Respiratory electron transport", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Homologous_superfamily"}, "IPR036928": {"description": "Amidase signature (AS) superfamily", "go_ids": [], "go_terms": [], "name": "AS_sf", "pathway_ids": ["R-HSA-2142753", "R-DRE-2142753", "R-CEL-2142753", "R-SSC-2142753", "R-RNO-2142753", "R-MMU-2142753"], "pathways": ["R-HSA-2142753:r:Arachidonate metabolism", "R-DRE-2142753:r:Arachidonate metabolism", "R-CEL-2142753:r:Arachidonate metabolism", "R-SSC-2142753:r:Arachidonate metabolism", "R-RNO-2142753:r:Arachidonate metabolism", "R-MMU-2142753:r:Arachidonate metabolism"], "type": "Homologous_superfamily"}, "IPR036929": {"description": "Thiol:disulfide interchange protein DsbD, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DsbDN_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036930": {"description": "WGR domain superfamily", "go_ids": [], "go_terms": [], "name": "WGR_dom_sf", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-MMU-2173795", "R-HSA-3108214", "R-HSA-192814", "R-DRE-5696400", "R-RNO-5685939", "R-RNO-110362", "R-RNO-3108214", "R-DRE-5685939", "R-DRE-110362", "R-DME-5696394", "R-DRE-5696395", "R-DRE-3108214", "R-MMU-5696395", "R-RNO-2173795", "R-MMU-110362", "R-HSA-2173795", "R-MMU-5685939", "R-MMU-5696394", "R-CEL-5696394", "R-MMU-5696400", "R-RNO-5696395", "R-HSA-110362", "R-DME-5696395", "R-HSA-5685939", "R-DRE-5696394", "R-RNO-5696394", "R-DME-5696400", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-5696394", "R-RNO-5696400", "R-HSA-5696400", "R-MMU-3108214"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-192814:r:vRNA Synthesis", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Homologous_superfamily"}, "IPR036931": {"description": "Polyomavirus capsid protein VP1 superfamily", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Polyomavir_VP1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036935": {"description": "Large ribosomal subunit protein bL9, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL9_N_sf", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-DME-5389840", "R-RNO-9937383", "R-MMU-5389840", "R-HSA-5389840", "R-BTA-9937383", "R-DME-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Homologous_superfamily"}, "IPR036936": {"description": "CRIB domain superfamily", "go_ids": [], "go_terms": [], "name": "CRIB_dom_sf", "pathway_ids": ["R-HSA-5663213", "R-HSA-9013409", "R-HSA-9013405", "R-CEL-3928664", "R-BTA-3928662", "R-HSA-2871796", "R-MMU-9013408", "R-RNO-202433", "R-RNO-5687128", "R-CEL-5621575", "R-MMU-445355", "R-RNO-5218920", "R-DDI-389359", "R-CEL-9013407", "R-RNO-399954", "R-HSA-5218920", "R-MMU-9013420", "R-BTA-5663213", "R-HSA-389359", "R-DME-3928664", "R-SPO-389359", "R-DDI-445144", "R-CEL-389359", "R-HSA-203641", "R-HSA-211733", "R-DME-9013149", "R-SPO-2029482", "R-MMU-9013407", "R-RNO-445144", "R-RNO-9013407", "R-DME-5627123", "R-DME-5218920", "R-MMU-9013423", "R-DME-389359", "R-HSA-211728", "R-HSA-399954", "R-SPO-5627123", "R-BTA-203641", "R-HSA-445144", "R-MMU-5627123", "R-RNO-5621575", "R-MMU-5687128", "R-RNO-9013420", "R-BTA-202433", "R-RNO-2871796", "R-BTA-2029482", "R-CEL-5687128", "R-HSA-202433", "R-BTA-9013406", "R-HSA-5625740", "R-CEL-983168", "R-BTA-8964616", "R-MMU-8964616", "R-BTA-9013423", "R-HSA-9013423", "R-SPO-9013406", "R-SCE-3928662", "R-RNO-389359", "R-RNO-445355", "R-HSA-9013148", "R-RNO-3928662", "R-CEL-9013406", "R-SPO-9013420", "R-MMU-3928664", "R-CEL-9013423", "R-DDI-2029482", "R-BTA-8856828", "R-DDI-5687128", "R-BTA-3928664", "R-MMU-9013424", "R-BTA-5218920", "R-BTA-418885", "R-RNO-3928664", "R-RNO-9013423", "R-DDI-3928662", "R-BTA-9013404", "R-CEL-9013420", "R-HSA-428540", "R-SCE-389359", "R-DDI-9013404", "R-MMU-9013149", "R-CEL-8951664", "R-DME-9013420", "R-RNO-5627123", "R-MMU-389359", "R-BTA-9013424", "R-HSA-8856828", "R-BTA-373753", "R-DME-5621575", "R-CEL-9013424", "R-RNO-9013149", "R-DME-8964616", "R-HSA-9013424", "R-MMU-9013404", "R-MMU-4420097", "R-HSA-3928662", "R-MMU-2871796", "R-HSA-4420097", "R-BTA-389359", "R-DME-2029482", "R-RNO-9013424", "R-MMU-399954", "R-CEL-8964616", "R-HSA-164944", "R-SCE-9013420", "R-RNO-9013404", "R-RNO-9013406", "R-HSA-9013408", "R-CEL-3928662", "R-DDI-9013423", "R-RNO-9013408", "R-HSA-373753", "R-BTA-9013407", "R-MMU-5621575", "R-HSA-3928664", "R-BTA-5687128", "R-DME-3928662", "R-HSA-8950505", "R-HSA-2029482", "R-MMU-445144", "R-RNO-8964616", "R-DME-5687128", "R-HSA-9013404", "R-HSA-9013149", "R-BTA-445355", "R-DME-2871796", "R-CEL-5627123", "R-DME-445144", "R-MMU-9013406", "R-SCE-2029482", "R-SCE-445144", "R-SPO-9013424", "R-DDI-5627123", "R-SCE-5687128", "R-RNO-4420097", "R-HSA-9013407", "R-SPO-5687128", "R-SCE-5627123", "R-HSA-418885", "R-DME-9013424", "R-DDI-9013149", "R-CEL-9013149", "R-RNO-2029482", "R-BTA-5627123", "R-HSA-211736", "R-SCE-9013406", "R-BTA-399954", "R-HSA-5621575", "R-BTA-2871796", "R-DME-9013406", "R-SCE-9013424", "R-DME-9013407", "R-BTA-9013420", "R-MMU-202433", "R-HSA-9013420", "R-HSA-445355", "R-MMU-5218920", "R-CEL-445144", "R-HSA-8964616", "R-MMU-2029482", "R-CEL-2029482", "R-DDI-5621575", "R-DRE-9013148", "R-HSA-5627123", "R-CEL-4420097", "R-HSA-5687128", "R-MMU-3928662", "R-HSA-9013406", "R-HSA-9664422", "R-DME-9013423", "R-CEL-5218920", "R-HSA-5627117"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-CEL-3928664:r:Ephrin signaling", "R-BTA-3928662:r:EPHB-mediated forward signaling", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-202433:r:Generation of second messenger molecules", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-DDI-389359:r:CD28 dependent Vav1 pathway", "R-CEL-9013407:r:RHOH GTPase cycle", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-9013420:r:RHOU GTPase cycle", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-DME-3928664:r:Ephrin signaling", "R-SPO-389359:r:CD28 dependent Vav1 pathway", "R-DDI-445144:r:Signal transduction by L1", "R-CEL-389359:r:CD28 dependent Vav1 pathway", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DME-9013149:r:RAC1 GTPase cycle", "R-SPO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-9013407:r:RHOH GTPase cycle", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-DME-389359:r:CD28 dependent Vav1 pathway", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-BTA-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-BTA-202433:r:Generation of second messenger molecules", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-SCE-3928662:r:EPHB-mediated forward signaling", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-RNO-445355:r:Smooth Muscle Contraction", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-3928664:r:Ephrin signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-BTA-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-418885:r:DCC mediated attractive signaling", "R-RNO-3928664:r:Ephrin signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-CEL-9013420:r:RHOU GTPase cycle", "R-HSA-428540:r:Activation of RAC1", "R-SCE-389359:r:CD28 dependent Vav1 pathway", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-8951664:r:Neddylation", "R-DME-9013420:r:RHOU GTPase cycle", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-BTA-9013424:r:RHOV GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-373753:r:Nephrin family interactions", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DME-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9013424:r:RHOV GTPase cycle", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-164944:r:Nef and signal transduction", "R-SCE-9013420:r:RHOU GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-373753:r:Nephrin family interactions", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-3928664:r:Ephrin signaling", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-445144:r:Signal transduction by L1", "R-RNO-8964616:r:G beta:gamma signalling through CDC42", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-445355:r:Smooth Muscle Contraction", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-CEL-5627123:r:RHO GTPases activate PAKs", "R-DME-445144:r:Signal transduction by L1", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SCE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SCE-445144:r:Signal transduction by L1", "R-SPO-9013424:r:RHOV GTPase cycle", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-HSA-418885:r:DCC mediated attractive signaling", "R-DME-9013424:r:RHOV GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-HSA-211736:r:Stimulation of the cell death response by PAK-2p34", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-DME-9013406:r:RHOQ GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-DME-9013407:r:RHOH GTPase cycle", "R-BTA-9013420:r:RHOU GTPase cycle", "R-MMU-202433:r:Generation of second messenger molecules", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-445355:r:Smooth Muscle Contraction", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-8964616:r:G beta:gamma signalling through CDC42", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DME-9013423:r:RAC3 GTPase cycle", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Homologous_superfamily"}, "IPR036937": {"description": "Fimbrial-type adhesion domain superfamily", "go_ids": ["GO:0007155", "GO:0009289"], "go_terms": ["GO:0007155:cell adhesion:P", "GO:0009289:pilus:C"], "name": "Adhesion_dom_fimbrial_sf", "pathway_ids": ["R-HSA-9638630"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells"], "type": "Homologous_superfamily"}, "IPR036938": {"description": "Phosphatidic acid phosphatase type 2/haloperoxidase superfamily", "go_ids": [], "go_terms": [], "name": "PAP2/HPO_sf", "pathway_ids": ["R-DDI-419408", "R-SCE-9845614", "R-SPO-2029485", "R-BTA-9845614", "R-DRE-419408", "R-HSA-419408", "R-DME-419408", "R-RNO-9845614", "R-SPO-419408", "R-SCE-2029485", "R-DDI-446199", "R-HSA-2029485", "R-MMU-70263", "R-XTR-419408", "R-MMU-419408", "R-DRE-9969896", "R-HSA-9615017", "R-HSA-70263", "R-SPO-9845614", "R-MMU-2029485", "R-BTA-9969896", "R-DDI-2029485", "R-SCE-419408", "R-HSA-3274531", "R-HSA-9969896", "R-RNO-419408", "R-DRE-70263", "R-DME-9845614", "R-CEL-9845614", "R-MMU-9969896", "R-CEL-419408", "R-MMU-9845614", "R-HSA-446199", "R-DDI-9845614", "R-SSC-9845614", "R-SPO-446199", "R-BTA-70263", "R-HSA-9845614", "R-MMU-446199", "R-HSA-3282872", "R-RNO-9969896", "R-RNO-70263"], "pathways": ["R-DDI-419408:r:Lysosphingolipid and LPA receptors", "R-SCE-9845614:r:Sphingolipid catabolism", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-9845614:r:Sphingolipid catabolism", "R-DRE-419408:r:Lysosphingolipid and LPA receptors", "R-HSA-419408:r:Lysosphingolipid and LPA receptors", "R-DME-419408:r:Lysosphingolipid and LPA receptors", "R-RNO-9845614:r:Sphingolipid catabolism", "R-SPO-419408:r:Lysosphingolipid and LPA receptors", "R-SCE-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-70263:r:Gluconeogenesis", "R-XTR-419408:r:Lysosphingolipid and LPA receptors", "R-MMU-419408:r:Lysosphingolipid and LPA receptors", "R-DRE-9969896:r:Lanosterol biosynthesis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-70263:r:Gluconeogenesis", "R-SPO-9845614:r:Sphingolipid catabolism", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-SCE-419408:r:Lysosphingolipid and LPA receptors", "R-HSA-3274531:r:Glycogen storage disease type Ia (G6PC)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-RNO-419408:r:Lysosphingolipid and LPA receptors", "R-DRE-70263:r:Gluconeogenesis", "R-DME-9845614:r:Sphingolipid catabolism", "R-CEL-9845614:r:Sphingolipid catabolism", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-CEL-419408:r:Lysosphingolipid and LPA receptors", "R-MMU-9845614:r:Sphingolipid catabolism", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-DDI-9845614:r:Sphingolipid catabolism", "R-SSC-9845614:r:Sphingolipid catabolism", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-70263:r:Gluconeogenesis", "R-HSA-9845614:r:Sphingolipid catabolism", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-3282872:r:Severe congenital neutropenia type 4 (G6PC3)", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Homologous_superfamily"}, "IPR036939": {"description": "Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily", "go_ids": ["GO:0005507", "GO:0004497", "GO:0016715"], "go_terms": ["GO:0005507:copper 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cascade:FGFR2", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-201556:r:Signaling by ALK", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-DME-9664873:r:Pexophagy", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-186763:r:Downstream signal transduction", "R-RNO-165159:r:MTOR signalling", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-1632852:r:Macroautophagy", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-5693548:r:Sensing of DNA Double Strand Breaks", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-165159:r:MTOR signalling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", 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mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-XTR-156711:r:Polo-like kinase mediated events", "R-BTA-68881:r:Mitotic Metaphase/Anaphase Transition", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-156711:r:Polo-like kinase mediated events", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DDI-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-XTR-68877:r:Mitotic Prometaphase", "R-SCE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-176412:r:Phosphorylation of the APC/C", "R-XTR-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-CEL-156711:r:Polo-like kinase mediated events", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-176417:r:Phosphorylation of Emi1", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-176417:r:Phosphorylation of Emi1"], "type": "Homologous_superfamily"}, "IPR036948": {"description": "Large ribosomal subunit protein eL21 superfamily", "go_ids": ["GO:0006412", "GO:0003735", "GO:0005840"], "go_terms": ["GO:0006412:translation:P", "GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C"], "name": "Ribosomal_eL21_sf", "pathway_ids": ["R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-SPO-9954709", "R-HSA-1799339", "R-MMU-6791226", "R-SPO-975956", "R-HSA-2408557", "R-MMU-9954714", "R-SPO-72706", "R-SSC-9954714", "R-CEL-1799339", "R-SCE-975956", "R-HSA-72706", "R-CEL-156827", "R-SSC-1799339", "R-SSC-975957", "R-HSA-6791226", "R-SSC-72689", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-MMU-72689", "R-SCE-72706", "R-HSA-156827", "R-MMU-9954709", "R-HSA-192823", "R-SSC-9954716", "R-SSC-156827", "R-SCE-975957", "R-HSA-9954709", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SSC-9954709", "R-SCE-9954714", "R-MMU-156827", "R-HSA-975957", "R-SSC-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DDI-156827", "R-DDI-9954716", "R-HSA-9633012"], "pathways": ["R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036950": {"description": "Transglycosylase domain", "go_ids": [], "go_terms": [], "name": "Transglycosylase", "pathway_ids": ["R-HSA-9638771"], "pathways": ["R-HSA-9638771:r:Action of antimicrobials"], "type": "Homologous_superfamily"}, "IPR036951": {"description": "Aromatic amino acid hydroxylase superfamily", "go_ids": ["GO:0009072", "GO:0004497", "GO:0005506"], "go_terms": ["GO:0009072:aromatic amino acid metabolic process:P", "GO:0004497:monooxygenase activity:F", "GO:0005506:iron ion binding:F"], "name": "ArAA_hydroxylase_sf", "pathway_ids": ["R-HSA-2160456", "R-HSA-8964208", "R-MMU-209905", "R-DDI-209931", "R-DME-209905", "R-HSA-209905", "R-DME-8964208", "R-BTA-8964208", "R-MMU-8964208", "R-CEL-209905", "R-RNO-8964208", "R-RNO-209905", "R-HSA-209931", "R-DDI-8964208", "R-CEL-8964208", "R-HSA-9031628", "R-DDI-209905", "R-RNO-209931", "R-MMU-209931"], "pathways": ["R-HSA-2160456:r:Phenylketonuria", "R-HSA-8964208:r:Phenylalanine metabolism", "R-MMU-209905:r:Catecholamine biosynthesis", "R-DDI-209931:r:Serotonin and melatonin biosynthesis", "R-DME-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-DME-8964208:r:Phenylalanine metabolism", "R-BTA-8964208:r:Phenylalanine metabolism", "R-MMU-8964208:r:Phenylalanine metabolism", "R-CEL-209905:r:Catecholamine biosynthesis", "R-RNO-8964208:r:Phenylalanine metabolism", "R-RNO-209905:r:Catecholamine biosynthesis", "R-HSA-209931:r:Serotonin and melatonin biosynthesis", "R-DDI-8964208:r:Phenylalanine metabolism", "R-CEL-8964208:r:Phenylalanine metabolism", "R-HSA-9031628:r:NGF-stimulated transcription", "R-DDI-209905:r:Catecholamine biosynthesis", "R-RNO-209931:r:Serotonin and melatonin biosynthesis", "R-MMU-209931:r:Serotonin and melatonin biosynthesis"], "type": "Homologous_superfamily"}, "IPR036952": {"description": "Parvovirus coat protein VP1/VP2", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "VP1/VP2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036953": {"description": "Transcription elongation factor GreA/GreB, C-terminal domain superfamily", "go_ids": ["GO:0032784", "GO:0003677"], "go_terms": ["GO:0032784:regulation of DNA-templated transcription elongation:P", "GO:0003677:DNA binding:F"], "name": "GreA/GreB_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036954": {"description": "Collagen IV, non-collagenous domain superfamily", "go_ids": ["GO:0005201", "GO:0005581"], "go_terms": ["GO:0005201:extracellular matrix structural constituent:F", "GO:0005581:collagen trimer:C"], "name": "Collagen_IV_NC_sf", "pathway_ids": ["R-HSA-186797", "R-CEL-1592389", "R-BTA-2243919", "R-CEL-2022090", "R-HSA-2243919", "R-BTA-216083", "R-DME-419037", "R-CEL-1650814", "R-HSA-3000480", "R-HSA-3000178", "R-HSA-3000157", "R-HSA-9010553", "R-BTA-1442490", "R-CEL-1566977", "R-MMU-419037", "R-BTA-2022090", "R-MMU-2243919", "R-HSA-1650814", "R-HSA-9638630", "R-MMU-3000171", "R-CEL-2243919", "R-BTA-3000171", "R-HSA-8948216", "R-BTA-186797", "R-CEL-204005", "R-CEL-3000157", "R-HSA-1442490", "R-BTA-1650814", "R-CEL-216083", "R-HSA-2214320", "R-MMU-3000157", "R-CEL-5694530", "R-HSA-216083", "R-MMU-1566977", "R-DME-1650814", "R-CEL-2214320", "R-BTA-1566977", "R-HSA-1566977", "R-HSA-3000171", "R-CEL-186797", "R-DME-446107", "R-DME-8948216", "R-CEL-8948216", "R-HSA-419037", "R-MMU-2022090", "R-DME-216083", "R-HSA-2022090", "R-MMU-1650814", "R-MMU-216083", "R-CEL-1442490", "R-MMU-186797", "R-MMU-1442490", "R-CEL-3000171", "R-CEL-419037", "R-DME-186797"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-CEL-1592389:r:Activation of Matrix Metalloproteinases", "R-BTA-2243919:r:Crosslinking of collagen fibrils", "R-CEL-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-BTA-216083:r:Integrin cell surface interactions", "R-DME-419037:r:NCAM1 interactions", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3000157:r:Laminin interactions", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-1442490:r:Collagen degradation", "R-CEL-1566977:r:Fibronectin matrix formation", "R-MMU-419037:r:NCAM1 interactions", "R-BTA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-BTA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-8948216:r:Collagen chain trimerization", "R-BTA-186797:r:Signaling by PDGF", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-CEL-3000157:r:Laminin interactions", "R-HSA-1442490:r:Collagen degradation", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-2214320:r:Anchoring fibril formation", "R-MMU-3000157:r:Laminin interactions", "R-CEL-5694530:r:Cargo concentration in the ER", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-CEL-2214320:r:Anchoring fibril formation", "R-BTA-1566977:r:Fibronectin matrix formation", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-186797:r:Signaling by PDGF", "R-DME-446107:r:Type I hemidesmosome assembly", "R-DME-8948216:r:Collagen chain trimerization", "R-CEL-8948216:r:Collagen chain trimerization", "R-HSA-419037:r:NCAM1 interactions", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-216083:r:Integrin cell surface interactions", "R-CEL-1442490:r:Collagen degradation", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-1442490:r:Collagen degradation", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-419037:r:NCAM1 interactions", "R-DME-186797:r:Signaling by PDGF"], "type": "Homologous_superfamily"}, "IPR036955": {"description": "AP2/ERF domain superfamily", "go_ids": ["GO:0006355", "GO:0003700"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "AP2/ERF_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036956": {"description": "Impact, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Impact_N_sf", "pathway_ids": ["R-HSA-9633012"], "pathways": ["R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036957": {"description": "Zinc finger, PARP-type superfamily", "go_ids": ["GO:0008270", "GO:0003677"], "go_terms": ["GO:0008270:zinc ion binding:F", "GO:0003677:DNA binding:F"], "name": "Znf_PARP_sf", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-MMU-2173795", "R-MMU-5649702", "R-HSA-3108214", "R-HSA-192814", "R-HSA-5696397", "R-DRE-5696400", "R-RNO-5685939", "R-RNO-110362", "R-RNO-3108214", "R-MMU-110381", "R-DRE-5685939", "R-HSA-5649702", "R-DRE-110362", "R-DME-5696394", "R-DRE-5696395", "R-DRE-3108214", "R-MMU-5696395", "R-RNO-2173795", "R-MMU-110362", "R-HSA-2173795", "R-MMU-5685939", "R-HSA-6782210", "R-MMU-5696394", "R-CEL-5696394", "R-MMU-5696400", "R-RNO-5696395", "R-HSA-110362", "R-DME-5696395", "R-HSA-5685939", "R-DRE-5696394", "R-RNO-5696394", "R-HSA-110381", "R-DME-5696400", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-5696394", "R-RNO-5696400", "R-HSA-5696400", "R-MMU-6782210", "R-MMU-3108214", "R-HSA-9913635"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DME-5696400:r:Dual Incision in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR036959": {"description": "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily", "go_ids": ["GO:0006511", "GO:0004843"], "go_terms": ["GO:0006511:ubiquitin-dependent protein catabolic process:P", "GO:0004843:cysteine-type deubiquitinase activity:F"], "name": "Peptidase_C12_UCH_sf", "pathway_ids": ["R-BTA-8951664", "R-SSC-5689603", "R-SCE-5689603", "R-HSA-8951664", "R-DME-8951664", "R-RNO-5693565", "R-PFA-8866652", "R-RNO-8866652", "R-HSA-5693565", "R-MMU-8866652", "R-DDI-5693565", "R-DME-8866652", "R-DDI-8951664", "R-MMU-5693565", "R-MMU-8951664", "R-RNO-5689603", "R-HSA-8866652", "R-CEL-5689603", "R-DDI-5689603", "R-DME-5689603", "R-MMU-5689603", "R-HSA-2173788", "R-PFA-5689603", "R-SPO-5689603", "R-DRE-5689603", "R-BTA-5689603", "R-SCE-8951664", "R-BTA-8866652", "R-RNO-8951664", "R-SPO-8951664", "R-HSA-5689603", "R-PFA-8951664", "R-DDI-8866652", "R-XTR-5689603"], "pathways": ["R-BTA-8951664:r:Neddylation", "R-SSC-5689603:r:UCH proteinases", "R-SCE-5689603:r:UCH proteinases", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-PFA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-8951664:r:Neddylation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-8951664:r:Neddylation", "R-RNO-5689603:r:UCH proteinases", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-CEL-5689603:r:UCH proteinases", "R-DDI-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-PFA-5689603:r:UCH proteinases", "R-SPO-5689603:r:UCH proteinases", "R-DRE-5689603:r:UCH proteinases", "R-BTA-5689603:r:UCH proteinases", "R-SCE-8951664:r:Neddylation", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-5689603:r:UCH proteinases", "R-PFA-8951664:r:Neddylation", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-XTR-5689603:r:UCH proteinases"], "type": "Homologous_superfamily"}, "IPR036960": {"description": "T-box superfamily", "go_ids": ["GO:0006355", "GO:0003700", "GO:0005634"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C"], "name": "T-box_sf", "pathway_ids": ["R-MMU-9856649", "R-MMU-8953750", "R-HSA-2032785", "R-HSA-9942503", "R-RNO-9856649", "R-CEL-2032785", "R-HSA-9758919", "R-DME-9856649", "R-HSA-9824272", "R-HSA-8953750", "R-HSA-5578768", "R-HSA-9754189", "R-HSA-9827857", "R-RNO-2032785", "R-HSA-9832991", "R-HSA-9823730", "R-HSA-9733709", "R-HSA-9793380", "R-HSA-9796292", "R-HSA-9856649", "R-CEL-8953750", "R-MMU-2032785", "R-CEL-9856649", "R-DRE-2032785", "R-HSA-9825892"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9758919:r:Epithelial-Mesenchymal Transition (EMT) during gastrulation", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9824272:r:Somitogenesis", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-5578768:r:Physiological factors", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-HSA-9827857:r:Specification of primordial germ cells", "R-RNO-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9832991:r:Formation of the posterior neural plate", "R-HSA-9823730:r:Formation of definitive endoderm", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DRE-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "type": "Homologous_superfamily"}, "IPR036961": {"description": "Kinesin motor domain superfamily", "go_ids": [], "go_terms": [], "name": "Kinesin_motor_dom_sf", "pathway_ids": ["R-RNO-9013026", "R-RNO-5625970", "R-DME-190873", "R-HSA-9013418", "R-BTA-983189", "R-DME-216217", "R-HSA-264876", "R-MMU-445355", "R-MMU-68877", "R-DME-445355", "R-HSA-6811434", "R-XTR-6811434", "R-MMU-9013420", "R-HSA-9662360", "R-HSA-432040", "R-DME-2453902", "R-MMU-5610787", "R-SCE-9013425", "R-BTA-5250924", "R-MMU-5620912", "R-MMU-6811434", "R-MMU-9013419", "R-MMU-9035034", "R-HSA-5620924", "R-RNO-9824585", "R-MMU-5625900", "R-HSA-437239", "R-HSA-141444", "R-RNO-9013148", "R-HSA-373752", "R-DME-68884", "R-CEL-5620924", "R-RNO-5663220", "R-MMU-432040", "R-SPO-5627123", "R-HSA-1445148", "R-SPO-190873", "R-HSA-9013026", "R-DRE-9013026", "R-DRE-8980692", "R-MMU-5627123", "R-RNO-5620924", "R-MMU-9013418", "R-HSA-9609736", "R-DDI-9013418", "R-MMU-5663220", "R-RNO-141444", "R-HSA-1839117", "R-BTA-68884", "R-HSA-416572", "R-HSA-2467813", "R-HSA-5625900", "R-HSA-9662834", "R-RNO-9035034", "R-MMU-8980692", "R-HSA-190873", "R-RNO-8980692", "R-MMU-983189", "R-HSA-5625740", "R-HSA-9013106", "R-DDI-9013422", "R-DME-209338", "R-SPO-68884", "R-MMU-190873", "R-HSA-68877", "R-MMU-2132295", "R-HSA-9013148", "R-SPO-9013420", "R-RNO-8985586", "R-DME-216119", "R-SCE-983189", "R-BTA-2132295", "R-DME-209360", "R-RNO-2132295", "R-MMU-437239", "R-RNO-68877", "R-DDI-5610787", "R-HSA-9696270", "R-HSA-399719", "R-DRE-9013424", "R-MMU-68884", "R-MMU-9013424", "R-DDI-983189", "R-DME-350480", "R-DME-9013422", "R-MMU-5625970", "R-SPO-983189", "R-DDI-68884", "R-HSA-5663220", "R-MMU-9696270", "R-RNO-432040", "R-RNO-9648025", "R-MMU-9696273", "R-MMU-9013149", "R-HSA-9725370", "R-SCE-190873", "R-HSA-5625970", "R-DME-9013420", "R-MMU-5632684", "R-HSA-9013422", "R-MMU-9013106", "R-RNO-983189", "R-MMU-2467813", "R-DRE-5632684", "R-CEL-2453902", "R-RNO-9013149", "R-HSA-9013424", "R-HSA-9013425", "R-MMU-9013422", "R-RNO-9013424", "R-SPO-9696273", "R-SCE-9013420", "R-HSA-5655302", "R-MMU-5620924", "R-GGA-6811434", "R-MMU-5250924", "R-MMU-141444", "R-MMU-5635838", "R-MMU-390522", "R-MMU-2453902", "R-HSA-2029482", "R-HSA-9648025", "R-GGA-9824585", "R-CEL-983189", "R-HSA-9013149", "R-HSA-8980692", "R-DRE-983189", "R-HSA-68884", "R-HSA-5635838", "R-DDI-5627123", "R-RNO-2467813", "R-GGA-983189", "R-HSA-2132295", "R-RNO-2500257", "R-SCE-5627123", "R-MMU-9013148", "R-RNO-2029482", "R-BTA-5627123", "R-DME-209214", "R-DME-983189", "R-HSA-5610787", "R-HSA-9035034", "R-DME-209159", "R-MMU-9824585", "R-MMU-9013425", "R-RNO-9013106", "R-MMU-9648025", "R-HSA-5620912", "R-DME-209190", "R-MMU-2500257", "R-HSA-9013420", "R-RNO-6811434", "R-HSA-2500257", "R-RNO-390522", "R-HSA-445355", "R-HSA-390471", "R-SPO-9013419", "R-SPO-9013425", "R-HSA-9662361", "R-HSA-9927432", "R-RNO-5250924", "R-MMU-8985586", "R-HSA-5632684", "R-MMU-2029482", "R-DME-9013418", "R-HSA-9824585", "R-XTR-983189", "R-HSA-9703465", "R-HSA-8985586", "R-HSA-3928663", "R-HSA-5627123", "R-HSA-983189", "R-MMU-9013026", "R-HSA-390522", "R-SCE-9013419", "R-HSA-5250924", "R-HSA-9013419", "R-HSA-9664422", "R-MMU-399719", "R-HSA-9696273", "R-HSA-5627117", "R-HSA-2453902"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-RNO-5625970:r:RHO GTPases activate KTN1", "R-DME-190873:r:Gap junction degradation", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-BTA-983189:r:Kinesins", "R-DME-216217:r:Activation of SMO", "R-HSA-264876:r:Insulin processing", "R-MMU-445355:r:Smooth Muscle Contraction", "R-MMU-68877:r:Mitotic Prometaphase", "R-DME-445355:r:Smooth Muscle Contraction", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-5610787:r:Hedgehog 'off' state", "R-SCE-9013425:r:RHOT1 GTPase cycle", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-9013419:r:RHOT2 GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-DME-68884:r:Mitotic Telophase/Cytokinesis", "R-CEL-5620924:r:Intraflagellar transport", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-SPO-190873:r:Gap junction degradation", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-9013026:r:RHOB GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-5620924:r:Intraflagellar transport", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-BTA-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-190873:r:Gap junction degradation", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-983189:r:Kinesins", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-SPO-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-190873:r:Gap junction degradation", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-DME-216119:r:Activation of CI", "R-SCE-983189:r:Kinesins", "R-BTA-2132295:r:MHC class II antigen presentation", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-68877:r:Mitotic Prometaphase", "R-DDI-5610787:r:Hedgehog 'off' state", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-DRE-9013424:r:RHOV GTPase cycle", "R-MMU-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DDI-983189:r:Kinesins", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5625970:r:RHO GTPases activate KTN1", "R-SPO-983189:r:Kinesins", "R-DDI-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9696270:r:RND2 GTPase cycle", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-SCE-190873:r:Gap junction degradation", "R-HSA-5625970:r:RHO GTPases activate KTN1", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-983189:r:Kinesins", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DRE-5632684:r:Hedgehog 'on' state", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-SCE-9013420:r:RHOU GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-5620924:r:Intraflagellar transport", "R-GGA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5635838:r:Activation of SMO", "R-MMU-390522:r:Striated Muscle Contraction", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-CEL-983189:r:Kinesins", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DRE-983189:r:Kinesins", "R-HSA-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-5635838:r:Activation of SMO", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-GGA-983189:r:Kinesins", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-DME-209214:r:Phosphorylation of SMO", "R-DME-983189:r:Kinesins", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-209159:r:Assembly of the CI containing complexes", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-209190:r:Phosphorylation of CI", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SPO-9013419:r:RHOT2 GTPase cycle", "R-SPO-9013425:r:RHOT1 GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-XTR-983189:r:Kinesins", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-HSA-983189:r:Kinesins", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-390522:r:Striated Muscle Contraction", "R-SCE-9013419:r:RHOT2 GTPase cycle", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Homologous_superfamily"}, "IPR036962": {"description": "Glycoside hydrolase, family 3, N-terminal domain superfamily", "go_ids": ["GO:0005975", "GO:0004553"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "Glyco_hydro_3_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036963": {"description": "Tat domain superfamily", "go_ids": [], "go_terms": [], "name": "Tat_dom_sf", "pathway_ids": ["R-HSA-167246", "R-HSA-167200", "R-HSA-167238", "R-HSA-9833482", "R-HSA-167243", "R-HSA-176034"], "pathways": ["R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-HSA-176034:r:Interactions of Tat with host cellular proteins"], "type": "Homologous_superfamily"}, "IPR036964": {"description": "Ras guanine-nucleotide exchange factor, catalytic domain superfamily", "go_ids": ["GO:0007264", "GO:0005085"], "go_terms": ["GO:0007264:small GTPase-mediated signal transduction:P", "GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "RASGEF_cat_dom_sf", "pathway_ids": ["R-HSA-9607240", "R-MMU-180336", "R-BTA-5673001", "R-HSA-2871796", "R-HSA-912631", "R-MMU-210993", "R-HSA-9027284", "R-HSA-442982", "R-CEL-9607240", "R-DDI-5213460", "R-MMU-5654706", "R-SCE-8980692", "R-HSA-8853659", "R-DME-74751", "R-MMU-8851805", "R-DDI-5673000", "R-MMU-5673001", "R-MMU-186763", "R-RNO-193648", "R-DME-1433559", "R-MMU-167044", "R-CEL-1855204", "R-DME-9607240", "R-DME-9013149", "R-HSA-983695", "R-HSA-2424491", "R-MMU-392517", "R-DDI-5673001", "R-HSA-416482", "R-RNO-9013148", "R-HSA-8983432", "R-SCE-193648", "R-CEL-74751", "R-HSA-5637810", "R-HSA-5654699", "R-MMU-912526", "R-MMU-171007", "R-HSA-1433559", "R-HSA-5654700", "R-DDI-5674135", "R-CEL-1433557", "R-CEL-8851805", "R-DME-193648", "R-MMU-179812", "R-DME-416482", "R-MMU-193648", "R-HSA-1855204", "R-DRE-8980692", "R-MMU-2730905", "R-MMU-5654712", "R-HSA-179812", "R-MMU-354192", "R-HSA-392517", "R-HSA-9680350", "R-HSA-5655253", "R-DME-180336", "R-DME-5673001", "R-MMU-8980692", "R-MMU-5654699", "R-RNO-8980692", "R-SCE-6798695", "R-HSA-9665348", "R-HSA-2428933", "R-SCE-381676", "R-CEL-2179392", "R-DME-1433557", "R-HSA-9013423", "R-XTR-5673001", "R-RNO-416482", "R-RNO-354192", "R-CEL-5654712", "R-MMU-1250347", "R-CEL-354192", "R-HSA-9013148", "R-MMU-5654704", "R-HSA-1250196", "R-HSA-2730905", "R-MMU-112412", "R-HSA-5654719", "R-DME-5654699", "R-CEL-193648", "R-HSA-1963640", "R-HSA-5655291", "R-HSA-5655332", "R-DME-5654719", "R-DME-2179392", "R-DME-112412", "R-DDI-392517", "R-DME-167044", "R-HSA-5654712", "R-HSA-2871809", "R-HSA-9034864", "R-MMU-9028731", "R-MMU-354194", "R-MMU-8983432", "R-HSA-74749", "R-HSA-9842663", "R-DDI-5675221", "R-DME-2730905", 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"R-HSA-9665686", "R-MMU-1433557", "R-HSA-210993", "R-MMU-8853659", "R-MMU-5654700", "R-DME-5654688", "R-SCE-354192", "R-HSA-5673001", "R-SCE-9013148", "R-HSA-9013149", "R-DME-2871796", "R-HSA-8980692", "R-SCE-9035034", "R-DME-8853659", "R-HSA-9703648", "R-HSA-381676", "R-CEL-1963640", "R-DME-1963640", "R-BTA-354192", "R-CEL-186763", "R-MMU-5654688", "R-DRE-416482", "R-HSA-5654704", "R-SCE-392517", "R-MMU-375165", "R-CEL-375165", "R-MMU-1169092", "R-MMU-2179392", "R-HSA-167044", "R-SCE-9013423", "R-DME-5654700", "R-HSA-74751", "R-MMU-422356", "R-DME-5654693", "R-MMU-9013148", "R-HSA-375165", "R-HSA-1250347", "R-DDI-9013149", "R-DME-2428933", "R-MMU-9842663", "R-CEL-9013149", "R-HSA-2871837", "R-DDI-381676", "R-HSA-9673770", "R-HSA-114508", "R-CEL-5654706", "R-HSA-1169092", "R-DME-2871809", "R-HSA-1236382", "R-DRE-9013149", "R-CEL-5654699", "R-DME-1250347", "R-SCE-9013424", "R-MMU-1855204", "R-HSA-8851805", "R-MMU-5654719", "R-HSA-9028731", "R-HSA-171007", "R-HSA-354192", "R-HSA-193648", "R-RNO-171007", "R-DDI-171007", "R-DDI-3295583", "R-CEL-392517", "R-HSA-5654706", "R-HSA-354194", "R-HSA-9679191", "R-MMU-983695", "R-DDI-1169092", "R-HSA-1433557", "R-RNO-381676", "R-CEL-381676", "R-CEL-180336", "R-HSA-186763", "R-RNO-1169092", "R-HSA-9703465", "R-DRE-9013148", "R-MMU-2871809", "R-HSA-112412", "R-MMU-416482", "R-MMU-2424491", "R-RNO-1855204", "R-DME-179812", "R-DME-9013423", "R-CEL-5654704"], "pathways": ["R-HSA-9607240:r:FLT3 Signaling", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-CEL-9607240:r:FLT3 Signaling", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-SCE-8980692:r:RHOA GTPase cycle", "R-HSA-8853659:r:RET signaling", "R-DME-74751:r:Insulin receptor signalling cascade", "R-MMU-8851805:r:MET activates RAS signaling", "R-DDI-5673000:r:RAF activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-RNO-193648:r:NRAGE signals death through JNK", "R-DME-1433559:r:Regulation of KIT signaling", "R-MMU-167044:r:Signalling to RAS", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DME-9607240:r:FLT3 Signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2424491:r:DAP12 signaling", "R-MMU-392517:r:Rap1 signalling", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SCE-193648:r:NRAGE signals death through JNK", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-MMU-171007:r:p38MAPK events", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-8851805:r:MET activates RAS signaling", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DME-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-MMU-354192:r:Integrin signaling", "R-HSA-392517:r:Rap1 signalling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-SCE-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-RNO-354192:r:Integrin signaling", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-354192:r:Integrin signaling", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-112412:r:SOS-mediated signalling", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-5654699:r:SHC-mediated cascade:FGFR2", "R-CEL-193648:r:NRAGE signals death through JNK", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-DME-112412:r:SOS-mediated signalling", "R-DDI-392517:r:Rap1 signalling", "R-DME-167044:r:Signalling to RAS", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-74749:r:Signal attenuation", "R-HSA-9842663:r:Signaling by LTK", 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"R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036968": {"description": "Enolpyruvate transferase domain 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"R-SPO-75105", "R-DME-9837999", "R-RNO-9837999", "R-SSC-9854311", "R-MMU-75105", "R-DRE-71403", "R-DRE-9837999", "R-BTA-75105", "R-SSC-71403", "R-SPO-9837999", "R-SCE-71403", "R-SCE-9837999", "R-HSA-75105", "R-SSC-9837999", "R-MMU-6798695", "R-DME-71403", "R-XTR-71403", "R-CEL-75105"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9837999:r:Mitochondrial protein degradation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-DME-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Homologous_superfamily"}, "IPR036971": {"description": "3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily", "go_ids": ["GO:0007165", "GO:0004114"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0004114:3',5'-cyclic-nucleotide phosphodiesterase activity:F"], "name": "PDEase_catalytic_dom_sf", "pathway_ids": ["R-RNO-9860927", "R-PFA-418457", "R-HSA-418457", "R-MMU-9013422", "R-DME-418457", "R-RNO-445355", "R-MMU-180024", "R-MMU-2514859", "R-RNO-418457", "R-HSA-4086398", "R-CFA-2485179", "R-CFA-4086398", "R-DDI-418555", "R-HSA-180024", "R-DDI-165160", "R-DDI-2485179", "R-DME-111957", "R-HSA-445355", "R-HSA-2514859", "R-CEL-9860927", "R-CEL-418457", "R-RNO-2485179", "R-PFA-445355", "R-HSA-418555", "R-CFA-445355", "R-BTA-111957", "R-DME-180024", "R-DME-9013422", "R-RNO-180024", "R-BTA-418457", "R-PFA-418555", "R-BTA-9013422", "R-CFA-418457", "R-RNO-4086398", "R-BTA-445355", "R-CEL-180024", "R-CFA-9013422", "R-BTA-418555", "R-DDI-445355", "R-RNO-111957", "R-DDI-4086398", "R-MMU-2485179", "R-HSA-9860927", "R-HSA-111957", "R-SCE-165160", "R-SCE-418555", "R-HSA-165160", "R-PFA-165160", "R-MMU-418555", "R-MMU-9860927", "R-DDI-111957", "R-CEL-165160", "R-DDI-418457", "R-RNO-418555", "R-CEL-111957", "R-HSA-9013422", "R-DME-418555", "R-RNO-9013422", "R-MMU-4086398", "R-HSA-2485179", "R-RNO-2514859", "R-MMU-165160", "R-RNO-165160", "R-MMU-445355", "R-DME-445355", "R-DME-9860927", "R-MMU-418457", "R-MMU-111957", "R-DDI-9013422", "R-CEL-418555"], "pathways": ["R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-PFA-418457:r:cGMP effects", "R-HSA-418457:r:cGMP effects", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DME-418457:r:cGMP effects", "R-RNO-445355:r:Smooth Muscle Contraction", "R-MMU-180024:r:DARPP-32 events", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-418457:r:cGMP effects", "R-HSA-4086398:r:Ca2+ pathway", "R-CFA-2485179:r:Activation of the phototransduction cascade", "R-CFA-4086398:r:Ca2+ pathway", "R-DDI-418555:r:G alpha (s) signalling events", "R-HSA-180024:r:DARPP-32 events", "R-DDI-165160:r:PDE3B signalling", "R-DDI-2485179:r:Activation of the phototransduction cascade", "R-DME-111957:r:Cam-PDE 1 activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-418457:r:cGMP effects", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-PFA-445355:r:Smooth Muscle Contraction", "R-HSA-418555:r:G alpha (s) signalling events", "R-CFA-445355:r:Smooth Muscle Contraction", "R-BTA-111957:r:Cam-PDE 1 activation", "R-DME-180024:r:DARPP-32 events", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-180024:r:DARPP-32 events", "R-BTA-418457:r:cGMP effects", "R-PFA-418555:r:G alpha (s) signalling events", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-418457:r:cGMP effects", "R-RNO-4086398:r:Ca2+ pathway", "R-BTA-445355:r:Smooth Muscle Contraction", "R-CEL-180024:r:DARPP-32 events", "R-CFA-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-418555:r:G alpha (s) signalling events", "R-DDI-445355:r:Smooth Muscle Contraction", "R-RNO-111957:r:Cam-PDE 1 activation", "R-DDI-4086398:r:Ca2+ pathway", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-111957:r:Cam-PDE 1 activation", "R-SCE-165160:r:PDE3B signalling", "R-SCE-418555:r:G alpha (s) signalling events", "R-HSA-165160:r:PDE3B signalling", "R-PFA-165160:r:PDE3B signalling", "R-MMU-418555:r:G alpha (s) signalling events", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DDI-111957:r:Cam-PDE 1 activation", "R-CEL-165160:r:PDE3B signalling", "R-DDI-418457:r:cGMP effects", "R-RNO-418555:r:G alpha (s) signalling events", "R-CEL-111957:r:Cam-PDE 1 activation", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-DME-418555:r:G alpha (s) signalling events", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-165160:r:PDE3B signalling", "R-RNO-165160:r:PDE3B signalling", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-418457:r:cGMP effects", "R-MMU-111957:r:Cam-PDE 1 activation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-418555:r:G alpha (s) signalling events"], "type": "Homologous_superfamily"}, "IPR036972": {"description": "Cytochrome c oxidase, subunit Vb superfamily", "go_ids": ["GO:0005740", "GO:0045277", "GO:0006123"], "go_terms": ["GO:0005740:mitochondrial envelope:C", "GO:0045277:respiratory chain complex IV:C", "GO:0006123:mitochondrial electron transport, cytochrome c to oxygen:P"], "name": "Cyt_c_oxidase_su5b_sf", "pathway_ids": ["R-DDI-9837999", "R-SSC-611105", "R-MMU-9837999", "R-SSC-5628897", "R-RNO-5628897", "R-SSC-9864848", "R-RNO-9707564", "R-RNO-9837999", "R-HSA-5628897", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-SSC-9707564", "R-SPO-9837999", "R-HSA-9707564", "R-SCE-9837999", "R-MMU-5628897", "R-MMU-611105", "R-SSC-9837999", "R-HSA-9837999", "R-MMU-9864848", "R-MMU-9707564"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-SSC-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-SSC-9707564:r:Cytoprotection by HMOX1", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR036973": {"description": "Major capsid L1 (late) superfamily, Papillomavirus", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Capsid_L1_sf_Papillomavir", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036974": {"description": "PUA domain superfamily", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "PUA_sf", "pathway_ids": ["R-MMU-6791226", "R-CEL-171319", "R-RNO-6791226", "R-SPO-171319", "R-HSA-6782315", "R-HSA-6791226", "R-GGA-417076", "R-DME-171319", "R-SCE-171319", "R-DRE-171319", "R-RNO-171319", "R-DDI-171319", "R-HSA-6790901", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-171319:r:Telomere Extension By Telomerase", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-GGA-417076:r:Assembly of telomerase and telomere extension", "R-DME-171319:r:Telomere Extension By Telomerase", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-DDI-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Homologous_superfamily"}, "IPR036975": {"description": "Importin-alpha, importin-beta-binding domain superfamily", "go_ids": ["GO:0006606"], "go_terms": ["GO:0006606:protein import into nucleus:P"], "name": "Importin-a_IBB_sf", "pathway_ids": ["R-HSA-140342", "R-HSA-180910", "R-HSA-9636249", "R-SPO-68616", "R-HSA-442729", "R-HSA-9705671", "R-HSA-168276", "R-BTA-68616", "R-BTA-140342", "R-MMU-5693548", "R-HSA-168271", "R-HSA-9918432", "R-DDI-909733", "R-HSA-1169408", "R-RNO-140342", "R-HSA-68616", "R-MMU-140342", "R-HSA-162592", "R-RNO-68616", "R-HSA-909733", "R-BTA-909733", "R-RNO-909733", "R-HSA-9692916", "R-MMU-68616", "R-HSA-111932", "R-DME-5693548", "R-HSA-5693548", "R-MMU-909733", "R-HSA-9018519"], "pathways": ["R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-162592:r:Integration of provirus", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Homologous_superfamily"}, "IPR036976": {"description": "RimM, N-terminal domain superfamily", "go_ids": ["GO:0006364"], "go_terms": ["GO:0006364:rRNA processing:P"], "name": "RimM_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036977": {"description": "DNA Primase, CHC2-type zinc finger", "go_ids": ["GO:0006260", "GO:0008270", "GO:0003677"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0008270:zinc ion binding:F", "GO:0003677:DNA binding:F"], "name": "DNA_primase_Znf_CHC2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036979": {"description": "Chorismate mutase domain superfamily", "go_ids": ["GO:0046417"], "go_terms": ["GO:0046417:chorismate metabolic process:P"], "name": "CM_dom_sf", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis"], "type": "Homologous_superfamily"}, "IPR036980": {"description": "Ribonuclease P/MRP subunit Rpp29 superfamily", "go_ids": ["GO:0008033", "GO:0003723", "GO:0030677"], "go_terms": ["GO:0008033:tRNA processing:P", "GO:0003723:RNA binding:F", "GO:0030677:ribonuclease P complex:C"], "name": "RNase_P/MRP_Rpp29_sf", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Homologous_superfamily"}, "IPR036982": {"description": "Deoxyhypusine synthase superfamily", "go_ids": ["GO:0008612"], "go_terms": ["GO:0008612:peptidyl-hypusine biosynthetic process:P"], "name": "Deoxyhypusine_synthase_sf", "pathway_ids": ["R-RNO-204626", "R-MMU-204626", "R-HSA-204626", "R-CEL-204626", "R-DDI-204626", "R-DME-204626", "R-SCE-204626", "R-SPO-204626", "R-BTA-204626"], "pathways": ["R-RNO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DDI-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DME-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SCE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-BTA-204626:r:Hypusine synthesis from eIF5A-lysine"], "type": "Homologous_superfamily"}, "IPR036983": {"description": "Mitochondrial biogenesis AIM24 superfamily", "go_ids": [], "go_terms": [], "name": "AIM24_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036984": {"description": "NrpR domain superfamily", "go_ids": [], "go_terms": [], "name": "NrpR_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036985": {"description": "Transglutaminase-like superfamily", "go_ids": [], "go_terms": [], "name": "Transglutaminase-like_sf", "pathway_ids": ["R-SCE-3108214", "R-RNO-6809371", "R-SPO-3108214", "R-HSA-6809371", "R-HSA-3108214", "R-SPO-5696394", "R-RNO-140875", "R-DME-5696395", "R-HSA-6785807", "R-HSA-140875", "R-DME-5696394", "R-RNO-114608", "R-MMU-140875", "R-HSA-114608", "R-MMU-5696395", "R-SPO-5696395", "R-MMU-6809371", "R-HSA-5696395", "R-HSA-5696394", "R-MMU-5696394", "R-MMU-3108214", "R-MMU-114608"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage 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GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR036986": {"description": "RNA-binding S4 domain superfamily", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "S4_RNA-bd_sf", "pathway_ids": ["R-BTA-975957", "R-HSA-9010553", "R-SPO-9954714", "R-SPO-975957", "R-DME-72706", "R-HSA-72695", "R-CEL-975956", "R-SCE-6791226", "R-SCE-72702", "R-MMU-6791226", "R-HSA-2408557", "R-DRE-9954714", "R-BTA-6791226", "R-BTA-72702", "R-HSA-72706", "R-HSA-72702", "R-RNO-72649", "R-DRE-1799339", "R-CEL-72649", "R-DME-72702", "R-SPO-72689", "R-DDI-72689", "R-CEL-72689", "R-HSA-379726", "R-HSA-9954716", "R-SCE-72706", "R-DDI-6791226", "R-MMU-72689", "R-DME-72649", "R-HSA-156827", "R-HSA-6790901", "R-BTA-72706", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", 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"R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-6791226:r:Major pathway of rRNA processing in the 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(EJC)", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72649:r:Translation initiation complex formation", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR036987": {"description": "SRA-YDG superfamily", "go_ids": [], "go_terms": [], "name": "SRA-YDG_sf", "pathway_ids": ["R-HSA-5334118", "R-MMU-3899300", "R-HSA-9821002", "R-HSA-3899300"], "pathways": ["R-HSA-5334118:r:DNA methylation", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-3899300:r:SUMOylation of transcription cofactors"], "type": "Homologous_superfamily"}, "IPR036988": {"description": "Picornavirus coat protein VP4 superfamily", "go_ids": [], "go_terms": [], "name": "Pico_P1A_sf", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Homologous_superfamily"}, "IPR036990": {"description": "Metallocarboxypeptidase-like, propeptide", "go_ids": [], "go_terms": [], "name": "M14A-like_propep", "pathway_ids": ["R-MMU-977606", "R-HSA-977606", "R-BTA-2022377", "R-RNO-977606", "R-MMU-2022377", "R-RNO-2022377", "R-HSA-9925561", "R-HSA-2022377", "R-BTA-977606"], "pathways": ["R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-BTA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-BTA-977606:r:Regulation of Complement cascade"], "type": "Homologous_superfamily"}, "IPR036991": {"description": "Iron hydrogenase, small subunit superfamily", "go_ids": [], "go_terms": [], "name": "Fe_hydrogenase_ssu_sf", "pathway_ids": ["PWY-6785", "PWY-6759", "PWY-6780"], "pathways": ["PWY-6785:t:hydrogen production VIII", "PWY-6759:t:hydrogen production III", "PWY-6780:t:hydrogen production VI"], "type": "Homologous_superfamily"}, "IPR036994": {"description": "Methyl-coenzyme M reductase, gamma subunit superfamily", "go_ids": ["GO:0015948", "GO:0050524"], "go_terms": ["GO:0015948:methanogenesis:P", "GO:0050524:coenzyme-B sulfoethylthiotransferase activity:F"], "name": "Me_CoM_Rdtase_gsu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036995": {"description": "Methylpurine-DNA glycosylase superfamily", "go_ids": ["GO:0003905", "GO:0003677", "GO:0006284"], "go_terms": ["GO:0003905:alkylbase DNA N-glycosylase activity:F", "GO:0003677:DNA binding:F", "GO:0006284:base-excision repair:P"], "name": "MPG_sf", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-RNO-110331", "R-HSA-110331", "R-HSA-110330", "R-HSA-110357", "R-MMU-110357", "R-MMU-110331", "R-RNO-110357"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-MMU-110331:r:Cleavage of the damaged purine", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1"], "type": "Homologous_superfamily"}, "IPR036996": {"description": "Proteasome activator PA28, N-terminal domain superfamily", "go_ids": ["GO:0008537"], "go_terms": ["GO:0008537:proteasome activator complex:C"], "name": "PA28_N_sf", "pathway_ids": ["R-MMU-9907900", "R-BTA-9912633", "R-BTA-1236978", "R-RNO-9907900", "R-HSA-1236978", "R-HSA-8950505", "R-RNO-1236974", "R-RNO-9912633", "R-HSA-9907900", "R-SSC-9907900", "R-MMU-1236974", "R-HSA-9912633", "R-HSA-1236974", "R-MMU-1236978", "R-BTA-1236974", "R-MMU-9912633", "R-RNO-1236978", "R-BTA-9907900"], "pathways": ["R-MMU-9907900:r:Proteasome assembly", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-9907900:r:Proteasome assembly", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-1236974:r:ER-Phagosome pathway", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-9907900:r:Proteasome assembly", "R-SSC-9907900:r:Proteasome assembly", "R-MMU-1236974:r:ER-Phagosome pathway", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-1236974:r:ER-Phagosome pathway", "R-MMU-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-9907900:r:Proteasome assembly"], "type": "Homologous_superfamily"}, "IPR036997": {"description": "Proteasome activator PA28, C-terminal domain superfamily", "go_ids": ["GO:0008537"], "go_terms": ["GO:0008537:proteasome activator complex:C"], "name": "PA28_C_sf", "pathway_ids": ["R-MMU-9907900", "R-BTA-9912633", "R-BTA-1236978", "R-RNO-9907900", "R-DDI-9907900", "R-DDI-9912633", "R-HSA-1236978", "R-HSA-8950505", "R-RNO-1236974", "R-RNO-9912633", "R-DDI-1236974", "R-DDI-1236978", "R-HSA-9907900", "R-SSC-9907900", "R-MMU-1236974", "R-HSA-9912633", "R-HSA-1236974", "R-MMU-1236978", "R-BTA-1236974", "R-MMU-9912633", "R-RNO-1236978", "R-BTA-9907900"], "pathways": ["R-MMU-9907900:r:Proteasome assembly", "R-BTA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-9907900:r:Proteasome assembly", "R-DDI-9907900:r:Proteasome assembly", "R-DDI-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-1236974:r:ER-Phagosome pathway", "R-RNO-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-DDI-1236974:r:ER-Phagosome pathway", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9907900:r:Proteasome assembly", "R-SSC-9907900:r:Proteasome assembly", "R-MMU-1236974:r:ER-Phagosome pathway", "R-HSA-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-1236974:r:ER-Phagosome pathway", "R-MMU-9912633:r:Antigen processing: Ub, ATP-independent proteasomal degradation", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-9907900:r:Proteasome assembly"], "type": "Homologous_superfamily"}, "IPR036998": {"description": "Porin, LamB-type superfamily", "go_ids": ["GO:0016020", "GO:0034219", "GO:0015288"], "go_terms": ["GO:0016020:membrane:C", "GO:0034219:carbohydrate transmembrane transport:P", "GO:0015288:porin activity:F"], "name": "Porin_LamB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR036999": {"description": "Diol/glycerol dehydratase, large subunit superfamily", "go_ids": ["GO:0016836", "GO:0031419"], "go_terms": ["GO:0016836:hydro-lyase activity:F", "GO:0031419:cobalamin binding:F"], "name": "Diol/glycerol_deHase_lsu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037000": {"description": "Ski-like, DNA-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Ski_DNA-bd_sf", "pathway_ids": ["R-MMU-2173795", "R-HSA-201451", "R-HSA-2173795", "R-MMU-201451"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-201451:r:Signaling by BMP", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-201451:r:Signaling by BMP"], "type": "Homologous_superfamily"}, "IPR037001": {"description": "Ammonia/particulate methane monooxygenase, subunit A superfamily", "go_ids": [], "go_terms": [], "name": "NH3/CH4_mOase_suA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037002": {"description": "Microviridae F protein superfamily", "go_ids": ["GO:0005198"], "go_terms": ["GO:0005198:structural molecule activity:F"], "name": "Microviridae_protein_F_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037003": {"description": "Translocated intimin receptor, central domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Tir_central_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037004": {"description": "Exonuclease VII, small subunit superfamily", "go_ids": ["GO:0006308", "GO:0008855", "GO:0009318"], "go_terms": ["GO:0006308:DNA catabolic process:P", "GO:0008855:exodeoxyribonuclease VII activity:F", "GO:0009318:exodeoxyribonuclease VII complex:C"], "name": "Exonuc_VII_ssu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037005": {"description": "S-ribosylhomocysteinase (LuxS) superfamily", "go_ids": ["GO:0009372", "GO:0005506", "GO:0043768"], "go_terms": ["GO:0009372:quorum sensing:P", "GO:0005506:iron ion binding:F", "GO:0043768:S-ribosylhomocysteine lyase activity:F"], "name": "LuxS_sf", "pathway_ids": ["PWY-6154", "PWY-6151", "PWY-6153"], "pathways": ["PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-6151:t:S-adenosyl-L-methionine salvage I", "PWY-6153:t:autoinducer AI-2 biosynthesis I"], "type": "Homologous_superfamily"}, "IPR037006": {"description": "Histidine kinase CheA-like, homodimeric domain superfamily", "go_ids": ["GO:0006935", "GO:0000155"], "go_terms": ["GO:0006935:chemotaxis:P", "GO:0000155:phosphorelay sensor kinase activity:F"], "name": "CheA-like_homodim_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037007": {"description": "Epstein Barr virus nuclear antigen-1, DNA-binding domain superfamily", "go_ids": ["GO:0003677", "GO:0042025"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0042025:host cell nucleus:C"], "name": "EBNA1_DNA-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037008": {"description": "Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily", "go_ids": ["GO:0008121"], "go_terms": ["GO:0008121:quinol-cytochrome-c reductase activity:F"], "name": "bc1_Rieske_TM_sf", "pathway_ids": ["PWY-7279", "PWY-6692", "PWY-3781", "R-HSA-9865881", "R-DRE-9865881", "R-GGA-9865881", "R-SCE-9865881", "R-CEL-9865881", "R-DME-611105", "R-MMU-9865881", "R-SPO-9865881", "R-SCE-9865878", "R-RNO-611105", "R-HSA-611105", "R-MMU-611105", "R-RNO-9865881", "R-BTA-9865881", "R-SPO-611105", "R-SCE-611105", "R-SSC-9865881", "R-BTA-611105", "R-DME-9865881"], "pathways": ["PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "PWY-6692:t:Fe(II) oxidation", "PWY-3781:t:aerobic respiration I (cytochrome c)", "R-HSA-9865881:r:Complex III assembly", "R-DRE-9865881:r:Complex III assembly", "R-GGA-9865881:r:Complex III assembly", "R-SCE-9865881:r:Complex III assembly", "R-CEL-9865881:r:Complex III assembly", "R-DME-611105:r:Respiratory electron transport", "R-MMU-9865881:r:Complex III assembly", "R-SPO-9865881:r:Complex III assembly", "R-SCE-9865878:r:Complex III assembly", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-9865881:r:Complex III assembly", "R-BTA-9865881:r:Complex III assembly", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-SSC-9865881:r:Complex III assembly", "R-BTA-611105:r:Respiratory electron transport", "R-DME-9865881:r:Complex III assembly"], "type": "Homologous_superfamily"}, "IPR037009": {"description": "mRNA triphosphatase Cet1-like superfamily", "go_ids": ["GO:0004651"], "go_terms": ["GO:0004651:polynucleotide 5'-phosphatase activity:F"], "name": "mRNA_triPase_Cet1_sf", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Homologous_superfamily"}, "IPR037010": {"description": "Vitamin B12-dependent methionine synthase, activation domain superfamily", "go_ids": ["GO:0008705"], "go_terms": ["GO:0008705:methionine synthase activity:F"], "name": "VitB12-dep_Met_synth_activ_sf", "pathway_ids": ["PWY-3841", "PWY-2201", "R-CEL-156581", "R-RNO-1614635", "R-MMU-9013407", "R-CEL-9759218", "R-RNO-9759218", "R-RNO-9013407", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-DDI-1614635", "R-MMU-9759218", "R-MMU-1614635", "R-HSA-156581", "R-HSA-9759218", "R-RNO-156581", "R-HSA-3359467", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["PWY-3841:t:folate transformations II (plants)", "PWY-2201:t:folate transformations I", "R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-156581:r:Methylation", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Homologous_superfamily"}, "IPR037011": {"description": "Phycoerythrin-like alpha chain superfamily", "go_ids": ["GO:0030089"], "go_terms": ["GO:0030089:phycobilisome:C"], "name": "Phycoerythr-like_a_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037012": {"description": "NanQ anomerase/TabA/YiaL superfamily", "go_ids": [], "go_terms": [], "name": "NanQ/TabA/YiaL_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037013": {"description": "Glutathione synthase, substrate-binding domain superfamily", "go_ids": ["GO:0006750", "GO:0004363", "GO:0005524"], "go_terms": ["GO:0006750:glutathione biosynthetic process:P", "GO:0004363:glutathione synthase activity:F", "GO:0005524:ATP binding:F"], "name": "GSH-S_sub-bd_sf", "pathway_ids": ["PWY-8043", "R-RNO-174403", "R-HSA-174403", "R-HSA-5579006", "R-DDI-174403", "R-MMU-174403", "R-SCE-174403", "R-SPO-174403"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-HSA-5579006:r:Defective GSS causes GSS deficiency", "R-DDI-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling"], "type": "Homologous_superfamily"}, "IPR037015": {"description": "Aerolysin/Pertussis toxin (APT), N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "APT_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037017": {"description": "Anthrax toxin, edema factor, central domain superfamily", "go_ids": ["GO:0008294", "GO:0005576"], "go_terms": ["GO:0008294:calcium- and calmodulin-responsive adenylate cyclase activity:F", "GO:0005576:extracellular region:C"], "name": "Anthrax_toxin_edema_cen_sf", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Homologous_superfamily"}, "IPR037018": {"description": "Glycoside hydrolase family 65, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GH65_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037019": {"description": "Glycoside hydrolase family 7, catalytic domain superfamily", "go_ids": ["GO:0005975", "GO:0004553"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "Glyco_hydro_7_cat_sf", "pathway_ids": ["PWY-6788"], "pathways": ["PWY-6788:t:cellulose degradation II (fungi)"], "type": "Homologous_superfamily"}, "IPR037020": {"description": "Hemocyanin, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Hemocyanin_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037021": {"description": "RnfH superfamily", "go_ids": [], "go_terms": [], "name": "RnfH_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037022": {"description": "Formyl transferase, C-terminal domain superfamily", "go_ids": ["GO:0009058"], "go_terms": ["GO:0009058:biosynthetic process:P"], "name": "Formyl_trans_C_sf", "pathway_ids": ["R-RNO-196757", "R-HSA-196757", "R-XTR-196757", "R-MMU-196757"], "pathways": ["R-RNO-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines", "R-XTR-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines"], "type": "Homologous_superfamily"}, "IPR037024": {"description": "[NiFe]-hydrogenase, small subunit, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NiFe_Hase_small_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037025": {"description": "Photosystem II cytochrome b559, alpha subunit superfamily", "go_ids": ["GO:0015979", "GO:0019684", "GO:0009767", "GO:0020037", "GO:0009523"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0019684:photosynthesis, light reaction:P", "GO:0009767:photosynthetic electron transport chain:P", "GO:0020037:heme binding:F", "GO:0009523:photosystem II:C"], "name": "PSII_cyt_b559_asu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037026": {"description": "Vgr protein, OB-fold domain superfamily", "go_ids": [], "go_terms": [], "name": "Vgr_OB-fold_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037027": {"description": "YqgF/RNase H-like domain superfamily", "go_ids": ["GO:0006139"], "go_terms": ["GO:0006139:nucleobase-containing compound metabolic process:P"], "name": "YqgF/RNaseH-like_dom_sf", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Homologous_superfamily"}, "IPR037028": {"description": "Dr-adhesin superfamily", "go_ids": [], "go_terms": [], "name": "Dr_adhesin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037029": {"description": "Alliinase, N-terminal domain superfamily", "go_ids": ["GO:0016846"], "go_terms": ["GO:0016846:carbon-sulfur lyase activity:F"], "name": "Alliinase_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037030": {"description": "Retinal cGMP phosphodiesterase, gamma subunit superfamily", "go_ids": ["GO:0007601", "GO:0030553", "GO:0004114"], "go_terms": ["GO:0007601:visual perception:P", "GO:0030553:cGMP binding:F", "GO:0004114:3',5'-cyclic-nucleotide phosphodiesterase activity:F"], "name": "PDE6_gamma_sf", "pathway_ids": ["R-BTA-2485179", "R-BTA-4086398", "R-HSA-2514859", "R-MMU-2514859", "R-MMU-4086398", "R-HSA-2485179", "R-MMU-2485179", "R-BTA-2514859", "R-HSA-4086398", "R-CFA-2485179", "R-CFA-4086398"], "pathways": ["R-BTA-2485179:r:Activation of the phototransduction cascade", "R-BTA-4086398:r:Ca2+ pathway", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-4086398:r:Ca2+ pathway", "R-CFA-2485179:r:Activation of the phototransduction cascade", "R-CFA-4086398:r:Ca2+ pathway"], "type": "Homologous_superfamily"}, "IPR037031": {"description": "Succinylarginine dihydrolase superfamily", "go_ids": ["GO:0006525", "GO:0009015"], "go_terms": ["GO:0006525:arginine metabolic process:P", "GO:0009015:N-succinylarginine dihydrolase activity:F"], "name": "AstB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037033": {"description": "DNA-directed RNA polymerase, subunit 2, hybrid-binding 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"R-CEL-73762:r:RNA Polymerase I Transcription Initiation", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Homologous_superfamily"}, "IPR037035": {"description": "Glycerate kinase-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "GK-like_C_sf", "pathway_ids": ["R-HSA-70350", "R-BTA-70350", "R-RNO-70350", "R-DME-70350", "R-DRE-70350", "R-CEL-70350", "R-MMU-70350"], "pathways": ["R-HSA-70350:r:Fructose catabolism", "R-BTA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-DME-70350:r:Fructose catabolism", "R-DRE-70350:r:Fructose catabolism", "R-CEL-70350:r:Fructose catabolism", "R-MMU-70350:r:Fructose catabolism"], "type": "Homologous_superfamily"}, "IPR037036": {"description": "GMP phosphodiesterase, delta subunit superfamily", "go_ids": [], "go_terms": [], "name": "PDED_dom_sf", "pathway_ids": ["R-DRE-5624138", "R-HSA-5624958", "R-MMU-5624958", "R-BTA-5624958", "R-MMU-9648002", "R-CFA-9648002", "R-CFA-5624958", "R-MMU-5624138", "R-BTA-9648002", "R-HSA-5624138", "R-HSA-9648002", "R-CEL-5624138", "R-CEL-9648002", "R-DME-9648002"], "pathways": ["R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-BTA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-9648002:r:RAS processing", "R-CFA-9648002:r:RAS processing", "R-CFA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-BTA-9648002:r:RAS processing", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-9648002:r:RAS processing", "R-CEL-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-CEL-9648002:r:RAS processing", "R-DME-9648002:r:RAS processing"], "type": "Homologous_superfamily"}, "IPR037037": {"description": "L-proline 3-hydroxylase, C-terminal domain superfamily", "go_ids": ["GO:0016706"], "go_terms": ["GO:0016706:2-oxoglutarate-dependent dioxygenase activity:F"], "name": "Pro_3_hydrox_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037038": {"description": "tRNA nuclease HepT-like superfamily", "go_ids": [], "go_terms": [], "name": "HepT-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037039": {"description": "Chorismate mutase, AroQ class superfamily, eukaryotic", "go_ids": ["GO:0009073", "GO:0004106"], "go_terms": ["GO:0009073:aromatic amino acid biosynthetic process:P", "GO:0004106:chorismate mutase activity:F"], "name": "CM_AroQ_sf_eucaryotic", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis"], "type": "Homologous_superfamily"}, "IPR037040": {"description": "Cytotoxic necrotizing factor, Rho-activating domain superfamily", "go_ids": [], "go_terms": [], "name": "CNF_Rho-act_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037041": {"description": "Trigger factor, C-terminal domain superfamily", "go_ids": ["GO:0015031", "GO:0006457"], "go_terms": ["GO:0015031:protein transport:P", "GO:0006457:protein folding:P"], "name": "Trigger_fac_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037042": {"description": "Transcriptional regulator YdaT-like superfamily", "go_ids": [], "go_terms": [], "name": "YdaT-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037043": {"description": "Moricin domain superfamily", "go_ids": ["GO:0042742", "GO:0005576"], "go_terms": ["GO:0042742:defense response to bacterium:P", "GO:0005576:extracellular region:C"], "name": "Moricin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037045": {"description": "Peptidase S8 propeptide/proteinase inhibitor I9 superfamily", "go_ids": [], "go_terms": [], "name": "S8pro/Inhibitor_I9_sf", "pathway_ids": ["PWY-7884", "R-RNO-381426", "R-SPO-8964038", "R-HSA-8866427", "R-HSA-381426", "R-RNO-8957275", "R-SPO-8866427", "R-MMU-8866427", "R-MMU-381426", "R-MMU-8964038", "R-HSA-8957275", "R-SCE-8964038", "R-SCE-8866427", "R-RNO-8964038", "R-RNO-8866427", "R-MMU-8957275", "R-HSA-8964038"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SPO-8964038:r:LDL clearance", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8964038:r:LDL clearance", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SCE-8964038:r:LDL clearance", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-RNO-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964038:r:LDL clearance"], "type": "Homologous_superfamily"}, "IPR037046": {"description": "DNA-3-methyladenine glycosylase AlkA, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "AlkA_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037047": {"description": "PITH domain superfamily", "go_ids": [], "go_terms": [], "name": "PITH_dom_sf", "pathway_ids": ["R-HSA-9013420", "R-HSA-9013422", "R-HSA-9013418", "R-HSA-9696270", "R-RNO-9013422", "R-RNO-9696270", "R-MMU-9013424", "R-HSA-9013424", "R-RNO-9696273", "R-RNO-9013420", "R-HSA-9696264", "R-MMU-9013422", "R-MMU-9013420", "R-RNO-9013424", "R-SPO-9696273", "R-SPO-9013424", "R-RNO-9696264", "R-SPO-9013420", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9696273", "R-RNO-9013418", "R-MMU-9013418"], "pathways": ["R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-SPO-9013424:r:RHOV GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR037048": {"description": "KorB, C-terminal domain superfamily", "go_ids": ["GO:0045892", "GO:0003677"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F"], "name": "KorB_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037049": {"description": "Domain of unknown function DUF1214, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DUF1214_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037050": {"description": "Domain of unknown function DUF1254 superfamily", "go_ids": [], "go_terms": [], "name": "DUF1254_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037051": {"description": "Four-carbon acid sugar kinase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "4-carb_acid_sugar_kinase_N_sf", "pathway_ids": ["PWY-7873", "PWY-7874"], "pathways": ["PWY-7873:t:D-erythronate degradation II", "PWY-7874:t:L-threonate degradation"], "type": "Homologous_superfamily"}, "IPR037052": {"description": "Chemotaxis protein CheA, P2 response regulator-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "CheA-like_P2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037053": {"description": "Phage tail collar domain superfamily", "go_ids": [], "go_terms": [], "name": "Phage_tail_collar_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037054": {"description": "Alpha-glucuronidase, C-terminal domain superfamily", "go_ids": ["GO:0045493", "GO:0046559", "GO:0005576"], "go_terms": ["GO:0045493:xylan catabolic process:P", "GO:0046559:alpha-glucuronidase activity:F", "GO:0005576:extracellular region:C"], "name": "A-glucoronidase_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037055": {"description": "MHC class I-like antigen recognition-like superfamily", "go_ids": [], "go_terms": [], "name": "MHC_I-like_Ag-recog_sf", "pathway_ids": ["R-HSA-9610379", "R-HSA-6798695", "R-BTA-140875", "R-HSA-9705671", "R-RNO-198933", "R-MMU-5223345", "R-HSA-2424491", "R-HSA-2172127", "R-MMU-1236977", "R-RNO-140875", "R-HSA-1236977", "R-RNO-5223345", "R-HSA-140875", "R-HSA-164940", "R-BTA-202733", "R-HSA-8866654", "R-HSA-983170", "R-MMU-140875", "R-HSA-163125", "R-MMU-198933", "R-HSA-909733", "R-RNO-202733", "R-MMU-917977", "R-MMU-202733", "R-HSA-877300", "R-MMU-1236974", "R-MMU-983170", "R-HSA-1236974", "R-HSA-198933", "R-MMU-6798695", "R-HSA-917977", "R-HSA-5223345", "R-RNO-917977", "R-HSA-202733"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-2172127:r:DAP12 interactions", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-1236974:r:ER-Phagosome pathway", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Homologous_superfamily"}, "IPR037056": {"description": "Ribonuclease H1, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RNase_H1_N_sf", "pathway_ids": ["R-HSA-9013404", "R-HSA-2995383", "R-HSA-9013408", "R-HSA-9913635"], "pathways": ["R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR037057": {"description": "DNA mismatch repair MutH/Type II restriction endonuclease superfamily", "go_ids": ["GO:0003677", "GO:0004519"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0004519:endonuclease activity:F"], "name": "DNA_rep_MutH/T2_RE_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037058": {"description": "Flagellar hook protein FlgE superfamily", "go_ids": [], "go_terms": [], "name": "Falgellar_hook_FlgE_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037059": {"description": "Rel homology domain (RHD), DNA-binding domain superfamily", "go_ids": ["GO:0006355", "GO:0003677", "GO:0003700"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "RHD_DNA_bind_dom_sf", "pathway_ids": ["R-HSA-9020702", "R-HSA-4755510", "R-HSA-9942503", "R-DDI-8984722", "R-MMU-4086398", "R-MMU-9020702", "R-MMU-3134963", "R-MMU-933542", "R-RNO-2871809", "R-DME-4755510", "R-RNO-193692", "R-HSA-3134963", "R-HSA-5684264", "R-DDI-8854691", "R-DME-214869", "R-MMU-1810476", "R-DME-5676590", "R-DME-214842", "R-GGA-1227892", "R-DDI-9860927", "R-HSA-5607761", "R-MMU-3214841", "R-HSA-9660826", "R-HSA-9609690", "R-RNO-3214841", "R-MMU-448706", "R-MMU-2025928", "R-RNO-5621575", "R-MMU-9860927", "R-RNO-6798695", "R-DME-3134963", "R-DME-202424", "R-HSA-5607763", "R-HSA-933542", "R-RNO-3134963", "R-DDI-3249367", "R-RNO-9860927", "R-MMU-193692", "R-RNO-2025928", "R-DDI-8985947", "R-DME-214416", "R-HSA-4086398", "R-MMU-202424", "R-DDI-9833482", "R-DME-214411", "R-MMU-209560", "R-DME-6798695", "R-HSA-381340", "R-HSA-2871809", "R-MMU-1169091", "R-MMU-5607761", "R-MMU-5676590", "R-DME-445989", "R-HSA-9909649", "R-DDI-9701898", "R-DME-9020702", "R-DME-214399", "R-HSA-6798695", "R-DDI-9008059", "R-DDI-9020591", "R-RNO-9020702", "R-MMU-5607764", "R-DME-209560", "R-DME-5621575", "R-HSA-9818749", "R-HSA-5676590", "R-RNO-448706", "R-DME-933542", "R-DDI-9020933", "R-MMU-445989", "R-RNO-202424", "R-DME-214844", "R-DME-209400", "R-MMU-5684264", "R-HSA-5603029", "R-DDI-6785807", "R-HSA-209560", "R-MMU-5621575", "R-RNO-209560", "R-GGA-434131", "R-HSA-1169091", "R-MMU-2871837", "R-RNO-445989", "R-MMU-6798695", "R-HSA-9860927", "R-DME-5607764", "R-DME-209406", "R-HSA-193692", "R-DME-2871837", "R-DDI-877312", "R-HSA-844456", "R-HSA-445989", "R-RNO-933542", "R-HSA-8853884", "R-DME-1169091", "R-DDI-909733", "R-DME-1810476", "R-HSA-2559582", "R-DME-9860927", "R-HSA-2871837", "R-HSA-2025928", "R-HSA-448706", "R-MMU-5607763", "R-HSA-3214841", "R-HSA-5660668", "R-HSA-8877330", "R-HSA-5621575", "R-DME-5607761", "R-DDI-877300", "R-DME-209394", "R-DDI-9020956", "R-HSA-5607764", "R-RNO-1810476", "R-DDI-1169408", "R-RNO-5684264", "R-DDI-201556", "R-GGA-434001", "R-RNO-5607763", "R-DDI-1059683", "R-DDI-6783783", "R-HSA-1810476", "R-RNO-5607764", "R-HSA-202424", "R-MMU-2871809", "R-RNO-1169091", "R-HSA-9692916", "R-DDI-8983432", "R-MMU-4755510", "R-RNO-2871837"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-DDI-8984722:r:Interleukin-35 Signalling", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-4755510:r:SUMOylation of immune response proteins", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DDI-8854691:r:Interleukin-20 family signaling", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-DDI-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DME-202424:r:Downstream TCR signaling", "R-HSA-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DDI-3249367:r:STAT6-mediated induction of chemokines", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-DDI-8985947:r:Interleukin-9 signaling", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-202424:r:Downstream TCR signaling", "R-DDI-9833482:r:PKR-mediated signaling", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-2871809:r:FCERI mediated Ca+2 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signaling", "R-RNO-448706:r:Interleukin-1 processing", "R-DME-933542:r:TRAF6 mediated NF-kB activation", "R-DDI-9020933:r:Interleukin-23 signaling", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-202424:r:Downstream TCR signaling", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-DME-209400:r:Transcriptional activtion by phosphorylated DL/DIF dimer", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-DDI-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DDI-877312:r:Regulation of IFNG signaling", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-877300:r:Interferon gamma signaling", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-DDI-9020956:r:Interleukin-27 signaling", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DDI-201556:r:Signaling by ALK", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-DDI-1059683:r:Interleukin-6 signaling", "R-DDI-6783783:r:Interleukin-10 signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DDI-8983432:r:Interleukin-15 signaling", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Homologous_superfamily"}, "IPR037062": {"description": "Malic enzyme, N-terminal domain superfamily", "go_ids": ["GO:0016616", "GO:0004470"], "go_terms": ["GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F", "GO:0004470:malic enzyme activity:F"], "name": "Malic_N_dom_sf", "pathway_ids": ["PWY-3641", "PWY-7115", "PWY-7384", "PWY-7686", "PWY-7118", "R-MMU-70268", "R-HSA-1989781", "R-HSA-9818025", "R-MMU-9837999", "R-RNO-70268", "R-MMU-9861718", "R-HSA-9837999", "R-RNO-9861718", "R-HSA-70268", "R-HSA-9861718"], "pathways": ["PWY-3641:t:L-carnitine degradation II", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-7686:t:L-malate degradation II", "PWY-7118:t:chitin deacetylation", "R-MMU-70268:r:Pyruvate metabolism", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9818025:r:NFE2L2 regulating TCA cycle genes", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-70268:r:Pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism"], "type": "Homologous_superfamily"}, "IPR037063": {"description": "Bacterial Pleckstrin homology domain superfamily", "go_ids": [], "go_terms": [], "name": "PHb_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037064": {"description": "Formiminotransferase, N-terminal subdomain superfamily", "go_ids": ["GO:0016740", "GO:0005542"], "go_terms": ["GO:0016740:transferase activity:F", "GO:0005542:folic acid binding:F"], "name": "Formiminotransferase_N_sf", "pathway_ids": ["PWY-5030", "R-MMU-70921", "R-RNO-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Homologous_superfamily"}, "IPR037065": {"description": "Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain superfamily", "go_ids": ["GO:0006813", "GO:0005249", "GO:0030955", "GO:0016020"], "go_terms": ["GO:0006813:potassium ion transport:P", "GO:0005249:voltage-gated potassium channel activity:F", "GO:0030955:potassium ion binding:F", "GO:0016020:membrane:C"], "name": "K_chnl_volt-dep_Kv1.4_TID_sf", "pathway_ids": ["R-RNO-1296072", "R-HSA-1296072", "R-MMU-1296072"], "pathways": ["R-RNO-1296072:r:Voltage gated Potassium channels", "R-HSA-1296072:r:Voltage gated Potassium channels", "R-MMU-1296072:r:Voltage gated Potassium channels"], "type": "Homologous_superfamily"}, "IPR037066": {"description": "TonB-dependent receptor, plug domain superfamily", "go_ids": [], "go_terms": [], "name": "Plug_dom_sf", "pathway_ids": ["R-HSA-9638334", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Homologous_superfamily"}, "IPR037067": {"description": "Coatomer, gamma subunit, appendage domain superfamily", "go_ids": ["GO:0006886", "GO:0016192", "GO:0005198", "GO:0030126"], "go_terms": ["GO:0006886:intracellular protein transport:P", "GO:0016192:vesicle-mediated transport:P", "GO:0005198:structural molecule activity:F", "GO:0030126:COPI vesicle coat:C"], "name": "Coatomer_gsu_app_sf", "pathway_ids": ["R-SPO-6807878", "R-RNO-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-RNO-6807878", "R-XTR-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-DDI-6811434", "R-CEL-6811434", "R-DME-6811434", "R-BTA-6807878", "R-HSA-6811434", "R-XTR-6811434", "R-DDI-6807878", "R-DRE-6811434", "R-SPO-6811434", "R-DRE-6807878", "R-DME-6807878", "R-BTA-6811434", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-XTR-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-DRE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR037068": {"description": "DNA primase, catalytic core, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DNA_primase_core_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037069": {"description": "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily", "go_ids": ["GO:0016627", "GO:0050660"], "go_terms": ["GO:0016627:oxidoreductase activity, acting on the CH-CH group of donors:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "AcylCoA_DH/ox_N_sf", "pathway_ids": ["R-HSA-1989781", "R-DDI-390247", "R-CEL-71064", "R-HSA-6799198", "R-RNO-6799198", "R-RNO-2046106", "R-DME-77288", "R-DDI-71064", "R-HSA-77346", "R-MMU-77352", "R-RNO-77305", "R-BTA-9033241", "R-CEL-2046106", "R-RNO-9033241", "R-MMU-77346", "R-MMU-389887", "R-DME-77348", "R-RNO-77285", "R-RNO-389887", "R-DDI-193368", "R-RNO-77289", "R-BTA-9837999", "R-HSA-71064", "R-HSA-77352", "R-DDI-9033241", "R-HSA-77289", "R-DME-77346", "R-BTA-70895", "R-MMU-6799198", "R-MMU-77350", "R-DME-389887", "R-HSA-389887", "R-HSA-70895", "R-HSA-77348", "R-BTA-2046106", "R-MMU-77348", "R-BTA-77305", "R-HSA-9914355", "R-HSA-77310", "R-BTA-77346", "R-SSC-77285", "R-HSA-390247", "R-MMU-77289", "R-RNO-193368", "R-MMU-390247", "R-HSA-2046106", "R-MMU-77288", "R-RNO-77352", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-DDI-70895", "R-RNO-77310", "R-HSA-193368", "R-HSA-77350", "R-DME-2046106", "R-HSA-77285", "R-BTA-77288", "R-CEL-193368", "R-SSC-77310", "R-RNO-77350", "R-RNO-77288", "R-DDI-389887", "R-MMU-70895", "R-MMU-77310", "R-RNO-77348", "R-HSA-9837999", "R-HSA-77305", "R-CEL-389887", "R-DME-390247", "R-BTA-71064", "R-DDI-9837999", "R-HSA-381038", "R-MMU-71064", "R-MMU-2046106", "R-MMU-193368", "R-DDI-2046106", "R-DME-9033241", "R-MMU-9033241", "R-RNO-9837999", "R-CEL-390247", "R-MMU-77285", "R-BTA-77348", "R-RNO-70895", "R-SCE-389887", "R-MMU-77305", "R-DME-193368", "R-BTA-390247", "R-HSA-9033500", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-71064:r:Lysine catabolism", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-71064:r:Lysine catabolism", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-BTA-9033241:r:Peroxisomal protein import", "R-CEL-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-71064:r:Lysine catabolism", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-6799198:r:Complex I biogenesis", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-9914355:r:Isovaleric acidemia", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-CEL-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-CEL-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-BTA-71064:r:Lysine catabolism", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-71064:r:Lysine catabolism", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-CEL-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Homologous_superfamily"}, "IPR037070": {"description": "Formiminotransferase, C-terminal subdomain superfamily", "go_ids": ["GO:0016740", "GO:0005542"], "go_terms": ["GO:0016740:transferase activity:F", "GO:0005542:folic acid binding:F"], "name": "Formiminotransferase_C_sf", "pathway_ids": ["PWY-5030", "PWY-5497", "R-MMU-70921", "R-RNO-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Homologous_superfamily"}, "IPR037071": {"description": "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Amyloid_glyco_Abeta_sf", "pathway_ids": ["R-SSC-432720", "R-HSA-879415", "R-SSC-381426", "R-SSC-8957275", "R-HSA-3000178", "R-HSA-432720", "R-HSA-977225", "R-HSA-933542", "R-HSA-9660826", "R-SSC-114608", "R-HSA-8862803", "R-SSC-9609523", "R-HSA-416476", "R-SSC-879415", "R-HSA-114608", "R-HSA-418594", "R-SSC-933542", "R-HSA-444473", "R-SSC-9837999", "R-HSA-8957275", "R-HSA-9837999", "R-HSA-9609523", "R-SSC-445989", "R-HSA-381426", "R-SSC-3000178", "R-HSA-844456", "R-HSA-445989"], "pathways": ["R-SSC-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-SSC-114608:r:Platelet degranulation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-SSC-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-416476:r:G alpha (q) signalling events", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-114608:r:Platelet degranulation", "R-HSA-418594:r:G alpha (i) signalling events", "R-SSC-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation"], "type": "Homologous_superfamily"}, "IPR037073": {"description": "Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily", "go_ids": [], "go_terms": [], "name": "Nuc_rcpt_coact_CREBbp_sf", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-MMU-8941858", "R-RNO-933541", "R-HSA-8936459", "R-RNO-9018519", "R-HSA-9818030", "R-HSA-9616222", "R-HSA-9701898", "R-HSA-9614657", "R-HSA-2122947", "R-MMU-6804760", "R-HSA-9931521", "R-HSA-6804760", "R-RNO-9759194", "R-MMU-3371568", "R-MMU-350054", "R-HSA-6804114", "R-MMU-6804758", "R-HSA-9793380", "R-RNO-9841922", "R-RNO-5621575", "R-HSA-2644606", "R-HSA-9031628", "R-HSA-9768919", "R-HSA-9833109", "R-HSA-8941856", "R-HSA-9705671", "R-MMU-2122947", "R-HSA-9735871", "R-MMU-9759194", "R-MMU-9029569", "R-HSA-3371568", "R-HSA-9818028", "R-HSA-9617629", "R-RNO-400206", "R-MMU-8951936", "R-HSA-9839394", "R-MMU-3899300", "R-RNO-9856649", "R-HSA-210744", "R-HSA-156711", "R-HSA-381340", "R-MMU-8866907", "R-MMU-9701898", "R-HSA-9707616", "R-HSA-6811555", "R-HSA-350054", "R-HSA-201722", "R-HSA-933541", "R-HSA-9909649", "R-RNO-8941856", "R-RNO-8866907", "R-HSA-3214847", "R-HSA-9856649", "R-RNO-9617629", "R-HSA-2426168", "R-MMU-9707564", "R-MMU-9856649", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-1234158", "R-MMU-5689901", "R-MMU-201722", "R-MMU-8939246", "R-HSA-9818749", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-1234158", "R-RNO-350054", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-9018519", "R-HSA-8951936", "R-RNO-3134973", "R-MMU-8936459", "R-MMU-5250924", "R-MMU-5621575", "R-HSA-8941858", "R-MMU-3134973", "R-MMU-9018519", "R-HSA-9013695", "R-HSA-8939243", "R-HSA-9818026", "R-HSA-400206", "R-HSA-3134973", "R-MMU-400206", "R-HSA-5617472", "R-HSA-9818027", "R-HSA-5689901", "R-HSA-9819196", "R-MMU-933541", "R-RNO-201722", "R-HSA-9818035", "R-MMU-9617629", "R-RNO-8939246", "R-HSA-1912408", "R-HSA-6804758", "R-RNO-3371568", "R-HSA-918233", "R-HSA-5621575", "R-HSA-9759194", "R-HSA-9029569", "R-HSA-2173796", "R-HSA-9931509", "R-HSA-8866907", "R-HSA-9013508", "R-HSA-2894862", "R-RNO-9707564", "R-MMU-8939243", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-6803204", "R-HSA-9818032", "R-MMU-8941856", "R-HSA-5250924", "R-MMU-6811555", "R-RNO-1234158", "R-HSA-3899300", "R-HSA-2197563", "R-HSA-8939246"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-3371568:r:Attenuation phase", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-3371568:r:Attenuation phase", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-9839394:r:TGFBR3 expression", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9707616:r:Heme signaling", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-3371568:r:Attenuation phase", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"], "type": "Homologous_superfamily"}, "IPR037074": {"description": "Protein of unknown function DUF1780, putative endonuclease superfamily", "go_ids": [], "go_terms": [], "name": "DUF1780_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037075": {"description": "Formaldehyde-activating enzyme superfamily", "go_ids": ["GO:0016051", "GO:0016840"], "go_terms": ["GO:0016051:carbohydrate biosynthetic process:P", "GO:0016840:carbon-nitrogen lyase activity:F"], "name": "HCHO-activating_enzyme_sf", "pathway_ids": ["PWY-1861", "PWY-1723", "PWY-7796"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1723:t:formaldehyde oxidation VI (H4MPT pathway)", "PWY-7796:t:pentose phosphate pathway (oxidative branch) II"], "type": "Homologous_superfamily"}, "IPR037077": {"description": "Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily", "go_ids": ["GO:0016922", "GO:0006355", "GO:0003713", "GO:0005634"], "go_terms": ["GO:0016922:nuclear receptor binding:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0003713:transcription coactivator activity:F", "GO:0005634:nucleus:C"], "name": "Nuc_rcpt_coact_Ncoa_int_sf", "pathway_ids": 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HMOX1", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DRE-159418:r:Recycling of bile acids and salts", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-211976:r:Endogenous sterols", "R-RNO-211976:r:Endogenous sterols", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-159418:r:Recycling of bile acids and salts", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-211976:r:Endogenous sterols", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "type": "Homologous_superfamily"}, "IPR037078": {"description": "NEDD8-activating enzyme E1 catalytic subunit, C-terminal", "go_ids": ["GO:0045116"], "go_terms": ["GO:0045116:protein neddylation:P"], "name": "NEDD8-ac_enz1_catalyticsu_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037079": {"description": "AF2212/PG0164-like superfamily", "go_ids": [], "go_terms": [], "name": "AF2212/PG0164-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037080": {"description": "Capsid protein VP4 superfamily, Picornavirus", "go_ids": ["GO:0019030"], "go_terms": ["GO:0019030:icosahedral viral capsid:C"], "name": "Capsid_VP4_sf_Picornavirus", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037081": {"description": "Hypothetical protein TM1506", "go_ids": [], "go_terms": [], "name": "Hyp_TM1506", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037082": {"description": "Bacteriophage T4, Gp59, helicase assembly protein, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Phage_T4_Gp59_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037083": {"description": "Type-2 restriction enzyme NgoMIV superfamily", "go_ids": ["GO:0009307", "GO:0009036"], "go_terms": ["GO:0009307:DNA restriction-modification system:P", "GO:0009036:type II site-specific deoxyribonuclease activity:F"], "name": "NgoMIV_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037084": {"description": "Protein-glutamine gamma-glutamyltransferase superfamily", "go_ids": ["GO:0003810"], "go_terms": ["GO:0003810:protein-glutamine gamma-glutamyltransferase activity:F"], "name": "Transglut_prok_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037085": {"description": "Cdc42 binding domain-like superfamily", "go_ids": [], "go_terms": [], "name": "Cdc42-bd-like_dom_sf", "pathway_ids": ["R-RNO-9842663", "R-HSA-9842663", "R-MMU-9842663"], "pathways": ["R-RNO-9842663:r:Signaling by LTK", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-9842663:r:Signaling by LTK"], "type": "Homologous_superfamily"}, "IPR037086": {"description": "D-Lysine 5,6-aminomutase alpha subunit superfamily", "go_ids": [], "go_terms": [], "name": "Lys-AminoMut_asu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037088": {"description": "Vitellinogen, beta-sheet shell domain superfamily", "go_ids": ["GO:0006869", "GO:0005319"], "go_terms": ["GO:0006869:lipid transport:P", "GO:0005319:lipid carrier activity:F"], "name": "Vitellinogen_b-sht_shell_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037089": {"description": "Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Methyl-teptahyd_DH_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037090": {"description": "Glycoside hydrolase families 57, central domain", "go_ids": [], "go_terms": [], "name": "57_glycoside_trans_central", "pathway_ids": ["PWY-622", "PWY-7900", "PWY-5067"], "pathways": ["PWY-622:t:starch biosynthesis", "PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)", "PWY-5067:t:glycogen biosynthesis II (from UDP-D-Glucose)"], "type": "Homologous_superfamily"}, "IPR037091": {"description": "Penicillin-binding protein 4, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Pen-bd_prot4_C_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037092": {"description": "Flavocytochrome c sulphide dehydrogenase, flavin-binding domain superfamily", "go_ids": ["GO:0016491", "GO:0050660"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "FlavoCytC_S_DH_flav-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037093": {"description": "Smaug, PHAT domain superfamily", "go_ids": ["GO:0003723", "GO:0017148", "GO:0030371"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0017148:negative regulation of translation:P", "GO:0030371:translation repressor activity:F"], "name": "PHAT_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037094": {"description": "Glycoside hydrolase family 38, central domain superfamily", "go_ids": ["GO:0006013", "GO:0004559"], "go_terms": ["GO:0006013:mannose metabolic process:P", "GO:0004559:alpha-mannosidase activity:F"], "name": "Glyco_hydro_38_cen_sf", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-MMU-8853383", "R-RNO-8853383", "R-BTA-8853383", "R-HSA-6811438", "R-DME-975578", "R-HSA-975578", "R-HSA-8853383", "R-HSA-9694548", "R-SPO-8853383", "R-MMU-6798695", "R-RNO-975578", "R-BTA-6798695", "R-MMU-975578", "R-DDI-8853383", "R-SCE-8853383"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-BTA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-9694548:r:Maturation of spike protein", "R-SPO-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DDI-8853383:r:Lysosomal oligosaccharide catabolism", "R-SCE-8853383:r:Lysosomal oligosaccharide catabolism"], "type": "Homologous_superfamily"}, "IPR037095": {"description": "RBP-J/Cbf11, DNA binding domain superfamily", "go_ids": ["GO:0006355", "GO:0003677", "GO:0003700", "GO:0005634"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0005634:nucleus:C"], "name": "RBP-J/Cbf11_DNA-bd_sf", "pathway_ids": ["R-HSA-9013508", "R-DME-350054", "R-HSA-8941856", "R-HSA-210744", "R-MMU-2122947", "R-HSA-2894862", "R-HSA-9824272", "R-BTA-8941856", "R-HSA-350054", "R-BTA-350054", "R-HSA-1912408", "R-HSA-9013695", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-2122947"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-DME-350054:r:Notch-HLH transcription pathway", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9824272:r:Somitogenesis", "R-BTA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Homologous_superfamily"}, "IPR037096": {"description": "KCNMB2, ball/chain domain superfamily", "go_ids": [], "go_terms": [], "name": "KCNMB2_ball/chain_dom_sf", "pathway_ids": ["R-HSA-418457", "R-RNO-1296052", "R-HSA-1296052", "R-MMU-1296052"], "pathways": ["R-HSA-418457:r:cGMP effects", "R-RNO-1296052:r:Ca2+ activated K+ channels", "R-HSA-1296052:r:Ca2+ activated K+ channels", "R-MMU-1296052:r:Ca2+ activated K+ channels"], "type": "Homologous_superfamily"}, "IPR037097": {"description": "Photosynthetic reaction centre, H subunit, N-terminal domain superfamily", "go_ids": ["GO:0019684", "GO:0030077"], "go_terms": ["GO:0019684:photosynthesis, light reaction:P", "GO:0030077:plasma membrane light-harvesting complex:C"], "name": "Photo_RC_H_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037099": {"description": "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Fum_R/Succ_DH_flav-like_C_sf", "pathway_ids": ["R-HSA-9854311", "R-SPO-9854311", "R-DRE-9854311", "R-GGA-372987", "R-SSC-9854311", "R-DRE-71403", "R-HSA-611105", "R-RNO-9854311", "R-DME-9854311", "R-SSC-71403", "R-SPO-71403", "R-CEL-71403", "R-MMU-9854311", "R-CEL-9854311", "R-MMU-71403", "R-SCE-71403", "R-XTR-9854311", "R-DME-71403", "R-DDI-9854311", "R-DDI-71403", "R-RNO-71403", "R-XTR-71403", "R-HSA-71403", "R-SCE-9854311"], "pathways": ["R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-SSC-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DRE-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SSC-71403:r:Citric acid cycle (TCA cycle)", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-CEL-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Homologous_superfamily"}, "IPR037100": {"description": "Sporulation initiation phosphotransferase B, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Spo0B_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037101": {"description": "Photosystem I reaction centre subunit PsaK", "go_ids": ["GO:0015979", "GO:0042651", "GO:0009522"], "go_terms": ["GO:0015979:photosynthesis:P", "GO:0042651:thylakoid membrane:C", "GO:0009522:photosystem I:C"], "name": "PSI_PsaK_bact", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037102": {"description": "Zinc finger, large T-antigen D1 domain superfamily", "go_ids": ["GO:0006260", "GO:0003677", "GO:0005524"], "go_terms": ["GO:0006260:DNA replication:P", "GO:0003677:DNA binding:F", "GO:0005524:ATP binding:F"], "name": "Znf_lg_T-Ag_D1_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037103": {"description": "Tubulin/FtsZ-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tubulin/FtsZ-like_C", "pathway_ids": ["R-RNO-190840", "R-HSA-9646399", "R-SSC-3371497", "R-HSA-9833482", "R-XTR-190840", "R-MMU-9668328", "R-RNO-5610787", "R-MMU-68877", "R-DDI-114608", "R-HSA-9668328", "R-MMU-380320", "R-SSC-5620924", "R-SSC-9833482", "R-HSA-6811434", "R-SSC-2132295", "R-XTR-6811434", "R-BTA-2565942", "R-MMU-5610787", "R-RNO-380284", "R-BTA-2500257", "R-SSC-2565942", "R-MMU-5620912", "R-MMU-6811434", "R-DDI-6798695", "R-SSC-8854518", "R-HSA-5620924", "R-MMU-9013407", "R-MMU-380259", "R-XTR-6807878", "R-RNO-9013407", "R-HSA-437239", "R-CEL-6807878", "R-MMU-380270", "R-SSC-5620920", "R-HSA-9609690", "R-CEL-5620924", "R-RNO-5663220", "R-XTR-380320", "R-RNO-6811436", "R-MMU-9646399", "R-BTA-6811436", "R-HSA-8955332", "R-SSC-6807878", "R-HSA-1445148", "R-HSA-389960", "R-RNO-5620924", "R-HSA-389957", "R-BTA-9648025", "R-HSA-9609736", "R-RNO-380270", "R-MMU-5663220", "R-MMU-3371497", "R-RNO-6798695", "R-GGA-6807878", "R-GGA-9646399", "R-DDI-9668328", "R-SSC-6798695", "R-HSA-2467813", "R-MMU-8852276", "R-SCE-6798695", "R-MMU-983189", "R-RNO-3371497", "R-MMU-5620920", "R-HSA-3371497", "R-SSC-5626467", "R-MMU-380284", "R-HSA-114608", "R-BTA-6807878", "R-SSC-5610787", "R-RNO-2565942", "R-HSA-68877", "R-MMU-8955332", "R-MMU-2132295", "R-BTA-380320", "R-XTR-9668328", "R-BTA-2132295", "R-HSA-6811436", "R-SSC-9668328", "R-SSC-9648025", "R-DDI-9833482", "R-GGA-3371497", "R-MMU-437239", "R-DDI-5610787", "R-RNO-2132295", "R-MMU-5626467", "R-DME-6811436", "R-RNO-437239", "R-RNO-68877", "R-XTR-9648025", "R-DME-6798695", "R-RNO-5626467", "R-HSA-380270", "R-XTR-8852276", "R-RNO-380259", "R-XTR-9646399", "R-RNO-9646399", "R-HSA-5663220", "R-RNO-9648025", "R-XTR-8854518", "R-RNO-9833482", "R-XTR-8955332", "R-SSC-5620912", "R-HSA-6798695", "R-SSC-5663220", "R-HSA-190861", "R-RNO-983189", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-BTA-6798695", "R-SSC-190840", "R-HSA-8854518", "R-DDI-5626467", "R-MMU-2565942", "R-RNO-380320", "R-BTA-380259", "R-HSA-380320", "R-MMU-9833482", "R-SSC-9013407", "R-XTR-3371497", "R-GGA-9648025", "R-BTA-5620912", "R-HSA-389977", "R-DME-6807878", "R-MMU-5620924", "R-BTA-9013407", "R-SSC-380259", "R-PFA-9646399", "R-XTR-5620920", "R-HSA-9648025", "R-DDI-8955332", "R-XTR-6798695", "R-XTR-380259", "R-MMU-6811436", "R-GGA-5620924", "R-SSC-380284", "R-HSA-5620920", "R-MMU-8854518", "R-MMU-6798695", "R-BTA-3371497", "R-RNO-2467813", "R-BTA-9646399", "R-GGA-983189", "R-BTA-5620924", "R-XTR-114608", "R-SSC-983189", "R-HSA-9013407", "R-MMU-114608", "R-RNO-9668328", "R-SSC-9646399", "R-SSC-6811434", "R-SPO-6798695", "R-HSA-2132295", "R-SSC-380270", "R-HSA-9619483", "R-HSA-190840", "R-HSA-5626467", "R-RNO-2500257", "R-DDI-5620920", "R-XTR-2467813", "R-SSC-68877", "R-XTR-380270", "R-MMU-6807878", "R-RNO-5620912", "R-GGA-2500257", "R-RNO-114608", "R-HSA-2565942", "R-BTA-114608", "R-BTA-2467813", "R-XTR-5620912", "R-HSA-5610787", "R-SSC-8955332", "R-RNO-8852276", "R-GGA-2467813", "R-MMU-9648025", "R-HSA-5620912", "R-BTA-380284", "R-PFA-3371497", "R-MMU-2500257", "R-GGA-6811436", "R-MMU-190840", "R-HSA-2500257", "R-RNO-6811434", "R-RNO-8854518", "R-RNO-6807878", "R-HSA-6807878", "R-HSA-8852276", "R-CEL-6811436", "R-XTR-5663220", "R-RNO-5620920", "R-HSA-9679191", "R-XTR-380284", "R-XTR-68877", "R-SSC-8852276", "R-SSC-2467813", "R-XTR-983189", "R-BTA-8854518", "R-BTA-380270", "R-DDI-6807878", "R-HSA-983189", "R-XTR-5620924", "R-XTR-2565942", "R-PFA-6798695", "R-SSC-380320", "R-PFA-5620920", "R-RNO-8955332", "R-SSC-2500257", "R-HSA-380259", "R-XTR-2500257", "R-PFA-8955332", "R-GGA-6811434"], "pathways": ["R-RNO-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-9646399:r:Aggrephagy", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9833482:r:PKR-mediated signaling", "R-XTR-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-DDI-114608:r:Platelet degranulation", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-5620924:r:Intraflagellar transport", "R-SSC-9833482:r:PKR-mediated signaling", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SSC-2132295:r:MHC class II antigen presentation", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6798695:r:Neutrophil degranulation", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-6807878:r:COPI-mediated anterograde transport", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-437239:r:Recycling pathway of L1", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SSC-5620920:r:Cargo trafficking to the periciliary membrane", "R-HSA-9609690:r:HCMV Early Events", "R-CEL-5620924:r:Intraflagellar transport", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-389960:r:Formation of tubulin folding intermediates by CCT/TriC", "R-RNO-5620924:r:Intraflagellar transport", "R-HSA-389957:r:Prefoldin mediated transfer of substrate to CCT/TriC", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-6798695:r:Neutrophil degranulation", "R-GGA-6807878:r:COPI-mediated anterograde transport", "R-GGA-9646399:r:Aggrephagy", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-983189:r:Kinesins", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-5620920:r:Cargo trafficking to the periciliary membrane", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SSC-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-114608:r:Platelet degranulation", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-SSC-5610787:r:Hedgehog 'off' state", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-BTA-2132295:r:MHC class II antigen presentation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DDI-9833482:r:PKR-mediated signaling", "R-GGA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-437239:r:Recycling pathway of L1", "R-DDI-5610787:r:Hedgehog 'off' state", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-437239:r:Recycling pathway of L1", "R-RNO-68877:r:Mitotic Prometaphase", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-8852276:r:The role of GTSE1 in G2/M 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{"description": "Valyl-tRNA synthetase, tRNA-binding arm superfamily", "go_ids": [], "go_terms": [], "name": "Val-tRNA_synth_C_sf", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR037119": {"description": "Haem oxygenase HugZ-like superfamily", "go_ids": [], "go_terms": [], "name": "Haem_oxidase_HugZ-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037120": {"description": "Haem peroxidase domain superfamily, animal type", "go_ids": [], "go_terms": [], "name": "Haem_peroxidase_sf_animal", "pathway_ids": ["R-HSA-6798695", "R-MMU-8941413", "R-GGA-9027604", "R-SSC-6798695", "R-HSA-2243919", "R-CEL-6798695", "R-MMU-9027604", "R-MMU-9025094", "R-RNO-9025094", "R-SSC-209968", "R-MMU-2243919", "R-HSA-209968", "R-GGA-9025094", "R-CEL-2243919", "R-BTA-8941413", "R-HSA-9926550", "R-HSA-9027604", "R-HSA-8941413", "R-RNO-9027604", "R-HSA-9018677", "R-HSA-6783783", "R-RNO-140180", "R-MMU-9018677", "R-HSA-2162123", "R-RNO-209968", "R-GGA-9018679", "R-GGA-2162123", "R-DDI-6798695", "R-RNO-2162123", "R-MMU-2162123", "R-HSA-9018679", "R-DME-6798695", "R-DDI-8941413", "R-RNO-2142770", "R-HSA-6785807", "R-GGA-2142770", "R-MMU-2142770", "R-CFA-2162123", "R-CFA-209968", "R-DME-8941413", "R-DME-209968", "R-HSA-140180", "R-CFA-140180", "R-GGA-9018677", "R-HSA-9025094", "R-MMU-9018679", "R-CEL-8941413", "R-MMU-140180", "R-RNO-9018677", "R-MMU-209968", "R-MMU-6798695", "R-HSA-2142770", "R-RNO-9018679", "R-CEL-209968"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-GGA-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-MMU-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-RNO-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-SSC-209968:r:Thyroxine biosynthesis", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-HSA-209968:r:Thyroxine biosynthesis", "R-GGA-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-CEL-2243919:r:Crosslinking of collagen fibrils", "R-BTA-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-HSA-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-RNO-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-HSA-9018677:r:Biosynthesis of DHA-derived SPMs", "R-HSA-6783783:r:Interleukin-10 signaling", "R-RNO-140180:r:COX reactions", "R-MMU-9018677:r:Biosynthesis of DHA-derived SPMs", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-RNO-209968:r:Thyroxine biosynthesis", "R-GGA-9018679:r:Biosynthesis of EPA-derived SPMs", "R-GGA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-9018679:r:Biosynthesis of EPA-derived SPMs", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-RNO-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-MMU-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-CFA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-CFA-209968:r:Thyroxine biosynthesis", "R-DME-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-DME-209968:r:Thyroxine biosynthesis", "R-HSA-140180:r:COX reactions", "R-CFA-140180:r:COX reactions", "R-GGA-9018677:r:Biosynthesis of DHA-derived SPMs", "R-HSA-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-MMU-9018679:r:Biosynthesis of EPA-derived SPMs", "R-CEL-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-MMU-140180:r:COX reactions", "R-RNO-9018677:r:Biosynthesis of DHA-derived SPMs", "R-MMU-209968:r:Thyroxine biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-RNO-9018679:r:Biosynthesis of EPA-derived SPMs", "R-CEL-209968:r:Thyroxine biosynthesis"], "type": "Homologous_superfamily"}, "IPR037121": {"description": "Large ribosomal subunit protein bL25, C-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL25_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037122": {"description": "Pleiotrophin/Midkine, N-terminal domain superfamily", "go_ids": ["GO:0008083"], "go_terms": ["GO:0008083:growth factor activity:F"], "name": "PTN/MK_N_dom_sf", "pathway_ids": ["R-RNO-201556", "R-MMU-201556", "R-XTR-2979096", "R-HSA-2979096", "R-BTA-201556", "R-SSC-9851151", "R-GGA-9851151", "R-HSA-201556", "R-RNO-9851151", "R-XTR-201556", "R-GGA-201556", "R-MMU-9851151", "R-SSC-201556", "R-BTA-9851151", "R-XTR-9851151", "R-HSA-9851151"], "pathways": ["R-RNO-201556:r:Signaling by ALK", "R-MMU-201556:r:Signaling by ALK", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-BTA-201556:r:Signaling by ALK", "R-SSC-9851151:r:MDK and PTN in ALK signaling", "R-GGA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-201556:r:Signaling by ALK", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-XTR-201556:r:Signaling by ALK", "R-GGA-201556:r:Signaling by ALK", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-SSC-201556:r:Signaling by ALK", "R-BTA-9851151:r:MDK and PTN in ALK signaling", "R-XTR-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9851151:r:MDK and PTN in ALK signaling"], "type": "Homologous_superfamily"}, "IPR037123": {"description": "Phosphoribosylglycinamide synthetase, C-domain superfamily", "go_ids": ["GO:0009113", "GO:0004637"], "go_terms": ["GO:0009113:purine nucleobase biosynthetic process:P", "GO:0004637:phosphoribosylamine-glycine ligase activity:F"], "name": "PRibGlycinamide_synth_C_sf", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-BTA-73817", "R-MMU-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817", "R-GGA-419140"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-419140:r:De novo synthesis of IMP"], "type": "Homologous_superfamily"}, "IPR037124": {"description": "GroES chaperonin superfamily", "go_ids": ["GO:0006457"], "go_terms": ["GO:0006457:protein folding:P"], "name": "Chaperonin_GroES_sf", "pathway_ids": ["R-BTA-9013408", "R-HSA-9841251", "R-RNO-9013408", "R-MMU-9013408", "R-HSA-9013408"], "pathways": ["R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-RNO-9013408:r:RHOG GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle"], "type": "Homologous_superfamily"}, "IPR037125": {"description": "Lipoprotein YajI-like superfamily", "go_ids": [], "go_terms": [], "name": "YajI-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037126": {"description": "PdaC/RsiV-like superfamily", "go_ids": [], "go_terms": [], "name": "PdaC/RsiV-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037128": {"description": "Quinolinate phosphoribosyl transferase, N-terminal domain superfamily", "go_ids": ["GO:0016763"], "go_terms": ["GO:0016763:pentosyltransferase activity:F"], "name": "Quinolinate_PRibosylTase_N_sf", "pathway_ids": ["PWY-7342", "PWY-8277", "PWY-5653", "PWY-5316", "PWY-8352", "R-MMU-196807", "R-HSA-196807", "R-DDI-196807", "R-RNO-196807", "R-SSC-196807", "R-SCE-196807"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-8277:t:NAD de novo biosynthesis IV (anaerobic)", "PWY-5653:t:NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde", "PWY-5316:t:nicotine biosynthesis", "PWY-8352:t:NAD de novo biosynthesis III", "R-MMU-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-196807:r:Nicotinate metabolism", "R-SSC-196807:r:Nicotinate metabolism", "R-SCE-196807:r:Nicotinate metabolism"], "type": "Homologous_superfamily"}, "IPR037129": {"description": "XPA domain superfamily", "go_ids": [], "go_terms": [], "name": "XPA_sf", "pathway_ids": ["R-SPO-5696395", "R-MMU-5696395", "R-MMU-6781823", "R-GGA-353303", "R-SPO-5696400", "R-DME-5696400", "R-MMU-6782135", "R-DME-6781823", "R-HSA-5696395", "R-HSA-5696400", "R-HSA-6782135", "R-SPO-6782135", "R-DME-5696395", "R-DME-6782135", "R-MMU-5696400", "R-HSA-6781823", "R-SCE-6782135"], "pathways": ["R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-353303:r:Nucleotide Excision Repair", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Homologous_superfamily"}, "IPR037130": {"description": "Copper metallothionein superfamily", "go_ids": ["GO:0010273", "GO:0071585", "GO:0005507", "GO:0046870"], "go_terms": ["GO:0010273:detoxification of copper ion:P", "GO:0071585:detoxification of cadmium ion:P", "GO:0005507:copper ion binding:F", "GO:0046870:cadmium ion binding:F"], "name": "Cup1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037131": {"description": "Homeo-prospero domain superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Homeo_prospero_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037132": {"description": "Protein N-terminal glutamine amidohydrolase, alpha beta roll superfamily", "go_ids": ["GO:0016811"], "go_terms": ["GO:0016811:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides:F"], "name": "N_Gln_amidohydro_ab_roll_sf", "pathway_ids": ["PWY-7799"], "pathways": ["PWY-7799:t:Arg/N-end rule pathway (eukaryotic)"], "type": "Homologous_superfamily"}, "IPR037133": {"description": "Tetrahydrodipicolinate-N-succinyltransferase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "THP_succinylTrfase_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037135": {"description": "DUF1653-like domain superfamily", "go_ids": [], "go_terms": [], "name": "DUF1653-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037136": {"description": "RNA 3'-terminal phosphate cyclase domain superfamily", "go_ids": [], "go_terms": [], "name": "RNA3'_phos_cyclase_dom_sf", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Homologous_superfamily"}, "IPR037137": {"description": "Cucumovirus coat protein, subunit A superfamily", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Cucumovirus_coat_Asu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037138": {"description": "Histone deacetylase domain superfamily", "go_ids": [], "go_terms": [], "name": "His_deacetylse_dom_sf", "pathway_ids": ["R-MMU-2173795", "R-BTA-9824594", "R-HSA-9646399", "R-HSA-9022692", "R-GGA-8936459", "R-HSA-8936459", "R-HSA-427413", "R-MMU-3214815", "R-BTA-201722", "R-CEL-9701898", "R-DRE-2467813", "R-DRE-400206", "R-RNO-9018519", "R-RNO-8936459", "R-BTA-9018519", "R-MMU-1538133", "R-RNO-9825892", "R-MMU-4551638", "R-SPO-3214815", "R-HSA-9844594", "R-RNO-983231", "R-GGA-8943724", "R-MMU-3371511", "R-DME-9764725", "R-GGA-1538133", "R-HSA-4090294", "R-BTA-2173795", "R-HSA-9824594", "R-HSA-2122947", "R-HSA-9701898", "R-RNO-4090294", "R-MMU-9824594", "R-HSA-9022537", "R-HSA-983231", "R-BTA-4551638", "R-DDI-3371511", "R-HSA-9764725", "R-HSA-9609690", "R-DME-1538133", "R-GGA-983231", "R-MMU-9646399", "R-MMU-381340", "R-RNO-9764725", "R-RNO-8951936", "R-MMU-350054", "R-MMU-6804758", "R-RNO-9841922", "R-HSA-2644606", "R-DRE-9707564", "R-MMU-3108214", "R-DDI-3108214", "R-DDI-3214815", "R-HSA-8941284", "R-BTA-9701898", "R-DME-9701898", "R-CEL-8951936", "R-BTA-6804758", "R-DME-350054", "R-HSA-2467813", "R-GGA-4090294", "R-BTA-9764725", "R-MMU-5620920", "R-GGA-9018519", "R-BTA-983231", "R-DME-3214815", "R-HSA-2173795", "R-CEL-3108214", "R-DME-9824594", "R-MMU-9841922", "R-HSA-1538133", "R-HSA-9615710", "R-MMU-4090294", "R-MMU-9029569", "R-BTA-1538133", "R-RNO-9701898", "R-RNO-400206", "R-MMU-8951936", "R-HSA-381340", "R-SPO-4551638", "R-MMU-9701898", "R-HSA-9707616", "R-DDI-2500257", "R-GGA-6804758", "R-HSA-350054", "R-MMU-8943724", "R-HSA-201722", "R-GGA-9701898", "R-HSA-9725371", "R-XTR-3214815", "R-DDI-9701898", "R-HSA-427389", "R-HSA-9856649", "R-RNO-3769402", "R-MMU-9707564", "R-CEL-983231", "R-HSA-1989781", "R-HSA-9022702", "R-DDI-1538133", "R-HSA-2151201", "R-GGA-350054", "R-BTA-3214815", "R-MMU-2467813", "R-MMU-201722", "R-DDI-9646399", "R-DDI-4551638", "R-DRE-3214815", "R-HSA-9841922", "R-RNO-350054", "R-RNO-2173795", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-8943724", "R-CEL-4551638", "R-BTA-9022692", "R-GGA-2173795", "R-BTA-8936459", "R-DME-6804758", "R-HSA-8878166", "R-GGA-3769402", "R-HSA-4551638", "R-HSA-9825892", "R-HSA-9018519", "R-RNO-1538133", "R-HSA-8951936", "R-MMU-8936459", "R-GGA-73762", "R-HSA-193670", "R-RNO-9022692", "R-DME-9018519", "R-XTR-400206", "R-HSA-3214815", "R-SCE-2500257", "R-RNO-73762", "R-DME-3769402", "R-RNO-6804758", "R-HSA-1362277", "R-HSA-5620920", "R-RNO-381340", "R-HSA-400206", "R-HSA-9613829", "R-RNO-2467813", "R-MMU-9825892", "R-MMU-400206", "R-HSA-5617472", "R-HSA-8940973", "R-DME-8943724", "R-HSA-3371511", "R-MMU-73762", "R-RNO-8943724", "R-DME-9825892", "R-HSA-3769402", "R-HSA-69205", "R-RNO-201722", "R-RNO-2500257", "R-HSA-3108214", "R-DDI-5620920", "R-HSA-9022538", "R-HSA-9619665", "R-GGA-4551638", "R-MMU-983231", "R-RNO-3214815", "R-HSA-6804758", "R-RNO-9029569", "R-BTA-9825892", "R-HSA-9615017", "R-CEL-8943724", "R-MMU-9022692", "R-HSA-9845323", "R-DME-983231", "R-GGA-8951936", "R-DME-209394", "R-XTR-9701898", "R-HSA-9029569", "R-HSA-2173796", "R-HSA-9931509", "R-BTA-8943724", "R-GGA-9824594", "R-BTA-73762", "R-MMU-3769402", "R-MMU-2500257", "R-BTA-3769402", "R-HSA-2500257", "R-HSA-390471", "R-GGA-9825892", "R-HSA-4641265", "R-HSA-1362300", "R-DRE-2500257", "R-HSA-2894862", "R-RNO-9707564", "R-HSA-9679191", "R-HSA-73762", "R-MMU-9764725", "R-DME-201722", "R-SCE-3214815", "R-BTA-350054", "R-RNO-4551638", "R-SPO-3371511", "R-SCE-4551638", "R-GGA-9764725", "R-DME-8936459", "R-CEL-9764725", "R-GGA-201722", "R-HSA-9022699", "R-HSA-9843940", "R-RNO-9824594", "R-SCE-3371511"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9646399:r:Aggrephagy", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-GGA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-BTA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-400206:r:Regulation of lipid metabolism by 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"R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-5620920:r:Cargo trafficking to the periciliary membrane", "R-HSA-9022538:r:Loss of MECP2 binding ability to 5mC-DNA", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-GGA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-3214815:r:HDACs deacetylate histones", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-BTA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-8951936:r:RUNX3 regulates p14-ARF", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-XTR-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-BTA-8943724:r:Regulation of PTEN gene transcription", "R-GGA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-GGA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-4641265:r:Repression of WNT target genes", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene 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"R-RNO-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Homologous_superfamily"}, "IPR037140": {"description": "von Hippel-Lindau disease tumour suppressor, beta domain superfamily", "go_ids": [], "go_terms": [], "name": "VHL_beta_dom_sf", "pathway_ids": ["R-RNO-1234176", "R-DME-983168", "R-MMU-3232142", "R-HSA-9694686", "R-HSA-9706019", "R-HSA-8951664", "R-DME-8951664", "R-RNO-9706019", "R-HSA-9682706", "R-MMU-9706019", "R-HSA-983168", "R-CEL-983168", "R-MMU-1234176", "R-HSA-3232142", "R-MMU-8951664", "R-CEL-1234176", "R-CEL-3232142", "R-RNO-8951664", 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"pathway_ids": ["R-HSA-2173788", "R-HSA-3656532", "R-HSA-2173789", "R-HSA-3304356"], "pathways": ["R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer"], "type": "Homologous_superfamily"}, "IPR037146": {"description": "Colicin/pyocin, DNase domain superfamily", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "Colicin/pyocin_DNase_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037147": {"description": "Large ribosomal subunit protein bL28 superfamily", "go_ids": ["GO:0003735"], "go_terms": ["GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_bL28_sf", "pathway_ids": ["R-MMU-5419276", "R-MMU-9937383", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Homologous_superfamily"}, "IPR037148": {"description": "[NiFe]-hydrogenase, small subunit, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NiFe-Hase_small_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037149": {"description": "Protective antigen, heptamerisation domain superfamily", "go_ids": ["GO:0051260"], "go_terms": ["GO:0051260:protein homooligomerization:P"], "name": "PA_heptamer_dom_sf", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Homologous_superfamily"}, "IPR037150": {"description": "Histone-like protein H-NS, C-terminal domain superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "H-NS_C_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037151": {"description": "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily", "go_ids": [], "go_terms": [], "name": "AlkB-like_sf", "pathway_ids": ["R-MMU-73943", "R-XTR-73943", "R-HSA-73943", "R-HSA-112122", "R-DRE-73943", "R-HSA-112126", "R-RNO-73943"], "pathways": ["R-MMU-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-XTR-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-HSA-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-HSA-112122:r:ALKBH2 mediated reversal of alkylation damage", "R-DRE-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-RNO-73943:r:Reversal of alkylation damage by DNA dioxygenases"], "type": "Homologous_superfamily"}, "IPR037152": {"description": "L-asparaginase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "L-asparaginase_N_sf", "pathway_ids": ["R-HSA-8963693", "R-RNO-8963693", "R-MMU-8963693"], "pathways": ["R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-MMU-8963693:r:Aspartate and asparagine metabolism"], "type": "Homologous_superfamily"}, "IPR037153": {"description": "Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase PpnN-like superfamily", "go_ids": [], "go_terms": [], "name": "PpnN-like_sf", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7570", "PWY-2681", "PWY-5316", "PWY-6617", "PWY-7564", "PWY-8106", "PWY-7569"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7570:t:blasticidin S biosynthesis", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-6617:t:adenosine nucleotides degradation III", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7569:t:arginomycin biosynthesis"], "type": "Homologous_superfamily"}, "IPR037154": {"description": "YtpR-like superfamily", "go_ids": [], "go_terms": [], "name": "YtpR-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037155": {"description": "Staphopain proregion superfamily", "go_ids": [], "go_terms": [], "name": "Staphopain_pro_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037156": {"description": "Like-Sm ribonucleoprotein, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Lsm_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037157": {"description": "UDP-N-acetylglucosamine O-acyltransferase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Acetyltransf_C_sf", "pathway_ids": ["PWY-8245", "PWY-8073", "PWY-8283"], "pathways": ["PWY-8245:t:lipid IVA biosynthesis (P. gingivalis)", "PWY-8073:t:lipid IVA biosynthesis (P. putida)", "PWY-8283:t:lipid IVA biosynthesis (generic)"], "type": "Homologous_superfamily"}, "IPR037158": {"description": "Threonine synthase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Thr_synth_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037159": {"description": "DNA-directed RNA polymerase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RNA_POL_N_sf", "pathway_ids": ["R-MMU-9913635", "R-MMU-163282", "R-SPO-163282", "R-HSA-2151201", "R-SCE-163282", "R-HSA-163282", "R-HSA-9913635"], "pathways": ["R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-163282:r:Mitochondrial transcription initiation", "R-SPO-163282:r:Mitochondrial transcription initiation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SCE-163282:r:Mitochondrial transcription initiation", "R-HSA-163282:r:Mitochondrial transcription initiation", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR037160": {"description": "DNA polymerase, thumb domain superfamily", "go_ids": [], "go_terms": [], "name": "DNA_Pol_thumb_sf", "pathway_ids": ["R-BTA-5649702", "R-BTA-110373", "R-MMU-5649702", "R-MMU-5693571", "R-BTA-5689880", "R-DRE-110381", "R-HSA-5689880", "R-DRE-5649702", "R-SCE-110362", "R-RNO-110362", "R-DRE-110373", "R-MMU-110381", "R-HSA-5649702", "R-DRE-110362", "R-RNO-110381", "R-MMU-5689880", "R-MMU-110362", "R-BTA-5651801", "R-BTA-73930", "R-HSA-110373", "R-DRE-5689880", "R-MMU-5651801", "R-HSA-110362", "R-BTA-110381", "R-HSA-5651801", "R-BTA-110362", "R-RNO-5693571", "R-RNO-5689880", "R-RNO-5649702", "R-MMU-110373", "R-HSA-5693571", "R-RNO-73930", "R-HSA-110381", "R-MMU-73930", "R-RNO-5651801", "R-DRE-5651801", "R-DRE-73930", "R-HSA-73930", "R-RNO-110373"], "pathways": ["R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-BTA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-5689880:r:Ub-specific processing proteases", "R-DRE-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-SCE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-BTA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-MMU-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "type": "Homologous_superfamily"}, "IPR037161": {"description": "Semialdehyde dehydrogenase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Semialdehyde_DH-like_C", "pathway_ids": ["PWY-8091", "PWY-8090", "PWY-8092"], "pathways": ["PWY-8091:t:D-apionate degradation I (xylose isomerase family decarboxylase)", "PWY-8090:t:D-apionate degradation II (RLP decarboxylase)", "PWY-8092:t:D-apionate degradation III (RLP transcarboxylase/hydrolase)"], "type": "Homologous_superfamily"}, "IPR037162": {"description": "TRPM, tetramerisation domain superfamily", "go_ids": ["GO:0051262"], "go_terms": ["GO:0051262:protein tetramerization:P"], "name": "TRPM_tetra_sf", "pathway_ids": ["R-DME-3295583", "R-RNO-3295583", "R-HSA-9824594", "R-MMU-3295583", "R-HSA-3295583"], "pathways": ["R-DME-3295583:r:TRP channels", "R-RNO-3295583:r:TRP channels", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-MMU-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Homologous_superfamily"}, "IPR037163": {"description": "Spermidine synthase, tetramerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "Spermidine_synt_N_sf", "pathway_ids": ["R-SPO-351202", "R-MMU-351202", "R-SCE-351202", "R-HSA-351202", "R-DDI-351202", "R-BTA-351202"], "pathways": ["R-SPO-351202:r:Metabolism of polyamines", "R-MMU-351202:r:Metabolism of polyamines", "R-SCE-351202:r:Metabolism of polyamines", "R-HSA-351202:r:Metabolism of polyamines", "R-DDI-351202:r:Metabolism of polyamines", "R-BTA-351202:r:Metabolism of polyamines"], "type": "Homologous_superfamily"}, "IPR037164": {"description": "Satellite virus coat domain superfamily", "go_ids": ["GO:0005198", "GO:0019028"], "go_terms": ["GO:0005198:structural molecule activity:F", "GO:0019028:viral capsid:C"], "name": "Satellite_virus_coat_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037165": {"description": "Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "AldOxase/xan_DH_Mopterin-bd_sf", "pathway_ids": ["R-MMU-9748787", "R-RNO-8851680", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", "R-RNO-74259", "R-GGA-421178", "R-DME-964975", "R-MMU-8851680", "R-HSA-9748787", "R-HSA-74259", "R-RNO-964975", "R-DME-74259", "R-MMU-964975", "R-CEL-964975", "R-DME-9748787", "R-MMU-74259", "R-DDI-964975", "R-RNO-9748787", "R-DDI-74259"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-GGA-421178:r:Urate synthesis", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-74259:r:Purine catabolism", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Homologous_superfamily"}, "IPR037167": {"description": "D-Ala-D-Ala carboxypeptidase, C-terminal domain superfamily", "go_ids": ["GO:0006508", "GO:0009002"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0009002:serine-type D-Ala-D-Ala carboxypeptidase activity:F"], "name": "Peptidase_S11_C_sf", "pathway_ids": ["PWY-6471", "PWY-5265"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)"], "type": "Homologous_superfamily"}, "IPR037168": {"description": "Virulence factor YopE, GAP domain superfamily", "go_ids": [], "go_terms": [], "name": "YopE_GAP_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037169": {"description": "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily", "go_ids": [], "go_terms": [], "name": "Cytochrome_c_oxidase_VIc_sf", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-MMU-9707564", "R-HSA-9707564", "R-MMU-5628897", "R-RNO-5628897", "R-MMU-611105", "R-RNO-9707564", "R-MMU-9864848", "R-BTA-9864848", "R-HSA-5628897", "R-BTA-5628897", "R-BTA-611105", "R-BTA-9707564"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-611105:r:Respiratory electron transport", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Homologous_superfamily"}, "IPR037171": {"description": "NagB/RpiA transferase-like", "go_ids": [], "go_terms": [], "name": "NagB/RpiA_transferase-like", "pathway_ids": ["R-MMU-71336", "R-HSA-72731", "R-HSA-71336", "R-MMU-70171", "R-MMU-9837999", "R-DDI-71336", "R-SPO-72731", "R-PFA-71336", "R-DME-71336", "R-SCE-71336", "R-HSA-1237112", "R-XTR-70171", "R-SCE-72731", "R-MMU-72731", "R-SPO-1237112", "R-MMU-196757", "R-HSA-5659996", "R-HSA-9837999", "R-BTA-72731", "R-MMU-1237112", "R-CEL-71336", "R-SPO-71336", "R-HSA-70171", "R-CEL-1237112", "R-DME-1237112", "R-CEL-196757", "R-DDI-9837999", "R-DDI-77108", "R-MMU-77108", "R-CEL-9837999", "R-BTA-70171", "R-DME-9837999", "R-DME-70171", "R-RNO-72731", "R-XTR-1237112", "R-CEL-70171", "R-RNO-9837999", "R-DDI-70171", "R-RNO-77108", "R-RNO-71336", "R-HSA-196757", "R-DRE-1237112", "R-PFA-5628897", "R-CEL-72731", "R-HSA-77108", "R-RNO-1237112", "R-DDI-72731", "R-SSC-77108", "R-SSC-9837999", "R-SCE-196757", "R-CEL-77108", "R-SPO-196757", "R-DME-77108", "R-HSA-6791461"], "pathways": ["R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-HSA-71336:r:Pentose phosphate pathway", "R-MMU-70171:r:Glycolysis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-DDI-71336:r:Pentose phosphate pathway", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-PFA-71336:r:Pentose phosphate pathway", "R-DME-71336:r:Pentose phosphate pathway", "R-SCE-71336:r:Pentose phosphate pathway", "R-HSA-1237112:r:Methionine salvage pathway", "R-XTR-70171:r:Glycolysis", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-SPO-1237112:r:Methionine salvage pathway", "R-MMU-196757:r:Metabolism of folate and pterines", "R-HSA-5659996:r:RPIA deficiency: failed conversion of R5P to RU5P", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-MMU-1237112:r:Methionine salvage pathway", "R-CEL-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-HSA-70171:r:Glycolysis", "R-CEL-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-CEL-196757:r:Metabolism of folate and pterines", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DDI-77108:r:Utilization of Ketone Bodies", "R-MMU-77108:r:Utilization of Ketone Bodies", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-70171:r:Glycolysis", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DME-70171:r:Glycolysis", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-XTR-1237112:r:Methionine salvage pathway", "R-CEL-70171:r:Glycolysis", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DDI-70171:r:Glycolysis", "R-RNO-77108:r:Utilization of Ketone Bodies", "R-RNO-71336:r:Pentose phosphate pathway", "R-HSA-196757:r:Metabolism of folate and pterines", "R-DRE-1237112:r:Methionine salvage pathway", "R-PFA-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-72731:r:Recycling of eIF2:GDP", "R-HSA-77108:r:Utilization of Ketone Bodies", "R-RNO-1237112:r:Methionine salvage pathway", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-SSC-77108:r:Utilization of Ketone Bodies", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-SCE-196757:r:Metabolism of folate and pterines", "R-CEL-77108:r:Utilization of Ketone Bodies", "R-SPO-196757:r:Metabolism of folate and pterines", "R-DME-77108:r:Utilization of Ketone Bodies", "R-HSA-6791461:r:RPIA deficiency: failed conversion of RU5P to R5P"], "type": "Homologous_superfamily"}, "IPR037172": {"description": "Flavivirus capsid protein C superfamily", "go_ids": [], "go_terms": [], "name": "Flavi_capsidC_sf", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Homologous_superfamily"}, "IPR037174": {"description": "Trimeric adhesin", "go_ids": [], "go_terms": [], "name": "Trimeric_adhesin", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037175": {"description": "Kynurenine formamidase superfamily", "go_ids": ["GO:0006569", "GO:0004061"], "go_terms": ["GO:0006569:L-tryptophan catabolic process:P", "GO:0004061:arylformamidase activity:F"], "name": "KFase_sf", "pathway_ids": ["PWY-6309", "PWY-7717", "PWY-7734", "PWY-7765", "PWY-5651", "PWY-7733"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-5651:t:L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde", "PWY-7733:t:3-hydroxyquinaldate biosynthesis"], "type": "Homologous_superfamily"}, "IPR037176": {"description": "Osmotin/thaumatin-like superfamily", "go_ids": [], "go_terms": [], "name": "Osmotin/thaumatin-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037177": {"description": "Dynein light chain superfamily", "go_ids": ["GO:0007017", "GO:0030286"], "go_terms": ["GO:0007017:microtubule-based process:P", "GO:0030286:dynein complex:C"], "name": "DLC_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-BTA-139910", "R-DME-3371497", "R-MMU-2467813", "R-MMU-1632852", "R-CEL-6798695", "R-HSA-380284", "R-BTA-6798695", "R-DDI-9646399", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-BTA-380259", "R-RNO-380320", "R-HSA-380320", "R-RNO-1632852", "R-BTA-2565942", "R-BTA-5620912", "R-RNO-380284", "R-BTA-2500257", "R-MMU-139910", "R-MMU-5620912", "R-DME-6807878", "R-HSA-139910", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-HSA-141444", "R-MMU-380270", "R-CEL-6807878", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-BTA-177504", "R-BTA-1632852", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-BTA-6811436", "R-HSA-1632852", "R-MMU-8854518", "R-BTA-3371497", "R-MMU-6798695", "R-RNO-2467813", "R-BTA-9646399", "R-DME-1632852", "R-RNO-5620924", "R-BTA-9648025", "R-BTA-5620924", "R-RNO-380270", "R-RNO-6798695", "R-MMU-3371497", "R-MMU-5663220", "R-RNO-141444", "R-SPO-1632852", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-CEL-1632852", "R-SCE-6798695", "R-MMU-111446", "R-RNO-3371497", "R-HSA-3371497", "R-BTA-5663220", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-BTA-6807878", "R-BTA-2467813", "R-RNO-2565942", "R-HSA-68877", "R-MMU-2132295", "R-HSA-111446", "R-BTA-380320", "R-HSA-5620912", "R-MMU-9648025", "R-BTA-380284", "R-BTA-2132295", "R-HSA-6811436", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-BTA-111446", "R-RNO-6807878", "R-RNO-8854518", "R-DME-6798695", "R-RNO-139910", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-HSA-177504", "R-BTA-380270", "R-BTA-8854518", "R-DDI-6807878", "R-MMU-177504", "R-RNO-9646399", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-111446", "R-HSA-380259", "R-BTA-141444"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-BTA-139910:r:Activation of BMF and translocation to mitochondria", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-1632852:r:Macroautophagy", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-9646399:r:Aggrephagy", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-1632852:r:Macroautophagy", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-139910:r:Activation of BMF and translocation to mitochondria", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-139910:r:Activation of BMF and translocation to mitochondria", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-BTA-1632852:r:Macroautophagy", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-BTA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-9646399:r:Aggrephagy", "R-DME-1632852:r:Macroautophagy", "R-RNO-5620924:r:Intraflagellar transport", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SPO-1632852:r:Macroautophagy", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-1632852:r:Macroautophagy", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-111446:r:Activation of BIM and translocation to mitochondria", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-111446:r:Activation of BIM and translocation to mitochondria", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-2132295:r:MHC class II antigen presentation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-BTA-111446:r:Activation of BIM and translocation to mitochondria", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-139910:r:Activation of BMF and translocation to mitochondria", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-RNO-9646399:r:Aggrephagy", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Homologous_superfamily"}, "IPR037178": {"description": "Colicin D, C-terminal domain superfamily", "go_ids": ["GO:0004540"], "go_terms": ["GO:0004540:RNA nuclease activity:F"], "name": "ColicinD_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037179": {"description": "Nucleocapsid protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Nucleocapsid_C", "pathway_ids": ["R-HSA-9694786", "R-HSA-9020702", "R-HSA-9679509", "R-HSA-9705671", "R-HSA-168638", "R-HSA-168928", "R-HSA-9733458", "R-HSA-9683610", "R-HSA-9735871", "R-HSA-9694614", "R-HSA-9735869", "R-HSA-9694635", "R-HSA-9694631", "R-HSA-9755779", "R-HSA-5218920", "R-HSA-909733", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9692916", "R-HSA-166662", "R-HSA-389357", "R-HSA-166663", "R-HSA-9682708", "R-HSA-1257604", "R-HSA-9692914", "R-HSA-9694322", "R-HSA-445989"], "pathways": ["R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9694635:r:Translation of Structural Proteins", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation"], "type": "Homologous_superfamily"}, "IPR037180": {"description": "Hypothetical protein HI_1480", "go_ids": [], "go_terms": [], "name": "HI_1480_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037181": {"description": "Suppressor of fused, N-terminal", "go_ids": [], "go_terms": [], "name": "SUFU_N", "pathway_ids": ["R-HSA-5610780", "R-MMU-5610780", "R-HSA-5610785", "R-MMU-5632684", "R-MMU-5610785", "R-HSA-5610787", "R-MMU-5610787", "R-HSA-5610783", "R-HSA-5632684"], "pathways": ["R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-5632684:r:Hedgehog 'on' state"], "type": "Homologous_superfamily"}, "IPR037185": {"description": "Multidrug transporter EmrE superfamily", "go_ids": [], "go_terms": [], "name": "EmrE-like", "pathway_ids": ["R-HSA-9913143", "R-SPO-727802", "R-SPO-9939291", "R-RNO-9939291", "R-BTA-727802", "R-MMU-5223345", "R-MMU-9939291", "R-SPO-6787639", "R-HSA-727802", "R-DME-727802", "R-HSA-5619037", "R-CEL-4085001", "R-HSA-5663020", "R-CFA-727802", "R-SPO-4085001", "R-CEL-174362", "R-DME-6787639", "R-DRE-9939291", "R-CEL-9939291", "R-MMU-727802", "R-RNO-727802", "R-HSA-5619083", "R-CEL-727802", "R-HSA-5619072", "R-MMU-4085001", "R-HSA-9939291", "R-HSA-4085001", "R-HSA-174362", "R-SSC-9939291", "R-HSA-5223345", "R-BTA-5223345"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-SPO-727802:r:Transport of nucleotide sugars", "R-SPO-9939291:r:Matriglycan biosynthesis on DAG1", "R-RNO-9939291:r:Matriglycan biosynthesis on DAG1", "R-BTA-727802:r:Transport of nucleotide sugars", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-SPO-6787639:r:GDP-fucose biosynthesis", "R-HSA-727802:r:Transport of nucleotide sugars", "R-DME-727802:r:Transport of nucleotide sugars", "R-HSA-5619037:r:Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)", "R-CEL-4085001:r:Sialic acid metabolism", "R-HSA-5663020:r:Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)", "R-CFA-727802:r:Transport of nucleotide sugars", "R-SPO-4085001:r:Sialic acid metabolism", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-DME-6787639:r:GDP-fucose biosynthesis", "R-DRE-9939291:r:Matriglycan biosynthesis on DAG1", "R-CEL-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-727802:r:Transport of nucleotide sugars", "R-RNO-727802:r:Transport of nucleotide sugars", "R-HSA-5619083:r:Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)", "R-CEL-727802:r:Transport of nucleotide sugars", "R-HSA-5619072:r:Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)", "R-MMU-4085001:r:Sialic acid metabolism", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-4085001:r:Sialic acid metabolism", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-SSC-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-BTA-5223345:r:Miscellaneous transport and binding events"], "type": "Homologous_superfamily"}, "IPR037186": {"description": "Minicollagen I, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Minicollagen_I_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037187": {"description": "DksA, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DnaK_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037188": {"description": "Ribosome maturation protein Sdo1/SBDS, central domain superfamily", "go_ids": [], "go_terms": [], "name": "Sdo1/SBDS_central_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037189": {"description": "HBS1-like protein, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "HBS1-like_N_sf", "pathway_ids": ["R-RNO-429958", "R-MMU-9954714", "R-DME-429958", "R-DME-9954714", "R-MMU-429958", "R-HSA-429958", "R-HSA-9954714", "R-RNO-9954714"], "pathways": ["R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "type": "Homologous_superfamily"}, "IPR037190": {"description": "LIS1, N-terminal", "go_ids": [], "go_terms": [], "name": "LIS1_N", "pathway_ids": ["R-RNO-380284", "R-DME-5676590", "R-GGA-5663220", "R-XTR-69601", "R-DRE-5663220", "R-MMU-5620912", "R-MMU-141444", "R-MMU-380259", "R-DRE-69601", "R-HSA-141444", "R-MMU-380270", "R-DRE-380320", "R-HSA-9648025", "R-GGA-5620912", "R-RNO-5663220", "R-XTR-380259", "R-XTR-380320", "R-MMU-6811436", "R-GGA-141444", "R-RNO-6811436", "R-DRE-5684264", "R-DME-69601", "R-MMU-8854518", "R-RNO-2467813", "R-DRE-5607761", "R-DME-5607764", "R-DME-2871837", "R-RNO-380270", "R-MMU-5663220", "R-RNO-141444", "R-DRE-6811436", "R-GGA-8854518", "R-DME-983168", "R-DME-202424", "R-DME-1169091", "R-HSA-2467813", "R-RNO-2500257", "R-XTR-2467813", "R-XTR-380270", "R-RNO-5620912", "R-DME-2565942", "R-MMU-380284", "R-CEL-983168", "R-GGA-2500257", "R-HSA-2565942", "R-DRE-983168", "R-XTR-5620912", "R-RNO-2565942", "R-HSA-68877", "R-DME-5607761", "R-DRE-5676590", "R-SCE-983168", "R-GGA-2467813", "R-HSA-5620912", "R-MMU-9648025", "R-GGA-380259", "R-HSA-6811436", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-GGA-6811436", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-GGA-380270", "R-DRE-2500257", "R-CEL-6811436", "R-XTR-5663220", "R-XTR-380284", "R-GGA-380320", "R-HSA-380270", "R-XTR-68877", "R-XTR-8951664", "R-RNO-380259", "R-CEL-69601", "R-XTR-983168", "R-DRE-2565942", "R-CEL-2565942", "R-XTR-2565942", "R-HSA-5663220", "R-RNO-9648025", "R-HSA-380259", "R-XTR-8854518", "R-XTR-2500257", "R-CEL-8951664", "R-GGA-380284", "R-DRE-1169091", "R-MMU-2467813", "R-DME-8951664", "R-DRE-8951664", "R-GGA-2565942", "R-HSA-380284", "R-MMU-68877", "R-DRE-2467813", "R-DRE-141444", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-XTR-141444", "R-HSA-380320", "R-GGA-9648025"], "pathways": ["R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-XTR-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-DRE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-GGA-8854518:r:AURKA Activation by TPX2", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-202424:r:Downstream TCR signaling", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-GGA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-68877:r:Mitotic Prometaphase", "R-XTR-8951664:r:Neddylation", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-8951664:r:Neddylation", "R-GGA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation"], "type": "Homologous_superfamily"}, "IPR037191": {"description": "VPS9 domain superfamily", "go_ids": [], "go_terms": [], "name": "VPS9_dom_sf", "pathway_ids": ["R-BTA-8856828", "R-MMU-8856828", "R-CEL-8856828", "R-DME-9013149", "R-HSA-8854214", "R-DME-8876198", "R-HSA-8856828", "R-RNO-8876198", "R-RNO-9013149", "R-HSA-8876198", "R-SCE-8876198", "R-HSA-9013149", "R-MMU-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-DME-8856828", "R-BTA-8876198", "R-MMU-9013149", "R-SPO-8876198"], "pathways": ["R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-8854214:r:TBC/RABGAPs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Homologous_superfamily"}, "IPR037192": {"description": "ERO1-like superfamily", "go_ids": [], "go_terms": [], "name": "ERO1-like_sf", "pathway_ids": ["PWY-7533", "R-HSA-3299685", "R-DRE-3299685", "R-CEL-264876", "R-BTA-3299685", "R-MMU-264876", "R-HSA-264876", "R-SSC-3299685", "R-MMU-3299685", "R-RNO-3299685", "R-DME-264876"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-DRE-3299685:r:Detoxification of Reactive Oxygen Species", "R-CEL-264876:r:Insulin processing", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-264876:r:Insulin processing", "R-HSA-264876:r:Insulin processing", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-DME-264876:r:Insulin processing"], "type": "Homologous_superfamily"}, "IPR037193": {"description": "GDNF receptor alpha", "go_ids": [], "go_terms": [], "name": "GDNF_alpha", "pathway_ids": ["R-HSA-9830674", "R-HSA-8853659", "R-RNO-8853659", "R-MMU-8853659", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-419037", "R-HSA-5673001"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8853659:r:RET signaling", "R-RNO-8853659:r:RET signaling", "R-MMU-8853659:r:RET signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-419037:r:NCAM1 interactions", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Homologous_superfamily"}, "IPR037194": {"description": "NS2, N-terminal", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "NS2_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037195": {"description": "Nucleocapsid protein, N-terminal", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Nucleocapsid_N", "pathway_ids": ["R-HSA-9694786", "R-HSA-9020702", "R-HSA-9679509", "R-HSA-9705671", "R-HSA-168638", "R-HSA-168928", "R-HSA-9733458", "R-HSA-9683610", "R-HSA-9735871", "R-HSA-9694614", "R-HSA-9735869", "R-HSA-9694635", "R-HSA-9694631", "R-HSA-9755779", "R-HSA-5218920", "R-HSA-909733", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9692916", "R-HSA-166662", "R-HSA-389357", "R-HSA-166663", "R-HSA-9682708", "R-HSA-1257604", "R-HSA-9692914", "R-HSA-9694322", "R-HSA-445989"], "pathways": ["R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9694635:r:Translation of Structural Proteins", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-HSA-9755779:r:SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-166663:r:Initial triggering of complement", 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Axon repulsion", "R-BTA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SCE-203615:r:eNOS activation", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DDI-8939211:r:ESR-mediated signaling", "R-CEL-8937144:r:Aryl hydrocarbon receptor signalling", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-844456:r:The NLRP3 inflammasome", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-3371511:r:HSF1 activation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-SPO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DRE-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-MMU-203615:r:eNOS activation", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-3371568:r:Attenuation phase", "R-BTA-399954:r:Sema3A PAK dependent Axon repulsion", "R-BTA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CFA-8957275:r:Post-translational protein phosphorylation", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DRE-8939211:r:ESR-mediated signaling", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling", "R-CFA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-DRE-3371511:r:HSF1 activation", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-3371511:r:HSF1 activation", "R-MMU-844456:r:The NLRP3 inflammasome", "R-SSC-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-SSC-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-SPO-203615:r:eNOS activation", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-3371511:r:HSF1 activation", "R-BTA-8937144:r:Aryl hydrocarbon receptor signalling", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-CFA-1679131:r:Trafficking and processing of endosomal TLR", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-RNO-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-SCE-3371511:r:HSF1 activation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8939211:r:ESR-mediated signaling", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Homologous_superfamily"}, "IPR037197": {"description": "WWE domain superfamily", "go_ids": [], "go_terms": [], "name": "WWE_dom_sf", "pathway_ids": ["R-BTA-983168", "R-DME-2122948", "R-RNO-201681", "R-HSA-6798695", "R-HSA-201681", "R-RNO-8948751", "R-HSA-1606341", "R-HSA-2122948", "R-BTA-5689880", "R-HSA-6802952", "R-HSA-5689880", "R-MMU-2122948", "R-BTA-201681", "R-XTR-8948751", "R-MMU-8948751", "R-DRE-983168", "R-MMU-5689880", "R-RNO-4641257", "R-HSA-4641257", "R-HSA-3270619", "R-BTA-8948751", "R-MMU-3270619", "R-DRE-8948751", "R-HSA-9683610", "R-MMU-3134975", "R-HSA-196807", "R-MMU-201681", "R-HSA-983168", "R-RNO-5689880", "R-HSA-9694631", "R-MMU-4641257", "R-HSA-3134975", "R-MMU-983168", "R-HSA-8948751", "R-BTA-4641257", "R-MMU-6798695", "R-RNO-983168", "R-RNO-6798695"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-XTR-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-4641257:r:Degradation of AXIN", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-MMU-4641257:r:Degradation of AXIN", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR037198": {"description": "MutL, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MutL_C_sf", "pathway_ids": ["R-GGA-5358565", "R-HSA-5545483", "R-SCE-5358565", "R-SPO-5358565", "R-HSA-912446", "R-HSA-5358606", "R-HSA-5358565", "R-DDI-5358565", "R-HSA-6796648", "R-MMU-5358565", "R-HSA-5632987"], "pathways": ["R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632987:r:Defective Mismatch Repair Associated With PMS2"], "type": "Homologous_superfamily"}, "IPR037199": {"description": "Phosphoprotein, C-terminal", "go_ids": ["GO:0003968", "GO:0019083"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F", "GO:0019083:viral transcription:P"], "name": "PP_M1_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037200": {"description": "Pre-mRNA-splicing factor Isy1 superfamily", "go_ids": ["GO:0000350"], "go_terms": ["GO:0000350:generation of catalytic spliceosome for second transesterification step:P"], "name": "Isy1_sf", "pathway_ids": ["R-DDI-6782135", "R-RNO-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-72163", "R-RNO-6782135", "R-DDI-6781823", "R-RNO-72163", "R-DDI-6782210", "R-HSA-6782135", "R-CEL-6782210", "R-DDI-72163", "R-HSA-6781823", "R-CEL-6781823", "R-RNO-6782210", "R-HSA-72163", "R-MMU-6781823", "R-SPO-6782210", "R-CEL-6782135", "R-HSA-6782210", "R-MMU-6782210", "R-SPO-6782135", "R-CEL-72163", "R-SCE-6782210", "R-SPO-72163", "R-HSA-9918481", "R-SCE-6782135"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Homologous_superfamily"}, "IPR037201": {"description": "Calcyclin-binding protein, N-terminal", "go_ids": [], "go_terms": [], "name": "CacyBP_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037202": {"description": "ESCRT assembly domain", "go_ids": [], "go_terms": [], "name": "ESCRT_assembly_dom", "pathway_ids": ["R-HSA-9610379", "R-HSA-917729", "R-RNO-917729", "R-CEL-917729", "R-MMU-917729", "R-HSA-9918476", "R-HSA-174490", "R-HSA-9615710", "R-DDI-917729", "R-BTA-917729", "R-HSA-162588", "R-DME-917729"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-9615710:r:Late endosomal microautophagy", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Homologous_superfamily"}, "IPR037203": {"description": "Type III secretion, needle-protein-like superfamily", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "T3SS_needle-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037204": {"description": "Non-structural protein NSP7 superfamily, coronavirus", "go_ids": ["GO:0016740", "GO:0004197", "GO:0008242"], "go_terms": ["GO:0016740:transferase activity:F", "GO:0004197:cysteine-type endopeptidase activity:F", "GO:0008242:omega peptidase activity:F"], "name": "NSP7_sf_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR037205": {"description": "ChaB superfamily", "go_ids": [], "go_terms": [], "name": "ChaB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037206": {"description": "VPS28, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "VPS28_C_sf", "pathway_ids": ["R-RNO-917729", "R-CEL-917729", "R-HSA-9610379", "R-HSA-917729", "R-MMU-917729", "R-HSA-174490", "R-HSA-9615710", "R-DDI-917729", "R-BTA-917729", "R-HSA-162588", "R-DME-917729"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-9615710:r:Late endosomal microautophagy", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Homologous_superfamily"}, "IPR037207": {"description": "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Nuop51_4Fe4S-bd_sf", "pathway_ids": ["R-DDI-9837999", "R-HSA-611105", "R-MMU-9837999", "R-SPO-9837999", "R-HSA-6799198", "R-MMU-6799198", "R-MMU-611105", "R-HSA-9837999", "R-DDI-6799198"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-6799198:r:Complex I biogenesis"], "type": "Homologous_superfamily"}, "IPR037208": {"description": "Aspartyl-phosphate phosphatase Spo0E-like superfamily", "go_ids": ["GO:0043937"], "go_terms": ["GO:0043937:regulation of sporulation:P"], "name": "Spo0E-like_sf", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Homologous_superfamily"}, "IPR037209": {"description": "RNA-binding protein B2 superfamily", "go_ids": [], "go_terms": [], "name": "RNA-bd_B2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037210": {"description": "YoaC-like superfamily", "go_ids": [], "go_terms": [], "name": "YoaC-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037211": {"description": "Bacteriophage DNA replication protein Gp16.7 superfamily", "go_ids": ["GO:0039693"], "go_terms": ["GO:0039693:viral DNA genome replication:P"], "name": "Phage_DNA_replic_GP16.7_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037212": {"description": "Mediator complex, subunit Med7/Med21-like", "go_ids": ["GO:0016592"], "go_terms": ["GO:0016592:mediator complex:C"], "name": "Med7/Med21-like", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Homologous_superfamily"}, "IPR037213": {"description": "RUN domain superfamily", "go_ids": [], "go_terms": [], "name": "Run_dom_sf", "pathway_ids": ["R-RNO-8876198", "R-HSA-8876198", "R-MMU-8876198", "R-HSA-1660499", "R-MMU-1660499"], "pathways": ["R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Homologous_superfamily"}, "IPR037214": {"description": "TROVE domain superfamily", "go_ids": [], "go_terms": [], "name": "TROVE_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037215": {"description": "GUN4-like superfamily", "go_ids": [], "go_terms": [], "name": "GUN4-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037216": {"description": "DNA terminal protein Gp3 superfamily", "go_ids": [], "go_terms": [], "name": "DNA_terminal_Gp3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037217": {"description": "Tryptophan/Indoleamine 2,3-dioxygenase-like", "go_ids": ["GO:0006569", "GO:0020037", "GO:0046872"], "go_terms": ["GO:0006569:L-tryptophan catabolic process:P", "GO:0020037:heme binding:F", "GO:0046872:metal ion binding:F"], "name": "Trp/Indoleamine_2_3_dOase-like", "pathway_ids": ["R-HSA-71240", "R-CEL-71240", "R-DRE-71240", "R-SCE-71240", "R-XTR-71240", "R-MMU-71240", "R-DDI-71240", "R-DME-71240", "R-RNO-71240", "R-BTA-71240"], "pathways": ["R-HSA-71240:r:Tryptophan catabolism", "R-CEL-71240:r:Tryptophan catabolism", "R-DRE-71240:r:Tryptophan catabolism", "R-SCE-71240:r:Tryptophan catabolism", "R-XTR-71240:r:Tryptophan catabolism", "R-MMU-71240:r:Tryptophan catabolism", "R-DDI-71240:r:Tryptophan catabolism", "R-DME-71240:r:Tryptophan catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-BTA-71240:r:Tryptophan catabolism"], "type": "Homologous_superfamily"}, "IPR037218": {"description": "PTPA superfamily", "go_ids": ["GO:0019211"], "go_terms": ["GO:0019211:phosphatase activator activity:F"], "name": "PTPA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037219": {"description": "Peptidase M41-like", "go_ids": ["GO:0004176", "GO:0006508", "GO:0004222", "GO:0005524"], "go_terms": ["GO:0004176:ATP-dependent peptidase activity:F", "GO:0006508:proteolysis:P", "GO:0004222:metalloendopeptidase activity:F", "GO:0005524:ATP binding:F"], "name": "Peptidase_M41-like", "pathway_ids": ["PWY-8119", "R-HSA-9840373", "R-MMU-9837999", "R-CEL-9837999", "R-BTA-8949664", "R-DME-9837999", "R-SPO-9840373", "R-RNO-9840373", "R-RNO-9837999", "R-MMU-8949664", "R-SCE-9840373", "R-SPO-9837999", "R-BTA-9837999", "R-SCE-9837999", "R-DME-8949664", "R-CEL-8949664", "R-HSA-8949664", "R-HSA-9837999", "R-RNO-8949664", "R-MMU-9840373"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-BTA-8949664:r:Processing of SMDT1", "R-DME-9837999:r:Mitochondrial protein degradation", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-8949664:r:Processing of SMDT1", "R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-8949664:r:Processing of SMDT1", "R-CEL-8949664:r:Processing of SMDT1", "R-HSA-8949664:r:Processing of SMDT1", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-8949664:r:Processing of SMDT1", "R-MMU-9840373:r:Cellular response to mitochondrial stress"], "type": "Homologous_superfamily"}, "IPR037221": {"description": "H-type lectin domain superfamily", "go_ids": [], "go_terms": [], "name": "H-type_lectin_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037222": {"description": "GatD, N-terminal superfamily", "go_ids": [], "go_terms": [], "name": "GatD_N_sf", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Homologous_superfamily"}, "IPR037223": {"description": "Protein 9b, SARS-CoV", "go_ids": [], "go_terms": [], "name": "Protein_9b_SARS", "pathway_ids": ["R-HSA-9727281", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9679504", "R-HSA-9692916"], "pathways": ["R-HSA-9727281:r:Translation of Accessory Proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Homologous_superfamily"}, "IPR037224": {"description": "PapC, N-terminal domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "PapC_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037225": {"description": "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Nuo51_FMN-bd_sf", "pathway_ids": ["R-DDI-9837999", "R-HSA-611105", "R-MMU-9837999", "R-SPO-9837999", "R-HSA-6799198", "R-MMU-6799198", "R-MMU-611105", "R-HSA-9837999", "R-DDI-6799198"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-6799198:r:Complex I biogenesis"], "type": "Homologous_superfamily"}, "IPR037226": {"description": "CAC2185-like superfamily", "go_ids": [], "go_terms": [], "name": "CAC2185-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037227": {"description": "Endoribonuclease EndoU-like", "go_ids": [], "go_terms": [], "name": "EndoU-like", "pathway_ids": ["R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-191859", "R-HSA-9705671", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR037228": {"description": "PhtA domain superfamily", "go_ids": [], "go_terms": [], "name": "PhtA_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037229": {"description": "Large ribosomal subunit protein bL35 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL35_sf", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383", "R-DME-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Homologous_superfamily"}, "IPR037230": {"description": "Non-structural protein NSP8 superfamily, coronavirus", "go_ids": ["GO:0016740", "GO:0004197", "GO:0008242"], "go_terms": ["GO:0016740:transferase activity:F", "GO:0004197:cysteine-type endopeptidase activity:F", "GO:0008242:omega peptidase activity:F"], "name": "NSP8_sf_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR037231": {"description": "NAP-like superfamily", "go_ids": [], "go_terms": [], "name": "NAP-like_sf", "pathway_ids": ["R-MMU-2299718", "R-RNO-2299718", "R-HSA-450520", "R-HSA-2299718", "R-RNO-450520", "R-HSA-381038", "R-MMU-450520", "R-DME-450520"], "pathways": ["R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA"], "type": "Homologous_superfamily"}, "IPR037232": {"description": "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily", "go_ids": [], "go_terms": [], "name": "NADH_quin_OxRdtase_su_C/D-like", "pathway_ids": ["R-HSA-611105", "R-MMU-9837999", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-DME-9837999", "R-MMU-611105", "R-MMU-9013408", "R-HSA-9837999", "R-HSA-9013408", "R-DDI-6799198", "R-DME-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DDI-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport"], "type": "Homologous_superfamily"}, "IPR037233": {"description": "CcmK-like superfamily", "go_ids": [], "go_terms": [], "name": "CcmK-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037234": {"description": "ImmE5 superfamily", "go_ids": ["GO:0030153"], "go_terms": ["GO:0030153:bacteriocin immunity:P"], "name": "ImmE5_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037235": {"description": "TRCF-like, C-terminal D7 domain", "go_ids": [], "go_terms": [], "name": "TRCF-like_C_D7", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Homologous_superfamily"}, "IPR037236": {"description": "STIV B116-like superfamily", "go_ids": [], "go_terms": [], "name": "STIV_B116-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037237": {"description": "IlvD/EDD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "IlvD/EDD_N", "pathway_ids": ["PWY-7111", "PWY-5101", "PWY-5103", "PWY-5104"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-5103:t:L-isoleucine biosynthesis III", "PWY-5104:t:L-isoleucine biosynthesis IV"], "type": "Homologous_superfamily"}, "IPR037238": {"description": "YbiA-like superfamily", "go_ids": [], "go_terms": [], "name": "YbiA-like_sf", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Homologous_superfamily"}, "IPR037239": {"description": "Oxysterol-binding protein superfamily", "go_ids": [], "go_terms": [], "name": "OSBP_sf", "pathway_ids": ["R-RNO-2132295", "R-MMU-9013407", "R-HSA-2132295", "R-MMU-192105", "R-HSA-192105", "R-HSA-1660661", "R-DDI-192105", "R-HSA-1482801", "R-RNO-192105", "R-SCE-1482801", "R-SPO-192105", "R-XTR-192105", "R-MMU-2132295", "R-DDI-1482801", "R-SPO-1482801", "R-SCE-192105", "R-MMU-1482801", "R-HSA-9013407"], "pathways": ["R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-2132295:r:MHC class II antigen presentation", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-DDI-192105:r:Synthesis of bile acids and bile salts", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-SCE-1482801:r:Acyl chain remodelling of PS", "R-SPO-192105:r:Synthesis of bile acids and bile salts", "R-XTR-192105:r:Synthesis of bile acids and bile salts", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DDI-1482801:r:Acyl chain remodelling of PS", "R-SPO-1482801:r:Acyl chain remodelling of PS", "R-SCE-192105:r:Synthesis of bile acids and bile salts", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Homologous_superfamily"}, "IPR037240": {"description": "ORC1-binding domain", "go_ids": [], "go_terms": [], "name": "ORC1-binding_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037241": {"description": "E2F-DP heterodimerization region", "go_ids": [], "go_terms": [], "name": "E2F-DP_heterodim", "pathway_ids": ["R-MMU-8953750", "R-BTA-69231", "R-HSA-2559580", "R-HSA-69205", "R-DME-69231", "R-HSA-2559585", "R-RNO-2173796", "R-HSA-69231", "R-HSA-8953750", "R-BTA-2173796", "R-HSA-139915", "R-HSA-1912408", "R-MMU-1538133", "R-RNO-68911", "R-HSA-69656", "R-CEL-1538133", "R-HSA-1538133", "R-DME-8953750", "R-HSA-9616222", "R-BTA-8953750", "R-CEL-69231", "R-CEL-68911", "R-MMU-68911", "R-HSA-2173796", "R-BTA-1538133", "R-RNO-1538133", "R-HSA-9661069", "R-HSA-113501", "R-HSA-1362300", "R-MMU-2173796", "R-CEL-2173796", "R-HSA-6804116", "R-DME-1538133", "R-RNO-69231", "R-HSA-1362277", "R-HSA-6804114", "R-HSA-111448", "R-DME-2173796", "R-CEL-8953750", "R-HSA-68911", "R-DME-68911", "R-HSA-69202", "R-MMU-69231"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-69231:r:Cyclin D associated events in G1", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-69205:r:G1/S-Specific Transcription", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-MMU-1538133:r:G0 and Early G1", "R-RNO-68911:r:G2 Phase", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-1538133:r:G0 and Early G1", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-CEL-69231:r:Cyclin D associated events in G1", "R-CEL-68911:r:G2 Phase", "R-MMU-68911:r:G2 Phase", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-1538133:r:G0 and Early G1", "R-RNO-1538133:r:G0 and Early G1", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-DME-1538133:r:G0 and Early G1", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-68911:r:G2 Phase", "R-DME-68911:r:G2 Phase", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Homologous_superfamily"}, "IPR037242": {"description": "Vanadium-binding protein 2 superfamily", "go_ids": [], "go_terms": [], "name": "Vanabin-2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037243": {"description": "Viral leader polypeptide zinc finger", "go_ids": [], "go_terms": [], "name": "Viral_lead_polypep_zc_finger", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037244": {"description": "Thylakoid soluble phosphoprotein TSP9 superfamily", "go_ids": [], "go_terms": [], "name": "TSP9_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037245": {"description": "FIP-RBD, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "FIP-RBD_C_sf", "pathway_ids": ["R-HSA-5620916", "R-HSA-432040", "R-DRE-5620916", "R-MMU-5620916", "R-MMU-432040"], "pathways": ["R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins"], "type": "Homologous_superfamily"}, "IPR037246": {"description": "Extracellular hemoglobin linker subunit, heterodimerisation domain", "go_ids": [], "go_terms": [], "name": "Extrac_hemoglob_link_heterodim", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037247": {"description": "YvfG domain superfamily", "go_ids": [], "go_terms": [], "name": "YvfG_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037249": {"description": "TAFH/NHR1 domain superfamily", "go_ids": ["GO:0006351"], "go_terms": ["GO:0006351:DNA-templated transcription:P"], "name": "TAFH/NHR1_dom_sf", "pathway_ids": ["R-CEL-73779", "R-MMU-75953", "R-DME-674695", "R-DME-76042", "R-MMU-6804756", "R-DME-73779", "R-MMU-674695", "R-CEL-73776", "R-DME-6804756", "R-HSA-167162", "R-HSA-167161", "R-CEL-674695", "R-DME-73776", "R-HSA-9827857", "R-HSA-73776", "R-HSA-6804756", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-HSA-674695", "R-HSA-76042", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-CEL-76042", "R-MMU-76042", "R-HSA-73779"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-9827857:r:Specification of primordial germ cells", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Homologous_superfamily"}, "IPR037250": {"description": "NEAT domain superfamily", "go_ids": [], "go_terms": [], "name": "NEAT_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037251": {"description": "WSSV envelope protein Vp28 superfamily", "go_ids": [], "go_terms": [], "name": "WSSV_Vp28_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037252": {"description": "Mib/herc2 domain superfamily", "go_ids": ["GO:0004842", "GO:0046872"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F", "GO:0046872:metal ion binding:F"], "name": "Mib_Herc2_sf", "pathway_ids": ["R-DME-983168", "R-MMU-5357786", "R-HSA-3108214", "R-HSA-2122948", "R-HSA-69473", "R-HSA-2894862", "R-HSA-9931295", "R-RNO-5357905", "R-HSA-5693565", "R-HSA-983168", "R-HSA-5357786", "R-MMU-5693565", "R-MMU-69473", "R-RNO-9931295", "R-MMU-9931295", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-2979096", "R-HSA-5357905", "R-MMU-5357905", "R-MMU-983168", "R-HSA-2644606", "R-MMU-3108214", "R-HSA-9013507", "R-RNO-5357786", "R-RNO-983168", "R-HSA-2691232", "R-MMU-5693571", "R-MMU-5693607"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Homologous_superfamily"}, "IPR037253": {"description": "TrmB/BL1, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "TrmB_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037255": {"description": "NRDP1, C-terminal", "go_ids": [], "go_terms": [], "name": "NRDP1_C", "pathway_ids": ["PWY-7511", "R-HSA-983168", "R-HSA-1358803", "R-DRE-1358803", "R-MMU-983168", "R-MMU-1358803", "R-DRE-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DRE-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Homologous_superfamily"}, "IPR037256": {"description": "ASC domain superfamily", "go_ids": [], "go_terms": [], "name": "ASC_dom_sf", "pathway_ids": ["R-HSA-9619483", "R-MMU-380972", "R-MMU-1632852", "R-MMU-6804756", "R-RNO-163680", "R-HSA-5628897", "R-BTA-380972", "R-RNO-1632852", "R-BTA-6804756", "R-SPO-200425", "R-RNO-200425", "R-MMU-5628897", "R-SPO-163680", "R-RNO-6804756", "R-HSA-9613354", "R-SCE-200425", "R-SCE-163680", "R-HSA-380972", "R-MMU-163680", "R-HSA-9931269", "R-BTA-9931269", "R-SPO-5628897", "R-MMU-200425", "R-SPO-380972", "R-RNO-5628897", "R-RNO-9931269", "R-HSA-2151209", "R-BTA-1632852", "R-BTA-5628897", "R-SCE-1632852", "R-HSA-6804756", "R-HSA-200425", "R-SCE-380972", "R-HSA-1445148", "R-RNO-380972", "R-MMU-9931269", "R-HSA-1632852", "R-SPO-1632852", "R-HSA-163680"], "pathways": ["R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-1632852:r:Macroautophagy", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9613354:r:Lipophagy", "R-SCE-200425:r:Carnitine shuttle", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-200425:r:Carnitine shuttle", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-BTA-1632852:r:Macroautophagy", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-1632852:r:Macroautophagy", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-200425:r:Carnitine shuttle", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity"], "type": "Homologous_superfamily"}, "IPR037257": {"description": "Type II secretion system protein GspE, N-terminal superfamily", "go_ids": [], "go_terms": [], "name": "T2SS_E_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037258": {"description": "PB2, C-terminal", "go_ids": ["GO:0003723", "GO:0006351"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006351:DNA-templated transcription:P"], "name": "PDB2_C", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-168275", "R-HSA-192814", "R-HSA-192905", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Homologous_superfamily"}, "IPR037259": {"description": "BRK domain superfamily", "go_ids": [], "go_terms": [], "name": "BRK_sf", "pathway_ids": ["PWY-7250", "R-HSA-1989781", "R-DME-9933947", "R-MMU-9933946", "R-HSA-2151201", "R-MMU-1266695", "R-RNO-3214858", "R-MMU-201722", "R-BTA-201722", "R-BTA-9933946", "R-BTA-3247509", "R-HSA-1368108", "R-RNO-8939243", "R-DME-9933939", "R-DME-1266695", "R-HSA-9933387", "R-HSA-9707564", "R-DME-9764725", "R-MMU-3247509", "R-HSA-1266695", "R-DRE-3769402", "R-MMU-9934037", "R-CEL-9933937", "R-HSA-3247509", "R-HSA-9933947", "R-RNO-9934037", "R-HSA-9764725", "R-RNO-9933937", "R-RNO-9933947", "R-MMU-9933939", "R-HSA-8939243", "R-RNO-9764725", "R-HSA-9933937", "R-BTA-8939243", "R-DME-3247509", "R-HSA-400206", "R-MMU-400206", "R-HSA-9818027", "R-CEL-9933947", "R-DME-9933946", "R-DME-8939243", "R-HSA-3769402", "R-RNO-201722", "R-MMU-9933937", "R-HSA-9619665", "R-BTA-9764725", "R-CEL-9934037", "R-DME-9934037", "R-HSA-3214858", "R-BTA-9933937", "R-HSA-9934037", "R-BTA-3214858", "R-BTA-1266695", "R-DME-3214858", "R-HSA-9845323", "R-DME-9933937", "R-BTA-9933939", "R-CEL-9933946", "R-RNO-9933939", "R-HSA-9931509", "R-RNO-9933946", "R-MMU-3769402", "R-RNO-1266695", "R-HSA-381340", "R-BTA-9933947", "R-HSA-9933939", "R-HSA-9707616", "R-MMU-9764725", "R-HSA-9824585", "R-MMU-3214858", "R-MMU-8939243", "R-BTA-9934037", "R-HSA-201722", "R-MMU-9933947", "R-CEL-9764725", "R-CEL-3214858", "R-RNO-3769402", "R-HSA-9933946", "R-RNO-3247509", "R-CEL-9933939", "R-HSA-2426168", "R-MMU-9707564", "R-CEL-8939243"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-MMU-1266695:r:Interleukin-7 signaling", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-BTA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-BTA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-BTA-3247509:r:Chromatin modifying enzymes", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-DME-1266695:r:Interleukin-7 signaling", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-HSA-1266695:r:Interleukin-7 signaling", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-CEL-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-3247509:r:Chromatin modifying enzymes", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-RNO-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-RNO-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-3247509:r:Chromatin modifying enzymes", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-CEL-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-BTA-1266695:r:Interleukin-7 signaling", "R-DME-3214858:r:RMTs methylate histone arginines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-RNO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-RNO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-1266695:r:Interleukin-7 signaling", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-BTA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9707616:r:Heme signaling", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-CEL-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Homologous_superfamily"}, "IPR037261": {"description": "YonK superfamily", "go_ids": [], "go_terms": [], "name": "YonK_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037262": {"description": "TTHC002-like", "go_ids": [], "go_terms": [], "name": "TTHC002-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037263": {"description": "Phosphoprotein, central domain", "go_ids": ["GO:0003968"], "go_terms": ["GO:0003968:RNA-directed RNA polymerase activity:F"], "name": "Phosphoprotein_central", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037264": {"description": "TFIID subunit TAF5, NTD2 domain superfamily", "go_ids": [], "go_terms": [], "name": "TFIID_NTD2_sf", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-SPO-9907900", "R-SCE-75953", "R-DME-76042", "R-SPO-6807505", "R-MMU-6804756", "R-CEL-9907900", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-SCE-6807505", "R-DME-9907900", "R-HSA-73776", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-DME-75953", "R-MMU-73779", "R-CEL-73776", "R-HSA-167172", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-CEL-6807505", "R-DME-674695", "R-MMU-674695", "R-MMU-6807505", "R-DME-6804756", "R-SCE-76042", "R-CEL-674695", "R-SCE-9907900", "R-DME-6807505", "R-HSA-167161", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-3214847", "R-HSA-674695", "R-HSA-76042", "R-SPO-73776", "R-CEL-76042", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-9907900:r:Proteasome assembly", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-9907900:r:Proteasome assembly", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-9907900:r:Proteasome assembly", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-9907900:r:Proteasome assembly", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Homologous_superfamily"}, "IPR037265": {"description": "Poly(A) polymerase catalytic subunit superfamily", "go_ids": ["GO:1990817", "GO:0006397"], "go_terms": ["GO:1990817:poly(A) RNA polymerase activity:F", "GO:0006397:mRNA processing:P"], "name": "PolyA_pol_cat_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037266": {"description": "Photosystem II PsbL superfamily", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "PSII_PsbL_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037267": {"description": "Photosystem II PsbJ superfamily", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "PSII_PsbJ_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037268": {"description": "Photosystem II PsbT superfamily", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "PSII_PsbT_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037269": {"description": "Photosystem II PsbM superfamily", "go_ids": ["GO:0019684"], "go_terms": ["GO:0019684:photosynthesis, light reaction:P"], "name": "PSII_PsbM_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037270": {"description": "Photosystem II PsbK superfamily", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "PSII_PsbK_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037271": {"description": "Photosystem II PsbI superfamily", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "PSII_PsbI_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037272": {"description": "Sodium:neurotransmitter symporter superfamily", "go_ids": [], "go_terms": [], "name": "SNS_sf", "pathway_ids": ["R-HSA-380615", "R-HSA-71288", "R-MMU-888593", "R-CEL-352230", "R-HSA-442660", "R-CFA-71288", "R-MMU-380615", "R-HSA-5619094", "R-CEL-442660", "R-HSA-5619101", "R-BTA-352230", "R-MMU-352230", "R-HSA-888593", "R-RNO-442660", "R-HSA-352230", "R-RNO-352230", "R-MMU-442660", "R-DME-380615", "R-DME-442660", "R-HSA-5659735", "R-HSA-5660686", "R-HSA-5619089", "R-RNO-380615", "R-DME-352230", "R-BTA-380615", "R-HSA-5619081", "R-MMU-379401", "R-CFA-888593", "R-RNO-379401", "R-BTA-71288", "R-RNO-888593", "R-HSA-5619044", "R-HSA-5619109", "R-BTA-442660", "R-MMU-71288", "R-HSA-379401", "R-RNO-71288", "R-BTA-888593", "R-CFA-352230", "R-HSA-5660724"], "pathways": ["R-HSA-380615:r:Serotonin clearance from the synaptic cleft", "R-HSA-71288:r:Creatine metabolism", "R-MMU-888593:r:Reuptake of GABA", "R-CEL-352230:r:Amino acid transport across the plasma membrane", "R-HSA-442660:r:SLC-mediated transport of neurotransmitters", "R-CFA-71288:r:Creatine metabolism", "R-MMU-380615:r:Serotonin clearance from the synaptic cleft", "R-HSA-5619094:r:Variant SLC6A14 may confer susceptibility towards obesity", "R-CEL-442660:r:SLC-mediated transport of neurotransmitters", "R-HSA-5619101:r:Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)", "R-BTA-352230:r:Amino acid transport across the plasma membrane", "R-MMU-352230:r:Amino acid transport across the plasma membrane", "R-HSA-888593:r:Reuptake of GABA", "R-RNO-442660:r:SLC-mediated transport of neurotransmitters", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-MMU-442660:r:SLC-mediated transport of neurotransmitters", "R-DME-380615:r:Serotonin clearance from the synaptic cleft", "R-DME-442660:r:SLC-mediated transport of neurotransmitters", "R-HSA-5659735:r:Defective SLC6A19 causes Hartnup disorder (HND)", "R-HSA-5660686:r:Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)", "R-HSA-5619089:r:Defective SLC6A5 causes hyperekplexia 3 (HKPX3)", "R-RNO-380615:r:Serotonin clearance from the synaptic cleft", "R-DME-352230:r:Amino acid transport across the plasma membrane", "R-BTA-380615:r:Serotonin clearance from the synaptic cleft", "R-HSA-5619081:r:Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)", "R-MMU-379401:r:Dopamine clearance from the synaptic cleft", "R-CFA-888593:r:Reuptake of GABA", "R-RNO-379401:r:Dopamine clearance from the synaptic cleft", "R-BTA-71288:r:Creatine metabolism", "R-RNO-888593:r:Reuptake of GABA", "R-HSA-5619044:r:Defective SLC6A19 causes Hartnup disorder (HND)", "R-HSA-5619109:r:Defective SLC6A2 causes orthostatic intolerance (OI)", "R-BTA-442660:r:SLC-mediated transport of neurotransmitters", "R-MMU-71288:r:Creatine metabolism", "R-HSA-379401:r:Dopamine clearance from the synaptic cleft", "R-RNO-71288:r:Creatine metabolism", "R-BTA-888593:r:Reuptake of GABA", "R-CFA-352230:r:Amino acid transport across the plasma membrane", "R-HSA-5660724:r:Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)"], "type": "Homologous_superfamily"}, "IPR037274": {"description": "Zinc finger, CHY-type superfamily", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "Znf_CHY_sf", "pathway_ids": ["R-HSA-110320", "R-MMU-110320", "R-HSA-983168", "R-HSA-9954709", "R-MMU-983168", "R-MMU-9954709"], "pathways": ["R-HSA-110320:r:Translesion Synthesis by POLH", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Homologous_superfamily"}, "IPR037275": {"description": "Zinc finger, CTCHY-type superfamily", "go_ids": [], "go_terms": [], "name": "Znf_CTCHY_sf", "pathway_ids": ["PWY-7511", "R-HSA-110320", "R-MMU-110320", "R-HSA-983168", "R-HSA-9954709", "R-MMU-983168", "R-MMU-9954709"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Homologous_superfamily"}, "IPR037277": {"description": "Granulin superfamily", "go_ids": [], "go_terms": [], "name": "Granulin_sf", "pathway_ids": ["R-MMU-6798695", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR037278": {"description": "ARFGAP/RecO-like, zinc finger superfamily", "go_ids": [], "go_terms": [], "name": "ARFGAP/RecO_Zfn_sf", "pathway_ids": ["R-SPO-6807878", "R-HSA-9013409", "R-MMU-8856828", "R-HSA-8849469", "R-HSA-8856828", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-6811434", "R-MMU-9013420", "R-RNO-9013424", "R-DME-3928664", "R-RNO-9013408", "R-RNO-9013404", "R-RNO-9013406", "R-HSA-9013408", "R-DDI-193648", "R-MMU-6811434", "R-DME-9013149", "R-MMU-5620916", "R-SCE-6811434", "R-HSA-3928664", "R-RNO-5620916", "R-CEL-6807878", "R-HSA-373752", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013406", "R-SPO-6811434", "R-RNO-9013420", "R-BTA-6811434", "R-MMU-8980692", "R-HSA-1251985", "R-MMU-9013148", "R-DME-9013424", "R-MMU-6807878", "R-DDI-9013149", "R-HSA-9013423", "R-BTA-6807878", "R-HSA-5620916", "R-DME-5620916", "R-HSA-9013148", "R-DME-9013406", "R-HSA-9619229", "R-RNO-8856828", "R-DME-9013423", "R-MMU-3928664", "R-HSA-381038", "R-HSA-9013420", "R-SCE-6807878", "R-RNO-6811434", "R-RNO-8856825", "R-MMU-8849469", "R-RNO-6807878", "R-HSA-6807878", "R-MMU-9013424", "R-RNO-3928664", "R-RNO-9013423", "R-BTA-9013408", "R-HSA-8856825", "R-HSA-9013406", "R-MMU-9013149", "R-CEL-6811434", "R-DME-9013420"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DME-3928664:r:Ephrin signaling", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-9013420:r:RHOU GTPase cycle", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-9013420:r:RHOU GTPase cycle", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-3928664:r:Ephrin signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Homologous_superfamily"}, "IPR037279": {"description": "Photosystem I PsaM, reaction centre superfamily", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "PSI_PsaM_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037282": {"description": "F-actin-capping protein subunit alpha/beta", "go_ids": [], "go_terms": [], "name": "CapZ_alpha/beta", "pathway_ids": ["R-HSA-9013405", "R-HSA-2132295", "R-HSA-879415", "R-GGA-879415", "R-BTA-879415", "R-HSA-983231", "R-HSA-6807878", "R-MMU-879415", "R-HSA-8950505", "R-HSA-3371497", "R-SSC-879415", "R-RNO-879415", "R-HSA-9662360", "R-HSA-9035034", "R-HSA-6811436"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-GGA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-BTA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR037284": {"description": "SUF system FeS cluster assembly, SufBD superfamily", "go_ids": [], "go_terms": [], "name": "SUF_FeS_clus_asmbl_SufBD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037285": {"description": "TM0693-like superfamily", "go_ids": [], "go_terms": [], "name": "TM0693-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037289": {"description": "Elongator complex protein 2", "go_ids": ["GO:0002098", "GO:0033588"], "go_terms": ["GO:0002098:tRNA wobble uridine modification:P", "GO:0033588:elongator holoenzyme complex:C"], "name": "Elp2", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR037291": {"description": "Domain of unknown function DUF4139", "go_ids": [], "go_terms": [], "name": "DUF4139", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR037292": {"description": "Protein D-63 superfamily", "go_ids": [], "go_terms": [], "name": "D-63_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037293": {"description": "Galactose oxidase, central domain superfamily", "go_ids": [], "go_terms": [], "name": "Gal_Oxidase_central_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037294": {"description": "ABC transporter, BtuC-like", "go_ids": [], "go_terms": [], "name": "ABC_BtuC-like", "pathway_ids": ["R-HSA-9638334", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Homologous_superfamily"}, "IPR037295": {"description": "Alpha-lytic protease prodomain", "go_ids": [], "go_terms": [], "name": "Alpha-lytic_protease_prodomain", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037296": {"description": "Staphostatin A/B", "go_ids": ["GO:0004869", "GO:0005737"], "go_terms": ["GO:0004869:cysteine-type endopeptidase inhibitor activity:F", "GO:0005737:cytoplasm:C"], "name": "Staphostatin_A/B", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037321": {"description": "KIN17-like protein", "go_ids": [], "go_terms": [], "name": "KIN17-like", "pathway_ids": ["R-HSA-8876725", "R-MMU-8876725"], "pathways": ["R-HSA-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation"], "type": "Family"}, "IPR037351": {"description": "COMM domain-containing protein 1", "go_ids": ["GO:0055070"], "go_terms": ["GO:0055070:copper ion homeostasis:P"], "name": "Murr1", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation"], "type": "Family"}, "IPR037353": {"description": "Histone methyltransferase complex subunit ASH2", "go_ids": ["GO:0048188"], "go_terms": ["GO:0048188:Set1C/COMPASS complex:C"], "name": "ASH2", "pathway_ids": ["R-SCE-9772755", "R-MMU-8936459", "R-HSA-5617472", "R-MMU-3214841", "R-DME-9772755", "R-HSA-3769402", "R-HSA-9772755", "R-CEL-8936459", "R-MMU-9818564", "R-HSA-8936459", "R-HSA-9944997", "R-MMU-201722", "R-CEL-3214841", "R-DME-201722", "R-HSA-9841922", "R-HSA-201722", "R-HSA-9909649", "R-SPO-9772755", "R-DME-8936459", "R-HSA-3214841", "R-HSA-9818564", "R-CEL-9772755", "R-MMU-9772755", "R-DME-9909649"], "pathways": ["R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription"], "type": "Family"}, "IPR037354": {"description": "COMM domain-containing protein 2", "go_ids": [], "go_terms": [], "name": "Commd2", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation"], "type": "Family"}, "IPR037355": {"description": "COMM domain-containing protein 3", "go_ids": ["GO:0006814"], "go_terms": ["GO:0006814:sodium ion transport:P"], "name": "COMMD3", "pathway_ids": ["R-MMU-8951664", "R-DDI-6798695", "R-MMU-6798695", "R-HSA-6798695", "R-RNO-8951664", "R-RNO-6798695", "R-DDI-8951664", "R-HSA-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-8951664:r:Neddylation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation"], "type": "Family"}, "IPR037357": {"description": "COMM domain-containing protein 5", "go_ids": [], "go_terms": [], "name": "COMMD5", "pathway_ids": ["R-MMU-8951664", "R-BTA-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation"], "type": "Family"}, "IPR037359": {"description": "Heparan sulfate sulfotransferase", "go_ids": ["GO:0008146"], "go_terms": ["GO:0008146:sulfotransferase activity:F"], "name": "NST/OST", "pathway_ids": ["R-MMU-2022928", "R-HSA-2022928", "R-CEL-2022928", "R-DME-2022928", "R-RNO-2022928"], "pathways": ["R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-DME-2022928:r:HS-GAG biosynthesis", "R-RNO-2022928:r:HS-GAG biosynthesis"], "type": "Family"}, "IPR037360": {"description": "COMM domain-containing protein 9", "go_ids": [], "go_terms": [], "name": "COMMD9", "pathway_ids": ["R-MMU-8951664", "R-MMU-6798695", "R-HSA-8951664", "R-HSA-6798695"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR037361": {"description": "COMM domain-containing protein 10", "go_ids": [], "go_terms": [], "name": "COMMD10", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-DDI-8951664", "R-DME-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation"], "type": "Family"}, "IPR037362": {"description": "CAS family", "go_ids": [], "go_terms": [], "name": "CAS_fam", "pathway_ids": ["R-MMU-372708", "R-RNO-186763", 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"R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-2132295:r:MHC class II antigen presentation", "R-XTR-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-5694530:r:Cargo concentration in the ER", "R-MMU-5694530:r:Cargo concentration in the ER", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-XTR-5694530:r:Cargo concentration in the ER", "R-SPO-5694530:r:Cargo concentration in the ER", "R-DRE-5694530:r:Cargo concentration in the ER", "R-DRE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-2132295:r:MHC class II antigen presentation", "R-SCE-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation"], "type": "Family"}, "IPR037365": {"description": "Slowmo/Ups family", "go_ids": ["GO:0005758"], "go_terms": ["GO:0005758:mitochondrial intermembrane space:C"], "name": "Slowmo/Ups", "pathway_ids": ["R-DME-6803204", "R-MMU-6803204", "R-HSA-6803204", "R-SPO-6803204", "R-DDI-6803204", "R-HSA-9837999", "R-SCE-6803204", "R-BTA-6803204"], "pathways": ["R-DME-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-SPO-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C 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"R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-72649:r:Translation initiation complex formation", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR037448": {"description": "Zwei Ig domain protein zig-8", "go_ids": [], "go_terms": [], "name": "Zig-8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037455": {"description": "Aerobactin siderophore biosynthesis, IucA/IucC-like", "go_ids": ["GO:0019290"], "go_terms": ["GO:0019290:siderophore biosynthetic process:P"], "name": "LucA/IucC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037459": {"description": "Rhamnogalacturonan acetylesterase RhgT-like", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "RhgT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037460": {"description": "Streptomyces scabies esterase-like", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "SEST-like", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6857", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6857:t:retinol biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Family"}, "IPR037465": {"description": "YlxR", "go_ids": [], "go_terms": [], "name": "YlxR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037468": {"description": "ARGOS/ARL/OSR1", "go_ids": ["GO:0046622"], "go_terms": ["GO:0046622:positive regulation of organ growth:P"], "name": "ARGOS/ARL/OSR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037469": {"description": "Putative actin-fragmin kinase", "go_ids": [], "go_terms": [], "name": "Put_AFK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037470": {"description": "Protein IVY1", "go_ids": ["GO:0042144", "GO:0000329", "GO:0005543"], "go_terms": ["GO:0042144:vacuole fusion, non-autophagic:P", "GO:0000329:fungal-type vacuole membrane:C", "GO:0005543:phospholipid binding:F"], "name": "IVY1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037471": {"description": "Protein TIC56", "go_ids": [], "go_terms": [], "name": "TIC56", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037472": {"description": "Methyl-CpG-binding domain-containing protein 8", "go_ids": [], "go_terms": [], "name": "MBD8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037473": {"description": "Rubber oxygenase Lcp-like", "go_ids": [], "go_terms": [], "name": "Lcp-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037474": {"description": "Sca1 complex scaffold protein ScaA", "go_ids": [], "go_terms": [], "name": "ScaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037475": {"description": "Kinetochore protein Sos7", "go_ids": ["GO:0000776", "GO:0035591"], "go_terms": ["GO:0000776:kinetochore:C", "GO:0035591:signaling adaptor activity:F"], "name": "Sos7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037476": {"description": "PCH1", "go_ids": ["GO:0010099"], "go_terms": ["GO:0010099:regulation of photomorphogenesis:P"], "name": "PCH1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037477": {"description": "Protein disulfide-isomerase SCO2", "go_ids": [], "go_terms": [], "name": "SCO2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037478": {"description": "YwkD-like domain", "go_ids": [], "go_terms": [], "name": "YwkD-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR037479": {"description": "Tautomerase, MSAD family", "go_ids": [], "go_terms": [], "name": "Tauto_MSAD", "pathway_ids": ["PWY-6550", "PWY-5642"], "pathways": ["PWY-6550:t:carbazole degradation", "PWY-5642:t:2,4-dinitrotoluene degradation"], "type": "Family"}, "IPR037485": {"description": "Peroxisome biogenesis protein 22", "go_ids": ["GO:0007031"], "go_terms": ["GO:0007031:peroxisome organization:P"], "name": "PEX22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037488": {"description": "Uncharacterized protein At2g33490-like", "go_ids": [], "go_terms": [], "name": "At2g33490-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037489": {"description": "DNA repair RAD52-like protein", "go_ids": ["GO:0003677", "GO:0000724"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0000724:double-strand break repair via homologous recombination:P"], "name": "RAD52-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037490": {"description": "WPP domain-associated protein", "go_ids": [], "go_terms": [], "name": "WAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037491": {"description": "Low-temperature-induced 78kDa/65kDa", "go_ids": ["GO:0009737"], "go_terms": ["GO:0009737:response to abscisic acid:P"], "name": "LTI78/LTI65", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037493": {"description": "Exodeoxyribonuclease III-like", "go_ids": ["GO:0008311", "GO:0006281"], "go_terms": ["GO:0008311:double-stranded DNA 3'-5' DNA exonuclease activity:F", "GO:0006281:DNA repair:P"], "name": "ExoIII-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037494": {"description": "Rubisco accumulation factor 1", "go_ids": [], "go_terms": [], "name": "RAF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037495": {"description": "CLAVATA3/ESR (CLE)-related protein 41/42/44", "go_ids": ["GO:0033612", "GO:0010089", "GO:0010087"], "go_terms": ["GO:0033612:receptor serine/threonine kinase binding:F", "GO:0010089:xylem development:P", "GO:0010087:phloem or xylem histogenesis:P"], "name": "CLE41/42/44", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037496": {"description": "BEN domain-containing protein 6-like", "go_ids": ["GO:0045666", "GO:0003714", "GO:0045746"], "go_terms": ["GO:0045666:positive regulation of neuron differentiation:P", "GO:0003714:transcription corepressor activity:F", "GO:0045746:negative regulation of Notch signaling pathway:P"], "name": "BEND6-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037497": {"description": "Protein PROTON GRADIENT REGULATION 5", "go_ids": ["GO:0009773", "GO:0009644"], "go_terms": ["GO:0009773:photosynthetic electron transport in photosystem I:P", "GO:0009644:response to high light intensity:P"], "name": "PGR5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037500": {"description": "Protein MULTIPOLAR SPINDLE 1", "go_ids": ["GO:0000212", "GO:0042138"], "go_terms": ["GO:0000212:meiotic spindle organization:P", "GO:0042138:meiotic DNA double-strand break formation:P"], "name": "Msp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037501": {"description": "Protein TPLATE", "go_ids": ["GO:0006897"], "go_terms": ["GO:0006897:endocytosis:P"], "name": "TPLATE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037502": {"description": "CCG-binding protein 1", "go_ids": ["GO:0010183", "GO:0036033"], "go_terms": ["GO:0010183:pollen tube guidance:P", "GO:0036033:mediator complex binding:F"], "name": "CBP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037504": {"description": "[PSI+] induction protein 2", "go_ids": [], "go_terms": [], "name": "PSI_induc_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037505": {"description": "pH-response regulator protein palC", "go_ids": ["GO:0071467"], "go_terms": ["GO:0071467:cellular response to pH:P"], "name": "pH-resp_palC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037507": {"description": "Large ribosomal subunit protein mL59", "go_ids": ["GO:0005762", "GO:0003735"], "go_terms": ["GO:0005762:mitochondrial large ribosomal subunit:C", "GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_mL59", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037508": {"description": "Meiotically up-regulated protein Msb1/Mug8", "go_ids": [], "go_terms": [], "name": "Msb1/Mug8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037512": {"description": "Phosphoglycolate phosphatase, prokaryotic", "go_ids": ["GO:0008967", "GO:0005975"], "go_terms": ["GO:0008967:phosphoglycolate phosphatase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "PGPase_prok", "pathway_ids": ["PWY-8362", "PWY-8363", "PWY-181"], "pathways": ["PWY-8362:t:photorespiration II", "PWY-8363:t:photorespiration III", "PWY-181:t:photorespiration I"], "type": "Family"}, "IPR037519": {"description": "LITAF domain containing protein", "go_ids": [], "go_terms": [], "name": "LITAF_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037520": {"description": "Folliculin/SMCR8, longin domain", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "Folliculin/SMCR8_longin", "pathway_ids": ["R-RNO-9639288", "R-MMU-9639288", "R-HSA-9639288", "R-XTR-9639288", "R-BTA-9639288"], "pathways": ["R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-BTA-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR037522": {"description": "HD-GYP domain", "go_ids": [], "go_terms": [], "name": "HD_GYP_dom", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I"], "type": "Domain"}, "IPR037525": {"description": "Velvet domain", "go_ids": [], "go_terms": [], "name": "Velvet_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR037539": {"description": "4-hydroxythreonine-4-phosphate dehydrogenase, epsilonproteobacteria", "go_ids": [], "go_terms": [], "name": "PdxA_epsilonprot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037543": {"description": "Prokaryotic ubiquitin-like protein UBact", "go_ids": [], "go_terms": [], "name": "UBact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037546": {"description": "Transcription factor SAC51-like", "go_ids": [], "go_terms": [], "name": "SAC51-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037547": {"description": "Protein SAMBA", "go_ids": ["GO:0010997", "GO:0046621"], "go_terms": ["GO:0010997:anaphase-promoting complex binding:F", "GO:0046621:negative regulation of organ growth:P"], "name": "SAMBA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037548": {"description": "Bouquet formation protein 4", "go_ids": ["GO:0070197", "GO:1990862"], "go_terms": ["GO:0070197:meiotic attachment of telomere to nuclear envelope:P", "GO:1990862:nuclear membrane complex Bqt3-Bqt4:C"], "name": "Bqt4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037549": {"description": "Uncharacterized protein C19orf18", "go_ids": [], "go_terms": [], "name": "C19orf18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037578": {"description": "Von Willebrand factor", "go_ids": [], "go_terms": [], "name": "Von_Willebrand_factor", "pathway_ids": ["R-MMU-354192", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-216083", "R-MMU-5674135", "R-HSA-6802952", "R-HSA-9845620", "R-HSA-9656223", "R-MMU-76009", "R-HSA-140837", "R-HSA-430116", "R-HSA-9672393", "R-HSA-9845619", "R-MMU-430116", "R-HSA-354194", "R-MMU-140837", "R-MMU-354194", "R-HSA-9845622", "R-HSA-9845621", "R-MMU-372708", "R-HSA-114608", "R-HSA-76009", "R-HSA-75892", "R-MMU-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-9846298", "R-HSA-9672391", "R-MMU-216083", "R-HSA-372708", "R-HSA-6802955", "R-HSA-354192"], "pathways": ["R-MMU-354192:r:Integrin signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-354192:r:Integrin signaling"], "type": "Family"}, "IPR037579": {"description": "Fibrinogen/angiopoietin-like", "go_ids": ["GO:0007596"], "go_terms": ["GO:0007596:blood coagulation:P"], "name": "FIB_ANG-like", "pathway_ids": ["R-HSA-1989781", "R-SSC-9762292", "R-BTA-9762292", "R-MMU-5674135", "R-HSA-5674135", "R-RNO-216083", "R-HSA-6802952", "R-RNO-372708", "R-HSA-9656223", "R-BTA-5673001", "R-HSA-977225", "R-HSA-8963889", "R-CFA-210993", "R-RNO-9762292", "R-RNO-140875", "R-MMU-210993", "R-RNO-354194", "R-MMU-8957275", "R-HSA-9841922", "R-RNO-114608", "R-MMU-372708", "R-HSA-114608", "R-RNO-354192", "R-HSA-9649948", "R-HSA-6802946", "R-MMU-381426", "R-RNO-8957275", "R-RNO-8963889", "R-RNO-5674135", "R-HSA-5686938", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-6802955", "R-HSA-381426", "R-HSA-354192", "R-RNO-5686938", "R-HSA-166058", "R-RNO-210993", "R-HSA-216083", "R-HSA-210993", "R-HSA-6802948", "R-HSA-381340", "R-MMU-8963889", "R-HSA-354194", "R-BTA-8963889", "R-MMU-354194", "R-MMU-5686938", "R-HSA-140875", "R-MMU-9762292", "R-SSC-8963889", "R-MMU-140875", "R-HSA-5673001", "R-RNO-381426", "R-MMU-216083", "R-BTA-210993", "R-HSA-1236974", "R-HSA-5603041", "R-HSA-5602498", "R-HSA-8957275", "R-HSA-372708", "R-MMU-6798695", "R-HSA-9762292", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-SSC-9762292:r:Regulation of CDH11 function", "R-BTA-9762292:r:Regulation of CDH11 function", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-CFA-210993:r:Tie2 Signaling", "R-RNO-9762292:r:Regulation of CDH11 function", "R-RNO-140875:r:Common Pathway of Fibrin Clot 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"R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-354192:r:Integrin signaling", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-210993:r:Tie2 Signaling", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-MMU-354194:r:GRB2:SOS provides linkage to 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"R-HSA-2467813", "R-RNO-2500257", "R-MMU-3232142", "R-SPO-159227", "R-SPO-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-HSA-168333", "R-MMU-4085377", "R-HSA-68877", "R-HSA-165054", "R-CEL-3108214", "R-RNO-159236", "R-HSA-4615885", "R-MMU-9648025", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-DME-4551638", "R-HSA-4085377", "R-RNO-159227", "R-CEL-9615933", "R-RNO-4551638", "R-DME-159230", "R-DME-3301854", "R-RNO-170822", "R-RNO-159231", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-180746", "R-CEL-3371453", "R-CEL-159236"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", 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Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Family"}, "IPR037682": {"description": "TonB, C-terminal", "go_ids": ["GO:0055085"], "go_terms": ["GO:0055085:transmembrane transport:P"], "name": "TonB_C", "pathway_ids": ["R-HSA-9638334", "R-HSA-9927020", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9927020:r:Heme assimilation", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR037688": {"description": "Zinc finger B-box domain-containing protein", "go_ids": [], "go_terms": [], "name": "ZBBX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037689": {"description": "BAG family molecular chaperone regulator 2", "go_ids": ["GO:0051087", "GO:0000774"], "go_terms": ["GO:0051087:protein-folding chaperone binding:F", "GO:0000774:adenyl-nucleotide exchange factor activity:F"], "name": "BAG2", "pathway_ids": ["R-HSA-9918487", "R-BTA-3371453", "R-HSA-3371453", "R-MMU-3371453"], "pathways": ["R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Family"}, "IPR037690": {"description": "Protein FAM204A", "go_ids": [], "go_terms": [], "name": "FAM204A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037691": {"description": "28S rRNA/ribosome and sororin micro-cofactor", "go_ids": [], "go_terms": [], "name": "RSMC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037692": {"description": "Centrosomal protein of 70kDa", "go_ids": ["GO:0005813", "GO:0043015", "GO:0070507", "GO:0060271"], "go_terms": ["GO:0005813:centrosome:C", "GO:0043015:gamma-tubulin binding:F", "GO:0070507:regulation of microtubule cytoskeleton organization:P", "GO:0060271:cilium assembly:P"], "name": "CEP70", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-MMU-380270", "R-HSA-380284", "R-HSA-380270", "R-RNO-5620912", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-RNO-380320", "R-RNO-380259", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Family"}, "IPR037693": {"description": "Coiled-coil domain-containing protein 15", "go_ids": [], "go_terms": [], "name": "CCDC15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037694": {"description": "Mitochondrial nucleoid-associated protein 1", "go_ids": [], "go_terms": [], "name": "MTNAP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037695": {"description": "IQ motif and ubiquitin-like domain-containing protein", "go_ids": [], "go_terms": [], "name": "IQUB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037696": {"description": "Coiled-coil domain-containing protein 77", "go_ids": [], "go_terms": [], "name": "CCDC77", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037698": {"description": "Ubiquinol-cytochrome-c reductase complex assembly factor 2", "go_ids": [], "go_terms": [], "name": "UQCC2", "pathway_ids": ["R-HSA-9865881"], "pathways": ["R-HSA-9865881:r:Complex III assembly"], "type": "Family"}, "IPR037699": {"description": "Uncharacterized protein At5g65660-like", "go_ids": [], "go_terms": [], "name": "At5g65660-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037700": {"description": "Nucleoporin NUP88/NUP82", "go_ids": ["GO:0017056", "GO:0000055", "GO:0000056", "GO:0006913"], "go_terms": ["GO:0017056:structural constituent of nuclear pore:F", "GO:0000055:ribosomal large subunit export from nucleus:P", "GO:0000056:ribosomal small subunit export from nucleus:P", "GO:0006913:nucleocytoplasmic transport:P"], "name": "NUP88/NUP82", "pathway_ids": ["R-HSA-180910", "R-DRE-3232142", "R-RNO-3301854", "R-DRE-4551638", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-RNO-191859", "R-HSA-3371453", "R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-DME-3371453", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-DME-159227", "R-HSA-168325", "R-MMU-170822", "R-HSA-9609690", "R-DRE-3371453", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-RNO-4085377", "R-SPO-4570464", "R-DRE-159227", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-SPO-159227", "R-SPO-159231", "R-DRE-159231", "R-DME-159236", "R-DME-159231", "R-HSA-1169408", "R-DRE-191859", "R-MMU-4615885", "R-HSA-159227", "R-DRE-159236", "R-DRE-3108214", "R-MMU-4085377", "R-HSA-168333", "R-HSA-165054", "R-RNO-159236", "R-HSA-4615885", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-DME-4551638", "R-HSA-4085377", "R-RNO-159227", "R-RNO-4551638", "R-DME-159230", "R-DME-3301854", "R-RNO-170822", "R-DRE-3301854", "R-RNO-159231", "R-HSA-180746"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4551638:r:SUMOylation of chromatin 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from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DRE-191859:r:snRNP Assembly", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Family"}, "IPR037701": {"description": "Nucleoporin Pom152", "go_ids": ["GO:0017056"], "go_terms": ["GO:0017056:structural constituent of nuclear pore:F"], "name": "Pom152", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037721": {"description": "Ferlin family", "go_ids": [], "go_terms": [], "name": "Ferlin", "pathway_ids": ["R-HSA-9662360", "R-HSA-9609523", "R-HSA-445355"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-445355:r:Smooth Muscle Contraction"], "type": "Family"}, "IPR037727": {"description": "Microtubule-actin cross-linking factor 1-like", "go_ids": [], "go_terms": [], "name": "MCAF1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037728": {"description": "Uncharacterized protein C21orf140-like", "go_ids": [], "go_terms": [], "name": "C21orf140-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037729": {"description": "Neuropeptide CCHamide 1/2", "go_ids": ["GO:0007218", "GO:0005184"], "go_terms": ["GO:0007218:neuropeptide signaling pathway:P", "GO:0005184:neuropeptide hormone activity:F"], "name": "CCHa1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037730": {"description": "Mitochondrial inner membrane protease subunit 2", "go_ids": ["GO:0008236", "GO:0042720", "GO:0051604", "GO:0070585"], "go_terms": ["GO:0008236:serine-type peptidase activity:F", "GO:0042720:mitochondrial inner membrane peptidase complex:C", "GO:0051604:protein maturation:P", "GO:0070585:protein localization to mitochondrion:P"], "name": "IMP2", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR037731": {"description": "Meiosis-specific protein ASY3-like", "go_ids": ["GO:0051321"], "go_terms": ["GO:0051321:meiotic cell cycle:P"], "name": "ASY3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037734": {"description": "Thylakoid lumenal 17.9kDa protein", "go_ids": [], "go_terms": [], "name": "Thylakoid_lumenal_17.9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037735": {"description": "Cadmium-induced protein AS8-like", "go_ids": [], "go_terms": [], "name": "AS8-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037736": {"description": "Photosystem I assembly factor PSA3", "go_ids": ["GO:0048564"], "go_terms": ["GO:0048564:photosystem I assembly:P"], "name": "PSA3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037737": {"description": "Regulator of phospholipase D Srf1", "go_ids": [], "go_terms": [], "name": "Srf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037738": {"description": "Protein Ecm13-like", "go_ids": [], "go_terms": [], "name": "Ecm13-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037739": {"description": "Uncharacterized protein C6orf141", "go_ids": [], "go_terms": [], "name": "C6orf141", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037746": {"description": "Protein Dok-7", "go_ids": ["GO:0019901", "GO:0061098"], "go_terms": ["GO:0019901:protein kinase binding:F", "GO:0061098:positive regulation of protein tyrosine kinase activity:P"], "name": "Dok-7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037758": {"description": "Coiled-coil domain-containing protein 54", "go_ids": [], "go_terms": [], "name": "CCDC54", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037759": {"description": "Uncharacterized protein At4g29660-like", "go_ids": [], "go_terms": [], "name": "At4g29660-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037760": {"description": "Small lysine-rich protein 1", "go_ids": [], "go_terms": [], "name": "SMKR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037763": {"description": "Transmembrane protein C1orf162", "go_ids": [], "go_terms": [], "name": "C1orf162", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037764": {"description": "Protein CEBPZOS", "go_ids": [], "go_terms": [], "name": "CEBPZOS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037766": {"description": "Protein FAR-RED ELONGATED HYPOCOTYL 1", "go_ids": ["GO:0009639"], "go_terms": ["GO:0009639:response to red or far red light:P"], "name": "FHY1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037769": {"description": "Abr/Bcr", "go_ids": ["GO:0005096", "GO:0043547"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0043547:positive regulation of GTPase activity:P"], "name": "Abr/Bcr", "pathway_ids": ["R-RNO-9013026", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-9013149", "R-HSA-9013106", "R-MMU-9013148", "R-MMU-9013404", "R-BTA-9013148", "R-BTA-9013423", "R-HSA-9013423", "R-RNO-416482", "R-HSA-9013148", "R-RNO-9013404", "R-RNO-9013106", "R-HSA-5655302", "R-RNO-193648", "R-HSA-193648", "R-HSA-416482", "R-RNO-9013148", "R-BTA-416482", "R-RNO-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-BTA-9013404", "R-MMU-9013026", "R-MMU-416482", "R-MMU-193648", "R-HSA-9013026", "R-BTA-8980692", "R-MMU-9013149", "R-BTA-9013106", "R-HSA-1839117"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC 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death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Family"}, "IPR037770": {"description": "Cyclin-dependent kinase 7", "go_ids": ["GO:0070985", "GO:0005675", "GO:0008353"], "go_terms": ["GO:0070985:transcription factor TFIIK complex:C", "GO:0005675:transcription factor TFIIH holo complex:C", "GO:0008353:RNA polymerase II CTD heptapeptide repeat kinase activity:F"], "name": "CDK7", "pathway_ids": ["R-RNO-6781823", "R-CEL-73779", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-RNO-73779", "R-HSA-69202", "R-HSA-427413", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-HSA-69231", "R-HSA-167158", "R-MMU-75955", "R-RNO-73776", "R-MMU-112382", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-HSA-69656", "R-DDI-674695", "R-CEL-75953", "R-SPO-6796648", "R-CEL-69231", "R-CEL-73776", 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"name": "Kindlin/fermitin", "pathway_ids": ["R-DME-9013149", "R-MMU-446353", "R-CEL-9013423", "R-DME-114608", "R-CEL-114608", "R-CEL-446353", "R-CEL-9013149", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-114608", "R-BTA-114608", "R-MMU-114608", "R-HSA-9013149", "R-HSA-446353", "R-DRE-9013149", "R-DRE-446353", "R-DME-446353", "R-MMU-9013149", "R-DME-9013423", "R-DRE-9013423"], "pathways": ["R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DME-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DRE-446353:r:Cell-extracellular matrix interactions", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR037847": {"description": "GRAM domain-containing protein 4", "go_ids": ["GO:0006915"], "go_terms": ["GO:0006915:apoptotic process:P"], "name": "GRAMDC4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037848": {"description": "GEM-like protein", "go_ids": [], "go_terms": [], "name": "GEM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037850": {"description": "Retinoblastoma-binding protein 5/Swd1", "go_ids": ["GO:0048188"], "go_terms": ["GO:0048188:Set1C/COMPASS complex:C"], "name": "RBBP5/Swd1", "pathway_ids": ["R-SCE-9772755", "R-MMU-8936459", "R-DME-9909649", "R-MMU-3214841", "R-HSA-3769402", "R-DME-9772755", "R-HSA-9772755", "R-CEL-8936459", "R-HSA-8936459", "R-HSA-9944997", "R-HSA-8951664", "R-MMU-9818564", "R-MMU-201722", "R-DME-8951664", "R-CEL-3214841", "R-HSA-9841922", "R-DDI-8951664", "R-DME-201722", "R-MMU-8951664", "R-HSA-201722", "R-HSA-9909649", "R-SPO-9772755", "R-HSA-3214841", "R-DME-8936459", "R-HSA-9818564", "R-DDI-9772755", "R-CEL-9772755", "R-SPO-8951664", "R-MMU-9772755", "R-HSA-5617472", "R-CEL-8951664"], "pathways": ["R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet 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lysines", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-DDI-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-SPO-8951664:r:Neddylation", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-CEL-8951664:r:Neddylation"], "type": "Family"}, "IPR037855": {"description": "Vacuolar protein sorting protein 36", "go_ids": ["GO:0000814", "GO:0043130", "GO:0032509"], "go_terms": ["GO:0000814:ESCRT II complex:C", "GO:0043130:ubiquitin binding:F", "GO:0032509:endosome transport via multivesicular body sorting pathway:P"], "name": "Vps36", "pathway_ids": ["R-RNO-917729", "R-HSA-917729", "R-HSA-9610379", "R-DRE-917729", 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"type": "Homologous_superfamily"}, "IPR037878": {"description": "Sperm acrosome membrane-associated protein 1", "go_ids": ["GO:0002080"], "go_terms": ["GO:0002080:acrosomal membrane:C"], "name": "SPACA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037883": {"description": "Knr4/Smi1-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Knr4/Smi1-like_sf", "pathway_ids": ["R-HSA-8955332"], "pathways": ["R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Homologous_superfamily"}, "IPR037891": {"description": "Immunity protein Cdil-like superfamily", "go_ids": [], "go_terms": [], "name": "Cdil-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037895": {"description": "NudC domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "NUDCD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037898": {"description": "NudC family", "go_ids": [], "go_terms": [], "name": 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NUDC in mitotic spindle formation", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR037912": {"description": "Microspherule protein 1", "go_ids": ["GO:0071339", "GO:0031011", "GO:0002151"], "go_terms": ["GO:0071339:MLL1 complex:C", "GO:0031011:Ino80 complex:C", "GO:0002151:G-quadruplex RNA binding:F"], "name": "MCRS1", "pathway_ids": ["R-MMU-3214847", "R-HSA-9772755", "R-HSA-5696394", "R-HSA-3214847", "R-HSA-5689603", "R-MMU-9772755", "R-MMU-5696394", "R-MMU-5689603"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH proteinases"], "type": "Family"}, "IPR037914": {"description": "SpoVT-AbrB domain superfamily", "go_ids": [], "go_terms": [], "name": "SpoVT-AbrB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037919": {"description": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit", "go_ids": ["GO:0016757", "GO:0006493"], "go_terms": ["GO:0016757:glycosyltransferase activity:F", "GO:0006493:protein O-linked glycosylation:P"], "name": "OGT", "pathway_ids": ["PWY-7437", "R-HSA-5213460", "R-MMU-3214847", "R-RNO-5689603", "R-RNO-3214847", "R-HSA-9772755", "R-RNO-9772755", "R-HSA-5675482", "R-MMU-5675482", "R-RNO-5675482", "R-HSA-3214847", "R-HSA-5689603", "R-MMU-9772755", "R-MMU-5689603"], "pathways": ["PWY-7437:t:protein O-[N-acetyl]-glucosylation", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-3214847:r:HATs acetylate histones", "R-RNO-5689603:r:UCH proteinases", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5689603:r:UCH proteinases"], "type": "Family"}, "IPR037922": {"description": "E3 ubiquitin-protein ligase MSL2", "go_ids": ["GO:0061630", "GO:0072487"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0072487:MSL complex:C"], "name": "MSL2", "pathway_ids": ["PWY-7511", "R-MMU-3214847", "R-HSA-3214847", "R-DME-3214847", "R-GGA-3214847"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-GGA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR037923": {"description": "Transcription regulator HTH-like", "go_ids": [], "go_terms": [], "name": "HTH-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037925": {"description": "Flagellar hook-basal body protein, FlgE/F/G-like", "go_ids": [], "go_terms": [], "name": "FlgE/F/G-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR037930": {"description": "Tom40", "go_ids": ["GO:0008320", "GO:0030150", "GO:0005741"], "go_terms": ["GO:0008320:transmembrane protein transporter activity:F", "GO:0030150:protein import into mitochondrial matrix:P", "GO:0005741:mitochondrial outer membrane:C"], "name": "Tom40", "pathway_ids": ["R-HSA-5205685", "R-RNO-5205685", "R-MMU-5205685", "R-HSA-1268020", "R-BTA-5205685"], "pathways": ["R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy"], "type": "Family"}, "IPR037936": {"description": "Netrin receptor UNC5A-D", "go_ids": ["GO:0005042", "GO:0038007", "GO:0016020"], "go_terms": ["GO:0005042:netrin receptor activity:F", "GO:0038007:netrin-activated signaling pathway:P", "GO:0016020:membrane:C"], "name": "UNC5A-D", "pathway_ids": ["R-CEL-373752", "R-HSA-418889", "R-HSA-418886", "R-RNO-373752", "R-HSA-373752", "R-MMU-373752", "R-DME-373752"], "pathways": ["R-CEL-373752:r:Netrin-1 signaling", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-RNO-373752:r:Netrin-1 signaling", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-373752:r:Netrin-1 signaling", "R-DME-373752:r:Netrin-1 signaling"], "type": "Family"}, "IPR037939": {"description": "Death domain-containing protein CRADD", "go_ids": ["GO:0070513", "GO:0002020"], "go_terms": ["GO:0070513:death domain binding:F", "GO:0002020:protease binding:F"], "name": "CRADD", "pathway_ids": ["R-HSA-6803207", "R-MMU-6803207"], "pathways": ["R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases"], "type": "Family"}, "IPR037941": {"description": "Selenoprotein P", "go_ids": ["GO:0008430"], "go_terms": ["GO:0008430:selenium binding:F"], "name": "SeP", "pathway_ids": ["R-HSA-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation"], "type": "Family"}, "IPR037944": {"description": "Peroxiredoxin-5-like", "go_ids": ["GO:0034599", "GO:0008379"], "go_terms": ["GO:0034599:cellular response to oxidative stress:P", "GO:0008379:thioredoxin peroxidase activity:F"], "name": "PRX5-like", "pathway_ids": ["R-BTA-3299685", "R-MMU-5628897", "R-RNO-5628897", "R-MMU-3299685", "R-HSA-5628897", "R-RNO-3299685", "R-BTA-5628897", "R-HSA-3299685"], "pathways": ["R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species"], "type": "Family"}, "IPR037948": {"description": "Chromo domain-containing protein cec-4", "go_ids": ["GO:0097240"], "go_terms": ["GO:0097240:chromosome attachment to the nuclear envelope:P"], "name": "Cec-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037952": {"description": "Sensor histidine kinase TorS, sensor domain", "go_ids": [], "go_terms": [], "name": "Sensor_TorS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR037962": {"description": "Neuralized", "go_ids": [], "go_terms": [], "name": "Neuralized", "pathway_ids": ["R-MMU-8951664", "R-HSA-2979096", "R-HSA-2122948", "R-HSA-8951664", "R-HSA-2894862", "R-HSA-2644606", "R-HSA-9013507", "R-HSA-2691232"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-8951664:r:Neddylation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants"], "type": "Family"}, "IPR037992": {"description": "TRAPP complex, Trs33 subunit", "go_ids": ["GO:0043087", "GO:0048193"], "go_terms": ["GO:0043087:regulation of GTPase activity:P", "GO:0048193:Golgi vesicle transport:P"], "name": "TRAPPC6/Trs33", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-MMU-8876198", "R-DRE-204005", "R-SCE-204005", "R-SPO-204005", "R-BTA-204005", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198", "R-DRE-8876198"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-204005:r:COPII-mediated vesicle transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR037994": {"description": "Nucleoside diphosphate kinase 6", "go_ids": ["GO:0004550"], "go_terms": ["GO:0004550:nucleoside diphosphate kinase activity:F"], "name": "NDPk6", "pathway_ids": ["PWY-7198", "PWY-7221", "PWY-7205", "PWY-6545", "PWY-7226", "PWY-7176", "PWY-7222", "PWY-7184", "PWY-7224", "PWY-7187", "PWY-8289", "PWY-7220", "PWY-7197", "PWY-7227", "PWY-7210"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-7221:t:guanosine ribonucleotides de novo biosynthesis", "PWY-7205:t:CMP phosphorylation", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7176:t:UTP and CTP de novo biosynthesis", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7224:t:purine deoxyribonucleosides salvage", "PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II", "PWY-8289:t:dZTP biosynthesis", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7197:t:pyrimidine deoxyribonucleotide phosphorylation", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Family"}, "IPR037997": {"description": "CTP-dependent diacylglycerol kinase 1-like", "go_ids": ["GO:0004143"], "go_terms": ["GO:0004143:ATP-dependent diacylglycerol kinase activity:F"], "name": "Dgk1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR037998": {"description": "Maternal protein exuperantia", "go_ids": ["GO:0045450", "GO:0003723", "GO:0042803"], "go_terms": ["GO:0045450:bicoid mRNA localization:P", "GO:0003723:RNA binding:F", "GO:0042803:protein homodimerization activity:F"], "name": "Exu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038000": {"description": "E1A-binding protein p400", "go_ids": ["GO:0035267"], "go_terms": ["GO:0035267:NuA4 histone acetyltransferase complex:C"], "name": "EP400", "pathway_ids": ["R-HSA-2559584", "R-HSA-3214847", "R-MMU-2559584", "R-HSA-2559586", "R-MMU-2559586"], "pathways": ["R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Family"}, "IPR038003": {"description": "Alpha-2-macroglobulin receptor-associated protein", "go_ids": ["GO:0050750", "GO:0048019"], "go_terms": ["GO:0050750:low-density lipoprotein particle receptor binding:F", "GO:0048019:receptor antagonist activity:F"], "name": "A2-macroglobuin_RAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038007": {"description": "RBP-Jkappa, IPT domain", "go_ids": ["GO:0003677", "GO:0006355"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RBP-Jkappa_IPT", "pathway_ids": ["R-HSA-9013508", "R-DME-350054", "R-HSA-8941856", "R-HSA-210744", "R-MMU-2122947", "R-HSA-2894862", "R-HSA-9824272", "R-BTA-8941856", "R-HSA-350054", "R-BTA-350054", "R-HSA-1912408", "R-HSA-9013695", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-2122947"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-DME-350054:r:Notch-HLH transcription pathway", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9824272:r:Somitogenesis", "R-BTA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Domain"}, "IPR038013": {"description": "ALG11 mannosyltransferase", "go_ids": ["GO:0004377"], "go_terms": ["GO:0004377:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity:F"], "name": "ALG11", "pathway_ids": ["R-HSA-4551295", "R-HSA-446193"], "pathways": ["R-HSA-4551295:r:Defective ALG11 causes CDG-1p", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Family"}, "IPR038014": {"description": "Ino80 subunit 1", "go_ids": ["GO:0031011"], "go_terms": ["GO:0031011:Ino80 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"PWY-2229:t:superpathway of pterocarpan biosynthesis (via formononetin)", "PWY-5793:t:maysin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-2467:t:(+)-pisatin biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6602:t:naringenin C-glucosylation", "PWY-6679:t:jadomycin biosynthesis", "PWY-7757:t:bisphenol A degradation", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-721:t:3-methylquinoline degradation", "PWY-5644:t:4-nitrotoluene degradation II", "PWY-5408:t:9-lipoxygenase and 9-hydroperoxide lyase pathway", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7189:t:pinocembrin C-glucosylation", "PWY-5410:t:traumatin and (Z)-3-hexen-1-yl acetate biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5061:t:6,7,4'-trihydroxyisoflavone biosynthesis", "PWY-6721:t:sangivamycin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-5409:t:divinyl ether biosynthesis II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7428:t:2-chloroacrylate degradation II", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)"], "type": "Homologous_superfamily"}, "IPR038023": {"description": "VASP tetramerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "VASP_sf", "pathway_ids": ["R-MMU-446353", "R-MMU-376176", "R-HSA-446353", "R-HSA-202433", "R-DDI-5658442", "R-HSA-376176", "R-HSA-5663220", "R-DDI-446353", "R-DME-446353", "R-RNO-5663220", "R-MMU-5663220"], "pathways": ["R-MMU-446353:r:Cell-extracellular matrix interactions", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-HSA-202433:r:Generation of second messenger molecules", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DDI-446353:r:Cell-extracellular matrix interactions", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Homologous_superfamily"}, "IPR038024": {"description": "SPy1572-like superfamily", "go_ids": [], "go_terms": [], "name": "SPy1572-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038025": {"description": "Antitoxin CbeA superfamily", "go_ids": [], "go_terms": [], "name": "CbeA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038026": {"description": "MtlR-like superfamily", "go_ids": [], "go_terms": [], "name": "MtlR-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038027": {"description": "YorP domain superfamily", "go_ids": [], "go_terms": [], "name": "YorP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038028": {"description": "Nucleosome-remodeling factor subunit BPTF", "go_ids": ["GO:0016589", "GO:0006357"], "go_terms": ["GO:0016589:NURF complex:C", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "BPTF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038029": {"description": "GbiG N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "GbiG_N_sf", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Homologous_superfamily"}, "IPR038030": {"description": "NSP1 globular domain superfamily, betacoronavirus", "go_ids": [], "go_terms": [], "name": "NSP1_glob_sf_bCoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR038031": {"description": "Tp47 lipoprotein, middle and C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tp47_mid_C_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038032": {"description": "Capsid assembly scaffolding protein Gp7", "go_ids": [], "go_terms": [], "name": "Gp7", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038042": {"description": "Gp37-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Gp37-like", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038050": {"description": "Neuronal acetylcholine receptor", "go_ids": [], "go_terms": [], "name": "Neuro_actylchol_rec", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-BTA-629597", "R-HSA-9667769", "R-DME-629594", "R-CEL-6798695", "R-HSA-977443", "R-GGA-977443", "R-BTA-112314", "R-DRE-629597", "R-BTA-629587", "R-CEL-112314", "R-HSA-629594", "R-RNO-112314", "R-RNO-629597", "R-MMU-112314", "R-MMU-629597", "R-DME-629587", "R-GGA-629587", "R-RNO-629594", "R-DRE-629594", "R-DME-6798695", "R-DME-977443", "R-RNO-629587", "R-GGA-629594", "R-DME-112314", "R-HSA-629587", "R-CEL-977443", "R-HSA-1236394", "R-CEL-629597", "R-GGA-629597", "R-BTA-977443", "R-CEL-629594", "R-DME-629597", "R-MMU-629587", "R-DRE-112314", "R-MMU-6798695", "R-MMU-977443", "R-BTA-629594", "R-HSA-112314", "R-CEL-629587", "R-MMU-629594", "R-HSA-629597", "R-RNO-977443"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-DME-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977443:r:GABA receptor activation", "R-GGA-977443:r:GABA receptor activation", "R-BTA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-DRE-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-CEL-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-RNO-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-RNO-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-MMU-112314:r:Neurotransmitter receptors and 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"R-CEL-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-GGA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-BTA-977443:r:GABA receptor activation", "R-CEL-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-DME-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-MMU-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-DRE-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-977443:r:GABA receptor activation", "R-BTA-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-CEL-629587:r:Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "R-MMU-629594:r:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-629597:r:Highly calcium permeable nicotinic acetylcholine receptors", "R-RNO-977443:r:GABA receptor activation"], "type": "Homologous_superfamily"}, "IPR038051": {"description": "XRCC4-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "XRCC4-like_N_sf", "pathway_ids": ["R-HSA-5693571", "R-DRE-5693571", "R-HSA-3108214", "R-DDI-5693571", "R-DDI-3108214", "R-MMU-3108214", "R-RNO-5693571", "R-MMU-5693571", "R-HSA-164843"], "pathways": ["R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-164843:r:2-LTR circle formation"], "type": "Homologous_superfamily"}, "IPR038052": {"description": "Chaperonin-like RbcX superfamily", "go_ids": [], "go_terms": [], "name": "Chaperonin_RbcX_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038054": {"description": "L,D-transpeptidase central domain-like superfamily", "go_ids": [], "go_terms": [], "name": "LD_TPept-like_central_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038055": {"description": "Flaviviral glycoprotein E, dimerisation domain", "go_ids": [], "go_terms": [], "name": "Glycoprot_E_dimer_dom", "pathway_ids": ["R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Homologous_superfamily"}, "IPR038056": {"description": "YjbR-like superfamily", "go_ids": [], "go_terms": [], "name": "YjbR-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038057": {"description": "EV matrix domain superfamily", "go_ids": [], "go_terms": [], "name": "EV_matrix_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038058": {"description": "PhnH-like superfamily", "go_ids": [], "go_terms": [], "name": "PhnH-like_sp", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038060": {"description": "KICSTOR complex protein C12orf66-like, central domain superfamily", "go_ids": [], "go_terms": [], "name": "C12orf66-like_central_sf", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288", "R-DRE-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DRE-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR038062": {"description": "ScdA-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ScdA-like_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038063": {"description": "L,D-transpeptidase catalytic domain-like", "go_ids": [], "go_terms": [], "name": "Transpep_catalytic_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038064": {"description": "Influenza A virus NS1, effector domain-like superfamily", "go_ids": [], "go_terms": [], "name": "NS1A_effect_dom-like_sf", "pathway_ids": ["R-HSA-5213460", "R-HSA-168888", "R-HSA-168276", "R-HSA-9833482", "R-HSA-168315", "R-HSA-1169408", "R-HSA-9686347", "R-HSA-169131", "R-HSA-9953170", "R-HSA-192823"], "pathways": ["R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-168888:r:Inhibition of IFN-beta", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-168315:r:Inhibition of Host mRNA Processing and RNA Silencing", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-169131:r:Inhibition of PKR", "R-HSA-9953170:r:GBP-mediated host defense", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Homologous_superfamily"}, "IPR038065": {"description": "Tetrabrachion, parallel right-handed coiled coil domain", "go_ids": [], "go_terms": [], "name": "Tetrabrachion_parallel_CC", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038066": {"description": "Spc24, Fungi, globular domain superfamily", "go_ids": [], "go_terms": [], "name": "Spc24_Fungi_globular_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038068": {"description": "YcgL-like superfamily", "go_ids": [], "go_terms": [], "name": "YcgL-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038069": {"description": "Pelota/DOM34, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Pelota/DOM34_N", "pathway_ids": ["R-DRE-9954714", "R-DME-9954714", "R-SPO-9954714", "R-SCE-9954714", "R-CEL-9954714", "R-RNO-9954714", "R-MMU-9954714", "R-HSA-9954714"], "pathways": ["R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "type": "Homologous_superfamily"}, "IPR038070": {"description": "Rv2632c-like superfamily", "go_ids": [], "go_terms": [], "name": "Rv2632c-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038071": {"description": "UROD/MetE-like superfamily", "go_ids": [], "go_terms": [], "name": "UROD/MetE-like_sf", "pathway_ids": ["PWY-7159", "PWY-5531", "PWY-7766", "R-DDI-189451", "R-RNO-189451", "R-DRE-189451", "R-DME-189451", "R-MMU-189451", "R-SCE-189451", "R-SPO-189451", "R-HSA-189451"], "pathways": ["PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)", "PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7766:t:heme b biosynthesis IV (Gram-positive bacteria)", "R-DDI-189451:r:Heme biosynthesis", "R-RNO-189451:r:Heme biosynthesis", "R-DRE-189451:r:Heme biosynthesis", "R-DME-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Homologous_superfamily"}, "IPR038072": {"description": "GspK, central domain superfamily", "go_ids": [], "go_terms": [], "name": "GspK_central_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038073": {"description": "YkuJ-like superfamily", "go_ids": [], "go_terms": [], "name": "YkuJ-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038074": {"description": "YfmB domain superfamily", "go_ids": [], "go_terms": [], "name": "YfmB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038075": {"description": "RalF, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RalF_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038076": {"description": "MgtE, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MgtE_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038077": {"description": "Troponin domain superfamily", "go_ids": [], "go_terms": [], "name": "Troponin_sf", "pathway_ids": ["R-SSC-390522", "R-RNO-390522", "R-CEL-5578775", "R-CFA-390522", "R-DME-5578775", "R-HSA-390522", "R-RNO-5578775", "R-MMU-390522", "R-HSA-5578775", "R-MMU-5578775", "R-BTA-390522"], "pathways": ["R-SSC-390522:r:Striated Muscle Contraction", "R-RNO-390522:r:Striated Muscle Contraction", "R-CEL-5578775:r:Ion homeostasis", "R-CFA-390522:r:Striated Muscle Contraction", "R-DME-5578775:r:Ion homeostasis", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-5578775:r:Ion homeostasis", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-5578775:r:Ion homeostasis", "R-BTA-390522:r:Striated Muscle Contraction"], "type": "Homologous_superfamily"}, "IPR038078": {"description": "PhoU-like domain superfamily", "go_ids": [], "go_terms": [], "name": "PhoU-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038079": {"description": "PA2021-like domain superfamily", "go_ids": [], "go_terms": [], "name": "PA2021-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038080": {"description": "Kinase associated protein B superfamily", "go_ids": [], "go_terms": [], "name": "KapB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038081": {"description": "CalX-like domain superfamily", "go_ids": [], "go_terms": [], "name": "CalX-like_sf", "pathway_ids": ["R-RNO-446107", "R-HSA-3000170", "R-HSA-9725554", "R-HSA-3000157", "R-RNO-5578775", "R-HSA-425561", "R-RNO-418359", "R-MMU-5578775", "R-HSA-9619665", "R-RNO-425561", "R-MMU-3000170", "R-MMU-425561", "R-HSA-8949215", "R-MMU-418359", "R-HSA-2022090", "R-HSA-5578775", "R-HSA-446107", "R-RNO-3000170", "R-MMU-446107", "R-HSA-418359"], "pathways": ["R-RNO-446107:r:Type I hemidesmosome assembly", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-425561:r:Sodium/Calcium exchangers", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-RNO-425561:r:Sodium/Calcium exchangers", "R-MMU-3000170:r:Syndecan interactions", "R-MMU-425561:r:Sodium/Calcium exchangers", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-RNO-3000170:r:Syndecan interactions", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Homologous_superfamily"}, "IPR038082": {"description": "YopT domain superfamily", "go_ids": [], "go_terms": [], "name": "YopT_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038083": {"description": "Non-structural protein NSP3A domain-like superfamily", "go_ids": ["GO:0003727"], "go_terms": ["GO:0003727:single-stranded RNA binding:F"], "name": "NSP3A-like", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR038084": {"description": "Corrinoid adenosyltransferase PduO/GlcC-like superfamily", "go_ids": [], "go_terms": [], "name": "PduO/GlcC-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038085": {"description": "RNase P subunit Pop5/Rpp14/Rnp2-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Rnp2-like_sf", "pathway_ids": ["R-HSA-6791226", "R-MMU-6791226", "R-HSA-6784531"], "pathways": ["R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Homologous_superfamily"}, "IPR038086": {"description": "DUF2789 superfamily", "go_ids": [], "go_terms": [], "name": "DUF2789_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038087": {"description": "DNA-directed RNA polymerase subunit delta, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RNAP_delta_N_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038088": {"description": "DELLA, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DELLA_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038089": {"description": "Mediator of RNA polymerase II, subunit Med31 superfamily", "go_ids": [], "go_terms": [], "name": "Med31_sf", "pathway_ids": ["R-HSA-1989781", "R-BTA-9841922", "R-DME-9841922", "R-HSA-381340", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Homologous_superfamily"}, "IPR038090": {"description": "DNA replication factor Cdt1, C-terminal WH domain superfamily", "go_ids": [], "go_terms": [], "name": "Cdt1_C_WH_dom_sf", "pathway_ids": ["R-MMU-68867", "R-HSA-68949", "R-HSA-69052", "R-HSA-69205", "R-MMU-68962", "R-HSA-68962", "R-SPO-68962", "R-MMU-68949", "R-SPO-68949", "R-MMU-69052", "R-HSA-68867"], "pathways": ["R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-SPO-68949:r:Orc1 removal from chromatin", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Homologous_superfamily"}, "IPR038091": {"description": "Peptidoglycan synthesis regulatory protein ReoY-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ReoY-like_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038092": {"description": "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "PHAX_RNA-binding_sf", "pathway_ids": ["R-HSA-6807505", "R-RNO-6807505", "R-HSA-191859", "R-BTA-6807505", "R-MMU-6807505"], "pathways": ["R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-191859:r:snRNP Assembly", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Homologous_superfamily"}, "IPR038093": {"description": "Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain superfamily", "go_ids": [], "go_terms": [], "name": "USP37-like_PH_sf", "pathway_ids": ["R-MMU-5689880", "R-DRE-5689880", "R-BTA-5689880", "R-HSA-5689880", "R-CFA-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CFA-5689880:r:Ub-specific processing proteases"], "type": "Homologous_superfamily"}, "IPR038094": {"description": "Desulfoferrodoxin, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Desulfoferrodoxin_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038095": {"description": "Costars domain superfamily", "go_ids": [], "go_terms": [], "name": "Costars_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038096": {"description": "TEA/ATTS domain superfamily", "go_ids": [], "go_terms": [], "name": "TEA/ATTS_sf", "pathway_ids": ["R-HSA-2032785", "R-HSA-9819196", "R-HSA-9909649", "R-CEL-2032785", "R-HSA-8951671", "R-DME-2032785", "R-MMU-8951671", "R-DME-390193", "R-HSA-9796292", "R-HSA-9619665", "R-MMU-2032785", "R-CEL-8951671", "R-DME-8951671"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-CEL-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-390193:r:Transcriptional activation by YKI", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-CEL-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-8951671:r:RUNX3 regulates YAP1-mediated transcription"], "type": "Homologous_superfamily"}, "IPR038097": {"description": "Large ribosomal subunit protein eL36 domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_eL36_sf", "pathway_ids": ["R-XTR-6791226", "R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-DRE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-HSA-975956", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-XTR-9954716", "R-CEL-72706", "R-XTR-1799339", "R-GGA-72706", "R-CEL-9954716", "R-CEL-9954714", 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cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR038098": {"description": "PHD finger protein 12, MRG binding domain superfamily", "go_ids": [], "go_terms": [], "name": "PHF12_MRG-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038099": {"description": "BldD-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "BldD-like_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038100": {"description": "NVL2, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NLV2_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038102": {"description": "EYA domain superfamily", "go_ids": [], "go_terms": [], "name": "EYA_dom_sf", "pathway_ids": ["R-HSA-9830674", "R-DME-5693565", "R-BTA-5693565", "R-HSA-5693565", "R-MMU-5693565"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Homologous_superfamily"}, "IPR038103": {"description": "Cell division control protein 73, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CDC73_C_sf", "pathway_ids": ["R-MMU-8866654", "R-RNO-5632684", "R-MMU-5632684", "R-CEL-75955", "R-RNO-674695", "R-RNO-201722", "R-HSA-9920588", "R-RNO-75955", "R-MMU-201722", "R-CEL-201722", "R-RNO-8866654", "R-HSA-5632684", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695", "R-HSA-8866654", "R-CEL-674695", "R-HSA-201722", "R-RNO-112382", "R-HSA-75955", "R-CEL-112382", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-5632684:r:Hedgehog 'on' state", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Homologous_superfamily"}, "IPR038104": {"description": "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Rap1_C_sf", "pathway_ids": ["R-BTA-174411", "R-RNO-174437", "R-HSA-174414", "R-BTA-174437", "R-XTR-171319", "R-BTA-174417", "R-HSA-1221632", "R-RNO-171319", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-XTR-110330", "R-BTA-174430", "R-DRE-110331", "R-DRE-174430", "R-RNO-110330", "R-HSA-110329", "R-XTR-2559586", "R-HSA-110330", "R-BTA-110330", "R-RNO-174411", "R-BTA-9670095", "R-RNO-2559586", "R-HSA-171306", "R-DRE-110330", "R-RNO-174430", "R-BTA-171306", "R-RNO-110331", "R-HSA-174430", "R-HSA-110328", "R-DRE-171319", "R-HSA-174411", "R-DRE-174437", "R-XTR-110331", "R-BTA-171319", "R-BTA-2559586", "R-XTR-171306", "R-HSA-9670095", "R-BTA-110331", "R-GGA-418124", "R-RNO-174417", "R-BTA-174414", "R-HSA-174437", "R-HSA-2559586", "R-RNO-174414"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-171319:r:Telomere Extension By Telomerase", "R-BTA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-1221632:r:Meiotic synapsis", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-XTR-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-DRE-110331:r:Cleavage of the damaged purine", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-XTR-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-BTA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-9670095:r:Inhibition of DNA recombination at telomere", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-DRE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-BTA-171306:r:Packaging Of Telomere Ends", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DRE-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-110331:r:Cleavage of the damaged purine", "R-BTA-171319:r:Telomere Extension By Telomerase", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-XTR-171306:r:Packaging Of Telomere Ends", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-BTA-110331:r:Cleavage of the damaged purine", "R-GGA-418124:r:Telomere maintenance", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere"], "type": "Homologous_superfamily"}, "IPR038105": {"description": "Kinesin-like protein Kif23, Arf6-interacting domain superfamily", "go_ids": [], "go_terms": [], "name": "Kif23_Arf-bd_sf", "pathway_ids": ["R-HSA-2132295", "R-HSA-6811434", "R-HSA-68884", "R-HSA-983189", "R-MMU-2132295", "R-MMU-68884", "R-MMU-983189", "R-MMU-6811434"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-983189:r:Kinesins", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-983189:r:Kinesins", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR038106": {"description": "NFRKB winged helix-like domain superfamily", "go_ids": [], "go_terms": [], "name": "NFRKB_winged_sf", "pathway_ids": ["R-MMU-5696394", "R-HSA-5689603", "R-MMU-5689603", "R-HSA-5696394"], "pathways": ["R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Homologous_superfamily"}, "IPR038107": {"description": "3-deoxy-D-manno-octulosonic-acid transferase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Glycos_transf_N_sf", "pathway_ids": ["PWY-8074", "PWY-8246", "PWY-8284", "PWY-7675"], "pathways": ["PWY-8074:t:Kdo transfer to lipid IVA (P. putida)", "PWY-8246:t:Kdo transfer to lipid IVA (P. gingivalis)", "PWY-8284:t:Kdo transfer to lipid IVA (Vibrio cholerae serogroup O1 El Tor)", "PWY-7675:t:Kdo transfer to lipid IVA (Haemophilus)"], "type": "Homologous_superfamily"}, "IPR038108": {"description": "RPN13, DEUBAD domain superfamily", "go_ids": [], "go_terms": [], "name": "RPN13_DEUBAD_sf", "pathway_ids": ["R-HSA-9931269", "R-MMU-68867", "R-HSA-9929491", "R-DRE-69601", "R-RNO-5689880", "R-DRE-5689603", "R-DRE-9755511", "R-DME-75815", "R-DRE-350562", "R-RNO-8951664", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-MMU-5687128", "R-DRE-4608870", "R-RNO-5358346", "R-DME-5358346", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-DRE-349425", "R-BTA-195253", "R-DRE-8939902", "R-MMU-8852276", "R-BTA-68949", "R-MMU-68949", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-DME-9907900", "R-RNO-4641257", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-DRE-75815", "R-BTA-174184", "R-RNO-349425", "R-MMU-9762114", "R-MMU-195253", "R-MMU-202424", "R-BTA-8939236", "R-HSA-5610780", "R-MMU-382556", "R-BTA-5632684", "R-DRE-174154", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-RNO-75815", "R-MMU-1169091", "R-MMU-5607761", "R-DME-8854050", "R-CEL-5689880", "R-HSA-8939902", "R-DRE-9932298", "R-MMU-8939902", "R-DME-174178", "R-RNO-195253", "R-HSA-8939236", "R-DRE-8854050", "R-BTA-983168", "R-DDI-8854050", "R-MMU-5607764", "R-DRE-5632684", "R-DME-8951664", "R-DRE-8951664", "R-BTA-5668541", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-DRE-1236978", "R-DRE-9954709", "R-DDI-5632684", "R-BTA-9929491", "R-HSA-4641257", "R-RNO-202424", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9929491", "R-RNO-5607761", "R-HSA-68867", "R-DME-174154", "R-MMU-9907900", "R-CEL-4641258", "R-BTA-450408", "R-DDI-5658442", "R-HSA-8941858", "R-HSA-9755511", "R-DRE-1234176", "R-RNO-9931269", "R-CEL-9929491", "R-DME-9755511", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-DRE-5658442", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-RNO-174084", "R-HSA-5689603", "R-RNO-983168", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DME-1169091", "R-DDI-9755511", "R-DME-382556", "R-BTA-8941858", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-HSA-174184", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-DRE-9929491", "R-BTA-2467813", "R-MMU-5610785", "R-DRE-8852276", "R-DRE-69481", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-DRE-5687128", "R-DRE-5689880", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DRE-174084", "R-DRE-450408", "R-DDI-983168", "R-HSA-5668541", "R-HSA-9929356", "R-CEL-69601", "R-CEL-68949", "R-HSA-5687128", "R-DME-5632684", "R-RNO-5658442", "R-MMU-983168", "R-RNO-5610785", "R-HSA-350562", "R-DDI-174178", "R-DME-68867", "R-HSA-174178", "R-DRE-4641258", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-HSA-8951664", "R-BTA-9755511", "R-HSA-9010553", "R-CEL-8941858", "R-HSA-75815", "R-DRE-2467813", "R-MMU-8948751", "R-DME-8948751", "R-DRE-8941858", "R-SPO-5689880", "R-MMU-5689880", "R-CEL-1234176", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-DME-5676590", "R-RNO-8854050", "R-HSA-450408", "R-DRE-69017", "R-RNO-450408", "R-HSA-211733", "R-DME-4641257", "R-HSA-5607761", "R-DDI-174084", "R-DRE-8948751", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DRE-9766229", "R-DDI-4641258", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-CEL-8948751", "R-DRE-5610785", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-DDI-187577", "R-RNO-69481", "R-RNO-9932298", "R-DDI-382556", "R-BTA-1236978", "R-DME-202424", "R-DME-187577", "R-RNO-1234176", "R-DRE-195253", "R-RNO-5632684", "R-MMU-187577", "R-DRE-5610780", "R-RNO-174178", "R-DRE-4641257", "R-BTA-4608870", "R-BTA-5676590", "R-HSA-9824272", "R-MMU-174178", "R-MMU-349425", "R-DRE-983168", "R-BTA-2871837", "R-CEL-8854050", "R-HSA-9907900", "R-BTA-174154", "R-DME-350562", "R-DME-174084", "R-DDI-69601", "R-DME-9929491", "R-HSA-9762114", "R-DDI-5689880", "R-HSA-195253", "R-DRE-174178", "R-DRE-5358346", "R-BTA-187577", "R-CEL-9755511", "R-RNO-9755511", "R-DME-8939236", "R-DME-174184", "R-RNO-174113", "R-BTA-9929356", "R-MMU-5676590", "R-MMU-174184", "R-RNO-187577", "R-RNO-68867", "R-RNO-350562", "R-DME-9932298", "R-RNO-9762114", "R-BTA-9954709", "R-DME-9020702", "R-RNO-69017", "R-CEL-9762114", "R-DME-5689880", "R-HSA-5358346", "R-CEL-8951664", "R-SPO-350562", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-BTA-5610785", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-DDI-1236978", "R-DDI-8951664", "R-MMU-8951664", "R-DME-8939902", "R-CEL-5689603", "R-CEL-382556", "R-RNO-174154", "R-MMU-9929356", "R-DME-4608870", "R-RNO-9929356", "R-HSA-69481", "R-DME-9762114", "R-BTA-174084", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DRE-9907900", "R-HSA-4641258", "R-RNO-8939236", "R-SPO-5689603", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-RNO-174184", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", "R-RNO-2467813", "R-DME-5607764", "R-DME-2871837", "R-DME-8941858", "R-DRE-382556", "R-MMU-5610780", "R-DME-9954709", "R-BTA-382556", "R-DRE-9762114", "R-CEL-8939902", "R-MMU-9755511", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-HSA-5362768", "R-DME-5689603", "R-DDI-9954709", "R-MMU-5658442", "R-RNO-8852276", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-DRE-68949", "R-BTA-8948751", "R-RNO-9907900", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-RNO-5607764", "R-RNO-8941858", "R-HSA-69017", "R-RNO-1169091", "R-BTA-9020702", "R-RNO-9766229", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-DRE-68867", "R-HSA-202424", "R-DDI-174154", "R-CEL-4641257", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-DRE-1169091", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-BTA-1234176", "R-MMU-174154", "R-MMU-69017", "R-CEL-195253", "R-DME-5658442", "R-MMU-9020702", "R-RNO-382556", "R-RNO-5687128", "R-DRE-8939236", "R-MMU-69481", "R-BTA-350562", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-DRE-187577", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-BTA-68867", "R-DRE-5668541", "R-DRE-174184", "R-HSA-1234176", "R-RNO-4641258"], "pathways": ["R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative 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Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DRE-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-9907900:r:Proteasome assembly", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-9907900:r:Proteasome assembly", "R-RNO-4641257:r:Degradation of AXIN", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DRE-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DRE-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DRE-9932298:r:Degradation of CRY and PER proteins", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DRE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-8854050:r:FBXL7 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"R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9907900:r:Proteasome assembly", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-DRE-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5689603:r:UCH proteinases", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DRE-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DRE-69481:r:G2/M Checkpoints", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-DRE-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DRE-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-5632684:r:Hedgehog 'on' state", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-4641258:r:Degradation of DVL", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-DRE-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-69481:r:G2/M Checkpoints", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DRE-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DRE-4641257:r:Degradation of AXIN", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of 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"R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Homologous_superfamily"}, "IPR038122": {"description": "PFU domain superfamily", "go_ids": [], "go_terms": [], "name": "PFU_sf", "pathway_ids": ["R-SPO-983168", "R-SPO-8951664", "R-SCE-983168"], "pathways": ["R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-8951664:r:Neddylation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Homologous_superfamily"}, "IPR038123": {"description": "Non-structural protein NSP4, C-terminal superfamily, coronavirus", "go_ids": [], "go_terms": [], "name": "NSP4_C_sf_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR038124": {"description": "Beta-retroviral matrix superfamily", "go_ids": [], "go_terms": [], "name": "B_retro_matrix_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038125": {"description": "HTHP domain superfamily", "go_ids": [], "go_terms": [], "name": "HTHP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038126": {"description": "RAMP domain superfamily", "go_ids": [], "go_terms": [], "name": "RAMP_sf", "pathway_ids": ["R-RNO-9856530", "R-MMU-419812", "R-HSA-418555", "R-HSA-9856530", "R-RNO-419812", "R-MMU-9856530", "R-MMU-418555", "R-HSA-419812"], "pathways": ["R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-419812:r:Calcitonin-like ligand receptors", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-419812:r:Calcitonin-like ligand receptors", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-419812:r:Calcitonin-like ligand receptors"], "type": "Homologous_superfamily"}, "IPR038127": {"description": "Dinitrogenase iron-molybdenum cofactor, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NafY_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038128": {"description": "Poly-gamma-glutamate hydrolase, zinc-binding motif superfamily", "go_ids": [], "go_terms": [], "name": "Gamma_PGA_hydro_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038129": {"description": "Nanos domain superfamily", "go_ids": [], "go_terms": [], "name": "Nanos_sf", "pathway_ids": ["R-HSA-9827857"], "pathways": ["R-HSA-9827857:r:Specification of primordial germ cells"], "type": "Homologous_superfamily"}, "IPR038130": {"description": "Pleiotrophin/Midkine, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PTN/MK_C_dom_sf", "pathway_ids": ["R-RNO-201556", "R-MMU-201556", "R-XTR-2979096", "R-HSA-2979096", "R-BTA-201556", "R-SSC-9851151", "R-GGA-9851151", "R-HSA-201556", "R-RNO-9851151", "R-XTR-201556", "R-GGA-201556", "R-MMU-9851151", "R-SSC-201556", "R-BTA-9851151", "R-XTR-9851151", "R-HSA-9851151"], "pathways": ["R-RNO-201556:r:Signaling by ALK", "R-MMU-201556:r:Signaling by ALK", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-BTA-201556:r:Signaling by ALK", "R-SSC-9851151:r:MDK and PTN in ALK signaling", "R-GGA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-201556:r:Signaling by ALK", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-XTR-201556:r:Signaling by ALK", "R-GGA-201556:r:Signaling by ALK", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-SSC-201556:r:Signaling by ALK", "R-BTA-9851151:r:MDK and PTN in ALK signaling", "R-XTR-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9851151:r:MDK and PTN in ALK signaling"], "type": "Homologous_superfamily"}, "IPR038131": {"description": "Protein PsiB-like superfamily", "go_ids": [], "go_terms": [], "name": "PsiB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038132": {"description": "Vps16, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Vps16_C_sf", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Homologous_superfamily"}, "IPR038133": {"description": "Ribonuclease III superfamily, archaeal", "go_ids": [], "go_terms": [], "name": "Ribo_III_sf_archaeal", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038134": {"description": "YihD-like superfamily", "go_ids": [], "go_terms": [], "name": "YihD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038135": {"description": "Methylthiotransferase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Methylthiotransferase_N_sf", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Homologous_superfamily"}, "IPR038136": {"description": "CofD-like domain superfamily", "go_ids": [], "go_terms": [], "name": "CofD-like_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038137": {"description": "Excisionase-like superfamily", "go_ids": [], "go_terms": [], "name": "Excisionase-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038138": {"description": "Phosphopantoate/pantothenate synthetase superfamily", "go_ids": [], "go_terms": [], "name": "PPS/PS_sf", "pathway_ids": ["PWY-6654"], "pathways": ["PWY-6654:t:phosphopantothenate biosynthesis III (archaea)"], "type": "Homologous_superfamily"}, "IPR038139": {"description": "NlpE, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NlpE_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038140": {"description": "DotD superfamily", "go_ids": [], "go_terms": [], "name": "DotD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038141": {"description": "YutD-like superfamily", "go_ids": [], "go_terms": [], "name": "YutD-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038142": {"description": "Cytochrome P460 superfamily", "go_ids": [], "go_terms": [], "name": "Cytochrome_P460_sp", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038143": {"description": "NigD-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NigD-like_C_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038144": {"description": "Intracellular proteinase inhibitor", "go_ids": [], "go_terms": [], "name": "IPI", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038145": {"description": "EAGR domain superfamily", "go_ids": [], "go_terms": [], "name": "EAGR_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038146": {"description": "Rac prophage excisionase XisR-like", "go_ids": [], "go_terms": [], "name": "XisR_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038147": {"description": "Cox superfamily", "go_ids": [], "go_terms": [], "name": "Cox_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038148": {"description": "Transposon Tn1545/Tn916, excisionase", "go_ids": [], "go_terms": [], "name": "Tn1545/Tn916_Xis", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038149": {"description": "Scaffold protein B superfamily", "go_ids": [], "go_terms": [], "name": "Phage_B_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038150": {"description": "Protein CHLORORESPIRATORY REDUCTION 7-like superfamily", "go_ids": [], "go_terms": [], "name": "CRR7-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038151": {"description": "Small outer capsid protein superfamily", "go_ids": [], "go_terms": [], "name": "Soc_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038152": {"description": "Carbamoyltransferase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Carbam_trans_C_sf", "pathway_ids": ["PWY-8344", "PWY-7694", "PWY-7693", "PWY-8039", "PWY-5"], "pathways": ["PWY-8344:t:ansamitocin P biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-5:t:canavanine biosynthesis"], "type": "Homologous_superfamily"}, "IPR038153": {"description": "dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase superfamily", "go_ids": [], "go_terms": [], "name": "EvaA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038154": {"description": "Arterivirus papain-like cysteine protease beta (PCPbeta) domain superfamily", "go_ids": ["GO:0008234"], "go_terms": ["GO:0008234:cysteine-type peptidase activity:F"], "name": "AV_PCPbeta_sf", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR038155": {"description": "Arterivirus papain-like cysteine protease alpha (PCPalpha) domain superfamily", "go_ids": ["GO:0004197"], "go_terms": ["GO:0004197:cysteine-type endopeptidase activity:F"], "name": "AV_PCPalpha_sf", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR038156": {"description": "Phytochelatin synthase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PCS_N_sf", "pathway_ids": ["PWY-6745"], "pathways": ["PWY-6745:t:phytochelatins biosynthesis"], "type": "Homologous_superfamily"}, "IPR038157": {"description": "Ferrous iron transporter, core domain", "go_ids": [], "go_terms": [], "name": "FeoA_core_dom", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Homologous_superfamily"}, "IPR038158": {"description": "H-NOX domain superfamily", "go_ids": ["GO:0020037"], "go_terms": ["GO:0020037:heme binding:F"], "name": "H-NOX_domain_sf", "pathway_ids": ["R-BTA-445355", "R-HSA-445355", "R-RNO-445355", "R-HSA-392154", "R-MMU-445355", "R-DME-445355"], "pathways": ["R-BTA-445355:r:Smooth Muscle Contraction", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-445355:r:Smooth Muscle Contraction", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction"], "type": "Homologous_superfamily"}, "IPR038160": {"description": "6-Cysteine (6-Cys) domain superfamily", "go_ids": [], "go_terms": [], "name": "6_CYS_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038161": {"description": "VirB9/CagX/TrbG, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "VirB9/CagX/TrbG_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038162": {"description": "Ig-like SoxY domain superfamily", "go_ids": [], "go_terms": [], "name": "SoxY_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038163": {"description": "Drosophila transcription factor p53, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Dro_p53_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038164": {"description": "Pab87 octamerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "Pab87_oct_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038165": {"description": "FlgT, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "FlgT_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038166": {"description": "Polyprotein cleavage domain PL2pro superfamily, betacoronavirus", "go_ids": [], "go_terms": [], "name": "NSP3_PL2pro_sf_bCoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR038167": {"description": "SSRP1 domain superfamily", "go_ids": [], "go_terms": [], "name": "SSRP1_sf", "pathway_ids": ["R-SPO-674695", "R-RNO-674695", "R-HSA-167238", "R-MMU-6804756", "R-DME-6796648", "R-SCE-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-DDI-674695", "R-HSA-167152", "R-DDI-6796648", "R-DDI-6804756", "R-CEL-6804756", "R-RNO-6804756", "R-SPO-6796648", "R-SCE-6796648", "R-CEL-75955", "R-MMU-6796648", "R-DME-674695", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-HSA-6804756", "R-HSA-167290", "R-RNO-112382", "R-CEL-112382", "R-HSA-75955", "R-SCE-674695", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Homologous_superfamily"}, "IPR038168": {"description": "Transcription factor DP, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "TF_DP_C_sf", "pathway_ids": ["R-MMU-8953750", "R-BTA-69231", "R-HSA-2559580", "R-HSA-69205", "R-DME-69231", "R-HSA-2559585", "R-HSA-69231", "R-HSA-8953750", "R-BTA-2173796", "R-HSA-139915", "R-HSA-1912408", "R-MMU-1538133", "R-HSA-69656", "R-CEL-1538133", "R-HSA-1538133", "R-DME-8953750", "R-HSA-9616222", "R-BTA-8953750", "R-CEL-69231", "R-HSA-2173796", "R-BTA-1538133", "R-HSA-113501", "R-HSA-9661069", "R-HSA-1362300", "R-MMU-2173796", "R-CEL-2173796", "R-DME-1538133", "R-HSA-1362277", "R-HSA-6804114", "R-HSA-111448", "R-DME-2173796", "R-CEL-8953750", "R-HSA-69202", "R-MMU-69231"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-69231:r:Cyclin D associated events in G1", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-69205:r:G1/S-Specific Transcription", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-1538133:r:G0 and Early G1", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-CEL-69231:r:Cyclin D associated events in G1", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-1538133:r:G0 and Early G1", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-1538133:r:G0 and Early G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Homologous_superfamily"}, "IPR038169": {"description": "DC-UbP/UBTD2, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DC-UbP/UBTD2_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038170": {"description": "NS5A domain 1a superfamily", "go_ids": [], "go_terms": [], "name": "NS5A_1a_sf", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Homologous_superfamily"}, "IPR038171": {"description": "Peptidase M64, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "M64_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038172": {"description": "Herpesvirus glycoprotein H, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Herpes_glycoH_C_sf", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Homologous_superfamily"}, "IPR038173": {"description": "Transcription factor COE, DNA-binding domain superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "COE_DBD_sf", "pathway_ids": ["R-HSA-9844594", "R-HSA-9752946", "R-HSA-381340"], "pathways": ["R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Homologous_superfamily"}, "IPR038174": {"description": "Streptococcal pilin isopeptide linker superfamily", "go_ids": [], "go_terms": [], "name": "Strep_pil_link_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038175": {"description": "CBM21 domain superfamily", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "CBM21_dom_sf", "pathway_ids": ["R-SCE-3322077", "R-HSA-3785653", "R-BTA-3322077", "R-MMU-3322077", "R-DRE-3322077", "R-DME-3322077", "R-RNO-3322077", "R-HSA-3322077"], "pathways": ["R-SCE-3322077:r:Glycogen synthesis", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-3322077:r:Glycogen synthesis", "R-MMU-3322077:r:Glycogen synthesis", "R-DRE-3322077:r:Glycogen synthesis", "R-DME-3322077:r:Glycogen synthesis", "R-RNO-3322077:r:Glycogen synthesis", "R-HSA-3322077:r:Glycogen synthesis"], "type": "Homologous_superfamily"}, "IPR038176": {"description": "Fragilysin, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Fragilysin_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038177": {"description": "Inverse autotransporter, beta-domain superfamily", "go_ids": [], "go_terms": [], "name": "IAT_beta_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038178": {"description": "Kringle superfamily", "go_ids": [], "go_terms": [], "name": "Kringle_sf", "pathway_ids": ["R-HSA-186797", "R-HSA-6798695", "R-MMU-416476", "R-HSA-8874081", "R-HSA-8875555", "R-HSA-159782", "R-MMU-159740", "R-MMU-76009", "R-MMU-6811558", "R-HSA-140837", "R-RNO-140875", "R-BTA-6798695", "R-MMU-8875791", "R-MMU-375276", "R-RNO-3772470", "R-CFA-9734091", "R-MMU-8865999", "R-CFA-114608", "R-HSA-6806942", "R-RNO-140837", "R-RNO-977606", "R-CFA-1257604", "R-MMU-456926", "R-CFA-8851805", "R-RNO-6811558", "R-MMU-8851805", "R-RNO-202733", "R-CFA-6807004", "R-MMU-202733", "R-CFA-5673001", "R-HSA-9672391", "R-HSA-8875513", "R-CFA-186797", "R-HSA-5140745", "R-CFA-8851907", "R-RNO-8865999", "R-HSA-75205", "R-HSA-1266695", "R-HSA-381426", "R-RNO-5673001", "R-RNO-159740", "R-RNO-416476", "R-MMU-5673001", "R-HSA-1474228", "R-RNO-6806942", "R-MMU-1592389", "R-CFA-8874081", "R-HSA-456926", "R-DME-5140745", "R-RNO-159763", "R-MMU-140837", "R-CFA-8875513", "R-HSA-2219530", "R-HSA-6785807", "R-MMU-5140745", "R-GGA-6798695", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-381426", "R-HSA-159740", "R-RNO-456926", "R-MMU-8875555", "R-CFA-8875555", "R-RNO-8875656", "R-RNO-8851805", "R-CFA-6806942", "R-CFA-8875656", "R-MMU-6798695", "R-MMU-8875513", "R-RNO-8875555", "R-HSA-1257604", "R-MMU-186797", "R-HSA-8865999", "R-RNO-6798695", "R-RNO-8851907", "R-MMU-114608", "R-CFA-8875791", "R-HSA-9657688", "R-HSA-201681", "R-MMU-3772470", "R-HSA-9657689", "R-HSA-375276", "R-RNO-1257604", "R-RNO-159782", "R-HSA-416476", "R-RNO-9734091", "R-RNO-114608", "R-RNO-8874081", "R-RNO-8875513", "R-HSA-114608", "R-HSA-76009", "R-MMU-8852405", "R-MMU-8874081", "R-CEL-5140745", "R-HSA-977606", "R-HSA-8851907", "R-CFA-6811558", "R-MMU-159763", "R-RNO-75205", "R-HSA-8851805", "R-HSA-9918481", "R-MMU-9734091", "R-HSA-159763", "R-HSA-9734091", "R-HSA-3772470", "R-HSA-8875791", "R-HSA-8852405", "R-CFA-1592389", "R-MMU-977606", "R-RNO-1592389", "R-RNO-8875791", "R-HSA-5339717", "R-HSA-4086400", "R-RNO-186797", "R-MMU-75205", "R-HSA-1592389", "R-HSA-6807004", "R-MMU-1257604", "R-SSC-75205", "R-HSA-140875", "R-HSA-8964041", "R-MMU-140875", "R-RNO-6807004", "R-MMU-6806942", "R-CFA-8865999", "R-RNO-375276", "R-MMU-159782", "R-MMU-8851907", "R-CFA-75205", "R-BTA-75205", "R-MMU-8875656", "R-MMU-6807004", "R-HSA-8875656", "R-HSA-202733", "R-SSC-186797"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-8875791:r:MET activates STAT3", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-CFA-9734091:r:Drug-mediated inhibition of MET activation", "R-MMU-8865999:r:MET activates PTPN11", "R-CFA-114608:r:Platelet degranulation", "R-HSA-6806942:r:MET Receptor Activation", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-977606:r:Regulation of Complement cascade", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-CFA-8851805:r:MET activates RAS signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CFA-6807004:r:Negative regulation of MET activity", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-CFA-186797:r:Signaling by PDGF", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-CFA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-8865999:r:MET activates PTPN11", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-416476:r:G alpha (q) signalling events", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-6806942:r:MET Receptor Activation", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-CFA-8874081:r:MET activates PTK2 signaling", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-CFA-8875513:r:MET interacts with TNS proteins", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-CFA-8875555:r:MET activates RAP1 and RAC1", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-8851805:r:MET activates RAS signaling", "R-CFA-6806942:r:MET Receptor Activation", "R-CFA-8875656:r:MET receptor recycling", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-186797:r:Signaling by PDGF", "R-HSA-8865999:r:MET activates PTPN11", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-114608:r:Platelet degranulation", "R-CFA-8875791:r:MET activates STAT3", "R-HSA-9657688:r:Defective factor XII causes hereditary angioedema", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-8852405:r:Signaling by MST1", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-8852405:r:Signaling by MST1", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-8875791:r:MET activates STAT3", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-HSA-4086400:r:PCP/CE pathway", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SSC-75205:r:Dissolution of Fibrin Clot", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-8964041:r:LDL remodeling", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-6806942:r:MET Receptor Activation", "R-CFA-8865999:r:MET activates PTPN11", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-75205:r:Dissolution of Fibrin Clot", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-8875656:r:MET receptor recycling", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-SSC-186797:r:Signaling by PDGF"], "type": "Homologous_superfamily"}, "IPR038179": {"description": "NigD-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NigD-like_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038180": {"description": "FlgT, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "FlgT_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038181": {"description": "Novel toxin 21 superfamily", "go_ids": [], "go_terms": [], "name": "Ntox21_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038182": {"description": "HMD, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "HMD_C_sf", "pathway_ids": ["PWY-7784"], "pathways": ["PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)"], "type": "Homologous_superfamily"}, "IPR038183": {"description": "RICH domain superfamily", "go_ids": [], "go_terms": [], "name": "RICH_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038184": {"description": "CSTF1, dimerization domain superfamily", "go_ids": [], "go_terms": [], "name": "CSTF1_dimer_sf", "pathway_ids": ["R-RNO-73856", "R-HSA-77595", "R-MMU-72187", "R-HSA-9770562", "R-MMU-9770562", "R-RNO-9770562", "R-MMU-77595", "R-HSA-73856", "R-RNO-77595", "R-MMU-73856", "R-HSA-72187", "R-HSA-9918481"], "pathways": ["R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Homologous_superfamily"}, "IPR038185": {"description": "MyTH4 domain superfamily", "go_ids": [], "go_terms": [], "name": "MyTH4_dom_sf", "pathway_ids": ["R-HSA-9013405", "R-MMU-9035034", "R-HSA-9664422", "R-MMU-9013106", "R-MMU-8980692", "R-HSA-9662361", "R-MMU-9013408", "R-MMU-2453902", "R-CEL-2453902", "R-MMU-9013148", "R-MMU-9013404", "R-HSA-9013106", "R-HSA-373752", "R-HSA-2029482", "R-MMU-2029482", "R-DDI-9013422", "R-RNO-2029482", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-428543", "R-HSA-8980692", "R-HSA-9662360", "R-DME-2453902", "R-HSA-9035034", "R-MMU-9013026", "R-HSA-9013148", "R-HSA-9013026", "R-HSA-9013408", "R-MMU-9013149", "R-DDI-9013418", "R-HSA-2453902"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Homologous_superfamily"}, "IPR038186": {"description": "CHAD domain superfamily", "go_ids": [], "go_terms": [], "name": "CHAD_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038187": {"description": "NAC A/B domain superfamily", "go_ids": [], "go_terms": [], "name": "NAC_A/B_dom_sf", "pathway_ids": ["R-HSA-9918487"], "pathways": ["R-HSA-9918487:r:Dengue Virus Genome Translation and Replication"], "type": "Homologous_superfamily"}, "IPR038188": {"description": "TorS, sensor domain superfamily", "go_ids": [], "go_terms": [], "name": "TorS_sensor_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038189": {"description": "Cdc37, Hsp90-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Cdc37_Hsp90-bd_sf", "pathway_ids": ["R-MMU-8863795", "R-DRE-114608", "R-CEL-8863795", "R-CEL-1227986", "R-HSA-9013418", "R-CEL-9652282", "R-HSA-9665251", "R-BTA-1227986", "R-BTA-9652282", "R-DME-9652282", "R-HSA-9665737", "R-SCE-114608", "R-HSA-9665348", "R-SPO-114608", "R-HSA-9665245", "R-RNO-8863795", "R-RNO-114608", "R-HSA-114608", "R-BTA-114608", "R-HSA-8863795", "R-BTA-5675482", "R-HSA-1236382", "R-MMU-9652282", "R-BTA-9013418", "R-DME-8863795", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-9652282", "R-BTA-8863795", "R-RNO-9013418", "R-DME-1227986", "R-HSA-9665244", "R-HSA-9665686", "R-HSA-9665249", "R-HSA-9665246", "R-HSA-5675482", "R-DME-114608", "R-MMU-1227986", "R-HSA-1227986", "R-CEL-114608", "R-HSA-9665233", "R-MMU-5675482", "R-RNO-1227986", "R-HSA-9665250", "R-HSA-5637810", "R-DME-9013418", "R-SPO-9652282", "R-CEL-5675482", "R-HSA-9634285", "R-RNO-9652282", "R-RNO-5675482", "R-MMU-9013418", "R-MMU-114608"], "pathways": ["R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DRE-114608:r:Platelet degranulation", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-1227986:r:Signaling by ERBB2", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-CEL-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-BTA-1227986:r:Signaling by ERBB2", "R-BTA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-SCE-114608:r:Platelet degranulation", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-SPO-114608:r:Platelet degranulation", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-DME-114608:r:Platelet degranulation", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-1227986:r:Signaling by ERBB2", "R-CEL-114608:r:Platelet degranulation", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-CEL-5675482:r:Regulation of necroptotic cell death", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR038190": {"description": "Set2 Rpb1 interacting domain superfamily", "go_ids": [], "go_terms": [], "name": "SRI_sf", "pathway_ids": ["R-MMU-3214841", "R-HSA-3214841"], "pathways": ["R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines"], "type": "Homologous_superfamily"}, "IPR038191": {"description": "YciN superfamily", "go_ids": [], "go_terms": [], "name": "YciN_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038192": {"description": "Transcription termination and cleavage factor, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CSTF_C_sf", "pathway_ids": ["R-HSA-9770562", "R-MMU-9770562", "R-HSA-6784531", "R-MMU-77595", "R-HSA-73856", "R-MMU-73856", "R-BTA-73856", "R-HSA-72187", "R-HSA-77595", "R-SPO-9770562", "R-MMU-72187", "R-BTA-9770562", "R-HSA-9918481", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Homologous_superfamily"}, "IPR038193": {"description": "Mistic superfamily", "go_ids": [], "go_terms": [], "name": "Mistic_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038194": {"description": "DUF3861 domain superfamily", "go_ids": [], "go_terms": [], "name": "DUF3861_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038195": {"description": "Apolipoprotein CIII superfamily", "go_ids": [], "go_terms": [], "name": "Apo_CIII_sf", "pathway_ids": ["R-SSC-8963888", "R-RNO-8963901", "R-MMU-8963888", "R-HSA-8964058", "R-BTA-8963901", "R-HSA-8963901", "R-HSA-8963888", "R-BTA-975634", "R-BTA-8963888", "R-SSC-8963901", "R-MMU-8963901", "R-MMU-8964058", "R-RNO-8963888", "R-MMU-975634", "R-SSC-975634", "R-RNO-975634", "R-SSC-8964058", "R-RNO-8964058", "R-HSA-975634", "R-BTA-8964058"], "pathways": ["R-SSC-8963888:r:Chylomicron assembly", "R-RNO-8963901:r:Chylomicron remodeling", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-8964058:r:HDL remodeling", "R-BTA-8963901:r:Chylomicron remodeling", "R-HSA-8963901:r:Chylomicron remodeling", "R-HSA-8963888:r:Chylomicron assembly", "R-BTA-975634:r:Retinoid metabolism and transport", "R-BTA-8963888:r:Chylomicron assembly", "R-SSC-8963901:r:Chylomicron remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-MMU-8964058:r:HDL remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-MMU-975634:r:Retinoid metabolism and transport", "R-SSC-975634:r:Retinoid metabolism and transport", "R-RNO-975634:r:Retinoid metabolism and transport", "R-SSC-8964058:r:HDL remodeling", "R-RNO-8964058:r:HDL remodeling", "R-HSA-975634:r:Retinoid metabolism and transport", "R-BTA-8964058:r:HDL remodeling"], "type": "Homologous_superfamily"}, "IPR038196": {"description": "Mediator complex subunit 25, PTOV domain superfamily", "go_ids": [], "go_terms": [], "name": "Med25_PTOV_sf", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Homologous_superfamily"}, "IPR038197": {"description": "TbpB, C-lobe handle domain superfamily", "go_ids": [], "go_terms": [], "name": "TbpB_C-lobe_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038198": {"description": "MukF, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MukF_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038199": {"description": "DGK type I, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DGK_typeI_N_sf", "pathway_ids": ["PWY-7039", "PWY-7817", "R-MMU-114508", "R-SSC-114508", "R-BTA-114508", "R-HSA-114508", "R-RNO-114508", "R-DME-114508", "R-CEL-114508"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-SSC-114508:r:Effects of PIP2 hydrolysis", "R-BTA-114508:r:Effects of PIP2 hydrolysis", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-CEL-114508:r:Effects of PIP2 hydrolysis"], "type": "Homologous_superfamily"}, "IPR038200": {"description": "GW domain superfamily", "go_ids": [], "go_terms": [], "name": "GW_dom_sf", "pathway_ids": ["PWY-7883", "R-HSA-8875360"], "pathways": ["PWY-7883:t:peptidoglycan recycling II", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell"], "type": "Homologous_superfamily"}, "IPR038201": {"description": "PrgU-like superfamily", "go_ids": [], "go_terms": [], "name": "PrgU-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038202": {"description": "Regulatory protein cro superfamily", "go_ids": [], "go_terms": [], "name": "Cro_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038203": {"description": "Diapausin superfamily", "go_ids": [], "go_terms": [], "name": "Diapausin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038204": {"description": "Antibacterial factor-related peptide superfamily", "go_ids": [], "go_terms": [], "name": "Abf-1/2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038205": {"description": "Protein inscuteable homologue, LGN-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "INSC_LBD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038207": {"description": "DIX domain superfamily", "go_ids": [], "go_terms": [], "name": "DIX_dom_sf", "pathway_ids": ["R-RNO-201681", "R-MMU-8856828", "R-DME-209155", "R-HSA-8939256", "R-HSA-8856828", "R-HSA-5689880", "R-XTR-8856825", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-195253", "R-XTR-4641262", "R-DME-4086400", "R-DME-350376", "R-MMU-5689880", "R-DME-5099900", "R-CEL-4641257", "R-HSA-5358747", "R-RNO-196299", "R-DME-350411", "R-DME-4641262", "R-DRE-4641262", "R-HSA-4641257", "R-HSA-5467337", "R-XTR-5099900", "R-DME-5663220", "R-DME-4608870", "R-HSA-9018519", "R-DME-209413", "R-HSA-5358752", "R-RNO-4641258", "R-HSA-5358749", "R-HSA-8931987", "R-MMU-196299", "R-CEL-4641258", "R-DME-350369", "R-DME-4641257", "R-RNO-4086400", "R-DME-209461", "R-MMU-4086400", "R-CEL-4086400", "R-MMU-201681", "R-XTR-4641258", "R-RNO-5663220", "R-HSA-4641258", "R-HSA-5467340", "R-RNO-5689880", "R-DRE-196299", "R-MMU-4641258", "R-HSA-4608870", "R-XTR-4086400", "R-MMU-4641257", "R-MMU-4641262", "R-CEL-8856825", "R-MMU-5663220", "R-XTR-2028269", "R-RNO-201688", "R-HSA-5358751", "R-HSA-201681", "R-DME-432553", "R-RNO-4641262", "R-DRE-195253", "R-CEL-5663220", "R-MMU-8856825", "R-HSA-5368598", "R-HSA-5467348", "R-DME-4641258", "R-DME-350368", "R-MMU-201688", "R-DRE-4641257", "R-DME-2028269", "R-DME-195253", "R-HSA-196299", "R-DME-209214", "R-RNO-4641257", "R-DME-209396", "R-HSA-5339716", "R-HSA-4641262", "R-MMU-4608870", "R-DME-450728", "R-MMU-195253", "R-HSA-195253", "R-XTR-8856828", "R-CEL-8856828", "R-DME-209190", "R-DME-209360", "R-HSA-201688", "R-MMU-2028269", "R-HSA-4086400", "R-XTR-201688", "R-HSA-5099900", "R-XTR-5663220", "R-DME-350480", "R-DME-196299", "R-HSA-9673324", "R-DME-201688", "R-CEL-2028269", "R-CEL-201688", "R-CEL-196299", "R-DME-209440", "R-HSA-8856825", "R-HSA-5663220", "R-HSA-4411364", "R-RNO-195253", "R-HSA-2028269"], "pathways": ["R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5689880:r:Ub-specific processing proteases", "R-XTR-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-XTR-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-4086400:r:PCP/CE pathway", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-CEL-4641257:r:Degradation of AXIN", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-4641258:r:Degradation of DVL", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-DME-4641257:r:Degradation of AXIN", "R-RNO-4086400:r:PCP/CE pathway", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-4086400:r:PCP/CE pathway", "R-CEL-4086400:r:PCP/CE pathway", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-XTR-4641258:r:Degradation of DVL", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-XTR-4086400:r:PCP/CE pathway", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-XTR-2028269:r:Signaling by Hippo", "R-RNO-201688:r:WNT mediated activation of DVL", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-DME-4641258:r:Degradation of DVL", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-MMU-201688:r:WNT mediated activation of DVL", "R-DRE-4641257:r:Degradation of AXIN", "R-DME-2028269:r:Signaling by Hippo", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-DME-209214:r:Phosphorylation of SMO", "R-RNO-4641257:r:Degradation of AXIN", "R-DME-209396:r:Phosphorylation of ARM", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DME-209190:r:Phosphorylation of CI", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-HSA-201688:r:WNT mediated activation of DVL", "R-MMU-2028269:r:Signaling by Hippo", "R-HSA-4086400:r:PCP/CE pathway", "R-XTR-201688:r:WNT mediated activation of DVL", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-DME-201688:r:WNT mediated activation of DVL", "R-CEL-2028269:r:Signaling by Hippo", "R-CEL-201688:r:WNT mediated activation of DVL", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-2028269:r:Signaling by Hippo"], "type": "Homologous_superfamily"}, "IPR038208": {"description": "Sigma factor-binding protein Crl superfamily", "go_ids": ["GO:0045893"], "go_terms": ["GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "Tscrpt_reg_Crl_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038209": {"description": "CKK domain superfamily", "go_ids": [], "go_terms": [], "name": "CKK_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038211": {"description": "Ant venom allergen, Sol i 2/4 superfamily", "go_ids": [], "go_terms": [], "name": "Ant_venon_allerg_soli_2/4_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038212": {"description": "Transcription factor EnY2 superfamily", "go_ids": [], "go_terms": [], "name": "TF_EnY2_sf", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Homologous_superfamily"}, "IPR038213": {"description": "IFI6/IFI27-like domain superfamily", "go_ids": [], "go_terms": [], "name": "IFI6/IFI27-like_sf", "pathway_ids": ["R-HSA-909733", "R-BTA-9909505", "R-HSA-9909505"], "pathways": ["R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes"], "type": "Homologous_superfamily"}, "IPR038214": {"description": "WPP domain superfamily", "go_ids": [], "go_terms": [], "name": "WPP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038215": {"description": "Transposase, Tn5-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "TN5-like_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038216": {"description": "SATB, CUTL domain superfamily", "go_ids": [], "go_terms": [], "name": "SATB_CUTL_sf", "pathway_ids": ["R-MMU-4551638", "R-MMU-111465", "R-HSA-4551638", "R-HSA-8940973", "R-HSA-111465"], "pathways": ["R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Homologous_superfamily"}, "IPR038217": {"description": "MRG, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MRG_C_sf", "pathway_ids": ["R-MMU-3214847", "R-HSA-3214847", "R-DME-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones"], "type": "Homologous_superfamily"}, "IPR038218": {"description": "YuzD-like superfamily", "go_ids": [], "go_terms": [], "name": "YuzD-like_sp", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038219": {"description": "Selenoprotein F/M, thioredoxin-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Sep15/SelM_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038220": {"description": "Phenol hydroxylase, C-terminal TRX-fold domain superfamily", "go_ids": [], "go_terms": [], "name": "PHOX_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038221": {"description": "YidC, periplasmic domain superfamily", "go_ids": [], "go_terms": [], "name": "YidC_periplasmic_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038222": {"description": "DHHA2 domain superfamily", "go_ids": [], "go_terms": [], "name": "DHHA2_dom_sf", "pathway_ids": ["PWY-7807", "PWY-7805"], "pathways": ["PWY-7807:t:glyphosate degradation III", "PWY-7805:t:(aminomethyl)phosphonate degradation"], "type": "Homologous_superfamily"}, "IPR038223": {"description": "DNA-mimic protein DMP12 superfamily", "go_ids": [], "go_terms": [], "name": "DMP12_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038224": {"description": "SATB, ULD domain superfamily", "go_ids": [], "go_terms": [], "name": "SATB_ULD_sf", "pathway_ids": ["R-MMU-4551638", "R-MMU-111465", "R-HSA-4551638", "R-HSA-8940973", "R-CEL-4551638", "R-HSA-111465"], "pathways": ["R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Homologous_superfamily"}, "IPR038225": {"description": "T6S-associated protein TagF superfamily", "go_ids": [], "go_terms": [], "name": "TagF_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038226": {"description": "LMG 18311 protein-like superfamily", "go_ids": [], "go_terms": [], "name": "LMG18311-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038227": {"description": "PCGF Ub-like fold discriminator superfamily", "go_ids": [], "go_terms": [], "name": "PUFD_som_sf", 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"Homologous_superfamily"}, "IPR038233": {"description": "Colicin D/E5 nuclease domain superfamily", "go_ids": [], "go_terms": [], "name": "Colicin_D/E5_nuclease", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038234": {"description": "Colicin E5 ribonuclease domain superfamily", "go_ids": [], "go_terms": [], "name": "Colicin_E5_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038235": {"description": "Respiratory growth induced protein 1 superfamily", "go_ids": [], "go_terms": [], "name": "RGI1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038236": {"description": "GlpG peptidase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "GlpG_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038237": {"description": "Small ribosomal subunit protein eS4, central domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_eS4_central_sf", 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"R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a 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"R-XTR-9770562", "R-MMU-9770562", "R-HSA-6784531", "R-MMU-77595", "R-BTA-73856", "R-RNO-77595", "R-HSA-73856", "R-DDI-9770562", "R-CEL-73856", "R-MMU-73856", "R-HSA-72187", "R-CEL-77595", "R-RNO-73856", "R-SCE-9770562", "R-SPO-9770562", "R-DME-9770562", "R-HSA-77595", "R-DRE-73856", "R-MMU-72187", "R-DRE-9770562", "R-CEL-9770562", "R-RNO-9770562", "R-BTA-9770562", "R-GGA-9770562", "R-DME-73856", "R-HSA-9918481", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription 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"R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-SCE-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-DRE-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-GGA-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Homologous_superfamily"}, "IPR038240": {"description": "Stn1, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Stn1_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038241": {"description": "Endoribonuclease antitoxin GhoS superfamily", "go_ids": ["GO:0004521"], "go_terms": ["GO:0004521:RNA endonuclease activity:F"], "name": "GhoS_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038242": {"description": "CRISPR-Cas system, Cmr2 subunit, D1 domain, cysteine cluster", "go_ids": [], "go_terms": [], "name": "Cmr2_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038243": {"description": "Spidroin, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Spidroin_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038244": {"description": "Rhomboid protease, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NRho_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038245": {"description": "MogR, DNA-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "MogR_DNA-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038246": {"description": "Phi-29-like late genes activator superfamily", "go_ids": [], "go_terms": [], "name": "Phi-29-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038247": {"description": "Jag, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Jag_N_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038248": {"description": "Dicer dimerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "Dicer_dimer_sf", "pathway_ids": ["R-CEL-426486", "R-MMU-426486", "R-HSA-426486", "R-DME-203927", "R-MMU-203927", "R-HSA-9824594", "R-HSA-203927", "R-XTR-426486", "R-CEL-203927", "R-HSA-9820841", "R-HSA-9708296", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Homologous_superfamily"}, "IPR038249": {"description": "DNA polymerase III, tau subunit, domain V superfamily", "go_ids": [], "go_terms": [], "name": "PolIII_tau_V_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038250": {"description": "TGT, patch-forming C2 domain superfamily", "go_ids": [], "go_terms": [], "name": "TGT_C2_sf", "pathway_ids": ["PWY-6711", "PWY-7923"], "pathways": ["PWY-6711:t:archaeosine biosynthesis I", "PWY-7923:t:archaeosine biosynthesis II"], "type": "Homologous_superfamily"}, "IPR038251": {"description": "PdxB, dimerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "PdxB_dimer_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038252": {"description": "Ubiquitin-activating enzyme E1, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "UBA_E1_C_sf", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-MMU-9909505", "R-HSA-168928", "R-DDI-936440", "R-HSA-9918485", "R-MMU-5656169", "R-RNO-8866652", "R-HSA-936440", "R-HSA-983168", "R-HSA-1169408", "R-MMU-8866652", "R-MMU-1169408", "R-HSA-9909505", "R-DDI-983168", "R-HSA-8866652", "R-DDI-9909505", "R-BTA-8866652", "R-MMU-983168", "R-SPO-983168", "R-RNO-983168", "R-SCE-983168", "R-HSA-5656169", "R-DDI-1169408", "R-DDI-8866652"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "type": "Homologous_superfamily"}, "IPR038253": {"description": "SRP68, N-terminal domain superfamily", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "SRP68_N_sf", "pathway_ids": ["R-HSA-1799339", "R-MMU-1799339", "R-DME-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-CEL-1799339", "R-SPO-1799339", "R-SCE-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Homologous_superfamily"}, "IPR038254": {"description": "DNA/RNA-binding protein KIN17, WH-like domain superfamily", "go_ids": [], "go_terms": [], "name": "KIN17_WH-like_sf", "pathway_ids": ["R-HSA-8876725", "R-MMU-8876725"], "pathways": ["R-HSA-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation"], "type": "Homologous_superfamily"}, "IPR038255": {"description": "Phycobilisome linker domain superfamily", "go_ids": [], "go_terms": [], "name": "PBS_linker_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038256": {"description": "DNA polymerase alpha, zinc finger domain superfamily", "go_ids": [], "go_terms": [], "name": "Pol_alpha_znc_sf", "pathway_ids": ["R-MMU-174430", "R-RNO-68962", "R-HSA-69205", "R-SCE-69091", "R-DME-113501", "R-RNO-69183", "R-DME-68962", "R-RNO-69166", "R-DDI-68952", "R-DDI-68962", "R-SPO-69091", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-RNO-68952", "R-RNO-174411", "R-SCE-68952", "R-SPO-69166", "R-HSA-113501", "R-HSA-68952", "R-SCE-69183", "R-DDI-113501", "R-DDI-69091", "R-MMU-68962", "R-DDI-69183", "R-RNO-174430", "R-HSA-174430", "R-SPO-69183", "R-MMU-113501", "R-DME-69091", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-SCE-113501", "R-SCE-68962", "R-DDI-69166", "R-RNO-69091", "R-HSA-9710421", "R-MMU-68952", "R-RNO-113501", "R-SPO-113501", "R-SPO-68952", "R-HSA-69183", "R-SCE-69166", "R-MMU-69166", "R-SPO-68962", "R-HSA-69091", "R-MMU-174411", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-SCE-69091:r:Polymerase switching", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-DME-68962:r:Activation of the pre-replicative complex", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-DDI-68952:r:DNA replication initiation", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-69091:r:Polymerase switching", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-RNO-68952:r:DNA replication initiation", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-SCE-68952:r:DNA replication initiation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-68952:r:DNA replication initiation", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DDI-69091:r:Polymerase switching", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-69091:r:Polymerase switching", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DDI-69166:r:Removal of the Flap Intermediate", "R-RNO-69091:r:Polymerase switching", "R-HSA-9710421:r:Defective pyroptosis", "R-MMU-68952:r:DNA replication initiation", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-68952:r:DNA replication initiation", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-69091:r:Polymerase switching", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Homologous_superfamily"}, "IPR038257": {"description": "CRISPR-associated Cas3-type HD domain superfamily", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Cas3_HD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038258": {"description": "Peptidoglycan hydrolase Gp4 superfamily", "go_ids": [], "go_terms": [], "name": "Gp4_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038259": {"description": "Tmem141 superfamily", "go_ids": [], "go_terms": [], "name": "Tmem141_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038260": {"description": "Vps53, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Vps53_C_sf", "pathway_ids": ["R-HSA-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Homologous_superfamily"}, "IPR038261": {"description": "Golgi phosphoprotein 3-like domain superfamily", "go_ids": [], "go_terms": [], "name": "GPP34-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038262": {"description": "Nitrate reductase beta, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Nitr_red_bet_C_sf", "pathway_ids": ["PWY-6748"], "pathways": ["PWY-6748:t:nitrate reduction VII (denitrification)"], "type": "Homologous_superfamily"}, "IPR038263": {"description": "Lytic exoenzyme, target recognition domain superfamily", "go_ids": [], "go_terms": [], "name": "Lytic_exo_TRD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038265": {"description": "PA2222-like domain superfamily", "go_ids": [], "go_terms": [], "name": "PA2222-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038266": {"description": "NapC/NirT cytochrome c superfamily", "go_ids": [], "go_terms": [], "name": "NapC/NirT_cytc_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038267": {"description": "Putative ECF-type sigma factor negative effector", "go_ids": [], "go_terms": [], "name": "ECF_sigma_eff", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038268": {"description": "Ribbon-helix-helix domain superfamily", "go_ids": [], "go_terms": [], "name": "RHH_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038269": {"description": "SCAN domain superfamily", "go_ids": [], "go_terms": [], "name": "SCAN_sf", "pathway_ids": ["R-HSA-9819196", "R-MMU-212436", "R-RNO-212436", "R-HSA-452723", "R-HSA-212436", "R-BTA-212436"], "pathways": ["R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-212436:r:Generic Transcription Pathway", "R-RNO-212436:r:Generic Transcription Pathway", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Homologous_superfamily"}, "IPR038270": {"description": "SopA, catalytic domain superfamily", "go_ids": [], "go_terms": [], "name": "SopA_catalytic_sf", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Homologous_superfamily"}, "IPR038272": {"description": "Bd37, core domain superfamily", "go_ids": [], "go_terms": [], "name": "Bd37_core_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038273": {"description": "Ndc80 domain superfamily", "go_ids": [], "go_terms": [], "name": "Ndc80_sf", "pathway_ids": ["R-MMU-2500257", "R-XTR-9648025", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-DRE-2500257", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-HSA-9648025", "R-XTR-68877", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-GGA-2500257", "R-GGA-141444", "R-XTR-141444", "R-HSA-68877", "R-GGA-9648025", "R-GGA-5663220", "R-HSA-5663220", "R-DRE-5663220", "R-GGA-2467813", "R-MMU-9648025", "R-XTR-2500257", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Homologous_superfamily"}, "IPR038274": {"description": "Atg6/Beclin C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Atg6/Beclin_C_sf", "pathway_ids": ["R-DRE-5689880", "R-HSA-9694676", "R-DDI-1632852", "R-HSA-9705671", "R-BTA-5689880", "R-HSA-5689880", "R-MMU-1632852", "R-CEL-1632852", "R-RNO-1169408", "R-HSA-1169408", "R-MMU-1169408", "R-BTA-1632852", "R-RNO-5689880", "R-CEL-5689880", "R-MMU-5689880", "R-SCE-1632852", "R-HSA-983170", "R-CEL-1169408", "R-RNO-1632852", "R-XTR-1632852", "R-DDI-5689880", "R-HSA-1632852", "R-DME-1632852", "R-HSA-9833110", "R-HSA-9920951", "R-SPO-1632852", "R-BTA-1169408", "R-HSA-9679504", "R-DME-5689880", "R-DDI-1169408"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DDI-1632852:r:Macroautophagy", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-BTA-1632852:r:Macroautophagy", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-1632852:r:Macroautophagy", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SPO-1632852:r:Macroautophagy", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DME-5689880:r:Ub-specific processing proteases", "R-DDI-1169408:r:ISG15 antiviral mechanism"], "type": "Homologous_superfamily"}, "IPR038275": {"description": "Nuf2, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Nuf2_N_sf", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-2500257", "R-DRE-2500257", "R-MMU-2467813", "R-HSA-141444", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-RNO-5663220", "R-HSA-9648025", "R-HSA-68877", "R-RNO-9648025", "R-RNO-2467813", "R-DRE-5663220", "R-HSA-5663220", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Homologous_superfamily"}, "IPR038276": {"description": "Floricaula/leafy, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Floricaula/leafy_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038277": {"description": "UreF domain superfamily", "go_ids": [], "go_terms": [], "name": "UreF_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038279": {"description": "Ndc10, domain 2 superfamily", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Ndc10_dom2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038280": {"description": "Telomere resolvase ResT/TelK, catalytic domain superfamily", "go_ids": [], "go_terms": [], "name": "ResT/TelK_cat_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038281": {"description": "RTP801-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RTP801-like_C_sf", "pathway_ids": ["R-RNO-5628897", "R-HSA-5628897", "R-DME-5628897", "R-XTR-5628897", "R-BTA-5628897", "R-DRE-5628897", "R-MMU-5628897"], "pathways": ["R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Homologous_superfamily"}, "IPR038282": {"description": "DUF2267 superfamily", "go_ids": [], "go_terms": [], "name": "DUF2267_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038283": {"description": "Channel forming colicin, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Channel_colicin_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038286": {"description": "Inositol polyphosphate kinase superfamily", "go_ids": [], "go_terms": [], "name": "IPK_sf", "pathway_ids": ["R-CEL-1855204", "R-HSA-1855167", "R-MMU-1855167", "R-HSA-909733", "R-SPO-1855167", "R-HSA-1855204", "R-RNO-1855204", "R-SPO-1855191", "R-RNO-1855191", "R-MMU-1855191", "R-MMU-1855204", "R-SCE-1855167", "R-HSA-1855191", "R-SCE-1855191", "R-RNO-1855167"], "pathways": ["R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SPO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SPO-1855191:r:Synthesis of IPs in the nucleus", "R-RNO-1855191:r:Synthesis of IPs in the nucleus", "R-MMU-1855191:r:Synthesis of IPs in the nucleus", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-1855191:r:Synthesis of IPs in the nucleus", "R-SCE-1855191:r:Synthesis of IPs in the nucleus", "R-RNO-1855167:r:Synthesis of pyrophosphates in the cytosol"], "type": "Homologous_superfamily"}, "IPR038287": {"description": "Cse2 superfamily", "go_ids": [], "go_terms": [], "name": "Cse2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038288": {"description": "Peptidoglycan hydrolase Gp5 superfamily", "go_ids": [], "go_terms": [], "name": "Gp5_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038289": {"description": "DVA-1 superfamily", "go_ids": [], "go_terms": [], "name": "DVA-1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038291": {"description": "SAP30, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "SAP30_C_sf", "pathway_ids": ["R-XTR-3214815", "R-HSA-427413", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-DRE-3214815", "R-SCE-3214815", "R-DME-3214815"], "pathways": ["R-XTR-3214815:r:HDACs deacetylate histones", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DRE-3214815:r:HDACs deacetylate histones", "R-SCE-3214815:r:HDACs deacetylate histones", "R-DME-3214815:r:HDACs deacetylate histones"], "type": "Homologous_superfamily"}, "IPR038292": {"description": "YmfJ/YflH superfamily", "go_ids": [], "go_terms": [], "name": "YmfJ/YflH_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038293": {"description": "ATPase inhibitor subunit zeta superfamily", "go_ids": [], "go_terms": [], "name": "ATPase_inh_sub_z_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038294": {"description": "SLBP, RNA-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "SLBP_RNA_bind_sf", "pathway_ids": ["R-DME-159230", "R-HSA-159230", "R-CEL-159230", "R-MMU-77588", "R-HSA-77588", "R-MMU-73856", "R-HSA-73856", "R-DME-77588", "R-DME-73856", "R-CEL-73856", "R-CEL-77588", "R-MMU-159230"], "pathways": ["R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-HSA-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-77588:r:SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA"], "type": "Homologous_superfamily"}, "IPR038295": {"description": "STAT1, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "STAT1_C_sf", "pathway_ids": ["R-MMU-8985947", "R-HSA-9705671", "R-HSA-9942503", "R-HSA-1059683", "R-HSA-9833482", "R-HSA-9020958", "R-HSA-9680350", "R-MMU-9020956", "R-HSA-1169408", "R-HSA-9670439", "R-MMU-9020958", "R-MMU-9833482", "R-HSA-9673770", "R-HSA-9725370", "R-HSA-877312", "R-HSA-2173795", "R-HSA-912694", "R-HSA-9673767", "R-MMU-909733", "R-MMU-186763", "R-MMU-877312", "R-HSA-8984722", "R-MMU-6785807", "R-MMU-8854691", "R-HSA-9013508", "R-MMU-1433557", "R-MMU-8984722", "R-HSA-1433557", "R-HSA-6785807", "R-MMU-1169408", "R-HSA-8854691", "R-MMU-877300", "R-HSA-982772", "R-HSA-186763", "R-HSA-8939902", "R-MMU-1059683", "R-HSA-9909649", "R-HSA-909733", "R-HSA-9705462", "R-HSA-877300", "R-MMU-912694", "R-HSA-9860927", "R-HSA-9674555", "R-HSA-8985947", "R-HSA-9020956", "R-MMU-9860927", "R-HSA-1839117"], "pathways": ["R-MMU-8985947:r:Interleukin-9 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-MMU-877300:r:Interferon gamma signaling", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-1059683:r:Interleukin-6 signaling", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-8985947:r:Interleukin-9 signaling", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Homologous_superfamily"}, "IPR038296": {"description": "Antitoxin ParD superfamily", "go_ids": [], "go_terms": [], "name": "ParD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038297": {"description": "CcmH/CycL/Ccl2/NrfF domain superfamily", "go_ids": [], "go_terms": [], "name": "CcmH/CycL/NrfF/Ccl2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038298": {"description": "Daxx, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Daxx_N_sf", "pathway_ids": ["R-RNO-6804757", "R-MMU-3899300", "R-CFA-9670095", "R-HSA-6804757", "R-HSA-9670095", "R-CFA-6804757", "R-MMU-6804757", "R-HSA-9670613", "R-HSA-9670615", "R-HSA-9920951", "R-HSA-3899300", "R-HSA-9609690", "R-RNO-3899300", "R-MMU-9670095"], "pathways": ["R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-CFA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-9670613:r:Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations", "R-HSA-9670615:r:Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere"], "type": "Homologous_superfamily"}, "IPR038299": {"description": "Alpha-glycerophosphate oxidase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DAO_C_sf", "pathway_ids": ["PWY-6118", "PWY-4261", "PWY-6952", "R-RNO-163560", "R-MMU-1483166", "R-DDI-163560", "R-CEL-163560", "R-SPO-1483166", "R-RNO-1483166", "R-SCE-163560", "R-DDI-1483166", "R-BTA-1483166", "R-MMU-163560", "R-HSA-1483166", "R-SPO-163560", "R-CEL-1483166", "R-BTA-163560", "R-SCE-1483166", "R-HSA-163560"], "pathways": ["PWY-6118:t:glycerol-3-phosphate shuttle", "PWY-4261:t:glycerol degradation I", "PWY-6952:t:glycerophosphodiester degradation", "R-RNO-163560:r:Triglyceride catabolism", "R-MMU-1483166:r:Synthesis of PA", "R-DDI-163560:r:Triglyceride catabolism", "R-CEL-163560:r:Triglyceride catabolism", "R-SPO-1483166:r:Synthesis of PA", "R-RNO-1483166:r:Synthesis of PA", "R-SCE-163560:r:Triglyceride catabolism", "R-DDI-1483166:r:Synthesis of PA", "R-BTA-1483166:r:Synthesis of PA", "R-MMU-163560:r:Triglyceride catabolism", "R-HSA-1483166:r:Synthesis of PA", "R-SPO-163560:r:Triglyceride catabolism", "R-CEL-1483166:r:Synthesis of PA", "R-BTA-163560:r:Triglyceride catabolism", "R-SCE-1483166:r:Synthesis of PA", "R-HSA-163560:r:Triglyceride catabolism"], "type": "Homologous_superfamily"}, "IPR038300": {"description": "SASP, alpha/beta-type superfamily", "go_ids": [], "go_terms": [], "name": "SASP_sf_alpha/beta", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038301": {"description": "AraC-like superfamily", "go_ids": [], "go_terms": [], "name": "AraC-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038302": {"description": "Envelope glycoprotein M superfamily, flavivirus", "go_ids": [], "go_terms": [], "name": "Env_glycoprot_M_sf_flavivir", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Homologous_superfamily"}, "IPR038303": {"description": "HNS-dependent expression A/B superfamily", "go_ids": [], "go_terms": [], "name": "HdeA/HdeB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038304": {"description": "YmgD domain superfamily", "go_ids": [], "go_terms": [], "name": "YmgD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038305": {"description": "HeLo domain superfamily", "go_ids": [], "go_terms": [], "name": "HeLo_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038306": {"description": "CagS superfamily", "go_ids": [], "go_terms": [], "name": "CagS_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038307": {"description": "StbB superfamily", "go_ids": [], "go_terms": [], "name": "StbB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038308": {"description": "RFXAP, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RFXAP_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038309": {"description": "Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ superfamily", "go_ids": [], "go_terms": [], "name": "Rsd/AlgQ_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038310": {"description": "DUF1104 superfamily", "go_ids": [], "go_terms": [], "name": "DUF1104_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038311": {"description": "Herpesvirus glycoprotein L, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Herpes_gL_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038312": {"description": "DUF5063 superfamily", "go_ids": [], "go_terms": [], "name": "DUF5063_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038313": {"description": "Herpesvirus glycoprotein L, rhadinovirus-type superfamily", "go_ids": [], "go_terms": [], "name": "Herpes_gL_rhadinovirus_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038314": {"description": "T6SS superfamily", "go_ids": [], "go_terms": [], "name": "T6SS_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038315": {"description": "FLiS export co-chaperone, HP1076 superfamily", "go_ids": [], "go_terms": [], "name": "FliS_cochap_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038316": {"description": "DUF5062 superfamily", "go_ids": [], "go_terms": [], "name": "DUF5062_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038317": {"description": "Pf1176-like superfamily", "go_ids": [], "go_terms": [], "name": "Pf1176-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038318": {"description": "KdpD, transmembrane domain superfamily", "go_ids": [], "go_terms": [], "name": "KdpD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038319": {"description": "CAS, serine rich four helix bundle domain superfamily", "go_ids": [], "go_terms": [], "name": "Serine_rich_sf", "pathway_ids": ["R-MMU-372708", "R-RNO-186763", "R-RNO-8849471", "R-HSA-186763", "R-RNO-372708", "R-HSA-372708", "R-MMU-4420097", "R-MMU-8849471", "R-MMU-186763", "R-RNO-4420097", "R-HSA-8849471", "R-HSA-4420097"], "pathways": ["R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-186763:r:Downstream signal transduction", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-186763:r:Downstream signal transduction", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Homologous_superfamily"}, "IPR038320": {"description": "KinB, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "KinB_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038321": {"description": "TmcA, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "TmcA_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038322": {"description": "Pex19, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Pex19_C_sf", "pathway_ids": ["R-DDI-1369062", "R-SCE-9603798", "R-BTA-1369062", "R-SCE-1369062", "R-BTA-9603798", "R-SPO-9603798", "R-RNO-9603798", "R-CEL-9603798", "R-CEL-1369062", "R-DDI-9603798", "R-MMU-1369062", "R-MMU-9603798", "R-RNO-1369062", "R-HSA-9603798", "R-HSA-9918481", "R-HSA-1369062"], "pathways": ["R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-BTA-1369062:r:ABC transporters in lipid homeostasis", "R-SCE-1369062:r:ABC transporters in lipid homeostasis", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-1369062:r:ABC transporters in lipid homeostasis"], "type": "Homologous_superfamily"}, "IPR038323": {"description": "Putative aromatic acid exporter, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ArAE_1_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038324": {"description": "Rpb4/RPC9 superfamily", "go_ids": [], "go_terms": [], "name": "Rpb4/RPC9_sf", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-MMU-9770562", "R-HSA-73980", "R-DDI-73776", "R-DME-72163", "R-BTA-76071", "R-SPO-6781823", "R-DDI-6782210", "R-DDI-72163", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-BTA-76066", "R-BTA-9018519", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-BTA-77075", "R-DME-72203", "R-DDI-674695", "R-DME-72086", "R-MMU-76061", "R-HSA-76061", "R-SPO-6796648", "R-DME-75953", "R-HSA-749476", "R-DME-6782135", "R-SCE-76061", "R-BTA-72163", "R-BTA-75955", "R-BTA-75953", "R-SPO-9018519", "R-BTA-6782135", "R-MMU-72163", "R-SPO-76066", "R-HSA-6803529", "R-HSA-167242", "R-HSA-8851708", "R-HSA-167161", "R-HSA-72163", "R-DME-112382", "R-RNO-76061", "R-HSA-9670095", "R-HSA-167160", "R-DDI-77075", "R-SPO-73779", "R-BTA-6782210", "R-DDI-113418", "R-MMU-72086", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-DME-5578749", "R-DME-77075", "R-DME-73779", "R-BTA-5578749", "R-DME-9770562", "R-DME-73776", "R-BTA-6781823", "R-MMU-6781823", "R-HSA-203927", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-HSA-72165", "R-HSA-73780", "R-DDI-76042", "R-MMU-73776", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-HSA-76071", "R-DME-113418", "R-HSA-72203", "R-MMU-6796648", "R-RNO-76071", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-SCE-6781823", "R-MMU-76071", "R-BTA-674695", "R-RNO-76066", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-167290", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-BTA-6807505", "R-BTA-72203", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-BTA-76042", "R-SPO-6807505", "R-MMU-76066", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-BTA-76061", "R-HSA-167246", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-HSA-9018519", "R-MMU-76042", "R-HSA-5601884", "R-SPO-75953", "R-SPO-113418", "R-DDI-73779", "R-DME-674695", "R-BTA-72086", "R-DME-9018519", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-MMU-674695", "R-MMU-6807505", 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Promoter", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", 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expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER"], "type": "Homologous_superfamily"}, "IPR038325": {"description": "Interleukin-7 superfamily", "go_ids": [], "go_terms": [], "name": "IL7_sf", "pathway_ids": ["R-BTA-1266695", "R-SSC-1266695", "R-RNO-1266695", "R-MMU-1266695", "R-HSA-1266695"], "pathways": ["R-BTA-1266695:r:Interleukin-7 signaling", "R-SSC-1266695:r:Interleukin-7 signaling", "R-RNO-1266695:r:Interleukin-7 signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-1266695:r:Interleukin-7 signaling"], "type": "Homologous_superfamily"}, "IPR038326": {"description": "Interferon lambda superfamily", "go_ids": [], "go_terms": [], "name": "IFN-lambda_sf", "pathway_ids": ["R-MMU-8854691", "R-HSA-449836", "R-GGA-449836", "R-HSA-8854691", "R-GGA-8854691"], "pathways": ["R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-449836:r:Other interleukin signaling", "R-GGA-449836:r:Other interleukin signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-GGA-8854691:r:Interleukin-20 family signaling"], "type": "Homologous_superfamily"}, "IPR038328": {"description": "Interleukin-34 superfamily", "go_ids": [], "go_terms": [], "name": "IL-34_sf", "pathway_ids": ["R-HSA-449836", "R-BTA-449836", "R-RNO-449836", "R-HSA-9680350", "R-MMU-449836"], "pathways": ["R-HSA-449836:r:Other interleukin signaling", "R-BTA-449836:r:Other interleukin signaling", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-449836:r:Other interleukin signaling"], "type": "Homologous_superfamily"}, "IPR038329": {"description": "Thymic stromal lymphopoietin superfamily", "go_ids": [], "go_terms": [], "name": "TSLP_sf", "pathway_ids": ["R-MMU-1266695", "R-HSA-1266695"], "pathways": ["R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-1266695:r:Interleukin-7 signaling"], "type": "Homologous_superfamily"}, "IPR038330": {"description": "TspO/MBR-related superfamily", "go_ids": [], "go_terms": [], "name": "TspO/MBR-related_sf", "pathway_ids": ["R-MMU-196108", "R-HSA-196108", "R-RNO-196108"], "pathways": ["R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-RNO-196108:r:Pregnenolone biosynthesis"], "type": "Homologous_superfamily"}, "IPR038331": {"description": "DisA, linker domain superfamily", "go_ids": [], "go_terms": [], "name": "DisA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038332": {"description": "PPE superfamily", "go_ids": [], "go_terms": [], "name": "PPE_sf", "pathway_ids": ["R-HSA-9636249"], "pathways": ["R-HSA-9636249:r:Inhibition of nitric oxide production"], "type": "Homologous_superfamily"}, "IPR038333": {"description": "Type I restriction enzyme EcoKI-like, methylase subunit, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "T1MK-like_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038334": {"description": "NleF superfamily", "go_ids": [], "go_terms": [], "name": "NleF_sf", "pathway_ids": ["R-HSA-9956593"], "pathways": ["R-HSA-9956593:r:Enterobacterial factors antagonize host defense"], "type": "Homologous_superfamily"}, "IPR038335": {"description": "ACP, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ACP_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038336": {"description": "NET domain superfamily", "go_ids": [], "go_terms": [], "name": "NET_sf", "pathway_ids": ["R-HSA-9909649", "R-HSA-9679191", "R-DME-8951936", "R-DME-9909649", "R-HSA-8951936"], "pathways": ["R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-8951936:r:RUNX3 regulates p14-ARF", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-8951936:r:RUNX3 regulates p14-ARF"], "type": "Homologous_superfamily"}, "IPR038337": {"description": "Poxvirus poly(A) polymerase, catalytic subunit, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Poxvirus_polyA_pol_cat_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038338": {"description": "PriC superfamily", "go_ids": [], "go_terms": [], "name": "PriC_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038339": {"description": "MatP, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MatP_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038340": {"description": "MRP-L47 superfamily, mitochondrial", "go_ids": [], "go_terms": [], "name": "MRP-L47_sf", "pathway_ids": ["R-MMU-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-MMU-5389840", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Homologous_superfamily"}, "IPR038341": {"description": "UvsW.1-like superfamily", "go_ids": [], "go_terms": [], "name": "UvsW.1-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038342": {"description": "Effector protein HopAB, BAK1-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "HopAB_BAK-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038343": {"description": "DUF4951 superfamily", "go_ids": [], "go_terms": [], "name": "DUF4951_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038344": {"description": "EF-G binding protein, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "EF-G_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038345": {"description": "Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily", "go_ids": [], "go_terms": [], "name": "Flavi_E_Stem/Anchor_dom_sf", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Homologous_superfamily"}, "IPR038346": {"description": "DrrA, PI4P binding domain superfamily", "go_ids": [], "go_terms": [], "name": "DrrA_PI4P-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038347": {"description": "TyeA superfamily", "go_ids": [], "go_terms": [], "name": "TyeA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038348": {"description": "SLED domain superfamily", "go_ids": [], "go_terms": [], "name": "SLED_sf", "pathway_ids": ["R-HSA-4655427", "R-DME-8939243", "R-HSA-3108214", "R-MMU-3899300", "R-HSA-2559580", "R-MMU-4570464", "R-MMU-8939243", "R-DME-3108214", "R-MMU-8943724", "R-DME-2559580", "R-MMU-4551638", "R-HSA-8939243", "R-DME-4570464", "R-HSA-8943724", "R-DME-3899300", "R-HSA-4570464", "R-MMU-3108214", "R-HSA-3899300", "R-HSA-4551638", "R-DME-8943724"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-8943724:r:Regulation of PTEN gene transcription"], "type": "Homologous_superfamily"}, "IPR038349": {"description": "Surface antigen, GAG-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "GAG_BD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038350": {"description": "Orai superfamily", "go_ids": [], "go_terms": [], "name": "Orai_sf", "pathway_ids": ["R-HSA-983695", "R-HSA-5578775", "R-HSA-139853"], "pathways": ["R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5578775:r:Ion homeostasis", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels"], "type": "Homologous_superfamily"}, "IPR038351": {"description": "Malonyl-CoA decarboxylase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MCD_N_sf", "pathway_ids": ["PWY-7485", "PWY-8358", "R-RNO-390247", "R-RNO-9033241", "R-MMU-9033241", "R-HSA-9033241", "R-HSA-390247", "R-MMU-390247"], "pathways": ["PWY-7485:t:tetracenomycin C biosynthesis", "PWY-8358:t:curacin A biosynthesis", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Homologous_superfamily"}, "IPR038352": {"description": "Imelysin-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Imelysin_sf", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Homologous_superfamily"}, "IPR038353": {"description": "Decorin-binding superfamily", "go_ids": [], "go_terms": [], "name": "Decorin-db_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038354": {"description": "VKOR domain superfamily", "go_ids": [], "go_terms": [], "name": "VKOR_sf", "pathway_ids": ["PWY-7999", "R-MMU-6806664", "R-BTA-6806664", "R-HSA-6806664", "R-RNO-6806664"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "R-MMU-6806664:r:Metabolism of vitamin K", "R-BTA-6806664:r:Metabolism of vitamin K", "R-HSA-6806664:r:Metabolism of vitamin K", "R-RNO-6806664:r:Metabolism of vitamin K"], "type": "Homologous_superfamily"}, "IPR038355": {"description": "Tumor necrosis factor alpha-induced protein 8-like superfamily", "go_ids": [], "go_terms": [], "name": "TNFAIP8_sf", "pathway_ids": ["R-DME-1483255", "R-XTR-1483255", "R-BTA-1483255", "R-DRE-1483255", "R-RNO-1483255", "R-MMU-1483255", "R-GGA-1483255", "R-HSA-1483255"], "pathways": ["R-DME-1483255:r:PI Metabolism", "R-XTR-1483255:r:PI Metabolism", "R-BTA-1483255:r:PI Metabolism", "R-DRE-1483255:r:PI Metabolism", "R-RNO-1483255:r:PI Metabolism", "R-MMU-1483255:r:PI Metabolism", "R-GGA-1483255:r:PI Metabolism", "R-HSA-1483255:r:PI Metabolism"], "type": "Homologous_superfamily"}, "IPR038356": {"description": "Tma16 superfamily", "go_ids": [], "go_terms": [], "name": "Tma16_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038357": {"description": "KEN domain superfamily", "go_ids": [], "go_terms": [], "name": "KEN_sf", "pathway_ids": ["R-DDI-381070", "R-HSA-381070", "R-HSA-8983711", "R-HSA-909733", "R-SCE-381070", "R-MMU-909733", "R-MMU-381070", "R-CEL-381070", "R-SPO-381070", "R-MMU-8983711"], "pathways": ["R-DDI-381070:r:IRE1alpha activates chaperones", "R-HSA-381070:r:IRE1alpha activates chaperones", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SCE-381070:r:IRE1alpha activates chaperones", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-381070:r:IRE1alpha activates chaperones", "R-CEL-381070:r:IRE1alpha activates chaperones", "R-SPO-381070:r:IRE1alpha activates chaperones", "R-MMU-8983711:r:OAS antiviral response"], "type": "Homologous_superfamily"}, "IPR038358": {"description": "VPS28, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "VPS28_N_sf", "pathway_ids": ["R-RNO-917729", "R-CEL-917729", "R-HSA-9610379", "R-HSA-917729", "R-MMU-917729", "R-HSA-174490", "R-HSA-9615710", "R-DDI-917729", "R-BTA-917729", "R-HSA-162588", "R-DME-917729"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-9615710:r:Late endosomal microautophagy", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Homologous_superfamily"}, "IPR038359": {"description": "Connexin, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Connexin_N_sf", "pathway_ids": ["R-RNO-190840", "R-HSA-9013409", "R-DRE-196025", "R-MMU-190872", "R-BTA-196025", "R-HSA-9725554", "R-HSA-190861", "R-GGA-190861", "R-HSA-190840", "R-HSA-190873", "R-HSA-191650", "R-BTA-9013406", "R-HSA-9856532", "R-RNO-191650", "R-MMU-191650", "R-DRE-191650", "R-BTA-190704", "R-BTA-190873", "R-BTA-190861", "R-DRE-9013406", "R-BTA-191650", "R-MMU-190873", "R-RNO-196025", "R-RNO-190873", "R-XTR-190861", "R-BTA-190872", "R-HSA-112303", "R-RNO-9013406", "R-HSA-9705677", "R-BTA-112303", "R-HSA-190704", "R-RNO-190704", "R-HSA-190827", "R-RNO-112303", "R-SSC-190861", "R-HSA-196025", "R-BTA-190840", "R-MMU-190840", "R-RNO-190861", "R-MMU-196025", "R-GGA-112303", "R-DRE-190861", "R-GGA-190872", "R-MMU-9013406", "R-HSA-190872", "R-CFA-190861", "R-HSA-9013406", "R-SSC-112303", "R-RNO-190872", "R-MMU-190704", "R-DRE-190840", "R-MMU-112303", "R-MMU-190861"], "pathways": ["R-RNO-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-DRE-196025:r:Formation of annular gap junctions", "R-MMU-190872:r:Transport of connexons to the plasma membrane", "R-BTA-196025:r:Formation of annular gap junctions", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-190861:r:Gap junction assembly", "R-GGA-190861:r:Gap junction assembly", "R-HSA-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-HSA-190873:r:Gap junction degradation", "R-HSA-191650:r:Regulation of gap junction activity", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-RNO-191650:r:Regulation of gap junction activity", "R-MMU-191650:r:Regulation of gap junction activity", "R-DRE-191650:r:Regulation of gap junction activity", "R-BTA-190704:r:Oligomerization of connexins into connexons", "R-BTA-190873:r:Gap junction degradation", "R-BTA-190861:r:Gap junction assembly", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-BTA-191650:r:Regulation of gap junction activity", "R-MMU-190873:r:Gap junction degradation", "R-RNO-196025:r:Formation of annular gap junctions", "R-RNO-190873:r:Gap junction degradation", "R-XTR-190861:r:Gap junction assembly", "R-BTA-190872:r:Transport of connexons to the plasma membrane", "R-HSA-112303:r:Electric Transmission Across Gap Junctions", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-BTA-112303:r:Electric Transmission Across Gap Junctions", "R-HSA-190704:r:Oligomerization of connexins into connexons", "R-RNO-190704:r:Oligomerization of connexins into connexons", "R-HSA-190827:r:Transport of connexins along the secretory pathway", "R-RNO-112303:r:Electric Transmission Across Gap Junctions", "R-SSC-190861:r:Gap junction assembly", "R-HSA-196025:r:Formation of annular gap junctions", "R-BTA-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-MMU-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-RNO-190861:r:Gap junction assembly", "R-MMU-196025:r:Formation of annular gap junctions", "R-GGA-112303:r:Electric Transmission Across Gap Junctions", "R-DRE-190861:r:Gap junction assembly", "R-GGA-190872:r:Transport of connexons to the plasma membrane", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-190872:r:Transport of connexons to the plasma membrane", "R-CFA-190861:r:Gap junction assembly", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-SSC-112303:r:Electric Transmission Across Gap Junctions", "R-RNO-190872:r:Transport of connexons to the plasma membrane", "R-MMU-190704:r:Oligomerization of connexins into connexons", "R-DRE-190840:r:Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "R-MMU-112303:r:Electric Transmission Across Gap Junctions", "R-MMU-190861:r:Gap junction assembly"], "type": "Homologous_superfamily"}, "IPR038360": {"description": "DUF4844 superfamily", "go_ids": [], "go_terms": [], "name": "DUF4844_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038361": {"description": "2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, middle domain superfamily", "go_ids": [], "go_terms": [], "name": "THDPS_M_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038362": {"description": "VP9, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "VP9_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038363": {"description": "LepA, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "LepA_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038364": {"description": "Urocanase, central domain superfamily", "go_ids": [], "go_terms": [], "name": "Urocanase_central_sf", "pathway_ids": ["PWY-5030", "PWY-5028", "R-MMU-70921", "R-CEL-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5028:t:L-histidine degradation II", "R-MMU-70921:r:Histidine catabolism", "R-CEL-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Homologous_superfamily"}, "IPR038365": {"description": "EcoRII, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "EcoRII_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038366": {"description": "Zinc finger, ClpX C4-type superfamily", "go_ids": [], "go_terms": [], "name": "Znf_CppX_C4_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038367": {"description": "PelD, GGDEF domain superfamily", "go_ids": [], "go_terms": [], "name": "PelD_GGDEF_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038368": {"description": "Mastadenovirus E4/Orf3 superfamily", "go_ids": [], "go_terms": [], "name": "Mastadenovirus_E4/Orf3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038369": {"description": "Stage V sporulation AD superfamily", "go_ids": [], "go_terms": [], "name": "SpoVAD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038370": {"description": "ArcTGT, C1 domain superfamily", "go_ids": [], "go_terms": [], "name": "ArcTGT_C1_sf", "pathway_ids": ["PWY-6711", "PWY-7923"], "pathways": ["PWY-6711:t:archaeosine biosynthesis I", "PWY-7923:t:archaeosine biosynthesis II"], "type": "Homologous_superfamily"}, "IPR038371": {"description": "Multi-copper polyphenol oxidoreductase superfamily", "go_ids": [], "go_terms": [], "name": "Cu_polyphenol_OxRdtase_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038372": {"description": "Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain", "go_ids": [], "go_terms": [], "name": "PA/PA-X_sf", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-192814", "R-HSA-192905", "R-HSA-168275", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Homologous_superfamily"}, "IPR038373": {"description": "Restriction endonuclease, type II, HindIII superfamily", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_HindIII_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038374": {"description": "Type II restriction endonuclease subunit R superfamily", "go_ids": [], "go_terms": [], "name": "ThaI_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038375": {"description": "Protein arginine methyltransferase NDUFAF7 superfamily", "go_ids": [], "go_terms": [], "name": "NDUFAF7_sf", "pathway_ids": ["R-DME-6799198", "R-MMU-6799198", "R-CEL-6799198", "R-HSA-6799198", "R-DDI-6799198", "R-RNO-6799198", "R-DRE-6799198", "R-XTR-6799198"], "pathways": ["R-DME-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-CEL-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-6799198:r:Complex I biogenesis", "R-XTR-6799198:r:Complex I biogenesis"], "type": "Homologous_superfamily"}, "IPR038376": {"description": "ATP synthase, alpha subunit, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ATP_synth_asu_C_sf", "pathway_ids": ["PWY-7980", "R-DDI-9837999", "R-MMU-9837999", "R-CEL-9837999", "R-SSC-8949613", "R-DME-9837999", "R-MMU-163210", "R-CEL-163210", "R-DME-163210", "R-CEL-8949613", "R-RNO-9837999", "R-HSA-8949613", "R-DME-8949613", "R-HSA-163210", "R-HSA-1268020", "R-SPO-9837999", "R-SCE-9837999", "R-SSC-9837999", "R-HSA-9837999", "R-RNO-163210", "R-RNO-8949613", "R-MMU-8949613", "R-SSC-163210"], "pathways": ["PWY-7980:t:ATP biosynthesis", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-SSC-8949613:r:Cristae formation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-8949613:r:Cristae formation", "R-DME-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-SSC-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Homologous_superfamily"}, "IPR038377": {"description": "Sodium/glucose symporter superfamily", "go_ids": [], "go_terms": [], "name": "Na/Glc_symporter_sf", "pathway_ids": ["R-MMU-196807", "R-MMU-9958517", "R-DRE-196807", "R-CEL-9958517", "R-HSA-5656364", "R-RNO-9958517", "R-SSC-8981373", "R-DME-9958517", "R-MMU-429593", "R-HSA-196780", "R-HSA-199220", "R-BTA-428643", "R-CFA-429593", "R-HSA-428643", "R-MMU-199220", "R-RNO-199220", "R-DME-264642", "R-HSA-425397", "R-HSA-209968", "R-RNO-8981373", "R-MMU-189200", "R-RNO-189200", "R-RNO-196780", "R-XTR-428643", "R-DRE-189200", "R-DRE-428643", "R-CEL-264642", "R-MMU-8981373", "R-HSA-5619114", "R-DRE-9958790", "R-MMU-428643", "R-RNO-209968", "R-HSA-5658208", "R-XTR-9958790", "R-HSA-9958790", "R-MMU-9958790", "R-HSA-196807", "R-HSA-264642", "R-HSA-8981373", "R-HSA-189200", "R-BTA-189200", "R-SSC-189200", "R-MMU-196780", "R-MMU-425397", "R-RNO-429593", "R-MMU-264642", "R-HSA-9958517", "R-XTR-196807", "R-RNO-264642", "R-RNO-425397", "R-MMU-209968", "R-HSA-5658471", "R-RNO-9958790", "R-HSA-429593", "R-HSA-5619096"], "pathways": ["R-MMU-196807:r:Nicotinate metabolism", "R-MMU-9958517:r:SLC-mediated bile acid transport", "R-DRE-196807:r:Nicotinate metabolism", "R-CEL-9958517:r:SLC-mediated bile acid transport", "R-HSA-5656364:r:Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)", "R-RNO-9958517:r:SLC-mediated bile acid transport", "R-SSC-8981373:r:Intestinal hexose absorption", "R-DME-9958517:r:SLC-mediated bile acid transport", "R-MMU-429593:r:Inositol transporters", "R-HSA-196780:r:Biotin transport and metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-BTA-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-CFA-429593:r:Inositol transporters", "R-HSA-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-HSA-209968:r:Thyroxine biosynthesis", "R-RNO-8981373:r:Intestinal hexose absorption", "R-MMU-189200:r:Cellular hexose transport", "R-RNO-189200:r:Cellular hexose transport", "R-RNO-196780:r:Biotin transport and metabolism", "R-XTR-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-DRE-189200:r:Cellular hexose transport", "R-DRE-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-8981373:r:Intestinal hexose absorption", "R-HSA-5619114:r:Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "R-DRE-9958790:r:SLC-mediated transport of inorganic anions", "R-MMU-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-RNO-209968:r:Thyroxine biosynthesis", "R-HSA-5658208:r:Defective SLC5A2 causes renal glucosuria (GLYS1)", "R-XTR-9958790:r:SLC-mediated transport of inorganic anions", "R-HSA-9958790:r:SLC-mediated transport of inorganic anions", "R-MMU-9958790:r:SLC-mediated transport of inorganic anions", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-8981373:r:Intestinal hexose absorption", "R-HSA-189200:r:Cellular hexose transport", "R-BTA-189200:r:Cellular hexose transport", "R-SSC-189200:r:Cellular hexose transport", "R-MMU-196780:r:Biotin transport and metabolism", "R-MMU-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-RNO-429593:r:Inositol transporters", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-9958517:r:SLC-mediated bile acid transport", "R-XTR-196807:r:Nicotinate metabolism", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-425397:r:Transport of vitamins, nucleosides, and related molecules", "R-MMU-209968:r:Thyroxine biosynthesis", "R-HSA-5658471:r:Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "R-RNO-9958790:r:SLC-mediated transport of inorganic anions", "R-HSA-429593:r:Inositol transporters", "R-HSA-5619096:r:Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)"], "type": "Homologous_superfamily"}, "IPR038378": {"description": "Haemophore, haem-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "MHB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038379": {"description": "SecE superfamily", "go_ids": [], "go_terms": [], "name": "SecE_sf", "pathway_ids": ["R-HSA-9760173", "R-HSA-1222387"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Homologous_superfamily"}, "IPR038380": {"description": "Small ribosomal subunit protein bS21 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_bS21_sf", "pathway_ids": ["R-BTA-5389840", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-HSA-5419276", "R-BTA-9937383", "R-HSA-5368286"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Homologous_superfamily"}, "IPR038381": {"description": "DNA replication regulator HobA superfamily", "go_ids": [], "go_terms": [], "name": "HobA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038382": {"description": "Ste5, Fus3-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Ste5_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038383": {"description": "CGT/MARTX, cysteine protease (CPD) domain superfamily", "go_ids": [], "go_terms": [], "name": "CPD_dom_sf", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Homologous_superfamily"}, "IPR038384": {"description": "Formate dehydrogenase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Formate_DH_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038385": {"description": "Threonylcarbamoyl-AMP synthase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Sua5/YwlC_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038386": {"description": "Beta-thymosin superfamily", "go_ids": [], "go_terms": [], "name": "Beta-thymosin_sf", "pathway_ids": ["R-HSA-114608", "R-RNO-114608", "R-MMU-114608", "R-SSC-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation", "R-SSC-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR038387": {"description": "Bacteriochlorophyll c-binding superfamily", "go_ids": [], "go_terms": [], "name": "Bchl_C-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038388": {"description": "RcsC, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RcsC_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038389": {"description": "Proteasome assembly chaperone 2 superfamily", "go_ids": [], "go_terms": [], "name": "PSMG2_sf", "pathway_ids": ["R-SCE-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-DRE-9907900", "R-BTA-9907900", "R-DDI-9907900"], "pathways": ["R-SCE-9907900:r:Proteasome assembly", "R-HSA-9907900:r:Proteasome assembly", "R-MMU-9907900:r:Proteasome assembly", "R-DRE-9907900:r:Proteasome assembly", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-9907900:r:Proteasome assembly"], "type": "Homologous_superfamily"}, "IPR038390": {"description": "Metal-sensitive repressor, helix protomer superfamily", "go_ids": [], "go_terms": [], "name": "Metal_Tscrpt_repr_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038391": {"description": "L-fucose isomerase, domain 1 superfamily", "go_ids": [], "go_terms": [], "name": "Fucose_iso_dom1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038392": {"description": "L-fucose isomerase, domain 2 superfamily", "go_ids": [], "go_terms": [], "name": "Fucose_isomerase_dom2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038393": {"description": "L-fucose isomerase, domain 3 superfamily", "go_ids": [], "go_terms": [], "name": "Fuc_iso_dom3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038394": {"description": "TA0956 superfamily", "go_ids": [], "go_terms": [], "name": "TA0956_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038396": {"description": "SpoIIAA-like superfamily", "go_ids": [], "go_terms": [], "name": "SpoIIAA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038397": {"description": "TBCC, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "TBCC_N_sf", "pathway_ids": ["R-HSA-389977"], "pathways": ["R-HSA-389977:r:Post-chaperonin tubulin folding pathway"], "type": "Homologous_superfamily"}, "IPR038398": {"description": "NAB co-repressor domain 2 superfamily", "go_ids": [], "go_terms": [], "name": "NCD2_sf", "pathway_ids": ["R-HSA-9619665", "R-DME-9031628", "R-HSA-9031628", "R-CEL-9031628", "R-MMU-9031628"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-9031628:r:NGF-stimulated transcription", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-MMU-9031628:r:NGF-stimulated transcription"], "type": "Homologous_superfamily"}, "IPR038400": {"description": "Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirus", "go_ids": [], "go_terms": [], "name": "NSP3_SUD-M_sf_bCoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR038401": {"description": "Rev1, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Rev1_C_sf", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706", "R-MMU-5655862", "R-GGA-5656121", "R-SPO-5656169", "R-SPO-5656121", "R-SPO-5655862", "R-MMU-5656169", "R-HSA-5656169", "R-MMU-110312", "R-SPO-110312", "R-DME-5656121", "R-HSA-110312", "R-GGA-5655862", "R-HSA-5655862", "R-GGA-353503", "R-GGA-110312", "R-GGA-5656169", "R-MMU-5656121", "R-DME-5655862", "R-DME-110312", "R-HSA-5656121"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-DME-5656121:r:Translesion synthesis by POLI", "R-HSA-110312:r:Translesion synthesis by REV1", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-GGA-353503:r:Translesion synthesis by Pol kappa", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-5656121:r:Translesion synthesis by POLI"], "type": "Homologous_superfamily"}, "IPR038402": {"description": "Restriction endonuclease, type II, PvuII superfamily", "go_ids": [], "go_terms": [], "name": "PvuII_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038403": {"description": "Plasmodium falciparum UIS3, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PfUIS3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038404": {"description": "TRAP transporter solute receptor DctP superfamily", "go_ids": [], "go_terms": [], "name": "TRAP_DctP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038405": {"description": "Cytochrome oxidase Caa3-type, subunit IV superfamily", "go_ids": [], "go_terms": [], "name": "Caa3-IV_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038406": {"description": "DUF3837 superfamily", "go_ids": [], "go_terms": [], "name": "DUF3837_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038407": {"description": "Vesicle transport v-SNARE, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "v-SNARE_N_sf", "pathway_ids": ["R-HSA-381038", "R-SCE-6811440", "R-RNO-5694530", "R-HSA-6811438", "R-MMU-6811438", "R-RNO-6811440", "R-RNO-6807878", "R-RNO-6811438", "R-HSA-6807878", "R-SCE-114608", "R-SPO-6811440", "R-DDI-114608", "R-HSA-6811440", "R-DME-6811438", "R-HSA-5694530", "R-RNO-204005", "R-RNO-114608", "R-SPO-114608", "R-MMU-6811440", "R-HSA-204005", "R-DDI-6811438", "R-HSA-114608", "R-DDI-6811440", "R-DME-6807878", "R-DME-5694530", "R-MMU-114608", "R-DME-204005"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SCE-114608:r:Platelet degranulation", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-114608:r:Platelet degranulation", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-RNO-114608:r:Platelet degranulation", "R-SPO-114608:r:Platelet degranulation", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-DDI-6811438:r:Intra-Golgi traffic", "R-HSA-114608:r:Platelet degranulation", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-DME-5694530:r:Cargo concentration in the ER", "R-MMU-114608:r:Platelet degranulation", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Homologous_superfamily"}, "IPR038408": {"description": "Gnk2-homologous domain superfamily", "go_ids": [], "go_terms": [], "name": "GNK2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038409": {"description": "Ycf54-like superfamily", "go_ids": [], "go_terms": [], "name": "Ycf54-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038410": {"description": "GxGYxYP putative glycoside hydrolase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "GxGYxYP_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038411": {"description": "PurL, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PurL_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038412": {"description": "Pepsin inhibitor-3 domain superfamily", "go_ids": [], "go_terms": [], "name": "Pepsin-I3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038413": {"description": "FTO, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "FTO_C_sf", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-HSA-73943", "R-RNO-73943", "R-MMU-73943"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-HSA-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-RNO-73943:r:Reversal of alkylation damage by DNA dioxygenases", "R-MMU-73943:r:Reversal of alkylation damage by DNA dioxygenases"], "type": "Homologous_superfamily"}, "IPR038414": {"description": "Cbb3-type cytochrome c oxidase subunit CcoP, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CcoP_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038415": {"description": "Minor type IV pilin, PilX-like superfamily", "go_ids": [], "go_terms": [], "name": "Pilin_PilX-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038416": {"description": "Sigma 54 modulation/S30EA ribosomal protein, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosom_S30AE_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038417": {"description": "Alpha-galactosidase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Alpga-gal_N_sf", "pathway_ids": ["PWY-6527"], "pathways": ["PWY-6527:t:stachyose degradation"], "type": "Homologous_superfamily"}, "IPR038418": {"description": "6-pyruvoyl tetrahydropterin synthase/QueD superfamily", "go_ids": [], "go_terms": [], "name": "6-PTP_synth/QueD_sf", "pathway_ids": ["PWY-6703", "R-DME-1474151", "R-DDI-1474151", "R-CEL-1474151", "R-HSA-1474151", "R-MMU-1474151", "R-RNO-1474151"], "pathways": ["PWY-6703:t:preQ0 biosynthesis", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-DDI-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "type": "Homologous_superfamily"}, "IPR038419": {"description": "Poly(A) polymerase, nucleotidyltransferase domain superfamily, Poxvirus", "go_ids": [], "go_terms": [], "name": "PolyA_pol_nucTrfase_sf_Poxvir", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038420": {"description": "PapG, carbohydrate-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "PapG_carbohydrate-bd_sf", "pathway_ids": ["R-HSA-9638630"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells"], "type": "Homologous_superfamily"}, "IPR038421": {"description": "Sensor histidine kinase RisS, periplasmic domain superfamily", "go_ids": [], "go_terms": [], "name": "RisS_PPD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038422": {"description": "Cut8/Sts1 superfamily", "go_ids": [], "go_terms": [], "name": "Cut8/Sts1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038423": {"description": "Calcium-dependent cell adhesion molecule, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CAD_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038424": {"description": "Histidine kinase PdtaS, GAF domain superfamily", "go_ids": [], "go_terms": [], "name": "H_kinase_PdtaS_GAF_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038425": {"description": "GAT domain superfamily", "go_ids": [], "go_terms": [], "name": "GAT_sf", "pathway_ids": ["R-HSA-6798695", "R-RNO-8875656", "R-HSA-8854214", "R-MMU-8875656", "R-HSA-977225", "R-MMU-6798695", "R-HSA-8875656", "R-GGA-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-8875656:r:MET receptor recycling", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8875656:r:MET receptor recycling", "R-GGA-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR038426": {"description": "Vacuolar R-SNARE Nyv1, longin domain superfamily", "go_ids": [], "go_terms": [], "name": "Nyv1_longin_sf", "pathway_ids": ["R-SCE-199992"], "pathways": ["R-SCE-199992:r:trans-Golgi Network Vesicle Budding"], "type": "Homologous_superfamily"}, "IPR038428": {"description": "Two-component histidine kinase, sensor domain superfamily", "go_ids": [], "go_terms": [], "name": "HK_sensor_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038429": {"description": "PhoQ Sensor superfamily", "go_ids": [], "go_terms": [], "name": "PhoQ_Sensor_sf", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Homologous_superfamily"}, "IPR038430": {"description": "NADH:ubiquinone oxidoreductase, subunit 3 superfamily", "go_ids": [], "go_terms": [], "name": "NDAH_ubi_oxred_su3_sf", "pathway_ids": ["R-HSA-5419276", "R-SSC-5419276", "R-HSA-6799198", "R-MMU-6799198", "R-DME-6799198", "R-RNO-6799198", "R-DRE-611105", "R-SSC-6799198", "R-GGA-6799198", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-GGA-5419276", "R-RNO-5419276", "R-GGA-611105", "R-DRE-6799198", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-DRE-5419276", "R-BTA-6799198", "R-SSC-611105", "R-BTA-611105"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-SSC-6799198:r:Complex I biogenesis", "R-GGA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-611105:r:Respiratory electron transport", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-5419276:r:Mitochondrial translation termination", "R-BTA-6799198:r:Complex I biogenesis", "R-SSC-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Homologous_superfamily"}, "IPR038431": {"description": "Killer toxin SMK, beta subunit superfamily", "go_ids": [], "go_terms": [], "name": "Killer_tox_SMK_b_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038432": {"description": "PulS/OutS-like superfamily", "go_ids": [], "go_terms": [], "name": "PulS/OutS-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038434": {"description": "YARHG domain superfamily", "go_ids": [], "go_terms": [], "name": "YARHG_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038435": {"description": "Probable DNA packing protein, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DNA_pack_C_sf", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Homologous_superfamily"}, "IPR038436": {"description": "Effector protein NleG superfamily", "go_ids": [], "go_terms": [], "name": "Effector_NleG_sf", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Homologous_superfamily"}, "IPR038437": {"description": "GINS complex, subunit Psf3 superfamily", "go_ids": [], "go_terms": [], "name": "GINS_Psf3_sf", "pathway_ids": ["R-BTA-176974", "R-SPO-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974"], "pathways": ["R-BTA-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA"], "type": "Homologous_superfamily"}, "IPR038438": {"description": "Alanyl aminopeptidase, Ig-like domain superfamily", "go_ids": [], "go_terms": [], "name": "PepN_Ig-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038440": {"description": "FimV, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "FimV_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038441": {"description": "THAP-type zinc finger superfamily", "go_ids": [], "go_terms": [], "name": "THAP_Znf_sf", "pathway_ids": ["R-DME-9772755", "R-DME-6804759", "R-DME-3214847"], "pathways": ["R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-DME-3214847:r:HATs acetylate histones"], "type": "Homologous_superfamily"}, "IPR038442": {"description": "Dsl1, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Dsl1_N_sf", "pathway_ids": ["R-SCE-6811434"], "pathways": ["R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR038444": {"description": "DUF465 superfamily", "go_ids": [], "go_terms": [], "name": "DUF465_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038445": {"description": "Neutral ceramidase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NCDase_C_sf", "pathway_ids": ["PWY-6483", "PWY-7119", "R-DDI-9840310", "R-MMU-9840310", "R-RNO-9840310", "R-DME-9840310", "R-DRE-9840310", "R-HSA-9840310"], "pathways": ["PWY-6483:t:ceramide degradation (generic)", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-DME-9840310:r:Glycosphingolipid catabolism", "R-DRE-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism"], "type": "Homologous_superfamily"}, "IPR038446": {"description": "CEBP, ZZ domain superfamily", "go_ids": [], "go_terms": [], "name": "CEBP_ZZ_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038447": {"description": "PSRP-3/Ycf65 superfamily", "go_ids": [], "go_terms": [], "name": "PSRP-3/Ycf65_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038448": {"description": "Effector protein HopAB, E3 ubiquitin ligase domain superfamily", "go_ids": [], "go_terms": [], "name": "HopAB_E3_ubiquit_lig_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038449": {"description": "SirA superfamily", "go_ids": [], "go_terms": [], "name": "SirA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038450": {"description": "Photosystem II Psb27 superfamily", "go_ids": [], "go_terms": [], "name": "PSII_Psb27_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038451": {"description": "Arterivirus nsp7 alpha superfamily", "go_ids": [], "go_terms": [], "name": "Arteri_nsp7a_sf", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR038452": {"description": "Channel forming colicin, central receptor recognition domain superfamily", "go_ids": [], "go_terms": [], "name": "Channel_colicin_cen_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038453": {"description": "DUF3220 superfamily", "go_ids": [], "go_terms": [], "name": "DUF3220_sf", "pathway_ids": [], "pathways": [], "type": 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["R-CEL-9770562:r:mRNA Polyadenylation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Homologous_superfamily"}, "IPR038462": {"description": "YaiA-like superfamily", "go_ids": [], "go_terms": [], "name": "YaiA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038463": {"description": "CedA-like superfamily", "go_ids": [], "go_terms": [], "name": "CedA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038464": {"description": "Large ribosomal subunit protein eL38 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_eL38_sf", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", 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{"description": "MecA, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MecA_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038472": {"description": "DNA sulphur modification protein DndE superfamily", "go_ids": [], "go_terms": [], "name": "DndE_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038473": {"description": "VirC2, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "VirC2_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038474": {"description": "Polyketide synthesis cyclase superfamily", "go_ids": [], "go_terms": [], "name": "Polyketide_synth_cyclase_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038475": {"description": "RecG, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RecG_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038476": {"description": "UvrC, RNAse H endonuclease domain superfamily", "go_ids": [], "go_terms": [], "name": "UvrC_RNase_H_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038477": {"description": "Arylsulfotransferase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ASST_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038478": {"description": "Fimbrillin subunit EcpA superfamily", "go_ids": [], "go_terms": [], "name": "Fimbrillin_EcpA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038479": {"description": "Transthyretin-like superfamily", "go_ids": [], "go_terms": [], "name": "Transthyretin-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038480": {"description": "YuaB-like superfamily", "go_ids": [], "go_terms": [], "name": "YuaB-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038481": {"description": "Melampsora 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"Fiber protein, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Fiber_prot_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038487": {"description": "Mre11, capping domain", "go_ids": [], "go_terms": [], "name": "Mre11_capping_dom", "pathway_ids": ["R-HSA-5685942", "R-MMU-5693571", "R-HSA-5693616", "R-HSA-5693579", "R-MMU-1834949", "R-HSA-9704646", "R-RNO-5693565", "R-SCE-2559586", "R-MMU-6804756", "R-RNO-5685939", "R-HSA-5693565", "R-MMU-5693616", "R-RNO-5693548", "R-MMU-5685938", "R-MMU-5693565", "R-MMU-69473", "R-SCE-5693565", "R-HSA-9709570", "R-HSA-5693607", "R-GGA-351444", "R-RNO-5685938", "R-CEL-5685939", "R-HSA-912446", "R-HSA-1834949", "R-MMU-5685939", "R-SCE-5693548", "R-MMU-5693568", "R-RNO-6804756", "R-CEL-1834949", "R-MMU-5693579", "R-SPO-5685939", "R-GGA-351442", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-HSA-3270619", "R-CEL-5693548", "R-RNO-2559586", "R-MMU-5693548", "R-GGA-217106", 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"Homologous_superfamily"}, "IPR038488": {"description": "Integrase, DNA-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Integrase_DNA-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038489": {"description": "Suppressor of fused, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "SUFU_C_sf", "pathway_ids": ["R-HSA-5610780", "R-MMU-5610780", "R-HSA-5610785", "R-MMU-5632684", "R-MMU-5610785", "R-HSA-5610787", "R-MMU-5610787", "R-HSA-5610783", "R-HSA-5632684"], "pathways": ["R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-5632684:r:Hedgehog 'on' state"], "type": "Homologous_superfamily"}, "IPR038490": {"description": "Gingipain propeptide superfamily", "go_ids": [], "go_terms": [], "name": "Gingipain_propep_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038491": {"description": "Velvet domain superfamily", "go_ids": [], "go_terms": [], "name": "Velvet_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038492": {"description": "GBBH-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "GBBH-like_N_sf", "pathway_ids": ["R-RNO-71262", "R-MMU-71262", "R-CEL-71262", "R-GGA-71262", "R-HSA-71262", "R-BTA-71262"], "pathways": ["R-RNO-71262:r:Carnitine synthesis", "R-MMU-71262:r:Carnitine synthesis", "R-CEL-71262:r:Carnitine synthesis", "R-GGA-71262:r:Carnitine synthesis", "R-HSA-71262:r:Carnitine synthesis", "R-BTA-71262:r:Carnitine synthesis"], "type": "Homologous_superfamily"}, "IPR038493": {"description": "Toxin MqsR superfamily", "go_ids": [], 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"R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-BTA-77387:r:Insulin receptor recycling", "R-HSA-9636467:r:Blockage of phagosome acidification", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR038498": {"description": "OspF/SpvC superfamily", "go_ids": [], "go_terms": [], "name": "OspF/SpvC_sf", "pathway_ids": ["PWY-6254", "PWY-6653", "PWY-6160", "PWY-5725", "PWY-5197", "PWY-5414", "PWY-7721", "PWY-3041", "PWY-6275", "PWY-6257", "PWY-6258"], "pathways": ["PWY-6254:t:santalene 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["R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5210891:r:Uptake and function of anthrax toxins", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins"], "type": "Homologous_superfamily"}, "IPR038500": {"description": "Antitermination protein Q superfamily", "go_ids": [], "go_terms": [], "name": "Antitermination_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038501": {"description": "Spore germination GerAC, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Spore_GerAC_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038502": {"description": "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "M1_LTA-4_hydro/amino_C_sf", "pathway_ids": ["PWY-6423", "PWY-8397", "PWY-8356", "PWY-7694", "PWY-8399", "PWY-7954", "PWY-6710", "PWY-7778", "PWY-8400", "PWY-8395", "R-HSA-6798695", "R-HSA-2142691", "R-SPO-2142691", "R-SPO-6798695", "R-HSA-9018681", "R-HSA-9018676", "R-SCE-9020265", "R-CEL-6798695", "R-MMU-9018681", "R-RNO-9023661", "R-SCE-6798695", "R-BTA-9018681", "R-BTA-6798695", "R-SCE-9018896", "R-SPO-9018681", "R-CEL-9020265", "R-CEL-2142691", "R-MMU-9023661", "R-CEL-9018681", "R-BTA-9020265", "R-CEL-9023661", "R-SPO-9018896", "R-DDI-9020265", "R-RNO-9018896", "R-SCE-9023661", "R-HSA-9023661", "R-HSA-9018896", "R-DDI-2142691", "R-SCE-2142691", "R-SCE-9018676", "R-BTA-9023661", "R-RNO-9018676", "R-CEL-9018676", "R-MMU-9018676", "R-DDI-6798695", "R-BTA-9018896", "R-HSA-9020265", "R-DDI-9018681", "R-SPO-9020265", "R-BTA-2142691", "R-SPO-9018676", "R-DDI-9023661", "R-DDI-9018896", "R-RNO-2142691", "R-CEL-9018896", "R-SPO-9023661", "R-MMU-9020265", "R-MMU-2142691", "R-MMU-6798695", "R-RNO-9018681", "R-DDI-9018676", "R-SCE-9018681", "R-BTA-9018676", "R-RNO-9020265", "R-RNO-6798695", "R-MMU-9018896"], "pathways": ["PWY-6423:t:hemoglobin degradation", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8356:t:maresin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-6710:t:poly-hydroxy fatty acids biosynthesis", "PWY-7778:t:2-methylpropene degradation", "PWY-8400:t:docosahexaenoate metabolites biosynthesis", "PWY-8395:t:linoleate metabolites biosynthesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9018681:r:Biosynthesis of protectins", "R-HSA-9018676:r:Biosynthesis of D-series resolvins", "R-SCE-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-9018681:r:Biosynthesis of protectins", "R-RNO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-9018681:r:Biosynthesis of protectins", "R-BTA-6798695:r:Neutrophil degranulation", "R-SCE-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SPO-9018681:r:Biosynthesis of protectins", "R-CEL-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-CEL-9018681:r:Biosynthesis of protectins", "R-BTA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SPO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DDI-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SCE-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DDI-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SCE-9018676:r:Biosynthesis of D-series resolvins", "R-BTA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-CEL-9018676:r:Biosynthesis of D-series resolvins", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-DDI-9018681:r:Biosynthesis of protectins", "R-SPO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-9018676:r:Biosynthesis of D-series resolvins", "R-DDI-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-DDI-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SPO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9018681:r:Biosynthesis of protectins", "R-DDI-9018676:r:Biosynthesis of D-series resolvins", "R-SCE-9018681:r:Biosynthesis of protectins", "R-BTA-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins"], "type": "Homologous_superfamily"}, "IPR038503": {"description": "Stage III sporulation protein AH-like superfamily", "go_ids": [], "go_terms": [], "name": "SpoIIIAH_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038504": {"description": "UL141-like superfamily", "go_ids": [], "go_terms": [], "name": "UL141-like_sf", "pathway_ids": ["R-HSA-9610379"], "pathways": ["R-HSA-9610379:r:HCMV Late Events"], "type": "Homologous_superfamily"}, "IPR038505": {"description": "FANCF, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "FANCF_C_sf", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Homologous_superfamily"}, "IPR038506": {"description": "GLE1-like superfamily", "go_ids": [], "go_terms": [], "name": "GLE1-like_sf", "pathway_ids": ["R-RNO-159236", "R-BTA-159236", "R-HSA-159236", "R-DRE-159236", "R-DME-159236", "R-SPO-159236", "R-MMU-159236"], "pathways": ["R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Homologous_superfamily"}, "IPR038507": {"description": "YcnI-like superfamily", "go_ids": [], "go_terms": [], "name": "YcnI-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038508": {"description": "ArfGAP domain superfamily", "go_ids": [], "go_terms": [], "name": "ArfGAP_dom_sf", "pathway_ids": ["R-SPO-6807878", "R-HSA-9013409", "R-MMU-8856828", "R-HSA-8849469", "R-HSA-8856828", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-6811434", "R-MMU-9013420", "R-RNO-9013424", "R-DME-3928664", "R-RNO-9013408", "R-RNO-9013404", "R-RNO-9013406", "R-HSA-9013408", "R-DDI-193648", "R-MMU-6811434", "R-DME-9013149", "R-MMU-5620916", "R-SCE-6811434", "R-HSA-3928664", "R-RNO-5620916", "R-CEL-6807878", "R-HSA-373752", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013406", "R-SPO-6811434", "R-RNO-9013420", "R-BTA-6811434", "R-MMU-8980692", "R-HSA-1251985", "R-MMU-9013148", "R-DME-9013424", "R-MMU-6807878", "R-DDI-9013149", "R-HSA-9013423", "R-BTA-6807878", "R-HSA-5620916", "R-DME-5620916", "R-HSA-9013148", "R-DME-9013406", "R-HSA-9619229", "R-RNO-8856828", "R-DME-9013423", "R-MMU-3928664", "R-HSA-381038", "R-HSA-9013420", "R-SCE-6807878", "R-RNO-6811434", "R-RNO-8856825", "R-MMU-8849469", "R-RNO-6807878", "R-HSA-6807878", "R-MMU-9013424", "R-RNO-3928664", "R-RNO-9013423", "R-BTA-9013408", "R-HSA-8856825", "R-HSA-9013406", "R-MMU-9013149", "R-CEL-6811434", "R-DME-9013420"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-DME-3928664:r:Ephrin signaling", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DDI-193648:r:NRAGE signals death through JNK", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-3928664:r:Ephrin signaling", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-9013420:r:RHOU GTPase cycle", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-9013420:r:RHOU GTPase cycle", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-3928664:r:Ephrin signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Homologous_superfamily"}, "IPR038509": {"description": "IFS superfamily", "go_ids": [], "go_terms": [], "name": "IFS_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038510": {"description": "Spt4 superfamily", "go_ids": [], "go_terms": [], "name": "Spt4_sf", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-HSA-167238", "R-MMU-113418", "R-DME-6796648", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-DRE-6807505", "R-HSA-167287", "R-DRE-75955", "R-HSA-167246", "R-DRE-6796648", "R-DRE-113418", "R-HSA-167152", "R-HSA-113418", "R-SPO-6796648", "R-SCE-6796648", "R-SPO-113418", "R-DME-113418", "R-CEL-75955", "R-MMU-6796648", "R-DME-674695", "R-HSA-167243", "R-SCE-113418", "R-HSA-167242", "R-CEL-113418", "R-MMU-674695", "R-MMU-6807505", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-HSA-167290", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-SCE-674695", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Homologous_superfamily"}, "IPR038511": {"description": "TAP42/TAP46-like superfamily", "go_ids": [], "go_terms": [], "name": "TAP42/TAP46-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038512": {"description": "GpU-like superfamily", "go_ids": [], "go_terms": [], "name": "GpU-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038513": {"description": "FAIM1 domain superfamily", "go_ids": [], "go_terms": [], "name": "FAIM1_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038514": {"description": "AAR2, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "AAR2_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038515": {"description": "Two-component sensor protein CpxA, periplasmic domain superfamily", "go_ids": [], "go_terms": [], "name": "CpxA_peri_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038516": {"description": "AAR2, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "AAR2_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038517": {"description": "MxiM superfamily", "go_ids": [], "go_terms": [], "name": "MxiM_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038518": {"description": "Glycosyl hydrolase family 63, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_63N_sf", "pathway_ids": ["PWY-7918", "PWY-7919", "R-HSA-532668", "R-HSA-9683686", "R-HSA-9768727", "R-RNO-9768727", "R-MMU-9768727", "R-HSA-9694548", "R-HSA-4793954"], "pathways": ["PWY-7918:t:protein N-glycosylation processing phase (endoplasmic reticulum, yeast)", "PWY-7919:t:protein N-glycosylation processing phase (plants and animals)", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-4793954:r:Defective MOGS causes CDG-2b"], "type": "Homologous_superfamily"}, "IPR038519": {"description": "Major capsid protein, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MCP_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038520": {"description": "Matrix protein superfamily", "go_ids": [], "go_terms": [], "name": "BDV_M_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038521": {"description": "ThiC/Bza, core domain", "go_ids": [], "go_terms": [], "name": "ThiC/Bza_core_dom", "pathway_ids": ["PWY-6890"], "pathways": ["PWY-6890:t:4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I"], "type": "Homologous_superfamily"}, "IPR038522": {"description": "Type IV / VI secretion system, DotU superfamily", "go_ids": [], "go_terms": [], "name": "T4/T6SS_DotU_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038523": {"description": "AmiS/UreI transporter superfamily", "go_ids": [], "go_terms": [], "name": "AmiSUreI_transpt_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038525": {"description": "ATR13 superfamily", "go_ids": [], "go_terms": [], "name": "ATR13_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038526": {"description": "Large ribosomal subunit protein eL22 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_eL22_sf", "pathway_ids": ["R-XTR-6791226", "R-CEL-975957", "R-HSA-9010553", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-XTR-9954716", "R-CEL-72706", "R-XTR-1799339", "R-GGA-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-RNO-156827", "R-MMU-9954714", "R-XTR-9954714", "R-SSC-9954714", "R-CEL-1799339", "R-HSA-72706", "R-GGA-9954716", "R-CEL-156827", "R-RNO-6791226", "R-SSC-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SSC-72689", "R-XTR-72706", "R-HSA-9954714", "R-CEL-72689", "R-MMU-1799339", "R-GGA-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-72689", "R-XTR-975956", "R-HSA-156827", "R-XTR-9954709", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-XTR-975957", "R-SSC-156827", "R-HSA-9954709", "R-DME-1799339", "R-GGA-9954714", "R-MMU-975956", "R-DME-975956", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-XTR-156827", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SSC-9954709", "R-MMU-156827", "R-GGA-9954709", "R-GGA-975957", "R-HSA-975957", "R-DME-9954714", "R-SSC-6791226", "R-GGA-1799339", "R-DME-975957", "R-SSC-9954716", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-XTR-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal 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"R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-XTR-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-9954709:r:Ribosome Quality 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Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR038527": {"description": "HupH, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "HupH_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038528": {"description": "TEL2, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "TEL2_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038529": {"description": "FPRL1/chemotaxis inhibitory protein superfamily", "go_ids": [], "go_terms": [], "name": "FLIPR/CHIP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038530": {"description": "[NiFe]-hydrogenase assembly chaperone, HybE superfamily", "go_ids": [], "go_terms": [], "name": "NiFe-hyd_HybE_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038531": {"description": "Neuraminyllactose-binding hemagglutinin superfamily", "go_ids": [], "go_terms": [], "name": "NeuraminylLac-bd_hemagglutn_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038532": {"description": "NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily", "go_ids": [], "go_terms": [], "name": "NDUFS4-like_sf", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-MMU-611105", "R-RNO-6799198", "R-BTA-6799198", "R-DME-611105", "R-BTA-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-RNO-6799198:r:Complex I biogenesis", "R-BTA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Homologous_superfamily"}, "IPR038533": {"description": "UpxZ superfamily", "go_ids": [], "go_terms": [], "name": "UpxZ_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038534": {"description": "Rtr1/RPAP2 domain superfamily", "go_ids": [], "go_terms": [], "name": "Rtr1/RPAP2_sf", "pathway_ids": ["R-SCE-6807505", "R-CEL-6807505", "R-HSA-6807505", "R-RNO-6807505", "R-MMU-6807505", "R-DRE-6807505"], "pathways": ["R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Homologous_superfamily"}, "IPR038535": {"description": "CCR4-NOT subunit 1, TTP binding domain superfamily", "go_ids": [], "go_terms": [], "name": "CNOT1_TTP_bind_sf", "pathway_ids": ["R-XTR-429947", "R-MMU-6804115", "R-HSA-6804115", "R-XTR-6804115", "R-DRE-6804115", "R-HSA-429947", "R-MMU-429947", "R-HSA-9820841"], "pathways": ["R-XTR-429947:r:Deadenylation of mRNA", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Homologous_superfamily"}, "IPR038536": {"description": "Alkyl/aryl-sulfatase, dimerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "Alkyl/aryl-sulf_dimr_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038537": {"description": "TRAP transporter T-component superfamily", "go_ids": [], "go_terms": [], "name": "TatT_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038538": {"description": "MTERF superfamily, mitochondrial/chloroplastic", "go_ids": [], "go_terms": [], "name": "MTERF_sf", "pathway_ids": ["R-HSA-9937008", "R-HSA-6793080", "R-HSA-2151201", "R-RNO-5205685", "R-DME-5205685", "R-HSA-163316", "R-HSA-5205685", "R-MMU-5205685", "R-MMU-163316", "R-RNO-163316", "R-DME-163316"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-163316:r:Mitochondrial transcription termination", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-163316:r:Mitochondrial transcription termination", "R-RNO-163316:r:Mitochondrial transcription termination", "R-DME-163316:r:Mitochondrial transcription termination"], "type": "Homologous_superfamily"}, "IPR038539": {"description": "Anti-lipopolysaccharide factor/Scygonadin superfamily", "go_ids": [], "go_terms": [], "name": "Anti-LPS_factor/Scygonadin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038540": {"description": "Pathogenicity island protein gp6 superfamily", "go_ids": [], "go_terms": [], "name": "SAPIS-gp6_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038542": {"description": "Spidroin, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Spidroin_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038543": {"description": "Churchill superfamily", "go_ids": [], "go_terms": [], "name": "Churchill_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038544": {"description": "ACP, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "ACP_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038545": {"description": "DBF-type zinc finger superfamily", "go_ids": [], "go_terms": [], "name": "Znf_DBF_sf", "pathway_ids": ["R-DME-68962", "R-SPO-176187", "R-XTR-68962", "R-MMU-68962", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-HSA-176187", "R-SCE-176187", "R-SCE-68962", "R-DME-176187"], "pathways": ["R-DME-68962:r:Activation of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Homologous_superfamily"}, "IPR038546": {"description": "Hen1, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Hen1_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038547": {"description": "CBP/p300, atypical RING domain superfamily", "go_ids": [], "go_terms": [], "name": "RING_CBP-p300_sf", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-MMU-8941858", "R-RNO-933541", "R-HSA-8936459", "R-CEL-9701898", "R-RNO-9018519", "R-HSA-9818030", "R-CEL-9617629", "R-HSA-9616222", "R-HSA-9701898", "R-HSA-9614657", "R-HSA-2122947", "R-MMU-6804760", "R-HSA-9931521", "R-HSA-6804760", "R-RNO-9759194", "R-MMU-3371568", "R-CEL-8939246", "R-MMU-350054", "R-HSA-6804114", "R-MMU-6804758", "R-HSA-9793380", "R-RNO-9841922", "R-RNO-5621575", "R-HSA-2644606", "R-HSA-9031628", "R-HSA-9768919", "R-HSA-9833109", "R-CEL-8951936", "R-HSA-8941856", "R-HSA-9705671", "R-CEL-8936459", "R-MMU-2122947", "R-HSA-9735871", "R-CEL-3899300", "R-MMU-9759194", "R-MMU-9029569", "R-HSA-3371568", "R-HSA-9818028", "R-HSA-9617629", "R-RNO-400206", "R-MMU-8951936", "R-HSA-9839394", "R-MMU-3899300", "R-RNO-9856649", "R-HSA-210744", "R-HSA-156711", "R-HSA-381340", "R-MMU-8866907", "R-MMU-9701898", "R-HSA-9707616", "R-HSA-6811555", "R-HSA-350054", "R-HSA-201722", "R-HSA-933541", "R-HSA-9909649", "R-RNO-8941856", "R-RNO-8866907", "R-CEL-9018519", "R-HSA-3214847", "R-HSA-9856649", "R-RNO-9617629", "R-HSA-2426168", "R-MMU-9707564", "R-MMU-9856649", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-1234158", "R-MMU-5689901", "R-MMU-201722", "R-MMU-8939246", "R-HSA-9818749", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-1234158", "R-RNO-350054", "R-HSA-9933387", "R-HSA-9707564", "R-CEL-9856649", "R-HSA-9018519", "R-HSA-8951936", "R-RNO-3134973", "R-MMU-8936459", "R-MMU-5250924", "R-MMU-5621575", "R-HSA-8941858", "R-MMU-3134973", "R-CEL-9759194", "R-MMU-9018519", "R-HSA-9013695", "R-HSA-8939243", "R-HSA-9818026", "R-HSA-400206", "R-HSA-3134973", "R-MMU-400206", "R-HSA-5617472", "R-HSA-9818027", "R-HSA-5689901", "R-HSA-9819196", "R-MMU-933541", "R-RNO-201722", "R-HSA-9818035", "R-CEL-201722", "R-MMU-9617629", "R-RNO-8939246", "R-HSA-1912408", "R-HSA-6804758", "R-RNO-3371568", "R-HSA-918233", "R-HSA-5621575", "R-HSA-9759194", "R-HSA-9029569", "R-HSA-2173796", "R-HSA-9931509", "R-CEL-1234158", "R-HSA-8866907", "R-HSA-9013508", "R-HSA-2894862", "R-RNO-9707564", "R-MMU-8939243", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-6803204", "R-HSA-9818032", "R-MMU-8941856", "R-HSA-5250924", "R-MMU-6811555", "R-RNO-1234158", "R-HSA-3899300", "R-HSA-2197563", "R-HSA-8939246", "R-CEL-8939243"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-CEL-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9759194:r:Nuclear events mediated 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{"description": "Beta-1,3-xylanase, CBM31 domain superfamily", "go_ids": [], "go_terms": [], "name": "Beta-xylanase_CBM31_sf", "pathway_ids": ["PWY-6789"], "pathways": ["PWY-6789:t:(1,3)-beta-D-xylan degradation"], "type": "Homologous_superfamily"}, "IPR038561": {"description": "Sarcosine oxidase subunit delta superfamily", "go_ids": [], "go_terms": [], "name": "SoxD_sf", "pathway_ids": ["PWY-3661"], "pathways": ["PWY-3661:t:glycine betaine degradation I"], "type": "Homologous_superfamily"}, "IPR038562": {"description": "Large ribosomal subunit protein eL34, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_eL34_C_sf", "pathway_ids": ["R-HSA-9954716", "R-MMU-72689", "R-HSA-9010553", "R-HSA-156827", "R-DRE-9954709", "R-MMU-9954709", "R-HSA-192823", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-SSC-156827", "R-HSA-9954709", "R-SSC-72706", "R-MMU-975956", "R-HSA-1799339", "R-DRE-156827", "R-HSA-2408557", "R-DRE-975956", "R-MMU-6791226", "R-DRE-9954714", 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"PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Homologous_superfamily"}, "IPR038569": {"description": "Bacteriophage T4, IpI C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Phage_T4_IpI_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038570": {"description": "HicA superfamily", "go_ids": [], "go_terms": [], "name": "HicA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038571": {"description": "Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase, domain 3 superfamily", "go_ids": [], "go_terms": [], "name": "CO_DH/Ac-CoA_synth_bsu_3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038572": {"description": "Stomagen, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Stomagen_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038573": {"description": "Ribonuclease toxin BrnT superfamily", "go_ids": [], "go_terms": [], "name": "BrnT_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038575": {"description": "E6 superfamily", "go_ids": [], "go_terms": [], "name": "E6_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038576": {"description": "Methyltransferase putative zinc binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Methyltransf_Zn-bd_dom_put_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038577": {"description": "GT10-like, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "GT10-like_C_sf", "pathway_ids": ["R-DRE-5173105", "R-RNO-9037629", 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"R-DME-8866427", "R-BTA-5654727", "R-RNO-2173788", "R-MMU-9755511", "R-MMU-9954709", "R-BTA-937072", "R-BTA-2672351", "R-HSA-2871837", "R-RNO-5689603", "R-MMU-9931295", "R-RNO-8849469", "R-GGA-8863795", "R-HSA-5362768", "R-GGA-174113", "R-RNO-8852276", "R-GGA-5668541", "R-BTA-6807004", "R-BTA-174178", "R-RNO-937039", "R-MMU-5655862", "R-BTA-8948751", "R-BTA-3769402", "R-HSA-9013973", "R-HSA-2173791", "R-RNO-9929491", "R-BTA-5205685", "R-HSA-2894862", "R-GGA-434001", "R-RNO-110320", "R-HSA-9754678", "R-HSA-5632684", "R-BTA-8854050", "R-HSA-9683683", "R-HSA-8876493", "R-GGA-5696395", "R-RNO-5607764", "R-GGA-2672351", "R-MMU-5654733", "R-BTA-5607764", "R-HSA-69541", "R-RNO-182971", "R-GGA-75815", "R-GGA-937042", "R-RNO-6781823", "R-GGA-5689603", "R-GGA-937041", "R-HSA-5689880", "R-BTA-1234176", "R-GGA-110314", "R-RNO-5693565", "R-MMU-69017", "R-RNO-5655862", "R-DME-5654732", "R-RNO-5689901", "R-RNO-8863795", "R-BTA-450321", "R-DME-2467813", "R-RNO-937042", "R-BTA-936964", "R-DME-1295596", "R-BTA-2173795", "R-GGA-5632684", "R-BTA-5689901", "R-HSA-1234176", "R-RNO-4641258", "R-MMU-6804760", "R-DME-2559582", "R-HSA-9931269", "R-HSA-2408557", "R-MMU-975144", "R-DME-174048", "R-HSA-182971", "R-RNO-5654732", "R-MMU-68867", "R-BTA-182971", "R-BTA-6782135", "R-DME-209461", "R-MMU-450321", "R-BTA-2173788", "R-HSA-6804760", "R-HSA-72702", "R-BTA-5684264", "R-DME-9861718", "R-GGA-937072", "R-GGA-9013507", "R-BTA-5675221", "R-DME-75815", "R-GGA-209543", "R-BTA-917937", "R-HSA-5696394", "R-DME-69601", "R-GGA-2559582", "R-HSA-2644606", "R-DME-182971", "R-MMU-5675221", "R-DME-69017", "R-DME-983168", "R-GGA-983168", "R-GGA-9758274", "R-DME-1358803", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-6781827", "R-HSA-2467813", "R-HSA-168928", "R-HSA-937042", "R-BTA-195253", "R-HSA-9824878", "R-RNO-69601", "R-GGA-5610785", "R-HSA-9861718", "R-DME-937039", "R-MMU-9664873", "R-MMU-8939236", "R-MMU-917937", "R-RNO-4641257", "R-MMU-532668", "R-MMU-9762114", "R-BTA-5696400", "R-HSA-5689877", "R-MMU-205043", "R-GGA-349425", "R-GGA-9033241", "R-MMU-195253", "R-MMU-202424", "R-BTA-8856828", "R-MMU-382556", "R-BTA-9705462", "R-GGA-6783310", "R-DME-209360", "R-BTA-5632684", "R-DME-5357905", "R-RNO-9664873", "R-BTA-9931269", "R-MMU-6804757", "R-RNO-75815", "R-MMU-1169091", "R-BTA-1295596", "R-HSA-72649", "R-DME-8854050", "R-RNO-6807004", "R-MMU-8939902", "R-RNO-9770562", "R-GGA-1169091", "R-HSA-5696400", "R-BTA-917729", "R-HSA-8875360", "R-HSA-8939236", "R-BTA-2122948", "R-BTA-983168", "R-BTA-69231", "R-RNO-5654726", "R-MMU-5607764", "R-DME-6781823", "R-GGA-9664873", "R-DME-69231", "R-BTA-5668541", "R-DME-5656121", "R-GGA-5358346", "R-HSA-5676590", "R-MMU-69541", "R-DME-9954716", "R-HSA-975956", "R-RNO-2173795", "R-GGA-5687128", "R-HSA-3322077", "R-HSA-4641257", "R-RNO-202424", "R-GGA-5693565", "R-HSA-174113", "R-HSA-174490", "R-MMU-975163", "R-BTA-9762114", "R-GGA-2173795", "R-RNO-5607761", "R-HSA-5656121", "R-GGA-5696400", "R-GGA-4641257", "R-HSA-1799339", "R-HSA-9694493", "R-BTA-937042", "R-GGA-8849469", "R-RNO-917937", "R-DME-5689877", "R-HSA-9755511", "R-RNO-9013507", "R-RNO-9931269", "R-HSA-110312", "R-BTA-912631", "R-DME-2173791", "R-DME-3769402", "R-DME-3134975", "R-GGA-8948747", "R-HSA-1169091", "R-GGA-174178", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-8866427", "R-RNO-532668", "R-HSA-1253288", "R-MMU-9931269", "R-BTA-6783310", "R-HSA-3134975", "R-RNO-445989", "R-HSA-9613829", "R-HSA-8948751", "R-RNO-5689896", "R-MMU-5696397", "R-DME-450408", "R-RNO-2122948", "R-HSA-110314", "R-BTA-8939902", "R-BTA-9766229", "R-HSA-5689901", "R-GGA-9931295", "R-HSA-187577", "R-HSA-901032", "R-HSA-2122948", "R-GGA-573298", "R-DME-382556", "R-HSA-209543", "R-GGA-4641258", "R-DME-5610780", "R-HSA-2559585", "R-DME-195253", "R-MMU-69601", "R-RNO-2672351", "R-BTA-5654732", "R-DME-110312", "R-HSA-1236382", "R-DME-5607761", "R-GGA-69541", "R-DME-8856828", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5656169", "R-HSA-937072", "R-HSA-5607764", "R-HSA-2173796", "R-GGA-353299", "R-MMU-1358803", "R-RNO-8948747", "R-MMU-3769402", "R-RNO-4608870", "R-GGA-5696397", "R-MMU-8849469", "R-BTA-9664873", "R-DME-9033241", "R-BTA-2173791", "R-RNO-6782135", "R-RNO-5684264", "R-BTA-174048", "R-GGA-5357905", "R-BTA-6804760", "R-DME-532668", "R-DME-538864", "R-GGA-2173791", "R-GGA-975957", "R-GGA-174184", "R-HSA-5668541", "R-DME-5632684", "R-HSA-5687128", "R-DME-432395", "R-BTA-450302", "R-RNO-909733", "R-HSA-9705462", "R-RNO-5357956", "R-MMU-936440", "R-MMU-9758274", "R-GGA-437986", "R-HSA-110320", "R-BTA-975163"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-69231:r:Cyclin D associated events in G1", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-68949:r:Orc1 removal from chromatin", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-209560:r:NF-kB is activated and signals survival", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-GGA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-5689877:r:Josephin domain DUBs", "R-DME-5689901:r:Metalloprotease DUBs", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-6807004:r:Negative regulation of MET activity", "R-GGA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-GGA-1295596:r:Spry regulation of FGF signaling", "R-GGA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-912631:r:Regulation of signaling by CBL", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-GGA-5689880:r:Ub-specific processing proteases", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-GGA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-BTA-9033241:r:Peroxisomal protein import", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-GGA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-GGA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-382556:r:ABC-family proteins mediated transport", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-DME-8948747:r:Regulation of PTEN localization", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-GGA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-901032:r:ER Quality Control Compartment (ERQC)", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-9648002:r:RAS processing", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-GGA-68867:r:Assembly of the pre-replicative complex", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-8948747:r:Regulation of PTEN localization", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-9646399:r:Aggrephagy", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-9648002:r:RAS processing", "R-MMU-110312:r:Translesion synthesis by REV1", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-192823:r:Viral mRNA Translation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-GGA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-GGA-353303:r:Nucleotide Excision Repair", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-GGA-8939902:r:Regulation of RUNX2 expression and activity", "R-GGA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-5689603:r:UCH proteinases", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-BTA-9020702:r:Interleukin-1 signaling", "R-GGA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-GGA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-202424:r:Downstream TCR signaling", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-69481:r:G2/M Checkpoints", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-GGA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-MMU-5689877:r:Josephin domain DUBs", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-GGA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-DME-9648002:r:RAS processing", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9646399:r:Aggrephagy", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8951664:r:Neddylation", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-GGA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9648002:r:RAS processing", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9664873:r:Pexophagy", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-GGA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-901032:r:ER Quality Control Compartment (ERQC)", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2672351:r:Stimuli-sensing channels", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-68949:r:Orc1 removal from chromatin", "R-GGA-8951664:r:Neddylation", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-69541:r:Stabilization of p53", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-GGA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-GGA-9770562:r:mRNA Polyadenylation", "R-HSA-9615710:r:Late endosomal microautophagy", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-917937:r:Iron uptake and transport", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-GGA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-912631:r:Regulation of signaling by CBL", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-MMU-9706369:r:Negative regulation of FLT3", "R-DME-9646399:r:Aggrephagy", "R-GGA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-5696400:r:Dual Incision in GG-NER", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-RNO-9646399:r:Aggrephagy", "R-MMU-6807004:r:Negative regulation of MET activity", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-MMU-182971:r:EGFR downregulation", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-GGA-5689896:r:Ovarian tumor domain proteases", "R-DME-209560:r:NF-kB is activated and signals survival", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-8951664:r:Neddylation", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-GGA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-9766229:r:Degradation of CDH1", "R-GGA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-GGA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-69231:r:Cyclin D associated events in G1", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-110320:r:Translesion Synthesis by POLH", "R-GGA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-1227888:r:Negative Regulation of MDA5 signaling", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-5675482:r:Regulation of necroptotic cell death", "R-DME-110320:r:Translesion Synthesis by POLH", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-1253288:r:Downregulation of ERBB4 signaling", "R-GGA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5689603:r:UCH proteinases", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-BTA-8951664:r:Neddylation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-110312:r:Translesion synthesis by REV1", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-9861718:r:Regulation of pyruvate metabolism", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-9648002:r:RAS processing", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-5689877:r:Josephin domain DUBs", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-GGA-201681:r:TCF dependent signaling in response to WNT", "R-GGA-182971:r:EGFR downregulation", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-GGA-5689901:r:Metalloprotease DUBs", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-912631:r:Regulation of signaling by CBL", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-DME-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DME-5655862:r:Translesion synthesis by POLK", "R-BTA-69481:r:G2/M Checkpoints", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-9664873:r:Pexophagy", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-9766229:r:Degradation of CDH1", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-GGA-433871:r:TRAF6 mediated induction of proinflammatory cytokines", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-GGA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-GGA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-GGA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-GGA-9646399:r:Aggrephagy", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-GGA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-GGA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9770562:r:mRNA Polyadenylation", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-9020702:r:Interleukin-1 signaling", "R-GGA-901032:r:ER Quality Control Compartment (ERQC)", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-GGA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-RNO-110312:r:Translesion synthesis by REV1", "R-GGA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-912631:r:Regulation of signaling by CBL", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5689877:r:Josephin domain DUBs", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-GGA-6782135:r:Dual incision in TC-NER", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-9706369:r:Negative regulation of FLT3", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-GGA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-4641258:r:Degradation of DVL", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-4641258:r:Degradation of DVL", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-4641257:r:Degradation of AXIN", "R-RNO-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-GGA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-BTA-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-BTA-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-2672351:r:Stimuli-sensing channels", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-GGA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-GGA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-6807004:r:Negative regulation of MET activity", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9683683:r:Maturation of protein E", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-GGA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-GGA-2672351:r:Stimuli-sensing channels", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-69541:r:Stabilization of p53", "R-RNO-182971:r:EGFR downregulation", "R-GGA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-GGA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-5689603:r:UCH proteinases", "R-GGA-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DME-2467813:r:Separation of Sister Chromatids", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-GGA-5632684:r:Hedgehog 'on' state", "R-BTA-5689901:r:Metalloprotease DUBs", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-BTA-182971:r:EGFR downregulation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-GGA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-GGA-209543:r:p75NTR recruits signalling complexes", "R-BTA-917937:r:Iron uptake and transport", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-GGA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-DME-182971:r:EGFR downregulation", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-9758274:r:Regulation of NF-kappa B signaling", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-MMU-9664873:r:Pexophagy", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-917937:r:Iron uptake and transport", "R-RNO-4641257:r:Degradation of AXIN", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-5689877:r:Josephin domain DUBs", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-GGA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-9033241:r:Peroxisomal protein import", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-6783310:r:Fanconi Anemia Pathway", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-RNO-9664873:r:Pexophagy", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-HSA-72649:r:Translation initiation complex formation", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-9770562:r:mRNA Polyadenylation", "R-GGA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-69231:r:Cyclin D associated events in G1", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-9664873:r:Pexophagy", "R-DME-69231:r:Cyclin D associated events in G1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5656121:r:Translesion synthesis by POLI", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-69541:r:Stabilization of p53", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-GGA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-3322077:r:Glycogen synthesis", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-GGA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5656121:r:Translesion synthesis by POLI", 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polymerases", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-8948747:r:Regulation of PTEN localization", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-9664873:r:Pexophagy", "R-DME-9033241:r:Peroxisomal protein import", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-6782135:r:Dual incision in TC-NER", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-538864:r:Degradation of CRY", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-GGA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-432395:r:Degradation of TIM", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": 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"R-DME-2565942", "R-MMU-5357956", "R-MMU-174178", "R-CEL-8854050", "R-DDI-1358803", "R-BTA-936440", "R-BTA-209543", "R-RNO-9645460", "R-CFA-5693565", "R-CFA-9770562", "R-DME-1799339", "R-BTA-445989", "R-HSA-6782210", "R-GGA-1227882", "R-DDI-917729", "R-SSC-5358346", "R-MMU-936964", "R-HSA-195253", "R-HSA-9706369", "R-CFA-68867", "R-BTA-187577", "R-DDI-936440", "R-CFA-69231", "R-DME-2173795", "R-HSA-6807004", "R-CEL-2672351", "R-MMU-5656121", "R-HSA-8866427", "R-MMU-174184", "R-RNO-187577", "R-HSA-8856825", "R-MMU-5654727", "R-CFA-174084", "R-DME-9020702", "R-DDI-975957", "R-RNO-69017", "R-MMU-937041", "R-RNO-72706", "R-CEL-8948747", "R-RNO-2559582", "R-DDI-937072", "R-RNO-5357905", "R-CFA-4641258", "R-HSA-450321", "R-MMU-72706", "R-HSA-5693607", "R-RNO-5689877", "R-BTA-937041", "R-RNO-205043", "R-BTA-5693607", "R-BTA-9706369", "R-DDI-901032", "R-RNO-8866427", "R-RNO-9929356", "R-BTA-8863795", "R-BTA-156827", "R-MMU-209543", "R-SSC-9645460", "R-HSA-9918432", "R-BTA-5687128", "R-HSA-5678895", "R-BTA-1358803", "R-MMU-2559580", "R-CFA-5685942", "R-RNO-174184", "R-BTA-8866652", "R-MMU-4641257", "R-CFA-179409", "R-BTA-9770562", "R-HSA-975110", "R-MMU-2173788", "R-CEL-5689896", "R-DDI-8866654", "R-BTA-5654726", "R-DME-9954709", "R-CFA-8948751", "R-HSA-977225", "R-CFA-8866652", "R-DME-8866427", "R-CFA-8941858", "R-BTA-5654727", "R-MMU-9755511", "R-RNO-2173788", "R-BTA-937072", "R-BTA-2672351", "R-MMU-9931295", "R-RNO-5689603", "R-RNO-8849469", "R-CFA-4608870", "R-RNO-937039", "R-DDI-69017", "R-MMU-5655862", "R-BTA-8948751", "R-RNO-9929491", "R-CEL-5675221", "R-HSA-9013973", "R-BTA-5205685", "R-CFA-5607764", "R-HSA-2894862", "R-HSA-5632684", "R-CFA-209543", "R-SSC-2467813", "R-SSC-2871837", "R-HSA-8876493", "R-RNO-5607764", "R-MMU-5654733", "R-SSC-5676590", "R-RNO-182971", "R-RNO-6781823", "R-SSC-937039", "R-BTA-1234176", "R-RNO-5693565", "R-MMU-69017", "R-RNO-5655862", "R-CFA-69481", "R-CFA-2672351", "R-SSC-69231", "R-CFA-8939902", "R-RNO-5689901", "R-RNO-8863795", "R-DDI-179409", "R-SSC-5687128", "R-CEL-110320", "R-CFA-8866427", "R-DME-2467813", "R-RNO-937042", "R-BTA-2173795", "R-BTA-936964", "R-SSC-110312", "R-BTA-5689901", "R-MMU-6804760", "R-CEL-2173788", "R-CEL-917937", "R-MMU-975144", "R-RNO-4641258", "R-HSA-9931269", "R-HSA-2408557", "R-MMU-450321", "R-CEL-6782210", "R-BTA-5684264", "R-DME-9861718", "R-CEL-9648002", "R-BTA-5675221", "R-SSC-179409", "R-DME-75815", "R-CFA-4641263", "R-DME-182971", "R-CFA-909733", "R-HSA-5610785", "R-DME-1358803", "R-SSC-5689896", "R-SSC-69017", "R-SSC-2173795", "R-HSA-9824878", "R-CEL-983168", "R-DME-937039", "R-MMU-8939236", "R-RNO-4641257", "R-BTA-72706", "R-DDI-5689603", "R-SSC-174154", "R-MMU-532668", "R-HSA-5689877", "R-SSC-9020702", "R-MMU-202424", "R-BTA-5632684", "R-DDI-5687128", "R-RNO-9664873", "R-CFA-9033241", "R-CFA-8852276", "R-BTA-9931269", "R-SSC-9708530", "R-MMU-6804757", "R-CFA-5696400", "R-BTA-1295596", "R-CEL-9931269", "R-MMU-156827", "R-SSC-937041", "R-RNO-6807004", "R-MMU-8939902", "R-CFA-5689877", "R-CFA-9706369", "R-BTA-917729", "R-CFA-5357905", "R-SSC-174048", "R-HSA-8875360", "R-HSA-8939236", "R-BTA-2122948", "R-BTA-983168", "R-RNO-5654726", "R-DME-6781823", "R-CEL-912631", "R-DDI-9646399", "R-SSC-5654732", "R-MMU-69541", "R-DDI-5632684", "R-HSA-975956", "R-RNO-2173795", "R-CFA-2173791", "R-SSC-901032", "R-HSA-4641257", "R-RNO-202424", "R-HSA-174113", "R-BTA-9762114", "R-CFA-9954709", "R-HSA-5656121", "R-RNO-975957", "R-HSA-9694493", "R-RNO-917937", "R-RNO-9013507", "R-RNO-9931269", "R-HSA-9755511", "R-BTA-912631", "R-DME-3134975", "R-CFA-9646399", "R-MMU-8866427", "R-BTA-6783310", "R-MMU-9931269", "R-DDI-68949", "R-SSC-72689", "R-RNO-445989", "R-HSA-8948751", "R-DDI-9758274", "R-RNO-5689896", "R-MMU-5696397", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-CFA-110320", "R-DME-156827", "R-DDI-9755511", "R-GGA-573298", "R-HSA-2122948", "R-CFA-9762114", "R-HSA-2559585", "R-SSC-174178", "R-RNO-72689", "R-SSC-5696397", "R-CEL-936440", "R-DME-8856828", "R-CFA-450408", "R-MMU-5689603", "R-GGA-353299", "R-HSA-2173796", "R-SSC-2672351", "R-SSC-6804757", "R-RNO-4608870", "R-MMU-8849469", "R-BTA-9664873", "R-SSC-5696394", "R-BTA-174048", "R-RNO-5684264", "R-CEL-5655862"], "pathways": ["R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CFA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-CFA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5357905:r:Regulation of TNFR1 signaling", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-912631:r:Regulation of signaling by CBL", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-432524:r:Degradation of PER", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-CFA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SSC-9932298:r:Degradation of CRY and PER proteins", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-5689901:r:Metalloprotease DUBs", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-SSC-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-SSC-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-9770562:r:mRNA Polyadenylation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CFA-6804760:r:Regulation of TP53 Activity through Methylation", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-5689880:r:Ub-specific processing proteases", "R-CFA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SSC-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-CFA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-4641263:r:Regulation of FZD by ubiquitination", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-9648002:r:RAS processing", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-CFA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CFA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-5655862:r:Translesion synthesis by POLK", "R-SSC-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-BTA-9033241:r:Peroxisomal protein import", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-CFA-9664873:r:Pexophagy", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-DME-8948747:r:Regulation of PTEN localization", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-110312:r:Translesion synthesis by REV1", "R-BTA-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-CFA-6782135:r:Dual incision in TC-NER", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-CFA-4641257:r:Degradation of AXIN", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-SSC-68949:r:Orc1 removal from chromatin", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-8948747:r:Regulation of PTEN localization", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-BTA-9646399:r:Aggrephagy", "R-CFA-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CFA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-8948747:r:Regulation of PTEN localization", "R-MMU-110312:r:Translesion synthesis by REV1", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CFA-5689880:r:Ub-specific processing proteases", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-SSC-9706369:r:Negative regulation of FLT3", "R-DME-5689603:r:UCH proteinases", "R-MMU-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-CFA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SSC-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-SSC-5632684:r:Hedgehog 'on' state", "R-SSC-182971:r:EGFR downregulation", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-5685942:r:HDR through Homologous Recombination (HRR)", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-SSC-209543:r:p75NTR recruits signalling complexes", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-69481:r:G2/M Checkpoints", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-5689877:r:Josephin domain DUBs", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-SSC-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-382556:r:ABC-family proteins mediated transport", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-1295596:r:Spry regulation of FGF signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-9648002:r:RAS processing", "R-RNO-72649:r:Translation initiation complex formation", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9646399:r:Aggrephagy", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9664873:r:Pexophagy", "R-SSC-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9615710:r:Late endosomal microautophagy", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-917937:r:Iron uptake and transport", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SSC-6783310:r:Fanconi Anemia Pathway", "R-SSC-6782135:r:Dual incision in TC-NER", "R-DDI-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-9646399:r:Aggrephagy", "R-CFA-182971:r:EGFR downregulation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5689880:r:Ub-specific processing proteases", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-MMU-6807004:r:Negative regulation of MET activity", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-5696400:r:Dual Incision in GG-NER", "R-SSC-9770562:r:mRNA Polyadenylation", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-DDI-5358346:r:Hedgehog ligand biogenesis", "R-DME-209560:r:NF-kB is activated and signals survival", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CFA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-CFA-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-5675221:r:Negative regulation of MAPK pathway", "R-CFA-69541:r:Stabilization of p53", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-1227888:r:Negative Regulation of MDA5 signaling", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DME-110320:r:Translesion Synthesis by POLH", "R-SSC-5656169:r:Termination of translesion DNA synthesis", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-1253288:r:Downregulation of ERBB4 signaling", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-912631:r:Regulation of signaling by CBL", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-BTA-110312:r:Translesion synthesis by REV1", "R-CFA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-CFA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-9648002:r:RAS processing", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CFA-9766229:r:Degradation of CDH1", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-8948747:r:Regulation of PTEN localization", "R-SSC-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5689877:r:Josephin domain DUBs", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SSC-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-909733:r:Interferon alpha/beta signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-SSC-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-CFA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CFA-5654726:r:Negative regulation of FGFR1 signaling", "R-CFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-CFA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CFA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-SSC-5689603:r:UCH proteinases", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-912631:r:Regulation of signaling by CBL", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-CFA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-RNO-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-201681:r:TCF dependent signaling in response to WNT", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-2559585:r:Oncogene Induced Senescence", "R-CEL-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-CFA-6807004:r:Negative regulation of MET activity", "R-DME-9664873:r:Pexophagy", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-CFA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-433871:r:TRAF6 mediated induction of proinflammatory cytokines", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-SSC-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CFA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-6782135:r:Dual incision in TC-NER", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-4641257:r:Degradation of AXIN", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-SSC-5656121:r:Translesion synthesis by POLI", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-CFA-2467813:r:Separation of Sister Chromatids", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-5689901:r:Metalloprotease DUBs", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CFA-209560:r:NF-kB is activated and signals survival", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-68949:r:Orc1 removal from chromatin", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-5689901:r:Metalloprotease DUBs", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-CFA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-9664873:r:Pexophagy", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-RNO-110312:r:Translesion synthesis by REV1", "R-SSC-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CFA-8951664:r:Neddylation", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-SSC-909733:r:Interferon alpha/beta signaling", "R-DME-912631:r:Regulation of signaling by CBL", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-SSC-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-CFA-5656121:r:Translesion synthesis by POLI", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-CFA-9648002:r:RAS processing", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-CFA-9932298:r:Degradation of CRY and PER proteins", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CFA-382556:r:ABC-family proteins mediated transport", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-4641258:r:Degradation of DVL", "R-CFA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-CFA-9758274:r:Regulation of NF-kappa B signaling", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-6807004:r:Negative regulation of MET activity", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-BTA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CFA-8948747:r:Regulation of PTEN localization", "R-CFA-937039:r:IRAK1 recruits IKK complex", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SSC-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9683683:r:Maturation of protein E", "R-SSC-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-69541:r:Stabilization of p53", "R-SSC-9664873:r:Pexophagy", "R-SSC-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CFA-8863795:r:Downregulation of ERBB2 signaling", "R-CFA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CFA-9861718:r:Regulation of pyruvate metabolism", "R-CFA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-CFA-5689603:r:UCH proteinases", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-182971:r:EGFR downregulation", "R-BTA-182971:r:EGFR downregulation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-CFA-5655862:r:Translesion synthesis by POLK", "R-CFA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-5654733:r:Negative regulation of FGFR4 signaling", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-917937:r:Iron uptake and transport", "R-SSC-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-CFA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CFA-205043:r:NRIF signals cell death from the 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"R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-CFA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SSC-202424:r:Downstream TCR signaling", "R-RNO-9770562:r:mRNA Polyadenylation", "R-SSC-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CFA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-SSC-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CEL-9020702:r:Interleukin-1 signaling", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CFA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-69231:r:Cyclin D associated events in G1", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5656121:r:Translesion synthesis by POLI", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-CFA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-9020702:r:Interleukin-1 signaling", "R-SSC-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-3322077:r:Glycogen synthesis", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-6783310:r:Fanconi Anemia Pathway", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DME-5689877:r:Josephin domain DUBs", "R-CFA-9020702:r:Interleukin-1 signaling", "R-HSA-110312:r:Translesion synthesis by REV1", "R-SSC-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CFA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-DDI-5689877:r:Josephin domain DUBs", "R-RNO-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5689901:r:Metalloprotease DUBs", "R-SSC-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-9770562:r:mRNA Polyadenylation", "R-SSC-8951664:r:Neddylation", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CFA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SSC-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-2672351:r:Stimuli-sensing channels", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CFA-110312:r:Translesion synthesis by REV1", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-CFA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-8948747:r:Regulation of PTEN localization", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-6807004:r:Negative regulation of MET activity", "R-DME-9033241:r:Peroxisomal protein import", "R-RNO-6782135:r:Dual incision in TC-NER", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-538864:r:Degradation of CRY", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-909733:r:Interferon 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domain DUBs", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SSC-110320:r:Translesion Synthesis by POLH", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-182971:r:EGFR downregulation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-SSC-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-DME-4641257:r:Degradation of AXIN", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-CFA-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of 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degradation of Securin", "R-CFA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-9648002:r:RAS processing", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-SSC-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-5654727:r:Negative regulation of FGFR2 signaling", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-CEL-5689901:r:Metalloprotease DUBs", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-SSC-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-SSC-9646399:r:Aggrephagy", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-9648002:r:RAS processing", "R-SSC-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-CEL-9646399:r:Aggrephagy", "R-CFA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-GGA-353303:r:Nucleotide Excision Repair", "R-CFA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CFA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-5689877:r:Josephin domain DUBs", "R-SSC-4641258:r:Degradation of DVL", "R-BTA-5689603:r:UCH proteinases", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-CFA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-CEL-4641257:r:Degradation of AXIN", "R-CFA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-CFA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-CFA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-69231:r:Cyclin D associated events in G1", "R-DDI-9033241:r:Peroxisomal protein import", "R-DME-6782135:r:Dual incision in TC-NER", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-CEL-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-5675482:r:Regulation of necroptotic cell death", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-8951664:r:Neddylation", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1236974:r:ER-Phagosome pathway", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9648002:r:RAS processing", "R-SSC-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-BTA-68949:r:Orc1 removal from chromatin", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2672351:r:Stimuli-sensing channels", "R-CFA-5632684:r:Hedgehog 'on' state", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-69541:r:Stabilization of p53", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SSC-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-SSC-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-912631:r:Regulation of signaling by CBL", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9706369:r:Negative regulation of FLT3", "R-DME-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-5696400:r:Dual Incision in GG-NER", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-9646399:r:Aggrephagy", "R-CFA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-182971:r:EGFR downregulation", "R-SSC-9033241:r:Peroxisomal protein import", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SSC-68867:r:Assembly of the pre-replicative complex", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-SSC-69481:r:G2/M Checkpoints", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-CFA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CFA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-SSC-9861718:r:Regulation of pyruvate metabolism", "R-SSC-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-CFA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-SSC-5689880:r:Ub-specific processing proteases", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CFA-202424:r:Downstream TCR signaling", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-CEL-6807004:r:Negative regulation of MET activity", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-8866427:r:VLDLR internalisation and degradation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-SSC-8948751:r:Regulation of PTEN stability and activity", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-5689901:r:Metalloprotease DUBs", "R-DME-5655862:r:Translesion synthesis by POLK", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-69481:r:G2/M Checkpoints", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-CFA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-9770562:r:mRNA Polyadenylation", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SSC-5358346:r:Hedgehog ligand biogenesis", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9706369:r:Negative regulation of FLT3", "R-CFA-68867:r:Assembly of the pre-replicative complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CFA-69231:r:Cyclin D associated events in G1", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-CEL-2672351:r:Stimuli-sensing channels", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-9020702:r:Interleukin-1 signaling", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-8948747:r:Regulation of PTEN localization", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-CFA-4641258:r:Degradation of DVL", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5689877:r:Josephin domain DUBs", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-9706369:r:Negative regulation of FLT3", "R-DDI-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-SSC-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-CFA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-4641257:r:Degradation of AXIN", "R-CFA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CFA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-977225:r:Amyloid fiber formation", "R-CFA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 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"R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DRE-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DRE-9932298:r:Degradation of CRY and PER proteins", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DRE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DRE-5632684:r:Hedgehog 'on' state", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-5632684:r:Hedgehog 'on' state", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9907900:r:Proteasome assembly", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-DRE-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C"], "type": "Homologous_superfamily"}, "IPR038634": {"description": "Alphacoronavirus 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exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Homologous_superfamily"}, "IPR038636": {"description": "Capsule assembly protein Wzi superfamily", "go_ids": [], "go_terms": [], "name": "Wzi_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038637": {"description": "NPCBM domain superfamily", "go_ids": [], "go_terms": [], "name": "NPCBM_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038638": {"description": "RbpA superfamily", "go_ids": [], "go_terms": [], "name": "RbpA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038639": {"description": "AlgX, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "AlgX_C_sf", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Homologous_superfamily"}, "IPR038640": {"description": "Benzylsuccinate synthase gamma subunit superfamily", "go_ids": [], "go_terms": [], "name": "BssC_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038641": {"description": "Csa superfamily", "go_ids": [], "go_terms": [], "name": "Csa_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038642": {"description": "VioE superfamily", "go_ids": [], "go_terms": [], "name": "VioE_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038643": {"description": "PliI superfamily", "go_ids": [], "go_terms": [], "name": "PliI_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038644": {"description": "CopK superfamily", "go_ids": [], "go_terms": [], "name": "CopK_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038645": {"description": "TTC5, OB fold domain superfamily", "go_ids": [], "go_terms": [], "name": "TTC5_OB_sf", "pathway_ids": ["R-HSA-6804760", "R-BTA-6804760", "R-MMU-6804760", "R-RNO-6804760"], "pathways": ["R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation"], "type": "Homologous_superfamily"}, "IPR038646": {"description": "Atu4866-like superfamily", "go_ids": [], "go_terms": [], "name": "Atu4866-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038647": {"description": "Cren7 superfamily", "go_ids": [], "go_terms": [], "name": "Cren7_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038648": {"description": "PHR domain superfamily", "go_ids": [], "go_terms": [], "name": "PHR_sf", "pathway_ids": ["R-MMU-8951664", "R-DRE-8951664", "R-HSA-983168", "R-MMU-983168", "R-HSA-8951664", "R-DRE-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8951664:r:Neddylation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Homologous_superfamily"}, "IPR038649": {"description": "Exonuclease I, SH3-like domain superfamily", "go_ids": [], "go_terms": [], "name": "EXOI_SH3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038650": {"description": "PADR1, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PADR1_C_dom_sf", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-MMU-2173795", "R-HSA-3108214", "R-HSA-192814", "R-RNO-5696395", "R-HSA-110362", "R-DRE-5696400", "R-RNO-5685939", "R-DME-5696395", "R-RNO-110362", "R-RNO-3108214", "R-DRE-5685939", "R-HSA-5685939", "R-DRE-5696394", "R-DME-5696394", "R-DRE-110362", "R-RNO-5696394", "R-DRE-5696395", "R-DRE-3108214", "R-MMU-5696395", "R-RNO-2173795", "R-MMU-110362", "R-DME-5696400", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-2173795", "R-HSA-5696394", "R-RNO-5696400", "R-MMU-5685939", "R-HSA-5696400", "R-MMU-5696394", "R-MMU-3108214", "R-CEL-5696394", "R-MMU-5696400"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-192814:r:vRNA Synthesis", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DRE-5696400:r:Dual Incision in GG-NER", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5696400:r:Dual Incision in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696400:r:Dual Incision in GG-NER"], "type": "Homologous_superfamily"}, "IPR038651": {"description": "Yeast killer toxin superfamily", "go_ids": [], "go_terms": [], "name": "Yeast_kill_tox_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038652": {"description": "Circovirus capsid superfamily", "go_ids": [], "go_terms": [], "name": "Circovirus_capsid_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038653": {"description": "Putative carbohydrate metabolism domain superfamily", "go_ids": [], "go_terms": [], "name": "Put_CMD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038654": {"description": "PINIT domain superfamily", "go_ids": [], "go_terms": [], "name": "PINIT_sf", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-HSA-4755510", "R-DRE-4085377", "R-DRE-3232142", "R-HSA-5693565", "R-RNO-3108214", "R-SCE-4085377", "R-MMU-69473", "R-MMU-5696395", "R-DRE-5693571", "R-MMU-4551638", "R-SPO-5696395", "R-HSA-5693607", "R-RNO-3232118", "R-MMU-3232118", "R-CEL-4551638", "R-HSA-4090294", "R-SPO-4085377", "R-SPO-3899300", "R-HSA-4551638", "R-RNO-4090294", "R-RNO-3899300", "R-CEL-4085377", "R-HSA-69473", "R-RNO-5696395", "R-CEL-3232118", "R-HSA-3232142", "R-CEL-4090294", "R-DRE-196791", "R-DRE-3232118", "R-CEL-5696395", "R-HSA-5696395", "R-MMU-196791", "R-HSA-3232118", "R-RNO-3232142", "R-DRE-5693565", "R-MMU-3108214", "R-MMU-5693571", "R-HSA-5617472", "R-SPO-3232118", "R-RNO-4615885", "R-DRE-5693607", "R-MMU-3232142", "R-HSA-3108214", "R-DRE-4615885", "R-CEL-3899300", "R-MMU-4615885", "R-MMU-5693565", "R-DRE-3108214", "R-MMU-4085377", "R-HSA-196791", "R-HSA-877312", "R-CEL-3232142", "R-CEL-3108214", "R-MMU-4090294", "R-HSA-4615885", "R-SCE-3232118", "R-MMU-877312", "R-MMU-5693607", "R-MMU-3899300", "R-DRE-4755510", "R-SPO-4551638", "R-HSA-4085377", "R-RNO-4755510", "R-DRE-3899300", "R-RNO-4551638", "R-HSA-5693571", "R-SCE-4551638", "R-DRE-4090294", "R-CEL-877312", "R-HSA-3899300", "R-MMU-4755510"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-HSA-4755510:r:SUMOylation 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"R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-CEL-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CEL-4090294:r:SUMOylation of intracellular receptors", "R-DRE-196791:r:Vitamin D (calciferol) metabolism", "R-DRE-3232118:r:SUMOylation of transcription factors", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-RNO-3232142:r:SUMOylation of 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"R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SCE-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-4090294:r:SUMOylation of intracellular receptors", "R-CEL-877312:r:Regulation of IFNG signaling", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-4755510:r:SUMOylation of immune response proteins"], "type": "Homologous_superfamily"}, "IPR038655": {"description": "Large ribosomal subunit protein eL27 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_eL27_sf", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-DRE-9954709", "R-RNO-1799339", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-MMU-6791226", 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"R-HSA-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Homologous_superfamily"}, "IPR038663": {"description": "Bacteriophage PRD1, P5 C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PRD1_P5_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038664": {"description": "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain", "go_ids": [], "go_terms": [], "name": "Gar1/Naf1_Cbf5-bd_sf", "pathway_ids": ["R-XTR-171319", "R-DRE-171319", "R-RNO-171319", "R-HSA-6790901", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-XTR-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Homologous_superfamily"}, "IPR038665": {"description": "Voltage-dependent anion channel 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[], "name": "HslJ-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038671": {"description": "Human cytomegalovirus, UL16 ectodomain", "go_ids": [], "go_terms": [], "name": "HCMV_UL16_sf", "pathway_ids": ["R-HSA-9609690"], "pathways": ["R-HSA-9609690:r:HCMV Early Events"], "type": "Homologous_superfamily"}, "IPR038672": {"description": "Chromophore lyase CpcT/CpeT superfamily", "go_ids": [], "go_terms": [], "name": "CpcT/CpeT_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038673": {"description": "Carbohydrate-selective porin OprB superfamily", "go_ids": [], "go_terms": [], "name": "OprB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038674": {"description": "CzcE superfamily", "go_ids": [], "go_terms": [], "name": "CzcE_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038676": {"description": "Photosystem II Psb28, class 1 superfamily", "go_ids": [], "go_terms": [], "name": "Psb28_c1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038677": {"description": "WIF domain superfamily", "go_ids": [], "go_terms": [], "name": "WIF_sf", "pathway_ids": ["R-CEL-201681", "R-HSA-3772470", "R-HSA-201681", "R-MMU-201681", "R-HSA-4086400", "R-DME-201681"], "pathways": ["R-CEL-201681:r:TCF dependent signaling in response to WNT", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-HSA-4086400:r:PCP/CE pathway", "R-DME-201681:r:TCF dependent signaling in response to WNT"], "type": "Homologous_superfamily"}, "IPR038678": {"description": "Spondin, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Spondin_N_sf", "pathway_ids": ["R-BTA-5173214", "R-RNO-5173214", "R-HSA-5173214", "R-HSA-5083635", "R-MMU-5173214"], "pathways": ["R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Homologous_superfamily"}, "IPR038679": {"description": "Signal transduction protein PmrD superfamily", "go_ids": [], "go_terms": [], "name": "PmrD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038680": {"description": "PAW domain superfamily", "go_ids": [], "go_terms": [], "name": "PAW_sf", "pathway_ids": ["R-HSA-532668", "R-MMU-532668", "R-CEL-532668", "R-DME-532668", "R-DRE-532668", "R-RNO-532668"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "type": "Homologous_superfamily"}, "IPR038681": {"description": "Sf6-type phage tail needle knob superfamily", "go_ids": [], "go_terms": [], "name": "Phage_tail_NK_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038682": {"description": "YrpD-like superfamily", "go_ids": [], "go_terms": [], "name": "YrpD-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038683": {"description": "Interleukin-17 receptor A/B, FnIII-like domain 1 superfamily", "go_ids": [], "go_terms": [], "name": "IL17RA/B_FnIII-like_1_sf", "pathway_ids": ["R-HSA-448424", "R-CEL-5674135", "R-HSA-9705671"], "pathways": ["R-HSA-448424:r:Interleukin-17 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses"], "type": "Homologous_superfamily"}, "IPR038685": {"description": "PAD, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PAD_N_sf", "pathway_ids": ["PWY-4921", "R-MMU-6798695", "R-HSA-6798695", "R-RNO-3247509", "R-RNO-6798695", "R-MMU-3247509", "R-HSA-3247509"], "pathways": ["PWY-4921:t:protein citrullination", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-HSA-3247509:r:Chromatin modifying enzymes"], "type": "Homologous_superfamily"}, "IPR038686": {"description": "MIC1, C-terminal superfamily", "go_ids": [], "go_terms": [], "name": "MIC1_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038687": {"description": "Apoptosis regulator, M-T4 superfamily", "go_ids": [], "go_terms": [], "name": "M-T4_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038688": {"description": "Flavivirus polyprotein propeptide superfamily", "go_ids": [], "go_terms": [], "name": "Flavi_propep_sf", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Homologous_superfamily"}, "IPR038689": {"description": "Thermostable direct haemolysin superfamily", "go_ids": [], "go_terms": [], "name": "TDH_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038690": {"description": "NusG, domain 2 superfamily", "go_ids": [], "go_terms": [], "name": "NusG_2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038691": {"description": "DNA-entry nuclease inhibitor, ComJ superfamily", "go_ids": [], "go_terms": [], "name": "ComJ_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038692": {"description": "Cthe_2751-like superfamily", "go_ids": [], "go_terms": [], "name": "Cthe_2751_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038693": {"description": "Phenylacetyl-CoA epoxidase, subunit B", "go_ids": [], "go_terms": [], "name": "PaaB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038694": {"description": "Superfamily of unknown function DUF427", "go_ids": [], "go_terms": [], "name": "DUF427_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038695": {"description": "Saro_0823-like superfamily", "go_ids": [], "go_terms": [], "name": "Saro_0823-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038696": {"description": "Invasion protein B superfamily", "go_ids": [], "go_terms": [], "name": "IalB_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038698": {"description": "Tp47, domain C superfamily", "go_ids": [], "go_terms": [], "name": "PBP_Tp47_domC_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038700": {"description": "Thiol-activated cytolysin, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Thiol_cytolys_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038701": {"description": "ToxA superfamily", "go_ids": [], "go_terms": [], "name": "ToxA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038702": {"description": "Sodium/potassium-transporting ATPase subunit beta superfamily", "go_ids": [], "go_terms": [], "name": "Na/K_ATPase_sub_beta_sf", "pathway_ids": ["R-MMU-2173795", "R-CEL-2173795", "R-CEL-210991", "R-RNO-210991", "R-DME-210991", "R-MMU-210991", "R-RNO-5578775", "R-SSC-2173795", "R-MMU-5578775", "R-HSA-936837", "R-HSA-9679191", "R-DME-2173795", "R-SSC-5578775", "R-BTA-936837", "R-RNO-936837", "R-CEL-936837", "R-SSC-936837", "R-CFA-936837", "R-RNO-2173795", "R-HSA-2173795", "R-BTA-5578775", "R-HSA-5578775", "R-GGA-2173795", "R-BTA-2173795", "R-MMU-936837", "R-HSA-210991"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-210991:r:Basigin interactions", "R-RNO-210991:r:Basigin interactions", "R-DME-210991:r:Basigin interactions", "R-MMU-210991:r:Basigin interactions", "R-RNO-5578775:r:Ion homeostasis", "R-SSC-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-5578775:r:Ion homeostasis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-SSC-936837:r:Ion transport by P-type ATPases", "R-CFA-936837:r:Ion transport by P-type ATPases", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-HSA-210991:r:Basigin interactions"], "type": "Homologous_superfamily"}, "IPR038703": {"description": "YebF/Cmi superfamily", "go_ids": [], "go_terms": [], "name": "YebF/Cmi_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038704": {"description": "YEATS superfamily", "go_ids": [], "go_terms": [], "name": "YEAST_sf", "pathway_ids": ["R-HSA-8866907", "R-HSA-75955", "R-HSA-9772755", "R-MMU-674695", "R-MMU-8866907", "R-HSA-3214847", "R-MMU-9772755", "R-HSA-674695", "R-MMU-75955", "R-HSA-112382", "R-MMU-112382"], "pathways": ["R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-112382:r:Formation of RNA Pol II elongation complex"], "type": "Homologous_superfamily"}, "IPR038705": {"description": "YabP superfamily", "go_ids": [], "go_terms": [], "name": "YabP_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038706": {"description": "Type VI secretion protein SciN-like superfamily", "go_ids": [], "go_terms": [], "name": "Type_VI_SciN-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038707": {"description": "Conjugal transfer protein TraQ superfamily", "go_ids": [], "go_terms": [], "name": "TraQ_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038708": {"description": "Gp34-like superfamily", "go_ids": [], "go_terms": [], "name": "Gp34-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038709": {"description": "RNA polymerase sigma-54 factor, core-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "RpoN_core-bd_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038710": {"description": "Adenovirus Gp19K superfamily", "go_ids": [], "go_terms": [], "name": "Adenovirus_Gp19K_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038711": {"description": "Leucine Rich repeat protein, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "LRR_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038712": {"description": "PixA-like superfamily", "go_ids": [], "go_terms": [], "name": "PixA-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038713": {"description": "Terminase small subunit, N-terminal DNA-binding domain, HTH motif superfamily", "go_ids": [], "go_terms": [], "name": "Terminase_Gp1_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038714": {"description": "YfeY-like superfamily", "go_ids": [], "go_terms": [], "name": "YfeY-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038715": {"description": "RNA polymerase inhibitor superfamily", "go_ids": [], "go_terms": [], "name": "RNA_pol_inhibitor_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038716": {"description": "Large ribosomal subunit protein P1/P2, N-terminal domain", "go_ids": [], 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"R-MMU-9954709", "R-HSA-192823", "R-PFA-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-PFA-72706", "R-SPO-1799339", "R-SCE-1799339", "R-DME-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-PFA-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-PFA-9954714"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-PFA-72689:r:Formation of a pool of free 40S subunits", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", 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enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-PFA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-PFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated 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"Homologous_superfamily"}, "IPR038717": {"description": "Tc1-like transposase, DDE domain", "go_ids": [], "go_terms": [], "name": "Tc1-like_DDE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR038718": {"description": "SNF2-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "SNF2-like_sf", "pathway_ids": ["PWY-7250", "R-MMU-9933946", "R-MMU-1266695", "R-HSA-427413", "R-MMU-3214815", "R-BTA-201722", "R-MMU-606279", "R-HSA-5693565", "R-DRE-2467813", "R-BTA-9933946", "R-BTA-3247509", "R-MMU-68877", "R-MMU-2559584", "R-SPO-6781823", "R-DME-5696394", "R-DME-9933939", "R-HSA-9844594", "R-BTA-2500257", "R-DME-9764725", "R-MMU-5696394", "R-DRE-5663220", "R-MMU-8866654", "R-DRE-3769402", "R-MMU-9934037", "R-CEL-9933937", "R-HSA-3247509", "R-HSA-141444", "R-HSA-9670615", "R-RNO-9934037", "R-HSA-9764725", "R-RNO-9933947", "R-MMU-9031628", "R-HSA-8866654", "R-MMU-9933939", "R-RNO-9764725", "R-HSA-9933937", "R-HSA-9670095", "R-HSA-5696395", "R-BTA-8939243", "R-DME-3247509", "R-MMU-6804758", "R-HSA-9670613", "R-HSA-5696394", "R-HSA-9031628", "R-BTA-9648025", "R-CEL-9031628", "R-MMU-5663220", "R-DME-9933946", "R-HSA-6781827", "R-HSA-2467813", "R-DRE-5696400", "R-BTA-9764725", "R-CEL-9934037", "R-DME-9934037", "R-HSA-9934037", "R-DME-3214815", "R-MMU-5693565", "R-BTA-1266695", "R-MMU-6781823", "R-DME-3214858", "R-HSA-68877", "R-HSA-6782210", "R-HSA-2559584", "R-DME-9031628", "R-BTA-5696400", "R-MMU-5696400", "R-RNO-9933946", "R-HSA-9839394", "R-HSA-381340", "R-SCE-6781823", "R-HSA-9707616", "R-MMU-3214858", "R-MMU-8943724", "R-BTA-9934037", "R-HSA-201722", "R-SPO-6782210", "R-HSA-427389", "R-HSA-5663220", "R-HSA-5696400", "R-HSA-3214847", "R-RNO-3247509", "R-RNO-3769402", "R-HSA-2426168", "R-MMU-9707564", "R-HSA-1989781", "R-DME-9933947", "R-HSA-2151201", "R-RNO-3214858", "R-MMU-2467813", "R-MMU-201722", "R-DRE-141444", "R-HSA-1368108", "R-RNO-8939243", "R-HSA-6781823", "R-MMU-5696395", "R-DME-1266695", "R-HSA-9933387", "R-HSA-8943724", "R-CEL-4551638", "R-HSA-9707564", "R-MMU-3247509", "R-DME-6804758", "R-HSA-4551638", "R-HSA-9018519", "R-HSA-1266695", "R-HSA-606279", "R-MMU-5250924", "R-MMU-141444", "R-MMU-2559586", "R-HSA-9933947", "R-HSA-3214815", "R-HSA-9648025", "R-RNO-9933937", "R-HSA-8939243", "R-HSA-400206", "R-MMU-6782210", "R-HSA-5689603", "R-HSA-2559586", "R-DME-8943724", "R-MMU-400206", "R-SCE-6782135", "R-CEL-9933947", "R-HSA-9818027", "R-MMU-73762", "R-DME-8939243", "R-HSA-3769402", "R-MMU-6782135", "R-RNO-201722", "R-MMU-9933937", "R-HSA-9619665", "R-BTA-5663220", "R-HSA-3214858", "R-BTA-9933937", "R-MMU-9670095", "R-BTA-3214858", "R-HSA-6804758", "R-DRE-5696395", "R-BTA-2467813", "R-CEL-8943724", "R-HSA-9845323", "R-DME-5689603", "R-DME-9933937", "R-BTA-9933939", "R-CEL-9933946", "R-BTA-5696395", "R-MMU-5689603", "R-RNO-9933939", "R-SCE-6782210", "R-MMU-9648025", "R-HSA-9931509", "R-MMU-3769402", "R-MMU-2500257", "R-RNO-1266695", "R-HSA-2500257", "R-DRE-2500257", "R-BTA-9933947", "R-HSA-9933939", 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"R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-3247509:r:Chromatin modifying enzymes", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-1266695:r:Interleukin-7 signaling", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-3247509:r:Chromatin modifying enzymes", "R-DME-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5689603:r:UCH proteinases", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", 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"R-CEL-3214858:r:RMTs methylate histone arginines", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Homologous_superfamily"}, "IPR038719": {"description": "Phycobilisome, alpha/beta subunit superfamily", "go_ids": [], "go_terms": [], "name": "Phycobilisome_asu/bsu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR038720": {"description": "MrfB-like, ribonuclease H-like domain", "go_ids": [], "go_terms": [], "name": "MrfB-like_RNase_H-like_dom", "pathway_ids": [], 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["R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR038727": {"description": "NadR/Ttd14, AAA domain", "go_ids": [], "go_terms": [], "name": "NadR/Ttd14_AAA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR038728": {"description": "Uncharacterized membrane protein YkvI-like", "go_ids": [], "go_terms": [], "name": "YkvI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038729": {"description": "Rad50/SbcC-type AAA domain", "go_ids": ["GO:0016887", "GO:0006302"], "go_terms": ["GO:0016887:ATP hydrolysis activity:F", "GO:0006302:double-strand break repair:P"], "name": "Rad50/SbcC_AAA", "pathway_ids": ["R-SCE-3108214", "R-HSA-3108214", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5693565", "R-SCE-2559586", "R-MMU-6804756", "R-DDI-2559586", "R-RNO-5685939", "R-HSA-5693565", "R-MMU-5693616", "R-RNO-5693548", "R-DME-5693565", "R-HSA-2559586", "R-MMU-5685938", "R-DDI-5693565", "R-MMU-5693565", "R-MMU-69473", 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"PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR038732": {"description": "FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like, FAD/NAD(P)-binding domain", "go_ids": [], "go_terms": [], "name": "HpyO/CreE_NAD-binding", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR038733": {"description": "Predicted DNA-binding protein, ribbon-helix-helix domain", "go_ids": [], "go_terms": [], "name": "Predicted_DNA_bind_prot_RHH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR038734": {"description": "YhaN, AAA domain", "go_ids": [], "go_terms": [], "name": "YhaN_AAA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR038737": {"description": "Splicing factor 3B subunit 1-like", "go_ids": ["GO:0003729", "GO:0000245"], "go_terms": ["GO:0003729:mRNA binding:F", "GO:0000245:spliceosomal complex assembly:P"], "name": "SF3b_su1-like", "pathway_ids": ["R-HSA-72163", "R-SPO-9770562", "R-MMU-5250924", "R-HSA-9770562", "R-MMU-72165", "R-MMU-9770562", "R-MMU-72163", "R-HSA-5250924", "R-HSA-72165", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR038739": {"description": "Armadillo-type fold containing protein ARMC8/Vid28", "go_ids": [], "go_terms": [], "name": "ARMC8/Vid28", "pathway_ids": ["R-DRE-9861718", "R-HSA-6798695", "R-SPO-6798695", "R-DRE-6798695", "R-MMU-9861718", "R-SCE-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-BTA-9861718", "R-HSA-9861718"], "pathways": ["R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism"], "type": "Family"}, "IPR038740": {"description": "BioF2-like, acetyltransferase domain", "go_ids": [], "go_terms": [], "name": "BioF2-like_GNAT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR038741": {"description": "AP-5 complex subunit beta-1", "go_ids": ["GO:0016197"], "go_terms": ["GO:0016197:endosomal transport:P"], "name": "AP5B1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038746": {"description": "Alpha-tubulin N-acetyltransferase", "go_ids": ["GO:0019799"], "go_terms": ["GO:0019799:tubulin N-acetyltransferase activity:F"], "name": "Atat", "pathway_ids": ["R-MMU-5620920", "R-RNO-5620920", "R-HSA-5620920"], "pathways": ["R-MMU-5620920:r:Cargo trafficking to the periciliary membrane", "R-RNO-5620920:r:Cargo trafficking to the periciliary membrane", "R-HSA-5620920:r:Cargo trafficking to the periciliary membrane"], "type": "Family"}, "IPR038747": {"description": "Stannin", "go_ids": [], "go_terms": [], "name": "Stannin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038750": {"description": "Uncharacterized protein YczE/YyaS-like", "go_ids": [], "go_terms": [], "name": "YczE/YyaS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038751": {"description": "INTS8", "go_ids": ["GO:0034472"], "go_terms": ["GO:0034472:snRNA 3'-end processing:P"], "name": "INTS8", "pathway_ids": ["R-DME-6807505", "R-MMU-6807505", "R-HSA-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR038752": {"description": "IQ domain-containing protein H", "go_ids": [], "go_terms": [], "name": "IQCH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038753": {"description": "NF-kappa-B inhibitor-like protein 1", "go_ids": ["GO:0043124"], "go_terms": ["GO:0043124:negative regulation of canonical NF-kappaB signal transduction:P"], "name": "NFKBIL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038754": {"description": "Testis-expressed basic protein 1", "go_ids": [], "go_terms": [], "name": "TSBP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038756": {"description": "CheY-P phosphatase CheX-like", "go_ids": [], "go_terms": [], "name": "CheX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038757": {"description": "Bombesin receptor-activated protein", "go_ids": [], "go_terms": [], "name": "BRAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038759": {"description": "HSPRO1/HSPRO2", "go_ids": [], "go_terms": [], "name": "HSPRO1/HSPRO2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038760": {"description": "Photosystem II PsbY, plant", "go_ids": ["GO:0009523"], "go_terms": ["GO:0009523:photosystem II:C"], "name": "PsbY_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038762": {"description": "Antibiotic biosynthesis monooxygenase, predicted", "go_ids": [], "go_terms": [], "name": "ABM_predict", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038763": {"description": "DHH phosphoesterase superfamily", "go_ids": [], "go_terms": [], "name": "DHH_sf", "pathway_ids": ["PWY-7807", "PWY-7805"], "pathways": ["PWY-7807:t:glyphosate degradation III", "PWY-7805:t:(aminomethyl)phosphonate degradation"], "type": "Homologous_superfamily"}, "IPR038764": {"description": "GNAT family N-acetyltransferase, predicted", "go_ids": [], "go_terms": [], "name": "GNAT_N_AcTrfase_prd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038765": {"description": "Papain-like cysteine peptidase superfamily", "go_ids": [], "go_terms": [], "name": "Papain-like_cys_pep_sf", "pathway_ids": ["R-SSC-5689603", "R-BTA-5689880", "R-SPO-5656169", "R-BTA-5357786", "R-HSA-8951664", "R-MMU-1632852", "R-HSA-9010553", "R-HSA-3065679", "R-RNO-110314", "R-MMU-8948751", "R-CEL-532668", "R-DME-5696394", "R-MMU-110314", "R-SPO-5689880", "R-MMU-5689880", "R-SSC-2132295", "R-SCE-6791226", "R-PFA-2132295", "R-DME-9664873", "R-MMU-5696394", "R-CFA-2132295", "R-SCE-5689880", "R-DDI-6798695", "R-CFA-1632852", "R-MMU-9035034", "R-HSA-532668", "R-DRE-8948751", "R-MMU-380259", "R-SSC-1592389", "R-MMU-1592389", "R-GGA-8948751", "R-HSA-432720", "R-HSA-9758274", "R-MMU-8948747", "R-DRE-380320", "R-MMU-201681", "R-DME-1592389", "R-CEL-5683826", "R-XTR-380320", "R-BTA-1632852", "R-SCE-1632852", "R-RNO-6804757", "R-HSA-72163", "R-CEL-6782135", "R-MMU-5357905", "R-RNO-936440", "R-SPO-8951664", "R-MMU-3108214", "R-MMU-9766229", "R-SCE-429947", "R-HSA-201681", "R-SSC-6798695", "R-SCE-5689896", "R-HSA-156582", "R-HSA-8862803", "R-MMU-5357956", "R-GGA-1483101", "R-DRE-532668", "R-RNO-9860927", "R-MMU-5693565", "R-HSA-446193", "R-BTA-9010553", "R-HSA-114608", "R-RNO-3065679", "R-BTA-936440", "R-MMU-429947", "R-MMU-2132295", "R-HSA-2173795", "R-SSC-8939242", "R-HSA-6782210", "R-SSC-1442490", "R-DDI-5689880", "R-RNO-2132295", "R-BTA-432720", "R-HSA-4641263", "R-DME-6798695", "R-MMU-5656169", "R-MMU-9013424", "R-RNO-2022377", "R-DME-5696395", "R-DME-2173795", "R-HSA-6807004", "R-DME-2022090", "R-HSA-1358803", "R-HSA-140875", "R-MMU-2022090", "R-MMU-6783310", "R-GGA-5689880", "R-HSA-5357956", "R-SPO-6782210", "R-DME-1442490", "R-HSA-3214847", "R-DME-6782210", "R-RNO-5357786", "R-HSA-2173788", "R-BTA-5357905", "R-DME-5689880", "R-RNO-156582", "R-HSA-6798695", "R-CFA-1234158", "R-CEL-8948747", "R-SCE-5689603", "R-MMU-4641263", "R-MMU-2024096", "R-HSA-5689896", "R-MMU-5694530", "R-CEL-6798695", "R-BTA-6798695", "R-RNO-5357905", "R-SSC-1474228", "R-SPO-9664873", "R-MMU-2565942", "R-HSA-5694530", "R-RNO-2024096", "R-DDI-5693565", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-8951664", "R-MMU-5696395", "R-SPO-5696395", "R-BTA-9758274", "R-MMU-445989", "R-CEL-5689603", "R-HSA-9678110", "R-XTR-1632852", "R-HSA-6804757", "R-CEL-204005", "R-DRE-1632852", "R-DME-8948747", "R-BTA-204005", "R-XTR-5689880", "R-MMU-1474228", "R-RNO-6782210", "R-DDI-5683826", "R-RNO-432720", "R-RNO-8939242", "R-DDI-8948751", "R-HSA-9694614", "R-XTR-380259", "R-HSA-5357786", "R-SPO-5689603", "R-CEL-6781823", "R-HSA-204005", "R-BTA-1592389", "R-MMU-6809371", "R-BTA-8866652", "R-CFA-1474228", "R-SSC-1632852", "R-DME-8939242", "R-CFA-8939242", "R-HSA-1632852", "R-MMU-8854518", "R-MMU-6798695", "R-MMU-3065679", "R-RNO-168638", "R-HSA-8939242", "R-SPO-1632852", "R-CEL-5689896", "R-DDI-8866652", "R-SCE-6782135", "R-MMU-114608", "R-HSA-2132295", "R-HSA-6809371", "R-MMU-9856530", "R-HSA-3108214", "R-MMU-9648002", "R-BTA-1442490", "R-HSA-977225", "R-HSA-5633231", "R-GGA-156582", "R-DME-9013424", "R-RNO-114608", "R-CFA-5689880", "R-DRE-5696395", "R-HSA-2565942", "R-RNO-5689603", "R-CFA-2022090", "R-HSA-9035034", "R-HSA-2024096", "R-DME-5689603", "R-DRE-5689896", "R-MMU-168638", "R-SCE-983168", "R-MMU-5683826", "R-DME-2024096", "R-BTA-8948751", "R-DME-9758274", "R-XTR-380284", "R-HSA-9753281", "R-MMU-9033241", "R-RNO-5683826", "R-HSA-983168", "R-RNO-1442490", "R-BTA-156582", "R-MMU-1169408", "R-BTA-5689603", "R-BTA-9860927", "R-CEL-1169408", "R-CFA-8937144", "R-PFA-6798695", "R-RNO-9766229", "R-SPO-6782135", "R-HSA-380259", "R-MMU-912694", "R-HSA-9033241", "R-BTA-8939242", "R-DDI-2132295", "R-XTR-5689603", "R-MMU-2173795", "R-RNO-6781823", "R-BTA-1679131", "R-DDI-5689896", "R-MMU-9753281", "R-SSC-1679131", "R-RNO-2022090", "R-HSA-168638", "R-RNO-9753281", "R-HSA-5689880", "R-RNO-1474228", "R-RNO-5693565", "R-RNO-140875", "R-HSA-5693565", "R-MMU-8866652", "R-DDI-114608", "R-MMU-5689896", "R-CEL-2132295", "R-MMU-380320", "R-DME-5689896", "R-RNO-1632852", "R-MMU-9013420", "R-SCE-3065679", "R-RNO-5656169", "R-DME-73856", "R-MMU-5620912", "R-DME-6782135", "R-HSA-1474228", "R-MMU-1679131", "R-MMU-6791226", "R-CEL-5694530", "R-MMU-72163", "R-BTA-1474228", "R-HSA-429947", "R-DME-114608", "R-SPO-5696394", "R-MMU-380270", "R-CEL-6782210", "R-PFA-5689603", "R-HSA-9609690", "R-HSA-2022377", "R-HSA-6783310", "R-RNO-5689880", "R-DME-9648002", "R-DRE-5689603", "R-SCE-8951664", "R-HSA-2022090", "R-RNO-8951664", "R-HSA-5696395", "R-GGA-9753281", "R-HSA-5696394", "R-HSA-9648002", "R-PFA-8951664", "R-MMU-9860927", "R-RNO-6798695", "R-HSA-9664873", "R-SCE-3108214", "R-GGA-983168", "R-HSA-6781827", "R-DME-429947", "R-BTA-5357956", "R-CFA-9768919", "R-CEL-432720", "R-DDI-6791226", "R-RNO-8866652", "R-MMU-380284", "R-MMU-8939242", "R-DME-8866652", "R-MMU-9664873", "R-MMU-6781823", "R-HSA-5357905", "R-DDI-5689603", "R-MMU-532668", "R-BTA-2132295", "R-CFA-211976", "R-HSA-1442490", "R-CEL-9013423", "R-RNO-5694530", "R-DDI-1632852", "R-RNO-9664873", "R-RNO-1592389", "R-CFA-1592389", "R-BTA-2022377", "R-MMU-6804757", "R-HSA-380270", "R-HSA-1236977", "R-MMU-140875", "R-DME-1474228", "R-CEL-5689880", "R-RNO-9856530", "R-DME-445989", "R-MMU-6807004", "R-BTA-5683826", "R-HSA-9856530", "R-SPO-3065679", "R-BTA-9753281", "R-XTR-8854518", "R-BTA-9856530", "R-RNO-6783310", "R-DME-9013420", "R-MMU-204005", "R-DME-6781823", "R-DME-8951664", "R-PFA-8866652", "R-HSA-9766229", "R-HSA-380284", "R-HSA-9013424", "R-HSA-8854518", "R-CEL-9035034", "R-HSA-380320", "R-RNO-1679131", "R-HSA-8866652", "R-SCE-9664873", "R-CEL-6791226", "R-DDI-3065679", "R-MMU-2022377", "R-HSA-9610379", "R-HSA-6785807", "R-RNO-429947", "R-BTA-5694530", "R-HSA-5683826", "R-RNO-532668", "R-HSA-6791226", "R-HSA-8948751", "R-HSA-5689603", "R-HSA-9860927", "R-RNO-5689896", "R-CEL-6809371", "R-RNO-983168", "R-MMU-6782210", "R-SPO-429947", "R-HSA-110314", "R-HSA-445989", "R-BTA-8951664", "R-DME-6804757", "R-MMU-6782135", "R-CEL-1632852", "R-DME-159236", "R-MMU-9010553", "R-MMU-156582", "R-XTR-380270", "R-HSA-936440", "R-HSA-1169408", "R-XTR-5620912", "R-HSA-912694", "R-SPO-5689896", "R-MMU-5689603", "R-MMU-432720", "R-SCE-6782210", "R-HSA-5656169", "R-BTA-168638", "R-HSA-5620912", "R-MMU-1358803", "R-MMU-1442490", "R-RNO-8948747", "R-GGA-429947", "R-DRE-5689880", "R-MMU-5357786", "R-RNO-6809371", "R-SPO-3108214", "R-BTA-5689896", "R-HSA-9013420", "R-HSA-390471", "R-HSA-8948747", "R-DME-9033241", "R-RNO-6782135", "R-HSA-6782135", "R-HSA-1592389", "R-DME-532668", "R-RNO-204005", "R-HSA-1679131", "R-PFA-114608", "R-SSC-6809371", "R-CFA-1679131", "R-XTR-2565942", "R-DME-2132295", "R-MMU-983168", "R-RNO-5357956", "R-MMU-936440", "R-CEL-3065679", "R-MMU-9758274", "R-SSC-5683826", "R-SPO-6791226"], "pathways": ["R-SSC-5689603:r:UCH proteinases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-8951664:r:Neddylation", "R-MMU-1632852:r:Macroautophagy", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-3065679:r:SUMO is proteolytically processed", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SSC-2132295:r:MHC class II antigen presentation", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-PFA-2132295:r:MHC class II antigen presentation", "R-DME-9664873:r:Pexophagy", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CFA-2132295:r:MHC class II antigen presentation", "R-SCE-5689880:r:Ub-specific processing proteases", "R-DDI-6798695:r:Neutrophil degranulation", "R-CFA-1632852:r:Macroautophagy", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-SSC-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-DME-1592389:r:Activation of Matrix Metalloproteinases", "R-CEL-5683826:r:Surfactant metabolism", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-1632852:r:Macroautophagy", "R-SCE-1632852:r:Macroautophagy", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-SPO-8951664:r:Neddylation", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-9766229:r:Degradation of CDH1", "R-SCE-429947:r:Deadenylation of mRNA", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-SSC-6798695:r:Neutrophil degranulation", "R-SCE-5689896:r:Ovarian tumor domain proteases", "R-HSA-156582:r:Acetylation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-GGA-1483101:r:Synthesis of PS", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-BTA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-114608:r:Platelet degranulation", "R-RNO-3065679:r:SUMO is proteolytically processed", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-429947:r:Deadenylation of mRNA", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SSC-1442490:r:Collagen degradation", "R-DDI-5689880:r:Ub-specific processing proteases", "R-RNO-2132295:r:MHC class II antigen presentation", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DME-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-GGA-5689880:r:Ub-specific processing proteases", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-1442490:r:Collagen degradation", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-DME-5689880:r:Ub-specific processing proteases", "R-RNO-156582:r:Acetylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-CFA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-CEL-8948747:r:Regulation of PTEN localization", "R-SCE-5689603:r:UCH proteinases", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-2024096:r:HS-GAG degradation", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-MMU-5694530:r:Cargo concentration in the ER", "R-CEL-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-SPO-9664873:r:Pexophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-2024096:r:HS-GAG degradation", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-5689603:r:UCH proteinases", "R-HSA-9678110:r:Attachment and Entry", "R-XTR-1632852:r:Macroautophagy", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-DRE-1632852:r:Macroautophagy", "R-DME-8948747:r:Regulation of PTEN localization", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-XTR-5689880:r:Ub-specific processing proteases", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-5683826:r:Surfactant metabolism", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9694614:r:Attachment and Entry", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-SPO-5689603:r:UCH proteinases", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-BTA-1592389:r:Activation of Matrix Metalloproteinases", "R-MMU-6809371:r:Formation of the cornified envelope", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-SSC-1632852:r:Macroautophagy", "R-DME-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-CFA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-1632852:r:Macroautophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-3065679:r:SUMO is proteolytically processed", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-SPO-1632852:r:Macroautophagy", "R-CEL-5689896:r:Ovarian tumor domain proteases", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-114608:r:Platelet degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-9648002:r:RAS processing", "R-BTA-1442490:r:Collagen degradation", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-5633231:r:Defective ALG14 causes ALG14-CMS", "R-GGA-156582:r:Acetylation", "R-DME-9013424:r:RHOV GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-CFA-5689880:r:Ub-specific processing proteases", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-5689603:r:UCH proteinases", "R-CFA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-2024096:r:HS-GAG degradation", "R-DME-5689603:r:UCH proteinases", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SCE-983168:r:Antigen processing: Ubiquitination & 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"R-HSA-9662834", "R-DRE-2559580", "R-HSA-432142", "R-MMU-6804756", "R-CFA-69601", "R-RNO-69601", "R-MMU-4420097", "R-DRE-450302", "R-RNO-525793", "R-MMU-69601", "R-MMU-432142", "R-RNO-5668599", "R-HSA-4420097", "R-DRE-450341", "R-HSA-450341", "R-DRE-9824585", "R-CFA-5668599", "R-MMU-9824585", "R-DRE-6798695", "R-HSA-450302", "R-MMU-5668599", "R-CFA-418592", "R-CFA-168638", "R-RNO-6804756", "R-CFA-525793", "R-MMU-168638", "R-DRE-198753", "R-DRE-168638", "R-HSA-525793", "R-DRE-5668599", "R-HSA-171007", "R-HSA-198753", "R-DRE-6804756", "R-RNO-171007", "R-HSA-418592", "R-DRE-432142", "R-CFA-4420097", "R-DRE-69601", "R-CFA-9824585", "R-HSA-69601", "R-CFA-432142", "R-HSA-2151209", "R-MMU-2559580", "R-HSA-9824585", "R-MMU-418592", "R-MMU-171007", "R-RNO-2559580", "R-HSA-6804756", "R-CFA-198753", "R-DRE-418592", "R-RNO-450302", "R-HSA-450604", "R-MMU-450341", "R-MMU-6798695", "R-MMU-198753", "R-MMU-525793", "R-RNO-168638", "R-CFA-6798695", "R-RNO-198753", "R-RNO-450341", "R-DRE-4420097", "R-DRE-525793", "R-HSA-5668599", "R-RNO-4420097", "R-RNO-432142", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DRE-171007:r:p38MAPK events", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-CFA-450341:r:Activation of the AP-1 family of transcription factors", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-432142:r:Platelet sensitization by LDL", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-525793:r:Myogenesis", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-450341:r:Activation of the AP-1 family of transcription factors", "R-DRE-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-CFA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CFA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-525793:r:Myogenesis", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-DRE-198753:r:ERK/MAPK targets", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-HSA-525793:r:Myogenesis", "R-DRE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-171007:r:p38MAPK events", "R-HSA-198753:r:ERK/MAPK targets", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-171007:r:p38MAPK events", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DRE-432142:r:Platelet sensitization by LDL", "R-CFA-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CFA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CFA-432142:r:Platelet sensitization by LDL", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-171007:r:p38MAPK events", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-198753:r:ERK/MAPK targets", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-450341:r:Activation of the AP-1 family of transcription factors", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-198753:r:ERK/MAPK targets", "R-MMU-525793:r:Myogenesis", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-CFA-6798695:r:Neutrophil degranulation", "R-RNO-198753:r:ERK/MAPK targets", "R-RNO-450341:r:Activation of the AP-1 family of transcription factors", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-DRE-525793:r:Myogenesis", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-432142:r:Platelet sensitization by LDL", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR038788": {"description": "Testis-expressed protein 46-like", "go_ids": [], "go_terms": [], "name": "TEX46-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038789": {"description": "Protein LOW PSII ACCUMULATION 2", "go_ids": [], "go_terms": [], "name": "LPA2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038790": {"description": "Mediator of RNA polymerase II transcription subunit 9, plant", "go_ids": ["GO:0016592"], "go_terms": ["GO:0016592:mediator complex:C"], "name": "Med9_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038791": {"description": "Cilia- and flagella-associated protein 97", "go_ids": [], "go_terms": [], "name": "Cfap97/Hemingway", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038792": {"description": "CFAP97 domain-containing protein 1/2", "go_ids": [], "go_terms": [], "name": "CFAP97D1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038793": {"description": "Lysine-rich arabinogalactan protein 19", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "AGP19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038794": {"description": "Protein LIAT1", "go_ids": ["GO:0016598"], "go_terms": ["GO:0016598:protein arginylation:P"], "name": "LIAT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038795": {"description": "Mediator of RNA polymerase II transcription subunit 8, plant", "go_ids": ["GO:0016592"], "go_terms": ["GO:0016592:mediator complex:C"], "name": "MED8_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038796": {"description": "At1g76070-like", "go_ids": [], "go_terms": [], "name": "At1g76070-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038797": {"description": "Protein Flattop", "go_ids": [], "go_terms": [], "name": "Fltp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038798": {"description": "Coiled-coil domain-containing protein 138", "go_ids": [], "go_terms": [], "name": "CCDC138", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038799": {"description": "Protein LEKR1", "go_ids": [], "go_terms": [], "name": "LEKR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038800": {"description": "Coiled-coil domain-containing protein 17", "go_ids": [], "go_terms": [], "name": "CCDC17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038801": {"description": "TATA box-binding protein-associated factor RNA polymerase I subunit C", "go_ids": ["GO:0006360"], "go_terms": ["GO:0006360:transcription by RNA polymerase I:P"], "name": "TAF1C", "pathway_ids": ["R-HSA-73772", "R-HSA-73863", "R-MMU-5250924", "R-MMU-73762", "R-HSA-427359", "R-RNO-73772", "R-HSA-427413", "R-HSA-5250924", "R-MMU-73863", "R-MMU-73772", "R-RNO-5250924", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Family"}, "IPR038803": {"description": "Small integral membrane protein 33", "go_ids": [], "go_terms": [], "name": "SMIM33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038804": {"description": "Root meristem growth factor 3", "go_ids": ["GO:0008083", "GO:0010082"], "go_terms": ["GO:0008083:growth factor activity:F", "GO:0010082:regulation of root meristem growth:P"], "name": "RGF3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038805": {"description": "Transmembrane protein 139", "go_ids": [], "go_terms": [], "name": "TMEM139", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038806": {"description": "Spermatogenesis-associated protein 45, mammals", "go_ids": [], "go_terms": [], "name": "SPATA45_mammals", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038807": {"description": "Coiled-coil domain-containing protein 150", "go_ids": [], "go_terms": [], "name": "CCDC150", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038808": {"description": "Protein modifier of SNC1 1-like", "go_ids": [], "go_terms": [], "name": "MOS1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038810": {"description": "Centlein", "go_ids": [], "go_terms": [], "name": "CNTLN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038811": {"description": "CUB domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "CDCP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038813": {"description": "Fertilization-influencing membrane protein", "go_ids": ["GO:0007342"], "go_terms": ["GO:0007342:fusion of sperm to egg plasma membrane involved in single fertilization:P"], "name": "FIMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038814": {"description": "Altered inheritance of mitochondria protein 11", "go_ids": [], "go_terms": [], "name": "AIM11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038815": {"description": "IgA-inducing protein", "go_ids": [], "go_terms": [], "name": "IGIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038816": {"description": "Stationary phase protein 5", "go_ids": ["GO:0070628"], "go_terms": ["GO:0070628:proteasome binding:F"], "name": "Stationary_phase_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038817": {"description": "Coiled-coil domain-containing protein 192", "go_ids": [], "go_terms": [], "name": "CCDC192", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038818": {"description": "Mast cell-expressed membrane protein 1", "go_ids": [], "go_terms": [], "name": "MCEMP1", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR038820": {"description": "Coiled-coil domain-containing protein 171", "go_ids": [], "go_terms": [], "name": "CCDC171", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038821": {"description": "CLE-related protein 45-like", "go_ids": [], "go_terms": [], "name": "CLE45-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038822": {"description": "Vertnin-like", "go_ids": [], "go_terms": [], "name": "Vertnin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038823": {"description": "Mediator-associated protein 2, plant", "go_ids": [], "go_terms": [], "name": "MED2_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038824": {"description": "Protein shortage in chiasmata 1-like", "go_ids": ["GO:0007131"], "go_terms": ["GO:0007131:reciprocal meiotic recombination:P"], "name": "SHOC1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038825": {"description": "Apical junction component", "go_ids": ["GO:0045216"], "go_terms": ["GO:0045216:cell-cell junction organization:P"], "name": "Apical_junction", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038826": {"description": "Coiled-coil domain-containing protein 178", "go_ids": [], "go_terms": [], "name": "CCDC178", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038827": {"description": "Coiled-coil domain-containing protein 152", "go_ids": [], "go_terms": [], "name": "CCDC152", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038829": {"description": "Leukosialin", "go_ids": ["GO:0032609", "GO:2000404", "GO:0050863", "GO:0004888"], "go_terms": ["GO:0032609:type II interferon production:P", "GO:2000404:regulation of T cell migration:P", "GO:0050863:regulation of T cell activation:P", "GO:0004888:transmembrane signaling receptor activity:F"], "name": "Leukosialin", "pathway_ids": ["R-RNO-210991", "R-RNO-202733", "R-HSA-210991", "R-MMU-202733", "R-MMU-210991", "R-HSA-202733"], "pathways": ["R-RNO-210991:r:Basigin interactions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-HSA-210991:r:Basigin interactions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-210991:r:Basigin interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR038830": {"description": "Coiled-coil domain-containing protein 186", "go_ids": [], "go_terms": [], "name": "CCDC186", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038831": {"description": "Small integral membrane protein 26", "go_ids": [], "go_terms": [], "name": "SMIM26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038832": {"description": "Cell division cycle-associated protein 3", "go_ids": [], "go_terms": [], "name": "CDCA3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038833": {"description": "Testis-expressed protein 50", "go_ids": [], "go_terms": [], "name": "TEX50", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038834": {"description": "Coiled-coil domain-containing protein 175", "go_ids": [], "go_terms": [], "name": "CCDC175", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038835": {"description": "Giardin subunit beta-like", "go_ids": [], "go_terms": [], "name": "Giardin_beta-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038836": {"description": "Mediator complex subunit 16", "go_ids": ["GO:0006355", "GO:0016592"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0016592:mediator complex:C"], "name": "MED16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038837": {"description": "tRNA ligase 1", "go_ids": ["GO:0003972", "GO:0006388"], "go_terms": ["GO:0003972:RNA ligase (ATP) activity:F", "GO:0006388:tRNA splicing, via endonucleolytic cleavage and ligation:P"], "name": "tRNA_ligase_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038838": {"description": "Telomerase RNA component interacting RNase", "go_ids": ["GO:0008408", "GO:0008409"], "go_terms": ["GO:0008408:3'-5' exonuclease activity:F", "GO:0008409:5'-3' exonuclease activity:F"], "name": "TRIR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038839": {"description": "AT hook-containing protein attf-4-like", "go_ids": [], "go_terms": [], "name": "Attf-4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038840": {"description": "RWD domain-containing protein 3", "go_ids": ["GO:0033235", "GO:1902073"], "go_terms": ["GO:0033235:positive regulation of protein sumoylation:P", "GO:1902073:positive regulation of hypoxia-inducible factor-1alpha signaling pathway:P"], "name": "RWDD3", "pathway_ids": ["R-HSA-3065678"], "pathways": ["R-HSA-3065678:r:SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "type": "Family"}, "IPR038841": {"description": "Uncharacterized protein PF07_0086", "go_ids": [], "go_terms": [], "name": "PF07_0086", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038843": {"description": "Cell wall protein Sed1/Spi1", "go_ids": ["GO:0031505", "GO:0005199"], "go_terms": ["GO:0031505:fungal-type cell wall organization:P", "GO:0005199:structural constituent of cell wall:F"], "name": "Sed1/Spi1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038844": {"description": "Cilia- and flagella-associated protein 157", "go_ids": ["GO:0005929"], "go_terms": ["GO:0005929:cilium:C"], "name": "CFAP157", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038846": {"description": "DNA-directed RNA polymerase III subunit RPC9", "go_ids": ["GO:0005666", "GO:0006384"], "go_terms": ["GO:0005666:RNA polymerase III complex:C", "GO:0006384:transcription initiation at RNA polymerase III promoter:P"], "name": "RPC9", "pathway_ids": ["R-HSA-76071", "R-SCE-76066", "R-DDI-76066", "R-RNO-76071", "R-HSA-76066", "R-HSA-73980", "R-SPO-76066", "R-SPO-76061", "R-MMU-76071", "R-BTA-76071", "R-MMU-76066", "R-RNO-76066", "R-BTA-76066", "R-BTA-76061", "R-DDI-76061", "R-RNO-76061", "R-HSA-76061", "R-MMU-76061", "R-HSA-1834949", "R-HSA-73780", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR038847": {"description": "Granulysin-like", "go_ids": ["GO:0042742"], "go_terms": ["GO:0042742:defense response to bacterium:P"], "name": "Granulysin-like", "pathway_ids": ["R-HSA-6803157"], "pathways": ["R-HSA-6803157:r:Antimicrobial peptides"], "type": "Family"}, "IPR038848": {"description": "Calcium-binding tyrosine phosphorylation-regulated protein", "go_ids": ["GO:0005509", "GO:0048240"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0048240:sperm capacitation:P"], "name": "CABYR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038849": {"description": "ADP-ribosylation factor-like protein 2-binding protein", "go_ids": [], "go_terms": [], "name": "ARL2BP", "pathway_ids": ["R-XTR-83936", "R-HSA-83936", "R-BTA-83936", "R-RNO-83936", "R-MMU-83936", "R-DRE-83936"], "pathways": ["R-XTR-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-BTA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-DRE-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "type": "Family"}, "IPR038850": {"description": "Endothelial cell-specific molecule 1", "go_ids": [], "go_terms": [], "name": "ESM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038853": {"description": "Small integral membrane protein 9", "go_ids": [], "go_terms": [], "name": "Smim9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038856": {"description": "Death effector domain-containing protein", "go_ids": ["GO:0006915"], "go_terms": ["GO:0006915:apoptotic process:P"], "name": "DEDD/DEDD2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038857": {"description": "Coiled-coil domain-containing protein 196", "go_ids": [], "go_terms": [], "name": "CCDC196", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038858": {"description": "Secretogranin-2", "go_ids": [], "go_terms": [], "name": "ScgII", "pathway_ids": ["R-RNO-381426", "R-BTA-8957275", "R-RNO-8957275", "R-DRE-381426", "R-MMU-381426", "R-BTA-381426", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-DRE-8957275"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8957275:r:Post-translational protein phosphorylation"], "type": "Family"}, "IPR038859": {"description": "DNA-binding protein RHL1", "go_ids": ["GO:0042023", "GO:0003677"], "go_terms": ["GO:0042023:DNA endoreduplication:P", "GO:0003677:DNA binding:F"], "name": "RHL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038860": {"description": "Uncharacterized protein ycf72", "go_ids": ["GO:0009507"], "go_terms": ["GO:0009507:chloroplast:C"], "name": "YCF72", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038861": {"description": "Activity-dependent neuroprotector homeobox protein", "go_ids": [], "go_terms": [], "name": "ADNP/ADNP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038862": {"description": "Chloroplast thylakoid lumenal protein MPH2", "go_ids": ["GO:0010206"], "go_terms": ["GO:0010206:photosystem II repair:P"], "name": "MPH2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038863": {"description": "Putative NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial", "go_ids": [], "go_terms": [], "name": "Put_Complex_I_su8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038864": {"description": "Protein heading date repressor 1", "go_ids": ["GO:0009909"], "go_terms": ["GO:0009909:regulation of flower development:P"], "name": "HDR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038867": {"description": "WW domain-containing adapter protein with coiled-coil", "go_ids": [], "go_terms": [], "name": "WAC", "pathway_ids": ["R-MMU-8866654", "R-HSA-8866654", "R-XTR-8866654", "R-DME-8866654"], "pathways": ["R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-XTR-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Family"}, "IPR038868": {"description": "BRCA1-A complex subunit RAP80", "go_ids": ["GO:0070531", "GO:0006302", "GO:0070530"], "go_terms": ["GO:0070531:BRCA1-A complex:C", "GO:0006302:double-strand break repair:P", "GO:0070530:K63-linked polyubiquitin modification-dependent protein binding:F"], "name": "RAP80", "pathway_ids": ["R-MMU-69473", "R-HSA-5689901", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-69473", "R-RNO-5693565", "R-MMU-5689901", "R-RNO-5693607", "R-HSA-5693565", "R-RNO-5689901", "R-RNO-5693571", "R-MMU-5693571", "R-RNO-69473", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5689901:r:Metalloprotease DUBs", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Family"}, "IPR038869": {"description": "Defect at low temperature protein 1", "go_ids": [], "go_terms": [], "name": "DLT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038870": {"description": "Ubiquitin-associated protein 1", "go_ids": ["GO:0043130", "GO:0043162", "GO:0000813"], "go_terms": ["GO:0043130:ubiquitin binding:F", "GO:0043162:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway:P", "GO:0000813:ESCRT I complex:C"], "name": "UBAP1", "pathway_ids": ["R-RNO-917729", "R-HSA-9610379", "R-HSA-917729", "R-DRE-917729", "R-MMU-917729", "R-HSA-174490", "R-HSA-9615710", "R-HSA-162588"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-162588:r:Budding and maturation of HIV virion"], "type": "Family"}, "IPR038872": {"description": "Putative glutathione transferase 3", "go_ids": [], "go_terms": [], "name": "Put_GTT3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038873": {"description": "Uncharacterized protein CXorf66", "go_ids": [], "go_terms": [], "name": "CXorf66", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038874": {"description": "Transmembrane protein 253", "go_ids": [], 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yeast)", "PWY-6803:t:phosphatidylcholine acyl editing", "PWY-8395:t:linoleate metabolites biosynthesis", "PWY-8356:t:maresin biosynthesis", "PWY-8357:t:protectin biosynthesis", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-8413:t:representative whole plasma EPA-derived icosanoids", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-8412:t:representative whole plasma DHA-derived icosanoids", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I"], "type": "Family"}, "IPR038876": {"description": "Ecto-NOX disulfide-thiol exchanger 1/2", "go_ids": [], "go_terms": [], "name": "ENOX1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038877": {"description": "Thrombospondin type-1 domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "THSD1", "pathway_ids": ["R-MMU-5173214", "R-HSA-5083635", "R-HSA-5173214"], "pathways": ["R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Family"}, "IPR038879": {"description": "Golgi-associated PDZ and coiled-coil motif-containing protein", "go_ids": ["GO:0005794"], "go_terms": ["GO:0005794:Golgi apparatus:C"], "name": "GOPC", "pathway_ids": ["R-MMU-9013406", "R-HSA-5627083", "R-HSA-9013406", "R-MMU-5627083"], "pathways": ["R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-5627083:r:RHO GTPases regulate CFTR trafficking", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-5627083:r:RHO GTPases regulate CFTR trafficking"], "type": "Family"}, "IPR038880": {"description": "Uncharacterized protein MJ0871-like", "go_ids": [], "go_terms": [], "name": "MJ0871-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038881": {"description": "Yae1-like", "go_ids": [], "go_terms": [], "name": "Yae1-like", "pathway_ids": [], 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"GO:0043048:dolichyl monophosphate biosynthetic process:P"], "name": "Nus1/NgBR", "pathway_ids": ["PWY-6129", "R-DRE-446199", "R-HSA-4755609", "R-MMU-446199", "R-SPO-446199", "R-HSA-446199", "R-SCE-446199"], "pathways": ["PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-4755609:r:Defective DHDDS causes RP59", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-446199:r:Synthesis of dolichyl-phosphate"], "type": "Family"}, "IPR038888": {"description": "Cilia- and flagella-associated protein 36", "go_ids": [], "go_terms": [], "name": "CFAP36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038889": {"description": "Shugoshin 1/2", "go_ids": ["GO:0000775"], "go_terms": ["GO:0000775:chromosome, centromeric region:C"], "name": "Shugoshin1/2", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-MMU-2467813", "R-HSA-69273", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-HSA-68877", "R-HSA-5663220", "R-MMU-69273", "R-MMU-9648025", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle 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["GO:0015929"], "go_terms": ["GO:0015929:hexosaminidase activity:F"], "name": "HEXDC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038902": {"description": "Integrator complex subunit 1", "go_ids": ["GO:0032039", "GO:0034474"], "go_terms": ["GO:0032039:integrator complex:C", "GO:0034474:U2 snRNA 3'-end processing:P"], "name": "INTS1", "pathway_ids": ["R-HSA-6807505", "R-DME-6807505", "R-MMU-6807505", "R-DDI-6807505"], "pathways": ["R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR038903": {"description": "Allergen Asp f 4", "go_ids": ["GO:0005576", "GO:0019863"], "go_terms": ["GO:0005576:extracellular region:C", "GO:0019863:IgE binding:F"], "name": "Allergen_Asp_f_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038904": {"description": "BRCA1-associated ATM activator 1", "go_ids": ["GO:0006974", "GO:0008283"], "go_terms": ["GO:0006974:DNA damage response:P", "GO:0008283:cell population proliferation:P"], "name": "BRAT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038905": {"description": "Armadillo repeat-containing protein 2", "go_ids": [], "go_terms": [], "name": "ARMC2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038906": {"description": "Tetratricopeptide repeat protein 36", "go_ids": [], "go_terms": [], "name": "TTC36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038909": {"description": "Protein effector of transcription", "go_ids": ["GO:0006355", "GO:0003677"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003677:DNA binding:F"], "name": "Effector_transcript", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038910": {"description": "Proline-rich protein Hua1-like", "go_ids": [], "go_terms": [], "name": "Hua1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038911": {"description": "Sodium channel and clathrin linker 1", "go_ids": ["GO:0045162"], "go_terms": ["GO:0045162:clustering of voltage-gated sodium channels:P"], "name": "SCLT1", "pathway_ids": ["R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912"], "pathways": ["R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR038914": {"description": "DDB1- and CUL4-associated factor 15", "go_ids": ["GO:0016567"], "go_terms": ["GO:0016567:protein ubiquitination:P"], "name": "DCAF15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038915": {"description": "Proline-rich protein 29-like", "go_ids": [], "go_terms": [], "name": "PRR29-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038916": {"description": "Protein FAM118", "go_ids": [], "go_terms": [], "name": "FAM118", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038917": {"description": "Malonyl-CoA decarboxylase", "go_ids": ["GO:0050080", "GO:0006633"], "go_terms": ["GO:0050080:malonyl-CoA decarboxylase activity:F", "GO:0006633:fatty acid biosynthetic process:P"], "name": "Malonyl_CoA_deC", "pathway_ids": ["PWY-7485", "PWY-8358", "R-RNO-390247", "R-RNO-9033241", "R-MMU-9033241", "R-HSA-9033241", "R-HSA-390247", "R-MMU-390247"], "pathways": ["PWY-7485:t:tetracenomycin C biosynthesis", "PWY-8358:t:curacin A biosynthesis", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Family"}, "IPR038919": {"description": "STB2/STB2", "go_ids": [], "go_terms": [], "name": "STB2/STB2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038920": {"description": "At3g056750-like", "go_ids": [], "go_terms": [], "name": "At3g05675-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038921": {"description": "Uncharacterized protein YOR389W-like", "go_ids": [], "go_terms": [], "name": "YOR389W-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038923": {"description": "Centrobin", "go_ids": ["GO:0007099", "GO:1902017"], "go_terms": ["GO:0007099:centriole replication:P", "GO:1902017:regulation of cilium assembly:P"], "name": "Centrobin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038925": {"description": "UV-B-induced protein At3g17800-like", "go_ids": [], "go_terms": [], "name": "At3g17800-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038926": {"description": "Centrosomal protein of 55kDa", "go_ids": ["GO:0000281", "GO:0051896"], "go_terms": ["GO:0000281:mitotic cytokinesis:P", "GO:0051896:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction:P"], "name": "CEP55", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038927": {"description": "Uncharacterized protein C6orf163", "go_ids": [], "go_terms": [], "name": "C6orf163", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038928": {"description": "Protein LAZY1", "go_ids": ["GO:0009630", "GO:2000012"], "go_terms": ["GO:0009630:gravitropism:P", "GO:2000012:regulation of auxin polar transport:P"], "name": "LAZY1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038929": {"description": "Coiled-coil domain-containing protein 13", "go_ids": [], "go_terms": [], "name": "CCDC13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038930": {"description": "Precursor of CEP13/CEP14", "go_ids": ["GO:0006970", "GO:0006995"], "go_terms": ["GO:0006970:response to osmotic stress:P", "GO:0006995:cellular response to nitrogen starvation:P"], "name": "CEP13/CEP14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038931": {"description": "Probable NAD(P)H dehydrogenase subunit CRR3, chloroplastic", "go_ids": ["GO:0009773", "GO:0010598", "GO:0009535"], "go_terms": ["GO:0009773:photosynthetic electron transport in photosystem I:P", "GO:0010598:NAD(P)H dehydrogenase complex (plastoquinone):C", "GO:0009535:chloroplast thylakoid membrane:C"], "name": "CRR3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038932": {"description": "PCNA-interacting partner", "go_ids": ["GO:2000042"], "go_terms": ["GO:2000042:negative regulation of double-strand break repair via homologous recombination:P"], "name": "PARPBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038933": {"description": "Ovate protein family", "go_ids": ["GO:0045892"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "Ovate", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038934": {"description": "Uncharacterized protein At5g64816-like", "go_ids": [], "go_terms": [], "name": "At5g64816-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038935": {"description": "Uncharacterized protein C5orf52", "go_ids": [], "go_terms": [], "name": "C5orf52", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038936": {"description": "Protein maintenance of PSII under high light 1", "go_ids": ["GO:0009535", "GO:0061635"], "go_terms": ["GO:0009535:chloroplast thylakoid membrane:C", "GO:0061635:regulation of protein complex stability:P"], "name": "MPH1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038937": {"description": "Rop guanine nucleotide exchange factor", "go_ids": ["GO:0005085"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "RopGEF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038938": {"description": "Beta-carotene isomerase D27-like", "go_ids": [], "go_terms": [], "name": "D27-like", "pathway_ids": ["PWY-7101"], "pathways": ["PWY-7101:t:5-deoxystrigol biosynthesis"], "type": "Family"}, "IPR038939": {"description": "Plastid division protein PDV1/PDV2", "go_ids": ["GO:0010020"], "go_terms": ["GO:0010020:chloroplast fission:P"], "name": "PDV1/PDV2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038940": {"description": "Noncompact myelin-associated protein", "go_ids": ["GO:0005886", "GO:0033270", "GO:0043220", "GO:0031641", "GO:0019911"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0033270:paranode region of axon:C", "GO:0043220:Schmidt-Lanterman incisure:C", "GO:0031641:regulation of myelination:P", "GO:0019911:structural constituent of myelin sheath:F"], "name": "NCMAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038941": {"description": "At4g14100-like", "go_ids": [], "go_terms": [], "name": "At4g14100-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038942": {"description": "Transmembrane protein 52", "go_ids": [], "go_terms": [], "name": "TMEM52", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038943": {"description": "PLD-regulated protein1-like", "go_ids": ["GO:0070300"], "go_terms": ["GO:0070300:phosphatidic acid binding:F"], "name": "PLDrp1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038944": {"description": "Outer envelope membrane protein 7-like", "go_ids": [], "go_terms": [], "name": "OEP7-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038945": {"description": "Methyl-CpG-binding domain-containing protein 13-like", "go_ids": [], "go_terms": [], "name": "MBD13-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038946": {"description": "F-box only protein 47", "go_ids": [], "go_terms": [], "name": "FBXO47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038947": {"description": "At3g27210-like", "go_ids": [], "go_terms": [], "name": "At3g27210-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038948": {"description": "Protein POLR1D, isoform 2-like", "go_ids": [], "go_terms": [], "name": "POLR1D-like", "pathway_ids": ["R-HSA-76071", "R-HSA-73772", "R-HSA-73863", "R-HSA-76066", "R-HSA-73980", "R-HSA-427413", "R-HSA-1834949", "R-HSA-5250924", "R-HSA-76061", "R-HSA-73780", "R-HSA-749476", "R-HSA-73762"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Family"}, "IPR038949": {"description": "Tektin-like protein 1", "go_ids": [], "go_terms": [], "name": "TEKTL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038950": {"description": "BEN domain-containing protein 4", "go_ids": [], "go_terms": [], "name": "BEND4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038951": {"description": "Outer envelope pore protein 37-like", "go_ids": ["GO:0005216", "GO:0006812"], "go_terms": ["GO:0005216:monoatomic ion channel activity:F", "GO:0006812:monoatomic cation transport:P"], "name": "OEP37-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038952": {"description": "Protein TOPAZ1", "go_ids": [], "go_terms": [], "name": "TOPAZ1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038953": {"description": "Putative deaminase APOBEC-4", "go_ids": [], "go_terms": [], "name": "APOBEC4", "pathway_ids": ["PWY-7081", "R-RNO-72200", "R-RNO-75094", "R-HSA-72200", "R-MMU-75094", "R-MMU-72200", "R-HSA-75094"], "pathways": ["PWY-7081:t:4-aminophenol degradation", "R-RNO-72200:r:mRNA Editing: C to U Conversion", "R-RNO-75094:r:Formation of the Editosome", "R-HSA-72200:r:mRNA Editing: C to U Conversion", "R-MMU-75094:r:Formation of the Editosome", "R-MMU-72200:r:mRNA Editing: C to U Conversion", "R-HSA-75094:r:Formation of the Editosome"], "type": "Family"}, "IPR038954": {"description": "Casein kinase II subunit alpha'-interacting protein", "go_ids": [], "go_terms": [], "name": "CSNKA2IP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038955": {"description": "Protein PriA/CPL1", "go_ids": [], "go_terms": [], "name": "PriA/CPL1_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038956": {"description": "Late embryogenesis abundant protein, LEA_5 subgroup", "go_ids": [], "go_terms": [], "name": "LEA_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038958": {"description": "Protein plastid transcriptionally active 7", "go_ids": ["GO:0042793", "GO:0000427"], "go_terms": ["GO:0042793:plastid transcription:P", "GO:0000427:plastid-encoded plastid RNA polymerase complex:C"], "name": "PTAC7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038959": {"description": "Prp19", "go_ids": ["GO:0061630", "GO:0000398", "GO:0000974"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0000398:mRNA splicing, via spliceosome:P", "GO:0000974:Prp19 complex:C"], "name": "Prp19", "pathway_ids": ["PWY-7511", "R-DDI-6782135", "R-RNO-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-72163", "R-BTA-6782135", "R-RNO-6782135", "R-DDI-6781823", "R-RNO-72163", "R-DDI-6782210", "R-HSA-6782135", "R-CEL-6782210", "R-DDI-72163", "R-HSA-6781823", "R-CEL-6781823", "R-RNO-6782210", "R-HSA-72163", "R-BTA-6781823", "R-MMU-6781823", "R-SPO-6782210", "R-CEL-6782135", "R-HSA-6782210", "R-BTA-6782210", "R-MMU-6782210", "R-SPO-6782135", "R-CEL-72163", "R-SCE-6782210", "R-SPO-72163", "R-HSA-9918481", "R-SCE-6782135", "R-BTA-72163"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6782135:r:Dual incision in TC-NER", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-6782135:r:Dual incision in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR038961": {"description": "Protein PEP-related development arrested 1", "go_ids": ["GO:0042644", "GO:0006355"], "go_terms": ["GO:0042644:chloroplast nucleoid:C", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "PRDA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038962": {"description": "Transmembrane protein 158", "go_ids": [], "go_terms": [], "name": "TMEM158", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038963": {"description": "Uncharacterized protein C17orf107", "go_ids": [], "go_terms": [], "name": "C17orf107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038964": {"description": "Alpha-L-arabinofuranosidase B", "go_ids": ["GO:0046556", "GO:0019566"], "go_terms": ["GO:0046556:alpha-L-arabinofuranosidase activity:F", "GO:0019566:arabinose metabolic process:P"], "name": "ABFB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038966": {"description": "Translation machinery-associated protein 17", "go_ids": ["GO:0070682"], "go_terms": ["GO:0070682:proteasome regulatory particle assembly:P"], "name": "TMA17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038967": {"description": "DSC E3 ubiquitin ligase complex subunit 4-like", "go_ids": ["GO:0032933", "GO:0044695"], "go_terms": ["GO:0032933:SREBP signaling pathway:P", "GO:0044695:Dsc E3 ubiquitin ligase complex:C"], "name": "Dsc4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038968": {"description": "Centriolar satellite-associated tubulin polyglutamylase complex regulator 1", "go_ids": [], "go_terms": [], "name": "CSTPP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038969": {"description": "Flap endonuclease", "go_ids": ["GO:0033567", "GO:0017108"], "go_terms": ["GO:0033567:DNA replication, Okazaki fragment processing:P", "GO:0017108:5'-flap endonuclease activity:F"], "name": "FEN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038970": {"description": "Polysaccharide lyase 8", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "Lyase_8", "pathway_ids": ["PWY-7645"], "pathways": ["PWY-7645:t:hyaluronan degradation"], "type": "Family"}, "IPR038971": {"description": "Cyclin-dependent protein kinase inhibitor SMR11/SMR16", "go_ids": [], "go_terms": [], "name": "SMR11/SMR16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038972": {"description": "Inner membrane protein YiaA-like", "go_ids": [], "go_terms": [], "name": "YiaA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038973": {"description": "DNA mismatch repair protein MutL/Mlh/Pms-like", "go_ids": ["GO:0032300", "GO:0006298", "GO:0016887", "GO:0140664"], "go_terms": ["GO:0032300:mismatch repair complex:C", "GO:0006298:mismatch repair:P", "GO:0016887:ATP hydrolysis activity:F", "GO:0140664:ATP-dependent DNA damage sensor activity:F"], "name": "MutL/Mlh/Pms-like", "pathway_ids": ["R-GGA-5358565", "R-RNO-5358565", "R-HSA-5545483", "R-SCE-5358565", "R-SPO-5358565", "R-HSA-912446", "R-HSA-5358606", "R-HSA-5358565", "R-DDI-5358565", "R-HSA-6796648", "R-MMU-5358565", "R-HSA-5632987"], "pathways": ["R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632987:r:Defective Mismatch Repair Associated With PMS2"], "type": "Family"}, "IPR038974": {"description": "Protein Casparian strip integrity factor 1/2", "go_ids": [], "go_terms": [], "name": "CIF1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038975": {"description": "Thionin-like protein", "go_ids": [], "go_terms": [], "name": "THNL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038976": {"description": "Protein snakeskin", "go_ids": ["GO:0019991"], "go_terms": ["GO:0019991:septate junction assembly:P"], "name": "Ssk", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038977": {"description": "Zinc finger protein 428", "go_ids": [], "go_terms": [], "name": "ZNF428", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038978": {"description": "Protein MJ0935", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "MJ0935", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038979": {"description": "Pesticidal crystal protein", "go_ids": [], "go_terms": [], "name": "Pest_crys", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038980": {"description": "Serine/threonine-protein kinase ATM, plant", "go_ids": ["GO:0004674", "GO:0006974"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0006974:DNA damage response:P"], "name": "ATM_plant", "pathway_ids": ["R-DME-6803204", "R-HSA-5685942", "R-MMU-5693571", "R-HSA-5693616", "R-HSA-9704646", "R-HSA-349425", "R-SCE-2559586", "R-MMU-6804756", "R-DME-5693565", "R-HSA-5693565", "R-MMU-5693616", "R-HSA-6796648", "R-SPO-9664873", "R-MMU-69541", "R-SPO-6804756", "R-MMU-5685938", "R-MMU-349425", "R-MMU-5693565", "R-MMU-69473", "R-MMU-9664873", "R-SCE-5693565", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-HSA-6804757", "R-HSA-912446", "R-MMU-6803207", "R-SCE-9664873", "R-DME-9664873", "R-SCE-5693548", "R-MMU-5693568", "R-MMU-5693579", "R-SPO-6803207", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-DME-5693607", "R-MMU-6804760", "R-MMU-5693548", "R-HSA-6803207", "R-HSA-69473", "R-MMU-2559586", "R-MMU-6804757", "R-HSA-9709603", "R-MMU-5685942", "R-SPO-5693565", "R-HSA-6804760", "R-DME-6804756", "R-HSA-5693571", "R-MMU-6803204", "R-HSA-6804756", "R-SPO-2559586", "R-HSA-9704331", "R-HSA-6803204", "R-DME-6803207", "R-DME-2559586", "R-HSA-69541", "R-SPO-5693548", "R-HSA-5693554", "R-HSA-5693548", "R-DME-5693548", "R-HSA-5693579", "R-HSA-2559586", "R-DME-69541", "R-HSA-9664873"], "pathways": ["R-DME-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-9664873:r:Pexophagy", "R-MMU-69541:r:Stabilization of p53", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-9664873:r:Pexophagy", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-912446:r:Meiotic recombination", "R-MMU-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-SCE-9664873:r:Pexophagy", "R-DME-9664873:r:Pexophagy", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DME-5693607:r:Processing of DNA double-strand break ends", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-69541:r:Stabilization of p53", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-69541:r:Stabilization of p53", "R-HSA-9664873:r:Pexophagy"], "type": "Family"}, "IPR038981": {"description": "Polyadenylate-binding protein-interacting protein 5/6", "go_ids": [], "go_terms": [], "name": "CID5/CID6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038982": {"description": "NrpR repressor", "go_ids": [], "go_terms": [], "name": "NrpR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038983": {"description": "C2 domain-containing protein 5", "go_ids": ["GO:0005544"], "go_terms": ["GO:0005544:calcium-dependent phospholipid binding:F"], "name": "C2CD5", "pathway_ids": ["R-HSA-1445148"], "pathways": ["R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "type": "Family"}, "IPR038985": {"description": "OPENER-like", "go_ids": [], "go_terms": [], "name": "OPRN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038986": {"description": "Cryptic loci regulator 2", "go_ids": ["GO:0031507", "GO:0070824"], "go_terms": ["GO:0031507:heterochromatin formation:P", "GO:0070824:SHREC complex:C"], "name": "Clr2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038987": {"description": "Molybdopterin biosynthesis protein MoeA-like", "go_ids": [], "go_terms": [], "name": "MoeA-like", "pathway_ids": ["PWY-8171", "R-DME-947581", "R-RNO-947581", "R-DDI-947581", "R-HSA-947581", "R-MMU-947581"], "pathways": ["PWY-8171:t:molybdenum cofactor biosynthesis", "R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-RNO-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Family"}, "IPR038988": {"description": "Something about silencing protein 4", "go_ids": ["GO:0033255"], "go_terms": ["GO:0033255:SAS acetyltransferase complex:C"], "name": "Sas4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038989": {"description": "Ubiquinone biosynthesis accessory factor UbiJ", "go_ids": ["GO:0006744"], "go_terms": ["GO:0006744:ubiquinone biosynthetic process:P"], "name": "UbiJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038990": {"description": "LBH domain", "go_ids": [], "go_terms": [], "name": "LBH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR038991": {"description": "Caspase activity and apoptosis inhibitor 1", "go_ids": ["GO:0042981"], "go_terms": ["GO:0042981:regulation of apoptotic process:P"], "name": "CAAP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038992": {"description": "Transmembrane protein 204", "go_ids": [], "go_terms": [], "name": "TMEM204", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038993": {"description": "Internal virion protein Gp15", "go_ids": ["GO:0039678"], "go_terms": ["GO:0039678:symbiont genome ejection through host cell envelope:P"], "name": "Gp15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR038996": {"description": "Internal virion protein Gp14", "go_ids": ["GO:0039678"], "go_terms": ["GO:0039678:symbiont genome ejection through host cell envelope:P"], "name": "Gp14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039000": {"description": "ATP-dependent DNA helicase DinG", "go_ids": ["GO:0003678"], "go_terms": ["GO:0003678:DNA helicase activity:F"], "name": "DinG_proteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039006": {"description": "Rho GTPase-activating protein, pG2 domain", "go_ids": [], "go_terms": [], "name": "RhoGAP_pG2", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9013405", "R-CFA-9013409", "R-HSA-416550", "R-MMU-9013106", "R-RNO-9013409", "R-RNO-9696270", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9013409", "R-CFA-9013404", "R-MMU-9013148", "R-HSA-9013106", "R-MMU-9013404", "R-RNO-416550", "R-CFA-9013149", "R-HSA-8849471", "R-HSA-9013423", "R-CFA-8849471", "R-DME-9035034", "R-DME-9013148", "R-CFA-9696264", "R-CFA-9013408", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013409", "R-DME-9013406", "R-RNO-9013408", "R-RNO-9013106", "R-RNO-9013406", "R-RNO-9013404", "R-CFA-9696270", "R-HSA-9013408", "R-MMU-8849471", "R-DME-350407", "R-MMU-9035034", "R-RNO-8849471", "R-CFA-9013406", "R-CFA-9013148", "R-DME-9013149", "R-CFA-8980692", "R-DME-8980692", "R-HSA-9696270", "R-CFA-416550", "R-RNO-9013148", "R-RNO-9696273", "R-CFA-9696273", "R-HSA-9696264", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-416550", "R-CFA-9013106", "R-MMU-9013406", "R-MMU-9013026", "R-RNO-9696264", "R-HSA-9013026", "R-DME-8849471", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9013149", "R-DME-9013423", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-CFA-9013409:r:RHOJ GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-9035034:r:RHOF GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-CFA-9696264:r:RND3 GTPase cycle", "R-CFA-9013408:r:RHOG GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-CFA-9696270:r:RND2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-350407:r:RHO1 GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CFA-8980692:r:RHOA GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-CFA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR039008": {"description": "Intermediate filament, rod domain", "go_ids": [], "go_terms": [], "name": "IF_rod_dom", "pathway_ids": ["R-HSA-6798695", "R-HSA-9013405", "R-HSA-9646399", "R-HSA-9013422", "R-RNO-2995383", "R-RNO-9013422", "R-HSA-6802952", "R-BTA-5673001", "R-CEL-4419969", "R-HSA-9918487", "R-MMU-2559584", "R-HSA-9927418", "R-DME-352238", "R-HSA-442982", "R-CEL-9035034", "R-DME-9035034", "R-MMU-9013422", "R-CFA-390522", "R-DRE-6798695", "R-CEL-2559584", "R-BTA-438066", "R-RNO-6805567", "R-SSC-9013422", "R-HSA-446107", "R-RNO-5673001", "R-MMU-5673001", "R-RNO-2980766", "R-SSC-352238", "R-MMU-9035034", "R-DRE-6805567", "R-MMU-438066", "R-MMU-390522", "R-CFA-6805567", "R-HSA-8950505", "R-HSA-6785807", "R-RNO-438066", "R-BTA-390522", "R-HSA-5673001", "R-SSC-390522", "R-MMU-9646399", "R-MMU-6809371", "R-HSA-4419969", "R-HSA-2980766", "R-HSA-9620244", "R-CFA-9013422", "R-CFA-9646399", "R-HSA-9613829", "R-MMU-6798695", "R-BTA-9646399", "R-HSA-264870", "R-RNO-4419969", "R-HSA-9609736", "R-RNO-6798695", "R-MMU-446107", "R-SSC-9646399", "R-BTA-6805567", "R-HSA-6809371", "R-HSA-9725554", "R-RNO-352238", "R-RNO-9035034", "R-HSA-1251985", "R-HSA-8862803", "R-RNO-2559584", "R-HSA-1221632", "R-SSC-4419969", "R-MMU-2980766", "R-HSA-9035034", "R-HSA-352238", "R-HSA-2559584", "R-HSA-9615710", "R-HSA-9938206", "R-SSC-2995383", "R-CFA-264870", "R-HSA-9617324", "R-HSA-9918481", "R-SSC-2980766", "R-CFA-6809371", "R-HSA-6805567", "R-MMU-2995383", "R-DME-4419969", "R-BTA-6809371", "R-HSA-9925563", "R-HSA-381038", "R-RNO-6809371", "R-RNO-446107", "R-RNO-390522", "R-HSA-9927432", "R-DRE-6809371", "R-HSA-2995383", "R-MMU-352238", "R-BTA-264870", "R-BTA-9013422", "R-HSA-438066", "R-MMU-264870", "R-HSA-390522", "R-RNO-9646399", "R-MMU-4419969", "R-SSC-264870", "R-RNO-264870", "R-MMU-6805567", "R-HSA-9927426"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9646399:r:Aggrephagy", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-CEL-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-9918487:r:Dengue Virus Genome Translation and 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"R-BTA-9646399:r:Aggrephagy", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-SSC-9646399:r:Aggrephagy", "R-BTA-6805567:r:Keratinization", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-RNO-352238:r:Breakdown of the nuclear lamina", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-1221632:r:Meiotic synapsis", "R-SSC-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-2980766:r:Nuclear Envelope 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"R-RNO-6809371:r:Formation of the cornified envelope", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-DRE-6809371:r:Formation of the cornified envelope", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-352238:r:Breakdown of the nuclear lamina", "R-BTA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-9646399:r:Aggrephagy", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-SSC-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-6805567:r:Keratinization", "R-HSA-9927426:r:Developmental 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"R-HSA-1257604", "R-HSA-198203", "R-DME-5673001", "R-RNO-9842663", "R-RNO-1257604", "R-RNO-109704", "R-MMU-9842663", "R-DME-6811558", "R-MMU-198203", "R-MMU-2428928", "R-MMU-112412", "R-HSA-112399", "R-MMU-9027284", "R-HSA-9027276", "R-MMU-74713", "R-RNO-1266695", "R-MMU-109704", "R-DME-112399", "R-HSA-109704", "R-DME-112412", "R-MMU-1257604", "R-HSA-9842663", "R-HSA-74749", "R-MMU-9006335", "R-RNO-74713", "R-MMU-112399", "R-DME-74749", "R-RNO-2428928", "R-HSA-201556", "R-HSA-112412", "R-HSA-9027277", "R-HSA-2428928", "R-MMU-74749", "R-HSA-9725370"], "pathways": ["R-MMU-1266695:r:Interleukin-7 signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-RNO-74749:r:Signal attenuation", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-201556:r:Signaling by ALK", "R-RNO-112399:r:IRS-mediated signalling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", 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"R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-SSC-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Family"}, "IPR039018": {"description": "Endonuclease VapC20-like", "go_ids": ["GO:0004521"], "go_terms": ["GO:0004521:RNA endonuclease activity:F"], "name": "VapC20-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039019": {"description": "Cation channel sperm-associated auxiliary subunit zeta", "go_ids": ["GO:0036128", "GO:0030317", "GO:0048240"], "go_terms": ["GO:0036128:CatSper complex:C", "GO:0030317:flagellated sperm motility:P", "GO:0048240:sperm capacitation:P"], "name": "CATSPERZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039020": {"description": "Terpene cyclase PaxB-like", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "PaxB-like", "pathway_ids": ["PWY-6254", "PWY-6653", "PWY-6160", "PWY-5725", "PWY-5197", "PWY-5414", "PWY-7721", "PWY-3041", 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"go_terms": [], "name": "RTC4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039028": {"description": "PDK/BCKDK protein kinase", "go_ids": ["GO:0004672"], "go_terms": ["GO:0004672:protein kinase activity:F"], "name": "BCKD/PDK", "pathway_ids": ["R-DME-204174", "R-BTA-70895", "R-MMU-9837999", "R-HSA-204174", "R-SPO-5362517", "R-CEL-9837999", "R-RNO-204174", "R-DME-9837999", "R-CEL-5362517", "R-CEL-204174", "R-HSA-70895", "R-RNO-9837999", "R-HSA-9841922", "R-RNO-70895", "R-MMU-204174", "R-MMU-70895", "R-SPO-9837999", "R-MMU-5362517", "R-HSA-9912481", "R-HSA-9837999", "R-HSA-5362517", "R-DME-5362517", "R-SPO-204174", "R-RNO-5362517"], "pathways": ["R-DME-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-SPO-5362517:r:Signaling by Retinoic Acid", "R-CEL-9837999:r:Mitochondrial protein 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"R-SPO-204174:r:Regulation of pyruvate dehydrogenase (PDH) complex", "R-RNO-5362517:r:Signaling by Retinoic Acid"], "type": "Family"}, "IPR039031": {"description": "Mucolipin", "go_ids": ["GO:0005261"], "go_terms": ["GO:0005261:monoatomic cation channel activity:F"], "name": "Mucolipin", "pathway_ids": ["R-HSA-917977", "R-MMU-917977", "R-MMU-3295583", "R-HSA-3295583"], "pathways": ["R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Family"}, "IPR039032": {"description": "Rim-like", "go_ids": ["GO:0031267", "GO:0006887", "GO:0016020"], "go_terms": ["GO:0031267:small GTPase binding:F", "GO:0006887:exocytosis:P", "GO:0016020:membrane:C"], "name": "Rim-like", "pathway_ids": ["R-HSA-181430", "R-MMU-212676", "R-CEL-181430", "R-RNO-181430", "R-MMU-888590", "R-RNO-210500", "R-MMU-181430", "R-CEL-210500", "R-MMU-210500", "R-HSA-264642", "R-MMU-181429", "R-CEL-212676", "R-CEL-888590", "R-MMU-264642", "R-HSA-888590", "R-HSA-181429", "R-RNO-212676", "R-RNO-264642", "R-CEL-181429", "R-RNO-181429", "R-CEL-264642", "R-HSA-212676", "R-HSA-210500", "R-RNO-888590"], "pathways": ["R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation"], "type": "Family"}, "IPR039034": {"description": "Inositol 3,4-bisphosphate 4-phosphatase", "go_ids": ["GO:0016316"], "go_terms": ["GO:0016316:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity:F"], "name": "INPP4", "pathway_ids": ["PWY-6368", "R-RNO-1660499", "R-RNO-1660516", "R-MMU-1660516", "R-HSA-1855183", "R-MMU-1855183", "R-HSA-1660499", "R-HSA-1660516", "R-MMU-1660499", "R-RNO-1855183"], "pathways": ["PWY-6368:t:3-phosphoinositide degradation", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol"], "type": "Family"}, "IPR039036": {"description": "Granulin family", "go_ids": [], "go_terms": [], "name": "Granulin_fam", "pathway_ids": ["R-MMU-6798695", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR039038": {"description": "Aspartyl/asparaginyl beta-hydroxylase family", "go_ids": ["GO:0042264", "GO:0062101"], "go_terms": ["GO:0042264:peptidyl-aspartic acid hydroxylation:P", "GO:0062101:peptidyl-aspartic acid 3-dioxygenase activity:F"], "name": "ASPH", "pathway_ids": ["R-HSA-5578775", "R-HSA-2672351", "R-MMU-5578775", "R-MMU-2672351", "R-BTA-5578775", "R-HSA-9629569", "R-BTA-2672351"], "pathways": ["R-HSA-5578775:r:Ion homeostasis", "R-HSA-2672351:r:Stimuli-sensing channels", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-2672351:r:Stimuli-sensing channels", "R-BTA-5578775:r:Ion homeostasis", "R-HSA-9629569:r:Protein hydroxylation", "R-BTA-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR039039": {"description": "RAI1-like family", "go_ids": [], "go_terms": [], "name": "RAI1-like_fam", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-9930044"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-9930044:r:Nuclear RNA decay"], "type": "Family"}, "IPR039040": {"description": "NAB family", "go_ids": ["GO:0006355", "GO:0005634", "GO:0003712"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0005634:nucleus:C", "GO:0003712:transcription coregulator activity:F"], "name": "NAB_fam", "pathway_ids": ["R-HSA-9619665", "R-DME-9031628", "R-HSA-9031628", "R-CEL-9031628", "R-MMU-9031628"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-9031628:r:NGF-stimulated transcription", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-MMU-9031628:r:NGF-stimulated transcription"], "type": "Family"}, "IPR039041": {"description": "Nav/unc-53 family", "go_ids": ["GO:0022008"], "go_terms": ["GO:0022008:neurogenesis:P"], "name": "Nav/unc-53", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039042": {"description": "UDP-N-acetylglucosamine transferase subunit Alg13-like", "go_ids": ["GO:0006488"], "go_terms": ["GO:0006488:dolichol-linked oligosaccharide biosynthetic process:P"], "name": "Alg13-like", "pathway_ids": ["R-HSA-5633231", "R-RNO-446193", "R-HSA-446193", "R-SPO-446193"], "pathways": ["R-HSA-5633231:r:Defective ALG14 causes ALG14-CMS", "R-RNO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-HSA-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "R-SPO-446193:r:Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "type": "Family"}, "IPR039043": {"description": "Zinc finger protein-like 1", "go_ids": [], "go_terms": [], "name": "ZFPL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039044": {"description": "tRNA:m(4)X modification enzyme Trm13", "go_ids": ["GO:0030488"], "go_terms": ["GO:0030488:tRNA methylation:P"], "name": "Trm13", "pathway_ids": ["PWY-6829", "R-HSA-6782315"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR039045": {"description": "Schwannomin interacting 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"R-HSA-9937008", "R-HSA-6793080"], "pathways": ["PWY-7599:t:anditomin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-8341:t:N1-methyl-N3-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis", "PWY-7251:t:pentacyclic triterpene biosynthesis", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Family"}, "IPR039049": {"description": "Elongin B", "go_ids": ["GO:0070449", "GO:0030891", "GO:0006368"], "go_terms": ["GO:0070449:elongin complex:C", "GO:0030891:VCB complex:C", "GO:0006368:transcription elongation by RNA polymerase II:P"], "name": "ELOB", "pathway_ids": ["R-HSA-9833109", "R-RNO-1234176", "R-MMU-6796648", "R-RNO-674695", "R-HSA-167238", "R-RNO-6796648", "R-HSA-8951664", "R-RNO-75955", "R-HSA-9010553", "R-HSA-167243", "R-RNO-9705462", "R-HSA-983168", "R-HSA-6796648", "R-MMU-9954709", "R-MMU-674695", "R-MMU-75955", "R-MMU-1234176", "R-MMU-9705462", "R-MMU-112382", 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"R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-8951664:r:Neddylation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Family"}, "IPR039050": {"description": "GATA zinc finger domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "GATAD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039051": {"description": "SE-cephalotoxin-like", "go_ids": [], "go_terms": [], "name": "SE-CTX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039052": {"description": "Antitoxin PemI-like", "go_ids": ["GO:0097351"], "go_terms": ["GO:0097351:toxin sequestering activity:F"], "name": "Antitox_PemI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039055": {"description": "MCU family", "go_ids": ["GO:0051560"], "go_terms": ["GO:0051560:mitochondrial calcium ion homeostasis:P"], "name": "MCU_fam", "pathway_ids": ["R-DRE-8949215", "R-HSA-8949215", "R-DDI-8949215", "R-MMU-8949215", "R-CEL-8949664", "R-DME-8949664", "R-HSA-8949664", "R-MMU-8949664", "R-DME-8949215", "R-CEL-8949215"], "pathways": ["R-DRE-8949215:r:Mitochondrial calcium ion transport", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-DDI-8949215:r:Mitochondrial calcium ion transport", "R-MMU-8949215:r:Mitochondrial calcium ion transport", "R-CEL-8949664:r:Processing of SMDT1", "R-DME-8949664:r:Processing of SMDT1", "R-HSA-8949664:r:Processing of SMDT1", "R-MMU-8949664:r:Processing of SMDT1", "R-DME-8949215:r:Mitochondrial calcium ion transport", "R-CEL-8949215:r:Mitochondrial calcium ion transport"], "type": "Family"}, "IPR039056": {"description": "CDC42 small effector protein", "go_ids": ["GO:0035023", "GO:0031267"], "go_terms": ["GO:0035023:regulation of Rho protein signal transduction:P", "GO:0031267:small GTPase binding:F"], "name": "SPEC", "pathway_ids": ["R-DRE-9013148", "R-HSA-9013148"], "pathways": ["R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle"], "type": "Family"}, "IPR039057": {"description": "Sporulation-specific protein 22/ZIP4", "go_ids": ["GO:0090173"], "go_terms": ["GO:0090173:regulation of synaptonemal complex assembly:P"], "name": "Spo22/ZIP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039058": {"description": "Yippee family", "go_ids": [], "go_terms": [], "name": "Yippee_fam", "pathway_ids": ["R-SCE-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-SPO-6798695", "R-DME-6798695"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR039059": {"description": "Major vault protein", "go_ids": [], "go_terms": [], "name": "MVP", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR039060": {"description": "Antitoxin HigA", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Antitox_HigA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039061": {"description": "MDN2-binding protein", "go_ids": ["GO:0031396"], "go_terms": ["GO:0031396:regulation of protein ubiquitination:P"], "name": "MTBP", "pathway_ids": ["R-MMU-9766229", "R-HSA-9766229", "R-XTR-9766229"], "pathways": ["R-MMU-9766229:r:Degradation of CDH1", "R-HSA-9766229:r:Degradation of CDH1", "R-XTR-9766229:r:Degradation of CDH1"], "type": "Family"}, "IPR039062": {"description": "Spermatogenesis-associated protein 1", "go_ids": [], "go_terms": [], "name": "SPAT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039063": {"description": "Riboflavin kinase, CTP-dependent", "go_ids": [], "go_terms": [], "name": "RibK_CTP-dep", "pathway_ids": ["PWY-6167"], "pathways": ["PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Family"}, "IPR039064": {"description": "Zinc finger protein 750-like, zinc finger", "go_ids": [], "go_terms": [], "name": "ZNF750_Znf", "pathway_ids": ["R-MMU-212436", "R-HSA-212436", "R-BTA-212436"], "pathways": ["R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Domain"}, "IPR039065": {"description": "AcoX-like", "go_ids": [], "go_terms": [], "name": "AcoX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039066": {"description": "Hepatocyte nuclear factor 1", "go_ids": ["GO:0006357", "GO:0001889", "GO:0030073", "GO:0031016"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0001889:liver development:P", "GO:0030073:insulin secretion:P", "GO:0031016:pancreas development:P"], "name": "HNF-1", "pathway_ids": ["R-HSA-9937080", "R-HSA-9925563", "R-HSA-9831926", "R-HSA-210745", "R-HSA-9925561", "R-HSA-210744", "R-HSA-210747"], "pathways": ["R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-9831926:r:Nephron development", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-210747:r:Regulation of gene expression in early pancreatic precursor cells"], "type": "Family"}, "IPR039068": {"description": "Pyrroloquinoline-quinone synthase-like", "go_ids": [], "go_terms": [], "name": "PqqC-like", "pathway_ids": ["PWY-6420"], "pathways": ["PWY-6420:t:pyrroloquinoline quinone biosynthesis"], "type": "Family"}, "IPR039069": {"description": "Carbohydrate esterase 7 family", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "CE7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039072": {"description": "ATP synthase protein I, Bacilli-type", "go_ids": [], "go_terms": [], "name": "ATP_synth_I_Bacilli", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039074": {"description": "GGGP/HepGP synthase group I", "go_ids": [], "go_terms": [], "name": "GGGP/HepGP_synthase_I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039076": {"description": "Cell division protein DivIC", "go_ids": ["GO:0051301"], "go_terms": ["GO:0051301:cell division:P"], "name": "DivIC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039078": {"description": "Gastric inhibitory polypeptide", "go_ids": ["GO:0050796", "GO:0009749", "GO:0042304"], "go_terms": ["GO:0050796:regulation of insulin secretion:P", "GO:0009749:response to glucose:P", "GO:0042304:regulation of fatty acid biosynthetic process:P"], "name": "GIP", "pathway_ids": ["R-MMU-400511", "R-RNO-420092", "R-RNO-400511", "R-HSA-420092", "R-HSA-418555", "R-MMU-418555", "R-HSA-400511", "R-MMU-420092"], "pathways": ["R-MMU-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-RNO-420092:r:Glucagon-type ligand receptors", "R-RNO-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-HSA-420092:r:Glucagon-type ligand receptors", "R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-MMU-420092:r:Glucagon-type ligand receptors"], "type": "Family"}, "IPR039085": {"description": "DDB1- and CUL4-associated factor 10", "go_ids": [], "go_terms": [], "name": "DCA10", "pathway_ids": ["R-MMU-8951664", "R-DRE-8951664", "R-XTR-8951664", "R-HSA-8951664", "R-DME-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-XTR-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation"], "type": "Family"}, "IPR039087": {"description": "Deubiquitinating protein VCPIP1", "go_ids": ["GO:0004843", "GO:0016567"], "go_terms": ["GO:0004843:cysteine-type deubiquitinase activity:F", "GO:0016567:protein ubiquitination:P"], "name": "VCPIP1", "pathway_ids": ["R-MMU-5689896", "R-HSA-5689896", "R-RNO-5689896"], "pathways": ["R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-RNO-5689896:r:Ovarian tumor domain proteases"], "type": "Family"}, "IPR039089": {"description": "Immunoglobulin superfamily member 6", "go_ids": [], "go_terms": [], "name": "IGSF6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039090": {"description": "T-cell antigen CD7", "go_ids": ["GO:0038023", "GO:0016020", "GO:0002250"], "go_terms": ["GO:0038023:signaling receptor activity:F", "GO:0016020:membrane:C", "GO:0002250:adaptive immune response:P"], "name": "CD7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039091": {"description": "Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressor", "go_ids": ["GO:0009410", "GO:0006805"], "go_terms": ["GO:0009410:response to xenobiotic stimulus:P", "GO:0006805:xenobiotic metabolic process:P"], "name": "AHR/AHRR", "pathway_ids": ["R-HSA-1989781", "R-HSA-211981", "R-RNO-8937144", "R-HSA-211945", "R-CEL-211945", "R-MMU-8937144", "R-RNO-211981", "R-MMU-211945", "R-RNO-211945", "R-MMU-211981", "R-MMU-211976", "R-RNO-211976", "R-CEL-8937144", "R-HSA-211976", "R-HSA-8937144"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-211981:r:Xenobiotics", "R-RNO-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-CEL-211945:r:Phase I - Functionalization of compounds", "R-MMU-8937144:r:Aryl hydrocarbon receptor signalling", "R-RNO-211981:r:Xenobiotics", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-RNO-211945:r:Phase I - Functionalization of compounds", "R-MMU-211981:r:Xenobiotics", "R-MMU-211976:r:Endogenous sterols", "R-RNO-211976:r:Endogenous sterols", "R-CEL-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-211976:r:Endogenous sterols", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling"], "type": "Family"}, "IPR039093": {"description": "Protein XRP2", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "XRP2", "pathway_ids": ["R-MMU-5624138", "R-HSA-5624138", "R-DRE-5624138"], "pathways": ["R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium"], "type": "Family"}, "IPR039098": {"description": "TERF1-interacting nuclear factor 2", "go_ids": ["GO:0070187", "GO:0016233"], "go_terms": ["GO:0070187:shelterin complex:C", "GO:0016233:telomere capping:P"], "name": "TINF2", "pathway_ids": ["R-MMU-174430", "R-HSA-171306", "R-MMU-110330", "R-HSA-174414", "R-MMU-2559586", "R-MMU-174417", "R-HSA-174430", "R-HSA-110328", "R-HSA-1221632", "R-HSA-174411", "R-MMU-110331", "R-HSA-171319", "R-MMU-9670095", "R-MMU-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110331:r:Cleavage of the damaged purine", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Family"}, "IPR039099": {"description": "Pannexin", "go_ids": ["GO:0032732", "GO:0006812", "GO:0015267"], "go_terms": ["GO:0032732:positive regulation of interleukin-1 production:P", "GO:0006812:monoatomic cation transport:P", "GO:0015267:channel activity:F"], "name": "Pannexin", "pathway_ids": ["R-RNO-112303", "R-HSA-112303", "R-HSA-9856530", "R-HSA-9856532", "R-MMU-112303", "R-RNO-844456", "R-MMU-844456", "R-HSA-844456"], "pathways": ["R-RNO-112303:r:Electric Transmission Across Gap Junctions", "R-HSA-112303:r:Electric Transmission Across Gap Junctions", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-112303:r:Electric Transmission Across Gap Junctions", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Family"}, "IPR039100": {"description": "Ribosome maturation protein Sdo1/SBDS-like", "go_ids": [], "go_terms": [], "name": "Sdo1/SBDS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039101": {"description": "Thioredoxin-related transmembrane protein 2", "go_ids": [], "go_terms": [], "name": "TMX2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039102": {"description": "Protein FAM13", "go_ids": [], "go_terms": [], "name": "FAM13", "pathway_ids": ["R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013148", "R-MMU-9013149", "R-HSA-9013148", "R-MMU-8980692"], "pathways": ["R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Family"}, "IPR039103": {"description": "Centrosomal protein Spd-2/CEP192", "go_ids": ["GO:0090222", "GO:0071539", "GO:0051298"], "go_terms": ["GO:0090222:centrosome-templated microtubule nucleation:P", "GO:0071539:protein localization to centrosome:P", "GO:0051298:centrosome duplication:P"], "name": "Spd-2/CEP192", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR039104": {"description": "6-phosphogluconolactonase", "go_ids": [], "go_terms": [], "name": "6PGL", "pathway_ids": ["PWY-8004", "R-MMU-71336", "R-HSA-71336", "R-RNO-71336", "R-CEL-71336", "R-SPO-71336", "R-DME-71336", "R-SCE-71336", "R-DDI-71336"], "pathways": ["PWY-8004:t:Entner-Doudoroff pathway I", "R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-RNO-71336:r:Pentose phosphate pathway", "R-CEL-71336:r:Pentose phosphate pathway", "R-SPO-71336:r:Pentose phosphate pathway", "R-DME-71336:r:Pentose phosphate pathway", "R-SCE-71336:r:Pentose phosphate pathway", "R-DDI-71336:r:Pentose phosphate pathway"], "type": "Family"}, "IPR039109": {"description": "Large ribosomal subunit protein eL30-like", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Ribosomal_eL30-like", "pathway_ids": ["R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-GGA-72706", "R-SPO-9954709", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-MMU-6791226", "R-RNO-975957", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-HSA-72706", "R-GGA-9954716", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-DDI-72689", "R-GGA-975956", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-GGA-9954714", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-BTA-9954716", "R-MMU-975957", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-GGA-9954709", "R-BTA-9954714", "R-GGA-975957", "R-HSA-975957", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-GGA-1799339", "R-DDI-975957", "R-DDI-1799339", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-9954716:r:ZNF598 and 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(EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent 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{"description": "Signal-transducing adaptor protein STAP1/STAP2", "go_ids": ["GO:0035591"], "go_terms": ["GO:0035591:signaling adaptor activity:F"], "name": "STAP1/STAP2", "pathway_ids": ["R-HSA-8849474", "R-MMU-8849474", "R-HSA-9707564"], "pathways": ["R-HSA-8849474:r:PTK6 Activates STAT3", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-HSA-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR039112": {"description": "Phosphotyrosine interaction domain containing 1", "go_ids": ["GO:0051881", "GO:0046627", "GO:0042127"], "go_terms": ["GO:0051881:regulation of mitochondrial membrane potential:P", "GO:0046627:negative regulation of insulin receptor signaling pathway:P", "GO:0042127:regulation of cell population proliferation:P"], "name": "PID1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039113": {"description": "Autophagy-related protein 29", "go_ids": ["GO:0000045"], "go_terms": ["GO:0000045:autophagosome assembly:P"], "name": "ATG29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039116": {"description": "Coiled-coil domain-containing protein 93", "go_ids": [], "go_terms": [], "name": "CCDC93", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039119": {"description": "ABT1/Esf2", "go_ids": [], "go_terms": [], "name": "ABT1/Esf2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039120": {"description": "Ubiquitin domain-containing protein UBFD1", "go_ids": [], "go_terms": [], "name": "UBFD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039121": {"description": "Acyl-coenzyme A diphosphatase NUDT19", "go_ids": ["GO:0016818"], "go_terms": ["GO:0016818:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides:F"], "name": "NUDT19", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-390918", "R-MMU-390918", "R-RNO-9033241", "R-GGA-390918", "R-CEL-390918", "R-RNO-390918", "R-MMU-9033241", "R-GGA-9033241", "R-HSA-9033241"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-MMU-390918:r:Peroxisomal lipid metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-GGA-390918:r:Peroxisomal lipid metabolism", "R-CEL-390918:r:Peroxisomal lipid metabolism", "R-RNO-390918:r:Peroxisomal lipid metabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-GGA-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR039123": {"description": "Protein phosphatase PTC7 homolog", "go_ids": [], "go_terms": [], "name": "PPTC7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039124": {"description": "PRA1-like", "go_ids": [], "go_terms": [], "name": "PRA1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039126": {"description": "Gamma-glutamylaminecyclotransferase", "go_ids": ["GO:0061929"], "go_terms": ["GO:0061929:gamma-glutamylaminecyclotransferase activity:F"], "name": "GGACT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039127": {"description": "Multifunctional methyltransferase subunit Trm112", "go_ids": ["GO:0046982"], "go_terms": ["GO:0046982:protein heterodimerization activity:F"], "name": "Trm112", "pathway_ids": ["R-CEL-156581", "R-HSA-6790901", "R-DME-72764", "R-BTA-156581", "R-HSA-6782315", "R-SPO-72764", "R-DME-156581", "R-SCE-156581", "R-BTA-72764", "R-HSA-156581", "R-DDI-72764", "R-CEL-72764", "R-HSA-72764", "R-DDI-156581", "R-MMU-156581", "R-SCE-72764", "R-SPO-156581", "R-MMU-72764"], "pathways": ["R-CEL-156581:r:Methylation", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DME-72764:r:Eukaryotic Translation Termination", "R-BTA-156581:r:Methylation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-SPO-72764:r:Eukaryotic Translation Termination", "R-DME-156581:r:Methylation", "R-SCE-156581:r:Methylation", "R-BTA-72764:r:Eukaryotic Translation Termination", "R-HSA-156581:r:Methylation", "R-DDI-72764:r:Eukaryotic Translation Termination", "R-CEL-72764:r:Eukaryotic Translation Termination", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-DDI-156581:r:Methylation", "R-MMU-156581:r:Methylation", "R-SCE-72764:r:Eukaryotic Translation Termination", "R-SPO-156581:r:Methylation", "R-MMU-72764:r:Eukaryotic Translation Termination"], "type": "Family"}, "IPR039128": {"description": 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{"description": "NUFIP1-like", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "NUFIP1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039139": {"description": "Coiled-coil domain-containing protein 170-like", "go_ids": [], "go_terms": [], "name": "CCDC170-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039142": {"description": "NRF1/Ewg family", "go_ids": ["GO:0003700", "GO:0006357"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "NRF1/Ewg", "pathway_ids": ["R-HSA-9841251", "R-HSA-1989781", "R-HSA-2151201"], "pathways": ["R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis"], "type": "Family"}, "IPR039143": {"description": "Glucosamine 6-phosphate N-acetyltransferase-like", "go_ids": [], 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"GO:0001736:establishment of planar polarity:P"], "name": "INTU", "pathway_ids": ["R-XTR-5610787", "R-DME-450728", "R-DME-5610787", "R-DRE-5610787", "R-RNO-5610787", "R-BTA-5610787", "R-HSA-5610787", "R-MMU-5610787"], "pathways": ["R-XTR-5610787:r:Hedgehog 'off' state", "R-DME-450728:r:Inhibition of actin polymerization", "R-DME-5610787:r:Hedgehog 'off' state", "R-DRE-5610787:r:Hedgehog 'off' state", "R-RNO-5610787:r:Hedgehog 'off' state", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state"], "type": "Family"}, "IPR039153": {"description": "Fetal and adult testis-expressed transcript protein", "go_ids": ["GO:0042981"], "go_terms": ["GO:0042981:regulation of apoptotic process:P"], "name": "FATE1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039155": {"description": "Malectin", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "MLEC", "pathway_ids": ["R-HSA-532668", 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{"description": "Uncharacterized protein C19orf47-like", "go_ids": [], "go_terms": [], "name": "C19orf47-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039162": {"description": "Homeodomain-only protein", "go_ids": ["GO:0030154"], "go_terms": ["GO:0030154:cell differentiation:P"], "name": "HOPX", "pathway_ids": ["R-HSA-9725554"], "pathways": ["R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin"], "type": "Family"}, "IPR039163": {"description": "ER membrane protein complex subunit 7", "go_ids": [], "go_terms": [], "name": "EMC7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039164": {"description": "E3 ubiquitin-protein ligase UBR1-like", "go_ids": ["GO:0061630", "GO:0071596"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0071596:ubiquitin-dependent protein catabolic process via the N-end rule pathway:P"], "name": "UBR1-like", "pathway_ids": ["PWY-7511", "R-SPO-983168", "R-DME-983168", 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import", "R-SPO-1268020:r:Mitochondrial protein import", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR039176": {"description": "Osteocalcin", "go_ids": ["GO:0005509", "GO:0060348", "GO:0032571", "GO:1900076"], "go_terms": ["GO:0005509:calcium ion binding:F", "GO:0060348:bone development:P", "GO:0032571:response to vitamin K:P", "GO:1900076:regulation of cellular response to insulin stimulus:P"], "name": "Osteocalcin", "pathway_ids": ["R-HSA-159740", "R-XTR-159763", "R-HSA-159782", "R-MMU-159740", "R-MMU-159782", "R-MMU-159763", "R-XTR-159782", "R-RNO-159782", "R-RNO-159763", "R-RNO-159740", "R-HSA-8940973", "R-HSA-159763", "R-XTR-159740"], "pathways": ["R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-XTR-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated 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["GO:0000184"], "go_terms": ["GO:0000184:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay:P"], "name": "SMG9", "pathway_ids": ["R-RNO-975957", "R-XTR-975957", "R-HSA-975957", "R-CEL-975957", "R-DME-975957", "R-MMU-975957"], "pathways": ["R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Family"}, "IPR039178": {"description": "Protein Lag2", "go_ids": ["GO:0005112", "GO:0001708", "GO:0007219"], "go_terms": ["GO:0005112:Notch binding:F", "GO:0001708:cell fate 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[], "go_terms": [], "name": "CCD66", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039184": {"description": "Sterile alpha and TIR motif-containing protein 1", "go_ids": ["GO:0003953", "GO:0035591", "GO:0048678", "GO:0034128"], "go_terms": ["GO:0003953:NAD+ nucleosidase activity:F", "GO:0035591:signaling adaptor activity:F", "GO:0048678:response to axon injury:P", "GO:0034128:negative regulation of MyD88-independent toll-like receptor signaling pathway:P"], "name": "SARM1", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-RNO-166166", "R-HSA-168164", "R-RNO-937072", "R-MMU-166166", "R-HSA-937041", "R-MMU-937072", "R-HSA-937072", "R-RNO-936964", "R-HSA-166166", "R-MMU-937041", "R-HSA-936964", "R-MMU-936964", "R-RNO-937041"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and 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{"description": "Strawberry notch, AAA domain", "go_ids": [], "go_terms": [], "name": "SNO_AAA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039189": {"description": "CTD phosphatase Fcp1", "go_ids": ["GO:0008420"], "go_terms": ["GO:0008420:RNA polymerase II CTD heptapeptide repeat phosphatase activity:F"], "name": "Fcp1", "pathway_ids": ["R-SPO-113418", "R-CEL-75955", "R-MMU-6796648", "R-SPO-674695", "R-HSA-167238", "R-MMU-113418", "R-HSA-167243", "R-SCE-113418", "R-HSA-167242", "R-CEL-113418", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-CEL-674695", "R-HSA-167287", "R-HSA-167246", "R-HSA-167290", "R-HSA-167200", "R-HSA-75955", "R-CEL-112382", "R-HSA-167152", "R-SCE-674695", "R-HSA-113418", "R-SPO-6796648", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382", "R-SCE-6796648"], "pathways": ["R-SPO-113418:r:Formation of the Early Elongation Complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 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"R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes"], "type": "Family"}, "IPR039190": {"description": "Tetratricopeptide repeat protein 14", "go_ids": [], "go_terms": [], "name": "TTC14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039191": {"description": 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"R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR039195": {"description": "Ankyrin repeat domain-containing protein 40", "go_ids": [], "go_terms": [], "name": "ANKRD40", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039196": {"description": "ATP synthase assembly factor Fmc1, mitochondrial", "go_ids": ["GO:0033615"], "go_terms": ["GO:0033615:mitochondrial proton-transporting ATP synthase complex assembly:P"], "name": "Fmc1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039197": {"description": "Mrs1/Cce1", "go_ids": [], "go_terms": [], "name": "Mrs1/Cce1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039198": {"description": "Srl3/Whi5", "go_ids": ["GO:0000082"], "go_terms": ["GO:0000082:G1/S transition of mitotic cell cycle:P"], "name": "Srl3/Whi5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039199": {"description": "FAM91", "go_ids": [], "go_terms": [], "name": "FAM91", "pathway_ids": ["R-HSA-9013407", "R-DRE-9013407", "R-MMU-9013407"], "pathways": ["R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR039200": {"description": "Ectodysplasin-A receptor-associated adapter protein", "go_ids": [], "go_terms": [], "name": "EDARADD", "pathway_ids": ["R-HSA-5669034", "R-MMU-5669034"], "pathways": ["R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR039201": {"description": "PAK4-inhibitor inka", "go_ids": 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"GO:0005743:mitochondrial inner membrane:C"], "name": "NDUFA11", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-MMU-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-RNO-6799198"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-RNO-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR039206": {"description": "MORF/ORRM1/DAG-like", "go_ids": ["GO:0016554"], "go_terms": ["GO:0016554:cytidine to uridine editing:P"], "name": "MORF/ORRM1/DAG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039207": {"description": "Multiple myeloma tumor-associated protein 2-like", "go_ids": [], "go_terms": [], "name": "MMTAG2-like", "pathway_ids": ["R-MMU-6798695", "R-SPO-6798695", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR039208": {"description": "C2 calcium-dependent domain-containing protein 4", "go_ids": [], "go_terms": [], "name": "C2_Ca-dependent_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039209": {"description": "ORC ubiquitin ligase 1", "go_ids": ["GO:0006275", "GO:0004842", "GO:0006513"], "go_terms": ["GO:0006275:regulation of DNA replication:P", "GO:0004842:ubiquitin-protein transferase activity:F", "GO:0006513:protein monoubiquitination:P"], "name": "OBI1", "pathway_ids": ["PWY-7511", "R-HSA-69273", "R-MMU-69273"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition"], "type": "Family"}, "IPR039210": {"description": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3", "go_ids": [], "go_terms": [], "name": "OGFOD3", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR039212": {"description": "Ribosome-binding factor A, mitochondrial", "go_ids": [], "go_terms": [], "name": "RBFA_mitochondrial", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039213": {"description": "FAM90", "go_ids": [], "go_terms": [], "name": "FAM90", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039217": {"description": "Lymphocyte antigen 96", "go_ids": ["GO:0001530", "GO:0035662", "GO:0045087"], "go_terms": ["GO:0001530:lipopolysaccharide binding:F", "GO:0035662:Toll-like receptor 4 binding:F", "GO:0045087:innate immune response:P"], "name": "LY96", "pathway_ids": ["R-MMU-140534", "R-HSA-166058", "R-MMU-166016", "R-HSA-166016", "R-HSA-9824878", "R-MMU-937072", "R-HSA-9707616", "R-HSA-937072", "R-MMU-5686938", "R-MMU-166166", "R-HSA-166166", "R-HSA-975163", "R-HSA-936964", "R-HSA-9820960", "R-HSA-2562578", "R-MMU-9707616", "R-HSA-937041", "R-MMU-975163", "R-MMU-2562578", "R-HSA-140534", "R-HSA-9833110", "R-HSA-5686938", "R-HSA-1236974", "R-HSA-5603041", "R-MMU-937041", "R-HSA-5602498", "R-HSA-9918481", "R-MMU-9824878", "R-MMU-936964"], "pathways": ["R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9707616:r:Heme signaling", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-MMU-9707616:r:Heme signaling", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "type": "Family"}, "IPR039218": {"description": "REM family", "go_ids": [], "go_terms": [], "name": "REM_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039220": {"description": "FAM3 family", "go_ids": [], "go_terms": [], "name": "FAM3", "pathway_ids": ["R-HSA-114608", "R-BTA-114608", "R-DRE-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR039223": {"description": "Protein AATF/Bfr2", "go_ids": [], "go_terms": [], "name": "AATF/Bfr2", "pathway_ids": ["R-HSA-193648"], "pathways": ["R-HSA-193648:r:NRAGE signals death through JNK"], "type": "Family"}, "IPR039225": {"description": "Transcription factor Gibbin", "go_ids": [], "go_terms": [], "name": "AHDC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039226": {"description": "Ski3/TTC37", "go_ids": ["GO:0055087", "GO:0006401"], "go_terms": ["GO:0055087:Ski complex:C", "GO:0006401:RNA catabolic process:P"], "name": "Ski3/TTC37", "pathway_ids": ["R-SPO-429958", "R-SCE-429958", "R-HSA-429958", "R-MMU-429958"], "pathways": ["R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Family"}, "IPR039227": {"description": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) 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endothelial cells", "R-MMU-418597:r:G alpha (z) signalling events", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-8964616:r:G beta:gamma signalling through CDC42", "R-HSA-8964315:r:G beta:gamma signalling through BTK", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-MMU-392851:r:Prostacyclin signalling through prostacyclin receptor", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-163359:r:Glucagon signaling in metabolic regulation", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-DME-418597:r:G alpha (z) signalling events", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-418217:r:G beta:gamma signalling 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{"description": "Tubulin polyglutamylase complex subunit 2", "go_ids": ["GO:0018095"], "go_terms": ["GO:0018095:protein polyglutamylation:P"], "name": "TPGS2", "pathway_ids": ["R-HSA-8955332"], "pathways": ["R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Family"}, "IPR039235": {"description": "Tubulin polyglutamylase complex subunit 1", "go_ids": ["GO:0018095"], "go_terms": ["GO:0018095:protein polyglutamylation:P"], "name": "TPGS1", "pathway_ids": ["R-HSA-8955332"], "pathways": ["R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Family"}, "IPR039236": {"description": "Gastrin", "go_ids": ["GO:0005179"], "go_terms": ["GO:0005179:hormone activity:F"], "name": "GAST", "pathway_ids": ["R-MMU-416476", "R-BTA-881907", "R-RNO-881907", "R-CFA-416476", "R-MMU-881907", "R-HSA-416476", "R-HSA-881907", "R-RNO-416476", "R-BTA-416476"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", 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["R-HSA-1989781", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR039243": {"description": "Leucine-rich repeat-containing protein 25", "go_ids": [], "go_terms": [], "name": "LRRC25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039244": {"description": "Galanin-like peptide", "go_ids": [], "go_terms": [], "name": "GALP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039245": {"description": "Peroxisomal/glyoxysomal leader peptide-processing protease", "go_ids": ["GO:0004252", "GO:0016485", "GO:0005777"], "go_terms": ["GO:0004252:serine-type endopeptidase activity:F", "GO:0016485:protein processing:P", "GO:0005777:peroxisome:C"], "name": "TYSND1/DEG15", "pathway_ids": ["PWY-7884", "R-MMU-9033500", "R-HSA-9033241", "R-HSA-9033500", "R-MMU-9033241"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-MMU-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-MMU-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR039246": {"description": "Flagellar protein FlgA", "go_ids": ["GO:0044780"], "go_terms": ["GO:0044780:bacterial-type flagellum assembly:P"], "name": "Flagellar_FlgA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039247": {"description": "RNA-binding protein KhpB", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "KhpB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039248": {"description": "Phosphatase RsbX", "go_ids": [], "go_terms": [], "name": "Ptase_RsbX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039249": {"description": "G patch domain-containing protein 11", "go_ids": [], "go_terms": [], "name": "GPATCH11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039250": {"description": "CREBL2/REPTOR-BP", "go_ids": [], "go_terms": [], "name": "CREBL2/REPTOR-BP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039251": {"description": "Oxidoreductase-like domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "OXLD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039252": {"description": "Protein RALF-like 27", "go_ids": [], "go_terms": [], "name": "RALFL27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039253": {"description": "Aprataxin and PNK-like factor", "go_ids": ["GO:0008408", "GO:0003906", "GO:0006302"], "go_terms": ["GO:0008408:3'-5' exonuclease activity:F", "GO:0003906:DNA-(apurinic or apyrimidinic site) endonuclease activity:F", "GO:0006302:double-strand break repair:P"], "name": "APLF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039254": {"description": "Protein Rds1", "go_ids": [], "go_terms": [], "name": 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reductase activity:F", "GO:0045041:protein import into mitochondrial intermembrane space:P"], "name": "CHCHD4", "pathway_ids": ["R-HSA-1268020"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR039291": {"description": "Late embryogenesis abundant protein At5g17165-like", "go_ids": [], "go_terms": [], "name": "At5g17165-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039292": {"description": "Protein SICKLE", "go_ids": ["GO:0000398", "GO:0035196"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P", "GO:0035196:miRNA processing:P"], "name": "SICKLE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039293": {"description": "Transmembrane protein 81", "go_ids": [], "go_terms": [], "name": "TMEM81", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039294": {"description": "Probable RNA-binding protein EIF1AD", "go_ids": [], "go_terms": [], "name": "EIF1AD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039295": {"description": "Signaling mucin MSB2", "go_ids": ["GO:0007232", "GO:0005034", "GO:0005886"], "go_terms": ["GO:0007232:osmosensory signaling pathway via Sho1 osmosensor:P", "GO:0005034:osmosensor activity:F", "GO:0005886:plasma membrane:C"], "name": "MSB2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039297": {"description": "Cytochrome c oxidase subunit VII", "go_ids": [], "go_terms": [], "name": "COX7a", "pathway_ids": ["R-SSC-611105", "R-DRE-611105", "R-SSC-5628897", "R-DRE-9864848", "R-RNO-5628897", "R-SSC-9864848", "R-RNO-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-BTA-5628897", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-SSC-9707564", "R-HSA-9844594", "R-BTA-611105", "R-HSA-9707564", "R-MMU-5628897", "R-MMU-611105", "R-MMU-9864848", "R-DRE-9707564", "R-MMU-9707564", "R-DRE-5628897", "R-BTA-9707564"], "pathways": ["R-SSC-611105:r:Respiratory electron transport", "R-DRE-611105:r:Respiratory electron transport", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-SSC-9707564:r:Cytoprotection by HMOX1", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-BTA-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-9864848:r:Complex IV assembly", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR039298": {"description": "Acyl-coenzyme A thioesterase 13", "go_ids": ["GO:0047617"], "go_terms": ["GO:0047617:fatty acyl-CoA hydrolase activity:F"], "name": "ACOT13", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741", "R-CEL-77289", "R-SPO-77289", "R-HSA-77289", "R-MMU-77289"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis III", "PWY-7741:t:phthiocerol biosynthesis", "R-CEL-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation"], "type": "Family"}, "IPR039299": {"description": "Protein SIEVE ELEMENT OCCLUSION", "go_ids": ["GO:0010088"], "go_terms": ["GO:0010088:phloem development:P"], "name": "SEOA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039300": {"description": "Protein JASON", "go_ids": ["GO:0007142"], "go_terms": ["GO:0007142:male meiosis II:P"], "name": "JASON", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039301": {"description": "Protein Sip5/DA2", "go_ids": [], "go_terms": [], "name": "Sip5/DA2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039302": {"description": "Microtubule associated protein 10", "go_ids": ["GO:0008017", "GO:0000226"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0000226:microtubule cytoskeleton organization:P"], "name": "MAP10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039303": {"description": "Coiled-coil domain-containing protein 50", "go_ids": [], "go_terms": [], "name": "CCDC50", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039304": {"description": "Dynein assembly factor 3, axonemal", "go_ids": ["GO:0070286"], "go_terms": ["GO:0070286:axonemal dynein complex assembly:P"], "name": "DNAAF3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039305": {"description": "Protein PIN-LIKES 2/6", "go_ids": ["GO:0080162"], "go_terms": ["GO:0080162:endoplasmic reticulum to cytosol auxin transport:P"], "name": "PILS2/6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039306": {"description": "Myosin-binding protein", "go_ids": ["GO:0017022"], "go_terms": ["GO:0017022:myosin binding:F"], "name": "MYOB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039307": {"description": "GPI-anchored protein LORELEI-like", "go_ids": [], "go_terms": [], "name": "LORELEI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039308": {"description": "Growth arrest-specific protein 8", "go_ids": ["GO:0008017", "GO:0048870", "GO:0031267"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0048870:cell motility:P", "GO:0031267:small GTPase binding:F"], "name": "GAS8", "pathway_ids": ["R-MMU-5635838", "R-HSA-5635838"], "pathways": ["R-MMU-5635838:r:Activation of SMO", "R-HSA-5635838:r:Activation of SMO"], "type": "Family"}, "IPR039309": {"description": "Biopterin transporter family", "go_ids": [], "go_terms": [], "name": "BT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039310": {"description": "UBA-like domain-containing protein 1/2", "go_ids": [], "go_terms": [], "name": "UBALD1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039311": {"description": "FAM187A/B", "go_ids": [], "go_terms": [], "name": "FAM187A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039312": {"description": "Protein LITTLE ZIPPER", "go_ids": [], "go_terms": [], "name": "ZPR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039313": {"description": "Protein HEAT INTOLERANT 4", "go_ids": ["GO:1900034"], "go_terms": ["GO:1900034:regulation of cellular response to heat:P"], "name": "HIT4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039314": {"description": "Calvin cycle protein CP12-like", "go_ids": [], "go_terms": [], "name": "CP12-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039315": {"description": "Chemotaxis protein CheW", "go_ids": ["GO:0006935"], "go_terms": ["GO:0006935:chemotaxis:P"], "name": "CheW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039316": {"description": "CLAVATA3/ESR (CLE)-related protein 25/26", "go_ids": [], "go_terms": [], "name": "CLE25/26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039317": {"description": "Protein time for coffee", "go_ids": ["GO:0042752"], "go_terms": ["GO:0042752:regulation of circadian rhythm:P"], "name": "TIC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039318": {"description": "Protein O-mannose kinase", "go_ids": ["GO:0019200", "GO:0006493"], "go_terms": ["GO:0019200:carbohydrate kinase activity:F", "GO:0006493:protein O-linked glycosylation:P"], "name": "POMK", "pathway_ids": ["PWY-7979", "R-DRE-8932505", "R-MMU-8932505", "R-HSA-8932505", "R-RNO-8932505"], "pathways": ["PWY-7979:t:protein O-mannosylation III (mammals, core M3)", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-RNO-8932505:r:DAG1 core M3 glycosylations"], "type": "Family"}, "IPR039319": {"description": "Protein EARLY FLOWERING 3-like", "go_ids": ["GO:2000028"], "go_terms": ["GO:2000028:regulation of photoperiodism, flowering:P"], "name": "ELF3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039320": {"description": "RING finger protein 207", "go_ids": ["GO:0030544"], "go_terms": ["GO:0030544:Hsp70 protein binding:F"], "name": "RNF207", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039321": {"description": "Increased DNA methylation 2/3-like", "go_ids": [], "go_terms": [], "name": "IDM2/3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039322": {"description": "MOM1", "go_ids": ["GO:0031507"], "go_terms": ["GO:0031507:heterochromatin formation:P"], "name": "MOM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039323": {"description": "Ankyrin repeat domain-containing protein 45/46/60", "go_ids": [], "go_terms": [], "name": "ANKRD_45/46/60", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039324": {"description": "Protein SHORT HYPOCOTYL IN WHITE LIGHT 1", "go_ids": ["GO:0009787", "GO:0010100"], "go_terms": ["GO:0009787:regulation of abscisic acid-activated signaling pathway:P", "GO:0010100:negative regulation of photomorphogenesis:P"], "name": "SHW1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039325": {"description": "Nodulin homeobox", "go_ids": ["GO:0003697", "GO:0009908"], "go_terms": ["GO:0003697:single-stranded DNA binding:F", "GO:0009908:flower development:P"], "name": "NDX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039326": {"description": "Protein Patronus", "go_ids": ["GO:0007346"], "go_terms": ["GO:0007346:regulation of mitotic cell cycle:P"], "name": "Patronus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039327": {"description": "C2H2 finger domain transcription factor CON7-like", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "CON7-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039328": {"description": "WD repeat-containing protein 89", "go_ids": [], "go_terms": [], "name": "WDR89", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039329": {"description": "Sialate O-acetylesterase", "go_ids": ["GO:0001681"], "go_terms": ["GO:0001681:sialate O-acetylesterase activity:F"], "name": "SIAE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039330": {"description": "Chromosome alignment-maintaining phosphoprotein 1", "go_ids": ["GO:0051315"], "go_terms": ["GO:0051315:attachment of mitotic spindle microtubules to kinetochore:P"], "name": "CAMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039331": {"description": "Purple acid phosphatase-like", "go_ids": ["GO:0003993"], "go_terms": ["GO:0003993:acid phosphatase activity:F"], "name": "PAPs-like", "pathway_ids": ["PWY-6348"], "pathways": ["PWY-6348:t:phosphate acquisition"], "type": "Family"}, "IPR039333": {"description": "Partner of Y14 and mago", "go_ids": ["GO:1903259"], "go_terms": ["GO:1903259:exon-exon junction complex disassembly:P"], "name": "PYM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039335": {"description": "Sigma factor binding protein 1/2", "go_ids": [], "go_terms": [], "name": "SIB1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039336": {"description": "Midnolin", "go_ids": [], "go_terms": [], "name": "Midnolin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039338": {"description": "Zinc finger TRAF-type-containing protein 1", "go_ids": [], "go_terms": [], "name": "ZFTRAF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039339": {"description": "Inactive serine/threonine-protein kinase TEX14", "go_ids": ["GO:0007094", "GO:0007140", "GO:0008608", "GO:0043063", "GO:0051306"], "go_terms": ["GO:0007094:mitotic spindle assembly checkpoint signaling:P", "GO:0007140:male meiotic nuclear division:P", "GO:0008608:attachment of spindle microtubules to kinetochore:P", "GO:0043063:intercellular bridge organization:P", "GO:0051306:mitotic sister chromatid separation:P"], "name": "Tex14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039340": {"description": "Transcription factor Tfc4/TFIIIC-102/Sfc4", "go_ids": ["GO:0006383"], "go_terms": ["GO:0006383:transcription by RNA polymerase III:P"], "name": "Tfc4/TFIIIC-102/Sfc4", "pathway_ids": ["R-SPO-76061", "R-SCE-76066", "R-HSA-749476", "R-HSA-76061", "R-SPO-76066", "R-HSA-76066", "R-SCE-76061"], "pathways": ["R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR039341": {"description": "Cilia- and flagella-associated protein 99", "go_ids": [], "go_terms": [], "name": "CFAP99", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039342": {"description": "Protein TRIGALACTOSYLDIACYLGLYCEROL 2-like", "go_ids": [], "go_terms": [], "name": "TGD2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039343": {"description": "Protein NEOXANTHIN-DEFICIENT 1-like", "go_ids": [], "go_terms": [], "name": "NDX1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039344": {"description": "Metallo-beta-lactamase domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "MBLAC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039346": {"description": "Classical arabinogalactan protein 25/26", "go_ids": [], "go_terms": [], "name": "AGP25/26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039347": {"description": "Sperm mitochondrial-associated cysteine-rich protein", "go_ids": [], "go_terms": [], "name": "SMCP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039349": {"description": "Protein PLASTID REDOX INSENSITIVE 2", "go_ids": ["GO:0010468"], "go_terms": ["GO:0010468:regulation of gene expression:P"], "name": "PRIN2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039350": {"description": "Prospero homeodomain family", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Prospero_homeodomain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039351": {"description": "Keratin-associated protein 8-1", "go_ids": [], "go_terms": [], "name": "KRTAP8-1", "pathway_ids": ["R-MMU-6805567", "R-HSA-6805567"], "pathways": ["R-MMU-6805567:r:Keratinization", "R-HSA-6805567:r:Keratinization"], "type": "Family"}, "IPR039352": {"description": "Protein BEAN1", "go_ids": [], "go_terms": [], "name": "BEAN1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039353": {"description": "Transcription factor Adf-1", "go_ids": [], "go_terms": [], "name": "TF_Adf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039355": {"description": "Transcription factor GATA", "go_ids": ["GO:0006357", "GO:0003700"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "Transcription_factor_GATA", "pathway_ids": ["R-HSA-2032785", "R-HSA-8936459", "R-HSA-5689880", "R-CEL-8936459", "R-HSA-9925561", "R-GGA-9018519", "R-MMU-983231", "R-DRE-8939236", "R-BTA-983231", "R-RNO-8936459", "R-MMU-8939236", "R-HSA-5578768", "R-MMU-5689880", "R-GGA-8939236", "R-RNO-983231", "R-HSA-9823730", "R-DME-5683826", "R-DME-983231", "R-HSA-9616222", "R-HSA-9938206", "R-HSA-9690406", "R-HSA-9018519", "R-CFA-983231", "R-MMU-5683826", "R-HSA-400511", "R-DRE-9018519", "R-MMU-8936459", "R-HSA-9925563", "R-SPO-9018519", "R-HSA-9830364", "R-DME-9018519", "R-HSA-983231", "R-HSA-9937080", "R-DME-8939236", "R-HSA-6785807", "R-RNO-5683826", "R-RNO-8939236", "R-MMU-9018519", "R-CEL-5689880", "R-SCE-9018519", "R-GGA-983231", "R-DRE-983231", "R-DME-8936459", "R-HSA-5683826", "R-HSA-9733709", "R-CEL-9018519", "R-HSA-9758920", "R-HSA-8939236", "R-DME-5689880"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-GGA-9018519:r:Estrogen-dependent gene expression", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5578768:r:Physiological factors", "R-MMU-5689880:r:Ub-specific processing proteases", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9823730:r:Formation of definitive endoderm", "R-DME-5683826:r:Surfactant metabolism", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-CFA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9830364:r:Formation of the nephric duct", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-5683826:r:Surfactant metabolism", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-5689880:r:Ub-specific processing proteases", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-GGA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-9733709:r:Cardiogenesis", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-5689880:r:Ub-specific processing 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"PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR039370": {"description": "Transcription factor BTF3", "go_ids": [], "go_terms": [], "name": "BTF3", "pathway_ids": ["R-HSA-9918487"], "pathways": ["R-HSA-9918487:r:Dengue Virus Genome Translation and Replication"], "type": "Family"}, "IPR039373": {"description": "Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like", "go_ids": [], "go_terms": [], "name": "Peptidase_M28B", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-MMU-8856828", "R-MMU-9013106", "R-HSA-8856828", "R-SSC-9013408", "R-MMU-9013408", "R-RNO-9013149", "R-SSC-9013026", "R-MMU-9013404", "R-SSC-917977", "R-SPO-9013106", "R-SSC-9013407", "R-SCE-8980692", "R-SPO-9696273", "R-RNO-9013408", "R-RNO-9013406", "R-HSA-9013408", "R-RNO-9013404", "R-SCE-9696273", "R-RNO-917977", "R-SSC-432722", "R-RNO-432722", "R-SCE-8963693", "R-MMU-9013407", "R-RNO-8963693", "R-HSA-8963693", "R-RNO-9013407", "R-SSC-9013406", "R-RNO-9696273", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-917977", "R-MMU-9013406", "R-SSC-9013149", "R-MMU-8963693", "R-HSA-9013026", "R-HSA-917977", "R-HSA-9013407", "R-SSC-9013148", "R-SSC-9696270", "R-HSA-9725554", "R-SSC-9013404", "R-MMU-8856825", "R-RNO-9696270", "R-MMU-8980692", "R-MMU-432722", "R-RNO-8980692", "R-HSA-9013106", "R-SSC-8980692", "R-SPO-9013406", "R-HSA-9013423", "R-SCE-9013406", "R-HSA-9013148", "R-SSC-8856825", "R-RNO-9013106", "R-RNO-8856828", "R-HSA-432722", "R-CEL-8963693", "R-SPO-8963693", "R-RNO-8856825", "R-HSA-9696270", "R-SSC-9696273", "R-SSC-9013423", "R-SCE-9013106", "R-RNO-9013423", "R-SSC-8856828", "R-HSA-8856825", "R-MMU-9013026", "R-SSC-9013106", "R-HSA-9013406", "R-MMU-9696270", "R-MMU-9696273", "R-MMU-9013149", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-SSC-9013408:r:RHOG GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-SSC-9013026:r:RHOB GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-SSC-917977:r:Transferrin endocytosis and recycling", "R-SPO-9013106:r:RHOC GTPase cycle", "R-SSC-9013407:r:RHOH GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-SCE-9696273:r:RND1 GTPase cycle", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SSC-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-SSC-9696270:r:RND2 GTPase cycle", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SSC-8980692:r:RHOA GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-SPO-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SSC-9696273:r:RND1 GTPase cycle", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Family"}, "IPR039374": {"description": "Siderophore-interacting protein", "go_ids": [], "go_terms": [], "name": "SIP_fam", "pathway_ids": ["R-HSA-1222449", "R-HSA-9638334"], "pathways": ["R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-HSA-9638334:r:Iron assimilation using enterobactin"], "type": "Family"}, "IPR039383": {"description": "FHIT family", "go_ids": [], "go_terms": [], "name": "FHIT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039391": {"description": "Phytocyanin-like", "go_ids": ["GO:0009055"], "go_terms": ["GO:0009055:electron transfer activity:F"], "name": "Phytocyanin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039396": {"description": "Deltex, C-terminal", "go_ids": [], "go_terms": [], "name": "Deltex_C", "pathway_ids": ["PWY-7511", "R-DME-2122948", "R-HSA-3270619", "R-HSA-1606341", "R-MMU-3270619", "R-HSA-2122948", "R-HSA-3134975", "R-MMU-983168", "R-MMU-3134975", "R-MMU-2122948", "R-HSA-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR039398": {"description": "Deltex family", "go_ids": ["GO:0016567", "GO:0007219"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0007219:Notch signaling pathway:P"], "name": "Deltex_fam", "pathway_ids": ["PWY-7511", "R-DME-2122948", "R-HSA-3270619", "R-HSA-1606341", "R-MMU-3270619", "R-HSA-2122948", "R-HSA-3134975", "R-MMU-983168", "R-MMU-3134975", "R-MMU-2122948", "R-HSA-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR039399": {"description": "Deltex, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Deltex_C_sf", "pathway_ids": ["PWY-7511", "R-DME-2122948", "R-HSA-3270619", "R-HSA-1606341", "R-MMU-3270619", "R-HSA-2122948", "R-HSA-3134975", "R-MMU-983168", "R-MMU-3134975", "R-MMU-2122948", "R-HSA-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Homologous_superfamily"}, "IPR039411": {"description": "Ribosomal biogenesis NSA2 family", "go_ids": [], "go_terms": [], "name": "NSA2_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039420": {"description": "Transcriptional regulatory protein WalR-like", "go_ids": ["GO:0006355", "GO:0000976"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0000976:transcription cis-regulatory region binding:F"], "name": "WalR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039421": {"description": "Type 1 protein exporter", "go_ids": [], "go_terms": [], "name": "Type_1_exporter", "pathway_ids": ["R-HSA-5683371", "R-HSA-1989781", "R-DDI-983170", "R-SPO-382556", "R-RNO-983170", "R-DDI-382556", "R-HSA-1369007", "R-DDI-1369007", "R-HSA-9757110", "R-PFA-382556", "R-HSA-193368", "R-HSA-5678771", "R-RNO-382556", "R-HSA-1222449", "R-DDI-9757110", "R-DDI-9754706", "R-PFA-983170", "R-RNO-9757110", "R-SPO-9757110", "R-MMU-159418", "R-RNO-159418", "R-RNO-9754706", "R-DDI-193368", "R-HSA-5678520", "R-PFA-9754706", "R-SCE-1369007", "R-CFA-193368", "R-CFA-159418", "R-SPO-1369007", "R-SPO-983170", "R-CEL-1369007", "R-MMU-382556", "R-HSA-2564830", "R-SPO-159418", "R-SPO-9754706", "R-MMU-193368", "R-HSA-382556", "R-HSA-9760173", "R-HSA-2161517", "R-HSA-983170", "R-PFA-9757110", "R-HSA-9754706", "R-DDI-159418", "R-MMU-9754706", "R-MMU-1369007", "R-MMU-983170", "R-DRE-1369007", "R-RNO-193368", "R-HSA-1236974", "R-HSA-159418", "R-PFA-159418", "R-RNO-1369007", "R-SPO-193368", "R-PFA-193368", "R-MMU-9757110"], "pathways": ["R-HSA-5683371:r:Defective ABCB6 causes MCOPCB7", "R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-HSA-1369007:r:Mitochondrial ABC transporters", "R-DDI-1369007:r:Mitochondrial ABC transporters", "R-HSA-9757110:r:Prednisone ADME", "R-PFA-382556:r:ABC-family proteins mediated transport", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-5678771:r:Defective ABCB4 causes PFIC3, ICP3 and GBD1", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-1222449:r:Mtb iron assimilation by chelation", "R-DDI-9757110:r:Prednisone ADME", "R-DDI-9754706:r:Atorvastatin ADME", "R-PFA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-9757110:r:Prednisone ADME", "R-SPO-9757110:r:Prednisone ADME", "R-MMU-159418:r:Recycling of bile acids and salts", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-9754706:r:Atorvastatin ADME", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-5678520:r:Defective ABCB11 causes PFIC2 and BRIC2", "R-PFA-9754706:r:Atorvastatin ADME", "R-SCE-1369007:r:Mitochondrial ABC transporters", "R-CFA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-CFA-159418:r:Recycling of bile acids and salts", "R-SPO-1369007:r:Mitochondrial ABC transporters", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-1369007:r:Mitochondrial ABC transporters", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-SPO-159418:r:Recycling of bile acids and salts", "R-SPO-9754706:r:Atorvastatin ADME", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-2161517:r:Abacavir transmembrane transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-PFA-9757110:r:Prednisone ADME", "R-HSA-9754706:r:Atorvastatin ADME", "R-DDI-159418:r:Recycling of bile acids and salts", "R-MMU-9754706:r:Atorvastatin ADME", "R-MMU-1369007:r:Mitochondrial ABC transporters", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DRE-1369007:r:Mitochondrial ABC transporters", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-159418:r:Recycling of bile acids and salts", "R-PFA-159418:r:Recycling of bile acids and salts", "R-RNO-1369007:r:Mitochondrial ABC transporters", "R-SPO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-PFA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9757110:r:Prednisone ADME"], "type": "Family"}, "IPR039422": {"description": "Transcription regulators MarR/SlyA-like", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "MarR/SlyA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039424": {"description": "Solute-binding protein family 5", "go_ids": [], "go_terms": [], "name": "SBP_5", "pathway_ids": ["R-HSA-9927020", "R-HSA-1222538"], "pathways": ["R-HSA-9927020:r:Heme assimilation", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Family"}, "IPR039425": {"description": "RNA polymerase sigma-70-like", "go_ids": [], "go_terms": [], "name": "RNA_pol_sigma-70-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039426": {"description": "TonB-dependent receptor-like", "go_ids": [], "go_terms": [], "name": "TonB-dep_rcpt-like", "pathway_ids": ["R-HSA-9638334", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR039428": {"description": "NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like", "go_ids": [], "go_terms": [], "name": "NUOK/Mnh_C1-like", "pathway_ids": ["R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-GGA-5419276", "R-HSA-5419276", "R-RNO-5419276", "R-SSC-5419276", "R-DRE-5419276"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-GGA-5419276:r:Mitochondrial translation termination", "R-HSA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR039429": {"description": "Serine hydroxymethyltransferase-like domain", "go_ids": [], "go_terms": [], "name": "SHMT-like_dom", "pathway_ids": ["PWY-3661", "PWY-8363", "PWY-2201", "PWY-181", "PWY-1622", "PWY-8325", "PWY-2161", "PWY-5497", "PWY-8362", "PWY-3841", "R-MMU-9837999", "R-SCE-71262", "R-MMU-9013408", "R-HSA-196757", "R-BTA-9013408", "R-MMU-71262", "R-MMU-196757", "R-SPO-9837999", "R-SPO-71262", "R-BTA-9837999", "R-SCE-9837999", "R-BTA-196757", "R-CEL-71262", "R-HSA-9837999", "R-HSA-9013408", "R-SCE-196757", "R-SPO-196757", "R-HSA-71262", "R-CEL-196757"], "pathways": ["PWY-3661:t:glycine betaine degradation I", "PWY-8363:t:photorespiration III", "PWY-2201:t:folate transformations I", "PWY-181:t:photorespiration I", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-8325:t:glycine betaine degradation III", "PWY-2161:t:folate polyglutamylation", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8362:t:photorespiration II", "PWY-3841:t:folate transformations II (plants)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SCE-71262:r:Carnitine synthesis", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-196757:r:Metabolism of folate and pterines", "R-BTA-9013408:r:RHOG GTPase cycle", "R-MMU-71262:r:Carnitine synthesis", "R-MMU-196757:r:Metabolism of folate and pterines", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SPO-71262:r:Carnitine synthesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-196757:r:Metabolism of folate and pterines", "R-CEL-71262:r:Carnitine synthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-71262:r:Carnitine synthesis", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Domain"}, "IPR039430": {"description": "Thymidylate kinase-like domain", "go_ids": [], "go_terms": [], "name": "Thymidylate_kin-like_dom", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7184", "PWY-7187", "PWY-7210", "PWY-7197", "R-HSA-499943", "R-DRE-499943", "R-MMU-499943"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7187:t:pyrimidine deoxyribonucleotides de novo biosynthesis II", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7197:t:pyrimidine deoxyribonucleotide phosphorylation", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Domain"}, "IPR039431": {"description": "Vta1/callose synthase, N-terminal", "go_ids": [], "go_terms": [], "name": "Vta1/CALS_N", "pathway_ids": ["R-HSA-917729", "R-HSA-162588", "R-DDI-917729", "R-MMU-917729"], "pathways": ["R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Domain"}, "IPR039432": {"description": "SRP9 domain", "go_ids": [], "go_terms": [], "name": "SRP9_dom", "pathway_ids": ["R-HSA-1799339", "R-MMU-1799339", "R-DME-1799339", "R-DDI-1799339", "R-CEL-1799339", "R-SPO-1799339", "R-SCE-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Domain"}, "IPR039433": {"description": "Mff-like domain", "go_ids": [], "go_terms": [], "name": "Mff-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039434": {"description": "Rift valley fever virus non structural protein-like", "go_ids": [], "go_terms": [], "name": "NSs-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039436": {"description": "Asteroid domain", "go_ids": [], "go_terms": [], "name": "Asteroid_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039437": {"description": "Aldolase FrzH/putative lumazine-binding", "go_ids": [], "go_terms": [], "name": "FrzH/put_lumazine-bd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039438": {"description": "At2g23090-like, zinc-binding domain", "go_ids": [], "go_terms": [], "name": "At2g23090-like_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039439": {"description": "SH3b1 domain", "go_ids": [], "go_terms": [], "name": "SH3b1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039440": {"description": "Domain of unknown function DUF3850", "go_ids": [], "go_terms": [], "name": "DUF3850", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039442": {"description": "Mrr-like domain", "go_ids": [], "go_terms": [], "name": "Mrr-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039445": {"description": "Transcriptional regulator DauR-like, HTH domain", "go_ids": [], "go_terms": [], "name": "DauR-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039446": {"description": "Transcriptional regulator DauR-like", "go_ids": [], "go_terms": [], "name": "DauR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039447": {"description": "Urease accessory protein UreH-like, transmembrane domain", "go_ids": [], "go_terms": [], "name": "UreH-like_TM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039448": {"description": "Right handed beta helix domain", "go_ids": [], "go_terms": [], "name": "Beta_helix", "pathway_ids": ["R-MMU-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-DDI-418594", "R-DDI-420499", "R-DDI-977444", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-CEL-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-418594:r:G alpha (i) signalling events", "R-DDI-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-DDI-977444:r:GABA B receptor activation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR039449": {"description": "Type VI secretion system TssO", "go_ids": [], "go_terms": [], "name": "TssO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039451": {"description": "Family of unknown function DUF5419", "go_ids": [], "go_terms": [], "name": "DUF5419", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039452": {"description": "Protein of unknown function DUF5403", "go_ids": [], "go_terms": [], "name": "DUF5403", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039453": {"description": "Mitochondrial outer membrane protein OM14, C-terminal", "go_ids": [], "go_terms": [], "name": "OM14_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039454": {"description": "Mitochondrial outer membrane protein OM14", "go_ids": ["GO:0005741", "GO:1990593"], "go_terms": ["GO:0005741:mitochondrial outer membrane:C", "GO:1990593:nascent polypeptide-associated complex binding:F"], "name": "OM14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039455": {"description": "EPIDERMAL PATTERNING FACTOR-like protein", "go_ids": ["GO:0010374"], "go_terms": ["GO:0010374:stomatal complex development:P"], "name": "EPFL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039457": {"description": "Ly6/PLAUR domain-containing protein 6-like", "go_ids": ["GO:0030548"], "go_terms": ["GO:0030548:acetylcholine receptor regulator activity:F"], "name": "LYPD6-like", "pathway_ids": ["R-MMU-163125", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR039458": {"description": "FimA-like", "go_ids": ["GO:0007155"], "go_terms": ["GO:0007155:cell adhesion:P"], "name": "FimA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039459": {"description": "RepB-like DNA primase domain", "go_ids": [], "go_terms": [], "name": "RepB-like_DNA_primase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039460": {"description": "STAGA complex 65 subunit gamma/SAGA complex subunit Spt7", "go_ids": ["GO:0000124"], "go_terms": ["GO:0000124:SAGA complex:C"], "name": "SUPT7L/Spt7", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR039461": {"description": "Peptidase family M49", "go_ids": ["GO:0008239"], "go_terms": ["GO:0008239:dipeptidyl-peptidase activity:F"], "name": "Peptidase_M49", "pathway_ids": ["R-HSA-9755511", "R-HSA-8951664"], "pathways": ["R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation"], "type": "Family"}, "IPR039462": {"description": "Nucleoporin Nup159/Nup146, N-terminal", "go_ids": [], "go_terms": [], "name": "Nup159/Nup146_N", "pathway_ids": ["R-CEL-159231", "R-HSA-180910", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-MMU-3232142", "R-CEL-3301854", "R-CEL-159227", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-MMU-4085377", "R-MMU-4551638", "R-HSA-3371453", "R-CEL-159230", "R-HSA-165054", "R-CEL-3108214", "R-CEL-4551638", "R-HSA-4570464", "R-DME-4615885", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-MMU-3301854", "R-DME-4551638", "R-HSA-450520", "R-HSA-4085377", "R-HSA-168325", "R-MMU-450520", "R-MMU-170822", "R-HSA-9609690", "R-DME-159227", "R-DME-450520", "R-CEL-9615933", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-159230", "R-MMU-159227", "R-DME-9615933", "R-DME-3301854", "R-HSA-5619107", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-CEL-3371453", "R-CEL-159236"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-191859:r:snRNP Assembly", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-CEL-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-CEL-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR039464": {"description": "Gag-Pol polyprotein, Zinc-finger like domain", "go_ids": [], "go_terms": [], "name": "Gag-pol_Znf-H3C2", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR039465": {"description": "Interleukin-17 receptor-like", "go_ids": ["GO:0030368"], "go_terms": ["GO:0030368:interleukin-17 receptor activity:F"], "name": "IL-17_rcpt-like", "pathway_ids": ["R-HSA-448424", "R-MMU-5674135", "R-CEL-5674135", "R-HSA-9705671", "R-HSA-5674135", "R-DRE-5674135"], "pathways": ["R-HSA-448424:r:Interleukin-17 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-DRE-5674135:r:MAP2K and MAPK activation"], "type": "Family"}, "IPR039467": {"description": "Transcription factor TFIIIB component B'', Myb domain", "go_ids": [], "go_terms": [], "name": "TFIIIB_B''_Myb", "pathway_ids": ["R-HSA-76071", "R-SCE-76066", "R-SPO-76066", "R-HSA-76066", "R-HSA-76061", "R-MMU-76061", "R-SPO-76061", "R-MMU-76071", "R-MMU-76066", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR039468": {"description": "WDR19, WD40 repeat domain", "go_ids": [], "go_terms": [], "name": "WDR19_WD40_rpt", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-CEL-5620924", "R-CEL-5610787", "R-HSA-5610787", "R-MMU-5610787"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR039470": {"description": "Nucleoside 2-deoxyribosyltransferase-like", "go_ids": [], "go_terms": [], "name": "Nuc_deoxyri_tr2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039471": {"description": "Uncharacterized protein CXorf65-like", "go_ids": [], "go_terms": [], "name": "CXorf65-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039476": {"description": "Pyridinium-3,5-biscarboxylic acid mononucleotide synthase LarB-like", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "LarB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039477": {"description": "ILEI/PANDER domain", "go_ids": [], "go_terms": [], "name": "ILEI/PANDER_dom", "pathway_ids": ["R-DRE-114608", "R-RNO-8932506", "R-MMU-9939291", "R-HSA-8932504", "R-RNO-8932504", "R-MMU-2160916", "R-HSA-2160916", "R-RNO-114608", "R-HSA-114608", "R-BTA-114608", "R-HSA-8932506", "R-MMU-8932504", "R-HSA-9939291", "R-HSA-5083628", "R-RNO-9939291", "R-MMU-8932506", "R-MMU-114608"], "pathways": ["R-DRE-114608:r:Platelet degranulation", "R-RNO-8932506:r:DAG1 core M1 glycosylations", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-RNO-8932504:r:DAG1 core M2 glycosylations", "R-MMU-2160916:r:Hyaluronan degradation", "R-HSA-2160916:r:Hyaluronan degradation", "R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-5083628:r:Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "R-RNO-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-8932506:r:DAG1 core M1 glycosylations", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR039478": {"description": "Protein FAM184A/B, N-terminal", "go_ids": [], "go_terms": [], "name": "FAM184A/B_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039479": {"description": "Single CXXC unit", "go_ids": [], "go_terms": [], "name": "Mono-CXXC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039480": {"description": "C-C bond lyase-like", "go_ids": [], "go_terms": [], "name": "C-C_Bond_Lyase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039481": {"description": "Exocyst complex component EXOC2/Sec5, N-terminal domain", "go_ids": [], "go_terms": [], "name": "EXOC2/Sec5_N_dom", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-HSA-1445148", "R-MMU-264876", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-264876:r:Insulin processing", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Domain"}, "IPR039482": {"description": "Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, N-terminal", "go_ids": [], "go_terms": [], "name": "NYAP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039483": {"description": "Meiotic expression up-regulated protein 6, PH domain", "go_ids": [], "go_terms": [], "name": "Meu6_PH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039486": {"description": "Mug56/Spo71, PH domain", "go_ids": [], "go_terms": [], "name": "Mug56/Spo71_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039490": {"description": "Transmembrane protein 207", "go_ids": [], "go_terms": [], "name": "TMEM207", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039491": {"description": "Required for excision 1-B domain-containing protein", "go_ids": [], "go_terms": [], "name": "REX1-B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039492": {"description": "Transmembrane protein 109", "go_ids": ["GO:0071480"], "go_terms": ["GO:0071480:cellular response to gamma radiation:P"], "name": "TMEM109", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039493": {"description": "TMEM248/TMEM219", "go_ids": [], "go_terms": [], "name": "TMEM248/TMEM219", "pathway_ids": ["R-BTA-6803211", "R-MMU-6803211", "R-HSA-6803211"], "pathways": ["R-BTA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-MMU-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands"], "type": "Family"}, "IPR039494": {"description": "Factor VIII intron 22 protein", "go_ids": [], "go_terms": [], "name": "F8A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039495": {"description": "TATA box-binding protein-associated factor RNA polymerase I subunit A", "go_ids": ["GO:0006360", "GO:0000120"], "go_terms": ["GO:0006360:transcription by RNA polymerase I:P", "GO:0000120:RNA polymerase I transcription regulator complex:C"], "name": "TAF1A", "pathway_ids": ["R-MMU-5250924", "R-MMU-73762", "R-HSA-73772", "R-HSA-73863", "R-HSA-427359", "R-RNO-73772", "R-HSA-5250924", "R-MMU-73863", "R-HSA-427413", "R-MMU-73772", "R-RNO-5250924", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762"], "pathways": ["R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Family"}, "IPR039496": {"description": "CCDC92/74, N-terminal", "go_ids": [], "go_terms": [], "name": "CCDC92/74_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039497": {"description": "CCDC144C-like, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CC144C-like_CC_dom", "pathway_ids": ["R-HSA-9696270", "R-HSA-9035034", "R-HSA-9696273", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9927418", "R-HSA-9927426", "R-HSA-9696264"], "pathways": ["R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR039498": {"description": "Uncharacterised nucleotidyltransferase", "go_ids": [], "go_terms": [], "name": "NTP_transf_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039499": {"description": "Leucine rich adaptor protein 1/25", "go_ids": [], "go_terms": [], "name": "LURA1/LRA25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039500": {"description": "EVA1 domain", "go_ids": [], "go_terms": [], "name": "EVA1_dom", "pathway_ids": ["R-HSA-8957275", "R-HSA-381426"], "pathways": ["R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR039503": {"description": "BARD1, Zinc finger, RING-type", "go_ids": [], "go_terms": [], "name": "BARD1_Znf-RING", "pathway_ids": ["PWY-7511", "R-HSA-5689901", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5693565", "R-MMU-5689901", "R-MMU-6804756", "R-HSA-5693565", "R-MMU-5693616", "R-RNO-5689901", "R-MMU-5685938", "R-MMU-5693565", "R-MMU-69473", "R-RNO-5689603", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-5685938", "R-RNO-6804756", "R-MMU-5693568", "R-MMU-5689603", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9663199", "R-HSA-9701192", "R-RNO-5693579", "R-HSA-69473", "R-RNO-5693607", "R-MMU-5685942", "R-HSA-9709603", "R-RNO-5693571", "R-RNO-69473", "R-RNO-5685942", "R-HSA-5693571", "R-HSA-6804756", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-5689603", "R-HSA-5693554", "R-RNO-5693616", "R-HSA-5693579", "R-MMU-5693571", "R-HSA-9699150"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5689901:r:Metalloprotease DUBs", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-RNO-5689603:r:UCH proteinases", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5689603:r:UCH proteinases", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9663199:r:Defective DNA double strand break response due to BRCA1 loss of function", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9699150:r:Defective DNA double strand break response due to BARD1 loss of function"], "type": "Domain"}, "IPR039504": {"description": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EF hand domain", "go_ids": [], "go_terms": [], "name": "PLC-delta3_EF-hand", "pathway_ids": ["PWY-6367", "PWY-7039", "PWY-6351", "PWY-8052", "R-DRE-1855204", "R-HSA-1855204", "R-MMU-1855204"], "pathways": ["PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol"], "type": "Domain"}, "IPR039505": {"description": "Dynein regulatory complex protein 1/2, N-terminal", "go_ids": [], "go_terms": [], "name": "DRC1/2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039506": {"description": "SpoOB, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "SPOB_a", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039508": {"description": "Protein KASH5, EF-hand-like domain", "go_ids": [], "go_terms": [], "name": "KASH5_EF-hand-like_dom", "pathway_ids": ["R-DRE-6798695"], "pathways": ["R-DRE-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR039509": {"description": "SPATA31", "go_ids": [], "go_terms": [], "name": "SPATA31", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039510": {"description": "Vint domain", "go_ids": [], "go_terms": [], "name": "Vint_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039512": {"description": "RCHY1, zinc-ribbon", "go_ids": [], "go_terms": [], "name": "RCHY1_zinc-ribbon", "pathway_ids": ["PWY-7511", "R-HSA-110320", "R-MMU-110320", "R-HSA-983168", "R-HSA-9954709", "R-MMU-983168", "R-MMU-9954709"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR039513": {"description": "PL-6 family", "go_ids": [], "go_terms": [], "name": "PL-6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039514": {"description": "Endo-beta-1,6-galactanase-like", "go_ids": ["GO:0004553"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "6GAL-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039518": {"description": "WhiA, LAGLIDADG-like domain", "go_ids": [], "go_terms": [], "name": "WhiA_LAGLIDADG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039519": {"description": "YokE-like, PH domain", "go_ids": [], "go_terms": [], "name": "YokE-like_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039522": {"description": "Zinc-ribbon domain-containing protein-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Zn-ribbon_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039523": {"description": "Alpha-L-glutamate ligase-related protein, ATP-grasp domain", "go_ids": [], "go_terms": [], "name": "RimK-rel_E_lig_ATP-grasp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039524": {"description": "GPI ethanolamine phosphate transferase 3", "go_ids": ["GO:0006506", "GO:0016772"], "go_terms": ["GO:0006506:GPI anchor biosynthetic process:P", "GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "PIGO/GPI13", "pathway_ids": ["R-HSA-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR039525": {"description": "E3 ubiquitin-protein ligase RNF126-like, zinc-ribbon", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "RNF126-like_zinc-ribbon", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-DME-983168", "R-HSA-983168", "R-XTR-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR039527": {"description": "GPI ethanolamine phosphate transferase 2", "go_ids": ["GO:0051377", "GO:0006506"], "go_terms": ["GO:0051377:mannose-ethanolamine phosphotransferase activity:F", "GO:0006506:GPI anchor biosynthetic process:P"], "name": "PIGG/GPI7", "pathway_ids": ["R-SCE-162710", "R-HSA-162710"], "pathways": ["R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR039528": {"description": "DPM1-like", "go_ids": ["GO:0004582"], "go_terms": ["GO:0004582:dolichyl-phosphate beta-D-mannosyltransferase activity:F"], "name": "DPM1-like", "pathway_ids": ["PWY-7922", "PWY-7921", "PWY-7979", "PWY-7661", "R-MMU-162699", "R-HSA-162699", "R-DDI-162699", "R-HSA-4719360", "R-HSA-9918432", "R-HSA-4719377", "R-SPO-162699", "R-HSA-4717374", "R-SSC-162699", "R-DME-162699"], "pathways": ["PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-7979:t:protein O-mannosylation III (mammals, core M3)", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "R-MMU-162699:r:Synthesis of dolichyl-phosphate mannose", "R-HSA-162699:r:Synthesis of dolichyl-phosphate mannose", "R-DDI-162699:r:Synthesis of dolichyl-phosphate mannose", "R-HSA-4719360:r:Defective DPM3 causes DPM3-CDG", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-4719377:r:Defective DPM2 causes DPM2-CDG", "R-SPO-162699:r:Synthesis of dolichyl-phosphate mannose", "R-HSA-4717374:r:Defective DPM1 causes DPM1-CDG", "R-SSC-162699:r:Synthesis of dolichyl-phosphate mannose", "R-DME-162699:r:Synthesis of dolichyl-phosphate mannose"], "type": "Family"}, "IPR039529": {"description": "GPI inositol-deacylase", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "PGAP1/BST1", "pathway_ids": ["R-MMU-162791", "R-HSA-162791", "R-RNO-162791"], "pathways": ["R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-HSA-162791:r:Attachment of GPI anchor to uPAR", "R-RNO-162791:r:Attachment of GPI anchor to uPAR"], "type": "Family"}, "IPR039530": {"description": "RNA-directed RNA polymerase L methyltransferase domain, rhabdovirus", "go_ids": [], "go_terms": [], "name": "L_methyltransferase_rhabdo", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-9828721", "R-HSA-9833110", "R-HSA-9828806", "R-HSA-9820962", "R-HSA-9828642", "R-HSA-9834752", "R-HSA-9820960"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-9828642:r:Respiratory syncytial virus genome transcription", "R-HSA-9834752:r:Respiratory syncytial virus genome replication", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry"], "type": "Domain"}, "IPR039532": {"description": "Transcriptional regulator TetR, C-terminal, Firmicutes type", "go_ids": [], "go_terms": [], "name": "TetR_C_Firmicutes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039535": {"description": "Arylsulfate sulfotransferase Cpz4-like", "go_ids": [], "go_terms": [], "name": "Cpz4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039536": {"description": "Transcriptional regulator TetR, C-terminal, Proteobacteria type", "go_ids": [], "go_terms": [], "name": "TetR_C_Proteobacteria", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039537": {"description": "Retrotransposon Ty1/copia-like", "go_ids": [], "go_terms": [], "name": "Retrotran_Ty1/copia-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039538": {"description": "BetI-type transcriptional repressor, C-terminal", "go_ids": [], "go_terms": [], "name": "BetI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039539": {"description": "Ras GTPase-activating protein-binding protein", "go_ids": [], "go_terms": [], "name": "Ras_GTPase_bind_prot", "pathway_ids": ["R-HSA-9705671"], "pathways": ["R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses"], "type": "Family"}, "IPR039540": {"description": "UBL3-like, ubiquitin domain", "go_ids": [], "go_terms": [], "name": "UBL3-like_ubiquitin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039542": {"description": "Endoplasmic reticulum vesicle transporter, N-terminal", "go_ids": [], "go_terms": [], "name": "Erv_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039544": {"description": "Tim44-like", "go_ids": [], "go_terms": [], "name": "Tim44-like", "pathway_ids": ["R-HSA-1268020"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR039545": {"description": "Post-GPI attachment to proteins factor 2", "go_ids": ["GO:0000139"], "go_terms": ["GO:0000139:Golgi membrane:C"], "name": "PGAP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039547": {"description": "Large ribosomal subunit protein eL19", "go_ids": ["GO:0003723", "GO:0003735", "GO:0022625"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0003735:structural constituent of ribosome:F", "GO:0022625:cytosolic large ribosomal subunit:C"], "name": "Ribosomal_eL19", 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degrades nascent peptide", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-CFA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit"], "type": "Family"}, "IPR039551": {"description": "Choline/Carnitine o-acyltransferase, domain 1 and 2", "go_ids": [], "go_terms": [], "name": "Cho/carn_acyl_trans_1_2", "pathway_ids": ["R-HSA-1989781", "R-SSC-264642", "R-DRE-200425", "R-DRE-1483191", "R-MMU-200425", "R-RNO-1483191", "R-MMU-1483191", "R-HSA-389887", "R-HSA-264642", "R-MMU-9033241", "R-XTR-200425", "R-DME-264642", "R-MMU-264642", "R-BTA-9033241", "R-CEL-1483191", "R-RNO-9033241", "R-HSA-1483191", "R-MMU-389887", "R-SCE-389887", "R-DRE-264642", "R-RNO-389887", "R-HSA-200425", "R-RNO-264642", "R-RNO-200425", "R-HSA-9933387", "R-SCE-264642", "R-SCE-9033241", "R-BTA-200425", "R-SCE-1483191", "R-DME-1483191", "R-HSA-9033241", "R-CEL-264642", "R-BTA-389887", "R-SSC-1483191"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-SSC-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DRE-200425:r:Carnitine shuttle", "R-DRE-1483191:r:Synthesis of PC", "R-MMU-200425:r:Carnitine shuttle", "R-RNO-1483191:r:Synthesis of PC", "R-MMU-1483191:r:Synthesis of PC", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-9033241:r:Peroxisomal protein import", "R-XTR-200425:r:Carnitine shuttle", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-9033241:r:Peroxisomal protein import", "R-CEL-1483191:r:Synthesis of PC", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-1483191:r:Synthesis of PC", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DRE-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-200425:r:Carnitine shuttle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-SCE-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SCE-9033241:r:Peroxisomal protein import", "R-BTA-200425:r:Carnitine shuttle", "R-SCE-1483191:r:Synthesis of PC", "R-DME-1483191:r:Synthesis of PC", "R-HSA-9033241:r:Peroxisomal protein import", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SSC-1483191:r:Synthesis of PC"], "type": "Domain"}, "IPR039552": {"description": "Transposase IS66, C-terminal", "go_ids": [], "go_terms": [], "name": "IS66_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039553": {"description": "Prefoldin-like", "go_ids": [], "go_terms": [], "name": "Prefoldin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039554": {"description": "HigA2-like, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "HigA2-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039555": {"description": "F plasmid transfer operon protein", "go_ids": [], "go_terms": [], "name": "TraF/TrbB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039558": {"description": "Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TPA1/OFD1_N", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-HSA-9629569", "R-DME-9629569", "R-MMU-9629569", "R-BTA-9629569", "R-SCE-9629569", "R-SPO-9629569"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-HSA-9629569:r:Protein hydroxylation", "R-DME-9629569:r:Protein hydroxylation", "R-MMU-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-SCE-9629569:r:Protein hydroxylation", "R-SPO-9629569:r:Protein hydroxylation"], "type": "Domain"}, "IPR039560": {"description": "Potyviral polyprotein protein 3", "go_ids": [], "go_terms": [], "name": "Potyvirid-P3", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR039561": {"description": "Peptidase M15C", "go_ids": ["GO:0008233"], "go_terms": ["GO:0008233:peptidase activity:F"], "name": "Peptidase_M15C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039564": {"description": "Peptidase C39-like", "go_ids": [], "go_terms": [], "name": "Peptidase_C39-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039565": {"description": "Outer membrane lipoprotein BamD-like", "go_ids": [], "go_terms": [], "name": "BamD-like", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR039566": {"description": "Conserved virulence factor B, first S1 domain", "go_ids": [], "go_terms": [], "name": "CvfB_S1_st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039567": {"description": "FluMu protein gp42, glycine zipper domain", "go_ids": [], "go_terms": [], "name": "Gly-zipper", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039568": {"description": "Peptidase MA-like domain", "go_ids": [], "go_terms": [], "name": "Peptidase_MA-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039569": {"description": "FAS1-like, dehydratase domain region", "go_ids": [], "go_terms": [], "name": "FAS1-like_DH_region", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039573": {"description": "NS2A-like", "go_ids": [], "go_terms": [], "name": "NS2A-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039574": {"description": "Opioid growth factor receptor", "go_ids": ["GO:0140625"], "go_terms": ["GO:0140625:opioid growth factor receptor activity:F"], "name": "OGFr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039575": {"description": "Prolyl 3-hydroxylase", "go_ids": ["GO:0032963"], "go_terms": ["GO:0032963:collagen metabolic process:P"], "name": "P3H", "pathway_ids": ["PWY-7894", "R-RNO-1650814", "R-MMU-1650814", "R-HSA-1650814", "R-GGA-1650814"], "pathways": ["PWY-7894:t:procollagen hydroxylation and glycosylation", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-GGA-1650814:r:Collagen biosynthesis and modifying enzymes"], "type": "Family"}, "IPR039576": {"description": "Amyloid beta precursor protein binding family B member 1/2/3", "go_ids": ["GO:0001540"], "go_terms": ["GO:0001540:amyloid-beta binding:F"], "name": "APBB1/2/3", "pathway_ids": ["R-MMU-5693565", "R-HSA-5693565", "R-RNO-5693565"], "pathways": ["R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Family"}, "IPR039577": {"description": "E3 ubiquitin-protein ligase Rad18", "go_ids": ["GO:0006301", "GO:0006513", "GO:0061630", "GO:0003697"], "go_terms": ["GO:0006301:DNA damage tolerance:P", "GO:0006513:protein monoubiquitination:P", "GO:0061630:ubiquitin protein ligase activity:F", "GO:0003697:single-stranded DNA binding:F"], "name": "Rad18", "pathway_ids": ["PWY-7511", "R-HSA-8866654", "R-MMU-8866654", "R-SPO-110314", "R-HSA-110314", "R-MMU-110314"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex"], "type": "Family"}, "IPR039578": {"description": "Oncostatin-M", "go_ids": ["GO:0005125", "GO:0005147", "GO:0038165"], "go_terms": ["GO:0005125:cytokine activity:F", "GO:0005147:oncostatin-M receptor binding:F", "GO:0038165:oncostatin-M-mediated signaling pathway:P"], "name": "OSM", "pathway_ids": ["R-MMU-6788467", "R-RNO-6788467", "R-HSA-6788467", "R-HSA-6785807"], "pathways": ["R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling"], "type": "Family"}, "IPR039579": {"description": "Arginine vasopressin-induced protein 1", "go_ids": [], "go_terms": [], "name": "AVPI1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039580": {"description": "Transcriptional and immune response regulator", "go_ids": [], "go_terms": [], "name": "Tcim", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039581": {"description": "Fibronectin type III domain-containing protein 11", "go_ids": [], "go_terms": [], "name": "FNDC11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039582": {"description": "Thiamine-triphosphatase", "go_ids": ["GO:0050333"], "go_terms": ["GO:0050333:thiamine triphosphate phosphatase activity:F"], "name": "THTPA", "pathway_ids": ["PWY-7369", "R-RNO-196819", "R-HSA-196819", "R-MMU-196819", "R-BTA-196819"], "pathways": ["PWY-7369:t:thiamine triphosphate metabolism", "R-RNO-196819:r:Vitamin B1 (thiamin) metabolism", "R-HSA-196819:r:Vitamin B1 (thiamin) metabolism", "R-MMU-196819:r:Vitamin B1 (thiamin) metabolism", "R-BTA-196819:r:Vitamin B1 (thiamin) metabolism"], "type": "Family"}, "IPR039583": {"description": "Transcription factor-like 5/SOLH1/2", "go_ids": ["GO:0007283", "GO:0006355", "GO:0003700"], "go_terms": ["GO:0007283:spermatogenesis:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "TCFL5/SOLH1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039584": {"description": "Heat shock factor 2-binding protein", "go_ids": [], "go_terms": [], "name": "HSF2BP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039585": {"description": "SERTA domain-containing protein 3", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "SERTAD3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039586": {"description": "Cilia- and flagella-associated protein 46", "go_ids": ["GO:0035082", "GO:0060294"], "go_terms": ["GO:0035082:axoneme assembly:P", "GO:0060294:cilium movement involved in cell motility:P"], "name": "CFAP46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039587": {"description": "TMEM248/TMEM219 domain", "go_ids": [], "go_terms": [], "name": "TMEM248/TMEM219_dom", "pathway_ids": ["R-BTA-6803211", "R-MMU-6803211", "R-HSA-6803211"], "pathways": ["R-BTA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-MMU-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands"], "type": "Domain"}, "IPR039588": {"description": "F-box only protein 4", "go_ids": ["GO:0031146"], "go_terms": ["GO:0031146:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process:P"], "name": "FBXO4", "pathway_ids": ["R-BTA-983168", "R-MMU-8951664", "R-BTA-8951664", "R-HSA-983168", "R-HSA-390471", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR039589": {"description": "TBCC domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "TBCC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039590": {"description": "Developmental pluripotency-associated protein 2/4", "go_ids": ["GO:0003682"], "go_terms": ["GO:0003682:chromatin binding:F"], "name": "Dppa2/4", "pathway_ids": ["R-HSA-9819196", "R-HSA-2892247"], "pathways": ["R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "type": "Family"}, "IPR039591": {"description": "AP-5 complex subunit mu-1", "go_ids": [], "go_terms": [], "name": "AP5M1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039594": {"description": "F-box only protein 34/46", "go_ids": [], "go_terms": [], "name": "FBXO34/46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039595": {"description": "TE2IP/Rap1", "go_ids": ["GO:0000723"], "go_terms": ["GO:0000723:telomere maintenance:P"], "name": "TE2IP/Rap1", "pathway_ids": ["R-BTA-174411", "R-MMU-174430", "R-RNO-174437", "R-HSA-174414", "R-MMU-174417", "R-BTA-174437", "R-XTR-171319", "R-BTA-174417", "R-HSA-1221632", "R-RNO-171319", "R-MMU-110331", "R-MMU-9670095", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-XTR-110330", "R-MMU-174414", "R-BTA-174430", "R-DRE-110331", "R-DRE-174430", "R-RNO-110330", "R-MMU-174437", "R-XTR-2559586", "R-HSA-110329", "R-HSA-110330", "R-BTA-110330", "R-RNO-174411", "R-BTA-9670095", "R-RNO-2559586", "R-MMU-110330", "R-HSA-171306", "R-DRE-110330", "R-MMU-2559586", "R-RNO-174430", "R-BTA-171306", "R-RNO-110331", "R-HSA-174430", "R-HSA-110328", "R-DRE-171319", "R-HSA-174411", "R-DRE-174437", "R-XTR-110331", "R-MMU-171319", "R-BTA-171319", "R-BTA-2559586", "R-XTR-171306", "R-HSA-9670095", "R-BTA-110331", "R-GGA-418124", "R-RNO-174417", "R-BTA-174414", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586", "R-RNO-174414"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-171319:r:Telomere Extension By Telomerase", "R-BTA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-1221632:r:Meiotic synapsis", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-XTR-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-DRE-110331:r:Cleavage of the damaged purine", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-RNO-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-BTA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-9670095:r:Inhibition of DNA recombination at telomere", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-DRE-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-BTA-171306:r:Packaging Of Telomere Ends", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DRE-174437:r:Removal of the Flap Intermediate from the C-strand", "R-XTR-110331:r:Cleavage of the damaged purine", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-BTA-171319:r:Telomere Extension By Telomerase", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-XTR-171306:r:Packaging Of Telomere Ends", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-BTA-110331:r:Cleavage of the damaged purine", "R-GGA-418124:r:Telomere maintenance", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere"], "type": "Family"}, "IPR039596": {"description": "Growth arrest-specific protein 1", "go_ids": ["GO:0051726"], "go_terms": ["GO:0051726:regulation of cell cycle:P"], "name": "GAS1", "pathway_ids": ["R-MMU-5635838", "R-HSA-5635838", "R-MMU-5632681", "R-HSA-5632681"], "pathways": ["R-MMU-5635838:r:Activation of SMO", "R-HSA-5635838:r:Activation of SMO", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-5632681:r:Ligand-receptor interactions"], "type": "Family"}, "IPR039598": {"description": "HMG domain-containing protein 3", "go_ids": [], "go_terms": [], "name": "HMGXB3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039599": {"description": "RNA-binding protein 48", "go_ids": [], "go_terms": [], "name": "RBM48", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039600": {"description": "TANGO6/Rtp1", "go_ids": [], "go_terms": [], "name": "TANGO6/Rtp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039601": {"description": "RNA polymerase I-specific transcription initiation factor Rrn5", "go_ids": ["GO:0000500", "GO:0042790"], "go_terms": ["GO:0000500:RNA polymerase I upstream activating factor complex:C", "GO:0042790:nucleolar large rRNA transcription by RNA polymerase I:P"], "name": "Rrn5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039602": {"description": "Transcriptional regulatory protein Rxt2", "go_ids": [], "go_terms": [], "name": "Rxt2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039603": {"description": "Small ribosomal subunit protein mS41", "go_ids": [], "go_terms": [], "name": "Ribosomal_mS41", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039604": {"description": "Nuclear segregation protein Bfr1", "go_ids": [], "go_terms": [], "name": "Bfr1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039605": {"description": "AT-hook motif nuclear-localized protein", "go_ids": ["GO:0003680"], "go_terms": ["GO:0003680:minor groove of adenine-thymine-rich DNA binding:F"], "name": "AHL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039606": {"description": "Phytol/farnesol kinase", "go_ids": ["GO:0016301"], "go_terms": ["GO:0016301:kinase activity:F"], "name": "Phytol/farnesol_kinase", "pathway_ids": ["PWY-5107"], "pathways": ["PWY-5107:t:phytol salvage pathway"], "type": "Family"}, "IPR039607": {"description": "VQ motif-containing protein 8/17/18/20/21/25", "go_ids": [], "go_terms": [], "name": "VQ_8/17/18/20/21/25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039608": {"description": "VQ motif-containing protein 1/10", "go_ids": [], "go_terms": [], "name": "VQ_1/10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039609": {"description": "VQ motif-containing protein 15/22", "go_ids": [], "go_terms": [], "name": "VQ_15/22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039610": {"description": "VQ motif-containing protein 29", "go_ids": [], "go_terms": [], "name": "VQ29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039611": {"description": "VQ motif-containing protein 4/11/13/19/31/33", "go_ids": [], "go_terms": [], "name": "VQ_4/11/13/19/31/33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039612": {"description": "VQ motif-containing protein 5/9/14", "go_ids": [], "go_terms": [], "name": "VQ_5/9/14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039613": {"description": "Protein SPIRAL1-like", "go_ids": ["GO:0043622"], "go_terms": ["GO:0043622:cortical microtubule organization:P"], "name": "SPR1/2/3/4/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039614": {"description": "Protein PLASTID MOVEMENT IMPAIRED 1-like", "go_ids": [], "go_terms": [], "name": "PMI1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039615": {"description": "Protein PHYTOCHROME KINASE SUBSTRATE", "go_ids": ["GO:0009638"], "go_terms": ["GO:0009638:phototropism:P"], "name": "PKS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039616": {"description": "CLAVATA3/ESR (CLE)-related protein 1-4", "go_ids": [], "go_terms": [], "name": "CLE1-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039617": {"description": "CLAVATA3/ESR (CLE)-related protein, eukaryotic", "go_ids": [], "go_terms": [], "name": "CLAVATA3-CLE_euk", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039618": {"description": "CLAVATA3/ESR (CLE)-related protein 9-13", "go_ids": [], "go_terms": [], "name": "CLE9-13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039619": {"description": "Membrane-associated kinase regulator 2/5", "go_ids": ["GO:0005886"], "go_terms": ["GO:0005886:plasma membrane:C"], "name": "MAKR2/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039620": {"description": "BKI1/Probable membrane-associated kinase regulator 1/3/4", "go_ids": ["GO:0005886", "GO:0019210"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0019210:kinase inhibitor activity:F"], "name": "BKI1/MAKR1/3/4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039621": {"description": "Protein BIG GRAIN 1-like", "go_ids": ["GO:0009734"], "go_terms": ["GO:0009734:auxin-activated signaling pathway:P"], "name": "BG1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039622": {"description": "Methyl-CpG-binding domain-containing protein 10/11", "go_ids": [], "go_terms": [], "name": "MBD10/11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039624": {"description": "Late embryogenesis abundant protein 1/2/D7/Stress-induced protein KIN2", "go_ids": [], "go_terms": [], "name": "LEA1/2/D7/KIN2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039625": {"description": "Transmembrane protein 178A/B", "go_ids": [], "go_terms": [], "name": "T178A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039627": {"description": "Mitochondrial escape protein 2", "go_ids": ["GO:0005743"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C"], "name": "Yme2_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039628": {"description": "PILR alpha-associated neural protein", "go_ids": ["GO:0050776"], "go_terms": ["GO:0050776:regulation of immune response:P"], "name": "PIANP", "pathway_ids": ["R-RNO-198933", "R-HSA-198933", "R-MMU-198933"], "pathways": ["R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR039629": {"description": "R3H domain-containing protein 4", "go_ids": [], "go_terms": [], "name": "R3HDM4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039630": {"description": "Protein FAM149", "go_ids": [], "go_terms": [], "name": "FAM149", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039631": {"description": "Leucine-rich repeat-containing protein 42", "go_ids": [], "go_terms": [], "name": "LRRC42", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039632": {"description": "Transmembrane protein 42", "go_ids": [], "go_terms": [], "name": "TMEM42", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039633": {"description": "Plastid-lipid-associated protein", "go_ids": [], "go_terms": [], "name": "PAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039634": {"description": "Bul1-like", "go_ids": [], "go_terms": [], "name": "Bul1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039635": {"description": "Endoplasmic reticulum membrane-associated RNA degradation protein", "go_ids": [], "go_terms": [], "name": "ERMARD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039637": {"description": "CCR4-NOT transcription complex subunit 7/8/Pop2", "go_ids": ["GO:0030014", "GO:0004535"], "go_terms": ["GO:0030014:CCR4-NOT complex:C", "GO:0004535:poly(A)-specific ribonuclease activity:F"], "name": "CNOT7/CNOT8/Pop2", "pathway_ids": ["R-HSA-6804115", "R-MMU-429947", "R-BTA-429947", "R-HSA-429947", "R-HSA-9820841", "R-MMU-6804115", "R-GGA-6804115", "R-DRE-6804115", "R-BTA-6804115", "R-GGA-429947"], "pathways": ["R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-BTA-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-GGA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-GGA-429947:r:Deadenylation of mRNA"], "type": "Family"}, "IPR039638": {"description": "Mediator of RNA polymerase II transcription subunit 33A/B", "go_ids": ["GO:2000762", "GO:0016592"], "go_terms": ["GO:2000762:regulation of phenylpropanoid metabolic process:P", "GO:0016592:mediator complex:C"], "name": "MED33A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039639": {"description": "Protein IDA-like", "go_ids": ["GO:0010227"], "go_terms": ["GO:0010227:floral organ abscission:P"], "name": "IDA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039640": {"description": "Stomatal closure-related actin-binding protein", "go_ids": ["GO:0003779", "GO:0010119", "GO:0007015"], "go_terms": ["GO:0003779:actin binding:F", "GO:0010119:regulation of stomatal movement:P", "GO:0007015:actin filament organization:P"], "name": "SCAB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039641": {"description": "Low-molecular-weight cysteine-rich protein", "go_ids": [], "go_terms": [], "name": "LCR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039643": {"description": "Dihydroxyacetone kinase phosphotransferase subunit DhaM", "go_ids": ["GO:0047324", "GO:0019563"], "go_terms": ["GO:0047324:phosphoenolpyruvate-glycerone phosphotransferase activity:F", "GO:0019563:glycerol catabolic process:P"], "name": "DhaM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039646": {"description": "Zinc finger HIT domain-containing protein 2", "go_ids": [], "go_terms": [], "name": "ZNHIT2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039647": {"description": "EF-hand domain pair protein CML-like", "go_ids": ["GO:0005509"], "go_terms": ["GO:0005509:calcium ion binding:F"], "name": "EF_hand_pair_protein_CML-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039648": {"description": "Pyridine nucleotide-disulphide oxidoreductase, N-terminal", "go_ids": [], "go_terms": [], "name": "DHPH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039650": {"description": "H(2):CoB-CoM heterodisulfide,ferredoxin reductase subunit A-like", "go_ids": [], "go_terms": [], "name": "HdrA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039651": {"description": "Protein FixC-like", "go_ids": [], "go_terms": [], "name": "FixC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039652": {"description": "Coatomer subunit zeta", "go_ids": ["GO:0006890", "GO:0030126"], "go_terms": ["GO:0006890:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum:P", "GO:0030126:COPI vesicle coat:C"], "name": "Coatomer_zeta", "pathway_ids": ["R-SPO-6807878", "R-BTA-6807878", "R-HSA-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-DDI-6807878", "R-BTA-6811434", "R-SPO-6811434", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-DDI-6811434", "R-CEL-6811434", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR039653": {"description": "Prenyltransferase", "go_ids": [], "go_terms": [], "name": "Prenyltransferase", "pathway_ids": ["PWY-5870", "PWY-5873", "PWY-6978", "PWY-5871", "PWY-5856", "PWY-6708", "PWY-5857", "PWY-7230", "PWY-5872", "PWY-5855", "R-SPO-2142789", "R-SCE-2142789", "R-DME-1268020", "R-DDI-1268020", "R-HSA-1268020", "R-DDI-2142789", "R-MMU-1268020", "R-HSA-2142789", "R-RNO-2142789", "R-CEL-1268020", "R-MMU-2142789", "R-DME-2142789", "R-CEL-2142789", "R-RNO-1268020"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)", "R-SPO-2142789:r:Ubiquinol biosynthesis", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-DME-1268020:r:Mitochondrial protein import", "R-DDI-1268020:r:Mitochondrial protein import", "R-HSA-1268020:r:Mitochondrial protein import", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-MMU-1268020:r:Mitochondrial protein import", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-CEL-1268020:r:Mitochondrial protein import", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis", "R-CEL-2142789:r:Ubiquinol biosynthesis", "R-RNO-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR039655": {"description": "HMG box-containing protein 1", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "HBP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039656": {"description": "Synergin gamma", "go_ids": [], "go_terms": [], "name": "SYNRG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039657": {"description": "Dimethylallyltransferase", "go_ids": [], "go_terms": [], "name": "Dimethylallyltransferase", "pathway_ids": ["PWY-2781", "R-HSA-6782315", "R-HSA-6787450"], "pathways": ["PWY-2781:t:cis-zeatin biosynthesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Family"}, 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"R-SSC-1433557", "R-RNO-186763", "R-HSA-9696273", "R-HSA-9656223"], "pathways": ["R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-9607240:r:FLT3 Signaling", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-BTA-9696273:r:RND1 GTPase cycle", "R-SSC-9607240:r:FLT3 Signaling", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-9607240:r:FLT3 Signaling", "R-RNO-74749:r:Signal attenuation", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-BTA-186763:r:Downstream signal transduction", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-8853659:r:RET signaling", "R-BTA-8853659:r:RET signaling", "R-HSA-9649948:r:Signaling 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Integrins", "R-RNO-9696273:r:RND1 GTPase cycle", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-74749:r:Signal attenuation", "R-DRE-354192:r:Integrin signaling", "R-RNO-74713:r:IRS activation", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-SSC-74713:r:IRS activation", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-210993:r:Tie2 Signaling", "R-SSC-74751:r:Insulin receptor signalling cascade", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-74749:r:Signal attenuation", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Family"}, "IPR039669": {"description": "TRAF family member-associated NF-kappa-B activator", "go_ids": ["GO:0043124"], "go_terms": ["GO:0043124:negative regulation of canonical NF-kappaB signal transduction:P"], "name": "TANK", "pathway_ids": ["R-HSA-9824878", "R-HSA-933541", "R-HSA-936964", "R-HSA-9013973", "R-HSA-9828211", "R-MMU-9824878", "R-MMU-936964"], "pathways": ["R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "type": "Family"}, "IPR039670": {"description": "Sterol transport protein NPC2-like", "go_ids": ["GO:0015918", "GO:0032934"], "go_terms": ["GO:0015918:sterol transport:P", "GO:0032934:sterol binding:F"], "name": "NPC2-like", "pathway_ids": ["R-SSC-8964038", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-8964038", "R-SSC-6798695", "R-SPO-6798695", "R-BTA-8964038", "R-DRE-6798695", "R-CEL-8964038", "R-DRE-8964038", "R-MMU-8964038", "R-CEL-6798695", "R-SCE-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-DDI-8964038", "R-SCE-8964038", "R-HSA-8964038"], "pathways": ["R-SSC-8964038:r:LDL clearance", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-8964038:r:LDL clearance", "R-SSC-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-8964038:r:LDL clearance", "R-DRE-6798695:r:Neutrophil degranulation", "R-CEL-8964038:r:LDL clearance", "R-DRE-8964038:r:LDL clearance", "R-MMU-8964038:r:LDL clearance", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-8964038:r:LDL clearance", "R-SCE-8964038:r:LDL clearance", "R-HSA-8964038:r:LDL clearance"], "type": "Family"}, "IPR039671": {"description": "Protein THEMIS", "go_ids": [], "go_terms": [], "name": "THEMIS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039672": {"description": "Lactose permease-like", "go_ids": ["GO:0015293", "GO:0008643", "GO:0016020"], "go_terms": ["GO:0015293:symporter activity:F", "GO:0008643:carbohydrate transport:P", "GO:0016020:membrane:C"], "name": "MFS_2", "pathway_ids": ["R-HSA-1483191", "R-GGA-1483191", "R-HSA-1660661", "R-DRE-1483191", "R-XTR-1483191", "R-XTR-1660661", "R-MMU-1483191", "R-MMU-1660661"], "pathways": ["R-HSA-1483191:r:Synthesis of PC", "R-GGA-1483191:r:Synthesis of PC", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-DRE-1483191:r:Synthesis of PC", "R-XTR-1483191:r:Synthesis of PC", "R-XTR-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1483191:r:Synthesis of PC", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR039673": {"description": "DNA-binding protein SATB1/SATB2", "go_ids": ["GO:0006338", "GO:0003677"], "go_terms": ["GO:0006338:chromatin remodeling:P", "GO:0003677:DNA binding:F"], "name": "SATB1/SATB2", "pathway_ids": ["R-MMU-4551638", "R-MMU-111465", "R-HSA-4551638", "R-HSA-8940973", "R-CEL-4551638", "R-HSA-111465"], "pathways": ["R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-CEL-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Family"}, "IPR039674": {"description": "CASP8-associated protein 2", "go_ids": ["GO:0097190"], "go_terms": ["GO:0097190:apoptotic signaling pathway:P"], "name": "FLASH", "pathway_ids": ["R-MMU-3899300", "R-HSA-3899300"], "pathways": ["R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-3899300:r:SUMOylation of transcription cofactors"], "type": "Family"}, "IPR039675": {"description": "Cartilage intermediate layer protein 1/2", "go_ids": [], "go_terms": [], "name": "CILP1/CILP2", "pathway_ids": ["R-MMU-2404192", "R-HSA-2404192"], "pathways": ["R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "type": "Family"}, "IPR039676": {"description": "Acyloxyacyl hydrolase", "go_ids": ["GO:0050528"], "go_terms": ["GO:0050528:acyloxyacyl hydrolase activity:F"], "name": "AOAH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039677": {"description": "Ciliogenesis and planar polarity effector 2", "go_ids": ["GO:0003924"], "go_terms": ["GO:0003924:GTPase activity:F"], "name": "RSG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039678": {"description": "Beta-catenin-like protein 1", "go_ids": [], "go_terms": [], "name": "CTNNBL1", "pathway_ids": ["R-HSA-72163", "R-RNO-72163", "R-SPO-72163", "R-HSA-9918481", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039679": {"description": "Nuclear receptor-binding factor 2", "go_ids": ["GO:0006914"], "go_terms": ["GO:0006914:autophagy:P"], "name": "NRBF2", "pathway_ids": ["R-RNO-383280", "R-MMU-383280", "R-HSA-383280"], "pathways": ["R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-HSA-383280:r:Nuclear Receptor transcription pathway"], "type": "Family"}, "IPR039680": {"description": "Pleckstrin homology domain-containing family B member 1/2", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "PLEKHB1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039681": {"description": "Interleukin-18-binding protein", "go_ids": ["GO:0042007"], "go_terms": ["GO:0042007:interleukin-18 binding:F"], "name": "IL18BP", "pathway_ids": ["R-HSA-9008059", "R-HSA-9012546", "R-MMU-9012546"], "pathways": ["R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-9012546:r:Interleukin-18 signaling", "R-MMU-9012546:r:Interleukin-18 signaling"], "type": "Family"}, "IPR039682": {"description": "Exocyst complex component Sec8/EXOC4", "go_ids": ["GO:0006893", "GO:0000145"], "go_terms": ["GO:0006893:Golgi to plasma membrane transport:P", "GO:0000145:exocyst:C"], "name": "Sec8/EXOC4", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Family"}, "IPR039683": {"description": "Protein Lsm12-like", "go_ids": [], "go_terms": [], "name": "Lsm12-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039684": {"description": "Fanconi anemia group G protein", "go_ids": ["GO:0036297", "GO:0043240"], "go_terms": ["GO:0036297:interstrand cross-link repair:P", "GO:0043240:Fanconi anaemia nuclear complex:C"], "name": "FANCG", "pathway_ids": ["R-HSA-6783310", "R-HSA-9833482", "R-MMU-9833482", "R-MMU-6783310"], "pathways": ["R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR039685": {"description": "Fanconi anemia group E protein", "go_ids": ["GO:0036297", "GO:0043240"], "go_terms": ["GO:0036297:interstrand cross-link repair:P", "GO:0043240:Fanconi anaemia nuclear complex:C"], "name": "FANCE", "pathway_ids": ["R-HSA-9833482", "R-HSA-6783310"], "pathways": ["R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR039687": {"description": "Nephrocystin-1", "go_ids": [], "go_terms": [], "name": "NPHP1", "pathway_ids": ["R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR039688": {"description": "STAC1/2/3", "go_ids": [], "go_terms": [], "name": "STAC1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039689": {"description": "B-cell differentiation antigen CD72", "go_ids": ["GO:0004888", "GO:0005886"], "go_terms": ["GO:0004888:transmembrane signaling receptor activity:F", "GO:0005886:plasma membrane:C"], "name": "CD72", "pathway_ids": ["R-MMU-416700", "R-HSA-416700"], "pathways": ["R-MMU-416700:r:Other semaphorin interactions", "R-HSA-416700:r:Other semaphorin interactions"], "type": "Family"}, "IPR039690": {"description": "U11/U12 small nuclear ribonucleoprotein 25kDa protein", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "SNRNP25", "pathway_ids": ["R-BTA-72165", "R-MMU-72165", "R-HSA-72165"], "pathways": ["R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway"], "type": "Family"}, "IPR039691": {"description": "Zinc finger CCCH domain-containing protein A/B", "go_ids": ["GO:0035198"], "go_terms": ["GO:0035198:miRNA binding:F"], "name": "ZC3H7A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039693": {"description": "Rtr1/RPAP2", "go_ids": ["GO:0008420", "GO:0043175"], "go_terms": ["GO:0008420:RNA polymerase II CTD heptapeptide repeat phosphatase activity:F", "GO:0043175:RNA polymerase core enzyme binding:F"], "name": "Rtr1/RPAP2", "pathway_ids": ["R-SCE-6807505", "R-CEL-6807505", "R-HSA-6807505", "R-RNO-6807505", "R-MMU-6807505", "R-DRE-6807505"], "pathways": ["R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR039694": {"description": "WD repeat-containing protein 11", "go_ids": [], "go_terms": [], "name": "WDR11", "pathway_ids": ["R-HSA-9013407", "R-MMU-9013407", "R-DRE-9013407"], "pathways": ["R-HSA-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-DRE-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR039697": {"description": "Iron-type alcohol dehydrogenase-like", "go_ids": [], "go_terms": [], "name": "Alcohol_dehydrogenase_Fe", "pathway_ids": ["R-CEL-880009", "R-DME-880009", "R-HSA-880009", "R-BTA-880009", "R-RNO-880009", "R-MMU-880009", "R-DDI-880009"], "pathways": ["R-CEL-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DME-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DDI-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "type": "Family"}, "IPR039698": {"description": "Polyprenal reductase", "go_ids": ["GO:0016627", "GO:0043048"], "go_terms": ["GO:0016627:oxidoreductase activity, acting on the CH-CH group of donors:F", "GO:0043048:dolichyl monophosphate biosynthetic process:P"], "name": "Dfg10/SRD5A3", "pathway_ids": ["PWY-6129", "R-DRE-193048", "R-DME-193048", "R-XTR-193048", "R-XTR-446199", "R-SCE-446199", "R-CEL-193048", "R-RNO-193048", "R-HSA-446199", "R-RNO-446199", "R-SPO-193048", "R-DME-446199", "R-CEL-446199", "R-HSA-4755579", "R-SPO-446199", "R-SCE-193048", "R-DRE-446199", "R-HSA-193048", "R-MMU-193048", "R-MMU-446199"], "pathways": ["PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "R-DRE-193048:r:Androgen biosynthesis", "R-DME-193048:r:Androgen biosynthesis", "R-XTR-193048:r:Androgen biosynthesis", "R-XTR-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-446199:r:Synthesis of dolichyl-phosphate", "R-CEL-193048:r:Androgen biosynthesis", "R-RNO-193048:r:Androgen biosynthesis", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-RNO-446199:r:Synthesis of dolichyl-phosphate", "R-SPO-193048:r:Androgen biosynthesis", "R-DME-446199:r:Synthesis of dolichyl-phosphate", "R-CEL-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-4755579:r:Defective SRD5A3 causes SRD5A3-CDG, KHRZ", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-193048:r:Androgen biosynthesis", "R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-193048:r:Androgen biosynthesis", "R-MMU-193048:r:Androgen biosynthesis", "R-MMU-446199:r:Synthesis of dolichyl-phosphate"], "type": "Family"}, "IPR039699": {"description": "Large ribosomal subunit protein uL30", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL30", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-GGA-72706", "R-CEL-9954716", "R-CEL-9954714", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-MMU-6791226", "R-HSA-1799339", "R-HSA-2408557", "R-BTA-156827", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-GGA-9954716", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-GGA-975956", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-RNO-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-GGA-9954714", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-GGA-9954709", "R-BTA-9954714", "R-GGA-975957", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-GGA-1799339", "R-DME-975957", "R-DDI-156827", "R-DDI-9954716", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-GGA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR039700": {"description": "Lymphocyte antigen 6G6e", "go_ids": [], "go_terms": [], "name": "Ly6g6e", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039701": {"description": "HCLS1-binding protein 3", "go_ids": [], "go_terms": [], "name": "HS1BP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039702": {"description": "Farnesyl pyrophosphate synthase-like", "go_ids": ["GO:0008299", "GO:0016765"], "go_terms": ["GO:0008299:isoprenoid biosynthetic process:P", "GO:0016765:transferase activity, transferring alkyl or aryl (other than methyl) groups:F"], "name": "FPS1-like", "pathway_ids": ["PWY-5122", "PWY-7102", "PWY-7709", "PWY-7410", "PWY-6859", "PWY-6383", "PWY-7182", "PWY-7721", "PWY-7659", "PWY-7141", "PWY-7736", "PWY-5123", "R-SCE-9969896", "R-DDI-9969896", "R-HSA-9969896", "R-MMU-9969896", "R-HSA-2426168", "R-RNO-9969896", "R-SPO-9969896"], "pathways": ["PWY-5122:t:geranyl diphosphate biosynthesis", "PWY-7102:t:bisabolene biosynthesis (engineered)", "PWY-7709:t:(3R)-linalool biosynthesis", "PWY-7410:t:ipsdienol biosynthesis", "PWY-6859:t:all-trans-farnesol biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-7182:t:linalool biosynthesis I", "PWY-7721:t:methyl phomopsenoate biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7141:t:(3S)-linalool biosynthesis", "PWY-7736:t:stellatic acid biosynthesis", "PWY-5123:t:trans, trans-farnesyl diphosphate biosynthesis", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Family"}, "IPR039703": {"description": "Protein N-terminal amidase", "go_ids": ["GO:0070773", "GO:0008418"], "go_terms": ["GO:0070773:protein-N-terminal glutamine amidohydrolase activity:F", "GO:0008418:protein-N-terminal asparagine amidohydrolase activity:F"], "name": "Nta1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039704": {"description": "Myogenic factor", "go_ids": ["GO:0007517", "GO:0006355"], "go_terms": ["GO:0007517:muscle organ development:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Myogenic_factor", "pathway_ids": ["R-HSA-9839394", "R-MMU-525793", "R-SSC-525793", "R-DME-525793", "R-GGA-525793", "R-HSA-525793", "R-RNO-525793", "R-BTA-525793"], "pathways": ["R-HSA-9839394:r:TGFBR3 expression", "R-MMU-525793:r:Myogenesis", "R-SSC-525793:r:Myogenesis", "R-DME-525793:r:Myogenesis", "R-GGA-525793:r:Myogenesis", "R-HSA-525793:r:Myogenesis", "R-RNO-525793:r:Myogenesis", "R-BTA-525793:r:Myogenesis"], "type": "Family"}, "IPR039706": {"description": "Major intrinsically disordered Notch2-binding receptor 1-like", "go_ids": [], "go_terms": [], "name": "MINAR1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039707": {"description": "Macrophage-expressed gene 1 protein", "go_ids": [], "go_terms": [], "name": "MPEG1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039708": {"description": "Probable membrane protein MT1774/Rv1733c-like", "go_ids": [], "go_terms": [], "name": "MT1774/Rv1733c-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039709": {"description": "Putative antitoxin VapB3-like", "go_ids": [], "go_terms": [], "name": "VapB3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039711": {"description": "Protein GDF5OS, mitochondrial", "go_ids": [], "go_terms": [], "name": "GDF5OS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039712": {"description": "Meiotic expression up-regulated protein 6", "go_ids": [], "go_terms": [], "name": "Meu6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039713": {"description": "At2g23090-like", "go_ids": [], "go_terms": [], "name": "At2g23090-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039714": {"description": "Transmembrane protein 134", "go_ids": [], "go_terms": [], "name": "TMEM134", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039715": {"description": "Zinc finger CCHC domain-containing protein 10", "go_ids": [], "go_terms": [], "name": "ZCCHC10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039717": {"description": "Protein Hgh1", "go_ids": [], "go_terms": [], "name": "Hgh1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039718": {"description": "Ribonucleoside-diphosphate reductase large subunit", "go_ids": [], "go_terms": [], "name": "Rrm1", "pathway_ids": ["PWY-7198", "PWY-6545", "PWY-7226", "PWY-7222", "PWY-7184", "PWY-7220", "PWY-7227", "PWY-7210", "R-HSA-5213460", "R-HSA-9610379", "R-DRE-499943", "R-DME-499943", "R-CEL-499943", "R-HSA-9609690", "R-HSA-9686347", "R-HSA-499943", "R-MMU-499943"], "pathways": ["PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7226:t:guanosine deoxyribonucleotides de novo biosynthesis I", "PWY-7222:t:guanosine deoxyribonucleotides de novo biosynthesis II", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7220:t:adenosine deoxyribonucleotides de novo biosynthesis II", "PWY-7227:t:adenosine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-9610379:r:HCMV Late Events", "R-DRE-499943:r:Interconversion of nucleotide di- and triphosphates", "R-DME-499943:r:Interconversion of nucleotide di- and triphosphates", "R-CEL-499943:r:Interconversion of nucleotide di- and triphosphates", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR039719": {"description": "F-box only protein 28", "go_ids": [], "go_terms": [], "name": "FBXO28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039720": {"description": "Transmembrane protein 94", "go_ids": [], "go_terms": [], "name": "TMEM94", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039721": {"description": "D-glucuronyl C5-epimerase", "go_ids": ["GO:0015012", "GO:0047464"], "go_terms": ["GO:0015012:heparan sulfate proteoglycan biosynthetic process:P", "GO:0047464:heparosan-N-sulfate-glucuronate 5-epimerase activity:F"], "name": "C5-epimerase", "pathway_ids": ["PWY-6558", "R-HSA-2022928"], "pathways": ["PWY-6558:t:heparan sulfate biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis"], "type": "Family"}, "IPR039722": {"description": "Nonsense-mediated mRNA decay protein 3", "go_ids": ["GO:0000184"], "go_terms": ["GO:0000184:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay:P"], "name": "Upf3", "pathway_ids": ["R-DRE-159236", "R-DRE-72163", "R-HSA-72163", "R-HSA-975957", "R-DRE-73856", "R-SCE-975957", "R-SPO-159236", "R-HSA-9010553", "R-HSA-73856", "R-HSA-159236", "R-DRE-975957", "R-SPO-975957", "R-HSA-72187", "R-SPO-72163"], "pathways": ["R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039723": {"description": "Vps71/ZNHIT1", "go_ids": ["GO:0006338"], "go_terms": ["GO:0006338:chromatin remodeling:P"], "name": "Vps71/ZNHIT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039724": {"description": "WD repeat-containing protein 91", "go_ids": ["GO:0045022", "GO:0141039", "GO:0051898"], "go_terms": ["GO:0045022:early endosome to late endosome transport:P", "GO:0141039:phosphatidylinositol 3-kinase inhibitor activity:F", "GO:0051898:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction:P"], "name": "WDR91", "pathway_ids": ["R-DRE-9013148", "R-HSA-9013148"], "pathways": ["R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle"], "type": "Family"}, "IPR039725": {"description": "Coiled-coil and C2 domain-containing protein 1", "go_ids": ["GO:0001227"], "go_terms": ["GO:0001227:DNA-binding transcription repressor activity, RNA polymerase II-specific:F"], "name": "CC2D1A/B", "pathway_ids": ["R-DME-9668328", "R-CEL-9668328", "R-HSA-9668328", "R-MMU-9668328", "R-RNO-9668328"], "pathways": ["R-DME-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-CEL-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III"], "type": "Family"}, "IPR039726": {"description": "Pre-mRNA-processing factor Prp40", "go_ids": ["GO:0045292"], "go_terms": ["GO:0045292:mRNA cis splicing, via spliceosome:P"], "name": "Prp40-like", "pathway_ids": ["R-SPO-9770562", "R-HSA-72163", "R-MMU-9770562", "R-HSA-9770562", "R-CEL-9770562", "R-MMU-72163"], "pathways": ["R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039727": {"description": "SERRATE/Ars2", "go_ids": [], "go_terms": [], "name": "SE/Ars2", "pathway_ids": ["R-MMU-9930044", "R-CEL-6807505", "R-HSA-9930044", "R-HSA-6807505", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-DME-72163", "R-SPO-9930044", "R-DME-9930044", "R-MMU-6807505", "R-DRE-6807505", "R-BTA-9930044", "R-DRE-9930044", "R-DRE-72163", "R-SPO-9770562", "R-HSA-72163", "R-DME-9770562", "R-DME-6807505", "R-DRE-9770562", "R-CEL-9770562", "R-BTA-9770562", "R-CEL-9930044", "R-CEL-72163", "R-BTA-6807505", "R-SPO-72163", "R-HSA-9918481", "R-BTA-72163"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9930044:r:Nuclear RNA decay", "R-DME-9930044:r:Nuclear RNA decay", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-9930044:r:Nuclear RNA decay", "R-DRE-9930044:r:Nuclear RNA decay", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039728": {"description": "Golgi apparatus protein 1", "go_ids": [], "go_terms": [], "name": "GLG1", "pathway_ids": ["R-CEL-202733", "R-RNO-202733", "R-MMU-202733", "R-HSA-202733"], "pathways": ["R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR039729": {"description": "DNA fragmentation factor 40", "go_ids": ["GO:0006309", "GO:0004520"], "go_terms": ["GO:0006309:apoptotic DNA fragmentation:P", "GO:0004520:DNA endonuclease activity:F"], "name": "DFF40", "pathway_ids": ["R-HSA-140342", "R-MMU-140342", "R-RNO-140342"], "pathways": ["R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-140342:r:Apoptosis induced DNA fragmentation"], "type": "Family"}, "IPR039730": {"description": "Jlp2/Ccd25", "go_ids": [], "go_terms": [], "name": "Jlp2/Ccd25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039731": {"description": "CAAX prenyl protease 2, eukaryotes", "go_ids": ["GO:0071586", "GO:0004222", "GO:0005789"], "go_terms": ["GO:0071586:CAAX-box protein processing:P", "GO:0004222:metalloendopeptidase activity:F", "GO:0005789:endoplasmic reticulum membrane:C"], "name": "Rce1", "pathway_ids": ["R-CEL-5689880", "R-MMU-5689880", "R-RNO-5689880", "R-BTA-5689880", "R-MMU-9648002", "R-HSA-5689880", "R-BTA-9648002", "R-RNO-9648002", "R-HSA-9648002", "R-DME-5689880", "R-CEL-9648002", "R-DME-9648002"], "pathways": ["R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-5689880:r:Ub-specific processing proteases", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9648002:r:RAS processing", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-9648002:r:RAS processing", "R-RNO-9648002:r:RAS processing", "R-HSA-9648002:r:RAS processing", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-9648002:r:RAS processing", "R-DME-9648002:r:RAS processing"], "type": "Family"}, "IPR039732": {"description": "Ubiquitin-like modifier Hub1/Ubl5", "go_ids": ["GO:0036211"], "go_terms": ["GO:0036211:protein modification process:P"], "name": "Hub1/Ubl5", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-CEL-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039733": {"description": "Protein N-terminal glutamine amidohydrolase", "go_ids": ["GO:0070773", "GO:0008418"], "go_terms": ["GO:0070773:protein-N-terminal glutamine amidohydrolase activity:F", "GO:0008418:protein-N-terminal asparagine amidohydrolase activity:F"], "name": "NTAQ1", "pathway_ids": ["PWY-7799"], "pathways": ["PWY-7799:t:Arg/N-end rule pathway (eukaryotic)"], "type": "Family"}, "IPR039735": {"description": "Cysteine-rich hydrophobic domain-containing protein 1/2", "go_ids": [], "go_terms": [], "name": "CHIC1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039736": {"description": "RNA-directed RNA polymerase L, C-terminal", "go_ids": [], "go_terms": [], "name": "L_poly_C", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-9828721", "R-HSA-9833110", "R-HSA-9828806", "R-HSA-9820962", "R-HSA-9828642", "R-HSA-9834752", "R-HSA-9820960"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-9828721:r:Translation of respiratory syncytial virus mRNAs", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-9820962:r:Assembly and release of respiratory syncytial virus (RSV) virions", "R-HSA-9828642:r:Respiratory syncytial virus genome transcription", "R-HSA-9834752:r:Respiratory syncytial virus genome replication", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry"], "type": "Domain"}, "IPR039737": {"description": "Type I inositol 1,4,5-trisphosphate 5-phosphatase", "go_ids": ["GO:0004445"], "go_terms": ["GO:0004445:inositol-polyphosphate 5-phosphatase activity:F"], "name": "INPP5A", "pathway_ids": ["PWY-6363", "PWY-6362", "PWY-6364", "R-HSA-1855183", "R-CEL-1855183", "R-MMU-1855183", "R-RNO-1855183"], "pathways": ["PWY-6363:t:D-myo-inositol (1,4,5)-trisphosphate degradation", "PWY-6362:t:1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)", "PWY-6364:t:D-myo-inositol (1,3,4)-trisphosphate biosynthesis", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-CEL-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol"], "type": "Family"}, "IPR039739": {"description": "RING-finger protein MAG2/RNF10", "go_ids": [], "go_terms": [], "name": "MAG2/RNF10", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR039740": {"description": "CCR4-NOT transcription complex subunit 10", "go_ids": ["GO:0030014"], "go_terms": ["GO:0030014:CCR4-NOT complex:C"], "name": "CNOT10", "pathway_ids": ["R-HSA-6804115", "R-MMU-429947", "R-BTA-429947", "R-HSA-429947", "R-HSA-9820841", "R-MMU-6804115", "R-GGA-6804115", "R-DRE-6804115", "R-BTA-6804115", "R-GGA-429947", "R-RNO-6804115"], "pathways": ["R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-BTA-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-GGA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-GGA-429947:r:Deadenylation of mRNA", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Family"}, "IPR039741": {"description": "UDP-sugar pyrophosphorylase", "go_ids": [], "go_terms": [], "name": "UDP-sugar_pyrophosphorylase", "pathway_ids": ["R-SCE-446210", "R-SPO-446210", "R-CEL-446210", "R-MMU-446210", "R-DDI-446210", "R-HSA-446210"], "pathways": ["R-SCE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SPO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-CEL-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-DDI-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine"], "type": "Family"}, "IPR039742": {"description": "Protein Shq1", "go_ids": ["GO:0000493"], "go_terms": ["GO:0000493:box H/ACA snoRNP assembly:P"], "name": "Shq1", "pathway_ids": ["R-BTA-171319", "R-HSA-171319", "R-CEL-171319", "R-DRE-171319", "R-SPO-171319", "R-DME-171319", "R-SCE-171319", "R-MMU-171319"], "pathways": ["R-BTA-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-CEL-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-DME-171319:r:Telomere Extension By Telomerase", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Family"}, "IPR039743": {"description": "Endo-beta-1,6-galactanase/Exo-beta-1,6-galactobiohydrolase", "go_ids": ["GO:0004553"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "6GAL/EXGAL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039744": {"description": "Small ribosomal subunit protein uS14, eukaryotes/archaea", "go_ids": ["GO:0003735", "GO:0008270"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0008270:zinc ion binding:F"], "name": "RIbosomal_uS14_euk_arc", "pathway_ids": ["R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-HSA-72695", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-DME-72706", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-BTA-72695", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-DDI-72695", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-RNO-72649", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-SPO-72689", "R-DDI-72702", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", "R-MMU-72689", "R-SCE-72706", "R-DDI-6791226", "R-DME-72649", "R-HSA-156827", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DME-1799339", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-SCE-156827", "R-MMU-72702", "R-DME-72695", "R-DME-975956", "R-BTA-9954716", "R-DME-975957", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-HSA-9754678", "R-SCE-9954714", "R-HSA-72649", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-SCE-72649", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72649:r:Translation initiation complex formation", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-72649:r:Translation 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Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER"], "type": "Family"}, "IPR039748": {"description": "DNA-directed RNA polymerase III subunit RPC3", "go_ids": ["GO:0005666", "GO:0003697"], "go_terms": ["GO:0005666:RNA polymerase III complex:C", "GO:0003697:single-stranded DNA binding:F"], "name": "RPC3", "pathway_ids": ["R-SCE-76066", "R-DDI-76066", "R-HSA-76071", "R-RNO-76071", "R-HSA-76066", "R-HSA-73980", "R-SPO-76066", "R-SPO-76061", "R-MMU-76071", "R-BTA-76071", "R-MMU-76066", "R-RNO-76066", "R-DRE-76071", "R-BTA-76066", "R-BTA-76061", "R-DRE-76066", "R-DDI-76061", "R-RNO-76061", "R-HSA-76061", "R-HSA-1834949", "R-MMU-76061", "R-HSA-73780", "R-HSA-749476", "R-DRE-76061", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DRE-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DRE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-DRE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR039749": {"description": "NEDD8 ultimate buster 1", "go_ids": [], "go_terms": [], "name": "NUB1", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation"], "type": "Family"}, "IPR039750": {"description": "Dynein regulatory complex protein", "go_ids": ["GO:0070286", "GO:0005858"], "go_terms": ["GO:0070286:axonemal dynein complex assembly:P", "GO:0005858:axonemal dynein complex:C"], "name": "DRC1/DRC2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039751": {"description": "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 /2", "go_ids": [], "go_terms": [], "name": "HERPUD1/2", "pathway_ids": ["R-SPO-8856825", "R-HSA-380994"], "pathways": ["R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress"], "type": "Family"}, "IPR039752": {"description": "F-box only protein", "go_ids": [], "go_terms": [], "name": "F-box_only", "pathway_ids": ["R-BTA-983168", "R-MMU-8951664", "R-BTA-8951664", "R-HSA-390471", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR039753": {"description": "mRNA cap guanine-N7 methyltransferase", "go_ids": ["GO:0004482"], "go_terms": ["GO:0004482:mRNA 5'-cap (guanine-N7-)-methyltransferase activity:F"], "name": "RG7MT1", "pathway_ids": ["PWY-7375", "R-RNO-72086", "R-SPO-77075", "R-XTR-77075", "R-SCE-72086", "R-DRE-72086", "R-CEL-72086", "R-HSA-72086", "R-DME-77075", "R-CEL-77075", "R-DRE-77075", "R-RNO-77075", "R-DME-72086", "R-MMU-77075", "R-SCE-77075", "R-HSA-167160", "R-HSA-77075", "R-MMU-72086", "R-SPO-72086", "R-XTR-72086"], "pathways": ["PWY-7375:t:mRNA capping I", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-XTR-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-72086:r:mRNA Capping", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-72086:r:mRNA Capping", "R-SPO-72086:r:mRNA Capping", "R-XTR-72086:r:mRNA Capping"], "type": "Family"}, "IPR039754": {"description": "Pre-rRNA-processing protein Esf1", "go_ids": ["GO:0006364"], "go_terms": ["GO:0006364:rRNA processing:P"], "name": "Esf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039755": {"description": "TBC1 domain family member 23", "go_ids": ["GO:0042147"], "go_terms": ["GO:0042147:retrograde transport, endosome to Golgi:P"], "name": "TBC1D23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039756": {"description": "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2", "go_ids": ["GO:0004430"], "go_terms": ["GO:0004430:1-phosphatidylinositol 4-kinase activity:F"], "name": "Lsb6/PI4K2", "pathway_ids": ["PWY-6351", "PWY-6352", "R-SCE-1660516", "R-HSA-1483248", "R-MMU-1660516", "R-SCE-1660514", "R-SPO-1660514", "R-SCE-1660499", "R-SPO-1660499", "R-HSA-1660514", "R-RNO-1660514", "R-MMU-1483248", "R-HSA-1660499", "R-DRE-1660514", "R-MMU-1660499", "R-XTR-1483248", "R-HSA-1660516", "R-SPO-1660516", "R-XTR-1660499", "R-XTR-1660514", "R-RNO-1660499", "R-SCE-1483248", "R-RNO-1660516", "R-RNO-1483248", "R-XTR-1660516", "R-DRE-1483248", "R-MMU-1660514", "R-SPO-1483248", "R-DRE-1660516", "R-DRE-1660499"], "pathways": ["PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-DRE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-XTR-1483248:r:Synthesis of PIPs at the ER membrane", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-XTR-1660499:r:Synthesis of PIPs at the plasma membrane", "R-XTR-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SCE-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-1483248:r:Synthesis of PIPs at the ER membrane", "R-XTR-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DRE-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-DRE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Family"}, "IPR039757": {"description": "Eukaryotic translation initiation factor 2D", "go_ids": ["GO:0003743", "GO:0001731"], "go_terms": ["GO:0003743:translation initiation factor activity:F", "GO:0001731:formation of translation preinitiation complex:P"], "name": "EIF2D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039758": {"description": "N-acetyl-D-glucosamine kinase NAGK-like", "go_ids": ["GO:0045127"], "go_terms": ["GO:0045127:N-acetylglucosamine kinase activity:F"], "name": "NAGK-like", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-6517", "PWY-7321", "PWY-6138", "PWY-8393", "PWY-8367", "PWY-6906", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402", "R-MMU-446210", "R-RNO-446210", "R-HSA-446210"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-6517:t:N-acetylglucosamine degradation II", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-6138:t:CMP-N-acetylneuraminate biosynthesis I (eukaryotes)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6906:t:chitin derivatives degradation", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-RNO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine"], "type": "Family"}, "IPR039760": {"description": "MOFRL domain-containing protein", "go_ids": ["GO:0008887"], "go_terms": ["GO:0008887:glycerate kinase activity:F"], "name": "MOFRL_protein", "pathway_ids": ["R-HSA-70350", "R-BTA-70350", "R-RNO-70350", "R-DME-70350", "R-DRE-70350", "R-CEL-70350", "R-MMU-70350"], "pathways": ["R-HSA-70350:r:Fructose catabolism", "R-BTA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-DME-70350:r:Fructose catabolism", "R-DRE-70350:r:Fructose catabolism", "R-CEL-70350:r:Fructose catabolism", "R-MMU-70350:r:Fructose catabolism"], "type": "Family"}, "IPR039761": {"description": "Ribosome biogenesis protein Bms1/Tsr1", "go_ids": ["GO:0042254"], "go_terms": ["GO:0042254:ribosome biogenesis:P"], "name": "Bms1/Tsr1", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR039762": {"description": "Nonsense-mediated mRNA decay protein Nmd2/UPF2", "go_ids": ["GO:0000184"], "go_terms": ["GO:0000184:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay:P"], "name": "Nmd2/UPF2", "pathway_ids": ["R-HSA-975957", "R-SPO-975957", "R-SCE-975957", "R-HSA-9010553", "R-MMU-975957"], "pathways": ["R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Family"}, "IPR039763": {"description": "Damage-control phosphatase ARMT1", "go_ids": [], "go_terms": [], "name": "ARMT1", "pathway_ids": ["PWY-6686", "PWY-7045", "PWY-6575", "PWY-7161", "PWY-7751", "PWY-8430", "PWY-8426", "PWY-6627", "PWY-7881", "PWY-8238", "PWY-7689", "PWY-7743", "PWY-7100", "PWY-7321", "PWY-8052", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-6365", "PWY-8381", "PWY-7517", "PWY-7717", "PWY-7440", "PWY-6352", "PWY-6991", "PWY-8437", "PWY-7878", "PWY-6310", "PWY-7692", "PWY-7119", "PWY-7498", "PWY-6990", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-6720", "PWY-8282", "PWY-7135", "PWY-7485", "PWY-8429", "PWY-7659", "PWY-7667", "PWY-7150", "PWY-7771", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8176", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-8372", "PWY-6736", "PWY-8368", "PWY-7531", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-6724", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-6581", "PWY-4202", "PWY-7186", "PWY-7882", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-8373", "PWY-6795", "PWY-4702", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6368", "PWY-6955", "PWY-8257", "PWY-7483", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-7826", "PWY-6477", "PWY-6456", "PWY-6664", "PWY-7298", "PWY-6366", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7863", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7018", "PWY-8247", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-5491", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-7045:t:mithramycin biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7771:t:butachlor degradation", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-6724:t:starch degradation II", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-4702:t:phytate degradation I", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-6456:t:serinol biosynthesis", "PWY-6664:t:di-myo-inositol phosphate biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR039764": {"description": "RNA binding protein HABP4/SERBP1-like", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "HABP4/SERBP1-like", "pathway_ids": ["R-HSA-114608", "R-DRE-114608", "R-DDI-114608", "R-SPO-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-DDI-114608:r:Platelet degranulation", "R-SPO-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR039765": {"description": "Protein Yip5/YIPF1/YIPF2", "go_ids": ["GO:0031267", "GO:0005794", "GO:0016192"], "go_terms": ["GO:0031267:small GTPase binding:F", "GO:0005794:Golgi apparatus:C", "GO:0016192:vesicle-mediated transport:P"], "name": "Yip5/YIPF1/YIPF2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039766": {"description": "Vacuolar protein sorting-associated protein 53", "go_ids": ["GO:0000938", "GO:0042147"], "go_terms": ["GO:0000938:GARP complex:C", "GO:0042147:retrograde transport, endosome to Golgi:P"], "name": "Vps53", "pathway_ids": ["R-HSA-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR039767": {"description": "RalA-binding protein 1", "go_ids": ["GO:0005096", "GO:0031267", "GO:0007264"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0031267:small GTPase binding:F", "GO:0007264:small GTPase-mediated signal transduction:P"], "name": "RALBP1", "pathway_ids": ["PWY-8259", "PWY-8301", "PWY-4061", "PWY-6842", "PWY-4621", "PWY-6972", "R-HSA-9013149", "R-RNO-9013149", "R-DME-9013149", "R-RNO-9013148", "R-MMU-9013148", "R-MMU-9013149", "R-DME-9013148", "R-HSA-9013148"], "pathways": ["PWY-8259:t:arsenic detoxification (plants)", "PWY-8301:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis", "PWY-4061:t:glutathione-mediated detoxification I", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-4621:t:arsenic detoxification (bacteria)", "PWY-6972:t:oleandomycin activation/inactivation", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle"], "type": "Family"}, "IPR039768": {"description": "Ribosomal export protein Nmd3", "go_ids": ["GO:0043023"], "go_terms": ["GO:0043023:ribosomal large subunit binding:F"], "name": "Nmd3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039769": {"description": "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like", "go_ids": ["GO:0016435", "GO:0070476"], "go_terms": ["GO:0016435:rRNA (guanine) methyltransferase activity:F", "GO:0070476:rRNA (guanine-N7)-methylation:P"], "name": "Bud23-like", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR039770": {"description": "Ribosome biogenesis protein Rpf2", "go_ids": ["GO:0000470", "GO:0000027", "GO:0019843"], "go_terms": ["GO:0000470:maturation of LSU-rRNA:P", "GO:0000027:ribosomal large subunit assembly:P", "GO:0019843:rRNA binding:F"], "name": "Rpf2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039771": {"description": "Exosome complex component Csl4", "go_ids": ["GO:0006396", "GO:0000178"], "go_terms": ["GO:0006396:RNA processing:P", "GO:0000178:exosome (RNase complex):C"], "name": "Csl4", "pathway_ids": ["R-MMU-9930044", "R-MMU-450385", "R-MMU-6791226", "R-HSA-9930044", "R-CEL-450385", "R-SCE-450513", "R-MMU-429958", "R-SPO-9930044", "R-CEL-450513", "R-SCE-450385", "R-HSA-450385", "R-SCE-429958", "R-HSA-380994", "R-MMU-450513", "R-SCE-6791226", "R-CEL-429958", "R-MMU-450604", "R-HSA-6791226", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-CEL-6791226", "R-HSA-429958", "R-SPO-429958", "R-SPO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR039772": {"description": "RNA methyltransferase Bin3-like", "go_ids": [], "go_terms": [], "name": "Bin3-like", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-203927"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Family"}, "IPR039773": {"description": "Molecular chaperone regulator BAG", "go_ids": ["GO:0051087"], "go_terms": ["GO:0051087:protein-folding chaperone binding:F"], "name": "BAG_chaperone_regulator", "pathway_ids": ["R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-MMU-75893", "R-HSA-75893", "R-HSA-5655302", "R-HSA-8853336", "R-MMU-3371453"], "pathways": ["R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-75893:r:TNF signaling", "R-HSA-75893:r:TNF signaling", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Family"}, "IPR039774": {"description": "Transcriptional regulatory protein Sin3-like", "go_ids": ["GO:0003714"], "go_terms": ["GO:0003714:transcription corepressor activity:F"], "name": "Sin3-like", "pathway_ids": ["R-HSA-9022702", "R-MMU-8936459", "R-MMU-9824594", "R-HSA-9824594", "R-HSA-9022692", "R-MMU-3899300", "R-HSA-8936459", "R-HSA-427413", "R-HSA-983231", "R-CEL-9825892", "R-HSA-9022538", "R-CEL-9824594", "R-HSA-9615017", "R-MMU-9022692", "R-HSA-9707564", "R-HSA-400206", "R-HSA-9022699", "R-HSA-3899300", "R-MMU-9825892", "R-HSA-9825892", "R-HSA-9701898", "R-MMU-400206", "R-MMU-9707564"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9022538:r:Loss of MECP2 binding ability to 5mC-DNA", "R-CEL-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR039775": {"description": "Homeodomain containing protein PHTF1/2", "go_ids": ["GO:0005783"], "go_terms": ["GO:0005783:endoplasmic reticulum:C"], "name": "PHTF1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039776": {"description": "Sister chromatid cohesion protein Pds5", "go_ids": ["GO:0007064"], "go_terms": ["GO:0007064:mitotic sister chromatid cohesion:P"], "name": "Pds5", "pathway_ids": ["R-HSA-2468052", "R-DRE-2468052", "R-SCE-2468052", "R-MMU-2500257", "R-SPO-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-SPO-2470946", "R-RNO-2500257", "R-DRE-2500257", "R-MMU-2467813", "R-HSA-2470946", "R-RNO-2470946", "R-DRE-2470946", "R-DRE-2467813", "R-SCE-2500257", "R-DDI-2500257", "R-DDI-2468052", "R-RNO-2468052", "R-RNO-2467813", "R-MMU-2468052", "R-MMU-2470946", "R-DDI-2470946"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-DRE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-RNO-2470946:r:Cohesin Loading onto Chromatin", "R-DRE-2470946:r:Cohesin Loading onto Chromatin", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-2468052:r:Establishment of Sister Chromatid Cohesion", "R-RNO-2468052:r:Establishment of Sister Chromatid Cohesion", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-DDI-2470946:r:Cohesin Loading onto Chromatin"], "type": "Family"}, "IPR039777": {"description": "Interferon-related developmental regulator", "go_ids": [], "go_terms": [], "name": "IFRD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039778": {"description": "Programmed cell death protein 4", "go_ids": ["GO:0045892"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "PDCD4", "pathway_ids": ["R-HSA-8950505"], "pathways": ["R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "type": "Family"}, "IPR039779": {"description": "RFX-like DNA-binding protein", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "RFX-like", "pathway_ids": ["R-HSA-210745"], "pathways": ["R-HSA-210745:r:Regulation of gene expression in beta cells"], "type": "Family"}, "IPR039780": {"description": "CCR4-NOT transcription complex subunit 4", "go_ids": ["GO:0004842", "GO:0030014"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F", "GO:0030014:CCR4-NOT complex:C"], "name": "Mot2", "pathway_ids": ["PWY-7511", "R-MMU-6804115", "R-HSA-6804115", "R-MMU-429947", "R-HSA-429947", "R-HSA-9820841"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Family"}, "IPR039781": {"description": "Rad21/Rec8-like protein", "go_ids": ["GO:0007062", "GO:0008278"], "go_terms": ["GO:0007062:sister chromatid cohesion:P", "GO:0008278:cohesin complex:C"], "name": "Rad21/Rec8-like", "pathway_ids": ["R-HSA-2468052", "R-SCE-3108214", "R-SPO-2500257", "R-SCE-2468052", "R-MMU-2500257", "R-SPO-3108214", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-3108214", "R-SPO-2470946", "R-BTA-2468052", "R-MMU-2467813", "R-HSA-2470946", "R-HSA-1221632", "R-SCE-2500257", "R-BTA-3108214", "R-BTA-2467813", "R-BTA-2500257", "R-MMU-2470946", "R-MMU-3108214", "R-MMU-2468052", "R-HSA-9018519", "R-BTA-2470946"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-BTA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-1221632:r:Meiotic synapsis", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-BTA-2470946:r:Cohesin Loading onto Chromatin"], "type": "Family"}, "IPR039782": {"description": "Intermembrane lipid transfer protein VPS13B", "go_ids": [], "go_terms": [], "name": "VPS13B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039785": {"description": "Deubiquitinating enzyme MINDY-3/4", "go_ids": ["GO:1990380", "GO:0004843", "GO:0071108"], "go_terms": ["GO:1990380:K48-linked deubiquitinase activity:F", "GO:0004843:cysteine-type deubiquitinase activity:F", "GO:0071108:protein K48-linked deubiquitination:P"], "name": "MINY3/4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039786": {"description": "Protein EFR3", "go_ids": [], "go_terms": [], "name": "EFR3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039787": {"description": "Poly(U)-specific endoribonuclease", "go_ids": ["GO:0004521"], "go_terms": ["GO:0004521:RNA endonuclease activity:F"], "name": "ENDOU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039788": {"description": "Nucleolar protein 4 family", "go_ids": [], "go_terms": [], "name": "NOL4/NOL4L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039789": {"description": "CYFIP-related Rac1 interactor", "go_ids": ["GO:0030833", "GO:0031267"], "go_terms": ["GO:0030833:regulation of actin filament polymerization:P", "GO:0031267:small GTPase binding:F"], "name": "CYRI", "pathway_ids": ["R-DDI-114608", "R-HSA-114608", "R-BTA-114608", "R-MMU-114608"], "pathways": ["R-DDI-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR039790": {"description": "Cysteine and histidine-rich domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "CHRD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039791": {"description": "Chorion-specific transcription factor GCM", "go_ids": ["GO:0001228", "GO:0006355"], "go_terms": ["GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "GCM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039793": {"description": "Uroporphyrinogen-III synthase-like", "go_ids": ["GO:0004852", "GO:0006780"], "go_terms": ["GO:0004852:uroporphyrinogen-III synthase activity:F", "GO:0006780:uroporphyrinogen III biosynthetic process:P"], "name": "UROS/Hem4", "pathway_ids": ["PWY-5188", "PWY-5189"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "PWY-5189:t:tetrapyrrole biosynthesis II (from glycine)"], "type": "Family"}, "IPR039794": {"description": "Glucosidase II beta subunit-like", "go_ids": [], "go_terms": [], "name": "Gtb1-like", "pathway_ids": ["R-BTA-8957275", "R-HSA-532668", "R-HSA-9683686", "R-HSA-879415", "R-MMU-381426", "R-HSA-9694548", "R-MMU-9768727", "R-BTA-381426", "R-BTA-9768727", "R-HSA-8957275", "R-HSA-9768727", "R-HSA-901042", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9694548:r:Maturation of spike protein", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR039795": {"description": "E3 ubiquitin-protein ligase listerin", "go_ids": ["GO:1990112", "GO:0061630", "GO:1990116"], "go_terms": ["GO:1990112:RQC complex:C", "GO:0061630:ubiquitin protein ligase activity:F", "GO:1990116:ribosome-associated ubiquitin-dependent protein catabolic process:P"], "name": "LTN1/Rkr1", "pathway_ids": ["PWY-7511", "R-SPO-9954709", "R-DDI-983168", "R-DME-983168", "R-DME-9954709", "R-CEL-9954709", "R-HSA-9954709", "R-MMU-983168", "R-SPO-983168", "R-DDI-9954709", "R-MMU-9954709", "R-SCE-9954709", "R-HSA-983168", "R-SCE-983168", "R-CEL-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR039796": {"description": "MIP18 family", "go_ids": ["GO:0051604"], "go_terms": ["GO:0051604:protein maturation:P"], "name": "MIP18", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Family"}, "IPR039797": {"description": "Protein Pecanex", "go_ids": [], "go_terms": [], "name": "Pecanex", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039798": {"description": "Sulfhydryl oxidase", "go_ids": ["GO:0016971"], "go_terms": ["GO:0016971:flavin-dependent sulfhydryl oxidase activity:F"], "name": "Sulfhydryl_oxidase", "pathway_ids": ["PWY-7533", "R-RNO-381426", "R-HSA-6798695", "R-HSA-114608", "R-RNO-8957275", "R-MMU-381426", "R-MMU-6798695", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR039799": {"description": "Sulfhydryl oxidase ALR/ERV", "go_ids": ["GO:0016971"], "go_terms": ["GO:0016971:flavin-dependent sulfhydryl oxidase activity:F"], "name": "ALR/ERV", "pathway_ids": ["PWY-7533", "R-HSA-1268020"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis", "R-HSA-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR039800": {"description": "Calcium uptake protein 1/2/3", "go_ids": ["GO:0006851", "GO:0005509"], "go_terms": ["GO:0006851:mitochondrial calcium ion transmembrane transport:P", "GO:0005509:calcium ion binding:F"], "name": "MICU1/2/3", "pathway_ids": ["R-DME-8949215", "R-BTA-8949664", "R-MMU-8949215", "R-MMU-8949664", "R-DRE-8949215", "R-HSA-8949215", "R-DME-8949664", "R-CEL-8949664", "R-HSA-8949664", "R-RNO-8949215", "R-HSA-9837999", "R-RNO-8949664", "R-XTR-8949215", "R-CEL-8949215", "R-BTA-8949215"], "pathways": ["R-DME-8949215:r:Mitochondrial calcium ion transport", "R-BTA-8949664:r:Processing of SMDT1", "R-MMU-8949215:r:Mitochondrial calcium ion transport", "R-MMU-8949664:r:Processing of SMDT1", "R-DRE-8949215:r:Mitochondrial calcium ion transport", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-DME-8949664:r:Processing of SMDT1", "R-CEL-8949664:r:Processing of SMDT1", "R-HSA-8949664:r:Processing of SMDT1", "R-RNO-8949215:r:Mitochondrial calcium ion transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-8949664:r:Processing of SMDT1", "R-XTR-8949215:r:Mitochondrial calcium ion transport", "R-CEL-8949215:r:Mitochondrial calcium ion transport", "R-BTA-8949215:r:Mitochondrial calcium ion transport"], "type": "Family"}, "IPR039801": {"description": "Epidermal growth factor receptor kinase substrate 8-like", "go_ids": [], "go_terms": [], "name": "EPS8-like", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Family"}, "IPR039802": {"description": "Myotubularin-related protein 14", "go_ids": ["GO:0004438"], "go_terms": ["GO:0004438:phosphatidylinositol-3-phosphate phosphatase activity:F"], "name": "MTMR14", "pathway_ids": ["R-HSA-1660499", "R-MMU-1660499", "R-HSA-1632852", "R-MMU-1632852"], "pathways": ["R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy"], "type": "Family"}, "IPR039808": {"description": "Cadherin", "go_ids": ["GO:0098609"], "go_terms": ["GO:0098609:cell-cell adhesion:P"], "name": "Cadherin", "pathway_ids": ["R-DRE-9768727", "R-RNO-1474228", "R-HSA-9766229", "R-HSA-351906", "R-HSA-9927418", "R-MMU-8957275", "R-RNO-525793", "R-HSA-9764562", "R-HSA-418990", "R-HSA-9764561", "R-DRE-5626467", "R-HSA-5218920", "R-DRE-6798695", "R-HSA-9823730", "R-MMU-381426", "R-GGA-8957275", "R-HSA-9926550", "R-CFA-418990", "R-HSA-9759811", "R-DRE-418990", "R-RNO-9768727", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-BTA-418990", "R-SSC-418990", "R-DRE-5218920", "R-CFA-351906", "R-DRE-6805567", "R-DRE-9764561", "R-MMU-351906", "R-GGA-525793", "R-DME-6809371", "R-MMU-9762292", "R-RNO-381426", "R-DRE-9766229", "R-CFA-1474228", "R-DRE-381426", "R-MMU-216083", "R-HSA-9762292", "R-HSA-198933", "R-DRE-351906", "R-HSA-9768727", "R-MMU-9768727", "R-MMU-9766229", "R-RNO-216083", "R-HSA-5626467", "R-DRE-1474228", "R-RNO-418990", "R-RNO-351906", "R-CFA-216083", "R-CFA-9768727", "R-MMU-9764561", "R-RNO-8957275", "R-SSC-5218920", "R-HSA-9938206", "R-GGA-381426", "R-HSA-525793", "R-DRE-8957275", "R-CFA-9766229", "R-RNO-9764561", "R-MMU-5626467", "R-HSA-216083", "R-GGA-418990", "R-DME-6798695", "R-MMU-5218920", "R-HSA-9927432", "R-DRE-6809371", "R-RNO-5626467", "R-CFA-9764561", "R-HSA-9764302", "R-DME-351906", "R-MMU-418990", "R-HSA-8876493", "R-RNO-9766229", "R-HSA-9856649", "R-MMU-525793", "R-HSA-8957275", "R-HSA-9856530", "R-HSA-9833576", "R-DRE-525793", "R-DME-9013423"], "pathways": ["R-DRE-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-9766229:r:Degradation of CDH1", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-525793:r:Myogenesis", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-418990:r:Adherens junctions interactions", "R-HSA-9764561:r:Regulation of CDH1 Function", "R-DRE-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9823730:r:Formation of definitive endoderm", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CFA-418990:r:Adherens junctions interactions", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-DRE-418990:r:Adherens junctions interactions", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-BTA-418990:r:Adherens junctions interactions", "R-SSC-418990:r:Adherens junctions interactions", "R-DRE-5218920:r:VEGFR2 mediated vascular permeability", "R-CFA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-6805567:r:Keratinization", "R-DRE-9764561:r:Regulation of CDH1 Function", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-GGA-525793:r:Myogenesis", "R-DME-6809371:r:Formation of the cornified envelope", "R-MMU-9762292:r:Regulation of CDH11 function", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-9766229:r:Degradation of CDH1", "R-CFA-1474228:r:Degradation of the extracellular matrix", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9762292:r:Regulation of CDH11 function", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-RNO-418990:r:Adherens junctions interactions", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-CFA-216083:r:Integrin cell surface interactions", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9764561:r:Regulation of CDH1 Function", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-SSC-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-525793:r:Myogenesis", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-CFA-9766229:r:Degradation of CDH1", "R-RNO-9764561:r:Regulation of CDH1 Function", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-216083:r:Integrin cell surface interactions", "R-GGA-418990:r:Adherens junctions interactions", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-DRE-6809371:r:Formation of the cornified envelope", "R-RNO-5626467:r:RHO GTPases activate IQGAPs", "R-CFA-9764561:r:Regulation of CDH1 Function", "R-HSA-9764302:r:Regulation of CDH19 Expression and Function", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-418990:r:Adherens junctions interactions", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-525793:r:Myogenesis", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9833576:r:CDH11 homotypic and heterotypic interactions", "R-DRE-525793:r:Myogenesis", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR039809": {"description": "Chemokine beta/gamma/delta", "go_ids": ["GO:0008009"], "go_terms": ["GO:0008009:chemokine activity:F"], "name": "Chemokine_b/g/d", "pathway_ids": ["R-HSA-6798695", "R-MMU-416476", "R-SSC-6798695", "R-MMU-444473", "R-HSA-9942503", "R-SSC-380108", "R-GGA-418594", "R-HSA-375276", "R-HSA-8936459", "R-HSA-1251985", "R-SSC-114608", "R-MMU-380108", "R-RNO-444473", "R-RNO-140875", "R-BTA-6798695", "R-HSA-2559582", "R-HSA-416476", "R-CFA-380108", "R-GGA-375276", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-BTA-418594", "R-HSA-380994", "R-RNO-202733", "R-MMU-202733", "R-HSA-444473", "R-RNO-416476", "R-HSA-6783783", "R-HSA-9018519", "R-HSA-376176", "R-GGA-114608", "R-HSA-6785807", "R-HSA-140875", "R-MMU-140875", "R-CFA-375276", "R-SSC-375276", "R-HSA-418594", "R-MMU-376176", "R-HSA-380108", "R-HSA-9818026", "R-BTA-380108", "R-CFA-418594", "R-GGA-380108", "R-SSC-418594", "R-MMU-6798695", "R-RNO-380108", "R-HSA-202733", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-9942503:r:Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)", "R-SSC-380108:r:Chemokine receptors bind chemokines", "R-GGA-418594:r:G alpha (i) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-114608:r:Platelet degranulation", "R-MMU-380108:r:Chemokine receptors bind chemokines", "R-RNO-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-416476:r:G alpha (q) signalling events", "R-CFA-380108:r:Chemokine receptors bind chemokines", "R-GGA-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-444473:r:Formyl peptide receptors bind formyl peptides and many other ligands", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-376176:r:Signaling by ROBO receptors", "R-GGA-114608:r:Platelet degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-CFA-375276:r:Peptide ligand-binding receptors", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-380108:r:Chemokine receptors bind chemokines", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-BTA-380108:r:Chemokine receptors bind chemokines", "R-CFA-418594:r:G alpha (i) signalling events", "R-GGA-380108:r:Chemokine receptors bind chemokines", "R-SSC-418594:r:G alpha (i) signalling events", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-380108:r:Chemokine receptors bind chemokines", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR039812": {"description": "Vesicle-fusing ATPase", "go_ids": ["GO:0035494", "GO:0016887"], "go_terms": ["GO:0035494:SNARE complex disassembly:P", "GO:0016887:ATP hydrolysis activity:F"], "name": "Vesicle-fus_ATPase", "pathway_ids": ["R-SPO-6807878", "R-MMU-204005", "R-DME-416993", "R-HSA-6811438", "R-MMU-6811438", "R-SCE-204005", "R-MMU-6807878", "R-DDI-6811434", "R-HSA-6811440", "R-DME-6811438", "R-CEL-6811440", "R-HSA-6811434", "R-CEL-204005", "R-DDI-6811440", "R-CEL-6811438", "R-DME-6807878", "R-MMU-6811434", "R-MMU-416993", "R-SCE-6811440", "R-HSA-416993", "R-DME-6811440", "R-SCE-6807878", "R-DDI-204005", "R-SCE-6811434", "R-RNO-6811440", "R-RNO-6811434", "R-RNO-6807878", "R-RNO-6811438", "R-HSA-6807878", "R-CEL-6807878", "R-SPO-204005", "R-SPO-6811440", "R-RNO-204005", "R-MMU-6811440", "R-DDI-6811438", "R-HSA-204005", "R-DME-6811434", "R-SPO-6811438", "R-DDI-6807878", "R-SPO-6811434", "R-SCE-6811438", "R-CEL-6811434", "R-RNO-416993", "R-DME-204005"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-CEL-6811438:r:Intra-Golgi traffic", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811438:r:Intra-Golgi traffic", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Family"}, "IPR039840": {"description": "N-alpha-acetyltransferase 80", "go_ids": ["GO:0008080"], "go_terms": ["GO:0008080:N-acetyltransferase activity:F"], "name": "NAA80", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR039841": {"description": "Integrator complex subunit 14", "go_ids": ["GO:0032039"], "go_terms": ["GO:0032039:integrator complex:C"], "name": "INTS14", "pathway_ids": ["R-RNO-6807505", "R-BTA-6807505", "R-MMU-6807505", "R-DME-6807505", "R-HSA-6807505", "R-GGA-6807505"], "pathways": ["R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR039842": {"description": "TBC1 domain family member 7", "go_ids": [], "go_terms": [], "name": "TBC1D7", "pathway_ids": ["R-HSA-8854214", "R-XTR-8854214", "R-MMU-8854214", "R-BTA-8854214"], "pathways": ["R-HSA-8854214:r:TBC/RABGAPs", "R-XTR-8854214:r:TBC/RABGAPs", "R-MMU-8854214:r:TBC/RABGAPs", "R-BTA-8854214:r:TBC/RABGAPs"], "type": "Family"}, "IPR039843": {"description": "KxDL motif-containing protein 1-like", "go_ids": [], "go_terms": [], "name": "KXD1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039844": {"description": "Nucleolar pre-ribosomal-associated protein 1", "go_ids": [], "go_terms": [], "name": "URB1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039845": {"description": "PSME3-interacting protein", "go_ids": [], "go_terms": [], "name": "FAM192A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039846": {"description": "Zinc finger CCHC domain-containing protein 4", "go_ids": ["GO:0008988", "GO:0031167"], "go_terms": ["GO:0008988:rRNA (adenine-N6-)-methyltransferase activity:F", "GO:0031167:rRNA methylation:P"], "name": "ZCCHC4", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR039847": {"description": "RING finger protein 37", "go_ids": [], "go_terms": [], "name": "Ubox5", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR039848": {"description": "Small ribosomal subunit protein mS35, mitochondrial", "go_ids": ["GO:0003735", "GO:0032543"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0032543:mitochondrial translation:P"], "name": "Ribosomal_mS35_mt", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-DRE-5389840", "R-BTA-9937383", "R-DRE-5419276"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Family"}, "IPR039852": {"description": "Cullin-associated NEDD8-dissociated protein 1/2", "go_ids": ["GO:0010265"], "go_terms": ["GO:0010265:SCF complex assembly:P"], "name": "CAND1/CAND2", "pathway_ids": ["R-DDI-6798695", "R-BTA-8951664", "R-CEL-917937", "R-HSA-6798695", "R-SPO-6798695", "R-RNO-917937", "R-DDI-917937", "R-CEL-6798695", "R-HSA-8951664", "R-DME-6798695", "R-DME-8951664", "R-BTA-6798695", "R-DDI-8951664", "R-MMU-8951664", "R-MMU-917937", "R-BTA-917937", "R-RNO-8951664", "R-HSA-917937", "R-SPO-917937", "R-MMU-6798695", "R-SPO-8951664", "R-DME-917937", "R-RNO-6798695", "R-CEL-8951664"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-8951664:r:Neddylation", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-917937:r:Iron uptake and transport", "R-DDI-917937:r:Iron uptake and transport", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-8951664:r:Neddylation", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-8951664:r:Neddylation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-MMU-917937:r:Iron uptake and transport", "R-BTA-917937:r:Iron uptake and transport", "R-RNO-8951664:r:Neddylation", "R-HSA-917937:r:Iron uptake and transport", "R-SPO-917937:r:Iron uptake and transport", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-8951664:r:Neddylation", "R-DME-917937:r:Iron uptake and transport", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-8951664:r:Neddylation"], "type": "Family"}, "IPR039853": {"description": "Pinin", "go_ids": [], "go_terms": [], "name": "Pinin", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039856": {"description": "ER membrane protein complex subunit 2-like", "go_ids": [], "go_terms": [], "name": "EMC2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039857": {"description": "Intraflagellar transport protein 122/121 homolog", "go_ids": ["GO:0060271"], "go_terms": ["GO:0060271:cilium assembly:P"], "name": "Ift122/121", "pathway_ids": ["R-HSA-5620924", "R-CEL-5620924", "R-CEL-5610787", "R-HSA-5610787", "R-MMU-5610787", "R-XTR-5610787", "R-RNO-5610787", "R-RNO-5620924", "R-XTR-5620924", "R-MMU-5620924"], "pathways": ["R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-XTR-5610787:r:Hedgehog 'off' state", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-5620924:r:Intraflagellar transport", "R-XTR-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR039859": {"description": "Palmitoyltransferase PFA4/ZDHHC16/ZDHHC20/ERF2-like", "go_ids": ["GO:0016409"], "go_terms": ["GO:0016409:palmitoyltransferase activity:F"], "name": "PFA4/ZDH16/20/ERF2-like", "pathway_ids": ["R-DRE-5683826", "R-BTA-203615", "R-MMU-9648002", "R-HSA-9694548", "R-BTA-9648002", "R-RNO-9009391", "R-MMU-203615", "R-MMU-9009391", "R-RNO-5683826", "R-BTA-9009391", "R-DDI-9648002", "R-HSA-203615", "R-DDI-203615", "R-DME-9648002", "R-SPO-203615", "R-HSA-9009391", "R-DRE-9009391", "R-HSA-5683826", "R-SCE-203615", "R-HSA-9648002", "R-MMU-5683826"], "pathways": ["R-DRE-5683826:r:Surfactant metabolism", "R-BTA-203615:r:eNOS activation", "R-MMU-9648002:r:RAS processing", "R-HSA-9694548:r:Maturation of spike protein", "R-BTA-9648002:r:RAS processing", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203615:r:eNOS activation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-5683826:r:Surfactant metabolism", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-DDI-9648002:r:RAS processing", "R-HSA-203615:r:eNOS activation", "R-DDI-203615:r:eNOS activation", "R-DME-9648002:r:RAS processing", "R-SPO-203615:r:eNOS activation", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5683826:r:Surfactant metabolism", "R-SCE-203615:r:eNOS activation", "R-HSA-9648002:r:RAS processing", "R-MMU-5683826:r:Surfactant metabolism"], "type": "Family"}, "IPR039861": {"description": "Interphotoreceptor matrix proteoglycan", "go_ids": ["GO:0007601"], "go_terms": ["GO:0007601:visual perception:P"], "name": "IMPG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039862": {"description": "N-terminal EF-hand calcium binding protein 1/2/3", "go_ids": [], "go_terms": [], "name": "NECAB1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039863": {"description": "Dickkopf related protein 1-4", "go_ids": [], "go_terms": [], "name": "DKK1-4", "pathway_ids": ["R-HSA-3772470", "R-HSA-201681", "R-MMU-3772470", "R-HSA-5339717"], "pathways": ["R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-5339717:r:Signaling by LRP5 mutants"], "type": "Family"}, "IPR039865": {"description": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "go_ids": ["GO:0035303"], "go_terms": ["GO:0035303:regulation of dephosphorylation:P"], "name": "PPP2R3C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039866": {"description": "Carboxypeptidase Q", "go_ids": ["GO:0070573"], "go_terms": ["GO:0070573:metallodipeptidase activity:F"], "name": "CPQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039867": {"description": "Protein furry/Tao3/Mor2", "go_ids": ["GO:0000902"], "go_terms": ["GO:0000902:cell morphogenesis:P"], "name": "Furry/Tao3/Mor2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039868": {"description": "Armadillo-like helical domain-containing protein 3-like", "go_ids": [], "go_terms": [], "name": "ARMD3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039869": {"description": "Ubiquitin domain-containing protein 1/2", "go_ids": [], "go_terms": [], "name": "UBTD1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039870": {"description": "Cytochrome oxidase assembly factor 4-like", "go_ids": ["GO:0005758", "GO:0033617"], "go_terms": ["GO:0005758:mitochondrial intermembrane space:C", "GO:0033617:mitochondrial respiratory chain complex IV assembly:P"], "name": "Coa4-like", "pathway_ids": ["R-HSA-1268020"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR039871": {"description": "Protein FAM8A1", "go_ids": [], "go_terms": [], "name": "FAM8A1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039872": {"description": "Uncharacterized protein KIAA0513", "go_ids": [], "go_terms": [], "name": "KIAA0513", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039873": {"description": "Coiled-coil domain-containing protein 78", "go_ids": [], "go_terms": [], "name": "CCDC78", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039874": {"description": "Wings apart-like protein", "go_ids": [], "go_terms": [], "name": "WAPL", "pathway_ids": ["R-HSA-2468052", "R-SPO-2500257", "R-MMU-2500257", "R-SPO-2470946", "R-HSA-2500257", "R-HSA-2467813", "R-DME-2470946", "R-MMU-2467813", "R-CEL-2470946", "R-HSA-2470946", "R-DME-2500257", "R-CEL-2468052", "R-MMU-2468052", "R-MMU-2470946", "R-DME-2468052", "R-CEL-2500257"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-2470946:r:Cohesin Loading onto Chromatin", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-DME-2468052:r:Establishment of Sister Chromatid Cohesion", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion"], "type": "Family"}, "IPR039875": {"description": "Leukocyte receptor cluster member 1-like", "go_ids": [], "go_terms": [], "name": "LENG1-like", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039876": {"description": "28kDa heat- and acid-stable phosphoprotein", "go_ids": [], "go_terms": [], "name": "HAP28", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-RNO-6798695", "R-DDI-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR039877": {"description": "Transmembrane protein 131-like", "go_ids": [], "go_terms": [], "name": "TMEM131-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039878": {"description": "RNA-binding protein 33", "go_ids": [], "go_terms": [], "name": "RBM33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039879": {"description": "EF-hand calcium-binding domain-containing protein 10", "go_ids": [], "go_terms": [], "name": "EFC10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039880": {"description": "CHD1 helical C-terminal domain containing protein 1-like", "go_ids": [], "go_terms": [], "name": "CHCT1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039881": {"description": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase PCIF1-like", "go_ids": ["GO:0099122", "GO:0016422"], "go_terms": ["GO:0099122:RNA polymerase II C-terminal domain binding:F", "GO:0016422:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity:F"], "name": "PCIF1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039882": {"description": "Zinc finger protein 414", "go_ids": [], "go_terms": [], "name": "ZN414", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039883": {"description": "Fcf2/DNTTIP2", "go_ids": [], "go_terms": [], "name": "Fcf2/DNTTIP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039884": {"description": "Coiled-coil domain-containing protein R3HC1/R3HCL", "go_ids": [], "go_terms": [], "name": "R3HC1/R3HCL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039885": {"description": "BTBD10/KCTD20, BTB/POZ domain", "go_ids": [], "go_terms": [], "name": "BTBD10/KCTD20_BTB/POZ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR039886": {"description": "BTBD10/KCTD20", "go_ids": [], "go_terms": [], "name": "BTBD10/KCTD20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039887": {"description": "IQ domain-containing protein F", "go_ids": [], "go_terms": [], "name": "IQCF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039888": {"description": "Protein melted-like", "go_ids": [], "go_terms": [], "name": "Melted-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039889": {"description": "Coiled-coil domain-containing protein 33", "go_ids": [], "go_terms": [], "name": "CCD33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039891": {"description": "von Willebrand factor A domain-containing protein 8", "go_ids": [], "go_terms": [], "name": "VWA8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039892": {"description": "Protein Spa2/Sph1", "go_ids": [], "go_terms": [], "name": "Spa2/Sph1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039893": {"description": "Centrosomal protein of 120kDa-like", "go_ids": [], "go_terms": [], "name": "CEP120-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039894": {"description": "tRNA pseudouridine synthase Pus10-like", "go_ids": [], "go_terms": [], "name": "Pus10-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039895": {"description": "Protein cordon-bleu-like", "go_ids": ["GO:0003785"], "go_terms": ["GO:0003785:actin monomer binding:F"], "name": "COBL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039896": {"description": "Protein Red-like", "go_ids": [], "go_terms": [], "name": "Red-like", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-CEL-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039900": {"description": "Pat1-like", "go_ids": ["GO:0000290"], "go_terms": ["GO:0000290:deadenylation-dependent decapping of nuclear-transcribed mRNA:P"], "name": "Pat1-like", "pathway_ids": ["R-SPO-430039", "R-SCE-430039", "R-MMU-430039", "R-RNO-430039", "R-CEL-430039", "R-DRE-430039", "R-HSA-430039"], "pathways": ["R-SPO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-RNO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-CEL-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Family"}, "IPR039901": {"description": "3-deoxy-D-manno-octulosonic acid transferase", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "Kdotransferase", "pathway_ids": ["PWY-8074", "PWY-8246", "PWY-8284", "PWY-7675"], "pathways": ["PWY-8074:t:Kdo transfer to lipid IVA (P. putida)", "PWY-8246:t:Kdo transfer to lipid IVA (P. gingivalis)", "PWY-8284:t:Kdo transfer to lipid IVA (Vibrio cholerae serogroup O1 El Tor)", "PWY-7675:t:Kdo transfer to lipid IVA (Haemophilus)"], "type": "Family"}, "IPR039902": {"description": "Coiled-coil domain-containing protein CCDC148/CCDC112", "go_ids": [], "go_terms": [], "name": "CCDC148/CCDC112", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039903": {"description": "E3 ubiquitin-protein ligase Zswim2", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "Zswim2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039904": {"description": "TPR and ankyrin repeat-containing protein 1", "go_ids": [], "go_terms": [], "name": "TRANK1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039905": {"description": "CD2 antigen cytoplasmic tail-binding protein 2/Lin1", "go_ids": ["GO:0005682"], "go_terms": ["GO:0005682:U5 snRNP:C"], "name": "CD2BP2/Lin1", "pathway_ids": ["R-HSA-9918481"], "pathways": ["R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR039907": {"description": "RNA-binding protein NOB1", "go_ids": [], "go_terms": [], "name": "NOB1", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR039908": {"description": "Protein sepa-1", "go_ids": ["GO:0006914"], "go_terms": ["GO:0006914:autophagy:P"], "name": "Sepa-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039910": {"description": "Surface antigen D15-like", "go_ids": [], "go_terms": [], "name": "D15-like", "pathway_ids": ["R-XTR-9013404", "R-HSA-1268020", "R-BTA-9013404", "R-RNO-9013404", "R-HSA-9760173", "R-DRE-9013404", "R-MMU-9013404", "R-HSA-8949613", "R-HSA-9013404"], "pathways": ["R-XTR-9013404:r:RAC2 GTPase cycle", "R-HSA-1268020:r:Mitochondrial protein import", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9760173:r:Secretion of toxins", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-8949613:r:Cristae formation", "R-HSA-9013404:r:RAC2 GTPase cycle"], "type": "Family"}, "IPR039911": {"description": "JNK-interacting protein 3/4", "go_ids": ["GO:0005078"], "go_terms": ["GO:0005078:MAP kinase scaffold activity:F"], "name": "JIP3/JIP4", "pathway_ids": ["R-HSA-525793", "R-MMU-525793", "R-CEL-525793", "R-DME-525793"], "pathways": ["R-HSA-525793:r:Myogenesis", "R-MMU-525793:r:Myogenesis", "R-CEL-525793:r:Myogenesis", "R-DME-525793:r:Myogenesis"], "type": "Family"}, "IPR039913": {"description": "RNA polymerase II-associated protein RPAP1/Rba50", "go_ids": ["GO:0006366"], "go_terms": ["GO:0006366:transcription by RNA polymerase II:P"], "name": "RPAP1/Rba50", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039914": {"description": "Signal recognition particle SRP9-like", "go_ids": ["GO:0006614", "GO:0048500"], "go_terms": ["GO:0006614:SRP-dependent cotranslational protein targeting to membrane:P", "GO:0048500:signal recognition particle:C"], "name": "SRP9-like", "pathway_ids": ["R-HSA-1799339", "R-MMU-1799339", "R-DME-1799339", "R-DDI-1799339", "R-CEL-1799339", "R-SPO-1799339", "R-SCE-1799339"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane"], "type": "Family"}, "IPR039915": {"description": "TACC family", "go_ids": ["GO:0007052"], "go_terms": ["GO:0007052:mitotic spindle organization:P"], "name": "TACC", "pathway_ids": ["R-HSA-9604323", "R-HSA-9013507"], "pathways": ["R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus"], "type": "Family"}, "IPR039916": {"description": "Exophilin-5", "go_ids": [], "go_terms": [], "name": "EXPH5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039918": {"description": "Serine/threonine-protein phosphatase 4 regulatory subunit 4", "go_ids": [], "go_terms": [], "name": "PPP4R4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039919": {"description": "Rho guanine nucleotide exchange factor 10/17", "go_ids": 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signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CEL-193648:r:NRAGE signals death through JNK"], "type": "Family"}, "IPR039920": {"description": "DNA repair/transcription protein MMS19", "go_ids": ["GO:0051604"], "go_terms": ["GO:0051604:protein maturation:P"], "name": "MMS19", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Family"}, "IPR039921": {"description": "Inscuteable", "go_ids": ["GO:0008356"], "go_terms": ["GO:0008356:asymmetric cell division:P"], "name": "Inscuteable", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039922": {"description": "GDP-fucose protein O-fucosyltransferase 1", "go_ids": ["GO:0007219", "GO:0046922", "GO:0036066"], "go_terms": ["GO:0007219:Notch signaling pathway:P", "GO:0046922:peptide-O-fucosyltransferase activity:F", "GO:0036066:protein O-linked glycosylation via fucose:P"], "name": "POFUT1", "pathway_ids": ["R-HSA-1912399"], "pathways": ["R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum"], "type": "Family"}, "IPR039923": {"description": "Protodermal factor 1", "go_ids": [], "go_terms": [], "name": "Protodermal_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039924": {"description": "Protein ICln/Lot5/Saf5", "go_ids": [], "go_terms": [], "name": "ICln/Lot5/Saf5", "pathway_ids": ["R-MMU-191859", "R-RNO-191859", "R-HSA-191859"], "pathways": ["R-MMU-191859:r:snRNP Assembly", "R-RNO-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly"], "type": "Family"}, "IPR039926": {"description": "Protein egg apparatus-1", "go_ids": [], "go_terms": [], "name": "Egg_app_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039927": {"description": "Large ribosomal subunit protein mL43", "go_ids": ["GO:0032543", "GO:0003735"], "go_terms": ["GO:0032543:mitochondrial translation:P", "GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_mL43", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR039928": {"description": "LNK family", "go_ids": ["GO:0007623", "GO:0006355"], "go_terms": ["GO:0007623:circadian rhythm:P", "GO:0006355:regulation of DNA-templated 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"R-MMU-9927354:r:Co-stimulation by ICOS", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-CFA-9927354:r:Co-stimulation by ICOS", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "type": "Family"}, "IPR039945": {"description": "Lymphocyte antigen 86", "go_ids": ["GO:0006955"], "go_terms": ["GO:0006955:immune response:P"], "name": "LY86", "pathway_ids": ["R-MMU-166016", "R-HSA-166016"], "pathways": ["R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", 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"R-DDI-6796648", "R-SPO-6796648", "R-SCE-983168", "R-BTA-6796648", "R-SCE-6796648", "R-HSA-1234176", "R-BTA-9705462", "R-BTA-75955", "R-MMU-6796648", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-RNO-9705462", "R-BTA-674695", "R-HSA-983168", "R-MMU-674695", "R-MMU-1234176", "R-MMU-9705462", "R-HSA-180585", "R-DDI-983168", "R-HSA-167290", "R-HSA-167200", "R-RNO-112382", "R-HSA-75955", "R-RNO-8951664", "R-HSA-9705462", "R-RNO-9954709", "R-MMU-983168", "R-BTA-9954709", "R-HSA-674695", "R-RNO-983168", "R-HSA-112382"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-8951664:r:Neddylation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-8951664:r:Neddylation", "R-BTA-1234176:r:Oxygen-dependent 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"R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-8951664:r:Neddylation", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Family"}, "IPR039949": {"description": 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"type": "Family"}, "IPR039962": {"description": "Uncharacterized protein ZC21.8", "go_ids": [], "go_terms": [], "name": "ZC21.8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039963": {"description": "Uncharacterized 22kDa protein in aldolase locus", "go_ids": [], "go_terms": [], "name": "Unchar_22kDa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039964": {"description": "Uncharacterized protein KIAA0040-like", "go_ids": [], "go_terms": [], "name": "KIAA0040-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039965": {"description": "Uncharacterized protein C3H7.08c", "go_ids": [], "go_terms": [], "name": "C3H7.08c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039966": {"description": "Uncharacterized protein C553.12c", "go_ids": [], "go_terms": [], "name": "C553.12c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039967": {"description": "Uncharacterized protein MJ1020-like", "go_ids": [], "go_terms": [], "name": 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"pathway_ids": ["R-HSA-9913351", "R-CFA-9913351", "R-MMU-9913351", "R-BTA-9913351"], "pathways": ["R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-CFA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-BTA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Family"}, "IPR039974": {"description": "Pre-mRNA-splicing factor SLU7", "go_ids": ["GO:0030628", "GO:0000398"], "go_terms": ["GO:0030628:pre-mRNA 3'-splice site binding:F", "GO:0000398:mRNA splicing, via spliceosome:P"], "name": "Splicing_factor_SLU7", "pathway_ids": ["R-CEL-159236", "R-MMU-72163", "R-HSA-73856", "R-BTA-73856", "R-MMU-73856", "R-RNO-72163", "R-HSA-72187", "R-CEL-73856", "R-DDI-72163", "R-DME-159236", "R-DME-72163", "R-MMU-159236", "R-RNO-73856", "R-DRE-72163", "R-HSA-72163", "R-DRE-159236", "R-DRE-73856", "R-MMU-72187", "R-RNO-159236", "R-BTA-159236", "R-HSA-159236", "R-DME-73856", "R-CEL-72163", "R-BTA-72163"], "pathways": ["R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039975": {"description": "Intraflagellar transport protein 52 homolog", "go_ids": [], "go_terms": [], "name": "IFT52", "pathway_ids": ["R-MMU-5610787", "R-MMU-5620924", "R-HSA-5610787", "R-HSA-5620924"], "pathways": ["R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR039976": {"description": "WPP domain-interacting tail-anchored protein", "go_ids": [], "go_terms": [], "name": "WIT1/WIT2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039977": {"description": "Histone-lysine N-methyltransferase Suv4-20/Set9", "go_ids": [], "go_terms": [], "name": "Suv4-20/Set9", "pathway_ids": ["R-HSA-3214841", "R-DME-3214841", "R-MMU-3214841", "R-DRE-3214841", "R-SPO-3214841", "R-RNO-3214841"], "pathways": ["R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DME-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-SPO-3214841:r:PKMTs methylate histone lysines", "R-RNO-3214841:r:PKMTs methylate histone lysines"], "type": "Family"}, "IPR039979": {"description": "Pre-mRNA-splicing factor 18", "go_ids": ["GO:0008380"], "go_terms": ["GO:0008380:RNA splicing:P"], "name": "PRPF18", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR039980": {"description": "MAP kinase-activating death domain protein", "go_ids": [], "go_terms": [], "name": "MADD", "pathway_ids": ["R-RNO-8876198", "R-RNO-5357905", "R-HSA-8876198", "R-HSA-5357905", "R-MMU-8876198", "R-CEL-8876198", "R-DME-8876198", "R-MMU-5357905"], "pathways": ["R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5357905:r:Regulation of TNFR1 signaling"], "type": "Family"}, "IPR039982": {"description": "Large ribosomal subunit protein mL65", "go_ids": ["GO:0003735"], "go_terms": ["GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_mL65", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR039983": {"description": "Cholesterol 24-hydroxylase", "go_ids": ["GO:0020037", "GO:0005506", "GO:0006707", "GO:0033781"], "go_terms": ["GO:0020037:heme binding:F", "GO:0005506:iron ion binding:F", "GO:0006707:cholesterol catabolic process:P", "GO:0033781:cholesterol 24-hydroxylase activity:F"], "name": "CYP46A1", "pathway_ids": ["R-MMU-211976", "R-HSA-211976", "R-MMU-193775", "R-HSA-193775"], "pathways": ["R-MMU-211976:r:Endogenous sterols", "R-HSA-211976:r:Endogenous sterols", "R-MMU-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "type": "Family"}, "IPR039986": {"description": "Cilia- and flagella- associated protein 210", "go_ids": [], "go_terms": [], "name": "CFAP210", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039987": {"description": "PGR5-like protein 1", "go_ids": ["GO:0009773", "GO:0009535", "GO:0016730"], "go_terms": ["GO:0009773:photosynthetic electron transport in photosystem I:P", "GO:0009535:chloroplast thylakoid membrane:C", "GO:0016730:oxidoreductase activity, acting on iron-sulfur proteins as donors:F"], "name": "PGRL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039988": {"description": "Microsomal triglyceride transfer protein large subunit", "go_ids": ["GO:0120014"], "go_terms": ["GO:0120014:phospholipid transfer activity:F"], "name": "MTTP", "pathway_ids": ["R-RNO-8963888", "R-MMU-8866423", "R-SSC-8963888", "R-MMU-8963888", "R-MMU-8964041", "R-HSA-8866423", "R-RNO-8866423", "R-RNO-8964041", "R-SSC-8866423", "R-DME-8964041", "R-HSA-8963888", "R-HSA-8964041", "R-CEL-8964041", "R-SSC-8964041", "R-DRE-8964041"], "pathways": ["R-RNO-8963888:r:Chylomicron assembly", "R-MMU-8866423:r:VLDL assembly", "R-SSC-8963888:r:Chylomicron assembly", "R-MMU-8963888:r:Chylomicron assembly", "R-MMU-8964041:r:LDL remodeling", "R-HSA-8866423:r:VLDL assembly", "R-RNO-8866423:r:VLDL assembly", "R-RNO-8964041:r:LDL remodeling", "R-SSC-8866423:r:VLDL assembly", "R-DME-8964041:r:LDL remodeling", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-CEL-8964041:r:LDL remodeling", "R-SSC-8964041:r:LDL remodeling", "R-DRE-8964041:r:LDL remodeling"], "type": "Family"}, "IPR039989": {"description": "ADP-ribose pyrophosphatase, mitochondrial", "go_ids": ["GO:0047631"], "go_terms": ["GO:0047631:ADP-ribose diphosphatase activity:F"], "name": "NUDT9", "pathway_ids": ["R-HSA-2393930", "R-CEL-2393930", "R-MMU-2393930", "R-RNO-2393930"], "pathways": ["R-HSA-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-CEL-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-MMU-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-RNO-2393930:r:Phosphate bond hydrolysis by NUDT proteins"], "type": "Family"}, "IPR039991": {"description": "Protein shortage in chiasmata 1 ortholog", "go_ids": ["GO:0016887", "GO:0000712", "GO:0000794"], "go_terms": ["GO:0016887:ATP hydrolysis activity:F", "GO:0000712:resolution of meiotic recombination intermediates:P", "GO:0000794:condensed nuclear chromosome:C"], "name": "SHOC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039992": {"description": "Selenoprotein F/M", "go_ids": [], "go_terms": [], "name": "Sep15_SelM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039993": {"description": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10", "go_ids": [], "go_terms": [], "name": "NDUFB10", "pathway_ids": ["R-HSA-611105", "R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-BTA-611105", "R-MMU-611105"], "pathways": ["R-HSA-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR039994": {"description": "Histone lysine demethylase/ribosomal histidine hydroxylase NO66-like", "go_ids": [], "go_terms": [], "name": "NO66-like", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-RNO-9629569", "R-RNO-3214842", "R-MMU-9629569", "R-MMU-3214842", "R-DDI-9629569", "R-HSA-3214842", "R-DRE-9629569", "R-CEL-9629569", "R-DME-9629569", "R-GGA-9629569", "R-BTA-9629569", "R-HSA-9629569"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-RNO-9629569:r:Protein hydroxylation", "R-RNO-3214842:r:HDMs demethylate histones", "R-MMU-9629569:r:Protein hydroxylation", "R-MMU-3214842:r:HDMs demethylate histones", "R-DDI-9629569:r:Protein hydroxylation", "R-HSA-3214842:r:HDMs demethylate histones", "R-DRE-9629569:r:Protein hydroxylation", "R-CEL-9629569:r:Protein hydroxylation", "R-DME-9629569:r:Protein hydroxylation", "R-GGA-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Family"}, "IPR039995": {"description": "Peroxisomal biogenesis factor 39", "go_ids": [], "go_terms": [], "name": "PEX39", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039996": {"description": "Shieldin complex subunit 3", "go_ids": ["GO:0010569"], "go_terms": ["GO:0010569:regulation of double-strand break repair via homologous recombination:P"], "name": "Shieldin_RINN1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR039997": {"description": "Transcription factor E", "go_ids": [], "go_terms": [], "name": "TFE", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-BTA-73776", "R-MMU-75953", "R-SCE-75953", "R-BTA-76042", "R-DDI-73776", "R-SPO-6807505", "R-HSA-167162", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-MMU-73776", "R-DDI-76042", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-BTA-73779", "R-SPO-75953", "R-SCE-73779", "R-BTA-75953", "R-DDI-73779", "R-BTA-674695", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-HSA-167161", "R-SCE-674695", "R-SPO-73779", "R-HSA-674695", "R-HSA-76042", "R-DDI-75953", "R-BTA-6807505", "R-SPO-73776", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167161:r:HIV Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Family"}, "IPR039999": {"description": "Cell growth-regulating nucleolar protein", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "LYAR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040000": {"description": "Nucleolar protein 9", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "NOP9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040002": {"description": "U6 snRNA-associated Sm-like protein Lsm3", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "Sm-like_LSM3", "pathway_ids": ["R-SCE-430039", "R-SPO-430039", "R-HSA-72163", "R-MMU-430039", "R-DDI-430039", "R-MMU-72163", "R-HSA-430039"], "pathways": ["R-SCE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-SPO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DDI-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Family"}, "IPR040003": {"description": "Plastoglobular protein 18-like", "go_ids": ["GO:0010027"], "go_terms": ["GO:0010027:thylakoid membrane organization:P"], "name": "PG18-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040004": {"description": "Single-pass membrane and coiled-coil domain-containing protein 3", "go_ids": [], "go_terms": [], "name": "SMCO3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040005": {"description": "RNA polymerase I subunit H", "go_ids": [], "go_terms": [], "name": "Polr1has", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040006": {"description": "Tankyrase 1-binding protein-like", "go_ids": [], "go_terms": [], "name": "TNKS1BP1-like", "pathway_ids": ["R-MMU-6804115", "R-HSA-6804115", "R-MMU-429947", "R-HSA-429947", "R-HSA-9820841"], "pathways": ["R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Family"}, "IPR040007": {"description": "THO complex subunit 2", "go_ids": ["GO:0006397", "GO:0006406", "GO:0000347"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:0006406:mRNA export from nucleus:P", "GO:0000347:THO complex:C"], "name": "Tho2", "pathway_ids": ["R-MMU-73856", "R-HSA-73856", "R-HSA-159236", "R-HSA-72187", "R-MMU-72187", "R-MMU-159236"], "pathways": ["R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR040008": {"description": "Large ribosomal subunit protein mL46", "go_ids": ["GO:0003735"], "go_terms": ["GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_mL46", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-BTA-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR040009": {"description": "Protein Mtf2/C5D6.12-like", "go_ids": [], "go_terms": [], "name": "Mtf2/C5D6.12-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040010": {"description": "ZNF608/609", "go_ids": [], "go_terms": [], "name": "ZN608/ZN609", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040012": {"description": "Cell surface glycoprotein CD200 receptor", "go_ids": ["GO:0038023", "GO:0150077"], "go_terms": ["GO:0038023:signaling receptor activity:F", "GO:0150077:regulation of neuroinflammatory response:P"], "name": "CD200R", "pathway_ids": ["R-HSA-198933", "R-GGA-198933", "R-MMU-198933", "R-BTA-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a 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"go_ids": ["GO:0006409", "GO:0000049", "GO:0071528", "GO:0031267"], "go_terms": ["GO:0006409:tRNA export from nucleus:P", "GO:0000049:tRNA binding:F", "GO:0071528:tRNA re-export from nucleus:P", "GO:0031267:small GTPase binding:F"], "name": "XPOT", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR040019": {"description": "Uncharacterized protein C27D6.3-like", "go_ids": [], "go_terms": [], "name": "C27D6.3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040020": {"description": "Uncharacterized protein C13orf46-like", "go_ids": [], "go_terms": [], "name": "C13orf46-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040022": {"description": "Uncharacterized protein C9orf153-like", "go_ids": [], "go_terms": [], "name": "C9orf153-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040023": {"description": "WW domain-binding protein 4", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "WBP4", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR040024": {"description": "Protein phosphatase 1 regulatory subunit 21", "go_ids": [], "go_terms": [], "name": "PPP1R21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040025": {"description": "Zinc finger protein 622/Rei1/Reh1", "go_ids": [], "go_terms": [], "name": "Znf622/Rei1/Reh1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040026": {"description": "Flagellar hook-associated protein 2", "go_ids": ["GO:0009421"], "go_terms": ["GO:0009421:bacterial-type flagellum filament cap:C"], "name": "FliD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040027": {"description": "Uncharacterized protein C11orf91-like", "go_ids": [], "go_terms": [], "name": "C11orf91-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040028": {"description": "Intraflagellar transport-associated protein", "go_ids": [], "go_terms": [], "name": "IFTAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040029": {"description": "Dopamine receptor-interacting protein 1", "go_ids": [], "go_terms": [], "name": "C14orf28-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040030": {"description": "Large ribosomal subunit protein mL57", "go_ids": ["GO:0032543", "GO:0005762", "GO:0003735"], "go_terms": ["GO:0032543:mitochondrial translation:P", "GO:0005762:mitochondrial large ribosomal subunit:C", "GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_mL57", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040031": {"description": "Codanin-1", "go_ids": [], "go_terms": [], "name": "Codanin-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040032": {"description": "DENN domain-containing protein 1A/1B/1C", "go_ids": ["GO:0005085"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "DENND1A/B/C", "pathway_ids": ["R-HSA-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR040034": {"description": "Centromere protein H", "go_ids": ["GO:0000776", "GO:0051382"], "go_terms": ["GO:0000776:kinetochore:C", "GO:0051382:kinetochore assembly:P"], "name": "CENP-H", "pathway_ids": ["R-MMU-2500257", "R-HSA-606279", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-MMU-606279", "R-BTA-5663220", "R-HSA-9648025", "R-MMU-68877", "R-BTA-606279", "R-GGA-2500257", "R-GGA-141444", "R-BTA-2467813", "R-HSA-68877", "R-GGA-9648025", "R-GGA-606279", "R-BTA-2500257", "R-GGA-5663220", "R-HSA-5663220", "R-GGA-2467813", "R-BTA-9648025", "R-BTA-141444", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-BTA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", 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"GO:0043565:sequence-specific DNA binding:F", "GO:0005634:nucleus:C"], "name": "CYCLOPS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040038": {"description": "TIPIN/Csm3/Swi3", "go_ids": ["GO:0000076"], "go_terms": ["GO:0000076:DNA replication checkpoint signaling:P"], "name": "TIPIN/Csm3/Swi3", "pathway_ids": ["R-HSA-5693607", "R-MMU-5693607", "R-GGA-5693607"], "pathways": ["R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-GGA-5693607:r:Processing of DNA double-strand break ends"], "type": "Family"}, "IPR040039": {"description": "Phosphatidylinositol-glycan biosynthesis class X protein", "go_ids": ["GO:0006506"], "go_terms": ["GO:0006506:GPI anchor biosynthetic process:P"], "name": "PIGX", "pathway_ids": ["R-HSA-162710", "R-RNO-162710", "R-MMU-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-RNO-162710:r:Synthesis of glycosylphosphatidylinositol 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"pathways": ["PWY-622:t:starch biosynthesis", "PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)", "PWY-5067:t:glycogen biosynthesis II (from UDP-D-Glucose)"], "type": "Family"}, "IPR040043": {"description": "Actin maturation protease", "go_ids": [], "go_terms": [], "name": "ACTMAP", "pathway_ids": ["PWY-7694", "PWY-6423", "PWY-7954"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-6423:t:hemoglobin degradation", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis"], "type": "Family"}, "IPR040044": {"description": "SRR1-like protein", "go_ids": [], "go_terms": [], "name": "SRR1L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040045": {"description": "Cytoplasmic dynein 2 light intermediate chain 1", "go_ids": ["GO:0035721", "GO:0035735", "GO:0005868"], "go_terms": ["GO:0035721:intraciliary retrograde transport:P", "GO:0035735:intraciliary transport involved in cilium assembly:P", "GO:0005868:cytoplasmic dynein complex:C"], "name": "DYNC2LI1", "pathway_ids": ["R-BTA-5620924", "R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-BTA-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Family"}, "IPR040046": {"description": "Protein FAM228", "go_ids": [], "go_terms": [], "name": "FAM228", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040047": {"description": "Syndetin", "go_ids": ["GO:1990745", "GO:0032456", "GO:0042147"], "go_terms": ["GO:1990745:EARP complex:C", "GO:0032456:endocytic recycling:P", "GO:0042147:retrograde transport, endosome to Golgi:P"], "name": "VPS50", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040048": {"description": "Zinc finger protein 277", "go_ids": [], "go_terms": [], "name": "ZNF277", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040049": {"description": "Ribosomal subunit protein mS25/mL61, mitochondrial", "go_ids": ["GO:0005739", "GO:0003735"], "go_terms": ["GO:0005739:mitochondrion:C", "GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_mS25/mL61", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-CEL-5389840", "R-HSA-9937383", "R-BTA-9937383", "R-BTA-5389840", "R-CEL-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-DME-5389840", "R-HSA-5389840", "R-RNO-9937383", "R-MMU-5389840", "R-DME-9937383", "R-RNO-5389840"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR040050": {"description": "Zinc finger protein 830-like", "go_ids": ["GO:0003676", "GO:0008270", "GO:0005681"], "go_terms": ["GO:0003676:nucleic acid binding:F", "GO:0008270:zinc ion binding:F", "GO:0005681:spliceosomal complex:C"], "name": "ZNF830-like", "pathway_ids": ["R-RNO-6781823", "R-HSA-72163", "R-MMU-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-XTR-6782210", "R-MMU-72163", "R-RNO-6782135", "R-XTR-6782135", "R-HSA-6782210", "R-RNO-72163", "R-XTR-72163", "R-MMU-6782210", "R-XTR-6781823", "R-HSA-6782135", "R-HSA-6781823", "R-RNO-6782210"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-XTR-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6782135:r:Dual incision in TC-NER", "R-XTR-6782135:r:Dual incision in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER"], "type": "Family"}, "IPR040051": {"description": "Selenocysteine insertion sequence-binding protein 2", "go_ids": ["GO:0035368"], "go_terms": ["GO:0035368:selenocysteine insertion sequence binding:F"], "name": "SECISBP2", "pathway_ids": ["R-HSA-2408557"], "pathways": ["R-HSA-2408557:r:Selenocysteine synthesis"], "type": "Family"}, "IPR040052": {"description": "Splicing factor 45", "go_ids": ["GO:0045292"], "go_terms": ["GO:0045292:mRNA cis splicing, via spliceosome:P"], "name": "RBM17", "pathway_ids": ["R-HSA-72163", "R-HSA-9770562", "R-HSA-9918481", "R-MMU-9770562", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR040053": {"description": "Josephin-1/2", "go_ids": ["GO:0004843"], "go_terms": ["GO:0004843:cysteine-type deubiquitinase activity:F"], "name": "JOSD1/2", "pathway_ids": ["R-RNO-5689877", "R-DME-5689877", "R-MMU-5689877", "R-HSA-5689877"], "pathways": ["R-RNO-5689877:r:Josephin domain DUBs", "R-DME-5689877:r:Josephin domain DUBs", "R-MMU-5689877:r:Josephin domain DUBs", "R-HSA-5689877:r:Josephin domain DUBs"], "type": "Family"}, "IPR040054": {"description": "Small ribosomal subunit protein mS40", "go_ids": ["GO:0003735", "GO:0032543"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0032543:mitochondrial translation:P"], "name": "MRPS18B", "pathway_ids": ["R-SSC-9937383", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-SSC-5419276", "R-MMU-5419276", "R-HSA-9937383", "R-SSC-5389840", "R-HSA-5389840", "R-MMU-5389840"], "pathways": ["R-SSC-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-SSC-5419276:r:Mitochondrial translation termination", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-SSC-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation"], "type": "Family"}, "IPR040055": {"description": "Small ribosomal subunit protein uS10m", "go_ids": ["GO:0005763"], "go_terms": ["GO:0005763:mitochondrial small ribosomal subunit:C"], "name": "Ribosomal_uS10m", "pathway_ids": ["R-MMU-9837999", "R-HSA-5419276", "R-MMU-9937383", "R-CEL-9837999", "R-CEL-5389840", "R-DME-9837999", "R-HSA-9937383", "R-RNO-9837999", "R-DRE-5389840", "R-BTA-9937383", "R-DRE-9837999", "R-BTA-5389840", "R-CEL-9937383", "R-DRE-9937383", "R-HSA-5368286", "R-RNO-5419276", "R-BTA-9837999", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9837999", "R-CEL-5419276", "R-HSA-5389840", "R-RNO-9937383", "R-DME-5389840", "R-MMU-5389840", "R-DME-9937383", "R-RNO-5389840", "R-DRE-5419276"], "pathways": ["R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9837999:r:Mitochondrial protein degradation", "R-BTA-5389840:r:Mitochondrial translation elongation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-RNO-5419276:r:Mitochondrial translation termination", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation 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"type": "Family"}, "IPR040065": {"description": "Protein LZIC", "go_ids": [], "go_terms": [], "name": "LZIC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040066": {"description": "WD repeat-containing protein 31", "go_ids": [], "go_terms": [], "name": "WDR31", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040067": {"description": "WDR47", "go_ids": [], "go_terms": [], "name": "WDR47", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040070": {"description": "Immunity-related GTPase family Q protein", "go_ids": [], "go_terms": [], "name": "IRGQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040072": {"description": "Methyltransferase (Class A)", "go_ids": [], "go_terms": [], "name": "Methyltransferase_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040074": {"description": "BssD/PflA/YjjW", "go_ids": [], "go_terms": [], "name": "BssD/PflA/YjjW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040076": {"description": "Alba-like/SkfB-like", "go_ids": [], "go_terms": [], "name": "Alba/SkfB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040078": {"description": "CTD small RNA polymerase II polypeptide A phosphatase-like", "go_ids": ["GO:0008420"], "go_terms": ["GO:0008420:RNA polymerase II CTD heptapeptide repeat phosphatase activity:F"], "name": "RNA_Pol_CTD_Phosphatase", "pathway_ids": ["R-SPO-113418", "R-HSA-381038", "R-SPO-6796648", "R-SPO-674695"], "pathways": ["R-SPO-113418:r:Formation of the Early Elongation Complex", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Family"}, "IPR040079": {"description": "Glutathione transferase family", "go_ids": [], "go_terms": [], "name": "Glutathione_S-Trfase", "pathway_ids": ["PWY-6842", "PWY-7533", "PWY-7112", "PWY-4061", "R-CEL-156581", "R-HSA-6798695", "R-HSA-8963684", "R-MMU-9753281", "R-RNO-9753281", "R-CEL-6798695", "R-DME-8963684", "R-DME-2162123", "R-MMU-9013404", "R-RNO-3299685", "R-MMU-156590", "R-PFA-156590", "R-MMU-189483", "R-HSA-9662360", "R-RNO-8963684", "R-HSA-1268020", "R-DRE-6798695", "R-HSA-196836", "R-RNO-156581", "R-DME-196836", "R-MMU-9603798", "R-DME-156842", "R-RNO-189483", "R-RNO-9026762", "R-RNO-9748787", "R-SSC-196836", "R-MMU-9748787", "R-DME-204174", "R-MMU-156842", "R-HSA-3299685", "R-PFA-2162123", "R-RNO-2162123", "R-HSA-8950505", "R-MMU-3299685", "R-MMU-156581", "R-HSA-8949613", "R-HSA-9013404", "R-GGA-9748787", "R-MMU-204174", "R-RNO-156590", "R-DRE-2162123", "R-HSA-9748787", "R-BTA-9748787", "R-SSC-156590", "R-SCE-156842", "R-MMU-6798695", "R-CEL-9753281", "R-DDI-2162123", "R-DDI-204174", "R-RNO-6798695", "R-HSA-9818027", "R-SSC-9013404", "R-DME-156581", "R-CEL-196836", "R-RNO-196836", "R-HSA-2672351", "R-HSA-156590", "R-HSA-189483", "R-RNO-2672351", "R-HSA-9725370", "R-BTA-189483", "R-MMU-8963684", "R-BTA-156590", "R-HSA-5578775", "R-HSA-9603798", "R-HSA-2162123", "R-GGA-2162123", "R-HSA-204174", "R-MMU-196836", "R-DME-156590", "R-RNO-204174", "R-BTA-9603798", "R-HSA-156842", "R-RNO-5578775", "R-RNO-156842", "R-CEL-204174", "R-MMU-2162123", "R-HSA-9662361", "R-SSC-156581", "R-HSA-9753281", "R-CEL-3299685", "R-GGA-156590", "R-CEL-8963684", "R-DDI-8963684", "R-MMU-9026762", "R-CEL-156590", "R-HSA-156581", "R-BTA-9753281", "R-HSA-9026762", "R-DDI-156590"], "pathways": ["PWY-6842:t:glutathione-mediated detoxification II", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7112:t:4-hydroxy-2-nonenal detoxification", "PWY-4061:t:glutathione-mediated detoxification I", "R-CEL-156581:r:Methylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8963684:r:Tyrosine catabolism", "R-MMU-9753281:r:Paracetamol ADME", "R-RNO-9753281:r:Paracetamol ADME", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-8963684:r:Tyrosine catabolism", "R-DME-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-9013404:r:RAC2 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"R-CEL-156590:r:Glutathione conjugation", "R-HSA-156581:r:Methylation", "R-BTA-9753281:r:Paracetamol ADME", "R-HSA-9026762:r:Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "R-DDI-156590:r:Glutathione conjugation"], "type": "Family"}, "IPR040081": {"description": "Chondrochloren A methyltransferase (CndI-like)", "go_ids": [], "go_terms": [], "name": "CndI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040082": {"description": "Gentamicin C-6' methyltransferase (GenK-like)", "go_ids": [], "go_terms": [], "name": "GenK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040084": {"description": "GTPase Obg", "go_ids": [], "go_terms": [], "name": "GTPase_Obg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040085": {"description": "Protein MJ0674-like", "go_ids": [], "go_terms": [], "name": "MJ0674-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040086": {"description": "Protein MJ0683-like", "go_ids": [], 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homologue 1/2/3/4", "go_ids": [], "go_terms": [], "name": "Lbp1-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040095": {"description": "KRBA1", "go_ids": [], "go_terms": [], "name": "KRBA1", "pathway_ids": ["R-MMU-212436", "R-HSA-212436"], "pathways": ["R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway"], "type": "Family"}, "IPR040096": {"description": "RAB6A-GEF complex partner protein 1", "go_ids": ["GO:0034066", "GO:0006886"], "go_terms": ["GO:0034066:Ric1-Rgp1 guanyl-nucleotide exchange factor complex:C", "GO:0006886:intracellular protein transport:P"], "name": "Ric1", "pathway_ids": ["R-CEL-6811440", "R-SCE-6811440", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-CEL-8876198", "R-MMU-8876198", "R-HSA-6811440", "R-DME-8876198", "R-CEL-6811438", "R-HSA-8876198", "R-SPO-6811440", "R-SPO-8876198", "R-SCE-8876198", "R-MMU-6811440"], "pathways": ["R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SCE-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-6811438:r:Intra-Golgi traffic", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR040099": {"description": "Zinc finger ZZ-type and EF-hand domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "ZZEF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040102": {"description": "WD repeat-containing protein 41", "go_ids": ["GO:0010506"], "go_terms": ["GO:0010506:regulation of autophagy:P"], "name": "WDR41", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040107": {"description": "U4/U6.U5 small nuclear ribonucleoprotein component Snu23", "go_ids": ["GO:0000398", "GO:0005681"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P", "GO:0005681:spliceosomal complex:C"], "name": "Snu23", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-CEL-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR040108": {"description": "Laa1/Sip1/HEATR5", "go_ids": [], "go_terms": [], "name": "Laa1/Sip1/HEATR5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040111": {"description": "Outer dynein arm-docking complex subunit 4", "go_ids": [], "go_terms": [], "name": "ODAD4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040112": {"description": "Developmental regulatory protein WetA", "go_ids": [], "go_terms": [], "name": "WetA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040115": {"description": "Lunapark family", "go_ids": ["GO:0071786"], "go_terms": ["GO:0071786:endoplasmic reticulum tubular network organization:P"], "name": "Lnp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040117": {"description": "GCSF/MGF", "go_ids": ["GO:0005125", "GO:0045639"], "go_terms": ["GO:0005125:cytokine activity:F", "GO:0045639:positive regulation of myeloid cell differentiation:P"], "name": "GCSF/MGF", "pathway_ids": ["R-GGA-9674555", "R-BTA-9705462", "R-HSA-449836", "R-MMU-9674555", "R-HSA-9705462", "R-SSC-449836", "R-BTA-449836", "R-SSC-9705462", "R-HSA-9674555", "R-BTA-9674555", "R-HSA-6783783", "R-GGA-449836", "R-GGA-9705462", "R-SSC-9674555", "R-MMU-9705462"], "pathways": ["R-GGA-9674555:r:Signaling by CSF3 (G-CSF)", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-449836:r:Other interleukin signaling", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-449836:r:Other interleukin signaling", "R-BTA-449836:r:Other interleukin signaling", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-BTA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-6783783:r:Interleukin-10 signaling", "R-GGA-449836:r:Other interleukin signaling", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling"], "type": "Family"}, "IPR040118": {"description": "Coiled-coil domain-containing protein 144A/B/C", "go_ids": [], "go_terms": [], "name": "C144A/B/C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040119": {"description": "Uncharacterized protein C10orf67-like", "go_ids": [], "go_terms": [], "name": "C10orf67-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040120": {"description": "Uncharacterized protein C19orf44-like", "go_ids": [], "go_terms": [], "name": "C19orf44-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040122": {"description": "Importin beta family", "go_ids": ["GO:0006606"], "go_terms": ["GO:0006606:protein import into nucleus:P"], "name": "Importin_beta", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-SPO-68616", "R-RNO-2995383", "R-DME-2995383", "R-SPO-2995383", "R-SCE-6798695", "R-HSA-1169408", "R-SCE-2995383", "R-RNO-1655829", "R-RNO-140342", "R-HSA-68616", "R-HSA-9828806", "R-RNO-68616", "R-HSA-192905", "R-MMU-909733", "R-MMU-1655829", "R-MMU-2995383", "R-MMU-5620924", "R-HSA-140342", "R-HSA-1655829", "R-HSA-9636249", "R-HSA-5620924", "R-HSA-168276", "R-HSA-168271", "R-DME-909733", "R-DME-6798695", "R-HSA-9918432", "R-SCE-450513", "R-BTA-450513", "R-HSA-2995383", "R-DME-68616", "R-MMU-140342", "R-HSA-9615933", "R-MMU-450513", "R-HSA-909733", "R-RNO-909733", "R-DME-1655829", "R-HSA-9692916", "R-HSA-450513", "R-MMU-6798695", "R-DME-140342", "R-MMU-68616", "R-HSA-180746", "R-DDI-450513", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SPO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-SCE-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-192905:r:vRNP Assembly", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-HSA-5620924:r:Intraflagellar transport", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-DME-909733:r:Interferon alpha/beta signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9918432:r:Maturation of DENV proteins", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-DME-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-180746:r:Nuclear import of Rev protein", "R-DDI-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-RNO-6798695:r:Neutrophil 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{"description": "BMERB domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "BMERB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040128": {"description": "Uncharacterized protein T25E4.2-like", "go_ids": [], "go_terms": [], "name": "T25E4.2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040129": {"description": "Protein lin-15B-like", "go_ids": ["GO:0040027"], "go_terms": ["GO:0040027:negative regulation of vulval development:P"], "name": "Lin-15B-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040131": {"description": "MnmG, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MnmG_N", "pathway_ids": ["R-HSA-6787450"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR040132": {"description": "TREX component Tex1/THOC3", "go_ids": ["GO:0006406"], "go_terms": ["GO:0006406:mRNA export from nucleus:P"], "name": "Tex1/THOC3", "pathway_ids": ["R-MMU-72187", "R-BTA-73856", "R-BTA-159236", "R-MMU-73856", "R-HSA-73856", "R-HSA-159236", "R-HSA-72187", "R-MMU-159236"], "pathways": ["R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR040133": {"description": "Synphilin-1", "go_ids": [], "go_terms": [], "name": "SNCAIP", "pathway_ids": ["R-HSA-977225"], "pathways": ["R-HSA-977225:r:Amyloid fiber formation"], "type": "Family"}, "IPR040134": {"description": "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4", "go_ids": [], "go_terms": [], "name": "PSMD12/CSN4", "pathway_ids": ["R-RNO-6781823", "R-MMU-450408", "R-HSA-174178", "R-HSA-9020702", "R-HSA-9604323", "R-RNO-9013422", "R-BTA-5689880", "R-MMU-8941858", "R-HSA-5689880", "R-HSA-8951664", "R-HSA-9010553", "R-BTA-9755511", "R-BTA-1234176", "R-HSA-75815", "R-MMU-174154", "R-MMU-69017", "R-MMU-9020702", "R-MMU-8948751", "R-MMU-69481", "R-DME-5696394", "R-BTA-350562", "R-SPO-5689880", "R-DDI-8856825", "R-MMU-5689880", "R-MMU-75815", "R-BTA-75815", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-BTA-69601", "R-MMU-5668541", "R-HSA-8854050", "R-MMU-5696394", "R-BTA-5607761", "R-HSA-450408", "R-CEL-5696394", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-BTA-68867", "R-HSA-1234176", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-DDI-174084", "R-MMU-68867", "R-MMU-9932298", "R-MMU-1234176", "R-RNO-5696394", "R-MMU-4641258", "R-DDI-4641258", "R-DDI-5696394", "R-RNO-8951664", "R-BTA-69017", "R-HSA-5696394", "R-HSA-180534", "R-HSA-1236974", "R-BTA-4641257", "R-MMU-5687128", "R-CEL-8856825", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-DDI-187577", "R-HSA-68949", "R-HSA-5610785", "R-BTA-1236978", "R-DDI-382556", "R-HSA-2467813", "R-MMU-187577", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-HSA-9824272", "R-BTA-4608870", "R-BTA-5676590", "R-DDI-174178", "R-DDI-9013422", "R-MMU-174178", "R-MMU-349425", "R-MMU-8939236", "R-BTA-2871837", "R-HSA-9907900", "R-MMU-6781823", "R-BTA-174154", "R-BTA-6781823", "R-DDI-5689603", "R-DDI-69601", "R-DDI-2467813", "R-BTA-174184", "R-MMU-9762114", "R-HSA-9762114", "R-DRE-6781823", "R-DDI-5689880", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-SSC-6781823", "R-HSA-5610780", "R-BTA-8939236", "R-BTA-5632684", "R-MMU-382556", "R-DDI-5687128", "R-BTA-187577", "R-BTA-9931269", "R-BTA-5696394", "R-DDI-9907900", "R-SCE-1236978", "R-MMU-1169091", "R-DME-9013422", "R-BTA-9929356", "R-MMU-5607761", "R-MMU-5676590", "R-BTA-9013422", "R-HSA-8939902", "R-MMU-174184", "R-MMU-8939902", "R-HSA-8856825", "R-BTA-9954709", "R-DRE-9013422", "R-HSA-8939236", "R-SPO-350562", "R-HSA-5358346", "R-CEL-8951664", "R-BTA-983168", "R-HSA-6798695", "R-DDI-8854050", "R-MMU-5632684", "R-HSA-9013422", "R-SPO-9907900", "R-BTA-5610785", "R-MMU-5607764", "R-BTA-202424", "R-MMU-2467813", "R-DME-6781823", "R-HSA-9932298", "R-DRE-8951664", "R-DME-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-BTA-6798695", "R-HSA-5676590", "R-DDI-1236978", "R-DDI-5632684", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-8951664", "R-BTA-9929491", "R-MMU-9013422", "R-HSA-4641257", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9929356", "R-SSC-9013422", "R-MMU-9929491", "R-SCE-5668541", "R-HSA-68867", "R-MMU-9907900", "R-HSA-69481", "R-BTA-174084", "R-BTA-450408", "R-DDI-5658442", "R-BTA-5687128", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DDI-6781823", "R-HSA-9755511", "R-HSA-4641258", "R-DRE-5696394", "R-SPO-5689603", "R-CEL-6781823", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-HSA-1169091", "R-HSA-4608870", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-SPO-6798695", "R-HSA-187577", "R-MMU-5610780", "R-DDI-9755511", "R-BTA-382556", "R-MMU-8856825", "R-HSA-349425", "R-BTA-8941858", "R-MMU-9755511", "R-SSC-8951664", "R-HSA-174184", "R-MMU-350562", "R-DDI-75815", "R-MMU-9954709", "R-MMU-69601", "R-HSA-2871837", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-SSC-8856825", "R-MMU-5658442", "R-MMU-5689603", "R-HSA-174084", "R-MMU-4608870", "R-HSA-5607764", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-DRE-8856825", "R-DME-8856825", "R-BTA-8948751", "R-RNO-8856825", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-SCE-9907900", "R-HSA-5668541", "R-BTA-5689603", "R-HSA-9929356", "R-BTA-8856825", "R-DDI-983168", "R-HSA-5687128", "R-DDI-349425", "R-HSA-69017", "R-BTA-9020702", "R-MMU-983168", "R-BTA-5607764", "R-DDI-450408", "R-MMU-1236978", "R-HSA-350562", "R-HSA-202424", "R-DDI-174154"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-5689880:r:Ub-specific processing proteases", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of 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"R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-8951664:r:Neddylation", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-8856825:r:Cargo 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"R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689603:r:UCH proteinases", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin"], "type": "Family"}, "IPR040138": {"description": "Mesoderm induction early response protein/metastasis-associated protein", "go_ids": [], "go_terms": [], "name": "MIER/MTA", "pathway_ids": ["R-MMU-73762", "R-RNO-8943724", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-RNO-73762", "R-MMU-8943724", "R-RNO-3214815", "R-HSA-6804758", "R-HSA-9844594", "R-RNO-3232118", "R-HSA-9845323", "R-HSA-8943724", "R-HSA-3232118", "R-MMU-3232118", "R-MMU-6804758", "R-HSA-9843940", "R-HSA-427389"], "pathways": ["R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-8943724:r:Regulation of PTEN gene 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"name": "ITM2", "pathway_ids": ["R-HSA-977225"], "pathways": ["R-HSA-977225:r:Amyloid fiber formation"], "type": "Family"}, "IPR040148": {"description": "Fragile X messenger ribonucleoprotein 1", "go_ids": ["GO:0006417", "GO:0003729"], "go_terms": ["GO:0006417:regulation of translation:P", "GO:0003729:mRNA binding:F"], "name": "FMR1", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Family"}, "IPR040150": {"description": "RNA polymerase II nuclear localization protein Iwr1", "go_ids": ["GO:0006606"], "go_terms": ["GO:0006606:protein import into nucleus:P"], "name": "Iwr1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040151": {"description": "Gfd2/YDR514C-like", "go_ids": [], "go_terms": [], "name": "Gfd2/YDR514C-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040152": {"description": "ATPase synthesis protein 25, mitochondrial", "go_ids": ["GO:0140053"], "go_terms": ["GO:0140053:mitochondrial 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"R-DDI-611105", "R-CEL-611105", "R-MMU-611105", "R-SPO-611105", "R-SCE-611105", "R-DME-611105"], "pathways": ["R-SSC-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-DDI-611105:r:Respiratory electron transport", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-DME-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR040159": {"description": "Suppressor of hairless-like", "go_ids": ["GO:0001228", "GO:0006357"], "go_terms": ["GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "CLS_fam", "pathway_ids": ["R-HSA-9013508", "R-DME-350054", "R-HSA-8941856", "R-HSA-210744", "R-MMU-2122947", "R-HSA-2894862", "R-HSA-9824272", "R-BTA-8941856", "R-HSA-350054", "R-BTA-350054", "R-HSA-1912408", "R-HSA-9013695", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-2122947"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-DME-350054:r:Notch-HLH transcription pathway", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9824272:r:Somitogenesis", "R-BTA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-BTA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Family"}, "IPR040160": {"description": "Eukaryotic translation initiation factor 4E-binding protein Mextli", "go_ids": ["GO:0008190", "GO:0045727"], "go_terms": ["GO:0008190:eukaryotic initiation factor 4E binding:F", "GO:0045727:positive regulation of translation:P"], "name": "Mxt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040161": {"description": "F-box A protein FB224", "go_ids": [], "go_terms": [], "name": "FB224", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040162": {"description": "Microsomal glutathione S-transferase 1-like", "go_ids": [], "go_terms": [], "name": "MGST1-like", "pathway_ids": ["PWY-6842", "PWY-7533", "PWY-7112", 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"R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-GGA-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-6785631:r:ERBB2 Regulates Cell Motility", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-GGA-1250196:r:SHC1 events in ERBB2 signaling", "R-GGA-1257604:r:PIP3 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"R-MMU-8980692", "R-MMU-193648", "R-RNO-8980692", "R-RNO-9696264", "R-HSA-416482", "R-MMU-9696264", "R-MMU-9696273", "R-RNO-9696273", "R-RNO-193648", "R-HSA-9696273", "R-HSA-9696264", "R-DDI-193648"], "pathways": ["R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-DDI-193648:r:NRAGE signals death through JNK"], "type": "Family"}, "IPR040182": {"description": "Autophagy-related protein 13", "go_ids": ["GO:0000045"], "go_terms": ["GO:0000045:autophagosome assembly:P"], "name": "ATG13", "pathway_ids": ["R-DRE-1632852", "R-DME-1632852", "R-SCE-1632852", "R-CEL-1632852", "R-MMU-1632852", "R-SPO-1632852", "R-BTA-1632852", "R-HSA-1632852"], "pathways": ["R-DRE-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-SCE-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-BTA-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy"], "type": "Family"}, "IPR040183": {"description": "THUMP domain-containing protein 1-like", "go_ids": ["GO:0003723", "GO:0006400"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0006400:tRNA modification:P"], "name": "THUMPD1-like", "pathway_ids": ["R-HSA-6790901"], "pathways": ["R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR040184": {"description": "Minichromosome maintenance protein 10", "go_ids": ["GO:0003697", "GO:0006270", "GO:0003690"], "go_terms": ["GO:0003697:single-stranded DNA binding:F", "GO:0006270:DNA replication initiation:P", "GO:0003690:double-stranded DNA binding:F"], "name": "Mcm10", "pathway_ids": ["R-DME-68962", "R-SPO-176187", "R-DRE-68962", "R-MMU-68962", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-HSA-176187", "R-SCE-176187", "R-SCE-68962", "R-DME-176187"], "pathways": ["R-DME-68962:r:Activation of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-DRE-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Family"}, "IPR040185": {"description": "Far11/STRP", "go_ids": [], "go_terms": [], "name": "Far11/STRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040186": {"description": "Citramalyl-CoA lyase", "go_ids": [], "go_terms": [], "name": "Citramalyl-CoA_lyase", "pathway_ids": ["PWY-5826", "PWY-7649", "PWY-7118", "PWY-7294", "PWY-7275", "PWY-7854", "PWY-6728", "PWY-5749", "PWY-8305", "PWY-7295", "PWY-7784", "PWY-8216", "PWY-5744"], "pathways": ["PWY-5826:t:hypoglycin biosynthesis", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7118:t:chitin deacetylation", "PWY-7294:t:D-xylose degradation IV", "PWY-7275:t:L-homophenylalanine biosynthesis", "PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-6728:t:methylaspartate cycle", "PWY-5749:t:itaconate degradation", "PWY-8305:t:methoxylated aromatic compound degradation II", "PWY-7295:t:L-arabinose degradation IV", "PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)", "PWY-8216:t:strychnine biosynthesis", "PWY-5744:t:glyoxylate assimilation"], "type": "Family"}, "IPR040187": {"description": "OCIA domain-containing protein 1/2", "go_ids": [], "go_terms": [], "name": "OCAD1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040190": {"description": "N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein", "go_ids": [], "go_terms": [], "name": "MURQ/GCKR", "pathway_ids": ["R-HSA-5619107", "R-HSA-170822", "R-MMU-170822", "R-RNO-170822"], "pathways": ["R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein"], "type": "Family"}, "IPR040191": {"description": "U3 small nucleolar RNA-associated protein 10", "go_ids": [], "go_terms": [], "name": "UTP10", "pathway_ids": ["R-DME-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR040192": {"description": "CUE domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "CUEDC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040193": {"description": "EF-hand domain-containing protein EFHC1/EFHC2/EFHB", "go_ids": [], "go_terms": [], "name": "EFHC1/EFHC2/EFHB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040194": {"description": "Cwf19-like protein", "go_ids": [], "go_terms": [], "name": "Cwf19-like", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR040198": {"description": "Fido domain-containing protein", "go_ids": [], "go_terms": [], "name": "Fido_containing", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I"], "type": "Family"}, "IPR040200": {"description": "FAS1 domain-containing protein Mug57-like", "go_ids": [], "go_terms": [], "name": "Mug57-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040201": {"description": "Protein Mrg3-like", "go_ids": [], "go_terms": [], "name": "Mrg3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040202": {"description": "Nucleus export protein Brl1/Brr6", "go_ids": ["GO:0005635", "GO:0006998"], "go_terms": ["GO:0005635:nuclear envelope:C", "GO:0006998:nuclear envelope organization:P"], "name": "Brl1/Brr6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040203": {"description": "DNA replication regulator Sld2", "go_ids": ["GO:0006270"], "go_terms": ["GO:0006270:DNA replication initiation:P"], "name": "Sld2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040204": {"description": "E3 ubiquitin-protein ligase UBR7", "go_ids": ["GO:0061630", "GO:0008270"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0008270:zinc ion binding:F"], "name": "UBR7", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR040205": {"description": "HIN-200 family", "go_ids": ["GO:0002218", "GO:0035458"], "go_terms": ["GO:0002218:activation of innate immune response:P", "GO:0035458:cellular response to interferon-beta:P"], "name": "HIN-200", "pathway_ids": ["R-HSA-1834949", "R-MMU-6798695", "R-HSA-6798695", "R-HSA-3270619", "R-HSA-844615", "R-MMU-844615", "R-MMU-1834949", "R-HSA-1834941"], "pathways": ["R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-844615:r:The AIM2 inflammasome", "R-MMU-844615:r:The AIM2 inflammasome", "R-MMU-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-1834941:r:STING mediated induction of host immune responses"], "type": "Family"}, "IPR040206": {"description": "Protein Zds1/2", "go_ids": [], "go_terms": [], "name": "Zds1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040210": {"description": "Cep85/Cep85L", "go_ids": [], "go_terms": [], "name": "Cep85/Cep85L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040211": {"description": "Small EDRK-rich factor 1/2-like", "go_ids": [], "go_terms": [], "name": "SERF1/2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040213": {"description": "GIR2-like", "go_ids": [], "go_terms": [], "name": "GIR2-like", "pathway_ids": ["R-MMU-9629569", "R-HSA-9629569"], "pathways": ["R-MMU-9629569:r:Protein hydroxylation", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Family"}, "IPR040214": {"description": "Uncharacterized bromodomain-containing protein 10", "go_ids": [], "go_terms": [], "name": "BRD10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040216": {"description": "Cytotoxic T-lymphocyte protein 4/CD28", "go_ids": ["GO:0042129"], "go_terms": ["GO:0042129:regulation of T cell proliferation:P"], "name": "CTLA4/CD28", "pathway_ids": ["R-MMU-389359", "R-MMU-6811558", "R-RNO-1257604", "R-HSA-2219530", "R-MMU-1257604", "R-HSA-164939", "R-RNO-389356", "R-MMU-389513", "R-HSA-6811558", "R-MMU-389356", "R-MMU-389357", "R-HSA-389356", "R-HSA-8877330", "R-RNO-6811558", "R-RNO-389359", "R-HSA-389359", "R-HSA-389357", "R-HSA-1257604", "R-HSA-389513", "R-RNO-389357"], "pathways": ["R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-164939:r:Nef mediated downregulation of CD28 cell surface expression", "R-RNO-389356:r:Co-stimulation by CD28", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-389356:r:Co-stimulation by CD28", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-389359:r:CD28 dependent Vav1 pathway", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling"], "type": "Family"}, "IPR040217": {"description": "ACT domain-containing protein ACR1-12", "go_ids": [], "go_terms": [], "name": "ACR1-12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040218": {"description": "Probable RNA polymerase II nuclear localization protein SLC7A6OS", "go_ids": [], "go_terms": [], "name": "SLC7A6OS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040219": {"description": "Uncharacterized protein KIAA1143-like", "go_ids": [], "go_terms": [], "name": "KIAA1143-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040220": {"description": "Protein down-regulated in DIF1 11", "go_ids": [], "go_terms": [], "name": "DD11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040221": {"description": "CDCA7/CDA7L", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "CDCA7/CDA7L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040222": {"description": "ALOG family", "go_ids": [], "go_terms": [], "name": "ALOG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040223": {"description": "PAR basic leucine zipper protein", "go_ids": ["GO:0003700", "GO:0006357"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "PAR_bZIP", "pathway_ids": ["R-HSA-9931510"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes"], "type": "Family"}, "IPR040224": {"description": "RAD52 motif-containing protein 1", "go_ids": [], "go_terms": [], "name": "RDM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040225": {"description": "Protein gravitropic in the light 1-like", "go_ids": ["GO:0009639", "GO:0009959"], "go_terms": ["GO:0009639:response to red or far red light:P", "GO:0009959:negative gravitropism:P"], "name": "GIL1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040226": {"description": "THH1/TOM1/TOM3", "go_ids": [], "go_terms": [], "name": "THH1/TOM1/TOM3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040227": {"description": "Nibrin-related", "go_ids": ["GO:0007095", "GO:0006302", "GO:0030870"], "go_terms": ["GO:0007095:mitotic G2 DNA damage checkpoint signaling:P", "GO:0006302:double-strand break repair:P", "GO:0030870:Mre11 complex:C"], "name": "Nibrin-rel", "pathway_ids": ["R-HSA-5693616", "R-RNO-5693565", "R-GGA-351433", "R-RNO-5685939", "R-MMU-6804756", "R-HSA-5693565", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-DRE-5693568", "R-DRE-5693571", "R-HSA-9709570", "R-HSA-5693607", "R-MMU-5693568", "R-SPO-5685939", "R-DRE-5693579", "R-DRE-6804756", "R-GGA-217106", "R-RNO-5693579", "R-HSA-69473", "R-MMU-2559586", "R-RNO-5693607", "R-DRE-5685942", "R-RNO-5693571", "R-RNO-69473", "R-DRE-5693548", "R-HSA-6804756", "R-HSA-9704331", "R-DRE-69473", "R-RNO-5693568", "R-DRE-5693616", "R-DRE-5693565", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-HSA-2559586", "R-MMU-5693571", "R-DRE-5693607", "R-HSA-5685942", "R-HSA-9704646", "R-DRE-5685939", "R-RNO-5693548", "R-MMU-5693565", "R-DRE-2559586", "R-GGA-351444", "R-RNO-5685938", "R-HSA-912446", "R-MMU-5685939", "R-RNO-6804756", "R-GGA-351442", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-RNO-2559586", "R-MMU-5693548", "R-HSA-9709603", "R-MMU-5685942", "R-SPO-5693565", "R-HSA-5685939", "R-RNO-5685942", "R-HSA-5693571", "R-SPO-2559586", "R-SPO-5693548", "R-HSA-5693579", "R-DRE-5685938"], "pathways": ["R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Family"}, "IPR040229": {"description": "Uncharacterized membrane protein At3g27390-like", "go_ids": [], "go_terms": [], "name": "At3g27390-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040230": {"description": "Protease TIKI1/2-like", "go_ids": ["GO:0004175", "GO:0030178"], "go_terms": ["GO:0004175:endopeptidase activity:F", "GO:0030178:negative regulation of Wnt signaling pathway:P"], "name": "TIKI1/2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040232": {"description": "Protein Kreg-1", "go_ids": ["GO:0097501"], "go_terms": ["GO:0097501:stress response to metal ion:P"], "name": "Kreg-1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040233": {"description": "CCD97-like, C-terminal", "go_ids": [], "go_terms": [], "name": "CCD97-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040234": {"description": "Glutaminyl-peptide cyclotransferase-like", "go_ids": [], "go_terms": [], "name": "QC/QCL", "pathway_ids": ["PWY-7942", "R-SCE-6798695", "R-HSA-6798695", "R-DDI-6798695", "R-MMU-6798695", "R-DME-6798695"], "pathways": ["PWY-7942:t:5-oxo-L-proline metabolism", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR040235": {"description": "Nicolin-1", "go_ids": [], "go_terms": [], "name": "Nicolin-1", "pathway_ids": ["R-HSA-8955332"], "pathways": ["R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Family"}, "IPR040236": {"description": "Transmembrane protein 198", "go_ids": [], "go_terms": [], "name": "TMEM198", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040238": {"description": "Helix-loop-helix protein TAL-like", "go_ids": ["GO:0000981", "GO:0006357"], "go_terms": ["GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "TAL-like", "pathway_ids": ["R-HSA-9616222", "R-HSA-9031628", "R-DRE-8939236", "R-HSA-9918481", "R-HSA-8939236", "R-MMU-8939236"], "pathways": ["R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9031628:r:NGF-stimulated transcription", "R-DRE-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "type": "Family"}, "IPR040239": {"description": "Beta-lactamase HcpB-like", "go_ids": [], "go_terms": [], "name": "HcpB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040240": {"description": "Transcription initiation factor TFIID subunit 1", "go_ids": ["GO:0016251", "GO:0005669", "GO:0004402", "GO:0006366", "GO:0017025"], "go_terms": ["GO:0016251:RNA polymerase II general transcription initiation factor activity:F", "GO:0005669:transcription factor TFIID complex:C", "GO:0004402:histone acetyltransferase activity:F", "GO:0006366:transcription by RNA polymerase II:P", "GO:0017025:TBP-class protein binding:F"], "name": "TAF1", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DME-76042", "R-DDI-73776", "R-MMU-6804756", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-DDI-76042", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-CEL-73776", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-DME-674695", "R-DDI-73779", "R-MMU-674695", "R-SCE-76042", "R-DME-6804756", "R-CEL-674695", "R-HSA-167161", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-76042", "R-HSA-674695", "R-DDI-75953", "R-SPO-73776", "R-CEL-76042", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA 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["GO:0003713", "GO:0006357"], "go_terms": ["GO:0003713:transcription coactivator activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "Steroid_recept_RNA_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040244": {"description": "Protein enhanced disease resistance 4-like", "go_ids": ["GO:1900150"], "go_terms": ["GO:1900150:regulation of defense response to fungus:P"], "name": "EDR4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040246": {"description": "UPF0547 protein C16orf87-like", "go_ids": [], "go_terms": [], "name": "C16orf87-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040247": {"description": "Protein of unknown function DUF5524", "go_ids": [], "go_terms": [], "name": "DUF5524", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040248": {"description": "Ribosome-binding protein 1", "go_ids": [], "go_terms": [], "name": "RRBP1", "pathway_ids": ["R-HSA-9725370", "R-HSA-9918487"], "pathways": ["R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication"], "type": "Family"}, "IPR040249": {"description": "Ricin B-like lectin EULS3-like", "go_ids": [], "go_terms": [], "name": "Ricin_B-like_lectin_EULS3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040250": {"description": "Nucleobindin", "go_ids": [], "go_terms": [], "name": "Nucleobindin", "pathway_ids": ["R-RNO-381426", "R-MMU-381426", "R-HSA-8957275", "R-DME-381426", "R-DME-8957275", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DME-381426:r:Regulation of 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"R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-6804756", "R-DDI-674695", "R-CEL-112382", "R-HSA-167152", "R-SCE-674695", "R-DDI-6796648", "R-HSA-75955", "R-DDI-6804756", "R-CEL-6804756", "R-SPO-6796648", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382", "R-SCE-6796648"], "pathways": ["R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", 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"R-HSA-110312", "R-HSA-6783310", "R-RNO-69473", "R-HSA-6804756", "R-SPO-110314", "R-HSA-5696395", "R-MMU-176187", "R-MMU-6782210", "R-MMU-5696397", "R-MMU-174411", "R-SCE-6782135", "R-HSA-110314", "R-SPO-5651801", "R-HSA-3371511", "R-MMU-174430", "R-RNO-68962", "R-RNO-3371453", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5655862", "R-HSA-5358606", "R-MMU-110312", "R-SPO-110312", "R-RNO-69166", "R-BTA-174430", "R-RNO-5685938", "R-HSA-912446", "R-DRE-174430", "R-HSA-68962", "R-HSA-6782210", "R-RNO-6804756", "R-HSA-5656169", "R-SCE-6782210", "R-SCE-176187", "R-HSA-5685938", "R-HSA-176187", "R-RNO-174411", "R-MMU-5696400", "R-MMU-5693607", "R-MMU-3371453", "R-MMU-5655862", "R-RNO-5358606", "R-SPO-5696397", "R-RNO-5358565", "R-RNO-6782135", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-HSA-69166", "R-RNO-110320", "R-SCE-68962", "R-HSA-174411", "R-MMU-6783310", "R-RNO-5685942", "R-MMU-5656121", "R-SPO-5696400", "R-SPO-110320", "R-SPO-6782210", "R-MMU-69166", "R-RNO-5696400", "R-HSA-5696400", "R-HSA-5358565", "R-SPO-68962", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-HSA-110320", "R-RNO-6783310"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-110312:r:Translesion synthesis by REV1", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110312:r:Translesion synthesis by REV1", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-3371511:r:HSF1 activation", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-RNO-6783310:r:Fanconi Anemia Pathway"], "type": "Family"}, "IPR040261": {"description": "Protein FAM240", "go_ids": [], "go_terms": [], "name": "FAM240", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040262": {"description": "Uncharacterized protein At4g38062-like", "go_ids": [], "go_terms": [], "name": "At4g38062-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040263": {"description": "PWWP domain-containing DNA repair factor 3A/3B/4", "go_ids": [], "go_terms": [], "name": "PWP3A_3B_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040264": {"description": "Uncharacterized protein T15H9.4-like", "go_ids": [], "go_terms": [], "name": "T15H9.4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040265": {"description": "Protein CHUP1/IPGA1-like", "go_ids": [], "go_terms": [], "name": "CHUP1/IPGA1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040266": {"description": "TMF-regulated nuclear protein 1", "go_ids": ["GO:0003677", "GO:0005634", "GO:0042127"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0005634:nucleus:C", "GO:0042127:regulation of cell population proliferation:P"], "name": "TRNP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040267": {"description": "F-box protein EID1-like", "go_ids": [], "go_terms": [], "name": "EID1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040268": {"description": "Armadillo-like helical domain-containing protein 2", "go_ids": [], "go_terms": [], "name": "ARMH2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040269": {"description": "VAN3-binding protein", "go_ids": [], "go_terms": [], "name": "VAB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040271": {"description": "Uncharacterized protein T19C3.2-like", "go_ids": [], "go_terms": [], "name": "T19C3.2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040273": {"description": "PAMP-induced secreted peptide 1", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "PIP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040274": {"description": "CLAVATA3/ESR (CLE)-related protein 27/43", "go_ids": [], "go_terms": [], "name": "CLE27/CLE43", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040275": {"description": "F-box domain containing protein At5g39450-like", "go_ids": [], "go_terms": [], "name": "At5g39450-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040276": {"description": "Uncharacterized protein At4g26450-like", "go_ids": [], "go_terms": [], "name": "At4g26450-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040277": {"description": "Uncharacterized protein Os04g0629400-like", "go_ids": [], "go_terms": [], "name": "Os04g0629400-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040278": {"description": "UPF0426 protein", "go_ids": [], "go_terms": [], "name": "UPF0426", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040280": {"description": "Protein FAM163B", "go_ids": [], "go_terms": [], "name": "FAM163B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040281": {"description": "Protein FAM163A", "go_ids": [], "go_terms": [], "name": "FAM163A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040282": {"description": "Abnormal cell migration protein 18-like", "go_ids": [], "go_terms": [], "name": "Mig-18-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040283": {"description": "Transmembrane DDB_G0292058-like", "go_ids": [], "go_terms": [], "name": "DDB_G0292058-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040285": {"description": "Prolyl-tRNA editing protein ProX/PRXD1", "go_ids": [], "go_terms": [], "name": "ProX/PRXD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040286": {"description": "CRM domain-containing protein At3g25440-like", "go_ids": [], "go_terms": [], "name": "At3g25440-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040287": {"description": "Repulsive guidance molecule", "go_ids": [], "go_terms": [], "name": "RGM", "pathway_ids": ["R-HSA-373752"], "pathways": ["R-HSA-373752:r:Netrin-1 signaling"], "type": "Family"}, "IPR040288": {"description": "PX domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "PXDC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040289": {"description": "Microtubule binding protein 2C", "go_ids": ["GO:0010497", "GO:0008017"], "go_terms": ["GO:0010497:plasmodesmata-mediated intercellular transport:P", "GO:0008017:microtubule binding:F"], "name": "MBP2C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040290": {"description": "Protein E6-like", "go_ids": [], "go_terms": [], "name": "Prot_E6-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040291": {"description": "Uncharacterized transmembrane protein DDB_G0287341-like", "go_ids": [], "go_terms": [], "name": "DDB_G0287341-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040292": {"description": "Uncharacterized protein C2orf78-like", "go_ids": [], "go_terms": [], "name": "C2orf78-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040294": {"description": "Nodulin-related protein 1/2", "go_ids": ["GO:0009408", "GO:0010115"], "go_terms": ["GO:0009408:response to heat:P", "GO:0010115:regulation of abscisic acid biosynthetic process:P"], "name": "Nodulin-rel_1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040296": {"description": "Photosystem II 5kDa protein, chloroplastic", "go_ids": [], "go_terms": [], "name": "PSBT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040297": {"description": "Multivesicular body subunit 12B", "go_ids": [], "go_terms": [], "name": "MVB12B", "pathway_ids": ["R-HSA-9610379", "R-HSA-917729", "R-HSA-174490", "R-HSA-162588", "R-HSA-9615710", "R-MMU-917729"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-9615710:r:Late endosomal microautophagy", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Family"}, "IPR040299": {"description": "Protein FERTILITY RESTORER RF2-like", "go_ids": [], "go_terms": [], "name": "RF2K-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040300": {"description": "Uncharacterized protein At3g49055-like", "go_ids": [], "go_terms": [], "name": "At3g49055-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040301": {"description": "Secretoglobin 3A", "go_ids": ["GO:0005576"], "go_terms": ["GO:0005576:extracellular region:C"], "name": "Secretoglobin_3A", "pathway_ids": ["R-HSA-3000480"], "pathways": ["R-HSA-3000480:r:Scavenging by Class A Receptors"], "type": "Family"}, "IPR040304": {"description": "ATG8-interacting protein 1/2", "go_ids": [], "go_terms": [], "name": "ATG8-IP-1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040305": {"description": "At1g75730-like", "go_ids": [], "go_terms": [], "name": "At1g75730-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040306": {"description": "Os02g0753200-like", "go_ids": [], "go_terms": [], "name": "Os02g0753200-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040307": {"description": "Large ribosomal subunit protein cL37", "go_ids": [], "go_terms": [], "name": "PSRP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040308": {"description": "HUWE1-associated protein modifying stress responses", "go_ids": [], "go_terms": [], "name": "HAPR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040309": {"description": "H/ACA ribonucleoprotein complex non-core subunit Naf1", "go_ids": ["GO:0003723", "GO:0000493", "GO:0042254", "GO:0005732"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0000493:box H/ACA snoRNP assembly:P", "GO:0042254:ribosome biogenesis:P", "GO:0005732:sno(s)RNA-containing ribonucleoprotein complex:C"], "name": "Naf1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040310": {"description": "DDB_G0292248", "go_ids": [], "go_terms": [], "name": "DDB_G0292248", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040311": {"description": "Coiled-coil domain-containing protein 3", "go_ids": [], "go_terms": [], "name": "CCDC3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040312": {"description": "FLYWCH-type zinc finger-containing protein 1/2", "go_ids": [], "go_terms": [], "name": "FWCH1/FWCH2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040313": {"description": "Keratin-associated protein 6", "go_ids": ["GO:0031424"], "go_terms": ["GO:0031424:keratinization:P"], "name": "KAP6", "pathway_ids": ["R-MMU-6805567", "R-HSA-6805567"], "pathways": ["R-MMU-6805567:r:Keratinization", "R-HSA-6805567:r:Keratinization"], "type": "Family"}, "IPR040314": {"description": "Protein DOP1", "go_ids": ["GO:0006895"], "go_terms": ["GO:0006895:Golgi to endosome transport:P"], "name": "DOP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040315": {"description": "WD repeat-containing protein WDR46/Utp7", "go_ids": [], "go_terms": [], "name": "WDR46/Utp7", "pathway_ids": ["R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-CFA-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-SPO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR040316": {"description": "Integrator complex subunit 5", "go_ids": ["GO:0032039"], "go_terms": ["GO:0032039:integrator complex:C"], "name": "INTS5", "pathway_ids": ["R-MMU-6807505", "R-DME-6807505", "R-HSA-6807505", "R-DDI-6807505"], "pathways": ["R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR040319": {"description": "LSD1-like", "go_ids": [], "go_terms": [], "name": "LSD1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040320": {"description": "Uncharacterized protein At4g37920-like", "go_ids": [], "go_terms": [], "name": "At4g37920-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040321": {"description": "Coiled-coil domain-containing protein SCD2-like", "go_ids": ["GO:0000911"], "go_terms": ["GO:0000911:cytokinesis by cell plate formation:P"], "name": "SCD2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040322": {"description": "RNA-binding protein RO60", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "TROVE2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040323": {"description": "EARP and GARP complex-interacting protein 1", "go_ids": [], "go_terms": [], "name": "EIPR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040324": {"description": "WD repeat-containing protein WDR44/Dgr2", "go_ids": [], "go_terms": [], "name": "WDR44/Dgr2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040325": {"description": "RIMS-binding protein 1/2/3", "go_ids": [], "go_terms": [], "name": "RIMBP1/2/3", "pathway_ids": ["R-MMU-196108", "R-HSA-181429", "R-HSA-181430", "R-HSA-196108", "R-RNO-212676", "R-MMU-212676", "R-RNO-264642", "R-RNO-181430", "R-RNO-210500", "R-MMU-181430", "R-MMU-210500", "R-HSA-264642", "R-MMU-181429", "R-RNO-181429", "R-HSA-212676", "R-HSA-210500", "R-RNO-196108", "R-MMU-264642"], "pathways": ["R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle"], "type": "Family"}, "IPR040326": {"description": "HAP2/GCS1", "go_ids": [], "go_terms": [], "name": "HAP2/GCS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040327": {"description": "TLC domain-containing protein At5g14285-like", "go_ids": [], "go_terms": [], "name": "At5g14285-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040328": {"description": "Uncharacterized protein DDB_G0279899-like", "go_ids": [], "go_terms": [], "name": "DDB_G0279899-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040329": {"description": "Chemokine-like protein TAFA-5", "go_ids": [], "go_terms": [], "name": "TAFA-5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040330": {"description": "LYR motif-containing protein 1", "go_ids": [], "go_terms": [], "name": "LYRM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040335": {"description": "Multivesicular body subunit 12A", "go_ids": ["GO:0000813"], "go_terms": ["GO:0000813:ESCRT I complex:C"], "name": "MVB12A", "pathway_ids": ["R-RNO-917729", "R-HSA-9610379", "R-HSA-917729", "R-DRE-917729", "R-MMU-917729", "R-HSA-174490", "R-HSA-9615710", "R-BTA-917729", "R-HSA-162588"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-9615710:r:Late endosomal microautophagy", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion"], "type": "Family"}, "IPR040336": {"description": "Uncharacterized GPI-anchored protein At1g61900-lke", "go_ids": [], "go_terms": [], "name": "At1g61900-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040338": {"description": "Putative F-box protein At1g67623-like", "go_ids": [], "go_terms": [], "name": "At1g67623-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040339": {"description": "Protein SHOU4/SHOU4-like", "go_ids": [], "go_terms": [], "name": "SHOU4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040340": {"description": "Chloroplast enhancing stress tolerance protein", "go_ids": ["GO:0009535", "GO:0048564", "GO:0080183"], "go_terms": ["GO:0009535:chloroplast thylakoid membrane:C", "GO:0048564:photosystem I assembly:P", "GO:0080183:response to photooxidative stress:P"], "name": "CEST/Y3IP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040341": {"description": "G patch domain-containing protein 3", "go_ids": ["GO:0039536", "GO:0032480"], "go_terms": ["GO:0039536:negative regulation of RIG-I signaling pathway:P", "GO:0032480:negative regulation of type I interferon production:P"], "name": "GPATCH3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040342": {"description": "Dynein axonemal assembly factor 9 DNAAF9", "go_ids": [], "go_terms": [], "name": "DNAAF9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040343": {"description": "RNA 5'-triphosphatase Cet1/Ctl1", "go_ids": ["GO:0004651"], "go_terms": ["GO:0004651:polynucleotide 5'-phosphatase activity:F"], "name": "Cet1/Ctl1", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Family"}, "IPR040344": {"description": "Uncharacterized protein At3g17950-like", "go_ids": [], "go_terms": [], "name": "At3g17950-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040345": {"description": "Mug56/Spo71", "go_ids": ["GO:0032120"], "go_terms": ["GO:0032120:ascospore-type prospore membrane formation:P"], "name": "Mug56/Spo71", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040346": {"description": "GEX1/Brambleberry", "go_ids": [], "go_terms": [], "name": "GEX1/Brambleberry", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040347": {"description": "YAP1-binding protein 1/2", "go_ids": ["GO:0034599"], "go_terms": ["GO:0034599:cellular response to oxidative stress:P"], "name": "YBP1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040348": {"description": "Protein POLAR-like", "go_ids": ["GO:0008356"], "go_terms": ["GO:0008356:asymmetric cell division:P"], "name": "POLAR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040349": {"description": "Monopolin complex subunit Csm1/Pcs1", "go_ids": ["GO:0033551"], "go_terms": ["GO:0033551:monopolin complex:C"], "name": "Csm1/Pcs1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040350": {"description": "Transmembrane protein 272", "go_ids": [], "go_terms": [], "name": "TMEM272", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040351": {"description": "Guanine nucleotide exchange factor RAB3IL/RAB3IP/Sec2", "go_ids": ["GO:0005085"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "RAB3IL/RAB3IP/Sec2", "pathway_ids": ["R-SPO-5620912", "R-MMU-5620916", "R-SCE-5620912", "R-RNO-5620916", "R-RNO-5620922", "R-RNO-8876198", "R-HSA-8876198", "R-RNO-5620912", "R-SCE-8876198", "R-HSA-5620916", "R-MMU-8876198", "R-BTA-8876198", "R-MMU-5620922", "R-MMU-5620912", "R-HSA-5620912", "R-SPO-8876198", "R-HSA-5620922"], "pathways": ["R-SPO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Family"}, "IPR040352": {"description": "Transmembrane and ubiquitin-like domain-containing protein 1/2", "go_ids": ["GO:0036503"], "go_terms": ["GO:0036503:ERAD pathway:P"], "name": "TMUB1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040353": {"description": "FLC EXPRESSOR/FLX-like", "go_ids": [], "go_terms": [], "name": "FLX/FLX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040354": {"description": "Tectonic-1-3", "go_ids": [], "go_terms": [], "name": "TCTN1-3", "pathway_ids": ["R-RNO-5620912", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR040355": {"description": "Protein FAM220A", "go_ids": [], "go_terms": [], "name": "FAM220A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040356": {"description": "SPEAR family", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "SPEAR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040357": {"description": "Vma22/CCDC115", "go_ids": ["GO:0070072"], "go_terms": ["GO:0070072:vacuolar proton-transporting V-type ATPase complex assembly:P"], "name": "Vma22/CCDC115", "pathway_ids": ["R-BTA-8980692", "R-DRE-8980692", "R-HSA-8980692", "R-MMU-8980692"], "pathways": ["R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Family"}, "IPR040358": {"description": "Uncharacterized protein At4g22758-like", "go_ids": [], "go_terms": [], "name": "At4g22758-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040359": {"description": "Protein glutamine dumper", "go_ids": ["GO:0080143"], "go_terms": ["GO:0080143:regulation of amino acid export:P"], "name": "GDU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040361": {"description": "Tapetum determinant 1", "go_ids": [], "go_terms": [], "name": "TPD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040362": {"description": "RAB11-binding protein RELCH", "go_ids": ["GO:0005802", "GO:0032367"], "go_terms": ["GO:0005802:trans-Golgi network:C", "GO:0032367:intracellular cholesterol transport:P"], "name": "RELCH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040363": {"description": "Homeobox-containing protein 1", "go_ids": ["GO:0003691"], "go_terms": ["GO:0003691:double-stranded telomeric DNA binding:F"], "name": "HMBOX1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040364": {"description": "Tetratricopeptide repeat protein 21A/21B", "go_ids": [], "go_terms": [], "name": "TTC21A/TTC21B", "pathway_ids": ["R-HSA-5610787", "R-HSA-5620924", "R-CEL-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-CEL-5610787"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state"], "type": "Family"}, "IPR040365": {"description": "EF-hand domain-containing protein D1/2", "go_ids": ["GO:0005509"], "go_terms": ["GO:0005509:calcium ion binding:F"], "name": "EFHD1/2", "pathway_ids": ["R-HSA-9013405"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle"], "type": "Family"}, "IPR040366": {"description": "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14", "go_ids": ["GO:0008143", "GO:0043488"], "go_terms": ["GO:0008143:poly(A) binding:F", "GO:0043488:regulation of mRNA stability:P"], "name": "Nab2/ZC3H14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040369": {"description": "LisH domain-containing protein ARMC9", "go_ids": ["GO:0060271", "GO:0036064"], "go_terms": ["GO:0060271:cilium assembly:P", "GO:0036064:ciliary basal body:C"], "name": "ARMC9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040370": {"description": "Coiled-coil domain-containing protein 74A/74B/92", "go_ids": [], "go_terms": [], "name": "CCDC74A/CCDC74B/CCDC92", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040371": {"description": "Regulator of MON1-CCZ1 complex", "go_ids": ["GO:0010506", "GO:0035658"], "go_terms": ["GO:0010506:regulation of autophagy:P", "GO:0035658:Mon1-Ccz1 complex:C"], "name": "RMC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040372": {"description": "YaeB-like", "go_ids": [], "go_terms": [], "name": "YaeB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040373": {"description": "Transcription factor castor", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "CASZ1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040374": {"description": "Protein BIC", "go_ids": ["GO:0009785"], "go_terms": ["GO:0009785:blue light signaling pathway:P"], "name": "BIC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040375": {"description": "Microprocessor complex subunit DGCR8", "go_ids": ["GO:0003723", "GO:0020037", "GO:0070877", "GO:0031053", "GO:0042802"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0020037:heme binding:F", "GO:0070877:microprocessor complex:C", "GO:0031053:primary miRNA processing:P", "GO:0042802:identical protein binding:F"], "name": "DGCR8", "pathway_ids": ["R-HSA-203927", "R-HSA-8986944"], "pathways": ["R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-8986944:r:Transcriptional Regulation by MECP2"], "type": "Family"}, "IPR040376": {"description": "At4g28100-like", "go_ids": [], "go_terms": [], "name": "At4g28100-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040377": {"description": "Thylakoid membrane protein Ssl2009-like", "go_ids": [], "go_terms": [], "name": "Ssl2009-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040378": {"description": "Protein BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE", "go_ids": ["GO:0009786"], "go_terms": ["GO:0009786:regulation of asymmetric cell division:P"], "name": "BASL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040379": {"description": "WD repeat-containing protein 19/dyf-2", "go_ids": ["GO:0035721"], "go_terms": ["GO:0035721:intraciliary retrograde transport:P"], "name": "WDR19/dyf-2", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-CEL-5620924", "R-CEL-5610787", "R-HSA-5610787", "R-MMU-5610787"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state"], "type": "Family"}, "IPR040381": {"description": "Uncharacterized protein At4g14450, chloroplastic", "go_ids": [], "go_terms": [], "name": "At4g14450", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040382": {"description": "Nucleolar protein 10/Enp2", "go_ids": [], "go_terms": [], "name": "NOL10/Enp2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040383": {"description": "E3 ubiquitin-protein ligase HAKAI/CBLL2", "go_ids": ["GO:0016567", "GO:0061630"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0061630:ubiquitin protein ligase activity:F"], "name": "HAKAI/CBLL2", "pathway_ids": ["PWY-7511", "R-DME-983168", "R-HSA-9766229", "R-HSA-983168", "R-MMU-9766229", "R-MMU-983168", "R-HSA-8876493"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9766229:r:Degradation of CDH1", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells"], "type": "Family"}, "IPR040384": {"description": "Orcokinin peptides type A/B", "go_ids": ["GO:0005184"], "go_terms": ["GO:0005184:neuropeptide hormone activity:F"], "name": "ORCKA/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040385": {"description": "Rab-like protein 6", "go_ids": ["GO:0005525"], "go_terms": ["GO:0005525:GTP binding:F"], "name": "RABL6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040386": {"description": "Transcriptional repressor p66", "go_ids": ["GO:0000122"], "go_terms": ["GO:0000122:negative regulation of transcription by RNA polymerase II:P"], "name": "P66", "pathway_ids": ["R-MMU-73762", "R-MMU-3214815", "R-HSA-3214815", "R-HSA-9679191", "R-HSA-73762", "R-MMU-8943724", "R-HSA-6804758", "R-CEL-8943724", "R-HSA-9844594", "R-HSA-9845323", "R-HSA-8943724", "R-MMU-6804758", "R-HSA-9843940", "R-HSA-427389"], "pathways": ["R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"], "type": "Family"}, "IPR040387": {"description": "RPM1-interacting protein 4/NOI4", "go_ids": [], "go_terms": [], "name": "RIN4/NOI4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040388": {"description": "CXXC-type zinc finger protein CXXC4/CXXC5", "go_ids": [], "go_terms": [], "name": "CXXC4/CXXC5", "pathway_ids": ["R-HSA-9018519", "R-HSA-5368598"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins"], "type": "Family"}, "IPR040389": {"description": "Cyclin-dependent protein kinase inhibitor SMR", "go_ids": ["GO:0032875"], "go_terms": ["GO:0032875:regulation of DNA endoreduplication:P"], "name": "SMR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040390": {"description": "TIFY/JAZ family", "go_ids": [], "go_terms": [], "name": "TIFY/JAZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040391": {"description": "BEN domain-containing protein 5", "go_ids": ["GO:0003677", "GO:0045892"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "BEND5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040393": {"description": "Three-prime repair exonuclease 1/2", "go_ids": ["GO:0008408"], "go_terms": ["GO:0008408:3'-5' exonuclease activity:F"], "name": "TREX1/2", "pathway_ids": ["R-HSA-3270619", "R-HSA-3248023"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-3248023:r:Regulation by TREX1"], "type": "Family"}, "IPR040394": {"description": "F-box only protein 25/32", "go_ids": [], "go_terms": [], "name": "FBX25/32", "pathway_ids": ["R-BTA-983168", "R-MMU-8951664", "R-BTA-8951664", "R-HSA-9615017", "R-SSC-983168", "R-RNO-8951664", "R-HSA-8951664", "R-RNO-983168", "R-MMU-983168", "R-SSC-8951664", "R-HSA-983168"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR040395": {"description": "Tetratricopeptide repeat protein 19", "go_ids": ["GO:0034551"], "go_terms": ["GO:0034551:mitochondrial respiratory chain complex III assembly:P"], "name": "TTC19", "pathway_ids": ["R-RNO-9865881", "R-DRE-9865881", "R-HSA-9865881", "R-DME-9865881", "R-MMU-9865881"], "pathways": ["R-RNO-9865881:r:Complex III assembly", "R-DRE-9865881:r:Complex III assembly", "R-HSA-9865881:r:Complex III assembly", "R-DME-9865881:r:Complex III assembly", "R-MMU-9865881:r:Complex III assembly"], "type": "Family"}, "IPR040396": {"description": "Polyadenylate-binding protein-interacting protein 2-like", "go_ids": ["GO:0045947", "GO:0000900"], "go_terms": ["GO:0045947:negative regulation of translational initiation:P", "GO:0000900:mRNA regulatory element binding translation repressor activity:F"], "name": "PAIP2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040397": {"description": "Suppressor of white apricot", "go_ids": [], "go_terms": [], "name": "SWAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040398": {"description": "CCR4-NOT transcription complex subunit 1", "go_ids": ["GO:0017148", "GO:0030015"], "go_terms": ["GO:0017148:negative regulation of translation:P", "GO:0030015:CCR4-NOT core complex:C"], "name": "Not1", "pathway_ids": ["R-XTR-429947", "R-MMU-6804115", "R-HSA-6804115", "R-XTR-6804115", "R-DRE-6804115", "R-HSA-429947", "R-MMU-429947", "R-HSA-9820841"], "pathways": ["R-XTR-429947:r:Deadenylation of mRNA", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Family"}, "IPR040399": {"description": "Transmembrane protein 35A/B", "go_ids": [], "go_terms": [], "name": "TMEM35A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040400": {"description": "BAG family molecular chaperone regulator 5/6/7/8", "go_ids": [], "go_terms": [], "name": "BAG5/6/7/8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040401": {"description": "Coiled-coil domain-containing protein 162", "go_ids": [], "go_terms": [], "name": "CCDC162", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040404": {"description": "Phylloplanin-like", "go_ids": [], "go_terms": [], "name": "Phylloplanin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040405": {"description": "Uncharacterized protein DDB_G0275255-like", "go_ids": [], "go_terms": [], "name": "DDB_G0275255-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040409": {"description": "Phytochelatin synthase", "go_ids": ["GO:0046872", "GO:0016756", "GO:0046938"], "go_terms": ["GO:0046872:metal ion binding:F", "GO:0016756:glutathione gamma-glutamylcysteinyltransferase activity:F", "GO:0046938:phytochelatin biosynthetic process:P"], "name": "PCS-like", "pathway_ids": ["PWY-6745"], "pathways": ["PWY-6745:t:phytochelatins biosynthesis"], "type": "Family"}, "IPR040410": {"description": "UPF0658 Golgi apparatus membrane protein", "go_ids": [], "go_terms": [], "name": "UPF0658_Golgi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040411": {"description": "Uncharacterized protein At5g23160-like", "go_ids": [], "go_terms": [], "name": "At5g23160-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040412": {"description": "Uncharacterized protein At1g65710-like", "go_ids": [], "go_terms": [], "name": "At1g65710-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040414": {"description": "PAM2-containing protein CID1/CID2", "go_ids": [], "go_terms": [], "name": "CID1/CID2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040415": {"description": "SET domain-containing protein 9", "go_ids": [], "go_terms": [], "name": "SETD9", "pathway_ids": ["R-HSA-6804760"], "pathways": ["R-HSA-6804760:r:Regulation of TP53 Activity through Methylation"], "type": "Family"}, "IPR040416": {"description": "Transmembrane protein 181", "go_ids": ["GO:0015643"], "go_terms": ["GO:0015643:toxic substance binding:F"], "name": "TMEM181", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040417": {"description": "Glycine-rich cell wall structural protein 1/2", "go_ids": [], "go_terms": [], "name": "GRP1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040418": {"description": "Protein crowded nuclei", "go_ids": ["GO:0006997", "GO:0005634"], "go_terms": ["GO:0006997:nucleus organization:P", "GO:0005634:nucleus:C"], "name": "CRWN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040419": {"description": "DUF5568 family", "go_ids": [], "go_terms": [], "name": "DUF5568", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040420": {"description": "Uncharacterized protein At1g76660-like", "go_ids": [], "go_terms": [], "name": "At1g76660-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040423": {"description": "Phosphoethanolamine transferase", "go_ids": ["GO:0016772"], "go_terms": ["GO:0016772:transferase activity, transferring phosphorus-containing groups:F"], "name": "PEA_transferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040424": {"description": "SMN complex subunit Smn1", "go_ids": [], "go_terms": [], "name": "Smn1", "pathway_ids": ["R-BTA-191859", "R-RNO-191859", "R-HSA-191859", "R-HSA-9754678", "R-MMU-191859", "R-DRE-191859"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-RNO-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-MMU-191859:r:snRNP Assembly", "R-DRE-191859:r:snRNP Assembly"], "type": "Family"}, "IPR040425": {"description": "Uncharacterized protein C20orf141-like", "go_ids": [], "go_terms": [], "name": "C20orf141-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040426": {"description": "Uncharacterized protein C05B5.4-like", "go_ids": [], "go_terms": [], "name": "C05B5.4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040427": {"description": "Fl(2)d-associated complex component", "go_ids": ["GO:0016556", "GO:0036396"], "go_terms": ["GO:0016556:mRNA modification:P", "GO:0036396:RNA N6-methyladenosine methyltransferase complex:C"], "name": "Flacc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040429": {"description": "Uncharacterised protein C11orf97-like", "go_ids": [], "go_terms": [], "name": "C11orf97-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040430": {"description": "Putative transcriptional regulator CudA-like", "go_ids": [], "go_terms": [], "name": "CudA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040431": {"description": "Cation channel sperm-associated auxiliary subunit TMEM262", "go_ids": [], "go_terms": [], "name": "TM262", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040433": {"description": "Spermatid nuclear transition protein", "go_ids": [], "go_terms": [], "name": "Spermatid_TP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040434": {"description": "tRNA selenocysteine 1-associated protein 1", "go_ids": [], "go_terms": [], "name": "TSAP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040435": {"description": "Putative G protein-coupled receptor, Chromadorea", "go_ids": [], "go_terms": [], "name": "Put_GPCR_Chromadorea", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040436": {"description": "Protein disconnected-like", "go_ids": [], "go_terms": [], "name": "Disconnected-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040437": {"description": "Uncharacterized protein F10E9.3-like", "go_ids": [], "go_terms": [], "name": "F10E9.3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040438": {"description": "Protein HIDE1", "go_ids": [], "go_terms": [], "name": "HIDE1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040439": {"description": "Protein FAM237", "go_ids": [], "go_terms": [], "name": "FAM237A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040441": {"description": "Cilia- and flagella-associated protein 20/CFAP20DC", "go_ids": [], "go_terms": [], "name": "CFA20/CFAP20DC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040442": {"description": "Pyruvate kinase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "Pyrv_kinase-like_dom_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-163765", "R-MMU-70268", "R-MMU-70171", "R-SPO-6798695", "R-CFA-70171", "R-DDI-6798695", "R-SCE-70171", "R-DDI-9861718", "R-DME-6798695", "R-SPO-70268", "R-MMU-9861718", "R-DME-70171", "R-SCE-6798695", "R-HSA-210745", "R-HSA-9764725", "R-DDI-70171", "R-DME-9861718", "R-HSA-70268", "R-HSA-9861718", "R-DME-70268", "R-RNO-70171", "R-GGA-352882", "R-RNO-70268", "R-DDI-70268", "R-CFA-70268", "R-MMU-6798695", "R-HSA-9692914", "R-HSA-70171", "R-SPO-70171", "R-SCE-70268"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-MMU-70268:r:Pyruvate metabolism", "R-MMU-70171:r:Glycolysis", "R-SPO-6798695:r:Neutrophil degranulation", "R-CFA-70171:r:Glycolysis", "R-DDI-6798695:r:Neutrophil degranulation", "R-SCE-70171:r:Glycolysis", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-SPO-70268:r:Pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DME-70171:r:Glycolysis", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-210745:r:Regulation of gene expression in beta cells", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DDI-70171:r:Glycolysis", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-DME-70268:r:Pyruvate metabolism", "R-RNO-70171:r:Glycolysis", "R-GGA-352882:r:Glycolysis", "R-RNO-70268:r:Pyruvate metabolism", "R-DDI-70268:r:Pyruvate metabolism", "R-CFA-70268:r:Pyruvate metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9692914:r:SARS-CoV-1-host interactions", "R-HSA-70171:r:Glycolysis", "R-SPO-70171:r:Glycolysis", "R-SCE-70268:r:Pyruvate metabolism"], "type": "Homologous_superfamily"}, "IPR040443": {"description": "PH_15 domain", "go_ids": [], "go_terms": [], "name": "PH_15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040444": {"description": "PCNA-associated factor", "go_ids": ["GO:0006974", "GO:0051726"], "go_terms": ["GO:0006974:DNA damage response:P", "GO:0051726:regulation of cell cycle:P"], "name": "PCNA-AF", "pathway_ids": ["R-MMU-5656169", "R-BTA-5656169", "R-XTR-5656169", "R-RNO-5656169", "R-HSA-5656169"], "pathways": ["R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-XTR-5656169:r:Termination of translesion DNA synthesis", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656169:r:Termination of translesion DNA synthesis"], "type": "Family"}, "IPR040445": {"description": "Potassium channel, inwardly rectifying, transmembrane domain", "go_ids": [], "go_terms": [], "name": "Kir_TM", "pathway_ids": ["R-HSA-1296053", "R-SSC-1296053", "R-RNO-1296053", "R-MMU-422356", "R-MMU-1296025", "R-RNO-382556", "R-HSA-5576886", "R-GGA-5576886", "R-MMU-1296067", "R-CEL-1296067", "R-MMU-1296053", "R-CFA-997272", "R-BTA-1296041", "R-RNO-1296025", "R-HSA-9729555", "R-GGA-997272", "R-CFA-1296053", "R-HSA-1296041", "R-HSA-5578775", "R-CEL-5576886", "R-BTA-997272", "R-HSA-1296025", "R-SSC-997272", "R-HSA-997272", "R-HSA-1296067", "R-MMU-382556", "R-SSC-5576886", "R-RNO-997272", "R-RNO-5578775", "R-HSA-382556", "R-MMU-5578775", "R-MMU-5576886", "R-CFA-5576886", "R-MMU-1296041", "R-RNO-5576886", "R-RNO-1296041", "R-HSA-5678420", "R-BTA-1296053", "R-RNO-422356", "R-CEL-1296053", "R-GGA-1296053", "R-RNO-1296067", "R-MMU-997272", "R-BTA-5576886", "R-SSC-1296041", "R-GGA-1296041", "R-CFA-1296041", "R-CEL-997272", "R-CEL-1296041", "R-HSA-5683177", "R-HSA-422356"], "pathways": ["R-HSA-1296053:r:Classical Kir channels", "R-SSC-1296053:r:Classical Kir channels", "R-RNO-1296053:r:Classical Kir channels", "R-MMU-422356:r:Regulation of insulin secretion", "R-MMU-1296025:r:ATP sensitive Potassium channels", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5576886:r:Phase 4 - resting membrane potential", "R-GGA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296067:r:Potassium transport channels", "R-CEL-1296067:r:Potassium transport channels", "R-MMU-1296053:r:Classical Kir channels", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-1296025:r:ATP sensitive Potassium channels", "R-HSA-9729555:r:Sensory perception of sour taste", "R-GGA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CFA-1296053:r:Classical Kir channels", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5578775:r:Ion homeostasis", "R-CEL-5576886:r:Phase 4 - resting membrane potential", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296025:r:ATP sensitive Potassium channels", "R-SSC-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296067:r:Potassium transport channels", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-SSC-5576886:r:Phase 4 - resting membrane potential", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-5576886:r:Phase 4 - resting membrane potential", "R-CFA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-5576886:r:Phase 4 - resting membrane potential", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5678420:r:Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome", "R-BTA-1296053:r:Classical Kir channels", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-1296053:r:Classical Kir channels", "R-GGA-1296053:r:Classical Kir channels", "R-RNO-1296067:r:Potassium transport channels", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-5576886:r:Phase 4 - resting membrane potential", "R-SSC-1296041:r:Activation of G protein gated Potassium channels", "R-GGA-1296041:r:Activation of G protein gated Potassium channels", "R-CFA-1296041:r:Activation of G protein gated Potassium channels", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5683177:r:Defective ABCC8 can cause hypo- and hyper-glycemias", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR040446": {"description": "Ribosomal RNA-processing protein 7", "go_ids": [], "go_terms": [], "name": "RRP7", "pathway_ids": ["R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR040447": {"description": "Rrp7, RRM-like N-terminal domain", "go_ids": [], "go_terms": [], "name": "RRM_Rrp7", "pathway_ids": ["R-SCE-6791226", "R-MMU-6791226", "R-HSA-6790901", "R-HSA-6791226"], "pathways": ["R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR040448": {"description": "PanZ, acetyltransferase (GNAT) domain", "go_ids": [], "go_terms": [], "name": "PanZ_GNAT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040449": {"description": "LD-carboxypeptidase, N-terminal", "go_ids": [], "go_terms": [], "name": "Peptidase_S66_N", "pathway_ids": ["PWY-6470", "PWY-5707", "PWY-5706", "PWY-7614"], "pathways": ["PWY-6470:t:peptidoglycan biosynthesis V (beta-lactam resistance)", "PWY-5707:t:propanethial S-oxide biosynthesis", "PWY-5706:t:alliin metabolism", "PWY-7614:t:methiin metabolism"], "type": "Domain"}, "IPR040450": {"description": "TFIIF beta subunit, HTH domain", "go_ids": [], "go_terms": [], "name": "TFIIF_beta_HTH", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-CEL-72165", "R-MMU-9770562", "R-RNO-73779", "R-CEL-72203", "R-DDI-73776", "R-DME-72163", "R-RNO-72163", "R-DME-75955", "R-DDI-72163", "R-HSA-167158", "R-RNO-9018519", "R-MMU-75955", "R-RNO-73776", "R-MMU-112382", "R-BTA-9018519", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DME-72086", "R-DME-72203", "R-BTA-77075", "R-DDI-674695", "R-CEL-9770562", "R-CEL-75953", "R-SPO-6796648", "R-DME-75953", "R-CEL-73776", "R-BTA-72163", "R-BTA-75955", "R-BTA-75953", "R-SPO-9018519", "R-MMU-72163", "R-HSA-6803529", "R-HSA-167242", "R-HSA-8851708", "R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-CEL-112382", "R-HSA-167160", "R-DDI-77075", "R-SPO-73779", "R-DDI-113418", "R-MMU-72086", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DME-77075", "R-DME-73779", "R-DME-9770562", "R-DME-73776", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-72165", "R-DDI-76042", "R-MMU-73776", "R-CEL-72163", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-DME-113418", "R-RNO-113418", "R-HSA-72203", "R-CEL-75955", "R-MMU-6796648", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-RNO-6796648", "R-RNO-75955", "R-BTA-674695", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-167290", "R-RNO-77075", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-CEL-9018519", "R-RNO-9770562", "R-HSA-76042", "R-HSA-674695", "R-BTA-6807505", "R-BTA-72203", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-RNO-6807505", "R-MMU-72203", "R-HSA-167238", "R-RNO-674695", "R-SCE-75953", "R-DME-76042", "R-MMU-113418", "R-BTA-76042", "R-SPO-6807505", "R-HSA-6796648", "R-HSA-167287", "R-HSA-167246", "R-RNO-72165", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-HSA-9018519", "R-MMU-76042", "R-SPO-75953", "R-SPO-113418", "R-CEL-6807505", "R-DME-674695", "R-RNO-72203", "R-RNO-76042", "R-DME-9018519", "R-BTA-72086", "R-DDI-73779", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-CEL-113418", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-MMU-9018519", "R-DME-6807505", "R-SPO-9770562", "R-HSA-167200", "R-DME-72165", "R-RNO-112382", "R-SCE-674695", "R-BTA-9770562", "R-CEL-6796648", "R-RNO-75953", "R-MMU-6803529", "R-BTA-113418", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-HSA-167152", "R-HSA-113418", "R-BTA-112382", "R-HSA-9918481", "R-RNO-6803529", "R-BTA-6796648", "R-SPO-72203", "R-SCE-72203", "R-SCE-6796648", "R-RNO-72086", "R-SPO-77075", "R-SCE-113418", "R-SCE-72086", "R-CEL-77075", "R-SCE-77075", "R-DDI-75953", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72086:r:mRNA Capping", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-BTA-72086:r:mRNA Capping", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Domain"}, "IPR040451": {"description": "Glycosyl hydrolase family 81, N-terminal", "go_ids": [], "go_terms": [], "name": "GH81_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040452": {"description": "Sugar fermentation stimulation protein, C-terminal", "go_ids": [], "go_terms": [], "name": "SfsA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040453": {"description": "Mnd1, HTH domain", "go_ids": [], "go_terms": [], "name": "Mnd1_HTH", "pathway_ids": ["R-HSA-912446"], "pathways": ["R-HSA-912446:r:Meiotic recombination"], "type": "Domain"}, "IPR040454": {"description": "Transcription factor IIIC subunit Tfc1/Sfc1", "go_ids": ["GO:0000127", "GO:0006384"], "go_terms": ["GO:0000127:transcription factor TFIIIC complex:C", "GO:0006384:transcription initiation at RNA polymerase III promoter:P"], "name": "TF_IIIC_Tfc1/Sfc1", "pathway_ids": ["R-SCE-76066", "R-DDI-76066", "R-DDI-76061", "R-SPO-76066", "R-HSA-76066", "R-MMU-76061", "R-HSA-76061", "R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR040455": {"description": "Atg6, BARA domain", "go_ids": [], "go_terms": [], "name": "Atg6_BARA", "pathway_ids": ["R-DRE-5689880", "R-HSA-9694676", "R-DDI-1632852", "R-HSA-9705671", "R-BTA-5689880", "R-HSA-5689880", "R-MMU-1632852", "R-CEL-1632852", "R-RNO-1169408", "R-HSA-1169408", "R-MMU-1169408", "R-BTA-1632852", "R-RNO-5689880", "R-CEL-5689880", "R-MMU-5689880", "R-SCE-1632852", "R-HSA-983170", "R-CEL-1169408", "R-RNO-1632852", "R-XTR-1632852", "R-DDI-5689880", "R-HSA-1632852", "R-DME-1632852", "R-HSA-9833110", "R-HSA-9920951", "R-SPO-1632852", "R-BTA-1169408", "R-HSA-9679504", "R-DME-5689880", "R-DDI-1169408"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DDI-1632852:r:Macroautophagy", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-BTA-1632852:r:Macroautophagy", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-1632852:r:Macroautophagy", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SPO-1632852:r:Macroautophagy", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DME-5689880:r:Ub-specific processing proteases", "R-DDI-1169408:r:ISG15 antiviral mechanism"], "type": "Domain"}, "IPR040456": {"description": "Ribonuclease H2 subunit B", "go_ids": ["GO:0032299"], "go_terms": ["GO:0032299:ribonuclease H2 complex:C"], "name": "RNase_H2_suB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040457": {"description": "Gamma tubulin complex component, C-terminal", "go_ids": ["GO:0043015"], "go_terms": ["GO:0043015:gamma-tubulin binding:F"], "name": "GCP_C", "pathway_ids": ["R-HSA-380320", "R-MMU-380270", "R-HSA-380270", "R-MMU-380320"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes"], "type": "Domain"}, "IPR040458": {"description": "Vacuolar import/degradation Vid27", "go_ids": [], "go_terms": [], "name": "Vid27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040459": {"description": "MJ1316 RNA cyclic group end recognition domain", "go_ids": [], "go_terms": [], "name": "MJ1316", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040460": {"description": "Gasdermin, pore forming domain", "go_ids": [], "go_terms": [], "name": "Gasdermin_pore", "pathway_ids": ["R-HSA-6798695", "R-MMU-9960525", "R-HSA-9960525", "R-HSA-9662361", "R-HSA-5620971", "R-HSA-9660826", "R-MMU-5686938", "R-HSA-9960519", "R-HSA-9710421", "R-HSA-111457", "R-HSA-448706", "R-MMU-448706", "R-HSA-9662360", "R-MMU-9960519", "R-MMU-111457", "R-MMU-6798695", "R-MMU-5620971", "R-HSA-5686938"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-5620971:r:Pyroptosis", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9960519:r:CASP4-mediated substrate cleavage", "R-HSA-9710421:r:Defective pyroptosis", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-448706:r:Interleukin-1 processing", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5620971:r:Pyroptosis", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand"], "type": "Domain"}, "IPR040462": {"description": "Protein EARLY FLOWERING 4", "go_ids": ["GO:0042753"], "go_terms": ["GO:0042753:positive regulation of circadian rhythm:P"], "name": "EARLY_FLOWERING_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040463": {"description": "BAP29/BAP31, transmembrane domain", "go_ids": [], "go_terms": [], "name": "BAP29/BAP31_N", "pathway_ids": ["R-HSA-983170", "R-SCE-75153", "R-HSA-8980692", "R-MMU-983170", "R-MMU-111465", "R-HSA-111465", "R-MMU-8980692", "R-HSA-9833110", "R-SPO-75153", "R-HSA-75153", "R-DDI-75153", "R-MMU-75153"], "pathways": ["R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-75153:r:Apoptotic execution phase", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9833110:r:RSV-host interactions", "R-SPO-75153:r:Apoptotic execution phase", "R-HSA-75153:r:Apoptotic execution phase", "R-DDI-75153:r:Apoptotic execution phase", "R-MMU-75153:r:Apoptotic execution phase"], "type": "Domain"}, "IPR040464": {"description": "Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain", "go_ids": [], "go_terms": [], "name": "InsP(3)kin_ATP-grasp", "pathway_ids": ["PWY-6366", "PWY-6554", "PWY-6362", "PWY-6372", "PWY-4661", "PWY-6365", "R-MMU-983231", "R-GGA-983231", "R-BTA-1855204", "R-HSA-1855167", "R-MMU-1855167", "R-HSA-1855204", "R-BTA-1855167", "R-HSA-983231", "R-GGA-1855167", "R-MMU-1855204", "R-GGA-1855204", "R-BTA-983231"], "pathways": ["PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6554:t:1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)", "PWY-6362:t:1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)", "PWY-6372:t:1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)", "PWY-4661:t:1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-GGA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR040465": {"description": "CtsR, N-terminal HTH domain", "go_ids": [], "go_terms": [], "name": "CtsR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040466": {"description": "NF-kappa-B-activating protein", "go_ids": [], "go_terms": [], "name": "NKAP", "pathway_ids": ["R-HSA-72163", "R-RNO-72163", "R-DME-72163", "R-DDI-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR040467": {"description": "CCDC66 domain", "go_ids": [], "go_terms": [], "name": "CCDC66_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040468": {"description": "TRAF3-interacting protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "TRAF3IP1_N", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR040470": {"description": "Vexin", "go_ids": ["GO:0022008"], "go_terms": ["GO:0022008:neurogenesis:P"], "name": "Vexin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040472": {"description": "Synaptic functional regulator FMRP, KH0 domain", "go_ids": [], "go_terms": [], "name": "FMRP_KH0", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR040473": {"description": "NusG, additional domain", "go_ids": [], "go_terms": [], "name": "NusG_add", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040474": {"description": "Ubiquitin-like protein MDY2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MDY2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040475": {"description": "Surface glycan-binding protein B, xyloglucan binding domain", "go_ids": ["GO:0030247"], "go_terms": ["GO:0030247:polysaccharide binding:F"], "name": "SGBP_B_XBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040476": {"description": "RNase II/RNase R, cold shock domain", "go_ids": [], "go_terms": [], "name": "CSD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040477": {"description": "Lysine-specific demethylase 4-like, Tudor domain", "go_ids": [], "go_terms": [], "name": "KDM4-like_Tudor", "pathway_ids": ["R-HSA-212300", "R-MMU-3214842", "R-HSA-9772755", "R-RNO-9772755", "R-HSA-3214842", "R-HSA-9029569", "R-MMU-9772755", "R-HSA-5693565", "R-MMU-212300", "R-HSA-9018519", "R-HSA-5625886", "R-MMU-5693565"], "pathways": ["R-HSA-212300:r:PRC2 methylates histones and DNA", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214842:r:HDMs demethylate histones", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5625886:r:Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR040478": {"description": "BDBT FKBP like, N-terminal", "go_ids": [], "go_terms": [], "name": "FKBP_N_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040479": {"description": "Protein masquerade, clip-domain", "go_ids": [], "go_terms": [], "name": "CLIP_SPH_mas", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040480": {"description": "DnaT, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "DnaT_DNA_bind", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040481": {"description": "DpnII/MboI-like, REase domain", "go_ids": [], "go_terms": [], "name": "REase_DpnII/MboI-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040482": {"description": "Trimeric autotransporter adhesin, Trp ring domain", "go_ids": [], "go_terms": [], "name": "Trp_ring", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040483": {"description": "PatG domain", "go_ids": [], "go_terms": [], "name": "PatG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040484": {"description": "LepB GAP domain, C-terminal subdomain", "go_ids": [], "go_terms": [], "name": "LepB_GAP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040485": {"description": "Exportin-1, repeat 3", "go_ids": [], "go_terms": [], "name": "XPO1_repeat_3", "pathway_ids": ["R-MMU-9856649", "R-DME-69273", "R-DME-9634638", "R-HSA-2467813", "R-HSA-3769402", "R-SPO-5687128", "R-DME-9707616", "R-RNO-2500257", "R-MMU-2467813", "R-SCE-9856649", "R-HSA-69273", "R-RNO-450520", "R-RNO-5687128", "R-MMU-68877", "R-RNO-9634638", "R-HSA-168333", "R-HSA-9828806", "R-HSA-68877", "R-MMU-9707616", "R-HSA-165054", "R-RNO-9707616", "R-RNO-141444", "R-MMU-9648025", "R-MMU-2500257", "R-MMU-3769402", "R-RNO-68877", "R-HSA-2500257", "R-DDI-5687128", "R-MMU-141444", "R-RNO-9856649", "R-HSA-9918432", "R-DME-9856649", "R-HSA-141444", "R-HSA-450520", "R-HSA-9707616", "R-MMU-450520", "R-HSA-9648025", "R-DME-450520", "R-HSA-9634638", "R-RNO-5663220", "R-RNO-69273", "R-DME-3769402", "R-HSA-5687128", "R-HSA-9856649", "R-HSA-5663220", "R-MMU-9634638", "R-MMU-5687128", "R-SCE-5687128", "R-MMU-69273", "R-HSA-2173788", "R-RNO-9648025", "R-RNO-2467813", "R-RNO-3769402", "R-MMU-5663220", "R-HSA-9768919"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-DME-9707616:r:Heme signaling", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-9707616:r:Heme signaling", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-9707616:r:Heme signaling", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9707616:r:Heme signaling", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Repeat"}, "IPR040487": {"description": "Peptidase family M23, N-terminal", "go_ids": [], "go_terms": [], "name": "Peptidase_M23_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040489": {"description": "Flax-rust effector AvrM-A", "go_ids": [], "go_terms": [], "name": "AvrM-A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040491": {"description": "Domain of unknown function DUF5626", "go_ids": [], "go_terms": [], "name": "DUF5626", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040492": {"description": "Galactofuranosyltransferase GlfT2, N-terminal", "go_ids": [], "go_terms": [], "name": "GlfT2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040493": {"description": "Protein of unknown function DUF5518", "go_ids": [], "go_terms": [], "name": "DUF5518", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040494": {"description": "DNA topoisomerase VI, subunit B, C-terminal", "go_ids": [], "go_terms": [], "name": "Top6b_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040495": {"description": "CCDC81-like prokaryotic HU domain 1", "go_ids": [], "go_terms": [], "name": "HU-CCDC81_bac_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040496": {"description": "Prokaryotic pPIWI_RE, MID domain", "go_ids": [], "go_terms": [], "name": "MID_pPIWI_RE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040497": {"description": "Glucosyltransferase 24, catalytic domain", "go_ids": [], "go_terms": [], "name": "Glyco_transf_24", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-901032"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)"], "type": "Domain"}, "IPR040498": {"description": "PriA DNA helicase, Cys-rich region (CRR) domain", "go_ids": [], "go_terms": [], "name": "PriA_CRR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040501": {"description": "TFA2, Winged helix domain 2", "go_ids": [], "go_terms": [], "name": "TFA2_Winged_2", "pathway_ids": ["R-SCE-73779", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-DDI-73779", "R-SCE-75953", "R-SPO-6807505", "R-DDI-73776", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-HSA-167162", "R-HSA-167161", "R-DDI-6807505", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-HSA-73779", "R-DDI-674695", "R-HSA-75953", "R-SCE-674695", "R-SPO-73779", "R-MMU-73776", "R-DDI-76042", "R-HSA-76042", "R-HSA-674695", "R-DDI-75953", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-SPO-73776", "R-SPO-75953", "R-SCE-73776"], "pathways": ["R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167161:r:HIV Transcription Initiation", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR040502": {"description": "Endo-alpha-N-acetylgalactosaminidase, domain 6", "go_ids": [], "go_terms": [], "name": "GH101_dom-6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040503": {"description": "tRNA uridine(34) hydroxylase, N-terminal", "go_ids": [], "go_terms": [], "name": "TRHO_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040504": {"description": "TFIIF, beta subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "TFIIF_beta_N", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-CEL-72165", "R-MMU-9770562", "R-RNO-73779", "R-CEL-72203", "R-DDI-73776", "R-DME-72163", "R-RNO-72163", "R-DME-75955", "R-DDI-72163", "R-HSA-167158", "R-RNO-9018519", "R-MMU-75955", "R-RNO-73776", "R-MMU-112382", "R-BTA-9018519", "R-SCE-6807505", "R-SPO-76042", "R-HSA-73776", "R-DME-72086", "R-DME-72203", "R-BTA-77075", "R-DDI-674695", "R-CEL-9770562", "R-CEL-75953", "R-SPO-6796648", "R-DME-75953", "R-CEL-73776", "R-BTA-72163", "R-BTA-75955", "R-BTA-75953", "R-SPO-9018519", "R-MMU-72163", "R-HSA-6803529", "R-HSA-167242", "R-HSA-8851708", "R-HSA-167161", "R-CEL-674695", "R-HSA-72163", "R-DME-112382", "R-CEL-112382", "R-HSA-167160", "R-DDI-77075", "R-SPO-73779", "R-DDI-113418", "R-MMU-72086", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DME-77075", "R-DME-73779", "R-DME-9770562", "R-DME-73776", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-72165", "R-DDI-76042", "R-MMU-73776", "R-CEL-72163", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-DME-113418", "R-RNO-113418", "R-HSA-72203", "R-CEL-75955", "R-MMU-6796648", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-RNO-6796648", "R-RNO-75955", "R-BTA-674695", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-167290", "R-RNO-77075", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-CEL-9018519", "R-RNO-9770562", "R-HSA-76042", "R-HSA-674695", "R-BTA-6807505", "R-BTA-72203", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-RNO-6807505", "R-MMU-72203", "R-HSA-167238", "R-RNO-674695", "R-SCE-75953", "R-DME-76042", "R-MMU-113418", "R-BTA-76042", "R-SPO-6807505", "R-HSA-6796648", "R-HSA-167287", "R-HSA-167246", "R-RNO-72165", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-HSA-9018519", "R-MMU-76042", "R-SPO-75953", "R-SPO-113418", "R-CEL-6807505", "R-DME-674695", "R-RNO-72203", "R-RNO-76042", "R-DME-9018519", "R-BTA-72086", "R-DDI-73779", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-CEL-113418", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-MMU-9018519", "R-DME-6807505", "R-SPO-9770562", "R-HSA-167200", "R-DME-72165", "R-RNO-112382", "R-SCE-674695", "R-BTA-9770562", "R-CEL-6796648", "R-RNO-75953", "R-MMU-6803529", "R-BTA-113418", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-HSA-167152", "R-HSA-113418", "R-BTA-112382", "R-HSA-9918481", "R-RNO-6803529", "R-BTA-6796648", "R-SPO-72203", "R-SCE-72203", "R-SCE-6796648", "R-RNO-72086", "R-SPO-77075", "R-SCE-113418", "R-SCE-72086", "R-CEL-77075", "R-SCE-77075", "R-DDI-75953", "R-CEL-76042", "R-CEL-6803529"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72086:r:mRNA Capping", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-9770562:r:mRNA Polyadenylation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-BTA-72086:r:mRNA Capping", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-72086:r:mRNA Capping", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Domain"}, "IPR040505": {"description": "Family of unknown function DUF5537", "go_ids": [], "go_terms": [], "name": "DUF5537", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040506": {"description": "RACo linker region", "go_ids": [], "go_terms": [], "name": "RACo_linker", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040507": {"description": "Protein of unknown function DUF5540", "go_ids": [], "go_terms": [], "name": "DUF5540", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040508": {"description": "AbiJ, N-terminal domain 5", "go_ids": [], "go_terms": [], "name": "AbiJ_NTD5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040509": {"description": "CdiI, C-terminal", "go_ids": [], "go_terms": [], "name": "CdiI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040510": {"description": "Astrotactin-2, C-terminal beta-hairpin domain", "go_ids": [], "go_terms": [], "name": "ASTN_2_hairpin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040511": {"description": "Adenylyl/Guanylyl and SMODS, C-terminal sensor domain", "go_ids": [], "go_terms": [], "name": "AGS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040512": {"description": "Large polyvalent-protein-associated domain 15", "go_ids": [], "go_terms": [], "name": "LPD15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040513": {"description": "Mutator 2, fork head associated domain", "go_ids": [], "go_terms": [], "name": "MU2_FHA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040514": {"description": "C4b-binding protein alpha, oligomerization domain", "go_ids": [], "go_terms": [], "name": "C4bp_oligo", "pathway_ids": ["R-HSA-977606", "R-HSA-9920588"], "pathways": ["R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses"], "type": "Domain"}, "IPR040516": {"description": "Phosphoethanolamine N-methyltransferase 2, N-terminal", "go_ids": [], "go_terms": [], "name": "PMT2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040517": {"description": "Nucleotidyltransferase, substrate binding domain", "go_ids": [], "go_terms": [], "name": "Ant(4')-IIb_substrate-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040518": {"description": "Chalcone isomerase, N-terminal", "go_ids": [], "go_terms": [], "name": "Chalcone_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040519": {"description": "LepB, N-terminal", "go_ids": [], "go_terms": [], "name": "LepB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040520": {"description": "Importin 13 repeat", "go_ids": [], "go_terms": [], "name": "Importin_rep_3", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040521": {"description": "Kyakuja-Dileera-Zisupton transposase", "go_ids": [], "go_terms": [], "name": "KDZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040522": {"description": "Dipeptidyl peptidase 4, low complexity region", "go_ids": [], "go_terms": [], "name": "DPPIV_rep", "pathway_ids": ["R-MMU-400511", "R-BTA-381771", "R-RNO-381771", "R-MMU-381771", "R-BTA-400511", "R-RNO-400511"], "pathways": ["R-MMU-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-BTA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-RNO-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-MMU-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-BTA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-RNO-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Domain"}, "IPR040523": {"description": "Siroheme decarboxylase , AsnC-like ligand binding domain", "go_ids": [], "go_terms": [], "name": "AsnC_trans_reg2", "pathway_ids": ["PWY-7552", "PWY-7554"], "pathways": ["PWY-7552:t:heme b biosynthesis III (from siroheme)", "PWY-7554:t:heme d1 biosynthesis"], "type": "Domain"}, "IPR040524": {"description": "E3 ubiquitin-protein ligase HECW1, helical box domain", "go_ids": [], "go_terms": [], "name": "HECW1_helix", "pathway_ids": ["PWY-7511", "R-HSA-4641258", "R-HSA-983168", "R-MMU-4641258", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-4641258:r:Degradation of DVL", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-4641258:r:Degradation of DVL", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR040525": {"description": "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4", "go_ids": [], "go_terms": [], "name": "UGGT_TRXL_4", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-901032"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)"], "type": "Domain"}, "IPR040526": {"description": "Inulin fructotransferase, beta helix repeat", "go_ids": [], "go_terms": [], "name": "Beta_helix_2", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040527": {"description": "Porphyranase, beta-sandwich domain 1", "go_ids": [], "go_terms": [], "name": "Beta-sand_Porphyrn", "pathway_ids": ["PWY-6815", "PWY-6816"], "pathways": ["PWY-6815:t:porphyran degradation", "PWY-6816:t:agarose degradation"], "type": "Domain"}, "IPR040528": {"description": "Lectin-like domain", "go_ids": [], "go_terms": [], "name": "Lectin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040530": {"description": "Type VI secretion system TssR-like, N-terminal barrel domain", "go_ids": [], "go_terms": [], "name": "T6SS_TssR-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040531": {"description": "Domain of unknown function DUF5623", "go_ids": [], "go_terms": [], "name": "DUF5623", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040532": {"description": "MapZ, extracellular C-terminal domain 2", "go_ids": [], "go_terms": [], "name": "MapZ_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040533": {"description": "Elongation factor 3, four helical bundle domain", "go_ids": [], "go_terms": [], "name": "EF3_4HB", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR040534": {"description": "Calcium binding protein SSO6904", "go_ids": [], "go_terms": [], "name": "Ca_bind_SSO6904", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040535": {"description": "NLRC4, helical domain", "go_ids": [], "go_terms": [], "name": "NLRC4_HD", "pathway_ids": ["R-HSA-6803207", "R-HSA-844623"], "pathways": ["R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR040536": {"description": "ASP external chaperone", "go_ids": [], "go_terms": [], "name": "ASPCH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040537": {"description": "Domain of unknown function DUF5612", "go_ids": [], "go_terms": [], "name": "DUF5612", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040538": {"description": "Cch, helix turn helix domain", "go_ids": [], "go_terms": [], "name": "Cch_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040539": {"description": "WRNIP1, ubiquitin-binding domain", "go_ids": [], "go_terms": [], "name": "Znf-WRNIP1_ubi", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR040540": {"description": "Ribonuclease III, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RNase_3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040541": {"description": "Metanogen output domain 2", "go_ids": [], "go_terms": [], "name": "MetOD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040542": {"description": "HMW1 domain 2", "go_ids": [], "go_terms": [], "name": "HMW1_D2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040545": {"description": "DICER-like, HTH domain", "go_ids": [], "go_terms": [], "name": "DICER_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040546": {"description": "Rege-1, UBA-like domain", "go_ids": [], "go_terms": [], "name": "Rege-1_UBA-like", "pathway_ids": ["R-HSA-9764302"], "pathways": ["R-HSA-9764302:r:Regulation of CDH19 Expression and Function"], "type": "Domain"}, "IPR040547": {"description": "Immunity protein CdiI", "go_ids": [], "go_terms": [], "name": "CdiI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040548": {"description": "BepA, intracellular delivery domain", "go_ids": [], "go_terms": [], "name": "BepA_ID", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040549": {"description": "Domain of unknown function DUF5613", "go_ids": [], "go_terms": [], "name": "DUF5613", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040550": {"description": "Prim-pol family 5", "go_ids": [], "go_terms": [], "name": "PPL5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040552": {"description": "DNMT3, cysteine rich ADD domain, GATA1-like zinc finger", "go_ids": [], "go_terms": [], "name": "DNMT3_ADD_GATA1-like", "pathway_ids": ["R-HSA-4655427", "R-RNO-212300", "R-HSA-212300", "R-MMU-4655427", "R-HSA-9845323", "R-RNO-3214858", "R-HSA-427413", "R-MMU-212300", "R-HSA-5334118", "R-HSA-3214858", "R-MMU-3214858", "R-HSA-9710421"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-MMU-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-5334118:r:DNA methylation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-HSA-9710421:r:Defective pyroptosis"], "type": "Domain"}, "IPR040553": {"description": "Toxoflavin-degrading enzyme", "go_ids": [], "go_terms": [], "name": "TxDE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040554": {"description": "Peroxisomal membrane protein PEX14-like, KPWE domain", "go_ids": [], "go_terms": [], "name": "KPWE_PEX14_dom", "pathway_ids": ["R-DDI-9033241", "R-DDI-9603798", "R-DDI-8866654"], "pathways": ["R-DDI-9033241:r:Peroxisomal protein import", "R-DDI-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Domain"}, "IPR040555": {"description": "Cas9, PI domain", "go_ids": [], "go_terms": [], "name": "Cas9_PI2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040556": {"description": "Predicted pPIWI-associating nuclease", "go_ids": [], "go_terms": [], "name": "pP_pnuc_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040557": {"description": "VIP1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "VIP1-like_N", "pathway_ids": ["PWY-6369", "R-HSA-1855167", "R-MMU-1855167", "R-SPO-1855167", "R-BTA-1855167", "R-DME-1855167", "R-CEL-1855167", "R-SCE-1855167", "R-RNO-1855167"], "pathways": ["PWY-6369:t:inositol diphosphates biosynthesis", "R-HSA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-SPO-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-BTA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-DME-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-CEL-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-SCE-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-RNO-1855167:r:Synthesis of pyrophosphates in the cytosol"], "type": "Domain"}, "IPR040559": {"description": "tRNA nuclease CdiA, C-terminal", "go_ids": [], "go_terms": [], "name": "CdiA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040560": {"description": "Synaptonemal complex protein 2, Spt16M-like domain", "go_ids": [], "go_terms": [], "name": "SYCP2_SLD", "pathway_ids": ["R-HSA-1221632"], "pathways": ["R-HSA-1221632:r:Meiotic synapsis"], "type": "Domain"}, "IPR040561": {"description": "Large polyvalent protein associated domain 38", "go_ids": [], "go_terms": [], "name": "LPD38", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040562": {"description": "Prim-pol 4", "go_ids": [], "go_terms": [], "name": "PPL4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040564": {"description": "CxC3 like cysteine cluster", "go_ids": [], "go_terms": [], "name": "CxC3-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040565": {"description": "Benzylsuccinate synthase beta subunit", "go_ids": [], "go_terms": [], "name": "BssB_TutG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040566": {"description": "Interleukin-13 receptor subunit alpha-1, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Il13Ra_Ig", "pathway_ids": ["R-MMU-6785807", "R-HSA-6785807"], "pathways": ["R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling"], "type": "Domain"}, "IPR040567": {"description": "RctB, helix turn helix domain", "go_ids": [], "go_terms": [], "name": "RctB_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040568": {"description": "Large polyvalent protein-associated domain 16", "go_ids": [], "go_terms": [], "name": "LPD16", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040569": {"description": "Reverse gyrase, zinc finger", "go_ids": [], "go_terms": [], "name": "Znf_Rg", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040570": {"description": "L-amino acid ligase, C-terminal domain 2", "go_ids": [], "go_terms": [], "name": "LAL_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040571": {"description": "Mitochondrial membrane-anchored protein", "go_ids": [], "go_terms": [], "name": "MIX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040572": {"description": "Thaumarchaeal output domain 1", "go_ids": [], "go_terms": [], "name": "TackOD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040573": {"description": "Tail specific protease, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TSP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040574": {"description": "V-type ATP synthase subunit I, N-terminal", "go_ids": [], "go_terms": [], "name": "V_ATPase_I_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040575": {"description": "Endo-alpha-N-acetylgalactosaminidase, N-terminal", "go_ids": [], "go_terms": [], "name": "GH101_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040576": {"description": "Dynamin-like helical domain", "go_ids": [], "go_terms": [], "name": "DLP_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040577": {"description": "Glutamine synthetase, C-terminal", "go_ids": [], "go_terms": [], "name": "Gln-synt_C", "pathway_ids": ["PWY-6964", "PWY-8294", "PWY-8291", "PWY-6963"], "pathways": ["PWY-6964:t:ammonia assimilation cycle II", "PWY-8294:t:L-aspartate degradation III (anaerobic)", "PWY-8291:t:L-aspartate degradation II (aerobic)", "PWY-6963:t:ammonia assimilation cycle I"], "type": "Domain"}, "IPR040578": {"description": "UPF0242, C-terminal PAS-like domain", "go_ids": [], "go_terms": [], "name": "UPF0242_PAS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040579": {"description": "Acetyltransferase (GNAT) domain", "go_ids": [], "go_terms": [], "name": "Acetyltransf_19", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040580": {"description": "Domain of unknown function DUF5627", "go_ids": [], "go_terms": [], "name": "DUF5627", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040581": {"description": "SNTX, thioredoxin-like domain", "go_ids": [], "go_terms": [], "name": "Thioredoxin_11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040582": {"description": "MalK-like, OB fold domain", "go_ids": [], "go_terms": [], "name": "OB_MalK-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040586": {"description": "PheRS DNA binding domain 2", "go_ids": [], "go_terms": [], "name": "PheRS_DBD2", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR040587": {"description": "5-3 exonuclease XRN1, DCP1-binding motif", "go_ids": [], "go_terms": [], "name": "XRN1_DBM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040588": {"description": "Argonaute, N domain", "go_ids": [], "go_terms": [], "name": "AGO_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040591": {"description": "Ribosome-associated protein quality control protein P2, RNA-binding domain", "go_ids": [], "go_terms": [], "name": "RqcP2_RBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040592": {"description": "TbRIF5 SNase domain 2", "go_ids": [], "go_terms": [], "name": "RIF5_SNase_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040593": {"description": "Spindle pole body component 110, C-terminal", "go_ids": [], "go_terms": [], "name": "Spc110_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040594": {"description": "Unkempt, zinc finger domain 1", "go_ids": [], "go_terms": [], "name": "UNK_Znf_1", "pathway_ids": ["R-DME-983168", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR040595": {"description": "EZH2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "EZH2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040596": {"description": "RNase II-type exonuclease, C-terminal S1 domain", "go_ids": [], "go_terms": [], "name": "RNase_II_C_S1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040597": {"description": "Hemagglutinin component HA-70, C-terminal", "go_ids": [], "go_terms": [], "name": "HA70_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040598": {"description": "60S ribosome subunit biogenesis protein NIP7, pre-PUA domain", "go_ids": [], "go_terms": [], "name": "NIP7_N", "pathway_ids": ["R-MMU-6791226", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR040599": {"description": "Pilin PilJ, C-terminal", "go_ids": [], "go_terms": [], "name": "PilJ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040600": {"description": "Agglutinin, C-terminal", "go_ids": [], "go_terms": [], "name": "Agglutinin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040601": {"description": "tRNA methyltransferase 5a/b, N-terminal", "go_ids": [], "go_terms": [], "name": "Trm5a/b_N", "pathway_ids": ["PWY-7286", "PWY-7285", "PWY-6829"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-6829:t:tRNA methylation (yeast)"], "type": "Domain"}, "IPR040602": {"description": "Cucumopine synthase, C-terminal helical bundle domain", "go_ids": [], "go_terms": [], "name": "Cucumopine_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040603": {"description": "Fanconi-associated nuclease 1, SAP domain, bacteria", "go_ids": [], "go_terms": [], "name": "FAN1_SAP_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040604": {"description": "Domain of unknown function DUF5632", "go_ids": [], "go_terms": [], "name": "DUF5632", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040605": {"description": "Glycoside hydrolase family 2, domain 5", "go_ids": [], "go_terms": [], "name": "Glyco_hydro2_dom5", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR040606": {"description": "piRNA-mediated silencing protein C19orf84", "go_ids": [], "go_terms": [], "name": "C19orf84", "pathway_ids": ["R-HSA-9845323"], "pathways": ["R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)"], "type": "Family"}, "IPR040607": {"description": "Actin-like protein, N-terminal", "go_ids": [], "go_terms": [], "name": "ALP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040608": {"description": "Snf8/Vps36 family", "go_ids": [], "go_terms": [], "name": "Snf8/Vps36", "pathway_ids": ["R-RNO-917729", "R-HSA-917729", "R-HSA-9610379", "R-XTR-917729", "R-DRE-917729", "R-DME-917729", "R-MMU-917729", "R-SPO-917729", "R-DDI-917729", "R-SCE-917729"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-XTR-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SPO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SCE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Family"}, "IPR040609": {"description": "RNA ligase 2, C-terminal", "go_ids": [], "go_terms": [], "name": "Rnl2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040610": {"description": "SNRNP25, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "SNRNP25_ubiquitin", "pathway_ids": ["R-BTA-72165", "R-MMU-72165", "R-HSA-72165"], "pathways": ["R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway"], "type": "Domain"}, "IPR040611": {"description": "HTH-type transcriptional regulator AlkX, C-terminal, Actinobacteria", "go_ids": [], "go_terms": [], "name": "AlkX_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040612": {"description": "ArsA, HSP20-like domain", "go_ids": [], "go_terms": [], "name": "ArsA_HSP20-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040613": {"description": "Nucleotide modification associated domain 4", "go_ids": [], "go_terms": [], "name": "Nmad4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040614": {"description": "Integron cassette protein VCH_CASS1 chain", "go_ids": [], "go_terms": [], "name": "VCH_CASS14", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040618": {"description": "Pre-nudix hydrolase domain", "go_ids": [], "go_terms": [], "name": "Pre-Nudix", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-5381", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "PWY-7761"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-5381:t:NAD salvage (plants)", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "PWY-7761:t:NAD salvage pathway II (PNC IV cycle)"], "type": "Domain"}, "IPR040619": {"description": "Cas9, alpha-helical lobe domain", "go_ids": [], "go_terms": [], "name": "Cas9_alpha-helical_lobe", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040620": {"description": "Protein of unknown function DUF5560", "go_ids": [], "go_terms": [], "name": "DUF5560", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040621": {"description": "Avirulence Effector AvrLm4-7", "go_ids": [], "go_terms": [], "name": "AvrLm4-7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040622": {"description": "Integrin beta, epidermal growth factor-like domain 1", "go_ids": [], "go_terms": [], "name": "EGF_integrin_1", "pathway_ids": ["R-BTA-216083", "R-HSA-8874081", "R-HSA-5674135", "R-MMU-210991", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-MMU-9013408", "R-MMU-210990", "R-RNO-9013149", "R-RNO-3000157", "R-HSA-9856532", "R-MMU-445355", "R-MMU-4420097", "R-MMU-9013404", "R-HSA-9927418", "R-BTA-2173789", "R-MMU-3000170", "R-HSA-4420097", "R-RNO-9634597", "R-MMU-3000178", "R-HSA-9649948", "R-HSA-446343", "R-MMU-202733", "R-RNO-202733", "R-RNO-210990", "R-RNO-9013408", "R-HSA-8875513", "R-HSA-9013408", "R-RNO-9013404", "R-MMU-1566948", "R-HSA-446107", "R-HSA-6802955", "R-HSA-210991", "R-RNO-3000178", "R-HSA-2173789", "R-RNO-446343", "R-HSA-6802948", "R-RNO-1566977", "R-RNO-445144", "R-RNO-198933", "R-BTA-1566948", "R-MMU-9634597", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-HSA-9609690", "R-RNO-1566948", "R-HSA-447041", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-75892", "R-MMU-198933", "R-HSA-2022090", "R-MMU-216083", "R-HSA-445144", "R-HSA-198933", "R-MMU-8875513", "R-HSA-9860927", "R-HSA-372708", "R-MMU-354192", "R-MMU-9860927", "R-MMU-446107", "R-HSA-9656223", "R-MMU-114608", "R-RNO-4420097", "R-HSA-9634597", "R-MMU-5674135", "R-RNO-216083", "R-HSA-9725554", "R-HSA-3000157", "R-BTA-3000178", "R-HSA-1566948", "R-RNO-354194", "R-RNO-2129379", "R-RNO-114608", "R-RNO-9860927", "R-HSA-9013423", "R-MMU-372708", "R-HSA-114608", "R-HSA-210990", "R-RNO-8874081", "R-MMU-8874081", "R-RNO-8875513", "R-HSA-416700", "R-RNO-354192", "R-HSA-6802946", "R-HSA-9938206", "R-RNO-5674135", "R-MMU-446343", "R-BTA-2129379", "R-RNO-2173789", "R-HSA-354192", "R-MMU-3000157", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-3000170", "R-MMU-1566977", "R-HSA-216083", "R-HSA-445355", "R-RNO-210991", "R-RNO-446107", "R-HSA-1566977", "R-HSA-9927432", "R-HSA-354194", "R-MMU-354194", "R-HSA-9679191", "R-MMU-1236973", "R-RNO-9013423", "R-HSA-9830674", "R-HSA-5663220", "R-MMU-9013149", "R-RNO-3000170", "R-HSA-202733", "R-MMU-2129379"], "pathways": ["R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-3000157:r:Laminin interactions", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-445355:r:Smooth Muscle Contraction", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-9634597:r:GPER1 signaling", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-210990:r:PECAM1 interactions", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-1566977:r:Fibronectin matrix formation", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-BTA-1566948:r:Elastic fibre formation", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-1566948:r:Elastic fibre formation", "R-HSA-447041:r:CHL1 interactions", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-114608:r:Platelet degranulation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-1566948:r:Elastic fibre formation", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-RNO-114608:r:Platelet degranulation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-354192:r:Integrin signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-354192:r:Integrin signaling", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-210991:r:Basigin interactions", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR040623": {"description": "26S proteasome regulatory subunit RPN2, C-terminal", 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"R-DDI-4641258", "R-RNO-8951664", "R-RNO-9954709", "R-HSA-180534", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-CEL-8948751", "R-MMU-5687128", "R-RNO-5358346", "R-MMU-9766229", "R-DME-5358346", "R-RNO-69481", "R-RNO-6798695", "R-DDI-187577", "R-HSA-174154", "R-DME-69017", "R-RNO-9932298", "R-RNO-1234176", "R-RNO-5632684", "R-MMU-187577", "R-RNO-5676590", "R-DDI-382556", "R-HSA-68949", "R-HSA-5610785", "R-HSA-2467813", "R-DME-983168", "R-DME-187577", "R-MMU-8852276", "R-SCE-6798695", "R-RNO-174178", "R-RNO-69601", "R-CEL-9907900", "R-MMU-68949", "R-HSA-9824272", "R-MMU-174178", "R-CEL-983168", "R-MMU-349425", "R-MMU-8939236", "R-CEL-8854050", "R-HSA-9907900", "R-DME-350562", "R-DME-174084", "R-RNO-4641257", "R-DME-9907900", "R-DDI-69601", "R-CEL-75815", "R-DDI-5689603", "R-DDI-2467813", "R-DME-9929491", "R-RNO-349425", "R-MMU-9762114", "R-HSA-9762114", "R-MMU-195253", "R-DDI-5689880", "R-MMU-202424", "R-HSA-195253", "R-DME-5632684", "R-MMU-382556", "R-HSA-5610780", "R-DME-209360", "R-DDI-5687128", "R-CEL-9755511", "R-DME-6798695", "R-DDI-9907900", "R-RNO-9755511", "R-SCE-1236978", "R-RNO-75815", "R-DME-8939236", "R-MMU-1169091", "R-DME-174184", "R-DME-432626", "R-RNO-174113", "R-MMU-5607761", "R-MMU-5676590", "R-DME-8854050", "R-CEL-5689880", "R-HSA-8939902", "R-MMU-174184", "R-RNO-187577", "R-RNO-68867", "R-MMU-8939902", "R-RNO-350562", "R-DME-174178", "R-RNO-9762114", "R-DME-9932298", "R-DME-9020702", "R-RNO-69017", "R-RNO-195253", "R-CEL-9762114", "R-HSA-8939236", "R-CEL-8951664", "R-SPO-350562", "R-HSA-5358346", "R-DDI-8854050", "R-HSA-6798695", "R-DME-5689880", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-MMU-5607764", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-DME-8951664", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-HSA-202424", "R-DDI-1236978", "R-DDI-8951664", "R-DDI-5632684", "R-MMU-8951664", "R-DME-8939902", "R-RNO-174154", "R-CEL-382556", "R-CEL-5689603", "R-HSA-4641257", "R-RNO-202424", "R-MMU-9929491", "R-MMU-9929356", "R-HSA-174113", "R-DME-4608870", "R-RNO-5607761", "R-SCE-5668541", "R-RNO-9929356", "R-DDI-174154", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-HSA-69481", "R-DME-9762114", "R-CEL-4641258", "R-DDI-5658442", "R-DDI-8948751", "R-HSA-8941858", "R-HSA-5678895", "R-HSA-9755511", "R-RNO-9931269", "R-DME-202424", "R-CEL-9929491", "R-HSA-4641258", "R-RNO-8939236", "R-SPO-5689603", "R-DME-9755511", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-HSA-1169091", "R-CEL-69017", "R-HSA-4608870", "R-HSA-5658442", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-MMU-6798695", "R-DME-5610785", "R-RNO-2467813", "R-HSA-5689603", "R-DME-5607764", "R-RNO-983168", "R-DME-209406", "R-DME-2871837", "R-DME-450408", "R-DME-8941858", "R-SPO-6798695", "R-MMU-5610780", "R-HSA-187577", "R-DME-1169091", "R-DME-9954709", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-MMU-350562", "R-DDI-75815", "R-MMU-69601", "R-DME-195253", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-DME-5689603", "R-MMU-5658442", "R-RNO-8852276", "R-MMU-5689603", "R-HSA-174084", "R-DME-5607761", "R-DME-216167", "R-MMU-4608870", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-DDI-69017", "R-RNO-9907900", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-RNO-9929491", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-DME-538864", "R-SCE-9907900", "R-DDI-983168", "R-HSA-5668541", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-RNO-5607764", "R-RNO-8941858", "R-DDI-349425", "R-RNO-1169091", "R-RNO-5658442", "R-HSA-5687128", "R-HSA-69017", "R-RNO-9766229", "R-RNO-5610785", "R-MMU-983168", "R-DDI-450408", "R-DME-432395", "R-CEL-350562", "R-MMU-1236978", "R-HSA-350562", "R-DDI-174178", "R-CEL-4641257", "R-DME-68867", "R-RNO-2871837"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-2467813:r:Separation of Sister Chromatids", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-4641258:r:Degradation of DVL", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-4641258:r:Degradation of DVL", "R-RNO-8951664:r:Neddylation", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9766229:r:Degradation of CDH1", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-RNO-69481:r:G2/M Checkpoints", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-983168:r:Antigen 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stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR040638": {"description": "N-terminal PilZ-like domain", "go_ids": [], "go_terms": [], "name": "PilZN1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040639": {"description": "Alpha-2-macroglobulin, MG1 domain", "go_ids": [], "go_terms": [], "name": "A2MG_MG1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040640": {"description": "Myosin X, N-terminal SH3 domain", "go_ids": [], "go_terms": [], "name": "MyoX_N_SH3", "pathway_ids": ["R-HSA-2029482", "R-HSA-373752", "R-HSA-9664422", "R-MMU-2029482", "R-RNO-2029482"], "pathways": ["R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation"], "type": "Domain"}, "IPR040641": {"description": "E3 ubiquitin-protein ligase RNF31, PUB domain", "go_ids": [], "go_terms": [], "name": "RNF31_PUB", "pathway_ids": ["R-MMU-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357956", "R-HSA-5357786", "R-MMU-5357905"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling"], "type": "Domain"}, "IPR040642": {"description": "Histidine kinase receptor ArcB, transmembrane domain", "go_ids": [], "go_terms": [], "name": "HKR_ArcB_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040643": {"description": "Murine leukemia virus integrase, C-terminal", "go_ids": [], "go_terms": [], "name": "MLVIN_C", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR040644": {"description": "Hydrogen maturase F, tetramerization domain", "go_ids": [], "go_terms": [], "name": "HydF_tetramer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040645": {"description": "Neurabin-1/2, PDZ domain", "go_ids": [], "go_terms": [], "name": "Neurabin-1/2_PDZ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040646": {"description": "Fanconi anemia core complex-associated protein 24, pseudonuclease domain", "go_ids": [], "go_terms": [], "name": "PND", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-BTA-9833482", "R-BTA-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-BTA-9833482:r:PKR-mediated signaling", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR040647": {"description": "SPIN-DOC-like, zinc-finger", "go_ids": [], "go_terms": [], "name": "SPIN-DOC_Znf-C2H2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040648": {"description": "HMG domain-containing protein 3, CxC4 like cysteine cluster", "go_ids": [], "go_terms": [], "name": "HMGXB3_CxC4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040649": {"description": "Bacterial HORMA domain", "go_ids": [], "go_terms": [], "name": "Bact_HORMA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040650": {"description": "Cell division control protein 13, OB2 domain", "go_ids": [], "go_terms": [], "name": "Cdc13_OB2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040651": {"description": "Large polyvalent protein-associated domain 5", "go_ids": [], "go_terms": [], "name": "LPD5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040652": {"description": "Cry35Ab1, HTH C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cry35Ab1_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040653": {"description": "Csd3, N-terminal", "go_ids": [], "go_terms": [], "name": "Csd3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040654": {"description": "LasR-specific antiactivator QslA", "go_ids": [], "go_terms": [], "name": "QslA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040655": {"description": "TIAM1, CC-Ex domain", "go_ids": [], "go_terms": [], "name": "TIAM1_CC-Ex", "pathway_ids": ["R-HSA-1989781", "R-DME-9013149", "R-HSA-193648", "R-DME-8980692", "R-MMU-3928665", "R-MMU-8980692", "R-DME-3928662", "R-HSA-416482", "R-MMU-9013148", "R-MMU-9013404", "R-HSA-3928662", "R-HSA-9013404", "R-HSA-9013423", "R-MMU-9013423", "R-HSA-9013149", "R-DME-9013148", "R-HSA-8980692", "R-HSA-3928665", "R-DME-193648", "R-MMU-416482", "R-DME-416482", "R-HSA-9013148", "R-MMU-3928662", "R-DME-3928665", "R-MMU-193648", "R-MMU-9013149", "R-HSA-9032845", "R-DME-9013423"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-193648:r:NRAGE signals death through JNK", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-DME-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR040656": {"description": "Cas9, WED domain", "go_ids": [], "go_terms": [], "name": "Cas9_WED_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040657": {"description": "GshAB, ATP-grasp-like domain", "go_ids": [], "go_terms": [], "name": "GshAB_ATP-grasp", "pathway_ids": ["PWY-8043", "PWY-6840", "PWY-7255"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "PWY-6840:t:homoglutathione biosynthesis", "PWY-7255:t:ergothioneine biosynthesis I (bacteria)"], "type": "Domain"}, "IPR040658": {"description": "SipA, vinculin binding site", "go_ids": [], "go_terms": [], "name": "SipA_VBS", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR040659": {"description": "Phenylalanine--tRNA ligase beta subunit, B1 domain", "go_ids": [], "go_terms": [], "name": "PhetRS_B1", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR040660": {"description": "N-formyltransferase dimerization C-terminal domain", "go_ids": [], "go_terms": [], "name": "N_formyltrans_C", "pathway_ids": ["PWY-7564", "PWY-8374"], "pathways": ["PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8374:t:antimycin biosynthesis"], "type": "Domain"}, "IPR040661": {"description": "Leucine zipper with capping helix domain", "go_ids": [], "go_terms": [], "name": "LZ3wCH", "pathway_ids": ["R-HSA-912446"], "pathways": ["R-HSA-912446:r:Meiotic recombination"], "type": "Domain"}, "IPR040662": {"description": "Transcription factor Tfb2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tfb2_C", "pathway_ids": ["R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-MMU-113418", "R-HSA-427413", "R-DDI-73776", "R-DDI-6782210", "R-SPO-6781823", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-MMU-5696395", "R-SPO-5696395", "R-SPO-76042", "R-HSA-167246", "R-HSA-73776", "R-DDI-674695", "R-HSA-75953", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-MMU-73779", "R-MMU-76042", "R-SPO-75953", "R-SPO-113418", "R-DDI-73779", "R-DDI-6781823", "R-DDI-72086", "R-MMU-674695", "R-SCE-76042", "R-HSA-167161", "R-HSA-167200", "R-SCE-674695", "R-DDI-77075", "R-HSA-167160", "R-HSA-5696395", "R-SPO-73779", "R-MMU-73772", "R-MMU-72086", "R-MMU-6782210", "R-DDI-113418", "R-SPO-73776", "R-SCE-6782135", "R-SCE-73776", "R-DDI-6782135", "R-MMU-73762", "R-DDI-5696395", "R-HSA-6781827", "R-MMU-6782135", "R-HSA-72086", "R-HSA-167162", "R-MMU-6781823", "R-DDI-73772", "R-HSA-167152", "R-DDI-6796648", "R-HSA-113418", "R-HSA-6782210", "R-MMU-73776", "R-DDI-76042", "R-SCE-6782210", "R-HSA-167172", "R-MMU-5696400", "R-SCE-6796648", "R-SCE-73779", "R-SPO-77075", "R-MMU-6796648", "R-SCE-113418", "R-SCE-72086", "R-MMU-73863", "R-SCE-6781823", "R-HSA-6782135", "R-HSA-73762", "R-HSA-73863", "R-SPO-73772", "R-MMU-77075", "R-SPO-5696400", "R-SCE-77075", "R-SPO-6782210", "R-HSA-75955", "R-HSA-5696400", "R-DDI-75953", "R-SPO-6782135", "R-HSA-76042", "R-SCE-73772", "R-HSA-674695", "R-HSA-112382", "R-HSA-73779"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-72086:r:mRNA Capping", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-72086:r:mRNA Capping", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Domain"}, "IPR040663": {"description": "DNA polymerase delta subunit, OB-fold domain", "go_ids": [], "go_terms": [], "name": "DNA_pol_D_N", "pathway_ids": ["R-BTA-174411", "R-BTA-5358606", "R-CEL-69091", "R-RNO-174437", "R-HSA-174414", "R-SPO-5656169", "R-MMU-174417", "R-HSA-5696397", "R-CEL-69166", "R-RNO-110314", "R-MMU-110314", "R-RNO-69183", "R-HSA-174417", "R-CEL-110314", "R-MMU-174414", "R-RNO-5696397", "R-SPO-69091", "R-DME-69183", "R-MMU-174437", "R-BTA-5696397", "R-RNO-5656169", "R-BTA-110314", "R-MMU-5358606", "R-BTA-69183", "R-MMU-5358565", "R-SPO-69166", "R-RNO-6782210", "R-SCE-69183", "R-MMU-5651801", "R-BTA-6782135", "R-CEL-6782210", "R-MMU-69183", "R-CEL-6782135", "R-SPO-110314", "R-SCE-69166", "R-BTA-6782210", "R-MMU-6782210", "R-CEL-5651801", "R-MMU-5696397", "R-MMU-174411", "R-HSA-110314", "R-SPO-5651801", "R-RNO-174414", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-5358606", "R-BTA-174437", "R-BTA-174417", "R-RNO-69166", "R-CEL-69183", "R-BTA-5651801", "R-BTA-69166", "R-HSA-6782210", "R-CEL-5656169", "R-BTA-5656169", "R-BTA-5696400", "R-HSA-5656169", "R-RNO-174411", "R-MMU-5696400", "R-SPO-5696397", "R-RNO-5358606", "R-RNO-5358565", "R-RNO-6782135", "R-SPO-69183", "R-MMU-5656169", "R-BTA-69091", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-174411", "R-HSA-5651801", "R-HSA-69166", "R-CEL-5696397", "R-RNO-69091", "R-RNO-5685942", "R-SPO-5696400", "R-BTA-5358565", "R-SPO-6782210", "R-MMU-69166", "R-HSA-69183", "R-BTA-5685942", "R-RNO-5696400", "R-RNO-174417", "R-HSA-5696400", "R-HSA-5358565", "R-HSA-69091", "R-BTA-174414", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-CEL-69091:r:Polymerase switching", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SPO-69091:r:Polymerase switching", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-BTA-69183:r:Processive synthesis on the lagging strand", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-CEL-6782135:r:Dual incision in TC-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-BTA-69091:r:Polymerase switching", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-69091:r:Polymerase switching", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-69091:r:Polymerase switching", "R-BTA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Domain"}, "IPR040664": {"description": "AFL, C-terminal", "go_ids": [], "go_terms": [], "name": "AFL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040665": {"description": "Tyrosine kinase receptor A, transmembrane domain", "go_ids": [], "go_terms": [], "name": "TrkA_TMD", "pathway_ids": ["R-HSA-177504", "R-HSA-167044", "R-HSA-187024", "R-HSA-187042", "R-HSA-187706", "R-HSA-170968", "R-HSA-167021", "R-HSA-198745", "R-HSA-198203", "R-HSA-170984"], "pathways": ["R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-167044:r:Signalling to RAS", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-187042:r:TRKA activation by NGF", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-167021:r:PLC-gamma1 signalling", "R-HSA-198745:r:Signalling to STAT3", "R-HSA-198203:r:PI3K/AKT activation", "R-HSA-170984:r:ARMS-mediated activation"], "type": "Domain"}, "IPR040666": {"description": "Atg29, N-terminal", "go_ids": [], "go_terms": [], "name": "Atg29_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040667": {"description": "Tyrosine-protein kinase receptor Ret, cadherin like domain 3", "go_ids": [], "go_terms": [], "name": "Ret_CLD3", "pathway_ids": ["R-HSA-9830674", "R-HSA-8853659", "R-RNO-8853659", "R-HSA-9830364", "R-MMU-8853659", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-9768919", "R-HSA-5673001"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8853659:r:RET signaling", "R-RNO-8853659:r:RET signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-MMU-8853659:r:RET signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Domain"}, "IPR040668": {"description": "TraI, 2B/2B-like domain", "go_ids": [], "go_terms": [], "name": "TraI_2B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040669": {"description": "Agarase, CBM-like domain", "go_ids": [], "go_terms": [], "name": "Agarase_CBM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040670": {"description": "Protein of unknown function DUF5556", "go_ids": [], "go_terms": [], "name": "DUF5556", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040671": {"description": "Pullulanase, N2 domain", "go_ids": [], "go_terms": [], "name": "Pullulanase_N2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040672": {"description": "Large polyvalent protein associated domain 34", "go_ids": [], "go_terms": [], "name": "LPD34", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040673": {"description": "CCDC81, HU domain 2", "go_ids": [], "go_terms": [], "name": "CCDC81_HU_dom_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040674": {"description": "PvuRts1 I-like, SET and RING associated domain", "go_ids": [], "go_terms": [], "name": "PvuRts1I-like_SRA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040675": {"description": "E3 ubiquitin-protein ligase AMFR, Ube2g2-binding region", "go_ids": [], "go_terms": [], "name": "AMFR_Ube2g2-bd", "pathway_ids": ["R-HSA-901032", "R-HSA-532668", "R-MMU-532668", "R-DRE-532668"], "pathways": ["R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "type": "Domain"}, "IPR040676": {"description": "Domain of unknown function DUF5641", "go_ids": [], "go_terms": [], "name": "DUF5641", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040677": {"description": "Large polyvalent protein-associated domain 7", "go_ids": [], "go_terms": [], "name": "LPD7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040678": {"description": "AbrB, C-terminal", "go_ids": [], "go_terms": [], "name": "AbrB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040679": {"description": "PTX/LNS-Like (PLL) domain", "go_ids": [], "go_terms": [], "name": "PLL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040680": {"description": "Domain of unknown function DUF5643", "go_ids": [], "go_terms": [], "name": "DUF5643", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040681": {"description": "Cilia- and flagella-associated protein HOATZ-like", "go_ids": ["GO:0060271"], "go_terms": ["GO:0060271:cilium assembly:P"], "name": "HOATZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040682": {"description": "HscB, tetracysteine metal binding motif", "go_ids": [], "go_terms": [], "name": "HscB_4_cys", "pathway_ids": ["R-HSA-1362409", "R-HSA-9865881", "R-HSA-1268020", "R-MMU-6799198", "R-HSA-6799198", "R-MMU-1362409", "R-MMU-1268020", "R-MMU-9865881"], "pathways": ["R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9865881:r:Complex III assembly", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-1268020:r:Mitochondrial protein import", "R-MMU-9865881:r:Complex III assembly"], "type": "Domain"}, "IPR040683": {"description": "Surface adhesin CshA, non-repetitive domain 2", "go_ids": [], "go_terms": [], "name": "CshA_NR2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040684": {"description": "5-hmdU DNA kinase, helical domain", "go_ids": [], "go_terms": [], "name": "HMUDK_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040685": {"description": "Annexin-like domain", "go_ids": [], "go_terms": [], "name": "Annexin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040686": {"description": "Phosphoribosylaminoimidazole carboxylase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PurK_C", "pathway_ids": ["PWY-6123", "PWY-7234"], "pathways": ["PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-7234:t:inosine-5'-phosphate biosynthesis III"], "type": "Domain"}, "IPR040687": {"description": "Protein of unknown function DUF5586", "go_ids": [], "go_terms": [], "name": "DUF5586", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040688": {"description": "SMODS and SLOG-associating 2TM effector domain 2", "go_ids": [], "go_terms": [], "name": "SLATT_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040689": {"description": "SUVR5, C2H2-type Zinc finger, 3 repeats", "go_ids": [], "go_terms": [], "name": "SUVR5_Znf-C2H2_3rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040690": {"description": "FtsX, extracellular domain", "go_ids": [], "go_terms": [], "name": "FtsX_ECD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040691": {"description": "PexRD2, WYL domain", "go_ids": [], "go_terms": [], "name": "PexRD2_WYL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040692": {"description": "UGGT, thioredoxin-like domain 3", "go_ids": [], "go_terms": [], "name": "UGGT_TRXL_3", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-901032"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)"], "type": "Domain"}, "IPR040693": {"description": "UGGT, thioredoxin-like domain 1", "go_ids": [], "go_terms": [], "name": "UGGT_TRXL_1", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-901032"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)"], "type": "Domain"}, "IPR040694": {"description": "UGGT, thioredoxin-like domain 2", "go_ids": [], "go_terms": [], "name": "UGGT_TRXL_2", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-901032"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)"], "type": "Domain"}, "IPR040695": {"description": "EcpB, C-terminal", "go_ids": [], "go_terms": [], "name": "EcpB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040696": {"description": "Large polyvalent protein associated domain 23", "go_ids": [], "go_terms": [], "name": "LPD23", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040697": {"description": "Pullulanase, N1 domain", "go_ids": [], "go_terms": [], "name": "PulA_N1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040698": {"description": "Hydrazine synthase alpha subunit, middle domain", "go_ids": [], "go_terms": [], "name": "HZS_alpha_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040699": {"description": "DNA 3'-5' translocase XPB, damage recognition domain", "go_ids": [], "go_terms": [], "name": "XPB_DRD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040700": {"description": "ZNRF-3, ectodomain", "go_ids": [], "go_terms": [], "name": "ZNRF-3_ecto", "pathway_ids": ["R-HSA-5340588", "R-XTR-4641263", "R-MMU-4641263", "R-HSA-4641263", "R-DRE-4641263", "PWY-7511"], "pathways": ["R-HSA-5340588:r:Signaling by RNF43 mutants", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-DRE-4641263:r:Regulation of FZD by ubiquitination", "PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR040701": {"description": "Ribosome hibernation factor Rv2629-like, middle domain", "go_ids": [], "go_terms": [], "name": "Rv2629-like_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040703": {"description": "Limiting CO2-inducible protein B/C, beta carbonyic anhydrase domain", "go_ids": [], "go_terms": [], "name": "LCIB/C_CA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040704": {"description": "HEPN, AbiU2-like", "go_ids": [], "go_terms": [], "name": "HEPN_AbiU2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040706": {"description": "MYST, zinc finger domain", "go_ids": [], "go_terms": [], "name": "Zf-MYST", "pathway_ids": ["R-HSA-5693616", "R-RNO-5693565", "R-MMU-6804756", "R-HSA-5693565", "R-MMU-5693616", "R-RNO-9018519", "R-MMU-5685938", "R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-RNO-9772755", "R-MMU-5693568", "R-HSA-9018519", "R-DME-5693607", "R-DME-9772755", "R-RNO-5693579", "R-MMU-2559586", "R-HSA-69473", "R-DME-9018519", "R-RNO-5693607", "R-RNO-5693571", "R-RNO-69473", "R-MMU-9018519", "R-CEL-6804758", "R-RNO-6804758", "R-HSA-6804756", "R-HSA-9704331", "R-RNO-5693568", "R-MMU-6804758", "R-DME-2559586", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-MMU-5693571", "R-HSA-2559586", "R-HSA-5685942", "R-HSA-9772755", "R-HSA-9704646", "R-DME-5693565", "R-CEL-201722", "R-RNO-5693548", "R-SCE-6804758", "R-MMU-5693565", "R-HSA-6804758", "R-RNO-5685938", "R-RNO-6804756", "R-MMU-9772755", "R-MMU-5693579", "R-CEL-3214847", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-MMU-3214847", "R-RNO-2559586", "R-MMU-5693548", "R-MMU-5685942", "R-HSA-9709603", "R-DME-201722", "R-RNO-5685942", "R-HSA-201722", "R-HSA-5693571", "R-RNO-3214847", "R-DME-3214847", "R-SPO-6804758", "R-HSA-9733709", "R-CEL-9018519", "R-HSA-3214847", "R-DME-5693548", "R-HSA-5693579"], "pathways": ["R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-5693607:r:Processing of DNA double-strand break ends", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-CEL-3214847:r:HATs acetylate histones", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-3214847:r:HATs acetylate histones", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9733709:r:Cardiogenesis", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange"], "type": "Domain"}, "IPR040707": {"description": "Phosphoribosylformylglycinamidine synthase, N-terminal", "go_ids": [], "go_terms": [], "name": "FGAR-AT_N", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-MMU-73817", "R-CEL-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis"], "type": "Domain"}, "IPR040708": {"description": "Domain of of unknown function DUF5636", "go_ids": [], "go_terms": [], "name": "DUF5636", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040709": {"description": "Importin 13, repeat 1", "go_ids": [], "go_terms": [], "name": "Importin_rep_1", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040711": {"description": "Immunomodulating metalloprotease, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ImpA_N_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040712": {"description": "Phosphofructokinase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Pfk_N", "pathway_ids": ["PWY-5484", "PWY-1861", "PWY-1042", "PWY-7385", "R-SCE-6798695", "R-SPO-6798695", "R-SPO-70171", "R-SCE-70171"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-1042:t:glycolysis IV", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "R-SCE-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-70171:r:Glycolysis", "R-SCE-70171:r:Glycolysis"], "type": "Domain"}, "IPR040713": {"description": "Domain of unknown function DUF5611", "go_ids": [], "go_terms": [], "name": "DUF5611", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040714": {"description": "RAP80, N-terminal", "go_ids": [], "go_terms": [], "name": "RAP80_UIM", "pathway_ids": ["R-MMU-69473", "R-HSA-5689901", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-69473", "R-RNO-5693565", "R-MMU-5689901", "R-RNO-5693607", "R-HSA-5693565", "R-RNO-5689901", "R-RNO-5693571", "R-MMU-5693571", "R-RNO-69473", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5689901:r:Metalloprotease DUBs", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR040715": {"description": "Kinetoplastid DICER, KptA ADP-ribosyltransferase domain", "go_ids": [], "go_terms": [], "name": "KptA_kDICER", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040716": {"description": "Outer-membrane lipoprotein Wza, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Wza_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040717": {"description": "P-loop nucleotide kinase 3", "go_ids": [], "go_terms": [], "name": "Ploop_nt_kinase3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040718": {"description": "LnmK, N-terminal", "go_ids": [], "go_terms": [], "name": "LnmK_N_HDF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040719": {"description": "Domain of unknown function DUF5597", "go_ids": [], "go_terms": [], "name": "DUF5597", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040720": {"description": "Glycosyl hydrolase family 81, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GH81_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040721": {"description": "Protein of unknown function DUF5520", "go_ids": [], "go_terms": [], "name": "DUF5520", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040722": {"description": "Hit1, C-terminal", "go_ids": [], "go_terms": [], "name": "Hit1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040723": {"description": "Cytosolic phospholipases A2, C2-domain", "go_ids": [], "go_terms": [], "name": "cPLA2_C2", "pathway_ids": ["PWY-8411", "PWY-8051", "PWY-7783", "PWY-7416", "PWY-8398", "PWY-7417", "PWY-8400", "PWY-8399", "PWY-7409", "PWY-6803", "PWY-8395", "PWY-8356", "PWY-8357", "PWY-8355", "PWY-8396", "PWY-8413", "PWY-8397", "PWY-8053", "PWY-8412", "PWY-8410", "R-HSA-381038", "R-HSA-1483166", "R-MMU-1482839", "R-HSA-1482925", "R-MMU-1483115", "R-HSA-1482801", "R-MMU-1483166", "R-HSA-1482922", "R-MMU-1482922", "R-HSA-1482839", "R-MMU-1482788", "R-MMU-1482925", "R-MMU-1482801", "R-HSA-1483115", "R-HSA-1482788"], "pathways": ["PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-8051:t:anandamide biosynthesis I", "PWY-7783:t:plasmalogen degradation", "PWY-7416:t:phospholipid remodeling (phosphatidylcholine, yeast)", "PWY-8398:t:alpha-linolenate metabolites biosynthesis", "PWY-7417:t:phospholipid remodeling (phosphatidate, yeast)", "PWY-8400:t:docosahexaenoate metabolites biosynthesis", "PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-7409:t:phospholipid remodeling (phosphatidylethanolamine, yeast)", "PWY-6803:t:phosphatidylcholine acyl editing", "PWY-8395:t:linoleate metabolites biosynthesis", "PWY-8356:t:maresin biosynthesis", "PWY-8357:t:protectin biosynthesis", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-8413:t:representative whole plasma EPA-derived icosanoids", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-8412:t:representative whole plasma DHA-derived icosanoids", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-1483166:r:Synthesis of PA", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-1482925:r:Acyl chain remodelling of PG", "R-MMU-1483115:r:Hydrolysis of LPC", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-MMU-1483166:r:Synthesis of PA", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-MMU-1482925:r:Acyl chain remodelling of PG", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-HSA-1483115:r:Hydrolysis of LPC", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Domain"}, "IPR040724": {"description": "PheRS, DNA binding domain 1", "go_ids": [], "go_terms": [], "name": "PheRS_DBD1", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR040725": {"description": "PheRS, DNA binding domain 3", "go_ids": [], "go_terms": [], "name": "PheRS_DBD3", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR040726": {"description": "Halobacterial output domain 2", "go_ids": [], "go_terms": [], "name": "HalOD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040727": {"description": "Nicotinate phosphoribosyltransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NAPRTase_N", "pathway_ids": ["PWY-5381", "R-MMU-196807", "R-DDI-6798695", "R-HSA-6798695", "R-DRE-6798695", "R-DME-196807", "R-DME-6798695", "R-DRE-196807", "R-CEL-6798695", "R-CEL-196807", "R-HSA-196807", "R-MMU-6798695", "R-DDI-196807", "R-RNO-6798695", "R-RNO-196807"], "pathways": ["PWY-5381:t:NAD salvage (plants)", "R-MMU-196807:r:Nicotinate metabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-196807:r:Nicotinate metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-DRE-196807:r:Nicotinate metabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-196807:r:Nicotinate metabolism"], "type": "Domain"}, "IPR040728": {"description": "Domain of unknown function DUF5635", "go_ids": [], "go_terms": [], "name": "DUF5635", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040729": {"description": "Kazal-type serine protease inhibitor domain", "go_ids": [], "go_terms": [], "name": "Kazal_3", "pathway_ids": ["R-HSA-977606", "R-MMU-166665", "R-HSA-166665", "R-MMU-977606"], "pathways": ["R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-166665:r:Terminal pathway of complement", "R-HSA-166665:r:Terminal pathway of complement", "R-MMU-977606:r:Regulation of Complement cascade"], "type": "Domain"}, "IPR040730": {"description": "Hexapeptide repeat including loop", "go_ids": [], "go_terms": [], "name": "Hexapep_loop", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040731": {"description": "Metal-independent restriction enzyme BfiI, DNA binding domain", "go_ids": [], "go_terms": [], "name": "BfiI_DBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040733": {"description": "Zyg-1, polo box domain 1", "go_ids": [], "go_terms": [], "name": "Zyg-1_PB1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040734": {"description": "Zyg-1, polo box domain 2", "go_ids": [], "go_terms": [], "name": "Zyg-1_PB2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040735": {"description": "Protein of unknown function DUF5583", "go_ids": [], "go_terms": [], "name": "DUF5583", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040736": {"description": "Mex67, RNA recognition motif", "go_ids": [], "go_terms": [], "name": "Mex67_RRM", "pathway_ids": ["R-SPO-159236", "R-SPO-159227", "R-SPO-159231"], "pathways": ["R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript"], "type": "Domain"}, "IPR040737": {"description": "Domain of unknown function DUF5638", "go_ids": [], "go_terms": [], "name": "DUF5638", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040738": {"description": "Large polyvalent protein associated domain 22", "go_ids": [], "go_terms": [], "name": "LPD22", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040739": {"description": "RlmM ferredoxin-like domain", "go_ids": [], "go_terms": [], "name": "RlmM_FDX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040740": {"description": "MglB-2, periplasmic binding protein domain", "go_ids": [], "go_terms": [], "name": "MglB-2_Peripla_BP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040741": {"description": "Amino acid:DNA transferase", "go_ids": [], "go_terms": [], "name": "ADDT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040742": {"description": "Peptidoglycan hydrolase LytB, WW-like domain", "go_ids": [], "go_terms": [], "name": "LytB_WW-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040743": {"description": "DNA methylase N-terminal domain", "go_ids": [], "go_terms": [], "name": "DNA_meth_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040744": {"description": "Npun R1517", "go_ids": [], "go_terms": [], "name": "Npun_R1517", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040745": {"description": "Ankyrin, UPA domain", "go_ids": [], "go_terms": [], "name": "Ankyrin_UPA", "pathway_ids": ["R-HSA-447043", "R-MMU-445095", "R-HSA-445095", "R-HSA-6807878", "R-MMU-6807878", "R-HSA-9768727", "R-HSA-447038", "R-MMU-447043", "R-HSA-447041"], "pathways": ["R-HSA-447043:r:Neurofascin interactions", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-447038:r:NrCAM interactions", "R-MMU-447043:r:Neurofascin interactions", "R-HSA-447041:r:CHL1 interactions"], "type": "Domain"}, "IPR040746": {"description": "THO1_MOS11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "THO1_MOS11_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040747": {"description": "BILBO1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BILBO1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040748": {"description": "HP0268", "go_ids": [], "go_terms": [], "name": "HP0268", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040749": {"description": "BRCC36, C-terminal helical domain", "go_ids": [], "go_terms": [], "name": "BRCC36_C", "pathway_ids": ["R-HSA-5689901", "R-BTA-69473", "R-HSA-69473", "R-RNO-5693565", "R-MMU-5689901", "R-RNO-5693607", "R-BTA-5693565", "R-HSA-5693565", "R-RNO-5689901", "R-RNO-5693571", "R-RNO-69473", "R-XTR-5689901", "R-MMU-5693565", "R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-BTA-5693607", "R-BTA-5693571", "R-MMU-5693571", "R-BTA-5689901", "R-MMU-5693607"], "pathways": ["R-HSA-5689901:r:Metalloprotease DUBs", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5689901:r:Metalloprotease DUBs", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-XTR-5689901:r:Metalloprotease DUBs", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-BTA-5689901:r:Metalloprotease DUBs", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Domain"}, "IPR040750": {"description": "eIF3 subunit M, C-terminal helix domain", "go_ids": [], "go_terms": [], "name": "eIF3m_C_helix", "pathway_ids": ["R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-DME-72649", "R-HSA-156827", "R-XTR-72702", "R-GGA-72702", "R-MMU-72649", "R-HSA-72695", "R-MMU-72706", "R-SPO-72689", "R-XTR-72695", "R-MMU-72695", "R-DRE-156827", "R-DME-72695", "R-MMU-72702", "R-DRE-72695", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-XTR-156827", "R-DME-72689", "R-HSA-72706", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-GGA-72649", "R-DRE-72649", "R-DRE-72702", "R-DRE-72689", "R-SPO-156827", "R-DME-72702", "R-GGA-72695", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": ["R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-GGA-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Domain"}, "IPR040751": {"description": "S-layer protein SbsC, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SbsC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040752": {"description": "DNA mismatch repair protein HSM3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HSM3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040753": {"description": "Domain of unknown function DUF5620", "go_ids": [], "go_terms": [], "name": "DUF5620", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040754": {"description": "Pre ATP-grasp domain", "go_ids": [], "go_terms": [], "name": "PreAtp-grasp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040755": {"description": "Interleukin receptor mimic protein A", "go_ids": [], "go_terms": [], "name": "IrmA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040756": {"description": "Peptidase M61, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Peptidase_M61_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040757": {"description": "Endoribonuclease Regnase 1/ZC3H12, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Regnase_1/ZC3H12_C", "pathway_ids": ["R-HSA-9764302"], "pathways": ["R-HSA-9764302:r:Regulation of CDH19 Expression and Function"], "type": "Domain"}, "IPR040758": {"description": "Release factor glutamine methyltransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PrmC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040759": {"description": "Regulator of G-protein signalling, DHEX domain", "go_ids": [], "go_terms": [], "name": "RGS_DHEX", "pathway_ids": ["R-BTA-418594", "R-HSA-418594", "R-HSA-2514859", "R-MMU-2514859", "R-RNO-6814122", "R-HSA-6814122", "R-RNO-2514859", "R-BTA-6814122", "R-CEL-418594", "R-MMU-418594", "R-CEL-6814122", "R-RNO-418594", "R-MMU-6814122"], "pathways": ["R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-418594:r:G alpha (i) signalling events", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-418594:r:G alpha (i) signalling events", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Domain"}, "IPR040760": {"description": "Testis-specific expressed protein 55", "go_ids": [], "go_terms": [], "name": "Tex55", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040761": {"description": "Tle cognate immunity protein 4, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Tli4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040763": {"description": "Ribonucleotide reductase, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "RNR_alpha_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040764": {"description": "Conserved virulence factor B-like, winged helix domain", "go_ids": [], "go_terms": [], "name": "CvfB_WH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040765": {"description": "RapA, N-terminal Tudor like domain 1", "go_ids": [], "go_terms": [], "name": "Tudor_1_RapA", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR040766": {"description": "RapA, N-terminal Tudor-like domain 2", "go_ids": [], "go_terms": [], "name": "Tudor_2_RapA", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR040767": {"description": "Diphteria toxin repressor/Iron-dependent repressor IdeR, SH3 domain", "go_ids": [], "go_terms": [], "name": "DtxR/IdeR_SH3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040768": {"description": "Vid27, PH-like domain", "go_ids": [], "go_terms": [], "name": "Vid27_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040769": {"description": "Phosphoinositide phosphatase insertion domain", "go_ids": [], "go_terms": [], "name": "PI_PP_I", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040770": {"description": "Rtt106, pleckstrin homology domain", "go_ids": [], "go_terms": [], "name": "Rtt106_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040771": {"description": "Thiolase-like protein type 1, additional C-terminal domain", "go_ids": [], "go_terms": [], "name": "TLP1_add_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040773": {"description": "26S proteasome regulatory subunit Rpn6, N-terminal", "go_ids": [], "go_terms": [], "name": "Rpn6_N", "pathway_ids": ["R-HSA-5676590", "R-DRE-1236978", 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"R-MMU-68867", "R-HSA-9929491", "R-DRE-69601", "R-DME-209461", "R-XTR-9929491", "R-XTR-75815", "R-RNO-5689880", "R-DRE-9755511", "R-DRE-5689603", "R-DME-75815", "R-DRE-350562", "R-RNO-8951664", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-MMU-5687128", "R-DRE-4608870", "R-RNO-5358346", "R-DME-5358346", "R-RNO-6798695", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-DRE-349425", "R-DRE-8939902", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-XTR-8939236", "R-MMU-8939236", "R-RNO-4641257", "R-DME-9907900", "R-XTR-5610780", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-DRE-75815", "R-RNO-349425", "R-BTA-174184", "R-MMU-9762114", "R-MMU-195253", "R-MMU-202424", "R-BTA-8939236", "R-HSA-5610780", "R-MMU-382556", "R-BTA-5632684", "R-DRE-174154", "R-DDI-5687128", "R-DME-209360", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-DME-432626", "R-XTR-8852276", "R-XTR-8951664", "R-MMU-5607761", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-XTR-174084", "R-DRE-9932298", "R-MMU-8939902", "R-XTR-9932298", "R-DME-174178", "R-XTR-382556", "R-RNO-195253", "R-HSA-8939236", "R-XTR-5676590", "R-DRE-8854050", "R-BTA-983168", "R-DDI-8854050", "R-MMU-5607764", "R-DRE-5632684", "R-DME-8951664", "R-DRE-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577"], "pathways": ["R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-5632684:r:Hedgehog 'on' state", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-XTR-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-XTR-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9907900:r:Proteasome assembly", "R-CEL-4641258:r:Degradation of DVL", "R-XTR-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DRE-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-XTR-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-XTR-9907900:r:Proteasome assembly", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5689603:r:UCH proteinases", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DRE-69481:r:G2/M Checkpoints", "R-DRE-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-XTR-4641257:r:Degradation of AXIN", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-DRE-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DRE-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-XTR-195253:r:Degradation of beta-catenin by the destruction 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"R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-DRE-5687128", "R-DRE-5689880", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DRE-174084", "R-DRE-450408", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-69601", "R-CEL-68949", "R-HSA-5687128", "R-XTR-174178", "R-DME-5632684", "R-DME-432395", "R-RNO-5658442", "R-XTR-195253", "R-RNO-5610785", "R-MMU-983168", "R-HSA-350562", "R-DDI-174178", "R-DME-68867", "R-XTR-1169091"], "pathways": ["R-DRE-4641258:r:Degradation of DVL", "R-XTR-69481:r:G2/M Checkpoints", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-XTR-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-XTR-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DRE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-XTR-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DRE-9766229:r:Degradation of CDH1", "R-DDI-4641258:r:Degradation of 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proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-DRE-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-XTR-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-XTR-9907900:r:Proteasome assembly", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5689603:r:UCH proteinases", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DRE-69481:r:G2/M Checkpoints", "R-DRE-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-XTR-4641257:r:Degradation of AXIN", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-68949:r:Orc1 removal from chromatin", "R-DRE-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DRE-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DRE-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-XTR-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-XTR-195253:r:Degradation of beta-catenin by the destruction complex", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-XTR-1169091:r:Activation of NF-kappaB in B cells"], "type": "Domain"}, "IPR040781": {"description": "Rubisco accumulation factor 1, helix turn helix domain", "go_ids": [], "go_terms": [], "name": "Raf1_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040782": {"description": "TraB/Toxin zeta-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TraB/Zeta-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040783": {"description": "Actinobacteria/chloroflexi VLRF1 release factor", "go_ids": [], "go_terms": [], "name": "VLRF1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040784": {"description": "Glycogen debranching enzyme, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GlgX_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040785": {"description": "Immune Mapped Protein 1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "IMP1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040786": {"description": "RXLR phytopathogen effector protein, WY-domain", "go_ids": [], "go_terms": [], "name": "RXLR_WY", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040787": {"description": "Cas12a, REC1 domain", "go_ids": [], "go_terms": [], "name": "Cas12a_REC1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040788": {"description": "MAE_28990/MAE_18760-like HEPN", "go_ids": [], "go_terms": [], "name": "HEPN_MAE_28990", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040789": {"description": "Large polyvalent protein-associated domain 11", "go_ids": [], "go_terms": [], "name": "LPD11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040790": {"description": "Kindlin-2, N-terminal", "go_ids": [], "go_terms": [], "name": "Kindlin_2_N", "pathway_ids": ["R-DME-9013149", "R-MMU-446353", "R-CEL-9013423", "R-DME-114608", "R-CEL-114608", "R-CEL-446353", "R-CEL-9013149", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-114608", "R-BTA-114608", "R-MMU-114608", "R-HSA-9013149", "R-HSA-446353", "R-DRE-9013149", "R-DRE-446353", "R-DME-446353", "R-MMU-9013149", "R-DME-9013423", "R-DRE-9013423"], "pathways": ["R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DME-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-CEL-446353:r:Cell-extracellular matrix interactions", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-DRE-446353:r:Cell-extracellular matrix interactions", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR040791": {"description": "Protein of unknown function DUF5555", "go_ids": [], "go_terms": [], "name": "DUF5555", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040792": {"description": "Zap1, zinc finger 2", "go_ids": [], "go_terms": [], "name": "Zap1_Znf2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040793": {"description": "CDH1/2, SANT-Helical linker 1", "go_ids": [], "go_terms": [], "name": "CDH1_2_SANT_HL1", "pathway_ids": ["PWY-7250", "R-HSA-9018519"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR040794": {"description": "Carbohydrate esterase 2, N-terminal", "go_ids": [], "go_terms": [], "name": "CE2_N", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Domain"}, "IPR040795": {"description": "Non-structural protein 2, gammacoronavirus", "go_ids": [], "go_terms": [], "name": "NSP2_gammaCoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Domain"}, "IPR040796": {"description": "CRISPR-associated endonuclease Cas9, beta-hairpin domain", "go_ids": [], "go_terms": [], "name": "Cas9_b_hairpin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040797": {"description": "ZMIZ1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ZMIZ1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040798": {"description": "Rpn9, C-terminal helix", "go_ids": [], "go_terms": [], "name": "Rpn9_C", "pathway_ids": ["R-SCE-9907900", "R-SPO-1236978", "R-SPO-6798695", "R-SPO-9907900", "R-SCE-1236978", "R-SCE-6798695", "R-SCE-5668541", "R-SCE-5689880", "R-SPO-5689603", "R-SPO-350562", "R-SPO-5689880"], "pathways": ["R-SCE-9907900:r:Proteasome assembly", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-SCE-5689880:r:Ub-specific processing proteases", "R-SPO-5689603:r:UCH proteinases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR040799": {"description": "ComR, tetratricopeptide", "go_ids": [], "go_terms": [], "name": "ComR_TPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040800": {"description": "Methyltransferase MycE, N-terminal", "go_ids": [], "go_terms": [], "name": "MycE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040801": {"description": "Ski2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ski2_N", "pathway_ids": ["R-SCE-429958", "R-HSA-429958", "R-SPO-429958", "R-HSA-390471", "R-MMU-429958"], "pathways": ["R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Domain"}, "IPR040802": {"description": "Peptidoglycan GlcNAc deacetylase, N-terminal", "go_ids": [], "go_terms": [], "name": "PgdA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040803": {"description": "Tyramine--L-glutamate ligase, pre ATP-grasp domain", "go_ids": [], "go_terms": [], "name": "MfnD_preATP-grasp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040804": {"description": "Tetracyclin repressor-like, C-terminal domain 18", "go_ids": [], "go_terms": [], "name": "TetR_C_18", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040805": {"description": "KAHRP, N-terminal", "go_ids": [], "go_terms": [], "name": "KAHRP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040806": {"description": "SpuA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SpuA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040807": {"description": "Protein of unknown function DUF5522", "go_ids": [], "go_terms": [], "name": "DUF5522", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040808": {"description": "Protein of unknown function DUF5630", "go_ids": [], "go_terms": [], "name": "DUF5630", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040809": {"description": "Large polyvalent protein associated domain 28", "go_ids": [], "go_terms": [], "name": "LPD28", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040810": {"description": "Calcium-regulated actin-bundling protein, C-terminal", "go_ids": [], "go_terms": [], "name": "F_actin_bund_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040811": {"description": "SMODS and SLOG-associating 2TM effector domain", "go_ids": [], "go_terms": [], "name": "SLATT_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040812": {"description": "RNA helicase UPF1, 1B domain", "go_ids": [], "go_terms": [], "name": "UPF1_1B_dom", "pathway_ids": ["R-HSA-975956", "R-DDI-975956", "R-SPO-975956", "R-CEL-975956", "R-DRE-975956", "R-HSA-975957", "R-SCE-975957", "R-DME-975956", "R-CEL-975957", "R-SCE-975956", "R-MMU-975957", "R-DDI-975957", "R-DRE-975957", "R-SPO-975957", "R-DME-975957", "R-MMU-975956"], "pathways": ["R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "type": "Domain"}, "IPR040813": {"description": "Small RNA 2'-O-methyltransferase Hen1, La-motif C-terminal domain", "go_ids": [], "go_terms": [], "name": "Hen1_Lam_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040814": {"description": "Activity-regulated cytoskeleton-associated protein, C-lobe", "go_ids": [], "go_terms": [], "name": "Arc_C-lobe", "pathway_ids": ["R-HSA-9031628"], "pathways": ["R-HSA-9031628:r:NGF-stimulated transcription"], "type": "Domain"}, "IPR040815": {"description": "Nas2, N-terminal", "go_ids": [], "go_terms": [], "name": "Nas2_N", "pathway_ids": ["R-SCE-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-CEL-9907900", "R-DME-9907900", "R-SPO-9907900", "R-BTA-9907900", "R-DDI-9907900"], "pathways": ["R-SCE-9907900:r:Proteasome assembly", "R-HSA-9907900:r:Proteasome assembly", "R-MMU-9907900:r:Proteasome assembly", "R-CEL-9907900:r:Proteasome assembly", "R-DME-9907900:r:Proteasome assembly", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-9907900:r:Proteasome assembly"], "type": "Domain"}, "IPR040816": {"description": "STY4199-like HEPN domain", "go_ids": [], "go_terms": [], "name": "STY4199_HEPN_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040817": {"description": "Leukemia inhibitory factor receptor, D2 domain", "go_ids": [], "go_terms": [], "name": "LIFR_D2", "pathway_ids": ["R-MMU-6788467", "R-HSA-8939247", "R-HSA-6788467", "R-RNO-6788467"], "pathways": ["R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Domain"}, "IPR040818": {"description": "Tsi6", "go_ids": [], "go_terms": [], "name": "Tsi6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040819": {"description": "Rolling Circle replication initiation protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Rol_Rep_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040820": {"description": "Secreted Novel AID/APOBEC-like Deaminase 3", "go_ids": [], "go_terms": [], "name": "SNAD3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040821": {"description": "Testis-specific protein LINC02914-like", "go_ids": [], "go_terms": [], "name": "LINC02914-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040822": {"description": "Swi6, N-terminal", "go_ids": [], "go_terms": [], "name": "Swi6_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040824": {"description": "Large polyvalent protein-associated domain 3", "go_ids": [], "go_terms": [], "name": "LPD3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040825": {"description": "FKBP26, C-terminal", "go_ids": [], "go_terms": [], "name": "FKBP26_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040826": {"description": "LA2681-like HEPN domain", "go_ids": [], "go_terms": [], "name": "HEPN_LA2681", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040827": {"description": "Arcadin 1", "go_ids": [], "go_terms": [], "name": "Arcadin_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040828": {"description": "REase associating with pPIWI, RE domain", "go_ids": [], "go_terms": [], "name": "pPIWI_RE_REase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040829": {"description": "CD-NTase-associated protein 16, NUDIX domain", "go_ids": [], "go_terms": [], "name": "Cap16_NUDIX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040830": {"description": "Bacterial archaeo-eukaryotic release factor family 8", "go_ids": [], "go_terms": [], "name": "Bact_RF_family8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040831": {"description": "YdcK Beta solenoid repeat", "go_ids": [], "go_terms": [], "name": "B_solenoid_ydck_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040832": {"description": "TTHB210-like domain", "go_ids": [], "go_terms": [], "name": "TTHB210-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040833": {"description": "Domain of unknown function DUF5631", "go_ids": [], "go_terms": [], "name": "DUF5631", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040834": {"description": "Nicking enzyme C-terminal middle helical domain", "go_ids": [], "go_terms": [], "name": "NES_C_h", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040835": {"description": "Nucleotide modification associated domain 5", "go_ids": [], "go_terms": [], "name": "Nmad5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040836": {"description": "SMODS-associated and fused to various effectors", "go_ids": [], "go_terms": [], "name": "SAVED", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040837": {"description": "Bacterial archaeo-eukaryotic release factor family 7", "go_ids": [], "go_terms": [], "name": "Bact_RF_family7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040838": {"description": "SabA, N-terminal extracellular adhesion domain", "go_ids": [], "go_terms": [], "name": "SabA_N_adhesion", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040839": {"description": "Macroglobulin domain MG4", "go_ids": [], "go_terms": [], "name": "MG4", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR040840": {"description": "Tc toxin complex TcA, C-terminal TcB-binding domain", "go_ids": [], "go_terms": [], "name": "TcA_TcB_BD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040841": {"description": "Luciferase domain", "go_ids": [], "go_terms": [], "name": "Luciferase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040842": {"description": "Sorting nexin-17/31, FERM domain", "go_ids": [], "go_terms": [], "name": "SNX17/31_FERM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040843": {"description": "Restriction enzyme adenine methylase associated", "go_ids": [], "go_terms": [], "name": "RAMA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040844": {"description": "Phosphodiesterase 4 upstream conserved regions (UCR)", "go_ids": [], "go_terms": [], "name": "PDE4_UCR", "pathway_ids": ["R-RNO-418555", "R-CEL-9860927", "R-CEL-180024", "R-DME-418555", "R-MMU-180024", "R-MMU-418555", "R-HSA-418555", "R-HSA-9860927", "R-DME-180024", "R-DME-9860927", "R-HSA-180024", "R-RNO-180024", "R-MMU-9860927", "R-CEL-418555", "R-RNO-9860927"], "pathways": ["R-RNO-418555:r:G alpha (s) signalling events", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-180024:r:DARPP-32 events", "R-DME-418555:r:G alpha (s) signalling events", "R-MMU-180024:r:DARPP-32 events", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-180024:r:DARPP-32 events", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-180024:r:DARPP-32 events", "R-RNO-180024:r:DARPP-32 events", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-418555:r:G alpha (s) signalling events", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "type": "Domain"}, "IPR040845": {"description": "Aminoarabinose transferase, C-terminal", "go_ids": [], "go_terms": [], "name": "Arnt_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040846": {"description": "ORF 12 gene product, N-terminal", "go_ids": [], "go_terms": [], "name": "ORF_12_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040847": {"description": "Mind bomb, SH3 repeat domain", "go_ids": [], "go_terms": [], "name": "SH3_15", "pathway_ids": ["PWY-7511", "R-MMU-5357786", "R-HSA-2122948", "R-HSA-2894862", "R-RNO-5357905", "R-HSA-983168", "R-HSA-5357786", "R-RNO-9931295", "R-MMU-9931295", "R-HSA-2979096", "R-HSA-5357905", "R-MMU-5357905", "R-MMU-983168", "R-HSA-2644606", "R-HSA-9013507", "R-RNO-5357786", "R-RNO-983168", "R-HSA-2691232", "R-HSA-9931295"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Domain"}, "IPR040848": {"description": "Midasin, AAA lid domain 7", "go_ids": [], "go_terms": [], "name": "AAA_lid_7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040849": {"description": "MyBP-C, tri-helix bundle domain", "go_ids": [], "go_terms": [], "name": "MyBP-C_THB", "pathway_ids": ["R-MMU-390522", "R-HSA-114608", "R-RNO-390522", "R-HSA-390522"], "pathways": ["R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-114608:r:Platelet degranulation", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-390522:r:Striated Muscle Contraction"], "type": "Domain"}, "IPR040850": {"description": "Knl1, C-terminal RWD domain", "go_ids": [], "go_terms": [], "name": "Knl1_RWD_C", "pathway_ids": ["R-HSA-606279", "R-HSA-141444", "R-HSA-5663220", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-9648025", "R-HSA-68877"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-68877:r:Mitotic Prometaphase"], "type": "Domain"}, "IPR040851": {"description": "ParB-like, C-terminal", "go_ids": [], "go_terms": [], "name": "ParB-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040852": {"description": "Cas12a, RuvC nuclease domain", "go_ids": [], "go_terms": [], "name": "RuvC_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040853": {"description": "RapA2, cadherin-like domain", "go_ids": [], "go_terms": [], "name": "RapA2_cadherin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040854": {"description": "Uncharacterized protein ZSWIM9", "go_ids": [], "go_terms": [], "name": "ZSWIM9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040855": {"description": "Origin recognition complex subunit 3, winged helix C-terminal", "go_ids": [], "go_terms": [], "name": "ORC_WH_C", "pathway_ids": ["R-DDI-68689", "R-RNO-68949", "R-SPO-176187", "R-HSA-68949", "R-SPO-68616", "R-RNO-68962", "R-MMU-68962", "R-HSA-113507", "R-HSA-68867", "R-MMU-68949", "R-RNO-176187", "R-HSA-68689", "R-SCE-68962", "R-SCE-68616", "R-HSA-68616", "R-RNO-68616", "R-DDI-68962", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949", "R-SCE-176187", "R-HSA-176187", "R-RNO-68689", "R-DDI-68616"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication"], "type": "Domain"}, "IPR040856": {"description": "Glucose import ATP-binding protein GlcV, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GlcV_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040857": {"description": "VioE domain", "go_ids": [], "go_terms": [], "name": "VioE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040858": {"description": "Rubisco accumulation factor 1, C-terminal", "go_ids": [], "go_terms": [], "name": "Raf1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040859": {"description": "Midline-1, COS domain", "go_ids": [], "go_terms": [], "name": "Midline-1_COS", "pathway_ids": ["PWY-7511", "R-HSA-877300", "R-HSA-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR040860": {"description": "Gp37/Dip protein", "go_ids": [], "go_terms": [], "name": "Dip", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040861": {"description": "Large polyvalent protein-associated domain 13", "go_ids": [], "go_terms": [], "name": "LPD13", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040862": {"description": "Hemagglutinin I", "go_ids": [], "go_terms": [], "name": "HA1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040863": {"description": "Protein of unknown function DUF5554", "go_ids": [], "go_terms": [], "name": "DUF5554", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040864": {"description": "Protein of unknown function DUF5553", "go_ids": [], "go_terms": [], "name": "DUF5553", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040865": {"description": "Primase X", "go_ids": [], "go_terms": [], "name": "PriX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040866": {"description": "Type III secretion system ExsE", "go_ids": [], "go_terms": [], "name": "T3SS_ExsE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040867": {"description": "L-serine kinase SerK, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SerK_C", "pathway_ids": ["PWY-7694", "PWY-8381", "PWY-8008", "PWY-7706"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-8381:t:sulfazecin biosynthesis", "PWY-8008:t:staphyloferrin B biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR040868": {"description": "Histidine kinase DraK, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DraK_HK_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040869": {"description": "Cyclic nucleotide phosphodiesterase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CNP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040870": {"description": "HEN1, double-stranded RNA binding domain 2", "go_ids": [], "go_terms": [], "name": "HEN1_dsRBD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040871": {"description": "HopA1 effector protein", "go_ids": [], "go_terms": [], "name": "HopA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040872": {"description": "Fibrillin 1, unique N-terminal domain", "go_ids": [], "go_terms": [], "name": "Fibrillin_U_N", "pathway_ids": ["R-HSA-1474228", "R-HSA-2129379", "R-BTA-1566948", "R-HSA-216083", "R-MMU-2173789", "R-BTA-1474228", "R-HSA-1566948", "R-BTA-2173789", "R-MMU-8957275", "R-BTA-8957275", "R-MMU-381426", "R-BTA-381426", "R-MMU-216083", "R-HSA-8957275", "R-MMU-1566948", "R-BTA-216083", "R-BTA-2129379", "R-HSA-381426", "R-HSA-2173789", "R-MMU-2129379", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-BTA-1566948:r:Elastic fibre formation", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-1566948:r:Elastic fibre formation", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1566948:r:Elastic fibre formation", "R-BTA-216083:r:Integrin cell surface interactions", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR040873": {"description": "SopB, HTH domain", "go_ids": [], "go_terms": [], "name": "SoPB_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040874": {"description": "Protein of of unknown function DUF5551", "go_ids": [], "go_terms": [], "name": "DUF5551", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040875": {"description": "Trypsin inhibitor", "go_ids": [], "go_terms": [], "name": "Tryp_inh", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040876": {"description": "Lantibiotic immunity protein Spa1, C-terminal", "go_ids": [], "go_terms": [], "name": "Spa1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040877": {"description": "Carbohydrate binding module 65 domain 1", "go_ids": [], "go_terms": [], "name": "CBM65_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040878": {"description": "IL-40-like, Ig domain", "go_ids": [], "go_terms": [], "name": "IL-40-like_Ig", "pathway_ids": ["R-HSA-6798695", "R-SSC-6798695", "R-HSA-216083", "R-SSC-432142", "R-SSC-114608", "R-HSA-432142", "R-MMU-210990", "R-SSC-202733", "R-MMU-432142", "R-HSA-114608", "R-HSA-210990", "R-SSC-216083", "R-MMU-202733", "R-SSC-210990", "R-MMU-216083", "R-MMU-6798695", "R-HSA-9856530", "R-HSA-202733", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-216083:r:Integrin cell surface interactions", "R-SSC-432142:r:Platelet sensitization by LDL", "R-SSC-114608:r:Platelet degranulation", "R-HSA-432142:r:Platelet sensitization by LDL", "R-MMU-210990:r:PECAM1 interactions", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-MMU-432142:r:Platelet sensitization by LDL", "R-HSA-114608:r:Platelet degranulation", "R-HSA-210990:r:PECAM1 interactions", "R-SSC-216083:r:Integrin cell surface interactions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-SSC-210990:r:PECAM1 interactions", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR040879": {"description": "Spermatogenesis-associated protein 46-like", "go_ids": [], "go_terms": [], "name": "Spt46-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040880": {"description": "Domain of unknown function DUF5604", "go_ids": [], "go_terms": [], "name": "DUF5604", "pathway_ids": ["R-HSA-9843940", "R-DRE-9843940", "R-HSA-3214841", "R-MMU-3214841", "R-MMU-9843940", "R-DRE-3214841", "R-HSA-9843970", "R-DRE-9843970"], "pathways": ["R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "type": "Domain"}, "IPR040881": {"description": "Urease subunit beta-alpha, linker domain", "go_ids": [], "go_terms": [], "name": "Urease_linker", "pathway_ids": ["PWY-5704"], "pathways": ["PWY-5704:t:urea degradation II"], "type": "Domain"}, "IPR040882": {"description": "Cas12a, nuclease domain", "go_ids": [], "go_terms": [], "name": "Cas12a_NUC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040883": {"description": "Fatty acid synthase, meander beta sheet domain", "go_ids": ["GO:0019171"], "go_terms": ["GO:0019171:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity:F"], "name": "FAS_meander", "pathway_ids": ["PWY-8174", "PWY-5147", "PWY-5142", "PWY-8427", "PWY-6799", "PWY-8280", "PWY-6519", "PWY-8203", "PWY-7663", "PWY-5367", "PWY-7746", "PWY-8438", "PWY-5989", "PWY-4381", "PWY-5966", "PWY-7723", "PWY-8012", "PWY-5971", "PWY-8173", "PWY-6113", "PWY-5366", "PWY-7664", "PWY-8175", "PWY-7858", "PWY-8049", "PWYG-321", "PWY-7388", "PWY-5994", "PWY-5973", "PWY-8279", "PWY-8047", "PWY-6282"], "pathways": ["PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-5147:t:oleate biosynthesis I (plants)", "PWY-5142:t:acyl-[acyl-carrier protein] thioesterase pathway", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWY-5367:t:petroselinate biosynthesis", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-7723:t:bacterial bioluminescence", "PWY-8012:t:mupirocin biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "PWY-6113:t:superpathway of mycolate biosynthesis", "PWY-5366:t:palmitoleate biosynthesis II (plants and bacteria)", "PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8049:t:pederin biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8279:t:palmitate biosynthesis III", "PWY-8047:t:bryostatin biosynthesis", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"], "type": "Domain"}, "IPR040884": {"description": "SMODS and SLOG-associating 2TM effector domain 1", "go_ids": [], "go_terms": [], "name": "SLATT_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040885": {"description": "Synaptotagmin-like, mitochondrial and lipid-binding domain", "go_ids": [], "go_terms": [], "name": "SMP_C2CD2L", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040886": {"description": "TRIF, N-terminal", "go_ids": [], "go_terms": [], "name": "TRIF_N", "pathway_ids": ["R-MMU-140534", "R-HSA-168164", "R-HSA-5602571", "R-HSA-9013973", "R-HSA-9828211", "R-HSA-5602566", "R-MMU-937072", "R-HSA-9824878", "R-HSA-975163", "R-MMU-166166", "R-HSA-166166", "R-HSA-936964", "R-HSA-1810476", "R-HSA-2562578", "R-HSA-168927", "R-HSA-9014325", "R-HSA-937041", "R-MMU-975163", "R-MMU-2562578", "R-HSA-140534", "R-HSA-937072", "R-MMU-937041", "R-HSA-9013957", "R-MMU-9824878", "R-MMU-936964"], "pathways": ["R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-5602566:r:TICAM1 deficiency - HSE", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-166166:r:MyD88-independent TLR4 cascade", "R-HSA-166166:r:MyD88-independent TLR4 cascade", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "type": "Domain"}, "IPR040887": {"description": "Aldos-2-ulose dehydratase/isomerase (AUDH), Cupin domain", "go_ids": [], "go_terms": [], "name": "AUDH_Cupin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040888": {"description": "PilN biogenesis protein dimerization domain", "go_ids": [], "go_terms": [], "name": "PilN_bio_d", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040890": {"description": "CopZ, zinc binding domain", "go_ids": [], "go_terms": [], "name": "Znf_CopZ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040891": {"description": "SAV_6107-like HEPN", "go_ids": [], "go_terms": [], "name": "HEPN_SAV_6107", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040892": {"description": "RPN1, N-terminal", "go_ids": [], "go_terms": [], "name": "RPN1_N", "pathway_ids": ["R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-HSA-174178", "R-RNO-8948751", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-MMU-8941858", "R-HSA-5689880", "R-BTA-1234176", "R-BTA-9755511", "R-HSA-8951664", "R-HSA-9010553", "R-HSA-75815", "R-MMU-174154", "R-MMU-69017", "R-RNO-382556", "R-RNO-5687128", "R-MMU-9020702", "R-MMU-8948751", "R-MMU-69481", "R-BTA-350562", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-BTA-75815", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-BTA-69601", "R-MMU-5668541", "R-HSA-8854050", "R-RNO-8854050", "R-BTA-5607761", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-RNO-450408", "R-MMU-174084", "R-BTA-68867", "R-HSA-211733", "R-HSA-1234176", "R-RNO-4641258", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-DDI-174084", "R-MMU-68867", "R-MMU-9932298", "R-MMU-1234176", "R-RNO-5689880", "R-MMU-4641258", "R-DDI-4641258", "R-RNO-8951664", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-HSA-1236974", "R-MMU-5687128", "R-RNO-5358346", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-RNO-69481", "R-DDI-187577", "R-RNO-6798695", "R-RNO-9932298", "R-HSA-68949", "R-BTA-1236978", "R-HSA-5610785", "R-RNO-5632684", "R-HSA-2467813", "R-RNO-1234176", "R-DDI-382556", "R-RNO-5676590", "R-BTA-195253", "R-MMU-187577", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-RNO-174178", "R-RNO-69601", "R-MMU-68949", "R-BTA-4608870", "R-BTA-5676590", "R-HSA-9824272", "R-DDI-174178", "R-MMU-174178", "R-MMU-349425", "R-MMU-8939236", "R-BTA-2871837", "R-HSA-9907900", "R-BTA-174154", "R-RNO-4641257", "R-DDI-5689603", "R-DDI-69601", "R-DDI-2467813", "R-BTA-174184", "R-RNO-349425", "R-MMU-9762114", "R-HSA-9762114", "R-DDI-5689880", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-BTA-8939236", "R-HSA-5610780", "R-MMU-382556", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-187577", "R-BTA-9931269", "R-DDI-9907900", "R-RNO-9755511", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-RNO-174113", "R-BTA-9929356", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-8939902", "R-RNO-187577", "R-MMU-174184", "R-RNO-68867", "R-MMU-8939902", "R-RNO-350562", "R-RNO-9762114", "R-BTA-9954709", "R-RNO-69017", "R-RNO-195253", "R-HSA-8939236", "R-HSA-5358346", "R-SPO-350562", "R-BTA-983168", "R-HSA-6798695", "R-DDI-8854050", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-BTA-5610785", "R-MMU-5607764", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-BTA-5668541", "R-BTA-6798695", "R-HSA-9766229", "R-HSA-5676590", "R-DDI-1236978", "R-DDI-8951664", "R-DDI-5632684", "R-MMU-8951664", "R-BTA-9929491", "R-RNO-174154", "R-HSA-4641257", "R-RNO-202424", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9929491", "R-MMU-9929356", "R-SCE-5668541", "R-RNO-5607761", "R-RNO-9929356", "R-HSA-68867", "R-MMU-9907900", "R-HSA-69481", "R-BTA-174084", "R-BTA-450408", "R-DDI-5658442", "R-BTA-5687128", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-HSA-9755511", "R-RNO-9931269", "R-HSA-4641258", "R-SPO-5689603", "R-RNO-8939236", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-RNO-174184", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-HSA-4608870", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-RNO-2467813", "R-RNO-983168", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-SPO-6798695", "R-HSA-187577", "R-MMU-5610780", "R-DDI-9755511", "R-BTA-382556", "R-BTA-8941858", "R-HSA-349425", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-DDI-75815", "R-MMU-350562", "R-MMU-69601", "R-HSA-2871837", "R-RNO-5689603", "R-BTA-2467813", "R-RNO-5610780", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-MMU-5658442", "R-RNO-8852276", "R-MMU-5689603", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-HSA-5607764", "R-RNO-1236978", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-BTA-8948751", "R-RNO-9907900", "R-RNO-4608870", "R-RNO-9929491", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-SCE-9907900", "R-BTA-5689603", "R-HSA-5668541", "R-HSA-9929356", "R-DDI-983168", "R-DDI-349425", "R-HSA-5687128", 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GAPs", "R-RNO-9766229:r:Degradation of CDH1", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Domain"}, "IPR040893": {"description": "RPA-related protein RADX", "go_ids": ["GO:0003697"], "go_terms": ["GO:0003697:single-stranded DNA binding:F"], "name": "RADX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040894": {"description": "Large ribosomal subunit protein bL17m, C-terminal, fungi", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL17m_C", "pathway_ids": [], 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"R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-MMU-1169091", "R-BTA-9929356", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-8939902", "R-MMU-174184", "R-MMU-8939902", "R-BTA-9954709", "R-HSA-8939236", "R-SPO-350562", "R-HSA-5358346", "R-BTA-983168", "R-HSA-6798695", "R-DDI-8854050", "R-MMU-5632684", "R-SPO-9907900", "R-BTA-5610785", "R-MMU-5607764", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-HSA-9766229", "R-BTA-5668541", "R-BTA-6798695", "R-HSA-5676590", "R-DDI-1236978", "R-DDI-5632684", "R-DDI-8951664", "R-MMU-8951664", "R-BTA-9929491", "R-HSA-4641257", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9929356", "R-MMU-9929491", "R-SCE-5668541", "R-HSA-68867", "R-MMU-9907900", "R-HSA-69481", "R-BTA-174084", "R-BTA-450408", "R-DDI-5658442", "R-BTA-5687128", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-HSA-9755511", "R-HSA-4641258", "R-SPO-5689603", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-HSA-1169091", "R-HSA-4608870", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-SPO-6798695", "R-HSA-187577", "R-MMU-5610780", "R-DDI-9755511", "R-BTA-382556", "R-HSA-349425", "R-BTA-8941858", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-DDI-75815", "R-MMU-350562", "R-MMU-69601", "R-HSA-2871837", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-MMU-5658442", "R-MMU-5689603", "R-HSA-174084", "R-MMU-4608870", "R-HSA-5607764", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-BTA-8948751", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-SCE-9907900", "R-HSA-5668541", "R-BTA-5689603", "R-HSA-9929356", "R-DDI-983168", "R-DDI-349425", "R-HSA-5687128", "R-HSA-69017", "R-BTA-9020702", "R-MMU-983168", "R-BTA-5607764", "R-DDI-450408", "R-MMU-1236978", "R-HSA-350562", "R-HSA-202424", "R-DDI-174154", "R-MMU-450408", "R-HSA-9020702", "R-HSA-174178", "R-HSA-9604323", "R-MMU-8941858", "R-BTA-5689880", "R-HSA-5689880", "R-HSA-8951664", "R-HSA-9010553", "R-BTA-9755511", "R-BTA-1234176", "R-HSA-75815", "R-MMU-174154", "R-MMU-69017", "R-MMU-9020702", "R-MMU-8948751", "R-MMU-69481", "R-BTA-350562", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-BTA-75815", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-BTA-69601", "R-MMU-5668541", "R-HSA-8854050", "R-BTA-5607761", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-BTA-68867", "R-HSA-1234176", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-DDI-174084", "R-MMU-68867", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-BTA-69017", "R-HSA-180534", "R-HSA-1236974", "R-BTA-4641257", "R-MMU-5687128", "R-MMU-9766229", "R-BTA-349425"], "pathways": ["R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-HSA-9824272:r:Somitogenesis", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9907900:r:Proteasome assembly", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-5689603:r:UCH proteinases", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4641257:r:Degradation of AXIN", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-4641258:r:Degradation of DVL", "R-SPO-5689603:r:UCH proteinases", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5689603:r:UCH proteinases", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-5689603:r:UCH proteinases", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689603:r:UCH proteinases", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-1236974:r:ER-Phagosome pathway", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1"], "type": "Domain"}, "IPR040897": {"description": "Plasmodium host cell traversal SPECT1", "go_ids": [], "go_terms": [], "name": "SPECT1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040898": {"description": "CxC6 like cysteine cluster associated with KDZ", "go_ids": [], "go_terms": [], "name": "CxC6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040899": {"description": "Fatty acid synthase subunit alpha, acyl carrier domain", "go_ids": ["GO:0008897"], "go_terms": ["GO:0008897:holo-[acyl-carrier-protein] synthase activity:F"], "name": "Fas_alpha_ACP", "pathway_ids": ["PWY-8174", "PWY-8427", "PWY-8280", "PWY-6519", "PWY-8203", "PWY-7663", "PWY-5367", "PWY-5989", "PWY-5966", "PWY-5971", "PWY-8173", "PWY-6113", "PWY-7664", "PWY-8175", "PWY-7858", "PWYG-321", "PWY-7388", "PWY-5994", "PWY-5973", "PWY-8279", "PWY-6282"], "pathways": ["PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWY-5367:t:petroselinate biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "PWY-6113:t:superpathway of mycolate biosynthesis", "PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWYG-321:t:mycolate biosynthesis", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8279:t:palmitate biosynthesis III", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"], "type": "Domain"}, "IPR040900": {"description": "Spermine synthase, N-terminal", "go_ids": [], "go_terms": [], "name": "SpmSyn_N", "pathway_ids": ["R-MMU-351202", "R-BTA-351202", "R-HSA-351202"], "pathways": ["R-MMU-351202:r:Metabolism of polyamines", "R-BTA-351202:r:Metabolism of polyamines", "R-HSA-351202:r:Metabolism of polyamines"], "type": "Domain"}, "IPR040901": {"description": "Leukemia inhibitory factor receptor, N-terminal", "go_ids": [], "go_terms": [], "name": "LIFR_N", "pathway_ids": ["R-MMU-6788467", "R-HSA-8939247", "R-HSA-6788467", "R-RNO-6788467"], "pathways": ["R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Domain"}, "IPR040902": {"description": "REase, AHJR-like", "go_ids": [], "go_terms": [], "name": "AHJR-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040903": {"description": "Retroviral integrase, C-terminal SH3 domain", "go_ids": [], "go_terms": [], "name": "SH3_11", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR040904": {"description": "Protein of unknown function DUF5557", "go_ids": [], "go_terms": [], "name": "DUF5557", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040905": {"description": "DNA-Binding protein G5P, Pseudomonas", "go_ids": [], "go_terms": [], "name": "SS_DBP_Pseudomonas", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040906": {"description": "Protein of unknown function DUF5535", "go_ids": [], "go_terms": [], "name": "DUF5535", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040907": {"description": "IL-3 receptor alpha chain, N-terminal", "go_ids": [], "go_terms": [], "name": "IL3Ra_N", "pathway_ids": ["R-HSA-5688890", "R-HSA-5683826", "R-HSA-912526", "R-HSA-512988", "R-HSA-5688849", "R-HSA-5673001"], "pathways": ["R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Domain"}, "IPR040908": {"description": "Hydroquinone 1,2-dioxygenase large subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "PnpCD_PnpD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040909": {"description": "E3 ubiquitin-protein ligase CHFR, cysteine rich domain with multizinc binding", "go_ids": [], "go_terms": [], "name": "CHFR_Znf-CRD", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR040910": {"description": "Closterovirus 1a polyprotein, central region", "go_ids": [], "go_terms": [], "name": "Zemlya", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040911": {"description": "Exostosin, GT47 domain", "go_ids": [], "go_terms": [], "name": "Exostosin_GT47", "pathway_ids": ["R-BTA-2022928", "R-HSA-381038", "R-CEL-2022928", "R-HSA-3656253", "R-DME-2022928", "R-DRE-2022928", "R-MMU-2022928", "R-HSA-2022928", "R-HSA-3656237"], "pathways": ["R-BTA-2022928:r:HS-GAG biosynthesis", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-DME-2022928:r:HS-GAG biosynthesis", "R-DRE-2022928:r:HS-GAG biosynthesis", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2"], "type": "Domain"}, "IPR040912": {"description": "Repeat of unknown function DUF5633", "go_ids": [], "go_terms": [], "name": "DUF5633", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040913": {"description": "Htr2, transmembrane domain", "go_ids": [], "go_terms": [], "name": "Htr2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040914": {"description": "PH0542 repeat", "go_ids": [], "go_terms": [], "name": "PH0542", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040915": {"description": "GK1464-like domain", "go_ids": [], "go_terms": [], "name": "GK1464-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040916": {"description": "DD-reactivating factor swiveling domain", "go_ids": [], "go_terms": [], "name": "DDR_swiveling", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040917": {"description": "RalF, C-terminal Sec-7 capping domain", "go_ids": [], "go_terms": [], "name": "RalF_SCD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040918": {"description": "GatD, N-terminal", "go_ids": [], "go_terms": [], "name": "GatD_N", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Domain"}, "IPR040919": {"description": "Asparaginase/glutaminase, C-terminal", "go_ids": [], "go_terms": [], "name": "Asparaginase_C", "pathway_ids": ["R-HSA-8963693", "R-RNO-8963693", "R-MMU-8963693"], "pathways": ["R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-MMU-8963693:r:Aspartate and asparagine metabolism"], "type": "Domain"}, "IPR040920": {"description": "Arabinosyltransferas, concanavalin like domain", "go_ids": [], "go_terms": [], "name": "Arabino_trans_N", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis"], "type": "Domain"}, "IPR040921": {"description": "LD-carboxypeptidase, C-terminal", "go_ids": [], "go_terms": [], "name": "Peptidase_S66C", "pathway_ids": ["PWY-6470", "PWY-5707", "PWY-5706", "PWY-7614"], "pathways": ["PWY-6470:t:peptidoglycan biosynthesis V (beta-lactam resistance)", "PWY-5707:t:propanethial S-oxide biosynthesis", "PWY-5706:t:alliin metabolism", "PWY-7614:t:methiin metabolism"], "type": "Domain"}, "IPR040922": {"description": "Large ribosomal subunit protein mL59 domain", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL59_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040923": {"description": "4-hydroxyphenylacetate decarboxylase small gamma subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "HpdC_C", "pathway_ids": ["PWY-7514"], "pathways": ["PWY-7514:t:L-tyrosine degradation IV (to 4-methylphenol)"], "type": "Domain"}, "IPR040924": {"description": "5-hmdU DNA kinase", "go_ids": [], "go_terms": [], "name": "HMUDK/HMUD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040925": {"description": "Heparinase II, C-terminal", "go_ids": [], "go_terms": [], "name": "HepII_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040926": {"description": "Cellular tumor antigen p53, transactivation domain 2", "go_ids": [], "go_terms": [], "name": "p53_TAD2", "pathway_ids": ["R-HSA-8853884", "R-HSA-9819196", "R-HSA-6804115", "R-HSA-2559580", "R-HSA-9833482", "R-HSA-5689896", "R-HSA-5689880", "R-HSA-349425", "R-HSA-2559585", "R-HSA-5620971", "R-HSA-6803205", "R-HSA-5693565", "R-HSA-6796648", "R-HSA-2559586", "R-HSA-5628897", "R-HSA-139915", "R-HSA-1912408", "R-HSA-6804758", "R-HSA-6804759", "R-HSA-6804754", "R-HSA-6804757", "R-HSA-8941855", "R-HSA-8943724", "R-HSA-2559584", "R-HSA-6803211", "R-HSA-69481", "R-HSA-390471", "R-HSA-6803207", "R-HSA-9723905", "R-HSA-69473", "R-HSA-983231", "R-HSA-8852276", "R-HSA-9758274", "R-HSA-70635", "R-HSA-69895", "R-HSA-6785807", "R-HSA-6804760", "R-HSA-6811555", "R-HSA-6804756", "R-HSA-6803204", "R-HSA-6804114", "R-HSA-111448", "R-HSA-3232118", "R-HSA-69541", "R-HSA-9725370", "R-HSA-6804116"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-5620971:r:Pyroptosis", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-6804754:r:Regulation of TP53 Expression", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-69481:r:G2/M Checkpoints", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-9723905:r:Loss of function of TP53 in cancer due to loss of tetramerization ability", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-70635:r:Urea cycle", "R-HSA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-111448:r:Activation of NOXA and translocation to mitochondria", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-HSA-69541:r:Stabilization of p53", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "type": "Domain"}, "IPR040927": {"description": "Monalysin, Pore-forming domain", "go_ids": [], "go_terms": [], "name": "PF_Monalysin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040928": {"description": "Importin repeat", "go_ids": [], "go_terms": [], "name": "Importin_rep_5", "pathway_ids": ["R-HSA-192905"], "pathways": ["R-HSA-192905:r:vRNP Assembly"], "type": "Repeat"}, "IPR040929": {"description": "Archaellum regulatory network B, C-terminal", "go_ids": [], "go_terms": [], "name": "ArnB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040930": {"description": "AF-9, ANC1 homology domain", "go_ids": [], "go_terms": [], "name": "AF-9_AHD", "pathway_ids": ["R-HSA-674695", "R-HSA-112382", "R-HSA-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Domain"}, "IPR040931": {"description": "Cadmium carbonic anhydrase repeat", "go_ids": [], "go_terms": [], "name": "CDCA", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040932": {"description": "Csm4, C-terminal", "go_ids": [], "go_terms": [], "name": "Csm4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040933": {"description": "Photosystem II Psb31 protein", "go_ids": [], "go_terms": [], "name": "PSII_Pbs31", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040934": {"description": "Mit1, C-terminal Zn finger 2", "go_ids": [], "go_terms": [], "name": "Znf-CCCH_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040935": {"description": "Subtilisin-like protease 2, prodomain", "go_ids": [], "go_terms": [], "name": "Pro_sub2", "pathway_ids": ["R-PFA-2173796"], "pathways": ["R-PFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "type": "Domain"}, "IPR040936": {"description": "Large polyvalent protein associated domain 26", "go_ids": [], "go_terms": [], "name": "LPD26", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040937": {"description": "Argonaute, N-terminal", "go_ids": [], "go_terms": [], "name": "Ago_N_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040938": {"description": "Legionella ubiquitin-specific protease A domain", "go_ids": [], "go_terms": [], "name": "LupA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040939": {"description": "Vacuolar protein sorting 38", "go_ids": ["GO:0034272"], "go_terms": ["GO:0034272:phosphatidylinositol 3-kinase complex, class III, type II:C"], "name": "Vps38", "pathway_ids": ["R-SCE-1632852"], "pathways": ["R-SCE-1632852:r:Macroautophagy"], "type": "Family"}, "IPR040940": {"description": "DNA polymerase nu, pseudo-exo domain", "go_ids": [], "go_terms": [], "name": "DNA_pol_P_Exo", "pathway_ids": ["R-HSA-6783310", "R-MMU-6783310"], "pathways": ["R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR040941": {"description": "Exuperantia, SAM-like domain", "go_ids": [], "go_terms": [], "name": "SAM_Exu", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040942": {"description": "Minimal CRISPR polymerase domain", "go_ids": [], "go_terms": [], "name": "Minimal_Cpol", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040943": {"description": "Protein of unknown function DUF5571", "go_ids": [], "go_terms": [], "name": "DUF5571", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040944": {"description": "Importin 13 repeat 2", "go_ids": [], "go_terms": [], "name": "Importin_rep_2", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR040945": {"description": "Domain of unknown function DUF5621", "go_ids": [], "go_terms": [], "name": "DUF5621", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040946": {"description": "Endoglucanase B, carbohydrate binding domain", "go_ids": [], "go_terms": [], "name": "CBM46", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040947": {"description": "Short myomegalin-like EB1 binding protein, N-terminal", "go_ids": [], "go_terms": [], "name": "SMYLE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040948": {"description": "Domain of unknown function DUF5639", "go_ids": [], "go_terms": [], "name": "DUF5639", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040949": {"description": "HetR, C-terminal Hood domain", "go_ids": [], "go_terms": [], "name": "HetR_C", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR040950": {"description": "ADGRG1, GAIN subdomain A", "go_ids": [], "go_terms": [], "name": "ADGRG1_GAIN_A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040951": {"description": "Interleukin-2 receptor subunit beta, N-terminal", "go_ids": [], "go_terms": [], "name": "IL2RB_N1", "pathway_ids": ["R-RNO-5673001", "R-MMU-912526", "R-HSA-912526", "R-RNO-9020558", "R-MMU-9020558", "R-MMU-8983432", "R-RNO-8983432", "R-HSA-8983432", "R-MMU-5673001", "R-RNO-912526", "R-HSA-9020558", "R-HSA-5673001"], "pathways": ["R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-RNO-9020558:r:Interleukin-2 signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-RNO-8983432:r:Interleukin-15 signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Domain"}, "IPR040953": {"description": "Domain of unknown function DUF5594", "go_ids": [], "go_terms": [], "name": "DUF5594", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040954": {"description": "ZAP, zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-CCCH_8", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR040955": {"description": "Immune mapped protein 2, N-terminal", "go_ids": [], "go_terms": [], "name": "IMP2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040956": {"description": "Lower baseplate protein, N-terminal", "go_ids": [], "go_terms": [], "name": "BppL_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040957": {"description": "Anosmin-1, cysteine rich domain", "go_ids": [], "go_terms": [], "name": "Anosmin-1_Cys_box", "pathway_ids": ["R-GGA-190373", "R-HSA-190373", "R-HSA-5654726", "R-GGA-5654726"], "pathways": ["R-GGA-190373:r:FGFR1c ligand binding and activation", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling"], "type": "Domain"}, "IPR040958": {"description": "Secreted Novel AID/APOBEC-like Deaminase 1", "go_ids": [], "go_terms": [], "name": "SNAD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040959": {"description": "Cellulose-binding protein CttA, N-terminal", "go_ids": [], "go_terms": [], "name": "CttA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040960": {"description": "Homeobox-cysteine loop-homeobox", "go_ids": [], "go_terms": [], "name": "HOCHOB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040961": {"description": "Cop9 signalosome subunit 5 C-terminal domain", "go_ids": [], "go_terms": [], "name": "CSN5_C", "pathway_ids": ["R-DRE-8856825", "R-DME-8856825", "R-MMU-8856825", "R-DME-6781823", "R-CEL-8856825", "R-HSA-8951664", "R-DME-8951664", "R-DRE-8951664", "R-DDI-6781823", "R-DRE-5696394", "R-DME-5696394", "R-DDI-8951664", "R-HSA-6781823", "R-CEL-6781823", "R-MMU-8951664", "R-DDI-8856825", "R-MMU-6781823", "R-HSA-9929356", "R-DDI-5696394", "R-HSA-8856825", "R-HSA-5696394", "R-MMU-9929356", "R-MMU-5696394", "R-CEL-5696394", "R-DRE-6781823", "R-CEL-8951664"], "pathways": ["R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR040962": {"description": "Tetratricopeptide-like repeat", "go_ids": [], "go_terms": [], "name": "TPR_22", "pathway_ids": ["R-SCE-429958", "R-SPO-429958"], "pathways": ["R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Repeat"}, "IPR040963": {"description": "Magnetochrome domain", "go_ids": [], "go_terms": [], "name": "MCR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040964": {"description": "OAA-family lectin sugar binding domain", "go_ids": [], "go_terms": [], "name": "SBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040965": {"description": "Protein of unknown function DUF5559", "go_ids": [], "go_terms": [], "name": "DUF5559", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040966": {"description": "Metalloprotease StcE, C-terminal", "go_ids": [], "go_terms": [], "name": "StcE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040967": {"description": "Domain of unknown function DUF5595", "go_ids": [], "go_terms": [], "name": "DUF5595", "pathway_ids": ["R-MMU-2500257", "R-XTR-9648025", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-DRE-2500257", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-HSA-9648025", "R-XTR-68877", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-GGA-2500257", "R-GGA-141444", "R-XTR-141444", "R-HSA-68877", "R-GGA-9648025", "R-GGA-5663220", "R-HSA-5663220", "R-DRE-5663220", "R-GGA-2467813", "R-MMU-9648025", "R-XTR-2500257", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR040968": {"description": "EZH2, MCSS domain, fungal", "go_ids": [], "go_terms": [], "name": "EZH2_MCSS_fung", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040969": {"description": "Insulin receptor, trans-membrane domain", "go_ids": [], "go_terms": [], "name": "Insulin_TMD", "pathway_ids": ["R-MMU-77387", "R-MMU-74713", "R-HSA-74713", "R-HSA-74751", "R-MMU-6811558", "R-HSA-77387", "R-RNO-74752", "R-MMU-74752", "R-RNO-74749", "R-HSA-74749", "R-RNO-77387", "R-RNO-74713", "R-HSA-6811558", "R-RNO-74751", "R-RNO-6811558", "R-HSA-74752", "R-MMU-74751", "R-MMU-74749"], "pathways": ["R-MMU-77387:r:Insulin receptor recycling", "R-MMU-74713:r:IRS activation", "R-HSA-74713:r:IRS activation", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-77387:r:Insulin receptor recycling", "R-RNO-74752:r:Signaling by Insulin receptor", "R-MMU-74752:r:Signaling by Insulin receptor", "R-RNO-74749:r:Signal attenuation", "R-HSA-74749:r:Signal attenuation", "R-RNO-77387:r:Insulin receptor recycling", "R-RNO-74713:r:IRS activation", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-74752:r:Signaling by Insulin receptor", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-MMU-74749:r:Signal attenuation"], "type": "Domain"}, "IPR040970": {"description": "CadC, C-terminal domain 1", "go_ids": [], "go_terms": [], "name": "CadC_C1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040971": {"description": "Pleurotolysin B, C-terminal", "go_ids": [], "go_terms": [], "name": "PlyB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040972": {"description": "ALMS repeat", "go_ids": [], "go_terms": [], "name": "ALMS_repeat", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-MMU-380270", "R-HSA-380284", "R-MMU-380284", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-2565942", "R-HSA-380270", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Repeat"}, "IPR040973": {"description": "Inactive serine protease scarface, clip-domain", "go_ids": [], "go_terms": [], "name": "CLIP_SPH_Scar", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040974": {"description": "Purple acid phosphatase, Fn3-like domain", "go_ids": [], "go_terms": [], "name": "Fn3_PAP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040975": {"description": "RnaseLS-like HEPN domain", "go_ids": [], "go_terms": [], "name": "HEPN_RnaseLS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040976": {"description": "Fungal-type protein kinase", "go_ids": [], "go_terms": [], "name": "Pkinase_fungal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040977": {"description": "HP1451, C-terminal", "go_ids": [], "go_terms": [], "name": "HP1451_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040978": {"description": "Isocitrate dehydrogenase/Hypothetical protein TT1725, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Isocitrate_DH_TT1725_C", "pathway_ids": ["PWY-6549", "PWY-7254", "PWY-7124", "PWY-5913", "PWY-7268", "PWY-6728", "PWY-6969"], "pathways": ["PWY-6549:t:nitrogen remobilization from senescing leaves", "PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7268:t:cytosolic NADPH production (yeast)", "PWY-6728:t:methylaspartate cycle", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)"], "type": "Domain"}, "IPR040979": {"description": "Vid27, N-terminal", "go_ids": [], "go_terms": [], "name": "Vid27_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040980": {"description": "SWI2/SNF2 ATPase", "go_ids": [], "go_terms": [], "name": "SWI2_SNF2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040981": {"description": "Fatty acid synthase subunit PfaD, N-terminal", "go_ids": [], "go_terms": [], "name": "PfaD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040982": {"description": "DNA polymerase III alpha subunit finger domain", "go_ids": [], "go_terms": [], "name": "DNA_pol3_finger", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040983": {"description": "Bacterial archaeo-eukaryotic release factor family 5", "go_ids": [], "go_terms": [], "name": "Bact_RF_family5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR040984": {"description": "Domain of unknown function DUF5640", "go_ids": [], "go_terms": [], "name": "DUF5640", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040985": {"description": "Nup54, C-terminal interacting domain", "go_ids": [], "go_terms": [], "name": "Nup54_C", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-3108214", "R-HSA-191859", "R-HSA-9705671", "R-RNO-3301854", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-MMU-159230", "R-HSA-159227", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230", "R-MMU-4551638", "R-MMU-4085377", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-HSA-4570464", "R-DME-4615885", "R-RNO-159236", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-MMU-3301854", "R-DME-4551638", "R-HSA-4085377", "R-HSA-168325", "R-DME-159227", "R-MMU-170822", "R-RNO-159227", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-RNO-4551638", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-RNO-4085377", "R-HSA-9615933", "R-DME-159230", "R-RNO-170822", "R-DME-3301854", "R-RNO-159231", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-191859:r:snRNP Assembly", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Domain"}, "IPR040986": {"description": "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain", "go_ids": [], "go_terms": [], "name": "QSOX_FAD-bd_dom", "pathway_ids": ["PWY-7533", "R-RNO-381426", "R-HSA-6798695", "R-HSA-114608", "R-RNO-8957275", "R-MMU-381426", "R-MMU-6798695", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR040987": {"description": "TraI, N-terminal subdomain", "go_ids": [], "go_terms": [], "name": "TraI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040988": {"description": "Domain of unknown function DUF5618", "go_ids": [], "go_terms": [], "name": "DUF5618", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040989": {"description": "Major vault protein repeat domain 3", "go_ids": [], "go_terms": [], "name": "Vault_3", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR040990": {"description": "Domain of unknown function DUF5600", "go_ids": [], "go_terms": [], "name": "DUF5600", "pathway_ids": ["R-HSA-983231", "R-MMU-983231", "R-RNO-983231", "R-BTA-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR040992": {"description": "5'-3' exoribonuclease 1, D1 domain", "go_ids": [], "go_terms": [], "name": "XRN1_D1", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-MMU-450513", "R-HSA-450513", "R-SCE-450513", "R-HSA-9918487", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR040993": {"description": "Histone chaperone Rtt106, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Rtt106_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040994": {"description": "SUN coiled coil domain 2", "go_ids": [], "go_terms": [], "name": "Sun_CC2", "pathway_ids": ["R-HSA-9918487", "R-HSA-1221632"], "pathways": ["R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-1221632:r:Meiotic synapsis"], "type": "Domain"}, "IPR040997": {"description": "IL-7Ralpha, fibronectin type III domain", "go_ids": [], "go_terms": [], "name": "FN3_7", "pathway_ids": ["R-HSA-1266695", "R-MMU-8856828", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-1266695"], "pathways": ["R-HSA-1266695:r:Interleukin-7 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1266695:r:Interleukin-7 signaling"], "type": "Domain"}, "IPR040998": {"description": "Barnase-EndoU-ColicinE5/D-RelE like", "go_ids": [], "go_terms": [], "name": "PBECR5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR040999": {"description": "Maltokinase N-terminal cap domain", "go_ids": [], "go_terms": [], "name": "Mak_N_cap", "pathway_ids": ["PWY-7900"], "pathways": ["PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)"], "type": "Domain"}, "IPR041000": {"description": "Gammaproteobacterial serine protease", "go_ids": [], "go_terms": [], "name": "Serine_protease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041001": {"description": "Phosphoglucose isomerase, N-terminal", "go_ids": [], "go_terms": [], "name": "PG_isomerase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041002": {"description": "RK-1-like defensin", "go_ids": [], "go_terms": [], "name": "Defensin_RK-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041003": {"description": "EXOG, C-terminal", "go_ids": [], "go_terms": [], "name": "Exog_C", "pathway_ids": ["R-HSA-9913635"], "pathways": ["R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR041004": {"description": "Cell-traversal protein for ookinetes and sporozoites", "go_ids": [], "go_terms": [], "name": "CelTOS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041005": {"description": "DNA polymerase II intein domain IV", "go_ids": [], "go_terms": [], "name": "PI-TkoII_IV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041006": {"description": "Morc, S5 domain 2-like", "go_ids": [], "go_terms": [], "name": "Morc_S5", "pathway_ids": ["R-MMU-75105", "R-HSA-9843970", "R-HSA-75105"], "pathways": ["R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR041007": {"description": "Copper(I)-binding protein CorA", "go_ids": [], "go_terms": [], "name": "Cu_bind_CorA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041008": {"description": "Domain of unknown function DUF5625", "go_ids": [], "go_terms": [], "name": "DUF5625", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041009": {"description": "Protein of unknown function DUF5550", "go_ids": [], "go_terms": [], "name": "DUF5550", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041010": {"description": "Acetyl-coA carboxylase zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf-ACC", "pathway_ids": ["PWY-5743", "PWY-5789", "PWY-6722", "PWY-4381", "PWY-5744"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-6722:t:candicidin biosynthesis", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "PWY-5744:t:glyoxylate assimilation"], "type": "Domain"}, "IPR041011": {"description": "ZBTB21, zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041012": {"description": "Flap endonuclease GEN, chromatin organization modifier domain", "go_ids": [], "go_terms": [], "name": "GEN_chromo", "pathway_ids": ["R-HSA-5693568", "R-MMU-5693568"], "pathways": ["R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates"], "type": "Domain"}, "IPR041013": {"description": "Allene oxide cyclase barrel-like domain", "go_ids": ["GO:0017000", "GO:0016853"], "go_terms": ["GO:0017000:antibiotic biosynthetic process:P", "GO:0016853:isomerase activity:F"], "name": "AOC-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041014": {"description": "CEL-III, C-terminal", "go_ids": [], "go_terms": [], "name": "CEL_III_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041015": {"description": "Toll-like receptor 3 trans-membrane domain", "go_ids": [], "go_terms": [], "name": "TLR3_TMD", "pathway_ids": ["R-HSA-1810476", "R-HSA-1679131", "R-HSA-5602410", "R-HSA-168164", "R-HSA-168927", "R-HSA-9013973", "R-HSA-5602571", "R-HSA-9828211", "R-HSA-9014325", "R-HSA-5602566", "R-HSA-9833110", "R-HSA-5602415", "R-HSA-9013957"], "pathways": ["R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-5602410:r:TLR3 deficiency - HSE", "R-HSA-168164:r:Toll Like Receptor 3 (TLR3) Cascade", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-5602566:r:TICAM1 deficiency - HSE", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-5602415:r:UNC93B1 deficiency - HSE", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death"], "type": "Domain"}, "IPR041016": {"description": "Bdellovibrio, beta-sandwich", "go_ids": [], "go_terms": [], "name": "BD_b_sandwich", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041017": {"description": "DipZ, thioredoxin-like C-terminal domain", "go_ids": [], "go_terms": [], "name": "Thioredoxin_10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041018": {"description": "Tse2 ADP-ribosyltransferase toxin", "go_ids": [], "go_terms": [], "name": "ADPRTs_Tse2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041019": {"description": "Plexin, TIG domain 1", "go_ids": [], "go_terms": [], "name": "TIG1_plexin", "pathway_ids": ["R-HSA-9013405", "R-HSA-416550", "R-RNO-399956", "R-HSA-399956", "R-HSA-9013508", "R-HSA-416572", "R-DRE-399954", "R-HSA-9696270", "R-RNO-416700", "R-MMU-399955", "R-HSA-416482", "R-MMU-399956", "R-MMU-416572", "R-RNO-399954", "R-HSA-9615017", "R-DME-416572", "R-HSA-416700", "R-RNO-399955", "R-HSA-399954", "R-DRE-399956", "R-MMU-416482", "R-MMU-399954", "R-DME-416482", "R-HSA-399955", "R-DME-416700", "R-HSA-9696273", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-416700", "R-MMU-416550"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-416700:r:Other semaphorin interactions", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-416482:r:G alpha (12/13) signalling events", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-416700:r:Other semaphorin interactions", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration"], "type": "Domain"}, "IPR041020": {"description": "ARHGEF1-like, PH domain", "go_ids": [], "go_terms": [], "name": "PH_16", "pathway_ids": ["R-RNO-9013026", "R-HSA-416572", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-2173791", "R-RNO-416572", "R-RNO-9013149", "R-HSA-9013106", "R-MMU-9013148", "R-MMU-416572", "R-HSA-3928662", "R-RNO-416482", "R-HSA-9013148", "R-RNO-3928662", "R-CFA-416572", "R-RNO-9013106", "R-RNO-193648", "R-HSA-193648", "R-CFA-9013148", "R-CFA-8980692", "R-HSA-2173791", "R-HSA-416482", "R-RNO-9013148", "R-CFA-416482", "R-HSA-9013149", "R-HSA-8980692", "R-CFA-9013106", "R-MMU-9013026", "R-MMU-416482", "R-MMU-3928662", "R-MMU-193648", "R-HSA-9013026", "R-MMU-9013149", "R-CFA-193648"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-193648:r:NRAGE signals death through JNK", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-CFA-8980692:r:RHOA GTPase cycle", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-CFA-193648:r:NRAGE signals death through JNK"], "type": "Domain"}, "IPR041021": {"description": "5-hmdU DNA kinase 2", "go_ids": [], "go_terms": [], "name": "HMUD2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041024": {"description": "Mcm6, C-terminal winged-helix domain", "go_ids": [], "go_terms": [], "name": "Mcm6_C", "pathway_ids": ["R-XTR-69052", "R-MMU-68867", "R-SPO-176187", "R-SPO-68867", "R-HSA-68949", "R-HSA-176974", "R-CEL-68962", "R-XTR-68962", "R-MMU-68962", "R-MMU-68949", "R-DME-69052", "R-CEL-68867", "R-SPO-69052", "R-HSA-176187", "R-SCE-68962", "R-SCE-69052", "R-DME-68962", "R-CEL-68949", "R-DDI-68962", "R-HSA-69052", "R-XTR-68949", "R-XTR-68867", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-DDI-69052", "R-SPO-68962", "R-DME-176187", "R-SPO-68949", "R-CEL-69052", "R-SCE-176187", "R-SCE-68867", "R-MMU-69052", "R-DDI-68867", "R-DME-68949", "R-DME-68867", "R-HSA-68867"], "pathways": ["R-XTR-69052:r:Switching of origins to a post-replicative state", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-SPO-68867:r:Assembly of the pre-replicative complex", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-176974:r:Unwinding of DNA", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-DME-69052:r:Switching of origins to a post-replicative state", "R-CEL-68867:r:Assembly of the pre-replicative complex", "R-SPO-69052:r:Switching of origins to a post-replicative state", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SCE-69052:r:Switching of origins to a post-replicative state", "R-DME-68962:r:Activation of the pre-replicative complex", "R-CEL-68949:r:Orc1 removal from chromatin", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-XTR-68949:r:Orc1 removal from chromatin", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DDI-69052:r:Switching of origins to a post-replicative state", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-SPO-68949:r:Orc1 removal from chromatin", "R-CEL-69052:r:Switching of origins to a post-replicative state", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68867:r:Assembly of the pre-replicative complex", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-DDI-68867:r:Assembly of the pre-replicative complex", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR041025": {"description": "Homing endonuclease associated repeat", "go_ids": [], "go_terms": [], "name": "HNH_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR041026": {"description": "HEPN like, Abia C-terminal domain", "go_ids": [], "go_terms": [], "name": "HEPN_AbiA_CTD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041027": {"description": "FtsK alpha domain", "go_ids": [], "go_terms": [], "name": "FtsK_alpha", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041028": {"description": "Cdc13, OB4 dimerization domain", "go_ids": [], "go_terms": [], "name": "Cdc13_OB4_dimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041029": {"description": "N-acetylglucosamine binding protein A domain 2", "go_ids": [], "go_terms": [], "name": "GbpA_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041030": {"description": "SHIRT domain", "go_ids": [], "go_terms": [], "name": "SHIRT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041031": {"description": "RNF31, C-terminal", "go_ids": [], "go_terms": [], "name": "RNF31_C", "pathway_ids": ["R-MMU-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357956", "R-HSA-5357786", "R-MMU-5357905"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling"], "type": "Domain"}, "IPR041032": {"description": "Protein of unknown function DUF5546", "go_ids": [], "go_terms": [], "name": "DUF5546", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041033": {"description": "SpaA-like, prealbumin fold domain subgroup 1", "go_ids": [], "go_terms": [], "name": "SpaA_PFL_dom_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041034": {"description": "Phosphoinositide phosphatase, C-terminal", "go_ids": [], "go_terms": [], "name": "PI_PP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041035": {"description": "TbRIF5 SNase domain 1", "go_ids": [], "go_terms": [], "name": "RIF5_SNase_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041036": {"description": "Glycoside hydrolase family 5, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GH5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041037": {"description": "Pallilysin, beta barrel domain", "go_ids": [], "go_terms": [], "name": "Pallilysin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041038": {"description": "TarS, C-terminal domain 1", "go_ids": [], "go_terms": [], "name": "TarS_C1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041039": {"description": "Yos9, dimerzation domain", "go_ids": [], "go_terms": [], "name": "Yos9_DD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041040": {"description": "3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain", "go_ids": [], "go_terms": [], "name": "3HCDH_RFF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041041": {"description": "Protein of unknown function DUF5539", "go_ids": [], "go_terms": [], "name": "DUF5539", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041042": {"description": "Hakai, C2H2 zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_Hakai", "pathway_ids": ["PWY-7511", "R-DME-983168", "R-HSA-9766229", "R-HSA-983168", "R-MMU-9766229", "R-MMU-983168", "R-HSA-8876493"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9766229:r:Degradation of CDH1", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9766229:r:Degradation of CDH1", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells"], "type": "Domain"}, "IPR041043": {"description": "Large ribosomal subunit protein aL46", "go_ids": [], "go_terms": [], "name": "RL46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041044": {"description": "Nuclear polyadenylated RNA-binding 2 protein, CCCH zinc finger 1", "go_ids": [], "go_terms": [], "name": "Nab2p_Zf1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041045": {"description": "Large polyvalent protein associated domain 25", "go_ids": [], "go_terms": [], "name": "LPD25", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041046": {"description": "JAK, FERM F2 lobe domain", "go_ids": [], "go_terms": [], "name": "FERM_F2", "pathway_ids": ["R-SSC-5673000", "R-RNO-6785807", "R-HSA-9020958", "R-HSA-6802952", "R-MMU-1266695", "R-HSA-9006335", "R-MMU-9674555", "R-RNO-9020558", "R-RNO-9020591", "R-SSC-912526", "R-SSC-69231", "R-HSA-9732724", "R-HSA-69231", "R-HSA-9027284", "R-RNO-512988", "R-RNO-8854691", "R-RNO-877312", "R-SSC-9020933", "R-MMU-9020958", "R-MMU-201556", "R-HSA-5673000", "R-MMU-9732724", "R-RNO-983231", "R-SSC-112411", "R-SSC-982772", "R-HSA-512988", "R-SSC-9705462", "R-SSC-1170546", "R-MMU-909733", "R-HSA-6802955", "R-HSA-2586552", "R-SSC-9674555", "R-HSA-9027283", "R-HSA-8984722", "R-MMU-5673001", "R-HSA-9931295", "R-RNO-5673000", "R-DRE-112411", "R-HSA-1170546", "R-RNO-9732724", "R-HSA-983231", "R-MMU-5673000", "R-RNO-9705462", "R-DRE-909733", "R-DRE-912694", "R-HSA-8983432", "R-SSC-9027284", "R-RNO-9020958", "R-MMU-912526", "R-DRE-6785807", "R-RNO-9006335", "R-HSA-909733", "R-DRE-8983432", "R-SSC-1433557", "R-HSA-8985947", "R-MMU-6785807", "R-HSA-9656223", "R-HSA-9833109", "R-HSA-9705671", "R-HSA-1059683", "R-DRE-877312", "R-MMU-9020956", "R-HSA-6788467", "R-SSC-8854691", "R-RNO-9027284", "R-MMU-9020591", "R-HSA-877312", "R-MMU-512988", "R-RNO-6788467", "R-HSA-9027276", "R-MMU-877312", "R-HSA-9020558", "R-MMU-9027284", "R-RNO-1170546", "R-SSC-1059683", "R-SSC-9006335", "R-MMU-8983432", "R-HSA-110056", "R-RNO-69231", "R-HSA-912526", "R-HSA-877300", "R-SSC-983231", "R-HSA-201556", "R-HSA-9027277", "R-HSA-9725370", "R-HSA-9020956", "R-MMU-8985947", "R-RNO-877300", "R-DRE-9732724", "R-SSC-9020591", "R-DRE-6783783", "R-DRE-1266695", "R-HSA-112411", "R-MMU-9020933", "R-SSC-6785807", "R-SSC-9732724", "R-RNO-9020956", "R-HSA-9670439", "R-RNO-9027276", "R-RNO-8983432", "R-RNO-912526", "R-HSA-9649948", "R-MMU-9020558", "R-DRE-877300", "R-SSC-877300", "R-RNO-5673001", "R-HSA-6783783", "R-HSA-1266695", "R-RNO-201556", "R-MMU-1433557", "R-RNO-9020933", "R-SSC-8984722", "R-MMU-982772", "R-RNO-8984722", "R-HSA-9020933", "R-DRE-8854691", "R-HSA-6785807", "R-HSA-8854691", "R-SSC-512988", "R-MMU-9705462", "R-HSA-5673001", "R-HSA-982772", "R-RNO-1433557", "R-MMU-9027276", "R-HSA-9674555", "R-DRE-6788467", "R-MMU-69231", "R-HSA-449836", "R-RNO-9674555", "R-MMU-112411", "R-RNO-1059683", "R-DRE-9705462", "R-HSA-1169408", "R-MMU-983231", "R-DRE-110056", "R-HSA-3214858", "R-MMU-9931295", "R-SSC-877312", "R-HSA-6802946", "R-RNO-110056", "R-HSA-912694", "R-MMU-6788467", "R-MMU-110056", "R-DRE-1059683", "R-MMU-8854691", "R-RNO-112411", "R-HSA-9020591", "R-MMU-1170546", "R-RNO-1266695", "R-SSC-9027276", "R-SSC-9020956", "R-MMU-8984722", "R-DRE-9020958", "R-RNO-982772", "R-HSA-9679191", "R-HSA-1433557", "R-MMU-1169408", "R-MMU-9006335", "R-MMU-877300", "R-RNO-8985947", "R-SSC-5673001", "R-MMU-1059683", "R-MMU-6783783", "R-HSA-9705462", "R-MMU-912694", "R-SSC-6788467"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-9020591:r:Interleukin-12 signaling", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-HSA-5673000:r:RAF activation", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-SSC-982772:r:Growth hormone receptor signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-2586552:r:Signaling by Leptin", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5673000:r:RAF activation", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5673000:r:RAF activation", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DRE-8983432:r:Interleukin-15 signaling", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DRE-877312:r:Regulation of IFNG signaling", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-201556:r:Signaling by ALK", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-SSC-9020591:r:Interleukin-12 signaling", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DRE-1266695:r:Interleukin-7 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-9020558:r:Interleukin-2 signaling", "R-DRE-877300:r:Interferon gamma signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-201556:r:Signaling by ALK", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-877312:r:Regulation of IFNG signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-DRE-1059683:r:Interleukin-6 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-RNO-1266695:r:Interleukin-7 signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-DRE-9020958:r:Interleukin-21 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Domain"}, "IPR041047": {"description": "Large polyvalent protein-associated domain 1", "go_ids": [], "go_terms": [], "name": "LPD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041048": {"description": "RuvB-like, AAA-lid domain", "go_ids": [], "go_terms": [], "name": "RuvB-like_C", "pathway_ids": ["R-DRE-5689880", "R-HSA-606279", "R-HSA-5689880", "R-RNO-606279", "R-DRE-201722", "R-MMU-606279", "R-CEL-201722", "R-DRE-5696394", "R-DME-5696394", "R-DME-201722", "R-RNO-5696394", "R-RNO-5689880", "R-HSA-171319", "R-CEL-5689880", "R-MMU-5689880", "R-RNO-5689603", "R-DRE-5689603", "R-HSA-201722", "R-DME-5689603", "R-HSA-5696394", "R-MMU-5696394", "R-MMU-5689603", "R-HSA-3214847", "R-HSA-5689603", "R-DME-5689880"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-5689603:r:UCH proteinases", "R-DRE-5689603:r:UCH proteinases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-5689603:r:UCH proteinases", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH proteinases", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-DME-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR041049": {"description": "Domain of unknown function DUF5615", "go_ids": [], "go_terms": [], "name": "DUF5615", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041050": {"description": "Pilin A4", "go_ids": [], "go_terms": [], "name": "PilA4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041051": {"description": "Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3", "go_ids": [], "go_terms": [], "name": "PCSK9_C3", "pathway_ids": ["PWY-7884", "R-RNO-381426", "R-HSA-381426", "R-HSA-8866427", "R-RNO-8957275", "R-MMU-8866427", "R-MMU-381426", "R-MMU-8964038", "R-HSA-8957275", "R-RNO-8964038", "R-RNO-8866427", "R-MMU-8957275", "R-HSA-8964038"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8964038:r:LDL clearance", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964038:r:LDL clearance"], "type": "Domain"}, "IPR041052": {"description": "Proprotein convertase subtilisin/kexin type 9, C-terminal domain 2", "go_ids": [], "go_terms": [], "name": "PCSK9_C2", "pathway_ids": ["PWY-7884", "R-RNO-381426", "R-HSA-381426", "R-HSA-8866427", "R-RNO-8957275", "R-MMU-8866427", "R-MMU-381426", "R-MMU-8964038", "R-HSA-8957275", "R-RNO-8964038", "R-RNO-8866427", "R-MMU-8957275", "R-HSA-8964038"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8964038:r:LDL clearance", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964038:r:LDL clearance"], "type": "Domain"}, "IPR041053": {"description": "Replicase polyprotein 1ab", "go_ids": [], "go_terms": [], "name": "Rep_1B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041054": {"description": "Exosome complex exonuclease Rrp40, N-terminal domain, eukaryotes", "go_ids": [], "go_terms": [], "name": "Rrp40_N_euk", "pathway_ids": ["R-SCE-429958", "R-DDI-429958", "R-SCE-6791226", "R-SPO-429958", "R-DDI-450385", "R-SCE-450513", "R-DDI-6791226", "R-DDI-450513", "R-SPO-9930044", "R-SPO-6791226", "R-DDI-9930044", "R-SCE-450385"], "pathways": ["R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DDI-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DDI-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-9930044:r:Nuclear RNA decay", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9930044:r:Nuclear RNA decay", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "type": "Domain"}, "IPR041055": {"description": "Serine/Threonine/Tyrosine Kinase found in polyvalent protein", "go_ids": [], "go_terms": [], "name": "Kinase-PolyVal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041056": {"description": "Protein of unknown function DUF5585", "go_ids": [], "go_terms": [], "name": "DUF5585", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041057": {"description": "ZHX, C2H2 finger domain", "go_ids": [], "go_terms": [], "name": "ZHX_Znf_C2H2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041058": {"description": "Alpha-(1,3)-fucosyltransferase FucT, N-terminal", "go_ids": [], "go_terms": [], "name": "FucT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041059": {"description": "Protein of of unknown function DUF5558", "go_ids": [], "go_terms": [], "name": "DUF5558", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041060": {"description": "RNA editing 3' terminal uridylyl transferase 2 middle domain", "go_ids": [], "go_terms": [], "name": "Ret2_MD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041061": {"description": "Dictyosteliid AID/APOBEC-like deaminase", "go_ids": [], "go_terms": [], "name": "DAAD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041062": {"description": "Csm1, subunit domain B", "go_ids": [], "go_terms": [], "name": "Csm1_B", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR041063": {"description": "Glycoside Hydrolase 20C, C-terminal", "go_ids": [], "go_terms": [], "name": "Glyco_H_20C_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041064": {"description": "Trehalose-6-phosphate phosphatase, helical bundle domain", "go_ids": [], "go_terms": [], "name": "T6PP_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041065": {"description": "GCN5-related N-acetyltransferase-like domain", "go_ids": [], "go_terms": [], "name": "GNAT-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041066": {"description": "C19orf38, Ig domain", "go_ids": [], "go_terms": [], "name": "C19orf38_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041067": {"description": "Vanadium chloroperoxidase, N-terminal", "go_ids": [], "go_terms": [], "name": "VCPO_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041068": {"description": "Methyltransferase, fungal type, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "HTH_51", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR041069": {"description": "FeoB, cytosolic helical domain", "go_ids": [], "go_terms": [], "name": "FeoB_Cyto", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR041070": {"description": "Jumonji, helical domain", "go_ids": [], "go_terms": [], "name": "JHD", "pathway_ids": ["R-DRE-3214842", "R-MMU-3214842", "R-HSA-6802952", "R-SPO-2299718", "R-HSA-3214842", "R-SPO-983168", "R-SPO-8951664", "R-HSA-2299718", "R-CEL-3214842", "R-DRE-2299718", "R-SPO-3214842"], "pathways": ["R-DRE-3214842:r:HDMs demethylate histones", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-SPO-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-3214842:r:HDMs demethylate histones", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-8951664:r:Neddylation", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-CEL-3214842:r:HDMs demethylate histones", "R-DRE-2299718:r:Condensation of Prophase Chromosomes", "R-SPO-3214842:r:HDMs demethylate histones"], "type": "Domain"}, "IPR041071": {"description": "DAHP synthase ferredoxin-like domain", "go_ids": [], "go_terms": [], "name": "DAHP_snth_FXD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041072": {"description": "Fumarylacetoacetase N-terminal domain", "go_ids": [], "go_terms": [], "name": "FAA_hydro_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041073": {"description": "MobL relaxases", "go_ids": [], "go_terms": [], "name": "MobL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041074": {"description": "Endo-beta-N-acetylglucosaminidase LytB, LytB SH3 domain", "go_ids": [], "go_terms": [], "name": "LytB_SH3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041075": {"description": "NOD1/2, winged helix domain", "go_ids": [], "go_terms": [], "name": "NOD1/2_WH", "pathway_ids": ["R-HSA-5689901", "R-HSA-1606341", "R-HSA-9020702", "R-HSA-9705671", "R-HSA-168638", "R-MMU-450302", "R-MMU-844455", "R-HSA-5689896", "R-MMU-5689901", "R-RNO-844455", "R-RNO-5689901", "R-MMU-5689896", "R-HSA-450321", "R-BTA-450321", "R-HSA-450302", "R-HSA-9707564", "R-MMU-168638", "R-BTA-168638", "R-HSA-844455", "R-BTA-5689901", "R-DRE-5689901", "R-HSA-3270619", "R-MMU-3270619", "R-BTA-5689896", "R-MMU-3134975", "R-HSA-9660826", "R-MMU-450321", "R-RNO-844456", "R-MMU-844456", "R-BTA-844456", "R-DRE-844456", "R-BTA-450302", "R-HSA-9692916", "R-HSA-3134975", "R-HSA-844456", "R-HSA-445989"], "pathways": ["R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-844455:r:The NLRP1 inflammasome", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689901:r:Metalloprotease DUBs", "R-RNO-844455:r:The NLRP1 inflammasome", "R-RNO-5689901:r:Metalloprotease DUBs", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-844455:r:The NLRP1 inflammasome", "R-BTA-5689901:r:Metalloprotease DUBs", "R-DRE-5689901:r:Metalloprotease DUBs", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-BTA-844456:r:The NLRP3 inflammasome", "R-DRE-844456:r:The NLRP3 inflammasome", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation"], "type": "Domain"}, "IPR041076": {"description": "Domain of unknown function DUF5614", "go_ids": [], "go_terms": [], "name": "DUF5614", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041077": {"description": "MALT1 immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "MALT1_Ig", "pathway_ids": ["R-HSA-2871837", "R-HSA-1169091", "R-MMU-202424", "R-MMU-2871837", "R-MMU-5607764", "R-HSA-5660668", "R-MMU-1169091", "R-HSA-202424", "R-HSA-5607764", "R-MMU-5660668"], "pathways": ["R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-5660668:r:CLEC7A/inflammasome pathway"], "type": "Domain"}, "IPR041078": {"description": "Plavaka transposase", "go_ids": [], "go_terms": [], "name": "Plavaka", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041079": {"description": "Neuraminidase-like domain", "go_ids": [], "go_terms": [], "name": "Neuraminidase-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041080": {"description": "YcaO cyclodehydratase, C-terminal", "go_ids": [], "go_terms": [], "name": "YcaO_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041081": {"description": "Domain of unknown function DUF5629", "go_ids": [], "go_terms": [], "name": "DUF5629", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041082": {"description": "Suv3, C-terminal domain 1", "go_ids": [], "go_terms": [], "name": "Suv3_C_1", "pathway_ids": ["R-HSA-9836573"], "pathways": ["R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Domain"}, "IPR041083": {"description": "AAA lid domain", "go_ids": [], "go_terms": [], "name": "AAA_lid_10", "pathway_ids": ["R-DDI-68689", "R-RNO-68949", "R-SPO-176187", "R-HSA-68949", "R-RNO-68962", "R-HSA-69205", "R-MMU-68962", "R-HSA-113507", "R-HSA-68867", "R-SPO-69017", "R-MMU-68949", "R-RNO-176187", "R-DDI-68616", "R-HSA-68689", "R-SCE-68962", "R-DME-68616", "R-SCE-68616", "R-DME-68689", "R-DME-68962", "R-HSA-68616", "R-DDI-68962", "R-RNO-68616", "R-SPO-68689", "R-SCE-68689", "R-SCE-68949", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949", "R-SCE-176187", "R-HSA-176187", "R-DME-68949", "R-RNO-68689", "R-DME-176187"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68949:r:Orc1 removal from chromatin", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68962:r:Activation of the pre-replicative complex", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68949:r:Orc1 removal from chromatin", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR041084": {"description": "Nicastrin, small lobe", "go_ids": [], "go_terms": [], "name": "Ncstrn_small", "pathway_ids": ["R-MMU-9839383", "R-HSA-6798695", "R-HSA-2122948", "R-MMU-3928665", "R-RNO-9017802", "R-CEL-6798695", "R-HSA-977225", "R-HSA-1251985", "R-RNO-193692", "R-CEL-1251985", "R-HSA-9017802", "R-MMU-193692", "R-HSA-2979096", "R-HSA-9013700", "R-MMU-9013507", "R-RNO-3928665", "R-RNO-205043", "R-DME-3928665", "R-HSA-9013507", "R-DME-1251985", "R-MMU-205043", "R-RNO-1251985", "R-HSA-1474228", "R-DDI-6798695", "R-DME-6798695", "R-HSA-205043", "R-HSA-2894862", "R-RNO-9839383", "R-RNO-9013507", "R-HSA-9839383", "R-MMU-9017802", "R-CEL-3928665", "R-MMU-1251985", "R-HSA-3928665", "R-MMU-6798695", "R-HSA-2644606", "R-HSA-193692", "R-RNO-6798695"], "pathways": ["R-MMU-9839383:r:TGFBR3 PTM regulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR041085": {"description": "tRNA selenocysteine 1-associated protein 1, C-terminal", "go_ids": [], "go_terms": [], "name": "TSAP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041086": {"description": "YAP binding domain", "go_ids": [], "go_terms": [], "name": "YBD", "pathway_ids": ["R-HSA-2032785", "R-HSA-9819196", "R-HSA-9909649", "R-CEL-2032785", "R-HSA-8951671", "R-DME-2032785", "R-MMU-8951671", "R-DME-390193", "R-HSA-9796292", "R-HSA-9619665", "R-MMU-2032785", "R-CEL-8951671", "R-DME-8951671"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-CEL-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-390193:r:Transcriptional activation by YKI", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-CEL-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-DME-8951671:r:RUNX3 regulates YAP1-mediated transcription"], "type": "Domain"}, "IPR041087": {"description": "TANK binding kinase 1, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "TBK1_ULD", "pathway_ids": ["R-HSA-1606341", "R-HSA-4755510", "R-HSA-9705671", "R-HSA-9920588", "R-HSA-168928", "R-HSA-9828211", "R-HSA-9824878", "R-HSA-936440", "R-MMU-5205685", "R-HSA-936964", "R-HSA-918233", "R-MMU-9008059", "R-HSA-5357905", "R-HSA-5205685", "R-MMU-9824878", "R-MMU-936964", "R-HSA-3270619", "R-MMU-5357786", "R-MMU-168928", "R-MMU-3270619", "R-HSA-9013973", "R-MMU-3134975", "R-HSA-9679191", "R-HSA-5357786", "R-HSA-9008059", "R-MMU-3249367", "R-HSA-933541", "R-HSA-9692916", "R-MMU-5357905", "R-HSA-3249367", "R-HSA-3134975", "R-MMU-936440", "R-HSA-9860927", "R-MMU-4755510", "R-MMU-9860927"], "pathways": ["R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-9008059:r:Interleukin-37 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "type": "Domain"}, "IPR041088": {"description": "Ribbon-helix-helix transcriptional regulator", "go_ids": [], "go_terms": [], "name": "RHH_8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041089": {"description": "SUB1 protease prodomain ProdP9", "go_ids": [], "go_terms": [], "name": "SUB1_ProdP9", "pathway_ids": ["R-PFA-2173796"], "pathways": ["R-PFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "type": "Domain"}, "IPR041090": {"description": "Protein of unknown function DUF5578", "go_ids": [], "go_terms": [], "name": "DUF5578", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041091": {"description": "RPGRIP1, C-terminal", "go_ids": [], "go_terms": [], "name": "RPGRIP1_C", "pathway_ids": ["R-HSA-5610787", "R-MMU-5610787", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR041092": {"description": "Phage-Barnase-EndoU-ColicinE5/D-RelE-like nuclease", "go_ids": [], "go_terms": [], "name": "PBECR1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041093": {"description": "DIS3-like exonuclease 2-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Dis3l2-like_C", "pathway_ids": ["R-HSA-9820865"], "pathways": ["R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors"], "type": "Domain"}, "IPR041094": {"description": "Brr2, N-terminal helicase PWI domain", "go_ids": [], "go_terms": [], "name": "Brr2_helicase_PWI", "pathway_ids": ["R-HSA-72163", "R-DME-72165", "R-MMU-72165", "R-RNO-72165", "R-CEL-72165", "R-MMU-72163", "R-HSA-72165", "R-RNO-72163", "R-DME-72163", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR041095": {"description": "Elongation Factor G, domain II", "go_ids": [], "go_terms": [], "name": "EFG_II", "pathway_ids": ["R-DME-5358493", "R-HSA-6798695", "R-SCE-8876725", "R-SPO-6798695", "R-HSA-8876725", "R-HSA-5419276", "R-RNO-5358493", "R-CEL-156902", "R-CEL-6798695", "R-SCE-6798695", "R-BTA-6798695", "R-BTA-5358493", "R-DRE-156902", "R-DME-156902", "R-SPO-156902", "R-SPO-5358493", "R-HSA-5336415", "R-RNO-5419276", "R-DRE-6798695", "R-HSA-72165", "R-HSA-5389840", "R-DDI-156902", "R-HSA-9918481", "R-BTA-8876725", "R-RNO-5389840", "R-DRE-5419276", "R-DRE-5358493", "R-DDI-6798695", "R-RNO-156902", "R-SCE-5358493", "R-CEL-5358493", "R-CEL-5389840", "R-MMU-72163", "R-DME-6798695", "R-HSA-156902", "R-CEL-8876725", "R-SPO-8876725", "R-DRE-5389840", "R-DDI-8876725", "R-MMU-156902", "R-MMU-8876725", "R-DME-8876725", "R-HSA-72163", "R-DRE-8876725", "R-MMU-5358493", "R-MMU-72165", "R-SCE-156902", "R-BTA-156902", "R-HSA-5358493", "R-RNO-8876725", "R-MMU-5419276", "R-MMU-6798695", "R-BTA-5419276", "R-DME-5419276", "R-DME-5389840", "R-DDI-5358493", "R-MMU-5389840", "R-RNO-6798695"], "pathways": ["R-DME-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-8876725:r:Protein methylation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-8876725:r:Protein methylation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-RNO-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-156902:r:Peptide chain elongation", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-156902:r:Peptide chain elongation", "R-DME-156902:r:Peptide chain elongation", "R-SPO-156902:r:Peptide chain elongation", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-RNO-5419276:r:Mitochondrial translation termination", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DDI-156902:r:Peptide chain elongation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-8876725:r:Protein methylation", "R-RNO-5389840:r:Mitochondrial translation elongation", "R-DRE-5419276:r:Mitochondrial translation termination", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-156902:r:Peptide chain elongation", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-156902:r:Peptide chain elongation", "R-CEL-8876725:r:Protein methylation", "R-SPO-8876725:r:Protein methylation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-DDI-8876725:r:Protein methylation", "R-MMU-156902:r:Peptide chain elongation", "R-MMU-8876725:r:Protein methylation", "R-DME-8876725:r:Protein methylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-8876725:r:Protein methylation", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-156902:r:Peptide chain elongation", "R-BTA-156902:r:Peptide chain elongation", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-RNO-8876725:r:Protein methylation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR041097": {"description": "PKHD-type hydroxylase C-terminal domain", "go_ids": [], "go_terms": [], "name": "PKHD_C", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis"], "type": "Domain"}, "IPR041098": {"description": "Rv2175c, C-terminal", "go_ids": [], "go_terms": [], "name": "Rv2175c_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041099": {"description": "Fatty acid synthase subunit beta, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FAS1_N", "pathway_ids": ["PWY-8174", "PWY-5147", "PWY-5142", "PWY-8427", "PWY-6799", "PWY-8280", "PWY-6519", "PWY-8203", "PWY-7663", "PWY-5367", "PWY-7746", "PWY-8438", "PWY-5989", "PWY-4381", "PWY-5966", "PWY-7723", "PWY-8012", "PWY-5971", "PWY-8173", "PWY-6113", "PWY-5366", "PWY-7664", "PWY-8175", "PWY-7858", "PWY-8049", "PWYG-321", "PWY-7388", "PWY-5994", "PWY-5973", "PWY-8279", "PWY-8047", "PWY-6282"], "pathways": ["PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-5147:t:oleate biosynthesis I (plants)", "PWY-5142:t:acyl-[acyl-carrier protein] thioesterase pathway", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWY-5367:t:petroselinate biosynthesis", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-7723:t:bacterial bioluminescence", "PWY-8012:t:mupirocin biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "PWY-6113:t:superpathway of mycolate biosynthesis", "PWY-5366:t:palmitoleate biosynthesis II (plants and bacteria)", "PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8049:t:pederin biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8279:t:palmitate biosynthesis III", "PWY-8047:t:bryostatin biosynthesis", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"], "type": "Domain"}, "IPR041100": {"description": "T-Q ester bond containing domain", "go_ids": [], "go_terms": [], "name": "TQ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041101": {"description": "Transport inhibitor response 1 domain", "go_ids": [], "go_terms": [], "name": "Transp_inhibit", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041102": {"description": "UvrA, UvrB Binding Domain", "go_ids": [], "go_terms": [], "name": "UvrA_UBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041103": {"description": "Glutamate--tRNA ligase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GluRS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041104": {"description": "DNA processing protein A, sterile alpha motif domain", "go_ids": [], "go_terms": [], "name": "SAM_DprA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041105": {"description": "TAR DNA-binding protein 43, N-terminal", "go_ids": [], "go_terms": [], "name": "TDP-43_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041106": {"description": "Exoribonuclease Xrn1, D2/D3 domain", "go_ids": [], "go_terms": [], "name": "XRN1_D2_D3", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-MMU-450513", "R-HSA-450513", "R-SCE-450513", "R-HSA-9918487", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR041107": {"description": "RimK, preATP-grasp domain", "go_ids": [], "go_terms": [], "name": "Rimk_N", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis"], "type": "Domain"}, "IPR041108": {"description": "Polyphosphate kinase, C-terminal domain 1", "go_ids": [], "go_terms": [], "name": "PP_kinase_C_1", "pathway_ids": ["PWY-8138"], "pathways": ["PWY-8138:t:polyphosphate metabolism"], "type": "Domain"}, "IPR041109": {"description": "HMW1C N-terminal", "go_ids": [], "go_terms": [], "name": "HMW1C_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041110": {"description": "Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 2", "go_ids": [], "go_terms": [], "name": "PBECR2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041111": {"description": "Pullulanase, Ins domain", "go_ids": [], "go_terms": [], "name": "Pullulanase_Ins", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041112": {"description": "Nuf2, DHR10-like domain", "go_ids": [], "go_terms": [], "name": "Nuf2_DHR10-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041113": {"description": "Heliorhodopsin", "go_ids": [], "go_terms": [], "name": "Heliorhodopsin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041114": {"description": "Nitrous oxide reductase, propeller repeat 1", "go_ids": [], "go_terms": [], "name": "Nos_propeller", "pathway_ids": ["PWY-7084", "PWY-6748"], "pathways": ["PWY-7084:t:nitrifier denitrification", "PWY-6748:t:nitrate reduction VII (denitrification)"], "type": "Repeat"}, "IPR041115": {"description": "SMODS and SLOG-associating 2TM effector domain 5", "go_ids": [], "go_terms": [], "name": "SLATT_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041116": {"description": "SMODS and SLOG-associating 2TM effector domain 3", "go_ids": [], "go_terms": [], "name": "SLATT_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041117": {"description": "SoxA, A3 domain", "go_ids": [], "go_terms": [], "name": "SoxA_A3", "pathway_ids": ["PWY-3661"], "pathways": ["PWY-3661:t:glycine betaine degradation I"], "type": "Domain"}, "IPR041118": {"description": "Disease resistance, N-terminal", "go_ids": [], "go_terms": [], "name": "Rx_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041119": {"description": "SMODS and SLOG-associating 2TM effector domain 6", "go_ids": [], "go_terms": [], "name": "SLATT_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041120": {"description": "VapC9 PIN-like domain", "go_ids": [], "go_terms": [], "name": "PIN_9", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041121": {"description": "SDH, C-terminal", "go_ids": [], "go_terms": [], "name": "SDH_C", "pathway_ids": ["PWY-6163"], "pathways": ["PWY-6163:t:chorismate biosynthesis from 3-dehydroquinate"], "type": "Domain"}, "IPR041122": {"description": "RecJ, OB domain", "go_ids": [], "go_terms": [], "name": "RecJ_OB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041123": {"description": "Chromosome region maintenance repeat", "go_ids": [], "go_terms": [], "name": "CRM1_repeat", "pathway_ids": ["R-MMU-9856649", "R-DME-69273", "R-DME-9634638", "R-HSA-2467813", "R-HSA-3769402", "R-SPO-5687128", "R-DME-9707616", "R-RNO-2500257", "R-MMU-2467813", "R-SCE-9856649", "R-HSA-69273", "R-RNO-450520", "R-RNO-5687128", "R-MMU-68877", "R-RNO-9634638", "R-HSA-168333", "R-HSA-9828806", "R-HSA-68877", "R-MMU-9707616", "R-HSA-165054", "R-RNO-9707616", "R-RNO-141444", "R-MMU-9648025", "R-MMU-2500257", "R-MMU-3769402", "R-RNO-68877", "R-HSA-2500257", "R-DDI-5687128", "R-MMU-141444", "R-RNO-9856649", "R-HSA-9918432", "R-DME-9856649", "R-HSA-141444", "R-HSA-450520", "R-HSA-9707616", "R-MMU-450520", "R-HSA-9648025", "R-DME-450520", "R-HSA-9634638", "R-RNO-5663220", "R-RNO-69273", "R-DME-3769402", "R-HSA-5687128", "R-HSA-9856649", "R-HSA-5663220", "R-MMU-9634638", "R-MMU-5687128", "R-SCE-5687128", "R-MMU-69273", "R-HSA-2173788", "R-RNO-9648025", "R-RNO-2467813", "R-RNO-3769402", "R-MMU-5663220", "R-HSA-9768919"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-DME-9707616:r:Heme signaling", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-9707616:r:Heme signaling", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-9707616:r:Heme signaling", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9707616:r:Heme signaling", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Repeat"}, "IPR041124": {"description": "Sensor histidine kinase (AbfS), sensor domain", "go_ids": [], "go_terms": [], "name": "AbfS_sensor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041125": {"description": "4-hydroxyphenylacetate decarboxylase small gamma subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "4HPAD_g_N", "pathway_ids": ["PWY-7514"], "pathways": ["PWY-7514:t:L-tyrosine degradation IV (to 4-methylphenol)"], "type": "Domain"}, "IPR041126": {"description": "Chlamydial protease/proteasome-like activity factor, PDZ domain", "go_ids": [], "go_terms": [], "name": "CPAF_PDZ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041127": {"description": "PET hydrolase/cutinase-like", "go_ids": [], "go_terms": [], "name": "PET_hydrolase/cutinase-like", "pathway_ids": ["PWY-7794"], "pathways": ["PWY-7794:t:polyethylene terephthalate degradation"], "type": "Domain"}, "IPR041128": {"description": "Arginine decarboxylase, C-terminal helical", "go_ids": [], "go_terms": [], "name": "Arg_decarbox_C", "pathway_ids": ["PWY-40", "PWY-43", "PWY-6834"], "pathways": ["PWY-40:t:putrescine biosynthesis I", "PWY-43:t:putrescine biosynthesis II", "PWY-6834:t:spermidine biosynthesis III"], "type": "Domain"}, "IPR041129": {"description": "CdiI immunity protein", "go_ids": [], "go_terms": [], "name": "CdiI_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041131": {"description": "Phage MuF, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MuF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041132": {"description": "Domain of unknown function DUF5624", "go_ids": [], "go_terms": [], "name": "DUF5624", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041134": {"description": "Major vault protein repeat domain 2", "go_ids": [], "go_terms": [], "name": "Vault_2", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR041135": {"description": "Nucleotide modification associated domain 3", "go_ids": [], "go_terms": [], "name": "Nmad3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041136": {"description": "Major vault protein repeat domain 4", "go_ids": [], "go_terms": [], "name": "Vault_4", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR041137": {"description": "Zinc transporter ZIP4, N-terminal", "go_ids": [], "go_terms": [], "name": "ZIP4_N", "pathway_ids": ["R-HSA-5619088", "R-MMU-442380", "R-HSA-442380", "R-BTA-442380", "R-RNO-442380"], "pathways": ["R-HSA-5619088:r:Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)", "R-MMU-442380:r:Zinc influx into cells by the SLC39 gene family", "R-HSA-442380:r:Zinc influx into cells by the SLC39 gene family", "R-BTA-442380:r:Zinc influx into cells by the SLC39 gene family", "R-RNO-442380:r:Zinc influx into cells by the SLC39 gene family"], "type": "Domain"}, "IPR041139": {"description": "Major vault protein repeat domain", "go_ids": [], "go_terms": [], "name": "MVP_rep_dom", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR041140": {"description": "Defence against restriction A, N-terminal", "go_ids": [], "go_terms": [], "name": "DarA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041141": {"description": "Diiron non-heme beta-hydroxylase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CmlA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041142": {"description": "Nitrous oxide reductase, propeller repeat 2", "go_ids": [], "go_terms": [], "name": "NOS_propeller_2", "pathway_ids": ["PWY-7084", "PWY-6748"], "pathways": ["PWY-7084:t:nitrifier denitrification", "PWY-6748:t:nitrate reduction VII (denitrification)"], "type": "Repeat"}, "IPR041143": {"description": "YgxA-like, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "YgxA_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041144": {"description": "Stomatal closure-related actin-binding protein, PH domain", "go_ids": [], "go_terms": [], "name": "SCAB-PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041145": {"description": "Domain of unknown function DUF5619", "go_ids": [], "go_terms": [], "name": "DUF5619", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041146": {"description": "IFT81, calponin homology domain", "go_ids": [], "go_terms": [], "name": "IFT81_CH", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR041147": {"description": "Glycosyl hydrolases family 38, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GH38_C", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-MMU-8853383", "R-RNO-8853383", "R-BTA-8853383", "R-HSA-8853383", "R-SPO-8853383", "R-MMU-6798695", "R-BTA-6798695", "R-DDI-8853383", "R-SCE-8853383"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-BTA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-SPO-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-8853383:r:Lysosomal oligosaccharide catabolism", "R-SCE-8853383:r:Lysosomal oligosaccharide catabolism"], "type": "Domain"}, "IPR041149": {"description": "Extracellular cadherin domain", "go_ids": [], "go_terms": [], "name": "EC_dom", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR041150": {"description": "Chromodomain helicase DNA-binding domain", "go_ids": [], "go_terms": [], "name": "Cdh1_DBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041151": {"description": "Replication initiator protein A, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Bac_RepA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041152": {"description": "Oligosaccharyltransferase, peripheral 2 domain", "go_ids": [], "go_terms": [], "name": "OST_P2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041153": {"description": "LST4, longin domain", "go_ids": [], "go_terms": [], "name": "LST4_longin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041154": {"description": "Archaeal glycosylation protein B, peripheral domain", "go_ids": [], "go_terms": [], "name": "AglB_P1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041155": {"description": "FERM F1 lobe ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "FERM_F1", "pathway_ids": ["R-SSC-5673000", "R-RNO-6785807", "R-HSA-9020958", "R-HSA-6802952", "R-MMU-1266695", "R-HSA-9006335", "R-MMU-9674555", "R-RNO-9020558", "R-RNO-9020591", "R-SSC-912526", "R-SSC-69231", "R-HSA-9732724", "R-HSA-69231", "R-HSA-9027284", "R-RNO-512988", "R-RNO-8854691", "R-RNO-877312", "R-SSC-9020933", "R-MMU-9020958", "R-MMU-201556", "R-HSA-5673000", "R-MMU-9732724", "R-RNO-983231", "R-SSC-112411", "R-SSC-982772", "R-HSA-512988", "R-SSC-9705462", "R-SSC-1170546", "R-MMU-909733", "R-HSA-6802955", "R-HSA-2586552", "R-SSC-9674555", "R-HSA-9027283", "R-HSA-8984722", "R-MMU-5673001", "R-HSA-9931295", "R-RNO-5673000", "R-DRE-112411", "R-HSA-1170546", "R-RNO-9732724", "R-HSA-983231", "R-MMU-5673000", "R-RNO-9705462", "R-DRE-909733", "R-DRE-912694", "R-HSA-8983432", "R-SSC-9027284", "R-RNO-9020958", "R-MMU-912526", "R-DRE-6785807", "R-RNO-9006335", "R-HSA-909733", "R-DRE-8983432", "R-SSC-1433557", "R-HSA-8985947", "R-MMU-6785807", "R-HSA-9656223", "R-HSA-9833109", "R-HSA-9705671", "R-HSA-1059683", "R-DRE-877312", "R-MMU-9020956", "R-HSA-6788467", "R-SSC-8854691", "R-RNO-9027284", "R-MMU-9020591", "R-HSA-877312", "R-MMU-512988", "R-RNO-6788467", "R-HSA-9027276", "R-MMU-877312", "R-HSA-9020558", "R-MMU-9027284", "R-RNO-1170546", "R-SSC-1059683", "R-SSC-9006335", "R-MMU-8983432", "R-HSA-110056", "R-RNO-69231", "R-HSA-912526", "R-HSA-877300", "R-SSC-983231", "R-HSA-201556", "R-HSA-9027277", "R-HSA-9725370", "R-HSA-9020956", "R-MMU-8985947", "R-RNO-877300", "R-DRE-9732724", "R-SSC-9020591", "R-DRE-6783783", "R-DRE-1266695", "R-HSA-112411", "R-MMU-9020933", "R-SSC-6785807", "R-SSC-9732724", "R-RNO-9020956", "R-HSA-9670439", "R-RNO-9027276", "R-RNO-8983432", "R-RNO-912526", "R-HSA-9649948", "R-MMU-9020558", "R-DRE-877300", "R-SSC-877300", "R-RNO-5673001", "R-HSA-6783783", "R-HSA-1266695", "R-RNO-201556", "R-MMU-1433557", "R-RNO-9020933", "R-SSC-8984722", "R-MMU-982772", "R-RNO-8984722", "R-HSA-9020933", "R-DRE-8854691", "R-HSA-6785807", "R-HSA-8854691", "R-SSC-512988", "R-MMU-9705462", "R-HSA-5673001", "R-HSA-982772", "R-RNO-1433557", "R-MMU-9027276", "R-HSA-9674555", "R-DRE-6788467", "R-MMU-69231", "R-HSA-449836", "R-RNO-9674555", "R-MMU-112411", "R-RNO-1059683", "R-DRE-9705462", "R-HSA-1169408", "R-MMU-983231", "R-DRE-110056", "R-HSA-3214858", "R-MMU-9931295", "R-SSC-877312", "R-HSA-6802946", "R-RNO-110056", "R-HSA-912694", "R-MMU-6788467", "R-MMU-110056", "R-DRE-1059683", "R-MMU-8854691", "R-RNO-112411", "R-HSA-9020591", "R-MMU-1170546", "R-RNO-1266695", "R-SSC-9027276", "R-SSC-9020956", "R-MMU-8984722", "R-DRE-9020958", "R-RNO-982772", "R-HSA-9679191", "R-HSA-1433557", "R-MMU-1169408", "R-MMU-9006335", "R-MMU-877300", "R-RNO-8985947", "R-SSC-5673001", "R-MMU-1059683", "R-MMU-6783783", "R-HSA-9705462", "R-MMU-912694", "R-SSC-6788467"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-9020591:r:Interleukin-12 signaling", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-HSA-5673000:r:RAF activation", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-SSC-982772:r:Growth hormone receptor signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-2586552:r:Signaling by Leptin", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5673000:r:RAF activation", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5673000:r:RAF activation", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DRE-8983432:r:Interleukin-15 signaling", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DRE-877312:r:Regulation of IFNG signaling", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-201556:r:Signaling by ALK", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-SSC-9020591:r:Interleukin-12 signaling", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DRE-1266695:r:Interleukin-7 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-9020558:r:Interleukin-2 signaling", "R-DRE-877300:r:Interferon gamma signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-201556:r:Signaling by ALK", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-877312:r:Regulation of IFNG signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-DRE-1059683:r:Interleukin-6 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-RNO-1266695:r:Interleukin-7 signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-DRE-9020958:r:Interleukin-21 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Domain"}, "IPR041156": {"description": "Transmembrane protein 250", "go_ids": [], "go_terms": [], "name": "TM250", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041157": {"description": "Up-regulated in Daf-2", "go_ids": [], "go_terms": [], "name": "PUD1/2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041158": {"description": "Cue1, Ubc7p-binding domain", "go_ids": [], "go_terms": [], "name": "Cue1_U7BR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041160": {"description": "SLOG cluster2", "go_ids": [], "go_terms": [], "name": "LD_cluster2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041161": {"description": "Tenascin, EGF-like domain", "go_ids": [], "go_terms": [], "name": "EGF_Tenascin", "pathway_ids": ["R-HSA-216083", "R-HSA-3000170", "R-MMU-3000178", "R-MMU-381426", "R-HSA-3000178", "R-MMU-216083", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-3000178:r:ECM proteoglycans", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR041162": {"description": "Bacterial HORMA domain 1", "go_ids": [], "go_terms": [], "name": "Bact_HORMA_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041163": {"description": "Ret, cadherin like domain 1", "go_ids": [], "go_terms": [], "name": "Ret_CLD1", "pathway_ids": ["R-HSA-9830674", "R-HSA-8853659", "R-RNO-8853659", "R-HSA-9830364", "R-MMU-8853659", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-9768919", "R-HSA-5673001"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8853659:r:RET signaling", "R-RNO-8853659:r:RET signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-MMU-8853659:r:RET signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Domain"}, "IPR041164": {"description": "AF_1126-like", "go_ids": [], "go_terms": [], "name": "AF_112-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041165": {"description": "Cas6, N-terminal domain, archaea", "go_ids": [], "go_terms": [], "name": "Cas6_N_arch", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041166": {"description": "LapB, rubredoxin metal binding domain", "go_ids": [], "go_terms": [], "name": "Rubredoxin_2", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR041167": {"description": "SAVED-fused 2TM effector domain", "go_ids": [], "go_terms": [], "name": "Saf_2TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041168": {"description": "L-Lysine epsilon oxidase, N-terminal", "go_ids": [], "go_terms": [], "name": "LodA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041169": {"description": "Alpha helical domain", "go_ids": [], "go_terms": [], "name": "Alpha_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041170": {"description": "RING/Ubox-like zinc-binding domain", "go_ids": [], "go_terms": [], "name": "Znf-RING_14", "pathway_ids": ["R-DME-983168", "R-HSA-9646399", "R-RNO-5205685", "R-HSA-5689877", "R-HSA-977225", "R-HSA-5675482", "R-DME-5689877", "R-MMU-5675482", "R-DME-9646399", "R-HSA-983168", "R-MMU-5205685", "R-MMU-9646399", "R-MMU-5689877", "R-DME-5205685", "R-RNO-5689877", "R-MMU-983168", "R-RNO-9646399", "R-RNO-5675482", "R-HSA-5205685", "R-RNO-983168"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9646399:r:Aggrephagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5689877:r:Josephin domain DUBs", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-DME-5689877:r:Josephin domain DUBs", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DME-9646399:r:Aggrephagy", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-9646399:r:Aggrephagy", "R-MMU-5689877:r:Josephin domain DUBs", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-5689877:r:Josephin domain DUBs", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR041171": {"description": "SDR-like Ig domain", "go_ids": [], "go_terms": [], "name": "SDR_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041172": {"description": "Esterase, Ig-like N-terminal", "go_ids": [], "go_terms": [], "name": "EstA_Ig-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041173": {"description": "L-lysine epsilon oxidase, C-terminal", "go_ids": [], "go_terms": [], "name": "LodA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041174": {"description": "KRR1 small subunit processome component, first KH domain", "go_ids": [], "go_terms": [], "name": "KRR1-like_KH1", "pathway_ids": ["R-BTA-6791226", "R-DME-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR041175": {"description": "VLRF1/Vms1", "go_ids": [], "go_terms": [], "name": "VLRF1/Vms1", "pathway_ids": ["R-HSA-9954709"], "pathways": ["R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR041176": {"description": "von Willebrand factor type A, C-terminal domain", "go_ids": [], "go_terms": [], "name": "VWA_3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041177": {"description": "Holliday junction resolvase Gen1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GEN1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041178": {"description": "RPA43, OB domain", "go_ids": [], "go_terms": [], "name": "RPA43_OB", "pathway_ids": ["R-DRE-73863", "R-HSA-73772", "R-HSA-73863", "R-MMU-5250924", "R-SPO-73772", "R-SCE-73762", "R-MMU-73762", "R-DRE-73772", "R-DRE-73762", "R-HSA-5250924", "R-HSA-427413", "R-MMU-73863", "R-MMU-73772", "R-HSA-73762", "R-SCE-73772", "R-DRE-5250924", "R-SPO-73762"], "pathways": ["R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Domain"}, "IPR041179": {"description": "Centrosomal protein C10orf90, N-terminal", "go_ids": [], "go_terms": [], "name": "C10orf90_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041180": {"description": "Nucleotide modification associated domain 2", "go_ids": [], "go_terms": [], "name": "Nmad2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041181": {"description": "DR2241 stabilising domain", "go_ids": [], "go_terms": [], "name": "DR2241_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041182": {"description": "Leptin receptor, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "LEP-R_IGD", "pathway_ids": ["R-HSA-2586552"], "pathways": ["R-HSA-2586552:r:Signaling by Leptin"], "type": "Domain"}, "IPR041183": {"description": "Cyclophilin-like", "go_ids": [], "go_terms": [], "name": "Cyclophilin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041184": {"description": "T6 antigen, Ig-like domain", "go_ids": [], "go_terms": [], "name": "T6_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041185": {"description": "IKBKB, scaffold dimerization domain", "go_ids": [], "go_terms": [], "name": "IKBKB_SDD", "pathway_ids": ["R-BTA-9909505", "R-MMU-9909505", "R-HSA-9020702", "R-RNO-9758274", "R-DRE-1169091", "R-RNO-9020702", "R-HSA-168638", "R-MMU-5607764", "R-HSA-9833482", "R-XTR-5357905", "R-XTR-5607764", "R-MMU-198323", "R-BTA-202424", "R-MMU-9020702", "R-XTR-202424", "R-HSA-5676590", "R-BTA-975144", "R-RNO-5357905", "R-MMU-933542", "R-DRE-198323", "R-DRE-445989", "R-MMU-9833482", "R-HSA-5684264", "R-MMU-445989", "R-BTA-9758274", "R-HSA-168927", "R-BTA-1169091", "R-XTR-5607761", "R-MMU-1810476", "R-BTA-937041", "R-RNO-202424", "R-HSA-937041", "R-DRE-9020702", "R-BTA-5607761", "R-GGA-1227892", "R-MMU-5684264", "R-HSA-5603029", "R-HSA-5607761", "R-MMU-975144", "R-XTR-5684264", "R-HSA-209560", "R-BTA-5357905", "R-MMU-209543", "R-HSA-975144", "R-HSA-5674400", "R-RNO-975144", "R-RNO-209560", "R-HSA-9758274", "R-GGA-434131", "R-BTA-5684264", "R-MMU-9860276", "R-HSA-5602636", "R-RNO-209543", "R-HSA-9860276", "R-HSA-1169091", "R-DRE-5357905", "R-DRE-5684264", "R-BTA-1810476", "R-MMU-2871837", "R-BTA-933542", "R-MMU-5357905", "R-RNO-445989", "R-HSA-1236974", "R-DRE-5607761", "R-HSA-9860927", "R-BTA-937039", "R-BTA-9833482", "R-DRE-937039", "R-MMU-9860927", "R-RNO-933542", "R-HSA-445989", "R-HSA-9705671", "R-RNO-9860276", "R-BTA-5357956", "R-RNO-9833482", "R-HSA-209543", "R-HSA-933542", "R-RNO-9909505", "R-MMU-5357956", "R-BTA-5676590", "R-DRE-9833482", "R-HSA-9909505", "R-HSA-198323", "R-RNO-9860927", "R-HSA-2871837", "R-BTA-2871837", "R-HSA-5357905", "R-MMU-937039", "R-BTA-209543", "R-BTA-445989", "R-DRE-5676590", "R-XTR-445989", "R-HSA-5607764", "R-BTA-209560", "R-XTR-9758274", "R-RNO-1810476", "R-MMU-202424", "R-RNO-937039", "R-RNO-937041", "R-XTR-2871837", "R-GGA-1227739", "R-RNO-2871837", "R-MMU-209560", "R-RNO-5684264", "R-BTA-9860276", "R-MMU-1169091", "R-GGA-434001", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-1810476", "R-BTA-9860927", "R-XTR-9833482", "R-HSA-5603027", "R-DRE-975144", "R-HSA-5357956", "R-RNO-5607764", "R-RNO-1169091", "R-HSA-933543", "R-BTA-9020702", "R-BTA-5607764", "R-RNO-5357956", "R-MMU-9758274", "R-HSA-202424", "R-MMU-937041", "R-DRE-9758274", "R-HSA-937039", "R-XTR-5676590", "R-XTR-1169091"], "pathways": ["R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-XTR-5357905:r:Regulation of TNFR1 signaling", "R-XTR-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-XTR-202424:r:Downstream TCR signaling", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-XTR-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DRE-9020702:r:Interleukin-1 signaling", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-XTR-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-5602636:r:IKBKB deficiency causes SCID", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-BTA-9833482:r:PKR-mediated signaling", "R-DRE-937039:r:IRAK1 recruits IKK complex", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-9833482:r:PKR-mediated signaling", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-XTR-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-GGA-1227739:r:Caspase-8 and -10 mediated induction of NF-kB", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-XTR-9833482:r:PKR-mediated signaling", "R-HSA-5603027:r:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "R-DRE-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-DRE-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-XTR-5676590:r:NIK-->noncanonical NF-kB signaling", "R-XTR-1169091:r:Activation of NF-kappaB in B cells"], "type": "Domain"}, "IPR041186": {"description": "Domain of unknown function DUF3823_C", "go_ids": [], "go_terms": [], "name": "DUF3823_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041188": {"description": "ARS-binding protein 1, N-terminal", "go_ids": [], "go_terms": [], "name": "HTH_ABP1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041189": {"description": "Transcription factor IIB, C-terminal module 1", "go_ids": [], "go_terms": [], "name": "TFIIB_C_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041190": {"description": "Midasin AAA lid domain 5", "go_ids": [], "go_terms": [], "name": "Midasin_AAA_lid_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041191": {"description": "pPIWI_RE three-gene island domain Y", "go_ids": [], "go_terms": [], "name": "pPIWI_RE_Y", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041192": {"description": "ZNF451, PIN-like domain", "go_ids": [], "go_terms": [], "name": "PIN_11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041193": {"description": "CysA, C-terminal regulatory domain", "go_ids": [], "go_terms": [], "name": "CysA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041194": {"description": "Defective in germ line development protein 3-like, KH5 domain", "go_ids": [], "go_terms": [], "name": "GLD-3-like_KH5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041195": {"description": "Rnh202, triple barrel domain", "go_ids": [], "go_terms": [], "name": "Rnh202_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041196": {"description": "Large polyvalent protein associated domain 37", "go_ids": [], "go_terms": [], "name": "LPD37", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041197": {"description": "SLOG cluster3 family", "go_ids": [], "go_terms": [], "name": "LD_cluster3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041198": {"description": "N-terminal extension of GAT domain", "go_ids": [], "go_terms": [], "name": "GGA_N-GAT", "pathway_ids": ["R-HSA-8875656", "R-RNO-8875656", "R-HSA-8854214", "R-MMU-8875656", "R-HSA-977225"], "pathways": ["R-HSA-8875656:r:MET receptor recycling", "R-RNO-8875656:r:MET receptor recycling", "R-HSA-8854214:r:TBC/RABGAPs", "R-MMU-8875656:r:MET receptor recycling", "R-HSA-977225:r:Amyloid fiber formation"], "type": "Domain"}, "IPR041199": {"description": "CarS, SH3 domain", "go_ids": [], "go_terms": [], "name": "CarS_SH3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041200": {"description": "FKBP3, basic tilted helix bundle domain", "go_ids": [], "go_terms": [], "name": "FKBP3_BTHB", "pathway_ids": ["R-HSA-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR041201": {"description": "PTPRJ, transmembrane domain", "go_ids": [], "go_terms": [], "name": "PTPRJ_TM", "pathway_ids": ["R-HSA-6798695", "R-HSA-202427", "R-CEL-6798695", "R-MMU-6798695", "R-MMU-9706369", "R-MMU-202427", "R-MMU-6807004", "R-HSA-6807004", "R-HSA-9706369"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9706369:r:Negative regulation of FLT3", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-9706369:r:Negative regulation of FLT3"], "type": "Domain"}, "IPR041202": {"description": "Bacterial archaeo-eukaryotic 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"R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-936440:r:Negative regulators of 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{"description": "Domain of unknown function DUF5606", "go_ids": [], "go_terms": [], "name": "DUF5606", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041219": {"description": "Phage tail lysozyme", "go_ids": [], "go_terms": [], "name": "Phage_lysozyme2", "pathway_ids": ["PWY-7529", "PWY-6848", "PWY-7134", "PWY-8435", "PWY-1921", "PWY-7133", "PWY-6784", "PWY-8436", "PWY-7091", "PWY-7074", "PWY-6527", "PWY-6717", "PWY-7647", "PWY-6972", "PWY-8366", "PWY-5976", "PWY-6821", "PWY-6735", "PWY-6906", "PWY-6855", "PWY-7491", "PWY-7057", "PWY-842", "PWY-862", "PWY-6737", "PWY-7445", "PWY-5821", "PWY-6749", "PWY-7056", "PWY-7256"], "pathways": ["PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6848:t:rutin degradation", "PWY-7134:t:rutin degradation (plants)", "PWY-8435:t:yeast mannan degradation", "PWY-1921:t:indole-3-acetate activation II", "PWY-7133:t:quercetin glucoside degradation (Allium)", "PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)", "PWY-8436:t:mammalian high-mannose N-glycan degradation", "PWY-7091:t:linustatin bioactivation", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-6527:t:stachyose degradation", "PWY-6717:t:(1,4)-beta-D-xylan degradation", "PWY-7647:t:ulvan degradation", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8366:t:septacidin biosynthesis", "PWY-5976:t:dhurrin degradation", "PWY-6821:t:kappa-carrageenan degradation", "PWY-6735:t:starch degradation IV", "PWY-6906:t:chitin derivatives degradation", "PWY-6855:t:chitin degradation I (archaea)", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7057:t:cichoriin interconversion", "PWY-842:t:starch degradation I", "PWY-862:t:fructan degradation", "PWY-6737:t:starch degradation V", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-5821:t:dalcochinin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7056:t:daphnin interconversion", "PWY-7256:t:cyanidin diglucoside biosynthesis (acyl-glucose dependent)"], "type": "Domain"}, "IPR041220": {"description": "Large polyvalent protein associated domain 24", "go_ids": [], "go_terms": [], "name": "LPD24", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041221": {"description": "Anaphase-promoting complex subunit 1, C-terminal", "go_ids": [], "go_terms": [], "name": "APC1_C", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-HSA-2467813", "R-MMU-2467813", "R-MMU-174154", "R-MMU-179409", "R-MMU-69017", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-DDI-176409", "R-DDI-2559582", "R-DDI-2467813", "R-DDI-176412", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-68867", "R-MMU-176409", "R-DDI-174084", "R-HSA-176409", "R-HSA-9687136", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-MMU-141430", "R-DDI-174184", "R-HSA-69017", "R-DDI-141430", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-DDI-174178", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Domain"}, "IPR041222": {"description": "Primosomal protein N', 3' DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "PriA_3primeBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041223": {"description": "ApeA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ApeA_NTD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041224": {"description": "Beta-porphyranase A, C-terminal", "go_ids": [], "go_terms": [], "name": "BPA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041225": {"description": "Cas9, topo homolgy domain", "go_ids": [], "go_terms": [], "name": "Cas9_Topo", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041226": {"description": "Nitrososphaera output domain 2", "go_ids": [], "go_terms": [], "name": "NitrOD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041227": {"description": "Mu-like prophage FluMu N-terminal domain", "go_ids": [], "go_terms": [], "name": "FluMu_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041228": {"description": "Dynein heavy chain, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Dhc_C", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR041229": {"description": "Apea-like HEPN", "go_ids": [], "go_terms": [], "name": "HEPN_Apea", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041230": {"description": "FbpC, C-terminal regulatory nucleotide binding domain", "go_ids": [], "go_terms": [], "name": "FbpC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041231": {"description": "FlgA, N-terminal", "go_ids": [], "go_terms": [], "name": "FlgA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041232": {"description": "Nucleoplasmin-like domain", "go_ids": [], "go_terms": [], "name": "NPL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041233": {"description": "Alpha galactosidase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Melibiase_C", "pathway_ids": ["PWY-6527"], "pathways": ["PWY-6527:t:stachyose degradation"], "type": "Domain"}, "IPR041234": {"description": "RavJ-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RavJ-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041235": {"description": "Exportin-1, repeat 2", "go_ids": [], "go_terms": [], "name": "Exp1_repeat_2", "pathway_ids": ["R-MMU-9856649", "R-DME-69273", "R-DME-9634638", "R-HSA-2467813", "R-HSA-3769402", "R-SPO-5687128", "R-DME-9707616", "R-RNO-2500257", "R-MMU-2467813", "R-SCE-9856649", "R-HSA-69273", "R-RNO-450520", "R-RNO-5687128", "R-MMU-68877", "R-RNO-9634638", "R-HSA-168333", "R-HSA-9828806", "R-HSA-68877", "R-MMU-9707616", "R-HSA-165054", "R-RNO-9707616", "R-RNO-141444", "R-MMU-9648025", "R-MMU-2500257", "R-MMU-3769402", "R-RNO-68877", "R-HSA-2500257", "R-DDI-5687128", "R-MMU-141444", "R-RNO-9856649", "R-HSA-9918432", "R-DME-9856649", "R-HSA-141444", "R-HSA-450520", "R-HSA-9707616", "R-MMU-450520", "R-HSA-9648025", "R-DME-450520", "R-HSA-9634638", "R-RNO-5663220", "R-RNO-69273", "R-DME-3769402", "R-HSA-5687128", "R-HSA-9856649", "R-HSA-5663220", "R-MMU-9634638", "R-MMU-5687128", "R-SCE-5687128", "R-MMU-69273", "R-HSA-2173788", "R-RNO-9648025", "R-RNO-2467813", "R-RNO-3769402", "R-MMU-5663220", "R-HSA-9768919"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-DME-9707616:r:Heme signaling", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-9707616:r:Heme signaling", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-9707616:r:Heme signaling", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9707616:r:Heme signaling", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Repeat"}, "IPR041236": {"description": "Primosomal protein N, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PriA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041237": {"description": "Adhesin BspA, variable domain", "go_ids": [], "go_terms": [], "name": "BspA_v", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041238": {"description": "Rap1a immunity protein", "go_ids": [], "go_terms": [], "name": "Rap1a", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041239": {"description": "Domain of unknown function DUF5605", "go_ids": [], "go_terms": [], "name": "DUF5605", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041240": {"description": "Protein of unknown function DUF5541", "go_ids": [], "go_terms": [], "name": "DUF5541", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041241": {"description": "Thymine dioxygenase JBP1, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "DB_JBP1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041242": {"description": "Putative HNHc nuclease", "go_ids": [], "go_terms": [], "name": "HNHc_6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041243": {"description": "STI1/HOP, DP domain", "go_ids": [], "go_terms": [], "name": "STI1/HOP_DP", "pathway_ids": ["R-SCE-3371497", "R-SPO-3371497", "R-RNO-3371453", "R-HSA-3371453", "R-BTA-9696273", "R-SPO-9696273", "R-BTA-3371497", "R-RNO-3371497", "R-HSA-3371497", "R-RNO-9696273", "R-MMU-9696273", "R-SCE-9696273", "R-PFA-3371497", "R-MMU-3371497", "R-HSA-9696273", "R-MMU-3371453"], "pathways": ["R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-9696273:r:RND1 GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9696273:r:RND1 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-SCE-9696273:r:RND1 GTPase cycle", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR041244": {"description": "Large ribosomal subunit protein bL27m, C-terminal", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL27m_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041245": {"description": "CARMIL, pleckstrin homology domain", "go_ids": [], "go_terms": [], "name": "CARMIL_PH", "pathway_ids": ["R-HSA-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR041246": {"description": "Bacterial alpha-2-macroglobulin MG10 domain", "go_ids": [], "go_terms": [], "name": "Bact_MG10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041247": {"description": "Rad52 family", "go_ids": [], "go_terms": [], "name": "Rad52_fam", "pathway_ids": ["R-SCE-3108214", "R-SCE-5685938", "R-MMU-5685938", "R-GGA-5685938", "R-SPO-3108214", "R-GGA-3108214", "R-HSA-3108214", "R-SPO-5685938", "R-MMU-5685939", "R-GGA-5685939", "R-MMU-3108214", "R-HSA-5685939", "R-HSA-5685938"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-GGA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Family"}, "IPR041248": {"description": "YDG domain", "go_ids": [], "go_terms": [], "name": "YDG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041249": {"description": "DZIP3-like HEPN domain", "go_ids": [], "go_terms": [], "name": "HEPN_DZIP3", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR041250": {"description": "ParA helix turn helix domain", "go_ids": [], "go_terms": [], "name": "HTH_54", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041251": {"description": "SAGA-associated factor 73, zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_13", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041252": {"description": "RL domain", "go_ids": [], "go_terms": [], "name": "RL", "pathway_ids": ["R-HSA-9937008"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification"], "type": "Domain"}, "IPR041253": {"description": "Carbohydrate binding module 77", "go_ids": [], "go_terms": [], "name": "CBM77", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041254": {"description": "Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1", "go_ids": [], "go_terms": [], "name": "PCSK9_C1", "pathway_ids": ["PWY-7884", "R-RNO-381426", "R-HSA-381426", "R-HSA-8866427", "R-RNO-8957275", "R-MMU-8866427", "R-MMU-381426", "R-MMU-8964038", "R-HSA-8957275", "R-RNO-8964038", "R-RNO-8866427", "R-MMU-8957275", "R-HSA-8964038"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8964038:r:LDL clearance", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964038:r:LDL clearance"], "type": "Domain"}, "IPR041255": {"description": "LpxI N-terminal domain", "go_ids": [], "go_terms": [], "name": "LpxI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041256": {"description": "CDI immunity protein", "go_ids": [], "go_terms": [], "name": "CdiI_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041257": {"description": "Adenomatous polyposis coli (APC) repeat", "go_ids": [], "go_terms": [], "name": "APC_rep", "pathway_ids": ["R-HSA-5358751", "R-HSA-5358752", "R-HSA-5358749", "R-MMU-3769402", "R-MMU-196299", "R-HSA-3769402", "R-RNO-4641262", "R-HSA-5689896", "R-HSA-5467348", "R-MMU-5689896", "R-HSA-196299", "R-HSA-5467340", "R-RNO-111465", "R-HSA-5358747", "R-RNO-196299", "R-HSA-5339716", "R-HSA-5467337", "R-MMU-4641262", "R-HSA-4641262", "R-HSA-111465", "R-MMU-111465", "R-RNO-3769402", "R-RNO-5689896", "R-HSA-5467333", "R-RNO-195253", "R-MMU-195253", "R-HSA-195253"], "pathways": ["R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-5467333:r:APC truncation mutants are not K63 polyubiquitinated", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Repeat"}, "IPR041258": {"description": "Large polyvalent protein-associated domain 18", "go_ids": [], "go_terms": [], "name": "LPD18", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041260": {"description": "Sld7 C-terminal domain", "go_ids": [], "go_terms": [], "name": "Sld7_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041261": {"description": "ATP-grasp domain, R2K clade family 2", "go_ids": [], "go_terms": [], "name": "R2K_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041262": {"description": "Spore germination GerD, central core domain", "go_ids": [], "go_terms": [], "name": "GerD_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041263": {"description": "Gasdermin, PUB domain", "go_ids": [], "go_terms": [], "name": "Gasdermin_PUB", "pathway_ids": ["R-HSA-6798695", "R-MMU-9960525", "R-HSA-9960525", "R-HSA-5620971", "R-HSA-9660826", "R-MMU-5686938", "R-HSA-9960519", "R-HSA-9710421", "R-HSA-111457", "R-HSA-448706", "R-MMU-448706", "R-MMU-9960519", "R-MMU-111457", "R-MMU-6798695", "R-MMU-5620971", "R-HSA-5686938"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-9960525:r:CASP5-mediated substrate cleavage", "R-HSA-5620971:r:Pyroptosis", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9960519:r:CASP4-mediated substrate cleavage", "R-HSA-9710421:r:Defective pyroptosis", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-448706:r:Interleukin-1 processing", "R-MMU-448706:r:Interleukin-1 processing", "R-MMU-9960519:r:CASP4-mediated substrate cleavage", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5620971:r:Pyroptosis", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand"], "type": "Domain"}, "IPR041264": {"description": "SidC, N-terminal", "go_ids": [], "go_terms": [], "name": "SidC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041265": {"description": "Propionyl-coenzyme A carboxylase, BT domain", "go_ids": [], "go_terms": [], "name": "PCC_BT", "pathway_ids": ["PWY-5743", "PWY-5789", "PWYG-321", "PWY-7384", "PWY-6728", "R-CEL-196780", "R-RNO-196780", "R-CEL-71032", "R-HSA-71032", "R-HSA-196780", "R-RNO-71032", "R-MMU-71032", "R-HSA-3371599", "R-MMU-196780"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWYG-321:t:mycolate biosynthesis", "PWY-7384:t:anaerobic energy metabolism (invertebrates, mitochondrial)", "PWY-6728:t:methylaspartate cycle", "R-CEL-196780:r:Biotin transport and metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-HSA-196780:r:Biotin transport and metabolism", "R-RNO-71032:r:Propionyl-CoA catabolism", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-196780:r:Biotin transport and metabolism"], "type": "Domain"}, "IPR041266": {"description": "EDS1, EP domain", "go_ids": [], "go_terms": [], "name": "EDS1_EP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041267": {"description": "NACHT, LRR and PYD domains-containing protein, helical domain HD2", "go_ids": [], "go_terms": [], "name": "NLRP_HD2", "pathway_ids": ["R-HSA-5689901", "R-HSA-1606341", "R-HSA-9020702", "R-HSA-9705671", "R-HSA-168638", "R-HSA-168928", "R-MMU-450302", "R-MMU-844455", "R-HSA-5689896", "R-MMU-5689901", "R-RNO-844455", "R-HSA-936440", "R-RNO-5689901", "R-MMU-5689896", "R-HSA-450321", "R-BTA-450321", "R-HSA-450302", "R-HSA-9707564", "R-MMU-168638", "R-BTA-168638", "R-HSA-844455", "R-BTA-5689901", "R-DRE-5689901", "R-HSA-3270619", "R-MMU-3270619", "R-BTA-5689896", "R-MMU-3134975", "R-HSA-9758274", "R-HSA-9660826", "R-MMU-450321", "R-RNO-844456", "R-MMU-844456", "R-BTA-844456", "R-DRE-844456", "R-BTA-450302", "R-HSA-9692916", "R-HSA-3134975", "R-MMU-9758274", "R-HSA-844456", "R-HSA-445989"], "pathways": ["R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-844455:r:The NLRP1 inflammasome", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689901:r:Metalloprotease DUBs", "R-RNO-844455:r:The NLRP1 inflammasome", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-5689901:r:Metalloprotease DUBs", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-844455:r:The NLRP1 inflammasome", "R-BTA-5689901:r:Metalloprotease DUBs", "R-DRE-5689901:r:Metalloprotease DUBs", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-BTA-844456:r:The NLRP3 inflammasome", "R-DRE-844456:r:The NLRP3 inflammasome", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation"], "type": "Domain"}, "IPR041268": {"description": "CCDC81-like prokaryotic HU domain 2", "go_ids": [], "go_terms": [], "name": "HU-CCDC81_bac_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041269": {"description": "Sulfhydryl oxidase, Trx-like domain", "go_ids": [], "go_terms": [], "name": "QSOX_Trx1", "pathway_ids": ["PWY-7533", "R-RNO-381426", "R-HSA-6798695", "R-HSA-114608", "R-RNO-8957275", "R-MMU-381426", "R-MMU-6798695", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR041270": {"description": "Phage ABA sandwich domain", "go_ids": [], "go_terms": [], "name": "Phage_ABA_S", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041271": {"description": "Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3", "go_ids": [], "go_terms": [], "name": "AGPT-Pplase3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041272": {"description": "N-acetyl-beta-D-glucosaminidase, N-terminal", "go_ids": [], "go_terms": [], "name": "GcnA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041273": {"description": "N-acyltransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NAT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041274": {"description": "Isopullulanase beta-solenoid repeat", "go_ids": [], "go_terms": [], "name": "IPU_b_solenoid", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR041275": {"description": "ESX-1 secretion-associated protein EspB, PE domain", "go_ids": [], "go_terms": [], "name": "EspB_PE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041276": {"description": "Vacuolar ATPase subunit I, N-terminal proximal lobe", "go_ids": [], "go_terms": [], "name": "V_ATPase_prox", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041277": {"description": "MBG domain, Lactobacillales", "go_ids": [], "go_terms": [], "name": "MBG_Lactobacillales", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041278": {"description": "Chitinase W-like, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "ChiW-like_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041279": {"description": "Giardia dicer, N-terminal", "go_ids": [], "go_terms": [], "name": "Dicer_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041280": {"description": "Bacterial Ig domain, transpeptidase-associated", "go_ids": [], "go_terms": [], "name": "Big_10", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis"], "type": "Domain"}, "IPR041281": {"description": "CD180, leucine-rich repeat", "go_ids": [], "go_terms": [], "name": "LRR_11", "pathway_ids": ["R-MMU-166016", "R-HSA-166016"], "pathways": ["R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade"], "type": "Repeat"}, "IPR041282": {"description": "FYVE-type zinc finger", "go_ids": [], "go_terms": [], "name": "FYVE_2", "pathway_ids": ["R-HSA-114608", "R-MMU-9824585", "R-HSA-264876", "R-RNO-9824585", "R-HSA-8986944", "R-HSA-9824585", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-264876:r:Insulin processing", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR041283": {"description": "Leucine-rich repeat unit", "go_ids": [], "go_terms": [], "name": "LRR_12", "pathway_ids": ["R-MMU-1679131", "R-HSA-168138", "R-MMU-109704", "R-SSC-1679131", "R-HSA-975138", "R-HSA-109704", "R-SSC-168138", "R-SSC-109704", "R-HSA-9679191", "R-CFA-109704", "R-MMU-5686938", "R-CFA-168138", "R-HSA-975155", "R-HSA-1679131", "R-CFA-1679131", "R-MMU-168181", "R-HSA-975110", "R-MMU-168138"], "pathways": ["R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-109704:r:PI3K Cascade", "R-SSC-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-109704:r:PI3K Cascade", "R-SSC-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SSC-109704:r:PI3K Cascade", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-CFA-109704:r:PI3K Cascade", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-CFA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-CFA-1679131:r:Trafficking and processing of endosomal TLR", "R-MMU-168181:r:Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade"], "type": "Repeat"}, "IPR041284": {"description": "Fungal defensin Copsin", "go_ids": [], "go_terms": [], "name": "Copsin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041285": {"description": "MID domain of medPIWI", "go_ids": [], "go_terms": [], "name": "MID_MedPIWI", "pathway_ids": ["R-HSA-1989781", "R-DME-9841922", "R-HSA-381340", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "type": "Domain"}, "IPR041286": {"description": "MBG domain, YGX type", "go_ids": [], "go_terms": [], "name": "MBG_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041287": {"description": "Protein of unknown function DUF5548", "go_ids": [], "go_terms": [], "name": "DUF5548", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041289": {"description": "Ribosome hibernation factor Balon, middle domain", "go_ids": [], "go_terms": [], "name": "Balon_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041290": {"description": "Tle cognate immunity protein 4, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tli4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041291": {"description": "Histone methyltransferase, Tudor domain 1", "go_ids": [], "go_terms": [], "name": "TUDOR_5", "pathway_ids": ["R-MMU-3214841", "R-MMU-9843940", "R-DRE-9843940", "R-HSA-3214841", "R-DRE-3214841", "R-HSA-9843970", "R-DME-3214841", "R-DRE-9843970", "R-DME-9843940", "R-HSA-9843940"], "pathways": ["R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DME-3214841:r:PKMTs methylate histone lysines", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DME-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins"], "type": "Domain"}, "IPR041292": {"description": "Histone methyltransferase, Tudor domain 2", "go_ids": [], "go_terms": [], "name": "Tudor_4", "pathway_ids": ["R-MMU-3214841", "R-MMU-9843940", "R-DRE-9843940", "R-HSA-3214841", "R-DRE-3214841", "R-HSA-9843970", "R-DME-3214841", "R-DRE-9843970", "R-DME-9843940", "R-HSA-9843940"], "pathways": ["R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DME-3214841:r:PKMTs methylate histone lysines", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DME-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins"], "type": "Domain"}, "IPR041293": {"description": "Serine-tRNA ligase type 2, tRNA-binding domain", "go_ids": [], "go_terms": [], "name": "SerS_tRNA-bd", "pathway_ids": ["PWY-6281"], "pathways": ["PWY-6281:t:L-selenocysteine biosynthesis II (archaea and eukaryotes)"], "type": "Domain"}, "IPR041294": {"description": "Ankyrin ubiquitin-binding domain", "go_ids": [], "go_terms": [], "name": "AnkUBD", "pathway_ids": ["R-DME-5689896", "R-DME-195253", "R-BTA-5689896", "R-DRE-195253", "R-BTA-195253", "R-HSA-5689896", "R-XTR-195253", "R-DRE-5689896", "R-MMU-5689896", "R-XTR-5689896", "R-MMU-195253", "R-HSA-195253"], "pathways": ["R-DME-5689896:r:Ovarian tumor domain proteases", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-XTR-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Domain"}, "IPR041295": {"description": "MapZ, extracellular domain 1", "go_ids": [], "go_terms": [], "name": "MapZ_EC1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041296": {"description": "ISP3, C-terminal", "go_ids": [], "go_terms": [], "name": "ISP3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041297": {"description": "DNA repair protein Crb2, Tudor domain", "go_ids": [], "go_terms": [], "name": "Crb2_Tudor", "pathway_ids": ["R-MMU-3214847", "R-SPO-9770562", "R-HSA-9772755", "R-HSA-6804757", "R-MMU-6804757", "R-MMU-9772755", "R-HSA-3214847", "R-HSA-69541", "R-MMU-6804759", "R-SPO-72163", "R-MMU-69541", "R-HSA-6804759"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-69541:r:Stabilization of p53", "R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-69541:r:Stabilization of p53", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors"], "type": "Domain"}, "IPR041298": {"description": "DNA polymerase eta, ubiquitin-binding zinc finger", "go_ids": [], "go_terms": [], "name": "UBZ3", "pathway_ids": ["R-HSA-5685942", "R-SPO-110320", "R-SPO-5656169", "R-DME-110320", "R-MMU-110320", "R-MMU-5656169", "R-MMU-5685942", "R-HSA-5656169", "R-HSA-110320"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-DME-110320:r:Translesion Synthesis by POLH", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-110320:r:Translesion Synthesis by POLH"], "type": "Domain"}, "IPR041299": {"description": "Chromatin remodeling factor Mit1, C-terminal Zn finger 1", "go_ids": [], "go_terms": [], "name": "Znf-CCCH_7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041300": {"description": "CxC7-like cysteine cluster associated with KDZ transposases", "go_ids": [], "go_terms": [], "name": "CxC7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041301": {"description": "Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 3", "go_ids": [], "go_terms": [], "name": "PBECR3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041302": {"description": "Ribonuclease inhibitor, leucine rich repeat cap", "go_ids": [], "go_terms": [], "name": "LRR_RI_cap", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR041303": {"description": "Phage spike trimer 2", "go_ids": [], "go_terms": [], "name": "Phage_spike_2", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR041304": {"description": "AbiTii", "go_ids": [], "go_terms": [], "name": "AbiTii", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041305": {"description": "Interleukin-4 inducing immunoglobulin-binding domain", "go_ids": [], "go_terms": [], "name": "IL4_i_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041306": {"description": "NSD, Cys-His rich domain", "go_ids": [], "go_terms": [], "name": "C5HCH", "pathway_ids": ["R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-MMU-3214841", "R-HSA-3214841", "R-HSA-69473", "R-HSA-5693565", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR041307": {"description": "Polysaccharide biosynthesis enzyme WcbI", "go_ids": [], "go_terms": [], "name": "WcbI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041308": {"description": "Xer recombinase, N-terminal", "go_ids": [], "go_terms": [], "name": "Xer_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041309": {"description": "TANK-binding kinase 1, coiled-coil domain 1", "go_ids": [], "go_terms": [], "name": "TBK1_CC1", "pathway_ids": ["R-HSA-1606341", "R-HSA-4755510", "R-HSA-9705671", "R-HSA-9920588", "R-HSA-168928", "R-HSA-9828211", "R-HSA-9824878", "R-HSA-936440", "R-MMU-5205685", "R-HSA-936964", "R-HSA-918233", "R-MMU-9008059", "R-HSA-5357905", "R-HSA-5205685", "R-MMU-9824878", "R-MMU-936964", "R-HSA-3270619", "R-MMU-5357786", "R-MMU-168928", "R-MMU-3270619", "R-HSA-9013973", "R-MMU-3134975", "R-HSA-9679191", "R-HSA-5357786", "R-HSA-9008059", "R-MMU-3249367", "R-HSA-933541", "R-HSA-9692916", "R-MMU-5357905", "R-HSA-3249367", "R-HSA-3134975", "R-MMU-936440", "R-HSA-9860927", "R-MMU-4755510", "R-MMU-9860927"], "pathways": ["R-HSA-1606341:r:IRF3 mediated activation of type 1 IFN", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-9008059:r:Interleukin-37 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-4755510:r:SUMOylation of immune response proteins", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "type": "Domain"}, "IPR041310": {"description": "TNF receptor-associated factor 6, zinc finger 2", "go_ids": [], "go_terms": [], "name": "TRAF6_Z2", "pathway_ids": ["PWY-7511", "R-HSA-9020702", "R-RNO-9758274", "R-SSC-937039", "R-HSA-168638", "R-BTA-5689880", "R-MMU-6811558", "R-HSA-5689880", "R-SSC-209543", "R-SSC-193692", "R-MMU-9020702", "R-MMU-937072", "R-XTR-202424", "R-BTA-975144", "R-RNO-193692", "R-MMU-5689896", "R-XTR-209543", "R-MMU-937042", "R-BTA-450321", "R-MMU-5689880", "R-BTA-166058", "R-RNO-6811558", "R-HSA-168927", "R-BTA-6811558", "R-HSA-450302", "R-XTR-450321", "R-HSA-937041", "R-RNO-937042", "R-SSC-975144", "R-SSC-450321", "R-MMU-975144", "R-RNO-975144", "R-HSA-205043", "R-RNO-975163", "R-HSA-9758274", "R-SSC-450302", "R-MMU-450321", "R-HSA-975163", "R-RNO-209543", "R-RNO-5689880", "R-MMU-975138", "R-RNO-975138", "R-XTR-937042", "R-BTA-205043", "R-SSC-5689896", "R-HSA-9705671", "R-MMU-450302", "R-HSA-937042", "R-RNO-937072", "R-HSA-933542", "R-RNO-1257604", "R-MMU-9645460", "R-BTA-975871", "R-RNO-450321", "R-MMU-193692", "R-BTA-2871837", "R-BTA-209543", "R-RNO-9645460", "R-BTA-445989", "R-SSC-9020702", "R-MMU-205043", "R-SSC-975163", "R-BTA-209560", "R-BTA-975138", "R-MMU-202424", "R-XTR-166058", "R-RNO-937041", "R-XTR-450302", "R-HSA-975871", "R-RNO-2871837", "R-MMU-209560", "R-SSC-5607764", "R-MMU-1257604", "R-XTR-9645460", "R-SSC-937041", "R-SSC-202424", "R-BTA-9645460", "R-HSA-933541", "R-SSC-9758274", "R-BTA-1257604", "R-MMU-937041", "R-HSA-937039", "R-XTR-975871", "R-MMU-975871", "R-SSC-975138", "R-RNO-9020702", "R-MMU-5607764", "R-XTR-209560", "R-HSA-5689896", "R-XTR-5607764", "R-BTA-202424", "R-SSC-6811558", "R-HSA-450321", "R-MMU-445989", "R-BTA-9758274", "R-SSC-937042", "R-BTA-937041", "R-RNO-202424", "R-RNO-205043", "R-MMU-975163", "R-SSC-445989", "R-XTR-5689880", "R-HSA-166058", "R-BTA-937042", "R-HSA-209560", "R-MMU-209543", "R-HSA-975144", "R-SSC-9645460", "R-RNO-209560", "R-SSC-166058", "R-HSA-6811558", "R-BTA-193692", "R-XTR-975138", "R-MMU-2871837", "R-RNO-450302", "R-RNO-445989", "R-RNO-168638", "R-HSA-975110", "R-RNO-5689896", "R-HSA-1257604", "R-BTA-937039", "R-HSA-193692", "R-XTR-975163", "R-HSA-445989", "R-SSC-1257604", "R-SSC-209560", "R-SSC-975871", "R-HSA-975138", "R-HSA-209543", "R-BTA-937072", "R-HSA-2871837", "R-MMU-937039", "R-SSC-5689880", "R-SSC-937072", "R-MMU-168638", "R-BTA-168638", "R-HSA-937072", "R-HSA-5607764", "R-XTR-9758274", "R-RNO-937039", "R-XTR-2871837", "R-BTA-5689896", "R-MMU-166058", "R-RNO-166058", "R-HSA-9645460", "R-RNO-975871", "R-SSC-2871837", "R-HSA-975155", "R-RNO-5607764", "R-BTA-450302", "R-BTA-9020702", "R-HSA-9692916", "R-HSA-9014325", "R-BTA-5607764", "R-MMU-9758274", "R-HSA-202424", "R-XTR-5689896", "R-BTA-975163"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-SSC-937039:r:IRAK1 recruits IKK complex", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SSC-209543:r:p75NTR recruits signalling complexes", "R-SSC-193692:r:Regulated proteolysis of p75NTR", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-XTR-202424:r:Downstream TCR signaling", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-XTR-209543:r:p75NTR recruits signalling complexes", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-XTR-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SSC-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-RNO-5689880:r:Ub-specific processing 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"R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-XTR-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-SSC-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-SSC-5689880:r:Ub-specific processing proteases", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-9020702:r:Interleukin-1 signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Domain"}, "IPR041311": {"description": "Large polyvalent protein associated domain 29", "go_ids": [], "go_terms": [], "name": "LPD29", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041312": {"description": "CHIP, N-terminal tetratricopeptide repeat domain", "go_ids": [], "go_terms": [], "name": "CHIP_TPR_N", "pathway_ids": ["PWY-7511", "R-MMU-8863795", "R-RNO-8948751", "R-HSA-5675482", "R-MMU-5675482", "R-RNO-5357905", "R-RNO-2173788", "R-HSA-983168", "R-MMU-8948751", "R-RNO-8863795", "R-HSA-8939902", "R-HSA-5213460", "R-HSA-5357905", "R-HSA-8863795", "R-MMU-8939902", "R-MMU-5357905", "R-MMU-983168", "R-HSA-8948751", "R-RNO-5675482", "R-MMU-2173788", "R-RNO-983168", "R-HSA-2173788"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling"], "type": "Domain"}, "IPR041313": {"description": "Domain of unknown function DUF5642", "go_ids": [], "go_terms": [], "name": "DUF5642", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041315": {"description": "PlcR, tetratricopeptide repeat", "go_ids": [], "go_terms": [], "name": "PlcR_TPR", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR041316": {"description": "ISP1 C-terminal", "go_ids": [], "go_terms": [], "name": "ISP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041317": {"description": "RET, cadherin-like domain 4", "go_ids": [], "go_terms": [], "name": "RET_CLD4", "pathway_ids": ["R-HSA-9830674", "R-HSA-8853659", "R-RNO-8853659", "R-HSA-9830364", "R-MMU-8853659", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-9768919", "R-HSA-5673001"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8853659:r:RET signaling", "R-RNO-8853659:r:RET signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-MMU-8853659:r:RET signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Domain"}, "IPR041318": {"description": "pEK499_p136 HEPN domain", "go_ids": [], "go_terms": [], "name": "pEK499_p136", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041319": {"description": "Protein of unknown function DUF5543", "go_ids": [], "go_terms": [], "name": "DUF5543", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041320": {"description": "CxC1-like cysteine cluster associated with KDZ transposases", "go_ids": [], "go_terms": [], "name": "CxC1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041321": {"description": "Lpg0393, helical bundle domain", "go_ids": [], "go_terms": [], "name": "Lpg0393_HBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041322": {"description": "Synaptonemal complex protein 2, armadillo-repeat-like domain", "go_ids": [], "go_terms": [], "name": "SYCP2_ARLD", "pathway_ids": ["R-HSA-1221632"], "pathways": ["R-HSA-1221632:r:Meiotic synapsis"], "type": "Domain"}, "IPR041323": {"description": "HEPN-like integron domain", "go_ids": [], "go_terms": [], "name": "HEPN-like_int", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041324": {"description": "Antigen I/II, N-terminal", "go_ids": ["GO:0005618"], "go_terms": ["GO:0005618:cell wall:C"], "name": "AgI/II_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041325": {"description": "Protein glutaminase", "go_ids": [], "go_terms": [], "name": "Gln_deamidase_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041326": {"description": "Tk-SP N-propeptide domain", "go_ids": [], "go_terms": [], "name": "Tk-SP_N-pro", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041327": {"description": "ATP nucleosidase Cap17-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Cap17-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041328": {"description": "ResE, histidine kinase sensor domain", "go_ids": [], "go_terms": [], "name": "HisK_sensor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041329": {"description": "YubB, ferredoxin-like domain", "go_ids": [], "go_terms": [], "name": "YubB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041330": {"description": "KN17, SH3-like domain", "go_ids": [], "go_terms": [], "name": "KN17_SH3", "pathway_ids": ["R-HSA-8876725", "R-MMU-8876725"], "pathways": ["R-HSA-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation"], "type": "Domain"}, "IPR041331": {"description": "Bacterial alpha amylase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Bac_A_amyl_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041332": {"description": "Pan3, C-terminal knob domain", "go_ids": [], "go_terms": [], "name": "Pan3_CK", "pathway_ids": ["R-MMU-429947", "R-DME-429947", "R-SPO-429947", "R-HSA-429947", "R-SCE-429947"], "pathways": ["R-MMU-429947:r:Deadenylation of mRNA", "R-DME-429947:r:Deadenylation of mRNA", "R-SPO-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-SCE-429947:r:Deadenylation of mRNA"], "type": "Domain"}, "IPR041333": {"description": "Peptidase M60, C-terminal", "go_ids": [], "go_terms": [], "name": "M60_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041334": {"description": "SAV2148-like HEPN domain", "go_ids": [], "go_terms": [], "name": "HEPN_SAV2148", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041335": {"description": "DNA mismatch repair protein HSM3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HSM3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041336": {"description": "DNA mitochondrial polymerase, exonuclease domain", "go_ids": [], "go_terms": [], "name": "DNApol_Exo", "pathway_ids": ["R-DME-9913635", "R-MMU-9913635", "R-RNO-9913635", "R-HSA-9913635"], "pathways": ["R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-RNO-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Domain"}, "IPR041337": {"description": "Heterogeneous nuclear ribonucleoprotein Q acidic domain", "go_ids": [], "go_terms": [], "name": "hnRNP_Q_AcD", "pathway_ids": ["R-HSA-9770562", "R-HSA-9918481", "R-HSA-72163", "R-HSA-72203"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Domain"}, "IPR041338": {"description": "OSBS, enolase-like N-terminal domain", "go_ids": [], "go_terms": [], "name": "OSBS_N", "pathway_ids": ["PWY-5837"], "pathways": ["PWY-5837:t:2-carboxy-1,4-naphthoquinol biosynthesis"], "type": "Domain"}, "IPR041339": {"description": "Cell-surface Ig-like, bacterial", "go_ids": [], "go_terms": [], "name": "Ig-like_bac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041340": {"description": "PIK3AP1, Toll/interleukin-1 receptor domain", "go_ids": [], "go_terms": [], "name": "PIK3AP1_TIR", "pathway_ids": ["R-GGA-983695", "R-HSA-983695", "R-MMU-6811558", "R-GGA-6811558", "R-HSA-2219530", "R-HSA-1257604", "R-MMU-1257604", "R-MMU-983695", "R-GGA-1257604", "R-HSA-6811558"], "pathways": ["R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", 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[], "go_terms": [], "name": "PRC2_HTH_1", "pathway_ids": ["R-DME-9909649", "R-MMU-8953750", "R-HSA-5617472", "R-MMU-3214841", "R-HSA-2559580", "R-DME-212300", "R-DRE-2559580", "R-XTR-212300", "R-XTR-9764725", "R-DRE-8953750", "R-HSA-9764725", "R-MMU-212300", "R-HSA-8953750", "R-HSA-9609690", "R-MMU-9764725", "R-MMU-2559580", "R-MMU-8943724", "R-HSA-9710421", "R-DME-2559580", "R-XTR-8953750", "R-HSA-212300", "R-HSA-9909649", "R-XTR-9909649", "R-DRE-3214841", "R-HSA-3214841", "R-MMU-9909649", "R-BTA-212300", "R-HSA-8943724", "R-DME-9764725", "R-DME-8953750", "R-XTR-2559580", "R-DRE-212300", "R-DRE-9909649", "R-DME-8943724", "R-DRE-9764725"], "pathways": ["R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9710421:r:Defective pyroptosis", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription"], "type": "Domain"}, "IPR041344": {"description": "30K viral movement protein, core domain", "go_ids": [], "go_terms": [], "name": "30K_MP_core", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041345": {"description": "Reovirus sigma C capsid protein triple beta spiral", "go_ids": [], "go_terms": [], "name": "Reo_sigmaC_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041346": {"description": "DR2241, 4Fe-4S iron-sulfur cluster binding domain", "go_ids": [], "go_terms": [], "name": "DR2241_Fer4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041347": {"description": "MftR, C-terminal", "go_ids": [], "go_terms": [], "name": "MftR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041348": {"description": "VEGFR-2, transmembrane domain", "go_ids": [], "go_terms": [], "name": "VEGFR-2_TMD", "pathway_ids": ["R-HSA-216083", "R-DRE-194306", "R-DRE-5218921", "R-MMU-4420097", "R-RNO-195399", "R-HSA-9673768", "R-HSA-194306", "R-DRE-195399", "R-HSA-4420097", "R-MMU-195399", "R-HSA-5218921", "R-RNO-5218921", "R-HSA-9013695", "R-DRE-4420097", "R-HSA-9856530", "R-HSA-195399", "R-MMU-194306", "R-MMU-5218921", "R-RNO-194306", "R-RNO-4420097"], "pathways": ["R-HSA-216083:r:Integrin cell surface interactions", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR041349": {"description": "Proline utilization A proline dehydrogenase N-terminal domain", "go_ids": [], "go_terms": [], "name": "PRODH", "pathway_ids": ["PWY-6922", "PWY-5737", "PWY-6853"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-5737:t:(5R)-carbapenem carboxylate biosynthesis", "PWY-6853:t:ethene biosynthesis II (microbes)"], "type": "Domain"}, "IPR041350": {"description": "Carbon monoxide dehydrogenase subunit alpha ,N-terminal", "go_ids": [], "go_terms": [], "name": "CODH_A_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041351": {"description": "Exo-beta-D-glucosaminidase, Ig-fold domain", "go_ids": [], "go_terms": [], "name": "Ig_GlcNase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041352": {"description": "Major tropism determinant, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Mtd_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041353": {"description": "Flax-rust effector AvrM, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AvrM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041354": {"description": "4'-phosphopantetheinyl transferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "4PPT_N", "pathway_ids": ["PWY-6580", "PWY-6350", "PWY-7817", "PWY-7981", "PWY-7819", "PWY-6804", "PWY-7820", "PWY-8248", "PWY-7816", "PWY-7818", "PWY-7815"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-6350:t:archaetidylinositol biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-6804:t:diacylglycerol biosynthesis (PUFA enrichment in oilseed)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"], "type": "Domain"}, "IPR041355": {"description": "Pre-SET CXC domain", "go_ids": [], "go_terms": [], "name": "Pre-SET_CXC", "pathway_ids": ["R-MMU-8953750", "R-HSA-2559580", "R-DRE-2559580", "R-XTR-9764725", "R-DRE-8953750", "R-MMU-212300", "R-HSA-8953750", "R-DME-2559580", "R-CEL-8943724", "R-HSA-3214841", "R-HSA-8943724", "R-DME-9764725", "R-DME-8953750", "R-DRE-212300", "R-DRE-9909649", "R-DME-9909649", "R-BTA-212300", "R-DRE-9764725", "R-MMU-3214841", "R-DME-212300", "R-XTR-212300", "R-HSA-9764725", "R-HSA-9609690", "R-MMU-9764725", "R-MMU-2559580", "R-MMU-8943724", "R-HSA-9710421", "R-XTR-8953750", "R-HSA-212300", "R-HSA-9909649", "R-XTR-9909649", "R-DRE-3214841", "R-MMU-9909649", "R-XTR-2559580", "R-CEL-8953750", "R-DME-8943724", "R-HSA-5617472"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9710421:r:Defective pyroptosis", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "type": "Domain"}, "IPR041356": {"description": "PGM1 C-terminal domain", "go_ids": [], "go_terms": [], "name": "PGM1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041357": {"description": "LegC3 N-terminal, Legionellaceae", "go_ids": [], "go_terms": [], "name": "LegC3_N_Legionellaceae", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041358": {"description": "Rubisco accumulation factor 1, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "Raf1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041359": {"description": "Metanogen output domain 1", "go_ids": [], "go_terms": [], "name": "MetOD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041360": {"description": "ZAP, helix turn helix N-terminal domain", "go_ids": [], "go_terms": [], "name": "ZAP_HTH", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR041361": {"description": "Nidovirus helicase, RING/Ubox like zinc-binding domain", "go_ids": [], "go_terms": [], "name": "Znf-RING_13", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041362": {"description": "Plexin, TIG domain 2", "go_ids": [], "go_terms": [], "name": "TIG2_plexin", "pathway_ids": ["R-HSA-9013405", "R-HSA-416550", "R-RNO-399956", "R-HSA-399956", "R-HSA-416572", "R-DRE-399954", "R-RNO-416700", "R-MMU-399955", "R-HSA-416482", "R-MMU-399956", "R-MMU-416572", "R-RNO-399954", "R-HSA-9615017", "R-DME-416572", "R-HSA-416700", "R-RNO-399955", "R-HSA-399954", "R-DRE-399956", "R-MMU-416482", "R-MMU-399954", "R-DME-416482", "R-HSA-399955", "R-DME-416700", "R-HSA-9696273", "R-MMU-9696273", "R-MMU-416700", "R-MMU-416550"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-RNO-416700:r:Other semaphorin interactions", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-416482:r:G alpha (12/13) signalling events", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-DME-416700:r:Other semaphorin interactions", "R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration"], "type": "Domain"}, "IPR041363": {"description": "LIM interaction domain", "go_ids": [], "go_terms": [], "name": "LID", "pathway_ids": ["R-HSA-9752946", "R-GGA-8939236", "R-HSA-9733709", "R-HSA-9010553", "R-DME-8939236", "R-DRE-8939236", "R-HSA-8939236", "R-XTR-8939236", "R-MMU-8939236"], "pathways": ["R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DRE-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-XTR-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "type": "Domain"}, "IPR041364": {"description": "Rubredoxin binding domain", "go_ids": [], "go_terms": [], "name": "Rbx-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041365": {"description": "Csp protease B, prodomain", "go_ids": [], "go_terms": [], "name": "CspB_prodomain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041366": {"description": "Pre-PUA domain", "go_ids": [], "go_terms": [], "name": "Pre-PUA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041367": {"description": "E3 ligase, CCCH-type zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-CCCH_4", "pathway_ids": ["R-MMU-9930044", "R-SPO-3371453", "R-HSA-9930044", "R-DRE-8948751", "R-SPO-159236", "R-SPO-159227", "R-MMU-198323", "R-SPO-159231", "R-SPO-4551638", "R-HSA-983168", "R-MMU-8948751", "R-RNO-9930044", "R-DRE-198323", "R-SPO-198323", "R-HSA-198323", "R-DRE-983168", "R-SCE-198323", "R-SCE-8948751", "R-SPO-4570464", "R-MMU-983168", "R-SPO-983168", "R-HSA-8948751", "R-SPO-4085377", "R-SPO-8948751", "R-SCE-983168", "R-DRE-72165"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9930044:r:Nuclear RNA decay", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9930044:r:Nuclear RNA decay", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-198323:r:AKT phosphorylates targets in the cytosol", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-8948751:r:Regulation of PTEN stability and activity", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-72165:r:mRNA Splicing - Minor Pathway"], "type": "Domain"}, "IPR041368": {"description": "Dam-replacing protein, HTH domain", "go_ids": [], "go_terms": [], "name": "DRP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041369": {"description": "TrmO, C-terminal", "go_ids": [], "go_terms": [], "name": "TrmO_C", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR041370": {"description": "Methyltransferase EEF1AKMT1/ZCCHC4", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "Mlase_EEF1AKMT1/ZCCHC4", "pathway_ids": ["R-SCE-8876725", "R-HSA-8876725", "R-DRE-8876725", "R-CEL-8876725", "R-GGA-8876725", "R-DDI-8876725", "R-MMU-8876725", "R-DME-8876725", "PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["R-SCE-8876725:r:Protein methylation", "R-HSA-8876725:r:Protein methylation", "R-DRE-8876725:r:Protein methylation", "R-CEL-8876725:r:Protein methylation", "R-GGA-8876725:r:Protein methylation", "R-DDI-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation", "R-DME-8876725:r:Protein methylation", "PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR041371": {"description": "Glycosyl hydrolase family 92 N-terminal domain", "go_ids": [], "go_terms": [], "name": "GH92_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041372": {"description": "Cas3, C-terminal", "go_ids": [], "go_terms": [], "name": "Cas3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041373": {"description": "Reverse transcriptase, RNase H-like domain", "go_ids": [], "go_terms": [], "name": "RT_RNaseH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041374": {"description": "Bacterial archaeo-eukaryotic release factor family 12", "go_ids": [], "go_terms": [], "name": "BaeRF_family12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041375": {"description": "VapC45, PIN like domain", "go_ids": [], "go_terms": [], "name": "VapC45_PIN-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041376": {"description": "Integron Cassette Protein Hfx_Cass5", "go_ids": [], "go_terms": [], "name": "Hfx_Cass5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041377": {"description": "Viral coat protein P2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "P2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041378": {"description": "SbsC C-terminal domain", "go_ids": [], "go_terms": [], "name": "S-layer_SbsC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041379": {"description": "Collagenase ColG-like, catalytic helper subdomain", "go_ids": [], "go_terms": [], "name": "ColG_subdomain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041380": {"description": "Eis-like, acetyltransferase domain", "go_ids": [], "go_terms": [], "name": "Acetyltransf_17", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-9636569"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-9636569:r:Suppression of autophagy"], "type": "Domain"}, "IPR041381": {"description": "JAK1-3/TYK2, pleckstrin homology-like domain", "go_ids": [], "go_terms": [], "name": "JAK1-3/TYK2_PHL_dom", "pathway_ids": ["R-SSC-5673000", "R-RNO-6785807", "R-HSA-9020958", "R-HSA-6802952", "R-MMU-1266695", "R-HSA-9006335", "R-MMU-9674555", "R-RNO-9020558", "R-RNO-9020591", "R-SSC-912526", "R-SSC-69231", "R-HSA-9732724", "R-HSA-69231", "R-HSA-9027284", "R-RNO-512988", "R-RNO-8854691", "R-RNO-877312", "R-SSC-9020933", "R-MMU-9020958", "R-MMU-201556", "R-HSA-5673000", "R-MMU-9732724", "R-RNO-983231", "R-SSC-112411", "R-SSC-982772", "R-HSA-512988", "R-SSC-9705462", "R-SSC-1170546", "R-MMU-909733", "R-HSA-6802955", "R-HSA-2586552", "R-SSC-9674555", "R-HSA-9027283", "R-HSA-8984722", "R-MMU-5673001", "R-HSA-9931295", "R-RNO-5673000", "R-DRE-112411", "R-HSA-1170546", "R-RNO-9732724", "R-HSA-983231", "R-MMU-5673000", "R-RNO-9705462", "R-DRE-909733", "R-DRE-912694", "R-HSA-8983432", "R-SSC-9027284", "R-RNO-9020958", "R-MMU-912526", "R-DRE-6785807", "R-RNO-9006335", "R-HSA-909733", "R-DRE-8983432", "R-SSC-1433557", "R-HSA-8985947", "R-MMU-6785807", "R-HSA-9656223", "R-HSA-9833109", "R-HSA-9705671", "R-HSA-1059683", "R-DRE-877312", "R-MMU-9020956", "R-HSA-6788467", "R-SSC-8854691", "R-RNO-9027284", "R-MMU-9020591", "R-HSA-877312", "R-MMU-512988", "R-RNO-6788467", "R-HSA-9027276", "R-MMU-877312", "R-HSA-9020558", "R-MMU-9027284", "R-RNO-1170546", "R-SSC-1059683", "R-SSC-9006335", "R-MMU-8983432", "R-HSA-110056", "R-RNO-69231", "R-HSA-912526", "R-HSA-877300", "R-SSC-983231", "R-HSA-201556", "R-HSA-9027277", "R-HSA-9725370", "R-HSA-9020956", "R-MMU-8985947", "R-RNO-877300", "R-DRE-9732724", "R-SSC-9020591", "R-DRE-6783783", "R-DRE-1266695", "R-HSA-112411", "R-MMU-9020933", "R-SSC-6785807", "R-SSC-9732724", "R-RNO-9020956", "R-HSA-9670439", "R-RNO-9027276", "R-RNO-8983432", "R-RNO-912526", "R-HSA-9649948", "R-MMU-9020558", "R-DRE-877300", "R-SSC-877300", "R-RNO-5673001", "R-HSA-6783783", "R-HSA-1266695", "R-RNO-201556", "R-MMU-1433557", "R-RNO-9020933", "R-SSC-8984722", "R-MMU-982772", "R-RNO-8984722", "R-HSA-9020933", "R-DRE-8854691", "R-HSA-6785807", "R-HSA-8854691", "R-SSC-512988", "R-MMU-9705462", "R-HSA-5673001", "R-HSA-982772", "R-RNO-1433557", "R-MMU-9027276", "R-HSA-9674555", "R-DRE-6788467", "R-MMU-69231", "R-HSA-449836", "R-RNO-9674555", "R-MMU-112411", "R-RNO-1059683", "R-DRE-9705462", "R-HSA-1169408", "R-MMU-983231", "R-DRE-110056", "R-HSA-3214858", "R-MMU-9931295", "R-SSC-877312", "R-HSA-6802946", "R-RNO-110056", "R-HSA-912694", "R-MMU-6788467", "R-MMU-110056", "R-DRE-1059683", "R-MMU-8854691", "R-RNO-112411", "R-HSA-9020591", "R-MMU-1170546", "R-RNO-1266695", "R-SSC-9027276", "R-SSC-9020956", "R-MMU-8984722", "R-DRE-9020958", "R-RNO-982772", "R-HSA-9679191", "R-HSA-1433557", "R-MMU-1169408", "R-MMU-9006335", "R-MMU-877300", "R-RNO-8985947", "R-SSC-5673001", "R-MMU-1059683", "R-MMU-6783783", "R-HSA-9705462", "R-MMU-912694", "R-SSC-6788467"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-9020591:r:Interleukin-12 signaling", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-HSA-5673000:r:RAF activation", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-SSC-982772:r:Growth hormone receptor signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-2586552:r:Signaling by Leptin", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5673000:r:RAF activation", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5673000:r:RAF activation", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DRE-8983432:r:Interleukin-15 signaling", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DRE-877312:r:Regulation of IFNG signaling", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-201556:r:Signaling by ALK", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-SSC-9020591:r:Interleukin-12 signaling", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DRE-1266695:r:Interleukin-7 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-MMU-9020558:r:Interleukin-2 signaling", "R-DRE-877300:r:Interferon gamma signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-RNO-201556:r:Signaling by ALK", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-877312:r:Regulation of IFNG signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-DRE-1059683:r:Interleukin-6 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-RNO-1266695:r:Interleukin-7 signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-DRE-9020958:r:Interleukin-21 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Domain"}, "IPR041382": {"description": "Bacterial dipeptidyl-peptidase SH3 domain", "go_ids": [], "go_terms": [], "name": "SH3_16", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041383": {"description": "RuvC endonuclease subdomain 3", "go_ids": [], "go_terms": [], "name": "RuvC_III", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041384": {"description": "DNTTIP1, dimerisation domain", "go_ids": [], "go_terms": [], "name": "DNTTIP1_dimer", "pathway_ids": ["R-BTA-9764725", "R-RNO-9764725", "R-HSA-9764725", "R-CEL-9764725", "R-MMU-9764725"], "pathways": ["R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription"], "type": "Domain"}, "IPR041385": {"description": "5'-3' exoribonuclease 1, SH3-like domain", "go_ids": [], "go_terms": [], "name": "SH3_12", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-MMU-450513", "R-HSA-450513", "R-SCE-450513", "R-HSA-9918487", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR041386": {"description": "XIAP-associated factor 1, C-terminal", "go_ids": ["GO:0006915"], "go_terms": ["GO:0006915:apoptotic process:P"], "name": "XAF1_C", "pathway_ids": ["R-HSA-909733"], "pathways": ["R-HSA-909733:r:Interferon alpha/beta signaling"], "type": "Domain"}, "IPR041387": {"description": "FHOD1, N-terminal GTPase-binding domain", "go_ids": [], "go_terms": [], "name": "FHOD1_GBD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041388": {"description": "PNK, FHA domain", "go_ids": [], "go_terms": [], "name": "FHA_2", "pathway_ids": ["R-HSA-5649702", "R-MMU-5649702"], "pathways": ["R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "type": "Domain"}, "IPR041389": {"description": "Importin repeat 6", "go_ids": [], "go_terms": [], "name": "Importin_rep_6", "pathway_ids": ["R-HSA-192905"], "pathways": ["R-HSA-192905:r:vRNP Assembly"], "type": "Repeat"}, "IPR041390": {"description": "Focal adhesion kinase, N-terminal", "go_ids": [], "go_terms": [], "name": "FADK_N", "pathway_ids": ["R-HSA-5663213", "R-HSA-8874081", "R-RNO-372708", "R-RNO-9020558", "R-RNO-9009391", "R-MMU-9009391", "R-MMU-4420097", "R-HSA-418885", "R-RNO-354194", "R-HSA-375165", "R-HSA-3928662", "R-RNO-2029482", "R-RNO-9860927", "R-RNO-111465", "R-RNO-8874081", "R-HSA-4420097", "R-RNO-5663213", "R-MMU-372708", "R-MMU-5663213", "R-MMU-8874081", "R-MMU-9013420", "R-RNO-354192", "R-RNO-3928662", "R-MMU-9020558", "R-RNO-375165", "R-MMU-375165", "R-RNO-5673001", "R-MMU-111465", "R-MMU-5673001", "R-HSA-9020558", "R-HSA-354192", "R-HSA-9664422", "R-HSA-9013420", "R-MMU-391160", "R-HSA-354194", "R-RNO-391160", "R-MMU-354194", "R-HSA-2029482", "R-HSA-9634638", "R-MMU-2029482", "R-RNO-418885", "R-HSA-5673001", "R-MMU-9860927", "R-HSA-9009391", "R-MMU-3928662", "R-HSA-111465", "R-HSA-9860927", "R-HSA-372708", "R-RNO-9013420", "R-MMU-354192", "R-RNO-4420097", "R-HSA-391160", "R-MMU-418885"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-418885:r:DCC mediated attractive signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-354192:r:Integrin signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9020558:r:Interleukin-2 signaling", "R-HSA-354192:r:Integrin signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-354192:r:Integrin signaling", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR041391": {"description": "Protein of unknown function DUF5570", "go_ids": [], "go_terms": [], "name": "DUF5570", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041392": {"description": "Beta-galactosidase, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "GHD", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR041393": {"description": "Sld3, N-terminal", "go_ids": [], "go_terms": [], "name": "Sld3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041394": {"description": "Cthe_2314-like HEPN", "go_ids": [], "go_terms": [], "name": "HEPN_Cthe2314", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041395": {"description": "McpB, third HAMP domain", "go_ids": [], "go_terms": [], "name": "McpB_HAMP_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041396": {"description": "Cysteine-rich protective antigen 6 bladed domain", "go_ids": [], "go_terms": [], "name": "CyRPA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041397": {"description": "ThiD2", "go_ids": [], "go_terms": [], "name": "ThiD2", "pathway_ids": ["PWY-8457", "PWY-6894", "PWY-6908", "PWY-6907", "PWY-7356", "PWY-6897", "PWY-6893"], "pathways": ["PWY-8457:t:thiamine diphosphate salvage V", "PWY-6894:t:thiamine diphosphate biosynthesis I (E. coli)", "PWY-6908:t:thiamine diphosphate biosynthesis IV (eukaryotes)", "PWY-6907:t:thiamine diphosphate biosynthesis III (Staphylococcus)", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)", "PWY-6897:t:thiamine diphosphate salvage II", "PWY-6893:t:thiamine diphosphate biosynthesis II (Bacillus)"], "type": "Domain"}, "IPR041398": {"description": "DdrB-like domain", "go_ids": [], "go_terms": [], "name": "DdrB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041399": {"description": "Large catalase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Catalase_large_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041400": {"description": "PARP16 N-terminal domain", "go_ids": [], "go_terms": [], "name": "PARP16_N", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein"], "type": "Domain"}, "IPR041401": {"description": "Cell wall elongation regulator TseB-like domain", "go_ids": [], "go_terms": [], "name": "TseB-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041402": {"description": "Dextranase, beta solenoid repeat", "go_ids": [], "go_terms": [], "name": "B_solenoid_dext", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR041403": {"description": "DUF4458 domain-containing protein, leucine-rich repeat", "go_ids": [], "go_terms": [], "name": "DUF4458_prot_LRR", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR041404": {"description": "Protein of unknown function DUF5588", "go_ids": [], "go_terms": [], "name": "DUF5588", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041405": {"description": "Type III R-M EcoP15I, C-terminal", "go_ids": [], "go_terms": [], "name": "T3RM_EcoP15I_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041406": {"description": "COP9 signalosome complex subunit 4, helix turn helix domain", "go_ids": [], "go_terms": [], "name": "CSN4_HTH", "pathway_ids": ["R-RNO-6781823", "R-SSC-6781823", "R-BTA-8951664", "R-DRE-8856825", "R-DME-8856825", "R-HSA-9013422", "R-RNO-8856825", "R-RNO-9013422", "R-MMU-8856825", "R-DME-6781823", "R-BTA-5696394", "R-HSA-8951664", "R-DME-8951664", "R-DRE-8951664", "R-SSC-8951664", "R-DME-9013422", "R-DRE-5696394", "R-DME-5696394", "R-RNO-5696394", "R-BTA-9013422", "R-HSA-6781823", "R-MMU-8951664", "R-BTA-8856825", "R-MMU-6781823", "R-MMU-9013422", "R-BTA-6781823", "R-HSA-8856825", "R-RNO-8951664", "R-HSA-5696394", "R-SSC-8856825", "R-SSC-9013422", "R-MMU-5696394", "R-DRE-9013422", "R-DRE-6781823"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-8951664:r:Neddylation", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-SSC-8951664:r:Neddylation", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8951664:r:Neddylation", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex"], "type": "Domain"}, "IPR041407": {"description": "MazG, C-terminal", "go_ids": [], "go_terms": [], "name": "MazG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041408": {"description": "Hemolysin coregulated protein (Hcp) TssD", "go_ids": ["GO:0033104"], "go_terms": ["GO:0033104:type VI protein secretion system complex:C"], "name": "Hcp_Tssd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041409": {"description": "Restriction endonuclease AspBHI, N-terminal", "go_ids": [], "go_terms": [], "name": "RE_AspBHI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041410": {"description": "STATa immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "STATa_Ig", "pathway_ids": ["R-DDI-9008059", "R-DDI-9020591", "R-DDI-909733", "R-DDI-8984722", "R-DDI-3249367", "R-DDI-9020933", "R-DDI-8854691", "R-DDI-8985947", "R-DDI-877300", "R-DDI-9020956", "R-DDI-9860927", "R-DDI-1169408", "R-DDI-9833482", "R-DDI-6785807", "R-DDI-201556", "R-DDI-6783783", "R-DDI-1059683", "R-DDI-9701898", "R-DDI-8983432", "R-DDI-877312"], "pathways": ["R-DDI-9008059:r:Interleukin-37 signaling", "R-DDI-9020591:r:Interleukin-12 signaling", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-DDI-8984722:r:Interleukin-35 Signalling", "R-DDI-3249367:r:STAT6-mediated induction of chemokines", "R-DDI-9020933:r:Interleukin-23 signaling", "R-DDI-8854691:r:Interleukin-20 family signaling", "R-DDI-8985947:r:Interleukin-9 signaling", "R-DDI-877300:r:Interferon gamma signaling", "R-DDI-9020956:r:Interleukin-27 signaling", "R-DDI-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-9833482:r:PKR-mediated signaling", "R-DDI-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DDI-201556:r:Signaling by ALK", "R-DDI-6783783:r:Interleukin-10 signaling", "R-DDI-1059683:r:Interleukin-6 signaling", "R-DDI-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DDI-8983432:r:Interleukin-15 signaling", "R-DDI-877312:r:Regulation of IFNG signaling"], "type": "Domain"}, "IPR041411": {"description": "Linalool dehydratase/isomerase", "go_ids": [], "go_terms": [], "name": "Ldi", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041412": {"description": "Xrn1, helical domain", "go_ids": [], "go_terms": [], "name": "Xrn1_helical", "pathway_ids": ["R-MMU-450385", "R-MMU-6791226", "R-HSA-450385", "R-HSA-9930044", "R-MMU-450513", "R-HSA-9770562", "R-HSA-390471", "R-HSA-6791226", "R-HSA-450513", "R-SCE-450513", "R-GGA-6791226", "R-HSA-9918487", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-GGA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR041413": {"description": "MmyB-like transcription regulator ligand binding", "go_ids": [], "go_terms": [], "name": "MLTR_LBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041414": {"description": "RamQ-like, middle-like domain", "go_ids": [], "go_terms": [], "name": "RamQ-like_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041415": {"description": "BclA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BclA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041416": {"description": "IL-1Ra-like, immunoglobulin domain", "go_ids": [], "go_terms": [], "name": "IL-1RAcP-like_ig", "pathway_ids": ["PWY-5381", "R-HSA-9020702", "R-HSA-399956", "R-RNO-9020702", "R-MMU-6811558", "R-MMU-9012546", "R-RNO-1257604", "R-MMU-9020702", "R-MMU-9014843", "R-RNO-9014843", "R-MMU-388844", "R-RNO-399954", "R-HSA-388844", "R-RNO-6811558", "R-MMU-9014826", "R-MMU-399954", "R-HSA-399955", "R-HSA-9007892", "R-HSA-6783783", "R-RNO-399956", "R-MMU-9007892", "R-RNO-9014826", "R-DRE-9007892", "R-MMU-399955", "R-HSA-9679191", "R-MMU-1257604", "R-HSA-6811558", "R-HSA-9014843", "R-HSA-9014826", "R-RNO-9007892", "R-RNO-399955", "R-HSA-399954", "R-HSA-9012546", "R-RNO-388844", "R-HSA-1257604", "R-MMU-399956"], "pathways": ["PWY-5381:t:NAD salvage (plants)", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9012546:r:Interleukin-18 signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-9014843:r:Interleukin-33 signaling", "R-RNO-9014843:r:Interleukin-33 signaling", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9014826:r:Interleukin-36 pathway", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9007892:r:Interleukin-38 signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-MMU-9007892:r:Interleukin-38 signaling", "R-RNO-9014826:r:Interleukin-36 pathway", "R-DRE-9007892:r:Interleukin-38 signaling", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9014843:r:Interleukin-33 signaling", "R-HSA-9014826:r:Interleukin-36 pathway", "R-RNO-9007892:r:Interleukin-38 signaling", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9012546:r:Interleukin-18 signaling", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-399956:r:CRMPs in Sema3A signaling"], "type": "Domain"}, "IPR041417": {"description": "Probable aminopeptidase NPEPL1, N-terminal", "go_ids": [], "go_terms": [], "name": "NPEPL1_N", "pathway_ids": ["PWY-7694", "PWY-6423", "PWY-7954"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-6423:t:hemoglobin degradation", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis"], "type": "Domain"}, "IPR041418": {"description": "SAM domain", "go_ids": [], "go_terms": [], "name": "SAM_3", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR041419": {"description": "TnsE, C-terminal", "go_ids": [], "go_terms": [], "name": "TnsE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041420": {"description": "Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 4", "go_ids": [], "go_terms": [], "name": "PBECR4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041421": {"description": "Ubl4, C-terminal TUGS domain", "go_ids": [], "go_terms": [], "name": "Ubl4_C_TUGS", "pathway_ids": ["R-HSA-9609523"], "pathways": ["R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Domain"}, "IPR041422": {"description": "Protein of unknown function DUF5545", "go_ids": [], "go_terms": [], "name": "DUF5545", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041423": {"description": "DNA gyrase subunit B insert domain", "go_ids": [], "go_terms": [], "name": "GyrB_insert", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638771"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638771:r:Action of antimicrobials"], "type": "Domain"}, "IPR041424": {"description": "CinA, KH domain", "go_ids": [], "go_terms": [], "name": "CinA_KH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041425": {"description": "Complement C3/4/5, macroglobulin domain MG1", "go_ids": [], "go_terms": [], "name": "C3/4/5_MG1", "pathway_ids": ["R-HSA-6798695", "R-HSA-375276", "R-BTA-173736", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-418594", "R-RNO-977606", "R-BTA-8957275", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-381426", "R-BTA-977606", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors"], "type": "Domain"}, "IPR041426": {"description": "Mos1 transposase, HTH domain", "go_ids": [], "go_terms": [], "name": "Mos1_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041427": {"description": "AbiJ-NTD3", "go_ids": [], "go_terms": [], "name": "AbiJ-NTD3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041428": {"description": "Syntrophin, split Pleckstrin homology (PH) domain", "go_ids": [], "go_terms": [], "name": "PHsplit_syntrophin", "pathway_ids": ["R-HSA-9913351", "R-CEL-9913351", "R-MMU-9913351", "R-BTA-9913351"], "pathways": ["R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-BTA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Domain"}, "IPR041429": {"description": "Inositol-tetrakisphosphate 1-kinase, N-terminal", "go_ids": [], "go_terms": [], "name": "ITPK1_N", "pathway_ids": ["PWY-6366", "PWY-6554", "PWY-6362", "PWY-6372", "PWY-4661", "PWY-6365", "R-MMU-983231", "R-GGA-983231", "R-BTA-1855204", "R-HSA-1855167", "R-MMU-1855167", "R-HSA-1855204", "R-BTA-1855167", "R-HSA-983231", "R-GGA-1855167", "R-MMU-1855204", "R-GGA-1855204", "R-BTA-983231"], "pathways": ["PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6554:t:1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)", "PWY-6362:t:1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)", "PWY-6372:t:1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)", "PWY-4661:t:1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-GGA-1855167:r:Synthesis of pyrophosphates in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-GGA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR041430": {"description": "ATRX, ADD domain", "go_ids": [], "go_terms": [], "name": "ADD_ATRX", "pathway_ids": ["PWY-7250", "R-HSA-9670613", "R-MMU-9670095", "R-HSA-9670615", "R-HSA-9670095"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-9670613:r:Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-9670615:r:Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere"], "type": "Domain"}, "IPR041431": {"description": "Mvd1, C-terminal", "go_ids": [], "go_terms": [], "name": "Mvd1_C", "pathway_ids": ["PWY-7391", "PWY-922", "R-SCE-9969896", "R-DRE-9969896", "R-MMU-9969896", "R-SPO-446199", "R-BTA-446199", "R-SCE-446199", "R-DDI-446199", "R-RNO-9969896", "R-DRE-446199", "R-BTA-9969896", "R-DDI-9969896", "R-RNO-446199", "R-MMU-446199", "R-HSA-446199", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-DRE-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-446199:r:Synthesis of dolichyl-phosphate", "R-DDI-446199:r:Synthesis of dolichyl-phosphate", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-RNO-446199:r:Synthesis of dolichyl-phosphate", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR041432": {"description": "Ubiquitinyl hydrolase, variant UBP zinc finger", "go_ids": [], "go_terms": [], "name": "UBP13_Znf-UBP_var", "pathway_ids": ["R-GGA-5689880", "R-MMU-5689880", "R-BTA-8948751", "R-DRE-5689880", "R-DRE-8948751", "R-HSA-8866652", "R-GGA-8948751", "R-BTA-5689880", "R-HSA-5689880", "R-DDI-8948751", "R-HSA-8948751", "R-MMU-8948751", "R-MMU-8866652", "R-DDI-5689880", "R-DDI-8866652"], "pathways": ["R-GGA-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-DRE-5689880:r:Ub-specific processing proteases", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "type": "Domain"}, "IPR041433": {"description": "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal", "go_ids": [], "go_terms": [], "name": "RPN1_C", "pathway_ids": ["R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-HSA-174178", "R-RNO-8948751", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-MMU-8941858", "R-HSA-5689880", "R-BTA-1234176", "R-BTA-9755511", "R-HSA-8951664", "R-HSA-9010553", "R-HSA-75815", "R-MMU-174154", "R-MMU-69017", "R-RNO-382556", "R-RNO-5687128", "R-MMU-9020702", "R-MMU-8948751", "R-MMU-69481", "R-BTA-350562", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-BTA-75815", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-BTA-69601", "R-MMU-5668541", "R-HSA-8854050", "R-RNO-8854050", "R-BTA-5607761", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-RNO-450408", "R-MMU-174084", "R-BTA-68867", "R-HSA-211733", "R-HSA-1234176", "R-RNO-4641258", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-DDI-174084", "R-MMU-68867", "R-MMU-9932298", "R-MMU-1234176", "R-RNO-5689880", "R-MMU-4641258", "R-DDI-4641258", "R-RNO-8951664", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-HSA-1236974", "R-MMU-5687128", "R-RNO-5358346", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-RNO-69481", "R-DDI-187577", "R-RNO-6798695", "R-RNO-9932298", "R-HSA-68949", "R-BTA-1236978", "R-HSA-5610785", "R-RNO-5632684", "R-HSA-2467813", "R-RNO-1234176", "R-DDI-382556", "R-RNO-5676590", "R-BTA-195253", "R-MMU-187577", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-RNO-174178", "R-RNO-69601", "R-MMU-68949", "R-BTA-4608870", "R-BTA-5676590", "R-HSA-9824272", "R-DDI-174178", "R-MMU-174178", "R-MMU-349425", "R-MMU-8939236", "R-BTA-2871837", "R-HSA-9907900", "R-BTA-174154", "R-RNO-4641257", "R-DDI-5689603", "R-DDI-69601", "R-DDI-2467813", "R-BTA-174184", "R-RNO-349425", "R-MMU-9762114", "R-HSA-9762114", "R-DDI-5689880", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-BTA-8939236", "R-HSA-5610780", "R-MMU-382556", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-187577", "R-BTA-9931269", "R-DDI-9907900", "R-RNO-9755511", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-RNO-174113", "R-BTA-9929356", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-8939902", "R-RNO-187577", "R-MMU-174184", "R-RNO-68867", "R-MMU-8939902", "R-RNO-350562", "R-RNO-9762114", "R-BTA-9954709", "R-RNO-69017", "R-RNO-195253", "R-HSA-8939236", "R-HSA-5358346", "R-SPO-350562", "R-BTA-983168", "R-HSA-6798695", "R-DDI-8854050", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-BTA-5610785", "R-MMU-5607764", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-BTA-5668541", "R-BTA-6798695", "R-HSA-9766229", "R-HSA-5676590", "R-DDI-1236978", "R-DDI-8951664", "R-DDI-5632684", "R-MMU-8951664", "R-BTA-9929491", "R-RNO-174154", "R-HSA-4641257", "R-RNO-202424", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9929491", "R-MMU-9929356", "R-SCE-5668541", "R-RNO-5607761", "R-RNO-9929356", "R-HSA-68867", "R-MMU-9907900", "R-HSA-69481", "R-BTA-174084", "R-BTA-450408", "R-DDI-5658442", "R-BTA-5687128", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-HSA-9755511", "R-RNO-9931269", "R-HSA-4641258", "R-SPO-5689603", "R-RNO-8939236", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-RNO-174184", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-HSA-4608870", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-RNO-2467813", "R-RNO-983168", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-SPO-6798695", "R-HSA-187577", "R-MMU-5610780", "R-DDI-9755511", "R-BTA-382556", "R-BTA-8941858", "R-HSA-349425", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-DDI-75815", "R-MMU-350562", "R-MMU-69601", "R-HSA-2871837", "R-RNO-5689603", "R-BTA-2467813", "R-RNO-5610780", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-MMU-5658442", "R-RNO-8852276", "R-MMU-5689603", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-HSA-5607764", "R-RNO-1236978", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-BTA-8948751", "R-RNO-9907900", "R-RNO-4608870", "R-RNO-9929491", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-SCE-9907900", "R-BTA-5689603", "R-HSA-5668541", "R-HSA-9929356", "R-DDI-983168", "R-DDI-349425", "R-HSA-5687128", "R-RNO-8941858", "R-RNO-5607764", "R-HSA-69017", "R-RNO-1169091", "R-BTA-9020702", "R-RNO-5658442", "R-RNO-9766229", "R-RNO-5610785", "R-BTA-5607764", "R-DDI-450408", "R-MMU-983168", "R-MMU-1236978", "R-HSA-350562", "R-HSA-202424", "R-DDI-174154", "R-RNO-2871837"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-5689880:r:Ub-specific processing proteases", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of 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"R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-68949:r:Orc1 removal from chromatin", 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"R-DME-111458:r:Formation of apoptosome", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR041453": {"description": "Suv3, N-terminal", "go_ids": [], "go_terms": [], "name": "Suv3_N", "pathway_ids": ["R-HSA-9836573"], "pathways": ["R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Domain"}, "IPR041454": {"description": "BsuBI/PstI restriction endonuclease, HTH domain", "go_ids": [], "go_terms": [], "name": "BsuBI/PstI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041457": {"description": "CxC2-like cysteine cluster, KDZ transposase-associated", "go_ids": [], "go_terms": [], "name": "CxC2_KDZ-assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041458": {"description": "Rv3651-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Rv3651-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041459": {"description": "Polyvalent protein, metallopeptidase domain", "go_ids": [], "go_terms": [], "name": "MPTase-PolyVal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041460": {"description": "Molybdopterin oxidoreductase, N-terminal", "go_ids": [], "go_terms": [], "name": "Molybdopterin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041461": {"description": "CdvA-like coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CdvA_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041462": {"description": "Bacterial Alpha-2-macroglobulin, MG6 domain", "go_ids": [], "go_terms": [], "name": "Bact_A2M_MG6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041463": {"description": "LidA long coiled-coil domain", "go_ids": [], "go_terms": [], "name": "LidA_long_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041464": {"description": "TubC, N-terminal docking domain", "go_ids": [], "go_terms": [], "name": "TubC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041465": {"description": "SfsA, N-terminal OB domain", "go_ids": [], "go_terms": [], "name": "SfsA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041466": {"description": "Dynein heavy chain, AAA 5 extension domain", "go_ids": [], "go_terms": [], "name": "Dhc_AAA5_ext", "pathway_ids": ["R-MMU-380270", "R-HSA-9648025", "R-HSA-380270", "R-HSA-9609690", "R-RNO-5663220", "R-RNO-380259", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-MMU-8854518", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-MMU-6798695", "R-MMU-3371497", "R-HSA-380259", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-HSA-6798695", "R-SPO-6798695", "R-HSA-9646399", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-RNO-3371497", "R-DDI-9646399", "R-HSA-380284", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-68877", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-HSA-68877", "R-RNO-380284", "R-MMU-2132295", "R-MMU-5620912", "R-DME-6807878", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-5663220", "R-DDI-6798695", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-MMU-141444", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-PFA-9646399", "R-DME-6798695", "R-MMU-380259", "R-HSA-6807878", "R-CEL-6811436", "R-HSA-141444", "R-DME-9646399", "R-CEL-6807878"], "pathways": ["R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-380270:r:Recruitment of mitotic 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"PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565", "R-MMU-70921", "R-HSA-70921"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "R-MMU-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism"], "type": "Domain"}, "IPR041473": {"description": "CtsR, C-terminal dimerization domain", "go_ids": [], "go_terms": [], "name": "CtsR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041474": {"description": "HTH-type transcriptional repressor NicS, C-terminal", "go_ids": [], "go_terms": [], "name": "NicS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041475": {"description": "His-Me finger endonuclease, beta4-alpha2 domain", "go_ids": [], "go_terms": [], "name": "His_Me_b4a2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041476": {"description": "TRAF3-interacting protein 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TRAF3IP1_C", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR041477": {"description": "Domain of unknown function DUF5577", "go_ids": [], "go_terms": [], "name": "DUF5577", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041478": {"description": "Tetracyclin repressor-like, C-terminal domain 27", "go_ids": [], "go_terms": [], "name": "TetR_C_27", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041479": {"description": "TetR transcriptional regulator CgmR-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_CgmR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041480": {"description": "Cysteine-rich interdomain region 1 gamma", "go_ids": [], "go_terms": [], "name": "CIDR1_gamma", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041481": {"description": "COP9 signalosome complex subunit 7, helix I", "go_ids": ["GO:0010387", "GO:0008180"], "go_terms": ["GO:0010387:COP9 signalosome assembly:P", "GO:0008180:COP9 signalosome:C"], "name": "CSN7_helixI", "pathway_ids": 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recognition for clathrin-mediated endocytosis", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Domain"}, "IPR041482": {"description": "LSDAT, prokaryote", "go_ids": [], "go_terms": [], "name": "LSDAT_prok", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041483": {"description": "Tetracyclin repressor-like, C-terminal domain 34", "go_ids": [], "go_terms": [], "name": "TetR_C_34", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041484": {"description": "TetR transcriptional regulator Rv1219c-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_C_25", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041485": {"description": "QsdR, TetR regulatory C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_C_36", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041486": {"description": "NAD(+) hydrolase ThsA, Sir2/TIR-associating SLOG domain", "go_ids": [], "go_terms": [], "name": "ThsA_STALD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041487": {"description": "HEPN/Toprim N-terminal domain 1", "go_ids": [], "go_terms": [], "name": "HEPN/Toprim-NTD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041489": {"description": "PDZ domain 6", "go_ids": [], "go_terms": [], "name": "PDZ_6", "pathway_ids": ["R-XTR-9013106", "R-HSA-9013409", "R-HSA-9013405", "R-MMU-9837999", "R-MMU-9013106", "R-DRE-1474228", "R-MMU-8980692", "R-MMU-9013408", "R-CEL-9907900", "R-XTR-9013026", "R-HSA-9013106", "R-MMU-9013409", "R-MMU-9013404", "R-MMU-9013148", "R-HSA-6794361", "R-HSA-9013423", "R-HSA-9907900", "R-DME-9907900", "R-HSA-8853659", "R-HSA-9035034", "R-BTA-9837999", "R-HSA-9013148", "R-XTR-9696264", "R-XTR-9013423", "R-XTR-5610787", "R-HSA-9837999", "R-HSA-9013408", "R-BTA-9907900", "R-MMU-416993", "R-HSA-1474228", "R-XTR-9013409", "R-MMU-9035034", "R-MMU-9907900", "R-HSA-416993", "R-RNO-8853659", "R-DME-9837999", "R-MMU-6794361", "R-HSA-9841251", "R-MMU-8853659", "R-XTR-9013408", "R-XTR-9035034", "R-XTR-9013148", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-SCE-9907900", "R-HSA-9013149", "R-XTR-8980692", "R-XTR-9013404", "R-HSA-8980692", "R-XTR-9013406", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9013026", "R-HSA-9013406", "R-MMU-9696264", "R-RNO-6794361", "R-MMU-9013149", "R-RNO-416993"], "pathways": ["R-XTR-9013106:r:RHOC GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-DRE-1474228:r:Degradation of the extracellular matrix", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-CEL-9907900:r:Proteasome assembly", "R-XTR-9013026:r:RHOB GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-6794361:r:Neurexins and neuroligins", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9907900:r:Proteasome assembly", "R-DME-9907900:r:Proteasome assembly", "R-HSA-8853659:r:RET signaling", "R-HSA-9035034:r:RHOF GTPase cycle", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-XTR-9696264:r:RND3 GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-XTR-5610787:r:Hedgehog 'off' state", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-BTA-9907900:r:Proteasome assembly", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-8853659:r:RET signaling", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-8853659:r:RET signaling", "R-XTR-9013408:r:RHOG GTPase cycle", "R-XTR-9035034:r:RHOF GTPase cycle", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-XTR-8980692:r:RHOA GTPase cycle", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-RNO-6794361:r:Neurexins and neuroligins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors"], "type": "Domain"}, "IPR041490": {"description": "HTH-type transcriptional repressor KstR2, C-terminal", "go_ids": [], "go_terms": [], "name": "KstR2_TetR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041491": {"description": "TRPM, SLOG domain", "go_ids": [], "go_terms": [], "name": "TRPM_SLOG", "pathway_ids": ["R-HSA-6798695", "R-DME-3295583", "R-HSA-9717207", "R-RNO-3295583", "R-CEL-3295583", "R-DRE-6798695", "R-MMU-3295583", "R-MMU-6798695", "R-DRE-3295583", "R-HSA-9824594", "R-RNO-6798695", "R-HSA-3295583"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DME-3295583:r:TRP channels", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-3295583:r:TRP channels", "R-CEL-3295583:r:TRP channels", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-3295583:r:TRP channels", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-3295583:r:TRP channels", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-3295583:r:TRP channels"], "type": "Domain"}, "IPR041492": {"description": "Haloacid dehalogenase-like hydrolase", "go_ids": [], "go_terms": [], "name": "HAD_2", "pathway_ids": ["R-MMU-73614", "R-HSA-73614", "R-SCE-73614"], "pathways": ["R-MMU-73614:r:Pyrimidine salvage", "R-HSA-73614:r:Pyrimidine salvage", "R-SCE-73614:r:Pyrimidine salvage"], "type": "Family"}, "IPR041493": {"description": "PRDM4, zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "PRDM4_Znf", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-193670"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-193670:r:p75NTR negatively regulates cell cycle via SC1"], "type": "Domain"}, "IPR041494": {"description": "PIN-like domain", "go_ids": [], "go_terms": [], "name": "PIN7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041495": {"description": "Mub B2-like domain", "go_ids": [], "go_terms": [], "name": "Mub_B2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041496": {"description": "YitH/HolE, acetyltransferase (GNAT) domain", "go_ids": [], "go_terms": [], "name": "YitH/HolE_GNAT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041497": {"description": "THUMP-like domain", "go_ids": [], "go_terms": [], "name": "Thump-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041498": {"description": "Bacterial Ig domain", "go_ids": [], "go_terms": [], "name": "Big_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041499": {"description": "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain", "go_ids": [], "go_terms": [], "name": "Tfc1/Sfc1_N", "pathway_ids": ["R-SCE-76066", "R-DDI-76066", "R-DDI-76061", "R-SPO-76066", "R-HSA-76066", "R-MMU-76061", "R-HSA-76061", "R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR041500": {"description": "RecBCD enzyme subunit RecC, C-terminal", "go_ids": [], "go_terms": [], "name": "RecC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041501": {"description": "Defence against restriction A, C-terminal", "go_ids": [], "go_terms": [], "name": "DarA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041502": {"description": "SMODS/Ubiquitin system-associated 2TM effector domain", "go_ids": [], "go_terms": [], "name": "SUa-2TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041503": {"description": "AIMP2, thioredoxin-like domain", "go_ids": [], "go_terms": [], "name": "AIMP2_thioredoxin", "pathway_ids": ["R-MMU-9856649", "R-HSA-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-HSA-379716", "R-RNO-9856649", "R-DME-9856649"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Domain"}, "IPR041504": {"description": "Adaptive response protein AidB, N-terminal", "go_ids": [], "go_terms": [], "name": "AidB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041505": {"description": "Dis3-like cold-shock domain 2", "go_ids": [], "go_terms": [], "name": "Dis3_CSD2", "pathway_ids": ["R-MMU-9930044", "R-MMU-450385", "R-MMU-6791226", "R-HSA-9930044", "R-CEL-450385", "R-SCE-450513", "R-MMU-429958", "R-SPO-9930044", "R-CEL-450513", "R-SCE-450385", "R-HSA-9820865", "R-HSA-450385", "R-SCE-429958", "R-HSA-380994", "R-MMU-450513", "R-CEL-429958", "R-MMU-450604", "R-HSA-6791226", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-HSA-429958", "R-SPO-429958"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Domain"}, "IPR041506": {"description": "Domain of unknown function DUF5645", "go_ids": [], "go_terms": [], "name": "DUF5645", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041507": {"description": "Peptidase C12, C-terminal domain", "go_ids": [], "go_terms": [], "name": "UCH_C", "pathway_ids": ["R-MMU-5693565", "R-DRE-5689603", "R-RNO-5689603", "R-BTA-5689603", "R-SSC-5689603", "R-CEL-5689603", "R-DDI-5689603", "R-DME-5689603", "R-RNO-5693565", "R-HSA-5689603", "R-MMU-5689603", "R-HSA-5693565", "R-HSA-2173788", "R-SPO-5689603", "R-DDI-5693565", "R-XTR-5689603"], "pathways": ["R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5689603:r:UCH proteinases", "R-RNO-5689603:r:UCH proteinases", "R-BTA-5689603:r:UCH proteinases", "R-SSC-5689603:r:UCH proteinases", "R-CEL-5689603:r:UCH proteinases", "R-DDI-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SPO-5689603:r:UCH proteinases", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-XTR-5689603:r:UCH proteinases"], "type": "Domain"}, "IPR041508": {"description": "Toxin complex C-like repeat", "go_ids": [], "go_terms": [], "name": "TcC-like_repeat", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR041509": {"description": "Glycosyl hydrolases 38, beta-1 domain", "go_ids": [], "go_terms": [], "name": "GH38_beta-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041510": {"description": "Domain of unknown function DUF5523", "go_ids": [], "go_terms": [], "name": "DUF5523", "pathway_ids": ["R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR041511": {"description": "Putative DNA-binding domain", "go_ids": [], "go_terms": [], "name": "DBD_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041512": {"description": "APOBEC3H", "go_ids": [], "go_terms": [], "name": "APOBEC3H", "pathway_ids": ["R-HSA-72200", "R-HSA-75094"], "pathways": ["R-HSA-72200:r:mRNA Editing: C to U Conversion", "R-HSA-75094:r:Formation of the Editosome"], "type": "Family"}, "IPR041513": {"description": "SAS-6 coiled-coil domain", "go_ids": [], "go_terms": [], "name": "SAS6_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041514": {"description": "L-glutamate gamma-semialdehyde dehydrogenase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "GSALDH-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041515": {"description": "PPAF-2-like, Clip domain", "go_ids": [], "go_terms": [], "name": "PPAF-2-like_Clip", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041516": {"description": "LACTB2, winged helix domain", "go_ids": [], "go_terms": [], "name": "LACTB2_WH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041517": {"description": "Protease Do-like, PDZ domain", "go_ids": [], "go_terms": [], "name": "DEGP_PDZ", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR041518": {"description": "Glycosyl hydrolase family 3, C-terminal, bacteria", "go_ids": [], "go_terms": [], "name": "GH3_C_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041519": {"description": "RiboL-PSP-HEPN", "go_ids": [], "go_terms": [], "name": "HEPN_RiboL-PSP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041522": {"description": "CdaR, GGDEF-like domain", "go_ids": [], "go_terms": [], "name": "CdaR_GGDEF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041523": {"description": "Roquin II", "go_ids": [], "go_terms": [], "name": "ROQ_II", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR041524": {"description": "Glycoside hydrolase 131, catalytic N-terminal", "go_ids": [], "go_terms": [], "name": "GH131_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041525": {"description": "Nicotinate/nicotinamide phosphoribosyltransferase", "go_ids": [], "go_terms": [], "name": "N/Namide_PRibTrfase", "pathway_ids": ["PWY-5381", "R-MMU-196807", "R-DDI-6798695", "R-DME-196807", "R-DME-6798695", "R-CEL-6798695", "R-CEL-196807", "R-HSA-196807", "R-DDI-196807", "R-HSA-1368108", "R-RNO-196807", "R-HSA-9768919", "R-SSC-196807"], "pathways": ["PWY-5381:t:NAD salvage (plants)", "R-MMU-196807:r:Nicotinate metabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-196807:r:Nicotinate metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-DDI-196807:r:Nicotinate metabolism", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-196807:r:Nicotinate metabolism", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-SSC-196807:r:Nicotinate metabolism"], "type": "Domain"}, "IPR041526": {"description": "DAPG hydrolase, PhiG domain", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "DAPG_hydrolase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041527": {"description": "YhcG, N-terminal", "go_ids": [], "go_terms": [], "name": "YhcG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041528": {"description": "Cas6b N-terminal", "go_ids": [], "go_terms": [], "name": "Cas6b_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041529": {"description": "Nicotinamide phosphoribosyltransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF5598", "pathway_ids": ["R-MMU-196807", "R-HSA-196807", "R-HSA-1368108", "R-RNO-196807", "R-HSA-9768919", "R-SSC-196807"], "pathways": ["R-MMU-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-196807:r:Nicotinate metabolism", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-SSC-196807:r:Nicotinate metabolism"], "type": "Domain"}, "IPR041530": {"description": "Oligosaccharyltransferase insert domain", "go_ids": [], "go_terms": [], "name": "OST_IS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041531": {"description": "Baseplate upper protein, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "BppU_IgG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041532": {"description": "RlmI-like, PUA domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "RlmI-like_PUA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041533": {"description": "Bartonella effector protein, BID domain", "go_ids": [], "go_terms": [], "name": "Bep_BID", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041534": {"description": "PP2A regulatory subunit B'', EF-hand domain", "go_ids": [], "go_terms": [], "name": "EF-hand_13", "pathway_ids": ["R-HSA-69273", "R-HSA-113501", "R-MMU-113501", "R-MMU-69273", "R-HSA-69231", "R-MMU-69231"], "pathways": ["R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Domain"}, "IPR041535": {"description": "Antitoxin VbhA", "go_ids": [], "go_terms": [], "name": "VbhA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041536": {"description": "N-acetylglucosamine-1-phosphotransferase subunit alpha/beta, regulatory domain", "go_ids": [], "go_terms": [], "name": "GNPTAB_reg", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041537": {"description": "Protein of of unknown function DUF5547", "go_ids": [], "go_terms": [], "name": "DUF5547", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041538": {"description": "ATPase RavA-like, AAA lid domain", "go_ids": [], "go_terms": [], "name": "RavA-like_AAA_lid", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR041539": {"description": "CxC5 like cysteine cluster associated with KDZ", "go_ids": [], "go_terms": [], "name": "CxC5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041540": {"description": "Vms1-associating treble clef domain", "go_ids": [], "go_terms": [], "name": "VATC", "pathway_ids": ["R-HSA-9954709"], "pathways": ["R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR041541": {"description": "Glutaminase, EF-hand domain", "go_ids": [], "go_terms": [], "name": "Glutaminase_EF-hand", "pathway_ids": ["PWY-5921", "R-HSA-8964539", "R-RNO-8964539", "R-MMU-8964539", "R-RNO-210500", "R-MMU-5628897", "R-RNO-5628897", "R-CEL-5628897", "R-MMU-210500", "R-CEL-210500", "R-CEL-8964539", "R-HSA-210500", "R-HSA-5628897"], "pathways": ["PWY-5921:t:glutaminyl-tRNAgln biosynthesis via transamidation", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Domain"}, "IPR041542": {"description": "Beta-xylosidase, C-terminal Concanavalin A-like domain", "go_ids": [], "go_terms": [], "name": "GH43_C2", "pathway_ids": ["PWY-6717"], "pathways": ["PWY-6717:t:(1,4)-beta-D-xylan degradation"], "type": "Domain"}, "IPR041543": {"description": "Domain of unknown function DUF5644", "go_ids": [], "go_terms": [], "name": "DUF5644", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041544": {"description": "MotY N-terminal domain", "go_ids": [], "go_terms": [], "name": "MotY_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041545": {"description": "RABX5, catalytic core helical domain", "go_ids": [], "go_terms": [], "name": "DUF5601", "pathway_ids": ["R-BTA-8856828", "R-MMU-8856828", "R-MMU-8876198", "R-HSA-8854214", "R-HSA-8856828", "R-BTA-8876198", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198"], "pathways": ["R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR041546": {"description": "ClpA/ClpB, AAA lid domain", "go_ids": [], "go_terms": [], "name": "ClpA/ClpB_AAA_lid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041547": {"description": "C->U-editing enzyme APOBEC-1", "go_ids": [], "go_terms": [], "name": "APOBEC1", "pathway_ids": ["PWY-7081", "R-RNO-72200", "R-RNO-75094", "R-MMU-75094", "R-MMU-72200", "R-HSA-75094", "R-HSA-72200"], "pathways": ["PWY-7081:t:4-aminophenol degradation", "R-RNO-72200:r:mRNA Editing: C to U Conversion", "R-RNO-75094:r:Formation of the Editosome", "R-MMU-75094:r:Formation of the Editosome", "R-MMU-72200:r:mRNA Editing: C to U Conversion", "R-HSA-75094:r:Formation of the Editosome", "R-HSA-72200:r:mRNA Editing: C to U Conversion"], "type": "Family"}, "IPR041549": {"description": "Immunomodulating metalloprotease, helical domain", "go_ids": [], "go_terms": [], "name": "ImpA_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041550": {"description": "Fatty acid synthase type I, helical", "go_ids": [], "go_terms": [], "name": "FASI_helical", "pathway_ids": ["PWY-8174", "PWY-8427", "PWY-8280", "PWY-6519", "PWY-8203", "PWY-7663", "PWY-5367", "PWY-5989", "PWY-5966", "PWY-5971", "PWY-8173", "PWY-6113", "PWY-7664", "PWY-8175", "PWY-7858", "PWYG-321", "PWY-7388", "PWY-5994", "PWY-5973", "PWY-8279", "PWY-6282"], "pathways": ["PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWY-5367:t:petroselinate biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "PWY-6113:t:superpathway of mycolate biosynthesis", "PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWYG-321:t:mycolate biosynthesis", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8279:t:palmitate biosynthesis III", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"], "type": "Domain"}, "IPR041551": {"description": "BsaWI restriction endonuclease type 2", "go_ids": [], "go_terms": [], "name": "RE_BsaWI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041552": {"description": "UvrA, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "UvrA_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041553": {"description": "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain", "go_ids": [], "go_terms": [], "name": "Nup214_FG", "pathway_ids": ["R-HSA-9610379", "R-HSA-180910", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-HSA-450520", "R-HSA-4085377", "R-HSA-168325", "R-HSA-1169408", "R-HSA-170822", "R-HSA-9609690", "R-HSA-159227", "R-HSA-159231", "R-HSA-159230", "R-HSA-168333", "R-HSA-3232142", "R-HSA-3301854", "R-HSA-3371453", "R-HSA-5619107", "R-HSA-165054", "R-HSA-4570464", "R-HSA-159236", "R-HSA-180746", "R-HSA-4615885", "R-HSA-4551638"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-191859:r:snRNP Assembly", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-180746:r:Nuclear import of Rev protein", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins"], "type": "Domain"}, "IPR041555": {"description": "Macroglobulin domain MG3", "go_ids": [], "go_terms": [], "name": "MG3", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-MMU-163125", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-163125", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR041556": {"description": "Disulfide isomerase DsbG, N-terminal", "go_ids": [], "go_terms": [], "name": "DsbG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041558": {"description": "Mucin binding domain", "go_ids": [], "go_terms": [], "name": "MucBP_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041559": {"description": "DNA ligase, ATP-dependent, bacteriophage T7-type, C-terminal", "go_ids": ["GO:0003690"], "go_terms": ["GO:0003690:double-stranded DNA binding:F"], "name": "DNA_ligase_ATP-dep_T7_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041560": {"description": "FMR1, tudor domain", "go_ids": [], "go_terms": [], "name": "Tudor_FRM1", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR041561": {"description": "PglD, N-terminal", "go_ids": [], "go_terms": [], "name": "PglD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041562": {"description": "MCM, AAA-lid domain", "go_ids": [], "go_terms": [], "name": "MCM_lid", "pathway_ids": ["R-XTR-69052", "R-RNO-68949", "R-HSA-9825895", "R-GGA-68689", "R-RNO-68962", "R-SPO-68867", "R-HSA-68949", "R-HSA-176974", "R-CEL-68962", "R-XTR-68689", "R-HSA-113507", "R-BTA-68949", "R-MMU-68949", "R-RNO-176187", "R-DME-69052", "R-CEL-68867", "R-BTA-68962", "R-SCE-69052", "R-BTA-176187", "R-DME-68962", "R-DDI-68962", "R-HSA-69052", "R-GGA-68949", "R-HSA-68962", "R-CEL-69052", "R-SCE-176187", "R-SCE-68867", "R-BTA-68689", "R-HSA-176187", "R-BTA-68867", "R-RNO-68689", "R-DME-68949", "R-GGA-68962", "R-HSA-68867", "R-DME-176187", "R-DDI-68867", "R-SPO-176187", "R-MMU-68867", "R-XTR-68962", "R-MMU-68962", "R-BTA-69052", "R-DME-68867", "R-SPO-69052", "R-HSA-68689", "R-SCE-68962", "R-DME-68689", "R-CEL-68949", "R-XTR-68949", "R-XTR-68867", "R-DDI-68949", "R-MMU-176187", "R-DDI-69052", "R-SPO-68962", "R-MMU-68689", "R-SPO-68949", "R-MMU-69052", "R-GGA-176187"], "pathways": ["R-XTR-69052:r:Switching of origins to a post-replicative state", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-GGA-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-SPO-68867:r:Assembly of the pre-replicative complex", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-176974:r:Unwinding of DNA", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-XTR-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-DME-69052:r:Switching of origins to a post-replicative state", "R-CEL-68867:r:Assembly of the pre-replicative complex", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-SCE-69052:r:Switching of origins to a post-replicative state", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-GGA-68949:r:Orc1 removal from chromatin", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-CEL-69052:r:Switching of origins to a post-replicative state", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68867:r:Assembly of the pre-replicative complex", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68949:r:Orc1 removal from chromatin", "R-GGA-68962:r:Activation of the pre-replicative complex", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DDI-68867:r:Assembly of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-BTA-69052:r:Switching of origins to a post-replicative state", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-SPO-69052:r:Switching of origins to a post-replicative state", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-68949:r:Orc1 removal from chromatin", "R-XTR-68949:r:Orc1 removal from chromatin", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-DDI-69052:r:Switching of origins to a post-replicative state", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-68949:r:Orc1 removal from chromatin", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-GGA-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR041563": {"description": "STT3 subunit PglB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "STT3_PglB_C", "pathway_ids": ["PWY-7031"], "pathways": ["PWY-7031:t:protein N-glycosylation (bacterial)"], "type": "Domain"}, "IPR041564": {"description": "Sld7, N-terminal", "go_ids": [], "go_terms": [], "name": "Sld7_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041565": {"description": "Parkin, RING/Ubox like zinc-binding domain", "go_ids": [], "go_terms": [], "name": "Parkin_Znf-RING", "pathway_ids": ["R-DME-983168", "R-HSA-9646399", "R-RNO-5205685", "R-HSA-5689877", "R-HSA-977225", "R-HSA-5675482", "R-DME-5689877", "R-MMU-5675482", "R-DME-9646399", "R-HSA-983168", "R-MMU-5205685", "R-MMU-9646399", "R-MMU-5689877", "R-DME-5205685", "R-RNO-5689877", "R-MMU-983168", "R-RNO-9646399", "R-RNO-5675482", "R-HSA-5205685", "R-RNO-983168"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9646399:r:Aggrephagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-5689877:r:Josephin domain DUBs", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-DME-5689877:r:Josephin domain DUBs", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DME-9646399:r:Aggrephagy", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-9646399:r:Aggrephagy", "R-MMU-5689877:r:Josephin domain DUBs", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-5689877:r:Josephin domain DUBs", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR041566": {"description": "Alpha-mannosidase 2, C-terminal sub-domain", "go_ids": [], "go_terms": [], "name": "AManII_C", "pathway_ids": ["R-DME-975578"], "pathways": ["R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway"], "type": "Domain"}, "IPR041567": {"description": "COI1, F-box", "go_ids": [], "go_terms": [], "name": "COI1_F-box", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041568": {"description": "TcA receptor binding domain", "go_ids": [], "go_terms": [], "name": "TcA_RBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041569": {"description": "AAA ATPase, AAA+ lid domain", "go_ids": [], "go_terms": [], "name": "AAA_lid_3", "pathway_ids": ["R-HSA-174178", "R-HSA-9604323", "R-BTA-5689880", "R-HSA-8951664", "R-HSA-9010553", "R-CEL-8941858", "R-CEL-532668", "R-CEL-5689877", "R-HSA-9668328", "R-SPO-5689880", "R-CEL-9013407", "R-MMU-5689880", "R-SCE-9603798", "R-DDI-9929491", "R-RNO-8854050", "R-HSA-450408", "R-SCE-5689880", "R-RNO-450408", "R-HSA-211733", "R-HSA-532668", "R-DDI-6798695", "R-DME-4641257", "R-DME-432524", "R-MMU-9013407", "R-DDI-204005", "R-HSA-162588", "R-MMU-1234176", "R-DDI-6811438", "R-MMU-8866910", "R-BTA-69017", "R-BTA-349425", "R-DDI-9668328", "R-DME-204005", "R-DDI-382556", "R-DME-202424", "R-DME-187577", "R-MMU-187577", "R-HSA-9735871", "R-HSA-9824272", "R-BTA-5676590", "R-BTA-4608870", "R-DRE-532668", "R-MMU-349425", "R-BTA-2871837", "R-DME-174084", "R-BTA-174154", "R-DDI-69601", "R-HSA-912446", "R-DME-9929491", "R-DDI-5689880", "R-DRE-5358346", "R-CEL-9755511", "R-DME-6798695", "R-RNO-9755511", "R-SPO-204005", "R-DME-174184", "R-BTA-9929356", "R-SPO-9755511", "R-MMU-5676590", "R-RNO-68867", "R-RNO-350562", "R-DME-9932298", "R-RNO-9762114", "R-SCE-9837999", "R-BTA-9954709", "R-CEL-9762114", "R-CEL-8951664", "R-MMU-9840373", "R-HSA-5358346", "R-HSA-6798695", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-BTA-5610785", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-BTA-6798695", "R-CEL-5358346", "R-DDI-8951664", "R-MMU-8951664", "R-CEL-5689603", "R-RNO-174154", "R-CEL-204005", "R-MMU-9929356", "R-XTR-9013407", "R-CEL-9668328", "R-DME-9762114", "R-HSA-69481", "R-BTA-174084", "R-DDI-8948751", "R-BTA-5358346", "R-XTR-6798695", "R-SPO-5689603", "R-MMU-6811440", "R-DME-1236978", "R-RNO-8939236", "R-HSA-180585", "R-SPO-1236978", "R-HSA-204005", "R-CEL-69017", "R-RNO-2467813", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-HSA-9013407", "R-RNO-9668328", "R-DME-8941858", "R-DRE-5689877", "R-SPO-6798695", "R-DRE-382556", "R-DME-416993", "R-BTA-382556", "R-CEL-8939902", "R-RNO-5610780", "R-DME-5689603", "R-DDI-6811440", "R-DME-216167", "R-MMU-5658442", "R-DRE-5689896", "R-CEL-6811438", "R-HSA-174084", "R-MMU-4608870", "R-BTA-5610780", "R-HSA-9840373", "R-RNO-9907900", "R-HSA-69601", "R-HSA-983168", "R-MMU-9033241", "R-BTA-5689603", "R-SPO-3371511", "R-DDI-349425", "R-RNO-8941858", "R-DDI-6807878", "R-HSA-69017", "R-RNO-1169091", "R-BTA-9020702", "R-SPO-9837999", "R-RNO-9766229", "R-MMU-1236978", "R-HSA-202424", "R-HSA-9033241", "R-CEL-4641257", "R-DDI-174154", "R-RNO-2871837", "R-RNO-917729", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-MMU-8941858", "R-MMU-917729", "R-MMU-174154", "R-CEL-195253", "R-DME-5658442", "R-MMU-9020702", "R-RNO-382556", "R-RNO-5687128", "R-MMU-5689896", "R-MMU-69481", "R-DME-5689896", "R-MMU-75815", "R-HSA-6811434", "R-MMU-5689877", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-HSA-8854050", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-BTA-68867", "R-RNO-6811440", "R-HSA-9929491", "R-RNO-9013407", "R-CEL-6807878", "R-RNO-5689880", "R-DRE-9755511", "R-RNO-8951664", "R-SPO-6811434", "R-DME-1234176", "R-HSA-1236974", "R-MMU-5687128", "R-RNO-5358346", "R-DME-5358346", "R-RNO-6798695", "R-HSA-68949", "R-MMU-9837999", "R-MMU-8852276", "R-BTA-68949", "R-MMU-68949", "R-RNO-9840373", "R-MMU-8949664", "R-DDI-2467813", "R-HSA-9837999", "R-RNO-349425", "R-BTA-174184", "R-HSA-5693568", "R-SSC-9668328", "R-BTA-8939236", "R-HSA-5610780", "R-HSA-416993", "R-SCE-1236978", "R-DME-432626", "R-SPO-6811440", "R-MMU-5607761", "R-CEL-5689880", "R-HSA-917729", "R-HSA-8939902", "R-DME-174178", "R-SCE-6811438", "R-RNO-195253", "R-MMU-204005", "R-DME-8951664", "R-HSA-9766229", "R-CEL-187577", "R-DME-6811438", "R-BTA-9929491", "R-BTA-9668328", "R-MMU-9929491", "R-BTA-9932298", "R-CEL-9603798", "R-HSA-68867", "R-HSA-9610379", "R-DME-174154", "R-MMU-9907900", "R-SCE-6811440", "R-DDI-5658442", "R-BTA-450408", "R-DME-110320", "R-HSA-8941858", "R-CEL-9929491", "R-DME-9755511", "R-SCE-9840373", "R-SPO-6811438", "R-MMU-2871837", "R-DME-5610785", "R-RNO-174084", "R-HSA-5689603", "R-RNO-983168", "R-BTA-8951664", "R-DME-1169091", "R-HSA-349425", "R-BTA-8941858", "R-DME-4641258", "R-HSA-174184", "R-MMU-350562", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-RNO-1236978", "R-DME-68949", "R-CEL-9954709", "R-BTA-8949664", "R-RNO-6807878", "R-HSA-382556", "R-HSA-8852276", "R-SPO-9840373", "R-RNO-9837999", "R-MMU-8876725", "R-DDI-983168", "R-XTR-9603798", "R-CEL-69601", "R-HSA-9929356", "R-RNO-5658442", "R-MMU-983168", "R-RNO-5610785", "R-HSA-350562", "R-DME-68867", "R-HSA-9646399", "R-MMU-6811438", "R-RNO-5668541", "R-MMU-9668328", "R-BTA-9755511", "R-HSA-75815", "R-SCE-204005", "R-HSA-9918487", "R-MMU-8948751", "R-DME-8948751", "R-CEL-1234176", "R-BTA-1169091", "R-BTA-69481", "R-MMU-3371511", "R-DME-5676590", "R-MMU-6811434", "R-HSA-5607761", "R-DDI-174084", "R-MMU-9932298", "R-RNO-3371511", "R-GGA-9668328", "R-HSA-8866654", "R-MMU-4641258", "R-DDI-4641258", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-SPO-8951664", "R-CEL-8948751", "R-MMU-9766229", "R-RNO-69481", "R-HSA-174154", "R-DDI-187577", "R-RNO-9932298", "R-RNO-1234176", "R-RNO-5632684", "R-SCE-5689896", "R-BTA-1236978", "R-RNO-174178", "R-DDI-6811434", "R-MMU-174178", "R-CEL-8854050", "R-DME-350562", "R-HSA-9907900", "R-XTR-9668328", "R-DDI-917729", "R-HSA-9762114", "R-HSA-195253", "R-DME-6811440", "R-BTA-187577", "R-DME-8939236", "R-RNO-174113", "R-XTR-110320", "R-DME-6811434", "R-MMU-174184", "R-RNO-187577", "R-SPO-110320", "R-DME-9020702", "R-RNO-69017", "R-DME-5689880", "R-SPO-350562", "R-RNO-416993", "R-XTR-532668", "R-HSA-5689896", "R-BTA-202424", "R-MMU-110320", "R-DDI-1236978", "R-DME-8939902", "R-CEL-382556", "R-RNO-5689877", "R-HSA-9678110", "R-DRE-6798695", "R-DRE-9013407", "R-DME-4608870", "R-SCE-5668541", "R-DME-6807878", "R-RNO-9929356", "R-SCE-6811434", "R-BTA-5687128", "R-RNO-6811438", "R-HSA-5678895", "R-SCE-9755511", "R-HSA-9694614", "R-HSA-4641258", "R-RNO-174184", "R-BTA-4641258", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-RNO-8949664", "R-MMU-5610780", "R-DME-9954709", "R-XTR-8876725", "R-MMU-9755511", "R-MMU-6807878", "R-HSA-6811440", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-SCE-9668328", "R-HSA-5362768", "R-DDI-9954709", "R-RNO-8852276", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-8948751", "R-SCE-6807878", "R-RNO-9929491", "R-HSA-1236978", "R-SPO-8876725", "R-RNO-110320", "R-DME-3371511", "R-MMU-912446", "R-HSA-5632684", "R-BTA-8854050", "R-XTR-5358346", "R-DRE-110320", "R-RNO-5607764", "R-XTR-9755511", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-XTR-5689896", "R-CEL-5632684", "R-HSA-5689880", "R-BTA-1234176", "R-MMU-69017", "R-BTA-350562", "R-CEL-110320", "R-XTR-9931269", "R-DME-2467813", "R-HSA-8949664", "R-HSA-1234176", "R-RNO-4641258", "R-MMU-68867", "R-HSA-9931269", "R-DRE-9931269", "R-DME-209461", "R-DRE-9603798", "R-SCE-8951664", "R-DME-75815", "R-RNO-5693568", "R-DME-69601", "R-CEL-4608870", "R-DME-69017", "R-DME-983168", "R-SCE-8876725", "R-HSA-5610785", "R-HSA-6811438", "R-HSA-2467813", "R-RNO-5676590", "R-BTA-195253", "R-SCE-6798695", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-DME-9907900", "R-RNO-4641257", "R-DDI-5689603", "R-CEL-75815", "R-MMU-532668", "R-DRE-9668328", "R-MMU-9762114", "R-HSA-5689877", "R-HSA-9603798", "R-MMU-195253", "R-MMU-202424", "R-MMU-382556", "R-DME-209360", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-RNO-75815", "R-MMU-1169091", "R-CEL-9931269", "R-XTR-8951664", "R-DME-8854050", "R-MMU-8939902", "R-BTA-917729", "R-XTR-382556", "R-HSA-8939236", "R-CEL-6811434", "R-DDI-8854050", "R-BTA-983168", "R-SPO-6807878", "R-MMU-5607764", "R-DRE-8951664", "R-BTA-5668541", "R-HSA-5676590", "R-DDI-5632684", "R-CEL-6811440", "R-SPO-9668328", "R-HSA-4641257", "R-BTA-9837999", "R-RNO-202424", "R-HSA-174113", "R-BTA-9762114", "R-MMU-5693568", "R-MMU-9603798", "R-RNO-5607761", "R-CEL-4641258", "R-CEL-9837999", "R-DME-9668328", "R-HSA-9755511", "R-RNO-9931269", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-RNO-532668", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-CEL-8949664", "R-RNO-5689896", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-HSA-3371511", "R-HSA-8876725", "R-HSA-187577", "R-DDI-9755511", "R-DME-382556", "R-DME-5610780", "R-RNO-9603798", "R-DME-195253", "R-MMU-69601", "R-HSA-8866910", "R-DME-5607761", "R-MMU-8854050", "R-SPO-5689896", "R-MMU-5689603", "R-HSA-5607764", "R-DME-9013407", "R-MMU-416993", "R-CEL-1236978", "R-RNO-4608870", "R-DRE-3371511", "R-RNO-6811434", "R-BTA-9603798", "R-DME-9837999", "R-HSA-6807878", "R-DME-532668", "R-RNO-204005", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-CEL-68949", "R-DME-5632684", "R-HSA-5687128", "R-DRE-8876725", "R-DME-432395", "R-DME-8949664", "R-SCE-3371511", "R-DDI-174178", "R-HSA-110320", "R-RNO-912446"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-5689877:r:Josephin domain DUBs", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SPO-5689880:r:Ub-specific processing proteases", "R-CEL-9013407:r:RHOH GTPase cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-9603798:r:Class I peroxisomal membrane protein import", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-MMU-9013407:r:RHOH GTPase cycle", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6811438:r:Intra-Golgi traffic", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-9824272:r:Somitogenesis", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-912446:r:Meiotic recombination", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-CEL-5689603:r:UCH proteinases", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-XTR-9013407:r:RHOH GTPase cycle", "R-CEL-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-XTR-6798695:r:Neutrophil degranulation", "R-SPO-5689603:r:UCH proteinases", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DRE-5689877:r:Josephin domain DUBs", "R-SPO-6798695:r:Neutrophil degranulation", "R-DRE-382556:r:ABC-family proteins mediated transport", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-5689603:r:UCH proteinases", "R-DDI-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-CEL-6811438:r:Intra-Golgi traffic", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9907900:r:Proteasome assembly", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-BTA-5689603:r:UCH proteinases", "R-SPO-3371511:r:HSF1 activation", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-1169091:r:Activation of 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degradation of PD-L1(CD274)", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-DRE-9603798:r:Class I peroxisomal membrane protein import", "R-SCE-8951664:r:Neddylation", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-8876725:r:Protein methylation", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-6811438:r:Intra-Golgi traffic", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-9907900:r:Proteasome assembly", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-9907900:r:Proteasome assembly", "R-RNO-4641257:r:Degradation of AXIN", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5689877:r:Josephin domain DUBs", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-XTR-8951664:r:Neddylation", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-XTR-382556:r:ABC-family proteins mediated transport", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6807878:r:COPI-mediated anterograde transport", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DRE-8951664:r:Neddylation", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-5632684:r:Hedgehog 'on' state", "R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-4641257:r:Degradation of AXIN", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-4641258:r:Degradation of DVL", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-DME-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-CEL-8949664:r:Processing of SMDT1", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-HSA-3371511:r:HSF1 activation", "R-HSA-8876725:r:Protein methylation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-9013407:r:RHOH GTPase cycle", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-DRE-3371511:r:HSF1 activation", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-BTA-9603798:r:Class I peroxisomal membrane protein import", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-68949:r:Orc1 removal from chromatin", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-8876725:r:Protein methylation", "R-DME-432395:r:Degradation of TIM", "R-DME-8949664:r:Processing of SMDT1", "R-SCE-3371511:r:HSF1 activation", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-RNO-912446:r:Meiotic recombination"], "type": "Domain"}, "IPR041571": {"description": "Protein of unknown function DUF5576", "go_ids": [], "go_terms": [], "name": "DUF5576", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041572": {"description": "Laterosporulin defensin-like peptide", "go_ids": [], "go_terms": [], "name": "Laterosporulin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041573": {"description": "Desmoplakin, spectrin-like domain", "go_ids": [], "go_terms": [], "name": "Desmoplakin_Spectrin-like", "pathway_ids": ["R-HSA-6798695", "R-HSA-6809371", "R-DRE-9696273", "R-RNO-351906", "R-HSA-9013424", "R-HSA-351906", "R-DRE-9696264", "R-MMU-9013420", "R-DRE-6798695", "R-RNO-6805567", "R-HSA-446107", "R-HSA-6805567", "R-RNO-6809371", "R-HSA-9013420", "R-RNO-446107", "R-MMU-446107", "R-HSA-9696270", "R-DRE-6805567", "R-DRE-6809371", "R-MMU-9013424", "R-MMU-351906", "R-RNO-9696273", "R-HSA-9696264", "R-MMU-6809371", "R-HSA-2022090", "R-MMU-264870", "R-RNO-9696264", "R-DRE-351906", "R-MMU-6798695", "R-RNO-264870", "R-MMU-9696264", "R-HSA-264870", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-6805567", "R-RNO-6798695", "R-HSA-9696273"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-DRE-9696273:r:RND1 GTPase cycle", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-9696264:r:RND3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6805567:r:Keratinization", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6805567:r:Keratinization", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-6805567:r:Keratinization", "R-DRE-6809371:r:Formation of the cornified envelope", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-6805567:r:Keratinization", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR041574": {"description": "Domain of unknown function DUF5608", "go_ids": [], "go_terms": [], "name": "DUF5608", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041575": {"description": "NADH-rubredoxin oxidoreductase, C-terminal", "go_ids": [], "go_terms": [], "name": "NROR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041576": {"description": "Virulence factor Evf", "go_ids": [], "go_terms": [], "name": "Evf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041577": {"description": "Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain", "go_ids": [], "go_terms": [], "name": "RT_RNaseH_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041578": {"description": "PIN like domain, group 8", "go_ids": [], "go_terms": [], "name": "PIN_8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041579": {"description": "Pelovaterin", "go_ids": [], "go_terms": [], "name": "Pelovaterin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041580": {"description": "Telomerase reverse transcriptase, thumb DNA-binding domain", "go_ids": [], "go_terms": [], "name": "TERT_thumb", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041581": {"description": "Glyoxalase-like domain, group 6", "go_ids": [], "go_terms": [], "name": "Glyoxalase_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041583": {"description": "Tetracyclin repressor-like, C-terminal, group 31", "go_ids": [], "go_terms": [], "name": "TetR_C_31", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041584": {"description": "Predicted pPIWI-associating nuclease, group 2", "go_ids": [], "go_terms": [], "name": "Put_pPIWI_pnuc_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041585": {"description": "LepB GAP domain, N-terminal subdomain", "go_ids": [], "go_terms": [], "name": "LepB_GAP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041586": {"description": "PsrA, tetracyclin repressor-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PsrA_TetR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041587": {"description": "Pesticidal crystal protein Cry, domain V", "go_ids": [], "go_terms": [], "name": "Cry_V", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041588": {"description": "Integrase zinc-binding domain", "go_ids": [], "go_terms": [], "name": "Integrase_H2C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041589": {"description": "Dynein heavy chain 3, AAA+ lid domain", "go_ids": [], "go_terms": [], "name": "DNAH3_AAA_lid_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041590": {"description": "O-phosphoserine--tRNA(Cys) ligase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SepRS_C", "pathway_ids": ["PWY-6308"], "pathways": ["PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)"], "type": "Domain"}, "IPR041591": {"description": "OCRE domain", "go_ids": [], "go_terms": [], "name": "OCRE", "pathway_ids": ["R-HSA-72163", "R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-HSA-9920588", "R-RNO-72203", "R-HSA-6802952", "R-MMU-9770562", "R-XTR-9770562", "R-RNO-9770562", "R-MMU-72163", "R-BTA-9770562", "R-RNO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-XTR-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-9770562:r:mRNA Polyadenylation", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR041595": {"description": "Inorganic pyrophosphatase domain", "go_ids": [], "go_terms": [], "name": "Inorganic_Pase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041596": {"description": "RNA ligase Pab1020, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Lig_Pab1020_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041597": {"description": "L,D-transpeptidase C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ldt_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041598": {"description": "Methionine--tRNA ligase, N-terminal", "go_ids": [], "go_terms": [], "name": "MARS_N", "pathway_ids": ["R-MMU-9856649", "R-HSA-379716", "R-HSA-9856649", "R-HSA-2408522"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism"], "type": "Domain"}, "IPR041599": {"description": "Phage protein Gp138 N-terminal domain", "go_ids": [], "go_terms": [], "name": "Gp138_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041600": {"description": "Effector immunity protein Tgi2PP", "go_ids": [], "go_terms": [], "name": "Tgi2PP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041601": {"description": "Fluorescence recovery protein", "go_ids": ["GO:0042651"], "go_terms": ["GO:0042651:thylakoid membrane:C"], "name": "FRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041602": {"description": "Quercetin 2,3-dioxygenase, C-terminal cupin domain", "go_ids": [], "go_terms": [], "name": "Quercetinase_C", "pathway_ids": ["PWY-6848"], "pathways": ["PWY-6848:t:rutin degradation"], "type": "Domain"}, "IPR041603": {"description": "YvdT, C-terminal", "go_ids": [], "go_terms": [], "name": "YvdT_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041604": {"description": "STAT, EF-hand fold domain", "go_ids": [], "go_terms": [], "name": "EF-hand_12", "pathway_ids": ["R-DDI-9008059", "R-DDI-9020591", "R-DDI-909733", "R-DDI-8984722", "R-DDI-3249367", "R-DDI-9020933", "R-DDI-8854691", "R-DDI-8985947", "R-DDI-877300", "R-DDI-9020956", "R-DDI-9860927", "R-DDI-1169408", "R-DDI-9833482", "R-DDI-6785807", "R-DDI-201556", "R-DDI-6783783", "R-DDI-1059683", "R-DDI-9701898", "R-DDI-8983432", "R-DDI-877312"], "pathways": ["R-DDI-9008059:r:Interleukin-37 signaling", "R-DDI-9020591:r:Interleukin-12 signaling", "R-DDI-909733:r:Interferon alpha/beta signaling", "R-DDI-8984722:r:Interleukin-35 Signalling", "R-DDI-3249367:r:STAT6-mediated induction of chemokines", "R-DDI-9020933:r:Interleukin-23 signaling", "R-DDI-8854691:r:Interleukin-20 family signaling", "R-DDI-8985947:r:Interleukin-9 signaling", "R-DDI-877300:r:Interferon gamma signaling", "R-DDI-9020956:r:Interleukin-27 signaling", "R-DDI-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-9833482:r:PKR-mediated signaling", "R-DDI-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DDI-201556:r:Signaling by ALK", "R-DDI-6783783:r:Interleukin-10 signaling", "R-DDI-1059683:r:Interleukin-6 signaling", "R-DDI-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DDI-8983432:r:Interleukin-15 signaling", "R-DDI-877312:r:Regulation of IFNG signaling"], "type": "Domain"}, "IPR041605": {"description": "3'-5' exonuclease C-terminal domain", "go_ids": [], "go_terms": [], "name": "Exo_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041606": {"description": "Hydrogen maturase F dimerization domain", "go_ids": [], "go_terms": [], "name": "HydF_dimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041607": {"description": "HU domain fused to wHTH, Ig, or Glycine-rich motif", "go_ids": [], "go_terms": [], "name": "HU-HIG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041608": {"description": "Embryo surrounding factor 1, brassicaceae", "go_ids": ["GO:0010098"], "go_terms": ["GO:0010098:suspensor development:P"], "name": "ESF1_brassicaceae", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041609": {"description": "Phosphoribosylformylglycinamidine synthase, linker domain", "go_ids": [], "go_terms": [], "name": "PurL_linker", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-MMU-73817", "R-CEL-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis"], "type": "Domain"}, "IPR041610": {"description": "ArlS, sensor domain", "go_ids": [], "go_terms": [], "name": "ArlS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041611": {"description": "SKICH domain", "go_ids": [], "go_terms": [], "name": "SKICH", "pathway_ids": ["R-CEL-8856828", "R-RNO-5357905", "R-HSA-936440", "R-HSA-1660499", "R-MMU-1660499", "R-HSA-5357905", "R-BTA-936440", "R-RNO-1660499", "R-MMU-5357905", "R-RNO-936440", "R-HSA-1855204", "R-CEL-1660499", "R-HSA-1855183", "R-RNO-1855204", "R-MMU-936440", "R-MMU-1855183", "R-MMU-1855204", "R-BTA-5357905", "R-RNO-1855183"], "pathways": ["R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol"], "type": "Domain"}, "IPR041612": {"description": "YfiR, C-terminal", "go_ids": [], "go_terms": [], "name": "YfiR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041613": {"description": "Peptidase S41, N-terminal", "go_ids": [], "go_terms": [], "name": "Pept_S41_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041614": {"description": "DprA, winged helix domain", "go_ids": [], "go_terms": [], "name": "DprA_WH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041615": {"description": "Desmoplakin, SH3 domain", "go_ids": [], "go_terms": [], "name": "Desmoplakin_SH3", "pathway_ids": ["R-HSA-6798695", "R-HSA-6809371", "R-DRE-9696273", "R-HSA-8851680", "R-RNO-351906", "R-HSA-9013424", "R-HSA-351906", "R-DRE-9696264", "R-MMU-9013420", "R-DRE-6798695", "R-RNO-6805567", "R-HSA-446107", "R-HSA-6805567", "R-RNO-6809371", "R-HSA-9013420", "R-RNO-446107", "R-MMU-446107", "R-HSA-9696270", "R-DRE-6805567", "R-DRE-6809371", "R-MMU-9013424", "R-MMU-351906", "R-RNO-9696273", "R-HSA-9696264", "R-MMU-8851680", "R-MMU-6809371", "R-HSA-2022090", "R-MMU-264870", "R-RNO-9696264", "R-DRE-351906", "R-MMU-6798695", "R-RNO-264870", "R-MMU-9696264", "R-HSA-264870", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-6805567", "R-RNO-6798695", "R-HSA-9696273"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-DRE-9696273:r:RND1 GTPase cycle", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-RNO-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-9696264:r:RND3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6805567:r:Keratinization", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-6805567:r:Keratinization", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-446107:r:Type I hemidesmosome assembly", "R-MMU-446107:r:Type I hemidesmosome assembly", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DRE-6805567:r:Keratinization", "R-DRE-6809371:r:Formation of the cornified envelope", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-9696264:r:RND3 GTPase cycle", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-6805567:r:Keratinization", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR041616": {"description": "Phenylalanyl tRNA synthetase beta chain, core domain", "go_ids": [], "go_terms": [], "name": "PheRS_beta_core", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR041617": {"description": "MalT-like TPR region", "go_ids": [], "go_terms": [], "name": "TPR_MalT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041618": {"description": "Polyketide synthase dimerisation element domain", "go_ids": [], "go_terms": [], "name": "PKS_DE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041619": {"description": "Nicotinate phosphoribosyltransferase C-terminal domain", "go_ids": [], "go_terms": [], "name": "NAPRTase_C", "pathway_ids": ["PWY-5381", "R-MMU-196807", "R-DDI-6798695", "R-HSA-6798695", "R-DRE-6798695", "R-DME-196807", "R-DME-6798695", "R-DRE-196807", "R-CEL-6798695", "R-CEL-196807", "R-HSA-196807", "R-MMU-6798695", "R-DDI-196807", "R-RNO-6798695", "R-RNO-196807"], "pathways": ["PWY-5381:t:NAD salvage (plants)", "R-MMU-196807:r:Nicotinate metabolism", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-196807:r:Nicotinate metabolism", "R-DME-6798695:r:Neutrophil degranulation", "R-DRE-196807:r:Nicotinate metabolism", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-196807:r:Nicotinate metabolism", "R-HSA-196807:r:Nicotinate metabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-196807:r:Nicotinate metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-196807:r:Nicotinate metabolism"], "type": "Domain"}, "IPR041620": {"description": "CdiA, C-terminal tRNase domain", "go_ids": [], "go_terms": [], "name": "CdiA_C_tRNase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041621": {"description": "Pyruvate dehydrogenase E1 component, middle domain", "go_ids": [], "go_terms": [], "name": "PDH_E1_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041622": {"description": "SMODS and SLOG-associating 2TM effector domain, fungi", "go_ids": [], "go_terms": [], "name": "SLATT_fungi", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041623": {"description": "NOG1, N-terminal helical domain", "go_ids": [], "go_terms": [], "name": "NOG1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041624": {"description": "Rhamnogalacturonan I lyase beta-sheet domain", "go_ids": [], "go_terms": [], "name": "RGI_lyase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041625": {"description": "Beta-mannosidase, Ig-fold domain", "go_ids": [], "go_terms": [], "name": "Beta-mannosidase_Ig", "pathway_ids": ["R-HSA-6798695", "R-MMU-6798695", "R-RNO-8853383", "R-MMU-8853383", "R-HSA-8853383", "R-CEL-8853383", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-CEL-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR041626": {"description": "Proteasomal ATPase, N-terminal OB domain", "go_ids": [], "go_terms": [], "name": "Prot_ATP_ID_OB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041627": {"description": "CbbX, AAA lid domain", "go_ids": [], "go_terms": [], "name": "AAA_lid_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041628": {"description": "ChlI/MoxR, AAA lid domain", "go_ids": [], "go_terms": [], "name": "ChlI/MoxR_AAA_lid", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Domain"}, "IPR041629": {"description": "Bacterial SCP orthologue", "go_ids": [], "go_terms": [], "name": "SCP_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041630": {"description": "Epithelial cell adhesion molecule N-terminal domain", "go_ids": [], "go_terms": [], "name": "EpCAM_N", "pathway_ids": ["R-HSA-9638630", "R-RNO-202733", "R-MMU-202733", "R-HSA-9927432", "R-HSA-9938206", "R-GGA-202733", "R-SSC-202733", "R-HSA-9927418", "R-HSA-202733", "R-HSA-9927426"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Domain"}, "IPR041631": {"description": "Alpha-dystroglycan N-terminal domain 2", "go_ids": [], "go_terms": [], "name": "Alpha_DG1_N2", "pathway_ids": ["R-MMU-8932505", "R-HSA-8932505", "R-CFA-9939291", "R-HSA-3000178", "R-HSA-8932504", "R-HSA-5083633", "R-HSA-3000171", "R-HSA-9913351", "R-HSA-9619665", "R-HSA-9010553", "R-MMU-9939291", "R-MMU-9010553", "R-CFA-9913351", "R-HSA-8932506", "R-MMU-9913351", "R-MMU-8932504", "R-CFA-9010553", "R-CFA-8932506", "R-CFA-8932504", "R-HSA-9939291", "R-HSA-5083629", "R-HSA-5083628", "R-CFA-8932505", "R-MMU-8932506"], "pathways": ["R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-CFA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-5083633:r:Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-CFA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-8932506:r:DAG1 core M1 glycosylations", "R-CFA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-5083629:r:Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "R-HSA-5083628:r:Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "R-CFA-8932505:r:DAG1 core M3 glycosylations", "R-MMU-8932506:r:DAG1 core M1 glycosylations"], "type": "Domain"}, "IPR041632": {"description": "Arsenite oxidase subunit AioA/Iodate reductase subunit IdrA, 3Fe-4S cluster", "go_ids": ["GO:0051536"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F"], "name": "AioA/IdrA_3Fe-4S", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041633": {"description": "MntA antitoxin-like, nucleotidyltransferase domain", "go_ids": [], "go_terms": [], "name": "MntA-like_nucleotrfase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041634": {"description": "Nuclear pore protein Nup188, C-terminal", "go_ids": [], "go_terms": [], "name": "Nup188_C", "pathway_ids": ["R-SPO-3371453", "R-SPO-4570464", "R-SPO-159236", "R-SPO-159227", "R-SPO-159231", "R-SPO-4551638", "R-SPO-9615933", "R-SPO-4085377"], "pathways": ["R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins"], "type": "Domain"}, "IPR041635": {"description": "Type ISP restriction-modification enzyme LLaBIII, C-terminal specificity domain", "go_ids": [], "go_terms": [], "name": "Type_ISP_LLaBIII_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041636": {"description": "Ribonuclease J, C-terminal", "go_ids": [], "go_terms": [], "name": "RNase_J_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041637": {"description": "Caprin-1 dimerization domain", "go_ids": [], "go_terms": [], "name": "Caprin-1_dimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041638": {"description": "Bacterial archaeo-eukaryotic release factor family 11", "go_ids": [], "go_terms": [], "name": "BaeRF_family11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041639": {"description": "Large polyvalent protein-associated domain 39", "go_ids": [], "go_terms": [], "name": "LPD39", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041640": {"description": "Tyrosinase, C-terminal", "go_ids": [], "go_terms": [], "name": "Tyrosinase_C", "pathway_ids": ["PWY-7913", "PWY-7917", "PWY-6481"], "pathways": ["PWY-7913:t:firefly bioluminescence", "PWY-7917:t:pheomelanin biosynthesis", "PWY-6481:t:L-dopa and L-dopachrome biosynthesis"], "type": "Domain"}, "IPR041641": {"description": "CALCOCO1/2, zinc finger UBZ1-type", "go_ids": [], "go_terms": [], "name": "CALCOCO1/2_Zn_UBZ1", "pathway_ids": ["R-HSA-933541", "R-HSA-5357905", "R-BTA-936440", "R-HSA-9013973", "R-RNO-936440", "R-MMU-5357905", "R-HSA-9828211", "R-MMU-936440", "R-HSA-9824878", "R-RNO-5357905", "R-HSA-936440", "R-BTA-5357905", "R-HSA-936964", "R-MMU-9824878", "R-MMU-936964"], "pathways": ["R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "type": "Domain"}, "IPR041642": {"description": "HTH-type transcriptional repressor KstR, C-terminal", "go_ids": [], "go_terms": [], "name": "KstR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041643": {"description": "ZIC protein, zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_ZIC", "pathway_ids": ["R-HSA-9856649", "R-HSA-452723", "R-HSA-2892247", "R-HSA-9834899", "R-HSA-9823739"], "pathways": ["R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-9823739:r:Formation of the anterior neural plate"], "type": "Domain"}, "IPR041644": {"description": "GNAT-like C-terminal domain", "go_ids": [], "go_terms": [], "name": "GNAT_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041645": {"description": "ADAMTS, cysteine-rich domain 2", "go_ids": [], "go_terms": [], "name": "ADAMTS_CR_2", "pathway_ids": ["PWY-8119", "R-HSA-1474228", "R-HSA-5083635", "R-RNO-1474228", "R-BTA-5173214", "R-HSA-9845619", "R-HSA-9845621", "R-HSA-1650814", "R-RNO-5173214", "R-HSA-75892", "R-HSA-5173214", "R-MMU-1650814", "R-MMU-5173214", "R-CEL-5173214", "R-BTA-1650814", "R-MMU-1474228"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-CEL-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR041646": {"description": "IcaR, C-terminal", "go_ids": [], "go_terms": [], "name": "IcaR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041647": {"description": "Inward rectifier potassium channel, C-terminal", "go_ids": [], "go_terms": [], "name": "IRK_C", "pathway_ids": ["R-HSA-1296053", "R-SSC-1296053", "R-RNO-1296053", "R-MMU-422356", "R-MMU-1296025", "R-RNO-382556", "R-HSA-5576886", "R-GGA-5576886", "R-MMU-1296067", "R-CEL-1296067", "R-MMU-1296053", "R-CFA-997272", "R-BTA-1296041", "R-RNO-1296025", "R-HSA-9729555", "R-GGA-997272", "R-CFA-1296053", "R-HSA-1296041", "R-HSA-5578775", "R-CEL-5576886", "R-BTA-997272", "R-HSA-1296025", "R-SSC-997272", "R-HSA-997272", "R-HSA-1296067", "R-MMU-382556", "R-SSC-5576886", "R-RNO-997272", "R-RNO-5578775", "R-HSA-382556", "R-MMU-5578775", "R-MMU-5576886", "R-CFA-5576886", "R-MMU-1296041", "R-RNO-5576886", "R-RNO-1296041", "R-HSA-5678420", "R-BTA-1296053", "R-RNO-422356", "R-CEL-1296053", "R-GGA-1296053", "R-RNO-1296067", "R-MMU-997272", "R-BTA-5576886", "R-SSC-1296041", "R-GGA-1296041", "R-CFA-1296041", "R-CEL-997272", "R-CEL-1296041", "R-HSA-5683177", "R-HSA-422356"], "pathways": ["R-HSA-1296053:r:Classical Kir channels", "R-SSC-1296053:r:Classical Kir channels", "R-RNO-1296053:r:Classical Kir channels", "R-MMU-422356:r:Regulation of insulin secretion", "R-MMU-1296025:r:ATP sensitive Potassium channels", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5576886:r:Phase 4 - resting membrane potential", "R-GGA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296067:r:Potassium transport channels", "R-CEL-1296067:r:Potassium transport channels", "R-MMU-1296053:r:Classical Kir channels", "R-CFA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-1296025:r:ATP sensitive Potassium channels", "R-HSA-9729555:r:Sensory perception of sour taste", "R-GGA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CFA-1296053:r:Classical Kir channels", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5578775:r:Ion homeostasis", "R-CEL-5576886:r:Phase 4 - resting membrane potential", "R-BTA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296025:r:ATP sensitive Potassium channels", "R-SSC-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-1296067:r:Potassium transport channels", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-SSC-5576886:r:Phase 4 - resting membrane potential", "R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-5576886:r:Phase 4 - resting membrane potential", "R-CFA-5576886:r:Phase 4 - resting membrane potential", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-5576886:r:Phase 4 - resting membrane potential", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5678420:r:Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome", "R-BTA-1296053:r:Classical Kir channels", "R-RNO-422356:r:Regulation of insulin secretion", "R-CEL-1296053:r:Classical Kir channels", "R-GGA-1296053:r:Classical Kir channels", "R-RNO-1296067:r:Potassium transport channels", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-BTA-5576886:r:Phase 4 - resting membrane potential", "R-SSC-1296041:r:Activation of G protein gated Potassium channels", "R-GGA-1296041:r:Activation of G protein gated Potassium channels", "R-CFA-1296041:r:Activation of G protein gated Potassium channels", "R-CEL-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-CEL-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-5683177:r:Defective ABCC8 can cause hypo- and hyper-glycemias", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Domain"}, "IPR041648": {"description": "Rank, cysteine-rich repeat domain 2", "go_ids": [], "go_terms": [], "name": "RANK_CRD_2", "pathway_ids": ["R-HSA-5668541", "R-MMU-5668541", "R-MMU-5676594", "R-HSA-5676594"], "pathways": ["R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "type": "Domain"}, "IPR041649": {"description": "Anti-sigma factor NepR", "go_ids": [], "go_terms": [], "name": "NepR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041650": {"description": "Swt1-like HEPN", "go_ids": [], "go_terms": [], "name": "HEPN_Swt1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041651": {"description": "Domain of unknown function DUF5610", "go_ids": [], "go_terms": [], "name": "DUF5610", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041652": {"description": "Domain of unknown function DUF5616", "go_ids": [], "go_terms": [], "name": "DUF5616", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041653": {"description": "Importin repeat 4", "go_ids": [], "go_terms": [], "name": "Importin_rep_4", "pathway_ids": ["R-HSA-192905"], "pathways": ["R-HSA-192905:r:vRNP Assembly"], "type": "Repeat"}, "IPR041654": {"description": "Styrene monooxygenase StyA, putative substrate binding domain", "go_ids": [], "go_terms": [], "name": "StyA_sbd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041655": {"description": "Domain of unknown function DUF5607", "go_ids": [], "go_terms": [], "name": "DUF5607", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041656": {"description": "Tetratrico peptide repeat, group 5", "go_ids": [], "go_terms": [], "name": "TPR_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041657": {"description": "Helix-turn-helix domain, group 17", "go_ids": [], "go_terms": [], "name": "HTH_17", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041658": {"description": "Dynein heavy chain, AAA lid domain", "go_ids": [], "go_terms": [], "name": "AAA_lid_11", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR041661": {"description": "ZN622/Rei1/Reh1, zinc finger C2H2-type", "go_ids": [], "go_terms": [], "name": "ZN622/Rei1/Reh1_Znf-C2H2", "pathway_ids": ["R-DME-390193"], "pathways": ["R-DME-390193:r:Transcriptional activation by YKI"], "type": "Domain"}, "IPR041662": {"description": "SusD-like 2", "go_ids": [], "go_terms": [], "name": "SusD-like_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041663": {"description": "DisA/LigA, helix-hairpin-helix motif", "go_ids": [], "go_terms": [], "name": "DisA/LigA_HHH", "pathway_ids": ["R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-BTA-9833482", "R-BTA-6783310", "R-MMU-6783310"], "pathways": ["R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-BTA-9833482:r:PKR-mediated signaling", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR041664": {"description": "Orc1-like, AAA ATPase domain", "go_ids": [], "go_terms": [], "name": "AAA_16", "pathway_ids": ["R-HSA-68949", "R-SPO-68616", "R-BTA-68616", "R-HSA-69205", "R-HSA-113507", "R-BTA-68949", "R-MMU-68949", "R-BTA-68962", "R-BTA-176187", "R-HSA-68616", "R-DME-68962", "R-HSA-68962", "R-BTA-68689", "R-HSA-176187", "R-DME-68949", "R-DME-176187", "R-HSA-68867", "R-SPO-176187", "R-MMU-68962", "R-HSA-68689", "R-DME-68616", "R-DME-68689", "R-HSA-1362277", "R-SPO-68689", "R-HSA-69017", "R-MMU-176187", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949"], "pathways": ["R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-BTA-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin"], "type": "Domain"}, "IPR041667": {"description": "Cupin-like domain 8", "go_ids": [], "go_terms": [], "name": "Cupin_8", "pathway_ids": ["R-RNO-9629569", "R-MMU-1234174", "R-MMU-9629569", "R-MMU-3214842", "R-HSA-1234174", "R-DDI-9629569", "R-HSA-6782861", "R-DRE-9629569", "R-DRE-1234174", "R-HSA-3214842", "R-DME-9629569", "R-XTR-9629569", "R-CEL-3214842", "R-BTA-9629569", "R-HSA-9629569"], "pathways": ["R-RNO-9629569:r:Protein hydroxylation", "R-MMU-1234174:r:Cellular response to hypoxia", "R-MMU-9629569:r:Protein hydroxylation", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-1234174:r:Cellular response to hypoxia", "R-DDI-9629569:r:Protein hydroxylation", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)", "R-DRE-9629569:r:Protein hydroxylation", "R-DRE-1234174:r:Cellular response to hypoxia", "R-HSA-3214842:r:HDMs demethylate histones", "R-DME-9629569:r:Protein hydroxylation", "R-XTR-9629569:r:Protein hydroxylation", "R-CEL-3214842:r:HDMs demethylate histones", "R-BTA-9629569:r:Protein hydroxylation", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Domain"}, "IPR041668": {"description": "RBP-2-like, helical domain", "go_ids": [], "go_terms": [], "name": "RBP-2-like_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041669": {"description": "Tetracyclin repressor SlmA-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_C_15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041670": {"description": "Zinc knuckle", "go_ids": [], "go_terms": [], "name": "Znf-CCHC_6", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DME-76042", "R-MMU-6804756", "R-DME-73779", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-HSA-73776", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-CEL-73776", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-DME-674695", "R-MMU-674695", "R-SCE-76042", "R-DME-6804756", "R-CEL-674695", "R-HSA-167161", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-76042", "R-HSA-674695", "R-SPO-73776", "R-CEL-76042", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR041671": {"description": "Csm1 N-terminal domain", "go_ids": [], "go_terms": [], "name": "Csm1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041672": {"description": "Bap31/Bap29 cytoplasmic coiled-coil domain", "go_ids": [], "go_terms": [], "name": "Bap31/Bap29_C", "pathway_ids": ["R-HSA-983170", "R-HSA-8980692", "R-MMU-983170", "R-MMU-111465", "R-HSA-111465", "R-MMU-8980692", "R-HSA-9833110", "R-HSA-75153", "R-DDI-75153", "R-MMU-75153"], "pathways": ["R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-75153:r:Apoptotic execution phase", "R-DDI-75153:r:Apoptotic execution phase", "R-MMU-75153:r:Apoptotic execution phase"], "type": "Domain"}, "IPR041673": {"description": "Tetracyclin repressor-like, C-terminal domain 23", "go_ids": [], "go_terms": [], "name": "TetR_C_23", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041674": {"description": "Tetracyclin repressor SCO1712-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_C_22", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041675": {"description": "Pleckstrin homology domain 5", "go_ids": [], "go_terms": [], "name": "PH_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041677": {"description": "DNA2/NAM7 helicase, helicase domain", "go_ids": ["GO:0004386"], "go_terms": ["GO:0004386:helicase activity:F"], "name": "DNA2/NAM7_AAA_11", "pathway_ids": ["R-HSA-1989781", "R-HSA-2151201", "R-RNO-174437", "R-BTA-5685938", "R-CEL-975957", "R-HSA-5693616", "R-HSA-9022692", "R-HSA-2559580", "R-HSA-8936459", "R-HSA-8948700", "R-MMU-6804756", "R-SPO-975957", "R-MMU-5693616", "R-MMU-5685938", "R-HSA-1368108", "R-HSA-6781823", "R-HSA-9764562", "R-MMU-69473", "R-HSA-975956", "R-CEL-975956", "R-HSA-9709570", "R-HSA-5693607", "R-BTA-6804756", "R-HSA-9933387", "R-BTA-5693616", "R-MMU-174437", "R-HSA-9707564", "R-HSA-9759811", "R-BTA-5693607", "R-MMU-5693568", "R-DME-400206", "R-HSA-9824594", "R-HSA-9018519", "R-SPO-69166", "R-HSA-5601884", "R-SPO-975956", "R-RNO-5693579", "R-BTA-5693568", "R-SCE-975956", "R-HSA-69473", "R-MMU-72163", "R-RNO-5693607", "R-HSA-8934593", "R-RNO-69473", "R-HSA-72163", "R-HSA-9768778", "R-HSA-6804756", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-400206", "R-MMU-6782210", "R-RNO-5693616", "R-HSA-5693554", "R-HSA-8986944", "R-MMU-400206", "R-HSA-8853884", "R-DDI-975956", "R-BTA-69473", "R-HSA-6781827", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-9704646", "R-HSA-2559585", "R-BTA-174437", "R-HSA-5628897", "R-HSA-1912408", "R-RNO-69166", "R-MMU-6781823", "R-HSA-174437", "R-SCE-975957", "R-BTA-69166", "R-RNO-5685938", "R-HSA-6782210", "R-RNO-6804756", "R-BTA-5693579", "R-HSA-4086398", "R-MMU-5693579", "R-HSA-9029569", "R-HSA-9918481", "R-HSA-5693568", "R-HSA-5685938", "R-HSA-9931509", "R-MMU-5693607", "R-HSA-9701192", "R-MMU-975956", "R-DRE-975956", "R-DME-975956", "R-HSA-9839394", "R-DME-9707564", "R-HSA-8943723", "R-MMU-975957", "R-HSA-381340", "R-HSA-9707616", "R-HSA-6782135", "R-DRE-975957", "R-HSA-9709603", "R-MMU-5685942", "R-HSA-69166", "R-RNO-5685942", "R-HSA-9725371", "R-HSA-975957", "R-HSA-5687128", "R-MMU-69166", "R-BTA-5685942", "R-HSA-9909620", "R-DDI-975957", "R-HSA-5693579", "R-DME-975957", "R-HSA-2426168", "R-MMU-9707564"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9839394:r:TGFBR3 expression", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR041678": {"description": "Tetracyclin repressor-like, C-terminal domain 16", "go_ids": [], "go_terms": [], "name": "TetR_C_16", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041679": {"description": "DNA2/NAM7 helicase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "DNA2/NAM7-like_C", "pathway_ids": ["R-HSA-1989781", "R-HSA-2151201", "R-RNO-174437", "R-BTA-5685938", "R-CEL-975957", "R-HSA-5693616", "R-HSA-9022692", "R-HSA-2559580", "R-HSA-8936459", "R-HSA-8948700", "R-MMU-6804756", "R-SPO-975957", "R-MMU-5693616", "R-MMU-5685938", "R-HSA-1368108", "R-HSA-6781823", "R-HSA-9764562", "R-MMU-69473", "R-HSA-975956", "R-CEL-975956", "R-HSA-9709570", "R-HSA-5693607", "R-BTA-6804756", "R-HSA-9933387", "R-BTA-5693616", "R-MMU-174437", "R-HSA-9707564", "R-HSA-9759811", "R-BTA-5693607", "R-MMU-5693568", "R-DME-400206", "R-HSA-9824594", "R-HSA-9018519", "R-SPO-69166", "R-HSA-5601884", "R-HSA-9694786", "R-SPO-975956", "R-HSA-9694686", "R-RNO-5693579", "R-BTA-5693568", "R-SCE-975956", "R-HSA-69473", "R-HSA-9683439", "R-MMU-72163", "R-RNO-5693607", "R-HSA-9735869", "R-HSA-8934593", "R-RNO-69473", "R-HSA-72163", "R-HSA-9768778", "R-HSA-6804756", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-400206", "R-MMU-6782210", "R-RNO-5693616", "R-HSA-5693554", "R-HSA-8986944", "R-HSA-9679504", "R-MMU-400206", "R-HSA-8853884", "R-DDI-975956", "R-BTA-69473", "R-HSA-191859", "R-HSA-9705671", "R-HSA-6781827", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-9704646", "R-HSA-2559585", "R-HSA-9682706", "R-BTA-174437", "R-HSA-5628897", "R-HSA-1912408", "R-HSA-918233", "R-RNO-69166", "R-HSA-174437", "R-MMU-6781823", "R-SCE-975957", "R-BTA-69166", "R-RNO-5685938", "R-HSA-6782210", "R-RNO-6804756", "R-BTA-5693579", "R-HSA-4086398", "R-HSA-9682708", "R-MMU-5693579", "R-HSA-9029569", "R-HSA-9918481", "R-HSA-5693568", "R-HSA-5685938", "R-HSA-9931509", "R-MMU-5693607", "R-HSA-9701192", "R-MMU-975956", "R-HSA-9694676", "R-DRE-975956", "R-DME-975957", "R-DME-975956", "R-HSA-9684325", "R-HSA-9839394", "R-DME-9707564", "R-HSA-8943723", "R-MMU-975957", "R-HSA-381340", "R-HSA-9707616", "R-HSA-6782135", "R-DRE-975957", "R-HSA-9709603", "R-MMU-5685942", "R-HSA-69166", "R-HSA-9754678", "R-HSA-9694271", "R-RNO-5685942", "R-HSA-9725371", "R-HSA-975957", "R-HSA-5687128", "R-SPO-6782210", "R-HSA-9692916", "R-MMU-69166", "R-BTA-5685942", "R-HSA-9909620", "R-DDI-975957", "R-SPO-6782135", "R-HSA-5693579", "R-SPO-72163", "R-HSA-9694301", "R-HSA-2426168", "R-MMU-9707564"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9839394:r:TGFBR3 expression", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR041680": {"description": "Pleckstrin homology domain 8", "go_ids": [], "go_terms": [], "name": "PH_8", "pathway_ids": ["R-HSA-192105", "R-MMU-1482801", "R-SCE-192105", "R-SPO-192105", "R-HSA-1482801", "R-MMU-192105"], "pathways": ["R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-SCE-192105:r:Synthesis of bile acids and bile salts", "R-SPO-192105:r:Synthesis of bile acids and bile salts", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-MMU-192105:r:Synthesis of bile acids and bile salts"], "type": "Domain"}, "IPR041681": {"description": "Pleckstrin homology domain 9", "go_ids": [], "go_terms": [], "name": "PH_9", "pathway_ids": ["R-DME-445095", "R-HSA-2132295", "R-HSA-9013420", "R-DME-5673001", "R-RNO-2132295", "R-RNO-445095", "R-HSA-445095", "R-DME-375165", "R-RNO-6807878", "R-MMU-8980692", "R-HSA-9662361", "R-HSA-6807878", "R-MMU-9013424", "R-DME-9013424", "R-HSA-9013424", "R-MMU-6807878", "R-HSA-375165", "R-HSA-5673001", "R-HSA-9703465", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013420", "R-HSA-9662360", "R-MMU-445095", "R-MMU-9013149", "R-RNO-375165", "R-DME-6807878", "R-RNO-5673001", "R-MMU-5673001", "R-DME-9013420", "R-MMU-375165", "R-HSA-373753"], "pathways": ["R-DME-445095:r:Interaction between L1 and Ankyrins", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-445095:r:Interaction between L1 and Ankyrins", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-DME-375165:r:NCAM signaling for neurite out-growth", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-HSA-373753:r:Nephrin family interactions"], "type": "Domain"}, "IPR041682": {"description": "AAA domain, group 14", "go_ids": [], "go_terms": [], "name": "AAA_14", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041684": {"description": "PHD/FYVE-zinc-finger like domain", "go_ids": [], "go_terms": [], "name": "Znf-PHD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041685": {"description": "Endonuclease GajA/Old nuclease/RecF-like, AAA domain", "go_ids": [], "go_terms": [], "name": "AAA_GajA/Old/RecF-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041686": {"description": "Zinc-finger CCCH domain", "go_ids": [], "go_terms": [], "name": "Znf-CCCH_3", "pathway_ids": ["R-HSA-9770562", "R-GGA-73856", "R-XTR-9770562", "R-HSA-6784531", "R-BTA-73856", "R-HSA-73856", "R-RNO-77595", "R-HSA-168315", "R-HSA-72187", "R-MMU-73856", "R-MMU-159236", "R-HSA-159231", "R-RNO-73856", "R-HSA-77595", "R-MMU-72187", "R-RNO-159231", "R-XTR-77595", "R-RNO-9770562", "R-BTA-9770562", "R-BTA-159231", "R-HSA-159236", "R-HSA-9918481", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-GGA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-9770562:r:mRNA Polyadenylation", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-168315:r:Inhibition of Host mRNA Processing and RNA Silencing", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-XTR-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR041687": {"description": "IprA, winged helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "HTH_46", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041688": {"description": "Orotate phosphoribosyltransferase-like", "go_ids": [], "go_terms": [], "name": "PRTase_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041689": {"description": "Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "GBR2_CC", "pathway_ids": ["R-RNO-997272", "R-HSA-418594", "R-MMU-977444", "R-RNO-977444", "R-MMU-420499", "R-HSA-420499", "R-HSA-977444", "R-HSA-1296041", "R-RNO-420499", "R-MMU-997272", "R-RNO-1296041", "R-HSA-997272", "R-MMU-418594", "R-MMU-1296041", "R-RNO-418594"], "pathways": ["R-RNO-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-977444:r:GABA B receptor activation", "R-RNO-977444:r:GABA B receptor activation", "R-MMU-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-977444:r:GABA B receptor activation", "R-HSA-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-420499:r:Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-MMU-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-RNO-1296041:r:Activation of G protein gated Potassium channels", "R-HSA-997272:r:Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-MMU-418594:r:G alpha (i) signalling events", "R-MMU-1296041:r:Activation of G protein gated Potassium channels", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Domain"}, "IPR041690": {"description": "Cadherin-like domain", "go_ids": [], "go_terms": [], "name": "Cadherin_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041691": {"description": "Atg6/beclin, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "Atg6/beclin_CC", "pathway_ids": ["R-DRE-5689880", "R-HSA-9694676", "R-DDI-1632852", "R-HSA-9705671", "R-BTA-5689880", "R-HSA-5689880", "R-MMU-1632852", "R-CEL-1632852", "R-RNO-1169408", "R-HSA-1169408", "R-MMU-1169408", "R-BTA-1632852", "R-RNO-5689880", "R-CEL-5689880", "R-MMU-5689880", "R-SCE-1632852", "R-HSA-983170", "R-CEL-1169408", "R-RNO-1632852", "R-XTR-1632852", "R-DDI-5689880", "R-HSA-1632852", "R-DME-1632852", "R-HSA-9833110", "R-HSA-9920951", "R-SPO-1632852", "R-BTA-1169408", "R-HSA-9679504", "R-DME-5689880", "R-DDI-1169408"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DDI-1632852:r:Macroautophagy", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-BTA-1632852:r:Macroautophagy", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-1632852:r:Macroautophagy", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-SPO-1632852:r:Macroautophagy", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DME-5689880:r:Ub-specific processing proteases", "R-DDI-1169408:r:ISG15 antiviral mechanism"], "type": "Domain"}, "IPR041692": {"description": "HHH domain 9", "go_ids": [], "go_terms": [], "name": "HHH_9", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Domain"}, "IPR041693": {"description": "Glycosyl-transferase family 4_5", "go_ids": [], "go_terms": [], "name": "Glyco_trans_4_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041694": {"description": "Oxidoreductase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ADH_N_2", "pathway_ids": ["R-HSA-2162123", "R-HSA-2142700", "R-HSA-2142691"], "pathways": ["R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "type": "Domain"}, "IPR041695": {"description": "Glutathione S-transferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GST_C_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041696": {"description": "Bacteroidetes PKD-like domain", "go_ids": [], "go_terms": [], "name": "PKD_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041697": {"description": "Zinc-finger C2H2-type 11", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041698": {"description": "Methyltransferase domain 25", "go_ids": [], "go_terms": [], "name": "Methyltransf_25", "pathway_ids": ["R-MMU-8936459", "R-XTR-8936459", "R-XTR-3214858", "R-XTR-9018519", "R-RNO-3214858", "R-HSA-8936459", "R-SPO-9018519", "R-DDI-3214858", "R-RNO-9009391", "R-RNO-389661", "R-HSA-9925561", "R-XTR-9009391", "R-MMU-9009391", "R-MMU-375276", "R-HSA-2408508", "R-HSA-389661", "R-RNO-9018519", "R-DDI-8876725", "R-RNO-8936459", "R-MMU-3214858", "R-BTA-3214858", "R-HSA-9694631", "R-HSA-3214858", "R-MMU-9018519", "R-HSA-9009391", "R-SPO-8876725", "R-HSA-6804114", "R-DDI-9018519", "R-BTA-8936459", "R-SPO-3214858", "R-HSA-9018519"], "pathways": ["R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-XTR-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-XTR-3214858:r:RMTs methylate histone arginines", "R-XTR-9018519:r:Estrogen-dependent gene expression", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-389661:r:Glyoxylate metabolism and glycine degradation", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-XTR-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-HSA-389661:r:Glyoxylate metabolism and glycine degradation", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-DDI-8876725:r:Protein methylation", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-8876725:r:Protein methylation", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-BTA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR041699": {"description": "Lon protease, AAA domain", "go_ids": [], "go_terms": [], "name": "AAA_32", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041700": {"description": "Outer membrane protein beta-barrel domain 3", "go_ids": [], "go_terms": [], "name": "OMP_b-brl_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041708": {"description": "Pseudouridine synthase PUS1/ PUS2-like", "go_ids": ["GO:0009982", "GO:0031119"], "go_terms": ["GO:0009982:pseudouridine synthase activity:F", "GO:0031119:tRNA pseudouridine synthesis:P"], "name": "PUS1/PUS2-like", "pathway_ids": ["PWY-7599", "PWY-7419", "PWY-8341", "PWY-7251", "R-HSA-6782315", "R-HSA-6787450"], "pathways": ["PWY-7599:t:anditomin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-8341:t:N1-methyl-N3-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis", "PWY-7251:t:pentacyclic triterpene biosynthesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Family"}, "IPR041715": {"description": "Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain", "go_ids": [], "go_terms": [], "name": "HisRS-like_core", "pathway_ids": ["R-HSA-379716", "R-HSA-379726", "R-HSA-9633012"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR041720": {"description": "Aldolase FbaB-like, archaeal-type", "go_ids": ["GO:0004332"], "go_terms": ["GO:0004332:fructose-bisphosphate aldolase activity:F"], "name": "FbaB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041752": {"description": "Cytochrome c oxidase assembly factor 3, mitochondrial", "go_ids": ["GO:0033617"], "go_terms": ["GO:0033617:mitochondrial respiratory chain complex IV assembly:P"], "name": "Coa3", "pathway_ids": ["R-HSA-9864848", "R-MMU-9864848", "R-BTA-9864848", "R-DME-9864848", "R-DRE-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-9864848:r:Complex IV assembly", "R-DME-9864848:r:Complex IV assembly", "R-DRE-9864848:r:Complex IV assembly"], "type": "Family"}, "IPR041755": {"description": "Archaeal Hef helicase/nuclease, insert domain", "go_ids": [], "go_terms": [], "name": "Hef_ID", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR041768": {"description": "Tyrosine-protein phosphatase", "go_ids": [], "go_terms": [], "name": "RLPH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041793": {"description": "Myosin VII, FERM domain C-lobe, repeat 1", "go_ids": [], "go_terms": [], "name": "MyoVII_FERM_C1", "pathway_ids": ["R-MMU-2453902", "R-CEL-2453902", "R-HSA-9662360", "R-DME-2453902", "R-HSA-9662361", "R-HSA-2453902"], "pathways": ["R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Domain"}, "IPR041814": {"description": "Type III secretion system virulence factor YopR, core domain", "go_ids": [], "go_terms": [], "name": "YopR_core", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041848": {"description": "Guanine nucleotide-binding protein subunit gamma, fungal", "go_ids": ["GO:0031681", "GO:0007186"], "go_terms": ["GO:0031681:G-protein beta-subunit binding:F", "GO:0007186:G protein-coupled receptor signaling pathway:P"], "name": "Ste18_fungal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR041851": {"description": "RecBCD enzyme subunit RecD, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "RecD_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041854": {"description": "BFD-like [2Fe-2S]-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "BFD-like_2Fe2S-bd_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041855": {"description": "Lysin B, C-terminal linker domain", "go_ids": [], "go_terms": [], "name": "Lysin_B_C_ter", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041856": {"description": "Glutamine-dependent NAD+ synthetase, C-terminal", "go_ids": [], "go_terms": [], "name": "NAD+_synth_C", "pathway_ids": ["PWY-8277", "PWY-5653", "PWY-5381", "PWY-8352", "PWY-7761"], "pathways": ["PWY-8277:t:NAD de novo biosynthesis IV (anaerobic)", "PWY-5653:t:NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde", "PWY-5381:t:NAD salvage (plants)", "PWY-8352:t:NAD de novo biosynthesis III", "PWY-7761:t:NAD salvage pathway II (PNC IV cycle)"], "type": "Homologous_superfamily"}, "IPR041872": {"description": "Methionyl-tRNA synthetase, anticodon-binding domain", "go_ids": [], "go_terms": [], "name": "Anticodon_Met", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-HSA-9856649", "R-DDI-9856649", "R-HSA-2408522", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR041881": {"description": "Coenzyme PQQ synthesis protein D superfamily", "go_ids": [], "go_terms": [], "name": "PqqD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041883": {"description": "PilM protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PilM_N-ter", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041884": {"description": "PilM protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PilM_C-ter", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041885": {"description": "MAN1, winged-helix domain", "go_ids": [], "go_terms": [], "name": "MAN1_winged_helix_dom", "pathway_ids": ["R-HSA-9013405", "R-HSA-9696270", "R-HSA-2995383", "R-HSA-9668328", "R-HSA-9696264", "R-HSA-9013404", "R-HSA-9013423", "R-HSA-9013149", "R-SPO-9668328", "R-HSA-4419969", "R-HSA-2980766", "R-SCE-9668328", "R-HSA-9013408", "R-HSA-9696273"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-SCE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR041893": {"description": "Antirestriction protein ArdA, domain 3", "go_ids": [], "go_terms": [], "name": "ArdA_dom3", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041895": {"description": "Antirestriction protein ArdA, domain 1", "go_ids": [], "go_terms": [], "name": "ArdA_dom1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041896": {"description": "Antirestriction protein ArdA, domain 2", "go_ids": [], "go_terms": [], "name": "ArdA_dom2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041898": {"description": "MAGE homology domain, winged helix WH1 motif", "go_ids": [], "go_terms": [], "name": "MAGE_WH1", "pathway_ids": ["R-SCE-3108214", "R-HSA-114608", "R-HSA-193648", "R-SPO-3108214", "R-RNO-9768919", "R-HSA-3108214", "R-MMU-9768919", "R-HSA-418889", "R-SCE-114608", "R-MMU-3108214", "R-HSA-6785807", "R-SPO-114608", "R-HSA-9768919"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-SCE-114608:r:Platelet degranulation", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SPO-114608:r:Platelet degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Homologous_superfamily"}, "IPR041899": {"description": "MAGE homology domain, winged helix WH2 motif", "go_ids": [], "go_terms": [], "name": "MAGE_WH2", "pathway_ids": ["R-SCE-3108214", "R-HSA-114608", "R-HSA-193648", "R-SPO-3108214", "R-RNO-9768919", "R-HSA-3108214", "R-MMU-9768919", "R-HSA-418889", "R-SCE-114608", "R-MMU-3108214", "R-HSA-6785807", "R-SPO-114608", "R-HSA-9768919"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-193648:r:NRAGE signals death through JNK", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-SCE-114608:r:Platelet degranulation", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SPO-114608:r:Platelet degranulation", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Homologous_superfamily"}, "IPR041902": {"description": "CtsR, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CtsR_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041908": {"description": "CtsR, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CtsR_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041909": {"description": "Sbi, C3 binding domain IV", "go_ids": [], "go_terms": [], "name": "Sbi_C3_db_domIV", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041910": {"description": "Alpha-helical PorB/PorC", "go_ids": [], "go_terms": [], "name": "Alpha_h_PorB/PorC", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041913": {"description": "DNA polymerase delta subunit 3 superfamily", "go_ids": [], "go_terms": [], "name": "POLD3_sf", "pathway_ids": ["R-BTA-5358606", "R-BTA-174411", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-174414", "R-SPO-5656169", "R-HSA-5696397", "R-HSA-5358606", "R-MMU-174417", "R-BTA-174437", "R-BTA-174417", "R-MMU-110314", "R-HSA-174417", "R-MMU-174414", "R-SPO-69091", "R-BTA-5651801", "R-BTA-69166", "R-MMU-174437", "R-BTA-5696397", "R-HSA-6782210", "R-BTA-5656169", "R-BTA-110314", "R-BTA-5696400", "R-HSA-5656169", "R-BTA-69183", "R-MMU-5358606", "R-SPO-69166", "R-MMU-5696400", "R-MMU-5358565", "R-SPO-5696397", "R-MMU-5651801", "R-BTA-6782135", "R-SPO-69183", "R-BTA-69091", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-174411", "R-HSA-5651801", "R-HSA-69166", "R-MMU-69183", "R-SPO-5696400", "R-BTA-5358565", "R-SPO-110314", "R-SPO-6782210", "R-HSA-69183", "R-BTA-5685942", "R-MMU-69166", "R-HSA-5696400", "R-BTA-6782210", "R-HSA-5358565", "R-BTA-174414", "R-SPO-6782135", "R-HSA-69091", "R-HSA-174437", "R-MMU-6782210", "R-MMU-5696397", "R-MMU-174411", "R-MMU-69091", "R-GGA-353416", "R-HSA-110314", "R-SPO-5651801"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-69091:r:Polymerase switching", "R-BTA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-BTA-69183:r:Processive synthesis on the lagging strand", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-6782135:r:Dual incision in TC-NER", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-BTA-69091:r:Polymerase switching", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-BTA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-69091:r:Polymerase switching", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-GGA-353416:r:Resolution of Abasic Sites (AP sites)", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Homologous_superfamily"}, "IPR041916": {"description": "Anti-sigma factor, zinc-finger domain superfamily", "go_ids": [], "go_terms": [], "name": "Anti_sigma_zinc_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041919": {"description": "Plasmid replication protein, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Plasmid_rep_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041920": {"description": "ROS/MUCR transcriptional regulator superfamily", "go_ids": [], "go_terms": [], "name": "ROS/MUCR_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041921": {"description": "NADH-quinone oxidoreductase subunit E, N-terminal", "go_ids": [], "go_terms": [], "name": "NuoE_N", "pathway_ids": ["R-RNO-611105", "R-HSA-611105", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198", "R-MMU-611105", "R-BTA-6799198", "R-DDI-6799198", "R-BTA-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-BTA-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-BTA-611105:r:Respiratory electron transport"], "type": "Homologous_superfamily"}, "IPR041931": {"description": "Bacterial DNA polymerase III alpha subunit, thumb domain", "go_ids": [], "go_terms": [], "name": "DNA_pol3_alpha_thumb_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041934": {"description": "NAD glycohydrolase, helical linker domain", "go_ids": [], "go_terms": [], "name": "NAD_glyco_helical_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR041935": {"description": "HetR, flap domain", "go_ids": [], "go_terms": [], "name": "HetR_flap", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR041936": {"description": "HetR, N-terminal DNA-binding domain", "go_ids": [], "go_terms": [], "name": "HetR_DNA-bd_N", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR041938": {"description": "Histone-lysine N-methyltransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Hist-Lys_N-MTase_N", "pathway_ids": ["R-HSA-3214841", "R-DME-3214841", "R-MMU-3214841", "R-DRE-3214841", "R-SPO-3214841", "R-RNO-3214841"], "pathways": ["R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DME-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-SPO-3214841:r:PKMTs methylate histone lysines", "R-RNO-3214841:r:PKMTs methylate histone lysines"], "type": "Homologous_superfamily"}, "IPR041948": {"description": "RNA ligase 1/2, C-terminal domain 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"R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-72086:r:mRNA Capping", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-GGA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", 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"R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Homologous_superfamily"}, "IPR042032": {"description": "Viral RNA-directed RNA polymerase, 4-helical domain", "go_ids": [], "go_terms": [], "name": "RNA-dir_pol_4-hel_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042033": {"description": "Big defensin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Defensin_big_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042034": {"description": "Host-nuclease inhibitor Gam superfamily", "go_ids": [], "go_terms": [], "name": "Gam_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042035": {"description": "DEAH helicase, winged-helix domain", "go_ids": [], "go_terms": [], "name": "DEAH_win-hel_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042036": {"description": "Ribosomal RNA-processing protein 8, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RRP8_N", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-RNO-427359", "R-DME-427359", "R-HSA-427359"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-RNO-427359:r:SIRT1 negatively regulates rRNA expression", "R-DME-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression"], "type": "Homologous_superfamily"}, "IPR042037": {"description": "MukE, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MukE_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042038": {"description": "MukE, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MukE_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042040": {"description": "Protein transport protein Tip20, domain E", "go_ids": [], "go_terms": [], "name": "Tip20p_domE", "pathway_ids": ["R-SCE-6811434"], "pathways": ["R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR042041": {"description": "Protein transport protein Tip20, domain A", "go_ids": [], "go_terms": [], "name": "Tip20p_domA", "pathway_ids": ["R-SCE-6811434"], "pathways": ["R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR042042": {"description": "Protein transport protein Tip20, domain B", "go_ids": [], "go_terms": [], "name": "Tip20p_domB", "pathway_ids": ["R-SCE-6811434"], "pathways": ["R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR042043": {"description": "Protein transport protein Tip20, domain C", "go_ids": [], "go_terms": [], "name": "Tip20p_domC", "pathway_ids": ["R-SCE-6811434"], "pathways": ["R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR042044": {"description": "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2", "go_ids": [], "go_terms": [], "name": "EXOC6PINT-1/Sec15/Tip20_C_dom2", "pathway_ids": ["R-DME-6811434", "R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-HSA-6811434", "R-MMU-5620916", "R-DME-5620916", "R-SCE-6811434", "R-DME-264876", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-SPO-6811434", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-MMU-6811434"], "pathways": ["R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-264876:r:Insulin processing", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR042045": {"description": "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1", "go_ids": [], "go_terms": [], "name": "EXOC6/Sec15_C_dom1", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Homologous_superfamily"}, "IPR042046": {"description": "Lepidopteran low molecular weight lipoprotein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Lipoprotein_11_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042047": {"description": "Cell wall hydrolase SleB, domain 1", "go_ids": [], "go_terms": [], "name": "SleB_dom1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042063": {"description": "Ubiquitin-activating enzyme E1, SCCH domain", "go_ids": [], "go_terms": [], "name": "Ubi_acti_E1_SCCH", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-MMU-9909505", "R-HSA-168928", "R-DDI-936440", "R-HSA-9918485", "R-MMU-5656169", "R-RNO-8866652", "R-HSA-936440", "R-HSA-983168", "R-HSA-1169408", "R-MMU-8866652", "R-MMU-1169408", "R-HSA-9909505", "R-DDI-983168", "R-HSA-8866652", "R-DDI-9909505", "R-BTA-8866652", "R-MMU-983168", "R-SPO-983168", "R-RNO-983168", "R-SCE-983168", "R-HSA-5656169", "R-DDI-1169408", "R-DDI-8866652"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "type": "Homologous_superfamily"}, "IPR042065": {"description": "E3 ubiquitin-protein ligase ELL-like", "go_ids": [], "go_terms": [], "name": "E3_ELL-like", "pathway_ids": ["R-DME-983168", "R-MMU-6796648", "R-HSA-6807505", "R-HSA-6781827", "R-HSA-167238", "R-DME-674695", "R-HSA-167243", "R-DME-6796648", "R-HSA-983168", "R-HSA-6796648", "R-DME-75955", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-MMU-6807505", "R-DME-351906", "R-HSA-167287", "R-DME-6807505", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-75955", "R-HSA-167152", "R-MMU-983168", "R-SPO-983168", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Homologous_superfamily"}, "IPR042066": {"description": "Spt6, Death-like domain", "go_ids": [], "go_terms": [], "name": "Spt6_death-like", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Homologous_superfamily"}, "IPR042070": {"description": "PucR C-terminal helix-turn-helix domain superfamily", "go_ids": [], "go_terms": [], "name": "PucR_C-HTH_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042071": {"description": "Phage late-transcription coactivator superfamily", "go_ids": [], "go_terms": [], "name": "Trans_coact_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042072": {"description": "DsrC-like protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DsrC-like_C", "pathway_ids": ["PWY-7889", "PWY-7888", "PWY-6892", "PWY-5303", "PWY-7904", "PWY-7250", "PWY-7892", "PWY-8164", "PWY-6675", "PWY-8179", "PWY-7891", "PWY-7887"], "pathways": ["PWY-7889:t:tRNA-uridine 2-thiolation (mammalian mitochondria)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6892:t:thiazole component of thiamine diphosphate biosynthesis I", "PWY-5303:t:thiosulfate oxidation II (via tetrathionate)", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-8164:t:bis(guanylyl molybdopterin) cofactor sulfurylation", "PWY-6675:t:sulfur oxidation IV (intracellular sulfur)", "PWY-8179:t:platensimycin biosynthesis", "PWY-7891:t:tRNA-uridine 2-thiolation (yeast mitochondria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation"], "type": "Homologous_superfamily"}, "IPR042073": {"description": "TraM, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "TraM_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042074": {"description": "Mycoplasma arthritidis-derived mitogen, C-terminal", "go_ids": [], "go_terms": [], "name": "M_arthritidis-der_mitogen_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042075": {"description": "KorB DNA-binding domain", "go_ids": [], "go_terms": [], "name": "KorB_DNA-db", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042076": {"description": "Crisp-like domain", "go_ids": [], "go_terms": [], "name": "Crisp-like_dom", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR042078": {"description": "Lysine tRNA ligase, stem contact fold domain", "go_ids": [], "go_terms": [], "name": "Lys-tRNA-ligase_SC_fold", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042079": {"description": "ATP synthase, F1 beta subunit superfamily", "go_ids": [], "go_terms": [], "name": "ATP_synt_F1_beta_sf", "pathway_ids": ["PWY-7980"], "pathways": ["PWY-7980:t:ATP biosynthesis"], "type": "Homologous_superfamily"}, "IPR042080": {"description": "RNA 2'-phosphotransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RNA_2'-PTrans_N", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Homologous_superfamily"}, "IPR042081": {"description": "RNA 2'-phosphotransferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RNA_2'-PTrans_C", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "type": "Homologous_superfamily"}, "IPR042082": {"description": "CST complex subunit Stn1, wHTH1 motif superfamily", "go_ids": [], "go_terms": [], "name": "CST_Stn1_wHTH1_sf", "pathway_ids": ["R-BTA-174411", "R-MMU-174430", "R-BTA-174430", "R-RNO-174430", "R-DRE-174430", "R-HSA-174430", "R-MMU-174411", "R-HSA-174411", "R-RNO-174411"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-BTA-174430:r:Telomere C-strand synthesis initiation", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere"], "type": "Homologous_superfamily"}, "IPR042085": {"description": "Alkaline phosphatase, crown domain", "go_ids": [], "go_terms": [], "name": "Ap_crown", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042086": {"description": "Methyltransferase, alpha-helical capping domain", "go_ids": [], "go_terms": [], "name": "MeTrfase_capping", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042087": {"description": "DNA polymerase family B, thumb domain", "go_ids": [], "go_terms": [], "name": "DNA_pol_B_thumb", "pathway_ids": ["R-DME-110314", "R-CEL-69091", "R-RNO-174437", "R-HSA-174414", "R-SPO-5656169", "R-SCE-69091", "R-HSA-5696397", "R-MMU-174417", "R-SPO-5656121", "R-DDI-6782210", "R-CEL-69166", "R-RNO-110314", "R-DME-5656121", "R-HSA-5655862", "R-DME-113501", "R-RNO-69183", "R-MMU-110314", "R-DME-68962", "R-HSA-174417", "R-CEL-110314", "R-MMU-174414", "R-DDI-68952", "R-RNO-5696397", "R-SPO-69091", "R-DDI-68962", "R-DME-5655862", "R-DME-69183", "R-MMU-174437", "R-RNO-5656169", "R-HSA-5656121", "R-MMU-5358606", "R-DME-6782135", "R-SCE-68952", "R-SPO-69166", "R-MMU-5358565", "R-RNO-6782210", "R-HSA-9610379", "R-DME-5651801", "R-HSA-68952", "R-SCE-69183", "R-DDI-113501", "R-MMU-68962", "R-MMU-5651801", "R-RNO-174430", "R-HSA-174430", "R-DDI-69183", "R-DME-69091", "R-CEL-6782210", "R-HSA-110312", "R-HSA-9609690", "R-MMU-69183", "R-HSA-9710421", "R-RNO-113501", "R-SPO-68952", "R-SPO-110314", "R-SCE-69166", "R-CEL-6782135", "R-MMU-6782210", "R-CEL-5651801", "R-SCE-110312", "R-MMU-174411", "R-MMU-5696397", "R-RNO-174414", "R-SCE-6782135", "R-HSA-110314", "R-SPO-5651801", "R-DDI-6782135", "R-MMU-174430", "R-RNO-68962", "R-HSA-5685942", "R-HSA-69205", "R-MMU-6782135", "R-SPO-5655862", "R-HSA-5358606", "R-MMU-110312", "R-SPO-110312", "R-RNO-69166", "R-CEL-69183", "R-DME-110312", "R-HSA-68962", "R-DME-68952", "R-HSA-6782210", "R-CEL-5656169", "R-RNO-68952", "R-HSA-5656169", "R-RNO-174411", "R-MMU-5696400", "R-MMU-5655862", "R-HSA-113501", "R-RNO-5358606", "R-HSA-2564830", "R-SPO-5696397", "R-RNO-5358565", "R-DDI-69091", "R-RNO-6782135", "R-SPO-69183", "R-MMU-113501", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-174411", "R-HSA-69166", "R-HSA-5651801", "R-SCE-68962", "R-SCE-113501", "R-CEL-5696397", "R-DDI-69166", "R-RNO-69091", "R-RNO-5685942", "R-MMU-68952", "R-DME-5656169", "R-MMU-5656121", "R-SPO-113501", "R-SPO-5696400", "R-DME-5696400", "R-SPO-6782210", "R-HSA-69183", "R-MMU-69166", "R-RNO-5696400", "R-RNO-174417", "R-SPO-68962", "R-HSA-5696400", "R-HSA-69091", "R-HSA-5358565", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-69091:r:Polymerase switching", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-SCE-69091:r:Polymerase switching", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-5656121:r:Translesion synthesis by POLI", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-68962:r:Activation of the pre-replicative complex", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-DDI-68952:r:DNA replication initiation", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SPO-69091:r:Polymerase switching", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-68952:r:DNA replication initiation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9610379:r:HCMV Late Events", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-68952:r:DNA replication initiation", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-DME-69091:r:Polymerase switching", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110312:r:Translesion synthesis by REV1", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-HSA-9710421:r:Defective pyroptosis", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-68952:r:DNA replication initiation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-110312:r:Translesion synthesis by REV1", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5656169:r:Termination of translesion DNA synthesis", "R-RNO-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-69091:r:Polymerase switching", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-69166:r:Removal of the Flap Intermediate", "R-RNO-69091:r:Polymerase switching", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-68952:r:DNA replication initiation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SPO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) 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"R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Homologous_superfamily"}, "IPR042090": {"description": "tRNA nucleotidyltransferase, domain 2", "go_ids": [], "go_terms": [], "name": "CCA_tRNA_nucleotrans_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042091": {"description": "Ska2, N-terminal", "go_ids": [], "go_terms": [], "name": "Ska2_N", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-RNO-2500257", "R-DRE-2500257", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-141444", "R-BTA-5663220", "R-DRE-2467813", "R-DRE-141444", "R-HSA-9648025", "R-RNO-5663220", "R-MMU-68877", "R-BTA-2467813", "R-HSA-68877", "R-BTA-2500257", "R-RNO-9648025", "R-RNO-2467813", "R-DRE-5663220", "R-HSA-5663220", "R-BTA-9648025", "R-BTA-141444", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", 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["R-RNO-71262", "R-MMU-71262", "R-GGA-71262", "R-SCE-71262", "R-CEL-71262", "R-HSA-71262", "R-BTA-71262"], "pathways": ["R-RNO-71262:r:Carnitine synthesis", "R-MMU-71262:r:Carnitine synthesis", "R-GGA-71262:r:Carnitine synthesis", "R-SCE-71262:r:Carnitine synthesis", "R-CEL-71262:r:Carnitine synthesis", "R-HSA-71262:r:Carnitine synthesis", "R-BTA-71262:r:Carnitine synthesis"], "type": "Homologous_superfamily"}, "IPR042099": {"description": "ANL, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ANL_N_sf", "pathway_ids": ["R-HSA-6798695", "R-HSA-1989781", "R-DDI-71384", "R-HSA-804914", "R-HSA-2151201", "R-DRE-77111", "R-HSA-389599", "R-HSA-177128", "R-RNO-2046106", "R-MMU-75876", "R-MTU-9635470", "R-HSA-2046105", "R-SCE-71384", "R-MMU-389599", "R-HSA-9841922", "R-RNO-9033241", "R-DRE-77289", "R-DME-71384", "R-RNO-77289", "R-RNO-434313", "R-MMU-9749641", "R-HSA-5619108", "R-HSA-77352", "R-SPO-75876", "R-MMU-434313", "R-HSA-193775", "R-HSA-177162", "R-RNO-77111", "R-BTA-77289", "R-HSA-71384", "R-MMU-2151201", "R-SCE-434313", "R-SPO-71384", "R-SCE-75876", "R-RNO-193775", "R-SCE-2046105", "R-RNO-389599", "R-RNO-177135", "R-HSA-75105", "R-HSA-390247", "R-MMU-390247", "R-HSA-9749641", "R-MMU-6798695", "R-RNO-193368", "R-MMU-177128", "R-MMU-77289", "R-DME-75876", "R-RNO-177128", "R-HSA-2046106", "R-RNO-6798695", "R-RNO-2046105", "R-MMU-177135", "R-RNO-75876", "R-MMU-193775", "R-BTA-77111", "R-SCE-2046106", "R-HSA-193368", "R-MMU-77111", "R-RNO-75105", "R-HSA-177135", "R-DDI-77111", "R-HSA-77111", "R-RNO-159418", "R-DDI-75876", "R-DDI-2046105", "R-CEL-77111", "R-RNO-804914", "R-MMU-2046106", "R-MMU-193368", "R-DDI-2046106", "R-HSA-2142753", "R-RNO-177162", "R-MMU-9033241", "R-MMU-177162", "R-MMU-75105", "R-MMU-804914", "R-HSA-434313", "R-RNO-9749641", "R-BTA-75876", "R-HSA-159418", "R-HSA-9033241", "R-SPO-434313", "R-HSA-75876", "R-MMU-159418", "R-MMU-2046105", "R-RNO-390247", "R-MMU-71384"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", 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"R-RNO-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-5619108:r:Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SPO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-HSA-177162:r:Conjugation of phenylacetate with glutamine", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-71384:r:Ethanol oxidation", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SCE-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-SPO-71384:r:Ethanol oxidation", "R-SCE-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-RNO-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-SCE-2046105:r:Linoleic acid (LA) metabolism", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-RNO-177135:r:Conjugation of benzoate with glycine", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-177128:r:Conjugation of salicylate with glycine", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-RNO-177128:r:Conjugation of salicylate with glycine", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-2046105:r:Linoleic acid (LA) metabolism", "R-MMU-177135:r:Conjugation of benzoate with glycine", "R-RNO-75876:r:Synthesis of very 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"R-HSA-2142753:r:Arachidonate metabolism", "R-RNO-177162:r:Conjugation of phenylacetate with glutamine", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-177162:r:Conjugation of phenylacetate with glutamine", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-804914:r:Transport of fatty acids", "R-HSA-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-RNO-9749641:r:Aspirin ADME", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9033241:r:Peroxisomal protein import", "R-SPO-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-2046105:r:Linoleic acid (LA) metabolism", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-71384:r:Ethanol oxidation"], "type": "Homologous_superfamily"}, "IPR042100": {"description": 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"R-CEL-73776", "R-DME-6782135", "R-BTA-72163", "R-SCE-76061", "R-BTA-75955", "R-DME-73762", "R-BTA-75953", "R-MMU-72163", "R-BTA-6782135", "R-SPO-76066", "R-SPO-9018519", "R-HSA-6803529", "R-HSA-167242", "R-CEL-6782210", "R-HSA-8851708", "R-CEL-674695", "R-HSA-167161", "R-HSA-72163", "R-DME-112382", "R-CEL-112382", "R-CEL-6782135", "R-HSA-9670095", "R-HSA-167160", "R-DDI-77075", "R-DDI-113418", "R-BTA-6782210", "R-MMU-73772", "R-MMU-72086", "R-SPO-73779", "R-BTA-73776", "R-SPO-73776", "R-SCE-73776", "R-DDI-76066", "R-HSA-6781827", "R-HSA-5578749", "R-SPO-76061", "R-DME-5578749", "R-DME-73779", "R-DME-77075", "R-BTA-5578749", "R-DME-9770562", "R-DME-73776", "R-BTA-6781823", "R-MMU-6781823", "R-HSA-203927", "R-DDI-73772", "R-DDI-6796648", "R-DDI-9018519", "R-HSA-6782210", "R-MMU-73776", "R-HSA-73780", "R-HSA-72165", "R-DDI-76042", "R-CEL-72163", "R-HSA-167172", "R-BTA-73779", "R-SCE-73779", "R-HSA-76071", "R-DME-113418", "R-CEL-75955", "R-MMU-6796648", "R-HSA-72203", "R-BTA-72165", 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"R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-SPO-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-72086:r:mRNA Capping", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-DDI-72086:r:mRNA Capping", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Homologous_superfamily"}, "IPR042103": {"description": "Serine-tRNA synthetase, type1, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "SerRS_1_N_sf", "pathway_ids": ["PWY-6281", "R-HSA-379716", "R-HSA-379726", "R-HSA-2408557"], "pathways": ["PWY-6281:t:L-selenocysteine biosynthesis II (archaea and eukaryotes)", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-2408557:r:Selenocysteine synthesis"], "type": "Homologous_superfamily"}, "IPR042104": {"description": "Polyketide synthase, dehydratase domain superfamily", "go_ids": [], "go_terms": [], "name": "PKS_dehydratase_sf", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-DDI-75105", "R-HSA-75105", "R-DDI-199220", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Homologous_superfamily"}, "IPR042105": {"description": "Large ribosomal subunit protein bL31 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL31_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042106": {"description": "NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ", "go_ids": [], "go_terms": [], "name": "Nuo/plastoQ_OxRdtase_6_NuoJ", "pathway_ids": ["R-RNO-611105", "R-GGA-5419276", "R-RNO-5419276", "R-SSC-5419276", "R-MMU-6799198", "R-GGA-611105", "R-MMU-611105", "R-MMU-5419276", "R-RNO-6799198", "R-BTA-5419276", "R-SSC-6799198", "R-BTA-6799198", "R-GGA-6799198", "R-SSC-611105", "R-BTA-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-SSC-5419276:r:Mitochondrial translation termination", "R-MMU-6799198:r:Complex I biogenesis", "R-GGA-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-RNO-6799198:r:Complex I biogenesis", "R-BTA-5419276:r:Mitochondrial translation termination", "R-SSC-6799198:r:Complex I biogenesis", "R-BTA-6799198:r:Complex I biogenesis", "R-GGA-6799198:r:Complex I biogenesis", "R-SSC-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Homologous_superfamily"}, "IPR042107": {"description": "DNA-directed RNA polymerase, beta subunit, external 1 domain superfamily", "go_ids": [], "go_terms": [], "name": "DNA-dir_RNA_pol_bsu_ext_1_sf", "pathway_ids": ["R-HSA-9639775"], "pathways": ["R-HSA-9639775:r:Antimicrobial action and antimicrobial resistance in Mtb"], "type": "Homologous_superfamily"}, "IPR042108": {"description": "GTPase HflX, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "GTPase_HflX_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042109": {"description": "Adenylosuccinate synthetase, domain 1", "go_ids": [], "go_terms": [], "name": "Adenylosuccinate_synth_dom1", "pathway_ids": ["PWY-7219", "R-SPO-73817", "R-XTR-73817", "R-DDI-73817", "R-GGA-421203", "R-DME-73817", "R-BTA-73817", "R-MMU-73817", "R-SCE-73817", "R-CEL-73817", "R-SSC-73817", "R-HSA-73817", "R-PFA-73817", "R-DRE-73817"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-XTR-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-421203:r:De novo synthesis of AMP", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SSC-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DRE-73817:r:Purine ribonucleoside monophosphate biosynthesis"], "type": "Homologous_superfamily"}, "IPR042110": {"description": "Adenylosuccinate synthetase, domain 2", "go_ids": [], "go_terms": [], "name": "Adenylosuccinate_synth_dom2", "pathway_ids": ["PWY-7219", "R-SPO-73817", "R-XTR-73817", "R-DDI-73817", "R-GGA-421203", "R-DME-73817", "R-BTA-73817", "R-MMU-73817", "R-SCE-73817", "R-CEL-73817", "R-SSC-73817", "R-HSA-73817", "R-PFA-73817", "R-DRE-73817"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-XTR-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-421203:r:De novo synthesis of AMP", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SSC-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DRE-73817:r:Purine ribonucleoside monophosphate biosynthesis"], "type": "Homologous_superfamily"}, "IPR042111": {"description": "Adenylosuccinate synthetase, domain 3", "go_ids": [], "go_terms": [], "name": "Adenylosuccinate_synth_dom3", "pathway_ids": ["PWY-7219", "R-SPO-73817", "R-XTR-73817", "R-DDI-73817", "R-GGA-421203", "R-DME-73817", "R-BTA-73817", "R-MMU-73817", "R-SCE-73817", "R-CEL-73817", "R-SSC-73817", "R-HSA-73817", "R-PFA-73817", "R-DRE-73817"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-XTR-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-GGA-421203:r:De novo synthesis of AMP", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-BTA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SSC-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-PFA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DRE-73817:r:Purine ribonucleoside monophosphate biosynthesis"], "type": "Homologous_superfamily"}, "IPR042112": {"description": "Phosphate acetyltransferase, domain 2", "go_ids": [], "go_terms": [], "name": "P_AcTrfase_dom2", "pathway_ids": ["PWY-8086", "PWY-1281", "PWY-8377", "PWY-5497", "PWY-5485", "PWY-6637", "PWY-5482"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1281:t:sulfoacetaldehyde degradation I", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-5485:t:pyruvate fermentation to acetate IV", "PWY-6637:t:sulfolactate degradation II", "PWY-5482:t:pyruvate fermentation to acetate II"], "type": "Homologous_superfamily"}, "IPR042113": {"description": "Phosphate acetyltransferase, domain 1", "go_ids": [], "go_terms": [], "name": "P_AcTrfase_dom1", "pathway_ids": ["PWY-8086", "PWY-1281", "PWY-8377", "PWY-5497", "PWY-5485", "PWY-6637", "PWY-5482"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1281:t:sulfoacetaldehyde degradation I", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-5485:t:pyruvate fermentation to acetate IV", "PWY-6637:t:sulfolactate degradation II", "PWY-5482:t:pyruvate fermentation to acetate II"], "type": "Homologous_superfamily"}, "IPR042114": {"description": "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 1", "go_ids": [], "go_terms": [], "name": "GatB_C_1", "pathway_ids": ["PWY-8229", "PWY-5297", "PWY-7811"], "pathways": ["PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-5297:t:siroheme amide biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis"], "type": "Homologous_superfamily"}, "IPR042115": {"description": "Primosomal protein N', 3' DNA-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "PriA_3primeBD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042116": {"description": "GTP-binding protein TypA/BipA, C-terminal", "go_ids": [], "go_terms": [], "name": "TypA/BipA_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042118": {"description": "QueA, domain 1", "go_ids": [], "go_terms": [], "name": "QueA_dom1", "pathway_ids": ["PWY-6700", "PWY-8106"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Homologous_superfamily"}, "IPR042119": {"description": "QueA, domain 2", "go_ids": [], "go_terms": [], "name": "QueA_dom2", "pathway_ids": ["PWY-6700", "PWY-8106"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Homologous_superfamily"}, "IPR042120": {"description": "MutL, C-terminal domain, dimerisation subdomain", "go_ids": [], "go_terms": [], "name": "MutL_C_dimsub", "pathway_ids": ["R-GGA-5358565", "R-HSA-5545483", "R-SCE-5358565", "R-SPO-5358565", "R-HSA-912446", "R-HSA-5358606", "R-HSA-5358565", "R-DDI-5358565", "R-HSA-6796648", "R-MMU-5358565", "R-HSA-5632987"], "pathways": ["R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632987:r:Defective Mismatch Repair Associated With PMS2"], "type": "Homologous_superfamily"}, "IPR042121": {"description": "MutL, C-terminal domain, regulatory subdomain", "go_ids": [], "go_terms": [], "name": "MutL_C_regsub", "pathway_ids": ["R-GGA-5358565", "R-HSA-5545483", "R-SCE-5358565", "R-SPO-5358565", "R-HSA-912446", "R-HSA-5358606", "R-HSA-5358565", "R-DDI-5358565", "R-HSA-6796648", "R-MMU-5358565", "R-HSA-5632987"], "pathways": ["R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632987:r:Defective Mismatch Repair Associated With PMS2"], "type": "Homologous_superfamily"}, "IPR042122": {"description": "Serine acetyltransferase, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Ser_AcTrfase_N_sf", "pathway_ids": ["PWY-7274", "PWY-7870", "PWY-6936", "PWY-8071", "R-MTU-936721"], "pathways": ["PWY-7274:t:D-cycloserine biosynthesis", "PWY-7870:t:L-cysteine biosynthesis VII (from S-sulfo-L-cysteine)", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-8071:t:N-3-oxalyl-L-2,3-diaminopropanoate biosynthesis", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Homologous_superfamily"}, "IPR042123": {"description": "Zip3/RNF212-like", "go_ids": ["GO:0000795", "GO:0019789", "GO:0007131"], "go_terms": ["GO:0000795:synaptonemal complex:C", "GO:0019789:SUMO transferase activity:F", "GO:0007131:reciprocal meiotic recombination:P"], "name": "Zip3/RNF212-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042125": {"description": "Small integral membrane protein 11", "go_ids": [], "go_terms": [], "name": "SMIM11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042127": {"description": "Transmembrane protein 45", "go_ids": [], "go_terms": [], "name": "TMEM45", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042150": {"description": "CAAX prenyl protease 2, MmRce1-like", "go_ids": [], "go_terms": [], "name": "MmRce1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042160": {"description": "Class IV homeodomain-leucine zipper", "go_ids": [], "go_terms": [], "name": "HD-Zip_IV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042161": {"description": "Tetratricopeptide repeat protein 34", "go_ids": [], "go_terms": [], "name": "TTC34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042162": {"description": "Chaperone protein DnaJ 13", "go_ids": [], "go_terms": [], "name": "AtJ13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042163": {"description": "PHD finger protein 12", "go_ids": ["GO:0045892", "GO:0003714"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P", "GO:0003714:transcription corepressor activity:F"], "name": "PHF12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042164": {"description": "Solute carrier family 25 member 44", "go_ids": ["GO:0009083", "GO:0015658", "GO:0005739"], "go_terms": ["GO:0009083:branched-chain amino acid catabolic process:P", "GO:0015658:branched-chain amino acid transmembrane transporter activity:F", "GO:0005739:mitochondrion:C"], "name": "SLC25A44", "pathway_ids": ["R-HSA-70895"], "pathways": ["R-HSA-70895:r:Branched-chain amino acid catabolism"], "type": "Family"}, "IPR042165": {"description": "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1", "go_ids": ["GO:0004721"], "go_terms": ["GO:0004721:phosphoprotein phosphatase activity:F"], "name": "PTPMT1", "pathway_ids": ["PWY-5668", "PWY-7817", "PWY-5269", "R-HSA-1483148"], "pathways": ["PWY-5668:t:cardiolipin biosynthesis I", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-5269:t:cardiolipin biosynthesis II", "R-HSA-1483148:r:Synthesis of PG"], "type": "Family"}, "IPR042166": {"description": "Vesicle-associated membrane protein 5", "go_ids": [], "go_terms": [], "name": "Vamp5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042167": {"description": "Serine protease inhibitor Kazal-type 2", "go_ids": ["GO:0007286", "GO:0004867"], "go_terms": ["GO:0007286:spermatid development:P", "GO:0004867:serine-type endopeptidase inhibitor activity:F"], "name": "SPINK2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042168": {"description": "Purkinje cell protein 2", "go_ids": ["GO:0005085"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "Pcp2", "pathway_ids": ["R-MMU-418594", "R-HSA-418594"], "pathways": ["R-MMU-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR042169": {"description": "NKG2-D type II integral membrane protein", "go_ids": ["GO:0045954"], "go_terms": ["GO:0045954:positive regulation of natural killer cell mediated cytotoxicity:P"], "name": "NKG2D", "pathway_ids": ["R-HSA-198933", "R-MMU-198933", "R-RNO-2424491", "R-RNO-198933", "R-HSA-2424491", "R-HSA-2172127", "R-MMU-2424491"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-2172127:r:DAP12 interactions", "R-MMU-2424491:r:DAP12 signaling"], "type": "Family"}, "IPR042171": {"description": "Acyl-CoA thioesterase, double hotdog domain", "go_ids": [], "go_terms": [], "name": "Acyl-CoA_hotdog", "pathway_ids": ["R-MMU-2046106", "R-MMU-193368", "R-SCE-2046106", "R-RNO-2046106", "R-SCE-390247", "R-HSA-389887", "R-HSA-193368", "R-MMU-9033241", "R-RNO-9033241", "R-MMU-389887", "R-SCE-389887", "R-RNO-389887", "R-HSA-390247", "R-MMU-390247", "R-SCE-9033241", "R-RNO-193368", "R-SCE-193368", "R-HSA-2046106", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SCE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SCE-390247:r:Beta-oxidation 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"R-HSA-5578997:r:Defective AHCY causes HMAHCHD", "R-DME-156581:r:Methylation", "R-SCE-156581:r:Methylation", "R-SCE-1614635:r:Sulfur amino acid metabolism", "R-HSA-1489509:r:DAG and IP3 signaling", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-SPO-156581:r:Methylation", "R-HSA-112043:r:PLC beta mediated events", "R-SPO-1614635:r:Sulfur amino acid metabolism", "R-BTA-1614635:r:Sulfur amino acid metabolism", "R-RNO-156581:r:Methylation", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-5578775:r:Ion homeostasis", "R-DME-425381:r:Bicarbonate transporters", "R-DDI-156581:r:Methylation", "R-BTA-425381:r:Bicarbonate transporters", "R-HSA-425381:r:Bicarbonate transporters", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-156581:r:Methylation", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-BTA-156581:r:Methylation", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-DME-1614635:r:Sulfur amino acid metabolism", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Homologous_superfamily"}, "IPR042173": {"description": "Ribonuclease J, domain 2", "go_ids": [], "go_terms": [], "name": "RNase_J_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042174": {"description": "DNA-binding RecF, domain 2", "go_ids": [], "go_terms": [], "name": "RecF_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042175": {"description": "Cell/Rod shape-determining protein MreC, domain 2", "go_ids": [], "go_terms": [], "name": 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"R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-RNO-6783984:r:Glycine degradation", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SSC-6783984:r:Glycine degradation", "R-CEL-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-BTA-6783984:r:Glycine degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-HSA-6783984:r:Glycine degradation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-DDI-6783984:r:Glycine degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SPO-6783984:r:Glycine degradation", "R-DRE-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-DME-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-BTA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG"], "type": "Homologous_superfamily"}, "IPR042183": {"description": "MmgE/PrpD superfamily, domain 1", "go_ids": [], "go_terms": [], "name": "MmgE/PrpD_sf_1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042184": {"description": "YqeY/Aim41, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YqeY/Aim41_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042185": {"description": "Serpin superfamily, domain 2", "go_ids": [], "go_terms": [], "name": "Serpin_sf_2", "pathway_ids": ["R-HSA-6798695", "R-MMU-416476", "R-HSA-1989781", "R-MMU-204005", "R-GGA-8939242", "R-HSA-3000178", "R-HSA-140837", "R-MMU-5694530", "R-RNO-140875", "R-BTA-6798695", "R-BTA-9757110", "R-MMU-375276", "R-HSA-9686347", "R-HSA-1368108", "R-HSA-5694530", "R-MMU-8957275", "R-HSA-1650814", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-BTA-418594", "R-BTA-9948001", "R-MMU-3000178", "R-MMU-381426", "R-HSA-9926550", "R-DME-140875", "R-BTA-204005", "R-RNO-416476", "R-HSA-75205", "R-RNO-3000178", "R-HSA-381426", "R-SSC-3000178", "R-DME-5694530", "R-MMU-2022377", "R-GGA-1650814", "R-DME-1650814", "R-BTA-194002", "R-DME-114608", "R-MMU-140837", "R-HSA-8950505", "R-HSA-2022377", "R-HSA-9948001", "R-GGA-6798695", "R-BTA-416476", "R-HSA-204005", "R-RNO-381426", "R-DME-9948001", "R-BTA-5694530", "R-DME-8939242", "R-DME-9757110", "R-MMU-6798695", "R-HSA-8939242", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608", "R-MMU-9757110", "R-DME-204005", "R-DME-194002", "R-DME-381426", "R-DME-8957275", "R-HSA-9757110", "R-HSA-9657689", "R-HSA-375276", "R-SSC-114608", "R-DME-2022377", "R-HSA-9925561", "R-HSA-416476", "R-MMU-8939242", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-9757110", "R-HSA-114608", "R-BTA-114608", "R-HSA-5357905", "R-HSA-977606", "R-RNO-8957275", "R-DME-140837", "R-BTA-381426", "R-MMU-194002", "R-RNO-75205", "R-HSA-2173796", "R-BTA-1650814", "R-RNO-1650814", "R-RNO-5694530", "R-MMU-977606", "R-BTA-2022377", "R-DME-6798695", "R-MMU-75205", "R-RNO-2022377", "R-SSC-75205", "R-HSA-140875", "R-RNO-194002", "R-RNO-204005", "R-MMU-140875", "R-HSA-418594", "R-MMU-1650814", "R-RNO-375276", "R-MMU-9948001", "R-BTA-75205", "R-HSA-8957275", "R-DME-209442", "R-HSA-194002"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-GGA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-5694530:r:Cargo concentration in the ER", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-9757110:r:Prednisone ADME", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-5694530:r:Cargo concentration in the ER", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-BTA-418594:r:G alpha (i) signalling events", "R-BTA-9948001:r:CASP4 inflammasome assembly", "R-MMU-3000178:r:ECM proteoglycans", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-DME-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-3000178:r:ECM proteoglycans", "R-DME-5694530:r:Cargo concentration in the ER", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-GGA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-BTA-194002:r:Glucocorticoid biosynthesis", "R-DME-114608:r:Platelet degranulation", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9948001:r:CASP4 inflammasome assembly", "R-GGA-6798695:r:Neutrophil degranulation", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-9948001:r:CASP4 inflammasome assembly", "R-BTA-5694530:r:Cargo concentration in the ER", "R-DME-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-DME-9757110:r:Prednisone ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation", "R-MMU-9757110:r:Prednisone ADME", "R-DME-204005:r:COPII-mediated vesicle transport", "R-DME-194002:r:Glucocorticoid biosynthesis", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-HSA-9757110:r:Prednisone ADME", "R-HSA-9657689:r:Defective SERPING1 causes hereditary angioedema", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-SSC-114608:r:Platelet degranulation", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-8939242:r:RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-9757110:r:Prednisone ADME", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-DME-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-5694530:r:Cargo concentration in the ER", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-SSC-75205:r:Dissolution of Fibrin Clot", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-194002:r:Glucocorticoid biosynthesis", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-9948001:r:CASP4 inflammasome assembly", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-HSA-194002:r:Glucocorticoid biosynthesis"], "type": "Homologous_superfamily"}, "IPR042186": {"description": "Outer membrane usher protein FimD, plug domain", "go_ids": [], "go_terms": [], "name": "FimD_plug_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042187": {"description": "Flagellin, C-terminal domain, subdomain 2", "go_ids": ["GO:0009288"], "go_terms": ["GO:0009288:bacterial-type flagellum:C"], "name": "Flagellin_C_sub2", "pathway_ids": ["R-GGA-433822", "R-HSA-975871", "R-GGA-977240", "R-GGA-451534", "R-HSA-168176", "R-HSA-5602680", "R-HSA-5603037", "R-HSA-844623"], "pathways": ["R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-GGA-977240:r:MyD88 cascade initiated on plasma membrane", "R-GGA-451534:r:TLR5 cascade", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Homologous_superfamily"}, "IPR042188": {"description": "MmgE/PrpD superfamily, domain 2", "go_ids": [], "go_terms": [], "name": "MmgE/PrpD_sf_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042189": {"description": "Sigma-70 factor, region 1.1 superfamily", "go_ids": ["GO:0016987"], "go_terms": ["GO:0016987:sigma factor activity:F"], "name": "RNA_pol_sigma_70_r1_1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042190": {"description": "Killer cell lectin-like receptor subfamily G member 1", "go_ids": [], "go_terms": [], "name": "KLRG1", "pathway_ids": ["R-HSA-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR042191": {"description": "GS homeobox 1/2", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "GSH1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042192": {"description": "Glycophorin-C", "go_ids": [], "go_terms": [], "name": "Glycophorin-C", "pathway_ids": ["R-HSA-202733"], "pathways": ["R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR042193": {"description": "FHIPEP, domain 3", "go_ids": [], "go_terms": [], "name": "FHIPEP_3", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042194": {"description": "FHIPEP, domain 1", "go_ids": [], "go_terms": [], "name": "FHIPEP_1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042195": {"description": "ArgJ beta chain, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ArgJ_beta_C", "pathway_ids": ["PWY-5154"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Homologous_superfamily"}, "IPR042196": {"description": "FHIPEP, domain 4", "go_ids": [], "go_terms": [], "name": "FHIPEP_4", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042197": {"description": "Apoptotic protease-activating factors, helical domain", "go_ids": [], "go_terms": [], "name": "Apaf_helical", "pathway_ids": ["R-HSA-111459", "R-HSA-6798695", "R-DRE-111459", "R-HSA-6803207", "R-HSA-111464", "R-HSA-111458", "R-MMU-111458", "R-DRE-111458", "R-RNO-111459", "R-HSA-8953750", "R-DRE-9627069", "R-MMU-111459", "R-RNO-111458", "R-MMU-9627069", "R-DRE-6798695", "R-RNO-9627069", "R-MMU-6798695", "R-HSA-9627069", "R-HSA-111463", "R-RNO-6798695"], "pathways": ["R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-111458:r:Formation of apoptosome", "R-MMU-111458:r:Formation of apoptosome", "R-DRE-111458:r:Formation of apoptosome", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-111458:r:Formation of apoptosome", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR042199": {"description": "Aspartokinase/Bifunctional aspartokinase/homoserine dehydrogenase, catalytic domain", "go_ids": [], "go_terms": [], "name": "AsparK_Bifunc_asparK/hSer_DH", "pathway_ids": ["PWY-7977", "PWY-6562", "PWY-2942", "PWY-8088", "PWY-8296", "PWY-6559", "PWY-6160", "PWY-5097", "PWY-7153", "PWY-8179", "PWY-2941"], "pathways": ["PWY-7977:t:L-methionine biosynthesis IV", "PWY-6562:t:norspermidine biosynthesis", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8088:t:dipicolinate biosynthesis", "PWY-8296:t:cremeomycin biosynthesis", "PWY-6559:t:spermidine biosynthesis II", "PWY-6160:t:3-dehydroquinate biosynthesis II (archaea)", "PWY-5097:t:L-lysine biosynthesis VI", "PWY-7153:t:grixazone biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Homologous_superfamily"}, "IPR042201": {"description": "Formin, FH2 domain superfamily", "go_ids": [], "go_terms": [], "name": "FH2_Formin_sf", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-MMU-6785631", "R-HSA-6798695", "R-HSA-9013409", "R-RNO-6785631", "R-CEL-8980692", "R-MMU-9013106", "R-CEL-5663220", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-BTA-5663220", "R-HSA-9013106", "R-MMU-9013404", "R-HSA-9013423", "R-DME-9035034", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013406", "R-RNO-9013404", "R-RNO-9013406", "R-RNO-9013106", "R-RNO-9013408", "R-DME-5663220", "R-DME-9013423", "R-DRE-5663220", "R-HSA-9013408", "R-MMU-5663220", "R-MMU-9035034", "R-DME-9013149", "R-DRE-9013106", "R-DME-8980692", "R-DME-6798695", "R-DME-6785631", "R-MMU-4086400", "R-HSA-4086400", "R-HSA-6785631", "R-RNO-5663220", "R-RNO-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-HSA-8980692", "R-HSA-9854909", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9013026", "R-MMU-6798695", "R-HSA-5663220", "R-DRE-8980692", "R-HSA-9013406", "R-MMU-9013149", "R-BTA-9013106", "R-RNO-6798695"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-5663220:r:RHO GTPases Activate Formins", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DRE-9013106:r:RHOC GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-4086400:r:PCP/CE pathway", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR042202": {"description": "Duffy-antigen binding superfamily", "go_ids": [], "go_terms": [], "name": "Duffy-ag-bd_sf", "pathway_ids": ["R-HSA-202733"], "pathways": ["R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Homologous_superfamily"}, "IPR042203": {"description": "Leucyl/phenylalanyl-tRNA-protein transferase, C-terminal", "go_ids": [], "go_terms": [], "name": "Leu/Phe-tRNA_Trfase_C", "pathway_ids": ["PWY-7801"], "pathways": ["PWY-7801:t:N-end rule pathway I (prokaryotic)"], "type": "Homologous_superfamily"}, "IPR042204": {"description": "2Fe-2S iron-sulfur cluster binding domain, N-terminal", "go_ids": [], "go_terms": [], "name": "2Fe-2S-bd_N", "pathway_ids": ["PWY-3661"], "pathways": ["PWY-3661:t:glycine betaine degradation I"], "type": "Homologous_superfamily"}, "IPR042205": {"description": "Hepatitis C virus non-structural protein NS2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HCV_NS2_C", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Homologous_superfamily"}, "IPR042206": {"description": "CRISPR-associated endonuclease Cas1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Cas1_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042207": {"description": "Glycoprotein VP7, domain 1", "go_ids": [], "go_terms": [], "name": "VP7_1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042208": {"description": "D-serine dehydratase-like domain superfamily", "go_ids": [], "go_terms": [], "name": "D-ser_dehydrat-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042209": {"description": "Hepatitis C virus non-structural protein NS2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HCV_NS2_N", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Homologous_superfamily"}, "IPR042210": {"description": "Glycoprotein VP7, domain 2", "go_ids": [], "go_terms": [], "name": "VP7_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042211": {"description": "CRISPR-associated endonuclease Cas1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Cas1_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042213": {"description": "Four-carbon acid sugar kinase, nucleotide binding domain superfamily", "go_ids": [], "go_terms": [], "name": "NBD_C_sf", "pathway_ids": ["PWY-7873", "PWY-7874"], "pathways": ["PWY-7873:t:D-erythronate degradation II", "PWY-7874:t:L-threonate degradation"], "type": "Homologous_superfamily"}, "IPR042214": {"description": "Pseudouridine synthase, TruD, catalytic domain", "go_ids": [], "go_terms": [], "name": "TruD_catalytic", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Homologous_superfamily"}, "IPR042215": {"description": "CarD-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CarD-like_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042216": {"description": "MitoNEET, CDGSH iron-sulfur domain", "go_ids": [], "go_terms": [], "name": "MitoNEET_CISD", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042217": {"description": "Type IV secretion system, VirB10/TrbI", "go_ids": [], "go_terms": [], "name": "T4SS_VirB10/TrbI", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042219": {"description": "Dynein heavy chain, AAA lid domain superfamily", "go_ids": [], "go_terms": [], "name": "AAA_lid_11_sf", "pathway_ids": ["R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259", "R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497"], "pathways": ["R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "type": "Homologous_superfamily"}, "IPR042220": {"description": "NLR family CARD domain-containing protein 4", "go_ids": [], "go_terms": [], "name": "NLRC4", "pathway_ids": ["R-HSA-6803207", "R-HSA-844623"], "pathways": ["R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Family"}, "IPR042221": {"description": "Leucyl/phenylalanyl-tRNA-protein transferase, N-terminal", "go_ids": [], "go_terms": [], "name": "Leu/Phe-tRNA_Trfase_N", "pathway_ids": ["PWY-7801"], "pathways": ["PWY-7801:t:N-end rule pathway I (prokaryotic)"], "type": "Homologous_superfamily"}, "IPR042222": {"description": "Dynein heavy chain, domain 2, N-terminal", "go_ids": [], "go_terms": [], "name": "Dynein_2_N", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from 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kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Homologous_superfamily"}, "IPR042223": {"description": "Homeobox protein SEBOX", "go_ids": [], "go_terms": [], "name": "SEBOX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042224": {"description": "General transcription factor II-I repeat domain-containing protein 2", "go_ids": [], "go_terms": [], "name": "GTF2IRD2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042225": {"description": "Negative cofactor 2 complex subunit beta", "go_ids": ["GO:0000122", "GO:0017054", "GO:0140223"], "go_terms": ["GO:0000122:negative regulation of transcription by RNA polymerase II:P", "GO:0017054:negative cofactor 2 complex:C", "GO:0140223:general transcription initiation factor activity:F"], "name": "Ncb2", "pathway_ids": ["R-MMU-9772755", "R-HSA-3214847", "R-RNO-9772755", "R-HSA-9772755"], "pathways": ["R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Family"}, "IPR042226": {"description": "eRF1, domain 2 superfamily", "go_ids": [], "go_terms": [], "name": "eFR1_2_sf", "pathway_ids": ["R-RNO-9629569", "R-DDI-975956", "R-BTA-975957", "R-CEL-975957", "R-SPO-72764", "R-HSA-9010553", "R-SPO-9954714", "R-CEL-9629569", "R-XTR-975956", "R-SPO-975957", "R-CEL-72764", "R-HSA-975956", "R-XTR-975957", "R-CEL-975956", "R-DME-72764", "R-SCE-975957", "R-BTA-72764", "R-CEL-9954714", "R-SCE-72764", "R-MMU-975956", "R-HSA-9629569", "R-RNO-975957", "R-MMU-72764", "R-SPO-975956", "R-DME-975956", "R-DRE-9954714", "R-MMU-9954714", "R-SCE-975956", "R-SPO-9629569", "R-MMU-975957", "R-DME-9629569", "R-DDI-72764", "R-HSA-72764", "R-SCE-9954714", "R-HSA-9954714", "R-HSA-975957", "R-MMU-9629569", "R-DME-9954714", "R-XTR-72764", "R-RNO-975956", "R-BTA-975956", "R-DDI-975957", "R-XTR-9629569", "R-BTA-9629569", "R-DME-975957", "R-RNO-9954714"], "pathways": ["R-RNO-9629569:r:Protein hydroxylation", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72764:r:Eukaryotic Translation Termination", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9629569:r:Protein hydroxylation", "R-XTR-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-72764:r:Eukaryotic Translation Termination", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-XTR-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-72764:r:Eukaryotic Translation Termination", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-72764:r:Eukaryotic Translation Termination", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-72764:r:Eukaryotic Translation Termination", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9629569:r:Protein hydroxylation", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-72764:r:Eukaryotic Translation Termination", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-9629569:r:Protein hydroxylation", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9629569:r:Protein hydroxylation", "R-DDI-72764:r:Eukaryotic Translation Termination", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9629569:r:Protein hydroxylation", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-XTR-72764:r:Eukaryotic Translation Termination", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-XTR-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "type": "Homologous_superfamily"}, "IPR042227": {"description": "NF-kappa-B inhibitor-interacting Ras-like 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"R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation"], "type": "Family"}, "IPR042228": {"description": "Dynein heavy chain, linker, subdomain 3", "go_ids": [], "go_terms": [], "name": "Dynein_linker_3", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", 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"R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic 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gene expression", "R-SCE-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-SCE-9033241:r:Peroxisomal protein import", "R-BTA-200425:r:Carnitine shuttle", "R-SCE-1483191:r:Synthesis of PC", "R-DME-1483191:r:Synthesis of PC", "R-HSA-9033241:r:Peroxisomal protein import", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-BTA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SSC-1483191:r:Synthesis of PC"], "type": "Homologous_superfamily"}, "IPR042233": {"description": "Cell division protein ZapA, N-terminal", "go_ids": [], "go_terms": [], "name": "Cell_div_ZapA_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042234": {"description": "WD repeat and FYVE domain-containing protein 1/2", "go_ids": [], "go_terms": [], "name": "WDFY1/WDFY2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042235": {"description": "Zona pellucida, ZP-C domain", "go_ids": [], "go_terms": [], "name": "ZP-C_dom", "pathway_ids": ["R-MMU-9839406", 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"R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-BTA-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-416476:r:G alpha (q) signalling events", "R-CEL-210993:r:Tie2 Signaling", "R-MMU-9607240:r:FLT3 Signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-5654710:r:PI-3K cascade:FGFR3", "R-BTA-202424:r:Downstream TCR signaling", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-912631:r:Regulation of signaling by CBL", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-112399:r:IRS-mediated signalling", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-BTA-8853659:r:RET signaling", "R-SCE-1483248:r:Synthesis of PIPs at the ER membrane", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-BTA-112399:r:IRS-mediated signalling", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-RNO-9927354:r:Co-stimulation by ICOS", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-201556:r:Signaling by ALK", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-HSA-373753:r:Nephrin family interactions", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-1483248:r:Synthesis of PIPs at the ER membrane", "R-CEL-201556:r:Signaling by ALK", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-8853659:r:RET signaling", "R-CEL-180292:r:GAB1 signalosome", "R-MMU-8853659:r:RET signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-BTA-912631:r:Regulation of signaling by CBL", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-HSA-1632852:r:Macroautophagy", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-CEL-186763:r:Downstream signal transduction", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-198203:r:PI3K/AKT activation", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-1632852:r:Macroautophagy", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-392451:r:G beta:gamma signalling through PI3Kgamma", "R-DDI-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-CEL-1632852:r:Macroautophagy", "R-RNO-109704:r:PI3K Cascade", "R-CEL-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-416476:r:G alpha (q) signalling events", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-9842663:r:Signaling by LTK", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-BTA-186763:r:Downstream signal transduction", "R-MMU-198203:r:PI3K/AKT activation", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-BTA-201556:r:Signaling by ALK", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-BTA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-112399:r:IRS-mediated signalling", "R-HSA-186763:r:Downstream signal transduction", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-RNO-2424491:r:DAP12 signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-2424491:r:DAP12 signaling", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-202424:r:Downstream TCR signaling", "R-RNO-186763:r:Downstream signal transduction", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma"], "type": "Homologous_superfamily"}, "IPR042237": {"description": "Putative peptidyl-tRNA hydrolase PTRHD1", "go_ids": [], "go_terms": [], "name": "PTRHD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042238": {"description": "DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1", "go_ids": ["GO:0006283"], "go_terms": ["GO:0006283:transcription-coupled nucleotide-excision 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"R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-SPO-8951664:r:Neddylation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Family"}, "IPR042239": {"description": "Nop, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Nop_C", "pathway_ids": ["R-MMU-6791226", "R-SCE-4570464", "R-HSA-390471", "R-MMU-72163", "R-DDI-6791226", "R-DDI-4570464", "R-MMU-4570464", "R-HSA-6790901", "R-RNO-6791226", "R-HSA-72163", "R-SPO-4570464", "R-SCE-6791226", "R-HSA-6791226", "R-RNO-4570464", "R-HSA-4570464", "R-CEL-6791226", "R-SPO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Homologous_superfamily"}, "IPR042240": {"description": "CHASE domain superfamily", "go_ids": [], "go_terms": [], "name": "CHASE_sf", "pathway_ids": ["R-DDI-2514859"], "pathways": ["R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Homologous_superfamily"}, "IPR042241": {"description": "Gamma tubulin complex component, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "GCP_C_sf", "pathway_ids": ["R-HSA-380320", "R-MMU-380270", "R-HSA-380270", "R-MMU-380320"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes"], "type": "Homologous_superfamily"}, "IPR042242": {"description": "Recombination protein O, C-terminal", "go_ids": [], "go_terms": [], "name": "RecO_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042243": {"description": "HypD, domain 1", "go_ids": [], "go_terms": [], "name": "HypD_1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042244": {"description": "HypD, domain 2", "go_ids": [], "go_terms": [], "name": "HypD_2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042245": {"description": "Tgt2/MlaC superfamily", "go_ids": [], "go_terms": [], "name": "Tgt2/MlaC_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042246": {"description": "Zinc finger CCHC domain-containing protein 9", "go_ids": [], "go_terms": [], "name": "ZCCHC9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042247": {"description": "T-cell leukemia homeobox protein 1/2/3", "go_ids": ["GO:0003700", "GO:0003677"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0003677:DNA binding:F"], "name": "TLX1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042251": {"description": "Ethanolamine ammonia-lyase light chain, C-terminal", "go_ids": [], "go_terms": [], "name": "EutC_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042252": {"description": "MtfA, N-terminal", "go_ids": [], "go_terms": [], "name": "MtfA_N", "pathway_ids": ["PWY-7694", "PWY-6423", "PWY-7954"], "pathways": ["PWY-7694:t:zwittermicin A biosynthesis", "PWY-6423:t:hemoglobin degradation", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis"], "type": "Homologous_superfamily"}, "IPR042253": {"description": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase superfamily", "go_ids": [], "go_terms": [], "name": "Pglycerate_mutase_ApgM_sf", "pathway_ids": ["PWY-5484", "PWY-8362", "PWY-1042", "PWY-8404", "PWY-2221", "PWY-7124", "PWY-6886", "PWY-6142", "PWY-5723", "PWY-7218", "PWY-7003", "PWY-6901"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "PWY-8362:t:photorespiration II", "PWY-1042:t:glycolysis IV", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-2221:t:Entner-Doudoroff pathway III (semi-phosphorylative)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-6886:t:1-butanol autotrophic biosynthesis (engineered)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-5723:t:Rubisco shunt", "PWY-7218:t:photosynthetic 3-hydroxybutanoate biosynthesis (engineered)", "PWY-7003:t:glycerol degradation to butanol", "PWY-6901:t:superpathway of glucose and xylose degradation"], "type": "Homologous_superfamily"}, "IPR042255": {"description": "Ethanolamine ammonia-lyase light chain, N-terminal", "go_ids": [], "go_terms": [], "name": "EutC_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042257": {"description": "2-keto-3-deoxy-galactonokinase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DGOK_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042258": {"description": "2-keto-3-deoxy-galactonokinase, 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"pathways": ["R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Homologous_superfamily"}, "IPR042264": {"description": "Diphthamide synthesis DPH1/DPH2, domain 2", "go_ids": [], "go_terms": [], "name": "DPH1/DPH2_2", "pathway_ids": ["PWY-7546", "PWY-6482", "R-SPO-5358493", "R-SCE-5358493", "R-MMU-5358493", "R-CEL-5358493", "R-DDI-5358493", "R-HSA-5358493", "R-DRE-5358493"], "pathways": ["PWY-7546:t:diphthamide biosynthesis II (eukaryotes)", "PWY-6482:t:diphthamide biosynthesis I (archaea)", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Homologous_superfamily"}, "IPR042265": {"description": "Diphthamide synthesis DPH1/DPH2, domain 3", "go_ids": [], "go_terms": [], "name": "DPH1/DPH2_3", "pathway_ids": ["R-SPO-5358493", "R-CEL-5358493", "R-SCE-5358493", "R-MMU-5358493", "R-DDI-5358493", "R-HSA-5358493", "R-DRE-5358493"], "pathways": ["R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-DDI-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2", "R-DRE-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Homologous_superfamily"}, "IPR042266": {"description": "PPPDE peptidase domain superfamily", "go_ids": [], "go_terms": [], "name": "PPPDE_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042267": {"description": "VTC domain superfamily", "go_ids": [], "go_terms": [], "name": "VTC_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042268": {"description": "Outer membrane protein assembly factor BamC, C-terminal", "go_ids": [], "go_terms": [], "name": "BamC_C", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Homologous_superfamily"}, "IPR042269": {"description": "Serine carboxypeptidase S28, SKS domain", "go_ids": [], "go_terms": [], "name": "Ser_carbopepase_S28_SKS", "pathway_ids": ["R-MMU-140837", "R-HSA-6798695", "R-MMU-6798695", "R-HSA-140837", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR042270": {"description": "tRNA-dihydrouridine(16) synthase, C-terminal", "go_ids": [], "go_terms": [], "name": "DusC_C", "pathway_ids": ["PWY-6309", "PWY-8382", "PWY-7655", "PWY-5292", "PWY-7096", "PWY-7300", "PWY-8374", "PWY-5956", "PWY-8103", "PWY-6302", "PWY-6996", "PWY-7881", "PWY-6824", "PWY-7154", "PWY-5367", "PWY-8152", "PWY-5984", "PWY-5393", "PWY-5972", "PWY-6944", "PWY-7770", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-6332", "PWY-7846", "PWY-6088", "PWY-7155", "PWY-8044", "PWY-6786", "PWY-7653", "PWY-2541", "PWY-5818", "PWY-7826"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-7096:t:triclosan resistance", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-6996:t:daidzin and daidzein degradation", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-6824:t:justicidin B biosynthesis", "PWY-7154:t:ergosterol biosynthesis II", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-5984:t:rifamycin B biosynthesis", "PWY-5393:t:raspberry ketone biosynthesis", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7770:t:indolmycin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-6332:t:coumestrol biosynthesis", "PWY-7846:t:heme degradation V", "PWY-6088:t:3-chlorobenzoate degradation I (via chlorocatechol)", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-7653:t:griseofulvin biosynthesis", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWY-5818:t:validamycin biosynthesis", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis"], "type": "Homologous_superfamily"}, "IPR042271": {"description": "Zinicin-like metallopeptidase type 2, N-terminal", "go_ids": [], "go_terms": [], "name": "Zinicin_2_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042272": {"description": "ATP12, ATP synthase F1-assembly protein, N-terminal", "go_ids": [], "go_terms": [], "name": "ATP12_ATP_synth-F1-assembly_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042274": {"description": "Regulatory protein YycH/YycI , domain 2", "go_ids": [], "go_terms": [], "name": "YycH/YycI_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042276": {"description": "F-actin-capping protein subunit alpha/beta, domain 2", "go_ids": [], "go_terms": [], "name": "CapZ_alpha/beta_2", "pathway_ids": ["R-HSA-9013405", "R-HSA-2132295", "R-HSA-879415", "R-GGA-879415", "R-BTA-879415", "R-HSA-983231", "R-HSA-6807878", "R-MMU-879415", "R-HSA-8950505", "R-HSA-3371497", "R-SSC-879415", "R-RNO-879415", "R-HSA-9662360", "R-HSA-9035034", "R-HSA-6811436"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-GGA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-BTA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR042277": {"description": "Vacuolar protein sorting-associated protein IST1-like", "go_ids": [], "go_terms": [], "name": "IST1-like", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-SPO-9668328", "R-SPO-6798695", "R-SCE-9668328", "R-MMU-9668328", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-9668328", "R-RNO-6798695", "R-DDI-9668328", "R-RNO-9668328"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SPO-6798695:r:Neutrophil degranulation", "R-SCE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-MMU-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-RNO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III"], "type": "Homologous_superfamily"}, "IPR042278": {"description": "Fimbrillin-like 1, N-terminal", "go_ids": [], "go_terms": [], "name": "Mfa-like_1_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042279": {"description": "Peptidase M60, enhancin-like domain 3", "go_ids": [], "go_terms": [], "name": "Pep_M60_3", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042280": {"description": "Amino acid transporter heavy chain SLC3A2", "go_ids": ["GO:0006865"], "go_terms": ["GO:0006865:amino acid transport:P"], "name": "SLC3A2", "pathway_ids": ["R-HSA-71240", "R-HSA-352230", "R-RNO-352230", "R-RNO-210991", "R-HSA-5660862", "R-MMU-210991", "R-MMU-71240", "R-RNO-71240", "R-HSA-210991", "R-MMU-352230"], "pathways": ["R-HSA-71240:r:Tryptophan catabolism", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-RNO-210991:r:Basigin interactions", "R-HSA-5660862:r:Defective SLC7A7 causes lysinuric protein intolerance (LPI)", "R-MMU-210991:r:Basigin interactions", "R-MMU-71240:r:Tryptophan catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-HSA-210991:r:Basigin interactions", "R-MMU-352230:r:Amino acid transport across the plasma membrane"], "type": "Family"}, "IPR042281": {"description": "GpdQ, beta-strand dimerisation domain", "go_ids": [], "go_terms": [], "name": "GpdQ_beta-strand", "pathway_ids": ["PWY-8051", "PWY-6952"], "pathways": ["PWY-8051:t:anandamide biosynthesis I", "PWY-6952:t:glycerophosphodiester degradation"], "type": "Homologous_superfamily"}, "IPR042282": {"description": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6/shutdown", "go_ids": [], "go_terms": [], "name": "FKBP6/shu", "pathway_ids": ["R-HSA-5601884", "R-HSA-1221632"], "pathways": ["R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-HSA-1221632:r:Meiotic synapsis"], "type": "Family"}, "IPR042283": {"description": "GpdQ, catalytic alpha/beta sandwich domain", "go_ids": [], "go_terms": [], "name": "GpdQ_catalytic", "pathway_ids": ["PWY-8051", "PWY-6952"], "pathways": ["PWY-8051:t:anandamide biosynthesis I", "PWY-6952:t:glycerophosphodiester degradation"], "type": "Homologous_superfamily"}, "IPR042284": {"description": "S-adenosylmethionine decarboxylase, N-terminal", "go_ids": [], "go_terms": [], "name": "AdoMetDC_N", "pathway_ids": ["PWY-6834"], "pathways": ["PWY-6834:t:spermidine biosynthesis III"], "type": "Homologous_superfamily"}, "IPR042285": {"description": "E3 ubiquitin-protein ligase RNF182", "go_ids": [], "go_terms": [], "name": "RNF182", "pathway_ids": ["PWY-7511", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR042286": {"description": "S-adenosylmethionine decarboxylase, C-terminal", "go_ids": [], "go_terms": [], "name": "AdoMetDC_C", "pathway_ids": ["PWY-6834"], "pathways": ["PWY-6834:t:spermidine biosynthesis III"], "type": "Homologous_superfamily"}, "IPR042287": {"description": "FhaA, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "FhaA_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042288": {"description": "Lecithin retinol acyltransferase", "go_ids": ["GO:0047173", "GO:0042572"], "go_terms": ["GO:0047173:phosphatidylcholine-retinol O-acyltransferase activity:F", "GO:0042572:retinol metabolic process:P"], "name": "LRAT", "pathway_ids": ["PWY-6861", "PWY-6857", "R-MMU-975634", "R-MMU-2453902", "R-HSA-9918442", "R-RNO-975634", "R-RNO-2453902", "R-HSA-975634", "R-HSA-2453902"], "pathways": ["PWY-6861:t:the visual cycle I (vertebrates)", "PWY-6857:t:retinol biosynthesis", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9918442:r:Defective visual phototransduction due to LRAT loss of function", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Family"}, "IPR042289": {"description": "Cytochrome c oxidase assembly factor 6 homolog", "go_ids": ["GO:0008535"], "go_terms": ["GO:0008535:respiratory chain complex IV assembly:P"], "name": "COA6", "pathway_ids": ["R-HSA-1268020"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR042292": {"description": "ADP-ribosylation factor-like protein 15", "go_ids": [], "go_terms": [], "name": "ARL15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042293": {"description": "AT-rich interactive domain-containing protein 4", "go_ids": [], "go_terms": [], "name": "ARID4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042294": {"description": "Histone-lysine N-methyltransferase SETD2, animal", "go_ids": ["GO:0046975", "GO:0016279"], "go_terms": ["GO:0046975:histone H3K36 methyltransferase activity:F", "GO:0016279:protein-lysine N-methyltransferase activity:F"], "name": "SETD2_animal", "pathway_ids": ["R-MMU-3214841", "R-HSA-3214841"], "pathways": ["R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines"], "type": "Family"}, "IPR042295": {"description": "NarX-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NarX-like_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042296": {"description": "tRNA methyltransferase, Trm1, C-terminal", "go_ids": [], "go_terms": [], "name": "tRNA_met_Trm1_C", "pathway_ids": ["PWY-6829", "R-HSA-6782315"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Homologous_superfamily"}, "IPR042297": {"description": "Antirestriction domain superfamily", "go_ids": [], "go_terms": [], "name": "Antirestriction_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042298": {"description": "Proto-chlorophyllide reductase, C-terminal", "go_ids": [], "go_terms": [], "name": "P-CP_red_C", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Homologous_superfamily"}, "IPR042299": {"description": "UFD1-like, Nn domain", "go_ids": [], "go_terms": [], "name": "UFD1-like_Nn", "pathway_ids": ["R-DDI-9755511", "R-CEL-9755511", "R-HSA-8951664", "R-HSA-5689880", "R-RNO-9755511", "R-MMU-110320", "R-DME-8951664", "R-DME-110320", "R-SCE-9755511", "R-HSA-9918487", "R-HSA-9755511", "R-MMU-9755511", "R-RNO-110320", "R-SPO-9755511", "R-DDI-8951664", "R-RNO-5689880", "R-DME-9755511", "R-MMU-8951664", "R-MMU-5689880", "R-SCE-8951664", "R-CEL-5689880", "R-CEL-110320", "R-SPO-110320", "R-HSA-9954709", "R-RNO-8951664", "R-SPO-8951664", "R-HSA-110320", "R-DME-5689880", "R-CEL-8951664"], "pathways": ["R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-DME-8951664:r:Neddylation", "R-DME-110320:r:Translesion Synthesis by POLH", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-8951664:r:Neddylation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-8951664:r:Neddylation", "R-CEL-5689880:r:Ub-specific processing proteases", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-8951664:r:Neddylation"], "type": "Homologous_superfamily"}, "IPR042301": {"description": "Glycosyl hydrolase 115 superfamily", "go_ids": [], "go_terms": [], "name": "GH115_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042302": {"description": "Ubiquitin-activating enzyme E1, FCCH domain superfamily", "go_ids": [], "go_terms": [], "name": "E1_FCCH_sf", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-MMU-9909505", "R-HSA-168928", "R-DDI-936440", "R-HSA-9918485", "R-MMU-5656169", "R-RNO-8866652", "R-HSA-936440", "R-HSA-983168", "R-HSA-1169408", "R-MMU-8866652", "R-MMU-1169408", "R-HSA-9909505", "R-DDI-983168", "R-HSA-8866652", "R-DDI-9909505", "R-BTA-8866652", "R-MMU-983168", "R-SPO-983168", "R-RNO-983168", "R-SCE-983168", "R-HSA-5656169", "R-DDI-1169408", "R-DDI-8866652"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-BTA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DDI-1169408:r:ISG15 antiviral mechanism", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "type": "Homologous_superfamily"}, "IPR042303": {"description": "Malonyl-CoA decarboxylase, C-terminal catalytic domain superfamily", "go_ids": [], "go_terms": [], "name": "Malonyl_CoA_deC_C_sf", "pathway_ids": ["PWY-7485", "PWY-8358", "R-RNO-390247", "R-RNO-9033241", "R-MMU-9033241", "R-HSA-9033241", "R-HSA-390247", "R-MMU-390247"], "pathways": ["PWY-7485:t:tetracenomycin C biosynthesis", "PWY-8358:t:curacin A biosynthesis", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Homologous_superfamily"}, "IPR042304": {"description": "Alphavirus E2 glycoprotein, domain A", "go_ids": [], "go_terms": [], "name": "Alphavir_E2_A", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042305": {"description": "Alphavirus E2 glycoprotein, domain B", "go_ids": [], "go_terms": [], "name": "Alphavir_E2_B", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042306": {"description": "Alphavirus E2 glycoprotein, domain C", "go_ids": [], "go_terms": [], "name": "Alphavir_E2_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042307": {"description": "Reeler domain superfamily", "go_ids": [], "go_terms": [], "name": "Reeler_sf", "pathway_ids": ["R-BTA-5173214", "R-RNO-5173214", "R-HSA-8866376", "R-HSA-5173214", "R-MMU-8866376", "R-HSA-5083635", "R-MMU-5173214", "R-RNO-8866376"], "pathways": ["R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-8866376:r:Reelin signalling pathway", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-8866376:r:Reelin signalling pathway", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-RNO-8866376:r:Reelin signalling pathway"], "type": "Homologous_superfamily"}, "IPR042308": {"description": "Helper-component proteinase (HC-Pro) cysteine protease (CPD) domain superfamily", "go_ids": [], "go_terms": [], "name": "HC_PRO_CPD_sf", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR042309": {"description": "Pestivirus envelope glycoprotein E2, domain A", "go_ids": [], "go_terms": [], "name": "Pestivirus_E2_A", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Homologous_superfamily"}, "IPR042310": {"description": "Pestivirus envelope glycoprotein E2, domain B", "go_ids": [], "go_terms": [], "name": "Pestivirus_E2_B", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Homologous_superfamily"}, "IPR042311": {"description": "Pestivirus envelope glycoprotein E2, domain D", "go_ids": [], "go_terms": [], "name": "Pestivirus_E2_D", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Homologous_superfamily"}, "IPR042312": {"description": "Uncharacterized protein F26C11.3-like", "go_ids": [], "go_terms": [], 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"Family"}, "IPR042318": {"description": "Consortin", "go_ids": ["GO:0071253", "GO:0005802"], "go_terms": ["GO:0071253:connexin binding:F", "GO:0005802:trans-Golgi network:C"], "name": "Consortin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042319": {"description": "Glycoprotein integral membrane protein 1", "go_ids": [], "go_terms": [], "name": "GINM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042320": {"description": "Protein MMS22-like", "go_ids": ["GO:0000724", "GO:0031297"], "go_terms": ["GO:0000724:double-strand break repair via homologous recombination:P", "GO:0031297:replication fork processing:P"], "name": "MMS22-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042321": {"description": "Integral inner nuclear membrane protein ima1", "go_ids": ["GO:0071765"], "go_terms": ["GO:0071765:nuclear inner membrane organization:P"], "name": "Ima1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042322": {"description": "Protein 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"R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-BTA-5621480:r:Dectin-2 family", "R-BTA-2871796:r:FCERI mediated 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{"description": "BTB/POZ domain-containing protein 7", "go_ids": ["GO:0061138"], "go_terms": ["GO:0061138:morphogenesis of a branching epithelium:P"], "name": "Btbd7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042349": {"description": "Uncharacterized protein C9orf40-like", "go_ids": [], "go_terms": [], "name": "C9orf40-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042350": {"description": "All-trans retinoic acid-induced differentiation factor", "go_ids": [], "go_terms": [], "name": "ATRAID", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042351": {"description": "Uncharacterized protein C3orf18-like", "go_ids": [], "go_terms": [], "name": "C3orf18-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042352": {"description": "EF-hand calcium-binding domain-containing protein 14", "go_ids": [], "go_terms": [], "name": "EFCAB14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042353": {"description": "Probable 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DNA", "R-HSA-75102:r:C6 deamination of adenosine", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1606322:r:ZBP1(DAI) mediated induction of type I IFNs", "R-RNO-9833482:r:PKR-mediated signaling", "R-MMU-77042:r:Formation of editosomes by ADAR proteins", "R-HSA-77042:r:Formation of editosomes by ADAR proteins"], "type": "Domain"}, "IPR042372": {"description": "Interleukin-15 receptor subunit alpha", "go_ids": ["GO:0042010", "GO:0035723"], "go_terms": ["GO:0042010:interleukin-15 receptor activity:F", "GO:0035723:interleukin-15-mediated signaling pathway:P"], "name": "IL15RA", "pathway_ids": ["R-HSA-8983432", "R-MMU-8983432"], "pathways": ["R-HSA-8983432:r:Interleukin-15 signaling", "R-MMU-8983432:r:Interleukin-15 signaling"], "type": "Family"}, "IPR042373": {"description": "Tumor necrosis factor ligand superfamily member 9", "go_ids": ["GO:0032813"], "go_terms": ["GO:0032813:tumor necrosis factor receptor superfamily binding:F"], "name": "TNFSF9", "pathway_ids": ["R-HSA-5669034", "R-MMU-5669034"], "pathways": ["R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR042374": {"description": "CD70 antigen", "go_ids": ["GO:0005164", "GO:0033209"], "go_terms": ["GO:0005164:tumor necrosis factor receptor binding:F", "GO:0033209:tumor necrosis factor-mediated signaling pathway:P"], "name": "CD70", "pathway_ids": ["R-HSA-5669034", "R-MMU-5669034"], "pathways": ["R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR042375": {"description": "A-kinase anchor protein 5", "go_ids": ["GO:0008179", "GO:0045762", "GO:0005886"], "go_terms": ["GO:0008179:adenylate cyclase binding:F", "GO:0045762:positive regulation of adenylate cyclase activity:P", "GO:0005886:plasma membrane:C"], "name": "AKAP5", "pathway_ids": ["R-RNO-399719", "R-HSA-399719", "R-HSA-9010642", "R-HSA-381676", "R-MMU-399719"], "pathways": ["R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-399719:r:Trafficking of AMPA receptors"], "type": "Family"}, "IPR042376": {"description": "Mediator of RNA polymerase II transcription subunit 26", "go_ids": ["GO:0016592", "GO:0006357"], "go_terms": ["GO:0016592:mediator complex:C", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "MED26", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR042377": {"description": "Gasdermin-E", "go_ids": ["GO:0012501"], "go_terms": ["GO:0012501:programmed cell death:P"], "name": "GSDME", "pathway_ids": ["R-HSA-111457", "R-HSA-9662360", "R-HSA-9662361", "R-MMU-111457", "R-HSA-5620971", "R-MMU-5620971", "R-HSA-5686938", "R-MMU-5686938", "R-HSA-9710421"], "pathways": ["R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-5620971:r:Pyroptosis", "R-MMU-5620971:r:Pyroptosis", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-9710421:r:Defective pyroptosis"], "type": "Family"}, "IPR042378": {"description": "Integral membrane protein DGCR2/IDD", "go_ids": [], "go_terms": [], "name": "IDD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042379": {"description": "Programmed cell death 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"R-MMU-5669034"], "pathways": ["R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR042381": {"description": "T-cell surface protein tactile", "go_ids": [], "go_terms": [], "name": "CD96", "pathway_ids": ["R-RNO-198933", "R-HSA-198933", "R-MMU-198933"], "pathways": ["R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR042383": {"description": "Fibrinogen silencer-binding protein", "go_ids": [], "go_terms": [], "name": "FSBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042384": {"description": "Neuromedin-U", "go_ids": ["GO:0042922"], "go_terms": ["GO:0042922:neuromedin U receptor binding:F"], "name": "NMU", "pathway_ids": ["R-MMU-416476", "R-SSC-375276", "R-HSA-418594", "R-RNO-375276", "R-GGA-418594", "R-HSA-375276", "R-MMU-418594", "R-GGA-416476", "R-SSC-416476", "R-SSC-418594", "R-MMU-375276", "R-HSA-416476", "R-RNO-416476", "R-GGA-375276", "R-RNO-418594"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-GGA-418594:r:G alpha (i) signalling events", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-GGA-416476:r:G alpha (q) signalling events", "R-SSC-416476:r:G alpha (q) signalling events", "R-SSC-418594:r:G alpha (i) signalling events", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-HSA-416476:r:G alpha (q) signalling events", "R-RNO-416476:r:G alpha (q) signalling events", "R-GGA-375276:r:Peptide ligand-binding receptors", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR042385": {"description": "CD160 ANTIGEN", "go_ids": ["GO:0002819", "GO:0004888"], "go_terms": ["GO:0002819:regulation of adaptive immune response:P", "GO:0004888:transmembrane signaling receptor activity:F"], "name": "CD160", "pathway_ids": ["R-HSA-198933", "R-MMU-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR042397": {"description": "Podocalyxin-like protein 2", "go_ids": [], "go_terms": [], "name": "PODXL2", "pathway_ids": ["R-HSA-156584", "R-MMU-156584"], "pathways": ["R-HSA-156584:r:Cytosolic sulfonation of small molecules", "R-MMU-156584:r:Cytosolic sulfonation of small molecules"], "type": "Family"}, "IPR042398": {"description": "Bcl-2-like protein 13", "go_ids": ["GO:0006915"], "go_terms": ["GO:0006915:apoptotic process:P"], "name": "BCL2L13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042401": {"description": "Sperm microtubule associated protein 2-like", "go_ids": [], "go_terms": [], "name": "SPMAP2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042402": {"description": "Epididymal secretory protein E3-alpha/beta", "go_ids": [], "go_terms": [], "name": "EDDM3A/EDDM3B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042403": {"description": "Spt21/Ams2", "go_ids": [], "go_terms": [], "name": "Spt21/Ams2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042404": {"description": "KATNB1-like protein 1", "go_ids": [], "go_terms": [], "name": "KATNBL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042405": {"description": "Protrudin", "go_ids": ["GO:0016192", "GO:0071787", "GO:0072659"], "go_terms": ["GO:0016192:vesicle-mediated transport:P", "GO:0071787:endoplasmic reticulum tubular network formation:P", "GO:0072659:protein localization to plasma membrane:P"], "name": "Protrudin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042406": {"description": "Vitamin K epoxide reductase complex subunit 1", "go_ids": ["GO:0047057", "GO:0042373"], "go_terms": ["GO:0047057:vitamin-K-epoxide reductase (warfarin-sensitive) activity:F", "GO:0042373:vitamin K metabolic process:P"], "name": "VKORC1/VKORC1L1", "pathway_ids": ["PWY-7999", "R-MMU-6806664", "R-BTA-6806664", "R-HSA-6806664", "R-RNO-6806664"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "R-MMU-6806664:r:Metabolism of vitamin K", "R-BTA-6806664:r:Metabolism of vitamin K", "R-HSA-6806664:r:Metabolism of vitamin K", "R-RNO-6806664:r:Metabolism of vitamin K"], "type": "Family"}, "IPR042407": {"description": "Protein NCBP2AS2", "go_ids": [], "go_terms": [], "name": "NCBP2-AS2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042410": {"description": "Transducin beta-like protein 2", "go_ids": [], "go_terms": [], "name": "WBSCR13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042411": {"description": "WD repeat-containing protein 27", "go_ids": [], "go_terms": [], "name": "WDR27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042412": {"description": "Homeobox protein prophet of Pit-1", "go_ids": ["GO:0021983", "GO:0000981"], "go_terms": ["GO:0021983:pituitary gland development:P", "GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific:F"], "name": "PROP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042414": {"description": "T-cell surface glycoprotein CD8 beta chain", "go_ids": ["GO:0042288", "GO:0050776", "GO:0015026"], "go_terms": ["GO:0042288:MHC class I protein binding:F", "GO:0050776:regulation of immune response:P", "GO:0015026:coreceptor activity:F"], "name": "CD8B", "pathway_ids": ["R-RNO-198933", "R-HSA-198933", "R-MMU-198933", "R-HSA-182218"], "pathways": ["R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a 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"R-DRE-5696394", "R-DME-5696394", "R-DME-201722", "R-RNO-5696394", "R-RNO-5689880", "R-HSA-171319", "R-CEL-5689880", "R-MMU-5689880", "R-RNO-5689603", "R-DRE-5689603", "R-HSA-201722", "R-DME-5689603", "R-HSA-5696394", "R-MMU-5696394", "R-MMU-5689603", "R-HSA-3214847", "R-HSA-5689603", "R-DME-5689880"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-5689603:r:UCH proteinases", "R-DRE-5689603:r:UCH proteinases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DME-5689603:r:UCH proteinases", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5689603:r:UCH proteinases", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-DME-5689880:r:Ub-specific processing proteases"], "type": "Homologous_superfamily"}, "IPR042488": {"description": "Rad4, beta-hairpin domain 3 superfamily", "go_ids": [], "go_terms": [], "name": "Rad4_BHD3_sf", "pathway_ids": ["R-SCE-3108214", "R-MMU-5696395", "R-SPO-5696395", "R-SPO-3108214", "R-HSA-3108214", "R-HSA-5696395", "R-HSA-5696394", "R-SPO-5696394", "R-MMU-5696394", "R-MMU-3108214", "R-DME-5696395", "R-DME-5696394"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Homologous_superfamily"}, "IPR042489": {"description": "F-actin capping protein, alpha subunit, domain 1", "go_ids": [], "go_terms": 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stimulation", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-SSC-879415:r:Advanced glycosylation endproduct receptor signaling"], "type": "Homologous_superfamily"}, "IPR042490": {"description": "Acyl-CoA thioester hydrolase/BAAT, N-terminal", "go_ids": [], "go_terms": [], "name": "Thio_Ohase/BAAT_N", "pathway_ids": ["PWY-7723", "PWY-6733", "PWY-1121", "PWY-321", "PWY-5996", "PWY-5972", "R-MMU-9837999", "R-MMU-193368", "R-HSA-9918432", "R-HSA-193368", "R-MMU-9033241", "R-RNO-9837999", "R-RNO-9033241", "R-MMU-159418", "R-RNO-159418", "R-RNO-77289", "R-HSA-390247", "R-MMU-77289", "R-RNO-193368", "R-MMU-390247", "R-HSA-159418", "R-HSA-9837999", "R-HSA-9033241", "R-HSA-77289"], "pathways": ["PWY-7723:t:bacterial bioluminescence", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-1121:t:suberin monomers biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-5996:t:oleate biosynthesis II (animals and fungi)", "PWY-5972:t:stearate biosynthesis I (animals)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-9918432:r:Maturation of DENV proteins", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-159418:r:Recycling of bile acids and salts", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation"], "type": "Homologous_superfamily"}, "IPR042491": {"description": "Vacuolar protein sorting-associated protein 35, C-terminal", "go_ids": [], "go_terms": [], "name": "Vps35_C", "pathway_ids": ["R-BTA-3238698", "R-MMU-3238698", "R-SCE-3238698", "R-DDI-3238698", "R-SPO-3238698", "R-HSA-3238698"], "pathways": ["R-BTA-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-SCE-3238698:r:WNT ligand biogenesis and trafficking", "R-DDI-3238698:r:WNT ligand biogenesis and trafficking", "R-SPO-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking"], "type": "Homologous_superfamily"}, "IPR042493": {"description": "Bacterial type XPD DNA helicase, FeS cluster domain", "go_ids": [], "go_terms": [], "name": "XPD_DNA_FeS", 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"go_terms": [], "name": "TBC1D19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042508": {"description": "F-box/WD repeat-containing protein 5", "go_ids": ["GO:0080008", "GO:0016567", "GO:0019005"], "go_terms": ["GO:0080008:Cul4-RING E3 ubiquitin ligase complex:C", "GO:0016567:protein ubiquitination:P", "GO:0019005:SCF ubiquitin ligase complex:C"], "name": "FBXW5", "pathway_ids": ["R-MMU-8951664", "R-HSA-983168", "R-RNO-983168", "R-HSA-390471", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR042509": {"description": "Zinc finger CCHC domain-containing protein 3", "go_ids": ["GO:0002218", "GO:0003723", "GO:0003690"], "go_terms": ["GO:0002218:activation of innate immune response:P", "GO:0003723:RNA binding:F", "GO:0003690:double-stranded DNA binding:F"], "name": "ZCCHC3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042510": {"description": "Protein CIP2A", "go_ids": [], "go_terms": [], "name": "CIP2A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042511": {"description": "DNA replication regulator Sld3", "go_ids": ["GO:0006270"], "go_terms": ["GO:0006270:DNA replication initiation:P"], "name": "Sld3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042512": {"description": "TLC domain-containing protein 5", "go_ids": [], "go_terms": [], "name": "TLCD5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042515": {"description": "Non-structural protein NSP15, N-terminal domain superfamily, coronavirus", "go_ids": [], "go_terms": [], "name": "NSP15_N_CoV", "pathway_ids": 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"R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR042516": {"description": "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Prp8_U5-snRNA-bd_sf", "pathway_ids": ["R-HSA-72163", "R-CEL-72165", "R-MMU-72165", "R-MMU-72163", "R-HSA-72165", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Homologous_superfamily"}, "IPR042517": {"description": "Beta-1,3-glucanase, N-terminal, subdomain 2", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_64_N_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042518": {"description": "Precorrin-2 dehydrogenase, C-terminal helical domain", "go_ids": [], "go_terms": [], "name": "SirC_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042519": {"description": "Non-structural protein NSP3, N-terminal, rotavirus", "go_ids": [], "go_terms": [], "name": "NSP3_N_rotavirus", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042520": {"description": "Glutamate--cysteine ligase GshA, N-terminal", "go_ids": [], "go_terms": [], "name": "GshA_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042521": {"description": "Dual specificity tyrosine-phosphorylation-regulated kinase", "go_ids": ["GO:0004712"], "go_terms": ["GO:0004712:protein serine/threonine/tyrosine kinase activity:F"], "name": "DYRK", "pathway_ids": ["R-MMU-6804756", "R-GGA-6804756", "R-HSA-6804756", "R-SPO-6804756", "R-DME-6804756", "R-DDI-6804756"], "pathways": ["R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-GGA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation"], "type": "Homologous_superfamily"}, "IPR042522": {"description": "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1", "go_ids": [], "go_terms": [], "name": "Atg7_N_1", "pathway_ids": ["R-HSA-6798695", "R-GGA-983168", "R-SPO-6798695", "R-DDI-6798695", "R-DDI-1632852", "R-GGA-1632852", "R-HSA-6802952", "R-MMU-1632852", "R-HSA-9918485", "R-SCE-6798695", "R-HSA-983168", "R-GGA-6798695", "R-DDI-983168", "R-SCE-1632852", "R-RNO-1632852", "R-HSA-1632852", "R-MMU-983168", "R-MMU-6798695", "R-RNO-983168", "R-SPO-1632852", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-1632852:r:Macroautophagy", "R-GGA-1632852:r:Macroautophagy", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-1632852:r:Macroautophagy", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-6798695:r:Neutrophil degranulation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-1632852:r:Macroautophagy", "R-RNO-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-1632852:r:Macroautophagy", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR042523": {"description": "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2", "go_ids": [], "go_terms": [], "name": "Atg7_N_2", "pathway_ids": ["R-HSA-6798695", "R-GGA-983168", "R-SPO-6798695", "R-DDI-6798695", "R-DDI-1632852", "R-GGA-1632852", "R-HSA-6802952", "R-MMU-1632852", "R-HSA-9918485", "R-SCE-6798695", "R-HSA-983168", "R-GGA-6798695", "R-DDI-983168", "R-SCE-1632852", "R-RNO-1632852", "R-HSA-1632852", "R-MMU-983168", "R-MMU-6798695", "R-RNO-983168", "R-SPO-1632852", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-1632852:r:Macroautophagy", "R-GGA-1632852:r:Macroautophagy", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-1632852:r:Macroautophagy", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-6798695:r:Neutrophil degranulation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-1632852:r:Macroautophagy", "R-RNO-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-1632852:r:Macroautophagy", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR042524": {"description": "Presenilin, C-terminal", "go_ids": [], "go_terms": [], "name": "Presenilin_C", "pathway_ids": ["R-HSA-6798695", "R-MMU-9839383", "R-SSC-1251985", "R-HSA-2122948", "R-MMU-3928665", "R-RNO-9017802", "R-CEL-6798695", "R-HSA-1251985", "R-SSC-193692", "R-BTA-9839383", "R-BTA-6798695", "R-DRE-193692", "R-RNO-193692", "R-CEL-1251985", "R-HSA-9017802", "R-MMU-193692", "R-DRE-9839383", "R-HSA-2979096", "R-HSA-9013700", "R-MMU-9013507", "R-DRE-6798695", "R-RNO-3928665", "R-BTA-1251985", "R-RNO-205043", "R-DME-3928665", "R-HSA-9013507", "R-DME-1251985", "R-MMU-205043", "R-RNO-1251985", "R-HSA-1474228", "R-DDI-6798695", "R-DME-6798695", "R-HSA-205043", "R-HSA-2894862", "R-RNO-9839383", "R-RNO-9013507", "R-HSA-9839383", "R-MMU-9017802", "R-CEL-3928665", "R-MMU-1251985", "R-SSC-9839383", "R-BTA-193692", "R-HSA-3928665", "R-SSC-3928665", "R-MMU-6798695", "R-DRE-3928665", "R-HSA-2644606", "R-BTA-3928665", "R-DRE-1251985", "R-BTA-205043", "R-HSA-193692", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-SSC-1251985:r:Nuclear signaling by ERBB4", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-SSC-193692:r:Regulated proteolysis of p75NTR", "R-BTA-9839383:r:TGFBR3 PTM regulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DRE-193692:r:Regulated proteolysis of p75NTR", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-DRE-9839383:r:TGFBR3 PTM regulation", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-SSC-9839383:r:TGFBR3 PTM regulation", "R-BTA-193692:r:Regulated proteolysis of p75NTR", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR042525": {"description": "DNA repair protein Rad52/59/22 superfamily", "go_ids": [], "go_terms": [], "name": "Rad52_Rad59_Rad22_sf", "pathway_ids": ["R-SCE-3108214", "R-SCE-5685938", "R-MMU-5685938", "R-GGA-5685938", "R-SPO-3108214", "R-GGA-3108214", "R-HSA-3108214", "R-SPO-5685938", "R-MMU-5685939", "R-GGA-5685939", "R-MMU-3108214", "R-HSA-5685939", "R-HSA-5685938"], "pathways": ["R-SCE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SCE-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-GGA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-GGA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-GGA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Homologous_superfamily"}, "IPR042526": {"description": "Autophagy protein Atg5, helix rich domain", "go_ids": [], "go_terms": [], "name": "Atg5_HR", "pathway_ids": ["R-HSA-8934903", "R-DDI-1632852", "R-MMU-8934903", "R-RNO-8934903", "R-RNO-5205685", "R-CEL-8934903", "R-BTA-5205685", "R-CEL-1632852", "R-MMU-1632852", "R-HSA-936440", "R-CEL-5205685", "R-MMU-5205685", "R-BTA-1632852", "R-SCE-1632852", "R-SPO-8934903", "R-RNO-1632852", "R-BTA-8934903", "R-SCE-8934903", "R-HSA-1632852", "R-DME-1632852", "R-HSA-5205685", "R-SPO-1632852"], "pathways": ["R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DDI-1632852:r:Macroautophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-1632852:r:Macroautophagy", "R-SCE-1632852:r:Macroautophagy", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-1632852:r:Macroautophagy", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-1632852:r:Macroautophagy"], "type": "Homologous_superfamily"}, "IPR042527": {"description": "Autophagy protein Atg5, UblA domain superfamily", "go_ids": [], "go_terms": [], "name": "Atg5_UblA_dom_sf", "pathway_ids": ["R-HSA-8934903", "R-DDI-1632852", "R-MMU-8934903", "R-RNO-8934903", "R-RNO-5205685", "R-CEL-8934903", "R-BTA-5205685", "R-CEL-1632852", "R-MMU-1632852", "R-HSA-936440", "R-CEL-5205685", "R-MMU-5205685", "R-BTA-1632852", "R-SCE-1632852", "R-SPO-8934903", "R-RNO-1632852", "R-BTA-8934903", "R-SCE-8934903", "R-HSA-1632852", "R-DME-1632852", "R-HSA-5205685", "R-SPO-1632852"], "pathways": ["R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DDI-1632852:r:Macroautophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-1632852:r:Macroautophagy", "R-SCE-1632852:r:Macroautophagy", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-1632852:r:Macroautophagy", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-1632852:r:Macroautophagy"], "type": "Homologous_superfamily"}, "IPR042528": {"description": "Translation initiation factor eIF-2B subunit alpha, N-terminal", "go_ids": [], "go_terms": [], "name": "elF-2B_alpha_N", "pathway_ids": ["R-SCE-72731", "R-HSA-72731", "R-BTA-72731", "R-RNO-72731", "R-CEL-72731", "R-MMU-72731", "R-SPO-72731", "R-DDI-72731"], "pathways": ["R-SCE-72731:r:Recycling of eIF2:GDP", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-CEL-72731:r:Recycling of eIF2:GDP", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-DDI-72731:r:Recycling of eIF2:GDP"], "type": "Homologous_superfamily"}, "IPR042529": {"description": "Initiation factor 2B-like, C-terminal", "go_ids": [], "go_terms": [], "name": "IF_2B-like_C", "pathway_ids": ["PWY-7174", "PWY-8130", "PWY-8132", "PWY-8131", "PWY-4361", "R-DRE-1237112", "R-SCE-72731", "R-HSA-72731", "R-MMU-72731", "R-CEL-72731", "R-SPO-1237112", "R-RNO-1237112", "R-DDI-72731", "R-SPO-72731", "R-MMU-1237112", "R-BTA-72731", "R-XTR-1237112", "R-RNO-72731", "R-CEL-1237112", "R-DME-1237112", "R-HSA-1237112"], "pathways": ["PWY-7174:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II", "PWY-8130:t:5'-deoxyadenosine degradation I", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8131:t:5'-deoxyadenosine degradation II", "PWY-4361:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I", "R-DRE-1237112:r:Methionine salvage pathway", "R-SCE-72731:r:Recycling of eIF2:GDP", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-CEL-72731:r:Recycling of eIF2:GDP", "R-SPO-1237112:r:Methionine salvage pathway", "R-RNO-1237112:r:Methionine salvage pathway", "R-DDI-72731:r:Recycling of eIF2:GDP", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-MMU-1237112:r:Methionine salvage pathway", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-XTR-1237112:r:Methionine salvage pathway", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-CEL-1237112:r:Methionine salvage pathway", "R-DME-1237112:r:Methionine salvage pathway", "R-HSA-1237112:r:Methionine salvage pathway"], "type": "Homologous_superfamily"}, "IPR042530": {"description": "EME1/EME2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "EME1/EME2_C", "pathway_ids": ["R-DRE-5693568", "R-XTR-5693568", "R-SCE-5693568", "R-DRE-6783310", "R-SPO-5693568", "R-RNO-5693568", "R-MMU-5693568", "R-HSA-5693568", "R-HSA-6783310", "R-RNO-6783310", "R-MMU-6783310"], "pathways": ["R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-XTR-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SCE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-SPO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Homologous_superfamily"}, "IPR042531": {"description": "Phospholipase C-beta, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PLC-beta_C_sf", "pathway_ids": ["PWY-6367", "PWY-7039", "PWY-6351", "PWY-8052", "R-MMU-416476", "R-BTA-112043", "R-MMU-4086398", "R-HSA-416476", "R-HSA-399997", "R-CEL-416476", "R-RNO-399997", "R-HSA-112043", "R-HSA-500657", "R-BTA-4086398", "R-DME-1855204", "R-DME-416476", "R-HSA-4086398", "R-MMU-434316", "R-MMU-1855204", "R-RNO-416476", "R-RNO-434316", "R-CEL-1855204", "R-HSA-434316", "R-HSA-418217", "R-MMU-112043", "R-MMU-500657", "R-BTA-434316", "R-BTA-399997", "R-RNO-112043", "R-BTA-500657", "R-BTA-416476", "R-BTA-1855204", "R-HSA-9717207", "R-MMU-418217", "R-CEL-112043", "R-DME-112043", "R-HSA-1855204", "R-MMU-399997", "R-RNO-1855204", "R-BTA-418217"], "pathways": ["PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "R-MMU-416476:r:G alpha (q) signalling events", "R-BTA-112043:r:PLC beta mediated events", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-CEL-416476:r:G alpha (q) signalling events", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-112043:r:PLC beta mediated events", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-4086398:r:Ca2+ pathway", "R-DME-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-MMU-112043:r:PLC beta mediated events", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-BTA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-BTA-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-112043:r:PLC beta mediated events", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-416476:r:G alpha (q) signalling events", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-CEL-112043:r:PLC beta mediated events", "R-DME-112043:r:PLC beta mediated events", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-418217:r:G beta:gamma signalling through PLC beta"], "type": "Homologous_superfamily"}, "IPR042532": {"description": "Exocyst complex component EXOC3/Sec6, C-terminal domain", "go_ids": [], "go_terms": [], "name": "EXOC3/Sec6_C", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-BTA-5620916", "R-RNO-5620916", "R-HSA-1445148", "R-MMU-264876", "R-HSA-264876", "R-CEL-5620916", "R-BTA-264876", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-264876:r:Insulin processing", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-264876:r:Insulin processing", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Homologous_superfamily"}, "IPR042533": {"description": "Nucleoporin, Nup155-like, C-terminal, subdomain 1", "go_ids": [], "go_terms": [], "name": "Nucleoporin_Nup155_C_1", "pathway_ids": ["R-HSA-180910", "R-RNO-9615933", "R-RNO-3301854", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-9615933", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-HSA-3371453", "R-RNO-191859", "R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-DME-3371453", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-DME-159227", "R-HSA-168325", "R-MMU-170822", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-RNO-4085377", "R-SPO-4570464", "R-HSA-5619107", "R-RNO-4570464", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-SPO-159227", "R-SPO-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-HSA-168333", "R-MMU-4085377", "R-HSA-165054", "R-RNO-159236", "R-HSA-4615885", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-DME-4551638", "R-HSA-4085377", "R-RNO-159227", "R-RNO-4551638", "R-DME-159230", "R-DME-3301854", "R-RNO-170822", "R-RNO-159231", "R-HSA-180746"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-191859:r:snRNP Assembly", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Homologous_superfamily"}, "IPR042534": {"description": "Sin3 associated polypeptide p18 superfamily", "go_ids": [], "go_terms": [], "name": "SAP18_sf", "pathway_ids": ["R-HSA-72163", "R-SPO-3214815", "R-MMU-72163", "R-HSA-427413", "R-MMU-3214815", "R-DME-72163", "R-HSA-3214815", "R-HSA-9679191", "R-CEL-72163", "R-DME-3214815"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-3214815:r:HDACs deacetylate histones", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-3214815:r:HDACs deacetylate histones", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DME-3214815:r:HDACs deacetylate histones"], "type": "Homologous_superfamily"}, "IPR042536": {"description": "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily", "go_ids": [], "go_terms": [], "name": "TFIIIC_tauA_Sfc1", "pathway_ids": ["R-SCE-76066", "R-DDI-76066", "R-DDI-76061", "R-SPO-76066", "R-HSA-76066", "R-MMU-76061", "R-HSA-76061", "R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Homologous_superfamily"}, "IPR042537": {"description": "Nucleoporin, Nup155-like, C-terminal, subdomain 2", "go_ids": [], "go_terms": [], "name": "Nucleoporin_Nup155_C_2", "pathway_ids": ["R-HSA-180910", "R-RNO-9615933", "R-RNO-3301854", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-9615933", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-HSA-3371453", "R-RNO-191859", "R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-DME-3371453", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-DME-159227", "R-HSA-168325", "R-MMU-170822", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-RNO-4085377", "R-SPO-4570464", "R-HSA-5619107", "R-RNO-4570464", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-SPO-159227", "R-SPO-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-HSA-168333", "R-MMU-4085377", "R-HSA-165054", "R-RNO-159236", "R-HSA-4615885", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-DME-4551638", "R-HSA-4085377", "R-RNO-159227", "R-RNO-4551638", "R-DME-159230", "R-DME-3301854", "R-RNO-170822", "R-RNO-159231", "R-HSA-180746"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", 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"R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Homologous_superfamily"}, "IPR042538": {"description": "Nucleoporin, Nup155-like, C-terminal, subdomain 3", "go_ids": [], "go_terms": [], "name": "Nucleoporin_Nup155_C_3", "pathway_ids": ["R-HSA-180910", "R-RNO-9615933", "R-RNO-3301854", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-9615933", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-HSA-3371453", "R-RNO-191859", "R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-DME-3371453", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-DME-159227", "R-HSA-168325", "R-MMU-170822", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-9615933", "R-MMU-159227", "R-HSA-9615933", "R-RNO-4085377", "R-SPO-4570464", "R-HSA-5619107", "R-RNO-4570464", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-SPO-159227", "R-SPO-159231", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-HSA-168333", "R-MMU-4085377", "R-HSA-165054", "R-RNO-159236", "R-HSA-4615885", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-168276", "R-HSA-168271", "R-SPO-4551638", "R-DME-4551638", "R-HSA-4085377", "R-RNO-159227", "R-RNO-4551638", "R-DME-159230", "R-DME-3301854", "R-RNO-170822", "R-RNO-159231", "R-HSA-180746"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-191859:r:snRNP Assembly", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Homologous_superfamily"}, "IPR042539": {"description": "Viral matrix protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Matrix_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042540": {"description": "Viral matrix protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Matrix_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042541": {"description": "BART domain superfamily", "go_ids": [], "go_terms": [], "name": "BART_sf", "pathway_ids": ["R-DRE-83936", "R-XTR-83936", "R-HSA-83936", "R-BTA-83936", "R-RNO-83936", "R-MMU-83936"], "pathways": ["R-DRE-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-XTR-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-BTA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "type": "Homologous_superfamily"}, "IPR042542": {"description": "Peptidase C53, pestivirus Npro, interaction domain", "go_ids": [], "go_terms": [], "name": "Peptidase_C53_interaction", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Homologous_superfamily"}, "IPR042543": {"description": "S-adenosylmethionine synthetase, domain 2", "go_ids": [], "go_terms": [], "name": "AdoMet_synthase_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042544": {"description": "S-adenosylmethionine synthetase, domain 3", "go_ids": [], "go_terms": [], "name": "AdoMet_synthase_3", "pathway_ids": ["PWY-5912", "PWY-6151", "PWY-5041"], "pathways": ["PWY-5912:t:2'-deoxymugineic acid phytosiderophore biosynthesis", "PWY-6151:t:S-adenosyl-L-methionine salvage I", "PWY-5041:t:S-adenosyl-L-methionine salvage II"], "type": "Homologous_superfamily"}, "IPR042553": {"description": "TSC22 domain family protein 4", "go_ids": [], "go_terms": [], "name": "TSC22D4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042555": {"description": "StAR-related lipid transfer protein 4", "go_ids": ["GO:0015485", "GO:0032367"], "go_terms": ["GO:0015485:cholesterol binding:F", "GO:0032367:intracellular cholesterol transport:P"], "name": "StarD4", "pathway_ids": ["R-MMU-196108", "R-HSA-196108"], "pathways": ["R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-196108:r:Pregnenolone biosynthesis"], "type": "Family"}, "IPR042556": {"description": "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "AZUL_sf", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Homologous_superfamily"}, "IPR042557": {"description": "SCO4226, nickel-binding ferredoxin-like monomer", "go_ids": [], "go_terms": [], "name": "SCO4226", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042558": {"description": "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1", "go_ids": [], "go_terms": [], "name": "Gln-tRNA-synth_Ib_RNA-bd_N_1", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-RNO-9856649", "R-DME-9856649", "R-HSA-9856649", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR042559": {"description": "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2", "go_ids": [], "go_terms": [], "name": "Gln-tRNA-synth_Ib_RNA-bd_N_2", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-RNO-9856649", "R-DME-9856649", "R-HSA-9856649", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Homologous_superfamily"}, "IPR042560": {"description": "Exocyst component Exo84, C-terminal, subdomain 2", "go_ids": [], "go_terms": [], "name": "Exo84_C_2", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-MMU-5620916", "R-BTA-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-BTA-264876", "R-DDI-264876", "R-SCE-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-BTA-264876:r:Insulin processing", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing"], "type": "Homologous_superfamily"}, "IPR042561": {"description": "Exocyst component Exo84, C-terminal, subdomain 1", "go_ids": [], "go_terms": [], "name": "Exo84_C_1", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-MMU-5620916", "R-BTA-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-BTA-264876", "R-DDI-264876", "R-SCE-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-BTA-264876:r:Insulin processing", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing"], "type": "Homologous_superfamily"}, "IPR042563": {"description": "Small ribosomal subunit protein eS8 subdomain, eukaryota", "go_ids": [], "go_terms": [], "name": "Ribosomal_protein_eS8_euk", "pathway_ids": ["R-BTA-975957", "R-HSA-9010553", "R-SPO-9954714", "R-DME-6791226", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-HSA-72695", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-DME-72706", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-BTA-72695", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-SPO-975956", "R-MMU-9954714", "R-RNO-156827", "R-BTA-6791226", "R-SPO-72706", "R-SCE-975956", "R-DDI-72695", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-RNO-6791226", "R-RNO-72649", "R-HSA-6791226", "R-RNO-975956", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-DDI-72702", "R-DDI-72689", "R-MMU-1799339", "R-SPO-72689", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-DME-72649", "R-RNO-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-SCE-156827", "R-MMU-72702", "R-DME-72695", "R-DME-975956", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-HSA-9754678", "R-HSA-72649", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-SPO-6791226", "R-SCE-72649", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-DDI-9954716", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome 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cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR042564": {"description": "CRISPR-associated endoribonuclease Cas6/Csy4, subtype I-F/YPEST superfamily", "go_ids": [], "go_terms": [], "name": "CRISPR-Cas6/Csy4_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042565": {"description": "Type VII secretion system EssB, C-terminal", "go_ids": [], "go_terms": [], "name": "T7SS_EssB_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042566": {"description": "L1 transposable element, C-terminal domain", "go_ids": [], "go_terms": [], "name": "L1_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042567": {"description": "Spindlin/spermiogenesis-specific domain superfamily", "go_ids": [], "go_terms": [], "name": "SPIN/Ssty_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042568": {"description": "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily", "go_ids": [], "go_terms": [], "name": "QSOX_FAD-bd_sf", "pathway_ids": ["PWY-7533", "R-RNO-381426", "R-HSA-6798695", "R-HSA-114608", "R-RNO-8957275", "R-MMU-381426", "R-MMU-6798695", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR042569": {"description": "Ribosome-associated complex head domain superfamily", "go_ids": [], "go_terms": [], "name": "RAC_head_sf", "pathway_ids": ["R-SCE-3371453", "R-XTR-3371453", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-DRE-3371453", "R-BTA-3371453", "R-MMU-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Homologous_superfamily"}, "IPR042570": {"description": "Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirus", "go_ids": ["GO:0003676"], "go_terms": ["GO:0003676:nucleic acid binding:F"], "name": "NSP3_NAB_bCoV_sf", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 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"R-MMU-9033241", "R-XTR-200425", "R-BTA-389887", "R-HSA-9033241"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-200425:r:Carnitine shuttle", "R-MMU-200425:r:Carnitine shuttle", "R-DRE-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-9033241:r:Peroxisomal protein import", "R-XTR-200425:r:Carnitine shuttle", "R-BTA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Homologous_superfamily"}, "IPR042573": {"description": "GNAT acetyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "GNAT_acetyltra_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR042574": {"description": "Alpha-(1,3)-fucosyltransferase FucT, 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{"description": "TRAF3-interacting protein 1, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "TRAF3IP1_N_sf", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Homologous_superfamily"}, "IPR042616": {"description": "Proline and serine-rich protein 1", "go_ids": [], "go_terms": [], "name": "PROSER1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042617": {"description": "CST complex subunit CTC1-like", "go_ids": [], "go_terms": [], "name": "CTC1-like", "pathway_ids": ["R-MMU-174430", "R-DRE-174430", "R-MMU-174411", "R-HSA-174411", "R-HSA-174430"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174430:r:Telomere C-strand synthesis initiation"], "type": "Family"}, "IPR042618": {"description": "Dynein regulatory complex protein 9", "go_ids": [], "go_terms": [], "name": "IQCG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042619": {"description": "BBSome complex assembly protein BBS10", "go_ids": ["GO:0051131"], "go_terms": ["GO:0051131:chaperone-mediated protein complex assembly:P"], "name": "BBS10", "pathway_ids": ["R-MMU-5620922", "R-HSA-5620922"], "pathways": ["R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Family"}, "IPR042620": {"description": "Protein NSUN7", "go_ids": [], "go_terms": [], "name": "NSUN7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042621": {"description": "Tetratricopeptide repeat protein TTC23/TTC23L", "go_ids": [], "go_terms": [], "name": "TTC23/TTC23L", "pathway_ids": [], "pathways": [], "type": 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the vascular wall", "R-DRE-216083:r:Integrin cell surface interactions", "R-MMU-216083:r:Integrin cell surface interactions"], "type": "Family"}, "IPR042626": {"description": "THO complex subunit 6", "go_ids": [], "go_terms": [], "name": "THOC6", "pathway_ids": ["R-RNO-73856", "R-DRE-159236", "R-DRE-73856", "R-MMU-72187", "R-MMU-73856", "R-RNO-159236", "R-HSA-73856", "R-HSA-159236", "R-HSA-72187", "R-DME-159236", "R-DME-73856", "R-MMU-159236"], "pathways": ["R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing 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processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR042633": {"description": "Quinone oxidoreductase-like protein 1", "go_ids": [], "go_terms": [], "name": "CRYZL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042634": {"description": "Homeobox protein MOX-1/MOX-2", "go_ids": ["GO:0003700", "GO:0045944"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0045944:positive regulation of transcription by RNA polymerase II:P"], "name": "MOX-1/MOX-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042635": {"description": "MEGF10/SREC1/2-like", "go_ids": ["GO:0005044"], "go_terms": ["GO:0005044:scavenger receptor activity:F"], "name": "MEGF10/SREC1/2-like", "pathway_ids": ["R-HSA-3000484", "R-MMU-3000157", "R-MMU-8874081", "R-DME-381426", "R-MMU-9913351", "R-DME-8957275", "R-MMU-381426", "R-CEL-381426", "R-CEL-8957275", "R-DME-446107", "R-MMU-8957275", "R-MMU-446107"], "pathways": ["R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-3000157:r:Laminin interactions", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-446107:r:Type I hemidesmosome assembly"], "type": "Family"}, "IPR042636": {"description": "Ankyrin repeat domain-containing protein 11", "go_ids": [], "go_terms": [], "name": "ANKRD11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042637": {"description": "Ankyrin repeat domain-containing protein AN34A/B/C", "go_ids": [], "go_terms": [], "name": "AN34A/B/C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042651": {"description": "Regulator of G-protein signaling 22", "go_ids": ["GO:0001965", "GO:0009966"], "go_terms": ["GO:0001965:G-protein alpha-subunit binding:F", "GO:0009966:regulation of signal transduction:P"], "name": "Rgs22", "pathway_ids": ["R-HSA-418594"], "pathways": ["R-HSA-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR042652": {"description": "CDK2-associated and cullin domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "CACUL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042653": {"description": "Leukocyte receptor cluster member 9", "go_ids": [], "go_terms": [], "name": "Leng9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042655": {"description": "Leucine-rich repeat-containing protein 72", "go_ids": [], "go_terms": [], "name": "LRC72", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042755": {"description": "E3 ubiquitin-protein ligase COP1", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "COP1", "pathway_ids": ["PWY-7511", "R-MMU-8951664", "R-MMU-349425", "R-HSA-8951664", "R-HSA-349425"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-8951664:r:Neddylation", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-8951664:r:Neddylation", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1"], "type": "Family"}, "IPR042756": {"description": "Protein sel-1 homolog 3", "go_ids": [], "go_terms": [], "name": "Sel-1L3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042757": {"description": "Endothelial cell-selective adhesion molecule", "go_ids": ["GO:0098609"], "go_terms": ["GO:0098609:cell-cell adhesion:P"], "name": "ESAM", "pathway_ids": ["R-RNO-202733", "R-MMU-202733", "R-HSA-202733"], "pathways": ["R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR042758": {"description": "Immunoglobulin superfamily member 11", "go_ids": [], "go_terms": [], "name": "IGSF11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042759": {"description": "Coiled-coil domain-containing protein 126", "go_ids": [], "go_terms": [], "name": "CCDC126", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042768": {"description": "Homeobox protein MNX1/Ceh-12", "go_ids": ["GO:0021520"], "go_terms": ["GO:0021520:spinal cord motor neuron cell fate specification:P"], "name": "MNX1/Ceh-12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042769": {"description": "SPATA6 family", "go_ids": ["GO:0120212", "GO:0007283", "GO:0032027"], "go_terms": ["GO:0120212:sperm head-tail coupling apparatus:C", "GO:0007283:spermatogenesis:P", "GO:0032027:myosin light chain binding:F"], "name": "SPATA6_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042770": {"description": "RWD domain-containing protein 4", "go_ids": [], "go_terms": [], "name": "RWDD4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042771": {"description": "TFIIIC subunit GTF3C6-like", "go_ids": ["GO:0006383"], "go_terms": ["GO:0006383:transcription by RNA polymerase III:P"], "name": "GTF3C6-like", "pathway_ids": ["R-MMU-76061", "R-MMU-76066", "R-HSA-749476", "R-HSA-76066", "R-HSA-76061"], "pathways": ["R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR042772": {"description": "SH3 domain and tetratricopeptide repeat-containing protein SH3TC1/SH3TC2", "go_ids": [], "go_terms": [], "name": "SH3TC1/SH3TC2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042776": {"description": "Large ribosomal subunit protein mL53, fungi", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL53_fung", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042777": {"description": "tRNA-splicing endonuclease subunit Sen15, fungi", "go_ids": ["GO:0000379", "GO:0000214"], "go_terms": ["GO:0000379:tRNA-type intron splice site recognition and cleavage:P", "GO:0000214:tRNA-intron endonuclease complex:C"], "name": "Sen15_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042778": {"description": "Zinc finger CW-type PWWP domain protein 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whose precise effect on RUNX1 targets is not known", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-8943724:r:Regulation of PTEN gene transcription"], "type": "Family"}, "IPR042797": {"description": "Glutaredoxin domain-containing cysteine-rich protein 1", "go_ids": ["GO:0007605"], "go_terms": ["GO:0007605:sensory perception of sound:P"], "name": "GRXCR1", "pathway_ids": 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{"description": "Ankyrin repeat domain-containing protein 22", "go_ids": [], "go_terms": [], "name": "ANR22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042803": {"description": "Transcription factor 19", "go_ids": ["GO:0010468"], "go_terms": ["GO:0010468:regulation of gene expression:P"], "name": "TCF19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042804": {"description": "Probable G-protein coupled receptor 82", "go_ids": [], "go_terms": [], "name": "GPR82", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042805": {"description": "Proline-rich protein 3", "go_ids": [], "go_terms": [], "name": "PRR3", "pathway_ids": ["R-MMU-9770562", "R-RNO-9770562"], "pathways": ["R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation"], "type": "Family"}, "IPR042808": {"description": "C-type lectin domain family 7 member A", "go_ids": ["GO:0001872", "GO:0071226"], "go_terms": ["GO:0001872:(1->3)-beta-D-glucan binding:F", "GO:0071226:cellular response to molecule of fungal origin:P"], "name": "CLEC7A", "pathway_ids": ["R-MMU-5607764", "R-HSA-5607764"], "pathways": ["R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling"], "type": "Family"}, "IPR042812": {"description": "Sterile alpha motif domain-containing protein 3", "go_ids": [], "go_terms": [], "name": "SAMD3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042814": {"description": "MORN repeat-containing protein 5", "go_ids": [], "go_terms": [], "name": "Morn5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042815": {"description": "Dynein regulatory complex protein 10", "go_ids": [], "go_terms": [], "name": "DRC10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042816": {"description": "Nuclear speckle splicing regulatory protein 1", "go_ids": [], "go_terms": [], "name": "Nsrp1", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-CEL-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR042831": {"description": "Large ribosomal subunit protein mL40, fungi", "go_ids": ["GO:0003735", "GO:0032543"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0032543:mitochondrial translation:P"], "name": "Ribosomal_mL40_fung", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042832": {"description": "PHLDA family", "go_ids": ["GO:0043065", "GO:1901981"], "go_terms": ["GO:0043065:positive regulation of apoptotic process:P", "GO:1901981:phosphatidylinositol phosphate binding:F"], "name": "PHLA1/2/3", "pathway_ids": ["R-MMU-8854521", "R-HSA-8854521", "R-HSA-9841922", "R-RNO-8854521"], "pathways": ["R-MMU-8854521:r:Interaction 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15", "go_ids": [], "go_terms": [], "name": "SIG15", "pathway_ids": ["R-HSA-2172127"], "pathways": ["R-HSA-2172127:r:DAP12 interactions"], "type": "Family"}, "IPR042837": {"description": "Pentraxin-related protein PTX3", "go_ids": ["GO:0006955"], "go_terms": ["GO:0006955:immune response:P"], "name": "PTX3", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR042838": {"description": "Uncharacterized protein KIAA1958", "go_ids": [], "go_terms": [], "name": "KIAA1958", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042839": {"description": "Forkhead box protein M1", "go_ids": ["GO:0003677", "GO:0003700", "GO:0000086"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F", "GO:0000086:G2/M transition of mitotic cell cycle:P"], "name": "FOXM1", "pathway_ids": ["R-HSA-69273", "R-HSA-9725371", "R-RNO-69273", "R-MMU-156711", "R-MMU-69273", "R-RNO-156711", "R-HSA-156711"], "pathways": ["R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-156711:r:Polo-like kinase mediated events", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-156711:r:Polo-like kinase mediated events", "R-HSA-156711:r:Polo-like kinase mediated events"], "type": "Family"}, "IPR042840": {"description": "Lamin tail domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "LMNTD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042841": {"description": "Splicing factor, arginine/serine-rich 19", "go_ids": [], "go_terms": [], "name": "SCAF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042842": {"description": "CD226 antigen", "go_ids": ["GO:0002729"], "go_terms": ["GO:0002729:positive regulation of natural killer cell cytokine production:P"], "name": "CD226", "pathway_ids": ["R-HSA-198933", "R-MMU-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR042846": {"description": "BTB/POZ domain-containing protein 19", "go_ids": [], "go_terms": [], "name": "BTBD19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042847": {"description": "EF-hand calcium-binding domain-containing protein 12", "go_ids": [], "go_terms": [], "name": "EFC12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042848": {"description": "Ribonuclease P protein subunit Rpp38", "go_ids": ["GO:0000172", "GO:0005655", "GO:0001682"], "go_terms": ["GO:0000172:ribonuclease MRP complex:C", "GO:0005655:nucleolar ribonuclease P complex:C", "GO:0001682:tRNA 5'-leader removal:P"], "name": "Rpp38", "pathway_ids": ["R-BTA-6791226", "R-HSA-6791226", "R-MMU-6791226", "R-HSA-6784531"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Family"}, "IPR042849": {"description": "Rho guanine nucleotide exchange factor 33", "go_ids": [], "go_terms": [], "name": "ARHGEF33", "pathway_ids": ["R-HSA-193648", "R-MMU-416482", "R-HSA-416482", "R-MMU-193648"], "pathways": ["R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-193648:r:NRAGE signals death through JNK"], "type": "Family"}, "IPR042855": {"description": "v-SNARE, coiled-coil homology domain", "go_ids": [], "go_terms": [], "name": "V_SNARE_CC", "pathway_ids": ["R-RNO-9013026", 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"R-RNO-8856825", "R-DRE-9013408", "R-RNO-6807878", "R-MMU-888590", "R-HSA-6807878", "R-CEL-449836", "R-MMU-181429", "R-DME-212676", "R-RNO-204005", "R-HSA-888590", "R-BTA-9013408", "R-BTA-8856825", "R-DRE-9013148", "R-MMU-9013026", "R-MMU-1236974", "R-BTA-432722", "R-HSA-9013406", "R-RNO-888590", "R-RNO-449836", "R-DME-9013423"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-CEL-199992:r:trans-Golgi Network Vesicle Budding", "R-MMU-6811438:r:Intra-Golgi traffic", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-264876:r:Insulin processing", "R-RNO-9020591:r:Interleukin-12 signaling", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-BTA-9609523:r:Insertion of 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Release Cycle", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-XTR-6811438:r:Intra-Golgi traffic", "R-DME-9013407:r:RHOH GTPase cycle", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-449836:r:Other interleukin signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-XTR-204005:r:COPII-mediated vesicle transport", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-9013408:r:RHOG GTPase cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-449836:r:Other interleukin signaling", "R-MMU-181429:r:Serotonin Neurotransmitter Release 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channel activity:F"], "name": "TMEM266", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR042858": {"description": "DnaJ homolog subfamily C member 8", "go_ids": [], "go_terms": [], "name": "DNAJC8", "pathway_ids": ["R-HSA-72163", "R-HSA-9770562", "R-HSA-9918481", "R-MMU-9770562", "R-RNO-9770562"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation"], "type": "Family"}, "IPR042859": {"description": "Nucleolar protein 11", "go_ids": ["GO:0030490"], "go_terms": ["GO:0030490:maturation of SSU-rRNA:P"], "name": "NOL11", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-HSA-6790901", "R-HSA-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA 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in the cytosol", "R-HSA-1855191:r:Synthesis of IPs in the nucleus", "R-DRE-1855167:r:Synthesis of pyrophosphates in the cytosol"], "type": "Homologous_superfamily"}, "IPR043002": {"description": "Spike glycoprotein, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Spike_N_sf", "pathway_ids": ["R-HSA-9679509", "R-HSA-9683686", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9694548", "R-HSA-9692916", "R-HSA-166662", "R-HSA-166663", "R-HSA-9694614", "R-HSA-9694322", "R-HSA-9694635"], "pathways": ["R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9694635:r:Translation of Structural Proteins"], "type": "Homologous_superfamily"}, "IPR043003": {"description": "FANCL, UBC-like domain 3 superfamily", "go_ids": [], "go_terms": [], "name": "FANCL_d3_sf", "pathway_ids": ["PWY-7511", "R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Homologous_superfamily"}, "IPR043004": {"description": "MvaI/BcnI restriction endonuclease, catalytic domain", "go_ids": [], "go_terms": [], "name": "MvaI_BcnI_cat", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043005": {"description": "MvaI/BcnI restriction endonuclease, recognition domain", "go_ids": [], "go_terms": [], "name": "MvaI_BcnI_rec", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043006": {"description": "Cyanuric acid hydrolase/Barbiturase, repeating unit B", "go_ids": [], "go_terms": [], "name": "AtzD/Barbiturase_RUB", "pathway_ids": ["PWY-8025", "PWY-5169"], "pathways": ["PWY-8025:t:cyanuric acid degradation I", "PWY-5169:t:cyanuric acid degradation II"], "type": "Homologous_superfamily"}, "IPR043007": {"description": "Cyanuric acid hydrolase/Barbiturase, repeating unit C", "go_ids": [], "go_terms": [], "name": "AtzD/Barbiturase_RUC", "pathway_ids": ["PWY-8025", "PWY-5169"], "pathways": ["PWY-8025:t:cyanuric acid degradation I", "PWY-5169:t:cyanuric acid degradation II"], "type": "Homologous_superfamily"}, "IPR043008": {"description": "Cyanuric acid hydrolase/Barbiturase, repeating unit A", "go_ids": [], "go_terms": [], "name": "AtzD/Barbiturase_RUA", "pathway_ids": ["PWY-8025", "PWY-5169"], "pathways": ["PWY-8025:t:cyanuric acid degradation I", "PWY-5169:t:cyanuric acid degradation II"], "type": "Homologous_superfamily"}, "IPR043009": {"description": "LOR/SDH bifunctional enzyme, conserved domain superfamily", "go_ids": [], "go_terms": [], "name": "LOR/SDH_bifunc_enz_cons_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043010": {"description": "Phenol hydroxylase domain superfamily", "go_ids": [], "go_terms": [], "name": "Phenol_hydroxylase_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043011": {"description": "Bunyavirus nucleocapsid (N) , C-terminal domain", "go_ids": [], "go_terms": [], "name": "Bunya_nucleocap_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043012": {"description": "Bunyavirus nucleocapsid (N) , N-terminal domain", "go_ids": [], "go_terms": [], "name": "Bunya_nucleocap_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043013": {"description": "Zinc finger, TRAF-type, N-terminal", "go_ids": [], "go_terms": [], "name": "Znf_TRAF_N", "pathway_ids": ["R-MMU-8951664", "R-HSA-983168", "R-RNO-983168", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Homologous_superfamily"}, "IPR043014": {"description": "Nibrin, second BRCT domain superfamily", "go_ids": [], "go_terms": [], "name": "Nibrin_BRCT2_sf", "pathway_ids": ["R-DRE-5693607", "R-HSA-5685942", "R-MMU-5693571", "R-HSA-5693616", "R-HSA-9704646", "R-RNO-5693565", "R-GGA-351433", "R-RNO-5685939", "R-MMU-6804756", "R-HSA-5693565", "R-DRE-5685939", "R-RNO-5693548", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-5693565", "R-MMU-69473", "R-DRE-5693568", "R-DRE-5693571", "R-HSA-9709570", "R-HSA-5693607", "R-DRE-2559586", "R-GGA-351444", "R-RNO-5685938", "R-HSA-912446", "R-MMU-5685939", "R-RNO-6804756", "R-MMU-5693568", "R-GGA-351442", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-RNO-2559586", "R-GGA-217106", "R-MMU-5693548", "R-RNO-5693579", "R-HSA-69473", "R-MMU-2559586", "R-RNO-5693607", "R-HSA-9709603", "R-DRE-5685942", "R-MMU-5685942", "R-RNO-5693571", "R-HSA-5685939", "R-RNO-69473", "R-RNO-5685942", "R-DRE-5693548", "R-HSA-5693571", "R-HSA-6804756", "R-HSA-9704331", "R-DRE-69473", "R-RNO-5693568", "R-DRE-5693616", "R-DRE-5693565", "R-HSA-5693554", "R-HSA-5693548", "R-RNO-5693616", "R-HSA-5693579", "R-HSA-2559586", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DRE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-351444:r:Recruitment of repair and signaling proteins to double-strand breaks", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-912446:r:Meiotic recombination", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-GGA-351442:r:ATM mediated response to DNA double-strand break", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-217106:r:Chk1-controlled and DNA-damage induced centrosome duplication", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693548:r:Sensing of DNA Double Strand Breaks", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Homologous_superfamily"}, "IPR043015": {"description": "Arenavirus glycoprotein, zinc binding domain", "go_ids": [], "go_terms": [], "name": "Arena_glycoprot_zinc-bd", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043016": {"description": "IFT81, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "IFT81_N_sf", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Homologous_superfamily"}, "IPR043017": {"description": "WIYLD domain superfamily", "go_ids": [], "go_terms": [], "name": "WIYLD_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043018": {"description": "Poxvirus domain superfamily", "go_ids": [], "go_terms": [], "name": "Poxvirus_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043019": {"description": "T3SS negative regulator GrlR domain superfamily", "go_ids": [], "go_terms": [], "name": "GrlR_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043020": {"description": "GCM domain, large subdomain", "go_ids": [], "go_terms": [], "name": "GCM_large", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043021": {"description": "GCM, small domain", "go_ids": [], "go_terms": [], "name": "GCM_small", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043022": {"description": "Peptide-N-glycosidase F, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "PngaseF_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043023": {"description": "Major vault protein repeat domain superfamily", "go_ids": [], "go_terms": [], "name": "MVP_rep_sf", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR043024": {"description": "Kinase associated-1 domain superfamily, fungal", "go_ids": [], "go_terms": [], "name": "KA1_sf_fungal", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043025": {"description": "Dam replacing family, catalytic PD-(D/E)XK domain", "go_ids": [], "go_terms": [], "name": "DRP_PD-(D/E)XK_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043026": {"description": "Orbivirus VP4 core, C-terminal", "go_ids": [], "go_terms": [], "name": "Orbi_VP4_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043029": {"description": "Catechol 1,2-dioxygenase multimerisation domain", "go_ids": [], "go_terms": [], "name": "1_2-CTD_multi_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043030": {"description": "Beta-1,3-glucan-binding protein, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "BGBP_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043031": {"description": "Viral ssDNA binding protein, head domain", "go_ids": [], "go_terms": [], "name": "Viral_ssDBP_head", "pathway_ids": ["R-HSA-9610379", "R-HSA-9609690"], "pathways": ["R-HSA-9610379:r:HCMV Late Events", "R-HSA-9609690:r:HCMV Early Events"], "type": "Homologous_superfamily"}, "IPR043032": {"description": "PvsD/AcsD-like, thumb domain, helical bundle", "go_ids": [], "go_terms": [], "name": "PvsD/AcsD-like_thumb_helix", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043033": {"description": "PvsD/AcsD-like, thumb domain, four stranded beta-sheet", "go_ids": [], "go_terms": [], "name": "PvsD/AcsD-like_thumb_beta", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043034": {"description": "DNA polymerase alpha, subunit B, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "DNA_pol_alpha_B_N_sf", "pathway_ids": ["R-HSA-113501", "R-MMU-174430", "R-RNO-68962", "R-CEL-69091", "R-HSA-68952", "R-CEL-68962", "R-MMU-68962", "R-RNO-174430", "R-HSA-174430", "R-MMU-113501", "R-CEL-113501", "R-DME-69091", "R-CEL-69166", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-DME-113501", "R-RNO-69091", "R-RNO-69183", "R-MMU-68952", "R-HSA-9710421", "R-DME-68962", "R-RNO-69166", "R-RNO-113501", "R-CEL-69183", "R-CEL-68952", "R-MMU-69166", "R-HSA-69183", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-HSA-69091", "R-RNO-68952", "R-MMU-174411", "R-RNO-174411", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-CEL-69091:r:Polymerase switching", "R-HSA-68952:r:DNA replication initiation", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-69091:r:Polymerase switching", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69091:r:Polymerase switching", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-MMU-68952:r:DNA replication initiation", "R-HSA-9710421:r:Defective pyroptosis", "R-DME-68962:r:Activation of the pre-replicative complex", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-CEL-68952:r:DNA replication initiation", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-HSA-69091:r:Polymerase switching", "R-RNO-68952:r:DNA replication initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Homologous_superfamily"}, "IPR043035": {"description": "Large ribosomal subunit protein mL64 domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL64_sf", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-RNO-5389840"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Homologous_superfamily"}, "IPR043036": {"description": "Phosphoprotein, C-terminal domain, viral", "go_ids": [], "go_terms": [], "name": "Phosphoprotein_C_viral", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043037": {"description": "CFA/I fimbrial subunit E, adhesin domain", "go_ids": [], "go_terms": [], "name": "CfaE_adhesin", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043038": {"description": "Antitoxin VbhA domain superfamily", "go_ids": [], "go_terms": [], "name": "VbhA_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043039": {"description": "TBC1 domain family member 7, domain 2", "go_ids": [], "go_terms": [], "name": "TBC1D7_dom2", "pathway_ids": ["R-HSA-8854214", "R-XTR-8854214", "R-MMU-8854214", "R-BTA-8854214"], "pathways": ["R-HSA-8854214:r:TBC/RABGAPs", "R-XTR-8854214:r:TBC/RABGAPs", "R-MMU-8854214:r:TBC/RABGAPs", "R-BTA-8854214:r:TBC/RABGAPs"], "type": "Homologous_superfamily"}, "IPR043043": {"description": "DNA packaging protein FI, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Packaging_FI_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043044": {"description": "TPA1/Ofd1, C-terminal", "go_ids": [], "go_terms": [], "name": "TPA1/Ofd1_C", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-SCE-9629569", "R-SPO-9629569"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-SCE-9629569:r:Protein hydroxylation", "R-SPO-9629569:r:Protein hydroxylation"], "type": "Homologous_superfamily"}, "IPR043045": {"description": "PvsD/AcsD-like, palm domain, helix bundle", "go_ids": [], "go_terms": [], "name": "PvsD/AcsD-like_palm_helix", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043046": {"description": "Interleukin-17 receptor A/B, FnIII-like domain 2 superfamily", "go_ids": [], "go_terms": [], "name": "IL17RA/B_FnIII-like_2_sf", "pathway_ids": ["R-HSA-448424", "R-HSA-9705671"], "pathways": ["R-HSA-448424:r:Interleukin-17 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses"], "type": "Homologous_superfamily"}, "IPR043047": {"description": "Hri1, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Hri1_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043048": {"description": "Birnavirus VP3, domain 1", "go_ids": [], "go_terms": [], "name": "Birna_VP3_dom1", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR043049": {"description": "Birnavirus VP3, domain 2", "go_ids": [], "go_terms": [], "name": "Birna_VP3_dom2", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR043053": {"description": "Pre-hexon-linking protein IIIa, N-terminal", "go_ids": [], "go_terms": [], "name": "Hex_IIIa_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043056": {"description": "LuxQ periplasmic domain, N-terminal subdomain", "go_ids": [], "go_terms": [], "name": "LuxQ-periplasm_N", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Homologous_superfamily"}, "IPR043057": {"description": "Erythrocyte binding antigen 175, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "EBA-175_C_sf", "pathway_ids": ["R-HSA-202733"], "pathways": ["R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Homologous_superfamily"}, "IPR043058": {"description": "KRIT, N-terminal NPxY motif-rich domain superfamily", "go_ids": [], "go_terms": [], "name": "NUDIX_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043060": {"description": "Filoviruses VP35 interferon inhibitory domain, helical subdomain", "go_ids": [], "go_terms": [], "name": "VP35_IID_hlx", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043061": {"description": "Filoviruses VP35 interferon inhibitory domain, beta-sheet subdomain", "go_ids": [], "go_terms": [], "name": "VP35_IID_b-sht", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043062": {"description": "Pneumovirus matrix, N-terminal", "go_ids": [], "go_terms": [], "name": "Pneu_matrix_N", "pathway_ids": ["R-HSA-9828721", 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"PWY-7733", "PWY-7706", "PWY-7402", "PWY-8320", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane carboxylate)", "PWY-8320:t:(3R)-N-[(2S)-1-hydroxy-6-[(3R)-3-isocyanobutanamido]hexan-2-yl]-3-isocyanobutanamide biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-6995:t:5-hydroxymethylfurfural degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-3602:t:L-carnitine degradation III", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7292:t:oleate beta-oxidation (thioesterase-dependent, yeast)", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-6917:t:vernolate biosynthesis 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"PWY-7115", "PWY-6142", "PWY-7117", "PWY-241", "PWY-5744"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-241:t:C4 photosynthetic carbon assimilation cycle, NADP-ME type", "PWY-5744:t:glyoxylate assimilation"], "type": "Homologous_superfamily"}, "IPR043067": {"description": "Calcium binding protein CcbP, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "CcbP_b-brl", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043068": {"description": "Uracil DNA glycosylase inhibitor superfamily", "go_ids": [], "go_terms": [], "name": "SAUGI_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043069": {"description": "Stc1 domain superfamily", "go_ids": [], "go_terms": [], "name": "Stc1_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043070": {"description": "Spidroin, repetitive domain", "go_ids": [], "go_terms": [], "name": "Spidroin_repeat", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043071": {"description": "Staphylcoagulase, N-terminal, subdomain 2", "go_ids": [], "go_terms": [], "name": "Staphylcoagulase_N_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043072": {"description": "Staphylcoagulase, N-terminal, subdomain 1", "go_ids": [], "go_terms": [], "name": "Staphylcoagulase_N_1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043073": {"description": "Baseplate protein Gp16, domain D4", "go_ids": [], "go_terms": [], "name": "Gp16_domD4", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043075": {"description": "Baseplate protein Gp16, domain 1 and 2", "go_ids": [], "go_terms": [], "name": "Gp16_dom1_2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043076": {"description": "Cell-cell fusogen EFF/AFF, domain 3", "go_ids": [], "go_terms": [], "name": "Fusogen_EFF/AFF_dom3", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043077": {"description": "Chaperone protein gp12 superfamily", "go_ids": [], "go_terms": [], "name": "Gp12_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043078": {"description": "Sialyltransferase, N-terminal GT-B Rossman nucleotide-binding domain", "go_ids": [], "go_terms": [], "name": "Sialyltransferase_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043079": {"description": "EV matrix protein, N-terminal", "go_ids": [], "go_terms": [], "name": "EV_matrix_protein_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043080": {"description": "Hemolytic toxin, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Hemolysin_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043081": {"description": "Apolipoprotein C-I domain superfamily", "go_ids": [], "go_terms": [], "name": "ApoC-1_sf", "pathway_ids": ["R-MMU-8866423", "R-MMU-8964046", "R-CFA-8866423", "R-HSA-8866423", "R-RNO-8866423", "R-CFA-8964046", "R-HSA-9029569", "R-RNO-8964046", "R-HSA-8964046"], "pathways": ["R-MMU-8866423:r:VLDL assembly", "R-MMU-8964046:r:VLDL clearance", "R-CFA-8866423:r:VLDL assembly", "R-HSA-8866423:r:VLDL assembly", "R-RNO-8866423:r:VLDL assembly", "R-CFA-8964046:r:VLDL clearance", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-8964046:r:VLDL clearance", "R-HSA-8964046:r:VLDL clearance"], "type": "Homologous_superfamily"}, "IPR043082": {"description": "Baculovirus occlusion-derived virus envelope, E66, core domain", "go_ids": [], "go_terms": [], "name": "Baculo_ODV-E66_core", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043083": {"description": "Gp27, baseplate hub, domain 3", "go_ids": [], "go_terms": [], "name": "Gp27_dom3", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043084": {"description": "Gp27, baseplate hub, domain 4", "go_ids": [], "go_terms": [], "name": "Gp27_dom4", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043085": {"description": "Gp27, baseplate hub, domain 2", "go_ids": [], "go_terms": [], "name": "Gp27_dom2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043086": {"description": "EME1, nuclease domain, subdomain 1", "go_ids": [], "go_terms": [], "name": "EME1_nucdom_sub1", "pathway_ids": ["R-HSA-5693568", "R-HSA-6783310", "R-MMU-5693568", "R-MMU-6783310"], "pathways": ["R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Homologous_superfamily"}, "IPR043087": {"description": "EME1, nuclease domain, subdomain 2", "go_ids": [], "go_terms": [], "name": "Eme1_nucdom_sub2", "pathway_ids": ["R-HSA-5693568", "R-HSA-6783310", "R-MMU-5693568", "R-MMU-6783310"], "pathways": ["R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Homologous_superfamily"}, "IPR043088": {"description": "Surface-adhesin protein E", "go_ids": [], "go_terms": [], "name": "Adhesin_E", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043089": {"description": "Dot/Icm secretion system IcmQ, C-terminal", "go_ids": [], "go_terms": [], "name": "Dot_Icm_IcmQ_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043090": {"description": "Low molecular weight S layer protein, N-terminal, subdomain", "go_ids": [], "go_terms": [], "name": "Low_molc_weight_S-layer_N_sub", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043091": {"description": "Restriction endonuclease, type II, AvaI/BsoBI, helical domain", "go_ids": [], "go_terms": [], "name": "Restr_endonucII_AvaI/BsoBI_hel", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043094": {"description": "Nab2/ZC3H14, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Nab2/ZC3H14_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043096": {"description": "Poxvirus mRNA capping enzyme, small subunit superfamily", "go_ids": [], "go_terms": [], "name": "Poxvirus_mRNA-cap_ssu_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043097": {"description": "Phosphoprotein P, oligomerisation domain 1", 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"Homologous_superfamily"}, "IPR043115": {"description": "D212, catalytic domain superfamily", "go_ids": [], "go_terms": [], "name": "D212_cat_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043116": {"description": "Outer capsid protein VP9, N-terminal", "go_ids": [], "go_terms": [], "name": "VP9_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043117": {"description": "Restriction endonuclease, type II SfiI, domain 2", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_SfiI_dom2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043118": {"description": "Restriction endonuclease, type II SfiI, domain 1", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_SfiI_dom1", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043119": {"description": "Rac1-binding domain, C-terminal", "go_ids": [], "go_terms": [], "name": "Rac1-bd_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043120": {"description": "Rac1-binding domain, N-terminal", "go_ids": [], "go_terms": [], "name": "Rac1-db_N", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043121": {"description": "Restriction endonuclease, type II, BglI superfamily", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc_II_BglI_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043123": {"description": "Phage bIL170 RBP, head domain", "go_ids": [], "go_terms": [], "name": "Phage_bIL170_RBP_head", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043124": {"description": "DNA terminal protein Gp3, C-terminal", "go_ids": [], "go_terms": [], "name": "DNA_terminal_Gp3_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043125": {"description": "Vibrio cholerae toxin co-regulated pilus biosynthesis F, C-terminal", "go_ids": [], "go_terms": [], "name": "TcpF_C", "pathway_ids": 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reuptake and degradation", "R-DME-114516:r:Disinhibition of SNARE formation", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Homologous_superfamily"}, "IPR043128": {"description": "Reverse transcriptase/Diguanylate cyclase domain", "go_ids": [], "go_terms": [], "name": "Rev_trsase/Diguanyl_cyclase", "pathway_ids": ["R-HSA-180910", "R-HSA-5685942", "R-HSA-8854214", "R-MMU-6782135", "R-SPO-5656169", "R-SPO-5655862", "R-SPO-5656121", "R-HSA-5696397", "R-MMU-110320", "R-MMU-110312", "R-SPO-110312", "R-DME-5656121", "R-GGA-5655862", "R-HSA-164525", "R-HSA-5655862", "R-GGA-353503", "R-HSA-162592", "R-DME-5655862", "R-DME-110312", "R-HSA-6782210", "R-HSA-175474", "R-HSA-5621480", "R-HSA-5656169", "R-HSA-5656121", "R-MMU-5696400", "R-HSA-173107", "R-MMU-5655862", "R-GGA-5656121", "R-DME-110320", "R-HSA-164516", 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"R-HSA-201722", "R-HSA-933541", "R-HSA-9909649", "R-DME-8936459", "R-HSA-933543", "R-HSA-877300", "R-HSA-9692916", "R-RNO-9770562", "R-MMU-983168", "R-HSA-9818564", "R-MMU-9770562", "R-MMU-373760"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-8951664:r:Neddylation", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-8951664:r:Neddylation", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-8851805:r:MET activates RAS signaling", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-DME-373760:r:L1CAM interactions", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-9635465:r:Suppression of apoptosis", "R-DDI-5673000:r:RAF activation", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-RNO-8951664:r:Neddylation", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-844456:r:The NLRP3 inflammasome", "R-DRE-8851805:r:MET activates RAS signaling", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8951664:r:Neddylation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-RNO-2672351:r:Stimuli-sensing channels", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9833110:r:RSV-host interactions", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DDI-3295583:r:TRP channels", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-373760:r:L1CAM interactions"], "type": "Homologous_superfamily"}, "IPR043137": {"description": "Gamma-glutamyltranspeptidase, small subunit, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GGT_ssub_C", "pathway_ids": ["PWY-8301", "PWY-5826", "PWY-8001", "PWY-7559", "PWY-4061", "PWY-6842", "PWY-7112", "PWY-4041", "PWY-8355", "R-HSA-2142691", "R-SPO-2142691", "R-MMU-9753281", "R-RNO-174403", "R-RNO-9753281", "R-SPO-5423646", "R-RNO-5423646", "R-HSA-5423646", "R-HSA-9753281", "R-SCE-174403", "R-MMU-5423646", "R-SCE-5423646", "R-RNO-2142691", "R-HSA-5579022", "R-BTA-5423646", "R-BTA-174403", "R-MMU-174403", "R-SPO-174403", "R-SCE-2142691", "R-MMU-2142691", "R-HSA-9664535", "R-SPO-9753281", "R-HSA-9035968", "R-SCE-9753281", "R-HSA-174403", "R-BTA-9753281"], "pathways": ["PWY-8301:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis", "PWY-5826:t:hypoglycin biosynthesis", "PWY-8001:t:felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis", "PWY-7559:t:glutathione degradation (DUG pathway)", "PWY-4061:t:glutathione-mediated detoxification I", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-7112:t:4-hydroxy-2-nonenal detoxification", "PWY-4041:t:gamma-glutamyl cycle", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9753281:r:Paracetamol ADME", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-RNO-9753281:r:Paracetamol ADME", "R-SPO-5423646:r:Aflatoxin activation and detoxification", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-HSA-9753281:r:Paracetamol ADME", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-SCE-5423646:r:Aflatoxin activation and detoxification", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-5579022:r:Defective GGT1 causes GLUTH", "R-BTA-5423646:r:Aflatoxin activation and detoxification", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9664535:r:LTC4-CYSLTR mediated IL4 production", "R-SPO-9753281:r:Paracetamol ADME", "R-HSA-9035968:r:Defective GGT1 in aflatoxin detoxification causes GLUTH", "R-SCE-9753281:r:Paracetamol ADME", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-BTA-9753281:r:Paracetamol ADME"], "type": "Homologous_superfamily"}, "IPR043138": {"description": "Gamma-glutamyltranspeptidase, large subunit", "go_ids": [], "go_terms": [], "name": "GGT_lsub", "pathway_ids": ["PWY-8301", "PWY-5826", "PWY-8001", "PWY-7559", "PWY-4061", "PWY-6842", "PWY-7112", "PWY-4041", "PWY-8355", "R-HSA-2142691", "R-SPO-2142691", "R-MMU-9753281", "R-RNO-174403", "R-RNO-9753281", "R-SPO-5423646", "R-RNO-5423646", "R-HSA-5423646", "R-HSA-9753281", "R-SCE-174403", "R-MMU-5423646", "R-SCE-5423646", "R-RNO-2142691", "R-HSA-5579022", "R-BTA-5423646", "R-BTA-174403", "R-MMU-174403", "R-SPO-174403", "R-SCE-2142691", "R-MMU-2142691", "R-HSA-9664535", "R-SPO-9753281", "R-HSA-9035968", "R-SCE-9753281", "R-HSA-174403", "R-BTA-9753281"], "pathways": ["PWY-8301:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis", "PWY-5826:t:hypoglycin biosynthesis", "PWY-8001:t:felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis", "PWY-7559:t:glutathione degradation (DUG pathway)", "PWY-4061:t:glutathione-mediated detoxification I", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-7112:t:4-hydroxy-2-nonenal detoxification", "PWY-4041:t:gamma-glutamyl cycle", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-9753281:r:Paracetamol ADME", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-RNO-9753281:r:Paracetamol ADME", "R-SPO-5423646:r:Aflatoxin activation and detoxification", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-HSA-9753281:r:Paracetamol ADME", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-SCE-5423646:r:Aflatoxin activation and detoxification", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-5579022:r:Defective GGT1 causes GLUTH", "R-BTA-5423646:r:Aflatoxin activation and detoxification", "R-BTA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9664535:r:LTC4-CYSLTR mediated IL4 production", "R-SPO-9753281:r:Paracetamol ADME", "R-HSA-9035968:r:Defective GGT1 in aflatoxin detoxification causes GLUTH", "R-SCE-9753281:r:Paracetamol ADME", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-BTA-9753281:r:Paracetamol ADME"], "type": "Homologous_superfamily"}, "IPR043140": {"description": "Small ribosomal subunit protein uS14 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_uS14_sf", "pathway_ids": ["R-BTA-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-RNO-72695", "R-HSA-72695", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-DME-72706", "R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-DDI-9954714", "R-BTA-72695", "R-SCE-72702", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-DDI-72695", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-RNO-72649", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-SPO-72689", "R-DDI-72702", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-SPO-72702", "R-HSA-9954716", "R-DME-156827", "R-MMU-72689", "R-SCE-72706", "R-DDI-6791226", "R-DME-72649", "R-HSA-156827", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DME-1799339", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-SCE-156827", "R-MMU-72702", "R-DME-72695", "R-DME-975956", "R-BTA-9954716", "R-DME-975957", "R-SPO-72649", "R-SPO-72695", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-HSA-9754678", "R-SCE-9954714", "R-HSA-72649", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-SCE-72649", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent 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"R-RNO-181430", "R-MMU-210500", "R-SPO-204005", "R-MMU-181429", "R-CEL-449836", "R-DME-212676", "R-RNO-204005", "R-HSA-888590", "R-DME-114516", "R-BTA-181429", "R-RNO-888590", "R-RNO-449836", "R-HSA-422356"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-114516:r:Disinhibition of SNARE formation", "R-MMU-6811438:r:Intra-Golgi traffic", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-114516:r:Disinhibition of SNARE formation", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-114608:r:Platelet degranulation", "R-DDI-114608:r:Platelet degranulation", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", 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"R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", "R-MMU-3371497", "R-SPO-6798695", "R-HSA-2132295", "R-HSA-2467813", "R-RNO-2500257", "R-SCE-6798695", "R-RNO-3371497", "R-HSA-3371497", "R-MMU-6807878", "R-RNO-5620912", "R-MMU-380284", "R-HSA-2565942", "R-RNO-2565942", "R-HSA-68877", "R-HSA-5610787", "R-MMU-2132295", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-PFA-3371497", "R-MMU-2500257", "R-RNO-68877", "R-RNO-2132295", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-RNO-6807878", "R-DME-6798695", "R-HSA-6807878", "R-CEL-6811436", "R-DME-9646399", "R-HSA-380270", "R-RNO-380259", "R-DDI-6807878", "R-PFA-6798695", "R-RNO-9646399", "R-RNO-9648025", "R-HSA-5663220", "R-HSA-380259"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", 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degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Homologous_superfamily"}, "IPR043158": {"description": "Wnt, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Wnt_C", "pathway_ids": ["R-MMU-9856649", "R-RNO-201681", "R-MMU-8856828", "R-HSA-373080", "R-RNO-5140745", "R-MMU-4641263", "R-HSA-8856828", "R-CEL-5099900", "R-MMU-5099900", "R-MMU-4086398", "R-RNO-3238698", "R-DME-4086400", "R-XTR-3238698", "R-DME-5099900", "R-DRE-4641262", "R-DME-4641262", "R-DME-209472", "R-DME-201681", "R-CEL-4086398", "R-HSA-5140745", "R-DME-4608870", "R-HSA-9834899", "R-RNO-4086400", "R-DRE-3238698", "R-HSA-3238698", "R-MMU-4086400", "R-DME-5140745", "R-MMU-201681", "R-MMU-5140745", "R-DRE-201681", "R-HSA-4608870", "R-XTR-4086398", "R-MMU-4641262", "R-HSA-9793380", "R-CEL-4608870", "R-CEL-8856825", "R-CEL-201681", "R-HSA-201681", "R-MMU-3238698", "R-MMU-8856825", "R-GGA-9856649", "R-CEL-3238698", "R-BTA-3238698", "R-CEL-5140745", "R-HSA-9832991", "R-HSA-4641262", "R-HSA-5340588", "R-RNO-8856828", "R-HSA-4086398", "R-DME-209387", "R-RNO-5099900", "R-MMU-4608870", "R-HSA-3772470", "R-CEL-8856828", "R-RNO-4608870", "R-RNO-8856825", "R-DME-3238698", "R-HSA-4641263", "R-HSA-4086400", "R-HSA-381340", "R-HSA-5099900", "R-GGA-4086398", "R-GGA-4641262", "R-GGA-4641263", "R-HSA-9673324", "R-HSA-9830674", "R-RNO-4086398", "R-DME-209440", "R-HSA-8856825", "R-DRE-4086400", "R-GGA-201681", "R-HSA-9831926", "R-HSA-9856649", "R-GGA-3238698"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-CEL-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-4086398:r:Ca2+ pathway", "R-RNO-3238698:r:WNT ligand biogenesis and trafficking", "R-DME-4086400:r:PCP/CE pathway", "R-XTR-3238698:r:WNT ligand biogenesis and trafficking", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-209472:r:Assembly of receptor complex", "R-DME-201681:r:TCF dependent signaling in response to WNT", "R-CEL-4086398:r:Ca2+ pathway", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-9834899:r:Specification of the neural plate border", "R-RNO-4086400:r:PCP/CE pathway", "R-DRE-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-4086400:r:PCP/CE pathway", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DRE-201681:r:TCF dependent signaling in response to WNT", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-XTR-4086398:r:Ca2+ pathway", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-201681:r:TCF dependent signaling in response to WNT", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CEL-3238698:r:WNT ligand biogenesis and trafficking", "R-BTA-3238698:r:WNT ligand biogenesis and trafficking", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-9832991:r:Formation of the posterior neural plate", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-4086398:r:Ca2+ pathway", "R-DME-209387:r:Phosphorylation of ARR", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-GGA-4086398:r:Ca2+ pathway", "R-GGA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-HSA-9830674:r:Formation of the ureteric bud", "R-RNO-4086398:r:Ca2+ pathway", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-4086400:r:PCP/CE pathway", "R-GGA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-9831926:r:Nephron development", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-GGA-3238698:r:WNT ligand biogenesis and trafficking"], "type": "Homologous_superfamily"}, "IPR043159": {"description": "D-galactoside/L-rhamnose binding SUEL lectin domain superfamily", "go_ids": [], "go_terms": [], "name": "Lectin_gal-bd_sf", "pathway_ids": ["R-DME-9619665", "R-DME-373080", "R-CEL-373080", "R-CEL-9619665", "R-DME-6798695", "R-CEL-6798695"], "pathways": ["R-DME-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-CEL-373080:r:Class B/2 (Secretin family receptors)", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR043160": {"description": "Dynein heavy chain, C-terminal domain, barrel region", "go_ids": [], "go_terms": [], "name": "Dynein_C_barrel", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", 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"R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DDI-9646399:r:Aggrephagy", "R-RNO-5610787:r:Hedgehog 'off' state", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620924:r:Intraflagellar transport", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-PFA-9646399:r:Aggrephagy", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-9646399:r:Aggrephagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-5620924:r:Intraflagellar transport", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Homologous_superfamily"}, "IPR043161": {"description": "Dedicator of cytokinesis, C-terminal, lobe A", "go_ids": [], "go_terms": [], "name": "DOCK_C_lobe_A", "pathway_ids": ["R-HSA-9013409", "R-HSA-6798695", "R-HSA-8875555", "R-MMU-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-983231", "R-HSA-418885", "R-MMU-4420097", "R-HSA-8849471", "R-HSA-4420097", "R-HSA-9032759", "R-HSA-9013423", "R-SCE-9013149", "R-HSA-9013148", "R-HSA-164944", "R-DRE-9013149", "R-HSA-9013408", "R-MMU-8849471", "R-HSA-983231", "R-HSA-2029482", "R-MMU-2029482", "R-HSA-9013404", "R-DRE-983231", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-MMU-8875555", "R-HSA-8980692", "R-MMU-9013149", "R-MMU-9032759", "R-MMU-6798695", "R-HSA-9664422", "R-SCE-983231", "R-MMU-418885"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-164944:r:Nef and signal transduction", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Homologous_superfamily"}, "IPR043162": {"description": "Dedicator of cytokinesis, C-terminal, lobe C", "go_ids": [], "go_terms": [], "name": "DOCK_C_lobe_C", "pathway_ids": ["R-HSA-9013409", "R-HSA-6798695", "R-HSA-8875555", "R-MMU-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-983231", "R-HSA-418885", "R-MMU-4420097", "R-HSA-8849471", "R-HSA-4420097", "R-HSA-9032759", "R-HSA-9013423", "R-SCE-9013149", "R-HSA-9013148", "R-HSA-164944", "R-DRE-9013149", "R-HSA-9013408", "R-MMU-8849471", "R-HSA-983231", "R-HSA-2029482", "R-MMU-2029482", "R-HSA-9013404", "R-DRE-983231", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-MMU-8875555", "R-HSA-8980692", "R-MMU-9013149", "R-MMU-9032759", "R-MMU-6798695", "R-HSA-9664422", "R-SCE-983231", "R-MMU-418885"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-164944:r:Nef and signal transduction", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Homologous_superfamily"}, "IPR043163": {"description": "DsrC-like protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DsrC-like_N", "pathway_ids": ["PWY-7889", "PWY-7888", "PWY-6892", "PWY-5303", "PWY-7904", "PWY-7250", "PWY-7892", "PWY-8164", "PWY-6675", "PWY-8179", "PWY-7891", "PWY-7887"], "pathways": ["PWY-7889:t:tRNA-uridine 2-thiolation (mammalian mitochondria)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6892:t:thiazole component of thiamine diphosphate biosynthesis I", "PWY-5303:t:thiosulfate oxidation II (via tetrathionate)", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-8164:t:bis(guanylyl molybdopterin) cofactor sulfurylation", "PWY-6675:t:sulfur oxidation IV (intracellular sulfur)", "PWY-8179:t:platensimycin biosynthesis", "PWY-7891:t:tRNA-uridine 2-thiolation (yeast mitochondria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation"], "type": "Homologous_superfamily"}, "IPR043164": {"description": "Large ribosomal subunit protein uL10-like, insertion domain superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL10-like_insert_sf", "pathway_ids": ["R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-DRE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-MMU-6791226", "R-RNO-975957", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-DRE-9954714", "R-SCE-975956", "R-CEL-1799339", "R-HSA-8950505", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-DRE-1799339", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-CEL-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-72689", "R-SCE-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-975956", "R-DRE-975956", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-HSA-975957", "R-DME-9954714", "R-DRE-72689", "R-DRE-9954716", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon 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(EJC)", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Homologous_superfamily"}, "IPR043165": {"description": "Pseudouridine synthase, TruD, insertion domain superfamily", "go_ids": [], "go_terms": [], "name": "TruD_insert_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043166": {"description": "LarA-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LarA-like_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043167": {"description": "LpxI, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "LpxI_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043168": {"description": "DegV, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DegV_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043169": {"description": "Phosphomannomutase, cap domain", "go_ids": [], "go_terms": [], "name": "PMM_cap", "pathway_ids": ["PWY-7586", "PWY-7456", "PWY-5659", "R-HSA-446205", "R-SPO-446205", "R-DME-446205", "R-DDI-446205", "R-MMU-446205", "R-BTA-446205", "R-CEL-446205", "R-SCE-446205", "R-PFA-446205", "R-HSA-4043911"], "pathways": ["PWY-7586:t:beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation", "PWY-7456:t:beta-(1,4)-mannan degradation", "PWY-5659:t:GDP-mannose biosynthesis", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-DME-446205:r:Synthesis of GDP-mannose", "R-DDI-446205:r:Synthesis of GDP-mannose", "R-MMU-446205:r:Synthesis of GDP-mannose", "R-BTA-446205:r:Synthesis of GDP-mannose", "R-CEL-446205:r:Synthesis of GDP-mannose", "R-SCE-446205:r:Synthesis of GDP-mannose", "R-PFA-446205:r:Synthesis of GDP-mannose", "R-HSA-4043911:r:Defective PMM2 causes PMM2-CDG"], "type": "Homologous_superfamily"}, "IPR043170": {"description": "Phosphotyrosyl phosphatase activator, C-terminal lid domain", "go_ids": [], "go_terms": [], "name": "PTPA_C_lid", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043171": {"description": "Ap4A phosphorylase 1/2-like", "go_ids": [], "go_terms": [], "name": "Ap4A_phos1/2-like", "pathway_ids": ["PWY-5279"], "pathways": ["PWY-5279:t:sulfite oxidation II"], "type": "Homologous_superfamily"}, "IPR043172": {"description": "Prp8 RNase domain IV, palm region", "go_ids": [], "go_terms": [], "name": "Prp8_domainIV_palm", "pathway_ids": ["R-HSA-72163", "R-CEL-72165", "R-MMU-72165", "R-MMU-72163", "R-HSA-72165", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Homologous_superfamily"}, "IPR043173": {"description": "Prp8 RNase domain IV, fingers region", "go_ids": [], "go_terms": [], "name": "Prp8_domainIV_fingers", "pathway_ids": ["R-HSA-72163", "R-CEL-72165", "R-MMU-72165", "R-MMU-72163", "R-HSA-72165", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Homologous_superfamily"}, "IPR043174": {"description": "Non-structural protein NSP15, middle domain superfamily", "go_ids": [], "go_terms": [], "name": "NSP15_middle_sf", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "PWY-7379", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-191859", "R-HSA-9705671", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7379:t:mRNA capping II", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR043175": {"description": "F-actin-capping protein subunit beta, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CAPZB_N", "pathway_ids": ["R-HSA-9013405", "R-HSA-2132295", "R-HSA-9662360", "R-HSA-9035034", "R-HSA-983231", "R-HSA-6807878", "R-HSA-3371497", "R-HSA-6811436"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Homologous_superfamily"}, "IPR043176": {"description": "NlpE, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "NlpE_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043177": {"description": "Papain-like protease, N-terminal domain superfamily, coronavirus", "go_ids": [], "go_terms": [], "name": "PLpro_N_sf_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR043178": {"description": "Papain-like protease, thumb domain superfamily, coronavirus", "go_ids": [], "go_terms": [], "name": "PLpro_thumb_sf_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR043179": {"description": "Major vault protein repeat domain 2 superfamily", "go_ids": [], "go_terms": [], "name": "Vault_2_sf", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Homologous_superfamily"}, "IPR043180": {"description": "Baseplate structural protein Gp11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Baseplate_struct_Gp11_C", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR043181": {"description": "Tymovirus endopeptidase domain", "go_ids": [], "go_terms": [], "name": "TYMV_endopept_dom", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7250", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Homologous_superfamily"}, "IPR043183": {"description": "DnaJ homolog subfamily B member 2/6-like", "go_ids": ["GO:0030544"], "go_terms": ["GO:0030544:Hsp70 protein binding:F"], "name": "DNJB2/6-like", "pathway_ids": ["R-RNO-3371453", "R-HSA-3371453", "R-MMU-3371453"], "pathways": ["R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Family"}, "IPR043184": {"description": "Extracellular matrix protein 2", "go_ids": [], "go_terms": [], "name": "ECM2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043185": {"description": "Net1/Tof2", "go_ids": ["GO:0000183"], "go_terms": ["GO:0000183:rDNA heterochromatin formation:P"], "name": "Net1/Tof2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043186": {"description": "Rhodanese-like domain-containing protein 14", "go_ids": [], "go_terms": [], "name": "Str14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043187": {"description": "Esterase CM06B1-like", "go_ids": [], "go_terms": [], "name": "CM06B1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043188": {"description": "Doublecortin domain-containing protein 1", "go_ids": ["GO:0008017", "GO:1902412"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:1902412:regulation of mitotic cytokinesis:P"], "name": "DCDC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043189": {"description": "Beta-1,4-glucuronyltransferase 1", "go_ids": ["GO:0015020", "GO:0009101"], "go_terms": ["GO:0015020:glucuronosyltransferase activity:F", "GO:0009101:glycoprotein biosynthetic process:P"], "name": "B4GAT1", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-5083627", "R-HSA-2022854", "R-MMU-9939291", "R-DRE-2022854", "R-BTA-2022854", "R-HSA-9939291", "R-BTA-9939291", "R-MMU-2022854", "R-DRE-9939291"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-5083627:r:Defective LARGE causes MDDGA6 and MDDGB6", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-DRE-2022854:r:Keratan sulfate biosynthesis", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-BTA-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-DRE-9939291:r:Matriglycan biosynthesis on DAG1"], "type": "Family"}, "IPR043193": {"description": "Glyoxalase domain-containing protein 4", "go_ids": [], "go_terms": [], "name": "GLOD4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043194": {"description": "Glyoxalase domain-containing protein 4, C-terminal", "go_ids": [], "go_terms": [], "name": "GLOD4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043195": {"description": "Tetratricopeptide repeat protein 12", "go_ids": [], "go_terms": [], "name": "TTC12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043197": {"description": "Plakin", "go_ids": ["GO:0045104"], "go_terms": ["GO:0045104:intermediate filament cytoskeleton organization:P"], "name": "Plakin", "pathway_ids": ["R-HSA-6798695", "R-HSA-6809371", "R-DRE-9696273", "R-HSA-8851680", "R-RNO-351906", "R-HSA-9013424", "R-HSA-351906", "R-DRE-9696264", "R-MMU-9013420", "R-DRE-6798695", "R-RNO-6805567", "R-HSA-446107", "R-HSA-6805567", "R-RNO-6809371", "R-HSA-9013420", "R-RNO-446107", "R-MMU-446107", "R-HSA-9696270", "R-DRE-6805567", 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"R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-DME-2025928:r:Calcineurin activates NFAT", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-2025928:r:Calcineurin activates NFAT", "R-RNO-4086398:r:Ca2+ pathway", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-CEL-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-BTA-4086398:r:Ca2+ pathway", "R-MMU-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-2025928:r:Calcineurin activates NFAT", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-2025928:r:Calcineurin activates NFAT", "R-CEL-4086398:r:Ca2+ pathway", "R-DME-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-HSA-4086398:r:Ca2+ pathway", "R-BTA-2025928:r:Calcineurin activates NFAT", "R-CEL-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-180024:r:DARPP-32 events", "R-DME-4086398:r:Ca2+ pathway"], "type": "Family"}, "IPR043365": {"description": "NACHT domain- and WD repeat-containing protein 1", "go_ids": [], "go_terms": [], "name": "NWD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043366": {"description": "HECTD4", "go_ids": [], "go_terms": [], "name": "HECTD4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043367": {"description": "Phospholipase A1 PLIP1/2/3, chloroplastic", "go_ids": ["GO:0008970"], "go_terms": ["GO:0008970:glycerophospholipid phospholipase A1 activity:F"], "name": "PLIP1/2/3", "pathway_ids": ["PWY-8051", "PWY-6803"], "pathways": ["PWY-8051:t:anandamide biosynthesis I", "PWY-6803:t:phosphatidylcholine acyl editing"], "type": "Family"}, "IPR043368": {"description": "Peptidyl-prolyl cis-trans isomerase FKBP3", "go_ids": [], "go_terms": [], "name": "FKBP3", "pathway_ids": 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{"description": "Reprimo family", "go_ids": [], "go_terms": [], "name": "Reprimo_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043384": {"description": "Reticulophagy receptor 1/3", "go_ids": ["GO:0061709"], "go_terms": ["GO:0061709:reticulophagy:P"], "name": "RETREG1/3", "pathway_ids": ["R-HSA-9920951"], "pathways": ["R-HSA-9920951:r:Dengue virus modulates apoptosis"], "type": "Family"}, "IPR043385": {"description": "Granule associated Rac and RHOG effector protein 1", "go_ids": [], "go_terms": [], "name": "GARRE1", "pathway_ids": ["R-HSA-9013423", "R-HSA-9013149", "R-HSA-9013408", "R-HSA-9013404"], "pathways": ["R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle"], "type": "Family"}, "IPR043387": {"description": "Insulin-like INSL3/INSL4", "go_ids": [], "go_terms": [], "name": "INSL3/INSL4", "pathway_ids": ["R-MMU-444821", "R-DME-110478", "R-BTA-418555", "R-CFA-444821", 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amino acid transport system permease protein LivM-like", "go_ids": ["GO:0015658"], "go_terms": ["GO:0015658:branched-chain amino acid transmembrane transporter activity:F"], "name": "LivM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043429": {"description": "ABC transporter membrane protein permease protein ArtM/GltK/GlnP/TcyL/YhdX-like", "go_ids": ["GO:0055085", "GO:0016020"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0016020:membrane:C"], "name": "ArtM/GltK/GlnP/TcyL/YhdX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043441": {"description": "Junction-associated protein Tjap1/BEGAIN", "go_ids": [], "go_terms": [], "name": "Tjap1/BEGAIN", "pathway_ids": ["R-HSA-6794361"], "pathways": ["R-HSA-6794361:r:Neurexins and neuroligins"], "type": "Family"}, "IPR043442": {"description": "PGC-1 and ERR-induced regulator in muscle protein 1", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], 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"pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043445": {"description": "TMEPAI family", "go_ids": ["GO:0070412", "GO:0030512"], "go_terms": ["GO:0070412:R-SMAD binding:F", "GO:0030512:negative regulation of transforming growth factor beta receptor signaling pathway:P"], "name": "TMEPAI/LRAD4", "pathway_ids": ["R-HSA-2173788", "R-MMU-2173788"], "pathways": ["R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling"], "type": "Family"}, "IPR043446": {"description": "Neurabin-like family", "go_ids": [], "go_terms": [], "name": "Neurabin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043447": {"description": "CCDC120/INAVA", "go_ids": [], "go_terms": [], "name": "CCDC120/INAVA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043448": {"description": "Pleckstrin homology domain-containing family O member 1/2", "go_ids": [], "go_terms": [], "name": "PKHO1/2", "pathway_ids": 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"R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9694635:r:Translation of Structural Proteins"], "type": "Homologous_superfamily"}, "IPR043477": {"description": "Peptidase C30, domain 3, coronavirus", "go_ids": [], "go_terms": [], "name": "Peptidase_C30_dom3_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage 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"R-CEL-5656169:r:Termination of translesion DNA synthesis", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-RNO-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-9684325:r:Maturation of replicase proteins", "R-DDI-69091:r:Polymerase switching", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-RNO-69091:r:Polymerase switching", "R-MMU-68952:r:DNA replication initiation", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-69091:r:Polymerase switching", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-MMU-69091:r:Polymerase switching", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR043503": {"description": "Papain-like viral protease, palm and finger domains, coronavirus", "go_ids": [], "go_terms": [], "name": "PLpro_palm_finger_dom_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Homologous_superfamily"}, "IPR043513": {"description": "Centromere protein Cenp-F", "go_ids": ["GO:0008017", "GO:0000775"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0000775:chromosome, centromeric region:C"], "name": "Cenp-F", "pathway_ids": ["R-HSA-141444", "R-HSA-5663220", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-9648025", "R-HSA-68877", "R-HSA-156711"], "pathways": ["R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-156711:r:Polo-like kinase mediated events"], "type": "Family"}, "IPR043519": {"description": "Nucleotidyltransferase superfamily", "go_ids": [], "go_terms": [], "name": "NT_sf", "pathway_ids": ["R-HSA-6798695", "R-BTA-110373", "R-XTR-9762293", "R-HSA-9833482", "R-BTA-5689880", "R-HSA-5689880", "R-HSA-6802952", "R-MMU-9770562", "R-DRE-110381", "R-HSA-73856", "R-DRE-110373", "R-RNO-110362", "R-HSA-72187", "R-SPO-9930044", "R-MMU-110381", "R-DRE-110362", "R-MMU-5689880", "R-MMU-9833482", "R-DRE-6798695", "R-MMU-9930044", "R-RNO-8983711", "R-HSA-429947", "R-MMU-5651801", "R-HSA-6784531", "R-HSA-110362", "R-BTA-73856", "R-MMU-73856", "R-BTA-110381", "R-RNO-5693571", "R-XTR-6798695", "R-RNO-5689880", "R-RNO-5649702", "R-SPO-9770562", "R-MMU-110373", "R-RNO-73930", "R-HSA-110381", "R-DRE-9762293", "R-RNO-110373", 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single-nucleotide replacement pathway", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DRE-9762293:r:Regulation of CDH11 gene transcription", "R-RNO-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-MMU-9762293:r:Regulation of CDH11 gene transcription", "R-MMU-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6785470:r:tRNA processing in the mitochondrion", "R-HSA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DDI-9930044:r:Nuclear RNA decay", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-9819196:r:Zygotic genome activation 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Long Patch Base Excision Repair", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-9762293:r:Regulation of CDH11 gene transcription", "R-BTA-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-MMU-8983711:r:OAS antiviral response", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-110373:r:Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-BTA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-9833482:r:PKR-mediated signaling", "R-XTR-9833482:r:PKR-mediated signaling", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-877300:r:Interferon gamma signaling", "R-RNO-9770562:r:mRNA Polyadenylation", "R-DRE-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DRE-73930:r:Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-9833482:r:PKR-mediated signaling"], "type": "Homologous_superfamily"}, "IPR043520": {"description": "Spermatogenesis-associated protein 21", "go_ids": ["GO:0005509"], "go_terms": ["GO:0005509:calcium ion binding:F"], "name": "SPT21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043521": {"description": "Tumor necrosis factor receptor 13C/17", "go_ids": ["GO:0038023", "GO:0033209"], "go_terms": ["GO:0038023:signaling receptor activity:F", "GO:0033209:tumor necrosis factor-mediated signaling pathway:P"], "name": "TNFR_13C/17", "pathway_ids": ["R-HSA-5668541", "R-HSA-5669034", "R-MMU-5669034", "R-MMU-5676594", "R-MMU-5668541", "R-HSA-5676594"], "pathways": ["R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "type": "Family"}, "IPR043522": {"description": "DNA damage-induced apoptosis suppressor protein", "go_ids": ["GO:1902230"], "go_terms": ["GO:1902230:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage:P"], "name": "DDIAS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043529": {"description": "Alpha-protein kinase 1", "go_ids": ["GO:0004674"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F"], "name": "ALPK1", "pathway_ids": ["R-HSA-9645460", "R-MMU-445989", "R-HSA-445989", "R-MMU-9645460"], "pathways": ["R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway"], "type": "Family"}, "IPR043530": {"description": "HLA class II histocompatibility antigen, gamma subunit", "go_ids": ["GO:0042289", "GO:0035718"], "go_terms": ["GO:0042289:MHC class II protein binding:F", "GO:0035718:macrophage migration inhibitory factor binding:F"], "name": "CD74_antigen", "pathway_ids": ["R-HSA-9925563", "R-RNO-2132295", "R-HSA-2132295", "R-RNO-202733", "R-MMU-202733", "R-MMU-2132295", "R-HSA-202733"], "pathways": ["R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR043531": {"description": "E3 SUMO-protein ligase CBX4", "go_ids": ["GO:0045892"], "go_terms": ["GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "CBX4", "pathway_ids": ["R-HSA-4655427", "R-MMU-4551638", "R-HSA-8939243", "R-HSA-3108214", "R-HSA-2559580", "R-MMU-3899300", "R-HSA-8943724", "R-HSA-4570464", "R-MMU-4570464", "R-MMU-3108214", "R-HSA-3899300", "R-HSA-4551638", "R-MMU-8939243", "R-MMU-8943724"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-8943724:r:Regulation of PTEN gene transcription"], "type": "Family"}, "IPR043534": {"description": "Exo-beta-D-glucosaminidase/Endo-beta-mannosidase", "go_ids": ["GO:0004553"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "EBDG/EBM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043535": {"description": "Tubulin epsilon and delta complex protein 1", "go_ids": [], "go_terms": [], "name": "TEDC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043536": {"description": "Host cell factor", "go_ids": [], "go_terms": [], "name": "HCF1/2", "pathway_ids": ["R-MMU-3214847", "R-RNO-5689603", "R-RNO-3214847", "R-HSA-2151201", "R-DME-9772755", "R-DME-3214847", "R-RNO-9772755", "R-HSA-9772755", "R-DME-5689603", "R-CEL-9772755", "R-HSA-3214847", "R-HSA-5689603", "R-MMU-9772755", "R-MMU-5689603"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-RNO-5689603:r:UCH proteinases", "R-RNO-3214847:r:HATs acetylate histones", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-3214847:r:HATs acetylate histones", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-5689603:r:UCH proteinases", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5689603:r:UCH proteinases"], "type": "Family"}, "IPR043537": {"description": "Tiam1/Tiam2/Protein still life", "go_ids": ["GO:0005085", "GO:0090630", "GO:0007264"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0090630:activation of GTPase activity:P", "GO:0007264:small GTPase-mediated signal transduction:P"], "name": "Tiam1/Tiam2/Sif", "pathway_ids": ["R-HSA-1989781", "R-DME-9013149", "R-HSA-193648", "R-DME-8980692", "R-MMU-3928665", "R-MMU-8980692", "R-DME-3928662", "R-HSA-416482", "R-MMU-9013148", "R-MMU-9013404", "R-HSA-3928662", "R-HSA-9013404", "R-HSA-9013423", "R-MMU-9013423", "R-HSA-9013149", "R-DME-9013148", "R-HSA-8980692", "R-HSA-3928665", "R-DME-193648", "R-MMU-416482", "R-DME-416482", "R-HSA-9013148", 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"R-DME-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR043538": {"description": "Xylosyltransferase", "go_ids": ["GO:0030158", "GO:0030166"], "go_terms": ["GO:0030158:protein xylosyltransferase activity:F", "GO:0030166:proteoglycan biosynthetic process:P"], "name": "XYLT", "pathway_ids": ["PWY-6557", "R-HSA-1971475", "R-CFA-1971475", "R-CEL-1971475", "R-RNO-1971475", "R-MMU-1971475", "R-DME-1971475"], "pathways": ["PWY-6557:t:glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-CFA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", 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"R-RNO-2730905", "R-MMU-1963642", "R-MMU-5654712", "R-CEL-6811558", "R-DME-1963642", "R-RNO-9013420", "R-HSA-179812", "R-XTR-74749", "R-RNO-5654712", "R-HSA-8865999", "R-HSA-9680350", "R-RNO-2871796", "R-RNO-5654699", "R-XTR-180292", "R-DME-180336", "R-XTR-5654706", "R-HSA-202433", "R-RNO-1257604", "R-CEL-5654720", "R-XTR-210993", "R-CEL-2179392", "R-RNO-5654727", "R-RNO-167044", "R-RNO-5654719", "R-XTR-5673001", "R-RNO-389359", "R-CEL-5654712", "R-MMU-5654704", "R-HSA-1963642", "R-RNO-8856828", "R-XTR-5654727", "R-HSA-9706369", "R-CEL-8856828", "R-HSA-5655332", "R-XTR-6811558", "R-HSA-5654726", "R-DME-5654719", "R-HSA-109704", "R-DME-2179392", "R-HSA-2871809", "R-HSA-9034864", "R-MMU-354194", "R-HSA-6807004", "R-HSA-74749", "R-HSA-9842663", "R-MMU-1257604", "R-RNO-5654689", "R-DME-2730905", "R-HSA-180336", "R-DME-74749", "R-XTR-5654732", "R-DME-5654712", "R-CEL-179812", "R-HSA-8856825", "R-MMU-5654727", "R-MMU-8851907", "R-RNO-983695", "R-RNO-5654733", "R-DME-186763", "R-XTR-5654689", 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"R-MMU-8875555", "R-DME-5654710", "R-HSA-9703648", "R-HSA-5654720", "R-DME-1963640", "R-RNO-8875555", "R-HSA-9674555", "R-RNO-9028731", "R-HSA-5654733", "R-HSA-5654704", "R-MMU-5654688", "R-XTR-8851907", "R-XTR-167044", "R-MMU-375165", "R-CEL-375165", "R-XTR-2871796", "R-DME-5654720", "R-MMU-8856825", "R-RNO-354194", "R-DME-6811558", "R-DME-2871809", "R-HSA-1236382", "R-XTR-5654710", "R-DME-8856828", "R-MMU-5654719", "R-XTR-8875656", "R-HSA-9028731", "R-XTR-8851805", "R-DME-8856825", "R-XTR-5654712", "R-MMU-202433", "R-HSA-9013420", "R-CEL-6807004", "R-RNO-1963640", "R-XTR-186763", "R-HSA-354194", "R-HSA-9679191", "R-MMU-983695", "R-HSA-1433557", "R-RNO-180292", "R-CEL-180336", "R-CEL-2029482", "R-HSA-9703465", "R-MMU-2871809", "R-CEL-1963642", "R-XTR-8853659", "R-RNO-5654720", "R-MMU-2424491", "R-DME-5654726", "R-RNO-186763", "R-XTR-375165", "R-CEL-5654704", "R-XTR-6807004"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-XTR-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-XTR-112412:r:SOS-mediated signalling", "R-XTR-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-RNO-912631:r:Regulation of signaling by CBL", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-CEL-9607240:r:FLT3 Signaling", "R-XTR-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-XTR-1433557:r:Signaling by SCF-KIT", "R-CEL-182971:r:EGFR downregulation", "R-MMU-186763:r:Downstream signal transduction", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-5663213:r:RHO GTPases 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"R-CEL-6807004:r:Negative regulation of MET activity", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-XTR-186763:r:Downstream signal transduction", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-RNO-180292:r:GAB1 signalosome", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-XTR-8853659:r:RET signaling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-MMU-2424491:r:DAP12 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-186763:r:Downstream signal transduction", "R-XTR-375165:r:NCAM signaling for neurite out-growth", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-XTR-6807004:r:Negative regulation of MET activity"], "type": "Family"}, "IPR043540": {"description": "E3 ubiquitin-protein ligase RING1/RING2", "go_ids": ["GO:0000151"], "go_terms": ["GO:0000151:ubiquitin ligase complex:C"], "name": "RING1/RING2", "pathway_ids": ["PWY-7511", "R-HSA-4655427", "R-MMU-8953750", "R-DME-8939243", "R-RNO-8943724", "R-HSA-3108214", "R-HSA-2559580", "R-CFA-8939243", "R-DRE-2559580", "R-MMU-4570464", "R-RNO-8953750", "R-DRE-8953750", "R-RNO-3108214", "R-DRE-8939243", "R-HSA-8953750", "R-RNO-8939243", "R-DRE-4570464", "R-DME-2559580", "R-DRE-3108214", "R-MMU-4551638", "R-DME-4570464", "R-CFA-8943724", "R-HSA-8943724", "R-DME-3899300", "R-HSA-4570464", "R-DME-8953750", "R-HSA-4551638", "R-DME-3108214", "R-RNO-3899300", "R-MMU-3899300", "R-MMU-8939243", "R-DRE-3899300", "R-MMU-8943724", "R-RNO-4551638", "R-HSA-8939243", "R-RNO-2559580", "R-RNO-4570464", "R-CFA-2559580", "R-MMU-3108214", "R-HSA-3899300", "R-DME-8943724", "R-CFA-8953750"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-8943724:r:Regulation of PTEN gene transcription", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-CFA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-4570464:r:SUMOylation of RNA binding proteins", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-CFA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-CFA-8953750:r:Transcriptional Regulation by E2F6"], "type": "Family"}, "IPR043541": {"description": "Synaptotagmin-14/14L/16", "go_ids": [], "go_terms": [], "name": "SYT14/14L/16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043543": {"description": "Pappalysin-1/2", "go_ids": [], "go_terms": [], "name": "PAPPA/PAPPA2", "pathway_ids": ["R-MMU-381426", "R-HSA-381426"], "pathways": ["R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR043544": {"description": "Sorting nexin-10/11", "go_ids": ["GO:0006886"], "go_terms": ["GO:0006886:intracellular protein transport:P"], "name": "SNX10/11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043545": {"description": "Glutamate receptor-interacting protein 1/2", "go_ids": [], "go_terms": [], "name": "GRIP1/2", "pathway_ids": ["R-HSA-416993", "R-RNO-416993", "R-MMU-416993"], "pathways": ["R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors"], "type": "Family"}, "IPR043546": {"description": "Vesicle-trafficking protein Sec22a/c", "go_ids": ["GO:0006888"], "go_terms": ["GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P"], "name": "Sec22a/c", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-BTA-204005", "R-RNO-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-RNO-204005:r:COPII-mediated vesicle transport"], "type": "Family"}, "IPR043547": {"description": "Mimecan/Epiphycan/Opticin", "go_ids": [], "go_terms": [], "name": "Mimecan/Epiphycan/Opticin", "pathway_ids": ["R-HSA-1474228", "R-MMU-2022857", "R-HSA-3656244", "R-GGA-2022854", "R-HSA-2022854", "R-HSA-3656243", "R-HSA-3656225", "R-BTA-1474228", "R-BTA-2022854", "R-HSA-2022857", "R-GGA-2022857", "R-MMU-2022854", "R-BTA-2022857", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-GGA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-GGA-2022857:r:Keratan sulfate degradation", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-BTA-2022857:r:Keratan sulfate degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Family"}, "IPR043548": {"description": "1-phosphatidylinositol-3phosphate-5-kinase", "go_ids": ["GO:0000285"], "go_terms": ["GO:0000285:1-phosphatidylinositol-3-phosphate 5-kinase activity:F"], "name": "PIKfyve", "pathway_ids": ["R-HSA-1660517", "R-MMU-1660517", "R-HSA-1660514", "R-MMU-1660516", "R-HSA-1660516", "R-MMU-1660514"], "pathways": ["R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane"], "type": "Family"}, "IPR043549": {"description": "C2 calcium-dependent domain-containing protein 4C/4D", "go_ids": [], "go_terms": [], "name": "C2C4C/C2C4D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043550": {"description": "Histone-lysine N-methyltransferase EHMT1/EHMT2", "go_ids": ["GO:0002039", "GO:0042054", "GO:0016279"], "go_terms": ["GO:0002039:p53 binding:F", "GO:0042054:histone methyltransferase activity:F", "GO:0016279:protein-lysine N-methyltransferase activity:F"], "name": "EHMT1/EHMT2", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-8853884", "R-MMU-6804760", "R-MMU-8953750", "R-MMU-73762", "R-MMU-3214841", "R-HSA-3214841", "R-HSA-9843970", "R-HSA-6804760", "R-HSA-427389", "R-MMU-2559582", "R-HSA-73762", "R-HSA-2559582", "R-HSA-8953750"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-8953750:r:Transcriptional Regulation by E2F6"], "type": "Family"}, "IPR043554": {"description": "SNF1-related protein kinase regulatory subunit beta", "go_ids": [], "go_terms": [], "name": "KINB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043555": {"description": "Sushi repeat-containing protein SRPX-like", "go_ids": [], "go_terms": [], "name": "SRPX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043556": {"description": "StAR-related lipid transfer protein 5/6", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "StARD5/6", "pathway_ids": ["R-MMU-196108", "R-HSA-159418", "R-HSA-196108", "R-BTA-159418", "R-MMU-159418"], "pathways": ["R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-BTA-159418:r:Recycling of bile acids and salts", "R-MMU-159418:r:Recycling of bile acids and salts"], "type": "Family"}, "IPR043557": {"description": "Dermcidin/Lacritin", "go_ids": [], "go_terms": [], "name": "Dermcidin/Lacritin", "pathway_ids": ["R-HSA-6803157"], "pathways": ["R-HSA-6803157:r:Antimicrobial peptides"], "type": "Family"}, "IPR043561": {"description": "Transcription factor LHW-like", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "LHW-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043562": {"description": "Retinal homeobox protein RAX/RAX2", "go_ids": ["GO:0000981", "GO:0045944"], "go_terms": ["GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific:F", "GO:0045944:positive regulation of transcription by RNA polymerase II:P"], "name": "RAX/RAX2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043563": {"description": "Nuclear body protein Sp110/Sp140/Sp140L-like", "go_ids": [], "go_terms": [], "name": "Sp110/Sp140/Sp140L-like", "pathway_ids": ["R-HSA-3108214", "R-HSA-877300"], "pathways": ["R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-877300:r:Interferon gamma signaling"], "type": "Family"}, "IPR043565": {"description": "PAX family", "go_ids": ["GO:0003677", 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"R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-DME-3214847:r:HATs acetylate histones", "R-HSA-9761174:r:Formation of intermediate mesoderm", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9834899:r:Specification of the neural plate border", "R-HSA-210746:r:Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Family"}, "IPR043566": {"description": "Rabphilin/Doc2/Noc2", "go_ids": [], "go_terms": [], "name": "Rabphilin/DOC2/Noc2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043573": {"description": "Polyphosphoinositide phosphatase Fig4-like", "go_ids": ["GO:0043813", "GO:0046856"], 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"R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-4641257:r:Degradation of AXIN"], "type": "Family"}, "IPR043582": {"description": "Calcium 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"go_terms": ["GO:0030600:feruloyl esterase activity:F"], "name": "FaeB/C/D", "pathway_ids": ["PWY-6784"], "pathways": ["PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)"], "type": "Family"}, "IPR043596": {"description": "CFAP53/TCHP", "go_ids": [], "go_terms": [], "name": "CFAP53/TCHP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043597": {"description": "Trichohyalin-plectin-homology domain", "go_ids": [], "go_terms": [], "name": "TPH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043601": {"description": "R-spondin, Fu-CRD domain", "go_ids": [], "go_terms": [], "name": "Rspo_Fu-CRD_dom", "pathway_ids": ["R-XTR-4641263", "R-HSA-8939256", "R-MMU-4641263", "R-RNO-167060", "R-HSA-4641263", "R-DRE-4641263", "R-RNO-8963889", "R-BTA-4641263"], "pathways": ["R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-MMU-4641263:r:Regulation of FZD by 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"R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR043607": {"description": "Coronavirus spike glycoprotein S1, C-terminal", "go_ids": [], "go_terms": [], "name": "CoV_S1_C", "pathway_ids": ["R-HSA-9679509", "R-HSA-9683686", "R-HSA-9705671", "R-HSA-9733458", "R-HSA-9678110", "R-HSA-9683701", "R-HSA-9694548", "R-HSA-9692916", "R-HSA-166662", "R-HSA-166663", "R-HSA-9694614", "R-HSA-9694322", "R-HSA-9694635"], "pathways": ["R-HSA-9679509:r:Virion Assembly and Release", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-HSA-9678110:r:Attachment and Entry", "R-HSA-9683701:r:Translation of Structural Proteins", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-9694322:r:Virion Assembly and Release", "R-HSA-9694635:r:Translation of Structural Proteins"], "type": "Domain"}, "IPR043608": {"description": "Nonstructural protein 15, middle domain, coronavirus", "go_ids": [], 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"R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR043609": {"description": "NendoU domain, nidovirus", "go_ids": [], "go_terms": [], "name": 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responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR043612": {"description": "Non-structural protein NSP4, N-terminal, coronavirus", "go_ids": [], "go_terms": [], "name": "CoV_NSP4_N", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", 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"R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 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"NSP2_N_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-9705671", "R-HSA-191859", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR043628": {"description": "DAZ domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "DAZ_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043629": {"description": "Salyut domain", "go_ids": [], "go_terms": [], "name": "Salyut_dom", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7250", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR043630": {"description": "Sgo0707, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Sgo0707_N1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043631": {"description": "QPE repeat", "go_ids": [], "go_terms": [], "name": "QPE_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR043636": {"description": "L1 transposable element, RRM domain", "go_ids": [], "go_terms": [], "name": "L1_RRM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043637": {"description": "Spo16 protein, N-terminal domain", "go_ids": ["GO:0000217", "GO:0010520", "GO:0007130"], "go_terms": ["GO:0000217:DNA secondary structure binding:F", "GO:0010520:regulation of reciprocal meiotic recombination:P", "GO:0007130:synaptonemal complex assembly:P"], "name": "Spo16_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043638": {"description": "DisA glycoprotein", "go_ids": [], "go_terms": [], "name": "DisA_glycoprotein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043639": {"description": "AF4 interaction motif", "go_ids": [], "go_terms": [], "name": "AF4_int", "pathway_ids": ["R-MMU-75955", "R-HSA-674695", "R-HSA-112382", "R-HSA-75955", "R-MMU-674695", "R-MMU-112382"], "pathways": ["R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex"], "type": "Conserved_site"}, "IPR043640": {"description": "AF4/FMR2, C-terminal homology domain", "go_ids": ["GO:0005634"], "go_terms": ["GO:0005634:nucleus:C"], "name": "AF4/FMR2_CHD", "pathway_ids": ["R-DME-112382", "R-HSA-112382", "R-DME-674695", "R-HSA-75955", "R-MMU-75955", "R-HSA-674695", "R-DME-75955", "R-MMU-674695", "R-MMU-112382"], "pathways": ["R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR043641": {"description": "PPE-PPW subfamily, C-terminal", "go_ids": [], "go_terms": [], "name": "PPE-PPW_C", "pathway_ids": ["R-HSA-9636249"], "pathways": ["R-HSA-9636249:r:Inhibition of nitric oxide production"], "type": "Domain"}, "IPR043645": {"description": "Peripherally associated ATOM36", "go_ids": [], "go_terms": [], "name": "pATOM36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043646": {"description": "Chroparavirus methyltransferase domain", "go_ids": [], "go_terms": [], "name": "Chropara_Vmeth_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043647": {"description": "Nodavirus methyltransferase domain", "go_ids": [], "go_terms": [], "name": "Noda_Vmethyltr_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043651": {"description": "KNL1 MELT repeat", "go_ids": ["GO:0051301"], "go_terms": ["GO:0051301:cell division:P"], "name": "KNL1_MELT_rpt", "pathway_ids": ["R-HSA-606279", "R-HSA-141444", "R-HSA-5663220", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-9648025", "R-HSA-68877"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-68877:r:Mitotic Prometaphase"], "type": "Repeat"}, "IPR043652": {"description": "Crescentin, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CreS_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043653": {"description": "Domain of unknown function DUF5880", "go_ids": [], "go_terms": [], "name": "DUF5880", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043654": {"description": "Protein of unknown function DUF5879", "go_ids": [], "go_terms": [], "name": "DUF5879", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043655": {"description": "Domain of unknown function DUF5878", "go_ids": [], "go_terms": [], "name": "DUF5878", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043656": {"description": "Protein of unknown function DUF5877", "go_ids": [], "go_terms": [], "name": "DUF5877", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043657": {"description": "Protein of unknown function DUF5876", "go_ids": [], "go_terms": [], "name": "DUF5876", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043658": {"description": "Protein of unknown function DUF5875", "go_ids": [], "go_terms": [], "name": "DUF5875", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043659": {"description": "Exolysin-like, DUF5874", "go_ids": [], "go_terms": [], "name": "Exolysin_DUF5874", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043660": {"description": "Domain of unknown function DUF5873", "go_ids": [], "go_terms": [], "name": "DUF5873", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043677": {"description": "D-allulose-6-phosphate 3-epimerase", "go_ids": ["GO:0034700", "GO:0046872"], "go_terms": ["GO:0034700:allulose 6-phosphate 3-epimerase activity:F", "GO:0046872:metal ion binding:F"], "name": "AlluloseP_3_epimer_AlsE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043691": {"description": "Murein peptide amidase A", "go_ids": ["GO:0009253", "GO:0004040", "GO:0008270"], "go_terms": ["GO:0009253:peptidoglycan catabolic process:P", "GO:0004040:amidase activity:F", "GO:0008270:zinc ion binding:F"], "name": "MpaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043692": {"description": "Ubiquinone biosynthesis protein UbiU", "go_ids": ["GO:0006744"], "go_terms": ["GO:0006744:ubiquinone biosynthetic process:P"], "name": "UbiU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043693": {"description": "Ubiquinone biosynthesis protein UbiV", "go_ids": ["GO:0006744"], "go_terms": ["GO:0006744:ubiquinone biosynthetic process:P"], "name": "UbiV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043697": {"description": "N-acetyl-L-citrulline deacetylase ArgE'-like", "go_ids": ["GO:0006526", "GO:0019213"], "go_terms": ["GO:0006526:L-arginine biosynthetic process:P", "GO:0019213:deacetylase activity:F"], "name": "ACDase_ArgE'-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043698": {"description": "Racemase Bsr/Lyr", "go_ids": ["GO:0016853"], "go_terms": ["GO:0016853:isomerase activity:F"], "name": "Racemase_Bsr/Lyr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043705": {"description": "Plasmodium repeat of length 46", "go_ids": [], "go_terms": [], "name": "P_repeat_46", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR043706": {"description": "Protein of unknown function DUF5646", "go_ids": [], "go_terms": [], "name": "DUF5646", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043707": {"description": "Protein of unknown function DUF5647", "go_ids": [], "go_terms": [], "name": "DUF5647", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043708": {"description": "Domain of unknown function DUF5648", "go_ids": [], "go_terms": [], "name": "DUF5648", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043709": {"description": "Repeats of unknown function DUF5649", "go_ids": [], "go_terms": [], "name": "DUF5649", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR043710": {"description": "Repeat of unknown function DUF5650", "go_ids": [], "go_terms": [], "name": "DUF5650", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR043711": {"description": "Domain of unknown function DUF5651", "go_ids": [], "go_terms": [], "name": "DUF5651", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043712": {"description": "Domain of unknown function DUF5652", "go_ids": [], "go_terms": [], "name": "DUF5652", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043713": {"description": "Family of unknown function DUF5654", "go_ids": [], "go_terms": [], "name": "DUF5654", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043714": {"description": "Domain of unknown function DUF5655", "go_ids": [], "go_terms": [], "name": "DUF5655", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043715": {"description": "Protein of unknown function DUF5656", "go_ids": [], "go_terms": [], "name": "DUF5656", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043716": {"description": "Family of unknown function DUF5657", "go_ids": [], "go_terms": [], "name": "DUF5657", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043717": {"description": "Domain of unknown function DUF5658", "go_ids": [], "go_terms": [], "name": "DUF5658", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043718": {"description": "Domain of unknown function DUF5659", "go_ids": [], "go_terms": [], "name": "DUF5659", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043719": {"description": "Domain of unknown function DUF5660", "go_ids": [], "go_terms": [], "name": "DUF5660", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043720": {"description": "Domain of unknown function DUF5661", "go_ids": [], "go_terms": [], "name": "DUF5661", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043721": {"description": "Family of unknown function DUF5662", "go_ids": [], "go_terms": [], "name": "DUF5662", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043722": {"description": "Protein of unknown function DUF5663", "go_ids": [], "go_terms": [], "name": "DUF5663", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043723": {"description": "Protein of unknown function DUF5665", "go_ids": [], "go_terms": [], "name": "DUF5665", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043724": {"description": "Domain of unknown function DUF5666", "go_ids": [], "go_terms": [], "name": "DUF5666", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043725": {"description": "Domain of unknown function DUF5667", "go_ids": [], "go_terms": [], "name": "DUF5667", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043726": {"description": "LiaI-LiaF-like transmembrane region", "go_ids": [], "go_terms": [], "name": "LiaI-LiaF-like_TM1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043727": {"description": "Lmo0937-like", "go_ids": [], "go_terms": [], "name": "Lmo0937-like", "pathway_ids": [], 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"DUF5677", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043734": {"description": "Domain of unknown function DUF5678", "go_ids": [], "go_terms": [], "name": "DUF5678", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043735": {"description": "Domain of unknown function DUF5680", "go_ids": [], "go_terms": [], "name": "DUF5680", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043736": {"description": "Domain of unknown function DUF5681", "go_ids": [], "go_terms": [], "name": "DUF5681", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043737": {"description": "Family of unknown function DUF5682", "go_ids": [], "go_terms": [], "name": "DUF5682", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043738": {"description": "Domain of unknown function DUF5683", "go_ids": [], "go_terms": [], "name": "DUF5683", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043739": {"description": "Family of unknown function DUF5684", "go_ids": [], 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unknown function DUF5696", "go_ids": [], "go_terms": [], "name": "DUF5696", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043752": {"description": "Family of unknown function DUF5697", "go_ids": [], "go_terms": [], "name": "DUF5697", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043753": {"description": "Protein of unknown function DUF5699", "go_ids": [], "go_terms": [], "name": "DUF5699", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043754": {"description": "Putative zinc dependent peptidase DUF5700", "go_ids": [], "go_terms": [], "name": "DUF5700", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043755": {"description": "Protein of unknown function DUF5701", "go_ids": [], "go_terms": [], "name": "DUF5701", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043756": {"description": "Protein of unknown function DUF5702", "go_ids": [], "go_terms": [], "name": "DUF5702", "pathway_ids": [], "pathways": [], "type": "Family"}, 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DUF5803", "go_ids": [], "go_terms": [], "name": "DUF5803", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043827": {"description": "Protein of unknown function DUF5804", "go_ids": [], "go_terms": [], "name": "DUF5804", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043828": {"description": "Protein of unknown function DUF5805", "go_ids": [], "go_terms": [], "name": "DUF5805", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043829": {"description": "Protein of unknown function DUF5806", "go_ids": [], "go_terms": [], "name": "DUF5806", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043830": {"description": "Protein of unknown function DUF5807", "go_ids": [], "go_terms": [], "name": "DUF5807", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043831": {"description": "Domain of unknown function DUF5808", "go_ids": [], "go_terms": [], "name": "DUF5808", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043832": {"description": 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"IPR043844": {"description": "Domain of unknown function DUF5865", "go_ids": [], "go_terms": [], "name": "DUF5865", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043845": {"description": "Protein of unknown function DUF5864", "go_ids": [], "go_terms": [], "name": "DUF5864", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043846": {"description": "Protein of unknown function DUF5863", "go_ids": [], "go_terms": [], "name": "DUF5863", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043847": {"description": "Domain of unknown function DUF5862", "go_ids": [], "go_terms": [], "name": "DUF5862", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043848": {"description": "Domain of unknown function DUF5860", "go_ids": [], "go_terms": [], "name": "DUF5860", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043849": {"description": "Protein of unknown function DUF5859", "go_ids": [], "go_terms": [], "name": "DUF5859", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043850": {"description": "Protein of unknown function DUF5812", "go_ids": [], "go_terms": [], "name": "DUF5812", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043851": {"description": "Protein of unknown function DUF5813", "go_ids": [], "go_terms": [], "name": "DUF5813", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043852": {"description": "Protein of unknown function DUF5814", "go_ids": [], "go_terms": [], "name": "DUF5814", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043853": {"description": "Protein of unknown function DUF5815", "go_ids": [], "go_terms": [], "name": "DUF5815", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043854": {"description": "Protein of unknown function DUF5816", "go_ids": [], "go_terms": [], "name": "DUF5816", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043855": {"description": "Domain of unknown function DUF5817", "go_ids": [], "go_terms": [], "name": "DUF5817", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043856": {"description": "Protein of unknown function DUF5818", "go_ids": [], "go_terms": [], "name": "DUF5818", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043857": {"description": "Protein of unknown function DUF5819", "go_ids": [], "go_terms": [], "name": "DUF5819", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043858": {"description": "Protein of unknown function DUF5820", "go_ids": [], "go_terms": [], "name": "DUF5820", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043859": {"description": "Transcriptional regulator TbsP, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TbsP-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043860": {"description": "Protein of unknown function DUF5822", "go_ids": [], "go_terms": [], "name": "DUF5822", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043861": {"description": "Protein of unknown function DUF5823", "go_ids": [], "go_terms": [], "name": "DUF5823", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043862": {"description": "Domain of unknown function DUF5824", "go_ids": [], "go_terms": [], "name": "DUF5824", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043863": {"description": "Protein of unknown function DUF5825", "go_ids": [], "go_terms": [], "name": "DUF5825", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043864": {"description": "OMP85-like, membrane spanning beta-barrel domain", "go_ids": [], "go_terms": [], "name": "Omp85-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043866": {"description": "E3 ubiquitin-protein ligase TTC3/DZIP3 domain", "go_ids": [], "go_terms": [], "name": "TTC3/DZIP3_dom", "pathway_ids": ["PWY-7511", "R-HSA-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR043867": {"description": "Protein of unknown function DUF5827", "go_ids": [], "go_terms": [], "name": "DUF5827", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043868": {"description": "Protein of unknown function DUF5828", "go_ids": [], "go_terms": [], "name": "DUF5828", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043869": {"description": "Protein of unknown function DUF5829", "go_ids": [], "go_terms": [], "name": "DUF5829", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043870": {"description": "Protein of unknown function DUF5830", "go_ids": [], "go_terms": [], "name": "DUF5830", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043871": {"description": "Protein of unknown function DUF5831", "go_ids": [], "go_terms": [], "name": "DUF5831", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043872": {"description": "Protein of unknown function DUF5832", "go_ids": [], "go_terms": [], "name": "DUF5832", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043873": {"description": "Domain of unknown function DUF5858", "go_ids": [], "go_terms": [], "name": "DUF5858", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043874": {"description": "Protein of unknown function DUF5834", "go_ids": [], "go_terms": [], "name": "DUF5834", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043875": {"description": "Domain of unknown function DUF5857", "go_ids": [], "go_terms": [], "name": "DUF5857", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043876": {"description": "Protein of unknown function DUF5856", "go_ids": [], "go_terms": [], "name": "DUF5856", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043877": {"description": "Domain of unknown function DUF5855", "go_ids": [], "go_terms": [], "name": "DUF5855", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043878": {"description": "Protein of unknown function DUF5854", "go_ids": [], "go_terms": [], "name": "DUF5854", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043879": {"description": "Domain of unknown function DUF5853", "go_ids": [], "go_terms": [], "name": "DUF5853", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043880": {"description": "Protein of unknown function DUF5852", "go_ids": [], "go_terms": [], "name": "DUF5852", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043881": {"description": "Protein of unknown function DUF5851", "go_ids": [], "go_terms": [], "name": "DUF5851", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043882": {"description": "Protein of unknown function DUF5850", "go_ids": [], "go_terms": [], "name": "DUF5850", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043883": {"description": "Protein of unknown function DUF5849", "go_ids": [], "go_terms": [], "name": "DUF5849", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043884": {"description": "Domain of unknown function DUF5848", "go_ids": [], "go_terms": [], "name": "DUF5848", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043885": {"description": "Protein of unknown function DUF5847", "go_ids": [], "go_terms": [], "name": "DUF5847", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043886": {"description": "Protein of unknown function DUF5846", "go_ids": [], "go_terms": [], "name": "DUF5846", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043887": {"description": "Protein of unknown function DUF5845", "go_ids": [], "go_terms": [], "name": "DUF5845", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043888": {"description": "Protein of unknown function DUF5844", "go_ids": [], "go_terms": [], "name": "DUF5844", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043889": {"description": "Protein of unknown function DUF5843", "go_ids": [], "go_terms": [], "name": "DUF5843", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043891": {"description": "SPARK domain", "go_ids": [], "go_terms": [], "name": "SPARK", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043892": {"description": "Protein of unknown function DUF5841", "go_ids": [], "go_terms": [], "name": "DUF5841", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043894": {"description": "6-phospho-N-acetylmuramidase, C-terminal", "go_ids": [], "go_terms": [], "name": "MupG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043895": {"description": "Protein of unknown function DUF5839", "go_ids": [], "go_terms": [], "name": "DUF5839", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043896": {"description": "AbpIP induction peptide", "go_ids": [], "go_terms": [], "name": "AbpIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043897": {"description": "Protein of unknown function DUF5835", "go_ids": [], "go_terms": [], "name": "DUF5835", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043898": {"description": "FANCL, UBC-like domain 2", "go_ids": [], "go_terms": [], "name": "FANCL_d2", "pathway_ids": ["PWY-7511", "R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR043899": {"description": "Protein of unknown function DUF5789", "go_ids": [], "go_terms": [], "name": "DUF5789", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043900": {"description": "Protein of unknown function DUF5788", "go_ids": [], "go_terms": [], "name": "DUF5788", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043901": {"description": "Protein of unknown function DUF5787", "go_ids": [], "go_terms": [], "name": "DUF5787", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043902": {"description": "Domain of unknown function DUF5786", "go_ids": [], "go_terms": [], "name": "DUF5786", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043903": {"description": "Protein of unknown function DUF5785", "go_ids": [], "go_terms": [], "name": "DUF5785", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043904": {"description": "PhoD-like phosphatase", "go_ids": [], "go_terms": [], "name": "PhoD_2-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043905": {"description": "Protein of unknown function DUF5771", "go_ids": [], "go_terms": [], "name": "DUF5771", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043906": {"description": "Gfo/Idh/MocA-like oxidoreductase, bacterial type, C-terminal", "go_ids": [], "go_terms": [], "name": "Gfo/Idh/MocA_OxRdtase_bact_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043907": {"description": "Protein of unknown function DUF5770", "go_ids": [], "go_terms": [], "name": "DUF5770", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043908": {"description": "Protein of unknown function DUF5769", "go_ids": [], "go_terms": [], "name": "DUF5769", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043909": {"description": "Protein of unknown function DUF5768", "go_ids": [], "go_terms": [], "name": "DUF5768", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043910": {"description": "Protein of unknown function DUF5767", "go_ids": [], "go_terms": [], "name": "DUF5767", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043911": {"description": "Protein of unknown function DUF5766", "go_ids": [], "go_terms": [], "name": "DUF5766", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043912": {"description": "Protein of unknown function DUF5765", "go_ids": [], "go_terms": [], "name": "DUF5765", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043913": {"description": "Protein of unknown function DUF5764", "go_ids": [], "go_terms": [], "name": "DUF5764", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043914": {"description": "Domain of unknown function DUF5763", "go_ids": [], "go_terms": [], "name": "DUF5763", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043915": {"description": "Minor capsid protein P9 transmembrane helices", "go_ids": [], "go_terms": [], "name": "P9_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043916": {"description": "Minor capsid protein P8, central region", "go_ids": [], "go_terms": [], "name": "P8_CR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043917": {"description": "Domain of unknown function DUF5753", "go_ids": [], "go_terms": [], "name": "DUF5753", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043918": {"description": "Protein of unknown function DUF5760", "go_ids": [], "go_terms": [], "name": "DUF5760", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043919": {"description": "Domain of unknown function DUF5758", "go_ids": [], "go_terms": [], "name": "DUF5758", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043920": {"description": "Protein of unknown function DUF5757", "go_ids": [], "go_terms": [], "name": "DUF5757", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043921": {"description": "Protein of unknown function DUF5772", "go_ids": [], "go_terms": [], "name": "DUF5772", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043922": {"description": "Protein of unknown function DUF5773", "go_ids": [], "go_terms": [], "name": "DUF5773", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043923": {"description": "Protein of unknown function DUF5774", "go_ids": [], "go_terms": [], "name": "DUF5774", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043924": {"description": "Protein of unknown function DUF5775", "go_ids": [], "go_terms": [], "name": "DUF5775", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043926": {"description": "ABC transporter family G domain", "go_ids": ["GO:0140359"], "go_terms": ["GO:0140359:ABC-type transporter activity:F"], "name": "ABCG_dom", "pathway_ids": ["R-MMU-9753281", "R-RNO-189451", "R-SSC-189483", "R-HSA-9725554", "R-RNO-9753281", "R-DDI-1660661", "R-MMU-1369062", "R-HSA-5679096", "R-SSC-1660661", "R-HSA-1369062", "R-DME-1660661", "R-SSC-189451", "R-DDI-189451", "R-HSA-189483", "R-MMU-917937", "R-MMU-189483", "R-RNO-9793528", "R-SSC-917937", "R-DME-9753281", "R-DME-917937", "R-RNO-189483", "R-HSA-9029569", "R-MMU-8964058", "R-DDI-1369062", "R-DME-189451", "R-SSC-9793528", "R-MMU-189451", "R-HSA-8964058", "R-DDI-917937", "R-RNO-917937", "R-HSA-5679090", "R-DME-1369062", "R-DDI-9793528", "R-DDI-8964058", "R-HSA-9753281", "R-HSA-2161517", "R-HSA-1660661", "R-MMU-9793528", "R-HSA-917937", "R-SSC-9753281", "R-HSA-9818032", "R-RNO-1660661", "R-RNO-1369062", "R-DME-189483", "R-DME-9793528", "R-DDI-189483", "R-HSA-9793528", "R-DDI-9753281", "R-HSA-189451", "R-MMU-1660661"], "pathways": ["R-MMU-9753281:r:Paracetamol ADME", "R-RNO-189451:r:Heme biosynthesis", "R-SSC-189483:r:Heme degradation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-RNO-9753281:r:Paracetamol ADME", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-5679096:r:Defective ABCG5 causes sitosterolemia", "R-SSC-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-SSC-189451:r:Heme biosynthesis", "R-DDI-189451:r:Heme biosynthesis", "R-HSA-189483:r:Heme degradation", "R-MMU-917937:r:Iron uptake and transport", "R-MMU-189483:r:Heme degradation", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-SSC-917937:r:Iron uptake and transport", "R-DME-9753281:r:Paracetamol ADME", "R-DME-917937:r:Iron uptake and transport", "R-RNO-189483:r:Heme degradation", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-8964058:r:HDL remodeling", "R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-DME-189451:r:Heme biosynthesis", "R-SSC-9793528:r:Ciprofloxacin ADME", "R-MMU-189451:r:Heme biosynthesis", "R-HSA-8964058:r:HDL remodeling", "R-DDI-917937:r:Iron uptake and transport", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-5679090:r:Defective ABCG8 causes GBD4 and sitosterolemia", "R-DME-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-9793528:r:Ciprofloxacin ADME", "R-DDI-8964058:r:HDL remodeling", "R-HSA-9753281:r:Paracetamol ADME", "R-HSA-2161517:r:Abacavir transmembrane transport", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-HSA-917937:r:Iron uptake and transport", "R-SSC-9753281:r:Paracetamol ADME", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-DME-189483:r:Heme degradation", "R-DME-9793528:r:Ciprofloxacin ADME", "R-DDI-189483:r:Heme degradation", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-DDI-9753281:r:Paracetamol ADME", "R-HSA-189451:r:Heme biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Domain"}, "IPR043927": {"description": "Protein of unknown function DUF5778", "go_ids": [], "go_terms": [], "name": "DUF5778", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043928": {"description": "DVNP family", "go_ids": ["GO:0003677", "GO:0051276"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0051276:chromosome organization:P"], "name": "DNVP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043929": {"description": "Protein of unknown function DUF5755", "go_ids": [], "go_terms": [], "name": "DUF5755", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043930": {"description": "Protein of unknown function DUF5754", "go_ids": [], "go_terms": [], "name": "DUF5754", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043931": {"description": "Protein of unknown function DUF5779", "go_ids": [], "go_terms": [], "name": "DUF5779", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043934": {"description": "SidE, DUB domain", "go_ids": ["GO:0016579"], "go_terms": ["GO:0016579:protein deubiquitination:P"], "name": "SidE_DUB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043935": {"description": "SidE, mono-ADP-ribosyltransferase domain", "go_ids": ["GO:0106274"], "go_terms": ["GO:0106274:NAD+-protein-arginine ADP-ribosyltransferase activity:F"], "name": "SidE_mART", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043936": {"description": "HOOK, N-terminal", "go_ids": ["GO:0030705"], "go_terms": ["GO:0030705:cytoskeleton-dependent intracellular transport:P"], "name": "HOOK_N", "pathway_ids": ["R-MMU-9696264", "R-HSA-5368598", "R-MMU-9696273", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-5368598:r:Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR043937": {"description": "Golgin subfamily A , C-terminal binding motif", "go_ids": ["GO:0005794", "GO:0005801", "GO:0005515"], "go_terms": ["GO:0005794:Golgi apparatus:C", "GO:0005801:cis-Golgi network:C", "GO:0005515:protein binding:F"], "name": "GOLGA_C", "pathway_ids": ["R-HSA-204005", "R-HSA-9013405", "R-MMU-204005", "R-DRE-9013148", "R-RNO-162658", "R-RNO-6807878", "R-MMU-162658", "R-DRE-6807878", "R-HSA-9013148", "R-HSA-6807878", "R-HSA-8862803", "R-MMU-6807878", "R-RNO-204005", "R-DRE-162658", "R-HSA-162658"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-DRE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization"], "type": "Conserved_site"}, "IPR043938": {"description": "Ligase-CoA domain", "go_ids": ["GO:0043758"], "go_terms": ["GO:0043758:acetate-CoA ligase (ADP-forming) activity:F"], "name": "Ligase_CoA_dom", "pathway_ids": ["PWY-5483", "PWY-5535", "PWY-8305"], "pathways": ["PWY-5483:t:pyruvate fermentation to acetate III", "PWY-5535:t:acetate and ATP formation from acetyl-CoA II", "PWY-8305:t:methoxylated aromatic compound degradation II"], "type": "Domain"}, "IPR043939": {"description": "Domain of unknown function DUF5780", "go_ids": [], "go_terms": [], "name": "DUF5780", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043940": {"description": "Protein of unknown function DUF5781", "go_ids": [], "go_terms": [], "name": "DUF5781", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043941": {"description": "EMC6-arch", "go_ids": [], "go_terms": [], "name": "EMC6-arch", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043952": {"description": "Protein of unknown function DUF5783", "go_ids": [], "go_terms": [], "name": "DUF5783", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043953": {"description": "Protein of unknown function DUF5784", "go_ids": [], "go_terms": [], "name": "DUF5784", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043954": {"description": "Snu56-like U1 small nuclear ribonucleoprotein component", "go_ids": ["GO:0003729", "GO:0000398"], "go_terms": ["GO:0003729:mRNA binding:F", "GO:0000398:mRNA splicing, via spliceosome:P"], "name": "Snu56_snRNP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043955": {"description": "Domain of unknown function DUF5746", "go_ids": [], "go_terms": [], "name": "DUF5746", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043957": {"description": "Vanin, C-terminal", "go_ids": [], "go_terms": [], "name": "Vanin_C", "pathway_ids": ["R-CFA-199220", "R-HSA-6798695", "R-RNO-196780", "R-MMU-163125", "R-DME-196780", "R-CFA-163125", "R-HSA-196780", "R-HSA-3371598", "R-MMU-6798695", "R-CFA-6798695", "R-HSA-199220", "R-MMU-199220", "R-MMU-196780", "R-HSA-163125"], "pathways": ["R-CFA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-196780:r:Biotin transport and metabolism", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-DME-196780:r:Biotin transport and metabolism", "R-CFA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-196780:r:Biotin transport and metabolism", "R-HSA-3371598:r:Defective BTD causes biotidinase deficiency", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-6798695:r:Neutrophil degranulation", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Domain"}, "IPR043958": {"description": "Ta1207 family", "go_ids": [], "go_terms": [], "name": "Ta1207", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043959": {"description": "CRISPR system CMR subunit Cmr7 1", "go_ids": ["GO:0051607", "GO:0099048"], "go_terms": ["GO:0051607:defense response to virus:P", "GO:0099048:CRISPR-cas system:P"], "name": "Cmr7A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043960": {"description": "Protein of unknown function DUF5748", "go_ids": [], "go_terms": [], "name": "DUF5748", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043961": {"description": "Protein of unknown function DUF5749", "go_ids": [], "go_terms": [], "name": "DUF5749", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043962": {"description": "Protein of unknown function DUF5750", "go_ids": [], "go_terms": [], "name": "DUF5750", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043963": {"description": "Domain of unknown function DUF5751", "go_ids": [], "go_terms": [], "name": "DUF5751", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043964": {"description": "TraG, P-loop domain", "go_ids": [], "go_terms": [], "name": "P-loop_TraG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043965": {"description": "Nuclear cap-binding complex subunit CBP66, C-terminal domain", "go_ids": ["GO:0005846"], "go_terms": ["GO:0005846:nuclear cap binding complex:C"], "name": "CBP66_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043966": {"description": "Nuclear cap-binding complex subunit CBP110", "go_ids": ["GO:0005846"], "go_terms": ["GO:0005846:nuclear cap binding complex:C"], "name": "CBP110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043967": {"description": "Nuclear cap-binding complex subunit CBP30", "go_ids": ["GO:0005846"], "go_terms": ["GO:0005846:nuclear cap binding complex:C"], "name": "CBP30", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043968": {"description": "SGNH domain", "go_ids": [], "go_terms": [], "name": "SGNH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043969": {"description": "MAP3K, PH domain", "go_ids": ["GO:0000165"], "go_terms": ["GO:0000165:MAPK cascade:P"], "name": "MAP3K_PH", "pathway_ids": ["R-HSA-2559580", "R-CEL-2559580", "R-MMU-2559580"], "pathways": ["R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-2559580:r:Oxidative Stress Induced Senescence"], "type": "Domain"}, "IPR043970": {"description": "FUZ/MON1/HPS1, third Longin domain", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "FUZ/MON1/HPS1_longin_3", "pathway_ids": ["R-MMU-8876198", "R-HSA-5610787", "R-DME-450728", "R-MMU-5610787", "R-DME-8876198", "R-XTR-5610787", "R-GGA-8876198", "R-DME-5610787", "R-BTA-8876198", "R-RNO-5610787", "R-HSA-8876198", "R-SCE-8876198"], "pathways": ["R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-5610787:r:Hedgehog 'off' state", "R-GGA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-5610787:r:Hedgehog 'off' state", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5610787:r:Hedgehog 'off' state", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR043971": {"description": "FUZ/MON1/HPS1, second Longin domain", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "FUZ/MON1/HPS1_longin_2", "pathway_ids": ["R-MMU-8876198", "R-HSA-5610787", "R-DME-450728", "R-MMU-5610787", "R-DME-8876198", "R-XTR-5610787", "R-GGA-8876198", "R-DME-5610787", "R-BTA-8876198", "R-RNO-5610787", "R-HSA-8876198", "R-SCE-8876198"], "pathways": ["R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-5610787:r:Hedgehog 'off' state", "R-GGA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-5610787:r:Hedgehog 'off' state", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5610787:r:Hedgehog 'off' state", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR043972": {"description": "FUZ/MON1/HPS1, first Longin domain", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "FUZ/MON1/HPS1_longin_1", "pathway_ids": ["R-MMU-8876198", "R-HSA-5610787", "R-DME-450728", "R-MMU-5610787", "R-DME-8876198", "R-XTR-5610787", "R-GGA-8876198", "R-DME-5610787", "R-BTA-8876198", "R-RNO-5610787", "R-HSA-8876198", "R-SCE-8876198"], "pathways": ["R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-5610787:r:Hedgehog 'off' state", "R-GGA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-5610787:r:Hedgehog 'off' state", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5610787:r:Hedgehog 'off' state", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR043973": {"description": "CCN, TSP1 domain", "go_ids": ["GO:0007165"], "go_terms": ["GO:0007165:signal transduction:P"], "name": "TSP1_CCN", "pathway_ids": ["R-HSA-2032785", "R-RNO-381426", "R-RNO-8957275", "R-MMU-381426", "R-HSA-8951671", "R-GGA-8957275", "R-HSA-8957275", "R-GGA-381426", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR043976": {"description": "Golgin subfamily A, conserved domain", "go_ids": [], "go_terms": [], "name": "GOLGA_cons_dom", "pathway_ids": ["R-HSA-204005", "R-HSA-9013405", "R-MMU-204005", "R-DRE-9013148", "R-RNO-162658", "R-RNO-6807878", "R-MMU-162658", "R-DRE-6807878", "R-HSA-9013148", "R-HSA-6807878", "R-HSA-8862803", "R-MMU-6807878", "R-RNO-204005", "R-DRE-162658", "R-HSA-162658"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-DRE-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization"], "type": "Domain"}, "IPR043977": {"description": "Protein of unknown function DUF5759", "go_ids": [], "go_terms": [], "name": "DUF5759", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043979": {"description": "Domain of unknown function DUF5741", "go_ids": [], "go_terms": [], "name": "DUF5741", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043984": {"description": "Domain of unknown function DUF5742", "go_ids": [], "go_terms": [], "name": "DUF5742", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043987": {"description": "CCZ1/INTU/HSP4, first Longin domain", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "CCZ1/INTU/HSP4_longin_1", "pathway_ids": ["R-DRE-5610787", "R-MMU-8876198", "R-DDI-8876198", "R-HSA-5610787", "R-MMU-5610787", "R-DME-450728", "R-DME-8876198", "R-XTR-5610787", "R-BTA-8876198", "R-DME-5610787", "R-RNO-5610787", "R-BTA-5610787", "R-HSA-8876198", "R-SCE-8876198", "R-DRE-8876198"], "pathways": ["R-DRE-5610787:r:Hedgehog 'off' state", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-450728:r:Inhibition of actin polymerization", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-5610787:r:Hedgehog 'off' state", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-5610787:r:Hedgehog 'off' state", "R-RNO-5610787:r:Hedgehog 'off' state", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR043988": {"description": "CCZ1/INTU, second Longin domain", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "CCZ1/INTU_longin_2", "pathway_ids": ["R-DRE-5610787", "R-MMU-8876198", "R-HSA-5610787", "R-MMU-5610787", "R-DME-8876198", "R-XTR-5610787", "R-BTA-8876198", "R-DME-5610787", "R-RNO-5610787", "R-BTA-5610787", "R-HSA-8876198", "R-DME-450728", "R-DRE-8876198"], "pathways": ["R-DRE-5610787:r:Hedgehog 'off' state", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-5610787:r:Hedgehog 'off' state", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-5610787:r:Hedgehog 'off' state", "R-RNO-5610787:r:Hedgehog 'off' state", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-450728:r:Inhibition of actin polymerization", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR043989": {"description": "CCZ1/INTU/HPS4, third Longin domain", "go_ids": ["GO:0016192"], "go_terms": ["GO:0016192:vesicle-mediated transport:P"], "name": "CCZ1/INTU/HSP4_longin_3", "pathway_ids": ["R-DRE-8876198", "R-DRE-5610787", "R-MMU-8876198", "R-DDI-8876198", "R-HSA-5610787", "R-MMU-5610787", "R-DME-8876198", "R-XTR-5610787", "R-BTA-8876198", "R-DME-5610787", "R-RNO-5610787", "R-BTA-5610787", "R-HSA-8876198", "R-DME-450728"], "pathways": ["R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-5610787:r:Hedgehog 'off' state", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-XTR-5610787:r:Hedgehog 'off' state", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-5610787:r:Hedgehog 'off' state", "R-RNO-5610787:r:Hedgehog 'off' state", "R-BTA-5610787:r:Hedgehog 'off' state", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-450728:r:Inhibition of actin polymerization"], "type": "Domain"}, "IPR043990": {"description": "Autochaperone domain type 1", "go_ids": [], "go_terms": [], "name": "AC_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043991": {"description": "Recombination directionality factor-like", "go_ids": [], "go_terms": [], "name": "Gp3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043992": {"description": "Transglycosylase SLT domain 3", "go_ids": [], "go_terms": [], "name": "SLT_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043993": {"description": "Type IV secretion system pilin", "go_ids": [], "go_terms": [], "name": "T4SS_pilin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR043994": {"description": "Bacterial toxin, RNase RnlA/LsoA, DBD domain", "go_ids": ["GO:0004521"], "go_terms": ["GO:0004521:RNA endonuclease activity:F"], "name": "RnlA/LsoA-toxin_DBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR043998": {"description": "Putative phage metallopeptidase", "go_ids": [], "go_terms": [], "name": "Put_Metallopep", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044000": {"description": "Phage tail tube protein-like", "go_ids": [], "go_terms": [], "name": "Phage_tube_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044004": {"description": "Spondin-like TSP1 domain", "go_ids": [], "go_terms": [], "name": "TSP1_spondin_dom", "pathway_ids": ["R-RNO-5173214", "R-XTR-4641263", "R-DRE-5173214", "R-MMU-4641263", "R-HSA-5173214", "R-HSA-8939256", "R-MMU-5173214", "R-HSA-5083635", "R-DRE-4641263", "R-HSA-4641263", "R-BTA-5173214", "R-BTA-4641263"], "pathways": ["R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-DRE-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-DRE-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-BTA-4641263:r:Regulation of FZD by ubiquitination"], "type": "Domain"}, "IPR044005": {"description": "Double zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "DZR_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044015": {"description": "Fructose-1-6-bisphosphatase class 1, C-terminal", "go_ids": [], "go_terms": [], "name": "FBPase_C_dom", "pathway_ids": ["PWY-5484", "R-HSA-70263", "R-BTA-70263", "R-SSC-70263", "R-SPO-70263", "R-SCE-70263", "R-MMU-70263", "R-DDI-70263", "R-RNO-70263"], "pathways": ["PWY-5484:t:glycolysis II (from fructose 6-phosphate)", "R-HSA-70263:r:Gluconeogenesis", "R-BTA-70263:r:Gluconeogenesis", "R-SSC-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-MMU-70263:r:Gluconeogenesis", "R-DDI-70263:r:Gluconeogenesis", "R-RNO-70263:r:Gluconeogenesis"], "type": "Domain"}, "IPR044016": {"description": "Bacterial Ig-like domain 13", "go_ids": [], "go_terms": [], "name": "Big_13", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044019": {"description": "Cyanophycin synthase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Cyanophycin_syn_N", "pathway_ids": ["PWY-7052"], "pathways": ["PWY-7052:t:cyanophycin metabolism"], "type": "Domain"}, "IPR044020": {"description": "Protein of unknown function DUF5676", "go_ids": [], "go_terms": [], "name": "DUF5676", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044021": {"description": "Glycosyl-4,4'-diaponeurosporenoate acyltransferase", "go_ids": ["GO:0016746"], "go_terms": ["GO:0016746:acyltransferase activity:F"], "name": "CrtO", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR044023": {"description": "Ig-like domain CHU_C associated", "go_ids": [], "go_terms": [], "name": "Ig_7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044024": {"description": "Atypical Rib domain", "go_ids": [], "go_terms": [], "name": "aRib", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044031": {"description": "TssC1, N-terminal", "go_ids": [], "go_terms": [], "name": "TssC1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044032": {"description": "TssC1, C-terminal", "go_ids": [], "go_terms": [], "name": "TssC1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044033": {"description": "GpV-like, apex motif", "go_ids": [], "go_terms": [], "name": "GpV-like_apex", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR044034": {"description": "Nascent polypeptide-associated complex subunit alpha-like, UBA domain", "go_ids": [], "go_terms": [], "name": "NAC-like_UBA", "pathway_ids": ["R-HSA-9918487"], "pathways": ["R-HSA-9918487:r:Dengue Virus Genome Translation and Replication"], "type": "Domain"}, "IPR044035": {"description": "Domain of unknown function DUF5698", "go_ids": [], "go_terms": [], "name": "DUF5698", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044036": {"description": "Protein of unknown function DUF5752", "go_ids": [], "go_terms": [], "name": "DUF5752", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044037": {"description": "FANCL, UBC-like domain 3", "go_ids": [], "go_terms": [], "name": "FANCL_d3", "pathway_ids": ["PWY-7511", "R-MMU-9833482", "R-HSA-9833482", "R-HSA-6783310", "R-MMU-6783310"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR044038": {"description": "dATP/dGTP diphosphohydrolase, N-terminal", "go_ids": [], "go_terms": [], "name": "dATP/dGTP_diPOhydrolase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044039": {"description": "Domain of unknown function DUF5745", "go_ids": [], "go_terms": [], "name": "DUF5745", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044040": {"description": "Domain of unknown function DUF5744", "go_ids": [], "go_terms": [], "name": "DUF5744", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044041": {"description": "Domain of unknown function DUF5743", "go_ids": [], "go_terms": [], "name": "DUF5743", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044043": {"description": "Vanillate O-demethylase oxygenase-like, C-terminal catalytic domain", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "VanA_C_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044044": {"description": "Domain of unknown function DUF5679", "go_ids": [], "go_terms": [], "name": "DUF5679", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044046": {"description": "E3 ubiquitin-protein ligase UBR-like, C-terminal", "go_ids": [], "go_terms": [], "name": "E3_ligase_UBR-like_C", "pathway_ids": ["PWY-7511", "R-SPO-983168", "R-DME-983168", "R-SCE-983168", "R-HSA-983168", "R-CEL-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR044048": {"description": "Bacterial Ig-like domain 12", "go_ids": [], "go_terms": [], "name": "Big_12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044049": {"description": "EccD-like transmembrane domain", "go_ids": [], "go_terms": [], "name": "EccD_transm", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044050": {"description": "Protein of unknown function DUF5837", "go_ids": [], "go_terms": [], "name": "DUF5837", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044051": {"description": "Prophage endopeptidase tail, N-terminal", "go_ids": [], "go_terms": [], "name": "Prophage_tail_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044053": {"description": "Hydroxylase/desaturase AsaB-like", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "AsaB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044054": {"description": "Rv0078B-like antitoxin", "go_ids": [], "go_terms": [], "name": "Rv0078B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044055": {"description": "Long Rib domain", "go_ids": [], "go_terms": [], "name": "RibLong", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044056": {"description": "Internalin I, Ig-like domain", "go_ids": [], "go_terms": [], "name": "InlI_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044057": {"description": "SnTox1, chitin binding-like domain", "go_ids": [], "go_terms": [], "name": "SnTox1_CBL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044058": {"description": "Uncharacterised lipoprotein", "go_ids": [], "go_terms": [], "name": "Lipoprotein_23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044059": {"description": "Cns1/TTC4, wheel domain", "go_ids": ["GO:0051879"], "go_terms": ["GO:0051879:Hsp90 protein binding:F"], "name": "Csn1/TTC4_wheel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044060": {"description": "Bacterial repeat domain", "go_ids": [], "go_terms": [], "name": "Bacterial_rp_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044076": {"description": "Large ribosomal subunit protein P2, eukaryota", "go_ids": ["GO:0022625", "GO:0003735", "GO:0002182"], "go_terms": ["GO:0022625:cytosolic large ribosomal subunit:C", "GO:0003735:structural constituent of ribosome:F", "GO:0002182:cytoplasmic translational elongation:P"], "name": "Ribosomal_P2_euk", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-PFA-72689", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-PFA-9954709", "R-SCE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-PFA-9954716", "R-CEL-9954716", "R-CEL-9954714", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-MMU-6791226", "R-HSA-9633012", "R-RNO-156827", "R-BTA-156827", "R-SPO-72706", "R-MMU-9954714", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-PFA-1799339", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-PFA-975956", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-PFA-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-PFA-72706", "R-SPO-1799339", "R-SCE-1799339", "R-DME-1799339", "R-DDI-9954709", "R-DDI-9954716", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-PFA-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-PFA-9954714"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-PFA-72689:r:Formation of a pool of free 40S subunits", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-PFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 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dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-PFA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-PFA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-PFA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-PFA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-PFA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-PFA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "type": "Family"}, "IPR044081": {"description": "Domain of unknown function DUF5776", "go_ids": [], "go_terms": [], "name": "DUF5776", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044122": {"description": "UPF0261, N-terminal domain", "go_ids": [], "go_terms": [], "name": "UPF0261_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044132": {"description": "Glutamine-binding periplasmic protein GlnH, type 2 periplasmic binding protein fold", "go_ids": [], "go_terms": [], "name": "PBP2_GlnH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044144": {"description": "UxaA/GarD, SAF domain", "go_ids": [], "go_terms": [], "name": "SAF_UxaA/GarD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044149": {"description": "Nitrilase/Cyanide hydratase", "go_ids": ["GO:0003824"], "go_terms": ["GO:0003824:catalytic activity:F"], "name": "Nitrilases_CHs", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044152": {"description": "NADPH dehydrogenase YqjM-like", "go_ids": ["GO:0010181", "GO:0050661", "GO:0003959"], "go_terms": ["GO:0010181:FMN binding:F", "GO:0050661:NADP binding:F", "GO:0003959:NADPH dehydrogenase activity:F"], "name": "YqjM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044156": {"description": "Galectin-like", "go_ids": [], "go_terms": [], "name": "Galectin-like", "pathway_ids": ["R-BTA-8957275", "R-RNO-381426", "R-HSA-6798695", "R-HSA-8941333", "R-HSA-879415", "R-HSA-9725554", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-451927", "R-CEL-6798695", "R-MMU-6798695", "R-HSA-8957275", "R-CFA-6798695", "R-HSA-8939246", "R-MMU-8957275", "R-HSA-381426", "R-RNO-6798695"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8941333:r:RUNX2 regulates genes involved in differentiation of myeloid cells", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-451927:r:Interleukin-2 family signaling", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-CFA-6798695:r:Neutrophil degranulation", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR044159": {"description": "IQ domain-containing protein IQM", "go_ids": [], "go_terms": [], "name": "IQM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044160": {"description": "Protein TRIGALACTOSYLDIACYLGLYCEROL 4-like", "go_ids": ["GO:0070300", "GO:1990052", "GO:0034196"], "go_terms": ["GO:0070300:phosphatidic acid binding:F", "GO:1990052:ER to chloroplast lipid transport:P", "GO:0034196:acylglycerol transport:P"], "name": "TGD4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044161": {"description": "Sucrose-phosphate synthase", "go_ids": [], "go_terms": [], "name": "SPS", "pathway_ids": ["PWY-7238", "PWY-7347"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-7347:t:sucrose biosynthesis III"], "type": "Family"}, "IPR044162": {"description": "Universal stress protein PHOS32/34", "go_ids": [], "go_terms": [], "name": "PHOS32/34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044163": {"description": "Sanguinarine reductase SARED1-like", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "SARED1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044164": {"description": "Chalcone--flavonone isomerase", "go_ids": ["GO:0045430", "GO:0009813"], "go_terms": ["GO:0045430:chalcone isomerase activity:F", "GO:0009813:flavonoid biosynthetic process:P"], "name": "CFI", "pathway_ids": ["PWY-7397", "PWY-7897", "PWY-5059", "PWY-2002", "PWY-6787", "PWY-6325"], "pathways": ["PWY-7397:t:naringenin biosynthesis (engineered)", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5059:t:pinobanksin biosynthesis", "PWY-2002:t:isoflavonoid biosynthesis I", "PWY-6787:t:flavonoid biosynthesis (in equisetum)", "PWY-6325:t:echinatin biosynthesis"], "type": "Family"}, "IPR044165": {"description": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4, plant", "go_ids": [], "go_terms": [], "name": "OST4_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044166": {"description": "Ferredoxin-thioredoxin reductase, variable chain", "go_ids": ["GO:0015979"], "go_terms": ["GO:0015979:photosynthesis:P"], "name": "FTRV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044167": {"description": "Bowman-Birk type wound-induced proteinase inhibitor WIP1", "go_ids": ["GO:0004867"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F"], "name": "WIP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044168": {"description": "bZIP transcription factor RISBZ3/4/5", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "RISBZ3/4/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044169": {"description": "Protein PYRICULARIA ORYZAE RESISTANCE 21", "go_ids": ["GO:1900150"], "go_terms": ["GO:1900150:regulation of defense response to fungus:P"], "name": "PI21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044170": {"description": "Protein RICE SALT SENSITIVE 3-like", "go_ids": [], "go_terms": [], "name": "RSS3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044171": {"description": "Protein LAX PANICLE 2-like", "go_ids": ["GO:0007275"], "go_terms": ["GO:0007275:multicellular organism development:P"], "name": "LAX2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044172": {"description": "Transcription factor ILI2-like", "go_ids": [], "go_terms": [], "name": "ILI2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044173": {"description": "Casparian strip membrane protein/CASP-like protein", "go_ids": [], "go_terms": [], "name": "CASPL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044174": {"description": "Glycosyltransferase BC10-like", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "BC10-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044175": {"description": "Pentatricopeptide repeat-containing protein At5g66631-like", "go_ids": [], "go_terms": [], "name": "At5g66631-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044176": {"description": "Thioredoxin-like 4, chloroplastic", "go_ids": [], "go_terms": [], "name": "TRL4_chloroplastic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044177": {"description": "Reticulon-like protein B22/B23", "go_ids": [], "go_terms": [], "name": "RTNLB22/23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044178": {"description": "Peptidyl-prolyl cis-trans isomerase CYP28-like", "go_ids": [], "go_terms": [], "name": "CYP28-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044179": {"description": "Pentatricopeptide repeat-containing protein PPR5-like", "go_ids": ["GO:0003729"], "go_terms": ["GO:0003729:mRNA binding:F"], "name": "PPR5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044180": {"description": "Peptidyl-prolyl cis-trans isomerase FKBP18-like", "go_ids": [], "go_terms": [], "name": "FKBP18-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044181": {"description": "FCS-Like Zinc finger 17/18", "go_ids": [], "go_terms": [], "name": "FLZ17/18", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044182": {"description": "Thioredoxin-like protein CITRX, chloroplastic", "go_ids": ["GO:0045454", "GO:0015035"], "go_terms": ["GO:0045454:cell redox homeostasis:P", "GO:0015035:protein-disulfide reductase activity:F"], "name": "CITRX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044183": {"description": "Photosynthetic NDH subunit of lumenal location 4/FKBP13-like", "go_ids": ["GO:0009507"], "go_terms": ["GO:0009507:chloroplast:C"], "name": "PNSL4/FKBP13-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044184": {"description": "F-box protein SNE/GID2", "go_ids": ["GO:0009937", "GO:0019005"], "go_terms": ["GO:0009937:regulation of gibberellic acid mediated signaling pathway:P", "GO:0019005:SCF ubiquitin ligase complex:C"], "name": "SNE/GID2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044185": {"description": "Peptidyl-prolyl cis-trans isomerase CYP26-2-like", "go_ids": [], "go_terms": [], "name": "CYP26-2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044186": {"description": "WUSCHEL-related homeobox 4", "go_ids": ["GO:0003700", "GO:0010087", "GO:0051301", "GO:0010067"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0010087:phloem or xylem histogenesis:P", "GO:0051301:cell division:P", "GO:0010067:procambium histogenesis:P"], "name": "WOX4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044187": {"description": "Universal stress protein A-like protein, plant", "go_ids": [], "go_terms": [], "name": "At3g01520-like_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044189": {"description": "Exportin 4/7-like", "go_ids": ["GO:0005049", "GO:0051169"], "go_terms": ["GO:0005049:nuclear export signal receptor activity:F", "GO:0051169:nuclear transport:P"], "name": "XPO4/7-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044190": {"description": "Protein THYLAKOID ASSEMBLY 8-like", "go_ids": ["GO:0000373", "GO:0009658", "GO:0003723"], "go_terms": ["GO:0000373:Group II intron splicing:P", "GO:0009658:chloroplast organization:P", "GO:0003723:RNA binding:F"], "name": "THA8-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044191": {"description": "Chalcone--flavonone isomerase 3-like", "go_ids": [], "go_terms": [], "name": "CHI3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044192": {"description": "Thioredoxin-like protein CDSP32", "go_ids": ["GO:0016671"], "go_terms": ["GO:0016671:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor:F"], "name": "CDSP32", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044193": {"description": "Thioredoxin-like 3-3", "go_ids": [], "go_terms": [], "name": "TRL33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044194": {"description": "Protein BLISTER", "go_ids": ["GO:0040008"], "go_terms": ["GO:0040008:regulation of growth:P"], "name": "BLISTER", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044196": {"description": "Uncharacterized protein At5g19025-like", "go_ids": [], "go_terms": [], "name": "At5g19025-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044197": {"description": "Peptidyl-prolyl cis-trans isomerase FKBP17-1-like", "go_ids": [], "go_terms": [], "name": "FKBP17-1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044198": {"description": "Protein DEK", "go_ids": ["GO:0003677", "GO:0006325"], "go_terms": ["GO:0003677:DNA binding:F", "GO:0006325:chromatin organization:P"], "name": "DEK", "pathway_ids": ["R-HSA-9616222", "R-RNO-5250924", "R-MMU-5250924", "R-MMU-8864260", "R-HSA-8864260", "R-RNO-8864260", "R-HSA-5250924"], "pathways": ["R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-HSA-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-RNO-8864260:r:Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression"], "type": "Family"}, "IPR044199": {"description": "NAD(P)H-quinone oxidoreductase subunit U, chloroplastic", "go_ids": ["GO:0010598", "GO:0009535"], "go_terms": ["GO:0010598:NAD(P)H dehydrogenase complex (plastoquinone):C", "GO:0009535:chloroplast thylakoid membrane:C"], "name": "NdhU_chloroplastic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044200": {"description": "Uncharacterized protein At5g03900-like", "go_ids": [], "go_terms": [], "name": "At5g03900-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044201": {"description": "Divinyl reductase-like", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "DVR-like", "pathway_ids": ["PWY-5064", "PWY-5086", "PWY-7758", "PWY-7759", "PWY-5526", "PWY-7760"], "pathways": ["PWY-5064:t:chlorophyll a biosynthesis II", "PWY-5086:t:chlorophyll a biosynthesis I", "PWY-7758:t:bacteriochlorophyll d biosynthesis", "PWY-7759:t:bacteriochlorophyll c biosynthesis", "PWY-5526:t:bacteriochlorophyll a biosynthesis", "PWY-7760:t:bacteriochlorophyll e biosynthesis"], "type": "Family"}, "IPR044202": {"description": "LETM1/MDM38-like", "go_ids": ["GO:0005743"], "go_terms": ["GO:0005743:mitochondrial inner membrane:C"], "name": "LETM1/MDM38-like", "pathway_ids": ["R-MMU-9013408", "R-RNO-9013408", "R-HSA-9013408", "R-HSA-8949215", "R-XTR-9013408", "R-HSA-9865881", "R-DRE-9013408"], "pathways": ["R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-XTR-9013408:r:RHOG GTPase cycle", "R-HSA-9865881:r:Complex III assembly", "R-DRE-9013408:r:RHOG GTPase cycle"], "type": "Family"}, "IPR044203": {"description": "Group 2 truncated hemoglobin GlbO/Two-on-two hemoglobin-3-like", "go_ids": ["GO:0005344", "GO:0015671"], "go_terms": ["GO:0005344:oxygen carrier activity:F", "GO:0015671:oxygen transport:P"], "name": "GlbO/GLB3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044204": {"description": "Protein IWS1 homolog 1/2", "go_ids": ["GO:0032784", "GO:0009742"], "go_terms": ["GO:0032784:regulation of DNA-templated transcription elongation:P", "GO:0009742:brassinosteroid mediated signaling pathway:P"], "name": "IWS1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044205": {"description": "Calcium-binding protein KIC/PBP1/KRP1", "go_ids": ["GO:0005509"], "go_terms": ["GO:0005509:calcium ion binding:F"], "name": "KIC/PBP1/KRP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044206": {"description": "EG45-like domain containing protein, plant", "go_ids": ["GO:0048046", "GO:0009627"], "go_terms": ["GO:0048046:apoplast:C", "GO:0009627:systemic acquired resistance:P"], "name": "EGC1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044207": {"description": "F-box protein At5g39250-like", "go_ids": [], "go_terms": [], "name": "At5g39250-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044208": {"description": "Peptidyl-prolyl cis-trans isomerase FKBP19-like", "go_ids": [], "go_terms": [], "name": "FKBP19-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044209": {"description": "Protein MODIFIER OF SNC1 11", "go_ids": ["GO:0016973"], "go_terms": ["GO:0016973:poly(A)+ mRNA export from nucleus:P"], "name": "MOS11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044210": {"description": "Transcription factor Tfc3-like", "go_ids": ["GO:0000127", "GO:0006384", "GO:0003677"], "go_terms": ["GO:0000127:transcription factor TFIIIC complex:C", "GO:0006384:transcription initiation at RNA polymerase III promoter:P", "GO:0003677:DNA binding:F"], "name": "Tfc3-like", "pathway_ids": ["R-SCE-76066", "R-RNO-76061", "R-HSA-76066", "R-SPO-76066", "R-HSA-76061", "R-MMU-76061", "R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-RNO-76066", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR044211": {"description": "Pheophytinase, chloroplastic", "go_ids": ["GO:0080124", "GO:0015996"], "go_terms": ["GO:0080124:pheophytinase activity:F", "GO:0015996:chlorophyll catabolic process:P"], "name": "PPH_chloroplastic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044212": {"description": "Protein-tyrosine-phosphatase IBR5-like", "go_ids": ["GO:0033549", "GO:0009734", "GO:0043407", "GO:0009738"], "go_terms": ["GO:0033549:MAP kinase phosphatase activity:F", "GO:0009734:auxin-activated signaling pathway:P", "GO:0043407:negative regulation of MAP kinase activity:P", "GO:0009738:abscisic acid-activated signaling pathway:P"], "name": "IBR5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044213": {"description": "Thylakoid lumenal 15kDa protein 1-like", "go_ids": [], "go_terms": [], "name": "At2g44920-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044214": {"description": "EDS1-like", "go_ids": ["GO:0006952"], "go_terms": ["GO:0006952:defense response:P"], "name": "EDS1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044215": {"description": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit H", "go_ids": ["GO:0000506", "GO:0006506"], "go_terms": ["GO:0000506:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex:C", "GO:0006506:GPI anchor biosynthetic process:P"], "name": "PIG-H", "pathway_ids": ["R-HSA-162710", "R-SPO-162710", "R-MMU-162710"], "pathways": ["R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-SPO-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-MMU-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Family"}, "IPR044216": {"description": "Protein WVD2-like 7", "go_ids": [], "go_terms": [], "name": "WDL7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044217": {"description": "ATP-dependent Clp protease ATP-binding subunit CLPT1/2", "go_ids": [], "go_terms": [], "name": "CLPT1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044218": {"description": "Protein SWEETIE", "go_ids": ["GO:0005975"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P"], "name": "SWEETIE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044219": {"description": "Alkaline ceramidase, plant", "go_ids": ["GO:0006914", "GO:0009651", "GO:0098542"], "go_terms": ["GO:0006914:autophagy:P", "GO:0009651:response to salt stress:P", "GO:0098542:defense response to other organism:P"], "name": "ACER_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044221": {"description": "Protein DYAD/AMEIOTIC 1", "go_ids": ["GO:0051321", "GO:0051177", "GO:0007131"], "go_terms": ["GO:0051321:meiotic cell cycle:P", "GO:0051177:meiotic sister chromatid cohesion:P", "GO:0007131:reciprocal meiotic recombination:P"], "name": "DYAD/AMEIOTIC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044222": {"description": "Aquaporin SIP1-1/2-like", "go_ids": ["GO:0015250"], "go_terms": ["GO:0015250:water channel activity:F"], "name": "SIP1-1/2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044224": {"description": "Glycosyltransferase-like KOBITO 1", "go_ids": ["GO:0030244", "GO:0009737"], "go_terms": ["GO:0030244:cellulose biosynthetic process:P", "GO:0009737:response to abscisic acid:P"], "name": "KOBITO1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044225": {"description": "Ent-kaurene oxidase, chloroplastic", "go_ids": ["GO:0020037", "GO:0005506", "GO:0010241", "GO:0009686", "GO:0052615"], "go_terms": ["GO:0020037:heme binding:F", "GO:0005506:iron ion binding:F", "GO:0010241:ent-kaurene oxidation to kaurenoic acid:P", "GO:0009686:gibberellin biosynthetic process:P", "GO:0052615:ent-kaurene oxidase activity:F"], "name": "KO_chloroplastic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044226": {"description": "Aquaporin SIP2-1-like", "go_ids": ["GO:0015267"], "go_terms": ["GO:0015267:channel activity:F"], "name": "SIP2-1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044227": {"description": "Protein TONSOKU", "go_ids": ["GO:0006325", "GO:0005634", "GO:0009933", "GO:0072423", "GO:0040029"], "go_terms": ["GO:0006325:chromatin organization:P", "GO:0005634:nucleus:C", "GO:0009933:meristem structural organization:P", "GO:0072423:response to DNA damage checkpoint signaling:P", "GO:0040029:epigenetic regulation of gene expression:P"], "name": "TONSOKU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044228": {"description": "Fatty-acid-binding protein 1", "go_ids": [], "go_terms": [], "name": "FAP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044229": {"description": "NO-associated protein 1", "go_ids": ["GO:0003924"], "go_terms": ["GO:0003924:GTPase activity:F"], "name": "NOA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044230": {"description": "General transcription factor 3C polypeptide 4", "go_ids": ["GO:0004402", "GO:0006384", "GO:0000127"], "go_terms": ["GO:0004402:histone acetyltransferase activity:F", "GO:0006384:transcription initiation at RNA polymerase III promoter:P", "GO:0000127:transcription factor TFIIIC complex:C"], "name": "GTF3C4", "pathway_ids": ["R-SPO-76061", "R-MMU-76066", "R-HSA-749476", "R-HSA-76061", "R-SPO-76066", "R-HSA-76066", "R-MMU-76061"], "pathways": ["R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Family"}, "IPR044231": {"description": "E3 ubiquitin-protein ligase SP1-like", "go_ids": ["GO:0016567", "GO:0004842"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0004842:ubiquitin-protein transferase activity:F"], "name": "SP1/SPL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044232": {"description": "Plant UBX domain-containing protein 1", "go_ids": ["GO:0032984", "GO:0051117"], "go_terms": ["GO:0032984:protein-containing complex disassembly:P", "GO:0051117:ATPase binding:F"], "name": "PUX1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044233": {"description": "Peptidyl-prolyl cis-trans isomerase CYP23-like", "go_ids": [], "go_terms": [], "name": "CYP23-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044234": {"description": "Transmembrane protein 230", "go_ids": [], "go_terms": [], "name": "TMEM230", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044235": {"description": "E3 ubiquitin-protein ligase 1/2", "go_ids": ["GO:1904294", "GO:0061630"], "go_terms": ["GO:1904294:positive regulation of ERAD pathway:P", "GO:0061630:ubiquitin protein ligase activity:F"], "name": "RNFT1/2", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR044236": {"description": "Glycerophosphodiester phosphodiesterase GDPD4", "go_ids": [], "go_terms": [], "name": "GDPD4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044237": {"description": "Histone-lysine N-methyltransferase ATXR2-like", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "ATXR2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044238": {"description": "Histone-lysine N-methyltransferase ASHR2-like", "go_ids": [], "go_terms": [], "name": "ASHR2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044239": {"description": "Peptidyl-prolyl cis-trans isomerase FKBP20-2-like", "go_ids": [], "go_terms": [], "name": "FKBP20-2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044240": {"description": "Rhodanese-like domain-containing protein STR4-like", "go_ids": [], "go_terms": [], "name": "STR4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044241": {"description": "Thiol:disulfide interchange protein TxlA/HCF164", "go_ids": [], "go_terms": [], "name": "TxlA/HCF164", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044242": {"description": "Protein LHCP TRANSLOCATION DEFECT-like", "go_ids": ["GO:0090391", "GO:0006886", "GO:0009570"], "go_terms": ["GO:0090391:granum assembly:P", "GO:0006886:intracellular protein transport:P", "GO:0009570:chloroplast stroma:C"], "name": "LTD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044243": {"description": "Protein FLUORESCENT IN BLUE LIGHT", "go_ids": ["GO:0015995", "GO:0033014"], "go_terms": ["GO:0015995:chlorophyll biosynthetic process:P", "GO:0033014:tetrapyrrole biosynthetic process:P"], "name": "FLU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044244": {"description": "Tetratricopeptide repeat protein TTC27/Emw1", "go_ids": [], "go_terms": [], "name": "TTC27/Emw1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044245": {"description": "SprT-like domain-containing protein Spartan", "go_ids": ["GO:0006974", "GO:0003697", "GO:0004222"], "go_terms": ["GO:0006974:DNA damage response:P", "GO:0003697:single-stranded DNA binding:F", "GO:0004222:metalloendopeptidase activity:F"], "name": "Spartan", "pathway_ids": ["PWY-8119", "R-DRE-110320", "R-CEL-110320", "R-RNO-110320", "R-HSA-110320", "R-BTA-110320", "R-XTR-110320", "R-MMU-110320"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-XTR-110320:r:Translesion Synthesis by POLH", "R-MMU-110320:r:Translesion Synthesis by POLH"], "type": "Family"}, "IPR044246": {"description": "Zinc finger protein 3-like", "go_ids": ["GO:0009788"], "go_terms": ["GO:0009788:negative regulation of abscisic acid-activated signaling pathway:P"], "name": "ZFP3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044247": {"description": "E3 ubiquitin-protein ligase SPL2-like", "go_ids": ["GO:0004842"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F"], "name": "SPL2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044248": {"description": "Diphthamide biosynthesis protein 3/4-like", "go_ids": ["GO:0046872", "GO:0017183"], "go_terms": ["GO:0046872:metal ion binding:F", "GO:0017183:protein histidyl modification to diphthamide:P"], "name": "DPH3/4-like", "pathway_ids": ["R-DME-5358493", "R-SPO-5358493", "R-BTA-5358493", "R-SCE-5358493", "R-MMU-5358493", "R-CEL-5358493", "R-HSA-5358493"], "pathways": ["R-DME-5358493:r:Synthesis of diphthamide-EEF2", "R-SPO-5358493:r:Synthesis of diphthamide-EEF2", "R-BTA-5358493:r:Synthesis of diphthamide-EEF2", "R-SCE-5358493:r:Synthesis of diphthamide-EEF2", "R-MMU-5358493:r:Synthesis of diphthamide-EEF2", "R-CEL-5358493:r:Synthesis of diphthamide-EEF2", "R-HSA-5358493:r:Synthesis of diphthamide-EEF2"], "type": "Family"}, "IPR044249": {"description": "Probable E3 ubiquitin-protein ligase XERICO-like", "go_ids": [], "go_terms": [], "name": "XERICO-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044250": {"description": "Isochorismate synthase MenF-like", "go_ids": ["GO:0008909"], "go_terms": ["GO:0008909:isochorismate synthase activity:F"], "name": "MenF-like", "pathway_ids": ["PWY-8321", "PWY-6406", "PWY-5837", "PWY-5901"], "pathways": ["PWY-8321:t:salicylate biosynthesis II", "PWY-6406:t:salicylate biosynthesis I", "PWY-5837:t:2-carboxy-1,4-naphthoquinol biosynthesis", "PWY-5901:t:2,3-dihydroxybenzoate biosynthesis"], "type": "Family"}, "IPR044251": {"description": "Chromo domain-containing protein LHP1", "go_ids": ["GO:0031507", "GO:0006325"], "go_terms": ["GO:0031507:heterochromatin formation:P", "GO:0006325:chromatin organization:P"], "name": "LHP1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044252": {"description": "Large ribosomal subunit protein P3", "go_ids": ["GO:0003735", "GO:0005840"], "go_terms": ["GO:0003735:structural constituent of ribosome:F", "GO:0005840:ribosome:C"], "name": "RPP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044253": {"description": "Thioredoxin-like 3-1/3-2", "go_ids": ["GO:0009570"], "go_terms": ["GO:0009570:chloroplast stroma:C"], "name": "WCRKC1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044254": {"description": "BRCT domain-containing protein At4g02110-like", "go_ids": [], "go_terms": [], "name": "At4g02110-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044255": {"description": "Protein Dr1 homolog", "go_ids": [], "go_terms": [], "name": "Dr1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044256": {"description": "High chlorophyll fluorescence 244-like", "go_ids": [], "go_terms": [], "name": "HCF244-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044257": {"description": "Protein TRM32-like", "go_ids": [], "go_terms": [], "name": "TRM32-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044258": {"description": "Heavy metal-associated isoprenylated plant protein 9-like", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "HIPP09-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044259": {"description": "Peptidyl-prolyl cis-trans isomerase CYP37-like", "go_ids": [], "go_terms": [], "name": "CYP37-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044260": {"description": "F-box protein SKIP8-like", "go_ids": [], "go_terms": [], "name": "SKIP8-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044264": {"description": "Protoporphyrinogen IX dehydrogenase [quinone] HemG", "go_ids": ["GO:0070819", "GO:0004729", "GO:0010181", "GO:0006783"], "go_terms": ["GO:0070819:protoporphyrinogen oxidase activity, quinone as acceptor:F", "GO:0004729:protoporphyrinogen oxidase activity, oxygen as acceptor:F", "GO:0010181:FMN binding:F", "GO:0006783:heme biosynthetic process:P"], "name": "HemG", "pathway_ids": ["PWY-5531"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)"], "type": "Family"}, "IPR044268": {"description": "Phosphatidylinositol phosphate synthase PgsA1", "go_ids": ["GO:0008654", "GO:0016780"], "go_terms": ["GO:0008654:phospholipid biosynthetic process:P", "GO:0016780:phosphotransferase activity, for other substituted phosphate groups:F"], "name": "PIP_synthase_PgsA1", "pathway_ids": ["PWY-6580", "PWY-6350", "PWY-7817", "PWY-7981", "PWY-7819", "PWY-6804", "PWY-7820", "PWY-8248", "PWY-7816", "PWY-7818", "PWY-7815"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-6350:t:archaetidylinositol biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-6804:t:diacylglycerol biosynthesis (PUFA enrichment in oilseed)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"], "type": "Family"}, "IPR044273": {"description": "Transcription factor PIF3-like", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "PIF3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044274": {"description": "E3 ubiquitin-protein ligase RFI2", "go_ids": ["GO:0004842"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F"], "name": "RFI2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044275": {"description": "Cyclin-dependent kinase inhibitor, plant", "go_ids": ["GO:0004861", "GO:0045736", "GO:0051726"], "go_terms": ["GO:0004861:cyclin-dependent protein serine/threonine kinase inhibitor activity:F", "GO:0045736:negative regulation of cyclin-dependent protein serine/threonine kinase activity:P", "GO:0051726:regulation of cell cycle:P"], "name": "KRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044276": {"description": "Coiled-coil SMC6 And NSE5 INteracting (CANIN) domain", "go_ids": [], "go_terms": [], "name": "CANIN_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044277": {"description": "GBF-interacting protein 1", "go_ids": [], "go_terms": [], "name": "GIP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044278": {"description": "Transcription factor BHLH95-like", "go_ids": ["GO:0003700", "GO:0009960", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0009960:endosperm development:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "BHLH95-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044279": {"description": "Sorting nexin 2A/B", "go_ids": [], "go_terms": [], "name": "SNX2A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044280": {"description": "Transcriptional activator Hac1/HY5", "go_ids": ["GO:0000981", "GO:0045944"], "go_terms": ["GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific:F", "GO:0045944:positive regulation of transcription by RNA polymerase II:P"], "name": "Hac1/HY5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044281": {"description": "U3 snoRNP protein/Ribosome production factor 1", "go_ids": ["GO:0006364", "GO:0042134"], "go_terms": ["GO:0006364:rRNA processing:P", "GO:0042134:rRNA primary transcript binding:F"], "name": "IMP4/RPF1", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR044282": {"description": "Armadillo repeat protein ABAP1/ARIA", "go_ids": [], "go_terms": [], "name": "ABAP1/ARIA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044283": {"description": "Transcription factor FAMA/SPEECHLESS/MUTE-like", "go_ids": ["GO:0003700", "GO:0010052"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0010052:guard cell differentiation:P"], "name": "FAMA/SPEECHLESS/MUTE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044284": {"description": "Regulatory protein NPR5/6", "go_ids": ["GO:0099402"], "go_terms": ["GO:0099402:plant organ development:P"], "name": "NPR5/6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044285": {"description": "Periodic tryptophan protein 1", "go_ids": ["GO:0006364"], "go_terms": ["GO:0006364:rRNA processing:P"], "name": "PWP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044286": {"description": "E3 ubiquitin-protein ligase SINA-like, plant", "go_ids": [], "go_terms": [], "name": "SINL_plant", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR044287": {"description": "Protein SUPPRESSOR OF GENE SILENCING 3", "go_ids": ["GO:0031047", "GO:0051607"], "go_terms": ["GO:0031047:regulatory ncRNA-mediated gene silencing:P", "GO:0051607:defense response to virus:P"], "name": "SGS3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044288": {"description": "ZNF598/HEL2", "go_ids": ["GO:0061630", "GO:0072344"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0072344:rescue of stalled cytosolic ribosome:P"], "name": "ZNF598/HEL2", "pathway_ids": ["PWY-7511", "R-MMU-9954716", "R-HSA-9954716", "R-DRE-9954716"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "type": "Family"}, "IPR044289": {"description": "RING-H2 finger protein ATL67-70", "go_ids": ["GO:0016567", "GO:0016740"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0016740:transferase activity:F"], "name": "ATL67-70", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR044290": {"description": "Arabinosyltransferase RRA1/2/3", "go_ids": ["GO:0080147", "GO:0016757"], "go_terms": ["GO:0080147:root hair cell development:P", "GO:0016757:glycosyltransferase activity:F"], "name": "RRA1/2/3", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis"], "type": "Family"}, "IPR044291": {"description": "Zinc finger protein GIS/GIS2/ZFP8", "go_ids": ["GO:0003700", "GO:0009739", "GO:0010090", "GO:0010026"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0009739:response to gibberellin:P", "GO:0010090:trichome morphogenesis:P", "GO:0010026:trichome differentiation:P"], "name": "GIS/GIS2/ZFP8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044292": {"description": "Regulatory protein NPR", "go_ids": ["GO:2000022", "GO:2000031", "GO:0009862"], "go_terms": ["GO:2000022:regulation of jasmonic acid mediated signaling pathway:P", "GO:2000031:regulation of salicylic acid mediated signaling pathway:P", "GO:0009862:systemic acquired resistance, salicylic acid mediated signaling pathway:P"], "name": "NPR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044293": {"description": "Transcription factor PRE", "go_ids": ["GO:0040008", "GO:0006355", "GO:0046983"], "go_terms": ["GO:0040008:regulation of growth:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0046983:protein dimerization activity:F"], "name": "PRE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044294": {"description": "Lipase-like", "go_ids": [], "go_terms": [], "name": "Lipase-like", "pathway_ids": ["R-HSA-9696273", "R-MMU-9696273"], "pathways": ["R-HSA-9696273:r:RND1 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle"], "type": "Family"}, "IPR044295": {"description": "Transcription factor BIM1/2/3", "go_ids": ["GO:0003700", "GO:0046983", "GO:0006351"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0046983:protein dimerization activity:F", "GO:0006351:DNA-templated transcription:P"], "name": "BIM1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044296": {"description": "Heavy metal-associated isoprenylated plant protein 46", "go_ids": [], "go_terms": [], "name": "HIPP46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044297": {"description": "Protein CELLULOSE SYNTHASE INTERACTIVE 1/2/3", "go_ids": ["GO:0008017", "GO:0010330", "GO:0051211", "GO:2001006"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0010330:cellulose synthase complex:C", "GO:0051211:anisotropic cell growth:P", "GO:2001006:regulation of cellulose biosynthetic process:P"], "name": "CSI1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044298": {"description": "Adenine/Thymine-DNA glycosylase", "go_ids": ["GO:0006284", "GO:0016798"], "go_terms": ["GO:0006284:base-excision repair:P", "GO:0016798:hydrolase activity, acting on glycosyl bonds:F"], "name": "MIG/MutY", "pathway_ids": ["R-HSA-110331", "R-HSA-110357", "R-HSA-9608287", "R-RNO-110331", "R-HSA-9608290", "R-HSA-110330", "R-RNO-110357", "R-SPO-110331", "R-MMU-110331", "R-MMU-110357"], "pathways": ["R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9608287:r:Defective MUTYH substrate binding", "R-RNO-110331:r:Cleavage of the damaged purine", "R-HSA-9608290:r:Defective MUTYH substrate processing", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-RNO-110357:r:Displacement of DNA glycosylase by APEX1", "R-SPO-110331:r:Cleavage of the damaged purine", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1"], "type": "Family"}, "IPR044299": {"description": "Zinc finger protein GIS3/ZFP5/ZFP6", "go_ids": ["GO:0010090"], "go_terms": ["GO:0010090:trichome morphogenesis:P"], "name": "GIS3/ZFP5/ZFP6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044300": {"description": "Protein SENSITIVE TO PROTON RHIZOTOXICITY 1/2", "go_ids": ["GO:0010044", "GO:0010447"], "go_terms": ["GO:0010044:response to aluminum ion:P", "GO:0010447:response to acidic pH:P"], "name": "STOP1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044301": {"description": "Pathogenesis-related protein-4", "go_ids": ["GO:0006952", "GO:0004540"], "go_terms": ["GO:0006952:defense response:P", "GO:0004540:RNA nuclease activity:F"], "name": "PR4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044302": {"description": "Costars family", "go_ids": [], "go_terms": [], "name": "Costars", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044303": {"description": "Zinc finger protein ZAT1/4/9", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "ZAT1/4/9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044304": {"description": "Iron-sulfur protein NUBPL-like", "go_ids": ["GO:0051536", "GO:0016226", "GO:0005524"], "go_terms": ["GO:0051536:iron-sulfur cluster binding:F", "GO:0016226:iron-sulfur cluster assembly:P", "GO:0005524:ATP binding:F"], "name": "NUBPL-like", "pathway_ids": ["R-DME-6799198", "R-MMU-6799198", "R-DDI-6799198", "R-HSA-6799198"], "pathways": ["R-DME-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR044310": {"description": "mRNA-capping enzyme P5, Cap-0 specific (nucleoside-2'-O-)-methyltransferase, phytoreovirus", "go_ids": [], "go_terms": [], "name": "P5_2OMTase_Phytoreov", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Domain"}, "IPR044312": {"description": "MERS-CoV ORF8b protein-like", "go_ids": [], "go_terms": [], "name": "merbe_CoV_ORF8b-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044320": {"description": "NSP11, N-terminal, arterivirus", "go_ids": [], "go_terms": [], "name": "NSP11_Av_N", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR044323": {"description": "Non-structural protein ORF5, MERS-CoV-like", "go_ids": [], "go_terms": [], "name": "MERS-CoV-like_ORF5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044326": {"description": "NS7b protein, bat coronavirus HKU9-like", "go_ids": [], "go_terms": [], "name": "NS7b_batCoV-HKU9", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044342": {"description": "Orf10 protein, SARS-CoV-2", "go_ids": [], "go_terms": [], "name": "Orf10_SARS-CoV-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044343": {"description": "Nonstructural protein 13, 1B domain, coronavirus", "go_ids": [], "go_terms": [], "name": "NSP13_1B_dom_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "PWY-7379", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-191859", "R-HSA-9705671", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7379:t:mRNA capping II", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR044381": {"description": "NSP3, DPUP domain, murine hepatitis virus-like", "go_ids": [], "go_terms": [], "name": "NSP3_DPUP_MHV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Domain"}, "IPR044398": {"description": "Globin-sensor domain", "go_ids": ["GO:0019825", "GO:0020037"], "go_terms": ["GO:0019825:oxygen binding:F", "GO:0020037:heme binding:F"], "name": "Globin-sensor_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044441": {"description": "Dicer, double-stranded RNA-binding domain", "go_ids": ["GO:0003723", "GO:0031054", "GO:0030422"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0031054:pre-miRNA processing:P", "GO:0030422:siRNA processing:P"], "name": "DICER_DSRM", "pathway_ids": ["R-CEL-426486", "R-MMU-426486", "R-HSA-426486", "R-DME-203927", "R-MMU-203927", "R-HSA-9824594", "R-HSA-203927", "R-XTR-426486", "R-CEL-203927", "R-HSA-9820841", "R-HSA-9708296", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR044444": {"description": "Large ribosomal subunit protein mL44, dsRNA binding domain, metazoa", "go_ids": ["GO:0003725"], "go_terms": ["GO:0003725:double-stranded RNA binding:F"], "name": "Ribosomal_mL44_DSRM_metazoa", "pathway_ids": ["R-CEL-9937383", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-CEL-5389840", "R-MMU-5419276", "R-CEL-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840"], "pathways": ["R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation"], "type": "Domain"}, "IPR044492": {"description": "P-type ATPase, haloacid dehalogenase domain", "go_ids": [], "go_terms": [], "name": "P_typ_ATPase_HD_dom", "pathway_ids": ["R-HSA-6798695", "R-GGA-936837", "R-SPO-6798695", "R-RNO-6803544", "R-HSA-6803544", "R-DRE-936837", "R-XTR-936837", "R-CEL-6798695", "R-SCE-6798695", "R-DME-418359", "R-DDI-5578775", "R-BTA-936837", "R-SSC-936837", "R-CFA-936837", "R-MMU-418359", "R-HSA-9662360", "R-BTA-5578775", "R-CFA-5578775", "R-HSA-5578775", "R-MMU-6803544", "R-MMU-936837", "R-CFA-418359", "R-SPO-5578775", "R-DDI-418359", "R-CEL-936837", "R-SCE-418359", "R-DDI-936837", "R-HSA-418359", "R-HSA-1912420", "R-CEL-418359", "R-HSA-3299685", "R-GGA-418359", "R-DME-936837", "R-GGA-5578775", "R-DME-5578775", "R-RNO-5578775", "R-HSA-9662361", "R-RNO-418359", "R-SPO-418359", "R-MMU-5578775", "R-SPO-936837", "R-HSA-936837", "R-HSA-9679191", "R-SSC-5578775", "R-RNO-936837", "R-SCE-936837", "R-SCE-5578775", "R-CEL-5578775", "R-MMU-6798695", "R-SSC-418359", "R-BTA-418359"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-GGA-936837:r:Ion transport by P-type ATPases", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-6803544:r:Ion influx/efflux at host-pathogen interface", "R-HSA-6803544:r:Ion influx/efflux at host-pathogen interface", "R-DRE-936837:r:Ion transport by P-type ATPases", "R-XTR-936837:r:Ion transport by P-type ATPases", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-DME-418359:r:Reduction of cytosolic Ca++ levels", "R-DDI-5578775:r:Ion homeostasis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-SSC-936837:r:Ion transport by P-type ATPases", "R-CFA-936837:r:Ion transport by P-type ATPases", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-BTA-5578775:r:Ion homeostasis", "R-CFA-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-6803544:r:Ion influx/efflux at host-pathogen interface", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CFA-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-5578775:r:Ion homeostasis", "R-DDI-418359:r:Reduction of cytosolic Ca++ levels", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-SCE-418359:r:Reduction of cytosolic Ca++ levels", "R-DDI-936837:r:Ion transport by P-type ATPases", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-CEL-418359:r:Reduction of cytosolic Ca++ levels", "R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-GGA-418359:r:Reduction of cytosolic Ca++ levels", "R-DME-936837:r:Ion transport by P-type ATPases", "R-GGA-5578775:r:Ion homeostasis", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-SPO-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-5578775:r:Ion homeostasis", "R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SSC-5578775:r:Ion homeostasis", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases", "R-SCE-5578775:r:Ion homeostasis", "R-CEL-5578775:r:Ion homeostasis", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-418359:r:Reduction of cytosolic Ca++ levels", "R-BTA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Domain"}, "IPR044493": {"description": "Polynucleotide kinase PNKP, C-terminal phosphatase domain", "go_ids": ["GO:0047846"], "go_terms": ["GO:0047846:deoxynucleotide 3'-phosphatase activity:F"], "name": "PNKP_C_HAD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044508": {"description": "F-box protein At5g50450/At1g67340-like", "go_ids": [], "go_terms": [], "name": "At5g50450/At1g67340-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044509": {"description": "CRIB domain-containing protein RIC2/4", "go_ids": [], "go_terms": [], "name": "RIC2/4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044511": {"description": "ProlycopenC2 and GRAM domain-containing protein At1g03370/At5g50170-like", "go_ids": [], "go_terms": [], "name": "At1g03370/At5g50170-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044513": {"description": "BTB/POZ and TAZ domain-containing protein 1/2/3/4/5", "go_ids": [], "go_terms": [], "name": "BT1/2/3/4/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044514": {"description": "Vernalization insensitive 3-like", "go_ids": ["GO:0010048", "GO:0040029"], "go_terms": ["GO:0010048:vernalization response:P", "GO:0040029:epigenetic regulation of gene expression:P"], "name": "VIN3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044515": {"description": "Ankyrin repeat and BTB/POZ domain-containing protein 1-like", "go_ids": [], "go_terms": [], "name": "ABTB1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044516": {"description": "UDP-glucuronic acid decarboxylase-like", "go_ids": ["GO:0042732", "GO:0070403"], "go_terms": ["GO:0042732:D-xylose metabolic process:P", "GO:0070403:NAD+ binding:F"], "name": "UXS-like", "pathway_ids": ["PWY-4821", "R-XTR-1971475", "R-RNO-1971475", "R-DRE-173599", "R-MMU-173599", "R-HSA-1971475", "R-XTR-173599", "R-HSA-173599", "R-MMU-1971475", "R-RNO-173599", "R-DRE-1971475"], "pathways": ["PWY-4821:t:UDP-alpha-D-xylose biosynthesis", "R-XTR-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-DRE-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-XTR-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-RNO-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DRE-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis"], "type": "Family"}, "IPR044517": {"description": "Protein PHOX1-4", "go_ids": [], "go_terms": [], "name": "PHOX1-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044518": {"description": "ADP-ribosylation factor GTPase-activating protein AGD11/12/13", "go_ids": ["GO:0005096", "GO:0005543"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0005543:phospholipid binding:F"], "name": "ARF_GAP_AGD11/12/13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044519": {"description": "ADP-ribosylation factor GTPase-activating protein AGD6/7", "go_ids": ["GO:0005096", "GO:0016192"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0016192:vesicle-mediated transport:P"], "name": "ARF_GAP_AGD6/7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044520": {"description": "ADP-ribosylation factor GTPase-activating protein AGD5/15", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "ARF_GAP_AGD5/15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044521": {"description": "Basic leucine zipper 8/43", "go_ids": [], "go_terms": [], "name": "AtbZIP8/43", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044522": {"description": "CRC domain-containing protein TSO1-like", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "TSO1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044524": {"description": "Histidine biosynthesis, HisA-like", "go_ids": ["GO:0003949", "GO:0000105"], "go_terms": ["GO:0003949:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity:F", "GO:0000105:L-histidine biosynthetic process:P"], "name": "Isoase_HisA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044525": {"description": "Digalactosyldiacylglycerol synthase 1/2", "go_ids": ["GO:0046481"], "go_terms": ["GO:0046481:digalactosyldiacylglycerol synthase activity:F"], "name": "DGDG1/2", "pathway_ids": ["PWY-401", "PWY-7840", "PWY-7666"], "pathways": ["PWY-401:t:galactolipid biosynthesis I", "PWY-7840:t:gala-series glycosphingolipids biosynthesis", "PWY-7666:t:galactolipid biosynthesis II"], "type": "Family"}, "IPR044526": {"description": "Protein SODIUM POTASSIUM ROOT DEFECTIVE 1-3", "go_ids": [], "go_terms": [], "name": "NAKR1-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044529": {"description": "Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF", "go_ids": ["GO:0031449", "GO:1901894"], "go_terms": ["GO:0031449:regulation of slow-twitch skeletal muscle fiber contraction:P", "GO:1901894:regulation of ATPase-coupled calcium transmembrane transporter activity:P"], "name": "DWORF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044530": {"description": "Chaperone protein SicP", "go_ids": ["GO:0030254"], "go_terms": ["GO:0030254:protein secretion by the type III secretion system:P"], "name": "SicP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044532": {"description": "Protein BREVIS RADIX-like", "go_ids": [], "go_terms": [], "name": "BRX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044533": {"description": "FCS-Like Zinc finger 1/2/3", "go_ids": [], "go_terms": [], "name": "FLZ1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044534": {"description": "TPR repeat-containing thioredoxin TTL1-4", "go_ids": [], "go_terms": [], "name": "TTL1-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044536": {"description": "Peroxisomal targeting signal 2 receptor", "go_ids": ["GO:0000268", "GO:0016558"], "go_terms": ["GO:0000268:peroxisome signal sequence receptor activity:F", "GO:0016558:protein import into peroxisome matrix:P"], "name": "PEX7", "pathway_ids": ["R-SPO-9033241", "R-MMU-9033241", "R-DDI-9033241", "R-HSA-9033241", "R-SCE-9033241"], "pathways": ["R-SPO-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-SCE-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR044537": {"description": "Putative zinc metalloprotease Rip2-like", "go_ids": ["GO:0008237"], "go_terms": ["GO:0008237:metallopeptidase activity:F"], "name": "Rip2-like", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR044538": {"description": "Vacuolar protein sorting-associated protein Vta1-like", "go_ids": ["GO:0032511"], "go_terms": ["GO:0032511:late endosome to vacuole transport via multivesicular body sorting pathway:P"], "name": "Vta1-like", "pathway_ids": ["R-HSA-917729", "R-HSA-162588", "R-DDI-917729", "R-MMU-917729"], "pathways": ["R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)"], "type": "Family"}, "IPR044539": {"description": "Pachytene checkpoint protein 2-like", "go_ids": [], "go_terms": [], "name": "Pch2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044542": {"description": "N-alpha-acetyltransferase 30-like", "go_ids": ["GO:0004596", "GO:0017196"], "go_terms": ["GO:0004596:protein-N-terminal amino-acid acetyltransferase activity:F", "GO:0017196:N-terminal peptidyl-methionine acetylation:P"], "name": "NAA30-like", "pathway_ids": ["PWY-7800", "R-HSA-6811440"], "pathways": ["PWY-7800:t:Ac/N-end rule pathway", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Family"}, "IPR044552": {"description": "GDSL esterase/lipase GLIP1-5/GLL25", "go_ids": [], "go_terms": [], "name": "GLIP1-5/GLL25", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Family"}, "IPR044554": {"description": "Anaphase-promoting complex subunit 2", "go_ids": [], "go_terms": [], "name": "ANAPC2", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-SPO-176408", "R-HSA-2467813", "R-MMU-2467813", "R-MMU-174154", "R-MMU-69017", "R-MMU-179409", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-CEL-983168", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-DDI-176409", "R-DDI-2559582", "R-DDI-2467813", "R-SPO-983168", "R-DDI-176412", "R-SCE-983168", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-68867", "R-DDI-174084", "R-MMU-176409", "R-SPO-2559582", "R-HSA-176409", "R-HSA-9687136", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-SPO-179409", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-DDI-174184", "R-MMU-141430", "R-HSA-69017", "R-DDI-141430", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-DDI-174178", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Family"}, "IPR044555": {"description": "Protein WUSCHEL-like", "go_ids": ["GO:0003700", "GO:0099402"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0099402:plant organ development:P"], "name": "WUSCHEL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044557": {"description": "WUSCHEL-related homeobox 8/9-like", "go_ids": ["GO:0003700", "GO:0050793"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0050793:regulation of developmental process:P"], "name": "WOX8/9-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044558": {"description": "WUSCHEL-related homeobox 11-like", "go_ids": ["GO:0003700", "GO:0048830"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0048830:adventitious root development:P"], "name": "WOX11-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044559": {"description": "WUSCHEL-related homeobox 13-like", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "WOX13-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044560": {"description": "Monooxygenase-like", "go_ids": [], "go_terms": [], "name": "MOase", "pathway_ids": ["PWY-5882", "PWY-6526", "PWY-7045", "PWY-5871", "PWY-7626", "PWY-5856", "PWY-7989", "PWY-5421", "PWY-6495", "PWY-6340", "PWY-5855", "PWY-7689", "PWY-7677", "PWY-7151", "PWY-7412", "PWY-6378", "PWY-7010", "PWY-7692", "PWY-6379", "PWY-2467", "PWY-7615", "PWY-7757", "PWY-8049", "PWY-5857", "PWY-7624", "PWY-7659", "PWY-7565", "PWY-5318", "PWY-7150", "PWY-7667", "PWY-5706", "PWY-7983", "PWY-7604", "PWY-7212", "PWY-7895", "PWY-8100", "PWY-8374", "PWY-7629", "PWY-5873", "PWY-7230", "PWY-8432", "PWY-7733", "PWY-8012", "PWY-7984", "PWY-7009", "PWY-6831", "PWY-7861", "PWY-8038", "PWY-2724", "PWY-581", "PWY-8158", "PWY-7419", "PWY-6503", "PWY-7175", "PWY-7521", "PWY-7668", "PWY-7603", "PWY-7650", "PWY-8382", "PWY-7673", "PWY-7734", "PWY-7779", "PWY-7430", "PWY-7705", "PWY-5984", "PWY-5412", "PWY-7687", "PWY-8087", "PWY-321", "PWY-8036", "PWY-7660", "PWY-7407", "PWY-7599", "PWY-7988", "PWY-7698", "PWY-2421", "PWY-7513", "PWY-8111", "PWY-5434", "PWY-6552", "PWY-7826", "PWY-7937", "PWY-5870", "PWY-7638", "PWY-5413", "PWY-8035", "PWY-5414", "PWY-7949", "PWY-7749", "PWY-1381", "PWY-7085", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-7304", "PWY-7492", "PWY-6978", "PWY-5422", "PWY-6708", "PWY-5846", "PWY-7405", "PWY-6710", "PWY-7011", "PWY-7481", "PWY-5872", "PWY-7648", "PWY-7637", "PWY-601", "PWY-761", "PWY-7775", "PWY-7708", "PWY-6971", "PWY-8085", "PWY-7780", "PWY-7703"], "pathways": ["PWY-5882:t:epoxypseudoisoeugenol-2-methylbutanoate biosynthesis", "PWY-6526:t:limonene degradation III (to perillate)", "PWY-7045:t:mithramycin biosynthesis", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-7626:t:bacilysin biosynthesis", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-5421:t:dehydroabietic acid biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-6340:t:5,5'-dehydrodivanillate degradation", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7010:t:2-propylphenol degradation", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-2467:t:(+)-pisatin biosynthesis", "PWY-7615:t:pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)", "PWY-7757:t:bisphenol A degradation", "PWY-8049:t:pederin biosynthesis", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-7624:t:nystatin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-5706:t:alliin metabolism", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7604:t:notoamide C and D biosynthesis", "PWY-7212:t:baicalein metabolism", "PWY-7895:t:ethionamide activation", "PWY-8100:t:crotonosine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-7629:t:yatein biosynthesis II", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7009:t:2,2'-dihydroxybiphenyl degradation", "PWY-6831:t:pyrrolnitrin biosynthesis", "PWY-7861:t:N-hydroxy-L-pipecolate biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-2724:t:alkane oxidation", "PWY-581:t:indole-3-acetate biosynthesis II", "PWY-8158:t:ibotenate and muscimol biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6503:t:superpathway of ergotamine biosynthesis", "PWY-7175:t:nostoxanthin biosynthesis", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation", "PWY-7668:t:apicidin F biosynthesis", "PWY-7603:t:stephacidin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-7705:t:quinolinone B biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-5412:t:levopimaric acid biosynthesis", "PWY-7687:t:stipitatate biosynthesis", "PWY-8087:t:indole-3-acetate degradation II", "PWY-321:t:cutin biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7698:t:2,5-xylenol and 3,5-xylenol degradation", "PWY-2421:t:indole-3-acetate degradation I", "PWY-7513:t:flaviolin dimer and mompain biosynthesis", "PWY-8111:t:carbaryl degradation", "PWY-5434:t:(3E)-4,8-dimethylnona-1,3,7-triene biosynthesis I", "PWY-6552:t:caffeine degradation I (main, plants)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7937:t:fungal bioluminescence", "PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-7638:t:echinenone and zeaxanthin biosynthesis (Synechocystis)", "PWY-5413:t:neoabietic acid biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5414:t:palustric acid biosynthesis", "PWY-7949:t:diadinoxanthin and diatoxanthin interconversion", "PWY-7749:t:(-)-4'-demethyl-epipodophyllotoxin biosynthesis", "PWY-1381:t:fluorene degradation II", "PWY-7085:t:triethylamine degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-7304:t:3-amino-4,7-dihydroxy-coumarin biosynthesis", "PWY-7492:t:paspaline biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-5422:t:isopimaric acid biosynthesis", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5846:t:colchicine biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6710:t:poly-hydroxy fatty acids biosynthesis", "PWY-7011:t:2-isopropylphenol degradation", "PWY-7481:t:oryzalide A biosynthesis", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-7637:t:2,2'-dihydroxyketocarotenoids biosynthesis", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7775:t:propane degradation II", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-7780:t:butane degradation", "PWY-7703:t:2,4-xylenol degradation to protocatechuate"], "type": "Family"}, "IPR044562": {"description": "Protein C2-DOMAIN ABA-RELATED", "go_ids": [], "go_terms": [], "name": "CAR1-11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044563": {"description": "Protein Sgt1-like", "go_ids": ["GO:0051087"], "go_terms": ["GO:0051087:protein-folding chaperone binding:F"], "name": "Sgt1-like", "pathway_ids": ["R-HSA-9660826", "R-SCE-844456", "R-SPO-844456", "R-DDI-844456", "R-RNO-844456", "R-MMU-844456", "R-BTA-844456", "R-HSA-844456"], "pathways": ["R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-SCE-844456:r:The NLRP3 inflammasome", "R-SPO-844456:r:The NLRP3 inflammasome", "R-DDI-844456:r:The NLRP3 inflammasome", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-BTA-844456:r:The NLRP3 inflammasome", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Family"}, "IPR044565": {"description": "Vesicle-trafficking protein Sec22", "go_ids": ["GO:0005484", "GO:0006888", "GO:0006890"], "go_terms": ["GO:0005484:SNAP receptor activity:F", "GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P", "GO:0006890:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum:P"], "name": "Sec22", "pathway_ids": ["R-HSA-204005", "R-HSA-1236974", "R-HSA-5694530", "R-HSA-6811434"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5694530:r:Cargo concentration in the ER", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR044566": {"description": "Polyamine transporter RMV1-like", "go_ids": ["GO:0022857"], "go_terms": ["GO:0022857:transmembrane transporter activity:F"], "name": "RMV1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044567": {"description": "SNF2 domain-containing protein CLSY/DRD1", "go_ids": ["GO:0080188"], "go_terms": ["GO:0080188:gene silencing by siRNA-directed DNA methylation:P"], "name": "CLSY/DRD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044570": {"description": "Histone-lysine N-methyltransferase Set1-like", "go_ids": ["GO:0042800"], "go_terms": ["GO:0042800:histone H3K4 methyltransferase activity:F"], "name": "Set1-like", "pathway_ids": ["R-MMU-8936459", "R-SCE-9772755", "R-MMU-3214841", "R-HSA-3214841", "R-DRE-3214841", "R-DME-8936459", "R-HSA-9772755", "R-DDI-9772755", "R-HSA-8936459", "R-CEL-8936459", "R-DME-9772755", "R-SPO-9772755", "R-CEL-9772755", "R-MMU-9772755", "R-CEL-3214841"], "pathways": ["R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DDI-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-3214841:r:PKMTs methylate histone lysines"], "type": "Family"}, "IPR044571": {"description": "Phosphatidylinositol 4-kinase gamma 1-8", "go_ids": [], "go_terms": [], "name": "P4KG1-8", "pathway_ids": ["PWY-6351", "PWY-6352"], "pathways": ["PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", 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"Pentatricopeptide repeat-containing protein BIR6-like", "go_ids": ["GO:0008380"], "go_terms": ["GO:0008380:RNA splicing:P"], "name": "BIR6-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044579": {"description": "Transcription factor bHLH11/121", "go_ids": ["GO:0006879", "GO:0003700"], "go_terms": ["GO:0006879:intracellular iron ion homeostasis:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "bHLH11/121", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044580": {"description": "5'-Methylthioadenosine/S-adenosylhomocysteine nucleosidase", "go_ids": ["GO:0033353", "GO:0008930"], "go_terms": ["GO:0033353:L-methionine cycle:P", "GO:0008930:methylthioadenosine nucleosidase activity:F"], "name": "MTAN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044581": {"description": "Two pore calcium channel protein 1, plant", "go_ids": ["GO:0005245"], "go_terms": ["GO:0005245:voltage-gated calcium channel activity:F"], "name": "TPC1_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044584": {"description": "E3 ubiquitin-protein ligase KEG", "go_ids": ["GO:0006952", "GO:0009738", "GO:0004842", "GO:0016567"], "go_terms": ["GO:0006952:defense response:P", "GO:0009738:abscisic acid-activated signaling pathway:P", "GO:0004842:ubiquitin-protein transferase activity:F", "GO:0016567:protein ubiquitination:P"], "name": "KEG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044585": {"description": "FCS-Like Zinc finger 10/11", "go_ids": [], "go_terms": [], "name": "FLZ10/11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044587": {"description": "Heat shock protein 21-like", "go_ids": ["GO:0009408"], "go_terms": ["GO:0009408:response to heat:P"], "name": "HSP21-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044588": {"description": "PX domain-containing protein EREX-like", "go_ids": ["GO:0015031"], "go_terms": ["GO:0015031:protein transport:P"], "name": "EREX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044589": {"description": "GATA transcription factor 26/27", "go_ids": [], "go_terms": [], "name": "GATA26/27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044590": {"description": "Probable calcium-binding protein CML48/49/50", "go_ids": [], "go_terms": [], "name": "CML48/49/50", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044591": {"description": "Microtubule-associated kinase-like protein RUNKEL", "go_ids": ["GO:0000914", "GO:0008017", "GO:0000911"], "go_terms": ["GO:0000914:phragmoplast assembly:P", "GO:0008017:microtubule binding:F", "GO:0000911:cytokinesis by cell plate formation:P"], "name": "RUK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044592": {"description": "Putative E3 ubiquitin-protein ligase RING1a/b", "go_ids": [], "go_terms": [], "name": "RING1A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044593": {"description": "FCS-Like Zinc finger 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"GO:0016740"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0016740:transferase activity:F"], "name": "ATL1/ATL16-like", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR044601": {"description": "3xHMG-box protein HMGB6/HMGB13", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "HMGB6/HMGB13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044602": {"description": "RING-H2 finger protein ATL10/ATL72-79-like", "go_ids": ["GO:0016567", "GO:0016740"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0016740:transferase activity:F"], "name": "ATL10/ATL72-79-like", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR044603": {"description": "Senescence-associated carboxylesterase 101-like", "go_ids": ["GO:0052689", "GO:0006952"], "go_terms": ["GO:0052689:carboxylic ester hydrolase activity:F", "GO:0006952:defense response:P"], "name": "SAG101-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044604": {"description": "FCS-Like Zinc finger 12/13/14", "go_ids": [], "go_terms": [], "name": "FLZ12/13/14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044605": {"description": "Pentatricopeptide repeat-containing protein At1g26460-like", "go_ids": [], "go_terms": [], "name": "At1g26460-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044606": {"description": "5'-adenylylsulfate reductase-like 4/6", "go_ids": [], "go_terms": [], "name": "APRL4/6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044607": {"description": "Transcription factor RKD-like", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "RKD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044608": {"description": "Ethanolamine-phosphate cytidylyltransferase", "go_ids": ["GO:0004306", "GO:0006646"], "go_terms": ["GO:0004306:ethanolamine-phosphate cytidylyltransferase activity:F", "GO:0006646:phosphatidylethanolamine biosynthetic process:P"], "name": "Ect1/PCYT2", "pathway_ids": ["PWY-7782", "R-SCE-1483213", "R-HSA-1483213", "R-MMU-1483213", "R-RNO-1483213", "R-DDI-1483213", "R-SPO-1483213"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "R-SCE-1483213:r:Synthesis of PE", "R-HSA-1483213:r:Synthesis of PE", "R-MMU-1483213:r:Synthesis of PE", "R-RNO-1483213:r:Synthesis of PE", "R-DDI-1483213:r:Synthesis of PE", "R-SPO-1483213:r:Synthesis of PE"], "type": "Family"}, "IPR044609": {"description": "Peptidyl-prolyl cis-trans isomerase FKBP2/11", "go_ids": ["GO:0003755", "GO:0000413"], "go_terms": ["GO:0003755:peptidyl-prolyl cis-trans isomerase activity:F", "GO:0000413:protein peptidyl-prolyl isomerization:P"], "name": "FKBP2/11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044610": {"description": "Beta-glucuronosyltransferase GlcAT14A/B/C", "go_ids": ["GO:0015020"], 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"PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O 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"PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR044611": {"description": "Ubiquitin-protein ligase E3A/B/C-like", "go_ids": ["GO:0061630", "GO:0000209"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0000209:protein polyubiquitination:P"], "name": "E3A/B/C-like", "pathway_ids": ["PWY-7511", "R-SPO-983168", "R-SCE-983168", "R-HSA-983168", "R-XTR-983168", "R-CEL-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR044612": {"description": "ADP-ribosylation factor-like protein 2/3", "go_ids": ["GO:0003924"], "go_terms": ["GO:0003924:GTPase activity:F"], "name": "ARL2/3", "pathway_ids": ["R-CEL-9648002", "R-DRE-5624138", "R-RNO-83936", "R-HSA-83936", "R-MMU-9648002", "R-BTA-9648002", "R-MMU-5624138", "R-RNO-5624138", "R-HSA-5624138", "R-BTA-83936", "R-RNO-9648002", "R-HSA-389977", "R-HSA-9648002", "R-MMU-83936", "R-CEL-5624138", "R-DME-9648002"], "pathways": ["R-CEL-9648002:r:RAS processing", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-RNO-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-HSA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-MMU-9648002:r:RAS processing", "R-BTA-9648002:r:RAS processing", "R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-RNO-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-BTA-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-RNO-9648002:r:RAS processing", "R-HSA-389977:r:Post-chaperonin tubulin folding pathway", "R-HSA-9648002:r:RAS processing", "R-MMU-83936:r:Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "R-CEL-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-DME-9648002:r:RAS processing"], "type": "Family"}, "IPR044613": {"description": "NEDD8-specific protease 1/2-like", "go_ids": ["GO:0019784"], "go_terms": ["GO:0019784:deNEDDylase activity:F"], "name": "Nep1/2-like", "pathway_ids": ["R-MMU-8951664", "R-RNO-5689603", "R-RNO-8951664", "R-HSA-8951664", "R-DDI-6791226", "R-SPO-8951664", "R-HSA-5689603", "R-MMU-5689603", "R-DDI-3065679", "R-SPO-5689603"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-RNO-5689603:r:UCH proteinases", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-8951664:r:Neddylation", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-DDI-3065679:r:SUMO is proteolytically processed", "R-SPO-5689603:r:UCH proteinases"], "type": "Family"}, "IPR044614": {"description": "Rhodanese-like domain-containing protein 10", "go_ids": [], "go_terms": [], "name": "STR10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044615": {"description": "Rhodanese-like domain-containing protein 9, chloroplastic", "go_ids": [], "go_terms": [], "name": "STR9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044616": {"description": "WD repeat-containing protein RUP1/2", "go_ids": [], "go_terms": [], "name": "RUP1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044617": {"description": "Tetrachlorohydroquinone dehalogenase", "go_ids": ["GO:0004364"], "go_terms": ["GO:0004364:glutathione transferase activity:F"], "name": "TCHQD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044618": {"description": "NAD(P)H-quinone oxidoreductase subunit T-like", "go_ids": [], "go_terms": [], "name": "NdhT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044621": {"description": "Protein NEDD1", "go_ids": ["GO:0140496", "GO:0010968"], "go_terms": ["GO:0140496:gamma-tubulin complex binding:F", "GO:0010968:regulation of microtubule nucleation:P"], "name": "NEDD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044622": {"description": "WD repeat-containing protein PCN", "go_ids": ["GO:0035266", "GO:0010073"], "go_terms": ["GO:0035266:meristem growth:P", "GO:0010073:meristem maintenance:P"], "name": "PCN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044623": {"description": "ERAD-associated E3 ubiquitin-protein ligase component HRD3", "go_ids": ["GO:0036503"], "go_terms": ["GO:0036503:ERAD pathway:P"], "name": "HRD3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044624": {"description": "Tetratricopeptide-like repeat protein Mbb1-like", "go_ids": ["GO:0006397", "GO:0003729"], "go_terms": ["GO:0006397:mRNA processing:P", "GO:0003729:mRNA binding:F"], "name": "Mbb1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044626": {"description": "NADPH-dependent oxidoreductase AOR-like", "go_ids": ["GO:0016628"], "go_terms": ["GO:0016628:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor:F"], "name": "AOR-like", "pathway_ids": ["PWY-5975", "PWY-7910"], "pathways": ["PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7910:t:homofuraneol biosynthesis"], "type": "Family"}, "IPR044627": {"description": "Dehydroascorbate reductases DHAR1/2/3/4", "go_ids": ["GO:0098869", "GO:0033355", "GO:0045174"], "go_terms": ["GO:0098869:cellular oxidant detoxification:P", "GO:0033355:ascorbate glutathione cycle:P", "GO:0045174:glutathione dehydrogenase (ascorbate) activity:F"], "name": "DHAR1/2/3/4", "pathway_ids": ["PWY-7533", "PWY-4061", "PWY-6842", "PWY-6370", "PWY-2261", "PWY-7112"], "pathways": ["PWY-7533:t:gliotoxin biosynthesis", "PWY-4061:t:glutathione-mediated detoxification I", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6370:t:ascorbate recycling (cytosolic)", "PWY-2261:t:ascorbate glutathione cycle", "PWY-7112:t:4-hydroxy-2-nonenal detoxification"], "type": "Family"}, "IPR044628": {"description": "Elongation factor 1-gamma, plant", "go_ids": ["GO:0004364"], "go_terms": ["GO:0004364:glutathione transferase activity:F"], "name": "EF-1-gamma_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044629": {"description": "Glutathione S-transferase L1/2/3", "go_ids": ["GO:0004364"], "go_terms": ["GO:0004364:glutathione transferase activity:F"], "name": "GSTL1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044630": {"description": "WD-repeat protein SPA1/2/3/4", "go_ids": ["GO:0009640"], "go_terms": ["GO:0009640:photomorphogenesis:P"], "name": "SPA1/2/3/4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044631": {"description": "ETO1-like", "go_ids": ["GO:0010105"], "go_terms": ["GO:0010105:negative regulation of ethylene-activated signaling pathway:P"], "name": "ETO1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044632": {"description": "DnaJ homolog subfamily C member 25-like", "go_ids": ["GO:0006457"], "go_terms": ["GO:0006457:protein folding:P"], "name": "DNAJC25-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044633": {"description": "Cleavage stimulation factor subunit 1-like", "go_ids": ["GO:0031124", "GO:0005848"], "go_terms": ["GO:0031124:mRNA 3'-end processing:P", "GO:0005848:mRNA cleavage stimulating factor complex:C"], "name": "CstF1-like", "pathway_ids": ["R-RNO-73856", "R-HSA-77595", "R-MMU-72187", "R-HSA-9770562", "R-MMU-9770562", "R-RNO-9770562", "R-MMU-77595", "R-HSA-73856", "R-RNO-77595", "R-MMU-73856", "R-HSA-72187", "R-HSA-9918481"], "pathways": ["R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR044634": {"description": "J-protein Zuotin/DnaJC2", "go_ids": ["GO:0030544", "GO:0051083", "GO:0043022", "GO:0006450"], "go_terms": ["GO:0030544:Hsp70 protein binding:F", "GO:0051083:'de novo' cotranslational protein folding:P", "GO:0043022:ribosome binding:F", "GO:0006450:regulation of translational fidelity:P"], "name": "Zuotin/DnaJC2", "pathway_ids": ["R-SCE-3371453", "R-XTR-3371453", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-DRE-3371453", "R-BTA-3371453", "R-MMU-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Family"}, "IPR044635": {"description": "Ubiquitin carboxyl-terminal hydrolase 14-like", "go_ids": ["GO:0004843", "GO:0016579", "GO:0043161"], "go_terms": ["GO:0004843:cysteine-type deubiquitinase activity:F", "GO:0016579:protein deubiquitination:P", "GO:0043161:proteasome-mediated ubiquitin-dependent protein catabolic process:P"], "name": "UBP14-like", "pathway_ids": ["R-CEL-5689880", "R-MMU-5689880", "R-BTA-9758274", "R-BTA-5689880", "R-HSA-5689880", "R-HSA-9758274", "R-MMU-9758274", "R-SCE-5689880", "R-SPO-5689880"], "pathways": ["R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-SCE-5689880:r:Ub-specific processing proteases", "R-SPO-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR044636": {"description": "Transcription factor RADIALIS-like", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "RADIALIS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044638": {"description": "Aldehyde dehydrogenase family 7 member A1-like", "go_ids": ["GO:0004029"], "go_terms": ["GO:0004029:aldehyde dehydrogenase (NAD+) activity:F"], "name": "ALDH7A1-like", "pathway_ids": ["PWY-6307", "PWY-7119", "PWY-6313", "PWY-2724", "PWY-2501", "PWY-8029", "PWY-7387", "PWY-6181", "PWY-6342", "PWY-7269", "PWY-7431", "PWY-0", "R-HSA-6798163", "R-MMU-71064", "R-RNO-6798163", "R-CEL-71064", "R-HSA-71064", "R-MMU-6798163", "R-DRE-6798163", "R-DDI-6798163", "R-DRE-71064", "R-DDI-71064", "R-RNO-71064", "R-CEL-6798163"], "pathways": ["PWY-6307:t:L-tryptophan degradation X (mammalian, via tryptamine)", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6313:t:serotonin degradation", "PWY-2724:t:alkane oxidation", "PWY-2501:t:fatty acid alpha-oxidation I (plants)", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-7387:t:hypotaurine degradation", "PWY-6181:t:histamine degradation", "PWY-6342:t:noradrenaline and adrenaline degradation", "PWY-7269:t:mitochondrial NADPH production (yeast)", "PWY-7431:t:aromatic biogenic amine degradation (bacteria)", "PWY-0:t:putrescine degradation III", "R-HSA-6798163:r:Choline catabolism", "R-MMU-71064:r:Lysine catabolism", "R-RNO-6798163:r:Choline catabolism", "R-CEL-71064:r:Lysine catabolism", "R-HSA-71064:r:Lysine catabolism", "R-MMU-6798163:r:Choline catabolism", "R-DRE-6798163:r:Choline catabolism", "R-DDI-6798163:r:Choline catabolism", "R-DRE-71064:r:Lysine catabolism", "R-DDI-71064:r:Lysine catabolism", "R-RNO-71064:r:Lysine catabolism", "R-CEL-6798163:r:Choline catabolism"], "type": "Family"}, "IPR044639": {"description": "Cystathionine gamma-synthase 1/2", "go_ids": ["GO:0003962"], "go_terms": ["GO:0003962:cystathionine gamma-synthase activity:F"], "name": "CGS1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044640": {"description": "U2 small nuclear ribonucleoprotein A'", "go_ids": ["GO:0000398", "GO:0030620"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P", "GO:0030620:U2 snRNA binding:F"], "name": "RU2A", "pathway_ids": ["R-DME-9770562", "R-HSA-72163", "R-SPO-9770562", "R-HSA-9770562", "R-CEL-9770562", "R-MMU-9770562", "R-MMU-72163", "R-DME-72163", "R-HSA-8950505", "R-CEL-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR044641": {"description": "Sm-like protein Lsm7/SmG", "go_ids": [], "go_terms": [], "name": "Lsm7/SmG-like", "pathway_ids": ["R-MMU-191859", "R-DDI-430039", "R-BTA-72163", "R-SPO-430039", "R-BTA-111367", "R-HSA-430039", "R-HSA-9770562", 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["GO:0000278:mitotic cell cycle:P", "GO:0048527:lateral root development:P"], "name": "WPP1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044693": {"description": "Shugoshin, plant", "go_ids": ["GO:0045144", "GO:0034090", "GO:0000775"], "go_terms": ["GO:0045144:meiotic sister chromatid segregation:P", "GO:0034090:maintenance of meiotic sister chromatid cohesion:P", "GO:0000775:chromosome, centromeric region:C"], "name": "SGO_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044694": {"description": "Nuclear pore complex protein NUP214", "go_ids": ["GO:0006405", "GO:0017056"], "go_terms": ["GO:0006405:RNA export from nucleus:P", "GO:0017056:structural constituent of nuclear pore:F"], "name": "NUP214", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044695": {"description": "Small ribosomal subunit protein bTHXc/bTHXc, plant", "go_ids": [], "go_terms": [], "name": "Ribosomal_bTHXc/bTHXc_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044696": {"description": "WPP domain-interacting protein 1/2/3", "go_ids": [], "go_terms": [], "name": "WIP1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044699": {"description": "Membrane-associated kinase regulator 6", "go_ids": [], "go_terms": [], "name": "MAKR6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044700": {"description": "PIP2/PIPL1", "go_ids": ["GO:0045087", "GO:0050793"], "go_terms": ["GO:0045087:innate immune response:P", "GO:0050793:regulation of developmental process:P"], "name": "PIP2/PIPL1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044701": {"description": "Thioredoxin-like fold domain-containing protein MRL7/MRL7L", "go_ids": ["GO:0009658", "GO:0006355"], "go_terms": ["GO:0009658:chloroplast organization:P", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "MRL7/MRL7L", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044702": {"description": "Arabinogalactan protein 23/40", "go_ids": [], "go_terms": [], "name": "AGP23/40", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044705": {"description": "COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB4", "go_ids": [], "go_terms": [], "name": "CCB4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044706": {"description": "AUGMIN subunit 5, plant", "go_ids": ["GO:0005876"], "go_terms": ["GO:0005876:spindle microtubule:C"], "name": "AUG5_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044708": {"description": "Constitutive expression of pathogenesis-related genes 5", "go_ids": ["GO:0006952", "GO:0010090", "GO:0010150"], "go_terms": ["GO:0006952:defense response:P", "GO:0010090:trichome morphogenesis:P", "GO:0010150:leaf senescence:P"], "name": "CPR5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044709": {"description": "Microtubule-binding protein TANGLED1", "go_ids": ["GO:0008017", "GO:2000694"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:2000694:regulation of phragmoplast microtubule organization:P"], "name": "TAN1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044710": {"description": "PLASTID TRANSCRIPTIONALLY ACTIVE protein 6", "go_ids": ["GO:0000427"], "go_terms": ["GO:0000427:plastid-encoded plastid RNA polymerase complex:C"], "name": "PTAC6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044711": {"description": "Egg cell-secreted protein 1.1-1.5", "go_ids": ["GO:0009567"], "go_terms": ["GO:0009567:double fertilization forming a zygote and endosperm:P"], "name": "EC11-15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044712": {"description": "NAD/FAD transporter SLC25A32-like", "go_ids": ["GO:0055085", "GO:0006862"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0006862:nucleotide transport:P"], "name": "SLC25A32-like", "pathway_ids": ["R-SCE-196757", "R-DDI-196757", "R-SPO-196757", "R-MMU-196757", "R-HSA-196757"], "pathways": ["R-SCE-196757:r:Metabolism of folate and pterines", "R-DDI-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-MMU-196757:r:Metabolism of folate and pterines", "R-HSA-196757:r:Metabolism of folate and pterines"], "type": "Family"}, "IPR044713": {"description": "DnaJ homolog subfamily A member 1/2-like", "go_ids": ["GO:0030544", "GO:0006457"], "go_terms": ["GO:0030544:Hsp70 protein binding:F", "GO:0006457:protein folding:P"], "name": "DNJA1/2-like", "pathway_ids": ["R-SPO-3371497", "R-SCE-3371497", "R-DDI-3371497", "R-MMU-9841251", "R-SPO-9841251", "R-HSA-9841251", "R-BTA-3371497", "R-HSA-9918487", "R-RNO-3371497", "R-SCE-9841251", "R-HSA-3371497", "R-RNO-9841251", "R-BTA-9841251", "R-MMU-3371497"], "pathways": ["R-SPO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DDI-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-SPO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SCE-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-BTA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "type": "Family"}, "IPR044714": {"description": "BTB/POZ domain-containing protein AtSIBP1-like", "go_ids": [], "go_terms": [], "name": "AtSIBP1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044715": {"description": "WD repeat-containing protein 86-like", "go_ids": [], "go_terms": [], "name": "WDR86-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044716": {"description": "Transcriptional corepressor LEUNIG-like", "go_ids": ["GO:0003714"], "go_terms": ["GO:0003714:transcription corepressor activity:F"], "name": "LEUNIG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044717": {"description": "Nicotinamidase 1", "go_ids": ["GO:0008936", "GO:0019365"], "go_terms": ["GO:0008936:nicotinamidase activity:F", "GO:0019365:pyridine nucleotide salvage:P"], "name": "NIC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044718": {"description": "E3 ubiquitin-protein ligase HOS1", "go_ids": ["GO:0016567", "GO:0004842"], "go_terms": ["GO:0016567:protein ubiquitination:P", "GO:0004842:ubiquitin-protein transferase activity:F"], "name": "HOS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044719": {"description": "Protein TIC 62-like", "go_ids": [], "go_terms": [], "name": "TIC62", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044720": {"description": "Small ribosomal subunit protein aS21", "go_ids": [], "go_terms": [], "name": "RS21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044722": {"description": "SecA, C-terminal helicase domain", "go_ids": [], "go_terms": [], "name": "SecA_SF2_C", "pathway_ids": ["R-HSA-9760173", "R-HSA-9636383", "R-HSA-1222387"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Domain"}, "IPR044731": {"description": "Butanol dehydrogenase-like", "go_ids": ["GO:1990362"], "go_terms": ["GO:1990362:butanol dehydrogenase (NAD+) activity:F"], "name": "BDH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044770": {"description": "Protein spinster-like", "go_ids": [], "go_terms": [], "name": "MFS_spinster-like", "pathway_ids": ["R-DRE-1660661", "R-HSA-1660661", "R-DME-1660661", "R-XTR-1660661", "R-MMU-1660661"], "pathways": ["R-DRE-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-XTR-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR044772": {"description": "Nitrate transporter", "go_ids": ["GO:0015112"], "go_terms": ["GO:0015112:nitrate transmembrane transporter activity:F"], "name": "NO3_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044780": {"description": "Heh2/Src1-like", "go_ids": ["GO:0003682", "GO:0005637"], "go_terms": ["GO:0003682:chromatin binding:F", "GO:0005637:nuclear inner membrane:C"], "name": "Heh2/Src1", "pathway_ids": ["R-SCE-9668328", "R-SPO-9668328"], "pathways": ["R-SCE-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-SPO-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III"], "type": "Family"}, "IPR044781": {"description": "Pentatricopeptide repeat-containing protein At5g10690-like", "go_ids": [], "go_terms": [], "name": "At5g10690-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044782": {"description": "Sialyltransferase-like protein 1/5", "go_ids": ["GO:0008373", "GO:0009860", "GO:0009846"], "go_terms": ["GO:0008373:sialyltransferase activity:F", "GO:0009860:pollen tube growth:P", "GO:0009846:pollen germination:P"], "name": "SIA1/STLP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044783": {"description": "Phytolongin", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "PHYL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044784": {"description": "BTB/POZ domain containing protein At1g01640-like", "go_ids": [], "go_terms": [], "name": "At1g01640-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044785": {"description": "Rho GTPase-activating protein 1-5", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "RopGAP1-5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044787": {"description": "HHO5-like", "go_ids": ["GO:0006355", "GO:0003700"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "HHO5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044788": {"description": "Carbohydrate-binding X8 domain-containing protein, plant", "go_ids": [], "go_terms": [], "name": "X8_dom_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044789": {"description": "Putative alpha 1,4-glycosyltransferase, plant", "go_ids": [], "go_terms": [], "name": "Put_A1-4-GlycosylTfrase_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044790": {"description": "Mediator of RNA polymerase II transcription subunit 26c-like", "go_ids": [], "go_terms": [], "name": "MD26C-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044791": {"description": "Beta-glucanase/XTH", "go_ids": ["GO:0004553"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "Beta-glucanase/XTH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044792": {"description": "Protein TAR1", "go_ids": ["GO:0043457"], "go_terms": ["GO:0043457:regulation of cellular respiration:P"], "name": "TAR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044793": {"description": "E3 ubiquitin-protein ligase SIS3", "go_ids": ["GO:0010182", "GO:0004842"], "go_terms": ["GO:0010182:sugar mediated signaling pathway:P", "GO:0004842:ubiquitin-protein transferase activity:F"], "name": "SIS3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044794": {"description": "5'-adenylylsulfate reductase-like 5/7", "go_ids": [], "go_terms": [], "name": "APRL5/7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044795": {"description": "Pentatricopeptide repeat-containing protein THA8L-like", "go_ids": [], "go_terms": [], "name": "THA8L-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044796": {"description": "Protein MLN51 homolog, plant", "go_ids": ["GO:0003729", "GO:0006397", "GO:0035145"], "go_terms": ["GO:0003729:mRNA binding:F", "GO:0006397:mRNA processing:P", "GO:0035145:exon-exon junction complex:C"], "name": "MLN51_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044797": {"description": "Uncharacterized protein At4g06598-like", "go_ids": [], "go_terms": [], "name": "At4g06598-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044798": {"description": "Chromatin modification-related protein EAF1A/B", "go_ids": ["GO:0035267"], "go_terms": ["GO:0035267:NuA4 histone acetyltransferase complex:C"], "name": "EAF1A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044799": {"description": "NAC domain-containing protein SOG1-like", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "SOG1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044800": {"description": "B3 domain-containing transcription factor LEC2-like", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "LEC2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044801": {"description": "Filamin family", "go_ids": ["GO:0030036", "GO:0051015"], "go_terms": ["GO:0030036:actin cytoskeleton organization:P", "GO:0051015:actin filament binding:F"], "name": "Filamin", "pathway_ids": ["R-HSA-114608", "R-MMU-446353", "R-HSA-8983711", "R-HSA-5627123", "R-RNO-446353", "R-HSA-446353", "R-MMU-430116", "R-DME-114608", "R-HSA-430116", "R-DME-5627123", "R-MMU-5627123", "R-DME-446353", "R-HSA-1169408", "R-MMU-1169408", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-RNO-446353:r:Cell-extracellular matrix interactions", "R-HSA-446353:r:Cell-extracellular matrix interactions", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-DME-114608:r:Platelet degranulation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-DME-446353:r:Cell-extracellular matrix interactions", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR044802": {"description": "Calmodulin calcium-dependent NAD kinase NADKc-like", "go_ids": [], "go_terms": [], "name": "NADKc-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044804": {"description": "Large ribosomal subunit protein eL20z-like", "go_ids": [], "go_terms": [], "name": "Ribosomal_eL20z-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044806": {"description": "Protein WAVE-DAMPENED 2-like", "go_ids": ["GO:0008017", "GO:0000226"], "go_terms": ["GO:0008017:microtubule binding:F", "GO:0000226:microtubule cytoskeleton organization:P"], "name": "WVD2/WDL1-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044807": {"description": "E3 ubiquitin protein ligase DRIP1-like", "go_ids": ["GO:0004842"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F"], "name": "DRIP1-like", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR044808": {"description": "Ethylene-responsive transcription factor", "go_ids": ["GO:0009873", "GO:0003700"], "go_terms": ["GO:0009873:ethylene-activated signaling pathway:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "ERF_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044809": {"description": "F-box protein AUF1-like", "go_ids": [], "go_terms": [], "name": "AUF1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044810": {"description": "WRKY transcription factor, plant", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "WRKY_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044811": {"description": "DNA glycosylase, plant", "go_ids": ["GO:0035514", "GO:0019104", "GO:0141166"], "go_terms": ["GO:0035514:DNA demethylase activity:F", "GO:0019104:DNA N-glycosylase activity:F", "GO:0141166:chromosomal 5-methylcytosine DNA demethylation pathway:P"], "name": "DME/ROS1", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Family"}, "IPR044812": {"description": "LysM domain receptor kinase CERK1/LYK3-like", "go_ids": ["GO:0045087", "GO:0019199"], "go_terms": ["GO:0045087:innate immune response:P", "GO:0019199:transmembrane receptor protein kinase activity:F"], "name": "CERK1/LYK3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044813": {"description": "Acyl carrier protein, chloroplastic", "go_ids": ["GO:0006633", "GO:0000036"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P", "GO:0000036:acyl carrier activity:F"], "name": "ACP_chloroplastic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044816": {"description": "BURP domain-containing protein", "go_ids": [], "go_terms": [], "name": "BURP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044817": {"description": "Squamosa promoter-binding-like protein", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "SBP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044818": {"description": "Transcription factor ILR3-like", "go_ids": ["GO:0003700", "GO:0006355", "GO:0006879", "GO:0046983"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0006879:intracellular iron ion homeostasis:P", "GO:0046983:protein dimerization activity:F"], "name": "ILR3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044819": {"description": "Triacylglycerol lipase OBL1-like", "go_ids": ["GO:0006629", "GO:0004806"], "go_terms": ["GO:0006629:lipid metabolic process:P", "GO:0004806:triacylglycerol lipase activity:F"], "name": "OBL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044820": {"description": "ADP-ribosylation factor GTPase-activating protein AGD14-like", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "AGD14-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044821": {"description": "Putative nucleotide-diphospho-sugar transferase At1g28695/At4g15970-like", "go_ids": [], "go_terms": [], "name": "At1g28695/At4g15970-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044822": {"description": "Myb/SANT-like DNA-binding domain 4", "go_ids": [], "go_terms": [], "name": "Myb_DNA-bind_4", "pathway_ids": ["R-HSA-212436"], "pathways": ["R-HSA-212436:r:Generic Transcription Pathway"], "type": "Domain"}, "IPR044823": {"description": "Trihelix transcription factor ASIL1/2-like", "go_ids": [], "go_terms": [], "name": "ASIL1/2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044824": {"description": "Protein MAINTENANCE OF MERISTEMS-like", "go_ids": ["GO:0048507", "GO:0010073"], "go_terms": ["GO:0048507:meristem development:P", "GO:0010073:meristem maintenance:P"], "name": "MAIN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044825": {"description": "Transcription activator GLK1/2-like", "go_ids": ["GO:0003700", "GO:0045893"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0045893:positive regulation of DNA-templated transcription:P"], "name": "GLK1/2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044827": {"description": "G-box-binding factor-like", "go_ids": ["GO:0043565", "GO:0006355", "GO:0003700"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "GBF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044828": {"description": "Stem-specific protein TSJT1-like", "go_ids": [], "go_terms": [], "name": "TSJT1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044830": {"description": "Class III homeodomain-leucine zipper family", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "HD-Zip_III", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044831": {"description": "Heme-binding peroxidase Ccp1-like", "go_ids": ["GO:0034599", "GO:0004601"], "go_terms": ["GO:0034599:cellular response to oxidative stress:P", "GO:0004601:peroxidase activity:F"], "name": "Ccp1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044832": {"description": "DCD domain-containing protein NRP-like", "go_ids": ["GO:0034976"], "go_terms": ["GO:0034976:response to endoplasmic reticulum stress:P"], "name": "NRP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044833": {"description": "Protein WVD2-like 5/6", "go_ids": ["GO:0008017"], "go_terms": ["GO:0008017:microtubule binding:F"], "name": "WDL5/6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044834": {"description": "Patellin", "go_ids": 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"Family"}, "IPR044852": {"description": "WW domain-binding protein 2-like", "go_ids": ["GO:0003713"], "go_terms": ["GO:0003713:transcription coactivator activity:F"], "name": "WBP2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044853": {"description": "IrrE, HTH domain", "go_ids": [], "go_terms": [], "name": "G3DSA:1.10.10.1030", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044854": {"description": "IraM/PmrD", "go_ids": [], "go_terms": [], "name": "IraM/PmrD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044855": {"description": "CoA-transferase family III domain 3 superfamily", "go_ids": [], "go_terms": [], "name": "CoA-Trfase_III_dom3_sf", "pathway_ids": ["R-RNO-9033241", "R-MMU-389887", "R-RNO-193775", "R-HSA-193775", "R-MMU-193368", "R-RNO-389887", "R-MMU-193775", "R-RNO-193368", "R-HSA-389887", "R-HSA-193368", "R-MMU-9033241", "R-HSA-9033241"], "pathways": ["R-RNO-9033241:r:Peroxisomal protein import", 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"R-RNO-8951664:r:Neddylation", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DRE-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-9907900:r:Proteasome assembly", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-9907900:r:Proteasome assembly", "R-RNO-4641257:r:Degradation of AXIN", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DRE-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DRE-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-DRE-9932298:r:Degradation of CRY and PER proteins", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DRE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DRE-5632684:r:Hedgehog 'on' state", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-5632684:r:Hedgehog 'on' state", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9907900:r:Proteasome assembly", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-5658442:r:Regulation 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"UbiA_sf", "pathway_ids": ["R-SPO-2142789", "R-DDI-1268020", "R-MMU-189451", "R-DME-6806664", "R-RNO-2142789", "R-MMU-2142789", "R-DME-2142789", "R-SCE-189451", "R-XTR-6806664", "R-DDI-189451", "R-HSA-189451", "R-HSA-6806664", "R-MMU-6806664", "R-SCE-2142789", "R-DME-1268020", "R-SPO-189451", "R-HSA-1268020", "R-DDI-2142789", "R-MMU-1268020", "R-RNO-6806664", "R-HSA-2142789", "R-CEL-1268020", "R-DRE-6806664", "R-CEL-2142789", "R-RNO-1268020"], "pathways": ["R-SPO-2142789:r:Ubiquinol biosynthesis", "R-DDI-1268020:r:Mitochondrial protein import", "R-MMU-189451:r:Heme biosynthesis", "R-DME-6806664:r:Metabolism of vitamin K", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-XTR-6806664:r:Metabolism of vitamin K", "R-DDI-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis", "R-HSA-6806664:r:Metabolism of vitamin K", "R-MMU-6806664:r:Metabolism of vitamin K", "R-SCE-2142789:r:Ubiquinol biosynthesis", "R-DME-1268020:r:Mitochondrial protein import", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-1268020:r:Mitochondrial protein import", "R-DDI-2142789:r:Ubiquinol biosynthesis", "R-MMU-1268020:r:Mitochondrial protein import", "R-RNO-6806664:r:Metabolism of vitamin K", "R-HSA-2142789:r:Ubiquinol biosynthesis", "R-CEL-1268020:r:Mitochondrial protein import", "R-DRE-6806664:r:Metabolism of vitamin K", "R-CEL-2142789:r:Ubiquinol biosynthesis", "R-RNO-1268020:r:Mitochondrial protein import"], "type": "Homologous_superfamily"}, "IPR044880": {"description": "NCX, central ion-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "NCX_ion-bd_dom_sf", "pathway_ids": ["R-CEL-425561", "R-DME-425561", "R-HSA-5619036", "R-RNO-5578775", "R-HSA-425561", "R-HSA-2485179", "R-RNO-418359", "R-MMU-5578775", "R-MMU-8949215", "R-RNO-425561", "R-SPO-8949215", "R-MMU-425561", "R-SCE-425561", "R-SPO-425561", "R-HSA-8949215", "R-HSA-5619077", "R-MMU-418359", "R-SCE-8949215", "R-HSA-5578775", "R-RNO-8949215", "R-HSA-5619055", "R-CEL-8949215", "R-HSA-418359"], "pathways": ["R-CEL-425561:r:Sodium/Calcium exchangers", "R-DME-425561:r:Sodium/Calcium exchangers", "R-HSA-5619036:r:Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-425561:r:Sodium/Calcium exchangers", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-RNO-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-8949215:r:Mitochondrial calcium ion transport", "R-RNO-425561:r:Sodium/Calcium exchangers", "R-SPO-8949215:r:Mitochondrial calcium ion transport", "R-MMU-425561:r:Sodium/Calcium exchangers", "R-SCE-425561:r:Sodium/Calcium exchangers", "R-SPO-425561:r:Sodium/Calcium exchangers", "R-HSA-8949215:r:Mitochondrial calcium ion transport", "R-HSA-5619077:r:Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)", "R-MMU-418359:r:Reduction of cytosolic Ca++ levels", "R-SCE-8949215:r:Mitochondrial calcium ion transport", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-8949215:r:Mitochondrial calcium ion transport", "R-HSA-5619055:r:Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)", "R-CEL-8949215:r:Mitochondrial calcium ion transport", "R-HSA-418359:r:Reduction of cytosolic Ca++ levels"], "type": "Homologous_superfamily"}, "IPR044881": {"description": "RecQ-mediated genome instability protein 1, N-terminal helical domain superfamily", "go_ids": [], "go_terms": [], "name": "RMI1_N_N_sf", "pathway_ids": ["R-DRE-5693607", "R-BTA-69473", "R-BTA-5685938", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-DRE-5693568", "R-HSA-9709570", "R-HSA-5693607", "R-BTA-6804756", "R-BTA-5693616", "R-BTA-5693579", "R-BTA-5693607", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-BTA-5693568", "R-HSA-69473", "R-MMU-5685942", "R-DRE-5685942", "R-HSA-9709603", "R-HSA-6804756", "R-DRE-69473", "R-HSA-9704331", "R-BTA-5685942", "R-DRE-5693616", "R-HSA-5693554", "R-HSA-5693579", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Homologous_superfamily"}, "IPR044882": {"description": "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily", "go_ids": [], "go_terms": [], "name": "I2BP1/2_C3HC4-RING_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044883": {"description": "Hemolysin, pre-stem domain", "go_ids": [], "go_terms": [], "name": "Hemolysin_pre-stem_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044884": {"description": "Large ribosomal subunit protein mL55 superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_mL55_sf", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-DME-9937383"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Homologous_superfamily"}, "IPR044885": {"description": "Plasmodium RESA, N-terminal helical domain superfamily", "go_ids": [], "go_terms": [], "name": "PRESA_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044886": {"description": "Folliculin, DENN domain, C-terminal superfamily", "go_ids": [], "go_terms": [], "name": "FLCN_DENN_C_sf", "pathway_ids": ["R-RNO-9639288", "R-MMU-9639288", "R-HSA-9639288", "R-XTR-9639288", "R-BTA-9639288"], "pathways": ["R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-BTA-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR044887": {"description": "Putative substrate of the Dot/Icm secretion system superfamily", "go_ids": [], "go_terms": [], "name": "SoDot-IcmSS_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044888": {"description": "Mediator complex, subunit Med7 superfmaily", "go_ids": [], "go_terms": [], "name": "Mediatior_Med7_sf", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Homologous_superfamily"}, "IPR044889": {"description": "Secreted effector protein EspF(U) superfamily", "go_ids": [], "go_terms": [], "name": "EspF(U)_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044890": {"description": "TMEM14 superfamily", "go_ids": [], "go_terms": [], "name": "TMEM14_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044891": {"description": "Histone chaperone Rtt106, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Rtt106_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044892": {"description": "Ribosomal protein L3, domain 3, archaeal-type superfamily", "go_ids": [], "go_terms": [], "name": "Ribosomal_L3_dom_3_arc_sf", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-RNO-975957", "R-SPO-9954709", "R-MMU-6791226", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-SSC-9954714", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-SSC-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SSC-72689", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-72689", "R-SCE-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SSC-9954716", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-DDI-9954716", "R-SCE-1799339", "R-SPO-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-SSC-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) 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Promoter", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-CEL-6803529:r:FGFR2 alternative splicing"], "type": "Homologous_superfamily"}, "IPR044894": {"description": "TubC, N-terminal docking domain superfamily", "go_ids": [], "go_terms": [], "name": "TubC_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044895": {"description": "Kinetochore null protein 2, Myb-like DNA-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "Knl-2_Myb-like_DNA-bd_sf", "pathway_ids": ["R-CEL-69273"], "pathways": ["R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition"], "type": "Homologous_superfamily"}, "IPR044896": {"description": "Hepatitis C virus core protein, chain A superfamily", "go_ids": [], "go_terms": [], "name": "HCV_core_chain_A", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Homologous_superfamily"}, "IPR044897": {"description": "Inositol polyphosphate 1-phosphatase, domain 1", "go_ids": [], "go_terms": [], "name": "INPP1_dom_1", "pathway_ids": ["PWY-6363", "R-HSA-1855183", "R-BTA-1855183", "R-MMU-1855183"], "pathways": ["PWY-6363:t:D-myo-inositol (1,4,5)-trisphosphate degradation", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-BTA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol"], "type": "Homologous_superfamily"}, "IPR044898": {"description": "Cyclin-dependent kinase inhibitor domain superfamily", "go_ids": [], "go_terms": [], "name": "CDI_dom_sf", "pathway_ids": ["R-HSA-69563", "R-HSA-9607240", "R-HSA-187577", "R-MMU-187577", "R-HSA-5625900", "R-MMU-9607240", "R-MMU-198323", "R-HSA-8951664", "R-MMU-8852276", "R-HSA-69202", "R-MMU-8849470", "R-HSA-2559582", "R-HSA-69231", "R-HSA-9617828", "R-HSA-2559586", "R-HSA-198323", "R-MMU-69202", "R-HSA-69656", "R-HSA-8849470", "R-HSA-8941855", "R-MMU-6804116", "R-HSA-9616222", "R-HSA-8878166", "R-HSA-9825892", "R-CEL-69231", "R-HSA-9661069", "R-HSA-8866911", "R-HSA-5674400", "R-MMU-2559586", "R-HSA-8852276", "R-MMU-2559582", "R-HSA-9755511", "R-HSA-6804116", "R-HSA-69895", "R-HSA-6785807", "R-HSA-9634638", "R-HSA-9703465", "R-MMU-69563", "R-MMU-69656", "R-MMU-9616222", "R-MMU-9634638", "R-HSA-9725370", "R-HSA-9702518", "R-MMU-69231"], "pathways": ["R-HSA-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-9607240:r:FLT3 Signaling", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-MMU-9607240:r:FLT3 Signaling", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-8951664:r:Neddylation", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-HSA-8941855:r:RUNX3 regulates CDKN1A transcription", "R-MMU-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-CEL-69231:r:Cyclin D associated events in G1", "R-HSA-9661069:r:Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-69895:r:Transcriptional activation of cell cycle inhibitor p21", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-MMU-69563:r:p53-Dependent G1 DNA Damage Response", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9702518:r:STAT5 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"Dino_Luciferase_rpt_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044903": {"description": "Luciferase, helical bundle domain superfamily", "go_ids": [], "go_terms": [], "name": "Luciferase_hlx-bundle_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044904": {"description": "3,4-dihydroxyphenylacetate 2,3-dioxygenase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "HPCD_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044905": {"description": "Resuscitation-promoting factor Rpf1, C-terminal superfamily", "go_ids": [], "go_terms": [], "name": "Rpf1_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044906": {"description": "Nitrate reductase, alpha subunit, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Nitr_red_alph_N_sf", "pathway_ids": ["PWY-6748"], "pathways": ["PWY-6748:t:nitrate reduction VII 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"R-SCE-9639288:r:Amino acids regulate mTORC1", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-XTR-77387:r:Insulin receptor recycling", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-GGA-917977:r:Transferrin endocytosis and recycling", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DRE-983712:r:Ion channel transport", "R-RNO-983712:r:Ion channel transport", "R-XTR-1222556:r:ROS and RNS production in phagocytes", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-XTR-917977:r:Transferrin endocytosis and recycling", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-DRE-1222556:r:ROS and RNS production in phagocytes", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-GGA-9639288:r:Amino acids regulate mTORC1", "R-XTR-983712:r:Ion channel transport", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-MMU-77387:r:Insulin receptor recycling", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-SCE-77387:r:Insulin receptor recycling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DRE-917977:r:Transferrin endocytosis and recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-GGA-77387:r:Insulin receptor recycling", "R-RNO-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-GGA-1222556:r:ROS and RNS production in phagocytes", "R-DRE-77387:r:Insulin receptor recycling", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-DDI-983712:r:Ion channel transport", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-BTA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Homologous_superfamily"}, "IPR044912": {"description": "Epidermal growth factor receptor, juxtamembrane domain", "go_ids": [], "go_terms": [], "name": "Egfr_JX_dom", "pathway_ids": ["R-MMU-8863795", "R-MMU-8856828", "R-MMU-6785631", "R-MMU-2179392", "R-MMU-182971", "R-MMU-180336", "R-MMU-180292", "R-MMU-8856825", "R-MMU-6811558", "R-MMU-1227986", "R-MMU-9009391", "R-MMU-1257604", "R-MMU-445144", "R-MMU-212718", "R-MMU-8847993", "R-MMU-9013507", "R-MMU-179812", "R-MMU-1963642", "R-MMU-1236394", "R-MMU-1250196", "R-MMU-5673001", "R-MMU-8857538", "R-MMU-177929"], "pathways": ["R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-182971:r:EGFR downregulation", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-MMU-180292:r:GAB1 signalosome", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-1227986:r:Signaling by ERBB2", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-445144:r:Signal transduction by L1", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-1236394:r:Signaling by ERBB4", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-177929:r:Signaling by EGFR"], "type": "Homologous_superfamily"}, "IPR044913": {"description": "P-type trefoil domain superfamily", "go_ids": [], "go_terms": [], "name": "P_trefoil_dom_sf", "pathway_ids": ["R-MMU-70221", "R-HSA-6798695", "R-HSA-189085", "R-MMU-2534343", "R-HSA-70221", "R-HSA-5357609", "R-BTA-6798695", "R-SSC-2534343", "R-BTA-2534343", "R-RNO-70221", "R-HSA-2534343", "R-HSA-5659898", "R-MMU-6798695", "R-RNO-189085", "R-MMU-189085", "R-SSC-189085", "R-HSA-9018519", "R-RNO-6798695", "R-BTA-70221"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-5357609:r:Glycogen storage disease type II (GAA)", "R-BTA-6798695:r:Neutrophil degranulation", "R-SSC-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-BTA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-5659898:r:Intestinal saccharidase deficiencies", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-SSC-189085:r:Digestion of dietary carbohydrate", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-70221:r:Glycogen breakdown (glycogenolysis)"], "type": "Homologous_superfamily"}, "IPR044914": {"description": "Endosialidase, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Endosialidase_C_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044916": {"description": "Short tail fibre protein, C-terminal superfamily", "go_ids": [], "go_terms": [], "name": "Short_tail_fibre_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044917": {"description": "DNA-directed primase/polymerase protein", "go_ids": ["GO:0003887", "GO:0042276"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase activity:F", "GO:0042276:error-prone translesion synthesis:P"], "name": "PRIMPOL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044918": {"description": "DUF3349, helical bundle", "go_ids": [], "go_terms": [], "name": "DUF3349_helical", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044919": {"description": "HP0184-like superfamily", "go_ids": [], "go_terms": [], "name": "HP0184-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044920": {"description": "tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain superfamily", "go_ids": [], "go_terms": [], "name": "MnmG_C_subdom_sf", "pathway_ids": ["R-HSA-6787450"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Homologous_superfamily"}, "IPR044922": {"description": "HvfC, N-terminal superfamily", "go_ids": [], "go_terms": [], "name": "HvfC_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044923": {"description": "PolC, middle finger subdomain superfamily", "go_ids": [], "go_terms": [], "name": "PolC_middle_finger_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044924": {"description": "HAD-superfamily hydrolase, subfamily IA, REG-2-like, capping domain superfamily", "go_ids": [], "go_terms": [], "name": "HAD-SF_hydro_IA_REG-2-like_cap", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044925": {"description": "His-Me finger superfamily", "go_ids": [], "go_terms": [], "name": "His-Me_finger_sf", "pathway_ids": ["R-HSA-140342", "R-RNO-140342", "R-HSA-114608", "R-MMU-140342", "R-MMU-196843", "R-RNO-196843", "R-HSA-199220", "R-HSA-196843", "R-MMU-114608", "R-HSA-9913635"], "pathways": ["R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-114608:r:Platelet degranulation", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR044926": {"description": "RGS, subdomain 2", "go_ids": [], "go_terms": [], "name": 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"R-DME-209360", "R-DME-418594", "R-BTA-111933", "R-SSC-416476", "R-CEL-196299", "R-HSA-8856825", "R-SSC-418594", "R-RNO-6814122", "R-HSA-6814122", "R-HSA-4411364", "R-RNO-195253", "R-MMU-418555", "R-RNO-201681", "R-MMU-416476", "R-CEL-983231", "R-DME-209155", "R-HSA-8939256", "R-MMU-9013106", "R-RNO-418597", "R-RNO-5635838", "R-RNO-416572", "R-RNO-9013149", "R-MMU-416572", "R-BTA-418594", "R-HSA-5358747", "R-RNO-196299", "R-DRE-4641262", "R-DME-4641262", "R-HSA-4641257", "R-HSA-9018519", "R-DME-209413", "R-HSA-5358749", "R-DRE-418594", "R-MMU-5635838", "R-HSA-2514859", "R-SPO-983231", "R-CFA-416482", "R-MMU-111933", "R-HSA-5467340", "R-DRE-196299", "R-BTA-416476", "R-HSA-9013149", "R-HSA-8980692", "R-CFA-9013106", "R-MMU-4641257", "R-BTA-418555", "R-HSA-5635838", "R-SSC-418597", "R-RNO-2514859", "R-HSA-5358751", "R-RNO-418555", "R-MMU-8856825", "R-GGA-418594", "R-HSA-5467348", "R-RNO-111933", "R-MMU-9013148", "R-HSA-416476", "R-MMU-983231", "R-CEL-416476", "R-CEL-6814122", "R-DME-195253", "R-DME-209214", "R-DME-5635838", "R-HSA-5339716", "R-MMU-2514859", "R-RNO-9013106", "R-DRE-2514859", "R-MMU-6814122", "R-DME-209190", "R-HSA-193648", "R-BTA-5635838", "R-RNO-8856825", "R-DME-196299", "R-CEL-418594", "R-BTA-8856825", "R-HSA-418594", "R-DME-209440", "R-MMU-9013026", "R-MMU-416482", "R-SSC-2514859", "R-SPO-418594", "R-DRE-416476", "R-CFA-193648", "R-CEL-4641257"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-DRE-418597:r:G alpha (z) signalling events", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-DME-4641257:r:Degradation of AXIN", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-HSA-8931987:r:RUNX1 regulates estrogen receptor mediated transcription", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-CFA-8980692:r:RHOA GTPase cycle", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-BTA-418597:r:G alpha (z) signalling events", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-418597:r:G alpha (z) signalling events", "R-HSA-418597:r:G alpha (z) signalling events", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-111933:r:Calmodulin induced events", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-193648:r:NRAGE 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"R-RNO-416482:r:G alpha (12/13) signalling events", "R-DME-209396:r:Phosphorylation of ARM", "R-CEL-111933:r:Calmodulin induced events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-416476:r:G alpha (q) signalling events", "R-GGA-418597:r:G alpha (z) signalling events", "R-CFA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DME-418594:r:G alpha (i) signalling events", "R-BTA-111933:r:Calmodulin induced events", "R-SSC-416476:r:G alpha (q) signalling events", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated 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"R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-DRE-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-4641257:r:Degradation of AXIN", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-DRE-418594:r:G alpha (i) signalling events", "R-MMU-5635838:r:Activation of SMO", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SPO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CFA-416482:r:G alpha (12/13) signalling events", "R-MMU-111933:r:Calmodulin induced events", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-DRE-196299:r:Beta-catenin phosphorylation cascade", "R-BTA-416476:r:G alpha (q) signalling events", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-4641257:r:Degradation of AXIN", "R-BTA-418555:r:G alpha (s) signalling events", "R-HSA-5635838:r:Activation of SMO", "R-SSC-418597:r:G alpha (z) signalling events", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-RNO-418555:r:G alpha (s) signalling events", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-418594:r:G alpha (i) signalling events", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-RNO-111933:r:Calmodulin induced events", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-416476:r:G alpha (q) signalling events", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-209214:r:Phosphorylation of SMO", "R-DME-5635838:r:Activation of SMO", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-9013106:r:RHOC GTPase cycle", "R-DRE-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-209190:r:Phosphorylation of CI", "R-HSA-193648:r:NRAGE signals death through JNK", "R-BTA-5635838:r:Activation of SMO", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-CEL-418594:r:G alpha (i) signalling events", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-418594:r:G alpha (i) signalling events", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-SSC-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SPO-418594:r:G alpha (i) signalling events", "R-DRE-416476:r:G alpha (q) signalling events", "R-CFA-193648:r:NRAGE signals death through JNK", "R-CEL-4641257:r:Degradation of AXIN"], "type": "Homologous_superfamily"}, "IPR044927": {"description": "Type VII secretion system protein EssD-like", "go_ids": [], "go_terms": [], "name": "Endonuclea_NS_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR044928": {"description": "Secreted effector protein SifA, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "SifA_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044929": {"description": "DNA/RNA non-specific endonuclease superfamily", "go_ids": [], "go_terms": [], "name": "DNA/RNA_non-sp_Endonuclease_sf", "pathway_ids": ["R-RNO-196843", "R-HSA-114608", "R-HSA-199220", "R-MMU-196843", "R-HSA-196843", "R-HSA-9913635", "R-MMU-114608", "R-CEL-196843"], "pathways": ["R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-114608:r:Platelet degranulation", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-MMU-114608:r:Platelet degranulation", "R-CEL-196843:r:Vitamin B2 (riboflavin) metabolism"], "type": "Homologous_superfamily"}, "IPR044930": {"description": "Homing endonuclease, His-Me finger superfamily", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "Homing_endonuclease_His-Me", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044932": {"description": "Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment superfamily", "go_ids": [], "go_terms": [], "name": "PfEMP1_ATS_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044933": {"description": "Diaphanous, GTPase-binding domain superfamily", "go_ids": [], "go_terms": [], "name": "DIA_GBD_sf", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013405", "R-MMU-6785631", "R-HSA-6798695", "R-RNO-6798695", "R-HSA-9013409", "R-RNO-6785631", "R-MMU-9013106", "R-RNO-9035034", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-HSA-9013106", "R-MMU-9013404", "R-HSA-9013423", "R-DME-9035034", "R-HSA-9035034", "R-DME-9013406", "R-HSA-9013148", "R-RNO-9013404", "R-RNO-9013406", "R-RNO-9013106", "R-RNO-9013408", "R-DME-5663220", "R-HSA-9013408", "R-MMU-9035034", "R-DME-9013149", "R-DME-8980692", "R-DME-6798695", "R-DME-6785631", "R-HSA-6785631", "R-RNO-5663220", "R-RNO-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-9854909", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9013026", "R-MMU-6798695", "R-HSA-5663220", "R-HSA-9013406", "R-MMU-9013149", "R-DME-9013423", "R-MMU-5663220"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Homologous_superfamily"}, "IPR044934": {"description": "Peptidase C10, streptopain superfmaily", "go_ids": [], "go_terms": [], "name": "Streptopain_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044935": {"description": "Domain of unknown function DUF5086 superfamily", "go_ids": [], "go_terms": [], "name": "DUF5086_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044936": {"description": "Alphavirus nsP2 protease domain superfamily", "go_ids": [], "go_terms": [], "name": "Alphavirus_nsp2pro_sf", "pathway_ids": ["PWY-7045", "PWY-5381", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-7706", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-5316", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-7529", "PWY-8076", "PWY-5479", "PWY-6322", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-7342", "PWY-7904", "PWY-6736", "PWY-6998", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-7888", "PWY-5773", "PWY-7155", "PWY-7719", "PWY-7076", "PWY-7737", "PWY-8106", "PWY-6682", "PWY-8104", "PWY-7419", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-6545", "PWY-8379", "PWY-6749", "PWY-7668", "PWY-8179", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-7769", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-7127", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6626", "PWY-6286", "PWY-6581", "PWY-4202", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-7184", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-2681", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-7185", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7210", "PWY-7729", "PWY-7198", "PWY-7375", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-8117", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-7375:t:mRNA capping I", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Homologous_superfamily"}, "IPR044937": {"description": "Mu1 membrane penetration protein, domain III", "go_ids": [], "go_terms": [], "name": "Mu1_membr_pen_domIII", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044938": {"description": "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "EDC4_C_sf", "pathway_ids": ["R-RNO-430039", "R-MMU-430039", "R-DME-430039", "R-DRE-430039", "R-HSA-430039"], "pathways": ["R-RNO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DME-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Homologous_superfamily"}, "IPR044939": {"description": "Ethanolamine ammonia-lyase heavy chain, domain 2", "go_ids": [], "go_terms": [], "name": "EutB_dom_2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044940": {"description": "Nitric oxide synthase, domain 2 superfamily", "go_ids": [], "go_terms": [], "name": "NOS_dom_2", "pathway_ids": ["PWY-4983", "R-MMU-1222556", "R-SSC-9033241", "R-MMU-9856530", "R-HSA-1474151", "R-HSA-392154", "R-DME-1222556", "R-RNO-9009391", "R-MMU-203615", "R-MMU-9009391", "R-MMU-203641", "R-RNO-1222556", "R-RNO-392154", "R-RNO-5218920", "R-HSA-203615", "R-RNO-9033241", "R-HSA-5218920", "R-HSA-1222556", "R-RNO-1474151", "R-MMU-392154", "R-DME-9009391", "R-HSA-5578775", "R-RNO-203641", "R-HSA-203641", "R-RNO-203754", "R-SSC-1222556", "R-HSA-9636249", "R-MMU-5218920", "R-DME-392154", "R-DME-5578775", "R-RNO-5578775", "R-DME-9033241", "R-MMU-5578775", "R-MMU-9033241", "R-HSA-6785807", "R-SSC-392154", "R-DME-203615", "R-MMU-1474151", "R-RNO-203615", "R-DME-5218920", "R-RNO-9856530", "R-HSA-203754", "R-HSA-9009391", "R-MMU-203754", "R-DME-203754", "R-DME-1474151", "R-HSA-9856530", "R-HSA-9033241", "R-DME-9856530"], "pathways": ["PWY-4983:t:nitric oxide biosynthesis II (mammals)", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-9033241:r:Peroxisomal protein import", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203615:r:eNOS activation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-203615:r:eNOS activation", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-203754:r:NOSIP mediated eNOS trafficking", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-DME-9033241:r:Peroxisomal protein import", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-203615:r:eNOS activation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-DME-203754:r:NOSIP mediated eNOS trafficking", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Homologous_superfamily"}, "IPR044941": {"description": "Ethanolamine ammonia-lyase heavy chain, N-terminal domain", "go_ids": [], "go_terms": [], "name": "EutB_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044942": {"description": "Adenovirus Pll, hexon, subdomain 2", "go_ids": [], "go_terms": [], "name": "Adenovirus_Pll_hexon_sub2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR044943": {"description": "Nitric oxide synthase, domain 1 superfamily", "go_ids": [], "go_terms": [], "name": "NOS_dom_1", "pathway_ids": ["PWY-4983", "R-MMU-1222556", "R-SSC-9033241", "R-MMU-9856530", "R-HSA-1474151", "R-HSA-392154", "R-DME-1222556", "R-RNO-9009391", "R-MMU-203615", "R-MMU-9009391", "R-MMU-203641", "R-RNO-1222556", "R-RNO-392154", "R-RNO-5218920", "R-HSA-203615", "R-RNO-9033241", 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ribosomal RNA subunit accumulation protein YceD homologue 2, chloroplastic", "go_ids": [], "go_terms": [], "name": "YceD_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044986": {"description": "Kinesin-like protein KIF15/KIN-12", "go_ids": [], "go_terms": [], "name": "KIF15/KIN-12", "pathway_ids": ["R-RNO-2132295", "R-HSA-2132295", "R-RNO-6811434", "R-HSA-6811434", "R-HSA-983189", "R-RNO-983189", "R-MMU-2132295", "R-MMU-983189", "R-MMU-6811434"], "pathways": ["R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-983189:r:Kinesins", "R-RNO-983189:r:Kinesins", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983189:r:Kinesins", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR044987": {"description": "Uncharacterized mitochondrial protein AtMg00030-like", "go_ids": [], "go_terms": [], "name": "AtMg00030-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044988": {"description": "ATP synthase, F0 complex, subunit MI25, plants", "go_ids": [], "go_terms": [], "name": "MI25_plants", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044989": {"description": "Protein TILLER ANGLE CONTROL 1", "go_ids": ["GO:0001763"], "go_terms": ["GO:0001763:morphogenesis of a branching structure:P"], "name": "TAC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044991": {"description": "Tetraspani, plant", "go_ids": ["GO:0009734", "GO:0016020"], "go_terms": ["GO:0009734:auxin-activated signaling pathway:P", "GO:0016020:membrane:C"], "name": "TET_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044992": {"description": "Glutamine amidotransferase domain containing protein ChyE-like", "go_ids": [], "go_terms": [], "name": "ChyE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044993": {"description": "Beta-D-xylosidase", "go_ids": ["GO:0045493", "GO:0009044"], "go_terms": ["GO:0045493:xylan catabolic process:P", "GO:0009044:xylan 1,4-beta-xylosidase activity:F"], "name": "BXL", "pathway_ids": ["PWY-6717"], "pathways": ["PWY-6717:t:(1,4)-beta-D-xylan degradation"], "type": "Family"}, "IPR044996": {"description": "Coenzyme Q-binding protein COQ10-like", "go_ids": ["GO:0045333", "GO:0048039"], "go_terms": ["GO:0045333:cellular respiration:P", "GO:0048039:ubiquinone binding:F"], "name": "COQ10-like", "pathway_ids": ["R-RNO-611105", "R-HSA-9864848", "R-HSA-611105", "R-DME-9864848", "R-DRE-611105", "R-MMU-611105", "R-DRE-9864848", "R-MMU-9864848", "R-DME-611105"], "pathways": ["R-RNO-611105:r:Respiratory electron transport", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-DME-9864848:r:Complex IV assembly", "R-DRE-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-DRE-9864848:r:Complex IV assembly", "R-MMU-9864848:r:Complex IV assembly", "R-DME-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR044997": {"description": "F-box protein, plant", "go_ids": [], "go_terms": [], "name": "F-box_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR044998": {"description": "Timeless", "go_ids": [], "go_terms": [], "name": "Timeless", "pathway_ids": ["R-DME-432620", "R-DME-538898", "R-HSA-5693607", "R-DME-432553", "R-DME-432395", "R-RNO-5693607", "R-DME-432490", "R-DME-432501", "R-MMU-5693607"], "pathways": ["R-DME-432620:r:Dephosphorylation of PER", "R-DME-538898:r:Dephosphorylation of TIM", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-432395:r:Degradation of TIM", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DME-432490:r:Nuclear import of PER and TIM", "R-DME-432501:r:Transcription repression by PER and activation by PDP1", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Family"}, "IPR044999": {"description": "Protein CbbY-like", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "CbbY-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045000": {"description": "Tropinone reductase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "TR", "pathway_ids": ["PWY-5882", "PWY-5848", "PWY-7045", "PWY-5751", "PWY-7825", "PWY-7788", "PWY-5666", "PWY-8132", "PWY-8426", "PWY-5392", "PWY-6627", "PWY-6946", "PWY-7300", "PWY-6392", "PWY-6945", "PWY-6302", "PWY-8238", "PWY-7948", "PWY-7689", "PWY-8029", "PWY-7321", "PWY-7340", "PWY-7385", "PWY-7440", "PWY-7726", "PWY-5972", "PWY-7692", "PWY-1186", "PWY-8370", "PWY-7489", "PWY-7615", "PWY-7757", "PWY-7337", "PWY-6883", "PWY-7694", "PWY-7693", "PWY-6672", "PWY-7568", "PWY-3162", "PWY-5316", "PWY-5818", "PWY-7787", "PWY-6080", "PWY-7667", "PWY-6926", "PWY-6539", "PWY-5978", "PWY-6634", "PWY-5830", "PWY-8383", "PWY-6322", "PWY-8411", "PWY-7338", "PWY-6704", "PWY-6583", "PWY-8139", "PWY-5652", "PWY-8374", "PWY-7342", "PWY-7774", "PWY-6693", "PWY-7354", "PWY-7531", "PWY-7547", "PWY-6738", "PWY-8012", "PWY-6682", "PWY-7331", "PWY-7104", "PWY-7490", "PWY-6920", "PWY-7811", "PWY-7339", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7657", "PWY-8419", "PWY-5271", "PWY-7734", "PWY-7682", "PWY-7541", "PWY-6626", "PWY-6391", "PWY-6638", "PWY-8152", "PWY-3261", "PWY-8464", "PWY-6733", "PWY-321", "PWY-6637", "PWY-7660", "PWY-6944", "PWY-7288", "PWY-6659", "PWY-7301", "PWY-8367", "PWY-6786", "PWY-6973", "PWY-2541", "PWYG-321", "PWY-5883", "PWY-6053", "PWY-7042", "PWY-7742", "PWY-7621", "PWY-8410", "PWY-5867", "PWY-8214", "PWY-7554", "PWY-8409", "PWY-7814", "PWY-7557", "PWY-8297", "PWY-7403", "PWY-7241", "PWY-6948", "PWY-7610", "PWY-8155", "PWY-6974", "PWY-2601", "PWY-7396", "PWY-7695", "PWY-7304", "PWY-8058", "PWY-8366", "PWY-7043", "PWY-7520", "PWY-6863", "PWY-6976", "PWY-3722", "PWY-7352", "PWY-6989", "PWY-6061", "PWY-8408", "PWY-7649", "PWY-8397", "PWY-7613", "PWY-5782", "PWY-741", "PWY-7333", "PWY-5101", "PWY-7775", "PWY-1121", "PWY-7606", "PWY-7741", "PWY-7779"], "pathways": ["PWY-5882:t:epoxypseudoisoeugenol-2-methylbutanoate biosynthesis", "PWY-5848:t:cinchona alkaloids biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-5751:t:phenylethanol biosynthesis", "PWY-7825:t:juglone degradation", "PWY-7788:t:erythritol degradation II", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-5392:t:reductive TCA cycle II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-6392:t:meso-butanediol biosynthesis II", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-7692:t:bikaverin biosynthesis", "PWY-1186:t:L-homomethionine biosynthesis", "PWY-8370:t:leporin B biosynthesis", "PWY-7489:t:oryzalexin A, B, and C biosynthesis", "PWY-7615:t:pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)", "PWY-7757:t:bisphenol A degradation", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7568:t:L-galactose degradation", "PWY-3162:t:L-tryptophan degradation V (side chain pathway)", "PWY-5316:t:nicotine biosynthesis", "PWY-5818:t:validamycin biosynthesis", "PWY-7787:t:L-threitol degradation", "PWY-6080:t:4-ethylphenol degradation (anaerobic)", "PWY-7667:t:apicidin biosynthesis", "PWY-6926:t:pyrethrin I biosynthesis", "PWY-6539:t:(Z)-phenylmethanethial S-oxide biosynthesis", "PWY-5978:t:kanosamine biosynthesis I", "PWY-6634:t:3-sulfopropanediol degradation I", "PWY-5830:t:CDP-ascarylose biosynthesis", "PWY-8383:t:myxochelin A and B biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-6704:t:L-ascorbate degradation IV", "PWY-6583:t:pyruvate fermentation to butanol I", "PWY-8139:t:CDP-6-deoxy-D-gulose biosynthesis", "PWY-5652:t:2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA", "PWY-8374:t:antimycin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7774:t:propane degradation I", "PWY-6693:t:D-galactose degradation IV", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-6738:t:pinitol biosynthesis I", "PWY-8012:t:mupirocin biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7331:t:UDP-N-acetyl-beta-L-quinovosamine biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7490:t:patulin biosynthesis", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7657:t:dTDP-beta-L-digitoxose biosynthesis", "PWY-8419:t:L-canavanine degradation II", "PWY-5271:t:abscisic acid degradation to phaseic acid", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7682:t:arabidopyrone biosynthesis", "PWY-7541:t:1,2-propanediol biosynthesis from lactate (engineered)", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6391:t:meso-butanediol biosynthesis I", "PWY-6638:t:sulfolactate degradation III", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-3261:t:UDP-beta-L-rhamnose biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-6637:t:sulfolactate degradation II", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-6053:t:dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)", "PWY-7042:t:the visual cycle (insects)", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "PWY-5867:t:t-anethole biosynthesis", "PWY-8214:t:3-sulfopropanediol degradation II", "PWY-7554:t:heme d1 biosynthesis", "PWY-8409:t:cyathin biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-8297:t:6-diazo-5-oxo-L-norleucine biosynthesis", "PWY-7403:t:tetramethylpyrazine degradation", "PWY-7241:t:myo-inositol degradation II", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-8155:t:testosterone degradation (anaerobic)", "PWY-6974:t:dTDP-beta-L-olivose biosynthesis", "PWY-2601:t:isethionate degradation", "PWY-7396:t:butanol and isobutanol biosynthesis (engineered)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7304:t:3-amino-4,7-dihydroxy-coumarin biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8366:t:septacidin biosynthesis", "PWY-7043:t:11-cis-3-hydroxyretinal biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-3722:t:glycine betaine biosynthesis II (Gram-positive bacteria)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6989:t:(S)-camphor degradation", "PWY-6061:t:bile acid biosynthesis, neutral pathway", "PWY-8408:t:erinacine biosynthesis", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWY-5782:t:2-keto-L-gulonate biosynthesis", "PWY-741:t:p-cymene degradation to p-cumate", "PWY-7333:t:UDP-N-acetyl-alpha-D-fucosamine biosynthesis", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-7775:t:propane degradation II", "PWY-1121:t:suberin monomers biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation"], "type": "Family"}, "IPR045001": {"description": "Developmentally regulated GTP-binding protein", "go_ids": ["GO:0003924", "GO:0005525"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005525:GTP binding:F"], "name": "DRG", "pathway_ids": ["R-DME-9629569", "R-MMU-9629569", "R-BTA-9629569", "R-DDI-9629569", "R-HSA-9629569"], "pathways": ["R-DME-9629569:r:Protein hydroxylation", "R-MMU-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-DDI-9629569:r:Protein hydroxylation", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Family"}, "IPR045002": {"description": "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like", "go_ids": ["GO:0016853"], "go_terms": ["GO:0016853:isomerase activity:F"], "name": "Ech1-like", "pathway_ids": ["PWY-6837", "PWY-7307", "R-DDI-9837999", "R-RNO-9033241", "R-HSA-9837999", "R-MMU-9837999", "R-MMU-9033241", "R-RNO-9837999", "R-DDI-9033241", "R-HSA-9033241"], "pathways": ["PWY-6837:t:fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)", "PWY-7307:t:oleate beta-oxidation (reductase-dependent, yeast)", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR045003": {"description": "Fasciclin-like arabinogalactan protein, group A", "go_ids": [], "go_terms": [], "name": "FLA_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045004": {"description": "Enoyl-CoA hydratase/isomerase domain", "go_ids": [], "go_terms": [], "name": "ECH_dom", "pathway_ids": ["PWY-6373", "PWY-3941", "PWY-7574", "R-DDI-70895", "R-DRE-70895", "R-HSA-70895", "R-SPO-70895", "R-HSA-9916722", "R-MMU-70895", "R-SCE-70895", "R-RNO-70895"], "pathways": ["PWY-6373:t:acrylate degradation I", "PWY-3941:t:beta-alanine biosynthesis II", "PWY-7574:t:propanoyl-CoA degradation II", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-DRE-70895:r:Branched-chain amino acid catabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-SPO-70895:r:Branched-chain amino acid catabolism", "R-HSA-9916722:r:3-hydroxyisobutyryl-CoA hydrolase deficiency", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-SCE-70895:r:Branched-chain amino acid catabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Domain"}, "IPR045005": {"description": "BTB/POZ and MATH domain-containing protein 1-6", "go_ids": ["GO:0016567"], "go_terms": ["GO:0016567:protein ubiquitination:P"], "name": "BPM1-6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045006": {"description": "Magnesium-chelatase subunit ChlI-like", "go_ids": [], "go_terms": [], "name": "CHLI-like", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Family"}, "IPR045007": {"description": "LAS seventeen-binding protein 5", "go_ids": ["GO:0007015", "GO:0006897"], "go_terms": ["GO:0007015:actin filament organization:P", "GO:0006897:endocytosis:P"], "name": "LSB5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045008": {"description": "Acyl-coenzyme A oxidase 4-like", "go_ids": ["GO:0003995", "GO:0006635"], "go_terms": ["GO:0003995:acyl-CoA dehydrogenase activity:F", "GO:0006635:fatty acid beta-oxidation:P"], "name": "ACX4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045009": {"description": "CASP-like protein 5", "go_ids": [], "go_terms": [], "name": "CASPL-5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045010": {"description": "Medium-chain dehydrogenase/reductase", "go_ids": ["GO:0016628"], "go_terms": ["GO:0016628:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor:F"], "name": "MDR_fam", "pathway_ids": ["R-HSA-2162123", "R-HSA-2142700", "R-HSA-2142691"], "pathways": ["R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "type": "Family"}, "IPR045011": {"description": "Arogenate dehydrogenase 1/2", "go_ids": ["GO:0033730", "GO:0006571"], "go_terms": ["GO:0033730:arogenate dehydrogenase (NADP+) activity:F", "GO:0006571:L-tyrosine biosynthetic process:P"], "name": "TYRAAT1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045012": {"description": "Protein NLP", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "NLP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045014": {"description": "Transmembrane protein 41A/B", "go_ids": [], "go_terms": [], "name": "TM41A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045015": {"description": "C-terminal binding protein AN-like", "go_ids": ["GO:0000226"], "go_terms": ["GO:0000226:microtubule cytoskeleton organization:P"], "name": "AN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045016": {"description": "Na(+)/H(+) antiporter NhaD-like", "go_ids": ["GO:0015297", "GO:0006814"], "go_terms": ["GO:0015297:antiporter activity:F", "GO:0006814:sodium ion transport:P"], "name": "NhaD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045017": {"description": "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]", "go_ids": ["GO:0008670", "GO:0009062"], "go_terms": ["GO:0008670:2,4-dienoyl-CoA reductase (NADPH) activity:F", "GO:0009062:fatty acid catabolic process:P"], "name": "DECR2-like", "pathway_ids": ["PWY-5138", "PWY-6837", "PWY-7307", "PWY-7338", "PWY-7337", "R-RNO-9033241", "R-DRE-390247", "R-HSA-390247", "R-MMU-390247", "R-SCE-9033241", "R-SCE-390247", "R-MMU-9033241", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["PWY-5138:t:fatty acid beta-oxidation IV (unsaturated, even number)", "PWY-6837:t:fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)", "PWY-7307:t:oleate beta-oxidation (reductase-dependent, yeast)", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "R-RNO-9033241:r:Peroxisomal protein import", "R-DRE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-SCE-9033241:r:Peroxisomal protein import", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Family"}, "IPR045018": {"description": "Azaguanine-like transporters", "go_ids": ["GO:0015205"], "go_terms": ["GO:0015205:nucleobase transmembrane transporter activity:F"], "name": "Azg-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045019": {"description": "Beta-carotene hydroxylase-like", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "BETA-OHASE-like", "pathway_ids": ["PWY-5288", "PWY-7947"], "pathways": ["PWY-5288:t:astaxanthin biosynthesis (bacteria, fungi, algae)", "PWY-7947:t:flexixanthin biosynthesis"], "type": "Family"}, "IPR045021": {"description": "Protein PSK SIMULATOR", "go_ids": ["GO:0045927"], "go_terms": ["GO:0045927:positive regulation of growth:P"], "name": "PSI1/2/3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045023": {"description": "Acyl-[acyl-carrier-protein] hydrolase FATA/B", "go_ids": ["GO:0016297", "GO:0006633"], "go_terms": ["GO:0016297:fatty acyl-[ACP] hydrolase activity:F", "GO:0006633:fatty acid biosynthetic process:P"], "name": "FATA/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045024": {"description": "Alternative NADH dehydrogenase", "go_ids": ["GO:0003954"], "go_terms": ["GO:0003954:NADH dehydrogenase 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protein import", "R-SCE-389599:r:Alpha-oxidation of phytanate", "R-MMU-9033241:r:Peroxisomal protein import", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-389599:r:Alpha-oxidation of phytanate"], "type": "Family"}, "IPR045026": {"description": "L10-interacting MYB domain-containing protein", "go_ids": [], "go_terms": [], "name": "LIMYB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045027": {"description": "Homer family", "go_ids": ["GO:0035256"], "go_terms": ["GO:0035256:G protein-coupled glutamate receptor binding:F"], "name": "Homer", "pathway_ids": ["R-RNO-6794361", "R-BTA-6794361", "R-HSA-6794361", "R-MMU-6794361"], "pathways": ["R-RNO-6794361:r:Neurexins and neuroligins", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-6794361:r:Neurexins and neuroligins", "R-MMU-6794361:r:Neurexins and neuroligins"], "type": "Family"}, "IPR045028": {"description": "Helicase superfamily 1/2, DinG/Rad3-like", "go_ids": [], 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"R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-GGA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "type": "Family"}, "IPR045030": {"description": "LysM and putative peptidoglycan-binding domain-containing protein 1-4", "go_ids": [], "go_terms": [], "name": "LYSM1-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045031": {"description": "Dihydropteroate synthase-like", "go_ids": ["GO:0009396"], "go_terms": ["GO:0009396:folic acid-containing compound biosynthetic process:P"], "name": "DHP_synth-like", "pathway_ids": ["PWY-6614"], "pathways": ["PWY-6614:t:tetrahydrofolate biosynthesis I"], "type": "Family"}, "IPR045032": {"description": "Pectin lyase family", "go_ids": ["GO:0030570"], "go_terms": ["GO:0030570:pectate lyase activity:F"], "name": "PEL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045033": {"description": "Protein PIN-LIKES 1/3/4/5/7", "go_ids": ["GO:0080162"], "go_terms": ["GO:0080162:endoplasmic reticulum to cytosol auxin transport:P"], "name": "PILS1/3/4/5/7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045034": {"description": "Probable diacyglycerol O-acyltransferase/WSD1-like", "go_ids": ["GO:0045017", "GO:0016747"], "go_terms": ["GO:0045017:glycerolipid biosynthetic process:P", "GO:0016747:acyltransferase activity, transferring groups other than amino-acyl groups:F"], "name": "Tgs/WSD1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045035": {"description": "Metal-nicotianamine transporter YSL-like", "go_ids": ["GO:0035673"], "go_terms": ["GO:0035673:oligopeptide transmembrane transporter activity:F"], "name": "YSL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045036": {"description": "Spartin-like", "go_ids": [], "go_terms": [], "name": "Spartin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045038": {"description": "Protein AIG2-like", "go_ids": [], "go_terms": [], "name": "AIG2-like", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis"], "type": "Family"}, "IPR045039": {"description": "Acetyltransferase NSI-like", "go_ids": ["GO:0008080"], "go_terms": ["GO:0008080:N-acetyltransferase activity:F"], "name": "NSI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045040": {"description": "PORR family", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "PORR_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045042": {"description": "Mechanosensitive ion channel protein YnaI-like", "go_ids": [], "go_terms": [], "name": "YnaI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045043": {"description": "Late embryogenesis abundant protein Lea14-like", "go_ids": [], "go_terms": [], "name": "Lea14-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045046": {"description": "Vacuolar protein sorting-associated protein 9-like", "go_ids": ["GO:0005085", "GO:0016192"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0016192:vesicle-mediated transport:P"], "name": "Vps9-like", "pathway_ids": ["R-BTA-8856828", "R-MMU-8856828", "R-CEL-8856828", "R-MMU-8876198", "R-CEL-8876198", "R-HSA-8854214", "R-DME-8876198", "R-HSA-8856828", "R-DME-8856828", "R-RNO-8876198", "R-BTA-8876198", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198"], "pathways": ["R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8854214:r:TBC/RABGAPs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR045047": {"description": "N-acetyltransferase Ard1-like", "go_ids": ["GO:0006474", "GO:0031415", "GO:0004596"], "go_terms": ["GO:0006474:N-terminal protein amino acid acetylation:P", "GO:0031415:NatA complex:C", "GO:0004596:protein-N-terminal amino-acid acetyltransferase activity:F"], "name": "Ard1-like", "pathway_ids": ["PWY-7800"], "pathways": ["PWY-7800:t:Ac/N-end rule pathway"], "type": "Family"}, "IPR045048": {"description": "F-box only protein 31/39", "go_ids": [], "go_terms": [], "name": "FBXO31/39", "pathway_ids": ["R-MMU-8951664", "R-HSA-983168", "R-RNO-983168", "R-XTR-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-XTR-983168", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR045049": {"description": "Choline-phosphate cytidylyltransferase Pcy1-like", "go_ids": ["GO:0004105", "GO:0006657"], "go_terms": ["GO:0004105:choline-phosphate cytidylyltransferase activity:F", "GO:0006657:CDP-choline pathway:P"], "name": "Pcy1-like", "pathway_ids": ["PWY-7782", "PWY-7818", "PWY-3561", "PWY-7886", "R-CEL-1483191", "R-SCE-1483191", "R-HSA-1483191", "R-RNO-1483191", "R-SPO-1483191", "R-MMU-1483191"], "pathways": ["PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-3561:t:choline biosynthesis III", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "R-CEL-1483191:r:Synthesis of PC", "R-SCE-1483191:r:Synthesis of PC", "R-HSA-1483191:r:Synthesis of PC", "R-RNO-1483191:r:Synthesis of PC", "R-SPO-1483191:r:Synthesis of PC", "R-MMU-1483191:r:Synthesis of PC"], "type": "Family"}, "IPR045050": {"description": "Synaptotagmin, plant", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "Synaptotagmin_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045051": {"description": "Subtilisin-like protease", "go_ids": [], "go_terms": [], "name": "SBT", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR045052": {"description": "Copine", "go_ids": ["GO:0005544"], "go_terms": ["GO:0005544:calcium-dependent phospholipid binding:F"], "name": "Copine", "pathway_ids": ["R-HSA-6798695", "R-MMU-1483206", "R-DDI-6798695", "R-HSA-9013405", "R-HSA-9013409", "R-MMU-9013406", "R-HSA-9013148", "R-BTA-1483206", "R-DDI-1483206", "R-MMU-6798695", "R-BTA-6798695", "R-HSA-1483206", "R-HSA-9013406", "R-RNO-1483206", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-1483206:r:Glycerophospholipid biosynthesis", "R-DDI-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-1483206:r:Glycerophospholipid biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR045053": {"description": "Mannan endo-1,4-beta-mannosidase-like", "go_ids": ["GO:0004553"], "go_terms": ["GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "MAN-like", "pathway_ids": ["PWY-7456"], "pathways": ["PWY-7456:t:beta-(1,4)-mannan degradation"], "type": "Family"}, "IPR045054": {"description": "Prolyl 4-hydroxylase", "go_ids": [], "go_terms": [], "name": "P4HA-like", "pathway_ids": ["PWY-7894", "R-HSA-1650814", "R-HSA-9918432"], "pathways": ["PWY-7894:t:procollagen hydroxylation and glycosylation", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Family"}, "IPR045055": {"description": "DNA2/NAM7-like helicase", "go_ids": [], "go_terms": [], "name": "DNA2/NAM7-like", "pathway_ids": ["R-DDI-975956", "R-BTA-69473", "R-RNO-174437", "R-BTA-5685938", "R-HSA-6781827", "R-CEL-975957", "R-MMU-6782135", "R-MMU-6804756", "R-BTA-174437", "R-SPO-975957", "R-MMU-5693616", "R-MMU-5685938", "R-HSA-6781823", "R-MMU-69473", "R-HSA-975956", "R-RNO-69166", "R-CEL-975956", "R-MMU-6781823", "R-SCE-975957", "R-BTA-6804756", "R-BTA-69166", "R-RNO-5685938", "R-BTA-5693616", "R-MMU-174437", "R-HSA-6782210", "R-RNO-6804756", "R-BTA-5693579", "R-BTA-5693607", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-9918481", "R-SPO-69166", "R-MMU-5693607", "R-MMU-975956", "R-SPO-975956", "R-DRE-975956", "R-DME-975956", "R-RNO-5693579", "R-BTA-5693568", "R-SCE-975956", "R-MMU-72163", "R-MMU-975957", "R-RNO-5693607", "R-HSA-6782135", "R-DRE-975957", "R-MMU-5685942", "R-RNO-69473", "R-RNO-5685942", "R-HSA-72163", "R-HSA-975957", "R-SPO-6782210", "R-MMU-69166", "R-RNO-5693568", "R-BTA-5685942", "R-MMU-6782210", "R-RNO-5693616", "R-SPO-6782135", "R-DDI-975957", "R-SPO-72163", "R-DME-975957"], "pathways": ["R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Family"}, "IPR045056": {"description": "Nucleolar protein Nop56/Nop58", "go_ids": ["GO:0032040", "GO:0030515", "GO:0031428"], "go_terms": ["GO:0032040:small-subunit processome:C", "GO:0030515:snoRNA binding:F", "GO:0031428:box C/D methylation guide snoRNP complex:C"], "name": "Nop56/Nop58", "pathway_ids": ["R-MMU-6791226", "R-SPO-4570464", "R-SCE-4570464", "R-SCE-6791226", "R-HSA-390471", "R-HSA-6791226", "R-RNO-4570464", "R-DDI-6791226", "R-DDI-4570464", "R-MMU-4570464", "R-HSA-4570464", "R-CEL-6791226", "R-SPO-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-SCE-4570464:r:SUMOylation of RNA binding proteins", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR045057": {"description": "Gcn5-related N-acetyltransferase", "go_ids": [], "go_terms": [], "name": "Gcn5-rel_NAT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045058": {"description": "GTPase GIMA/IAN/Toc", "go_ids": [], "go_terms": [], "name": "GIMA/IAN/Toc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045059": {"description": "Large ribosomal subunit protein uL29, eukaryota", "go_ids": ["GO:0000463", "GO:0022625"], "go_terms": ["GO:0000463:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA):P", "GO:0022625:cytosolic large ribosomal subunit:C"], "name": "Ribosomal_uL29_euk", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-DRE-9954709", "R-RNO-1799339", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-BTA-156827", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-BTA-6791226", "R-DRE-9954714", "R-SCE-975956", "R-CEL-1799339", "R-SSC-9954714", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-SSC-1799339", "R-DRE-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-DDI-156827", "R-RNO-9954709", "R-SSC-72689", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DRE-975956", "R-BTA-9954716", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-HSA-156902", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-SSC-6791226", "R-BTA-9954709", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SSC-9954716", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SSC-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SSC-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR045060": {"description": "Phenylalanine-tRNA ligase, class IIc, beta subunit", "go_ids": ["GO:0004826", "GO:0006432"], "go_terms": ["GO:0004826:phenylalanine-tRNA ligase activity:F", "GO:0006432:phenylalanyl-tRNA aminoacylation:P"], "name": "Phe-tRNA-ligase_IIc_bsu", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Family"}, "IPR045061": {"description": "Tubulin-like protein FtsZ/CetZ", "go_ids": ["GO:0003924", "GO:0005525"], "go_terms": ["GO:0003924:GTPase activity:F", "GO:0005525:GTP binding:F"], "name": "FtsZ/CetZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045062": {"description": "Cytochrome c-type biogenesis protein CcsA/CcmC", "go_ids": ["GO:0020037", "GO:0017004"], "go_terms": ["GO:0020037:heme binding:F", "GO:0017004:cytochrome complex assembly:P"], "name": "Cyt_c_biogenesis_CcsA/CcmC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045063": {"description": "Dynamin, N-terminal", "go_ids": [], "go_terms": [], "name": "Dynamin_N", "pathway_ids": ["R-CEL-983231", "R-MMU-8856828", "R-DDI-169911", "R-DME-190873", "R-BTA-196025", "R-HSA-8856828", "R-HSA-166016", "R-CEL-432722", "R-HSA-9766229", "R-MMU-5205685", "R-BTA-190873", "R-BTA-75153", "R-RNO-196025", "R-SSC-1169408", "R-RNO-983231", "R-DME-3928665", "R-HSA-5205685", "R-HSA-203641", "R-RNO-432722", "R-SPO-169911", "R-MMU-9013419", "R-MMU-196025", "R-CEL-9013419", "R-DME-437239", "R-RNO-432720", "R-MMU-166016", "R-RNO-5205685", "R-HSA-432720", "R-DME-196025", "R-HSA-983231", "R-HSA-437239", "R-BTA-166016", "R-CFA-1169408", "R-HSA-909733", "R-SPO-190873", "R-SCE-196025", "R-HSA-9031628", "R-BTA-1169408", "R-SPO-196025", "R-MMU-9766229", "R-DRE-169911", "R-HSA-2132295", "R-SCE-169911", "R-DME-432720", "R-HSA-190873", "R-CEL-432720", "R-RNO-1169408", "R-MMU-432722", "R-CEL-190873", "R-CEL-437239", "R-RNO-9013419", "R-CEL-5205685", "R-MMU-203641", "R-HSA-1169408", "R-MMU-169911", "R-RNO-169911", "R-MMU-983231", "R-RNO-75153", "R-BTA-983231", "R-MMU-190873", "R-RNO-190873", "R-MMU-2132295", "R-HSA-169911", "R-DME-983231", "R-DME-8856828", "R-BTA-437239", "R-RNO-8856828", "R-HSA-9837999", "R-RNO-203641", "R-MMU-432720", "R-HSA-75153", "R-HSA-432722", "R-BTA-2132295", "R-DRE-75153", "R-HSA-196025", "R-BTA-8856828", "R-SCE-75153", "R-CEL-8856828", "R-RNO-2132295", "R-MMU-437239", "R-RNO-437239", "R-CEL-196025", "R-DME-9013419", "R-DME-432722", "R-DDI-75153", "R-MMU-1169408", "R-MMU-75153", "R-CEL-3928665", "R-HSA-177504", "R-CEL-75153", "R-CEL-1169408", "R-DME-5205685", "R-HSA-3928665", "R-RNO-9766229", "R-PFA-75153", "R-HSA-9013419", "R-RNO-166016", "R-SPO-75153", "R-SCE-190873"], "pathways": ["R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-DDI-169911:r:Regulation of Apoptosis", "R-DME-190873:r:Gap junction degradation", "R-BTA-196025:r:Formation of annular gap junctions", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9766229:r:Degradation of CDH1", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-190873:r:Gap junction degradation", "R-BTA-75153:r:Apoptotic execution phase", "R-RNO-196025:r:Formation of annular gap junctions", "R-SSC-1169408:r:ISG15 antiviral mechanism", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-169911:r:Regulation of 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"R-DRE-169911:r:Regulation of Apoptosis", "R-HSA-2132295:r:MHC class II antigen presentation", "R-SCE-169911:r:Regulation of Apoptosis", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-190873:r:Gap junction degradation", "R-CEL-437239:r:Recycling pathway of L1", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-169911:r:Regulation of Apoptosis", "R-RNO-169911:r:Regulation of Apoptosis", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-75153:r:Apoptotic execution phase", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-190873:r:Gap junction degradation", "R-RNO-190873:r:Gap junction degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-169911:r:Regulation of Apoptosis", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-75153:r:Apoptotic execution phase", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-DRE-75153:r:Apoptotic execution phase", "R-HSA-196025:r:Formation of annular gap junctions", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-SCE-75153:r:Apoptotic execution phase", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-CEL-196025:r:Formation of annular gap junctions", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-75153:r:Apoptotic execution phase", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-75153:r:Apoptotic execution phase", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-CEL-75153:r:Apoptotic execution phase", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-9766229:r:Degradation of CDH1", "R-PFA-75153:r:Apoptotic execution phase", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-SPO-75153:r:Apoptotic execution phase", "R-SCE-190873:r:Gap junction degradation"], "type": "Domain"}, "IPR045064": {"description": "Reticulon-like", "go_ids": ["GO:0009617"], "go_terms": ["GO:0009617:response to bacterium:P"], "name": "Reticulon-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045065": {"description": "Exportin-1/5", "go_ids": ["GO:0005049", "GO:0006611"], "go_terms": ["GO:0005049:nuclear export signal receptor activity:F", "GO:0006611:protein export from nucleus:P"], "name": "XPO1/5", "pathway_ids": ["R-MMU-9856649", "R-DME-69273", "R-DME-9634638", "R-HSA-2467813", "R-HSA-3769402", "R-SPO-5687128", "R-DME-9707616", "R-RNO-2500257", "R-MMU-2467813", "R-SCE-9856649", "R-HSA-69273", "R-RNO-450520", "R-RNO-5687128", "R-MMU-68877", "R-RNO-9634638", "R-HSA-168333", "R-HSA-9828806", "R-HSA-203927", "R-HSA-68877", "R-MMU-9707616", "R-HSA-165054", "R-RNO-9707616", "R-RNO-141444", "R-MMU-9648025", "R-MMU-2500257", "R-MMU-3769402", "R-RNO-68877", "R-HSA-2500257", "R-DDI-5687128", "R-MMU-141444", "R-RNO-9856649", "R-HSA-9918432", "R-DME-9856649", "R-HSA-141444", "R-HSA-450520", "R-HSA-9707616", "R-MMU-450520", "R-HSA-9648025", "R-DME-450520", "R-HSA-9634638", "R-RNO-5663220", "R-RNO-69273", "R-DME-3769402", "R-HSA-5687128", "R-HSA-9856649", "R-HSA-5663220", "R-MMU-9634638", "R-MMU-5687128", "R-SCE-5687128", "R-MMU-69273", "R-HSA-2173788", "R-RNO-9648025", "R-RNO-2467813", "R-RNO-3769402", "R-MMU-5663220", "R-HSA-9768919"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SPO-5687128:r:MAPK6/MAPK4 signaling", "R-DME-9707616:r:Heme signaling", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-9707616:r:Heme signaling", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-RNO-9707616:r:Heme signaling", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9918432:r:Maturation of DENV proteins", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9707616:r:Heme signaling", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Family"}, "IPR045068": {"description": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1-3", "go_ids": [], "go_terms": [], "name": "BACURD1-3", "pathway_ids": ["R-DRE-9696264", "R-HSA-9696270", "R-RNO-9696270", "R-XTR-9696264", "R-RNO-9696264", "R-GGA-9696270", "R-MMU-9696264", "R-MMU-9696270", "R-DRE-9696270", "R-CEL-983168", "R-CEL-8951664", "R-HSA-9696264", "R-GGA-9696264"], "pathways": ["R-DRE-9696264:r:RND3 GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-XTR-9696264:r:RND3 GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-GGA-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-DRE-9696270:r:RND2 GTPase cycle", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-GGA-9696264:r:RND3 GTPase cycle"], "type": "Family"}, "IPR045071": {"description": "KH domain-containing BBP-like", "go_ids": [], "go_terms": [], "name": "BBP-like", "pathway_ids": ["R-HSA-72163", "R-MMU-8849468", "R-RNO-8849468", "R-HSA-6802952", "R-MMU-72163", "R-XTR-8849468", "R-DRE-8849468", "R-HSA-8849468"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-XTR-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-DRE-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing"], "type": "Family"}, "IPR045072": {"description": "MKRN-like", "go_ids": ["GO:0000209", "GO:0061630"], "go_terms": ["GO:0000209:protein polyubiquitination:P", "GO:0061630:ubiquitin protein ligase activity:F"], "name": "MKRN-like", "pathway_ids": ["PWY-7511", "R-SCE-198323", "R-SCE-8948751", "R-DRE-8948751", "R-MMU-198323", "R-MMU-983168", "R-SPO-983168", "R-HSA-8948751", "R-CEL-8948751", "R-MMU-8948751", "R-SPO-8948751", "R-SCE-983168", "R-CEL-198323", "R-HSA-983168", "R-CEL-983168", "R-DRE-198323", "R-SPO-198323", "R-HSA-198323", "R-DRE-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SCE-198323:r:AKT phosphorylates targets in the cytosol", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-SPO-8948751:r:Regulation of PTEN stability and activity", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-SPO-198323:r:AKT phosphorylates targets in the cytosol", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR045073": {"description": "Glutathione S-transferase Omega/Tau-like", "go_ids": [], "go_terms": [], "name": "Omega/Tau-like", "pathway_ids": ["PWY-6842", "PWY-7533", "PWY-7112", "PWY-4061", "R-HSA-156581", "R-RNO-196836", "R-HSA-8950505", "R-RNO-156590", "R-HSA-156590", "R-HSA-196836", "R-RNO-156581"], "pathways": ["PWY-6842:t:glutathione-mediated detoxification II", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7112:t:4-hydroxy-2-nonenal detoxification", "PWY-4061:t:glutathione-mediated detoxification I", "R-HSA-156581:r:Methylation", "R-RNO-196836:r:Vitamin C (ascorbate) metabolism", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-156590:r:Glutathione conjugation", "R-HSA-156590:r:Glutathione conjugation", "R-HSA-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-156581:r:Methylation"], "type": "Family"}, "IPR045075": {"description": "Pre-mRNA-splicing factor Syf1-like", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "Syf1-like", "pathway_ids": ["R-DDI-6782135", "R-RNO-6781823", "R-HSA-6781827", "R-BTA-72165", "R-MMU-6782135", "R-DME-6781823", "R-MMU-72163", "R-RNO-6782135", "R-DDI-6781823", "R-DME-72163", "R-RNO-72163", "R-DDI-6782210", "R-HSA-6782135", "R-DDI-72163", "R-HSA-6781823", "R-RNO-6782210", "R-DRE-72163", "R-HSA-72163", "R-MMU-6781823", "R-MMU-72165", "R-RNO-72165", "R-SPO-6782210", "R-HSA-6782210", "R-HSA-72165", "R-DME-6782210", "R-MMU-6782210", "R-SPO-6782135", "R-SCE-6782210", "R-SPO-72163", "R-DME-6782135", "R-HSA-9918481", "R-SCE-6782135", "R-BTA-72163"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SCE-6782135:r:Dual incision in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR045076": {"description": "DNA mismatch repair MutS", "go_ids": ["GO:0005524", "GO:0030983", "GO:0006298", "GO:0140664"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0030983:mismatched DNA binding:F", "GO:0006298:mismatch repair:P", "GO:0140664:ATP-dependent DNA damage sensor activity:F"], "name": "MutS", "pathway_ids": ["R-BTA-5358606", "R-RNO-5358565", "R-SPO-5358565", "R-HSA-5632927", "R-HSA-5358606", "R-DDI-5358565", "R-SCE-5358606", "R-HSA-6796648", "R-DME-5358565", "R-HSA-5632928", "R-HSA-5632968", "R-BTA-5358565", "R-SCE-5358565", "R-HSA-912446", "R-SPO-5358606", "R-HSA-5358565", "R-MMU-5358606", "R-MMU-5358565"], "pathways": ["R-BTA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632927:r:Defective Mismatch Repair Associated With MSH3", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5632928:r:Defective Mismatch Repair Associated With MSH2", "R-HSA-5632968:r:Defective Mismatch Repair Associated With MSH6", "R-BTA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-912446:r:Meiotic recombination", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "type": "Family"}, "IPR045077": {"description": "Large ribosomal subunit protein uL3, archaea/eukaryota", "go_ids": ["GO:0005840", "GO:0003735", "GO:0006412"], "go_terms": ["GO:0005840:ribosome:C", "GO:0003735:structural constituent of ribosome:F", "GO:0006412:translation:P"], "name": "L3_arc_euk", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SSC-72706", "R-RNO-975957", "R-SPO-9954709", "R-MMU-6791226", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-CEL-1799339", "R-SSC-9954714", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-SSC-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SSC-72689", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-MMU-1799339", "R-DDI-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-72689", "R-SCE-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SSC-9954716", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-DDI-9954716", "R-SCE-1799339", "R-SPO-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-SSC-9954709", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-BTA-975956", "R-BTA-9954709", "R-SSC-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) 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processing"], "type": "Family"}, "IPR045090": {"description": "Peptidase M3A/M3B", "go_ids": ["GO:0004222", "GO:0006508"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P"], "name": "Pept_M3A_M3B", "pathway_ids": ["R-DDI-983168", "R-SSC-375276", "R-RNO-375276", "R-HSA-375276", "R-MMU-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-375276"], "pathways": ["R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-375276:r:Peptide ligand-binding receptors", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-375276:r:Peptide ligand-binding 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"R-MMU-141430", "R-DDI-141430", "R-HSA-5663220", "R-HSA-179409", "R-SCE-110312", "R-MMU-5663220"], "pathways": ["R-SPO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-110312:r:Translesion synthesis by REV1", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DDI-110312:r:Translesion synthesis by REV1", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DRE-5656121:r:Translesion synthesis by POLI", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-MMU-110312:r:Translesion synthesis by REV1", "R-SPO-110312:r:Translesion synthesis by REV1", "R-DME-5656121:r:Translesion synthesis by POLI", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-XTR-110312:r:Translesion synthesis by REV1", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-68877:r:Mitotic Prometaphase", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-110312:r:Translesion synthesis by REV1", "R-MMU-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-GGA-353473:r:Translesion synthesis by Pol zeta", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-353299:r:RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-GGA-5656121:r:Translesion synthesis by POLI", "R-SCE-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-XTR-5656121:r:Translesion synthesis by POLI", "R-DRE-5655862:r:Translesion synthesis by POLK", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SPO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-110312:r:Translesion synthesis by REV1", "R-GGA-110312:r:Translesion synthesis by REV1", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SCE-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SCE-110312:r:Translesion synthesis by REV1", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR045092": {"description": "Exosome complex exonuclease Rrp6-like", "go_ids": ["GO:0000467", "GO:0000175"], "go_terms": ["GO:0000467:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA):P", "GO:0000175:3'-5'-RNA exonuclease activity:F"], "name": "Rrp6-like", "pathway_ids": ["R-MMU-9930044", "R-MMU-6791226", "R-HSA-9930044", "R-SCE-6791226", "R-HSA-6791226", "R-DME-9930044", "R-DME-6791226", "R-CEL-9930044", "R-CEL-6791226", "R-SPO-9930044", "R-RNO-9930044", "R-SPO-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-9930044:r:Nuclear RNA decay", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-9930044:r:Nuclear RNA decay", "R-RNO-9930044:r:Nuclear RNA decay", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR045093": {"description": "Cullin", "go_ids": [], "go_terms": [], "name": "Cullin", "pathway_ids": ["R-HSA-9020702", "R-HSA-9013418", "R-HSA-9604323", "R-RNO-9013422", "R-CEL-5632684", "R-HSA-8951664", "R-HSA-9010553", "R-CEL-195253", "R-MMU-9020702", "R-DDI-6782210", "R-MMU-9706019", "R-HSA-69231", "R-RNO-8863795", "R-MMU-110314", "R-CEL-110314", "R-HSA-5684264", "R-CEL-1234176", "R-HSA-8863795", "R-DDI-9929491", "R-SPO-917937", "R-XTR-9013418", "R-DME-5676590", "R-HSA-8854050", "R-MMU-5696394", "R-CEL-5696394", "R-HSA-5610783", "R-HSA-2122947", "R-CEL-69231", "R-HSA-9708530", "R-HSA-1234176", "R-RNO-4641258", "R-CEL-917937", "R-HSA-5607761", "R-HSA-9929491", "R-HSA-1170546", "R-MMU-174113", "R-DME-209461", "R-XTR-9929491", "R-RNO-9705462", "R-CEL-6782210", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-DDI-5696394", "R-RNO-8951664", "R-SPO-110314", "R-HSA-5696395", "R-HSA-5696394", "R-CEL-5696395", "R-CEL-6782135", "R-DME-69601", "R-SPO-8951664", "R-HSA-2644606", "R-MMU-9013418", "R-DDI-9013418", "R-DDI-187577", "R-HSA-9833109", "R-SCE-917937", "R-RNO-5632684", "R-HSA-5610785", "R-HSA-68949", "R-DME-983168", "R-HSA-6781827", "R-DME-202424", "R-DME-187577", "R-DDI-5696395", "R-MMU-187577", "R-SCE-8854050", "R-MMU-68949", "R-DME-2565942", "R-CEL-983168", "R-DDI-9013422", "R-CEL-8854050", "R-MMU-917937", "R-MMU-6781823", "R-DDI-9706019", "R-DDI-69601", "R-HSA-6782210", "R-MMU-9762114", "R-HSA-9762114", "R-DME-917937", "R-MMU-195253", "R-MMU-5696400", "R-MMU-202424", "R-RNO-9013418", "R-HSA-195253", "R-HSA-5610780", "R-HSA-381038", "R-DME-209360", "R-CEL-9755511", "R-DDI-917937", "R-DDI-69231", "R-RNO-9755511", "R-MMU-1169091", "R-XTR-8951664", "R-MMU-5607761", "R-DME-8854050", "R-MMU-5676590", "R-HSA-8939902", "R-HSA-9725371", "R-MMU-8939902", "R-CEL-2565942", "R-SPO-6782210", "R-HSA-5696400", "R-DME-9020702", "R-CEL-9762114", "R-CEL-8951664", "R-SPO-8854050", "R-DDI-8854050", "R-MMU-5632684", "R-HSA-9013422", "R-MMU-5607764", "R-DME-8951664", "R-HSA-9932298", "R-DME-69231", "R-CEL-187577", "R-HSA-5676590", "R-MMU-2565942", "R-DDI-8951664", "R-HSA-6781823", "R-DDI-5632684", "R-MMU-8951664", "R-MMU-5696395", "R-SPO-5696395", "R-DME-174113", "R-DME-8939902", "R-MMU-9013422", "R-MMU-9929491", "R-HSA-174113", "R-MMU-9929356", "R-MMU-5684264", "R-DME-9762114", "R-CEL-4641258", "R-DDI-5658442", "R-DDI-6781823", "R-HSA-9755511", "R-XTR-4641258", "R-HSA-4641258", "R-CEL-9929491", "R-MMU-9705462", "R-MMU-9708530", "R-CEL-6781823", "R-HSA-180585", "R-HSA-1169091", "R-HSA-5658442", "R-HSA-2644607", "R-MMU-2871837", "R-DDI-68949", "R-DME-5610785", "R-MMU-6782210", "R-DME-5607764", "R-RNO-983168", "R-DME-2871837", "R-HSA-110314", "R-MMU-69231", "R-DDI-6782135", "R-MMU-8863795", "R-MMU-5610780", "R-HSA-187577", "R-DME-1169091", "R-CEL-8863795", "R-XTR-5632684", "R-DDI-9755511", "R-MMU-6782135", "R-DME-5610780", "R-XTR-9013422", "R-CEL-8939902", "R-MMU-9755511", "R-MMU-9954709", "R-DME-195253", "R-MMU-69601", "R-HSA-2565942", "R-HSA-2871837", "R-MMU-5610785", "R-HSA-9954709", "R-DME-5607761", "R-MMU-8854050", "R-SPO-983168", "R-MMU-5658442", "R-SCE-983168", "R-HSA-5607764", "R-DME-68949", "R-MMU-1170546", "R-CEL-9954709", "R-RNO-9929491", "R-HSA-9706019", "R-HSA-2894862", "R-RNO-9706019", "R-HSA-69601", "R-HSA-9679191", "R-HSA-983168", "R-HSA-6782135", "R-HSA-5632684", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-XTR-983168", "R-SPO-5696400", "R-XTR-9755511", "R-RNO-5658442", "R-HSA-917937", "R-HSA-9705462", "R-MMU-983168", "R-SPO-6782135", "R-HSA-202424"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-69231:r:Cyclin D associated events in G1", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-917937:r:Iron uptake and transport", "R-XTR-9013418:r:RHOBTB2 GTPase cycle", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-CEL-69231:r:Cyclin D associated events in G1", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1170546:r:Prolactin receptor signaling", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-XTR-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-8951664:r:Neddylation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-SCE-917937:r:Iron uptake and transport", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-68949:r:Orc1 removal from chromatin", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-68949:r:Orc1 removal from chromatin", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-917937:r:Iron uptake and transport", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-9706019:r:RHOBTB3 ATPase cycle", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-917937:r:Iron uptake and transport", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-917937:r:Iron uptake and transport", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-XTR-8951664:r:Neddylation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-9020702:r:Interleukin-1 signaling", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-8951664:r:Neddylation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-69231:r:Cyclin D associated events in G1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5632684:r:Hedgehog 'on' state", "R-MMU-8951664:r:Neddylation", 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{"description": "SUN domain-containing Suco/Slp1-like", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "Suco/Slp1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045121": {"description": "Coenzyme A pyrophosphatase", "go_ids": ["GO:0010945"], "go_terms": ["GO:0010945:coenzyme A diphosphatase activity:F"], "name": "CoAse", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-390918", "R-SPO-9033241", "R-HSA-199220", "R-MMU-9033241", "R-HSA-9033241", "R-SCE-9033241"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-SPO-9033241:r:Peroxisomal protein import", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-SCE-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR045122": {"description": "Calcium permeable stress-gated cation channel 1-like", "go_ids": ["GO:0005227"], "go_terms": ["GO:0005227:calcium-activated cation channel activity:F"], "name": "Csc1-like", "pathway_ids": ["R-SCE-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-SPO-6798695", "R-DME-6798695"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR045123": {"description": "N6-adenosine-methyltransferase non-catalytic subunit METTL14-like", "go_ids": [], "go_terms": [], "name": "METTL14-like", "pathway_ids": ["R-XTR-72203", "R-HSA-72203", "R-DME-72203", "R-MMU-72203", "R-DRE-72203"], "pathways": ["R-XTR-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DRE-72203:r:Processing of Capped Intron-Containing Pre-mRNA"], "type": "Family"}, "IPR045124": {"description": "Protein suppressor of sable-like", "go_ids": ["GO:0003723", "GO:0045892"], "go_terms": ["GO:0003723:RNA binding:F", "GO:0045892:negative regulation of DNA-templated transcription:P"], "name": "Su(sable)-like", "pathway_ids": ["R-MMU-9930044", "R-DME-6807505", "R-HSA-9930044", "R-HSA-6807505", "R-MMU-6807505", "R-DME-9930044"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-9930044:r:Nuclear RNA decay"], "type": "Family"}, "IPR045125": {"description": "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like", "go_ids": ["GO:0003713", "GO:0060261"], "go_terms": ["GO:0003713:transcription coactivator activity:F", "GO:0060261:positive regulation of transcription initiation by RNA polymerase II:P"], "name": "Sub1/Tcp4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045126": {"description": "Trafficking protein particle complex subunit TRAPPC10/Trs130", "go_ids": ["GO:1990071", "GO:0048193"], "go_terms": ["GO:1990071:TRAPPII protein complex:C", "GO:0048193:Golgi vesicle 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"R-HSA-76042", "R-DDI-75953", "R-SPO-73776", "R-RNO-75953", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV 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"R-CEL-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Family"}, "IPR045131": {"description": "CDGSH iron-sulfur domain-containing protein 1/2", "go_ids": ["GO:0051537", "GO:0010506"], "go_terms": ["GO:0051537:2 iron, 2 sulfur cluster binding:F", "GO:0010506:regulation of autophagy:P"], "name": "CISD1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045132": {"description": "Ubiquitin conjugation factor E4", "go_ids": ["GO:0034450", "GO:0000151", "GO:0036503"], "go_terms": ["GO:0034450:ubiquitin-ubiquitin ligase activity:F", "GO:0000151:ubiquitin ligase complex:C", "GO:0036503:ERAD pathway:P"], "name": "UBE4", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-SPO-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen 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"R-MMU-5687128", "R-CEL-8856825", "R-MMU-9766229", "R-DME-5358346", "R-HSA-174154", "R-DDI-187577", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-DDI-382556", "R-MMU-187577", "R-HSA-2467813", "R-DME-202424", "R-DME-187577", "R-MMU-8852276", "R-SCE-6798695", "R-MMU-68949", "R-CEL-9907900", "R-HSA-9824272", "R-MMU-174178", "R-CEL-983168", "R-DDI-9013422", "R-MMU-349425", "R-MMU-8939236", "R-CEL-8854050", "R-HSA-9907900", "R-MMU-6781823", "R-DME-350562", "R-DME-174084", "R-DME-9907900", "R-DDI-5689603", "R-CEL-75815", "R-DDI-69601", "R-DDI-2467813", "R-DME-9929491", "R-MMU-9762114", "R-HSA-9762114", "R-DDI-5689880", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-MMU-382556", "R-HSA-5610780", "R-DME-209360", "R-DDI-5687128", "R-CEL-9755511", "R-DME-6798695", "R-DDI-9907900", "R-SCE-1236978", "R-DME-8939236", "R-MMU-1169091", "R-DME-174184", "R-DME-432626", "R-DME-9013422", "R-MMU-5607761", "R-MMU-5676590", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-MMU-174184", "R-MMU-8939902", "R-HSA-8856825", "R-DME-174178", "R-DME-9932298", "R-DME-9020702", "R-CEL-9762114", "R-HSA-8939236", "R-HSA-5358346", "R-CEL-8951664", "R-CEL-4641257", "R-DDI-8854050", "R-HSA-6798695", "R-SPO-350562", "R-DME-5689880", "R-MMU-5632684", "R-HSA-9013422", "R-SPO-9907900", "R-MMU-5607764", "R-DME-6781823", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-DME-8951664", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-DDI-1236978", "R-HSA-6781823", "R-DDI-5632684", "R-DDI-8951664", "R-MMU-8951664", "R-MMU-9013422", "R-DME-8939902", "R-CEL-382556", "R-CEL-5689603", "R-HSA-4641257", "R-MMU-9929491", "R-HSA-174113", "R-MMU-9929356", "R-DME-4608870", "R-SCE-5668541", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-HSA-69481", "R-DME-9762114", "R-CEL-4641258", "R-DDI-5658442", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-DDI-6781823", "R-HSA-9755511", "R-HSA-4641258", "R-CEL-9929491", "R-SPO-5689603", "R-DME-9755511", "R-DME-1236978", "R-CEL-6781823", "R-HSA-180585", "R-SPO-1236978", "R-HSA-1169091", "R-CEL-69017", "R-HSA-4608870", "R-HSA-5658442", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-DME-450408", "R-DME-8941858", "R-SPO-6798695", "R-HSA-187577", "R-MMU-5610780", "R-DME-9954709", "R-DME-1169091", "R-DDI-9755511", "R-MMU-8856825", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-DDI-75815", "R-MMU-350562", "R-MMU-69601", "R-DME-195253", "R-HSA-2871837", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-DME-5607761", "R-MMU-5658442", "R-MMU-5689603", "R-DME-5689603", "R-HSA-174084", "R-DME-216167", "R-MMU-4608870", "R-HSA-5607764", "R-DME-68949", "R-DDI-69017", "R-DME-8856825", "R-CEL-1236978", "R-RNO-8856825", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-HSA-5687128", "R-DDI-349425", "R-HSA-202424", "R-HSA-69017", "R-DME-5632684", "R-DME-432395", "R-MMU-983168", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-HSA-350562", "R-DDI-174178", "R-DDI-174154", "R-DME-68867"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5689880:r:Ub-specific processing proteases", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-4641258:r:Degradation of DVL", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-8951664:r:Neddylation", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9766229:r:Degradation of CDH1", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-9907900:r:Proteasome assembly", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-432626:r:Circadian Clock pathway", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-DME-9020702:r:Interleukin-1 signaling", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-CEL-4641257:r:Degradation of AXIN", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CEL-5689603:r:UCH proteinases", "R-HSA-4641257:r:Degradation of AXIN", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-4641258:r:Degradation of DVL", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-5689603:r:UCH proteinases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5689603:r:UCH proteinases", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-68949:r:Orc1 removal from chromatin", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen 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"R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR045136": {"description": "Isoamyl acetate-hydrolyzing esterase Iah1-like", "go_ids": [], "go_terms": [], "name": "Iah1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045137": {"description": "RNA-binding protein 26/27", "go_ids": [], "go_terms": [], "name": "RBM26/27", "pathway_ids": ["R-MMU-9930044", "R-DME-9930044", "R-HSA-9930044", "R-SPO-9930044"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-DME-9930044:r:Nuclear RNA decay", "R-HSA-9930044:r:Nuclear RNA decay", "R-SPO-9930044:r:Nuclear RNA decay"], "type": "Family"}, "IPR045138": {"description": "Methyl-CpG binding protein MeCP2/MBD4", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "MeCP2/MBD4", "pathway_ids": ["R-HSA-9022702", "R-HSA-9725371", "R-HSA-9022927", "R-HSA-110357", "R-HSA-9022535", "R-HSA-9022692", "R-RNO-9022692", "R-MMU-9022692", "R-HSA-110329", "R-HSA-9022537", "R-HSA-110328", "R-HSA-9022699", "R-HSA-9022538", "R-HSA-9022534", "R-HSA-8986944", "R-MMU-110329", "R-MMU-110357", "R-HSA-9022707"], "pathways": ["R-HSA-9022702:r:MECP2 regulates transcription of neuronal ligands", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9022927:r:MECP2 regulates transcription of genes involved in GABA signaling", "R-HSA-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9022535:r:Loss of phosphorylation of MECP2 at T308", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-RNO-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-9022537:r:Loss of MECP2 binding ability to the NCoR/SMRT complex", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-HSA-9022538:r:Loss of MECP2 binding ability to 5mC-DNA", "R-HSA-9022534:r:Loss of MECP2 binding ability to 5hmC-DNA", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-MMU-110329:r:Cleavage of the damaged pyrimidine", "R-MMU-110357:r:Displacement of DNA glycosylase by APEX1", "R-HSA-9022707:r:MECP2 regulates transcription factors"], "type": "Family"}, "IPR045139": {"description": "Aladin", "go_ids": [], "go_terms": [], "name": "Aladin", "pathway_ids": ["R-HSA-180910", "R-MMU-3232142", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-8980692", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", 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"go_ids": ["GO:0030968", "GO:0036503"], "go_terms": ["GO:0030968:endoplasmic reticulum unfolded protein response:P", "GO:0036503:ERAD pathway:P"], "name": "OS-9-like", "pathway_ids": ["R-MMU-382556", "R-HSA-9931269", "R-HSA-901032", "R-HSA-382556", "R-HSA-5678895", "R-RNO-382556", "R-RNO-9931269", "R-XTR-5358346", "R-XTR-9931269", "R-MMU-5358346", "R-MMU-9931269", "R-HSA-5362768", "R-XTR-382556", "R-RNO-5358346", "R-HSA-5358346"], "pathways": ["R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-XTR-5358346:r:Hedgehog ligand biogenesis", "R-XTR-9931269:r:AMPK-induced ERAD and lysosome 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"R-MMU-430039", "R-DME-430039", "R-DRE-430039", "R-HSA-430039"], "pathways": ["R-RNO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DME-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Family"}, "IPR045153": {"description": "Est1/Ebs1-like", "go_ids": [], "go_terms": [], "name": "Est1/Ebs1-like", "pathway_ids": ["R-HSA-975957", "R-SPO-975957", "R-DRE-975957", "R-SCE-975957", "R-MMU-975957"], "pathways": ["R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "type": "Family"}, "IPR045154": {"description": "Protein PCF11-like", "go_ids": ["GO:0003729", "GO:0031124", "GO:0006369", "GO:0000993"], "go_terms": ["GO:0003729:mRNA binding:F", "GO:0031124:mRNA 3'-end processing:P", "GO:0006369:termination of RNA polymerase II transcription:P", "GO:0000993:RNA polymerase II complex binding:F"], "name": "PCF11-like", "pathway_ids": ["R-HSA-77595", "R-SCE-9770562", "R-SPO-9770562", "R-CEL-6807505", "R-MMU-72187", "R-HSA-6807505", "R-HSA-9770562", "R-MMU-9770562", "R-CEL-9770562", "R-MMU-77595", "R-MMU-73856", "R-HSA-73856", "R-HSA-72187", "R-CEL-73856", "R-HSA-9918481", "R-MMU-6807505", "R-CEL-77595"], "pathways": ["R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SCE-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Family"}, "IPR045155": {"description": "Beta-lactamase class A, catalytic domain", "go_ids": ["GO:0008800", "GO:0017001", "GO:0030655"], "go_terms": ["GO:0008800:beta-lactamase activity:F", "GO:0017001:antibiotic catabolic process:P", "GO:0030655:beta-lactam antibiotic catabolic process:P"], "name": "Beta-lactam_cat", "pathway_ids": ["R-HSA-9913143"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance"], "type": "Domain"}, "IPR045156": {"description": "Vacuolar protein 8", "go_ids": ["GO:0071562", "GO:0043495"], "go_terms": ["GO:0071562:nucleus-vacuole junction assembly:P", "GO:0043495:protein-membrane adaptor activity:F"], "name": "Vac8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045157": {"description": "CagA, N-terminal", "go_ids": [], "go_terms": [], "name": "CagA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045158": {"description": "K(+) efflux antiporter 4/5/6-like", "go_ids": ["GO:0071805", "GO:0015386", "GO:1902600"], "go_terms": ["GO:0071805:potassium ion transmembrane transport:P", "GO:0015386:potassium:proton antiporter activity:F", "GO:1902600:proton transmembrane transport:P"], "name": "KEA4/5/6-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045159": {"description": "WD repeat-containing protein DCAF7-like", "go_ids": [], "go_terms": [], "name": "DCAF7-like", "pathway_ids": ["R-MMU-8951664", "R-SPO-8951664", "R-HSA-390471", "R-HSA-8951664", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation"], "type": "Family"}, "IPR045160": {"description": "Autophagy-related protein 16", "go_ids": ["GO:0000045"], "go_terms": ["GO:0000045:autophagosome assembly:P"], "name": "ATG16", "pathway_ids": ["R-CEL-1632852", "R-DDI-1632852", "R-MMU-1632852", "R-XTR-1632852", "R-HSA-1632852"], "pathways": ["R-CEL-1632852:r:Macroautophagy", "R-DDI-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy"], "type": "Family"}, "IPR045161": {"description": "U3 small nucleolar RNA-associated protein 18", "go_ids": ["GO:0006364"], "go_terms": ["GO:0006364:rRNA processing:P"], "name": "Utp18", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR045162": {"description": "Serine/threonine-protein kinase Vps15-like", "go_ids": ["GO:0004674", "GO:0045324", "GO:0016236"], "go_terms": ["GO:0004674:protein serine/threonine kinase activity:F", "GO:0045324:late endosome to vacuole transport:P", "GO:0016236:macroautophagy:P"], "name": "Vps15-like", "pathway_ids": ["R-SCE-1660516", "R-HSA-9679504", "R-HSA-1660517", "R-HSA-9705671", "R-MMU-1660516", "R-SCE-1660514", "R-MMU-1632852", "R-RNO-109704", "R-RNO-1660514", "R-SPO-1660516", "R-RNO-5668599", "R-RNO-168138", "R-RNO-1632852", "R-RNO-1660516", "R-SCE-1660517", "R-SPO-5668599", "R-MMU-5668599", "R-MMU-1660514", "R-HSA-5668599", "R-HSA-9920951", "R-DDI-1660517", "R-DDI-5668599", "R-HSA-9694676", "R-HSA-168138", "R-DDI-1632852", "R-MMU-109704", "R-DDI-1660516", "R-SPO-1660514", "R-HSA-109704", "R-HSA-1660514", "R-HSA-1660516", "R-HSA-983170", "R-SCE-1632852", "R-RNO-1660517", "R-HSA-1632852", "R-SPO-1660517", "R-SCE-5668599", "R-DDI-1660514", "R-MMU-168138", "R-MMU-1660517", "R-SPO-1632852"], "pathways": ["R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1632852:r:Macroautophagy", "R-RNO-109704:r:PI3K Cascade", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-RNO-1632852:r:Macroautophagy", "R-RNO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-DDI-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-DDI-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-DDI-1632852:r:Macroautophagy", "R-MMU-109704:r:PI3K Cascade", "R-DDI-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-109704:r:PI3K Cascade", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-1632852:r:Macroautophagy", "R-RNO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-1632852:r:Macroautophagy", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-1632852:r:Macroautophagy"], "type": "Family"}, "IPR045163": {"description": "Focadhesin/RST1", "go_ids": ["GO:0060147"], "go_terms": ["GO:0060147:regulation of post-transcriptional gene silencing:P"], "name": "Focadhesin/RST1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045164": {"description": "RNA-binding region-containing protein RBM41/RNPC3", "go_ids": [], "go_terms": [], "name": "RBM41/RNPC3", "pathway_ids": ["R-HSA-72165", "R-MMU-72165", "R-RNO-72165", "R-DRE-72165"], "pathways": ["R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-DRE-72165:r:mRNA Splicing - Minor Pathway"], "type": "Family"}, "IPR045165": {"description": "Nitrobindin family", "go_ids": [], "go_terms": [], "name": "Nitrobindin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045166": {"description": "Pre-mRNA-splicing factor Spp2-like", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "Spp2-like", "pathway_ids": ["R-HSA-9918481", "R-HSA-72163", "R-MMU-72163", "R-CEL-72163"], "pathways": ["R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR045167": {"description": "Hobbit", "go_ids": [], "go_terms": [], "name": "Hobbit", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045168": {"description": "YTH domain containing protein", "go_ids": [], "go_terms": [], "name": "YTH_prot", "pathway_ids": ["R-MMU-9930044", "R-RNO-9930044", "R-HSA-9930044", "R-DME-9930044"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-RNO-9930044:r:Nuclear RNA decay", "R-HSA-9930044:r:Nuclear RNA decay", "R-DME-9930044:r:Nuclear RNA decay"], "type": "Family"}, "IPR045169": {"description": "Nitrite and sulphite reductase 4Fe-4S domain containing protein", "go_ids": ["GO:0016491", "GO:0020037", "GO:0051536"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0020037:heme binding:F", "GO:0051536:iron-sulfur cluster binding:F"], "name": "NO2/SO3_Rdtase_4Fe4S_prot", "pathway_ids": ["PWY-6683"], "pathways": ["PWY-6683:t:assimilatory sulfate reduction III"], "type": "Family"}, "IPR045170": {"description": "MTOX", "go_ids": ["GO:0016491", "GO:0050660"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0050660:flavin adenine dinucleotide binding:F"], "name": "MTOX", "pathway_ids": ["PWY-7638", "PWY-7542", "R-BTA-9033241", "R-SPO-9033241", "R-MMU-71064", "R-CEL-71064", "R-SPO-71064", "R-HSA-71064", "R-MMU-9033241", "R-BTA-71064", "R-HSA-9033241"], "pathways": ["PWY-7638:t:echinenone and zeaxanthin biosynthesis (Synechocystis)", "PWY-7542:t:fumiquinazoline D biosynthesis", "R-BTA-9033241:r:Peroxisomal protein import", "R-SPO-9033241:r:Peroxisomal protein import", "R-MMU-71064:r:Lysine catabolism", "R-CEL-71064:r:Lysine catabolism", "R-SPO-71064:r:Lysine catabolism", "R-HSA-71064:r:Lysine catabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-BTA-71064:r:Lysine catabolism", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR045173": {"description": "DNA replication factor Cdt1", "go_ids": ["GO:0030174", "GO:0003677", "GO:0071163"], "go_terms": ["GO:0030174:regulation of DNA-templated DNA replication initiation:P", "GO:0003677:DNA binding:F", "GO:0071163:DNA replication preinitiation complex assembly:P"], "name": "Cdt1", "pathway_ids": ["R-MMU-68867", "R-HSA-68949", "R-HSA-69052", "R-HSA-69205", "R-MMU-68962", "R-HSA-68962", "R-SPO-68962", "R-MMU-68949", "R-SPO-68949", "R-MMU-69052", "R-HSA-68867"], "pathways": ["R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-SPO-68949:r:Orc1 removal from chromatin", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Family"}, "IPR045174": {"description": "Dof zinc finger protein", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "Dof", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045175": {"description": "Peptidase M28 family", "go_ids": ["GO:0006508", "GO:0008235"], "go_terms": ["GO:0006508:proteolysis:P", "GO:0008235:metalloexopeptidase activity:F"], "name": "M28_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045176": {"description": "Protein transport protein Got1", "go_ids": ["GO:0006888"], "go_terms": ["GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P"], "name": "Got1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045177": {"description": "Factor of DNA methylation 1-5/IDN2", "go_ids": ["GO:0080188"], "go_terms": ["GO:0080188:gene silencing by siRNA-directed DNA methylation:P"], "name": "FDM1-5/IDN2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045178": {"description": "Transcription regulator Fhl1/FHA1", "go_ids": ["GO:0060962"], "go_terms": ["GO:0060962:regulation of ribosomal protein gene transcription by RNA polymerase II:P"], "name": "Fhl1/FHA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045179": {"description": "YgfZ/GcvT", "go_ids": [], "go_terms": [], "name": "YgfZ/GcvT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045180": {"description": "La domain containing protein", "go_ids": [], "go_terms": [], "name": "La_dom_prot", "pathway_ids": ["R-HSA-73980", "R-HSA-749476", "R-HSA-9705671"], "pathways": ["R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses"], "type": "Family"}, "IPR045182": {"description": "Protein JINGUBANG-like", "go_ids": [], "go_terms": [], "name": "JINGUBANG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045183": {"description": "F-box-like/WD repeat-containing protein Ebi-like", "go_ids": ["GO:0003714"], "go_terms": ["GO:0003714:transcription corepressor activity:F"], "name": "Ebi-like", "pathway_ids": ["R-HSA-1989781", "R-DME-350054", "R-HSA-2151201", "R-HSA-9022692", "R-HSA-1368108", "R-HSA-9841922", "R-SPO-9772755", "R-HSA-9933387", "R-HSA-9707564", "R-MMU-9841922", "R-DME-400206", "R-HSA-9029569", "R-MMU-9029569", "R-HSA-2122947", "R-HSA-9931509", "R-HSA-2426168", "R-DME-9707564", "R-HSA-2894862", "R-HSA-9022537", "R-HSA-381340", "R-HSA-9707616", "R-HSA-3214815", "R-HSA-9609690", "R-HSA-350054", "R-MMU-350054", "R-DME-9841922", "R-HSA-400206", "R-SPO-8951664", "R-HSA-2644606", "R-DME-9029569", "R-MMU-400206", "R-MMU-9707564"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-350054:r:Notch-HLH transcription pathway", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9022537:r:Loss of MECP2 binding ability to the NCoR/SMRT complex", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-DME-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR045184": {"description": "WD40 repeat-containing protein SMU1", "go_ids": ["GO:0000398"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P"], "name": "SMU1", "pathway_ids": ["R-HSA-72163", "R-MMU-72163", "R-CEL-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR045185": {"description": "E3 ubiquitin-protein ligase PUB22/23/24-like", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "PUB22/23/24-like", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR045186": {"description": "Indole-3-glycerol phosphate synthase", "go_ids": ["GO:0004425"], "go_terms": ["GO:0004425:indole-3-glycerol-phosphate synthase activity:F"], "name": "Indole-3-glycerol_P_synth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045187": {"description": "Cytochrome c/quinol oxidase subunit II", "go_ids": ["GO:0004129"], "go_terms": ["GO:0004129:cytochrome-c oxidase activity:F"], "name": "CcO_II", "pathway_ids": ["PWY-7429", "PWY-8271", "PWY-3781", "PWY-6692", "PWY-4521", "PWY-7279", "R-GGA-9707564", "R-HSA-5419276", "R-DRE-611105", "R-DME-9707564", "R-GGA-9864848", "R-RNO-5628897", "R-DRE-9864848", "R-RNO-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-DME-611105", "R-BTA-5628897", "R-HSA-9864848", "R-HSA-611105", "R-RNO-611105", "R-GGA-5419276", "R-DME-9864848", "R-RNO-5419276", "R-GGA-5628897", "R-BTA-611105", "R-HSA-9707564", "R-GGA-611105", "R-MMU-5628897", "R-MMU-611105", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9837999", "R-MMU-9864848", "R-BTA-5419276", "R-CEL-5419276", "R-DRE-9707564", "R-DRE-5419276", "R-DRE-5628897", "R-RNO-9864848", "R-MMU-9707564", "R-DME-5628897", "R-BTA-9707564"], "pathways": ["PWY-7429:t:arsenite to oxygen electron transfer (via azurin)", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)", "PWY-3781:t:aerobic respiration I (cytochrome c)", "PWY-6692:t:Fe(II) oxidation", "PWY-4521:t:arsenite to oxygen electron transfer", "PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "R-GGA-9707564:r:Cytoprotection by HMOX1", "R-HSA-5419276:r:Mitochondrial translation termination", "R-DRE-611105:r:Respiratory electron transport", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-GGA-9864848:r:Complex IV assembly", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-9864848:r:Complex IV assembly", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-BTA-9864848:r:Complex IV assembly", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-611105:r:Respiratory electron transport", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-GGA-5419276:r:Mitochondrial translation termination", "R-DME-9864848:r:Complex IV assembly", "R-RNO-5419276:r:Mitochondrial translation termination", "R-GGA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-611105:r:Respiratory electron transport", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-GGA-611105:r:Respiratory electron transport", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-611105:r:Respiratory electron transport", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9864848:r:Complex IV assembly", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DRE-5419276:r:Mitochondrial translation termination", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9864848:r:Complex IV assembly", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR045188": {"description": "PH domain containing protein Boi1/Boi2-like", "go_ids": [], "go_terms": [], "name": "Boi1/Boi2-like", "pathway_ids": ["R-SCE-1660499", "R-HSA-1660499", "R-MMU-1660499"], "pathways": ["R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Family"}, "IPR045189": {"description": "E3 ubiquitin ligase UBR4-like", "go_ids": [], "go_terms": [], "name": "UBR4-like", "pathway_ids": ["R-DDI-6798695", "R-DDI-983168", "R-HSA-6798695", "R-DME-983168", "R-HSA-9920588", "R-DME-6798695", "R-CEL-6798695", "R-MMU-983168", "R-MMU-6798695", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR045190": {"description": "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like", "go_ids": [], "go_terms": [], "name": "MCCB/AccD1-like", "pathway_ids": ["R-CEL-196780", "R-RNO-196780", "R-DME-196780", "R-DDI-196780", "R-MMU-70895", "R-CEL-70895", "R-DDI-70895", "R-HSA-9909438", "R-HSA-196780", "R-HSA-70895", "R-DME-70895", "R-HSA-3371599", "R-MMU-196780", "R-RNO-70895"], "pathways": ["R-CEL-196780:r:Biotin transport and metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-DME-196780:r:Biotin transport and metabolism", "R-DDI-196780:r:Biotin transport and metabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-CEL-70895:r:Branched-chain amino acid catabolism", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-9909438:r:3-Methylcrotonyl-CoA carboxylase deficiency", "R-HSA-196780:r:Biotin transport and metabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-DME-70895:r:Branched-chain amino acid catabolism", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-196780:r:Biotin transport and metabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Family"}, "IPR045191": {"description": "E3 ubiquitin-protein ligase MBR1/2-like", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "MBR1/2-like", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR045192": {"description": "Clathrin coat assembly protein AP180-like", "go_ids": ["GO:0072583", "GO:0048268"], "go_terms": ["GO:0072583:clathrin-dependent endocytosis:P", "GO:0048268:clathrin coat assembly:P"], "name": "AP180-like", "pathway_ids": ["R-DME-8856825", "R-MMU-8856828", "R-CEL-8856828", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-RNO-9696264", "R-MMU-432722", "R-DME-8856828", "R-RNO-8856828", "R-CEL-432722", "R-MMU-9696264", "R-DME-432722", "R-HSA-432722", "R-CEL-8856825", "R-RNO-432722", "R-HSA-9696264"], "pathways": ["R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9696264:r:RND3 GTPase cycle", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Family"}, "IPR045194": {"description": "E3 ubiquitin-protein ligase MGRN1/RNF157-like", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "MGRN1/RNF157-like", "pathway_ids": ["PWY-7511", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR045196": {"description": "Translation initiation factor IF2/IF5", "go_ids": ["GO:0003743", "GO:0006413"], "go_terms": ["GO:0003743:translation initiation factor activity:F", "GO:0006413:translational initiation:P"], "name": "IF2/IF5", "pathway_ids": ["R-SCE-72702", "R-MMU-72695", "R-HSA-9840373", "R-MMU-382556", "R-SCE-156827", "R-DME-72695", "R-MMU-72702", "R-DME-72731", "R-SPO-72706", "R-SPO-72649", "R-SPO-72695", "R-DDI-72695", "R-HSA-382556", "R-SPO-9840373", "R-HSA-72706", "R-RNO-72702", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-DME-9840373", "R-CEL-156827", "R-SCE-9840373", "R-HSA-9648895", "R-DDI-9840373", "R-SCE-72649", "R-CEL-72731", "R-DDI-72731", "R-CEL-72649", "R-CEL-9840373", "R-SPO-156827", "R-DDI-381042", "R-DME-72702", "R-DDI-156827", "R-DDI-72702", "R-MMU-9840373", "R-HSA-9633012", "R-HSA-72731", "R-SCE-382556", "R-SPO-382556", "R-SPO-72702", "R-DDI-382556", "R-DME-156827", "R-HSA-9833482", "R-DME-382556", "R-HSA-381042", "R-CEL-72702", "R-DME-72649", "R-SPO-72731", "R-HSA-156827", "R-CEL-72695", "R-CEL-381042", "R-DME-381042", "R-HSA-72695", "R-MMU-381042", "R-MMU-72649", "R-MMU-72706", "R-SCE-72731", "R-MMU-72731", "R-CEL-382556", "R-SCE-72695"], 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"R-DDI-381042:r:PERK regulates gene expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9833482:r:PKR-mediated signaling", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-381042:r:PERK regulates gene expression", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation 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"R-HSA-72203", "R-MMU-6796648", "R-HSA-9770562", "R-BTA-72165", "R-HSA-167243", "R-SCE-6781823", "R-BTA-674695", "R-SCE-9018519", "R-BTA-6803529", "R-HSA-167290", "R-MMU-77075", "R-HSA-75955", "R-MMU-72165", "R-SPO-6782210", "R-DME-6782210", "R-HSA-76042", "R-HSA-674695", "R-BTA-6807505", "R-BTA-72203", "R-SPO-72163", "R-HSA-112382", "R-HSA-73779", "R-MMU-72203", "R-HSA-167238", "R-SCE-75953", "R-MMU-113418", "R-DME-6781823", "R-DME-76042", "R-BTA-76042", "R-SPO-6807505", "R-HSA-6796648", "R-HSA-6781823", "R-HSA-167287", "R-HSA-167246", "R-HSA-75953", "R-HSA-77075", "R-SPO-72086", "R-MMU-73779", "R-HSA-9018519", "R-MMU-76042", "R-HSA-5601884", "R-SPO-75953", "R-SPO-113418", "R-DDI-73779", "R-DME-674695", "R-BTA-72086", "R-DME-9018519", "R-DDI-6781823", "R-DDI-72203", "R-HSA-168325", "R-DDI-72086", "R-MMU-674695", "R-MMU-6807505", "R-SCE-76042", "R-DDI-6807505", "R-MMU-9018519", "R-DME-6807505", "R-SPO-9770562", "R-HSA-167200", "R-DME-72165", "R-SCE-674695", "R-BTA-9770562", "R-MMU-6782210", "R-HSA-5617472", "R-SCE-6782135", "R-MMU-6803529", "R-DDI-6782135", "R-MMU-6782135", "R-BTA-113418", "R-DME-6796648", "R-HSA-72086", "R-DDI-9770562", "R-HSA-167162", "R-HSA-167152", "R-HSA-113418", "R-BTA-112382", "R-SCE-6782210", "R-HSA-9918481", "R-BTA-6796648", "R-SPO-72203", "R-SCE-6796648", "R-SCE-72203", "R-SPO-77075", "R-SCE-113418", "R-SCE-72086", "R-HSA-6782135", "R-SCE-77075", "R-DDI-75953", "R-SPO-6782135"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-9018519:r:Estrogen-dependent gene expression", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-72086:r:mRNA Capping", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-6782135:r:Dual incision in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-BTA-6782135:r:Dual incision in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-167161:r:HIV Transcription Initiation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-DDI-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-5578749:r:Transcriptional regulation by small RNAs", "R-DME-5578749:r:Transcriptional regulation by small RNAs", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-5578749:r:Transcriptional regulation by small RNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-BTA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-72086:r:mRNA Capping", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DDI-72086:r:mRNA Capping", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-SCE-6782135:r:Dual incision in TC-NER", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-DDI-6782135:r:Dual incision in TC-NER", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-113418:r:Formation of the Early Elongation Complex", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-72086:r:mRNA Capping", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-BTA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-HSA-6782135:r:Dual incision in TC-NER", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-6782135:r:Dual incision in TC-NER"], "type": "Family"}, "IPR045223": {"description": "Small ribosomal subunit protein RACK1-like", "go_ids": ["GO:0045182", "GO:0043022"], "go_terms": ["GO:0045182:translation regulator activity:F", "GO:0043022:ribosome binding:F"], "name": "RACK1-like", "pathway_ids": ["R-MMU-9766229", "R-SSC-9766229", "R-DME-5357905", "R-HSA-5626978", "R-BTA-5357956", "R-BTA-5626978", "R-DRE-5626978", "R-HSA-9766229", "R-RNO-5357905", "R-SSC-5357905", "R-MMU-5357956", "R-SSC-5357956", "R-SSC-5626978", "R-DRE-5357905", "R-HSA-5357905", "R-HSA-5357956", "R-RNO-5626978", "R-MMU-5357905", "R-RNO-9766229", "R-RNO-5357956", "R-MMU-5626978", "R-BTA-5357905", "R-BTA-9766229"], "pathways": ["R-MMU-9766229:r:Degradation of CDH1", "R-SSC-9766229:r:Degradation of CDH1", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5626978:r:TNFR1-mediated ceramide production", "R-DRE-5626978:r:TNFR1-mediated ceramide production", "R-HSA-9766229:r:Degradation of CDH1", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-5626978:r:TNFR1-mediated ceramide production", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-9766229:r:Degradation of CDH1"], "type": "Family"}, "IPR045224": {"description": "Homeobox-leucine zipper protein, class I, plant", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "HDZip_class_I_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045225": {"description": "Uracil/uridine/allantoin permease", "go_ids": ["GO:0055085", "GO:0022857", "GO:0016020"], "go_terms": ["GO:0055085:transmembrane transport:P", "GO:0022857:transmembrane transporter activity:F", "GO:0016020:membrane:C"], "name": "Uracil/uridine/allantoin_perm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045226": {"description": "DSC E3 ubiquitin ligase complex subunit 3", "go_ids": ["GO:0044695"], "go_terms": ["GO:0044695:Dsc E3 ubiquitin ligase complex:C"], "name": "Dsc3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045227": {"description": "WD repeat-containing protein WDR18/Ipi3/RID3", "go_ids": [], "go_terms": [], "name": "WDR18/Ipi3/RID3", "pathway_ids": ["R-MMU-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-DRE-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR045229": {"description": "Thiamine pyrophosphate enzyme", "go_ids": [], "go_terms": [], "name": "TPP_enz", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045230": {"description": "Transcriptional regulator ZNF706/MBS1/2-like", "go_ids": [], "go_terms": [], "name": "ZNF706/MBS1/2-like", "pathway_ids": ["R-MMU-212436", "R-HSA-212436", "R-GGA-212436"], "pathways": ["R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway", "R-GGA-212436:r:Generic Transcription Pathway"], "type": "Family"}, "IPR045231": {"description": "Protein Yip1/4-like", "go_ids": ["GO:0006888"], "go_terms": ["GO:0006888:endoplasmic reticulum to Golgi vesicle-mediated transport:P"], "name": "Yip1/4-like", "pathway_ids": ["R-BTA-432722", "R-HSA-432722", "R-XTR-432722", "R-RNO-432722", "R-MMU-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-XTR-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR045232": {"description": "Protein FAM234", "go_ids": [], "go_terms": [], "name": "FAM234", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045234": {"description": "RING finger protein Unkempt-like", "go_ids": [], "go_terms": [], "name": "Unkempt-like", "pathway_ids": ["R-DME-983168", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR045237": {"description": "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7", "go_ids": [], "go_terms": [], "name": "COPS7/eIF3m", "pathway_ids": ["R-CEL-72689", "R-SPO-72702", "R-BTA-8951664", "R-DME-156827", "R-MMU-8856825", "R-DME-6781823", "R-HSA-8951664", "R-MMU-72689", "R-DME-8951664", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-XTR-72702", "R-CEL-72695", "R-MMU-72649", "R-HSA-72695", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-72706", "R-SPO-72689", "R-DDI-8856825", "R-MMU-8951664", "R-BTA-6781823", "R-MMU-6781823", "R-MMU-5696394", "R-XTR-72695", "R-MMU-72695", "R-DME-8856825", "R-DRE-156827", "R-DME-72695", "R-MMU-72702", "R-DDI-72702", "R-SPO-72706", "R-SPO-72649", "R-DRE-72695", "R-SPO-72695", "R-BTA-5696394", "R-DDI-72695", "R-XTR-156827", 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"R-RNO-5682910:r:LGI-ADAM interactions", "R-CEL-5694530:r:Cargo concentration in the ER", "R-DME-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-6811438:r:Intra-Golgi traffic", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-SPO-5694530:r:Cargo concentration in the ER", "R-BTA-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-199992:r:trans-Golgi Network Vesicle Budding", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SPO-6811438:r:Intra-Golgi traffic", "R-BTA-5694530:r:Cargo concentration in the ER", "R-DME-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-5682910:r:LGI-ADAM interactions", "R-BTA-8980692:r:RHOA GTPase cycle", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5250971:r:Toxicity of botulinum toxin type C (botC)", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-BTA-9013106:r:RHOC GTPase cycle", "R-DME-204005:r:COPII-mediated vesicle transport", "R-HSA-114516:r:Disinhibition of SNARE formation", "R-HSA-449836:r:Other interleukin signaling", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-6811438:r:Intra-Golgi traffic", "R-RNO-114516:r:Disinhibition of SNARE formation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DME-888590:r:GABA synthesis, release, reuptake and degradation", "R-DME-449836:r:Other interleukin signaling", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-CEL-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-BTA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DME-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-CEL-6811438:r:Intra-Golgi traffic", "R-DME-181429:r:Serotonin Neurotransmitter Release Cycle", "R-BTA-449836:r:Other interleukin signaling", "R-DME-199992:r:trans-Golgi Network Vesicle Budding", "R-BTA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-5694530:r:Cargo concentration in the ER", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-SCE-114516:r:Disinhibition of SNARE formation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-449836:r:Other interleukin signaling", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-SCE-9013106:r:RHOC GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-6811438:r:Intra-Golgi traffic", "R-DME-114516:r:Disinhibition of SNARE formation", "R-BTA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-5682910:r:LGI-ADAM interactions", "R-BTA-6811438:r:Intra-Golgi traffic", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-422356:r:Regulation of insulin secretion"], "type": "Family"}, "IPR045243": {"description": "mRNA 3'-end-processing protein Rna14-like", "go_ids": ["GO:0031124"], "go_terms": ["GO:0031124:mRNA 3'-end processing:P"], "name": "Rna14-like", "pathway_ids": ["R-DME-9770562", "R-SPO-9770562", "R-HSA-77595", "R-MMU-72187", "R-HSA-9770562", "R-DME-77595", "R-MMU-9770562", "R-MMU-77595", "R-HSA-73856", "R-MMU-73856", "R-DME-73856", "R-HSA-72187", "R-HSA-9918481"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR045244": {"description": "Phosphoglucomutase", "go_ids": ["GO:0004614", "GO:0005975"], "go_terms": ["GO:0004614:phosphoglucomutase activity:F", "GO:0005975:carbohydrate metabolic process:P"], "name": "PGM", "pathway_ids": ["PWY-6731", "PWY-7343", "PWY-5661", "PWY-5941", "PWY-6737", "PWY-7238", "PWY-7902", "PWY-622", "PWY-7900", "PWY-5940", "PWY-6981", "PWY-5384", "PWY-8139", "PWY-3801", "PWY-6317", "PWY-2723", "R-MMU-70221", "R-HSA-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-HSA-70221", "R-SPO-3322077", "R-MMU-3322077", "R-DME-70221", "R-DME-6798695", "R-SCE-6798695", "R-SCE-3322077", "R-SPO-70370", "R-SCE-70370", "R-DDI-3322077", "R-MMU-70370", "R-RNO-70221", "R-SCE-70221", "R-SPO-70221", "R-HSA-3322077", "R-DDI-70370", "R-HSA-70370", "R-MMU-6798695", "R-HSA-5609974", "R-RNO-70370", "R-DME-70370", "R-DME-3322077", "R-RNO-3322077", "R-RNO-6798695", "R-DDI-70221"], "pathways": ["PWY-6731:t:starch degradation III", "PWY-7343:t:UDP-alpha-D-glucose biosynthesis", "PWY-5661:t:GDP-alpha-D-glucose biosynthesis", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V", "PWY-7238:t:sucrose biosynthesis II", "PWY-7902:t:glucosylglycerol biosynthesis", "PWY-622:t:starch biosynthesis", "PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)", "PWY-5940:t:streptomycin biosynthesis", "PWY-6981:t:chitin biosynthesis", "PWY-5384:t:sucrose degradation IV (sucrose phosphorylase)", "PWY-8139:t:CDP-6-deoxy-D-gulose biosynthesis", "PWY-3801:t:sucrose degradation II (sucrose synthase)", "PWY-6317:t:D-galactose degradation I (Leloir pathway)", "PWY-2723:t:trehalose degradation V", "R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-SPO-3322077:r:Glycogen synthesis", "R-MMU-3322077:r:Glycogen synthesis", "R-DME-70221:r:Glycogen breakdown (glycogenolysis)", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-3322077:r:Glycogen synthesis", "R-SPO-70370:r:Galactose catabolism", "R-SCE-70370:r:Galactose catabolism", "R-DDI-3322077:r:Glycogen synthesis", "R-MMU-70370:r:Galactose catabolism", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-SPO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-3322077:r:Glycogen synthesis", "R-DDI-70370:r:Galactose catabolism", "R-HSA-70370:r:Galactose catabolism", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5609974:r:Defective PGM1 causes PGM1-CDG", "R-RNO-70370:r:Galactose catabolism", "R-DME-70370:r:Galactose catabolism", "R-DME-3322077:r:Glycogen synthesis", "R-RNO-3322077:r:Glycogen synthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-70221:r:Glycogen breakdown (glycogenolysis)"], "type": "Family"}, "IPR045245": {"description": "Pre-mRNA 3' end processing protein Pfs2-like", "go_ids": ["GO:0031124"], "go_terms": ["GO:0031124:mRNA 3'-end processing:P"], "name": "Pfs2-like", "pathway_ids": ["R-CEL-159231", "R-HSA-9770562", "R-MMU-9770562", "R-SPO-159231", "R-SCE-77595", "R-MMU-77595", "R-MMU-73856", "R-HSA-73856", "R-HSA-72187", "R-CEL-73856", "R-SPO-77595", "R-HSA-159231", "R-CEL-77595", "R-HSA-77595", "R-SPO-9770562", "R-MMU-72187", "R-CEL-9770562", "R-HSA-9918481", "R-MMU-159231"], "pathways": ["R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript"], "type": "Family"}, "IPR045247": {"description": "Oxidoreductase Oye-like", "go_ids": ["GO:0016491", "GO:0010181"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0010181:FMN binding:F"], "name": "Oye-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045249": {"description": "Putative nuclease HARBI1-like", "go_ids": [], "go_terms": [], "name": "HARBI1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045250": {"description": "Co-chaperone protein p23-like", "go_ids": ["GO:0051879"], "go_terms": ["GO:0051879:Hsp90 protein binding:F"], "name": "p23-like", "pathway_ids": ["R-HSA-3371511", "R-DME-3371497", "R-RNO-3371497", "R-CEL-3371511", "R-HSA-3371497", "R-MMU-8937144", "R-DME-2162123", "R-RNO-9018519", "R-RNO-3371568", "R-CEL-8939211", "R-HSA-8939211", "R-MMU-3371511", "R-SCE-2162123", "R-SPO-2162123", "R-DME-8937144", "R-HSA-3371568", "R-HSA-9018519", "R-HSA-8937144", "R-RNO-8937144", "R-HSA-2162123", "R-MMU-8939211", "R-RNO-2162123", "R-MMU-2162123", "R-DME-9018519", "R-RNO-3371511", "R-HSA-9679191", "R-DME-3371511", "R-MMU-9018519", "R-SCE-8939211", "R-SPO-3371511", "R-DME-3371568", "R-MMU-3371568", "R-CEL-2162123", "R-CEL-8937144", "R-DME-8939211", "R-SCE-3371511", "R-RNO-8939211", "R-MMU-3371497"], "pathways": ["R-HSA-3371511:r:HSF1 activation", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-CEL-3371511:r:HSF1 activation", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-8937144:r:Aryl hydrocarbon receptor signalling", "R-DME-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-RNO-3371568:r:Attenuation phase", "R-CEL-8939211:r:ESR-mediated signaling", "R-HSA-8939211:r:ESR-mediated signaling", "R-MMU-3371511:r:HSF1 activation", "R-SCE-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-SPO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-DME-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-3371568:r:Attenuation phase", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling", "R-RNO-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-8939211:r:ESR-mediated signaling", "R-RNO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-RNO-3371511:r:HSF1 activation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-3371511:r:HSF1 activation", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-SCE-8939211:r:ESR-mediated signaling", "R-SPO-3371511:r:HSF1 activation", "R-DME-3371568:r:Attenuation phase", "R-MMU-3371568:r:Attenuation phase", "R-CEL-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-CEL-8937144:r:Aryl hydrocarbon receptor signalling", "R-DME-8939211:r:ESR-mediated signaling", "R-SCE-3371511:r:HSF1 activation", "R-RNO-8939211:r:ESR-mediated signaling", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "type": "Family"}, "IPR045255": {"description": "Ran binding protein RanBP1-like", "go_ids": [], "go_terms": [], "name": "RanBP1-like", "pathway_ids": ["R-HSA-180910", "R-MMU-2467813", "R-RNO-3301854", "R-MMU-4570464", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-MMU-68877", "R-MMU-159230", "R-HSA-159230", "R-RNO-159230", "R-MMU-4551638", "R-RNO-191859", "R-HSA-3371453", "R-DME-4615885", "R-HSA-4570464", "R-SPO-4085377", "R-HSA-4551638", "R-HSA-9610379", "R-DME-3371453", "R-MMU-141444", "R-SPO-159236", "R-HSA-6784531", "R-MMU-3301854", "R-HSA-141444", "R-DME-159227", "R-HSA-168325", "R-HSA-9648025", "R-MMU-170822", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-RNO-4085377", "R-SPO-4570464", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-MMU-5663220", "R-RNO-4615885", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-191859", "R-HSA-2467813", "R-HSA-3108214", "R-HSA-9705671", "R-SPO-159227", "R-SPO-159231", "R-MMU-3232142", "R-DME-159236", "R-DME-159231", 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{"description": "ArfGAP ACAP1/2/3-like", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "ACAP1/2/3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045260": {"description": "Guanine nucleotide-exchange factor Sec12-like", "go_ids": ["GO:0005085"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "Sec12-like", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-HSA-381038", "R-RNO-5694530", "R-RNO-204005", "R-MMU-5694530", "R-SCE-204005", "R-SPO-204005", "R-HSA-5694530"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-RNO-5694530:r:Cargo concentration in the ER", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-5694530:r:Cargo concentration in the ER", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", 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"Family"}, "IPR045281": {"description": "Zinc finger protein CONSTANS-like", "go_ids": ["GO:0009909"], "go_terms": ["GO:0009909:regulation of flower development:P"], "name": "CONSTANS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045282": {"description": "At4g08330-like", "go_ids": [], "go_terms": [], "name": "At4g08330-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045283": {"description": "Cytokinin-induced F-Box protein AT3G44326-like", "go_ids": [], "go_terms": [], "name": "AT3G44326-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045284": {"description": "At2g27730-like", "go_ids": [], "go_terms": [], "name": "At2g27730-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045285": {"description": "GPI-anchored protein At5g19230-like", "go_ids": [], "go_terms": [], "name": "At5g19230-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045286": {"description": "F-box protein FBS1-like", "go_ids": [], 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"pathways": [], "type": "Family"}, "IPR045315": {"description": "Mitochondrial carrier protein Mtm1-like", "go_ids": ["GO:1990542"], "go_terms": ["GO:1990542:mitochondrial transmembrane transport:P"], "name": "Mtm1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045316": {"description": "Zinc transporter Msc2-like", "go_ids": ["GO:0005385", "GO:0006829", "GO:0006882"], "go_terms": ["GO:0005385:zinc ion transmembrane transporter activity:F", "GO:0006829:zinc ion transport:P", "GO:0006882:intracellular zinc ion homeostasis:P"], "name": "Msc2-like", "pathway_ids": ["R-MMU-435368", "R-SCE-435368", "R-XTR-264876", "R-MMU-264876", "R-DDI-435368", "R-HSA-264876", "R-DRE-264876", "R-SPO-264876", "R-XTR-435368", "R-DDI-264876", "R-DRE-435368", "R-SCE-264876", "R-HSA-435368", "R-SPO-435368"], "pathways": ["R-MMU-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SCE-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-XTR-264876:r:Insulin processing", "R-MMU-264876:r:Insulin processing", "R-DDI-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-HSA-264876:r:Insulin processing", "R-DRE-264876:r:Insulin processing", "R-SPO-264876:r:Insulin processing", "R-XTR-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-DDI-264876:r:Insulin processing", "R-DRE-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SCE-264876:r:Insulin processing", "R-HSA-435368:r:Zinc efflux and compartmentalization by the SLC30 family", "R-SPO-435368:r:Zinc efflux and compartmentalization by the SLC30 family"], "type": "Family"}, "IPR045318": {"description": "Histone-lysine N-methyltransferase EZH1/2-like", "go_ids": ["GO:0042054", "GO:0006338"], "go_terms": ["GO:0042054:histone methyltransferase activity:F", "GO:0006338:chromatin remodeling:P"], "name": "EZH1/2-like", "pathway_ids": ["R-MMU-8953750", "R-HSA-2559580", "R-DRE-2559580", "R-XTR-9764725", "R-DRE-8953750", "R-MMU-212300", "R-HSA-8953750", "R-DME-2559580", "R-CEL-8943724", "R-HSA-3214841", "R-HSA-8943724", "R-DME-9764725", "R-DME-8953750", "R-DRE-212300", "R-DRE-9909649", "R-DME-9909649", "R-BTA-212300", "R-DRE-9764725", "R-MMU-3214841", "R-DME-212300", "R-XTR-212300", "R-HSA-9764725", "R-HSA-9609690", "R-MMU-9764725", "R-MMU-2559580", "R-MMU-8943724", "R-HSA-9710421", "R-XTR-8953750", "R-HSA-212300", "R-HSA-9909649", "R-XTR-9909649", "R-DRE-3214841", "R-MMU-9909649", "R-XTR-2559580", "R-CEL-8953750", "R-DME-8943724", "R-HSA-5617472"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9710421:r:Defective pyroptosis", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "type": "Family"}, "IPR045319": {"description": "Potassium channel KAT/AKT", "go_ids": ["GO:0005249", "GO:0006813"], "go_terms": ["GO:0005249:voltage-gated potassium channel activity:F", "GO:0006813:potassium ion transport:P"], "name": "KAT/AKT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045320": {"description": "Zinc finger protein JAGGED/STAMENLESS 1-like", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "JAGGED/SL1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045322": {"description": "E3 ubiquitin-protein ligase HECTD1/TRIP12-like", "go_ids": ["GO:0061630", "GO:0006511"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F", "GO:0006511:ubiquitin-dependent protein catabolic process:P"], "name": "HECTD1/TRIP12-like", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-DRE-983168", "R-SPO-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR045323": {"description": "Coiled-coil domain-containing protein 34", "go_ids": [], "go_terms": [], "name": "CCDC34", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045324": {"description": "Small multidrug resistance protein", "go_ids": ["GO:0005886", "GO:0022857"], "go_terms": ["GO:0005886:plasma membrane:C", "GO:0022857:transmembrane transporter activity:F"], "name": "Small_multidrug_res", "pathway_ids": ["R-HSA-9913143"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance"], "type": "Family"}, "IPR045325": {"description": "TMEM70/TMEM186/TMEM223 protein family", "go_ids": [], "go_terms": [], "name": "TMEM70/TMEM186/TMEM223", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-DME-6799198", "R-DRE-611105", "R-DRE-6799198", "R-HSA-6799198", "R-BTA-6799198", "R-DME-611105", "R-BTA-611105"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-DME-6799198:r:Complex I biogenesis", "R-DRE-611105:r:Respiratory electron transport", "R-DRE-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Family"}, "IPR045326": {"description": "Autophagy protein ATG17-like domain", "go_ids": [], "go_terms": [], "name": "ATG17-like_dom", "pathway_ids": ["R-SCE-1632852", "R-SPO-1632852"], "pathways": ["R-SCE-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy"], "type": "Domain"}, "IPR045327": {"description": "Protein of unknown function DUF5881", "go_ids": [], "go_terms": [], "name": "DUF5881", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045328": {"description": "Yeast cell wall synthesis Kre9/Knh1", "go_ids": ["GO:0006078", "GO:0042546"], "go_terms": ["GO:0006078:(1->6)-beta-D-glucan biosynthetic process:P", "GO:0042546:cell wall biogenesis:P"], "name": "Kre9/Knh1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045329": {"description": "Leucine zipper putative tumor suppressor", "go_ids": [], "go_terms": [], "name": "LZTS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045330": {"description": "TRM3/TARBP1", "go_ids": [], "go_terms": [], "name": "TRM3/TARBP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045332": {"description": "ARMET, N-terminal", "go_ids": [], "go_terms": [], "name": "ARMET_N", "pathway_ids": ["R-CEL-114608", "R-HSA-114608", "R-BTA-114608", "R-RNO-114608", "R-DME-114608"], "pathways": ["R-CEL-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-DME-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR045333": {"description": "ARMET-like", "go_ids": [], "go_terms": [], "name": "ARMET-like", "pathway_ids": ["R-CEL-114608", "R-HSA-114608", "R-BTA-114608", "R-RNO-114608", "R-DME-114608"], "pathways": ["R-CEL-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-DME-114608:r:Platelet degranulation"], "type": "Family"}, "IPR045334": {"description": "Integrator complex subunit 3", "go_ids": [], "go_terms": [], "name": "INTS3", "pathway_ids": ["R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505", "R-DRE-6807505", "R-DDI-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR045335": {"description": "Cell division protein FtsQ, C-terminal", "go_ids": [], "go_terms": [], "name": "FtsQ_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR045336": {"description": "MmgE/PrpD, N-terminal", "go_ids": [], "go_terms": [], "name": "MmgE_PrpD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045337": {"description": "MmgE/PrpD, C-terminal", "go_ids": [], "go_terms": [], "name": "MmgE_PrpD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045338": {"description": "Domain of unknown function DUF6535", "go_ids": [], "go_terms": [], "name": "DUF6535", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045339": {"description": "Domain of unknown function DUF6534", "go_ids": [], "go_terms": [], "name": "DUF6534", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045340": {"description": "Domain of unknown function DUF6533", "go_ids": [], "go_terms": [], "name": "DUF6533", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045341": {"description": "Domain of unknown function DUF6532", "go_ids": [], "go_terms": [], "name": "DUF6532", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045342": {"description": "Septation protein Etd1", "go_ids": ["GO:0005096", "GO:1902412"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:1902412:regulation of mitotic cytokinesis:P"], "name": "Etd1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045343": {"description": "VpsR domain", "go_ids": [], "go_terms": [], "name": "VpsR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045344": {"description": "C-JID domain", "go_ids": [], "go_terms": [], "name": "C-JID", "pathway_ids": ["PWY-5381"], "pathways": ["PWY-5381:t:NAD salvage (plants)"], "type": "Domain"}, "IPR045345": {"description": "Retroviral nucleocapsid Gag protein p24, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gag_p24_C", "pathway_ids": ["R-HSA-180910", "R-HSA-164516", "R-HSA-162585", "R-HSA-1169408", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-164525", "R-HSA-162594", "R-HSA-162592", "R-HSA-177539", "R-HSA-174490", "R-HSA-175567", "R-HSA-175474", "R-HSA-174495", "R-HSA-173107"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-174495:r:Synthesis And Processing Of GAG, GAGPOL Polyproteins", "R-HSA-173107:r:Binding and entry of HIV virion"], "type": "Domain"}, "IPR045346": {"description": "Ermin", "go_ids": ["GO:0008360", "GO:0007015", "GO:0051015"], "go_terms": ["GO:0008360:regulation of cell shape:P", "GO:0007015:actin filament organization:P", "GO:0051015:actin filament binding:F"], "name": "Ermin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045347": {"description": "HIND motif", "go_ids": ["GO:0000398", "GO:0046540"], "go_terms": ["GO:0000398:mRNA splicing, via spliceosome:P", "GO:0046540:U4/U6 x U5 tri-snRNP complex:C"], "name": "HIND", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Conserved_site"}, "IPR045348": {"description": "CPSF complex subunit CPSF4-like", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "CPSF4/Yth1", "pathway_ids": ["R-HSA-9770562", "R-DME-77595", "R-MMU-9770562", "R-SPO-159231", "R-SCE-77595", "R-XTR-9770562", "R-HSA-6784531", "R-MMU-77595", "R-BTA-73856", "R-HSA-73856", "R-RNO-77595", "R-HSA-168315", "R-HSA-72187", "R-MMU-73856", "R-DME-159231", "R-SPO-77595", "R-HSA-159231", "R-RNO-73856", "R-HSA-77595", "R-DME-9770562", "R-SPO-9770562", "R-MMU-72187", "R-RNO-159231", "R-XTR-77595", "R-RNO-9770562", "R-BTA-9770562", "R-BTA-159231", "R-DME-73856", "R-HSA-9918481", "R-MMU-159231", "R-BTA-77595"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-XTR-9770562:r:mRNA Polyadenylation", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-168315:r:Inhibition of Host mRNA Processing and RNA Silencing", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-XTR-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Family"}, "IPR045349": {"description": "SLC41A divalent cation transporter", "go_ids": ["GO:0008324"], "go_terms": ["GO:0008324:monoatomic cation transmembrane transporter activity:F"], "name": "SLC41A1-3", "pathway_ids": ["R-HSA-425410", "R-MMU-425410", "R-GGA-425410", "R-DRE-425410"], "pathways": ["R-HSA-425410:r:Metal ion SLC transporters", "R-MMU-425410:r:Metal ion SLC transporters", "R-GGA-425410:r:Metal ion SLC transporters", "R-DRE-425410:r:Metal ion SLC transporters"], "type": "Family"}, "IPR045350": {"description": "Protein of unknown function DUF5968", "go_ids": [], "go_terms": [], "name": "DUF5968", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045351": {"description": "Domain of unknown function DUF6531", "go_ids": [], "go_terms": [], "name": "DUF6531", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045352": {"description": "Protein of unknown function DUF6530", "go_ids": [], "go_terms": [], "name": "DUF6530", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045353": {"description": "LAIKA domain", "go_ids": [], "go_terms": [], "name": "LAIKA", "pathway_ids": ["R-HSA-9770562", "R-HSA-9918481", "R-HSA-72163", "R-HSA-3371453"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR045355": {"description": "Poly(A) polymerase catalytic subunit", "go_ids": [], "go_terms": [], "name": "PolyA_pol_cat_su", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045356": {"description": "Protein of unknown function DUF5882", "go_ids": [], "go_terms": [], "name": "DUF5882", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045357": {"description": "Aminopeptidase N-like , N-terminal domain", "go_ids": [], "go_terms": [], "name": "Aminopeptidase_N-like_N", "pathway_ids": ["R-SSC-2022377", "R-HSA-6798695", "R-HSA-2142691", "R-SPO-2142691", "R-CEL-73779", "R-HSA-9018676", "R-SCE-9020265", "R-CEL-6798695", "R-RNO-9023661", "R-BTA-6798695", "R-SCE-9018896", "R-RNO-9020265", "R-CEL-9020265", "R-CEL-9018681", "R-CEL-9023661", "R-SPO-9018896", "R-DDI-9020265", "R-HSA-9023661", "R-HSA-9018896", "R-SCE-2142691", "R-CEL-75953", "R-CEL-73776", "R-RNO-9018676", "R-CEL-76042", "R-MMU-2022377", "R-MMU-9018676", "R-DDI-6798695", "R-BTA-9018896", "R-RNO-1236977", "R-SPO-9020265", "R-MMU-1236977", "R-HSA-2022377", "R-CEL-674695", "R-DDI-9018896", "R-CEL-9018896", "R-HSA-1445148", "R-MMU-983170", "R-MMU-2142691", "R-MMU-6798695", "R-DDI-9018676", "R-RNO-983168", "R-RNO-6798695", "R-RNO-9018896", "R-BTA-9018681", "R-MMU-9018896", "R-SPO-6798695", "R-RNO-983170", "R-HSA-9018681", "R-MMU-9018681", "R-CEL-983170", "R-SCE-6798695", "R-SPO-9018681", "R-CEL-2142691", "R-CEL-983168", "R-MMU-9023661", "R-BTA-9020265", "R-SCE-9023661", "R-DDI-2142691", "R-SPO-983168", "R-SCE-983168", "R-SCE-9018676", "R-BTA-9023661", "R-SCE-983170", "R-CEL-9018676", "R-HSA-9020265", "R-DDI-9018681", "R-RNO-2022377", "R-SPO-9018676", "R-HSA-983168", "R-HSA-1236977", "R-BTA-983170", "R-DDI-9023661", "R-HSA-983170", "R-RNO-2142691", "R-SPO-9023661", "R-MMU-9020265", "R-MMU-983168", "R-RNO-9018681", "R-CFA-6798695", "R-SCE-9018681", "R-BTA-9018676", "R-BTA-2142691"], "pathways": ["R-SSC-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9018676:r:Biosynthesis of D-series resolvins", "R-SCE-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-6798695:r:Neutrophil degranulation", "R-RNO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-BTA-6798695:r:Neutrophil degranulation", "R-SCE-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-RNO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-CEL-9018681:r:Biosynthesis of protectins", "R-CEL-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SPO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-DDI-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-HSA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-9018676:r:Biosynthesis of D-series resolvins", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-9018676:r:Biosynthesis of D-series resolvins", "R-DDI-6798695:r:Neutrophil degranulation", "R-BTA-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-RNO-1236977:r:Endosomal/Vacuolar pathway", "R-SPO-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-CEL-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9018676:r:Biosynthesis of D-series resolvins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-BTA-9018681:r:Biosynthesis of protectins", "R-MMU-9018896:r:Biosynthesis of E-series 18(S)-resolvins", "R-SPO-6798695:r:Neutrophil degranulation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-9018681:r:Biosynthesis of protectins", "R-MMU-9018681:r:Biosynthesis of protectins", "R-CEL-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-6798695:r:Neutrophil degranulation", "R-SPO-9018681:r:Biosynthesis of protectins", "R-CEL-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-BTA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-SCE-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-DDI-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9018676:r:Biosynthesis of D-series resolvins", "R-BTA-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-CEL-9018676:r:Biosynthesis of D-series resolvins", "R-HSA-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-DDI-9018681:r:Biosynthesis of protectins", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-SPO-9018676:r:Biosynthesis of D-series resolvins", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-DDI-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-9023661:r:Biosynthesis of E-series 18(R)-resolvins", "R-MMU-9020265:r:Biosynthesis of aspirin-triggered D-series resolvins", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9018681:r:Biosynthesis of protectins", "R-CFA-6798695:r:Neutrophil degranulation", "R-SCE-9018681:r:Biosynthesis of protectins", "R-BTA-9018676:r:Biosynthesis of D-series resolvins", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "type": "Domain"}, "IPR045358": {"description": "Ty3 transposon capsid-like protein", "go_ids": [], "go_terms": [], "name": "Ty3_capsid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045359": {"description": "Protein of unknown function DUF5903", "go_ids": [], "go_terms": [], "name": "DUF5903", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045360": {"description": "Domain of unknown function DUF5904", "go_ids": [], "go_terms": [], "name": "DUF5904", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045361": {"description": "Contractile injection system tube protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CIS_tube_prot_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045362": {"description": "Contractile injection system spike tip protein", "go_ids": [], "go_terms": [], "name": "CIS_spike_tip", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045363": {"description": "Ceramide kinase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CERK_C", "pathway_ids": ["PWY-5129", "R-HSA-9840309", "R-MMU-9840309"], "pathways": ["PWY-5129:t:sphingolipid biosynthesis (plants)", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis"], "type": "Domain"}, "IPR045364": {"description": "Protein of unknown function DUF5883", "go_ids": [], "go_terms": [], "name": "DUF5883", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045365": {"description": "Protein of unknown function DUF5884", "go_ids": [], "go_terms": [], "name": "DUF5884", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045366": {"description": "Protein of unknown function DUF5905", "go_ids": [], "go_terms": [], "name": "DUF5905", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045367": {"description": "Protein of unknown function DUF5885", "go_ids": [], "go_terms": [], "name": "DUF5885", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045368": {"description": "Protein of unknown function DUF5886", "go_ids": [], "go_terms": [], "name": "DUF5886", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045369": {"description": "Protein of unknown function DUF5887", "go_ids": [], "go_terms": [], "name": "DUF5887", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045370": {"description": "Protein of unknown function DUF5888", "go_ids": [], "go_terms": [], "name": "DUF5888", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045371": {"description": "ADAMTS/ADAMTS-like, cysteine-rich domain 3", "go_ids": [], "go_terms": [], "name": "ADAMTS_CR_3", "pathway_ids": ["R-HSA-1474228", "R-HSA-5083635", "R-RNO-1474228", "R-BTA-5173214", "R-HSA-9845619", "R-HSA-9845621", "R-HSA-1650814", "R-RNO-5173214", "R-HSA-75892", "R-HSA-5173214", "R-MMU-1650814", "R-MMU-5173214", "R-BTA-1650814", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-BTA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR045372": {"description": "YidB-like protein", "go_ids": [], "go_terms": [], "name": "YidB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045373": {"description": "Domain of unknown function DUF5889", "go_ids": [], "go_terms": [], "name": "DUF5889", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045374": {"description": "Cas5fv helical domain", "go_ids": [], "go_terms": [], "name": "Cas5fv_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045375": {"description": "Putative radical SAM, middle domain", "go_ids": [], "go_terms": [], "name": "Put_radical_SAM-like_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045376": {"description": "Glycosyltransferase Maf, N-terminal", "go_ids": [], "go_terms": [], "name": "Maf_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045377": {"description": "Flagellin glycosyltransferase Maf, helical bundle domain", "go_ids": [], "go_terms": [], "name": "Maf_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045378": {"description": "Apolipoprotein N-acyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "LNT_N", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR045379": {"description": "Crinkler effector protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Crinkler_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045380": {"description": "L,D-transpeptidase, scaffold domain", "go_ids": [], "go_terms": [], "name": "LD_TPept_scaffold_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045381": {"description": "Brassinosteroid receptor BRI1, island domain", "go_ids": [], "go_terms": [], "name": "BRI1_island_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045382": {"description": "Protein of unknown function DUF6529", "go_ids": [], "go_terms": [], "name": "DUF6529", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045383": {"description": "Protein of unknown function DUF6528", "go_ids": [], "go_terms": [], "name": "DUF6528", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045384": {"description": "Protein of unknown function DUF6527", "go_ids": [], "go_terms": [], "name": "DUF6527", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045385": {"description": "Protein of unknown function DUF6526", "go_ids": [], "go_terms": [], "name": "DUF6526", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045386": {"description": "Protein of unknown function DUF6525", "go_ids": [], "go_terms": [], "name": "DUF6525", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045387": {"description": "Protein of unknown function DUF6524", "go_ids": [], "go_terms": [], "name": "DUF6524", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045388": {"description": "Protein HHL1-like", "go_ids": [], "go_terms": [], "name": "HHL1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045389": {"description": "Protein of unknown function DUF6522", "go_ids": [], "go_terms": [], "name": "DUF6522", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045390": {"description": "ABC-three component system, Middle Component 3", "go_ids": [], "go_terms": [], "name": "ABC-3C_MC3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045391": {"description": "Protein of unknown function DUF6520", "go_ids": [], "go_terms": [], "name": "DUF6520", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045392": {"description": "Protein of unknown function DUF6519", "go_ids": [], "go_terms": [], "name": "DUF6519", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045393": {"description": "Protein of unknown function DUF6518", "go_ids": [], "go_terms": [], "name": "DUF6518", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045394": {"description": "Alpha/beta hydrolase domain", "go_ids": [], "go_terms": [], "name": "Abhydrolase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045395": {"description": "ALTTAQ repeat", "go_ids": [], "go_terms": [], "name": "ALTTAQ_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR045396": {"description": "Protein of unknown function DUF6517", "go_ids": [], "go_terms": [], "name": "DUF6517", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045397": {"description": "Toxin TumE-like", "go_ids": [], "go_terms": [], "name": "TumE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045398": {"description": "Protein of unknown function DUF6515", "go_ids": [], "go_terms": [], "name": "DUF6515", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045399": {"description": "Trypanosoma Tc-38 (p38) protein", "go_ids": [], "go_terms": [], "name": "Tc-38", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045400": {"description": "Wolframin, cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "Wolframin_Cys-rich", "pathway_ids": ["R-MMU-381426", "R-HSA-8957275", "R-HSA-381038", "R-DME-381426", "R-DME-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR045401": {"description": "GTPase-associated protein 1, middle domain", "go_ids": [], "go_terms": [], "name": "GAP1-M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045402": {"description": "GTPase-associated protein 1, N-terminal domain type 2", "go_ids": [], "go_terms": [], "name": "GAP1-N2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045403": {"description": "Helix-turn-helix domain, Firmicutes-type", "go_ids": [], "go_terms": [], "name": "HTH_59_Firmicutes_type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045404": {"description": "Major capsid protein 13-like", "go_ids": [], "go_terms": [], "name": "Gp13-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045405": {"description": "Capsid maturation protease", "go_ids": [], "go_terms": [], "name": "Capsid_protease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045406": {"description": "Domain of unknown function DUF6513", "go_ids": [], "go_terms": [], "name": "DUF6513", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045407": {"description": "Protein of unknown function DUF6512", "go_ids": [], "go_terms": [], "name": "DUF6512", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045408": {"description": "Protein of unknown function DUF5890", "go_ids": [], "go_terms": [], "name": "DUF5890", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045409": {"description": "Protein of unknown function DUF5891", "go_ids": [], "go_terms": [], "name": "DUF5891", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045410": {"description": "Zinc finger domain-containing protein", "go_ids": [], "go_terms": [], "name": "Zn_finger_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045411": {"description": "Protein of unknown function DUF5892", "go_ids": [], "go_terms": [], "name": "DUF5892", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045412": {"description": "Protein of unknown function DUF5893", "go_ids": [], "go_terms": [], "name": "DUF5893", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045413": {"description": "Domain of unknown function DUF5894", "go_ids": [], "go_terms": [], "name": "DUF5894", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045414": {"description": "Domain of unknown function DUF5895", "go_ids": [], "go_terms": [], "name": "DUF5895", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045415": {"description": "Protein of unknown function DUF5896", "go_ids": [], "go_terms": [], "name": "DUF5896", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045416": {"description": "Domain of unknown function DUF5897", 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"R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-416476:r:G alpha (q) signalling events", "R-GGA-375276:r:Peptide ligand-binding receptors", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Domain"}, "IPR045562": {"description": "ATP-dependent DNA helicase RecG, domain 3, C-terminal", "go_ids": [], "go_terms": [], "name": "RecG_dom3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045563": {"description": "ZSWIM1/3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ZSWIM1/3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045564": {"description": "Protein of unknown function DUF5910", "go_ids": [], "go_terms": [], "name": "DUF5910", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045565": {"description": "Phage capsid protein", "go_ids": [], "go_terms": [], "name": "Phage_capsid_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045566": {"description": "Putative endonuclease SegE-like, GIY-YIG domain", "go_ids": 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"type": "Repeat"}, "IPR045572": {"description": "Type III restriction enzyme, C-terminal endonuclease domain", "go_ids": ["GO:0015668"], "go_terms": ["GO:0015668:type III site-specific deoxyribonuclease activity:F"], "name": "RE_endonuc_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045573": {"description": "Alpha-(1,6)-fucosyltransferase, N- and catalytic domain", "go_ids": [], "go_terms": [], "name": "Fut8_N_cat", "pathway_ids": ["PWY-7426", "R-RNO-975578", "R-MMU-975578", "R-DME-975578", "R-XTR-975578", "R-HSA-975578", "R-HSA-9694548", "R-CEL-975578"], "pathways": ["PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-XTR-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-9694548:r:Maturation of spike protein", "R-CEL-975578:r:Reactions specific to the complex N-glycan synthesis pathway"], "type": "Domain"}, "IPR045574": {"description": "Astrotactin-1/2, Fn3 domain", "go_ids": [], "go_terms": [], "name": "ASTN1_2_Fn3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045575": {"description": "Astrotactin-1/2, N-terminal", "go_ids": [], "go_terms": [], "name": "ASTN_1_2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045576": {"description": "DNA-directed RNA polymerase III subunit RPC5, C-terminal", "go_ids": [], "go_terms": [], "name": "RPC5_C", "pathway_ids": ["R-HSA-76071", "R-HSA-76066", "R-HSA-73980", "R-HSA-76061", "R-MMU-76061", "R-HSA-1834949", "R-MMU-76071", "R-HSA-73780", "R-MMU-76066", "R-HSA-749476"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation"], "type": "Domain"}, "IPR045577": {"description": "Sentrin-specific protease 3/5, conserved domain", "go_ids": [], "go_terms": [], "name": "SENP3_5_cons_dom", "pathway_ids": ["R-MMU-3065679", "R-MMU-6791226", "R-HSA-3065679", "R-HSA-6791226"], "pathways": ["R-MMU-3065679:r:SUMO is proteolytically processed", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-3065679:r:SUMO is proteolytically processed", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR045578": {"description": "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal", "go_ids": [], "go_terms": [], "name": "USP47_C", "pathway_ids": ["R-XTR-5689880", "R-MMU-5689880", "R-HSA-5689880"], "pathways": ["R-XTR-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR045579": {"description": "Acylglycerol kinase, C-terminal", "go_ids": [], "go_terms": [], "name": "AGK_C", "pathway_ids": ["PWY-7039", "PWY-7817", "PWY-5129", "R-MMU-1483206", "R-HSA-6802952", "R-HSA-1483206", "R-DRE-1483206"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-5129:t:sphingolipid biosynthesis (plants)", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-DRE-1483206:r:Glycerophospholipid biosynthesis"], "type": "Domain"}, "IPR045580": {"description": "PIK3 catalytic subunit gamma, adaptor-binding domain", "go_ids": [], "go_terms": [], "name": "PIK3CG_ABD", "pathway_ids": ["PWY-6352", "R-MMU-389357", "R-HSA-9927354", "R-MMU-392451", "R-MMU-9927354", "R-MMU-6811558", "R-MMU-114604", "R-HSA-389357", "R-MMU-9027276", "R-HSA-2219530", "R-HSA-1257604", "R-MMU-1257604", "R-HSA-1660499", "R-HSA-9027276", "R-HSA-392451", "R-MMU-1660499", "R-HSA-114604", "R-HSA-6811558"], "pathways": ["PWY-6352:t:3-phosphoinositide biosynthesis", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9927354:r:Co-stimulation by ICOS", "R-MMU-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-392451:r:G beta:gamma signalling through PI3Kgamma", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "type": "Domain"}, "IPR045581": {"description": "DNA-dependent protein kinase catalytic subunit, CC5", "go_ids": ["GO:0006303"], "go_terms": ["GO:0006303:double-strand break repair via nonhomologous end joining:P"], "name": "DNAPKcs_CC5", "pathway_ids": ["R-HSA-8866654", "R-HSA-3270619", "R-MMU-8866654", "R-HSA-5693571", "R-GGA-353423", "R-DDI-5693571", "R-GGA-351433", "R-HSA-1834949", "R-MMU-5693571"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Domain"}, "IPR045582": {"description": "Trehalase-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Trehalase-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045583": {"description": "Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain", "go_ids": [], 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acid biosynthesis I (B. subtilis)", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1"], "type": "Domain"}, "IPR045588": {"description": "Calsyntenin, C-terminal", "go_ids": [], "go_terms": [], "name": "CLSTN_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045589": {"description": "Protein of unknown function DUF6464", "go_ids": [], "go_terms": [], "name": "DUF6464", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045590": {"description": "Protein of unknown function DUF6463", "go_ids": [], "go_terms": [], "name": "DUF6463", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045591": {"description": "Protein of unknown function DUF6462", "go_ids": [], "go_terms": [], "name": "DUF6462", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045592": {"description": "Protein of unknown function DUF6461", "go_ids": [], "go_terms": [], "name": "DUF6461", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045593": {"description": "Atg11, middle domain", "go_ids": ["GO:0043539"], "go_terms": ["GO:0043539:protein serine/threonine kinase activator activity:F"], "name": "Atg11_middle", "pathway_ids": ["R-SPO-1632852"], "pathways": ["R-SPO-1632852:r:Macroautophagy"], "type": "Domain"}, "IPR045594": {"description": "Domain of unknown function DUF6460", "go_ids": [], "go_terms": [], "name": "DUF6460", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045595": {"description": "SUF system FeS cluster assembly, SufBD, N-terminal", "go_ids": [], "go_terms": [], "name": "SufBD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045596": {"description": "Protein of unknown function DUF6459", "go_ids": [], "go_terms": [], "name": "DUF6459", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045597": {"description": "Domain of unknown function DUF6458", "go_ids": [], "go_terms": [], "name": "DUF6458", "pathway_ids": [], "pathways": [], "type": "Domain"}, 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"type": "Domain"}, "IPR045604": {"description": "Domain of unknown function DUF6453", "go_ids": [], "go_terms": [], "name": "DUF6453", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045605": {"description": "3-ketosteroid-9-alpha-monooxygenase, oxygenase component-like, C-terminal domain", "go_ids": ["GO:0016491", "GO:0008203"], "go_terms": ["GO:0016491:oxidoreductase activity:F", "GO:0008203:cholesterol metabolic process:P"], "name": "KshA-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045606": {"description": "ATXR3, C-terminal", "go_ids": [], "go_terms": [], "name": "ATXR3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045607": {"description": "Protein of unknown function DUF6452", "go_ids": [], "go_terms": [], "name": "DUF6452", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045608": {"description": "Trypsin-co-occurring domain 2", "go_ids": [], "go_terms": [], "name": "Trypco2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045609": {"description": "Domain of unknown function DUF6451", "go_ids": [], "go_terms": [], "name": "DUF6451", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045610": {"description": "Domain of unknown function DUF6450", "go_ids": [], "go_terms": [], "name": "DUF6450", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045611": {"description": "Domain of unknown function DUF6449", "go_ids": [], "go_terms": [], "name": "DUF6449", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045612": {"description": "Domain of unknown function DUF5914", "go_ids": [], "go_terms": [], "name": "DUF5914", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045613": {"description": "Protein of unknown function DUF6448", "go_ids": [], "go_terms": [], "name": "DUF6448", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045614": {"description": "Protein of unknown function DUF6136", "go_ids": [], "go_terms": [], "name": "DUF6136", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045615": {"description": "Protein of unknown function DUF6447", "go_ids": [], "go_terms": [], "name": "DUF6447", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045616": {"description": "Protein of unknown function DUF6446", "go_ids": [], "go_terms": [], "name": "DUF6446", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045617": {"description": "Protein of unknown function DUF6445", "go_ids": [], "go_terms": [], "name": "DUF6445", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045618": {"description": "Domain of unknown function DUF6444", "go_ids": [], "go_terms": [], "name": "DUF6444", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045619": {"description": "Domain of unknown function DUF6443", "go_ids": [], "go_terms": [], "name": "DUF6443", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045620": {"description": "Protein of unknown function DUF6442", "go_ids": [], "go_terms": [], "name": "DUF6442", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045621": {"description": "ABC transporter type 1, GsiC-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BPD_transp_1_N", "pathway_ids": ["R-HSA-9927020", "R-HSA-1222538"], "pathways": ["R-HSA-9927020:r:Heme assimilation", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Domain"}, "IPR045622": {"description": "Protein of unknown function DUF6441", "go_ids": [], "go_terms": [], "name": "DUF6441", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045623": {"description": "LigXa-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LigXa_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045625": {"description": "Protein of unknown function DUF6427", "go_ids": [], "go_terms": [], "name": "DUF6427", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045626": {"description": "D-3-phosphoglycerate dehydrogenase, ASB domain", "go_ids": 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{"description": "Helicase Lhr-like, winged helix domain", "go_ids": [], "go_terms": [], "name": "Lhr_WH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045629": {"description": "Protein of unknown function DUF6232", "go_ids": [], "go_terms": [], "name": "DUF6232", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045630": {"description": "Domain of unknown function DUF6316", "go_ids": [], "go_terms": [], "name": "DUF6316", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045631": {"description": "Protein of unknown function DUF6315", "go_ids": [], "go_terms": [], "name": "DUF6315", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045632": {"description": "Domain of unknown function DUF6314", "go_ids": [], "go_terms": [], "name": "DUF6314", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045633": {"description": "Protein of unknown function DUF6414", "go_ids": [], "go_terms": [], "name": "DUF6414", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045634": {"description": "Protein of unknown function DUF6413", "go_ids": [], "go_terms": [], "name": "DUF6413", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045635": {"description": "Protein of unknown function DUF6412", "go_ids": [], "go_terms": [], "name": "DUF6412", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045636": {"description": "Protein of unknown function DUF6411", "go_ids": [], "go_terms": [], "name": "DUF6411", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045637": {"description": "Protein of unknown function DUF6410", "go_ids": [], "go_terms": [], "name": "DUF6410", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045638": {"description": "Protein of unknown function DUF6409", "go_ids": [], "go_terms": [], "name": "DUF6409", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045639": {"description": "Protein of unknown function DUF6408", "go_ids": [], "go_terms": [], "name": "DUF6408", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045640": {"description": "Protein of unknown function DUF6407", "go_ids": [], "go_terms": [], "name": "DUF6407", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045641": {"description": "Type 2A encapsulin shell protein SrpI-like", "go_ids": [], "go_terms": [], "name": "SrpI-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045642": {"description": "Protein of unknown function DUF6406", "go_ids": [], "go_terms": [], "name": "DUF6406", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045643": {"description": "Protein of unknown function DUF6405", "go_ids": [], "go_terms": [], "name": "DUF6405", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045644": {"description": "Protein of unknown function DUF6404", "go_ids": [], "go_terms": [], "name": "DUF6404", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045645": {"description": "Protein of unknown function DUF6403", "go_ids": [], "go_terms": [], "name": "DUF6403", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045646": {"description": "Protein of unknown function DUF6402", "go_ids": [], "go_terms": [], "name": "DUF6402", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045647": {"description": "Protein of unknown function DUF6401", "go_ids": [], "go_terms": [], "name": "DUF6401", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045648": {"description": "CRISPR-associated protein Cas6-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_Cas6-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045649": {"description": "Protein of unknown function DUF6400", "go_ids": [], "go_terms": [], "name": "DUF6400", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045650": {"description": "Protein of unknown function DUF6399", "go_ids": [], "go_terms": [], "name": "DUF6399", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045651": {"description": "Domain of unknown function DUF6398", "go_ids": [], "go_terms": [], "name": "DUF6398", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045652": {"description": "Protein of unknown function DUF6397", "go_ids": [], "go_terms": [], "name": "DUF6397", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045653": {"description": "Domain of unknown function DUF6396", "go_ids": [], "go_terms": [], "name": "DUF6396", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045654": {"description": "Protein of unknown function DUF6395", "go_ids": [], "go_terms": [], "name": "DUF6395", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045655": {"description": "Protein of unknown function DUF6394", "go_ids": [], "go_terms": [], "name": "DUF6394", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045656": {"description": "Protein of unknown function DUF6393", "go_ids": [], "go_terms": [], "name": "DUF6393", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045657": {"description": "Immunity protein CdiI, Gammaproteobacteria-type", "go_ids": [], "go_terms": [], "name": "CdiI_gamma-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045658": {"description": "FRAS1-related extracellular matrix protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FRAS1-rel_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045659": {"description": "LPS-assembly protein LptD, central domain", "go_ids": [], "go_terms": [], "name": "LptD_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045660": {"description": "Protein of unknown function DUF6390", "go_ids": [], "go_terms": [], "name": "DUF6390", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045661": {"description": "Protein of unknown function DUF6389", "go_ids": [], "go_terms": [], "name": "DUF6389", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045662": {"description": "Protein of unknown function DUF6388", "go_ids": [], "go_terms": [], "name": "DUF6388", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045663": {"description": "Origin recognition complex subunit 3, insertion domain", "go_ids": [], "go_terms": [], "name": "ORC3_ins", "pathway_ids": ["R-RNO-68949", "R-HSA-68616", "R-HSA-68949", "R-RNO-68962", "R-RNO-68616", "R-MMU-68962", "R-HSA-113507", "R-MMU-176187", "R-HSA-68962", "R-MMU-68689", "R-MMU-68949", "R-RNO-176187", "R-MMU-68616", "R-HSA-68689", "R-HSA-176187", "R-RNO-68689", "R-HSA-68867"], "pathways": ["R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68949:r:Orc1 removal from chromatin", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR045664": {"description": "Protein of unknown function DUF6387", "go_ids": [], "go_terms": [], "name": "DUF6387", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045665": {"description": "Protein of unknown function DUF6386", "go_ids": [], "go_terms": [], "name": "DUF6386", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045666": {"description": "Oligopeptidase A, N-terminal domain", "go_ids": [], "go_terms": [], "name": "OpdA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045667": {"description": "Origin recognition complex subunit 3, N-terminal", "go_ids": [], "go_terms": [], "name": "ORC3_N", "pathway_ids": ["R-DDI-68689", "R-RNO-68949", "R-SPO-176187", "R-HSA-68949", "R-SPO-68616", "R-RNO-68962", "R-MMU-68962", "R-HSA-113507", "R-HSA-68867", "R-MMU-68949", "R-RNO-176187", "R-HSA-68689", "R-SCE-68962", "R-SCE-68616", "R-HSA-68616", "R-RNO-68616", "R-DDI-68962", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949", "R-SCE-176187", "R-HSA-176187", "R-RNO-68689", "R-DDI-68616"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication"], "type": "Domain"}, "IPR045668": {"description": "FHF complex subunit HOOK-interacting protein, KELAA motif", "go_ids": [], "go_terms": [], "name": "FHIP_KELAA_motif", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR045669": {"description": "FHF complex subunit HOOK-interacting protein, C-terminal", "go_ids": [], "go_terms": [], "name": "FHIP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045670": {"description": "Domain of unknown function DUF5916", "go_ids": [], "go_terms": [], "name": "DUF5916", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045671": {"description": "Nitrogen regulation protein NtrY-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NtrY-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045672": {"description": "Mesaconyl-CoA hydratase, archaea", "go_ids": [], "go_terms": [], "name": "MC_hydratase_acr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045673": {"description": "Phenol-soluble modulin delta protein", "go_ids": [], "go_terms": [], "name": "PSM_delta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045674": {"description": "Protein of unknown function DUF6196", "go_ids": [], "go_terms": [], "name": "DUF6196", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045675": {"description": "Protein of unknown function DUF6195", "go_ids": [], "go_terms": [], "name": "DUF6195", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045676": {"description": "Domain of unknown function DUF6194", "go_ids": [], "go_terms": [], "name": "DUF6194", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045677": {"description": "Protein of unknown function DUF6197", "go_ids": [], "go_terms": [], "name": "DUF6197", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045679": {"description": "Domain of unknown function DUF6199", "go_ids": [], "go_terms": [], "name": "DUF6199", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045680": {"description": "Protein of unknown function DUF6200", "go_ids": [], "go_terms": [], "name": "DUF6200", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045681": {"description": "Protein of unknown function DUF6201", "go_ids": [], "go_terms": [], "name": "DUF6201", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045682": {"description": "Protein of unknown function DUF6193", "go_ids": [], "go_terms": [], "name": "DUF6193", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045683": {"description": "Protein of unknown function DUF6192", "go_ids": [], "go_terms": [], "name": "DUF6192", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045684": {"description": "Protein of unknown function DUF6191", "go_ids": [], "go_terms": [], "name": "DUF6191", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045685": {"description": "Protein of unknown function DUF6190", "go_ids": [], "go_terms": [], "name": "DUF6190", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045686": {"description": "Protein of unknown function DUF6189", "go_ids": [], "go_terms": [], "name": "DUF6189", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045687": {"description": "GPI ethanolamine phosphate transferase 2, C-terminal", "go_ids": [], "go_terms": [], "name": "PIGG/GPI7_C", "pathway_ids": ["R-SCE-162710", "R-HSA-162710"], "pathways": ["R-SCE-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)", "R-HSA-162710:r:Synthesis of glycosylphosphatidylinositol (GPI)"], "type": "Domain"}, "IPR045688": {"description": "Ets1, N-terminal flanking region of Ets domain", "go_ids": [], "go_terms": [], "name": "Ets1_N_flank", "pathway_ids": ["R-GGA-2559585", "R-MMU-2559585", "R-BTA-2559585", "R-RNO-2559585", "R-HSA-2559585"], "pathways": ["R-GGA-2559585:r:Oncogene Induced Senescence", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-HSA-2559585:r:Oncogene Induced Senescence"], "type": "Domain"}, "IPR045689": {"description": "S-layer protein Slr4", "go_ids": [], "go_terms": [], "name": "Slr4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045690": {"description": "Domain of unknown function DUF6055", "go_ids": [], "go_terms": [], "name": "DUF6055", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045691": {"description": "STM0557-like", "go_ids": [], "go_terms": [], "name": "STM0557-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045692": {"description": "Protein of unknown function DUF6057", "go_ids": [], "go_terms": [], "name": "DUF6057", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045693": {"description": "NAD(P)H-quinone oxidoreductase subunit 2, N-terminal", "go_ids": [], "go_terms": [], "name": "Ndh2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045694": {"description": "Protein of unknown function DUF6058", "go_ids": [], "go_terms": [], "name": "DUF6058", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045695": {"description": "Transmembrane protein 131-like, second Ig-like domain", "go_ids": [], "go_terms": [], "name": "TMEM131-like_Ig_dom2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045696": {"description": "RING finger protein 37, N-terminal", "go_ids": [], "go_terms": [], "name": "Ubox5_N", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR045697": {"description": "Domain of unknown function DUF5919", "go_ids": [], "go_terms": [], "name": "DUF5919", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045698": {"description": "Rab3GAP catalytic subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "Rab3GAP1_C", "pathway_ids": ["R-RNO-6811436", "R-RNO-8876198", "R-HSA-8876198", "R-MMU-8876198", "R-HSA-6811436", "R-MMU-6811436"], "pathways": ["R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR045699": {"description": "Galactofuranosyltransferase-2, C-terminal", "go_ids": [], "go_terms": [], "name": "GlfT2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045700": {"description": "Rab3GAP catalytic subunit", "go_ids": ["GO:0005096", "GO:0043547"], "go_terms": ["GO:0005096:GTPase activator activity:F", "GO:0043547:positive regulation of GTPase activity:P"], "name": "Rab3GAP1", "pathway_ids": ["R-RNO-6811436", "R-MMU-8876198", "R-CEL-8876198", "R-DME-6811436", "R-DME-8876198", "R-CEL-6811436", "R-RNO-8876198", "R-HSA-8876198", "R-HSA-6811436", "R-MMU-6811436"], "pathways": ["R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR045701": {"description": "Protein of unknown function DUF6059", "go_ids": [], "go_terms": [], "name": "DUF6059", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045702": {"description": "Domain of unknown function DUF6060", "go_ids": [], "go_terms": [], "name": "DUF6060", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045703": {"description": "POU domain, class 2, transcription factor 1, C-terminal", "go_ids": [], "go_terms": [], "name": "POU2F1_C", "pathway_ids": ["R-HSA-76071", "R-HSA-6807505", "R-RNO-6807505", "R-RNO-76071", "R-MMU-76071", "R-HSA-749476", "R-HSA-6785807", "R-XTR-6807505", "R-RNO-9018519", "R-HSA-9018519", "R-MMU-6807505"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR045704": {"description": "BTB/POZ domain-containing protein KCTD18, C-terminal domain", "go_ids": [], "go_terms": [], "name": "KCTD18_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045705": {"description": "Protein of unknown function DUF6061", "go_ids": [], "go_terms": [], "name": "DUF6061", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045706": {"description": "Protein of unknown function DUF6062", "go_ids": [], "go_terms": [], "name": "DUF6062", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045707": {"description": "Protein of unknown function DUF6063", "go_ids": [], "go_terms": [], "name": "DUF6063", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045708": {"description": "Protein of unknown function DUF6064", "go_ids": [], "go_terms": [], "name": "DUF6064", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045709": {"description": "Protein of unknown function DUF6065", "go_ids": [], "go_terms": [], "name": "DUF6065", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045710": {"description": "Protein of unknown function DUF6066", "go_ids": [], "go_terms": [], "name": "DUF6066", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045711": {"description": "Glycoside hydrolase 123-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GH123-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045712": {"description": "Protein of unknown function DUF6068", "go_ids": [], "go_terms": [], "name": "DUF6068", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045713": {"description": "Protein of unknown function DUF6069", "go_ids": [], "go_terms": [], "name": "DUF6069", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045714": {"description": "Protein of unknown function DUF6070", "go_ids": [], "go_terms": [], "name": "DUF6070", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045715": {"description": "Protein of unknown function DUF6071", "go_ids": [], "go_terms": [], "name": "DUF6071", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045716": {"description": "Chordin-like protein 1/2, C-terminal", "go_ids": [], "go_terms": [], "name": "CHRDL_1/2_C", "pathway_ids": ["R-RNO-381426", "R-RNO-8957275", "R-MMU-381426", "R-GGA-201451", "R-GGA-8957275", "R-MMU-201451", "R-HSA-201451", "R-HSA-8957275", "R-RNO-201451", "R-GGA-381426", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-201451:r:Signaling by BMP", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-MMU-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-201451:r:Signaling by BMP", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR045717": {"description": "Chordin-like protein 1/2", "go_ids": [], "go_terms": [], "name": "CHRDL1/2", "pathway_ids": ["R-RNO-381426", "R-RNO-8957275", "R-MMU-381426", "R-GGA-201451", "R-GGA-8957275", "R-MMU-201451", "R-HSA-201451", "R-HSA-8957275", "R-RNO-201451", "R-GGA-381426", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-201451:r:Signaling by BMP", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-MMU-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-201451:r:Signaling by BMP", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR045718": {"description": "Protein of unknown function DUF6072", "go_ids": [], "go_terms": [], "name": "DUF6072", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045719": {"description": "Protein of unknown function DUF6073", "go_ids": [], "go_terms": [], "name": "DUF6073", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045720": {"description": "Protein of unknown function DUF6074", "go_ids": [], "go_terms": [], "name": "DUF6074", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045721": {"description": "Protein of unknown function DUF6075", "go_ids": [], "go_terms": [], "name": "DUF6075", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045722": {"description": "Protein of unknown function DUF6076", "go_ids": [], "go_terms": [], "name": "DUF6076", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045723": {"description": "Protein of unknown function DUF6077", "go_ids": [], "go_terms": [], "name": "DUF6077", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045724": {"description": "Protein of unknown function DUF6078", "go_ids": [], "go_terms": [], "name": "DUF6078", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045725": {"description": "BrxC/PglY, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BrxC/PglY_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045726": {"description": "Protein of unknown function DUF6080", "go_ids": [], "go_terms": [], "name": "DUF6080", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045727": {"description": "Protein of unknown function DUF6081", "go_ids": [], "go_terms": [], "name": "DUF6081", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045728": {"description": "Protein of unknown function DUF6082", "go_ids": [], "go_terms": [], "name": "DUF6082", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045729": {"description": "Protein of unknown function DUF6083", "go_ids": [], "go_terms": [], "name": "DUF6083", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045730": {"description": "Protein of unknown function DUF6084", "go_ids": [], "go_terms": [], "name": "DUF6084", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045731": {"description": "Protein of unknown function DUF6085", "go_ids": [], "go_terms": [], "name": "DUF6085", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045732": {"description": "Protein of unknown function DUF6086", "go_ids": [], "go_terms": [], "name": "DUF6086", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045733": {"description": "Protein of unknown function DUF6087", "go_ids": [], "go_terms": [], "name": "DUF6087", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045734": {"description": "Sorting nexin 8/Mvp1, BAR domain", "go_ids": [], "go_terms": [], "name": "Snx8_BAR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045735": {"description": "Stage III sporulation protein AA, AAA+ ATPase domain", "go_ids": [], "go_terms": [], "name": "Spore_III_AA_AAA+_ATPase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045736": {"description": "START-like domain", "go_ids": [], "go_terms": [], "name": "START_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045737": {"description": "E3 ubiquitin-protein ligase RKP, N-terminal", "go_ids": [], "go_terms": [], "name": "RKP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045738": {"description": "Protein of unknown function DUF6088", "go_ids": [], "go_terms": [], "name": "DUF6088", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045739": {"description": "ACT domain pair", "go_ids": [], "go_terms": [], "name": "ACT_dom_pair", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045740": {"description": "BTB/POZ domain-containing protein KCTD4, C-terminal", "go_ids": [], "go_terms": [], "name": "KCTD4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045741": {"description": "Type IX secretion system protein PorV", "go_ids": [], "go_terms": [], "name": "PorV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045742": {"description": "LETM2, N-terminal", "go_ids": [], "go_terms": [], "name": "LETM2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045743": {"description": "Domain of unknown function DUF6089", "go_ids": [], "go_terms": [], "name": "DUF6089", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045744": {"description": "E3 ubiquitin-protein ligase RNF152, C-terminal", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "RNF152_C", "pathway_ids": ["PWY-7511", "R-MMU-8866654", "R-HSA-8866654", "R-GGA-8866654", "R-RNO-8866654", "R-DRE-8866654"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-GGA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DRE-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Domain"}, "IPR045745": {"description": "Helix-turn-helix domain, Actinobacteria-type", "go_ids": [], "go_terms": [], "name": "HTH_58_Actinobacteria-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045746": {"description": "Putative acyltransferase ACT14924-like, acyltransferase domain", "go_ids": [], "go_terms": [], "name": "ACT14924-like_Acyltransf_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045747": {"description": "CRISPR-associated protein Cas6, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "CRISPR-assoc_prot_Cas6_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR045748": {"description": "DcaP outer membrane protein", "go_ids": [], "go_terms": [], "name": "DcaP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045749": {"description": "Protein of unknown function DUF6090", "go_ids": [], "go_terms": [], "name": "DUF6090", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045750": {"description": "Protein of unknown function DUF6178", "go_ids": [], "go_terms": [], "name": "DUF6178", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045751": {"description": "Protein of unknown function DUF6179", "go_ids": [], "go_terms": [], "name": "DUF6179", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045752": {"description": "Protein of unknown function DUF6180", "go_ids": [], "go_terms": [], "name": "DUF6180", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045753": {"description": "Protein of unknown function DUF6181", "go_ids": [], "go_terms": [], "name": "DUF6181", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045754": {"description": "Protein of unknown function DUF6182", "go_ids": [], "go_terms": [], "name": "DUF6182", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045755": {"description": "Bacteriodetes cell division protein FtsL-like", "go_ids": [], "go_terms": [], "name": "FtsL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045756": {"description": "Protein of unknown function DUF6183", "go_ids": [], "go_terms": [], "name": "DUF6183", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045757": {"description": "Protein of unknown function DUF6184", "go_ids": [], "go_terms": [], "name": "DUF6184", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045758": {"description": "Solute-binding protein AdeT 1/2", "go_ids": [], "go_terms": [], "name": "AdeT1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045759": {"description": "Ap4A phosphorylase 1/2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ap4A_phos1/2_N", "pathway_ids": ["PWY-5279"], "pathways": ["PWY-5279:t:sulfite oxidation II"], "type": "Domain"}, "IPR045760": {"description": "2,4-diaminopentanoate dehydrogenase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DAP_DH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045761": {"description": "ODP domain", "go_ids": [], "go_terms": [], "name": "ODP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045762": {"description": "ADNP, zinc finger domain", "go_ids": [], "go_terms": [], "name": "ADNP_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045763": {"description": "BTB/POZ domain-containing protein KCTD11/21, C-terminal domain", "go_ids": [], "go_terms": [], "name": "KCTD11/21_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045764": {"description": "Protein of unknown function DUF6132", "go_ids": [], "go_terms": [], "name": "DUF6132", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045765": {"description": "Protein of unknown function DUF6133", "go_ids": [], "go_terms": [], "name": "DUF6133", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045766": {"description": "MCAfunc domain", "go_ids": [], "go_terms": [], "name": "MCAfunc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045767": {"description": "Protein of unknown function DUF6134", "go_ids": [], "go_terms": [], "name": "DUF6134", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045768": {"description": "Stage II sporulation protein E, N-terminal", "go_ids": [], "go_terms": [], "name": "SpoIIE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045769": {"description": "Delta and Notch-like epidermal growth factor-related receptor, C-terminal", "go_ids": [], "go_terms": [], "name": "DNER_C", "pathway_ids": ["R-HSA-2122948"], "pathways": ["R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus"], "type": "Domain"}, "IPR045770": {"description": "Protein of unknown function DUF6223", "go_ids": [], "go_terms": [], "name": "DUF6223", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045771": {"description": "Protein of unknown function DUF6224", "go_ids": [], "go_terms": [], "name": "DUF6224", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045772": {"description": "Protein of unknown function DUF6225", "go_ids": [], "go_terms": [], "name": "DUF6225", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045773": {"description": "Protein of unknown function DUF6226", "go_ids": [], "go_terms": [], "name": "DUF6226", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045774": {"description": "Methylcrotonoyl-CoA carboxylase subunit alpha, BT domain", "go_ids": [], "go_terms": [], "name": "MCCA_BT_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045775": {"description": "Protein of unknown function DUF6207", "go_ids": [], "go_terms": [], "name": "DUF6207", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045776": {"description": "Protein of unknown function DUF6202", "go_ids": [], "go_terms": [], "name": "DUF6202", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045777": {"description": "Protein of unknown function DUF6203", "go_ids": [], "go_terms": [], "name": "DUF6203", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045778": {"description": "Protein of unknown function DUF6204", "go_ids": [], "go_terms": [], "name": "DUF6204", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045779": {"description": "Protein of unknown function DUF6205", "go_ids": [], "go_terms": [], "name": "DUF6205", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045780": {"description": "Protein of unknown function DUF6206", "go_ids": [], "go_terms": [], "name": "DUF6206", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045781": {"description": "Saxitoxin biosynthesis operon protein SxtJ", "go_ids": [], "go_terms": [], "name": "SxtJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045782": {"description": "TrbL/VirB6 plasmid conjugal transfer like protein", "go_ids": [], "go_terms": [], "name": "TrbL_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045784": {"description": "Radical SAM domain-containing protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Radical_SAM_N2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045785": {"description": "Dipeptidyl peptidase 8 /9 ,N-terminal", "go_ids": [], "go_terms": [], "name": "Dpp_8/9_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045786": {"description": "Rho GTPase-activating protein, pG1 and pG2 domain", "go_ids": [], "go_terms": [], "name": "RhoGAP_pG1_pG2", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9013405", "R-CFA-9013409", "R-HSA-416550", "R-MMU-9013106", "R-RNO-9013409", "R-RNO-9696270", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9013409", "R-CFA-9013404", "R-MMU-9013148", "R-HSA-9013106", "R-MMU-9013404", "R-RNO-416550", "R-CFA-9013149", "R-HSA-8849471", "R-HSA-9013423", "R-CFA-8849471", "R-DME-9035034", "R-DME-9013148", "R-CFA-9696264", "R-CFA-9013408", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013409", "R-DME-9013406", "R-RNO-9013408", "R-RNO-9013106", "R-RNO-9013406", "R-RNO-9013404", "R-CFA-9696270", "R-HSA-9013408", "R-MMU-8849471", "R-DME-350407", "R-MMU-9035034", "R-RNO-8849471", "R-CFA-9013406", "R-CFA-9013148", "R-DME-9013149", "R-CFA-8980692", "R-DME-8980692", "R-HSA-9696270", "R-CFA-416550", "R-RNO-9013148", "R-RNO-9696273", "R-CFA-9696273", "R-HSA-9696264", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-416550", "R-CFA-9013106", "R-MMU-9013406", "R-MMU-9013026", "R-RNO-9696264", "R-HSA-9013026", "R-DME-8849471", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9013149", "R-DME-9013423", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-CFA-9013409:r:RHOJ GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-9035034:r:RHOF GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-CFA-9696264:r:RND3 GTPase cycle", "R-CFA-9013408:r:RHOG GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-CFA-9696270:r:RND2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-350407:r:RHO1 GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CFA-8980692:r:RHOA GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-CFA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR045787": {"description": "Mesoderm induction early response protein 1/3, C-terminal", "go_ids": [], "go_terms": [], "name": "MIER1/3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045788": {"description": "MobC-like protein", "go_ids": [], "go_terms": [], "name": "MobC_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045789": {"description": "Protein inscuteable homologue, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Insc_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045790": {"description": "E3 ubiquitin-protein ligase RNF180, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RNF180_C", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR045791": {"description": "Semaphorin 4F, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Sema4F_C", "pathway_ids": ["R-MMU-9696264", "R-HSA-9696264", "R-RNO-9696264"], "pathways": ["R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR045792": {"description": "Domain of unknown function DUF6036", "go_ids": [], "go_terms": [], "name": "DUF6036", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045793": {"description": "PcRGLX/YetA-like", "go_ids": [], "go_terms": [], "name": "PcRGLX/YetA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045794": {"description": "Trypsin-co-occurring domain 1", "go_ids": [], "go_terms": [], "name": "Trypco1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045795": {"description": "Transglycosylase, SLT domain", "go_ids": [], "go_terms": [], "name": "SLT_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045796": {"description": "Failed axon connections homolog, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FAXC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045797": {"description": "Evasins Class A", "go_ids": ["GO:0019957", "GO:1900137"], "go_terms": ["GO:0019957:C-C chemokine binding:F", "GO:1900137:negative regulation of chemokine activity:P"], "name": "EVA_Class_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045798": {"description": "TrbL/VirB6 plasmid conjugal transfer like protein, Firmicutes", "go_ids": [], "go_terms": [], "name": "TrbL_Firmicutes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045799": {"description": "TBC1 domain family member 23, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TBC1D23_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045800": {"description": "Heavy metal binding domain", "go_ids": ["GO:0046872"], "go_terms": ["GO:0046872:metal ion binding:F"], "name": "HMBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045801": {"description": "Mitogen-activated protein kinase kinase kinase, N-terminal", "go_ids": ["GO:0000165"], "go_terms": ["GO:0000165:MAPK cascade:P"], "name": "MEKK4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045802": {"description": "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GRV2/DNAJC13_N", "pathway_ids": ["R-HSA-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR045803": {"description": "Domain of unknown function DUF5921", "go_ids": [], "go_terms": [], "name": "DUF5921", "pathway_ids": ["R-MMU-76066", "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-MMU-76061"], "pathways": ["R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR045804": {"description": "Domain of unknown function DUF5920", "go_ids": [], "go_terms": [], "name": "DUF5920", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045805": {"description": "Protein NDNF, C-terminal", "go_ids": [], "go_terms": [], "name": "NDNF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045806": {"description": "BMP and activin membrane-bound inhibitor, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BAMBI_C", "pathway_ids": ["R-HSA-2173788", "R-RNO-2173788", "R-MMU-2173788"], "pathways": ["R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling"], "type": "Domain"}, "IPR045807": {"description": "BMP and activin membrane-bound inhibitor, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BAMBI_N", "pathway_ids": ["R-HSA-2173788", "R-RNO-2173788", "R-MMU-2173788"], "pathways": ["R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling"], "type": "Domain"}, "IPR045809": {"description": "MobI protein", "go_ids": [], "go_terms": [], "name": "MobI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045810": {"description": "eIF3h, C-terminal", "go_ids": [], "go_terms": [], "name": "eIF3h_C", "pathway_ids": ["R-CEL-72689", "R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-CEL-72695", "R-HSA-156827", "R-GGA-72702", "R-XTR-72702", "R-RNO-72689", "R-MMU-72649", "R-HSA-72695", "R-BTA-72689", "R-RNO-72695", "R-MMU-72706", "R-SPO-72689", "R-BTA-72695", "R-XTR-72695", "R-MMU-72695", "R-DRE-156827", "R-DME-72695", "R-BTA-156827", "R-MMU-72702", "R-RNO-156827", "R-DRE-72695", "R-SPO-72706", "R-SPO-72649", "R-DDI-72695", "R-SPO-72695", "R-XTR-156827", "R-BTA-72702", "R-DME-72689", "R-HSA-72706", "R-RNO-72702", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-CEL-156827", "R-RNO-72649", "R-DRE-72649", "R-GGA-72649", "R-DRE-72702", "R-DRE-72689", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-BTA-72649", "R-GGA-72695", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": ["R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-GGA-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-BTA-72649:r:Translation initiation complex formation", "R-GGA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Domain"}, "IPR045811": {"description": "MTP large subunit, lipid-binding domain", "go_ids": ["GO:0008289"], "go_terms": ["GO:0008289:lipid binding:F"], "name": "MTP_lip-bd", "pathway_ids": ["R-RNO-8963888", "R-MMU-8866423", "R-SSC-8963888", "R-MMU-8963888", "R-MMU-8964041", "R-HSA-8866423", "R-RNO-8866423", "R-RNO-8964041", "R-SSC-8866423", "R-DME-8964041", "R-HSA-8963888", "R-HSA-8964041", "R-CEL-8964041", "R-SSC-8964041", "R-DRE-8964041"], "pathways": ["R-RNO-8963888:r:Chylomicron assembly", "R-MMU-8866423:r:VLDL assembly", "R-SSC-8963888:r:Chylomicron assembly", "R-MMU-8963888:r:Chylomicron assembly", "R-MMU-8964041:r:LDL remodeling", "R-HSA-8866423:r:VLDL assembly", "R-RNO-8866423:r:VLDL assembly", "R-RNO-8964041:r:LDL remodeling", "R-SSC-8866423:r:VLDL assembly", "R-DME-8964041:r:LDL remodeling", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-CEL-8964041:r:LDL remodeling", "R-SSC-8964041:r:LDL remodeling", "R-DRE-8964041:r:LDL remodeling"], "type": "Domain"}, "IPR045812": {"description": "DAHL domain", "go_ids": [], "go_terms": [], "name": "DAHL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045813": {"description": "Cysteine-rich motor neuron 1 protein, C-terminal", "go_ids": [], "go_terms": [], "name": "CRIM1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045814": {"description": "Integrator complex subunit 14, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "IntS14_b-barrel", "pathway_ids": ["R-DME-6807505", "R-HSA-6807505", "R-GGA-6807505", "R-RNO-6807505", "R-BTA-6807505", "R-MMU-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR045815": {"description": "Neutrophin-3, N-terminal", "go_ids": [], "go_terms": [], "name": "NTF3_N", "pathway_ids": ["R-BTA-9603381", "R-MMU-9603381", "R-BTA-9034013", "R-HSA-9034015", "R-MMU-6811558", "R-RNO-9034793", "R-RNO-9603381", "R-HSA-9034793", "R-RNO-1257604", "R-HSA-9034864", "R-MMU-1257604", "R-HSA-2219530", "R-MMU-9034793", "R-HSA-6811558", "R-HSA-9034013", "R-RNO-6811558", "R-BTA-6811558", "R-HSA-9603381", "R-BTA-1257604", "R-RNO-9034013", "R-HSA-1257604", "R-MMU-9034013", "R-BTA-9034793", "R-HSA-9025046"], "pathways": ["R-BTA-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-BTA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9034015:r:Signaling by NTRK3 (TRKC)", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-RNO-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-BTA-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling"], "type": "Domain"}, "IPR045816": {"description": "Protein angel homolog 2, N-terminal", "go_ids": [], "go_terms": [], "name": "ANGEL2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045817": {"description": "Dynamin-like GTPase OPA1, C-terminal", "go_ids": [], "go_terms": [], "name": "OPA1_C", "pathway_ids": ["R-HSA-9837999", "R-DRE-169911", "R-RNO-169911", "R-MMU-169911", "R-HSA-169911"], "pathways": ["R-HSA-9837999:r:Mitochondrial protein degradation", "R-DRE-169911:r:Regulation of Apoptosis", "R-RNO-169911:r:Regulation of Apoptosis", "R-MMU-169911:r:Regulation of Apoptosis", "R-HSA-169911:r:Regulation of Apoptosis"], "type": "Domain"}, "IPR045818": {"description": "Gamma-tubulin complex component 6, N-terminal", "go_ids": [], "go_terms": [], "name": "GCP6_N", "pathway_ids": ["R-HSA-380320", "R-MMU-380270", "R-MMU-380320", "R-HSA-380270"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR045819": {"description": "Tetratricopeptide repeat protein 7, N-terminal", "go_ids": [], "go_terms": [], "name": "TTC7_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045820": {"description": "CLEC16A, C-terminal", "go_ids": [], "go_terms": [], "name": "CLEC16A_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045821": {"description": "Beta-1,3-galactosyltransferase 2, N-terminal", "go_ids": [], "go_terms": [], "name": "B3GT2_N", "pathway_ids": ["PWY-7839", "PWY-7832", "PWY-7833", "PWY-7920", "PWY-8459", "R-HSA-9037629", "R-MMU-9037629"], "pathways": ["PWY-7839:t:lacto-series glycosphingolipids biosynthesis", "PWY-7832:t:ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide", "PWY-7833:t:biosynthesis of Lewis epitopes (H. pylori)", "PWY-7920:t:complex N-linked glycan biosynthesis (plants)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-MMU-9037629:r:Lewis blood group biosynthesis"], "type": "Domain"}, "IPR045822": {"description": "CO dehydrogenase/acetyl-CoA synthase complex beta subunit , C-terminal", "go_ids": [], "go_terms": [], "name": "ACS_CODH_B_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045823": {"description": "Tetracyclin repressor-like MT0489/Rv0472c, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_C_32", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045824": {"description": "Type II secretion system protein TadB-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "T2SS_TadB-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045825": {"description": "Lanthionine-containing peptide SapB precursor RamS", "go_ids": [], "go_terms": [], "name": "RamS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045826": {"description": "SpaA-like, prealbumin fold domain subgroup 2", "go_ids": [], "go_terms": [], "name": "SpaA_PFL_dom_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045827": {"description": "Deubiquitinating protein VCPIP1, N-terminal", "go_ids": [], "go_terms": [], "name": "VCPIP1_N", "pathway_ids": ["R-MMU-5689896", "R-HSA-5689896", "R-RNO-5689896"], "pathways": ["R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-RNO-5689896:r:Ovarian tumor domain proteases"], "type": "Domain"}, "IPR045828": {"description": "PKD-like domain, Bacteroidetes", "go_ids": [], "go_terms": [], "name": "PKD_Bacteroidetes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045829": {"description": "PKD-like domain", "go_ids": [], "go_terms": [], "name": "PKD_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045830": {"description": "AraR-like, winged helix DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "AraR_wHTH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045831": {"description": "LIN-9, C-terminal", "go_ids": [], "go_terms": [], "name": "LIN9_C", "pathway_ids": ["R-MMU-1538133", "R-HSA-69656", "R-CEL-1538133", "R-HSA-1362277", "R-HSA-69205", "R-HSA-1362300", "R-HSA-156711", "R-DRE-1538133", "R-HSA-1538133", "R-HSA-69202"], "pathways": ["R-MMU-1538133:r:G0 and Early G1", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-1538133:r:G0 and Early G1", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-69205:r:G1/S-Specific Transcription", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-HSA-156711:r:Polo-like kinase mediated events", "R-DRE-1538133:r:G0 and Early G1", "R-HSA-1538133:r:G0 and Early G1", "R-HSA-69202:r:Cyclin E associated events during G1/S transition"], "type": "Domain"}, "IPR045832": {"description": "Cell cycle link protein Clink", "go_ids": [], "go_terms": [], "name": "Clink", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045833": {"description": "Astrovirus p19 protein", "go_ids": [], "go_terms": [], "name": "Astro_p19", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR045834": {"description": "Csd3-like, second N-terminal domain", "go_ids": [], "go_terms": [], "name": "Csd3_N2", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR045835": {"description": "Astrovirus transmembrane protein 1A", "go_ids": [], "go_terms": [], "name": "Astro_1A", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR045836": {"description": "Astrovirus VPg protein", "go_ids": [], "go_terms": [], "name": "Astro_VPg", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR045837": {"description": "Bacterial toxin, RNase RnlA/LsoA, N-terminal", "go_ids": [], "go_terms": [], "name": "RnlA_toxin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045838": {"description": "DEPDC5, C-terminal", "go_ids": [], "go_terms": [], "name": "DEPDC5_CTD", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288", "R-DDI-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DDI-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR045839": {"description": "Mgp-operon protein 3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MGP3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045840": {"description": "Ariadne domain", "go_ids": [], "go_terms": [], "name": "Ariadne", "pathway_ids": ["R-BTA-9909505", "R-DME-983168", "R-DDI-9833482", "R-MMU-9909505", "R-HSA-9833482", "R-CEL-9833482", "R-HSA-983168", "R-HSA-1169408", "R-MMU-1169408", "R-CEL-983168", "R-HSA-9909505", "R-DDI-983168", "R-MMU-9833482", "R-CEL-9909505", "R-CEL-1169408", "R-DDI-9909505", "R-MMU-983168", "R-SPO-983168", "R-HSA-9833110", "R-BTA-1169408", "R-BTA-9833482", "R-DDI-1169408"], "pathways": ["R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9833482:r:PKR-mediated signaling", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9833482:r:PKR-mediated signaling", "R-CEL-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9833110:r:RSV-host interactions", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-BTA-9833482:r:PKR-mediated signaling", "R-DDI-1169408:r:ISG15 antiviral mechanism"], "type": "Domain"}, "IPR045841": {"description": "E3 ubiquitin-protein ligase UBR4, N-terminal", "go_ids": [], "go_terms": [], "name": "E3_UBR4_N", "pathway_ids": ["PWY-7511", "R-HSA-6798695", "R-DME-983168", "R-HSA-9920588", "R-DME-6798695", "R-MMU-983168", "R-MMU-6798695", "R-HSA-983168", "R-RNO-983168", "R-RNO-6798695"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR045842": {"description": "Protein furry, C-terminal", "go_ids": [], "go_terms": [], "name": "Fry_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045843": {"description": "Transcription factor IND-like", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "IND-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045845": {"description": "Serine/threonine-protein kinase BSK", "go_ids": ["GO:0004672", "GO:0009742"], "go_terms": ["GO:0004672:protein kinase activity:F", "GO:0009742:brassinosteroid mediated signaling pathway:P"], "name": "BSK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045847": {"description": "Transcription factor AIG1-like", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "AIG1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045849": {"description": "Inositol polyphosphate 5-phosphatase, plant", "go_ids": ["GO:0004445"], "go_terms": ["GO:0004445:inositol-polyphosphate 5-phosphatase activity:F"], "name": "IP5P_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045850": {"description": "tRNA (uracil(54)-C(5))-methyltransferase, metazoa type", "go_ids": [], "go_terms": [], "name": "TRM2_met", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR045851": {"description": "AMP-binding enzyme domain superfamily", "go_ids": [], "go_terms": [], "name": "AMP-b_sf", "pathway_ids": ["R-HSA-6798695", "R-DDI-71384", "R-HSA-804914", "R-HSA-1989781", "R-HSA-2151201", "R-DRE-77111", "R-HSA-389599", "R-HSA-177128", "R-MMU-75876", "R-MTU-9635470", "R-SCE-71384", "R-MMU-389599", "R-HSA-9841922", "R-RNO-9033241", "R-DRE-77289", "R-DME-71384", "R-RNO-77289", "R-RNO-434313", "R-MMU-9749641", "R-HSA-5619108", "R-HSA-77352", "R-HSA-77289", "R-MMU-434313", "R-HSA-193775", "R-HSA-177162", "R-RNO-77111", "R-BTA-77289", "R-HSA-71384", "R-MMU-2151201", "R-SPO-71384", "R-RNO-193775", "R-RNO-389599", "R-RNO-177135", "R-HSA-75105", "R-HSA-390247", "R-MMU-390247", "R-HSA-9749641", "R-MMU-6798695", "R-RNO-193368", "R-MMU-177128", "R-MMU-77289", "R-RNO-177128", "R-RNO-6798695", "R-MMU-177135", "R-RNO-75876", "R-MMU-193775", "R-BTA-77111", "R-HSA-193368", "R-MMU-77111", "R-RNO-75105", "R-HSA-177135", "R-DDI-77111", "R-HSA-77111", "R-RNO-159418", "R-CEL-77111", "R-RNO-804914", "R-MMU-193368", "R-HSA-2142753", "R-RNO-177162", "R-MMU-9033241", "R-MMU-177162", "R-MMU-75105", "R-MMU-804914", "R-HSA-434313", "R-RNO-9749641", "R-BTA-75876", "R-HSA-159418", "R-HSA-9033241", "R-HSA-75876", "R-MMU-159418", "R-RNO-390247", "R-MMU-71384"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-71384:r:Ethanol oxidation", "R-HSA-804914:r:Transport of fatty acids", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DRE-77111:r:Synthesis of Ketone Bodies", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-HSA-177128:r:Conjugation of salicylate with glycine", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-SCE-71384:r:Ethanol oxidation", "R-MMU-389599:r:Alpha-oxidation of phytanate", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-9033241:r:Peroxisomal protein import", "R-DRE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-71384:r:Ethanol oxidation", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-MMU-9749641:r:Aspirin ADME", "R-HSA-5619108:r:Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-MMU-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-HSA-177162:r:Conjugation of phenylacetate with glutamine", "R-RNO-77111:r:Synthesis of Ketone Bodies", "R-BTA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-HSA-71384:r:Ethanol oxidation", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-SPO-71384:r:Ethanol oxidation", "R-RNO-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-RNO-177135:r:Conjugation of benzoate with glycine", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-177128:r:Conjugation of salicylate with glycine", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-177128:r:Conjugation of salicylate with glycine", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-177135:r:Conjugation of benzoate with glycine", "R-RNO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-BTA-77111:r:Synthesis of Ketone Bodies", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-77111:r:Synthesis of Ketone Bodies", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-177135:r:Conjugation of benzoate with glycine", "R-DDI-77111:r:Synthesis of Ketone Bodies", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-RNO-159418:r:Recycling of bile acids and salts", "R-CEL-77111:r:Synthesis of Ketone Bodies", "R-RNO-804914:r:Transport of fatty acids", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-2142753:r:Arachidonate metabolism", "R-RNO-177162:r:Conjugation of phenylacetate with glutamine", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-177162:r:Conjugation of phenylacetate with glutamine", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-804914:r:Transport of fatty acids", "R-HSA-434313:r:Intracellular metabolism of fatty acids regulates insulin secretion", "R-RNO-9749641:r:Aspirin ADME", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-159418:r:Recycling of bile acids and salts", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-71384:r:Ethanol oxidation"], "type": "Homologous_superfamily"}, "IPR045852": {"description": "Protein UNC80, central region", "go_ids": [], "go_terms": [], "name": "UNC80_central", "pathway_ids": ["R-MMU-2672351", "R-HSA-2672351", "R-DME-2672351"], "pathways": ["R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-DME-2672351:r:Stimuli-sensing channels"], "type": "Domain"}, "IPR045853": {"description": "Peptide chain release factor class I superfamily", "go_ids": [], "go_terms": [], "name": "Pep_chain_release_fac_I_sf", "pathway_ids": ["R-MMU-5419276", "R-BTA-5419276", "R-CEL-5419276", "R-HSA-9937383", "R-HSA-5419276", "R-RNO-5419276"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination"], "type": "Homologous_superfamily"}, "IPR045854": {"description": "Nitrite and sulphite reductase 4Fe-4S domain-like superfamily", "go_ids": [], "go_terms": [], "name": "NO2/SO3_Rdtase_4Fe4S_sf", "pathway_ids": ["R-MTU-936721"], "pathways": ["R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Homologous_superfamily"}, "IPR045857": {"description": "Oligo-1,6-glucosidase, domain 2", "go_ids": [], "go_terms": [], "name": "O16G_dom_2", "pathway_ids": ["R-MTU-868688", "R-HSA-352230", "R-RNO-352230", "R-HSA-5619113", "R-HSA-5660883", "R-MMU-352230", "R-SCE-352230"], "pathways": ["R-MTU-868688:r:Trehalose biosynthesis", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-HSA-5619113:r:Defective SLC3A1 causes cystinuria (CSNU)", "R-HSA-5660883:r:Defective SLC7A9 causes cystinuria (CSNU)", "R-MMU-352230:r:Amino acid transport across the plasma membrane", "R-SCE-352230:r:Amino acid transport across the plasma membrane"], "type": "Homologous_superfamily"}, "IPR045860": {"description": "Snake toxin-like superfamily", "go_ids": [], "go_terms": [], "name": "Snake_toxin-like_sf", "pathway_ids": ["R-DME-2173789", "R-HSA-6798695", "R-MMU-9839406", "R-HSA-9839406", "R-MMU-204005", "R-MMU-163125", "R-BTA-5689880", "R-HSA-8963889", "R-DME-2173788", "R-HSA-5689880", "R-MMU-5694530", "R-HSA-9918485", "R-MMU-2173791", "R-HSA-162791", "R-BTA-6798695", "R-HSA-8963901", "R-BTA-2173789", "R-HSA-5694530", "R-RNO-162791", "R-MMU-975634", "R-MMU-5689880", "R-MMU-202733", "R-BTA-163125", "R-HSA-75205", "R-HSA-2173789", "R-HSA-202733", "R-HSA-3645790", "R-CEL-2173788", "R-MMU-162791", "R-GGA-201451", "R-BTA-1502540", "R-HSA-1502540", "R-BTA-2173788", "R-DME-2173791", "R-RNO-163125", "R-RNO-5689880", "R-RNO-2173791", "R-HSA-163125", "R-HSA-204005", "R-MMU-8963901", "R-SSC-6807878", "R-GGA-9839389", "R-MMU-6798695", "R-RNO-1502540", "R-HSA-5689603", "R-HSA-3642279", "R-CEL-2173789", "R-DME-201451", "R-MMU-2173788", "R-RNO-6798695", "R-SSC-6798695", "R-GGA-2173789", "R-DME-1502540", "R-HSA-3656535", "R-BTA-201451", "R-HSA-201451", "R-GGA-1502540", "R-RNO-2173788", "R-MMU-6807878", "R-HSA-3656532", "R-HSA-9839389", "R-BTA-9839389", "R-HSA-1181150", "R-SSC-5694530", "R-HSA-977606", "R-BTA-162791", "R-MMU-201451", "R-RNO-201451", "R-RNO-9839389", "R-RNO-75205", "R-RNO-2173789", "R-MMU-1502540", "R-GGA-2173788", "R-RNO-5694530", "R-MMU-977606", "R-MMU-2173789", "R-MMU-9839389", "R-RNO-6807878", "R-HSA-2173791", "R-BTA-2173791", "R-HSA-6807878", "R-HSA-3304356", "R-MMU-75205", "R-MMU-8963889", "R-BTA-9839406", "R-HSA-140875", "R-RNO-204005", "R-GGA-2173791", "R-MMU-140875", "R-SSC-977606", "R-GGA-9839406", "R-HSA-1433617", "R-DME-9839389", "R-BTA-75205", "R-HSA-975634", "R-HSA-2173788", "R-SSC-204005", "R-RNO-9839406", "R-DME-5689880"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-162791:r:Attachment of GPI anchor to uPAR", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-8963901:r:Chylomicron remodeling", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-162791:r:Attachment of GPI anchor to uPAR", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-3645790:r:TGFBR2 Kinase Domain Mutants in Cancer", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-GGA-201451:r:Signaling by BMP", "R-BTA-1502540:r:Signaling by Activin", "R-HSA-1502540:r:Signaling by Activin", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-8963901:r:Chylomicron remodeling", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-GGA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-1502540:r:Signaling by Activin", "R-HSA-5689603:r:UCH proteinases", "R-HSA-3642279:r:TGFBR2 MSI Frameshift Mutants in Cancer", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-201451:r:Signaling by BMP", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-GGA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-1502540:r:Signaling by Activin", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-GGA-1502540:r:Signaling by Activin", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-3656532:r:TGFBR1 KD Mutants in Cancer", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-1181150:r:Signaling by NODAL", "R-SSC-5694530:r:Cargo concentration in the ER", "R-HSA-977606:r:Regulation of Complement cascade", "R-BTA-162791:r:Attachment of GPI anchor to uPAR", "R-MMU-201451:r:Signaling by BMP", "R-RNO-201451:r:Signaling by BMP", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-1502540:r:Signaling by Activin", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-RNO-5694530:r:Cargo concentration in the ER", "R-MMU-977606:r:Regulation of Complement cascade", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-3304356:r:SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-BTA-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-SSC-977606:r:Regulation of Complement cascade", "R-GGA-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-1433617:r:Regulation of signaling by NODAL", "R-DME-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-75205:r:Dissolution of Fibrin Clot", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SSC-204005:r:COPII-mediated vesicle transport", "R-RNO-9839406:r:TGFBR3 regulates activin signaling", "R-DME-5689880:r:Ub-specific processing proteases"], "type": "Homologous_superfamily"}, "IPR045861": {"description": "CorA, cytoplasmic domain", "go_ids": [], "go_terms": [], "name": "CorA_cytoplasmic_dom", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR045862": {"description": "Nucleotidyltransferase Trf4-like", "go_ids": ["GO:1990817"], "go_terms": ["GO:1990817:poly(A) RNA polymerase activity:F"], "name": "Trf4-like", "pathway_ids": ["R-HSA-6802952", "R-HSA-9930044"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9930044:r:Nuclear RNA decay"], "type": "Family"}, "IPR045863": {"description": "CorA, transmembrane region", "go_ids": [], "go_terms": [], "name": "CorA_TM1_TM2", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR045864": {"description": "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)", "go_ids": [], "go_terms": [], "name": "aa-tRNA-synth_II/BPL/LPL", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-HSA-2408557", "R-DDI-9856649", "R-HSA-2151201", "R-MMU-9913635", "R-RNO-9856649", "R-MMU-9857492", "R-SCE-9856649", "R-DME-9856649", "R-HSA-196780", "R-SCE-9857492", "R-BTA-9857492", "R-HSA-379716", "R-HSA-3371599", "R-MMU-196780", "R-HSA-9857492", "R-SPO-9857492", "R-SPO-196780", "R-HSA-2408522", "R-HSA-6782315", "R-PFA-9857492", "R-DME-9857492", "R-XTR-9857492", "R-DRE-9857492", "R-SPO-9856649", "R-DME-9913635", "R-HSA-9856649", "R-SCE-196780", "R-CEL-9856649", "R-BTA-9913635", "R-HSA-9633012", "R-HSA-9913635"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-2408557:r:Selenocysteine synthesis", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-MMU-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-MMU-9857492:r:Protein lipoylation", "R-SCE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-196780:r:Biotin transport and metabolism", "R-SCE-9857492:r:Protein lipoylation", "R-BTA-9857492:r:Protein lipoylation", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-9857492:r:Protein lipoylation", "R-SPO-9857492:r:Protein lipoylation", "R-SPO-196780:r:Biotin transport and metabolism", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-PFA-9857492:r:Protein lipoylation", "R-DME-9857492:r:Protein lipoylation", "R-XTR-9857492:r:Protein lipoylation", "R-DRE-9857492:r:Protein lipoylation", "R-SPO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SCE-196780:r:Biotin transport and metabolism", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication"], "type": "Homologous_superfamily"}, "IPR045865": {"description": "ACT-like domain", "go_ids": [], "go_terms": [], "name": "ACT-like_dom_sf", "pathway_ids": ["R-HSA-2160456", "R-HSA-8964208", "R-MMU-209905", "R-DDI-209931", "R-DME-209905", "R-MMU-9639288", "R-HSA-209905", "R-HSA-9639288", "R-DME-8964208", "R-BTA-8964208", "R-MMU-8964208", "R-RNO-8964208", "R-RNO-209905", "R-HSA-209931", "R-XTR-9639288", "R-DDI-8964208", "R-RNO-9639288", 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{"description": "Protein of unknown function DUF6355", "go_ids": [], "go_terms": [], "name": "DUF6355", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045936": {"description": "Protein of unknown function DUF6356", "go_ids": [], "go_terms": [], "name": "DUF6356", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045937": {"description": "Protein of unknown function DUF6357", "go_ids": [], "go_terms": [], "name": "DUF6357", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045938": {"description": "Protein of unknown function DUF6358", "go_ids": [], "go_terms": [], "name": "DUF6358", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045939": {"description": "Endonuclease YhcR, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YhcR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045940": {"description": "Protein of unknown function DUF6360", "go_ids": [], "go_terms": [], "name": "DUF6360", "pathway_ids": [], "pathways": [], 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[], "go_terms": [], "name": "DUF6381", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045962": {"description": "Domain of unknown function DUF6382", "go_ids": [], "go_terms": [], "name": "DUF6382", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045963": {"description": "Domain of unknown function DUF6383", "go_ids": [], "go_terms": [], "name": "DUF6383", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045964": {"description": "Protein of unknown function DUF6384", "go_ids": [], "go_terms": [], "name": "DUF6384", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR045965": {"description": "Domain of unknown function DUF6385", "go_ids": [], "go_terms": [], "name": "DUF6385", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045967": {"description": "HAM1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HAM1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045968": {"description": "Domain of unknown function DUF5924", "go_ids": [], "go_terms": [], "name": "DUF5924", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045969": {"description": "Domain of unknown function DUF5925", "go_ids": [], "go_terms": [], "name": "DUF5925", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045970": {"description": "Protein of unknown function DUF5926", "go_ids": [], "go_terms": [], "name": "DUF5926", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045971": {"description": "Domain of unknown function DUF5927", "go_ids": [], "go_terms": [], "name": "DUF5927", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045972": {"description": "Domain of unknown function DUF5928", "go_ids": [], "go_terms": [], "name": "DUF5928", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045973": {"description": "Domain of unknown function DUF5929", "go_ids": [], "go_terms": [], "name": "DUF5929", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR045974": {"description": "Domain 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[], "type": "Family"}, "IPR046017": {"description": "Protein of unknown function DUF5974", "go_ids": [], "go_terms": [], "name": "DUF5974", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046018": {"description": "Protein of unknown function DUF5975", "go_ids": [], "go_terms": [], "name": "DUF5975", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046019": {"description": "Protein of unknown function DUF5976", "go_ids": [], "go_terms": [], "name": "DUF5976", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046020": {"description": "Protein of unknown function DUF5977", "go_ids": [], "go_terms": [], "name": "DUF5977", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046021": {"description": "Domain of unknown function DUF5978", "go_ids": [], "go_terms": [], "name": "DUF5978", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046022": {"description": "Domain of unknown function DUF5979", "go_ids": [], "go_terms": [], "name": "DUF5979", 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[], "name": "DUF5986", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046029": {"description": "Protein of unknown function DUF5987", "go_ids": [], "go_terms": [], "name": "DUF5987", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046030": {"description": "Protein of unknown function DUF5988", "go_ids": [], "go_terms": [], "name": "DUF5988", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046031": {"description": "Protein of unknown function DUF5989", "go_ids": [], "go_terms": [], "name": "DUF5989", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046032": {"description": "Protein of unknown function DUF5990", "go_ids": [], "go_terms": [], "name": "DUF5990", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046033": {"description": "Protein of unknown function DUF5991", "go_ids": [], "go_terms": [], "name": "DUF5991", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046034": {"description": "Protein of unknown function DUF5992", 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unknown function DUF5998", "go_ids": [], "go_terms": [], "name": "DUF5998", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046041": {"description": "Protein of unknown function DUF5999", "go_ids": [], "go_terms": [], "name": "DUF5999", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046042": {"description": "Protein of unknown function DUF6000", "go_ids": [], "go_terms": [], "name": "DUF6000", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046043": {"description": "Protein of unknown function DUF6001", "go_ids": [], "go_terms": [], "name": "DUF6001", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046044": {"description": "Protein of unknown function DUF6002", "go_ids": [], "go_terms": [], "name": "DUF6002", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046045": {"description": "Protein of unknown function DUF6003", "go_ids": [], "go_terms": [], "name": "DUF6003", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046046": {"description": "Protein of unknown function DUF6004", "go_ids": [], "go_terms": [], "name": "DUF6004", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046047": {"description": "DUF6005, N-terminal", "go_ids": [], "go_terms": [], "name": "DUF6005_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046048": {"description": "Protein of unknown function DUF6006", "go_ids": [], "go_terms": [], "name": "DUF6006", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046049": {"description": "Protein of unknown function DUF6007", "go_ids": [], "go_terms": [], "name": "DUF6007", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046050": {"description": "Protein of unknown function DUF6008", "go_ids": [], "go_terms": [], "name": "DUF6008", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046051": {"description": "Protein of unknown function DUF6009", "go_ids": [], "go_terms": [], "name": "DUF6009", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046052": {"description": "Protein of unknown function DUF6010", "go_ids": [], "go_terms": [], "name": "DUF6010", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046053": {"description": "Protein of unknown function DUF6011", "go_ids": [], "go_terms": [], "name": "DUF6011", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046054": {"description": "Protein of unknown function DUF6012", "go_ids": [], "go_terms": [], "name": "DUF6012", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046055": {"description": "Protein of unknown function DUF6013", "go_ids": [], "go_terms": [], "name": "DUF6013", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046056": {"description": "Protein of unknown function DUF6014", "go_ids": [], "go_terms": [], "name": "DUF6014", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046057": {"description": "Protein of unknown function DUF6015", "go_ids": [], "go_terms": [], "name": "DUF6015", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046058": {"description": "Cupin fold metalloprotein WbuC, cupin domain", "go_ids": [], "go_terms": [], "name": "WbuC_cupin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046059": {"description": "Domain of unknown function DUF6017", "go_ids": [], "go_terms": [], "name": "DUF6017", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046060": {"description": "Protein of unknown function DUF6018", "go_ids": [], "go_terms": [], "name": "DUF6018", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046061": {"description": "Protein of unknown function DUF6019", "go_ids": [], "go_terms": [], "name": "DUF6019", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046062": {"description": "Protein of unknown function DUF6020", "go_ids": [], "go_terms": [], "name": "DUF6020", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046063": {"description": "Protein of unknown function DUF6021", "go_ids": [], "go_terms": [], "name": "DUF6021", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046064": {"description": "Protein of unknown function DUF6022", "go_ids": [], "go_terms": [], "name": "DUF6022", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046065": {"description": "Protein of unknown function DUF6023", "go_ids": [], "go_terms": [], "name": "DUF6023", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046066": {"description": "Protein of unknown function DUF6024", "go_ids": [], "go_terms": [], "name": "DUF6024", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046067": {"description": "Protein of unknown function DUF6025", "go_ids": [], "go_terms": [], "name": "DUF6025", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046068": {"description": "Protein of unknown function DUF6026", "go_ids": [], "go_terms": [], "name": "DUF6026", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046069": {"description": "Protein of unknown function DUF6027", "go_ids": [], "go_terms": [], "name": "DUF6027", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046070": {"description": "Protein of unknown function DUF6029", "go_ids": [], "go_terms": [], "name": "DUF6029", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046071": {"description": "Protein of unknown function DUF6030", "go_ids": [], "go_terms": [], "name": "DUF6030", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046072": {"description": "Protein of unknown function DUF6031", "go_ids": [], "go_terms": [], "name": "DUF6031", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046073": {"description": "Protein of unknown function DUF6032", "go_ids": [], "go_terms": [], "name": "DUF6032", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046074": {"description": "Protein of unknown function DUF6092", "go_ids": [], "go_terms": [], "name": "DUF6092", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046075": {"description": "Protein of unknown function DUF6093", "go_ids": [], "go_terms": [], "name": "DUF6093", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046076": {"description": "Domain of unknown function DUF6094", "go_ids": [], "go_terms": [], "name": "DUF6094", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046077": {"description": "Protein of unknown function DUF6095", "go_ids": [], "go_terms": [], "name": "DUF6095", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046078": {"description": "Protein of unknown function DUF6096", "go_ids": [], "go_terms": [], "name": "DUF6096", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046079": {"description": "Protein of unknown function DUF6097", "go_ids": [], "go_terms": [], "name": "DUF6097", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046080": {"description": "Protein of unknown function DUF6098", "go_ids": [], "go_terms": [], "name": "DUF6098", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046081": {"description": "Protein of unknown function DUF6099", "go_ids": [], "go_terms": [], "name": "DUF6099", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046082": {"description": "Protein of unknown function DUF6100", "go_ids": [], "go_terms": [], "name": "DUF6100", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046083": {"description": "Protein of unknown function DUF6101", "go_ids": [], "go_terms": [], "name": "DUF6101", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046084": {"description": "Conjugal transfer protein TrbL", "go_ids": [], "go_terms": [], "name": "TrbL_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046085": {"description": "Protein of unknown function DUF6103", "go_ids": [], "go_terms": [], "name": "DUF6103", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046086": {"description": "Protein of unknown function DUF6104", "go_ids": [], "go_terms": [], "name": "DUF6104", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046087": {"description": "Protein of unknown function DUF6105", "go_ids": [], "go_terms": [], "name": "DUF6105", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046088": {"description": "Protein of unknown function DUF6106", "go_ids": [], "go_terms": [], "name": "DUF6106", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046089": {"description": "Protein of unknown function DUF6107", "go_ids": [], "go_terms": [], "name": "DUF6107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046090": {"description": "Protein of unknown function DUF6108", "go_ids": [], "go_terms": [], "name": "DUF6108", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046091": {"description": "Protein of unknown function DUF6109", "go_ids": [], "go_terms": [], "name": "DUF6109", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046092": {"description": "Protein of unknown function DUF6110", "go_ids": [], "go_terms": [], "name": "DUF6110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046093": {"description": "Protein of unknown function DUF6111", "go_ids": [], "go_terms": [], "name": "DUF6111", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046094": {"description": "Protein of unknown function DUF6112", "go_ids": [], "go_terms": [], "name": "DUF6112", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046095": {"description": "Protein of unknown function DUF6113", "go_ids": [], "go_terms": [], "name": "DUF6113", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046096": {"description": "Protein of unknown function DUF6114", "go_ids": [], "go_terms": [], "name": "DUF6114", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046097": {"description": "Protein of unknown function DUF6033", "go_ids": [], "go_terms": [], "name": "DUF6033", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046098": {"description": "Protein of unknown function DUF6034", "go_ids": [], "go_terms": [], "name": "DUF6034", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046099": {"description": "Domain of unknown function DUF6035", "go_ids": [], "go_terms": [], "name": "DUF6035", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046100": {"description": "Protein of unknown function DUF6037", "go_ids": [], "go_terms": [], "name": "DUF6037", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046101": {"description": "Protein of unknown function DUF6038", "go_ids": [], "go_terms": [], "name": "DUF6038", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046102": {"description": "Protein of unknown function DUF6039", "go_ids": [], "go_terms": [], "name": "DUF6039", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046103": {"description": "Protein of unknown function DUF6040", "go_ids": [], "go_terms": [], "name": "DUF6040", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046104": {"description": "Protein of unknown function DUF6041", "go_ids": [], "go_terms": [], "name": "DUF6041", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046105": {"description": "Protein of unknown function DUF6042", "go_ids": [], "go_terms": [], "name": "DUF6042", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046106": {"description": "Protein of unknown function DUF6043", "go_ids": [], "go_terms": [], "name": "DUF6043", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046107": {"description": "Protein of unknown function DUF6044", "go_ids": [], "go_terms": [], "name": "DUF6044", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046108": {"description": "Conjugal transfer protein TrbL-like", "go_ids": [], "go_terms": [], "name": "TrbL_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046109": {"description": "Domain of unknown function DUF6046", "go_ids": [], "go_terms": [], "name": "DUF6046", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046110": {"description": "Protein of unknown function DUF6047", "go_ids": [], "go_terms": [], "name": "DUF6047", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046111": {"description": "Protein of unknown function DUF6048", "go_ids": [], "go_terms": [], "name": "DUF6048", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046112": {"description": "Protein of unknown function DUF6049", "go_ids": [], "go_terms": [], "name": "DUF6049", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046113": {"description": "Protein of unknown function DUF6050", "go_ids": [], "go_terms": [], "name": "DUF6050", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046114": {"description": "Protein of unknown function DUF6051", "go_ids": [], "go_terms": [], "name": "DUF6051", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046115": {"description": "Protein of unknown function DUF6052", "go_ids": [], "go_terms": [], "name": "DUF6052", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046116": {"description": "Protein of unknown function DUF6053", "go_ids": [], "go_terms": [], "name": "DUF6053", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046117": {"description": "Protein of unknown function DUF6054", "go_ids": [], "go_terms": [], "name": "DUF6054", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046118": {"description": "Domain of unknown function DUF6115", "go_ids": [], "go_terms": [], "name": "DUF6115", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046119": {"description": "Protein of unknown function DUF6116", "go_ids": [], "go_terms": [], "name": "DUF6116", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046120": {"description": "Protein of unknown function DUF6117", "go_ids": [], "go_terms": [], "name": "DUF6117", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046121": {"description": "Protein of unknown function DUF6118", "go_ids": [], "go_terms": [], "name": "DUF6118", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046123": {"description": "Protein of unknown function DUF6120", "go_ids": [], "go_terms": [], "name": "DUF6120", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046124": {"description": "Protein of unknown function DUF6121", "go_ids": [], "go_terms": [], "name": "DUF6121", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046125": {"description": "Protein of unknown function DUF6122", "go_ids": [], "go_terms": [], "name": "DUF6122", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046126": {"description": "Protein of unknown function DUF6123", "go_ids": [], "go_terms": [], "name": "DUF6123", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046128": {"description": "Protein of unknown function DUF6125", "go_ids": [], "go_terms": [], "name": "DUF6125", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046129": {"description": "Protein of unknown function DUF6126", "go_ids": [], "go_terms": [], "name": "DUF6126", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046130": {"description": "Protein of unknown function DUF6127", "go_ids": [], "go_terms": [], "name": "DUF6127", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046131": {"description": "Domain of unknown function DUF6128", "go_ids": [], "go_terms": [], "name": "DUF6128", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046132": {"description": "Domain of unknown function DUF6129", "go_ids": [], "go_terms": [], "name": "DUF6129", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046133": {"description": "Protein of unknown function DUF6130", "go_ids": [], "go_terms": [], "name": "DUF6130", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046134": {"description": "Protein of unknown function DUF6131", "go_ids": [], "go_terms": [], "name": "DUF6131", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046135": {"description": "Protein of unknown function DUF6137", "go_ids": [], "go_terms": [], "name": "DUF6137", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046136": {"description": "Protein of unknown function DUF6138", "go_ids": [], "go_terms": [], "name": "DUF6138", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046137": {"description": "Protein of unknown function DUF6139", "go_ids": [], "go_terms": [], "name": "DUF6139", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046138": {"description": "Protein of unknown function DUF6140", "go_ids": [], "go_terms": [], "name": "DUF6140", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046139": {"description": "Protein of unknown function DUF6141", "go_ids": [], "go_terms": [], "name": "DUF6141", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046140": {"description": "Protein of unknown function DUF6142", "go_ids": [], "go_terms": [], "name": "DUF6142", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046141": {"description": "Protein of unknown function DUF6143", "go_ids": [], "go_terms": [], "name": "DUF6143", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046142": {"description": "Protein of unknown function DUF6144", "go_ids": [], "go_terms": [], "name": "DUF6144", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046143": {"description": "Protein of unknown function DUF6145", "go_ids": [], "go_terms": [], "name": "DUF6145", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046144": {"description": "Protein of unknown function DUF6146", "go_ids": [], "go_terms": [], "name": "DUF6146", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046145": {"description": "Protein of unknown function DUF6147", "go_ids": [], "go_terms": [], "name": "DUF6147", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046146": {"description": "Protein of unknown function DUF6148", "go_ids": [], "go_terms": [], "name": "DUF6148", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046147": {"description": "Protein of unknown function DUF6149", "go_ids": [], "go_terms": [], "name": "DUF6149", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046148": {"description": "7(1) septoil knot domain", "go_ids": [], "go_terms": [], "name": "Septknot", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046149": {"description": "Protein of unknown function DUF6151", "go_ids": [], "go_terms": [], "name": "DUF6151", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046150": {"description": "Protein of unknown function DUF6152", "go_ids": [], "go_terms": [], "name": "DUF6152", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046151": {"description": "Protein of unknown function DUF6153", "go_ids": [], "go_terms": [], "name": "DUF6153", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046152": {"description": "Protein of unknown function DUF6154", "go_ids": [], "go_terms": [], "name": "DUF6154", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046153": {"description": "Protein of unknown function DUF6155", "go_ids": [], "go_terms": [], "name": "DUF6155", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046154": {"description": "Protein of unknown function DUF6156", "go_ids": [], "go_terms": [], "name": "DUF6156", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046155": {"description": "Protein of unknown function DUF6157", "go_ids": [], "go_terms": [], "name": "DUF6157", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046156": {"description": "Protein of unknown function DUF6158", "go_ids": [], "go_terms": [], "name": "DUF6158", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046157": {"description": "Protein of unknown function DUF6159", "go_ids": [], "go_terms": [], "name": "DUF6159", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046158": {"description": "Domain of unknown function DUF6160", "go_ids": [], "go_terms": [], "name": "DUF6160", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046159": {"description": "Domain of unknown function DUF6161", "go_ids": [], "go_terms": [], "name": "DUF6161", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046160": {"description": "Protein of unknown function DUF6162", "go_ids": [], "go_terms": [], "name": "DUF6162", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046161": {"description": "Protein of unknown function DUF6163", "go_ids": [], "go_terms": [], "name": "DUF6163", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046162": {"description": "Protein of unknown function DUF6164", "go_ids": [], "go_terms": [], "name": "DUF6164", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046163": {"description": "Protein of unknown function DUF6165", "go_ids": [], "go_terms": [], "name": "DUF6165", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046164": {"description": "Protein of unknown function DUF6166", "go_ids": [], "go_terms": [], "name": "DUF6166", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046165": {"description": "Protein of unknown function DUF6167", "go_ids": [], "go_terms": [], "name": "DUF6167", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046166": {"description": "Protein of unknown function DUF6168", "go_ids": [], "go_terms": [], "name": "DUF6168", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046167": {"description": "Protein of unknown function DUF6169", "go_ids": [], "go_terms": [], "name": "DUF6169", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046168": {"description": "Protein of unknown function DUF6170", "go_ids": [], "go_terms": [], "name": "DUF6170", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046169": {"description": "Protein of unknown function DUF6171", "go_ids": [], "go_terms": [], "name": "DUF6171", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046170": {"description": "Protein of unknown function DUF6172", "go_ids": [], "go_terms": [], "name": "DUF6172", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046171": {"description": "Protein of unknown function DUF6173", "go_ids": [], "go_terms": [], "name": "DUF6173", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046172": {"description": "Protein of unknown function DUF6174", "go_ids": [], "go_terms": [], "name": "DUF6174", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046173": {"description": "Domain of unknown function DUF6175", "go_ids": [], "go_terms": [], "name": "DUF6175", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046174": {"description": "Protein of unknown function DUF6176", "go_ids": [], "go_terms": [], "name": "DUF6176", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046175": {"description": "Protein of unknown function DUF6177", "go_ids": [], "go_terms": [], "name": "DUF6177", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046176": {"description": "Protein of unknown function DUF6185", "go_ids": [], "go_terms": [], "name": "DUF6185", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046177": {"description": "Domain of unknown function DUF6186", "go_ids": [], "go_terms": [], "name": "DUF6186", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046178": {"description": "Protein of unknown function DUF6187", "go_ids": [], "go_terms": [], "name": "DUF6187", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046179": {"description": "Protein of unknown function DUF6188", "go_ids": [], "go_terms": [], "name": "DUF6188", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046180": {"description": "Protein of unknown function DUF6208", "go_ids": [], "go_terms": [], "name": "DUF6208", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046181": {"description": "Protein of unknown function DUF6209", "go_ids": [], "go_terms": [], "name": "DUF6209", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046182": {"description": "Protein of unknown function DUF6210", "go_ids": [], "go_terms": [], "name": "DUF6210", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046183": {"description": "Protein of unknown function DUF6211", "go_ids": [], "go_terms": [], "name": "DUF6211", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046184": {"description": "Protein of unknown function DUF6212", "go_ids": [], "go_terms": [], "name": "DUF6212", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046185": {"description": "Protein of unknown function DUF6213", "go_ids": [], "go_terms": [], "name": "DUF6213", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046186": {"description": "Protein of unknown function DUF6214", "go_ids": [], "go_terms": [], "name": "DUF6214", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046187": {"description": "Protein of unknown function DUF6215", "go_ids": [], "go_terms": [], "name": "DUF6215", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046188": {"description": "Protein of unknown function DUF6216", "go_ids": [], "go_terms": [], "name": "DUF6216", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046189": {"description": "Protein of unknown function DUF6217", "go_ids": [], "go_terms": [], "name": "DUF6217", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046190": {"description": "Protein of unknown function DUF6218", "go_ids": [], "go_terms": [], "name": "DUF6218", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046191": {"description": "Protein of unknown function DUF6219", "go_ids": [], "go_terms": [], "name": "DUF6219", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046192": {"description": "Protein of unknown function DUF6220", "go_ids": [], "go_terms": [], "name": "DUF6220", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046193": {"description": "Protein of unknown function DUF6221", "go_ids": [], "go_terms": [], "name": "DUF6221", "pathway_ids": [], "pathways": [], "type": "Family"}, 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"pathways": [], "type": "Family"}, "IPR046200": {"description": "Protein of unknown function DUF6233", "go_ids": [], "go_terms": [], "name": "DUF6233", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046201": {"description": "Domain of unknown function DUF6234", "go_ids": [], "go_terms": [], "name": "DUF6234", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046202": {"description": "Protein of unknown function DUF6235", "go_ids": [], "go_terms": [], "name": "DUF6235", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046203": {"description": "Protein of unknown function DUF6236", "go_ids": [], "go_terms": [], "name": "DUF6236", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046204": {"description": "Protein of unknown function DUF6237", "go_ids": [], "go_terms": [], "name": "DUF6237", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046205": {"description": "Protein of unknown function DUF6238", "go_ids": [], "go_terms": [], "name": "DUF6238", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046206": {"description": "Protein of unknown function DUF6239", "go_ids": [], "go_terms": [], "name": "DUF6239", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046207": {"description": "Domain of unknown function DUF6240", "go_ids": [], "go_terms": [], "name": "DUF6240", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046208": {"description": "Protein of unknown function DUF6241", "go_ids": [], "go_terms": [], "name": "DUF6241", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046209": {"description": "Outer membrane protein assembly factor BamI, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BamI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046210": {"description": "Protein of unknown function DUF6243", "go_ids": [], "go_terms": [], "name": "DUF6243", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046211": {"description": "Protein of unknown function DUF6244", "go_ids": [], "go_terms": [], "name": "DUF6244", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046212": {"description": "Protein of unknown function DUF6245", "go_ids": [], "go_terms": [], "name": "DUF6245", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046213": {"description": "Protein of unknown function DUF6246", "go_ids": [], "go_terms": [], "name": "DUF6246", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046214": {"description": "Protein of unknown function DUF6247", "go_ids": [], "go_terms": [], "name": "DUF6247", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046215": {"description": "Protein of unknown function DUF6248", "go_ids": [], "go_terms": [], "name": "DUF6248", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046216": {"description": "Domain of unknown function DUF6249", "go_ids": [], "go_terms": [], "name": "DUF6249", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046217": {"description": "Domain of unknown function DUF6250", "go_ids": [], "go_terms": [], "name": "DUF6250", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046218": {"description": "Protein of unknown function DUF6251", "go_ids": [], "go_terms": [], "name": "DUF6251", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046219": {"description": "Domain of unknown function DUF6252", "go_ids": [], "go_terms": [], "name": "DUF6252", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046220": {"description": "Protein of unknown function DUF6253", "go_ids": [], "go_terms": [], "name": "DUF6253", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046221": {"description": "Protein of unknown function DUF6254", "go_ids": [], "go_terms": [], "name": "DUF6254", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046222": {"description": "Protein of unknown function DUF6255", "go_ids": [], "go_terms": [], "name": "DUF6255", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046223": {"description": "Protein of unknown function DUF6256", "go_ids": [], "go_terms": [], "name": "DUF6256", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046224": {"description": "Protein of unknown function DUF6257", "go_ids": [], "go_terms": [], "name": "DUF6257", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046225": {"description": "Protein of unknown function DUF6258", "go_ids": [], "go_terms": [], "name": "DUF6258", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046226": {"description": "Domain of unknown function DUF6259", "go_ids": [], "go_terms": [], "name": "DUF6259", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046227": {"description": "Protein of unknown function DUF6260", "go_ids": [], "go_terms": [], "name": "DUF6260", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046228": {"description": "Protein of unknown function DUF6261", "go_ids": [], "go_terms": [], "name": "DUF6261", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046229": {"description": "Transposase for transposon Tn554-like", "go_ids": [], "go_terms": [], "name": "TnpC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046230": {"description": "Protein of unknown function DUF6263", "go_ids": [], "go_terms": [], "name": "DUF6263", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046231": {"description": "Protein of unknown function DUF6264", "go_ids": [], "go_terms": [], "name": "DUF6264", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046232": {"description": "Domain of unknown function DUF6265", "go_ids": [], "go_terms": [], "name": "DUF6265", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046233": {"description": "Protein of unknown function DUF6266", "go_ids": [], "go_terms": [], "name": "DUF6266", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046234": {"description": "Protein of unknown function DUF6267", "go_ids": [], "go_terms": [], "name": "DUF6267", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046235": {"description": "Domain of unknown function DUF6268", "go_ids": [], "go_terms": [], "name": "DUF6268", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046236": {"description": "Protein of unknown function DUF6269", "go_ids": [], "go_terms": [], "name": "DUF6269", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046237": {"description": "Protein of unknown function DUF6270", "go_ids": [], "go_terms": [], "name": "DUF6270", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046238": {"description": "Protein of unknown function DUF6271", "go_ids": [], "go_terms": [], "name": "DUF6271", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046239": {"description": "Protein of unknown function DUF6272", "go_ids": [], "go_terms": [], "name": "DUF6272", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046240": {"description": "Domain of unknown function DUF6273", "go_ids": [], "go_terms": [], "name": "DUF6273", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046241": {"description": "Protein of unknown function DUF6274", "go_ids": [], "go_terms": [], "name": "DUF6274", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046242": {"description": "Protein of unknown function DUF6275", "go_ids": [], "go_terms": [], "name": "DUF6275", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046243": {"description": "Protein of unknown function DUF6276", "go_ids": [], "go_terms": [], "name": "DUF6276", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046244": {"description": "Protein of unknown function DUF6277", "go_ids": [], "go_terms": [], "name": "DUF6277", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046245": {"description": "Protein of unknown function DUF6278", "go_ids": [], "go_terms": [], "name": "DUF6278", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046247": {"description": "Protein of unknown function DUF6280", "go_ids": [], "go_terms": [], "name": "DUF6280", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046248": {"description": "Protein of unknown function DUF6281", "go_ids": [], "go_terms": [], "name": "DUF6281", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046249": {"description": "Protein of unknown function DUF6282", "go_ids": [], "go_terms": [], "name": "DUF6282", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046250": {"description": "Protein of unknown function DUF6283", "go_ids": [], "go_terms": [], "name": "DUF6283", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046251": {"description": "Protein of unknown function DUF6284", "go_ids": [], "go_terms": [], "name": "DUF6284", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046252": {"description": "Domain of unknown function DUF6285", "go_ids": [], "go_terms": [], "name": "DUF6285", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046253": {"description": "Domain of unknown function DUF6286", "go_ids": [], "go_terms": [], "name": "DUF6286", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046254": {"description": "Domain of unknown function DUF6287", "go_ids": [], "go_terms": [], "name": "DUF6287", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046255": {"description": "Protein of unknown function DUF6288", "go_ids": [], "go_terms": [], "name": "DUF6288", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046256": {"description": "Protein of unknown function DUF6289", "go_ids": [], "go_terms": [], "name": "DUF6289", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046257": {"description": "Protein of unknown function DUF6290", "go_ids": [], "go_terms": [], "name": "DUF6290", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046258": {"description": "Domain of unknown function DUF6291", "go_ids": [], "go_terms": [], "name": "DUF6291", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046259": {"description": "Domain of unknown function DUF6292", "go_ids": [], "go_terms": [], "name": "DUF6292", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046260": {"description": "HFX_2341-like, N-terminal", "go_ids": [], "go_terms": [], "name": "HFX_2341-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046261": {"description": "Domain of unknown function DUF6294", "go_ids": [], "go_terms": [], "name": "DUF6294", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046262": {"description": "Protein of unknown function DUF6295", "go_ids": [], "go_terms": [], "name": "DUF6295", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046263": {"description": "Protein of unknown function DUF6296", "go_ids": [], "go_terms": [], "name": "DUF6296", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046264": {"description": "Protein of unknown function DUF6297", "go_ids": [], "go_terms": [], "name": "DUF6297", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046265": {"description": "Domain of unknown function DUF6298", "go_ids": [], "go_terms": [], "name": "DUF6298", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046266": {"description": "Domain of unknown function DUF6299", "go_ids": [], "go_terms": [], "name": "DUF6299", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046267": {"description": "Protein of unknown function DUF6300", "go_ids": [], "go_terms": [], "name": "DUF6300", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046268": {"description": "Protein of unknown function DUF6301", "go_ids": [], "go_terms": [], "name": "DUF6301", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046269": {"description": "Protein of unknown function DUF6302", "go_ids": [], "go_terms": [], "name": "DUF6302", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046270": {"description": "Protein of unknown function DUF6303", "go_ids": [], "go_terms": [], "name": "DUF6303", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046271": {"description": "Protein of unknown function DUF6304", "go_ids": [], "go_terms": [], "name": "DUF6304", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046272": {"description": "Domain of unknown function DUF6305", "go_ids": [], "go_terms": [], "name": "DUF6305", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046273": {"description": "Domain of unknown function DUF6306", "go_ids": [], "go_terms": [], "name": "DUF6306", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046274": {"description": "Protein of unknown function DUF6307", "go_ids": [], "go_terms": [], "name": "DUF6307", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046275": {"description": "Protein of unknown function DUF6308", "go_ids": [], "go_terms": [], "name": "DUF6308", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046276": {"description": "Protein of unknown function DUF6309", "go_ids": [], "go_terms": [], "name": "DUF6309", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046277": {"description": "Domain of unknown function DUF6310", "go_ids": [], "go_terms": [], "name": "DUF6310", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046278": {"description": "Domain of unknown function DUF6311", "go_ids": [], "go_terms": [], "name": "DUF6311", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046279": {"description": "Protein of unknown function DUF6312", "go_ids": [], "go_terms": [], "name": "DUF6312", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046280": {"description": "Protein of unknown function DUF6313", "go_ids": [], "go_terms": [], "name": "DUF6313", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046281": {"description": "Domain of unknown function DUF6318", "go_ids": [], "go_terms": [], "name": "DUF6318", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046282": {"description": "Protein of unknown function DUF6319", "go_ids": [], "go_terms": [], "name": "DUF6319", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046283": {"description": "Protein of unknown function DUF6320", "go_ids": [], "go_terms": [], "name": "DUF6320", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046284": {"description": "Domain of unknown function DUF6321", "go_ids": [], "go_terms": [], "name": "DUF6321", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046285": {"description": "Protein of unknown function DUF6322", "go_ids": [], "go_terms": [], "name": "DUF6322", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046286": {"description": "Protein of unknown function DUF6323", "go_ids": [], "go_terms": [], "name": "DUF6323", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046287": {"description": "Protein of unknown function DUF6324", "go_ids": [], "go_terms": [], "name": "DUF6324", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046288": {"description": "Protein of unknown function DUF6325", "go_ids": [], "go_terms": [], "name": "DUF6325", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046289": {"description": "Protein of unknown function DUF6326", "go_ids": [], "go_terms": [], "name": "DUF6326", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046290": {"description": "Protein of unknown function DUF6327", "go_ids": [], "go_terms": [], "name": "DUF6327", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046291": {"description": "Protein of unknown function DUF6328", "go_ids": [], "go_terms": [], "name": "DUF6328", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046292": {"description": "Domain of unknown function DUF6329", "go_ids": [], "go_terms": [], "name": "DUF6329", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046293": {"description": "Protein of unknown function DUF6330", "go_ids": [], "go_terms": [], "name": "DUF6330", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046294": {"description": "Protein of unknown function DUF6331", "go_ids": [], "go_terms": [], "name": "DUF6331", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046295": {"description": "Protein of unknown function DUF6332", "go_ids": [], "go_terms": [], "name": "DUF6332", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046296": {"description": "Protein of unknown function DUF6333", "go_ids": [], "go_terms": [], "name": "DUF6333", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046297": {"description": "Protein of unknown function DUF6334", "go_ids": [], "go_terms": [], "name": "DUF6334", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046298": {"description": "Protein of unknown function DUF6335", "go_ids": [], "go_terms": [], "name": "DUF6335", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046299": {"description": "Protein of unknown function DUF6336", "go_ids": [], "go_terms": [], "name": "DUF6336", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046300": {"description": "Domain of unknown function DUF6415", "go_ids": [], "go_terms": [], "name": "DUF6415", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046301": {"description": "Protein of unknown function DUF6416", "go_ids": [], "go_terms": [], "name": "DUF6416", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046302": {"description": "Protein of unknown function DUF6417", "go_ids": [], "go_terms": [], "name": "DUF6417", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046303": {"description": "Domain of unknown function DUF6418", "go_ids": [], "go_terms": [], "name": "DUF6418", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046304": {"description": "Protein of unknown function DUF6419", "go_ids": [], "go_terms": [], "name": "DUF6419", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046305": {"description": "Protein of unknown function DUF6420", "go_ids": [], "go_terms": [], "name": "DUF6420", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046306": {"description": "Protein of unknown function DUF6421", "go_ids": [], "go_terms": [], "name": "DUF6421", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046307": {"description": "Protein of unknown function DUF6422", "go_ids": [], "go_terms": [], "name": "DUF6422", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046308": {"description": "Protein of unknown function DUF6423", "go_ids": [], "go_terms": [], "name": "DUF6423", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046309": {"description": "Protein of unknown function DUF6424", "go_ids": [], "go_terms": [], "name": "DUF6424", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046310": {"description": "Protein of unknown function DUF6425", "go_ids": [], "go_terms": [], "name": "DUF6425", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046311": {"description": "Protein of unknown function DUF6426", "go_ids": [], "go_terms": [], "name": "DUF6426", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046312": {"description": "Protein of unknown function DUF6454", "go_ids": [], "go_terms": [], "name": "DUF6454", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046313": {"description": "Protein of unknown function DUF6465", "go_ids": [], "go_terms": [], "name": "DUF6465", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046314": {"description": "Protein of unknown function DUF6466", "go_ids": [], "go_terms": [], "name": "DUF6466", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046318": {"description": "Protein of unknown function DUF5344", "go_ids": [], "go_terms": [], "name": "DUF5344", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046320": {"description": "Domain of unknown function DUF4922", "go_ids": [], "go_terms": [], "name": "DUF4922", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046322": {"description": "DUF4931, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF4931", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046327": {"description": "Homeobox protein Hox-A1/B1/D1", "go_ids": ["GO:0006357", "GO:0043565", "GO:0003700"], "go_terms": ["GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0043565:sequence-specific DNA binding:F", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "HXA1/B1/D1", "pathway_ids": ["R-HSA-5617472"], "pathways": ["R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "type": "Family"}, "IPR046328": {"description": "ETS family", "go_ids": ["GO:0003700", "GO:0006357"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P"], "name": "ETS_fam", "pathway_ids": ["R-DME-8939245", "R-HSA-198753", "R-HSA-8939247", "R-HSA-2151201", "R-BTA-2559585", "R-HSA-2559585", "R-DME-8939247", "R-CEL-2559585", "R-MMU-8939247", "R-HSA-9609690", "R-HSA-9634638", "R-HSA-9673768", "R-DME-2559585", "R-MMU-2151201", "R-RNO-1912408", "R-BTA-8939247", "R-HSA-1912408", "R-DME-5687128", "R-HSA-9703465", "R-MMU-8939245", "R-DME-2151201", "R-HSA-8939245", "R-GGA-2559585", "R-HSA-5687128", "R-MMU-1912408", "R-HSA-9927418", "R-HSA-9616222", "R-HSA-9031628", "R-MMU-5687128", "R-HSA-8939236", "R-MMU-2559585", "R-HSA-9927426", "R-RNO-2559585"], "pathways": ["R-DME-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-198753:r:ERK/MAPK targets", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-DME-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-CEL-2559585:r:Oncogene Induced Senescence", "R-MMU-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-DME-2559585:r:Oncogene Induced Senescence", "R-MMU-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-RNO-1912408:r:Pre-NOTCH Transcription and Translation", "R-BTA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-DME-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-MMU-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-GGA-2559585:r:Oncogene Induced Senescence", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9031628:r:NGF-stimulated transcription", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-RNO-2559585:r:Oncogene Induced Senescence"], "type": "Family"}, "IPR046331": {"description": "GPALPP motifs-containing protein 1-like", "go_ids": [], "go_terms": [], "name": "GPAM1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046333": {"description": "Homeobox protein Hox-A10/abdominal-B-like", "go_ids": [], "go_terms": [], "name": "HXA10/ABDB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046335": {"description": "Transcriptional regulator LacI/GalR-like, sensor domain", "go_ids": [], "go_terms": [], "name": "LacI/GalR-like_sensor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046336": {"description": "Lon protease, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Lon_prtase_N_sf", "pathway_ids": ["R-BTA-9033241", "R-RNO-9033241", "R-MMU-9837999", "R-CEL-9837999", "R-HSA-390471", "R-SPO-9837999", "R-SCE-9837999", "R-MMU-983168", "R-SPO-983168", "R-HSA-9841251", "R-DME-9837999", "R-HSA-9837999", "R-HSA-9679191", "R-HSA-983168", "R-RNO-9837999", "R-MMU-9033241", "R-HSA-9033241"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Homologous_superfamily"}, "IPR046338": {"description": "GAIN domain superfamily", "go_ids": [], "go_terms": [], "name": "GAIN_dom_sf", "pathway_ids": ["R-HSA-6798695", "R-DME-350379", "R-HSA-373080", "R-DRE-9619665", "R-CEL-373080", "R-CEL-9619665", "R-DME-6798695", "R-CEL-6798695", "R-DME-9619665", "R-DME-373080", "R-HSA-9619665", "R-DME-350368", "R-DME-350480", "R-MMU-373080", "R-RNO-5683826", "R-DME-350376", "R-HSA-5683826", "R-DME-350411", "R-MMU-6798695", "R-RNO-373080", "R-MMU-9619665", "R-DME-450728", "R-MMU-5683826"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-DRE-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-CEL-373080:r:Class B/2 (Secretin family receptors)", "R-CEL-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-RNO-5683826:r:Surfactant metabolism", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-HSA-5683826:r:Surfactant metabolism", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-450728:r:Inhibition of actin polymerization", "R-MMU-5683826:r:Surfactant metabolism"], "type": "Homologous_superfamily"}, "IPR046341": {"description": "SET domain superfamily", "go_ids": [], "go_terms": [], "name": "SET_dom_sf", "pathway_ids": ["R-SCE-9772755", "R-MMU-8953750", "R-HSA-2559580", "R-XTR-6804760", "R-HSA-8936459", "R-MMU-201722", "R-XTR-9764725", "R-HSA-5693565", "R-BTA-2299718", "R-SPO-3214841", "R-BTA-3214841", "R-HSA-9841922", "R-MMU-69473", "R-HSA-5693607", "R-HSA-427359", "R-HSA-9844594", "R-HSA-6804754", "R-DME-3214841", "R-HSA-8943724", "R-DME-9764725", "R-CEL-9772755", "R-DME-6804760", "R-HSA-9616222", "R-HSA-2299718", "R-HSA-9701898", "R-DME-9909649", "R-DRE-9764725", "R-HSA-212436", "R-MMU-8936459", "R-MMU-6804760", "R-MMU-3214841", "R-MMU-9843940", "R-HSA-193670", "R-DME-9772755", "R-HSA-69473", "R-HSA-9830364", "R-MMU-9818564", "R-MMU-2559582", "R-HSA-9931521", "R-HSA-452723", "R-HSA-9764725", "R-HSA-9609690", "R-HSA-6804760", "R-RNO-3214841", "R-MMU-2559580", "R-RNO-6804760", "R-HSA-9710421", "R-HSA-212300", "R-DME-9843940", "R-CEL-8953750", "R-MMU-5693571", "R-DME-8943724", "R-HSA-5617472", "R-HSA-8853884", "R-DRE-6804760", "R-MMU-73762", "R-MMU-212436", "R-HSA-3769402", "R-HSA-9772755", "R-DRE-2559580", "R-HSA-9944997", "R-CEL-8936459", "R-BTA-9764725", "R-DRE-8953750", "R-DME-427359", "R-MMU-212300", "R-HSA-8953750", "R-HSA-2559582", "R-MMU-8939236", "R-DME-2559580", "R-XTR-2299718", "R-MMU-5693565", "R-HSA-9827857", "R-CEL-8943724", "R-HSA-3214841", "R-SPO-9772755", "R-HSA-9843970", "R-DDI-9772755", "R-HSA-912446", "R-RNO-212436", "R-MMU-9772755", "R-DME-8953750", "R-DRE-212300", "R-DRE-2299718", "R-DRE-9909649", "R-BTA-212300", "R-MMU-5693607", "R-HSA-9762293", "R-XTR-3214841", "R-DRE-9843940", "R-DME-212300", "R-DRE-9843970", "R-XTR-212300", "R-DME-8939236", "R-CEL-3214841", "R-HSA-73762", "R-BTA-6804760", "R-MMU-9764725", "R-DME-201722", "R-MMU-8943724", "R-XTR-8953750", "R-HSA-9931510", "R-HSA-5693571", "R-HSA-201722", "R-HSA-9931512", "R-HSA-9909649", "R-DRE-3214841", "R-DME-8936459", "R-XTR-9909649", "R-CEL-9764725", "R-HSA-9818564", "R-MMU-9909649", "R-HSA-9733709", "R-HSA-9843940", "R-XTR-2559580", "R-HSA-427389", "R-HSA-8939236"], "pathways": ["R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-2299718:r:Condensation of Prophase Chromosomes", "R-SPO-3214841:r:PKMTs methylate histone lysines", "R-BTA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-HSA-6804754:r:Regulation of TP53 Expression", "R-DME-3214841:r:PKMTs methylate histone lysines", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-212436:r:Generic Transcription Pathway", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-193670:r:p75NTR negatively regulates cell cycle via SC1", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9830364:r:Formation of the nephric duct", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9710421:r:Defective pyroptosis", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-DME-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-DRE-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-DME-427359:r:SIRT1 negatively regulates rRNA expression", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9827857:r:Specification of primordial germ cells", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DDI-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-912446:r:Meiotic recombination", "R-RNO-212436:r:Generic Transcription Pathway", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-2299718:r:Condensation of Prophase Chromosomes", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9762293:r:Regulation of CDH11 gene transcription", "R-XTR-3214841:r:PKMTs methylate histone lysines", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9733709:r:Cardiogenesis", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "type": "Homologous_superfamily"}, "IPR046342": {"description": "CBS domain superfamily", "go_ids": [], "go_terms": [], "name": "CBS_dom_sf", "pathway_ids": ["R-HSA-6802952", "R-MMU-1632852", "R-CFA-2672351", "R-MMU-6804756", "R-SCE-2672351", "R-RNO-1632852", "R-BTA-6804756", "R-SPO-200425", "R-MMU-5628897", "R-SPO-163680", "R-HSA-9613354", "R-SCE-200425", "R-RNO-1614603", "R-DDI-163680", "R-MMU-163680", "R-DDI-6798695", "R-DDI-1614603", "R-HSA-9931269", "R-SSC-380972", "R-MMU-200425", "R-RNO-5628897", "R-RNO-9931269", "R-DDI-380972", "R-HSA-2151209", "R-BTA-1632852", "R-BTA-5628897", "R-SCE-1632852", "R-HSA-6804756", "R-SSC-1632852", "R-HSA-1445148", "R-MMU-9931269", "R-RNO-380972", "R-HSA-1632852", "R-SPO-2672351", "R-SPO-1632852", "R-SPO-73817", "R-SPO-6798695", "R-HSA-9619483", "R-MMU-380972", "R-DDI-9748787", "R-SSC-5628897", "R-SCE-6798695", "R-HSA-2672351", "R-SCE-73817", "R-HSA-2408508", "R-DDI-200425", "R-HSA-5628897", "R-BTA-380972", "R-BTA-2672351", "R-RNO-2672351", "R-DDI-2672351", "R-DDI-73817", "R-MMU-2672351", "R-DME-9748787", "R-RNO-6804756", "R-SSC-9931269", "R-SSC-6804756", "R-SCE-163680", "R-HSA-380972", "R-SSC-2672351", "R-DDI-5628897", "R-SCE-9748787", "R-DDI-1632852", "R-BTA-9931269", "R-SPO-5628897", "R-DME-6798695", "R-SPO-380972", "R-HSA-1614603", "R-MMU-1614603", "R-CEL-2672351", "R-SCE-1614603", "R-SCE-380972", "R-DME-73817", "R-HSA-200425", "R-DME-2672351", "R-SPO-9748787", "R-HSA-163680"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-1632852:r:Macroautophagy", "R-CFA-2672351:r:Stimuli-sensing channels", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-2672351:r:Stimuli-sensing channels", "R-RNO-1632852:r:Macroautophagy", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-200425:r:Carnitine shuttle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-9613354:r:Lipophagy", "R-SCE-200425:r:Carnitine shuttle", "R-RNO-1614603:r:Cysteine formation from homocysteine", "R-DDI-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-1614603:r:Cysteine formation from homocysteine", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-200425:r:Carnitine shuttle", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-BTA-1632852:r:Macroautophagy", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-1632852:r:Macroautophagy", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-1632852:r:Macroautophagy", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1632852:r:Macroautophagy", "R-SPO-2672351:r:Stimuli-sensing channels", "R-SPO-1632852:r:Macroautophagy", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DDI-9748787:r:Azathioprine ADME", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2672351:r:Stimuli-sensing channels", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-DDI-200425:r:Carnitine shuttle", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-2672351:r:Stimuli-sensing channels", "R-RNO-2672351:r:Stimuli-sensing channels", "R-DDI-2672351:r:Stimuli-sensing channels", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DME-9748787:r:Azathioprine ADME", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SSC-2672351:r:Stimuli-sensing channels", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-9748787:r:Azathioprine ADME", "R-DDI-1632852:r:Macroautophagy", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-6798695:r:Neutrophil degranulation", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1614603:r:Cysteine formation from homocysteine", "R-MMU-1614603:r:Cysteine formation from homocysteine", "R-CEL-2672351:r:Stimuli-sensing channels", "R-SCE-1614603:r:Cysteine formation from homocysteine", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-200425:r:Carnitine shuttle", "R-DME-2672351:r:Stimuli-sensing channels", "R-SPO-9748787:r:Azathioprine ADME", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity"], "type": "Homologous_superfamily"}, "IPR046344": {"description": "TAF6, C-terminal HEAT repeat domain superfamily", "go_ids": ["GO:0006367"], "go_terms": ["GO:0006367:transcription initiation at RNA polymerase II promoter:P"], "name": "TAF6_C_sf", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-RNO-6807505", "R-MMU-75953", "R-SCE-75953", "R-RNO-674695", "R-DME-76042", "R-RNO-73779", "R-SPO-6807505", "R-MMU-6804756", "R-DME-73779", "R-RNO-73776", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-SCE-6807505", "R-HSA-73776", "R-HSA-75953", "R-RNO-6804756", "R-MMU-73776", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-DME-674695", "R-RNO-76042", "R-MMU-674695", "R-MMU-6807505", "R-DME-6804756", "R-SCE-76042", "R-HSA-167161", "R-DME-6807505", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-3214847", "R-HSA-76042", "R-HSA-674695", "R-SPO-73776", "R-RNO-75953", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-167161:r:HIV Transcription Initiation", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Homologous_superfamily"}, "IPR046345": {"description": "TraB/PryY-like", "go_ids": [], "go_terms": [], "name": "TraB_PrgY-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046346": {"description": "Aminoacid dehydrogenase-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Aminoacid_DH-like_N_sf", "pathway_ids": ["R-MMU-70268", "R-HSA-1989781", "R-DDI-9837999", "R-DME-196757", "R-MMU-9837999", "R-HSA-2151201", "R-DDI-8964539", "R-MMU-8964539", "R-MMU-9861718", "R-DME-9837999", "R-RNO-9837999", "R-HSA-196757", "R-MMU-2151201", "R-HSA-70268", "R-HSA-9861718", "R-HSA-8964539", "R-DME-2151201", "R-HSA-9818025", "R-RNO-70268", "R-RNO-8964539", "R-DME-8964539", 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"R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-DME-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9818025:r:NFE2L2 regulating TCA cycle genes", "R-RNO-70268:r:Pyruvate metabolism", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-DME-8964539:r:Glutamate and glutamine metabolism", "R-MMU-196757:r:Metabolism of folate and pterines", "R-RNO-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-BTA-196757:r:Metabolism of folate and pterines", "R-RNO-196757:r:Metabolism of folate and pterines", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-SSC-8964539:r:Glutamate and glutamine metabolism", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-SSC-2151201:r:Transcriptional activation of mitochondrial biogenesis"], "type": "Homologous_superfamily"}, "IPR046347": {"description": "Basic-leucine zipper domain superfamily", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "bZIP_sf", "pathway_ids": ["R-RNO-9031628", "R-CEL-9634638", "R-HSA-9022692", "R-HSA-2559580", "R-HSA-8963889", "R-CEL-442742", "R-HSA-8936459", "R-RNO-442742", "R-HSA-2871796", "R-HSA-8951664", "R-HSA-381042", "R-RNO-381033", "R-MMU-881907", "R-SCE-3214847", "R-SCE-450341", "R-BTA-8874211", "R-RNO-9018519", "R-BTA-9018519", "R-HSA-9818025", "R-DME-198693", "R-HSA-9818030", "R-DME-209409", "R-RNO-983231", "R-HSA-442720", "R-MMU-9707616", "R-RNO-375165", "R-HSA-9616222", "R-MMU-381033", "R-HSA-9708530", "R-DME-2559582", "R-HSA-381183", "R-GGA-9708530", "R-HSA-5674400", "R-HSA-983231", "R-MMU-2559582", "R-HSA-9609690", "R-RNO-9759194", "R-MMU-9031628", "R-BTA-450341", "R-RNO-8874211", "R-RNO-881907", "R-RNO-8951664", "R-GGA-2559582", "R-HSA-9031628", 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"R-DME-9634635", "R-HSA-167158", "R-MMU-75955", "R-MMU-3000170", "R-HSA-6811434", "R-HSA-73776", "R-XTR-114516", "R-BTA-77075", "R-CEL-75953", "R-MMU-1489509", "R-SPO-9634635", "R-HSA-114604", "R-DME-1433559", "R-DME-9013149", "R-BTA-75953", "R-RNO-9732724", "R-RNO-9013407", "R-DME-5675221", "R-DME-9648002", "R-HSA-167161", "R-DRE-9755511", "R-MMU-9013423", "R-HSA-1433559", "R-HSA-1295596", "R-MMU-1912408", "R-HSA-167160", "R-HSA-418597", "R-HSA-5696395", "R-HSA-5674499", "R-HSA-9726840", "R-DDI-77075", "R-HSA-9648002", "R-RNO-6798695", "R-HSA-9656223", "R-SCE-2179392", "R-RNO-9035034", "R-HSA-2672351", "R-HSA-9634635", "R-BTA-9013148", "R-CEL-73772", "R-HSA-181429", "R-BTA-6781823", "R-MMU-6781823", "R-CEL-111933", "R-MMU-73776", "R-RNO-5674499", "R-MMU-111465", "R-HSA-167172", "R-BTA-73779", "R-CEL-9013423", "R-DRE-114516", "R-DDI-2029482", "R-HSA-416993", "R-CEL-75955", "R-SPO-114508", "R-RNO-181430", "R-SPO-1169091", "R-SCE-9013106", "R-HSA-73863", "R-SPO-73772", "R-SCE-5218921", "R-GGA-5674499", "R-HSA-877300", "R-RNO-5696400", "R-DDI-9013404", "R-MMU-9013149", "R-RNO-3000170", "R-MMU-373752", "R-HSA-9013422", "R-HSA-5674135", "R-SCE-75953", "R-MMU-113418", "R-DME-5621575", "R-SCE-2029485", "R-BTA-76042", "R-RNO-9013149", "R-RNO-73863", "R-HSA-2179392", "R-HSA-9013424", "R-DRE-5218921", "R-MMU-9013404", "R-MMU-1295596", "R-HSA-3928662", "R-MMU-9013422", "R-RNO-2029485", "R-RNO-2179392", "R-RNO-9013424", "R-BTA-392517", "R-CEL-264642", "R-MMU-420029", "R-HSA-2514859", "R-MMU-8853659", "R-CEL-76005", "R-MMU-450520", "R-CEL-113418", "R-CEL-202424", "R-DME-9755511", "R-HSA-9013404", "R-MMU-264642", "R-MMU-9634635", "R-MMU-2871837", "R-RNO-264642", "R-MMU-6782210", "R-RNO-4419969", "R-CEL-6796648", "R-RNO-4420097", "R-HSA-114516", "R-MMU-73762", "R-DME-1169091", "R-MMU-6782135", "R-RNO-111933", "R-BTA-114516", "R-HSA-399997", "R-CEL-9013149", "R-DME-209214", "R-HSA-167162", "R-SCE-9634635", "R-RNO-373752", "R-BTA-5696395", "R-RNO-9648002", "R-SCE-6782210", "R-BTA-6796648", "R-MMU-73863", "R-HSA-6782135", "R-HSA-9679191", "R-MMU-8985586", "R-HSA-1660661", "R-HSA-1433557", "R-MMU-877300", "R-DDI-5621575", "R-HSA-8985586", "R-BTA-5218921", "R-MMU-9013026", "R-DDI-168638", "R-MMU-4419969", "R-RNO-1250196", "R-DDI-75953", "R-CEL-76042", "R-HSA-5627117", "R-HSA-5675221", "R-CEL-73779", "R-GGA-9732724", "R-HSA-73772", "R-SPO-674695", "R-MMU-75953", "R-CEL-181430", "R-HSA-6802952", "R-HSA-420029", "R-HSA-9732724", "R-RNO-73776", "R-DDI-389359", "R-GGA-5675221", "R-BTA-1169091", "R-MMU-9732724", "R-DME-2029485", "R-RNO-193648", "R-HSA-170984", "R-MMU-6811434", "R-BTA-75955", "R-MMU-9035034", "R-BTA-5099900", "R-MMU-392517", "R-MMU-5625900", "R-RNO-5696395", "R-MMU-5673000", "R-RNO-9013148", "R-CEL-5674135", "R-CEL-212676", "R-RNO-209543", "R-DDI-5674135", "R-CEL-112382", "R-CEL-6782135", "R-MMU-399997", "R-DRE-9013026", "R-BTA-8980692", "R-BTA-6782210", "R-MMU-9696264", "R-SPO-73776", "R-MMU-354192", "R-GGA-5673000", "R-HSA-392517", "R-DDI-5696395", "R-RNO-8980692", "R-CEL-2179392", "R-RNO-1489509", "R-SPO-5625740", "R-CEL-9748787", "R-RNO-416482", "R-DDI-6796648", "R-MMU-2132295", "R-BTA-76005", "R-RNO-3928662", "R-CEL-9013406", "R-HSA-6782210", "R-RNO-8985586", "R-SPO-399997", "R-RNO-5627117", "R-MMU-114508", "R-MMU-6796648", "R-DRE-420029", "R-HSA-3000170", "R-RNO-6796648", "R-RNO-210500", "R-HSA-5099900", "R-BTA-674695", "R-DDI-5675221", "R-CEL-2672351", "R-HSA-75955", "R-HSA-170968", "R-CEL-114604", "R-SCE-73772", "R-RNO-416993", "R-RNO-877300", "R-MMU-1433559", "R-CEL-8980692", "R-RNO-674695", "R-MMU-9013106", "R-CEL-5099900", "R-MMU-5099900", "R-CEL-4419969", "R-RNO-416572", "R-SPO-202424", "R-HSA-6796648", "R-MMU-416572", "R-DDI-170968", "R-CEL-1169091", "R-HSA-167246", "R-MMU-5696395", "R-XTR-5099900", "R-DDI-9013423", "R-DRE-76005", "R-RNO-5673001", "R-DRE-5668599", "R-DME-5673000", "R-RNO-6782210", "R-SPO-113418", "R-BTA-114508", "R-MMU-1433557", "R-MMU-5621575", "R-MMU-209543", "R-DRE-416993", "R-DDI-6781823", "R-HSA-450520", "R-HSA-2029482", "R-XTR-5218921", "R-HSA-5218921", "R-SPO-8980692", "R-GGA-430116", "R-CEL-6781823", "R-BTA-5668599", "R-HSA-4419969", "R-CEL-5674499", "R-MMU-9013406", "R-MMU-6798695", "R-BTA-354192", "R-RNO-75953", "R-SCE-6782135", "R-BTA-113418", "R-RNO-450520", "R-MMU-9755511", "R-DME-430116", "R-RNO-1912408", "R-RNO-2029482", "R-RNO-5668599", "R-HSA-2871837", "R-HSA-1169092", "R-HSA-5621575", "R-DME-9013406", "R-DRE-9013149", "R-CEL-181429", "R-RNO-114508", "R-DME-209190", "R-RNO-72086", "R-DME-170968", "R-CEL-5675221", "R-HSA-2173791", "R-RNO-76005", "R-DRE-9013148", "R-HSA-3928663", "R-RNO-5607764", "R-CEL-4420097", "R-GGA-2672351", "R-SCE-77075", "R-MMU-416482", "R-DME-114516", "R-SPO-6782135", "R-HSA-9664422", "R-SCE-202424", "R-CEL-5218920", "R-RNO-6781823", "R-HSA-9013409", "R-SPO-2029485", "R-HSA-427413", "R-HSA-1489509", "R-RNO-1433559", "R-DME-5218921", "R-MMU-112382", "R-RNO-111465", "R-SPO-76042", "R-HSA-5673000", "R-DDI-5213460", "R-HSA-8853659", "R-DDI-674695", "R-SPO-5668599", "R-DDI-5673000", "R-DME-1295596", "R-CEL-3000170", "R-DDI-445144", "R-MMU-5673001", "R-HSA-210500", "R-BTA-73863", "R-RNO-5673000", "R-HSA-181430", "R-BTA-6782135", "R-HSA-416482", "R-CEL-6782210", "R-SPO-9013148", "R-CEL-9648002", "R-HSA-9696264", "R-GGA-5674135", "R-CEL-5696395", "R-MMU-193648", "R-HSA-111933", "R-HSA-9013026", "R-RNO-9696264", "R-MMU-73772", "R-CEL-170968", "R-BTA-73776", "R-HSA-212676", "R-BTA-73772", "R-DME-373752", "R-MMU-5675221", "R-SCE-73776", "R-HSA-5625900", "R-HSA-416572", "R-HSA-6781827", "R-MMU-430116", "R-MMU-8980692", "R-CEL-1489509", "R-SCE-6798695", "R-HSA-2029485", "R-MMU-983189", "R-HSA-9013106", "R-DME-114508", "R-CEL-5607764", "R-SPO-5218921", "R-RNO-399997", "R-DRE-1912408", "R-HSA-9013423", "R-DME-392517", "R-SSC-5674135", "R-CEL-373752", "R-HSA-1250196", "R-HSA-4086398", "R-BTA-5696400", "R-CEL-193648", "R-MMU-202424", "R-SCE-5625740", "R-RNO-113418", "R-DDI-5687128", "R-MMU-212676", "R-DDI-392517", "R-MMU-1169091", "R-CEL-430116", "R-HSA-9726842", "R-CEL-3928665", "R-XTR-354192", "R-RNO-77075", "R-DDI-3928662", "R-HSA-111465", "R-HSA-5696400", "R-HSA-112382", "R-HSA-73779", "R-MMU-5607764", "R-HSA-430116", "R-CEL-912631", "R-CEL-416482", "R-HSA-4420097", "R-SPO-9013106", "R-RNO-392517", "R-DME-111465", "R-SCE-5607764", "R-HSA-9649948", "R-CEL-114508", "R-CEL-1433559", "R-MMU-5668599", "R-RNO-202424", "R-XTR-1169092", "R-RNO-9013406", "R-XTR-392517", "R-CEL-9013148", "R-MMU-73779", "R-MMU-76042", "R-SCE-9856530", "R-SPO-75953", "R-SPO-5607764", "R-RNO-8853659", "R-RNO-76042", "R-HSA-9755511", "R-DDI-72086", "R-DME-2173791", "R-GGA-5621575", "R-RNO-420029", "R-MMU-111933", "R-MMU-674695", "R-DME-399997", "R-HSA-9013149", "R-HSA-1169091", "R-HSA-8980692", "R-SCE-674695", "R-SPO-9013424", "R-RNO-181429", "R-SPO-2179392", "R-MMU-1169092", "R-RNO-430116", "R-SPO-1489509", "R-HSA-209543", "R-CEL-72086", "R-HSA-72086", "R-DDI-9013149", "R-HSA-1912408", "R-SCE-1169091", "R-RNO-2672351", "R-HSA-6802946", "R-HSA-167152", "R-DRE-5099900", "R-RNO-9013106", "R-CEL-1660661", "R-RNO-5099900", "R-HSA-5607764", "R-DME-1489509", "R-DME-4419969", "R-HSA-354192", "R-SCE-6796648", "R-MMU-416993", "R-HSA-193648", "R-SPO-77075", "R-RNO-73772", "R-CEL-392517", "R-RNO-6782135", "R-SCE-113418", "R-RNO-9634635", "R-MMU-181429", "R-RNO-5625900", "R-RNO-5218921", "R-SPO-5696400", "R-DDI-114508", "R-SCE-5668599", "R-HSA-8939246", "R-SCE-2871837", "R-XTR-1169091"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-170968:r:Frs2-mediated activation", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-373752:r:Netrin-1 signaling", "R-SCE-1489509:r:DAG and IP3 signaling", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-DRE-8980692:r:RHOA GTPase cycle", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-MMU-72086:r:mRNA Capping", "R-DME-5674499:r:Negative feedback regulation of MAPK pathway", "R-SSC-114508:r:Effects of PIP2 hydrolysis", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-DME-111933:r:Calmodulin induced events", "R-XTR-4419969:r:Depolymerization of the Nuclear Lamina", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-SCE-76005:r:Response to elevated platelet cytosolic Ca2+", "R-SPO-114516:r:Disinhibition of SNARE formation", "R-XTR-5673001:r:RAF/MAP kinase cascade", "R-RNO-354192:r:Integrin signaling", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-SCE-4419969:r:Depolymerization of the Nuclear Lamina", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-114516:r:Disinhibition of SNARE formation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-9013424:r:RHOV GTPase cycle", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-392517:r:Rap1 signalling", "R-DME-6798695:r:Neutrophil degranulation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-SPO-2871837:r:FCERI mediated NF-kB activation", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-76005:r:Response to elevated platelet cytosolic Ca2+", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-2871837:r:FCERI mediated NF-kB activation", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-72086:r:mRNA Capping", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-DME-5674135:r:MAP2K and MAPK activation", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-1912408:r:Pre-NOTCH Transcription and Translation", "R-BTA-72086:r:mRNA Capping", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-DME-76005:r:Response to elevated platelet cytosolic Ca2+", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DDI-6782135:r:Dual incision in TC-NER", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-RNO-114516:r:Disinhibition of SNARE formation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-MMU-9648002:r:RAS processing", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-XTR-5668599:r:RHO GTPases 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interaction with CE", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-DME-114516:r:Disinhibition of SNARE formation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SCE-202424:r:Downstream TCR signaling", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-1489509:r:DAG and IP3 signaling", "R-RNO-1433559:r:Regulation of KIT signaling", "R-DME-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-5673000:r:RAF activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-8853659:r:RET signaling", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DDI-5673000:r:RAF activation", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-CEL-3000170:r:Syndecan interactions", "R-DDI-445144:r:Signal transduction by L1", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-BTA-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5673000:r:RAF activation", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-BTA-6782135:r:Dual incision in TC-NER", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-CEL-9648002:r:RAS processing", "R-HSA-9696264:r:RND3 GTPase cycle", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-111933:r:Calmodulin induced events", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-170968:r:Frs2-mediated activation", "R-BTA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-DME-373752:r:Netrin-1 signaling", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-MMU-8980692:r:RHOA GTPase cycle", "R-CEL-1489509:r:DAG and IP3 signaling", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-983189:r:Kinesins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-DRE-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-392517:r:Rap1 signalling", "R-SSC-5674135:r:MAP2K and MAPK activation", "R-CEL-373752:r:Netrin-1 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-4086398:r:Ca2+ pathway", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-CEL-193648:r:NRAGE signals death through JNK", "R-MMU-202424:r:Downstream TCR signaling", "R-SCE-5625740:r:RHO GTPases activate PKNs", "R-RNO-113418:r:Formation of the Early Elongation Complex", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-DDI-392517:r:Rap1 signalling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-XTR-354192:r:Integrin signaling", "R-RNO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-DDI-3928662:r:EPHB-mediated forward signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-CEL-912631:r:Regulation of signaling by CBL", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-SPO-9013106:r:RHOC GTPase cycle", "R-RNO-392517:r:Rap1 signalling", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-SCE-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-CEL-114508:r:Effects of PIP2 hydrolysis", "R-CEL-1433559:r:Regulation of KIT signaling", "R-MMU-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-RNO-202424:r:Downstream TCR signaling", "R-XTR-1169092:r:Activation of RAS in B cells", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-XTR-392517:r:Rap1 signalling", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-8853659:r:RET signaling", "R-RNO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-72086:r:mRNA Capping", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-420029:r:Tight junction interactions", "R-MMU-111933:r:Calmodulin induced events", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-9013424:r:RHOV GTPase cycle", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-SPO-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-1169092:r:Activation of RAS in B cells", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-SPO-1489509:r:DAG and IP3 signaling", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-SCE-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DRE-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-9013106:r:RHOC GTPase cycle", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-1489509:r:DAG and IP3 signaling", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-354192:r:Integrin signaling", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-193648:r:NRAGE signals death through JNK", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-392517:r:Rap1 signalling", "R-RNO-6782135:r:Dual incision in TC-NER", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-RNO-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-DDI-114508:r:Effects of PIP2 hydrolysis", "R-SCE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-SCE-2871837:r:FCERI mediated NF-kB activation", "R-XTR-1169091:r:Activation of NF-kappaB in B cells"], "type": "Homologous_superfamily"}, "IPR046350": {"description": "Cystatin superfamily", "go_ids": [], "go_terms": [], "name": "Cystatin_sf", "pathway_ids": ["R-HSA-6798695", "R-SSC-6798695", "R-HSA-6809371", "R-BTA-6803157", "R-HSA-375276", "R-CEL-6798695", "R-HSA-140837", "R-HSA-977225", "R-BTA-6798695", "R-HSA-416476", "R-MMU-8957275", "R-RNO-114608", "R-RNO-418594", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-114608", "R-RNO-8957275", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-BTA-381426", "R-HSA-6803157", "R-MMU-6803157", "R-RNO-75205", "R-RNO-416476", "R-HSA-75205", "R-HSA-381426", "R-DDI-6798695", "R-DME-114608", "R-MMU-75205", "R-GGA-6798695", "R-RNO-381426", "R-HSA-418594", "R-GGA-6803157", "R-MMU-6809371", "R-RNO-375276", "R-SSC-6809371", "R-DME-2132295", "R-MMU-6798695", "R-HSA-8957275", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-BTA-6803157:r:Antimicrobial peptides", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-977225:r:Amyloid fiber formation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6803157:r:Antimicrobial peptides", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-114608:r:Platelet degranulation", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-418594:r:G alpha (i) signalling events", "R-GGA-6803157:r:Antimicrobial peptides", "R-MMU-6809371:r:Formation of the cornified envelope", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-SSC-6809371:r:Formation of the cornified envelope", "R-DME-2132295:r:MHC class II antigen presentation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Homologous_superfamily"}, "IPR046351": {"description": "U3 small nucleolar RNA-associated protein 4", "go_ids": ["GO:0030686", "GO:0000462"], "go_terms": ["GO:0030686:90S preribosome:C", "GO:0000462:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA):P"], "name": "UTP4", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR046354": {"description": "Sperm acrosome membrane-associated protein 4/Protein Bouncer", "go_ids": [], "go_terms": [], "name": "SPACA4/Bouncer", "pathway_ids": ["R-BTA-163125", "R-MMU-163125", "R-HSA-163125"], "pathways": ["R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR046355": {"description": "GRB2-associated-binding protein 1-4-like", "go_ids": [], "go_terms": [], "name": "Gab1-4-like", "pathway_ids": ["R-HSA-9607240", "R-HSA-8875555", "R-MMU-9607240", "R-HSA-180292", "R-MMU-9674555", "R-MMU-5654720", "R-MMU-6811558", "R-BTA-8851907", "R-RNO-9607240", "R-BTA-1963642", "R-BTA-5654710", "R-MMU-8865999", "R-RNO-912526", "R-HSA-5654695", "R-MMU-5654695", "R-RNO-6811558", "R-HSA-8853659", "R-BTA-8853659", "R-BTA-6811558", "R-BTA-8875656", "R-HSA-9664565", "R-HSA-5655302", "R-MMU-1433557", "R-HSA-5654689", "R-MMU-180292", "R-RNO-8853659", "R-DME-109704", "R-MMU-8853659", "R-HSA-2219530", "R-HSA-8983432", "R-HSA-5637810", "R-HSA-6811558", "R-RNO-1433557", "R-MMU-8875555", "R-DME-5654710", "R-MMU-912526", "R-DME-8853659", "R-HSA-9703648", "R-DME-5654695", "R-HSA-5654720", "R-BTA-8875555", "R-DME-1257604", "R-RNO-2730905", "R-MMU-1963642", "R-MMU-9027276", "R-MMU-2730905", "R-HSA-9674555", "R-HSA-1257604", "R-DME-1963642", "R-BTA-5654689", "R-MMU-5654710", "R-HSA-8865999", "R-HSA-9680350", "R-HSA-1839117", "R-BTA-8865999", "R-HSA-5655253", "R-RNO-9674555", "R-DME-5654720", "R-RNO-1257604", "R-BTA-5654720", "R-RNO-109704", "R-HSA-9665348", "R-DME-6811558", "R-BTA-5654695", "R-HSA-8851907", "R-HSA-1236382", "R-HSA-9028335", "R-HSA-1963642", "R-HSA-2730905", "R-HSA-9027276", "R-DME-180292", "R-HSA-5655291", "R-BTA-180292", "R-MMU-109704", "R-HSA-5655332", "R-HSA-9645135", "R-HSA-109704", "R-DME-5654689", "R-MMU-1257604", "R-HSA-1433557", "R-DME-2730905", "R-HSA-9703465", "R-BTA-109704", "R-MMU-8851907", "R-MMU-8875656", "R-BTA-1257604", "R-HSA-5654710", "R-HSA-912526", "R-BTA-9027276", "R-HSA-8875656", "R-MMU-5654689", "R-HSA-9702518"], "pathways": ["R-HSA-9607240:r:FLT3 Signaling", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-9607240:r:FLT3 Signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-8851907:r:MET activates PI3K/AKT signaling", "R-RNO-9607240:r:FLT3 Signaling", "R-BTA-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-5654710:r:PI-3K cascade:FGFR3", "R-MMU-8865999:r:MET activates PTPN11", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-BTA-8853659:r:RET signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-8875656:r:MET receptor recycling", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-MMU-180292:r:GAB1 signalosome", "R-RNO-8853659:r:RET signaling", "R-DME-109704:r:PI3K Cascade", "R-MMU-8853659:r:RET signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-8983432:r:Interleukin-15 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-DME-5654710:r:PI-3K cascade:FGFR3", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DME-8853659:r:RET signaling", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-HSA-5654720:r:PI-3K cascade:FGFR4", "R-BTA-8875555:r:MET activates RAP1 and RAC1", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-BTA-5654689:r:PI-3K cascade:FGFR1", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-HSA-8865999:r:MET activates PTPN11", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-BTA-8865999:r:MET activates PTPN11", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-DME-5654720:r:PI-3K cascade:FGFR4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-BTA-5654720:r:PI-3K cascade:FGFR4", "R-RNO-109704:r:PI3K Cascade", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-BTA-5654695:r:PI-3K cascade:FGFR2", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-HSA-9028335:r:Activated NTRK2 signals through PI3K", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-DME-180292:r:GAB1 signalosome", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-BTA-180292:r:GAB1 signalosome", "R-MMU-109704:r:PI3K Cascade", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-HSA-9645135:r:STAT5 Activation", "R-HSA-109704:r:PI3K Cascade", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-DME-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-109704:r:PI3K Cascade", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-8875656:r:MET receptor recycling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-8875656:r:MET receptor recycling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants"], "type": "Family"}, "IPR046356": {"description": "E3 ubiquitin-protein ligase MARCHF4/9/11", "go_ids": ["GO:0004842", "GO:0016567"], "go_terms": ["GO:0004842:ubiquitin-protein transferase activity:F", "GO:0016567:protein ubiquitination:P"], "name": "MARCHF4/9/11", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR046357": {"description": "Peptidyl-prolyl cis-trans isomerase domain superfamily", 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"R-RNO-3371568", "R-HSA-2025928", "R-RNO-2672351", "R-HSA-166208", "R-BTA-936440", "R-MMU-2672351", "R-RNO-2025928", "R-DME-166208", "R-BTA-5578775", "R-HSA-5578775", "R-HSA-3371568", "R-RNO-2173789", "R-PFA-3371497", "R-HSA-8937144", "R-HSA-381038", "R-MMU-2173789", "R-HSA-390471", "R-BTA-166208", "R-HSA-2173791", "R-RNO-5578775", "R-DME-6811555", "R-DDI-166208", "R-HSA-9760173", "R-HSA-9679191", "R-HSA-6811555", "R-BTA-6811555", "R-SCE-6811555", "R-HSA-9692916", "R-MMU-166208", "R-HSA-9022699", "R-HSA-5602498", "R-MMU-6811555", "R-MMU-936440", "R-DME-8939211", "R-SCE-5668599", "R-BTA-2025928", "R-RNO-8939211", "R-HSA-5668599", "R-DDI-2025928"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-2025928:r:Calcineurin activates 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"R-DRE-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "type": "Domain"}, "IPR046361": {"description": "Exocyst complex subunit EXOC6/Sec15, C-terminal", "go_ids": [], "go_terms": [], "name": "EXOC6/Sec15_C", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", 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["R-RNO-264876", "R-HSA-5620916", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Domain"}, "IPR046365": {"description": "FAM124 domain", "go_ids": [], "go_terms": [], "name": "FAM124_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046366": {"description": "ER-bound oxygenase mpaB/B'", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "MPAB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046367": {"description": "GapR-like, DNA-binding domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "GapR-like_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046368": {"description": "Tag1", "go_ids": ["GO:0000329"], "go_terms": ["GO:0000329:fungal-type vacuole membrane:C"], "name": "Tag1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046369": {"description": "Mastermind-like 1-3", "go_ids": ["GO:0003713", "GO:0007221"], "go_terms": ["GO:0003713:transcription coactivator activity:F", "GO:0007221:positive regulation of transcription of Notch receptor target:P"], "name": "MAML1-3", "pathway_ids": ["R-HSA-9013508", "R-HSA-8941856", "R-HSA-210744", "R-MMU-2122947", "R-HSA-2894862", "R-HSA-350054", "R-HSA-1912408", "R-HSA-9013695", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-2122947"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Family"}, "IPR046370": {"description": "Neurogenic mastermind-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "MAML_N_sf", "pathway_ids": ["R-HSA-9013508", "R-HSA-8941856", "R-HSA-210744", "R-MMU-2122947", "R-HSA-2894862", "R-HSA-350054", "R-HSA-1912408", "R-HSA-9013695", "R-MMU-350054", "R-MMU-8941856", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-2197563", "R-HSA-2122947"], "pathways": ["R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Homologous_superfamily"}, "IPR046371": {"description": "Bcl-2, Bcl-2 homology region 1-3", "go_ids": [], "go_terms": [], "name": "Bcl-2_BH1-3", "pathway_ids": ["R-HSA-114294", "R-MMU-9648002", "R-MMU-844455", "R-HSA-5620971", "R-BTA-6804114", "R-RNO-844455", "R-RNO-6804114", "R-MMU-111452", "R-MMU-111453", "R-RNO-111453", "R-BTA-114294", "R-HSA-9818030", "R-HSA-111453", "R-BTA-5620971", "R-RNO-5620971", "R-MMU-111457", "R-BTA-111457", "R-HSA-8878166", "R-RNO-9648002", "R-HSA-9824594", "R-HSA-844455", "R-HSA-9018519", "R-HSA-9692913", "R-HSA-9603505", "R-HSA-9702518", "R-HSA-111447", "R-HSA-6785807", "R-HSA-9634638", "R-GGA-844455", "R-CEL-9648002", "R-RNO-111457", "R-HSA-9725371", "R-MMU-111447", "R-HSA-111457", "R-HSA-111452", "R-RNO-114294", "R-HSA-6804114", "R-HSA-6803204", "R-GGA-111453", "R-MMU-5620971", "R-CEL-111453", "R-MMU-114294", "R-HSA-9648002", "R-HSA-9725370", "R-MMU-6804114"], "pathways": ["R-HSA-114294:r:Activation, translocation and oligomerization of BAX", "R-MMU-9648002:r:RAS processing", "R-MMU-844455:r:The NLRP1 inflammasome", "R-HSA-5620971:r:Pyroptosis", "R-BTA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-844455:r:The NLRP1 inflammasome", "R-RNO-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-111452:r:Activation and oligomerization of BAK protein", "R-MMU-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-RNO-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-BTA-114294:r:Activation, translocation and oligomerization of BAX", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-HSA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-BTA-5620971:r:Pyroptosis", "R-RNO-5620971:r:Pyroptosis", "R-MMU-111457:r:Release of apoptotic factors from the mitochondria", "R-BTA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-RNO-9648002:r:RAS processing", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-844455:r:The NLRP1 inflammasome", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9692913:r:SARS-CoV-1-mediated effects on programmed cell death", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-GGA-844455:r:The NLRP1 inflammasome", "R-CEL-9648002:r:RAS processing", "R-RNO-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-111447:r:Activation of BAD and translocation to mitochondria", "R-HSA-111457:r:Release of apoptotic factors from the mitochondria", "R-HSA-111452:r:Activation and oligomerization of BAK protein", "R-RNO-114294:r:Activation, translocation and oligomerization of BAX", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-GGA-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-MMU-5620971:r:Pyroptosis", "R-CEL-111453:r:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "R-MMU-114294:r:Activation, translocation and oligomerization of BAX", "R-HSA-9648002:r:RAS processing", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "type": "Domain"}, "IPR046372": {"description": "Poly (ADP-ribose) glycohydrolase (PARG), catalytic domain", "go_ids": ["GO:0006282", "GO:0004649"], "go_terms": ["GO:0006282:regulation of DNA repair:P", "GO:0004649:poly(ADP-ribose) glycohydrolase activity:F"], "name": "PARG_cat_C", "pathway_ids": ["R-HSA-110362", "R-MMU-110362", "R-RNO-110362"], "pathways": ["R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair"], "type": "Domain"}, "IPR046373": {"description": "Acyl-CoA oxidase/dehydrogenase, middle domain superfamily", "go_ids": ["GO:0016627"], "go_terms": ["GO:0016627:oxidoreductase activity, acting on the CH-CH group of donors:F"], "name": "Acyl-CoA_Oxase/DH_mid-dom_sf", "pathway_ids": ["R-HSA-1989781", "R-DDI-390247", "R-CEL-71064", "R-HSA-6799198", "R-RNO-6799198", "R-RNO-2046106", "R-DME-77288", "R-DDI-71064", "R-HSA-77346", "R-MMU-77352", "R-RNO-77305", "R-BTA-9033241", "R-CEL-2046106", "R-RNO-9033241", "R-MMU-77346", "R-MMU-389887", "R-DME-77348", "R-RNO-77285", "R-RNO-389887", "R-DDI-193368", "R-RNO-77289", "R-BTA-9837999", "R-HSA-71064", "R-HSA-77352", "R-DDI-9033241", "R-HSA-77289", "R-DME-77346", "R-BTA-70895", "R-MMU-6799198", "R-MMU-77350", "R-DME-389887", "R-HSA-389887", "R-HSA-70895", "R-HSA-77348", "R-BTA-2046106", "R-MMU-77348", "R-BTA-77305", "R-HSA-77310", "R-BTA-77346", "R-SSC-77285", "R-HSA-390247", "R-MMU-77289", "R-RNO-193368", "R-MMU-390247", "R-HSA-2046106", "R-MMU-77288", "R-RNO-77352", "R-MMU-9837999", "R-RNO-77346", "R-HSA-77288", "R-DDI-70895", "R-RNO-77310", "R-HSA-193368", "R-HSA-77350", "R-DME-2046106", "R-HSA-77285", "R-BTA-77288", "R-CEL-193368", "R-SSC-77310", "R-RNO-77350", "R-RNO-77288", "R-DDI-389887", "R-MMU-70895", "R-MMU-77310", "R-RNO-77348", "R-HSA-9837999", "R-HSA-77305", "R-CEL-389887", "R-DME-390247", "R-BTA-71064", "R-DDI-9837999", "R-HSA-381038", "R-MMU-71064", "R-MMU-2046106", "R-MMU-193368", "R-DDI-2046106", "R-DME-9033241", "R-MMU-9033241", "R-RNO-9837999", "R-CEL-390247", "R-MMU-77285", "R-BTA-77348", "R-RNO-70895", "R-SCE-389887", "R-MMU-77305", "R-DME-193368", "R-BTA-390247", "R-HSA-9033500", "R-HSA-9033241", "R-HSA-9914355", "R-RNO-390247"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-71064:r:Lysine catabolism", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-71064:r:Lysine catabolism", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-BTA-9033241:r:Peroxisomal protein import", "R-CEL-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-71064:r:Lysine catabolism", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-6799198:r:Complex I biogenesis", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-BTA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-BTA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-CEL-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-DDI-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-CEL-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-BTA-71064:r:Lysine catabolism", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-71064:r:Lysine catabolism", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-9033241:r:Peroxisomal protein import", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-CEL-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-BTA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-70895:r:Branched-chain amino acid catabolism", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-9033241:r:Peroxisomal protein import", "R-HSA-9914355:r:Isovaleric acidemia", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Homologous_superfamily"}, "IPR046375": {"description": "IKBKB, scaffold dimerization domain superfamily", "go_ids": [], "go_terms": [], "name": "IKBKB_SDD_sf", "pathway_ids": ["R-BTA-9909505", "R-MMU-9909505", "R-HSA-9020702", "R-RNO-9758274", "R-DRE-1169091", "R-RNO-9020702", "R-HSA-168638", "R-MMU-5607764", "R-HSA-9833482", "R-XTR-5357905", "R-XTR-5607764", "R-MMU-198323", "R-BTA-202424", "R-MMU-9020702", "R-XTR-202424", "R-HSA-5676590", "R-BTA-975144", "R-RNO-5357905", "R-MMU-933542", "R-DRE-198323", "R-DRE-445989", "R-MMU-9833482", "R-HSA-5684264", "R-MMU-445989", "R-BTA-9758274", "R-HSA-168927", "R-BTA-1169091", "R-XTR-5607761", "R-MMU-1810476", "R-BTA-937041", "R-RNO-202424", "R-HSA-937041", "R-DRE-9020702", "R-BTA-5607761", "R-GGA-1227892", "R-MMU-5684264", "R-HSA-5603029", "R-HSA-5607761", "R-MMU-975144", "R-XTR-5684264", "R-HSA-209560", "R-BTA-5357905", "R-MMU-209543", "R-HSA-975144", "R-HSA-5674400", "R-RNO-975144", "R-RNO-209560", "R-HSA-9758274", "R-GGA-434131", "R-BTA-5684264", "R-MMU-9860276", "R-HSA-5602636", "R-RNO-209543", "R-HSA-9860276", "R-HSA-1169091", "R-DRE-5357905", "R-DRE-5684264", "R-BTA-1810476", "R-MMU-2871837", "R-BTA-933542", "R-MMU-5357905", "R-RNO-445989", "R-HSA-1236974", "R-DRE-5607761", "R-HSA-9860927", "R-BTA-937039", "R-BTA-9833482", "R-DRE-937039", "R-MMU-9860927", "R-RNO-933542", "R-HSA-445989", "R-HSA-9705671", "R-RNO-9860276", "R-BTA-5357956", "R-RNO-9833482", "R-HSA-209543", "R-HSA-933542", "R-RNO-9909505", "R-MMU-5357956", "R-BTA-5676590", "R-DRE-9833482", "R-HSA-9909505", "R-HSA-198323", "R-RNO-9860927", "R-HSA-2871837", "R-BTA-2871837", "R-HSA-5357905", "R-MMU-937039", "R-BTA-209543", "R-BTA-445989", "R-DRE-5676590", "R-XTR-445989", "R-HSA-5607764", "R-BTA-209560", "R-XTR-9758274", "R-RNO-1810476", "R-MMU-202424", "R-RNO-937039", "R-RNO-937041", "R-XTR-2871837", "R-GGA-1227739", "R-RNO-2871837", "R-MMU-209560", "R-RNO-5684264", "R-BTA-9860276", "R-MMU-1169091", "R-GGA-434001", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-1810476", "R-BTA-9860927", "R-XTR-9833482", "R-HSA-5603027", "R-DRE-975144", "R-HSA-5357956", "R-RNO-5607764", "R-RNO-1169091", "R-HSA-933543", "R-BTA-9020702", "R-BTA-5607764", "R-RNO-5357956", "R-MMU-9758274", "R-HSA-202424", "R-MMU-937041", "R-DRE-9758274", "R-HSA-937039", "R-XTR-5676590", "R-XTR-1169091"], "pathways": ["R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9833482:r:PKR-mediated signaling", "R-XTR-5357905:r:Regulation of TNFR1 signaling", "R-XTR-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-XTR-202424:r:Downstream TCR signaling", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-DRE-198323:r:AKT phosphorylates targets in the cytosol", "R-DRE-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-XTR-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-DRE-9020702:r:Interleukin-1 signaling", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5603029:r:IkBA variant leads to EDA-ID", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-XTR-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-5602636:r:IKBKB deficiency causes SCID", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-BTA-9833482:r:PKR-mediated signaling", "R-DRE-937039:r:IRAK1 recruits IKK complex", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-9833482:r:PKR-mediated signaling", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-XTR-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-GGA-1227739:r:Caspase-8 and -10 mediated induction of NF-kB", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-XTR-9833482:r:PKR-mediated signaling", "R-HSA-5603027:r:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "R-DRE-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-DRE-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-XTR-5676590:r:NIK-->noncanonical NF-kB signaling", "R-XTR-1169091:r:Activation of NF-kappaB in B cells"], "type": "Homologous_superfamily"}, "IPR046377": {"description": "DWD HYPERSENSITIVE TO UV-B 1", "go_ids": ["GO:0071493", "GO:0080008"], "go_terms": ["GO:0071493:cellular response to UV-B:P", "GO:0080008:Cul4-RING E3 ubiquitin ligase complex:C"], "name": "DHU1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046378": {"description": "Daxx, histone-binding domain", "go_ids": [], "go_terms": [], "name": "DAXX_histone-bd", "pathway_ids": ["R-RNO-6804757", "R-MMU-3899300", "R-CFA-9670095", "R-HSA-6804757", "R-HSA-9670095", "R-CFA-6804757", "R-MMU-6804757", "R-HSA-9670613", "R-HSA-9670615", "R-HSA-9920951", "R-HSA-3899300", "R-HSA-9609690", "R-RNO-3899300", "R-MMU-9670095"], "pathways": ["R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-CFA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-9670613:r:Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations", "R-HSA-9670615:r:Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere"], "type": "Domain"}, "IPR046383": {"description": "N6-succino-2-amino-2'-deoxyadenylate synthase", "go_ids": ["GO:0006164", "GO:0005524"], "go_terms": ["GO:0006164:purine nucleotide biosynthetic process:P", "GO:0005524:ATP binding:F"], "name": "Phage_PurZ", "pathway_ids": ["PWY-8289"], "pathways": ["PWY-8289:t:dZTP biosynthesis"], "type": "Family"}, "IPR046385": {"description": "Cell division protein DrpB", "go_ids": ["GO:0051301"], "go_terms": ["GO:0051301:cell division:P"], "name": "DrpB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046391": {"description": "Protein spackle", "go_ids": ["GO:0098669"], "go_terms": ["GO:0098669:superinfection exclusion:P"], "name": "SPACKLE_T4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046399": {"description": "DNA-directed RNA polymerase subunit Rpo7", "go_ids": ["GO:0000428", "GO:0006351"], "go_terms": ["GO:0000428:DNA-directed RNA polymerase complex:C", "GO:0006351:DNA-templated transcription:P"], "name": "RNApol_Rpo7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046403": {"description": "3-oxopimeloyl-[acyl-carrier-protein] synthase", "go_ids": ["GO:0009102", "GO:0004315"], "go_terms": ["GO:0009102:biotin biosynthetic process:P", "GO:0004315:3-oxoacyl-[acyl-carrier-protein] synthase activity:F"], "name": "BioZ", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR046405": {"description": "Guanosine-inosine kinase", "go_ids": ["GO:0006166", "GO:0106366", "GO:0008906"], "go_terms": ["GO:0006166:purine ribonucleoside salvage:P", "GO:0106366:guanosine kinase activity:F", "GO:0008906:inosine kinase activity:F"], "name": "IngK", "pathway_ids": ["PWY-6611", "PWY-6618"], "pathways": ["PWY-6611:t:adenine and adenosine salvage V", "PWY-6618:t:guanine and guanosine salvage III"], "type": "Family"}, "IPR046406": {"description": "Inner membrane lipoprotein DcrB", "go_ids": [], "go_terms": [], "name": "DcrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046407": {"description": "Carboxylic acid reductase", "go_ids": ["GO:0016620", "GO:0005524", "GO:0006629", "GO:0031177", "GO:0050661"], "go_terms": ["GO:0016620:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor:F", "GO:0005524:ATP binding:F", "GO:0006629:lipid metabolic process:P", "GO:0031177:phosphopantetheine binding:F", "GO:0050661:NADP binding:F"], "name": "CAR", "pathway_ids": ["PWY-6309", "PWY-6322", "PWY-7769", "PWY-7035", "PWY-8419", "PWY-282", "PWY-7682", "PWY-7033", "PWY-5305", "PWY-6948", "PWY-7523", "PWY-5168", "PWY-7128", "PWY-7855", "PWY-321", "PWY-6863", "PWY-7654", "PWY-6681", "PWY-6713", "PWY-6832", "PWY-2724", "PWY-5875", "PWY-5885", "PWY-3162", "PWY-7423", "PWY-1121", "PWY-8151", "PWY-6926", "PWY-7703"], "pathways": ["PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7035:t:(9Z)-tricosene biosynthesis", "PWY-8419:t:L-canavanine degradation II", "PWY-282:t:cuticular wax biosynthesis", "PWY-7682:t:arabidopyrone biosynthesis", "PWY-7033:t:alkane biosynthesis II", "PWY-5305:t:bixin biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7523:t:L-arginine degradation XII", "PWY-5168:t:ferulate and sinapate biosynthesis", "PWY-7128:t:nicotine degradation III (VPP pathway)", "PWY-7855:t:ectoine degradation", "PWY-321:t:cutin biosynthesis", "PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-6681:t:neurosporaxanthin biosynthesis", "PWY-6713:t:L-rhamnose degradation II", "PWY-6832:t:2-aminoethylphosphonate degradation II", "PWY-2724:t:alkane oxidation", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5885:t:wax esters biosynthesis II", "PWY-3162:t:L-tryptophan degradation V (side chain pathway)", "PWY-7423:t:bombykol biosynthesis", "PWY-1121:t:suberin monomers biosynthesis", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-6926:t:pyrethrin I biosynthesis", "PWY-7703:t:2,4-xylenol degradation to protocatechuate"], "type": "Family"}, "IPR046408": {"description": "Anamorsin, C-terminal", "go_ids": [], "go_terms": [], "name": "CIAPIN1", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Domain"}, "IPR046409": {"description": "Programmed cell death protein 10, dimerisation domain superfamily", "go_ids": [], "go_terms": [], "name": "PDC10_dimerisation_sf", "pathway_ids": ["R-CEL-75153", "R-HSA-111465", "R-HSA-75153", "R-DDI-75153", "R-MMU-111465", "R-RNO-75153", "R-MMU-75153", "R-RNO-111465"], "pathways": ["R-CEL-75153:r:Apoptotic execution phase", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-75153:r:Apoptotic execution phase", "R-DDI-75153:r:Apoptotic execution phase", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-75153:r:Apoptotic execution phase", "R-MMU-75153:r:Apoptotic execution phase", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Homologous_superfamily"}, "IPR046426": {"description": "Daxx, histone-binding domain superfamily", "go_ids": ["GO:0042393"], "go_terms": ["GO:0042393:histone binding:F"], "name": "DAXX_histone-bd_sf", "pathway_ids": ["R-RNO-6804757", "R-MMU-3899300", "R-CFA-9670095", "R-HSA-6804757", "R-HSA-9670095", "R-CFA-6804757", "R-MMU-6804757", "R-HSA-9670613", "R-HSA-9670615", "R-HSA-9920951", "R-HSA-3899300", "R-HSA-9609690", "R-RNO-3899300", "R-MMU-9670095"], "pathways": ["R-RNO-6804757:r:Regulation of TP53 Degradation", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-CFA-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-CFA-6804757:r:Regulation of TP53 Degradation", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-HSA-9670613:r:Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations", "R-HSA-9670615:r:Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9609690:r:HCMV Early Events", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere"], "type": "Homologous_superfamily"}, "IPR046427": {"description": "Legumain prodomain superfamily", "go_ids": [], "go_terms": [], "name": "Legumain_prodom_sf", "pathway_ids": ["R-RNO-1679131", "R-MMU-2132295", "R-MMU-1679131", "R-HSA-1679131", "R-HSA-196791", "R-HSA-2132295", "R-RNO-196791", "R-RNO-2132295"], "pathways": ["R-RNO-1679131:r:Trafficking and processing of endosomal TLR", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-2132295:r:MHC class II antigen presentation"], "type": "Homologous_superfamily"}, "IPR046428": {"description": "mRNA-capping enzyme catalytic subunit, OB fold domain superfamily", "go_ids": [], "go_terms": [], "name": "MCEL_OB_dom_sf", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Homologous_superfamily"}, "IPR046429": {"description": "mRNA-capping enzyme catalytic subunit, nucleotidyltransferase domain superfamily", "go_ids": ["GO:0004484"], "go_terms": ["GO:0004484:mRNA guanylyltransferase activity:F"], "name": "MCEL_NTPase_sf", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Homologous_superfamily"}, "IPR046430": {"description": "mRNA-capping enzyme catalytic subunit, RNA triphosphatase domain superfamily", "go_ids": ["GO:0050355"], "go_terms": ["GO:0050355:inorganic triphosphate phosphatase activity:F"], "name": "MCEL_TPase_sf", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Homologous_superfamily"}, "IPR046431": {"description": "Fantastic Four domain", "go_ids": [], "go_terms": [], "name": "FAF_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046432": {"description": "TASOR", "go_ids": ["GO:0045814"], "go_terms": ["GO:0045814:negative regulation of gene expression, epigenetic:P"], "name": "TASOR", "pathway_ids": ["R-HSA-9843970"], "pathways": ["R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "type": "Family"}, "IPR046433": {"description": "Acetyl-CoA hydrolase/transferase", "go_ids": ["GO:0008775", "GO:0006083"], "go_terms": ["GO:0008775:acetate CoA-transferase activity:F", "GO:0006083:acetate metabolic process:P"], "name": "ActCoA_hydro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046437": {"description": "Serine/threonine-protein kinase, first cryptic polo-box domain superfamily", "go_ids": [], "go_terms": [], "name": "Ser_Thr-PK_POLO_box_1_sf", "pathway_ids": ["R-DRE-380320", "R-MMU-380259", "R-RNO-8854518", "R-HSA-380284", "R-MMU-380270", "R-XTR-380270", "R-XTR-380284", "R-XTR-8854518", "R-RNO-5620912", "R-HSA-380270", "R-HSA-8854518", "R-XTR-380259", "R-XTR-380320", "R-MMU-380284", "R-BTA-380259", "R-RNO-380259", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-MMU-2565942", "R-XTR-5620912", "R-MMU-380320", "R-BTA-8854518", "R-BTA-380270", "R-BTA-2565942", "R-RNO-2565942", "R-BTA-5620912", "R-RNO-380284", "R-XTR-2565942", "R-BTA-380320", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-BTA-380284", "R-RNO-380270"], "pathways": ["R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Homologous_superfamily"}, "IPR046439": {"description": "Zinc finger, RZ-type", "go_ids": [], "go_terms": [], "name": "ZF_RZ_dom", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7250", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7511", "PWY-7887", "PWY-6841", "R-DRE-983168", "R-HSA-983168", "R-HSA-9725370", "R-HSA-9635465", "R-MMU-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7511:t:protein ubiquitination", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR046448": {"description": "ECSIT, N-terminal", "go_ids": [], "go_terms": [], "name": "ECSIT_N", "pathway_ids": ["R-MMU-975871", "R-HSA-975871", "R-HSA-166058", "R-HSA-975138", "R-MMU-166058", "R-MMU-6799198", "R-RNO-166058", "R-HSA-6799198", "R-DME-6799198", "R-XTR-6799198", "R-BTA-975871", "R-RNO-6799198", "R-RNO-975871", "R-BTA-166058", "R-XTR-975138", "R-DRE-6799198", "R-MMU-975138", "R-RNO-975138", "R-BTA-6799198", "R-BTA-975138", "R-XTR-166058", "R-XTR-975871"], "pathways": ["R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-MMU-6799198:r:Complex I biogenesis", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-XTR-6799198:r:Complex I biogenesis", "R-BTA-975871:r:MyD88 cascade initiated on plasma membrane", "R-RNO-6799198:r:Complex I biogenesis", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-BTA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-XTR-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-DRE-6799198:r:Complex I biogenesis", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-BTA-6799198:r:Complex I biogenesis", "R-BTA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-XTR-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-XTR-975871:r:MyD88 cascade initiated on plasma membrane"], "type": "Domain"}, "IPR046449": {"description": "Protease Do-like, PDZ domain superfamily", "go_ids": [], "go_terms": [], "name": "DEGP_PDZ_sf", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Homologous_superfamily"}, "IPR046450": {"description": "PA domain superfamily", "go_ids": [], "go_terms": [], "name": "PA_dom_sf", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-MMU-8856828", "R-MMU-9013106", "R-HSA-5689896", "R-HSA-8856828", "R-HSA-5689880", "R-SSC-9013408", "R-MMU-9013408", "R-RNO-9013149", "R-RNO-5357905", "R-SSC-9013026", "R-MMU-9013404", "R-SSC-917977", "R-MMU-5689896", "R-DME-5689896", "R-SPO-9013106", "R-MMU-5689880", "R-SSC-9013407", "R-SCE-8980692", "R-SPO-9696273", "R-RNO-9013408", "R-RNO-9013406", "R-HSA-9013408", "R-RNO-9013404", "R-SCE-9696273", "R-RNO-917977", "R-SSC-432722", "R-RNO-432722", "R-SCE-8963693", "R-MMU-9013407", "R-RNO-8963693", "R-HSA-8963693", "R-RNO-9013407", "R-SSC-9013406", "R-RNO-9696273", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-917977", "R-MMU-9013406", "R-MMU-5357905", "R-SSC-9013149", "R-MMU-8963693", "R-HSA-9013026", "R-HSA-917977", "R-RNO-983168", "R-HSA-9013407", "R-SSC-9013148", "R-SSC-9696270", "R-HSA-9725554", "R-SSC-9013404", "R-MMU-8856825", "R-HSA-901032", "R-RNO-9696270", "R-MMU-8980692", "R-MMU-432722", "R-RNO-8980692", "R-HSA-9013106", "R-SSC-8980692", "R-SPO-9013406", "R-HSA-9013423", "R-HSA-5357905", "R-SCE-9013406", "R-HSA-9013148", "R-SSC-8856825", "R-RNO-9013106", "R-RNO-8856828", "R-HSA-432722", "R-CEL-8963693", "R-SPO-8963693", "R-RNO-8856825", "R-HSA-9696270", "R-SSC-9696273", "R-SSC-9013423", "R-HSA-983168", "R-SCE-9013106", "R-RNO-9013423", "R-SSC-8856828", "R-HSA-8856825", "R-MMU-9013026", "R-MMU-983168", "R-SSC-9013106", "R-HSA-9013406", "R-MMU-9696270", "R-MMU-9696273", "R-MMU-9013149", "R-DME-5689880", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SSC-9013408:r:RHOG GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-SSC-9013026:r:RHOB GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-SSC-917977:r:Transferrin endocytosis and recycling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-SPO-9013106:r:RHOC GTPase cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SSC-9013407:r:RHOH GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SPO-9696273:r:RND1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-SCE-9696273:r:RND1 GTPase cycle", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-SSC-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-8963693:r:Aspartate and asparagine metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-SSC-9013406:r:RHOQ GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-SSC-9013149:r:RAC1 GTPase cycle", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-SSC-9013148:r:CDC42 GTPase cycle", "R-SSC-9696270:r:RND2 GTPase cycle", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-SSC-9013404:r:RAC2 GTPase cycle", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-SSC-8980692:r:RHOA GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-SPO-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9696270:r:RND2 GTPase cycle", "R-SSC-9696273:r:RND1 GTPase cycle", "R-SSC-9013423:r:RAC3 GTPase cycle", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9013106:r:RHOC GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-9013106:r:RHOC GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Homologous_superfamily"}, "IPR046451": {"description": "Homogentisate 1,2-dioxygenase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HgmA_C", "pathway_ids": ["R-DME-8963684", "R-HSA-8963684", "R-CEL-8963684", "R-DDI-8963684", "R-MMU-8963684"], "pathways": ["R-DME-8963684:r:Tyrosine catabolism", "R-HSA-8963684:r:Tyrosine catabolism", "R-CEL-8963684:r:Tyrosine catabolism", "R-DDI-8963684:r:Tyrosine catabolism", "R-MMU-8963684:r:Tyrosine catabolism"], "type": "Domain"}, "IPR046452": {"description": "Homogentisate 1,2-dioxygenase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HgmA_N", "pathway_ids": ["R-DME-8963684", "R-HSA-8963684", "R-CEL-8963684", "R-DDI-8963684", "R-MMU-8963684"], "pathways": ["R-DME-8963684:r:Tyrosine catabolism", "R-HSA-8963684:r:Tyrosine catabolism", "R-CEL-8963684:r:Tyrosine catabolism", "R-DDI-8963684:r:Tyrosine catabolism", "R-MMU-8963684:r:Tyrosine catabolism"], "type": "Domain"}, "IPR046453": {"description": "Phage terminase large subunit GpA, ATPase domain", "go_ids": ["GO:0016887"], "go_terms": ["GO:0016887:ATP hydrolysis activity:F"], "name": "GpA_ATPase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046454": {"description": "Terminase large subunit GpA, endonuclease domain", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "GpA_endonuclease", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046455": {"description": "Sec7/BIG1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Sec7/BIG1-like_C", "pathway_ids": ["R-HSA-390471"], "pathways": ["R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis"], "type": "Domain"}, "IPR046456": {"description": "Phosphomannose isomerase type I, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PMI_typeI_C", "pathway_ids": ["PWY-5659", "PWY-3861", "PWY-6992", "PWY-7586", "PWY-3881", "PWY-7456", "R-MMU-446205", "R-HSA-4043916", "R-CEL-446205", "R-SCE-446205", "R-HSA-446205", "R-BTA-446205", "R-RNO-446205", "R-SPO-446205"], "pathways": ["PWY-5659:t:GDP-mannose biosynthesis", "PWY-3861:t:mannitol degradation II", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7586:t:beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation", "PWY-3881:t:mannitol biosynthesis", "PWY-7456:t:beta-(1,4)-mannan degradation", "R-MMU-446205:r:Synthesis of GDP-mannose", "R-HSA-4043916:r:Defective MPI causes MPI-CDG", "R-CEL-446205:r:Synthesis of GDP-mannose", "R-SCE-446205:r:Synthesis of GDP-mannose", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-BTA-446205:r:Synthesis of GDP-mannose", "R-RNO-446205:r:Synthesis of GDP-mannose", "R-SPO-446205:r:Synthesis of GDP-mannose"], "type": "Domain"}, "IPR046457": {"description": "Phosphomannose isomerase type I, catalytic domain", "go_ids": ["GO:0004476", "GO:0008270"], "go_terms": ["GO:0004476:mannose-6-phosphate isomerase activity:F", "GO:0008270:zinc ion binding:F"], "name": "PMI_typeI_cat", "pathway_ids": ["PWY-5659", "PWY-3861", "PWY-6992", "PWY-7586", "PWY-3881", "PWY-7456", "R-HSA-4043916", "R-HSA-446205", "R-RNO-446205", "R-SPO-446205", "R-DDI-446205", "R-MMU-446205", "R-BTA-446205", "R-CEL-446205", "R-SCE-446205"], "pathways": ["PWY-5659:t:GDP-mannose biosynthesis", "PWY-3861:t:mannitol degradation II", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7586:t:beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation", "PWY-3881:t:mannitol biosynthesis", "PWY-7456:t:beta-(1,4)-mannan degradation", "R-HSA-4043916:r:Defective MPI causes MPI-CDG", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-RNO-446205:r:Synthesis of GDP-mannose", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-DDI-446205:r:Synthesis of GDP-mannose", "R-MMU-446205:r:Synthesis of GDP-mannose", "R-BTA-446205:r:Synthesis of GDP-mannose", "R-CEL-446205:r:Synthesis of GDP-mannose", "R-SCE-446205:r:Synthesis of GDP-mannose"], "type": "Domain"}, "IPR046458": {"description": "Phosphomannose isomerase type I, helical insertion domain", "go_ids": [], "go_terms": [], "name": "PMI_typeI_hel", "pathway_ids": ["PWY-5659", "PWY-3861", "PWY-6992", "PWY-7586", "PWY-3881", "PWY-7456", "R-HSA-4043916", "R-HSA-446205", "R-RNO-446205", "R-SPO-446205", "R-DDI-446205", "R-MMU-446205", "R-BTA-446205", "R-CEL-446205", "R-SCE-446205"], "pathways": ["PWY-5659:t:GDP-mannose biosynthesis", "PWY-3861:t:mannitol degradation II", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7586:t:beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation", "PWY-3881:t:mannitol biosynthesis", "PWY-7456:t:beta-(1,4)-mannan degradation", "R-HSA-4043916:r:Defective MPI causes MPI-CDG", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-RNO-446205:r:Synthesis of GDP-mannose", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-DDI-446205:r:Synthesis of GDP-mannose", "R-MMU-446205:r:Synthesis of GDP-mannose", "R-BTA-446205:r:Synthesis of GDP-mannose", "R-CEL-446205:r:Synthesis of GDP-mannose", "R-SCE-446205:r:Synthesis of GDP-mannose"], "type": "Domain"}, "IPR046459": {"description": "Capsule biosynthesis GfcC-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Caps_syn_GfcC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046460": {"description": 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function DUF6548", "go_ids": [], "go_terms": [], "name": "DUF6548", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046679": {"description": "Protein of unknown function DUF6549", "go_ids": [], "go_terms": [], "name": "DUF6549", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046680": {"description": "Protein of unknown function DUF6550", "go_ids": [], "go_terms": [], "name": "DUF6550", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046681": {"description": "Protein of unknown function DUF6551", "go_ids": [], "go_terms": [], "name": "DUF6551", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046682": {"description": "Protein of unknown function DUF6552", "go_ids": [], "go_terms": [], "name": "DUF6552", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046683": {"description": "Protein of unknown function DUF6553", "go_ids": [], "go_terms": [], "name": "DUF6553", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046684": 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"Family"}, "IPR046690": {"description": "Protein of unknown function DUF6560", "go_ids": [], "go_terms": [], "name": "DUF6560", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046691": {"description": "Protein of unknown function DUF6561", "go_ids": [], "go_terms": [], "name": "DUF6561", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046692": {"description": "Domain of unknown function DUF6562", "go_ids": [], "go_terms": [], "name": "DUF6562", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046693": {"description": "Protein of unknown function DUF6563", "go_ids": [], "go_terms": [], "name": "DUF6563", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046694": {"description": "Domain of unknown function DUF6564", "go_ids": [], "go_terms": [], "name": "DUF6564", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046695": {"description": "Domain of unknown function DUF6565", "go_ids": [], "go_terms": [], "name": "DUF6565", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046696": {"description": "Domain of unknown function DUF6566", "go_ids": [], "go_terms": [], "name": "DUF6566", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046697": {"description": "Protein of unknown function DUF6567", "go_ids": [], "go_terms": [], "name": "DUF6567", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046698": {"description": "Pediocin PA-1 biosynthesis protein PedC-like", "go_ids": [], "go_terms": [], "name": "PedC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046699": {"description": "ARG and Rhodanese-Phosphatase-superfamily-associated domain", "go_ids": [], "go_terms": [], "name": "ARPP-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046700": {"description": "Domain of unknown function DUF6570", "go_ids": [], "go_terms": [], "name": "DUF6570", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046701": {"description": "Domain of unknown function DUF6571", "go_ids": [], "go_terms": [], "name": "DUF6571", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046702": {"description": "Protein of unknown function DUF6572", "go_ids": [], "go_terms": [], "name": "DUF6572", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046703": {"description": "Protein of unknown function DUF6776", "go_ids": [], "go_terms": [], "name": "DUF6776", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046704": {"description": "Domain of unknown function DUF6777", "go_ids": [], "go_terms": [], "name": "DUF6777", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046705": {"description": "Protein of unknown function DUF6778", "go_ids": [], "go_terms": [], "name": "DUF6778", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046706": {"description": "Domain of unknown function DUF6779", "go_ids": [], "go_terms": [], "name": "DUF6779", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046707": {"description": "Domain of unknown function DUF6780", "go_ids": [], "go_terms": [], "name": "DUF6780", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046708": {"description": "Protein of unknown function DUF6781", "go_ids": [], "go_terms": [], "name": "DUF6781", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046709": {"description": "Domain of unknown function DUF6782", "go_ids": [], "go_terms": [], "name": "DUF6782", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046710": {"description": "Protein of unknown function DUF6783", "go_ids": [], "go_terms": [], "name": "DUF6783", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046712": {"description": "Domain of unknown function DUF6785", "go_ids": [], "go_terms": [], "name": "DUF6785", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046713": {"description": "Protein of unknown function DUF6786", "go_ids": [], "go_terms": [], "name": "DUF6786", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046714": {"description": "Domain of unknown function DUF6787", "go_ids": [], "go_terms": [], "name": "DUF6787", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046715": {"description": "Protein of unknown function DUF6607", "go_ids": [], "go_terms": [], "name": "DUF6607", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046716": {"description": "Protein of unknown function DUF6608", "go_ids": [], "go_terms": [], "name": "DUF6608", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046717": {"description": "Protein of unknown function DUF6609", "go_ids": [], "go_terms": [], "name": "DUF6609", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046718": {"description": "Protein of unknown function DUF6610", "go_ids": [], "go_terms": [], "name": "DUF6610", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046719": {"description": "Protein of unknown function DUF6611", "go_ids": [], "go_terms": [], "name": "DUF6611", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046720": {"description": "Protein of unknown function DUF6612", "go_ids": [], "go_terms": [], "name": "DUF6612", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046722": {"description": "Protein of unknown function DUF6614", "go_ids": [], "go_terms": [], "name": "DUF6614", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046723": {"description": "Protein of unknown function DUF6615", "go_ids": [], "go_terms": [], "name": "DUF6615", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046724": {"description": "Protein of unknown function DUF6616", "go_ids": [], "go_terms": [], "name": "DUF6616", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046725": {"description": "Protein of unknown function DUF6617", "go_ids": [], "go_terms": [], "name": "DUF6617", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046726": {"description": "Protein of unknown function DUF6618", "go_ids": [], "go_terms": [], "name": "DUF6618", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046727": {"description": "Domain of unknown function DUF6619", "go_ids": [], "go_terms": [], "name": "DUF6619", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046728": {"description": "Protein of unknown function DUF6620", "go_ids": [], "go_terms": [], "name": "DUF6620", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046729": {"description": "Protein of unknown function DUF6621", "go_ids": [], "go_terms": [], "name": "DUF6621", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046730": {"description": "Protein of unknown function DUF6622", "go_ids": [], "go_terms": [], "name": "DUF6622", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046731": {"description": "Protein of unknown function DUF6623", "go_ids": [], "go_terms": [], "name": "DUF6623", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046732": {"description": "Protein of unknown function DUF6624", "go_ids": [], "go_terms": [], "name": "DUF6624", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046733": {"description": "Protein of unknown function DUF6625", "go_ids": [], "go_terms": [], "name": "DUF6625", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046734": {"description": "Protein of unknown function DUF6626", "go_ids": [], "go_terms": [], "name": "DUF6626", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046735": {"description": "Protein of unknown function DUF6627, PA2779-like", "go_ids": [], "go_terms": [], "name": "PA2779-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046736": {"description": "Protein of unknown function DUF6628", "go_ids": [], "go_terms": [], "name": "DUF6628", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046737": {"description": "Protein of unknown function DUF6629", "go_ids": [], "go_terms": [], "name": "DUF6629", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046738": {"description": "Domain of unknown function DUF6788", "go_ids": [], "go_terms": [], "name": "DUF6788", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046739": {"description": "Protein of unknown function DUF6789", "go_ids": [], "go_terms": [], "name": "DUF6789", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046740": {"description": "Protein of unknown function DUF6790", "go_ids": [], "go_terms": [], "name": "DUF6790", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046741": {"description": "Domain of unknown function DUF6791", "go_ids": [], "go_terms": [], "name": "DUF6791", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046742": {"description": "Domain of unknown function DUF6792", "go_ids": [], "go_terms": [], "name": "DUF6792", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046743": {"description": "Protein of unknown function DUF6793", "go_ids": [], "go_terms": [], "name": "DUF6793", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046744": {"description": "Domain of unknown function DUF6794", "go_ids": [], "go_terms": [], "name": "DUF6794", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046745": {"description": "Protein of unknown function DUF6675", "go_ids": [], "go_terms": [], "name": "DUF6675", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046746": {"description": "Bacterial Ig domain 15", "go_ids": [], "go_terms": [], "name": "Big_15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046747": {"description": "RNAse III-like, virus", "go_ids": [], "go_terms": [], "name": "Mycovirus_RNAse", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046748": {"description": "HipA-like kinase", "go_ids": [], "go_terms": [], "name": "HipA_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046749": {"description": "SHOCT-like domain", "go_ids": [], "go_terms": [], "name": "SHOCT_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046750": {"description": "RNA-directed RNA polymerase, 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"Domain"}, "IPR046754": {"description": "Torsin-1A-interacting protein 1/2, N-terminal", "go_ids": [], "go_terms": [], "name": "TOIP1/2_N", "pathway_ids": ["R-HSA-9013405", "R-RNO-9035034", "R-MMU-9035034", "R-HSA-9035034", "R-BTA-9035034"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-BTA-9035034:r:RHOF GTPase cycle"], "type": "Domain"}, "IPR046755": {"description": "V-type proton ATPase subunit S1, luminal domain", "go_ids": [], "go_terms": [], "name": "VAS1_LD", "pathway_ids": ["R-MMU-77387", "R-DME-917977", "R-BTA-983712", "R-HSA-77387", "R-DME-77387", "R-RNO-8980692", "R-MMU-8980692", "R-RNO-77387", "R-RNO-983712", "R-BTA-917977", "R-HSA-983712", "R-HSA-8980692", "R-DME-983712", "R-MMU-917977", "R-BTA-8980692", "R-HSA-917977", "R-MMU-983712", "R-BTA-77387", "R-RNO-917977"], "pathways": ["R-MMU-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-HSA-77387:r:Insulin receptor recycling", "R-DME-77387:r:Insulin receptor recycling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-77387:r:Insulin receptor recycling", "R-RNO-983712:r:Ion channel transport", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-BTA-8980692:r:RHOA GTPase cycle", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-BTA-77387:r:Insulin receptor recycling", "R-RNO-917977:r:Transferrin endocytosis and recycling"], "type": "Domain"}, "IPR046756": {"description": "V-type proton ATPase subunit S1/VOA1, transmembrane domain", "go_ids": [], "go_terms": [], "name": "VAS1/VOA1_TM", "pathway_ids": ["R-MMU-77387", "R-DME-917977", "R-BTA-983712", "R-HSA-77387", "R-DME-77387", "R-RNO-8980692", "R-MMU-8980692", "R-RNO-77387", "R-CEL-77387", "R-RNO-983712", "R-BTA-917977", "R-HSA-983712", "R-HSA-8980692", "R-CEL-983712", "R-DME-983712", "R-MMU-917977", "R-CEL-917977", "R-BTA-8980692", "R-HSA-917977", "R-MMU-983712", "R-BTA-77387", "R-RNO-917977"], "pathways": ["R-MMU-77387:r:Insulin receptor recycling", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-HSA-77387:r:Insulin receptor recycling", "R-DME-77387:r:Insulin receptor recycling", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-77387:r:Insulin receptor recycling", "R-CEL-77387:r:Insulin receptor recycling", "R-RNO-983712:r:Ion channel transport", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-HSA-8980692:r:RHOA GTPase cycle", "R-CEL-983712:r:Ion channel transport", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-BTA-8980692:r:RHOA GTPase cycle", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-BTA-77387:r:Insulin receptor recycling", "R-RNO-917977:r:Transferrin endocytosis and recycling"], "type": "Domain"}, "IPR046757": {"description": "Vps72/YL1, N-terminal", "go_ids": [], "go_terms": [], "name": "YL1_N", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR046758": {"description": "Sey1/RHD3-like, three-helix bundle domain", "go_ids": [], "go_terms": [], "name": "Sey1/RHD3-like_3HB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046760": {"description": "RNA-binding protein Tab2-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Tab2-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046761": {"description": "RNA-binding protein Tab2/Atab2, C-terminal", "go_ids": [], "go_terms": [], "name": "Tab2-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046762": {"description": "Putative adhesive domain (group 17)", "go_ids": [], "go_terms": [], "name": "pAdhesive_17", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046763": {"description": "Phage tail tube protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Phage_tube_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046764": {"description": "Phage tail tube protein, N-terminal", "go_ids": [], "go_terms": [], "name": "L_lac_phage_MSP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046765": {"description": "Antitoxin-like, ribbon-helix-helix", "go_ids": [], "go_terms": [], "name": "Antitox_RHH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046766": {"description": "Bacterial hydrolase", "go_ids": [], "go_terms": [], "name": "Bact_hydrolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046767": {"description": "Putative adhesive domain (group 8)", "go_ids": [], "go_terms": [], "name": "pAdhesive_8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046768": {"description": "Exodeoxyribonuclease X-like, C-terminal", "go_ids": [], "go_terms": [], "name": "ExoX-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046769": {"description": "DOCKER, Lobe A", "go_ids": [], "go_terms": [], "name": "DOCKER_Lobe_A", "pathway_ids": ["R-HSA-9013409", "R-HSA-6798695", "R-HSA-8875555", "R-MMU-8980692", "R-MMU-9013408", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-983231", "R-HSA-418885", "R-MMU-4420097", "R-HSA-8849471", "R-HSA-4420097", "R-HSA-9032759", "R-HSA-9013423", "R-HSA-9013148", "R-HSA-164944", "R-DRE-9013149", "R-HSA-9013408", "R-MMU-8849471", "R-HSA-9664422", "R-HSA-983231", "R-HSA-2029482", "R-MMU-2029482", "R-HSA-9013404", "R-DRE-983231", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-MMU-8875555", "R-HSA-8980692", "R-MMU-9032759", "R-MMU-6798695", "R-MMU-9013149", "R-MMU-418885"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-164944:r:Nef and signal transduction", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR046770": {"description": "DOCKER, Lobe B", "go_ids": [], "go_terms": [], "name": "DOCKER_Lobe_B", "pathway_ids": ["R-HSA-9013409", "R-HSA-6798695", "R-HSA-8875555", "R-MMU-8980692", "R-MMU-9013408", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-983231", "R-HSA-418885", "R-MMU-4420097", "R-HSA-8849471", "R-HSA-4420097", "R-HSA-9032759", "R-HSA-9013423", "R-HSA-9013148", "R-HSA-164944", "R-DRE-9013149", "R-HSA-9013408", "R-MMU-8849471", "R-HSA-9664422", "R-HSA-983231", "R-HSA-2029482", "R-MMU-2029482", "R-HSA-9013404", "R-DRE-983231", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-MMU-8875555", "R-HSA-8980692", "R-MMU-9032759", "R-MMU-6798695", "R-MMU-9013149", "R-MMU-418885"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-164944:r:Nef and signal transduction", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR046771": {"description": "Putative adhesive domain (group 11)", "go_ids": [], "go_terms": [], "name": "pAdhesive_11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046772": {"description": "Putative adhesive domain (group 6)", "go_ids": [], "go_terms": [], "name": "pAdhesive_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046773": {"description": "DOCKER, Lobe C", "go_ids": [], "go_terms": [], "name": "DOCKER_Lobe_C", "pathway_ids": ["R-HSA-9013409", "R-HSA-6798695", "R-HSA-8875555", "R-MMU-8980692", "R-SCE-6798695", "R-MMU-9013408", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-983231", "R-HSA-418885", "R-MMU-4420097", "R-HSA-8849471", "R-HSA-4420097", "R-HSA-9032759", "R-HSA-9013423", "R-SCE-9013149", "R-HSA-9013148", "R-HSA-164944", "R-DRE-9013149", "R-HSA-9013408", "R-MMU-8849471", "R-HSA-983231", "R-HSA-2029482", "R-MMU-2029482", "R-HSA-9013404", "R-DRE-983231", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-MMU-8875555", "R-HSA-8980692", "R-MMU-9013149", "R-MMU-9032759", "R-MMU-6798695", "R-HSA-9664422", "R-SCE-983231", "R-MMU-418885"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-MMU-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-164944:r:Nef and signal transduction", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR046774": {"description": "Putative adhesin domain (group 10)", "go_ids": [], "go_terms": [], "name": "pAdhesive_10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046775": {"description": "Cyclin-D-binding Myb-like transcription factor 1, N-terminal", "go_ids": [], "go_terms": [], "name": "DMTF1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046776": {"description": "Putative pectate lyase-like adhesive domain", "go_ids": [], "go_terms": [], "name": "Pectate_lyase_5", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR046777": {"description": "GvpD, basic region 2", "go_ids": [], "go_terms": [], "name": "GvpD_bR2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046778": {"description": "UPF0758, N-terminal", "go_ids": [], "go_terms": [], "name": "UPF0758_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046779": {"description": "LapA adhesin domain", "go_ids": [], "go_terms": [], "name": "LapA_adhesin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046780": {"description": "Atrophied bacterial Ig domain", "go_ids": [], "go_terms": [], "name": "aBig_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046781": {"description": "ORF5/VP5", "go_ids": [], "go_terms": [], "name": "ORF5/VP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046782": {"description": "HEWD domain", "go_ids": [], "go_terms": [], "name": "HEWD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046783": {"description": "Helix-turn-helix protein, archaea", "go_ids": [], "go_terms": [], "name": "HTH_63", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046784": {"description": "eIF4E-associated protein", "go_ids": [], "go_terms": [], "name": "Eap1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046785": {"description": "SrpA-like, SigLec-like domain", "go_ids": [], "go_terms": [], "name": "SrpA-like_SigLec-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046786": {"description": "Motility protein A, N-terminal", "go_ids": [], "go_terms": [], "name": "MotA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046787": {"description": "Putative DnaT-like domain", "go_ids": [], "go_terms": [], "name": "DnaT_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046788": {"description": "Putative O-methyltransferase", "go_ids": [], "go_terms": [], "name": "Methyltransf_35", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046789": {"description": "Recombinase-like", "go_ids": [], "go_terms": [], "name": "HTH_62", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046790": {"description": "KBTB, W-type LIR motif", "go_ids": [], "go_terms": [], "name": "KBTB_W-LIR", "pathway_ids": ["R-HSA-983168", "R-HSA-5658442", "R-HSA-8951664"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-8951664:r:Neddylation"], "type": "Conserved_site"}, "IPR046791": {"description": "Polycystin domain", "go_ids": [], "go_terms": [], "name": "Polycystin_dom", "pathway_ids": ["R-CEL-5620916", "R-HSA-5620916", "R-DRE-5620916", "R-MMU-5620916", "R-BTA-5620916"], "pathways": ["R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-BTA-5620916:r:VxPx cargo-targeting to cilium"], "type": "Domain"}, "IPR046792": {"description": "Peptidase C54, catalytic domain", "go_ids": ["GO:0008234", "GO:0019786"], "go_terms": ["GO:0008234:cysteine-type peptidase activity:F", "GO:0019786:protein-phosphatidylethanolamide deconjugating activity:F"], "name": "Peptidase_C54_cat", "pathway_ids": ["R-SCE-1632852", "R-CFA-1632852", "R-RNO-1632852", "R-DDI-1632852", "R-XTR-1632852", "R-SSC-1632852", "R-DRE-1632852", "R-CEL-1632852", "R-HSA-1632852", "R-MMU-1632852", "R-SPO-1632852", "R-BTA-1632852"], "pathways": ["R-SCE-1632852:r:Macroautophagy", "R-CFA-1632852:r:Macroautophagy", "R-RNO-1632852:r:Macroautophagy", "R-DDI-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-SSC-1632852:r:Macroautophagy", "R-DRE-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-BTA-1632852:r:Macroautophagy"], "type": "Domain"}, "IPR046793": {"description": "Cysteine protease ATG4, F-type LIR motif", "go_ids": [], "go_terms": [], "name": "ATG4_LIR", "pathway_ids": ["R-HSA-1632852", "R-RNO-1632852", "R-MMU-1632852", "R-BTA-1632852", "R-DRE-1632852"], "pathways": ["R-HSA-1632852:r:Macroautophagy", "R-RNO-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-BTA-1632852:r:Macroautophagy", "R-DRE-1632852:r:Macroautophagy"], "type": "Conserved_site"}, "IPR046794": {"description": "Anaphase-promoting complex subunit 1, middle domain", "go_ids": [], "go_terms": [], "name": "Apc1_MidN", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-HSA-2467813", "R-MMU-2467813", "R-MMU-174154", "R-MMU-179409", "R-MMU-69017", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-DDI-176409", "R-DDI-2559582", "R-DDI-2467813", "R-DDI-176412", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-68867", "R-MMU-176409", "R-DDI-174084", "R-HSA-176409", "R-HSA-9687136", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-MMU-141430", "R-DDI-174184", "R-HSA-69017", "R-DDI-141430", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-DDI-174178", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Domain"}, "IPR046795": {"description": "Transmembrane protein 127, transmembrane region", "go_ids": [], "go_terms": [], "name": "TMEM127_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046796": {"description": "Putative plant retrotransposon-related domain", "go_ids": [], "go_terms": [], "name": "Transposase_32_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046797": {"description": "PD-(D/E)XK nuclease-like", "go_ids": [], "go_terms": [], "name": "PDDEXK_12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046798": {"description": "Tet-like 2OG-Fe(II) oxygenase", "go_ids": [], "go_terms": [], "name": "2OG-FeII_Oxy_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046799": {"description": "ROXA-like, winged helix", "go_ids": [], "go_terms": [], "name": "ROXA-like_wH", "pathway_ids": ["R-HSA-3214842", "R-RNO-9629569", "R-RNO-3214842", "R-MMU-9629569", "R-MMU-3214842", "R-HSA-9629569"], "pathways": ["R-HSA-3214842:r:HDMs demethylate histones", "R-RNO-9629569:r:Protein hydroxylation", "R-RNO-3214842:r:HDMs demethylate histones", "R-MMU-9629569:r:Protein hydroxylation", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Domain"}, "IPR046800": {"description": "Plexin, cytoplasmic RhoGTPase-binding domain", "go_ids": ["GO:0017154"], "go_terms": ["GO:0017154:semaphorin receptor activity:F"], "name": "Plexin_RBD", "pathway_ids": ["R-HSA-9013405", "R-HSA-416550", "R-HSA-399956", "R-HSA-416572", "R-DRE-399954", "R-CEL-416700", "R-CEL-416482", "R-MMU-416572", "R-RNO-399954", "R-HSA-9615017", "R-HSA-416700", "R-MMU-399954", "R-HSA-399955", "R-HSA-9696273", "R-RNO-399956", "R-HSA-9013508", "R-MMU-416700", "R-RNO-416700", "R-HSA-9696270", "R-MMU-399955", "R-HSA-416482", "R-CEL-416572", "R-DME-416572", "R-RNO-399955", "R-HSA-399954", "R-DRE-399956", "R-MMU-416482", "R-DME-416482", "R-DME-416700", "R-MMU-9696273", "R-MMU-9696270", "R-MMU-399956", "R-MMU-416550"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-399954:r:Sema3A PAK dependent Axon repulsion", "R-CEL-416700:r:Other semaphorin interactions", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-416700:r:Other semaphorin interactions", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-MMU-416700:r:Other semaphorin interactions", "R-RNO-416700:r:Other semaphorin interactions", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DME-416700:r:Other semaphorin interactions", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration"], "type": "Domain"}, "IPR046801": {"description": "Glucose-6-phosphate dehydrogenase assembly protein OpcA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "OpcA_G6PD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046802": {"description": "Glucose-6-phosphate dehydrogenase assembly protein OpcA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "OpcA_G6PD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046803": {"description": "DNA-dependent protein kinase catalytic subunit, CC1/2", "go_ids": [], "go_terms": [], "name": "DNAPKcs_CC1-2", "pathway_ids": ["R-HSA-8866654", "R-HSA-3270619", "R-MMU-8866654", "R-HSA-5693571", "R-GGA-353423", "R-DDI-5693571", "R-GGA-351433", "R-HSA-1834949", "R-MMU-5693571"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Domain"}, "IPR046804": {"description": "DNA-PKcs, N-terminal", "go_ids": [], "go_terms": [], "name": "DNA-PKcs_N", "pathway_ids": ["R-HSA-8866654", "R-HSA-3270619", "R-MMU-8866654", "R-HSA-5693571", "R-GGA-353423", "R-DDI-5693571", "R-GGA-351433", "R-HSA-1834949", "R-MMU-5693571"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-353423:r:Non-homologous end joining (NHEJ)", "R-DDI-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-GGA-351433:r:ATM mediated phosphorylation of repair proteins", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Domain"}, "IPR046805": {"description": "Tra1, HEAT repeat ring region", "go_ids": [], "go_terms": [], "name": "Tra1_ring", "pathway_ids": ["R-DRE-5689880", "R-HSA-201722", "R-HSA-5689880", "R-DRE-201722", "R-HSA-3214847", "R-DME-5689880", "R-CEL-201722", "R-DDI-5689880", "R-DME-201722"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex"], "type": "Repeat"}, "IPR046806": {"description": "MrpA C-terminal/MbhE", "go_ids": [], "go_terms": [], "name": "MrpA_C/MbhE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046807": {"description": "Tra1, HEAT repeat central region", "go_ids": [], "go_terms": [], "name": "Tra1_central", "pathway_ids": ["R-DRE-5689880", "R-HSA-201722", "R-HSA-5689880", "R-DRE-201722", "R-HSA-3214847", "R-DME-5689880", "R-CEL-201722", "R-DDI-5689880", "R-DME-201722"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DRE-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex"], "type": "Repeat"}, "IPR046808": {"description": "Double strand break localizing Dbl7", "go_ids": ["GO:0035861"], "go_terms": ["GO:0035861:site of double-strand break:C"], "name": "Dbl7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046809": {"description": "Lipoprotein YfjS/YafY domain", "go_ids": [], "go_terms": [], "name": "YfjS_YafY_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046810": {"description": "Ezrin/radixin/moesin, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "ERM_helical", "pathway_ids": ["R-MMU-437239", "R-RNO-437239", "R-DME-437239", "R-HSA-9662361", "R-DME-5627123", "R-HSA-437239", "R-BTA-373752", "R-HSA-8950505", "R-HSA-2029482", "R-HSA-373752", "R-MMU-2029482", "R-DME-2029482", "R-HSA-5627123", "R-HSA-9662360", "R-MMU-5627123", "R-RNO-373752", "R-MMU-373752", "R-HSA-9725370", "R-DME-373752"], "pathways": ["R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-373752:r:Netrin-1 signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-373752:r:Netrin-1 signaling", "R-MMU-373752:r:Netrin-1 signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-373752:r:Netrin-1 signaling"], "type": "Domain"}, "IPR046811": {"description": "RNA-directed RNA polymerase, thumb subdomain, flavivirus", "go_ids": [], "go_terms": [], "name": "Flavi_NS5_thumb", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7375", "PWY-7184", "PWY-7210", "PWY-7379", "R-HSA-9918485", "R-HSA-9918487", "R-HSA-9920951", "R-HSA-9918481", "R-HSA-9920588", "R-HSA-9918476", "R-HSA-9918432"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7375:t:mRNA capping I", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7379:t:mRNA capping II", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR046812": {"description": "RNA-directed RNA polymerase, palm domain superfamily, Birnavirus", "go_ids": [], "go_terms": [], "name": "Birnavirus_RdRp_palm_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR046813": {"description": "RNA-directed RNA polymerase, thumb domain superfamily, Birnavirus", "go_ids": [], "go_terms": [], "name": "Birnavirus_RdRp_thumb_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR046814": {"description": "RNA-directed RNA polymerase, C-terminal domain superfamily, Avibirnavirus", "go_ids": [], "go_terms": [], "name": "Avibirnavurs_RdRp_C_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR046815": {"description": "P2X purinoreceptor 7, intracellular domain", "go_ids": [], "go_terms": [], "name": "P2RX7_C", "pathway_ids": ["R-HSA-139853", "R-MMU-139853", "R-RNO-139853", "R-MMU-418346", "R-HSA-9660826", "R-HSA-9856532", "R-RNO-844456", "R-MMU-844456", "R-HSA-418346", "R-HSA-844456", "R-RNO-418346"], "pathways": ["R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-418346:r:Platelet homeostasis", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-HSA-418346:r:Platelet homeostasis", "R-HSA-844456:r:The NLRP3 inflammasome", "R-RNO-418346:r:Platelet homeostasis"], "type": "Domain"}, "IPR046816": {"description": "MmeI-like, DNA-methyltransferase domain", "go_ids": [], "go_terms": [], "name": "MmeI_Mtase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046817": {"description": "MmeI-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MmeI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046818": {"description": "MmeI-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MmeI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046819": {"description": "MmeI-like, helicase spacer domain", "go_ids": [], "go_terms": [], "name": "MmeI_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046820": {"description": "MmeI-like, target recognition domain", "go_ids": [], "go_terms": [], "name": "MmeI_TRD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046821": {"description": "PD-(D/E)XK nuclease domain", "go_ids": [], "go_terms": [], "name": "PDDEXK_11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046822": {"description": "BLOC-2 complex member HPS6, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HPS6_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046823": {"description": "BLOC-2 complex member HPS6, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HPS6_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046824": {"description": "Mitochondrial splicing suppressor 51-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Mss51-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046825": {"description": "Prephenate dehydrogenase, dimerization domain", "go_ids": [], "go_terms": [], "name": "PDH_C", "pathway_ids": ["PWY-7303"], "pathways": ["PWY-7303:t:4-hydroxy-3-prenylbenzoate biosynthesis"], "type": "Domain"}, "IPR046826": {"description": "Prephenate dehydrogenase, nucleotide-binding domain", "go_ids": ["GO:0070403"], "go_terms": ["GO:0070403:NAD+ binding:F"], "name": "PDH_N", "pathway_ids": ["PWY-7303"], "pathways": ["PWY-7303:t:4-hydroxy-3-prenylbenzoate biosynthesis"], "type": "Domain"}, "IPR046828": {"description": "Replication initiator protein", "go_ids": [], "go_terms": [], "name": "RepSA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046829": {"description": "Calmodulin binding protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Calmod_bind_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046830": {"description": "Calmodulin binding protein, central domain", "go_ids": [], "go_terms": [], "name": "Calmod_bind_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046831": {"description": "Calmodulin binding protein-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Calmodulin_bind_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046832": {"description": "DNA helicase E1, DNA-binding domain, papillomavirus", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "PPV_E1_DBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046833": {"description": "ATPase of the ABC class, N-terminal", "go_ids": [], "go_terms": [], "name": "ABC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046834": {"description": "ATPase of the ABC class, C-terminal", "go_ids": [], "go_terms": [], "name": "ABC_ATPase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046835": {"description": "Retrotransposon hot spot protein, N-terminal", "go_ids": [], "go_terms": [], "name": "RHS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046836": {"description": "Retrotransposon hot spot protein,C-terminal", "go_ids": [], "go_terms": [], "name": "RHS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046837": {"description": "Laa1/Sip1/HEATR5-like, HEAT repeat region", "go_ids": [], "go_terms": [], "name": "Laa1/Sip1/HEATR5-like_HEAT", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR046838": {"description": "BREX system Lon protease-like BrxL, N-terminal", "go_ids": [], "go_terms": [], "name": "BrxL_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046839": {"description": "ABC toxin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ABC_toxin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046840": {"description": "Sporulation stage IV protein A, C-terminal", "go_ids": [], "go_terms": [], "name": "SpoIVA_C", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR046841": {"description": "Stage IV sporulation protein A, middle domain", "go_ids": [], "go_terms": [], "name": "SpoIVA_middle", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR046842": {"description": "Stage IV sporulation protein A, ATPase domain", "go_ids": [], "go_terms": [], "name": "SpoIVA_ATPase", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR046843": {"description": "LonB, AAA+ ATPase LID domain, archaeal-type", "go_ids": [], "go_terms": [], "name": "LonB_AAA-LID", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR046844": {"description": "Lon-like, helical domain", "go_ids": [], "go_terms": [], "name": "Lon-like_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046845": {"description": "Meiosis-specific protein ASY3-like, coiled-coil", "go_ids": [], "go_terms": [], "name": "ASY3-like_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046846": {"description": "PKAT, KLD domain", "go_ids": [], "go_terms": [], "name": "PKAT_KLD", "pathway_ids": ["R-RNO-8857538", "R-HSA-9824585", "R-HSA-8857538", "R-MMU-8857538"], "pathways": ["R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Domain"}, "IPR046847": {"description": "Antitoxin Xre-like, helix-turn-helix domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Xre-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046848": {"description": "E motif", "go_ids": [], "go_terms": [], "name": "E_motif", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR046849": {"description": "E2 motif", "go_ids": [], "go_terms": [], "name": "E2_motif", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR046850": {"description": "Nuclear speckle splicing regulatory protein 1, RS-like domain", "go_ids": [], "go_terms": [], "name": "NRP1_C", "pathway_ids": ["R-HSA-72163", "R-RNO-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR046851": {"description": "Neurobeachin, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "NBCH_WD40", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-HSA-9609736", "R-HSA-112314", "R-DRE-6798695", "R-HSA-163615", "R-HSA-2122947"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-163615:r:PKA activation", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Domain"}, "IPR046852": {"description": "Neurobeachin, alpha-solenoid region", "go_ids": [], "go_terms": [], "name": "Neurobeachin_a-sol", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-HSA-9609736", "R-HSA-112314", "R-DRE-6798695", "R-HSA-163615", "R-HSA-2122947"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-163615:r:PKA activation", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription"], "type": "Domain"}, "IPR046853": {"description": "PilZN3 domain", "go_ids": [], "go_terms": [], "name": "PilZN3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046854": {"description": "Isocitrate dehydrogenase kinase/phosphatase (AceK), regulatory domain", "go_ids": [], "go_terms": [], "name": "AceK_regulatory", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Domain"}, "IPR046855": {"description": "Isocitrate dehydrogenase kinase/phosphatase (AceK), kinase domain", "go_ids": ["GO:0005524", "GO:0008772"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0008772:[isocitrate dehydrogenase (NADP+)] kinase activity:F"], "name": "AceK_kinase", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Domain"}, "IPR046856": {"description": "Gem-associated protein 6, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gemin6_C", "pathway_ids": ["R-BTA-191859", "R-MMU-191859", "R-HSA-9754678", "R-HSA-191859"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-MMU-191859:r:snRNP Assembly", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-191859:r:snRNP Assembly"], "type": "Domain"}, "IPR046857": {"description": "Gem-associated protein 6, Sm-like domain", "go_ids": [], "go_terms": [], "name": "Gemin6_Sm-like_dom", "pathway_ids": ["R-BTA-191859", "R-MMU-191859", "R-HSA-9754678", "R-HSA-191859"], "pathways": ["R-BTA-191859:r:snRNP Assembly", "R-MMU-191859:r:snRNP Assembly", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-191859:r:snRNP Assembly"], "type": "Domain"}, "IPR046858": {"description": "ChrB, N-terminal", "go_ids": [], "go_terms": [], "name": "ChrB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046859": {"description": "Ral GTPase-activating protein subunit alpha/beta, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RGPA/RALGAPB_N", "pathway_ids": ["R-MMU-9013407", "R-HSA-1445148", "R-HSA-9013407", "R-DME-9013407", "R-RNO-9013407"], "pathways": ["R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DME-9013407:r:RHOH GTPase cycle", "R-RNO-9013407:r:RHOH GTPase cycle"], "type": "Domain"}, "IPR046860": {"description": "SnoaL-like domain 5", "go_ids": [], "go_terms": [], "name": "SnoaL_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046861": {"description": "Kinase suppressor RAS 1, N-terminal helical hairpin", "go_ids": [], "go_terms": [], "name": "SAM_KSR1_N", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-6802952", "R-MMU-5673000", "R-HSA-5673000", "R-HSA-9649948", "R-HSA-6802946", "R-HSA-6802955", "R-MMU-5675221", "R-HSA-9656223", "R-HSA-5675221"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-5673000:r:RAF activation", "R-HSA-5673000:r:RAF activation", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR046862": {"description": "Rhomboid-like protein", "go_ids": [], "go_terms": [], "name": "Rhomboid_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046863": {"description": "Copper-binding protein MbnP-like domain", "go_ids": [], "go_terms": [], "name": "MbnP-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046864": {"description": "Toxin VasX, N-terminal region", "go_ids": [], "go_terms": [], "name": "VasX_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046865": {"description": "Flagellar Assembly Protein A, beta solenoid domain", "go_ids": [], "go_terms": [], "name": "FapA_b_solenoid", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR046866": {"description": "Flagellar Assembly Protein A , N-terminal region", "go_ids": [], "go_terms": [], "name": "FapA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046867": {"description": "Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain", "go_ids": [], "go_terms": [], "name": "AldOxase/xan_DH_MoCoBD2", "pathway_ids": ["R-MMU-9748787", "R-RNO-8851680", "R-HSA-8851680", "R-HSA-964975", "R-DDI-9748787", "R-RNO-74259", "R-GGA-421178", "R-DME-964975", "R-MMU-8851680", "R-HSA-9748787", "R-HSA-74259", "R-RNO-964975", "R-DME-74259", "R-MMU-964975", "R-CEL-964975", "R-DME-9748787", "R-MMU-74259", "R-DDI-964975", "R-RNO-9748787", "R-DDI-74259"], "pathways": ["R-MMU-9748787:r:Azathioprine ADME", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DDI-9748787:r:Azathioprine ADME", "R-RNO-74259:r:Purine catabolism", "R-GGA-421178:r:Urate synthesis", "R-DME-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-9748787:r:Azathioprine ADME", "R-HSA-74259:r:Purine catabolism", "R-RNO-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-74259:r:Purine catabolism", "R-MMU-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-CEL-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-DME-9748787:r:Azathioprine ADME", "R-MMU-74259:r:Purine catabolism", "R-DDI-964975:r:Vitamin B6 activation to pyridoxal phosphate", "R-RNO-9748787:r:Azathioprine ADME", "R-DDI-74259:r:Purine catabolism"], "type": "Domain"}, "IPR046868": {"description": "SLM1/RGC1-like, BAR-like domain", "go_ids": [], "go_terms": [], "name": "BAR_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046869": {"description": "SLM1/RGC1-like, PH domain", "go_ids": [], "go_terms": [], "name": "SLM1/RGC1-like_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046870": {"description": "ABC-three component systems, C-terminal domain 3", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046871": {"description": "RBE_0009-like", "go_ids": [], "go_terms": [], "name": "RBE_0009-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046872": {"description": "MAP3K, deoxyribohydrolase domain", "go_ids": [], "go_terms": [], "name": "DRHyd-ASK", "pathway_ids": ["R-HSA-2559580", "R-CEL-2559580", "R-MMU-2559580"], "pathways": ["R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-2559580:r:Oxidative Stress Induced Senescence"], "type": "Domain"}, "IPR046873": {"description": "MAP3K, HisK-N-like globin domain", "go_ids": [], "go_terms": [], "name": "HisK-N-like", "pathway_ids": ["R-HSA-2559580", "R-CEL-2559580", "R-MMU-2559580"], "pathways": ["R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-2559580:r:Oxidative Stress Induced Senescence"], "type": "Domain"}, "IPR046875": {"description": "Predicted novel nucleotide synthetase", "go_ids": [], "go_terms": [], "name": "Pred_NTSase1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046876": {"description": "Prokaryotic STING domain", "go_ids": [], "go_terms": [], "name": "Prok_STING", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046877": {"description": "Nucleotidyltransferase-Associated Rossmannoid Fold", "go_ids": [], "go_terms": [], "name": "NARF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046878": {"description": "Bacterial Ig-like domain 14", "go_ids": [], "go_terms": [], "name": "Big_14", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046879": {"description": "KANL3/Tex30, alpha/beta hydrolase-like domain", "go_ids": [], "go_terms": [], "name": "KANL3/Tex30_Abhydrolase", "pathway_ids": ["R-MMU-3214847", "R-MMU-9772755", "R-HSA-3214847", "R-HSA-9772755", "R-RNO-3214847", "R-DRE-3214847", "R-RNO-9772755"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-3214847:r:HATs acetylate histones", "R-DRE-3214847:r:HATs acetylate histones", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Domain"}, "IPR046880": {"description": "Tetratricopeptide Repeats-Sensor", "go_ids": [], "go_terms": [], "name": "TPR-S", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR046881": {"description": "Divergent DnaB-like ATPase", "go_ids": [], "go_terms": [], "name": "divDNAB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046882": {"description": "Small protein found in certain Dnd DNA modification systems", "go_ids": [], "go_terms": [], "name": "Sp-DndD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046883": {"description": "Type VI secretion system, FHA domain-containing protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "T6SS_FHA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046884": {"description": "tRNA-specific 2-thiouridylase MnmA-like, central domain", "go_ids": [], "go_terms": [], "name": "MnmA-like_central", "pathway_ids": ["PWY-7892", "PWY-7887", "R-HSA-6787450"], "pathways": ["PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR046885": {"description": "tRNA-specific 2-thiouridylase MnmA-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MnmA-like_C", "pathway_ids": ["PWY-7892", "PWY-7887", "R-HSA-6787450"], "pathways": ["PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR046886": {"description": "Ribosomal RNA small subunit methyltransferase E, methyltransferase domain", "go_ids": [], "go_terms": [], "name": "RsmE_MTase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046887": {"description": "Ribosomal RNA small subunit methyltransferase E, PUA-like domain", "go_ids": [], "go_terms": [], "name": "RsmE_PUA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046888": {"description": "Prokaryotic YEATS domain", "go_ids": [], "go_terms": [], "name": "pYEATS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046889": {"description": "Small protein from certain CxC ATPase-based DNA modification systems", "go_ids": [], "go_terms": [], "name": "Sp-CxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046890": {"description": "YEATS-Like-Associating Three TM", "go_ids": [], "go_terms": [], "name": "YLATT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046891": {"description": "Prokaryotic E2 domain", "go_ids": [], "go_terms": [], "name": "E2-ntca", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046892": {"description": "Cysteine-rich domain, C-terminal to E2 domain", "go_ids": [], "go_terms": [], "name": "E2-Crich", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046893": {"description": "MutS2 and Smr-associated SH3 domain", "go_ids": [], "go_terms": [], "name": "MSSS", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR046894": {"description": "Methylase-associated X1", "go_ids": [], "go_terms": [], "name": "MTaX1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046895": {"description": "ABC-three component system, Middle Component 8", "go_ids": [], "go_terms": [], "name": "ABC-3C_MC8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046896": {"description": "LYR motif-containing protein Cup1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Cup1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046897": {"description": "ABC-three component system, Middle Component 6", "go_ids": [], "go_terms": [], "name": "ABC-3C_MC6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046898": {"description": "ATPase RavA, LARA domain", "go_ids": [], "go_terms": [], "name": "RavA_LARA_dom", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR046899": {"description": "KTSC and Metallopeptidase-like, N-terminal fusion domain", "go_ids": [], "go_terms": [], "name": "KMPT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046900": {"description": "ABC-three component system, Middle Component 7", "go_ids": [], "go_terms": [], "name": "ABC-3C_MC7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046901": {"description": "ABC-three component system, Middle Component 5", "go_ids": [], "go_terms": [], "name": "ABC-3C_MC5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046902": {"description": "ABC-three component system, Middle Component 4", "go_ids": [], "go_terms": [], "name": "ABC-3C_MC4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046903": {"description": "Mab-21-like, nucleotidyltransferase domain", "go_ids": [], "go_terms": [], "name": "Mab-21-like_nuc_Trfase", "pathway_ids": ["R-HSA-9920588", "R-HSA-1834941"], "pathways": ["R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-1834941:r:STING mediated induction of host immune responses"], "type": "Domain"}, "IPR046904": {"description": "ABC-three component system, Middle Component 2", "go_ids": [], "go_terms": [], "name": "ABC-3C_MC2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046905": {"description": "ABC-three component system, Middle Component 1", "go_ids": [], "go_terms": [], "name": "ABC-3C_MC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046906": {"description": "Mab-21-like, HhH/H2TH-like domain", "go_ids": [], "go_terms": [], "name": "Mab-21_HhH/H2TH-like", "pathway_ids": ["R-HSA-9937383", "R-RNO-9937383", "R-MMU-9937383", "R-DRE-9937383", "R-HSA-9920588", "R-HSA-1834941"], "pathways": ["R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-1834941:r:STING mediated induction of host immune responses"], "type": "Domain"}, "IPR046907": {"description": "SH3 fold domain associated with phage DNA polymerases", "go_ids": [], "go_terms": [], "name": "SH3DP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046908": {"description": "Divergent Family B DNA polymerase", "go_ids": [], "go_terms": [], "name": "divDNApol", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046909": {"description": "Cyclic-phosphate processing, Receiver domain", "go_ids": [], "go_terms": [], "name": "cREC_REC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046910": {"description": "E2-E1 middle domain", "go_ids": [], "go_terms": [], "name": "E2-E1mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046911": {"description": "ABC-three component systems, C-terminal domain 9", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD9", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046912": {"description": "ABC-three component systems, C-terminal domain 8", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046913": {"description": "ABC-three component systems, C-terminal domain 7", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046914": {"description": "ABC-three component systems, C-terminal domain 6", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046915": {"description": "ABC-three component systems, C-terminal domain 5", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046916": {"description": "ABC-three component systems, C-terminal domain 4", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046917": {"description": "ABC-three component systems, C-terminal domain 12", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046918": {"description": "ABC-three component systems, C-terminal domain 2", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046919": {"description": "ABC-three component systems, C-terminal domain 10", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046920": {"description": "ABC-three component systems, C-terminal domain 1", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046921": {"description": "ABC-three component systems, C-terminal domain 11", "go_ids": [], "go_terms": [], "name": "ABC-3C_CTD11", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046922": {"description": "CASPASE and TPR Repeat-Associated, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CATRA-N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046923": {"description": "CASPASE and TPR Repeat-Associated, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CATRA-C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046924": {"description": "CATRA-Associated Small Protein", "go_ids": [], "go_terms": [], "name": "CATASP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046925": {"description": "WD-like domain, fungi", "go_ids": [], "go_terms": [], "name": "WD-like_fungi", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046926": {"description": "GREB1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GREB1_N", "pathway_ids": ["R-HSA-9018519", "R-MMU-9018519"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR046927": {"description": "GREB1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GREB1-like_C", "pathway_ids": ["R-HSA-9018519", "R-MMU-9018519"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR046928": {"description": "Ribosome maturation protein SDO1/SBDS, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SDO1/SBDS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR046929": {"description": "Transposon related HTH domain protein", "go_ids": [], "go_terms": [], "name": "HTH_Tnp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046930": {"description": "Bacterial helix-turn-helix", "go_ids": [], "go_terms": [], "name": "HTH_60", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046931": {"description": "DNA polymerase theta-like, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "HTH_61", "pathway_ids": ["R-MMU-5685939", "R-HSA-5685939"], "pathways": ["R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)"], "type": "Domain"}, "IPR046932": {"description": "ATPase RavA, LARA domain superfamily", "go_ids": [], "go_terms": [], "name": "RavA_LARA_sf", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Homologous_superfamily"}, "IPR046933": {"description": "Kinase suppressor RAS 1, N-terminal helical hairpin superfamily", "go_ids": [], "go_terms": [], "name": "SAM_KSR1_N_sf", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-6802952", "R-MMU-5673000", "R-HSA-5673000", "R-HSA-9649948", "R-HSA-6802946", "R-HSA-6802955", "R-MMU-5675221", "R-HSA-9656223", "R-HSA-5675221"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-5673000:r:RAF activation", "R-HSA-5673000:r:RAF activation", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Homologous_superfamily"}, "IPR046934": {"description": "PP2CA INTERACTING RING FINGER PROTEIN 2-like", "go_ids": [], "go_terms": [], "name": "PIR2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046935": {"description": "DNA helicase E1, DNA-binding domain superfamily, papillomavirus", "go_ids": [], "go_terms": [], "name": "PPV_E1_DBD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR046936": {"description": "Copper acquisition factor BIM1-like", "go_ids": [], "go_terms": [], "name": "BIM1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046937": {"description": "Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain", "go_ids": [], "go_terms": [], "name": "CAB1-4_N_A-dom", "pathway_ids": ["R-BTA-5576893", "R-RNO-5576893", "R-MMU-422356", "R-RNO-112308", "R-MMU-5576892", "R-HSA-400042", "R-HSA-9856532", "R-BTA-112308", "R-HSA-5576892", "R-HSA-419037", "R-BTA-5576892", "R-HSA-5576893", "R-RNO-422356", "R-HSA-9662360", "R-MMU-5576893", "R-BTA-422356", "R-HSA-422356", "R-HSA-112308", "R-MMU-112308", "R-RNO-5576892"], "pathways": ["R-BTA-5576893:r:Phase 2 - plateau phase", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-MMU-422356:r:Regulation of insulin secretion", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-BTA-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-419037:r:NCAM1 interactions", "R-BTA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-RNO-422356:r:Regulation of insulin secretion", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-BTA-422356:r:Regulation of insulin secretion", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-RNO-5576892:r:Phase 0 - rapid depolarisation"], "type": "Domain"}, "IPR046938": {"description": "DNA clamp superfamily", "go_ids": [], "go_terms": [], "name": "DNA_clamp_sf", "pathway_ids": ["R-BTA-174411", "R-DME-110314", "R-RNO-174437", "R-HSA-174414", "R-SPO-5656121", "R-SPO-5656169", "R-RNO-5655862", "R-MMU-6804756", "R-BTA-6804114", "R-CEL-69166", "R-RNO-6804114", "R-RNO-110314", "R-RNO-8866654", "R-DDI-6782210", "R-MMU-5685938", "R-RNO-69183", "R-MMU-110314", "R-MMU-69473", "R-CEL-110314", "R-DRE-69183", "R-MMU-174414", "R-CEL-110320", "R-RNO-5696397", "R-DME-5655862", "R-BTA-5696397", "R-CEL-5358565", "R-RNO-5656169", "R-BTA-110314", "R-PFA-69166", "R-DME-6782135", "R-BTA-69183", "R-MMU-5358565", "R-SPO-69166", "R-MMU-8866654", "R-SPO-176187", "R-DRE-6782210", "R-RNO-5656121", "R-DME-5651801", "R-HSA-69473", "R-PFA-110312", "R-BTA-6782135", "R-DDI-69183", "R-CEL-6782210", "R-HSA-9609690", "R-MMU-69183", "R-DDI-4615885", "R-HSA-8866654", "R-HSA-6804756", "R-CEL-6782135", "R-HSA-6804114", "R-SPO-110314", "R-SCE-69166", "R-BTA-8866654", "R-BTA-6782210", "R-RNO-174414", "R-RNO-4615885", "R-SCE-4615885", "R-SPO-4615885", "R-HSA-5685942", "R-PFA-5655862", "R-DRE-5656121", "R-PFA-5358565", "R-DRE-5696400", "R-DRE-6804114", "R-BTA-174437", "R-DRE-5656169", "R-DRE-69166", "R-CEL-69183", "R-BTA-5651801", "R-RNO-5685938", "R-SCE-5358565", "R-HSA-6782210", "R-BTA-5656169", "R-HSA-4615885", "R-BTA-5696400", "R-SCE-176187", "R-DRE-110312", "R-HSA-176187", "R-MMU-5696400", "R-DDI-5358565", "R-DME-176187", "R-MMU-5693607", "R-BTA-5655862", "R-BTA-4615885", "R-PFA-5656121", "R-DRE-5655862", "R-MMU-5656169", "R-BTA-69091", "R-HSA-5651801", "R-DDI-69166", "R-RNO-5685942", "R-DME-5656169", "R-MMU-5656121", "R-DRE-6782135", "R-BTA-5656121", "R-DME-5696400", "R-SPO-110320", "R-SPO-6782210", "R-MMU-69166", "R-RNO-5696400", "R-HSA-5696400", "R-DRE-5651801", "R-BTA-110320", "R-MMU-6804114", "R-DME-69166", "R-RNO-110312", "R-PFA-110320", "R-CEL-69091", "R-CEL-176187", "R-HSA-5693616", "R-SCE-69091", "R-HSA-5696397", "R-MMU-174417", "R-MMU-110320", "R-RNO-176187", "R-DME-5656121", "R-HSA-5655862", "R-HSA-174417", "R-HSA-9709570", "R-HSA-5693607", "R-SPO-69091", "R-DME-69183", "R-MMU-174437", "R-HSA-5656121", "R-CEL-110312", "R-RNO-6782210", "R-HSA-9610379", "R-PFA-4615885", "R-SCE-69183", "R-PFA-6782135", "R-MMU-5651801", "R-DME-110320", "R-SPO-5358565", "R-RNO-5693607", "R-DME-69091", "R-DRE-5685942", "R-HSA-110312", "R-PFA-69091", "R-RNO-69473", "R-DRE-174437", "R-HSA-1362277", "R-DRE-5358565", "R-MMU-176187", "R-MMU-6782210", "R-CEL-5651801", "R-MMU-5696397", "R-MMU-174411", "R-DDI-8866654", "R-HSA-110314", "R-SCE-6782135", "R-SPO-5651801", "R-DDI-6782135", "R-PFA-69183", "R-HSA-69205", "R-DME-6804114", "R-MMU-6782135", "R-SPO-5655862", "R-BTA-110312", "R-HSA-5358606", "R-DRE-4615885", "R-MMU-110312", "R-SPO-110312", "R-BTA-174417", "R-DME-5358565", "R-MMU-4615885", "R-DRE-8866654", "R-RNO-69166", "R-GGA-353303", "R-BTA-69166", "R-DME-110312", "R-CEL-5656169", "R-RNO-6804756", "R-HSA-5656169", "R-GGA-353299", "R-HSA-5685938", "R-RNO-174411", "R-CEL-4615885", "R-MMU-5655862", "R-SPO-5696397", "R-DRE-5696397", "R-RNO-5358565", "R-DDI-69091", "R-RNO-6782135", "R-CEL-5655862", "R-SPO-69183", "R-HSA-6782135", "R-MMU-5685942", "R-DRE-69091", "R-RNO-110320", "R-HSA-174411", "R-CEL-5696397", "R-HSA-69166", "R-RNO-69091", "R-DRE-110320", "R-SPO-5696400", "R-BTA-5358565", "R-HSA-69183", "R-BTA-5685942", "R-RNO-174417", "R-DRE-110314", "R-HSA-5358565", "R-HSA-69091", "R-BTA-174414", "R-SPO-6782135", "R-HSA-174437", "R-RNO-5651801", "R-HSA-110320", "R-MMU-69091"], "pathways": ["R-BTA-174411:r:Polymerase switching on the C-strand of the telomere", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", 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"R-MMU-69273", "R-BTA-69478", "R-HSA-68949", "R-MMU-187577", "R-RNO-68875", "R-DME-2995383", "R-MMU-2980767", "R-MMU-8852276", "R-BTA-176412", "R-MMU-68949", "R-BTA-176417", "R-HSA-2514853", "R-DME-2565942", "R-RNO-69478", "R-CEL-69656", "R-HSA-75035", "R-RNO-2565942", "R-CEL-2559586", "R-HSA-1538133", "R-MMU-6804116", "R-GGA-69273", "R-MMU-68875", "R-MMU-5693607", "R-HSA-176412", "R-CEL-69273", "R-MMU-176408", "R-MMU-176417", "R-HSA-156711", "R-MMU-6804757", "R-DME-176412", "R-HSA-2995383", "R-MMU-176412", "R-RNO-69273", "R-CEL-5689880", "R-HSA-9725371", "R-DME-3301854", "R-MMU-174184", "R-MMU-2299718", "R-DME-75035", "R-BTA-8878166", "R-MMU-6804114", "R-HSA-6804116", "R-RNO-2995383", "R-BTA-2980767", "R-HSA-69273", "R-CEL-187577", "R-BTA-75035", "R-DME-68875", "R-DME-69478", "R-MMU-2565942", "R-HSA-5693607", "R-BTA-2995383", "R-HSA-6804757", "R-HSA-2980767", "R-HSA-8878166", "R-HSA-2299718", "R-HSA-9825892", "R-CEL-69563", "R-HSA-176408", "R-MMU-68911", "R-BTA-3301854", "R-MMU-2559586", "R-MMU-8878166", "R-DME-8878166", "R-MMU-69478", "R-HSA-162658", "R-HSA-3301854", "R-CEL-69017", "R-HSA-4419969", "R-HSA-2465910", "R-BTA-176408", "R-GGA-2995383", "R-RNO-4419969", "R-HSA-2559586", "R-HSA-187577", "R-RNO-176417", "R-DME-6804114", "R-RNO-2500257", "R-HSA-2559582", "R-HSA-68875", "R-HSA-174184", "R-GGA-2500257", "R-MMU-174048", "R-HSA-171319", "R-HSA-2565942", "R-CEL-1538133", "R-RNO-8852276", "R-CEL-68911", "R-MMU-2995383", "R-DME-4419969", "R-MMU-2500257", "R-RNO-2299718", "R-BTA-69273", "R-HSA-2500257", "R-HSA-1362300", "R-BTA-174048", "R-HSA-8852276", "R-RNO-75035", "R-MMU-69563", "R-CEL-68949", "R-HSA-69017", "R-GGA-3301854", "R-BTA-4419969", "R-MMU-4419969", "R-DME-176417", "R-HSA-176417", "R-GGA-2980767"], "pathways": ["R-HSA-69563:r:p53-Dependent G1 DNA Damage Response", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-BTA-2299718:r:Condensation of Prophase Chromosomes", "R-MMU-1538133:r:G0 and Early G1", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-68875:r:Mitotic Prophase", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-RNO-176412:r:Phosphorylation of the APC/C", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-69478:r:G2/M DNA replication checkpoint", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-68911:r:G2 Phase", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-BTA-69478:r:G2/M DNA replication checkpoint", "R-HSA-68949:r:Orc1 removal from chromatin", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68875:r:Mitotic Prophase", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-MMU-68949:r:Orc1 removal from chromatin", "R-BTA-176417:r:Phosphorylation of Emi1", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-69478:r:G2/M DNA replication checkpoint", "R-CEL-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-2565942:r:Regulation of PLK1 Activity at 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proteases", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-2299718:r:Condensation of Prophase Chromosomes", "R-DME-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-BTA-8878166:r:Transcriptional regulation by RUNX2", "R-MMU-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-BTA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-DME-68875:r:Mitotic Prophase", "R-DME-69478:r:G2/M DNA replication checkpoint", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-8878166:r:Transcriptional regulation by RUNX2", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-CEL-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68911:r:G2 Phase", "R-BTA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-8878166:r:Transcriptional regulation by RUNX2", "R-DME-8878166:r:Transcriptional regulation by RUNX2", "R-MMU-69478:r:G2/M DNA replication checkpoint", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-GGA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-RNO-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-176417:r:Phosphorylation of Emi1", "R-DME-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-68875:r:Mitotic Prophase", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-1538133:r:G0 and Early G1", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-CEL-68911:r:G2 Phase", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-2299718:r:Condensation of Prophase Chromosomes", "R-BTA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-1362300:r:Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-MMU-69563:r:p53-Dependent G1 DNA Damage Response", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-GGA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-BTA-4419969:r:Depolymerization of the Nuclear Lamina", "R-MMU-4419969:r:Depolymerization of the Nuclear Lamina", "R-DME-176417:r:Phosphorylation of Emi1", "R-HSA-176417:r:Phosphorylation of Emi1", "R-GGA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7"], "type": "Family"}, "IPR046970": {"description": "TSP/COMP, coiled-coil domain superfamily", "go_ids": [], "go_terms": [], "name": "TSP/COMP_CC_sf", "pathway_ids": ["R-HSA-186797", "R-RNO-216083", "R-HSA-216083", "R-DRE-186797", "R-MMU-186797", "R-HSA-3000178", "R-RNO-186797", "R-MMU-216083", "R-BTA-216083"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-DRE-186797:r:Signaling by PDGF", "R-MMU-186797:r:Signaling by PDGF", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-216083:r:Integrin cell surface interactions", "R-BTA-216083:r:Integrin cell surface interactions"], "type": "Homologous_superfamily"}, "IPR046977": {"description": "rRNA (guanine-N(2)-)-methyltransferase RsmC/RlmG", "go_ids": ["GO:0008757"], "go_terms": ["GO:0008757:S-adenosylmethionine-dependent methyltransferase activity:F"], "name": "RsmC/RlmG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046980": {"description": "Glutathione-regulated potassium-efflux system ancillary protein KefG/KefF", "go_ids": [], "go_terms": [], "name": "KefG/KefF", "pathway_ids": ["PWY-7999", "PWY-7731"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "PWY-7731:t:superpathway of photosynthetic hydrogen production"], "type": "Family"}, "IPR046981": {"description": "Glucose-1-phosphate cytidylyltransferase", "go_ids": ["GO:0047343", "GO:0009243"], "go_terms": ["GO:0047343:glucose-1-phosphate cytidylyltransferase activity:F", "GO:0009243:O antigen biosynthetic process:P"], "name": "G1P_cyt_trans", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046982": {"description": "Bridging integrator 3/RVS161-like", "go_ids": ["GO:0006897", "GO:0051666"], "go_terms": ["GO:0006897:endocytosis:P", "GO:0051666:actin cortical patch localization:P"], "name": "BIN3/RVS161-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR046985": {"description": "Inositol 5-phosphatase", "go_ids": ["GO:0046856"], "go_terms": ["GO:0046856:phosphatidylinositol dephosphorylation:P"], "name": "IP5", "pathway_ids": ["PWY-6368", "R-HSA-9013409", "R-MMU-8856828", "R-SCE-1855204", "R-RNO-9013409", "R-HSA-8856828", "R-MMU-432722", "R-MMU-9013409", "R-SPO-1660499", "R-RNO-1660514", "R-HSA-1660499", "R-SPO-1855204", "R-HSA-9013423", "R-SPO-1855183", "R-SPO-9013409", "R-HSA-1855183", "R-MMU-1660514", "R-RNO-8856828", "R-MMU-1855183", "R-HSA-432722", "R-MMU-1855204", "R-RNO-432722", "R-RNO-1855183", "R-CEL-8856828", "R-CEL-1855204", "R-SPO-1660514", "R-SCE-1660499", "R-CEL-1855183", "R-HSA-1660514", "R-MMU-1660499", "R-SCE-1855183", "R-RNO-9013423", "R-MMU-9013423", "R-RNO-1660499", "R-HSA-1855204", "R-RNO-1855204", "R-CEL-1660499"], "pathways": ["PWY-6368:t:3-phosphoinositide degradation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SCE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SPO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-SPO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-SPO-9013409:r:RHOJ GTPase cycle", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SCE-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Family"}, "IPR046987": {"description": "Unconventional class IX myosin", "go_ids": ["GO:0000146", "GO:0005096", "GO:0035556"], "go_terms": ["GO:0000146:microfilament motor activity:F", "GO:0005096:GTPase activator activity:F", "GO:0035556:intracellular signal transduction:P"], "name": "Myo9", "pathway_ids": ["R-RNO-9013026", "R-MMU-9035034", "R-MMU-9013106", "R-RNO-9035034", "R-DRE-9013424", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013424", "R-RNO-9013149", "R-HSA-2029482", "R-HSA-9013424", "R-HSA-9013106", "R-RNO-9013148", "R-MMU-8985586", "R-MMU-9013148", "R-MMU-2029482", "R-RNO-2029482", "R-HSA-8985586", "R-HSA-9013149", "R-HSA-8980692", "R-RNO-9013424", "R-HSA-9035034", "R-MMU-9013026", "R-MMU-9013149", "R-HSA-9013148", "R-HSA-9013026", "R-DRE-9013026", "R-DRE-8980692", "R-RNO-8985586", "R-RNO-9013106", "R-HSA-9664422"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-DRE-9013424:r:RHOV GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-9013026:r:RHOB GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-RNO-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis"], "type": "Family"}, "IPR046995": {"description": "Regulator of G-protein signaling 10/12/14-like", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "RGS10/12/14-like", "pathway_ids": ["R-DME-418594", "R-HSA-418594", "R-CEL-416476", "R-CEL-418594", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-DME-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-CEL-416476:r:G alpha (q) signalling events", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR046997": {"description": "Isocitrate dehydrogenase/Hypothetical protein TT1725, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Isocitrate_DH_TT1725_C_sf", "pathway_ids": ["PWY-6549", "PWY-7254", "PWY-7124", "PWY-5913", "PWY-7268", "PWY-6728", "PWY-6969"], "pathways": ["PWY-6549:t:nitrogen remobilization from senescing leaves", "PWY-7254:t:TCA cycle VII (acetate-producers)", "PWY-7124:t:ethene biosynthesis V (engineered)", "PWY-5913:t:partial TCA cycle (obligate autotrophs)", "PWY-7268:t:cytosolic NADPH production (yeast)", "PWY-6728:t:methylaspartate cycle", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)"], "type": "Homologous_superfamily"}, "IPR047001": {"description": "tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain", "go_ids": [], "go_terms": [], "name": "MnmG_C_subdom", "pathway_ids": ["R-HSA-6787450"], "pathways": ["R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR047002": {"description": "T-complex protein 10, C-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Tcp10_C_sf", "pathway_ids": ["R-HSA-380320", "R-HSA-6804115", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-6804115", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Homologous_superfamily"}, "IPR047007": {"description": "5'-3' exoribonuclease 1, D1 domain superfamily", "go_ids": [], "go_terms": [], "name": "XRN1_D1_sf", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-MMU-450513", "R-HSA-450513", "R-SCE-450513", "R-HSA-9918487", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Homologous_superfamily"}, "IPR047008": {"description": "5'-3' exoribonuclease 1, SH3-like domain superfamily", "go_ids": [], "go_terms": [], "name": "XRN1_SH3_sf", "pathway_ids": ["R-MMU-450385", "R-HSA-450385", "R-MMU-450513", "R-HSA-450513", "R-SCE-450513", "R-HSA-9918487", "R-SCE-450385", "R-HSA-430039"], "pathways": ["R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Homologous_superfamily"}, "IPR047012": {"description": "Intercellular adhesion molecule/vascular cell adhesion molecule", "go_ids": ["GO:0005178", "GO:0007155"], "go_terms": ["GO:0005178:integrin binding:F", "GO:0007155:cell adhesion:P"], "name": "ICAM_VCAM", "pathway_ids": ["R-HSA-216083", "R-RNO-216083", "R-MMU-5621575", "R-RNO-198933", "R-CFA-198933", "R-HSA-6785807", "R-CFA-216083", "R-MMU-198933", "R-HSA-5621575", "R-HSA-877300", "R-MMU-216083", "R-HSA-198933", "R-HSA-6783783"], "pathways": ["R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CFA-216083:r:Integrin cell surface interactions", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-6783783:r:Interleukin-10 signaling"], "type": "Family"}, "IPR047016": {"description": "Regulator of G protein signaling 6/7/9/11", "go_ids": ["GO:0008277"], "go_terms": ["GO:0008277:regulation of G protein-coupled receptor signaling pathway:P"], "name": "RGS6/7/9/11", "pathway_ids": ["R-BTA-418594", "R-HSA-418594", "R-HSA-2514859", "R-MMU-2514859", "R-RNO-6814122", "R-HSA-6814122", "R-RNO-2514859", "R-BTA-6814122", "R-CEL-418594", "R-MMU-418594", "R-CEL-6814122", "R-RNO-418594", "R-MMU-6814122"], "pathways": ["R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-418594:r:G alpha (i) signalling events", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-418594:r:G alpha (i) signalling events", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Family"}, "IPR047017": {"description": "Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily", "go_ids": [], "go_terms": [], "name": "RGS6/7/9/11_DHEX_sf", "pathway_ids": ["R-BTA-418594", "R-HSA-418594", "R-HSA-2514859", "R-MMU-2514859", "R-RNO-6814122", "R-HSA-6814122", "R-RNO-2514859", "R-BTA-6814122", "R-CEL-418594", "R-MMU-418594", "R-CEL-6814122", "R-RNO-418594", "R-MMU-6814122"], "pathways": ["R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-418594:r:G alpha (i) signalling events", "R-CEL-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-RNO-418594:r:G alpha (i) signalling events", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Homologous_superfamily"}, "IPR047021": {"description": "RNA exonuclease REXO1/REXO3/REXO4-like", "go_ids": ["GO:0004527"], "go_terms": ["GO:0004527:exonuclease activity:F"], "name": "REXO1/3/4-like", "pathway_ids": ["R-MMU-6791226", "R-HSA-909733", "R-BTA-6791226", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR047036": {"description": "Elongation factor 3, four helical bundle domain superfamily", "go_ids": [], "go_terms": [], "name": "EF3_4HB_sf", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Homologous_superfamily"}, "IPR047038": {"description": "Elongation Factor 3, chromodomain-like insertion superfamily", "go_ids": [], "go_terms": [], "name": "eEF3_chromodomain-like_sf", "pathway_ids": ["PWY-7250", "R-SCE-382556", "R-SPO-382556"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-SPO-382556:r:ABC-family proteins mediated transport"], "type": "Homologous_superfamily"}, "IPR047046": {"description": "NTP pyrophosphohydrolase MazG-related, YpjD/YvdC", "go_ids": [], "go_terms": [], "name": "YpjD/YvdC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047048": {"description": "16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "TlyA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047053": {"description": "Kalirin/Triple functional domain protein, SH3 domain 2", "go_ids": [], "go_terms": [], "name": "Kalirin_TRIO_SH3_2", "pathway_ids": ["R-MMU-416476", "R-HSA-9013409", "R-RNO-9013409", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-RNO-5687128", "R-MMU-9013409", "R-HSA-416476", "R-HSA-418885", "R-MMU-9013148", "R-MMU-9013404", "R-DRE-9013404", "R-HSA-3928662", "R-HSA-9013423", "R-DRE-9013423", "R-RNO-416482", "R-HSA-9013148", "R-RNO-3928662", "R-DRE-9013149", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-416476", "R-RNO-193648", "R-HSA-193648", "R-DRE-9013408", "R-DRE-9013409", "R-DRE-416482", "R-HSA-416482", "R-RNO-9013148", "R-RNO-418885", "R-RNO-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-HSA-8980692", "R-HSA-5687128", "R-MMU-416482", "R-MMU-3928662", "R-MMU-193648", "R-DRE-8980692", "R-DRE-416476", "R-MMU-5687128", "R-DRE-193648", "R-MMU-9013149", "R-MMU-418885"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-193648:r:NRAGE signals death through JNK", "R-DRE-9013408:r:RHOG GTPase cycle", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-418885:r:DCC mediated attractive signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-193648:r:NRAGE signals death through JNK", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DRE-416476:r:G alpha (q) signalling events", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR047055": {"description": "Motility protein A-like", "go_ids": ["GO:0071978", "GO:0006935"], "go_terms": ["GO:0071978:bacterial-type flagellum-dependent swarming motility:P", "GO:0006935:chemotaxis:P"], "name": "MotA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047057": {"description": "MerR transcriptional regulator", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "MerR_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047086": {"description": "Splicing factor 1, helix-hairpin domain superfamily", "go_ids": [], "go_terms": [], "name": "SF1-HH_sf", "pathway_ids": ["R-HSA-72163", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Homologous_superfamily"}, "IPR047088": {"description": "Origin recognition complex subunit 5, C-terminal", "go_ids": [], "go_terms": [], "name": "ORC5_C", "pathway_ids": ["R-DDI-68689", "R-SPO-176187", "R-HSA-68949", "R-SPO-68616", "R-MMU-68962", "R-HSA-113507", "R-MMU-68949", "R-DDI-68616", "R-HSA-68689", "R-SCE-68962", "R-DME-68616", "R-SCE-68616", "R-HSA-68616", "R-DME-68689", "R-DME-68962", "R-DDI-68962", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-DME-176187", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949", "R-SCE-176187", "R-HSA-176187", "R-DME-68949", "R-HSA-68867"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR047091": {"description": "Ethylene insensitive 3-like, DNA-binding domain", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "EIN3-like_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047092": {"description": "Subtelomeric hrmA-associated cluster protein AFUB_079030/YDR124W-like, helical bundle domain", "go_ids": [], "go_terms": [], "name": "AFUB_07903/YDR124W-like_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047099": {"description": "Nop5, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Nop5_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR047103": {"description": "Maltose transport system permease protein MalF, P2 domain superfamily", "go_ids": [], "go_terms": [], "name": "MalF_P2_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR047104": {"description": "Bridge-like lipid transfer protein family member 1, N-terminal", "go_ids": [], "go_terms": [], "name": "BLTP1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047108": {"description": "Plk4-like, second cryptic polo-box domain superfamily", "go_ids": [], "go_terms": [], "name": "Plk4-like_POLO_box_2_sf", "pathway_ids": ["R-DRE-380320", "R-MMU-380259", "R-RNO-8854518", "R-HSA-380284", "R-MMU-380270", "R-XTR-380270", "R-XTR-380284", "R-XTR-8854518", "R-RNO-5620912", "R-HSA-380270", "R-HSA-8854518", "R-XTR-380259", "R-XTR-380320", "R-MMU-380284", "R-BTA-380259", "R-RNO-380259", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-MMU-2565942", "R-XTR-5620912", "R-MMU-380320", "R-BTA-8854518", "R-BTA-380270", "R-BTA-2565942", "R-RNO-2565942", "R-BTA-5620912", "R-RNO-380284", "R-XTR-2565942", "R-BTA-380320", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-BTA-380284", "R-RNO-380270"], "pathways": ["R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Homologous_superfamily"}, "IPR047109": {"description": "Cinnamyl alcohol dehydrogenase-like", "go_ids": ["GO:0016616"], "go_terms": ["GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "CAD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047110": {"description": "Succinate-semialdehyde dehydrogenase [NADP(+)] GABD/Sad-like", "go_ids": [], "go_terms": [], "name": "GABD/Sad-like", "pathway_ids": ["PWY-6537", "PWY-6993"], "pathways": ["PWY-6537:t:4-aminobutanoate degradation II", "PWY-6993:t:nicotine degradation II (pyrrolidine pathway)"], "type": "Family"}, "IPR047111": {"description": "Uncharacterized protein YbaP-like", "go_ids": [], "go_terms": [], "name": "YbaP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047112": {"description": "ATP-dependent DNA helicase RecG/Transcription-repair-coupling factor", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "RecG/Mfd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047113": {"description": "Proliferation-associated protein 2G4/ARX1", "go_ids": [], "go_terms": [], "name": "PA2G4/ARX1", "pathway_ids": ["R-SCE-6798695", "R-MMU-6798695", "R-DDI-6798695", "R-SPO-6798695", "R-HSA-6798695", "R-RNO-6798695"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR047114": {"description": "Protein YciF", "go_ids": [], "go_terms": [], "name": "YciF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047115": {"description": "Arylsulfatase B", "go_ids": ["GO:0008484"], "go_terms": ["GO:0008484:sulfuric ester hydrolase activity:F"], "name": "ARSB", "pathway_ids": ["PWY-6821", "R-HSA-2024101", "R-MMU-9840310", "R-RNO-9840310", "R-HSA-6798695", "R-RNO-2024101", "R-HSA-9840310", "R-MMU-2024101", "R-MMU-6798695", "R-HSA-1663150", "R-RNO-1663150", "R-MMU-1663150", "R-HSA-2206285", "R-RNO-6798695"], "pathways": ["PWY-6821:t:kappa-carrageenan degradation", "R-HSA-2024101:r:CS/DS degradation", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-1663150:r:The activation of arylsulfatases", "R-RNO-1663150:r:The activation of arylsulfatases", "R-MMU-1663150:r:The activation of arylsulfatases", "R-HSA-2206285:r:MPS VI - Maroteaux-Lamy syndrome", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR047117": {"description": "Proline-rich receptor-like protein kinase PERK1-13-like", "go_ids": [], "go_terms": [], "name": "PERK1-13-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047118": {"description": "F-box only protein 7", "go_ids": ["GO:0019901"], "go_terms": ["GO:0019901:protein kinase binding:F"], "name": "Fbxo7", "pathway_ids": ["R-MMU-8951664", "R-HSA-983168", "R-RNO-983168", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR047119": {"description": "Forkhead box protein N2/3-like", "go_ids": ["GO:0003700", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "FOXN2/3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047120": {"description": "Prickle/Espinas/Testin", "go_ids": [], "go_terms": [], "name": "Pk/Esn/Tes", "pathway_ids": ["R-XTR-4608870", "R-RNO-4608870", "R-DME-350369", "R-DME-350411", "R-HSA-4608870", "R-HSA-5683826", "R-BTA-5683826", "R-DME-350368", "R-DME-350480", "R-DME-4608870", "R-SSC-5683826", "R-MMU-4608870", "R-DME-450728", "R-DME-350376", "R-MMU-5683826"], "pathways": ["R-XTR-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-DME-350369:r:Negative feedback loop regulates asymmetric localisation", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5683826:r:Surfactant metabolism", "R-BTA-5683826:r:Surfactant metabolism", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SSC-5683826:r:Surfactant metabolism", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DME-450728:r:Inhibition of actin polymerization", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex", "R-MMU-5683826:r:Surfactant metabolism"], "type": "Family"}, "IPR047121": {"description": "Uncharacterized protein YjlB-like", "go_ids": [], "go_terms": [], "name": "YjiB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047122": {"description": "Trans-enoyl reductase-like", "go_ids": ["GO:0016651"], "go_terms": ["GO:0016651:oxidoreductase activity, acting on NAD(P)H:F"], "name": "Trans-enoyl_RdTase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047123": {"description": "Myeloid-associated differentiation marker-like", "go_ids": [], "go_terms": [], "name": "MYADM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047124": {"description": "Uracil-DNA glycosylase-like HI_0220.2", "go_ids": [], "go_terms": [], "name": "HI_0220.2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047125": {"description": "Dynactin subunit 5", "go_ids": [], "go_terms": [], "name": "DCTN5", "pathway_ids": ["R-HSA-2132295", "R-SSC-2132295", "R-SSC-6807878", "R-SSC-3371497", "R-DDI-6807878", "R-MMU-2132295", "R-HSA-6807878", "R-HSA-3371497", "R-MMU-6807878", "R-HSA-6811436", "R-MMU-3371497", "R-MMU-6811436"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-SSC-2132295:r:MHC class II antigen presentation", "R-SSC-6807878:r:COPI-mediated anterograde transport", "R-SSC-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR047126": {"description": "RING finger protein 141-like", "go_ids": [], "go_terms": [], "name": "RNF141-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047127": {"description": "Mutator MutT-like", "go_ids": ["GO:0006281"], "go_terms": ["GO:0006281:DNA repair:P"], "name": "MutT-like", "pathway_ids": ["PWY-6502"], "pathways": ["PWY-6502:t:8-oxo-(d)GTP detoxification I"], "type": "Family"}, "IPR047128": {"description": "Phytanoyl-CoA dioxygenase", "go_ids": ["GO:0001561", "GO:0048244"], "go_terms": ["GO:0001561:fatty acid alpha-oxidation:P", "GO:0048244:phytanoyl-CoA dioxygenase activity:F"], "name": "PhyH", "pathway_ids": ["R-BTA-9033241", "R-BTA-389599", "R-CEL-389599", "R-RNO-9033241", "R-HSA-389599", "R-RNO-389599", "R-SCE-9033241", "R-HSA-9033500", "R-MMU-9033241", "R-SCE-389599", "R-HSA-9033241", "R-MMU-389599"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-BTA-389599:r:Alpha-oxidation of phytanate", "R-CEL-389599:r:Alpha-oxidation of phytanate", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-389599:r:Alpha-oxidation of phytanate", "R-RNO-389599:r:Alpha-oxidation of phytanate", "R-SCE-9033241:r:Peroxisomal protein import", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-MMU-9033241:r:Peroxisomal protein import", "R-SCE-389599:r:Alpha-oxidation of phytanate", "R-HSA-9033241:r:Peroxisomal protein import", "R-MMU-389599:r:Alpha-oxidation of phytanate"], "type": "Family"}, "IPR047129": {"description": "Serine/Threonine protein phosphatase PP2A-like", "go_ids": ["GO:0004722"], "go_terms": ["GO:0004722:protein serine/threonine phosphatase activity:F"], "name": "PPA2-like", "pathway_ids": ["R-SSC-5673000", "R-DME-69273", "R-BTA-975957", "R-HSA-9833482", "R-MMU-6811558", "R-CEL-195253", "R-SCE-204005", "R-SSC-69231", "R-CEL-5673000", "R-SPO-975957", "R-MMU-68877", "R-HSA-69231", "R-SSC-4641262", "R-BTA-6804757", "R-SSC-9833482", "R-HSA-5673000", "R-RNO-6811558", "R-BTA-6811558", "R-HSA-5467337", "R-BTA-2500257", "R-DME-1295596", "R-SSC-196299", "R-DDI-198753", "R-CEL-69231", "R-SSC-1295596", "R-RNO-5673000", "R-HSA-5358752", "R-HSA-198753", "R-DDI-204005", "R-SPO-6811558", "R-HSA-163767", "R-HSA-202670", "R-MMU-196299", "R-SSC-389356", "R-DDI-113501", "R-DME-209461", "R-SSC-432142", "R-CEL-2995383", "R-MMU-5673000", "R-SCE-202670", "R-HSA-141444", "R-RNO-5675221", "R-RNO-5663220", "R-RNO-180024", "R-RNO-202670", "R-DME-5675221", "R-HSA-9634600", "R-BTA-5675221", "R-MMU-171319", "R-RNO-6804757", "R-DME-432620", "R-HSA-389356", "R-HSA-1295596", "R-SSC-975957", "R-MMU-4641262", "R-BTA-4641262", "R-SCE-389513", "R-CEL-6811558", "R-MMU-69273", "R-BTA-9648025", "R-BTA-9833482", "R-MMU-9860927", "R-RNO-141444", "R-MMU-5663220", "R-MMU-5675221", "R-DRE-5693607", "R-DME-432553", "R-HSA-2467813", "R-RNO-4641262", "R-DME-2995383", "R-BTA-195253", "R-SSC-202670", "R-HSA-196299", "R-RNO-9860927", "R-DME-209396", "R-HSA-68877", "R-HSA-4641262", "R-SSC-195253", "R-SSC-2995383", "R-SSC-9860927", "R-MMU-202670", "R-DME-389513", "R-MMU-195253", "R-SSC-9648025", "R-HSA-389513", "R-HSA-195253", "R-CEL-69273", "R-SSC-389513", "R-HSA-113501", "R-MMU-5693607", "R-DME-209360", "R-RNO-68877", "R-DDI-9833482", "R-DDI-69231", "R-MMU-975957", "R-MMU-6804757", 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"R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR047135": {"description": "Uncharacterized transporter YisQ", "go_ids": [], "go_terms": [], "name": "YsiQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047136": {"description": "Adenylosuccinate lyase PurB, bacteria", "go_ids": [], "go_terms": [], "name": "PurB_bact", "pathway_ids": ["PWY-7219", "PWY-7234", "PWY-6124", "PWY-6123", "PWY-8289"], "pathways": ["PWY-7219:t:adenosine ribonucleotides de novo biosynthesis", "PWY-7234:t:inosine-5'-phosphate biosynthesis III", "PWY-6124:t:inosine-5'-phosphate biosynthesis II", "PWY-6123:t:inosine-5'-phosphate biosynthesis I", "PWY-8289:t:dZTP biosynthesis"], "type": "Family"}, "IPR047137": {"description": "Polyketide cyclase/dehydrase-like ORF3", "go_ids": [], "go_terms": [], "name": "ORF3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047138": {"description": "Rhophilin-1/2", "go_ids": [], "go_terms": [], "name": "RHPN1_2", "pathway_ids": ["R-BTA-5666185", "R-HSA-8980692", "R-MMU-9013026", "R-MMU-8980692", "R-HSA-5666185", "R-DRE-5666185", "R-DRE-9013026", "R-BTA-8980692", "R-DRE-8980692", "R-HSA-9013026", "R-MMU-5666185"], "pathways": ["R-BTA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DRE-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins", "R-DRE-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins"], "type": "Family"}, "IPR047139": {"description": "tRNA endonuclease ANKZF1/VMS1", "go_ids": [], "go_terms": [], "name": "ANKZ1/VMS1", "pathway_ids": ["R-HSA-9954709"], "pathways": ["R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Family"}, "IPR047140": {"description": "Low amplitude and bright protein LabA", "go_ids": [], "go_terms": [], "name": "LabA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047141": {"description": "Stealth family", "go_ids": [], "go_terms": [], "name": "Stealth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047142": {"description": "Oryzines biosynthesis cluster protein J/Cupin-domain-containing oxidoreductase virC-like", "go_ids": [], "go_terms": [], "name": "OryJ/VirC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047143": {"description": "G-protein coupled estrogen receptor 1-like", "go_ids": [], "go_terms": [], "name": "GPER1-like", "pathway_ids": ["R-HSA-9634597", "R-DRE-418594", "R-DRE-375276", "R-HSA-418594", "R-HSA-380108", "R-RNO-375276", "R-HSA-375276", "R-MMU-9634597", "R-MMU-380108", "R-RNO-380108", "R-MMU-375276", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-HSA-9634597:r:GPER1 signaling", "R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-375276:r:Peptide ligand-binding receptors", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-380108:r:Chemokine receptors bind chemokines", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-9634597:r:GPER1 signaling", "R-MMU-380108:r:Chemokine receptors bind chemokines", "R-RNO-380108:r:Chemokine receptors bind chemokines", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR047144": {"description": "BCL-6 corepressor-like", "go_ids": [], "go_terms": [], "name": "BCOR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047145": {"description": "FERM domain-containing protein 6-like", "go_ids": [], "go_terms": [], "name": "FRMD6-like", "pathway_ids": ["R-DME-451806"], "pathways": ["R-DME-451806:r:Phosphorylation-independent inhibition of 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"R-MMU-176417:r:Phosphorylation of Emi1", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DRE-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DRE-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-176417:r:Phosphorylation of Emi1", "R-DRE-68881:r:Mitotic Metaphase/Anaphase Transition", "R-HSA-68881:r:Mitotic Metaphase/Anaphase Transition"], "type": "Family"}, "IPR047148": {"description": "85/88 kDa calcium-independent phospholipase A2", "go_ids": [], "go_terms": [], "name": "PLPL9", "pathway_ids": ["PWY-8411", "PWY-8051", "PWY-7783", "PWY-7416", "PWY-8398", "PWY-7417", "PWY-8400", "PWY-8399", "PWY-6733", "PWY-7409", "PWY-6803", "PWY-321", "PWY-5996", "PWY-8395", "PWY-5972", "PWY-7723", "PWY-8356", "PWY-8357", "PWY-8355", "PWY-8396", "PWY-8413", "PWY-8397", "PWY-8053", "PWY-1121", "PWY-8412", "PWY-8410", "R-RNO-6811436", "R-RNO-1482788", "R-RNO-2029485", "R-HSA-1482839", "R-HSA-1482798", "R-MMU-1482788", "R-MMU-2029485", "R-HSA-2029485", "R-RNO-1482839", "R-MMU-1482839", "R-HSA-6811436", "R-MMU-6811436", "R-HSA-1482788"], "pathways": ["PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-8051:t:anandamide biosynthesis I", "PWY-7783:t:plasmalogen degradation", "PWY-7416:t:phospholipid remodeling (phosphatidylcholine, yeast)", "PWY-8398:t:alpha-linolenate metabolites biosynthesis", "PWY-7417:t:phospholipid remodeling (phosphatidate, yeast)", "PWY-8400:t:docosahexaenoate metabolites biosynthesis", "PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-7409:t:phospholipid remodeling (phosphatidylethanolamine, yeast)", "PWY-6803:t:phosphatidylcholine acyl editing", "PWY-321:t:cutin biosynthesis", "PWY-5996:t:oleate biosynthesis II (animals and fungi)", "PWY-8395:t:linoleate metabolites biosynthesis", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-7723:t:bacterial bioluminescence", "PWY-8356:t:maresin biosynthesis", "PWY-8357:t:protectin biosynthesis", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-8413:t:representative whole plasma EPA-derived icosanoids", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-1121:t:suberin monomers biosynthesis", "PWY-8412:t:representative whole plasma DHA-derived icosanoids", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Family"}, "IPR047149": {"description": "Kinesin-like protein KIF11-like", "go_ids": [], "go_terms": [], "name": "KIF11-like", "pathway_ids": ["R-HSA-2132295", "R-BTA-68884", "R-BTA-983189", "R-MMU-68884", "R-MMU-983189", "R-DDI-983189", "R-SPO-983189", "R-XTR-983189", "R-DME-983189", "R-HSA-6811434", "R-XTR-6811434", "R-HSA-68884", "R-HSA-983189", "R-MMU-2132295", "R-BTA-2132295", "R-SCE-983189", "R-MMU-6811434"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-BTA-68884:r:Mitotic Telophase/Cytokinesis", "R-BTA-983189:r:Kinesins", "R-MMU-68884:r:Mitotic Telophase/Cytokinesis", "R-MMU-983189:r:Kinesins", "R-DDI-983189:r:Kinesins", "R-SPO-983189:r:Kinesins", "R-XTR-983189:r:Kinesins", "R-DME-983189:r:Kinesins", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-XTR-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-68884:r:Mitotic Telophase/Cytokinesis", "R-HSA-983189:r:Kinesins", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SCE-983189:r:Kinesins", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR047150": {"description": "SGT", "go_ids": [], "go_terms": [], "name": "SGT", "pathway_ids": ["R-MMU-9609523", "R-SCE-9609523", "R-HSA-9609523", "R-DDI-9609523", "R-SPO-9609523", "R-BTA-9609523", "R-RNO-9609523"], "pathways": ["R-MMU-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SCE-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-DDI-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-SPO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-BTA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-RNO-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Family"}, "IPR047151": {"description": "Zinc phosphodiesterase ELAC protein 2-like", "go_ids": ["GO:0042781"], "go_terms": ["GO:0042781:3'-tRNA processing endoribonuclease activity:F"], "name": "RNZ2-like", "pathway_ids": ["R-HSA-6785470", "R-HSA-8868766", "R-HSA-6784531", "R-HSA-9708296"], "pathways": ["R-HSA-6785470:r:tRNA processing in the mitochondrion", "R-HSA-8868766:r:rRNA processing in the mitochondrion", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis"], "type": "Family"}, 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"R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-8948747:r:Regulation of PTEN localization", "R-MMU-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Family"}, "IPR047154": {"description": "Ubiquitin-like protein 4A-like", "go_ids": ["GO:0006620"], "go_terms": 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[], "name": "PHRF1/Atg35", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047160": {"description": "G-protein coupled receptor 183-like", "go_ids": ["GO:0008142", "GO:0004930"], "go_terms": ["GO:0008142:oxysterol binding:F", "GO:0004930:G protein-coupled receptor activity:F"], "name": "GP183-like", "pathway_ids": ["R-DRE-418594", "R-HSA-418594", "R-BTA-418594", "R-RNO-373076", "R-BTA-373076", "R-HSA-373076", "R-DRE-373076", "R-MMU-418594", "R-RNO-418594", "R-MMU-373076"], "pathways": ["R-DRE-418594:r:G alpha (i) signalling events", "R-HSA-418594:r:G alpha (i) signalling events", "R-BTA-418594:r:G alpha (i) signalling events", "R-RNO-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-BTA-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-HSA-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-DRE-373076:r:Class A/1 (Rhodopsin-like receptors)", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events", "R-MMU-373076:r:Class A/1 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"R-MMU-9013404:r:RAC2 GTPase cycle", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DME-3928664:r:Ephrin signaling", "R-HSA-9619229:r:Activation of RAC1 downstream of NMDARs", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-MMU-3928664:r:Ephrin signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-3928664:r:Ephrin signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-RNO-3928664:r:Ephrin signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Family"}, "IPR047163": {"description": "Apoptosis-stimulating of p53 protein 1/2", "go_ids": ["GO:0002039", "GO:0042981"], "go_terms": ["GO:0002039:p53 binding:F", "GO:0042981:regulation of apoptotic process:P"], "name": "ASPP1/2", "pathway_ids": ["R-MMU-6804759", "R-HSA-6803204", "R-HSA-6803205", "R-HSA-6803211", "R-HSA-139915", "R-HSA-6804759"], "pathways": ["R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors"], "type": "Family"}, "IPR047164": {"description": "OX-2 membrane glycoprotein-like", "go_ids": ["GO:0098632"], "go_terms": ["GO:0098632:cell-cell adhesion mediator activity:F"], "name": "OX2G-like", "pathway_ids": ["R-RNO-198933", "R-HSA-198933", "R-MMU-198933"], "pathways": ["R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR047165": {"description": "Rho GTPase-activating protein 17/44/SH3BP1-like", "go_ids": ["GO:0043547", "GO:0005096"], "go_terms": ["GO:0043547:positive regulation of GTPase activity:P", "GO:0005096:GTPase activator activity:F"], "name": "RHG17/44/SH3BP1-like", "pathway_ids": ["R-HSA-9013405", "R-DME-9013149", "R-DME-8980692", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-9013149", "R-RNO-9013148", "R-MMU-9013148", "R-MMU-9013404", "R-DDI-9013149", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-RNO-9013423", "R-DME-9013148", "R-HSA-8980692", "R-MMU-9013406", "R-HSA-9013148", "R-DME-9013406", "R-DDI-9013423", "R-DDI-9013404", "R-HSA-9013406", "R-RNO-9013404", "R-RNO-9013406", "R-MMU-9013149", "R-DME-9013423"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR047167": {"description": "Nuclear Factor Erythroid-derived 2-like", "go_ids": ["GO:0003700", "GO:0006357", "GO:0000978"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0006357:regulation of transcription by RNA polymerase II:P", "GO:0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding:F"], "name": "NFE2-like", "pathway_ids": ["R-HSA-8951664", "R-HSA-9818035", "R-DME-8951664", "R-HSA-8936459", "R-HSA-9818749", "R-MMU-9755511", "R-MMU-983231", "R-BTA-983231", "R-MMU-8951664", "R-HSA-9818025", "R-HSA-9818030", "R-MMU-9759194", "R-RNO-983231", "R-DME-983231", "R-HSA-9759194", "R-MMU-9762114", "R-HSA-9762114", "R-HSA-9818028", "R-DME-9762114", "R-CEL-9755511", "R-RNO-9755511", "R-HSA-983231", "R-HSA-9707616", "R-HSA-9755511", "R-HSA-9679191", "R-DME-9759194", "R-RNO-9759194", "R-CEL-9759194", "R-DME-9755511", "R-HSA-9909649", "R-HSA-9818026", "R-RNO-8951664", "R-RNO-9762114", "R-HSA-9707587", "R-HSA-9818032", "R-CEL-9762114", "R-CEL-8951664", "R-HSA-9818027"], "pathways": ["R-HSA-8951664:r:Neddylation", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-DME-8951664:r:Neddylation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-8951664:r:Neddylation", "R-HSA-9818025:r:NFE2L2 regulating TCA cycle genes", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9707616:r:Heme signaling", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-9759194:r:Nuclear events mediated by NFE2L2", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-RNO-8951664:r:Neddylation", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9707587:r:Regulation of HMOX1 expression and activity", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes"], "type": "Family"}, "IPR047168": {"description": "PX domain-containing protein LEC1-like", "go_ids": [], "go_terms": [], "name": "LEC1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047169": {"description": "Insulin gene enhancer protein ISL-1/2-like", "go_ids": ["GO:0048665", "GO:0045944", "GO:0000981"], "go_terms": ["GO:0048665:neuron fate specification:P", "GO:0045944:positive regulation of transcription by RNA polymerase II:P", "GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific:F"], "name": "ISL1/2-like", "pathway_ids": ["R-HSA-9733709", "R-HSA-400511", "R-HSA-9010553"], "pathways": ["R-HSA-9733709:r:Cardiogenesis", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs"], "type": "Family"}, "IPR047170": {"description": "Tyrosine-protein phosphatase non-receptor type 12/18/22", "go_ids": ["GO:0004726"], "go_terms": ["GO:0004726:non-membrane spanning protein tyrosine phosphatase activity:F"], "name": "PTN12/18/22", "pathway_ids": ["R-MMU-8863795", "R-HSA-186797", "R-MMU-182971", "R-HSA-9008059", "R-HSA-202427", "R-HSA-182971", "R-HSA-8863795", "R-HSA-9634285", "R-MMU-202427", "R-MMU-1250196", "R-HSA-1250196", "R-HSA-202430", "R-MMU-186797", "R-MMU-202430"], "pathways": ["R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-186797:r:Signaling by PDGF", "R-MMU-182971:r:EGFR downregulation", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-182971:r:EGFR downregulation", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse"], "type": "Family"}, "IPR047171": {"description": "Bromodomain adjacent to zinc finger domain protein 1A", "go_ids": ["GO:0006338"], "go_terms": ["GO:0006338:chromatin remodeling:P"], "name": "BAZ1A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047172": {"description": "Ajuba-like", "go_ids": [], "go_terms": [], "name": "Ajuba-like", "pathway_ids": ["R-RNO-1234176", "R-HSA-5617472", "R-RNO-2565942", "R-BTA-2565942", "R-BTA-9841922", "R-HSA-2565942", "R-DME-9841922", "R-BTA-1234176", "R-XTR-1234176", "R-RNO-9841922", "R-DME-1234176", "R-DRE-1234176", "R-MMU-2565942", "R-MMU-1234176", "R-HSA-9841922", "R-HSA-1234176"], "pathways": ["R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-XTR-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DRE-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Family"}, "IPR047173": {"description": "STE20-related kinase adapter protein alpha/beta-like", "go_ids": ["GO:0043539"], "go_terms": ["GO:0043539:protein serine/threonine kinase activator activity:F"], "name": "STRAD_A/B-like", "pathway_ids": ["R-CEL-450302", "R-RNO-380972", "R-DDI-380972", "R-MMU-380972", "R-CEL-2559580", "R-HSA-380972", "R-BTA-380972"], "pathways": ["R-CEL-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK"], "type": "Family"}, "IPR047174": {"description": "Tyrosine-protein kinase BAZ1B", "go_ids": ["GO:0006338", "GO:0140801", "GO:0090535"], "go_terms": ["GO:0006338:chromatin remodeling:P", "GO:0140801:histone H2AXY142 kinase activity:F", "GO:0090535:WICH complex:C"], "name": "BAZ1B", "pathway_ids": ["R-MMU-5693565", "R-DRE-5693565", "R-MMU-5250924", "R-HSA-5693565", "R-DRE-5250924", "R-HSA-5250924"], "pathways": ["R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression"], "type": "Family"}, "IPR047175": {"description": "Spore coat protein S-like", "go_ids": [], "go_terms": [], "name": "CotS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047176": {"description": "FERM domain-containing protein 4A/B", "go_ids": ["GO:0090162"], "go_terms": ["GO:0090162:establishment of epithelial cell polarity:P"], "name": "FRMD4A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047177": {"description": "Peptidase M20A", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Pept_M20A", "pathway_ids": ["R-DRE-9673163", "R-HSA-9673163", "R-DDI-9673163", "R-XTR-9673163", "R-MMU-9673163", "R-SPO-9673163", "R-SCE-9673163"], "pathways": ["R-DRE-9673163:r:Oleoyl-phe metabolism", "R-HSA-9673163:r:Oleoyl-phe metabolism", "R-DDI-9673163:r:Oleoyl-phe metabolism", "R-XTR-9673163:r:Oleoyl-phe metabolism", "R-MMU-9673163:r:Oleoyl-phe metabolism", "R-SPO-9673163:r:Oleoyl-phe metabolism", "R-SCE-9673163:r:Oleoyl-phe metabolism"], "type": "Family"}, "IPR047178": {"description": "JNK-interacting protein 1", "go_ids": ["GO:0046328"], "go_terms": ["GO:0046328:regulation of JNK cascade:P"], "name": "JIP1_scaffold", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047180": {"description": "Hydrogenase maturation factor HoxX-like", "go_ids": [], "go_terms": [], "name": "HoxX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047181": {"description": "DCC-interacting protein 13-alpha/beta", "go_ids": [], "go_terms": [], "name": "DP13A/B", "pathway_ids": ["R-HSA-418889", "R-MMU-418889"], "pathways": ["R-HSA-418889:r:Caspase activation via Dependence Receptors in the absence of ligand", "R-MMU-418889:r:Caspase activation via Dependence Receptors in the absence of ligand"], "type": "Family"}, "IPR047182": {"description": "rRNA methyltransferase 1, mitochondrial", "go_ids": ["GO:0031167"], "go_terms": ["GO:0031167:rRNA methylation:P"], "name": "MRM1", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-6793080"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Family"}, "IPR047183": {"description": "Gentisate 1,2-dioxygenase-like", "go_ids": ["GO:0051213"], "go_terms": ["GO:0051213:dioxygenase activity:F"], "name": "GDO-like", "pathway_ids": ["PWY-7698", "PWY-6640", "PWY-6223", "PWY-7469"], "pathways": ["PWY-7698:t:2,5-xylenol and 3,5-xylenol degradation", "PWY-6640:t:salicylate degradation IV", "PWY-6223:t:gentisate degradation I", "PWY-7469:t:gentisate degradation II"], "type": "Family"}, "IPR047184": {"description": "KN motif and ankyrin repeat domain-containing protein 1-4", "go_ids": ["GO:0030837"], "go_terms": ["GO:0030837:negative regulation of actin filament polymerization:P"], "name": "KANK1-4", "pathway_ids": ["R-HSA-9018519", "R-HSA-9673768"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"], "type": "Family"}, "IPR047185": {"description": "Glutaredoxin-1", "go_ids": [], "go_terms": [], "name": "GLRX1", "pathway_ids": ["R-HSA-499943", "R-RNO-499943", "R-MMU-499943", "R-SSC-499943"], "pathways": ["R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates", "R-RNO-499943:r:Interconversion of nucleotide di- and triphosphates", "R-MMU-499943:r:Interconversion of nucleotide di- and triphosphates", "R-SSC-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR047194": {"description": "CwlT-like, lysozyme domain", "go_ids": [], "go_terms": [], "name": "CwlT-like_lysozyme", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047199": {"description": "Magnesium transporter CorA-like", "go_ids": [], "go_terms": [], "name": "CorA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047204": {"description": "RNase MRP protein 1, RNA binding domain", "go_ids": ["GO:0000172", "GO:0042134"], "go_terms": ["GO:0000172:ribonuclease MRP complex:C", "GO:0042134:rRNA primary transcript binding:F"], "name": "RMP1_RBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047205": {"description": "Ribonuclease MRP protein subunit RMP1", "go_ids": ["GO:0042134", "GO:0000172"], "go_terms": ["GO:0042134:rRNA primary transcript binding:F", "GO:0000172:ribonuclease MRP complex:C"], "name": "RMP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047208": {"description": "Forkhead box protein G1", "go_ids": ["GO:0043565", "GO:0006355"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "FOXG1", "pathway_ids": ["R-GGA-9617828", "R-RNO-9617828", "R-HSA-9022692", "R-DME-9617828", "R-HSA-9617828", "R-MMU-9617828"], "pathways": ["R-GGA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-RNO-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-DME-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-HSA-9617828:r:FOXO-mediated transcription of cell cycle genes", "R-MMU-9617828:r:FOXO-mediated transcription of cell cycle genes"], "type": "Family"}, "IPR047211": {"description": "Pyruvate oxidase/Pyruvate dehydrogenase [ubiquinone]-like", "go_ids": [], "go_terms": [], "name": "POXB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047216": {"description": "Putative endonuclease DUF559, bacteria", "go_ids": [], "go_terms": [], "name": "Endonuclease_DUF559_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047227": {"description": "RNA-binding protein MEX3", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "MEX3", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR047229": {"description": "Nuclear factor interleukin-3-regulated protein-like", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "NFIL3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047230": {"description": "Circadian locomoter output cycles protein kaput-like", "go_ids": ["GO:0000981", "GO:0032922"], "go_terms": ["GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific:F", "GO:0032922:circadian regulation of gene expression:P"], "name": "CLOCK-like", "pathway_ids": ["R-HSA-1989781", "R-DME-432524", "R-HSA-9931521", "R-HSA-9707616", "R-DME-432626", "R-HSA-1368108", "R-DME-432560", "R-HSA-9931510", "R-DME-432620", "R-HSA-9931512", "R-DME-432408", "R-DME-432395", "R-HSA-3214847", "R-HSA-9931529", "R-HSA-9931509", "R-DME-432501"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-432524:r:Degradation of PER", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-9707616:r:Heme signaling", "R-DME-432626:r:Circadian Clock pathway", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-DME-432560:r:Transcription activation by CLK:CYC and repression by VRI", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-DME-432620:r:Dephosphorylation of PER", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-DME-432408:r:Transcription regulation of cwo gene", "R-DME-432395:r:Degradation of TIM", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9931529:r:Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-DME-432501:r:Transcription repression by PER and activation by PDP1"], "type": "Family"}, "IPR047234": {"description": "GRAF family", "go_ids": ["GO:0005096"], "go_terms": ["GO:0005096:GTPase activator activity:F"], "name": "GRAF_fam", "pathway_ids": ["R-RNO-9013026", "R-XTR-9013106", "R-HSA-9013409", "R-HSA-9013405", "R-GGA-9013026", "R-RNO-9013409", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-XTR-9013026", "R-HSA-9013106", "R-BTA-9013148", "R-GGA-9013106", "R-DRE-9013404", "R-HSA-9013423", "R-DME-9013148", "R-GGA-9013409", "R-GGA-9013404", "R-HSA-9013148", "R-DME-9013409", "R-XTR-9013423", "R-DRE-9013149", "R-GGA-9013406", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-9013406", "R-RNO-9013106", "R-GGA-9013149", "R-XTR-9013409", "R-DME-9013149", "R-GGA-9013148", "R-DME-8980692", "R-DME-9013406", "R-RNO-9013148", "R-GGA-9013423", "R-XTR-9013148", "R-HSA-9013404", "R-MMU-9013423", "R-RNO-9013423", "R-HSA-9013149", "R-XTR-8980692", "R-DRE-9013148", "R-HSA-8980692", "R-HSA-211728", "R-XTR-9013404", "R-XTR-9013406", "R-GGA-8980692", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9013026", "R-BTA-8980692", "R-DRE-8980692", "R-HSA-9013406", "R-MMU-9013149", "R-DME-9013423", "R-DRE-9013423"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-XTR-9013106:r:RHOC GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-GGA-9013026:r:RHOB GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-XTR-9013026:r:RHOB GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-GGA-9013106:r:RHOC GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-GGA-9013409:r:RHOJ GTPase cycle", "R-GGA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-XTR-9013423:r:RAC3 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-GGA-9013406:r:RHOQ GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-GGA-9013149:r:RAC1 GTPase cycle", "R-XTR-9013409:r:RHOJ GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-GGA-9013148:r:CDC42 GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-GGA-9013423:r:RAC3 GTPase cycle", "R-XTR-9013148:r:CDC42 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-XTR-8980692:r:RHOA GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-211728:r:Regulation of PAK-2p34 activity by PS-GAP/RHG10", "R-XTR-9013404:r:RAC2 GTPase cycle", "R-XTR-9013406:r:RHOQ GTPase cycle", "R-GGA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR047242": {"description": "Pre-mRNA splicing factor component CDC5L/Cef1", "go_ids": ["GO:0000974", "GO:0000398"], "go_terms": ["GO:0000974:Prp19 complex:C", "GO:0000398:mRNA splicing, via spliceosome:P"], "name": "CDC5L/Cef1", "pathway_ids": ["R-HSA-72163", "R-RNO-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR047252": {"description": "TP53-binding protein 1-like", "go_ids": [], "go_terms": [], "name": "TP53BP1-like", "pathway_ids": ["R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-69473", "R-MMU-3232118", "R-HSA-3232118", "R-CEL-3232118", "R-HSA-5693565", "R-SCE-3232118", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-3232118:r:SUMOylation of transcription factors", "R-HSA-3232118:r:SUMOylation of transcription factors", "R-CEL-3232118:r:SUMOylation of transcription factors", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-3232118:r:SUMOylation of transcription factors", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Family"}, "IPR047259": {"description": "QUIRKY-like", "go_ids": [], "go_terms": [], "name": "QUIRKY-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047260": {"description": "ERCC1-like, central domain", "go_ids": [], "go_terms": [], "name": "ERCC1-like_central_dom", "pathway_ids": ["R-DDI-6782135", "R-DDI-5696395", "R-BTA-5685938", "R-MMU-6782135", "R-BTA-6782135", "R-HSA-6782135", "R-MMU-5685938", "R-HSA-6783310", "R-MMU-6783310", "R-MMU-5696395", "R-SPO-5696395", "R-SPO-5696400", "R-BTA-6783310", "R-HSA-5696395", "R-HSA-5696400", "R-BTA-5696395", "R-SPO-6782135", "R-BTA-5696400", "R-HSA-5685938", "R-MMU-5696400"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-BTA-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5696400:r:Dual Incision in GG-NER"], "type": "Domain"}, "IPR047262": {"description": "Peroxiredoxin-like 1", "go_ids": [], "go_terms": [], "name": "PRX-like1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047269": {"description": "Zinc finger MYND domain-containing protein 11", "go_ids": ["GO:0034243", "GO:0003714"], "go_terms": ["GO:0034243:regulation of transcription elongation by RNA polymerase II:P", "GO:0003714:transcription corepressor activity:F"], "name": "ZMY11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047271": {"description": "Ephexin-like", "go_ids": ["GO:0005085"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F"], "name": "Ephexin-like", "pathway_ids": ["R-HSA-193648", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-HSA-416482", "R-RNO-9013149", "R-RNO-3928663", "R-MMU-9013148", "R-HSA-9013106", "R-RNO-9013148", "R-MMU-3928663", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-3928663", "R-RNO-416482", "R-MMU-9013026", "R-MMU-416482", "R-HSA-9013148", "R-MMU-193648", "R-HSA-9013026", "R-HSA-9013408", "R-MMU-9013149", "R-RNO-193648"], "pathways": ["R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-193648:r:NRAGE signals death through JNK"], "type": "Family"}, "IPR047273": {"description": "Vertnin-like, ovarian tumor domain", "go_ids": [], "go_terms": [], "name": "VRTN_OTU_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047278": {"description": "DENN domain-containing protein 5A/B", "go_ids": ["GO:0005085", "GO:0031267"], "go_terms": ["GO:0005085:guanyl-nucleotide exchange factor activity:F", "GO:0031267:small GTPase binding:F"], "name": "DEN5A/B", "pathway_ids": ["R-RNO-8876198", "R-HSA-8876198", "R-MMU-8876198"], "pathways": ["R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR047296": {"description": "UvrC/Cho-like, GIY-YIG domain", "go_ids": ["GO:0006289"], "go_terms": ["GO:0006289:nucleotide-excision repair:P"], "name": "GIY-YIG_UvrC_Cho", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047325": {"description": "Cyclic nucleotide phosphodiesterase, catalytic domain", "go_ids": ["GO:0004113"], "go_terms": ["GO:0004113:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity:F"], "name": "CNPase_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047335": {"description": "RUN and FYVE domain-containing protein 1-3", "go_ids": [], "go_terms": [], "name": "RUFY1-3", "pathway_ids": ["R-HSA-1660499", "R-MMU-1660499"], "pathways": ["R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Family"}, "IPR047340": {"description": "RUN domain-containing protein 3A/B", "go_ids": [], "go_terms": [], "name": "RUNDC3A_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047343": {"description": "AP-4 complex accessory subunit RUSC1/2", "go_ids": [], "go_terms": [], "name": "RUSC1_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047365": {"description": "PTM/DIR17-like, Tudor domain", "go_ids": [], "go_terms": [], "name": "Tudor_AtPTM-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047417": {"description": "MUS81, winged helix domain", "go_ids": [], "go_terms": [], "name": "WHD_MUS81", "pathway_ids": ["R-DRE-5693568", "R-MMU-6783310", "R-XTR-5693568", "R-SCE-5693568", "R-SPO-5693568", "R-RNO-5693568", "R-MMU-5693568", "R-HSA-5693568", "R-HSA-6783310", "R-RNO-6783310", "R-DRE-6783310"], "pathways": ["R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-XTR-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SCE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-SPO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR047497": {"description": "Protein LURE 1.1-1.6, defensin-like domain", "go_ids": [], "go_terms": [], "name": "DEFL_AtLURE1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047513": {"description": "Forkhead box protein J1", "go_ids": ["GO:0006355", "GO:0003700"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P", "GO:0003700:DNA-binding transcription factor activity:F"], "name": "FOXJ1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047525": {"description": "DNA transformation protein TfoX-like", "go_ids": [], "go_terms": [], "name": "TfoX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047526": {"description": "Tumor necrosis factor receptor superfamily member 19/27/EDAR", "go_ids": ["GO:0043123", "GO:0038023", "GO:0046330"], "go_terms": ["GO:0043123:positive regulation of canonical NF-kappaB signal transduction:P", "GO:0038023:signaling receptor activity:F", "GO:0046330:positive regulation of JNK cascade:P"], "name": "TNR19/27/EDAR", "pathway_ids": ["R-HSA-5669034", "R-MMU-5669034"], "pathways": ["R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR047544": {"description": "E3 ubiquitin-protein ligase RNF216, RING finger, HC subclass", "go_ids": [], "go_terms": [], "name": "RING-HC_RBR_RNF216", "pathway_ids": ["R-HSA-936440"], "pathways": ["R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling"], "type": "Domain"}, "IPR047546": {"description": "E3 ubiquitin-protein ligase RNF216, Rcat domain", "go_ids": [], "go_terms": [], "name": "Rcat_RBR_RNF216", "pathway_ids": ["R-HSA-936440"], "pathways": ["R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling"], "type": "Domain"}, "IPR047549": {"description": "BICC1, first type I KH domain", "go_ids": [], "go_terms": [], "name": "BICC1_KH-I_rpt1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047565": {"description": "Alpha-macroglobulin-like, thiol-ester bond-forming region", "go_ids": [], "go_terms": [], "name": "Alpha-macroglob_thiol-ester_cl", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-MMU-163125", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-163125", "R-HSA-418594", "R-MMU-198933", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Conserved_site"}, "IPR047569": {"description": "Carbohydrate binding module family 56", "go_ids": ["GO:0030246"], "go_terms": ["GO:0030246:carbohydrate binding:F"], "name": "CBM56", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047587": {"description": "DNA-(apurinic or apyrimidinic site) endonuclease", "go_ids": ["GO:0003906", "GO:0099015"], "go_terms": ["GO:0003906:DNA-(apurinic or apyrimidinic site) endonuclease activity:F", "GO:0099015:degradation of host chromosome by virus:P"], "name": "APNUC_T5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047589": {"description": "DUF11 repeat", "go_ids": [], "go_terms": [], "name": "DUF11_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR047590": {"description": "Cell division protein FtsX, proteobacterial-type", "go_ids": ["GO:0051301"], "go_terms": ["GO:0051301:cell division:P"], "name": "FtsX_proteobact-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047592": {"description": "Probable 3-phenylpropionic acid transporter", "go_ids": [], "go_terms": [], "name": "HcaT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047600": {"description": "Internalin A", "go_ids": [], "go_terms": [], "name": "InlA", "pathway_ids": ["R-HSA-8876493"], "pathways": ["R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells"], "type": "Family"}, "IPR047601": {"description": "Deacetylase EF_0837-like", "go_ids": [], "go_terms": [], "name": "EF_0837-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047603": {"description": "FxsC, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FxsC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047610": {"description": "Translesion DNA synthesis-associated protein ImuA", "go_ids": [], "go_terms": [], "name": "ImuA_translesion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047611": {"description": "Plasmid replication protein RepC", "go_ids": [], "go_terms": [], "name": "RepABC_RepC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047620": {"description": "Peptidase M17, peptidase B-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "M17_PepB-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047621": {"description": "Ribosomal protein L36, bacteria", "go_ids": [], "go_terms": [], "name": "Ribosomal_L36_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047623": {"description": "Succinate-acetate/proton symporter SatP", "go_ids": [], "go_terms": [], "name": "SatP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047629": {"description": "IS1182 transposase", "go_ids": [], "go_terms": [], "name": "IS1182_transpos", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047634": {"description": "Acyl-CoA dehydrogenase FadE", "go_ids": ["GO:0003995"], "go_terms": ["GO:0003995:acyl-CoA dehydrogenase activity:F"], "name": "FadE", "pathway_ids": ["PWY-7094", "PWY-7654", "PWY-8354", "PWY-8181"], "pathways": ["PWY-7094:t:fatty acid salvage", "PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-8354:t:adipate degradation", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation"], "type": "Family"}, "IPR047640": {"description": "HTH-type transcriptional regulator RpiR-like", "go_ids": ["GO:0003700", "GO:0003677", "GO:0097367", "GO:0006355"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F", "GO:0003677:DNA binding:F", "GO:0097367:carbohydrate derivative binding:F", "GO:0006355:regulation of DNA-templated transcription:P"], "name": "RpiR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047641": {"description": "ABC transporter, ATP-binding protein MalK/UgpC-like", "go_ids": ["GO:0043190", "GO:0016887"], "go_terms": ["GO:0043190:ATP-binding cassette (ABC) transporter complex:C", "GO:0016887:ATP hydrolysis activity:F"], "name": "ABC_transpr_MalK/UgpC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047647": {"description": "ISAs1 transposase", "go_ids": [], "go_terms": [], "name": "ISAs1_transpos", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047650": {"description": "Transposase IS110-like", "go_ids": [], "go_terms": [], "name": "Transpos_IS110", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047651": {"description": "Ribosome-associated ATPase RbbA", "go_ids": [], "go_terms": [], "name": "ABC2_perm_RbbA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047653": {"description": "Tn3-like transposase", "go_ids": [], "go_terms": [], "name": "Tn3-like_transpos", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047654": {"description": "IS1634 transposase", "go_ids": [], "go_terms": [], "name": "IS1634_transpos", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047655": {"description": "Transposase IS630-like", "go_ids": [], "go_terms": [], "name": "Transpos_IS630-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047656": {"description": "IS481-like transposase", "go_ids": [], "go_terms": [], "name": "IS481-like_transpos", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047657": {"description": "Metalloprotease PmbA", "go_ids": [], "go_terms": [], "name": "PmbA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047658": {"description": "IS4-like transposase", "go_ids": [], "go_terms": [], "name": "IS4-like_transpos", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047659": {"description": "Type VII secretion system-associated protein", "go_ids": [], "go_terms": [], "name": "T7SS_assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047660": {"description": "DsrMKJOP redox complex, subunit DsrM", "go_ids": [], "go_terms": [], "name": "DsrM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047661": {"description": "Insertion sequence IS21-like ATPase IstB", "go_ids": [], "go_terms": [], "name": "IstB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047662": {"description": "SemiSWEET transporter", "go_ids": ["GO:0051119"], "go_terms": ["GO:0051119:sugar transmembrane transporter activity:F"], "name": "SemiSWEET", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047663": {"description": "Transcription antitermination protein LoaP", "go_ids": ["GO:0006355"], "go_terms": ["GO:0006355:regulation of DNA-templated transcription:P"], "name": "Transcription_antiterm_LoaP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047664": {"description": "Sugar transporter SWEET", "go_ids": ["GO:0051119"], "go_terms": ["GO:0051119:sugar transmembrane transporter activity:F"], "name": "SWEET", "pathway_ids": ["R-MMU-189200", "R-RNO-189200", "R-HSA-189200", "R-DRE-189200", "R-DDI-189200"], "pathways": ["R-MMU-189200:r:Cellular hexose transport", "R-RNO-189200:r:Cellular hexose transport", "R-HSA-189200:r:Cellular hexose transport", "R-DRE-189200:r:Cellular hexose transport", "R-DDI-189200:r:Cellular hexose transport"], "type": "Family"}, "IPR047665": {"description": "Competence protein ComGG, Streptococcus-type", "go_ids": [], "go_terms": [], "name": "ComGG_streptococcus-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047666": {"description": "ANR transcriptional regulator", "go_ids": [], "go_terms": [], "name": "ANR_neg_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047667": {"description": "Competence type IV pilus ATPase ComGA", "go_ids": [], "go_terms": [], "name": "ATPase_ComGA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047668": {"description": "DsrMKJOP redox complex, subunit DsrJ", "go_ids": [], "go_terms": [], "name": "DsrJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047669": {"description": "MtrAB system histidine kinase MtrB", "go_ids": ["GO:0004673"], "go_terms": ["GO:0004673:protein histidine kinase activity:F"], "name": "MtrAB_MtrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047670": {"description": "YfjT-like", "go_ids": [], "go_terms": [], "name": "YfjT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047671": {"description": "MtrAB system response regulator MtrA", "go_ids": ["GO:0045893", "GO:0000156", "GO:0000976"], "go_terms": ["GO:0045893:positive regulation of DNA-templated transcription:P", "GO:0000156:phosphorelay response regulator activity:F", "GO:0000976:transcription cis-regulatory region binding:F"], "name": "MtrAB_MtrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047672": {"description": "Cyclopropane mycolic acid synthase, actinobacteria", "go_ids": [], "go_terms": [], "name": "CMAS_actinobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047674": {"description": "CAL67264-like", "go_ids": [], "go_terms": [], "name": "CAL67264-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047675": {"description": "Putative zinc-binding domain", "go_ids": [], "go_terms": [], "name": "Putative_zinc-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047676": {"description": "FxLYD domain", "go_ids": [], "go_terms": [], "name": "FxLYD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047677": {"description": "GDCCVxC domain", "go_ids": [], "go_terms": [], "name": "GDCCVxC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047678": {"description": "Dehydratase YjiM-like", "go_ids": [], "go_terms": [], "name": "YjiM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047679": {"description": "Probable ATP-binding protein BrxC", "go_ids": [], "go_terms": [], "name": "BREX_BrxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047680": {"description": "Serine protease MarP-like", "go_ids": [], "go_terms": [], "name": "MarP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047681": {"description": "PPA1309-like", "go_ids": [], "go_terms": [], "name": "PPA1309-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047682": {"description": "Septation protein SepH-like", "go_ids": [], "go_terms": [], "name": "SepH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047684": {"description": "Iron uptake porin Som-like", "go_ids": [], "go_terms": [], "name": "Por_som-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047685": {"description": "Copper resistance protein CopC-like", "go_ids": [], "go_terms": [], "name": "CopC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047686": {"description": "Benzoate diol dehydrogenase BenD", "go_ids": [], "go_terms": [], "name": "BenD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047687": {"description": "4-oxalomesaconate tautomerase-like", "go_ids": [], "go_terms": [], "name": "OMA_tautomer-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047688": {"description": "DNA endonuclease SmrA", "go_ids": [], "go_terms": [], "name": "Endonuc_SmrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047689": {"description": "Copper resistance protein D", "go_ids": [], "go_terms": [], "name": "CopD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047690": {"description": "Uncharacterised protein family IPExxxVDY", "go_ids": [], "go_terms": [], "name": "IPExxxVDY_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047691": {"description": "GT4 family glycosyltransferase PelF-like", "go_ids": [], "go_terms": [], "name": "PelF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047692": {"description": "Competence type IV pilus assembly protein ComGB", "go_ids": [], "go_terms": [], "name": "T4P_ComGB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047693": {"description": "RNA-guided endonuclease IscB-like", "go_ids": [], "go_terms": [], "name": "RNA-guided_IscB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047694": {"description": "Lipid A hydroxylase LpxO-like", "go_ids": [], "go_terms": [], "name": "Lipid_A_LpxO-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047695": {"description": "Type IV secretion system, VirB10/PtlG", "go_ids": [], "go_terms": [], "name": "T4SS_VirB10/PtlG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047696": {"description": "Cell division inhibitor SulA, enterobacterial type", "go_ids": [], "go_terms": [], "name": "SulA_enterobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047697": {"description": "Zinc metallochaperone AztD-like", "go_ids": [], "go_terms": [], "name": "AztD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047698": {"description": "Nitroreductase subunit ArsF-like", "go_ids": [], "go_terms": [], "name": "ArsF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047699": {"description": "Transporter permease, putative, prefix domain", "go_ids": [], "go_terms": [], "name": "Permease_put_prefix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047700": {"description": "Nitrate/nitrite transporter NrtS-like", "go_ids": [], "go_terms": [], "name": "NrtS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047701": {"description": "Zinc ABC transporter, substrate-binding protein AztC-like", "go_ids": [], "go_terms": [], "name": "AztC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047702": {"description": "VgrG-related", "go_ids": [], "go_terms": [], "name": "VgrG-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047703": {"description": "SCO2322-like domain", "go_ids": [], "go_terms": [], "name": "SCO2322-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047704": {"description": "GPS-CTERM domain", "go_ids": [], "go_terms": [], "name": "GPS-CTERM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047705": {"description": "AimR transcriptional regulator-like", "go_ids": [], "go_terms": [], "name": "AimR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047706": {"description": "BCAM0308-like", "go_ids": [], "go_terms": [], "name": "BCAM0308-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047707": {"description": "Phenolic acid decarboxylase VdcD-like", "go_ids": [], "go_terms": [], "name": "VdcD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047708": {"description": "CD1871A-like", "go_ids": [], "go_terms": [], "name": "CD1871A-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047709": {"description": "HpsJ-like", "go_ids": [], "go_terms": [], "name": "HpsJ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047710": {"description": "IS5-like transposase", "go_ids": [], "go_terms": [], "name": "Transpos_IS5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047711": {"description": "Conjugated bile acid hydrolase", "go_ids": [], "go_terms": [], "name": "CBAH", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-8453", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-8293", "PWY-8431", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-6899", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-7652", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7771", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8229", "PWY-7571", "PWY-8374", "PWY-7850", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7496", "PWY-7354", "PWY-8432", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-1822", "PWY-7465", "PWY-84", "PWY-6409", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-5784", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-7430", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8135", "PWY-8418", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-8402", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7403", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-7018", "PWY-5497", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-8453:t:D-glutamate degradation", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-8293:t:alazopeptin biosynthesis", "PWY-8431:t:L-mimosine degradation", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-6899:t:base-degraded thiamine salvage", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-7652:t:echinocandin B degradation", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8229:t:UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-7850:t:taurine biosynthesis II", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7496:t:linuron degradation", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-1822:t:indole-3-acetate activation I", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8135:t:bile acids deconjugation", "PWY-8418:t:S-benzyl-L-cysteine degradation", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7403:t:tetramethylpyrazine degradation", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR047712": {"description": "FAD-dependent urate hydroxylase", "go_ids": ["GO:0071949", "GO:0004846", "GO:0019628"], "go_terms": ["GO:0071949:FAD binding:F", "GO:0004846:urate oxidase activity:F", "GO:0019628:urate catabolic process:P"], "name": "HpxO", "pathway_ids": ["PWY-7394"], "pathways": ["PWY-7394:t:urate conversion to allantoin II"], "type": "Family"}, "IPR047713": {"description": "Uncharacterised cupin fold protein DHCW", "go_ids": [], "go_terms": [], "name": "DHCW_cupin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047714": {"description": "Mks condensin complex protein MksF, putative", "go_ids": [], "go_terms": [], "name": "MksF_put-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047715": {"description": "EboA domain", "go_ids": [], "go_terms": [], "name": "EboA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047716": {"description": "Metabolite traffic protein EboA", "go_ids": [], "go_terms": [], "name": "EboA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047717": {"description": "CC-star protein", "go_ids": [], "go_terms": [], "name": "CC_star_Cory", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047718": {"description": "Anti-sigma factor RsbA-like", "go_ids": [], "go_terms": [], "name": "RsbA-like_anti_sig", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047719": {"description": "SCO5918-like", "go_ids": [], "go_terms": [], "name": "SCO5918-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047720": {"description": "Mks condensin complex protein MksB, putative", "go_ids": [], "go_terms": [], "name": "MksB_put-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047721": {"description": "DISARM protein DrmB", "go_ids": [], "go_terms": [], "name": "DrmB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047722": {"description": "Uncharacterised protein STM4015-like", "go_ids": [], "go_terms": [], "name": "STM4015-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047723": {"description": "Mks condensin complex protein MksE, pseudomonadaceae", "go_ids": [], "go_terms": [], "name": "MksE_pseudomon-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047724": {"description": "Streptophobe SCO7274-like", "go_ids": [], "go_terms": [], "name": "Streptophobe", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047725": {"description": "Transcriptional regulator AlgP, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AlgP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047726": {"description": "Chaperone CsgH domain", "go_ids": [], "go_terms": [], "name": "CsgH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047727": {"description": "Uncharacterised protein Sce7725-like", "go_ids": [], "go_terms": [], "name": "Sce7725-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047728": {"description": "Lipid droplet-associated protein", "go_ids": [], "go_terms": [], "name": "LipDrop-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047729": {"description": "Sce7726-like", "go_ids": [], "go_terms": [], "name": "Sce7726-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047730": {"description": "ABZJ_00895-like", "go_ids": [], "go_terms": [], "name": "ABZJ_00895-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047731": {"description": "Zinc beta-ribbon finger, putative", "go_ids": [], "go_terms": [], "name": "Zinc_ribbon_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047732": {"description": "Inner membrane protein YedE-like", "go_ids": [], "go_terms": [], "name": "YedE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047733": {"description": "Thiosulfate transporter TsuA", "go_ids": [], "go_terms": [], "name": "TsuA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047735": {"description": "GrdX-like", "go_ids": [], "go_terms": [], "name": "GrdX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047736": {"description": "Rodlin protein RdlA/B-like", "go_ids": [], "go_terms": [], "name": "RdlA/B-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047737": {"description": "Rz1-like lysis system protein LysC", "go_ids": [], "go_terms": [], "name": "LysC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047738": {"description": "SAV_2336-like, N-terminal", "go_ids": [], "go_terms": [], "name": "SAV_2336-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047739": {"description": "Growth-regulating ATPase SCO5717-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SCO5717-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047740": {"description": "SMEK domain", "go_ids": [], "go_terms": [], "name": "SMEK_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047741": {"description": "Uncharacterised protein DIP1984-like", "go_ids": [], "go_terms": [], "name": "DIP1984-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047742": {"description": "Uncharacterised protein PA4642-like", "go_ids": [], "go_terms": [], "name": "PA4642-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047743": {"description": "Membrane protein YnhF-like", "go_ids": [], "go_terms": [], "name": "YnhF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047744": {"description": "Membrane protein YmiA, putative-like", "go_ids": [], "go_terms": [], "name": "YmiA_put-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047745": {"description": "Autotransporter-associated protein SinI-like", "go_ids": [], "go_terms": [], "name": "SinI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047746": {"description": "Cell wall amidase Dae2/Tae2-like", "go_ids": [], "go_terms": [], "name": "Dae2/Tae2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047748": {"description": "Zinc ABC transporter ATP-binding protein AztA-like", "go_ids": [], "go_terms": [], "name": "AztA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047749": {"description": "Pathogenicity island replication protein STY4528-like", "go_ids": [], "go_terms": [], "name": "STY4528-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047750": {"description": "Uncharacterized protein YdjY-like", "go_ids": [], "go_terms": [], "name": "YdjY-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047751": {"description": "Plasmid mobilization protein MobA-like", "go_ids": [], "go_terms": [], "name": "MobA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047752": {"description": "PBP2a activator MacP", "go_ids": [], "go_terms": [], "name": "MacP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047753": {"description": "Membrane protein YtzI-like", "go_ids": [], "go_terms": [], "name": "YtzI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047754": {"description": "T3SS inner rod subunit SctI-like", "go_ids": [], "go_terms": [], "name": "T3SS_SctI-like", "pathway_ids": ["R-HSA-844623"], "pathways": ["R-HSA-844623:r:The IPAF inflammasome"], "type": "Family"}, "IPR047755": {"description": "AKP thiolase subunit OrtA", "go_ids": [], "go_terms": [], "name": "OrtA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047756": {"description": "IcmT-like", "go_ids": [], "go_terms": [], "name": "IcmT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047757": {"description": "Gamma-butyrolactone biosynthesis protein AfsA-like", "go_ids": ["GO:0016740"], "go_terms": ["GO:0016740:transferase activity:F"], "name": "AfsA-like", "pathway_ids": ["PWY-7882", "PWY-7881", "PWY-7878"], "pathways": ["PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis"], "type": "Family"}, "IPR047758": {"description": "Di-heme-cytochrome C peroxidase", "go_ids": [], "go_terms": [], "name": "CytoC_perox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047759": {"description": "Antiholin LysA-like", "go_ids": [], "go_terms": [], "name": "LysA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047760": {"description": "XaxAB toxin subunit B-like", "go_ids": [], "go_terms": [], "name": "XaxB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047761": {"description": "NadS-like", "go_ids": [], "go_terms": [], "name": "NadS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047762": {"description": "EHMT1/2, cysteine-rich region", "go_ids": ["GO:0008270"], "go_terms": ["GO:0008270:zinc ion binding:F"], "name": "EHMT_CRR", "pathway_ids": ["R-HSA-9843970", "R-HSA-6804760", "R-HSA-427389", "R-MMU-2559582", "R-HSA-73762", "R-HSA-2559582", "R-HSA-8953750", "PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-8853884", "R-MMU-6804760", "R-MMU-8953750", "R-MMU-73762", "R-MMU-3214841", "R-HSA-3214841"], "pathways": ["R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines"], "type": "Domain"}, "IPR047763": {"description": "Peptidoglycan-binding domain, phiBT1-type", "go_ids": [], "go_terms": [], "name": "PG_bind_dom_phiBT1-type", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047764": {"description": "Cortex morphogenetic protein CmpA", "go_ids": [], "go_terms": [], "name": "CmpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047765": {"description": "GHMP kinase GYDIA-like", "go_ids": [], "go_terms": [], "name": "GHMP_GYDIA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047766": {"description": "Uncharacterised protein family PxxKW", "go_ids": [], "go_terms": [], "name": "PxxKW_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047767": {"description": "PSP1-like", "go_ids": [], "go_terms": [], "name": "PSP1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047768": {"description": "Transposase for transposon Tn5-like", "go_ids": [], "go_terms": [], "name": "Tn5p-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047769": {"description": "Organoarsenical effux MFS transporter ArsJ", "go_ids": [], "go_terms": [], "name": "MFS_ArsJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047770": {"description": "Sensor histidine kinase RegB", "go_ids": ["GO:0000155"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F"], "name": "RegB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047771": {"description": "Radical SAM STM4011-like", "go_ids": [], "go_terms": [], "name": "Radical_SAM_STM4011-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047772": {"description": "ActR/PrrA/RegA redox response regulator transcription factor", "go_ids": ["GO:0000160"], "go_terms": ["GO:0000160:phosphorelay signal transduction system:P"], "name": "ActR_PrrA_rreg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047773": {"description": "YHYH domain, bacterial", "go_ids": [], "go_terms": [], "name": "YHYH_dom_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047774": {"description": "Virulence factor SrfA-like", "go_ids": [], "go_terms": [], "name": "SrfA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047775": {"description": "Peroxide/acid stress response protein YhcN-like", "go_ids": [], "go_terms": [], "name": "Stress_YhcN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047776": {"description": "Tryptophan ABC transporter substrate-binding TrpX-like", "go_ids": [], "go_terms": [], "name": "ABC_SBP_TrpX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047777": {"description": "LapA-like, retention module", "go_ids": [], "go_terms": [], "name": "LapA-like_RM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047778": {"description": "Uncharacterised protein STM4014-like", "go_ids": [], "go_terms": [], "name": "STM4014-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047779": {"description": "Putative aga operon transcriptional repressor-like", "go_ids": [], "go_terms": [], "name": "AgaR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047780": {"description": "T6SS-associated TssQ-like", "go_ids": [], "go_terms": [], "name": "TssQ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047781": {"description": "Nickel-binding protein Mua", "go_ids": [], "go_terms": [], "name": "Mua", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047782": {"description": "Manganase accumulation protein MntS", "go_ids": [], "go_terms": [], "name": "MntS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047783": {"description": "ORF2/OrfX-like", "go_ids": [], "go_terms": [], "name": "ORF2/OrfX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047784": {"description": "TrgA", "go_ids": [], "go_terms": [], "name": "TrgA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047785": {"description": "tRNA mnm(5)s(2)U biosynthesis bifunctional protein MnmC, N-terminal", "go_ids": ["GO:0004808"], "go_terms": ["GO:0004808:tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity:F"], "name": "tRNA_MNMC2", "pathway_ids": ["PWY-7892"], "pathways": ["PWY-7892:t:tRNA-uridine 2-thiolation and selenation (bacteria)"], "type": "Domain"}, "IPR047786": {"description": "Fimbria major subunit Mfa1", "go_ids": ["GO:0009418"], "go_terms": ["GO:0009418:pilus shaft:C"], "name": "Mfa1_fim", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047787": {"description": "Phosphoethanolamine transferase EptC/CptA", "go_ids": [], "go_terms": [], "name": "EptC/CptA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047788": {"description": "Selenium metabolism-associated LysR-like transcriptional regulator", "go_ids": [], "go_terms": [], "name": "LysR-like_Sec_metab", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047789": {"description": "CU044_5270-like", "go_ids": [], "go_terms": [], "name": "CU044_5270-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047790": {"description": "Major capsid protein, shiphovirus-type", "go_ids": [], "go_terms": [], "name": "MCP_Sipho", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047791": {"description": "Transcriptional regulatory protein WalR", "go_ids": ["GO:0006633", "GO:0006355", "GO:0000976"], "go_terms": ["GO:0006633:fatty acid biosynthetic process:P", "GO:0006355:regulation of DNA-templated transcription:P", "GO:0000976:transcription cis-regulatory region binding:F"], "name": "WalR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047792": {"description": "Surface protein Hvo_1808-like", "go_ids": [], "go_terms": [], "name": "Hvo_1808-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047793": {"description": "Cell wall-active antibiotic response protein LiaF, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LiaF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047794": {"description": "Peptidase C45-like", "go_ids": [], "go_terms": [], "name": "C45_proenzyme-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047795": {"description": "Putative cytokinetic ring protein SteA-like", "go_ids": [], "go_terms": [], "name": "Put_SteA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047796": {"description": "Transcriptional repressor SdpR-like", "go_ids": [], "go_terms": [], "name": "SdpR-like_repress", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047797": {"description": "ISNCY transposase", "go_ids": [], "go_terms": [], "name": "ISNCY_transpos", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047798": {"description": "Integral membrane protein BPSS1780-like", "go_ids": [], "go_terms": [], "name": "BPSS1780-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047799": {"description": "Type IX secretion system, outer membrane channel protein PorV", "go_ids": [], "go_terms": [], "name": "T9SS_OM_PorV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047800": {"description": "SWFGD domain", "go_ids": [], "go_terms": [], "name": "SWFGD_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047801": {"description": "Peptidase C45", "go_ids": [], "go_terms": [], "name": "Peptidase_C45", "pathway_ids": ["PWY-5630"], "pathways": ["PWY-5630:t:penicillin K biosynthesis"], "type": "Family"}, "IPR047802": {"description": "Protein phosphatase CheZ", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "CheZ_Pase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047803": {"description": "DCD1A/B-like", "go_ids": [], "go_terms": [], "name": "DCD1A/B-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047804": {"description": "Peptidase C69, dipeptidase A-like", "go_ids": [], "go_terms": [], "name": "C69_dipept_A-like", "pathway_ids": ["PWY-8355", "PWY-8397", "PWY-7533"], "pathways": ["PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-7533:t:gliotoxin biosynthesis"], "type": "Family"}, "IPR047805": {"description": "Cyclic GMP-AMP synthase", "go_ids": ["GO:0140701"], "go_terms": ["GO:0140701:3',3'-cyclic GMP-AMP synthase activity:F"], "name": "GAMP_synthase", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Family"}, "IPR047806": {"description": "Integration host factor, actinobacterial-type", "go_ids": [], "go_terms": [], "name": "IHF_actinobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047807": {"description": "Lipoprotein YgdI/YgdR-like, Sm-like domain", "go_ids": [], "go_terms": [], "name": "YgdI/YgdR-like_Sm-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR047808": {"description": "Periplasmic metallochaperone CueP-like", "go_ids": [], "go_terms": [], "name": "CueP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047809": {"description": "Ubiquinone biosynthesis protein Coq7, proteobacteria", "go_ids": [], "go_terms": [], "name": "COQ7_proteobact", "pathway_ids": ["PWY-5870", "PWY-5873", "PWY-5871", "PWY-5856", "PWY-6708", "PWY-5857", "PWY-7230", "PWY-5872", "PWY-5855"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)"], "type": "Family"}, "IPR047810": {"description": "Heterocyst frequency control protein PatD-like", "go_ids": [], "go_terms": [], "name": "PatD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047811": {"description": "Putative cytochrome C oxidase assembly protein", "go_ids": [], "go_terms": [], "name": "CytC_ox_assmbl_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047812": {"description": "Small membrane protein YshB", "go_ids": [], "go_terms": [], "name": "YshB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047813": {"description": "Pilus motility taxis protein HmpF", "go_ids": [], "go_terms": [], "name": "HmpF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047814": {"description": "TfpX/TfpZ-like, type IV pilin accessory protein", "go_ids": [], "go_terms": [], "name": "TfpX/TfpZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047816": {"description": "Membrane protein SCO1431-like", "go_ids": [], "go_terms": [], "name": "SCO1431-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047818": {"description": "Inorganic phosphate transporter PitA/PitB", "go_ids": ["GO:0006817", "GO:0016020", "GO:0005315"], "go_terms": ["GO:0006817:phosphate ion transport:P", "GO:0016020:membrane:C", "GO:0005315:phosphate transmembrane transporter activity:F"], "name": "Phos_trans_PitA_PitB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047819": {"description": "P5B-type ATPase, N-terminal", "go_ids": [], "go_terms": [], "name": "P5A-ATPase_N", "pathway_ids": ["R-SPO-936837", "R-HSA-936837", "R-MMU-936837", "R-CEL-936837", "R-SCE-936837"], "pathways": ["R-SPO-936837:r:Ion transport by P-type ATPases", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-SCE-936837:r:Ion transport by P-type ATPases"], "type": "Domain"}, "IPR047830": {"description": "Quinohemoprotein amine dehydrogenase subunit gamma", "go_ids": [], "go_terms": [], "name": "QHNDH_gamma", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047831": {"description": "GPR180/TMEM145", "go_ids": [], "go_terms": [], "name": "GPR180/TMEM145", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047835": {"description": "PTS N-acetylgalactosamine transporter subunit IIC, AgaW-like", "go_ids": [], "go_terms": [], "name": "PTS_IIC_GalNAc_AgaW-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047838": {"description": "STM4013-like hydrolase", "go_ids": [], "go_terms": [], "name": "STM4013-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047839": {"description": "Small membrane protein YoaK", "go_ids": [], "go_terms": [], "name": "YoaK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047840": {"description": "SP_0191-like", "go_ids": [], "go_terms": [], "name": "SP_0191-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047841": {"description": "Reactive chlorine resistance periplasmic protein RclB", "go_ids": [], "go_terms": [], "name": "RclB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047842": {"description": "YdaE-like", "go_ids": [], "go_terms": [], "name": "YdaE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR047843": {"description": "Wntless-like, transmembrane domain", "go_ids": [], "go_terms": [], "name": "WLS-like_TM", "pathway_ids": ["R-RNO-3238698", "R-MMU-3238698", 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{"description": "Small membrane protein PA2485-like", "go_ids": [], "go_terms": [], "name": "PA2485-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048080": {"description": "Transcriptional regulator SutA", "go_ids": [], "go_terms": [], "name": "SutA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048081": {"description": "Type III secretion system co-regulatory protein PtrC-like", "go_ids": [], "go_terms": [], "name": "T3SS_coreg_PtrC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048082": {"description": "ParC-like", "go_ids": [], "go_terms": [], "name": "ParC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048083": {"description": "GrdB-related", "go_ids": [], "go_terms": [], "name": "GrdB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048084": {"description": "YniD-like", "go_ids": [], "go_terms": [], "name": "YniD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048085": 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[], "name": "CSP_N_ext_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048091": {"description": "Glutamine synthetase GlnII", "go_ids": ["GO:0004356"], "go_terms": ["GO:0004356:glutamine synthetase activity:F"], "name": "Gln_syn_GlnII", "pathway_ids": ["PWY-6964", "PWY-8294", "PWY-8291", "PWY-6963"], "pathways": ["PWY-6964:t:ammonia assimilation cycle II", "PWY-8294:t:L-aspartate degradation III (anaerobic)", "PWY-8291:t:L-aspartate degradation II (aerobic)", "PWY-6963:t:ammonia assimilation cycle I"], "type": "Family"}, "IPR048092": {"description": "Diguanylate cyclase DgcA", "go_ids": ["GO:0052621"], "go_terms": ["GO:0052621:diguanylate cyclase activity:F"], "name": "Dguan_cyc_DgcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048093": {"description": "MobT relaxase", "go_ids": [], "go_terms": [], "name": "MobT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048094": {"description": "YghX hydrolase-like", "go_ids": [], "go_terms": [], "name": "YghX_hydrolase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048095": {"description": "Dimethylamine corrinoid protein MtbC", "go_ids": [], "go_terms": [], "name": "Dimeth_corrin_MtbC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048096": {"description": "Methylcobamide:CoM methyltransferase MtbA", "go_ids": ["GO:0043791"], "go_terms": ["GO:0043791:dimethylamine methyltransferase activity:F"], "name": "Methylcob_mtaseMtbA", "pathway_ids": ["PWY-5248", "PWY-5247", "PWY-5250"], "pathways": ["PWY-5248:t:methanogenesis from dimethylamine", "PWY-5247:t:methanogenesis from methylamine", "PWY-5250:t:methanogenesis from trimethylamine"], "type": "Family"}, "IPR048097": {"description": "Cps14G polysaccharide biosynthesis glycosyltransferase-like domain", "go_ids": [], "go_terms": [], "name": "Cps14G-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048098": {"description": "MobB relaxase", "go_ids": [], "go_terms": [], "name": "MobB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048099": {"description": "Esterase EstA/EstP", "go_ids": [], "go_terms": [], "name": "Esterase_EstP/EstA", "pathway_ids": ["PWY-8454", "PWY-6857", "PWY-6303"], "pathways": ["PWY-8454:t:aspartame degradation", "PWY-6857:t:retinol biosynthesis", "PWY-6303:t:methyl indole-3-acetate interconversion"], "type": "Family"}, "IPR048100": {"description": "Exo-alpha-(1->6)-L-arabinopyranosidase", "go_ids": ["GO:0005975", "GO:0004553"], "go_terms": ["GO:0005975:carbohydrate metabolic process:P", "GO:0004553:hydrolase activity, hydrolyzing O-glycosyl compounds:F"], "name": "Alph_arabinopyran", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048101": {"description": "MobP2 relaxase", "go_ids": [], "go_terms": [], "name": "MobP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048102": {"description": "MobP3 relaxase", "go_ids": [], "go_terms": [], "name": "MobP3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048103": {"description": "Exoglucanase CbhB", "go_ids": ["GO:0016162", "GO:0030245"], "go_terms": ["GO:0016162:cellulose 1,4-beta-cellobiosidase activity:F", "GO:0030245:cellulose catabolic process:P"], "name": "Exoglucan_CbhB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048104": {"description": "FGLLP motif-containing membrane domain", "go_ids": [], "go_terms": [], "name": "Cola_memb_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048105": {"description": "Iron-sulfur cluster repair protein DnrN", "go_ids": ["GO:0006979", "GO:0030091", "GO:0046872"], "go_terms": ["GO:0006979:response to oxidative stress:P", "GO:0030091:protein repair:P", "GO:0046872:metal ion binding:F"], "name": "FeS_repair_DnrN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048106": {"description": "Sigma-54 dependent transcriptional regulator PrdR-like", "go_ids": [], "go_terms": [], "name": "PrdR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048107": {"description": "YgjJ-like", "go_ids": [], "go_terms": [], "name": "YgjJ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048108": {"description": "CBO2463/CBO2479 domain", "go_ids": [], "go_terms": [], "name": "CBO2463_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048109": {"description": "Ferredoxin, 2Fe-2S, Clostridium-type", "go_ids": [], "go_terms": [], "name": "Fdxn_Clost-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048110": {"description": "SA1362/YqhP-like", "go_ids": [], "go_terms": [], "name": "SA1362/YqhP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048111": {"description": "Ferredoxin 2Fe-2S, Azotobacter-type", "go_ids": [], "go_terms": [], "name": "Fdxn_Azotob-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048112": {"description": "Iron oxidase", "go_ids": ["GO:0009055", "GO:0019646"], "go_terms": ["GO:0009055:electron transfer activity:F", "GO:0019646:aerobic electron transport chain:P"], "name": "Feoxidase_Iro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048113": {"description": "Flagellum-secreted protein A", "go_ids": [], "go_terms": [], "name": "FspA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048114": {"description": "Type II secretion system protein GspC-like, Synergistales", "go_ids": [], "go_terms": [], "name": "T2SS_C_SYNERG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048115": {"description": "Type II secretion system protein GspL-like, Synergistales", "go_ids": [], "go_terms": [], "name": "T2SS_GspL_synerg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048116": {"description": "Type II secretion system protein GspM-like, Synergistales", "go_ids": [], "go_terms": [], "name": "T2SS_GspM_synerg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048117": {"description": "Type II secretion system protein GspN-like, Synergistales", "go_ids": [], "go_terms": [], "name": "T2SS_GspN_synerg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048118": {"description": "Anti-phage protein KwaA", "go_ids": [], "go_terms": [], "name": "KwaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048119": {"description": "Anti-phage protein KwaB", "go_ids": [], "go_terms": [], "name": "KwaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048120": {"description": "Site-specific integrase-like", "go_ids": [], "go_terms": [], "name": "Integrase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048121": {"description": "Tannase subtype A", "go_ids": [], "go_terms": [], "name": "Tannase_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048122": {"description": "O-unit flippase WZX-like", "go_ids": [], "go_terms": [], "name": "WZX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048123": {"description": "Na(+),Li(+),K(+)/H(+) antiporter subunit UmpB", "go_ids": ["GO:0006813", "GO:0006814", "GO:0015297"], "go_terms": ["GO:0006813:potassium ion transport:P", "GO:0006814:sodium ion transport:P", "GO:0015297:antiporter activity:F"], "name": "NaLiK_antip_UmpB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048124": {"description": "Tannase subtype B", "go_ids": [], "go_terms": [], "name": "Tannase_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048125": {"description": "Cyclic-di-AMP-binding protein CbpB", "go_ids": [], "go_terms": [], "name": "CBS_CbpB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048126": {"description": "Toxin VasX", "go_ids": [], "go_terms": [], "name": "Toxin_VasX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048127": {"description": "Bacteriocin 51 precursor BacA", "go_ids": [], "go_terms": [], "name": "BacA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048128": {"description": "Isoafricanol/pristinol synthase", "go_ids": [], "go_terms": [], "name": "Isoafr/prist_syn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048129": {"description": "HrpD6, lysobacterales", "go_ids": [], "go_terms": [], "name": "HrpD6_lystobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048130": {"description": "Type VI secretion system effector ExIF-like", "go_ids": [], "go_terms": [], "name": "T6SS_ExIF-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048131": {"description": "HAEPLYID-like", "go_ids": [], "go_terms": [], "name": "HAEPLYID-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048132": {"description": "KHG/KDPG aldolase/sugar kinase fusion protein", "go_ids": [], "go_terms": [], "name": "Trifunc_aldol", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048133": {"description": "Alkane oxidation protein activator PraA/PraB-like", "go_ids": [], "go_terms": [], "name": "PraA/PraB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048134": {"description": "MXAN_5187-like", "go_ids": [], "go_terms": [], "name": "MXAN_5187-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048135": {"description": "Virulence-associated protein D-like", "go_ids": [], "go_terms": [], "name": "VapD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048136": {"description": "STM3941-like", "go_ids": [], "go_terms": [], "name": "STM3941-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048137": {"description": "HrpE-like", "go_ids": [], "go_terms": [], "name": "HrpE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048138": {"description": "(-)-alpha-amorphene synthase", "go_ids": [], "go_terms": [], "name": "Amorph_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048139": {"description": "CiaI campylobacter virulence factor", "go_ids": [], "go_terms": [], "name": "CiaI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048140": {"description": "Phosphoribosylformylglycinamidine synthase-associated small membrane protein", "go_ids": [], "go_terms": [], "name": "FGAM_small_mem", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048141": {"description": "7-epi-alpha-eudesmol synthase", "go_ids": [], "go_terms": [], "name": "Eudesmol_syn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048142": {"description": "RRQRL motif-containing zinc-binding protein", "go_ids": [], "go_terms": [], "name": "QRL_CxxC_CxxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048143": {"description": "Selina-4(15),7(11)-diene synthase", "go_ids": [], "go_terms": [], "name": "Selin_dien_syn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048144": {"description": "YicS", "go_ids": [], "go_terms": [], "name": "YicS_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048145": {"description": "1,4-alpha-glucan branching enzyme TTHA1902", "go_ids": [], "go_terms": [], "name": "TTHA1902", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048146": {"description": "RAxF-45-like", "go_ids": [], "go_terms": [], "name": "RAxF_45-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048147": {"description": "CBO0543-like", "go_ids": [], "go_terms": [], "name": "CBO0543-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048148": {"description": "PA4780 RIO1-like protein kinase", "go_ids": [], "go_terms": [], "name": "Prot_kin_PA4780", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048149": {"description": "YjaA", "go_ids": [], "go_terms": [], "name": "YjaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048150": {"description": "Spore coat protein CotA-like", "go_ids": [], "go_terms": [], "name": "Spore_exo_CotA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048151": {"description": "Ribosomal RNA small subunit methyltransferase F", "go_ids": [], "go_terms": [], "name": "RsmF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048152": {"description": "AMED_5909-like", "go_ids": [], "go_terms": [], "name": "AMED_5909-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048153": {"description": "Neutral ceramidase, Mycobacterium", "go_ids": [], "go_terms": [], "name": "Ceramidase_neut_Mycobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048154": {"description": "PA2816-like", "go_ids": [], "go_terms": [], "name": "PA2816-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048155": {"description": "Nodulation protein NodU", "go_ids": [], "go_terms": [], "name": "Nodul_NodU", "pathway_ids": ["PWY-8344", "PWY-7694", "PWY-7693", "PWY-8039", "PWY-5"], "pathways": ["PWY-8344:t:ansamitocin P biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-5:t:canavanine biosynthesis"], "type": "Family"}, "IPR048156": {"description": "PA2817-like", "go_ids": [], "go_terms": [], "name": "PA2817-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048157": {"description": "Nudix hydrolase DR_1025-like", "go_ids": ["GO:0016787"], "go_terms": ["GO:0016787:hydrolase activity:F"], "name": "Nud_hyd_Dein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048158": {"description": "Formate dehydrogenase, actinomycetes", "go_ids": [], "go_terms": [], "name": "Formate_DH_Act", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048159": {"description": "Acyltransferase PE", "go_ids": [], "go_terms": [], "name": "Acyl_transf_PE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048160": {"description": "Prenyl-diphosphate phosphatase", "go_ids": [], "go_terms": [], "name": "Prenyl-diphosphate_PPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048161": {"description": "PA2928-like", "go_ids": [], "go_terms": [], "name": "PA2928-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048162": {"description": "O-GlcNAcase BT_4395-like", "go_ids": [], "go_terms": [], "name": "O-GlcNAcase_BT_4395-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048163": {"description": "MM0924-like", "go_ids": [], "go_terms": [], "name": "MM0924_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048164": {"description": "YjdP", "go_ids": [], "go_terms": [], "name": "YjdP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048165": {"description": "Bluetail putative surface-anchoring domain", "go_ids": [], "go_terms": [], "name": "Bluetail_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048166": {"description": "VVA0879-like", "go_ids": [], "go_terms": [], "name": "VVA0879-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048167": {"description": "AQJ64_40280-like", "go_ids": [], "go_terms": [], "name": "AQJ64_40280-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048169": {"description": "DNA damage-induced SOS-independent cell division inhibitor A-like", "go_ids": [], "go_terms": [], "name": "DidA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048170": {"description": "DNA damage-induced cell division inhibitor SosA-like", "go_ids": [], "go_terms": [], "name": "SosA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048171": {"description": "Cell division-associated protein YmgF", "go_ids": ["GO:0051301"], "go_terms": ["GO:0051301:cell division:P"], "name": "YmgF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048172": {"description": "Serine endopeptidase HhoA/HhoB/HtrA-like", "go_ids": [], "go_terms": [], "name": "HhoA_HhoB_HtrA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048173": {"description": "Sll0314-like", "go_ids": [], "go_terms": [], "name": "Sll0314-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048174": {"description": "O-antigen biosynthesis glycosyltransferase WbnI-like", "go_ids": [], "go_terms": [], "name": "WbnI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048175": {"description": "CD1290-like", "go_ids": [], "go_terms": [], "name": "CD1290-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048176": {"description": "TrbC, F-type conjugative transfer protein", "go_ids": [], "go_terms": [], "name": "TrbC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048178": {"description": "MobP1 relaxase-like", "go_ids": [], "go_terms": [], "name": "MobP1_relaxase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048179": {"description": "Anti-adapter protein SpxO-like", "go_ids": [], "go_terms": [], "name": "SpxO-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048180": {"description": "Toxin PezT", "go_ids": [], "go_terms": [], "name": "PezT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048181": {"description": "Antitoxin PezA", "go_ids": [], "go_terms": [], "name": "PezA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048182": {"description": "Malolactic enzyme", "go_ids": ["GO:0043464", "GO:0043883"], "go_terms": ["GO:0043464:L-malate catabolic process:P", "GO:0043883:malolactic enzyme activity:F"], "name": "Malolactic_enz", "pathway_ids": ["PWY-7685"], "pathways": ["PWY-7685:t:L-malate degradation I"], "type": "Family"}, "IPR048183": {"description": "GlnX-like", "go_ids": [], "go_terms": [], "name": "GlnX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048185": {"description": "Type 8 capsular polysaccharide synthesis protein Cap8I-like", "go_ids": [], "go_terms": [], "name": "Cap8I-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048186": {"description": "Anti-sigma E factor RseA-like", "go_ids": [], "go_terms": [], "name": "Anti_sigE_RseA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048187": {"description": "General secretion pathway protein N-like, Xanthomonas", "go_ids": [], "go_terms": [], "name": "XpsN-like_Xanth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048188": {"description": "YmfL-like", "go_ids": [], "go_terms": [], "name": "YmfL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048189": {"description": "Type I toxin DinQ-like", "go_ids": [], "go_terms": [], "name": "DinQ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048190": {"description": "YkgR-like", "go_ids": [], "go_terms": [], "name": "YkgR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048191": {"description": "YoaI-like", "go_ids": [], "go_terms": [], "name": "YoaI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048192": {"description": "YoaI/YldA-like", "go_ids": [], "go_terms": [], "name": "YoaI/YldA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048193": {"description": "YnaM/YnfT", "go_ids": [], "go_terms": [], "name": "YnaM_YnfT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048194": {"description": "Small, acid-soluble spore protein M", "go_ids": [], "go_terms": [], "name": "SspM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048195": {"description": "Outer membrane protein OmpB, Rickettsia", "go_ids": [], "go_terms": [], "name": "OmpB_ricketsia", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048196": {"description": "Ornithine lipid N-methyltransferase", "go_ids": [], "go_terms": [], "name": "Ornithlipidmtase_OlsG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048197": {"description": "Papain inhibitor", "go_ids": ["GO:0004867", "GO:0004869"], "go_terms": ["GO:0004867:serine-type endopeptidase inhibitor activity:F", "GO:0004869:cysteine-type endopeptidase inhibitor activity:F"], "name": "Papain_inhib", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048198": {"description": "Sporulation membrane protein YtrI", "go_ids": [], "go_terms": [], "name": "YtrI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048199": {"description": "Stage II sporulation protein SB-like", 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"IPR048270": {"description": "Paraneoplastic antigen Ma-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PNMA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048271": {"description": "Paraneoplastic antigen Ma-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PNMA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048272": {"description": "Distal tail protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Dit_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048273": {"description": "Luciferase", "go_ids": [], "go_terms": [], "name": "Luciferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048274": {"description": "Mesaconyl-CoA hydratase", "go_ids": ["GO:0016829"], "go_terms": ["GO:0016829:lyase activity:F"], "name": "MC_hydratase", "pathway_ids": ["PWY-7854", "PWY-6728", "PWY-5741", "PWY-5744"], "pathways": ["PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", 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"R-HSA-114608", "R-HSA-9638630", "R-MMU-8874081", "R-MMU-3000171", "R-MMU-3000178", "R-HSA-8948216", "R-RNO-419037", "R-DRE-1650814", "R-RNO-3000178", "R-HSA-1442490", "R-RNO-3000171", "R-HSA-9925563", "R-RNO-1650814", "R-HSA-216083", "R-MMU-1566977", "R-HSA-3000170", "R-MMU-1592389", "R-RNO-1566977", "R-HSA-5083635", "R-RNO-8948216", "R-HSA-1566977", "R-RNO-186797", "R-HSA-3000171", "R-HSA-428542", "R-HSA-1592389", "R-RNO-1442490", "R-HSA-419037", "R-MMU-2022090", "R-HSA-2022090", "R-HSA-5173214", "R-MMU-1650814", "R-MMU-5173214", "R-MMU-216083", "R-MMU-186797", "R-MMU-1442490", "R-MMU-114608", "R-MMU-419037"], "pathways": ["R-HSA-186797:r:Signaling by PDGF", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-3000157:r:Laminin interactions", "R-MMU-8948216:r:Collagen chain trimerization", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-8948216:r:Collagen chain trimerization", "R-RNO-419037:r:NCAM1 interactions", "R-DRE-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-1442490:r:Collagen degradation", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1566977:r:Fibronectin matrix formation", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-RNO-8948216:r:Collagen chain trimerization", "R-HSA-1566977:r:Fibronectin matrix formation", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1442490:r:Collagen degradation", "R-HSA-419037:r:NCAM1 interactions", "R-MMU-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-186797:r:Signaling by PDGF", "R-MMU-1442490:r:Collagen degradation", "R-MMU-114608:r:Platelet degranulation", "R-MMU-419037:r:NCAM1 interactions"], "type": "Domain"}, "IPR048288": {"description": "Programmed cell death protein 10, dimerisation domain", "go_ids": [], "go_terms": [], "name": "PDCD10_N", "pathway_ids": ["R-CEL-75153", "R-HSA-111465", "R-HSA-75153", "R-DDI-75153", "R-MMU-111465", "R-RNO-75153", "R-MMU-75153", "R-RNO-111465"], "pathways": ["R-CEL-75153:r:Apoptotic execution phase", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-75153:r:Apoptotic execution phase", "R-DDI-75153:r:Apoptotic execution phase", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-75153:r:Apoptotic execution phase", "R-MMU-75153:r:Apoptotic execution phase", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Domain"}, "IPR048291": {"description": "Phage tail fibre adhesin Gp38, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Gp38_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048292": {"description": "SDA1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SDA1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048294": {"description": "Reovirus core-spike protein lambda-2-like, C-terminal domain", "go_ids": ["GO:0019028"], "go_terms": ["GO:0019028:viral capsid:C"], "name": "Reovirus_L2_8th", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Domain"}, "IPR048295": {"description": "DUF4785, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF4785_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048296": {"description": "DUF4785, central domain", "go_ids": [], "go_terms": [], "name": "DUF4785_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048297": {"description": "CORD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CORD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048298": {"description": "Influenza RNA polymerase PB2, CAP binding domain", "go_ids": [], "go_terms": [], "name": "Flu_PB2_CAP-bd", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-168275", "R-HSA-192814", "R-HSA-192905", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Domain"}, "IPR048299": {"description": "Group II intron-interrupted relaxase LtrB, central domain", "go_ids": [], "go_terms": [], "name": "LtrB_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048300": {"description": "TACO1/YebC-like, second and third domains", "go_ids": [], "go_terms": [], "name": "TACO1_YebC-like_2nd/3rd_dom", "pathway_ids": ["R-HSA-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly"], "type": "Domain"}, "IPR048301": {"description": "Endonuclease NucS, C-terminal domain", "go_ids": ["GO:0004519"], "go_terms": ["GO:0004519:endonuclease activity:F"], "name": "NucS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048302": {"description": "Endonuclease NucS, N-terminal PH-like domain", "go_ids": [], "go_terms": [], "name": "NucS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048303": {"description": "Type VI lipase adapter protein Tla3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tla3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048304": {"description": "3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like, Rift-related domain", "go_ids": [], "go_terms": [], "name": "UbiD_Rift_dom", "pathway_ids": ["PWY-6978", "PWY-5856", "PWY-6708", "PWY-5857", "PWY-5855"], "pathways": ["PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)"], "type": "Domain"}, "IPR048305": {"description": "PAE0736-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PAE0736-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048306": {"description": "Rotavirus non-structural protein 35, C-terminal domain", "go_ids": ["GO:0004550", "GO:0017111"], "go_terms": ["GO:0004550:nucleoside diphosphate kinase activity:F", "GO:0017111:ribonucleoside triphosphate phosphatase activity:F"], "name": "Rota_NS35_C", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR048307": {"description": "Oligosaccharyl transferase STT3, N-terminal domain", "go_ids": ["GO:0016020"], "go_terms": ["GO:0016020:membrane:C"], "name": "STT3_N", "pathway_ids": ["R-MMU-9931295", "R-BTA-9931295", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9918432", "R-BTA-9768727", "R-HSA-9926550", "R-CFA-9931295", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-9931295"], "pathways": ["R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Domain"}, "IPR048308": {"description": "G6b-B extracellular V-set Ig-like domain", "go_ids": [], "go_terms": [], "name": "G6B_V-set", "pathway_ids": ["R-RNO-114604", "R-MMU-114604", "R-HSA-114604"], "pathways": ["R-RNO-114604:r:GPVI-mediated activation cascade", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-114604:r:GPVI-mediated activation cascade"], "type": "Domain"}, "IPR048309": {"description": "GxGYxYP putative glycoside hydrolase, third N-terminal domain", "go_ids": [], "go_terms": [], "name": "GxGYxYP_N_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048310": {"description": "GxGYxYP putative glycoside hydrolase, second N-terminal domain", "go_ids": [], "go_terms": [], "name": "GxGYxYP_N_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048311": {"description": "Antiactivator protein ExsD, helical hairpin domain", "go_ids": [], "go_terms": [], "name": "ExsD_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048312": {"description": "Antiactivator protein ExsD, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ExsD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048313": {"description": "DUF5382, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF5382_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048314": {"description": "DUF5382, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF5382_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048315": {"description": "ZSWIM9, central RNaseH-like domain", "go_ids": [], "go_terms": [], "name": "ZSWIM9_RNaseH-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048316": {"description": "DUF5580, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF5580_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048317": {"description": "DUF5581, Fn3-like domain", "go_ids": [], "go_terms": [], "name": "DUF5581_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048318": {"description": "Autophagy protein ATG5, UblB domain", "go_ids": [], "go_terms": [], "name": "ATG5_UblB", "pathway_ids": ["R-HSA-8934903", "R-DDI-1632852", "R-MMU-8934903", "R-RNO-8934903", "R-RNO-5205685", "R-CEL-8934903", "R-BTA-5205685", "R-CEL-1632852", "R-MMU-1632852", "R-HSA-936440", "R-CEL-5205685", "R-MMU-5205685", "R-BTA-1632852", "R-SCE-1632852", "R-SPO-8934903", "R-RNO-1632852", "R-BTA-8934903", "R-SCE-8934903", "R-HSA-1632852", "R-DME-1632852", "R-HSA-5205685", "R-SPO-1632852"], "pathways": ["R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DDI-1632852:r:Macroautophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-1632852:r:Macroautophagy", "R-SCE-1632852:r:Macroautophagy", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-1632852:r:Macroautophagy", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-1632852:r:Macroautophagy"], "type": "Domain"}, "IPR048319": {"description": "Vps52, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "Vps52_CC", "pathway_ids": ["R-HSA-6811440", "R-RNO-6811440", "R-CFA-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-CFA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR048320": {"description": "Conserved oligomeric Golgi complex subunit 3, N-terminal", "go_ids": [], "go_terms": [], "name": "COG3_N", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-HSA-6807878", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR048321": {"description": "Nuclear cap binding complex subunit CBP66, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CBP66_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048322": {"description": "Nuclear cap binding complex subunit CBP66, second domain", "go_ids": [], "go_terms": [], "name": "CBP66_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048323": {"description": "Spo16 protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Spo16_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048324": {"description": "ZSWIM1/3, RNaseH-like domain", "go_ids": [], "go_terms": [], "name": "ZSWIM1-3_RNaseH-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048325": {"description": "ZSWIM3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ZSWIM3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048326": {"description": "ZSWIM1/3, helical domain", "go_ids": [], "go_terms": [], "name": "ZSWIM1-3_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048327": {"description": "Dyp-type peroxidase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Dyp_perox_N", "pathway_ids": ["PWY-5292", "R-HSA-9638482"], "pathways": ["PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR048328": {"description": "Dyp-type peroxidase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Dyp_perox_C", "pathway_ids": ["PWY-5292", "R-HSA-9638482"], "pathways": ["PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR048329": {"description": "PcRGLX/YetA-like, N-terminal RIFT barrel domain", "go_ids": [], "go_terms": [], "name": "PcRGLX_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048330": {"description": "PcRGLX/YetA-like, central beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "PcRGLX/YetA_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048331": {"description": "PcRGLX/YetA-like, C-terminal alpha/alpha toroid domain", "go_ids": [], "go_terms": [], "name": "PcRGLX/YetA_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048332": {"description": "D-galactarate/Altronate dehydratase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GD_AH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048333": {"description": "Helicase associated domain (HA2), winged-helix domain", "go_ids": [], "go_terms": [], "name": "HA2_WH", "pathway_ids": ["R-CEL-3134963", "R-HSA-9930044", "R-HSA-9833482", "R-MMU-9770562", "R-DME-1810476", "R-HSA-73856", "R-DME-72163", "R-DDI-9770562", "R-CEL-73856", "R-HSA-72187", "R-RNO-3134963", "R-MMU-3134963", "R-DDI-72163", "R-HSA-6790901", "R-DME-9770562", "R-MMU-9833482", "R-HSA-3134963", "R-SCE-6791226", "R-CEL-9770562", "R-MMU-1810476", "R-CEL-6791226", "R-BTA-3134963", "R-CEL-72163", "R-HSA-9918481", "R-BTA-72163", "R-MMU-9930044", "R-HSA-9770562", "R-MMU-72163", "R-BTA-73856", "R-CEL-9833482", "R-DME-9833482", "R-HSA-1810476", "R-SPO-9770562", "R-HSA-72163", "R-BTA-1810476", "R-HSA-6791226", "R-BTA-9770562", "R-BTA-159236", "R-HSA-159236", "R-SPO-72163", "R-SPO-6791226", "R-BTA-9833482", "R-DME-3134963", "R-CEL-159236"], "pathways": ["R-CEL-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-9770562:r:mRNA Polyadenylation", "R-DME-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-RNO-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-MMU-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-9833482:r:PKR-mediated signaling", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-9833482:r:PKR-mediated signaling", "R-DME-3134963:r:DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Domain"}, "IPR048334": {"description": "Pellino, FHA domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Pellino_FHA", "pathway_ids": ["PWY-7511", "R-DME-975144", "R-HSA-9020702", "R-MMU-975144", "R-MMU-937039", "R-HSA-975144", "R-HSA-5675482", "R-MMU-5675482", "R-MMU-9020702", "R-DME-9020702", "R-HSA-937039", "R-DME-937039"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-9020702:r:Interleukin-1 signaling", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-DME-937039:r:IRAK1 recruits IKK complex"], "type": "Domain"}, "IPR048335": {"description": "Pellino, RING domain", "go_ids": [], "go_terms": [], "name": "Pellino_RING", "pathway_ids": ["PWY-7511", "R-DME-975144", "R-HSA-9020702", "R-MMU-975144", "R-MMU-937039", "R-HSA-975144", "R-HSA-5675482", "R-MMU-5675482", "R-MMU-9020702", "R-DME-9020702", "R-HSA-937039", "R-DME-937039"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-9020702:r:Interleukin-1 signaling", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-DME-937039:r:IRAK1 recruits IKK complex"], "type": "Domain"}, "IPR048336": {"description": "Cysteine protease StiP-like", "go_ids": [], "go_terms": [], "name": "StiP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048337": {"description": "FAM50A/XAP5, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FAM50A/XAP5_C", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-DME-72163", "R-CEL-72163", "R-DDI-72163", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR048338": {"description": "Mediator complex, subunit Med16", "go_ids": [], "go_terms": [], "name": "Mediator_Med16", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Family"}, "IPR048339": {"description": "Mediator complex subunit 16, C-terminal", "go_ids": [], "go_terms": [], "name": "Mediator_Med16_C", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR048341": {"description": "DUF1285, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF1285_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048342": {"description": "DUF1285, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF1285_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048343": {"description": "Centromere/kinetochore protein zw10, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ZW10_C", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-6811434", "R-RNO-2500257", "R-MMU-2467813", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-RNO-5663220", "R-DME-6811434", "R-HSA-6811434", "R-HSA-68877", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-MMU-9648025", "R-CEL-6811434", "R-MMU-5663220", "R-RNO-141444", "R-MMU-6811434"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR048344": {"description": "Centromere/kinetochore protein zw10, middle domain", "go_ids": [], "go_terms": [], "name": "Zw10_middle", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-6811434", "R-RNO-2500257", "R-MMU-2467813", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-RNO-5663220", "R-DME-6811434", "R-HSA-6811434", "R-HSA-68877", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-MMU-9648025", "R-CEL-6811434", "R-MMU-5663220", "R-RNO-141444", "R-MMU-6811434"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR048345": {"description": "Plasmid segregation protein ParM, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ParM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048346": {"description": "Sarcoglycan alpha/epsilon, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Sarcoglycan_N", "pathway_ids": ["R-HSA-9913351", "R-MMU-9913351", "R-RNO-9913351"], "pathways": ["R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Domain"}, "IPR048347": {"description": "Sarcoglycan alpha/epsilon second domain", "go_ids": [], "go_terms": [], "name": "Sarcoglycan_C", "pathway_ids": ["R-HSA-9913351", "R-MMU-9913351", "R-RNO-9913351"], "pathways": ["R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Domain"}, "IPR048348": {"description": "CCDC22, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CCDC22_CC", "pathway_ids": ["R-DRE-8951664", "R-MMU-8951664", "R-BTA-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-DDI-8951664", "R-DME-8951664"], "pathways": ["R-DRE-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation"], "type": "Domain"}, "IPR048349": {"description": "CCDC22, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CCDC22_N", "pathway_ids": ["R-DRE-8951664", "R-MMU-8951664", "R-BTA-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-DDI-8951664", "R-DME-8951664"], "pathways": ["R-DRE-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation"], "type": "Domain"}, "IPR048350": {"description": "S-Me-THD-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "S-Me-THD-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048351": {"description": "SOSEKI, DIX-like domain", "go_ids": [], "go_terms": [], "name": "SOK_DIX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048354": {"description": "TOD1/MUCI70, glycosyltransferase-like domain", "go_ids": [], "go_terms": [], "name": "TOD1_MUCI70_glycTrfase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048355": {"description": "Malate synthase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MS_C", "pathway_ids": ["PWY-7854", "PWY-7295", "PWY-7118", "PWY-7294"], "pathways": ["PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7295:t:L-arabinose degradation IV", "PWY-7118:t:chitin deacetylation", "PWY-7294:t:D-xylose degradation IV"], "type": "Domain"}, "IPR048356": {"description": "Malate synthase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MS_N", "pathway_ids": ["PWY-7854", "PWY-7295", "PWY-7118", "PWY-7294"], "pathways": ["PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7295:t:L-arabinose degradation IV", "PWY-7118:t:chitin deacetylation", "PWY-7294:t:D-xylose degradation IV"], "type": "Domain"}, "IPR048357": {"description": "Malate synthase G, alpha-beta insertion domain", "go_ids": [], "go_terms": [], "name": "MSG_insertion", "pathway_ids": ["PWY-7854", "PWY-7295", "PWY-7118", "PWY-7294"], "pathways": ["PWY-7854:t:crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)", "PWY-7295:t:L-arabinose degradation IV", "PWY-7118:t:chitin deacetylation", "PWY-7294:t:D-xylose degradation IV"], "type": "Domain"}, "IPR048358": {"description": "EZH1/2, MCSS domain", "go_ids": [], "go_terms": [], "name": "EZH1/2_MCSS", "pathway_ids": ["R-DME-9909649", "R-MMU-8953750", "R-HSA-5617472", "R-MMU-3214841", "R-HSA-2559580", "R-DME-212300", "R-DRE-2559580", "R-XTR-212300", "R-XTR-9764725", "R-DRE-8953750", "R-HSA-9764725", "R-MMU-212300", "R-HSA-8953750", "R-HSA-9609690", "R-MMU-9764725", "R-MMU-2559580", "R-MMU-8943724", "R-HSA-9710421", "R-DME-2559580", "R-XTR-8953750", "R-HSA-212300", "R-HSA-9909649", "R-XTR-9909649", "R-DRE-3214841", "R-HSA-3214841", "R-MMU-9909649", "R-BTA-212300", "R-HSA-8943724", "R-DME-9764725", "R-DME-8953750", "R-XTR-2559580", "R-DRE-212300", "R-DRE-9909649", "R-DME-8943724", "R-DRE-9764725"], "pathways": ["R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9710421:r:Defective pyroptosis", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription"], "type": "Domain"}, "IPR048359": {"description": "Exocyst complex component EXOC6/Sec15, N-terminal domain", "go_ids": [], "go_terms": [], "name": "EXOC6_Sec15_N", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Domain"}, "IPR048360": {"description": "EZH2, preSET CXC domain, fungi", "go_ids": [], "go_terms": [], "name": "Ezh2_CXC_fung", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048361": {"description": "Vps52, C-terminal", "go_ids": [], "go_terms": [], "name": "Vps52_C", "pathway_ids": ["R-HSA-6811440", "R-RNO-6811440", "R-CFA-6811440", "R-MMU-6811440"], "pathways": ["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-CFA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR048362": {"description": "Poly (ADP-ribose) glycohydrolase, helical domain", "go_ids": [], "go_terms": [], "name": "PARG_helical", "pathway_ids": ["R-HSA-110362", "R-MMU-110362", "R-RNO-110362"], "pathways": ["R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair"], "type": "Domain"}, "IPR048363": {"description": "Cation channel sperm-associated targeting subunit tau, C2 domain", "go_ids": [], "go_terms": [], "name": "CTSRT_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048364": {"description": "Hikeshi-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Hikeshi-like_C", "pathway_ids": ["R-SCE-3371453", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-DME-3371453", "R-DDI-3371453", "R-BTA-3371453", "R-XTR-3371453", "R-DRE-3371453", "R-MMU-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DDI-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR048365": {"description": "Transposable element P transposase-like, RNase H domain, N-terminal", "go_ids": [], "go_terms": [], "name": "TNP-like_RNaseH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048366": {"description": "Transposable element P transposase-like, GTP-binding insertion domain", "go_ids": [], "go_terms": [], "name": "TNP-like_GBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048367": {"description": "Transposable element P transposase-like, RNase H, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TNP-like_RNaseH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048368": {"description": "Conserved oligomeric complex COG6, N-terminal", "go_ids": [], "go_terms": [], "name": "COG6_N", "pathway_ids": ["R-RNO-6811440", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-RNO-6807878", "R-RNO-6811438", "R-HSA-6807878", "R-CEL-6807878", "R-CEL-6811438", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR048369": {"description": "Conserved Oligomeric Golgi complex subunit 6, C-terminal", "go_ids": [], "go_terms": [], "name": "COG6_C", "pathway_ids": ["R-RNO-6811440", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-RNO-6807878", "R-RNO-6811438", "R-HSA-6807878", "R-CEL-6807878", "R-CEL-6811438", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR048370": {"description": "ZSWIM4-8, C-terminal", "go_ids": [], "go_terms": [], "name": "ZSWIM4-8_C", "pathway_ids": ["R-HSA-9010553"], "pathways": ["R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs"], "type": "Domain"}, "IPR048371": {"description": "Zinc finger HIT domain-containing protein 3, C-terminal domain", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "ZNHIT3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048372": {"description": "Cell-division protein ZapC, C-terminal", "go_ids": [], "go_terms": [], "name": "ZapC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048373": {"description": "Cell-division protein ZapC, N-terminal", "go_ids": [], "go_terms": [], "name": "ZapC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048374": {"description": "YuA phage, Gp49-like", "go_ids": [], "go_terms": [], "name": "YuA_Gp49-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048375": {"description": "YtxK-like, N-terminal helical domain", "go_ids": [], "go_terms": [], "name": "YtxK-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048376": {"description": "Inner membrane protein YqiJ, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YqiJ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048378": {"description": "Biogenesis factor required for ATP synthase 1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BFA1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048379": {"description": "Rad26-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Rad26-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048380": {"description": "Rad26-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Rad26-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048381": {"description": "NAD-specific glutamate dehydrogenase, C-terminal", "go_ids": [], "go_terms": [], "name": "GDH_C", "pathway_ids": ["PWY-6728", "PWY-5022", "PWY-7126", "PWY-8190"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-7126:t:ethene biosynthesis IV (engineered)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)"], "type": "Domain"}, "IPR048382": {"description": "BCAS3, WD40 domain", "go_ids": [], "go_terms": [], "name": "BCAS3_WD40", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048383": {"description": "Tripeptidyl-peptidase II, first Ig-like domain", "go_ids": [], "go_terms": [], "name": "TPPII_Ig-like-1", "pathway_ids": ["R-SPO-983168", "R-DME-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-MMU-983168"], "pathways": ["R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR048384": {"description": "Tripeptidyl-peptidase II, galactose-binding domain-like", "go_ids": [], "go_terms": [], "name": "TPPII_GBD", "pathway_ids": ["R-SPO-983168", "R-DME-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-MMU-983168"], "pathways": ["R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR048385": {"description": "ARC105/Med15 mediator subunit, central domain", "go_ids": [], "go_terms": [], "name": "Med15_central", "pathway_ids": ["R-HSA-1989781", "R-HSA-212436", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR048386": {"description": "ARC105/Med15 mediator subunit, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Med15_C", "pathway_ids": ["R-HSA-1989781", "R-HSA-212436", "R-HSA-9833110", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR048387": {"description": "T-box transcription factor 2/3, repressor domain", "go_ids": [], "go_terms": [], "name": "TBX2_3_RD", "pathway_ids": ["R-MMU-9856649", "R-HSA-9825892", "R-HSA-9856649", "R-RNO-9856649"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity"], "type": "Domain"}, "IPR048388": {"description": "Tail fibre protein gp37, trimerization region", "go_ids": [], "go_terms": [], "name": "Gp37_trimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048389": {"description": "Predicted membrane protein YciQ-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YciQ-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048390": {"description": "Long-tail fiber proximal subunit, trimerization domain", "go_ids": [], "go_terms": [], "name": "Gp34_trimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048391": {"description": "Long-tail fiber proximal subunit domain", "go_ids": [], "go_terms": [], "name": "Gp34_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048392": {"description": "Exosome RNA helicase MTR4-like, stalk", "go_ids": [], "go_terms": [], "name": "MTR4-like_stalk", "pathway_ids": ["R-MMU-9930044", "R-MMU-6791226", "R-HSA-9930044", "R-HSA-390471", "R-MMU-72163", "R-MMU-429958", "R-SPO-9930044", "R-HSA-72163", "R-SCE-429958", "R-SCE-6791226", "R-HSA-6791226", "R-HSA-9843970", "R-CEL-9930044", "R-CEL-6791226", "R-HSA-429958", "R-CEL-72163", "R-SPO-429958", "R-SPO-72163", "R-SPO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR048394": {"description": "Fatty acid kinase subunit A-like, middle domain", "go_ids": [], "go_terms": [], "name": "FakA-like_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048395": {"description": "Glycosyl hydrolase family 31, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_31_C", "pathway_ids": ["R-MMU-70221", "R-HSA-6798695", "R-HSA-189085", "R-SPO-6798695", "R-HSA-70221", "R-HSA-532668", "R-HSA-9683686", "R-HSA-9694548", "R-HSA-5357609", "R-MMU-9768727", "R-BTA-6798695", "R-MMU-189085", "R-RNO-70221", "R-SPO-189085", "R-SPO-70221", "R-HSA-5659898", "R-MMU-6798695", "R-RNO-189085", "R-HSA-9768727", "R-HSA-901042", "R-SSC-189085", "R-RNO-6798695", "R-BTA-70221"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-189085:r:Digestion of dietary carbohydrate", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-5357609:r:Glycogen storage disease type II (GAA)", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-189085:r:Digestion of dietary carbohydrate", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-SPO-189085:r:Digestion of dietary carbohydrate", "R-SPO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-5659898:r:Intestinal saccharidase deficiencies", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-189085:r:Digestion of dietary carbohydrate", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-901042:r:Calnexin/calreticulin cycle", "R-SSC-189085:r:Digestion of dietary carbohydrate", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-70221:r:Glycogen breakdown (glycogenolysis)"], "type": "Domain"}, "IPR048396": {"description": "Shedu protein SduA, N-terminal", "go_ids": [], "go_terms": [], "name": "SduA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048397": {"description": "Virus-capping methyltransferase, connector domain", "go_ids": [], "go_terms": [], "name": "Methyltrans_Mon_CD", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR048398": {"description": "Virus-capping methyltransferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Methyltrans_Mon_C", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR048399": {"description": "DUF4438, C-terminal", "go_ids": [], "go_terms": [], "name": "DUF4438_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048400": {"description": "SLS1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SLS1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048401": {"description": "SLS1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SLS1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048402": {"description": "Sporulation protein YpeB, N-terminal", "go_ids": [], "go_terms": 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"type": "Domain"}, "IPR048458": {"description": "MalQ, N-terminal beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "MalQ_N", "pathway_ids": ["PWY-7238", "PWY-6724", "PWY-6737"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6724:t:starch degradation II", "PWY-6737:t:starch degradation V"], "type": "Domain"}, "IPR048459": {"description": "DNA2, rift barrel domain", "go_ids": [], "go_terms": [], "name": "DNA2_Rift", "pathway_ids": ["R-BTA-69473", "R-RNO-174437", "R-BTA-5685938", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-MMU-6804756", "R-BTA-174437", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-RNO-69166", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-174437", "R-BTA-6804756", "R-BTA-69166", "R-RNO-5685938", "R-BTA-5693616", "R-MMU-174437", "R-RNO-6804756", "R-BTA-5693579", "R-BTA-5693607", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-HSA-9701192", "R-RNO-5693579", "R-BTA-5693568", "R-HSA-69473", "R-RNO-5693607", "R-HSA-9709603", "R-MMU-5685942", "R-HSA-69166", "R-RNO-69473", "R-RNO-5685942", "R-HSA-6804756", "R-HSA-9704331", "R-MMU-69166", "R-RNO-5693568", "R-BTA-5685942", "R-RNO-5693616", "R-HSA-5693554", "R-HSA-5693579"], "pathways": ["R-BTA-69473:r:G2/M DNA damage checkpoint", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-69166:r:Removal of the Flap Intermediate", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange"], "type": "Domain"}, "IPR048460": {"description": "Dermonecrotic toxin, C3 domain", "go_ids": [], "go_terms": [], "name": "ToxA_C3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048461": {"description": "Dermonecrotic toxin-like, C2 domain", "go_ids": [], "go_terms": [], "name": "ToxA-like_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048462": {"description": "YDR124W, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YDR124W_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048463": {"description": "YchJ-like, zinc-binding domain", "go_ids": [], "go_terms": [], "name": "YchJ-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048464": {"description": "MalF, N-terminal region, transmembrane helices", "go_ids": [], "go_terms": [], "name": "MalF_N_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048465": {"description": "Maestro-like, HEAT-repeats domain", "go_ids": [], "go_terms": [], "name": "Maestro-like_HEAT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048466": {"description": "DNA polymerase III delta subunit-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DNA_pol3_delta-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048467": {"description": "MACPF protein, D3 domain", "go_ids": [], "go_terms": [], "name": "MACPF_D3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048468": {"description": "MACPF protein, D2 domain", "go_ids": [], "go_terms": [], "name": "MACPF_D2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048469": {"description": "YchJ-like, middle NTF2-like domain", "go_ids": [], "go_terms": [], "name": "YchJ-like_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048470": {"description": "Mevalonate-3-kinase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "M3K_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048471": {"description": "Mevalonate-3-kinase", "go_ids": [], "go_terms": [], "name": "M3K", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048472": {"description": "DNA polymerase III subunit alpha, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DNA_pol_IIIA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048473": {"description": "Integron cassette protein", "go_ids": [], "go_terms": [], "name": "M1E1E6-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048474": {"description": "Integron cassette protein superfamily", "go_ids": [], "go_terms": [], "name": "M1E1E6-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR048475": {"description": "MG281-like, antibody-binding region", "go_ids": [], "go_terms": [], "name": "MG281-like_Ab-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048476": {"description": "LytM, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LytM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048477": {"description": "YceM-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YceM-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048478": {"description": "LSM12, LSM domain", "go_ids": [], "go_terms": [], "name": "LSM12_LSM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048479": {"description": "Ybfg-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ybfg_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048481": {"description": "LRIM1/APL1C-like, dimerization domain", "go_ids": [], "go_terms": [], "name": "LRIM1_APL1C-like_dimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048482": {"description": "GH141-like, insertion domain", "go_ids": [], "go_terms": [], "name": "GH141_ins", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048483": {"description": "Lpg1496-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Lpg1496-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048484": {"description": "APOLTP domain", "go_ids": [], "go_terms": [], "name": "APOLTP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048485": {"description": "Conserved oligomeric Golgi complex subunit 5, helical domain", "go_ids": [], "go_terms": [], "name": "COG5_helical", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-HSA-6807878", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR048486": {"description": "Phosphoprotein, C-terminal domain, cytorhabdovirus", "go_ids": [], "go_terms": [], "name": "PP_C_cytorhabdovirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048487": {"description": "DnaK suppressor protein-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DksA-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048488": {"description": "1,3-alpha-isomaltosidase-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AIMA-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048489": {"description": "DnaK suppressor protein DksA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DksA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048490": {"description": "Type III effector Xcv3220-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "XopL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048491": {"description": "XMAP215/Dis1/CLASP, TOG domain", "go_ids": ["GO:0015631"], "go_terms": ["GO:0015631:tubulin binding:F"], "name": "XMAP215_CLASP_TOG", "pathway_ids": ["R-HSA-2467813", "R-MMU-2467813", "R-HSA-380284", "R-MMU-68877", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942", "R-HSA-380320", "R-HSA-68877", "R-MMU-5620912", "R-HSA-5620912", "R-MMU-9648025", "R-MMU-2500257", "R-MMU-141444", "R-MMU-380259", "R-HSA-2500257", "R-MMU-380270", "R-HSA-141444", "R-HSA-380270", "R-HSA-9648025", "R-MMU-8854518", "R-HSA-5663220", "R-HSA-428890", "R-HSA-380259", "R-MMU-5663220"], "pathways": ["R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR048492": {"description": "Stu2, C-terminal segment", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "Stu2_CTS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048493": {"description": "DUF1980, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF1980_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048494": {"description": "Dit-like phage tail protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Dit-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048495": {"description": "Lincosamide nucleotidyltransferase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LinB-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048496": {"description": "DUF1846, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF1846_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048497": {"description": "Leukemia inhibitory factor receptor-like, Ig-like domain", "go_ids": [], "go_terms": [], "name": "LIF-R-like_Ig-like", "pathway_ids": ["R-MMU-6788467", "R-HSA-8939247", "R-HSA-6788467", "R-RNO-6788467"], "pathways": ["R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Domain"}, "IPR048498": {"description": "USP8, WW domain", "go_ids": [], "go_terms": [], "name": "WW_USP8", "pathway_ids": ["R-MMU-5689880", "R-MMU-4641263", "R-HSA-5689880", "R-HSA-4641263", "R-MMU-6807004", "R-HSA-6807004", "R-HSA-1358803", "R-MMU-1358803"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling"], "type": "Domain"}, "IPR048499": {"description": "Dickkopf-related protein 1/2/4, C-terminal subdomain 2", "go_ids": [], "go_terms": [], "name": "DIKK1/2/4_C-subdom2", "pathway_ids": ["R-HSA-3772470", "R-HSA-201681", "R-MMU-3772470", "R-HSA-5339717"], "pathways": ["R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-5339717:r:Signaling by LRP5 mutants"], "type": "Domain"}, "IPR048500": {"description": "Dickkopf-related protein 1/2/4, C-terminal subdomain 1", "go_ids": [], "go_terms": [], "name": "DIKK1/2/4_C-subdom1", "pathway_ids": ["R-HSA-3772470", "R-HSA-201681", "R-MMU-3772470", "R-HSA-5339717"], "pathways": ["R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-5339717:r:Signaling by LRP5 mutants"], "type": "Domain"}, "IPR048501": {"description": "Legumain, prodomain", "go_ids": [], "go_terms": [], "name": "Legum_prodom", "pathway_ids": ["R-MMU-1679131", "R-HSA-1679131", "R-HSA-196791", "R-HSA-2132295", "R-RNO-196791", "R-RNO-2132295", "R-RNO-1679131", "R-MMU-2132295"], "pathways": ["R-MMU-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-1679131:r:Trafficking and processing of endosomal TLR", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-1679131:r:Trafficking and processing of endosomal TLR", "R-MMU-2132295:r:MHC class II antigen presentation"], "type": "Domain"}, "IPR048502": {"description": "Peptidoglycan beta-N-acetylmuramidase NamZ, N-terminal", "go_ids": [], "go_terms": [], "name": "NamZ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048503": {"description": "Peptidoglycan beta-N-acetylmuramidase NamZ, C-terminal", "go_ids": [], "go_terms": [], "name": "NamZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048504": {"description": "Dicers-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Dicers-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048505": {"description": "Dicers-like, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Dicers-like_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR048506": {"description": "LED repeat", "go_ids": [], "go_terms": [], "name": "LED_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR048507": {"description": "WKTW repeat", "go_ids": [], "go_terms": [], "name": "WKTW_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR048508": {"description": "Alpha-galactosyl binding lectin", "go_ids": [], "go_terms": [], "name": "LDL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048509": {"description": "Transmembrane protein 106, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TMEM106_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048510": {"description": "WsaF, N-terminal domain", "go_ids": ["GO:0030247"], "go_terms": ["GO:0030247:polysaccharide binding:F"], "name": "WsaF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048511": {"description": "Transmembrane protein 106, N-terminal", "go_ids": [], "go_terms": [], "name": "TMEM106_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048512": {"description": "Dicer, platform domain", "go_ids": [], "go_terms": [], "name": "Dicer_platform", "pathway_ids": ["R-CEL-426486", "R-MMU-426486", "R-HSA-426486", "R-DME-203927", "R-MMU-203927", "R-HSA-9824594", "R-HSA-203927", "R-XTR-426486", "R-CEL-203927", "R-HSA-9820841", "R-HSA-9708296", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR048513": {"description": "Dicer, partner-binding domain", "go_ids": [], "go_terms": [], "name": "Dicer_PBD", "pathway_ids": ["R-CEL-426486", "R-MMU-426486", "R-HSA-426486", "R-DME-203927", "R-MMU-203927", "R-HSA-9824594", "R-HSA-203927", "R-XTR-426486", "R-CEL-203927", "R-HSA-9820841", "R-HSA-9708296", "R-DME-426486", "R-XTR-203927"], "pathways": ["R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-XTR-426486:r:Small interfering RNA (siRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-HSA-9708296:r:tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis", "R-XTR-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR048514": {"description": "DWD hypersensitive to UV-B 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DHU1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048515": {"description": "DHH-CID domain", "go_ids": [], "go_terms": [], "name": "DHH_CID", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048516": {"description": "DGC-associated coil", "go_ids": [], "go_terms": [], "name": "DGCcoil", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048517": {"description": "DENR, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DENR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048518": {"description": "Ice-binding protein, beta roll", "go_ids": [], "go_terms": [], "name": "IBP_b_roll", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR048519": {"description": "Gfd2/YDR514C-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gfd2/YDR514C-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048520": {"description": "Lactate racemase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LarA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048521": {"description": "WipA-like, phosphatase domain", "go_ids": ["GO:0016791"], "go_terms": ["GO:0016791:phosphatase activity:F"], "name": "WipA_Phos", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048522": {"description": "Death domain, fish", "go_ids": [], "go_terms": [], "name": "Death_3_fish", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048523": {"description": "Protein LANA1-like, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "LANA1_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048524": {"description": "Lysosome-associated membrane glycoprotein 2-like, transmembrane domain", "go_ids": [], "go_terms": [], "name": "Lamp2-like_TM", "pathway_ids": ["R-HSA-6798695", "R-HSA-114608", "R-CEL-6798695", "R-HSA-9613829", "R-MMU-6798695", "R-CEL-114608", "R-BTA-6798695", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-114608:r:Platelet degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR048525": {"description": "Discoidin domain-containing receptor 1/2, DS-like domain", "go_ids": [], "go_terms": [], "name": "DDR1-2_DS-like", "pathway_ids": ["R-HSA-3000171", "R-RNO-3000171", "R-CEL-3000171", "R-MMU-3000171"], "pathways": ["R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-RNO-3000171:r:Non-integrin membrane-ECM interactions", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions"], "type": "Domain"}, "IPR048526": {"description": "WipA, alpha-helical hairpin", "go_ids": ["GO:0005515"], "go_terms": ["GO:0005515:protein binding:F"], "name": "WipA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048527": {"description": "Cellulose-binding Sde182, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Sde182_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048528": {"description": "Lysosome-associated membrane glycoprotein 2-like, luminal domains", "go_ids": [], "go_terms": [], "name": "Lamp2-like_luminal", "pathway_ids": ["R-HSA-6798695", "R-HSA-114608", "R-HSA-9613829", "R-MMU-6798695", "R-BTA-6798695", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR048529": {"description": "GP38, nairovirus", "go_ids": [], "go_terms": [], "name": "GP38_nairovirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048530": {"description": "FAM171, N-terminal", "go_ids": [], "go_terms": [], "name": "FAM171_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048531": {"description": "Protein ea8.5-like", "go_ids": [], "go_terms": [], "name": "ea8_5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048532": {"description": "Protein ea8.5-like superfamily", "go_ids": [], "go_terms": [], "name": "ea8_5-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR048533": {"description": "Vitamin uptake-like sensor", "go_ids": [], "go_terms": [], "name": "VUPS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048534": {"description": "Lysosomal alpha-mannosidase-like, central domain", "go_ids": [], "go_terms": [], "name": "Man2a1-like_dom", "pathway_ids": ["R-HSA-6798695", "R-MMU-8853383", "R-BTA-8853383", "R-HSA-6811438", "R-DME-975578", "R-HSA-975578", "R-HSA-8853383", "R-HSA-9694548", "R-MMU-6798695", "R-RNO-975578", "R-BTA-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-BTA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-9694548:r:Maturation of spike protein", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-BTA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR048535": {"description": "RRN6, beta-propeller", "go_ids": [], "go_terms": [], "name": "RRN6_beta-prop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048536": {"description": "RRN6, K-rich C-terminal domain", "go_ids": [], "go_terms": [], "name": "Rrn6_K-rich", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048537": {"description": "RRN6, helical bundle domain", "go_ids": [], "go_terms": [], "name": "RRN6_HB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048538": {"description": "Rrn7/TAF1B, C-terminal cyclin domain", "go_ids": [], "go_terms": [], "name": "Rrn7_cyclin_C", "pathway_ids": ["R-BTA-73762", "R-MMU-5250924", "R-MMU-73762", "R-HSA-73772", "R-RNO-73772", "R-DRE-73772", "R-HSA-427413", "R-MMU-73863", "R-RNO-5250924", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762", "R-DRE-5250924", "R-DRE-73863", "R-HSA-73863", "R-SPO-73772", "R-HSA-427359", "R-HSA-5250924", "R-MMU-73772", "R-BTA-5250924", "R-BTA-73772", "R-DME-73772", "R-SCE-73772", "R-BTA-73863"], "pathways": ["R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-DME-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73863:r:RNA Polymerase I Transcription Termination"], "type": "Domain"}, "IPR048539": {"description": "Carboxysome Shell Carbonic Anhydrase, catalytic domain", "go_ids": [], "go_terms": [], "name": "CsoSCA_cat", "pathway_ids": ["PWY-5743", "PWY-5789", "PWY-7115", "PWY-6142", "PWY-7117", "PWY-241", "PWY-5744"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-241:t:C4 photosynthetic carbon assimilation cycle, NADP-ME type", "PWY-5744:t:glyoxylate assimilation"], "type": "Domain"}, "IPR048540": {"description": "Rrn7/TAF1B, N-terminal cyclin domain", "go_ids": [], "go_terms": [], "name": "Rrn7_cyclin_N", "pathway_ids": ["R-BTA-73762", "R-MMU-5250924", "R-MMU-73762", "R-HSA-73772", "R-RNO-73772", "R-DRE-73772", "R-HSA-427413", "R-MMU-73863", "R-RNO-5250924", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762", "R-DRE-5250924", "R-DRE-73863", "R-HSA-73863", "R-SPO-73772", "R-HSA-427359", "R-HSA-5250924", "R-MMU-73772", "R-BTA-5250924", "R-BTA-73772", "R-SCE-73772", "R-BTA-73863"], "pathways": ["R-BTA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-DRE-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation", "R-DRE-5250924:r:B-WICH complex positively regulates rRNA expression", "R-DRE-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-SPO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-BTA-73772:r:RNA Polymerase I Promoter Escape", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-BTA-73863:r:RNA Polymerase I Transcription Termination"], "type": "Domain"}, "IPR048541": {"description": "Exosome complex component RRP40, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RRP40_N", "pathway_ids": ["R-BTA-450604", "R-MMU-9930044", "R-MMU-450385", "R-BTA-429958", "R-MMU-6791226", "R-HSA-9930044", "R-BTA-6791226", "R-BTA-450513", "R-BTA-450385", "R-MMU-429958", "R-DME-6791226", "R-DME-450385", "R-DME-9930044", "R-BTA-9930044", "R-HSA-450385", "R-HSA-380994", "R-MMU-450513", "R-DME-429958", "R-HSA-6791226", "R-MMU-450604", "R-DME-450513", "R-HSA-450513", "R-HSA-450604", "R-HSA-429958"], "pathways": ["R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DME-9930044:r:Nuclear RNA decay", "R-BTA-9930044:r:Nuclear RNA decay", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-DME-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Domain"}, "IPR048542": {"description": "Probable sensor domain DacZ_T", "go_ids": [], "go_terms": [], "name": "DacZ_T", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048543": {"description": "L544-like, nucleotidyltransferase domain", "go_ids": [], "go_terms": [], "name": "L544-like_NTransf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048544": {"description": "Probable sensor domain DacZ_P", "go_ids": [], "go_terms": [], "name": "DacZ_P", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048545": {"description": "L544-like, helical domain", "go_ids": [], "go_terms": [], "name": "L544-like_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048546": {"description": "Probable sensor domain DacZ_A", "go_ids": [], "go_terms": [], "name": "DacZ_A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048547": {"description": "RNA-directed RNA polymerase L, thumb ring domain, bunyaviral", "go_ids": [], "go_terms": [], "name": "L_thumb_ring_bunyavir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048548": {"description": "KRR1 small subunit processome component, second KH domain", "go_ids": [], "go_terms": [], "name": "KRR1-like_KH2", "pathway_ids": ["R-BTA-6791226", "R-DME-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR048551": {"description": "Probable sensor domain DACNV", "go_ids": [], "go_terms": [], "name": "DACNV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048552": {"description": "Probable sensor domain DACND", "go_ids": [], "go_terms": [], "name": "DACND", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048553": {"description": "Kinetochore null protein 2-like domain", "go_ids": [], "go_terms": [], "name": "Knl-2-like_dom", "pathway_ids": ["R-CEL-69273"], "pathways": ["R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition"], "type": "Domain"}, "IPR048554": {"description": "Probable sensor domain DACNG", "go_ids": [], "go_terms": [], "name": "DACNG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048555": {"description": "Probable sensor domain DACNH", "go_ids": [], "go_terms": [], "name": "DACNH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048557": {"description": "Probable sensor domain DACNK", "go_ids": [], "go_terms": [], "name": "DACNK", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048559": {"description": "Disabled homolog 1/2, sulfatide-binding motif", "go_ids": [], "go_terms": [], "name": "DAB1/2_SBM", "pathway_ids": ["R-HSA-196025", "R-MMU-8856828", "R-MMU-190873", "R-RNO-8856825", "R-RNO-196025", "R-MMU-196025", "R-MMU-8866376", "R-RNO-190873", "R-MMU-8856825", "R-HSA-8856825", "R-HSA-8856828", "R-HSA-190873", "R-RNO-8866376", "R-RNO-8856828", "R-HSA-8866376"], "pathways": ["R-HSA-196025:r:Formation of annular gap junctions", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-190873:r:Gap junction degradation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-196025:r:Formation of annular gap junctions", "R-MMU-196025:r:Formation of annular gap junctions", "R-MMU-8866376:r:Reelin signalling pathway", "R-RNO-190873:r:Gap junction degradation", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-190873:r:Gap junction degradation", "R-RNO-8866376:r:Reelin signalling pathway", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8866376:r:Reelin signalling pathway"], "type": "Conserved_site"}, "IPR048560": {"description": "Lysine-specific demethylase 6A/B-like, GATA-like", "go_ids": [], "go_terms": [], "name": "KDM6A_B-like_GATAL", "pathway_ids": ["R-HSA-2559580", "R-HSA-9772755", "R-HSA-9821002", "R-MMU-3214842", "R-HSA-9818564", "R-MMU-9818564", "R-HSA-3214842", "R-MMU-9772755", "R-MMU-2559580", "R-HSA-5617472", "R-HSA-9841922"], "pathways": ["R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-3214842:r:HDMs demethylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "type": "Domain"}, "IPR048562": {"description": "Lysine-specific demethylase 6A/B-like, C-terminal helical domain", "go_ids": [], "go_terms": [], "name": "KDM6A_B-like_C-hel", "pathway_ids": ["R-HSA-2559580", "R-HSA-9772755", "R-HSA-9821002", "R-MMU-3214842", "R-HSA-9818564", "R-MMU-9818564", "R-HSA-3214842", "R-MMU-9772755", "R-MMU-2559580", "R-CEL-3214842", "R-CEL-2559580", "R-HSA-5617472", "R-HSA-9841922"], "pathways": ["R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9821002:r:Chromatin modifications during the maternal to zygotic transition (MZT)", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-3214842:r:HDMs demethylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-3214842:r:HDMs demethylate histones", "R-CEL-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "type": "Domain"}, "IPR048563": {"description": "Peptidyl-prolyl cis-trans isomerase CYP38-like, PsbQ-like domain", "go_ids": [], "go_terms": [], "name": "CYP38_PsbQ-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048564": {"description": "Cyanate hydratase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CYNS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048565": {"description": "RRP4, S1 domain", "go_ids": [], "go_terms": [], "name": "S1_RRP4", "pathway_ids": ["R-BTA-450604", "R-MMU-9930044", "R-MMU-450385", "R-BTA-429958", "R-MMU-6791226", "R-HSA-9930044", "R-BTA-6791226", "R-BTA-450513", "R-BTA-450385", "R-CEL-450385", "R-SCE-450513", "R-MMU-429958", "R-SPO-9930044", "R-CEL-450513", "R-SCE-450385", "R-BTA-9930044", "R-HSA-450385", "R-SCE-429958", "R-HSA-380994", "R-MMU-450513", "R-SCE-6791226", "R-HSA-6791226", "R-CEL-429958", "R-MMU-450604", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-CEL-6791226", "R-HSA-429958", "R-SPO-429958", "R-SPO-6791226"], "pathways": ["R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-9930044:r:Nuclear RNA decay", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR048566": {"description": "DNA-directed RNA polymerase subunit beta', hybrid domain", "go_ids": [], "go_terms": [], "name": "RpoC_hybrid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048567": {"description": "Cyanobacterial TRADD-N associated 2, transmembrane domain", "go_ids": [], "go_terms": [], "name": "CyanoTRADDas_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048568": {"description": "RTX toxin, C-terminal repeat", "go_ids": [], "go_terms": [], "name": "RtxA_C", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR048569": {"description": "Rubicon, PI3K-binding domain", "go_ids": [], "go_terms": [], "name": "RUBC_PIKBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048570": {"description": "26S proteasome non-ATPase regulatory subunit 1/RPN2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PSMD1_RPN2_N", "pathway_ids": ["R-MMU-450408", "R-RNO-68949", "R-HSA-174178", "R-HSA-9020702", "R-RNO-8948751", "R-HSA-9604323", "R-RNO-5668541", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-8951664", "R-MMU-174154", "R-HSA-5689880", "R-HSA-9010553", "R-MMU-69017", "R-CEL-195253", "R-CEL-8941858", "R-MMU-9020702", "R-RNO-5687128", "R-RNO-382556", "R-HSA-75815", "R-MMU-8948751", "R-DME-5658442", "R-DME-8948751", "R-MMU-69481", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-CEL-1234176", "R-DDI-9929491", "R-MMU-5668541", "R-DME-2467813", "R-RNO-8854050", "R-HSA-8854050", "R-DME-5676590", "R-HSA-450408", "R-HSA-5610783", "R-RNO-450408", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-HSA-1234176", "R-RNO-4641258", "R-DDI-6798695", "R-MMU-68867", "R-DDI-174084", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-DME-4641257", "R-DME-432524", "R-MMU-9932298", "R-DME-209461", "R-MMU-1234176", "R-RNO-5689880", "R-MMU-4641258", "R-DME-75815", "R-DDI-4641258", "R-RNO-8951664", "R-RNO-9954709", "R-HSA-180534", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-CEL-8948751", "R-MMU-5687128", "R-RNO-5358346", "R-MMU-9766229", "R-DME-5358346", "R-RNO-69481", "R-RNO-6798695", "R-DDI-187577", "R-HSA-174154", "R-DME-69017", "R-RNO-9932298", "R-RNO-1234176", "R-RNO-5632684", "R-MMU-187577", "R-RNO-5676590", "R-DDI-382556", "R-HSA-68949", "R-HSA-5610785", "R-HSA-2467813", "R-DME-983168", "R-DME-187577", "R-MMU-8852276", "R-SCE-6798695", "R-RNO-174178", "R-RNO-69601", "R-CEL-9907900", "R-MMU-68949", "R-HSA-9824272", "R-MMU-174178", "R-CEL-983168", "R-MMU-349425", "R-MMU-8939236", "R-CEL-8854050", "R-HSA-9907900", "R-DME-350562", "R-DME-174084", "R-RNO-4641257", "R-DME-9907900", "R-DDI-69601", "R-CEL-75815", "R-DDI-5689603", "R-DDI-2467813", "R-DME-9929491", "R-RNO-349425", "R-MMU-9762114", "R-HSA-9762114", "R-MMU-195253", "R-DDI-5689880", "R-MMU-202424", "R-HSA-195253", "R-DME-5632684", "R-MMU-382556", "R-HSA-5610780", "R-DME-209360", "R-DDI-5687128", "R-CEL-9755511", "R-DME-6798695", "R-DDI-9907900", "R-RNO-9755511", "R-SCE-1236978", "R-RNO-75815", "R-DME-8939236", "R-MMU-1169091", "R-DME-174184", "R-DME-432626", "R-RNO-174113", "R-MMU-5607761", "R-MMU-5676590", "R-DME-8854050", "R-CEL-5689880", "R-HSA-8939902", "R-MMU-174184", "R-RNO-187577", "R-RNO-68867", "R-MMU-8939902", "R-RNO-350562", "R-DME-174178", "R-RNO-9762114", "R-DME-9932298", "R-DME-9020702", "R-RNO-69017", "R-RNO-195253", "R-CEL-9762114", "R-HSA-8939236", "R-CEL-8951664", "R-SPO-350562", "R-HSA-5358346", "R-DDI-8854050", "R-HSA-6798695", "R-DME-5689880", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-MMU-5607764", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-DME-8951664", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-HSA-202424", "R-DDI-1236978", "R-DDI-8951664", "R-DDI-5632684", "R-MMU-8951664", "R-DME-8939902", "R-RNO-174154", "R-CEL-382556", "R-CEL-5689603", "R-HSA-4641257", "R-RNO-202424", "R-MMU-9929491", "R-MMU-9929356", "R-HSA-174113", "R-DME-4608870", "R-RNO-5607761", "R-SCE-5668541", "R-RNO-9929356", "R-DDI-174154", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-HSA-69481", "R-DME-9762114", "R-CEL-4641258", "R-DDI-5658442", "R-DDI-8948751", "R-HSA-8941858", "R-HSA-5678895", "R-HSA-9755511", "R-RNO-9931269", "R-DME-202424", "R-CEL-9929491", "R-HSA-4641258", "R-RNO-8939236", "R-SPO-5689603", "R-DME-9755511", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-HSA-1169091", "R-CEL-69017", "R-HSA-4608870", "R-HSA-5658442", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-MMU-6798695", "R-DME-5610785", "R-RNO-2467813", "R-HSA-5689603", "R-DME-5607764", "R-RNO-983168", "R-DME-209406", "R-DME-2871837", "R-DME-450408", "R-DME-8941858", "R-SPO-6798695", "R-MMU-5610780", "R-HSA-187577", "R-DME-1169091", "R-DME-9954709", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-MMU-350562", "R-DDI-75815", "R-MMU-69601", "R-DME-195253", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-DME-5689603", "R-MMU-5658442", "R-RNO-8852276", "R-MMU-5689603", "R-HSA-174084", "R-DME-5607761", "R-DME-216167", "R-MMU-4608870", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-DDI-69017", "R-RNO-9907900", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-RNO-9929491", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-DME-538864", "R-SCE-9907900", "R-DDI-983168", "R-HSA-5668541", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-RNO-5607764", "R-RNO-8941858", "R-DDI-349425", "R-RNO-1169091", "R-RNO-5658442", "R-HSA-5687128", "R-HSA-69017", "R-RNO-9766229", "R-RNO-5610785", "R-MMU-983168", "R-DDI-450408", "R-DME-432395", "R-CEL-350562", "R-MMU-1236978", "R-HSA-350562", "R-DDI-174178", "R-CEL-4641257", "R-DME-68867", "R-RNO-2871837"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9020702:r:Interleukin-1 signaling", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-2467813:r:Separation of Sister Chromatids", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-4641258:r:Degradation of DVL", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-4641258:r:Degradation of DVL", "R-RNO-8951664:r:Neddylation", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9766229:r:Degradation of CDH1", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-RNO-69481:r:G2/M Checkpoints", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5632684:r:Hedgehog 'on' state", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-382556:r:ABC-family proteins mediated 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[], "name": "CusS-like_sensor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048591": {"description": "WDHD1/CFT4, helical bundle", "go_ids": [], "go_terms": [], "name": "WDHD1/CFT4_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048592": {"description": "Switch activating protein 1, N-terminal domain", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "Sap1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048593": {"description": "Acyloxyacyl hydrolase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AOAH_Saposin_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048594": {"description": "Spindle assembly abnormal protein 5, implico domain", "go_ids": [], "go_terms": [], "name": "Sas-5-like_implico", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048595": {"description": "BTB/POZ domain-containing protein KCTD1/15-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": 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"type": "Domain"}, "IPR048598": {"description": "Reovirus core-spike protein lambda-2-like, first methyltransferase domain", "go_ids": [], "go_terms": [], "name": "Reovirus_L2_MT1", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Domain"}, "IPR048600": {"description": "Spindle assembly abnormal protein 6, helical domain", "go_ids": [], "go_terms": [], "name": "Sas-6_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048601": {"description": "Reovirus core-spike protein lambda-2-like, GTase domain", "go_ids": [], "go_terms": [], "name": "Reovirus_L2_GTase", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Domain"}, "IPR048602": {"description": "Reovirus core-spike protein lambda-2-like, 7th domain", "go_ids": [], "go_terms": [], "name": "Reovirus_L2_7th", "pathway_ids": ["PWY-7375"], "pathways": ["PWY-7375:t:mRNA capping I"], "type": "Domain"}, "IPR048603": {"description": "Reovirus core-spike protein 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"R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-RNO-5620916", "R-HSA-1445148", "R-MMU-264876", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-264876:r:Insulin processing", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Domain"}, "IPR048628": {"description": "Exocyst complex component Sec3, C-terminal", "go_ids": [], "go_terms": [], "name": "Sec3_C", "pathway_ids": ["R-HSA-5620916", "R-CEL-264876", "R-MMU-5620916", "R-DME-5620916", "R-HSA-9920588", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-CEL-5620916", "R-DDI-264876", "R-SCE-264876", "R-DME-264876"], "pathways": ["R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-CEL-264876:r:Insulin processing", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing", "R-DME-264876:r:Insulin processing"], "type": "Domain"}, "IPR048629": {"description": "Inositol-tetrakisphosphate 1-kinase, preATP-grasp domain", "go_ids": [], "go_terms": [], "name": "ITPK1_preATP-grasp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048630": {"description": "Exocyst complex component Sec8, middle helical bundle", "go_ids": [], "go_terms": [], "name": "Sec8_M", "pathway_ids": ["R-RNO-264876", "R-HSA-5620916", "R-MMU-5620916", "R-RNO-5620916", "R-MMU-264876", "R-HSA-1445148", "R-HSA-264876", "R-DDI-264876", "R-SCE-264876"], "pathways": ["R-RNO-264876:r:Insulin processing", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-RNO-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-264876:r:Insulin processing", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-264876:r:Insulin processing", "R-DDI-264876:r:Insulin processing", "R-SCE-264876:r:Insulin processing"], "type": "Domain"}, "IPR048631": {"description": "Protein translocase subunit SecDF, P1 domain, N-terminal", "go_ids": [], "go_terms": [], "name": "SecD_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048632": {"description": "CsgH-like", "go_ids": [], "go_terms": [], "name": "CsgH-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048633": {"description": "Integrin alpha-X-like, third Ig-like domain", "go_ids": [], "go_terms": [], "name": "ITGAX-like_Ig_3", "pathway_ids": ["R-HSA-6798695", "R-HSA-216083", "R-RNO-216083", "R-MMU-3000178", "R-MMU-166016", "R-MMU-202733", "R-HSA-166016", "R-HSA-3000178", "R-MMU-216083", "R-MMU-6798695", "R-HSA-6785807", "R-HSA-202733"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-MMU-3000178:r:ECM proteoglycans", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Domain"}, "IPR048634": {"description": "Protein export membrane protein SecD/SecF, C-terminal", "go_ids": [], "go_terms": [], "name": "SecD_SecF_C", "pathway_ids": ["R-HSA-1222387"], "pathways": ["R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Domain"}, "IPR048635": {"description": "Transcription-repair-coupling factor, D3 domain", "go_ids": [], "go_terms": [], "name": "MFD_D3", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR048636": {"description": "Csf1, N-terminal", "go_ids": [], "go_terms": [], "name": "Csf1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048637": {"description": "Maternal embryonic leucine zipper kinase, UBA domain", "go_ids": [], "go_terms": [], "name": "MELK_UBA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048638": {"description": "Elongation factor SelB-like, third winged-helix domain", "go_ids": [], "go_terms": [], "name": "SelB-like_WHD3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048640": {"description": "MgtC-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MgtC-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048641": {"description": "Dual-specificity RNA methyltransferase RlmN, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RlmN_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048642": {"description": "Type-I-A Cascade subunit Csa5", "go_ids": [], "go_terms": [], "name": "Csa5_I-A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048643": {"description": "Intraflagellar transport protein 52, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Itf52_C", "pathway_ids": ["R-MMU-5610787", "R-MMU-5620924", "R-HSA-5610787", "R-HSA-5620924"], "pathways": ["R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR048644": {"description": "Isoamylase, C-terminal", "go_ids": [], "go_terms": [], "name": "Isoamylase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048645": {"description": "Cry1Ac-like, domain VII", "go_ids": [], "go_terms": [], "name": "Cry1Ac-like_dom-VII", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048646": {"description": "Ribosomal RNA large subunit methyltransferase M, THUMP-like domain", "go_ids": [], "go_terms": [], "name": "RlmM_THUMP-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048647": {"description": "23S rRNA (guanine(745)-N(1))-methyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "RlmA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048648": {"description": "Cytokine receptor-like factor 2-like, D2 domain", "go_ids": [], "go_terms": [], "name": "CRLF2-like_D2", "pathway_ids": ["R-MMU-8985947", "R-MMU-6785807", "R-BTA-8985947", "R-HSA-9020958", "R-MMU-1266695", "R-BTA-5673001", "R-BTA-9020958", "R-HSA-9701898", "R-HSA-8985947", "R-MMU-8983432", "R-HSA-6785807", "R-HSA-8983432", "R-BTA-8983432", "R-HSA-5673001", "R-MMU-9020958", "R-MMU-912526", "R-BTA-1266695", "R-BTA-912526", "R-HSA-912526", "R-BTA-9020558", "R-MMU-9020558", "R-BTA-6785807", "R-MMU-5673001", "R-HSA-1266695", "R-HSA-9020558"], "pathways": ["R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-BTA-8985947:r:Interleukin-9 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-9020958:r:Interleukin-21 signaling", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-BTA-8983432:r:Interleukin-15 signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-BTA-1266695:r:Interleukin-7 signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-9020558:r:Interleukin-2 signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-BTA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-9020558:r:Interleukin-2 signaling"], "type": "Domain"}, "IPR048649": {"description": "Selenocysteine-specific elongation factor, first winged helix domain", "go_ids": [], "go_terms": [], "name": "WHD_1st_3rd_SelB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048650": {"description": "Isoamylase 1-3-like, C-terminal", "go_ids": [], "go_terms": [], "name": "ISOA1-3-like_C", "pathway_ids": ["PWY-6724", "PWY-622", "PWY-2661"], "pathways": ["PWY-6724:t:starch degradation II", "PWY-622:t:starch biosynthesis", "PWY-2661:t:trehalose biosynthesis V"], "type": "Domain"}, "IPR048651": {"description": "Cytokine receptor-like factor 2-like, D1 domain", "go_ids": [], "go_terms": [], "name": "CRLF2-like_D1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048652": {"description": "Iron-regulated surface determinant protein H/B, linker domain", "go_ids": [], "go_terms": [], "name": "Isd_H_B_linker", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048653": {"description": "Alpha-L-rhamnosidase, domain D2", "go_ids": [], "go_terms": [], "name": "RhaB_D2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048654": {"description": "RHA1_ro05818, N-terminal helical domain", "go_ids": [], "go_terms": [], "name": "RHA1_ro05818_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048655": {"description": "Thiazolinyl imine reductase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Irp3-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048657": {"description": "GREB1-like, circularly permuted SF2 helicase domain", "go_ids": [], "go_terms": [], "name": "GREB1-like_cpSF2", "pathway_ids": ["R-HSA-9018519", "R-MMU-9018519"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR048658": {"description": "Invasin, domain 4", "go_ids": [], "go_terms": [], "name": "Invasin_D4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048659": {"description": "GREB1-like, second domain", "go_ids": [], "go_terms": [], "name": "GREB1-like_2nd", "pathway_ids": ["R-HSA-9018519", "R-MMU-9018519"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR048660": {"description": "Integrator complex subunit 9-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "IntS9-like_C", "pathway_ids": ["R-DME-6807505", "R-MMU-6807505", "R-HSA-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR048661": {"description": "Protein CPL1-like", "go_ids": [], "go_terms": [], "name": "CPL1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048662": {"description": "Integrator complex subunit 11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "IntS11_C", "pathway_ids": ["R-DME-6807505", "R-RNO-6807505", "R-HSA-6807505", "R-MMU-6807505", "R-DRE-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR048664": {"description": "SWI/SNF Subunit INI1, DNA binding domain", "go_ids": [], "go_terms": [], "name": "INI1_DNA-bd", "pathway_ids": ["R-GGA-8939243", "R-GGA-9933939", "R-MMU-9933946", "R-MMU-9934037", "R-XTR-3214858", "R-MMU-9933937", "R-HSA-9933939", "R-GGA-3214858", "R-XTR-8939243", "R-DRE-8939243", "R-BTA-9933946", "R-HSA-3214858", "R-HSA-9824585", "R-BTA-9933937", "R-HSA-9934037", "R-XTR-9933937", "R-BTA-9934037", "R-BTA-3214858", "R-XTR-9934037", "R-MMU-9933939", "R-MMU-3214858", "R-HSA-8939243", "R-MMU-8939243", "R-HSA-9845323", "R-HSA-9933937", "R-BTA-8939243", "R-BTA-9933939", "R-GGA-9933937", "R-HSA-9933946", "R-GGA-9934037", "R-DRE-3214858", "R-GGA-9933946"], "pathways": ["R-GGA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-GGA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-XTR-3214858:r:RMTs methylate histone arginines", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-GGA-3214858:r:RMTs methylate histone arginines", "R-XTR-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-XTR-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-XTR-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-GGA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-GGA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-GGA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex"], "type": "Domain"}, "IPR048665": {"description": "Immune inhibitor A-like metallopeptidase, VEG domain", "go_ids": [], "go_terms": [], "name": "InhA-like_VEG", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Domain"}, "IPR048666": {"description": "NADPH-dependent reductive aminase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RedAm-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048667": {"description": "Imm-5-like", "go_ids": [], "go_terms": [], "name": "Imm5-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048668": {"description": "Cytokine receptor common subunit beta, N-terminal", "go_ids": [], "go_terms": [], "name": "IL3RB_N", "pathway_ids": ["R-MMU-912526", "R-HSA-5688890", "R-HSA-5683826", "R-HSA-912526", "R-MMU-512988", "R-HSA-512988", "R-MMU-5673001", "R-HSA-5688849", "R-HSA-5673001"], "pathways": ["R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Domain"}, "IPR048669": {"description": "Histone-lysine N-methyltransferase SET1, RNA-binding domain", "go_ids": [], "go_terms": [], "name": "SET1_RBD", "pathway_ids": ["R-SCE-9772755"], "pathways": ["R-SCE-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Domain"}, "IPR048670": {"description": "Translation initiation factor 5A-like, N-terminal", "go_ids": [], "go_terms": [], "name": "IF5A-like_N", "pathway_ids": ["R-RNO-204626", "R-MMU-204626", "R-HSA-204626", "R-CEL-204626", "R-DRE-204626", "R-DDI-204626", "R-DME-204626", "R-SCE-204626", "R-GGA-204626", "R-SPO-204626", "R-BTA-204626"], "pathways": ["R-RNO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-MMU-204626:r:Hypusine synthesis from eIF5A-lysine", "R-HSA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-CEL-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DRE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DDI-204626:r:Hypusine synthesis from eIF5A-lysine", "R-DME-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SCE-204626:r:Hypusine synthesis from eIF5A-lysine", "R-GGA-204626:r:Hypusine synthesis from eIF5A-lysine", "R-SPO-204626:r:Hypusine synthesis from eIF5A-lysine", "R-BTA-204626:r:Hypusine synthesis from eIF5A-lysine"], "type": "Domain"}, "IPR048671": {"description": "RecQ-1-like, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "RecQ-1-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048672": {"description": "Nonstructural protein 13, zinc-binding domain, coronavirus", "go_ids": [], "go_terms": [], "name": "NSP13_ZBD_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "PWY-7379", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-191859", "R-HSA-9705671", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7379:t:mRNA capping II", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR048673": {"description": "Nonstructural protein 13, stalk domain, coronavirus", "go_ids": [], "go_terms": [], "name": "NSP13_stalk_CoV", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-7375", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "PWY-7379", "R-HSA-9694786", "R-HSA-9694676", "R-HSA-9694686", "R-HSA-9684325", "R-HSA-191859", "R-HSA-9705671", "R-HSA-9683439", "R-HSA-9682706", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-9694271", "R-HSA-918233", "R-HSA-9692916", "R-HSA-9682708", "R-HSA-9694301", "R-HSA-9679504"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7375:t:mRNA capping I", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-7379:t:mRNA capping II", "R-HSA-9694786:r:Transcription of SARS-CoV-2 sgRNAs", "R-HSA-9694676:r:Translation of Replicase and Assembly of the Replication Transcription Complex", "R-HSA-9694686:r:Replication of the SARS-CoV-2 genome", "R-HSA-9684325:r:Maturation of replicase proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9683439:r:Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)", "R-HSA-9682706:r:Replication of the SARS-CoV-1 genome", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation machinery", "R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-9694271:r:Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-HSA-9679504:r:Translation of Replicase and Assembly of the Replication Transcription Complex"], "type": "Domain"}, "IPR048674": {"description": "Ubiquinone biosynthesis protein COQ9, HTH domain", "go_ids": [], "go_terms": [], "name": "COQ9_HTH", "pathway_ids": ["R-HSA-2142789", "R-BTA-2142789", "R-RNO-2142789", "R-MMU-2142789", "R-DME-2142789", "R-XTR-2142789"], "pathways": ["R-HSA-2142789:r:Ubiquinol biosynthesis", "R-BTA-2142789:r:Ubiquinol biosynthesis", "R-RNO-2142789:r:Ubiquinol biosynthesis", "R-MMU-2142789:r:Ubiquinol biosynthesis", "R-DME-2142789:r:Ubiquinol biosynthesis", "R-XTR-2142789:r:Ubiquinol biosynthesis"], "type": "Domain"}, "IPR048675": {"description": "IcmR, middle region", "go_ids": [], "go_terms": [], "name": "IcmR_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048676": {"description": "COMMD9, N-terminal domain", "go_ids": [], "go_terms": [], "name": "COMMD9_N", "pathway_ids": ["R-MMU-8951664", "R-MMU-6798695", "R-HSA-8951664", "R-HSA-6798695"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR048677": {"description": "Type VI secretion system component TssM1, helical domain", "go_ids": [], "go_terms": [], "name": "TssM1_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048679": {"description": "Intercellular adhesion molecule 1/3/5, D2 domain", "go_ids": [], "go_terms": [], "name": "ICAM1_3_5_D2", "pathway_ids": ["R-MMU-198933", "R-HSA-216083", "R-RNO-216083", "R-RNO-198933", "R-CFA-216083", "R-HSA-5621575", "R-HSA-877300", "R-MMU-216083", "R-HSA-198933", "R-CFA-198933", "R-HSA-6785807", "R-HSA-6783783"], "pathways": ["R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-216083:r:Integrin cell surface interactions", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CFA-216083:r:Integrin cell surface interactions", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CFA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6783783:r:Interleukin-10 signaling"], "type": "Domain"}, "IPR048680": {"description": "Conserved oligomeric Golgi complex subunit 4, N-terminal", "go_ids": [], "go_terms": [], "name": "COG4_N", "pathway_ids": ["R-DRE-6811438", "R-BTA-6807878", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-DRE-6807878", "R-DME-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-BTA-6811440", "R-BTA-6811438", "R-MMU-6807878", "R-CEL-6811438", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DRE-6811438:r:Intra-Golgi traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-BTA-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR048681": {"description": "Intron-encoded endonuclease 1, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "I-TevI_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048682": {"description": "Conserved oligomeric Golgi complex subunit 4", "go_ids": [], "go_terms": [], "name": "COG4", "pathway_ids": ["R-DRE-6811438", "R-BTA-6807878", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-DRE-6807878", "R-DME-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-BTA-6811440", "R-BTA-6811438", "R-MMU-6807878", "R-CEL-6811438", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DRE-6811438:r:Intra-Golgi traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-BTA-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Family"}, "IPR048683": {"description": "Bacteriophage Sf6, terminase small subunit-like", "go_ids": [], "go_terms": [], "name": "Sf6_terminase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048684": {"description": "Conserved oligomeric Golgi complex subunit 4, C-terminal", "go_ids": [], "go_terms": [], "name": "COG4_C", "pathway_ids": ["R-DRE-6811438", "R-BTA-6807878", "R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-DRE-6807878", "R-DME-6807878", "R-HSA-6807878", "R-CEL-6807878", "R-BTA-6811440", "R-BTA-6811438", "R-MMU-6807878", "R-CEL-6811438", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DRE-6811438:r:Intra-Golgi traffic", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-DRE-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-BTA-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR048685": {"description": "Conserved oligomeric Golgi complex subunit 3, C-terminal", "go_ids": [], "go_terms": [], "name": "COG3_C", "pathway_ids": ["R-DME-6811440", "R-HSA-6811438", "R-MMU-6811438", "R-DDI-6807878", "R-HSA-6807878", "R-MMU-6807878", "R-DME-6807878", "R-HSA-6811440", "R-DME-6811438", "R-MMU-6811440", "R-DDI-6811438"], "pathways": ["R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DDI-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR048686": {"description": "E3 ubiquitin-protein ligase SHPRH, first helical domain", "go_ids": [], "go_terms": [], "name": "SHPRH_helical_1st", "pathway_ids": ["R-HSA-8866654", "R-MMU-8866654"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Domain"}, "IPR048687": {"description": "Uncharacterized motility-related protein HVO_2248-like", "go_ids": [], "go_terms": [], "name": "HVO_2248-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048688": {"description": "CofB-like, pilin domain", "go_ids": [], "go_terms": [], "name": "CofB-like_pilin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048689": {"description": "Envelope glycoprotein GP350, N-terminal, B domain, herpervirus", "go_ids": [], "go_terms": [], "name": "GP350_N_B_dom_herpes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048690": {"description": "CRISPR RNA silencing complex Cmr2 subunit, Zn-binding domain", "go_ids": [], "go_terms": [], "name": "Cmr2_Zn-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048692": {"description": "Envelope glycoprotein GP350, N-terminal, C domain, herpesvirus", "go_ids": [], "go_terms": [], "name": "GP350_C_dom_herpes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048693": {"description": "CRISPR RNA silencing complex Cmr2-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cmr2-like_C", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR048694": {"description": "CRISPR RNA silencing complex Cmr2 subunit, first helical domain", "go_ids": [], "go_terms": [], "name": "Cmr2_hel_dom1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048695": {"description": "E3 ubiquitin-protein ligase SHPRH, second helical domain", "go_ids": [], "go_terms": [], "name": "SHPRH_helical_2nd", "pathway_ids": ["R-HSA-8866654", "R-MMU-8866654"], "pathways": ["R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins"], "type": "Domain"}, "IPR048696": {"description": "SHQ1-like, CS domain", "go_ids": [], "go_terms": [], "name": "SHQ1-like_CS", "pathway_ids": ["R-BTA-171319", "R-HSA-171319", "R-CEL-171319", "R-DRE-171319", "R-SPO-171319", "R-SCE-171319", "R-MMU-171319"], "pathways": ["R-BTA-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-CEL-171319:r:Telomere Extension By Telomerase", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-SPO-171319:r:Telomere Extension By Telomerase", "R-SCE-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR048697": {"description": "SidC, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SidC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048698": {"description": "Envelope glycoprotein GP350, N-terminal, C domain, herpesvirus superfamily", "go_ids": [], "go_terms": [], "name": "GP350_C_dom_herpes_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR048699": {"description": "SidC, lipid-binding domain", "go_ids": [], "go_terms": [], "name": "SidC_lipid-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048700": {"description": "Envelope glycoprotein GP350, N-terminal, A domain, herpervirus superfamily", "go_ids": [], "go_terms": [], "name": "GP350_N_A_dom_herpes_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR048701": {"description": "CIP2A, N-terminal", "go_ids": [], "go_terms": [], "name": "CIP2A_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048702": {"description": "SidD, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SidD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048703": {"description": "Transposable element Tc3 transposase-like, DNA-binding HTH domain", "go_ids": [], "go_terms": [], "name": "Tnp_Tc3-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048704": {"description": "SidD, catalytic domain", "go_ids": [], "go_terms": [], "name": "SidD_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048705": {"description": "Phosphoinositide phosphatase SidF-like", "go_ids": [], "go_terms": [], "name": "SidF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048706": {"description": "Cellophane-induced 1 repeat", "go_ids": [], "go_terms": [], "name": "Cin1_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR048707": {"description": "Cellophane-induced 1 repeat superfamily", "go_ids": [], "go_terms": [], "name": "Cin1_rpt_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR048708": {"description": "Putative antitoxin VapB45-like, DNA-binding HTH domain", "go_ids": [], "go_terms": [], "name": "VapB45-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048709": {"description": "Chop1, PIN domain", "go_ids": [], "go_terms": [], "name": "Chp1_PIN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048710": {"description": "Tail knob protein gp9, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gp9_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048711": {"description": "S-adenosylmethionine-dependent methyltransferase Rv2258c-like, winged HTH domain", "go_ids": [], "go_terms": [], "name": "WHD_Rv2258c-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048712": {"description": "Tail sheath protein gp29, gp29PR", "go_ids": [], "go_terms": [], "name": "Gp29_gp29PR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048713": {"description": "Choline-binding repeat", "go_ids": [], "go_terms": [], "name": "Choline_bind_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR048714": {"description": "Transcriptional regulatory protein DpiA-like, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "DpiA-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048715": {"description": "CggR, N-terminal DNA binding domain", "go_ids": [], "go_terms": [], "name": "CggR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048716": {"description": "Protein-tyrosine-phosphatase-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Phosphatase-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048717": {"description": "SidM, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SidM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048718": {"description": "SidM, Rab1-activation domain", "go_ids": [], "go_terms": [], "name": "SidM_Rab1_act", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048719": {"description": "Complement factor I, KAZAL domain", "go_ids": [], "go_terms": [], "name": "CFAI_KAZAL", "pathway_ids": ["R-HSA-977606", "R-MMU-977606", "R-RNO-977606"], "pathways": ["R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-977606:r:Regulation of Complement cascade"], "type": "Domain"}, "IPR048720": {"description": "PROPPIN", "go_ids": [], "go_terms": [], "name": "PROPPIN", "pathway_ids": ["R-SCE-1632852", "R-HSA-381038", "R-DDI-1632852", "R-RNO-1632852", "R-GGA-1632852", "R-XTR-1632852", "R-HSA-1632852", "R-CEL-1632852", "R-DRE-1632852", "R-MMU-1632852", "R-SPO-1632852"], "pathways": ["R-SCE-1632852:r:Macroautophagy", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DDI-1632852:r:Macroautophagy", "R-RNO-1632852:r:Macroautophagy", "R-GGA-1632852:r:Macroautophagy", "R-XTR-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-DRE-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy"], "type": "Family"}, "IPR048722": {"description": "Complement factor I, FIMAC N-terminal domain", "go_ids": [], "go_terms": [], "name": "CFAI_FIMAC_N", "pathway_ids": ["R-HSA-977606", "R-MMU-977606", "R-RNO-977606"], "pathways": ["R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-977606:r:Regulation of Complement cascade", "R-RNO-977606:r:Regulation of Complement cascade"], "type": "Domain"}, "IPR048723": {"description": "26S proteasome regulatory subunit 7-like, OB domain", "go_ids": [], "go_terms": [], "name": "OB_PRS7", "pathway_ids": ["R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-HSA-174178", "R-RNO-8948751", "R-HSA-9604323", "R-MMU-8941858", "R-BTA-5689880", "R-CEL-5632684", "R-HSA-8951664", "R-HSA-5689880", "R-HSA-9010553", "R-MMU-174154", "R-MMU-69017", "R-HSA-75815", "R-MMU-9020702", "R-CEL-195253", "R-CEL-8941858", "R-BTA-9755511", "R-BTA-1234176", "R-MMU-8948751", "R-RNO-5687128", "R-RNO-382556", "R-MMU-69481", "R-BTA-350562", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-CEL-1234176", "R-BTA-75815", "R-BTA-1169091", "R-DDI-9929491", "R-MMU-5668541", "R-BTA-69481", "R-BTA-69601", "R-HSA-8854050", "R-RNO-8854050", "R-BTA-5607761", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-RNO-450408", "R-HSA-211733", "R-BTA-68867", "R-HSA-1234176", "R-RNO-4641258", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-MMU-68867", "R-DDI-174084", "R-MMU-9932298", "R-MMU-1234176", "R-RNO-5689880", "R-MMU-4641258", "R-DDI-4641258", "R-RNO-8951664", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-HSA-1236974", "R-BTA-4641257", "R-CEL-4608870", "R-CEL-8948751", "R-MMU-5687128", "R-RNO-5358346", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-RNO-69481", "R-RNO-6798695", "R-DDI-187577", "R-RNO-1234176", "R-HSA-68949", "R-HSA-5610785", "R-MMU-187577", "R-BTA-1236978", "R-HSA-2467813", "R-RNO-5632684", "R-RNO-9932298", "R-RNO-5676590", "R-BTA-195253", "R-DDI-382556", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-RNO-174178", "R-CEL-9907900", "R-RNO-69601", "R-HSA-9824272", "R-MMU-174178", "R-CEL-983168", "R-BTA-4608870", "R-BTA-5676590", "R-DDI-174178", "R-MMU-349425", "R-MMU-8939236", "R-CEL-8854050", "R-HSA-9907900", "R-BTA-2871837", "R-BTA-174154", "R-RNO-4641257", "R-DDI-69601", "R-CEL-75815", "R-DDI-5689603", "R-DDI-2467813", "R-BTA-174184", "R-MMU-9762114", "R-RNO-349425", "R-HSA-9762114", "R-MMU-195253", "R-DDI-5689880", "R-MMU-202424", "R-HSA-195253", "R-MMU-382556", "R-HSA-5610780", "R-BTA-8939236", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-187577", "R-BTA-9931269", "R-CEL-9755511", "R-DDI-9907900", "R-RNO-9755511", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-RNO-174113", "R-BTA-9929356", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-8939902", "R-CEL-5689880", "R-MMU-174184", "R-RNO-187577", "R-RNO-68867", "R-MMU-8939902", "R-RNO-350562", "R-RNO-9762114", "R-BTA-9954709", "R-RNO-69017", "R-RNO-195253", "R-HSA-8939236", "R-CEL-9762114", "R-SPO-350562", "R-HSA-5358346", "R-CEL-8951664", "R-BTA-983168", "R-HSA-6798695", "R-DDI-8854050", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-MMU-5607764", "R-BTA-5610785", "R-BTA-202424", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577", "R-HSA-5676590", "R-BTA-6798695", "R-DDI-1236978", "R-DDI-5632684", "R-DDI-8951664", "R-MMU-8951664", "R-BTA-9929491", "R-CEL-5689603", "R-CEL-382556", "R-RNO-174154", "R-HSA-4641257", "R-RNO-202424", "R-MMU-9929491", "R-HSA-174113", "R-MMU-9929356", "R-BTA-9932298", "R-BTA-9762114", "R-SCE-5668541", "R-RNO-5607761", "R-RNO-9929356", "R-DDI-174154", "R-HSA-68867", "R-MMU-9907900", "R-HSA-69481", "R-CEL-4641258", "R-BTA-174084", "R-BTA-450408", "R-DDI-5658442", "R-BTA-5687128", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DDI-349425", "R-HSA-9755511", "R-RNO-9931269", "R-HSA-4641258", "R-CEL-9929491", "R-SPO-5689603", "R-RNO-8939236", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-RNO-174184", "R-HSA-1169091", "R-CEL-69017", "R-HSA-5658442", "R-HSA-4608870", "R-MMU-2871837", "R-MMU-4641257", "R-BTA-8852276", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-RNO-2467813", "R-RNO-983168", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-SPO-6798695", "R-MMU-5610780", "R-HSA-187577", "R-DDI-983168", "R-DDI-9755511", "R-BTA-382556", "R-HSA-349425", "R-BTA-8941858", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-350562", "R-MMU-9954709", "R-DDI-75815", "R-MMU-69601", "R-HSA-2871837", "R-RNO-5689603", "R-BTA-2467813", "R-RNO-5610780", "R-RNO-5668541", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-MMU-5658442", "R-MMU-5689603", "R-RNO-8852276", "R-HSA-174084", "R-MMU-4608870", "R-HSA-5607764", "R-BTA-174178", "R-RNO-1236978", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-BTA-8948751", "R-CEL-1236978", "R-RNO-9907900", "R-RNO-4608870", "R-CEL-9954709", "R-RNO-9929491", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-SCE-9907900", "R-HSA-5668541", "R-BTA-5689603", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-HSA-5687128", "R-RNO-5607764", "R-RNO-8941858", "R-HSA-69017", "R-RNO-1169091", "R-BTA-9020702", "R-RNO-5658442", "R-RNO-9766229", "R-MMU-983168", "R-BTA-5607764", "R-RNO-5610785", "R-DDI-450408", "R-MMU-1236978", "R-CEL-350562", "R-HSA-350562", "R-HSA-202424", "R-CEL-4641257", "R-RNO-2871837"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-5689880:r:Ub-specific processing proteases", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69481:r:G2/M Checkpoints", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-RNO-8951664:r:Neddylation", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-1236974:r:ER-Phagosome pathway", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-69481:r:G2/M Checkpoints", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-9907900:r:Proteasome assembly", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-4641257:r:Degradation of AXIN", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-5689603:r:UCH proteinases", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-9907900:r:Proteasome assembly", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-69481:r:G2/M Checkpoints", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-5689603:r:UCH proteinases", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-4641258:r:Degradation of DVL", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5689603:r:UCH proteinases", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-5689603:r:UCH proteinases", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-9907900:r:Proteasome assembly", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689603:r:UCH proteinases", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-68949:r:Orc1 removal from chromatin", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-RNO-9766229:r:Degradation of CDH1", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-CEL-4641257:r:Degradation of AXIN", "R-RNO-2871837:r:FCERI mediated NF-kB activation"], "type": "Domain"}, "IPR048724": {"description": "Nuclear mitotic apparatus protein 1, N-terminal hook domain", "go_ids": [], "go_terms": [], "name": "NuMA_N_HOOK", "pathway_ids": ["R-HSA-68875", "R-MMU-68875", "R-MMU-380320", "R-HSA-380320"], "pathways": ["R-HSA-68875:r:Mitotic Prophase", "R-MMU-68875:r:Mitotic Prophase", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes"], "type": "Domain"}, "IPR048725": {"description": "Fimbrial protein MyfA/ph 6 antigen", "go_ids": [], "go_terms": [], "name": "MyfA_PsaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048727": {"description": "Ski2, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "Ski2_beta-barrel", "pathway_ids": ["R-SCE-429958"], "pathways": ["R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease"], "type": "Domain"}, "IPR048728": {"description": "Partitivirus capsid protein", "go_ids": [], "go_terms": [], "name": "CP_partitivirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048729": {"description": "Schlafen, GTPase-like domain", "go_ids": [], "go_terms": [], "name": "SLFN_GTPase-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048730": {"description": "T26-6p, C-terminal domain", "go_ids": [], "go_terms": [], "name": "T26-6p_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048731": {"description": "DNA polymerase III subunit delta', AAA+ ATPase lid domain, gammaproteobacteria", "go_ids": [], "go_terms": [], "name": "HolB_lid-gammaproteobact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048732": {"description": "Cilia- and flagella-associated protein 69", "go_ids": [], "go_terms": [], "name": "CFA69", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048733": {"description": "Cilia- and flagella-associated protein 69, ARM repeats domain", "go_ids": [], "go_terms": [], "name": "CFA69_ARM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048734": {"description": "Hyaluronate lyase, N-terminal beta-sheet domain", "go_ids": [], "go_terms": [], "name": "HL_N-beta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048735": {"description": "Ca2+-activated K+ channel Slowpoke-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Slowpoke-like_C", "pathway_ids": ["R-MMU-1300642", "R-RNO-1300642", "R-DME-1300642", "R-HSA-418457", "R-HSA-9662360", "R-HSA-1300642", "R-HSA-9667769", "R-CEL-1300642", "R-HSA-1296052", "R-DRE-1296052", "R-MMU-1296052", "R-DRE-1300642", "R-BTA-1296052", "R-RNO-1296052"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-RNO-1300642:r:Sperm Motility And Taxes", "R-DME-1300642:r:Sperm Motility And Taxes", "R-HSA-418457:r:cGMP effects", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-1300642:r:Sperm Motility And Taxes", "R-HSA-9667769:r:Acetylcholine inhibits contraction of outer hair cells", "R-CEL-1300642:r:Sperm Motility And Taxes", "R-HSA-1296052:r:Ca2+ activated K+ channels", "R-DRE-1296052:r:Ca2+ activated K+ channels", "R-MMU-1296052:r:Ca2+ activated K+ channels", "R-DRE-1300642:r:Sperm Motility And Taxes", "R-BTA-1296052:r:Ca2+ activated K+ channels", "R-RNO-1296052:r:Ca2+ activated K+ channels"], "type": "Domain"}, "IPR048736": {"description": "S-layer protein SlpA, beta-barrel", "go_ids": [], "go_terms": [], "name": "SlpA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048737": {"description": "Tubulin-like CetZ, C-terminal", "go_ids": [], "go_terms": [], "name": "CetZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048738": {"description": "Centrosomal protein CEP104, Zn finger domain", "go_ids": [], "go_terms": [], "name": "CEP104_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048739": {"description": "Centrosomal protein CEP104, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CEP104_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048740": {"description": "PurT, C-terminal", "go_ids": [], "go_terms": [], "name": "PurT_C", "pathway_ids": ["PWY-6122", "PWY-6277"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis"], "type": "Domain"}, "IPR048741": {"description": "Pus10-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Pus10-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048742": {"description": "Pus10, N-terminal, eukaryotes", "go_ids": [], "go_terms": [], "name": "Pus10_N_euk", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048743": {"description": "Inner kinetochore subunit AME1", "go_ids": [], "go_terms": [], "name": "AME1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048744": {"description": "Inner kinetochore subunit MCM16", "go_ids": [], "go_terms": [], "name": "MCM16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048745": {"description": "Toxin CdiA-like, helical domain", "go_ids": [], "go_terms": [], "name": "CdiA_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048746": {"description": "CCL2-like, lectin domain", "go_ids": [], "go_terms": [], "name": "CCL2-like_lectin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048747": {"description": "CCDC93, N-terminal domain", "go_ids": 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{"description": "Helicase SMUBP-2/HCS1, 1B domain", "go_ids": ["GO:0003723"], "go_terms": ["GO:0003723:RNA binding:F"], "name": "SMUBP-2_HCS1_1B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048763": {"description": "Sortin nexin 17/31, FERM domain, F1 lobe", "go_ids": [], "go_terms": [], "name": "SNX17-31_FERM_F1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048764": {"description": "PylC, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PylC_N", "pathway_ids": ["PWY-6994"], "pathways": ["PWY-6994:t:L-pyrrolysine biosynthesis"], "type": "Domain"}, "IPR048765": {"description": "PWWP domain-containing DNA repair factor 3A/3B/4, N-terminal", "go_ids": [], "go_terms": [], "name": "PWP3A_3B_4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048767": {"description": "Sortin nexin 17/31, FERM domain, F2 lobe", "go_ids": [], "go_terms": [], "name": "SNX17-31_FERM_F2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048768": {"description": "RNA helicase Hera-like, dimerization domain", "go_ids": [], "go_terms": [], "name": "Hera-like_DD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048769": {"description": "HepT-like domain", "go_ids": [], "go_terms": [], "name": "HepT-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048770": {"description": "Adenylyltransferase SoFic-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SoFic-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048771": {"description": "Glycoside phosphorylase, super sandwich domain", "go_ids": [], "go_terms": [], "name": "SOGP_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048772": {"description": "ATP-dependent DNA helicase Hel308-like, domain 4", "go_ids": [], "go_terms": [], "name": "Hel308-like_dom4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048773": {"description": "Glycoside phosphorylase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SOGP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048774": {"description": "Bacteriophage T7 DNA helicase/primase, N-terminal", "go_ids": [], "go_terms": [], "name": "Helic-prim_T7_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048775": {"description": "CbiG-like, linker domain", "go_ids": [], "go_terms": [], "name": "CbiG-like_linker", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048776": {"description": "Histone acetyltransferase type B catalytic subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "HAT1_C", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-MMU-3214847", "R-HSA-3214847", "R-RNO-3214847"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-RNO-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR048777": {"description": "Ciliogenesis-associated TTC17-interacting protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CATIP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048778": {"description": "NE1300-like", "go_ids": [], "go_terms": [], "name": "NE1300-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048779": {"description": "Receptor binding protein, neck domain", "go_ids": [], "go_terms": [], "name": "Caudo_bapla_RBP_neck", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048780": {"description": "Receptor-binding protein, N-terminal shoulder domain", "go_ids": [], "go_terms": [], "name": "Caudo_bapla_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048781": {"description": "Kinetochore protein Sos7, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "Sos7_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048782": {"description": "Phage tail base-plate attachment protein, C-terminal barrel domain", "go_ids": [], "go_terms": [], "name": "Caud_bapl16_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048783": {"description": "Phage tail base-plate attachment protein, C-terminal insertion domain", "go_ids": [], "go_terms": [], "name": "Caud_bapl16_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048784": {"description": "Phage tail base-plate attachment protein, N0 domain", "go_ids": [], "go_terms": [], "name": "Caud_bapl16_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048785": {"description": "NE1300-like superfamily", "go_ids": [], "go_terms": [], "name": "NE1300-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR048786": {"description": "Cation channel sperm-associated auxiliary subunit beta, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CATSPERB_N", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR048787": {"description": "SP_0191-like, C-terminal", "go_ids": [], "go_terms": [], "name": "SP_0191-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048788": {"description": "Cation channel sperm-associated auxiliary subunit beta, 2nd domain", "go_ids": [], "go_terms": [], "name": "CATSPERB_2nd", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR048789": {"description": "Cation channel sperm-associated protein subunit beta, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CATSPERB_C", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR048790": {"description": "Glycoprotein Gn, base, hantavirus", "go_ids": [], "go_terms": [], "name": "Gn-B_hanta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048791": {"description": "Glycoprotein Gc, C-terminal, bunyavirales", "go_ids": [], "go_terms": [], "name": "Gc_C_bunya", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048792": {"description": "CarD, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CarD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048793": {"description": "CapR homology domain", "go_ids": [], "go_terms": [], "name": "CapR_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048794": {"description": "Structural protein 2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SP2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048795": {"description": "PWWP domain-containing DNA repair factor 3A/3B/4, C-terminal", "go_ids": [], "go_terms": [], "name": "PWP3A_3B_4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048796": {"description": "Non-Structural protein M domain, nairovirus", "go_ids": [], "go_terms": [], "name": "NSm_dom_nairovirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048797": {"description": "Restriction endonuclease PvuRts1 I-like, N-terminal", "go_ids": [], "go_terms": [], "name": "PvuRts1I-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048798": {"description": "PutA, RHH domain", "go_ids": [], "go_terms": [], "name": "PutA_RHH", "pathway_ids": ["PWY-6922", "PWY-5737", "PWY-6853"], "pathways": ["PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-5737:t:(5R)-carbapenem carboxylate biosynthesis", "PWY-6853:t:ethene biosynthesis II (microbes)"], "type": "Domain"}, "IPR048799": {"description": "P68 RBP/TagC-like, beta-propeller", "go_ids": [], "go_terms": [], "name": "P68_RBP_TagC-like_beta-prop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048800": {"description": "Chromatin assembly factor 1 subunit Cac1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cac1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048801": {"description": "Structural glycoprotein Gn, nairovirus", "go_ids": [], "go_terms": [], "name": "Gn_nairovirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048802": {"description": "Structural protein 2, second domain", "go_ids": [], "go_terms": [], "name": "SP2_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048803": {"description": "Chaperone protein gp12", "go_ids": [], "go_terms": [], "name": "Gp12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048804": {"description": "Decoration protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DECO_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048805": {"description": "Zona-pellucida-binding protein 1/2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ZPBP1/2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048806": {"description": "Zona-pellucida-binding protein 1/2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ZPBP1/2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048807": {"description": "Putative peptidoglycan-binding domain", "go_ids": [], "go_terms": [], "name": "PG-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048808": {"description": "PG_0320-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PG_0320-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048809": {"description": "General secretion pathway protein A, peptidase C39-like domain", "go_ids": [], "go_terms": [], "name": "GspA_C39-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048810": {"description": "Baseplate wedge protein gp7, helical domain", "go_ids": [], "go_terms": [], "name": "Gp7_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048811": {"description": "Baseplate wedge protein gp7, domain V", "go_ids": [], "go_terms": [], "name": "Gp7_dom_V", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048812": {"description": "Baseplate wedge protein gp7, domain VI", "go_ids": [], "go_terms": [], "name": "Gp7_dom_VI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048813": {"description": "Major capsid protein GP7-like", "go_ids": [], "go_terms": [], "name": "GP7-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048814": {"description": "Period circadian protein homolog 1-3, PAS-A domain", "go_ids": [], "go_terms": [], "name": "Per1-3_PAS-A", "pathway_ids": ["R-HSA-9931510", "R-RNO-9932298", "R-HSA-9931530", "R-MMU-9932298", "R-HSA-9932298", "R-HSA-9931521"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex"], "type": "Domain"}, "IPR048815": {"description": "Sliding-clamp-loader large subunit, AAA+ ATPase lid domain", "go_ids": [], "go_terms": [], "name": "Gp44_lid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048816": {"description": "M17 aminopeptidase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Peptidase_M17_N_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048817": {"description": "Sliding-clamp-loader large subunit, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gp44_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048818": {"description": "BACUNI_00178-like, N-terminal domain, bacteroidetes", "go_ids": [], "go_terms": [], "name": "BACUNI_00178-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048819": {"description": "Xaa-Pro dipeptidase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PepQ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048820": {"description": "PdeA-like, PAS domain", "go_ids": [], "go_terms": [], "name": "PdeA-like_PAS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048821": {"description": "2',5'-phosphodiesterase 12-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PDE12-like_N", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978", "R-HSA-8983711", "R-BTA-8983711", "R-MMU-8983711", "R-RNO-8983711"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I", "R-HSA-8983711:r:OAS antiviral response", "R-BTA-8983711:r:OAS antiviral response", "R-MMU-8983711:r:OAS antiviral response", "R-RNO-8983711:r:OAS antiviral response"], "type": "Domain"}, "IPR048822": {"description": "PD-(D/E)XK nuclease-like domain", "go_ids": [], "go_terms": [], "name": "PDDEXK_13", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048823": {"description": "CRISPR-associated nuclease/helicase Cas3, I-F/YPEST, Cas2 domain", "go_ids": [], "go_terms": [], "name": "Cas3_I-F_Cas2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048824": {"description": "CRISPR-associated Cas3 subtype I-F/YPEST-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cas3-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048825": {"description": "Complement component C7, Kazal domain", "go_ids": [], "go_terms": [], "name": "C7_KAZAL", "pathway_ids": ["R-HSA-977606", "R-MMU-166665", "R-HSA-166665", "R-MMU-977606"], "pathways": ["R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-166665:r:Terminal pathway of complement", "R-HSA-166665:r:Terminal pathway of complement", "R-MMU-977606:r:Regulation of Complement cascade"], "type": "Domain"}, "IPR048827": {"description": "Complement component C7, FIM2 N-terminal domain", "go_ids": [], "go_terms": [], "name": "C7_FIM2_N", "pathway_ids": ["R-HSA-977606", "R-MMU-166665", "R-HSA-166665", "R-MMU-977606"], "pathways": ["R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-166665:r:Terminal pathway of complement", "R-HSA-166665:r:Terminal pathway of complement", "R-MMU-977606:r:Regulation of Complement cascade"], "type": "Domain"}, "IPR048828": {"description": "Complement component C6, KAZAL domain", "go_ids": [], "go_terms": [], "name": "C6_KAZAL", "pathway_ids": ["R-RNO-166665", "R-HSA-166665", "R-MMU-977606", "R-HSA-977606", "R-MMU-166665"], "pathways": ["R-RNO-166665:r:Terminal pathway of complement", "R-HSA-166665:r:Terminal pathway of complement", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-166665:r:Terminal pathway of complement"], "type": "Domain"}, "IPR048829": {"description": "Pre-mRNA cleavage complex 2 protein Pcf11, RFEGP repeat", "go_ids": [], "go_terms": [], "name": "PCF11_RFEG_rpt", "pathway_ids": ["R-HSA-77595", "R-MMU-72187", "R-HSA-6807505", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-77595", "R-MMU-73856", "R-HSA-73856", "R-HSA-72187", "R-HSA-9918481", "R-MMU-6807505"], "pathways": ["R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Repeat"}, "IPR048830": {"description": "Pre-mRNA cleavage complex 2 protein Pcf11, helical domain", "go_ids": [], "go_terms": [], "name": "PCF11_helical", "pathway_ids": ["R-HSA-77595", "R-MMU-72187", "R-HSA-6807505", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-77595", "R-MMU-73856", "R-HSA-73856", "R-HSA-72187", "R-HSA-9918481", "R-MMU-6807505"], "pathways": ["R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR048831": {"description": "Complement components C8A/B/C6, EGF-like domain", "go_ids": [], "go_terms": [], "name": "C8A_B_C6_EGF-like", "pathway_ids": ["R-RNO-166665", "R-HSA-166665", "R-MMU-977606", "R-HSA-977606", "R-MMU-166665"], "pathways": ["R-RNO-166665:r:Terminal pathway of complement", "R-HSA-166665:r:Terminal pathway of complement", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-166665:r:Terminal pathway of complement"], "type": "Domain"}, "IPR048832": {"description": "PCF11, charged region", "go_ids": [], "go_terms": [], "name": "PCF11_charged", "pathway_ids": ["R-HSA-77595", "R-MMU-72187", "R-HSA-6807505", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-77595", "R-MMU-73856", "R-HSA-73856", "R-HSA-72187", "R-HSA-9918481", "R-MMU-6807505"], "pathways": ["R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72187:r:mRNA 3'-end processing", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR048833": {"description": "CCA-adding enzyme, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CAA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048834": {"description": "SpaA-like, prealbumin fold domain subgroup 3", "go_ids": [], "go_terms": [], "name": "SpaA_pre-album", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048835": {"description": "Picobirnavirus capsid protein", "go_ids": [], "go_terms": [], "name": "CP_picobirnavirus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048837": {"description": "Polymerase basic protein 2, cap-binding domain", "go_ids": [], "go_terms": [], "name": "PB2_cap-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048838": {"description": "Polymerase basic protein 2, '627' domain", "go_ids": [], "go_terms": [], "name": "PB2_627_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048839": {"description": "Spermatogenesis-associated protein 2, PUB-like domain", "go_ids": [], "go_terms": [], "name": "SPATA2_PUB-like", "pathway_ids": ["R-DRE-5357905", "R-MMU-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357905", "R-RNO-5357956", "R-DRE-5357786", "R-RNO-5357905", "R-RNO-5357786", "R-MMU-5357956", "R-HSA-5357786"], "pathways": ["R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-DRE-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling"], "type": "Domain"}, "IPR048840": {"description": "Poly(A) polymerase, nucleotidyltransferase domain", "go_ids": [], "go_terms": [], "name": "PolA_pol_NTPase", "pathway_ids": ["R-MMU-9930044", "R-HSA-9930044", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-77595", "R-BTA-73856", "R-HSA-73856", "R-MMU-73856", "R-DDI-9770562", "R-HSA-72187", "R-SPO-9930044", "R-HSA-77595", "R-SPO-9770562", "R-MMU-72187", "R-BTA-9770562", "R-HSA-9918481", "R-DDI-9930044", "R-BTA-77595"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-9930044:r:Nuclear RNA decay", "R-BTA-77595:r:Processing of Intronless Pre-mRNAs"], "type": "Domain"}, "IPR048841": {"description": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2, N-terminal", "go_ids": [], "go_terms": [], "name": "PAN2_N", "pathway_ids": ["R-GGA-429947", "R-RNO-429947", "R-MMU-429947", "R-DME-429947", "R-SPO-429947", "R-HSA-429947", "R-SCE-429947"], "pathways": ["R-GGA-429947:r:Deadenylation of mRNA", "R-RNO-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-DME-429947:r:Deadenylation of mRNA", "R-SPO-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-SCE-429947:r:Deadenylation of mRNA"], "type": "Domain"}, "IPR048842": {"description": "Endo-alpha-N-acetylgalactosaminidase-like, helical bundle domain", "go_ids": [], "go_terms": [], "name": "GH101_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048843": {"description": "Complement component 5, CUB domain", "go_ids": [], "go_terms": [], "name": "C5_CUB", "pathway_ids": ["R-HSA-418594", "R-RNO-166665", "R-HSA-166665", "R-MMU-977606", "R-HSA-977606", "R-RNO-375276", "R-HSA-375276", "R-RNO-174577", "R-MMU-174577", "R-HSA-174577", "R-RNO-977606", "R-MMU-375276", "R-MMU-166665", "R-MMU-418594", "R-RNO-418594"], "pathways": ["R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-166665:r:Terminal pathway of complement", "R-HSA-166665:r:Terminal pathway of complement", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-174577:r:Activation of C3 and C5", "R-HSA-174577:r:Activation of C3 and C5", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Domain"}, "IPR048844": {"description": "Prenylated flavin chaperone LpdD-like domain", "go_ids": [], "go_terms": [], "name": "LpdD_chaperone-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048845": {"description": "tRNA (uracil(54)-C(5))/23S rRNA (uracil(747)-C(5))-methyltransferase, TRAM domain", "go_ids": [], "go_terms": [], "name": "RUMT_ARLMC_TRAM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048846": {"description": "Transcriptional repressor PaaX-like, central Cas2-like domain", "go_ids": [], "go_terms": [], "name": "PaaX-like_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048847": {"description": "Complement C4, MG1 domain", "go_ids": [], "go_terms": [], "name": "C4_MG1", "pathway_ids": ["R-RNO-166663", "R-MMU-977606", "R-HSA-9920588", "R-MMU-166663", "R-MMU-8957275", "R-RNO-977606", "R-RNO-174577", "R-RNO-381426", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-HSA-174577", "R-HSA-8957275", "R-HSA-166663", "R-HSA-381426"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-166663:r:Initial triggering of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-174577:r:Activation of C3 and C5", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR048848": {"description": "Complement component 3, CUB domain, second segment", "go_ids": [], "go_terms": [], "name": "C3_CUB2", "pathway_ids": ["R-HSA-6798695", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-375276", "R-BTA-173736", "R-HSA-9660826", "R-BTA-6798695", "R-MMU-375276", "R-MMU-8957275", "R-MMU-418594", "R-BTA-174577", "R-RNO-418594", "R-RNO-977606", "R-MMU-173736", "R-RNO-174577", "R-RNO-381426", "R-BTA-8957275", "R-HSA-418594", "R-MMU-198933", "R-BTA-418594", "R-HSA-977606", "R-RNO-8957275", "R-RNO-375276", "R-MMU-381426", "R-MMU-174577", "R-HSA-173736", "R-RNO-173736", "R-HSA-174577", "R-BTA-381426", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-HSA-381426", "R-RNO-6798695", "R-BTA-375276", "R-BTA-977606"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-173736:r:Alternative complement activation", "R-RNO-174577:r:Activation of C3 and C5", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-BTA-977606:r:Regulation of Complement cascade"], "type": "Domain"}, "IPR048849": {"description": "Endolysin PlyC", "go_ids": [], "go_terms": [], "name": "Endolysin_PlyC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048850": {"description": "BTH_I2711-like", "go_ids": [], "go_terms": [], "name": "BTH_I2711-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048851": {"description": "Stability determinant domain", "go_ids": [], "go_terms": [], "name": "PaaA2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048852": {"description": "PoNi, N-terminal domain 2", "go_ids": [], "go_terms": [], "name": "PoNi_N_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048853": {"description": "Anthrax protective antigen, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "PA_Ig-like", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Domain"}, "IPR048854": {"description": "p55, C-terminal domain", "go_ids": [], "go_terms": [], "name": "p55_CTD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048855": {"description": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha/beta/delta, EF-hand", "go_ids": [], "go_terms": [], "name": "P2R3A_B_D_EF-hand", "pathway_ids": ["R-HSA-69273", "R-HSA-113501", "R-MMU-113501", "R-MMU-69273", "R-HSA-69231", "R-MMU-69231"], "pathways": ["R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Domain"}, "IPR048856": {"description": "Major inner capsid protein P1", "go_ids": [], "go_terms": [], "name": "P1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048857": {"description": "OTU1, Ubl domain", "go_ids": [], "go_terms": [], "name": "OTU1_Ubl", "pathway_ids": ["R-DDI-5689896", "R-SCE-5689896", "R-BTA-5689896", "R-HSA-5689896", "R-SPO-5689896", "R-DRE-5689896", "R-RNO-5689896", "R-MMU-5689896", "R-DME-5689896"], "pathways": ["R-DDI-5689896:r:Ovarian tumor domain proteases", "R-SCE-5689896:r:Ovarian tumor domain proteases", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-SPO-5689896:r:Ovarian tumor domain proteases", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-DME-5689896:r:Ovarian tumor domain proteases"], "type": "Domain"}, "IPR048858": {"description": "Oligosaccharyl transferase, peripheral 1 domain", "go_ids": [], "go_terms": [], "name": "OST_P1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048859": {"description": "BTB/POZ domain-containing protein 16, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BTBD16_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048861": {"description": "Cellulose synthase subunit B-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BscB-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048862": {"description": "Stage VI sporulation protein D, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SPOCS_spoVID_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048863": {"description": "Pre-mRNA-splicing helicase BRR2-like, plug domain", "go_ids": [], "go_terms": [], "name": "BRR2_plug", "pathway_ids": ["R-HSA-72163", "R-DME-72165", "R-MMU-72165", "R-RNO-72165", "R-CEL-72165", "R-MMU-72163", "R-HSA-72165", "R-RNO-72163", "R-DME-72163", "R-CEL-72163", "R-DDI-72163", "R-SPO-72163", "R-HSA-9918481"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Domain"}, "IPR048864": {"description": "Histone H3 binding protein ORF158L-like", "go_ids": [], "go_terms": [], "name": "ORF158L-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048866": {"description": "ORC5, lid domain", "go_ids": [], "go_terms": [], "name": "ORC5_lid", "pathway_ids": ["R-DDI-68689", "R-SPO-176187", "R-HSA-68949", "R-SPO-68616", "R-MMU-68962", "R-HSA-113507", "R-MMU-68949", "R-DDI-68616", "R-HSA-68689", "R-SCE-68962", "R-DME-68616", "R-SCE-68616", "R-HSA-68616", "R-DME-68689", "R-DME-68962", "R-DDI-68962", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-HSA-68962", "R-DME-176187", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949", "R-SCE-176187", "R-HSA-176187", "R-DME-68949", "R-HSA-68867"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR048867": {"description": "Origin recognition complex subunit 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "WHD_ORC1", "pathway_ids": ["R-DDI-68689", "R-SCE-68616", "R-SPO-176187", "R-SPO-68616", "R-DDI-68962", "R-SPO-68689", "R-SCE-68689", "R-SCE-68949", "R-DDI-68949", "R-SPO-68962", "R-SPO-68949", "R-SCE-176187", "R-SCE-68962", "R-DDI-68616"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68949:r:Orc1 removal from chromatin", "R-DDI-68949:r:Orc1 removal from chromatin", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication"], "type": "Domain"}, "IPR048868": {"description": "Putative 8-oxoguanine DNA glycosylase OGG-like protein", "go_ids": [], "go_terms": [], "name": "OGG-like_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048869": {"description": "OCRL-1/2, ASH domain", "go_ids": [], "go_terms": [], "name": "OCRL-1_2_ASH", "pathway_ids": ["PWY-6368", "PWY-6363", "PWY-6362", "PWY-6364", "R-HSA-9013409", "R-MMU-8856828", "R-RNO-9013409", "R-HSA-8856828", "R-MMU-432722", "R-MMU-9013409", "R-HSA-1660514", "R-HSA-1660499", "R-RNO-1660514", "R-MMU-1660499", "R-RNO-9013423", "R-HSA-9013423", "R-MMU-9013423", "R-RNO-1660499", "R-HSA-1855204", "R-RNO-1855204", "R-HSA-1855183", "R-MMU-1660514", "R-RNO-8856828", "R-MMU-1855183", "R-MMU-1855204", "R-HSA-432722", "R-RNO-432722", "R-RNO-1855183"], "pathways": ["PWY-6368:t:3-phosphoinositide degradation", "PWY-6363:t:D-myo-inositol (1,4,5)-trisphosphate degradation", "PWY-6362:t:1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)", "PWY-6364:t:D-myo-inositol (1,3,4)-trisphosphate biosynthesis", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol"], "type": "Domain"}, "IPR048870": {"description": "Minor structural protein 5-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BppU-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048871": {"description": "Bacterial PH domain", "go_ids": [], "go_terms": [], "name": "PH_7_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048874": {"description": "Ribosomal protein bL31m, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ribosomal_bL31m_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048875": {"description": "BIRC2/3-like, UBA domain", "go_ids": [], "go_terms": [], "name": "BIRC2-3-like_UBA", "pathway_ids": ["PWY-7511", "R-HSA-111469", "R-MMU-5676594", "R-RNO-8948751", "R-CFA-5668541", "R-HSA-3769402", "R-HSA-168638", "R-HSA-5689880", "R-HSA-5676594", "R-RNO-5357905", "R-CFA-5675482", "R-MMU-8948751", "R-MMU-5357956", "R-MMU-111459", "R-CFA-5676594", "R-CFA-5689880", "R-MMU-5689880", "R-HSA-5357905", "R-MMU-9627069", "R-HSA-168927", "R-CFA-937041", "R-MMU-5668541", "R-MMU-111464", "R-CFA-168638", "R-HSA-937041", "R-MMU-168638", "R-HSA-9627069", "R-CFA-5357956", "R-HSA-111463", "R-MMU-111465", "R-RNO-111464", "R-RNO-8948747", "R-HSA-111459", "R-MMU-3769402", "R-MMU-5357786", "R-MMU-111463", "R-HSA-8948747", "R-HSA-5675482", "R-MMU-5675482", "R-CFA-5357786", "R-HSA-111464", "R-MMU-8948747", "R-RNO-111459", "R-RNO-111469", "R-HSA-5357786", "R-MMU-111469", "R-HSA-5213460", "R-HSA-5668541", "R-HSA-5357956", "R-RNO-9627069", "R-MMU-5357905", "R-HSA-111465", "R-HSA-8948751", "R-RNO-5357956", "R-RNO-5675482", "R-RNO-3769402", "R-RNO-111463", "R-RNO-5357786", "R-CFA-5357905", "R-MMU-937041"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-CFA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-CFA-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-CFA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-RNO-8948747:r:Regulation of PTEN localization", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-CFA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-MMU-8948747:r:Regulation of PTEN localization", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-111463:r:SMAC (DIABLO) binds to IAPs", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1"], "type": "Domain"}, "IPR048876": {"description": "TypA/BipA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BipA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048877": {"description": "Oxalate Biosynthetic Component A, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ObcA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048878": {"description": "Oxalate biosynthetic component 1, cap domain", "go_ids": [], "go_terms": [], "name": "Obc1_cap", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048879": {"description": "Oxalate biosynthetic component 1, C-terminal", "go_ids": [], "go_terms": [], "name": "Obc1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048883": {"description": "Nucleoporin Nup188, N-terminal subdomain III", "go_ids": [], "go_terms": [], "name": "Nup188_N-subdom_III", "pathway_ids": ["R-XTR-4615885", "R-HSA-180910", "R-SPO-3371453", "R-HSA-9705671", "R-XTR-9615933", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-SPO-159227", "R-SPO-159231", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-XTR-159236", "R-SPO-9615933", "R-DME-4085377", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-9615933", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-MMU-4085377", "R-MMU-4551638", "R-HSA-3371453", "R-HSA-165054", "R-DME-4615885", "R-HSA-4570464", "R-XTR-170822", "R-SPO-4085377", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-XTR-191859", "R-DME-3371453", "R-HSA-168276", "R-SPO-159236", "R-HSA-168271", "R-HSA-6784531", "R-DME-4551638", "R-MMU-3301854", "R-XTR-3371453", "R-DME-159227", "R-HSA-4085377", "R-HSA-168325", "R-XTR-4085377", "R-XTR-3301854", "R-HSA-9609690", "R-MMU-170822", "R-MMU-159236", "R-HSA-159231", "R-DME-159230", "R-DME-9615933", "R-HSA-3232142", "R-HSA-3301854", "R-DME-3301854", "R-HSA-9615933", "R-MMU-159227", "R-SPO-4570464", "R-HSA-5619107", "R-SPO-4551638", "R-HSA-159236", "R-MMU-3108214", "R-XTR-3108214", "R-HSA-180746"], "pathways": ["R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-XTR-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-XTR-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-XTR-191859:r:snRNP Assembly", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-XTR-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-XTR-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Domain"}, "IPR048884": {"description": "Nucleoporin Nup120, helical domain, fungal", "go_ids": [], "go_terms": [], "name": "Nup120_helical", "pathway_ids": ["R-SPO-3371453", "R-SPO-4570464", "R-SPO-159236", "R-SPO-159227", "R-SPO-159231", "R-SPO-4551638", "R-SPO-9615933", "R-SPO-4085377"], "pathways": ["R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins"], "type": "Domain"}, "IPR048886": {"description": "Bridging integrator 2, C-terminal tail", "go_ids": [], "go_terms": [], "name": "Bin2_C", "pathway_ids": ["R-MMU-6798695", "R-HSA-9673768", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR048887": {"description": "NtrZ-like", "go_ids": [], "go_terms": [], "name": "NtrZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048888": {"description": "BibA adhesin-like, stalk domain", "go_ids": [], "go_terms": [], "name": "BibA_stalk", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048889": {"description": "NSUN5/RCM1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NSUN5_RCM1_N", "pathway_ids": ["PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668"], "pathways": ["PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis"], "type": "Domain"}, "IPR048890": {"description": "BH1974-like, central domain", "go_ids": [], "go_terms": [], "name": "BH1974-like_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048891": {"description": "Non-structural protein 3, zinc-binding domain", "go_ids": [], "go_terms": [], "name": "nsP3_ZBD", "pathway_ids": ["PWY-7045", "PWY-5381", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-7706", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-5316", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-7529", "PWY-8076", "PWY-5479", "PWY-6322", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-7342", "PWY-7904", "PWY-6736", "PWY-6998", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-7888", "PWY-5773", "PWY-7155", "PWY-7719", "PWY-7076", "PWY-7737", "PWY-8106", "PWY-6682", "PWY-8104", "PWY-7419", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-6545", "PWY-8379", "PWY-6749", "PWY-7668", "PWY-8179", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-7769", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-7127", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6626", "PWY-6286", "PWY-6581", "PWY-4202", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-7184", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-2681", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-7185", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7210", "PWY-7729", "PWY-7198", "PWY-7375", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-8117", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-7375:t:mRNA capping I", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR048892": {"description": "Nrd1/Seb1, domain 2", "go_ids": [], "go_terms": [], "name": "Nrd1_Seb1_dom2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048893": {"description": "Nuclear pore complex-interacting protein B13-like, MII repeat", "go_ids": [], "go_terms": [], "name": "NPB13-like_MII_rpt", "pathway_ids": ["R-HSA-9692916"], "pathways": ["R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Repeat"}, "IPR048894": {"description": "Infectious salmon anemia virus nucleoprotein, C-terminal", "go_ids": [], "go_terms": [], "name": "NCAP_ISAV_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048895": {"description": "MJ0694-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MJ0694-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048896": {"description": "Nop5/56-related, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Nop5_56-rel_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048897": {"description": "Nucleolar protein 11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Nol11_C", "pathway_ids": ["R-BTA-6791226", "R-MMU-6791226", "R-HSA-6790901", "R-HSA-6791226"], "pathways": ["R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR048898": {"description": "60S ribosomal export protein NMD3, OB-fold domain", "go_ids": [], "go_terms": [], "name": "OB_NMD3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048899": {"description": "60S ribosomal export protein NMD3, SH3 domain", "go_ids": [], "go_terms": [], "name": "NMD_SH3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048900": {"description": "NLR family member X1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NLRX1_C", "pathway_ids": ["R-HSA-9758274", "R-MMU-936440", "R-RNO-9758274", "R-HSA-936440", "R-MMU-9758274", "R-HSA-168928", "R-RNO-936440"], "pathways": ["R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling"], "type": "Domain"}, "IPR048901": {"description": "Cysteine methyltransferase effector NleE/OspZ", "go_ids": [], "go_terms": [], "name": "NleE/OspZ", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR048903": {"description": "Phosphoribosyl-dephospho-CoA transferase MdcG, N-terminal", "go_ids": [], "go_terms": [], "name": "MdcG_N", "pathway_ids": ["PWY-5796"], "pathways": ["PWY-5796:t:malonate decarboxylase activation"], "type": "Domain"}, "IPR048904": {"description": "Mcp40H-20-like, sensor", "go_ids": [], "go_terms": [], "name": "Mcp40H-20-like_sensor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048905": {"description": "Major capsid protein 1/2, C-terminal", "go_ids": [], "go_terms": [], "name": "Vir_MCP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048907": {"description": "MCM, C-terminal domain", "go_ids": [], "go_terms": [], "name": "WHD_MCM_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048909": {"description": "6-fold beta flower protein", "go_ids": [], "go_terms": [], "name": "Bflower_3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048910": {"description": "5-fold beta-flower protein", "go_ids": [], "go_terms": [], "name": "Bflower_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048911": {"description": "4-fold beta flower domain", "go_ids": [], "go_terms": [], "name": "Bflower", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048912": {"description": "Beta-galactosidase 1-like , first all-beta domain", "go_ids": [], "go_terms": [], "name": "BetaGal1-like_ABD1", "pathway_ids": ["PWY-6807", "R-DDI-9840310", "R-MMU-9840310", "R-HSA-2024101", "R-HSA-9953111", "R-HSA-6798695", "R-DDI-6798695", "R-RNO-9840310", "R-HSA-9840310", "R-HSA-2022857", "R-RNO-2022857", "R-MMU-2022857", "R-RNO-2024101", "R-MMU-4085001", "R-MMU-2024101", "R-HSA-4341670", "R-MMU-6798695", "R-DDI-2022857", "R-HSA-4085001", "R-DDI-2024101", "R-HSA-2206308"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-9953111:r:MPS IV - Morquio syndrome B (CS/DS degradation)", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-2022857:r:Keratan sulfate degradation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-RNO-2024101:r:CS/DS degradation", "R-MMU-4085001:r:Sialic acid metabolism", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-4341670:r:Defective NEU1 causes sialidosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-2022857:r:Keratan sulfate degradation", "R-HSA-4085001:r:Sialic acid metabolism", "R-DDI-2024101:r:CS/DS degradation", "R-HSA-2206308:r:MPS IV - Morquio syndrome B (Keratin metabolism)"], "type": "Domain"}, "IPR048913": {"description": "Beta-galactosidase, galactose-binding domain", "go_ids": [], "go_terms": [], "name": "BetaGal_gal-bd", "pathway_ids": ["PWY-6807", "R-DDI-9840310", "R-MMU-9840310", "R-HSA-2024101", "R-HSA-9953111", "R-HSA-6798695", "R-DDI-6798695", "R-RNO-9840310", "R-HSA-9840310", "R-HSA-2022857", "R-RNO-2022857", "R-MMU-2022857", "R-RNO-2024101", "R-MMU-4085001", "R-MMU-2024101", "R-HSA-4341670", "R-MMU-6798695", "R-DDI-2022857", "R-HSA-4085001", "R-DDI-2024101", "R-HSA-2206308"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)", "R-DDI-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-2024101:r:CS/DS degradation", "R-HSA-9953111:r:MPS IV - Morquio syndrome B (CS/DS degradation)", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-2022857:r:Keratan sulfate degradation", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-2022857:r:Keratan sulfate degradation", "R-RNO-2024101:r:CS/DS degradation", "R-MMU-4085001:r:Sialic acid metabolism", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-4341670:r:Defective NEU1 causes sialidosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-2022857:r:Keratan sulfate degradation", "R-HSA-4085001:r:Sialic acid metabolism", "R-DDI-2024101:r:CS/DS degradation", "R-HSA-2206308:r:MPS IV - Morquio syndrome B (Keratin metabolism)"], "type": "Domain"}, "IPR048915": {"description": "Bacterial Death-like domain 3", "go_ids": [], "go_terms": [], "name": "bDLD3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048916": {"description": "Bacterial Death-like domain 2", "go_ids": [], "go_terms": [], "name": "bDLD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048917": {"description": "Bacterial Death-like domain 1", "go_ids": [], "go_terms": [], "name": "bDLD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048918": {"description": "Single-stranded-DNA-specific exonuclease RecJ, C-terminal domain, deinococcus", "go_ids": [], "go_terms": [], "name": "RecJ_C_deino", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048919": {"description": "Bride of doubletime-like, TPR domain", "go_ids": [], "go_terms": [], "name": "Bdbt-like_TPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048920": {"description": "Meiotic recombination protein REC102", "go_ids": [], "go_terms": [], "name": "REC102", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048921": {"description": "Bc2l-C, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Bc2l-C_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048922": {"description": "Bbp16", "go_ids": [], "go_terms": [], "name": "Bbp16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048923": {"description": "Restriction endonuclease, type II, NgoFVII, C-terminal B3-like DNA-binding domain", "go_ids": [], "go_terms": [], "name": "RE_NgoFVII_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048924": {"description": "BAHCC1-like, Tudor domain", "go_ids": [], "go_terms": [], "name": "BAHCC1-like_Tudor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048925": {"description": "Rod-determining factor A", "go_ids": [], "go_terms": [], "name": "RdfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048926": {"description": "Bag6, BAG-similar domain", "go_ids": [], "go_terms": [], "name": "Bag6_BAGS", "pathway_ids": ["R-HSA-9609523"], "pathways": ["R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "type": "Domain"}, "IPR048928": {"description": "AvrRps4 family type III secretion system effector", "go_ids": [], "go_terms": [], "name": "AvrRps4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048929": {"description": "DNA-binding protein Rap1, C-terminal, S.pombe", "go_ids": [], "go_terms": [], "name": "Rap1_C_Sp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048930": {"description": "Bacterial transglutaminase-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Bact_transglu_N_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048931": {"description": "Selenocysteine-specific elongation factor, second winged helix domain", "go_ids": [], "go_terms": [], "name": "WHD_2nd_SelB_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048932": {"description": "Alpha-rhamnosidase-like, N-terminal domain, bacteroidetes", "go_ids": [], "go_terms": [], "name": "Rhamnosid-like_N_bacteroidetes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048933": {"description": "Metallo-beta-lactamase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "B_lactamase-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048934": {"description": "Acidianus two-tailed virus, ORF273 protein", "go_ids": [], "go_terms": [], "name": "ATV_ORF273", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048935": {"description": "Avirulence protein ATR1, WY-domain", "go_ids": [], "go_terms": [], "name": "ATR1_WY-dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048936": {"description": "MvdD-like, pre-ATP grasp domain", "go_ids": [], "go_terms": [], "name": "MvdD-like_ATPgrasp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048937": {"description": "F1F0-ATP synthase delta subunit, C-terminal domain, metazoan", "go_ids": [], "go_terms": [], "name": "ATPD_C_metazoa", "pathway_ids": ["R-BTA-163210", "R-RNO-163210", "R-RNO-8949613", "R-BTA-8949613", "R-MMU-8949613", "R-HSA-8949613", "R-HSA-163210", "R-MMU-163210"], "pathways": ["R-BTA-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-8949613:r:Cristae formation", "R-BTA-8949613:r:Cristae formation", "R-MMU-8949613:r:Cristae formation", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling"], "type": "Domain"}, "IPR048938": {"description": "F1F0-ATP synthase subunit delta, C-terminal domain, fungi", "go_ids": [], "go_terms": [], "name": "ATPD_C_fung", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048939": {"description": "Autophagy protein ATG5, UblA domain", "go_ids": [], "go_terms": [], "name": "ATG5_UblA", "pathway_ids": ["R-HSA-8934903", "R-DDI-1632852", "R-MMU-8934903", "R-RNO-8934903", "R-RNO-5205685", "R-CEL-8934903", "R-BTA-5205685", "R-CEL-1632852", "R-MMU-1632852", "R-HSA-936440", "R-CEL-5205685", "R-MMU-5205685", "R-BTA-1632852", "R-SCE-1632852", "R-SPO-8934903", "R-RNO-1632852", "R-BTA-8934903", "R-SCE-8934903", "R-HSA-1632852", "R-DME-1632852", "R-HSA-5205685", "R-SPO-1632852"], "pathways": ["R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DDI-1632852:r:Macroautophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-1632852:r:Macroautophagy", "R-SCE-1632852:r:Macroautophagy", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-1632852:r:Macroautophagy", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-1632852:r:Macroautophagy"], "type": "Domain"}, "IPR048940": {"description": "Autophagy protein ATG5, alpha-helical bundle region", "go_ids": [], "go_terms": [], "name": "ATG5_HBR", "pathway_ids": ["R-HSA-8934903", "R-DDI-1632852", "R-MMU-8934903", "R-RNO-8934903", "R-RNO-5205685", "R-CEL-8934903", "R-BTA-5205685", "R-CEL-1632852", "R-MMU-1632852", "R-HSA-936440", "R-CEL-5205685", "R-MMU-5205685", "R-BTA-1632852", "R-SCE-1632852", "R-SPO-8934903", "R-RNO-1632852", "R-BTA-8934903", "R-SCE-8934903", "R-HSA-1632852", "R-DME-1632852", "R-HSA-5205685", "R-SPO-1632852"], "pathways": ["R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-DDI-1632852:r:Macroautophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-1632852:r:Macroautophagy", "R-MMU-1632852:r:Macroautophagy", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-1632852:r:Macroautophagy", "R-SCE-1632852:r:Macroautophagy", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-RNO-1632852:r:Macroautophagy", "R-BTA-8934903:r:Receptor Mediated Mitophagy", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-HSA-1632852:r:Macroautophagy", "R-DME-1632852:r:Macroautophagy", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-SPO-1632852:r:Macroautophagy"], "type": "Domain"}, "IPR048941": {"description": "ATG1-like, MIT domain 2", "go_ids": [], "go_terms": [], "name": "ATG1-like_MIT2", "pathway_ids": ["R-SCE-1632852", "R-HSA-8934903", "R-SPO-8934903", "R-MMU-8934903", "R-HSA-5357905", "R-MMU-8876198", "R-HSA-8854214", "R-CEL-8934903", "R-MMU-5357905", "R-SCE-8934903", "R-MMU-1632852", "R-HSA-1632852", "R-CEL-1632852", "R-SPO-1632852", "R-HSA-8876198", "R-CEL-8854214", "R-SPO-8876198", "R-MMU-8854214"], "pathways": ["R-SCE-1632852:r:Macroautophagy", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-SPO-8934903:r:Receptor Mediated Mitophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8854214:r:TBC/RABGAPs", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-SCE-8934903:r:Receptor Mediated Mitophagy", "R-MMU-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-CEL-1632852:r:Macroautophagy", "R-SPO-1632852:r:Macroautophagy", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8854214:r:TBC/RABGAPs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8854214:r:TBC/RABGAPs"], "type": "Domain"}, "IPR048942": {"description": "Apoptosis-stimulating of p53 protein 2-like, RA domain", "go_ids": [], "go_terms": [], "name": "ASPP2-like_RA", "pathway_ids": ["R-MMU-6804759", "R-HSA-6803204", "R-HSA-6803205", "R-HSA-6803211", "R-HSA-139915", "R-HSA-6804759"], "pathways": ["R-MMU-6804759:r:Regulation of TP53 Activity through Association with Co-factors", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-6803211:r:TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-139915:r:Activation of PUMA and translocation to mitochondria", "R-HSA-6804759:r:Regulation of TP53 Activity through Association with Co-factors"], "type": "Domain"}, "IPR048943": {"description": "RAD51D, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RAD51D_N", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704331", "R-BTA-5693568", "R-BTA-5693616", "R-HSA-9704646", "R-BTA-5685942", "R-BTA-5693579", "R-MMU-5693568", "R-HSA-5693554", "R-HSA-9709603", "R-MMU-5685942", "R-HSA-5693579", "R-MMU-5693616", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-6796648", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR048945": {"description": "Ras association domain-containing protein 8/10, RA domain", "go_ids": [], "go_terms": [], "name": "RASSF8/10_RA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048946": {"description": "Q4D059-like", "go_ids": [], "go_terms": [], "name": "Q4D059-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048949": {"description": "Primosomal protein N'-like, winged helix", "go_ids": [], "go_terms": [], "name": "WHD_PriA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048950": {"description": "Ppx/GppA phosphatase, C-terminal", "go_ids": [], "go_terms": [], "name": "Ppx_GppA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048951": {"description": "Exopolyphosphatase, C-terminal", "go_ids": [], "go_terms": [], "name": "Ppx_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048952": {"description": "Asparagine--tRNA ligase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AsnRS_N", "pathway_ids": ["R-HSA-379716"], "pathways": ["R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR048953": {"description": "Protection of telomeres protein 1, C-terminal insertion domain", "go_ids": [], "go_terms": [], "name": "POT1_C_insert", "pathway_ids": ["R-GGA-174417", "R-MMU-174430", "R-MMU-110330", "R-HSA-171306", "R-HSA-174414", "R-GGA-174437", "R-MMU-2559586", "R-GGA-174411", "R-MMU-174417", "R-HSA-174430", "R-HSA-110328", "R-GGA-174414", "R-GGA-174430", "R-HSA-1221632", "R-HSA-174411", "R-MMU-110331", "R-MMU-9670095", "R-MMU-171319", "R-HSA-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-GGA-418124", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-GGA-171319", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-GGA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-GGA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-GGA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-GGA-174414:r:Processive synthesis on the C-strand of the telomere", "R-GGA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-GGA-418124:r:Telomere maintenance", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-GGA-171319:r:Telomere Extension By Telomerase", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Domain"}, "IPR048954": {"description": "PorZ, N-terminal beta-propeller domain", "go_ids": [], "go_terms": [], "name": "PorZ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048955": {"description": "Cip1-like, core domain", "go_ids": [], "go_terms": [], "name": "Cip1-like_core", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048956": {"description": "Selenocysteine-specific elongation factor, domain III, archaea", "go_ids": [], "go_terms": [], "name": "SelB_III_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048957": {"description": "ARMC9, LIS1 homology motif", "go_ids": [], "go_terms": [], "name": "ARMC9_LisH", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR048958": {"description": "Polysaccharide lyase 14", "go_ids": [], "go_terms": [], "name": "Polysacc_lyase_14", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048959": {"description": "LisH domain-containing protein ARMC9, ARM repeat domain", "go_ids": [], "go_terms": [], "name": "ARMC9_ARM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048960": {"description": "POLQ-like, helical domain", "go_ids": [], "go_terms": [], "name": "POLQ-like_helical", "pathway_ids": ["R-MMU-5685939", "R-HSA-5685939"], "pathways": ["R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)"], "type": "Domain"}, "IPR048962": {"description": "E3 ubiquitin-protein ligase ARIH1-like, UBA-like domain", "go_ids": [], "go_terms": [], "name": "ARIH1-like_UBL", "pathway_ids": ["R-BTA-9909505", "R-DDI-9833482", "R-MMU-9909505", "R-HSA-9833482", "R-CEL-9833482", "R-HSA-1169408", "R-MMU-1169408", "R-HSA-9909505", "R-DDI-983168", "R-MMU-9833482", "R-CEL-9909505", "R-CEL-1169408", "R-DDI-9909505", "R-SPO-983168", "R-SCE-9646399", "R-HSA-9833110", "R-SCE-983168", "R-BTA-1169408", "R-SCE-5205685", "R-BTA-9833482", "R-DDI-1169408"], "pathways": ["R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DDI-9833482:r:PKR-mediated signaling", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9833482:r:PKR-mediated signaling", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9833482:r:PKR-mediated signaling", "R-CEL-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-9646399:r:Aggrephagy", "R-HSA-9833110:r:RSV-host interactions", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-1169408:r:ISG15 antiviral mechanism", "R-SCE-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-BTA-9833482:r:PKR-mediated signaling", "R-DDI-1169408:r:ISG15 antiviral mechanism"], "type": "Domain"}, "IPR048963": {"description": "Arginine dihydrolase ArgZ/ArgE-like, C-terminal, second subdomain", "go_ids": [], "go_terms": [], "name": "ArgZ/ArgE-like_C_2nd", "pathway_ids": ["PWY-4981"], "pathways": ["PWY-4981:t:L-proline biosynthesis II (from arginine)"], "type": "Domain"}, "IPR048964": {"description": "Arginine dihydrolase ArgZ/ArgE-like, C-terminal, first subdomain", "go_ids": [], "go_terms": [], "name": "ArgZ/ArgE-like_C_1st", "pathway_ids": ["PWY-4981"], "pathways": ["PWY-4981:t:L-proline biosynthesis II (from arginine)"], "type": "Domain"}, "IPR048965": {"description": "Activity-regulated cytoskeleton-associated protein, N-lobe", "go_ids": [], "go_terms": [], "name": "Arc_N-lobe", "pathway_ids": ["R-HSA-9031628"], "pathways": ["R-HSA-9031628:r:NGF-stimulated transcription"], "type": "Domain"}, "IPR048966": {"description": "RNA helicase aquarius, beta-barrel", "go_ids": [], "go_terms": [], "name": "Aquarius_b-barrel", "pathway_ids": ["R-HSA-72163", "R-MMU-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-72163", "R-HSA-6782210", "R-MMU-6782210", "R-HSA-6782135", "R-HSA-9918481", "R-HSA-6781823"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex"], "type": "Domain"}, "IPR048967": {"description": "RNA helicase aquarius, insertion domain", "go_ids": [], "go_terms": [], "name": "Aquarius_insert", "pathway_ids": ["R-HSA-72163", "R-MMU-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-72163", "R-HSA-6782210", "R-MMU-6782210", "R-HSA-6782135", "R-HSA-9918481", "R-HSA-6781823"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex"], "type": "Domain"}, "IPR048968": {"description": "Anaphase-promoting complex subunit 5, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Apc5_N", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-HSA-2467813", "R-RNO-2559582", "R-MMU-174154", "R-MMU-2467813", "R-MMU-179409", "R-MMU-69017", "R-RNO-174178", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-RNO-176407", "R-MMU-174048", "R-HSA-141430", "R-RNO-174154", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-HSA-68867", "R-HSA-176412", "R-RNO-141430", "R-MMU-176408", "R-MMU-176409", "R-MMU-68867", "R-HSA-176409", "R-RNO-176412", "R-HSA-9687136", "R-RNO-174048", "R-MMU-2559582", "R-HSA-983168", "R-MMU-176412", "R-MMU-176407", "R-RNO-179409", "R-RNO-174184", "R-MMU-174184", "R-RNO-68867", "R-MMU-141430", "R-RNO-176408", "R-HSA-69017", "R-RNO-174084", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-RNO-2467813", "R-RNO-983168", "R-RNO-69017", "R-HSA-174154"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-RNO-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-RNO-176412:r:Phosphorylation of the APC/C", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin"], "type": "Domain"}, "IPR048969": {"description": "FACT complex subunit SPT16, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FACT_SPT16_C", "pathway_ids": ["R-CEL-75955", "R-SPO-674695", "R-MMU-6796648", "R-DME-674695", "R-HSA-167238", "R-HSA-167243", "R-DME-6796648", "R-SCE-6804756", "R-MMU-6804756", "R-DME-75955", "R-HSA-6796648", "R-MMU-75955", "R-SPO-6804756", "R-MMU-112382", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-6804756", "R-HSA-75955", "R-CEL-112382", "R-HSA-167152", "R-SCE-674695", "R-CEL-6804756", "R-SPO-6796648", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382", "R-SCE-6796648"], "pathways": ["R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes"], "type": "Domain"}, "IPR048970": {"description": "Single-stranded DNA binding protein Ssb-like, OB fold", "go_ids": [], "go_terms": [], "name": "OB_Ssb-like", "pathway_ids": ["R-HSA-6807505", "R-RNO-6807505", "R-XTR-6807505", "R-BTA-6807505", "R-MMU-6807505"], "pathways": ["R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR048971": {"description": "Anaphase-promoting complex subunit 1, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Apc1_3rd", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-SPO-176408", "R-HSA-2467813", "R-MMU-2467813", "R-MMU-174154", "R-MMU-179409", "R-MMU-69017", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-DDI-176409", "R-DDI-2559582", "R-DDI-2467813", "R-SPO-983168", "R-DDI-176412", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-68867", "R-MMU-176409", "R-DDI-174084", "R-HSA-176409", "R-SPO-2559582", "R-HSA-9687136", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-SPO-179409", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-MMU-141430", "R-DDI-174184", "R-HSA-69017", "R-DDI-141430", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-DDI-174178", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Domain"}, "IPR048972": {"description": "PMI1/PMIR1-2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PMI1_PMIR1-2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048973": {"description": "Bacteriophage PM2 P3 protein-like", "go_ids": [], "go_terms": [], "name": "PM2_P3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048974": {"description": "PlyCA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PlyCA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048975": {"description": "Apoptotic protease-activating factor 1, winged-helix domain", "go_ids": [], "go_terms": [], "name": "WHD_APAF1", "pathway_ids": ["R-HSA-111459", "R-HSA-6798695", "R-DRE-111459", "R-HSA-6803207", "R-HSA-111464", "R-HSA-111458", "R-MMU-111458", "R-DRE-111458", "R-RNO-111459", "R-HSA-8953750", "R-DRE-9627069", "R-MMU-111459", "R-RNO-111458", "R-MMU-9627069", "R-DRE-6798695", "R-RNO-9627069", "R-MMU-6798695", "R-HSA-9627069", "R-HSA-111463", "R-RNO-6798695"], "pathways": ["R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-111458:r:Formation of apoptosome", "R-MMU-111458:r:Formation of apoptosome", "R-DRE-111458:r:Formation of apoptosome", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-111458:r:Formation of apoptosome", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR048976": {"description": "PKMT, C-terminal winged helix domain", "go_ids": [], "go_terms": [], "name": "WHD_PKMT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048977": {"description": "SsfX3-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SsfX3-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048978": {"description": "AP-5 complex subunit beta-1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AP5B1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048979": {"description": "AP5B1, middle domain", "go_ids": [], "go_terms": [], "name": "AP5B1_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048980": {"description": "AP-5 complex subunit beta-1, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "AP5B1_barrel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048981": {"description": "AP5B1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AP5B1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048982": {"description": "PirA-like", "go_ids": [], "go_terms": [], "name": "PirA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048983": {"description": "Alpha-11 giardin, fourth annexin domain", "go_ids": [], "go_terms": [], "name": "Alpha11G_Annexin_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048984": {"description": "Secreted effector protein PipB2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PipB2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048985": {"description": "FACT complex subunit SSRP1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SSRP1_C", "pathway_ids": ["R-MMU-6796648", "R-RNO-674695", "R-HSA-167238", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-MMU-6804756", "R-HSA-6796648", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-HSA-167200", "R-HSA-6804756", "R-HSA-167290", "R-RNO-112382", "R-HSA-167152", "R-HSA-75955", "R-RNO-6804756", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR048986": {"description": "Protein D-63", "go_ids": [], "go_terms": [], "name": "SSV1_D-63", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR048987": {"description": "PIN domain associated with the TPR-GreAB-C-PIN system", "go_ids": [], "go_terms": [], "name": "PIN-TPR-GreABC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048988": {"description": "Signal transducer and activator of transcription, linker domain", "go_ids": [], "go_terms": [], "name": "STAT_linker", "pathway_ids": ["R-RNO-6785807", "R-DME-877300", "R-HSA-9942503", "R-HSA-9020958", "R-HSA-9833482", "R-MMU-1266695", "R-RNO-9020558", "R-DME-209405", "R-HSA-198745", "R-CEL-9701898", "R-RNO-512988", "R-RNO-8854691", "R-CEL-6783783", "R-SSC-8983432", "R-MMU-9020958", "R-MMU-201556", "R-SSC-9020933", "R-SSC-9833482", "R-BTA-9020558", "R-DME-210693", "R-CEL-9008059", "R-DME-3249367", "R-HSA-9616222", "R-HSA-512988", "R-MMU-909733", "R-DME-1251985", "R-HSA-9701898", "R-MMU-186763", "R-HSA-9027283", "R-HSA-2586552", "R-HSA-8984722", "R-HSA-1170546", "R-DME-8985947", "R-HSA-452723", "R-HSA-8983432", "R-BTA-8983432", "R-RNO-9020958", "R-HSA-9008059", "R-DME-1059683", "R-HSA-909733", "R-DME-6783783", 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"R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DME-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-SSC-1266695:r:Interleukin-7 signaling", "R-BTA-8985947:r:Interleukin-9 signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-CEL-3249367:r:STAT6-mediated induction of chemokines", "R-MMU-9020956:r:Interleukin-27 signaling", "R-SSC-912694:r:Regulation of IFNA/IFNB signaling", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-BTA-1266695:r:Interleukin-7 signaling", "R-MMU-9020591:r:Interleukin-12 signaling", "R-CEL-877300:r:Interferon gamma signaling", "R-HSA-8849474:r:PTK6 Activates STAT3", "R-HSA-877312:r:Regulation of IFNG signaling", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-8983432:r:Interleukin-15 signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-210671:r:Transcriptional repression by nuclear factors", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-MMU-877312:r:Regulation of IFNG signaling", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-SSC-1059683:r:Interleukin-6 signaling", "R-RNO-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-CEL-9020956:r:Interleukin-27 signaling", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-8849474:r:PTK6 Activates STAT3", "R-DME-8983432:r:Interleukin-15 signaling", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-201556:r:Signaling by ALK", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-CEL-877312:r:Regulation of IFNG signaling", "R-DME-186763:r:Downstream signal transduction", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-RNO-6783783:r:Interleukin-10 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", 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"R-BTA-8854691:r:Interleukin-20 family signaling", "R-SSC-8849474:r:PTK6 Activates STAT3", "R-CEL-186763:r:Downstream signal transduction", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-SSC-201556:r:Signaling by ALK", "R-RNO-1059683:r:Interleukin-6 signaling", "R-SSC-6783783:r:Interleukin-10 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-8854691:r:Interleukin-20 family signaling", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-BTA-186763:r:Downstream signal transduction", "R-SSC-8985947:r:Interleukin-9 signaling", "R-DME-8984722:r:Interleukin-35 Signalling", "R-RNO-186763:r:Downstream signal transduction", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-CEL-8985947:r:Interleukin-9 signaling", "R-SSC-9020958:r:Interleukin-21 signaling", "R-DME-9020956:r:Interleukin-27 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-9020591:r:Interleukin-12 signaling", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-9645135:r:STAT5 Activation", "R-RNO-1266695:r:Interleukin-7 signaling", "R-CEL-1059683:r:Interleukin-6 signaling", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-SSC-9008059:r:Interleukin-37 signaling", "R-SSC-9020956:r:Interleukin-27 signaling", "R-DME-909733:r:Interferon alpha/beta signaling", "R-BTA-9020958:r:Interleukin-21 signaling", "R-DME-9008059:r:Interleukin-37 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-DME-877312:r:Regulation of IFNG signaling", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-DME-8854691:r:Interleukin-20 family signaling", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DME-9020591:r:Interleukin-12 signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-CEL-8984722:r:Interleukin-35 Signalling", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-SSC-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-8875791:r:MET activates STAT3", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-DME-201556:r:Signaling by ALK", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-9008059:r:Interleukin-37 signaling", "R-RNO-9008059:r:Interleukin-37 signaling"], "type": "Domain"}, "IPR048990": {"description": "Metalloprotease StcE, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "StcE_b-sandwich", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048991": {"description": "PHA01746-like domain", "go_ids": [], "go_terms": [], "name": "PHA01746-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048992": {"description": "Stereocilin, LRR domain", "go_ids": [], "go_terms": [], "name": "Stereocilin_LRR", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR048993": {"description": "FACT complex subunit SSRP1-like, first PH domain", "go_ids": [], "go_terms": [], "name": "SSRP1-like_PH1", "pathway_ids": ["R-SPO-674695", "R-RNO-674695", "R-HSA-167238", "R-MMU-6804756", "R-DME-6796648", "R-SCE-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-DDI-674695", "R-HSA-167152", "R-DDI-6796648", "R-DDI-6804756", "R-CEL-6804756", "R-RNO-6804756", "R-SPO-6796648", "R-SCE-6796648", "R-CEL-75955", "R-MMU-6796648", "R-DME-674695", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-HSA-6804756", "R-HSA-167290", "R-RNO-112382", "R-CEL-112382", "R-HSA-75955", "R-SCE-674695", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR048994": {"description": "MTMR6-9, GRAM domain", "go_ids": [], "go_terms": [], "name": "PH-GRAM_MTMR6-9", "pathway_ids": ["R-SCE-1660516", "R-BTA-1660499", "R-HSA-1660517", "R-SCE-1660499", "R-SPO-1660499", "R-HSA-1660499", "R-SPO-1660516", "R-MMU-1660499", "R-SCE-1632852", "R-RNO-1660499", "R-SCE-1483248", "R-SCE-1660517", "R-CEL-1660499", "R-CEL-1660517", "R-HSA-1855183", "R-SPO-1660517", "R-SPO-1483248", "R-MMU-1660517", "R-SPO-1632852", "R-DRE-1660499"], "pathways": ["R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-BTA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SPO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SPO-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SCE-1632852:r:Macroautophagy", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-SCE-1483248:r:Synthesis of PIPs at the ER membrane", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-HSA-1855183:r:Synthesis of IP2, IP, and Ins in the cytosol", "R-SPO-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-1483248:r:Synthesis of PIPs at the ER membrane", "R-MMU-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-1632852:r:Macroautophagy", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Domain"}, "IPR048995": {"description": "STL11/RBM22-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "STL11/RBM22-like_N", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-SPO-72163", "R-HSA-9918481", "R-PFA-72163", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-PFA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR048996": {"description": "PGRS repeats", "go_ids": [], "go_terms": [], "name": "PGRS_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR048997": {"description": "Stonustoxin-like, helical domain", "go_ids": [], "go_terms": [], "name": "Stonustoxin-like_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048998": {"description": "STPR domain", "go_ids": [], "go_terms": [], "name": "STPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR048999": {"description": "STT3/PglB/AglB, core domain", "go_ids": [], "go_terms": [], "name": "STT3-PglB_core", "pathway_ids": ["R-MMU-9931295", "R-HSA-9931295", "R-CFA-9931295", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9926550", "R-HSA-9918432"], "pathways": ["R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Domain"}, "IPR049000": {"description": "Virulence plasmid protein pGP3-D, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PGP3-D_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049002": {"description": "Putative adhesin Stv domain", "go_ids": [], "go_terms": [], "name": "Stv", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049003": {"description": "PgaA, membrane beta barrel domain", "go_ids": [], "go_terms": [], "name": "PgaA_barrel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049004": {"description": "Scytovirin-like domain", "go_ids": [], "go_terms": [], "name": "SVN-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049005": {"description": "Major structural protein 1-like, jelly-roll domain", "go_ids": [], "go_terms": [], "name": "MSP1_barrel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049006": {"description": "Selenoprotein methionine sulfoxide reductase A, helical domain", "go_ids": [], "go_terms": [], "name": "MsrA_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049007": {"description": "Myosin A tail domain interacting protein, EF-hand domain", "go_ids": [], "go_terms": [], "name": "MTIP_EFh", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049009": {"description": "Protein arginine N-methyltransferase 3, C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "ANM3_Znf-C2H2", "pathway_ids": ["R-HSA-8876725", "R-HSA-3214858", "R-MMU-3214858", "R-RNO-3214858", "R-MMU-8876725", "R-RNO-8876725"], "pathways": ["R-HSA-8876725:r:Protein methylation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-MMU-8876725:r:Protein methylation", "R-RNO-8876725:r:Protein methylation"], "type": "Domain"}, "IPR049011": {"description": "Anamorsin, N-terminal domain, metazoan-type", "go_ids": [], "go_terms": [], "name": "Anamorsin_N_metazoan", "pathway_ids": ["R-DDI-199220", "R-DDI-75105", "R-HSA-2564830"], "pathways": ["R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Domain"}, "IPR049012": {"description": "Mutator-like transposase domain", "go_ids": [], "go_terms": [], "name": "Mutator_transp_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049013": {"description": "MxiC, C-terminal", "go_ids": [], "go_terms": [], "name": "MxiC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049014": {"description": "Transcriptional protein SWT1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SWT1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049016": {"description": "Myosin VI, lever arm", "go_ids": [], "go_terms": [], "name": "MYO6_lever", "pathway_ids": ["R-MMU-9013422", "R-HSA-9013420", "R-DME-190873", "R-MMU-190873", "R-MMU-9013420", "R-HSA-9013422", "R-HSA-399719", "R-HSA-9013418", "R-HSA-190873", "R-DME-9013422", "R-MMU-399719", "R-DME-9013418", "R-DME-9013420", "R-MMU-9013418"], "pathways": ["R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DME-190873:r:Gap junction degradation", "R-MMU-190873:r:Gap junction degradation", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-190873:r:Gap junction degradation", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle"], "type": "Domain"}, "IPR049017": {"description": "Nab2, type CCCH zinc finger 4", "go_ids": [], "go_terms": [], "name": "Nab2_Znf4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049018": {"description": "Beta-N-acetylglucosaminidase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NagA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049019": {"description": "NagJ-like, helical domain", "go_ids": [], "go_terms": [], "name": "NagJ-like_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049020": {"description": "PRKAA1/2, autoinhibitory domain", "go_ids": [], "go_terms": [], "name": "PRKAA1/2_AID", "pathway_ids": ["R-HSA-9619483", "R-MMU-380972", "R-CEL-1632852", "R-SSC-5628897", "R-MMU-1632852", "R-MMU-6804756", "R-RNO-163680", "R-HSA-5628897", "R-RNO-1632852", "R-MMU-9759194", "R-RNO-200425", "R-HSA-9759194", "R-MMU-5628897", "R-RNO-6804756", "R-SSC-9931269", "R-HSA-9613354", "R-SSC-163680", "R-SSC-6804756", "R-HSA-380972", "R-MMU-163680", "R-HSA-9931269", "R-SSC-380972", "R-MMU-200425", "R-CEL-5628897", "R-RNO-5628897", "R-RNO-9931269", "R-CEL-380972", "R-RNO-9759194", "R-HSA-2151209", "R-CEL-9759194", "R-SSC-9759194", "R-HSA-6804756", "R-HSA-200425", "R-SSC-200425", "R-RNO-380972", "R-HSA-1445148", "R-SSC-1632852", "R-HSA-1632852", "R-MMU-9931269", "R-HSA-163680"], "pathways": ["R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-CEL-1632852:r:Macroautophagy", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-1632852:r:Macroautophagy", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-RNO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-1632852:r:Macroautophagy", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9613354:r:Lipophagy", "R-SSC-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-200425:r:Carnitine shuttle", "R-CEL-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-SSC-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-200425:r:Carnitine shuttle", "R-SSC-200425:r:Carnitine shuttle", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-SSC-1632852:r:Macroautophagy", "R-HSA-1632852:r:Macroautophagy", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity"], "type": "Domain"}, "IPR049021": {"description": "AmiR, N-terminal", "go_ids": [], "go_terms": [], "name": "AmiR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049022": {"description": "Phosphoacetylglucosamine mutase AMG1, domain III", "go_ids": [], "go_terms": [], "name": "AMG1_III", "pathway_ids": ["PWY-5514", "PWY-6906", "R-SCE-446210", "R-SPO-446210", "R-SSC-446210", "R-MMU-446210", "R-HSA-446210"], "pathways": ["PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II", "PWY-6906:t:chitin derivatives degradation", "R-SCE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SPO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SSC-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine"], "type": "Domain"}, "IPR049023": {"description": "Phosphoacetylglucosamine mutase AMG1, domain II", "go_ids": [], "go_terms": [], "name": "AMG1_II", "pathway_ids": ["PWY-5514", "PWY-6906", "R-SCE-446210", "R-SPO-446210", "R-SSC-446210", "R-MMU-446210", "R-HSA-446210"], "pathways": ["PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II", "PWY-6906:t:chitin derivatives degradation", "R-SCE-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SPO-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-SSC-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-MMU-446210:r:Synthesis of UDP-N-acetyl-glucosamine", "R-HSA-446210:r:Synthesis of UDP-N-acetyl-glucosamine"], "type": "Domain"}, "IPR049024": {"description": "AIR2-like, CCHC-type 1 zinc finger 4", "go_ids": [], "go_terms": [], "name": "AIR2-like_ZnK4", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR049025": {"description": "Allograft inflammatory factor 1-like, EF-hand domain pair", "go_ids": [], "go_terms": [], "name": "AIF-1_EF_pair", "pathway_ids": ["R-HSA-9013405"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle"], "type": "Domain"}, "IPR049026": {"description": "Baseplate wedge protein gp6-like, N-terminal helical domain", "go_ids": [], "go_terms": [], "name": "Gp6-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049027": {"description": "Baseplate structural protein gp6, C-terminal domain I", "go_ids": [], "go_terms": [], "name": "Gp6_C-I", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049028": {"description": "Baseplate structural protein gp6, C-terminal domain II", "go_ids": [], "go_terms": [], "name": "gp6_C-II", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049029": {"description": "Baseplate wedge protein gp6, domain II, first", "go_ids": [], "go_terms": [], "name": "Gp6_II_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049030": {"description": "AI2M/AI1M-like, HNH endonuclease domain", "go_ids": [], "go_terms": [], "name": "AI2M-like_HNH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049031": {"description": "T2SS protein K, first SAM-like domain", "go_ids": [], "go_terms": [], "name": "T2SSK_SAM-like_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049032": {"description": "Pyrogallol hydroxytransferase large subunit-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AhtL-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049033": {"description": "Beta-agarase/YXIM esterase-like, galactose-binding domain-like", "go_ids": [], "go_terms": [], "name": "AGA-YXIM_GBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049034": {"description": "SPI-1 type 3 secretion system secretin, N0 domain", "go_ids": [], "go_terms": [], "name": "T3S_SPI-1_N0", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049035": {"description": "ATP-dependent helicase/deoxyribonuclease AddB N-terminal", "go_ids": [], "go_terms": [], "name": "AddB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049036": {"description": "AF_1763-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AF_1763-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049037": {"description": "CDP-alcohol phosphatidyltransferase AF_2299-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AF_2299-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049038": {"description": "ADAM10, cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "ADAM10_Cys-rich", "pathway_ids": ["R-HSA-1474228", "R-HSA-6798695", "R-RNO-6798695", "R-SSC-6798695", "R-SSC-381426", "R-HSA-2122948", "R-SSC-8957275", "R-BTA-1474228", "R-CEL-6798695", "R-HSA-977225", "R-HSA-2894862", "R-RNO-1474228", "R-BTA-6798695", "R-RNO-9013507", "R-SSC-1474228", "R-MMU-8957275", "R-BTA-8957275", "R-RNO-381426", "R-HSA-2979096", "R-HSA-9013700", "R-MMU-9013507", "R-HSA-2660826", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-HSA-3928665", "R-HSA-177929", "R-RNO-8957275", "R-MMU-6798695", "R-HSA-8957275", "R-HSA-2644606", "R-BTA-381426", "R-HSA-9013507", "R-HSA-2691232", "R-HSA-381426", "R-HSA-1442490", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177929:r:Signaling by EGFR", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR049039": {"description": "Regulator of microtubule dynamics protein 1-3, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "RMD1-3_a_helical_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049040": {"description": "Regulator of MON1-CCZ1 complex, N-terminal", "go_ids": [], "go_terms": [], "name": "RMC1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049041": {"description": "RalA-binding protein 1-like, Ral binding domain", "go_ids": [], "go_terms": [], "name": "RalBP1-like_Ral-bd", "pathway_ids": ["PWY-8259", "PWY-8301", "PWY-4061", "PWY-6842", "PWY-4621", "PWY-6972", "R-HSA-9013149", "R-RNO-9013149", "R-DME-9013149", "R-RNO-9013148", "R-MMU-9013148", "R-MMU-9013149", "R-DME-9013148", "R-HSA-9013148"], "pathways": ["PWY-8259:t:arsenic detoxification (plants)", "PWY-8301:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis", "PWY-4061:t:glutathione-mediated detoxification I", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-4621:t:arsenic detoxification (bacteria)", "PWY-6972:t:oleandomycin activation/inactivation", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle"], "type": "Domain"}, "IPR049042": {"description": "RNA ligase 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Rnl1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049043": {"description": "RIOX1/NO66-like, C-terminal winged helix domain", "go_ids": [], "go_terms": [], "name": "WHD_RIOX1", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-RNO-9629569", "R-MMU-9629569", "R-DDI-9629569", "R-DRE-9629569", "R-CEL-9629569", "R-DME-9629569", "R-GGA-9629569", "R-BTA-9629569", "R-HSA-9629569"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-RNO-9629569:r:Protein hydroxylation", "R-MMU-9629569:r:Protein hydroxylation", "R-DDI-9629569:r:Protein hydroxylation", "R-DRE-9629569:r:Protein hydroxylation", "R-CEL-9629569:r:Protein hydroxylation", "R-DME-9629569:r:Protein hydroxylation", "R-GGA-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Domain"}, "IPR049044": {"description": "RIF2, ASCE domain", "go_ids": [], "go_terms": [], "name": "RIF2_ASCE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049045": {"description": "RIF2, AAA+ lid domain", "go_ids": [], "go_terms": [], "name": "RIF2_lid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049046": {"description": "Non-reducing end beta-L-arabinofuranosidase-like, GH127 middle domain", "go_ids": [], "go_terms": [], "name": "Beta-AFase-like_GH127_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049047": {"description": "Recombination and repair protein UVSX-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "T4_UVSX-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049048": {"description": "REST corepressor, helical domain", "go_ids": [], "go_terms": [], "name": "REST_helical", "pathway_ids": ["R-MMU-3214815", "R-HSA-983231", "R-HSA-3214815", "R-HSA-9679191", "R-MMU-983231", "R-HSA-8943724"], "pathways": ["R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-8943724:r:Regulation of PTEN gene transcription"], "type": "Domain"}, "IPR049049": {"description": "Non-reducing end beta-L-arabinofuranosidase-like, GH127 C-terminal domain", "go_ids": [], "go_terms": [], "name": "Beta-AFase-like_GH127_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049050": {"description": "Novel STAND NTPase 3", "go_ids": [], "go_terms": [], "name": "nSTAND3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049051": {"description": "Novel STAND NTPase 2", "go_ids": [], "go_terms": [], "name": "nSTAND2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049052": {"description": "Novel STAND NTPase 1", "go_ids": [], "go_terms": [], "name": "nSTAND1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049053": {"description": "Alpha fucosidase A-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AFCA-like_C", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR049054": {"description": "Nitrile hydratase beta subunit-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CN_hydtase_beta-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049055": {"description": "NDC10, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NDC10_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049056": {"description": "NAD-glutamate dehydrogenase, helical motif 3", "go_ids": [], "go_terms": [], "name": "NAD_Glu_DH_HM3", "pathway_ids": ["PWY-6728", "PWY-5022", "PWY-7126", "PWY-8190"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-7126:t:ethene biosynthesis IV (engineered)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)"], "type": "Conserved_site"}, "IPR049057": {"description": "Infectious salmon anemia virus nucleoprotein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NCAP_ISAV_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049058": {"description": "NAD-glutamate dehydrogenase, helical motif 2", "go_ids": [], "go_terms": [], "name": "NAD_Glu_DH_HM2", "pathway_ids": ["PWY-6728", "PWY-5022", "PWY-7126", "PWY-8190"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-7126:t:ethene biosynthesis IV (engineered)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)"], "type": "Conserved_site"}, "IPR049059": {"description": "NAD-glutamate dehydrogenase, helical motif 1", "go_ids": [], "go_terms": [], "name": "NAD_Glu_DH_HM1", "pathway_ids": ["PWY-6728", "PWY-5022", "PWY-7126", "PWY-8190"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-7126:t:ethene biosynthesis IV (engineered)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)"], "type": "Conserved_site"}, "IPR049060": {"description": "Infectious salmon anemia virus nucleoprotein, helical bundle", "go_ids": [], "go_terms": [], "name": "NCAP_ISAV_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049061": {"description": "NarE-like", "go_ids": [], "go_terms": [], "name": "NarE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049062": {"description": "NAD-glutamate dehydrogenase, ACT2 domain", "go_ids": [], "go_terms": [], "name": "NAD_Glu_DH_ACT2", "pathway_ids": ["PWY-6728", "PWY-5022", "PWY-7126", "PWY-8190"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-7126:t:ethene biosynthesis IV (engineered)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)"], "type": "Domain"}, "IPR049063": {"description": "Trehalose-6-phosphate phosphatase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "T6PP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049064": {"description": "NAD-glutamate dehydrogenase, ACT3 domain", "go_ids": [], "go_terms": [], "name": "NAD_Glu_DH_ACT3", "pathway_ids": ["PWY-6728", "PWY-5022", "PWY-7126", "PWY-8190"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-7126:t:ethene biosynthesis IV (engineered)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)"], "type": "Domain"}, "IPR049065": {"description": "Nakanori-like", "go_ids": [], "go_terms": [], "name": "Nakanori", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049066": {"description": "T6SS, immunity protein Tgi2PP", "go_ids": [], "go_terms": [], "name": "T6SS_Tgi2PP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049067": {"description": "Actin homologue MreB-like, C-terminal", "go_ids": [], "go_terms": [], "name": "MreB-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049068": {"description": "Acanthaporin", "go_ids": [], "go_terms": [], "name": "Acanthaporin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049069": {"description": "MRB1590-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MRB1590-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049070": {"description": "T6SS, Immune protein Tsi2-like", "go_ids": [], "go_terms": [], "name": "T6SS_Tsi2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049071": {"description": "Mannose-6-phosphate isomerase, cupin domain", "go_ids": [], "go_terms": [], "name": "MPI_cupin_dom", "pathway_ids": ["PWY-5659", "PWY-3861", "PWY-6992", "PWY-7586", "PWY-3881", "PWY-7456"], "pathways": ["PWY-5659:t:GDP-mannose biosynthesis", "PWY-3861:t:mannitol degradation II", "PWY-6992:t:1,5-anhydrofructose degradation", "PWY-7586:t:beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation", "PWY-3881:t:mannitol biosynthesis", "PWY-7456:t:beta-(1,4)-mannan degradation"], "type": "Domain"}, "IPR049072": {"description": "Maintenance of Photosystem II under High light 2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MPH2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049073": {"description": "Type VI secretion system spike protein VgrG3-like, C-terminal", "go_ids": [], "go_terms": [], "name": "T6SS_VgrG3-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049074": {"description": "Acetyl-CoA carboxylase, BT domain", "go_ids": [], "go_terms": [], "name": "ACCA_BT", "pathway_ids": ["PWY-5743", "PWY-5966", "PWY-5789", "PWY-6679", "PWY-5744", "R-HSA-163765", "R-DDI-75105", "R-MMU-200425", "R-SPO-75105", "R-HSA-196780", "R-RNO-75105", "R-DDI-200425", "R-HSA-3371599", "R-MMU-75105", "R-MMU-196780", "R-SPO-196780", "R-RNO-196780", "R-DDI-196780", "R-HSA-200425", "R-SPO-200425", "R-RNO-200425", "R-HSA-75105", "R-SCE-196780", "R-SCE-200425", "R-HSA-2426168", "R-SCE-75105"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-6679:t:jadomycin biosynthesis", "PWY-5744:t:glyoxylate assimilation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-200425:r:Carnitine shuttle", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-196780:r:Biotin transport and metabolism", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-200425:r:Carnitine shuttle", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-196780:r:Biotin transport and metabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-DDI-196780:r:Biotin transport and metabolism", "R-HSA-200425:r:Carnitine shuttle", "R-SPO-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-196780:r:Biotin transport and metabolism", "R-SCE-200425:r:Carnitine shuttle", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR049075": {"description": "Helicase MOV-10, N-terminal", "go_ids": [], "go_terms": [], "name": "MOV-10_N", "pathway_ids": ["R-HSA-8853884", "R-HSA-9824594", "R-HSA-9839394", "R-HSA-9022692", "R-HSA-2559580", "R-HSA-8936459", "R-HSA-8943723", "R-HSA-2559585", "R-HSA-8948700", "R-HSA-5628897", "R-HSA-8934593", "R-HSA-1912408", "R-HSA-9764562", "R-HSA-9725371", "R-HSA-9768778", "R-HSA-5687128", "R-HSA-9759811", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-4086398", "R-HSA-9029569", "R-HSA-9018519"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR049076": {"description": "Acetyl-CoA carboxylase", "go_ids": ["GO:0003989"], "go_terms": ["GO:0003989:acetyl-CoA carboxylase activity:F"], "name": "ACCA", "pathway_ids": ["PWY-5743", "PWY-5966", "PWY-5789", "PWY-6679", "PWY-5744", "R-HSA-163765", "R-DDI-75105", "R-MMU-200425", "R-SPO-75105", "R-HSA-196780", "R-RNO-75105", "R-DDI-200425", "R-HSA-3371599", "R-MMU-75105", "R-MMU-196780", "R-SPO-196780", "R-RNO-196780", "R-DDI-196780", "R-HSA-200425", "R-SPO-200425", "R-RNO-200425", "R-HSA-75105", "R-SCE-196780", "R-SCE-200425", "R-HSA-2426168", "R-SCE-75105"], "pathways": ["PWY-5743:t:3-hydroxypropanoate cycle", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-5789:t:3-hydroxypropanoate/4-hydroxybutanate cycle", "PWY-6679:t:jadomycin biosynthesis", "PWY-5744:t:glyoxylate assimilation", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-200425:r:Carnitine shuttle", "R-SPO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-196780:r:Biotin transport and metabolism", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-200425:r:Carnitine shuttle", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-196780:r:Biotin transport and metabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-DDI-196780:r:Biotin transport and metabolism", "R-HSA-200425:r:Carnitine shuttle", "R-SPO-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-SCE-196780:r:Biotin transport and metabolism", "R-SCE-200425:r:Carnitine shuttle", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SCE-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Family"}, "IPR049077": {"description": "Helicase MOV-10, Ig-like domain", "go_ids": [], "go_terms": [], "name": "MOV-10_Ig-like", "pathway_ids": ["R-HSA-8853884", "R-HSA-9824594", "R-HSA-9839394", "R-HSA-9022692", "R-HSA-2559580", "R-HSA-8936459", "R-HSA-8943723", "R-HSA-2559585", "R-HSA-8948700", "R-HSA-5628897", "R-HSA-8934593", "R-HSA-1912408", "R-HSA-9764562", "R-HSA-9725371", "R-HSA-9768778", "R-HSA-5687128", "R-HSA-9759811", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-4086398", "R-HSA-9029569", "R-HSA-9018519"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-4086398:r:Ca2+ pathway", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR049078": {"description": "ESX-1 secretion system protein EccA1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "T7SS_EccA1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049079": {"description": "Helicase MOV-10, helical domain", "go_ids": [], "go_terms": [], "name": "Mov-10_helical", "pathway_ids": ["R-HSA-8853884", "R-HSA-9824594", "R-HSA-9839394", "R-HSA-9022692", "R-HSA-2559580", "R-HSA-8936459", "R-DME-9707564", "R-HSA-8943723", "R-HSA-2559585", "R-HSA-8948700", "R-HSA-5628897", "R-HSA-8934593", "R-HSA-1912408", "R-HSA-9764562", "R-HSA-9725371", "R-HSA-9768778", "R-HSA-5687128", "R-HSA-9759811", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-4086398", "R-DME-400206", "R-HSA-9029569", "R-HSA-9018519"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-4086398:r:Ca2+ pathway", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR049080": {"description": "Helicase MOV-10-like, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "MOV-10-like_beta-barrel", "pathway_ids": ["R-HSA-8853884", "R-HSA-9824594", "R-HSA-9839394", "R-HSA-9022692", "R-HSA-2559580", "R-HSA-8936459", "R-DME-9707564", "R-HSA-8943723", "R-HSA-2559585", "R-HSA-8948700", "R-HSA-5628897", "R-HSA-8934593", "R-HSA-1912408", "R-HSA-9764562", "R-HSA-9725371", "R-HSA-9768778", "R-HSA-5687128", "R-HSA-9759811", "R-HSA-9909620", "R-HSA-8986944", "R-HSA-4086398", "R-DME-400206", "R-HSA-9029569", "R-HSA-9018519", "R-HSA-5601884"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-HSA-8948700:r:Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9768778:r:Regulation of NPAS4 mRNA translation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-9759811:r:Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-4086398:r:Ca2+ pathway", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis"], "type": "Domain"}, "IPR049081": {"description": "Uncharacterized ATP-binding protein MJ1010-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MJ1010-like_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049082": {"description": "Putative T7SS secretion signal domain", "go_ids": [], "go_terms": [], "name": "T7SS_signal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049083": {"description": "TACO1/YebC-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TACO1_YebC_N", "pathway_ids": ["R-HSA-9864848"], "pathways": ["R-HSA-9864848:r:Complex IV assembly"], "type": "Domain"}, "IPR049084": {"description": "Excretory-secretory protein 2", "go_ids": [], "go_terms": [], "name": "AceES-2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049085": {"description": "Cas3 inhibitor AcrF3-like", "go_ids": [], "go_terms": [], "name": "AcrF3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049086": {"description": "TadZ-like, receiver domain", "go_ids": [], "go_terms": [], "name": "TadZ-like_ARD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049087": {"description": "TAF1C, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "TAF1C_beta-prop", "pathway_ids": ["R-HSA-73772", "R-HSA-73863", "R-MMU-5250924", "R-MMU-73762", "R-HSA-427359", "R-RNO-73772", "R-HSA-427413", "R-HSA-5250924", "R-MMU-73863", "R-MMU-73772", "R-RNO-5250924", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Domain"}, "IPR049088": {"description": "Anti-CRISPR protein Acr30-35/AcrF1", "go_ids": [], "go_terms": [], "name": "Acr30-35_AcrF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049089": {"description": "TAF1C, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TAF1C_C", "pathway_ids": ["R-HSA-73772", "R-HSA-73863", "R-MMU-5250924", "R-MMU-73762", "R-HSA-427359", "R-RNO-73772", "R-HSA-427413", "R-HSA-5250924", "R-MMU-73863", "R-MMU-73772", "R-RNO-5250924", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Domain"}, "IPR049090": {"description": "TAF1C, helical bundle domain", "go_ids": [], "go_terms": [], "name": "TAF1C_HB", "pathway_ids": ["R-HSA-73772", "R-HSA-73863", "R-MMU-5250924", "R-MMU-73762", "R-HSA-427359", "R-RNO-73772", "R-HSA-427413", "R-HSA-5250924", "R-MMU-73863", "R-MMU-73772", "R-RNO-5250924", "R-RNO-73863", "R-HSA-73762", "R-RNO-73762"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Domain"}, "IPR049092": {"description": "MIOS-like, alpha-solenoid domain", "go_ids": [], "go_terms": [], "name": "MIOS_a-sol", "pathway_ids": ["R-MMU-9639288", "R-DDI-9639288", "R-HSA-9639288", "R-DRE-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DRE-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR049093": {"description": "Msx2-interacting protein, nuclear receptor-interacting domain", "go_ids": [], "go_terms": [], "name": "MINT_RID", "pathway_ids": ["R-MMU-9013422", "R-HSA-9013422"], "pathways": ["R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle"], "type": "Domain"}, "IPR049094": {"description": "Msx2-interacting protein, RAM7 domain", "go_ids": [], "go_terms": [], "name": "MINT_RAM7", "pathway_ids": ["R-MMU-9013422", "R-HSA-9013422"], "pathways": ["R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle"], "type": "Domain"}, "IPR049095": {"description": "Msx2-interacting protein, MID domain", "go_ids": [], "go_terms": [], "name": "MINT_MID", "pathway_ids": ["R-MMU-9013422", "R-HSA-9013422"], "pathways": ["R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle"], "type": "Domain"}, "IPR049096": {"description": "Mimivirus sulfhydryl oxidase R596-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MIMI_R596-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049097": {"description": "Mitochondrial dynamics protein MID51-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MID51-like_C", "pathway_ids": ["R-DRE-9937383", "R-HSA-9937383", "R-RNO-9937383", "R-MMU-9937383"], "pathways": ["R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Domain"}, "IPR049098": {"description": "Microneme protein MIC5-like domain", "go_ids": [], "go_terms": [], "name": "MIC5-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049099": {"description": "Gag polyprotein, C-terminal", "go_ids": [], "go_terms": [], "name": "Gag_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049100": {"description": "TET-Associated Glycosyltransferase", "go_ids": [], "go_terms": [], "name": "TAGT", "pathway_ids": ["R-HSA-9018519", "R-MMU-9018519"], "pathways": ["R-HSA-9018519:r:Estrogen-dependent gene expression", "R-MMU-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR049102": {"description": "Gp67, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Gp67_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049103": {"description": "Gp67, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gp67_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049104": {"description": "Tail spike protein-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tail_spike-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049105": {"description": "Emaravirus ABC_C protein", "go_ids": [], "go_terms": [], "name": "ABC_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049106": {"description": "Influenza RNA polymerase PB2, N-terminal region", "go_ids": [], "go_terms": [], "name": "Flu_PB2_N", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-168275", "R-HSA-192814", "R-HSA-192905", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Domain"}, "IPR049107": {"description": "ABC_AB protein, Emaravirus", "go_ids": [], "go_terms": [], "name": "ABC_AB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049108": {"description": "Talin, R4 domain", "go_ids": [], "go_terms": [], "name": "Talin_R4", "pathway_ids": ["R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-9656223", "R-MMU-399955", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-DDI-114608", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR049109": {"description": "Target of Nesh-SH3/FNDC1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TARSH/FNDC1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049110": {"description": "Influenza RNA polymerase PB2, second domain", "go_ids": [], "go_terms": [], "name": "Flu_PB2_2nd", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-168275", "R-HSA-192814", "R-HSA-192905", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Domain"}, "IPR049111": {"description": "Influenza RNA polymerase PB2, middle domain", "go_ids": [], "go_terms": [], "name": "Flu_PB2_middle", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-168275", "R-HSA-192814", "R-HSA-192905", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Domain"}, "IPR049112": {"description": "Tas3, C-terminal helical domain", "go_ids": [], "go_terms": [], "name": "Tas3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049113": {"description": "Polymerase basic protein 2, helical domain", "go_ids": [], "go_terms": [], "name": "PB2_helical", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-168275", "R-HSA-192814", "R-HSA-192905", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Domain"}, "IPR049114": {"description": "Influenza RNA polymerase PB2, sixth domain", "go_ids": [], "go_terms": [], "name": "Flu_PB2_6th", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-168275", "R-HSA-192814", "R-HSA-192905", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Domain"}, "IPR049115": {"description": "Influenza RNA polymerase PB2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Flu_PB2_C", "pathway_ids": ["R-HSA-168255", "R-HSA-168302", "R-HSA-168333", "R-HSA-168271", "R-HSA-168288", "R-HSA-168275", "R-HSA-192814", "R-HSA-192905", "R-HSA-168298", "R-HSA-168325", "R-HSA-168330", "R-HSA-168336", "R-HSA-192869", "R-HSA-168303", "R-HSA-192823"], "pathways": ["R-HSA-168255:r:Influenza Infection", "R-HSA-168302:r:Budding", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168288:r:Fusion of the Influenza Virion to the Host Cell Endosome", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-HSA-192814:r:vRNA Synthesis", "R-HSA-192905:r:vRNP Assembly", "R-HSA-168298:r:Release", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-HSA-168330:r:Viral RNP Complexes in the Host Cell Nucleus", "R-HSA-168336:r:Uncoating of the Influenza Virion", "R-HSA-192869:r:cRNA Synthesis", "R-HSA-168303:r:Packaging of Eight RNA Segments", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Domain"}, "IPR049116": {"description": "Tautomerase-like", "go_ids": [], "go_terms": [], "name": "Tautomerase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049117": {"description": "Pullulanase, all-beta domain", "go_ids": [], "go_terms": [], "name": "pulA_all-beta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049118": {"description": "TBP-interacting protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TBPIP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049119": {"description": "Flagellar hook-associated protein 1, D2-like domain", "go_ids": [], "go_terms": [], "name": "FlgK_D2-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049120": {"description": "Alpha-2 macroglobulin, MG2 domain", "go_ids": [], "go_terms": [], "name": "A2M_bMG2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049121": {"description": "TdIF1, C-terminal", "go_ids": ["GO:0003677"], "go_terms": ["GO:0003677:DNA binding:F"], "name": "TdIF1_C", "pathway_ids": ["R-BTA-9764725", "R-RNO-9764725", "R-HSA-9764725", "R-CEL-9764725", "R-MMU-9764725"], "pathways": ["R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription"], "type": "Domain"}, "IPR049122": {"description": "A2MG, CUB domain", "go_ids": [], "go_terms": [], "name": "A2MG_CUB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049123": {"description": "56B-like, ribbon-helix-helix", "go_ids": [], "go_terms": [], "name": "56B_RHH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049124": {"description": "TAR DNA-binding protein 43, C-terminal", "go_ids": [], "go_terms": [], "name": "TDP-43_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049125": {"description": "Fanconi-associated nuclease 1-like, winged-helix domain", "go_ids": [], "go_terms": [], "name": "FAN1-like_WH", "pathway_ids": ["R-MMU-6783310", "R-HSA-6783310", "R-DRE-6783310"], "pathways": ["R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR049126": {"description": "Fanconi-associated nuclease 1-like, TPR domain", "go_ids": [], "go_terms": [], "name": "FAN1-like_TPR", "pathway_ids": ["R-MMU-6783310", "R-HSA-6783310", "R-DRE-6783310"], "pathways": ["R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR049127": {"description": "TECR-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TECR-like_N", "pathway_ids": ["PWY-5080", "PWY-7053", "PWY-7035", "PWY-7036", "PWY-7727", "PWY-8041", "PWY-6433", "PWY-6958", "PWY-6598", "PWY-7726", "PWY-7619", "PWY-7049", "PWY-5353", "PWY-7601", "PWY-7728", "PWY-7602", "PWY-7724", "PWY-7606", "PWY-7592", "PWY-7725", "R-BTA-75876", "R-MMU-75876", "R-CEL-75876", "R-RNO-75876", "R-HSA-75876"], "pathways": ["PWY-5080:t:very long chain fatty acid biosynthesis I", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7035:t:(9Z)-tricosene biosynthesis", "PWY-7036:t:very long chain fatty acid biosynthesis II", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8041:t:ultra-long-chain fatty acid biosynthesis", "PWY-6433:t:hydroxylated fatty acid biosynthesis (plants)", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-6598:t:sciadonate biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-7619:t:juniperonate biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-7724:t:icosapentaenoate biosynthesis III (8-desaturase, mammals)", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7725:t:arachidonate biosynthesis V (8-detaturase, mammals)", "R-BTA-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-CEL-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-RNO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs"], "type": "Domain"}, "IPR049128": {"description": "Ribonucleases P/MRP subunit Pop8-like domain", "go_ids": [], "go_terms": [], "name": "Pop8-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049130": {"description": "Poxvirus, 2L, N-terminal domain", "go_ids": [], "go_terms": [], "name": "2L_N_poxvirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049131": {"description": "Paraneoplastic antigen-like protein 8A, C-terminal", "go_ids": [], "go_terms": [], "name": "PNM8A_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049133": {"description": "2B protein, soluble domain", "go_ids": [], "go_terms": [], "name": "2B_soluble", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Domain"}, "IPR049134": {"description": "Mucolipin, extracytosolic domain", "go_ids": [], "go_terms": [], "name": "MCLN_ECD", "pathway_ids": ["R-HSA-917977", "R-MMU-917977", "R-MMU-3295583", "R-HSA-3295583"], "pathways": ["R-HSA-917977:r:Transferrin endocytosis and recycling", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Domain"}, "IPR049135": {"description": "TEP1, second CUB domain", "go_ids": [], "go_terms": [], "name": "TEP1_CUB2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049136": {"description": "Phage G20C small terminase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TerS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049137": {"description": "Rudivirus, ORF117-like", "go_ids": [], "go_terms": [], "name": "ORF117-like_Rudivir", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049138": {"description": "Fanconi-associated nuclease 1, SAP subdomain, metazoa", "go_ids": [], "go_terms": [], "name": "Fan1_SAP_met", "pathway_ids": ["R-MMU-6783310", "R-HSA-6783310", "R-DRE-6783310"], "pathways": ["R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-DRE-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR049139": {"description": "Telomerase reverse transcriptase, C-terminal extension", "go_ids": [], "go_terms": [], "name": "TERT_C", "pathway_ids": ["R-MMU-201722", "R-HSA-201722", "R-HSA-9825895", "R-RNO-201722", "R-RNO-171319", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR049141": {"description": "10-bladed beta-propeller domain", "go_ids": [], "go_terms": [], "name": "10_blade", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049142": {"description": "Mechanosensitive ion channel, transmembrane helices 2/3", "go_ids": [], "go_terms": [], "name": "MS_channel_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049143": {"description": "Tertiapin", "go_ids": ["GO:0005516", "GO:0090729", "GO:0015459"], "go_terms": ["GO:0005516:calmodulin binding:F", "GO:0090729:toxin activity:F", "GO:0015459:potassium channel regulator activity:F"], "name": "Tertiapin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049144": {"description": "FAM186A/B, N-terminal", "go_ids": [], "go_terms": [], "name": "FAM186A_B_N", 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"Domain"}, "IPR049316": {"description": "Glycine dehydrogenase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GDC-P_C", "pathway_ids": ["R-DDI-6783984", "R-SPO-6783984", "R-MMU-6783984", "R-SCE-6783984", "R-HSA-6783984"], "pathways": ["R-DDI-6783984:r:Glycine degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-6783984:r:Glycine degradation", "R-SCE-6783984:r:Glycine degradation", "R-HSA-6783984:r:Glycine degradation"], "type": "Domain"}, "IPR049317": {"description": "Cyclin-D1-binding protein 1-like, N-terminal", "go_ids": [], "go_terms": [], "name": "GCIP-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049318": {"description": "Cyclin-D1-binding protein 1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "GCIP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049319": {"description": "Tip pilin GBS104-like, Ig-like domain", "go_ids": [], "go_terms": [], "name": "GBS104-like_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049320": {"description": "E3 ubiquitin-protein ligase CARP1/2, FYVE/PHD zinc finger", "go_ids": [], "go_terms": [], "name": "CARP1_2_FYVE", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-RNO-6804757", "R-HSA-6804757", "R-MMU-6804757", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168", "R-BTA-6804757"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-6804757:r:Regulation of TP53 Degradation"], "type": "Domain"}, "IPR049321": {"description": "Tyrosine 3-monooxygenase-like, ACT domain", "go_ids": [], "go_terms": [], "name": "TH_ACT", "pathway_ids": ["PWY-5049", "PWY-3581", "PWY-5394", "PWY-6133", "R-RNO-209905", "R-HSA-209905", "R-MMU-209905"], "pathways": ["PWY-5049:t:rosmarinic acid biosynthesis II", "PWY-3581:t:(S)-reticuline biosynthesis I", "PWY-5394:t:betalamic acid biosynthesis", "PWY-6133:t:(S)-reticuline biosynthesis II", "R-RNO-209905:r:Catecholamine biosynthesis", "R-HSA-209905:r:Catecholamine biosynthesis", "R-MMU-209905:r:Catecholamine biosynthesis"], "type": "Domain"}, "IPR049324": {"description": "Capsid protein, N-terminal domain, fungal virus", "go_ids": [], "go_terms": [], "name": "P2_N_fungal_virus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049325": {"description": "Thermo-DBP-RP2-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Thermo-DBP2-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049326": {"description": "Rhodopsin domain, fungi", "go_ids": [], "go_terms": [], "name": "Rhodopsin_dom_fungi", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049327": {"description": "Autotransproter heptosyltransferase TibC/BAHTCr-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TibC/BAHTCr-like_N", "pathway_ids": ["PWY-8243", "PWY-8133", "PWY-8366", "PWY-7676"], "pathways": ["PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-7676:t:Kdo8N transfer to lipid IVA"], "type": "Domain"}, "IPR049328": {"description": "Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment", "go_ids": [], "go_terms": [], "name": "TM_ErbB1", "pathway_ids": ["R-MMU-1250342", "R-RNO-1306955", "R-MMU-6785631", "R-MMU-8856828", "R-MMU-182971", "R-MMU-180336", "R-RNO-1250347", "R-HSA-180292", "R-MMU-1306955", "R-MMU-6811558", "R-HSA-8856828", "R-HSA-9665251", "R-RNO-416572", "R-HSA-2179392", "R-MMU-9009391", "R-HSA-1306955", "R-HSA-9927418", "R-RNO-9018519", "R-MMU-416572", "R-RNO-8863795", "R-HSA-8863795", "R-RNO-8847993", "R-RNO-6811558", "R-RNO-1963642", "R-MMU-9652282", "R-HSA-177929", "R-MMU-1236394", "R-HSA-9013507", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-9652282", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-9018519", "R-HSA-212718", "R-HSA-9665244", "R-HSA-182971", "R-HSA-9665686", "R-MMU-180292", "R-HSA-8847993", "R-HSA-2219530", "R-MMU-445144", "R-HSA-9609690", "R-HSA-5637810", "R-HSA-5673001", "R-HSA-9820960", "R-HSA-6811558", "R-MMU-9018519", "R-HSA-9620244", "R-RNO-1358803", "R-MMU-179812", "R-HSA-1253288", "R-MMU-1963642", "R-RNO-9652282", "R-HSA-445144", "R-MMU-1250196", "R-HSA-1257604", "R-HSA-179812", "R-HSA-8857538", "R-MMU-8863795", "R-HSA-5638303", "R-MMU-2179392", "R-HSA-416572", "R-RNO-6785631", "R-MMU-8856825", "R-HSA-1251985", "R-RNO-1257604", "R-HSA-9665737", "R-HSA-9665348", "R-HSA-1251932", "R-HSA-1250342", "R-HSA-1250347", "R-RNO-1253288", "R-HSA-9665245", "R-MMU-8847993", "R-MMU-9013507", "R-MMU-1250347", "R-HSA-8866910", "R-HSA-1236382", "R-HSA-1963642", "R-HSA-1250196", "R-HSA-9938206", "R-RNO-1251985", "R-MMU-1358803", "R-HSA-1963640", "R-HSA-9665249", "R-MMU-177929", "R-HSA-9665246", "R-RNO-1963640", "R-RNO-1250342", "R-MMU-1227986", "R-HSA-9927432", "R-RNO-1227986", "R-HSA-1227986", "R-HSA-6785631", "R-HSA-9665233", "R-MMU-1257604", "R-HSA-9665250", "R-HSA-1358803", "R-HSA-9634638", "R-HSA-180336", "R-HSA-1236394", "R-MMU-1251985", "R-HSA-9009391", "R-MMU-212718", "R-HSA-9634285", "R-HSA-8856825", "R-RNO-1236394", "R-RNO-1250196", "R-MMU-8857538", "R-MMU-1963640", "R-MMU-1253288"], "pathways": ["R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-182971:r:EGFR downregulation", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-1236394:r:Signaling by ERBB4", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-182971:r:EGFR downregulation", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9620244:r:Long-term potentiation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-MMU-177929:r:Signaling by EGFR", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-HSA-1236394:r:Signaling by ERBB4", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-1236394:r:Signaling by ERBB4", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-1253288:r:Downregulation of ERBB4 signaling"], "type": "Domain"}, "IPR049329": {"description": "Tomato mosaic virus helicase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ToMV_Hel_N", "pathway_ids": ["PWY-7045", "PWY-5381", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-7706", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-5316", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-7529", "PWY-8076", "PWY-5479", "PWY-6322", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-7342", "PWY-7904", "PWY-6736", "PWY-6998", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-7888", "PWY-5773", "PWY-7155", "PWY-7719", "PWY-7076", "PWY-7737", "PWY-8106", "PWY-6682", "PWY-8104", "PWY-7419", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-6545", "PWY-8379", "PWY-6749", "PWY-7668", "PWY-8179", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-7769", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-7127", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6626", "PWY-6286", "PWY-6581", "PWY-4202", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-7184", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-2681", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-7185", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7210", "PWY-7729", "PWY-7198", "PWY-7375", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-8117", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-7375:t:mRNA capping I", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR049330": {"description": "Topoisomerase I, zinc finger", "go_ids": [], "go_terms": [], "name": "TOP1_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049331": {"description": "DNA topoisomerase IB, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Top1B_N_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049332": {"description": "Formamidopyrimidine-DNA glycosylase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Fpg-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049333": {"description": "Type II DNA topoisomerase VI subunit A, all-beta domain", "go_ids": [], "go_terms": [], "name": "Topo_VI_alpha", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049334": {"description": "Topoisomerase V, second (HhH)2 tandem domain", "go_ids": [], "go_terms": [], "name": "Topo-V_HhH2_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049335": {"description": "Flagellar protein FlgA-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FlgA-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049336": {"description": "Tyrosine-protein kinase receptor torso, second FN3 domain", "go_ids": [], "go_terms": [], "name": "Tor_FN3_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049337": {"description": "Torsin-1A, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TOR1A_C", "pathway_ids": ["R-XTR-114608", "R-CEL-114608", "R-DRE-114608", "R-RNO-8856825", "R-CEL-8856825", "R-HSA-8856825", "R-MMU-8856825"], "pathways": ["R-XTR-114608:r:Platelet degranulation", "R-CEL-114608:r:Platelet degranulation", "R-DRE-114608:r:Platelet degranulation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis"], "type": "Domain"}, "IPR049338": {"description": "Toxofilin domain", "go_ids": [], "go_terms": [], "name": "Toxofilin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049339": {"description": "Toxofilin domain superfamily", "go_ids": [], "go_terms": [], "name": "Toxofilin_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR049340": {"description": "Outer membrane-associated lipoprotein TP0453", "go_ids": [], "go_terms": [], "name": "TP0453", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049341": {"description": "TRADD-like N-terminal domain", "go_ids": [], "go_terms": [], "name": "TRADD-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049342": {"description": "TRAF1-6, MATH domain", "go_ids": [], "go_terms": [], "name": "TRAF1-6_MATH_dom", "pathway_ids": ["R-HSA-9693928", "R-HSA-450302", "R-XTR-450321", "R-MMU-3371378", "R-HSA-937041", "R-RNO-937042", "R-SSC-975144", "R-SSC-450321", "R-DRE-937042", "R-DRE-450321", "R-MMU-975144", "R-RNO-975144", "R-HSA-205043", "R-RNO-975163", "R-HSA-9758274", "R-SSC-450302", "R-MMU-450321", "R-HSA-975163", "R-RNO-209543", "R-RNO-5689880", "R-HSA-69416", "R-MMU-69416", "R-MMU-5357905", "R-MMU-975138", "R-RNO-975138", "R-XTR-937042", "R-BTA-205043", "R-DRE-937039", "R-SSC-5689896", "R-HSA-9705671", "R-MMU-450302", "R-HSA-937042", "R-RNO-937072", "R-HSA-933542", "R-RNO-1257604", "R-MMU-9645460", "R-BTA-975871", "R-HSA-9824878", "R-RNO-450321", "R-MMU-5357956", "R-MMU-193692", "R-BTA-2871837", "R-HSA-5357905", "R-BTA-209543", "R-RNO-9645460", "R-BTA-445989", "R-MMU-5218900", "R-SSC-9020702", "R-MMU-205043", "R-SSC-975163", "R-BTA-209560", "R-BTA-975138", "R-MMU-202424", "R-XTR-166058", "R-RNO-937041", "R-XTR-450302", "R-MMU-9824878", "R-MMU-936964", "R-HSA-975871", "R-MMU-209560", "R-MMU-5675482", "R-SSC-5607764", "R-MMU-1257604", "R-XTR-9645460", "R-SSC-937041", "R-SSC-202424", "R-BTA-9645460", "R-DRE-975144", "R-HSA-933541", "R-HSA-5357956", "R-SSC-9758274", "R-BTA-1257604", "R-HSA-140534", "R-MMU-937041", "R-HSA-937039", "R-XTR-975871", "R-MMU-975871", "R-SSC-975138", "R-RNO-9020702", "R-MMU-5607764", "R-XTR-209560", "R-HSA-5689896", "R-HSA-9828211", "R-XTR-5607764", "R-BTA-202424", "R-HSA-75893", "R-HSA-936964", "R-SSC-6811558", "R-HSA-450321", "R-MMU-445989", "R-BTA-9758274", "R-SSC-937042", "R-BTA-937041", "R-RNO-202424", "R-RNO-205043", "R-MMU-975163", "R-DRE-9020702", "R-SSC-445989", "R-XTR-5689880", "R-MMU-75893", "R-HSA-166058", "R-BTA-937042", "R-HSA-209560", "R-MMU-209543", "R-HSA-975144", "R-SSC-9645460", "R-HSA-5675482", "R-RNO-209560", "R-SSC-166058", "R-HSA-5357786", "R-HSA-6811558", "R-DRE-209543", "R-BTA-193692", "R-XTR-975138", "R-MMU-2871837", "R-RNO-450302", "R-RNO-445989", "R-RNO-168638", "R-HSA-975110", "R-RNO-5689896", "R-HSA-1257604", "R-BTA-937039", "R-HSA-3371378", "R-HSA-193692", "R-XTR-975163", "R-HSA-445989", "R-DRE-937072", "R-SSC-1257604", "R-SSC-209560", "R-SSC-975871", "R-MMU-5676594", "R-HSA-975138", "R-HSA-5602571", "R-HSA-209543", "R-HSA-5676594", "R-HSA-936440", "R-DRE-450302", "R-BTA-937072", "R-HSA-2871837", "R-HSA-918233", "R-MMU-937039", "R-DRE-975163", "R-DRE-209560", "R-SSC-5689880", "R-SSC-937072", "R-DRE-5689896", "R-MMU-168638", "R-BTA-168638", "R-DRE-168638", "R-HSA-937072", "R-HSA-5607764", "R-XTR-9758274", "R-RNO-937039", "R-XTR-2871837", "R-DRE-5689880", "R-MMU-5357786", "R-BTA-5689896", "R-HSA-9013973", "R-MMU-166058", "R-RNO-166058", "R-HSA-9645460", "R-RNO-975871", "R-SSC-2871837", "R-HSA-975155", "R-HSA-5213460", "R-HSA-5668541", "R-RNO-5607764", "R-BTA-450302", "R-HSA-9692916", "R-BTA-9020702", "R-HSA-9014325", "R-BTA-5607764", "R-MMU-9758274", "R-BTA-975163", "R-HSA-202424", "R-XTR-5689896", "R-RNO-2871837", "PWY-7511", "R-HSA-9020702", "R-RNO-9758274", "R-HSA-5218900", "R-SSC-937039", "R-HSA-168638", "R-BTA-5689880", "R-MMU-6811558", "R-HSA-5689880", "R-SSC-209543", "R-SSC-193692", "R-MMU-9020702", "R-MMU-937072", "R-XTR-202424", "R-BTA-975144", "R-RNO-193692", "R-MMU-5689896", "R-XTR-209543", "R-MMU-937042", "R-DRE-445989", "R-BTA-450321", "R-MMU-5689880", "R-BTA-166058", "R-RNO-6811558", "R-HSA-168927", "R-BTA-6811558", "R-MMU-5668541"], "pathways": ["R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-XTR-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-3371378:r:Regulation by c-FLIP", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SSC-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DRE-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DRE-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-69416:r:Dimerization of procaspase-8", "R-MMU-69416:r:Dimerization of procaspase-8", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-MMU-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-RNO-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-XTR-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-DRE-937039:r:IRAK1 recruits IKK complex", "R-SSC-5689896:r:Ovarian tumor domain proteases", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-BTA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-SSC-9020702:r:Interleukin-1 signaling", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-SSC-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-BTA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-202424:r:Downstream TCR signaling", "R-XTR-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-XTR-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-XTR-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-202424:r:Downstream TCR signaling", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-DRE-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-XTR-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-975871:r:MyD88 cascade initiated on plasma membrane", "R-SSC-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-209560:r:NF-kB is activated and signals survival", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-XTR-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-75893:r:TNF signaling", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-SSC-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-202424:r:Downstream TCR signaling", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DRE-9020702:r:Interleukin-1 signaling", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-XTR-5689880:r:Ub-specific processing proteases", "R-MMU-75893:r:TNF signaling", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-BTA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-SSC-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-SSC-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DRE-209543:r:p75NTR recruits signalling complexes", "R-BTA-193692:r:Regulated proteolysis of p75NTR", "R-XTR-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-HSA-3371378:r:Regulation by c-FLIP", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-XTR-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-SSC-209560:r:NF-kB is activated and signals survival", "R-SSC-975871:r:MyD88 cascade initiated on plasma membrane", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DRE-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-DRE-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DRE-209560:r:NF-kB is activated and signals survival", "R-SSC-5689880:r:Ub-specific processing proteases", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-DRE-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-DRE-5689880:r:Ub-specific processing proteases", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-MMU-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-975871:r:MyD88 cascade initiated on plasma membrane", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-BTA-9020702:r:Interleukin-1 signaling", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-202424:r:Downstream TCR signaling", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "PWY-7511:t:protein ubiquitination", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-SSC-937039:r:IRAK1 recruits IKK complex", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-SSC-209543:r:p75NTR recruits signalling complexes", "R-SSC-193692:r:Regulated proteolysis of p75NTR", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-XTR-202424:r:Downstream TCR signaling", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-XTR-209543:r:p75NTR recruits signalling complexes", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DRE-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-168927:r:TICAM1, RIP1-mediated IKK complex recruitment", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway"], "type": "Domain"}, "IPR049343": {"description": "Transposase protein", "go_ids": [], "go_terms": [], "name": "Transposase_29", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049344": {"description": "Potential transfer protein TraK-like", "go_ids": [], "go_terms": [], "name": "TraK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049345": {"description": "Immune protein Tsi1", "go_ids": [], "go_terms": [], "name": "Tsi1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049346": {"description": "Immune protein Tsi1-like superfamily", "go_ids": [], "go_terms": [], "name": "Tsi1-like_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR049347": {"description": "Antitoxin TsiV3", "go_ids": [], "go_terms": [], "name": "TsiV3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049348": {"description": "Antitoxin TsiV3 superfamily", "go_ids": [], "go_terms": [], "name": "TsiV3_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR049349": {"description": "DUF2264, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF2264_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049350": {"description": "Tailspike protein-like, Ig-like domain", "go_ids": [], "go_terms": [], "name": "TSP_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049351": {"description": "Immunoglobulin delta heavy chain-like, delta linker region", "go_ids": [], "go_terms": [], "name": "IgD_del_linker", "pathway_ids": ["R-HSA-983695", "R-HSA-5690714", "R-HSA-9679191"], "pathways": ["R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-HSA-9679191:r:Potential therapeutics for SARS"], "type": "Domain"}, "IPR049352": {"description": "Rolling stone", "go_ids": [], "go_terms": [], "name": "Rost", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049353": {"description": "DNA gyrase subunit B, hook", "go_ids": [], "go_terms": [], "name": "GyrB_hook", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638771"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638771:r:Action of antimicrobials"], "type": "Domain"}, "IPR049354": {"description": "Baseplate hub protein gp44-like, N-terminal", "go_ids": [], "go_terms": [], "name": "GpP-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049355": {"description": "Methionyl-tRNA formyltransferase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Formyl_trans-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049356": {"description": "Small heat shock protein p36, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Tsp36_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049357": {"description": "Small heat shock protein p36, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Tsp36_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR049358": {"description": "Type VI secretion system TssR-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "T6SS_TssR-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049359": {"description": "Type VI secretion system TssR-like, second domain", "go_ids": [], "go_terms": [], "name": "T6SS_TssR-like_dom_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049360": {"description": "Type VI secretion system TssR-like, VWA domain", "go_ids": [], "go_terms": [], "name": "T6SS_TssR-like_VWA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049361": {"description": "Zinc finger protein ZFPM1/2, PR domain", "go_ids": [], "go_terms": [], "name": "ZFPM1/2_PR", "pathway_ids": ["R-HSA-983231", "R-MMU-8936459", "R-MMU-983231", "R-HSA-9690406", "R-HSA-8936459"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "type": "Domain"}, "IPR049362": {"description": "TELO2-interacting protein 1, middle region repeats", "go_ids": [], "go_terms": [], "name": "TTI1_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR049363": {"description": "RMI1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RMI1_N", "pathway_ids": ["R-DRE-5693607", "R-BTA-69473", "R-BTA-5685938", "R-HSA-5685942", "R-HSA-5693616", "R-HSA-9704646", "R-MMU-6804756", "R-MMU-5693616", "R-MMU-5685938", "R-MMU-69473", "R-DRE-5693568", "R-HSA-9709570", "R-HSA-5693607", "R-BTA-6804756", "R-BTA-5693616", "R-BTA-5693579", "R-BTA-5693607", "R-MMU-5693568", "R-MMU-5693579", "R-HSA-5693568", "R-HSA-5685938", "R-MMU-5693607", "R-DRE-5693579", "R-HSA-9701192", "R-DRE-6804756", "R-BTA-5693568", "R-HSA-69473", "R-MMU-5685942", "R-DRE-5685942", "R-HSA-9709603", "R-HSA-6804756", "R-DRE-69473", "R-HSA-9704331", "R-BTA-5685942", "R-DRE-5693616", "R-HSA-5693554", "R-HSA-5693579", "R-DRE-5685938"], "pathways": ["R-DRE-5693607:r:Processing of DNA double-strand break ends", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-BTA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-DRE-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DRE-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-DRE-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-DRE-5685938:r:HDR through Single Strand Annealing (SSA)"], "type": "Domain"}, "IPR049364": {"description": "Tubulin-like protein TubZ, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TubZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049365": {"description": "Flagellin, barrel domain", "go_ids": [], "go_terms": [], "name": "FLIC_barrel", "pathway_ids": ["R-GGA-433822", "R-HSA-975871", "R-GGA-977240", "R-GGA-451534", "R-HSA-168176", "R-HSA-5602680", "R-HSA-5603037", "R-HSA-844623"], "pathways": ["R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-GGA-977240:r:MyD88 cascade initiated on plasma membrane", "R-GGA-451534:r:TLR5 cascade", "R-HSA-168176:r:Toll Like Receptor 5 (TLR5) Cascade", "R-HSA-5602680:r:MyD88 deficiency (TLR5)", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR049366": {"description": "Rhamnogalacturonan lyase family 11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RGL11_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049367": {"description": "Testis-expressed protein 13C/D, MVPLGDSxSHS repeat", "go_ids": [], "go_terms": [], "name": "TX13C/D_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR049368": {"description": "Chorismatase FkbO/Hyg5-like, N-terminal", "go_ids": [], "go_terms": [], "name": "FkbO_Hyg5-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049369": {"description": "BF1531-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BF1531-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049370": {"description": "Fimbrium tip subunit Fim1C-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Fim1C-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049371": {"description": "GspD-like, N0 domain", "go_ids": [], "go_terms": [], "name": "GspD-like_N0", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR049372": {"description": "Protein phosphatase 1 regulatory subunit 21, C-terminal", "go_ids": [], "go_terms": [], "name": "PPP1R21_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049373": {"description": "L-tyrosine decarboxylase, C-terminal", "go_ids": [], "go_terms": [], "name": "TyrDC_C", "pathway_ids": ["PWY-5870", "PWY-6309", "PWY-5871", "PWY-7007", "PWY-6322", "PWY-6055", "PWY-8037", "PWY-7769", "PWY-7557", "PWY-7826", "PWY-6262", "PWY-6133", "PWY-6627", "PWY-8376", "PWY-5163", "PWY-3581", "PWY-6340", "PWY-5956", "PWY-5873", "PWY-7154", "PWY-5254", "PWY-7620", "PWY-3542", "PWY-6633", "PWY-7230", "PWY-6959", "PWY-7931", "PWY-7352", "PWY-5474", "PWY-5113", "PWY-7372", "PWY-5872", "PWY-7782", "PWY-7690", "PWY-8158", "PWY-5826", "PWY-7419", "PWY-6935", "PWY-7297", "PWY-8166", "PWY-6802", "PWY-7742", "PWY-3385", "PWY-7480", "PWY-7741", "PWY-8387", "PWY-8085", "PWY-5706", "PWY-8358"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6055:t:dimethylsulfoniopropanoate biosynthesis II (Spartina)", "PWY-8037:t:saliniketal A biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-6133:t:(S)-reticuline biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8376:t:benzene degradation III (anaerobic)", "PWY-5163:t:p-cumate degradation to 2-hydroxypentadienoate", "PWY-3581:t:(S)-reticuline biosynthesis I", "PWY-6340:t:5,5'-dehydrodivanillate degradation", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-7154:t:ergosterol biosynthesis II", "PWY-5254:t:methanofuran biosynthesis", "PWY-7620:t:naphthalene degradation (anaerobic)", "PWY-3542:t:choline biosynthesis II", "PWY-6633:t:caffeine degradation V (bacteria, via trimethylurate)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-6959:t:L-ascorbate degradation V", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-5474:t:hydroxycinnamic acid tyramine amides biosynthesis", "PWY-5113:t:UDP-D-apiose biosynthesis (from UDP-D-glucuronate)", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7690:t:holomycin biosynthesis", "PWY-8158:t:ibotenate and muscimol biosynthesis", "PWY-5826:t:hypoglycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6935:t:seleno-amino acid detoxification and volatilization II", "PWY-7297:t:octopamine biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-3385:t:choline biosynthesis I", "PWY-7480:t:2,3-dihydroxybenzoate degradation", "PWY-7741:t:phthiocerol biosynthesis", "PWY-8387:t:microcin C biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-5706:t:alliin metabolism", "PWY-8358:t:curacin A biosynthesis"], "type": "Domain"}, "IPR049374": {"description": "Adenovirus fiber, head domain", "go_ids": [], "go_terms": [], "name": "Fiber_head_adenovirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049375": {"description": "Fibroin heavy chain, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Fib-H_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049376": {"description": "Fibroin heavy chain, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "Fib-H_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR049377": {"description": "Factor H binding protein, N-terminal", "go_ids": [], "go_terms": [], "name": "FHBP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049378": {"description": "Factor H binding protein", "go_ids": [], "go_terms": [], "name": "FHBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049379": {"description": "Factor H binding protein B domain", "go_ids": [], "go_terms": [], "name": "FhbB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049380": {"description": "Factor H binding protein B domain superfamily", "go_ids": [], "go_terms": [], "name": "FhbB_dom_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR049381": {"description": "3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "UbiD-like_C", "pathway_ids": ["PWY-6978", "PWY-5856", "PWY-6708", "PWY-5857", "PWY-5855"], "pathways": ["PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)"], "type": "Domain"}, "IPR049382": {"description": "Carbohydrate kinase FGGY, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FGGY_C_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049383": {"description": "3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "UbiD-like_N", "pathway_ids": ["PWY-6978", "PWY-5856", "PWY-6708", "PWY-5857", "PWY-5855"], "pathways": ["PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)"], "type": "Domain"}, "IPR049384": {"description": "P56", "go_ids": [], "go_terms": [], "name": "P56", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049385": {"description": "FAK1-like, FERM domain C-lobe", "go_ids": [], "go_terms": [], "name": "FAK1-like_FERM_C", "pathway_ids": ["R-HSA-5663213", "R-HSA-6798695", "R-CEL-375165", "R-HSA-8874081", "R-RNO-372708", "R-RNO-9020558", "R-CEL-354194", "R-RNO-9009391", "R-MMU-9009391", "R-MMU-4420097", "R-HSA-418885", "R-RNO-354194", "R-HSA-375165", "R-CEL-5673001", "R-HSA-3928662", "R-RNO-2029482", "R-RNO-9860927", "R-RNO-111465", "R-RNO-8874081", "R-HSA-4420097", "R-RNO-5663213", "R-MMU-372708", "R-MMU-5663213", "R-MMU-8874081", "R-CEL-418885", "R-MMU-9013420", "R-RNO-354192", "R-CEL-354192", "R-RNO-3928662", "R-MMU-9020558", "R-RNO-375165", "R-MMU-375165", "R-CEL-3928662", "R-RNO-5673001", "R-MMU-111465", "R-MMU-5673001", "R-HSA-9020558", "R-HSA-354192", "R-HSA-9664422", "R-HSA-9013420", "R-CEL-9860927", "R-MMU-391160", "R-HSA-354194", "R-RNO-391160", "R-MMU-354194", "R-HSA-2029482", "R-CEL-5663213", "R-HSA-9634638", "R-MMU-2029482", "R-RNO-418885", "R-HSA-5673001", "R-CEL-2029482", "R-MMU-9860927", "R-HSA-9009391", "R-CEL-4420097", "R-MMU-3928662", "R-HSA-111465", "R-CEL-9013420", "R-CEL-9009391", "R-HSA-9860927", "R-HSA-372708", "R-CEL-8874081", "R-RNO-9013420", "R-MMU-354192", "R-RNO-4420097", "R-HSA-391160", "R-MMU-418885"], "pathways": ["R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-9020558:r:Interleukin-2 signaling", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-418885:r:DCC mediated attractive signaling", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-CEL-418885:r:DCC mediated attractive signaling", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9020558:r:Interleukin-2 signaling", "R-HSA-354192:r:Integrin signaling", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-354192:r:Integrin signaling", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR049386": {"description": "Sulfide dehydrogenase [flavocytochrome c] flavoprotein chain, central", "go_ids": [], "go_terms": [], "name": "FCSD_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049387": {"description": "UFSP2, second domain", "go_ids": [], "go_terms": [], "name": "UFSP2-like_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049388": {"description": "Fibrillin, first EGF domain", "go_ids": [], "go_terms": [], "name": "FBN_EGF_N", "pathway_ids": ["R-HSA-1474228", "R-HSA-2129379", "R-BTA-1566948", "R-HSA-216083", "R-MMU-2173789", "R-BTA-1474228", "R-HSA-1566948", "R-BTA-2173789", "R-MMU-8957275", "R-BTA-8957275", "R-MMU-381426", "R-BTA-381426", "R-MMU-216083", "R-HSA-8957275", "R-MMU-1566948", "R-BTA-216083", "R-BTA-2129379", "R-HSA-381426", "R-HSA-2173789", "R-MMU-2129379", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-BTA-1566948:r:Elastic fibre formation", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-1566948:r:Elastic fibre formation", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1566948:r:Elastic fibre formation", "R-BTA-216083:r:Integrin cell surface interactions", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR049389": {"description": "UPF0150", "go_ids": [], "go_terms": [], "name": "UPF0150", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049390": {"description": "Fas-binding factor 1, C-terminal", "go_ids": [], "go_terms": [], "name": "FBF1_C", "pathway_ids": ["R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR049391": {"description": "Fatty acid synthase, pseudo-KR domain", "go_ids": [], "go_terms": [], "name": "FAS_pseudo-KR", "pathway_ids": ["PWY-8174", "PWY-5147", "PWY-5142", "PWY-8427", "PWY-6799", "PWY-8280", "PWY-6519", "PWY-8203", "PWY-7663", "PWY-5367", "PWY-7746", "PWY-8438", "PWY-5989", "PWY-4381", "PWY-5966", "PWY-7723", "PWY-8012", "PWY-5971", "PWY-8173", "PWY-5366", "PWY-7664", "PWY-7858", "PWY-8175", "PWY-8049", "PWYG-321", "PWY-7388", "PWY-5994", "PWY-5973", "PWY-8279", "PWY-8047", "PWY-6282", "R-HSA-163765", "R-HSA-9029558", "R-HSA-75105", "R-HSA-9918487", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-5147:t:oleate biosynthesis I (plants)", "PWY-5142:t:acyl-[acyl-carrier protein] thioesterase pathway", "PWY-8427:t:2-allylmalonyl-CoA biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-8280:t:stearate biosynthesis IV", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWY-5367:t:petroselinate biosynthesis", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "PWY-5966:t:fatty acid biosynthesis initiation (type I)", "PWY-7723:t:bacterial bioluminescence", "PWY-8012:t:mupirocin biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis", "PWY-5366:t:palmitoleate biosynthesis II (plants and bacteria)", "PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-7388:t:octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-8279:t:palmitate biosynthesis III", "PWY-8047:t:bryostatin biosynthesis", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR049392": {"description": "Formamidopyrimidine-DNA glycosylase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FPG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049393": {"description": "Selenocysteine-specific elongation factor, 3rd domain", "go_ids": [], "go_terms": [], "name": "eEFSec_III", "pathway_ids": ["R-HSA-2408557"], "pathways": ["R-HSA-2408557:r:Selenocysteine synthesis"], "type": "Domain"}, "IPR049394": {"description": "Selenocysteine-specific elongation factor, C-terminal RIFT domain", "go_ids": [], "go_terms": [], "name": "eEFSec_C", "pathway_ids": ["R-HSA-2408557"], "pathways": ["R-HSA-2408557:r:Selenocysteine synthesis"], "type": "Domain"}, "IPR049395": {"description": "ECT2, PH domain", "go_ids": [], "go_terms": [], "name": "ECT2_PH", "pathway_ids": ["R-HSA-193648", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013026", "R-MMU-416482", "R-MMU-8980692", "R-MMU-193648", "R-HSA-9013148", "R-HSA-9013026", "R-HSA-416482", "R-MMU-9013148", "R-MMU-9013149"], "pathways": ["R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR049396": {"description": "ECT2, BRCT0 domain", "go_ids": [], "go_terms": [], "name": "ECT2_BRCT0", "pathway_ids": ["R-HSA-193648", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013026", "R-MMU-416482", "R-MMU-8980692", "R-MMU-193648", "R-HSA-9013148", "R-HSA-9013026", "R-HSA-416482", "R-MMU-9013148", "R-MMU-9013149"], "pathways": ["R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR049397": {"description": "HTH-type transcriptional regulator EthR, C-terminal domain", "go_ids": [], "go_terms": [], "name": "EthR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049398": {"description": "ETF-QO/FixC, ubiquinone-binding", "go_ids": [], "go_terms": [], "name": "ETF-QO/FixC_UQ-bd", "pathway_ids": ["R-SSC-611105", "R-RNO-611105", "R-HSA-611105", "R-DDI-611105", "R-CEL-611105", "R-MMU-611105", "R-SPO-611105", "R-SCE-611105", "R-DME-611105"], "pathways": ["R-SSC-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-DDI-611105:r:Respiratory electron transport", "R-CEL-611105:r:Respiratory electron transport", "R-MMU-611105:r:Respiratory electron transport", "R-SPO-611105:r:Respiratory electron transport", "R-SCE-611105:r:Respiratory electron transport", "R-DME-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR049399": {"description": "BDLP-like, helical domain", "go_ids": [], "go_terms": [], "name": "BDLP-like_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049400": {"description": "Cytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domain", "go_ids": [], "go_terms": [], "name": "DYNC2H1_AAA_dom", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-RNO-5610787", "R-RNO-5620924", "R-CEL-5620924", "R-HSA-5610787", "R-MMU-5610787"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR049401": {"description": "DZF domain, N-terminal", "go_ids": [], "go_terms": [], "name": "DZF_dom_N", "pathway_ids": ["R-DME-9833482", "R-HSA-6798695", "R-MMU-9833482", "R-XTR-9833482", "R-DRE-9762293", "R-XTR-9762293", "R-MMU-9762293", "R-DRE-6798695", "R-HSA-9833482", "R-DME-6798695", "R-MMU-6798695", "R-XTR-6798695", "R-RNO-9833482", "R-DRE-9833482", "R-RNO-6798695", "R-HSA-9762293"], "pathways": ["R-DME-9833482:r:PKR-mediated signaling", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9833482:r:PKR-mediated signaling", "R-XTR-9833482:r:PKR-mediated signaling", "R-DRE-9762293:r:Regulation of CDH11 gene transcription", "R-XTR-9762293:r:Regulation of CDH11 gene transcription", "R-MMU-9762293:r:Regulation of CDH11 gene transcription", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9833482:r:PKR-mediated signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-9833482:r:PKR-mediated signaling", "R-DRE-9833482:r:PKR-mediated signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9762293:r:Regulation of CDH11 gene transcription"], "type": "Domain"}, "IPR049402": {"description": "DZF domain, C-terminal", "go_ids": [], "go_terms": [], "name": "DZF_dom_C", "pathway_ids": ["R-DME-9833482", "R-HSA-6798695", "R-MMU-9833482", "R-XTR-9833482", "R-DRE-9762293", "R-XTR-9762293", "R-MMU-9762293", "R-DRE-6798695", "R-HSA-9833482", "R-DME-6798695", "R-MMU-6798695", "R-XTR-6798695", "R-RNO-9833482", "R-DRE-9833482", "R-RNO-6798695", "R-HSA-9762293"], "pathways": ["R-DME-9833482:r:PKR-mediated signaling", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9833482:r:PKR-mediated signaling", "R-XTR-9833482:r:PKR-mediated signaling", "R-DRE-9762293:r:Regulation of CDH11 gene transcription", "R-XTR-9762293:r:Regulation of CDH11 gene transcription", "R-MMU-9762293:r:Regulation of CDH11 gene transcription", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9833482:r:PKR-mediated signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-9833482:r:PKR-mediated signaling", "R-DRE-9833482:r:PKR-mediated signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9762293:r:Regulation of CDH11 gene transcription"], "type": "Domain"}, "IPR049403": {"description": "Ell binding protein Ebp1, C-terminal", "go_ids": [], "go_terms": [], "name": "Ebp1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049404": {"description": "Enhancer of mRNA-decapping protein 4, C-terminal", "go_ids": [], "go_terms": [], "name": "EDC4_C", "pathway_ids": ["R-RNO-430039", "R-MMU-430039", "R-DME-430039", "R-DRE-430039", "R-HSA-430039"], "pathways": ["R-RNO-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-MMU-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DME-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-DRE-430039:r:mRNA decay by 5' to 3' exoribonuclease", "R-HSA-430039:r:mRNA decay by 5' to 3' exoribonuclease"], "type": "Domain"}, "IPR049405": {"description": "Edema factor, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "EF_HD", "pathway_ids": ["R-HSA-5210891"], "pathways": ["R-HSA-5210891:r:Uptake and function of anthrax toxins"], "type": "Domain"}, "IPR049406": {"description": "Zinc transporter ZIP4/12, EF-hand", "go_ids": [], "go_terms": [], "name": "ZIP4_12_EF-hand", "pathway_ids": ["R-HSA-5619088", "R-MMU-442380", "R-HSA-442380", "R-BTA-442380", "R-RNO-442380"], "pathways": ["R-HSA-5619088:r:Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)", "R-MMU-442380:r:Zinc influx into cells by the SLC39 gene family", "R-HSA-442380:r:Zinc influx into cells by the SLC39 gene family", "R-BTA-442380:r:Zinc influx into cells by the SLC39 gene family", "R-RNO-442380:r:Zinc influx into cells by the SLC39 gene family"], "type": "Domain"}, "IPR049407": {"description": "Ubiquitin carboxyl-terminal hydrolase 38-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Usp38-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049408": {"description": "UV-stimulated scaffold protein A, N-terminal alpha-solenoid repeats", "go_ids": [], "go_terms": [], "name": "UVSSA_N_a-solenoid_rpt", "pathway_ids": ["R-RNO-6781823", "R-DRE-6782210", "R-HSA-6781827", "R-MMU-6782135", "R-RNO-6782135", "R-HSA-6782135", "R-CEL-6782210", "R-HSA-6781823", "R-CEL-6781823", "R-MMU-6781823", "R-DRE-6782135", "R-XTR-6782210", "R-CEL-6782135", "R-XTR-6782135", "R-HSA-6782210", "R-MMU-6782210", "R-XTR-6781823", "R-DRE-6781823", "R-RNO-6782210"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6782135:r:Dual incision in TC-NER", "R-XTR-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-XTR-6782135:r:Dual incision in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER"], "type": "Repeat"}, "IPR049409": {"description": "ATP-dependent DNA helicase uvsW, N-terminal", "go_ids": [], "go_terms": [], "name": "UvsW_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049410": {"description": "Endo-beta-N-acetylglucosaminidase EndoS-like, Ig-like domain", "go_ids": [], "go_terms": [], "name": "EndoS-like_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049411": {"description": "V-cyclin, C-terminal domain", "go_ids": [], "go_terms": [], "name": "V-cyclin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049412": {"description": "Minor capsid protein V18-like, jelly roll domain", "go_ids": [], "go_terms": [], "name": "V18-like_jelly_roll", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049413": {"description": "Minor capsid protein V18/19-like, jelly roll domain superfamily", "go_ids": [], "go_terms": [], "name": "V18/19-like_jelly_roll_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR049414": {"description": "VopL, C-terminal dimerization domain", "go_ids": [], "go_terms": [], "name": "VopL_VCD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049415": {"description": "VopL, C-terminal dimerization domain superfamily", "go_ids": [], "go_terms": [], "name": "VopL_VCD_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR049416": {"description": "Malonyl-CoA-[acyl-carrier-protein] transacylase, small domain", "go_ids": [], "go_terms": [], "name": "VinK-like_small", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049417": {"description": "VipE-like, N-terminal", "go_ids": [], "go_terms": [], "name": "VipE-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049418": {"description": "VopS, N-terminal domain", "go_ids": [], "go_terms": [], "name": "VopS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049419": {"description": "Reelin, subrepeat B", "go_ids": [], "go_terms": [], "name": "Reelin_subrepeat-B", "pathway_ids": ["PWY-7884", "R-MMU-8866376", "R-HSA-8866376", "R-RNO-8866376"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-MMU-8866376:r:Reelin signalling pathway", "R-HSA-8866376:r:Reelin signalling pathway", "R-RNO-8866376:r:Reelin signalling pathway"], "type": "Repeat"}, "IPR049420": {"description": "EPCAM/Trop-2, C-terminal", "go_ids": [], "go_terms": [], "name": "EPCAM-Trop-2_C", "pathway_ids": ["R-HSA-9638630", "R-RNO-202733", "R-MMU-202733", "R-HSA-9927432", "R-HSA-9938206", "R-GGA-202733", "R-SSC-202733", "R-HSA-9927418", "R-HSA-202733", "R-HSA-9927426"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Domain"}, "IPR049421": {"description": "Inner capsid protein VP1, small protrusion domain", "go_ids": [], "go_terms": [], "name": "VP1_protrusion", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049422": {"description": "Capsid protein VP1/VP3, C-terminal", "go_ids": [], "go_terms": [], "name": "VP1/VP3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049423": {"description": "Viral structural protein 5", "go_ids": [], "go_terms": [], "name": "VP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049425": {"description": "Vacuolar protein sorting-associated protein 27, GAT-like domain", "go_ids": [], "go_terms": [], "name": "Vps27_GAT-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049426": {"description": "Acyl-CoA dehydrogenase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Acyl-CoA-dh-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049427": {"description": "Acyl-ACP thioesterase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Acyl-ACP_TE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049428": {"description": "RecA-like, N-terminal", "go_ids": [], "go_terms": [], "name": "RecA-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049430": {"description": "ATP-dependent DNA helicase uvsW, N-terminal domain superfamily", "go_ids": [], "go_terms": [], "name": "UvsW_N_sf", "pathway_ids": [], "pathways": [], "type": "Homologous_superfamily"}, "IPR049431": {"description": "UV-stimulated scaffold protein A, C-terminal domain", "go_ids": [], "go_terms": [], "name": "UVSSA_C", "pathway_ids": ["R-RNO-6781823", "R-DRE-6782210", "R-HSA-6781827", "R-MMU-6782135", "R-RNO-6782135", "R-HSA-6782135", "R-CEL-6782210", "R-HSA-6781823", "R-CEL-6781823", "R-MMU-6781823", "R-DRE-6782135", "R-XTR-6782210", "R-CEL-6782135", "R-XTR-6782135", "R-HSA-6782210", "R-MMU-6782210", "R-XTR-6781823", "R-DRE-6781823", "R-RNO-6782210"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6782135:r:Dual incision in TC-NER", "R-XTR-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-XTR-6782135:r:Dual incision in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER"], "type": "Domain"}, "IPR049432": {"description": "Virion DNA-directed RNA polymerase domain", "go_ids": [], "go_terms": [], "name": "vRNAP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049433": {"description": "Virion DNA-directed RNA polymerase, plug insertion domain", "go_ids": [], "go_terms": [], "name": "vRNAP_plug", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049434": {"description": "VPg", "go_ids": [], "go_terms": [], "name": "VPg", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP"], "type": "Family"}, "IPR049435": {"description": "CRISPR associated protein Cas6, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cas_Cas6_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049437": {"description": "tRNA synthetases class I (E and Q), anti-codon binding domain", "go_ids": [], "go_terms": [], "name": "tRNA-synt_1c_C2", "pathway_ids": ["R-MMU-9856649", "R-HSA-379726", "R-DDI-9856649", "R-BTA-9856649", "R-HSA-2408522", "R-HSA-6782315", "R-RNO-9856649", "R-DME-9856649", "R-HSA-9856649", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR049438": {"description": "Trehalose synthase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TreT_GT1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049439": {"description": "TRAFD1/XAF1, zinc finger", "go_ids": [], "go_terms": [], "name": "TRAFD1-XIAF1_Znf", "pathway_ids": ["R-HSA-909733"], "pathways": ["R-HSA-909733:r:Interferon alpha/beta signaling"], "type": "Domain"}, "IPR049440": {"description": "TNF receptor-associated factor 3/5, RING domain", "go_ids": [], "go_terms": [], "name": "TRAF3/5_RING", "pathway_ids": ["R-HSA-918233", "R-HSA-5668541", "R-MMU-5676594", "R-HSA-9705671", "R-HSA-5602571", "R-HSA-9013973", "R-HSA-5689896", "R-HSA-9828211", "R-HSA-9692916", "R-HSA-5676594", "R-MMU-5668541", "R-HSA-9824878", "R-HSA-936440", "R-MMU-5689896", "R-HSA-936964", "R-MMU-9824878", "R-MMU-936964"], "pathways": ["R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-5602571:r:TRAF3 deficiency - HSE", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "type": "Domain"}, "IPR049441": {"description": "TRAF2, second zinc finger", "go_ids": [], "go_terms": [], "name": "TRAF2_Znf", "pathway_ids": ["R-MMU-5357786", "R-MMU-5676594", "R-HSA-5218900", "R-HSA-5689880", "R-HSA-933542", "R-HSA-5675482", "R-MMU-5675482", "R-HSA-5676594", "R-HSA-9758274", "R-HSA-75893", "R-MMU-5357956", "R-HSA-5357786", "R-HSA-69416", "R-HSA-5213460", "R-MMU-5689880", "R-HSA-5668541", "R-MMU-69416", "R-HSA-933541", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5668541", "R-MMU-5357905", "R-HSA-9693928", "R-MMU-5218900", "R-MMU-3371378", "R-HSA-140534", "R-MMU-9758274", "R-HSA-3371378", "R-MMU-75893"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-75893:r:TNF signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-69416:r:Dimerization of procaspase-8", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-69416:r:Dimerization of procaspase-8", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-MMU-3371378:r:Regulation by c-FLIP", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-3371378:r:Regulation by c-FLIP", "R-MMU-75893:r:TNF signaling"], "type": "Domain"}, "IPR049442": {"description": "Thiamin pyrophosphokinase-like, substrate-binding domain", "go_ids": [], "go_terms": [], "name": "Thi_PPkinase-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049443": {"description": "Tetracyclin repressor YgfC-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_YgfC-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049444": {"description": "TetR/AcrR transcriptional repressor, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_C_44", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049445": {"description": "Transcriptional regulator SbtR-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_SbtR-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049446": {"description": "Tetracyclin repressor AcrR1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_AcrR1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049447": {"description": "A9CJY8-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "A9CJY8-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049448": {"description": "ACAD9/ACADV-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ACAD9/ACADV-like_C", "pathway_ids": ["PWY-7654", "PWY-8181", "R-HSA-381038", "R-HSA-77305", "R-MMU-77305", "R-MMU-6799198", "R-RNO-77305", "R-HSA-6799198", "R-BTA-77305", "R-RNO-6799198"], "pathways": ["PWY-7654:t:(8E,10E)-dodeca-8,10-dienol biosynthesis", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-MMU-6799198:r:Complex I biogenesis", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-6799198:r:Complex I biogenesis", "R-BTA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-RNO-6799198:r:Complex I biogenesis"], "type": "Domain"}, "IPR049449": {"description": "Acyl-CoA thioesterase-like, N-terminal HotDog domain", "go_ids": [], "go_terms": [], "name": "TesB_ACOT8-like_N", "pathway_ids": ["R-MMU-2046106", "R-MMU-193368", "R-SCE-2046106", "R-RNO-2046106", "R-SCE-390247", "R-HSA-389887", "R-HSA-193368", "R-MMU-9033241", "R-RNO-9033241", "R-MMU-389887", "R-SCE-389887", "R-RNO-389887", "R-HSA-390247", "R-MMU-390247", "R-SCE-9033241", "R-RNO-193368", "R-SCE-193368", "R-HSA-2046106", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SCE-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-SCE-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-SCE-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-SCE-9033241:r:Peroxisomal protein import", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-SCE-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR049450": {"description": "Acyl-CoA thioesterase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ACOT8-like_C", "pathway_ids": ["R-RNO-9033241", "R-MMU-389887", "R-MMU-2046106", "R-MMU-193368", "R-RNO-389887", "R-HSA-390247", "R-MMU-390247", "R-RNO-193368", "R-RNO-2046106", "R-HSA-389887", "R-HSA-193368", "R-MMU-9033241", "R-HSA-2046106", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR049451": {"description": "Adhesin AWP2-like, C-terminal YTTT repeat", "go_ids": [], "go_terms": [], "name": "AWP2-like_YTTT_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR049452": {"description": "Anoctamin, transmembrane domain", "go_ids": [], "go_terms": [], "name": "Anoctamin_TM", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-HSA-9733458", "R-SCE-6798695", "R-HSA-2672351", "R-HSA-381753", "R-MMU-8957275", "R-SCE-2672351", "R-BTA-2672351", "R-RNO-2672351", "R-MMU-2672351", "R-MMU-381426", "R-DRE-2672351", "R-SPO-2672351", "R-MMU-6798695", "R-HSA-8957275", "R-HSA-381426"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9733458:r:Induction of Cell-Cell Fusion", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-SCE-2672351:r:Stimuli-sensing channels", "R-BTA-2672351:r:Stimuli-sensing channels", "R-RNO-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-2672351:r:Stimuli-sensing channels", "R-SPO-2672351:r:Stimuli-sensing channels", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR049453": {"description": "Integral membrane bound transporter domain", "go_ids": [], "go_terms": [], "name": "Memb_transporter_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049454": {"description": "Protelomerase TelK-like, stirrup domain", "go_ids": [], "go_terms": [], "name": "TelK_stirrup", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049455": {"description": "Set1/Ash2 histone methyltransferase complex subunit ASH2-like, PHD zinc finger", "go_ids": [], "go_terms": [], "name": "ASH2-like_PHD", "pathway_ids": ["R-MMU-8936459", "R-HSA-5617472", "R-MMU-3214841", "R-DME-9772755", "R-HSA-3769402", "R-HSA-9772755", "R-CEL-8936459", "R-MMU-9818564", "R-HSA-8936459", "R-HSA-9944997", "R-MMU-201722", "R-CEL-3214841", "R-DME-201722", "R-HSA-9841922", "R-HSA-201722", "R-HSA-9909649", "R-SPO-9772755", "R-DME-8936459", "R-HSA-3214841", "R-HSA-9818564", "R-CEL-9772755", "R-MMU-9772755", "R-DME-9909649"], "pathways": ["R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription"], "type": "Domain"}, "IPR049456": {"description": "Anoctamin, alpha-beta plait domain, fungal-type", "go_ids": [], "go_terms": [], "name": "Anoctamin_N_fung", "pathway_ids": ["R-SPO-2672351", "R-SPO-6798695"], "pathways": ["R-SPO-2672351:r:Stimuli-sensing channels", "R-SPO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR049457": {"description": "Emfourin", "go_ids": [], "go_terms": [], "name": "Emfourin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049458": {"description": "Transmembrane protein EpsG-like", "go_ids": [], "go_terms": [], "name": "EpsG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049459": {"description": "Bleomycin resistance protein domain", "go_ids": [], "go_terms": [], "name": "Bleomycin_resist_prot_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049460": {"description": "Protelomerase TelK-like, muzzle domain", "go_ids": [], "go_terms": [], "name": "TelK_muzzle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049461": {"description": "AAA+ ATPase, lid domain", "go_ids": [], "go_terms": [], "name": "AAA_lid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049462": {"description": "Haptoglobin-hemoglobin receptor", "go_ids": [], "go_terms": [], "name": "HpHbR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049463": {"description": "Putative poly(A) polymerase, catalytic subunit, C-terminal, mimivirus", "go_ids": [], "go_terms": [], "name": "APMV_polyA_pol_cat_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049464": {"description": "Conjugal transfer protein-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TcpM-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049465": {"description": "CRISPR-associated endonuclease Cas9, alpha-helical lobe", "go_ids": [], "go_terms": [], "name": "Cas9_lobe", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049466": {"description": "Complement component 3, CUB domain, first segment", "go_ids": [], "go_terms": [], "name": "C3_CUB1", "pathway_ids": ["R-HSA-6798695", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-375276", "R-BTA-173736", "R-HSA-9660826", "R-BTA-6798695", "R-MMU-375276", "R-MMU-8957275", "R-MMU-418594", "R-BTA-174577", "R-RNO-418594", "R-RNO-977606", "R-MMU-173736", "R-RNO-174577", "R-RNO-381426", "R-BTA-8957275", "R-HSA-418594", "R-MMU-198933", "R-BTA-418594", "R-HSA-977606", "R-RNO-8957275", "R-RNO-375276", "R-MMU-381426", "R-MMU-174577", "R-HSA-173736", "R-RNO-173736", "R-HSA-174577", "R-BTA-381426", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-HSA-381426", "R-RNO-6798695", "R-BTA-375276", "R-BTA-977606"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-173736:r:Alternative complement activation", "R-RNO-174577:r:Activation of C3 and C5", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-BTA-977606:r:Regulation of Complement cascade"], "type": "Domain"}, "IPR049467": {"description": "Ubiquitin-associated protein 1-like, UBA2 domain", "go_ids": [], "go_terms": [], "name": "UBAP-1-like_UBA2", "pathway_ids": ["R-RNO-917729", "R-HSA-9610379", "R-HSA-917729", "R-DRE-917729", "R-MMU-917729", "R-HSA-174490", "R-HSA-9615710", "R-HSA-162588"], "pathways": ["R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-9610379:r:HCMV Late Events", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DRE-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-162588:r:Budding and maturation of HIV virion"], "type": "Domain"}, "IPR049468": {"description": "Restriction endonuclease type II-like domain", "go_ids": [], "go_terms": [], "name": "Restrct_endonuc-II-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049470": {"description": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, C-terminal", "go_ids": [], "go_terms": [], "name": "TRM61_C", "pathway_ids": ["PWY-6829", "R-HSA-6782315", "R-HSA-9937008", "R-HSA-6787450"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR049471": {"description": "SPP1 phage GP23.1-like", "go_ids": [], "go_terms": [], "name": "SPP1_GP23.1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049472": {"description": "MRN complex-interacting protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MRNIP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049473": {"description": "CRISPR-associated endonuclease Cas9, PI domain, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cas9_PI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049474": {"description": "Flagellar hook-associated protein 1, D3 domain", "go_ids": [], "go_terms": [], "name": "FlgK_D3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049475": {"description": "Mannanase, galactose-binding domain-like", "go_ids": [], "go_terms": [], "name": "Mann_GBD_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049476": {"description": "Single-stranded DNA-binding protein, BPT7", "go_ids": [], "go_terms": [], "name": "SBB_BPT7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049477": {"description": "Methylenetetrahydrofolate reductase", "go_ids": [], "go_terms": [], "name": "MTHFR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049478": {"description": "O-GlcNAcase BT_4395-like, post-catalytic domain", "go_ids": [], "go_terms": [], "name": "BT_4395-like_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049479": {"description": "Cytosolic arginine sensor for mTORC1 subunit 1/2, ACT-like", "go_ids": [], "go_terms": [], "name": "CASTOR1_ACT-like", "pathway_ids": ["R-RNO-9639288", "R-MMU-9639288", "R-HSA-9639288", "R-XTR-9639288", "R-BTA-9639288"], "pathways": ["R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-BTA-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR049480": {"description": "BVU_1015-like, N-terminal dimerisation-like domain", "go_ids": [], "go_terms": [], "name": "BVU_1015-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049481": {"description": "Survival Motor Neuron, Gemin2-binding domain", "go_ids": [], "go_terms": [], "name": "SMN_G2-BD", 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expression", "R-MMU-8876725:r:Protein methylation", "R-RNO-8876725:r:Protein methylation"], "type": "Domain"}, "IPR049483": {"description": "Fas-associated factor 1/2-like, UAS domain", "go_ids": [], "go_terms": [], "name": "FAF1_2-like_UAS", "pathway_ids": ["R-HSA-6798695", "R-XTR-8980692", "R-HSA-8980692", "R-MMU-8980692", "R-RNO-8980692", "R-BTA-8980692", "R-MMU-6798695", "R-BTA-6798695", "R-XTR-6798695", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-XTR-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-XTR-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR049484": {"description": "Transcriptional regulator Rv0078-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": 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"IPR049493": {"description": "vWA-MoxR associated protein middle region 18", "go_ids": [], "go_terms": [], "name": "VMAP-M18", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049496": {"description": "vWA-MoxR associated protein middle region 20", "go_ids": [], "go_terms": [], "name": "VMAP-M20", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049497": {"description": "Formin C, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ForC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049498": {"description": "Cmr1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cmr1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049499": {"description": "Dbr1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Dbr1_CTD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049500": {"description": "Peptidase M50B-like", "go_ids": [], "go_terms": [], "name": "Peptidase_M50B-like", "pathway_ids": [], "pathways": [], 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"pathways": [], "type": "Domain"}, "IPR049509": {"description": "DyP dimeric alpha+beta barrel domain", "go_ids": [], "go_terms": [], "name": "DyP_N", "pathway_ids": ["PWY-5466", "PWY-6824", "PWY-5461", "PWY-7445", "PWY-8249", "PWY-7214", "PWY-5469"], "pathways": ["PWY-5466:t:matairesinol biosynthesis", "PWY-6824:t:justicidin B biosynthesis", "PWY-5461:t:betanidin degradation", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-8249:t:xanthommatin biosynthesis", "PWY-7214:t:baicalein degradation (hydrogen peroxide detoxification)", "PWY-5469:t:sesamin biosynthesis"], "type": "Domain"}, "IPR049511": {"description": "Polyglycine hydrolase-like, tandem repeat", "go_ids": [], "go_terms": [], "name": "PGH-like_rpt", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Repeat"}, "IPR049512": {"description": "Double jelly roll-like domain", "go_ids": [], "go_terms": [], "name": "DJR-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049513": {"description": "Tetracyclin repressor-like 40, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR_C_40", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049514": {"description": "Filamentation induced by cAMP protein Fic-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Fic-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049516": {"description": "FAD-dependent protein, C-terminal domain-like", "go_ids": [], "go_terms": [], "name": "FAD-depend_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049517": {"description": "Acetophenone carboxylase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ACX-like_C", "pathway_ids": ["R-HSA-5578998", "R-RNO-174403", "R-HSA-174403", "R-MMU-174403", "R-SCE-174403", "R-SPO-174403"], "pathways": ["R-HSA-5578998:r:Defective OPLAH causes OPLAHD", "R-RNO-174403:r:Glutathione synthesis and recycling", "R-HSA-174403:r:Glutathione synthesis and recycling", "R-MMU-174403:r:Glutathione synthesis and recycling", "R-SCE-174403:r:Glutathione synthesis and recycling", "R-SPO-174403:r:Glutathione synthesis and recycling"], "type": "Domain"}, "IPR049518": {"description": "Ant venom peptides", "go_ids": [], "go_terms": [], "name": "Pilosulin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049519": {"description": "Type II restriction enzyme SmaI", "go_ids": ["GO:0009036"], "go_terms": ["GO:0009036:type II site-specific deoxyribonuclease activity:F"], "name": "SmaI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049521": {"description": "CIROZ, beta domain", "go_ids": [], "go_terms": [], "name": "CIROZ_b", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049522": {"description": "ART-PolyVal-like domain", "go_ids": [], "go_terms": [], "name": "ART-PolyVal_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049528": {"description": "Venom-like beta-defensin domain", "go_ids": [], "go_terms": [], "name": "DEFBL_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049529": {"description": "Metallothionein zym1-like", "go_ids": [], "go_terms": [], "name": "Zym1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049530": {"description": "EC042_2821-like Restriction Endonuclease-like domain", "go_ids": [], "go_terms": [], "name": "EC042_2821", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049531": {"description": "Antifreeze protein repeat", "go_ids": [], "go_terms": [], "name": "AFP_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR049532": {"description": "GTPase-associated protein 1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GAP1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049533": {"description": "TraN-like", "go_ids": [], "go_terms": [], "name": "TraN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049534": {"description": "Testis-expressed protein 13A/C/D, zinc finger domain", "go_ids": [], "go_terms": [], "name": "TEX13A/C/D_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049535": {"description": "Glycophorin A/B", "go_ids": [], "go_terms": [], "name": "GYPA_B", "pathway_ids": ["R-HSA-202733"], "pathways": ["R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR049536": {"description": "Properdin, thrombospondin type 1 repeat 0", "go_ids": [], "go_terms": [], "name": "CFP_TSR-0", "pathway_ids": ["R-HSA-6798695", "R-MMU-977606", "R-HSA-5173214", "R-HSA-977606", "R-HSA-173736", "R-MMU-174577", "R-MMU-5173214", "R-HSA-5083635", "R-HSA-174577", "R-MMU-6798695", "R-MMU-173736"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-173736:r:Alternative complement activation", "R-MMU-174577:r:Activation of C3 and C5", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-174577:r:Activation of C3 and C5", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-173736:r:Alternative complement activation"], "type": "Repeat"}, "IPR049537": {"description": "Antitoxin RelB-like", "go_ids": [], "go_terms": [], "name": "RelB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049538": {"description": "Plectin-like, spectrin-like repeat", "go_ids": [], "go_terms": [], "name": "PCN-like_spectrin-like_rpt", "pathway_ids": ["R-HSA-9013420", "R-RNO-446107", "R-HSA-2022090", "R-MMU-9013420", "R-HSA-9696270", "R-MMU-446107", "R-MMU-264870", "R-RNO-264870", "R-MMU-9013424", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-264870", "R-HSA-9013424", "R-HSA-446107", "R-MMU-9696273", "R-HSA-9696273", "R-HSA-9696264"], "pathways": ["R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-446107:r:Type I 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[], "name": "Spt6-like_S1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049541": {"description": "Transcription regulator P7-like", "go_ids": [], "go_terms": [], "name": "P7-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049542": {"description": "TopBP1-like, BRCT0 domain", "go_ids": [], "go_terms": [], "name": "TopBP1-like_BRCT0", "pathway_ids": ["R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-5693616", "R-HSA-69473", "R-HSA-5685938", "R-MMU-6804756", "R-MMU-5685938", "R-MMU-5693607"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Domain"}, "IPR049543": {"description": "Transcription factor tau 138 kDa subunit, extended winged helix", "go_ids": [], "go_terms": [], "name": "WHD_TFC3", "pathway_ids": ["R-SPO-76061", "R-SCE-76066", "R-SPO-76066", "R-SCE-76061"], "pathways": ["R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR049544": {"description": "Sulfocyanin-like, C-terminal", "go_ids": [], "go_terms": [], "name": "SoxE-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049545": {"description": "Glutamyl-tRNA amidotransferase complex subunit Gta3 domain", "go_ids": [], "go_terms": [], "name": "Gta3_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049546": {"description": "WD repeat-containing protein 54, beta-propeller", "go_ids": [], "go_terms": [], "name": "WDR54_beta_prop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049547": {"description": "WD repeat-containing protein 93 beta-propeller", "go_ids": [], "go_terms": [], "name": "WDR93_beta-prop", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR049548": {"description": "E3 ubiquitin-protein ligase Sina-like, RING finger", "go_ids": [], "go_terms": [], "name": "Sina-like_RING", "pathway_ids": ["PWY-7511", "R-DME-983168", "R-DRE-5689880", "R-HSA-5689880", "R-HSA-977225", "R-DDI-937072", "R-HSA-373752", "R-HSA-983168", "R-CEL-983168", "R-RNO-5689880", "R-DDI-450321", "R-DDI-937042", "R-DDI-9020702", "R-MMU-5689880", "R-DDI-450302", "R-DRE-983168", "R-CEL-5689880", "R-DDI-975163", "R-MMU-983168", "R-RNO-983168", "R-DDI-5689880", "R-DME-5689880"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-977225:r:Amyloid fiber formation", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DDI-9020702:r:Interleukin-1 signaling", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-5689880:r:Ub-specific processing proteases", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR049549": {"description": "26S proteasome regulatory subunit RPN7/PSMD6, C-terminal helix", "go_ids": [], "go_terms": [], "name": "RPN7_PSMD6_C", "pathway_ids": ["R-MMU-450408", "R-HSA-174178", "R-HSA-9020702", "R-HSA-9604323", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-HSA-8951664", "R-HSA-9010553", "R-MMU-174154", "R-MMU-69017", "R-HSA-75815", "R-CEL-195253", "R-CEL-8941858", "R-MMU-9020702", "R-DME-5658442", "R-MMU-8948751", "R-DME-8948751", "R-MMU-69481", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-CEL-1234176", "R-DDI-9929491", "R-MMU-5668541", "R-DME-2467813", "R-HSA-8854050", "R-DME-5676590", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-HSA-1234176", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-DDI-174084", "R-MMU-68867", "R-DME-4641257", "R-DME-432524", "R-MMU-9932298", "R-DME-209461", "R-MMU-1234176", "R-MMU-4641258", "R-DME-75815", "R-DDI-4641258", "R-HSA-180534", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-CEL-8948751", "R-MMU-5687128", "R-MMU-9766229", "R-DME-5358346", "R-HSA-174154", "R-DDI-187577", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-DDI-382556", "R-MMU-187577", "R-HSA-2467813", "R-DME-202424", "R-DME-187577", "R-MMU-8852276", "R-SCE-6798695", "R-MMU-68949", "R-CEL-9907900", "R-HSA-9824272", "R-MMU-174178", "R-CEL-983168", "R-MMU-349425", "R-MMU-8939236", "R-CEL-8854050", "R-HSA-9907900", "R-DME-350562", "R-DME-174084", "R-DME-9907900", "R-DDI-5689603", "R-CEL-75815", "R-DDI-69601", "R-DDI-2467813", "R-DME-9929491", "R-MMU-9762114", "R-HSA-9762114", "R-DDI-5689880", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-MMU-382556", "R-HSA-5610780", "R-DME-209360", "R-DDI-5687128", "R-CEL-9755511", "R-DME-6798695", "R-DDI-9907900", "R-SCE-1236978", "R-DME-8939236", "R-MMU-1169091", "R-DME-174184", "R-DME-432626", "R-MMU-5607761", "R-MMU-5676590", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-MMU-174184", "R-MMU-8939902", "R-DME-174178", "R-DME-9932298", "R-DME-9020702", "R-CEL-9762114", "R-HSA-8939236", "R-HSA-5358346", "R-CEL-8951664", "R-CEL-4641257", "R-DDI-8854050", "R-HSA-6798695", "R-SPO-350562", "R-DME-5689880", "R-MMU-5632684", "R-SPO-9907900", "R-MMU-5607764", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-DME-8951664", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-DDI-1236978", "R-DDI-5632684", "R-DDI-8951664", "R-MMU-8951664", "R-DME-8939902", "R-CEL-382556", "R-CEL-5689603", "R-HSA-4641257", "R-MMU-9929491", "R-HSA-174113", "R-MMU-9929356", "R-DME-4608870", "R-SCE-5668541", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-HSA-69481", "R-DME-9762114", "R-CEL-4641258", "R-DDI-5658442", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-HSA-9755511", "R-HSA-4641258", "R-CEL-9929491", "R-SPO-5689603", "R-DME-9755511", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-HSA-1169091", "R-CEL-69017", "R-HSA-4608870", "R-HSA-5658442", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-DME-450408", "R-DME-8941858", "R-SPO-6798695", "R-HSA-187577", "R-MMU-5610780", "R-DME-9954709", "R-DME-1169091", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-9954709", "R-DDI-75815", "R-MMU-350562", "R-MMU-69601", "R-DME-195253", "R-HSA-2871837", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-DME-5607761", "R-MMU-5658442", "R-MMU-5689603", "R-DME-5689603", "R-HSA-174084", "R-DME-216167", "R-MMU-4608870", "R-HSA-5607764", "R-DME-68949", "R-DDI-69017", "R-CEL-1236978", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-HSA-5687128", "R-DDI-349425", "R-HSA-202424", "R-HSA-69017", "R-DME-5632684", "R-DME-432395", "R-MMU-983168", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-HSA-350562", "R-DDI-174178", "R-DDI-174154", "R-DME-68867"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-9907900:r:Proteasome assembly", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-DME-9020702:r:Interleukin-1 signaling", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-CEL-4641257:r:Degradation of AXIN", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CEL-5689603:r:UCH proteinases", "R-HSA-4641257:r:Degradation of AXIN", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-4641258:r:Degradation of DVL", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-5689603:r:UCH proteinases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5689603:r:UCH proteinases", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-68949:r:Orc1 removal from chromatin", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-68949:r:Orc1 removal from chromatin", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR049550": {"description": "RecBCD enzyme subunit RecD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RecD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049551": {"description": "Polyketide synthase, dehydratase domain, C-terminal", "go_ids": [], "go_terms": [], "name": "PKS_DH_C", "pathway_ids": ["PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-DDI-199220", "R-MTU-9635470", "R-DDI-75105", "PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543"], "pathways": ["PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis"], "type": "Domain"}, "IPR049552": {"description": "Polyketide synthase, dehydratase domain, N-terminal", "go_ids": [], "go_terms": [], "name": "PKS_DH_N", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-DDI-75105", "R-HSA-75105", "R-DDI-199220", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR049553": {"description": "Cyclic-di-AMP phosphodiesterase GdpP-like, PAS domain", "go_ids": [], "go_terms": [], "name": "GdpP-like_PAS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049554": {"description": "DNMT3, ADD domain, PHD zinc finger", "go_ids": [], "go_terms": [], "name": "DNMT3_ADD_PHD", "pathway_ids": ["R-HSA-4655427", "R-RNO-212300", "R-HSA-212300", "R-MMU-4655427", "R-HSA-9845323", "R-RNO-3214858", "R-HSA-427413", "R-MMU-212300", "R-HSA-5334118", "R-HSA-3214858", "R-MMU-3214858", "R-HSA-9710421"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-RNO-212300:r:PRC2 methylates histones and DNA", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-MMU-4655427:r:SUMOylation of DNA methylation proteins", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-5334118:r:DNA methylation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-HSA-9710421:r:Defective pyroptosis"], "type": "Domain"}, "IPR049560": {"description": "SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core", "go_ids": [], "go_terms": [], "name": "MeTrfase_RsmB-F_NOP2_cat", "pathway_ids": ["R-HSA-6782315", "R-HSA-6793080", "R-HSA-6790901", "R-HSA-8869496"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-HSA-8869496:r:TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "type": "Domain"}, "IPR049561": {"description": "NOL1/NOP2/NSUN 5/7, ferredoxin-like domain", "go_ids": [], "go_terms": [], "name": "NSUN5_7_fdxn-like", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR049562": {"description": "Solute carrier family 25 member 33/36-like", "go_ids": ["GO:0015218"], "go_terms": ["GO:0015218:pyrimidine nucleotide transmembrane transporter activity:F"], "name": "SLC25A33/36-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049563": {"description": "Tricarboxylate transport protein-like", "go_ids": [], "go_terms": [], "name": "TXTP-like", "pathway_ids": ["R-SPO-428643", "R-CEL-428643", "R-RNO-428643", "R-SCE-428643", "R-HSA-428643", "R-DRE-428643", "R-MMU-428643"], "pathways": ["R-SPO-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-CEL-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-RNO-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-SCE-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-HSA-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-DRE-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-MMU-428643:r:Organic anion transport by SLC5/17/25 transporters"], "type": "Family"}, "IPR049564": {"description": "DsbA-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DsbA-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049565": {"description": "Bd2520-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Bd2520-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049566": {"description": "WDR59/RTC1-like, RING zinc finger domain", "go_ids": [], "go_terms": [], "name": "WDR59_RTC1-like_RING_Znf", "pathway_ids": ["R-MMU-9639288", "R-DDI-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR049567": {"description": "GATOR complex protein WDR59-like", "go_ids": [], "go_terms": [], "name": "WDR59-like", "pathway_ids": ["R-MMU-9639288", "R-DDI-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR049585": {"description": "CdiI immunity protein EcoliA0-like", "go_ids": [], "go_terms": [], "name": "CdiI_EcoliA0-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049586": {"description": "YciY", "go_ids": [], "go_terms": [], "name": "YciY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049596": {"description": "YlcG-like", "go_ids": [], "go_terms": [], "name": "YlcG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049597": {"description": "Divisome-associated membrane protein Blr", "go_ids": [], "go_terms": [], "name": "Blr-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049598": {"description": "Heterocyst commitment protein HetP-like", "go_ids": [], "go_terms": [], "name": "HetP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049599": {"description": "Conjugal transfer protein TraX", "go_ids": [], "go_terms": [], "name": "TraX-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049606": {"description": "UsfY-like", "go_ids": [], "go_terms": [], "name": "UsfY-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049607": {"description": "YrbN-like", "go_ids": [], "go_terms": [], "name": "YrbN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049608": {"description": "Conjugal transfer protein TraP-like", "go_ids": [], "go_terms": [], "name": "TraP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049610": {"description": "Low-complexity tail membrane protein-like", "go_ids": [], "go_terms": [], "name": "LCTMP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049611": {"description": "Stress response membrane protein YncL", "go_ids": [], "go_terms": [], "name": "YncL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049615": {"description": "BH0509-like", "go_ids": [], "go_terms": [], "name": "BH0509-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049616": {"description": "Phenylalanyl--tRNA ligase operon leader peptide PheM", "go_ids": [], "go_terms": [], "name": "PheM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049622": {"description": "Dihydroorotate dehydrogenase class I, catalytic", "go_ids": [], "go_terms": [], "name": "Dihydroorotate_DH_I", "pathway_ids": ["PWY-7791"], "pathways": ["PWY-7791:t:UMP biosynthesis III"], "type": "Domain"}, "IPR049623": {"description": "Phenylacetate--CoA ligase PaaK, proteobacteria/actinomycetes", "go_ids": [], "go_terms": [], "name": "PA_CoA_lig_proteobact_actino", "pathway_ids": ["PWY-6318", "PWY-7716", "PWY-1341"], "pathways": ["PWY-6318:t:L-phenylalanine degradation IV (mammalian, via side chain)", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-1341:t:phenylacetate degradation II (anaerobic)"], "type": "Family"}, "IPR049624": {"description": "Forkhead box protein N1/4", "go_ids": [], "go_terms": [], "name": "FOXN1_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049625": {"description": "Glycosyltransferase 61, catalytic domain", "go_ids": ["GO:0016757"], "go_terms": ["GO:0016757:glycosyltransferase activity:F"], "name": "Glyco_transf_61_cat", "pathway_ids": ["R-MMU-8932505", "R-GGA-8932505", "R-HSA-8932505", "R-XTR-8932505", "R-DRE-8932505", "R-RNO-8932505", "R-BTA-8932505"], "pathways": ["R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-GGA-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-XTR-8932505:r:DAG1 core M3 glycosylations", "R-DRE-8932505:r:DAG1 core M3 glycosylations", "R-RNO-8932505:r:DAG1 core M3 glycosylations", "R-BTA-8932505:r:DAG1 core M3 glycosylations"], "type": "Domain"}, "IPR049627": {"description": "E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8", "go_ids": ["GO:0061630"], "go_terms": ["GO:0061630:ubiquitin protein ligase activity:F"], "name": "SLX8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049634": {"description": "FADD, vertebrates", "go_ids": [], "go_terms": [], "name": "FADD_vert", "pathway_ids": ["R-BTA-69416", "R-HSA-5218900", "R-BTA-5357786", "R-MMU-75157", "R-BTA-140534", "R-HSA-5357905", "R-BTA-5675482", "R-HSA-9693928", "R-MMU-5218900", "R-MMU-3371378", "R-MMU-140534", "R-MMU-5357786", "R-BTA-5357905", "R-BTA-5218900", "R-BTA-75157", "R-HSA-5675482", "R-MMU-5675482", "R-HSA-75158", "R-HSA-5357786", "R-HSA-69416", "R-MMU-75158", "R-HSA-5213460", "R-MMU-69416", "R-HSA-2562578", "R-HSA-75157", "R-HSA-933543", "R-MMU-5357905", "R-BTA-3371378", "R-MMU-2562578", "R-HSA-140534", "R-HSA-3371378", "R-HSA-9013957", "R-BTA-2562578"], "pathways": ["R-BTA-69416:r:Dimerization of procaspase-8", "R-HSA-5218900:r:CASP8 activity is inhibited", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-75157:r:FasL/ CD95L signaling", "R-BTA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-HSA-9693928:r:Defective RIPK1-mediated regulated necrosis", "R-MMU-5218900:r:CASP8 activity is inhibited", "R-MMU-3371378:r:Regulation by c-FLIP", "R-MMU-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-5218900:r:CASP8 activity is inhibited", "R-BTA-75157:r:FasL/ CD95L signaling", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-HSA-75158:r:TRAIL signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-69416:r:Dimerization of procaspase-8", "R-MMU-75158:r:TRAIL signaling", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-69416:r:Dimerization of procaspase-8", "R-HSA-2562578:r:TRIF-mediated programmed cell death", "R-HSA-75157:r:FasL/ CD95L signaling", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-3371378:r:Regulation by c-FLIP", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-HSA-3371378:r:Regulation by c-FLIP", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-BTA-2562578:r:TRIF-mediated programmed cell death"], "type": "Family"}, "IPR049637": {"description": "Mitogen-activated protein kinase kinase kinase 7", "go_ids": ["GO:0007165", "GO:0004709", "GO:0000287"], "go_terms": ["GO:0007165:signal transduction:P", "GO:0004709:MAP kinase kinase kinase activity:F", "GO:0000287:magnesium ion binding:F"], "name": "MAP3K7", "pathway_ids": ["R-HSA-9020702", "R-RNO-9020702", "R-HSA-168638", "R-HSA-937042", "R-BTA-5689880", "R-BTA-5357956", "R-BTA-202424", "R-HSA-9705671", "R-HSA-5689880", "R-RNO-937072", "R-MMU-450302", "R-MMU-5607764", "R-MMU-4086398", 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"PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR049830": {"description": "NADP-reducing hydrogenase subunit HndD", "go_ids": [], "go_terms": [], "name": "HndD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049831": {"description": "UGSC-motif contining selenoprotein", "go_ids": [], "go_terms": [], "name": "UGSC_seleno", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049832": {"description": "BREX system serine/threonine kinase PglW", "go_ids": [], "go_terms": [], "name": "BREX_PglW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049833": {"description": "Small membrane protein KPN01023-like", "go_ids": [], "go_terms": [], "name": "KPN01023-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049834": {"description": "D-ornithine 4,5-aminomutase subunit beta-like", "go_ids": [], "go_terms": [], "name": "OraE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049835": {"description": "Sensor histidine kinase RppB", "go_ids": [], "go_terms": [], "name": "RppB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049836": {"description": "Peptidoglycan endopeptidase RipA", "go_ids": [], "go_terms": [], "name": "RipA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049837": {"description": "Transposon-encoded protein TnpC-like", "go_ids": [], "go_terms": [], "name": "TnpC_reg-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049838": {"description": "D-xylose 1-dehydrogenase XacA-like", "go_ids": [], "go_terms": [], "name": "XacA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049839": {"description": "Lmo0850-like", "go_ids": [], "go_terms": [], "name": "Lmo0850-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049840": {"description": "FlgM-associated protein DVU0524-like", "go_ids": [], "go_terms": [], "name": "DVU0524-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049841": {"description": "VPA1267-like", "go_ids": [], "go_terms": [], "name": "VPA1267-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049842": {"description": "3-dehydro-scyllo-inosose hydrolase IolN", "go_ids": [], "go_terms": [], "name": "Diketo_inos_hlase_IolN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049843": {"description": "Zinc piracy TonB-dependent receptor ZnuD", "go_ids": [], "go_terms": [], "name": "ZnuD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049844": {"description": "RsaX20-like", "go_ids": [], "go_terms": [], "name": "RsaX20-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049845": {"description": "Conjugative relaxosome accessory protein SAG1252-like", "go_ids": [], "go_terms": [], "name": "Tn5252_Orf10-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049846": {"description": "NF038105-like", "go_ids": [], "go_terms": [], "name": "NF038105-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049847": {"description": "CrpP-related", "go_ids": [], "go_terms": [], "name": "CrpP-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049848": {"description": "Type IVa secretion system protein TapY2-like", "go_ids": [], "go_terms": [], "name": "TapY2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049849": {"description": "LPFR-motif containing-like", "go_ids": [], "go_terms": [], "name": "LPFR_strepto", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049851": {"description": "Holdfast attachment protein HfaA", "go_ids": [], "go_terms": [], "name": "Holdfast_HfaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049852": {"description": "YpfM-like", "go_ids": [], "go_terms": [], "name": "YpfM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049853": {"description": "Ornithine uptake porin CarO", "go_ids": [], "go_terms": [], "name": "CarO_OMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049854": {"description": "Sigma(X)-activator ComW", "go_ids": [], "go_terms": [], "name": "SigmaX_act_ComW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049857": {"description": "Outer membrane lipoprotein Omp10-like", "go_ids": [], "go_terms": [], "name": "Omp10-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049858": {"description": "Anti-CRISPR type II subtype A6-like", "go_ids": [], "go_terms": [], "name": "AcrIIA6-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049859": {"description": "HTH-type transcriptional regulator LrpA1", "go_ids": [], "go_terms": [], "name": "LrpA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049860": {"description": "Holdfast anchor protein HfaD", "go_ids": [], "go_terms": [], "name": "Holdfast_HfaD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049861": {"description": "Holdfast anchoring protein HfaB", "go_ids": [], "go_terms": [], "name": "Holdfast_HfaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049862": {"description": "Stress response protein AzuC", "go_ids": [], "go_terms": [], "name": "AzuC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049863": {"description": "Ribonuclease HI, halobacteria", "go_ids": [], "go_terms": [], "name": "RnhA-like_halobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049864": {"description": "Phosphomevalonate decarboxylase", "go_ids": [], "go_terms": [], "name": "MvaD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049865": {"description": "Putative surface-exposed virulence protein BigA", "go_ids": [], "go_terms": [], "name": "BigA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049867": {"description": "Nickel-binding protein HpnL", "go_ids": [], "go_terms": [], "name": "HpnL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049868": {"description": "Type V CRISPR-associated protein Cas12k", "go_ids": [], "go_terms": [], "name": "V_Cas12k", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049869": {"description": "Peptide resistance ABC transporter activity modulator VraH", "go_ids": [], "go_terms": [], "name": "VraH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049875": {"description": "Type II secretion system minor pseudopilin GspH", "go_ids": ["GO:0015628", "GO:0015627"], "go_terms": ["GO:0015628:protein secretion by the type II secretion system:P", "GO:0015627:type II protein secretion system complex:C"], "name": "TypeII_GspH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049883": {"description": "NOTCH1, EGF-like calcium-binding domain", "go_ids": [], "go_terms": [], "name": "NOTCH1_EGF-like", "pathway_ids": ["R-MMU-8856828", "R-HSA-373080", "R-HSA-2243919", "R-MMU-180336", "R-HSA-9604323", "R-DRE-186797", "R-MMU-6811558", "R-HSA-3000178", "R-HSA-140837", "R-HSA-9918485", "R-RNO-9009391", "R-RNO-140875", "R-MMU-9009391", "R-CEL-1566948", "R-DME-1912420", "R-GGA-8866376", "R-MMU-166662", "R-RNO-8863795", "R-RNO-140837", "R-MMU-975634", "R-HSA-209968", "R-BTA-8957275", "R-MMU-1912420", "R-HSA-5083630", "R-CEL-2129379", "R-HSA-8863795", "R-HSA-9818030", "R-RNO-6811558", "R-RNO-8847993", "R-HSA-2979096", "R-MMU-202733", "R-RNO-1963642", "R-HSA-3359462", "R-MMU-1236394", "R-RNO-1912420", "R-HSA-166663", "R-HSA-9013507", "R-HSA-2691232", "R-MMU-1566948", "R-MMU-5673001", "R-HSA-2122947", "R-RNO-8964046", "R-RNO-212718", "R-HSA-1474228", "R-HSA-182971", "R-BTA-1566948", "R-CEL-2979096", "R-DRE-2979096", "R-CEL-2214320", "R-BTA-1474228", "R-RNO-159763", "R-XTR-9013507", "R-RNO-8964011", "R-HSA-5637810", "R-DRE-5362798", "R-HSA-159740", "R-RNO-2855086", "R-HSA-2660826", "R-MMU-350054", "R-MMU-9758890", "R-MMU-179812", "R-MMU-1963642", "R-MMU-216083", "R-MMU-209968", "R-DME-9013700", "R-MMU-1250196", "R-HSA-9793380", "R-HSA-2644606", "R-RNO-373080", "R-CEL-2173789", "R-HSA-179812", "R-MMU-186797", "R-RNO-6798695", "R-HSA-5638303", "R-HSA-9705671", "R-RNO-216083", "R-HSA-8941856", "R-MMU-2122947", "R-RNO-1257604", "R-XTR-8941856", "R-HSA-9665348", "R-XTR-2122948", "R-MMU-373080", "R-BTA-159782", "R-HSA-9824272", "R-XTR-1912420", "R-HSA-114608", "R-HSA-196791", "R-MMU-8847993", "R-HSA-9013700", "R-MMU-9013507", "R-MMU-8964038", "R-HSA-3359463", "R-HSA-1963642", "R-MMU-159763", "R-HSA-1250196", "R-RNO-8856828", "R-RNO-177929", "R-BTA-2129379", "R-RNO-2173789", "R-HSA-159763", "R-BTA-8856828", "R-HSA-1912420", "R-HSA-1963640", "R-MMU-3000157", "R-MMU-2173789", "R-HSA-2129379", "R-BTA-140875", "R-HSA-210744", "R-HSA-8964026", "R-MMU-1227986", "R-RNO-1227986", "R-HSA-6785631", "R-MMU-8964026", "R-MMU-1257604", "R-MMU-9017802", "R-HSA-9758890", "R-HSA-9634638", "R-HSA-140875", "R-DME-2243919", "R-HSA-350054", "R-HSA-180336", "R-MMU-140875", "R-DME-1474228", "R-HSA-8866427", "R-HSA-9009391", "R-MMU-212718", "R-GGA-8866427", "R-MMU-1650814", "R-HSA-8856825", "R-MMU-159782", "R-MMU-5362798", "R-RNO-180336", "R-HSA-166662", "R-BTA-216083", "R-HSA-1912399", "R-HSA-8964038", "R-HSA-975634", "R-HSA-202733", "R-HSA-186797", "R-HSA-6798695", "R-MMU-182971", "R-MMU-6785631", "R-XTR-2979096", "R-DME-9604323", "R-BTA-8964026", "R-BTA-140837", "R-HSA-159782", "R-HSA-180292", "R-MMU-8964046", "R-MMU-159740", "R-HSA-8856828", "R-RNO-8866376", "R-CEL-6798695", "R-HSA-2168880", "R-HSA-432142", "R-MMU-2122948", "R-RNO-3000157", "R-RNO-8964026", "R-HSA-9818749", "R-BTA-2173789", "R-HSA-9927418", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-2855086", "R-HSA-1650814", "R-MMU-2243919", "R-MMU-2214320", "R-MMU-432142", "R-RNO-350054", "R-RNO-9758890", "R-DME-2214320", "R-RNO-202733", "R-MMU-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-177929", "R-HSA-9664565", "R-RNO-5673001", "R-RNO-159740", "R-RNO-8866427", "R-HSA-381426", "R-MMU-9013700", "R-HSA-212718", "R-MMU-1474228", "R-HSA-2173789", "R-MMU-2168880", "R-CEL-216083", "R-RNO-179812", "R-MMU-446203", "R-HSA-9665686", "R-DME-1650814", "R-MMU-180292", "R-HSA-8847993", "R-HSA-9830364", "R-RNO-2168880", "R-MMU-140837", "R-RNO-446203", "R-RNO-9013507", "R-HSA-2219530", "R-RNO-1566948", "R-MMU-9604323", "R-HSA-5673001", "R-HSA-6811558", "R-RNO-381426", "R-RNO-196791", "R-HSA-9013695", "R-HSA-2644607", "R-MMU-8866427", "R-HSA-9911233", "R-MMU-6798695", "R-HSA-9758881", "R-HSA-1257604", "R-BTA-159763", "R-XTR-9017802", "R-CEL-1650814", "R-MMU-114608", "R-HSA-8964011", "R-MMU-8863795", "R-RNO-6785631", "R-HSA-9725554", "R-HSA-2122948", "R-MMU-8856825", "R-HSA-3000157", "R-RNO-9017802", "R-RNO-159782", "R-RNO-166662", "R-MMU-2855086", "R-HSA-1566948", "R-HSA-1251932", "R-MMU-3000480", "R-RNO-2129379", "R-RNO-114608", "R-HSA-8964046", "R-XTR-2197563", "R-BTA-202733", "R-HSA-1912408", "R-HSA-9017802", "R-CEL-1474228", "R-BTA-114608", "R-HSA-5362798", "R-RNO-9758881", "R-HSA-977606", "R-RNO-8957275", "R-HSA-1236382", "R-BTA-381426", "R-RNO-975634", "R-BTA-159740", "R-RNO-209968", "R-HSA-2214320", "R-HSA-8963896", "R-HSA-9013508", "R-RNO-8856825", "R-HSA-446203", "R-HSA-216083", "R-HSA-428542", "R-HSA-9927432", "R-HSA-2894862", "R-HSA-1227986", "R-HSA-9937080", "R-RNO-180292", "R-HSA-1236394", "R-HSA-9830674", "R-BTA-8856825", "R-MMU-8963896", "R-BTA-8964038", "R-MMU-8866376", "R-RNO-1236394", "R-MMU-8941856", "R-HSA-8957275", "R-RNO-1250196", "R-RNO-182971", "R-HSA-8866376", "R-HSA-2197563", "R-MMU-2129379", "R-MMU-177929"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-HSA-2243919:r:Crosslinking of collagen fibrils", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-DRE-186797:r:Signaling by PDGF", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-1566948:r:Elastic fibre formation", "R-DME-1912420:r:Pre-NOTCH Processing in Golgi", "R-GGA-8866376:r:Reelin signalling pathway", "R-MMU-166662:r:Lectin pathway of complement activation", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-975634:r:Retinoid metabolism and transport", "R-HSA-209968:r:Thyroxine biosynthesis", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-5083630:r:Defective LFNG causes SCDO3", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-3359462:r:Defective AMN causes MGA1", "R-MMU-1236394:r:Signaling by ERBB4", "R-RNO-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-MMU-1566948:r:Elastic fibre formation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-RNO-8964046:r:VLDL clearance", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-182971:r:EGFR downregulation", "R-BTA-1566948:r:Elastic fibre formation", "R-CEL-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DRE-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-CEL-2214320:r:Anchoring fibril formation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-XTR-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-8964011:r:HDL clearance", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-9758890:r:Transport of RCbl within the body", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-209968:r:Thyroxine biosynthesis", "R-DME-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-RNO-373080:r:Class B/2 (Secretin family receptors)", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-MMU-186797:r:Signaling by PDGF", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-216083:r:Integrin cell surface interactions", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-XTR-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-XTR-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-BTA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-9824272:r:Somitogenesis", "R-XTR-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-114608:r:Platelet degranulation", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-8964038:r:LDL clearance", "R-HSA-3359463:r:Defective CUBN causes MGA1", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-177929:r:Signaling by EGFR", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-1227986:r:Signaling by ERBB2", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8964026:r:Chylomicron clearance", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9758890:r:Transport of RCbl within the body", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-DME-2243919:r:Crosslinking of collagen fibrils", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-HSA-166662:r:Lectin pathway of complement activation", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "R-HSA-8964038:r:LDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-186797:r:Signaling by PDGF", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-182971:r:EGFR downregulation", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-XTR-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DME-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-8964026:r:Chylomicron clearance", "R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-8964046:r:VLDL clearance", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8866376:r:Reelin signalling pathway", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-432142:r:Platelet sensitization by LDL", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-3000157:r:Laminin interactions", "R-RNO-8964026:r:Chylomicron clearance", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-2243919:r:Crosslinking of collagen fibrils", "R-MMU-2214320:r:Anchoring fibril formation", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-RNO-9758890:r:Transport of RCbl within the body", "R-DME-2214320:r:Anchoring fibril formation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-CEL-216083:r:Integrin cell surface interactions", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DME-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-446203:r:Asparagine N-linked glycosylation", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-RNO-1566948:r:Elastic fibre formation", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-HSA-9911233:r:Expression of NOTCH2NL genes", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-XTR-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-114608:r:Platelet degranulation", "R-HSA-8964011:r:HDL clearance", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000157:r:Laminin interactions", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-RNO-166662:r:Lectin pathway of complement activation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-1566948:r:Elastic fibre formation", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-RNO-114608:r:Platelet degranulation", "R-HSA-8964046:r:VLDL clearance", "R-XTR-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-9017802:r:Noncanonical activation of NOTCH3", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-BTA-114608:r:Platelet degranulation", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-975634:r:Retinoid metabolism and transport", "R-BTA-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-209968:r:Thyroxine biosynthesis", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8963896:r:HDL assembly", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-9830674:r:Formation of the ureteric bud", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8963896:r:HDL assembly", "R-BTA-8964038:r:LDL clearance", "R-MMU-8866376:r:Reelin signalling pathway", "R-RNO-1236394:r:Signaling by ERBB4", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-182971:r:EGFR downregulation", "R-HSA-8866376:r:Reelin signalling pathway", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-MMU-177929:r:Signaling by EGFR"], "type": "Domain"}, "IPR049884": {"description": "Scytalone dehydratase-like", "go_ids": [], "go_terms": [], "name": "Scytalone_dh", "pathway_ids": ["PWY-7045", "PWY-8319", "PWY-7811", "PWY-6322", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7814", "PWY-6627", "PWY-6946", "PWY-6945", "PWY-7188", "PWY-5780", "PWY-7897", "PWY-7275", "PWY-5367", "PWY-8152", "PWY-8029", "PWY-6948", "PWY-8134", "PWY-7610", "PWY-7695", "PWY-7354", "PWY-8335", "PWY-6944", "PWY-7547", "PWY-8012", "PWY-2229", "PWY-5793", "PWY-7352", "PWY-2467", "PWY-8044", "PWY-6602", "PWY-6679", "PWY-7757", "PWY-7510", "PWY-5979", "PWY-721", "PWY-5644", "PWY-5408", "PWY-7821", "PWY-7189", "PWY-5410", "PWY-7613", "PWYG-321", "PWY-5061", "PWY-6721", "PWY-6672", "PWY-5409", "PWY-6749", "PWY-7428", "PWY-8151"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-8319:t:NiFe(CO)(CN)2 cofactor biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7188:t:orientin and isoorientin biosynthesis I", "PWY-5780:t:hypericin biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-7275:t:L-homophenylalanine biosynthesis", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-8134:t:bile acid 7beta-dehydroxylation", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-8335:t:plasmalogen biosynthesis II (anaerobic)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7547:t:prodigiosin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-2229:t:superpathway of pterocarpan biosynthesis (via formononetin)", "PWY-5793:t:maysin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-2467:t:(+)-pisatin biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6602:t:naringenin C-glucosylation", "PWY-6679:t:jadomycin biosynthesis", "PWY-7757:t:bisphenol A degradation", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-721:t:3-methylquinoline degradation", "PWY-5644:t:4-nitrotoluene degradation II", "PWY-5408:t:9-lipoxygenase and 9-hydroperoxide lyase pathway", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7189:t:pinocembrin C-glucosylation", "PWY-5410:t:traumatin and (Z)-3-hexen-1-yl acetate biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5061:t:6,7,4'-trihydroxyisoflavone biosynthesis", "PWY-6721:t:sangivamycin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-5409:t:divinyl ether biosynthesis II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7428:t:2-chloroacrylate degradation II", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)"], "type": "Domain"}, "IPR049885": {"description": "Microtubule cross-linking factor 1-3", "go_ids": [], "go_terms": [], "name": "MTCL1-3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049886": {"description": "CFI box-CTERM domain", "go_ids": [], "go_terms": [], "name": "CFI_box_CTERM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049887": {"description": "CmeU-like", "go_ids": [], "go_terms": [], "name": "CmeU-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049888": {"description": "Highly acidic protein", "go_ids": [], "go_terms": [], "name": "Highly_acidic", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049889": {"description": "Type I-Fv CRISPR-associated protein Cas7fv-like", "go_ids": [], "go_terms": [], "name": "Cas7fv-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049890": {"description": "Variant surface antigen A-F-like, signal domain", "go_ids": [], "go_terms": [], "name": "VlpA-F-like_signal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049891": {"description": "Cyanobacterial tandem bacteriocin", "go_ids": [], "go_terms": [], "name": "CTB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049892": {"description": "Auxiliary Activity family 9", "go_ids": [], "go_terms": [], "name": "AA9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049893": {"description": "Bvu_2165-like, IHF-HU-like DNA-binding domain", "go_ids": [], "go_terms": [], "name": "Bvu_2165-like_IHF-HU-DNA_bdg", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049897": {"description": "Latexin-type cystatin domain", "go_ids": [], "go_terms": [], "name": "CYSTATIN_LXN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049902": {"description": "Fusexin 1", "go_ids": [], "go_terms": [], "name": "Fsx1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049906": {"description": "LxmA-like, leader domain", "go_ids": [], "go_terms": [], "name": "LxmA-like_leader", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049907": {"description": "Phe operon leader peptide", "go_ids": [], "go_terms": [], "name": "PheL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049908": {"description": "Multiple cyclophane triceptide AmcA, group 3a", "go_ids": [], "go_terms": [], "name": "AmcA_3a", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049910": {"description": "HetZ-related", "go_ids": [], "go_terms": [], "name": "HetZ-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049911": {"description": "Host nuclease inhibitor GamL-like", "go_ids": [], "go_terms": [], "name": "GamL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049912": {"description": "CRESS-DNA virus replication initiator protein, endonuclease domain", "go_ids": ["GO:0006260"], "go_terms": ["GO:0006260:DNA replication:P"], "name": "CRESS_DNA_REP", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR049914": {"description": "PHD finger-containing protein 1-3/5-6", "go_ids": ["GO:0034244", "GO:0140566"], "go_terms": ["GO:0034244:negative regulation of transcription elongation by RNA polymerase II:P", "GO:0140566:histone reader activity:F"], "name": "PHD1-3/5-6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049915": {"description": "Telomerase reverse transcriptase, TEN domain", "go_ids": [], "go_terms": [], "name": "TERT_TEN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049916": {"description": "WD repeat-containing protein 72-like", "go_ids": [], "go_terms": [], "name": "WDR72-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049917": {"description": "Excisionase Xis", "go_ids": [], "go_terms": [], "name": "Xis_Gifsy_1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049918": {"description": "HxsD-related", "go_ids": [], "go_terms": [], "name": "HxsD-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049919": {"description": "Type 4 adapter protein IcmW", "go_ids": [], "go_terms": [], "name": "IcmW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049920": {"description": "Probable CBASS effector molecule IK1_05631-like", "go_ids": [], "go_terms": [], "name": "IK1_05631-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049921": {"description": "Type 4 apparatus protein DotM-llike", "go_ids": [], "go_terms": [], "name": "DotM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049922": {"description": "Glycosyl-hydrolase 114-associated domain", "go_ids": [], "go_terms": [], "name": "GH114_assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049923": {"description": "Avirulence protein", "go_ids": [], "go_terms": [], "name": "AvrXv3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049924": {"description": "TonB, proline-rich region", "go_ids": [], "go_terms": [], "name": "TonB_pro-rich", "pathway_ids": ["R-HSA-9638334", "R-HSA-9927020", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9927020:r:Heme assimilation", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Domain"}, "IPR049925": {"description": "Plasmid stabilization protein StbA-like", "go_ids": [], "go_terms": [], "name": "StbA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049926": {"description": "Plasmid transfer protein HtdO-like", "go_ids": [], "go_terms": [], "name": "HtdO-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049928": {"description": "Type III secretion system effector XopP-like, beta/gammaproteobacteria", "go_ids": [], "go_terms": [], "name": "XopP-like_beta/gammaproteobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049929": {"description": "Type III toxin-antitoxin system, toxin TenpN-like", "go_ids": [], "go_terms": [], "name": "TenpN-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049932": {"description": "Nuclear envelope-associated protein 1-4", "go_ids": [], "go_terms": [], "name": "NEAP1-4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049933": {"description": "RpoE leader peptide", "go_ids": [], "go_terms": [], "name": "RseD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049934": {"description": "Outer membrane protein GjpA-like", "go_ids": [], "go_terms": [], "name": "GjpA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049938": {"description": "Chp1, SPOC domain", "go_ids": [], "go_terms": [], "name": "SPOC_Chp1p", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049939": {"description": "Nitrogenase MoFe cofactor biosynthesis protein NifE-like", "go_ids": [], "go_terms": [], "name": "NifE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049940": {"description": "Glutamyl-Q tRNA(Asp) synthetase/Glutamate--tRNA ligase", "go_ids": [], "go_terms": [], "name": "GluQ/Sye", "pathway_ids": ["PWY-5188", "R-HSA-379726"], "pathways": ["PWY-5188:t:tetrapyrrole biosynthesis I (from glutamate)", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation"], "type": "Family"}, "IPR049941": {"description": "Lysophospholipid acyltransferase 7/Porcupine-like", "go_ids": [], "go_terms": [], "name": "LPLAT_7/PORCN-like", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-GGA-1482839", "R-GGA-1482788", "R-HSA-5340573", "R-DME-1482839", "R-SPO-1482839", "R-DME-1482788", "R-MMU-422085", "R-RNO-1482788", "R-HSA-1482922", "R-SCE-1482839", "R-MMU-1482788", "R-RNO-422085", "R-SCE-1482922", "R-RNO-1482801", "R-RNO-1482839", "R-CEL-1482801", "R-CEL-1482839", "R-HSA-3238698", "R-DRE-1482922", "R-MMU-1482839", "R-HSA-422085", "R-DME-1482801", "R-HSA-1482801", "R-DME-1482922", "R-SCE-1482801", "R-SPO-1482922", "R-MMU-1482922", "R-SPO-1482788", "R-HSA-1482839", "R-DRE-422085", "R-BTA-1482922", "R-CEL-1482922", "R-CEL-1482788", "R-SPO-1482801", "R-MMU-1482801", "R-SCE-1482788", "R-HSA-1482788"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-GGA-1482839:r:Acyl chain remodelling of PE", "R-GGA-1482788:r:Acyl chain remodelling of PC", "R-HSA-5340573:r:LGK974 inhibits PORCN", "R-DME-1482839:r:Acyl chain remodelling of PE", "R-SPO-1482839:r:Acyl chain remodelling of PE", "R-DME-1482788:r:Acyl chain remodelling of PC", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-SCE-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-SCE-1482922:r:Acyl chain remodelling of PI", "R-RNO-1482801:r:Acyl chain remodelling of PS", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-CEL-1482801:r:Acyl chain remodelling of PS", "R-CEL-1482839:r:Acyl chain remodelling of PE", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking", "R-DRE-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-DME-1482801:r:Acyl chain remodelling of PS", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-DME-1482922:r:Acyl chain remodelling of PI", "R-SCE-1482801:r:Acyl chain remodelling of PS", "R-SPO-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-SPO-1482788:r:Acyl chain remodelling of PC", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-DRE-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-1482922:r:Acyl chain remodelling of PI", "R-CEL-1482922:r:Acyl chain remodelling of PI", "R-CEL-1482788:r:Acyl chain remodelling of PC", "R-SPO-1482801:r:Acyl chain remodelling of PS", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-SCE-1482788:r:Acyl chain remodelling of PC", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Family"}, "IPR049942": {"description": "DML1/Misato", "go_ids": ["GO:0007005"], "go_terms": ["GO:0007005:mitochondrion organization:P"], "name": "DML1/Misato", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049943": {"description": "Serine hydroxymethyltransferase-like", "go_ids": [], "go_terms": [], "name": "Ser_HO-MeTrfase-like", "pathway_ids": ["PWY-3661", "PWY-8363", "PWY-2201", "PWY-181", "PWY-1622", "PWY-8325", "PWY-2161", "PWY-5497", "PWY-8362", "PWY-3841", "R-MMU-9837999", "R-SCE-71262", "R-MMU-9013408", "R-HSA-196757", "R-BTA-9013408", "R-MMU-71262", "R-MMU-196757", "R-SPO-9837999", "R-SPO-71262", "R-BTA-9837999", "R-SCE-9837999", "R-BTA-196757", "R-CEL-71262", "R-HSA-9837999", "R-HSA-9013408", "R-SCE-196757", "R-SPO-196757", "R-HSA-71262", "R-CEL-196757"], "pathways": ["PWY-3661:t:glycine betaine degradation I", "PWY-8363:t:photorespiration III", "PWY-2201:t:folate transformations I", "PWY-181:t:photorespiration I", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-8325:t:glycine betaine degradation III", "PWY-2161:t:folate polyglutamylation", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8362:t:photorespiration II", "PWY-3841:t:folate transformations II (plants)", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SCE-71262:r:Carnitine synthesis", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-196757:r:Metabolism of folate and pterines", "R-BTA-9013408:r:RHOG GTPase cycle", "R-MMU-71262:r:Carnitine synthesis", "R-MMU-196757:r:Metabolism of folate and pterines", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SPO-71262:r:Carnitine synthesis", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-BTA-196757:r:Metabolism of folate and pterines", "R-CEL-71262:r:Carnitine synthesis", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-SCE-196757:r:Metabolism of folate and pterines", "R-SPO-196757:r:Metabolism of folate and pterines", "R-HSA-71262:r:Carnitine synthesis", "R-CEL-196757:r:Metabolism of folate and pterines"], "type": "Family"}, "IPR049945": {"description": "ORC1/DEAH AAA+ ATPase domain", "go_ids": ["GO:0016887"], "go_terms": ["GO:0016887:ATP hydrolysis activity:F"], "name": "AAA_22", "pathway_ids": ["R-DDI-68689", "R-SCE-68616", "R-DDI-68962", "R-SCE-68689", "R-MMU-68962", "R-DDI-68949", "R-MMU-176187", "R-MMU-69017", "R-MMU-68689", "R-MMU-68949", "R-SCE-69017", "R-SCE-176187", "R-SCE-68962", "R-DDI-68616"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68949:r:Orc1 removal from chromatin", "R-SCE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication"], "type": "Domain"}, "IPR049950": {"description": "Nickel storage protein Hpn", "go_ids": [], "go_terms": [], "name": "Hpn-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049951": {"description": "8-methylmenaquinol:fumarate reductase membrane anchor subunit", "go_ids": [], "go_terms": [], "name": "SdhE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049952": {"description": "Phospholipase D-like domain-containing anti-phage protein", "go_ids": [], "go_terms": [], "name": "PhospholipD-like_anti-phage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049953": {"description": "Anti-phage-associated", "go_ids": [], "go_terms": [], "name": "Antiphage_assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049954": {"description": "Anti-phage ATPase IteA-like", "go_ids": [], "go_terms": [], "name": "IteA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049955": {"description": "Anti-phage peptidase IteS-like", "go_ids": [], "go_terms": [], "name": "IteS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049956": {"description": "Acetoacetyl-CoA reductase PhaB, cyanobacteria", "go_ids": ["GO:0016614"], "go_terms": ["GO:0016614:oxidoreductase activity, acting on CH-OH group of donors:F"], "name": "PhaB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049957": {"description": "Acetoacetyl-CoA reductase PhaA, cyanobacteria", "go_ids": [], "go_terms": [], "name": "PhaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049959": {"description": "MAP_0585-like", "go_ids": [], "go_terms": [], "name": "MAP_0585-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049960": {"description": "SpoV, N-terminal", "go_ids": [], "go_terms": [], "name": "SpoV_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049961": {"description": "ThiI, N-terminal", "go_ids": [], "go_terms": [], "name": "ThiI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR049963": {"description": "Anti-phage protein Ppl", "go_ids": [], "go_terms": [], "name": "Ppl_antiphage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049964": {"description": "Sialidase A repeat", "go_ids": [], "go_terms": [], "name": "NanA_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR049965": {"description": "Anti-phage protein Upx-like", "go_ids": [], "go_terms": [], "name": "Upx-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049966": {"description": "Dot/Icm T4SS effector LegC2/C7", "go_ids": [], "go_terms": [], "name": "T4SS_LegC2C7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049967": {"description": "Membrane protein NGO_0222-like", "go_ids": [], "go_terms": [], "name": "NGO_0222-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049968": {"description": "Dot/Icm T4SS effector AnkD/LegA15", "go_ids": [], "go_terms": [], "name": "T4SS_AnkD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049969": {"description": "Dot/Icm T4SS effector AnkH/LegA3", "go_ids": [], "go_terms": [], "name": "T4SS_AnkH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049970": {"description": "Amuc_1102-like", "go_ids": [], "go_terms": [], "name": "Amuc_1102-like", "pathway_ids": [], "pathways": [], "type": 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"go_ids": [], "go_terms": [], "name": "Capsid_mycobact-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049996": {"description": "Plasmid replication protein Slr7037-like", "go_ids": [], "go_terms": [], "name": "Slr7037-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049997": {"description": "Type IV pilus outer membrane protein Amuc_1098-like", "go_ids": [], "go_terms": [], "name": "Amuc_1098-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049998": {"description": "Acetophenone carboxylase epsilon subunit", "go_ids": [], "go_terms": [], "name": "ApcE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR049999": {"description": "Acetophenone carboxylase delta subunit", "go_ids": [], "go_terms": [], "name": "ApcD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050000": {"description": "Acetophenone carboxylase gamma subunit", "go_ids": [], "go_terms": [], "name": "ApcC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050001": {"description": "Acetophenone carboxylase beta subunit", "go_ids": [], "go_terms": [], "name": "ApcB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050002": {"description": "Mycofactocin biosynthesis chaperone MftB-like", "go_ids": [], "go_terms": [], "name": "MftB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050003": {"description": "HgcAB-like fusion protein", "go_ids": [], "go_terms": [], "name": "HgcAB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050004": {"description": "DNA-binding protein HMf-2-like", "go_ids": [], "go_terms": [], "name": "HmfB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050005": {"description": "D-erythronate dehydrogenase", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "DenD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050006": {"description": "L-threonate dehydrogenase", "go_ids": ["GO:0016616"], "go_terms": ["GO:0016616:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:F"], "name": "LtnD", "pathway_ids": ["PWY-7874"], "pathways": ["PWY-7874:t:L-threonate degradation"], "type": "Family"}, "IPR050007": {"description": "3-oxo-tetronate kinase", "go_ids": [], "go_terms": [], "name": "OtnK", "pathway_ids": ["PWY-7873", "PWY-7874"], "pathways": ["PWY-7873:t:D-erythronate degradation II", "PWY-7874:t:L-threonate degradation"], "type": "Family"}, "IPR050008": {"description": "MFS transporter MMSYN1_0478-like", "go_ids": [], "go_terms": [], "name": "MMSYN1_0478-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050009": {"description": "3-dehydroshikimate dehydratase QuiC", "go_ids": [], "go_terms": [], "name": "QuiC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050010": {"description": "ETEC_3214-like domain", "go_ids": [], "go_terms": [], "name": "ETEC_3214_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR050011": {"description": "2-oxoglutarate ferredoxin oxidoreductase subunit delta", "go_ids": [], "go_terms": [], "name": "OGOR_delta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050012": {"description": "Trans-4-hydroxy-L-proline dehydratase", "go_ids": ["GO:0016835"], "go_terms": ["GO:0016835:carbon-oxygen lyase activity:F"], "name": "Glycl_HYPD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050013": {"description": "3-oxo-tetronate 4-phosphate decarboxylase", "go_ids": ["GO:0019323", "GO:0016832"], "go_terms": ["GO:0019323:pentose catabolic process:P", "GO:0016832:aldehyde-lyase activity:F"], "name": "OtnC", "pathway_ids": ["PWY-7872", "PWY-7873", "PWY-7871", "PWY-7874"], "pathways": ["PWY-7872:t:D-erythronate degradation I", "PWY-7873:t:D-erythronate degradation II", "PWY-7871:t:D-threonate degradation", "PWY-7874:t:L-threonate degradation"], "type": "Family"}, "IPR050014": {"description": "Trans-4-hydroxy-L-proline dehydratase activase", "go_ids": ["GO:0043364"], "go_terms": ["GO:0043364:glycyl-radical enzyme activating activity:F"], "name": "T4HPD_activ_SAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050015": {"description": "3-oxo-isoapionate kinase OiaK", "go_ids": [], "go_terms": [], "name": "OiaK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050016": {"description": "Dot/Icm T4SS effector AnkX/LegA8", "go_ids": ["GO:0044605"], "go_terms": ["GO:0044605:phosphocholine transferase activity:F"], "name": "T4SS_AnkX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050017": {"description": "Dipeptide ABC transporter periplasmic-binding protein DppA", "go_ids": ["GO:0042938", "GO:0071916", "GO:0030288"], "go_terms": ["GO:0042938:dipeptide transport:P", "GO:0071916:dipeptide transmembrane transporter activity:F", "GO:0030288:outer membrane-bounded periplasmic space:C"], "name": "DppA_dipep", "pathway_ids": ["R-HSA-9927020"], "pathways": ["R-HSA-9927020:r:Heme assimilation"], "type": "Family"}, "IPR050018": {"description": "Dot/Icm T4SS effector AnkY/LegA9", "go_ids": [], "go_terms": [], "name": "T4SS_AnkY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050019": {"description": "Dot/Icm T4SS effector AnkQ/LegA10", "go_ids": [], "go_terms": [], "name": "T4SS_AnkQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050020": {"description": "Dimethylsulfoniopropionate lyase DddP", "go_ids": [], "go_terms": [], "name": "DddP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050021": {"description": "Dipeptide ABC transporter ATP-binding subunit DppF", "go_ids": ["GO:0005524", "GO:0042938", "GO:0071916"], "go_terms": ["GO:0005524:ATP binding:F", "GO:0042938:dipeptide transport:P", "GO:0071916:dipeptide transmembrane transporter activity:F"], "name": "DppF", "pathway_ids": ["R-HSA-9927020"], "pathways": ["R-HSA-9927020:r:Heme assimilation"], "type": "Family"}, "IPR050022": {"description": "Spermidine/putrescine ABC transporter 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"name": "Nit1_Morganellaceae", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050028": {"description": "Xanthine dehydrogenase subunit XdhA", "go_ids": ["GO:0004854", "GO:0002197"], "go_terms": ["GO:0004854:xanthine dehydrogenase activity:F", "GO:0002197:xanthine dehydrogenase complex:C"], "name": "XdhA_XDHase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050029": {"description": "Acetylxylan esterase", "go_ids": ["GO:0046555"], "go_terms": ["GO:0046555:acetylxylan esterase activity:F"], "name": "AxeA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050030": {"description": "3-oxo-isoapionate-4-phosphate decarboxylase", "go_ids": [], "go_terms": [], "name": "OiaX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050031": {"description": "Xanthine dehydrogenase subunit XdhB", "go_ids": ["GO:0004854", "GO:0002197"], "go_terms": ["GO:0004854:xanthine dehydrogenase activity:F", "GO:0002197:xanthine dehydrogenase complex:C"], "name": "XdhB_XDHase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050032": {"description": "3-sulfinopropanoyl-CoA desulfinase", "go_ids": [], "go_terms": [], "name": "AcdA", "pathway_ids": ["PWY-7465", "PWY-7462"], "pathways": ["PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-7462:t:3,3'-disulfanediyldipropannoate degradation"], "type": "Family"}, "IPR050033": {"description": "Xanthine dehydrogenase subunit XdhC", "go_ids": ["GO:0004854", "GO:0006144"], "go_terms": ["GO:0004854:xanthine dehydrogenase activity:F", "GO:0006144:purine nucleobase metabolic process:P"], "name": "XdhC_XDHase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050034": {"description": "Oligopeptide ABC transporter substrate-binding protein Opp4A", "go_ids": [], "go_terms": [], "name": "Opp4A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050035": {"description": "Nickel ABC transporter substrate-binding protein NikA", "go_ids": [], "go_terms": [], "name": "NikA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050036": {"description": "Metal-staphylopine import system permease protein CntB", "go_ids": [], "go_terms": [], "name": "CntB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050037": {"description": "Putative alpha/beta hydrolase CPn0927-like", "go_ids": [], "go_terms": [], "name": "CPn0927-like928-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050038": {"description": "ADP-polyphosphate phosphotransferase", "go_ids": [], "go_terms": [], "name": "PPK2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050039": {"description": "Putative transporter MAB_1171c-like", "go_ids": [], "go_terms": [], "name": "MAB_1171c-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050040": {"description": "Acetylxylan esterase/glucomannan deacetylase", "go_ids": ["GO:0045493", "GO:2000884"], "go_terms": ["GO:0045493:xylan catabolic process:P", "GO:2000884:glucomannan catabolic process:P"], "name": "CE2A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050041": {"description": "Acryloyl-CoA reductase electron transfer subunit beta", "go_ids": [], "go_terms": [], "name": "ETF_beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050042": {"description": "Acryloyl-CoA reductase", "go_ids": ["GO:0043958"], "go_terms": ["GO:0043958:acryloyl-CoA reductase (NADH) activity:F"], "name": "AcrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050043": {"description": "IncP plasmid survival protein KfrC-like domain", "go_ids": [], "go_terms": [], "name": "KfrC-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR050044": {"description": "Acryloyl-CoA reductase electron transfer subunit gamma", "go_ids": [], "go_terms": [], "name": "AcrB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050045": {"description": "Nickel import system permease protein NikB", "go_ids": ["GO:0015099", "GO:0015675"], "go_terms": ["GO:0015099:nickel cation transmembrane transporter activity:F", "GO:0015675:nickel cation transport:P"], "name": "Opp2B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050046": {"description": "MFS cation transporter, mollicutes", "go_ids": [], "go_terms": [], "name": "MSF_cation_mollicutes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050047": {"description": "Disulfide reductase DsbH", "go_ids": [], "go_terms": [], "name": "DsbH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050048": {"description": "Trans-2-enoyl-CoA reductase-like, NAD(P)H binding domain", "go_ids": [], "go_terms": [], "name": "FabV-like_NADH_b", "pathway_ids": ["PWY-7664", "PWY-8175", "PWY-7858", "PWY-8174", "PWY-8203", "PWY-7663", "PWYG-321", "PWY-5971", "PWY-5973", "PWY-5989", "PWY-6519", "PWY-6282", "PWY-8173"], "pathways": ["PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWYG-321:t:mycolate biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis"], "type": "Domain"}, "IPR050049": {"description": "Dodecin, bacteria", "go_ids": [], "go_terms": [], "name": "Dodecin_bact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050050": {"description": "Carboxynorspermidine synthase", "go_ids": [], "go_terms": [], "name": "CANSDH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050051": {"description": "Type VII secretion system protein EccE domain", "go_ids": [], "go_terms": [], "name": "EccE_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR050052": {"description": "ATP-dependent Clp protease ATP-binding subunit ClpX", "go_ids": [], "go_terms": [], "name": "ATP-dep_Clp_protease_ClpX", "pathway_ids": ["R-HSA-9837999", "R-MMU-9837999", "R-RNO-9837999"], "pathways": ["R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-9837999:r:Mitochondrial protein degradation"], "type": "Family"}, "IPR050053": {"description": "ATPase alpha/beta chains", "go_ids": [], "go_terms": [], "name": "ATPase_alpha/beta_chains", "pathway_ids": ["PWY-7980", "R-DDI-9837999", "R-MMU-9837999", "R-HSA-2151201", "R-DDI-1268020", "R-CEL-9837999", "R-CFA-9837999", "R-CFA-1268020", "R-DME-9837999", "R-CEL-163210", "R-MMU-163210", "R-DME-163210", "R-CEL-8949613", "R-RNO-9837999", "R-CFA-163210", "R-CFA-8949613", "R-HSA-8949613", "R-HSA-163210", "R-DME-8949613", "R-HSA-1268020", "R-SPO-9837999", "R-MMU-1268020", "R-SCE-9837999", "R-HSA-9837999", "R-RNO-163210", "R-CEL-1268020", "R-RNO-8949613", "R-DME-1268020", "R-MMU-8949613", "R-RNO-1268020"], "pathways": ["PWY-7980:t:ATP biosynthesis", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DDI-1268020:r:Mitochondrial protein import", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-CFA-9837999:r:Mitochondrial protein degradation", "R-CFA-1268020:r:Mitochondrial protein import", "R-DME-9837999:r:Mitochondrial protein degradation", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-CFA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CFA-8949613:r:Cristae formation", 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"go_terms": [], "name": "GlmU-like", "pathway_ids": ["PWY-5514"], "pathways": ["PWY-5514:t:UDP-N-acetyl-D-galactosamine biosynthesis II"], "type": "Family"}, "IPR050066": {"description": "UvrABC system protein C", "go_ids": [], "go_terms": [], "name": "UvrABC_protein_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050067": {"description": "Isopropylmalate dehydratase and related enzymes", "go_ids": [], "go_terms": [], "name": "IPM_dehydratase_rel_enz", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050069": {"description": "Urease subunit", "go_ids": [], "go_terms": [], "name": "Urease_subunit", "pathway_ids": ["PWY-5704"], "pathways": ["PWY-5704:t:urea degradation II"], "type": "Family"}, "IPR050071": {"description": "Dehydroquinate Synthase", "go_ids": [], "go_terms": [], "name": "Dehydroquinate_synthase", "pathway_ids": ["PWY-6164", "R-MTU-964903"], "pathways": ["PWY-6164:t:3-dehydroquinate biosynthesis I", "R-MTU-964903:r:Chorismate via Shikimate Pathway"], "type": "Family"}, "IPR050072": {"description": "Peptidase M20A, bacterial cell wall biosynthesis", "go_ids": [], "go_terms": [], "name": "Peptidase_M20A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050073": {"description": "2-IPM synthase/homocitrate synthase-like", "go_ids": [], "go_terms": [], "name": "2-IPM_HCS-like", "pathway_ids": ["PWY-6871"], "pathways": ["PWY-6871:t:3-methylbutanol biosynthesis (engineered)"], "type": "Family"}, "IPR050074": {"description": "Dihydroorotate dehydrogenase", "go_ids": [], "go_terms": [], "name": "DHO_dehydrogenase", "pathway_ids": ["PWY-5686", "R-MMU-500753", "R-PFA-500753", "R-DME-500753", "R-RNO-500753", "R-HSA-500753", "R-SPO-500753"], "pathways": ["PWY-5686:t:UMP biosynthesis I", "R-MMU-500753:r:Pyrimidine biosynthesis", "R-PFA-500753:r:Pyrimidine biosynthesis", "R-DME-500753:r:Pyrimidine biosynthesis", "R-RNO-500753:r:Pyrimidine biosynthesis", "R-HSA-500753:r:Pyrimidine biosynthesis", "R-SPO-500753:r:Pyrimidine biosynthesis"], "type": "Family"}, "IPR050075": {"description": "3-isopropylmalate dehydratase small subunit", "go_ids": [], "go_terms": [], "name": "LeuD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050077": {"description": "LexA repressor", "go_ids": [], "go_terms": [], "name": "LexA_repressor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050078": {"description": "Ribosomal protein L11 methyltransferase PrmA", "go_ids": [], "go_terms": [], "name": "Ribosomal_L11_MeTrfase_PrmA", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-8876725", "R-CEL-8876725", "R-DRE-8876725", "R-MMU-8876725", "R-RNO-8876725"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline 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glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-8876725:r:Protein methylation", "R-CEL-8876725:r:Protein methylation", "R-DRE-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation", "R-RNO-8876725:r:Protein methylation"], "type": "Family"}, "IPR050080": {"description": "Ribonuclease PH", "go_ids": [], "go_terms": [], "name": "RNase_PH", "pathway_ids": ["R-BTA-450604", "R-MMU-450385", "R-DRE-450385", "R-HSA-9930044", "R-XTR-6791226", "R-XTR-450385", "R-CEL-450385", "R-BTA-450385", "R-MMU-429958", "R-XTR-450513", "R-SPO-9930044", "R-SCE-450385", "R-DRE-9930044", "R-SCE-429958", "R-HSA-380994", "R-SCE-6791226", "R-CEL-429958", "R-CEL-6791226", "R-HSA-429958", "R-SPO-429958", "R-MMU-9930044", "R-MMU-6791226", "R-BTA-429958", "R-DRE-450513", "R-XTR-429958", "R-BTA-6791226", "R-DRE-450604", "R-BTA-450513", "R-SCE-450513", "R-DRE-429958", "R-XTR-450604", "R-CEL-450513", "R-BTA-9930044", "R-HSA-450385", "R-XTR-9930044", "R-MMU-450513", "R-HSA-6791226", "R-MMU-450604", "R-HSA-450513", "R-HSA-450604", "R-CEL-9930044", "R-SPO-6791226"], "pathways": ["R-BTA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-MMU-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-HSA-9930044:r:Nuclear RNA decay", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-CEL-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-BTA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-XTR-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SPO-9930044:r:Nuclear RNA decay", "R-SCE-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-DRE-9930044:r:Nuclear RNA decay", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-380994:r:ATF4 activates genes in response to endoplasmic reticulum stress", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-XTR-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-SCE-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-XTR-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-9930044:r:Nuclear RNA decay", "R-HSA-450385:r:Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "R-XTR-9930044:r:Nuclear RNA decay", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-CEL-9930044:r:Nuclear RNA decay", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR050081": {"description": "Isoleucine--tRNA ligase", "go_ids": [], "go_terms": [], "name": "Ile-tRNA_ligase", "pathway_ids": ["R-DDI-9837999", "R-HSA-379726", "R-HSA-9837999", "R-MMU-9837999", "R-SPO-9837999", "R-SCE-9837999", "R-GGA-9837999"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-379726:r:Mitochondrial tRNA aminoacylation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-GGA-9837999:r:Mitochondrial protein degradation"], "type": "Family"}, "IPR050083": {"description": "Membrane-localized HtpX protease", "go_ids": [], "go_terms": [], "name": "HtpX_protease", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR050084": {"description": "NADPH-dependent 7-cyano-7-deazaguanine reductase", "go_ids": [], "go_terms": [], "name": "NADPH_dep_7-cyano-7-deazaG_red", "pathway_ids": ["PWY-6700"], "pathways": ["PWY-6700:t:queuosine biosynthesis I (de novo)"], "type": "Family"}, "IPR050085": {"description": "N-acetyl-gamma-glutamyl-phosphate reductase", "go_ids": [], "go_terms": [], "name": "AGPR", "pathway_ids": ["PWY-5154"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Family"}, "IPR050086": {"description": "Methionine import ATP-binding protein MetN-like", "go_ids": [], "go_terms": [], "name": "MetN_ABC_transporter-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050087": {"description": "8-amino-7-oxononanoate synthase class-II", "go_ids": [], "go_terms": [], "name": "AON_synthase_class-II", "pathway_ids": ["PWY-6578", "PWY-6519", "PWY-8203", "PWY-7147", "R-HSA-1989781", "R-RNO-189451", "R-MMU-9837999", "R-HSA-2151201", "R-DRE-189451", "R-MMU-189451", "R-HSA-189451", "R-BTA-1660661", "R-RNO-1660661", "R-GGA-421984", "R-RNO-9837999", "R-HSA-9837999", "R-HSA-1660661", "R-BTA-189451", "R-SCE-189451", "R-SPO-189451", "R-MMU-1660661"], "pathways": ["PWY-6578:t:8-amino-7-oxononanoate biosynthesis III", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7147:t:8-amino-7-oxononanoate biosynthesis II", "R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-189451:r:Heme biosynthesis", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DRE-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-GGA-421984:r:Heme synthesis", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-BTA-189451:r:Heme biosynthesis", "R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR050088": {"description": "IspD/TarI cytidylyltransferase, bacterial-type", "go_ids": [], "go_terms": [], "name": "IspD/TarI_cytidylyltransf_bact", "pathway_ids": ["PWY-7560"], "pathways": ["PWY-7560:t:methylerythritol phosphate pathway II"], "type": "Family"}, "IPR050090": {"description": "Tyrosine recombinase XerC/XerD-like", "go_ids": [], "go_terms": [], "name": "XerCD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050091": {"description": "Polyketide and Nonribosomal Peptide Biosynthesis Enzymes", "go_ids": [], "go_terms": [], "name": "PKS_NRPS_Biosynth_Enz", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-163765", "R-HSA-9029558", "R-HSA-75105", "R-HSA-9918487", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-MMU-199220", "R-MMU-75105", "R-HSA-9918481", "R-RNO-199220", "R-HSA-2426168"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide 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biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline 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"PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", 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["R-DME-947581:r:Molybdenum cofactor biosynthesis", "R-BTA-947581:r:Molybdenum cofactor biosynthesis", "R-DDI-947581:r:Molybdenum cofactor biosynthesis", "R-HSA-947581:r:Molybdenum cofactor biosynthesis", "R-MMU-947581:r:Molybdenum cofactor biosynthesis"], "type": "Family"}, "IPR050106": {"description": "Histidinol-phosphate aminotransferase", "go_ids": [], "go_terms": [], "name": "HistidinolP_aminotransfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050107": {"description": "ABC transporter carbohydrate import ATP-binding proteins", "go_ids": [], "go_terms": [], "name": "ABC_carbohydrate_import_ATPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050108": {"description": "Cyclin-dependent kinase", "go_ids": [], "go_terms": [], "name": "CDK", "pathway_ids": ["R-SPO-9018519", "R-BTA-2559585", "R-MMU-2173796", "R-RNO-5696395", "R-MMU-3301854", "R-BTA-6804116", "R-RNO-2980767", "R-HSA-8934593", "R-DME-1538133", "R-DME-6804756", "R-MMU-171319", "R-CEL-674695", "R-RNO-6804757", "R-HSA-6804756", "R-BTA-2559586", "R-CEL-112382", "R-CEL-6782135", "R-HSA-6804114", "R-RNO-176408", "R-BTA-69017", "R-DME-2559586", "R-DDI-113418", "R-RNO-9841922", "R-MMU-72086", "R-HSA-68911", "R-DDI-68911", "R-SPO-73779", "R-SPO-73776", "R-RNO-380270", "R-DDI-187577", "R-DME-187577", "R-MMU-187577", "R-RNO-68875", "R-DDI-5696395", "R-DME-110056", "R-HSA-8862803", "R-HSA-2514853", "R-GGA-265976", "R-DME-2565942", "R-RNO-69478", "R-MMU-69200", "R-BTA-69563", "R-MMU-69202", "R-HSA-75035", "R-RNO-2565942", "R-DDI-73772", "R-DDI-6796648", "R-HSA-912446", "R-BTA-380320", "R-HSA-6782210", "R-CEL-399956", "R-DDI-76042", "R-MMU-68875", "R-DME-176187", "R-CEL-69273", "R-SCE-73779", "R-BTA-110056", "R-RNO-399956", "R-BTA-399956", "R-MMU-6796648", "R-BTA-187577", "R-DME-69563", "R-HSA-167243", "R-RNO-6796648", "R-DDI-69231", "R-RNO-75955", "R-HSA-381340", "R-SCE-6781823", "R-SPO-69017", "R-DDI-69200", "R-DME-6798695", "R-DME-174184", "R-BTA-674695", "R-HSA-110056", "R-SSC-187577", "R-MMU-176412", "R-MMU-3214858", "R-DME-9833482", "R-MMU-174184", "R-HSA-167290", "R-DME-3301854", "R-RNO-187577", "R-MMU-77075", "R-HSA-75955", "R-CEL-2565942", "R-SPO-6782210", "R-CEL-9018519", "R-SPO-68962", "R-HSA-674695", "R-HSA-76042", "R-SCE-73772", "R-RNO-69017", "R-RNO-9833482", "R-DME-69656", "R-HSA-6798695", "R-RNO-6807505", "R-RNO-2559582", "R-BTA-2980767", "R-HSA-167238", "R-HSA-5689896", "R-RNO-674695", "R-BTA-9841922", "R-CEL-6798695", "R-CEL-4419969", "R-HSA-69273", "R-BTA-6798695", "R-BTA-75035", "R-DME-68875", "R-HSA-6796648", "R-MMU-2565942", "R-DME-69478", "R-HSA-9841922", "R-HSA-6781823", "R-RNO-380320", "R-CEL-2980767", "R-HSA-167287", "R-HSA-167246", "R-MMU-5696395", "R-SPO-5696395", "R-HSA-5693607", "R-RNO-68911", "R-HSA-9630791", "R-HSA-6804757", "R-DME-9616222", "R-HSA-75953", "R-BTA-5620912", "R-BTA-5693607", "R-HSA-77075", "R-HSA-2299718", "R-SPO-72086", "R-HSA-212436", "R-DRE-9018519", "R-RNO-6782210", "R-CEL-69200", "R-SSC-3214858", "R-SPO-113418", "R-BTA-3301854", "R-SPO-2559582", "R-HSA-9632697", "R-DDI-73779", "R-BTA-2559580", "R-BTA-2559582", "R-MMU-2559586", "R-BTA-5687128", "R-DDI-69656", "R-CEL-2173796", "R-DDI-3214858", "R-DDI-6781823", "R-RNO-5693607", "R-XTR-112382", "R-RNO-73762", "R-MMU-2559580", "R-RNO-8939236", "R-MMU-6807505", "R-SCE-76042", "R-CEL-6781823", "R-HSA-162658", "R-SPO-69202", "R-RNO-174184", "R-BTA-171319", "R-CEL-69017", "R-HSA-4419969", "R-HSA-167200", "R-RNO-112382", "R-SSC-9754119", "R-MMU-176187", "R-BTA-176408", "R-MMU-8854518", "R-MMU-6798695", "R-CEL-9754119", "R-MMU-9616222", "R-HSA-9632700", "R-DME-68911", "R-SSC-8878166", "R-RNO-75953", "R-SCE-6782135", "R-RNO-2559585", "R-DDI-176408", "R-DDI-6782135", "R-SPO-6798695", "R-HSA-399956", "R-RNO-176417", "R-DDI-9754119", "R-DME-6804114", "R-CEL-69202", "R-RNO-2500257", "R-XTR-9018519", "R-MMU-8849470", "R-RNO-171319", "R-BTA-2173796", "R-DDI-75815", "R-BTA-68962", "R-HSA-171319", "R-HSA-2565942", "R-BTA-9754119", "R-MMU-180024", "R-RNO-110056", "R-HSA-113418", "R-RNO-69656", "R-BTA-112382", "R-RNO-8852276", "R-BTA-69656", "R-MMU-110056", "R-XTR-2173796", "R-CEL-68911", "R-MMU-2995383", "R-HSA-180024", "R-DDI-69017", "R-CEL-8934593", "R-MMU-2500257", "R-RNO-69202", "R-RNO-72086", "R-CEL-6804114", "R-HSA-2500257", "R-SSC-2559582", "R-RNO-9929491", "R-RNO-8854518", "R-SCE-72086", "R-HSA-2894862", "R-RNO-75035", "R-HSA-73762", "R-CEL-77075", "R-SCE-68962", "R-BTA-180024", "R-RNO-2559580", "R-SCE-77075", "R-HSA-69017", "R-CEL-3214858", "R-BTA-4419969", "R-SPO-6782135", "R-DME-176417", "R-HSA-380259", "R-HSA-69202", "R-XTR-6807505", "R-RNO-6781823", "R-DME-69273", "R-HSA-9754119", "R-CEL-8849470", "R-RNO-68949", "R-HSA-9833482", "R-HSA-113507", "R-RNO-73779", "R-RNO-3301854", "R-HSA-427413", "R-MMU-69017", "R-SSC-69231", "R-RNO-5687128", "R-BTA-6804114", "R-RNO-6804114", "R-BTA-2299718", "R-SPO-6781823", "R-MMU-5689896", "R-HSA-167158", "R-MMU-75955", "R-MMU-380320", "R-MMU-112382", "R-BTA-9018519", "R-BTA-176187", "R-BTA-69202", "R-SCE-6807505", "R-MMU-75815", "R-SPO-76042", "R-HSA-73776", "R-RNO-6804116", "R-BTA-75815", "R-BTA-2565942", "R-DDI-674695", "R-RNO-380284", "R-CEL-75953", "R-HSA-9616222", "R-MMU-5620912", "R-CEL-69231", "R-HSA-2122947", "R-RNO-69563", "R-HSA-9661069", "R-DME-2559582", "R-HSA-9929491", "R-RNO-176412", "R-DME-69202", "R-DME-174048", "R-XTR-674695", "R-SSC-9616222", "R-RNO-174048", "R-HSA-983231", "R-MMU-380270", "R-MMU-2559582", "R-DME-2500257", "R-CEL-6782210", "R-RNO-180024", "R-XTR-6796648", "R-HSA-167161", "R-MMU-69656", "R-DME-69200", "R-CEL-5696395", "R-HSA-5696395", "R-HSA-167160", "R-DDI-77075", "R-SSC-2559580", "R-HSA-174048", "R-MMU-73772", "R-HSA-9931529", "R-HSA-2644606", "R-MMU-5687128", "R-MMU-69273", "R-HSA-9031628", "R-DDI-69202", "R-BTA-9833482", "R-HSA-9768919", "R-SCE-73776", "R-BTA-69478", "R-DME-69017", "R-RNO-2173796", "R-HSA-68949", "R-SSC-75815", "R-RNO-9754119", "R-HSA-6781827", "R-DME-2995383", "R-MMU-2980767", "R-MMU-8852276", "R-BTA-68949", "R-BTA-176412", "R-RNO-8849470", "R-SCE-6798695", "R-BTA-176417", "R-MMU-68949", "R-MMU-8934593", "R-MMU-380284", "R-CEL-73772", "R-CEL-9616222", "R-MMU-8939236", "R-MMU-6781823", "R-CEL-69656", "R-HSA-8849470", "R-CEL-2559586", "R-SPO-69656", "R-CEL-75815", "R-HSA-68962", "R-HSA-1538133", "R-MMU-6804116", "R-MMU-73776", "R-BTA-174184", "R-SPO-9754119", "R-SCE-176187", "R-HSA-167172", "R-HSA-9032845", "R-HSA-176187", "R-BTA-1538133", "R-MMU-5693607", "R-HSA-176412", "R-MMU-176408", "R-RNO-113418", "R-CEL-75955", "R-MMU-176417", "R-SPO-69231", "R-MMU-6804757", "R-DME-176412", "R-RNO-75815", "R-HSA-2995383", "R-HSA-380270", "R-CEL-176408", "R-RNO-69273", "R-RNO-380259", "R-RNO-69231", "R-SPO-75815", "R-CEL-8878166", "R-SCE-9018519", "R-HSA-73863", "R-RNO-77075", "R-SPO-73772", "R-MMU-2299718", "R-BTA-69200", "R-CEL-69478", "R-DME-2173796", "R-SPO-68949", "R-DME-75035", "R-BTA-8878166", "R-BTA-6807505", "R-MMU-6804114", "R-HSA-8939236", "R-MMU-2559585", "R-HSA-112382", "R-HSA-73779", "R-HSA-6804116", "R-HSA-1989781", "R-BTA-69231", "R-DDI-1538133", "R-RNO-2995383", "R-SCE-75953", "R-MMU-113418", "R-CEL-3301854", "R-RNO-3214858", "R-DME-69231", "R-SPO-6807505", "R-HSA-380284", "R-RNO-176187", "R-CEL-187577", "R-RNO-73863", "R-BTA-68911", "R-HSA-8854518", "R-BTA-380259", "R-DRE-6807505", "R-HSA-380320", "R-MMU-9833482", "R-BTA-9929491", "R-DRE-6796648", "R-BTA-2995383", "R-BTA-8849470", "R-DDI-2559582", "R-CEL-110056", "R-MMU-9929491", "R-HSA-2980767", "R-HSA-8878166", "R-MMU-73779", "R-HSA-9825892", "R-CEL-69563", "R-HSA-176408", "R-HSA-9018519", "R-MMU-68911", "R-MMU-76042", "R-CEL-2500257", "R-DME-5693607", "R-SPO-75953", "R-RNO-1538133", "R-CEL-6807505", "R-RNO-76042", "R-MMU-68962", "R-CEL-9833482", "R-CEL-113418", "R-DDI-72086", "R-MMU-8878166", "R-MMU-674695", "R-DME-8878166", "R-MMU-69478", "R-MMU-9018519", "R-DDI-6807505", "R-CEL-9929491", "R-HSA-3301854", "R-HSA-2465910", "R-SCE-674695", "R-DDI-68949", "R-MMU-6782210", "R-RNO-4419969", "R-RNO-5689896", "R-CEL-6796648", "R-RNO-9616222", "R-HSA-2559586", "R-MMU-399956", "R-MMU-69231", "R-MMU-73762", "R-HSA-187577", "R-SPO-176408", "R-RNO-68962", "R-HSA-69205", "R-MMU-6782135", "R-HSA-2559585", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-HSA-2559582", "R-RNO-5620912", "R-HSA-68875", "R-HSA-174184", "R-HSA-3214858", "R-MMU-174048", "R-HSA-167162", "R-BTA-3214858", "R-SSC-2559585", "R-CEL-1538133", "R-HSA-167152", "R-RNO-6804756", "R-SPO-3214858", "R-HSA-9833110", "R-SCE-6782210", "R-HSA-5620912", "R-BTA-6796648", "R-BTA-380284", "R-HSA-2173796", "R-DME-68949", "R-DME-4419969", "R-SCE-6796648", "R-HSA-9630794", "R-RNO-69200", "R-RNO-2299718", "R-GGA-351451", "R-SPO-77075", "R-BTA-69273", "R-RNO-73772", "R-BTA-5689896", "R-RNO-2559586", "R-SCE-113418", "R-HSA-1362300", "R-BTA-174048", "R-HSA-8852276", "R-MMU-73863", "R-RNO-6782135", "R-HSA-6782135", "R-XTR-75955", "R-SSC-9929491", "R-MMU-69563", "R-CEL-68949", "R-HSA-5687128", "R-BTA-8854518", "R-BTA-380270", "R-DME-9841922", "R-DRE-674695", "R-HSA-176034", "R-MMU-4419969", "R-DDI-75953", "R-CEL-76042", "R-HSA-176417", "R-CEL-73779", "R-HSA-69563", "R-HSA-73772", "R-SPO-674695", "R-HSA-6807505", "R-MMU-75953", "R-HSA-2559580", "R-DME-176408", "R-MMU-9754119", "R-HSA-75815", "R-DDI-73776", "R-MMU-6804756", "R-DDI-6782210", "R-MMU-75035", "R-HSA-69231", "R-SSC-8849470", "R-RNO-9018519", "R-BTA-6804757", "R-RNO-73776", "R-DRE-75955", "R-MMU-1538133", "R-DME-68962", "R-HSA-69200", "R-HSA-69656", "R-DDI-68962", "R-BTA-6804756", "R-DDI-9929491", "R-HSA-9931530", "R-BTA-68875", "R-BTA-2500257", "R-DME-6804116", "R-SPO-6796648", "R-CEL-73776", "R-BTA-75955", "R-SPO-176187", "R-CEL-6804116", "R-MMU-380259", "R-HSA-69478"], "pathways": ["R-SPO-9018519:r:Estrogen-dependent gene expression", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-BTA-6804116:r:TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-RNO-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DME-1538133:r:G0 and Early G1", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-113418:r:Formation of the Early Elongation Complex", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-72086:r:mRNA Capping", "R-HSA-68911:r:G2 Phase", "R-DDI-68911:r:G2 Phase", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68875:r:Mitotic Prophase", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-110056:r:MAPK3 (ERK1) activation", "R-HSA-8862803:r:Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-2514853:r:Condensation of Prometaphase Chromosomes", "R-GGA-265976:r:Homologous DNA pairing and strand exchange", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-69478:r:G2/M DNA replication checkpoint", "R-MMU-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-BTA-69563:r:p53-Dependent G1 DNA Damage Response", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-73772:r:RNA Polymerase I Promoter Escape", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-912446:r:Meiotic recombination", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-68875:r:Mitotic Prophase", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-BTA-110056:r:MAPK3 (ERK1) activation", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-69563:r:p53-Dependent G1 DNA Damage Response", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DDI-69231:r:Cyclin D associated events in G1", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-69200:r:Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-DME-9833482:r:PKR-mediated signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", 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"R-BTA-1181150", "R-HSA-198765", "R-HSA-1181150", "R-MMU-198765", "R-CFA-418592", "R-CFA-168638", "R-BTA-437239", "R-BTA-9634635", "R-HSA-4086398", "R-RNO-5674499", "R-CEL-193648", "R-MMU-437239", "R-DDI-5687128", "R-RNO-9856649", "R-BTA-456926", "R-RNO-139910", "R-DME-9856649", "R-BTA-1295596", "R-BTA-198753", "R-DDI-198765", "R-CEL-2559580", "R-MMU-5654726", "R-CEL-5654733", "R-RNO-1181150", "R-HSA-877300", "R-MMU-450341", "R-DME-2173796", "R-MMU-525793", "R-CFA-6798695", "R-RNO-450341", "R-MMU-74749", "R-DME-5654733", "R-MMU-2559585", "R-CEL-3371453", "R-SPO-198765", "R-HSA-73728", "R-CEL-450321", "R-HSA-5674135", "R-RNO-5654726", "R-BTA-8939211", "R-SPO-418592", "R-DME-375165", "R-SCE-2559582", "R-HSA-432142", "R-RNO-74749", "R-CEL-198753", "R-GGA-437986", "R-MMU-1295596", "R-HSA-4420097", "R-MMU-2871796", "R-RNO-2173795", "R-SPO-881907", "R-GGA-5687128", "R-HSA-9649948", "R-DDI-2559582", "R-MMU-5668599", "R-HSA-9635465", "R-CEL-110056", "R-MMU-5654732", "R-BTA-877300", "R-CEL-9856649", "R-DME-112409", "R-DDI-432142", "R-DRE-6804756", "R-MMU-8939211", "R-DME-3371453", "R-DRE-9007892", "R-RNO-8853659", "R-BTA-3371453", "R-DRE-432142", "R-HSA-456926", "R-DME-9824585", "R-GGA-450321", "R-CEL-168638", "R-HSA-5654732", "R-MMU-982772", "R-MMU-8853659", "R-MMU-445144", "R-DME-202670", "R-HSA-2151209", "R-BTA-170968", "R-BTA-111995", "R-HSA-982772", "R-CEL-432142", "R-MMU-9634635", "R-DME-445144", "R-GGA-450341", "R-SPO-202670", "R-HSA-5654733", "R-RNO-4420097", "R-MMU-375165", "R-CEL-375165", "R-DME-418592", "R-RNO-3371453", "R-SCE-168638", "R-SPO-5687128", "R-DME-209425", "R-HSA-2559585", "R-CEL-437239", "R-HSA-2559582", "R-HSA-1169408", "R-DRE-450302", "R-MMU-69601", "R-DRE-9824585", "R-SPO-450341", "R-CFA-5668599", "R-HSA-6802946", "R-BTA-5654732", "R-BTA-2871796", "R-RNO-6804756", "R-CFA-525793", "R-DRE-168638", "R-HSA-2173796", "R-SPO-525793", "R-HSA-171007", "R-DME-450341", "R-HSA-9652169", "R-GGA-2871796", "R-RNO-112411", "R-HSA-193648", "R-RNO-9634635", "R-BTA-112409", "R-MMU-877300", "R-RNO-112409", "R-CEL-2029482", "R-MMU-418592", "R-SCE-198765", "R-CEL-69601", "R-SCE-525793", "R-HSA-5687128", "R-DDI-168638", "R-MMU-9634638", "R-DME-5654726", "R-RNO-198753", "R-DME-4420097", "R-SCE-198753", "R-DRE-525793", "R-HSA-5675221", "R-HSA-9842640", "R-RNO-418592", "R-HSA-879415", "R-CFA-450341", "R-HSA-2559580", "R-HSA-6802952", "R-MMU-6811558", "R-BTA-5673001", "R-HSA-2871796", "R-MMU-6804756", "R-CFA-69601", "R-SCE-450341", "R-HSA-9732724", "R-CEL-202670", "R-DME-2559585", "R-MMU-112409", "R-DME-209409", "R-MMU-9732724", "R-BTA-6811558", "R-HSA-450302", "R-CEL-4086398", "R-RNO-375165", "R-MMU-139910", "R-DDI-198753", "R-DME-209459", "R-HSA-6802955", "R-CFA-4086398", "R-RNO-193648"], "pathways": ["R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-DDI-6798695:r:Neutrophil degranulation", "R-DRE-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-202670:r:ERKs are inactivated", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-170968:r:Frs2-mediated activation", "R-DME-168638:r:NOD1/2 Signaling Pathway", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-HSA-437239:r:Recycling pathway of L1", "R-BTA-1502540:r:Signaling by Activin", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-202670:r:ERKs are inactivated", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-MMU-171007:r:p38MAPK events", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-DME-193648:r:NRAGE signals death through JNK", "R-HSA-450604:r:KSRP (KHSRP) binds and destabilizes mRNA", "R-SPO-432142:r:Platelet sensitization by LDL", "R-DME-5674499:r:Negative feedback regulation of MAPK pathway", "R-MMU-1181150:r:Signaling by NODAL", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-RNO-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-BTA-982772:r:Growth hormone receptor signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-SCE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-DME-110056:r:MAPK3 (ERK1) activation", "R-BTA-5674499:r:Negative feedback regulation of MAPK pathway", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-RNO-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-877300:r:Interferon gamma signaling", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-111446:r:Activation of BIM and translocation to mitochondria", "R-CEL-171007:r:p38MAPK events", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-MMU-202670:r:ERKs are inactivated", "R-MMU-1502540:r:Signaling by Activin", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-CEL-2871796:r:FCERI mediated MAPK activation", "R-CEL-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-74749:r:Signal attenuation", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DME-74749:r:Signal attenuation", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-CEL-9007892:r:Interleukin-38 signaling", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-1181150:r:Signaling by NODAL", "R-HSA-170968:r:Frs2-mediated activation", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9007892:r:Interleukin-38 signaling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-4086398:r:Ca2+ pathway", "R-DME-8939211:r:ESR-mediated signaling", "R-MMU-198753:r:ERK/MAPK targets", "R-RNO-111446:r:Activation of BIM and translocation to mitochondria", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-877300:r:Interferon gamma signaling", "R-MMU-111995:r:phospho-PLA2 pathway", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-202670:r:ERKs are inactivated", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-MMU-432142:r:Platelet sensitization by LDL", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-9627069:r:Regulation of the apoptosome activity", "R-CEL-450341:r:Activation of the AP-1 family of transcription factors", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-BTA-8853659:r:RET signaling", "R-HSA-8939211:r:ESR-mediated signaling", "R-BTA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-RNO-170968:r:Frs2-mediated activation", "R-RNO-73728:r:RNA Polymerase I Promoter Opening", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9007892:r:Interleukin-38 signaling", "R-BTA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DRE-198753:r:ERK/MAPK targets", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DRE-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-139910:r:Activation of BMF and translocation to mitochondria", "R-CEL-525793:r:Myogenesis", "R-DME-5674135:r:MAP2K and MAPK activation", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SCE-432142:r:Platelet sensitization by LDL", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-DME-437239:r:Recycling pathway of L1", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-1502540:r:Signaling by Activin", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-DME-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-162658:r:Golgi Cisternae Pericentriolar Stack Reorganization", "R-DME-171007:r:p38MAPK events", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-BTA-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-5674499:r:Negative feedback regulation of MAPK pathway", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-198765:r:Signalling to ERK5", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-BTA-5654726:r:Negative regulation of FGFR1 signaling", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-198753:r:ERK/MAPK targets", "R-DME-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-DRE-171007:r:p38MAPK events", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-CEL-1502540:r:Signaling by Activin", "R-BTA-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-525793:r:Myogenesis", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-450341:r:Activation of the AP-1 family of transcription factors", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-450341:r:Activation of the AP-1 family of transcription factors", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-DRE-5675221:r:Negative regulation of MAPK pathway", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DDI-418592:r:ADP signalling through P2Y purinoceptor 1", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-DDI-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-525793:r:Myogenesis", "R-MMU-5674499:r:Negative feedback regulation of MAPK pathway", "R-DME-170968:r:Frs2-mediated activation", "R-RNO-171007:r:p38MAPK events", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-CEL-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-CEL-445144:r:Signal transduction by L1", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-209397:r:Formation of the cytosolic BSK 'scaffolding complex'", "R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-BTA-74749:r:Signal attenuation", "R-DDI-202670:r:ERKs are inactivated", "R-SPO-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-4086398:r:Ca2+ pathway", "R-HSA-111995:r:phospho-PLA2 pathway", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9652817:r:Signaling by MAPK mutants", "R-RNO-9007892:r:Interleukin-38 signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-SCE-4086398:r:Ca2+ pathway", "R-DDI-525793:r:Myogenesis", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-444257:r:RSK activation", "R-SPO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-RNO-8939211:r:ESR-mediated signaling", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CEL-1181150:r:Signaling by NODAL", "R-DME-877300:r:Interferon gamma signaling", "R-CEL-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-RNO-111995:r:phospho-PLA2 pathway", "R-MMU-4086398:r:Ca2+ pathway", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-9634635:r:Estrogen-stimulated signaling through PRKCZ", "R-RNO-525793:r:Myogenesis", "R-SCE-881907:r:Gastrin-CREB signalling pathway via PKC and MAPK", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-BTA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-MMU-73728:r:RNA Polymerase I Promoter Opening", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-CEL-112409:r:RAF-independent MAPK1/3 activation", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-DRE-6798695:r:Neutrophil degranulation", 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"R-HSA-1839130", "R-DRE-5654221", "R-MMU-9034793", "R-RNO-5654719", "R-HSA-9669924", "R-HSA-388844", "R-HSA-9717329", "R-CFA-201556", "R-CEL-5654712", "R-CEL-5654221", "R-MMU-5654704", "R-MMU-190377", "R-HSA-1963642", "R-DME-8863795", "R-CEL-5654704", "R-GGA-1433557", "R-CFA-1433557", "R-HSA-2033519", "R-HSA-190372", "R-RNO-1251985", "R-DME-5654219", "R-HSA-9706369", "R-CEL-8856828", "R-MMU-74713", "R-HSA-8852405", "R-HSA-9665249", "R-HSA-5655332", "R-HSA-9603505", "R-HSA-5654726", "R-DME-2179392", "R-HSA-109704", "R-DME-5654719", "R-MMU-190322", "R-HSA-6785631", "R-MMU-1227986", "R-DRE-9851151", "R-HSA-190322", "R-MMU-1257604", "R-HSA-190371", "R-DME-177929", "R-HSA-1358803", "R-HSA-9634638", "R-HSA-74749", "R-HSA-9669934", "R-HSA-9842663", "R-HSA-180336", "R-HSA-8853336", "R-RNO-74713", "R-RNO-5654689", "R-MMU-190371", "R-HSA-9034013", "R-HSA-9009391", "R-DME-5654712", "R-MMU-1251985", "R-DRE-1257604", "R-CEL-179812", "R-HSA-187706", "R-HSA-8856825", "R-MMU-5654727", "R-RNO-9032759", 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"R-CEL-216083", "R-HSA-9717264", "R-HSA-2404192", "R-MMU-1433557", "R-HSA-9706374", "R-DME-5654704", "R-MMU-180292", "R-HSA-210993", "R-DME-9018519", "R-HSA-9034793", "R-CEL-180292", "R-DME-5140745", "R-HSA-9024909", "R-HSA-9673768", "R-HSA-194306", "R-CEL-1250196", "R-HSA-5673001", "R-HSA-6811558", "R-HSA-5218921", "R-CEL-212718", "R-HSA-9013695", "R-DRE-5654704", "R-DME-1250196", "R-CEL-186763", "R-HSA-1257604", "R-MMU-9034013", "R-DRE-190374", "R-DRE-5654700", "R-RNO-194306", "R-MMU-5654710", "R-HSA-1839128", "R-MMU-8863795", "R-HSA-9702605", "R-CEL-8849472", "R-HSA-167044", "R-MMU-2179392", "R-CEL-8863795", "R-DME-5654700", "R-HSA-74751", "R-DRE-9842663", "R-HSA-5654687", "R-DME-5654693", "R-RNO-109704", "R-HSA-1251932", "R-HSA-375165", "R-HSA-1250347", "R-CEL-1251985", "R-MMU-9842663", "R-HSA-9702614", "R-MMU-198203", "R-DRE-5654219", "R-CEL-5654706", "R-HSA-9673770", "R-MMU-8852405", "R-CEL-5140745", "R-CEL-8847993", "R-MMU-190373", "R-DME-190374", "R-DME-9009391", "R-CEL-5654699", "R-HSA-9938206", "R-DME-1250347", "R-RNO-1307965", "R-CEL-5654710", "R-DRE-449836", "R-MMU-5218921", "R-HSA-9025046", "R-GGA-1257604", "R-HSA-9674403", "R-DME-180292", "R-HSA-1839122", "R-MMU-9603381", "R-HSA-9645135", "R-HSA-216083", "R-HSA-9665246", "R-RNO-9034793", "R-HSA-5654706", "R-CEL-445144", "R-HSA-9927432", "R-RNO-186797", "R-HSA-1227986", "R-HSA-9665233", "R-DME-5654689", "R-CEL-8849468", "R-CEL-416572", "R-DRE-9856649", "R-HSA-186763", "R-HSA-177504", "R-HSA-5654227", "R-RNO-2428928", "R-HSA-9706377", "R-RNO-74751", "R-DRE-190375", "R-CEL-4420097", "R-HSA-5654710", "R-CEL-8849471", "R-RNO-1236394", "R-MMU-5654733", "R-DME-190373", "R-DRE-5654695", "R-DME-179812", "R-RNO-449836", "R-HSA-9702600", "R-MMU-177929", "R-RNO-1306955", "R-HSA-9607240", "R-CEL-8849470", "R-DRE-186797", "R-HSA-9026357", "R-HSA-3000178", "R-HSA-9665251", "R-RNO-2428933", "R-DME-9652282", "R-HSA-167021", "R-HSA-9918485", "R-RNO-9009391", "R-HSA-9702596", "R-MMU-9009391", "R-MMU-210993", "R-DME-5654732", "R-HSA-9669935", "R-RNO-8863795", "R-HSA-9674401", "R-CEL-5654695", "R-RNO-8847993", "R-CEL-1257604", "R-RNO-6811558", "R-HSA-8853659", "R-MMU-5654706", "R-HSA-9603381", "R-RNO-1963642", "R-HSA-9702632", "R-MMU-9652282", "R-CEL-190373", "R-DRE-6811558", "R-HSA-5140745", "R-DME-1251985", "R-MMU-5673001", "R-MMU-449836", "R-HSA-9669917", "R-HSA-9026527", "R-DME-190370", "R-MMU-77387", "R-HSA-182971", "R-HSA-5654727", "R-HSA-5654689", "R-RNO-445144", "R-HSA-1839120", "R-HSA-9674396", "R-DME-433692", "R-DME-212718", "R-MMU-190375", "R-HSA-9702590", "R-DME-1253288", "R-HSA-9609690", "R-CEL-5654727", "R-MMU-190372", "R-HSA-5637810", "R-HSA-8851708", "R-HSA-5654699", "R-HSA-1433559", "R-HSA-9703009", "R-RNO-5654688", "R-DME-5654695", "R-DME-1257604", "R-DRE-190371", "R-HSA-9793380", "R-HSA-445144", "R-MMU-9851151", "R-DME-182971", "R-MMU-186797", "R-CEL-8856825", "R-HSA-9768919", "R-HSA-8857538", "R-HSA-5655253", "R-HSA-5638303", "R-DME-1358803", "R-DME-5673001", "R-HSA-416572", "R-CFA-9851151", "R-MMU-5654699", "R-MMU-190374", "R-GGA-9856649", "R-HSA-9665737", "R-HSA-9665348", "R-HSA-2428933", "R-HSA-9717316", "R-RNO-1253288", "R-MMU-388844", "R-DRE-190377", "R-HSA-190374", "R-MMU-190370", "R-MMU-8847993", "R-CEL-190377", "R-MMU-9013507", "R-CFA-6811558", "R-MMU-1250347", "R-HSA-9028335", "R-HSA-1250196", "R-HSA-9674404", "R-HSA-9717323", "R-HSA-5654719", "R-HSA-9669926", "R-HSA-9032845", "R-HSA-9702636", "R-DME-5654699", "R-DRE-195399", "R-HSA-1963640", "R-DME-1250342", "R-HSA-5655291", "R-DME-428542", "R-MMU-109704", "R-DRE-1307965", "R-DRE-5654227", "R-HSA-5654712", "R-MMU-9028731", "R-RNO-9603381", "R-RNO-1250342", "R-RNO-1227986", "R-MMU-9706369", "R-HSA-9717319", "R-HSA-9665250", "R-HSA-190370", "R-CEL-77387", "R-DME-1474228", "R-MMU-5654726", "R-HSA-9669914", "R-MMU-212718", "R-HSA-5654219", "R-CEL-5654733", "R-DME-190375", "R-HSA-9634285", "R-HSA-187024", "R-HSA-74752", "R-CEL-5654689", "R-DRE-5654732", "R-HSA-9717326", "R-HSA-201556", "R-MMU-5654693", "R-CEL-9009391", "R-MMU-5654689", "R-HSA-9674428", "R-HSA-9856530", "R-HSA-9702569", "R-CEL-186797", "R-MMU-74749", "R-RNO-5654219", "R-DME-5654706", "R-DME-5654733", "R-HSA-9927426", "R-HSA-202733", "R-HSA-5654688", "R-DRE-1433557", "R-MMU-6785631", "R-MMU-182971", "R-MMU-9607240", "R-RNO-5654726", "R-HSA-187042", "R-HSA-9700645", "R-CEL-1253288", "R-CEL-9652282", "R-HSA-9758919", "R-DRE-194306", "R-DME-190371", "R-DRE-5654712", "R-RNO-74749", "R-CEL-187577", "R-HSA-2179392", "R-DRE-5218921", "R-HSA-9927418", "R-HSA-4420097", "R-DME-9749641", "R-RNO-190373", "R-RNO-202733", "R-CEL-1433559", "R-DME-1307965", "R-CEL-190370", "R-HSA-177929", "R-MMU-5654732", "R-DRE-5654733", "R-RNO-9034013", "R-RNO-9026527", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-5655302", "R-CEL-6785631", "R-CEL-5654693", "R-CEL-190322", "R-HSA-9018519", "R-RNO-3000171", "R-DRE-5654727", "R-DRE-5654720", "R-RNO-2404192", "R-DME-1227986", "R-HSA-9665244", "R-HSA-9665686", "R-DME-1236394", "R-RNO-5654693", "R-HSA-8853334", "R-RNO-8853659", "R-DRE-5654706", "R-HSA-8847993", "R-HSA-9830364", "R-CEL-190375", "R-HSA-5654732", "R-MMU-8853659", "R-CEL-177929", "R-HSA-2219530", "R-MMU-445144", "R-MMU-5654700", "R-HSA-2033515", "R-DME-5654688", "R-DRE-1433559", "R-RNO-77387", "R-DRE-210993", "R-DRE-190373", "R-MMU-9018519", "R-MMU-195399", "R-DRE-5654710", "R-DME-5654710", "R-DME-110478", "R-DME-445144", "R-HSA-9703648", "R-HSA-9620244", "R-RNO-1358803", "R-HSA-5654720", "R-HSA-1253288", "R-HSA-9702998", "R-DME-1963640", "R-RNO-9652282", "R-MMU-5654688", "R-RNO-9028731", "R-HSA-5654733", "R-HSA-5654704", "R-HSA-198203", "R-RNO-4420097", "R-DRE-190370", "R-CEL-201681", "R-HSA-8853884", "R-HSA-9669933", "R-HSA-449836", "R-HSA-1307965", "R-RNO-6785631", "R-CEL-8849469", "R-MMU-8856825", "R-DME-5654720", "R-HSA-9034015", "R-HSA-1250342", "R-HSA-9665245", "R-HSA-9032759", "R-DME-6811558", "R-DRE-5654687", "R-CFA-1433559", "R-HSA-8866910", "R-HSA-1236382", "R-GGA-6811558", "R-MMU-2428928", "R-DME-8856828", "R-RNO-5654687", "R-MMU-5654228", "R-HSA-195399", "R-RNO-170984", "R-MMU-5654719", "R-DME-5654221", "R-DRE-5654693", "R-MMU-1358803", "R-HSA-9028731", "R-DME-8856825", "R-RNO-1963640", "R-DME-77387", "R-HSA-4086400", "R-DME-5654228", "R-HSA-190373", "R-DRE-190322", "R-HSA-9032500", "R-HSA-1433557", "R-HSA-9717301", "R-RNO-195399", "R-CEL-180336", "R-GGA-1433559", "R-HSA-1236394", "R-CEL-190372", "R-MMU-2404192", "R-HSA-9830674", "R-HSA-9851151", "R-RNO-5218921", "R-DME-190322", "R-CEL-1963642", "R-MMU-177504", "R-RNO-5654720", "R-DRE-5654688", "R-RNO-1250196", "R-DME-5654726", "R-CEL-190371", "R-DRE-5654719", "R-RNO-186763", "R-MMU-8857538", "R-CEL-3000171", "R-MMU-9026527"], "pathways": ["R-RNO-190322:r:FGFR4 ligand binding and activation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-DRE-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9669921:r:KIT mutants bind TKIs", "R-HSA-9702624:r:sorafenib-resistant FLT3 mutants", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-HSA-77387:r:Insulin receptor recycling", "R-HSA-9669936:r:Sorafenib-resistant KIT mutants", "R-RNO-74752:r:Signaling by Insulin receptor", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-198745:r:Signalling to STAT3", "R-RNO-187042:r:TRKA activation by NGF", "R-HSA-1306955:r:GRB7 events in ERBB2 signaling", "R-DRE-190372:r:FGFR3c ligand binding and activation", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-201556:r:Signaling by ALK", "R-CEL-9607240:r:FLT3 Signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-DRE-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-MMU-1236394:r:Signaling by ERBB4", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-CEL-182971:r:EGFR downregulation", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-9702577:r:semaxanib-resistant FLT3 mutants", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-170984:r:ARMS-mediated activation", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-HSA-74713:r:IRS activation", "R-MMU-170968:r:Frs2-mediated activation", "R-DME-210991:r:Basigin interactions", "R-DME-109704:r:PI3K Cascade", "R-HSA-9702509:r:FLT3 mutants bind TKIs", "R-RNO-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-DRE-186763:r:Downstream signal transduction", "R-DME-190377:r:FGFR2b ligand binding and activation", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-CEL-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-DME-216083:r:Integrin cell surface interactions", "R-HSA-190377:r:FGFR2b ligand binding and activation", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-DME-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-170984:r:ARMS-mediated activation", "R-RNO-388844:r:Receptor-type tyrosine-protein phosphatases", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-DRE-201556:r:Signaling by ALK", "R-HSA-9702581:r:crenolanib-resistant FLT3 mutants", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DME-5654687:r:Downstream signaling of activated FGFR1", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-9702620:r:quizartinib-resistant FLT3 mutants", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-180336:r:SHC1 events in EGFR signaling", "R-CEL-1227986:r:Signaling by ERBB2", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-CEL-5654720:r:PI-3K cascade:FGFR4", "R-DRE-109704:r:PI3K Cascade", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-1839130:r:Signaling by activated point mutants of FGFR3", "R-DRE-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9669924:r:Masitinib-resistant KIT mutants", "R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9717329:r:lorlatinib-resistant ALK mutants", "R-CFA-201556:r:Signaling by ALK", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-190377:r:FGFR2b ligand binding and activation", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-GGA-1433557:r:Signaling by SCF-KIT", "R-CFA-1433557:r:Signaling by SCF-KIT", "R-HSA-2033519:r:Activated point mutants of FGFR2", "R-HSA-190372:r:FGFR3c ligand binding and activation", "R-RNO-1251985:r:Nuclear signaling by ERBB4", "R-DME-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-HSA-9706369:r:Negative regulation of FLT3", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-MMU-74713:r:IRS activation", "R-HSA-8852405:r:Signaling by MST1", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-HSA-9603505:r:NTRK3 as a dependence receptor", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-109704:r:PI3K Cascade", "R-DME-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-190322:r:FGFR4 ligand binding and activation", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-1227986:r:Signaling by ERBB2", "R-DRE-9851151:r:MDK and PTN in ALK signaling", "R-HSA-190322:r:FGFR4 ligand binding and activation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-190371:r:FGFR3b ligand binding and activation", "R-DME-177929:r:Signaling by EGFR", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-74749:r:Signal attenuation", "R-HSA-9669934:r:Sunitinib-resistant KIT mutants", "R-HSA-9842663:r:Signaling by LTK", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-HSA-8853336:r:Signaling by plasma membrane FGFR1 fusions", "R-RNO-74713:r:IRS activation", "R-RNO-5654689:r:PI-3K cascade:FGFR1", "R-MMU-190371:r:FGFR3b ligand binding and activation", "R-HSA-9034013:r:NTF3 activates NTRK3 signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DME-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-187706:r:Signalling to p38 via RIT and RIN", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-9680187:r:Signaling by extracellular domain mutants of KIT", "R-HSA-170968:r:Frs2-mediated activation", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-MMU-5654687:r:Downstream signaling of activated FGFR1", "R-MMU-1307965:r:betaKlotho-mediated ligand binding", "R-BTA-210993:r:Tie2 Signaling", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-2428928:r:IRS-related events triggered by IGF1R", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-GGA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-8853333:r:Signaling by FGFR2 fusions", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-CFA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-186797:r:Signaling by PDGF", "R-MMU-1433559:r:Regulation of KIT signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-1306955:r:GRB7 events in ERBB2 signaling", "R-DRE-5654689:r:PI-3K cascade:FGFR1", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-74752:r:Signaling by Insulin receptor", "R-HSA-9669929:r:Regorafenib-resistant KIT mutants", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-HSA-190375:r:FGFR2c ligand binding and activation", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-198203:r:PI3K/AKT activation", "R-MMU-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-187042:r:TRKA activation by NGF", "R-RNO-170968:r:Frs2-mediated activation", "R-CFA-5673001:r:RAF/MAP kinase cascade", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-HSA-2023837:r:Signaling by FGFR2 amplification mutants", "R-DME-190372:r:FGFR3c ligand binding and activation", "R-DRE-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-201681:r:TCF dependent signaling in response to WNT", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DME-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-CEL-216083:r:Integrin cell surface interactions", "R-HSA-9717264:r:ASP-3026-resistant ALK mutants", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-DME-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-210993:r:Tie2 Signaling", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-CEL-180292:r:GAB1 signalosome", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-9024909:r:BDNF activates NTRK2 (TRKB) signaling", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-CEL-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-DRE-5654704:r:SHC-mediated cascade:FGFR3", "R-DME-1250196:r:SHC1 events in ERBB2 signaling", "R-CEL-186763:r:Downstream signal transduction", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-9034013:r:NTF3 activates NTRK3 signaling", "R-DRE-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DRE-5654700:r:FRS-mediated FGFR2 signaling", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-MMU-5654710:r:PI-3K cascade:FGFR3", "R-HSA-1839128:r:FGFR4 mutant receptor activation", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9702605:r:pexidartinib-resistant FLT3 mutants", "R-CEL-8849472:r:PTK6 Down-Regulation", "R-HSA-167044:r:Signalling to RAS", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-DME-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-DRE-9842663:r:Signaling by LTK", "R-HSA-5654687:r:Downstream signaling of activated FGFR1", "R-DME-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-109704:r:PI3K Cascade", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-MMU-9842663:r:Signaling by LTK", "R-HSA-9702614:r:ponatinib-resistant FLT3 mutants", "R-MMU-198203:r:PI3K/AKT activation", "R-DRE-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-MMU-8852405:r:Signaling by MST1", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-DME-190374:r:FGFR1c and Klotho ligand binding and activation", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-DME-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-1307965:r:betaKlotho-mediated ligand binding", "R-CEL-5654710:r:PI-3K cascade:FGFR3", "R-DRE-449836:r:Other interleukin signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9025046:r:NTF3 activates NTRK2 (TRKB) signaling", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-9674403:r:Regorafenib-resistant PDGFR mutants", "R-DME-180292:r:GAB1 signalosome", "R-HSA-1839122:r:Signaling by activated point mutants of FGFR1", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-HSA-9645135:r:STAT5 Activation", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-RNO-186797:r:Signaling by PDGF", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-DME-5654689:r:PI-3K cascade:FGFR1", "R-CEL-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-2428928:r:IRS-related events triggered by IGF1R", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-DRE-190375:r:FGFR2c ligand binding and activation", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-RNO-1236394:r:Signaling by ERBB4", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190373:r:FGFR1c ligand binding and activation", "R-DRE-5654695:r:PI-3K cascade:FGFR2", "R-DME-179812:r:GRB2 events in EGFR signaling", "R-RNO-449836:r:Other interleukin signaling", "R-HSA-9702600:r:midostaurin-resistant FLT3 mutants", "R-MMU-177929:r:Signaling by EGFR", "R-RNO-1306955:r:GRB7 events in ERBB2 signaling", "R-HSA-9607240:r:FLT3 Signaling", "R-CEL-8849470:r:PTK6 Regulates Cell Cycle", "R-DRE-186797:r:Signaling by PDGF", "R-HSA-9026357:r:NTF4 activates NTRK2 (TRKB) signaling", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-RNO-2428933:r:SHC-related events triggered by IGF1R", "R-DME-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-167021:r:PLC-gamma1 signalling", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9702596:r:lestaurtinib-resistant FLT3 mutants", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-210993:r:Tie2 Signaling", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-9669935:r:Signaling by juxtamembrane domain KIT mutants", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-9674401:r:Sunitinib-resistant PDGFR mutants", "R-CEL-5654695:r:PI-3K cascade:FGFR2", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-9702632:r:sunitinib-resistant FLT3 mutants", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-CEL-190373:r:FGFR1c ligand binding and activation", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-9669917:r:Imatinib-resistant KIT mutants", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-DME-190370:r:FGFR1b ligand binding and activation", "R-MMU-77387:r:Insulin receptor recycling", "R-HSA-182971:r:EGFR downregulation", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-5654689:r:PI-3K cascade:FGFR1", "R-RNO-445144:r:Signal transduction by L1", "R-HSA-1839120:r:Signaling by FGFR1 amplification mutants", "R-HSA-9674396:r:Imatinib-resistant PDGFR mutants", "R-DME-433692:r:Proton-coupled monocarboxylate transport", "R-DME-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-190375:r:FGFR2c ligand binding and activation", "R-HSA-9702590:r:gilteritinib-resistant FLT3 mutants", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-9609690:r:HCMV Early Events", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-190372:r:FGFR3c ligand binding and activation", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-8851708:r:Signaling by FGFR2 IIIa TM", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-9703009:r:tamatinib-resistant FLT3 mutants", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-5654695:r:PI-3K cascade:FGFR2", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DRE-190371:r:FGFR3b ligand binding and activation", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-DME-182971:r:EGFR downregulation", "R-MMU-186797:r:Signaling by PDGF", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DME-5673001:r:RAF/MAP kinase cascade", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-CFA-9851151:r:MDK and PTN in ALK signaling", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-190374:r:FGFR1c and Klotho ligand binding and activation", "R-GGA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-HSA-9717316:r:alectinib-resistant ALK mutants", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-DRE-190377:r:FGFR2b ligand binding and activation", "R-HSA-190374:r:FGFR1c and Klotho ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-190377:r:FGFR2b ligand binding and activation", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-9028335:r:Activated NTRK2 signals through 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signals through PI3K", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-9717319:r:brigatinib-resistant ALK mutants", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-CEL-77387:r:Insulin receptor recycling", "R-DME-1474228:r:Degradation of the extracellular matrix", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-9669914:r:Dasatinib-resistant KIT mutants", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-190375:r:FGFR2c ligand binding and activation", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-187024:r:NGF-independant TRKA activation", "R-HSA-74752:r:Signaling by Insulin receptor", "R-CEL-5654689:r:PI-3K cascade:FGFR1", "R-DRE-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-9717326:r:crizotinib-resistant ALK mutants", "R-HSA-201556:r:Signaling by ALK", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-HSA-9674428:r:PDGFR mutants bind TKIs", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9702569:r:KW2449-resistant FLT3 mutants", "R-CEL-186797:r:Signaling by PDGF", "R-MMU-74749:r:Signal attenuation", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-DME-5654706:r:FRS-mediated FGFR3 signaling", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-DRE-1433557:r:Signaling by SCF-KIT", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", 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cascade:FGFR4", "R-RNO-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-DME-1227986:r:Signaling by ERBB2", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DME-1236394:r:Signaling by ERBB4", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-8853334:r:Signaling by FGFR3 fusions in cancer", "R-RNO-8853659:r:RET signaling", "R-DRE-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-CEL-190375:r:FGFR2c ligand binding and activation", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-8853659:r:RET signaling", "R-CEL-177929:r:Signaling by EGFR", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-445144:r:Signal transduction by L1", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-2033515:r:t(4;14) translocations of FGFR3", 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"R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-DME-77387:r:Insulin receptor recycling", "R-HSA-4086400:r:PCP/CE pathway", "R-DME-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-DRE-190322:r:FGFR4 ligand binding and activation", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-HSA-9717301:r:NVP-TAE684-resistant ALK mutants", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-GGA-1433559:r:Regulation of KIT signaling", "R-HSA-1236394:r:Signaling by ERBB4", "R-CEL-190372:r:FGFR3c ligand binding and activation", "R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-DME-190322:r:FGFR4 ligand binding and activation", "R-CEL-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-RNO-5654720:r:PI-3K cascade:FGFR4", "R-DRE-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-DME-5654726:r:Negative regulation of FGFR1 signaling", "R-CEL-190371:r:FGFR3b ligand binding and activation", "R-DRE-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-CEL-3000171:r:Non-integrin membrane-ECM interactions", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1"], "type": "Family"}, "IPR050124": {"description": "tRNA CCA-adding enzyme", "go_ids": [], "go_terms": [], "name": "tRNA_CCA-adding_enzyme", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", 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"PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-5138:t:fatty acid beta-oxidation IV (unsaturated, even number)", "PWY-8347:t:adipate biosynthesis", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7094:t:fatty acid salvage", "PWY-8179:t:platensimycin biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5177:t:glutaryl-CoA degradation", "PWY-7779:t:methyl tert-butyl ether degradation", "R-RNO-1482798:r:Acyl chain remodeling of CL", "R-SSC-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77288:r:mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "R-SSC-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-SSC-1482798:r:Acyl chain remodeling of CL", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-HSA-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-HSA-1482798:r:Acyl chain remodeling of CL", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-SSC-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-MMU-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-SSC-77285:r:Beta oxidation of myristoyl-CoA to lauroyl-CoA", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-1482798:r:Acyl chain remodeling of CL", "R-HSA-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "R-SSC-77305:r:Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "type": "Family"}, "IPR050137": {"description": "PyrR bifunctional", "go_ids": [], "go_terms": [], "name": "PyrR_bifunctional", "pathway_ids": ["PWY-7183"], "pathways": ["PWY-7183:t:pyrimidine nucleobases salvage I"], "type": "Family"}, "IPR050138": {"description": "Dihydroorotase/Allantoinase hydrolase-like", "go_ids": [], "go_terms": [], "name": "DHOase/Allantoinase_Hydrolase", "pathway_ids": ["PWY-7791", "PWY-5686", "PWY-7790"], "pathways": ["PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II"], "type": "Family"}, "IPR050139": {"description": "Guanosine monophosphate reductase", "go_ids": [], "go_terms": [], "name": "GMP_reductase", "pathway_ids": ["R-HSA-74217", "R-HSA-9854909", "R-RNO-74217", "R-CEL-74217", "R-MMU-74217"], "pathways": ["R-HSA-74217:r:Purine salvage", "R-HSA-9854909:r:Regulation of MITF-M dependent genes involved in invasion", "R-RNO-74217:r:Purine salvage", "R-CEL-74217:r:Purine salvage", "R-MMU-74217:r:Purine salvage"], "type": "Family"}, "IPR050140": {"description": "SRY-related HMG-box transcription factor-like", "go_ids": [], "go_terms": [], "name": "SRY-related_HMG-box_TF-like", "pathway_ids": ["R-MMU-3769402", "R-DRE-3769402", "R-HSA-2892245", "R-HSA-3769402", "R-HSA-9937080", "R-HSA-452723", "R-HSA-6785807", "R-CEL-3769402", "R-HSA-9823739", "R-DME-3769402", "R-HSA-9754189", "R-XTR-3769402", "R-HSA-9827857", "R-HSA-9832991", "R-HSA-9823730", "R-HSA-9926550", "R-SSC-3769402", "R-HSA-9856649", "R-RNO-3769402", "R-HSA-8986944", "R-HSA-2892247", "R-CFA-3769402", "R-HSA-9690406", "R-HSA-9834899"], "pathways": ["R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2892245:r:POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9823739:r:Formation of the anterior neural plate", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9754189:r:Germ layer formation at gastrulation", "R-XTR-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9827857:r:Specification of primordial germ cells", "R-HSA-9832991:r:Formation of the posterior neural plate", "R-HSA-9823730:r:Formation of definitive endoderm", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-SSC-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-CFA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-HSA-9834899:r:Specification of the neural plate border"], "type": "Family"}, "IPR050141": {"description": "Glutamate--cysteine ligase type 2, YbdK subfamily", "go_ids": [], "go_terms": [], "name": "GCL_type2/YbdK_subfam", "pathway_ids": ["PWY-8043", "PWY-6840", "PWY-7255"], "pathways": ["PWY-8043:t:ophthalmate biosynthesis", "PWY-6840:t:homoglutathione biosynthesis", "PWY-7255:t:ergothioneine biosynthesis I (bacteria)"], "type": "Family"}, "IPR050142": {"description": "Floral homeotic protein/MADs-box-like transcription factors", "go_ids": [], "go_terms": [], "name": "MADS-box-like", "pathway_ids": ["R-SPO-9031628", "R-HSA-9768777", "R-HSA-9733709", "R-MMU-9031628", "R-HSA-5663220", "R-DDI-9031628", "R-DME-5663220", "R-HSA-9031628", "R-CEL-9031628", "R-HSA-9634638", "R-SPO-525793", "R-MMU-5663220", "R-SCE-9031628"], "pathways": ["R-SPO-9031628:r:NGF-stimulated transcription", "R-HSA-9768777:r:Regulation of NPAS4 gene transcription", "R-HSA-9733709:r:Cardiogenesis", "R-MMU-9031628:r:NGF-stimulated transcription", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DDI-9031628:r:NGF-stimulated transcription", "R-DME-5663220:r:RHO GTPases Activate Formins", "R-HSA-9031628:r:NGF-stimulated transcription", "R-CEL-9031628:r:NGF-stimulated transcription", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-SPO-525793:r:Myogenesis", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-SCE-9031628:r:NGF-stimulated transcription"], "type": "Family"}, "IPR050143": {"description": "Tripartite motif-containing", "go_ids": [], "go_terms": [], "name": "TRIM/RBCC", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-MMU-3232142", "R-HSA-901032", "R-HSA-445355", "R-HSA-9705671", "R-HSA-168928", "R-HSA-1834941", "R-BTA-9755511", "R-HSA-5689896", "R-HSA-933542", "R-HSA-9660826", "R-MMU-3134975", "R-HSA-9755511", "R-HSA-936440", "R-MMU-9755511", "R-HSA-983168", "R-MMU-8948751", "R-RNO-844456", "R-MMU-844456", "R-BTA-3134975", "R-HSA-3232142", "R-HSA-918233", "R-HSA-933541", "R-HSA-933543", "R-HSA-877300", "R-HSA-9635465", "R-HSA-3134975", "R-HSA-8948751", "R-MMU-983168", "R-RNO-983168", "R-HSA-844456"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9635465:r:Suppression of apoptosis", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Family"}, "IPR050144": {"description": "AAE Transporter", "go_ids": [], "go_terms": [], "name": "AAE_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050145": {"description": "Centrin/CML-like", "go_ids": [], "go_terms": [], "name": "Centrin_CML-like", "pathway_ids": ["R-CEL-425561", "R-CEL-111957", "R-HSA-9646399", "R-DDI-5696395", "R-HSA-3108214", "R-CEL-5626467", "R-HSA-380284", "R-CEL-9619229", "R-DDI-9646399", "R-CEL-438066", "R-BTA-3108214", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-BTA-380259", "R-HSA-2565942", "R-HSA-380320", "R-SPO-5696395", "R-CEL-70221", "R-CEL-5607763", "R-MMU-5696395", "R-CEL-451308", "R-BTA-2565942", "R-CEL-111933", "R-BTA-5620912", "R-CEL-4086398", "R-BTA-380320", "R-CEL-111932", "R-MMU-5696394", "R-HSA-9615710", "R-CEL-1474151", "R-BTA-5696395", "R-HSA-5620912", "R-MMU-5620912", "R-BTA-380284", "R-CEL-936837", "R-CEL-203615", "R-CEL-163615", "R-CEL-1855204", "R-CEL-418359", "R-MMU-380259", "R-DME-6798695", "R-BTA-5696394", "R-SPO-5696394", "R-CEL-114608", "R-MMU-380270", "R-CEL-442729", "R-HSA-380270", "R-CEL-9648002", "R-BTA-8854518", "R-CEL-5578775", "R-BTA-380270", "R-DDI-5696394", "R-HSA-5696395", "R-HSA-5696394", "R-HSA-9613829", "R-MMU-8854518", "R-CEL-9009391", "R-MMU-3108214", "R-CEL-2514859", "R-CEL-2871809", "R-HSA-380259", "R-CEL-5218920", "R-CEL-9856530"], "pathways": ["R-CEL-425561:r:Sodium/Calcium exchangers", "R-CEL-111957:r:Cam-PDE 1 activation", "R-HSA-9646399:r:Aggrephagy", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-9619229:r:Activation of RAC1 downstream of NMDARs", "R-DDI-9646399:r:Aggrephagy", "R-CEL-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-BTA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-70221:r:Glycogen breakdown (glycogenolysis)", "R-CEL-5607763:r:CLEC7A (Dectin-1) induces NFAT activation", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-451308:r:Activation of Ca-permeable Kainate Receptor", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-111933:r:Calmodulin induced events", "R-BTA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-CEL-4086398:r:Ca2+ pathway", "R-BTA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-CEL-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9615710:r:Late endosomal microautophagy", "R-CEL-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-BTA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-936837:r:Ion transport by P-type ATPases", "R-CEL-203615:r:eNOS activation", "R-CEL-163615:r:PKA activation", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-418359:r:Reduction of cytosolic Ca++ levels", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-DME-6798695:r:Neutrophil degranulation", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-114608:r:Platelet degranulation", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-442729:r:CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-CEL-9648002:r:RAS processing", "R-BTA-8854518:r:AURKA Activation by TPX2", "R-CEL-5578775:r:Ion homeostasis", "R-BTA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Family"}, "IPR050146": {"description": "Type-I 3-dehydroquinase", "go_ids": [], "go_terms": [], "name": "Type-I_3-dehydroquinase", "pathway_ids": ["PWY-6707", "PWY-6163", "PWY-6416"], "pathways": ["PWY-6707:t:gallate biosynthesis", "PWY-6163:t:chorismate biosynthesis from 3-dehydroquinate", "PWY-6416:t:quinate degradation II"], "type": "Family"}, "IPR050147": {"description": "Serine/Threonine Dehydratase", "go_ids": [], "go_terms": [], "name": "Ser/Thr_Dehydratase", "pathway_ids": ["R-HSA-8849175", "R-DDI-977347", "R-MMU-977347", "R-SCE-8849175", "R-RNO-977347", "R-SCE-977347", "R-DDI-8849175", "R-MMU-8849175", "R-RNO-8849175", "R-HSA-977347"], "pathways": ["R-HSA-8849175:r:Threonine catabolism", "R-DDI-977347:r:Serine metabolism", "R-MMU-977347:r:Serine metabolism", "R-SCE-8849175:r:Threonine catabolism", "R-RNO-977347:r:Serine metabolism", "R-SCE-977347:r:Serine metabolism", "R-DDI-8849175:r:Threonine catabolism", "R-MMU-8849175:r:Threonine catabolism", "R-RNO-8849175:r:Threonine catabolism", "R-HSA-977347:r:Serine metabolism"], "type": "Family"}, "IPR050148": {"description": "Terpene synthase-like", "go_ids": ["GO:0010333", "GO:0016114"], "go_terms": ["GO:0010333:terpene synthase activity:F", "GO:0016114:terpenoid biosynthetic process:P"], "name": "Terpene_synthase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050150": {"description": "Immunoglobulin Variable Light Chain", "go_ids": [], "go_terms": [], "name": "IgV_Light_Chain", "pathway_ids": ["R-HSA-173623", "R-HSA-2871796", "R-HSA-2168880", "R-HSA-2029485", "R-HSA-2029481", "R-MMU-173623", "R-MMU-2871796", "R-HSA-2454202", "R-HSA-2871837", "R-HSA-977606", "R-MMU-202733", "R-MMU-2029485", "R-HSA-2730905", "R-HSA-166663", "R-MMU-2168880", "R-MMU-977606", "R-HSA-983695", "R-HSA-2871809", "R-HSA-9679191", "R-HSA-2029482", "R-HSA-5690714", "R-MMU-983695", "R-MMU-5690714", "R-MMU-2454202", "R-MMU-2029482", "R-GGA-2132286", "R-MMU-2029481", "R-MMU-198933", "R-MMU-2871837", "R-MMU-2871809", "R-HSA-198933", "R-MMU-2730905", "R-HSA-9664422", "R-HSA-9664323", "R-HSA-202733", "R-GGA-2132263"], "pathways": ["R-HSA-173623:r:Classical antibody-mediated complement activation", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-2029481:r:FCGR activation", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", 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and a non-Lymphoid cell", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-GGA-2132263:r:Creation of classical C3 convertase"], "type": "Family"}, "IPR050151": {"description": "Class-I pyridine nucleotide-disulfide oxidoreductase", "go_ids": [], "go_terms": [], "name": "Class-I_Pyr_Nuc-Dis_Oxidored", "pathway_ids": ["R-DDI-9859138", "R-MMU-9837999", "R-SPO-9861559", "R-BTA-9858328", "R-SPO-9853506", "R-HSA-9853506", "R-BTA-5362517", "R-HSA-9858328", "R-DDI-9858328", "R-HSA-9636383", "R-MMU-9861559", "R-BTA-204174", "R-BTA-6783984", "R-MMU-70895", "R-BTA-9859138", "R-BTA-9837999", "R-HSA-1222541", "R-CEL-9861559", 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"R-DDI-901032", "R-RNO-8866427", "R-RNO-9929356", "R-BTA-8863795", "R-BTA-156827", "R-GGA-450302", "R-MMU-209543", "R-SSC-9645460", "R-HSA-9918432", "R-BTA-5687128", "R-HSA-5678895", "R-BTA-1358803", "R-MMU-2559580", "R-CFA-5685942", "R-RNO-174184", "R-GGA-5656169", "R-BTA-8866652", "R-MMU-4641257", "R-SCE-8856825", "R-CFA-179409", "R-BTA-9770562", "R-HSA-975110", "R-GGA-1253288", "R-MMU-2173788", "R-CEL-5689896", "R-BTA-5654726", "R-DDI-8866654", "R-DME-9954709", "R-CFA-8948751", "R-HSA-977225", "R-CFA-8866652", "R-DME-8866427", "R-CFA-8941858", "R-BTA-5654727", "R-MMU-9755511", "R-RNO-2173788", "R-BTA-937072", "R-BTA-2672351", "R-GGA-8863795", "R-MMU-9931295", "R-RNO-5689603", "R-RNO-8849469", "R-CFA-4608870", "R-GGA-5668541", "R-RNO-937039", "R-DDI-69017", "R-MMU-5655862", "R-BTA-8948751", "R-HSA-9013973", "R-RNO-9929491", "R-CEL-5675221", "R-BTA-5205685", "R-CFA-5607764", "R-HSA-2894862", "R-HSA-5632684", "R-CFA-209543", "R-SSC-2467813", "R-SSC-2871837", "R-HSA-8876493", "R-RNO-5607764", "R-GGA-2672351", "R-MMU-5654733", "R-SSC-5676590", "R-RNO-182971", "R-RNO-6781823", "R-GGA-5689603", "R-GGA-937041", "R-SSC-937039", "R-BTA-1234176", "R-RNO-5693565", "R-MMU-69017", "R-RNO-5655862", "R-CFA-2672351", "R-SSC-69231", "R-CFA-69481", "R-CFA-8939902", "R-RNO-5689901", "R-RNO-8863795", "R-SSC-5687128", "R-DDI-179409", "R-CEL-110320", "R-CFA-8866427", "R-DME-2467813", "R-RNO-937042", "R-BTA-936964", "R-BTA-2173795", "R-SSC-110312", "R-BTA-5689901", "R-MMU-6804760", "R-RNO-4641258", "R-HSA-9931269", "R-MMU-975144", "R-CEL-2173788", "R-CEL-917937", "R-HSA-2408557", "R-MMU-450321", "R-CEL-6782210", "R-BTA-5684264", "R-DME-9861718", "R-CEL-9648002", "R-BTA-5675221", "R-SCE-8951664", "R-SSC-179409", "R-DME-75815", "R-CFA-4641263", "R-GGA-209543", "R-GGA-2559582", "R-DME-182971", "R-CFA-909733", "R-GGA-983168", "R-HSA-5610785", "R-DME-1358803", "R-SSC-5689896", "R-SSC-69017", "R-SSC-2173795", "R-HSA-9824878", "R-GGA-5610785", "R-CEL-983168", "R-MMU-8939236", "R-DME-937039", "R-RNO-4641257", "R-BTA-72706", "R-DDI-5689603", "R-SSC-174154", "R-MMU-532668", "R-HSA-5689877", "R-SSC-9020702", "R-GGA-9033241", "R-MMU-202424", "R-BTA-5632684", "R-DDI-5687128", "R-RNO-9664873", "R-CFA-9033241", "R-CFA-8852276", "R-BTA-9931269", "R-SSC-9708530", "R-MMU-6804757", "R-CFA-5696400", "R-BTA-1295596", "R-CEL-9931269", "R-MMU-156827", "R-SSC-937041", "R-RNO-6807004", "R-MMU-8939902", "R-CFA-5689877", "R-CFA-9706369", "R-BTA-917729", "R-CFA-5357905", "R-SSC-174048", "R-HSA-8875360", "R-HSA-8939236", "R-BTA-2122948", "R-BTA-983168", "R-RNO-5654726", "R-DME-6781823", "R-GGA-9664873", "R-CEL-912631", "R-DDI-9646399", "R-SSC-5654732", "R-MMU-69541", "R-DDI-5632684", "R-HSA-975956", "R-RNO-2173795", "R-SSC-901032", "R-CFA-2173791", "R-HSA-4641257", "R-RNO-202424", "R-HSA-174113", "R-BTA-9762114", "R-GGA-2173795", "R-CFA-9954709", "R-HSA-5656121", "R-GGA-5696400", "R-HSA-2173789", "R-RNO-975957", "R-HSA-9694493", "R-RNO-917937", "R-HSA-9755511", "R-RNO-9013507", "R-RNO-9931269", "R-BTA-912631", "R-DME-3134975", "R-GGA-174178", "R-CFA-9646399", "R-MMU-8866427", "R-BTA-6783310", "R-MMU-9931269", "R-DDI-68949", "R-SSC-72689", "R-RNO-445989", "R-HSA-8948751", "R-DDI-9758274", "R-RNO-5689896", "R-MMU-5696397", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-GGA-9931295", "R-CFA-110320", "R-DME-156827", "R-DDI-9755511", "R-HSA-2122948", "R-GGA-573298", "R-CFA-9762114", "R-HSA-2559585", "R-SSC-174178", "R-RNO-72689", "R-SSC-5696397", "R-CEL-936440", "R-GGA-69541", "R-DME-8856828", "R-CFA-450408", "R-MMU-5689603", "R-GGA-353299", "R-HSA-2173796", "R-SSC-2672351", "R-SSC-6804757", "R-RNO-4608870", "R-GGA-5696397", "R-MMU-8849469", "R-BTA-9664873", "R-SSC-5696394", "R-BTA-174048", "R-RNO-5684264", "R-CEL-5655862", "R-GGA-5357905", "R-BTA-6804760", "R-DME-532668", "R-CFA-5689896", "R-BTA-1799339", "R-HSA-5668541", "R-DME-5632684", "R-DME-432395", "R-HSA-9705462", "R-CFA-9824878", "R-MMU-936440", "R-MMU-9758274", "R-CFA-937042", "R-GGA-437986", "R-DDI-174178", "R-SSC-9954716", "R-DDI-9954716", "R-BTA-5689880", "R-MMU-9770562", "R-HSA-9010553", "R-CEL-8941858", "R-CEL-5357905", "R-CEL-532668", "R-DME-5696394", "R-BTA-6804757", "R-BTA-6804756", "R-SSC-912631", "R-HSA-450408", "R-DME-5654727", "R-MMU-8866654", "R-HSA-532668", "R-GGA-437980", "R-DME-432524", "R-CFA-5656169", "R-MMU-2173796", "R-RNO-5675221", "R-HSA-162588", "R-DDI-5696394", "R-SSC-8939236", "R-HSA-179409", "R-SSC-9932298", "R-DME-9010553", "R-CFA-983168", "R-HSA-201681", "R-DME-202424", "R-DME-187577", "R-DME-5689901", "R-SSC-450408", "R-GGA-9755511", "R-DME-72649", "R-HSA-3785653", "R-BTA-4608870", "R-SSC-1358803", "R-MMU-349425", "R-BTA-2871837", "R-DME-9770562", "R-GGA-6804756", "R-BTA-174154", "R-MMU-2672351", "R-DDI-69601", "R-CFA-6804760", "R-BTA-8866427", "R-DME-8863795", "R-GGA-1295596", "R-GGA-532668", "R-DDI-5689880", "R-MMU-5696400", "R-SSC-8941858", "R-CFA-8849469", "R-BTA-8849469", "R-GGA-912631", "R-GGA-9929491", "R-CFA-9954716", "R-MMU-2173789", "R-MMU-209560", "R-CEL-9755511", "R-BTA-5696394", "R-CFA-201681", "R-MMU-5675482", "R-MMU-5656169", "R-HSA-72764", "R-BTA-4641263", "R-BTA-9929356", "R-SSC-187577", "R-MMU-5676590", "R-GGA-9954709", "R-SSC-9648002", "R-GGA-8866427", "R-HSA-5357956", "R-BTA-5656121", "R-RNO-5654733", "R-CFA-3134975", "R-DME-6782210", "R-GGA-917729", "R-CFA-174178", "R-HSA-9725370", "R-HSA-8849469", "R-GGA-9645460", "R-MMU-5632684", "R-SSC-5675221", "R-BTA-5610785", "R-SSC-4641263", "R-SSC-5655862", "R-MMU-2467813", "R-MMU-2173791", "R-BTA-9824878", "R-DDI-5693565", "R-BTA-9033241", "R-CEL-917729", "R-DME-174113", "R-CFA-9664873", "R-GGA-382556", "R-BTA-9758274", "R-GGA-8854050", "R-DDI-9954714", "R-BTA-5675482", "R-DME-8948747", "R-MMU-9929356", "R-HSA-5205685", "R-CEL-9954716", "R-CEL-110312", "R-BTA-901032", "R-CFA-9755511", "R-CEL-2173795", "R-BTA-174084", "R-RNO-156827", "R-BTA-2559582", "R-HSA-5675482", "R-BTA-9708530", "R-CEL-2173796", "R-DDI-8948751", "R-CFA-6782135", "R-GGA-434131", "R-CFA-4641257", "R-DDI-174048", "R-SSC-1234176", "R-SSC-68949", "R-MMU-9708530", "R-GGA-68867", "R-DDI-450302", "R-RNO-450302", "R-BTA-8948747", "R-DME-209447", "R-BTA-9646399", "R-CFA-1253288", "R-BTA-72649", "R-CFA-174184", "R-DME-2871837", "R-MMU-8863795", "R-DDI-975956", "R-DME-937042", "R-DDI-6782135", "R-CFA-174154", "R-CFA-5668541", "R-DDI-8948747", "R-MMU-110312", "R-CFA-5675482", "R-BTA-2173796", "R-GGA-5655862", "R-HSA-2565942", "R-CFA-5689880", "R-BTA-5654733", "R-MMU-937039", "R-RNO-5610780", "R-SSC-9706369", "R-GGA-8939902", "R-GGA-2122948", "R-DME-5689603", "R-MMU-901032", "R-MMU-5658442", "R-SSC-8856825", "R-MMU-168638", "R-HSA-174084", "R-SSC-6804760", "R-CFA-195253", "R-MMU-4608870", "R-BTA-5610780", "R-DME-72695", "R-MMU-72702", "R-RNO-8856825", "R-SSC-2559582", "R-DME-5675482", "R-GGA-174048", "R-HSA-72689", "R-GGA-4641263", "R-CEL-5696397", "R-SSC-5357956", "R-BTA-9954714", "R-GGA-5654732", "R-HSA-9706377", "R-RNO-2559580", "R-DDI-349425", "R-HSA-69017", "R-BTA-9020702", "R-BTA-975956", "R-RNO-9766229", "R-HSA-9014325", "R-SSC-5632684", "R-GGA-3134975", "R-SSC-182971", "R-HSA-9637628", "R-DDI-450321"], "pathways": ["R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-SSC-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SSC-209543:r:p75NTR recruits signalling complexes", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-69481:r:G2/M Checkpoints", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-5689877:r:Josephin domain DUBs", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-SSC-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CFA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-382556:r:ABC-family proteins mediated transport", "R-SSC-450302:r:activated TAK1 mediates p38 MAPK activation", "R-CEL-5654727:r:Negative regulation of FGFR2 signaling", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-1295596:r:Spry regulation of FGF signaling", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-9648002:r:RAS processing", "R-RNO-72649:r:Translation initiation complex formation", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9646399:r:Aggrephagy", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9664873:r:Pexophagy", "R-GGA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-917937:r:Iron uptake and transport", "R-SSC-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-GGA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-GGA-8951664:r:Neddylation", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-BTA-5656169:r:Termination of translesion DNA synthesis", "R-GGA-9770562:r:mRNA Polyadenylation", "R-HSA-9615710:r:Late endosomal microautophagy", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-917937:r:Iron uptake and transport", "R-MMU-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SSC-6783310:r:Fanconi Anemia Pathway", "R-SSC-6782135:r:Dual incision in TC-NER", "R-DDI-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-9646399:r:Aggrephagy", "R-CFA-182971:r:EGFR downregulation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SSC-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-MMU-6807004:r:Negative regulation of MET activity", "R-SSC-5696400:r:Dual Incision in GG-NER", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SSC-9770562:r:mRNA Polyadenylation", "R-GGA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-GGA-433822:r:NFkB and MAPK activation mediated by TRAF6", "R-GGA-5689896:r:Ovarian tumor domain proteases", "R-DDI-5358346:r:Hedgehog ligand biogenesis", "R-DME-209560:r:NF-kB is activated and signals survival", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CFA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-CFA-5654727:r:Negative regulation of FGFR2 signaling", "R-CFA-5675221:r:Negative regulation of MAPK pathway", "R-CFA-69541:r:Stabilization of p53", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-GGA-69231:r:Cyclin D associated events in G1", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-1227888:r:Negative Regulation of MDA5 signaling", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-5675482:r:Regulation of necroptotic cell death", "R-SSC-5656169:r:Termination of translesion DNA synthesis", "R-DME-110320:r:Translesion Synthesis by POLH", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-1253288:r:Downregulation of ERBB4 signaling", "R-DME-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-GGA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CFA-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-912631:r:Regulation of signaling by CBL", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-69231:r:Cyclin D associated events in G1", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-110312:r:Translesion synthesis by REV1", "R-CFA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-GGA-9861718:r:Regulation of pyruvate metabolism", "R-CFA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-5610785:r:GLI3 is 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"R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-912631:r:Regulation of signaling by CBL", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-2559585:r:Oncogene Induced Senescence", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-CFA-6807004:r:Negative regulation of MET activity", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-9664873:r:Pexophagy", "R-CFA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-SSC-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-433871:r:TRAF6 mediated induction of proinflammatory cytokines", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-RNO-5656121:r:Translesion synthesis by POLI", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-SSC-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CFA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-6782135:r:Dual incision in TC-NER", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-GGA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-4641257:r:Degradation of AXIN", "R-SPO-8951664:r:Neddylation", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SSC-5656121:r:Translesion synthesis by POLI", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-BTA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-GGA-187577:r:SCF(Skp2)-mediated 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"R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-9664873:r:Pexophagy", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CFA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-RNO-201681:r:TCF dependent signaling in response to WNT", "R-RNO-110312:r:Translesion synthesis by REV1", "R-SSC-2173788:r:Downregulation of TGF-beta receptor signaling", "R-GGA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-CFA-8951664:r:Neddylation", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9828211:r:Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-SSC-909733:r:Interferon alpha/beta signaling", "R-DME-912631:r:Regulation of signaling by CBL", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-SSC-937042:r:IRAK2 mediated activation of TAK1 complex", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CEL-5654732:r:Negative regulation of FGFR3 signaling", "R-CFA-5656121:r:Translesion synthesis by POLI", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-GGA-6782135:r:Dual incision in TC-NER", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SSC-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SSC-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CFA-9648002:r:RAS processing", "R-SSC-1169091:r:Activation of NF-kappaB in B cells", "R-CFA-9932298:r:Degradation of CRY and PER proteins", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CFA-382556:r:ABC-family proteins mediated transport", "R-HSA-9735869:r:SARS-CoV-1 modulates host translation 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"R-CFA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-CFA-8863795:r:Downregulation of ERBB2 signaling", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5654732:r:Negative regulation of FGFR3 signaling", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CFA-9861718:r:Regulation of pyruvate metabolism", "R-CFA-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-CFA-5689603:r:UCH proteinases", "R-GGA-5632684:r:Hedgehog 'on' state", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DME-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-182971:r:EGFR downregulation", "R-RNO-5654732:r:Negative regulation of FGFR3 signaling", "R-DME-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-BTA-182971:r:EGFR downregulation", "R-BTA-6782135:r:Dual incision in TC-NER", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-GGA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-GGA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-CFA-5655862:r:Translesion synthesis by POLK", "R-CFA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-5654733:r:Negative regulation of FGFR4 signaling", "R-BTA-917937:r:Iron uptake and transport", "R-SSC-110314:r:Recognition of DNA damage by 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"R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CFA-205043:r:NRIF signals cell death from the nucleus", "R-SSC-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9664873:r:Pexophagy", "R-MMU-917937:r:Iron uptake and transport", "R-SSC-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-SSC-917937:r:Iron uptake and transport", "R-SSC-195253:r:Degradation of beta-catenin by the destruction complex", "R-CFA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-5696400:r:Dual Incision in GG-NER", "R-GGA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-BTA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-GGA-6783310:r:Fanconi Anemia Pathway", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DME-5357905:r:Regulation of TNFR1 signaling", "R-CFA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-RNO-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SSC-202424:r:Downstream TCR signaling", "R-RNO-9770562:r:mRNA Polyadenylation", "R-SSC-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-GGA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-CFA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SSC-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CEL-9020702:r:Interleukin-1 signaling", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CFA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-69231:r:Cyclin D associated events in G1", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-69231:r:Cyclin D associated events in G1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5656121:r:Translesion synthesis by POLI", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-CFA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-9020702:r:Interleukin-1 signaling", "R-SSC-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-GGA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-3322077:r:Glycogen synthesis", "R-GGA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 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"R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-CFA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-DDI-5689877:r:Josephin domain DUBs", "R-RNO-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5689901:r:Metalloprotease DUBs", "R-SSC-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-DME-382556:r:ABC-family proteins mediated transport", "R-GGA-4641258:r:Degradation of DVL", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-9770562:r:mRNA Polyadenylation", "R-SSC-8951664:r:Neddylation", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SSC-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-CFA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-2672351:r:Stimuli-sensing channels", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-BTA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-DME-110312:r:Translesion synthesis by REV1", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-CFA-110312:r:Translesion synthesis by REV1", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-CFA-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-RNO-8948747:r:Regulation of PTEN localization", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-6807004:r:Negative regulation of MET activity", "R-BTA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DME-9033241:r:Peroxisomal protein import", "R-SSC-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-538864:r:Degradation of CRY", "R-GGA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-GGA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-GGA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-CEL-68949:r:Orc1 removal from chromatin", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-4608870:r:Asymmetric localization of PCP proteins", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-8951664:r:Neddylation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69231:r:Cyclin D associated events in G1", "R-CEL-5689877:r:Josephin domain DUBs", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CFA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-68949:r:Orc1 removal from chromatin", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-110320:r:Translesion Synthesis by POLH", "R-SSC-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-182971:r:EGFR downregulation", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-GGA-209560:r:NF-kB is activated and signals survival", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense", "R-SSC-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-DME-4641257:r:Degradation of AXIN", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-RNO-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-SSC-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-909733:r:Interferon alpha/beta signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-GGA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-5689877:r:Josephin domain DUBs", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-GGA-6807004:r:Negative regulation of MET activity", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-5655862:r:Translesion synthesis by POLK", "R-CFA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-DDI-917937:r:Iron uptake and transport", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-69231:r:Cyclin D associated events in G1", "R-SSC-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-GGA-5689880:r:Ub-specific processing proteases", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-BTA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-RNO-9020702:r:Interleukin-1 signaling", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-SSC-8948747:r:Regulation of PTEN localization", "R-CFA-917937:r:Iron uptake and transport", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SSC-4641257:r:Degradation of AXIN", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-GGA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-5689603:r:UCH proteinases", "R-GGA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CFA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-GGA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-BTA-9648002:r:RAS processing", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-SSC-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-SPO-5689603:r:UCH proteinases", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SSC-5654727:r:Negative regulation of FGFR2 signaling", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-SSC-9646399:r:Aggrephagy", "R-GGA-351465:r:Fanconi Anemia Pathway in DNA repair", "R-SSC-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5689901:r:Metalloprotease DUBs", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-9648002:r:RAS processing", "R-SSC-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-192823:r:Viral mRNA Translation", "R-CEL-9646399:r:Aggrephagy", "R-CFA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-GGA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9636383:r:Prevention of phagosomal-lysosomal fusion", "R-GGA-353303:r:Nucleotide Excision Repair", "R-CFA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-GGA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SSC-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DME-216167:r:Nuclear CI is degraded", "R-SSC-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-CFA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-DDI-9861718:r:Regulation of pyruvate metabolism", "R-GGA-6804757:r:Regulation of TP53 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"R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CFA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-RNO-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-CFA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5689603:r:UCH proteinases", "R-HSA-5654733:r:Negative regulation of FGFR4 signaling", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-8951664:r:Neddylation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-DME-4641258:r:Degradation of DVL", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype 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"R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-8866427:r:VLDLR internalisation and degradation", "R-GGA-182971:r:EGFR downregulation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-HSA-5675221:r:Negative regulation of MAPK pathway", "R-GGA-5689901:r:Metalloprotease DUBs", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9646399:r:Aggrephagy", "R-SSC-8948751:r:Regulation of PTEN stability and activity", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-5654733:r:Negative regulation of FGFR4 signaling", "R-SSC-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-GGA-5675221:r:Negative regulation of MAPK pathway", "R-DME-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-69481:r:G2/M Checkpoints", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DDI-5689901:r:Metalloprotease DUBs", "R-BTA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-GGA-1227892:r:TRAF6 mediated NF-kB activation", "R-GGA-9766229:r:Degradation of CDH1", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CFA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-CFA-5654733:r:Negative regulation of FGFR4 signaling", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CFA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-4641258:r:Degradation of DVL", "R-GGA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-GGA-9646399:r:Aggrephagy", "R-RNO-5632684:r:Hedgehog 'on' state", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-CFA-9770562:r:mRNA Polyadenylation", "R-CFA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-1227882:r:TRAF mediated activation of IRF", "R-DDI-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-GGA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-SSC-5358346:r:Hedgehog ligand biogenesis", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-9706369:r:Negative regulation of FLT3", "R-MMU-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-9833482:r:PKR-mediated signaling", "R-CFA-68867:r:Assembly of the pre-replicative complex", "R-BTA-187577:r:SCF(Skp2)-mediated 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"R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-9706369:r:Negative regulation of FLT3", "R-DDI-901032:r:ER Quality Control Compartment (ERQC)", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-GGA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-SSC-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-CFA-5685942:r:HDR through Homologous Recombination (HRR)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin 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"R-DME-8866427:r:VLDLR internalisation and degradation", "R-CFA-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-BTA-2672351:r:Stimuli-sensing channels", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5689603:r:UCH proteinases", "R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-CFA-4608870:r:Asymmetric localization of PCP proteins", "R-GGA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9013973:r:TICAM1-dependent activation of IRF3/IRF7", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CFA-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-5632684:r:Hedgehog 'on' state", "R-CFA-209543:r:p75NTR recruits signalling complexes", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-SSC-2871837:r:FCERI mediated NF-kB activation", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-GGA-2672351:r:Stimuli-sensing channels", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-SSC-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-182971:r:EGFR downregulation", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-5689603:r:UCH proteinases", "R-GGA-937041:r:IKK complex recruitment mediated by RIP1", "R-SSC-937039:r:IRAK1 recruits IKK complex", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-5655862:r:Translesion synthesis by POLK", "R-CFA-2672351:r:Stimuli-sensing channels", "R-SSC-69231:r:Cyclin D associated events in G1", "R-CFA-69481:r:G2/M Checkpoints", "R-CFA-8939902:r:Regulation of RUNX2 expression and activity", "R-RNO-5689901:r:Metalloprotease DUBs", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-SSC-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-CFA-8866427:r:VLDLR internalisation and degradation", "R-DME-2467813:r:Separation of Sister Chromatids", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-936964:r:Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)", "R-BTA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-110312:r:Translesion synthesis by REV1", "R-BTA-5689901:r:Metalloprotease DUBs", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-4641258:r:Degradation of DVL", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-CEL-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-CEL-9648002:r:RAS processing", "R-BTA-5675221:r:Negative regulation of MAPK pathway", "R-SCE-8951664:r:Neddylation", "R-SSC-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CFA-4641263:r:Regulation of FZD by ubiquitination", "R-GGA-209543:r:p75NTR recruits signalling complexes", "R-GGA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-182971:r:EGFR downregulation", "R-CFA-909733:r:Interferon alpha/beta signaling", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-SSC-5689896:r:Ovarian tumor domain proteases", "R-SSC-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-SSC-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-GGA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-937039:r:IRAK1 recruits IKK complex", "R-RNO-4641257:r:Degradation of AXIN", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-5689603:r:UCH proteinases", "R-SSC-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689877:r:Josephin domain DUBs", "R-SSC-9020702:r:Interleukin-1 signaling", "R-GGA-9033241:r:Peroxisomal protein import", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-RNO-9664873:r:Pexophagy", "R-CFA-9033241:r:Peroxisomal protein import", "R-CFA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SSC-9708530:r:Regulation of BACH1 activity", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-CFA-5696400:r:Dual Incision in GG-NER", "R-BTA-1295596:r:Spry regulation of FGF signaling", "R-CEL-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-CFA-5689877:r:Josephin domain DUBs", "R-CFA-9706369:r:Negative regulation of FLT3", "R-BTA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-SSC-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-8875360:r:InlB-mediated entry of Listeria monocytogenes into host cell", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-5654726:r:Negative regulation of FGFR1 signaling", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-9664873:r:Pexophagy", "R-CEL-912631:r:Regulation of signaling by CBL", "R-DDI-9646399:r:Aggrephagy", "R-SSC-5654732:r:Negative regulation of FGFR3 signaling", "R-MMU-69541:r:Stabilization of p53", "R-DDI-5632684:r:Hedgehog 'on' state", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-SSC-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-4641257:r:Degradation of AXIN", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-GGA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-CFA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-GGA-5696400:r:Dual Incision in GG-NER", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9694493:r:Maturation of protein E", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-912631:r:Regulation of signaling by CBL", "R-DME-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-GGA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CFA-9646399:r:Aggrephagy", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-BTA-6783310:r:Fanconi Anemia Pathway", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-SSC-72689:r:Formation of a pool of free 40S subunits", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-DDI-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-GGA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-110320:r:Translesion Synthesis by POLH", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-GGA-573298:r:NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation", "R-CFA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-SSC-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-CEL-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-GGA-69541:r:Stabilization of p53", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-CFA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-5689603:r:UCH proteinases", "R-GGA-353299:r:RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-SSC-2672351:r:Stimuli-sensing channels", "R-SSC-6804757:r:Regulation of TP53 Degradation", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-GGA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-9664873:r:Pexophagy", "R-SSC-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-CEL-5655862:r:Translesion synthesis by POLK", "R-GGA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CFA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-CFA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-5689880:r:Ub-specific processing proteases", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5357905:r:Regulation of TNFR1 signaling", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-6804757:r:Regulation of TP53 Degradation", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-912631:r:Regulation of signaling by CBL", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DME-5654727:r:Negative regulation of FGFR2 signaling", "R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-GGA-437980:r:Activated TAK1 mediates p38 MAP kinase phosphorylation", "R-DME-432524:r:Degradation of PER", "R-CFA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-SSC-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SSC-9932298:r:Degradation of CRY and PER proteins", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-5689901:r:Metalloprotease DUBs", "R-SSC-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-SSC-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-DME-9770562:r:mRNA Polyadenylation", "R-GGA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-CFA-6804760:r:Regulation of TP53 Activity through Methylation", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-DME-8863795:r:Downregulation of ERBB2 signaling", "R-GGA-1295596:r:Spry regulation of FGF signaling", "R-GGA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SSC-8941858:r:Regulation of RUNX3 expression and activity", "R-CFA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-912631:r:Regulation of signaling by CBL", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-CFA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-CFA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-BTA-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-9648002:r:RAS processing", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5656121:r:Translesion synthesis by POLI", "R-RNO-5654733:r:Negative regulation of FGFR4 signaling", "R-CFA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-GGA-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-CFA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-GGA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SSC-4641263:r:Regulation of FZD by ubiquitination", "R-SSC-5655862:r:Translesion synthesis by POLK", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-BTA-9824878:r:Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-BTA-9033241:r:Peroxisomal protein import", "R-CEL-917729:r:Endosomal Sorting Complex Required For Transport (ESCRT)", "R-DME-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-CFA-9664873:r:Pexophagy", "R-GGA-382556:r:ABC-family proteins mediated transport", "R-BTA-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-5675482:r:Regulation of necroptotic cell death", "R-DME-8948747:r:Regulation of PTEN localization", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-110312:r:Translesion synthesis by REV1", "R-BTA-901032:r:ER Quality Control Compartment (ERQC)", "R-CFA-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-BTA-9708530:r:Regulation of BACH1 activity", "R-CEL-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-CFA-6782135:r:Dual incision in TC-NER", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-CFA-4641257:r:Degradation of AXIN", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SSC-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-SSC-68949:r:Orc1 removal from chromatin", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-GGA-68867:r:Assembly of the pre-replicative complex", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-BTA-8948747:r:Regulation of PTEN localization", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-BTA-9646399:r:Aggrephagy", "R-CFA-1253288:r:Downregulation of ERBB4 signaling", "R-BTA-72649:r:Translation initiation complex formation", "R-CFA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DDI-6782135:r:Dual incision in TC-NER", "R-CFA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-8948747:r:Regulation of PTEN localization", "R-MMU-110312:r:Translesion synthesis by REV1", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-BTA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-GGA-5655862:r:Translesion synthesis by POLK", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CFA-5689880:r:Ub-specific processing proteases", "R-BTA-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-SSC-9706369:r:Negative regulation of FLT3", "R-GGA-8939902:r:Regulation of RUNX2 expression and activity", "R-GGA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-DME-5689603:r:UCH proteinases", "R-MMU-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SSC-6804760:r:Regulation of TP53 Activity through Methylation", "R-CFA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SSC-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-GGA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-GGA-4641263:r:Regulation of FZD by ubiquitination", "R-CEL-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-GGA-5654732:r:Negative regulation of FGFR3 signaling", "R-HSA-9706377:r:FLT3 signaling by CBL mutants", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9766229:r:Degradation of CDH1", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-SSC-5632684:r:Hedgehog 'on' state", "R-GGA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-SSC-182971:r:EGFR downregulation", "R-HSA-9637628:r:Modulation by Mtb of host immune system", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "type": "Family"}, "IPR050159": {"description": "Kazal-type Serine Protease Inhibitor", "go_ids": [], "go_terms": [], "name": "Kazal-type_SerProtInhib", "pathway_ids": ["R-RNO-6809371", "R-MMU-6809371", "R-HSA-6809371", "R-HSA-9725554", "R-BTA-6809371"], "pathways": ["R-RNO-6809371:r:Formation of the cornified envelope", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-BTA-6809371:r:Formation of the cornified envelope"], "type": "Family"}, "IPR050160": {"description": "Major Histocompatibility Complex/Immunoglobulin", "go_ids": [], "go_terms": [], "name": "MHC/Immunoglobulin", "pathway_ids": ["R-SSC-2730905", "R-HSA-6798695", "R-SSC-2168880", "R-HSA-173623", "R-SSC-5690714", "R-GGA-198933", "R-HSA-2871796", "R-HSA-2168880", "R-RNO-202433", "R-BTA-6798695", "R-HSA-2029481", "R-SSC-202733", "R-MMU-202430", "R-MMU-2871796", "R-HSA-202427", "R-SSC-2132295", "R-RNO-202427", "R-SSC-202433", "R-MMU-202733", "R-RNO-202424", "R-SSC-173623", "R-MMU-2029485", "R-HSA-166663", "R-SSC-2454202", "R-HSA-202430", "R-MMU-2168880", "R-BTA-198933", "R-HSA-983695", "R-RNO-198933", "R-RNO-1236977", "R-HSA-2424491", "R-SSC-1236977", "R-HSA-2172127", "R-MMU-1236977", "R-HSA-2029482", "R-GGA-1236974", "R-SSC-2029485", "R-MMU-5690714", "R-GGA-2132286", "R-GGA-6798695", "R-HSA-164940", "R-MMU-198933", "R-MMU-2871837", "R-SSC-983170", "R-MMU-983170", "R-SSC-389948", "R-HSA-198933", "R-MMU-2730905", "R-MMU-6798695", "R-MMU-202427", "R-BTA-1236974", "R-HSA-1236974", "R-HSA-9664323", "R-BTA-2424491", "R-BTA-1236977", "R-RNO-6798695", "R-GGA-2132263", "R-SSC-1236974", "R-HSA-2132295", "R-RNO-2172127", "R-RNO-983170", "R-SSC-6798695", "R-SSC-202427", "R-HSA-9705671", "R-HSA-202433", "R-HSA-977225", "R-SSC-198933", "R-HSA-2029485", "R-RNO-1236974", "R-MMU-2172127", "R-MMU-173623", "R-HSA-2871837", "R-HSA-2454202", "R-DRE-2132295", "R-HSA-977606", "R-SSC-2871809", "R-MMU-2132295", "R-HSA-2730905", "R-SSC-2029482", "R-GGA-983170", "R-GGA-1236977", "R-SSC-2029481", "R-MMU-202424", "R-SSC-2871796", "R-MMU-389948", "R-MMU-202433", "R-RNO-2132295", "R-MMU-977606", "R-HSA-2871809", "R-SSC-2424491", "R-HSA-5690714", "R-HSA-9679191", "R-MMU-983695", "R-MMU-2454202", "R-HSA-1236977", "R-MMU-2029482", "R-SSC-2871837", "R-MMU-2029481", "R-BTA-983170", "R-SSC-202424", "R-SSC-977606", "R-HSA-983170", "R-SSC-983695", "R-SSC-202430", "R-RNO-2424491", "R-HSA-202424", "R-MMU-2871809", "R-HSA-877300", "R-MMU-1236974", "R-RNO-389948", "R-MMU-2424491", "R-RNO-202430", "R-HSA-9664422", "R-HSA-389948", "R-HSA-202733", "R-HSA-9637628"], "pathways": ["R-SSC-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-2168880:r:Scavenging of heme from plasma", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-SSC-5690714:r:CD22 mediated BCR regulation", "R-GGA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-RNO-202433:r:Generation of second messenger molecules", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-2029481:r:FCGR activation", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-2132295:r:MHC class II antigen presentation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-SSC-202433:r:Generation of second messenger molecules", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-RNO-202424:r:Downstream TCR signaling", "R-SSC-173623:r:Classical antibody-mediated complement activation", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-166663:r:Initial triggering of complement", "R-SSC-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-2424491:r:DAP12 signaling", "R-SSC-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-2172127:r:DAP12 interactions", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-1236974:r:ER-Phagosome pathway", "R-SSC-2029485:r:Role of phospholipids in phagocytosis", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-GGA-2132286:r:Classical antibody-mediated complement activation", "R-GGA-6798695:r:Neutrophil degranulation", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-SSC-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SSC-389948:r:Co-inhibition by PD-1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-6798695:r:Neutrophil 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"R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-1236974:r:ER-Phagosome pathway", "R-MMU-2172127:r:DAP12 interactions", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-DRE-2132295:r:MHC class II antigen presentation", "R-HSA-977606:r:Regulation of Complement cascade", "R-SSC-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-SSC-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-GGA-1236977:r:Endosomal/Vacuolar pathway", "R-SSC-2029481:r:FCGR activation", "R-MMU-202424:r:Downstream TCR signaling", "R-SSC-2871796:r:FCERI mediated MAPK activation", "R-MMU-389948:r:Co-inhibition by PD-1", "R-MMU-202433:r:Generation of 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B Cell Receptor (BCR) leading to generation of second messengers", "R-SSC-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-877300:r:Interferon gamma signaling", "R-MMU-1236974:r:ER-Phagosome pathway", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-2424491:r:DAP12 signaling", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9637628:r:Modulation by Mtb of host immune system"], "type": "Family"}, "IPR050161": {"description": "Siroheme/cobalamin biosynthesis enzyme", "go_ids": [], "go_terms": [], "name": "Siro_Cobalamin_biosynth", "pathway_ids": ["PWY-5196", "PWY-5194", "PWY-7377"], "pathways": ["PWY-5196:t:factor 430 biosynthesis", "PWY-5194:t:siroheme biosynthesis", "PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Family"}, "IPR050162": {"description": "Methionine Sulfoxide Reductase A", "go_ids": [], "go_terms": [], "name": "MsrA_MetSO_reductase", "pathway_ids": ["R-MMU-5676934", "R-BTA-5676934", "R-HSA-5676934", "R-RNO-5676934"], "pathways": ["R-MMU-5676934:r:Protein repair", "R-BTA-5676934:r:Protein repair", "R-HSA-5676934:r:Protein repair", "R-RNO-5676934:r:Protein repair"], "type": "Family"}, "IPR050163": {"description": "Apolipoprotein A1/A4/E", "go_ids": [], "go_terms": [], "name": "Apolipoprotein_A1/A4/E", "pathway_ids": ["R-HSA-1989781", "R-MMU-8963888", "R-HSA-9920588", "R-HSA-8963889", "R-GGA-3000471", "R-GGA-975634", "R-HSA-2168880", "R-BTA-8963896", "R-HSA-8963901", "R-RNO-8964026", "R-HSA-8864260", "R-BTA-8963888", "R-HSA-1369062", "R-MMU-8957275", "R-RNO-3000471", "R-MMU-975634", "R-BTA-8957275", "R-MMU-9707616", "R-MMU-381426", "R-GGA-8964011", "R-GGA-8957275", "R-MMU-8964011", "R-MMU-8964058", "R-MMU-2168880", "R-HSA-381426", "R-DRE-8963896", "R-DRE-3000480", "R-HSA-9918432", "R-RNO-2168880", "R-BTA-8963901", "R-DRE-8964011", "R-BTA-9707616", "R-BTA-975634", "R-RNO-8964011", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-DRE-8964058", "R-RNO-8963896", "R-GGA-8963896", "R-DRE-381426", "R-DRE-3000471", "R-RNO-1369062", "R-GGA-8963888", "R-MMU-114608", "R-HSA-8964011", "R-DRE-114608", "R-RNO-8963901", "R-HSA-3000480", "R-HSA-1251985", "R-HSA-977225", "R-MMU-1369062", "R-MMU-3000480", "R-RNO-114608", "R-HSA-114608", "R-BTA-114608", "R-HSA-3000471", "R-RNO-8957275", "R-BTA-381426", "R-RNO-975634", "R-RNO-9707616", "R-HSA-9029569", "R-GGA-381426", "R-RNO-8964058", "R-GGA-9707616", "R-HSA-9918481", "R-DRE-8957275", "R-BTA-8964058", "R-BTA-3000471", "R-GGA-8964058", "R-GGA-1369062", "R-HSA-8963896", "R-MMU-3000471", "R-HSA-8964058", "R-HSA-8964026", "R-GGA-2168880", "R-MMU-8964026", "R-HSA-9707616", "R-GGA-114608", "R-HSA-8963888", "R-HSA-5682113", 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"R-RNO-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8964058:r:HDL remodeling", "R-GGA-9707616:r:Heme signaling", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-BTA-8964058:r:HDL remodeling", "R-BTA-3000471:r:Scavenging by Class B Receptors", "R-GGA-8964058:r:HDL remodeling", "R-GGA-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-8963896:r:HDL assembly", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964058:r:HDL remodeling", "R-HSA-8964026:r:Chylomicron clearance", "R-GGA-2168880:r:Scavenging of heme from plasma", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-GGA-114608:r:Platelet degranulation", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-5682113:r:Defective ABCA1 causes TGD", "R-MMU-8963896:r:HDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-BTA-8964011:r:HDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Family"}, "IPR050164": {"description": "Ubiquitin carboxyl-terminal hydrolases", "go_ids": [], "go_terms": [], "name": "Peptidase_C19", "pathway_ids": ["R-MMU-2173795", "R-RNO-6781823", "R-CEL-8948747", "R-BTA-5689880", "R-SPO-5656169", "R-HSA-5689880", "R-DME-6781823", "R-RNO-110314", "R-MMU-8866652", "R-HSA-9013424", "R-SPO-9664873", "R-HSA-6781823", "R-MMU-110314", "R-MMU-5689880", "R-MMU-445989", "R-MMU-9013420", "R-HSA-8866652", "R-HSA-6804757", "R-SCE-9664873", "R-DME-8948747", "R-DME-9664873", "R-RNO-5656169", "R-XTR-5689880", "R-DME-6782135", "R-RNO-6782210", "R-DRE-8948751", "R-DDI-8948751", "R-MMU-8948747", "R-HSA-9758274", "R-MMU-201681", "R-DME-5689880", "R-CEL-6782210", "R-HSA-6783310", "R-RNO-5689880", "R-CEL-6781823", "R-DME-9648002", "R-RNO-6804757", "R-CEL-6782135", "R-MMU-6782210", "R-HSA-9648002", "R-DDI-8866652", "R-SCE-6782135", "R-HSA-9664873", "R-HSA-110314", "R-DME-6804757", "R-HSA-201681", "R-HSA-445989", "R-HSA-6781827", "R-MMU-6782135", "R-MMU-9648002", "R-HSA-977225", "R-RNO-8866652", "R-DME-9013424", "R-HSA-1169408", "R-DME-8866652", "R-CFA-5689880", "R-DRE-5696395", "R-MMU-9664873", "R-MMU-6781823", "R-HSA-2173795", "R-HSA-6782210", "R-HSA-912694", "R-SCE-6782210", "R-HSA-5656169", "R-DDI-5689880", "R-RNO-8948747", "R-DRE-5689880", "R-HSA-9013420", "R-RNO-9664873", "R-HSA-8948747", "R-DME-9033241", "R-RNO-6782135", "R-MMU-6804757", "R-MMU-5656169", "R-MMU-9013424", "R-DME-9758274", "R-HSA-6782135", "R-DME-2173795", "R-MMU-9033241", "R-MMU-1169408", "R-MMU-6783310", "R-CEL-5689880", "R-DME-445989", "R-CEL-1169408", "R-SPO-6782210", "R-DME-6782210", "R-SPO-6782135", "R-MMU-9758274", "R-MMU-912694", "R-HSA-9033241", "R-RNO-6783310", "R-DME-9013420"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-8948747:r:Regulation of PTEN localization", "R-BTA-5689880:r:Ub-specific processing proteases", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-9013424:r:RHOV GTPase cycle", "R-SPO-9664873:r:Pexophagy", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-SCE-9664873:r:Pexophagy", "R-DME-8948747:r:Regulation of PTEN localization", "R-DME-9664873:r:Pexophagy", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-XTR-5689880:r:Ub-specific processing proteases", "R-DME-6782135:r:Dual incision in TC-NER", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DRE-8948751:r:Regulation of PTEN stability and activity", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-MMU-8948747:r:Regulation of PTEN localization", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-9648002:r:RAS processing", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-CEL-6782135:r:Dual incision in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-9648002:r:RAS processing", "R-DDI-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-9664873:r:Pexophagy", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-6804757:r:Regulation of TP53 Degradation", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-9648002:r:RAS processing", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-DME-9013424:r:RHOV GTPase cycle", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-CFA-5689880:r:Ub-specific processing proteases", "R-DRE-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-9664873:r:Pexophagy", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DDI-5689880:r:Ub-specific processing proteases", "R-RNO-8948747:r:Regulation of PTEN localization", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-9664873:r:Pexophagy", "R-HSA-8948747:r:Regulation of PTEN localization", "R-DME-9033241:r:Peroxisomal protein import", "R-RNO-6782135:r:Dual incision in TC-NER", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-CEL-5689880:r:Ub-specific processing proteases", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-6783310:r:Fanconi Anemia Pathway", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Family"}, "IPR050165": {"description": "Dihydroxy-acid dehydratase IlvD/Edd", "go_ids": [], "go_terms": [], "name": "DHAD_IlvD/Edd", "pathway_ids": ["PWY-7111", "PWY-5101", "PWY-5103", "PWY-5104"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-5103:t:L-isoleucine biosynthesis III", "PWY-5104:t:L-isoleucine biosynthesis IV"], "type": "Family"}, "IPR050166": {"description": "ABC transporter ATP-binding protein", "go_ids": [], "go_terms": [], "name": "ABC_transporter_ATP-bind", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050167": {"description": "Serine/threonine-protein kinase", "go_ids": [], "go_terms": [], "name": "Ser_Thr_protein_kinase", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-DDI-3295583", "R-CEL-5675221", "R-HSA-6802952", "R-MMU-5673000", "R-CEL-5673000", "R-CEL-5674135", "R-DDI-5675221", "R-DDI-5675482", "R-HSA-5673000", "R-DDI-5213460", "R-DDI-5674135", "R-HSA-9649948", "R-HSA-6802946", "R-DDI-5673000", "R-HSA-6802955", "R-MMU-5675221", "R-HSA-9656223", "R-HSA-5675221"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DDI-3295583:r:TRP channels", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-5673000:r:RAF activation", "R-CEL-5673000:r:RAF activation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-HSA-5673000:r:RAF activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DDI-5673000:r:RAF activation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR050168": {"description": "AAA ATPase domain-containing protein", "go_ids": [], "go_terms": [], "name": "AAA_ATPase_domain", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-XTR-532668", "R-HSA-5689896", "R-HSA-8951664", "R-CEL-6798695", "R-MMU-110320", "R-DME-8951664", "R-DRE-8951664", "R-HSA-9918487", "R-RNO-382556", "R-XTR-5689896", "R-MMU-5689896", "R-CEL-532668", "R-CEL-5358346", "R-CEL-5689877", "R-DME-5689896", "R-CEL-9013407", "R-MMU-8951664", "R-RNO-9033241", "R-MMU-5689877", "R-CEL-382556", "R-RNO-5689877", "R-CEL-110320", "R-HSA-9678110", "R-XTR-9931269", "R-MMU-3371511", "R-DRE-6798695", "R-DRE-9013407", "R-XTR-9013407", "R-HSA-532668", "R-HSA-9931269", "R-MMU-9013407", "R-DRE-9931269", "R-DME-110320", "R-RNO-9013407", "R-HSA-5678895", "R-SCE-9755511", "R-RNO-3371511", "R-RNO-9931269", "R-HSA-9694614", "R-HSA-9755511", "R-XTR-6798695", "R-DME-9755511", "R-HSA-8866654", "R-DRE-9755511", "R-SCE-8951664", "R-RNO-532668", "R-RNO-8951664", "R-MMU-9931269", "R-MMU-6798695", "R-SPO-8951664", "R-RNO-5689896", "R-RNO-5358346", "R-HSA-5358346", "R-DME-5358346", "R-RNO-6798695", "R-HSA-9013407", "R-HSA-3371511", "R-SCE-8876725", "R-HSA-8876725", "R-DRE-5689877", "R-SCE-5689896", "R-DRE-382556", "R-SPO-6798695", "R-XTR-8876725", "R-XTR-382556", "R-DME-382556", "R-SCE-6798695", "R-MMU-9755511", "R-DRE-532668", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-DRE-5689896", "R-MMU-532668", "R-SPO-5689896", "R-HSA-5689877", "R-DME-9013407", "R-MMU-382556", "R-DRE-5358346", "R-DRE-3371511", "R-CEL-9755511", "R-DME-6798695", "R-RNO-9755511", "R-HSA-382556", "R-CEL-9931269", "R-MMU-9033241", "R-RNO-110320", "R-XTR-8951664", "R-DME-3371511", "R-DME-532668", "R-SPO-8876725", "R-XTR-110320", "R-SPO-9755511", "R-MMU-8876725", "R-XTR-5358346", "R-DRE-110320", "R-SPO-3371511", "R-DRE-8876725", "R-XTR-9755511", "R-SPO-110320", "R-SCE-3371511", "R-HSA-110320", "R-HSA-9033241", "R-CEL-8951664"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9646399:r:Aggrephagy", "R-XTR-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-8951664:r:Neddylation", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-DME-8951664:r:Neddylation", 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GG-NER", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-XTR-5689880:r:Ub-specific processing proteases", "R-MMU-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-GGA-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689603:r:UCH proteinases", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-DME-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR050186": {"description": "Triose Phosphate/Phosphate Translocator", "go_ids": [], "go_terms": [], "name": "TPT_transporter", "pathway_ids": ["R-SPO-727802", "R-CEL-2022928", "R-HSA-5579020", "R-BTA-727802", "R-DME-727802", "R-HSA-727802", "R-SPO-6787639", "R-DDI-727802", "R-CEL-2022854", "R-MMU-2022854", "R-HSA-5619078", "R-MMU-727802", "R-MMU-173599", "R-HSA-6787639", "R-BTA-173599", "R-DME-173599", "R-DME-6787639", "R-DDI-6787639", "R-DME-2022928", "R-HSA-2022854", "R-BTA-6787639", "R-CEL-173599", "R-CEL-727802", "R-MMU-2022928", "R-HSA-2022928", "R-DME-2022854", "R-MMU-6787639", "R-HSA-173599", "R-CEL-6787639"], "pathways": ["R-SPO-727802:r:Transport of nucleotide sugars", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-HSA-5579020:r:Defective SLC35D1 causes SCHBCKD", "R-BTA-727802:r:Transport of nucleotide sugars", "R-DME-727802:r:Transport of nucleotide sugars", "R-HSA-727802:r:Transport of nucleotide sugars", "R-SPO-6787639:r:GDP-fucose biosynthesis", "R-DDI-727802:r:Transport of nucleotide sugars", "R-CEL-2022854:r:Keratan sulfate biosynthesis", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-HSA-5619078:r:Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)", "R-MMU-727802:r:Transport of nucleotide sugars", "R-MMU-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-HSA-6787639:r:GDP-fucose biosynthesis", "R-BTA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DME-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-DME-6787639:r:GDP-fucose biosynthesis", "R-DDI-6787639:r:GDP-fucose biosynthesis", "R-DME-2022928:r:HS-GAG biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-BTA-6787639:r:GDP-fucose biosynthesis", "R-CEL-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-CEL-727802:r:Transport of nucleotide sugars", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-DME-2022854:r:Keratan sulfate biosynthesis", "R-MMU-6787639:r:GDP-fucose biosynthesis", "R-HSA-173599:r:Formation of the active cofactor, UDP-glucuronate", "R-CEL-6787639:r:GDP-fucose biosynthesis"], "type": "Family"}, "IPR050187": {"description": "Lipid Phosphate Formation and Regulation", "go_ids": [], "go_terms": [], "name": "Lipid_Phosphate_FormReg", "pathway_ids": ["PWY-8394", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-7769", "PWY-7077", "PWY-7740", "PWY-6626", "PWY-8129", "PWY-8392", "PWY-7948", "PWY-7321", "PWY-8393", "PWY-8367", "PWY-8324", "PWY-6955", "PWY-6682", "PWY-7975", "PWY-7886", "PWY-8402", "R-DDI-5218921", "R-HSA-6802952", "R-DDI-1660661", "R-HSA-9833482", "R-DDI-9009391", "R-SCE-1660661", "R-SCE-9833482", "R-DDI-1483206", "R-MMU-9009391", "R-RNO-9009391", "R-CEL-9840309", "R-SPO-5218921", "R-MMU-9833482", "R-MMU-1483206", "R-SPO-9009391", "R-SPO-390471", "R-RNO-390471", "R-HSA-1483206", "R-SPO-1483206", "R-CEL-1660661", "R-SCE-390471", "R-MMU-5218921", "R-CEL-1483206", "R-DDI-9833482", "R-HSA-390471", "R-DDI-390471", "R-MMU-390471", "R-SCE-9009391", "R-CEL-9833482", "R-HSA-1660661", "R-HSA-5218921", "R-RNO-5218921", "R-HSA-9009391", "R-DRE-1483206", "R-HSA-9840309", "R-SCE-5218921", "R-SPO-9833482", "R-CEL-5218921", "R-SCE-1483206", "R-MMU-9840309", "R-CEL-390471", "R-RNO-1660661", "R-CEL-9009391", "R-SPO-1660661", "R-RNO-9833482", "R-MMU-1660661"], "pathways": ["PWY-8394:t:ribitol degradation II", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6369:t:inositol diphosphates biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7077:t:N-acetyl-D-galactosamine degradation", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-8129:t:cell-surface glycoconjugate-linked phosphonate biosynthesis", "PWY-8392:t:D-arabinitol degradation II", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-8393:t:xylitol degradation II", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8324:t:D-tagatose degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7975:t:adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II", "PWY-7886:t:cell-surface glycoconjugate-linked phosphocholine biosynthesis", "PWY-8402:t:N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation", "R-DDI-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-9833482:r:PKR-mediated signaling", "R-DDI-9009391:r:Extra-nuclear estrogen signaling", "R-SCE-1660661:r:Sphingolipid de novo biosynthesis", "R-SCE-9833482:r:PKR-mediated signaling", "R-DDI-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-9840309:r:Glycosphingolipid biosynthesis", "R-SPO-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-1483206:r:Glycerophospholipid biosynthesis", "R-SPO-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-1483206:r:Glycerophospholipid biosynthesis", "R-SPO-1483206:r:Glycerophospholipid biosynthesis", "R-CEL-1660661:r:Sphingolipid de novo biosynthesis", "R-SCE-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-1483206:r:Glycerophospholipid biosynthesis", "R-DDI-9833482:r:PKR-mediated signaling", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-DDI-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SCE-9009391:r:Extra-nuclear estrogen signaling", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-1483206:r:Glycerophospholipid biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-SCE-5218921:r:VEGFR2 mediated cell proliferation", "R-SPO-9833482:r:PKR-mediated signaling", "R-CEL-5218921:r:VEGFR2 mediated cell proliferation", "R-SCE-1483206:r:Glycerophospholipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-CEL-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-CEL-9009391:r:Extra-nuclear estrogen signaling", "R-SPO-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-9833482:r:PKR-mediated signaling", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR050188": {"description": "RluA Pseudouridine Synthase", "go_ids": [], "go_terms": [], "name": "RluA_PseudoU_synthase", "pathway_ids": ["R-HSA-9937008", "R-HSA-6793080"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Family"}, "IPR050189": {"description": "Major Facilitator Superfamily Efflux Transporters", "go_ids": [], "go_terms": [], "name": "MFS_Efflux_Transporters", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050190": {"description": "UPF0213 domain-containing protein", "go_ids": [], "go_terms": [], "name": "UPF0213_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050191": {"description": "ATP-dependent DNA ligase", "go_ids": [], "go_terms": [], "name": "ATP-dep_DNA_ligase", "pathway_ids": ["R-HSA-9825895", "R-MMU-5649702", "R-HSA-174414", "R-HSA-9913635", "R-HSA-5696397", "R-HSA-5358606", "R-SCE-5358606", "R-SCE-110362", "R-MMU-110381", "R-RNO-110362", "R-HSA-5649702", "R-DDI-110381", "R-DME-5358565", "R-RNO-69183", "R-MMU-110362", "R-MMU-174414", "R-CEL-69183", "R-SCE-5358565", "R-DME-69183", "R-HSA-6782210", "R-MMU-5685939", "R-CEL-5358565", "R-MMU-5358606", "R-MMU-5358565", "R-DDI-5358565", "R-RNO-6782210", "R-DDI-5358606", "R-DDI-110362", "R-RNO-5358606", "R-RNO-5358565", "R-DME-5651801", "R-SCE-69183", "R-SPO-5358565", "R-MMU-5651801", "R-DDI-69183", "R-SPO-69183", "R-HSA-110362", "R-DME-5358606", "R-CEL-6782210", "R-HSA-5651801", "R-CEL-5358606", "R-HSA-5685939", "R-MMU-69183", "R-DDI-5649702", "R-HSA-162594", "R-HSA-110381", "R-SPO-6782210", "R-HSA-69183", "R-SPO-5358606", "R-HSA-5358565", "R-MMU-6782210", "R-CEL-5651801", "R-DME-6782210", "R-RNO-5651801", "R-RNO-174414", "R-SPO-5651801"], "pathways": ["R-HSA-9825895:r:Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence", "R-MMU-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9913635:r:Strand-asynchronous mitochondrial DNA replication", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SCE-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-SCE-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-RNO-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-HSA-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-DDI-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-DME-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-MMU-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-SCE-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-CEL-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DDI-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-DDI-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-SPO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-HSA-110362:r:POLB-Dependent Long Patch Base Excision Repair", "R-DME-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-CEL-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-DDI-5649702:r:APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-110381:r:Resolution of AP sites via the single-nucleotide replacement pathway", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-SPO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR050192": {"description": "Nickel-responsive transcriptional regulator", "go_ids": [], "go_terms": [], "name": "CopG/NikR_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050193": {"description": "Plant Cytochrome P450 71", "go_ids": [], "go_terms": [], "name": "Cytochrome_P450_71", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050194": {"description": "Glycosyltransferase group 1", "go_ids": [], "go_terms": [], "name": "Glycosyltransferase_grp1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050195": {"description": "Primate lentivirus group Gag polyprotein-like", "go_ids": [], "go_terms": [], "name": "Primate_lentivir_Gag_pol-like", "pathway_ids": ["R-HSA-180910", "R-HSA-164516", "R-HSA-162585", "R-HSA-1169408", "R-HSA-162588", "R-HSA-180689", "R-HSA-164843", "R-HSA-164525", "R-HSA-162594", "R-HSA-162592", "R-HSA-177539", "R-HSA-174490", "R-HSA-175567", "R-HSA-175474", "R-HSA-174495", "R-HSA-173107"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-164516:r:Minus-strand DNA synthesis", "R-HSA-162585:r:Uncoating of the HIV Virion", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-164843:r:2-LTR circle formation", "R-HSA-164525:r:Plus-strand DNA synthesis", "R-HSA-162594:r:Early Phase of HIV Life Cycle", "R-HSA-162592:r:Integration of provirus", "R-HSA-177539:r:Autointegration results in viral DNA circles", "R-HSA-174490:r:Membrane binding and targetting of GAG proteins", "R-HSA-175567:r:Integration of viral DNA into host genomic DNA", "R-HSA-175474:r:Assembly Of The HIV Virion", "R-HSA-174495:r:Synthesis And Processing Of GAG, GAGPOL Polyproteins", "R-HSA-173107:r:Binding and entry of HIV virion"], "type": "Domain"}, "IPR050196": {"description": "Cytochrome P450 Monooxygenases", "go_ids": [], "go_terms": [], "name": "Cytochrome_P450_Monoox", "pathway_ids": ["R-HSA-2142816", "R-HSA-1989781", "R-HSA-2142691", "R-DRE-211976", "R-DME-211976", "R-MMU-211935", "R-DRE-193144", "R-DME-211916", "R-SSC-211976", "R-HSA-211979", "R-RNO-211979", "R-SSC-2142691", "R-DME-196791", "R-DME-2142816", "R-DME-2453902", "R-DME-2142691", "R-RNO-211958", "R-MMU-211958", "R-RNO-193144", "R-MMU-2142816", "R-SSC-193144", "R-RNO-2142816", "R-RNO-211935", "R-DME-193144", "R-DME-211958", "R-MMU-2453902", "R-SSC-211958", "R-RNO-2453902", "R-MMU-211979", "R-SSC-2142816", "R-RNO-2142691", "R-DME-211935", "R-HSA-211958", "R-MMU-211976", "R-SSC-211979", "R-RNO-211976", "R-MMU-2142691", "R-SSC-211935", "R-HSA-5579030", "R-HSA-193144", "R-MMU-193144", "R-HSA-211935", "R-HSA-5579005", "R-DME-211979", "R-HSA-211976", "R-HSA-2453902"], "pathways": ["R-HSA-2142816:r:Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DRE-211976:r:Endogenous sterols", "R-DME-211976:r:Endogenous sterols", "R-MMU-211935:r:Fatty acids", "R-DRE-193144:r:Estrogen biosynthesis", "R-DME-211916:r:Vitamins", "R-SSC-211976:r:Endogenous sterols", "R-HSA-211979:r:Eicosanoids", "R-RNO-211979:r:Eicosanoids", "R-SSC-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DME-196791:r:Vitamin D (calciferol) metabolism", "R-DME-2142816:r:Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DME-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-RNO-211958:r:Miscellaneous substrates", "R-MMU-211958:r:Miscellaneous substrates", "R-RNO-193144:r:Estrogen biosynthesis", "R-MMU-2142816:r:Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "R-SSC-193144:r:Estrogen biosynthesis", "R-RNO-2142816:r:Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "R-RNO-211935:r:Fatty acids", "R-DME-193144:r:Estrogen biosynthesis", "R-DME-211958:r:Miscellaneous substrates", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-SSC-211958:r:Miscellaneous substrates", "R-RNO-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-MMU-211979:r:Eicosanoids", "R-SSC-2142816:r:Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DME-211935:r:Fatty acids", "R-HSA-211958:r:Miscellaneous substrates", "R-MMU-211976:r:Endogenous sterols", "R-SSC-211979:r:Eicosanoids", "R-RNO-211976:r:Endogenous sterols", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SSC-211935:r:Fatty acids", "R-HSA-5579030:r:Defective CYP19A1 causes AEXS", "R-HSA-193144:r:Estrogen biosynthesis", "R-MMU-193144:r:Estrogen biosynthesis", "R-HSA-211935:r:Fatty acids", "R-HSA-5579005:r:Defective CYP4F22 causes ARCI5", "R-DME-211979:r:Eicosanoids", "R-HSA-211976:r:Endogenous sterols", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Family"}, "IPR050197": {"description": "Aldolase class II family, sugar metabolism enzymes", "go_ids": [], "go_terms": [], "name": "Aldolase_class_II_sugar_metab", "pathway_ids": [], "pathways": [], "type": "Family"}, 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"R-RNO-180292", "R-RNO-389356", "R-CEL-2029482", "R-GGA-1433559", "R-MMU-418592", "R-GGA-432142", "R-BTA-1433559", "R-RNO-114604", "R-HSA-418594", "R-DRE-8853659", "R-RNO-5218921", "R-MMU-2871809", "R-BTA-389513", "R-DME-9841922", "R-HSA-9705462", "R-DRE-1295596", "R-MMU-2424491", "R-MMU-8849472", "R-DRE-373753", "R-RNO-186763", "R-MMU-8857538", "R-DRE-3928663"], "pathways": ["R-RNO-418592:r:ADP signalling through P2Y purinoceptor 1", "R-SSC-9766229:r:Degradation of CDH1", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-1227986:r:Signaling by ERBB2", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-912631:r:Regulation of signaling by CBL", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-GGA-354192:r:Integrin signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-912631:r:Regulation of signaling by CBL", "R-MMU-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-3928664:r:Ephrin signaling", "R-CEL-9013407:r:RHOH GTPase cycle", "R-RNO-399954:r:Sema3A PAK dependent Axon repulsion", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-210990:r:PECAM1 interactions", "R-BTA-210990:r:PECAM1 interactions", "R-SSC-912631:r:Regulation of signaling by CBL", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-SSC-8866376:r:Reelin signalling pathway", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-186763:r:Downstream signal transduction", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-9013407:r:RHOH GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-5673000:r:RAF activation", "R-HSA-437239:r:Recycling pathway of L1", "R-HSA-418555:r:G alpha (s) signalling events", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-186763:r:Downstream signal transduction", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-8934593:r:Regulation of RUNX1 Expression and Activity", "R-DRE-5673000:r:RAF activation", "R-CEL-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-389356:r:Co-stimulation by CD28", "R-DRE-1227986:r:Signaling by ERBB2", "R-HSA-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-SSC-375165:r:NCAM 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Sema3A signaling", "R-BTA-180292:r:GAB1 signalosome", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-SSC-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-CEL-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-418885:r:DCC mediated attractive signaling", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-2029481:r:FCGR activation", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-MMU-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-SSC-3928663:r:EPHA-mediated growth cone collapse", "R-DRE-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-9032759:r:NTRK2 activates RAC1", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-375165:r:NCAM signaling for neurite out-growth", "R-RNO-389948:r:Co-inhibition by PD-1", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-BTA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-DRE-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-MMU-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-1433559:r:Regulation of KIT signaling", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-HSA-180292:r:GAB1 signalosome", "R-RNO-5621480:r:Dectin-2 family", "R-CEL-6798695:r:Neutrophil degranulation", "R-GGA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-1227986:r:Signaling by ERBB2", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-2029481:r:FCGR activation", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-DRE-5673001:r:RAF/MAP kinase cascade", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-191650:r:Regulation of gap junction activity", "R-BTA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-DME-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-BTA-8866376:r:Reelin signalling pathway", "R-MMU-9706374:r:FLT3 signaling through SRC family kinases", "R-DRE-69231:r:Cyclin D associated events in G1", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-399954:r:Sema3A PAK dependent Axon repulsion", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-BTA-9706369:r:Negative regulation of FLT3", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-GGA-3928662:r:EPHB-mediated forward signaling", "R-CEL-525793:r:Myogenesis", "R-HSA-373753:r:Nephrin family interactions", "R-HSA-9706374:r:FLT3 signaling through SRC family kinases", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-3928664:r:Ephrin signaling", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-DRE-418594:r:G alpha (i) signalling events", "R-DRE-1253288:r:Downregulation of ERBB4 signaling", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-SSC-9032759:r:NTRK2 activates RAC1", "R-DRE-354192:r:Integrin signaling", "R-CEL-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-373753:r:Nephrin family interactions", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-DRE-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-389359:r:CD28 dependent Vav1 pathway", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-CEL-186763:r:Downstream signal transduction", "R-MMU-6798695:r:Neutrophil degranulation", "R-GGA-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-BTA-354192:r:Integrin signaling", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DRE-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-RNO-432142:r:Platelet sensitization by LDL", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-399956:r:CRMPs in Sema3A signaling", "R-CEL-8849472:r:PTK6 Down-Regulation", "R-CEL-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-912631:r:Regulation of signaling by CBL", "R-RNO-1295596:r:Spry regulation of FGF signaling", "R-DME-525793:r:Myogenesis", "R-MMU-8849470:r:PTK6 Regulates Cell Cycle", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-210990:r:PECAM1 interactions", "R-BTA-5674135:r:MAP2K and MAPK activation", "R-CEL-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-8849473:r:PTK6 Expression", "R-DME-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-525793:r:Myogenesis", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-9603381:r:Activated NTRK3 signals through PI3K", "R-MMU-389948:r:Co-inhibition by PD-1", "R-CEL-418592:r:ADP signalling through P2Y purinoceptor 1", "R-GGA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-GGA-389356:r:Co-stimulation by CD28", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-BTA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-1227986:r:Signaling by ERBB2", "R-SSC-2424491:r:DAP12 signaling", "R-CEL-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-982772:r:Growth hormone receptor signaling", "R-GGA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8876493:r:InlA-mediated entry of Listeria monocytogenes into host cells", "R-HSA-186763:r:Downstream signal transduction", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-2424491:r:DAP12 signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-SSC-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-8866376:r:Reelin signalling pathway", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-5621480:r:Dectin-2 family", "R-SSC-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-RNO-9766229:r:Degradation of CDH1", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-8874081:r:MET activates PTK2 signaling", "R-HSA-8866376:r:Reelin signalling pathway", "R-RNO-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling", "R-MMU-177929:r:Signaling by EGFR", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-CEL-8849470:r:PTK6 Regulates Cell Cycle", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-MMU-210990:r:PECAM1 interactions", "R-RNO-202433:r:Generation of second messenger molecules", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-1433559:r:Regulation of KIT signaling", "R-CEL-5621575:r:CD209 (DC-SIGN) signaling", "R-RNO-373753:r:Nephrin family interactions", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-5673000:r:RAF activation", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-MMU-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-8939245:r:RUNX1 regulates transcription of genes involved in BCR signaling", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-RNO-210990:r:PECAM1 interactions", "R-DRE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8853659:r:RET signaling", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-HSA-9603381:r:Activated NTRK3 signals through PI3K", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-DRE-5621480:r:Dectin-2 family", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-RNO-5673000:r:RAF activation", "R-DME-9013149:r:RAC1 GTPase cycle", "R-SSC-389356:r:Co-stimulation by CD28", "R-HSA-418592:r:ADP signalling through P2Y purinoceptor 1", "R-HSA-2424491:r:DAP12 signaling", "R-RNO-2029481:r:FCGR activation", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-SSC-3928662:r:EPHB-mediated forward signaling", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-GGA-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-1433559:r:Regulation of KIT signaling", "R-DRE-430116:r:GP1b-IX-V activation signalling", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-DME-416482:r:G alpha (12/13) signalling events", "R-HSA-1236974:r:ER-Phagosome pathway", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-BTA-2424491:r:DAP12 signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-RNO-6798695:r:Neutrophil degranulation", "R-SSC-1227986:r:Signaling by ERBB2", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-BTA-375165:r:NCAM signaling for neurite out-growth", "R-GGA-114604:r:GPVI-mediated activation cascade", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-BTA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-RNO-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-RNO-5690714:r:CD22 mediated BCR regulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-HSA-8849470:r:PTK6 Regulates Cell Cycle", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-CEL-354192:r:Integrin signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-SSC-2029481:r:FCGR activation", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-HSA-9020558:r:Interleukin-2 signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-MMU-437239:r:Recycling pathway of L1", "R-MMU-912631:r:Regulation of signaling by CBL", "R-MMU-8849474:r:PTK6 Activates STAT3", "R-RNO-9603381:r:Activated NTRK3 signals through PI3K", "R-BTA-3928664:r:Ephrin signaling", "R-RNO-1227986:r:Signaling by ERBB2", "R-MMU-9706369:r:Negative regulation of FLT3", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-CEL-430116:r:GP1b-IX-V activation signalling", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-69231:r:Cyclin D associated events in G1", "R-DRE-8874081:r:MET activates PTK2 signaling", "R-RNO-2454202:r:Fc epsilon receptor (FCERI) signaling", 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Down-Regulation", "R-RNO-8853659:r:RET signaling", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-456926:r:Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-SSC-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-MMU-8853659:r:RET signaling", "R-GGA-5621480:r:Dectin-2 family", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-CEL-177929:r:Signaling by EGFR", "R-MMU-982772:r:Growth hormone receptor signaling", "R-DRE-1433559:r:Regulation of KIT signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-BTA-912631:r:Regulation of signaling by CBL", "R-GGA-6798695:r:Neutrophil degranulation", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CEL-432142:r:Platelet sensitization by LDL", "R-HSA-982772:r:Growth hormone receptor signaling", "R-DRE-210990:r:PECAM1 interactions", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-BTA-389948:r:Co-inhibition by PD-1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-DRE-177929:r:Signaling by EGFR", "R-HSA-9620244:r:Long-term potentiation", "R-GGA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-GGA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-BTA-9766229:r:Degradation of CDH1", "R-MMU-69231:r:Cyclin D associated events in G1", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-CEL-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-BTA-389356:r:Co-stimulation by CD28", "R-CEL-437239:r:Recycling pathway of L1", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-416476:r:G alpha (q) signalling events", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-SSC-3928664:r:Ephrin signaling", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-9032759:r:NTRK2 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"R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9032500:r:Activated NTRK2 signals through FYN", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-CEL-418594:r:G alpha (i) signalling events", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-RNO-180292:r:GAB1 signalosome", "R-RNO-389356:r:Co-stimulation by CD28", "R-CEL-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-GGA-1433559:r:Regulation of KIT signaling", "R-MMU-418592:r:ADP signalling through P2Y purinoceptor 1", "R-GGA-432142:r:Platelet sensitization by LDL", "R-BTA-1433559:r:Regulation of KIT signaling", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-HSA-418594:r:G alpha (i) signalling events", "R-DRE-8853659:r:RET signaling", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-389513:r:Co-inhibition by CTLA4", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-1295596:r:Spry regulation of FGF signaling", "R-MMU-2424491:r:DAP12 signaling", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-DRE-373753:r:Nephrin family interactions", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-DRE-3928663:r:EPHA-mediated growth cone collapse"], "type": "Family"}, "IPR050199": {"description": "Immunoglobulin Heavy Variable", "go_ids": [], "go_terms": [], "name": "IgHV", "pathway_ids": ["R-HSA-173623", "R-HSA-2871796", "R-HSA-2168880", "R-HSA-2029485", "R-HSA-2029481", "R-MMU-173623", "R-MMU-2871796", "R-HSA-2871837", "R-HSA-2454202", "R-HSA-977606", 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vascular wall", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-166663:r:Initial triggering of complement", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2454202:r:Fc epsilon receptor (FCERI) signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-5690714:r:CD22 mediated BCR regulation", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-2029481:r:FCGR activation", "R-MMU-198933:r:Immunoregulatory interactions between a 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["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638771:r:Action of antimicrobials"], "type": "Family"}, "IPR050221": {"description": "26S Proteasome Regulatory ATPase", "go_ids": [], "go_terms": [], "name": "26S_Proteasome_ATPase", "pathway_ids": ["R-HSA-174178", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-HSA-8951664", "R-BTA-9755511", "R-HSA-9010553", "R-CEL-8941858", "R-HSA-75815", "R-MMU-8948751", "R-CEL-532668", "R-DME-8948751", "R-SPO-5689880", "R-MMU-5689880", "R-CEL-1234176", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-DME-5676590", "R-RNO-8854050", "R-HSA-450408", "R-RNO-450408", "R-SCE-5689880", "R-HSA-211733", "R-HSA-532668", "R-DDI-6798695", "R-DME-4641257", "R-DME-432524", "R-HSA-5607761", "R-DDI-174084", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-CEL-8948751", "R-MMU-9766229", "R-BTA-349425", "R-RNO-69481", "R-HSA-174154", "R-DDI-187577", "R-RNO-9932298", 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"R-DME-8939902", "R-CEL-382556", "R-CEL-5689603", "R-RNO-174154", "R-MMU-9929356", "R-DME-4608870", "R-SCE-5668541", "R-RNO-9929356", "R-DME-9762114", "R-HSA-69481", "R-BTA-174084", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-HSA-4641258", "R-SPO-5689603", "R-RNO-8939236", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-BTA-4641258", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-RNO-2467813", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-DME-8941858", "R-SPO-6798695", "R-MMU-5610780", "R-DME-9954709", "R-BTA-382556", "R-CEL-8939902", "R-MMU-9755511", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-DME-5689603", "R-HSA-5362768", "R-DDI-9954709", "R-DME-216167", "R-MMU-5658442", "R-RNO-8852276", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-RNO-9907900", "R-BTA-8948751", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-RNO-8941858", "R-RNO-5607764", "R-HSA-69017", "R-RNO-1169091", "R-BTA-9020702", "R-RNO-9766229", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-HSA-202424", "R-CEL-4641257", "R-DDI-174154", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-MMU-174154", "R-BTA-1234176", "R-MMU-69017", "R-CEL-195253", "R-DME-5658442", "R-MMU-9020702", "R-RNO-5687128", "R-RNO-382556", "R-MMU-69481", "R-BTA-350562", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-BTA-68867", "R-HSA-1234176", "R-RNO-4641258", "R-MMU-68867", "R-HSA-9931269", "R-HSA-9929491", "R-DME-209461", "R-RNO-5689880", "R-DME-75815", "R-RNO-8951664", "R-DME-69601", "R-DME-1234176", "R-HSA-1236974", "R-CEL-4608870", "R-MMU-5687128", "R-RNO-5358346", "R-DME-5358346", "R-RNO-6798695", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-DME-9907900", "R-RNO-4641257", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-MMU-532668", "R-RNO-349425", "R-MMU-9762114", "R-BTA-174184", "R-MMU-195253", "R-MMU-202424", "R-MMU-382556", "R-BTA-8939236", "R-HSA-5610780", "R-DME-209360", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-DME-432626", "R-MMU-5607761", "R-DME-8854050", "R-CEL-5689880", "R-HSA-8939902", "R-MMU-8939902", "R-DME-174178", "R-RNO-195253", "R-HSA-8939236", "R-DDI-8854050", "R-BTA-983168", "R-MMU-5607764", "R-DME-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577", "R-HSA-5676590", "R-DDI-5632684", "R-BTA-9929491", "R-HSA-4641257", "R-RNO-202424", "R-MMU-9929491", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-RNO-5607761", "R-HSA-68867", "R-DME-174154", "R-MMU-9907900", "R-CEL-4641258", "R-DDI-5658442", "R-BTA-450408", "R-HSA-8941858", "R-HSA-9755511", "R-RNO-9931269", "R-CEL-9929491", "R-DME-9755511", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-RNO-532668", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-RNO-174084", "R-HSA-8948751", "R-HSA-5689603", "R-RNO-983168", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-DME-1169091", "R-HSA-187577", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-BTA-8941858", "R-DME-4641258", "R-HSA-174184", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-CEL-1236978", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DME-532668", "R-DME-538864", "R-DDI-983168", "R-SCE-9907900", "R-HSA-5668541", "R-HSA-9929356", "R-CEL-69601", "R-CEL-68949", "R-DME-5632684", "R-HSA-5687128", "R-DME-432395", "R-RNO-5658442", "R-MMU-983168", "R-RNO-5610785", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-69481:r:G2/M Checkpoints", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9907900:r:Proteasome assembly", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-CEL-5689603:r:UCH proteinases", "R-RNO-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-4641258:r:Degradation of DVL", "R-SPO-5689603:r:UCH proteinases", "R-RNO-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-4641258:r:Degradation of DVL", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-RNO-5689603:r:UCH proteinases", "R-RNO-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-5689603:r:UCH proteinases", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-RNO-9907900:r:Proteasome assembly", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-5689603:r:UCH proteinases", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-9766229:r:Degradation of CDH1", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-350562:r:Regulation of ornithine 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activation", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2672351:r:Stimuli-sensing channels", "R-DME-111932:r:CaMK IV-mediated phosphorylation of CREB", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-DME-111933:r:Calmodulin induced events", "R-MMU-111957:r:Cam-PDE 1 activation", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9022535:r:Loss of phosphorylation of MECP2 at T308", "R-MMU-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR050232": {"description": "F-box/LRR-repeat protein 13/AtMIF1-like", "go_ids": [], "go_terms": [], "name": "FBL13/AtMIF1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050233": {"description": "Arabidopsis thaliana F-box", "go_ids": [], "go_terms": [], "name": "A_thaliana_F-box", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050234": {"description": "Nuclear hormone receptor family NR1 subfamily", "go_ids": [], "go_terms": [], "name": "Nuclear_hormone_rcpt_NR1", "pathway_ids": ["R-HSA-1989781", "R-RNO-193807", "R-HSA-2151201", "R-BTA-9841922", "R-CEL-383280", "R-HSA-1368108", "R-HSA-9841922", "R-BTA-9623433", "R-DME-9623433", "R-MMU-159418", "R-HSA-9844594", "R-SSC-383280", "R-DME-9616222", "R-HSA-9933387", "R-HSA-8943724", "R-HSA-9707564", "R-HSA-4090294", "R-DME-400206", "R-RNO-4090294", "R-RNO-383280", "R-RNO-8866427", "R-CFA-9707564", "R-DME-383280", "R-SSC-4090294", "R-MMU-200425", "R-CEL-9841922", "R-MMU-192105", "R-HSA-192105", "R-CFA-200425", "R-HSA-193807", "R-RNO-196791", "R-MMU-381340", "R-CEL-4090294", "R-DRE-196791", "R-MMU-211976", "R-MMU-8866427", "R-MMU-196791", "R-RNO-381340", "R-CFA-383280", "R-HSA-400206", "R-RNO-9841922", "R-RNO-211976", "R-RNO-193368", "R-DRE-383280", "R-HSA-211976", "R-MMU-400206", "R-HSA-9623433", "R-MMU-193807", "R-HSA-9029558", "R-DME-200425", "R-GGA-4090294", "R-DME-8866427", "R-HSA-193368", "R-CEL-196791", "R-RNO-9029569", "R-RNO-192105", "R-HSA-196791", "R-MMU-383280", "R-DME-196791", "R-BTA-4090294", "R-CFA-400206", "R-BTA-9029569", "R-RNO-159418", "R-MMU-9841922", "R-BTA-8866427", "R-MMU-4090294", "R-HSA-9029569", "R-DME-4090294", "R-HSA-5362517", "R-MMU-9029569", "R-HSA-9931509", "R-CFA-5362517", "R-DME-159418", "R-HSA-9022707", "R-RNO-400206", "R-MMU-193368", "R-MMU-9623433", "R-DME-9707564", "R-HSA-9031525", "R-HSA-381340", "R-BTA-381340", "R-HSA-9632974", "R-HSA-9707616", "R-RNO-9707564", "R-GGA-383280", "R-DME-5362517", "R-RNO-9623433", "R-HSA-9931510", "R-HSA-8866427", "R-HSA-383280", "R-BTA-383280", "R-DRE-4090294", "R-HSA-200425", "R-DME-9841922", "R-SSC-196791", "R-MMU-5362517", "R-HSA-159418", "R-HSA-9031528", "R-DME-9029569", "R-HSA-2426168", "R-DME-381340", "R-MMU-9707564"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-CEL-383280:r:Nuclear Receptor transcription pathway", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-DME-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-MMU-159418:r:Recycling of bile acids and salts", "R-HSA-9844594:r:Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "R-SSC-383280:r:Nuclear Receptor transcription pathway", "R-DME-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-4090294:r:SUMOylation of intracellular receptors", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-4090294:r:SUMOylation of intracellular receptors", "R-RNO-383280:r:Nuclear Receptor transcription pathway", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-CFA-9707564:r:Cytoprotection by HMOX1", "R-DME-383280:r:Nuclear Receptor transcription pathway", "R-SSC-4090294:r:SUMOylation of intracellular receptors", "R-MMU-200425:r:Carnitine shuttle", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-192105:r:Synthesis of bile acids and bile salts", "R-HSA-192105:r:Synthesis of bile acids and bile salts", "R-CFA-200425:r:Carnitine shuttle", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-CEL-4090294:r:SUMOylation of intracellular receptors", "R-DRE-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-211976:r:Endogenous sterols", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-CFA-383280:r:Nuclear Receptor transcription pathway", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-211976:r:Endogenous sterols", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DRE-383280:r:Nuclear Receptor transcription pathway", "R-HSA-211976:r:Endogenous sterols", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DME-200425:r:Carnitine shuttle", "R-GGA-4090294:r:SUMOylation of intracellular receptors", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-CEL-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-192105:r:Synthesis of bile acids and bile salts", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-DME-196791:r:Vitamin D (calciferol) metabolism", "R-BTA-4090294:r:SUMOylation of intracellular receptors", "R-CFA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-BTA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-RNO-159418:r:Recycling of bile acids and salts", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-MMU-4090294:r:SUMOylation of intracellular receptors", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-DME-4090294:r:SUMOylation of intracellular receptors", "R-HSA-5362517:r:Signaling by Retinoic Acid", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-CFA-5362517:r:Signaling by Retinoic Acid", "R-DME-159418:r:Recycling of bile acids and salts", "R-HSA-9022707:r:MECP2 regulates transcription factors", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-9031525:r:NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-BTA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9632974:r:NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "R-HSA-9707616:r:Heme signaling", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-GGA-383280:r:Nuclear Receptor transcription pathway", "R-DME-5362517:r:Signaling by Retinoic Acid", "R-RNO-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-BTA-383280:r:Nuclear Receptor transcription pathway", "R-DRE-4090294:r:SUMOylation of intracellular receptors", "R-HSA-200425:r:Carnitine shuttle", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-SSC-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-5362517:r:Signaling by Retinoic Acid", "R-HSA-159418:r:Recycling of bile acids and salts", "R-HSA-9031528:r:NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose", "R-DME-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-DME-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR050235": {"description": "Casein kinase 1/Serine/threonine-protein kinase-like", "go_ids": [], "go_terms": [], "name": "CK1_Ser-Thr_kinase-like", "pathway_ids": ["R-HSA-9013405", "R-DME-209155", "R-MMU-204005", "R-BTA-202670", "R-BTA-5610785", "R-CEL-195253", "R-RNO-5635838", "R-HSA-380284", "R-MMU-9013408", "R-MMU-9013404", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-BTA-380259", "R-RNO-380320", "R-HSA-380320", "R-DME-390150", "R-GGA-196299", "R-HSA-5358747", "R-RNO-196299", "R-SCE-6791226", "R-BTA-2565942", "R-HSA-9931530", "R-BTA-5620912", "R-HSA-5467337", "R-BTA-69601", "R-RNO-380284", "R-BTA-2995383", "R-BTA-204005", "R-DRE-2995383", "R-HSA-9013408", "R-MMU-5620912", "R-HSA-5610783", "R-DME-390023", "R-DME-209413", "R-HSA-5358752", "R-MMU-6791226", "R-HSA-5358749", "R-DME-432524", "R-DME-538898", "R-MMU-196299", "R-HSA-202670", "R-MMU-5635838", "R-BTA-6791226", "R-MMU-380259", "R-BTA-2980766", "R-DME-209461", "R-CEL-2995383", "R-MMU-380270", "R-HSA-9931521", "R-BTA-196299", "R-DRE-380320", "R-HSA-5467340", "R-HSA-9694631", "R-RNO-6791226", "R-HSA-204005", "R-HSA-9013404", "R-MMU-9013423", "R-DME-432620", "R-HSA-9013149", "R-HSA-2980766", "R-HSA-5635838", "R-HSA-6791226", "R-MMU-4641262", "R-GGA-195253", "R-DME-69601", "R-BTA-4641262", "R-DME-5610785", "R-MMU-8854518", "R-RNO-380270", "R-HSA-5358751", "R-HSA-5610785", "R-DME-432553", "R-RNO-4641262", "R-DME-2995383", "R-SCE-69601", "R-BTA-195253", "R-DDI-6791226", "R-HSA-5467348", "R-RNO-69601", "R-MMU-201688", "R-GGA-5610785", "R-RNO-5620912", "R-MMU-380284", "R-DME-195253", "R-HSA-196299", "R-MMU-69601", "R-DME-209214", "R-HSA-2565942", "R-HSA-9013423", "R-DME-5635838", "R-RNO-2565942", "R-DME-209396", "R-MMU-5610785", "R-MMU-2980766", "R-DME-209159", "R-HSA-5339716", "R-DDI-69601", "R-HSA-4641262", "R-BTA-380320", "R-DME-432490", "R-GGA-5635838", "R-CEL-1660661", "R-HSA-5620912", "R-BTA-380284", "R-MMU-202670", "R-MMU-195253", "R-MMU-2995383", "R-HSA-195253", "R-DME-209190", "R-GGA-69601", "R-BTA-5635838", "R-DME-209360", "R-HSA-201688", "R-RNO-8854518", "R-HSA-69601", "R-DME-196299", "R-HSA-380270", "R-HSA-1660661", "R-HSA-2995383", "R-RNO-204005", "R-RNO-380259", "R-DME-201688", "R-CEL-69601", "R-CEL-196299", "R-BTA-8854518", "R-DME-209440", 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"R-MMU-174184", "R-HSA-8856825", "R-DME-9932298", "R-DME-9020702", "R-DDI-156827", "R-CEL-9762114", "R-DME-5689880", "R-HSA-5358346", "R-CEL-8951664", "R-SPO-350562", "R-HSA-6798695", "R-MMU-5632684", "R-SPO-9907900", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-MMU-5689901", "R-DDI-1236978", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-72706", "R-MMU-8951664", "R-DME-8939902", "R-HSA-5693607", "R-CEL-5689603", "R-CEL-382556", "R-MMU-9929356", "R-BTA-5693607", "R-DME-4608870", "R-SCE-5668541", "R-HSA-69481", "R-BTA-156827", "R-DME-9762114", "R-RNO-156827", "R-SPO-72706", "R-DDI-8948751", "R-HSA-5678895", "R-RNO-5693607", "R-DDI-6781823", "R-HSA-4641258", "R-RNO-69473", "R-SPO-5689603", "R-DRE-5696394", "R-DME-1236978", "R-CEL-6781823", "R-HSA-180585", "R-SPO-1236978", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-DME-5607764", "R-DME-209406", "R-BTA-72649", "R-MMU-5693571", "R-DME-2871837", "R-GGA-72702", "R-CEL-5689901", "R-DME-8941858", "R-SPO-72702", "R-MMU-5610780", "R-SPO-6798695", "R-BTA-69473", "R-DME-9954709", "R-CEL-72702", "R-CEL-8939902", "R-MMU-9755511", "R-CEL-72695", "R-MMU-9954709", "R-DDI-75815", "R-MMU-72649", "R-HSA-2871837", "R-HSA-5362768", "R-DME-5689603", "R-DDI-9954709", "R-DME-216167", "R-MMU-5658442", "R-HSA-174084", "R-MMU-4608870", "R-DDI-69017", "R-DME-72695", "R-MMU-72702", "R-HSA-1236978", "R-HSA-69601", "R-HSA-72689", "R-HSA-983168", "R-HSA-5632684", "R-DRE-72649", "R-DDI-349425", "R-HSA-69017", "R-DRE-72689", "R-DDI-450408", "R-MMU-1236978", "R-CEL-350562", "R-HSA-202424", "R-DDI-174154", "R-CEL-4641257", "R-MMU-450408", "R-HSA-9020702", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-MMU-174154", "R-RNO-5693565", "R-MMU-69017", "R-MMU-9020702", "R-CEL-195253", "R-DME-5658442", "R-HSA-5693565", "R-RNO-5689901", "R-MMU-69481", "R-DDI-8856825", "R-MMU-75815", "R-MMU-5668541", "R-DME-2467813", "R-HSA-8854050", "R-HSA-5610783", "R-MMU-174084", "R-BTA-5689901", "R-HSA-1234176", "R-HSA-9931269", "R-MMU-68867", "R-HSA-9929491", "R-HSA-69473", "R-DME-209461", "R-RNO-5693571", "R-HSA-72702", "R-RNO-72649", "R-GGA-72649", "R-DME-75815", "R-HSA-5696394", "R-CEL-72649", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-MMU-5687128", "R-DME-72702", "R-CEL-8856825", "R-DME-5358346", "R-CEL-72689", "R-SPO-72689", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-HSA-2467813", "R-MMU-8852276", "R-MMU-72689", "R-SCE-6798695", "R-MMU-68949", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-MMU-6781823", "R-DME-9907900", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-MMU-9762114", "R-DRE-6781823", "R-MMU-195253", "R-MMU-202424", "R-MMU-5693607", "R-MMU-72695", "R-MMU-382556", "R-HSA-5610780", "R-DME-209360", "R-DDI-5687128", "R-DDI-9907900", "R-SCE-1236978", "R-DME-72689", "R-MMU-1169091", "R-RNO-72702", "R-DME-432626", "R-HSA-72649", "R-MMU-5607761", "R-MMU-156827", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-HSA-5693571", "R-DRE-72702", "R-MMU-8939902", "R-DME-174178", "R-BTA-5693571", "R-HSA-8939236", "R-DDI-8854050", "R-MMU-5607764", "R-DME-6781823", "R-DME-8951664", "R-DRE-8951664", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-RNO-72695", "R-BTA-72689", "R-DDI-5632684", "R-HSA-4641257", "R-MMU-9929491", "R-HSA-174113", "R-BTA-72695", "R-HSA-68867", "R-DRE-5689901", "R-MMU-9907900", "R-DME-174154", "R-CEL-4641258", "R-DRE-72695", "R-DDI-5658442", "R-DDI-72695", "R-HSA-8941858", "R-HSA-9755511", "R-CEL-9929491", "R-DME-9755511", "R-CEL-156827", "R-HSA-1169091", "R-HSA-5658442", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-HSA-5689603", "R-SPO-156827", "R-GGA-72695", "R-DME-450408", "R-DDI-72702", "R-HSA-5689901", "R-HSA-187577", "R-DME-1169091", "R-DME-156827", "R-DDI-9755511", "R-MMU-8856825", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-HSA-174184", "R-RNO-72689", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-DME-68949", "R-XTR-72695", "R-DRE-8856825", "R-DME-8856825", "R-DRE-156827", "R-CEL-1236978", "R-CEL-9954709", "R-SPO-72649", "R-SPO-72695", "R-HSA-382556", "R-XTR-156827", "R-HSA-8852276", "R-XTR-5689901", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-HSA-5687128", "R-DME-5632684", "R-DME-432395", "R-MMU-983168", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-5689901:r:Metalloprotease DUBs", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-432524:r:Degradation of PER", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9766229:r:Degradation of CDH1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-5689901:r:Metalloprotease DUBs", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-72649:r:Translation initiation complex formation", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-DME-9020702:r:Interleukin-1 signaling", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-5689901:r:Metalloprotease DUBs", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-4641258:r:Degradation of DVL", "R-RNO-69473:r:G2/M DNA damage checkpoint", "R-SPO-5689603:r:UCH proteinases", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-BTA-72649:r:Translation initiation complex formation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-GGA-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-5689901:r:Metalloprotease DUBs", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-SPO-6798695:r:Neutrophil degranulation", "R-BTA-69473:r:G2/M DNA damage checkpoint", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-DME-5689603:r:UCH proteinases", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DRE-72649:r:Translation initiation complex formation", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-4641257:r:Degradation of AXIN", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5689901:r:Metalloprotease DUBs", "R-MMU-69481:r:G2/M Checkpoints", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5689901:r:Metalloprotease DUBs", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-RNO-72649:r:Translation initiation complex formation", "R-GGA-72649:r:Translation initiation complex formation", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-72649:r:Translation initiation complex formation", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-9907900:r:Proteasome assembly", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-9907900:r:Proteasome assembly", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", 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"R-DRE-5689901:r:Metalloprotease DUBs", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-CEL-4641258:r:Degradation of DVL", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is 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"R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5689603:r:UCH proteinases", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-68949:r:Orc1 removal from chromatin", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-72649:r:Translation initiation complex formation", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-XTR-5689901:r:Metalloprotease DUBs", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-68949:r:Orc1 removal from chromatin", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-5632684:r:Hedgehog 'on' state", "R-DME-432395:r:Degradation of TIM", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Family"}, "IPR050243": {"description": "Probable phosphatase PHP", "go_ids": [], "go_terms": [], "name": "PHP_phosphatase", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone 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"go_ids": [], "go_terms": [], "name": "Auton_GlycylRad_Cofactor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050245": {"description": "Bacterial extracellular foldase PrsA", "go_ids": [], "go_terms": [], "name": "PrsA_foldase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050248": {"description": "Polysaccharide deacetylase, ArnD subfamily", "go_ids": [], "go_terms": [], "name": "Polysacc_deacetylase_ArnD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050249": {"description": "Pseudomonas-type Homoserine Kinase", "go_ids": [], "go_terms": [], "name": "Pseudomonas-type_ThrB", "pathway_ids": ["PWY-702", "R-BTA-71064", "R-HSA-71064", "R-MMU-71064", "R-DRE-71064"], "pathways": ["PWY-702:t:L-methionine biosynthesis II", "R-BTA-71064:r:Lysine catabolism", "R-HSA-71064:r:Lysine catabolism", "R-MMU-71064:r:Lysine catabolism", "R-DRE-71064:r:Lysine catabolism"], "type": "Family"}, "IPR050250": {"description": "Macrolide Exporter MacB", "go_ids": [], "go_terms": [], "name": "Macrolide_Exporter_MacB", "pathway_ids": ["R-HSA-9913143", "R-HSA-9638334", "R-HSA-9760173"], "pathways": ["R-HSA-9913143:r:Antimicrobial resistance", "R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR050251": {"description": "HpcH/HpaI aldolase", "go_ids": [], "go_terms": [], "name": "HpcH-HpaI_aldolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050252": {"description": "Beta/Gamma-Crystallin", "go_ids": [], "go_terms": [], "name": "Beta/Gamma-Crystallin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050253": {"description": "Seed Storage and Functional Proteins", "go_ids": [], "go_terms": [], "name": "Seed_Storage-Functional", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050254": {"description": "DNA-directed RNA polymerase, subunit beta'', eukaryote", "go_ids": [], "go_terms": [], "name": "RNA_pol_beta''_euk", "pathway_ids": [], "pathways": [], 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"R-CEL-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-MMU-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-8964539:r:Glutamate and glutamine metabolism", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-DME-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-SPO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-RNO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "type": "Family"}, "IPR050293": {"description": "Light-independent protochlorophyllide reductase", "go_ids": [], "go_terms": [], "name": "LIPOR_BchN/ChlN", "pathway_ids": ["PWY-5531", "PWY-7159"], "pathways": ["PWY-5531:t:3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)", "PWY-7159:t:3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "type": "Family"}, "IPR050294": {"description": "Ion-translocating oxidoreductase complex subunit B", "go_ids": [], "go_terms": [], "name": "RnfB_subfamily", "pathway_ids": ["R-MTU-936721"], "pathways": ["R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Family"}, "IPR050296": {"description": "Antennapedia-type homeobox", "go_ids": [], "go_terms": [], "name": "Antp_homeobox", "pathway_ids": ["R-HSA-9830364"], "pathways": ["R-HSA-9830364:r:Formation of the nephric duct"], "type": "Family"}, "IPR050297": {"description": "Lipid A-modifying glycosyltransferase 83", "go_ids": [], "go_terms": [], "name": "LipidA_mod_glycosyltrf_83", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050298": {"description": "Gram-negative bacterial outer membrane porin", "go_ids": [], "go_terms": [], "name": "Gram-neg_bact_OMP", "pathway_ids": ["R-HSA-5603041", "R-HSA-1236974", "R-HSA-5602498", "R-HSA-3000484", "R-HSA-166058", "R-HSA-168179"], "pathways": ["R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", 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"go_ids": [], "go_terms": [], "name": "Tyrosinase-like", "pathway_ids": ["R-SSC-5662702", "R-HSA-9824585", "R-HSA-5662702", "R-CEL-5662702", "R-MMU-5662702"], "pathways": ["R-SSC-5662702:r:Melanin biosynthesis", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-5662702:r:Melanin biosynthesis", "R-CEL-5662702:r:Melanin biosynthesis", "R-MMU-5662702:r:Melanin biosynthesis"], "type": "Family"}, "IPR050318": {"description": "DENR/SUI1 Translation Initiation Factor", "go_ids": [], "go_terms": [], "name": "DENR/SUI1_TIF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050319": {"description": "ABC Transporter ATP-Binding", "go_ids": [], "go_terms": [], "name": "ABC_transp_ATP-bind", "pathway_ids": ["R-HSA-9927020"], "pathways": ["R-HSA-9927020:r:Heme assimilation"], "type": "Family"}, "IPR050320": {"description": "Protein N5-glutamine methyltransferase", "go_ids": [], "go_terms": [], "name": "N5-glutamine_MTase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050321": {"description": "Glycosyltransferase 2/OpgH subfamily", "go_ids": [], "go_terms": [], "name": "Glycosyltr_2/OpgH_subfam", "pathway_ids": ["PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-9931953", "PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213"], "pathways": ["PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-9931953:r:Biofilm formation", "PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism"], "type": "Family"}, "IPR050322": {"description": "Iron-sulfur cluster assembly and transfer HesB/IscA", "go_ids": [], "go_terms": [], "name": "Fe-S_cluster_asmbl/transfer", "pathway_ids": ["R-RNO-9854311", "R-HSA-1362409", "R-HSA-9854311", "R-BTA-9854311", "R-SCE-1362409", "R-RNO-1362409", "R-MMU-9854311", "R-MMU-1362409", "R-BTA-1362409", "R-DDI-1362409", "R-SPO-1362409", "R-DME-1362409"], "pathways": ["R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-RNO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-BTA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DDI-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DME-1362409:r:Mitochondrial iron-sulfur cluster biogenesis"], "type": "Family"}, "IPR050323": {"description": "Universal ribosomal protein uL10", "go_ids": [], "go_terms": [], "name": "Ribosomal_protein_uL10", "pathway_ids": ["R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SPO-975957", "R-SCE-9954709", "R-DRE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-MMU-9954716", "R-CEL-975956", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-HSA-1799339", "R-SPO-975956", "R-HSA-2408557", "R-MMU-6791226", "R-RNO-975957", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-DRE-9954714", "R-SCE-975956", "R-CEL-1799339", "R-HSA-8950505", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-DRE-1799339", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-CEL-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-MMU-72689", "R-SCE-72706", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DME-975956", "R-DRE-975956", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-HSA-975957", "R-DME-9954714", "R-DRE-72689", "R-DRE-9954716", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and 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of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR050324": {"description": "CDP-alcohol phosphatidyltransferase class-I", "go_ids": [], "go_terms": [], "name": "CDP-alcohol_PTase-I", "pathway_ids": ["PWY-5668", "PWY-7817", "PWY-5269", "R-SCE-1483076", "R-SPO-1482925", "R-CEL-1482925", "R-MMU-1483076", "R-DME-1483076", "R-SPO-1483076", "R-RNO-1483076", "R-SCE-1482925", "R-RNO-1482925", "R-HSA-1483076", "R-CEL-1483076", "R-MMU-1482925", "R-DME-1482925", "R-HSA-1482925"], "pathways": ["PWY-5668:t:cardiolipin biosynthesis I", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", 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"PWY-8418", "PWY-7496", "PWY-8453", "PWY-981", "PWY-8432", "PWY-8293", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-5846", "PWY-7931", "PWY-5109", "PWY-7018", "PWY-5497", "PWY-6995", "PWY-8431", "PWY-8042", "PWY-3602", "PWY-1822", "PWY-7738", "PWY-7690", "PWY-7821", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-6409", "PWY-6899", "PWY-7742", "PWY-7652", "PWY-7471", "PWY-6917", "PWY-5784", "PWY-7741", "PWY-7771", "PWY-8402", "R-MMU-9646399", "R-HSA-9646399", "R-DRE-9646399", "R-MMU-3899300", "R-RNO-9646399", "R-HSA-9613829", "R-DME-9646399", "R-BTA-9646399", "R-BTA-3899300", "R-HSA-9615710", "R-HSA-3899300", "R-CEL-3899300", "R-SPO-3899300", "R-RNO-3899300", "R-CEL-9646399"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", 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"IPR050334": {"description": "Molybdenum import ATP-binding protein ModC", "go_ids": [], "go_terms": [], "name": "Molybdenum_import_ModC", "pathway_ids": ["PWY-8171"], "pathways": ["PWY-8171:t:molybdenum cofactor biosynthesis"], "type": "Family"}, "IPR050335": {"description": "ERT1/acuK gluconeogenesis transcription factor", "go_ids": [], "go_terms": [], "name": "ERT1_acuK_gluconeogen_tf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050336": {"description": "Chromosome-partitioning and nucleoid occlusion protein", "go_ids": [], "go_terms": [], "name": "Chromosome_partition/occlusion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050337": {"description": "L-rhamnose isomerase", "go_ids": [], "go_terms": [], "name": "L-rhamnose_isomerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050338": {"description": "DNA integrity scanning protein DisA", "go_ids": [], "go_terms": [], "name": "DisA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050339": {"description": "Cell Cycle and Stress Response Kinase", "go_ids": [], "go_terms": [], "name": "CC_SR_Kinase", "pathway_ids": ["R-HSA-9833109", "R-BTA-9909505", "R-DME-69273", "R-DDI-156711", "R-HSA-4755510", "R-HSA-9700645", "R-HSA-9833482", "R-RNO-9833482", "R-RNO-156711", "R-HSA-69202", "R-RNO-1169408", "R-HSA-69273", "R-HSA-381042", "R-RNO-9840373", "R-MMU-75035", "R-HSA-1169408", "R-CEL-381042", "R-RNO-69478", "R-DME-69478", "R-DME-381042", "R-MMU-381042", "R-HSA-9909505", "R-MMU-69202", "R-MMU-9833482", "R-HSA-9725370", "R-HSA-69656", "R-HSA-75035", "R-RNO-69656", "R-BTA-381042", "R-PFA-9833482", "R-CEL-69273", "R-HSA-9840373", "R-RNO-69202", "R-MMU-156711", "R-DME-69202", "R-HSA-69478", "R-HSA-9633012", "R-HSA-156711", "R-DDI-69656", "R-HSA-983231", "R-DME-156711", "R-RNO-75035", "R-CEL-9833482", "R-HSA-9755511", "R-RNO-381042", "R-MMU-1169408", "R-RNO-69273", "R-MMU-69478", "R-HSA-9648895", "R-DME-9833482", "R-MMU-69656", "R-CEL-1169408", "R-HSA-909733", "R-CEL-156711", "R-CEL-69478", "R-DME-75035", "R-SCE-156711", "R-HSA-169131", "R-MMU-69273", "R-PFA-381042", "R-SPO-156711", "R-DDI-69202", "R-MMU-9840373", "R-DME-69656"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-BTA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-156711:r:Polo-like kinase mediated events", "R-HSA-4755510:r:SUMOylation of immune response proteins", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-9833482:r:PKR-mediated signaling", "R-RNO-9833482:r:PKR-mediated signaling", "R-RNO-156711:r:Polo-like kinase mediated events", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-381042:r:PERK regulates gene expression", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-MMU-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-381042:r:PERK regulates gene expression", "R-RNO-69478:r:G2/M DNA replication checkpoint", "R-DME-69478:r:G2/M DNA replication checkpoint", "R-DME-381042:r:PERK regulates gene expression", "R-MMU-381042:r:PERK regulates gene expression", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-RNO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-BTA-381042:r:PERK regulates gene expression", "R-PFA-9833482:r:PKR-mediated signaling", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-RNO-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-156711:r:Polo-like kinase mediated events", "R-DME-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-69478:r:G2/M DNA replication checkpoint", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-HSA-156711:r:Polo-like kinase mediated events", "R-DDI-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DME-156711:r:Polo-like kinase mediated events", "R-RNO-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-381042:r:PERK regulates gene expression", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-69478:r:G2/M DNA replication checkpoint", "R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-DME-9833482:r:PKR-mediated signaling", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-CEL-156711:r:Polo-like kinase mediated events", "R-CEL-69478:r:G2/M DNA replication checkpoint", "R-DME-75035:r:Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-SCE-156711:r:Polo-like kinase mediated events", "R-HSA-169131:r:Inhibition of PKR", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-PFA-381042:r:PERK regulates gene expression", "R-SPO-156711:r:Polo-like kinase mediated events", "R-DDI-69202:r:Cyclin E associated events during G1/S transition", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-DME-69656:r:Cyclin A:Cdk2-associated events at S phase entry"], "type": "Family"}, "IPR050340": {"description": "Cytosolic Fe-S Cluster Assembly Factor", "go_ids": [], "go_terms": [], "name": "Cytosolic_Fe-S_CAF", "pathway_ids": ["R-HSA-2564830"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly"], "type": "Family"}, "IPR050341": {"description": "Serine/threonine-protein phosphatase PP1-like", "go_ids": [], "go_terms": [], "name": "PP1-like", "pathway_ids": ["R-SSC-5673000", "R-RNO-5627123", "R-MMU-9770562", "R-MMU-2467813", "R-GGA-2565942", "R-MMU-5625740", "R-CEL-5673000", "R-MMU-68877", "R-MMU-2565942", "R-XTR-141444", "R-HSA-5673000", "R-HSA-9828806", "R-RNO-5625740", "R-HSA-9931530", "R-BTA-2565942", "R-CEL-9770562", "R-BTA-2500257", "R-SSC-2565942", "R-SSC-5625740", "R-XTR-5625740", "R-CEL-2500257", "R-RNO-5673000", "R-BTA-5625740", "R-SPO-2500257", "R-DME-538898", "R-MMU-141444", "R-DME-5627123", "R-MMU-5673000", "R-HSA-141444", "R-DME-2500257", "R-HSA-9648025", "R-SCE-2500257", "R-CFA-180024", "R-RNO-5663220", "R-RNO-180024", "R-DME-350416", "R-SPO-9770562", "R-HSA-9726840", "R-BTA-9770562", "R-MMU-5627123", "R-RNO-2467813", "R-BTA-9648025", "R-BTA-5673000", "R-GGA-5673000", "R-MMU-5663220", "R-RNO-141444", "R-HSA-5625900", "R-HSA-2467813", "R-RNO-2500257", "R-XTR-9770562", "R-XTR-2467813", "R-HSA-5625740", "R-DDI-9770562", "R-BTA-5663220", "R-DME-2565942", "R-DME-5625740", "R-BTA-5627123", "R-GGA-5627123", "R-HSA-2565942", "R-DME-9770562", "R-XTR-5627123", "R-BTA-2467813", "R-RNO-2565942", "R-CFA-9770562", "R-HSA-68877", "R-MMU-180024", "R-SSC-5627123", "R-GGA-9770562", "R-MMU-9648025", "R-HSA-180024", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-HSA-2500257", "R-HSA-9770562", "R-XTR-5663220", "R-DME-350480", "R-DDI-2500257", "R-XTR-68877", "R-HSA-9726842", "R-HSA-163560", "R-XTR-180024", "R-BTA-180024", "R-HSA-5627123", "R-XTR-2565942", "R-RNO-9770562", "R-HSA-5663220", "R-RNO-9648025", "R-SSC-9770562", "R-HSA-2173788", "R-BTA-141444", "R-XTR-2500257", "R-HSA-5627117"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-RNO-5627123:r:RHO GTPases activate PAKs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-5625740:r:RHO GTPases activate PKNs", "R-CEL-5673000:r:RAF activation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5673000:r:RAF activation", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-RNO-5625740:r:RHO GTPases activate PKNs", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-BTA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-9770562:r:mRNA Polyadenylation", "R-BTA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-5625740:r:RHO GTPases activate PKNs", "R-XTR-5625740:r:RHO GTPases activate PKNs", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-5673000:r:RAF activation", "R-BTA-5625740:r:RHO GTPases activate PKNs", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-538898:r:Dephosphorylation of TIM", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-5627123:r:RHO GTPases activate PAKs", "R-MMU-5673000:r:RAF activation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DME-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SCE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CFA-180024:r:DARPP-32 events", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-180024:r:DARPP-32 events", "R-DME-350416:r:Regulation of non-muscle Myosin II", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-BTA-9770562:r:mRNA Polyadenylation", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-BTA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-5673000:r:RAF activation", "R-GGA-5673000:r:RAF activation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9770562:r:mRNA Polyadenylation", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-DDI-9770562:r:mRNA Polyadenylation", "R-BTA-5663220:r:RHO GTPases Activate Formins", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-5625740:r:RHO GTPases activate PKNs", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-GGA-5627123:r:RHO GTPases activate PAKs", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-9770562:r:mRNA Polyadenylation", "R-XTR-5627123:r:RHO GTPases activate PAKs", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CFA-9770562:r:mRNA Polyadenylation", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-180024:r:DARPP-32 events", "R-SSC-5627123:r:RHO GTPases activate PAKs", "R-GGA-9770562:r:mRNA Polyadenylation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-180024:r:DARPP-32 events", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9770562:r:mRNA Polyadenylation", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-DDI-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-68877:r:Mitotic Prometaphase", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-HSA-163560:r:Triglyceride catabolism", "R-XTR-180024:r:DARPP-32 events", "R-BTA-180024:r:DARPP-32 events", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-9770562:r:mRNA Polyadenylation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-9770562:r:mRNA Polyadenylation", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-BTA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Family"}, "IPR050342": {"description": "High Mobility Group Box (HMGB)", "go_ids": [], "go_terms": [], "name": "HMGB", "pathway_ids": ["R-HSA-6798695", "R-HSA-879415", "R-MMU-163282", "R-HSA-2151201", "R-GGA-3000471", "R-SPO-5620971", "R-SCE-140342", "R-SSC-163282", "R-BTA-6798695", "R-DME-163282", "R-HSA-163282", "R-MMU-933542", "R-SSC-140342", "R-SCE-5686938", "R-SPO-5686938", "R-MMU-445989", "R-SPO-163282", "R-BTA-5620971", "R-SCE-5620971", "R-CFA-140342", "R-DDI-5686938", "R-HSA-140342", "R-DDI-6798695", "R-HSA-166058", "R-DDI-163282", "R-CFA-5620971", "R-GGA-5686938", "R-MMU-5686938", "R-GGA-6798695", "R-CFA-879415", "R-BTA-933542", "R-HSA-1236974", "R-HSA-5603041", "R-MMU-6798695", "R-CFA-5686938", "R-HSA-445989", "R-SPO-6798695", "R-MMU-9837999", "R-BTA-140342", "R-BTA-879415", "R-CFA-3000471", "R-HSA-933542", "R-HSA-5620971", "R-SCE-6798695", "R-SCE-163282", "R-DDI-140342", "R-RNO-140342", "R-GGA-140342", "R-HSA-3000471", "R-BTA-445989", "R-DDI-879415", "R-DME-209394", "R-HSA-9837999", "R-HSA-5686938", "R-SPO-140342", "R-BTA-3000471", "R-DDI-9837999", "R-MMU-3000471", "R-DME-9837999", "R-MMU-879415", "R-RNO-9837999", "R-BTA-5686938", "R-CFA-933542", "R-MMU-140342", "R-SPO-9837999", "R-SCE-9837999", "R-CFA-445989", "R-HSA-5602498", "R-MMU-5620971", "R-DME-140342", "R-SSC-9837999", "R-CFA-6798695", "R-RNO-163282", "R-GGA-5620971", "R-DDI-5620971"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-MMU-163282:r:Mitochondrial transcription initiation", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-GGA-3000471:r:Scavenging by Class B Receptors", "R-SPO-5620971:r:Pyroptosis", "R-SCE-140342:r:Apoptosis induced DNA fragmentation", "R-SSC-163282:r:Mitochondrial transcription initiation", "R-BTA-6798695:r:Neutrophil degranulation", "R-DME-163282:r:Mitochondrial transcription initiation", "R-HSA-163282:r:Mitochondrial transcription initiation", "R-MMU-933542:r:TRAF6 mediated NF-kB activation", "R-SSC-140342:r:Apoptosis induced DNA fragmentation", "R-SCE-5686938:r:Regulation of TLR by endogenous ligand", "R-SPO-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SPO-163282:r:Mitochondrial transcription initiation", "R-BTA-5620971:r:Pyroptosis", "R-SCE-5620971:r:Pyroptosis", "R-CFA-140342:r:Apoptosis induced DNA fragmentation", "R-DDI-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-DDI-163282:r:Mitochondrial transcription initiation", "R-CFA-5620971:r:Pyroptosis", "R-GGA-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-GGA-6798695:r:Neutrophil degranulation", "R-CFA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-MMU-6798695:r:Neutrophil degranulation", "R-CFA-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-BTA-140342:r:Apoptosis induced DNA fragmentation", "R-BTA-879415:r:Advanced glycosylation endproduct receptor signaling", "R-CFA-3000471:r:Scavenging by Class B Receptors", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-5620971:r:Pyroptosis", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-163282:r:Mitochondrial transcription initiation", "R-DDI-140342:r:Apoptosis induced DNA fragmentation", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-GGA-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DDI-879415:r:Advanced glycosylation endproduct receptor signaling", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-SPO-140342:r:Apoptosis induced DNA fragmentation", "R-BTA-3000471:r:Scavenging by Class B Receptors", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-DME-9837999:r:Mitochondrial protein degradation", "R-MMU-879415:r:Advanced glycosylation endproduct receptor signaling", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-CFA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CFA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-5602498:r:MyD88 deficiency (TLR2/4)", "R-MMU-5620971:r:Pyroptosis", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-CFA-6798695:r:Neutrophil degranulation", "R-RNO-163282:r:Mitochondrial transcription initiation", "R-GGA-5620971:r:Pyroptosis", "R-DDI-5620971:r:Pyroptosis"], "type": "Family"}, "IPR050343": {"description": "Ribosomal RNA Pseudouridine Synthase RsuA", "go_ids": [], "go_terms": [], "name": "RsuA_PseudoU_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050344": {"description": "Peptidase M1 family aminopeptidases", "go_ids": [], "go_terms": [], "name": "Peptidase_M1_aminopeptidases", "pathway_ids": ["R-SSC-2022377", "R-HSA-6798695", "R-RNO-983170", "R-RNO-1236977", "R-CEL-983170", "R-SCE-6798695", "R-SCE-983170", "R-RNO-2022377", "R-MMU-1236977", "R-HSA-983168", "R-HSA-2022377", "R-CEL-983168", "R-HSA-1236977", "R-BTA-983170", "R-HSA-983170", "R-HSA-1445148", "R-MMU-983170", "R-MMU-983168", "R-SPO-983168", "R-MMU-6798695", "R-SCE-983168", "R-CFA-6798695", "R-RNO-983168", "R-RNO-6798695", "R-MMU-2022377"], "pathways": ["R-SSC-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-1236977:r:Endosomal/Vacuolar pathway", "R-CEL-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-MMU-1236977:r:Endosomal/Vacuolar pathway", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1236977:r:Endosomal/Vacuolar pathway", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CFA-6798695:r:Neutrophil degranulation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Family"}, "IPR050345": {"description": "Aliphatic Amidase/Beta-Ureidopropionase", "go_ids": [], "go_terms": [], "name": "Aliph_Amidase/BUP", "pathway_ids": ["R-DDI-73621", "R-MMU-73621", "R-RNO-73621", "R-HSA-73621"], "pathways": ["R-DDI-73621:r:Pyrimidine catabolism", "R-MMU-73621:r:Pyrimidine catabolism", "R-RNO-73621:r:Pyrimidine catabolism", "R-HSA-73621:r:Pyrimidine catabolism"], "type": "Family"}, "IPR050346": {"description": "Flavin-containing monooxygenases-like", "go_ids": [], "go_terms": [], "name": "FMO-like", "pathway_ids": ["R-MMU-1614558", "R-MMU-217271", "R-CFA-1614558", "R-RNO-1614558", "R-HSA-1614558", "R-SSC-1614558", "R-HSA-5579019", "R-HSA-217271", "R-RNO-217271", "R-CFA-217271", "R-BTA-217271", "R-SSC-217271"], "pathways": ["R-MMU-1614558:r:Degradation of cysteine and homocysteine", "R-MMU-217271:r:FMO oxidises nucleophiles", "R-CFA-1614558:r:Degradation of cysteine and homocysteine", "R-RNO-1614558:r:Degradation of cysteine and homocysteine", "R-HSA-1614558:r:Degradation of cysteine and homocysteine", "R-SSC-1614558:r:Degradation of cysteine and homocysteine", "R-HSA-5579019:r:Defective FMO3 causes TMAU", "R-HSA-217271:r:FMO oxidises nucleophiles", "R-RNO-217271:r:FMO oxidises nucleophiles", "R-CFA-217271:r:FMO oxidises nucleophiles", "R-BTA-217271:r:FMO oxidises nucleophiles", "R-SSC-217271:r:FMO oxidises nucleophiles"], "type": "Family"}, "IPR050347": {"description": "Beta-galactosidase, bacterial-type", "go_ids": [], "go_terms": [], "name": "Bact_Beta-galactosidase", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Family"}, "IPR050348": {"description": "Protein-Tyrosine Phosphatase", "go_ids": [], "go_terms": [], "name": "Protein-Tyr_Phosphatase", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-HSA-449836", "R-SPO-6798695", "R-HSA-182971", "R-RNO-416700", "R-RNO-9851151", "R-MMU-5673001", "R-SCE-6798695", "R-HSA-375165", "R-DDI-5675221", "R-MMU-449836", "R-HSA-5673001", "R-HSA-9008059", "R-HSA-9851151", "R-HSA-202427", "R-HSA-416700", "R-RNO-202427", "R-MMU-202427", "R-MMU-6798695", "R-MMU-9851151", "R-RNO-375165", "R-RNO-5673001", "R-MMU-416700", "R-RNO-449836", "R-RNO-6798695", "R-MMU-375165"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-449836:r:Other interleukin signaling", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-182971:r:EGFR downregulation", "R-RNO-416700:r:Other semaphorin interactions", "R-RNO-9851151:r:MDK and PTN in ALK signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-MMU-449836:r:Other interleukin signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-RNO-375165:r:NCAM signaling for neurite out-growth", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-416700:r:Other semaphorin interactions", "R-RNO-449836:r:Other interleukin signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-375165:r:NCAM signaling for neurite out-growth"], "type": "Family"}, "IPR050349": {"description": "WD repeat LIS1/nudF dynein regulation", "go_ids": [], "go_terms": [], "name": "WD_LIS1/nudF_dynein_reg", "pathway_ids": ["R-DME-983168", "R-DME-202424", "R-DME-1169091", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-DME-8951664", "R-HSA-380284", "R-MMU-68877", "R-RNO-5620912", "R-DME-2565942", "R-MMU-380284", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-HSA-68877", "R-RNO-380284", "R-DME-5607761", "R-DME-5676590", "R-MMU-5620912", "R-HSA-5620912", "R-MMU-9648025", "R-HSA-6811436", "R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-MMU-141444", "R-MMU-380259", "R-RNO-8854518", "R-DME-6811436", "R-HSA-141444", "R-MMU-380270", "R-HSA-380270", "R-HSA-9648025", "R-RNO-5663220", "R-RNO-380259", "R-MMU-6811436", "R-RNO-6811436", "R-DME-69601", "R-MMU-8854518", "R-HSA-5663220", "R-RNO-2467813", "R-RNO-9648025", "R-DME-5607764", "R-HSA-380259", "R-DME-2871837", "R-RNO-380270", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-202424:r:Downstream TCR signaling", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-8951664:r:Neddylation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR050350": {"description": "Complement & Cell Adhesion Regulators", "go_ids": [], "go_terms": [], "name": "Compl-Cell_Adhes-Reg", "pathway_ids": ["R-HSA-6798695", "R-HSA-373080", "R-MMU-977606", "R-DME-202733", "R-HSA-9920588", "R-RNO-198933", "R-DME-6798695", "R-DME-114608", "R-HSA-6807878", "R-DME-373080", "R-SSC-202733", "R-MMU-6807878", "R-MMU-373080", "R-CFA-114608", "R-RNO-114608", "R-RNO-977606", "R-BTA-202733", "R-HSA-114608", "R-MMU-198933", "R-HSA-977606", "R-RNO-202733", "R-MMU-202733", "R-HSA-198933", "R-MMU-6798695", "R-DME-6807878", "R-HSA-202733", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-MMU-977606:r:Regulation of Complement cascade", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-114608:r:Platelet degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-DME-373080:r:Class B/2 (Secretin family receptors)", "R-SSC-202733:r:Cell surface interactions at the vascular wall", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-MMU-373080:r:Class B/2 (Secretin family receptors)", "R-CFA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-977606:r:Regulation of Complement cascade", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-114608:r:Platelet degranulation", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR050351": {"description": "Bacteriophytochrome/Sensor protein kinase WalK/GraS-like", "go_ids": ["GO:0000155"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F"], "name": "BphY/WalK/GraS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050352": {"description": "ATP-binding cassette subfamily G transporters", "go_ids": [], "go_terms": [], "name": "ABCG_transporters", "pathway_ids": ["R-MMU-9753281", "R-RNO-189451", "R-HSA-9725554", "R-RNO-9753281", "R-DDI-1660661", "R-MMU-1369062", "R-HSA-5679096", "R-HSA-1369062", "R-DME-1660661", "R-DDI-189451", "R-HSA-189483", "R-MMU-917937", "R-MMU-189483", "R-RNO-9793528", "R-DME-9753281", "R-DME-917937", "R-HSA-9029569", "R-MMU-8964058", "R-RNO-189483", "R-DDI-1369062", "R-DME-189451", "R-MMU-189451", "R-HSA-8964058", "R-DDI-917937", "R-RNO-917937", "R-HSA-5679090", "R-DME-1369062", "R-DDI-9793528", "R-DDI-8964058", "R-HSA-9753281", "R-HSA-2161517", "R-HSA-1660661", "R-MMU-9793528", "R-HSA-917937", "R-HSA-9818032", "R-RNO-1660661", "R-RNO-1369062", "R-DME-189483", "R-DME-9793528", "R-DDI-189483", "R-HSA-9793528", "R-DDI-9753281", "R-HSA-189451", "R-MMU-1660661"], "pathways": ["R-MMU-9753281:r:Paracetamol ADME", "R-RNO-189451:r:Heme biosynthesis", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-RNO-9753281:r:Paracetamol ADME", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-5679096:r:Defective ABCG5 causes sitosterolemia", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-DME-1660661:r:Sphingolipid de novo biosynthesis", "R-DDI-189451:r:Heme biosynthesis", "R-HSA-189483:r:Heme degradation", "R-MMU-917937:r:Iron uptake and transport", "R-MMU-189483:r:Heme degradation", "R-RNO-9793528:r:Ciprofloxacin ADME", "R-DME-9753281:r:Paracetamol ADME", "R-DME-917937:r:Iron uptake and transport", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-8964058:r:HDL remodeling", "R-RNO-189483:r:Heme degradation", "R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-DME-189451:r:Heme biosynthesis", "R-MMU-189451:r:Heme biosynthesis", "R-HSA-8964058:r:HDL remodeling", "R-DDI-917937:r:Iron uptake and transport", "R-RNO-917937:r:Iron uptake and transport", "R-HSA-5679090:r:Defective ABCG8 causes GBD4 and sitosterolemia", "R-DME-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-9793528:r:Ciprofloxacin ADME", "R-DDI-8964058:r:HDL remodeling", "R-HSA-9753281:r:Paracetamol ADME", "R-HSA-2161517:r:Abacavir transmembrane transport", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-MMU-9793528:r:Ciprofloxacin ADME", "R-HSA-917937:r:Iron uptake and transport", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-DME-189483:r:Heme degradation", "R-DME-9793528:r:Ciprofloxacin ADME", "R-DDI-189483:r:Heme degradation", "R-HSA-9793528:r:Ciprofloxacin ADME", "R-DDI-9753281:r:Paracetamol ADME", "R-HSA-189451:r:Heme biosynthesis", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Family"}, "IPR050354": {"description": "Arabidopsis F-box/kelch-repeat", "go_ids": [], "go_terms": [], "name": "F-box/kelch-repeat_ARATH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050355": {"description": "Mitochondrial Respiratory Supercomplex Factor 1", "go_ids": [], "go_terms": [], "name": "RCF1", "pathway_ids": ["R-HSA-9864848", "R-HSA-611105", "R-HSA-1234158", "R-HSA-9707564", "R-MMU-611105", "R-MMU-5628897", "R-MMU-9864848", "R-HSA-5628897", "R-MMU-9707564"], "pathways": ["R-HSA-9864848:r:Complex IV assembly", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-MMU-611105:r:Respiratory electron 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"R-HSA-2024096:r:HS-GAG degradation", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-MMU-3000157:r:Laminin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-MMU-6794361:r:Neurexins and neuroligins", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DRE-6794361:r:Neurexins and neuroligins", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-2022928:r:HS-GAG biosynthesis", "R-RNO-6794361:r:Neurexins and neuroligins", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Family"}, "IPR050373": {"description": "Fibrinogen C-terminal domain-containing protein", "go_ids": [], "go_terms": [], "name": "Fibrinogen_C-term_domain", "pathway_ids": ["R-HSA-6798695", "R-HSA-9029558", "R-RNO-2855086", "R-HSA-2129379", "R-HSA-8963889", "R-HSA-166662", "R-MMU-6798695", "R-MMU-2855086", "R-HSA-166663", "R-BTA-6798695", "R-BTA-2855086", "R-MMU-8963889", "R-BTA-2129379", "R-HSA-2855086", "R-RNO-6798695", "R-MMU-2129379"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-RNO-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-166662:r:Lectin pathway of complement activation", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-HSA-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-HSA-2855086:r:Ficolins bind to repetitive carbohydrate structures on the target cell surface", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Family"}, "IPR050375": {"description": "Major Facilitator Superfamily TsgA-like", "go_ids": [], "go_terms": [], "name": "MFS_TsgA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050376": {"description": "Pterin-4-alpha-carbinolamine dehydratase", "go_ids": [], "go_terms": [], "name": "Pterin-4-alpha-carb_dehyd", "pathway_ids": ["PWY-7158", "PWY-8099"], "pathways": ["PWY-7158:t:L-phenylalanine degradation V", "PWY-8099:t:tetrahydropteridine recycling"], "type": "Family"}, "IPR050377": {"description": "Radical SAM PqqA peptide cyclase/Mycofactocin maturase MftC-like", "go_ids": [], "go_terms": [], "name": "Radical_SAM_PqqE_MftC-like", "pathway_ids": ["PWY-6420"], "pathways": ["PWY-6420:t:pyrroloquinoline quinone biosynthesis"], "type": "Family"}, "IPR050378": {"description": "Metallo-dependent Hydrolases Superfamily", "go_ids": [], "go_terms": [], "name": "Metallo-dep_Hydrolases_sf", "pathway_ids": ["R-HSA-399956", "R-BTA-399956", "R-MMU-437239", "R-RNO-399956", "R-DDI-73621", "R-RNO-437239", "R-HSA-437239", "R-RNO-73621", "R-HSA-73621", "R-GGA-437239", "R-GGA-399956", "R-DRE-399956", "R-XTR-399956", "R-CEL-399956", "R-MMU-399956", "R-MMU-73621", "R-CEL-73621"], "pathways": ["R-HSA-399956:r:CRMPs in Sema3A signaling", "R-BTA-399956:r:CRMPs in Sema3A signaling", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-399956:r:CRMPs in Sema3A signaling", "R-DDI-73621:r:Pyrimidine catabolism", "R-RNO-437239:r:Recycling pathway of L1", "R-HSA-437239:r:Recycling pathway of L1", "R-RNO-73621:r:Pyrimidine catabolism", "R-HSA-73621:r:Pyrimidine catabolism", "R-GGA-437239:r:Recycling pathway of L1", "R-GGA-399956:r:CRMPs in Sema3A signaling", "R-DRE-399956:r:CRMPs in Sema3A signaling", "R-XTR-399956:r:CRMPs in Sema3A signaling", "R-CEL-399956:r:CRMPs in Sema3A signaling", "R-MMU-399956:r:CRMPs in Sema3A signaling", "R-MMU-73621:r:Pyrimidine catabolism", "R-CEL-73621:r:Pyrimidine catabolism"], "type": "Family"}, "IPR050379": {"description": "Type I Cytokine Receptor", "go_ids": [], "go_terms": [], "name": "Type-I_Cytokine_Rcpt", "pathway_ids": ["R-RNO-1170546", "R-RNO-112411", "R-HSA-8939247", "R-MMU-1170546", "R-HSA-1170546", "R-HSA-1059683", "R-MMU-8984722", "R-CFA-6788467", "R-MMU-112411", "R-HSA-112411", "R-MMU-982772", "R-RNO-1059683", "R-RNO-8984722", "R-RNO-982772", "R-MMU-9020956", "R-HSA-6788467", "R-RNO-9020956", "R-HSA-110056", "R-HSA-982772", "R-MMU-1059683", "R-RNO-110056", "R-SSC-982772", "R-MMU-6788467", "R-SSC-1170546", "R-MMU-110056", "R-RNO-6788467", "R-HSA-9020956", "R-HSA-8984722"], "pathways": ["R-RNO-1170546:r:Prolactin receptor signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-8939247:r:RUNX1 regulates transcription of genes involved in interleukin signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-HSA-1059683:r:Interleukin-6 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-CFA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-1059683:r:Interleukin-6 signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-HSA-982772:r:Growth hormone receptor signaling", "R-MMU-1059683:r:Interleukin-6 signaling", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-SSC-982772:r:Growth hormone receptor signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-1170546:r:Prolactin receptor signaling", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-9020956:r:Interleukin-27 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling"], "type": "Family"}, "IPR050380": {"description": "Immune Recognition and Response Modulators", "go_ids": [], "go_terms": [], "name": "Immune_Resp_Modulators", "pathway_ids": ["R-HSA-173623", "R-HSA-202433", "R-HSA-2871796", "R-HSA-2168880", "R-HSA-2029485", "R-HSA-2029481", "R-MMU-173623", "R-RNO-2029482", "R-MMU-2871796", "R-RNO-977606", "R-HSA-2871837", "R-HSA-2454202", "R-HSA-202427", "R-RNO-2029485", "R-HSA-977606", "R-RNO-173623", "R-MMU-2029485", "R-HSA-2730905", "R-HSA-166663", "R-HSA-202430", "R-MMU-977606", "R-HSA-983695", "R-RNO-2029481", "R-HSA-2871809", "R-HSA-2029482", "R-HSA-9679191", "R-HSA-5690714", "R-HSA-6785807", "R-MMU-5690714", "R-MMU-983695", "R-MMU-2029482", "R-GGA-2132286", "R-MMU-2454202", "R-MMU-2029481", "R-HSA-983170", "R-MMU-2871837", "R-MMU-2871809", "R-HSA-202424", "R-MMU-983170", "R-CFA-983170", "R-HSA-1236974", "R-HSA-198933", "R-MMU-2730905", "R-HSA-9664422", "R-HSA-389948", "R-HSA-9664323", "R-HSA-202733", 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"R-DME-427652", "R-HSA-5619076", "R-CEL-427652", "R-RNO-210500", "R-HSA-442660", "R-MMU-427652", "R-HSA-2672351", "R-CEL-210500", "R-MMU-210500", "R-CEL-4085001", "R-CEL-442660", "R-HSA-5619035", "R-CEL-2160916", "R-MMU-2160916", "R-HSA-2160916", "R-XTR-210500", "R-HSA-428643", "R-CEL-2672351", "R-RNO-442660", "R-BTA-442660", "R-XTR-442660", "R-MMU-2672351", "R-MMU-442660", "R-MMU-4085001", "R-DRE-442660", "R-RNO-4085001", "R-HSA-9662360", "R-DME-2672351", "R-HSA-4085001", "R-RNO-428643", "R-RNO-2160916", "R-HSA-210500", "R-MMU-428643"], "pathways": ["R-RNO-427652:r:Sodium-coupled phosphate cotransporters", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-CEL-428643:r:Organic anion transport by SLC5/17/25 transporters", "R-HSA-427652:r:Sodium-coupled phosphate cotransporters", "R-DME-427652:r:Sodium-coupled phosphate cotransporters", "R-HSA-5619076:r:Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)", "R-CEL-427652:r:Sodium-coupled phosphate cotransporters", 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"R-HSA-9031628:r:NGF-stimulated transcription", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-437239:r:Recycling pathway of L1", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle 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"R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-RNO-6807004:r:Negative regulation of MET activity", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8866376:r:Reelin signalling pathway", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-445355:r:Smooth Muscle Contraction", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins"], "type": "Family"}, "IPR050385": {"description": "Archaeal FAD synthase", "go_ids": [], "go_terms": [], "name": "Archaeal_FAD_synthase", "pathway_ids": ["PWY-6168", "PWY-6167"], "pathways": ["PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Family"}, "IPR050386": {"description": "Glycosyl Hydrolase 5 (Cellulase A)", "go_ids": [], "go_terms": [], "name": "Glycosyl_hydrolase_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050387": {"description": "Hedgehog Signaling", "go_ids": [], "go_terms": [], "name": "Hedgehog_Signaling", "pathway_ids": ["R-HSA-373080", "R-DRE-5358346", "R-MMU-5635838", "R-DME-5362798", "R-GGA-5632681", "R-HSA-9937080", "R-GGA-5358346", "R-RNO-5632681", "R-HSA-5632684", "R-DRE-5362798", "R-DME-5632681", "R-DME-209338", "R-DME-209471", "R-MMU-5632681", "R-HSA-5632681", "R-HSA-5362798", "R-HSA-8941284", "R-MMU-5362798", "R-HSA-5635838", "R-DRE-5632681", "R-MMU-5358346", "R-HSA-9758920", "R-HSA-5362768", "R-HSA-9796292", "R-HSA-5658034", "R-RNO-5362798", "R-GGA-5362798", "R-RNO-5358346", "R-HSA-9690406", "R-DME-5358346", "R-HSA-5358346"], "pathways": ["R-HSA-373080:r:Class B/2 (Secretin family receptors)", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5635838:r:Activation of SMO", "R-DME-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5632681:r:Ligand-receptor interactions", "R-HSA-9937080:r:Developmental Lineage of Multipotent Pancreatic Progenitor Cells", "R-GGA-5358346:r:Hedgehog ligand biogenesis", "R-RNO-5632681:r:Ligand-receptor interactions", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DRE-5362798:r:Release of Hh-Np from the secreting cell", "R-DME-5632681:r:Ligand-receptor interactions", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-MMU-5632681:r:Ligand-receptor interactions", "R-HSA-5632681:r:Ligand-receptor interactions", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation", "R-MMU-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-5635838:r:Activation of SMO", "R-DRE-5632681:r:Ligand-receptor interactions", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9758920:r:Formation of lateral plate mesoderm", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-9796292:r:Formation of axial mesoderm", "R-HSA-5658034:r:HHAT G278V doesn't palmitoylate Hh-Np", "R-RNO-5362798:r:Release of Hh-Np from the secreting cell", "R-GGA-5362798:r:Release of Hh-Np from the secreting cell", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9690406:r:Transcriptional regulation of testis differentiation", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Family"}, "IPR050388": {"description": "ABC Transporter, Nickel and Peptide Import", "go_ids": [], "go_terms": [], "name": "ABC_Ni/Peptide_Import", "pathway_ids": ["R-HSA-9927020", "R-HSA-1222538"], "pathways": ["R-HSA-9927020:r:Heme assimilation", "R-HSA-1222538:r:Tolerance by Mtb to nitric oxide produced by macrophages"], "type": "Family"}, "IPR050389": {"description": "HTH-type transcriptional regulator YidZ/Nodulation protein-like", "go_ids": [], "go_terms": [], "name": "YidZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050390": {"description": "DNA Cytosine-5 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methylation proteins", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-5334118:r:DNA methylation", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling"], "type": "Family"}, "IPR050391": {"description": "Mitochondrial Metabolite Transporter", "go_ids": [], "go_terms": [], "name": "Mito_Metabolite_Transporter", "pathway_ids": ["R-CEL-428643", "R-HSA-9856872", "R-HSA-167826", "R-HSA-1614517", "R-RNO-166187", "R-SCE-1614517", "R-CEL-1614517", "R-BTA-428643", "R-HSA-428643", "R-BTA-166187", "R-CEL-9856872", "R-SCE-428643", "R-BTA-167826", "R-MMU-166187", "R-MMU-1614517", "R-RNO-1614517", "R-HSA-9844594", "R-DDI-428643", "R-SSC-9856872", "R-MMU-167826", "R-DME-167826", "R-HSA-166187", "R-MMU-9856872", "R-DRE-167826", "R-RNO-9856872", "R-SSC-428643", "R-RNO-428643", "R-SSC-167826", "R-RNO-167826", "R-BTA-9856872", "R-DDI-1614517", "R-MMU-428643"], "pathways": ["R-CEL-428643:r:Organic anion transport by SLC5/17/25 transporters", 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"R-HSA-9638771"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)", "R-HSA-9638771:r:Action of antimicrobials"], "type": "Family"}, "IPR050398": {"description": "Heme sensor protein HssS/ArlS-like", "go_ids": ["GO:0000155"], "go_terms": ["GO:0000155:phosphorelay sensor kinase activity:F"], "name": "HssS/ArlS-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050399": {"description": "Phosphocarrier protein HPr", "go_ids": [], "go_terms": [], "name": "HPr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050400": {"description": "Bacterial Cytoskeleton RodZ", "go_ids": [], "go_terms": [], "name": "Bact_Cytoskel_RodZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050401": {"description": "Cyclic nucleotide synthase", "go_ids": [], "go_terms": [], "name": "Cyclic_nucleotide_synthase", "pathway_ids": ["R-HSA-5578768", "R-MMU-5578768", "R-HSA-2514859", "R-MMU-2514859", "R-RNO-5578768", "R-HSA-8942233", "R-RNO-8935690", "R-BTA-5578768", "R-MMU-8935690", "R-HSA-8935690", "R-DDI-2514859", "R-RNO-2514859", "R-SSC-8935690"], "pathways": ["R-HSA-5578768:r:Physiological factors", "R-MMU-5578768:r:Physiological factors", "R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-5578768:r:Physiological factors", "R-HSA-8942233:r:Intestinal infectious diseases", "R-RNO-8935690:r:Digestion", "R-BTA-5578768:r:Physiological factors", "R-MMU-8935690:r:Digestion", "R-HSA-8935690:r:Digestion", "R-DDI-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-SSC-8935690:r:Digestion"], "type": "Family"}, "IPR050402": {"description": "Olfactory receptor 51/52/56-like", "go_ids": [], "go_terms": [], "name": "OR51/52/56-like", "pathway_ids": ["R-HSA-381753", "R-HSA-9752946", "R-MMU-381753"], "pathways": ["R-HSA-381753:r:Olfactory Signaling Pathway", "R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-MMU-381753:r:Olfactory Signaling Pathway"], "type": "Family"}, "IPR050403": {"description": "Myosin regulatory light chain", "go_ids": [], "go_terms": [], "name": "Myosin_RLC", "pathway_ids": ["R-HSA-5625900", "R-HSA-416572", "R-HSA-445355", "R-GGA-445355", "R-RNO-390522", "R-HSA-3928664", "R-HSA-8936459", "R-CEL-3928664", "R-MMU-390522", "R-BTA-3928664", "R-SCE-5627123", "R-HSA-5625740", "R-DME-350480", "R-MMU-445355", "R-DME-445355", "R-RNO-3928664", "R-BTA-5627123", "R-DME-350416", "R-BTA-445355", "R-HSA-3928663", "R-HSA-5627123", "R-RNO-445355", "R-SSC-445355", "R-CEL-445355", "R-SSC-5627123", "R-HSA-390522", "R-SPO-5627123", "R-DME-3928664", "R-DDI-5627123", "R-MMU-5627123", "R-HSA-5627117"], "pathways": ["R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-445355:r:Smooth Muscle Contraction", "R-GGA-445355:r:Smooth Muscle Contraction", "R-RNO-390522:r:Striated Muscle Contraction", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-3928664:r:Ephrin signaling", "R-MMU-390522:r:Striated Muscle Contraction", "R-BTA-3928664:r:Ephrin signaling", "R-SCE-5627123:r:RHO GTPases activate PAKs", "R-HSA-5625740:r:RHO GTPases activate PKNs", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DME-445355:r:Smooth Muscle Contraction", "R-RNO-3928664:r:Ephrin signaling", "R-BTA-5627123:r:RHO GTPases activate PAKs", "R-DME-350416:r:Regulation of non-muscle Myosin II", "R-BTA-445355:r:Smooth Muscle Contraction", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5627123:r:RHO GTPases activate PAKs", "R-RNO-445355:r:Smooth Muscle Contraction", "R-SSC-445355:r:Smooth Muscle Contraction", "R-CEL-445355:r:Smooth Muscle Contraction", "R-SSC-5627123:r:RHO GTPases activate PAKs", "R-HSA-390522:r:Striated Muscle Contraction", "R-SPO-5627123:r:RHO GTPases activate PAKs", "R-DME-3928664:r:Ephrin signaling", "R-DDI-5627123:r:RHO GTPases activate PAKs", "R-MMU-5627123:r:RHO GTPases activate PAKs", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Family"}, "IPR050404": {"description": "Heme-degrading monooxygenase", "go_ids": [], "go_terms": [], "name": "Heme-degrading_MO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050405": {"description": "Intermediate filament structural protein", "go_ids": [], "go_terms": [], "name": "Intermediate_filament", "pathway_ids": ["R-HSA-9646399", "R-HSA-9013422", "R-RNO-9013422", "R-BTA-5673001", "R-HSA-1251985", "R-HSA-9918487", "R-HSA-442982", "R-MMU-9013422", "R-CFA-390522", "R-BTA-438066", "R-SSC-9013422", "R-HSA-9615710", "R-CFA-264870", "R-HSA-9617324", "R-MMU-5673001", "R-HSA-9918481", "R-RNO-5673001", "R-RNO-390522", "R-MMU-438066", "R-HSA-9927432", "R-MMU-390522", "R-HSA-6785807", "R-BTA-264870", "R-RNO-438066", "R-BTA-390522", "R-HSA-5673001", "R-BTA-9013422", "R-SSC-390522", "R-MMU-9646399", "R-HSA-438066", "R-HSA-9620244", "R-CFA-9013422", "R-CFA-9646399", "R-MMU-264870", "R-HSA-390522", "R-HSA-9613829", "R-RNO-9646399", "R-SSC-264870", "R-RNO-264870", "R-BTA-9646399", "R-HSA-264870", "R-HSA-9609736", "R-SSC-9646399"], "pathways": ["R-HSA-9646399:r:Aggrephagy", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-390522:r:Striated Muscle Contraction", "R-BTA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-SSC-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9615710:r:Late endosomal microautophagy", "R-CFA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-390522:r:Striated Muscle Contraction", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-BTA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-BTA-390522:r:Striated Muscle Contraction", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-SSC-390522:r:Striated Muscle Contraction", "R-MMU-9646399:r:Aggrephagy", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9620244:r:Long-term potentiation", "R-CFA-9013422:r:RHOBTB1 GTPase cycle", "R-CFA-9646399:r:Aggrephagy", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-390522:r:Striated Muscle Contraction", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-RNO-9646399:r:Aggrephagy", "R-SSC-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-BTA-9646399:r:Aggrephagy", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-SSC-9646399:r:Aggrephagy"], "type": "Family"}, "IPR050406": {"description": "FGGY Carbohydrate Kinase", "go_ids": [], "go_terms": [], "name": "FGGY_Carb_Kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050407": {"description": "Geranylgeranyl Reductase", "go_ids": [], "go_terms": [], "name": "Geranylgeranyl_reductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050408": {"description": "Hypoxanthine-guanine phosphoribosyltransferase", "go_ids": [], "go_terms": [], "name": "HGPRT", "pathway_ids": ["PWY-6610", "PWY-6609", "PWY-6620", "PWY-6599", "R-MMU-9748787", "R-BTA-74217", "R-HSA-9748787", "R-DDI-74217", "R-DDI-9748787", "R-HSA-9734281", "R-RNO-74217", "R-BTA-9748787", "R-MMU-74217", "R-HSA-74217", "R-SSC-9748787", "R-RNO-9748787", "R-SSC-74217"], "pathways": ["PWY-6610:t:adenine salvage", "PWY-6609:t:adenine and adenosine salvage III", "PWY-6620:t:guanine and guanosine salvage I", "PWY-6599:t:guanine and guanosine salvage II", "R-MMU-9748787:r:Azathioprine ADME", "R-BTA-74217:r:Purine salvage", "R-HSA-9748787:r:Azathioprine ADME", "R-DDI-74217:r:Purine salvage", "R-DDI-9748787:r:Azathioprine ADME", "R-HSA-9734281:r:Defective HPRT1 disrupts guanine and hypoxanthine salvage", "R-RNO-74217:r:Purine salvage", "R-BTA-9748787:r:Azathioprine ADME", "R-MMU-74217:r:Purine salvage", "R-HSA-74217:r:Purine salvage", "R-SSC-9748787:r:Azathioprine ADME", "R-RNO-9748787:r:Azathioprine ADME", "R-SSC-74217:r:Purine salvage"], "type": "Family"}, "IPR050409": {"description": "E3 ubiquitin-protein ligase", "go_ids": [], "go_terms": [], "name": "E3_ubiq-protein_ligase", "pathway_ids": ["PWY-7511", "R-MMU-2173795", "R-BTA-983168", "R-HSA-9013409", "R-HSA-6798695", "R-MMU-5632684", "R-RNO-8948751", "R-HSA-168638", "R-MMU-8941858", "R-CEL-1253288", "R-HSA-5689880", "R-DME-2173788", "R-MMU-2173791", "R-MMU-2122948", "R-MMU-8948751", "R-DME-8948751", "R-DRE-8941858", "R-MMU-5689880", "R-MMU-9013420", "R-HSA-4641257", "R-DME-8948747", "R-SCE-9013420", "R-HSA-9013507", "R-DME-4608870", "R-DRE-201451", "R-DME-4641257", "R-CEL-4641258", "R-HSA-5675482", "R-HSA-8941858", "R-MMU-8948747", "R-DME-1253288", "R-HSA-162588", "R-HSA-4641258", "R-DME-2173791", "R-MMU-4641258", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-9013406", "R-HSA-1253288", "R-HSA-8948751", "R-MMU-6798695", "R-CEL-8948751", "R-MMU-2173788", "R-DRE-4608870", "R-RNO-983168", "R-DME-201451", "R-RNO-6798695", "R-DME-8941858", "R-DME-2122948", "R-GGA-983168", "R-SPO-6798695", "R-MMU-5610780", "R-DME-983168", "R-HSA-2122948", "R-RNO-1169408", "R-SCE-6798695", "R-HSA-2672351", "R-HSA-201451", "R-HSA-936440", "R-DRE-4641257", "R-HSA-1169408", "R-CEL-983168", "R-RNO-1253288", "R-DRE-983168", "R-SPO-9013406", "R-MMU-8939236", "R-SCE-9013406", "R-MMU-2672351", "R-MMU-9013507", "R-HSA-2173795", "R-DME-9013406", "R-MMU-201451", "R-SPO-983168", "R-SPO-9013420", "R-CEL-9013406", "R-MMU-168638", "R-SCE-983168", "R-MMU-4608870", "R-RNO-8948747", "R-DRE-5689880", "R-HSA-5610780", "R-HSA-9013420", "R-HSA-8948747", "R-HSA-2173791", "R-MMU-5675482", "R-DRE-2173788", "R-DME-8939236", "R-DME-2173795", "R-HSA-983168", "R-MMU-1169408", "R-HSA-5632684", "R-HSA-8939902", "R-CEL-2672351", "R-DME-5632684", "R-HSA-9692916", "R-MMU-983168", "R-CEL-9013420", "R-HSA-9013406", "R-HSA-2173788", "R-HSA-8939236", "R-DME-5689880", "R-DME-9013420", "R-MMU-1253288"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-DRE-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-4641257:r:Degradation of AXIN", "R-DME-8948747:r:Regulation of PTEN localization", "R-SCE-9013420:r:RHOU GTPase cycle", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-DRE-201451:r:Signaling by BMP", "R-DME-4641257:r:Degradation of AXIN", "R-CEL-4641258:r:Degradation of DVL", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8948747:r:Regulation of PTEN localization", "R-DME-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-162588:r:Budding and maturation of HIV virion", "R-HSA-4641258:r:Degradation of DVL", "R-DME-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-4641258:r:Degradation of DVL", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-1253288:r:Downregulation of ERBB4 signaling", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DRE-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-201451:r:Signaling by BMP", "R-RNO-6798695:r:Neutrophil degranulation", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-GGA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-201451:r:Signaling by BMP", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-DRE-4641257:r:Degradation of AXIN", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-1253288:r:Downregulation of ERBB4 signaling", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SCE-9013406:r:RHOQ GTPase cycle", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-9013406:r:RHOQ GTPase cycle", "R-MMU-201451:r:Signaling by BMP", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-9013420:r:RHOU GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-RNO-8948747:r:Regulation of PTEN localization", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DRE-2173788:r:Downregulation of TGF-beta receptor signaling", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-5632684:r:Hedgehog 'on' state", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-2672351:r:Stimuli-sensing channels", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-9013420:r:RHOU GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle", "R-MMU-1253288:r:Downregulation of ERBB4 signaling"], "type": "Family"}, "IPR050410": {"description": "CCR4/nocturin mRNA turnover and transcription", "go_ids": [], "go_terms": [], "name": "CCR4/nocturin_mRNA_transcr", "pathway_ids": ["R-HSA-5617472", "R-HSA-8983711", "R-HSA-6804115", "R-RNO-8983711", "R-MMU-429947", "R-HSA-429947", "R-HSA-9820841", "R-BTA-8983711", "R-MMU-6804115", "R-DRE-6804115", "R-HSA-1368108", "R-MMU-8983711", "R-RNO-6804115"], "pathways": ["R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-8983711:r:OAS antiviral response", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-RNO-8983711:r:OAS antiviral response", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-BTA-8983711:r:OAS antiviral response", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-MMU-8983711:r:OAS antiviral response", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Family"}, "IPR050411": {"description": "Alpha-ketoglutarate-dependent hydroxylases", "go_ids": [], "go_terms": [], "name": "AlphaKG_dependent_hydroxylases", "pathway_ids": ["R-RNO-71262", "R-MMU-71262", "R-GGA-71262", "R-SCE-71262", "R-CEL-71262", "R-HSA-71262", "R-BTA-71262"], "pathways": ["R-RNO-71262:r:Carnitine synthesis", "R-MMU-71262:r:Carnitine synthesis", "R-GGA-71262:r:Carnitine synthesis", "R-SCE-71262:r:Carnitine synthesis", "R-CEL-71262:r:Carnitine synthesis", "R-HSA-71262:r:Carnitine synthesis", "R-BTA-71262:r:Carnitine synthesis"], "type": "Family"}, "IPR050412": {"description": "Immunoglobulin-like Receptors in Immune Regulation", "go_ids": [], "go_terms": [], "name": "Ig-like_Receptors_ImmuneReg", "pathway_ids": ["R-HSA-6798695", "R-HSA-114608", "R-BTA-114608", "R-HSA-75892", "R-MMU-198933", "R-RNO-198933", "R-HSA-114604", "R-MMU-114604", "R-MMU-75892", "R-HSA-2172127", "R-MMU-6798695", "R-HSA-198933", "R-BTA-6798695", "R-HSA-202733", "R-RNO-6798695", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-75892:r:Platelet Adhesion to exposed collagen", "R-HSA-2172127:r:DAP12 interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR050413": {"description": "T cell receptor beta variable", "go_ids": [], "go_terms": [], "name": "TCR_beta_variable", "pathway_ids": ["R-HSA-198933", "R-HSA-202427", "R-HSA-389948", "R-HSA-202430", "R-HSA-202424", "R-HSA-202433"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-202433:r:Generation of second messenger molecules"], "type": "Family"}, "IPR050414": {"description": "Peptidase M35", "go_ids": [], "go_terms": [], "name": "M35", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050415": {"description": "Multicomponent Reductase Electron Transfer", "go_ids": [], "go_terms": [], "name": "MRET", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050416": {"description": "FAD-linked Oxidoreductases in Biosynthetic Pathways", "go_ids": [], "go_terms": [], "name": "FAD-linked_Oxidoreductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050417": {"description": "Sugar Epimerase/Isomerase", "go_ids": [], "go_terms": [], "name": "Sugar_Epim/Isomerase", "pathway_ids": ["PWY-6961"], "pathways": ["PWY-6961:t:L-ascorbate degradation II (bacterial, aerobic)"], "type": "Family"}, "IPR050418": {"description": "D-isomer specific 2-hydroxyacid dehydrogenase, PdxB subfamily", "go_ids": [], "go_terms": [], "name": 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"go_ids": [], "go_terms": [], "name": "UPF0337_stress_rsp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050424": {"description": "Gfo/Idh/MocA family inositol dehydrogenases", "go_ids": [], "go_terms": [], "name": "Gfo-Idh-MocA_inositol_DH", "pathway_ids": ["PWY-7237", "PWY-5940", "PWY-7241"], "pathways": ["PWY-7237:t:myo-, chiro- and scyllo-inositol degradation", "PWY-5940:t:streptomycin biosynthesis", "PWY-7241:t:myo-inositol degradation II"], "type": "Family"}, "IPR050425": {"description": "NAD(P)-dependent dehydratase-like", "go_ids": [], "go_terms": [], "name": "NAD(P)_dehydrat-like", "pathway_ids": ["R-RNO-193807", "R-RNO-193775", "R-HSA-193775", "R-MMU-193368", "R-MMU-193775", "R-RNO-193368", "R-HSA-193368", "R-HSA-193807", "R-MMU-193807"], "pathways": ["R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-RNO-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-HSA-193775:r:Synthesis of bile acids and bile 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"R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-MMU-381753:r:Olfactory Signaling Pathway"], "type": "Family"}, "IPR050428": {"description": "Two-component system sensor histidine kinase", "go_ids": ["GO:0000160"], "go_terms": ["GO:0000160:phosphorelay signal transduction system:P"], "name": "TCS_sensor_his_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050429": {"description": "Phosphotransferase System Glucose-Specific EIICBA", "go_ids": [], "go_terms": [], "name": "PTS_Glucose_EIICBA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050431": {"description": "Adaptor complexes medium subunit", "go_ids": [], "go_terms": [], "name": "Adaptor_comp_med_subunit", "pathway_ids": ["R-RNO-5140745", "R-MMU-8856828", "R-HSA-6798695", "R-SPO-437239", "R-BTA-196025", "R-SCE-8856828", "R-DRE-8964038", "R-XTR-8856825", "R-HSA-8856828", "R-CEL-6798695", "R-CEL-5099900", "R-MMU-5099900", "R-HSA-9918485", "R-CEL-432722", "R-BTA-6798695", "R-RNO-8964038", "R-BTA-190873", "R-DDI-8856825", "R-GGA-437239", "R-GGA-8964038", "R-HSA-196025", "R-RNO-196025", "R-SPO-8856825", "R-XTR-5099900", "R-RNO-177504", "R-DDI-8856828", "R-DDI-8964038", "R-HSA-5140745", "R-XTR-5140745", "R-GGA-196025", "R-XTR-8866427", "R-RNO-8866427", "R-GGA-5140745", "R-GGA-8856828", "R-RNO-432722", "R-DDI-6798695", "R-MMU-196025", "R-BTA-5099900", "R-RNO-432720", "R-DRE-416993", "R-HSA-432720", "R-HSA-437239", "R-CEL-8866427", "R-MMU-5140745", "R-BTA-177504", "R-HSA-164939", "R-HSA-164940", "R-GGA-416993", "R-MMU-8866427", "R-CEL-8964038", "R-SPO-8866427", "R-SPO-190873", "R-SCE-8856825", "R-MMU-6798695", "R-SCE-196025", "R-SPO-196025", "R-CEL-8856825", "R-SCE-8866427", "R-RNO-6798695", "R-XTR-437239", "R-DRE-196025", "R-HSA-2132295", "R-SPO-6798695", "R-MMU-8856825", "R-HSA-190873", "R-CEL-432720", "R-MMU-432722", "R-CEL-437239", "R-CEL-190873", "R-DDI-437239", "R-SCE-6798695", "R-BTA-416993", "R-SPO-8964038", "R-MMU-190873", "R-CEL-5140745", 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"R-HSA-196025:r:Formation of annular gap junctions", "R-RNO-196025:r:Formation of annular gap junctions", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-XTR-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-DDI-8964038:r:LDL clearance", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-XTR-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-GGA-196025:r:Formation of annular gap junctions", "R-XTR-8866427:r:VLDLR internalisation and degradation", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-GGA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-196025:r:Formation of annular gap junctions", "R-BTA-5099900:r:WNT5A-dependent 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endocytosis", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-2132295:r:MHC class II antigen presentation", "R-MMU-437239:r:Recycling pathway of L1", "R-XTR-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-437239:r:Recycling pathway of L1", "R-XTR-196025:r:Formation of annular gap junctions", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-196025:r:Formation of annular gap junctions", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-DRE-177504:r:Retrograde neurotrophin signalling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-GGA-190873:r:Gap junction degradation", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-GGA-2132295:r:MHC class II antigen presentation", "R-GGA-177504:r:Retrograde neurotrophin signalling", "R-BTA-8964038:r:LDL clearance", "R-GGA-8866427:r:VLDLR internalisation and degradation", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-GGA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-SCE-437239:r:Recycling pathway of L1", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-XTR-8964038:r:LDL clearance", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-190873:r:Gap junction degradation", "R-HSA-8964038:r:LDL clearance", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Family"}, "IPR050432": {"description": "FAD-linked Oxidoreductases in Biosynthesis Pathways", "go_ids": [], "go_terms": [], "name": "FAD-linked_Oxidoreductases_BP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050433": {"description": "Myc family transcription factors", "go_ids": [], "go_terms": [], "name": "Myc_transcription_factors", "pathway_ids": ["R-HSA-8866911", "R-RNO-8866911", "R-HSA-9839394", "R-HSA-8951430", "R-DME-8866911", "R-BTA-5689880", "R-BTA-8866911", "R-HSA-5689880", "R-HSA-69202", "R-HSA-2894862", "R-HSA-9818749", "R-HSA-6785807", "R-GGA-8866911", "R-RNO-5689880", "R-HSA-9764562", "R-GGA-5689880", "R-MMU-5689880", "R-HSA-9909649", "R-HSA-69656", "R-MMU-8866911", "R-HSA-5687128", "R-HSA-1362277", "R-HSA-201556", "R-HSA-9616222", "R-HSA-4411364", "R-HSA-2644606", "R-DRE-8866911", "R-HSA-2122947", "R-HSA-2173796", "R-HSA-9018519"], "pathways": ["R-HSA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-RNO-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-9839394:r:TGFBR3 expression", "R-HSA-8951430:r:RUNX3 regulates WNT signaling", "R-DME-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9764562:r:Regulation of CDH1 mRNA translation by microRNAs", "R-GGA-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-HSA-201556:r:Signaling by ALK", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-4411364:r:Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-DRE-8866911:r:TFAP2 (AP-2) family regulates transcription of cell cycle factors", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 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"PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-DDI-75105", "R-DDI-199220"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Family"}, "IPR050445": {"description": "Bacterial polysaccharide biosynthesis and export", "go_ids": [], "go_terms": [], "name": "Bact_polysacc_biosynth/exp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050446": {"description": "FAD-dependent Oxidoreductases and Apoptosis Regulators", "go_ids": [], "go_terms": [], "name": "FAD-oxidoreductase/Apoptosis", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050447": {"description": "Erg6/SMT methyltransferase", "go_ids": [], "go_terms": [], "name": "Erg6_SMT_methyltransf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050448": {"description": "OpgB/LTA synthase bacterial cell wall biosynthesis", "go_ids": [], "go_terms": [], "name": "OpgB/LTA_synthase_biosynth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050449": {"description": "Ephrin receptor tyrosine kinases", "go_ids": [], "go_terms": [], "name": "Ephrin_rcpt_TKs", "pathway_ids": ["R-CEL-3928664", "R-MMU-3928665", "R-DRE-3928662", "R-MMU-9013408", "R-CEL-9013424", "R-HSA-9013424", "R-MMU-9013404", "R-HSA-9824272", "R-HSA-373760", "R-HSA-3928662", "R-CEL-9013149", "R-DRE-3928664", "R-HSA-9013423", "R-MMU-9013420", "R-CEL-3928663", "R-RNO-3928665", "R-RNO-3928662", "R-HSA-2682334", "R-HSA-9696273", "R-HSA-9013408", "R-CEL-3928662", "R-MMU-3928664", "R-CEL-9013423", "R-DRE-2682334", "R-HSA-9013420", "R-HSA-3928664", "R-HSA-9696270", "R-RNO-2682334", "R-MMU-9013424", "R-MMU-2682334", "R-RNO-3928663", "R-MMU-3928663", "R-RNO-3928664", "R-CEL-3928665", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-HSA-3928663", "R-HSA-3928665", "R-CEL-2682334", "R-MMU-3928662", "R-CEL-9013420", "R-DRE-3928665", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-2892247", "R-MMU-9696273", "R-MMU-9013149", "R-DRE-3928663"], "pathways": ["R-CEL-3928664:r:Ephrin signaling", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DRE-3928662:r:EPHB-mediated forward signaling", "R-MMU-9013408:r:RHOG GTPase cycle", "R-CEL-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9824272:r:Somitogenesis", "R-HSA-373760:r:L1CAM interactions", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-DRE-3928664:r:Ephrin signaling", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928665:r:EPH-ephrin mediated repulsion of cells", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-HSA-2682334:r:EPH-Ephrin signaling", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-MMU-3928664:r:Ephrin signaling", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-DRE-2682334:r:EPH-Ephrin signaling", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-2682334:r:EPH-Ephrin signaling", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-2682334:r:EPH-Ephrin signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-RNO-3928664:r:Ephrin signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-DRE-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DRE-3928663:r:EPHA-mediated growth cone collapse"], "type": "Family"}, "IPR050450": {"description": "COX15/CtaA Heme A synthase, prokaryotes", "go_ids": [], "go_terms": [], "name": "HemeA_synthase_prok", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050452": {"description": "Metacaspase", "go_ids": [], "go_terms": [], "name": "Metacaspase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050453": {"description": "LIM/homeobox transcription factors", "go_ids": [], "go_terms": [], "name": "LIM_Homeobox_TF", "pathway_ids": ["R-HSA-9761174", "R-HSA-9831926", "R-HSA-9752946", "R-HSA-9830364", "R-HSA-9010553"], "pathways": ["R-HSA-9761174:r:Formation of intermediate mesoderm", "R-HSA-9831926:r:Nephron development", "R-HSA-9752946:r:Expression and translocation of olfactory receptors", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs"], "type": "Family"}, "IPR050454": {"description": "RTT106/SSRP1 Histone Chaperone/FACT Complex", "go_ids": [], "go_terms": [], "name": "RTT106/SSRP1_HistChap/FACT", "pathway_ids": ["R-SPO-674695", "R-RNO-674695", "R-HSA-167238", "R-MMU-6804756", "R-DME-6796648", "R-SCE-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-DDI-674695", "R-HSA-167152", "R-DDI-6796648", "R-DDI-6804756", "R-CEL-6804756", "R-RNO-6804756", "R-SPO-6796648", "R-SCE-6796648", "R-CEL-75955", "R-MMU-6796648", "R-DME-674695", "R-RNO-6796648", "R-HSA-167243", "R-RNO-75955", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-DME-112382", "R-HSA-167200", "R-HSA-6804756", "R-HSA-167290", "R-RNO-112382", "R-CEL-112382", "R-HSA-75955", "R-SCE-674695", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", 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"PWY-5821", "PWY-6749", "PWY-7056", "PWY-7256", "R-MMU-9013406", "R-HSA-9013406", "R-XTR-9013406"], "pathways": ["PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6848:t:rutin degradation", "PWY-7134:t:rutin degradation (plants)", "PWY-8435:t:yeast mannan degradation", "PWY-1921:t:indole-3-acetate activation II", "PWY-7133:t:quercetin glucoside degradation (Allium)", "PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)", "PWY-8436:t:mammalian high-mannose N-glycan degradation", "PWY-7091:t:linustatin bioactivation", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-6527:t:stachyose degradation", "PWY-6717:t:(1,4)-beta-D-xylan degradation", "PWY-7647:t:ulvan degradation", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8366:t:septacidin biosynthesis", "PWY-5976:t:dhurrin degradation", "PWY-6821:t:kappa-carrageenan degradation", "PWY-6735:t:starch degradation IV", "PWY-6906:t:chitin derivatives degradation", "PWY-6855:t:chitin 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"R-SCE-189451:r:Heme biosynthesis", "R-SPO-189451:r:Heme biosynthesis", "R-HSA-189451:r:Heme biosynthesis"], "type": "Family"}, "IPR050465": {"description": "UPF0194 membrane-associated transport protein", "go_ids": [], "go_terms": [], "name": "UPF0194_transport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050466": {"description": "Carboxylesterases/Gibberellin receptors", "go_ids": [], "go_terms": [], "name": "Carboxylest/Gibb_receptor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050467": {"description": "Leucine-rich repeat and fibronectin type-III domain-containing", "go_ids": [], "go_terms": [], "name": "LRFN", "pathway_ids": ["R-HSA-6798695", "R-HSA-9725554", "R-HSA-9845620", "R-MMU-8849932", "R-HSA-140837", "R-HSA-430116", "R-MMU-6794361", "R-BTA-8849932", "R-HSA-8849932", "R-HSA-6807004", "R-HSA-6794361", "R-DRE-8849932", "R-HSA-75892", "R-BTA-114608", "R-HSA-76009", "R-HSA-9673221", "R-BTA-6794361", "R-HSA-9846298", "R-HSA-177929", "R-MMU-6807004", "R-RNO-6794361", "R-RNO-8849932", "R-MMU-177929"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-MMU-8849932:r:Synaptic adhesion-like molecules", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-MMU-6794361:r:Neurexins and neuroligins", "R-BTA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-8849932:r:Synaptic adhesion-like molecules", "R-HSA-6807004:r:Negative regulation of MET activity", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DRE-8849932:r:Synaptic adhesion-like molecules", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-BTA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-9673221:r:Defective F9 activation", "R-BTA-6794361:r:Neurexins and neuroligins", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-6807004:r:Negative regulation of MET activity", "R-RNO-6794361:r:Neurexins and neuroligins", "R-RNO-8849932:r:Synaptic adhesion-like molecules", "R-MMU-177929:r:Signaling by EGFR"], "type": "Family"}, "IPR050468": {"description": "Larval/pupal cuticle protein", "go_ids": [], "go_terms": [], "name": "Cuticle_Struct_Prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050469": {"description": "Diguanylate cyclase Dgc-like, bacteria", "go_ids": [], "go_terms": [], "name": "Diguanylate_Cyclase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050471": {"description": "AB hydrolase", "go_ids": [], "go_terms": [], "name": "AB_hydrolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050472": {"description": "Anthranilate Synthase/Amidotransferase", "go_ids": [], "go_terms": [], "name": "Anth_synth/Amidotransfase", "pathway_ids": ["PWY-7400", "PWY-7791", "PWY-5686", "PWY-7790", "PWY-5154"], "pathways": ["PWY-7400:t:L-arginine biosynthesis IV (archaea)", "PWY-7791:t:UMP biosynthesis III", "PWY-5686:t:UMP biosynthesis I", "PWY-7790:t:UMP biosynthesis II", "PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "type": "Family"}, "IPR050473": {"description": "Alpha-2-macroglobulin/Complement system", "go_ids": [], "go_terms": [], "name": "A2M/Complement_sys", "pathway_ids": ["R-RNO-166663", "R-HSA-6798695", "R-MMU-163125", "R-HSA-9920588", "R-HSA-375276", "R-BTA-173736", "R-RNO-1474228", "R-HSA-140837", "R-MMU-166663", "R-BTA-6798695", "R-MMU-375276", "R-MMU-166665", "R-MMU-8957275", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-RNO-977606", "R-RNO-140837", "R-BTA-8957275", "R-HSA-114608", "R-BTA-418594", "R-HSA-166665", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-BTA-381426", "R-HSA-174577", "R-HSA-166663", "R-HSA-381426", "R-BTA-977606", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-8963896", "R-MMU-977606", "R-BTA-198933", "R-RNO-198933", "R-HSA-9660826", "R-MMU-140837", "R-BTA-174577", "R-RNO-174577", "R-MMU-173736", "R-RNO-381426", "R-RNO-8963896", "R-MMU-8963896", "R-HSA-163125", "R-HSA-418594", "R-MMU-198933", "R-RNO-166665", "R-RNO-375276", "R-HSA-173736", "R-RNO-173736", "R-HSA-198933", "R-HSA-8957275", "R-MMU-6798695", "R-RNO-6798695", "R-BTA-375276", "R-MMU-114608"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-173736:r:Alternative complement activation", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-166663:r:Initial triggering of complement", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-166665:r:Terminal pathway of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-166665:r:Terminal pathway of complement", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-977606:r:Regulation of Complement cascade", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-8963896:r:HDL assembly", "R-MMU-977606:r:Regulation of Complement cascade", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-174577:r:Activation of C3 and C5", "R-RNO-174577:r:Activation of C3 and C5", "R-MMU-173736:r:Alternative complement activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8963896:r:HDL assembly", "R-MMU-8963896:r:HDL assembly", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-418594:r:G alpha (i) signalling events", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-166665:r:Terminal pathway of complement", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-173736:r:Alternative complement activation", "R-RNO-173736:r:Alternative complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR050474": {"description": "Helicase Hel308/SKI2-like", "go_ids": [], "go_terms": [], "name": "Hel308_SKI2-like", "pathway_ids": ["R-HSA-9954716", "R-BTA-9954716", "R-CEL-72165", "R-MMU-72163", "R-DME-72163", "R-RNO-72163", "R-DDI-72163", "R-GGA-9954716", "R-HSA-72163", "R-MMU-9954716", "R-HSA-112126", "R-RNO-9954716", "R-DME-72165", "R-MMU-72165", "R-RNO-72165", "R-HSA-72165", "R-CEL-72163", "R-SPO-72163", "R-HSA-9918481", "R-DDI-9954716"], "pathways": ["R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-GGA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-112126:r:ALKBH3 mediated reversal of alkylation damage", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "type": "Family"}, "IPR050475": {"description": "Prenyltransferase/isoprenoid biosynthesis", "go_ids": [], "go_terms": [], "name": "Prenyltransferase_related", "pathway_ids": ["PWY-6349"], "pathways": ["PWY-6349:t:C20,20 CDP-archaeol biosynthesis"], "type": "Family"}, "IPR050476": {"description": "Insect Cytochrome P450 Detoxification", "go_ids": [], "go_terms": [], "name": "Insect_CytP450_Detox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050477": {"description": "Group II Amino Acid Decarboxylases", "go_ids": [], "go_terms": [], "name": "GrpII_AminoAcid_Decarb", "pathway_ids": ["R-SCE-9845614", "R-MMU-9845614", "R-HSA-9845614", "R-RNO-9845614", "R-DME-9845614", "R-CEL-9845614", "R-DDI-9845614"], "pathways": ["R-SCE-9845614:r:Sphingolipid catabolism", "R-MMU-9845614:r:Sphingolipid catabolism", "R-HSA-9845614:r:Sphingolipid catabolism", "R-RNO-9845614:r:Sphingolipid catabolism", "R-DME-9845614:r:Sphingolipid catabolism", "R-CEL-9845614:r:Sphingolipid catabolism", "R-DDI-9845614:r:Sphingolipid catabolism"], "type": "Family"}, "IPR050478": {"description": "Ethylene and sulfur compound biosynthesis-related protein", "go_ids": [], "go_terms": [], "name": "Ethylene_sulfur-biosynth", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050479": {"description": "Cytochrome P450, families 11 and 27", "go_ids": [], "go_terms": [], "name": "CYP11_CYP27_families", "pathway_ids": ["R-RNO-193807", "R-DME-211976", "R-MMU-193775", "R-DME-211916", "R-RNO-193993", "R-HSA-193368", "R-RNO-211916", "R-SSC-211976", "R-HSA-5579009", "R-CEL-196791", "R-MMU-196108", "R-HSA-196791", "R-DME-196791", "R-HSA-5579017", "R-HSA-193993", "R-MMU-194002", "R-CEL-193144", "R-HSA-5578996", "R-SSC-196108", "R-HSA-211916", "R-HSA-5579014", "R-HSA-196108", "R-CEL-211976", "R-HSA-193775", "R-MMU-193368", "R-DME-193144", "R-HSA-5579026", "R-CEL-211916", "R-HSA-5579010", "R-RNO-194002", "R-HSA-193807", "R-RNO-196108", "R-MMU-193993", "R-RNO-196791", "R-RNO-193775", "R-MMU-211976", "R-MMU-196791", "R-RNO-211976", "R-RNO-193368", "R-MMU-211916", "R-HSA-211976", "R-MMU-193807", "R-HSA-194002"], "pathways": ["R-RNO-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-DME-211976:r:Endogenous sterols", "R-MMU-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-DME-211916:r:Vitamins", "R-RNO-193993:r:Mineralocorticoid biosynthesis", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-211916:r:Vitamins", "R-SSC-211976:r:Endogenous sterols", "R-HSA-5579009:r:Defective CYP11B2 causes CMO-1 deficiency", "R-CEL-196791:r:Vitamin D (calciferol) metabolism", "R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-DME-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-5579017:r:Defective CYP11B1 causes AH4", "R-HSA-193993:r:Mineralocorticoid biosynthesis", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-CEL-193144:r:Estrogen biosynthesis", "R-HSA-5578996:r:Defective CYP27A1 causes CTX", "R-SSC-196108:r:Pregnenolone biosynthesis", "R-HSA-211916:r:Vitamins", "R-HSA-5579014:r:Defective CYP27B1 causes VDDR1A", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-CEL-211976:r:Endogenous sterols", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DME-193144:r:Estrogen biosynthesis", "R-HSA-5579026:r:Defective CYP11A1 causes AICSR", "R-CEL-211916:r:Vitamins", "R-HSA-5579010:r:Defective CYP24A1 causes HCAI", "R-RNO-194002:r:Glucocorticoid biosynthesis", "R-HSA-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-MMU-193993:r:Mineralocorticoid biosynthesis", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-MMU-211976:r:Endogenous sterols", "R-MMU-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-211976:r:Endogenous sterols", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-211916:r:Vitamins", "R-HSA-211976:r:Endogenous sterols", "R-MMU-193807:r:Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "R-HSA-194002:r:Glucocorticoid biosynthesis"], "type": "Family"}, "IPR050480": {"description": "Sulfate transporter CysZ-like", "go_ids": [], "go_terms": [], "name": "CysZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050481": {"description": "UDP-glycosyltransferase, plant-type", "go_ids": ["GO:0035251"], "go_terms": ["GO:0035251:UDP-glucosyltransferase activity:F"], "name": "UDP-glycosyltransf_plant", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050482": {"description": "Sensor Histidine Kinase Two-Component System", "go_ids": [], "go_terms": [], "name": "Sensor_HK_TwoCompSys", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050483": {"description": "CoA-transferase III domain-containing protein", "go_ids": [], "go_terms": [], "name": "CoA-transferase_III_domain", "pathway_ids": ["PWY-6695"], "pathways": ["PWY-6695:t:oxalate degradation II"], "type": "Family"}, "IPR050484": {"description": "Transferase Hexapeptide/Carbonic Anhydrase", "go_ids": [], "go_terms": [], "name": "Transf_Hexapept/Carb_Anhydrase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050485": {"description": "Proline metabolism enzyme", "go_ids": [], "go_terms": [], "name": "Proline_metab_enzyme", "pathway_ids": ["PWY-6853"], "pathways": ["PWY-6853:t:ethene biosynthesis II (microbes)"], "type": "Family"}, "IPR050486": {"description": "Mannose-1-phosphate guanyltransferase", "go_ids": [], "go_terms": [], "name": "Mannose-1P_guanyltransferase", "pathway_ids": ["PWY-5659", "R-HSA-446205", "R-RNO-446205", "R-SPO-446205", "R-DME-446205", "R-DDI-446205", "R-XTR-446205", "R-MMU-446205", "R-CEL-446205", "R-DRE-446205"], "pathways": ["PWY-5659:t:GDP-mannose biosynthesis", "R-HSA-446205:r:Synthesis of GDP-mannose", "R-RNO-446205:r:Synthesis of GDP-mannose", "R-SPO-446205:r:Synthesis of GDP-mannose", "R-DME-446205:r:Synthesis of GDP-mannose", "R-DDI-446205:r:Synthesis of GDP-mannose", "R-XTR-446205:r:Synthesis of GDP-mannose", "R-MMU-446205:r:Synthesis of GDP-mannose", "R-CEL-446205:r:Synthesis of GDP-mannose", "R-DRE-446205:r:Synthesis of GDP-mannose"], "type": "Family"}, "IPR050487": {"description": "Bacterial Cell Division FtsQ/DivIB", "go_ids": [], "go_terms": [], "name": "FtsQ_DivIB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050488": {"description": "Immunoglobulin Fc region receptor", "go_ids": [], "go_terms": [], "name": "Ig_Fc_receptor", "pathway_ids": ["R-HSA-6798695", "R-MMU-163125", "R-SSC-6798695", "R-RNO-216083", "R-HSA-2871796", "R-SSC-114608", "R-HSA-432142", "R-HSA-2029485", "R-MMU-210990", "R-BTA-6798695", "R-HSA-2029481", "R-SSC-202733", "R-RNO-2871809", "R-MMU-432142", "R-RNO-114608", "R-MMU-2871796", "R-RNO-2029482", 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[], "name": "FAD-dep_Monooxygenase_BioMet", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050494": {"description": "Serine/threonine and dual-specificity kinase", "go_ids": [], "go_terms": [], "name": "Ser_Thr_dual-spec_kinase", "pathway_ids": ["R-HSA-2032785", "R-HSA-9022692", "R-MMU-3899300", "R-MMU-72163", "R-MMU-6804756", "R-CEL-3899300", "R-SPO-6804756", "R-DME-1538133", "R-MMU-8939243", "R-DME-6804756", "R-HSA-5578768", "R-MMU-1538133", "R-HSA-72163", "R-GGA-6804756", "R-HSA-8939243", "R-HSA-6804756", "R-CEL-1538133", "R-MMU-9022692", "R-DDI-6804756", "R-HSA-1538133", "R-RNO-6804756", "R-SCE-3899300", "R-HSA-3899300", "R-DDI-3899300", "R-SPO-3899300", "R-XTR-1538133", "R-RNO-1538133", "R-CEL-8939243"], "pathways": ["R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-72163:r:mRNA Splicing - Major Pathway", 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"R-DME-9634597:r:GPER1 signaling", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-RNO-5610787:r:Hedgehog 'off' state", "R-HSA-9010642:r:ROBO receptors bind AKAP5", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-9634597:r:GPER1 signaling", "R-DRE-5610787:r:Hedgehog 'off' state", "R-HSA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-9634597:r:GPER1 signaling", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-5610787:r:Hedgehog 'off' state", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DME-5610787:r:Hedgehog 'off' state", "R-DME-164378:r:PKA activation in glucagon signalling", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-9634597:r:GPER1 signaling", "R-SCE-5610787:r:Hedgehog 'off' state", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-164378:r:PKA activation in glucagon signalling", "R-CEL-163615:r:PKA activation", "R-DME-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-SPO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DDI-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SPO-9634597:r:GPER1 signaling", "R-SPO-5610787:r:Hedgehog 'off' state", "R-SPO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-180024:r:DARPP-32 events", "R-MMU-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DRE-163615:r:PKA activation", "R-GGA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-GGA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-RNO-163615:r:PKA activation", "R-BTA-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-CEL-180024:r:DARPP-32 events", "R-HSA-164378:r:PKA activation in glucagon signalling", "R-BTA-164378:r:PKA activation in glucagon signalling", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-180024:r:DARPP-32 events", "R-CEL-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-GGA-9634597:r:GPER1 signaling", "R-HSA-9634597:r:GPER1 signaling", "R-SPO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-SPO-163615:r:PKA activation", "R-GGA-164378:r:PKA activation in glucagon signalling", "R-GGA-163615:r:PKA activation", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-BTA-163615:r:PKA activation", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DDI-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-BTA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-180024:r:DARPP-32 events", "R-DME-163615:r:PKA activation", "R-GGA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-163615:r:PKA activation", "R-DDI-164378:r:PKA activation in glucagon signalling", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-163615:r:PKA activation", "R-CEL-164378:r:PKA activation in glucagon signalling", "R-DDI-9634597:r:GPER1 signaling", "R-SCE-9634597:r:GPER1 signaling", "R-SPO-164378:r:PKA activation in glucagon signalling", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-9660821:r:ADORA2B mediated anti-inflammatory cytokines production", "R-HSA-180024:r:DARPP-32 events", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-GGA-180024:r:DARPP-32 events", "R-RNO-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-DDI-5610787:r:Hedgehog 'off' state", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-DRE-164378:r:PKA activation in glucagon signalling", "R-GGA-5610787:r:Hedgehog 'off' state", "R-SCE-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-DME-180024:r:DARPP-32 events", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SPO-180024:r:DARPP-32 events", "R-MMU-164378:r:PKA activation in glucagon signalling", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-BTA-180024:r:DARPP-32 events", "R-DRE-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-RNO-432040:r:Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-5610787:r:Hedgehog 'off' state", "R-CEL-9634597:r:GPER1 signaling", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-BTA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-163615:r:PKA activation", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-BTA-442720:r:CREB1 phosphorylation through the activation of Adenylate Cyclase"], "type": "Family"}, "IPR050504": {"description": "BTN/MOG-like", "go_ids": [], "go_terms": [], "name": "IgSF_BTN/MOG-like", "pathway_ids": ["R-MMU-8851680", "R-RNO-8851680", "R-HSA-8851680", "R-MMU-9927354", "R-HSA-9927354"], "pathways": ["R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-9927354:r:Co-stimulation by ICOS", "R-HSA-9927354:r:Co-stimulation by ICOS"], "type": "Family"}, "IPR050505": {"description": "WD repeat-containing protein 55/POC1", "go_ids": [], "go_terms": [], "name": "WDR55/POC1", "pathway_ids": ["R-MMU-8951664", "R-HSA-983168", "R-RNO-983168", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR050507": {"description": "Platelet-derived/Vascular endothelial growth factor", "go_ids": [], "go_terms": [], "name": "PDGF/VEGF_growth_factor", "pathway_ids": ["R-DRE-114608", "R-HSA-1234158", "R-DRE-5218921", "R-MMU-4420097", "R-RNO-114608", "R-HSA-194313", "R-HSA-4420097", "R-HSA-114608", "R-BTA-114608", "R-BTA-4420097", "R-HSA-8866910", "R-BTA-195399", "R-HSA-195399", "R-MMU-5218921", "R-DRE-195399", "R-MMU-194313", "R-BTA-194313", "R-DRE-194313", "R-HSA-9679191", "R-HSA-6785807", "R-RNO-195399", "R-HSA-5218921", "R-MMU-195399", "R-MMU-114608", "R-RNO-5218921", "R-BTA-5218921", "R-DRE-4420097", "R-HSA-194138", "R-RNO-4420097", "R-RNO-194313"], "pathways": ["R-DRE-114608:r:Platelet degranulation", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-114608:r:Platelet degranulation", "R-HSA-194313:r:VEGF ligand-receptor interactions", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-BTA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-194313:r:VEGF ligand-receptor interactions", "R-BTA-194313:r:VEGF ligand-receptor interactions", "R-DRE-194313:r:VEGF ligand-receptor interactions", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-114608:r:Platelet degranulation", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-BTA-5218921:r:VEGFR2 mediated cell proliferation", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-194138:r:Signaling by VEGF", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-194313:r:VEGF ligand-receptor interactions"], "type": "Family"}, "IPR050508": {"description": "Methyltransferase Superfamily", "go_ids": [], "go_terms": [], "name": "Methyltransf_Superfamily", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR050509": {"description": "Coenzyme A-transferase family III", "go_ids": [], "go_terms": [], "name": "CoA-transferase_III", "pathway_ids": ["R-RNO-9033241", "R-MMU-389887", "R-RNO-193775", "R-HSA-193775", "R-MMU-193368", "R-RNO-389887", "R-MMU-193775", "R-RNO-193368", "R-HSA-389887", "R-HSA-193368", "R-MMU-9033241", "R-HSA-9033241"], "pathways": ["R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-HSA-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-193775:r:Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Family"}, "IPR050510": {"description": "Cation transport ATPase (P-type)", "go_ids": [], "go_terms": [], "name": "Cation_transp_ATPase_P-type", "pathway_ids": ["R-BTA-5578775", "R-RNO-5578775", "R-HSA-5578775", "R-MMU-5578775", "R-HSA-936837", "R-HSA-9679191", "R-MMU-936837", "R-SSC-5578775", "R-BTA-936837", "R-RNO-936837", "R-SSC-936837"], "pathways": ["R-BTA-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-5578775:r:Ion homeostasis", "R-HSA-936837:r:Ion transport by P-type ATPases", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-936837:r:Ion transport by P-type ATPases", "R-SSC-5578775:r:Ion homeostasis", "R-BTA-936837:r:Ion transport by P-type ATPases", "R-RNO-936837:r:Ion transport by P-type ATPases", "R-SSC-936837:r:Ion transport by P-type ATPases"], "type": "Family"}, "IPR050511": {"description": "AMP-activated protein kinase gamma/SDS23 families", "go_ids": [], "go_terms": [], "name": "AMPK_gamma/SDS23_families", "pathway_ids": ["R-HSA-9619483", "R-MMU-380972", "R-MMU-1632852", "R-SSC-5628897", "R-MMU-6804756", "R-DDI-200425", "R-HSA-5628897", "R-BTA-380972", "R-RNO-1632852", "R-BTA-6804756", "R-SPO-200425", "R-MMU-5628897", "R-SPO-163680", "R-RNO-6804756", "R-SSC-9931269", "R-HSA-9613354", "R-SCE-200425", "R-HSA-380972", "R-SCE-163680", "R-SSC-6804756", "R-DDI-163680", "R-MMU-163680", "R-HSA-9931269", "R-DDI-5628897", "R-SSC-380972", "R-DDI-1632852", "R-BTA-9931269", "R-SPO-5628897", "R-MMU-200425", "R-SPO-380972", "R-RNO-5628897", "R-RNO-9931269", "R-DDI-380972", "R-HSA-2151209", "R-BTA-1632852", "R-BTA-5628897", "R-SCE-1632852", "R-HSA-6804756", "R-SCE-380972", "R-SSC-1632852", "R-HSA-1445148", "R-MMU-9931269", "R-RNO-380972", "R-HSA-1632852", "R-HSA-200425", "R-SPO-1632852", "R-HSA-163680"], "pathways": ["R-HSA-9619483:r:Activation of AMPK downstream of NMDARs", "R-MMU-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-1632852:r:Macroautophagy", "R-SSC-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-200425:r:Carnitine shuttle", "R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-1632852:r:Macroautophagy", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-200425:r:Carnitine shuttle", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes", "R-SPO-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SSC-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9613354:r:Lipophagy", "R-SCE-200425:r:Carnitine shuttle", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SCE-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-SSC-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-MMU-163680:r:AMPK inhibits chREBP transcriptional activation activity", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-SSC-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DDI-1632852:r:Macroautophagy", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-SPO-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-200425:r:Carnitine shuttle", "R-SPO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-RNO-5628897:r:TP53 Regulates Metabolic Genes", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-2151209:r:Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "R-BTA-1632852:r:Macroautophagy", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-SCE-1632852:r:Macroautophagy", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-SSC-1632852:r:Macroautophagy", "R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-1632852:r:Macroautophagy", "R-HSA-200425:r:Carnitine shuttle", "R-SPO-1632852:r:Macroautophagy", "R-HSA-163680:r:AMPK inhibits chREBP transcriptional activation activity"], "type": "Family"}, "IPR050512": {"description": "Sulfate Adenylyltransferase/APS Kinase", "go_ids": [], "go_terms": [], "name": "Sulf_AdTrans/APS_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050513": {"description": "RavA family ATPases", "go_ids": [], "go_terms": [], "name": 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"R-SSC-6809371", "R-HSA-9830364", "R-HSA-6803157", "R-MMU-6798695", "R-HSA-9927418", "R-HSA-9927426"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-SSC-6803157:r:Antimicrobial peptides", "R-SSC-6809371:r:Formation of the cornified envelope", "R-HSA-9830364:r:Formation of the nephric duct", "R-HSA-6803157:r:Antimicrobial peptides", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9927426:r:Developmental Lineage of Mammary Gland Alveolar Cells"], "type": "Family"}, "IPR050515": {"description": "Class D beta-lactamase/transpeptidase", "go_ids": [], "go_terms": [], "name": "Beta-lactam/transpept", "pathway_ids": ["PWY-6471", "PWY-5265"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)"], "type": "Family"}, "IPR050516": {"description": "Olfactory G-protein coupled receptor", "go_ids": [], "go_terms": [], "name": "Olfactory_GPCR", "pathway_ids": ["R-HSA-381753", "R-HSA-9752946"], "pathways": ["R-HSA-381753:r:Olfactory Signaling Pathway", "R-HSA-9752946:r:Expression and translocation of olfactory receptors"], "type": "Family"}, "IPR050517": {"description": "DNA Damage Response and Repair Kinase", "go_ids": [], "go_terms": [], "name": "DDR_Repair_Kinase", "pathway_ids": ["R-HSA-5689880", "R-MMU-1632852", "R-DDI-6804760", "R-GGA-351433", "R-SPO-389357", "R-DDI-2559586", "R-MMU-6804756", "R-SPO-9639288", "R-HSA-9639288", "R-SPO-6804756", "R-RNO-5218920", "R-MMU-5685938", "R-MMU-69473", "R-HSA-5218920", "R-RNO-1632852", "R-SCE-6804757", "R-CEL-1257604", "R-DDI-5218920", "R-CEL-9639288", "R-DDI-6804756", "R-RNO-3371571", "R-CEL-165159", "R-RNO-165159", "R-HSA-3270619", "R-MMU-8866654", "R-HSA-5674400", "R-HSA-69473", "R-RNO-5628897", "R-HSA-6783310", "R-DME-5218920", "R-HSA-8866654", "R-RNO-6804757", "R-HSA-6804756", "R-DME-1257604", "R-HSA-389357", "R-DME-1632852", "R-DDI-5693548", "R-DME-165159", "R-DME-389357", "R-DDI-165159", "R-MMU-380972", "R-RNO-1257604", "R-CEL-3371571", "R-RNO-166208", "R-HSA-166208", "R-CEL-389357", "R-SPO-6803207", "R-SPO-6804757", "R-HSA-176187", "R-DDI-5689880", "R-MMU-5693607", "R-DME-176187", "R-DDI-5693616", "R-DDI-9639288", "R-DDI-5628897", "R-DDI-1632852", "R-MMU-975957", "R-MMU-6804757", "R-DDI-166208", "R-MMU-3371571", "R-CEL-380972", "R-MMU-1257604", "R-SPO-5693565", "R-CEL-6804757", "R-MMU-8943724", "R-MMU-6783310", "R-RNO-9856530", "R-HSA-201722", "R-HSA-5693571", "R-HSA-975957", "R-DDI-9664873", "R-HSA-3371571", "R-HSA-3214847", "R-HSA-9856530", "R-CEL-166208", "R-DME-9856530", "R-DME-5689880", "R-SCE-5218920", "R-CEL-9856530", "R-DME-9639288", "R-HSA-5693616", "R-DDI-5693571", "R-DDI-6803207", "R-DRE-201722", "R-SPO-3371571", "R-MMU-9639288", "R-SCE-389357", "R-HSA-6796648", "R-SPO-9664873", "R-DME-380972", "R-DDI-5693565", "R-DDI-6804757", "R-MMU-389357", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-DME-3371571", "R-HSA-6804757", "R-HSA-8943724", "R-SCE-9664873", "R-MMU-5628897", "R-SCE-9856530", "R-RNO-389357", "R-MMU-165159", "R-CEL-5628897", "R-DME-69473", "R-SPO-5218920", "R-DDI-380972", "R-DDI-9856530", "R-RNO-380972", "R-HSA-1632852", "R-MMU-176187", "R-RNO-9639288", "R-HSA-1257604", "R-MMU-5693571", "R-DME-5628897", "R-DME-8943724", "R-RNO-8943724", "R-MMU-9856530", "R-SCE-9639288", "R-CEL-1632852", "R-SCE-2559586", "R-CEL-201722", "R-HSA-1221632", "R-HSA-5628897", "R-SCE-5693565", "R-CEL-8943724", "R-DME-166208", "R-SCE-1257604", "R-HSA-1834949", "R-SCE-5693548", "R-HSA-9920951", "R-DDI-5693607", "R-SPO-1257604", "R-SCE-3371571", "R-HSA-380972", "R-HSA-5685938", "R-SPO-9856530", "R-DRE-5689880", "R-GGA-353423", "R-DDI-1257604", "R-MMU-5218920", "R-DRE-975957", "R-DDI-3371571", "R-DME-201722", "R-DDI-8943724", "R-DDI-349425", "R-SPO-2559586", "R-HSA-165159", "R-DDI-389357", "R-MMU-166208", "R-SPO-5693548", "R-CEL-5218920"], "pathways": 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activates/modulates innate immune responses", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9682708:r:Transcription of SARS-CoV-1 sgRNAs", "R-HSA-9694301:r:Maturation of replicase proteins", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Family"}, "IPR050535": {"description": "DNA Repair and Maintenance Complex Component", "go_ids": [], "go_terms": [], "name": "DNA_Repair-Maintenance_Comp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050537": {"description": "2-oxoacid dehydrogenase", "go_ids": [], "go_terms": [], "name": "2-oxoacid_dehydrogenase", "pathway_ids": ["PWY-5084", "R-MMU-6783984", "R-SCE-9853506", "R-MMU-9857492", "R-SPO-9853506", "R-HSA-9853506", "R-SCE-6783984", "R-RNO-9857492", "R-SCE-9857492", "R-DDI-9857492", "R-RNO-9853506", "R-RNO-9858328", "R-HSA-9857492", "R-DDI-9858328", "R-SPO-9857492", "R-RNO-6783984", "R-DDI-9853506", "R-HSA-9858328", "R-HSA-6783984", "R-DDI-6783984", "R-SPO-6783984", "R-MMU-9858328", "R-MMU-9853506"], "pathways": ["PWY-5084:t:2-oxoglutarate decarboxylation to succinyl-CoA", "R-MMU-6783984:r:Glycine degradation", "R-SCE-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-MMU-9857492:r:Protein lipoylation", "R-SPO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-SCE-6783984:r:Glycine degradation", "R-RNO-9857492:r:Protein lipoylation", "R-SCE-9857492:r:Protein lipoylation", "R-DDI-9857492:r:Protein lipoylation", "R-RNO-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-RNO-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-9857492:r:Protein lipoylation", "R-DDI-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-SPO-9857492:r:Protein lipoylation", "R-RNO-6783984:r:Glycine degradation", "R-DDI-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG", "R-HSA-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-HSA-6783984:r:Glycine degradation", "R-DDI-6783984:r:Glycine degradation", "R-SPO-6783984:r:Glycine degradation", "R-MMU-9858328:r:OADH complex synthesizes glutaryl-CoA from 2-OA", "R-MMU-9853506:r:OGDH complex synthesizes succinyl-CoA from 2-OG"], "type": "Family"}, "IPR050538": {"description": "Mitogen-activated protein kinase kinase kinase", "go_ids": [], "go_terms": [], "name": "MAP_kinase_kinase_kinase", "pathway_ids": ["R-MMU-5684264", "R-HSA-975871", "R-HSA-166058", "R-HSA-5607761", "R-HSA-975138", "R-MMU-5676594", "R-HSA-2871796", "R-HSA-933542", "R-RNO-5684264", "R-HSA-5676594", "R-HSA-5676590", "R-MMU-5607761", "R-MMU-5676590", "R-MMU-389357", "R-HSA-5668541", "R-HSA-5684264", "R-MMU-5668541", "R-HSA-389357", "R-SPO-2871796", "R-RNO-389357"], "pathways": 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"R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-2871796:r:FCERI mediated MAPK activation", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling"], "type": "Family"}, "IPR050539": {"description": "ThrE Dicarboxylate/Amino Acid Exporter", "go_ids": [], "go_terms": [], "name": "ThrE_Dicarb/AminoAcid_Exp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050540": {"description": "F-actin Monooxygenase Mical", "go_ids": [], "go_terms": [], "name": "F-actin_Monoox_Mical", "pathway_ids": ["R-HSA-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Family"}, "IPR050541": {"description": "Leucine-rich repeat and transmembrane domain-containing protein", "go_ids": [], "go_terms": [], "name": "LRR_TM_domain-containing", "pathway_ids": ["R-HSA-388844", "R-MMU-163125", "R-RNO-430116", "R-HSA-193634", 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tyrosine-protein phosphatases", "R-HSA-6794361:r:Neurexins and neuroligins", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation"], "type": "Family"}, "IPR050543": {"description": "Eukaryotic Initiation Factor 2 Gamma Subunit", "go_ids": [], "go_terms": [], "name": "eIF2G", "pathway_ids": ["R-HSA-72731", "R-DRE-382556", "R-SCE-382556", "R-SPO-72702", "R-SPO-382556", "R-DME-156827", "R-DDI-382556", "R-BTA-382556", "R-HSA-9833482", "R-DME-382556", "R-HSA-381042", "R-SPO-72731", "R-RNO-9840373", "R-RNO-382556", "R-DME-72649", "R-HSA-156827", "R-DME-381042", "R-RNO-72695", "R-DRE-72731", "R-HSA-72695", "R-MMU-381042", "R-MMU-72649", "R-DRE-381042", "R-SCE-72731", "R-MMU-72702", "R-MMU-72731", "R-MMU-72706", "R-BTA-72695", "R-BTA-381042", "R-BTA-72731", "R-DRE-9840373", "R-SCE-72695", "R-SCE-72702", "R-BTA-9840373", "R-MMU-72695", "R-HSA-9840373", "R-DRE-156827", "R-SCE-156827", "R-DME-72695", "R-BTA-156827", "R-MMU-382556", "R-RNO-156827", "R-DRE-72695", "R-SPO-72706", 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{"description": "DEAD box ATP-dependent RNA helicases", "go_ids": [], "go_terms": [], "name": "DEAD_box_RNA_helicases", "pathway_ids": ["R-RNO-5250924", "R-RNO-6791226"], "pathways": ["R-RNO-5250924:r:B-WICH complex positively regulates rRNA expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR050548": {"description": "Polycomb group and chromatin remodeling factors", "go_ids": [], "go_terms": [], "name": "PcG_chromatin_remod_factors", "pathway_ids": ["R-HSA-4655427", "R-MMU-8953750", "R-DME-8939243", "R-HSA-3108214", "R-HSA-2559580", "R-DRE-2559580", "R-MMU-4570464", "R-RNO-8953750", "R-DRE-8953750", "R-DRE-8939243", "R-HSA-8953750", "R-DRE-4570464", "R-DME-2559580", "R-DRE-3108214", "R-MMU-4551638", "R-DME-4570464", "R-HSA-8943724", "R-DME-3899300", "R-HSA-4570464", "R-DME-8953750", "R-HSA-4551638", "R-DME-3108214", "R-MMU-6804760", "R-MMU-3899300", "R-DME-4551638", "R-HSA-6804760", "R-RNO-6804760", "R-MMU-8939243", "R-MMU-8943724", "R-DRE-3899300", "R-RNO-4551638", "R-HSA-8939243", "R-MMU-3108214", "R-HSA-3899300", "R-DME-8943724"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-4570464:r:SUMOylation of RNA binding proteins", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-3108214:r:SUMOylation of DNA 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transcription", "R-DRE-3899300:r:SUMOylation of transcription cofactors", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-DME-8943724:r:Regulation of PTEN gene transcription"], "type": "Family"}, "IPR050549": {"description": "Major Facilitator Superfamily Trehalose Transporter", "go_ids": [], "go_terms": [], "name": "MFS_Trehalose_Transporter", "pathway_ids": ["R-MMU-189200", "R-MMU-8856828", "R-RNO-189200", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-DME-189200", "R-HSA-8856828", "R-RNO-8856828", "R-HSA-189200"], "pathways": ["R-MMU-189200:r:Cellular hexose transport", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-189200:r:Cellular hexose transport", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-189200:r:Cellular hexose transport", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-189200:r:Cellular hexose transport"], "type": "Family"}, "IPR050550": {"description": "SEC23/SEC24 family, SEC24 subfamily", "go_ids": [], "go_terms": [], "name": "SEC23_SEC24_subfamily", "pathway_ids": ["R-HSA-1655829", "R-MMU-204005", "R-DDI-983170", "R-HSA-2132295", "R-DDI-204005", "R-HSA-9705671", "R-DDI-5694530", "R-MMU-5694530", "R-SCE-204005", "R-SPO-204005", "R-SPO-5694530", "R-HSA-5694530", "R-BTA-983170", "R-HSA-204005", "R-HSA-983170", "R-SCE-5694530", "R-BTA-5694530", "R-MMU-2132295", "R-MMU-983170", "R-BTA-204005", "R-BTA-2132295", "R-SPO-983170", "R-SCE-983170"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DDI-5694530:r:Cargo concentration in the ER", "R-MMU-5694530:r:Cargo concentration in the ER", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SPO-5694530:r:Cargo concentration in the ER", "R-HSA-5694530:r:Cargo concentration in the ER", "R-BTA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-5694530:r:Cargo concentration in the ER", "R-BTA-5694530:r:Cargo concentration in the ER", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-BTA-204005:r:COPII-mediated vesicle transport", "R-BTA-2132295:r:MHC class II antigen presentation", "R-SPO-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "R-SCE-983170:r:Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "type": "Family"}, "IPR050551": {"description": "Plant Fructan Metabolism Enzymes", "go_ids": [], "go_terms": [], "name": "Fructan_Metab_Enzymes", "pathway_ids": ["PWY-8314"], "pathways": ["PWY-8314:t:inulin degradation"], "type": "Family"}, "IPR050552": {"description": "LacD aldolase", "go_ids": [], "go_terms": [], "name": "LacD_aldolase", "pathway_ids": ["PWY-8324", "PWY-7395", "PWY-7077"], "pathways": ["PWY-8324:t:D-tagatose degradation", "PWY-7395:t:D-galactosamine and N-acetyl-D-galactosamine degradation", "PWY-7077:t:N-acetyl-D-galactosamine degradation"], "type": "Family"}, "IPR050553": {"description": "Thioredoxin family ResA/DsbE subfamily", "go_ids": [], "go_terms": [], "name": "Thioredoxin_ResA/DsbE_sf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050554": {"description": "Methionine Synthase/Corrinoid", "go_ids": [], "go_terms": [], "name": "Met_Synthase/Corrinoid", "pathway_ids": ["R-CEL-156581", "R-RNO-1614635", "R-MMU-9013407", "R-CEL-9759218", "R-RNO-9759218", "R-RNO-9013407", "R-HSA-1614635", "R-DDI-9759218", "R-MMU-156581", "R-HSA-3359469", "R-CEL-1614635", "R-CEL-9013407", "R-DDI-1614635", "R-MMU-9759218", "R-MMU-1614635", "R-HSA-156581", "R-HSA-9759218", "R-RNO-156581", "R-HSA-3359467", "R-DDI-156581", "R-HSA-9013407"], "pathways": ["R-CEL-156581:r:Methylation", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-CEL-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-1614635:r:Sulfur amino acid metabolism", "R-DDI-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-156581:r:Methylation", "R-HSA-3359469:r:Defective MTR causes HMAG", "R-CEL-1614635:r:Sulfur amino acid metabolism", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DDI-1614635:r:Sulfur amino acid metabolism", "R-MMU-9759218:r:Cobalamin (Cbl) metabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-156581:r:Methylation", "R-HSA-9759218:r:Cobalamin (Cbl) metabolism", "R-RNO-156581:r:Methylation", "R-HSA-3359467:r:Defective MTRR causes HMAE", "R-DDI-156581:r:Methylation", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR050555": {"description": "Bacterial Solute-Binding Protein 2", "go_ids": [], "go_terms": [], "name": "Bact_Solute-Bind_Prot2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050556": {"description": "Type II toxin-antitoxin system RNase", "go_ids": [], "go_terms": [], "name": "Type_II_TA_system_RNase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050557": {"description": "RTX toxin 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1-2/Carboxylesterase-like", "go_ids": [], "go_terms": [], "name": "LYPA1-2/EST-like", "pathway_ids": ["R-DDI-203615", "R-MMU-373760", "R-MMU-9648002", "R-SPO-9648002", "R-SCE-9648002", "R-SCE-203615", "R-RNO-373760", "R-MMU-203615", "R-RNO-9648002", "R-HSA-9648002", "R-DDI-9648002", "R-HSA-373760", "R-HSA-203615", "R-RNO-203615", "R-SPO-203615"], "pathways": ["R-DDI-203615:r:eNOS activation", "R-MMU-373760:r:L1CAM interactions", "R-MMU-9648002:r:RAS processing", "R-SPO-9648002:r:RAS processing", "R-SCE-9648002:r:RAS processing", "R-SCE-203615:r:eNOS activation", "R-RNO-373760:r:L1CAM interactions", "R-MMU-203615:r:eNOS activation", "R-RNO-9648002:r:RAS processing", "R-HSA-9648002:r:RAS processing", "R-DDI-9648002:r:RAS processing", "R-HSA-373760:r:L1CAM interactions", "R-HSA-203615:r:eNOS activation", "R-RNO-203615:r:eNOS activation", "R-SPO-203615:r:eNOS activation"], "type": "Family"}, "IPR050566": {"description": "Deoxyribonucleoside Kinase", "go_ids": [], "go_terms": [], "name": "Deoxyribonucleoside_kinase", "pathway_ids": ["R-BTA-74217", "R-HSA-73614", "R-MMU-6799198", "R-HSA-6799198", "R-DME-6799198", "R-RNO-74217", "R-RNO-6799198", "R-MMU-73614", "R-DME-73614", "R-DME-611105", "R-RNO-611105", "R-HSA-611105", "R-DDI-74217", "R-RNO-73614", "R-MMU-74217", "R-MMU-611105", "R-HSA-74217", "R-BTA-73614", "R-DDI-73614"], "pathways": ["R-BTA-74217:r:Purine salvage", "R-HSA-73614:r:Pyrimidine salvage", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-RNO-74217:r:Purine salvage", "R-RNO-6799198:r:Complex I biogenesis", "R-MMU-73614:r:Pyrimidine salvage", "R-DME-73614:r:Pyrimidine salvage", "R-DME-611105:r:Respiratory electron transport", "R-RNO-611105:r:Respiratory electron transport", "R-HSA-611105:r:Respiratory electron transport", "R-DDI-74217:r:Purine salvage", "R-RNO-73614:r:Pyrimidine salvage", "R-MMU-74217:r:Purine salvage", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-74217:r:Purine salvage", "R-BTA-73614:r:Pyrimidine salvage", "R-DDI-73614:r:Pyrimidine salvage"], "type": "Family"}, "IPR050567": {"description": "Mitochondrial Carrier", "go_ids": [], "go_terms": [], "name": "Mitochondrial_Carrier", "pathway_ids": ["R-SPO-352230", "R-SPO-70635", "R-DME-200425", "R-MMU-200425", "R-HSA-70635", "R-DDI-70635", "R-HSA-9956508", "R-BTA-352230", "R-CEL-200425", "R-MMU-352230", "R-RNO-70635", "R-MMU-70635", "R-HSA-352230", "R-RNO-352230", "R-HSA-200425", "R-RNO-200425", "R-SCE-70635", "R-SCE-200425"], "pathways": ["R-SPO-352230:r:Amino acid transport across the plasma membrane", "R-SPO-70635:r:Urea cycle", "R-DME-200425:r:Carnitine shuttle", "R-MMU-200425:r:Carnitine shuttle", "R-HSA-70635:r:Urea cycle", "R-DDI-70635:r:Urea cycle", "R-HSA-9956508:r:SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome", "R-BTA-352230:r:Amino acid transport across the plasma membrane", "R-CEL-200425:r:Carnitine shuttle", "R-MMU-352230:r:Amino acid transport across the plasma membrane", "R-RNO-70635:r:Urea cycle", "R-MMU-70635:r:Urea cycle", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-HSA-200425:r:Carnitine shuttle", "R-RNO-200425:r:Carnitine shuttle", "R-SCE-70635:r:Urea cycle", "R-SCE-200425:r:Carnitine shuttle"], "type": "Family"}, "IPR050568": {"description": "Transcription/DNA replication regulator", "go_ids": [], "go_terms": [], "name": "Transcr_DNA_Rep_Reg", "pathway_ids": ["R-HSA-1989781", "R-DME-110314", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656169", "R-HSA-5696397", "R-BTA-68962", "R-MMU-110314", "R-DME-68962", "R-HSA-380994", "R-HSA-1181150", "R-BTA-5651801", "R-BTA-5696397", "R-HSA-68962", "R-HSA-6782210", "R-BTA-5656169", "R-BTA-110314", "R-DME-68952", "R-BTA-5696400", "R-HSA-5656169", "R-HSA-9614657", "R-DME-6782135", "R-SCE-68952", "R-MMU-5696400", "R-SPO-5696397", "R-HSA-381183", "R-DME-5651801", "R-HSA-68952", "R-MMU-68962", "R-BTA-6782135", "R-MMU-5651801", "R-MMU-5656169", "R-HSA-6782135", "R-HSA-1502540", "R-MMU-5685942", "R-HSA-5651801", "R-SCE-68962", "R-MMU-68952", "R-DME-5656169", "R-SPO-5696400", "R-SPO-68952", "R-DME-5696400", "R-SPO-6782210", "R-SPO-110314", "R-BTA-5685942", "R-SPO-68962", "R-BTA-6782210", "R-HSA-5696400", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-HSA-110314", "R-BTA-68952", "R-HSA-2426168", "R-SCE-6782135", "R-SPO-5651801"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-MMU-110314:r:Recognition of DNA damage by 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"R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-381183:r:ATF6 (ATF6-alpha) activates chaperone genes", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-68952:r:DNA replication initiation", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-BTA-6782135:r:Dual incision in TC-NER", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-1502540:r:Signaling by Activin", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-MMU-68952:r:DNA replication initiation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-68952:r:DNA replication initiation", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-BTA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-BTA-68952:r:DNA replication initiation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Family"}, "IPR050569": {"description": "Trace Amine-Associated Receptor", "go_ids": [], 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"PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "R-RNO-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-611105:r:Respiratory electron transport", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-SPO-71403:r:Citric acid cycle (TCA cycle)", "R-HSA-71403:r:Citric acid cycle (TCA cycle)", "R-CEL-71403:r:Citric acid cycle (TCA cycle)", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-MMU-71403:r:Citric acid cycle (TCA cycle)", "R-SCE-71403:r:Citric acid cycle (TCA cycle)", "R-XTR-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DME-71403:r:Citric acid cycle (TCA cycle)", "R-DDI-71403:r:Citric acid cycle (TCA cycle)", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-RNO-71403:r:Citric acid cycle (TCA cycle)", "R-GGA-372987:r:The tricarboxylic acid cycle", "R-XTR-71403:r:Citric acid 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"type": "Family"}, "IPR050577": {"description": "MAPR/Neuferricin/Neudesin-like", "go_ids": [], "go_terms": [], "name": "MAPR/NEUFC/NENF-like", "pathway_ids": ["R-HSA-6798695", "R-HSA-9013405", "R-SPO-6798695", "R-SSC-6798695", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-HSA-9707616", "R-MMU-9013404", "R-GGA-6798695", "R-RNO-9013423", "R-HSA-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-SPO-9707616", "R-HSA-8980692", "R-MMU-9707616", "R-MMU-6798695", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-9013408", "R-RNO-9707616", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013405:r:RHOD GTPase cycle", "R-SPO-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9707616:r:Heme signaling", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-GGA-6798695:r:Neutrophil degranulation", "R-RNO-9013423:r:RAC3 GTPase cycle", 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["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "type": "Family"}, "IPR050580": {"description": "2H phosphoesterase superfamily YjcG-like protein", "go_ids": [], "go_terms": [], "name": "2H_phosphoesterase_YjcG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050581": {"description": "Cysteine-rich repeat secretory protein", "go_ids": [], "go_terms": [], "name": "CRR_secretory_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050582": {"description": "HAD-like hydrolase superfamily, SerB", "go_ids": [], "go_terms": [], "name": "HAD-like_SerB", "pathway_ids": ["R-MMU-977347", "R-RNO-977347", "R-HSA-977347", "R-DME-977347", "R-SPO-977347", "R-BTA-977347", "R-SCE-977347"], "pathways": ["R-MMU-977347:r:Serine metabolism", "R-RNO-977347:r:Serine metabolism", "R-HSA-977347:r:Serine metabolism", "R-DME-977347:r:Serine metabolism", "R-SPO-977347:r:Serine metabolism", "R-BTA-977347:r:Serine metabolism", "R-SCE-977347:r:Serine 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"R-HSA-3858516", "R-SCE-70221", "R-HSA-3322077", "R-SPO-70221", "R-HSA-3878781", "R-HSA-3814836", "R-HSA-3828062", "R-MMU-6798695", "R-RNO-3322077", "R-RNO-6798695"], "pathways": ["R-MMU-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-CEL-3322077:r:Glycogen synthesis", "R-HSA-70221:r:Glycogen breakdown (glycogenolysis)", "R-MMU-3322077:r:Glycogen synthesis", "R-HSA-5357609:r:Glycogen storage disease type II (GAA)", "R-CEL-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-3322077:r:Glycogen synthesis", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-CEL-70221:r:Glycogen breakdown (glycogenolysis)", "R-RNO-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-3858516:r:Glycogen storage disease type 0 (liver GYS2)", "R-SCE-70221:r:Glycogen breakdown (glycogenolysis)", "R-HSA-3322077:r:Glycogen synthesis", "R-SPO-70221:r:Glycogen breakdown (glycogenolysis)", 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"R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-RNO-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-SPO-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Family"}, "IPR050592": {"description": "GDSL lipolytic enzyme", "go_ids": [], "go_terms": [], "name": "GDSL_lipolytic_enzyme", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Family"}, "IPR050593": {"description": "Lovastatin nonaketide synthase thioesterase", "go_ids": [], "go_terms": [], "name": "LovG", "pathway_ids": ["PWY-6997", "PWY-7007", "PWY-7401", "PWY-6322", "PWY-7769", "PWY-6585", "PWY-8210", "PWY-7734", "PWY-8184", "PWY-8337", "PWY-7740", "PWY-6948", "PWY-981", "PWY-8058", "PWY-7733", "PWY-7706", "PWY-7402", "PWY-8012", "PWY-7931", "PWY-5109", "PWY-6995", "PWY-8042", "PWY-3602", "PWY-7738", "PWY-7690", "PWY-7216", "PWY-7930", "PWY-7292", "PWY-8339", "PWY-7742", "PWY-7471", "PWY-6917", "PWY-7741"], "pathways": ["PWY-6997:t:furfural degradation", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-6585:t:2-methylketone biosynthesis", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-8184:t:L-isoleucine degradation III (oxidative Stickland reaction)", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-981:t:salicylate biosynthesis III", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7402:t:benzoate fermentation (to acetate and cyclohexane 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{"description": "Aspartate/prephenate aminotransferase-like", "go_ids": ["GO:0008483", "GO:0006520"], "go_terms": ["GO:0008483:transaminase activity:F", "GO:0006520:amino acid metabolic process:P"], "name": "AspAT/PAT-like", "pathway_ids": ["PWY-7383", "PWY-6638", "PWY-7115", "PWY-6643", "PWY-7117", "PWY-6642"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-6638:t:sulfolactate degradation III", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-6643:t:coenzyme M biosynthesis II", "PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-6642:t:(R)-cysteate degradation"], "type": "Family"}, "IPR050597": {"description": "Cytochrome c Oxidase Subunit", "go_ids": [], "go_terms": [], "name": "Cytochrome_c_Oxidase_Subunit", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050598": {"description": "Cellular Amino Acid Transporter", "go_ids": [], "go_terms": [], "name": "AminoAcid_Transporter", 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and strand exchange", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DME-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5693548:r:Sensing of DNA Double Strand Breaks", "R-SCE-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-RNO-5685938:r:HDR through Single Strand Annealing (SSA)", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-CEL-3214847:r:HATs acetylate histones", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-MMU-3214847:r:HATs acetylate histones", "R-RNO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-5693548:r:Sensing of DNA Double Strand Breaks", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones", "R-SPO-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9733709:r:Cardiogenesis", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange"], "type": "Family"}, "IPR050604": {"description": "PDZ and LIM domain-containing", "go_ids": [], "go_terms": [], "name": "PDZ-LIM_domain", "pathway_ids": ["R-MMU-8853659", "R-DRE-8853659", "R-DDI-8849471", "R-DDI-446388", "R-HSA-8853659", "R-BTA-8853659", "R-RNO-8853659", "R-HSA-6794361"], "pathways": ["R-MMU-8853659:r:RET signaling", "R-DRE-8853659:r:RET signaling", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DDI-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-8853659:r:RET signaling", "R-BTA-8853659:r:RET signaling", "R-RNO-8853659:r:RET signaling", "R-HSA-6794361:r:Neurexins and neuroligins"], "type": "Family"}, "IPR050605": {"description": "Olfactomedin-like domain-containing protein", "go_ids": [], "go_terms": [], "name": "Olfactomedin-like_domain", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR050606": {"description": "Calponin-like", "go_ids": [], "go_terms": [], "name": "Calponin-like", "pathway_ids": ["R-HSA-6798695", "R-HSA-114608", "R-BTA-114608", "R-DME-6798695", "R-DME-114608", "R-HSA-9927432", "R-SCE-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-SCE-114608", "R-HSA-8950505", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-114608:r:Platelet degranulation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-SCE-114608:r:Platelet degranulation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR050607": {"description": "Nitric Oxide Synthase (NOS)", "go_ids": [], "go_terms": [], "name": "NOS", "pathway_ids": ["PWY-4983", "R-MMU-1222556", "R-SSC-9033241", "R-MMU-9856530", "R-HSA-1474151", "R-HSA-392154", "R-DME-1222556", "R-RNO-9009391", "R-MMU-203615", "R-MMU-9009391", "R-MMU-203641", "R-RNO-1222556", "R-RNO-392154", "R-RNO-5218920", "R-HSA-203615", "R-RNO-9033241", "R-HSA-5218920", "R-HSA-1222556", "R-RNO-1474151", "R-MMU-392154", "R-DME-9009391", "R-HSA-5578775", "R-RNO-203641", "R-HSA-203641", "R-RNO-203754", "R-SSC-1222556", "R-HSA-9636249", "R-MMU-5218920", "R-DME-392154", "R-DME-5578775", "R-RNO-5578775", "R-DME-9033241", "R-MMU-5578775", "R-MMU-9033241", "R-HSA-6785807", "R-SSC-392154", "R-DME-203615", "R-MMU-1474151", "R-RNO-203615", "R-DME-5218920", "R-RNO-9856530", "R-HSA-203754", "R-HSA-9009391", "R-MMU-203754", "R-DME-203754", "R-DME-1474151", "R-HSA-9856530", "R-HSA-9033241", "R-DME-9856530"], "pathways": ["PWY-4983:t:nitric oxide biosynthesis II (mammals)", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-SSC-9033241:r:Peroxisomal protein import", "R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203615:r:eNOS activation", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-392154:r:Nitric oxide stimulates guanylate cyclase", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-203615:r:eNOS activation", "R-RNO-9033241:r:Peroxisomal protein import", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-RNO-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-MMU-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-203641:r:NOSTRIN mediated eNOS trafficking", "R-HSA-203641:r:NOSTRIN mediated eNOS trafficking", "R-RNO-203754:r:NOSIP mediated eNOS trafficking", "R-SSC-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-5578775:r:Ion homeostasis", "R-RNO-5578775:r:Ion homeostasis", "R-DME-9033241:r:Peroxisomal protein import", "R-MMU-5578775:r:Ion homeostasis", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-392154:r:Nitric oxide stimulates guanylate cyclase", "R-DME-203615:r:eNOS activation", "R-MMU-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-RNO-203615:r:eNOS activation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-203754:r:NOSIP mediated eNOS trafficking", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-203754:r:NOSIP mediated eNOS trafficking", "R-DME-203754:r:NOSIP mediated eNOS trafficking", "R-DME-1474151:r:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Family"}, "IPR050608": {"description": "NmrA-type oxidoreductase, Isoflavone reductase subfamily", "go_ids": [], "go_terms": [], "name": "NmrA-type/Isoflavone_red_sf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050609": {"description": "Antp homeobox family, 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"R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-75094:r:Formation of the Editosome"], "type": "Family"}, "IPR050611": {"description": "ABCF protein", "go_ids": [], "go_terms": [], "name": "ABCF", "pathway_ids": ["R-MMU-382556", "R-SCE-382556", "R-SPO-382556", "R-RNO-382556", "R-DDI-382556", "R-HSA-9818032", "R-HSA-382556"], "pathways": ["R-MMU-382556:r:ABC-family proteins mediated transport", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-HSA-382556:r:ABC-family proteins mediated transport"], "type": "Family"}, "IPR050612": {"description": "Prokaryotic Molybdopterin Oxidoreductases", "go_ids": [], "go_terms": [], "name": "Prok_Mopterin_Oxidored", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050614": {"description": "Synaptic Scaffolding LAP/MAGUK Families", "go_ids": [], "go_terms": [], "name": "Synaptic_Scaffolding_LAP-MAGUK", "pathway_ids": ["R-DME-5625900", "R-CEL-8849932", "R-MMU-8863795", "R-HSA-5625900", "R-MMU-8980692", "R-DRE-438066", "R-HSA-9665737", "R-HSA-9665348", "R-HSA-9013106", "R-HSA-8849932", "R-HSA-6794361", "R-HSA-9665245", "R-HSA-9013423", "R-CEL-5625900", "R-DRE-9696264", "R-HSA-9013148", "R-DME-9013406", "R-RNO-451308", "R-HSA-9617324", "R-HSA-399719", "R-XTR-8849932", "R-HSA-9665249", "R-CEL-6794361", "R-HSA-9696270", "R-HSA-9665246", "R-DME-6798695", "R-HSA-5666185", "R-MMU-1227986", "R-MMU-6794361", "R-HSA-1227986", "R-HSA-9665233", "R-RNO-399719", "R-HSA-9665250", "R-DME-451308", "R-HSA-1236394", "R-RNO-5625900", "R-DME-8849932", "R-DRE-9013148", "R-HSA-438066", "R-HSA-9634285", "R-MMU-9013026", "R-XTR-438066", "R-DME-6794361", "R-CFA-438066", "R-HSA-5682910", "R-HSA-9013406", "R-MMU-9696270", "R-MMU-399719", "R-HSA-9013409", "R-HSA-6798695", "R-MMU-451308", "R-MMU-9013106", "R-HSA-9665251", "R-MMU-9013408", "R-CEL-438066", "R-MMU-9013404", "R-HSA-442982", "R-DRE-9013406", "R-CFA-451308", "R-CFA-8849932", "R-HSA-8863795", "R-CEL-451308", "R-MMU-9652282", "R-CFA-5673001", "R-HSA-9013408", "R-HSA-9665247", "R-HSA-9664565", "R-HSA-447038", "R-RNO-5673001", "R-MMU-5673001", "R-DME-438066", "R-DRE-9696270", "R-HSA-9652282", "R-RNO-5682910", "R-HSA-451308", "R-HSA-9665244", "R-HSA-9665686", "R-MMU-8849932", "R-MMU-438066", "R-MMU-5625900", "R-RNO-438066", "R-HSA-5673001", "R-HSA-9696264", "R-DRE-8849932", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-4608870", "R-HSA-9620244", "R-MMU-9013406", "R-MMU-9013149", "R-CFA-399719", "R-MMU-5682910", "R-HSA-9013026", "R-MMU-6798695", "R-MMU-9696264", "R-RNO-6794361", "R-RNO-8849932", "R-HSA-9609736", "R-RNO-6798695"], "pathways": ["R-DME-5625900:r:RHO GTPases activate CIT", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-MMU-8863795:r:Downregulation of 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"R-RNO-8984722", "R-BTA-8984722", "R-HSA-6785807", "R-HSA-6783783", "R-BTA-9020591", "R-HSA-8984722", "R-HSA-9020933"], "pathways": ["R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-9020591:r:Interleukin-12 signaling", "R-SSC-9020591:r:Interleukin-12 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-RNO-9020591:r:Interleukin-12 signaling", "R-MMU-9020933:r:Interleukin-23 signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-BTA-8984722:r:Interleukin-35 Signalling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-BTA-9020591:r:Interleukin-12 signaling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-HSA-9020933:r:Interleukin-23 signaling"], "type": "Family"}, "IPR050677": {"description": "Actinoporin Pore-Forming Toxin", "go_ids": [], "go_terms": [], "name": "Actinoporin_PFT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050678": {"description": "DNA 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"Family"}, "IPR050689": {"description": "FKBP-type Peptidyl-prolyl cis-trans Isomerase", "go_ids": [], "go_terms": [], "name": "FKBP-type_PPIase", "pathway_ids": ["R-DME-2173789", "R-MMU-2173789", "R-BTA-166208", "R-HSA-3656535", "R-HSA-2173791", "R-RNO-5578775", "R-HSA-2672351", "R-DME-2025928", "R-DDI-166208", "R-MMU-5578775", "R-HSA-9679191", "R-SPO-166208", "R-BTA-2173789", "R-SCE-2025928", "R-RNO-166208", "R-BTA-2672351", "R-HSA-2025928", "R-RNO-2672351", "R-HSA-166208", "R-MMU-2672351", "R-RNO-2025928", "R-DME-166208", "R-HSA-9692916", "R-BTA-5578775", "R-MMU-166208", "R-MMU-2025928", "R-HSA-5578775", "R-SPO-2025928", "R-SCE-166208", "R-BTA-2025928", "R-RNO-2173789", "R-HSA-2173789", "R-DDI-2025928"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-BTA-166208:r:mTORC1-mediated signalling", "R-HSA-3656535:r:TGFBR1 LBD Mutants in Cancer", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT 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"R-RNO-3000178:r:ECM proteoglycans", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-BTA-2024101:r:CS/DS degradation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-SSC-3000178:r:ECM proteoglycans", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2024101:r:CS/DS degradation", "R-BTA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-SSC-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-SSC-2022857:r:Keratan sulfate degradation", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022857:r:Keratan sulfate degradation", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-HSA-419037:r:NCAM1 interactions", "R-RNO-2022857:r:Keratan sulfate degradation", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-2022857:r:Keratan sulfate degradation", "R-HSA-3656244:r:Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-3656225:r:Defective CHST6 causes MCDC1", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-MMU-2024101:r:CS/DS degradation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-2022923:r:DS-GAG biosynthesis", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type"], "type": "Family"}, "IPR050692": {"description": "HTH-type transcriptional 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"go_ids": [], "go_terms": [], "name": "FtsA/MreB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050697": {"description": "Adenylyl/Guanylyl Cyclase Class-3/4", "go_ids": [], "go_terms": [], "name": "Adenylyl/Guanylyl_Cyclase_3/4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050698": {"description": "RNA Processing Metallo-Beta-Lactamase", "go_ids": [], "go_terms": [], "name": "MBL", "pathway_ids": ["R-RNO-6807505", "R-HSA-6807505", "R-HSA-9770562", "R-DME-77595", "R-MMU-9770562", "R-SPO-159231", "R-SCE-77595", "R-MMU-77595", "R-BTA-73856", "R-MMU-73856", "R-HSA-73856", "R-DDI-9770562", "R-DME-159231", "R-HSA-72187", "R-SPO-77595", "R-MMU-6807505", "R-DRE-6807505", "R-DDI-6807505", "R-HSA-159231", "R-HSA-77595", "R-SPO-9770562", "R-DME-9770562", "R-DME-6807505", "R-MMU-72187", "R-DDI-77595", "R-BTA-9770562", "R-BTA-159231", "R-DME-73856", "R-HSA-9918481", "R-MMU-159231", "R-BTA-77595"], "pathways": ["R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DDI-9770562:r:mRNA Polyadenylation", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-72187:r:mRNA 3'-end processing", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-159231:r:Transport of Mature mRNA 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"R-HSA-9836573", "R-SCE-6791226", "R-HSA-6791226", "R-HSA-9843970", "R-CEL-9930044", "R-CEL-6791226", "R-HSA-429958", "R-CEL-72163", "R-SPO-429958", "R-SPO-72163", "R-SPO-6791226"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-9930044:r:Nuclear RNA decay", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9836573:r:Mitochondrial RNA degradation", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", 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"R-SCE-6798695", "R-SCE-9755511", "R-HSA-9755511", "R-BTA-6798695", "R-MMU-9755511", "R-XTR-6798695", "R-SPO-9755511", "R-DDI-8951664", "R-SPO-8980692", "R-MMU-8951664", "R-SCE-8951664", "R-XTR-8980692", "R-HSA-8980692", "R-SCE-8980692", "R-BTA-8980692", "R-SPO-8951664", "R-MMU-6798695", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-XTR-6798695:r:Neutrophil degranulation", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-8951664:r:Neddylation", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-8951664:r:Neddylation", "R-SCE-8951664:r:Neddylation", "R-XTR-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-SPO-8951664:r:Neddylation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR050731": {"description": "HRD1 family E3 ubiquitin-protein ligases", "go_ids": [], "go_terms": [], "name": "HRD1_E3_ubiq-ligases", "pathway_ids": ["PWY-7511", "R-HSA-381038", "R-DRE-5358346", "R-MMU-5358346", "R-HSA-901032", "R-DME-5358346", "R-CEL-5358346", "R-HSA-5358346", "R-HSA-5362768"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD"], "type": "Family"}, "IPR050732": {"description": "Beta-glucan modifying enzymes", "go_ids": [], "go_terms": [], "name": "Beta-glucan_modifiers", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050733": {"description": "Vitellogenin/Apolipophorin", "go_ids": [], "go_terms": [], "name": "Vitellogenin/Apolipophorin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050734": {"description": "PIH1 family, Kintoun subfamily", "go_ids": [], "go_terms": [], "name": "PIH1/Kintoun_subfamily", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050735": {"description": "Kininogen/Fetuin/Histidine-rich Glycoprotein", "go_ids": [], "go_terms": [], "name": "Kininogen_Fetuin_HRG", "pathway_ids": ["R-HSA-6798695", "R-HSA-375276", "R-HSA-140837", "R-MMU-75205", "R-BTA-6798695", "R-HSA-416476", "R-MMU-8957275", "R-RNO-114608", "R-RNO-418594", "R-RNO-140837", "R-BTA-8957275", "R-RNO-381426", "R-HSA-114608", "R-BTA-114608", "R-HSA-418594", "R-RNO-8957275", "R-RNO-375276", "R-MMU-381426", "R-BTA-381426", "R-MMU-6798695", "R-HSA-8957275", "R-RNO-75205", "R-RNO-416476", "R-HSA-75205", "R-HSA-381426", "R-RNO-6798695", "R-MMU-114608"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-416476:r:G alpha (q) signalling events", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-418594:r:G alpha (i) signalling events", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-RNO-416476:r:G alpha (q) signalling events", "R-HSA-75205:r:Dissolution of Fibrin Clot", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR050736": {"description": "Sensor Histidine Kinase Regulatory", "go_ids": [], "go_terms": [], "name": "Sensor_HK_Regulatory", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050738": {"description": "Sulfatase enzyme", "go_ids": [], "go_terms": [], "name": "Sulfatase", "pathway_ids": ["R-HSA-6798695", "R-RNO-9840310", "R-MMU-9840310", "R-SPO-6798695", "R-HSA-9840310", "R-CFA-2022857", "R-CFA-9840310", "R-HSA-2022857", "R-BTA-6798695", "R-HSA-1663150", "R-BTA-1663150", "R-MMU-1663150", "R-RNO-196071", "R-RNO-2022857", "R-MMU-196071", "R-MMU-2022857", "R-BTA-9840310", "R-HSA-196071", "R-MMU-6798695", "R-SPO-9840310", "R-CFA-6798695", "R-HSA-2206290", "R-CFA-1663150", "R-RNO-1663150", "R-RNO-6798695", "R-SPO-196071", "R-SPO-2022857"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-CFA-2022857:r:Keratan sulfate degradation", "R-CFA-9840310:r:Glycosphingolipid catabolism", "R-HSA-2022857:r:Keratan sulfate degradation", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-1663150:r:The activation of arylsulfatases", "R-BTA-1663150:r:The activation of arylsulfatases", "R-MMU-1663150:r:The activation of arylsulfatases", "R-RNO-196071:r:Metabolism of steroid hormones", "R-RNO-2022857:r:Keratan sulfate degradation", "R-MMU-196071:r:Metabolism of steroid hormones", "R-MMU-2022857:r:Keratan sulfate degradation", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-HSA-196071:r:Metabolism of steroid hormones", "R-MMU-6798695:r:Neutrophil degranulation", "R-SPO-9840310:r:Glycosphingolipid catabolism", "R-CFA-6798695:r:Neutrophil degranulation", "R-HSA-2206290:r:MPS IV - Morquio syndrome A", "R-CFA-1663150:r:The activation of arylsulfatases", "R-RNO-1663150:r:The activation of arylsulfatases", "R-RNO-6798695:r:Neutrophil degranulation", "R-SPO-196071:r:Metabolism of steroid hormones", "R-SPO-2022857:r:Keratan sulfate degradation"], "type": "Family"}, "IPR050739": {"description": "Membrane Fusion Protein", "go_ids": [], "go_terms": [], "name": "MFP", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Family"}, "IPR050740": {"description": "Aldehyde Dehydrogenase Superfamily", "go_ids": [], "go_terms": [], "name": "Aldehyde_DH_Superfamily", "pathway_ids": ["R-RNO-916853", "R-SPO-916853", "R-HSA-916853", "R-SCE-916853", "R-MMU-916853"], "pathways": ["R-RNO-916853:r:Degradation of GABA", "R-SPO-916853:r:Degradation of GABA", "R-HSA-916853:r:Degradation of GABA", "R-SCE-916853:r:Degradation of GABA", "R-MMU-916853:r:Degradation of GABA"], "type": "Family"}, "IPR050743": {"description": "2-oxoacid dehydrogenase family, E2 component", "go_ids": [], "go_terms": [], "name": "2-oxoacid_DH_E2_comp", "pathway_ids": ["R-BTA-9013407", "R-BTA-70895", "R-MMU-9013407", "R-MMU-9837999", "R-CEL-9837999", "R-MMU-9857492", "R-HSA-9865125", "R-BTA-9857492", "R-HSA-9907570", "R-HSA-70895", "R-HSA-9857492", "R-CEL-9013407", "R-CEL-9857492", "R-MMU-70895", "R-MMU-9859138", "R-BTA-9859138", "R-BTA-9837999", "R-HSA-1222541", "R-HSA-9859138", "R-HSA-9837999", "R-HSA-9865113", "R-HSA-9912481", "R-CEL-9859138", "R-HSA-9912529", "R-HSA-9013407"], "pathways": ["R-BTA-9013407:r:RHOH GTPase cycle", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-MMU-9857492:r:Protein lipoylation", "R-HSA-9865125:r:Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD", "R-BTA-9857492:r:Protein lipoylation", "R-HSA-9907570:r:Loss-of-function mutations in DLD cause MSUD3/DLDD", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9857492:r:Protein lipoylation", "R-CEL-9013407:r:RHOH GTPase cycle", "R-CEL-9857492:r:Protein lipoylation", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-MMU-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-HSA-1222541:r:Cell redox homeostasis", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-CEL-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR050744": {"description": "AI-2 Signaling Cycle Isomerase LsrG", "go_ids": [], "go_terms": [], "name": "AI-2_Isomerase_LsrG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050745": {"description": "Multifunctional regulatory proteins", "go_ids": [], "go_terms": [], "name": "Multifunctional_regulatory", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050746": {"description": "Dicarboxylate/Amino Acid:Cation Symporter", "go_ids": [], "go_terms": [], "name": "DAACS", "pathway_ids": ["R-HSA-9013409", "R-BTA-210500", "R-MMU-210455", "R-CEL-352230", "R-HSA-5619067", "R-CEL-210500", "R-RNO-9013149", "R-BTA-9013406", "R-BTA-352230", "R-MMU-9958863", "R-MMU-352230", "R-RNO-210455", "R-CEL-9013149", "R-HSA-9013423", "R-CEL-9013407", "R-BTA-9013423", "R-HSA-352230", "R-RNO-352230", "R-BTA-210455", "R-HSA-210455", "R-CEL-9013406", "R-RNO-9013406", "R-HSA-210500", "R-HSA-5619062", "R-CEL-9013423", "R-BTA-9013407", "R-MMU-9013407", "R-RNO-210500", "R-RNO-9013407", "R-MMU-210500", "R-HSA-9958863", "R-BTA-9958863", "R-RNO-9958863", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013149", "R-CEL-210455", "R-MMU-9013406", "R-CEL-9958863", "R-HSA-9013406", "R-MMU-9013149", "R-HSA-9013407"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-BTA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-352230:r:Amino acid transport across the plasma membrane", "R-HSA-5619067:r:Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-BTA-352230:r:Amino acid transport across the plasma membrane", "R-MMU-9958863:r:SLC-mediated transport of amino acids", "R-MMU-352230:r:Amino acid transport across the plasma membrane", "R-RNO-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-9013407:r:RHOH GTPase cycle", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-352230:r:Amino acid transport across the plasma membrane", "R-RNO-352230:r:Amino acid transport across the plasma membrane", "R-BTA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-HSA-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-5619062:r:Defective SLC1A3 causes episodic ataxia 6 (EA6)", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-BTA-9013407:r:RHOH GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-9958863:r:SLC-mediated transport of amino acids", "R-BTA-9958863:r:SLC-mediated transport of amino acids", "R-RNO-9958863:r:SLC-mediated transport of amino acids", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-CEL-210455:r:Astrocytic Glutamate-Glutamine Uptake And Metabolism", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-CEL-9958863:r:SLC-mediated transport of amino acids", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR050747": {"description": "Mitochondrial chaperone BCS1 subfamily", "go_ids": [], "go_terms": [], "name": "Mitochondrial_chaperone_BCS1", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-1268020", "R-HSA-9865881"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-1268020:r:Mitochondrial protein import", "R-HSA-9865881:r:Complex III assembly"], "type": "Family"}, "IPR050748": {"description": "Glycosyltransferase 8 domain-containing", "go_ids": [], "go_terms": [], "name": "Glycosyltrans_8_dom-fam", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR050749": {"description": "Glycosyl Hydrolase Family 47", "go_ids": [], "go_terms": [], "name": "Glycosyl_Hydrolase_47", "pathway_ids": ["PWY-7919", "R-HSA-901032", "R-HSA-6811438", "R-CEL-964827", "R-DME-964827", "R-MMU-964827", "R-HSA-4793950", "R-HSA-964827", "R-HSA-9694548"], "pathways": ["PWY-7919:t:protein N-glycosylation processing phase (plants and animals)", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-HSA-6811438:r:Intra-Golgi traffic", "R-CEL-964827:r:Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2", "R-DME-964827:r:Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2", "R-MMU-964827:r:Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2", "R-HSA-4793950:r:Defective MAN1B1 causes MRT15", "R-HSA-964827:r:Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2", "R-HSA-9694548:r:Maturation of spike protein"], "type": "Family"}, "IPR050750": {"description": "Cytosine-specific C5-methyltransferase", "go_ids": [], "go_terms": [], "name": "C5-MTase", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR050751": {"description": "Extracellular matrix structural protein", "go_ids": [], "go_terms": [], "name": "ECM_structural_protein", "pathway_ids": ["R-HSA-2129379", "R-HSA-2173789", "R-MMU-2173789", "R-HSA-8957275", "R-MMU-1566948", "R-RNO-2173789", "R-HSA-381426", "R-RNO-2129379", "R-MMU-2129379"], "pathways": ["R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-1566948:r:Elastic fibre formation", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Family"}, "IPR050752": {"description": "C2H2-type zinc-finger domain-containing protein", "go_ids": [], "go_terms": [], "name": "C2H2-ZF_domain", "pathway_ids": ["R-HSA-9843940", "R-MMU-212436", "R-HSA-212436", "R-BTA-212436"], "pathways": ["R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway", "R-BTA-212436:r:Generic Transcription Pathway"], "type": "Family"}, "IPR050753": {"description": "Peptidase M14 domain-containing protein", "go_ids": [], "go_terms": [], "name": "Peptidase_M14_domain", "pathway_ids": ["R-MMU-163125", "R-MMU-977606", "R-HSA-977606", "R-HSA-264876", "R-MMU-432722", "R-RNO-9696264", "R-RNO-977606", "R-MMU-9696264", "R-MMU-9696273", "R-HSA-432722", "R-RNO-9696273", "R-RNO-432722", "R-HSA-9696273", "R-HSA-9696264", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-264876:r:Insulin processing", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9696264:r:RND3 GTPase cycle", "R-RNO-977606:r:Regulation of Complement cascade", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Family"}, "IPR050754": {"description": "Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like", "go_ids": [], "go_terms": [], "name": "FKBP4/5/8-like", "pathway_ids": ["R-HSA-3371568", "R-MMU-8939211", "R-MMU-9909505", "R-HSA-5689880", "R-MMU-8852276", "R-DME-3371497", "R-DME-9018519", "R-HSA-8852276", "R-RNO-9909505", "R-RNO-3371497", "R-HSA-9679191", "R-HSA-3371497", "R-RNO-9018519", "R-RNO-5689880", "R-HSA-9909505", "R-MMU-9018519", "R-MMU-5689880", "R-RNO-3371568", "R-DME-3371568", "R-DME-9909505", "R-MMU-3371568", "R-HSA-8939211", "R-HSA-9022699", "R-RNO-8852276", "R-DME-8939211", "R-RNO-8939211", "R-HSA-9018519", "R-PFA-3371497", "R-MMU-3371497"], "pathways": ["R-HSA-3371568:r:Attenuation phase", "R-MMU-8939211:r:ESR-mediated signaling", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-RNO-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-RNO-5689880:r:Ub-specific processing proteases", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-MMU-5689880:r:Ub-specific processing proteases", "R-RNO-3371568:r:Attenuation phase", "R-DME-3371568:r:Attenuation phase", "R-DME-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-3371568:r:Attenuation phase", "R-HSA-8939211:r:ESR-mediated signaling", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-RNO-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-DME-8939211:r:ESR-mediated signaling", "R-RNO-8939211:r:ESR-mediated signaling", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "type": "Family"}, "IPR050755": {"description": "TRAFAC YlqF/YawG GTPases, Ribosome Maturation", "go_ids": [], "go_terms": [], "name": "TRAFAC_YlqF/YawG_RiboMat", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DRE-6791226", "R-DME-6791226", "R-CEL-6791226", "R-SPO-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR050756": {"description": "COP9 signalosome complex subunit 3", "go_ids": [], "go_terms": [], "name": "CSN3", "pathway_ids": ["R-HSA-174178", "R-HSA-9604323", "R-BTA-5689880", "R-HSA-8951664", "R-BTA-9755511", "R-HSA-9010553", "R-HSA-75815", "R-CEL-8941858", "R-MMU-8948751", "R-DME-8948751", "R-XTR-5696394", "R-DME-5696394", "R-SPO-5689880", "R-MMU-5689880", "R-CEL-1234176", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-DME-5676590", "R-MMU-5696394", "R-HSA-450408", "R-CEL-5696394", "R-SCE-5689880", "R-HSA-211733", "R-DDI-6798695", "R-DME-4641257", "R-HSA-5607761", "R-DME-432524", "R-DDI-174084", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-DDI-5696394", "R-BTA-69017", "R-HSA-180534", "R-BTA-4641257", "R-CEL-8948751", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-DDI-187577", "R-DDI-382556", "R-DME-202424", "R-MMU-187577", "R-DME-187577", "R-BTA-1236978", "R-HSA-9824272", "R-MMU-174178", "R-BTA-4608870", "R-BTA-5676590", "R-MMU-349425", "R-DME-350562", "R-HSA-9907900", "R-CEL-8854050", "R-DME-174084", "R-BTA-2871837", "R-BTA-174154", "R-DDI-69601", "R-DME-9929491", "R-HSA-9762114", "R-DDI-5689880", "R-HSA-195253", "R-BTA-187577", "R-GGA-8856825", "R-CEL-9755511", "R-BTA-5696394", "R-DME-6798695", "R-DME-8939236", "R-DME-174184", "R-BTA-9929356", "R-MMU-5676590", "R-MMU-174184", "R-HSA-8856825", "R-DME-9932298", "R-BTA-9954709", "R-DME-9020702", "R-CEL-9762114", "R-DME-5689880", "R-SPO-350562", "R-HSA-5358346", "R-CEL-8951664", "R-HSA-6798695", "R-MMU-5632684", "R-SPO-9907900", "R-BTA-5610785", "R-BTA-202424", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-BTA-6798695", "R-DDI-1236978", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-8951664", "R-DME-8939902", "R-CEL-5689603", "R-CEL-382556", "R-MMU-9929356", "R-DME-4608870", "R-SCE-5668541", "R-HSA-69481", "R-DME-9762114", "R-BTA-174084", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DDI-6781823", "R-HSA-4641258", "R-DRE-5696394", "R-SPO-5689603", "R-DME-1236978", "R-CEL-6781823", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-DME-8941858", "R-SPO-6798695", "R-MMU-5610780", "R-DME-9954709", "R-BTA-382556", "R-CEL-8939902", "R-MMU-9755511", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-HSA-5362768", "R-DME-5689603", "R-DDI-9954709", "R-DME-216167", "R-MMU-5658442", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-BTA-8948751", "R-RNO-8856825", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-BTA-8856825", "R-DDI-349425", "R-HSA-69017", "R-BTA-9020702", "R-BTA-5607764", "R-DDI-450408", "R-MMU-1236978", "R-CEL-350562", "R-HSA-202424", "R-CEL-4641257", "R-DDI-174154", "R-RNO-6781823", "R-MMU-450408", "R-HSA-9020702", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-MMU-174154", "R-BTA-1234176", "R-MMU-69017", "R-MMU-9020702", "R-DME-5658442", "R-CEL-195253", "R-MMU-69481", "R-BTA-350562", "R-DDI-8856825", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-BTA-68867", "R-HSA-1234176", "R-HSA-9931269", "R-MMU-68867", "R-HSA-9929491", "R-DME-209461", "R-RNO-5696394", "R-DME-75815", "R-RNO-8951664", "R-HSA-5696394", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-MMU-5687128", "R-XTR-6781823", "R-CEL-8856825", "R-DME-5358346", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-HSA-2467813", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-GGA-8951664", "R-CEL-9907900", "R-CEL-983168", "R-MMU-8939236", "R-BTA-6781823", "R-MMU-6781823", "R-DME-9907900", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-BTA-174184", "R-MMU-9762114", "R-DRE-6781823", "R-MMU-195253", "R-MMU-202424", "R-MMU-382556", "R-HSA-5610780", "R-BTA-8939236", "R-DME-209360", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-MMU-1169091", "R-DME-432626", "R-GGA-5696394", "R-XTR-8951664", "R-MMU-5607761", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-MMU-8939902", "R-DME-174178", "R-HSA-8939236", "R-DDI-8854050", "R-BTA-983168", "R-MMU-5607764", "R-DME-6781823", "R-DME-8951664", "R-DRE-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577", "R-HSA-5676590", "R-DDI-5632684", "R-BTA-9929491", "R-HSA-4641257", "R-MMU-9929491", "R-HSA-174113", "R-BTA-9932298", "R-BTA-9762114", "R-GGA-6781823", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-CEL-4641258", "R-DDI-5658442", "R-BTA-450408", "R-HSA-8941858", "R-HSA-9755511", "R-CEL-9929491", "R-DME-9755511", "R-HSA-1169091", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-HSA-5689603", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DME-1169091", "R-DDI-9755511", "R-MMU-8856825", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-BTA-8941858", "R-DME-4641258", "R-HSA-174184", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-DME-68949", "R-DRE-8856825", "R-DME-8856825", "R-CEL-1236978", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-69601", "R-DME-5632684", "R-HSA-5687128", "R-CEL-68949", "R-DME-432395", "R-MMU-983168", "R-HSA-350562", "R-DDI-174178", "R-DME-68867"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-XTR-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-4641257:r:Degradation of AXIN", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-432524:r:Degradation of PER", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DME-202424:r:Downstream TCR signaling", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9907900:r:Proteasome assembly", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-5689880:r:Ub-specific processing proteases", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-4641258:r:Degradation of DVL", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5689603:r:UCH proteinases", "R-DME-1236978:r:Cross-presentation of soluble 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"R-CFA-8875555:r:MET activates RAP1 and RAC1", "R-RNO-8875656:r:MET receptor recycling", "R-RNO-8851805:r:MET activates RAS signaling", "R-CFA-6806942:r:MET Receptor Activation", "R-CFA-8875656:r:MET receptor recycling", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-RNO-8875555:r:MET activates RAP1 and RAC1", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-186797:r:Signaling by PDGF", "R-HSA-8865999:r:MET activates PTPN11", "R-CFA-8875791:r:MET activates STAT3", "R-RNO-8851907:r:MET activates PI3K/AKT signaling", "R-MMU-114608:r:Platelet degranulation", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-9734091:r:Drug-mediated inhibition of MET activation", "R-RNO-114608:r:Platelet degranulation", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8852405:r:Signaling by MST1", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-HSA-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-75205:r:Dissolution of Fibrin Clot", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-9734091:r:Drug-mediated inhibition of MET activation", "R-HSA-8875791:r:MET activates STAT3", "R-HSA-8852405:r:Signaling by MST1", "R-CFA-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-1592389:r:Activation of Matrix Metalloproteinases", "R-RNO-8875791:r:MET activates STAT3", "R-RNO-186797:r:Signaling by PDGF", "R-MMU-75205:r:Dissolution of Fibrin Clot", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-6807004:r:Negative regulation of MET activity", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-8964041:r:LDL remodeling", "R-RNO-6807004:r:Negative regulation of MET activity", "R-MMU-6806942:r:MET Receptor Activation", "R-CFA-8865999:r:MET activates PTPN11", "R-MMU-8851907:r:MET activates PI3K/AKT signaling", "R-CFA-75205:r:Dissolution of Fibrin Clot", "R-MMU-8875656:r:MET receptor recycling", "R-MMU-6807004:r:Negative regulation of MET activity", "R-HSA-8875656:r:MET receptor recycling"], "type": "Family"}, "IPR050760": {"description": "Period circadian regulator", "go_ids": [], "go_terms": [], "name": "Period_circadian_regulator", "pathway_ids": ["R-HSA-9931510", "R-DME-432620", "R-DME-432524", "R-DME-538898", "R-RNO-9932298", "R-DME-432553", "R-HSA-9931530", "R-DME-432395", "R-DME-9932298", "R-MMU-9932298", "R-HSA-9932298", "R-DME-432490", "R-HSA-9931521", "R-DME-432501"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-DME-432620:r:Dephosphorylation of PER", "R-DME-432524:r:Degradation of PER", "R-DME-538898:r:Dephosphorylation of TIM", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-DME-432395:r:Degradation of TIM", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DME-432490:r:Nuclear import of PER and TIM", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-DME-432501:r:Transcription repression by PER and activation by PDP1"], "type": "Family"}, "IPR050762": {"description": "HD-ZIP Homeobox Leucine Zipper Class II", "go_ids": [], "go_terms": [], "name": "HD-ZIP_Homeobox_LZ_Class_II", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050763": {"description": "ABC transporter ATP-binding component", "go_ids": [], "go_terms": [], "name": "ABC_transporter_ATP-binding", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050764": {"description": "CbbQ/NirQ/NorQ/GpvN", "go_ids": [], "go_terms": [], "name": "CbbQ/NirQ/NorQ/GpvN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050765": {"description": "Riboflavin Biosynthesis HTP Reductase", "go_ids": [], "go_terms": [], "name": "Riboflavin_Biosynth_HTPR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050766": {"description": "Bacterial Luciferase Oxidoreductase", "go_ids": [], "go_terms": [], "name": "Bact_Lucif_Oxidored", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050767": {"description": "Sel1/AlgK", "go_ids": [], "go_terms": [], "name": "Sel1_AlgK", "pathway_ids": ["R-HSA-1912420", "R-MMU-382556", "R-HSA-9931269", "R-HSA-901032", "R-MMU-5358346", "R-MMU-9931269", "R-HSA-382556", "R-HSA-5362768", "R-HSA-5678895", "R-RNO-9931269", "R-RNO-382556", "R-RNO-5358346", "R-HSA-5358346"], "pathways": ["R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-RNO-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-RNO-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Family"}, "IPR050768": {"description": "UPF0353/GerABKA protein families", "go_ids": [], "go_terms": [], "name": "UPF0353/GerABKA_families", "pathway_ids": ["R-HSA-73856", "R-HSA-159236", "R-HSA-72187"], "pathways": ["R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-72187:r:mRNA 3'-end processing"], "type": "Family"}, "IPR050769": {"description": 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"PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-8963693", "R-HSA-977225", "R-XTR-8963693", "R-DRE-8963693", "R-RNO-8963693", "R-MMU-8963693"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-HSA-977225:r:Amyloid fiber formation", "R-XTR-8963693:r:Aspartate and asparagine metabolism", "R-DRE-8963693:r:Aspartate and asparagine metabolism", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-MMU-8963693:r:Aspartate and asparagine metabolism"], "type": "Family"}, "IPR050770": {"description": "Intradiol Ring-Cleavage Dioxygenase", "go_ids": [], "go_terms": [], "name": "Intradiol_RC_Dioxygenase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050771": {"description": "Alpha-ketoacid dehydrogenase complex E1 component", "go_ids": [], "go_terms": [], "name": "Alpha-ketoacid_DH_E1_comp", "pathway_ids": ["R-DDI-9859138", "R-RNO-9859138", "R-MMU-9859138", "R-MMU-70895", "R-HSA-9865125", "R-HSA-9912481", "R-CEL-9859138", "R-HSA-70895", "R-HSA-9907570", "R-HSA-9865113", "R-HSA-9912529", "R-HSA-9859138", "R-RNO-70895"], "pathways": ["R-DDI-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-RNO-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-MMU-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-HSA-9865125:r:Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD", "R-HSA-9912481:r:Branched-chain ketoacid dehydrogenase kinase deficiency", "R-CEL-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9907570:r:Loss-of-function mutations in DLD cause MSUD3/DLDD", "R-HSA-9865113:r:Loss-of-function mutations in DBT cause MSUD2", "R-HSA-9912529:r:H139Hfs13* PPM1K causes a mild variant of MSUD", "R-HSA-9859138:r:BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Family"}, "IPR050772": {"description": "Hydratase/Decarboxylase Family, MhpD Subfamily", "go_ids": [], "go_terms": [], "name": "Hydratase-Decarb/MhpD_sf", "pathway_ids": ["PWY-5645", "PWY-5162"], "pathways": ["PWY-5645:t:4-chloronitrobenzene degradation", "PWY-5162:t:2-hydroxypenta-2,4-dienoate degradation"], "type": "Family"}, "IPR050773": {"description": "CbxX/CfxQ RuBisCO activation and ESX secretion", "go_ids": [], "go_terms": [], "name": "CbxX/CfxQ_RuBisCO_ESX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050774": {"description": "KCMF1 and Dystrophin", "go_ids": [], "go_terms": [], "name": "KCMF1/Dystrophin", "pathway_ids": ["R-HSA-6798695", "R-CEL-9913351", "R-RNO-390522", "R-DME-6798695", "R-CEL-6798695", "R-DME-114608", "R-MMU-390522", "R-HSA-9913351", "R-HSA-3000171", "R-HSA-9619665", "R-DME-9013418", "R-RNO-9913351", "R-DME-9035034", "R-MMU-9913351", "R-DRE-6798695", "R-DME-446388", "R-HSA-390522", "R-MMU-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-RNO-390522:r:Striated Muscle Contraction", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-114608:r:Platelet degranulation", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DME-9035034:r:RHOF GTPase cycle", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-DRE-6798695:r:Neutrophil degranulation", "R-DME-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-390522:r:Striated Muscle Contraction", "R-MMU-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR050775": {"description": "Baeyer-Villiger monooxygenase-like", "go_ids": [], "go_terms": [], "name": "Baeyer-Villiger_monooxygenase", "pathway_ids": ["PWY-5882", "PWY-6526", "PWY-7045", "PWY-5871", "PWY-7626", "PWY-5856", "PWY-7989", "PWY-5421", "PWY-6495", "PWY-6340", "PWY-5855", "PWY-7689", "PWY-7677", "PWY-7151", "PWY-7412", "PWY-6378", "PWY-7010", "PWY-7692", "PWY-6379", "PWY-2467", "PWY-7615", "PWY-7757", "PWY-8049", "PWY-5857", "PWY-7624", "PWY-7659", "PWY-7565", "PWY-5318", "PWY-7150", "PWY-7667", "PWY-5706", "PWY-7983", "PWY-7604", "PWY-7212", "PWY-7895", "PWY-8100", "PWY-8374", "PWY-7629", "PWY-5873", "PWY-7230", "PWY-8432", "PWY-7733", "PWY-8012", "PWY-7984", "PWY-7009", "PWY-6831", "PWY-7861", "PWY-8038", "PWY-2724", "PWY-581", "PWY-8158", "PWY-7419", "PWY-6503", "PWY-7175", "PWY-7521", "PWY-7668", "PWY-7603", "PWY-7650", "PWY-8382", "PWY-7673", "PWY-7734", "PWY-7779", "PWY-7430", "PWY-7705", "PWY-5984", "PWY-5412", "PWY-7687", "PWY-8087", "PWY-321", "PWY-8036", "PWY-7660", "PWY-7407", "PWY-7599", "PWY-7988", "PWY-7698", "PWY-2421", "PWY-7513", "PWY-8111", "PWY-5434", "PWY-6552", "PWY-7826", "PWY-7937", "PWY-5870", "PWY-7638", "PWY-5413", "PWY-8035", "PWY-5414", "PWY-7949", "PWY-7749", "PWY-1381", "PWY-7085", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-7304", "PWY-7492", "PWY-6978", "PWY-5422", "PWY-6708", "PWY-5846", "PWY-7405", "PWY-6710", "PWY-7011", "PWY-7481", "PWY-5872", "PWY-7648", "PWY-7637", "PWY-601", "PWY-761", "PWY-7775", "PWY-7708", "PWY-6971", "PWY-8085", "PWY-7780", "PWY-7703"], "pathways": ["PWY-5882:t:epoxypseudoisoeugenol-2-methylbutanoate biosynthesis", "PWY-6526:t:limonene degradation III (to perillate)", "PWY-7045:t:mithramycin biosynthesis", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-7626:t:bacilysin biosynthesis", "PWY-5856:t:ubiquinol-9 biosynthesis (early decarboxylation)", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-5421:t:dehydroabietic acid biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-6340:t:5,5'-dehydrodivanillate degradation", "PWY-5855:t:ubiquinol-7 biosynthesis (early decarboxylation)", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7010:t:2-propylphenol degradation", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-2467:t:(+)-pisatin biosynthesis", "PWY-7615:t:pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)", "PWY-7757:t:bisphenol A degradation", "PWY-8049:t:pederin biosynthesis", "PWY-5857:t:ubiquinol-10 biosynthesis (early decarboxylation)", "PWY-7624:t:nystatin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-5706:t:alliin metabolism", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7604:t:notoamide C and D biosynthesis", "PWY-7212:t:baicalein metabolism", "PWY-7895:t:ethionamide activation", "PWY-8100:t:crotonosine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-7629:t:yatein biosynthesis II", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7009:t:2,2'-dihydroxybiphenyl degradation", "PWY-6831:t:pyrrolnitrin biosynthesis", "PWY-7861:t:N-hydroxy-L-pipecolate biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-2724:t:alkane oxidation", "PWY-581:t:indole-3-acetate biosynthesis II", "PWY-8158:t:ibotenate and muscimol biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6503:t:superpathway of ergotamine biosynthesis", "PWY-7175:t:nostoxanthin biosynthesis", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation", "PWY-7668:t:apicidin F biosynthesis", "PWY-7603:t:stephacidin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-7705:t:quinolinone B biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-5412:t:levopimaric acid biosynthesis", "PWY-7687:t:stipitatate biosynthesis", "PWY-8087:t:indole-3-acetate degradation II", "PWY-321:t:cutin biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7698:t:2,5-xylenol and 3,5-xylenol degradation", "PWY-2421:t:indole-3-acetate degradation I", "PWY-7513:t:flaviolin dimer and mompain biosynthesis", "PWY-8111:t:carbaryl degradation", "PWY-5434:t:(3E)-4,8-dimethylnona-1,3,7-triene biosynthesis I", "PWY-6552:t:caffeine degradation I (main, plants)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7937:t:fungal bioluminescence", "PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-7638:t:echinenone and zeaxanthin biosynthesis (Synechocystis)", "PWY-5413:t:neoabietic acid biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5414:t:palustric acid biosynthesis", "PWY-7949:t:diadinoxanthin and diatoxanthin interconversion", "PWY-7749:t:(-)-4'-demethyl-epipodophyllotoxin biosynthesis", "PWY-1381:t:fluorene degradation II", "PWY-7085:t:triethylamine degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-7304:t:3-amino-4,7-dihydroxy-coumarin biosynthesis", "PWY-7492:t:paspaline biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-5422:t:isopimaric acid biosynthesis", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5846:t:colchicine biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6710:t:poly-hydroxy fatty acids biosynthesis", "PWY-7011:t:2-isopropylphenol degradation", "PWY-7481:t:oryzalide A biosynthesis", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-7637:t:2,2'-dihydroxyketocarotenoids biosynthesis", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7775:t:propane degradation II", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-7780:t:butane degradation", "PWY-7703:t:2,4-xylenol degradation to protocatechuate"], "type": "Family"}, "IPR050776": {"description": "Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor", "go_ids": [], "go_terms": [], "name": "Ank_Repeat/CDKN_Inhibitor", "pathway_ids": ["R-HSA-8853884", "R-RNO-2559585", "R-BTA-69231", "R-RNO-2559582", "R-HSA-2559580", "R-HSA-9632697", "R-BTA-2559580", "R-BTA-2559582", "R-BTA-2559585", "R-HSA-2559585", "R-MMU-2559582", "R-HSA-2559582", "R-HSA-69231", "R-MMU-2559580", "R-RNO-69231", "R-HSA-9632700", "R-RNO-2559580", "R-HSA-9630791", "R-HSA-9825892", "R-HSA-2173796", "R-MMU-2559585", "R-HSA-9630794", "R-MMU-69231"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-RNO-2559585:r:Oncogene Induced Senescence", "R-BTA-69231:r:Cyclin D associated events in G1", "R-RNO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9632697:r:Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-BTA-2559585:r:Oncogene Induced Senescence", "R-HSA-2559585:r:Oncogene Induced Senescence", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-69231:r:Cyclin D associated events in G1", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-9632700:r:Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-9630791:r:Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4", "R-HSA-9825892:r:Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-MMU-2559585:r:Oncogene Induced Senescence", "R-HSA-9630794:r:Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Family"}, "IPR050777": {"description": "SET2 Histone-Lysine N-Methyltransferase", "go_ids": [], "go_terms": [], "name": "SET2_Histone-Lys_MeTrsfase", "pathway_ids": ["R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-MMU-3214841", "R-HSA-3214841", "R-HSA-69473", "R-HSA-5693565", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Family"}, "IPR050779": {"description": "Protein-glutamine gamma-glutamyltransferases", "go_ids": [], "go_terms": [], "name": "Transglutaminase", "pathway_ids": ["R-HSA-114608", "R-RNO-6809371", "R-MMU-6809371", "R-HSA-6809371", "R-MMU-140875", "R-RNO-140875", "R-HSA-6785807", "R-HSA-140875", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-RNO-6809371:r:Formation of the cornified envelope", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR050780": {"description": "Mucin/von Willebrand/Thrombospondin superfamily", "go_ids": [], "go_terms": [], "name": "Mucin_vWF_Thrombospondin_sf", "pathway_ids": ["R-HSA-5083632", "R-HSA-5674135", "R-MMU-5674135", "R-HSA-6802952", "R-HSA-9845620", "R-HSA-977068", "R-MMU-913709", "R-HSA-140837", "R-HSA-430116", "R-MMU-76009", "R-MMU-430116", "R-HSA-9845622", "R-HSA-9845621", "R-MMU-372708", "R-HSA-114608", "R-HSA-76009", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-9846298", "R-HSA-5083625", "R-HSA-9672391", "R-MMU-977068", "R-HSA-5621480", "R-HSA-6802955", "R-HSA-9672393", "R-HSA-354192", "R-HSA-5083636", "R-HSA-6802948", "R-HSA-216083", "R-HSA-5083635", "R-HSA-9662361", "R-MMU-140837", "R-HSA-9845619", "R-HSA-354194", "R-MMU-354194", "R-HSA-75892", "R-RNO-5173214", "R-MMU-114608", "R-HSA-5173214", "R-MMU-5173214", "R-MMU-216083", "R-HSA-372708", "R-MMU-354192", "R-HSA-913709", "R-HSA-9656223"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-354192:r:Integrin signaling", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-RNO-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-114608:r:Platelet degranulation", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Family"}, "IPR050781": {"description": "Pre-mRNA-splicing factor CWC22", "go_ids": [], "go_terms": [], "name": "CWC22_splicing_factor", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-DME-72163", "R-CEL-72163", "R-SPO-72163", "R-HSA-9918481", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR050782": {"description": "Protein phosphatase 1 regulatory subunit 3", "go_ids": [], "go_terms": [], "name": "PP1_regulatory_subunit_3", "pathway_ids": ["R-SCE-3322077", "R-HSA-3785653", "R-BTA-3322077", "R-MMU-3322077", "R-DRE-3322077", "R-DME-3322077", "R-RNO-3322077", "R-HSA-3322077"], "pathways": ["R-SCE-3322077:r:Glycogen synthesis", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-BTA-3322077:r:Glycogen synthesis", "R-MMU-3322077:r:Glycogen synthesis", "R-DRE-3322077:r:Glycogen synthesis", "R-DME-3322077:r:Glycogen synthesis", "R-RNO-3322077:r:Glycogen synthesis", "R-HSA-3322077:r:Glycogen synthesis"], "type": "Family"}, "IPR050783": {"description": "Oxylipin biosynthesis and metabolism", "go_ids": [], "go_terms": [], "name": "Oxylipin_biosynth_metab", "pathway_ids": ["R-HSA-2162123", "R-GGA-9027604", "R-GGA-9018679", "R-GGA-2162123", "R-RNO-2162123", "R-MMU-2162123", "R-HSA-9018679", "R-MMU-9027604", "R-MMU-9025094", "R-RNO-9025094", "R-RNO-2142770", "R-HSA-6785807", "R-GGA-2142770", "R-MMU-2142770", "R-CFA-2162123", "R-HSA-140180", "R-GGA-9025094", "R-GGA-9018677", "R-HSA-9025094", "R-CFA-140180", "R-MMU-9018679", "R-HSA-9027604", "R-MMU-140180", "R-RNO-9018677", "R-RNO-140180", "R-RNO-9027604", "R-HSA-9018677", "R-HSA-2142770", "R-HSA-6783783", "R-RNO-9018679", "R-MMU-9018677"], "pathways": ["R-HSA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-GGA-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-GGA-9018679:r:Biosynthesis of EPA-derived SPMs", "R-GGA-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-RNO-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-MMU-2162123:r:Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "R-HSA-9018679:r:Biosynthesis of EPA-derived SPMs", "R-MMU-9027604:r:Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives", "R-MMU-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-RNO-9025094:r:Biosynthesis of DPAn-3 SPMs", "R-RNO-2142770:r:Synthesis of 15-eicosatetraenoic acid derivatives", "R-HSA-6785807:r:Interleukin-4 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"R-MMU-9018677:r:Biosynthesis of DHA-derived SPMs"], "type": "Family"}, "IPR050784": {"description": "Inhibitor of Apoptosis", "go_ids": [], "go_terms": [], "name": "IAP", "pathway_ids": ["R-RNO-8948751", "R-HSA-168638", "R-SSC-5357786", "R-HSA-5689880", "R-RNO-5357905", "R-SSC-5357905", "R-MMU-8948751", "R-DME-8948751", "R-MMU-111459", "R-CFA-5676594", "R-MMU-5689880", "R-DME-390150", "R-DME-111465", "R-HSA-168927", "R-CFA-937041", "R-MMU-5668541", "R-DME-8948747", "R-HSA-937041", "R-HSA-9824594", "R-HSA-111463", "R-HSA-111459", "R-SSC-5675482", "R-HSA-5675482", "R-CFA-5357786", "R-MMU-8948747", "R-HSA-5357786", "R-SSC-5676594", "R-DME-3769402", "R-RNO-9627069", "R-MMU-5357905", "R-DME-209447", "R-HSA-8948751", "R-RNO-111463", "R-HSA-111469", "R-MMU-5676594", "R-CFA-5668541", "R-HSA-3769402", "R-HSA-5676594", "R-CFA-5675482", "R-DME-111469", "R-MMU-5357956", "R-CFA-5689880", "R-HSA-5357905", "R-MMU-9627069", "R-MMU-111464", "R-CFA-168638", "R-SSC-5689880", "R-DME-111459", "R-MMU-168638", "R-HSA-9627069", "R-CFA-5357956", "R-MMU-111465", "R-RNO-111464", "R-RNO-8948747", "R-MMU-3769402", "R-SSC-5668541", "R-MMU-5357786", "R-MMU-111463", "R-HSA-8948747", "R-DME-9627069", "R-MMU-5675482", "R-DME-5675482", "R-HSA-111464", "R-RNO-111459", "R-RNO-111469", "R-SSC-5357956", "R-SSC-937041", "R-MMU-111469", "R-HSA-5213460", "R-HSA-5668541", "R-HSA-5357956", "R-HSA-111465", "R-RNO-5357956", "R-RNO-5675482", "R-RNO-3769402", "R-RNO-5357786", "R-CFA-5357905", "R-MMU-937041"], "pathways": ["R-RNO-8948751:r:Regulation of PTEN stability and activity", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-SSC-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-SSC-5357905:r:Regulation of TNFR1 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-111459:r:Activation of caspases through 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"R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-SSC-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-DME-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-CFA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-CFA-5675482:r:Regulation of necroptotic cell death", "R-DME-111469:r:SMAC, XIAP-regulated apoptotic response", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-CFA-5689880:r:Ub-specific processing proteases", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-MMU-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-SSC-5689880:r:Ub-specific processing proteases", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-CFA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-RNO-8948747:r:Regulation of PTEN localization", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-SSC-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-8948747:r:Regulation of PTEN localization", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-DME-5675482:r:Regulation of necroptotic cell death", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-RNO-111469:r:SMAC, XIAP-regulated apoptotic response", "R-SSC-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-SSC-937041:r:IKK complex recruitment mediated by RIP1", "R-MMU-111469:r:SMAC, XIAP-regulated apoptotic response", "R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-CFA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1"], "type": "Family"}, "IPR050785": {"description": "PAN2-PAN3 complex catalytic subunit", "go_ids": [], "go_terms": [], "name": "PAN2-PAN3_catalytic_subunit", "pathway_ids": ["R-GGA-429947", "R-RNO-429947", "R-MMU-429947", "R-DME-429947", "R-SPO-429947", "R-HSA-429947", "R-SCE-429947"], "pathways": ["R-GGA-429947:r:Deadenylation of mRNA", "R-RNO-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-DME-429947:r:Deadenylation of mRNA", "R-SPO-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-SCE-429947:r:Deadenylation of mRNA"], "type": "Family"}, "IPR050786": {"description": "EFG1 rRNA-processing", "go_ids": [], "go_terms": [], "name": "EFG1_rRNA-proc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050787": {"description": "Natriuretic Peptide Hormone", "go_ids": [], "go_terms": [], "name": "Natriuretic_peptide", "pathway_ids": ["R-HSA-5578768", "R-HSA-2032785", "R-MMU-5578768", "R-BTA-5578768", "R-CFA-5578768", "R-HSA-977225", "R-RNO-5578768"], "pathways": ["R-HSA-5578768:r:Physiological factors", "R-HSA-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-MMU-5578768:r:Physiological factors", "R-BTA-5578768:r:Physiological factors", "R-CFA-5578768:r:Physiological factors", "R-HSA-977225:r:Amyloid fiber formation", "R-RNO-5578768:r:Physiological factors"], "type": "Family"}, "IPR050788": {"description": "Yeast SRP1/TIP1 Cell Wall", "go_ids": [], "go_terms": [], "name": "Yeast_SRP1/TIP1_CWP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050789": {"description": "Diverse Enzymatic Activities", "go_ids": [], "go_terms": [], "name": "Diverse_Enzym_Activities", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050790": {"description": "ExbB/TolQ Biopolymer Transport", "go_ids": [], "go_terms": [], "name": "ExbB/TolQ_transport", "pathway_ids": ["R-HSA-9638334", "R-HSA-9927020", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9927020:r:Heme assimilation", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR050791": {"description": "Aldo/Keto Reductase", "go_ids": [], "go_terms": [], "name": "Aldo-Keto_reductase", "pathway_ids": ["PWY-5882", "PWY-5848", "PWY-7045", "PWY-5751", "PWY-7825", "PWY-7788", "PWY-5666", "PWY-8132", "PWY-8426", "PWY-5392", "PWY-6627", "PWY-6946", "PWY-7300", "PWY-6392", "PWY-6945", "PWY-6302", "PWY-8238", "PWY-7948", "PWY-7689", "PWY-8029", "PWY-7321", "PWY-7340", "PWY-7385", "PWY-7440", "PWY-7726", "PWY-5972", "PWY-7692", "PWY-1186", "PWY-8370", "PWY-7489", "PWY-7615", "PWY-7757", "PWY-7337", "PWY-6883", "PWY-7694", "PWY-7693", "PWY-6672", "PWY-7568", "PWY-3162", "PWY-5316", "PWY-5818", 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[], "name": "ComplexI_51kDa_subunit", "pathway_ids": ["R-DDI-9837999", "R-HSA-611105", "R-MMU-9837999", "R-SPO-9837999", "R-HSA-6799198", "R-MMU-6799198", "R-MMU-611105", "R-HSA-9837999", "R-DDI-6799198"], "pathways": ["R-DDI-9837999:r:Mitochondrial protein degradation", "R-HSA-611105:r:Respiratory electron transport", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-MMU-611105:r:Respiratory electron transport", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DDI-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR050838": {"description": "2-dehydropantoate 2-reductase-like", "go_ids": [], "go_terms": [], "name": "PANE-like", "pathway_ids": ["PWY-6654"], "pathways": ["PWY-6654:t:phosphopantothenate biosynthesis III (archaea)"], "type": "Family"}, "IPR050839": {"description": "Rho-associated Serine/Threonine Kinase", "go_ids": [], 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"R-CEL-9013149", "R-RNO-416482", "R-HSA-9013148", "R-RNO-3928662", "R-DME-9013406", "R-CEL-9013406", "R-HSA-5578775", "R-RNO-9013106", "R-MMU-111465", "R-RNO-5627117", "R-HSA-9679191", "R-CEL-416572", "R-DME-9013422", "R-DME-9013418", "R-BTA-9013422", "R-RNO-5625900", "R-HSA-3928663", "R-CEL-4420097", "R-MMU-9013026", "R-MMU-416482", "R-MMU-3928662", "R-HSA-111465", "R-HSA-9013406", "R-MMU-9013149", "R-DDI-2028269", "R-HSA-5627117"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-8980692:r:RHOA GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-6798695:r:Neutrophil degranulation", "R-DME-451806:r:Phosphorylation-independent inhibition of YKI", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-DME-390178:r:DS ligand not bound to FT receptor", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-CEL-9013407:r:RHOH GTPase cycle", "R-DME-390150:r:DS ligand bound to FT receptor", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-BTA-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-MMU-5625900:r:RHO GTPases activate CIT", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-5578775:r:Ion homeostasis", "R-CEL-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-390098:r:Phosphorylation-dependent inhibition of YKI", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-DME-390089:r:Formation of the Hippo kinase cassette", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-5625900:r:RHO GTPases activate CIT", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DME-2028269:r:Signaling by Hippo", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DME-9013406:r:RHOQ GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-CEL-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-DME-9013418:r:RHOBTB2 GTPase cycle", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-5625900:r:RHO GTPases activate CIT", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DDI-2028269:r:Signaling by Hippo", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Family"}, "IPR050840": {"description": "Adaptor Complexes Large Subunit", "go_ids": [], "go_terms": [], "name": "Adaptor_Complx_Large_Subunit", "pathway_ids": ["R-HSA-6798695", "R-RNO-5140745", "R-MMU-8856828", "R-SPO-437239", "R-SCE-8856828", "R-HSA-8856828", "R-MMU-5099900", "R-HSA-9918485", "R-BTA-6798695", "R-RNO-8964038", "R-DDI-8856825", "R-DME-5099900", "R-SPO-8856825", "R-RNO-177504", "R-DDI-8856828", "R-DME-3928665", "R-HSA-5140745", "R-DME-8964038", "R-DME-177504", "R-DDI-8964038", "R-RNO-8866427", "R-DDI-6798695", "R-DME-437239", "R-BTA-5099900", "R-HSA-432720", "R-DME-5140745", "R-HSA-437239", "R-MMU-5140745", "R-BTA-177504", "R-HSA-164940", "R-MMU-8866427", "R-SPO-8866427", "R-SCE-8856825", "R-MMU-6798695", "R-SCE-8866427", "R-RNO-6798695", "R-SPO-6798695", "R-HSA-2132295", "R-DME-416993", "R-MMU-8856825", "R-MMU-432722", "R-SCE-6798695", "R-BTA-416993", "R-DME-8866427", "R-DDI-437239", "R-SPO-8964038", "R-SCE-432720", "R-DDI-8866427", "R-MMU-8964038", "R-MMU-2132295", "R-DME-8856828", "R-BTA-437239", "R-RNO-8856828", "R-BTA-8866427", "R-MMU-432720", "R-RNO-5099900", "R-HSA-432722", "R-SCE-8964038", "R-SPO-432720", "R-BTA-2132295", "R-MMU-416993", "R-BTA-8856828", "R-DME-8856825", "R-HSA-416993", "R-MMU-437239", "R-RNO-2132295", "R-RNO-8856825", "R-RNO-437239", "R-DME-6798695", "R-DDI-432720", "R-HSA-167590", "R-HSA-5099900", "R-HSA-9679191", "R-SPO-8856828", "R-HSA-177504", "R-HSA-8866427", "R-BTA-8856825", "R-BTA-8964038", "R-HSA-8856825", "R-HSA-3928665", "R-SCE-437239", "R-MMU-177504", "R-BTA-5140745", "R-HSA-8964038", "R-RNO-416993", "R-HSA-182218"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-SPO-437239:r:Recycling pathway of L1", "R-SCE-8856828:r:Clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-8964038:r:LDL clearance", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-5099900:r:WNT5A-dependent internalization of FZD4", "R-SPO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-177504:r:Retrograde neurotrophin signalling", "R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-DME-8964038:r:LDL clearance", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-DDI-8964038:r:LDL clearance", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DME-437239:r:Recycling pathway of L1", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-437239:r:Recycling pathway of L1", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-SCE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-RNO-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-6798695:r:Neutrophil degranulation", "R-BTA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-DDI-437239:r:Recycling pathway of L1", "R-SPO-8964038:r:LDL clearance", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-MMU-8964038:r:LDL clearance", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-BTA-437239:r:Recycling pathway of L1", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SCE-8964038:r:LDL clearance", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-437239:r:Recycling pathway of L1", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-167590:r:Nef Mediated CD4 Down-regulation", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-8964038:r:LDL clearance", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-182218:r:Nef Mediated CD8 Down-regulation"], "type": "Family"}, "IPR050843": {"description": "Glycosyl Hydrolase Family 38", "go_ids": [], "go_terms": [], "name": "Glycosyl_Hydrlase_38", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-MMU-8853383", "R-BTA-8853383", "R-HSA-6811438", "R-DME-975578", "R-HSA-975578", "R-HSA-8853383", "R-HSA-9694548", "R-MMU-6798695", "R-RNO-975578", "R-BTA-6798695", "R-MMU-975578", "R-DDI-8853383"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-BTA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-6811438:r:Intra-Golgi traffic", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-9694548:r:Maturation of spike protein", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DDI-8853383:r:Lysosomal oligosaccharide catabolism"], "type": "Family"}, "IPR050844": {"description": "Coatomer complex subunit", "go_ids": [], "go_terms": [], "name": "Coatomer_complex_subunit", "pathway_ids": ["R-SPO-6807878", "R-GGA-380284", "R-DRE-1169091", "R-XTR-2467813", "R-DRE-8951664", "R-GGA-2565942", "R-XTR-380270", "R-MMU-6807878", "R-DRE-2467813", "R-DDI-6811434", "R-DRE-141444", "R-GGA-2500257", "R-DRE-983168", "R-XTR-141444", "R-BTA-6807878", "R-XTR-5620912", "R-HSA-6811434", "R-GGA-9648025", "R-BTA-6811434", "R-DRE-5676590", "R-GGA-5663220", "R-XTR-69601", "R-DRE-5663220", "R-GGA-2467813", "R-DME-6807878", "R-GGA-380259", "R-MMU-6811434", "R-XTR-9648025", "R-GGA-6811436", "R-RNO-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-GGA-380270", "R-RNO-6807878", "R-DRE-2500257", "R-DRE-69601", "R-HSA-6807878", "R-CEL-6807878", "R-XTR-5663220", "R-XTR-380284", "R-DRE-380320", "R-GGA-380320", "R-XTR-68877", "R-XTR-8951664", "R-GGA-5620912", "R-XTR-380259", "R-XTR-380320", "R-GGA-141444", "R-GGA-8854518", "R-DME-6811434", "R-DRE-5684264", "R-XTR-983168", "R-DDI-6807878", "R-DRE-2565942", "R-SPO-6811434", "R-XTR-2565942", "R-DRE-5607761", "R-XTR-8854518", "R-XTR-2500257", "R-CEL-6811434", "R-DRE-6811436"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-GGA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-DRE-8951664:r:Neddylation", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DDI-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-BTA-6807878:r:COPI-mediated anterograde transport", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-BTA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-XTR-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-GGA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-68877:r:Mitotic Prometaphase", "R-XTR-8951664:r:Neddylation", "R-GGA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-GGA-8854518:r:AURKA Activation by TPX2", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic"], "type": "Family"}, "IPR050845": {"description": "Copper-binding electron transfer protein", "go_ids": [], "go_terms": [], "name": "Cu-binding_ET", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050846": {"description": "TLC domain-containing", "go_ids": [], "go_terms": [], "name": "TLCD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050847": {"description": "Small acid-soluble spore DNA-binding", "go_ids": [], "go_terms": [], "name": "SASP_DNA-binding", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050848": {"description": "Homeobox domain-containing transcription factors", "go_ids": [], "go_terms": [], "name": "Homeobox_TF", "pathway_ids": ["R-HSA-8853884", "R-DME-8853884", "R-HSA-2559582"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-DME-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)"], "type": "Family"}, "IPR050849": {"description": "HAD-like hydrolase superfamily phosphatase", "go_ids": [], "go_terms": [], "name": "HAD-like_hydrolase_phosphatase", "pathway_ids": ["PWY-4361"], "pathways": ["PWY-4361:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"], "type": "Family"}, "IPR050850": {"description": "Peptidase S1 family, Elastase subfamily", "go_ids": [], "go_terms": [], "name": "Peptidase_S1_Elastase_sf", "pathway_ids": ["R-HSA-1474228", "R-HSA-6798695", "R-HSA-449836", "R-RNO-6809371", "R-MMU-977606", "R-HSA-6809371", "R-MMU-1592389", "R-HSA-5620971", "R-HSA-9925561", "R-HSA-1592389", "R-HSA-140875", "R-MMU-140875", "R-MMU-6809371", "R-HSA-977606", "R-SSC-6809371", "R-HSA-6803157", "R-HSA-9911233", "R-MMU-6798695", "R-MMU-5620971", "R-MMU-6803157", "R-HSA-1442490", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-6809371:r:Formation of the cornified envelope", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-6809371:r:Formation of the cornified envelope", "R-MMU-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-5620971:r:Pyroptosis", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-HSA-1592389:r:Activation of Matrix Metalloproteinases", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-977606:r:Regulation of Complement cascade", "R-SSC-6809371:r:Formation of the cornified envelope", "R-HSA-6803157:r:Antimicrobial peptides", "R-HSA-9911233:r:Expression of NOTCH2NL genes", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5620971:r:Pyroptosis", "R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Family"}, "IPR050851": {"description": "mRNA Cap 2'-O-Ribose Methyltransferase", "go_ids": [], "go_terms": [], "name": "mRNA_Cap_2O-Ribose_MeTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050852": {"description": "Queuine tRNA-ribosyltransferase", "go_ids": [], "go_terms": [], "name": "Queuine_tRNA-ribosyltrfase", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR050853": {"description": "WD repeat-containing DNA damage-binding protein", "go_ids": [], "go_terms": [], "name": "WD_repeat_DNA-damage-binding", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050854": {"description": "Lysosomal Cobalamin Transport Escort Protein LMBD1", "go_ids": [], "go_terms": [], "name": "LMBD1_LysCbl_Transport", "pathway_ids": ["R-XTR-9758890", "R-XTR-9758881", "R-DRE-9758881", "R-GGA-9758881", "R-DDI-9758881", "R-MMU-9758890", "R-GGA-9758890", "R-DRE-9758890", "R-HSA-9758881", "R-MMU-9758881", "R-HSA-9758890", "R-DDI-9758890", "R-HSA-5683329"], "pathways": ["R-XTR-9758890:r:Transport of RCbl within the body", "R-XTR-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DRE-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-GGA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-DDI-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-MMU-9758890:r:Transport of RCbl within the body", "R-GGA-9758890:r:Transport of RCbl within the body", "R-DRE-9758890:r:Transport of RCbl within the body", "R-HSA-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-MMU-9758881:r:Uptake of dietary cobalamins into enterocytes", "R-HSA-9758890:r:Transport of RCbl within the body", "R-DDI-9758890:r:Transport of RCbl within the body", "R-HSA-5683329:r:Defective ABCD4 causes MAHCJ"], "type": "Family"}, "IPR050855": {"description": "Metallo-beta-lactamase type 2-like", "go_ids": [], "go_terms": [], "name": "NDM-1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050856": {"description": "Biotin-dependent Carboxylase Complex", "go_ids": [], "go_terms": [], "name": "Biotin_carboxylase_complex", "pathway_ids": ["R-CEL-196780", "R-RNO-196780", "R-CEL-71032", "R-DDI-196780", "R-MMU-70895", "R-HSA-71032", "R-DDI-70895", "R-HSA-196780", "R-RNO-71032", "R-HSA-9909438", "R-MMU-71032", "R-HSA-70895", "R-HSA-3371599", "R-MMU-196780", "R-RNO-70895"], "pathways": ["R-CEL-196780:r:Biotin transport and metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-CEL-71032:r:Propionyl-CoA catabolism", "R-DDI-196780:r:Biotin transport and metabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-HSA-196780:r:Biotin transport and metabolism", "R-RNO-71032:r:Propionyl-CoA catabolism", "R-HSA-9909438:r:3-Methylcrotonyl-CoA carboxylase deficiency", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-196780:r:Biotin transport and metabolism", "R-RNO-70895:r:Branched-chain amino acid catabolism"], "type": "Family"}, "IPR050857": {"description": "D-isomer specific 2-hydroxyacid dehydrogenases", "go_ids": [], "go_terms": [], "name": "D-2-hydroxyacid_DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050858": {"description": "Malonyl CoA-ACP Transacylase/Polyketide Synthase FabD", "go_ids": [], "go_terms": [], "name": "Mal-CoA-ACP_Trans/PKS_FabD", "pathway_ids": ["PWY-8049", "PWY-8012", "PWY-8438", "PWY-8047", "PWY-6799", "PWY-4381", "R-SPO-77289", "R-SCE-77289"], "pathways": ["PWY-8049:t:pederin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-4381:t:fatty acid biosynthesis initiation (type II)", "R-SPO-77289:r:Mitochondrial Fatty Acid Beta-Oxidation", "R-SCE-77289:r:Mitochondrial Fatty Acid Beta-Oxidation"], "type": "Family"}, "IPR050859": {"description": "Class-I pyridoxal-phosphate-dependent aminotransferase-like", "go_ids": ["GO:0008483"], "go_terms": ["GO:0008483:transaminase activity:F"], "name": "Class-I_PLP-dep_aminotransf", "pathway_ids": ["R-SCE-71064", "R-HSA-71240", "R-SPO-71240", "R-MMU-71064", "R-SCE-71240", "R-HSA-71064", "R-SPO-71064", "R-MMU-71240", "R-DDI-71240", "R-DDI-71064", "R-RNO-71240", "R-RNO-71064"], "pathways": ["R-SCE-71064:r:Lysine catabolism", "R-HSA-71240:r:Tryptophan catabolism", "R-SPO-71240:r:Tryptophan catabolism", "R-MMU-71064:r:Lysine catabolism", "R-SCE-71240:r:Tryptophan catabolism", "R-HSA-71064:r:Lysine catabolism", "R-SPO-71064:r:Lysine catabolism", "R-MMU-71240:r:Tryptophan catabolism", "R-DDI-71240:r:Tryptophan catabolism", "R-DDI-71064:r:Lysine catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-RNO-71064:r:Lysine catabolism"], "type": "Family"}, "IPR050860": {"description": "Fe(2+) Transporter FeoB GTPase", "go_ids": [], "go_terms": [], "name": "FeoB_GTPase", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR050861": {"description": "Dihydroxyacetone Kinase (DAK)", "go_ids": [], "go_terms": [], "name": "Dihydroxyacetone_Kinase", "pathway_ids": ["R-SCE-70350", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9692916", "R-SPO-70350", "R-HSA-70350", "R-RNO-70350", "R-DDI-70350", "R-MMU-70350"], "pathways": ["R-SCE-70350:r:Fructose catabolism", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-SPO-70350:r:Fructose catabolism", "R-HSA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-DDI-70350:r:Fructose catabolism", "R-MMU-70350:r:Fructose catabolism"], "type": "Family"}, "IPR050862": {"description": "Ribonucleoside diphosphate reductase class-2", "go_ids": [], "go_terms": [], "name": "RdRp_reductase_class-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050863": {"description": "Centromere and Transposable Element-Derived Protein", "go_ids": [], "go_terms": [], "name": "CenT-Element_Derived", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050864": {"description": "Bacterial PTS System Sugar Transport Components", "go_ids": [], "go_terms": [], "name": "Bacterial_PTS_Sugar_Transport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050865": {"description": "BEACH Domain-Containing", "go_ids": [], "go_terms": [], "name": "BEACH_Domain", "pathway_ids": ["R-DDI-6798695", "R-HSA-6798695", "R-DRE-6798695", "R-HSA-5626978", "R-HSA-2122947", "R-MMU-6798695", "R-MMU-5626978", "R-HSA-112314", "R-HSA-9609736", "R-HSA-163615"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-HSA-112314:r:Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-HSA-163615:r:PKA activation"], "type": "Family"}, "IPR050866": {"description": 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cargo-targeting to cilium", "R-RNO-2485179:r:Activation of the phototransduction cascade", "R-HSA-2485179:r:Activation of the phototransduction cascade", "R-HSA-381753:r:Olfactory Signaling Pathway", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-DME-2485179:r:Activation of the phototransduction cascade", "R-CFA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DME-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-MMU-2485179:r:Activation of the phototransduction cascade", "R-GGA-2485179:r:Activation of the phototransduction cascade", "R-CEL-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-CFA-2485179:r:Activation of the phototransduction cascade", "R-GGA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-RNO-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Family"}, "IPR050867": {"description": "[NiFe]/[NiFeSe] hydrogenase large subunit", "go_ids": [], "go_terms": [], "name": "NiFe/NiFeSe_hydrgnase_LSU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050868": {"description": "Engulfment and cell motility domain-containing protein", "go_ids": [], "go_terms": [], "name": "ELMO_domain-containing", "pathway_ids": ["R-HSA-164944", "R-DDI-8849471", "R-MMU-9013408", "R-HSA-9013408", "R-HSA-2029482", "R-MMU-4420097", "R-HSA-9664422", "R-MMU-8849471", "R-MMU-2029482", "R-HSA-8849471", "R-HSA-4420097"], "pathways": ["R-HSA-164944:r:Nef and signal transduction", "R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Family"}, "IPR050869": {"description": "Histone-lysine N-methyltransferase", "go_ids": [], "go_terms": [], "name": "H3K4_H4K5_MeTrfase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-MMU-6804760", "R-DRE-6804760", "R-MMU-3214841", "R-DRE-3214841", "R-HSA-3214841", "R-HSA-9733709", "R-RNO-6804760", "R-CEL-3214841", "R-HSA-6804760", "R-SPO-3214841", "R-BTA-3214841", "R-RNO-3214841", "R-BTA-6804760"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-DRE-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9733709:r:Cardiogenesis", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-SPO-3214841:r:PKMTs methylate histone lysines", "R-BTA-3214841:r:PKMTs methylate histone lysines", "R-RNO-3214841:r:PKMTs methylate histone lysines", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation"], "type": "Family"}, "IPR050870": {"description": "FAST kinase domain-containing", "go_ids": [], "go_terms": [], "name": "FAST_kinase", "pathway_ids": ["R-HSA-9837092", "R-HSA-9937008", "R-HSA-6793080"], "pathways": ["R-HSA-9837092:r:FASTK family proteins regulate processing and stability of mitochondrial RNAs", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Family"}, "IPR050871": {"description": "26S Proteasome and COP9 Signalosome Components", "go_ids": [], "go_terms": [], "name": "26S_Proteasome/COP9_Components", "pathway_ids": ["R-XTR-8941858", "R-RNO-69017", "R-XTR-5610785", "R-CEL-9762114", "R-HSA-5358346", "R-CEL-8951664", "R-DME-5689880", "R-SPO-350562", "R-HSA-6798695", "R-MMU-5632684", "R-RNO-9020702", "R-SPO-9907900", "R-BTA-5610785", "R-BTA-202424", "R-XTR-9766229", "R-CEL-6798695", "R-HSA-9932298", "R-MMU-2467813", "R-BTA-6798695", "R-XTR-8948751", "R-DDI-1236978", "R-HSA-6781823", "R-DDI-8951664", "R-MMU-8951664", "R-DME-8939902", "R-RNO-174154", "R-CEL-382556", "R-DRE-6798695", "R-XTR-5607761", "R-CEL-5689603", "R-MMU-9929356", "R-XTR-69601", "R-DME-4608870", "R-SCE-5668541", "R-XTR-5689880", "R-RNO-9929356", "R-HSA-69481", "R-DME-9762114", "R-BTA-174084", "R-XTR-69017", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DDI-6781823", "R-DRE-9907900", "R-XTR-6798695", "R-HSA-4641258", "R-DRE-5696394", "R-RNO-8939236", "R-SPO-5689603", "R-DME-1236978", "R-CEL-6781823", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-BTA-4641258", "R-CEL-69017", "R-HSA-4608870", "R-MMU-4641257", "R-XTR-174184", "R-MMU-6798695", "R-RNO-2467813", "R-DME-5607764", "R-DME-209406", "R-XTR-450408", "R-DME-2871837", "R-DME-8941858", "R-DRE-382556", "R-MMU-5610780", "R-SPO-6798695", "R-DME-9954709", "R-XTR-5632684", "R-DRE-9762114", "R-BTA-382556", "R-XTR-2467813", "R-CEL-8939902", "R-MMU-9755511", "R-XTR-9954709", "R-MMU-9954709", "R-DDI-75815", "R-HSA-2871837", "R-RNO-5689603", "R-RNO-5610780", "R-HSA-5362768", "R-DME-5689603", "R-DDI-9954709", "R-DME-216167", "R-MMU-5658442", "R-RNO-8852276", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DRE-68949", "R-BTA-5610780", "R-DDI-69017", "R-RNO-9907900", "R-BTA-8948751", "R-RNO-8856825", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-XTR-5358346", "R-DDI-349425", "R-RNO-5607764", "R-XTR-983168", "R-RNO-8941858", "R-RNO-1169091", "R-XTR-9755511", "R-HSA-69017", "R-BTA-9020702", "R-RNO-9766229", "R-XTR-1234176", "R-BTA-5607764", "R-DDI-450408", "R-CEL-350562", "R-MMU-1236978", "R-HSA-202424", "R-DRE-68867", "R-CEL-4641257", "R-DDI-174154", "R-RNO-2871837", "R-XTR-5689603", "R-RNO-6781823", "R-MMU-450408", "R-RNO-68949", "R-HSA-9020702", "R-RNO-8948751", "R-DRE-1169091", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-5689880", "R-BTA-1234176", "R-MMU-174154", "R-MMU-69017", "R-CEL-195253", "R-DME-5658442", "R-MMU-9020702", "R-RNO-5687128", "R-RNO-382556", "R-DRE-8939236", "R-XTR-349425", "R-XTR-8939902", "R-MMU-69481", "R-BTA-350562", "R-DDI-8856825", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-DRE-187577", "R-BTA-5607761", "R-HSA-5610783", "R-MMU-174084", "R-DRE-5668541", "R-DRE-174184", "R-BTA-68867", "R-HSA-1234176", "R-RNO-4641258", "R-HSA-9931269", "R-MMU-68867", "R-HSA-9929491", "R-DRE-69601", "R-DME-209461", "R-XTR-9929491", "R-XTR-75815", "R-RNO-5689880", "R-RNO-5696394", "R-DRE-9755511", "R-DRE-5689603", "R-DME-75815", "R-DRE-350562", "R-RNO-8951664", "R-HSA-5696394", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-MMU-5687128", "R-DRE-4608870", "R-RNO-5358346", "R-CEL-8856825", "R-DME-5358346", "R-RNO-6798695", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-DRE-349425", "R-DRE-8939902", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-RNO-69601", "R-CEL-9907900", "R-CEL-983168", "R-XTR-8939236", "R-MMU-8939236", "R-MMU-6781823", "R-RNO-4641257", "R-DME-9907900", "R-XTR-5610780", "R-DDI-5689603", "R-CEL-75815", "R-DDI-2467813", "R-DRE-75815", "R-RNO-349425", "R-BTA-174184", "R-MMU-9762114", "R-DRE-6781823", "R-MMU-195253", "R-MMU-202424", "R-BTA-8939236", "R-HSA-5610780", "R-MMU-382556", "R-BTA-5632684", "R-DRE-174154", "R-DDI-5687128", "R-DME-209360", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-DME-432626", "R-DME-9013422", "R-XTR-8852276", "R-XTR-8951664", "R-MMU-5607761", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-XTR-174084", "R-DRE-9932298", "R-MMU-8939902", "R-XTR-9932298", "R-DME-174178", "R-DRE-9013422", "R-XTR-382556", "R-RNO-195253", "R-HSA-8939236", "R-XTR-5676590", "R-DRE-8854050", "R-BTA-983168", "R-DDI-8854050", "R-HSA-9013422", "R-MMU-5607764", "R-DME-6781823", "R-DRE-5632684", "R-DME-8951664", "R-DRE-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-CEL-187577", "R-HSA-5676590", "R-DRE-1236978", "R-DRE-9954709", "R-DDI-5632684", "R-BTA-9929491", "R-MMU-9013422", "R-XTR-5687128", "R-HSA-4641257", "R-RNO-202424", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9929491", "R-XTR-350562", "R-RNO-5607761", "R-HSA-68867", "R-DME-174154", "R-MMU-9907900", "R-CEL-4641258", "R-XTR-1236978", "R-BTA-450408", "R-DDI-5658442", "R-HSA-8941858", "R-HSA-9755511", "R-RNO-9931269", "R-DRE-1234176", "R-CEL-9929491", "R-DME-9755511", "R-HSA-1169091", "R-HSA-5658442", "R-DRE-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-XTR-5668541", "R-XTR-9907900", "R-DDI-68949", "R-MMU-9931269", "R-RNO-174084", "R-HSA-8948751", "R-DME-5610785", "R-HSA-5689603", "R-RNO-983168", "R-DME-450408", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DME-1169091", "R-DDI-9755511", "R-MMU-8856825", "R-DME-382556", "R-HSA-349425", "R-BTA-8941858", "R-DME-5610780", "R-DME-4641258", "R-HSA-174184", "R-MMU-350562", "R-DME-195253", "R-MMU-69601", "R-DRE-9929491", "R-BTA-2467813", "R-MMU-5610785", "R-DRE-69481", "R-DRE-8852276", "R-HSA-9954709", "R-MMU-5358346", "R-XTR-4641257", "R-DME-5607761", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-RNO-1236978", "R-DME-68949", "R-DRE-8856825", "R-DRE-5687128", "R-DRE-5689880", "R-CEL-1236978", "R-DME-8856825", "R-RNO-4608870", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-DRE-174084", "R-DRE-450408", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-HSA-5687128", "R-XTR-174178", "R-DME-5632684", "R-DME-432395", "R-RNO-5658442", "R-XTR-195253", "R-RNO-5610785", "R-MMU-983168", "R-HSA-350562", "R-DDI-174178", "R-DME-68867", "R-XTR-1169091", "R-DRE-4641258", "R-XTR-69481", 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"R-MMU-5578775"], "pathways": ["R-RNO-390522:r:Striated Muscle Contraction", "R-CEL-5578775:r:Ion homeostasis", "R-CFA-390522:r:Striated Muscle Contraction", "R-DME-5578775:r:Ion homeostasis", "R-HSA-390522:r:Striated Muscle Contraction", "R-RNO-5578775:r:Ion homeostasis", "R-MMU-390522:r:Striated Muscle Contraction", "R-HSA-5578775:r:Ion homeostasis", "R-MMU-5578775:r:Ion homeostasis"], "type": "Family"}, "IPR050876": {"description": "IgLON domain-containing protein", "go_ids": [], "go_terms": [], "name": "IgLON_domain", "pathway_ids": ["R-GGA-163125", "R-MMU-163125", "R-BTA-163125", "R-RNO-163125", "R-HSA-163125"], "pathways": ["R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-BTA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-RNO-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", 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"R-MMU-111885", "R-HSA-418555", "R-HSA-6785807", "R-RNO-194002", "R-BTA-193048", "R-RNO-209952", "R-HSA-418594", "R-HSA-5579031", "R-MMU-211976", "R-BTA-418555", "R-RNO-375276", "R-RNO-211976", "R-MMU-418555", "R-HSA-9856649", "R-HSA-211976", "R-RNO-202040", "R-BTA-375276", "R-HSA-194002"], "pathways": ["R-HSA-375276:r:Peptide ligand-binding receptors", "R-BTA-211976:r:Endogenous sterols", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-RNO-193048:r:Androgen biosynthesis", "R-MMU-418594:r:G alpha (i) signalling events", "R-BTA-202040:r:G-protein activation", "R-MMU-209952:r:Peptide hormone biosynthesis", "R-RNO-418594:r:G alpha (i) signalling events", "R-BTA-209952:r:Peptide hormone biosynthesis", "R-MMU-202040:r:G-protein activation", "R-BTA-418594:r:G alpha (i) signalling events", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-202040:r:G-protein activation", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-HSA-193048:r:Androgen biosynthesis", "R-MMU-193048:r:Androgen biosynthesis", "R-HSA-209952:r:Peptide hormone biosynthesis", "R-HSA-111885:r:Opioid Signalling", "R-RNO-111885:r:Opioid Signalling", "R-BTA-194002:r:Glucocorticoid biosynthesis", "R-BTA-111885:r:Opioid Signalling", "R-MMU-111885:r:Opioid Signalling", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-194002:r:Glucocorticoid biosynthesis", "R-BTA-193048:r:Androgen biosynthesis", "R-RNO-209952:r:Peptide hormone biosynthesis", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-5579031:r:Defective ACTH causes obesity and POMCD", "R-MMU-211976:r:Endogenous sterols", "R-BTA-418555:r:G alpha (s) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-RNO-211976:r:Endogenous sterols", "R-MMU-418555:r:G alpha (s) signalling events", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-211976:r:Endogenous sterols", "R-RNO-202040:r:G-protein activation", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-HSA-194002:r:Glucocorticoid biosynthesis"], "type": "Family"}, "IPR050879": {"description": "Acyltransferase 3", "go_ids": [], "go_terms": [], "name": "Acyltransferase_3", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR050881": {"description": "LL-diaminopimelate aminotransferase", "go_ids": [], "go_terms": [], "name": "LL-DAP_aminotransferase", "pathway_ids": ["PWY-5097"], "pathways": ["PWY-5097:t:L-lysine biosynthesis VI"], "type": "Family"}, "IPR050882": {"description": "Prepilin leader peptidase/N-methyltransferase", "go_ids": [], "go_terms": [], "name": "Prepilin_peptidase/N-MTase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR050883": {"description": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase", "go_ids": [], "go_terms": [], "name": "PNGase", "pathway_ids": ["R-HSA-532668", "R-MMU-532668", "R-CEL-532668", "R-DME-532668", "R-DRE-532668", "R-RNO-532668"], "pathways": ["R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-CEL-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-RNO-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "type": "Family"}, "IPR050884": {"description": "Cyclic nucleotide phosphodiesterase class-III", "go_ids": [], "go_terms": [], "name": "CNP_phosphodiesterase-III", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050886": {"description": "RNA-binding_regulatory_proteins", "go_ids": [], "go_terms": [], "name": "RNA-binding_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050887": {"description": "Beta-mannosidase glycosyl hydrolases", "go_ids": [], "go_terms": [], "name": "Beta-mannosidase_GH2", "pathway_ids": ["R-HSA-6798695", "R-MMU-6798695", "R-RNO-8853383", "R-MMU-8853383", "R-HSA-8853383", "R-CEL-8853383", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-CEL-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR050889": {"description": "Dendritic Spine Regulation and Scaffold", "go_ids": [], "go_terms": [], "name": "Dendritic_Spine_Reg/Scaffold", "pathway_ids": ["R-MMU-8951664", "R-SCE-8948751", "R-RNO-9764725", "R-HSA-9764725", "R-RNO-9843970", "R-HSA-9843970", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-RNO-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR050890": {"description": "Phosphotransferase system EIIA component", "go_ids": [], "go_terms": [], "name": "PTS_EIIA_component", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050891": {"description": "TatD-type Metallo-dependent Hydrolase", "go_ids": [], "go_terms": [], "name": "TatD-type_Hydrolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050892": {"description": "ADP-ribose derivative metabolism enzymes", "go_ids": [], "go_terms": [], "name": "ADP-ribose_metab_enzymes", "pathway_ids": ["PWY-6689"], "pathways": ["PWY-6689:t:tRNA splicing I"], "type": "Family"}, "IPR050893": {"description": "Sugar Phosphotransferase System (PTS)", "go_ids": [], "go_terms": [], "name": "Sugar_PTS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050895": {"description": "XK-related phospholipid scramblase", "go_ids": [], "go_terms": [], "name": "XK-related_scramblase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050896": {"description": "Mitochondrial lipid metabolism GTPase", "go_ids": [], "go_terms": [], "name": "Mito_lipid_metab_GTPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050897": {"description": "SMAUG/VTS1 RNA-binding", "go_ids": [], "go_terms": [], "name": "SMAUG/VTS1_RNA-bind", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050899": {"description": "DDRGK domain-containing protein", "go_ids": [], "go_terms": [], "name": "DDRGK_domain-containing", "pathway_ids": ["R-DRE-8980692", "R-HSA-8980692", "R-MMU-8980692"], "pathways": ["R-DRE-8980692:r:RHOA GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Family"}, "IPR050900": {"description": "Transposase IS3/IS150/IS904", "go_ids": [], "go_terms": [], "name": "Transposase_IS3/IS150/IS904", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050901": {"description": "Binding-protein-dependent ABC transporter permease", "go_ids": [], "go_terms": [], "name": "BP-dep_ABC_trans_perm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050902": {"description": "ABC Transporter Solute-Binding", "go_ids": [], "go_terms": [], "name": "ABC_Transporter_SBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050903": {"description": "Bacterial Chemotaxis Protein Methyltransferase", "go_ids": [], "go_terms": [], "name": "Bact_Chemotaxis_MeTrfase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050905": {"description": "Plant disease resistance NBS-LRR", "go_ids": [], "go_terms": [], "name": "Plant_NBS-LRR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050906": {"description": "Notch signaling pathway", "go_ids": [], "go_terms": [], "name": "Notch_signaling", "pathway_ids": ["R-HSA-2979096", "R-HSA-9911233"], "pathways": ["R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9911233:r:Expression of NOTCH2NL genes"], "type": "Family"}, "IPR050907": {"description": "Serine/Arginine-Rich Splicing Factor", "go_ids": [], "go_terms": [], "name": "SRSF", "pathway_ids": ["R-MMU-8941326", "R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-CEL-72165", "R-MMU-9770562", "R-MMU-72163", "R-BTA-72163", "R-CEL-72203", "R-HSA-73856", "R-DME-72163", "R-DME-159236", "R-MMU-73856", "R-HSA-72187", "R-CEL-73856", "R-BTA-73856", "R-MMU-159236", "R-DME-9770562", "R-HSA-72163", "R-DME-72203", "R-MMU-72187", "R-DME-72165", "R-CEL-9770562", "R-HSA-8941326", "R-BTA-9770562", "R-BTA-159236", "R-DME-73856", "R-HSA-159236", "R-CEL-72163", "R-BTA-72203", "R-HSA-9918481", "R-CEL-159236"], "pathways": ["R-MMU-8941326:r:RUNX2 regulates bone development", "R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-CEL-72165:r:mRNA Splicing - Minor Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72187:r:mRNA 3'-end processing", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-9770562:r:mRNA Polyadenylation", "R-HSA-8941326:r:RUNX2 regulates bone development", "R-BTA-9770562:r:mRNA Polyadenylation", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CEL-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR050908": {"description": "DNA gyrase inhibitor-like", "go_ids": [], "go_terms": [], "name": "SmbC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050909": {"description": "Bacterial Autotransporter Virulence Factors", "go_ids": [], "go_terms": [], "name": "Bact_Autotransporter_VF", "pathway_ids": ["R-HSA-9760173", "R-HSA-9927020"], "pathways": ["R-HSA-9760173:r:Secretion of toxins", "R-HSA-9927020:r:Heme assimilation"], "type": "Family"}, "IPR050910": {"description": "JMJD6 family arginine demethylases/lysyl-hydroxylases", "go_ids": [], "go_terms": [], "name": "JMJD6_ArgDemeth/LysHydrox", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-RNO-9629569", "R-RNO-3214842", "R-MMU-9629569", "R-DRE-3214842", "R-MMU-3214842", "R-SPO-9629569", "R-DME-3214842", "R-HSA-3214842", "R-DRE-9629569", "R-CEL-9629569", "R-DME-9629569", "R-CEL-3214842", "R-HSA-9629569"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C 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"PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-RNO-9629569:r:Protein hydroxylation", "R-RNO-3214842:r:HDMs demethylate histones", "R-MMU-9629569:r:Protein hydroxylation", "R-DRE-3214842:r:HDMs demethylate histones", "R-MMU-3214842:r:HDMs demethylate histones", "R-SPO-9629569:r:Protein hydroxylation", "R-DME-3214842:r:HDMs demethylate histones", "R-HSA-3214842:r:HDMs demethylate histones", "R-DRE-9629569:r:Protein hydroxylation", "R-CEL-9629569:r:Protein hydroxylation", "R-DME-9629569:r:Protein hydroxylation", "R-CEL-3214842:r:HDMs demethylate histones", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Family"}, "IPR050911": {"description": "DRAM/TMEM150 Autophagy Modulator", "go_ids": [], "go_terms": [], "name": "DRAM/TMEM150_Autophagy_Mod", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050913": {"description": 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"R-MMU-8937144", "R-RNO-211981", "R-DME-1234158", "R-HSA-1368108", "R-MMU-211945", "R-MMU-1234158", "R-DME-432560", "R-MMU-211981", "R-DME-9768919", "R-DME-8937144", "R-DRE-211981", "R-HSA-9931509", "R-HSA-8937144", "R-RNO-8937144", "R-CEL-1234158", "R-DRE-8937144", "R-DME-432524", "R-RNO-9768919", "R-HSA-9931521", "R-HSA-9707616", "R-DME-432626", "R-RNO-211945", "R-HSA-9931510", "R-DME-432620", "R-HSA-9931512", "R-DME-432408", "R-DME-432395", "R-MMU-9768919", "R-MMU-211976", "R-RNO-211976", "R-RNO-1234158", "R-DME-211945", "R-DRE-211945", "R-CEL-8937144", "R-HSA-9931529", "R-CEL-9768919", "R-HSA-211976", "R-DME-432501", "R-HSA-9768919"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-211981:r:Xenobiotics", "R-DRE-9768919:r:NPAS4 regulates expression of target genes", "R-DRE-211976:r:Endogenous sterols", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-CEL-211945:r:Phase I - Functionalization of compounds", "R-HSA-1234158:r:Regulation of gene 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"R-CEL-8937144:r:Aryl hydrocarbon receptor signalling", "R-HSA-9931529:r:Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK", "R-CEL-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-211976:r:Endogenous sterols", "R-DME-432501:r:Transcription repression by PER and activation by PDP1", "R-HSA-9768919:r:NPAS4 regulates expression of target genes"], "type": "Family"}, "IPR050934": {"description": "Inter-alpha-trypsin inhibitor heavy chain", "go_ids": [], "go_terms": [], "name": "ITIH", "pathway_ids": ["R-HSA-114608", "R-BTA-114608", "R-SSC-381426", "R-SSC-8957275", "R-MMU-381426", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", 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"R-HSA-9673324:r:WNT5:FZD7-mediated leishmania damping", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-450341:r:Activation of the AP-1 family of transcription factors", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DME-209409:r:Formation of the nuclear AP-1 transcription factor 'scaffolding complex'", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-450341:r:Activation of the AP-1 family of transcription factors", "R-DME-209394:r:Transcriptional activtion and repression of REL-68 target genes", "R-HSA-9031628:r:NGF-stimulated transcription", "R-RNO-450341:r:Activation of the AP-1 family of transcription factors", "R-GGA-437986:r:Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-RNO-2871796:r:FCERI mediated MAPK activation"], "type": "Family"}, "IPR050948": {"description": "Antp homeobox transcription factor", "go_ids": [], "go_terms": [], "name": "Antp_homeobox_TF", "pathway_ids": ["R-DRE-9762293", "R-HSA-9762293", "R-MMU-9762293"], "pathways": ["R-DRE-9762293:r:Regulation of CDH11 gene transcription", "R-HSA-9762293:r:Regulation of CDH11 gene transcription", "R-MMU-9762293:r:Regulation of CDH11 gene transcription"], "type": "Family"}, "IPR050949": {"description": "GPCR Frizzled/Smoothened-like", "go_ids": [], "go_terms": [], "name": "GPCR_Fz/Smo-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050950": {"description": "HTH-type LysR transcriptional regulators", "go_ids": [], "go_terms": [], "name": "HTH-type_LysR_regulators", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050952": {"description": "Tripartite Motif and NHL Repeat Containing E3 Ligases", "go_ids": [], "go_terms": [], "name": "TRIM-NHL_E3_ligases", "pathway_ids": ["PWY-7511", "R-DME-983168", "R-HSA-3322077", "R-HSA-877300", "R-DME-6798695", "R-MMU-983168", "R-MMU-6798695", "R-HSA-3785653", "R-HSA-983168", "R-RNO-983168", "R-DRE-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-3322077:r:Glycogen synthesis", "R-HSA-877300:r:Interferon gamma signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-3785653:r:Myoclonic epilepsy of Lafora", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR050953": {"description": "N(4)/N(6)-adenine-specific DNA methyltransferase", "go_ids": [], "go_terms": [], "name": "N4_N6_ade-DNA_methylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050954": {"description": "Electron transfer iron-sulfur cluster-binding protein", "go_ids": [], "go_terms": [], "name": "ET_IronSulfur_Cluster-Binding", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050955": {"description": "Plant Biomass Hydrolyzing Esterase", "go_ids": [], "go_terms": [], "name": "Plant_Biomass_Hydrol_Est", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050956": {"description": "Two-component system histidine kinase", "go_ids": [], "go_terms": [], "name": "2C_system_His_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050957": {"description": "BMP Lipoprotein", "go_ids": [], "go_terms": [], "name": "BMP_lipoprotein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050958": {"description": "Cell Adhesion and Cytoskeletal Organization", "go_ids": [], "go_terms": [], "name": "Cell_Adh-Cytoskel_Orgn", "pathway_ids": ["R-CEL-428542", "R-CEL-216083", "R-CEL-375165", "R-MMU-163125", "R-CEL-2022928", "R-CEL-9913351", "R-CEL-210991", "R-CEL-445144", "R-CEL-3000178", "R-CEL-9749641", "R-CEL-2024096", "R-CEL-5673001", "R-RNO-163125", "R-HSA-163125", "R-CEL-1474228", "R-CEL-1971475", "R-CEL-433692", "R-CEL-3000171", "R-CEL-419037"], "pathways": ["R-CEL-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-CEL-216083:r:Integrin cell surface interactions", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-CEL-2022928:r:HS-GAG biosynthesis", 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"R-MMU-373756:r:SDK interactions", "R-CEL-376176:r:Signaling by ROBO receptors", "R-CEL-525793:r:Myogenesis"], "type": "Family"}, "IPR050965": {"description": "UPF0336/Enoyl-CoA hydratase-related", "go_ids": [], "go_terms": [], "name": "UPF0336/Enoyl-CoA_hydratase", "pathway_ids": ["R-HSA-75105"], "pathways": ["R-HSA-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Family"}, "IPR050966": {"description": "Glutamyl Endopeptidase", "go_ids": [], "go_terms": [], "name": "Glutamyl_endopeptidase", "pathway_ids": ["R-BTA-8957275", "R-RNO-381426", "R-HSA-8957275", "R-MMU-381426", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426", "R-BTA-381426"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR050967": {"description": "Thiamine Salvage Pathway TenA", "go_ids": [], "go_terms": [], "name": "Thiamine_Salvage_TenA", "pathway_ids": ["PWY-6899", "PWY-7356"], "pathways": ["PWY-6899:t:base-degraded thiamine salvage", "PWY-7356:t:thiamine diphosphate salvage IV (yeast)"], "type": "Family"}, "IPR050968": {"description": "Cytochrome c oxidase bacterial subunit 4", "go_ids": [], "go_terms": [], "name": "Cytochrome_c_oxidase_bac_sub4", "pathway_ids": ["PWY-5787", "PWY-5780", "PWY-5399", "PWY-7079", "PWY-5476", "PWY-5439", "PWY-5404"], "pathways": ["PWY-5787:t:oligomeric urushiol biosynthesis", "PWY-5780:t:hypericin biosynthesis", "PWY-5399:t:betacyanin biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-5476:t:cornusiin E biosynthesis", "PWY-5439:t:betacyanin biosynthesis (via dopamine)", "PWY-5404:t:betaxanthin biosynthesis (via dopaxanthin)"], "type": "Family"}, "IPR050969": {"description": "Developmental Signaling Modulators", "go_ids": [], "go_terms": [], "name": "Dev_Signal_Modulators", "pathway_ids": ["R-DDI-1474228", "R-HSA-3772470", "R-HSA-201681", "R-DDI-1566977", "R-DDI-3000178", "R-DDI-2129379", "R-DDI-114608"], "pathways": ["R-DDI-1474228:r:Degradation of the extracellular matrix", "R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-DDI-1566977:r:Fibronectin matrix formation", "R-DDI-3000178:r:ECM proteoglycans", "R-DDI-2129379:r:Molecules associated with elastic fibres", "R-DDI-114608:r:Platelet degranulation"], "type": "Family"}, "IPR050970": {"description": "Voltage-gated chloride channel", "go_ids": [], "go_terms": [], "name": "Cl_channel_volt-gated", "pathway_ids": ["R-CEL-2672351", "R-HSA-2672351", "R-CFA-2672351", "R-RNO-2672351", "R-DDI-2672351", "R-MMU-2672351", "R-DME-2672351"], "pathways": ["R-CEL-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels", "R-CFA-2672351:r:Stimuli-sensing channels", "R-RNO-2672351:r:Stimuli-sensing channels", "R-DDI-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-DME-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR050971": {"description": "Cadherin domain-containing protein", "go_ids": [], "go_terms": [], "name": "Cadherin-domain_protein", "pathway_ids": ["R-HSA-6798695", "R-SSC-9696270", "R-SSC-6798695", "R-SSC-9696264", "R-HSA-6809371", "R-CEL-6798695", "R-MMU-9013408", "R-MMU-9013404", "R-HSA-351906", "R-HSA-9013423", "R-DRE-9696264", "R-HSA-9662360", "R-DRE-6798695", "R-RNO-6805567", "R-HSA-9013408", "R-DRE-9696270", "R-HSA-6805567", "R-CFA-6809371", "R-CEL-9013423", "R-RNO-6809371", "R-HSA-9696270", "R-CFA-351906", "R-DRE-6805567", "R-HSA-9662361", "R-DRE-6809371", "R-SSC-351906", "R-CFA-6805567", "R-MMU-351906", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-MMU-6809371", "R-SSC-6805567", "R-SSC-6809371", "R-DRE-351906", "R-MMU-6798695", "R-MMU-9696264", "R-CEL-6809371", "R-MMU-9696270", "R-MMU-6805567"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-9696270:r:RND2 GTPase cycle", "R-SSC-6798695:r:Neutrophil degranulation", "R-SSC-9696264:r:RND3 GTPase cycle", "R-HSA-6809371:r:Formation of the cornified envelope", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DRE-9696264:r:RND3 GTPase cycle", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6805567:r:Keratinization", "R-HSA-9013408:r:RHOG GTPase cycle", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-6805567:r:Keratinization", "R-CFA-6809371:r:Formation of the cornified envelope", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-RNO-6809371:r:Formation of the cornified envelope", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CFA-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DRE-6805567:r:Keratinization", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-DRE-6809371:r:Formation of the cornified envelope", "R-SSC-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-CFA-6805567:r:Keratinization", "R-MMU-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-6809371:r:Formation of the cornified envelope", "R-SSC-6805567:r:Keratinization", "R-SSC-6809371:r:Formation of the cornified envelope", "R-DRE-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-CEL-6809371:r:Formation of the cornified envelope", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-6805567:r:Keratinization"], "type": "Family"}, "IPR050972": {"description": "Serine-aspartate repeat-containing protein-like", "go_ids": [], "go_terms": [], "name": "SDr-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050973": {"description": "Histone-lysine N-methyltransferase, H3 Lys-9 specific", "go_ids": [], "go_terms": [], "name": "H3K9_Histone-Lys_N-MTase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", 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"PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-3214841", "R-DRE-3214841", "R-MMU-3214841", "R-DME-427359", "R-HSA-427359"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-427359:r:SIRT1 negatively regulates rRNA expression", "R-HSA-427359:r:SIRT1 negatively regulates rRNA expression"], "type": "Family"}, "IPR050974": {"description": "Plant Zinc finger CCCH domain-containing", "go_ids": [], "go_terms": [], "name": "Plant_ZF_CCCH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050975": {"description": "Sleep homeostasis regulator", "go_ids": [], "go_terms": [], "name": "Sleep_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050976": {"description": "Snake venom C-type lectin-like", "go_ids": [], "go_terms": [], "name": "Snaclec", "pathway_ids": ["R-MMU-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR050977": {"description": "Fungal Meroterpenoid Biosynthesis Isomerase", "go_ids": [], "go_terms": [], "name": "Fungal_Meroterpenoid_Isomerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050978": {"description": "Y' element ATP-dependent helicase", "go_ids": [], "go_terms": [], "name": "Y'_ATP-dependent_helicase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050979": {"description": "Bacterial L,D-transpeptidase", "go_ids": [], "go_terms": [], "name": "LD-transpeptidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050980": {"description": "Two-component sensor histidine kinase", "go_ids": [], "go_terms": [], "name": "2C_sensor_his_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050982": {"description": "Auxin biosynthesis and cation transport", "go_ids": [], "go_terms": [], "name": "Auxin_biosynth/cation_transpt", "pathway_ids": ["PWY-581"], "pathways": ["PWY-581:t:indole-3-acetate biosynthesis II"], "type": "Family"}, "IPR050983": {"description": "Glutathione S-transferase Omega/HSP26", "go_ids": [], "go_terms": [], "name": "GST_Omega/HSP26", "pathway_ids": ["R-CEL-156581", "R-MMU-196836", "R-DME-156590", "R-DME-156581", "R-CEL-196836", "R-RNO-196836", "R-SSC-156581", "R-HSA-8950505", "R-HSA-156590", "R-MMU-156581", "R-MMU-156590", "R-RNO-156590", "R-CEL-156590", "R-SSC-156590", "R-HSA-196836", "R-RNO-156581", "R-HSA-156581", "R-DME-196836", "R-SSC-196836"], "pathways": ["R-CEL-156581:r:Methylation", "R-MMU-196836:r:Vitamin C (ascorbate) metabolism", "R-DME-156590:r:Glutathione conjugation", "R-DME-156581:r:Methylation", "R-CEL-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-196836:r:Vitamin C (ascorbate) metabolism", "R-SSC-156581:r:Methylation", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-156590:r:Glutathione conjugation", "R-MMU-156581:r:Methylation", "R-MMU-156590:r:Glutathione conjugation", "R-RNO-156590:r:Glutathione conjugation", "R-CEL-156590:r:Glutathione conjugation", "R-SSC-156590:r:Glutathione conjugation", "R-HSA-196836:r:Vitamin C (ascorbate) metabolism", "R-RNO-156581:r:Methylation", "R-HSA-156581:r:Methylation", "R-DME-196836:r:Vitamin C (ascorbate) metabolism", "R-SSC-196836:r:Vitamin C (ascorbate) metabolism"], "type": "Family"}, "IPR050984": {"description": "Gfo/Idh/MocA domain-containing protein", "go_ids": [], "go_terms": [], "name": "Gfo/Idh/MocA_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050985": {"description": "Alpha-glycosidase and related enzymes", "go_ids": [], "go_terms": [], "name": "Alpha-glycosidase_related", "pathway_ids": ["PWY-6527"], "pathways": ["PWY-6527:t:stachyose degradation"], "type": "Family"}, "IPR050987": {"description": "ABC-transporter-regulating transcription factor-like", "go_ids": ["GO:0003700"], "go_terms": ["GO:0003700:DNA-binding transcription factor activity:F"], "name": "AtrR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050988": {"description": "Mannitol Dehydrogenase/Oxidoreductase", "go_ids": [], "go_terms": [], "name": "Mannitol_DH/Oxidoreductase", "pathway_ids": ["PWY-6531"], "pathways": ["PWY-6531:t:mannitol cycle"], "type": "Family"}, "IPR050989": {"description": "Rap1/Ran GTPase-activating", "go_ids": [], "go_terms": [], "name": "Rap1_Ran_GAP", "pathway_ids": ["R-MMU-8853659", "R-HSA-8853659", "R-HSA-392517", "R-MMU-392517", "R-HSA-6794361", "R-DDI-392517"], "pathways": ["R-MMU-8853659:r:RET signaling", "R-HSA-8853659:r:RET signaling", "R-HSA-392517:r:Rap1 signalling", "R-MMU-392517:r:Rap1 signalling", "R-HSA-6794361:r:Neurexins and neuroligins", "R-DDI-392517:r:Rap1 signalling"], "type": "Family"}, "IPR050990": {"description": "UPF0237/Glycine cleavage system regulator", "go_ids": [], "go_terms": [], "name": "UPF0237/GcvR_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050991": {"description": "Extracellular Matrix Regulatory Proteins", "go_ids": [], "go_terms": [], "name": "ECM_Regulatory_Proteins", "pathway_ids": ["R-HSA-8874081", "R-HSA-5674135", "R-HSA-9700645", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-RNO-1474228", "R-GGA-354194", "R-GGA-354192", "R-MMU-8957275", "R-MMU-3000170", "R-HSA-1650814", "R-RNO-9634597", "R-MMU-3000178", "R-HSA-9649948", "R-RNO-202733", "R-MMU-202733", "R-MMU-381426", "R-GGA-8957275", "R-HSA-8948216", "R-RNO-3000178", "R-HSA-6802955", "R-GGA-3000170", "R-HSA-381426", "R-MMU-1474228", "R-HSA-1474228", "R-HSA-6802948", "R-RNO-1566977", "R-GGA-216083", "R-GGA-2129379", "R-MMU-9634597", "R-HSA-3000171", "R-GGA-202733", "R-HSA-6785807", "R-GGA-5674135", "R-RNO-381426", "R-MMU-216083", "R-HSA-9860927", "R-HSA-372708", "R-GGA-9860927", "R-MMU-354192", "R-MMU-9860927", "R-HSA-9656223", "R-GGA-9634597", "R-MMU-114608", "R-HSA-9634597", "R-GGA-3000178", "R-MMU-5674135", "R-RNO-216083", "R-GGA-1474228", "R-MMU-8948216", "R-RNO-354194", "R-RNO-2129379", "R-RNO-114608", "R-RNO-9860927", "R-RNO-8874081", "R-MMU-372708", "R-HSA-114608", "R-HSA-9638630", "R-MMU-8874081", "R-RNO-354192", "R-HSA-6802946", "R-RNO-8957275", "R-RNO-5674135", "R-GGA-381426", "R-HSA-354192", "R-HSA-9925563", "R-HSA-2129379", "R-HSA-216083", "R-HSA-3000170", "R-MMU-1566977", "R-HSA-1566977", "R-HSA-354194", "R-MMU-354194", "R-GGA-114608", "R-GGA-1566977", "R-MMU-1650814", "R-HSA-8957275", "R-RNO-3000170", "R-HSA-9725370", "R-HSA-202733", "R-GGA-372708", "R-MMU-2129379"], "pathways": ["R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-GGA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-354192:r:Integrin signaling", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-MMU-3000170:r:Syndecan interactions", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-RNO-9634597:r:GPER1 signaling", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-GGA-8957275:r:Post-translational protein phosphorylation", "R-HSA-8948216:r:Collagen chain trimerization", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-GGA-3000170:r:Syndecan interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-RNO-1566977:r:Fibronectin matrix formation", "R-GGA-216083:r:Integrin cell surface interactions", "R-GGA-2129379:r:Molecules associated with elastic fibres", "R-MMU-9634597:r:GPER1 signaling", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-GGA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-GGA-5674135:r:MAP2K and MAPK activation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-GGA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-GGA-9634597:r:GPER1 signaling", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9634597:r:GPER1 signaling", "R-GGA-3000178:r:ECM proteoglycans", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-GGA-1474228:r:Degradation of the extracellular matrix", "R-MMU-8948216:r:Collagen chain trimerization", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-RNO-114608:r:Platelet degranulation", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-354192:r:Integrin signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-GGA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-354192:r:Integrin signaling", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-GGA-114608:r:Platelet degranulation", "R-GGA-1566977:r:Fibronectin matrix formation", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000170:r:Syndecan interactions", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-GGA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Family"}, "IPR050992": {"description": "Bacterial chemotaxis CheZ family phosphatases", "go_ids": [], "go_terms": [], "name": "CheZ_family_phosphatases", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR050993": {"description": "Isochorismatase domain-containing protein", "go_ids": [], "go_terms": [], "name": "Isochorismatase_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050994": {"description": "Arabidopsis Inactive Receptor-like Kinases", "go_ids": [], "go_terms": [], "name": "At_inactive_RLKs", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR050995": {"description": "WD repeat and F-box domain-containing protein", "go_ids": [], "go_terms": [], "name": "WD-F-box_domain-protein", "pathway_ids": ["R-HSA-9020702", "R-HSA-5610785", "R-HSA-3769402", "R-MMU-5607764", "R-HSA-8951664", "R-HSA-9932298", "R-HSA-5676590", "R-MMU-2565942", "R-MMU-69601", "R-DDI-8951664", "R-HSA-2565942", "R-MMU-8951664", "R-HSA-2871837", "R-HSA-5684264", "R-DDI-69601", "R-HSA-174113", "R-HSA-9762114", "R-HSA-5610783", "R-HSA-5607764", "R-MMU-202424", "R-HSA-195253", "R-MMU-5684264", "R-HSA-5610780", "R-HSA-5607761", "R-HSA-1170546", "R-MMU-1169091", "R-HSA-69601", "R-HSA-983168", "R-MMU-5607761", "R-MMU-5676590", "R-DDI-983168", "R-HSA-1169091", "R-HSA-9929356", "R-MMU-2871837", "R-MMU-983168", "R-HSA-180534", "R-HSA-202424"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-HSA-8951664:r:Neddylation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-8951664:r:Neddylation", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8951664:r:Neddylation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-1170546:r:Prolactin receptor signaling", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-202424:r:Downstream TCR signaling"], "type": "Family"}, "IPR050996": {"description": "Docking Protein Family (DOK)", "go_ids": [], "go_terms": [], "name": "Docking_Protein_DOK", "pathway_ids": ["R-HSA-8849469", "R-HSA-6798695", 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"R-MMU-5654693", "R-RNO-5654700", "R-MMU-5654689", "R-MMU-9696273", "R-MMU-9696270", "R-HSA-9725370", "R-HSA-9696273"], "pathways": ["R-HSA-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-5654720:r:PI-3K cascade:FGFR4", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-HSA-5654695:r:PI-3K cascade:FGFR2", "R-MMU-5654695:r:PI-3K cascade:FGFR2", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-8853659:r:RET signaling", "R-BTA-8853659:r:RET signaling", "R-MMU-5654732:r:Negative regulation of FGFR3 signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-RNO-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-170968:r:Frs2-mediated activation", "R-HSA-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-210993:r:Tie2 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"R-RNO-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-RNO-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-109704:r:PI3K Cascade", "R-MMU-8849469:r:PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-HSA-109704:r:PI3K Cascade", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-5654726:r:Negative regulation of FGFR1 signaling", "R-MMU-5654727:r:Negative regulation of FGFR2 signaling", "R-HSA-201556:r:Signaling by ALK", "R-HSA-170968:r:Frs2-mediated activation", "R-HSA-5654710:r:PI-3K cascade:FGFR3", "R-BTA-210993:r:Tie2 Signaling", "R-MMU-5654733:r:Negative regulation of FGFR4 signaling", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-RNO-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-5654689:r:PI-3K cascade:FGFR1", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Family"}, "IPR050997": {"description": "Membrane-associated proteins in eicosanoid and glutathione metabolism", "go_ids": [], "go_terms": [], "name": "MAPEG", "pathway_ids": ["R-HSA-2142700", "R-HSA-2142691", "R-HSA-9026766", "R-BTA-9026762", "R-RNO-2142700", "R-HSA-5423646", "R-RNO-2142688", "R-HSA-156590", "R-MMU-156590", "R-DDI-2142688", "R-MMU-5423646", "R-BTA-5423646", "R-MMU-2142688", "R-RNO-9026766", "R-DDI-2142691", "R-MMU-2142700", "R-DDI-2142700", "R-BTA-2142700", "R-RNO-9026762", "R-BTA-9026766", "R-DDI-9026762", "R-BTA-2142688", "R-HSA-2142688", "R-DDI-9026766", "R-MMU-9026762", "R-RNO-2142691", "R-MMU-9026766", "R-HSA-9026762", "R-MMU-2142691", "R-DDI-5423646", "R-BTA-2142691", "R-BTA-156590", "R-DDI-156590"], "pathways": ["R-HSA-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9026766:r:Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)", "R-BTA-9026762:r:Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "R-RNO-2142700:r:Biosynthesis of Lipoxins (LX)", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-RNO-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-HSA-156590:r:Glutathione conjugation", "R-MMU-156590:r:Glutathione conjugation", "R-DDI-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-BTA-5423646:r:Aflatoxin activation and detoxification", "R-MMU-2142688:r:Synthesis of 5-eicosatetraenoic acids", "R-RNO-9026766:r:Biosynthesis of protectin and resolvin conjugates in tissue 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"R-HSA-9026762:r:Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DDI-5423646:r:Aflatoxin activation and detoxification", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-BTA-156590:r:Glutathione conjugation", "R-DDI-156590:r:Glutathione conjugation"], "type": "Family"}, "IPR050998": {"description": "Forkhead box protein P", "go_ids": [], "go_terms": [], "name": "FOXP", "pathway_ids": ["R-HSA-452723", "R-MMU-8877330", "R-HSA-8877330", "R-HSA-8939256", "R-HSA-9764790"], "pathways": ["R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-MMU-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene 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"pathways": [], "type": "Family"}, "IPR051004": {"description": "Dendritic cell-specific ICAM-grabbing non-integrin domain-containing protein", "go_ids": [], "go_terms": [], "name": "DC-SIGN_domain-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051005": {"description": "Pentraxin domain-containing protein", "go_ids": [], "go_terms": [], "name": "Pentraxin_domain", "pathway_ids": ["R-SSC-173623", "R-HSA-173623", "R-RNO-173623", "R-MMU-173623", "R-HSA-977225"], "pathways": ["R-SSC-173623:r:Classical antibody-mediated complement activation", "R-HSA-173623:r:Classical antibody-mediated complement activation", "R-RNO-173623:r:Classical antibody-mediated complement activation", "R-MMU-173623:r:Classical antibody-mediated complement activation", "R-HSA-977225:r:Amyloid fiber formation"], "type": "Family"}, "IPR051006": {"description": "T cell receptor variable domain", "go_ids": [], "go_terms": [], "name": "TCR_variable_domain", "pathway_ids": ["R-HSA-198933", "R-HSA-202427", "R-HSA-389948", "R-HSA-202430", "R-HSA-202424", "R-HSA-202433"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-202433:r:Generation of second messenger molecules"], "type": "Family"}, "IPR051008": {"description": "Telomere Capping Maintenance Protein", "go_ids": [], "go_terms": [], "name": "Telomere_Capping_Maintenance", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051009": {"description": "Pheromone-regulated membrane protein 5-like", "go_ids": [], "go_terms": [], "name": "PRM5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051010": {"description": "Branched-chain amino acid transport protein", "go_ids": [], "go_terms": [], "name": "BCAA_transport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051011": {"description": "Metal-responsive transcriptional regulator", "go_ids": [], "go_terms": [], "name": "Metal_resp_trans_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051013": {"description": "N-acyl homoserine lactonase-like", "go_ids": [], "go_terms": [], "name": "AiiA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051014": {"description": "Cation Transport ATPase Type IB", "go_ids": [], "go_terms": [], "name": "Cation_Transport_ATPase_IB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051015": {"description": "DNA-binding transcriptional activator EvgA-like", "go_ids": [], "go_terms": [], "name": "EvgA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051016": {"description": "Diverse Substrate Acetyltransferase", "go_ids": [], "go_terms": [], "name": "Diverse_Substrate_AcTransf", "pathway_ids": ["R-MMU-351200", "R-SCE-351200", "R-GGA-351200", "R-SPO-351200", "R-BTA-351200", "R-HSA-351200", "R-CEL-351200"], "pathways": ["R-MMU-351200:r:Interconversion of polyamines", "R-SCE-351200:r:Interconversion of polyamines", "R-GGA-351200:r:Interconversion of polyamines", "R-SPO-351200:r:Interconversion of polyamines", "R-BTA-351200:r:Interconversion of polyamines", "R-HSA-351200:r:Interconversion of polyamines", "R-CEL-351200:r:Interconversion of polyamines"], "type": "Family"}, "IPR051017": {"description": "Aldolase class II Adducin subfamily", "go_ids": [], "go_terms": [], "name": "Aldolase-II_Adducin_sf", "pathway_ids": ["R-HSA-9013405", "R-MMU-9035034", "R-HSA-381038", "R-MMU-5223345", "R-RNO-9035034", "R-RNO-5223345", "R-CEL-9035034", "R-DME-5223345", "R-DME-9035034", "R-CEL-5223345", "R-HSA-9035034", "R-DME-264870", "R-MMU-264870", "R-RNO-264870", "R-HSA-264870", "R-HSA-5223345"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-RNO-9035034:r:RHOF GTPase cycle", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-CEL-9035034:r:RHOF GTPase cycle", "R-DME-5223345:r:Miscellaneous transport and binding events", "R-DME-9035034:r:RHOF GTPase cycle", "R-CEL-5223345:r:Miscellaneous transport and binding events", "R-HSA-9035034:r:RHOF GTPase cycle", "R-DME-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-MMU-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-RNO-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-264870:r:Caspase-mediated cleavage of cytoskeletal proteins", "R-HSA-5223345:r:Miscellaneous transport and binding events"], "type": "Family"}, "IPR051018": {"description": "Bacteriophage Glycosyl Hydrolase 24", "go_ids": [], "go_terms": [], "name": "Bacteriophage_GH24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051019": {"description": "VLCFA Elongation and Steroid Dehydrogenase", "go_ids": [], "go_terms": [], "name": "VLCFA-Steroid_DH", "pathway_ids": ["R-DRE-193048", "R-CEL-75876", "R-XTR-193048", "R-RNO-75876", "R-XTR-75876", "R-DRE-75876", "R-HSA-193048", "R-MMU-75876", "R-CEL-193048", "R-MMU-193048", "R-RNO-193048", "R-HSA-75876"], "pathways": ["R-DRE-193048:r:Androgen biosynthesis", "R-CEL-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-XTR-193048:r:Androgen biosynthesis", "R-RNO-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-XTR-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-DRE-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-HSA-193048:r:Androgen biosynthesis", "R-MMU-75876:r:Synthesis of very long-chain fatty acyl-CoAs", "R-CEL-193048:r:Androgen biosynthesis", "R-MMU-193048:r:Androgen biosynthesis", "R-RNO-193048:r:Androgen biosynthesis", "R-HSA-75876:r:Synthesis of very long-chain fatty acyl-CoAs"], "type": "Family"}, "IPR051020": {"description": "Aldehyde dehydrogenase-related metabolic enzymes", "go_ids": [], "go_terms": [], "name": "ALDH-related_metabolic_enz", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051021": {"description": "Mitochondrial serine/threonine phosphatase", "go_ids": [], "go_terms": [], "name": "Mito_Ser/Thr_phosphatase", "pathway_ids": ["R-DRE-9861718", "R-CEL-9861718", "R-HSA-8934903", "R-MMU-8934903", "R-DRE-8934903", "R-RNO-8934903", "R-CEL-8934903", "R-MMU-9861718", "R-DME-8934903", "R-RNO-9861718", "R-DME-9861718", "R-HSA-9861718"], "pathways": ["R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-CEL-9861718:r:Regulation of pyruvate metabolism", "R-HSA-8934903:r:Receptor Mediated Mitophagy", "R-MMU-8934903:r:Receptor Mediated Mitophagy", "R-DRE-8934903:r:Receptor Mediated Mitophagy", "R-RNO-8934903:r:Receptor Mediated Mitophagy", "R-CEL-8934903:r:Receptor Mediated Mitophagy", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DME-8934903:r:Receptor Mediated Mitophagy", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism"], "type": "Family"}, "IPR051023": {"description": "Protein Phosphatase 2A Regulatory Subunit A", "go_ids": [], "go_terms": [], "name": "PP2A_Regulatory_Subunit_A", "pathway_ids": ["R-SSC-5673000", "R-DME-69273", "R-HSA-9833482", "R-MMU-6811558", "R-CEL-195253", "R-SSC-69231", "R-CEL-5673000", "R-SPO-975957", "R-MMU-68877", "R-HSA-69231", "R-SSC-4641262", "R-MMU-380320", "R-SSC-9833482", "R-HSA-5673000", "R-RNO-6811558", "R-HSA-5467337", "R-SSC-2565942", "R-DME-1295596", "R-SSC-196299", "R-DDI-198753", "R-MMU-5620912", "R-CEL-69231", "R-SSC-1295596", "R-RNO-5673000", "R-HSA-5358752", "R-HSA-198753", "R-SSC-8854518", "R-HSA-163767", "R-HSA-202670", "R-SSC-389356", "R-DDI-113501", "R-MMU-196299", "R-MMU-380259", "R-SPO-6811558", "R-DME-209461", "R-SSC-432142", "R-CEL-2995383", "R-MMU-5673000", "R-HSA-141444", "R-SCE-202670", "R-MMU-380270", "R-RNO-5675221", "R-RNO-5663220", "R-RNO-180024", "R-RNO-202670", "R-HSA-9634600", "R-DME-5675221", "R-RNO-6804757", "R-HSA-389356", "R-DME-432620", "R-HSA-1295596", "R-SSC-975957", "R-MMU-4641262", "R-SCE-389513", "R-CEL-6811558", "R-MMU-69273", "R-MMU-5663220", "R-RNO-141444", "R-MMU-9860927", "R-MMU-5675221", "R-HSA-2467813", "R-DME-432553", "R-RNO-4641262", "R-DME-2995383", "R-SSC-202670", "R-MMU-380284", "R-HSA-196299", "R-RNO-9860927", "R-DME-209396", "R-HSA-68877", "R-HSA-4641262", "R-SSC-195253", "R-SSC-2995383", "R-SSC-9860927", "R-MMU-202670", "R-DME-389513", "R-SSC-9648025", "R-MMU-195253", "R-HSA-195253", "R-HSA-389513", "R-SSC-389513", "R-HSA-113501", "R-CEL-69273", "R-DDI-9833482", "R-DME-209360", "R-RNO-68877", "R-DDI-69231", "R-MMU-975957", "R-MMU-6804757", "R-MMU-113501", "R-HSA-2995383", "R-DME-432626", "R-HSA-380270", "R-DDI-5675221", "R-RNO-69273", "R-RNO-69231", "R-MMU-389513", "R-DME-9833482", "R-HSA-975957", "R-CEL-196299", "R-HSA-5663220", "R-RNO-9648025", "R-MMU-198753", "R-DME-975957", "R-RNO-195253", "R-SSC-180024", "R-SSC-5620912", "R-RNO-9833482", "R-DME-209155", "R-SSC-198753", "R-SSC-5663220", "R-SSC-5675221", "R-CEL-975957", "R-MMU-2467813", "R-DME-69231", "R-HSA-69273", "R-HSA-432142", "R-HSA-380284", "R-CEL-113501", "R-HSA-8854518", "R-MMU-1295596", "R-DME-113501", "R-MMU-2565942", "R-SSC-6811558", "R-MMU-432142", "R-SCE-6811558", "R-HSA-380320", "R-MMU-389356", "R-MMU-9833482", "R-HSA-5358747", "R-RNO-196299", "R-HSA-6804757", "R-DME-5673000", "R-DME-209413", "R-HSA-5358749", "R-MMU-141444", "R-SSC-380259", "R-CEL-9860927", "R-CEL-389513", "R-CEL-9833482", "R-HSA-9648025", "R-HSA-5467340", "R-HSA-6811558", "R-SSC-380284", "R-SPO-389513", "R-RNO-113501", "R-RNO-389513", "R-HSA-2465910", "R-MMU-8854518", "R-SSC-113501", "R-RNO-2467813", "R-HSA-9860927", "R-SPO-202670", "R-RNO-432142", "R-MMU-69231", "R-HSA-5358751", "R-SSC-380270", "R-SPO-198753", "R-RNO-2500257", "R-DDI-69273", "R-DDI-6811558", "R-HSA-5467348", "R-SSC-68877", "R-DME-9860927", "R-DME-195253", "R-HSA-2565942", "R-DME-6811558", "R-DME-209214", "R-SCE-975957", "R-MMU-180024", "R-HSA-5339716", "R-DDI-389513", "R-SPO-69273", "R-HSA-5620912", "R-MMU-9648025", "R-SSC-141444", "R-MMU-2995383", "R-HSA-180024", "R-SCE-69273", "R-DME-209190", "R-MMU-2500257", "R-SSC-69273", "R-HSA-2500257", "R-CEL-5675221", "R-DME-196299", "R-SSC-2467813", "R-RNO-389356", "R-DDI-202670", "R-DME-209440", "R-SSC-380320", "R-RNO-198753", "R-SSC-2500257", "R-HSA-380259", "R-SCE-198753", "R-HSA-5675221"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-DME-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-69231:r:Cyclin D associated events in G1", "R-CEL-5673000:r:RAF activation", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-69231:r:Cyclin D associated events in G1", "R-SSC-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-9833482:r:PKR-mediated signaling", "R-HSA-5673000:r:RAF activation", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-1295596:r:Spry regulation of FGF signaling", "R-SSC-196299:r:Beta-catenin phosphorylation cascade", "R-DDI-198753:r:ERK/MAPK targets", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-CEL-69231:r:Cyclin D associated events in G1", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-RNO-5673000:r:RAF activation", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-198753:r:ERK/MAPK targets", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-HSA-202670:r:ERKs are inactivated", "R-SSC-389356:r:Co-stimulation by CD28", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-SSC-432142:r:Platelet sensitization by LDL", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-5673000:r:RAF activation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SCE-202670:r:ERKs are inactivated", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-180024:r:DARPP-32 events", "R-RNO-202670:r:ERKs are inactivated", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-DME-5675221:r:Negative regulation of MAPK pathway", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-389356:r:Co-stimulation by CD28", "R-DME-432620:r:Dephosphorylation of PER", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-CEL-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SSC-202670:r:ERKs are inactivated", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-196299:r:Beta-catenin phosphorylation cascade", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-209396:r:Phosphorylation of ARM", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SSC-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SSC-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-202670:r:ERKs are inactivated", "R-DME-389513:r:Co-inhibition by CTLA4", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-389513:r:Co-inhibition by CTLA4", "R-SSC-389513:r:Co-inhibition by CTLA4", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-9833482:r:PKR-mediated signaling", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-RNO-68877:r:Mitotic Prometaphase", "R-DDI-69231:r:Cyclin D associated events in G1", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-432626:r:Circadian Clock pathway", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-198753:r:ERK/MAPK targets", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-180024:r:DARPP-32 events", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-SSC-198753:r:ERK/MAPK targets", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-432142:r:Platelet sensitization by LDL", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DME-5673000:r:RAF activation", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-SSC-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SPO-202670:r:ERKs are inactivated", "R-RNO-432142:r:Platelet sensitization by LDL", "R-MMU-69231:r:Cyclin D 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"R-MMU-180024:r:DARPP-32 events", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-180024:r:DARPP-32 events", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-209190:r:Phosphorylation of CI", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-RNO-389356:r:Co-stimulation by CD28", "R-DDI-202670:r:ERKs are inactivated", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-198753:r:ERK/MAPK targets", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-198753:r:ERK/MAPK targets", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR051024": {"description": "GlcNAc and Chitin Interaction and Degradation", "go_ids": [], "go_terms": [], "name": "GlcNAc_Chitin_IntDeg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051025": {"description": "Rho GTPase-activating", "go_ids": [], "go_terms": [], "name": "RhoGAP", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-MMU-8980692", "R-RNO-8980692", "R-SCE-6798695", "R-RNO-9013149", "R-MMU-9013148", "R-RNO-9013148", "R-SPO-9013148", "R-BTA-9013148", "R-SPO-8980692", "R-SCE-9013148", "R-HSA-9013149", "R-DRE-9013148", "R-HSA-8980692", "R-SCE-8980692", "R-SCE-9013149", "R-HSA-9013148", "R-DRE-9013149", "R-BTA-8980692", "R-MMU-6798695", "R-DRE-8980692", "R-MMU-9013149"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-SCE-6798695:r:Neutrophil degranulation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SCE-9013148:r:CDC42 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-SCE-8980692:r:RHOA GTPase cycle", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Family"}, "IPR051026": {"description": "Phosphatidylinositol/phosphatidylcholine transfer", "go_ids": [], "go_terms": [], "name": "PI/PC_transfer", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051028": {"description": "Mitochondrial Solute Carrier", "go_ids": [], "go_terms": [], "name": "Mito_Solute_Carrier", "pathway_ids": ["R-HSA-9856872", "R-RNO-8963693", "R-HSA-8963693", "R-HSA-442660", "R-CEL-9856872", "R-SCE-9856872", "R-RNO-442660", "R-DDI-9856872", "R-DDI-442660", "R-BTA-442660", "R-HSA-1268020", "R-MMU-442660", "R-DME-8963693", "R-DME-9856872", "R-MMU-8963693", "R-MMU-9856872", "R-DDI-8963693", "R-RNO-9856872", "R-SCE-442660", "R-CEL-8963693", "R-BTA-9856872", "R-SCE-8963693"], "pathways": ["R-HSA-9856872:r:Malate-aspartate shuttle", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-HSA-442660:r:SLC-mediated transport of neurotransmitters", "R-CEL-9856872:r:Malate-aspartate shuttle", "R-SCE-9856872:r:Malate-aspartate shuttle", "R-RNO-442660:r:SLC-mediated transport of neurotransmitters", "R-DDI-9856872:r:Malate-aspartate shuttle", "R-DDI-442660:r:SLC-mediated transport of neurotransmitters", "R-BTA-442660:r:SLC-mediated transport of neurotransmitters", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-442660:r:SLC-mediated transport of neurotransmitters", "R-DME-8963693:r:Aspartate and asparagine metabolism", "R-DME-9856872:r:Malate-aspartate shuttle", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-MMU-9856872:r:Malate-aspartate shuttle", "R-DDI-8963693:r:Aspartate and asparagine metabolism", "R-RNO-9856872:r:Malate-aspartate shuttle", "R-SCE-442660:r:SLC-mediated transport of neurotransmitters", "R-CEL-8963693:r:Aspartate and asparagine metabolism", "R-BTA-9856872:r:Malate-aspartate 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"R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-176412:r:Phosphorylation of the APC/C", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-68949:r:Orc1 removal from chromatin", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-BTA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-9020702:r:Interleukin-1 signaling", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-8951664:r:Neddylation", "R-SPO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-8951664:r:Neddylation", "R-BTA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-BTA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9708530:r:Regulation of BACH1 activity", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-BTA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-6782135:r:Dual incision in TC-NER", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-68949:r:Orc1 removal from chromatin", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-1170546:r:Prolactin receptor signaling", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-BTA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-68949:r:Orc1 removal from chromatin", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5632684:r:Hedgehog 'on' state", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin"], "type": "Family"}, "IPR051032": {"description": "AP2/ERF transcription factor, ERF subfamily", "go_ids": [], "go_terms": [], "name": "AP2/ERF_TF_ERF_subfamily", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051033": {"description": "SH3 domain-binding glutamic acid-rich protein", "go_ids": [], "go_terms": [], "name": "SH3BGR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051034": {"description": "Mitochondrial Enoyl-ACP Reductase", "go_ids": [], "go_terms": [], "name": "Mito_Enoyl-ACP_Reductase", "pathway_ids": ["PWY-8280", "R-MMU-77346", "R-RNO-77346", "R-SCE-77346", "R-DRE-77346", "R-SPO-77346", "R-DDI-77346", "R-CEL-77346", "R-HSA-77346", "R-DME-77346", "R-XTR-77346"], "pathways": ["PWY-8280:t:stearate biosynthesis IV", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SCE-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DRE-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SPO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DDI-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-DME-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-XTR-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "type": "Family"}, "IPR051035": {"description": "Mitochondrial inheritance protein 9", "go_ids": [], "go_terms": [], "name": "Mito_inheritance_9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051036": {"description": "Sialic acid-binding Ig-like lectin", "go_ids": [], "go_terms": [], "name": "SIGLEC", "pathway_ids": ["R-HSA-6798695", "R-HSA-193634", "R-MMU-198933", "R-RNO-210991", "R-MMU-210991", "R-HSA-2172127", "R-HSA-9918485", "R-HSA-198933", "R-HSA-9619665", "R-MMU-193634", "R-MMU-6798695", "R-RNO-193634", "R-HSA-210991", "R-MMU-2172127"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-RNO-210991:r:Basigin interactions", "R-MMU-210991:r:Basigin interactions", "R-HSA-2172127:r:DAP12 interactions", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-210991:r:Basigin interactions", "R-MMU-2172127:r:DAP12 interactions"], "type": "Family"}, "IPR051037": {"description": "RNA Polymerase II Transcription Factor IWS1", "go_ids": [], "go_terms": [], "name": "RNAPII_TF_IWS1", "pathway_ids": ["R-CEL-674695", "R-HSA-112382", "R-CEL-75955", "R-XTR-674695", "R-RNO-674695", "R-RNO-112382", "R-CEL-112382", "R-HSA-75955", "R-RNO-75955", "R-XTR-75955", "R-XTR-112382", "R-HSA-674695", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Family"}, "IPR051038": {"description": "RMT2/GAMT Methyltransferase", "go_ids": [], "go_terms": [], "name": "RMT2/GAMT_Mtase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-DRE-71288", "R-HSA-71288", "R-MMU-71288", "R-SCE-71288", "R-RNO-71288", "R-XTR-71288", "R-SPO-71288", "R-HSA-8986944", "R-BTA-71288"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-DRE-71288:r:Creatine metabolism", "R-HSA-71288:r:Creatine metabolism", "R-MMU-71288:r:Creatine metabolism", "R-SCE-71288:r:Creatine metabolism", "R-RNO-71288:r:Creatine metabolism", "R-XTR-71288:r:Creatine metabolism", "R-SPO-71288:r:Creatine metabolism", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-BTA-71288:r:Creatine metabolism"], "type": "Family"}, "IPR051040": {"description": "Cytochrome c oxidase-assembly factor COX23", "go_ids": [], "go_terms": [], "name": "COX23", "pathway_ids": ["R-HSA-1268020"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR051041": {"description": "FMRFamide-related neuropeptide", "go_ids": [], "go_terms": [], "name": "FMRFamide-related_np", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051042": {"description": "Mammalian Reproductive Hormone Insulin-like", "go_ids": [], "go_terms": [], "name": "Repro_Hormone_Insulin-like", "pathway_ids": ["R-MMU-444821", "R-HSA-418555", "R-HSA-444821", "R-RNO-444821", "R-MMU-418555"], "pathways": ["R-MMU-444821:r:Relaxin receptors", "R-HSA-418555:r:G alpha (s) signalling events", "R-HSA-444821:r:Relaxin receptors", "R-RNO-444821:r:Relaxin receptors", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Family"}, "IPR051043": {"description": "Sulfatase Modifying Factor and Kinase", "go_ids": [], "go_terms": [], "name": "Sulfatase_Mod_Factor_Kinase", "pathway_ids": ["R-MMU-9840310", "R-BTA-9840310", "R-HSA-9840310", "R-HSA-1663150", "R-BTA-1663150", "R-MMU-1663150"], "pathways": ["R-MMU-9840310:r:Glycosphingolipid catabolism", "R-BTA-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-1663150:r:The activation of arylsulfatases", "R-BTA-1663150:r:The activation of arylsulfatases", "R-MMU-1663150:r:The activation of arylsulfatases"], "type": "Family"}, "IPR051044": {"description": "Monoacylglycerol and Diacylglycerol Lipase", "go_ids": [], "go_terms": [], "name": "MAG_DAG_Lipase", "pathway_ids": ["R-SPO-1482883", "R-RNO-1482883", "R-MMU-1482883", "R-HSA-163560", "R-HSA-426048", "R-SPO-426048", "R-RNO-426048", "R-HSA-1482883", "R-MMU-426048", "R-HSA-9841922", "R-DDI-426048", "R-SCE-426048", "R-DDI-1482883", "R-SCE-1482883"], "pathways": ["R-SPO-1482883:r:Acyl chain remodeling of DAG and TAG", "R-RNO-1482883:r:Acyl chain remodeling of DAG and TAG", "R-MMU-1482883:r:Acyl chain remodeling of DAG and TAG", "R-HSA-163560:r:Triglyceride catabolism", "R-HSA-426048:r:Arachidonate production from DAG", "R-SPO-426048:r:Arachidonate production from DAG", "R-RNO-426048:r:Arachidonate production from DAG", "R-HSA-1482883:r:Acyl chain remodeling of DAG and TAG", "R-MMU-426048:r:Arachidonate production from DAG", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DDI-426048:r:Arachidonate production from DAG", "R-SCE-426048:r:Arachidonate production from DAG", "R-DDI-1482883:r:Acyl chain remodeling of DAG and TAG", "R-SCE-1482883:r:Acyl chain remodeling of DAG and TAG"], "type": "Family"}, "IPR051045": {"description": "TonB-dependent transporter energy transducer", "go_ids": [], "go_terms": [], "name": "TonB-dependent_transducer", "pathway_ids": ["R-HSA-9638334", "R-HSA-9927020", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9927020:r:Heme assimilation", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR051046": {"description": "MurCDEF Family: Cell Wall and Coenzyme F430 Synthesis", "go_ids": [], "go_terms": [], "name": "MurCDEF_CellWall_CoF430Synth", "pathway_ids": ["PWY-7953", "PWY-6387", "PWY-6386"], "pathways": ["PWY-7953:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)", "PWY-6387:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)", "PWY-6386:t:UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "type": "Family"}, "IPR051047": {"description": "Acyl-CoA Carboxylase Beta Subunit", "go_ids": [], "go_terms": [], "name": "AccD/PCCB", "pathway_ids": ["R-RNO-196780", "R-MMU-9837999", "R-HSA-71032", "R-HSA-196780", "R-RNO-71032", "R-HSA-9837999", "R-MMU-71032", "R-RNO-9837999", "R-HSA-3371599", "R-MMU-196780"], "pathways": ["R-RNO-196780:r:Biotin transport and metabolism", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-71032:r:Propionyl-CoA catabolism", "R-HSA-196780:r:Biotin transport and metabolism", "R-RNO-71032:r:Propionyl-CoA catabolism", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-71032:r:Propionyl-CoA catabolism", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-196780:r:Biotin transport and metabolism"], "type": "Family"}, "IPR051048": {"description": "Peptidase S8/S53 subtilisin kexin sedolisin", "go_ids": [], "go_terms": [], "name": "Peptidase_S8/S53_subtilisin", "pathway_ids": ["R-PFA-2173796"], "pathways": ["R-PFA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "type": "Family"}, "IPR051049": {"description": "Dienelactone hydrolase-like enzyme", "go_ids": [], "go_terms": [], "name": "Dienelactone_hydrolase-like", "pathway_ids": ["PWY-6084", "PWY-6093", "PWY-6087", "PWY-6094", "PWY-6089", "PWY-6193"], "pathways": ["PWY-6084:t:3,5-dichlorocatechol degradation", "PWY-6093:t:4,5-dichlorocatechol degradation", "PWY-6087:t:4-chlorocatechol degradation", "PWY-6094:t:3,4,6-trichlorocatechol degradation", "PWY-6089:t:3-chlorocatechol degradation I (ortho)", "PWY-6193:t:3-chlorocatechol degradation II (ortho)"], "type": "Family"}, "IPR051051": {"description": "E3 ubiquitin-protein ligase TRIM/RNF", "go_ids": [], "go_terms": [], "name": "E3_ubiq-ligase_TRIM/RNF", "pathway_ids": ["PWY-7511", "R-HSA-9833109", "R-MMU-9909505", "R-HSA-9705671", "R-HSA-168928", "R-HSA-9833482", "R-HSA-5689896", "R-HSA-9920588", "R-HSA-933542", "R-MMU-5656169", "R-HSA-936440", "R-HSA-1169408", "R-MMU-1169408", "R-HSA-9909505", "R-HSA-918233", "R-MMU-9833482", "R-HSA-933541", "R-HSA-933543", "R-HSA-877300", "R-HSA-9692916", "R-HSA-9833110", "R-HSA-5656169"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-MMU-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-877300:r:Interferon gamma signaling", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-5656169:r:Termination of translesion DNA synthesis"], "type": "Family"}, "IPR051052": {"description": "Diverse substrate methyltransferase", "go_ids": [], "go_terms": [], "name": "Diverse_substrate_MTase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate 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"IPR051071": {"description": "Leucine-rich repeat-containing bacterial E3 ubiquitin ligases", "go_ids": [], "go_terms": [], "name": "LRR-bact_E3_ubiq_ligases", "pathway_ids": ["PWY-7511", "R-MMU-193634", "R-HSA-193634", "R-HSA-9956593"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-9956593:r:Enterobacterial factors antagonize host defense"], "type": "Family"}, "IPR051072": {"description": "Voltage-dependent calcium channel gamma subunit", "go_ids": [], "go_terms": [], "name": "CACNG_subunit", "pathway_ids": ["R-RNO-5682910", "R-HSA-399719", "R-RNO-5576893", "R-RNO-112308", "R-BTA-5682910", "R-MMU-5576892", "R-HSA-9856532", "R-RNO-399719", "R-HSA-5576892", "R-HSA-5576893", "R-MMU-5576893", "R-MMU-5682910", "R-BTA-399719", "R-HSA-5682910", "R-HSA-112308", "R-MMU-112308", "R-MMU-399719", "R-RNO-5576892"], "pathways": ["R-RNO-5682910:r:LGI-ADAM interactions", "R-HSA-399719:r:Trafficking of AMPA receptors", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-BTA-5682910:r:LGI-ADAM interactions", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-RNO-399719:r:Trafficking of AMPA receptors", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-MMU-5682910:r:LGI-ADAM interactions", "R-BTA-399719:r:Trafficking of AMPA receptors", "R-HSA-5682910:r:LGI-ADAM interactions", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-399719:r:Trafficking of AMPA receptors", "R-RNO-5576892:r:Phase 0 - rapid depolarisation"], "type": "Family"}, "IPR051073": {"description": "ZNRF3/Arkadia E3 ubiquitin-protein ligases", "go_ids": [], "go_terms": [], "name": "ZNRF3_Arkadia_E3_ligases", "pathway_ids": ["PWY-7511", "R-MMU-4641263", "R-HSA-5689896", "R-HSA-5689880", "R-HSA-4641263", "R-DRE-4641263", "R-MMU-2173796", "R-HSA-983168", "R-MMU-5689896", "R-MMU-5689880", "R-XTR-4641263", "R-MMU-5696395", "R-XTR-983168", "R-HSA-5696395", "R-HSA-2173795", "R-MMU-983168", "R-HSA-5340588", "R-XTR-2173796", "R-HSA-2173796"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-DRE-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5340588:r:Signaling by RNF43 mutants", "R-XTR-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "type": "Family"}, "IPR051074": {"description": "Sorting Nexin", "go_ids": [], "go_terms": [], "name": "Sorting_Nexin", "pathway_ids": ["R-BTA-3238698", "R-MMU-5689880", "R-MMU-3238698", "R-HSA-5689880", "R-HSA-3238698", "R-SCE-3238698", "R-RNO-3238698", "R-SPO-3238698", "R-RNO-5689880"], "pathways": ["R-BTA-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking", "R-SCE-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-3238698:r:WNT ligand biogenesis and trafficking", "R-SPO-3238698:r:WNT ligand biogenesis and trafficking", "R-RNO-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR051075": {"description": "SCF complex subunit WD repeat-containing protein", "go_ids": [], "go_terms": [], "name": "SCF_subunit_WD-repeat", "pathway_ids": ["R-MMU-8951664", "R-HSA-983168", "R-HSA-390471", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR051076": {"description": "Golgi apparatus membrane protein TVP38/TMEM64", "go_ids": [], "go_terms": [], "name": "Golgi_membrane_TVP38/TMEM64", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051077": {"description": "Calcium-dependent Lectin", "go_ids": [], "go_terms": [], "name": "Ca-dependent_lectin", "pathway_ids": ["R-HSA-9705671", "R-HSA-9920588", "R-HSA-3000480", "R-HSA-166016", "R-RNO-166662", "R-HSA-168179", "R-BTA-3000480", "R-MMU-3000480", "R-SSC-5686938", "R-MMU-166662", "R-GGA-2132270", "R-BTA-391160", "R-GGA-2132263", "R-HSA-166663", "R-HSA-5686938", "R-MMU-5683826", "R-RNO-5686938", "R-DRE-3000480", "R-MMU-391160", "R-MMU-166016", "R-DRE-166662", "R-SSC-166016", "R-RNO-391160", "R-RNO-5683826", "R-MMU-5686938", "R-HSA-391160", "R-BTA-5686938", "R-BTA-166016", "R-HSA-5688890", "R-HSA-5683826", "R-SSC-391160", "R-HSA-9692916", "R-HSA-166662", "R-HSA-198933", "R-BTA-5683826", "R-RNO-166016", "R-SSC-5683826", "R-HSA-5688849", "R-BTA-166662"], "pathways": ["R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-166662:r:Lectin pathway of complement activation", "R-HSA-168179:r:Toll Like Receptor TLR1:TLR2 Cascade", "R-BTA-3000480:r:Scavenging by Class A Receptors", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-SSC-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-166662:r:Lectin pathway of complement activation", "R-GGA-2132270:r:Lectin-mediated initiation of complement cascade", "R-BTA-391160:r:Signal regulatory protein family interactions", "R-GGA-2132263:r:Creation of classical C3 convertase", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-5683826:r:Surfactant metabolism", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-DRE-3000480:r:Scavenging by Class A Receptors", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DRE-166662:r:Lectin pathway of complement activation", "R-SSC-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-BTA-5686938:r:Regulation of TLR by endogenous ligand", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-SSC-391160:r:Signal regulatory protein family interactions", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-166662:r:Lectin pathway of complement activation", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-BTA-5683826:r:Surfactant metabolism", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-SSC-5683826:r:Surfactant metabolism", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-BTA-166662:r:Lectin pathway of complement activation"], "type": "Family"}, "IPR051078": {"description": "SAGA-associated factor 11", "go_ids": [], "go_terms": [], "name": "SGF11", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Family"}, "IPR051079": {"description": "Sorting Nexin Autophagy-related", "go_ids": [], "go_terms": [], "name": "Sorting_Nexin_Autophagy", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051080": {"description": "Nematode receptor-like serpentine class alpha", "go_ids": [], "go_terms": [], "name": "Nematode_rcpt-like_serp_alpha", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051081": {"description": "HTH-type Metal-responsive Transcriptional Regulators", "go_ids": [], "go_terms": [], "name": "HTH_MetalResp_TranReg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051082": {"description": "Pentapeptide repeat and BTB/POZ domain-containing protein", "go_ids": [], "go_terms": [], "name": "Pentapeptide-BTB/POZ_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051083": {"description": "Group II Intron Splicing and Mobility/Defense", "go_ids": [], "go_terms": [], "name": "GrpII_Intron_Splice-Mob/Def", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051085": {"description": "Membrane-bound O-acyltransferase", "go_ids": [], "go_terms": [], "name": "MB_O-acyltransferase", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-DME-209471", "R-HSA-5658034", "R-DME-5358346", "R-MMU-5358346", "R-HSA-5358346"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-DME-209471:r:Formation and transport of the N-HH ligand", "R-HSA-5658034:r:HHAT G278V doesn't palmitoylate Hh-Np", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Family"}, "IPR051086": {"description": "Ribonuclease D-like", "go_ids": [], "go_terms": [], "name": "RNase_D-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051087": {"description": "Mitochondrial Acyl-CoA Synthetase Medium-Chain", "go_ids": [], "go_terms": [], "name": "Mitochondrial_ACSM", "pathway_ids": ["PWY-8182", "PWY-5140", "PWY-7948", "PWY-8181", "R-MMU-177135", "R-HSA-177162", "R-HSA-177128", "R-RNO-177135", "R-HSA-9749641", "R-MMU-177128", "R-RNO-9749641", "R-MMU-9749641", "R-RNO-177162", "R-RNO-177128", "R-HSA-177135", "R-HSA-77352", "R-MMU-177162"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-5140:t:cannabinoid biosynthesis", "PWY-7948:t:4-oxopentanoate degradation", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "R-MMU-177135:r:Conjugation of benzoate with glycine", "R-HSA-177162:r:Conjugation of phenylacetate with glutamine", "R-HSA-177128:r:Conjugation of salicylate with glycine", "R-RNO-177135:r:Conjugation of benzoate with glycine", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-177128:r:Conjugation of salicylate with glycine", "R-RNO-9749641:r:Aspirin ADME", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-177162:r:Conjugation of phenylacetate with glutamine", "R-RNO-177128:r:Conjugation of salicylate with glycine", "R-HSA-177135:r:Conjugation of benzoate with glycine", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-177162:r:Conjugation of phenylacetate with glutamine"], "type": "Family"}, "IPR051088": {"description": "Bacterial PTS System Sugar-Specific EIIC/EIIB", "go_ids": [], "go_terms": [], "name": "PTS_Sugar-EIIC/EIIB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051090": {"description": "Inositol Monophosphatase Superfamily", "go_ids": [], "go_terms": [], "name": "Inositol_monoP_superfamily", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051091": {"description": "Protein O-Glucosyltransferase/Glycosyltransferase 90", "go_ids": [], "go_terms": [], "name": "O-Glucosyltr/Glycosyltrsf_90", "pathway_ids": ["PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-1912399", "PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525"], "pathways": ["PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum", "PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", 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{"description": "T cell receptor gamma variable/constant region", "go_ids": [], "go_terms": [], "name": "TRG_var/const_region", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051118": {"description": "Lateral signaling target protein 2", "go_ids": [], "go_terms": [], "name": "LST-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051119": {"description": "Nematode serpentine receptor-like", "go_ids": [], "go_terms": [], "name": "Nematode_SR-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051120": {"description": "ABC Transporter, Amino Acid and LPS Transport", "go_ids": [], "go_terms": [], "name": "ABC_AA/LPS_Transport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051121": {"description": "Fumarylacetoacetate hydrolase", "go_ids": [], "go_terms": [], "name": "FAH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051122": {"description": "SDR DHRS6-like", "go_ids": [], "go_terms": [], "name": "SDR_DHRS6-like", "pathway_ids": ["R-MMU-77111", "R-HSA-77111", "R-DRE-77111", "R-RNO-77111"], "pathways": ["R-MMU-77111:r:Synthesis of Ketone Bodies", "R-HSA-77111:r:Synthesis of Ketone Bodies", "R-DRE-77111:r:Synthesis of Ketone Bodies", "R-RNO-77111:r:Synthesis of Ketone Bodies"], "type": "Family"}, "IPR051124": {"description": "Binding-Protein-Dependent Phosphate Transport Permease", "go_ids": [], "go_terms": [], "name": "Phosphate_Transport_Permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051125": {"description": "ABC-4 integral membrane protein family, HrtB subfamily", "go_ids": [], "go_terms": [], "name": "ABC-4/HrtB_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051126": {"description": "Thiosulfate sulfurtransferase domain-containing protein", "go_ids": [], "go_terms": [], "name": "Thiosulfate_sulfurtransferase", "pathway_ids": ["PWY-7927", "PWY-5350"], "pathways": ["PWY-7927:t:sulfide oxidation IV (mitochondria)", "PWY-5350:t:thiosulfate disproportionation IV 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"R-MMU-69601", "R-HSA-380320", "R-HSA-9861718", "R-HSA-9929356", "R-MMU-383280", "R-MMU-2672351", "R-MMU-8854518", "R-MMU-9929356", "R-HSA-179409", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-HSA-9918481"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DDI-383280:r:Nuclear Receptor transcription pathway", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-MMU-2672351:r:Stimuli-sensing channels", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-9918481:r:Dengue 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"R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9758890:r:Transport of RCbl within the body", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8964038:r:LDL clearance", "R-HSA-8964026:r:Chylomicron clearance", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8964026:r:Chylomicron clearance", "R-RNO-8964026:r:Chylomicron clearance", "R-HSA-9758890:r:Transport of RCbl within the body", "R-RNO-8964038:r:LDL clearance", "R-HSA-8964038:r:LDL clearance"], "type": "Family"}, "IPR051134": {"description": "Protein Phosphatase PPP", "go_ids": [], "go_terms": [], "name": "PPP_phosphatase", "pathway_ids": ["R-SCE-8939211", "R-MMU-5693565", "R-MMU-8939211", "R-CEL-8939211", "R-HSA-2514859", "R-HSA-8939211", "R-CEL-5675221", "R-MMU-2514859", "R-RNO-5693565", "R-HSA-5693565", "R-RNO-5675221", "R-RNO-8939211", "R-RNO-2514859", "R-MMU-5675221", "R-HSA-5675221"], "pathways": 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{"description": "Intracellular Lectin and Glycoprotein Transporter", "go_ids": [], "go_terms": [], "name": "Intracellular_Lectin-GPT", "pathway_ids": ["R-HSA-9013405", "R-MMU-204005", "R-RNO-5694530", "R-HSA-948021", "R-MMU-9013106", "R-MMU-5694530", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-HSA-9013106", "R-MMU-9013404", "R-RNO-204005", "R-HSA-5694530", "R-SCE-9013106", "R-HSA-9013404", "R-HSA-9013423", "R-HSA-204005", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-8980692", "R-BTA-5694530", "R-RNO-9013408", "R-BTA-204005", "R-HSA-9013408", "R-RNO-9013106", "R-RNO-9013404"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-948021:r:Transport to the Golgi and subsequent modification", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-5694530:r:Cargo concentration in the ER", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase 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"IPR051138": {"description": "PIM Serine/Threonine Kinase", "go_ids": [], "go_terms": [], "name": "PIM_Ser/Thr_kinase", "pathway_ids": ["R-HSA-9703465", "R-BTA-9968551", "R-HSA-6785807", "R-RNO-9968551", "R-HSA-9702518", "R-HSA-9968551"], "pathways": ["R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-BTA-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9968551:r:Regulation of GBP-mediated host defense", "R-HSA-9702518:r:STAT5 activation downstream of FLT3 ITD mutants", "R-HSA-9968551:r:Regulation of GBP-mediated host defense"], "type": "Family"}, "IPR051139": {"description": "Mediator complex subunit 13", "go_ids": [], "go_terms": [], "name": "Mediator_complx_sub13", "pathway_ids": ["R-HSA-1989781", "R-DME-9841922", "R-HSA-381340", "R-HSA-9833110", "R-HSA-212436", "R-HSA-9841922"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "type": "Family"}, "IPR051141": {"description": "UPF0339 domain-containing protein", "go_ids": [], "go_terms": [], "name": "UPF0339_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051142": {"description": "Glycosyltransferase 29", "go_ids": [], "go_terms": [], "name": "Glycosyltransferase_29", "pathway_ids": ["PWY-7434", "PWY-7426", "PWY-7841", "PWY-7831", "PWY-7833", "R-HSA-1912420", "R-RNO-9037629", "R-HSA-9694719", "R-HSA-977068", "R-HSA-9694548", "R-BTA-4085001", "R-BTA-9037629", "R-MMU-975577", "R-MMU-2022854", "R-RNO-975577", "R-RNO-977068", "R-HSA-9840309", "R-HSA-2022854", "R-HSA-3656243", "R-HSA-9037629", "R-MMU-4085001", "R-RNO-9840309", "R-RNO-4085001", "R-MMU-9840309", "R-RNO-2022854", "R-HSA-975577", "R-MMU-977068", "R-HSA-9683673", "R-HSA-4085001", "R-BTA-2022854", "R-MMU-9037629"], "pathways": ["PWY-7434:t:terminal O-glycans residues modification (via type 2 precursor disaccharide)", "PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "PWY-7841:t:neolacto-series glycosphingolipids biosynthesis", "PWY-7831:t:ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide", "PWY-7833:t:biosynthesis of Lewis epitopes (H. pylori)", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-RNO-9037629:r:Lewis blood group biosynthesis", "R-HSA-9694719:r:Maturation of protein 3a", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-9694548:r:Maturation of spike protein", "R-BTA-4085001:r:Sialic acid metabolism", "R-BTA-9037629:r:Lewis blood group biosynthesis", "R-MMU-975577:r:N-Glycan antennae elongation", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-RNO-975577:r:N-Glycan antennae elongation", "R-RNO-977068:r:Termination of O-glycan biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-3656243:r:Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-MMU-4085001:r:Sialic acid metabolism", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-4085001:r:Sialic acid metabolism", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-HSA-975577:r:N-Glycan antennae elongation", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-9683673:r:Maturation of protein 3a", "R-HSA-4085001:r:Sialic acid metabolism", "R-BTA-2022854:r:Keratan sulfate biosynthesis", "R-MMU-9037629:r:Lewis blood group biosynthesis"], "type": "Family"}, "IPR051143": {"description": "TrkH Potassium Transport", "go_ids": [], "go_terms": [], "name": "TrkH_K-transport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051144": {"description": "Formin homology domain-containing protein", "go_ids": [], "go_terms": [], "name": "Formin_homology_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051145": {"description": "Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent", "go_ids": [], "go_terms": [], "name": "GAS-SHBG-PROS", "pathway_ids": ["R-BTA-140837", "R-HSA-159782", "R-MMU-159740", "R-HSA-140837", "R-RNO-159782", "R-HSA-9918485", "R-RNO-140875", "R-BTA-159782", "R-MMU-8957275", "R-RNO-114608", "R-BTA-202733", "R-RNO-140837", "R-HSA-114608", "R-BTA-114608", "R-HSA-977606", "R-RNO-202733", "R-RNO-8957275", "R-MMU-202733", "R-MMU-381426", "R-MMU-159763", "R-RNO-159740", "R-HSA-381426", "R-BTA-159740", "R-HSA-159763", "R-BTA-140875", "R-RNO-159763", "R-MMU-140837", "R-HSA-140875", "R-MMU-140875", "R-RNO-381426", "R-HSA-159740", "R-MMU-159782", "R-HSA-8957275", "R-BTA-159763", "R-HSA-202733", "R-MMU-114608"], "pathways": ["R-BTA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-RNO-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-RNO-140875:r:Common Pathway of Fibrin Clot Formation", "R-BTA-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-114608:r:Platelet degranulation", "R-BTA-114608:r:Platelet degranulation", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-BTA-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-MMU-159782:r:Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-BTA-159763:r:Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR051147": {"description": "Cilia- and flagella-associated domain-containing protein", "go_ids": [], "go_terms": [], "name": "CFAP_domain-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051148": {"description": "Zona Pellucida Domain Glycoprotein", "go_ids": [], "go_terms": [], "name": "Zona_Pellucida_Domain_gp", "pathway_ids": ["R-MMU-2534343", "R-BTA-2534343", "R-SSC-2534343", "R-HSA-2534343"], "pathways": ["R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-BTA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-SSC-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-HSA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida"], "type": "Family"}, "IPR051149": {"description": "Spindly/BICDR Dynein Motor Adapter", "go_ids": [], "go_terms": [], "name": "Spindly/BICDR_Dynein_Adapter", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-HSA-2500257", "R-MMU-141444", "R-HSA-2467813", "R-RNO-2500257", "R-DRE-2500257", "R-MMU-2467813", "R-HSA-141444", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-RNO-5663220", "R-HSA-9648025", "R-HSA-68877", "R-RNO-9648025", "R-RNO-2467813", "R-DRE-5663220", "R-HSA-5663220", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-68877:r:Mitotic Prometaphase", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR051150": {"description": "SWT21/TCAB1 mRNA Splicing and Telomere Maintenance", "go_ids": [], "go_terms": [], "name": "SWT21/TCAB1_mRNA_Telomere", "pathway_ids": ["R-RNO-171319", "R-HSA-390471", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Family"}, "IPR051151": {"description": "Group II amino acid decarboxylase", "go_ids": [], "go_terms": [], "name": "Group_II_decarboxylase", "pathway_ids": ["PWY-6173"], "pathways": ["PWY-6173:t:histamine biosynthesis"], "type": "Family"}, "IPR051152": {"description": "Caenorhabditis elegans Orphan Nuclear Receptors", "go_ids": [], "go_terms": [], "name": "C.elegans_Orphan_NR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051153": {"description": "Yeast Cell Wall Mannoprotein PIR", "go_ids": [], "go_terms": [], "name": "Yeast_CWMannoprotein_PIR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051154": {"description": "Prespore-cell-inducing factor", "go_ids": [], "go_terms": [], "name": "Prespore-cell_inducing_factor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051155": {"description": "Nematode Major Sperm", "go_ids": [], "go_terms": [], "name": "Nematode_MSP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051156": {"description": "Mitochondrial and Outer Membrane Metalloprotease", "go_ids": [], "go_terms": [], "name": "Mito/Outer_Membr_Metalloprot", "pathway_ids": ["R-SCE-9840373", "R-HSA-9840373", "R-SCE-169911", "R-SPO-169911", "R-HSA-169911", "R-BTA-169911", "R-SPO-9840373", "R-RNO-9840373", "R-HSA-9837999", "R-DRE-9840373", "R-RNO-169911", "R-MMU-169911", "R-MMU-9840373", "R-DRE-169911", "R-BTA-9840373"], "pathways": ["R-SCE-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9840373:r:Cellular response to mitochondrial stress", "R-SCE-169911:r:Regulation of Apoptosis", "R-SPO-169911:r:Regulation of Apoptosis", "R-HSA-169911:r:Regulation of Apoptosis", "R-BTA-169911:r:Regulation of Apoptosis", "R-SPO-9840373:r:Cellular response to mitochondrial stress", "R-RNO-9840373:r:Cellular response to mitochondrial stress", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-DRE-9840373:r:Cellular response to mitochondrial stress", "R-RNO-169911:r:Regulation of Apoptosis", "R-MMU-169911:r:Regulation of Apoptosis", "R-MMU-9840373:r:Cellular response to mitochondrial stress", "R-DRE-169911:r:Regulation of Apoptosis", "R-BTA-9840373:r:Cellular response to mitochondrial stress"], "type": "Family"}, "IPR051157": {"description": "Pyruvate Dehydrogenase/Transketolase", "go_ids": [], "go_terms": [], "name": "PDH/Transketolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051158": {"description": "Metallophosphoesterase-like", "go_ids": [], "go_terms": [], "name": "Metallophosphoesterase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051159": {"description": "Hexapeptide-repeat containing acetyltransferases", "go_ids": [], "go_terms": [], "name": "Hexapeptide_acetyltransf", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin 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"PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR051161": {"description": "Mannose-6-phosphate isomerase type 2", "go_ids": [], "go_terms": [], "name": "Mannose-6P_isomerase_type2", "pathway_ids": ["PWY-5659"], "pathways": ["PWY-5659:t:GDP-mannose biosynthesis"], "type": "Family"}, "IPR051163": {"description": "Sodium:Solute Symporter (SSF)", "go_ids": [], "go_terms": [], "name": "Sodium:Solute_Symporter_SSF", "pathway_ids": ["R-MMU-196807", "R-RNO-209968", "R-XTR-9958790", "R-DRE-196807", "R-HSA-9958790", "R-MMU-9958790", "R-HSA-196807", "R-HSA-196780", "R-HSA-199220", "R-HSA-5619096", "R-BTA-428643", "R-MMU-199220", "R-HSA-428643", "R-MMU-196780", "R-MMU-425397", "R-RNO-199220", "R-HSA-425397", "R-HSA-209968", "R-RNO-196780", "R-XTR-196807", "R-XTR-428643", "R-RNO-425397", "R-DRE-428643", "R-MMU-209968", 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"Family"}, "IPR051165": {"description": "Multifunctional Ankyrin Repeat Domain-Containing Protein", "go_ids": [], "go_terms": [], "name": "Multifunctional_ANK_Repeat", "pathway_ids": ["R-HSA-447043", "R-HSA-9013405", "R-HSA-9768727", "R-MMU-445095", "R-HSA-445095", "R-RNO-8951664", "R-HSA-6807878", "R-MMU-6807878", "R-RNO-983168", "R-HSA-447038", "R-MMU-447043", "R-HSA-447041"], "pathways": ["R-HSA-447043:r:Neurofascin interactions", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-445095:r:Interaction between L1 and Ankyrins", "R-HSA-445095:r:Interaction between L1 and Ankyrins", "R-RNO-8951664:r:Neddylation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-447038:r:NrCAM interactions", "R-MMU-447043:r:Neurofascin interactions", 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"R-MMU-9013420", "R-RNO-170968", "R-DME-3928664", "R-MMU-8849471", "R-MMU-186763", "R-HSA-170984", "R-GGA-8875555", "R-HSA-373753", "R-DME-5663213", "R-MMU-170968", "R-HSA-983695", "R-HSA-3928664", "R-HSA-2029482", "R-MMU-373753", "R-MMU-8875555", "R-RNO-8875656", "R-MMU-170984", "R-CEL-186763", "R-RNO-8875555", "R-HSA-372708", "R-RNO-4420097", "R-HSA-202433", "R-GGA-4420097", "R-HSA-418885", "R-DME-9013424", "R-RNO-9027284", "R-RNO-2029482", "R-GGA-186763", "R-MMU-372708", "R-RNO-170984", "R-MMU-9027284", "R-MMU-3928664", "R-GGA-912631", "R-RNO-8849471", "R-MMU-202433", "R-HSA-9013420", "R-MMU-912631", "R-HSA-8985801", "R-MMU-9013424", "R-HSA-9679191", "R-MMU-983695", "R-MMU-2029482", "R-HSA-186763", "R-DME-9833482", "R-GGA-170984", "R-CEL-4420097", "R-MMU-8875656", "R-HSA-170968", "R-CEL-8849471", "R-HSA-428540", "R-DME-8849471", "R-HSA-8875656", "R-DME-186763", "R-HSA-9664422", "R-RNO-186763", "R-GGA-372708", "R-DME-9013420", "R-MMU-418885"], "pathways": ["R-HSA-5663213:r:RHO 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attractive signaling"], "type": "Family"}, "IPR051185": {"description": "Abnormal Spindle-like Microcephaly-associated", "go_ids": [], "go_terms": [], "name": "ASPM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051186": {"description": "RRM HNRPC family, RALY subfamily", "go_ids": [], "go_terms": [], "name": "RRM_HNRPC/RALY_subfam", "pathway_ids": ["R-HSA-72203", "R-HSA-9013422", "R-HSA-9013418", "R-HSA-9770562", "R-RNO-9013422", "R-RNO-72203", "R-MMU-72203", "R-MMU-9770562", "R-MMU-72163", "R-MMU-4570464", "R-RNO-72163", "R-HSA-72163", "R-SPO-9770562", "R-MMU-9013422", "R-SPO-4570464", "R-RNO-4570464", "R-RNO-9770562", "R-HSA-4570464", "R-MMU-9013418", "R-SPO-72163", "R-HSA-9918481", "R-SCE-72203", "R-RNO-9013418", "R-SPO-72203"], "pathways": ["R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", 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{"description": "Pre-mRNA 3'-end-processing regulator", "go_ids": [], "go_terms": [], "name": "Pre-mRNA_3'-end_processing_reg", "pathway_ids": ["R-HSA-9770562", "R-HSA-9673766", "R-DRE-77595", "R-MMU-9770562", "R-MMU-77595", "R-HSA-73856", "R-RNO-77595", "R-MMU-73856", "R-HSA-72187", "R-HSA-159231", "R-RNO-73856", "R-HSA-77595", "R-DRE-73856", "R-MMU-72187", "R-DRE-9770562", "R-RNO-159231", "R-RNO-9770562", "R-HSA-9918481", "R-MMU-159231"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9673766:r:Signaling by cytosolic PDGFRA and PDGFRB fusion proteins", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless 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"PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Family"}, "IPR051219": {"description": "Heterochromatin-associated chromo domain-containing protein", "go_ids": [], "go_terms": [], "name": "Heterochromatin_chromo-domain", "pathway_ids": ["R-CEL-983231", "R-MMU-8953750", "R-HSA-73772", "R-HSA-8953750", "R-DME-9843940", "R-HSA-9609690", "R-DME-983231", "R-HSA-983231", "R-HSA-9843940", "R-DME-8953750", "R-HSA-427389", "R-MMU-983231", "R-DME-73772", "R-HSA-4551638"], "pathways": 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{"description": "Tail Fiber Assembly Chaperone", "go_ids": [], "go_terms": [], "name": "TFA_Chaperone", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051221": {"description": "Low-density lipoprotein receptor-related", "go_ids": [], "go_terms": [], "name": "LDLR-related", "pathway_ids": ["R-MMU-8856828", "R-BTA-8964026", "R-MMU-8964046", "R-MMU-8856825", "R-HSA-3000178", "R-HSA-8856828", "R-RNO-8866376", "R-HSA-2168880", "R-HSA-432142", "R-RNO-8964026", "R-GGA-8866376", "R-RNO-8964038", "R-HSA-8964046", "R-MMU-432142", "R-MMU-975634", "R-RNO-9758890", "R-HSA-196791", "R-MMU-8964038", "R-RNO-8856828", "R-RNO-975634", "R-MMU-2168880", "R-RNO-8964046", "R-RNO-8866427", "R-BTA-8856828", "R-RNO-8856825", "R-RNO-2168880", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9758890", "R-BTA-8856825", "R-HSA-8866427", "R-RNO-196791", "R-GGA-8866427", "R-BTA-8964038", "R-HSA-8856825", "R-MMU-8866376", "R-MMU-9758890", "R-MMU-8866427", "R-HSA-8866376", "R-HSA-8964038", "R-HSA-975634"], 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Termination", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-73856:r:RNA Polymerase II Transcription Termination", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-BTA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-72187:r:mRNA 3'-end processing", "R-BTA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-BTA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR051230": {"description": "Amyloid-beta A4 Precursor Protein-Binding", "go_ids": [], "go_terms": [], "name": "APP-Binding", "pathway_ids": ["R-HSA-5213460", "R-MMU-5213460", "R-RNO-212676", "R-MMU-6798695", "R-RNO-5213460", "R-RNO-5675482", "R-HSA-9609736", "R-RNO-6798695", "R-MMU-3928664", "R-HSA-447043", "R-HSA-6798695", "R-MMU-212676", "R-HSA-3928664", "R-HSA-5675482", "R-RNO-447043", "R-MMU-5675482", "R-HSA-212676", "R-CEL-212676", "R-RNO-3928664", "R-MMU-447043", "R-HSA-6794361"], "pathways": ["R-HSA-5213460:r:RIPK1-mediated regulated necrosis", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-3928664:r:Ephrin signaling", "R-HSA-447043:r:Neurofascin interactions", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-3928664:r:Ephrin signaling", "R-HSA-5675482:r:Regulation of necroptotic cell death", "R-RNO-447043:r:Neurofascin interactions", "R-MMU-5675482:r:Regulation of necroptotic cell death", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-3928664:r:Ephrin signaling", "R-MMU-447043:r:Neurofascin interactions", "R-HSA-6794361:r:Neurexins and neuroligins"], "type": "Family"}, "IPR051231": {"description": "SOSS complex subunit B", "go_ids": [], "go_terms": [], "name": "SOSS-B", "pathway_ids": ["R-DME-6807505", "R-HSA-6807505", "R-RNO-6807505", "R-XTR-6807505", "R-BTA-6807505", "R-MMU-6807505", "R-DRE-6807505", "R-DDI-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-RNO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-XTR-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR051233": {"description": "Desulfoferrodoxin superoxide reductase", "go_ids": [], "go_terms": [], "name": "Desulfoferrodoxin_SOR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051234": {"description": "TAO Serine/Threonine-Protein Kinase", "go_ids": [], "go_terms": [], "name": "TAO_STE20_kinase", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-2500257", "R-MMU-2467813", "R-HSA-141444", "R-RNO-9013149", "R-MMU-68877", "R-HSA-9648025", "R-MMU-9013404", "R-RNO-5663220", "R-CEL-9013149", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-9013404", "R-HSA-68877", "R-MMU-9013149", "R-RNO-9648025", "R-RNO-2467813", "R-RNO-9013404", "R-HSA-5663220", "R-HSA-9920951", "R-MMU-9648025", "R-MMU-5663220", "R-RNO-141444", "R-CEL-9013423"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-9013423:r:RAC3 GTPase cycle"], "type": "Family"}, "IPR051235": {"description": "Centrosomal Protein 152/SHC-Transforming Protein", "go_ids": [], "go_terms": [], "name": "CEP152/SHC-Transforming", "pathway_ids": ["R-MMU-180336", "R-RNO-1250347", "R-MMU-9674555", "R-BTA-5654719", "R-RNO-9020558", "R-BTA-5673001", "R-HSA-2871796", "R-RNO-5654704", "R-MMU-74749", "R-RNO-2428933", "R-HSA-380284", "R-RNO-9009391", "R-MMU-210993", "R-MMU-9009391", "R-RNO-74749", "R-HSA-9027284", "R-HSA-9026519", "R-HSA-8854518", "R-MMU-2565942", "R-RNO-8983432", "R-MMU-380320", "R-RNO-512988", "R-RNO-2871809", "R-MMU-2871796", "R-HSA-4420097", "R-HSA-380320", "R-MMU-201556", "R-RNO-912526", "R-RNO-9634597", "R-MMU-8851805", "R-HSA-8853659", "R-BTA-2871809", "R-BTA-8853659", "R-BTA-9020558", "R-MMU-9020558", "R-MMU-74751", "R-HSA-512988", "R-BTA-9674555", "R-MMU-5620912", "R-HSA-9664565", "R-RNO-5673001", "R-MMU-5673001", "R-BTA-9634597", "R-MMU-4420097", "R-MMU-2428933", "R-MMU-167044", "R-RNO-201556", "R-HSA-9665686", "R-MMU-380259", "R-RNO-210993", "R-HSA-210993", "R-RNO-8853659", "R-HSA-2424491", "R-BTA-74751", "R-MMU-9634597", "R-MMU-8853659", "R-MMU-380270", "R-HSA-8983432", "R-BTA-8983432", "R-HSA-5637810", "R-HSA-5673001", "R-HSA-5654699", "R-MMU-912526", "R-RNO-5654688", "R-RNO-8851805", "R-RNO-2730905", "R-MMU-8854518", "R-MMU-2730905", "R-MMU-1250196", "R-BTA-354192", "R-HSA-9674555", "R-MMU-5654688", "R-BTA-8851805", "R-HSA-5654704", "R-MMU-354192", "R-BTA-2424491", "R-RNO-4420097", "R-HSA-9680350", "R-RNO-2871796", "R-RNO-5654699", "R-HSA-9634597", "R-BTA-5654688", "R-HSA-167044", "R-RNO-9674555", "R-RNO-9842663", "R-HSA-74751", "R-MMU-5654699", "R-HSA-9665348", "R-HSA-2428933", "R-MMU-380284", "R-HSA-1250347", "R-RNO-9027284", "R-MMU-9842663", "R-HSA-2565942", "R-RNO-167044", "R-RNO-5654719", "R-BTA-1250347", "R-BTA-201556", "R-RNO-354192", "R-BTA-912526", "R-MMU-5654704", "R-HSA-1236382", "R-MMU-1250347", "R-BTA-2871796", "R-MMU-512988", "R-HSA-1250196", "R-HSA-2730905", "R-BTA-180336", "R-HSA-5654719", "R-HSA-5620912", "R-HSA-8851805", "R-MMU-5654719", "R-MMU-9027284", "R-BTA-512988", "R-HSA-9020558", "R-HSA-354192", "R-BTA-5654704", "R-HSA-381038", "R-BTA-5654699", "R-BTA-2428933", "R-BTA-1250196", "R-HSA-2871809", "R-HSA-9034864", "R-HSA-380270", "R-HSA-9842663", "R-HSA-74749", "R-MMU-8983432", "R-BTA-9009391", "R-BTA-74749", "R-HSA-180336", "R-BTA-2730905", "R-HSA-9009391", "R-RNO-74751", "R-RNO-2424491", "R-HSA-9634285", "R-MMU-2871809", "R-HSA-912526", "R-HSA-201556", "R-BTA-167044", "R-RNO-180336", "R-MMU-2424491", "R-BTA-210993", "R-RNO-1250196", "R-BTA-9027284", "R-HSA-380259", "R-HSA-9725370", "R-HSA-5654688"], "pathways": ["R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-BTA-5654719:r:SHC-mediated cascade:FGFR4", "R-RNO-9020558:r:Interleukin-2 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activation", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-201556:r:Signaling by ALK", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-RNO-9634597:r:GPER1 signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-HSA-8853659:r:RET signaling", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-BTA-8853659:r:RET signaling", "R-BTA-9020558:r:Interleukin-2 signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-BTA-9634597:r:GPER1 signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-167044:r:Signalling to RAS", "R-RNO-201556:r:Signaling by ALK", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-210993:r:Tie2 Signaling", "R-HSA-210993:r:Tie2 Signaling", "R-RNO-8853659:r:RET signaling", "R-HSA-2424491:r:DAP12 signaling", "R-BTA-74751:r:Insulin receptor signalling cascade", "R-MMU-9634597:r:GPER1 signaling", "R-MMU-8853659:r:RET signaling", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-8983432:r:Interleukin-15 signaling", "R-BTA-8983432:r:Interleukin-15 signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-RNO-5654688:r:SHC-mediated cascade:FGFR1", "R-RNO-8851805:r:MET activates RAS signaling", "R-RNO-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-BTA-354192:r:Integrin signaling", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-BTA-8851805:r:MET activates RAS signaling", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-MMU-354192:r:Integrin signaling", "R-BTA-2424491:r:DAP12 signaling", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-RNO-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9634597:r:GPER1 signaling", "R-BTA-5654688:r:SHC-mediated cascade:FGFR1", "R-HSA-167044:r:Signalling to RAS", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-9842663:r:Signaling by LTK", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-9842663:r:Signaling by LTK", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-167044:r:Signalling to RAS", "R-RNO-5654719:r:SHC-mediated cascade:FGFR4", "R-BTA-1250347:r:SHC1 events in ERBB4 signaling", "R-BTA-201556:r:Signaling by ALK", "R-RNO-354192:r:Integrin signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-BTA-180336:r:SHC1 events in EGFR signaling", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-HSA-354192:r:Integrin signaling", "R-BTA-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-BTA-5654699:r:SHC-mediated cascade:FGFR2", "R-BTA-2428933:r:SHC-related events triggered by IGF1R", "R-BTA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-9842663:r:Signaling by LTK", "R-HSA-74749:r:Signal attenuation", "R-MMU-8983432:r:Interleukin-15 signaling", "R-BTA-9009391:r:Extra-nuclear estrogen signaling", "R-BTA-74749:r:Signal attenuation", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-74751:r:Insulin receptor signalling cascade", "R-RNO-2424491:r:DAP12 signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-201556:r:Signaling by ALK", "R-BTA-167044:r:Signalling to RAS", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-MMU-2424491:r:DAP12 signaling", "R-BTA-210993:r:Tie2 Signaling", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1"], "type": "Family"}, "IPR051236": {"description": "Histone acetyltransferase RTT109-like", "go_ids": [], "go_terms": [], "name": "HAT_RTT109-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051238": {"description": "GDSL esterase/lipase", "go_ids": [], "go_terms": [], "name": "GDSL_esterase/lipase", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-8391:t:D-galacturonate degradation III", "PWY-8390:t:D-glucuronate degradation III", "PWY-6308:t:L-cysteine biosynthesis II (tRNA-dependent)", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8384:t:vitamin B6 degradation II", "PWY-7002:t:4-hydroxyacetophenone degradation", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-8455:t:misacylated tRNA editing", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6415:t:L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-5835:t:geranyl acetate biosynthesis", "PWY-7982:t:pinoresinol degradation", "PWY-7712:t:deoxynivalenol biosynthesis", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8143:t:L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)", "PWY-7521:t:3-(4-sulfophenyl)butanoate degradation"], "type": "Family"}, "IPR051239": {"description": "2'-Deoxynucleoside 5'-phosphate N-hydrolase", "go_ids": [], "go_terms": [], "name": "2'-dNMP_N-hydrolase", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106", "R-HSA-74259", "R-MMU-74259", "R-RNO-74259", "R-DRE-74259"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)", "R-HSA-74259:r:Purine catabolism", "R-MMU-74259:r:Purine catabolism", "R-RNO-74259:r:Purine catabolism", "R-DRE-74259:r:Purine catabolism"], "type": "Family"}, "IPR051240": {"description": "Mitochondrial RNA Processing and Respiration", "go_ids": [], "go_terms": [], "name": "Mito_RNA-Proc/Resp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051241": {"description": "DZIP and RILPL", "go_ids": [], "go_terms": [], "name": "DZIP_RILPL", "pathway_ids": ["R-HSA-2132295", "R-MMU-5632684", "R-DME-5632684", "R-HSA-5632684", "R-MMU-2132295", "R-DRE-5632684"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-DRE-5632684:r:Hedgehog 'on' state"], "type": "Family"}, "IPR051242": {"description": "WD repeat and EF-hand domain-containing protein", "go_ids": [], "go_terms": [], "name": "WD-EF-hand_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051243": {"description": "Polycomb group WD repeat-containing protein", "go_ids": [], "go_terms": [], "name": "PcG_WD-repeat", "pathway_ids": ["R-MMU-8953750", "R-MMU-3214841", "R-BTA-2559580", "R-HSA-2559580", "R-DRE-2559580", "R-BTA-9909649", "R-XTR-212300", "R-XTR-9764725", "R-BTA-9764725", "R-DRE-8953750", "R-HSA-9764725", "R-MMU-212300", "R-HSA-9609690", "R-HSA-8953750", "R-BTA-3214841", "R-MMU-9764725", "R-MMU-2559580", "R-MMU-8943724", "R-XTR-8953750", "R-HSA-9710421", "R-HSA-212300", "R-HSA-9909649", "R-XTR-9909649", "R-HSA-3214841", "R-DRE-3214841", "R-DRE-9764725", "R-MMU-9909649", "R-CEL-8943724", "R-HSA-8943724", "R-XTR-2559580", "R-CEL-8953750", "R-BTA-8953750", "R-DRE-212300", "R-DRE-9909649", "R-HSA-5617472", "R-BTA-212300", "R-BTA-8943724"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-BTA-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-BTA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-3214841:r:PKMTs methylate histone lysines", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9710421:r:Defective pyroptosis", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-CEL-8953750:r:Transcriptional Regulation by E2F6", "R-BTA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-BTA-212300:r:PRC2 methylates histones and DNA", "R-BTA-8943724:r:Regulation of PTEN gene transcription"], "type": "Family"}, "IPR051244": {"description": "TRPM8 Channel-Associated Factors", "go_ids": [], "go_terms": [], "name": "TCAF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051245": {"description": "eIF5-mimic translation initiation regulator", "go_ids": [], "go_terms": [], "name": "eIF5-mimic_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051246": {"description": "WD repeat-containing protein 48", "go_ids": [], "go_terms": [], "name": "WDR48", "pathway_ids": ["R-GGA-6783310", "R-DME-110314", "R-DRE-5689880", "R-XTR-110314", "R-HSA-9673766", "R-HSA-5689880", "R-GGA-110314", "R-HSA-6783310", "R-MMU-6783310", "R-CEL-5689880", "R-GGA-5689880", "R-MMU-5689880", "R-MMU-110314", "R-DRE-6783310", "R-DRE-110314", "R-XTR-5689880", "R-DDI-5689880", "R-DME-5689880", "R-HSA-110314"], "pathways": ["R-GGA-6783310:r:Fanconi Anemia Pathway", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DRE-5689880:r:Ub-specific processing proteases", "R-XTR-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-9673766:r:Signaling by cytosolic PDGFRA and PDGFRB fusion proteins", "R-HSA-5689880:r:Ub-specific processing proteases", "R-GGA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-CEL-5689880:r:Ub-specific processing proteases", "R-GGA-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DRE-6783310:r:Fanconi Anemia Pathway", "R-DRE-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-XTR-5689880:r:Ub-specific processing proteases", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex"], "type": "Family"}, "IPR051247": {"description": "RISC Loading Complex Component", "go_ids": [], "go_terms": [], "name": "RLC_Component", "pathway_ids": ["R-BTA-203927", "R-HSA-426486", "R-RNO-203927", "R-HSA-9833482", "R-DRE-9833482", "R-MMU-426486", "R-DME-9833482", "R-MMU-9833482", "R-RNO-426486", "R-MMU-203927", "R-DME-203927", "R-BTA-426486", "R-HSA-203927", "R-BTA-9833482", "R-RNO-9833482", "R-DME-426486"], "pathways": ["R-BTA-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-RNO-203927:r:MicroRNA (miRNA) biogenesis", "R-HSA-9833482:r:PKR-mediated signaling", "R-DRE-9833482:r:PKR-mediated signaling", "R-MMU-426486:r:Small interfering RNA (siRNA) biogenesis", "R-DME-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-RNO-426486:r:Small interfering RNA (siRNA) biogenesis", "R-MMU-203927:r:MicroRNA (miRNA) biogenesis", "R-DME-203927:r:MicroRNA (miRNA) biogenesis", "R-BTA-426486:r:Small interfering RNA (siRNA) biogenesis", "R-HSA-203927:r:MicroRNA (miRNA) biogenesis", "R-BTA-9833482:r:PKR-mediated signaling", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-426486:r:Small interfering RNA (siRNA) biogenesis"], "type": "Family"}, "IPR051248": {"description": "UPF0507/Ankyrin repeat domain-containing protein 27", "go_ids": [], "go_terms": [], "name": "UPF0507/Ank_repeat_27", "pathway_ids": ["R-DDI-8876198", "R-HSA-8876198", "R-MMU-8876198"], "pathways": ["R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR051249": {"description": "NLRP Inflammasome", "go_ids": [], "go_terms": [], "name": "NLRP_Inflammasome", "pathway_ids": ["R-HSA-844456", "R-HSA-6798695", "R-DRE-844455", "R-MMU-844455", "R-HSA-9660826", "R-RNO-844455", "R-DRE-111458", "R-HSA-111458", "R-MMU-844456", "R-DRE-844456", "R-DRE-9627069", "R-HSA-5660668", "R-DRE-6798695", "R-HSA-9692916", "R-MMU-6798695", "R-HSA-9627069", "R-HSA-844615", "R-HSA-844455", "R-MMU-5660668"], "pathways": ["R-HSA-844456:r:The NLRP3 inflammasome", "R-HSA-6798695:r:Neutrophil degranulation", "R-DRE-844455:r:The NLRP1 inflammasome", "R-MMU-844455:r:The NLRP1 inflammasome", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-RNO-844455:r:The NLRP1 inflammasome", "R-DRE-111458:r:Formation of apoptosome", "R-HSA-111458:r:Formation of apoptosome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-DRE-844456:r:The NLRP3 inflammasome", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-HSA-5660668:r:CLEC7A/inflammasome pathway", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-844615:r:The AIM2 inflammasome", "R-HSA-844455:r:The NLRP1 inflammasome", "R-MMU-5660668:r:CLEC7A/inflammasome pathway"], "type": "Family"}, "IPR051251": {"description": "Ser/Thr-Protein Kinase & FNIP Repeat-Containing Protein", "go_ids": [], "go_terms": [], "name": "STK_FNIP-Repeat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051252": {"description": "IS1 element transposase InsA", "go_ids": [], "go_terms": [], "name": "IS1_transposase_InsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051253": {"description": "11-beta-hydroxysteroid dehydrogenase", "go_ids": [], "go_terms": [], "name": "11-beta-HSD", "pathway_ids": ["R-RNO-9757110", "R-DRE-9757110", "R-HSA-9757110", "R-RNO-194002", "R-DRE-194002", "R-MMU-194002", "R-MMU-9757110", "R-HSA-194002"], "pathways": ["R-RNO-9757110:r:Prednisone ADME", "R-DRE-9757110:r:Prednisone ADME", "R-HSA-9757110:r:Prednisone ADME", "R-RNO-194002:r:Glucocorticoid biosynthesis", "R-DRE-194002:r:Glucocorticoid biosynthesis", "R-MMU-194002:r:Glucocorticoid biosynthesis", "R-MMU-9757110:r:Prednisone ADME", "R-HSA-194002:r:Glucocorticoid biosynthesis"], "type": "Family"}, "IPR051254": {"description": "Protein Phosphatase 1 Regulatory Subunit 15", "go_ids": [], "go_terms": [], "name": "PPP1R15", "pathway_ids": ["R-HSA-9648895", "R-HSA-2173788"], "pathways": ["R-HSA-9648895:r:Response of EIF2AK1 (HRI) to heme deficiency", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling"], "type": "Family"}, "IPR051255": {"description": "Retroviral envelope glycoprotein", "go_ids": [], "go_terms": [], "name": "Retroviral_env_glycoprotein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051256": {"description": "Dictomallein", "go_ids": [], "go_terms": [], "name": "Dictomallein", "pathway_ids": ["PWY-8119"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis"], "type": "Family"}, "IPR051257": {"description": "Diverse Function CBS-Domain-Containing Protein", "go_ids": [], "go_terms": [], "name": "Diverse_CBS-Domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051258": {"description": "Diverse Substrate Transporter", "go_ids": [], "go_terms": [], "name": "Diverse_Substrate_Transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051259": {"description": "Ribosomal RNA Methyltransferase", "go_ids": [], "go_terms": [], "name": "rRNA_Methyltransferase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-6793080"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Family"}, "IPR051260": {"description": "Diverse substrate monooxygenases", "go_ids": [], "go_terms": [], "name": "Diverse_substr_monoxygenases", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051261": {"description": "NOD-like receptor", "go_ids": [], "go_terms": [], "name": "NLR", "pathway_ids": ["R-HSA-3270619", "R-HSA-9020702", "R-RNO-9758274", "R-BTA-5689896", "R-HSA-9705671", "R-HSA-168928", "R-MMU-450302", "R-HSA-168638", "R-HSA-5689896", "R-HSA-9758274", "R-HSA-936440", "R-MMU-450321", "R-MMU-5689896", "R-HSA-450321", "R-BTA-450321", "R-BTA-450302", "R-RNO-936440", "R-HSA-450302", "R-MMU-936440", "R-MMU-168638", "R-MMU-9758274", "R-BTA-168638", "R-HSA-445989"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation"], "type": "Family"}, "IPR051263": {"description": "Cytochrome c-type biogenesis", "go_ids": [], "go_terms": [], "name": "C-type_cytochrome_biogenesis", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051264": {"description": "FAD-binding Oxidoreductase/Transferase Type 4", "go_ids": [], "go_terms": [], "name": "FAD-oxidored/transferase_4", "pathway_ids": ["PWY-5283", "R-SPO-880009", "R-DRE-880009", "R-HSA-880009", "R-MMU-880009", "R-SCE-880009", "R-RNO-880009", "R-BTA-880009"], "pathways": ["PWY-5283:t:L-lysine degradation V", "R-SPO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DRE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-SCE-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "type": "Family"}, "IPR051265": {"description": "HIBADH-related NP60 subfamily", "go_ids": [], "go_terms": [], "name": "HIBADH-related_NP60_sf", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051266": {"description": "Calcium-activated chloride channel regulator", "go_ids": [], "go_terms": [], "name": "CLCR", "pathway_ids": ["R-MMU-2672351", "R-HSA-2672351"], "pathways": ["R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR051267": {"description": "STEAP family metalloreductases", "go_ids": [], "go_terms": [], "name": "STEAP_metalloreductase", "pathway_ids": ["R-HSA-9013409", "R-HSA-9013405", "R-MMU-6803204", "R-MMU-9035034", "R-HSA-9035034", "R-HSA-6803204", "R-RNO-9035034", "R-HSA-9013148", "R-MMU-917977", "R-MMU-9013406", "R-RNO-9013406", "R-HSA-917977", "R-HSA-9013406", "R-RNO-6803204", "R-RNO-917977"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-RNO-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-RNO-917977:r:Transferrin endocytosis and recycling"], "type": "Family"}, "IPR051268": {"description": "Type I restriction enzyme R subunit", "go_ids": [], "go_terms": [], "name": "Type-I_R_enzyme_R_subunit", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051269": {"description": "Iron-sulfur cluster electron transport", "go_ids": [], "go_terms": [], "name": "Fe-S_cluster_ET", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051271": {"description": "Two-component system transcriptional regulators", "go_ids": [], "go_terms": [], "name": "2C-system_Tx_regulators", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051272": {"description": "RIO-type Ser/Thr kinase", "go_ids": [], "go_terms": [], "name": "RIO-type_Ser/Thr_kinase", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-BTA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-DDI-6791226"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR051274": {"description": "3'-5' Exoribonuclease", "go_ids": [], "go_terms": [], "name": "3-5_Exoribonuclease", "pathway_ids": ["R-MMU-6791226", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR051275": {"description": "Cellular adhesion and signaling domain-containing protein", "go_ids": [], "go_terms": [], "name": "Cell_adhesion_signaling", "pathway_ids": ["R-CEL-373753", "R-RNO-373753", "R-MMU-373753", "R-DME-373753", "R-HSA-373753"], "pathways": ["R-CEL-373753:r:Nephrin family interactions", "R-RNO-373753:r:Nephrin family interactions", "R-MMU-373753:r:Nephrin family interactions", "R-DME-373753:r:Nephrin family interactions", "R-HSA-373753:r:Nephrin family interactions"], "type": "Family"}, "IPR051276": {"description": "Saccharopine dehydrogenase-like oxidoreductase", "go_ids": [], "go_terms": [], "name": "Saccharopine_DH-like_oxidrdct", "pathway_ids": ["R-CEL-114608", "R-HSA-114608", "R-RNO-114608", "R-MMU-114608"], "pathways": ["R-CEL-114608:r:Platelet degranulation", "R-HSA-114608:r:Platelet degranulation", "R-RNO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR051277": {"description": "SEZ6/CSMD/C4BPB Neuronal & Immune Regulators", "go_ids": [], "go_terms": [], "name": "SEZ6_CSMD_C4BPB_Regulators", "pathway_ids": ["R-HSA-6798695", "R-HSA-8877330", "R-MMU-977606", "R-HSA-977606", "R-RNO-6798695", "R-RNO-977606"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8877330:r:RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-977606:r:Regulation of Complement cascade"], "type": "Family"}, "IPR051278": {"description": "CoM-S-S-CoB heterodisulfide reductase", "go_ids": [], "go_terms": [], "name": "HdrB/HdrD_reductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051279": {"description": "Protein Phosphatase 1 Regulatory and Actin Interaction Protein", "go_ids": [], "go_terms": [], "name": "PP1-Reg/Actin-Interact_Protein", "pathway_ids": ["R-HSA-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Family"}, "IPR051280": {"description": "Voltage-gated chloride channel/antiporter", "go_ids": [], "go_terms": [], "name": "Cl-channel/antiporter", "pathway_ids": ["R-HSA-2672351", "R-RNO-2672351", "R-DDI-2672351", "R-MMU-2672351", "R-HSA-6802952", "R-BTA-2672351"], "pathways": ["R-HSA-2672351:r:Stimuli-sensing channels", "R-RNO-2672351:r:Stimuli-sensing channels", "R-DDI-2672351:r:Stimuli-sensing channels", "R-MMU-2672351:r:Stimuli-sensing channels", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-BTA-2672351:r:Stimuli-sensing channels"], "type": "Family"}, "IPR051281": {"description": "Dual-specificity lipid and protein phosphatase", "go_ids": [], "go_terms": [], "name": "Dual-spec_lipid-protein_phosph", "pathway_ids": ["PWY-6368", "R-CEL-8948747", "R-DDI-5689896", "R-RNO-8948751", "R-SCE-1855204", "R-CFA-8948751", "R-HSA-5689896", "R-SCE-8948747", "R-HSA-5689880", "R-CFA-1660499", "R-DDI-8948747", "R-DDI-199418", "R-DDI-1660499", "R-MMU-8948751", "R-MMU-5689896", "R-HSA-1660499", "R-HSA-5628897", "R-DDI-202424", "R-CFA-5689880", "R-MMU-5689880", "R-DDI-1855204", "R-SCE-8948751", "R-CFA-199418", "R-HSA-199418", "R-RNO-202424", "R-MMU-1855204", "R-DDI-5689880", "R-MMU-202424", "R-RNO-8948747", "R-RNO-199418", "R-CFA-202424", "R-CEL-1855204", "R-CFA-8948747", "R-CFA-1855204", "R-HSA-8948747", "R-HSA-8943723", "R-SCE-202424", "R-SPO-1660514", "R-SCE-1660499", "R-MMU-8948747", "R-DDI-8948751", "R-HSA-1660514", "R-CEL-202424", "R-CFA-5689896", "R-MMU-1660499", "R-RNO-5689880", "R-CEL-5689880", "R-HSA-5674404", "R-RNO-1660499", "R-HSA-1855204", "R-CEL-1660499", "R-RNO-1855204", "R-SCE-199418", "R-HSA-8948751", "R-CEL-8948751", "R-MMU-199418", "R-RNO-5689896", "R-HSA-8986944", "R-HSA-202424", "R-CEL-199418", "R-CEL-5689896"], "pathways": ["PWY-6368:t:3-phosphoinositide degradation", "R-CEL-8948747:r:Regulation of PTEN 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"R-DDI-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-8948751:r:Regulation of PTEN stability and activity", "R-CFA-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-202424:r:Downstream TCR signaling", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-8948747:r:Regulation of PTEN localization", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network", "R-CFA-202424:r:Downstream TCR signaling", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CFA-8948747:r:Regulation of PTEN localization", "R-CFA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-8948747:r:Regulation of PTEN localization", "R-HSA-8943723:r:Regulation of PTEN mRNA translation", "R-SCE-202424:r:Downstream TCR signaling", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SCE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-8948747:r:Regulation of PTEN localization", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-CEL-202424:r:Downstream TCR signaling", "R-CFA-5689896:r:Ovarian tumor domain proteases", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CEL-5689880:r:Ub-specific processing proteases", "R-HSA-5674404:r:PTEN Loss of Function in Cancer", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CEL-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-SCE-199418:r:Negative regulation of the PI3K/AKT network", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-RNO-5689896:r:Ovarian tumor domain proteases", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-HSA-202424:r:Downstream TCR signaling", "R-CEL-199418:r:Negative regulation of the PI3K/AKT network", "R-CEL-5689896:r:Ovarian tumor domain proteases"], "type": "Family"}, "IPR051282": {"description": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein", "go_ids": [], "go_terms": [], "name": "Arf-GAP_GTPase_ANK_PH", "pathway_ids": ["R-HSA-373752"], "pathways": ["R-HSA-373752:r:Netrin-1 signaling"], "type": "Family"}, "IPR051283": {"description": "Secondary metabolite acyltransferase", "go_ids": [], "go_terms": [], "name": "Sec_Metabolite_Acyltrans", "pathway_ids": ["PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318"], "pathways": ["PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis"], "type": "Family"}, "IPR051284": {"description": "Zinc finger MYM-type/QRICH1", "go_ids": [], "go_terms": [], "name": "ZnF_MYMT-QRICH1", "pathway_ids": ["R-HSA-9703465", "R-HSA-9764725", "R-HSA-5655302", "R-MMU-9764725", "R-HSA-1839117"], "pathways": ["R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Family"}, "IPR051285": {"description": "NADH-dependent Oxidoreductase Modular Protein", "go_ids": [], "go_terms": [], "name": "NADH_oxidoreductase_modular", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051286": {"description": "Janus Kinase (JAK)", "go_ids": [], "go_terms": [], "name": "JAK", "pathway_ids": ["R-SSC-5673000", "R-RNO-6785807", "R-HSA-9020958", "R-HSA-6802952", "R-MMU-1266695", "R-HSA-9006335", "R-MMU-9674555", "R-RNO-9020558", "R-RNO-9020591", "R-DME-9020558", "R-SSC-912526", "R-SSC-69231", "R-HSA-9732724", "R-HSA-69231", "R-HSA-9027284", "R-RNO-512988", "R-RNO-8854691", "R-RNO-877312", "R-SSC-9020933", "R-MMU-9020958", "R-MMU-201556", "R-HSA-5673000", "R-MMU-9732724", "R-RNO-983231", "R-SSC-112411", "R-SSC-982772", "R-HSA-512988", "R-SSC-9705462", "R-SSC-1170546", "R-MMU-909733", "R-DME-209209", "R-HSA-6802955", "R-HSA-2586552", "R-SSC-9674555", "R-HSA-9027283", "R-HSA-8984722", "R-MMU-5673001", "R-HSA-9931295", "R-RNO-5673000", "R-DRE-112411", "R-HSA-1170546", "R-RNO-9732724", "R-HSA-983231", "R-MMU-5673000", "R-DME-8985947", "R-RNO-9705462", "R-DRE-909733", "R-DRE-912694", "R-HSA-8983432", "R-SSC-9027284", "R-RNO-9020958", "R-MMU-912526", "R-DRE-6785807", "R-RNO-9006335", "R-HSA-909733", "R-DRE-8983432", "R-SSC-1433557", "R-HSA-8985947", "R-MMU-6785807", "R-HSA-9656223", "R-HSA-9833109", "R-HSA-9705671", "R-HSA-1059683", "R-DRE-877312", "R-MMU-9020956", "R-HSA-6788467", "R-SSC-8854691", "R-RNO-9027284", "R-MMU-9020591", "R-HSA-877312", "R-MMU-512988", "R-RNO-6788467", "R-HSA-9027276", "R-MMU-877312", "R-HSA-9020558", "R-MMU-9027284", "R-RNO-1170546", "R-SSC-1059683", "R-SSC-9006335", "R-MMU-8983432", "R-HSA-110056", "R-RNO-69231", "R-HSA-912526", "R-HSA-877300", "R-SSC-983231", "R-HSA-201556", "R-HSA-9027277", "R-HSA-9725370", "R-DME-210688", "R-HSA-9020956", "R-MMU-8985947", "R-RNO-877300", "R-DRE-9732724", "R-SSC-9020591", "R-DRE-6783783", "R-DRE-1266695", "R-HSA-112411", "R-DME-69231", "R-MMU-9020933", "R-SSC-6785807", "R-SSC-9732724", "R-RNO-9020956", "R-HSA-9670439", "R-RNO-9027276", "R-RNO-8983432", "R-RNO-912526", "R-HSA-9649948", "R-DME-1266695", "R-MMU-9020558", "R-DRE-877300", "R-SSC-877300", "R-RNO-5673001", "R-HSA-6783783", "R-HSA-1266695", "R-DME-6785807", "R-DME-5673000", "R-RNO-201556", "R-MMU-1433557", "R-RNO-9020933", "R-SSC-8984722", "R-MMU-982772", "R-RNO-8984722", "R-HSA-9020933", "R-DRE-8854691", "R-HSA-6785807", "R-HSA-8854691", "R-SSC-512988", "R-MMU-9705462", "R-HSA-5673001", "R-HSA-982772", "R-RNO-1433557", "R-MMU-9027276", "R-HSA-9674555", "R-DRE-6788467", "R-MMU-69231", "R-HSA-449836", "R-RNO-9674555", "R-MMU-112411", "R-RNO-1059683", "R-DRE-9705462", "R-HSA-1169408", "R-MMU-983231", "R-DRE-110056", "R-HSA-3214858", "R-MMU-9931295", "R-SSC-877312", "R-HSA-6802946", "R-RNO-110056", "R-DME-983231", "R-HSA-912694", "R-MMU-6788467", "R-MMU-110056", "R-DRE-1059683", "R-MMU-8854691", "R-RNO-112411", "R-HSA-9020591", "R-MMU-1170546", "R-RNO-1266695", "R-SSC-9027276", "R-SSC-9020956", "R-MMU-8984722", "R-DRE-9020958", "R-RNO-982772", "R-HSA-9679191", "R-HSA-1433557", "R-MMU-1169408", "R-MMU-9006335", "R-MMU-877300", "R-RNO-8985947", "R-SSC-5673001", "R-MMU-1059683", "R-MMU-6783783", "R-HSA-9705462", "R-DME-209228", "R-MMU-912694", "R-SSC-6788467"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-RNO-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-1266695:r:Interleukin-7 signaling", "R-HSA-9006335:r:Signaling by Erythropoietin", "R-MMU-9674555:r:Signaling by CSF3 (G-CSF)", "R-RNO-9020558:r:Interleukin-2 signaling", "R-RNO-9020591:r:Interleukin-12 signaling", "R-DME-9020558:r:Interleukin-2 signaling", "R-SSC-912526:r:Interleukin receptor SHC signaling", "R-SSC-69231:r:Cyclin D associated events in G1", "R-HSA-9732724:r:IFNG signaling activates MAPKs", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-RNO-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-8854691:r:Interleukin-20 family signaling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-SSC-9020933:r:Interleukin-23 signaling", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-201556:r:Signaling by ALK", "R-HSA-5673000:r:RAF activation", "R-MMU-9732724:r:IFNG signaling activates MAPKs", "R-RNO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SSC-112411:r:MAPK1 (ERK2) activation", "R-SSC-982772:r:Growth hormone receptor signaling", "R-HSA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-SSC-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-SSC-1170546:r:Prolactin receptor signaling", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-DME-209209:r:Formation of the activated receptor complex", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-2586552:r:Signaling by Leptin", "R-SSC-9674555:r:Signaling by CSF3 (G-CSF)", "R-HSA-9027283:r:Erythropoietin activates STAT5", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-5673000:r:RAF activation", "R-DRE-112411:r:MAPK1 (ERK2) activation", "R-HSA-1170546:r:Prolactin receptor signaling", "R-RNO-9732724:r:IFNG signaling activates MAPKs", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5673000:r:RAF activation", "R-DME-8985947:r:Interleukin-9 signaling", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DRE-909733:r:Interferon alpha/beta signaling", "R-DRE-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-SSC-9027284:r:Erythropoietin activates RAS", "R-RNO-9020958:r:Interleukin-21 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-DRE-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-9006335:r:Signaling by Erythropoietin", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-DRE-8983432:r:Interleukin-15 signaling", "R-SSC-1433557:r:Signaling by SCF-KIT", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-1059683:r:Interleukin-6 signaling", "R-DRE-877312:r:Regulation of IFNG signaling", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-SSC-8854691:r:Interleukin-20 family signaling", "R-RNO-9027284:r:Erythropoietin activates RAS", "R-MMU-9020591:r:Interleukin-12 signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-MMU-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-RNO-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-HSA-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-MMU-877312:r:Regulation of IFNG signaling", "R-HSA-9020558:r:Interleukin-2 signaling", "R-MMU-9027284:r:Erythropoietin activates RAS", "R-RNO-1170546:r:Prolactin receptor signaling", "R-SSC-1059683:r:Interleukin-6 signaling", "R-SSC-9006335:r:Signaling by Erythropoietin", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-110056:r:MAPK3 (ERK1) activation", "R-RNO-69231:r:Cyclin D associated events in G1", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-HSA-877300:r:Interferon gamma signaling", "R-SSC-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-201556:r:Signaling by ALK", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-HSA-9020956:r:Interleukin-27 signaling", "R-MMU-8985947:r:Interleukin-9 signaling", "R-RNO-877300:r:Interferon gamma signaling", "R-DRE-9732724:r:IFNG signaling activates MAPKs", "R-SSC-9020591:r:Interleukin-12 signaling", "R-DRE-6783783:r:Interleukin-10 signaling", "R-DRE-1266695:r:Interleukin-7 signaling", "R-HSA-112411:r:MAPK1 (ERK2) activation", "R-DME-69231:r:Cyclin D associated events in G1", "R-MMU-9020933:r:Interleukin-23 signaling", "R-SSC-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-SSC-9732724:r:IFNG signaling activates MAPKs", "R-RNO-9020956:r:Interleukin-27 signaling", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-RNO-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-RNO-8983432:r:Interleukin-15 signaling", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-DME-1266695:r:Interleukin-7 signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-DRE-877300:r:Interferon gamma signaling", "R-SSC-877300:r:Interferon gamma signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-1266695:r:Interleukin-7 signaling", "R-DME-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-DME-5673000:r:RAF activation", "R-RNO-201556:r:Signaling by ALK", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-RNO-9020933:r:Interleukin-23 signaling", "R-SSC-8984722:r:Interleukin-35 Signalling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-8984722:r:Interleukin-35 Signalling", "R-HSA-9020933:r:Interleukin-23 signaling", "R-DRE-8854691:r:Interleukin-20 family signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8854691:r:Interleukin-20 family signaling", "R-SSC-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-MMU-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-1433557:r:Signaling by SCF-KIT", "R-MMU-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-HSA-9674555:r:Signaling by CSF3 (G-CSF)", "R-DRE-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-449836:r:Other interleukin signaling", "R-RNO-9674555:r:Signaling by CSF3 (G-CSF)", "R-MMU-112411:r:MAPK1 (ERK2) activation", "R-RNO-1059683:r:Interleukin-6 signaling", "R-DRE-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-DRE-110056:r:MAPK3 (ERK1) activation", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-SSC-877312:r:Regulation of IFNG signaling", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-110056:r:MAPK3 (ERK1) activation", "R-DME-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-MMU-6788467:r:IL-6-type cytokine receptor ligand interactions", "R-MMU-110056:r:MAPK3 (ERK1) activation", "R-DRE-1059683:r:Interleukin-6 signaling", "R-MMU-8854691:r:Interleukin-20 family signaling", "R-RNO-112411:r:MAPK1 (ERK2) activation", "R-HSA-9020591:r:Interleukin-12 signaling", "R-MMU-1170546:r:Prolactin receptor signaling", "R-RNO-1266695:r:Interleukin-7 signaling", "R-SSC-9027276:r:Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "R-SSC-9020956:r:Interleukin-27 signaling", "R-MMU-8984722:r:Interleukin-35 Signalling", "R-DRE-9020958:r:Interleukin-21 signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-MMU-9006335:r:Signaling by Erythropoietin", "R-MMU-877300:r:Interferon gamma signaling", "R-RNO-8985947:r:Interleukin-9 signaling", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-1059683:r:Interleukin-6 signaling", "R-MMU-6783783:r:Interleukin-10 signaling", "R-HSA-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-DME-209228:r:Formation of the activated STAT92E dimer and transport to the nucleus", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-SSC-6788467:r:IL-6-type cytokine receptor ligand interactions"], "type": "Family"}, "IPR051287": {"description": "T cell receptor variable region", "go_ids": [], "go_terms": [], "name": "TCR_variable_region", "pathway_ids": ["R-HSA-202427", "R-HSA-202424", "R-HSA-202433", "R-HSA-198933", "R-HSA-202430", "R-HSA-389948"], "pathways": ["R-HSA-202427:r:Phosphorylation of CD3 and TCR zeta chains", "R-HSA-202424:r:Downstream TCR signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-202430:r:Translocation of ZAP-70 to Immunological synapse", "R-HSA-389948:r:Co-inhibition by PD-1"], "type": "Family"}, "IPR051289": {"description": "LAGLIDADG Homing Endonuclease", "go_ids": [], "go_terms": [], "name": "LAGLIDADG_Endonuclease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051291": {"description": "Ciliary Microtubule Associated", "go_ids": [], "go_terms": [], "name": "CIMAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051292": {"description": "Alpha-1,3-xylosyltransferase/Beta-1,3-glucuronyltransferase", "go_ids": [], "go_terms": [], "name": "Xyl/GlcA_transferase", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-5381", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-6148", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-6720", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-7025", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-7817", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-9939291", "R-HSA-5083627", "R-RNO-9939291", "R-DRE-9939291", "R-MMU-9939291"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-6720:t:toyocamycin biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-5083627:r:Defective LARGE causes MDDGA6 and MDDGB6", "R-RNO-9939291:r:Matriglycan biosynthesis on DAG1", "R-DRE-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1"], "type": "Family"}, "IPR051293": {"description": "Microtubule-associated tumor suppressor/Coiled-coil domain-containing protein 69", "go_ids": [], "go_terms": [], "name": "MTUS1/CCDC69", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051294": {"description": "HORMA Domain-Containing Meiotic Progression", "go_ids": [], "go_terms": [], "name": "HORMA_MeioticProgression", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051295": {"description": "Leucine-rich glioma-inactivated/LGI-related", "go_ids": [], "go_terms": [], "name": "LGI_related", "pathway_ids": ["R-HSA-5682910", "R-RNO-5682910", "R-MMU-5682910", "R-BTA-5682910"], "pathways": ["R-HSA-5682910:r:LGI-ADAM interactions", "R-RNO-5682910:r:LGI-ADAM interactions", "R-MMU-5682910:r:LGI-ADAM interactions", "R-BTA-5682910:r:LGI-ADAM interactions"], "type": "Family"}, "IPR051296": {"description": "Cdc42 Effector Protein BORG/CEP", "go_ids": [], "go_terms": [], "name": "Cdc42_Effector_BORG/CEP", "pathway_ids": ["R-HSA-9013409", "R-MMU-9013408", "R-RNO-9013149", "R-BTA-9013406", "R-RNO-5687128", "R-MMU-9013404", "R-BTA-9013423", "R-HSA-9013404", "R-HSA-9013423", "R-BTA-9013408", "R-HSA-9013149", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-5687128", "R-MMU-9013406", "R-BTA-9013404", "R-MMU-9013149", "R-HSA-9013148", "R-RNO-9013404", "R-RNO-9013406", "R-RNO-9013408", "R-HSA-9013406", "R-HSA-9013408", "R-MMU-5687128"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-BTA-9013406:r:RHOQ GTPase cycle", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-BTA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-5687128:r:MAPK6/MAPK4 signaling"], "type": "Family"}, "IPR051297": {"description": "PalB/RIM13 Calpain-like", "go_ids": [], "go_terms": [], "name": "PalB/RIM13", "pathway_ids": ["R-HSA-1474228", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Family"}, "IPR051298": {"description": "Heme transport and cell adhesion protein", "go_ids": [], "go_terms": [], "name": "Heme_transport/Cell_adhesion", "pathway_ids": ["R-SSC-3000170", "R-HSA-9925563", "R-HSA-2129379", "R-HSA-216083", "R-HSA-3000170", "R-HSA-9920588", "R-MMU-977606", "R-HSA-3000178", "R-RNO-2168880", "R-HSA-2168880", "R-MMU-3000170", "R-SSC-977606", "R-SSC-2129379", "R-HSA-977606", "R-MMU-3000178", "R-SSC-216083", "R-MMU-216083", "R-MMU-2168880", "R-SSC-3000178", "R-MMU-2129379"], "pathways": ["R-SSC-3000170:r:Syndecan interactions", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-3000170:r:Syndecan interactions", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-3000178:r:ECM proteoglycans", "R-RNO-2168880:r:Scavenging of heme from plasma", "R-HSA-2168880:r:Scavenging of heme from plasma", "R-MMU-3000170:r:Syndecan interactions", "R-SSC-977606:r:Regulation of Complement cascade", "R-SSC-2129379:r:Molecules associated with elastic fibres", "R-HSA-977606:r:Regulation of Complement cascade", "R-MMU-3000178:r:ECM proteoglycans", "R-SSC-216083:r:Integrin cell surface interactions", "R-MMU-216083:r:Integrin cell surface interactions", "R-MMU-2168880:r:Scavenging of heme from plasma", "R-SSC-3000178:r:ECM proteoglycans", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Family"}, "IPR051299": {"description": "Alpha/beta hydrolase lipase/esterase", "go_ids": [], "go_terms": [], "name": "AB_hydrolase_lip/est", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051300": {"description": "HMX Homeobox Transcription Factors", "go_ids": [], "go_terms": [], "name": "HMX_Homeobox_TF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051301": {"description": "Optineurin/NF-kappa-B Essential Modulator", "go_ids": [], "go_terms": [], "name": "Optineurin/NFkB_EssMod", "pathway_ids": ["R-MMU-9909505", "R-RNO-9758274", "R-HSA-9020702", "R-HSA-4755510", "R-SSC-937039", "R-HSA-168638", "R-BTA-5689880", "R-HSA-9833482", "R-HSA-5689880", "R-MMU-9020702", "R-SSC-5357905", "R-BTA-975144", "R-MMU-5689896", "R-MMU-933542", "R-MMU-8854214", "R-SSC-9833482", "R-MMU-5689880", "R-BTA-450321", "R-HSA-5684264", "R-BTA-1169091", "R-HSA-168927", "R-MMU-1810476", "R-HSA-450302", "R-SSC-9909505", "R-HSA-937041", "R-SSC-2565942", "R-SSC-975144", "R-SSC-450321", "R-MMU-975144", "R-RNO-975144", "R-BTA-4755510", "R-HSA-9758274", "R-SSC-450302", "R-MMU-450321", "R-RNO-936964", "R-DRE-5205685", "R-BTA-5684264", "R-MMU-9860276", "R-RNO-5689880", "R-SSC-9860276", "R-DRE-5357905", "R-BTA-1810476", "R-DRE-8854214", "R-MMU-5357905", "R-HSA-1236974", "R-SSC-168638", "R-DME-9909505", "R-BTA-9833482", "R-MMU-9860927", "R-DME-202424", "R-HSA-9705671", "R-RNO-9860276", "R-MMU-450302", "R-SSC-936964", "R-HSA-8854214", "R-BTA-5357956", "R-HSA-933542", "R-HSA-9824878", "R-RNO-450321", "R-DME-2565942", "R-MMU-5357956", "R-RNO-9860927", "R-DME-937039", "R-BTA-2871837", "R-SSC-8854214", "R-HSA-5357905", "R-RNO-2565942", "R-SSC-933542", "R-BTA-445989", "R-SSC-9020702", "R-SSC-9860927", "R-MMU-202424", "R-MMU-9824878", "R-RNO-937041", "R-MMU-936964", "R-DME-5357905", "R-SSC-5607764", "R-MMU-1169091", "R-RNO-9824878", "R-SSC-937041", "R-SSC-202424", 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"pathways": [], "type": "Family"}, "IPR051319": {"description": "Bifunctional oligoribonuclease/pAp-phosphatase and c-di-AMP PDE", "go_ids": [], "go_terms": [], "name": "Oligoribo/pAp-PDE_c-di-AMP_PDE", "pathway_ids": ["PWY-7807", "PWY-7805"], "pathways": ["PWY-7807:t:glyphosate degradation III", "PWY-7805:t:(aminomethyl)phosphonate degradation"], "type": "Family"}, "IPR051320": {"description": "Viral Replication and Maturation Polyprotein", "go_ids": [], "go_terms": [], "name": "Viral_Replic_Matur_Polypro", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051321": {"description": "Polyhydroxyalkanoate Synthase", "go_ids": [], "go_terms": [], "name": "PHA/PHB_synthase", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR051322": {"description": "Amino Acid ABC Transporter Permease", "go_ids": [], "go_terms": [], "name": "AA_ABC_Transporter_Permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051323": {"description": "Alpha-ketoglutarate-dependent sulfate ester dioxygenase-like", "go_ids": [], "go_terms": [], "name": "AtsK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051324": {"description": "Stress and Tellurium Resistance Protein", "go_ids": [], "go_terms": [], "name": "Stress/Tellurium_Resist", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051325": {"description": "Nudix hydrolase domain-containing protein", "go_ids": [], "go_terms": [], "name": "Nudix_hydrolase_domain", "pathway_ids": ["R-HSA-3299685", "R-SSC-3299685", "R-BTA-3299685", "R-CEL-3299685", "R-MMU-3299685", "R-RNO-3299685"], "pathways": ["R-HSA-3299685:r:Detoxification of Reactive Oxygen Species", "R-SSC-3299685:r:Detoxification of Reactive Oxygen Species", "R-BTA-3299685:r:Detoxification of Reactive Oxygen Species", "R-CEL-3299685:r:Detoxification of Reactive Oxygen Species", "R-MMU-3299685:r:Detoxification of Reactive Oxygen Species", "R-RNO-3299685:r:Detoxification of Reactive Oxygen Species"], "type": "Family"}, "IPR051326": {"description": "Kynurenine--oxoglutarate transaminase", "go_ids": [], "go_terms": [], "name": "Kynurenine-oxoglutarate_AT", "pathway_ids": ["PWY-1187", "PWY-601", "PWY-6936", "PWY-801", "PWY-7901", "PWY-6842", "PWY-2821", "PWY-8302", "R-HSA-71240", "R-SPO-71240", "R-SPO-8964208", "R-HSA-8964539", "R-DDI-8964539", "R-SPO-8964539", "R-RNO-8964208", "R-RNO-8964539", "R-SCE-71240", "R-MMU-8964539", "R-MMU-71240", "R-HSA-8964208", "R-SCE-8964539", "R-DDI-71240", "R-RNO-71240", "R-DDI-8964208", "R-SCE-8964208", "R-MMU-8964208"], "pathways": ["PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-801:t:homocysteine and cysteine interconversion", "PWY-7901:t:glucosinolate biosynthesis from tyrosine", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-2821:t:glucosinolate biosynthesis from phenylalanine", "PWY-8302:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine degradation", "R-HSA-71240:r:Tryptophan catabolism", "R-SPO-71240:r:Tryptophan catabolism", "R-SPO-8964208:r:Phenylalanine metabolism", "R-HSA-8964539:r:Glutamate and glutamine metabolism", "R-DDI-8964539:r:Glutamate and glutamine metabolism", "R-SPO-8964539:r:Glutamate and glutamine metabolism", "R-RNO-8964208:r:Phenylalanine metabolism", "R-RNO-8964539:r:Glutamate and glutamine metabolism", "R-SCE-71240:r:Tryptophan catabolism", "R-MMU-8964539:r:Glutamate and glutamine metabolism", "R-MMU-71240:r:Tryptophan catabolism", "R-HSA-8964208:r:Phenylalanine metabolism", "R-SCE-8964539:r:Glutamate and glutamine metabolism", "R-DDI-71240:r:Tryptophan catabolism", "R-RNO-71240:r:Tryptophan catabolism", "R-DDI-8964208:r:Phenylalanine metabolism", "R-SCE-8964208:r:Phenylalanine metabolism", "R-MMU-8964208:r:Phenylalanine metabolism"], "type": "Family"}, "IPR051327": {"description": "Multi Antimicrobial Extrusion Protein MepA", "go_ids": [], "go_terms": [], "name": "MATE_MepA_subfamily", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051328": {"description": "Type VII Secretion & ABC Transporter Permease", "go_ids": [], "go_terms": [], "name": "T7SS_ABC-Transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051329": {"description": "Nitrite and Sulfite Reductase 4Fe-4S Domain-Containing Protein", "go_ids": [], "go_terms": [], "name": "NIR_SIR_4Fe-4S", "pathway_ids": ["R-MTU-936721"], "pathways": ["R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Family"}, "IPR051330": {"description": "Phosphatase regulators and Met sulfoxide reductases", "go_ids": [], "go_terms": [], "name": "Phosphatase_reg/MetRdx", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051331": {"description": "Chorismate mutase-related enzymes", "go_ids": [], "go_terms": [], "name": "Chorismate_mutase-related", "pathway_ids": ["PWY-7626", "PWY-3462", "PWY-6120", "PWY-3461", "PWY-6627"], "pathways": ["PWY-7626:t:bacilysin biosynthesis", "PWY-3462:t:L-phenylalanine biosynthesis II", "PWY-6120:t:L-tyrosine biosynthesis III", "PWY-3461:t:L-tyrosine biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis"], "type": "Family"}, "IPR051332": {"description": "Fosfomycin Resistance Enzymes", "go_ids": [], "go_terms": [], "name": "Fosfomycin_Res_Enzymes", "pathway_ids": ["PWY-4681", "PWY-8382", "PWY-8389", "PWY-7529", "PWY-8243", "PWY-7998", "PWY-6262", "PWY-8442", "PWY-5802", "PWY-7493", "PWY-5815", "PWY-5817", "PWY-8084", "PWY-7540", "PWY-7520", "PWY-7555", "PWY-8388", "PWY-6659", "PWY-7407", "PWY-7599", "PWY-7405", "PWY-7719", "PWY-6681", "PWY-8461", "PWY-7906", "PWY-7543", "PWY-8253", "PWY-7372", "PWY-8083", "PWY-5979", "PWY-5893", "PWY-7603", "PWY-6403", "PWY-7532", "PWY-6936", "PWY-7605", "PWY-5816", "PWY-7708", "PWY-7659", "PWY-4502", "PWY-7572", "PWY-8080"], "pathways": ["PWY-4681:t:kievitone biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-8389:t:penigequinolone biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-7998:t:menaquinol-4 biosynthesis II", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-8442:t:hyperxanthone E biosynthesis", "PWY-5802:t:alizarin biosynthesis", "PWY-7493:t:paxilline and diprenylpaxilline biosynthesis", "PWY-5815:t:rubber biosynthesis", "PWY-5817:t:dodecaprenyl diphosphate biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7540:t:aflatrem biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-8388:t:aspoquinolone biosynthesis", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-6681:t:neurosporaxanthin biosynthesis", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7906:t:rhizobitoxine biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-8083:t:domoic acid biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-5893:t:tridecaprenyl diphosphate biosynthesis", "PWY-7603:t:stephacidin A biosynthesis", "PWY-6403:t:carrageenan biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-7605:t:roquefortine C biosynthesis", "PWY-5816:t:all trans undecaprenyl diphosphate biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-4502:t:wighteone and luteone biosynthesis", "PWY-7572:t:lolitrem B biosynthesis", "PWY-8080:t:kainate biosynthesis"], "type": "Family"}, "IPR051333": {"description": "CLIP domain-containing serine protease", "go_ids": [], "go_terms": [], "name": "CLIP_Serine_Protease", "pathway_ids": ["PWY-7884", "R-DME-209442"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'"], "type": "Family"}, "IPR051335": {"description": "Alanyl-tRNA Editing Enzymes", "go_ids": [], "go_terms": [], "name": "Alanyl-tRNA_Editing_Enzymes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051336": {"description": "Rho GTPase-activating Guanine Nucleotide Exchange Factors", "go_ids": [], "go_terms": [], "name": "RhoGEF_Guanine_NuclExch_SF", "pathway_ids": ["R-RNO-9013026", "R-MMU-416476", "R-HSA-9013409", "R-MMU-9013106", "R-RNO-9013409", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-RNO-5687128", "R-HSA-9013106", "R-HSA-416476", "R-HSA-418885", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-DRE-9013404", "R-HSA-3928662", "R-HSA-9013423", "R-DRE-9013423", "R-RNO-416482", "R-HSA-9013148", "R-RNO-3928662", "R-DRE-9013149", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-9013106", "R-RNO-416476", "R-RNO-193648", "R-HSA-193648", "R-DRE-9013408", "R-DRE-9013409", "R-DRE-416482", "R-HSA-416482", "R-RNO-9013148", "R-RNO-418885", "R-RNO-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-HSA-193634", "R-HSA-8980692", "R-HSA-5687128", "R-MMU-9013026", "R-MMU-416482", "R-MMU-3928662", "R-MMU-193648", "R-HSA-9013026", 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["PWY-8344:t:ansamitocin P biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-5:t:canavanine biosynthesis"], "type": "Family"}, "IPR051339": {"description": "DnaJ homolog subfamily B", "go_ids": [], "go_terms": [], "name": "DnaJ_subfamily_B", "pathway_ids": ["R-SCE-3371453", "R-SCE-3371497", "R-SPO-3371453", "R-SPO-3371568", "R-BTA-3371453", "R-BTA-3371568", "R-SPO-3371571", "R-BTA-5687128", "R-BTA-3371571", "R-MMU-3371571", "R-HSA-3371497", "R-SCE-3371568", "R-SPO-3371497", "R-HSA-3371453", "R-HSA-5687128", "R-MMU-3371568", "R-HSA-3371571", "R-BTA-3371497", "R-MMU-5687128", "R-HSA-3371568", "R-SCE-3371571", "R-MMU-3371497", "R-MMU-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", 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"R-MMU-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Family"}, "IPR051340": {"description": "Haloalkane Dehalogenase Enzyme", "go_ids": [], "go_terms": [], "name": "Haloalkane_dehalogenase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051341": {"description": "Zyg-11-related ubiquitin ligase adapter protein", "go_ids": [], "go_terms": [], "name": "Zyg-11_UBL_adapter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051342": {"description": "PDZ domain-containing scaffold protein", "go_ids": [], "go_terms": [], "name": "PDZ_scaffold", "pathway_ids": ["R-DME-983168", "R-HSA-9705677", "R-HSA-983168", "R-HSA-420029", "R-MMU-983168"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9705677:r:SARS-CoV-2 targets PDZ proteins in cell-cell junction", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-420029:r:Tight junction interactions", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR051343": {"description": "G-type lectin S-receptor-like kinases and EP1-like glycoproteins", "go_ids": [], "go_terms": [], "name": "G-type_lectin_kinases/EP1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051344": {"description": "Virginiamycin B lyase", "go_ids": [], "go_terms": [], "name": "Vgb", "pathway_ids": ["PWY-5397"], "pathways": ["PWY-5397:t:crocetin biosynthesis"], "type": "Family"}, "IPR051345": {"description": "Importin beta-like nuclear transport receptors", "go_ids": [], "go_terms": [], "name": "Importin_beta-like_NTR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051346": {"description": "OTU Domain-Containing Deubiquitinase", "go_ids": [], "go_terms": [], "name": "OTU_Deubiquitinase", "pathway_ids": ["R-MMU-5357786", "R-BTA-5689896", "R-DRE-195253", "R-HSA-168638", "R-BTA-195253", "R-HSA-5689896", "R-HSA-936440", "R-MMU-5357956", "R-MMU-5689896", "R-HSA-5357786", "R-DME-195253", "R-MMU-195253", "R-DME-5689896", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357905", "R-XTR-195253", "R-DRE-5689896", "R-MMU-936440", "R-MMU-168638", "R-XTR-5689896", "R-HSA-195253"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-5689896:r:Ovarian tumor domain proteases", "R-DRE-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5689896:r:Ovarian tumor domain proteases", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-DME-5689896:r:Ovarian tumor domain proteases", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-XTR-195253:r:Degradation of beta-catenin by the destruction complex", "R-DRE-5689896:r:Ovarian tumor domain proteases", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-XTR-5689896:r:Ovarian tumor domain proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex"], "type": "Family"}, "IPR051348": {"description": "U-box domain-containing ubiquitin ligases", "go_ids": [], "go_terms": [], "name": "U-box_ubiquitin_ligases", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR051349": {"description": "Hydrogenase complex-associated protein", "go_ids": [], "go_terms": [], "name": "Hydrogenase_assoc-protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051350": {"description": "WD repeat-containing signal transduction regulator", "go_ids": [], "go_terms": [], "name": "WD_repeat-ST_regulator", "pathway_ids": ["R-DRE-9861718", "R-HSA-9861718", "R-RNO-9861718", "R-DME-9861718", "R-MMU-9861718"], "pathways": ["R-DRE-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DME-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism"], "type": "Family"}, "IPR051351": {"description": "Ascorbate-specific PTS system EIIA component", "go_ids": [], "go_terms": [], "name": "Ascorbate-PTS_EIIA_comp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051353": {"description": "Tobamovirus Resistance UPF0261", "go_ids": [], "go_terms": [], "name": "Tobamovirus_resist_UPF0261", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051354": {"description": "Transposase 27 family, IS1 element", "go_ids": [], "go_terms": [], "name": "Transposase_27_IS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051355": {"description": "Notch and Slit guidance protein", "go_ids": [], "go_terms": [], "name": "Notch/Slit_guidance", "pathway_ids": ["R-HSA-8941856", "R-HSA-9604323", "R-HSA-2122948", "R-RNO-9017802", "R-HSA-9010553", "R-MMU-2122947", "R-MMU-2122948", "R-MMU-9010553", "R-HSA-9818749", "R-HSA-9824272", "R-DME-9010553", "R-HSA-1912408", "R-HSA-9017802", "R-RNO-350054", "R-CEL-9010553", "R-MMU-1912420", "R-HSA-5083630", "R-HSA-2979096", "R-HSA-9818030", "R-HSA-9013700", "R-MMU-9013507", "R-RNO-1912420", "R-DME-428890", "R-HSA-2691232", "R-HSA-9013507", "R-HSA-2122947", "R-MMU-9013700", "R-DME-376176", "R-HSA-1912420", "R-HSA-9013508", "R-HSA-8985801", "R-HSA-210744", "R-HSA-428542", "R-HSA-376176", "R-HSA-2894862", "R-MMU-428890", "R-RNO-9013507", "R-MMU-8985586", "R-HSA-373752", "R-MMU-9017802", "R-HSA-350054", "R-MMU-9604323", "R-HSA-9830674", "R-HSA-8985586", "R-HSA-428543", "R-HSA-9013695", "R-MMU-376176", "R-HSA-2644607", "R-HSA-2660826", "R-MMU-350054", "R-MMU-8941856", "R-HSA-428540", "R-HSA-9793380", "R-HSA-2644606", "R-HSA-428890", "R-HSA-2197563", "R-CEL-376176", "R-HSA-1912399"], "pathways": ["R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-RNO-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-9824272:r:Somitogenesis", "R-DME-9010553:r:Regulation of expression of SLITs and ROBOs", 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the Nucleus", "R-DME-376176:r:Signaling by ROBO receptors", "R-HSA-1912420:r:Pre-NOTCH Processing in Golgi", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-8985801:r:Regulation of cortical dendrite branching", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-376176:r:Signaling by ROBO receptors", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-MMU-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-373752:r:Netrin-1 signaling", "R-MMU-9017802:r:Noncanonical activation of NOTCH3", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-MMU-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8985586:r:SLIT2:ROBO1 increases RHOA activity", "R-HSA-428543:r:Inactivation of CDC42 and RAC1", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-MMU-376176:r:Signaling by ROBO receptors", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-428540:r:Activation of RAC1", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-CEL-376176:r:Signaling by ROBO receptors", "R-HSA-1912399:r:Pre-NOTCH Processing in the Endoplasmic Reticulum"], "type": "Family"}, "IPR051356": {"description": "SOX/SOX-like transcription factors", "go_ids": [], 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"PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-DRE-9854311", "R-HSA-9854311"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-DRE-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle"], "type": "Family"}, "IPR051420": {"description": "Ser/Thr Protein Kinases with Diverse Regulatory Roles", "go_ids": [], "go_terms": [], "name": "Ser_Thr_Kinases_DiverseReg", "pathway_ids": ["R-MMU-8857538", "R-HSA-8857538"], "pathways": ["R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Family"}, "IPR051421": {"description": "RNA Processing and DNA Damage Response Regulator", "go_ids": [], "go_terms": [], "name": "RNA_Proc_DNA_Dmg_Regulator", "pathway_ids": ["R-DME-9770562", "R-SPO-9770562", "R-HSA-72163", "R-DRE-72163", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-72163", "R-DME-72163", "R-RNO-72163", "R-HSA-9918481"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR051422": {"description": "AlkB Family tRNA Methyltransferase/Dioxygenase", "go_ids": [], "go_terms": [], "name": "AlkB_tRNA_MeTrf/Diox", "pathway_ids": ["PWY-6829", "PWY-7888", "R-HSA-6782315"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR051423": {"description": "CD225/Dispanin domain-containing protein", "go_ids": [], "go_terms": [], "name": "CD225/Dispanin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051424": {"description": "Transketolase-like", "go_ids": [], "go_terms": [], "name": "Transketolase-like", "pathway_ids": ["PWY-1861", "PWY-6901", "PWY-8178", "PWY-5723", "R-RNO-163754", "R-MMU-71336", "R-HSA-71336", "R-RNO-71336", "R-HSA-163754", "R-HSA-9818028", "R-MMU-163754"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-5723:t:Rubisco shunt", "R-RNO-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-MMU-71336:r:Pentose phosphate pathway", "R-HSA-71336:r:Pentose phosphate pathway", "R-RNO-71336:r:Pentose phosphate pathway", "R-HSA-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-MMU-163754:r:Insulin effects increased synthesis of Xylulose-5-Phosphate"], "type": "Family"}, "IPR051425": {"description": "Formin Homology", "go_ids": [], "go_terms": [], "name": "Formin_Homology", "pathway_ids": ["R-HSA-8980692", "R-MMU-9013106", "R-MMU-9013026", "R-MMU-8980692", "R-HSA-9013148", "R-MMU-4086400", "R-HSA-4086400", "R-HSA-9013026", "R-HSA-5663220", "R-HSA-9013106", "R-MMU-5663220"], "pathways": ["R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-4086400:r:PCP/CE pathway", "R-HSA-4086400:r:PCP/CE pathway", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR051426": {"description": "Peflin/Sorcin Calcium-Binding", "go_ids": [], "go_terms": [], "name": "Peflin/Sorcin_CaBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051427": {"description": "Nectin and Nectin-like", "go_ids": [], "go_terms": [], "name": "Nectin/Nectin-like", "pathway_ids": ["R-DME-420597", "R-HSA-418990", "R-MMU-420597", "R-DRE-418990", "R-DRE-420597", "R-HSA-420597", "R-DME-418990", "R-MMU-418990"], "pathways": ["R-DME-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-418990:r:Adherens junctions interactions", "R-MMU-420597:r:Nectin/Necl trans heterodimerization", "R-DRE-418990:r:Adherens junctions interactions", "R-DRE-420597:r:Nectin/Necl trans heterodimerization", "R-HSA-420597:r:Nectin/Necl trans heterodimerization", "R-DME-418990:r:Adherens junctions interactions", "R-MMU-418990:r:Adherens junctions interactions"], "type": "Family"}, "IPR051428": {"description": "Sphingolipid Activators and Surfactant Proteins", "go_ids": [], "go_terms": [], "name": "Sphingo_Act-Surfact_Prot", "pathway_ids": ["R-RNO-6798695", "R-HSA-6798695", "R-RNO-9840310", "R-HSA-5688031", "R-MMU-9840310", "R-HSA-375276", "R-HSA-9840310", "R-RNO-5683826", "R-MMU-375276", "R-MMU-418594", "R-RNO-114608", "R-RNO-418594", "R-HSA-114608", "R-HSA-418594", "R-HSA-5688890", "R-HSA-5683826", "R-RNO-375276", "R-MMU-6798695", "R-BTA-5683826", "R-MMU-5683826", "R-HSA-5688849", "R-MMU-114608"], "pathways": ["R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-5688031:r:Defective pro-SFTPB causes SMDP1 and RDS", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-RNO-5683826:r:Surfactant metabolism", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-RNO-114608:r:Platelet degranulation", "R-RNO-418594:r:G alpha (i) signalling events", "R-HSA-114608:r:Platelet degranulation", "R-HSA-418594:r:G alpha (i) signalling events", "R-HSA-5688890:r:Defective CSF2RA causes SMDP4", "R-HSA-5683826:r:Surfactant metabolism", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-5683826:r:Surfactant metabolism", "R-MMU-5683826:r:Surfactant metabolism", "R-HSA-5688849:r:Defective CSF2RB causes SMDP5", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR051429": {"description": "Encapsulin nanocompartment", "go_ids": [], "go_terms": [], "name": "Encapsulin_nc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051431": {"description": "Transcription initiation factor TFIID subunit 9/TAF9", "go_ids": [], "go_terms": [], "name": "TFIID_subunit_9/TAF9", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-HSA-6807505", "R-BTA-73776", "R-RNO-6807505", "R-SCE-75953", "R-RNO-674695", "R-DME-76042", "R-RNO-73779", "R-MMU-75953", "R-HSA-5689880", "R-BTA-76042", "R-SPO-6807505", "R-MMU-6804756", "R-DME-73779", "R-RNO-73776", "R-HSA-167162", "R-MMU-5689880", "R-SCE-6807505", "R-SPO-76042", "R-DME-73776", "R-HSA-73776", "R-BTA-6804756", "R-HSA-75953", "R-CEL-75953", "R-RNO-6804756", "R-MMU-73776", "R-DME-75953", "R-MMU-73779", "R-CEL-73776", "R-HSA-167172", "R-MMU-76042", "R-SPO-75953", "R-BTA-73779", "R-SCE-73779", "R-CEL-6807505", "R-BTA-75953", "R-DME-674695", "R-RNO-76042", "R-BTA-674695", "R-MMU-674695", "R-MMU-6807505", "R-RNO-5689880", "R-SCE-76042", "R-DME-6804756", "R-CEL-674695", "R-HSA-167161", "R-DME-6807505", "R-HSA-6804756", "R-SCE-674695", "R-SPO-73779", "R-HSA-3214847", "R-HSA-76042", "R-HSA-674695", "R-BTA-6807505", "R-SPO-73776", "R-CEL-76042", "R-RNO-75953", "R-DME-5689880", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-73776:r:RNA Polymerase II 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"R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-BTA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-RNO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73779:r:RNA 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["R-MMU-8875513", "R-RNO-8875513", "R-BTA-8875513", "R-HSA-8875513"], "pathways": ["R-MMU-8875513:r:MET interacts with TNS proteins", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-BTA-8875513:r:MET interacts with TNS proteins", "R-HSA-8875513:r:MET interacts with TNS proteins"], "type": "Family"}, "IPR051485": {"description": "SR-related and CTD-associated factor", "go_ids": [], "go_terms": [], "name": "SR-CTD_assoc_factor", "pathway_ids": ["R-HSA-72163", "R-HSA-9770562", "R-HSA-9918481", "R-MMU-9770562", "R-MMU-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR051486": {"description": "Homocysteine S-methyltransferase", "go_ids": [], "go_terms": [], "name": "Hcy_S-methyltransferase", "pathway_ids": ["PWY-5441"], "pathways": ["PWY-5441:t:S-methyl-L-methionine cycle"], "type": "Family"}, "IPR051487": {"description": "Serine/Threonine Proteases with Immune and Developmental Roles", "go_ids": [], "go_terms": [], "name": "Ser/Thr_Proteases_Immune/Dev", "pathway_ids": ["PWY-7884", "R-DME-209442"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'"], "type": "Family"}, "IPR051488": {"description": "WD repeat-containing striatin", "go_ids": [], "go_terms": [], "name": "WD_repeat_striatin", "pathway_ids": ["R-HSA-9009391", "R-RNO-6811558", "R-HSA-9673766", "R-HSA-9700645", "R-MMU-6811558", "R-RNO-1257604", "R-RNO-9009391", "R-MMU-9009391", "R-HSA-2219530", "R-HSA-1257604", "R-MMU-1257604", "R-HSA-9725370", "R-HSA-6811558"], "pathways": ["R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9673766:r:Signaling by cytosolic PDGFRA and PDGFRB fusion proteins", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "type": "Family"}, "IPR051489": {"description": "Disintegrin and Metalloproteinase Domain-Containing", "go_ids": [], "go_terms": [], "name": "ADAM_Metalloproteinase", "pathway_ids": ["R-HSA-6798695", "R-SSC-6798695", "R-HSA-2122948", "R-HSA-9662834", "R-RNO-1474228", "R-CEL-6798695", "R-HSA-977225", "R-HSA-1251985", "R-BTA-6798695", "R-HSA-75893", "R-SSC-1474228", "R-RNO-193692", "R-MMU-8957275", "R-BTA-8957275", "R-MMU-193692", "R-HSA-2979096", "R-HSA-5362798", "R-HSA-9013700", "R-MMU-9013507", "R-RNO-8957275", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-BTA-381426", "R-HSA-177929", "R-RNO-75893", "R-HSA-9013507", "R-HSA-2691232", "R-HSA-381426", "R-HSA-1442490", "R-MMU-1474228", "R-MMU-75893", "R-HSA-1474228", "R-SSC-381426", "R-SSC-8957275", "R-BTA-1474228", "R-HSA-2894862", "R-RNO-9013507", "R-HSA-982772", "R-RNO-381426", "R-HSA-2660826", "R-HSA-3928665", "R-MMU-6798695", "R-HSA-8957275", "R-HSA-2644606", "R-HSA-193692", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-HSA-2122948:r:Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-9662834:r:CD163 mediating an anti-inflammatory response", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-75893:r:TNF signaling", "R-SSC-1474228:r:Degradation of the extracellular matrix", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-5362798:r:Release of Hh-Np from the secreting cell", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-177929:r:Signaling by EGFR", "R-RNO-75893:r:TNF signaling", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1442490:r:Collagen degradation", "R-MMU-1474228:r:Degradation of the extracellular matrix", "R-MMU-75893:r:TNF signaling", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-SSC-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-SSC-8957275:r:Post-translational protein phosphorylation", "R-BTA-1474228:r:Degradation of the extracellular matrix", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-982772:r:Growth hormone receptor signaling", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-193692:r:Regulated proteolysis of p75NTR", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR051490": {"description": "THEM6/lcsJ thioesterase", "go_ids": [], "go_terms": [], "name": "THEM6_lcsJ_thioesterase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051491": {"description": "Site-specific recombinase/transposase-related", "go_ids": [], "go_terms": [], "name": "Recombinase/Transposase-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051492": {"description": "Dynamin-binding and Rho GEF", "go_ids": [], "go_terms": [], "name": "Dynamin-Rho_GEF", "pathway_ids": ["R-SCE-9013148", "R-SCE-193648", "R-HSA-193648", "R-DRE-9013148", "R-SPO-416482", "R-RNO-416482", "R-MMU-416482", "R-HSA-9013148", "R-MMU-193648", "R-SCE-416482", "R-HSA-416482", "R-RNO-9013148", "R-MMU-9013148", "R-SPO-9013148", "R-RNO-193648"], "pathways": ["R-SCE-9013148:r:CDC42 GTPase cycle", "R-SCE-193648:r:NRAGE signals death through JNK", "R-HSA-193648:r:NRAGE signals death through JNK", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-SPO-416482:r:G alpha (12/13) signalling events", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-SCE-416482:r:G alpha (12/13) signalling events", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-SPO-9013148:r:CDC42 GTPase cycle", "R-RNO-193648:r:NRAGE signals death through JNK"], "type": "Family"}, "IPR051493": {"description": "Chromodomain-helicase-DNA-binding", "go_ids": [], "go_terms": [], "name": "CHD", "pathway_ids": ["PWY-7250", "R-HSA-1989781", "R-MMU-3769402", "R-DRE-3769402", "R-HSA-2151201", "R-HSA-3769402", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-381340", "R-HSA-400206", "R-HSA-9707616", "R-MMU-400206", "R-RNO-3769402", "R-HSA-1368108", "R-HSA-9931509", "R-MMU-9707564", "R-HSA-9818027", "R-HSA-2426168"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-1989781:r:PPARA activates gene expression", "R-MMU-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-DRE-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9707616:r:Heme signaling", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Family"}, "IPR051494": {"description": "BSD domain-containing protein", "go_ids": [], "go_terms": [], "name": "BSD_domain-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051495": {"description": "Epithelial Barrier and Cell Signaling Protein", "go_ids": [], "go_terms": [], "name": "Epithelial_Barrier/Signaling", "pathway_ids": ["R-DME-977068", "R-HSA-5083632", "R-HSA-5083636", "R-RNO-977068", "R-MMU-913709", "R-HSA-977068", "R-HSA-5083625", "R-CEL-913709", "R-MMU-977068", "R-RNO-913709", "R-DME-913709", "R-HSA-5621480", "R-HSA-913709"], "pathways": ["R-DME-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-RNO-977068:r:Termination of O-glycan biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-CEL-913709:r:O-linked glycosylation of mucins", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-RNO-913709:r:O-linked glycosylation of mucins", "R-DME-913709:r:O-linked glycosylation of mucins", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Family"}, "IPR051496": {"description": "H-rev107 Phospholipase/Acyltransferase", "go_ids": [], "go_terms": [], "name": "H-rev107_PLA/AT", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7417", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7409", "PWY-7907", "PWY-6378", "PWY-7577", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-8356", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-8396", "PWY-7452", "PWY-8413", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-8411", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-8357", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8412", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-8400", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7416", "PWY-7727", "PWY-8398", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8399", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-8395", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-8355", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-8053", "PWY-7460", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-8410", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-7783", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-6803", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-8397", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-RNO-1482788", "R-RNO-1482801", "R-HSA-1482922", "R-MMU-1482922", "R-DRE-1482839", "R-HSA-1482839", "R-MMU-1482788", "R-RNO-1482922", "R-MMU-1482801", "R-RNO-1482839", "R-MMU-1482839", "R-HSA-1482801", "R-HSA-1482788"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7417:t:phospholipid remodeling (phosphatidate, yeast)", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7409:t:phospholipid remodeling (phosphatidylethanolamine, yeast)", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-8356:t:maresin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-8396:t:di-homo-gamma-linolenate metabolites biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8413:t:representative whole plasma EPA-derived icosanoids", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-8357:t:protectin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8412:t:representative whole plasma DHA-derived icosanoids", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-8400:t:docosahexaenoate metabolites biosynthesis", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7416:t:phospholipid remodeling (phosphatidylcholine, yeast)", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8398:t:alpha-linolenate metabolites biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8399:t:icosapentaenoate metabolites biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-8395:t:linoleate metabolites biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-8355:t:peptido-conjugates in tissue regeneration biosynthesis", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-7783:t:plasmalogen degradation", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-6803:t:phosphatidylcholine acyl editing", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-RNO-1482788:r:Acyl chain remodelling of PC", "R-RNO-1482801:r:Acyl chain remodelling of PS", "R-HSA-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482922:r:Acyl chain remodelling of PI", "R-DRE-1482839:r:Acyl chain remodelling of PE", "R-HSA-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482788:r:Acyl chain remodelling of PC", "R-RNO-1482922:r:Acyl chain remodelling of PI", "R-MMU-1482801:r:Acyl chain remodelling of PS", "R-RNO-1482839:r:Acyl chain remodelling of PE", "R-MMU-1482839:r:Acyl chain remodelling of PE", "R-HSA-1482801:r:Acyl chain remodelling of PS", "R-HSA-1482788:r:Acyl chain remodelling of PC"], "type": "Family"}, "IPR051497": {"description": "Developmental and Hematopoietic Transcription Factors", "go_ids": [], "go_terms": [], "name": "Dev/Hematopoietic_TF", "pathway_ids": ["R-DME-9933946", "R-MMU-9933946", "R-MMU-9934037", "R-HSA-9725370", "R-HSA-9700645", "R-HSA-9933946", "R-DME-9934037", "R-DME-210671", "R-HSA-9934037"], "pathways": ["R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DME-210671:r:Transcriptional repression by nuclear factors", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "type": "Family"}, "IPR051498": {"description": "Phosducin-like chaperone and apoptosis regulator", "go_ids": [], "go_terms": [], "name": "Phosducin-like_chap/apop_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051499": {"description": "Phosducin-like regulator", "go_ids": [], "go_terms": [], "name": "Phosducin-like_reg", "pathway_ids": ["R-RNO-6814122", "R-HSA-6814122", "R-BTA-6814122", "R-DME-6814122", "R-MMU-6814122"], "pathways": ["R-RNO-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-HSA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-BTA-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-DME-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "R-MMU-6814122:r:Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "type": "Family"}, "IPR051500": {"description": "cTAGE and MIA/OTOR", "go_ids": [], "go_terms": [], "name": "cTAGE_MIA/OTOR", "pathway_ids": ["R-HSA-381426", "R-DME-381426", "R-DME-8957275", "R-MMU-381426", "R-MMU-5694530", "R-HSA-8957275", "R-DME-5694530", "R-MMU-8957275", "R-HSA-5694530"], "pathways": ["R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-5694530:r:Cargo concentration in the ER", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DME-5694530:r:Cargo concentration in the ER", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-5694530:r:Cargo concentration in the ER"], "type": "Family"}, "IPR051501": {"description": "Eukaryotic initiation factor 2B subunits alpha/beta/delta", "go_ids": [], "go_terms": [], "name": "eIF2B_alpha/beta/delta", "pathway_ids": ["R-SCE-72731", "R-HSA-72731", "R-BTA-72731", "R-RNO-72731", "R-CEL-72731", "R-MMU-72731", "R-SPO-72731", "R-DDI-72731"], "pathways": ["R-SCE-72731:r:Recycling of eIF2:GDP", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-BTA-72731:r:Recycling of eIF2:GDP", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-CEL-72731:r:Recycling of eIF2:GDP", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-DDI-72731:r:Recycling of eIF2:GDP"], "type": "Family"}, "IPR051502": {"description": "Receptor-like Defense Trigger", "go_ids": [], "go_terms": [], "name": "RLP_Defense_Trigger", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051503": {"description": "Complement System Regulators and Virion Entry Mediators", "go_ids": [], "go_terms": [], "name": "ComplSys_Reg/VirEntry_Med", "pathway_ids": ["R-MMU-977606", "R-HSA-977606", "R-HSA-140875", "R-MMU-140875"], "pathways": ["R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation"], "type": "Family"}, "IPR051504": {"description": "Plant secondary metabolite acyltransferase", "go_ids": [], "go_terms": [], "name": "Plant_metabolite_acyltrans", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR051505": {"description": "C-type lectin domain-containing protein", "go_ids": [], "go_terms": [], "name": "C-type_lectin_domain", "pathway_ids": ["R-MMU-6798695", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR051506": {"description": "Atos Homolog Transcription Regulators", "go_ids": [], "go_terms": [], "name": "ATOS_Transcription_Regulators", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051507": {"description": "Polycomb group RING finger", "go_ids": [], "go_terms": [], "name": "PcG_RING_finger", "pathway_ids": ["R-MMU-8953750", "R-RNO-8953750", "R-HSA-8939243", "R-DRE-8939243", "R-HSA-8953750", "R-MMU-8939243", "R-BTA-8939243"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-RNO-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DRE-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Family"}, "IPR051508": {"description": "Mitochondrial Carrier Antiporter", "go_ids": [], "go_terms": [], "name": "Mito_Carrier_Antiporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051509": {"description": "GPCR with Orphan and Phoenixin-Mediated Functions", "go_ids": [], "go_terms": [], "name": "GPCR_Orphan/Phoenixin", "pathway_ids": ["R-HSA-418555", "R-MMU-418555"], "pathways": ["R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-418555:r:G alpha (s) signalling events"], "type": "Family"}, "IPR051510": {"description": "Superkiller complex protein 8", "go_ids": [], "go_terms": [], "name": "SKI8", "pathway_ids": ["R-MMU-8866654", "R-BTA-75955", "R-BTA-429958", "R-DDI-429958", "R-XTR-674695", "R-RNO-674695", "R-XTR-429958", "R-HSA-9920588", "R-RNO-75955", "R-DRE-429958", "R-MMU-429958", "R-XTR-112382", "R-BTA-674695", "R-XTR-75955", "R-RNO-8866654", "R-MMU-674695", "R-MMU-75955", "R-MMU-112382", "R-DRE-75955", "R-HSA-8866654", "R-SCE-429958", "R-RNO-429958", "R-DRE-674695", "R-RNO-112382", "R-HSA-75955", "R-BTA-8866654", "R-XTR-8866654", "R-HSA-429958", "R-SCE-983168", "R-HSA-674695", "R-SPO-429958", "R-HSA-112382"], "pathways": ["R-MMU-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-BTA-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DDI-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-RNO-75955:r:RNA Polymerase II Transcription Elongation", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-BTA-674695:r:RNA Polymerase II Pre-transcription Events", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-RNO-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-SCE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-RNO-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-BTA-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-XTR-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-HSA-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Family"}, "IPR051511": {"description": "Mitochondrial Quality Control and Scaffold Kinases", "go_ids": [], "go_terms": [], "name": "MitoQC_Scaffold_Kinases", "pathway_ids": ["R-HSA-9013420", "R-MMU-9013420", "R-DME-5205685", "R-RNO-5205685", "R-HSA-9696270", "R-RNO-9696270", "R-MMU-9013424", "R-HSA-5205685", "R-CEL-5205685", "R-MMU-9696270", "R-MMU-5205685", "R-HSA-9614657", "R-HSA-9013424"], "pathways": ["R-HSA-9013420:r:RHOU GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-9696270:r:RND2 GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-CEL-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-9013424:r:RHOV GTPase cycle"], "type": "Family"}, "IPR051512": {"description": "Inactive Rhomboid", "go_ids": [], "go_terms": [], "name": "Inactive_Rhomboid", "pathway_ids": ["R-HSA-9662834"], "pathways": ["R-HSA-9662834:r:CD163 mediating an anti-inflammatory response"], "type": "Family"}, "IPR051513": {"description": "Tectonin beta-propeller repeat-containing", "go_ids": [], "go_terms": [], "name": "Tectonin_beta-prop", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051514": {"description": "R-spondin domain-containing protein", "go_ids": [], "go_terms": [], "name": "R-spondin", "pathway_ids": ["R-XTR-4641263", "R-HSA-8939256", "R-MMU-4641263", "R-BTA-4641263", "R-HSA-4641263", "R-DRE-4641263"], "pathways": ["R-XTR-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-8939256:r:RUNX1 regulates transcription of genes involved in WNT signaling", "R-MMU-4641263:r:Regulation of FZD by ubiquitination", "R-BTA-4641263:r:Regulation of FZD by ubiquitination", "R-HSA-4641263:r:Regulation of FZD by ubiquitination", "R-DRE-4641263:r:Regulation of FZD by ubiquitination"], "type": "Family"}, "IPR051515": {"description": "Immunity-related GTPase", "go_ids": [], "go_terms": [], "name": "IRG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051516": {"description": "Histone-lysine N-methyltransferase SETDB", "go_ids": [], "go_terms": [], "name": "SETDB_methyltransferase", "pathway_ids": ["R-MMU-3214841", "R-MMU-9843940", "R-DRE-9843940", "R-DRE-3214841", "R-HSA-3214841", "R-HSA-9843970", "R-DME-3214841", "R-DRE-9843970", "R-DME-9843940", "R-HSA-9843940", "R-CEL-3214841"], "pathways": ["R-MMU-3214841:r:PKMTs methylate histone lysines", "R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DME-3214841:r:PKMTs methylate histone lysines", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DME-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-CEL-3214841:r:PKMTs methylate histone lysines"], "type": "Family"}, "IPR051517": {"description": "Interferon-induced transmembrane antiviral protein", "go_ids": [], "go_terms": [], "name": "IFITM_antiviral_protein", "pathway_ids": ["R-HSA-198933", "R-MMU-198933", "R-HSA-909733", "R-RNO-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR051518": {"description": "Plant Sucrose Phosphatase", "go_ids": [], "go_terms": [], "name": "Sucrose_Phosphatase", "pathway_ids": ["PWY-7238", "PWY-7347"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-7347:t:sucrose biosynthesis III"], "type": "Family"}, "IPR051519": {"description": "PDE6D/unc-119 myristoyl-binding", "go_ids": [], "go_terms": [], "name": "PDE6D_unc-119_myristoyl-bd", "pathway_ids": ["R-MMU-5624138", "R-DRE-5624138", "R-HSA-5624138", "R-CEL-5624138"], "pathways": ["R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-CEL-5624138:r:Trafficking of myristoylated proteins to the cilium"], "type": "Family"}, "IPR051520": {"description": "Elbow/Noc Zinc Finger", "go_ids": [], "go_terms": [], "name": "Elbow/Noc_ZnFinger", "pathway_ids": ["R-MMU-212436", "R-HSA-212436"], "pathways": ["R-MMU-212436:r:Generic Transcription Pathway", "R-HSA-212436:r:Generic Transcription Pathway"], "type": "Family"}, "IPR051521": {"description": "tRNA-uridine aminocarboxypropyltransferase 1/YIPF3", "go_ids": [], "go_terms": [], "name": "DTWD1/YIPF3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051522": {"description": "Iron-sulfur cluster assembly LYR protein", "go_ids": [], "go_terms": [], "name": "ISC_assembly_LYR", "pathway_ids": ["R-SPO-9865881", "R-MMU-9865881", "R-HSA-1362409", "R-HSA-9865881", "R-HSA-9854311", "R-BTA-9854311", "R-DDI-9865881", "R-SCE-1362409", "R-PFA-1362409", "R-MMU-1362409", "R-MMU-9854311", "R-BTA-9865881", "R-BTA-1362409", "R-DME-1362409", "R-DDI-1362409", "R-SCE-9865881", "R-SPO-1362409", "R-DME-9865881"], "pathways": ["R-SPO-9865881:r:Complex III assembly", "R-MMU-9865881:r:Complex III assembly", "R-HSA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-HSA-9865881:r:Complex III assembly", "R-HSA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-DDI-9865881:r:Complex III assembly", "R-SCE-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-PFA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-MMU-9854311:r:Maturation of TCA enzymes and regulation of TCA cycle", "R-BTA-9865881:r:Complex III assembly", "R-BTA-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DME-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DDI-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-SCE-9865881:r:Complex III assembly", "R-SPO-1362409:r:Mitochondrial iron-sulfur cluster biogenesis", "R-DME-9865881:r:Complex III assembly"], "type": "Family"}, "IPR051523": {"description": "KISH domain-containing protein", "go_ids": [], "go_terms": [], "name": "KISH_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051524": {"description": "Betaine-homocysteine S-methyltransferase", "go_ids": [], "go_terms": [], "name": "BHMT", "pathway_ids": ["PWY-3661", "R-RNO-1614635", "R-HSA-6798163", "R-RNO-6798163", "R-DRE-1614635", "R-DRE-6798163", "R-MMU-6798163", "R-MMU-1614635", "R-HSA-1614635"], "pathways": ["PWY-3661:t:glycine betaine degradation I", "R-RNO-1614635:r:Sulfur amino acid metabolism", "R-HSA-6798163:r:Choline catabolism", "R-RNO-6798163:r:Choline catabolism", "R-DRE-1614635:r:Sulfur amino acid metabolism", "R-DRE-6798163:r:Choline catabolism", "R-MMU-6798163:r:Choline catabolism", "R-MMU-1614635:r:Sulfur amino acid metabolism", "R-HSA-1614635:r:Sulfur amino acid metabolism"], "type": "Family"}, "IPR051525": {"description": "DVL/RTFL regulatory polypeptides", "go_ids": [], "go_terms": [], "name": "DVL_RTFL_regulatory", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051526": {"description": "Secreted beta-glucosidase SUN", "go_ids": [], "go_terms": [], "name": "Beta-Glucosidase_SUN", "pathway_ids": ["PWY-7529", "PWY-6848", "PWY-7134", "PWY-8435", "PWY-1921", "PWY-7133", "PWY-6784", "PWY-8436", "PWY-7091", "PWY-7074", "PWY-6527", "PWY-6717", "PWY-7647", "PWY-6972", "PWY-8366", "PWY-5976", "PWY-6821", "PWY-6735", "PWY-6906", "PWY-6855", "PWY-7491", "PWY-7057", "PWY-842", "PWY-862", "PWY-6737", "PWY-7445", "PWY-5821", "PWY-6749", "PWY-7056", "PWY-7256"], "pathways": ["PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6848:t:rutin degradation", "PWY-7134:t:rutin degradation (plants)", "PWY-8435:t:yeast mannan degradation", "PWY-1921:t:indole-3-acetate activation II", "PWY-7133:t:quercetin glucoside degradation (Allium)", "PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)", "PWY-8436:t:mammalian high-mannose N-glycan degradation", "PWY-7091:t:linustatin bioactivation", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-6527:t:stachyose degradation", "PWY-6717:t:(1,4)-beta-D-xylan degradation", "PWY-7647:t:ulvan degradation", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8366:t:septacidin biosynthesis", "PWY-5976:t:dhurrin degradation", "PWY-6821:t:kappa-carrageenan degradation", "PWY-6735:t:starch degradation IV", "PWY-6906:t:chitin derivatives degradation", "PWY-6855:t:chitin degradation I (archaea)", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7057:t:cichoriin interconversion", "PWY-842:t:starch degradation I", "PWY-862:t:fructan degradation", "PWY-6737:t:starch degradation V", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-5821:t:dalcochinin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7056:t:daphnin interconversion", "PWY-7256:t:cyanidin diglucoside biosynthesis (acyl-glucose dependent)"], "type": "Family"}, "IPR051527": {"description": "Killer cell lectin-like receptor subfamily B", "go_ids": [], "go_terms": [], "name": "KLR_subfamily_B", "pathway_ids": ["R-RNO-198933", "R-HSA-198933", "R-MMU-198933"], "pathways": ["R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR051528": {"description": "Keratin-associated protein type 19", "go_ids": [], "go_terms": [], "name": "KRTAP_type_19", "pathway_ids": ["R-MMU-6805567", "R-HSA-6805567"], "pathways": ["R-MMU-6805567:r:Keratinization", "R-HSA-6805567:r:Keratinization"], "type": "Family"}, "IPR051529": {"description": "Seed Storage Prolamin", "go_ids": [], "go_terms": [], "name": "Seed_Storage_Prolamin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051530": {"description": "Metabotropic Glutamate/GABA-B Receptor-like", "go_ids": [], "go_terms": [], "name": "mGluR/GABA-B-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051531": {"description": "N-acetyltransferase", "go_ids": [], "go_terms": [], "name": "N-acetyltransferase", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR051532": {"description": "Diverse Ester Hydrolysis Enzymes", "go_ids": [], "go_terms": [], "name": "Ester_Hydrolysis_Enzymes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051533": {"description": "O-antigen ligase-like", "go_ids": [], "go_terms": [], "name": "WaaL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051534": {"description": "CBASS antivirus and pafABC operon-associated protein", "go_ids": [], "go_terms": [], "name": "CBASS_pafABC_assoc_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051535": {"description": "Bacterial siderophore ABC transporter ATP-binding", "go_ids": [], "go_terms": [], "name": "Siderophore_ABC-ATPase", "pathway_ids": ["R-HSA-9638334", "R-HSA-9638482"], "pathways": ["R-HSA-9638334:r:Iron assimilation using enterobactin", "R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR051536": {"description": "Uracil-DNA glycosylase family, Type-4/5", "go_ids": [], "go_terms": [], "name": "UDG_Type-4/5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051537": {"description": "DNA Adenine N(4)/N(6)-Methyltransferase", "go_ids": [], "go_terms": [], "name": "DNA_Adenine_Mtase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051538": {"description": "Acyl-CoA Synthetase/Transferase", "go_ids": [], "go_terms": [], "name": "Acyl-CoA_Synth/Transferase", "pathway_ids": ["PWY-5483", "PWY-5535", "PWY-8305"], "pathways": ["PWY-5483:t:pyruvate fermentation to acetate III", "PWY-5535:t:acetate and ATP formation from acetyl-CoA II", "PWY-8305:t:methoxylated aromatic compound degradation II"], "type": "Family"}, "IPR051539": {"description": "Type IV secretion system coupling protein TraD/TraG/VirD4-like", "go_ids": [], "go_terms": [], "name": "T4SS-coupling_proteins", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051540": {"description": "S-2-haloalkanoic acid dehalogenase", "go_ids": [], "go_terms": [], "name": "S-2-haloacid_dehalogenase", "pathway_ids": ["PWY-7425"], "pathways": ["PWY-7425:t:2-chloroacrylate degradation I"], "type": "Family"}, "IPR051541": {"description": "PTS System Sugar Transport and Nitrogen Regulation", "go_ids": [], "go_terms": [], "name": "PTS_SugarTrans_NitroReg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051542": {"description": "Hydrogenase-associated cytochrome", "go_ids": [], "go_terms": [], "name": "Hydrogenase_cytochrome", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051543": {"description": "Serine Peptidase S9A Subfamily", "go_ids": [], "go_terms": [], "name": "Serine_Peptidase_S9A", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR051544": {"description": "Two-partner secretion system outer membrane transporter", "go_ids": [], "go_terms": [], "name": "TPS_OM_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051545": {"description": "NAD(P)H dehydrogenase (quinone)", "go_ids": [], "go_terms": [], "name": "NAD(P)H_dehydrogenase_qn", "pathway_ids": ["R-RNO-211945", "R-HSA-350562", "R-HSA-211945", "R-RNO-350562", "R-MMU-211945", "R-HSA-9818027", "R-MMU-350562"], "pathways": ["R-RNO-211945:r:Phase I - Functionalization of compounds", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-211945:r:Phase I - Functionalization of compounds", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-211945:r:Phase I - Functionalization of compounds", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)"], "type": "Family"}, "IPR051546": {"description": "Class-II Aspartate Ammonia-Lyase", "go_ids": [], "go_terms": [], "name": "Aspartate_Ammonia-Lyase", "pathway_ids": ["PWY-8294", "PWY-8419", "PWY-8291"], "pathways": ["PWY-8294:t:L-aspartate degradation III (anaerobic)", "PWY-8419:t:L-canavanine degradation II", "PWY-8291:t:L-aspartate degradation II (aerobic)"], "type": "Family"}, "IPR051547": {"description": "Tyrosyl-DNA phosphodiesterase 2-like", "go_ids": [], "go_terms": [], "name": "TDP2-like", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978", "R-BTA-5693571", "R-DRE-5693571", "R-HSA-5693571", "R-RNO-5693571", "R-MMU-5693571"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Family"}, "IPR051548": {"description": "Glutaredoxin-like Electron Transport", "go_ids": [], "go_terms": [], "name": "Grx-like_ET", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051549": {"description": "Phosphoenolpyruvate Utilizing Enzyme", "go_ids": [], "go_terms": [], "name": "PEP_Utilizing_Enz", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051550": {"description": "SCF Complex Subunits and Alginate Epimerases", "go_ids": [], "go_terms": [], "name": "SCF-Subunits/Alg-Epimerases", "pathway_ids": ["R-MMU-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-CEL-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-8951664:r:Neddylation"], "type": "Family"}, "IPR051551": {"description": "Bacterial autotransporter adhesion", "go_ids": [], "go_terms": [], "name": "Autotransporter_adhesion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051552": {"description": "Hexose Phosphate Transport Regulator", "go_ids": [], "go_terms": [], "name": "HptR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051553": {"description": "Ran GTPase-activating", "go_ids": [], "go_terms": [], "name": "Ran_GTPase-activating", "pathway_ids": ["R-SCE-9615933", "R-DDI-9833482", "R-DDI-936440", "R-SPO-9615933", "R-CEL-9833482", "R-CEL-983168", "R-CEL-9615933", "R-MMU-9615933", "R-DME-9615933", "R-DDI-983168", "R-HSA-9615933", "R-CEL-9909505", "R-DDI-9909505", "R-CEL-1169408", "R-CEL-936440", "R-HSA-165054", "R-HSA-180746", "R-SCE-983168", "R-DDI-1169408"], "pathways": ["R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DDI-9833482:r:PKR-mediated signaling", "R-DDI-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-9833482:r:PKR-mediated signaling", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-DDI-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-CEL-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-180746:r:Nuclear import of Rev protein", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-1169408:r:ISG15 antiviral mechanism"], "type": "Family"}, "IPR051554": {"description": "Acetyltransferase Eis", "go_ids": [], "go_terms": [], "name": "Acetyltransferase_Eis", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-HSA-9636569"], "pathways": ["PWY-7045:t:mithramycin 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dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-9636569:r:Suppression of autophagy"], "type": "Family"}, "IPR051555": {"description": "Formate Dehydrogenase Electron Transfer Unit", "go_ids": [], "go_terms": [], "name": "FDH_Electron_Transfer_Unit", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051556": {"description": "N-terminal and lysine N-acetyltransferase", "go_ids": [], "go_terms": [], "name": "N-term/lysine_N-AcTrnsfr", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-7800", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-7800:t:Ac/N-end rule pathway", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR051557": {"description": "NipSnap domain-containing protein", "go_ids": [], "go_terms": [], "name": "NipSnap_domain", "pathway_ids": ["R-CEL-9013407", "R-HSA-9013409", "R-MMU-9013407", "R-DRE-9013407", "R-HSA-9013407", "R-DME-9013407"], "pathways": ["R-CEL-9013407:r:RHOH GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-DRE-9013407:r:RHOH GTPase cycle", "R-HSA-9013407:r:RHOH GTPase cycle", "R-DME-9013407:r:RHOH GTPase cycle"], "type": "Family"}, "IPR051558": {"description": "Metallophosphoesterase Purple Acid Phosphatase", "go_ids": [], "go_terms": [], "name": "Metallophosphoesterase_PAP", "pathway_ids": ["PWY-6348", "R-RNO-196843", "R-PFA-196843", "R-HSA-196843", "R-MMU-196843"], "pathways": ["PWY-6348:t:phosphate acquisition", "R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-PFA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism"], "type": "Family"}, "IPR051559": {"description": "Hypoxia-inducible factor prolyl hydroxylases", "go_ids": [], "go_terms": [], "name": "HIF_prolyl_hydroxylases", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-RNO-1234176", "R-CEL-1234176", "R-MMU-1234176", "R-HSA-1234176"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "type": "Family"}, "IPR051560": {"description": "MAM domain-containing protein", "go_ids": [], "go_terms": [], "name": "MAM_domain-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051561": {"description": "FRAS1-related extracellular matrix", "go_ids": [], "go_terms": [], "name": "FRAS1_ECM", "pathway_ids": ["R-HSA-2024101", "R-RNO-2022923", "R-MMU-2022870", "R-HSA-9725554", "R-HSA-2022870", "R-HSA-3560783", "R-HSA-3595172", "R-HSA-1971475", "R-HSA-3560801", "R-RNO-1971475", "R-HSA-2022923", "R-RNO-2024101", "R-HSA-4420332", "R-HSA-3595177", "R-MMU-2024101", "R-MMU-1971475", "R-MMU-2022923", "R-RNO-2022870", "R-HSA-3595174"], "pathways": ["R-HSA-2024101:r:CS/DS degradation", "R-RNO-2022923:r:DS-GAG biosynthesis", "R-MMU-2022870:r:CS-GAG biosynthesis", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-2022870:r:CS-GAG biosynthesis", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-3595172:r:Defective CHST3 causes SEDCJD", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-RNO-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis", "R-RNO-2024101:r:CS/DS degradation", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-3595177:r:Defective CHSY1 causes TPBS", "R-MMU-2024101:r:CS/DS degradation", "R-MMU-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-RNO-2022870:r:CS-GAG biosynthesis", "R-HSA-3595174:r:Defective CHST14 causes EDS, musculocontractural type"], "type": "Family"}, "IPR051562": {"description": "Ascorbate-specific PTS system EIIC component", "go_ids": [], "go_terms": [], "name": "Ascorbate-PTS_EIIC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051563": {"description": "Glycosyl Hydrolase Family 51", "go_ids": [], "go_terms": [], "name": "Glycosyl_Hydrolase_51", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051564": {"description": "Leucine-rich repeat receptor-like kinase", "go_ids": [], "go_terms": [], "name": "LRR_receptor-like_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051565": {"description": "Sal C2H2-type zinc-finger", "go_ids": [], "go_terms": [], "name": "Sal_C2H2-zinc-finger", "pathway_ids": ["R-HSA-9830674", "R-HSA-452723", "R-HSA-2892247", "R-CEL-8943724", "R-DME-8943724", "R-HSA-8943724", "R-MMU-8943724"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-CEL-8943724:r:Regulation of PTEN gene transcription", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-MMU-8943724:r:Regulation of PTEN gene transcription"], "type": "Family"}, "IPR051566": {"description": "Connector enhancer of kinase suppressor of Ras", "go_ids": [], "go_terms": [], "name": "CNKSR", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-9649948", "R-HSA-6802952", "R-HSA-6802946", "R-RNO-5674135", "R-CEL-5674135", "R-HSA-6802955", "R-HSA-9656223"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Family"}, "IPR051567": {"description": "Unconventional Myosin ATPase", "go_ids": [], "go_terms": [], "name": "Unconventional_Myosin_ATPase", "pathway_ids": ["R-MMU-2453902", "R-CEL-2453902", "R-HSA-9662360", "R-DME-2453902", "R-HSA-9662361", "R-HSA-2453902"], "pathways": ["R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-CEL-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Family"}, "IPR051568": {"description": "LZTR1/Attractin", "go_ids": [], "go_terms": [], "name": "LZTR1/Attractin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051570": {"description": "TBC1 domain family involved in cilium biogenesis", "go_ids": [], "go_terms": [], "name": "TBC1_cilium_biogenesis", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-DDI-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR051571": {"description": "Nuclear receptor corepressor", "go_ids": [], "go_terms": [], "name": "N-CoR_corepressor", "pathway_ids": ["R-MMU-2173795", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-9022692", "R-HSA-1251985", "R-CEL-383280", "R-HSA-9841922", "R-MMU-383280", "R-HSA-2173795", "R-HSA-9707564", "R-HSA-9933387", "R-MMU-9841922", "R-MMU-400206", "R-HSA-9029569", "R-MMU-9029569", "R-HSA-2122947", "R-HSA-9931509", "R-HSA-5617472", "R-MMU-9623433", "R-HSA-9022537", "R-HSA-381340", "R-HSA-2894862", "R-HSA-9707616", "R-HSA-3214815", "R-HSA-9609690", "R-HSA-350054", "R-HSA-383280", "R-MMU-381340", "R-MMU-350054", "R-HSA-400206", "R-HSA-2644606", "R-HSA-3899300", "R-HSA-9623433", "R-MMU-9707564"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9022692:r:Regulation of MECP2 expression and activity", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-CEL-383280:r:Nuclear Receptor transcription pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-MMU-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-HSA-9022537:r:Loss of MECP2 binding ability to the NCoR/SMRT complex", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-9707616:r:Heme signaling", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-9623433:r:NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Family"}, "IPR051572": {"description": "Vacuolar Transporter Chaperone Complex Subunit", "go_ids": [], "go_terms": [], "name": "VTC_Complex_Subunit", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051573": {"description": "Ankyrin repeat and SOCS box protein-like", "go_ids": [], "go_terms": [], "name": "Ankyrin-SOCS_box_domain", "pathway_ids": ["R-BTA-983168", "R-MMU-8951664", "R-BTA-8951664", "R-HSA-8951664", "R-MMU-983168", "R-DRE-8951664", "R-HSA-983168", "R-DRE-983168"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR051574": {"description": "Zinc finger E-box-binding homeobox", "go_ids": [], "go_terms": [], "name": "ZnF_E-box_Homeobox", "pathway_ids": ["R-DME-9762293", "R-RNO-9764725", "R-MMU-9762293", "R-HSA-9832991", "R-CEL-9764725", "R-HSA-9926550", "R-DME-9764725", "R-CEL-9762293", "R-HSA-9764725", "R-HSA-6785807", "R-HSA-9764790", "R-MMU-9764725", "R-HSA-9762293", "R-HSA-9823739"], "pathways": ["R-DME-9762293:r:Regulation of CDH11 gene transcription", "R-RNO-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-9762293:r:Regulation of CDH11 gene transcription", "R-HSA-9832991:r:Formation of the posterior neural plate", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-9762293:r:Regulation of CDH11 gene transcription", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-9762293:r:Regulation of CDH11 gene transcription", "R-HSA-9823739:r:Formation of the anterior neural plate"], "type": "Family"}, "IPR051575": {"description": "Myb-like DNA-binding", "go_ids": [], "go_terms": [], "name": "Myb-like_DNA-bd", "pathway_ids": ["R-HSA-76071", "R-MMU-76071", "R-CEL-6807505", "R-HSA-749476", "R-HSA-6807505", "R-MMU-6807505", "R-DDI-6807505"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-CEL-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Family"}, "IPR051576": {"description": "PX Domain-Containing Rho GAP", "go_ids": [], "go_terms": [], "name": "PX-Rho_GAP", "pathway_ids": ["R-HSA-9013405", "R-HSA-9013409", "R-MMU-9035034", "R-DME-9013149", "R-HSA-9013420", "R-DME-8980692", "R-MMU-9013106", "R-MMU-8980692", "R-MMU-9013408", "R-MMU-9013409", "R-MMU-9013148", "R-HSA-9013106", "R-MMU-9013404", "R-HSA-9013404", "R-HSA-9013423", "R-MMU-9013423", "R-HSA-9013149", "R-DME-9035034", "R-DME-9013148", "R-HSA-8980692", "R-MMU-9013420", "R-HSA-9768727", "R-HSA-9035034", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9013148", "R-DME-9013409", "R-DME-9013406", "R-HSA-9013026", "R-HSA-9013408", "R-HSA-9013406", "R-MMU-9013149", "R-MMU-9768727", "R-DME-9013423", "R-DME-9013420"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-9035034:r:RHOF GTPase cycle", "R-DME-9013148:r:CDC42 GTPase 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{"description": "Formiminotransferase-cyclodeaminase", "go_ids": [], "go_terms": [], "name": "FTCD", "pathway_ids": ["PWY-5030", "R-MMU-70921", "R-RNO-70921", "R-HSA-70921", "R-DDI-70921"], "pathways": ["PWY-5030:t:L-histidine degradation III", "R-MMU-70921:r:Histidine catabolism", "R-RNO-70921:r:Histidine catabolism", "R-HSA-70921:r:Histidine catabolism", "R-DDI-70921:r:Histidine catabolism"], "type": "Family"}, "IPR051624": {"description": "RMD1/Sad1-interacting", "go_ids": [], "go_terms": [], "name": "RMD1/Sad1-interacting", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051625": {"description": "Diverse Signaling and Regulatory Domain-Containing Protein", "go_ids": [], "go_terms": [], "name": "Signaling_Regulatory_Domain", "pathway_ids": ["R-MMU-69473", "R-DME-983168", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-3108214", "R-HSA-69473", "R-MMU-983168", "R-MMU-3108214", "R-HSA-5693565", "R-HSA-983168", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": 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"R-HSA-9845576", "R-HSA-9035034", "R-RNO-9845576", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-MMU-9013149"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9845576:r:Glycosphingolipid transport", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9845576:r:Glycosphingolipid transport", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-9845576:r:Glycosphingolipid transport", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Family"}, "IPR051635": {"description": "Serotonin N-acetyltransferase-like", "go_ids": [], "go_terms": [], "name": 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"R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693607:r:Processing of DNA double-strand break ends", "R-BTA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Family"}, "IPR051658": {"description": "Ubiquitin-like domain-containing CTD phosphatase 1", "go_ids": ["GO:0090364"], "go_terms": ["GO:0090364:regulation of proteasome assembly:P"], "name": "UBLCP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051659": {"description": "Serine Protease S1 Domain-Containing Protein", "go_ids": [], "go_terms": [], "name": "Serine_Protease_S1-Domain", "pathway_ids": ["R-MMU-416476", "R-HSA-9657688", 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["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-RNO-6798695:r:Neutrophil degranulation", "R-RNO-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR051671": {"description": "CYSTM1 Heavy Metal Tolerance", "go_ids": [], "go_terms": [], "name": "CYSTM1_HM_Tolerance", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051673": {"description": "Single-stranded-DNA-specific exonuclease RecJ", "go_ids": [], "go_terms": [], "name": "SSDNA_exonuclease_RecJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051674": {"description": "Malate Decarboxylating Enzymes", "go_ids": [], "go_terms": [], "name": "Malate_Decarboxylase", "pathway_ids": ["PWY-7117", "PWY-241"], "pathways": ["PWY-7117:t:C4 photosynthetic carbon assimilation cycle, PEPCK type", "PWY-241:t:C4 photosynthetic carbon assimilation cycle, NADP-ME type"], "type": "Family"}, "IPR051675": {"description": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "Endo/Exo/Phosphatase_dom_1", "pathway_ids": ["R-HSA-9029569"], "pathways": ["R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "type": "Family"}, "IPR051676": {"description": "UPF0053 domain-containing protein", "go_ids": [], "go_terms": [], "name": "UPF0053_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051677": {"description": "AfsR/DnrI/RedD regulatory protein", "go_ids": [], "go_terms": [], "name": "AfsR-DnrI-RedD_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051678": {"description": "Aminoglycoside Phosphotransferase Enzymes", "go_ids": [], "go_terms": [], "name": "AGP_Transferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051679": {"description": "Divalent Anion Sodium Symporter-Related Transporters", "go_ids": [], "go_terms": [], "name": "DASS-Related_Transporters", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051680": {"description": "ATP-dependent Glutamate--Cysteine Ligase Type 2", "go_ids": [], "go_terms": [], "name": "ATP-dep_Glu-Cys_Ligase-2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051681": {"description": "Serine/Threonine Kinases and Pseudokinases", "go_ids": [], "go_terms": [], "name": "Ser/Thr_Kinases-Pseudokinases", "pathway_ids": ["R-SSC-5673000", "R-GGA-9732724", "R-HSA-9020702", "R-BTA-446353", "R-HSA-5218900", "R-HSA-168638", "R-HSA-6802952", "R-HSA-5689880", "R-MMU-9013408", "R-CEL-5673000", "R-HSA-9732724", "R-CEL-5621575", "R-MMU-5689896", "R-HSA-5675221", "R-DME-5689896", "R-CEL-446343", "R-BTA-450321", "R-MMU-5689880", "R-GGA-5675221", "R-HSA-5673000", "R-DDI-5213460", "R-HSA-168927", "R-MMU-9732724", "R-HSA-9693928", "R-HSA-450302", "R-DDI-5673000", "R-MMU-3371378", "R-HSA-937041", "R-RNO-5213460", "R-DME-1295596", "R-HSA-6802955", "R-HSA-9692913", "R-RNO-446343", "R-HSA-170984", "R-RNO-5673000", "R-RNO-2562578", "R-HSA-6802948", "R-MMU-170968", "R-RNO-9732724", "R-PFA-5689896", "R-MMU-392517", "R-MMU-5673000", "R-MMU-450321", "R-RNO-5675221", "R-CEL-5674135", "R-PFA-5673000", "R-HSA-69416", "R-DME-5675221", "R-GGA-5674135", "R-MMU-69416", "R-DDI-5674135", "R-HSA-1295596", "R-MMU-5357905", "R-HSA-5674499", "R-HSA-9726840", "R-RNO-5621575", "R-CEL-170968", "R-DME-5674499", "R-GGA-5673000", "R-HSA-392517", "R-MMU-5675221", "R-HSA-9656223", "R-MMU-5674135", "R-HSA-9705671", "R-DME-432553", "R-MMU-450302", "R-MMU-430116", "R-HSA-2672351", "R-DDI-5674499", "R-MMU-5357956", "R-HSA-5357905", "R-DME-392517", "R-BTA-209543", "R-MMU-2672351", "R-SSC-5674135", "R-HSA-9013148", "R-DME-69416", "R-MMU-5218900", "R-RNO-5674135", "R-RNO-5674499", "R-DDI-5689880", "R-MMU-202424", "R-RNO-937041", "R-PFA-430116", "R-DME-5357905", "R-DME-5218900", "R-DDI-392517", "R-MMU-5675482", "R-GGA-392517", "R-MMU-9013424", "R-CEL-430116", "R-PFA-5675221", "R-HSA-9726842", "R-DDI-5675221", "R-CEL-2672351", "R-HSA-5357956", "R-GGA-5674499", "R-HSA-187706", "R-HSA-446353", "R-HSA-933543", "R-HSA-170968", "R-MMU-2562578", "R-HSA-140534", "R-MMU-937041", "R-DME-5689880", "R-MMU-446353", "R-HSA-5674135", "R-SSC-5675221", "R-HSA-5689896", "R-BTA-202424", "R-DME-5621575", "R-HSA-430116", "R-HSA-75893", "R-HSA-9013424", "R-MMU-1295596", "R-HSA-9686347", "R-HSA-450321", "R-DDI-5675482", "R-DDI-170968", "R-RNO-392517", "R-RNO-9013424", "R-HSA-9649948", "R-HSA-446343", "R-RNO-9013408", "R-BTA-446343", "R-HSA-9013408", "R-DME-5673000", "R-MMU-75893", "R-DME-5674135", "R-MMU-140534", "R-MMU-5621575", "R-MMU-209543", "R-HSA-5675482", "R-PFA-5213460", 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"R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-170968:r:Frs2-mediated activation", "R-MMU-2562578:r:TRIF-mediated programmed cell death", "R-HSA-140534:r:Caspase activation via Death Receptors in the presence of ligand", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-446353:r:Cell-extracellular matrix interactions", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-BTA-202424:r:Downstream TCR signaling", "R-DME-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-HSA-75893:r:TNF signaling", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-HSA-9686347:r:Microbial modulation of RIPK1-mediated regulated necrosis", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation 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"R-CEL-446353:r:Cell-extracellular matrix interactions", "R-DME-3371378:r:Regulation by c-FLIP", "R-GGA-430116:r:GP1b-IX-V activation signalling", "R-CEL-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-3371378:r:Regulation by c-FLIP", "R-HSA-9013957:r:TLR3-mediated TICAM1-dependent programmed cell death", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-PFA-5689880:r:Ub-specific processing proteases", "R-RNO-430116:r:GP1b-IX-V activation signalling", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-DME-9013424:r:RHOV GTPase cycle", "R-DME-430116:r:GP1b-IX-V activation signalling", "R-DME-209214:r:Phosphorylation of SMO", "R-MMU-5213460:r:RIPK1-mediated regulated necrosis", "R-RNO-2672351:r:Stimuli-sensing channels", "R-RNO-3295583:r:TRP channels", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-MMU-168638:r:NOD1/2 Signaling 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"R-GGA-2672351:r:Stimuli-sensing channels", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-RNO-5675482:r:Regulation of necroptotic cell death", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-3295583:r:TRP channels", "R-HSA-3295583:r:TRP channels"], "type": "Family"}, "IPR051682": {"description": "Mitochondrial Persulfide Dioxygenase", "go_ids": [], "go_terms": [], "name": "Mito_Persulfide_Diox", "pathway_ids": ["R-BTA-1614517", "R-MMU-1614517", "R-HSA-1614517"], "pathways": ["R-BTA-1614517:r:Sulfide oxidation to sulfate", "R-MMU-1614517:r:Sulfide oxidation to sulfate", "R-HSA-1614517:r:Sulfide oxidation to sulfate"], "type": "Family"}, "IPR051683": {"description": "Enoyl-CoA Hydratase/Isomerase Domain-Containing Protein", "go_ids": [], "go_terms": [], "name": "Enoyl-CoA_Hydratase/Isomerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051684": {"description": "Electron Transfer/Redox Process", "go_ids": [], "go_terms": [], "name": "Electron_Trans/Redox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051685": {"description": "Ycf3/AcsC/BcsC/TPR Multifunctional", "go_ids": [], "go_terms": [], "name": "Ycf3/AcsC/BcsC/TPR_MFPF", "pathway_ids": ["R-MMU-6804760", "R-HSA-9931953", "R-RNO-6804760"], "pathways": ["R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9931953:r:Biofilm formation", "R-RNO-6804760:r:Regulation of TP53 Activity through Methylation"], "type": "Family"}, "IPR051686": {"description": "Outer membrane lipoprotein DolP", "go_ids": [], "go_terms": [], "name": "Lipoprotein_DolP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051687": {"description": "Peroxisomal Beta-Oxidation Enzymes", "go_ids": [], "go_terms": [], "name": "Peroxisomal_Beta-Oxidation", "pathway_ids": ["PWY-6944", "PWY-6920", "PWY-7288", "PWY-7339", "PWY-5138", "PWY-8152", "PWY-5972", "PWY-7338", "PWY-7340", "PWY-6657", "PWY-7337", "R-MMU-2046106", "R-MMU-193368", "R-DME-9033241", "R-DME-389887", "R-RNO-2046106", "R-HSA-389887", "R-HSA-193368", "R-MMU-9033241", "R-DME-2046106", "R-RNO-9033241", "R-MMU-389887", "R-DME-193368", "R-RNO-389887", "R-HSA-390247", "R-MMU-390247", "R-RNO-193368", "R-HSA-9033500", "R-DME-390247", "R-HSA-2046106", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-5138:t:fatty acid beta-oxidation IV (unsaturated, even number)", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DME-9033241:r:Peroxisomal protein import", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Family"}, "IPR051688": {"description": "Universal stress protein A", "go_ids": [], "go_terms": [], "name": "USP_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051689": {"description": "Sterol desaturase/TMEM195-like", "go_ids": [], "go_terms": [], "name": "Sterol_desaturase/TMEM195", "pathway_ids": ["R-DRE-75109", "R-HSA-75109", "R-MMU-75109", "R-CEL-75109", "R-XTR-75109", "R-RNO-75109"], "pathways": ["R-DRE-75109:r:Triglyceride biosynthesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-MMU-75109:r:Triglyceride biosynthesis", "R-CEL-75109:r:Triglyceride biosynthesis", "R-XTR-75109:r:Triglyceride biosynthesis", "R-RNO-75109:r:Triglyceride biosynthesis"], "type": "Family"}, "IPR051690": {"description": "PseI/Nans/NeuA/B acid synthases", "go_ids": [], "go_terms": [], "name": "PseI-like", "pathway_ids": ["R-MMU-4085001", "R-HSA-4085001", "R-DME-4085001"], "pathways": ["R-MMU-4085001:r:Sialic acid metabolism", "R-HSA-4085001:r:Sialic acid metabolism", "R-DME-4085001:r:Sialic acid metabolism"], "type": "Family"}, "IPR051691": {"description": "Metabolic Enzymes: Cyanogenesis, Opine Oxidation, G-3-P Dehydrogenation", "go_ids": [], "go_terms": [], "name": "Metab_Enz_Cyan_OpOx_G3PDH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051692": {"description": "Outer Membrane Porin-like", "go_ids": [], "go_terms": [], "name": "OMP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051693": {"description": "UPF0046 metallophosphoesterase", "go_ids": [], "go_terms": [], "name": "UPF0046_metallophosphoest", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051694": {"description": "Immunoregulatory Receptor-like", "go_ids": [], "go_terms": [], "name": "Immunoregulatory_rcpt-like", "pathway_ids": ["R-HSA-198933", "R-MMU-198933"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "type": "Family"}, "IPR051695": {"description": "Phosphoglycerate Mutase", "go_ids": [], "go_terms": [], "name": "Phosphoglycerate_Mutase", "pathway_ids": ["R-HSA-5628897", "R-XTR-5628897", "R-BTA-5628897", "R-DRE-5628897", "R-MMU-5628897"], "pathways": ["R-HSA-5628897:r:TP53 Regulates Metabolic Genes", "R-XTR-5628897:r:TP53 Regulates Metabolic Genes", "R-BTA-5628897:r:TP53 Regulates Metabolic Genes", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Family"}, "IPR051696": {"description": "DENN Domain-Containing GEFs", "go_ids": [], "go_terms": [], "name": "DENN_Domain_GEFs", "pathway_ids": ["R-SPO-8876198", "R-DME-8876198", "R-HSA-8876198", "R-MMU-8876198"], "pathways": ["R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Family"}, "IPR051697": {"description": "Patched domain-containing protein", "go_ids": [], "go_terms": [], "name": "Patched_domain-protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051698": {"description": "Transposase 11", "go_ids": [], "go_terms": [], "name": "YncI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051699": {"description": "Rpn/YhgA-like nuclease", "go_ids": [], "go_terms": [], "name": "Rpn/YhgA-like_nuclease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051700": {"description": "STE20 Ser/Thr Protein Kinase", "go_ids": [], "go_terms": [], "name": 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"R-SPO-9603798:r:Class I peroxisomal membrane protein import", "R-RNO-9603798:r:Class I peroxisomal membrane protein import", "R-CEL-9603798:r:Class I peroxisomal membrane protein import", "R-MMU-9603798:r:Class I peroxisomal membrane protein import", "R-HSA-9603798:r:Class I peroxisomal membrane protein import", "R-DRE-9603798:r:Class I peroxisomal membrane protein import"], "type": "Family"}, "IPR051702": {"description": "SH3 domain-containing protein YSC84-like", "go_ids": [], "go_terms": [], "name": "SH3_domain_YSC84-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051703": {"description": "NF-kappa-B Signaling Regulator", "go_ids": [], "go_terms": [], "name": "NF-kappa-B_Signaling_Reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051704": {"description": "Flavin-dependent aromatic-ring hydroxylase", "go_ids": [], "go_terms": [], "name": "FAD_aromatic-hydroxylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051705": {"description": 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plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane"], "type": "Family"}, "IPR051708": {"description": "Plant Aspartic Proteinase A1", "go_ids": [], "go_terms": [], "name": "Plant_Aspart_Prot_A1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051709": {"description": "Ubiquitin ligases and GTPase regulators", "go_ids": [], "go_terms": [], "name": "Ub-ligase/GTPase-reg", "pathway_ids": ["PWY-7511", "R-HSA-168928", "R-HSA-9833482", "R-MMU-983168", "R-HSA-1169408", "R-HSA-9833110", "R-HSA-936440", "R-HSA-983168", "R-RNO-983168", "R-HSA-9909505"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes"], "type": "Family"}, "IPR051710": {"description": "Phosphatase and SH3 domain-containing protein", "go_ids": [], "go_terms": [], "name": "Phosphatase_SH3-domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051712": {"description": "Mono-ADP-ribosyltransferase and antiviral protein", "go_ids": [], "go_terms": [], "name": "ARTD-AVP", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-HSA-6802952"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Family"}, "IPR051713": {"description": "T-cell Activation and Immune Regulation Protein", "go_ids": [], "go_terms": [], "name": "T-cell_Activation_Regulation", "pathway_ids": ["R-MMU-389948", "R-HSA-9931269", "R-MMU-389359", "R-HSA-9929491", "R-MMU-6811558", "R-HSA-9701898", "R-HSA-2219530", "R-MMU-1257604", "R-HSA-6811558", "R-MMU-389513", "R-MMU-389356", "R-MMU-389357", "R-HSA-389356", "R-MMU-9931295", "R-HSA-9929356", "R-HSA-389359", "R-MMU-9931269", "R-HSA-389357", "R-MMU-9929491", "R-MMU-9929356", "R-HSA-9909620", "R-HSA-1257604", "R-HSA-389948", "R-HSA-6783783", "R-HSA-9931295", "R-HSA-389513"], "pathways": ["R-MMU-389948:r:Co-inhibition by PD-1", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-MMU-389359:r:CD28 dependent Vav1 pathway", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-389356:r:Co-stimulation by CD28", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-389359:r:CD28 dependent Vav1 pathway", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9909620:r:Regulation of PD-L1(CD274) translation", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-6783783:r:Interleukin-10 signaling", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-389513:r:Co-inhibition by CTLA4"], "type": "Family"}, "IPR051714": {"description": "CCHC-type Zinc Finger Nucleic Acid Binding", "go_ids": [], "go_terms": [], "name": "Znf_CCHC_NABP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051715": {"description": "Intimin/Invasin domain-containing protein", "go_ids": [], "go_terms": [], "name": "Intimin-Invasin_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051716": {"description": "Plant receptor-like serine/threonine kinase", "go_ids": [], "go_terms": [], "name": "Plant_RL_S/T_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051717": {"description": "Major facilitator superfamily MFSD6", "go_ids": [], "go_terms": [], "name": "MFS_MFSD6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051718": {"description": "ADP Ribosylation Factor GTPase-Activating", "go_ids": [], "go_terms": [], "name": "ARF_GTPase-activating", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051719": {"description": "Cytosolic arginine sensor for mTORC1", "go_ids": [], "go_terms": [], "name": "CASTOR_mTORC1", "pathway_ids": ["R-RNO-9639288", "R-MMU-9639288", "R-HSA-9639288", "R-XTR-9639288", "R-BTA-9639288"], "pathways": ["R-RNO-9639288:r:Amino acids regulate mTORC1", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-XTR-9639288:r:Amino acids regulate mTORC1", "R-BTA-9639288:r:Amino acids regulate mTORC1"], "type": "Family"}, "IPR051720": {"description": "rRNA N6-Adenosine-Methyltransferase/Polyamine Synthase", "go_ids": [], "go_terms": [], "name": 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"IPR051725": {"description": "SAM and SH3 domain-containing protein", "go_ids": [], "go_terms": [], "name": "SAM-SH3_domain_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051726": {"description": "Chitin Synthase Regulator", "go_ids": [], "go_terms": [], "name": "Chitin_Synth_Reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051727": {"description": "DnaJ Homolog Subfamily C Member 3 Co-Chaperones", "go_ids": [], "go_terms": [], "name": "DnaJ_C3_Co-chaperones", "pathway_ids": ["R-RNO-381426", "R-HSA-6798695", "R-MMU-9833482", "R-HSA-381038", "R-RNO-8957275", "R-HSA-9833482", "R-MMU-381426", "R-RNO-9833482", "R-HSA-9918432", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-RNO-6798695", "R-HSA-192823"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-9918432:r:Maturation of DENV proteins", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-192823:r:Viral mRNA Translation"], "type": "Family"}, "IPR051728": {"description": "RING-FYVE domain-containing E3 ubiquitin-protein ligase", "go_ids": [], "go_terms": [], "name": "RING-FYVE_E3_ubiquitin-ligase", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-RNO-6804757", "R-HSA-6804757", "R-MMU-6804757", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168", "R-BTA-6804757"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-6804757:r:Regulation of TP53 Degradation"], "type": "Family"}, "IPR051729": {"description": "Opine/Lysopine Dehydrogenase", "go_ids": [], "go_terms": [], "name": "Opine/Lysopine_DH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051730": {"description": "Nuclear autoantigenic sperm protein-like", "go_ids": [], "go_terms": [], "name": "NASP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051731": {"description": "DENND11/AVL9 guanine nucleotide exchange factors", "go_ids": [], "go_terms": [], "name": "DENND11/AVL9_GEFs", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051732": {"description": "Upstream Stimulatory Factor", "go_ids": [], "go_terms": [], "name": "USF", "pathway_ids": ["R-BTA-9824585", "R-MMU-9824585", "R-HSA-9018519", "R-HSA-9824585", "R-MMU-9018519", "R-BTA-9018519"], "pathways": ["R-BTA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-BTA-9018519:r:Estrogen-dependent gene expression"], "type": "Family"}, "IPR051733": {"description": "WD repeat-containing DCAF13/WDSOF1", "go_ids": [], "go_terms": [], "name": "WD_repeat_DCAF13/WDSOF1", "pathway_ids": ["R-MMU-8951664", "R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-HSA-6791226", "R-HSA-8951664", "R-DDI-6791226", "R-DRE-8951664", "R-SPO-8951664", "R-XTR-8951664", "R-SPO-6791226", "R-HSA-6790901", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-8951664:r:Neddylation", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-XTR-8951664:r:Neddylation", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-DDI-8951664:r:Neddylation"], "type": "Family"}, "IPR051734": {"description": "Type II toxin-antitoxin VapB antitoxins", "go_ids": [], "go_terms": [], "name": "VapB_TA_antitoxins", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051735": {"description": "CFEM domain-containing protein", "go_ids": [], "go_terms": [], "name": "CFEM_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051736": {"description": "DnaJ homolog subfamily B member 11-like", "go_ids": [], "go_terms": [], "name": "DnaJ-B11-like", "pathway_ids": ["R-HSA-381038", "R-HSA-9918432"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Family"}, "IPR051737": {"description": "L-xylulose reductase/Carbonyl reductase", "go_ids": [], "go_terms": [], "name": "L-xylulose/Carbonyl_redctase", "pathway_ids": ["PWY-5515", "PWY-5525", "R-HSA-5661270", "R-RNO-5661270", "R-CEL-5661270", "R-HSA-5662853", "R-GGA-5661270", "R-MMU-5661270", "R-BTA-5661270"], "pathways": ["PWY-5515:t:L-arabinose degradation II", "PWY-5525:t:D-glucuronate degradation I", "R-HSA-5661270:r:Formation of xylulose-5-phosphate", "R-RNO-5661270:r:Formation of xylulose-5-phosphate", "R-CEL-5661270:r:Formation of xylulose-5-phosphate", "R-HSA-5662853:r:Essential pentosuria", "R-GGA-5661270:r:Formation of xylulose-5-phosphate", "R-MMU-5661270:r:Formation of xylulose-5-phosphate", "R-BTA-5661270:r:Formation of xylulose-5-phosphate"], "type": "Family"}, "IPR051738": {"description": "Scaffold Attachment Factor and Modulators", "go_ids": [], "go_terms": [], "name": "SAF_Modulators", "pathway_ids": ["R-CEL-3899300", "R-MMU-3899300", "R-RNO-3899300", "R-HSA-3899300"], "pathways": ["R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-3899300:r:SUMOylation of transcription cofactors", "R-HSA-3899300:r:SUMOylation of transcription cofactors"], "type": "Family"}, "IPR051739": {"description": "Rhomboid-related Intramembrane Serine Proteases", "go_ids": [], "go_terms": [], "name": "Rhomboid_IM_Serine_Proteases", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051740": {"description": "Double-stranded RNA-binding domain-containing protein", "go_ids": [], "go_terms": [], "name": "DRBM-containing_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051741": {"description": "Partitioning defective 6 homolog protein", "go_ids": [], "go_terms": [], "name": "PAR6_homolog", "pathway_ids": ["R-MMU-420029", "R-HSA-9013420", "R-RNO-4608870", "R-HSA-2173791", "R-HSA-420029", "R-MMU-2173791", "R-CEL-9013424", "R-RNO-9013149", "R-MMU-9013424", "R-HSA-9013424", "R-RNO-420029", "R-CEL-9013149", "R-RNO-2173791", "R-HSA-9013149", "R-HSA-4608870", "R-MMU-9013420", "R-RNO-9013424", "R-MMU-9013149", "R-HSA-9013148", "R-CEL-9013420", "R-RNO-9013420", "R-MMU-4608870"], "pathways": ["R-MMU-420029:r:Tight junction interactions", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-420029:r:Tight junction interactions", "R-MMU-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-CEL-9013424:r:RHOV GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-RNO-420029:r:Tight junction interactions", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-2173791:r:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-9013420:r:RHOU GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-CEL-9013420:r:RHOU GTPase cycle", "R-RNO-9013420:r:RHOU GTPase cycle", "R-MMU-4608870:r:Asymmetric localization of PCP proteins"], "type": "Family"}, "IPR051743": {"description": "TAFA chemokine-like", "go_ids": [], "go_terms": [], "name": "TAFA_chemokine-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051744": {"description": "AP2-associated Ser/Thr protein kinase", "go_ids": [], "go_terms": [], "name": "AP2_assoc_SerThr_kinase", "pathway_ids": ["R-RNO-8856828", "R-MMU-8856828", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828"], "pathways": ["R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis"], "type": "Family"}, "IPR051745": {"description": "Intracellular Transport Effector", "go_ids": [], "go_terms": [], "name": "Intracell_Transport_Effector", "pathway_ids": ["R-HSA-264876", "R-HSA-8986944", "R-MMU-9824585", "R-HSA-9824585", "R-RNO-9824585"], "pathways": ["R-HSA-264876:r:Insulin processing", "R-HSA-8986944:r:Transcriptional Regulation by MECP2", "R-MMU-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-RNO-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation"], "type": "Family"}, "IPR051746": {"description": "Kelch domain-containing protein 8", "go_ids": [], "go_terms": [], "name": "Kelch_domain_containing_8", "pathway_ids": ["R-DDI-983168", "R-DDI-9755511", "R-DDI-4641258", "R-DDI-5658442", "R-DDI-8951664"], "pathways": ["R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-DDI-8951664:r:Neddylation"], "type": "Family"}, "IPR051747": {"description": "Angiomotin-like", "go_ids": [], "go_terms": [], "name": "Angiomotin-like", "pathway_ids": ["R-BTA-2028269", "R-DRE-2028269", "R-MMU-2028269", "R-RNO-2028269", "R-HSA-9762292", "R-CFA-2028269", "R-MMU-9762292", "R-HSA-2028269"], "pathways": ["R-BTA-2028269:r:Signaling by Hippo", "R-DRE-2028269:r:Signaling by Hippo", "R-MMU-2028269:r:Signaling by Hippo", "R-RNO-2028269:r:Signaling by Hippo", "R-HSA-9762292:r:Regulation of CDH11 function", "R-CFA-2028269:r:Signaling by Hippo", "R-MMU-9762292:r:Regulation of CDH11 function", "R-HSA-2028269:r:Signaling by Hippo"], "type": "Family"}, "IPR051748": {"description": "Tumor Necrosis Factor Ligand Superfamily", "go_ids": [], "go_terms": [], "name": "TNF_Ligand_Superfamily", "pathway_ids": ["R-HSA-5668541", "R-MMU-5676594", "R-MMU-5668541", "R-HSA-5676594", "R-HSA-5669034", "R-HSA-450520", "R-MMU-5669034", "R-MMU-450520", "R-DME-450520"], "pathways": ["R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-MMU-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-5676594:r:TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-HSA-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-MMU-450520:r:HuR (ELAVL1) binds and stabilizes mRNA", "R-DME-450520:r:HuR (ELAVL1) binds and stabilizes mRNA"], "type": "Family"}, "IPR051750": {"description": "Cystathionine gamma-synthase-like", "go_ids": [], "go_terms": [], "name": "Cyst_gamma_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051751": {"description": "Immunoreceptor signaling adapters", "go_ids": [], "go_terms": [], "name": "Immunoreceptor_sig_adapters", "pathway_ids": ["R-MMU-202433", "R-HSA-983695", "R-MMU-2871809", "R-HSA-2424491", "R-HSA-202433", "R-RNO-983695", "R-HSA-2871796", "R-MMU-114604", "R-MMU-2424491", "R-HSA-2871809", "R-HSA-912631", "R-HSA-9679191", "R-MMU-983695", "R-HSA-114604", "R-MMU-2871796"], "pathways": ["R-MMU-202433:r:Generation of second messenger molecules", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-202433:r:Generation of second messenger molecules", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-2424491:r:DAP12 signaling", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-912631:r:Regulation of signaling by CBL", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-2871796:r:FCERI mediated MAPK activation"], "type": "Family"}, "IPR051752": {"description": "Mitochondrial 2-oxodicarboxylate carrier", "go_ids": [], "go_terms": [], "name": "Mito_2-oxodicarb_carrier", "pathway_ids": ["R-MMU-71064", "R-DDI-71064", "R-BTA-71064", "R-RNO-71064", "R-HSA-71064"], "pathways": ["R-MMU-71064:r:Lysine catabolism", "R-DDI-71064:r:Lysine catabolism", "R-BTA-71064:r:Lysine catabolism", "R-RNO-71064:r:Lysine catabolism", "R-HSA-71064:r:Lysine catabolism"], "type": "Family"}, "IPR051753": {"description": "Retinoic acid-inducible GPCR family 3", "go_ids": [], "go_terms": [], "name": "RA-inducible_GPCR3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051755": {"description": "Immunoglobulin-like Cell Surface Receptor", "go_ids": [], "go_terms": [], "name": "Ig-like_CS_Receptor", "pathway_ids": ["R-HSA-6798695", "R-RNO-2172127", "R-RNO-202733", "R-MMU-391160", "R-MMU-202733", "R-HSA-2172127", "R-MMU-6798695", "R-RNO-391160", "R-MMU-2172127", "R-RNO-6798695", "R-HSA-391160", "R-HSA-202733"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-RNO-2172127:r:DAP12 interactions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-391160:r:Signal regulatory protein family interactions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-HSA-2172127:r:DAP12 interactions", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-391160:r:Signal regulatory protein family interactions", "R-MMU-2172127:r:DAP12 interactions", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-391160:r:Signal regulatory protein family interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR051756": {"description": "Centrosomal microtubule-associated protein", "go_ids": [], "go_terms": [], "name": "Centrosomal_MT-associated", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-HSA-380284", "R-MMU-380270", "R-HSA-380270", "R-RNO-5620912", "R-HSA-8854518", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-RNO-380259", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Family"}, "IPR051757": {"description": "Beta-galactoside alpha2-3 sialyltransferases", "go_ids": [], "go_terms": [], "name": "Beta-gal_alpha2-3_sialyltrans", "pathway_ids": ["R-RNO-9840309", "R-MMU-9840309", "R-RNO-2022854", "R-RNO-4085001", "R-MMU-977068", "R-HSA-9683673", "R-HSA-4085001", "PWY-7838", "PWY-7832", "PWY-7836", "PWY-7433", "R-HSA-9694719", "R-HSA-977068", "R-GGA-4085001", "R-HSA-9694548", "R-MMU-2022854", "R-GGA-2022854", "R-RNO-977068", "R-HSA-2022854", "R-HSA-9840309", "R-MMU-4085001", "R-GGA-977068"], "pathways": ["R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis", "R-RNO-2022854:r:Keratan sulfate biosynthesis", "R-RNO-4085001:r:Sialic acid metabolism", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-9683673:r:Maturation of protein 3a", "R-HSA-4085001:r:Sialic acid metabolism", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-7832:t:ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide", "PWY-7836:t:ganglio-series glycosphingolipids biosynthesis", "PWY-7433:t:mucin core 1 and core 2 O-glycosylation", "R-HSA-9694719:r:Maturation of protein 3a", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-GGA-4085001:r:Sialic acid metabolism", "R-HSA-9694548:r:Maturation of spike protein", "R-MMU-2022854:r:Keratan sulfate biosynthesis", "R-GGA-2022854:r:Keratan sulfate biosynthesis", "R-RNO-977068:r:Termination of O-glycan biosynthesis", "R-HSA-2022854:r:Keratan sulfate biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-4085001:r:Sialic acid metabolism", "R-GGA-977068:r:Termination of O-glycan biosynthesis"], "type": "Family"}, "IPR051758": {"description": "Ethylene-responsive transcription factor ERF/AP2-like", "go_ids": [], "go_terms": [], "name": "ERF/AP2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051759": {"description": "LIM and SH3 domain-containing protein", "go_ids": [], "go_terms": [], "name": "LIM-SH3_domain_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051760": {"description": "Histone-lysine N-methyltransferase KMT5A", "go_ids": [], "go_terms": [], "name": "KMT5A", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-MMU-6804760", "R-DRE-6804760", "R-MMU-3214841", "R-XTR-3214841", "R-XTR-6804760", "R-XTR-9764725", "R-BTA-9764725", "R-CEL-3214841", "R-HSA-9764725", "R-BTA-2299718", "R-HSA-6804760", "R-BTA-6804760", "R-MMU-9764725", "R-BTA-3214841", "R-XTR-2299718", "R-DRE-3214841", "R-HSA-3214841", "R-CEL-9764725", "R-DME-3214841", "R-DME-9764725", "R-DME-6804760", "R-HSA-2299718", "R-DRE-2299718", "R-DRE-9764725"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-DRE-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-XTR-3214841:r:PKMTs methylate histone lysines", "R-XTR-6804760:r:Regulation of TP53 Activity through Methylation", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-2299718:r:Condensation of Prophase Chromosomes", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-BTA-6804760:r:Regulation of TP53 Activity through Methylation", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-BTA-3214841:r:PKMTs methylate histone lysines", "R-XTR-2299718:r:Condensation of Prophase Chromosomes", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-CEL-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-3214841:r:PKMTs methylate histone lysines", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DME-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-2299718:r:Condensation of Prophase Chromosomes", "R-DRE-2299718:r:Condensation of Prophase Chromosomes", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription"], "type": "Family"}, "IPR051761": {"description": "MLP-like hydrophobic ligand-binding", "go_ids": [], "go_terms": [], "name": "MLP-like_ligand-binding", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051762": {"description": "Upstream Binding Factor 1", "go_ids": [], "go_terms": [], "name": "UBF1", "pathway_ids": ["R-HSA-73728", "R-HSA-73772", "R-HSA-73863", "R-MMU-73762", "R-RNO-73772", "R-CEL-9837999", "R-MMU-73728", "R-CEL-140342", "R-HSA-427413", "R-MMU-73863", "R-RNO-73728", "R-MMU-73772", "R-RNO-73863", "R-HSA-73762", "R-CEL-163282", "R-RNO-73762"], "pathways": ["R-HSA-73728:r:RNA Polymerase I Promoter Opening", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-RNO-73772:r:RNA Polymerase I Promoter Escape", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-MMU-73728:r:RNA Polymerase I Promoter Opening", "R-CEL-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-RNO-73728:r:RNA Polymerase I Promoter Opening", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-RNO-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-CEL-163282:r:Mitochondrial transcription initiation", "R-RNO-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Family"}, "IPR051764": {"description": "Avidin/Streptavidin-related", "go_ids": [], "go_terms": [], "name": "Avidin/Streptavidin-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051765": {"description": "Pleckstrin homology domain-containing family F", "go_ids": [], "go_terms": [], "name": "PH_domain-containing_F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051766": {"description": "Thioredoxin domain-containing protein", "go_ids": [], "go_terms": [], "name": "TXND_domain-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051767": {"description": "Nucleoporin NUP42 domain-containing protein", "go_ids": [], "go_terms": [], "name": "Nucleoporin_NUP42", "pathway_ids": ["R-HSA-180910", "R-SPO-3371453", "R-XTR-4615885", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-SPO-159227", "R-DRE-3232142", "R-SPO-159231", "R-DRE-159231", "R-MMU-3232142", "R-MMU-4570464", "R-DRE-4551638", "R-XTR-159236", "R-HSA-170822", "R-HSA-1169408", "R-DRE-191859", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-DRE-159236", "R-DRE-3108214", "R-MMU-4085377", "R-HSA-3371453", "R-MMU-4551638", "R-HSA-165054", "R-HSA-4570464", "R-XTR-170822", "R-SPO-4085377", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-XTR-191859", "R-HSA-168276", "R-SPO-159236", "R-HSA-168271", "R-HSA-6784531", "R-SPO-4551638", "R-MMU-3301854", "R-XTR-3371453", "R-HSA-4085377", "R-HSA-168325", "R-XTR-4085377", "R-XTR-3301854", "R-HSA-9609690", "R-DRE-3371453", "R-MMU-170822", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-SPO-4570464", "R-DRE-3301854", "R-DRE-159227", "R-HSA-5619107", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-XTR-3108214"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DRE-191859:r:snRNP Assembly", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-XTR-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-XTR-191859:r:snRNP Assembly", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-XTR-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9609690:r:HCMV Early Events", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", 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{"description": "Intermembrane Transport Protein PqiA/PqiB", "go_ids": [], "go_terms": [], "name": "PqiA-PqiB_transport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051801": {"description": "Glycosyl_Hydrolase_28_Enzymes", "go_ids": [], "go_terms": [], "name": "GH28_Enzymes", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051802": {"description": "Alpha-2-macroglobulin-like", "go_ids": [], "go_terms": [], "name": "YfhM-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051803": {"description": "Type II TA system RelE-like toxin", "go_ids": [], "go_terms": [], "name": "TA_system_RelE-like_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051804": {"description": "Carbohydrate Metabolism Regulated Kinase/Isomerase", "go_ids": [], "go_terms": [], "name": "Carb_Metab_Reg_Kinase/Isom", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051805": {"description": "Dehydratase Activator and Reductase Protein", "go_ids": [], 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"PWY-7650:t:echinocandin B biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation", "PWY-7430:t:indole degradation to anthranil and anthranilate", "PWY-7705:t:quinolinone B biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-5412:t:levopimaric acid biosynthesis", "PWY-7687:t:stipitatate biosynthesis", "PWY-8087:t:indole-3-acetate degradation II", "PWY-321:t:cutin biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7698:t:2,5-xylenol and 3,5-xylenol degradation", "PWY-2421:t:indole-3-acetate degradation I", "PWY-7513:t:flaviolin dimer and mompain biosynthesis", "PWY-8111:t:carbaryl degradation", "PWY-5434:t:(3E)-4,8-dimethylnona-1,3,7-triene biosynthesis I", "PWY-6552:t:caffeine degradation I (main, plants)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7937:t:fungal bioluminescence", "PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-7638:t:echinenone and zeaxanthin biosynthesis (Synechocystis)", "PWY-5413:t:neoabietic acid biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5414:t:palustric acid biosynthesis", "PWY-7949:t:diadinoxanthin and diatoxanthin interconversion", "PWY-7749:t:(-)-4'-demethyl-epipodophyllotoxin biosynthesis", "PWY-1381:t:fluorene degradation II", "PWY-7085:t:triethylamine degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-7304:t:3-amino-4,7-dihydroxy-coumarin biosynthesis", "PWY-7492:t:paspaline biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-5422:t:isopimaric acid biosynthesis", "PWY-6708:t:ubiquinol-8 biosynthesis (early decarboxylation)", "PWY-5846:t:colchicine biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6710:t:poly-hydroxy fatty acids biosynthesis", "PWY-7011:t:2-isopropylphenol degradation", "PWY-7481:t:oryzalide A biosynthesis", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-7637:t:2,2'-dihydroxyketocarotenoids biosynthesis", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7775:t:propane degradation II", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-7780:t:butane degradation", "PWY-7703:t:2,4-xylenol degradation to protocatechuate"], "type": "Family"}, "IPR051821": {"description": "Aspartyl/Asparaginyl beta-hydroxylase domain-containing protein", "go_ids": [], "go_terms": [], "name": "Asp/Asn_beta-hydroxylase", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-6919:t:neopentalenoketolactone and pentalenate biosynthesis", "PWY-7706:t:dapdiamides biosynthesis", "PWY-5349:t:esculetin biosynthesis", "PWY-5036:t:gibberellin biosynthesis II (early C-3 hydroxylation)", "PWY-5070:t:gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)", "PWY-8360:t:hectochlorin biosynthesis", "PWY-7648:t:3-hydroxy-4-methyl-proline biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-7274:t:D-cycloserine biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-1187:t:glucosinolate biosynthesis from homomethionine", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-5035:t:gibberellin biosynthesis III (early C-13 hydroxylation)", "PWY-102:t:gibberellin inactivation I (2beta-hydroxylation)", "PWY-7693:t:guadinomine B biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-5047:t:gibberellin biosynthesis IV (Gibberella fujikuroi)", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR051822": {"description": "Glycosyl Hydrolase Family 84", "go_ids": [], "go_terms": [], "name": "Glycosyl_Hydrolase_84", "pathway_ids": ["PWY-7437"], "pathways": ["PWY-7437:t:protein O-[N-acetyl]-glucosylation"], "type": "Family"}, "IPR051824": {"description": "LRR Receptor-Like Ser/Thr Protein Kinase", "go_ids": [], "go_terms": [], "name": "LRR_Rcpt-Like_S/T_Kinase", "pathway_ids": ["R-HSA-975155", "R-HSA-9020702", "R-HSA-975871", "R-HSA-166058", "R-HSA-975138", "R-MMU-6811558", "R-MMU-9020702", "R-HSA-5603041", "R-HSA-975110", "R-MMU-1257604", "R-HSA-1257604", "R-CEL-9020702", "R-HSA-5603037", "R-HSA-6811558"], "pathways": ["R-HSA-975155:r:MyD88 dependent cascade initiated on endosome", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-975871:r:MyD88 cascade initiated on plasma membrane", "R-HSA-166058:r:MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-975138:r:TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-9020702:r:Interleukin-1 signaling", "R-HSA-5603041:r:IRAK4 deficiency (TLR2/4)", "R-HSA-975110:r:TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-CEL-9020702:r:Interleukin-1 signaling", "R-HSA-5603037:r:IRAK4 deficiency (TLR5)", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "type": "Family"}, "IPR051825": {"description": "SRC Kinase Signaling Inhibitor", "go_ids": [], "go_terms": [], "name": "SRCIN1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051826": {"description": "E3 ubiquitin-protein ligase domain-containing protein", "go_ids": [], "go_terms": [], "name": "E3_ubiquitin-ligase_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051827": {"description": "CRISPR-associated exonuclease Cas4", "go_ids": [], "go_terms": [], "name": "Cas4_exonuclease", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-HSA-5693579", "R-HSA-69473", "R-HSA-9704646", "R-HSA-9709603", "R-HSA-69166", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-9704331", "R-HSA-5693554", "R-HSA-174437", "R-HSA-5693568", "R-HSA-5685938", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Family"}, "IPR051828": {"description": "HAD-like hydrolase domain-containing protein", "go_ids": [], "go_terms": [], "name": "HAD-like_hydrolase_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051830": {"description": "Neurogenic locus notch homolog", "go_ids": [], "go_terms": [], "name": "NOTCH_homolog", "pathway_ids": ["R-RNO-9013507"], "pathways": ["R-RNO-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus"], "type": "Family"}, "IPR051831": {"description": "Bromodomain-containing", "go_ids": [], "go_terms": [], "name": "Bromodomain_contain_prot", "pathway_ids": ["R-HSA-9933947", "R-MMU-9933939", "R-HSA-9933939", "R-XTR-9933947", "R-HSA-6804758", "R-MMU-9933947", "R-MMU-6804758", "R-DRE-9933947"], "pathways": ["R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-XTR-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-DRE-9933947:r:Formation of the non-canonical BAF (ncBAF) complex"], "type": "Family"}, "IPR051832": {"description": "Regulators of mTOR signaling and Rac activation", "go_ids": [], "go_terms": [], "name": "mTOR-Rac_regulators", "pathway_ids": ["R-HSA-9013409", "R-HSA-193648", "R-MMU-9013106", "R-MMU-8980692", "R-MMU-9013408", "R-HSA-416482", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-8948751", "R-HSA-9013106", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013406", "R-MMU-9013026", "R-MMU-416482", "R-HSA-9013148", "R-MMU-193648", "R-HSA-8948751", "R-HSA-9013026", "R-HSA-9013408", "R-HSA-9013406", "R-MMU-9013149"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Family"}, "IPR051833": {"description": "Transcription-coupled DNA damage response regulator-like", "go_ids": [], "go_terms": [], "name": "TC-DDR_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051834": {"description": "RING finger E3 ubiquitin-protein ligase", "go_ids": [], "go_terms": [], "name": "RING_finger_E3_ligase", "pathway_ids": ["PWY-7511", "R-DME-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR051835": {"description": "RAC1-specific guanine nucleotide exchange factor", "go_ids": [], "go_terms": [], "name": "RAC1-GEF", "pathway_ids": ["R-MMU-9035034", "R-HSA-9013149", "R-HSA-8980692", "R-HSA-9035034", "R-RNO-9035034", "R-MMU-8980692", "R-MMU-399955", "R-RNO-8980692", "R-HSA-399955", "R-HSA-9013148", "R-RNO-9013149", "R-RNO-9013148", "R-MMU-9013148", "R-MMU-9013149"], "pathways": ["R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-RNO-9035034:r:RHOF GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Family"}, "IPR051836": {"description": "Kremen receptor", "go_ids": [], "go_terms": [], "name": "Kremen_rcpt", "pathway_ids": ["R-HSA-3772470", "R-HSA-201681", "R-MMU-3772470", "R-HSA-5339717", "R-RNO-3772470"], "pathways": ["R-HSA-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-MMU-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "R-HSA-5339717:r:Signaling by LRP5 mutants", "R-RNO-3772470:r:Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "type": "Family"}, "IPR051837": {"description": "Sorting Nexin/PX Domain-Containing Protein Kinase-Like", "go_ids": [], "go_terms": [], "name": "SortingNexin/PXDomain-PKLike", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051838": {"description": "Intracellular mono-ADP-ribosyltransferase ARTD/PARP", "go_ids": [], "go_terms": [], "name": "ARTD_PARP", "pathway_ids": ["PWY-7817", "PWY-7981", "PWY-7025", "PWY-6720", "PWY-5381", "PWY-7018", "PWY-7450", "PWY-6148", "PWY-5800", "R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7025:t:gentamicin biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-7018:t:paromomycin biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-5800:t:xylan biosynthesis", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein"], "type": "Family"}, "IPR051839": {"description": "Retinal determination transcriptional regulator", "go_ids": [], "go_terms": [], "name": "RD_transcriptional_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051840": {"description": "NifX/NifY domain-containing protein", "go_ids": [], "go_terms": [], "name": "NifX/NifY_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051841": {"description": "Microtubule and Golgi organization protein", "go_ids": [], "go_terms": [], "name": "MT-Golgi_org_protein", "pathway_ids": ["R-RNO-6811440", "R-MMU-380259", "R-HSA-9696270", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-HSA-380270", "R-HSA-68875", "R-HSA-6811440", "R-MMU-380284", "R-MMU-2565942", "R-MMU-380320", "R-MMU-6811440", "R-HSA-8854518", "R-HSA-2565942", "R-HSA-380320", "R-MMU-68875", "R-MMU-8854518", "R-MMU-5620912", "R-MMU-9696270", "R-HSA-380259", "R-HSA-9725370"], "pathways": ["R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-68875:r:Mitotic Prophase", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-68875:r:Mitotic Prophase", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Family"}, "IPR051842": {"description": "Ribosomal subunit uS12 prolyl hydroxylase", "go_ids": [], "go_terms": [], "name": "uS12_prolyl_hydroxylase", "pathway_ids": ["PWY-7298", "PWY-8076", "PWY-6915", "PWY-6086", "PWY-8080", "PWY-6495", "PWY-7398", "PWY-8464", "PWY-7151", "PWY-8381", "PWY-6085", "PWY-7517", "PWY-7232", "PWY-8075", "PWY-6919", "PWY-7706", "PWY-5349", "PWY-5036", "PWY-5070", "PWY-8360", "PWY-7648", "PWY-8083", "PWY-7274", "PWY-6682", "PWY-1187", "PWY-7649", "PWY-7419", "PWY-5035", "PWY-102", "PWY-7693", "PWY-8179", "PWY-5047", "PWY-7150", "PWY-8358", "R-HSA-9629569", "R-DME-9629569", "R-MMU-9629569", "R-BTA-9629569", "R-SCE-9629569", "R-SPO-9629569"], "pathways": ["PWY-7298:t:nevadensin biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-6915:t:pentalenolactone biosynthesis", "PWY-6086:t:4-chloro-2-methylphenoxyacetate degradation", "PWY-8080:t:kainate biosynthesis", "PWY-6495:t:ergotamine biosynthesis", "PWY-7398:t:coumarins biosynthesis (engineered)", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6085:t:2,4-dichlorophenoxyacetate degradation", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7232:t:gibberellin biosynthesis V", "PWY-8075:t:(Kdo)2-lipid A 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{"description": "DDB1- and CUL4-associated factor", "go_ids": [], "go_terms": [], "name": "DCAF", "pathway_ids": ["R-MMU-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-CEL-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-CEL-8951664:r:Neddylation"], "type": "Family"}, "IPR051860": {"description": "Plasmodium Circumsporozoite Invasion Protein", "go_ids": [], "go_terms": [], "name": "Plasmodium_CSP_Invasion", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051861": {"description": "NET actin-binding domain-containing protein", "go_ids": [], "go_terms": [], "name": "NET_actin-binding_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051862": {"description": "Glycosyltransferase-like domain-containing protein 1", "go_ids": [], "go_terms": [], "name": "GT-like_domain_containing_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051863": {"description": "Heavy metal-associated 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{"description": "Elongin-A domain-containing protein", "go_ids": [], "go_terms": [], "name": "Elongin-A_domain", "pathway_ids": ["R-CEL-75955", "R-MMU-6796648", "R-HSA-167238", "R-RNO-674695", "R-HSA-167243", "R-RNO-6796648", "R-RNO-75955", "R-DME-674695", "R-DME-6796648", "R-HSA-6796648", "R-DME-75955", "R-MMU-674695", "R-MMU-75955", "R-MMU-112382", "R-CEL-674695", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-75955", "R-CEL-112382", "R-HSA-167152", "R-RNO-112382", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-RNO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-RNO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-RNO-75955:r:RNA Polymerase II 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"go_terms": [], "name": "eIF2B_epsilon", "pathway_ids": ["R-SCE-72731", "R-SPO-72731", "R-HSA-72731", "R-RNO-72731", "R-MMU-72731", "R-DDI-72731"], "pathways": ["R-SCE-72731:r:Recycling of eIF2:GDP", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-DDI-72731:r:Recycling of eIF2:GDP"], "type": "Family"}, "IPR051957": {"description": "Cysteine-rich secretory LCCL domain-containing protein", "go_ids": [], "go_terms": [], "name": "CRISP-LCCL_domain", "pathway_ids": ["R-HSA-6798695", "R-MMU-6798695", "R-BTA-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR051958": {"description": "Alba-like nucleic acid-binding", "go_ids": [], "go_terms": [], "name": "Alba-like_NAB", "pathway_ids": ["R-MMU-6791226", "R-HSA-6784531", "R-HSA-6791226", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Family"}, "IPR051959": {"description": "PAK1 Kinase Regulator", "go_ids": [], "go_terms": [], "name": "PAK1-Kinase_Regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051960": {"description": "Eukaryotic Initiation Factor 2B Subunit Gamma", "go_ids": [], "go_terms": [], "name": "eIF2B_gamma", "pathway_ids": ["R-SCE-72731", "R-SPO-72731", "R-RNO-72731", "R-HSA-72731", "R-CEL-72731", "R-DDI-72731"], "pathways": ["R-SCE-72731:r:Recycling of eIF2:GDP", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-CEL-72731:r:Recycling of eIF2:GDP", "R-DDI-72731:r:Recycling of eIF2:GDP"], "type": "Family"}, "IPR051961": {"description": "Fungal Secondary Metabolite Dioxygenase", "go_ids": [], "go_terms": [], "name": "Fungal_Metabolite_Diox", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051962": {"description": "Cuticlin domain-containing protein", "go_ids": [], "go_terms": [], "name": "Cuticlin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051963": {"description": "Adhesion G protein-coupled receptor A", "go_ids": [], "go_terms": [], "name": "Adhesion_GPCR_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051964": {"description": "Multifunctional chaperone and stress response protein", "go_ids": [], "go_terms": [], "name": "Chaperone_stress_response", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051965": {"description": "Chromatin Regulation and Neuronal Gene Expression", "go_ids": [], "go_terms": [], "name": "ChromReg_NeuronalGeneExpr", "pathway_ids": ["R-BTA-3214815", "R-SCE-9837999", "R-HSA-983231", "R-SCE-140342", 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"R-MMU-72163", "R-RNO-9770562", "R-DME-72163", "R-RNO-72163", "R-CEL-72163", "R-HSA-9918481"], "pathways": ["R-DME-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-9770562:r:mRNA Polyadenylation", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-CEL-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions"], "type": "Family"}, "IPR051975": {"description": "Mitochondrial Large Ribosomal Subunit mL45", "go_ids": [], "go_terms": [], "name": "mtLSU_mL45", "pathway_ids": ["R-CEL-9937383", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-CEL-5389840", "R-MMU-5419276", "R-XTR-5419276", "R-XTR-5389840", "R-CEL-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-DME-5419276", "R-DME-5389840", "R-MMU-5389840", "R-DME-9937383", "R-XTR-9937383"], "pathways": ["R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-XTR-5419276:r:Mitochondrial translation termination", "R-XTR-5389840:r:Mitochondrial translation elongation", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DME-5419276:r:Mitochondrial translation termination", "R-DME-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-XTR-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR051976": {"description": "Synaptopodin domain-containing protein", "go_ids": [], "go_terms": [], "name": "Synaptopodin_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051977": {"description": "Rab11-interacting regulator of endocytosis and ciliogenesis", "go_ids": [], "go_terms": [], "name": "Rab11-interacting_regulator", "pathway_ids": ["R-MMU-5620916", "R-HSA-5620916", "R-DRE-5620916"], "pathways": ["R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-5620916:r:VxPx cargo-targeting to cilium"], "type": "Family"}, "IPR051978": {"description": "Rho GTPase-activating domain-containing protein", "go_ids": [], "go_terms": [], "name": "Rho-GAP_domain", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9013405", "R-CFA-9013409", "R-HSA-416550", "R-MMU-9013106", "R-RNO-9013409", "R-RNO-9696270", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9013409", "R-CFA-9013404", "R-MMU-9013148", "R-HSA-9013106", "R-MMU-9013404", "R-RNO-416550", "R-CFA-9013149", "R-HSA-8849471", "R-HSA-9013423", "R-CFA-8849471", "R-DME-9035034", "R-DME-9013148", "R-CFA-9696264", "R-CFA-9013408", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013409", "R-DME-9013406", "R-RNO-9013408", "R-RNO-9013106", "R-RNO-9013406", "R-RNO-9013404", "R-CFA-9696270", "R-HSA-9013408", "R-MMU-8849471", "R-DME-350407", "R-MMU-9035034", "R-RNO-8849471", "R-CFA-9013406", "R-CFA-9013148", "R-DME-9013149", "R-CFA-8980692", "R-DME-8980692", "R-HSA-9696270", "R-CFA-416550", "R-RNO-9013148", "R-RNO-9696273", "R-CFA-9696273", "R-HSA-9696264", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-416550", "R-CFA-9013106", "R-MMU-9013406", "R-MMU-9013026", "R-RNO-9696264", "R-HSA-9013026", "R-DME-8849471", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9013149", "R-DME-9013423", "R-HSA-9696273"], "pathways": 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zinc finger domain-containing protein", "go_ids": [], "go_terms": [], "name": "B-box_zinc_finger", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051980": {"description": "WD repeat domain-containing protein MORG1", "go_ids": [], "go_terms": [], "name": "WD_repeat_MORG1", "pathway_ids": ["R-RNO-5674135", "R-DDI-5674135", "R-DRE-5674135", "R-MMU-5674135", "R-HSA-5674135"], "pathways": ["R-RNO-5674135:r:MAP2K and MAPK activation", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation"], "type": "Family"}, "IPR051981": {"description": "Alpha-1,4-N-acetylglucosaminyltransferase", "go_ids": [], "go_terms": [], "name": "A4GCT", "pathway_ids": ["PWY-7838", "R-HSA-9840309", "R-DME-9840309", "R-DME-913709", "R-HSA-913709", "R-MMU-913709", "R-RNO-9840309", "R-MMU-9840309"], "pathways": ["PWY-7838:t:globo-series glycosphingolipids biosynthesis", "R-HSA-9840309:r:Glycosphingolipid biosynthesis", "R-DME-9840309:r:Glycosphingolipid biosynthesis", "R-DME-913709:r:O-linked glycosylation of mucins", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-RNO-9840309:r:Glycosphingolipid biosynthesis", "R-MMU-9840309:r:Glycosphingolipid biosynthesis"], "type": "Family"}, "IPR051982": {"description": "Ciliary Assembly and Mitochondrial Import", "go_ids": [], "go_terms": [], "name": "CiliaryAsmbly_MitoImport", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051983": {"description": "WD repeat and SOCS box domain-containing protein", "go_ids": [], "go_terms": [], "name": "WSB_SOCS-box_domain", "pathway_ids": ["R-MMU-8951664", "R-XTR-983168", "R-HSA-8951664", "R-MMU-983168", "R-DRE-8951664", "R-HSA-983168", "R-XTR-8951664", "R-DRE-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-8951664:r:Neddylation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR051984": {"description": "Alsin", "go_ids": [], "go_terms": [], "name": "Alsin", "pathway_ids": ["R-HSA-9013149", "R-DME-9013149", "R-MMU-8876198", "R-DME-8876198", "R-RNO-8876198", "R-RNO-9013149", "R-BTA-8876198", "R-HSA-8876198", "R-MMU-9013149"], "pathways": ["R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-BTA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Family"}, "IPR051985": {"description": "Non-receptor type tyrosine-specific phosphatase", "go_ids": [], "go_terms": [], "name": "NR_tyrosine_phosphatase", "pathway_ids": ["R-MMU-77387", "R-HSA-8849472", "R-HSA-9833482", "R-HSA-77387", "R-DME-77387", "R-MMU-982772", "R-RNO-982772", "R-DME-877312", "R-HSA-6807004", "R-DME-9860927", "R-RNO-8849472", "R-RNO-77387", "R-RNO-877312", "R-RNO-9860927", "R-HSA-982772", "R-HSA-9008059", "R-DME-9833482", "R-MMU-9833482", "R-RNO-6807004", "R-RNO-912694", "R-RNO-354192", "R-HSA-877312", "R-DME-210688", "R-MMU-912694", "R-DME-210693", "R-HSA-912694", "R-HSA-9022699", "R-MMU-6807004", "R-MMU-8849472", "R-HSA-9860927", "R-MMU-354192", "R-RNO-9833482", "R-MMU-877312", "R-MMU-9860927", "R-HSA-354192"], "pathways": ["R-MMU-77387:r:Insulin receptor recycling", "R-HSA-8849472:r:PTK6 Down-Regulation", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-77387:r:Insulin receptor recycling", "R-DME-77387:r:Insulin receptor recycling", "R-MMU-982772:r:Growth hormone receptor signaling", "R-RNO-982772:r:Growth hormone receptor signaling", "R-DME-877312:r:Regulation of IFNG signaling", "R-HSA-6807004:r:Negative regulation of MET activity", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-8849472:r:PTK6 Down-Regulation", "R-RNO-77387:r:Insulin receptor recycling", "R-RNO-877312:r:Regulation of IFNG signaling", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-982772:r:Growth hormone receptor signaling", "R-HSA-9008059:r:Interleukin-37 signaling", "R-DME-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-RNO-6807004:r:Negative regulation of MET activity", "R-RNO-912694:r:Regulation of IFNA/IFNB signaling", "R-RNO-354192:r:Integrin signaling", "R-HSA-877312:r:Regulation of IFNG signaling", "R-DME-210688:r:Dephosphorylation by PTP61F phosphatases", "R-MMU-912694:r:Regulation of IFNA/IFNB signaling", "R-DME-210693:r:STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol", "R-HSA-912694:r:Regulation of IFNA/IFNB signaling", "R-HSA-9022699:r:MECP2 regulates neuronal receptors and channels", "R-MMU-6807004:r:Negative regulation of MET activity", "R-MMU-8849472:r:PTK6 Down-Regulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-354192:r:Integrin signaling", "R-RNO-9833482:r:PKR-mediated signaling", "R-MMU-877312:r:Regulation of IFNG signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-354192:r:Integrin signaling"], "type": "Family"}, "IPR051986": {"description": "Innate Immunity and Apoptosis Regulator", "go_ids": [], "go_terms": [], "name": "Innate_Immune_Apopt_Reg", "pathway_ids": ["R-HSA-909733"], "pathways": ["R-HSA-909733:r:Interferon alpha/beta signaling"], "type": "Family"}, "IPR051987": {"description": "Sigma-2 receptor-like", "go_ids": [], "go_terms": [], "name": "Sigma-2_receptor-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051988": {"description": "Homologous Recombination Repair RAD51 Paralog", "go_ids": [], "go_terms": [], "name": "HRR_RAD51_Paralog", "pathway_ids": ["R-DDI-5693616", "R-HSA-5685942", "R-HSA-5693616", "R-BTA-5693568", "R-HSA-9704646", "R-HSA-9709603", "R-MMU-5685942", "R-MMU-5693616", "R-HSA-6796648", "R-HSA-9704331", "R-BTA-5693616", "R-BTA-5685942", "R-BTA-5693579", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5693579", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-BTA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-BTA-5685942:r:HDR through Homologous Recombination (HRR)", "R-BTA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Family"}, "IPR051989": {"description": "FK506-binding protein-like isomerase", "go_ids": [], "go_terms": [], "name": "FKBP-like_isomerase", "pathway_ids": ["R-HSA-390471"], "pathways": ["R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis"], "type": "Family"}, "IPR051990": {"description": "Cell Cycle Progression and Pre-B-cell Leukemia Transcription Factor-Interacting", "go_ids": [], "go_terms": [], "name": "CCPG1/PBIP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051991": {"description": "Mitochondrial ribosomal protein 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"R-BTA-5389840:r:Mitochondrial translation elongation", "R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DME-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR051992": {"description": "Oxidative Stress Response Regulator", "go_ids": [], "go_terms": [], "name": "OxStress_Response_Reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051993": {"description": "Glycosyltransferase 8", "go_ids": [], "go_terms": [], "name": "Glycosyltransferase_8", "pathway_ids": ["R-HSA-9926550"], "pathways": ["R-HSA-9926550:r:Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition"], "type": "Family"}, "IPR051994": {"description": "WW domain-binding", "go_ids": [], "go_terms": [], "name": "WW_domain-binding", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051995": {"description": "Ciliary function-associated GTPase", "go_ids": [], "go_terms": [], "name": "Ciliary_GTPase", "pathway_ids": ["R-HSA-9013409", "R-MMU-9646399", "R-HSA-9646399", "R-DRE-9013406", "R-DRE-9646399", "R-HSA-5624958", "R-MMU-5624958", "R-MMU-9013406", "R-CEL-9013406", "R-HSA-9613829", "R-HSA-9615710", "R-HSA-9013406", "R-CEL-9646399"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9646399:r:Aggrephagy", "R-HSA-9646399:r:Aggrephagy", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-DRE-9646399:r:Aggrephagy", "R-HSA-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-5624958:r:ARL13B-mediated ciliary trafficking of INPP5E", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-HSA-9615710:r:Late endosomal microautophagy", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-CEL-9646399:r:Aggrephagy"], "type": "Family"}, "IPR051996": {"description": "Plant Cytochrome P450 78A", "go_ids": [], "go_terms": [], "name": "Cytochrome_P450_78A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051997": {"description": "Serine/threonine-protein kinase NEK", "go_ids": [], "go_terms": [], "name": "STK_NEK", "pathway_ids": ["R-HSA-3301854", "R-MMU-2980767", "R-HSA-9648025", "R-HSA-2980767"], "pathways": ["R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7"], "type": "Family"}, "IPR051998": {"description": "Meteorin-like", "go_ids": [], "go_terms": [], "name": "Meteorin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR051999": {"description": "Mediator complex subunit 1", "go_ids": [], "go_terms": [], "name": "Mediator_complex_subunit_1", "pathway_ids": ["R-HSA-1989781", "R-HSA-2151201", "R-DME-383280", "R-DME-9018519", "R-DME-9707564", "R-HSA-381340", "R-HSA-9707616", "R-HSA-9931509", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-9018519", "R-HSA-383280", "R-MMU-383280", "R-DME-9841922", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-400206", "R-HSA-9833110", "R-MMU-400206", "R-DME-400206", "R-HSA-9018519", "R-HSA-212436", "R-MMU-9707564", "R-HSA-2426168"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-383280:r:Nuclear Receptor transcription pathway", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9707616:r:Heme signaling", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-383280:r:Nuclear Receptor transcription pathway", "R-MMU-383280:r:Nuclear Receptor transcription pathway", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9833110:r:RSV-host interactions", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-212436:r:Generic Transcription Pathway", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Family"}, "IPR052000": {"description": "Electron transfer flavoprotein regulatory factor 1", "go_ids": ["GO:0090324"], "go_terms": ["GO:0090324:negative regulation of oxidative phosphorylation:P"], "name": "ETFRF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052001": {"description": "MHC Class II Gamma Chain/Thyroglobulin", "go_ids": [], "go_terms": [], "name": "MHC-II_Gamma/Thyroglobulin", "pathway_ids": ["R-HSA-9925563", "R-RNO-2132295", "R-HSA-2132295", "R-RNO-202733", "R-MMU-202733", "R-MMU-2132295", "R-HSA-202733"], "pathways": ["R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-202733:r:Cell surface interactions at the vascular wall"], "type": "Family"}, "IPR052002": {"description": "Even-skipped homeobox domain-containing protein", "go_ids": [], "go_terms": [], "name": "Even-skipped_HD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052003": {"description": "Homologous Recombination DNA-Binding Protein", "go_ids": [], "go_terms": [], "name": "HR_DNA-Binding_Protein", "pathway_ids": ["R-HSA-5685942", "R-HSA-9704331", "R-HSA-5693579", "R-HSA-9704646", "R-MMU-5693568", "R-HSA-5693554", "R-MMU-5685942", "R-MMU-5693579", "R-HSA-9709603", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Family"}, "IPR052004": {"description": "Axonemal Dynein Assembly Factor 4", "go_ids": [], "go_terms": [], "name": "Dynein_assembly_factor_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052005": {"description": "Cation Diffusion Facilitator SLC30A", "go_ids": [], "go_terms": [], "name": "CDF_SLC30A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052006": {"description": "Major Latex-like", "go_ids": [], "go_terms": [], "name": "MLP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052007": {"description": "Bud site selection protein 4", "go_ids": [], "go_terms": [], "name": "Bud4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052008": {"description": "Mitochondrial ribosomal protein bL33", "go_ids": [], "go_terms": [], "name": "Mitoribosomal_protein_bL33", "pathway_ids": ["R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-MMU-5389840", "R-DME-9937383"], "pathways": ["R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control"], "type": "Family"}, "IPR052009": {"description": "Archaemetzincin", "go_ids": [], "go_terms": [], "name": "Archaemetzincin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052010": {"description": "Ribosomal Large Subunit bL36", "go_ids": [], "go_terms": [], "name": "Ribosomal_LSU_bL36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052011": {"description": "Centromere-associated NAC/CAD complex protein", "go_ids": [], "go_terms": [], "name": "CENP-NAC/CAD_complex", "pathway_ids": ["R-HSA-606279", "R-XTR-9648025", "R-RNO-68877", "R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-RNO-2500257", "R-RNO-606279", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-MMU-606279", "R-HSA-9648025", "R-XTR-68877", "R-MMU-68877", "R-RNO-5663220", "R-GGA-2500257", "R-GGA-141444", "R-XTR-141444", "R-XTR-606279", "R-HSA-68877", "R-GGA-9648025", "R-GGA-606279", "R-GGA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-HSA-5663220", "R-GGA-2467813", "R-MMU-9648025", "R-XTR-2500257", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-MMU-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-606279:r:Deposition of new CENPA-containing nucleosomes at the centromere", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Family"}, "IPR052012": {"description": "Glycosyltransferase_92", "go_ids": [], "go_terms": [], "name": "GTase_92", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR052013": {"description": "Mouse Killer cell lectin-like receptors", "go_ids": [], "go_terms": [], "name": "Mouse_KLRs", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052014": {"description": "Dictyostelium Tiger", "go_ids": [], "go_terms": [], "name": "Dictyostelium_Tiger", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052015": {"description": "Growth-differentiation transition regulator", "go_ids": [], "go_terms": [], "name": "GDT_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052016": {"description": "Bacterial Sigma Factor Regulator", "go_ids": [], "go_terms": [], "name": "Bact_Sigma-Reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052017": {"description": "4-Toluene Sulfonate Uptake Permease", "go_ids": [], "go_terms": [], "name": "TSUP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052018": {"description": "PHP domain-containing protein", "go_ids": [], "go_terms": [], "name": "PHP_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052019": {"description": "F420H(2)-dependent biliverdin reductase/Heme oxygenase", "go_ids": [], "go_terms": [], "name": "F420H2_bilvrd_red/Heme_oxyg", 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"R-RNO-5694530", "R-HSA-948021", "R-RNO-204005", "R-MMU-5694530"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-HSA-5694530:r:Cargo concentration in the ER", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-948021:r:Transport to the Golgi and subsequent modification", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-5694530:r:Cargo concentration in the ER"], "type": "Family"}, "IPR052111": {"description": "Spermatogenesis and Ciliary Microtubule-associated Protein", "go_ids": [], "go_terms": [], "name": "Spermatogenesis_Ciliary_MAP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052112": {"description": "EGFR Signaling Regulator Kinase", "go_ids": [], "go_terms": [], "name": "EGFR_SigReg_Kinase", "pathway_ids": ["R-RNO-9842663", "R-HSA-9842663", "R-MMU-9842663"], "pathways": ["R-RNO-9842663:r:Signaling by LTK", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-9842663:r:Signaling by LTK"], 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"R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-1566948:r:Elastic fibre formation", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-RNO-1566948:r:Elastic fibre formation"], "type": "Family"}, "IPR052236": {"description": "Small GTPase RasD", "go_ids": [], "go_terms": [], "name": "Small_GTPase_RasD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052237": {"description": "Ataxin-7-like transcription regulator", "go_ids": [], "go_terms": [], "name": "Ataxin-7-like_regulator", "pathway_ids": ["R-MMU-5689880", "R-HSA-3214847", "R-HSA-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-5689880:r:Ub-specific processing proteases"], "type": "Family"}, "IPR052239": {"description": "Serine/threonine-specific protein kinases", "go_ids": [], "go_terms": [], "name": "Ser/Thr-specific_kinases", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052240": {"description": "SAP domain-containing ribonucleoprotein", "go_ids": [], "go_terms": [], "name": "SAP_domain_ribonucleoprotein", "pathway_ids": ["R-RNO-73856", "R-HSA-73856", "R-RNO-159236", "R-HSA-159236", "R-MMU-73856", "R-HSA-72187", "R-MMU-72187", "R-MMU-159236"], "pathways": ["R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-MMU-72187:r:mRNA 3'-end processing", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript"], "type": "Family"}, "IPR052241": {"description": "Solute Carrier Family 66 (SLC66) and Scramblase ANY1", "go_ids": [], "go_terms": [], "name": "SLC66/Scramblase_ANY1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052242": {"description": "Mitochondrial 3-hydroxyacyl-CoA dehydrogenase", "go_ids": [], "go_terms": [], "name": "Mito_3-hydroxyacyl-CoA_DH", "pathway_ids": ["PWY-8182", "PWY-7007", "PWY-7401", "PWY-8354", "PWY-6435", "PWY-6443", "PWY-6583", "PWY-6946", "PWY-8181", "PWY-6945", "PWY-6458", "PWY-8152", "PWY-6944", "PWY-6863", "PWY-5789", "PWY-5136", "PWY-1361", "PWY-7778", "PWY-7216", "PWY-8347", "PWY-6883", "PWY-7094", "PWY-8179", "PWY-5177", "PWY-7779", "R-SSC-77352", "R-RNO-77352", "R-SSC-77348", "R-MMU-9837999", "R-RNO-77346", "R-CEL-9837999", "R-CEL-77348", "R-SSC-77350", "R-CEL-77350", "R-CEL-77352", "R-MMU-77350", "R-RNO-77310", "R-HSA-77350", "R-CEL-77310", "R-HSA-77348", "R-MMU-77348", "R-RNO-9837999", "R-HSA-77346", "R-MMU-77352", "R-SSC-77346", "R-SSC-77310", "R-MMU-77346", "R-RNO-77350", "R-HSA-77310", "R-MMU-77310", "R-RNO-77348", "R-SSC-9837999", "R-HSA-9837999", "R-HSA-77352", "R-CEL-77346"], 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(aerobic)", "PWY-7778:t:2-methylpropene degradation", "PWY-7216:t:(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)", "PWY-8347:t:adipate biosynthesis", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7094:t:fatty acid salvage", "PWY-8179:t:platensimycin biosynthesis", "PWY-5177:t:glutaryl-CoA degradation", "PWY-7779:t:methyl tert-butyl ether degradation", "R-SSC-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-RNO-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SSC-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-RNO-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-CEL-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-SSC-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-CEL-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-CEL-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-MMU-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-RNO-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-CEL-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-HSA-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-MMU-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-MMU-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-SSC-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-SSC-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "R-RNO-77350:r:Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "R-HSA-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-MMU-77310:r:Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "R-RNO-77348:r:Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "R-SSC-9837999:r:Mitochondrial protein degradation", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-HSA-77352:r:Beta oxidation of butanoyl-CoA to acetyl-CoA", "R-CEL-77346:r:Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "type": "Family"}, "IPR052243": {"description": "Mitochondrial inner membrane organizing protein", "go_ids": [], "go_terms": [], "name": "Mito_inner_membrane_organizer", "pathway_ids": ["R-HSA-8949613"], "pathways": ["R-HSA-8949613:r:Cristae formation"], "type": "Family"}, "IPR052244": {"description": "High-affinity choline transporter", "go_ids": [], "go_terms": [], "name": "Choline_transporter", "pathway_ids": ["R-HSA-9958517", "R-MMU-9958517", "R-RNO-264642", "R-CEL-9958517", "R-HSA-5658471", "R-RNO-9958517", "R-DME-9958517", "R-DME-264642", "R-HSA-264642", "R-CEL-264642", "R-HSA-5619114", "R-MMU-264642"], "pathways": ["R-HSA-9958517:r:SLC-mediated bile acid transport", "R-MMU-9958517:r:SLC-mediated bile acid transport", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-9958517:r:SLC-mediated bile acid transport", "R-HSA-5658471:r:Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "R-RNO-9958517:r:SLC-mediated bile acid transport", "R-DME-9958517:r:SLC-mediated bile acid transport", "R-DME-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-5619114:r:Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle"], "type": "Family"}, "IPR052245": {"description": "Plant Stress & Developmental Transcription Factors", "go_ids": [], "go_terms": [], "name": "Plant_Stress_Dev_TF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052246": {"description": "Cell Polarization and PKA Anchoring", "go_ids": [], "go_terms": [], "name": "Cell_Polariz_PKAAnc", "pathway_ids": ["R-HSA-983231", "R-CEL-983231", "R-SPO-983231", "R-MMU-983231", "R-SCE-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-CEL-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SPO-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Family"}, "IPR052247": {"description": "Meiotic Crossover Helicase", "go_ids": [], "go_terms": [], "name": "Meiotic_Crossover_Helicase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052248": {"description": "Arf-GAP domain and FG repeat-containing protein", "go_ids": [], "go_terms": [], "name": "Arf-GAP_FG-repeat_protein", "pathway_ids": ["R-RNO-8856828", "R-MMU-8856828", "R-RNO-8856825", "R-HSA-8856825", "R-HSA-8856828"], "pathways": ["R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis"], "type": "Family"}, "IPR052249": {"description": "Roquin domain-containing protein", "go_ids": [], "go_terms": [], "name": "Roquin_domain", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR052250": {"description": "Protein disulfide-isomerase TMX3", "go_ids": [], "go_terms": [], "name": "PDI_TMX3", "pathway_ids": ["R-HSA-114608", "R-SPO-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-SPO-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Family"}, "IPR052251": {"description": "Glycosyl Hydrolase and Zinc Finger 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"CUL4-DDB1_E3_ligase_receptor", "pathway_ids": ["R-SPO-8951664", "R-HSA-8951664", "R-CEL-8951664"], "pathways": ["R-SPO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-CEL-8951664:r:Neddylation"], "type": "Family"}, "IPR052255": {"description": "RNA polymerase II subunit 5-mediating protein", "go_ids": [], "go_terms": [], "name": "RNA_pol_II_subunit5-mediator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052256": {"description": "E3 ubiquitin-protein ligase CHFR", "go_ids": [], "go_terms": [], "name": "E3_ubiquitin-ligase_CHFR", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR052258": {"description": "Diverse Functionality Domain-containing Protein", "go_ids": [], "go_terms": [], "name": "Diverse_Func_Domain-Protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052259": {"description": "Nucleoredoxin-like", "go_ids": [], "go_terms": [], "name": "Nucleoredoxin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052260": {"description": "Autophagy Receptor and Signaling Regulator", "go_ids": [], "go_terms": [], "name": "Autophagy_Rcpt_SigReg", "pathway_ids": ["R-HSA-9020702", "R-RNO-9664873", "R-RNO-5205685", "R-RNO-9020702", "R-HSA-209560", "R-MMU-209543", "R-HSA-209543", "R-HSA-8951664", "R-RNO-9755511", "R-RNO-209560", "R-HSA-205043", "R-MMU-209560", "R-MMU-9020702", "R-HSA-9755511", "R-MMU-9755511", "R-MMU-5205685", "R-RNO-209543", "R-DME-9755511", "R-MMU-9664873", "R-DME-5205685", "R-RNO-205043", "R-DME-9664873", "R-HSA-9759194", "R-HSA-5205685", "R-MMU-205043", "R-HSA-9725370", "R-HSA-9664873"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9664873:r:Pexophagy", "R-RNO-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-8951664:r:Neddylation", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-MMU-9020702:r:Interleukin-1 signaling", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9664873:r:Pexophagy", "R-DME-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-DME-9664873:r:Pexophagy", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-5205685:r:PINK1-PRKN Mediated Mitophagy", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9664873:r:Pexophagy"], "type": "Family"}, "IPR052261": {"description": "Glycosyltransferase 13", "go_ids": [], "go_terms": [], "name": "Glycosyltransferase_13", "pathway_ids": ["PWY-7920", "PWY-7426", "R-CEL-964739", "R-RNO-964739", "R-HSA-9683686", "R-HSA-964739", "R-MMU-964739", "R-HSA-9694548"], "pathways": ["PWY-7920:t:complex N-linked glycan biosynthesis (plants)", "PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "R-CEL-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-RNO-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-HSA-9683686:r:Maturation of spike protein", "R-HSA-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-MMU-964739:r:N-glycan trimming and elongation in the cis-Golgi", "R-HSA-9694548:r:Maturation of spike protein"], "type": "Family"}, "IPR052262": {"description": "E2F-responsive SERTA domain-containing protein", "go_ids": [], "go_terms": [], "name": "E2F-SERTA_domain_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052263": {"description": "GPI Anchor 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"R-HSA-9013419", "R-CEL-9013425", "R-DRE-9013419", "R-DME-5689880", "R-MMU-9013419"], "pathways": ["R-DRE-5689880:r:Ub-specific processing proteases", "R-BTA-9013425:r:RHOT1 GTPase cycle", "R-CEL-9013419:r:RHOT2 GTPase cycle", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases", "R-DME-9013419:r:RHOT2 GTPase cycle", "R-RNO-9013419:r:RHOT2 GTPase cycle", "R-DME-9013425:r:RHOT1 GTPase cycle", "R-HSA-9013425:r:RHOT1 GTPase cycle", "R-GGA-9013419:r:RHOT2 GTPase cycle", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DRE-9013425:r:RHOT1 GTPase cycle", "R-HSA-5635838:r:Activation of SMO", "R-BTA-9013419:r:RHOT2 GTPase cycle", "R-XTR-9013419:r:RHOT2 GTPase cycle", "R-MMU-9013425:r:RHOT1 GTPase cycle", "R-HSA-9013419:r:RHOT2 GTPase cycle", "R-CEL-9013425:r:RHOT1 GTPase cycle", "R-DRE-9013419:r:RHOT2 GTPase cycle", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-9013419:r:RHOT2 GTPase cycle"], "type": "Family"}, "IPR052267": {"description": "Nexin-Dynein Regulatory Complex Component", "go_ids": [], "go_terms": [], "name": "N-DRC_Component", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052268": {"description": "Sterile alpha motif domain-containing protein", "go_ids": [], "go_terms": [], "name": "SAM_domain-containing_protein", "pathway_ids": ["R-DME-432553", "R-DME-209190", "R-DME-209214"], "pathways": ["R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-209190:r:Phosphorylation of CI", "R-DME-209214:r:Phosphorylation of SMO"], "type": "Family"}, "IPR052269": {"description": "Golgi apparatus maintenance and PI4KB interaction protein", "go_ids": [], "go_terms": [], "name": "Golgi-PI4KB_interaction", "pathway_ids": ["R-HSA-432722", "R-RNO-432722", "R-MMU-432722"], "pathways": ["R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Family"}, "IPR052270": {"description": "Centrosome-associated contractile fiber protein", "go_ids": [], "go_terms": [], "name": "CACF_protein", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-2565942", "R-MMU-8854518", "R-HSA-380284", "R-MMU-380270", "R-MMU-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Family"}, "IPR052271": {"description": "Glycerophosphoryl Diester Phosphodiesterase-Related", "go_ids": [], "go_terms": [], "name": "GDPD-Related", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978", "R-HSA-6814848"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I", "R-HSA-6814848:r:Glycerophospholipid catabolism"], "type": "Family"}, "IPR052272": {"description": "GT106 glycosyltransferase", "go_ids": [], "go_terms": [], "name": "GT106_glycosyltransferase", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR052273": {"description": "Peptidyl-prolyl cis-trans isomerase FKBP", "go_ids": [], "go_terms": [], "name": "PPIase_FKBP", "pathway_ids": ["R-HSA-381038"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes"], "type": "Family"}, "IPR052274": {"description": "Krueppel-type C2H2 zinc-finger", "go_ids": [], "go_terms": [], "name": "Krueppel_C2H2_Zn-finger", "pathway_ids": ["R-MMU-9013424", "R-HSA-9013424"], "pathways": ["R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle"], "type": "Family"}, "IPR052275": {"description": "Mitochondrial Fe-S cluster assembly factor", "go_ids": [], "go_terms": [], "name": "Mt_Fe-S_assembly_factor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052276": {"description": "Diphthamide biosynthesis and chaperone domain-containing protein", "go_ids": [], "go_terms": [], "name": "Diphthamide-biosynth_chaperone", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052277": {"description": "Inner Nuclear Membrane ESCRT-Associated Protein", "go_ids": [], "go_terms": [], "name": "INM_ESCRT-Associated", "pathway_ids": ["R-HSA-9013423", "R-HSA-9013405", "R-HSA-9013149", "R-HSA-4419969", "R-HSA-2980766", "R-HSA-9696270", "R-HSA-2995383", "R-HSA-9013408", "R-HSA-9668328", "R-HSA-9696273", "R-HSA-9696264", "R-HSA-9013404"], "pathways": ["R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-4419969:r:Depolymerization of the Nuclear Lamina", "R-HSA-2980766:r:Nuclear Envelope Breakdown", "R-HSA-9696270:r:RND2 GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9668328:r:Sealing of the nuclear envelope (NE) by ESCRT-III", "R-HSA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle"], "type": "Family"}, "IPR052278": {"description": "Chordin-like dorsalizing regulators", "go_ids": [], "go_terms": [], "name": "Chordin-like_regulators", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052279": {"description": "EngB GTPase", "go_ids": [], "go_terms": [], "name": "EngB_GTPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052280": {"description": "HEPACAM domain-containing protein", "go_ids": [], "go_terms": [], "name": "HEPACAM_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052281": {"description": "GRB2-associated and regulator of MAPK", "go_ids": [], "go_terms": [], "name": "GAREM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052282": {"description": "Starch-active lytic polysaccharide monooxygenase", "go_ids": [], "go_terms": [], "name": "Starch-active_LPMO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052283": {"description": "Genomic Stability and Neuronal Morphogenesis Regulator", "go_ids": [], "go_terms": [], "name": "GenomicStab_NeuMorph_Reg", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR052284": {"description": "Collagen-modifying leprecan protein", "go_ids": [], "go_terms": [], "name": "Collagen_mod_leprecan", "pathway_ids": ["R-MMU-1650814", "R-HSA-1650814"], "pathways": ["R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes"], "type": "Family"}, "IPR052285": {"description": "Nuclear exosome targeting complex subunit", "go_ids": [], "go_terms": [], "name": "NEXT_complex_subunit", "pathway_ids": ["R-DRE-9930044", "R-MMU-9930044", "R-HSA-72163", "R-HSA-9930044", "R-HSA-9843970", "R-MMU-72163", "R-BTA-9930044", "R-BTA-72163"], "pathways": ["R-DRE-9930044:r:Nuclear RNA decay", "R-MMU-9930044:r:Nuclear RNA decay", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-9930044:r:Nuclear RNA decay", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Family"}, "IPR052286": {"description": "Wnt/beta-catenin signaling inhibitor", "go_ids": [], "go_terms": [], "name": "Wnt_signaling_inhibitor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052287": {"description": "Non-homologous end-joining factor", "go_ids": [], "go_terms": [], "name": "NHEJ_factor", "pathway_ids": ["R-RNO-5693571", "R-MMU-5693571", "R-DRE-5693571", "R-HSA-5693571"], "pathways": ["R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Family"}, "IPR052288": {"description": "Glycosyl Hydrolase 45 Enzymes", "go_ids": [], "go_terms": [], "name": "GH45_Enzymes", "pathway_ids": ["PWY-6788"], "pathways": ["PWY-6788:t:cellulose degradation II (fungi)"], "type": "Family"}, "IPR052289": {"description": "Calcyclin-binding ubiquitin ligase bridge", "go_ids": [], "go_terms": [], "name": "Calcyclin-binding_UBL-bridge", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052290": {"description": "Sphingolipid C9-methyltransferase", "go_ids": [], "go_terms": [], "name": "Sphingo_C9-MT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052292": {"description": "Glucose repression regulatory protein", "go_ids": [], "go_terms": [], "name": "Glucose_repression_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052293": {"description": "Serine-Rich Repeat Protein (SRRP)", "go_ids": [], "go_terms": [], "name": "SRRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052294": {"description": "Visual system homeobox transcriptional regulators", "go_ids": [], "go_terms": [], "name": "VSX_homeobox_regulators", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052295": {"description": "Odorant-binding protein", "go_ids": [], "go_terms": [], "name": "Odorant-binding_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052296": {"description": "Transcriptional Repressor and Histone Methyltransferase", "go_ids": [], "go_terms": [], "name": "TR-Histone_Methyltrans", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-9762293"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-9762293:r:Regulation of CDH11 gene transcription"], "type": "Family"}, "IPR052297": {"description": "RING-CH-type E3 ubiquitin-protein ligase", "go_ids": [], "go_terms": [], "name": "RING-CH-type_E3_ubiq-ligase", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR052298": {"description": "Zinc finger MYND domain-containing protein 10", "go_ids": [], "go_terms": [], "name": "ZMYND10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052299": {"description": "Centrosomal protein of 76 kDa", "go_ids": [], "go_terms": [], "name": "CEP76", "pathway_ids": ["R-MMU-380259", "R-MMU-380270", "R-DRE-380320", "R-XTR-380270", "R-XTR-380284", "R-HSA-380284", "R-HSA-380270", "R-MMU-380284", "R-XTR-380320", "R-XTR-380259", "R-MMU-2565942", "R-MMU-380320", "R-HSA-8854518", "R-HSA-2565942", "R-HSA-380320", "R-XTR-5620912", "R-XTR-2565942", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-XTR-8854518"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2"], "type": "Family"}, "IPR052300": {"description": "Adhesion and Centrosome-associated Protein", "go_ids": [], "go_terms": [], "name": "Adhesion_Centrosome_assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052301": {"description": "SCF Complex F-box/Wd Repeat-Containing Protein", "go_ids": [], "go_terms": [], "name": "SCF_F-box/WD-repeat", "pathway_ids": ["R-MMU-8951664", "R-SCE-983168", "R-HSA-983168", "R-HSA-390471", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR052302": {"description": "Neurotrophin receptor-related death domain-containing protein", "go_ids": [], "go_terms": [], "name": "Neurotrophin_rcpt-DD", "pathway_ids": ["R-MMU-205017", "R-HSA-193648", "R-HSA-205017", "R-HSA-193670", "R-HSA-209560", "R-MMU-209560", "R-MMU-209543", "R-HSA-209543", "R-HSA-205043", "R-MMU-205043", "R-RNO-209560", "R-RNO-205025", "R-RNO-193634", "R-RNO-193692", "R-RNO-209563", "R-MMU-205025", "R-MMU-209563", "R-RNO-209543", "R-HSA-209563", "R-MMU-193692", "R-HSA-193681", "R-HSA-193634", "R-RNO-205043", "R-HSA-205025", "R-RNO-205017", "R-MMU-193634", "R-HSA-193692"], "pathways": ["R-MMU-205017:r:NFG and proNGF binds to p75NTR", "R-HSA-193648:r:NRAGE signals death through JNK", "R-HSA-205017:r:NFG and proNGF binds to p75NTR", "R-HSA-193670:r:p75NTR negatively regulates cell cycle via SC1", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-205043:r:NRIF signals cell death from the nucleus", "R-MMU-205043:r:NRIF signals cell death from the nucleus", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-RNO-205025:r:NADE modulates death signalling", "R-RNO-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-193692:r:Regulated proteolysis of p75NTR", "R-RNO-209563:r:Axonal growth stimulation", "R-MMU-205025:r:NADE modulates death signalling", "R-MMU-209563:r:Axonal growth stimulation", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-209563:r:Axonal growth stimulation", "R-MMU-193692:r:Regulated proteolysis of p75NTR", "R-HSA-193681:r:Ceramide signalling", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-RNO-205043:r:NRIF signals cell death from the nucleus", "R-HSA-205025:r:NADE modulates death signalling", "R-RNO-205017:r:NFG and proNGF binds to p75NTR", "R-MMU-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-193692:r:Regulated proteolysis of p75NTR"], "type": "Family"}, "IPR052303": {"description": "Cardiac-enriched FHL2-interacting", "go_ids": [], "go_terms": [], "name": "CEFIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052304": {"description": "Pituitary tumor-transforming gene 1 protein-interacting", "go_ids": [], "go_terms": [], "name": "PTTG1IP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052305": {"description": "Transcriptional Regulators and Tumor Expansion", "go_ids": [], "go_terms": [], "name": "TransReg_TumorExp", 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{"description": "E3 Ligase Complex Components and Neurotoxins", "go_ids": [], "go_terms": [], "name": "E3_Ligase-Neurotoxin", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation"], "type": "Family"}, "IPR052392": {"description": "Kelch repeat and BTB domain-containing protein", "go_ids": [], "go_terms": [], "name": "Kelch-BTB_domain-containing", "pathway_ids": ["R-MMU-8951664", "R-HSA-983168", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR052394": {"description": "Leucine-rich repeat-containing protein", "go_ids": [], "go_terms": [], "name": "LRR-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052395": {"description": "Electron Transfer Ferredoxin", 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"R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-HSA-8964038", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-RNO-5686938", "R-MMU-3000471", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-HSA-8957275", "R-RNO-3000480", "R-HSA-202733", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F 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(arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR052420": {"description": "Espin and Espin-like domain-containing protein", "go_ids": [], "go_terms": [], "name": "Espin/Espin-like", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Family"}, "IPR052421": {"description": "Plant Cell Wall Enzyme Inhibitor", "go_ids": [], "go_terms": [], "name": "PCW_Enzyme_Inhibitor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052422": {"description": "Auxin Signal Transduction Ser/Thr Kinase", "go_ids": [], "go_terms": [], "name": "Auxin_Ser/Thr_Kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052423": {"description": "Erythrocyte Membrane Invagination Regulator", "go_ids": [], "go_terms": [], "name": "EMIR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052424": {"description": "Kielin/Chordin-like & BMP-binding Regulator", "go_ids": [], "go_terms": [], "name": "Kielin_Chordin-BMP_Reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052425": {"description": "Uncharacterized MFS-type Transporter", "go_ids": [], "go_terms": [], "name": "Uncharacterized_MFS-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052426": {"description": "Plant developmental regulator", "go_ids": [], "go_terms": [], "name": "Plant_dev_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052427": {"description": "Glycosyltransferase family GT2 and GT47", "go_ids": [], "go_terms": [], "name": "Glycosyltrans_GT2/GT47", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-MMU-2022928", "R-HSA-2022928", "R-HSA-381038"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-381038:r:XBP1(S) activates chaperone genes"], "type": "Family"}, "IPR052428": {"description": "Autophagy and Host Defense Regulator", "go_ids": [], "go_terms": [], "name": "Autophagy_HostDef_Reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052429": {"description": "BAH domain-containing protein", "go_ids": [], "go_terms": [], "name": "BAH_domain_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052430": {"description": "Intracellular Vesicle Transport-Associated", "go_ids": [], "go_terms": [], "name": "IVT-Associated", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052431": {"description": "SKI2 subfamily ATP-dependent RNA helicases", "go_ids": [], "go_terms": [], "name": "SKI2_subfamily_helicases", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Family"}, "IPR052432": {"description": "Phosphatidylinositol transfer protein/CRAL-TRIO domain", "go_ids": [], "go_terms": [], "name": "PITP/CRAL-TRIO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052433": {"description": "Xaa-Pro dipeptidase-like", "go_ids": [], "go_terms": [], "name": "X-Pro_dipept-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052434": {"description": "Tectonic-like complex component protein", "go_ids": [], "go_terms": [], "name": "Tectonic-like_complex_comp", "pathway_ids": ["R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR052435": {"description": "YY1-Associated Transcriptional Regulator", "go_ids": [], "go_terms": [], "name": "YY1-Transcr_Regul", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052436": {"description": "LTO1 complex adapter protein", "go_ids": [], "go_terms": [], "name": "LTO1_adapter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052437": {"description": "Pectin Methylation Modulator", "go_ids": [], "go_terms": [], "name": "Pectin_Meth_Modulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052438": {"description": "Chromatin-remodeling and transcription coactivator", "go_ids": [], "go_terms": [], "name": "Chromatin_remod/trans_coact", "pathway_ids": ["R-HSA-9933947", "R-MMU-9933947"], "pathways": ["R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex"], "type": "Family"}, "IPR052439": {"description": "F-box/kelch-repeat domain-containing protein", "go_ids": [], "go_terms": [], "name": "F-box/Kelch-repeat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052440": {"description": "Transcriptional Regulator and Chromatin Remodeler", "go_ids": [], "go_terms": [], "name": "Trans_Reg/Chrom_Remod", "pathway_ids": ["R-HSA-9931509", "R-HSA-9707616"], "pathways": ["R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-9707616:r:Heme signaling"], "type": "Family"}, "IPR052441": {"description": "Armadillo Repeat & Ser/Thr Protein Kinase", "go_ids": [], "go_terms": [], "name": "Armadillo-Ser/Thr_Kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052442": {"description": "Environmental Response Regulator", "go_ids": [], "go_terms": [], "name": "Env_Response_Regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052443": {"description": "E3 ubiquitin-protein ligase RNF220-like", "go_ids": [], "go_terms": [], "name": "E3_ubiq-ligase_RNF220-like", "pathway_ids": ["PWY-7511", "R-HSA-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Family"}, "IPR052444": {"description": "Spaetzle/Toll ligand-like", "go_ids": [], "go_terms": [], "name": "Spz/Toll_ligand-like", "pathway_ids": ["R-DME-214842", "R-DME-214874", "R-DME-214844", "R-DME-214863", "R-DME-209442", "R-DME-214869", "R-DME-214862"], "pathways": ["R-DME-214842:r:DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'", "R-DME-214874:r:PLL kinase binds to TUB in the TL receptor 'signalling complex'", "R-DME-214844:r:DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'", "R-DME-214863:r:Adaptor protein complex binds to TL receptor at the plasma membrane", "R-DME-209442:r:Formation of the trans-membrane 'signalling complex'", "R-DME-214869:r:Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'", "R-DME-214862:r:Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"], "type": "Family"}, "IPR052445": {"description": "ZNF804A-like/GPATCH8", "go_ids": [], "go_terms": [], "name": "ZNF804A-like/GPATCH8", "pathway_ids": ["R-HSA-212436"], "pathways": ["R-HSA-212436:r:Generic Transcription Pathway"], "type": "Family"}, "IPR052446": {"description": "B-cell PI3K Activation and Signaling Adapters", "go_ids": [], "go_terms": [], "name": "B-cell_PI3K-Signaling_Adptrs", "pathway_ids": ["R-GGA-983695", "R-HSA-983695", "R-MMU-6811558", "R-GGA-6811558", "R-HSA-2219530", "R-HSA-1257604", "R-MMU-1257604", "R-MMU-983695", "R-GGA-1257604", "R-HSA-6811558"], "pathways": ["R-GGA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "type": "Family"}, "IPR052447": {"description": "Dermatan-Sulfate Isomerase", "go_ids": [], "go_terms": [], "name": "Dermatan-Sulfate_Isomerase", "pathway_ids": ["PWY-6568", "R-MMU-2022923", "R-HSA-2022923"], "pathways": ["PWY-6568:t:dermatan sulfate biosynthesis", "R-MMU-2022923:r:DS-GAG biosynthesis", "R-HSA-2022923:r:DS-GAG biosynthesis"], "type": "Family"}, "IPR052448": {"description": "DnaJ Homolog Subfamily C Member 16", "go_ids": [], "go_terms": [], "name": "DnaJ_C16_autophagy_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052449": {"description": "Serine/Threonine/Tyrosine-Interacting Phosphatase", "go_ids": [], "go_terms": [], "name": "STYX-Interacting_Phosphatase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052450": {"description": "Telomeric Repeat-Binding Domain-Containing Protein", "go_ids": [], "go_terms": [], "name": "TRBD-Containing_Protein", "pathway_ids": ["R-MMU-174430", "R-HSA-171306", "R-MMU-110330", "R-HSA-174414", "R-MMU-2559586", "R-MMU-174417", "R-HSA-174430", "R-HSA-110328", "R-HSA-1221632", "R-HSA-174411", "R-MMU-110331", "R-MMU-9670095", "R-HSA-171319", "R-MMU-171319", "R-HSA-110331", "R-HSA-174417", "R-MMU-174414", "R-HSA-9670095", "R-MMU-174437", "R-HSA-110329", "R-HSA-110330", "R-MMU-174411", "R-HSA-174437", "R-HSA-2559586"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-171306:r:Packaging Of Telomere Ends", "R-MMU-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-MMU-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-110328:r:Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-110331:r:Cleavage of the damaged purine", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase", "R-HSA-110331:r:Cleavage of the damaged purine", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-110329:r:Cleavage of the damaged pyrimidine", "R-HSA-110330:r:Recognition and association of DNA glycosylase with site containing an affected purine", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-2559586:r:DNA Damage/Telomere Stress Induced Senescence"], "type": "Family"}, "IPR052451": {"description": "Serine/threonine kinase-like", "go_ids": [], "go_terms": [], "name": "Ser/Thr_kinase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052452": {"description": "Ankyrin repeat and MYND domain-containing protein 2", "go_ids": [], "go_terms": [], "name": "Ankyrin-MYND_dom_contain_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052453": {"description": "CONSTANS-like zinc finger regulators", "go_ids": [], "go_terms": [], "name": "CONSTANS-like_ZF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052454": {"description": "Thioredoxin-related transmembrane domain-containing protein", "go_ids": [], "go_terms": [], "name": "TMX_domain-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052455": {"description": "Tricalbin domain-containing protein", "go_ids": [], "go_terms": [], "name": "Tricalbin_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052456": {"description": "CTLH complex component protein", "go_ids": [], "go_terms": [], "name": "CTLH_complex_component", "pathway_ids": ["R-RNO-9861718", "R-HSA-9861718", "R-MMU-9861718"], "pathways": ["R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-MMU-9861718:r:Regulation of pyruvate metabolism"], "type": "Family"}, "IPR052457": {"description": "Ankyrin repeat and death domain-containing protein", "go_ids": [], "go_terms": [], "name": "Ankyrin-DD_containing_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052458": {"description": "Polycomb group PRC1-like complex component", "go_ids": [], "go_terms": [], "name": "PcG_PRC1-like_component", "pathway_ids": ["R-HSA-4655427", "R-DME-8939243", "R-HSA-3108214", "R-HSA-2559580", "R-MMU-3899300", "R-MMU-4570464", "R-MMU-8939243", "R-DME-3108214", "R-MMU-8943724", "R-DME-2559580", "R-MMU-4551638", "R-HSA-8939243", "R-DME-4570464", "R-HSA-8943724", "R-DME-3899300", "R-HSA-4570464", "R-MMU-3108214", "R-HSA-3899300", "R-HSA-4551638", "R-DME-8943724"], "pathways": ["R-HSA-4655427:r:SUMOylation of DNA methylation proteins", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-DME-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DME-8943724:r:Regulation of PTEN gene transcription"], "type": "Family"}, "IPR052459": {"description": "Tumor necrosis factor receptor superfamily decoy receptor", "go_ids": [], "go_terms": [], "name": "TNFRSF_decoy_receptor", "pathway_ids": ["R-RNO-5669034", "R-HSA-5669034", "R-MMU-5669034", "R-BTA-5669034"], "pathways": ["R-RNO-5669034:r:TNFs bind their physiological receptors", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-BTA-5669034:r:TNFs bind their physiological receptors"], "type": "Family"}, "IPR052460": {"description": "Endoplasmic reticulum disulfide reductase", "go_ids": [], "go_terms": [], "name": "ER_disulfide_reductase", "pathway_ids": ["R-HSA-9918432"], "pathways": ["R-HSA-9918432:r:Maturation of DENV proteins"], "type": "Family"}, "IPR052461": {"description": "EVA1 A/B", "go_ids": [], "go_terms": [], "name": "EVA1_A/B", "pathway_ids": ["R-HSA-8957275", "R-HSA-381426"], "pathways": ["R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Family"}, "IPR052462": {"description": "SRA stem-loop-interacting RNA-binding protein/Glycine-rich RNA-binding-like", "go_ids": [], "go_terms": [], "name": "SLIRP/GR-RBP-like", "pathway_ids": ["R-HSA-9937008", "R-HSA-9836573"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Family"}, "IPR052463": {"description": "O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase", "go_ids": [], "go_terms": [], "name": "O-linked_mannose_GnT", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "R-HSA-8932506", "R-RNO-8932506", "R-MMU-8932504", "R-MMU-9939291", "R-HSA-8932504", "R-RNO-8932504", "R-HSA-9939291", "R-HSA-5083628", "R-RNO-9939291", "R-MMU-8932506"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen 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"Tubulin-tyrosine_ligase", "pathway_ids": ["R-HSA-8955332"], "pathways": ["R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Family"}, "IPR052493": {"description": "Tumor necrosis factor receptor superfamily member 1A", "go_ids": [], "go_terms": [], "name": "TNFRSF1A", "pathway_ids": ["R-MMU-5357786", "R-HSA-5626978", "R-HSA-5669034", "R-RNO-5357905", "R-HSA-75893", "R-MMU-5357956", "R-HSA-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-RNO-5626978", "R-MMU-5357905", "R-RNO-75893", "R-RNO-5357956", "R-MMU-5669034", "R-MMU-5626978", "R-RNO-5357786", "R-HSA-6783783", "R-RNO-5669034", "R-MMU-75893"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5626978:r:TNFR1-mediated ceramide production", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-75893:r:TNF signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-75893:r:TNF signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5669034:r:TNFs bind their physiological receptors", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-6783783:r:Interleukin-10 signaling", "R-RNO-5669034:r:TNFs bind their physiological receptors", "R-MMU-75893:r:TNF signaling"], "type": "Family"}, "IPR052494": {"description": "Flagella-assembly related protein", "go_ids": [], "go_terms": [], "name": "Flagella_assembly_related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052495": {"description": "Protein EARLY STARVATION 1-like", "go_ids": [], "go_terms": [], "name": "ESV1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052496": {"description": "Orphan Nuclear Receptor", "go_ids": [], "go_terms": [], "name": "Orphan_Nuclear_Rcpt", "pathway_ids": ["R-CEL-4090294", "R-CEL-383280", "R-CEL-9841922"], "pathways": ["R-CEL-4090294:r:SUMOylation of intracellular receptors", "R-CEL-383280:r:Nuclear Receptor transcription pathway", "R-CEL-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "type": "Family"}, "IPR052497": {"description": "H2.0 Homeobox Transcription Factors", "go_ids": [], "go_terms": [], "name": "H2.0_Homeobox_TF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052498": {"description": "E3 ubiquitin-protein ligase RNF138", "go_ids": [], "go_terms": [], "name": "E3_ubiq-protein_ligase_RNF138", "pathway_ids": ["R-BTA-983168", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168", "PWY-7511"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR052499": {"description": "Caenorhabditis elegans Nuclear Hormone Receptors", "go_ids": [], "go_terms": [], "name": "C.elegans_NHRs", "pathway_ids": ["R-CEL-383280"], "pathways": ["R-CEL-383280:r:Nuclear Receptor transcription pathway"], "type": "Family"}, "IPR052500": {"description": "Chloroplastic/Mitochondrial RNA Processing", "go_ids": [], "go_terms": [], "name": "Chloro/Mito_RNA_Process", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052501": {"description": "Alpha-1-2 Fucosyltransferase", "go_ids": [], "go_terms": [], "name": "Alpha-1-2_FucT", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR052502": {"description": "FAM241 domain-containing protein", "go_ids": [], "go_terms": [], "name": "FAM241_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052503": {"description": "S100-fused Epidermal Structural Protein", "go_ids": [], "go_terms": [], "name": "S100-fused_Epidermal_Struct", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-HSA-6809371", "R-HSA-9725554"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-6809371:r:Formation of the cornified envelope", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin"], "type": "Family"}, "IPR052504": {"description": "Mucin-related_signaling_and_protection_protein", "go_ids": [], "go_terms": [], "name": "Mucin_signaling_protection", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-HSA-977068", "R-DDI-937072", "R-DDI-937042", "R-DDI-450321", "R-DDI-9020702", "R-DDI-450302", "R-DDI-975163", "R-HSA-5083625", "R-HSA-5621480", "R-DDI-5689880", "R-HSA-913709"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-DDI-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-DDI-937042:r:IRAK2 mediated activation of TAK1 complex", "R-DDI-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DDI-9020702:r:Interleukin-1 signaling", "R-DDI-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DDI-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-HSA-5621480:r:Dectin-2 family", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Family"}, "IPR052505": {"description": "Fungal Pathogen Heme-Binding RBT5", "go_ids": [], "go_terms": [], "name": "Fungal_Heme-Binding_RBT5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052506": {"description": "Bacterial Fibronectin-Binding", "go_ids": [], "go_terms": [], "name": "Bact_Fn-Binding", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052507": {"description": "BPI fold-containing antibacterial protein", "go_ids": [], "go_terms": [], "name": "BPI_fold-antibacterial", "pathway_ids": ["R-MMU-6803157", "R-HSA-6803157", "R-RNO-6803157"], "pathways": ["R-MMU-6803157:r:Antimicrobial peptides", "R-HSA-6803157:r:Antimicrobial peptides", "R-RNO-6803157:r:Antimicrobial peptides"], "type": "Family"}, "IPR052508": {"description": "Maize Seed Storage Zein", "go_ids": [], "go_terms": [], "name": "Maize_Zein_Storage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052509": {"description": "Metal-responsive DNA-binding regulator", "go_ids": [], "go_terms": [], "name": "Metal_resp_DNA-bind_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052511": {"description": "ATP-dependent Helicase", "go_ids": [], "go_terms": [], "name": "ATP-dep_Helicase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052512": {"description": "4-carboxymuconolactone decarboxylase/NDH-1 regulator", "go_ids": [], "go_terms": [], "name": "4CMD/NDH-1_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052513": {"description": "Thioester Dehydratase-Related Protein", "go_ids": [], "go_terms": [], "name": "Thioester_dehydratase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052514": {"description": "S-adenosyl-L-methionine-dependent methyltransferase", "go_ids": [], "go_terms": [], "name": "SAM-dependent_MTase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR052515": {"description": "Gfo/Idh/MocA Oxidoreductase", "go_ids": [], "go_terms": [], "name": "Gfo/Idh/MocA_Oxidoreductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052516": {"description": "Nicotinate dehydrogenase subunit B-like", "go_ids": [], "go_terms": [], "name": "NicB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052517": {"description": "GlcG-related carbohydrate metabolism protein", "go_ids": [], "go_terms": [], "name": "GlcG_carb_metab_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052518": {"description": "Chromate transport protein", "go_ids": [], "go_terms": [], "name": "CHR_Transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052519": {"description": "Eukaryotic-type N-acetylglucosamine Kinase", "go_ids": [], "go_terms": [], "name": "Euk-type_GlcNAc_Kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052520": {"description": "Alkyltransferase-like DNA repair", "go_ids": [], "go_terms": [], "name": "ATL_DNA_repair", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052521": {"description": "Bacterial cell division SPOR domain-containing protein", "go_ids": [], "go_terms": [], "name": "Cell_div_SPOR-domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052522": {"description": "ABC-2 integral membrane transport permease", "go_ids": [], "go_terms": [], "name": "ABC-2_transport_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052523": {"description": "Trichothecene Biosynthesis Acetyltransferases", "go_ids": [], "go_terms": [], "name": "Trichothecene_AcTrans", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR052524": {"description": "Major Facilitator Superfamily Cyanate Porter", "go_ids": [], "go_terms": [], "name": "MFS_Cyanate_Porter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052526": {"description": "HTH-type transcriptional regulator MT0903-like", "go_ids": [], "go_terms": [], "name": "MT0903-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052527": {"description": "Heavy metal cation-efflux system component", "go_ids": [], "go_terms": [], "name": "Metal_cation-efflux_comp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052528": {"description": "Putative sugar transporter and related proteins", "go_ids": [], "go_terms": [], "name": "Sugar_transport-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052529": {"description": "Bacterial Transport-Associated Protein", "go_ids": [], "go_terms": [], "name": "Bact_Transport_Assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052531": {"description": "CarD-like transcription regulator", "go_ids": [], "go_terms": [], "name": "CarD-like_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052532": {"description": "Threonylcarbamoyl-AMP synthase YciO", "go_ids": [], "go_terms": [], "name": "YciO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052533": {"description": "Exodeoxyribonuclease WalJ/YycJ-like", "go_ids": ["GO:0004527"], "go_terms": ["GO:0004527:exonuclease activity:F"], "name": "WalJ/YycJ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052534": {"description": "Extracellular DNA Utilization and Secretion System Component", "go_ids": [], "go_terms": [], "name": "Extracell_DNA_Util/SecSys_Comp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052535": {"description": "Bacilysin biosynthesis H2HPP isomerase", "go_ids": [], "go_terms": [], "name": "Bacilysin_H2HPP_isomerase", "pathway_ids": ["PWY-7626"], "pathways": ["PWY-7626:t:bacilysin biosynthesis"], "type": "Family"}, "IPR052536": {"description": "ABC-4 Integral Membrane", "go_ids": [], "go_terms": [], "name": "ABC-4_Integral_Memb_Prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052537": {"description": "Extradiol ring-cleavage dioxygenase", "go_ids": [], "go_terms": [], "name": "Extradiol_RC_dioxygenase", "pathway_ids": ["PWY-6069", "PWY-5642", "PWY-6339", "PWY-6094", "PWY-7557", "PWY-6089", "PWY-8019", "PWY-7734", "PWY-7682", "PWY-6193", "PWY-5163", "PWY-8362", "PWY-6102", "PWY-8363", "PWY-6093", "PWY-6068", "PWY-6667", "PWY-8407", "PWY-8432", "PWY-7006", "PWY-6178", "PWY-7733", "PWY-7010", "PWY-7582", "PWY-6084", "PWY-6087", "PWY-181", "PWY-7009", "PWY-6107", "PWY-7011", "PWY-8431", "PWY-8260", "PWY-721", "PWY-6190", "PWY-8397", "PWY-8269", "PWY-6336"], "pathways": ["PWY-6069:t:indigo biosynthesis", "PWY-5642:t:2,4-dinitrotoluene degradation", "PWY-6339:t:syringate degradation", "PWY-6094:t:3,4,6-trichlorocatechol degradation", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-6089:t:3-chlorocatechol degradation I (ortho)", "PWY-8019:t:2-hydroxyparaconate and itatartarate biosynthesis", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7682:t:arabidopyrone biosynthesis", "PWY-6193:t:3-chlorocatechol degradation II (ortho)", "PWY-5163:t:p-cumate degradation to 2-hydroxypentadienoate", "PWY-8362:t:photorespiration II", "PWY-6102:t:5-chloro-3-methyl-catechol degradation", "PWY-8363:t:photorespiration III", "PWY-6093:t:4,5-dichlorocatechol degradation", "PWY-6068:t:indican biosynthesis", "PWY-6667:t:resveratrol degradation", "PWY-8407:t:fumagillin biosynthesis", "PWY-8432:t:4-hydroxypyridine degradation", "PWY-7006:t:4-amino-3-hydroxybenzoate degradation", "PWY-6178:t:2,4,6-trichlorophenol degradation", "PWY-7733:t:3-hydroxyquinaldate biosynthesis", "PWY-7010:t:2-propylphenol degradation", "PWY-7582:t:mercaptosuccinate degradation", "PWY-6084:t:3,5-dichlorocatechol degradation", "PWY-6087:t:4-chlorocatechol degradation", "PWY-181:t:photorespiration I", "PWY-7009:t:2,2'-dihydroxybiphenyl degradation", "PWY-6107:t:chlorosalicylate degradation", "PWY-7011:t:2-isopropylphenol degradation", "PWY-8431:t:L-mimosine degradation", "PWY-8260:t:roxarsone degradation I", "PWY-721:t:3-methylquinoline degradation", "PWY-6190:t:2,4-dichlorotoluene degradation", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-8269:t:methylarsonous acid detoxification III", "PWY-6336:t:protocatechuate degradation III (para-cleavage pathway)"], "type": "Family"}, "IPR052538": {"description": "Flavonoid dioxygenase-like", "go_ids": [], "go_terms": [], "name": "Flavonoid_dioxygenase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052539": {"description": "Molybdopterin-guanine dinucleotide biosynthesis adapter", "go_ids": [], "go_terms": [], "name": "MGD_biosynthesis_adapter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052541": {"description": "Sulfide-quinone oxidoreductase", "go_ids": [], "go_terms": [], "name": "SQRD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052542": {"description": "Cholesterol Oxidase Enzyme", "go_ids": [], "go_terms": [], "name": "Cholesterol_Oxidase", "pathway_ids": ["PWY-6945", "PWY-2582", "PWY-7299", "PWY-6948", "PWY-8200", "PWY-8202", "PWY-699", "PWY-8151", "PWY-6946"], "pathways": ["PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-2582:t:brassinolide biosynthesis II", "PWY-7299:t:progesterone biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-8200:t:backdoor pathway of androgen biosynthesis", "PWY-8202:t:11-oxyandrogens biosynthesis", "PWY-699:t:brassinolide biosynthesis I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)"], "type": "Family"}, "IPR052543": {"description": "HTH-type Metal-responsive Transcriptional Regulator", "go_ids": [], "go_terms": [], "name": "HTH_Metal-responsive_Reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052544": {"description": "Bacteriocin Processing Enzyme", "go_ids": [], "go_terms": [], "name": "Bacteriocin_Proc_Enz", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052546": {"description": "Transposase_8_domain-containing_protein", "go_ids": [], "go_terms": [], "name": "Transposase_8_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052547": {"description": "Mitochondrial Isobutyryl-CoA Dehydrogenase", "go_ids": [], "go_terms": [], "name": "Mito_Isobutyryl-CoADH", "pathway_ids": ["PWY-8182", "PWY-5109", "PWY-8181", "R-DDI-70895", "R-DDI-9837999", "R-BTA-70895", "R-HSA-9837999", "R-MMU-9837999", "R-HSA-70895", "R-MMU-70895", "R-BTA-9837999"], "pathways": ["PWY-8182:t:valproate beta-oxidation", "PWY-5109:t:propanoate fermentation to 2-methylbutanoate", "PWY-8181:t:2-methyl-branched fatty acid beta-oxidation", "R-DDI-70895:r:Branched-chain amino acid catabolism", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-HSA-70895:r:Branched-chain amino acid catabolism", "R-MMU-70895:r:Branched-chain amino acid catabolism", "R-BTA-9837999:r:Mitochondrial protein degradation"], "type": "Family"}, "IPR052548": {"description": "Type VII toxin-antitoxin system antitoxin", "go_ids": [], "go_terms": [], "name": "Type_VII_TA_antitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052549": {"description": "Spore maturation protein B", "go_ids": [], "go_terms": [], "name": "SpmB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052550": {"description": "Pyrimidine 5'-nucleotidase YjjG", "go_ids": [], "go_terms": [], "name": "Pyrimidine_5'-ntase_YjjG", "pathway_ids": ["PWY-7821", "PWY-7185", "PWY-5381", "PWY-6596", "PWY-5695", "PWY-6607", "PWY-6608", "PWY-6606"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-5381:t:NAD salvage (plants)", "PWY-6596:t:adenosine nucleotides degradation I", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II"], "type": "Family"}, "IPR052551": {"description": "UV-induced DNA damage repair photolyase", "go_ids": [], "go_terms": [], "name": "UV-DNA_repair_photolyase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052552": {"description": "YeaO-like", "go_ids": [], "go_terms": [], "name": "YeaO-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052553": {"description": "Cobalt-precorrin-5A hydrolase", "go_ids": [], "go_terms": [], "name": "CbiG_hydrolase", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Family"}, "IPR052554": {"description": "2-oxoglutarate synthase subunit KorC", "go_ids": [], "go_terms": [], "name": "2-oxoglutarate_synth_KorC", "pathway_ids": ["PWY-5392", "PWY-6969", "PWY-7254"], "pathways": ["PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)", "PWY-7254:t:TCA cycle VII (acetate-producers)"], "type": "Family"}, "IPR052555": {"description": "dCTP Pyrophosphatase", "go_ids": [], "go_terms": [], "name": "dCTP_Pyrophosphatase", "pathway_ids": ["R-HSA-499943"], "pathways": ["R-HSA-499943:r:Interconversion of nucleotide di- and triphosphates"], "type": "Family"}, "IPR052556": {"description": "Polysaccharide Synthase/Transporter", "go_ids": [], "go_terms": [], "name": "PolySynth_Transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052557": {"description": "Cytoskeleton-associated protease/Cytokinesis protein", "go_ids": [], "go_terms": [], "name": "CAP/Cytokinesis_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052558": {"description": "Siderophore Hydrolyzing Esterase D", "go_ids": [], "go_terms": [], "name": "Siderophore_Hydrolase_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052559": {"description": "Vanadium-dependent haloperoxidase", "go_ids": [], "go_terms": [], "name": "V-haloperoxidase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052560": {"description": "RNA-directed DNA polymerase, mobile element", "go_ids": [], "go_terms": [], "name": "RdDP_mobile_element", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052561": {"description": "Complex I Subunit 1", "go_ids": [], "go_terms": [], "name": "ComplexI_Subunit1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052562": {"description": "Ketohexokinase-related", "go_ids": [], "go_terms": [], "name": "Ketohexokinase-related", "pathway_ids": ["PWY-8404", "R-HSA-5657562", "R-HSA-70350", "R-RNO-70350", "R-MMU-70350"], "pathways": ["PWY-8404:t:glycolysis VI (from fructose)", "R-HSA-5657562:r:Essential fructosuria", "R-HSA-70350:r:Fructose catabolism", "R-RNO-70350:r:Fructose catabolism", "R-MMU-70350:r:Fructose catabolism"], "type": "Family"}, "IPR052563": {"description": "Flagellar hook-length control", "go_ids": [], "go_terms": [], "name": "FliK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052565": {"description": "Glutaredoxin-like YDR286C", "go_ids": [], "go_terms": [], "name": "Glutaredoxin-like_YDR286C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052566": {"description": "Non-lysosomal glucosylceramidase", "go_ids": [], "go_terms": [], "name": "Non-lysos_glucosylceramidase", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-6848", "PWY-7487", "PWY-6655", "PWY-7940", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-8436", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-5976", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7057", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-7529", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-7091", "PWY-1901", "PWY-8241", "PWY-7745", "PWY-7055", "PWY-6527", "PWY-5139", "PWY-7143", "PWY-7647", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-6821", "PWY-5339", "PWY-6735", "PWY-5310", "PWY-6855", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-862", "PWY-6737", "PWY-7445", "PWY-5821", "PWY-8379", "PWY-6749", "PWY-7463", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-7134", "PWY-7133", "PWY-1921", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-6784", "PWY-7838", "PWY-7960", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-6717", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-6906", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-8435", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-7074", "PWY-8272", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8366", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-842", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-7056", "PWY-7256", "PWY-5400", "PWY-7697", "R-MMU-9840310", "R-RNO-9840310", "R-HSA-9840310", "R-DME-9840310"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-6848:t:rutin degradation", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-8436:t:mammalian high-mannose N-glycan degradation", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-5976:t:dhurrin degradation", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7057:t:cichoriin interconversion", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-7091:t:linustatin bioactivation", "PWY-1901:t:aurone biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-6527:t:stachyose degradation", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-7647:t:ulvan degradation", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-6821:t:kappa-carrageenan degradation", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-6735:t:starch degradation IV", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-6855:t:chitin degradation I (archaea)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-862:t:fructan degradation", "PWY-6737:t:starch degradation V", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-5821:t:dalcochinin biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7134:t:rutin degradation (plants)", "PWY-7133:t:quercetin glucoside degradation (Allium)", "PWY-1921:t:indole-3-acetate activation II", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-6784:t:cellulose and hemicellulose degradation (cellulolosome)", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-7960:t:rhabduscin biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-6717:t:(1,4)-beta-D-xylan degradation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-6906:t:chitin derivatives degradation", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-8435:t:yeast mannan degradation", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-842:t:starch degradation I", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7056:t:daphnin interconversion", "PWY-7256:t:cyanidin diglucoside biosynthesis (acyl-glucose dependent)", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-DME-9840310:r:Glycosphingolipid catabolism"], "type": "Family"}, "IPR052567": {"description": "Hydroxymethylphosphonate dioxygenase-like", "go_ids": [], "go_terms": [], "name": "PhnZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052568": {"description": "Polyketide Synthase and Fatty Acid Synthase", "go_ids": [], "go_terms": [], "name": "PKS-FAS_Synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052570": {"description": "Flagellar FliJ", "go_ids": [], "go_terms": [], "name": "FliJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052571": {"description": "Mitochondrial RNA Methyltransferase", "go_ids": [], "go_terms": [], "name": "Mt_RNA_Methyltransferase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052572": {"description": "UPF0153 domain-containing protein", "go_ids": [], "go_terms": [], "name": "UPF0153_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052573": {"description": "DnaJ homolog subfamily C member 28", "go_ids": [], "go_terms": [], "name": "DnaJ_C_subfamily_28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052574": {"description": "Cell Division and Infection-Related Protein", "go_ids": [], "go_terms": [], "name": "CDIRP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052575": {"description": "Small subunit processome component 20", "go_ids": [], "go_terms": [], "name": "SSU_processome_comp_20", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR052576": {"description": "Amino Acid Transporter-Related", "go_ids": [], "go_terms": [], "name": "AA_Transporter-Related", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052577": {"description": "VWA7", "go_ids": [], "go_terms": [], "name": "VWA7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052578": {"description": "Phosphatidylinositol Transfer CRAL-TRIO Domain-Containing Protein", "go_ids": [], "go_terms": [], "name": "PI_Transfer_CRAL-TRIO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052579": {"description": "Zinc finger SWIM domain-containing protein", "go_ids": [], "go_terms": [], "name": "Zinc_finger_SWIM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052580": {"description": "Probable Lipid Hydrolase", "go_ids": [], "go_terms": [], "name": "Lipid_Hydrolase", "pathway_ids": ["PWY-6848", "PWY-6322", "PWY-6339", "PWY-7769", "PWY-7367", "PWY-1921", "PWY-6558", "PWY-8391", "PWY-8390", "PWY-6308", "PWY-7660", "PWY-8058", "PWY-8384", "PWY-7002", "PWY-7713", "PWY-7599", "PWY-8455", "PWY-7352", "PWY-6415", "PWY-8247", "PWY-7730", "PWY-5835", "PWY-7982", "PWY-7712", "PWY-6190", "PWY-8143", "PWY-7521"], "pathways": ["PWY-6848:t:rutin degradation", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6339:t:syringate degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7367:t:phosphatidylcholine resynthesis via glycerophosphocholine", "PWY-1921:t:indole-3-acetate activation II", "PWY-6558:t:heparan sulfate biosynthesis", 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"R-RNO-9696270:r:RND2 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-170984:r:ARMS-mediated activation", "R-DRE-9696270:r:RND2 GTPase cycle", "R-HSA-170984:r:ARMS-mediated activation", "R-DRE-170984:r:ARMS-mediated activation"], "type": "Family"}, "IPR052772": {"description": "Endonuclease/Polynucleotide Kinase Domain-Containing Protein", "go_ids": [], "go_terms": [], "name": "Endo/PolyKinase_Domain-Protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052773": {"description": "Anaerobic Bacterial Peroxidase-Related", "go_ids": [], "go_terms": [], "name": "Anaerobic_Peroxidase-Rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052774": {"description": "C. elegans Developmental and Neuronal Protein", "go_ids": [], "go_terms": [], "name": "Celegans_DevNeuronal_Protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052775": {"description": "Inosine-uridine nucleoside hydrolase", "go_ids": [], "go_terms": [], "name": "IUN_hydrolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052776": {"description": "Chloroplast-associated Reproductive Support & Metal Ion Transport", "go_ids": [], "go_terms": [], "name": "Chloro_ReproSupport/MetalTrans", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052777": {"description": "Acetyltransferase Enzymes", "go_ids": [], "go_terms": [], "name": "Acetyltransferase_Enz", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR052778": {"description": "Centrosome-associated WD domain-containing protein", "go_ids": [], "go_terms": [], "name": "Centrosome-WD_assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052779": {"description": "WD repeat-containing protein 62", "go_ids": [], "go_terms": [], "name": "WDR62", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052780": {"description": "Aromatic Amino Acid Catabolism Transcriptional Regulators", "go_ids": [], "go_terms": [], "name": "AAA_Catabolism_Regulators", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052781": {"description": "Cysteine protease inhibitor I42", "go_ids": [], "go_terms": [], "name": "Cys_protease_inhibitor_I42", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052782": {"description": "Oocyte-to-zygote transition regulator", "go_ids": [], "go_terms": [], "name": "Oocyte-zygote_transition_reg", "pathway_ids": ["R-CEL-5675221"], "pathways": ["R-CEL-5675221:r:Negative regulation of MAPK pathway"], "type": "Family"}, "IPR052784": {"description": "Perforin-1 pore-forming", "go_ids": [], "go_terms": [], "name": "Perforin-1_pore-forming", "pathway_ids": ["R-HSA-9725371"], "pathways": ["R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer"], "type": "Family"}, "IPR052785": {"description": "Enterotoxin complex component", "go_ids": [], "go_terms": [], "name": "Enterotoxin_cmpnt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052786": {"description": "Outer_spore_wall_assembly", "go_ids": [], "go_terms": [], "name": "Spore_wall_assembly", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052787": {"description": "Mitochondrial antiviral-signaling domain-containing protein", "go_ids": [], "go_terms": [], "name": "MAVS", "pathway_ids": ["R-HSA-9833109", "R-HSA-918233", "R-MMU-9833482", "R-HSA-933541", "R-MMU-168928", "R-HSA-9705671", "R-HSA-9920588", "R-HSA-9833482", "R-HSA-5689896", "R-RNO-936440", "R-HSA-933543", "R-HSA-168928", "R-HSA-933542", "R-HSA-9692916", "R-MMU-936440", "R-HSA-936440", "R-RNO-168928", "R-RNO-9833482"], "pathways": ["R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-MMU-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-9833482:r:PKR-mediated signaling", "R-HSA-5689896:r:Ovarian tumor domain proteases", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-RNO-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-RNO-9833482:r:PKR-mediated signaling"], "type": "Family"}, "IPR052788": {"description": "RING-type E3 ubiquitin ligase ATL", "go_ids": [], "go_terms": [], "name": "RING-type_E3_ligase_ATL", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Family"}, "IPR052789": {"description": "Protein SSUH2 homolog", "go_ids": [], "go_terms": [], "name": "SSUH2_homolog", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052790": {"description": "YEATS domain-containing", "go_ids": [], "go_terms": [], "name": "YEATS_domain", "pathway_ids": ["R-HSA-674695", "R-HSA-112382", "R-HSA-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Family"}, "IPR052791": {"description": "SSM1 domain-containing protein", "go_ids": [], "go_terms": [], "name": "SSM1_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052792": {"description": "Thioredoxin domain-containing protein 11", "go_ids": [], "go_terms": [], "name": "Thioredoxin_dom-contain_11", "pathway_ids": ["R-HSA-209968", "R-MMU-209968"], "pathways": ["R-HSA-209968:r:Thyroxine biosynthesis", "R-MMU-209968:r:Thyroxine biosynthesis"], "type": "Family"}, "IPR052793": {"description": "Exon junction complex-associated protein", "go_ids": [], "go_terms": [], "name": "EJC-associated_protein", "pathway_ids": ["R-MMU-111465", "R-HSA-72163", "R-MMU-72163", "R-HSA-111465"], "pathways": ["R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins"], "type": "Family"}, "IPR052794": {"description": "Mitochondrial Serine Protease LACTB", "go_ids": [], "go_terms": [], "name": "Mito_Ser_Protease_LACTB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052795": {"description": "Ras-responsive element-binding protein 1", "go_ids": [], "go_terms": [], "name": "RREB1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052796": {"description": "Nodulation factor sulfotransferase", "go_ids": [], "go_terms": [], "name": "Nod_factor_sulfotransferase", "pathway_ids": ["PWY-8045", "PWY-7831", "PWY-8381", "PWY-6558", "PWY-6546", "PWY-6568", "PWY-6567", "PWY-8358"], "pathways": ["PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7831:t:ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide", "PWY-8381:t:sulfazecin biosynthesis", "PWY-6558:t:heparan sulfate biosynthesis", "PWY-6546:t:brassinosteroids inactivation", "PWY-6568:t:dermatan sulfate biosynthesis", "PWY-6567:t:chondroitin sulfate biosynthesis", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR052797": {"description": "Regulatory Factors in Gene Expression and Cell Death", "go_ids": [], "go_terms": [], "name": "RegFact_GeneExpr_CellDeath", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052798": {"description": "Giardia Variant Surface Antigen", "go_ids": [], "go_terms": [], "name": "Giardia_VSA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052799": {"description": "Rho GTPase-activating Regulators", "go_ids": [], "go_terms": [], "name": "Rho_GAP_Regulators", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052800": {"description": "DNA Repair Helicase ZGRF1", "go_ids": [], "go_terms": [], "name": "DNA_Repair_Helicase_ZGRF1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052801": {"description": "Ankyrin Repeat and EF-hand Domain-containing", "go_ids": [], "go_terms": [], "name": "Ankyrin-EF-hand", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052802": {"description": "Kinetochore-associated protein 1", "go_ids": [], "go_terms": [], "name": "KNTC1", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-5663220", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Family"}, "IPR052803": {"description": "Primary Cilium-Associated Jouberin", "go_ids": [], "go_terms": [], "name": "Cilium-Associated_Jouberin", "pathway_ids": ["R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912"], "pathways": ["R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Family"}, "IPR052804": {"description": "Ubiquitin-editing complex component", "go_ids": [], "go_terms": [], "name": "UEC_component", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052805": {"description": "GEF and Ubiquitin-Proteasome Regulators", "go_ids": [], "go_terms": [], "name": "GEF_Ubiquitin-Prot_Reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052806": {"description": "Fasciclin-like AGP", "go_ids": [], "go_terms": [], "name": "Fasciclin-like_AGP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052807": {"description": "Mitochondrial translation and respiration regulator", "go_ids": [], "go_terms": [], "name": "Mito_transl_resp_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052808": {"description": "G-protein coupled receptor Mth-like", "go_ids": [], "go_terms": [], "name": "GPCR_Mth-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052809": {"description": "Actin-polarity regulatory", "go_ids": [], "go_terms": [], "name": "Actin_polarity_regulatory", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052810": {"description": "Plant N-acetyltransferase", "go_ids": [], "go_terms": [], "name": "Plant_NAT", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester 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"R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II 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"PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR052833": {"description": "Telomeric DNA-binding and transcriptional regulator", "go_ids": [], "go_terms": [], "name": "Telomeric_DNA-bd_trans-reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052834": {"description": "3-Keto-Steroid Reductase/17-beta-Hydroxysteroid Dehydrogenase", "go_ids": [], "go_terms": [], "name": "3KSR/17beta-HSD", "pathway_ids": ["PWY-8191", "PWY-2541", "PWY-8238", "PWY-8200", "PWY-8239", "PWY-6074", "PWY-8026", "R-HSA-6807047", "R-MMU-6807047", "R-RNO-6807047", "R-HSA-6807062", "R-RNO-6807062", "R-MMU-6807062"], "pathways": ["PWY-8191:t:cholesterol biosynthesis (algae, late side-chain reductase)", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-8200:t:backdoor pathway of 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"go_ids": [], "go_terms": [], "name": "ER_body_metal_sequester", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052844": {"description": "Leaf Development Regulator", "go_ids": [], "go_terms": [], "name": "Leaf_Dev_Regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052845": {"description": "Axonemal dynein light chain domain-containing protein", "go_ids": [], "go_terms": [], "name": "Axonemal_dynein_LC_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052847": {"description": "Extended Synaptotagmin & KAHRP-like protein", "go_ids": [], "go_terms": [], "name": "Ext_Synaptotagmin/KAHRP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052848": {"description": "Coiled-coil-helix-coiled-coil-helix domain-containing protein", "go_ids": [], "go_terms": [], "name": "CHCH_domain-containing_protein", "pathway_ids": ["R-HSA-1268020"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import"], "type": "Family"}, "IPR052849": {"description": "MORN repeat-containing protein", "go_ids": [], "go_terms": [], "name": "MORN_repeat_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052850": {"description": "NPAT LisH domain-containing protein", "go_ids": [], "go_terms": [], "name": "NPAT_LisH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052851": {"description": "GAMETE CELL DEFECTIVE 1 mitochondrial", "go_ids": [], "go_terms": [], "name": "GCD1_mitochondrial", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052852": {"description": "SSU Processome Component", "go_ids": [], "go_terms": [], "name": "SSU_Processome_Comp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052853": {"description": "Actin dynamics regulator", "go_ids": [], "go_terms": [], "name": "Actin_dynamics_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR052854": {"description": "Nematode Serpentine Receptor Class Epsilon", "go_ids": [], "go_terms": [], "name": 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"TUNICAMYCIN_INDUCED_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053284": {"description": "RGS1-HXK1-interacting protein", "go_ids": [], "go_terms": [], "name": "RGS1-HXK1_interactor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053285": {"description": "Thylakoid lumenal pentapeptide repeat protein", "go_ids": [], "go_terms": [], "name": "Thylakoid_lumenal_pentapeptide", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053286": {"description": "Nematode receptor-like srab", "go_ids": [], "go_terms": [], "name": "Nematode_rcpt-like_srab", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053287": {"description": "PP2C-like domain-containing protein", "go_ids": [], "go_terms": [], "name": "PP2C-like_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053288": {"description": "TRIGALACTOSYLDIACYLGLYCEROL Bridge Protein", "go_ids": [], "go_terms": [], "name": "TGD_Bridge_Protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053290": {"description": "TSET complex member", "go_ids": [], "go_terms": [], "name": "TSET_complex_member", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053291": {"description": "Ommatidial differentiation-associated protein", "go_ids": [], "go_terms": [], "name": "Ommatidial_diff-associated", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053292": {"description": "UBAP1-MVB12-associated (UMA)-domain containing protein 1", "go_ids": [], "go_terms": [], "name": "UMAD1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053293": {"description": "Outer Chloroplast Membrane Kinase", "go_ids": [], "go_terms": [], "name": "OCM_Kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053294": {"description": "RNA-binding PWI domain-containing protein", "go_ids": [], "go_terms": [], "name": "RBM_PWI_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053295": {"description": "Innate immunity regulator", "go_ids": [], "go_terms": [], "name": "Innate_immunity_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053296": {"description": "TSET complex member tstB", "go_ids": [], "go_terms": [], "name": "TSET_member_tstB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053297": {"description": "Dynactin-associated protein", "go_ids": [], "go_terms": [], "name": "Dynactin-associated", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053298": {"description": "Sushi domain-containing protein", "go_ids": [], "go_terms": [], "name": "Sushi_domain_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053299": {"description": "ASTRA complex-associated WD repeat", "go_ids": [], "go_terms": [], "name": "ASTRA_WD_repeat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053300": {"description": "Homeobox-like transcriptional regulator", "go_ids": [], "go_terms": [], "name": "Homeobox-like_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053301": {"description": "F-box motif-containing protein", "go_ids": [], "go_terms": [], "name": "F-box_motif", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053302": {"description": "CRAL-TRIO domain-containing protein", "go_ids": [], "go_terms": [], "name": "CRAL-TRIO_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053303": {"description": "Chloroplast PPR-containing protein", "go_ids": [], "go_terms": [], "name": "Chloroplast_PPR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053304": {"description": "RNA M5U Methyltransferase", "go_ids": [], "go_terms": [], "name": "RNA_M5U_MTase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053305": {"description": "Folate-binding receptor-like", "go_ids": [], "go_terms": [], "name": "Folate-binding_rcpt-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053307": {"description": "Mitochondrial ATP-independent inner membrane protease", "go_ids": [], "go_terms": [], "name": "Mitochondrial_IM_protease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053308": {"description": "Vago-like", "go_ids": [], "go_terms": [], "name": "Vago-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053309": {"description": "Bucky ball", "go_ids": [], "go_terms": [], "name": "Bucky_ball", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053310": {"description": "Flavoredoxin-like", "go_ids": [], "go_terms": [], "name": "Flavoredoxin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053311": {"description": "Mucosal Integrity Associated", "go_ids": [], "go_terms": [], "name": "Mucosal_Integrity_Assoc", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-913709", "R-HSA-977068", "R-HSA-5083625"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC"], "type": "Family"}, "IPR053313": {"description": "Root Meristem Growth Factor", "go_ids": [], "go_terms": [], "name": "RGF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053315": {"description": "Peptidase C14A", "go_ids": [], "go_terms": [], "name": "Peptidase_C14A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053316": {"description": "Epigenetic regulator of gene expression", "go_ids": [], "go_terms": [], "name": "Epigenetic_reg_gene_expr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053317": {"description": "Tubulin polyglutamylase", "go_ids": [], "go_terms": [], "name": "Tubulin_polyglutamylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053318": {"description": "Glycosyltransferase 64", "go_ids": [], "go_terms": [], "name": "GT64", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053319": {"description": "Outer envelope protein 61", "go_ids": [], "go_terms": [], "name": "OEP61", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053320": {"description": "Protein DD3-3 O-glycosylation", "go_ids": [], "go_terms": [], "name": "Protein_DD3-3_O-glyco", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053321": {"description": "Inositol Polyphosphate 5-Phosphatase Type IV", "go_ids": [], "go_terms": [], "name": "IPP-5-Phosphatase_Type_IV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053322": {"description": "Phospholipase A2-like", "go_ids": [], "go_terms": [], "name": "PLA2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053323": {"description": "UPF0235 domain-containing protein", "go_ids": [], "go_terms": [], "name": "UPF0235", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053324": {"description": "Hydrophobic Surface Structural Protein", "go_ids": [], "go_terms": [], "name": "Hydrophobic_Surface_Structural", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053325": {"description": "Histone H3 Acetylation Activator", "go_ids": [], "go_terms": [], "name": "H3-Acetyl_Activator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053326": {"description": "G-protein coupled receptor 1-like", "go_ids": [], "go_terms": [], "name": "GPCR1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053327": {"description": "Kinase-Interacting Protein", "go_ids": [], "go_terms": [], "name": "KIP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053328": {"description": "Uro-adherence factor A-like", "go_ids": [], "go_terms": [], "name": "Uro-adherence_factor_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053329": {"description": "Merozoite Surface-Associated Protein", "go_ids": [], "go_terms": [], "name": "Merozoite_Surface_Assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053330": {"description": "Mucin-22-like", "go_ids": [], "go_terms": [], "name": "Mucin-22-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053331": {"description": "EGF-like domain-containing protein comC", "go_ids": [], "go_terms": [], "name": "EGF-like_comC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053333": {"description": "Cytochrome b6-f complex subunit 7", "go_ids": [], "go_terms": [], "name": "Cytochrome_b6-f_sub7", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053334": {"description": "Chloroplast Sensor Kinase", "go_ids": [], "go_terms": [], "name": "Chloroplast_Sensor_Kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053335": {"description": "Fatty Acid Desaturase CarF-like", "go_ids": [], "go_terms": [], "name": "Fatty_acid_desaturase_CarF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053336": {"description": "Rhoptry Surface-Associated Protein", "go_ids": [], "go_terms": [], "name": "Rhoptry_Surface_Assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053337": {"description": "Autotransporter-2 adhesin", "go_ids": [], "go_terms": [], "name": "AT-2_adhesin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053339": {"description": "FAS1 domain-containing protein", "go_ids": [], "go_terms": [], "name": "FAS1_domain_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053340": {"description": "Plant-specific TFIIB-related protein PTF2", "go_ids": [], "go_terms": [], "name": "PTF2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053341": {"description": "Oxidative Stress Response Globin-like", "go_ids": [], "go_terms": [], "name": "Oxidative_stress_globin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053342": {"description": "Exosome cofactor and PTGS suppressor", "go_ids": [], "go_terms": [], "name": "Exosome_cofactor/PTGS_suppr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053343": {"description": "Photosystem II mRNA-binding protein", "go_ids": [], "go_terms": [], "name": "PSII_mRNA-binding_protein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053344": {"description": "Cyclic AMP-inducible BP74-like", "go_ids": [], "go_terms": [], "name": "cAMP-inducible_BP74-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053345": {"description": "Ankyrin repeat-containing protein", "go_ids": [], "go_terms": [], "name": "Ankyrin_repeat-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053346": {"description": "Fra a 1-associated", "go_ids": [], "go_terms": [], "name": "Fra_a_1-associated", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053347": {"description": "Stabilizer of axonemal microtubules 3", "go_ids": [], "go_terms": [], "name": "SAXO3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053348": {"description": "Protein KPLCE", "go_ids": [], "go_terms": [], "name": "KPLCE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053350": {"description": "Chloroplast Vesiculation Inducer", "go_ids": [], "go_terms": [], "name": "CV_Inducer", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053351": {"description": "CRR41", "go_ids": [], "go_terms": [], "name": "CRR41", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053352": {"description": "FMRFamide-related peptide receptor", "go_ids": [], "go_terms": [], "name": "FMRFamide_rcpt", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053353": {"description": "Plant lipid transfer GPI-anchored", "go_ids": [], "go_terms": [], "name": "Plant_LTP_GPI-anchored", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053354": {"description": "Monoglucosyldiacylglycerol epimerase", "go_ids": [], "go_terms": [], "name": "MGDG_epimerase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053355": {"description": "RAD51-associated protein", "go_ids": [], "go_terms": [], "name": "RAD51-associated", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053356": {"description": "Calcium-regulated actin-bundling protein", "go_ids": [], "go_terms": [], "name": "Calcium-reg_actin-bundling", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053358": {"description": "Differentiation-associated protein 2-like", "go_ids": [], "go_terms": [], "name": "DIA2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053359": {"description": "Cysteine-rich Acidic Integral Membrane Protein", "go_ids": [], "go_terms": [], "name": "CRAM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053360": {"description": "Putative zinc finger domain-containing protein", "go_ids": [], "go_terms": [], "name": "Zinc_finger_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053361": {"description": "Vulval development negative regulator", "go_ids": [], "go_terms": [], "name": "Vulval_dev_neg_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053362": {"description": "Receptor polysaccharide phosphotransferase WefF-like", "go_ids": [], "go_terms": [], "name": "RPS_phosphotransferase_WefF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053363": {"description": "Leaf patterning domain-containing protein", "go_ids": [], "go_terms": [], "name": "Leaf_patterning_domain", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053364": {"description": "Fork-head Transcriptional Regulator", "go_ids": [], "go_terms": [], "name": "Fork-head_TF_regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053365": {"description": "Nematode receptor-like", "go_ids": [], "go_terms": [], "name": "Nematode_rcpt-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053366": {"description": "Leucine-rich repeat transmembrane protein", "go_ids": [], "go_terms": [], "name": "LRR_transmembrane", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053367": {"description": "G-protein alpha subunit activating GEF", "go_ids": [], "go_terms": [], "name": "G-alpha_activating_GEF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053368": {"description": "Viral Envelope Glycoprotein", "go_ids": [], "go_terms": [], "name": "Viral_Envelope_Glycoprotein", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053369": {"description": "SrfA-induced signaling protein", "go_ids": [], "go_terms": [], "name": "SrfA-induced_signal", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053370": {"description": "Quorum Sensing Complex Regulator", "go_ids": [], "go_terms": [], "name": "QS_Complex_Regulator", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053371": {"description": "Involucrin-like", "go_ids": [], "go_terms": [], "name": "Involucrin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053372": {"description": "Vulval toroid morphogenesis-associated protein", "go_ids": [], "go_terms": [], "name": "Vulval_toroid_morpho-assoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053373": {"description": "Glycine-rich receptor kinase regulator", "go_ids": [], "go_terms": [], "name": "GRP_receptor_kinase_reg", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053375": {"description": "UPF0265 domain-containing protein", "go_ids": [], "go_terms": [], "name": "UPF0265", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053376": {"description": "Serine acetyltransferase", "go_ids": [], "go_terms": [], "name": "Serine_acetyltransferase", "pathway_ids": ["PWY-7274", "PWY-7870", "PWY-6936", "PWY-8071", "R-MTU-936721"], "pathways": ["PWY-7274:t:D-cycloserine biosynthesis", "PWY-7870:t:L-cysteine biosynthesis VII (from S-sulfo-L-cysteine)", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-8071:t:N-3-oxalyl-L-2,3-diaminopropanoate biosynthesis", "R-MTU-936721:r:Cysteine synthesis from O-acetylserine"], "type": "Family"}, "IPR053377": {"description": "Iron uptake and transport EfeM/EfeO", "go_ids": [], "go_terms": [], "name": "Iron_uptake_EfeM/EfeO", "pathway_ids": ["R-HSA-9638482"], "pathways": ["R-HSA-9638482:r:Metal ion assimilation from the host"], "type": "Family"}, "IPR053378": {"description": "Prenyl diphosphate synthase", "go_ids": [], "go_terms": [], "name": "Prenyl_diphosphate_synthase", "pathway_ids": ["PWY-4681", "PWY-8382", "PWY-8389", "PWY-6691", "PWY-7529", "PWY-6383", "PWY-8243", "PWY-7998", "PWY-6262", "PWY-8442", "PWY-5802", "PWY-7493", "PWY-5815", "PWY-5817", "PWY-7102", "PWY-8084", "PWY-5123", "PWY-7182", "PWY-5120", "PWY-7517", "PWY-7720", "PWY-7141", "PWY-7492", "PWY-7540", "PWY-7520", "PWY-7555", "PWY-8388", "PWY-6659", "PWY-7410", "PWY-7407", "PWY-7599", "PWY-7405", "PWY-7719", "PWY-6681", "PWY-8461", "PWY-7906", "PWY-7543", "PWY-8253", "PWY-7372", "PWY-7736", "PWY-8083", "PWY-5122", "PWY-5979", "PWY-5893", "PWY-7603", "PWY-6859", "PWY-6403", "PWY-7532", "PWY-6936", "PWY-7605", "PWY-5816", "PWY-7708", "PWY-7721", "PWY-7659", "PWY-4502", "PWY-7572", "PWY-7709", "PWY-8080"], "pathways": ["PWY-4681:t:kievitone biosynthesis", "PWY-8382:t:diazepinomicin biosynthesis", "PWY-8389:t:penigequinolone biosynthesis", "PWY-6691:t:plaunotol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-7998:t:menaquinol-4 biosynthesis II", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-8442:t:hyperxanthone E biosynthesis", "PWY-5802:t:alizarin biosynthesis", "PWY-7493:t:paxilline and diprenylpaxilline biosynthesis", "PWY-5815:t:rubber biosynthesis", "PWY-5817:t:dodecaprenyl diphosphate biosynthesis", "PWY-7102:t:bisabolene biosynthesis (engineered)", "PWY-8084:t:daurichromenate biosynthesis", "PWY-5123:t:trans, trans-farnesyl diphosphate biosynthesis", "PWY-7182:t:linalool biosynthesis I", "PWY-5120:t:geranylgeranyl diphosphate biosynthesis", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7720:t:ophiobolin F biosynthesis", "PWY-7141:t:(3S)-linalool biosynthesis", "PWY-7492:t:paspaline biosynthesis", "PWY-7540:t:aflatrem biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-8388:t:aspoquinolone biosynthesis", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7410:t:ipsdienol biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-6681:t:neurosporaxanthin biosynthesis", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7906:t:rhizobitoxine biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-7736:t:stellatic acid biosynthesis", "PWY-8083:t:domoic acid biosynthesis", "PWY-5122:t:geranyl diphosphate biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-5893:t:tridecaprenyl diphosphate biosynthesis", "PWY-7603:t:stephacidin A biosynthesis", "PWY-6859:t:all-trans-farnesol biosynthesis", "PWY-6403:t:carrageenan biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6936:t:seleno-amino acid biosynthesis (plants)", "PWY-7605:t:roquefortine C biosynthesis", "PWY-5816:t:all trans undecaprenyl diphosphate biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-7721:t:methyl phomopsenoate biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-4502:t:wighteone and luteone biosynthesis", "PWY-7572:t:lolitrem B biosynthesis", "PWY-7709:t:(3R)-linalool biosynthesis", "PWY-8080:t:kainate biosynthesis"], "type": "Family"}, "IPR053380": {"description": "SbcCD Nuclease Subunit C", "go_ids": [], "go_terms": [], "name": "SbcCD_Nuclease_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053381": {"description": "SbcCD nuclease", "go_ids": [], "go_terms": [], "name": "SbcCD_nuclease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053382": {"description": "Bacterial ring-hydroxylating dioxygenase ferredoxin reductase", "go_ids": [], "go_terms": [], "name": "Ring-hydroxylating_dioxygenase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053383": {"description": "Phenol-soluble modulin alpha peptides", "go_ids": [], "go_terms": [], "name": "PSM_alpha_peptides", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053384": {"description": "SAM-dependent methyltransferase", "go_ids": [], "go_terms": [], "name": "SAM-dep_methyltransferase", "pathway_ids": ["R-MMU-196807", "R-RNO-209905", "R-SSC-209905", "R-MMU-209905", "R-HSA-156581", "R-HSA-196807", "R-HSA-209905", "R-HSA-2408552", "R-HSA-2408508", "R-MMU-156581"], "pathways": ["R-MMU-196807:r:Nicotinate metabolism", "R-RNO-209905:r:Catecholamine biosynthesis", "R-SSC-209905:r:Catecholamine biosynthesis", "R-MMU-209905:r:Catecholamine biosynthesis", "R-HSA-156581:r:Methylation", "R-HSA-196807:r:Nicotinate metabolism", "R-HSA-209905:r:Catecholamine biosynthesis", "R-HSA-2408552:r:Methylation of MeSeH for excretion", "R-HSA-2408508:r:Metabolism of ingested SeMet, Sec, MeSec into H2Se", "R-MMU-156581:r:Methylation"], "type": "Family"}, "IPR053385": {"description": "ABC_transport_system_permease", "go_ids": [], "go_terms": [], "name": "ABC_transport_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053386": {"description": "Methyl-branched fatty acid synthase", "go_ids": [], "go_terms": [], "name": "MBFA_synthase", "pathway_ids": ["R-MTU-9635470"], "pathways": ["R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis"], "type": "Family"}, "IPR053387": {"description": "Bacterial ring-hydroxylating dioxygenase ferredoxin", "go_ids": [], "go_terms": [], "name": "Ring-hydroxylating_fd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053388": {"description": "Glu/Leu/Phe/Val dehydrogenases", "go_ids": [], "go_terms": [], "name": "GLPV_dehydrogenases", "pathway_ids": ["PWY-5766"], "pathways": ["PWY-5766:t:L-glutamate degradation X"], "type": "Family"}, "IPR053389": {"description": "Pyruvate Synthase Subunit PorD", "go_ids": [], "go_terms": [], "name": "Pyruvate_synthase_PorD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053390": {"description": "Pyruvate Synthase Subunit PorA", "go_ids": [], "go_terms": [], "name": "Pyruvate_synthase_PorA", "pathway_ids": ["PWY-6863", "PWY-6588", "PWY-8275", "PWY-5493", "PWY-5600", "PWY-6142", "PWY-8377", "PWY-6587", "PWY-5497", "PWY-6876", "PWY-8189", "PWY-8303", "PWY-5538", "PWY-5392", "PWY-6583", "PWY-5483"], "pathways": ["PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-6588:t:pyruvate fermentation to acetone", "PWY-8275:t:pyruvate decarboxylation to acetyl CoA III", "PWY-5493:t:reductive monocarboxylic acid cycle", "PWY-5600:t:pyruvate fermentation to acetate VII", "PWY-6142:t:gluconeogenesis II (Methanobacterium 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"PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis"], "type": "Family"}, "IPR053392": {"description": "Transposase IS30-like", "go_ids": [], "go_terms": [], "name": "Transposase_IS30-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053393": {"description": "Meromycolate extension acyl carrier", "go_ids": [], "go_terms": [], "name": "Meromycolate-ACP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053394": {"description": "Signal Recognition Particle 19 kDa", "go_ids": [], "go_terms": [], "name": "SRP19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053395": {"description": "CRISPR-associated endoribonuclease Cas13a", "go_ids": [], "go_terms": [], "name": "Cas13a_endoribonuclease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053396": {"description": "Endonuclease V-like", "go_ids": [], "go_terms": [], "name": "Endonuclease_V-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053397": {"description": "Archaeal Riboflavin Kinase", "go_ids": [], "go_terms": [], "name": "Archaeal_Riboflavin_Kinase", "pathway_ids": ["PWY-6167"], "pathways": ["PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Family"}, "IPR053398": {"description": "Hydroxypyruvate and 2-oxo-tetronate isomerases", "go_ids": [], "go_terms": [], "name": "HPT_OtnI_isomerases", "pathway_ids": ["PWY-7873", "PWY-7874"], "pathways": ["PWY-7873:t:D-erythronate degradation II", "PWY-7874:t:L-threonate degradation"], "type": "Family"}, "IPR053399": {"description": "2-oxoacid:ferredoxin oxidoreductase beta subunit", "go_ids": [], "go_terms": [], "name": "2-oxoacid:Fd_oxidored_beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053400": {"description": "2-oxoacid:ferredoxin oxidoreductase alpha", "go_ids": [], "go_terms": [], "name": "2-oxoacid_Fdx_oxidoreductase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053401": {"description": "Transcriptional regulator GfcR, halobacteria", "go_ids": [], "go_terms": [], "name": "GcfR_halob", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053402": {"description": "Quorum sensing regulatory protein LuxO", "go_ids": [], "go_terms": [], "name": "QS_regulatory_LuxO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053403": {"description": "Quorum sensing phosphorelay intermediate", "go_ids": [], "go_terms": [], "name": "QS_phosphorelay_intermediate", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053404": {"description": "Lactaldehyde dehydrogenase", "go_ids": [], "go_terms": [], "name": "Lactaldehyde_DH", "pathway_ids": ["PWY-5197", "PWY-6713", "PWY-5458"], "pathways": ["PWY-5197:t:lactate biosynthesis (archaea)", "PWY-6713:t:L-rhamnose degradation II", "PWY-5458:t:methylglyoxal degradation V"], "type": "Family"}, "IPR053405": {"description": "Molybdate/Tungstate ABC Transporter Permease", "go_ids": [], "go_terms": [], "name": "Mo/W_ABC_Transporter_Permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053406": {"description": "L-fuculose phosphate aldolase", "go_ids": [], "go_terms": [], "name": "Fuculose-P_aldolase", "pathway_ids": ["PWY-5197", "PWY-8440"], "pathways": ["PWY-5197:t:lactate biosynthesis (archaea)", "PWY-8440:t:nucleoside and nucleotide degradation (halobacteria)"], "type": "Family"}, "IPR053407": {"description": "Diaminopimelate Epimerase", "go_ids": [], "go_terms": [], "name": "DAP_Epimerase", "pathway_ids": ["PWY-5097", "PWY-2941"], "pathways": ["PWY-5097:t:L-lysine biosynthesis VI", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Family"}, "IPR053408": {"description": "MlaE Permease", "go_ids": [], "go_terms": [], "name": "MlaE_Permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053409": {"description": "Mannuronan C5-epimerase", "go_ids": [], "go_terms": [], "name": "Mannuronan_C5-epimerase", "pathway_ids": ["PWY-6073", "PWY-6082"], "pathways": ["PWY-6073:t:alginate biosynthesis I (algal)", "PWY-6082:t:alginate biosynthesis II (bacterial)"], "type": "Family"}, "IPR053410": {"description": "Mycobacterial enoyl-ACP reductase", "go_ids": [], "go_terms": [], "name": "Mycobact_enoyl-ACP_red", "pathway_ids": ["PWY-7664", "PWY-8175", "PWY-7858", "PWY-8174", "PWY-8203", "PWY-7663", "PWYG-321", "PWY-5971", "PWY-5973", "PWY-5989", "PWY-6519", "PWY-6282", "PWY-8173"], "pathways": ["PWY-7664:t:oleate biosynthesis IV (anaerobic)", "PWY-8175:t:even iso-branched-chain fatty acid biosynthesis", "PWY-7858:t:(5Z)-dodecenoate biosynthesis II", "PWY-8174:t:odd iso-branched-chain fatty acid biosynthesis", "PWY-8203:t:8-amino-7-oxononanoate biosynthesis IV", "PWY-7663:t:gondoate biosynthesis (anaerobic)", "PWYG-321:t:mycolate biosynthesis", "PWY-5971:t:palmitate biosynthesis II (type II fatty acid synthase)", "PWY-5973:t:cis-vaccenate biosynthesis", "PWY-5989:t:stearate biosynthesis II (bacteria and plants)", "PWY-6519:t:8-amino-7-oxononanoate biosynthesis I", "PWY-6282:t:palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)", "PWY-8173:t:anteiso-branched-chain fatty acid biosynthesis"], "type": "Family"}, "IPR053411": {"description": "Malate Dehydrogenase", "go_ids": [], "go_terms": [], "name": "MDH", "pathway_ids": ["PWY-7383", "PWY-8086", "PWY-1622", "PWY-6728", "PWY-7115", "PWY-561", "PWY-5690", "PWY-5392", "PWY-6969"], "pathways": ["PWY-7383:t:anaerobic energy metabolism (invertebrates, cytosol)", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-1622:t:formaldehyde assimilation I (serine pathway)", "PWY-6728:t:methylaspartate cycle", "PWY-7115:t:C4 photosynthetic carbon assimilation cycle, NAD-ME type", "PWY-561:t:superpathway of glyoxylate cycle and fatty acid degradation", "PWY-5690:t:TCA cycle II (plants and fungi)", "PWY-5392:t:reductive TCA cycle II", "PWY-6969:t:TCA cycle V (2-oxoglutarate synthase)"], "type": "Family"}, "IPR053412": {"description": "Pyruvate Synthase Subunit PorC", "go_ids": [], "go_terms": [], "name": "Pyruvate_synthase_PorC", "pathway_ids": ["PWY-6863", "PWY-6588", "PWY-8275", "PWY-5493", "PWY-5600", "PWY-6142", "PWY-8377", "PWY-6587", "PWY-5497", "PWY-6876", "PWY-8189", "PWY-8303", "PWY-5538", "PWY-5392", "PWY-6583", "PWY-5483"], "pathways": ["PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-6588:t:pyruvate fermentation to acetone", "PWY-8275:t:pyruvate decarboxylation to acetyl CoA III", "PWY-5493:t:reductive monocarboxylic acid cycle", "PWY-5600:t:pyruvate fermentation to acetate VII", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-6587:t:pyruvate fermentation to ethanol III", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-6876:t:isopropanol biosynthesis (engineered)", "PWY-8189:t:L-alanine degradation V (oxidative Stickland reaction)", "PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-5538:t:pyruvate fermentation to acetate VI", "PWY-5392:t:reductive TCA cycle II", "PWY-6583:t:pyruvate fermentation to butanol I", "PWY-5483:t:pyruvate fermentation to acetate III"], "type": "Family"}, "IPR053413": {"description": "Autoinducer 2 sensor kinase/phosphatase", "go_ids": [], "go_terms": [], "name": "AI-2_sensor_kinase/phosphatase", "pathway_ids": ["PWY-6686", "PWY-6366", "PWY-6575", "PWY-8176", "PWY-8430", "PWY-6627", "PWY-7863", "PWY-7881", "PWY-7321", "PWY-7882", "PWY-8052", "PWY-8372", "PWY-6365", "PWY-6352", "PWY-6991", "PWY-7878", "PWY-7531", "PWY-8373", "PWY-4702", "PWY-7119", "PWY-7018", "PWY-6990", "PWY-6148", "PWY-8247", "PWY-8367", "PWY-6724", "PWY-6368", "PWY-6955", "PWY-6720", "PWY-8282", "PWY-8429", "PWY-5491", "PWY-6456", "PWY-7771", "PWY-6664"], "pathways": ["PWY-6686:t:mannosylglucosylglycerate biosynthesis I", "PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6575:t:juvenile hormone III biosynthesis I", "PWY-8176:t:geraniol biosynthesis (cytosol)", "PWY-8430:t:1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-7863:t:roseoflavin biosynthesis", "PWY-7881:t:virginiae butanolide type gamma-butyrolactones biosynthesis", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7882:t:IM-2 type gamma-butyrolactones biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "PWY-8372:t:erythritol biosynthesis I", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6352:t:3-phosphoinositide biosynthesis", "PWY-6991:t:(-)-camphor biosynthesis", "PWY-7878:t:A-factor gamma-butyrolactone biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-8373:t:erythritol biosynthesis II", "PWY-4702:t:phytate degradation I", "PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-7018:t:paromomycin biosynthesis", "PWY-6990:t:(+)-camphor biosynthesis", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8247:t:(Kdo)2-lipid A biosynthesis (P. gingivalis)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6724:t:starch degradation II", "PWY-6368:t:3-phosphoinositide degradation", "PWY-6955:t:lincomycin A biosynthesis", "PWY-6720:t:toyocamycin biosynthesis", "PWY-8282:t:adenosylcobinamide-GDP salvage from assorted adenosylcobamides", "PWY-8429:t:1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis", "PWY-5491:t:diethylphosphate degradation", "PWY-6456:t:serinol biosynthesis", "PWY-7771:t:butachlor degradation", "PWY-6664:t:di-myo-inositol phosphate biosynthesis"], "type": "Family"}, "IPR053414": {"description": "Fructose-bisphosphate aldolase class 1", "go_ids": [], "go_terms": [], "name": "FBA_class_1", "pathway_ids": ["PWY-1042", "PWY-8178", "PWY-8404", "PWY-6142", "PWY-1861", "PWY-7385", "PWY-5484"], "pathways": ["PWY-1042:t:glycolysis IV", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-8404:t:glycolysis VI (from fructose)", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-5484:t:glycolysis II (from fructose 6-phosphate)"], "type": "Family"}, "IPR053415": {"description": "Entner-Doudoroff pathway aldolase", "go_ids": [], "go_terms": [], "name": "ED_pathway_aldolase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053416": {"description": "ATP-dependent DNA Hel308 helicase", "go_ids": [], "go_terms": [], "name": "Hel308_helicase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053417": {"description": "Phenolic Acid Decarboxylase UbiD-like", "go_ids": [], "go_terms": [], "name": "PAD_UbiD-like", "pathway_ids": ["PWY-5870", "PWY-6309", "PWY-5871", "PWY-7007", "PWY-6322", "PWY-6055", "PWY-8037", "PWY-7769", "PWY-7557", "PWY-6262", "PWY-6627", "PWY-8376", "PWY-5163", "PWY-6340", "PWY-5956", "PWY-5873", "PWY-7154", "PWY-7620", "PWY-3542", "PWY-6633", "PWY-7230", "PWY-6959", "PWY-7931", "PWY-7352", "PWY-5113", "PWY-7372", "PWY-5872", "PWY-7782", "PWY-7690", "PWY-8158", "PWY-5826", "PWY-7419", "PWY-6935", "PWY-8166", "PWY-7742", "PWY-3385", "PWY-7480", "PWY-7741", "PWY-8387", "PWY-8085", "PWY-5706", "PWY-8358"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6055:t:dimethylsulfoniopropanoate biosynthesis II (Spartina)", "PWY-8037:t:saliniketal A biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8376:t:benzene degradation III (anaerobic)", "PWY-5163:t:p-cumate degradation to 2-hydroxypentadienoate", "PWY-6340:t:5,5'-dehydrodivanillate degradation", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-7154:t:ergosterol biosynthesis II", "PWY-7620:t:naphthalene degradation (anaerobic)", "PWY-3542:t:choline biosynthesis II", "PWY-6633:t:caffeine degradation V (bacteria, via trimethylurate)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-6959:t:L-ascorbate degradation V", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-5113:t:UDP-D-apiose biosynthesis (from UDP-D-glucuronate)", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7690:t:holomycin biosynthesis", "PWY-8158:t:ibotenate and muscimol biosynthesis", "PWY-5826:t:hypoglycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6935:t:seleno-amino acid detoxification and volatilization II", "PWY-8166:t:emodin biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-3385:t:choline biosynthesis I", "PWY-7480:t:2,3-dihydroxybenzoate degradation", "PWY-7741:t:phthiocerol biosynthesis", "PWY-8387:t:microcin C biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-5706:t:alliin metabolism", "PWY-8358:t:curacin A biosynthesis"], "type": "Family"}, "IPR053418": {"description": "Archaeosine Synthase Type 1", "go_ids": [], "go_terms": [], "name": "Archaeosine_synthase_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053419": {"description": "Mycobacterial FAS-II 3-oxoacyl-ACP reductase", "go_ids": [], "go_terms": [], "name": "FAS-II_3-oxoacyl-ACP_reductase", "pathway_ids": ["PWY-7664", "PWY-8175", "PWY-7858", "PWY-8174", "PWY-8203", "PWY-7663", "PWY-5367", "PWYG-321", "PWY-5971", "PWY-7388", "PWY-5973", "PWY-8427", "PWY-5989", "PWY-8279", "PWY-8280", "PWY-6519", 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of PD-L1(CD274) transcription", "R-MMU-2032785:r:YAP1- and WWTR1 (TAZ)-stimulated gene expression", "R-DME-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CFA-2028269:r:Signaling by Hippo", "R-DRE-1251985:r:Nuclear signaling by ERBB4", "R-DME-8951671:r:RUNX3 regulates YAP1-mediated transcription", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation"], "type": "Conserved_site"}, "IPR053820": {"description": "MSL3 chromodomain-like", "go_ids": [], "go_terms": [], "name": "MSL3_chromo-like", "pathway_ids": ["R-MMU-3214847", "R-HSA-3214847", "R-DME-3214847"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-HSA-3214847:r:HATs acetylate histones", "R-DME-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR053821": {"description": "Splicing regulator SDE2, ubiquitin domain", "go_ids": [], "go_terms": [], "name": "Sde2_Ubi", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR053822": {"description": "SDE2-like domain", "go_ids": [], "go_terms": [], "name": "SDE2-like_dom", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR053823": {"description": "CLIC, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CLIC_N", "pathway_ids": ["R-HSA-2672351", "R-HSA-5578775", "R-RNO-2672351", "R-HSA-9662361", "R-HSA-9662360", "R-RNO-5578775"], "pathways": ["R-HSA-2672351:r:Stimuli-sensing channels", "R-HSA-5578775:r:Ion homeostasis", "R-RNO-2672351:r:Stimuli-sensing channels", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-RNO-5578775:r:Ion homeostasis"], "type": "Domain"}, "IPR053824": {"description": "Protein of unknown function DUF7010", "go_ids": [], "go_terms": [], "name": "DUF7010", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053825": {"description": "Protein of unknown function DUF7009", "go_ids": [], "go_terms": [], "name": "DUF7009", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053826": {"description": "WD repeat-containing protein 75", "go_ids": ["GO:0032040", "GO:0042254", "GO:0003723", "GO:0045943"], "go_terms": ["GO:0032040:small-subunit processome:C", "GO:0042254:ribosome biogenesis:P", "GO:0003723:RNA binding:F", "GO:0045943:positive regulation of transcription by RNA polymerase I:P"], "name": "WDR75", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Family"}, "IPR053827": {"description": "Baseplate structural protein Gp10, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gp10_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053828": {"description": "SMN1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SMN1-like_C", "pathway_ids": ["PWY-7821", "PWY-7185", "PWY-5381", "PWY-6596", "PWY-5695", "PWY-6607", "PWY-6608", "PWY-6606"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-5381:t:NAD salvage (plants)", "PWY-6596:t:adenosine nucleotides degradation I", "PWY-5695:t:inosine 5'-phosphate degradation", "PWY-6607:t:guanosine nucleotides degradation I", "PWY-6608:t:guanosine nucleotides degradation III", "PWY-6606:t:guanosine nucleotides degradation II"], "type": "Domain"}, "IPR053829": {"description": "XLF-like, coiled-coil region", "go_ids": [], "go_terms": [], "name": "XLF-like_CC", "pathway_ids": ["R-RNO-5693571", "R-MMU-5693571", "R-DRE-5693571", "R-HSA-5693571"], "pathways": ["R-RNO-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-DRE-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)"], "type": "Domain"}, "IPR053830": {"description": "Domain of unknown function DUF6922", "go_ids": [], "go_terms": [], "name": "DUF6922", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053831": {"description": "SOGP, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SOGP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053832": {"description": "Domain of unknown function DUF6924", "go_ids": [], "go_terms": [], "name": "DUF6924", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053833": {"description": "Small archaeal modifier protein 2", "go_ids": [], "go_terms": [], "name": "SAMP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053834": {"description": "Ubiquitin-like small modifier protein 2, halobacteria", "go_ids": [], "go_terms": [], "name": "SAMP2_halobacteria", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053835": {"description": "Set1/Ash2 histone methyltransferase complex subunit ASH2-like, winged-helix", "go_ids": [], "go_terms": [], "name": "ASH2L-like_WH", "pathway_ids": ["R-MMU-8936459", "R-HSA-5617472", "R-MMU-3214841", "R-DME-9772755", "R-HSA-3769402", "R-HSA-9772755", "R-CEL-8936459", "R-MMU-9818564", "R-HSA-8936459", "R-HSA-9944997", "R-MMU-201722", "R-CEL-3214841", "R-DME-201722", "R-HSA-9841922", "R-HSA-201722", "R-HSA-9909649", "R-SPO-9772755", "R-DME-8936459", "R-HSA-3214841", "R-HSA-9818564", "R-CEL-9772755", "R-MMU-9772755", "R-DME-9909649"], "pathways": ["R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DME-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-9944997:r:Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-CEL-3214841:r:PKMTs methylate histone lysines", "R-DME-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-SPO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9818564:r:Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-CEL-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription"], "type": "Domain"}, "IPR053836": {"description": "Nuclear-export cofactor Arc1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Arc1-like_N", "pathway_ids": ["R-SCE-156842", "R-MMU-9856649", "R-HSA-9856649", "R-HSA-2408522", "R-DME-156842", "R-HSA-6782315", "R-HSA-379716"], "pathways": ["R-SCE-156842:r:Eukaryotic Translation Elongation", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-DME-156842:r:Eukaryotic Translation Elongation", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR053838": {"description": "Protein of unknown function DUF6925", "go_ids": [], "go_terms": [], "name": "DUF6925", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053839": {"description": "Domain of unknown function DUF6926", "go_ids": [], "go_terms": [], "name": "DUF6926", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053840": {"description": "Hfq-related", "go_ids": [], "go_terms": [], "name": "Hfq_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053841": {"description": "Condensin complex protein MksE", "go_ids": [], "go_terms": [], "name": "MksE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053842": {"description": "Mobilization protein NikA-like", "go_ids": [], "go_terms": [], "name": "NikA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053843": {"description": "DnaD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DnaD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053844": {"description": "Allophanate hydrolase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053845": {"description": "Domain of unknown function DUF6927", "go_ids": [], "go_terms": [], "name": "DUF6927", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053846": {"description": "Histidyl-tRNA synthetase HisZ, C-terminal domain, Bacillales", "go_ids": ["GO:0006427", "GO:0004821"], "go_terms": ["GO:0006427:histidyl-tRNA aminoacylation:P", "GO:0004821:histidine-tRNA ligase activity:F"], "name": "HisZ_C_Bacillales", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053847": {"description": "Protein of unknown function DUF6928", "go_ids": [], "go_terms": [], "name": "DUF6928", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053848": {"description": "DNA polymerase IV/DNA polymerase iota-like, thumb domain", "go_ids": ["GO:0003887"], "go_terms": ["GO:0003887:DNA-directed DNA polymerase 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synthesis by POLK", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-GGA-353503:r:Translesion synthesis by Pol kappa", "R-GGA-110312:r:Translesion synthesis by REV1", "R-GGA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-5656121:r:Translesion synthesis by POLI"], "type": "Domain"}, "IPR053849": {"description": "DUF5817, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF5817_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053850": {"description": "Glycoside hydrolase 123, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Glyco_hydro_123_N_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053851": {"description": "Protein of unknown function DUF6929", "go_ids": [], "go_terms": [], "name": "DUF6929", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053852": {"description": "Protein of unknown function DUF6910", "go_ids": [], "go_terms": [], "name": "DUF6910", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053853": {"description": "Antitoxin FitA-like, ribbon-helix-helix", "go_ids": [], "go_terms": [], "name": "FitA-like_RHH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053854": {"description": "Domain of unknown function DUF7018", "go_ids": [], "go_terms": [], "name": "DUF7018", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053855": {"description": "Protein of unknown function DUF6931", "go_ids": [], "go_terms": [], "name": "DUF6931", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053856": {"description": "Cytokine receptor-like factor 2-like, domain 1", "go_ids": [], "go_terms": [], "name": "TSLPR_D1", "pathway_ids": ["R-MMU-8985947", "R-MMU-6785807", "R-BTA-8985947", "R-HSA-9020958", "R-MMU-1266695", "R-BTA-5673001", "R-BTA-9020958", "R-HSA-9701898", "R-HSA-8985947", "R-MMU-8983432", "R-HSA-6785807", "R-HSA-8983432", "R-BTA-8983432", "R-HSA-5673001", "R-MMU-9020958", "R-MMU-912526", "R-BTA-1266695", "R-BTA-912526", "R-HSA-912526", "R-BTA-9020558", "R-MMU-9020558", "R-BTA-6785807", "R-MMU-5673001", "R-HSA-1266695", "R-HSA-9020558"], "pathways": ["R-MMU-8985947:r:Interleukin-9 signaling", "R-MMU-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-BTA-8985947:r:Interleukin-9 signaling", "R-HSA-9020958:r:Interleukin-21 signaling", "R-MMU-1266695:r:Interleukin-7 signaling", "R-BTA-5673001:r:RAF/MAP kinase cascade", "R-BTA-9020958:r:Interleukin-21 signaling", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-8985947:r:Interleukin-9 signaling", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-8983432:r:Interleukin-15 signaling", "R-BTA-8983432:r:Interleukin-15 signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-MMU-9020958:r:Interleukin-21 signaling", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-BTA-1266695:r:Interleukin-7 signaling", "R-BTA-912526:r:Interleukin receptor SHC signaling", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-9020558:r:Interleukin-2 signaling", "R-MMU-9020558:r:Interleukin-2 signaling", "R-BTA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-9020558:r:Interleukin-2 signaling"], "type": "Domain"}, "IPR053857": {"description": "CRISPR system endoribonuclease Csx1-like, CARF domain", "go_ids": [], "go_terms": [], "name": "Csx1_CARF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053858": {"description": "Arb2 domain", "go_ids": [], "go_terms": [], "name": "Arb2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053859": {"description": "Diphosphomevalonate decarboxylase-like N-terminal domain", "go_ids": [], "go_terms": [], "name": "MVD-like_N", "pathway_ids": ["PWY-7391", "PWY-922", "R-SCE-9969896", "R-DRE-9969896", "R-MMU-9969896", "R-SPO-446199", "R-BTA-446199", "R-SCE-446199", "R-DDI-446199", "R-RNO-9969896", "R-DRE-446199", "R-BTA-9969896", "R-DDI-9969896", "R-RNO-446199", "R-MMU-446199", "R-HSA-446199", "R-HSA-2426168", "R-HSA-9969896", "R-SPO-9969896"], "pathways": ["PWY-7391:t:isoprene biosynthesis II (engineered)", "PWY-922:t:mevalonate pathway I (eukaryotes and bacteria)", "R-SCE-9969896:r:Lanosterol biosynthesis", "R-DRE-9969896:r:Lanosterol biosynthesis", "R-MMU-9969896:r:Lanosterol biosynthesis", "R-SPO-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-446199:r:Synthesis of dolichyl-phosphate", "R-SCE-446199:r:Synthesis of dolichyl-phosphate", "R-DDI-446199:r:Synthesis of dolichyl-phosphate", "R-RNO-9969896:r:Lanosterol biosynthesis", "R-DRE-446199:r:Synthesis of dolichyl-phosphate", "R-BTA-9969896:r:Lanosterol biosynthesis", "R-DDI-9969896:r:Lanosterol biosynthesis", "R-RNO-446199:r:Synthesis of dolichyl-phosphate", "R-MMU-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-446199:r:Synthesis of dolichyl-phosphate", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-9969896:r:Lanosterol biosynthesis", "R-SPO-9969896:r:Lanosterol biosynthesis"], "type": "Domain"}, "IPR053860": {"description": "Protein of unknown function DUF6932", "go_ids": [], "go_terms": [], "name": "DUF6932", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053861": {"description": "Bacteriophage Mu Gp45, N-terminal", "go_ids": [], "go_terms": [], "name": "Phage_Mu_Gp45_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053863": {"description": "Glyoxalase/Bleomycin resistance-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Glyoxy/Ble-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053864": {"description": "Domain of unknown function DUF6933", "go_ids": [], "go_terms": [], "name": "DUF6933", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053865": {"description": "Protein of unknown function DUF6934", "go_ids": [], "go_terms": [], "name": "DUF6934", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053866": {"description": "PhyR, sigma2 domain", "go_ids": [], "go_terms": [], "name": "PhyR_sigma2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053867": {"description": "PhyR, sigma4 domain", "go_ids": [], "go_terms": [], "name": "PhyR_sigma4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053868": {"description": "Pel9A-like, right handed beta-helix region", "go_ids": [], "go_terms": [], "name": "Pel9A-like_beta_helix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053869": {"description": "C5a peptidase, third Fn3 domain", "go_ids": [], "go_terms": [], "name": "ScpA_Fn3_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053870": {"description": "TiaS-like, TCKD domain", "go_ids": [], "go_terms": [], "name": "TiaS-like_TCKD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053871": {"description": "CATSPERG, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "CATSPERG_beta-prop", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR053872": {"description": "CATSPERG, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CATSPERG_N", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR053873": {"description": "CATSPERG, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CATSPERG_C", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR053874": {"description": "CATSPERG, Ig-like domain", "go_ids": [], "go_terms": [], "name": "CATSPERG_Ig-like", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR053875": {"description": "Cytochrome c-type protein NrfB-like domain", "go_ids": [], "go_terms": [], "name": "Cytochrom_c_NrfB-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053876": {"description": "Phage integrase, central domain", "go_ids": [], "go_terms": [], "name": "Phage_int_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053877": {"description": "Anti-sigma-K factor RskA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RskA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053878": {"description": "Major fimbrium subunit FimA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FimA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053879": {"description": "HYDIN/VesB/CFA65-like, Ig-like domain", "go_ids": [], "go_terms": [], "name": "HYDIN_VesB_CFA65-like_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053880": {"description": "GPR180-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GPR180-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053881": {"description": "Utp8, C-terminal", "go_ids": [], "go_terms": [], "name": "Utp8_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053882": {"description": "Nlrc4-like, winged helix domain", "go_ids": [], "go_terms": [], "name": "Nlrc4-like_WHD", "pathway_ids": ["R-HSA-6803207", "R-HSA-844623"], "pathways": ["R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR053883": {"description": "DUF3097, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF3097_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053886": {"description": "DUF4026, middle domain", "go_ids": [], "go_terms": [], "name": "DUF4026_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053887": {"description": "Major capsid protein V20, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MCP_V20_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053888": {"description": "MRM3-like, substrate binding domain", "go_ids": [], "go_terms": [], "name": "MRM3-like_sub_bind", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-6793080"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-6793080:r:rRNA modification in the mitochondrion"], "type": "Domain"}, "IPR053889": {"description": "Major capsid protein V20, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Sputnik_MCP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053890": {"description": "Hen1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Hen1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053891": {"description": "Shisa, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Shisa_N", "pathway_ids": ["R-BTA-8957275", "R-MMU-381426", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-BTA-381426"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR053892": {"description": "MoaF-like", "go_ids": [], "go_terms": [], "name": "MoaF-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053893": {"description": "Polycomb protein EED-like, insertion domain", "go_ids": [], "go_terms": [], "name": "PRC2_EED-like_ins", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053894": {"description": "Out at first protein, BRICHOS-like domain", "go_ids": [], "go_terms": [], "name": "OAF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053895": {"description": "Domain of unknown function DUF7011", "go_ids": [], "go_terms": [], "name": "DUF7011", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053896": {"description": "Butyrophilin subfamily 3 member A2-like, Ig-C domain", "go_ids": [], "go_terms": [], "name": "BTN3A2-like_Ig-C", "pathway_ids": ["R-CEL-373753", "R-MMU-8851680", "R-MMU-9931295", "R-RNO-8851680", "R-MMU-389948", "R-HSA-8851680", "R-HSA-389948", "R-HSA-9931295", "R-HSA-9927354"], "pathways": ["R-CEL-373753:r:Nephrin family interactions", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-RNO-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-389948:r:Co-inhibition by PD-1", "R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-HSA-389948:r:Co-inhibition by PD-1", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9927354:r:Co-stimulation by ICOS"], "type": "Domain"}, "IPR053897": {"description": "Out at first, C-terminal", "go_ids": [], "go_terms": [], "name": "Oaf_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053898": {"description": "Shieldin complex subunit 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SHLD1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053899": {"description": "C5orf34-like, second domain", "go_ids": [], "go_terms": [], "name": "C5orf34-like_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053900": {"description": "C5orf34-like domain", "go_ids": [], "go_terms": [], "name": "C5orf34-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053901": {"description": "C5orf34-like", "go_ids": [], "go_terms": [], "name": "C5orf34-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053902": {"description": "Interleukin 33, C-terminal", "go_ids": [], "go_terms": [], "name": "IL33_C", "pathway_ids": ["R-MMU-5689880", "R-HSA-9014843", "R-HSA-6811558", "R-RNO-6811558", "R-CFA-6811558", "R-HSA-5689880", "R-MMU-6811558", "R-RNO-1257604", "R-RNO-9014843", "R-MMU-9014843", "R-HSA-1257604", "R-MMU-1257604", "R-RNO-5689880", "R-CFA-1257604", "R-CFA-5689880"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-9014843:r:Interleukin-33 signaling", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CFA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-9014843:r:Interleukin-33 signaling", "R-MMU-9014843:r:Interleukin-33 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-CFA-1257604:r:PIP3 activates AKT signaling", "R-CFA-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR053903": {"description": "CATSPERB, head domain", "go_ids": [], "go_terms": [], "name": "CATSPERB_head", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR053904": {"description": "CATSPERB, Ig-like domain", "go_ids": [], "go_terms": [], "name": "CATSPERB_Ig-like", "pathway_ids": ["R-MMU-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR053905": {"description": "Elongation factor G-like, domain II", "go_ids": [], "go_terms": [], "name": "EF-G-like_DII", "pathway_ids": ["R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-5419276", "R-RNO-5419276", "R-HSA-5368286"], "pathways": ["R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-5419276:r:Mitochondrial translation termination", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation"], "type": "Domain"}, "IPR053907": {"description": "Domain of unknown function DUF6935", "go_ids": [], "go_terms": [], "name": "DUF6935", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053908": {"description": "Chloramphenicol halogenase CmlS, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CmlS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053909": {"description": "Enoyl-acyl carrier protein reductase FabMG", "go_ids": [], "go_terms": [], "name": "FabMG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053910": {"description": "RsmI, HTH domain", "go_ids": [], "go_terms": [], "name": "RsmI_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053911": {"description": "PGAP2IP, second transmembrane domain", "go_ids": [], "go_terms": [], "name": "PGAP2IP_TM_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053912": {"description": "PGAP2IP, first transmembrane domain", "go_ids": [], "go_terms": [], "name": "PGAP2IP_TM_1nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053913": {"description": "DarT1-associated NADAR antitoxin", "go_ids": [], "go_terms": [], "name": "NADAR-DarT1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053914": {"description": "Dispersed gene family protein 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DGF-1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053915": {"description": "Dispersed gene family protein 1, beta-sheet domain", "go_ids": [], "go_terms": [], "name": "DGF-1_b-sheet_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053916": {"description": "Protein of unknown function DUF6978", "go_ids": [], "go_terms": [], "name": "DUF6978", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053917": {"description": "Protein of unknown function DUF6979", "go_ids": [], "go_terms": [], "name": "DUF6979", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR053918": {"description": "Domain of unknown function DUF6980", "go_ids": [], "go_terms": [], "name": "DUF6980", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053919": {"description": "Treslin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Treslin_N", "pathway_ids": ["R-HSA-69273", "R-MMU-69273", "R-DRE-69273"], "pathways": ["R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DRE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition"], "type": "Domain"}, "IPR053920": {"description": "Treslin, STD domain", "go_ids": [], "go_terms": [], "name": "Treslin_STD", "pathway_ids": ["R-HSA-69273", "R-MMU-69273", "R-DRE-69273"], "pathways": ["R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DRE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition"], "type": "Domain"}, "IPR053921": {"description": "MKRN2 opposite strand protein-like, C-terminal", "go_ids": [], "go_terms": [], "name": "MKRN2OS-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053922": {"description": "MKRN2 opposite strand protein-like, N-terminal", "go_ids": [], "go_terms": [], "name": "MKRN2OS-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053923": {"description": "Replication protein RepB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RepB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053924": {"description": "RecX, second three-helical domain", "go_ids": [], "go_terms": [], "name": "RecX_HTH_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053925": {"description": "RecX, third three-helical domain", "go_ids": [], "go_terms": [], "name": "RecX_HTH_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053926": {"description": "RecX, first three-helical domain", "go_ids": [], "go_terms": [], "name": "RecX_HTH_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053927": {"description": "Flagellar hook-associated protein FlgK, helical domain", "go_ids": [], "go_terms": [], "name": "FlgK_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053928": {"description": "Nonstructural protein NS-S, N-terminal, bunyaviral", "go_ids": [], "go_terms": [], "name": "NS-S_N_bunyaviral", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053929": {"description": "Nonstructural protein NS-S, WIV domain, bunyaviral", "go_ids": [], "go_terms": [], "name": "NS-S_WIV_bunyaviral", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053930": {"description": "RapZ-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RapZ-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053931": {"description": "RapZ, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RapZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053932": {"description": "Glabrous enhancer-binding protein-like, DBD domain", "go_ids": [], "go_terms": [], "name": "GeBP-like_DBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053933": {"description": "Glabrous enhancer-binding protein-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GeBP-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053934": {"description": "HTTM domain", "go_ids": [], "go_terms": [], "name": "HTTM_dom", "pathway_ids": ["PWY-7999", "R-HSA-159740", "R-HSA-9673240", "R-MMU-159740", "R-RNO-159740", "R-BTA-159740"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-9673240:r:Defective gamma-carboxylation of F9", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-BTA-159740:r:Gamma-carboxylation of protein precursors"], "type": "Domain"}, "IPR053935": {"description": "Vitamin K-dependent gamma-carboxylase, lumenal domain", "go_ids": [], "go_terms": [], "name": "VKGC_lumenal_dom", "pathway_ids": ["PWY-7999", "R-HSA-159740", "R-HSA-9673240", "R-MMU-159740", "R-RNO-159740", "R-BTA-159740"], "pathways": ["PWY-7999:t:vitamin K-epoxide cycle", "R-HSA-159740:r:Gamma-carboxylation of protein precursors", "R-HSA-9673240:r:Defective gamma-carboxylation of F9", "R-MMU-159740:r:Gamma-carboxylation of protein precursors", "R-RNO-159740:r:Gamma-carboxylation of protein precursors", "R-BTA-159740:r:Gamma-carboxylation of protein precursors"], "type": "Domain"}, "IPR053936": {"description": "Wntless, GOLD domain", "go_ids": [], "go_terms": [], "name": "WLS_GOLD", "pathway_ids": ["R-RNO-3238698", "R-MMU-3238698", "R-CEL-3238698", "R-DME-3238698", "R-HSA-3238698"], "pathways": ["R-RNO-3238698:r:WNT ligand biogenesis and trafficking", "R-MMU-3238698:r:WNT ligand biogenesis and trafficking", "R-CEL-3238698:r:WNT ligand biogenesis and trafficking", "R-DME-3238698:r:WNT ligand biogenesis and trafficking", "R-HSA-3238698:r:WNT ligand biogenesis and trafficking"], "type": "Domain"}, "IPR053937": {"description": "GOST, seven transmembrane domain", "go_ids": [], "go_terms": [], "name": "GOST_TM", "pathway_ids": ["R-HSA-8980692", "R-MMU-8980692"], "pathways": ["R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Domain"}, "IPR053938": {"description": "PTM1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PTM1-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053939": {"description": "UTP25, C-terminal domain", "go_ids": [], "go_terms": [], "name": "UTP25_C", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR053940": {"description": "UTP25, NTP hydrolase-like domain", "go_ids": [], "go_terms": [], "name": "UTP25_NTPase-like", "pathway_ids": ["R-MMU-6791226", "R-XTR-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-XTR-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR053941": {"description": "Csm6, HEPN domain", "go_ids": [], "go_terms": [], "name": "Csm6_HEPN", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053944": {"description": "Shieldin complex subunit 2, second OB fold domain", "go_ids": [], "go_terms": [], "name": "SHLD2_OB2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053945": {"description": "Phosphoinositide phospholipase C beta 1-4-like, EF-hand domain", "go_ids": [], "go_terms": [], "name": "PLCB1-4-like_EFh", "pathway_ids": ["R-CEL-1855204", "R-HSA-434316", "R-HSA-418217", "R-MMU-112043", "R-MMU-500657", "R-BTA-434316", "R-BTA-399997", "R-RNO-112043", "R-BTA-500657", "R-BTA-416476", "R-BTA-1855204", "R-HSA-9717207", "R-MMU-418217", "R-CEL-112043", "R-DME-112043", "R-HSA-1855204", "R-MMU-399997", "R-RNO-1855204", "R-BTA-418217", "PWY-6367", "PWY-7039", "PWY-6351", "PWY-8052", "R-MMU-416476", "R-BTA-112043", "R-MMU-4086398", "R-HSA-416476", "R-HSA-399997", "R-CEL-416476", "R-RNO-399997", "R-HSA-112043", "R-HSA-500657", "R-BTA-4086398", "R-DME-1855204", "R-DME-416476", "R-HSA-4086398", "R-MMU-434316", "R-MMU-1855204", "R-RNO-416476", "R-RNO-434316"], "pathways": ["R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-HSA-418217:r:G beta:gamma signalling through PLC beta", "R-MMU-112043:r:PLC beta mediated events", "R-MMU-500657:r:Presynaptic function of Kainate receptors", "R-BTA-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-BTA-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-112043:r:PLC beta mediated events", "R-BTA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-416476:r:G alpha (q) signalling events", "R-BTA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-MMU-418217:r:G beta:gamma signalling through PLC beta", "R-CEL-112043:r:PLC beta mediated events", "R-DME-112043:r:PLC beta mediated events", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-399997:r:Acetylcholine regulates insulin secretion", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-BTA-418217:r:G beta:gamma signalling through PLC beta", "PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "R-MMU-416476:r:G alpha (q) signalling events", "R-BTA-112043:r:PLC beta mediated events", "R-MMU-4086398:r:Ca2+ pathway", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-399997:r:Acetylcholine regulates insulin secretion", "R-CEL-416476:r:G alpha (q) signalling events", "R-RNO-399997:r:Acetylcholine regulates insulin secretion", "R-HSA-112043:r:PLC beta mediated events", "R-HSA-500657:r:Presynaptic function of Kainate receptors", "R-BTA-4086398:r:Ca2+ pathway", "R-DME-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DME-416476:r:G alpha (q) signalling events", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-434316:r:Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"], "type": "Domain"}, "IPR053946": {"description": "YscD-like, Bon-like domain 3", "go_ids": [], "go_terms": [], "name": "YscD_ppl_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053947": {"description": "YscD-like, Bon-like domain 2", "go_ids": [], "go_terms": [], "name": "YscD_ppl__2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053948": {"description": "SBE2/SBE22, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SBE2/SBE22_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053949": {"description": "SBE2/SBE22, middle domain", "go_ids": [], "go_terms": [], "name": "SBE2/SBE22_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053950": {"description": "CAP, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CAP_N", "pathway_ids": ["R-DDI-6798695", "R-HSA-114608", "R-SPO-6798695", "R-HSA-6798695", "R-SCE-6798695", "R-MMU-6798695", "R-HSA-428890", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-114608:r:Platelet degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR053951": {"description": "K+ potassium transporter, integral membrane domain", "go_ids": [], "go_terms": [], "name": "K_trans_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053952": {"description": "K+ potassium transporter, C-terminal domain", "go_ids": [], "go_terms": [], "name": "K_trans_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053953": {"description": "Siroheme decarboxylase NirL-like, HTH domain", "go_ids": [], "go_terms": [], "name": "NirdL-like_HTH", "pathway_ids": ["PWY-7552", "PWY-7554"], "pathways": ["PWY-7552:t:heme b biosynthesis III (from siroheme)", "PWY-7554:t:heme d1 biosynthesis"], "type": "Domain"}, "IPR053954": {"description": "Domain of unknown function DUF7023", "go_ids": [], "go_terms": [], "name": "DUF7023", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053955": {"description": "Csm6, CARF domain", "go_ids": [], "go_terms": [], "name": "Csm6_CARF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR053956": {"description": "NPC1, middle luminal domain", "go_ids": [], "go_terms": [], "name": "NPC1_MLD", "pathway_ids": ["R-CEL-8963678", "R-HSA-8963678", "R-DME-8963678", "R-SCE-8963678", "R-MMU-8963678", "R-CEL-8964038", "R-MMU-8964038", "R-SCE-8964038", "R-RNO-8963678", "R-HSA-8964038"], "pathways": ["R-CEL-8963678:r:Intestinal lipid absorption", "R-HSA-8963678:r:Intestinal lipid absorption", "R-DME-8963678:r:Intestinal lipid absorption", "R-SCE-8963678:r:Intestinal lipid absorption", "R-MMU-8963678:r:Intestinal lipid absorption", "R-CEL-8964038:r:LDL clearance", "R-MMU-8964038:r:LDL clearance", "R-SCE-8964038:r:LDL clearance", "R-RNO-8963678:r:Intestinal lipid absorption", "R-HSA-8964038:r:LDL clearance"], "type": "Domain"}, "IPR053957": {"description": "DUF2089, zinc ribbon", "go_ids": [], "go_terms": [], "name": "DUF2089_Zn_ribbon", "pathway_ids": [], "pathways": 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[], "pathways": [], "type": "Domain"}, "IPR054042": {"description": "Dark, winged-helix domain", "go_ids": [], "go_terms": [], "name": "WHD_Dark", "pathway_ids": ["R-DME-9627069", "R-DME-111459", "R-DME-111458", "R-DME-6798695"], "pathways": ["R-DME-9627069:r:Regulation of the apoptosome activity", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-111458:r:Formation of apoptosome", "R-DME-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR054043": {"description": "Cell invasion protein SipA, C-terminal actin binding domain", "go_ids": [], "go_terms": [], "name": "SipA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054044": {"description": "Plasmid Fertility inhibition factor", "go_ids": [], "go_terms": [], "name": "PFIN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054045": {"description": "Mre11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Mre11_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054046": {"description": "Gycoside hydrolase/deacetylase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gyco_hydrolase/deacetylase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054047": {"description": "Gycoside hydrolase/deacetylase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Gyco_hydrolase/deacetylase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054048": {"description": "Glycoprotein M152, N-terminal domain", "go_ids": [], "go_terms": [], "name": "M152_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054049": {"description": "Sucrose hydrolase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SupH-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054050": {"description": "Mucin-like protein 1", "go_ids": [], "go_terms": [], "name": "MUCL1", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-913709", "R-HSA-977068", "R-HSA-5083625"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC"], "type": "Family"}, "IPR054051": {"description": "Mucin-20 repeat", "go_ids": [], "go_terms": [], "name": "MUC-20_rpt", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-8851805", "R-HSA-913709", "R-HSA-977068", "R-HSA-5083625"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC"], "type": "Repeat"}, "IPR054052": {"description": "Y16Q-like", "go_ids": [], "go_terms": [], "name": "Y16Q-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054053": {"description": "Protein of unknown function DUF6887", "go_ids": [], "go_terms": [], "name": "DUF6887", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054054": {"description": "New-glue 1-3-like", "go_ids": [], "go_terms": [], "name": "Ng_1-3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054055": {"description": "YpzH protein family", "go_ids": [], "go_terms": [], "name": "YpzH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054056": {"description": "ESX-1 secretion-associated protein EspB, PPE domain", "go_ids": [], "go_terms": [], "name": "EspB_PPE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054057": {"description": "Campylobacter invasion antigen D, C-terminal", "go_ids": [], "go_terms": [], "name": "CiaD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054058": {"description": "Helix-turn-helix family", "go_ids": [], "go_terms": [], "name": "HTH_67", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054059": {"description": "MORF/ORRM1/DAG-like, MORF domain", "go_ids": [], "go_terms": [], "name": "MORF/ORRM1/DAG-like_MORF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054060": {"description": "Talin 1-like, rod-segment domain", "go_ids": [], "go_terms": [], "name": "TLN1-like_RS", "pathway_ids": ["R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-9656223", "R-MMU-399955", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-DDI-114608", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR054061": {"description": "Domain of unknown function DUF6915", "go_ids": [], "go_terms": [], "name": "DUF6915", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054062": {"description": "Virion DNA-directed RNA polymerase domain 2", "go_ids": [], "go_terms": [], "name": "vRNAP_dom2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054063": {"description": "GlcNAc-binding protein A, third domain", "go_ids": [], "go_terms": [], "name": "GbpA_D3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054064": {"description": "Distal tail component, second carbohydrate binding domain", "go_ids": [], "go_terms": [], "name": "Dit-like_CBM2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054065": {"description": "Baseplate wedge protein gp6, C-terminal domain III", "go_ids": [], "go_terms": [], "name": "Gp6_C-III", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054066": {"description": "SAM domain-like", "go_ids": [], "go_terms": [], "name": "SAM_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054067": {"description": "SSO1120-like, N-terminal thioredoxin-like domain", "go_ids": [], "go_terms": [], "name": "SSO1120-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054068": {"description": "CofJ", "go_ids": [], "go_terms": [], "name": "CofJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054069": {"description": "Calpain-3/13-like, C-terminal EF-hand", "go_ids": [], "go_terms": [], "name": "CAPN3/13-like_C_EFh", "pathway_ids": ["R-HSA-1474228", "R-RNO-1474228", "R-MMU-1474228"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-RNO-1474228:r:Degradation of the extracellular matrix", "R-MMU-1474228:r:Degradation of the extracellular matrix"], "type": "Domain"}, "IPR054070": {"description": "C381 turret protein, middle domain", "go_ids": [], "go_terms": [], "name": "STIV_turret_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054071": {"description": "Neurofibromin, PH domain-like", "go_ids": [], "go_terms": [], "name": "PH_NF1", "pathway_ids": ["R-MMU-5658442", "R-RNO-5658442", "R-HSA-5658442", "R-HSA-6802953"], "pathways": ["R-MMU-5658442:r:Regulation of RAS by GAPs", "R-RNO-5658442:r:Regulation of RAS by GAPs", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-HSA-6802953:r:RAS signaling downstream of NF1 loss-of-function variants"], "type": "Domain"}, "IPR054072": {"description": "C381 turret protein, N-terminal", "go_ids": [], "go_terms": [], "name": "C381_turret_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054073": {"description": "C381 turret protein, C-terminal", "go_ids": [], "go_terms": [], "name": "C381_turret_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054074": {"description": "A223 penton protein, C-terminal", "go_ids": [], "go_terms": [], "name": "A223_penton_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054075": {"description": "Putative tail fiber protein gp53-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Gp53-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054076": {"description": "Zuotin-like, zuotin homology domain", "go_ids": [], "go_terms": [], "name": "ZUO1-like_ZHD", "pathway_ids": ["R-SCE-3371453", "R-XTR-3371453", "R-SPO-3371453", "R-RNO-3371453", "R-HSA-3371453", "R-DRE-3371453", "R-BTA-3371453", "R-MMU-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR054077": {"description": "TMEM181, GOLD domain", "go_ids": [], "go_terms": [], "name": "TMEM181_GOLD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054078": {"description": "BRF2-like, C-terminal", "go_ids": [], "go_terms": [], "name": "BRF2-like_C", "pathway_ids": ["R-MMU-76071", "R-HSA-76071", "R-BTA-76071", "R-DRE-76071", "R-RNO-76071", "R-HSA-749476"], "pathways": ["R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-DRE-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation"], "type": "Domain"}, "IPR054079": {"description": "RhiE, branching domain", "go_ids": [], "go_terms": [], "name": "RhiE_branching_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054080": {"description": "TPR1-like, CTLH-containing domain", "go_ids": [], "go_terms": [], "name": "TPR1-like_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054081": {"description": "Lin-28A-like, second zinc knuckle", "go_ids": [], "go_terms": [], "name": "Lin-28A-like_Znf-CCHC_2", "pathway_ids": ["R-HSA-452723"], "pathways": ["R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells"], "type": "Domain"}, "IPR054082": {"description": "Talin, IBS2B domain", "go_ids": [], "go_terms": [], "name": "Talin_IBS2B", "pathway_ids": ["R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-9656223", "R-MMU-399955", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-DDI-114608", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-DDI-114608:r:Platelet degranulation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR054083": {"description": "Sarcolamban A/B", "go_ids": [], "go_terms": [], "name": "SclA/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054084": {"description": "Tarsal-less AA", "go_ids": [], "go_terms": [], "name": "Tal-AA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054085": {"description": "Cep192-like, domain 1", "go_ids": [], "go_terms": [], "name": "Cep192-like_D1", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR054086": {"description": "Cep192-like, domain 2", "go_ids": [], "go_terms": [], "name": "Cep192-like_D2", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR054087": {"description": "Cep192-like, domain 7", "go_ids": [], "go_terms": [], "name": "Cep192-like_D7", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR054088": {"description": "Cep192-like, domain 8", "go_ids": [], "go_terms": [], "name": "Cep192-like_D8", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR054089": {"description": "Cep192-like, domain 3", "go_ids": [], "go_terms": [], "name": "Cep192-like_D3", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR054090": {"description": "Cep192/Spd-2-like domain", "go_ids": [], "go_terms": [], "name": "Cep192_Spd-2-like_dom", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR054091": {"description": "Cep192-like, domain 5", "go_ids": [], "go_terms": [], "name": "Cep192-like_D5", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the 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"Mannosylglycerate synthase, GT domain", "go_ids": [], "go_terms": [], "name": "MGS_GT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054146": {"description": "HOXB-AS3 peptide", "go_ids": [], "go_terms": [], "name": "HOXB-AS3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054147": {"description": "Transcriptional regulator PINT87aa", "go_ids": [], "go_terms": [], "name": "LINC-PINT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054148": {"description": "ASNSD1 upstream open reading frame protein", "go_ids": [], "go_terms": [], "name": "ASNSD1-SEP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054149": {"description": "Small integral membrane protein 43", "go_ids": [], "go_terms": [], "name": "SMIM43", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054150": {"description": "Transcriptional regulator SEHBP", "go_ids": [], "go_terms": [], "name": "SEHBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054151": {"description": "TR61B, FKBP-like domain", "go_ids": [], "go_terms": [], "name": "TR61B_FKBP-like", "pathway_ids": ["R-HSA-9937008", "R-HSA-6787450"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-HSA-6787450:r:tRNA modification in the mitochondrion"], "type": "Domain"}, "IPR054152": {"description": "YajR, YAM domain", "go_ids": [], "go_terms": [], "name": "YajR_YAM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054153": {"description": "Tailspike protein, galactose-binding domain-like", "go_ids": [], "go_terms": [], "name": "G7C_GBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054154": {"description": "Peroxisomal membrane protein PEX14, central, plants", "go_ids": [], "go_terms": [], "name": "PEX14-like_M_plants", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054155": {"description": "Cap-snatching endonuclease, N-terminal", "go_ids": [], "go_terms": [], "name": "CapSnatchArena_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054156": {"description": "Transcriptional regulator LmrA/YxaF-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YxaF_TetR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054157": {"description": "AGAO-like, N2 domain", "go_ids": [], "go_terms": [], "name": "AGAO-like_N2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054158": {"description": "B12-dependent ribonucleotide reductase, insertion domain", "go_ids": [], "go_terms": [], "name": "RNR-II_ins_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054159": {"description": "PTEN upstream open reading frame MP31", "go_ids": [], "go_terms": [], "name": "MP31", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054160": {"description": "MrkD-like, receptor binding domain", "go_ids": [], "go_terms": [], "name": "MrkD_recept-bd", "pathway_ids": ["R-HSA-9638630"], "pathways": ["R-HSA-9638630:r:Attachment of bacteria to epithelial cells"], "type": "Domain"}, "IPR054161": {"description": "Small regulatory polypeptide of amino acid response", "go_ids": [], "go_terms": [], "name": "SPAR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054162": {"description": "DUF6293, C-terminal winged helix domain", "go_ids": [], "go_terms": [], "name": "DUF6293_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054163": {"description": "LPP20 lipofamily protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HP1454-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054164": {"description": "Restriction endonuclease BpuSI, specificity domain", "go_ids": [], "go_terms": [], "name": "BpuSI_TRD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054165": {"description": "LPP20 lipofamily protein, middle domain", "go_ids": [], "go_terms": [], "name": "HP1454-like_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054166": {"description": "Tyrosine-protein kinase receptor torso, third FN3 domain", "go_ids": [], "go_terms": [], "name": "Tor_FN3_3nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054167": {"description": "Tyrosine-protein kinase receptor torso, first FN3 domain", "go_ids": [], "go_terms": [], "name": "Tor_FN3_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054168": {"description": "PG_1098 ferredoxin-like domain", "go_ids": [], "go_terms": [], "name": "PG_1098_Fer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054169": {"description": "1,4-alpha-glucan branching enzyme GlgB, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GlgB_N", "pathway_ids": ["PWY-622", "PWY-7900", "PWY-5067"], "pathways": ["PWY-622:t:starch biosynthesis", "PWY-7900:t:glycogen biosynthesis III (from alpha-maltose 1-phosphate)", "PWY-5067:t:glycogen biosynthesis II (from UDP-D-Glucose)"], "type": "Domain"}, "IPR054170": {"description": "RlmL, ferredoxin-like domain", "go_ids": [], "go_terms": [], "name": "RlmL_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054171": {"description": "RbmA-like, FnIII domain", "go_ids": [], "go_terms": [], "name": "RbmA-like_FnIII", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054172": {"description": "Major capsid protein VP16-like", "go_ids": [], "go_terms": [], "name": "VP16-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054173": {"description": "ThiI, ferredoxin-like domain", "go_ids": [], "go_terms": [], "name": "ThiI_fer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054174": {"description": "Alpha-amylase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Alpha-amylase-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054175": {"description": "NS3 RNA helicase, C-terminal helical domain", "go_ids": [], "go_terms": [], "name": "NS3_helicase_C", "pathway_ids": ["PWY-7185", "PWY-7198", "PWY-6545", "PWY-7184", "PWY-7210", "R-HSA-8854214", "R-HSA-5621480"], "pathways": ["PWY-7185:t:UTP and CTP dephosphorylation I", "PWY-7198:t:pyrimidine deoxyribonucleotides de novo biosynthesis IV", "PWY-6545:t:pyrimidine deoxyribonucleotides de novo biosynthesis III", "PWY-7184:t:pyrimidine deoxyribonucleotides de novo biosynthesis I", "PWY-7210:t:pyrimidine deoxyribonucleotides biosynthesis from CTP", "R-HSA-8854214:r:TBC/RABGAPs", "R-HSA-5621480:r:Dectin-2 family"], "type": "Domain"}, "IPR054176": {"description": "Inner capsid protein lambda-1/VP3", "go_ids": [], "go_terms": [], "name": "Lamba1_VP3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054177": {"description": "Uncharacterized protein B-129, C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "B129_C2H2-Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054178": {"description": "Lpg0393-like, VPS9-like domain", "go_ids": [], "go_terms": [], "name": "Lpg0393-like_VPS9", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054179": {"description": "PSD13, N-terminal", "go_ids": [], "go_terms": [], "name": "PSD13_N", "pathway_ids": ["R-HSA-174178", "R-HSA-9604323", "R-RNO-5668541", "R-BTA-5689880", "R-HSA-8951664", "R-BTA-9755511", "R-HSA-9010553", "R-HSA-75815", "R-MMU-8948751", "R-SPO-5689880", "R-MMU-5689880", "R-BTA-1169091", "R-DDI-9929491", "R-GGA-68949", "R-BTA-69481", "R-RNO-8854050", "R-HSA-450408", "R-GGA-9766229", "R-RNO-450408", "R-SCE-5689880", "R-HSA-211733", "R-DDI-6798695", "R-DDI-174084", "R-HSA-5607761", "R-GGA-8948751", "R-MMU-9932298", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-GGA-9931269", "R-BTA-69017", "R-RNO-9954709", "R-HSA-180534", "R-BTA-4641257", "R-MMU-9766229", "R-RNO-69481", "R-DDI-187577", "R-BTA-349425", "R-GGA-187577", "R-HSA-174154", "R-RNO-1234176", "R-RNO-5632684", "R-RNO-9932298", "R-DDI-382556", "R-BTA-1236978", "R-MMU-187577", "R-GGA-9755511", "R-RNO-174178", "R-BTA-4608870", "R-BTA-5676590", "R-HSA-9824272", "R-MMU-174178", "R-MMU-349425", "R-GGA-1236978", "R-BTA-2871837", "R-HSA-9907900", "R-BTA-174154", "R-DDI-69601", "R-HSA-9762114", "R-DDI-5689880", "R-HSA-195253", "R-GGA-69601", "R-GGA-9929491", "R-BTA-187577", "R-RNO-9755511", "R-GGA-9020702", "R-RNO-174113", "R-BTA-9929356", "R-GGA-9954709", "R-MMU-5676590", "R-GGA-5689880", "R-RNO-187577", "R-MMU-174184", "R-RNO-68867", "R-RNO-350562", "R-RNO-9762114", "R-GGA-69017", "R-BTA-9954709", "R-RNO-69017", "R-HSA-5358346", "R-SPO-350562", "R-HSA-6798695", "R-MMU-5632684", "R-RNO-9020702", "R-GGA-450408", "R-BTA-5610785", "R-SPO-9907900", "R-BTA-202424", "R-MMU-2467813", "R-HSA-9932298", "R-BTA-6798695", "R-DDI-1236978", "R-DDI-8951664", "R-GGA-382556", "R-GGA-8854050", "R-GGA-9932298", "R-MMU-8951664", "R-RNO-174154", "R-MMU-9929356", "R-SCE-5668541", "R-RNO-9929356", "R-HSA-69481", "R-BTA-174084", "R-BTA-5687128", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-HSA-4641258", "R-RNO-8939236", "R-SPO-5689603", "R-HSA-180585", "R-SPO-1236978", "R-RNO-174184", "R-GGA-68867", "R-BTA-4641258", "R-HSA-4608870", "R-MMU-4641257", "R-MMU-6798695", "R-RNO-2467813", "R-SPO-6798695", "R-MMU-5610780", "R-BTA-382556", "R-GGA-350562", "R-MMU-9755511", "R-MMU-9954709", "R-DDI-75815", "R-GGA-174154", "R-RNO-5689603", "R-HSA-2871837", "R-RNO-5610780", "R-GGA-8939236", "R-GGA-8939902", "R-HSA-5362768", "R-DDI-9954709", "R-MMU-5658442", "R-RNO-8852276", "R-GGA-5668541", "R-GGA-2467813", "R-HSA-174084", "R-MMU-4608870", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-RNO-9907900", "R-BTA-8948751", "R-RNO-9929491", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-BTA-5689603", "R-DDI-349425", "R-RNO-8941858", "R-RNO-5607764", "R-RNO-1169091", "R-HSA-69017", "R-BTA-9020702", "R-RNO-9766229", "R-BTA-5607764", "R-DDI-450408", "R-MMU-1236978", "R-GGA-5610780", "R-HSA-202424", "R-GGA-75815", "R-DDI-174154", "R-RNO-2871837", "R-MMU-450408", "R-RNO-68949", "R-GGA-5689603", "R-HSA-9020702", "R-RNO-8948751", "R-MMU-8941858", "R-HSA-5689880", "R-BTA-1234176", "R-MMU-174154", "R-MMU-69017", "R-MMU-9020702", "R-RNO-382556", "R-RNO-5687128", "R-MMU-69481", "R-BTA-350562", "R-MMU-75815", "R-BTA-75815", "R-MMU-5668541", "R-BTA-69601", "R-HSA-8854050", "R-BTA-5607761", "R-GGA-5658442", "R-HSA-5610783", "R-GGA-5632684", "R-MMU-174084", "R-BTA-68867", "R-HSA-1234176", "R-RNO-4641258", "R-HSA-9931269", "R-MMU-68867", "R-HSA-9929491", "R-RNO-5689880", "R-RNO-8951664", "R-GGA-195253", "R-HSA-1236974", "R-MMU-5687128", "R-RNO-5358346", "R-RNO-6798695", "R-GGA-983168", "R-HSA-68949", "R-HSA-5610785", "R-RNO-5676590", "R-HSA-2467813", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-RNO-69601", "R-GGA-8951664", "R-GGA-5607764", "R-GGA-2871837", "R-GGA-5610785", "R-MMU-8939236", "R-RNO-4641257", "R-GGA-8941858", "R-DDI-5689603", "R-GGA-9907900", "R-DDI-2467813", "R-RNO-349425", "R-GGA-349425", "R-BTA-174184", "R-MMU-9762114", "R-MMU-195253", "R-MMU-202424", "R-BTA-8939236", "R-MMU-382556", "R-HSA-5610780", "R-BTA-5632684", "R-DDI-5687128", "R-BTA-9931269", "R-DDI-9907900", "R-SCE-1236978", "R-RNO-75815", "R-MMU-1169091", "R-MMU-5607761", "R-HSA-8939902", "R-MMU-8939902", "R-GGA-1169091", "R-GGA-9929356", "R-RNO-195253", "R-HSA-8939236", "R-DDI-8854050", "R-BTA-983168", "R-GGA-4608870", "R-MMU-5607764", "R-BTA-5668541", "R-GGA-1234176", "R-GGA-5358346", "R-HSA-9766229", "R-HSA-5676590", "R-DDI-5632684", "R-BTA-9929491", "R-GGA-5687128", "R-HSA-4641257", "R-RNO-202424", "R-BTA-9932298", "R-MMU-9929491", "R-BTA-9762114", "R-HSA-174113", "R-RNO-5607761", "R-GGA-4641257", "R-HSA-68867", "R-MMU-9907900", "R-DDI-5658442", "R-BTA-450408", "R-HSA-8941858", "R-HSA-9755511", "R-RNO-9931269", "R-GGA-6798695", "R-HSA-1169091", "R-GGA-174178", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-9931269", "R-DDI-68949", "R-RNO-174084", "R-HSA-8948751", "R-HSA-5689603", "R-RNO-983168", "R-GGA-174084", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-HSA-187577", "R-DDI-9755511", "R-GGA-4641258", "R-BTA-8941858", "R-HSA-349425", "R-HSA-174184", "R-MMU-350562", "R-MMU-69601", "R-BTA-2467813", "R-MMU-5610785", "R-GGA-202424", "R-HSA-9954709", "R-MMU-5358346", "R-MMU-8854050", "R-MMU-5689603", "R-HSA-5607764", "R-RNO-1236978", "R-RNO-4608870", "R-HSA-382556", "R-HSA-8852276", "R-GGA-174184", "R-SCE-9907900", "R-DDI-983168", "R-HSA-5668541", "R-HSA-9929356", "R-HSA-5687128", "R-RNO-5658442", "R-RNO-5610785", "R-MMU-983168", "R-GGA-9762114", "R-HSA-350562", "R-DDI-174178"], "pathways": ["R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-68949:r:Orc1 removal from chromatin", "R-BTA-69481:r:G2/M Checkpoints", "R-RNO-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-GGA-9766229:r:Degradation of CDH1", "R-RNO-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-SCE-5689880:r:Ub-specific processing proteases", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-GGA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-GGA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-9766229:r:Degradation of CDH1", "R-RNO-69481:r:G2/M Checkpoints", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5632684:r:Hedgehog 'on' state", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-GGA-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-GGA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9907900:r:Proteasome assembly", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DDI-5689880:r:Ub-specific processing proteases", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-GGA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-GGA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-GGA-9020702:r:Interleukin-1 signaling", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-GGA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-5689880:r:Ub-specific processing proteases", "R-RNO-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-RNO-68867:r:Assembly of the pre-replicative complex", "R-RNO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-RNO-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-GGA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-5632684:r:Hedgehog 'on' state", "R-RNO-9020702:r:Interleukin-1 signaling", "R-GGA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-6798695:r:Neutrophil degranulation", 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quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Domain"}, "IPR054303": {"description": "Type III effector protein HopBA1", "go_ids": [], "go_terms": [], "name": "HopBA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054304": {"description": "Dark, CARD domain", "go_ids": [], "go_terms": [], "name": "Dark_CARD", "pathway_ids": ["R-DME-9627069", "R-DME-111459", "R-DME-111458", "R-DME-6798695"], "pathways": ["R-DME-9627069:r:Regulation of the apoptosome activity", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-111458:r:Formation of apoptosome", "R-DME-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR054305": {"description": "SwaI restriction 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{"description": "GNAT-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GNAT-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054342": {"description": "TY-Chap, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TY-Chap_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054343": {"description": "TY-Chap, central domain", "go_ids": [], "go_terms": [], "name": "TY-Chap_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054344": {"description": "TY-Chap, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TY-Chap_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054345": {"description": "Molecular chaperone Tir-like", "go_ids": [], "go_terms": [], "name": "Tir-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054346": {"description": "ARG and Rhodanese-Phosphatase-superfamily-associated domain 2", "go_ids": [], "go_terms": [], "name": "ARPP-2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054347": {"description": "TOTE conflict system, primase domain", "go_ids": [], "go_terms": [], "name": "TOTE_primase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054348": {"description": "Protein M, C-terminal", "go_ids": [], "go_terms": [], "name": "M_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054349": {"description": "Protein M, smaller domain", "go_ids": [], "go_terms": [], "name": "M_smaller_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054350": {"description": "PurT/PurK-like, preATP-grasp domain", "go_ids": [], "go_terms": [], "name": "PurT/PurK_preATP-grasp", "pathway_ids": ["PWY-6122", "PWY-6277"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis"], "type": "Domain"}, "IPR054351": {"description": "NADH-ubiquinone oxidoreductase, ferredoxin-like domain", "go_ids": [], "go_terms": [], "name": 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biogenesis", "R-DDI-6799198:r:Complex I biogenesis", "R-DME-611105:r:Respiratory electron transport", "R-BTA-611105:r:Respiratory electron transport"], "type": "Domain"}, "IPR054352": {"description": "Aspartokinase, ACT domain", "go_ids": [], "go_terms": [], "name": "ACT_Aspartokinase", "pathway_ids": ["PWY-7977", "PWY-6562", "PWY-2942", "PWY-8088", "PWY-8296", "PWY-6559", "PWY-6160", "PWY-5097", "PWY-7153", "PWY-8179", "PWY-2941"], "pathways": ["PWY-7977:t:L-methionine biosynthesis IV", "PWY-6562:t:norspermidine biosynthesis", "PWY-2942:t:L-lysine biosynthesis III", "PWY-8088:t:dipicolinate biosynthesis", "PWY-8296:t:cremeomycin biosynthesis", "PWY-6559:t:spermidine biosynthesis II", "PWY-6160:t:3-dehydroquinate biosynthesis II (archaea)", "PWY-5097:t:L-lysine biosynthesis VI", "PWY-7153:t:grixazone biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-2941:t:L-lysine biosynthesis II"], "type": "Domain"}, "IPR054353": {"description": "Transposase for insertion sequence element IS21-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "IstA-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054354": {"description": "Dynein 2 heavy chain 1, cytoplasmic, ATPase lid domain", "go_ids": [], "go_terms": [], "name": "DYNC2H1-like_lid", "pathway_ids": ["R-HSA-6798695", "R-HSA-9646399", "R-DME-3371497", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-380284", "R-DDI-9646399", "R-RNO-5610787", "R-MMU-68877", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-HSA-380320", "R-MMU-5610787", "R-RNO-380284", "R-MMU-5620912", "R-DME-6807878", "R-MMU-5620924", "R-DDI-6798695", "R-HSA-5620924", "R-MMU-141444", "R-MMU-380259", "R-PFA-9646399", "R-HSA-141444", "R-CEL-6807878", "R-MMU-380270", "R-HSA-9648025", "R-HSA-9609690", "R-RNO-5663220", "R-CEL-5620924", "R-MMU-6811436", "R-RNO-6811436", "R-MMU-9646399", "R-MMU-8854518", "R-MMU-6798695", "R-RNO-2467813", "R-RNO-5620924", "R-RNO-380270", "R-RNO-6798695", "R-RNO-141444", "R-MMU-5663220", 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"R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-2132295:r:MHC class II antigen presentation", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-PFA-3371497:r:HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-RNO-2132295:r:MHC class II antigen presentation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DME-9646399:r:Aggrephagy", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-DDI-6807878:r:COPI-mediated anterograde transport", "R-PFA-6798695:r:Neutrophil degranulation", "R-RNO-9646399:r:Aggrephagy", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes"], "type": "Domain"}, "IPR054355": {"description": "Decaheme cytochrome c component MtrF-like, domain III", "go_ids": [], "go_terms": [], "name": "MtrF-like_dom_III", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054356": {"description": "Peptidoglycan muramidase Tse3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Tse3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054357": {"description": "Peroxisomal multifunctional enzyme type 2-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MFE-2_N", "pathway_ids": ["PWY-6944", "PWY-6920", "PWY-7288", "PWY-7339", "PWY-5138", "PWY-8152", "PWY-5972", "PWY-7338", "PWY-7340", "PWY-6657", "PWY-7337", "R-MMU-2046106", "R-MMU-193368", "R-DDI-390247", "R-DDI-2046106", "R-DME-9033241", "R-DME-389887", "R-RNO-2046106", "R-HSA-389887", "R-HSA-193368", "R-MMU-9033241", "R-DME-2046106", "R-RNO-9033241", "R-MMU-389887", "R-DME-193368", "R-RNO-389887", "R-DDI-389887", "R-DDI-193368", "R-HSA-390247", "R-MMU-390247", "R-RNO-193368", "R-HSA-9033500", "R-DME-390247", "R-HSA-2046106", "R-DDI-9033241", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-5138:t:fatty acid beta-oxidation IV (unsaturated, even number)", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DDI-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-9033241:r:Peroxisomal protein import", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-9033241:r:Peroxisomal protein import", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-389887:r:Beta-oxidation of pristanoyl-CoA", "R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR054358": {"description": "Magnetotaxis protein MtxA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MtxA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054359": {"description": "Magnetotaxis protein MtxA, middle immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "MtxA_M_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054360": {"description": "Internalin K, domain D2", "go_ids": [], "go_terms": [], "name": "InlK_D2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054361": {"description": "Zinc finger CCCH domain-containing protein 4/6/8, CCCH zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-CCCH_ZC3H4/6/8", "pathway_ids": ["R-MMU-9930044", "R-MMU-6807505", "R-HSA-9930044", "R-HSA-6807505"], "pathways": ["R-MMU-9930044:r:Nuclear RNA decay", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-9930044:r:Nuclear RNA decay", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR054362": {"description": "Exuperantia RNAse H-like domain", "go_ids": [], "go_terms": [], "name": "Exu_RNase_H-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054363": {"description": "Glycosyl hydrolase family 95, catalytic domain", "go_ids": [], "go_terms": [], "name": "GH95_cat", "pathway_ids": ["PWY-6807"], "pathways": ["PWY-6807:t:xyloglucan degradation II (exoglucanase)"], "type": "Domain"}, "IPR054364": {"description": "Ca3427-like, PBP 2", "go_ids": [], "go_terms": [], "name": "Ca3427-like_PBP2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054365": {"description": "Lreu_0056-like", "go_ids": [], "go_terms": [], "name": "Lreu_0056-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054366": {"description": "RepB/MobA-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RepB/MobA-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054367": {"description": "Oxo-glucose-6-phosphate:glutamate aminotransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NtdA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054368": {"description": "Alp7A-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Alp7A-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054369": {"description": "CRISPR-associated endonuclease Cas9, wedge domain", "go_ids": [], "go_terms": [], "name": "Cas9_WED", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054370": {"description": "T4SS protein CagL-like", "go_ids": [], "go_terms": [], "name": "CagL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054371": {"description": "Exosome RNA binding protein RRP4, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RRP4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054372": {"description": "Gp38-like", "go_ids": [], "go_terms": [], "name": "Gp38-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054373": {"description": "CRISPR-associated endonuclease Cas9, PI domain, C-terminal, campylobacterales", "go_ids": [], "go_terms": [], "name": "Cas9_PI_C_campylobact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054374": {"description": "AF1548-like, C-terminal", "go_ids": [], "go_terms": [], "name": "AF1548-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054375": {"description": "MrkH-like, YcgR-like domain", "go_ids": [], "go_terms": [], "name": "MrkH_YcgR-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054376": {"description": "CdsD, periplasmic PD2 domain", "go_ids": [], "go_terms": [], "name": "CdsD_PD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054377": {"description": "tRNA(Ile)-lysidine synthase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TilS-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054378": {"description": "Type VI lipoprotein IgE-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "IgE-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054379": {"description": "Non-toxic nonhaemagglutinin, helical domain", "go_ids": [], "go_terms": [], "name": "NTNH_H", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054380": {"description": "BA_2335-like", "go_ids": [], "go_terms": [], "name": "BA_2335-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054381": {"description": "CydS-like", "go_ids": [], "go_terms": [], "name": "CydS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054382": {"description": "Winged helix domain, alphaproteobacteria", "go_ids": [], "go_terms": [], "name": "wHTH_alphaproteobact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054383": {"description": "PspA associated protein B-like", "go_ids": [], "go_terms": [], "name": "PspAB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054384": {"description": "SecDF, P1 head subdomain", "go_ids": [], "go_terms": [], "name": "SecDF_P1_head", "pathway_ids": ["R-HSA-1222387"], "pathways": ["R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Domain"}, "IPR054385": {"description": "Anti-restriction endonuclease", "go_ids": [], "go_terms": [], "name": "Arn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054386": {"description": "RIM, zinc finger", "go_ids": [], "go_terms": [], "name": "RIM_Znf", "pathway_ids": ["R-HSA-181430", "R-MMU-212676", "R-CEL-181430", "R-RNO-181430", "R-MMU-888590", "R-RNO-210500", "R-MMU-181430", "R-CEL-210500", "R-MMU-210500", "R-HSA-264642", "R-MMU-181429", "R-CEL-212676", "R-CEL-888590", "R-MMU-264642", "R-HSA-888590", "R-HSA-181429", "R-RNO-212676", "R-RNO-264642", "R-CEL-181429", "R-RNO-181429", "R-CEL-264642", "R-HSA-212676", "R-HSA-210500", "R-RNO-888590"], "pathways": ["R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-888590:r:GABA synthesis, release, reuptake and degradation", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-CEL-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-212676:r:Dopamine Neurotransmitter Release Cycle", "R-CEL-888590:r:GABA synthesis, release, reuptake and degradation", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-888590:r:GABA synthesis, release, reuptake and degradation", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-CEL-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-CEL-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-888590:r:GABA synthesis, release, reuptake and degradation"], "type": "Domain"}, "IPR054387": {"description": "Argonaute, N-terminal domain, bacteria", "go_ids": [], "go_terms": [], "name": "Ago_N_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054388": {"description": "T6SS, Phospholipase effector Tle1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tle1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054390": {"description": "Argonaute, N-terminal domain, archaea", "go_ids": [], "go_terms": [], "name": "Ago_N_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054391": {"description": "DNA repair helicase XPD, arch domain", "go_ids": [], "go_terms": [], "name": "XPD_arch", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054392": {"description": "VipD-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "VipD-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054393": {"description": "Thiaminase-1, insert domain", "go_ids": [], "go_terms": [], "name": "Thiaminase-1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054394": {"description": "Hydroxylamine oxidoreductase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Hao_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054395": {"description": "Capsid protein, C-terminal domain, fungal virus", "go_ids": [], "go_terms": [], "name": "P2_C_fungal_virus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054396": {"description": "GtfA, extended beta-sheet meander domain", "go_ids": [], "go_terms": [], "name": "GtfA_EBD", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR054397": {"description": "LicP, N-terminal prodomain", "go_ids": [], "go_terms": [], "name": "LicP_N_prodom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054398": {"description": "AcrIC5-like domain", "go_ids": [], "go_terms": [], "name": "AcrIC5-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054399": {"description": "Fervidolysin-like, N-terminal prodomain", "go_ids": [], "go_terms": [], "name": "Fervidolysin-like_N_prodom", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR054400": {"description": "Fervidolysin, second beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Fervidolysin_SD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054401": {"description": "Type IV pilin Tt1219-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Tt1219-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054402": {"description": "Type IV pilin Tt1218-like domain", "go_ids": [], "go_terms": [], "name": "Tt1218-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054403": {"description": "RNA-dependent RNA polymerase, palm domain, ribovirus", "go_ids": [], "go_terms": [], "name": "RdRp_palm_ribovirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054404": {"description": "Elongation factor SelB, first winged-helix domain", "go_ids": [], "go_terms": [], "name": "SelB_WH1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054405": {"description": "Elongation factor SelB, second winged-helix domain", "go_ids": [], "go_terms": [], "name": "SelB_WH2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054406": {"description": "Mre11, accessory DNA binding capping domain", "go_ids": [], "go_terms": [], "name": "Mre11_acc_DNA_cap", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054407": {"description": "Thiaminase I-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Thiaminase_I-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054409": {"description": "Amylopullulanase, X25 domain", "go_ids": [], "go_terms": [], "name": "X25_BaPul-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054410": {"description": "ORF239-like", "go_ids": [], "go_terms": [], "name": "ORF239-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054411": {"description": "BVU_2266-like", "go_ids": [], "go_terms": [], "name": "BVU_2266-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054412": {"description": "GndA domain", "go_ids": [], "go_terms": [], "name": "GndA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054413": {"description": "LSO1/LSO2", "go_ids": [], "go_terms": [], "name": "LSO1/2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054414": {"description": "Coiled-coil domain-containing protein 124/Oxs1, C-terminal", "go_ids": [], "go_terms": [], "name": "Ccdc124/Oxs1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054415": {"description": "Sporulation protein 24", "go_ids": [], "go_terms": [], "name": "SPO24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054416": {"description": "Glutathione S-transferase UstS-like , C-terminal domain", "go_ids": [], "go_terms": [], "name": "GST_UstS-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054417": {"description": "Secreted glycosylated protein U9-ORF", "go_ids": [], "go_terms": [], "name": "U9-ORF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054418": {"description": "Aminodeoxyfutalosine deaminase/Imidazolonepropionase-like, composite domain, N-terminal", "go_ids": [], "go_terms": [], "name": "MQNX/HUTI_composite_N", "pathway_ids": ["PWY-5030", "PWY-5028"], "pathways": ["PWY-5030:t:L-histidine degradation III", "PWY-5028:t:L-histidine degradation II"], "type": "Domain"}, "IPR054419": {"description": "NSF, AAA+ ATPase lid domain", "go_ids": [], "go_terms": [], "name": "NSF_ATPase_lid", "pathway_ids": ["R-MMU-204005", "R-HSA-416993", "R-DME-416993", "R-HSA-6811438", "R-MMU-6811438", "R-DME-6811440", "R-RNO-6811440", "R-RNO-6811434", "R-RNO-6807878", "R-RNO-6811438", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-HSA-6811440", "R-DME-6811438", "R-RNO-204005", "R-MMU-6811440", "R-HSA-204005", "R-DME-6811434", "R-CEL-6811440", "R-HSA-6811434", "R-DME-204005", "R-CEL-204005", "R-CEL-6811438", "R-DME-6807878", "R-MMU-416993", "R-CEL-6811434", "R-RNO-416993", "R-MMU-6811434"], "pathways": ["R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-DME-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-DME-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-DME-6811438:r:Intra-Golgi traffic", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-MMU-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-CEL-6811440:r:Retrograde transport at the Trans-Golgi-Network", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-DME-204005:r:COPII-mediated vesicle transport", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-MMU-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-416993:r:Trafficking of GluR2-containing AMPA receptors", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR054420": {"description": "RAE1/2 domain I, C-terminal region", "go_ids": [], "go_terms": [], "name": "RAE1_2_domI_C", "pathway_ids": ["R-RNO-6803205", "R-MMU-6803205", "R-MMU-8876198", "R-RNO-8873719", "R-HSA-8873719", "R-RNO-8876198", "R-HSA-8876198", "R-HSA-6803205", "R-MMU-8873719"], "pathways": ["R-RNO-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-MMU-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-8873719:r:RAB geranylgeranylation", "R-HSA-8873719:r:RAB geranylgeranylation", "R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-6803205:r:TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-MMU-8873719:r:RAB geranylgeranylation"], "type": "Domain"}, "IPR054421": {"description": "McpB, second HAMP domain", "go_ids": [], "go_terms": [], "name": "McpB_HAMP_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054422": {"description": "Tetracyclin repressor-like HI_0893, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TetR-like_HI_0893_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054423": {"description": "Replitron, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Replitron_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054424": {"description": "Replitron, HUH endonuclease domain", "go_ids": [], "go_terms": [], "name": "Replitron_HUH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054425": {"description": "Cdc6/ORC1-like, ATPase lid domain", "go_ids": [], "go_terms": [], "name": "Cdc6_ORC1-like_ATPase_lid", "pathway_ids": ["R-SPO-176187", "R-HSA-68949", "R-SPO-68616", "R-HSA-69205", "R-MMU-68962", "R-MMU-69017", "R-MMU-68949", "R-SCE-69017", "R-HSA-68689", "R-SCE-68962", "R-PFA-68949", "R-HSA-1362277", "R-SPO-68689", "R-SCE-68689", "R-HSA-69017", "R-MMU-176187", "R-HSA-68962", "R-MMU-68689", "R-SPO-68962", "R-SPO-68949", "R-PFA-68616", "R-SCE-176187", "R-HSA-176187", "R-HSA-68867"], "pathways": ["R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-69205:r:G1/S-Specific Transcription", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-68949:r:Orc1 removal from chromatin", "R-SCE-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-PFA-68949:r:Orc1 removal from chromatin", "R-HSA-1362277:r:Transcription of E2F targets under negative control by DREAM complex", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SPO-68949:r:Orc1 removal from chromatin", "R-PFA-68616:r:Assembly of the ORC complex at the origin of replication", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR054426": {"description": "TOTE conflict systems, S1/CSD-like domain 1", "go_ids": [], "go_terms": [], "name": "S1CSD-TOTE-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054427": {"description": "TOTE conflict systems, S1/CSD-like domain 2", "go_ids": [], "go_terms": [], "name": "S1CSD-TOTE-2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054428": {"description": "TMADH/DMDH/HD, second alpha/beta domain", "go_ids": [], "go_terms": [], "name": "TMADH/DMDH/HD_second_a-b", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054429": {"description": "Muscleblind-like, CCCH zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-CCCH_Muscleblind-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054430": {"description": "Baseplate wedge protein gp10, domain 3", "go_ids": [], "go_terms": [], "name": "Gp10_D3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054433": {"description": "RNA-dependent RNA polymerase, thumb domain, ribovirus", "go_ids": [], "go_terms": [], "name": "RdRp_thumb_ribovirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054434": {"description": "Argonaute, middle domain, bacteria", "go_ids": [], "go_terms": [], "name": "Ago_MID_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054436": {"description": "Argonaute, PAZ domain, methanocaldococcus", "go_ids": [], "go_terms": [], "name": "Ago_PAZ_methanocaldococcus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054437": {"description": "PspA-associated domain", "go_ids": [], "go_terms": [], "name": "PspA-assoc_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054438": {"description": "Structural cement protein E217 gp24/Pam3 gp6", "go_ids": [], "go_terms": [], "name": "Struct_cement_gp24/gp6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054440": {"description": "Tail fiber protein gp32-like", "go_ids": [], "go_terms": [], "name": "Gp32-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054441": {"description": "Collar protein gp28-like", "go_ids": [], "go_terms": [], "name": "Gp28-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054442": {"description": "E217 Baseplate component gp38-like", "go_ids": [], "go_terms": [], "name": "E217_Gp38-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054443": {"description": "Glycan binding protein Y3-like domain", "go_ids": [], "go_terms": [], "name": "Y3-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054444": {"description": "YoaL-like", "go_ids": [], "go_terms": [], "name": "YoaL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054445": {"description": "T3SS, peptide-binding chaperone domain", "go_ids": [], "go_terms": [], "name": "T3SS_chaperone_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054446": {"description": "CIMIP3-like", "go_ids": [], "go_terms": [], "name": "CIMIP3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054447": {"description": "Gateway protein gp29-like", "go_ids": [], "go_terms": [], "name": "Gp29-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054448": {"description": "Helix-turn-helix domain, putative, ascomycetes", "go_ids": [], "go_terms": [], "name": "HTH_put_ascomycetes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054449": {"description": "Nonstructural protein, WIV domain", "go_ids": [], "go_terms": [], "name": "WIV_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054450": {"description": "TIL-like domain", "go_ids": [], "go_terms": [], "name": "TIL-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054451": {"description": "RhopH3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RhopH3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054452": {"description": "Minimal SLOG domain", "go_ids": [], "go_terms": [], "name": "mSLOG_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054453": {"description": "PssL-like", "go_ids": [], "go_terms": [], "name": "PssL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054454": {"description": "NGO_1070-like", "go_ids": [], "go_terms": [], "name": "NGO_1070-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054455": {"description": "TraH, VirB8-like domain", "go_ids": [], "go_terms": [], "name": "TraH_VirB8-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054456": {"description": "Replication initiation protein, N-terminal", "go_ids": [], "go_terms": [], "name": "RepD-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054457": {"description": "Phage phiCb5, coat protein", "go_ids": [], "go_terms": [], "name": "PhiCb5_coat", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054458": {"description": "Conserved flagellar protein F, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "FlaF_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054459": {"description": "Transcriptional cofactor Bfc domain", "go_ids": [], "go_terms": [], "name": "Bfc_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054460": {"description": "DUF5018-related", "go_ids": [], "go_terms": [], "name": "DUF5018-rel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054461": {"description": "TraI-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TraI-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054462": {"description": "TraI-like, middle domain", "go_ids": [], "go_terms": [], "name": "TraI_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054463": {"description": "RxLR effector PexRD54, WY domain", "go_ids": [], "go_terms": [], "name": "PexRD54_WY", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054464": {"description": "Ubiquitin-like domain, fungal", "go_ids": [], "go_terms": [], "name": "ULD_fung", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054465": {"description": "Integrase p58-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Integrase_p58-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054466": {"description": "Kinase OspG, kinase domain", "go_ids": [], "go_terms": [], "name": "OspG_kinase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054467": {"description": "YkoP-like domain", "go_ids": [], "go_terms": [], "name": "YkoP-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054468": {"description": "NrS-1 polymerase-like, HBD domain", "go_ids": [], "go_terms": [], "name": "NrSPol-like_HBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054469": {"description": "Predicted hydrolase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Pred_hydrolase_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054470": {"description": "FIMAH domain", "go_ids": [], "go_terms": [], "name": "FIMAH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054471": {"description": "GPI inositol-deacylase, winged helix domain", "go_ids": [], "go_terms": [], "name": "GPIID_WHD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054472": {"description": "Winged helix domain, variant", "go_ids": [], "go_terms": [], "name": "WHD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054473": {"description": "Kinesin-like protein KIF2A-like, N-terminal", "go_ids": [], "go_terms": [], "name": "KIF2A-like_N", "pathway_ids": ["R-HSA-2132295", "R-HSA-2467813", "R-RNO-983189", "R-RNO-2500257", "R-MMU-2467813", "R-MMU-983189", "R-MMU-68877", "R-DME-983189", "R-HSA-6811434", "R-HSA-68877", "R-MMU-2132295", "R-MMU-9648025", "R-MMU-6811434", "R-MMU-2500257", "R-RNO-2132295", "R-RNO-68877", "R-HSA-2500257", "R-MMU-141444", "R-RNO-6811434", "R-HSA-141444", "R-HSA-9648025", "R-RNO-5663220", "R-HSA-983189", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-MMU-5663220", "R-RNO-141444"], "pathways": ["R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-983189:r:Kinesins", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-983189:r:Kinesins", "R-MMU-68877:r:Mitotic Prometaphase", "R-DME-983189:r:Kinesins", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-2132295:r:MHC class II antigen presentation", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-HSA-983189:r:Kinesins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "type": "Domain"}, "IPR054474": {"description": "Diacylglycerol kinase eta/delta/kappa, helical domain", "go_ids": [], "go_terms": [], "name": "DGKD_4H", "pathway_ids": ["PWY-7039", "PWY-7817", "R-MMU-114508", "R-HSA-114508", "R-DME-114508"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-DME-114508:r:Effects of PIP2 hydrolysis"], "type": "Domain"}, "IPR054475": {"description": "DNA polymerase-epsilon, zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf-DPOE", "pathway_ids": ["R-DDI-6782135", "R-DME-110314", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656169", "R-HSA-5696397", "R-DDI-6782210", "R-MMU-110314", "R-DDI-68952", "R-DME-68962", "R-DDI-68962", "R-HSA-68962", "R-HSA-6782210", "R-DME-68952", "R-HSA-5656169", "R-DME-6782135", "R-SCE-68952", "R-MMU-5696400", "R-SPO-5696397", "R-DME-5651801", "R-HSA-68952", "R-MMU-68962", "R-MMU-5651801", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-SCE-68962", "R-MMU-68952", "R-DME-5656169", "R-SPO-5696400", "R-SPO-68952", "R-DME-5696400", "R-SPO-6782210", "R-SPO-110314", "R-SPO-68962", "R-HSA-5696400", "R-HSA-110314", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-SCE-6782135", "R-SPO-5651801"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-68952:r:DNA replication initiation", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-68952:r:DNA replication initiation", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-68952:r:DNA replication initiation", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-MMU-68952:r:DNA replication initiation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-68952:r:DNA replication initiation", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Domain"}, "IPR054476": {"description": "E3 ubiquitin-protein ligase listerin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ltn1_N", "pathway_ids": ["PWY-7511", "R-SPO-9954709", "R-DDI-983168", "R-DME-983168", "R-DME-9954709", "R-CEL-9954709", "R-HSA-9954709", "R-MMU-983168", "R-SPO-983168", "R-DDI-9954709", "R-MMU-9954709", "R-SCE-9954709", "R-HSA-983168", "R-SCE-983168", "R-CEL-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR054477": {"description": "E3 ubiquitin-protein ligase listerin, HEAT repeat region", "go_ids": [], "go_terms": [], "name": "LTN1_E3_ligase_6th", "pathway_ids": ["PWY-7511", "R-SPO-9954709", "R-DDI-983168", "R-DME-983168", "R-DME-9954709", "R-HSA-9954709", "R-MMU-983168", "R-SPO-983168", "R-DDI-9954709", "R-SCE-9954709", "R-HSA-983168", "R-SCE-983168", "R-MMU-9954709"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "type": "Domain"}, "IPR054478": {"description": "E3 ubiquitin-protein ligase listerin, ubiquitin conjugating domain", "go_ids": [], "go_terms": [], "name": "LTN1_UBC", "pathway_ids": ["PWY-7511", "R-SPO-9954709", "R-DDI-983168", "R-DME-983168", "R-DME-9954709", "R-CEL-9954709", "R-HSA-9954709", "R-MMU-983168", "R-SPO-983168", "R-DDI-9954709", "R-MMU-9954709", "R-SCE-9954709", "R-HSA-983168", "R-SCE-983168", "R-CEL-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR054479": {"description": "AglB-like, core domain", "go_ids": [], "go_terms": [], "name": "AglB-like_core", "pathway_ids": ["R-MMU-9931295", "R-BTA-9931295", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9918432", "R-BTA-9768727", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-9931295"], "pathways": ["R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-BTA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", 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"R-MMU-69481", "R-DME-5696394", "R-BTA-350562", "R-SPO-5689880", "R-DDI-8856825", "R-MMU-5689880", "R-MMU-75815", "R-BTA-75815", "R-BTA-1169091", "R-DDI-9929491", "R-BTA-69481", "R-BTA-69601", "R-MMU-5668541", "R-HSA-8854050", "R-MMU-5696394", "R-BTA-5607761", "R-HSA-450408", "R-CEL-5696394", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-BTA-68867", "R-HSA-1234176", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-DDI-174084", "R-MMU-68867", "R-MMU-9932298", "R-MMU-1234176", "R-RNO-5696394", "R-MMU-4641258", "R-DDI-4641258", "R-DDI-5696394", "R-RNO-8951664", "R-BTA-69017", "R-HSA-5696394", "R-HSA-180534", "R-HSA-1236974", "R-BTA-4641257", "R-MMU-5687128", "R-CEL-8856825", "R-MMU-9766229", "R-BTA-349425", "R-HSA-174154", "R-DDI-187577", "R-HSA-68949", "R-HSA-5610785", "R-BTA-1236978", "R-DDI-382556", "R-HSA-2467813", "R-MMU-187577", "R-BTA-195253", "R-MMU-8852276", "R-BTA-68949", "R-SCE-6798695", "R-MMU-68949", "R-HSA-9824272", "R-BTA-4608870", "R-BTA-5676590", "R-DDI-174178", "R-DDI-9013422", "R-MMU-174178", "R-MMU-349425", "R-MMU-8939236", "R-BTA-2871837", "R-HSA-9907900", "R-MMU-6781823", "R-BTA-174154", "R-BTA-6781823", "R-DDI-5689603", "R-DDI-69601", "R-DDI-2467813", "R-BTA-174184", "R-MMU-9762114", "R-HSA-9762114", "R-DRE-6781823", "R-DDI-5689880", "R-MMU-195253", "R-MMU-202424", "R-HSA-195253", "R-SSC-6781823", "R-HSA-5610780", "R-BTA-8939236", "R-BTA-5632684", "R-MMU-382556", "R-DDI-5687128", "R-BTA-187577", "R-BTA-9931269", "R-BTA-5696394", "R-DDI-9907900", "R-SCE-1236978", "R-MMU-1169091", "R-DME-9013422", "R-BTA-9929356", "R-MMU-5607761", "R-MMU-5676590", "R-BTA-9013422", "R-HSA-8939902", "R-MMU-174184", "R-MMU-8939902", "R-HSA-8856825", "R-BTA-9954709", "R-DRE-9013422", "R-HSA-8939236", "R-SPO-350562", "R-HSA-5358346", "R-CEL-8951664", "R-BTA-983168", "R-HSA-6798695", "R-DDI-8854050", "R-MMU-5632684", "R-HSA-9013422", "R-SPO-9907900", "R-BTA-5610785", "R-MMU-5607764", "R-BTA-202424", "R-MMU-2467813", "R-DME-6781823", "R-HSA-9932298", "R-DRE-8951664", "R-DME-8951664", "R-HSA-9766229", "R-BTA-5668541", "R-BTA-6798695", "R-HSA-5676590", "R-DDI-1236978", "R-DDI-5632684", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-8951664", "R-BTA-9929491", "R-MMU-9013422", "R-HSA-4641257", "R-BTA-9932298", "R-HSA-174113", "R-BTA-9762114", "R-MMU-9929356", "R-SSC-9013422", "R-MMU-9929491", "R-SCE-5668541", "R-HSA-68867", "R-MMU-9907900", "R-HSA-69481", "R-BTA-174084", "R-BTA-450408", "R-DDI-5658442", "R-BTA-5687128", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-BTA-5358346", "R-DDI-6781823", "R-HSA-9755511", "R-HSA-4641258", "R-DRE-5696394", "R-SPO-5689603", "R-CEL-6781823", "R-HSA-180585", "R-SPO-1236978", "R-BTA-4641258", "R-HSA-1169091", "R-HSA-4608870", "R-HSA-5658442", "R-BTA-8852276", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-BTA-8939902", "R-BTA-9766229", "R-BTA-8951664", "R-SPO-6798695", "R-HSA-187577", "R-MMU-5610780", "R-DDI-9755511", "R-BTA-382556", "R-MMU-8856825", "R-HSA-349425", "R-BTA-8941858", "R-MMU-9755511", "R-SSC-8951664", "R-HSA-174184", "R-MMU-350562", "R-DDI-75815", "R-MMU-9954709", "R-MMU-69601", "R-HSA-2871837", "R-BTA-2467813", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-SSC-8856825", "R-MMU-5658442", "R-MMU-5689603", "R-HSA-174084", "R-MMU-4608870", "R-HSA-5607764", "R-BTA-174178", "R-BTA-9907900", "R-DDI-69017", "R-BTA-5610780", "R-DRE-8856825", "R-DME-8856825", "R-BTA-8948751", "R-RNO-8856825", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-BTA-8854050", "R-SCE-9907900", "R-HSA-5668541", "R-BTA-5689603", "R-HSA-9929356", "R-BTA-8856825", "R-DDI-983168", "R-HSA-5687128", "R-DDI-349425", "R-HSA-69017", "R-BTA-9020702", "R-MMU-983168", "R-BTA-5607764", "R-DDI-450408", "R-MMU-1236978", "R-HSA-350562", "R-HSA-202424", "R-DDI-174154"], 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"R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-5689880:r:Ub-specific processing proteases", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-69481:r:G2/M Checkpoints", "R-BTA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-BTA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-8951664:r:Neddylation", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-HSA-1236974:r:ER-Phagosome pathway", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9766229:r:Degradation of CDH1", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-HSA-9824272:r:Somitogenesis", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-9907900:r:Proteasome assembly", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5689603:r:UCH proteinases", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-BTA-5632684:r:Hedgehog 'on' state", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-BTA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-CEL-8951664:r:Neddylation", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5632684:r:Hedgehog 'on' state", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-SPO-9907900:r:Proteasome assembly", "R-BTA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-202424:r:Downstream TCR signaling", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-DRE-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-BTA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-6798695:r:Neutrophil degranulation", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-4641257:r:Degradation of AXIN", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-SSC-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-HSA-69481:r:G2/M Checkpoints", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-4641258:r:Degradation of DVL", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-5689603:r:UCH proteinases", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5689603:r:UCH proteinases", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-BTA-8951664:r:Neddylation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-SSC-8951664:r:Neddylation", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-5689603:r:UCH proteinases", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-5689603:r:UCH proteinases", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", 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of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-432626:r:Circadian Clock pathway", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-RNO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-RNO-69231:r:Cyclin D associated events in G1", "R-MMU-389513:r:Co-inhibition by CTLA4", "R-DME-9833482:r:PKR-mediated signaling", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-198753:r:ERK/MAPK targets", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-195253:r:Degradation of beta-catenin by the destruction complex", "R-SSC-180024:r:DARPP-32 events", "R-SSC-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-9833482:r:PKR-mediated signaling", "R-DME-209155:r:Phosphorylation of AXN and APC", "R-SSC-198753:r:ERK/MAPK targets", "R-SSC-5663220:r:RHO GTPases Activate Formins", "R-SSC-5675221:r:Negative regulation of MAPK pathway", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-69231:r:Cyclin D associated events in G1", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-1295596:r:Spry regulation of FGF signaling", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-432142:r:Platelet sensitization by LDL", "R-SCE-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-389356:r:Co-stimulation by CD28", "R-MMU-9833482:r:PKR-mediated signaling", "R-HSA-5358747:r:CTNNB1 S33 mutants aren't phosphorylated", "R-RNO-196299:r:Beta-catenin phosphorylation cascade", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-DME-5673000:r:RAF activation", "R-DME-209413:r:Assembly of the 'destruction complex'", "R-HSA-5358749:r:CTNNB1 S37 mutants aren't phosphorylated", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-389513:r:Co-inhibition by CTLA4", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5467340:r:AXIN missense mutants destabilize the destruction complex", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-SPO-9770562:r:mRNA Polyadenylation", "R-SPO-389513:r:Co-inhibition by CTLA4", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-389513:r:Co-inhibition by CTLA4", "R-HSA-2465910:r:MASTL Facilitates Mitotic Progression", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-SSC-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-SPO-202670:r:ERKs are inactivated", "R-RNO-432142:r:Platelet sensitization by LDL", "R-MMU-69231:r:Cyclin D associated events in G1", "R-HSA-5358751:r:CTNNB1 S45 mutants aren't phosphorylated", "R-SSC-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-SPO-198753:r:ERK/MAPK targets", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DDI-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-5467348:r:Truncations of AMER1 destabilize the destruction complex", "R-SSC-68877:r:Mitotic Prometaphase", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-DME-209214:r:Phosphorylation of SMO", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-180024:r:DARPP-32 events", "R-HSA-5339716:r:Signaling by GSK3beta mutants", "R-DDI-389513:r:Co-inhibition by CTLA4", "R-SPO-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-180024:r:DARPP-32 events", "R-SCE-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-DME-209190:r:Phosphorylation of CI", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-5675221:r:Negative regulation of MAPK pathway", "R-DME-196299:r:Beta-catenin phosphorylation cascade", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-RNO-389356:r:Co-stimulation by CD28", "R-DDI-202670:r:ERKs are inactivated", "R-DME-209440:r:Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-SSC-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-198753:r:ERK/MAPK targets", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-SCE-198753:r:ERK/MAPK targets", "R-HSA-5675221:r:Negative regulation of MAPK pathway"], "type": "Domain"}, "IPR054574": {"description": "Cgl0159-like domain", "go_ids": [], "go_terms": [], "name": "Cgl0159_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054575": {"description": "Glyoxalase At5g48480-like, C-terminal", "go_ids": [], "go_terms": [], "name": "At5g48480-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054576": {"description": "Glyoxalase At5g48480-like, N-terminal", "go_ids": [], "go_terms": [], "name": "At5g48480-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054577": {"description": "OBP47-like domain", "go_ids": [], "go_terms": [], "name": "OBP47-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054578": {"description": "SpoU L30e-like, N-terminal", "go_ids": [], "go_terms": [], "name": "SpoU_sub_bind-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054579": {"description": "4-O-methyl-glucuronoyl methylesterase-like domain", "go_ids": [], "go_terms": [], "name": "GCE-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054580": {"description": "Nucleoid occlusion factor SlmA-like, C-terminal", "go_ids": [], "go_terms": [], "name": "SlmA-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054581": {"description": "Encapsulated ferritin-like", "go_ids": [], "go_terms": [], "name": "EncFtn-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054582": {"description": "Dimethylamine monooxygenase subunit DmmA-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DmmA-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054583": {"description": "Aldos-2-ulose dehydratase, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_AUDH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054584": {"description": "Envelope glycoprotein GP2-like, HR1-HR2", "go_ids": [], "go_terms": [], "name": "Ebola-like_HR1-HR2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054585": {"description": "External alternative NADH-ubiquinone oxidoreductase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NDH2-like_C", "pathway_ids": ["PWY-7279", "PWY-7269", "PWY-7998"], "pathways": ["PWY-7279:t:aerobic respiration II (cytochrome c) (yeast)", "PWY-7269:t:mitochondrial NADPH production (yeast)", "PWY-7998:t:menaquinol-4 biosynthesis II"], "type": "Domain"}, "IPR054586": {"description": "MACPF-like domain, fungal", "go_ids": [], "go_terms": [], "name": "MACPF_1_fungal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054587": {"description": "Complement C4A/B, CUB C-terminal domain", "go_ids": [], "go_terms": [], "name": "CO4A-B_CUB_C", "pathway_ids": ["R-RNO-166663", "R-MMU-977606", "R-HSA-9920588", "R-MMU-166663", "R-MMU-8957275", "R-RNO-977606", "R-RNO-174577", "R-RNO-381426", "R-HSA-977606", "R-RNO-8957275", "R-MMU-381426", "R-MMU-174577", "R-HSA-174577", "R-HSA-8957275", "R-HSA-166663", "R-HSA-381426"], "pathways": ["R-RNO-166663:r:Initial triggering of complement", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-MMU-166663:r:Initial triggering of complement", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-977606:r:Regulation of Complement cascade", "R-RNO-174577:r:Activation of C3 and C5", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-977606:r:Regulation of Complement cascade", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-174577:r:Activation of C3 and C5", "R-HSA-174577:r:Activation of C3 and C5", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-166663:r:Initial triggering of complement", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR054588": {"description": "Csa3, N-terminal", "go_ids": [], "go_terms": [], "name": "Csa3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054589": {"description": "NACHT C-terminal Helical domain 4", "go_ids": [], "go_terms": [], "name": "NCH4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054590": {"description": "Ephrin receptor 1, SAM domain-like", "go_ids": [], "go_terms": [], "name": "EPH_SAM", "pathway_ids": ["R-CEL-3928664", "R-CEL-3928663", "R-CEL-2682334", "R-CEL-3928665", "R-CEL-9013420", "R-CEL-9013424", "R-CEL-3928662", "R-CEL-9013149", "R-CEL-9013423"], "pathways": ["R-CEL-3928664:r:Ephrin signaling", "R-CEL-3928663:r:EPHA-mediated growth cone collapse", "R-CEL-2682334:r:EPH-Ephrin signaling", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-CEL-9013420:r:RHOU GTPase cycle", "R-CEL-9013424:r:RHOV GTPase cycle", "R-CEL-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-CEL-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR054591": {"description": "PL28 ulvan lyase", "go_ids": [], "go_terms": [], "name": "PL28", "pathway_ids": ["PWY-7246", "PWY-7647"], "pathways": ["PWY-7246:t:pectin degradation I", "PWY-7647:t:ulvan degradation"], "type": "Domain"}, "IPR054592": {"description": "Inactive Receiver domain", "go_ids": [], "go_terms": [], "name": "iREC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054593": {"description": "Beta-mannosidase-like, galactose-binding domain-like", "go_ids": [], "go_terms": [], "name": "Beta-mannosidase-like_N2", "pathway_ids": ["R-HSA-6798695", "R-MMU-6798695", "R-RNO-8853383", "R-MMU-8853383", "R-HSA-8853383", "R-CEL-8853383", "R-RNO-6798695", "R-CEL-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-CEL-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR054594": {"description": "Lon protease, AAA+ ATPase lid domain", "go_ids": [], "go_terms": [], "name": "Lon_lid", "pathway_ids": ["R-BTA-9033241", "R-DDI-9837999", "R-RNO-9033241", "R-MMU-9837999", "R-CEL-9837999", "R-HSA-390471", "R-SPO-9837999", "R-SCE-9837999", "R-DME-9837999", "R-HSA-9841251", "R-HSA-9837999", "R-MMU-9033241", "R-RNO-9837999", "R-HSA-9033241"], "pathways": ["R-BTA-9033241:r:Peroxisomal protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-DME-9837999:r:Mitochondrial protein degradation", "R-HSA-9841251:r:Mitochondrial unfolded protein response (UPRmt)", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-MMU-9033241:r:Peroxisomal protein import", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR054595": {"description": "Duffy-binding-like domain, C-terminal subdomain", "go_ids": [], "go_terms": [], "name": "DBL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054596": {"description": "Mono-ADP-ribosyltransferase PARP14, WWE domain", "go_ids": [], "go_terms": [], "name": "PARP14_WWE", "pathway_ids": ["R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein"], "type": "Domain"}, "IPR054597": {"description": "N-acyl amino acid synthase FeeM, catalytic core", "go_ids": [], "go_terms": [], "name": "FeeM_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054598": {"description": "Single-stranded-DNA-specific exonuclease RecJ, C-terminal domain, thermales", "go_ids": [], "go_terms": [], "name": "RecJ_C_thermales", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054599": {"description": "Transcription factor IIIA, beta-beta-alpha zinc finger", "go_ids": [], "go_terms": [], "name": "TFIIIA_Zfn-C2H2", "pathway_ids": ["R-MMU-76061", "R-HSA-76061", "R-HSA-749476", "R-RNO-76061"], "pathways": ["R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR054600": {"description": "Transcription initiation factor IIE subunit beta, E-tether", "go_ids": [], "go_terms": [], "name": "TFA2_E-tether", "pathway_ids": ["R-SCE-73779", "R-SCE-6807505", "R-SPO-76042", "R-SCE-76042", "R-SPO-674695", "R-DDI-73779", "R-SCE-75953", "R-DDI-674695", "R-SCE-674695", "R-SPO-6807505", "R-SPO-73779", "R-DDI-73776", "R-DDI-76042", "R-DDI-75953", "R-SPO-73776", "R-SPO-75953", "R-SCE-73776", "R-DDI-6807505"], "pathways": ["R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DDI-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DDI-75953:r:RNA Polymerase II Transcription Initiation", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73776:r:RNA Polymerase II Promoter Escape", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR054601": {"description": "C2185-like, N-terminal", "go_ids": [], "go_terms": [], "name": "C2185-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054603": {"description": "Plant cysteine-rich protein domain", "go_ids": [], "go_terms": [], "name": "CR_prot_dom_plant", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054604": {"description": "Surface layer protein, bacterial Ig-like domain", "go_ids": [], "go_terms": [], "name": "SbsC_Big-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054605": {"description": "S-layer protein, spectrin-like repeat", "go_ids": [], "go_terms": [], "name": "SbsA_spectrin-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054606": {"description": "NADH:ubiquinone reductase, helical insertion domain", "go_ids": [], "go_terms": [], "name": "NDH2_hel_ins", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054607": {"description": "Listeria nuclear targeted protein A, helical domain", "go_ids": [], "go_terms": [], "name": "LntA_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054608": {"description": "Tyrosine--tRNA ligase SYY-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SYY-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054609": {"description": "Transcriptional regulatory protein PF0864-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PF0864-like_C", 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dissociate a ribosome on a non-stop mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-RNO-8876725:r:Protein methylation", "R-SCE-156842:r:Eukaryotic Translation Elongation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9613829:r:Chaperone Mediated Autophagy", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SCE-3371511:r:HSF1 activation", "R-RNO-6798695:r:Neutrophil degranulation", "R-DDI-156842:r:Eukaryotic Translation Elongation", "R-HSA-6798695:r:Neutrophil degranulation", "R-SCE-8876725:r:Protein methylation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-3371511:r:HSF1 activation", "R-HSA-8876725:r:Protein methylation", "R-MTU-936635:r:Sulfate assimilation", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SPO-72764:r:Eukaryotic Translation Termination", "R-BTA-3371511:r:HSF1 activation", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-3371511:r:HSF1 activation", "R-BTA-6798695:r:Neutrophil degranulation", "R-MMU-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-GGA-8876725:r:Protein methylation", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "type": "Domain"}, "IPR054697": {"description": "Nuclear pore complex interacting protein, N-terminal", "go_ids": [], "go_terms": [], "name": "NPIP_N", "pathway_ids": ["R-HSA-9692916"], "pathways": ["R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses"], "type": "Domain"}, "IPR054698": {"description": "Radical SAM (seleno)protein TrsS", "go_ids": [], "go_terms": [], "name": "rSAM_Se_TrsS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054699": {"description": "CUAEP/CCAEP-tail radical SAM protein", "go_ids": [], "go_terms": [], "name": "rSAM_CUAEP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054700": {"description": "Methanethiol S-methyltransferase", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "MddA", "pathway_ids": ["PWY-7793"], "pathways": ["PWY-7793:t:dimethyl sulfide biosynthesis from methionine"], "type": "Family"}, "IPR054701": {"description": "DVU0298-like", "go_ids": [], "go_terms": [], "name": "DVU0298-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054703": {"description": "Molybdopterin-dependent aldehyde oxidoreductase-related", "go_ids": [], "go_terms": [], "name": "Mop-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054704": {"description": "L-lactate dehydrogenase (quinone) large subunit LdhH-like", "go_ids": [], "go_terms": [], "name": "Quin_L_LdhH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054705": {"description": "Molybdopterin-dependent aldehyde oxidoreductase", "go_ids": [], "go_terms": [], "name": "Mop", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054706": {"description": "Methyltransferase double-selenoprotein MduS", "go_ids": [], "go_terms": [], "name": "MT_CxxU_and_UXX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054707": {"description": "2,6-dihydroxypyridine 3-monooxygenase, substrate binding domain-like", "go_ids": [], "go_terms": [], "name": "DhpH_subs-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054708": {"description": "Poly(A) RNA polymerase, mitochondrial-like, central palm domain", "go_ids": [], "go_terms": [], "name": "MTPAP-like_central", "pathway_ids": ["R-HSA-9937008", "R-SPO-9770562", "R-HSA-9820865", "R-HSA-9819196", "R-HSA-9930044", "R-DRE-9770562", "R-HSA-9770562", "R-HSA-6802952", "R-MMU-9770562", "R-HSA-429947", "R-XTR-9770562", "R-RNO-9770562"], "pathways": ["R-HSA-9937008:r:Mitochondrial mRNA modification", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-9820865:r:Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-HSA-9930044:r:Nuclear RNA decay", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-429947:r:Deadenylation of mRNA", "R-XTR-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation"], "type": "Domain"}, "IPR054709": {"description": "Cilia- and flagella-associated protein 107", "go_ids": ["GO:0030317"], "go_terms": ["GO:0030317:flagellated sperm motility:P"], "name": "CFAP107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054710": {"description": "Trichothecene 3-O-acetyltransferase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Tri101-like_N", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR054711": {"description": "eIF3a, PCI domain, TPR-like region", "go_ids": [], "go_terms": [], "name": "eIF3a_PCI_TPR-like", "pathway_ids": ["R-SPO-72702", "R-DME-156827", "R-MMU-72689", "R-CEL-72702", "R-DME-72649", "R-CEL-72695", "R-XTR-72702", "R-HSA-156827", "R-RNO-72689", "R-MMU-72649", "R-HSA-72695", "R-RNO-72695", "R-MMU-72706", "R-SPO-72689", "R-SCE-72702", "R-SCE-72695", "R-MMU-72695", "R-XTR-72695", "R-DRE-156827", "R-SCE-156827", "R-MMU-72702", "R-DME-72695", "R-RNO-156827", "R-DRE-72695", "R-SPO-72706", "R-SPO-72649", "R-DDI-72702", "R-SPO-72695", "R-DDI-72695", "R-XTR-156827", "R-DME-72689", "R-HSA-72706", "R-RNO-72702", "R-HSA-72689", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-CEL-156827", "R-RNO-72649", "R-DRE-72649", "R-SCE-72649", "R-DRE-72702", "R-DRE-72689", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-DDI-156827", "R-CEL-72689", "R-DDI-72689"], "pathways": ["R-SPO-72702:r:Ribosomal scanning and start codon recognition", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72649:r:Translation initiation complex formation", "R-CEL-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-SCE-72702:r:Ribosomal scanning and start codon recognition", "R-SCE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-DME-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SPO-72649:r:Translation initiation complex formation", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-SPO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-XTR-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-DRE-72649:r:Translation initiation complex formation", "R-SCE-72649:r:Translation initiation complex formation", "R-DRE-72702:r:Ribosomal scanning and start codon recognition", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-CEL-72649:r:Translation initiation complex formation", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Domain"}, "IPR054712": {"description": "CRISPR-associated nuclease/helicase Cas3 domain", "go_ids": [], "go_terms": [], "name": "Cas3-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054713": {"description": "GMIP/FCHO2-like, FCH domain", "go_ids": [], "go_terms": [], "name": "GMIP/FCHO2-like_FCH", "pathway_ids": ["R-HSA-6798695", "R-MMU-8856828", "R-RNO-8856825", "R-MMU-8856825", "R-HSA-8856828", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-9013149", "R-MMU-9013148", "R-RNO-9013148", "R-BTA-9013148", "R-HSA-9013149", "R-DRE-9013148", "R-HSA-8980692", "R-HSA-8856825", "R-HSA-9013148", "R-DRE-9013149", "R-BTA-8980692", "R-RNO-8856828", "R-MMU-6798695", "R-DRE-8980692", "R-MMU-9013149"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR054714": {"description": "GPR158/179, extracellular domain", "go_ids": [], "go_terms": [], "name": "GPR158_179_extracellular", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054715": {"description": "Digeranylgeranylglycerophospholipid reductase, catalytic domain", "go_ids": [], "go_terms": [], "name": "GGR_cat", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054716": {"description": "Soluble Rieske-type ferredoxin domain", "go_ids": [], "go_terms": [], "name": "Sol_Rieske_ferrdox_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054717": {"description": "Internalin J, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "InlJ_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054718": {"description": "YhfS-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YhfS-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054719": {"description": "Tubulin-like protein TubZ-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TubZ-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054720": {"description": "HpiC1 cyclase", "go_ids": [], "go_terms": [], "name": "HpiC1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054721": {"description": "GEO12453p1-like", "go_ids": [], "go_terms": [], "name": "GEO12453p1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054722": {"description": "Retrovirus-related Pol polyprotein from transposon TNT 1-94-like, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "PolX-like_BBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR054723": {"description": "Alpha-mannosidase Ams1-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Ams1-like_N", "pathway_ids": ["R-SPO-8853383", "R-RNO-8853383", "R-MMU-8853383", "R-DDI-8853383", "R-HSA-8853383", "R-SCE-8853383"], "pathways": ["R-SPO-8853383:r:Lysosomal oligosaccharide catabolism", "R-RNO-8853383:r:Lysosomal oligosaccharide catabolism", "R-MMU-8853383:r:Lysosomal oligosaccharide catabolism", "R-DDI-8853383:r:Lysosomal oligosaccharide catabolism", "R-HSA-8853383:r:Lysosomal oligosaccharide catabolism", "R-SCE-8853383:r:Lysosomal oligosaccharide catabolism"], "type": "Domain"}, "IPR054724": {"description": "DNA (cytosine-5)-methyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "DNM3A_N", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-4655427", "R-RNO-212300", "R-HSA-212300", "R-HSA-9845323", "R-RNO-3214858", "R-MMU-212300", "R-HSA-5334118", "R-HSA-3214858", "R-MMU-3214858", "R-HSA-9710421"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", 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"PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR054878": {"description": "Endonuclease VIII Nei2", "go_ids": [], "go_terms": [], "name": "Endonuc_Nei2", "pathway_ids": ["PWY-7342", "PWY-5381", "PWY-2681", "PWY-5316", "PWY-7564", "PWY-8106"], "pathways": ["PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-5381:t:NAD salvage (plants)", "PWY-2681:t:trans-zeatin biosynthesis", "PWY-5316:t:nicotine biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8106:t:queuosine biosynthesis III (queuosine salvage)"], "type": "Family"}, "IPR054879": {"description": "Rad50/Mre11 complex component", "go_ids": [], "go_terms": [], "name": "Mre11_Halo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054880": {"description": "Menaquinone reductase", "go_ids": [], "go_terms": [], "name": "MkRedMenJ", "pathway_ids": ["PWY-7993"], "pathways": ["PWY-7993:t:beta-dihydromenaquinone-9 biosynthesis"], "type": "Family"}, "IPR054881": {"description": "3-phenylpropionate/cinnamic acid dioxygenase subunit beta", "go_ids": [], "go_terms": [], "name": "3PPDioc_HcaF", "pathway_ids": ["PWY-6690"], "pathways": ["PWY-6690:t:cinnamate and 3-hydroxycinnamate degradation to 2-hydroxypentadienoate"], "type": "Family"}, "IPR054882": {"description": "Outer membrane protein Omp38", "go_ids": [], "go_terms": [], "name": "Omp38", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054883": {"description": "3-phenylpropionate/cinnamic acid dioxygenase subunit alpha", "go_ids": [], "go_terms": [], "name": "3PPDioc_HcaE", "pathway_ids": ["PWY-6690"], "pathways": ["PWY-6690:t:cinnamate and 3-hydroxycinnamate degradation to 2-hydroxypentadienoate"], "type": "Family"}, "IPR054884": {"description": "DGGGPL reductase", "go_ids": [], "go_terms": [], "name": "Dggglyphlred_Halo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054885": {"description": "(2E,6E)-farnesyl diphosphate synthase", "go_ids": [], "go_terms": [], "name": "FPP_synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054886": {"description": "UDP-glucose 6-dehydrogenase AglM", "go_ids": [], "go_terms": [], "name": "UDPGDh_AglM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054887": {"description": "Dolichyl-phosphate hexose transferase", "go_ids": [], "go_terms": [], "name": "DPhHxTase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054888": {"description": "Olefin beta-lactone synthetase", "go_ids": [], "go_terms": [], "name": "OlefBLtnSyn", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054889": {"description": "N-acyl homoserine lactonase AttM", "go_ids": [], "go_terms": [], "name": "AttM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054890": {"description": "ATP-dependent DNA ligase LigA", "go_ids": [], "go_terms": [], "name": "LigA_Halo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054891": {"description": "D-2-hydroxyacid dehydrogenase", "go_ids": [], "go_terms": [], "name": "Dhydh_Halo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054892": {"description": "Lateral flagellin LafA", "go_ids": [], "go_terms": [], "name": "lat_flg_LafA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054893": {"description": "Methenyltetrahydrofolate cyclohydrolase", "go_ids": [], "go_terms": [], "name": "MthfCyhylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054894": {"description": "Assimilatory nitrate reductase NasA", "go_ids": [], "go_terms": [], "name": "Nitr_red_NasA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054895": {"description": "Peptidoglycan-N-acetylglucosamine deacetylase BC_1960", "go_ids": [], "go_terms": [], "name": "PGN_GlcNAc_Dac_BC_1960", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054896": {"description": "Lycopene cyclase, cyanobacteria", "go_ids": [], "go_terms": [], "name": "CrtY_cyanobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054897": {"description": "N-acetylglucosamine deacetylase, Lactobacillales", "go_ids": [], "go_terms": [], "name": "GlcNAc_deacetylase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054898": {"description": "Enoyl-CoA hydratase DpgD", "go_ids": [], "go_terms": [], "name": "EnCoAhydt_DpgD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054899": {"description": "Acidic tetraheme cytochrome c3 TmcA", "go_ids": [], "go_terms": [], "name": "c3_cytochr_TmcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054900": {"description": "Sulfate respiration complex protein HmcC", "go_ids": [], "go_terms": [], "name": "sulf_resp_HmcC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054901": {"description": "2-isopropylmalate synthase LeuA2", "go_ids": [], "go_terms": [], "name": "IPMS_Lepto", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054902": {"description": "1-phosphofructokinase", "go_ids": [], "go_terms": [], "name": "pfkB_Halo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054903": {"description": "Sulfate respiration complex protein HmcE", "go_ids": [], "go_terms": [], "name": "sulf_resp_HmcE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054904": {"description": "Non-specific acid phosphatase", "go_ids": [], "go_terms": [], "name": "Acid_Phosphatase_PhoC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054905": {"description": "Succinyl-CoA:mesaconate CoA-transferase", "go_ids": [], "go_terms": [], "name": "Scnl_mescCoAtase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054906": {"description": "2,3-Digeranylgeranylglycerophospholipid reductase", "go_ids": [], "go_terms": [], "name": "DGGGPL_red", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054907": {"description": "(R)-citramalate synthase", "go_ids": [], "go_terms": [], "name": "CitmalSynth_CimA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054908": {"description": "PTS phosphocarrier protein HPr", "go_ids": [], "go_terms": [], "name": "PTS-HPr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054909": {"description": "Fructose-bisphosphate aldolase class II", "go_ids": [], "go_terms": [], "name": "Fbpase2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054910": {"description": "Olefin beta-lactone synthetase, Shewanella oneidensis", "go_ids": [], "go_terms": [], "name": "OlefBLtnSynShew", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054911": {"description": "Sulfate respiration complex protein HmcD", "go_ids": [], "go_terms": [], "name": "sulf_resp_HmcD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054912": {"description": "Multifunctional alkaline phosphatase PehA", "go_ids": [], "go_terms": [], "name": "HdlasePehA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054913": {"description": "MurNAc-alpha-1P uridylyltransferase", "go_ids": [], "go_terms": [], "name": "MurNAcPUrMurU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054914": {"description": "F(420)H(2) dehydrogenase subunit D", "go_ids": [], "go_terms": [], "name": "F420_dehyd_FpoD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054915": {"description": "Outer membrane protein OmpV", "go_ids": [], "go_terms": [], "name": "OmpV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054916": {"description": "Fatty-acid O-methyltransferase", "go_ids": [], "go_terms": [], "name": "FAmtase_mtf2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054917": {"description": "Oxalate oxidoreductase subunit alpha", "go_ids": [], "go_terms": [], "name": "OxalOxred_alpha", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054918": {"description": "UPF0167 protein CbrC", "go_ids": [], "go_terms": [], "name": "UPF0167_CbrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054919": {"description": "Mycoplasma-type histidine triad protein HinT", "go_ids": [], "go_terms": [], "name": "M_plasma_HinT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054920": {"description": "NAD(P)-dependent benzaldehyde dehydrogenase", "go_ids": [], "go_terms": [], "name": "BenzalDHMdlD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054921": {"description": "Tyrosine isonitrile synthase", "go_ids": [], "go_terms": [], "name": "TyIsonSynPvcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054922": {"description": "FPO subunit F", "go_ids": [], "go_terms": [], "name": "FPO_su_F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054923": {"description": "Decorin-binding protein A", "go_ids": [], "go_terms": [], "name": "Decorin_bind_prot_A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054924": {"description": "N(G),N(G)-dimethylarginine dimethylaminohydrolase", "go_ids": ["GO:0016403", "GO:0006525", "GO:0000052"], "go_terms": ["GO:0016403:dimethylargininase activity:F", "GO:0006525:arginine metabolic process:P", "GO:0000052:obsolete citrulline metabolic process:P"], "name": "DDAH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054925": {"description": "Glucose-binding protein GlcS", "go_ids": [], "go_terms": [], "name": "GlcS_GBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054926": {"description": "Citrate synthase family", "go_ids": [], "go_terms": [], "name": "Cit_synThplmales", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054927": {"description": "Glucose ABC transporter permease GlcU", "go_ids": [], "go_terms": [], "name": "GlcU_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054928": {"description": "Fatty-acid--CoA ligase FadD21", "go_ids": [], "go_terms": [], "name": "FAAL_FadD21", "pathway_ids": ["PWY-8319", "PWY-7007", "PWY-735", "PWY-7769", "PWY-8424", "PWY-8361", "PWY-7462", "PWY-6722", "PWY-6799", "PWY-5924", "PWY-5752", "PWY-6670", "PWY-8374", "PWY-8463", "PWY-5923", "PWY-5045", "PWY-8029", "PWY-8336", "PWY-8152", "PWY-6948", "PWY-7536", "PWY-8443", "PWY-7620", "PWY-8293", "PWY-7660", "PWY-7288", "PWY-6593", "PWY-5136", "PWY-8044", "PWY-7671", "PWY-6457", "PWY-7778", "PWY-8042", "PWY-8045", "PWY-7738", "PWY-8032", "PWY-301", "PWY-8033", "PWY-5927", "PWY-5922", "PWY-7693", "PWYG-321", "PWY-8339", "PWY-8343", "PWY-5660", "PWY-7659", "PWY-8179", "PWY-8151", "PWY-8034", "PWY-5958", "PWY-6926", "PWY-7779"], "pathways": ["PWY-8319:t:NiFe(CO)(CN)2 cofactor biosynthesis", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-8361:t:apratoxin A biosynthesis", "PWY-7462:t:3,3'-disulfanediyldipropannoate degradation", "PWY-6722:t:candicidin biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-5924:t:limonene degradation II (L-limonene)", "PWY-5752:t:piperine biosynthesis", "PWY-6670:t:citronellol degradation", "PWY-8374:t:antimycin biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5923:t:limonene degradation I (D-limonene)", "PWY-5045:t:pinosylvin metabolism", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-8336:t:valinomycin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7536:t:2-amino-3-hydroxycyclopent-2-enone biosynthesis", "PWY-8443:t:cyclosporin A biosynthesis", "PWY-7620:t:naphthalene degradation (anaerobic)", "PWY-8293:t:alazopeptin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6593:t:sulfoacetate degradation", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-6457:t:cinnamoyl-CoA biosynthesis", "PWY-7778:t:2-methylpropene degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-301:t:cyclohexane-1-carboxylate degradation (anaerobic)", "PWY-8033:t:aureothin biosynthesis", "PWY-5927:t:(4S)-carveol and (4S)-dihydrocarveol degradation", "PWY-5922:t:(4R)-carveol and (4R)-dihydrocarveol degradation", "PWY-7693:t:guadinomine B biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-8343:t:leinamycin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8034:t:spectinabilin biosynthesis", "PWY-5958:t:acridone alkaloid biosynthesis", "PWY-6926:t:pyrethrin I biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation"], "type": "Family"}, "IPR054929": {"description": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase", "go_ids": [], "go_terms": [], "name": "dPGM_arch", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054930": {"description": "GTP-dependent dephospho-CoA kinase family", "go_ids": [], "go_terms": [], "name": "deph_CoA_kin_Thcocales", "pathway_ids": ["PWY-8342"], "pathways": ["PWY-8342:t:coenzyme A biosynthesis III (archaea)"], "type": "Family"}, "IPR054931": {"description": "Lysyl aminopeptidase", "go_ids": [], "go_terms": [], "name": "lys_aminopep_Arch", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054932": {"description": "Rhamnosyl O-methyltransferase family", "go_ids": [], "go_terms": [], "name": "RhmsylMtase", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Family"}, "IPR054933": {"description": "Oxalate oxidoreductase subunit delta", "go_ids": [], "go_terms": [], "name": "OxalOxred_delta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054934": {"description": "Leucine/methionine racemase", "go_ids": [], "go_terms": [], "name": "LeuMetRace", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054935": {"description": "Polysaccharide lyase 17 family", "go_ids": [], "go_terms": [], "name": "Alg_lyase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054936": {"description": "O6-methylguanine-DNA methyltransferase", "go_ids": [], "go_terms": [], "name": "DNA_protcyst_Mta_Thcoc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054937": {"description": "CoaD family phosphopantetheine adenylyltransferase", "go_ids": [], "go_terms": [], "name": "CoaD_Thcocales", "pathway_ids": ["PWY-7851", "PWY-8342"], "pathways": ["PWY-7851:t:coenzyme A biosynthesis II (eukaryotic)", "PWY-8342:t:coenzyme A biosynthesis III (archaea)"], "type": "Family"}, "IPR054938": {"description": "Hexose phosphate transporter", "go_ids": [], "go_terms": [], "name": "Hexose_phos_transporter", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054939": {"description": "2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase", "go_ids": [], "go_terms": [], "name": "KDG_KDGal_kin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054940": {"description": "L-prolyl-[peptidyl-carrier protein] dehydrogenase", "go_ids": [], "go_terms": [], "name": "ProlPCPDhRedW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054941": {"description": "NADPH-dependent hydrogenase/sulfhydrogenase 1 subunit gamma", "go_ids": [], "go_terms": [], "name": "HydG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054942": {"description": "Tungsten-containing formylmethanofuran dehydrogenase subunit FwdC", "go_ids": [], "go_terms": [], "name": "FMH_DH_FwdC", "pathway_ids": ["PWY-5209", "PWY-7784", "PWY-8305"], "pathways": ["PWY-5209:t:methyl-coenzyme M oxidation to CO2 I", "PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)", "PWY-8305:t:methoxylated aromatic compound degradation II"], "type": "Family"}, "IPR054943": {"description": "Chemoreceptor glutamine deamidase/glutamate methylesterase CheD", "go_ids": [], "go_terms": [], "name": "CheD_Thtga", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054944": {"description": "Cell wall elongation/penicillin-binding protein regulator TseB", "go_ids": [], "go_terms": [], "name": "regulator_TseB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054945": {"description": "NADPH-dependent hydrogenase/sulfhydrogenase 1 subunit alpha", "go_ids": [], "go_terms": [], "name": "sulfhyd_HydA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054946": {"description": "Pantoate kinase Mhun_0831", "go_ids": [], "go_terms": [], "name": "Mhun_0831", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054947": {"description": "Glucose import system permease protein GlcT", "go_ids": [], "go_terms": [], "name": "GlcT_permease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054948": {"description": "alpha-IPM synthase", "go_ids": [], "go_terms": [], "name": "IPMS", "pathway_ids": ["PWY-6871"], "pathways": ["PWY-6871:t:3-methylbutanol biosynthesis (engineered)"], "type": "Family"}, "IPR054949": {"description": "HTH-type transcriptional regulator CatM", "go_ids": [], "go_terms": [], "name": "HTH_CatM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054950": {"description": "Methane monooxygenase component C", "go_ids": [], "go_terms": [], "name": "MethMoxCompC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054951": {"description": "Cell division protein CdvC", "go_ids": [], "go_terms": [], "name": "cell_div_CdvC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054952": {"description": "Oxalate oxidoreductase subunit beta", "go_ids": [], "go_terms": [], "name": "OxalOxred_beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054954": {"description": "Carbonic anhydrase, gamma-class", "go_ids": [], "go_terms": [], "name": "carb_anhyd", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054955": {"description": "Methane monooxygenase regulatory protein B", "go_ids": [], "go_terms": [], "name": "MethMoxRegMmoB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054956": {"description": "Methane monooxygenase component A beta chain", "go_ids": [], "go_terms": [], "name": "MethMoxA_beta", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054957": {"description": "Phospho-furanose lactonase", "go_ids": [], "go_terms": [], "name": "PhFuoseLconase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054958": {"description": "NurA family nuclease", "go_ids": [], "go_terms": [], "name": "NurA_nuclease", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054959": {"description": "Sarcosine reductase complex component B subunit beta", "go_ids": [], "go_terms": [], "name": "Sarcosine_GrdF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR054960": {"description": "Homoisocitrate dehydrogenase", 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"R-DDI-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-BTA-390247:r:Beta-oxidation of very long chain fatty acids", "R-CEL-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-DDI-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR055061": {"description": "Cmr1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cmr1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055062": {"description": "PsV, capsid protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PsV_CP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055063": {"description": "Small ribosomal subunit protein mS39, PPR", "go_ids": [], "go_terms": [], "name": "Rib_mS39_PPR", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-DME-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-DME-5389840", "R-HSA-5389840", "R-DRE-5389840", "R-BTA-9937383", "R-MMU-5389840", "R-DME-9937383", "R-DRE-5419276"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-DME-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DME-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DME-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Repeat"}, "IPR055064": {"description": "BRISC complex subunit FAM175B, helical domain", "go_ids": [], "go_terms": [], "name": "BRISC_FAM175B_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055065": {"description": "MCM10, OB-fold", "go_ids": [], "go_terms": [], "name": "OB_MCM10", "pathway_ids": ["R-DME-68962", "R-SPO-176187", "R-DRE-68962", "R-MMU-68962", "R-MMU-176187", "R-HSA-68962", "R-SPO-68962", "R-HSA-176187", "R-SCE-176187", "R-SCE-68962", "R-DME-176187"], "pathways": ["R-DME-68962:r:Activation of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-DRE-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR055066": {"description": "4'-phosphopantetheinyl transferase, N-terminal", "go_ids": [], "go_terms": [], "name": "AASDHPPT_N", "pathway_ids": ["PWY-6012", "PWY-6289", "R-MMU-199220", "R-RNO-199220", "R-HSA-199220"], "pathways": ["PWY-6012:t:acyl carrier protein metabolism", "PWY-6289:t:petrobactin biosynthesis", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism"], "type": "Domain"}, "IPR055067": {"description": "Alpha-amylase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "AmyB-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055068": {"description": "Coat protein, P (projecting) domain", "go_ids": [], "go_terms": [], "name": "Coat_P", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055069": {"description": "Flagellar hook protein FlgE, third domain", "go_ids": [], "go_terms": [], "name": "FlgE_third", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055070": {"description": "Epidermin leader peptide-processing serine protease EpiP, N-terminal propeptide", "go_ids": [], "go_terms": [], "name": "EpiP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055071": {"description": "PHLPP-like, RA domain", "go_ids": [], "go_terms": [], "name": "RA_PHLPP-like", "pathway_ids": ["R-SPO-9013106", "R-SPO-8980692", "R-SPO-9652282", "R-HSA-199418", "R-SPO-5223345", "R-SPO-199418", "R-SPO-983168", "R-MMU-199418", "R-SPO-6803207", "R-CEL-6803207", "R-RNO-199418"], "pathways": ["R-SPO-9013106:r:RHOC GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-SPO-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-HSA-199418:r:Negative regulation of the PI3K/AKT network", "R-SPO-5223345:r:Miscellaneous transport and binding events", "R-SPO-199418:r:Negative regulation of the PI3K/AKT network", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-CEL-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-RNO-199418:r:Negative regulation of the PI3K/AKT network"], "type": "Domain"}, "IPR055072": {"description": "Ferlin, dsRNA-binding domain-like domain", "go_ids": [], "go_terms": [], "name": "Ferlin_DSRM", "pathway_ids": ["R-HSA-9662360", "R-HSA-9609523", "R-HSA-445355"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9609523:r:Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-445355:r:Smooth Muscle Contraction"], "type": "Domain"}, "IPR055073": {"description": "NOMO-like, ninth beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "NOMO1-like_9th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055075": {"description": "NOMO-like, N-terminal beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "NOMO-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055076": {"description": "Exo-oligoalginate lyase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Alg17C_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055077": {"description": "BRCA2, TR2 domain", "go_ids": [], "go_terms": [], "name": "BRCA2_TR2", "pathway_ids": ["R-HSA-5685942", "R-HSA-5693616", "R-RNO-5693579", "R-HSA-9704646", "R-RNO-5685939", "R-HSA-9709603", "R-MMU-5693616", "R-MMU-5685942", "R-HSA-5685939", "R-HSA-9709275", "R-RNO-5685942", "R-HSA-9709570", "R-HSA-9704331", "R-RNO-5693568", "R-HSA-912446", "R-HSA-9763198", "R-MMU-5685939", "R-MMU-5693568", "R-RNO-5693616", "R-MMU-5693579", "R-HSA-5693554", "R-HSA-5693579", "R-HSA-5693568", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-RNO-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-RNO-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-HSA-9709275:r:Impaired BRCA2 translocation to the nucleus", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-RNO-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-912446:r:Meiotic recombination", "R-HSA-9763198:r:Impaired BRCA2 binding to SEM1 (DSS1)", "R-MMU-5685939:r:HDR through MMEJ (alt-NHEJ)", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-RNO-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR055079": {"description": "POP1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "POP1_C", "pathway_ids": ["R-HSA-6784531"], "pathways": ["R-HSA-6784531:r:tRNA processing in the nucleus"], "type": "Domain"}, "IPR055080": {"description": "Gal80p-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gal80p-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055081": {"description": "NLP1-9, GAF domain", "go_ids": [], "go_terms": [], "name": "NLP1-9_GAF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055082": {"description": "Induced by infection", "go_ids": [], "go_terms": [], "name": "IBIN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055083": {"description": "Male-specific sperm protein Mst87F", "go_ids": [], "go_terms": [], "name": "Mst87F", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055084": {"description": "Peptide tarsal-less 1A/2A", "go_ids": [], "go_terms": [], "name": "Tal-1A_2A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055085": {"description": "Major capsid protein, jelly-roll", "go_ids": [], "go_terms": [], "name": "Major_capsid_jelly-roll", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055086": {"description": "Wheel complex protein P41, central domain", "go_ids": [], "go_terms": [], "name": "MG491_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055087": {"description": "Gliding motility protein GldL-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GldL-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055088": {"description": "Fibulin, C-terminal Ig-like domain", "go_ids": [], "go_terms": [], "name": "Fibulin_C", "pathway_ids": ["R-HSA-2129379", "R-HSA-1566948", "R-MMU-1566948", "R-RNO-2129379", "R-MMU-2129379", "R-RNO-1566948"], "pathways": ["R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-1566948:r:Elastic fibre formation", "R-MMU-1566948:r:Elastic fibre formation", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-MMU-2129379:r:Molecules associated with elastic fibres", "R-RNO-1566948:r:Elastic fibre formation"], "type": "Domain"}, "IPR055089": {"description": "COP9 signalosome complex subunit 3, N-terminal helical repeats", "go_ids": [], "go_terms": [], "name": "COP9_N", "pathway_ids": ["R-RNO-6781823", "R-BTA-8951664", "R-MMU-8856825", "R-DME-6781823", "R-HSA-8951664", "R-DME-8951664", "R-DRE-8951664", "R-GGA-8951664", "R-XTR-5696394", "R-DME-5696394", "R-DDI-8951664", "R-HSA-6781823", "R-MMU-8951664", "R-DDI-8856825", "R-BTA-6781823", "R-MMU-6781823", "R-GGA-6781823", "R-MMU-5696394", "R-CEL-5696394", "R-DRE-6781823", "R-DRE-8856825", "R-DME-8856825", "R-RNO-8856825", "R-GGA-8856825", "R-BTA-5696394", "R-DDI-6781823", "R-GGA-5696394", "R-XTR-8951664", "R-DRE-5696394", "R-RNO-5696394", "R-CEL-6781823", "R-BTA-8856825", "R-DDI-5696394", "R-HSA-8856825", "R-RNO-8951664", "R-HSA-5696394", "R-XTR-6781823", "R-CEL-8856825", "R-CEL-8951664"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-8951664:r:Neddylation", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-8951664:r:Neddylation", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-GGA-8951664:r:Neddylation", "R-XTR-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8951664:r:Neddylation", "R-DDI-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-DRE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-GGA-5696394:r:DNA Damage Recognition in GG-NER", "R-XTR-8951664:r:Neddylation", "R-DRE-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8951664:r:Neddylation", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-XTR-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR055090": {"description": "Nucleoporin NUP120, helical domain, saccharomycetes", "go_ids": [], "go_terms": [], "name": "NUP120_helical_saccharomycetes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055091": {"description": "Carrier-protein-independent halogenase WelO5-like", "go_ids": [], "go_terms": [], "name": "WelO5-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055092": {"description": "Alpha-galactosidase, N-terminal", "go_ids": [], "go_terms": [], "name": "GalA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055093": {"description": "EPS8, spectrin-like domain", "go_ids": [], "go_terms": [], "name": "EPS8_2nd", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR055094": {"description": "NUP210, Ig-like domain 15", "go_ids": [], "go_terms": [], "name": "NUP210_Ig15", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-RNO-3301854", "R-MMU-4570464", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230", "R-MMU-4085377", "R-MMU-4551638", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-HSA-4570464", "R-RNO-159236", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", 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"R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230", "R-MMU-4085377", "R-MMU-4551638", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-DME-4615885", "R-HSA-4570464", "R-RNO-159236", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-DME-4551638", "R-MMU-3301854", "R-DME-159227", "R-HSA-4085377", "R-HSA-168325", "R-MMU-170822", "R-RNO-159227", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-DME-159230", "R-RNO-4551638", "R-HSA-3232142", "R-HSA-3301854", "R-DME-3301854", "R-RNO-4085377", "R-MMU-159227", "R-RNO-170822", "R-RNO-4570464", "R-RNO-159231", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA 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"R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-191859:r:snRNP Assembly", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Domain"}, "IPR055100": {"description": "LYC1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GNAT_LYC1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055101": {"description": "Abortive infection phage resistance protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AIPR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055102": {"description": "PDXDC1-like, third domain", "go_ids": [], "go_terms": [], "name": "PDXDC1-like_3rd", "pathway_ids": ["PWY-5870", "PWY-6309", "PWY-5871", "PWY-7007", "PWY-6322", "PWY-6055", "PWY-8037", "PWY-7769", "PWY-7557", "PWY-6262", "PWY-6627", "PWY-8376", "PWY-5163", "PWY-6340", "PWY-5956", "PWY-5873", "PWY-7154", "PWY-7620", "PWY-3542", "PWY-6633", "PWY-7230", "PWY-6959", "PWY-7931", "PWY-7352", "PWY-5113", "PWY-7372", "PWY-5872", "PWY-7782", "PWY-7690", "PWY-8158", "PWY-5826", "PWY-7419", "PWY-6935", "PWY-8166", "PWY-7742", "PWY-3385", "PWY-7480", "PWY-7741", "PWY-8387", "PWY-8085", "PWY-5706", "PWY-8358"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6055:t:dimethylsulfoniopropanoate biosynthesis II (Spartina)", "PWY-8037:t:saliniketal A biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8376:t:benzene degradation III (anaerobic)", "PWY-5163:t:p-cumate degradation to 2-hydroxypentadienoate", "PWY-6340:t:5,5'-dehydrodivanillate degradation", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-7154:t:ergosterol biosynthesis II", "PWY-7620:t:naphthalene degradation (anaerobic)", "PWY-3542:t:choline biosynthesis II", "PWY-6633:t:caffeine degradation V (bacteria, via trimethylurate)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-6959:t:L-ascorbate degradation V", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-5113:t:UDP-D-apiose biosynthesis (from UDP-D-glucuronate)", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7690:t:holomycin biosynthesis", "PWY-8158:t:ibotenate and muscimol biosynthesis", "PWY-5826:t:hypoglycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6935:t:seleno-amino acid detoxification and volatilization II", "PWY-8166:t:emodin biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-3385:t:choline biosynthesis I", "PWY-7480:t:2,3-dihydroxybenzoate degradation", "PWY-7741:t:phthiocerol biosynthesis", "PWY-8387:t:microcin C biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-5706:t:alliin metabolism", "PWY-8358:t:curacin A biosynthesis"], "type": "Domain"}, "IPR055103": {"description": "PDXDC1/PDXD2, second domain", "go_ids": [], "go_terms": [], "name": "PDXDC1-like_2nd", "pathway_ids": ["PWY-5870", "PWY-6309", "PWY-5871", "PWY-7007", "PWY-6322", "PWY-6055", "PWY-8037", "PWY-7769", "PWY-7557", "PWY-6262", "PWY-6627", "PWY-8376", "PWY-5163", "PWY-6340", "PWY-5956", "PWY-5873", "PWY-7154", "PWY-7620", "PWY-3542", "PWY-6633", "PWY-7230", "PWY-6959", "PWY-7931", "PWY-7352", "PWY-5113", "PWY-7372", "PWY-5872", "PWY-7782", "PWY-7690", "PWY-8158", "PWY-5826", "PWY-7419", "PWY-6935", "PWY-8166", "PWY-7742", "PWY-3385", "PWY-7480", "PWY-7741", "PWY-8387", "PWY-8085", "PWY-5706", "PWY-8358"], "pathways": ["PWY-5870:t:ubiquinol-8 biosynthesis (late decarboxylation)", "PWY-6309:t:L-tryptophan degradation XI (mammalian, via kynurenine)", "PWY-5871:t:ubiquinol-9 biosynthesis (late decarboxylation)", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6055:t:dimethylsulfoniopropanoate biosynthesis II (Spartina)", "PWY-8037:t:saliniketal A biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-6262:t:demethylmenaquinol-8 biosynthesis II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-8376:t:benzene degradation III (anaerobic)", "PWY-5163:t:p-cumate degradation to 2-hydroxypentadienoate", "PWY-6340:t:5,5'-dehydrodivanillate degradation", "PWY-5956:t:sterigmatocystin biosynthesis", "PWY-5873:t:ubiquinol-7 biosynthesis (late decarboxylation)", "PWY-7154:t:ergosterol biosynthesis II", "PWY-7620:t:naphthalene degradation (anaerobic)", "PWY-3542:t:choline biosynthesis II", "PWY-6633:t:caffeine degradation V (bacteria, via trimethylurate)", "PWY-7230:t:ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)", "PWY-6959:t:L-ascorbate degradation V", "PWY-7931:t:brominated pyrroles biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-5113:t:UDP-D-apiose biosynthesis (from UDP-D-glucuronate)", "PWY-7372:t:demethylmenaquinol-6 biosynthesis II", "PWY-5872:t:ubiquinol-10 biosynthesis (late decarboxylation)", "PWY-7782:t:plasmalogen biosynthesis I (aerobic)", "PWY-7690:t:holomycin biosynthesis", "PWY-8158:t:ibotenate and muscimol biosynthesis", "PWY-5826:t:hypoglycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6935:t:seleno-amino acid detoxification and volatilization II", "PWY-8166:t:emodin biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-3385:t:choline biosynthesis I", "PWY-7480:t:2,3-dihydroxybenzoate degradation", "PWY-7741:t:phthiocerol biosynthesis", "PWY-8387:t:microcin C biosynthesis", "PWY-8085:t:picolinate degradation", "PWY-5706:t:alliin metabolism", "PWY-8358:t:curacin A biosynthesis"], "type": "Domain"}, "IPR055104": {"description": "CCR4-NOT transcription complex subunit 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CNOT1_1st", "pathway_ids": ["R-XTR-429947", "R-MMU-6804115", "R-HSA-6804115", "R-XTR-6804115", "R-DRE-6804115", "R-HSA-429947", "R-MMU-429947", "R-HSA-9820841"], "pathways": ["R-XTR-429947:r:Deadenylation of mRNA", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR055105": {"description": "FKRP, stem domain", "go_ids": [], "go_terms": [], "name": "FKRP_N", "pathway_ids": ["R-HSA-9939291", "R-MMU-9939291"], "pathways": ["R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1"], "type": "Domain"}, "IPR055106": {"description": "ELFN1/ELFN2, fibronectin type-III domain", "go_ids": [], "go_terms": [], "name": "ELFN_Fn3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055107": {"description": "Mediator of RNA polymerase II transcription subunit 14, RM8", "go_ids": [], "go_terms": [], "name": "Med14_RM8", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR055108": {"description": "Syntrophin, C-terminal PH domain", "go_ids": [], "go_terms": [], "name": "Syntrophin_4th", "pathway_ids": ["R-HSA-9913351", "R-CEL-9913351", "R-MMU-9913351", "R-BTA-9913351"], "pathways": ["R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-BTA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Domain"}, "IPR055109": {"description": "SMCHD1, ribosomal S5 domain 2-like domain", "go_ids": [], "go_terms": [], "name": "SMCHD1_S5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055110": {"description": "Reversion-inducing cysteine-rich with Kazal motifs, N-terminal", "go_ids": [], "go_terms": [], "name": "RECK-like_N", "pathway_ids": ["R-MMU-163125", "R-GGA-163125", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Domain"}, "IPR055111": {"description": "RNF34/RFFL, HeH domain", "go_ids": [], "go_terms": [], "name": "RNF34_RFFL_HeH", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-RNO-6804757", "R-HSA-6804757", "R-MMU-6804757", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168", "R-BTA-6804757"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-6804757:r:Regulation of TP53 Degradation"], "type": "Domain"}, "IPR055112": {"description": "Cmr7b-like, BtrG-like domain", "go_ids": [], "go_terms": [], "name": "Cmr7b-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055113": {"description": "Mediator of RNA polymerase II transcription subunit 14, RM2", "go_ids": [], "go_terms": [], "name": "Med14_RM2", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR055114": {"description": "Mediator of RNA polymerase II transcription subunit 14, RM6", "go_ids": [], "go_terms": [], "name": "Med14_RM6", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR055116": {"description": "DBF4, BRCT domain", "go_ids": [], "go_terms": [], "name": "DBF4_BRCT", "pathway_ids": ["R-SCE-176187", "R-SPO-68962", "R-SCE-68962", "R-SPO-176187"], "pathways": ["R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR055117": {"description": "MINAR1, N-terminal helical domain", "go_ids": [], "go_terms": [], "name": "MINAR1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055118": {"description": "Fatty acid synthase-like, central AT domain", "go_ids": [], "go_terms": [], "name": "FAS-like_AT_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055119": {"description": "Abnormal cell migration protein 18-like, fibronectin type I domain", "go_ids": [], "go_terms": [], "name": "Mig18_Fn1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055120": {"description": "Chitin synthase chs-1/2, N-terminal putative transporter domain", "go_ids": [], "go_terms": [], "name": "Chs-1/2_IV_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055121": {"description": "Winged helix-turn-helix domain, arthropods/nematodes", "go_ids": [], "go_terms": [], "name": "HTH_69", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055122": {"description": "Mediator complex subunit MED14, N-terminal", "go_ids": [], "go_terms": [], "name": "Med14_N", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR055123": {"description": "Polyketide synthase extender module SpnB-like, Rossmann fold domain", "go_ids": [], "go_terms": [], "name": "SpnB-like_Rossmann", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055124": {"description": "ATP-dependent RNA helicase DDX60, PIN-like domain", "go_ids": [], "go_terms": [], "name": "PIN-like_DDX60", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055125": {"description": "Wiz, C-terminal zinc finger", "go_ids": [], "go_terms": [], "name": "Wiz_C_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055126": {"description": "Enhanced disease resistance 4-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "EDR4-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055127": {"description": "YEATS domain-containing protein 2, three-helical bundle domain", "go_ids": [], "go_terms": [], "name": "YEATS2_3HBD", "pathway_ids": ["R-HSA-3214847", "R-MMU-9772755", "R-HSA-9772755"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Domain"}, "IPR055128": {"description": "Carbamoyltransferase, Kae1-like domain, second subdomain", "go_ids": [], "go_terms": [], "name": "HypF_C_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055129": {"description": "YEATS domain", "go_ids": [], "go_terms": [], "name": "YEATS_dom", "pathway_ids": ["R-HSA-8866907", "R-HSA-75955", "R-HSA-9772755", "R-MMU-674695", "R-MMU-8866907", "R-HSA-3214847", "R-MMU-9772755", "R-HSA-674695", "R-MMU-75955", "R-HSA-112382", "R-MMU-112382"], "pathways": ["R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR055130": {"description": "Presequence protease, mitochondrial-type, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PreP_C", "pathway_ids": ["PWY-8119", "R-XTR-1268020", "R-DRE-1268020", "R-DME-1268020", "R-SPO-1268020", "R-HSA-1268020", "R-MMU-1268020"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-XTR-1268020:r:Mitochondrial protein import", "R-DRE-1268020:r:Mitochondrial protein import", "R-DME-1268020:r:Mitochondrial protein import", "R-SPO-1268020:r:Mitochondrial protein import", "R-HSA-1268020:r:Mitochondrial protein import", "R-MMU-1268020:r:Mitochondrial protein import"], "type": "Domain"}, "IPR055131": {"description": "Cj1289-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cj1289-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055132": {"description": "Ribonuclease J, beta-CASP domain", "go_ids": [], "go_terms": [], "name": "RNase_J_b_CASP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055133": {"description": "Alpha-L-arabinofuranosidase, N-terminal", "go_ids": [], "go_terms": [], "name": "ArafA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055134": {"description": "RECK, EGF-like 2 domain", "go_ids": [], "go_terms": [], "name": "EGF2_RECK_dom", "pathway_ids": ["R-MMU-163125", "R-GGA-163125", "R-HSA-163125"], "pathways": ["R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-GGA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins"], "type": "Domain"}, "IPR055135": {"description": "Protein arginine N-methyltransferase domain", "go_ids": [], "go_terms": [], "name": "PRMT_dom", "pathway_ids": ["R-HSA-1989781", "R-SCE-8876725", "R-HSA-8876725", "R-XTR-8936459", "R-HSA-2151201", "R-XTR-3214858", "R-XTR-9018519", "R-RNO-3214858", "R-HSA-8936459", "R-DRE-8936459", "R-CEL-8936459", "R-RNO-9009391", "R-MMU-9009391", "R-XTR-9009391", "R-DRE-400206", "R-RNO-9018519", "R-HSA-3214858", "R-HSA-1368108", "R-RNO-8936459", "R-BTA-3214858", "R-HSA-9933387", "R-DDI-9018519", "R-HSA-9707564", "R-BTA-8936459", "R-SPO-3214858", "R-MMU-400206", "R-DME-400206", "R-HSA-9018519", "R-HSA-9931509", "R-DRE-9018519", "R-MMU-8936459", "R-RNO-400206", "R-SPO-9018519", "R-DME-9018519", "R-SCE-3214858", "R-HSA-381340", "R-DME-9707564", "R-DDI-3214858", "R-RNO-9707564", "R-HSA-9707616", "R-SPO-8876725", "R-MMU-3214858", "R-DDI-8876725", "R-HSA-9694631", "R-MMU-8876725", "R-MMU-9018519", "R-SCE-9018519", "R-HSA-9009391", "R-HSA-6804114", "R-CEL-3214858", "R-CEL-9018519", "R-RNO-8876725", "R-HSA-400206", "R-DRE-9707564", "R-DRE-3214858", "R-HSA-2426168", "R-MMU-9707564"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-SCE-8876725:r:Protein methylation", "R-HSA-8876725:r:Protein methylation", "R-XTR-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-XTR-3214858:r:RMTs methylate histone arginines", "R-XTR-9018519:r:Estrogen-dependent gene expression", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-DRE-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-XTR-9009391:r:Extra-nuclear estrogen signaling", "R-DRE-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-RNO-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-DDI-9018519:r:Estrogen-dependent gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-BTA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-SPO-3214858:r:RMTs methylate histone arginines", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-DRE-9018519:r:Estrogen-dependent gene expression", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-SPO-9018519:r:Estrogen-dependent gene expression", "R-DME-9018519:r:Estrogen-dependent gene expression", "R-SCE-3214858:r:RMTs methylate histone arginines", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9707616:r:Heme signaling", "R-SPO-8876725:r:Protein methylation", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-DDI-8876725:r:Protein methylation", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-MMU-8876725:r:Protein methylation", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-SCE-9018519:r:Estrogen-dependent gene expression", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-RNO-8876725:r:Protein methylation", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-DRE-9707564:r:Cytoprotection by HMOX1", "R-DRE-3214858:r:RMTs methylate histone arginines", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1"], "type": "Domain"}, "IPR055136": {"description": "LFE_1968-like", "go_ids": [], "go_terms": [], "name": "LFE_1968-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055137": {"description": "AlkA-like, TATA-box binding protein-like domain", "go_ids": [], "go_terms": [], "name": "AlkA-like_TBP-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055138": {"description": "Neopullulanase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Neopullulanase-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055139": {"description": "Interleukin-18-binding protein-like domain", "go_ids": [], "go_terms": [], "name": "IL18BP-like_dom", "pathway_ids": ["R-HSA-9008059", "R-HSA-9012546", "R-MMU-9012546"], "pathways": ["R-HSA-9008059:r:Interleukin-37 signaling", "R-HSA-9012546:r:Interleukin-18 signaling", "R-MMU-9012546:r:Interleukin-18 signaling"], "type": "Domain"}, "IPR055140": {"description": "Thiolase, C-terminal domain 2", "go_ids": [], "go_terms": [], "name": "Thiolase_C_2", "pathway_ids": ["R-RNO-9033241", "R-MMU-389887", "R-MMU-2046106", "R-RNO-389887", "R-MMU-193368", "R-RNO-193368", "R-RNO-2046106", "R-HSA-389887", "R-HSA-193368", "R-HSA-9033500", "R-MMU-9033241", "R-HSA-2046106", "R-HSA-9033241"], "pathways": ["R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR055141": {"description": "Transcriptional adapter 2-alpha/beta-like domain", "go_ids": [], "go_terms": [], "name": "TADA2A_B-like_dom", "pathway_ids": ["R-BTA-9772755", "R-DRE-5689880", "R-HSA-3214847", "R-MMU-9772755", "R-DME-5689880", "R-HSA-9772755", "R-RNO-9772755", "R-HSA-5689880"], "pathways": ["R-BTA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR055142": {"description": "Protein zer-1 homolog-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ZER1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055143": {"description": "Membrane-bound transcription factor site-1 protease-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MBTP1_N", "pathway_ids": ["R-HSA-1655829", "R-HSA-8963889", "R-RNO-8874177", "R-RNO-381033", "R-HSA-8874211", "R-MMU-8874211", "R-MMU-8957275", "R-RNO-8874211", "R-HSA-381033", "R-RNO-1655829", "R-RNO-381426", "R-MMU-8874177", "R-RNO-8957275", "R-HSA-8874177", "R-MMU-381426", "R-HSA-8957275", "R-MMU-381033", "R-MMU-1655829", "R-HSA-381426"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-RNO-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-HSA-8874211:r:CREB3 factors activate genes", "R-MMU-8874211:r:CREB3 factors activate genes", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-8874211:r:CREB3 factors activate genes", "R-HSA-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR055144": {"description": "tRNA-intron endonuclease SEN2-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SEN2-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055145": {"description": "PSV hypothetical protein ORF131-like domain", "go_ids": [], "go_terms": [], "name": "PSV_ORF131-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055146": {"description": "Phage DNA Adenine Methylase-like domain 2", "go_ids": [], "go_terms": [], "name": "DAM-like-phage2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055147": {"description": "Phage G20C small terminase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TerS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055148": {"description": "ZW10, C-terminal helical domain", "go_ids": [], "go_terms": [], "name": "ZW10_C_2", "pathway_ids": ["R-MMU-2500257", "R-RNO-68877", "R-MMU-141444", "R-HSA-2500257", "R-HSA-2467813", "R-RNO-6811434", "R-RNO-2500257", "R-MMU-2467813", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-RNO-5663220", "R-DME-6811434", "R-HSA-6811434", "R-HSA-68877", "R-HSA-5663220", "R-RNO-9648025", "R-RNO-2467813", "R-MMU-9648025", "R-CEL-6811434", "R-MMU-5663220", "R-RNO-141444", "R-MMU-6811434"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-DME-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR055149": {"description": "Alpha-1,3-glucanase, catalytic domain, D2", "go_ids": [], "go_terms": [], "name": "Agl_cat_D2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055150": {"description": "Iron hydrogenase 1-like, iron-sulfur centre-binding domain", "go_ids": [], "go_terms": [], "name": "Fe_hydrogense_Fe-S_bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055151": {"description": "Glycoside Hydrolase Family 113", "go_ids": [], "go_terms": [], "name": "GH113", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055152": {"description": "Transketolase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Transketolase-like_C_2", "pathway_ids": ["PWY-1861", "PWY-6901", "PWY-8178", "PWY-5723"], "pathways": ["PWY-1861:t:formaldehyde assimilation II (assimilatory RuMP Cycle)", "PWY-6901:t:superpathway of glucose and xylose degradation", "PWY-8178:t:pentose phosphate pathway (non-oxidative branch) II", "PWY-5723:t:Rubisco shunt"], "type": "Domain"}, "IPR055154": {"description": "L-gulonolactone oxidase 2-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GULLO2-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055155": {"description": "Tetracyclin repressor SMU_134-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SMU_134-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055156": {"description": "Formimidoylglutamate deiminase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HutF-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055157": {"description": "Flagellar biosynthesis protein FlhF, N domain", "go_ids": [], "go_terms": [], "name": "FlhF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055158": {"description": "Response regulator protein ChxR, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ChxR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055159": {"description": "DdMyo7, FERM domain", "go_ids": [], "go_terms": [], "name": "DdMyo7_FERM", "pathway_ids": ["R-DDI-9013418", "R-DDI-9013422"], "pathways": ["R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013422:r:RHOBTB1 GTPase cycle"], "type": "Domain"}, "IPR055160": {"description": "PilE-like, C-terminal", "go_ids": [], "go_terms": [], "name": "PilE-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055161": {"description": "Vanadium-dependent haloperoxidase NapH1-like, second helical-bundle domain", "go_ids": [], "go_terms": [], "name": "NapH1-like_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055162": {"description": "RET, cysteine rich domain", "go_ids": [], "go_terms": [], "name": "RET_CRD", "pathway_ids": ["R-HSA-9830674", "R-HSA-8853659", "R-RNO-8853659", "R-HSA-9830364", "R-MMU-8853659", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-9768919", "R-HSA-5673001"], "pathways": ["R-HSA-9830674:r:Formation of the ureteric bud", "R-HSA-8853659:r:RET signaling", "R-RNO-8853659:r:RET signaling", "R-HSA-9830364:r:Formation of the nephric duct", "R-MMU-8853659:r:RET signaling", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-5673001:r:RAF/MAP kinase cascade"], "type": "Domain"}, "IPR055163": {"description": "ALK/LTK-like, glycine-rich domain", "go_ids": [], "go_terms": [], "name": "ALK/LTK-like_GRD", "pathway_ids": ["R-HSA-9717264", "R-HSA-9700645", "R-DRE-9842663", "R-CFA-9851151", "R-HSA-9717319", "R-HSA-9842663", "R-HSA-9717301", "R-HSA-9717316", "R-MMU-9842663", "R-HSA-9851151", "R-HSA-9717329", "R-MMU-201556", "R-CFA-201556", "R-HSA-9717326", "R-HSA-201556", "R-HSA-9717323", "R-MMU-9851151", "R-HSA-9725370"], "pathways": ["R-HSA-9717264:r:ASP-3026-resistant ALK mutants", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-DRE-9842663:r:Signaling by LTK", "R-CFA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9717319:r:brigatinib-resistant ALK mutants", "R-HSA-9842663:r:Signaling by LTK", "R-HSA-9717301:r:NVP-TAE684-resistant ALK mutants", "R-HSA-9717316:r:alectinib-resistant ALK mutants", "R-MMU-9842663:r:Signaling by LTK", "R-HSA-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9717329:r:lorlatinib-resistant ALK mutants", "R-MMU-201556:r:Signaling by ALK", "R-CFA-201556:r:Signaling by ALK", "R-HSA-9717326:r:crizotinib-resistant ALK mutants", "R-HSA-201556:r:Signaling by ALK", "R-HSA-9717323:r:ceritinib-resistant ALK mutants", "R-MMU-9851151:r:MDK and PTN in ALK signaling", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Domain"}, "IPR055164": {"description": "EDR1/CTR1/ARMC3-like, peptidase-like domain", "go_ids": [], "go_terms": [], "name": "EDR1/CTR1/ARMC3-like_pept-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055165": {"description": "Flagellar protein FlgA, HotDog domain-like", "go_ids": [], "go_terms": [], "name": "FlgA_HD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055166": {"description": "Transcriptional regulator SarA/SarZ/Rot-like, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "Transc_reg_Sar_Rot_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055167": {"description": "Rootletin-like, coiled-coil", "go_ids": [], "go_terms": [], "name": "Rootletin-like_CC", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR055168": {"description": "Pyruvate-ferredoxin oxidoreductase, insertion domain", "go_ids": [], "go_terms": [], "name": "Pyruv_OxRed_insertion", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055169": {"description": "Adenylosuccinate lyase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ASLyase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055170": {"description": "GFO/IDH/MocA-like oxidoreductase domain", "go_ids": [], "go_terms": [], "name": "GFO_IDH_MocA-like_dom", "pathway_ids": ["R-MMU-9013406", "R-HSA-9013406", "R-XTR-9013406"], "pathways": ["R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-XTR-9013406:r:RHOQ GTPase cycle"], "type": "Domain"}, "IPR055171": {"description": "GT-D fold-like domain", "go_ids": [], "go_terms": [], "name": "GT-D-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055172": {"description": "RsaL-like, HTH domain", "go_ids": [], "go_terms": [], "name": "HTH_RsaL-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055173": {"description": "Transcriptional repressor NrdR-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NrdR-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055174": {"description": "Pus10, THUMP domain, archaeal", "go_ids": [], "go_terms": [], "name": "Pus10_THUMP_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055175": {"description": "ACK/TNK-like, SAM domain", "go_ids": [], "go_terms": [], "name": "ACK/TNK-like_SAM", "pathway_ids": ["R-RNO-9842663", "R-HSA-9842663", "R-MMU-9842663"], "pathways": ["R-RNO-9842663:r:Signaling by LTK", "R-HSA-9842663:r:Signaling by LTK", "R-MMU-9842663:r:Signaling by LTK"], "type": "Domain"}, "IPR055176": {"description": "UBP24/USP9X/USP9Y, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "UBP24/USP9X/USP9Y_UBL", "pathway_ids": ["R-MMU-2173795", "R-HSA-9013420", "R-DME-9033241", "R-HSA-5689880", "R-HSA-977225", "R-MMU-9013424", "R-DME-2173795", "R-DME-9013424", "R-MMU-8866652", "R-MMU-9033241", "R-HSA-9013424", "R-DME-8866652", "R-MMU-5689880", "R-MMU-9013420", "R-HSA-8866652", "R-HSA-2173795", "R-HSA-9033241", "R-DME-5689880", "R-DME-9013420"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DME-9033241:r:Peroxisomal protein import", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR055177": {"description": "UPF0425 pyridoxal phosphate-dependent protein MJ0158-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "UPF0425_MJ0158-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055178": {"description": "RsdA/BaiN/AoA(So)-like, insert domain", "go_ids": [], "go_terms": [], "name": "RsdA/BaiN/AoA(So)-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055179": {"description": "Tex-like, central region", "go_ids": [], "go_terms": [], "name": "Tex-like_central_region", "pathway_ids": ["R-CEL-674695", "R-DRE-75955", "R-HSA-112382", "R-CEL-75955", "R-DME-112382", "R-DRE-674695", "R-HSA-75955", "R-CEL-112382", "R-DME-674695", "R-HSA-674695", "R-DME-75955", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695"], "pathways": ["R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events"], "type": "Domain"}, "IPR055180": {"description": "Restriction endonuclease, type I, HsdR, second RecA-like helicase domain", "go_ids": [], "go_terms": [], "name": "HsdR_RecA-like_helicase_dom_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055181": {"description": "FGAR-AT, PurM N-terminal-like domain", "go_ids": [], "go_terms": [], "name": "FGAR-AT_PurM_N-like", "pathway_ids": ["PWY-6122", "PWY-6121", "PWY-6277", "R-SPO-73817", "R-SCE-73817", "R-MMU-73817", "R-CEL-73817", "R-HSA-73817", "R-DDI-73817", "R-DME-73817"], "pathways": ["PWY-6122:t:5-aminoimidazole ribonucleotide biosynthesis II", "PWY-6121:t:5-aminoimidazole ribonucleotide biosynthesis I", "PWY-6277:t:superpathway of 5-aminoimidazole ribonucleotide biosynthesis", "R-SPO-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-SCE-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-MMU-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-CEL-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-HSA-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DDI-73817:r:Purine ribonucleoside monophosphate biosynthesis", "R-DME-73817:r:Purine ribonucleoside monophosphate biosynthesis"], "type": "Domain"}, "IPR055183": {"description": "PTEN2A/B, C2 domain", "go_ids": [], "go_terms": [], "name": "PTEN2A/B_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055184": {"description": "COMMD8, helical N-terminal domain", "go_ids": [], "go_terms": [], "name": "COMMD8_HN", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-DDI-8951664"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-DDI-8951664:r:Neddylation"], "type": "Domain"}, "IPR055185": {"description": "BIRD-IDD transcription factor, fourth C2HC zinc finger", "go_ids": [], "go_terms": [], "name": "C2CH-4th_BIRD-IDD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055186": {"description": "BIRD-IDD transcription factor, second C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "C2H2-2nd_BIRD-IDD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055187": {"description": "BIRD-IDD transcription factor, third C2HC zinc finger", "go_ids": [], "go_terms": [], "name": "C2CH-3rd_BIRD-IDD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055188": {"description": "Choice-of-anchor I domain", "go_ids": [], "go_terms": [], "name": "Choice_anch_I", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055189": {"description": "Large ribosomal subunit protein mL44, endonuclease domain", "go_ids": [], "go_terms": [], "name": "RM44_endonuclase", "pathway_ids": ["R-CEL-9937383", "R-HSA-5419276", "R-MMU-9937383", "R-HSA-5368286", "R-CEL-5389840", "R-MMU-5419276", "R-CEL-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840"], "pathways": ["R-CEL-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-CEL-5389840:r:Mitochondrial translation elongation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-CEL-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation"], "type": "Domain"}, "IPR055190": {"description": "ATP synthase A/B type, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ATP-synt_VA_C", "pathway_ids": ["PWY-7980", "R-MMU-1222556", "R-CEL-1222556", "R-HSA-2151201", "R-DDI-77387", "R-DME-1222556", "R-HSA-77387", "R-CFA-1268020", "R-MMU-9639288", "R-SPO-9639288", "R-HSA-9639288", "R-CFA-8949613", "R-RNO-983712", "R-HSA-1268020", "R-SPO-917977", "R-MMU-1268020", "R-CEL-9639288", "R-SPO-1222556", "R-RNO-917977", "R-CFA-9837999", "R-SCE-1222556", "R-SCE-917977", "R-MMU-77387", "R-BTA-1222556", "R-SCE-77387", "R-CEL-9837999", "R-MMU-163210", "R-RNO-77387", "R-HSA-8949613", "R-HSA-163210", "R-DME-983712", "R-MMU-917977", "R-SPO-77387", "R-RNO-9639288", "R-HSA-917977", "R-CEL-1268020", "R-RNO-8949613", "R-DDI-983712", "R-BTA-77387", "R-DME-1268020", "R-DDI-917977", "R-MMU-9837999", "R-SCE-9639288", "R-CEL-163210", "R-HSA-9857377", "R-RNO-1222556", "R-DME-8949613", "R-PFA-917977", "R-HSA-1222556", "R-DDI-1222556", "R-HSA-9837999", "R-RNO-163210", "R-MMU-8949613", "R-RNO-1268020", "R-DDI-9837999", "R-DDI-9639288", "R-DDI-1268020", "R-DME-917977", "R-BTA-983712", "R-DME-77387", "R-DME-9837999", "R-DME-163210", "R-CEL-8949613", "R-RNO-9837999", "R-CFA-163210", "R-CEL-77387", "R-BTA-917977", "R-HSA-983712", "R-PFA-1222556", "R-CEL-983712", "R-SPO-9837999", "R-SCE-9837999", "R-CEL-917977", "R-MMU-983712", "R-PFA-77387", "R-BTA-9639288", "R-DME-9639288"], "pathways": ["PWY-7980:t:ATP biosynthesis", "R-MMU-1222556:r:ROS and RNS production in phagocytes", "R-CEL-1222556:r:ROS and RNS production in phagocytes", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DDI-77387:r:Insulin receptor recycling", "R-DME-1222556:r:ROS and RNS production in phagocytes", "R-HSA-77387:r:Insulin receptor recycling", "R-CFA-1268020:r:Mitochondrial protein import", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-SPO-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-CFA-8949613:r:Cristae formation", "R-RNO-983712:r:Ion channel transport", "R-HSA-1268020:r:Mitochondrial protein import", "R-SPO-917977:r:Transferrin endocytosis and recycling", "R-MMU-1268020:r:Mitochondrial protein import", "R-CEL-9639288:r:Amino acids regulate mTORC1", "R-SPO-1222556:r:ROS and RNS production in phagocytes", "R-RNO-917977:r:Transferrin endocytosis and recycling", "R-CFA-9837999:r:Mitochondrial protein degradation", "R-SCE-1222556:r:ROS and RNS production in phagocytes", "R-SCE-917977:r:Transferrin endocytosis and recycling", "R-MMU-77387:r:Insulin receptor recycling", "R-BTA-1222556:r:ROS and RNS production in phagocytes", "R-SCE-77387:r:Insulin receptor recycling", "R-CEL-9837999:r:Mitochondrial protein degradation", "R-MMU-163210:r:Formation of ATP by chemiosmotic coupling", "R-RNO-77387:r:Insulin receptor recycling", "R-HSA-8949613:r:Cristae formation", "R-HSA-163210:r:Formation of ATP by chemiosmotic coupling", "R-DME-983712:r:Ion channel transport", "R-MMU-917977:r:Transferrin endocytosis and recycling", "R-SPO-77387:r:Insulin receptor recycling", "R-RNO-9639288:r:Amino acids regulate mTORC1", "R-HSA-917977:r:Transferrin endocytosis and recycling", "R-CEL-1268020:r:Mitochondrial protein import", "R-RNO-8949613:r:Cristae formation", "R-DDI-983712:r:Ion channel transport", "R-BTA-77387:r:Insulin receptor recycling", "R-DME-1268020:r:Mitochondrial protein import", "R-DDI-917977:r:Transferrin endocytosis and recycling", "R-MMU-9837999:r:Mitochondrial protein degradation", "R-SCE-9639288:r:Amino acids regulate mTORC1", "R-CEL-163210:r:Formation of ATP by chemiosmotic coupling", "R-HSA-9857377:r:Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "R-RNO-1222556:r:ROS and RNS production in phagocytes", "R-DME-8949613:r:Cristae formation", "R-PFA-917977:r:Transferrin endocytosis and recycling", "R-HSA-1222556:r:ROS and RNS production in phagocytes", "R-DDI-1222556:r:ROS and RNS production in phagocytes", "R-HSA-9837999:r:Mitochondrial protein degradation", "R-RNO-163210:r:Formation of ATP by chemiosmotic coupling", "R-MMU-8949613:r:Cristae formation", "R-RNO-1268020:r:Mitochondrial protein import", "R-DDI-9837999:r:Mitochondrial protein degradation", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-1268020:r:Mitochondrial protein import", "R-DME-917977:r:Transferrin endocytosis and recycling", "R-BTA-983712:r:Ion channel transport", "R-DME-77387:r:Insulin receptor recycling", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DME-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-8949613:r:Cristae formation", "R-RNO-9837999:r:Mitochondrial protein degradation", "R-CFA-163210:r:Formation of ATP by chemiosmotic coupling", "R-CEL-77387:r:Insulin receptor recycling", "R-BTA-917977:r:Transferrin endocytosis and recycling", "R-HSA-983712:r:Ion channel transport", "R-PFA-1222556:r:ROS and RNS production in phagocytes", "R-CEL-983712:r:Ion channel transport", "R-SPO-9837999:r:Mitochondrial protein degradation", "R-SCE-9837999:r:Mitochondrial protein degradation", "R-CEL-917977:r:Transferrin endocytosis and recycling", "R-MMU-983712:r:Ion channel transport", "R-PFA-77387:r:Insulin receptor recycling", "R-BTA-9639288:r:Amino acids regulate mTORC1", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR055191": {"description": "DNA polymerase epsilon ,catalytic subunit A, thumb domain", "go_ids": [], "go_terms": [], "name": "POL2_thumb", "pathway_ids": ["R-DDI-6782135", "R-DME-110314", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656169", "R-HSA-5696397", "R-DDI-6782210", "R-MMU-110314", "R-DDI-68952", "R-DME-68962", "R-DDI-68962", "R-HSA-68962", "R-HSA-6782210", "R-DME-68952", "R-HSA-5656169", "R-DME-6782135", "R-SCE-68952", "R-MMU-5696400", "R-SPO-5696397", "R-DME-5651801", "R-HSA-68952", "R-MMU-68962", "R-MMU-5651801", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-SCE-68962", "R-MMU-68952", "R-DME-5656169", "R-SPO-5696400", "R-SPO-68952", "R-DME-5696400", "R-SPO-6782210", "R-SPO-110314", "R-SPO-68962", "R-HSA-5696400", "R-HSA-110314", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-SCE-6782135", "R-SPO-5651801"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-68952:r:DNA replication initiation", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-68952:r:DNA replication initiation", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-68952:r:DNA replication initiation", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-MMU-68952:r:DNA replication initiation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-68952:r:DNA replication initiation", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Domain"}, "IPR055192": {"description": "Proline-rich AKT1 substrate 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PRAS_NT", "pathway_ids": ["R-HSA-166208", "R-HSA-5674400", "R-MMU-198323", "R-MMU-165159", "R-HSA-165159", "R-HSA-3371571", "R-MMU-166208", "R-MMU-3371571", "R-HSA-198323"], "pathways": ["R-HSA-166208:r:mTORC1-mediated signalling", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-MMU-198323:r:AKT phosphorylates targets in the cytosol", "R-MMU-165159:r:MTOR signalling", "R-HSA-165159:r:MTOR signalling", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-MMU-166208:r:mTORC1-mediated signalling", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol"], "type": "Domain"}, "IPR055193": {"description": "Sulfocyanin, N-terminal", "go_ids": [], "go_terms": [], "name": "SoxE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055194": {"description": "E3 ubiquitin-protein ligase UBR1-like, winged-helix domain", "go_ids": [], "go_terms": [], "name": "UBR1-like_WH", "pathway_ids": ["PWY-7511", "R-SPO-983168", "R-DME-983168", "R-SCE-983168", "R-HSA-983168", "R-CEL-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR055195": {"description": "Integrator complex subunit 7-like, C-terminal domain, plant", "go_ids": [], "go_terms": [], "name": "INTS7_C_plant", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055196": {"description": "Pyridoxamine 5'-phosphate oxidase-like", "go_ids": [], "go_terms": [], "name": "Putative_PNPOx_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055197": {"description": "Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger", "go_ids": [], "go_terms": [], "name": "PHDvar_NSD", "pathway_ids": ["R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-MMU-3214841", "R-HSA-3214841", "R-HSA-69473", "R-HSA-5693565", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR055198": {"description": "Histone-lysine N-methyltransferase NSD-like, PHD zinc finger", "go_ids": [], "go_terms": [], "name": "NSD_PHD", "pathway_ids": ["R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-MMU-3214841", "R-HSA-3214841", "R-HSA-69473", "R-HSA-5693565", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR055199": {"description": "Hda, lid domain", "go_ids": [], "go_terms": [], "name": "Hda_lid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055201": {"description": "Integration host factor-like, helix-two turn-helix domain", "go_ids": [], "go_terms": [], "name": "IHF-like_H2TH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055204": {"description": "Heterogeneous nuclear ribonucleoprotein L, RRM domain", "go_ids": [], "go_terms": [], "name": "HNRNPL_RRM", "pathway_ids": ["R-HSA-72203", "R-MMU-72203", "R-HSA-9770562", "R-RNO-72203", "R-MMU-9770562", "R-MMU-72163", "R-SSC-72163", "R-HSA-6803529", "R-RNO-72163", "R-SSC-72203", "R-HSA-72163", "R-BTA-6803529", "R-RNO-9770562", "R-BTA-9770562", "R-SSC-6803529", "R-SSC-9770562", "R-BTA-72203", "R-HSA-9918481", "R-RNO-6803529", "R-MMU-6803529", "R-BTA-72163"], "pathways": ["R-HSA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6803529:r:FGFR2 alternative splicing", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-SSC-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-BTA-6803529:r:FGFR2 alternative splicing", "R-RNO-9770562:r:mRNA Polyadenylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-SSC-6803529:r:FGFR2 alternative splicing", "R-SSC-9770562:r:mRNA Polyadenylation", "R-BTA-72203:r:Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6803529:r:FGFR2 alternative splicing", "R-MMU-6803529:r:FGFR2 alternative splicing", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR055205": {"description": "5,10-methenyltetrahydromethanopterin hydrogenase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HMD_N", "pathway_ids": ["PWY-7784"], "pathways": ["PWY-7784:t:reductive acetyl coenzyme A pathway II (autotrophic methanogens)"], "type": "Domain"}, "IPR055206": {"description": "ATP-dependent RNA helicase SUV3, DEXQ-box helicase domain", "go_ids": [], "go_terms": [], "name": "DEXQc_SUV3", "pathway_ids": ["R-HSA-9836573"], "pathways": ["R-HSA-9836573:r:Mitochondrial RNA degradation"], "type": "Domain"}, "IPR055207": {"description": "DNA-directed RNA polymerase III subunit RPC3, winged-helix domain", "go_ids": [], "go_terms": [], "name": "POLR3C_WHD", "pathway_ids": ["R-SCE-76066", "R-DDI-76066", "R-HSA-76071", "R-RNO-76071", "R-HSA-76066", "R-HSA-73980", "R-SPO-76066", "R-SPO-76061", "R-MMU-76071", "R-BTA-76071", "R-MMU-76066", "R-RNO-76066", "R-DRE-76071", "R-BTA-76066", "R-BTA-76061", "R-DRE-76066", "R-DDI-76061", "R-RNO-76061", "R-HSA-76061", "R-HSA-1834949", "R-MMU-76061", "R-HSA-73780", "R-HSA-749476", "R-DRE-76061", "R-SCE-76061"], "pathways": ["R-SCE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-RNO-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-SPO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-SPO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DRE-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-BTA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-BTA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-DRE-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-DDI-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-DRE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-SCE-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR055208": {"description": "DNA polymerase II, insertion domain", "go_ids": [], "go_terms": [], "name": "PolB_insertion", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055209": {"description": "RsiG-like domain", "go_ids": [], "go_terms": [], "name": "RsiG-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055210": {"description": "Activating protease CtpA/B, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CtpA/B_N", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR055211": {"description": "PNO1, second type I KH domain", "go_ids": [], "go_terms": [], "name": "KH_PNO1_2nd", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-BTA-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DRE-6791226", "R-SPO-6791226", "R-HSA-6790901", "R-RNO-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR055213": {"description": "IML1/DEPDC5, N-terminal double psi beta-barrel domain", "go_ids": [], "go_terms": [], "name": "IML1_double_psi_beta_barrel", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288", "R-DDI-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DDI-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR055214": {"description": "DSP-PTPase phosphatase fused to NAD+ Kinase", "go_ids": [], "go_terms": [], "name": "PTP-NADK", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055215": {"description": "Sperm-associated microtubule inner protein 5 domain", "go_ids": [], "go_terms": [], "name": "SPMIP5_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055216": {"description": "Ant venom allergen Sol i 2/4", "go_ids": [], "go_terms": [], "name": "Sol_i_2/4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055217": {"description": "EMC2, TPR-like domain", "go_ids": [], "go_terms": [], "name": "TPR_EMC2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055218": {"description": "Amylosucrase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Amylosucrase_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055219": {"description": "Septum site-determining protein MinC, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MinC_N_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055220": {"description": "Spartan-like, zinc binding domain", "go_ids": [], "go_terms": [], "name": "SPRTN_ZBD", "pathway_ids": ["PWY-8119", "R-DRE-110320", "R-CEL-110320", "R-RNO-110320", "R-HSA-110320", "R-BTA-110320", "R-XTR-110320", "R-MMU-110320"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-DRE-110320:r:Translesion Synthesis by POLH", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-BTA-110320:r:Translesion Synthesis by POLH", "R-XTR-110320:r:Translesion Synthesis by POLH", "R-MMU-110320:r:Translesion Synthesis by POLH"], "type": "Domain"}, "IPR055221": {"description": "DNA replication complex GINS protein PSF3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PSF3_N", "pathway_ids": ["R-BTA-176974", "R-SPO-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974"], "pathways": ["R-BTA-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA"], "type": "Domain"}, "IPR055222": {"description": "PRISE-like, Rossmann-fold domain", "go_ids": [], "go_terms": [], "name": "PRISE-like_Rossmann-fold", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055223": {"description": "Fe(3+) ions import ATP-binding protein FbpC, regulatory domain", "go_ids": [], "go_terms": [], "name": "FbpC_RD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055224": {"description": "MLPTv-like, winged helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "MLPTv-like_wHTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055225": {"description": "DNAJC11-like, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "DNAJC11-like_beta-barrel", "pathway_ids": ["R-HSA-8949613"], "pathways": ["R-HSA-8949613:r:Cristae formation"], "type": "Domain"}, "IPR055226": {"description": "FilE, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FilE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055227": {"description": "ATP-dependent helicase HRQ1, winged helix domain", "go_ids": [], "go_terms": [], "name": "HRQ1_WHD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055228": {"description": "Cas9, RuvC domain", "go_ids": [], "go_terms": [], "name": "Cas9_RuvC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055229": {"description": "VEGFR1-3, fifth immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "VEGFR1-3_5th", "pathway_ids": ["R-HSA-216083", "R-DRE-194306", "R-DRE-5218921", "R-MMU-4420097", "R-RNO-195399", "R-HSA-9673768", "R-HSA-194306", "R-DRE-195399", "R-HSA-4420097", "R-MMU-195399", "R-HSA-5218921", "R-RNO-5218921", "R-HSA-9013695", "R-DRE-4420097", "R-HSA-9856530", "R-HSA-195399", "R-MMU-194306", "R-MMU-5218921", "R-RNO-194306", "R-RNO-4420097"], "pathways": ["R-HSA-216083:r:Integrin cell surface interactions", "R-DRE-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DRE-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-RNO-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-9673768:r:Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "R-HSA-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-DRE-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-DRE-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-195399:r:VEGF binds to VEGFR leading to receptor dimerization", "R-MMU-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-RNO-194306:r:Neurophilin interactions with VEGF and VEGFR", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR055230": {"description": "Tiam1/2, second PH-like domain", "go_ids": [], "go_terms": [], "name": "PH_Tiam1/2", "pathway_ids": ["R-HSA-1989781", "R-DME-9013149", "R-HSA-193648", "R-DME-8980692", "R-MMU-3928665", "R-MMU-8980692", "R-DME-3928662", "R-HSA-416482", "R-MMU-9013148", "R-MMU-9013404", "R-HSA-3928662", "R-HSA-9013404", "R-HSA-9013423", "R-MMU-9013423", "R-HSA-9013149", "R-DME-9013148", "R-HSA-8980692", "R-HSA-3928665", "R-DME-193648", "R-MMU-416482", "R-DME-416482", "R-HSA-9013148", "R-MMU-3928662", "R-DME-3928665", "R-MMU-193648", "R-MMU-9013149", "R-HSA-9032845", "R-DME-9013423"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-193648:r:NRAGE signals death through JNK", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-8980692:r:RHOA GTPase cycle", "R-DME-3928662:r:EPHB-mediated forward signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-DME-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-MMU-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9032845:r:Activated NTRK2 signals through CDK5", "R-DME-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR055231": {"description": "PIK3R4-like, middle domain", "go_ids": [], "go_terms": [], "name": "PIK3R4-like_middle", "pathway_ids": ["R-SSC-5673000", "R-HSA-9833482", "R-MMU-6811558", "R-MMU-1632852", "R-SSC-69231", "R-SPO-975957", "R-MMU-68877", "R-HSA-69231", "R-SSC-4641262", "R-MMU-380320", "R-SSC-9833482", "R-HSA-5673000", "R-RNO-1632852", "R-RNO-6811558", "R-SCE-1660517", "R-SPO-5668599", "R-HSA-5467337", "R-SSC-2565942", "R-SSC-196299", "R-DDI-198753", "R-MMU-5620912", "R-SSC-1295596", "R-RNO-5673000", "R-HSA-5358752", "R-HSA-198753", "R-SSC-8854518", "R-HSA-163767", "R-HSA-202670", "R-SSC-389356", "R-DDI-113501", "R-MMU-196299", "R-MMU-380259", "R-HSA-168138", "R-SPO-6811558", "R-SSC-432142", "R-MMU-5673000", "R-HSA-141444", "R-SCE-202670", "R-MMU-380270", "R-RNO-5675221", "R-RNO-5663220", "R-RNO-180024", "R-RNO-202670", "R-HSA-9634600", "R-SCE-1632852", "R-HSA-389356", "R-RNO-6804757", "R-HSA-1295596", "R-SSC-975957", "R-MMU-4641262", "R-SCE-389513", "R-DDI-1660514", "R-MMU-69273", "R-MMU-5663220", "R-RNO-141444", "R-MMU-9860927", "R-MMU-5675221", "R-SCE-1660516", "R-HSA-2467813", "R-RNO-4641262", "R-HSA-9705671", "R-SSC-202670", "R-MMU-380284", "R-HSA-196299", "R-RNO-9860927", "R-RNO-168138", "R-HSA-68877", "R-HSA-4641262", "R-SSC-195253", "R-SSC-2995383", "R-SSC-9860927", "R-DDI-5668599", "R-MMU-202670", "R-SSC-9648025", "R-MMU-195253", "R-HSA-195253", "R-HSA-389513", "R-SSC-389513", "R-HSA-113501", "R-DDI-9833482", "R-RNO-68877", "R-DDI-1632852", "R-MMU-109704", "R-DDI-69231", "R-MMU-975957", "R-SPO-1660514", "R-MMU-6804757", "R-MMU-113501", "R-HSA-109704", "R-HSA-2995383", "R-HSA-380270", "R-DDI-5675221", "R-RNO-69273", "R-RNO-69231", "R-MMU-389513", "R-HSA-983170", "R-HSA-975957", "R-HSA-5663220", "R-SPO-1660517", "R-RNO-9648025", "R-MMU-198753", "R-MMU-168138", "R-RNO-195253", "R-RNO-9833482", "R-SSC-180024", "R-SSC-5620912", "R-HSA-5668599", "R-SSC-198753", "R-SSC-5663220", "R-SSC-5675221", "R-MMU-1660516", "R-MMU-2467813", "R-SCE-1660514", "R-HSA-69273", "R-HSA-432142", "R-HSA-380284", "R-HSA-8854518", "R-SPO-1660516", "R-MMU-1295596", "R-MMU-2565942", "R-SSC-6811558", "R-MMU-432142", "R-SCE-6811558", "R-HSA-380320", "R-MMU-389356", "R-MMU-9833482", "R-HSA-5358747", "R-RNO-196299", "R-HSA-6804757", "R-MMU-5668599", "R-MMU-1660514", "R-DDI-1660517", "R-HSA-5358749", "R-MMU-141444", "R-SSC-380259", "R-HSA-9648025", "R-HSA-1660516", "R-HSA-5467340", "R-HSA-6811558", "R-SSC-380284", "R-SPO-389513", "R-RNO-1660517", "R-RNO-113501", "R-RNO-389513", "R-HSA-2465910", "R-HSA-1632852", "R-MMU-8854518", "R-SSC-113501", "R-RNO-2467813", "R-HSA-9860927", "R-SPO-202670", "R-MMU-1660517", "R-SPO-1632852", "R-HSA-9679504", "R-RNO-432142", "R-MMU-69231", "R-HSA-5358751", "R-SSC-380270", "R-HSA-1660517", "R-SPO-198753", "R-RNO-2500257", "R-DDI-69273", "R-DDI-6811558", "R-HSA-5467348", "R-SSC-68877", "R-RNO-109704", "R-RNO-1660514", "R-RNO-5668599", "R-HSA-2565942", "R-SCE-975957", "R-RNO-1660516", "R-MMU-180024", "R-HSA-5339716", "R-DDI-389513", "R-HSA-9920951", "R-SPO-69273", "R-HSA-5620912", "R-MMU-9648025", "R-SSC-141444", "R-MMU-2995383", "R-HSA-180024", "R-SCE-69273", "R-MMU-2500257", "R-HSA-9694676", "R-SSC-69273", "R-HSA-2500257", "R-DDI-1660516", "R-HSA-1660514", "R-SSC-2467813", "R-RNO-389356", "R-DDI-202670", "R-SSC-380320", "R-SCE-5668599", "R-SSC-2500257", "R-RNO-198753", "R-HSA-380259", "R-SCE-198753", "R-HSA-5675221"], "pathways": ["R-SSC-5673000:r:RAF activation", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-1632852:r:Macroautophagy", "R-SSC-69231:r:Cyclin D associated events in G1", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-69231:r:Cyclin D associated events in G1", "R-SSC-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-SSC-9833482:r:PKR-mediated signaling", "R-HSA-5673000:r:RAF activation", "R-RNO-1632852:r:Macroautophagy", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SCE-1660517:r:Synthesis of PIPs at the late endosome membrane", "R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases", "R-HSA-5467337:r:APC truncation mutants have impaired AXIN binding", "R-SSC-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-SSC-196299:r:Beta-catenin phosphorylation cascade", "R-DDI-198753:r:ERK/MAPK targets", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-SSC-1295596:r:Spry regulation of FGF signaling", "R-RNO-5673000:r:RAF activation", "R-HSA-5358752:r:CTNNB1 T41 mutants aren't phosphorylated", "R-HSA-198753:r:ERK/MAPK targets", "R-SSC-8854518:r:AURKA Activation by TPX2", "R-HSA-163767:r:PP2A-mediated dephosphorylation of key metabolic factors", "R-HSA-202670:r:ERKs are inactivated", "R-SSC-389356:r:Co-stimulation by CD28", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-MMU-196299:r:Beta-catenin phosphorylation cascade", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-SPO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-432142:r:Platelet sensitization by LDL", "R-MMU-5673000:r:RAF activation", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SCE-202670:r:ERKs are inactivated", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5675221:r:Negative regulation of MAPK pathway", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-RNO-180024:r:DARPP-32 events", "R-RNO-202670:r:ERKs are inactivated", "R-HSA-9634600:r:Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "R-SCE-1632852:r:Macroautophagy", "R-HSA-389356:r:Co-stimulation by CD28", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-1295596:r:Spry regulation of FGF signaling", "R-SSC-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-MMU-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-SCE-389513:r:Co-inhibition by CTLA4", "R-DDI-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-MMU-5675221:r:Negative regulation of MAPK pathway", "R-SCE-1660516:r:Synthesis of PIPs at the early endosome membrane", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-4641262:r:Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SSC-202670:r:ERKs are 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"pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055248": {"description": "PSV, transcriptional regulator domain", "go_ids": [], "go_terms": [], "name": "PSV_trans_reg_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055249": {"description": "Crb2, Tudor domain, schizosaccharomyces", "go_ids": [], "go_terms": [], "name": "Crb2_Tudor_schizosaccharomyces", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055251": {"description": "SOS1/NGEF-like, PH domain", "go_ids": [], "go_terms": [], "name": "SOS1_NGEF_PH", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9607240", "R-MMU-180336", "R-RNO-9013409", "R-MMU-114604", "R-MMU-3928665", "R-HSA-2871796", "R-MMU-9013408", "R-RNO-5687128", "R-MMU-9013409", "R-MMU-210993", "R-HSA-9027284", "R-MMU-8948751", "R-DME-9013148", "R-HSA-5218920", "R-BTA-4420097", "R-MMU-5654706", "R-HSA-8853659", "R-MMU-8851805", "R-BTA-6811558", "R-CEL-9607240", "R-RNO-416476", "R-RNO-193648", "R-MMU-5673001", "R-MMU-186763", 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"R-MMU-112412", "R-HSA-5654719", "R-CEL-5654704", "R-BTA-512988", "R-BTA-1433557", "R-CEL-193648", "R-CEL-9013423", "R-HSA-1963640", "R-HSA-5655291", "R-HSA-5655332", "R-DRE-9013409", "R-HSA-5654712", "R-MMU-9028731", "R-HSA-2871809", "R-HSA-9034864", "R-MMU-354194", "R-MMU-8983432", "R-HSA-74749", "R-HSA-9842663", "R-DME-512988", "R-HSA-180336", "R-BTA-416482", "R-RNO-9013423", "R-CEL-3928665", "R-HSA-193634", "R-CEL-179812", "R-HSA-9634285", "R-HSA-3928665", "R-HSA-912526", "R-BTA-983695", "R-BTA-9013404", "R-BTA-1257604", "R-HSA-428540", "R-MMU-5654693", "R-BTA-9027284", "R-DRE-193648", "R-CEL-114604", "R-MMU-9013149", "R-MMU-74749", "R-MMU-9696273", "R-MMU-1963640", "R-HSA-5654688", "R-MMU-416476", "R-MMU-1433559", "R-CEL-210993", "R-CEL-8980692", "R-MMU-9607240", "R-MMU-9013106", "R-CEL-354194", "R-DME-114604", "R-CEL-912631", "R-RNO-9013149", "R-HSA-2179392", "R-DME-912631", "R-MMU-9013404", "R-HSA-9670439", "R-HSA-9026519", "R-CEL-416482", "R-HSA-5654693", "R-MMU-4420097", "R-HSA-3928662", "R-CEL-5673001", "R-HSA-4420097", "R-MMU-2871796", "R-BTA-389359", "R-DME-2424491", "R-BTA-2871809", "R-CEL-1433559", "R-CEL-5654700", "R-MMU-74751", "R-DME-3928665", "R-HSA-9673767", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-9013406", "R-HSA-9664565", "R-RNO-5673001", "R-HSA-5655302", "R-CEL-9013148", "R-CEL-5654693", "R-MMU-2428933", "R-MMU-9748787", "R-MMU-1433557", "R-HSA-9665686", "R-DME-8980692", "R-HSA-210993", "R-MMU-8853659", "R-RNO-3928663", "R-HSA-2029482", "R-MMU-5654700", "R-BTA-912631", "R-RNO-9696273", "R-RNO-418885", "R-HSA-5673001", "R-HSA-9013404", "R-HSA-9013149", "R-DME-2871796", "R-HSA-8980692", "R-DME-445144", "R-HSA-9703648", "R-MMU-9013406", "R-CEL-1963640", "R-BTA-114604", "R-HSA-8948751", "R-CEL-186763", "R-MMU-5654688", "R-DME-416482", "R-DRE-416482", "R-HSA-5654704", "R-DRE-9013423", "R-MMU-375165", "R-RNO-977443", "R-CEL-375165", "R-MMU-2179392", "R-HSA-167044", "R-HSA-74751", "R-HSA-977443", "R-MMU-9013148", "R-HSA-418885", "R-HSA-416476", "R-HSA-375165", "R-HSA-1250347", "R-CEL-9013149", "R-MMU-9842663", "R-DME-6811558", "R-CEL-5654706", "R-HSA-9673770", "R-DME-2871809", "R-HSA-1236382", "R-BTA-2871796", "R-DRE-9013149", "R-CEL-5654699", "R-DME-9748787", "R-RNO-9013106", "R-HSA-8851805", "R-MMU-5654719", "R-HSA-9028731", "R-HSA-193648", "R-DRE-9013408", "R-MMU-5218920", "R-HSA-5654706", "R-CEL-445144", "R-HSA-354194", "R-MMU-3928663", "R-HSA-9679191", "R-MMU-983695", "R-HSA-1433557", "R-DME-983695", "R-MMU-2029482", "R-CEL-180336", "R-HSA-186763", "R-BTA-9013408", "R-HSA-9703465", "R-DRE-9013148", "R-HSA-3928663", "R-HSA-5687128", "R-CEL-4420097", "R-MMU-2871809", "R-HSA-112412", "R-MMU-416482", "R-MMU-3928662", "R-MMU-9013026", "R-MMU-2424491", "R-HSA-9013406", "R-DRE-416476", "R-HSA-9664422", "R-DME-4420097", "R-DME-9013423", "R-CEL-5218920", "R-MMU-418885"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9607240:r:FLT3 Signaling", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-MMU-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-210993:r:Tie2 Signaling", "R-HSA-9027284:r:Erythropoietin activates RAS", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-BTA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-8853659:r:RET signaling", "R-MMU-8851805:r:MET activates RAS signaling", "R-BTA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-9607240:r:FLT3 Signaling", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-MMU-167044:r:Signalling to RAS", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-2424491:r:DAP12 signaling", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-HSA-8983432:r:Interleukin-15 signaling", "R-CEL-74751:r:Insulin receptor signalling cascade", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-5654699:r:SHC-mediated cascade:FGFR2", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-HSA-1433559:r:Regulation of KIT signaling", "R-HSA-5654700:r:FRS-mediated FGFR2 signaling", "R-HSA-9748787:r:Azathioprine ADME", "R-CEL-1433557:r:Signaling by SCF-KIT", "R-CEL-8851805:r:MET activates RAS signaling", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-193648:r:NRAGE signals death through JNK", "R-MMU-193648:r:NRAGE signals death through JNK", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-HSA-445144:r:Signal transduction by L1", "R-BTA-8980692:r:RHOA GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-977443:r:GABA receptor activation", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-MMU-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9696264:r:RND3 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-CEL-8849932:r:Synaptic adhesion-like molecules", "R-BTA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-5654699:r:SHC-mediated cascade:FGFR2", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-HSA-2428933:r:SHC-related events triggered by IGF1R", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-CEL-2179392:r:EGFR Transactivation by Gastrin", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-DME-1433557:r:Signaling by SCF-KIT", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CEL-9748787:r:Azathioprine ADME", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-CEL-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-5654704:r:SHC-mediated cascade:FGFR3", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-2730905:r:Role of LAT2/NTAL/LAB on calcium mobilization", "R-MMU-112412:r:SOS-mediated signalling", "R-HSA-5654719:r:SHC-mediated cascade:FGFR4", "R-CEL-5654704:r:SHC-mediated cascade:FGFR3", "R-BTA-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-BTA-1433557:r:Signaling by SCF-KIT", "R-CEL-193648:r:NRAGE signals death through JNK", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-HSA-5654712:r:FRS-mediated FGFR4 signaling", "R-MMU-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9034864:r:Activated NTRK3 signals through RAS", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-8983432:r:Interleukin-15 signaling", "R-HSA-74749:r:Signal attenuation", "R-HSA-9842663:r:Signaling by LTK", "R-DME-512988:r:Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-BTA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-CEL-179812:r:GRB2 events in EGFR signaling", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-BTA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-BTA-9013404:r:RAC2 GTPase cycle", "R-BTA-1257604:r:PIP3 activates AKT signaling", "R-HSA-428540:r:Activation of RAC1", "R-MMU-5654693:r:FRS-mediated FGFR1 signaling", "R-BTA-9027284:r:Erythropoietin activates RAS", "R-DRE-193648:r:NRAGE signals death through JNK", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-74749:r:Signal attenuation", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-5654688:r:SHC-mediated cascade:FGFR1", "R-MMU-416476:r:G alpha (q) signalling events", "R-MMU-1433559:r:Regulation of KIT signaling", "R-CEL-210993:r:Tie2 Signaling", "R-CEL-8980692:r:RHOA GTPase cycle", "R-MMU-9607240:r:FLT3 Signaling", "R-MMU-9013106:r:RHOC GTPase cycle", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-DME-114604:r:GPVI-mediated activation cascade", "R-CEL-912631:r:Regulation of signaling by CBL", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-DME-912631:r:Regulation of signaling by CBL", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9670439:r:Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-9026519:r:Activated NTRK2 signals through RAS", "R-CEL-416482:r:G alpha (12/13) signalling events", "R-HSA-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-5673001:r:RAF/MAP kinase cascade", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-BTA-389359:r:CD28 dependent Vav1 pathway", "R-DME-2424491:r:DAP12 signaling", "R-BTA-2871809:r:FCERI mediated Ca+2 mobilization", "R-CEL-1433559:r:Regulation of KIT signaling", "R-CEL-5654700:r:FRS-mediated FGFR2 signaling", "R-MMU-74751:r:Insulin receptor signalling cascade", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-9673767:r:Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-CEL-9013148:r:CDC42 GTPase cycle", "R-CEL-5654693:r:FRS-mediated FGFR1 signaling", "R-MMU-2428933:r:SHC-related events triggered by IGF1R", "R-MMU-9748787:r:Azathioprine ADME", "R-MMU-1433557:r:Signaling by SCF-KIT", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-210993:r:Tie2 Signaling", "R-MMU-8853659:r:RET signaling", "R-RNO-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-5654700:r:FRS-mediated FGFR2 signaling", "R-BTA-912631:r:Regulation of signaling by CBL", "R-RNO-9696273:r:RND1 GTPase cycle", "R-RNO-418885:r:DCC mediated attractive signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DME-2871796:r:FCERI mediated MAPK activation", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DME-445144:r:Signal transduction by L1", "R-HSA-9703648:r:Signaling by FLT3 ITD and TKD mutants", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-CEL-1963640:r:GRB2 events in ERBB2 signaling", "R-BTA-114604:r:GPVI-mediated activation cascade", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-CEL-186763:r:Downstream signal transduction", "R-MMU-5654688:r:SHC-mediated cascade:FGFR1", "R-DME-416482:r:G alpha (12/13) signalling events", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-5654704:r:SHC-mediated cascade:FGFR3", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-MMU-375165:r:NCAM signaling for neurite out-growth", "R-RNO-977443:r:GABA receptor activation", "R-CEL-375165:r:NCAM signaling for neurite out-growth", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-167044:r:Signalling to RAS", "R-HSA-74751:r:Insulin receptor signalling cascade", "R-HSA-977443:r:GABA receptor activation", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-375165:r:NCAM signaling for neurite out-growth", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-MMU-9842663:r:Signaling by LTK", "R-DME-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-CEL-5654706:r:FRS-mediated FGFR3 signaling", "R-HSA-9673770:r:Signaling by PDGFRA extracellular domain mutants", "R-DME-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-BTA-2871796:r:FCERI mediated MAPK activation", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-CEL-5654699:r:SHC-mediated cascade:FGFR2", "R-DME-9748787:r:Azathioprine ADME", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-8851805:r:MET activates RAS signaling", "R-MMU-5654719:r:SHC-mediated cascade:FGFR4", "R-HSA-9028731:r:Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-193648:r:NRAGE signals death through JNK", "R-DRE-9013408:r:RHOG GTPase cycle", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5654706:r:FRS-mediated FGFR3 signaling", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-1433557:r:Signaling by SCF-KIT", "R-DME-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-CEL-180336:r:SHC1 events in EGFR signaling", "R-HSA-186763:r:Downstream signal transduction", "R-BTA-9013408:r:RHOG GTPase cycle", "R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-112412:r:SOS-mediated signalling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-2424491:r:DAP12 signaling", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DRE-416476:r:G alpha (q) signalling events", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DME-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR055252": {"description": "Desulfoferrodoxin-like, N-terminal", "go_ids": [], "go_terms": [], "name": "RBO-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055253": {"description": "Argonaute, N-terminal domain, thermococcales", "go_ids": [], "go_terms": [], "name": "Ago_N_thermococcales", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055254": {"description": "pPIWI_RE three-gene island, domain Z", "go_ids": [], "go_terms": [], "name": "pPIWI_RE_Z", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055256": {"description": "KHDC4/BBP-like, KH-domain type I", "go_ids": [], "go_terms": [], "name": "KH_1_KHDC4/BBP-like", "pathway_ids": ["R-HSA-72163", "R-MMU-8849468", "R-RNO-8849468", "R-HSA-6802952", "R-MMU-72163", "R-XTR-8849468", "R-DRE-8849468", "R-HSA-8849468"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-RNO-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-XTR-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-DRE-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing", "R-HSA-8849468:r:PTK6 Regulates Proteins Involved in RNA Processing"], "type": "Domain"}, "IPR055259": {"description": "Spore protein YkvP/CgeB, glycosyl transferase-like domain", "go_ids": [], "go_terms": [], "name": "YkvP/CgeB_Glyco_trans-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055260": {"description": "Kinetochore protein Ndc80, CH domain", "go_ids": [], "go_terms": [], "name": "Ndc80_CH", "pathway_ids": ["R-MMU-2500257", "R-XTR-9648025", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-DRE-2500257", "R-MMU-2467813", "R-XTR-2467813", "R-HSA-141444", "R-XTR-5663220", "R-HSA-9648025", "R-XTR-68877", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-GGA-2500257", "R-GGA-141444", "R-XTR-141444", "R-HSA-68877", "R-GGA-9648025", "R-GGA-5663220", "R-HSA-5663220", "R-DRE-5663220", "R-GGA-2467813", "R-MMU-9648025", "R-XTR-2500257", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR055261": {"description": "Phosphatidylinositol transfer protein, N-terminal", "go_ids": [], "go_terms": [], "name": "PI_transfer_N", "pathway_ids": ["R-HSA-1483226", "R-BTA-1483196", "R-DDI-1483226", "R-MMU-1483226", "R-RNO-1483196", "R-HSA-418890", "R-HSA-8950505", "R-HSA-1483196", "R-RNO-1483226", "R-DME-1483226", "R-DDI-1483196", "R-MMU-1483196"], "pathways": ["R-HSA-1483226:r:Synthesis of PI", "R-BTA-1483196:r:PI and PC transport between ER and Golgi membranes", "R-DDI-1483226:r:Synthesis of PI", "R-MMU-1483226:r:Synthesis of PI", "R-RNO-1483196:r:PI and PC transport between ER and Golgi membranes", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-1483196:r:PI and PC transport between ER and Golgi membranes", "R-RNO-1483226:r:Synthesis of PI", "R-DME-1483226:r:Synthesis of PI", "R-DDI-1483196:r:PI and PC transport between ER and Golgi membranes", "R-MMU-1483196:r:PI and PC transport between ER and Golgi membranes"], "type": "Domain"}, "IPR055264": {"description": "BOD1/SHG1 domain", "go_ids": [], "go_terms": [], "name": "BOD1/SHG1_dom", "pathway_ids": ["R-MMU-9772755", "R-HSA-9772755"], "pathways": ["R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Domain"}, "IPR055266": {"description": "Photosystem II protein D1/D2", "go_ids": [], "go_terms": [], "name": "D1/D2", "pathway_ids": ["PWY-101"], "pathways": ["PWY-101:t:photosynthesis light reactions"], "type": "Family"}, "IPR055267": {"description": "Aerolysin-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Aerolysin-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055268": {"description": "Pyruvate carboxylase-like", "go_ids": [], "go_terms": [], "name": "PCB-like", "pathway_ids": ["PWY-6146", "PWY-6142", "PWY-8086", "R-CEL-196780", "R-MMU-70268", "R-SPO-70268", "R-HSA-196780", "R-BTA-196780", "R-MMU-70263", "R-HSA-3371599", "R-MMU-196780", "R-HSA-70268", "R-BTA-70268", "R-SPO-196780", "R-CEL-70268", "R-RNO-196780", "R-HSA-70263", "R-CEL-70263", "R-RNO-70268", "R-BTA-70263", "R-SPO-70263", "R-SCE-70263", "R-SCE-196780", "R-SCE-70268", "R-RNO-70263"], "pathways": ["PWY-6146:t:Methanobacterium thermoautotrophicum biosynthetic metabolism", "PWY-6142:t:gluconeogenesis II (Methanobacterium thermoautotrophicum)", "PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "R-CEL-196780:r:Biotin transport and metabolism", "R-MMU-70268:r:Pyruvate metabolism", "R-SPO-70268:r:Pyruvate metabolism", "R-HSA-196780:r:Biotin transport and metabolism", "R-BTA-196780:r:Biotin transport and metabolism", "R-MMU-70263:r:Gluconeogenesis", "R-HSA-3371599:r:Defective HLCS causes multiple carboxylase deficiency", "R-MMU-196780:r:Biotin transport and metabolism", "R-HSA-70268:r:Pyruvate metabolism", "R-BTA-70268:r:Pyruvate metabolism", "R-SPO-196780:r:Biotin transport and metabolism", "R-CEL-70268:r:Pyruvate metabolism", "R-RNO-196780:r:Biotin transport and metabolism", "R-HSA-70263:r:Gluconeogenesis", "R-CEL-70263:r:Gluconeogenesis", "R-RNO-70268:r:Pyruvate metabolism", "R-BTA-70263:r:Gluconeogenesis", "R-SPO-70263:r:Gluconeogenesis", "R-SCE-70263:r:Gluconeogenesis", "R-SCE-196780:r:Biotin transport and metabolism", "R-SCE-70268:r:Pyruvate metabolism", "R-RNO-70263:r:Gluconeogenesis"], "type": "Family"}, "IPR055269": {"description": "Alpha crystallin/Heat shock protein Hsp-16.1/Hsp-16.2", "go_ids": [], "go_terms": [], "name": "Alpha-crystallin/HSP_16", "pathway_ids": ["R-DME-3371571", "R-HSA-3371571", "R-RNO-3371571", "R-BTA-3371571", "R-CEL-3371571", "R-MMU-3371571", "R-SSC-3371571", "R-GGA-3371571"], "pathways": ["R-DME-3371571:r:HSF1-dependent transactivation", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-RNO-3371571:r:HSF1-dependent transactivation", "R-BTA-3371571:r:HSF1-dependent transactivation", "R-CEL-3371571:r:HSF1-dependent transactivation", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-SSC-3371571:r:HSF1-dependent transactivation", "R-GGA-3371571:r:HSF1-dependent transactivation"], "type": "Family"}, "IPR055270": {"description": "Fucosyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "Glyco_tran_10_C", "pathway_ids": ["R-DRE-5173105", "R-RNO-9037629", "R-HSA-975578", "R-DME-975578", "R-HSA-9037629", "R-RNO-5173105", "R-CFA-9037629", "R-CFA-5173105", "R-BTA-9037629", "R-DME-9037629", "R-MMU-5173105", "R-CEL-9037629", "R-MMU-9037629", "R-HSA-5173105", "R-CEL-975578"], "pathways": ["R-DRE-5173105:r:O-linked glycosylation", "R-RNO-9037629:r:Lewis blood group biosynthesis", "R-HSA-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-DME-975578:r:Reactions specific to the complex N-glycan synthesis pathway", "R-HSA-9037629:r:Lewis blood group biosynthesis", "R-RNO-5173105:r:O-linked glycosylation", "R-CFA-9037629:r:Lewis blood group biosynthesis", "R-CFA-5173105:r:O-linked glycosylation", "R-BTA-9037629:r:Lewis blood group biosynthesis", "R-DME-9037629:r:Lewis blood group biosynthesis", "R-MMU-5173105:r:O-linked glycosylation", "R-CEL-9037629:r:Lewis blood group biosynthesis", "R-MMU-9037629:r:Lewis blood group biosynthesis", "R-HSA-5173105:r:O-linked glycosylation", "R-CEL-975578:r:Reactions specific to the complex N-glycan synthesis pathway"], "type": "Domain"}, "IPR055271": {"description": "Neuron-derived neurotrophic factor, first Fn(III) domain", "go_ids": [], "go_terms": [], "name": "NDNF_Fn(III)_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055272": {"description": "POPDC1-3 domain", "go_ids": [], "go_terms": [], "name": "POPDC1-3_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055273": {"description": "CBG09102/CBG15751-like domain", "go_ids": [], "go_terms": [], "name": "CBG09102/CBG15751-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055274": {"description": "SWOLLEN 1", "go_ids": [], "go_terms": [], "name": "SWO1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055275": {"description": "Ferredoxin-NADP reductase-like", "go_ids": ["GO:0016491"], "go_terms": ["GO:0016491:oxidoreductase activity:F"], "name": "Ferredox_Rdtase", "pathway_ids": ["R-MMU-196108", "R-HSA-196108", "R-RNO-2395516", "R-DDI-2395516", "R-SCE-2395516", "R-MMU-211976", "R-RNO-211976", "R-HSA-2395516", "R-HSA-5579026", "R-MMU-2395516", "R-SPO-2395516", "R-HSA-211976", "R-RNO-196108", "R-DME-2395516"], "pathways": ["R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-RNO-2395516:r:Electron transport from NADPH to Ferredoxin", "R-DDI-2395516:r:Electron transport from NADPH to Ferredoxin", "R-SCE-2395516:r:Electron transport from NADPH to Ferredoxin", "R-MMU-211976:r:Endogenous sterols", "R-RNO-211976:r:Endogenous sterols", "R-HSA-2395516:r:Electron transport from NADPH to Ferredoxin", "R-HSA-5579026:r:Defective CYP11A1 causes AICSR", "R-MMU-2395516:r:Electron transport from NADPH to Ferredoxin", "R-SPO-2395516:r:Electron transport from NADPH to Ferredoxin", "R-HSA-211976:r:Endogenous sterols", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-DME-2395516:r:Electron transport from NADPH to Ferredoxin"], "type": "Family"}, "IPR055276": {"description": "NHL41-like", "go_ids": [], "go_terms": [], "name": "NHL41-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055277": {"description": "Fanconi anaemia group A protein, C-terminal", "go_ids": [], "go_terms": [], "name": "Fanconi_A_C", "pathway_ids": ["R-HSA-6783310", "R-HSA-9833482", "R-MMU-9833482", "R-MMU-6783310"], "pathways": ["R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR055278": {"description": "Cell division control protein 48 homolog C", "go_ids": ["GO:0016887"], "go_terms": ["GO:0016887:ATP hydrolysis activity:F"], "name": "CDC48c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055280": {"description": "Short-chain dehydrogenase TIC 32", "go_ids": [], "go_terms": [], "name": "TIC32", "pathway_ids": ["PWY-5882", "PWY-5848", "PWY-7045", "PWY-5751", "PWY-7825", "PWY-7788", "PWY-5666", "PWY-8132", "PWY-8426", "PWY-5392", "PWY-6627", "PWY-6946", "PWY-7300", "PWY-6392", "PWY-6945", "PWY-6302", "PWY-8238", "PWY-7948", "PWY-7689", "PWY-8029", "PWY-7321", "PWY-7340", "PWY-7385", "PWY-7440", "PWY-7726", "PWY-5972", "PWY-7692", "PWY-1186", "PWY-8370", "PWY-7489", "PWY-7615", "PWY-7757", "PWY-7337", "PWY-6883", "PWY-7694", "PWY-7693", "PWY-6672", "PWY-7568", "PWY-3162", "PWY-5316", "PWY-5818", "PWY-7787", "PWY-6080", "PWY-7667", "PWY-6926", "PWY-6539", "PWY-5978", "PWY-6634", "PWY-5830", "PWY-8383", "PWY-6322", "PWY-8411", "PWY-7338", "PWY-6704", "PWY-6583", "PWY-8139", "PWY-5652", "PWY-8374", "PWY-7342", "PWY-7774", "PWY-6693", "PWY-7354", "PWY-7531", "PWY-7547", "PWY-6738", "PWY-8012", "PWY-6682", "PWY-7331", "PWY-7104", "PWY-7490", "PWY-6920", "PWY-7811", "PWY-7339", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7657", "PWY-8419", "PWY-5271", "PWY-7734", "PWY-7682", "PWY-7541", "PWY-6626", "PWY-6391", "PWY-6638", "PWY-8152", "PWY-3261", "PWY-8464", "PWY-6733", "PWY-321", "PWY-6637", "PWY-7660", "PWY-6944", "PWY-7288", "PWY-6659", "PWY-7301", "PWY-8367", "PWY-6786", "PWY-6973", "PWY-2541", "PWYG-321", "PWY-5883", "PWY-6053", "PWY-7042", "PWY-7742", "PWY-7621", "PWY-8410", "PWY-5867", "PWY-8214", "PWY-7554", "PWY-8409", "PWY-7814", "PWY-7557", "PWY-8297", "PWY-7403", "PWY-7241", "PWY-6948", "PWY-7610", "PWY-8155", "PWY-6974", "PWY-2601", "PWY-7396", "PWY-7695", "PWY-7304", "PWY-8058", "PWY-8366", "PWY-7043", "PWY-7520", "PWY-6863", "PWY-6976", "PWY-3722", "PWY-7352", "PWY-6989", "PWY-6061", "PWY-8408", "PWY-7649", "PWY-8397", "PWY-7613", "PWY-5782", "PWY-741", "PWY-7333", "PWY-5101", "PWY-7775", "PWY-1121", "PWY-7606", "PWY-7741", "PWY-7779"], "pathways": ["PWY-5882:t:epoxypseudoisoeugenol-2-methylbutanoate biosynthesis", "PWY-5848:t:cinchona alkaloids biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-5751:t:phenylethanol biosynthesis", "PWY-7825:t:juglone degradation", "PWY-7788:t:erythritol degradation II", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-5392:t:reductive TCA cycle II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-6392:t:meso-butanediol biosynthesis II", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-7692:t:bikaverin biosynthesis", "PWY-1186:t:L-homomethionine biosynthesis", "PWY-8370:t:leporin B biosynthesis", "PWY-7489:t:oryzalexin A, B, and C biosynthesis", "PWY-7615:t:pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)", "PWY-7757:t:bisphenol A degradation", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7568:t:L-galactose degradation", "PWY-3162:t:L-tryptophan degradation V (side chain pathway)", "PWY-5316:t:nicotine biosynthesis", "PWY-5818:t:validamycin biosynthesis", "PWY-7787:t:L-threitol degradation", "PWY-6080:t:4-ethylphenol degradation (anaerobic)", "PWY-7667:t:apicidin biosynthesis", "PWY-6926:t:pyrethrin I biosynthesis", "PWY-6539:t:(Z)-phenylmethanethial S-oxide biosynthesis", "PWY-5978:t:kanosamine biosynthesis I", "PWY-6634:t:3-sulfopropanediol degradation I", "PWY-5830:t:CDP-ascarylose biosynthesis", "PWY-8383:t:myxochelin A and B biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-7338:t:10-trans-heptadecenoyl-CoA 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"PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7657:t:dTDP-beta-L-digitoxose biosynthesis", "PWY-8419:t:L-canavanine degradation II", "PWY-5271:t:abscisic acid degradation to phaseic acid", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7682:t:arabidopyrone biosynthesis", "PWY-7541:t:1,2-propanediol biosynthesis from lactate (engineered)", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6391:t:meso-butanediol biosynthesis I", "PWY-6638:t:sulfolactate degradation III", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-3261:t:UDP-beta-L-rhamnose biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-6637:t:sulfolactate degradation II", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-6053:t:dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)", "PWY-7042:t:the visual cycle (insects)", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "PWY-5867:t:t-anethole biosynthesis", "PWY-8214:t:3-sulfopropanediol degradation II", "PWY-7554:t:heme d1 biosynthesis", "PWY-8409:t:cyathin biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-8297:t:6-diazo-5-oxo-L-norleucine biosynthesis", "PWY-7403:t:tetramethylpyrazine degradation", "PWY-7241:t:myo-inositol degradation II", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-8155:t:testosterone degradation (anaerobic)", "PWY-6974:t:dTDP-beta-L-olivose biosynthesis", "PWY-2601:t:isethionate degradation", "PWY-7396:t:butanol and isobutanol biosynthesis (engineered)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7304:t:3-amino-4,7-dihydroxy-coumarin biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8366:t:septacidin biosynthesis", "PWY-7043:t:11-cis-3-hydroxyretinal biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-3722:t:glycine betaine biosynthesis II (Gram-positive bacteria)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6989:t:(S)-camphor degradation", "PWY-6061:t:bile 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"Family"}, "IPR055283": {"description": "Signaling peptide TAXIMIN 1/2", "go_ids": [], "go_terms": [], "name": "TAXIMIN_1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055284": {"description": "Galaxin-like", "go_ids": [], "go_terms": [], "name": "Galaxin-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055285": {"description": "Ankyrin repeat domain-containing protein 13, C-terminal", "go_ids": [], "go_terms": [], "name": "ANKRD13_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055286": {"description": "Ribitol-5-phosphate xylosyltransferase 1-like", "go_ids": ["GO:0035269", "GO:0120053"], "go_terms": ["GO:0035269:protein O-linked glycosylation via mannose:P", "GO:0120053:ribitol beta-1,4-xylosyltransferase activity:F"], "name": "RXYLT1-like", "pathway_ids": ["PWY-7981", "R-HSA-9939291", "R-DRE-9939291", "R-MMU-9939291"], "pathways": ["PWY-7981:t:alpha-dystroglycan glycosylation", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", 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"R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the 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"pathway_ids": ["R-HSA-390522"], "pathways": ["R-HSA-390522:r:Striated Muscle Contraction"], "type": "Family"}, "IPR055298": {"description": "AtLOH3-like", "go_ids": [], "go_terms": [], "name": "AtLOH3-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055299": {"description": "Complex I assembly factor TIMMDC1", "go_ids": ["GO:0032981"], "go_terms": ["GO:0032981:mitochondrial respiratory chain complex I assembly:P"], "name": "TIMMDC1", "pathway_ids": ["R-HSA-6799198", "R-MMU-6799198", "R-DME-6799198", "R-DRE-6799198", "R-RNO-6799198"], "pathways": ["R-HSA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-DME-6799198:r:Complex I biogenesis", "R-DRE-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis"], "type": "Family"}, "IPR055300": {"description": "Cysteine-tryptophan domain-containing zinc finger protein 3/5/7", "go_ids": [], "go_terms": [], "name": "CWZF3/5/7", "pathway_ids": [], "pathways": [], "type": "Family"}, 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"IPR055316": {"description": "Radial spoke head protein 9 homolog", "go_ids": ["GO:0035082"], "go_terms": ["GO:0035082:axoneme assembly:P"], "name": "RSP9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055317": {"description": "CLAVATA3/ESR (CLE)-related protein 14-like", "go_ids": [], "go_terms": [], "name": "CLE14-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055319": {"description": "At5g58720-like", "go_ids": [], "go_terms": [], "name": "At5g58720-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055320": {"description": "Centrosomal protein of 72 kDa-like", "go_ids": [], "go_terms": [], "name": "CEP72-like", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-MMU-380270", "R-DRE-380320", "R-HSA-380284", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-HSA-380270", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic 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"pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055330": {"description": "Preprotein translocase subunit SECE1-like", "go_ids": [], "go_terms": [], "name": "SECE1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055331": {"description": "FMR1 neighbor protein-like", "go_ids": [], "go_terms": [], "name": "FMR1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055334": {"description": "Peroxisomal biogenesis factor 8-like", "go_ids": [], "go_terms": [], "name": "PEX8-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055335": {"description": "UBA domain-containing protein 6/RUP1", "go_ids": [], "go_terms": [], "name": "Ucp6/RUP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055336": {"description": "F-box protein At4g00755-like", "go_ids": [], "go_terms": [], "name": "At4g00755-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055338": {"description": "YqfX-like", "go_ids": [], "go_terms": [], "name": 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["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR055344": {"description": "Protein-export membrane protein SecD/SecF, C-terminal, bacterial", "go_ids": [], "go_terms": [], "name": "SecD_SecF_C_bact", "pathway_ids": ["R-HSA-1222387"], "pathways": ["R-HSA-1222387:r:Tolerance of reactive oxygen produced by macrophages"], "type": "Domain"}, "IPR055345": {"description": "Large ribosomal subunit protein eL24-like, archaea", "go_ids": ["GO:0003735"], "go_terms": ["GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_eL24-like_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055346": {"description": "SUF system FeS cluster assembly, SufBD", "go_ids": ["GO:0016226"], "go_terms": ["GO:0016226:iron-sulfur cluster assembly:P"], "name": "Fe-S_cluster_assembly_SufBD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR055347": {"description": "U3 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"R-MMU-5683826", "R-MMU-446203", "R-MMU-1502540", "R-MMU-2534343", "R-RNO-9839397", "R-MMU-2173789", "R-MMU-9839389", "R-HSA-446203", "R-HSA-9839394", "R-RNO-446203", "R-RNO-9839383", "R-HSA-190373", "R-HSA-9839383", "R-HSA-1502540", "R-SSC-2534343", "R-HSA-190370", "R-RNO-5683826", "R-RNO-163125", "R-HSA-163125", "R-HSA-9839397", "R-HSA-2534343", "R-HSA-5683826", "R-RNO-1502540", "R-RNO-9839406"], "pathways": ["R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-MMU-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-MMU-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-201451:r:Signaling by BMP", "R-HSA-9925561:r:Developmental Lineage of Pancreatic Acinar Cells", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-BTA-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-MMU-201451:r:Signaling by BMP", "R-RNO-201451:r:Signaling by BMP", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-446203:r:Asparagine N-linked glycosylation", "R-MMU-1502540:r:Signaling by Activin", "R-MMU-2534343:r:Interaction With Cumulus Cells And The Zona Pellucida", "R-RNO-9839397:r:TGFBR3 regulates FGF2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-HSA-9839394:r:TGFBR3 expression", "R-RNO-446203:r:Asparagine N-linked glycosylation", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-HSA-190373:r:FGFR1c 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"R-DDI-437239", "R-CEL-437239", "R-DME-8866427", "R-DME-9013424", "R-SPO-8964038", "R-HSA-9725370", "R-MMU-190873", "R-CEL-5140745", "R-SCE-432720", "R-DDI-8866427", "R-RNO-190873", "R-MMU-8964038", "R-HSA-168275", "R-MMU-2132295", "R-BTA-437239", "R-BTA-8866427", "R-RNO-8856828", "R-DME-8856828", "R-SPO-9013420", "R-SCE-9013424", "R-RNO-5099900", "R-SCE-8964038", "R-HSA-432722", "R-SPO-432720", "R-BTA-2132295", "R-MMU-432720", "R-BTA-8856828", "R-HSA-196025", "R-CEL-8856828", "R-BTA-9013420", "R-RNO-2132295", "R-DME-8856825", "R-HSA-9013420", "R-RNO-8856825", "R-MMU-437239", "R-RNO-437239", "R-BTA-432720", "R-CEL-196025", "R-DDI-432720", "R-HSA-5099900", "R-DME-432722", "R-MMU-9013424", "R-SPO-8856828", "R-CEL-3928665", "R-HSA-177504", "R-HSA-8866427", "R-BTA-8856825", "R-BTA-8964038", "R-HSA-8856825", "R-HSA-3928665", "R-SCE-437239", "R-MMU-177504", "R-CEL-9013420", "R-BTA-432722", "R-BTA-5140745", "R-SCE-190873", "R-HSA-8964038", "R-DME-9013420"], "pathways": 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"R-DDI-8856828:r:Clathrin-mediated endocytosis", "R-SCE-9013420:r:RHOU GTPase cycle", "R-DME-3928665:r:EPH-ephrin mediated repulsion of cells", "R-DME-8964038:r:LDL clearance", "R-DDI-8964038:r:LDL clearance", "R-DME-177504:r:Retrograde neurotrophin signalling", "R-HSA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-RNO-8866427:r:VLDLR internalisation and degradation", "R-RNO-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-196025:r:Formation of annular gap junctions", "R-BTA-5099900:r:WNT5A-dependent internalization of FZD4", "R-RNO-432720:r:Lysosome Vesicle Biogenesis", "R-DME-437239:r:Recycling pathway of L1", "R-HSA-432720:r:Lysosome Vesicle Biogenesis", "R-DME-196025:r:Formation of annular gap junctions", "R-DME-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-HSA-437239:r:Recycling pathway of L1", "R-CEL-8866427:r:VLDLR internalisation and degradation", "R-BTA-177504:r:Retrograde neurotrophin signalling", "R-MMU-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SPO-8866427:r:VLDLR internalisation and degradation", "R-CEL-8964038:r:LDL clearance", "R-SPO-190873:r:Gap junction degradation", "R-MMU-8866427:r:VLDLR internalisation and degradation", "R-SPO-9013424:r:RHOV GTPase cycle", "R-SCE-196025:r:Formation of annular gap junctions", "R-SPO-196025:r:Formation of annular gap junctions", "R-RNO-9013420:r:RHOU GTPase cycle", "R-CEL-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-SCE-8866427:r:VLDLR internalisation and degradation", "R-HSA-2132295:r:MHC class II antigen presentation", "R-DME-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-190873:r:Gap junction degradation", "R-CEL-432720:r:Lysosome Vesicle Biogenesis", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-CEL-190873:r:Gap junction degradation", "R-DDI-437239:r:Recycling pathway of L1", "R-CEL-437239:r:Recycling pathway of L1", "R-DME-8866427:r:VLDLR internalisation and degradation", "R-DME-9013424:r:RHOV GTPase cycle", "R-SPO-8964038:r:LDL clearance", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-190873:r:Gap junction degradation", "R-CEL-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-432720:r:Lysosome Vesicle Biogenesis", "R-DDI-8866427:r:VLDLR internalisation and degradation", "R-RNO-190873:r:Gap junction degradation", "R-MMU-8964038:r:LDL clearance", "R-HSA-168275:r:Entry of Influenza Virion into Host Cell via Endocytosis", "R-MMU-2132295:r:MHC class II antigen presentation", "R-BTA-437239:r:Recycling pathway of L1", "R-BTA-8866427:r:VLDLR internalisation and degradation", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-DME-8856828:r:Clathrin-mediated endocytosis", "R-SPO-9013420:r:RHOU GTPase cycle", "R-SCE-9013424:r:RHOV GTPase cycle", "R-RNO-5099900:r:WNT5A-dependent internalization of FZD4", "R-SCE-8964038:r:LDL clearance", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis", "R-SPO-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-2132295:r:MHC class II antigen presentation", "R-MMU-432720:r:Lysosome Vesicle Biogenesis", "R-BTA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-196025:r:Formation of annular gap junctions", "R-CEL-8856828:r:Clathrin-mediated endocytosis", "R-BTA-9013420:r:RHOU GTPase cycle", "R-RNO-2132295:r:MHC class II antigen presentation", "R-DME-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-9013420:r:RHOU GTPase cycle", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-437239:r:Recycling pathway of L1", "R-RNO-437239:r:Recycling pathway of L1", "R-BTA-432720:r:Lysosome Vesicle Biogenesis", "R-CEL-196025:r:Formation of annular gap junctions", "R-DDI-432720:r:Lysosome Vesicle Biogenesis", "R-HSA-5099900:r:WNT5A-dependent internalization of FZD4", "R-DME-432722:r:Golgi Associated Vesicle Biogenesis", "R-MMU-9013424:r:RHOV GTPase cycle", "R-SPO-8856828:r:Clathrin-mediated endocytosis", "R-CEL-3928665:r:EPH-ephrin mediated repulsion of cells", "R-HSA-177504:r:Retrograde neurotrophin signalling", "R-HSA-8866427:r:VLDLR internalisation and degradation", "R-BTA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-BTA-8964038:r:LDL clearance", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3928665:r:EPH-ephrin mediated repulsion of cells", "R-SCE-437239:r:Recycling pathway of L1", "R-MMU-177504:r:Retrograde neurotrophin signalling", "R-CEL-9013420:r:RHOU GTPase cycle", "R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-BTA-5140745:r:WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "R-SCE-190873:r:Gap junction degradation", "R-HSA-8964038:r:LDL clearance", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Repeat"}, "IPR055360": {"description": "bAvd-like", "go_ids": [], "go_terms": [], "name": "bAvd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055362": {"description": "PTHB1, platform domain", "go_ids": [], "go_terms": [], "name": "PTHB1_pf_dom", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR055363": {"description": "PTHB1, hairpin domain", "go_ids": [], "go_terms": [], "name": "PTHB1_hp_dom", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR055364": {"description": "PTHB1, C-terminal helix bundle domain", "go_ids": [], "go_terms": [], "name": "PTHB1_CtH_dom", "pathway_ids": ["R-MMU-5620922", "R-HSA-5620922"], "pathways": ["R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR055365": {"description": "Sublancin immunity protein SunI-like, PH domain", "go_ids": [], "go_terms": [], "name": "PH_SunI-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055366": {"description": "Small VCP/p97-interacting protein, metazoa", "go_ids": [], "go_terms": [], "name": "SVIP_metazoa", "pathway_ids": ["R-MMU-6798695", "R-RNO-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Family"}, "IPR055367": {"description": "Large helicase-related protein, winged-helix domain 4", "go_ids": [], "go_terms": [], "name": "WH4_Lhr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055368": {"description": "Large helicase-related protein, winged-helix domain 3", "go_ids": [], "go_terms": [], "name": "WH3_Lhr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055369": {"description": "Large helicase-related protein, winged-helix domain 2", "go_ids": [], "go_terms": [], "name": "WH2_Lhr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055370": {"description": "Lsr2, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "Lsr2_DNA-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055371": {"description": "SpaA-like, prealbumin fold domain subgroup 4", "go_ids": [], "go_terms": [], "name": "SpaA_PFL_dom_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055372": {"description": "Carbohydrate-binding module family 96", "go_ids": [], "go_terms": [], "name": "CBM96", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055373": {"description": "Ribophorin II, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ribophorin_II_N", "pathway_ids": ["R-HSA-1799339", "R-RNO-9931295", "R-CFA-9768727", "R-MMU-9931295", "R-HSA-446203", "R-RNO-9768727", "R-HSA-9694548", "R-HSA-9918432", "R-CFA-9931295", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-9931295"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Domain"}, "IPR055374": {"description": "Ribophorin II, third domain", "go_ids": [], "go_terms": [], "name": "Ribophorin_II_3rd", "pathway_ids": ["R-HSA-1799339", "R-RNO-9931295", "R-CFA-9768727", "R-MMU-9931295", "R-HSA-446203", "R-RNO-9768727", "R-HSA-9694548", "R-HSA-9918432", "R-CFA-9931295", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-9931295"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Domain"}, "IPR055375": {"description": "Ribophorin II, second domain", "go_ids": [], "go_terms": [], "name": "Ribophorin_II_2nd", "pathway_ids": ["R-HSA-1799339", "R-RNO-9931295", "R-CFA-9768727", "R-MMU-9931295", "R-HSA-446203", "R-RNO-9768727", "R-HSA-9694548", "R-HSA-9918432", "R-CFA-9931295", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-9931295"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Domain"}, "IPR055377": {"description": "GH3, middle domain", "go_ids": [], "go_terms": [], "name": "GH3_M", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565", "R-MMU-6798695", "R-HSA-6798695"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR055378": {"description": "GH3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GH3_C", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565", "R-MMU-6798695", "R-HSA-6798695"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR055379": {"description": "BBS2, platform domain", "go_ids": [], "go_terms": [], "name": "BBS2_pf_dom", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922", "R-DRE-5620922", "R-RNO-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR055380": {"description": "BBS2, hairpin domain", "go_ids": [], "go_terms": [], "name": "BBS2_hp_dom", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922", "R-DRE-5620922", "R-RNO-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR055381": {"description": "BBS2, C-terminal helix bundle domain", "go_ids": [], "go_terms": [], "name": "BBS2_CtH_dom", "pathway_ids": ["R-HSA-5620922", "R-MMU-5620922", "R-DRE-5620922", "R-RNO-5620922"], "pathways": ["R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-DRE-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-RNO-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR055382": {"description": "Pilin, beta sandwich domain", "go_ids": [], "go_terms": [], "name": "Pilin_b-sandwich", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055383": {"description": "Tip attachment protein J, Fn3-1 domain", "go_ids": [], "go_terms": [], "name": "FN3-1_GpJ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055384": {"description": "Domain of unknown function DUF7604", "go_ids": [], "go_terms": [], "name": "DUF7604", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055385": {"description": "Tip attachment protein J, HDII-ins2 domain", "go_ids": [], "go_terms": [], "name": "GpJ_HDII-ins2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055386": {"description": "Fanconi anaemia group A protein, helical domain", "go_ids": [], "go_terms": [], "name": "FANCA_helical", "pathway_ids": ["R-HSA-6783310", "R-HSA-9833482", "R-MMU-9833482", "R-MMU-6783310"], "pathways": ["R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR055387": {"description": "Fanconi anaemia group A protein, arcN subdomain", "go_ids": [], "go_terms": [], "name": "FANCA_arcN", "pathway_ids": ["R-HSA-6783310", "R-HSA-9833482", "R-MMU-9833482", "R-MMU-6783310"], "pathways": ["R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-9833482:r:PKR-mediated signaling", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR055388": {"description": "Domain of unknown function DUF7617", "go_ids": [], "go_terms": [], "name": "DUF7617", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055389": {"description": "L-arabinose isomerase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AraA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055390": {"description": "L-arabinose isomerase, central domain", "go_ids": [], "go_terms": [], "name": "AraA_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055391": {"description": "BROMI, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BROMI_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055392": {"description": "BROMI, C-terminal Rab TBC-like domain", "go_ids": [], "go_terms": [], "name": "BROMI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055393": {"description": "EDC4-like protein pdc1, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_EDC4L", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055394": {"description": "TiaS, C-terminal zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_TiaS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055395": {"description": "Duc1 FFAT-like motif", "go_ids": [], "go_terms": [], "name": "Duc1_FFAT-like", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR055396": {"description": "Domain of unknown function DUF7088", "go_ids": [], "go_terms": [], "name": "DUF7088", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055397": {"description": "TraK, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TraK_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055398": {"description": "Bacillithiol biosynthesis BshC, N-terminal Rossmann-like domain", "go_ids": [], "go_terms": [], "name": "Rossmann-like_BshC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055399": {"description": "Bacillithiol biosynthesis BshC, C-terminal coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CC_BshC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055400": {"description": "CEMIP, domain X", "go_ids": [], "go_terms": [], "name": "CEMIP_X", "pathway_ids": ["PWY-6573", "R-MMU-2160916", "R-DDI-2160916", "R-HSA-2160916"], "pathways": ["PWY-6573:t:chondroitin sulfate degradation (metazoa)", "R-MMU-2160916:r:Hyaluronan degradation", "R-DDI-2160916:r:Hyaluronan degradation", "R-HSA-2160916:r:Hyaluronan degradation"], "type": "Domain"}, "IPR055401": {"description": "CEMIP, beta-helix domain", "go_ids": [], "go_terms": [], "name": "CEMIP_beta-hel_dom", "pathway_ids": ["R-MMU-2160916", "R-DDI-2160916", "R-HSA-2160916"], "pathways": ["R-MMU-2160916:r:Hyaluronan degradation", "R-DDI-2160916:r:Hyaluronan degradation", "R-HSA-2160916:r:Hyaluronan degradation"], "type": "Domain"}, "IPR055402": {"description": "KNTC1, N-terminal", "go_ids": [], "go_terms": [], "name": "KNTC1_N", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-5663220", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR055403": {"description": "KNTC1, first ARM-repeats domain", "go_ids": [], "go_terms": [], "name": "ARM_KNTC1_1st", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-5663220", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR055404": {"description": "KNTC1, second ARM-repeats domain", "go_ids": [], "go_terms": [], "name": "ARM_KNTC1_2nd", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-5663220", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR055405": {"description": "KNTC1, third ARM-repeats domain", "go_ids": [], "go_terms": [], "name": "ARM_KNTC1_3rd", "pathway_ids": ["R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-141444", "R-HSA-68877", "R-MMU-2467813", "R-MMU-9648025", "R-HSA-5663220", "R-HSA-141444", "R-HSA-9648025", "R-MMU-68877", "R-MMU-5663220"], "pathways": ["R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-68877:r:Mitotic Prometaphase", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-68877:r:Mitotic Prometaphase", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR055406": {"description": "Maestro/Maestro-like, HEAT-repeats domain", "go_ids": [], "go_terms": [], "name": "HEAT_Maestro", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055407": {"description": "Conjugative transposon TraM, C-terminal", "go_ids": [], "go_terms": [], "name": "TraM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055408": {"description": "MROH2B-like, HEAT-repeats domain", "go_ids": [], "go_terms": [], "name": "HEAT_MROH2B-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055409": {"description": "FAM234A/B, beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_FAM234A_B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055410": {"description": "CAF1B/HIR1, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_CAF1B_HIR1", "pathway_ids": ["R-SCE-2559584", "R-HSA-2559584", "R-HSA-9821993", "R-MMU-2559584", "R-CEL-2559584"], "pathways": ["R-SCE-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-9821993:r:Replacement of protamines by nucleosomes in the male pronucleus", "R-MMU-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-CEL-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Domain"}, "IPR055411": {"description": "F-box/LRR-repeat protein 15/At3g58940/PEG3-like, LRR domain", "go_ids": [], "go_terms": [], "name": "LRR_FXL15/At3g58940/PEG3-like", "pathway_ids": ["R-MMU-8951664", "R-MMU-983168", "R-RNO-8951664", "R-RNO-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR055412": {"description": "Root UVB sensitive protein, C-terminal", "go_ids": [], "go_terms": [], "name": "UVB_sens_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055413": {"description": "Matrix protein, C-terminal, Paramyxoviridae", "go_ids": [], "go_terms": [], "name": "Matrix_Paramyxo_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055414": {"description": "Disease resistance R13L4/SHOC-2-like, LRR domain", "go_ids": [], "go_terms": [], "name": "LRR_R13L4/SHOC2-like", "pathway_ids": ["R-HSA-9013409", "R-DDI-354192", "R-HSA-6798695", "R-MMU-9013106", "R-HSA-9665251", "R-DDI-6803207", "R-MMU-9013408", "R-CEL-5673000", "R-MMU-9013404", "R-MMU-446388", "R-RNO-5223345", "R-HSA-442982", "R-DDI-8951664", "R-DRE-9013406", "R-DDI-5675482", "R-DDI-170968", "R-HSA-5673000", "R-DDI-5213460", "R-HSA-8863795", "R-MMU-9652282", "R-DDI-5673000", "R-DDI-9013423", "R-HSA-9013408", "R-HSA-9665247", "R-HSA-9664565", "R-RNO-5673001", "R-DRE-9696270", "R-DME-438066", "R-MMU-5673001", "R-HSA-5223345", "R-HSA-9652282", "R-DDI-193648", "R-RNO-5673000", "R-HSA-9665244", "R-HSA-9665686", "R-MMU-438066", "R-MMU-5673000", "R-DDI-5223345", "R-DDI-5673001", "R-DRE-5673000", "R-RNO-438066", "R-HSA-9696264", "R-HSA-5673001", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-CEL-5223345", "R-HSA-8980692", "R-HSA-4608870", "R-DDI-5674135", "R-HSA-9620244", "R-MMU-9013406", "R-HSA-9726840", "R-HSA-9013026", "R-MMU-6798695", "R-MMU-9696264", "R-MMU-199418", "R-BTA-5673000", "R-HSA-9609736", "R-RNO-6798695", "R-MMU-8863795", "R-DDI-446388", "R-DDI-199418", "R-MMU-8980692", "R-HSA-9665737", "R-HSA-9665348", "R-DDI-5674499", "R-HSA-9013106", "R-DDI-9013149", "R-HSA-9665245", "R-HSA-9013423", "R-DDI-381676", "R-DRE-9696264", "R-HSA-9013148", "R-DME-9013406", "R-HSA-9617324", "R-DDI-5689880", "R-DDI-171007", "R-HSA-9665249", "R-HSA-9696270", "R-DDI-3295583", "R-MMU-5223345", "R-DME-6798695", "R-HSA-9665246", "R-MMU-1227986", "R-DDI-392517", "R-HSA-1227986", "R-HSA-9665233", "R-HSA-983168", "R-HSA-9665250", "R-DDI-5675221", "R-HSA-9726842", "R-DDI-5621575", "R-DDI-983168", "R-DME-5223345", "R-DRE-9013148", "R-HSA-438066", "R-HSA-9634285", "R-MMU-9013026", "R-DDI-168638", "R-HSA-446388", "R-HSA-9013406", "R-DDI-9013404", "R-MMU-9696270", "R-MMU-9013149", "R-DDI-1169092"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-DDI-354192:r:Integrin signaling", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-9013106:r:RHOC GTPase cycle", "R-HSA-9665251:r:Resistance of ERBB2 KD mutants to lapatinib", "R-DDI-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-MMU-9013408:r:RHOG GTPase cycle", "R-CEL-5673000:r:RAF activation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-RNO-5223345:r:Miscellaneous transport and binding events", "R-HSA-442982:r:Ras activation upon Ca2+ influx through NMDA receptor", "R-DDI-8951664:r:Neddylation", "R-DRE-9013406:r:RHOQ GTPase cycle", "R-DDI-5675482:r:Regulation of necroptotic cell death", "R-DDI-170968:r:Frs2-mediated activation", "R-HSA-5673000:r:RAF activation", "R-DDI-5213460:r:RIPK1-mediated regulated necrosis", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DDI-5673000:r:RAF activation", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9665247:r:Resistance of ERBB2 KD mutants to osimertinib", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-DRE-9696270:r:RND2 GTPase cycle", "R-DME-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-5223345:r:Miscellaneous transport and binding events", "R-HSA-9652282:r:Drug-mediated inhibition of ERBB2 signaling", "R-DDI-193648:r:NRAGE signals death through JNK", "R-RNO-5673000:r:RAF activation", "R-HSA-9665244:r:Resistance of ERBB2 KD mutants to sapitinib", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-MMU-5673000:r:RAF activation", "R-DDI-5223345:r:Miscellaneous transport and binding events", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-DRE-5673000:r:RAF activation", "R-RNO-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-CEL-5223345:r:Miscellaneous transport and binding events", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-9620244:r:Long-term potentiation", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-HSA-9726840:r:SHOC2 M1731 mutant abolishes MRAS complex function", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-199418:r:Negative regulation of the PI3K/AKT network", "R-BTA-5673000:r:RAF activation", "R-HSA-9609736:r:Assembly and cell surface presentation of NMDA receptors", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-DDI-199418:r:Negative regulation of the PI3K/AKT network", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-9665737:r:Drug resistance in ERBB2 TMD/JMD mutants", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-DDI-5674499:r:Negative feedback regulation of MAPK pathway", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9665245:r:Resistance of ERBB2 KD mutants to tesevatinib", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DRE-9696264:r:RND3 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-HSA-9617324:r:Negative regulation of NMDA receptor-mediated neuronal transmission", "R-DDI-5689880:r:Ub-specific processing proteases", "R-DDI-171007:r:p38MAPK events", "R-HSA-9665249:r:Resistance of ERBB2 KD mutants to afatinib", "R-HSA-9696270:r:RND2 GTPase cycle", "R-DDI-3295583:r:TRP channels", "R-MMU-5223345:r:Miscellaneous transport and binding events", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9665246:r:Resistance of ERBB2 KD mutants to neratinib", "R-MMU-1227986:r:Signaling by ERBB2", "R-DDI-392517:r:Rap1 signalling", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-9665233:r:Resistance of ERBB2 KD mutants to trastuzumab", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9665250:r:Resistance of ERBB2 KD mutants to AEE788", "R-DDI-5675221:r:Negative regulation of MAPK pathway", "R-HSA-9726842:r:Gain-of-function MRAS complexes activate RAF signaling", "R-DDI-5621575:r:CD209 (DC-SIGN) signaling", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-5223345:r:Miscellaneous transport and binding events", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-438066:r:Unblocking of NMDA receptors, glutamate binding and activation", "R-HSA-9634285:r:Constitutive Signaling by Overexpressed ERBB2", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DDI-168638:r:NOD1/2 Signaling Pathway", "R-HSA-446388:r:Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DDI-1169092:r:Activation of RAS in B cells"], "type": "Domain"}, "IPR055415": {"description": "SV2A/B/C, luminal domain", "go_ids": [], "go_terms": [], "name": "LD_SV2", "pathway_ids": ["R-HSA-5250968", "R-HSA-5250992", "R-HSA-5250955", "R-HSA-5250981"], "pathways": ["R-HSA-5250968:r:Toxicity of botulinum toxin type A (botA)", "R-HSA-5250992:r:Toxicity of botulinum toxin type E (botE)", "R-HSA-5250955:r:Toxicity of botulinum toxin type D (botD)", "R-HSA-5250981:r:Toxicity of botulinum toxin type F (botF)"], "type": "Domain"}, "IPR055416": {"description": "Leucine--tRNA ligase, RagD-binding domain", "go_ids": [], "go_terms": [], "name": "RBD_LARS1", "pathway_ids": ["R-MMU-9856649", "R-HSA-9856649", "R-DDI-9856649", "R-HSA-2408522", "R-HSA-379716"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DDI-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism", "R-HSA-379716:r:Cytosolic tRNA aminoacylation"], "type": "Domain"}, "IPR055417": {"description": "Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 1", "go_ids": [], "go_terms": [], "name": "UFD1_N1", "pathway_ids": ["R-DDI-9755511", "R-CEL-9755511", "R-HSA-8951664", "R-HSA-5689880", "R-RNO-9755511", "R-MMU-110320", "R-DME-8951664", "R-DME-110320", "R-SCE-9755511", "R-HSA-9918487", "R-HSA-9755511", "R-MMU-9755511", "R-RNO-110320", "R-SPO-9755511", "R-DDI-8951664", "R-RNO-5689880", "R-DME-9755511", "R-MMU-8951664", "R-MMU-5689880", "R-SCE-8951664", "R-CEL-5689880", "R-CEL-110320", "R-SPO-110320", "R-HSA-9954709", "R-RNO-8951664", "R-SPO-8951664", "R-HSA-110320", "R-DME-5689880", "R-CEL-8951664"], "pathways": ["R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-DME-8951664:r:Neddylation", "R-DME-110320:r:Translesion Synthesis by POLH", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-8951664:r:Neddylation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-8951664:r:Neddylation", "R-CEL-5689880:r:Ub-specific processing proteases", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR055418": {"description": "Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 2", "go_ids": [], "go_terms": [], "name": "UFD1_N2", "pathway_ids": ["R-DDI-9755511", "R-CEL-9755511", "R-HSA-8951664", "R-HSA-5689880", "R-RNO-9755511", "R-MMU-110320", "R-DME-8951664", "R-DME-110320", "R-SCE-9755511", "R-HSA-9918487", "R-HSA-9755511", "R-MMU-9755511", "R-RNO-110320", "R-SPO-9755511", "R-DDI-8951664", "R-RNO-5689880", "R-DME-9755511", "R-MMU-8951664", "R-MMU-5689880", "R-SCE-8951664", "R-CEL-5689880", "R-CEL-110320", "R-SPO-110320", "R-HSA-9954709", "R-RNO-8951664", "R-SPO-8951664", "R-HSA-110320", "R-DME-5689880", "R-CEL-8951664"], "pathways": ["R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-110320:r:Translesion Synthesis by POLH", "R-DME-8951664:r:Neddylation", "R-DME-110320:r:Translesion Synthesis by POLH", "R-SCE-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-RNO-110320:r:Translesion Synthesis by POLH", "R-SPO-9755511:r:KEAP1-NFE2L2 pathway", "R-DDI-8951664:r:Neddylation", "R-RNO-5689880:r:Ub-specific processing proteases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8951664:r:Neddylation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-SCE-8951664:r:Neddylation", "R-CEL-5689880:r:Ub-specific processing proteases", "R-CEL-110320:r:Translesion Synthesis by POLH", "R-SPO-110320:r:Translesion Synthesis by POLH", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-8951664:r:Neddylation", "R-SPO-8951664:r:Neddylation", "R-HSA-110320:r:Translesion Synthesis by POLH", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR055419": {"description": "Periplakin/Envoplakin, N-terminal", "go_ids": [], "go_terms": [], "name": "Spectrin_PEPL/EVPL", "pathway_ids": ["R-HSA-8851680", "R-MMU-8851680", "R-MMU-6809371", "R-HSA-6809371"], "pathways": ["R-HSA-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-8851680:r:Butyrophilin (BTN) family interactions", "R-MMU-6809371:r:Formation of the cornified envelope", "R-HSA-6809371:r:Formation of the cornified envelope"], "type": "Domain"}, "IPR055420": {"description": "Trafficking protein particle complex II-specific subunit 65, IgD3", "go_ids": [], "go_terms": [], "name": "IgD3_Trs65", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055421": {"description": "Transmembrane protein TMEM132, cohesin-like domain", "go_ids": [], "go_terms": [], "name": "TMEM132_3rd", "pathway_ids": ["R-RNO-381426", "R-MMU-381426", "R-HSA-8957275", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426", "R-DRE-8957275", "R-DRE-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR055422": {"description": "Transmembrane protein TMEM132, second Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TMEM132_2nd", "pathway_ids": ["R-RNO-381426", "R-MMU-381426", "R-HSA-8957275", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426", "R-DRE-8957275", "R-DRE-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8957275:r:Post-translational protein phosphorylation", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR055423": {"description": "Transmembrane protein TMEM132, fifth domain", "go_ids": [], "go_terms": [], "name": "Ig_TMEM132_5th", "pathway_ids": ["R-RNO-381426", "R-RNO-8957275", "R-MMU-381426", "R-DRE-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-DRE-8957275"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8957275:r:Post-translational protein phosphorylation"], "type": "Domain"}, "IPR055424": {"description": "Transmembrane protein TMEM132, sixth domain", "go_ids": [], "go_terms": [], "name": "Ig_TMEM132_6th", "pathway_ids": ["R-RNO-381426", "R-RNO-8957275", "R-MMU-381426", "R-DRE-381426", "R-CEL-381426", "R-CEL-8957275", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426", "R-DRE-8957275"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DRE-8957275:r:Post-translational protein phosphorylation"], "type": "Domain"}, "IPR055425": {"description": "Trafficking protein particle complex II-specific subunit 65, IgD1", "go_ids": [], "go_terms": [], "name": "IgD1_Trs65", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055426": {"description": "Trafficking protein particle complex II-specific subunit 65, IgD2", "go_ids": [], "go_terms": [], "name": "IgD2_Trs65", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055427": {"description": "Trafficking protein particle complex subunit 13, N-terminal", "go_ids": [], "go_terms": [], "name": "TRAPPC13_N", "pathway_ids": ["R-RNO-8876198", "R-HSA-8876198", "R-MMU-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-DME-8876198", "R-DRE-8876198"], "pathways": ["R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR055428": {"description": "Trafficking protein particle complex subunit 13, C-terminal", "go_ids": [], "go_terms": [], "name": "TRAPPC13_C", "pathway_ids": ["R-RNO-8876198", "R-HSA-8876198", "R-MMU-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-DME-8876198", "R-DRE-8876198"], "pathways": ["R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR055429": {"description": "Trafficking protein particle complex subunit 13, middle domain", "go_ids": [], "go_terms": [], "name": "TRAPPC13_M", "pathway_ids": ["R-RNO-8876198", "R-HSA-8876198", "R-MMU-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-DME-8876198", "R-DRE-8876198"], "pathways": ["R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DDI-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR055430": {"description": "Pre-mRNA-splicing factor Syf1/CRNKL1-like, C-terminal HAT-repeats domain", "go_ids": [], "go_terms": [], "name": "HAT_Syf1_CNRKL1_C", "pathway_ids": ["R-DDI-6782135", "R-RNO-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-DME-6781823", "R-MMU-72163", "R-RNO-6782135", "R-DME-6791226", "R-DDI-6781823", "R-DME-72163", "R-RNO-72163", "R-DDI-6782210", "R-HSA-6782135", "R-DDI-72163", "R-HSA-6781823", "R-SCE-6782135", "R-HSA-72163", "R-MMU-6781823", "R-SPO-6782210", "R-HSA-6782210", "R-DME-6782210", "R-MMU-6782210", "R-SPO-6782135", "R-SCE-6782210", "R-SPO-72163", "R-DME-6782135", "R-HSA-9918481", "R-RNO-6782210"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER"], "type": "Domain"}, "IPR055431": {"description": "Anti-sigma factor RsgI-like, middle domain", "go_ids": [], "go_terms": [], "name": "RsgI_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055432": {"description": "STING, ligand-binding domain", "go_ids": [], "go_terms": [], "name": "STING_LBD", "pathway_ids": ["R-HSA-3270619", "R-DRE-3249367", "R-RNO-3270619", "R-XTR-3249367", "R-HSA-6798695", "R-MMU-3270619", "R-HSA-9705671", "R-HSA-9920588", "R-DME-6798695", "R-HSA-1834941", "R-MMU-3134975", "R-BTA-6798695", "R-BTA-3249367", "R-DME-1834941", "R-XTR-6798695", "R-MMU-1834941", "R-DRE-1834941", "R-DME-3134975", "R-BTA-1834941", "R-MMU-3249367", "R-BTA-3270619", "R-RNO-1834941", "R-DRE-6798695", "R-DRE-3134975", "R-HSA-3249367", "R-HSA-3134975", "R-HSA-9692916", "R-RNO-3134975", "R-MMU-6798695", "R-DME-3249367", "R-RNO-3249367", "R-XTR-1834941", "R-RNO-6798695", "R-BTA-3134975"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DRE-3249367:r:STAT6-mediated induction of chemokines", "R-RNO-3270619:r:IRF3-mediated induction of type I IFN", "R-XTR-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-3249367:r:STAT6-mediated induction of chemokines", "R-DME-1834941:r:STING mediated induction of host immune responses", "R-XTR-6798695:r:Neutrophil degranulation", "R-MMU-1834941:r:STING mediated induction of host immune responses", "R-DRE-1834941:r:STING mediated induction of host immune responses", "R-DME-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-1834941:r:STING mediated induction of host immune responses", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-BTA-3270619:r:IRF3-mediated induction of type I IFN", "R-RNO-1834941:r:STING mediated induction of host immune responses", "R-DRE-6798695:r:Neutrophil degranulation", "R-DRE-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-RNO-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-3249367:r:STAT6-mediated induction of chemokines", "R-RNO-3249367:r:STAT6-mediated induction of chemokines", "R-XTR-1834941:r:STING mediated induction of host immune responses", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA"], "type": "Domain"}, "IPR055433": {"description": "Pre-mRNA-splicing factor Syf1-like, N-terminal HAT-repeats domain", "go_ids": [], "go_terms": [], "name": "HAT_Syf1-like_N", "pathway_ids": ["R-DDI-6782135", "R-RNO-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-DME-6781823", "R-MMU-72163", "R-RNO-6782135", "R-DDI-6781823", "R-DME-72163", "R-RNO-72163", "R-DDI-6782210", "R-HSA-6782135", "R-DDI-72163", "R-HSA-6781823", "R-SCE-6782135", "R-HSA-72163", "R-MMU-6781823", "R-SPO-6782210", "R-HSA-6782210", "R-DME-6782210", "R-MMU-6782210", "R-SPO-6782135", "R-SCE-6782210", "R-SPO-72163", "R-DME-6782135", "R-HSA-9918481", "R-RNO-6782210"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER"], "type": "Domain"}, "IPR055434": {"description": "STING, transmembrane domain", "go_ids": [], "go_terms": [], "name": "STING_TM", "pathway_ids": ["R-HSA-3270619", "R-DRE-3249367", "R-RNO-3270619", "R-XTR-3249367", "R-HSA-6798695", "R-MMU-3270619", "R-HSA-9705671", "R-HSA-9920588", "R-DME-6798695", "R-HSA-1834941", "R-MMU-3134975", "R-BTA-6798695", "R-BTA-3249367", "R-DME-1834941", "R-XTR-6798695", "R-MMU-1834941", "R-DRE-1834941", "R-DME-3134975", "R-BTA-1834941", "R-MMU-3249367", "R-BTA-3270619", "R-RNO-1834941", "R-DRE-6798695", "R-DRE-3134975", "R-HSA-3249367", "R-HSA-3134975", "R-HSA-9692916", "R-RNO-3134975", "R-MMU-6798695", "R-DME-3249367", "R-RNO-3249367", "R-XTR-1834941", "R-RNO-6798695", "R-BTA-3134975"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN", "R-DRE-3249367:r:STAT6-mediated induction of chemokines", "R-RNO-3270619:r:IRF3-mediated induction of type I IFN", "R-XTR-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-3270619:r:IRF3-mediated induction of type I IFN", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-1834941:r:STING mediated induction of host immune responses", "R-MMU-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-6798695:r:Neutrophil degranulation", "R-BTA-3249367:r:STAT6-mediated induction of chemokines", "R-DME-1834941:r:STING mediated induction of host immune responses", "R-XTR-6798695:r:Neutrophil degranulation", "R-MMU-1834941:r:STING mediated induction of host immune responses", "R-DRE-1834941:r:STING mediated induction of host immune responses", "R-DME-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-BTA-1834941:r:STING mediated induction of host immune responses", "R-MMU-3249367:r:STAT6-mediated induction of chemokines", "R-BTA-3270619:r:IRF3-mediated induction of type I IFN", "R-RNO-1834941:r:STING mediated induction of host immune responses", "R-DRE-6798695:r:Neutrophil degranulation", "R-DRE-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-3249367:r:STAT6-mediated induction of chemokines", "R-HSA-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-RNO-3134975:r:Regulation of innate immune responses to cytosolic DNA", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-3249367:r:STAT6-mediated induction of chemokines", "R-RNO-3249367:r:STAT6-mediated induction of chemokines", "R-XTR-1834941:r:STING mediated induction of host immune responses", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-3134975:r:Regulation of innate immune responses to cytosolic DNA"], "type": "Domain"}, "IPR055435": {"description": "TMEM131L, third Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TMEM131L_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055436": {"description": "TMEM131L, fourth Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TMEM131L_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055437": {"description": "TMEM131L, fifth Ig-like domain", "go_ids": [], "go_terms": [], "name": "TMEM131L_Ig_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055438": {"description": "Succinylglutamate desuccinylase/Aspartoacylase, catalytic domain", "go_ids": ["GO:0016788"], "go_terms": ["GO:0016788:hydrolase activity, acting on ester bonds:F"], "name": "AstE_AspA_cat", "pathway_ids": ["R-MMU-5423646", "R-XTR-8963693", "R-RNO-5423646", "R-MMU-8963693", "R-HSA-8963693", "R-XTR-5423646", "R-HSA-5423646", "R-RNO-8963693", "R-DRE-5423646", "R-DRE-8963693"], "pathways": ["R-MMU-5423646:r:Aflatoxin activation and detoxification", "R-XTR-8963693:r:Aspartate and asparagine metabolism", "R-RNO-5423646:r:Aflatoxin activation and detoxification", "R-MMU-8963693:r:Aspartate and asparagine metabolism", "R-HSA-8963693:r:Aspartate and asparagine metabolism", "R-XTR-5423646:r:Aflatoxin activation and detoxification", "R-HSA-5423646:r:Aflatoxin activation and detoxification", "R-RNO-8963693:r:Aspartate and asparagine metabolism", "R-DRE-5423646:r:Aflatoxin activation and detoxification", "R-DRE-8963693:r:Aspartate and asparagine metabolism"], "type": "Domain"}, "IPR055439": {"description": "EML-like, first beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_EML_1st", "pathway_ids": ["R-XTR-9648025", "R-DME-9648025", "R-HSA-9648025", "R-MMU-9648025", "R-HSA-9700645", "R-HSA-9725370"], "pathways": ["R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Domain"}, "IPR055440": {"description": "WDR90, 4th beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_WDR90_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055441": {"description": "WDR90/POC16, second beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_WDR90_POC16_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055442": {"description": "EML-like, second beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_EML-like_2nd", "pathway_ids": ["R-XTR-9648025", "R-DME-9648025", "R-HSA-9700645", "R-DME-674695", "R-DME-76042", "R-DME-73779", "R-HSA-9648025", "R-DME-380972", "R-DME-6804756", "R-DME-5218920", "R-DME-6807505", "R-DME-73776", "R-DME-9907900", "R-DME-3371571", "R-DME-166208", "R-DME-1257604", "R-DME-1632852", "R-DME-8943724", "R-DME-75953", "R-DME-165159", "R-MMU-9648025", "R-HSA-9725370", "R-DME-389357", "R-DME-9856530", "R-DME-5628897", "R-DME-9639288"], "pathways": ["R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-5218920:r:VEGFR2 mediated vascular permeability", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-DME-9907900:r:Proteasome assembly", "R-DME-3371571:r:HSF1-dependent transactivation", "R-DME-166208:r:mTORC1-mediated signalling", "R-DME-1257604:r:PIP3 activates AKT signaling", "R-DME-1632852:r:Macroautophagy", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-DME-165159:r:MTOR signalling", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DME-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DME-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR055443": {"description": "Proteasome adapter and scaffold protein ECM29, HEAT-repeat domain", "go_ids": [], "go_terms": [], "name": "HEAT_ECM29", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055444": {"description": "ECM29, ARM-like repeats domain", "go_ids": [], "go_terms": [], "name": "ARM_ECM29", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055445": {"description": "ARMC5-like, ARM-repeats domain", "go_ids": [], "go_terms": [], "name": "ARM_ARMC5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055446": {"description": "ATP-dependent RecD2 DNA helicase, OB-fold domain", "go_ids": [], "go_terms": [], "name": "RecD2_N_OB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055447": {"description": "Spike glycoprotein G, central domain, rhabdovirus", "go_ids": [], "go_terms": [], "name": "Rhabdo_glycop_CD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055448": {"description": "Glycoprotein G, PH domain, rhabdovirus", "go_ids": [], "go_terms": [], "name": "PH_Rhabdo_glycop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055449": {"description": "INO80 complex subunit 3-like, middle region", "go_ids": [], "go_terms": [], "name": "Iec3-like_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055450": {"description": "AP-5 complex subunit zeta-1, ARM repeats domain", "go_ids": [], "go_terms": [], "name": "AP5Z1_ARM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055451": {"description": "CATSPERD, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig-like_CATSPERD", "pathway_ids": ["R-MMU-1300642", "R-RNO-1300642", "R-HSA-1300642"], "pathways": ["R-MMU-1300642:r:Sperm Motility And Taxes", "R-RNO-1300642:r:Sperm Motility And Taxes", "R-HSA-1300642:r:Sperm Motility And Taxes"], "type": "Domain"}, "IPR055452": {"description": "TRAPP14, C-terminal", "go_ids": [], "go_terms": [], "name": "TRAPP14_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055453": {"description": "TRAPP14, N-terminal", "go_ids": [], "go_terms": [], "name": "TRAPP14_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR055454": {"description": "CCR4-NOT transcription complex subunit 1-like, NOT1 connector", "go_ids": [], "go_terms": [], "name": "CNOT1-like_NOT1_connector", "pathway_ids": ["R-XTR-429947", "R-MMU-6804115", "R-HSA-6804115", "R-XTR-6804115", "R-DRE-6804115", "R-HSA-429947", "R-MMU-429947", "R-HSA-9820841"], "pathways": ["R-XTR-429947:r:Deadenylation of mRNA", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-XTR-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-429947:r:Deadenylation of mRNA", "R-MMU-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors"], "type": "Domain"}, "IPR055455": {"description": "Proteasome activator complex subunit 4-like, HEAT repeat-like", "go_ids": [], "go_terms": [], "name": "HEAT_PSME4", "pathway_ids": ["R-HSA-9907900"], "pathways": ["R-HSA-9907900:r:Proteasome assembly"], "type": "Domain"}, "IPR055457": {"description": "OST48, N-terminal domain", "go_ids": [], "go_terms": [], "name": "OST48_N", "pathway_ids": ["R-HSA-1799339", 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degranulation", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Domain"}, "IPR055458": {"description": "IFT52, GIFT domain", "go_ids": [], "go_terms": [], "name": "IFT52_GIFT", "pathway_ids": ["R-MMU-5610787", "R-MMU-5620924", "R-HSA-5610787", "R-HSA-5620924"], "pathways": ["R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar 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formation", "R-SPO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-SSC-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-5689880:r:Ub-specific processing proteases", "R-RNO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-SSC-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SCE-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-SSC-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-176417:r:Phosphorylation of Emi1", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SSC-68877:r:Mitotic Prometaphase", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-RNO-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SSC-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-RNO-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-68877:r:Mitotic Prometaphase", "R-SSC-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-SSC-5689880:r:Ub-specific processing proteases", "R-SCE-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SSC-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-RNO-68877:r:Mitotic Prometaphase", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-176417:r:Phosphorylation of Emi1", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-SSC-2467813:r:Separation of Sister Chromatids", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-CEL-5689880:r:Ub-specific processing proteases", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-SSC-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-RNO-141405:r:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "R-SSC-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-176417:r:Phosphorylation of Emi1"], "type": "Domain"}, "IPR056151": {"description": "DDB1- and CUL4-associated factor 12, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_DCAF12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056152": {"description": "IFT122, second beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_IFT122_2nd", "pathway_ids": ["R-XTR-5610787", "R-MMU-5620924", "R-HSA-5610787", "R-HSA-5620924", "R-XTR-5620924", "R-MMU-5610787", "R-CEL-5620924", "R-CEL-5610787"], "pathways": ["R-XTR-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-XTR-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-CEL-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR056153": {"description": "IFT122/SMU1, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "IFT122/SMU1_beta-prop", "pathway_ids": ["R-MMU-983168", "R-SPO-73779", "R-MMU-6798695", "R-HSA-2644606", "R-XTR-5620924", "R-SPO-6791226", "R-RNO-6798695", "R-BTA-983168", "R-HSA-6798695", "R-BTA-8951664", "R-SPO-674695", "R-HSA-9604323", "R-SPO-9907900", "R-DDI-165159", "R-HSA-8951664", "R-DDI-6791226", "R-SPO-6807505", "R-DRE-111458", "R-HSA-8953750", "R-DRE-9627069", "R-HSA-6790901", "R-MMU-111459", "R-DDI-6804757", "R-DRE-75955", "R-MMU-8951664", "R-SPO-76042", "R-RNO-111458", "R-MMU-9627069", "R-CEL-5610787", "R-DRE-6798695", "R-HSA-5610787", "R-MMU-5610787", "R-DDI-5218920", "R-XTR-5610787", "R-HSA-9627069", "R-HSA-111463", "R-HSA-2122947", "R-MMU-5620924", "R-SPO-73776", "R-SPO-75953", "R-BTA-72163", "R-HSA-111459", "R-DDI-9639288", "R-DDI-5628897", "R-MMU-6791226", "R-DDI-1632852", "R-XTR-674695", "R-HSA-5620924", "R-DRE-111459", "R-XTR-429958", "R-HSA-6803207", "R-DDI-1257604", "R-MMU-72163", "R-HSA-390471", "R-DRE-429958", "R-HSA-2894862", "R-DDI-166208", "R-HSA-111464", "R-HSA-111458", "R-MMU-111458", "R-DDI-380972", "R-XTR-112382", "R-CEL-5620924", "R-DDI-3371571", "R-XTR-75955", "R-HSA-983168", "R-RNO-111459", "R-HSA-72163", "R-DDI-8943724", "R-DDI-9856530", "R-DRE-674695", "R-HSA-2644607", "R-HSA-6791226", "R-RNO-9627069", "R-XTR-8866654", "R-DDI-389357"], "pathways": ["R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-XTR-5620924:r:Intraflagellar transport", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-6798695:r:Neutrophil degranulation", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-8951664:r:Neddylation", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-SPO-9907900:r:Proteasome assembly", "R-DDI-165159:r:MTOR signalling", "R-HSA-8951664:r:Neddylation", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-111458:r:Formation of apoptosome", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-DRE-9627069:r:Regulation of the apoptosome activity", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-MMU-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-8951664:r:Neddylation", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-RNO-111458:r:Formation of apoptosome", "R-MMU-9627069:r:Regulation of the apoptosome activity", "R-CEL-5610787:r:Hedgehog 'off' state", "R-DRE-6798695:r:Neutrophil degranulation", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-XTR-5610787:r:Hedgehog 'off' state", "R-HSA-9627069:r:Regulation of the apoptosome activity", "R-HSA-111463:r:SMAC (DIABLO) binds to IAPs", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-5620924:r:Intraflagellar transport", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-HSA-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-1632852:r:Macroautophagy", "R-XTR-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-5620924:r:Intraflagellar transport", "R-DRE-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-XTR-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-HSA-390471:r:Association of TriC/CCT with target proteins during biosynthesis", "R-DRE-429958:r:mRNA decay by 3' to 5' exoribonuclease", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-DDI-166208:r:mTORC1-mediated signalling", "R-HSA-111464:r:SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes", "R-HSA-111458:r:Formation of apoptosome", "R-MMU-111458:r:Formation of apoptosome", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-XTR-112382:r:Formation of RNA Pol II elongation complex", "R-CEL-5620924:r:Intraflagellar transport", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-XTR-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-2644607:r:Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-9627069:r:Regulation of the apoptosome activity", "R-XTR-8866654:r:E3 ubiquitin ligases ubiquitinate target proteins", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling"], "type": "Domain"}, "IPR056154": {"description": "IFT140, first beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_IFT140_1st", "pathway_ids": ["R-MMU-5610787", "R-MMU-5620924", "R-HSA-5610787", "R-HSA-5620924"], "pathways": ["R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR056155": {"description": "IFT140, second beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_IFT140_2nd", "pathway_ids": ["R-MMU-5610787", "R-MMU-5620924", "R-HSA-5610787", "R-HSA-5620924"], "pathways": ["R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR056156": {"description": "IF140, C-terminal TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_IF140_C", "pathway_ids": ["R-MMU-5610787", "R-MMU-5620924", "R-HSA-5610787", "R-HSA-5620924"], "pathways": ["R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR056157": {"description": "IFT80/172/WDR35, TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_IFT80_172_dom", "pathway_ids": ["R-DRE-5610787", "R-HSA-5620924", "R-CEL-5610787", "R-HSA-5610787", "R-MMU-5610787", "R-DME-5610787", "R-RNO-5610787", "R-RNO-5620924", "R-CEL-5620924", "R-MMU-5620924"], "pathways": ["R-DRE-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-5610787:r:Hedgehog 'off' state", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR056158": {"description": "IFT121, second beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_IFT121_2nd", "pathway_ids": ["R-MMU-5620924", "R-RNO-5610787", "R-RNO-5620924", "R-HSA-5620924", "R-HSA-5610787", "R-MMU-5610787"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR056159": {"description": "IFT121/TULP4, N-terminal", "go_ids": [], "go_terms": [], "name": "Beta-prop_IFT121_TULP_N", "pathway_ids": ["R-MMU-8951664", "R-HSA-5620924", "R-HSA-5610787", "R-MMU-5610787", "R-HSA-8951664", "R-RNO-5610787", "R-RNO-5620924", "R-MMU-5620924"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-8951664:r:Neddylation", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR056160": {"description": "Leucine-rich repeat and WD repeat-containing protein 1, WD domain", "go_ids": [], "go_terms": [], "name": "WD_LRWD1", 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"R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Domain"}, "IPR056219": {"description": "THSD1, third Ig-like domain", "go_ids": [], "go_terms": [], "name": "THSD1_D3", "pathway_ids": ["R-MMU-5173214", "R-HSA-5083635", "R-HSA-5173214"], "pathways": ["R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Domain"}, "IPR056220": {"description": "Paratox-like", "go_ids": [], "go_terms": [], "name": "Paratox-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056221": {"description": "T6SS, Tle3 phospholipase effector, alpha/beta domain", "go_ids": [], "go_terms": [], "name": "Tle3_ab_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056222": {"description": "PH domain", "go_ids": [], "go_terms": [], "name": "PH_23", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056223": {"description": "PH domain, EVH1-like", "go_ids": [], "go_terms": [], "name": "PH_24", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056224": {"description": "FIGL1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FIGL1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056225": {"description": "Neuron-derived neurotrophic factor, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NDNF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056226": {"description": "PARP12, winged helix domain", "go_ids": [], "go_terms": [], "name": "WH_PARP12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056227": {"description": "ABC transporter, TMD0 domain", "go_ids": [], "go_terms": [], "name": "TMD0_ABC", "pathway_ids": ["PWY-8259", "PWY-8301", "PWY-4061", "PWY-6842", "PWY-4621", "R-HSA-2142691", "R-SCE-382556", "R-MMU-9753281", "R-SPO-2142691", "R-DDI-2142845", "R-RNO-9753281", "R-DDI-1660661", "R-RNO-382556", "R-SCE-9754706", "R-SCE-9707564", "R-MMU-189483", "R-RNO-9758890", "R-HSA-9707564", "R-SCE-2142691", "R-SPO-189483", "R-MMU-9749641", "R-RNO-189483", "R-CFA-9707564", "R-SPO-9754706", "R-HSA-5679001", "R-BTA-2142691", "R-CFA-382556", "R-SPO-9758890", "R-HSA-9754706", "R-MMU-9754706", "R-MMU-9758890", "R-CFA-2142691", "R-HSA-9749641", "R-MMU-2142691", "R-DDI-189483", "R-SCE-9758890", "R-DDI-9758890", "R-CFA-1660661", "R-BTA-9707564", "R-SPO-382556", "R-DDI-382556", "R-DDI-9749641", "R-DDI-9748787", "R-CFA-9753281", "R-BTA-382556", "R-BTA-9758890", "R-SCE-1660661", "R-CFA-189483", "R-DDI-9754706", "R-SCE-159418", "R-HSA-189483", "R-CFA-9758890", "R-RNO-159418", "R-RNO-9754706", "R-BTA-189483", "R-DDI-2142691", "R-SPO-9753281", "R-SCE-9753281", "R-SPO-9749641", "R-SPO-9707564", "R-SCE-9749641", "R-MMU-382556", "R-SPO-159418", "R-HSA-5690338", "R-HSA-382556", "R-RNO-9707564", "R-HSA-9753281", "R-HSA-1660661", "R-HSA-9758890", "R-BTA-1660661", "R-DDI-159418", "R-RNO-2142691", "R-HSA-9818032", "R-RNO-9749641", "R-RNO-1660661", "R-HSA-159418", "R-SPO-1660661", "R-SCE-189483", "R-DDI-9753281", "R-BTA-9753281", "R-MMU-159418", "R-MMU-9707564", "R-DDI-9707564", "R-MMU-1660661"], "pathways": ["PWY-8259:t:arsenic detoxification (plants)", "PWY-8301:t:S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis", "PWY-4061:t:glutathione-mediated detoxification I", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-4621:t:arsenic detoxification (bacteria)", "R-HSA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SCE-382556:r:ABC-family proteins mediated transport", "R-MMU-9753281:r:Paracetamol ADME", "R-SPO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DDI-2142845:r:Hyaluronan metabolism", "R-RNO-9753281:r:Paracetamol ADME", "R-DDI-1660661:r:Sphingolipid de novo biosynthesis", "R-RNO-382556:r:ABC-family proteins mediated transport", "R-SCE-9754706:r:Atorvastatin ADME", "R-SCE-9707564:r:Cytoprotection by HMOX1", "R-MMU-189483:r:Heme degradation", "R-RNO-9758890:r:Transport of RCbl within the body", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-SCE-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-189483:r:Heme degradation", "R-MMU-9749641:r:Aspirin ADME", "R-RNO-189483:r:Heme degradation", "R-CFA-9707564:r:Cytoprotection by HMOX1", "R-SPO-9754706:r:Atorvastatin ADME", "R-HSA-5679001:r:Defective ABCC2 causes DJS", "R-BTA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-CFA-382556:r:ABC-family proteins mediated transport", "R-SPO-9758890:r:Transport of RCbl within the body", "R-HSA-9754706:r:Atorvastatin ADME", "R-MMU-9754706:r:Atorvastatin ADME", "R-MMU-9758890:r:Transport of RCbl within the body", "R-CFA-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9749641:r:Aspirin ADME", "R-MMU-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-DDI-189483:r:Heme degradation", "R-SCE-9758890:r:Transport of RCbl within the body", "R-DDI-9758890:r:Transport of RCbl within the body", "R-CFA-1660661:r:Sphingolipid de novo biosynthesis", "R-BTA-9707564:r:Cytoprotection by HMOX1", "R-SPO-382556:r:ABC-family proteins mediated transport", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-DDI-9749641:r:Aspirin ADME", "R-DDI-9748787:r:Azathioprine ADME", "R-CFA-9753281:r:Paracetamol ADME", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-BTA-9758890:r:Transport of RCbl within the body", "R-SCE-1660661:r:Sphingolipid de novo biosynthesis", "R-CFA-189483:r:Heme degradation", "R-DDI-9754706:r:Atorvastatin ADME", "R-SCE-159418:r:Recycling of bile acids and salts", "R-HSA-189483:r:Heme degradation", "R-CFA-9758890:r:Transport of RCbl within the body", "R-RNO-159418:r:Recycling of bile acids and salts", "R-RNO-9754706:r:Atorvastatin ADME", "R-BTA-189483:r:Heme degradation", "R-DDI-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-SPO-9753281:r:Paracetamol ADME", "R-SCE-9753281:r:Paracetamol ADME", "R-SPO-9749641:r:Aspirin ADME", "R-SPO-9707564:r:Cytoprotection by HMOX1", "R-SCE-9749641:r:Aspirin ADME", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-SPO-159418:r:Recycling of bile acids and salts", "R-HSA-5690338:r:Defective ABCC6 causes PXE", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-HSA-9753281:r:Paracetamol ADME", "R-HSA-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-9758890:r:Transport of RCbl within the body", "R-BTA-1660661:r:Sphingolipid de novo biosynthesis", "R-DDI-159418:r:Recycling of bile acids and salts", "R-RNO-2142691:r:Synthesis of Leukotrienes (LT) and Eoxins (EX)", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-RNO-9749641:r:Aspirin ADME", "R-RNO-1660661:r:Sphingolipid de novo biosynthesis", "R-HSA-159418:r:Recycling of bile acids and salts", "R-SPO-1660661:r:Sphingolipid de novo biosynthesis", "R-SCE-189483:r:Heme degradation", "R-DDI-9753281:r:Paracetamol ADME", "R-BTA-9753281:r:Paracetamol ADME", "R-MMU-159418:r:Recycling of bile acids and salts", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-DDI-9707564:r:Cytoprotection by HMOX1", "R-MMU-1660661:r:Sphingolipid de novo biosynthesis"], "type": "Domain"}, "IPR056228": {"description": "ABCC10-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ABCC10-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056229": {"description": "TMEM62, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TMM62", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056230": {"description": "TMEM62, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TMEM62_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056231": {"description": "VNG_1110C-like", "go_ids": [], "go_terms": [], "name": "VNG_1110C-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056232": {"description": "Nuclear pore complex protein GP210, Ig-like domain 15", "go_ids": [], "go_terms": [], "name": "Ig_GP210_15th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056233": {"description": "Nuclear pore complex protein GP210, C-terminal Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_GP210_16th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056234": {"description": "NFXL1, RRM-like domain", "go_ids": [], "go_terms": [], "name": "RRM_NFXL1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056235": {"description": "INTS4, 8 helical bundle domain", "go_ids": [], "go_terms": [], "name": "INTS4_8HBD", "pathway_ids": ["R-DME-6807505", "R-MMU-6807505", "R-HSA-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR056236": {"description": "PCA1, HMA heavy metal-associated domain", "go_ids": [], "go_terms": [], "name": "HMA_PCA1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056237": {"description": "ANKLE2, third alpha/beta domain", "go_ids": [], "go_terms": [], "name": "ANKLE2_3rd", "pathway_ids": ["R-RNO-2995383", "R-DME-2995383", "R-CEL-2995383", "R-MMU-9013408", "R-RNO-9013404", "R-RNO-9013408", "R-HSA-2995383", "R-HSA-9013408", "R-MMU-9013404", "R-MMU-2995383", "R-HSA-9013404"], "pathways": ["R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-CEL-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-9013404:r:RAC2 GTPase cycle"], "type": "Domain"}, "IPR056238": {"description": "YunG-like", "go_ids": [], "go_terms": [], "name": "YunG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056239": {"description": "Phage YunG-like", "go_ids": [], "go_terms": [], "name": "Phage_YunG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056240": {"description": "POF1B, helix-loop-helix domain", "go_ids": [], "go_terms": [], "name": "POF1B_HlH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056241": {"description": "E3 ubiquitin-protein ligase listerin, HEAT-repeats region", "go_ids": [], "go_terms": [], "name": "LTN1_HEAT_5th", "pathway_ids": ["PWY-7511", "R-MMU-9954709", "R-HSA-983168", "R-CEL-983168", "R-CEL-9954709", "R-HSA-9954709", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR056242": {"description": "TASOR, PIN domain", "go_ids": [], "go_terms": [], "name": "PIN_TASOR", "pathway_ids": ["R-HSA-9843970"], "pathways": ["R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "type": "Domain"}, "IPR056243": {"description": "TASOR, alpha/beta domain", "go_ids": [], "go_terms": [], "name": "TASOR_ab_dom", "pathway_ids": ["R-HSA-9843970"], "pathways": ["R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "type": "Domain"}, "IPR056244": {"description": "DEAH11/12, RRM domain", "go_ids": [], "go_terms": [], "name": "RRM_DEAH11/12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056245": {"description": "DEAH11/12, KH-domain", "go_ids": [], "go_terms": [], "name": "KH_DEAH11/12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056246": {"description": "DEAH11/12, type I KH-domain", "go_ids": [], "go_terms": [], "name": "KH_DEAH11/12_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056247": {"description": "DEAH11/12, second type I KH-domain", "go_ids": [], "go_terms": [], "name": "KH_DEAH11/12_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056248": {"description": "DEAH11/12, RNA-binding domain", "go_ids": [], "go_terms": [], "name": "RBD_DEAH11/12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056250": {"description": "Bacterial primase 1D-like", "go_ids": [], "go_terms": [], "name": "Primase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056251": {"description": "Arm-like repeat domain", "go_ids": [], "go_terms": [], "name": "Arm_rpt_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056252": {"description": "Alfy-like, armadillo-like repeat domain", "go_ids": [], "go_terms": [], "name": "Alfy-like_Arm-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056253": {"description": "At2g29880-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "At2g29880-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056254": {"description": "At5g58720/SDE5-like, UBA-like domain", "go_ids": [], "go_terms": [], "name": "At5g58720/SDE5-like_UBA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056255": {"description": "Cartilage intermediate layer protein 1/2 domain", "go_ids": [], "go_terms": [], "name": "CILP-1/2_dom", "pathway_ids": ["R-MMU-2404192", "R-HSA-2404192"], "pathways": ["R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "type": "Domain"}, "IPR056256": {"description": "Cartilage intermediate layer protein 1/2, beta-sandwich domain 2", "go_ids": [], "go_terms": [], "name": "CILP-1/2_b-sand_dom2", "pathway_ids": ["R-MMU-2404192", "R-HSA-2404192"], "pathways": ["R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "type": "Domain"}, "IPR056257": {"description": "Cartilage intermediate layer protein 1/2, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "CILP-1/2_8th", "pathway_ids": ["R-MMU-2404192", "R-HSA-2404192"], "pathways": ["R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "type": "Domain"}, "IPR056258": {"description": "Cartilage intermediate layer protein 1/2, C-terminal", "go_ids": [], "go_terms": [], "name": "CILP-1/2_C", "pathway_ids": ["R-MMU-2404192", "R-HSA-2404192"], "pathways": ["R-MMU-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-2404192:r:Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "type": "Domain"}, "IPR056259": {"description": "Caspase-8, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Dredd_N", "pathway_ids": ["R-DME-198323", "R-DME-214411", "R-DME-111458", "R-DME-214397", "R-DME-9627069", "R-DME-6803207", "R-DME-214399", "R-DME-214416", "R-DME-111459", "R-DME-9948011", "R-DME-9948001"], "pathways": ["R-DME-198323:r:AKT phosphorylates targets in the cytosol", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-111458:r:Formation of apoptosome", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-9948011:r:CASP5 inflammasome assembly", "R-DME-9948001:r:CASP4 inflammasome assembly"], "type": "Domain"}, "IPR056260": {"description": "Caspase-8, second domain", "go_ids": [], "go_terms": [], "name": "Dredd_2nd", "pathway_ids": ["R-DME-198323", "R-DME-214411", "R-DME-111458", "R-DME-214397", "R-DME-9627069", "R-DME-6803207", "R-DME-214399", "R-DME-214416", "R-DME-111459", "R-DME-9948011", "R-DME-9948001"], "pathways": ["R-DME-198323:r:AKT phosphorylates targets in the cytosol", "R-DME-214411:r:REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-111458:r:Formation of apoptosome", "R-DME-214397:r:Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-9627069:r:Regulation of the apoptosome activity", "R-DME-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DME-214399:r:Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'", "R-DME-214416:r:Phosphorylated REL is cleaved by and dissociates from DREDD", "R-DME-111459:r:Activation of caspases through apoptosome-mediated cleavage", "R-DME-9948011:r:CASP5 inflammasome assembly", "R-DME-9948001:r:CASP4 inflammasome assembly"], "type": "Domain"}, "IPR056261": {"description": "1,3-beta-glucan synthase component FKS1-like, domain-2", "go_ids": [], "go_terms": [], "name": "FKS1-like_dom2", "pathway_ids": ["PWY-6773"], "pathways": ["PWY-6773:t:1,3-beta-D-glucan biosynthesis"], "type": "Domain"}, "IPR056262": {"description": "16S rRNA (adenine(1408)-N(1))-methyltransferase", "go_ids": [], "go_terms": [], "name": "NpmA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056263": {"description": "26S proteasome regulatory subunit RPN11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RPN11_C", "pathway_ids": ["R-MMU-450408", "R-HSA-174178", "R-HSA-9020702", "R-HSA-9604323", "R-MMU-8941858", "R-CEL-5632684", "R-HSA-8951664", "R-HSA-5689880", "R-HSA-9010553", "R-MMU-174154", "R-MMU-69017", "R-HSA-75815", "R-MMU-9020702", "R-CEL-195253", "R-CEL-8941858", "R-DME-5658442", "R-MMU-8948751", "R-DME-8948751", "R-MMU-69481", "R-SPO-5689880", "R-MMU-5689880", "R-MMU-75815", "R-CEL-1234176", "R-DDI-9929491", "R-MMU-5668541", "R-DDI-5689901", "R-DME-5676590", "R-HSA-8854050", "R-DME-2467813", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-HSA-1234176", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-MMU-68867", "R-DDI-174084", "R-DME-4641257", "R-DME-432524", "R-MMU-9932298", "R-DME-209461", "R-MMU-1234176", "R-MMU-4641258", "R-DME-75815", "R-DDI-4641258", "R-HSA-180534", "R-DME-69601", "R-HSA-1236974", "R-DME-1234176", "R-CEL-4608870", "R-CEL-8948751", "R-MMU-5687128", "R-MMU-9766229", "R-DME-5358346", "R-HSA-174154", "R-DDI-187577", "R-DME-69017", "R-DME-983168", "R-HSA-68949", "R-HSA-5610785", "R-MMU-187577", "R-DDI-382556", "R-HSA-2467813", "R-DME-5689901", "R-DME-202424", "R-DME-187577", "R-MMU-8852276", "R-SCE-6798695", "R-MMU-68949", "R-CEL-9907900", "R-HSA-9824272", "R-MMU-174178", "R-CEL-983168", "R-DDI-174178", "R-MMU-349425", "R-MMU-8939236", "R-CEL-8854050", "R-HSA-9907900", "R-DME-350562", "R-DME-174084", "R-DME-9907900", "R-DDI-5689603", "R-CEL-75815", "R-DDI-69601", "R-DDI-2467813", "R-DME-9929491", "R-MMU-9762114", "R-HSA-9762114", "R-MMU-195253", "R-DDI-5689880", "R-MMU-202424", "R-HSA-195253", "R-MMU-382556", "R-HSA-5610780", "R-DME-209360", "R-DDI-5687128", "R-CEL-9755511", "R-DME-6798695", "R-DDI-9907900", "R-SCE-1236978", "R-DME-8939236", "R-MMU-1169091", "R-DME-174184", "R-DME-432626", "R-MMU-5607761", "R-MMU-5676590", "R-DME-8854050", "R-HSA-8939902", "R-CEL-5689880", "R-MMU-174184", "R-MMU-8939902", "R-DME-174178", "R-DME-9932298", "R-DME-9020702", "R-CEL-9762114", "R-HSA-8939236", "R-CEL-8951664", "R-HSA-5358346", "R-SPO-350562", "R-DDI-8854050", "R-HSA-6798695", "R-DME-5689880", "R-MMU-5632684", "R-MMU-5607764", "R-SPO-9907900", "R-MMU-2467813", "R-CEL-6798695", "R-HSA-9932298", "R-MMU-5689901", "R-DME-8951664", "R-HSA-9766229", "R-CEL-187577", "R-HSA-5676590", "R-DDI-1236978", "R-DDI-5632684", "R-DDI-8951664", "R-MMU-8951664", "R-DME-8939902", "R-CEL-5689603", "R-CEL-382556", "R-HSA-4641257", "R-MMU-9929491", "R-HSA-174113", "R-MMU-9929356", "R-DME-4608870", "R-SCE-5668541", "R-DDI-174154", "R-HSA-68867", "R-MMU-9907900", "R-DME-174154", "R-HSA-69481", "R-DME-9762114", "R-CEL-4641258", "R-DDI-5658442", "R-HSA-8941858", "R-DDI-8948751", "R-HSA-5678895", "R-HSA-9755511", "R-HSA-4641258", "R-CEL-9929491", "R-SPO-5689603", "R-DME-9755511", "R-DME-1236978", "R-HSA-180585", "R-SPO-1236978", "R-HSA-1169091", "R-CEL-69017", "R-HSA-4608870", "R-HSA-5658442", "R-MMU-2871837", "R-MMU-4641257", "R-MMU-9931269", "R-DDI-68949", "R-DME-5610785", "R-HSA-8948751", "R-MMU-6798695", "R-HSA-5689603", "R-DME-5607764", "R-DME-209406", "R-DME-2871837", "R-DME-450408", "R-CEL-5689901", "R-DME-8941858", "R-HSA-5689901", "R-MMU-5610780", "R-HSA-187577", "R-SPO-6798695", "R-DME-9954709", "R-DME-1169091", "R-DDI-9755511", "R-DME-382556", "R-HSA-349425", "R-DME-5610780", "R-DME-4641258", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-174184", "R-MMU-350562", "R-MMU-9954709", "R-DDI-75815", "R-MMU-69601", "R-DME-195253", "R-HSA-2871837", "R-MMU-5610785", "R-HSA-9954709", "R-MMU-5358346", "R-HSA-5362768", "R-MMU-8854050", "R-DDI-9954709", "R-DME-5607761", "R-MMU-5658442", "R-MMU-5689603", "R-DME-5689603", "R-HSA-174084", "R-DME-216167", "R-MMU-4608870", "R-HSA-5607764", "R-DME-68949", "R-DDI-69017", "R-CEL-1236978", "R-CEL-9954709", "R-HSA-382556", "R-HSA-8852276", "R-HSA-1236978", "R-HSA-69601", "R-HSA-983168", "R-HSA-5632684", "R-DME-538864", "R-SCE-9907900", "R-HSA-5668541", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-HSA-5687128", "R-DDI-349425", "R-DME-5632684", "R-HSA-69017", "R-DME-432395", "R-MMU-983168", "R-DDI-450408", "R-MMU-1236978", "R-CEL-350562", "R-HSA-350562", "R-HSA-202424", "R-CEL-4641257", "R-DME-68867"], "pathways": ["R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-9020702:r:Interleukin-1 signaling", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-5689901:r:Metalloprotease DUBs", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-2467813:r:Separation of Sister Chromatids", "R-HSA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-4641258:r:Degradation of DVL", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9766229:r:Degradation of CDH1", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-5689901:r:Metalloprotease DUBs", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-9907900:r:Proteasome assembly", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-9907900:r:Proteasome assembly", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-432626:r:Circadian Clock pathway", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-DME-9020702:r:Interleukin-1 signaling", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-8951664:r:Neddylation", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-DDI-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-5689880:r:Ub-specific processing proteases", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-SPO-9907900:r:Proteasome assembly", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-6798695:r:Neutrophil degranulation", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-MMU-5689901:r:Metalloprotease DUBs", "R-DME-8951664:r:Neddylation", "R-HSA-9766229:r:Degradation of CDH1", "R-CEL-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DDI-5632684:r:Hedgehog 'on' state", "R-DDI-8951664:r:Neddylation", "R-MMU-8951664:r:Neddylation", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-HSA-4641257:r:Degradation of AXIN", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-4641258:r:Degradation of DVL", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-5689603:r:UCH proteinases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5689603:r:UCH proteinases", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-CEL-5689901:r:Metalloprotease DUBs", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-HSA-5689901:r:Metalloprotease DUBs", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-SPO-6798695:r:Neutrophil degranulation", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-4641258:r:Degradation of DVL", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-5689603:r:UCH proteinases", "R-DME-5689603:r:UCH proteinases", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-216167:r:Nuclear CI is degraded", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-68949:r:Orc1 removal from chromatin", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-68949:r:Orc1 removal from chromatin", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-432395:r:Degradation of TIM", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-CEL-4641257:r:Degradation of AXIN", "R-DME-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR056264": {"description": "ABCA1-4-like, C-terminal R2 regulatory domain", "go_ids": [], "go_terms": [], "name": "R2_ABCA1-4-like", "pathway_ids": ["R-HSA-1989781", "R-HSA-6798695", "R-DDI-382556", "R-BTA-382556", "R-HSA-9918454", "R-MMU-1369062", "R-HSA-1369062", "R-HSA-9615017", "R-HSA-5683678", "R-HSA-9029569", "R-MMU-9029569", "R-MMU-5683826", "R-MMU-382556", "R-DDI-1369062", "R-DDI-6798695", "R-HSA-8963896", "R-DDI-5683826", "R-HSA-5682294", "R-HSA-382556", "R-MMU-2453902", "R-RNO-5683826", "R-DDI-8963896", "R-HSA-5682113", "R-MMU-8963896", "R-HSA-5683826", "R-HSA-5688399", "R-RNO-1369062", "R-MMU-6798695", "R-BTA-2453902", "R-DDI-2453902", "R-HSA-2453902"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-HSA-9918454:r:Defective visual phototransduction due to ABCA4 loss of function", "R-MMU-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-1369062:r:ABC transporters in lipid homeostasis", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-5683678:r:Defective ABCA3 causes SMDP3", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-MMU-5683826:r:Surfactant metabolism", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-DDI-1369062:r:ABC transporters in lipid homeostasis", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-8963896:r:HDL assembly", "R-DDI-5683826:r:Surfactant metabolism", "R-HSA-5682294:r:Defective ABCA12 causes ARCI4B", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-MMU-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-RNO-5683826:r:Surfactant metabolism", "R-DDI-8963896:r:HDL assembly", "R-HSA-5682113:r:Defective ABCA1 causes TGD", "R-MMU-8963896:r:HDL assembly", "R-HSA-5683826:r:Surfactant metabolism", "R-HSA-5688399:r:Defective ABCA3 causes SMDP3", "R-RNO-1369062:r:ABC transporters in lipid homeostasis", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-DDI-2453902:r:The canonical retinoid cycle in rods (twilight vision)", "R-HSA-2453902:r:The canonical retinoid cycle in rods (twilight vision)"], "type": "Domain"}, "IPR056265": {"description": "CD1375-like domain", "go_ids": [], "go_terms": [], "name": "CD1375-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056266": {"description": "CDCP1, third and sixth CUB domain", "go_ids": [], "go_terms": [], "name": "CDCP1_CUB_3rd_6th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056267": {"description": "Ada2b, tri-helical domain", "go_ids": [], "go_terms": [], "name": "Ada2b_C", "pathway_ids": ["R-DME-5689880", "R-HSA-3214847", "R-DRE-5689880", "R-HSA-5689880"], "pathways": ["R-DME-5689880:r:Ub-specific processing proteases", "R-HSA-3214847:r:HATs acetylate histones", "R-DRE-5689880:r:Ub-specific processing proteases", "R-HSA-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR056268": {"description": "CDCP1, first CUB domain", "go_ids": [], "go_terms": [], "name": "CUB_CDCP1_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056269": {"description": "CDCP1, second and fifth CUB domain", "go_ids": [], "go_terms": [], "name": "CUB_CDCP1_2nd_5th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056270": {"description": "A disintegrin and metalloproteinase with thrombospondin motifs 17/19, C-terminal helical domain", "go_ids": [], "go_terms": [], "name": "ADAMTS17/19_C", "pathway_ids": ["PWY-8119", "R-HSA-5083635", "R-MMU-5173214", "R-HSA-5173214"], "pathways": ["PWY-8119:t:microcin B17 biosynthesis", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Domain"}, "IPR056271": {"description": "CDGP domain", "go_ids": [], "go_terms": [], "name": "CDGP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056272": {"description": "ADAMTS-like protein 1 domain", "go_ids": [], "go_terms": [], "name": "ADAMTSL1_dom", "pathway_ids": ["R-HSA-5083635", "R-MMU-5173214", "R-HSA-5173214"], "pathways": ["R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Domain"}, "IPR056273": {"description": "CDK5 regulatory subunit-associated protein 2/Myomegalin, coiled coil", "go_ids": [], "go_terms": [], "name": "CDK5RAP2_MYOME_CC", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-MMU-380270", "R-HSA-380284", "R-HSA-380270", "R-RNO-5620912", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-RNO-380320", "R-RNO-380259", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR056274": {"description": "Adhesion G-protein coupled receptor F3, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_ADGRF3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056275": {"description": "Cdr2, UBA domain", "go_ids": [], "go_terms": [], "name": "UBA_Crd2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056276": {"description": "AtC3H46-like, PABC-like domain", "go_ids": [], "go_terms": [], "name": "AtC3H46-like_PABC-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056277": {"description": "AIP/AIPL, N-terminal FKBP-type PPIase domain", "go_ids": [], "go_terms": [], "name": "PPIase_AIP", "pathway_ids": ["R-HSA-8950505", "R-HSA-8937144"], "pathways": ["R-HSA-8950505:r:Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-8937144:r:Aryl hydrocarbon receptor signalling"], "type": "Domain"}, "IPR056278": {"description": "CdrL-like, middle region", "go_ids": [], "go_terms": [], "name": "CdrL_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056279": {"description": "Aip3p/Bud6, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Aip3p_Bud6_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056280": {"description": "AIPP2-like, SPOC-like domain", "go_ids": [], "go_terms": [], "name": "AIPP2-like_SPOC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056281": {"description": "ATG1a/b/c, MIT domain", "go_ids": [], "go_terms": [], "name": "MIT_ATG1a/b/c", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056282": {"description": "MROH2B-like, N-terminal HEAT-repeats domain", "go_ids": [], "go_terms": [], "name": "MROH2B-like_N_HEAT", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056283": {"description": "CdsD, C-terminal", "go_ids": [], "go_terms": [], "name": "CdsD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056284": {"description": "AIR9-like, A9 domain", "go_ids": [], "go_terms": [], "name": "AIR9-like_A9", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056285": {"description": "CdsD, PD1 domain", "go_ids": [], "go_terms": [], "name": "CdsD_PD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056286": {"description": "CELSR1-3-like, ninth cadherin domain", "go_ids": [], "go_terms": [], "name": "Cadherin_CELSR1-3_9th", "pathway_ids": ["R-DME-350379", "R-DME-350368", "R-DME-350480", "R-DME-350411", "R-DME-450728", "R-DME-350376"], "pathways": ["R-DME-350379:r:Homo-/heterophilic binding of transmembrane components", "R-DME-350368:r:Activation of RHO1 by FZ:DSH complex", "R-DME-350480:r:Activation of non-muscle Myosin II", "R-DME-350411:r:Formation and asymmetric localisation of transmembrane complexes", "R-DME-450728:r:Inhibition of actin polymerization", "R-DME-350376:r:Activation of RAC1:GTP by FZ:DSH complex"], "type": "Domain"}, "IPR056287": {"description": "AIR9, PH-like domain", "go_ids": [], "go_terms": [], "name": "PH_AIR9", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056288": {"description": "Centrosomal protein of 76 kDa, C-terminal", "go_ids": [], "go_terms": [], "name": "CEP76_C", "pathway_ids": ["R-MMU-380259", "R-MMU-380270", "R-DRE-380320", "R-XTR-380270", "R-XTR-380284", "R-HSA-380284", "R-HSA-380270", "R-MMU-380284", "R-XTR-380320", "R-XTR-380259", "R-MMU-2565942", "R-MMU-380320", "R-HSA-8854518", "R-HSA-2565942", "R-HSA-380320", "R-XTR-5620912", "R-XTR-2565942", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-XTR-8854518"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2"], "type": "Domain"}, "IPR056289": {"description": "CEP76, N-terminal", "go_ids": [], "go_terms": [], "name": "CEP76_N", "pathway_ids": ["R-MMU-380259", "R-MMU-380270", "R-DRE-380320", "R-XTR-380270", "R-XTR-380284", "R-HSA-380284", "R-HSA-380270", "R-MMU-380284", "R-XTR-380320", "R-XTR-380259", "R-MMU-2565942", "R-MMU-380320", "R-HSA-8854518", "R-HSA-2565942", "R-HSA-380320", "R-XTR-5620912", "R-XTR-2565942", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-XTR-8854518"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2"], "type": "Domain"}, "IPR056290": {"description": "CEP76/DRC7, peptidase-like domain", "go_ids": [], "go_terms": [], "name": "CEPT76/DRC7_peptidase-like_dom", "pathway_ids": ["R-MMU-380259", "R-MMU-380270", "R-DRE-380320", "R-XTR-380270", "R-XTR-380284", "R-HSA-380284", "R-HSA-380270", "R-MMU-380284", "R-XTR-380320", "R-XTR-380259", "R-MMU-2565942", "R-MMU-380320", "R-HSA-8854518", "R-HSA-2565942", "R-HSA-380320", "R-XTR-5620912", "R-XTR-2565942", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-XTR-8854518"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2"], "type": "Domain"}, "IPR056291": {"description": "Dynein regulatory complex subunit 7, 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"go_terms": [], "name": "Ig-CFAP74_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056309": {"description": "CGL160/ATPI domain", "go_ids": [], "go_terms": [], "name": "CGL160/ATPI_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056310": {"description": "CFAP74, fourth Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig-CFAP74_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056311": {"description": "TMEM131, second Ig-like domain", "go_ids": [], "go_terms": [], "name": "TMEM131_Ig_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056312": {"description": "Antitoxin Xre/MbcA/ParS-like, middle domain", "go_ids": [], "go_terms": [], "name": "Xre-MbcA-ParS_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056313": {"description": "Antitoxin Xre/MbcA/ParS-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Xre_MbcA_ParS-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056314": {"description": "AP-3 complex subunit beta-1/2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AP3B1/2_C", "pathway_ids": ["R-BTA-432722", "R-HSA-6802952", "R-MMU-432722", "R-HSA-432722"], "pathways": ["R-BTA-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-MMU-432722:r:Golgi Associated Vesicle Biogenesis", "R-HSA-432722:r:Golgi Associated Vesicle Biogenesis"], "type": "Domain"}, "IPR056315": {"description": "SmORF-like domain, apicomplexa", "go_ids": [], "go_terms": [], "name": "SmORF-like_dom_apicomplexa", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056316": {"description": "Microprotein, apicomplexa 2", "go_ids": [], "go_terms": [], "name": "Microp_apicomplexa_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056317": {"description": "Microprotein, apicomplexa", "go_ids": [], "go_terms": [], "name": "Microp_apicomplexa", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056318": 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"R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9707616:r:Heme signaling", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-RNO-3769402:r:Deactivation of the beta-catenin transactivating complex", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR056343": {"description": "Cilia- and flagella-associated protein 47 domain", "go_ids": [], "go_terms": [], "name": "CFAP47_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056344": {"description": "CFAP65-like, ninth Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_CFAP65-like_9th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056345": {"description": "CIZ1, C2H2-type zinc finger", 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synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-6782135:r:Dual incision in TC-NER", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DME-6782135:r:Dual incision in TC-NER", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER"], "type": "Domain"}, "IPR056351": {"description": "Microprotein domain, apicomplexa 3", "go_ids": [], "go_terms": [], "name": "Microp_dom_apicomplexa_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056352": {"description": "Microprotein, apicomplexa 13", "go_ids": [], "go_terms": [], "name": "Microp_apicomplexa_13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056353": {"description": "Microprotein domain, apicomplexa 4", "go_ids": [], "go_terms": [], "name": "Microp_dom_apicomplexa_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056354": {"description": "Microprotein domain, apicomplexa 5", "go_ids": [], "go_terms": [], "name": "Microp_dom_apicomplexa_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056355": {"description": "Microprotein, apicomplexa 16", "go_ids": [], "go_terms": [], "name": "Microp_apicomplexa_16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056356": {"description": "Microprotein, apicomplexa 17", "go_ids": [], "go_terms": [], "name": "Microp_apicomplexa_17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056357": {"description": "Apc4, C-terminal half WD40 domain, schizosaccharomycetes", "go_ids": [], "go_terms": [], "name": "Apc4_C_schizosaccharomycetes", "pathway_ids": ["R-SPO-179409", "R-SPO-2559582", "R-SPO-176408", "R-SPO-983168"], "pathways": ["R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR056358": {"description": "Anaphase-promoting complex subunit 4, C-terminal half WD40 domain", "go_ids": [], "go_terms": [], "name": "APC4_C", "pathway_ids": ["R-HSA-8853884", "R-MMU-176408", "R-MMU-176409", "R-MMU-68867", "R-HSA-174178", "R-HSA-176409", "R-HSA-2467813", "R-HSA-9687136", "R-MMU-174154", "R-MMU-2467813", "R-MMU-179409", "R-MMU-69017", "R-MMU-2559582", "R-HSA-983168", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-MMU-176412", "R-MMU-174048", "R-HSA-176408", "R-MMU-176407", "R-HSA-141430", "R-MMU-174184", "R-MMU-141430", "R-HSA-69017", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-174154", "R-HSA-68867", "R-HSA-176412"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C"], "type": "Domain"}, "IPR056359": {"description": "ApeC, platyhelminthes", "go_ids": [], "go_terms": [], "name": "ApeC_platyh", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056360": {"description": "ATPase MORC2, chromo domain-like", "go_ids": [], "go_terms": [], "name": "Chromo_MORC2_6th", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-MMU-75105", "R-HSA-9843970", "R-HSA-75105"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR056361": {"description": "AtPDCT1/2, transmembrane domain", "go_ids": [], "go_terms": [], "name": "AtPDCT1_2_TM_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056362": {"description": "AtuA-like, ferredoxin-fold domain", "go_ids": [], "go_terms": [], "name": "AtuA-like_ferredoxin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056363": {"description": "Leucine-rich repeat and WD repeat-containing protein 1, LRR domain", "go_ids": [], "go_terms": [], "name": "LRR_LRWD1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056364": {"description": "MABP1/WRD62, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "WDR62-MABP1_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056365": {"description": "NAD-specific glutamate dehydrogenase, second domain", "go_ids": [], "go_terms": [], "name": "NAD-GDH_2nd", "pathway_ids": ["PWY-6728", "PWY-5022", "PWY-7126", "PWY-8190"], "pathways": ["PWY-6728:t:methylaspartate cycle", "PWY-5022:t:4-aminobutanoate degradation V", "PWY-7126:t:ethene biosynthesis IV (engineered)", "PWY-8190:t:L-glutamate degradation XI (reductive Stickland reaction)"], "type": "Domain"}, "IPR056366": {"description": "Large ribosomal subunit protein eL24", "go_ids": ["GO:0003735"], "go_terms": ["GO:0003735:structural constituent of ribosome:F"], "name": "Ribosomal_eL24", "pathway_ids": ["R-BTA-975957", "R-CEL-975957", "R-HSA-9010553", "R-SPO-9954714", "R-SCE-9954709", "R-SPO-975957", "R-DRE-9954709", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-BTA-72689", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954716", "R-CEL-9954714", "R-RNO-975957", "R-HSA-1799339", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-SPO-9954709", "R-SPO-975956", "R-RNO-156827", "R-MMU-9954714", "R-BTA-6791226", "R-DRE-9954714", "R-SPO-72706", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-DRE-1799339", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-DDI-72689", "R-MMU-1799339", "R-SPO-72689", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-BTA-72706", "R-SCE-975957", "R-HSA-9954709", "R-DDI-9954716", "R-SPO-1799339", "R-SCE-1799339", "R-DME-1799339", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-DRE-156827", "R-SCE-156827", "R-DRE-975956", "R-DME-975956", "R-BTA-9954716", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-DRE-975957", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-BTA-1799339", "R-BTA-9954714", "R-HSA-975957", "R-DME-9954714", "R-DRE-72689", "R-BTA-975956", "R-DRE-9954716", "R-BTA-9954709", "R-DRE-6791226", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DRE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-2408557:r:Selenocysteine synthesis", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-BTA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-BTA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DRE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-BTA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-DRE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-BTA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-BTA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DRE-72689:r:Formation of a pool of free 40S subunits", "R-BTA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-DRE-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR056370": {"description": "DE-cadherin-like, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Shg-like_Ig-like", "pathway_ids": ["R-DME-6798695", "R-DME-9013423", "R-DME-351906", "R-DME-6809371"], "pathways": ["R-DME-6798695:r:Neutrophil degranulation", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DME-351906:r:Apoptotic cleavage of cell adhesion proteins", "R-DME-6809371:r:Formation of the cornified envelope"], "type": "Domain"}, "IPR056371": {"description": "ATP-dependent RNA helicase DHX37-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DHX37-like_C", "pathway_ids": ["R-DME-6791226", "R-HSA-6791226", "R-CEL-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR056372": {"description": "Dedicator of cytokinesis, TPR repeats region", "go_ids": [], "go_terms": [], "name": "TPR_DOCK", "pathway_ids": ["R-MMU-9013404", "R-MMU-983231", "R-HSA-418885", "R-MMU-4420097", "R-MMU-2029482", "R-HSA-8849471", "R-HSA-9013404", "R-HSA-4420097", "R-HSA-9032759", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013149", "R-MMU-9032759", "R-HSA-164944", "R-MMU-6798695", "R-HSA-9013408", "R-HSA-9664422", "R-MMU-8849471", "R-MMU-418885", "R-HSA-6798695", "R-MMU-8980692", "R-HSA-983231", "R-MMU-9013408", "R-HSA-2029482"], "pathways": ["R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9032759:r:NTRK2 activates RAC1", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-9032759:r:NTRK2 activates RAC1", "R-HSA-164944:r:Nef and signal transduction", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-418885:r:DCC mediated attractive signaling", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation"], "type": "Domain"}, "IPR056373": {"description": "Defensin-like domain", "go_ids": [], "go_terms": [], "name": "Defensin-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056374": {"description": "DesK/YvfT, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DesK/YvfT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056376": {"description": "DEX1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DEX1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056377": {"description": "DExH18, N-terminal", "go_ids": [], "go_terms": [], "name": "DExH18_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056379": {"description": "DExH14, plug domain", "go_ids": [], "go_terms": [], "name": "DExH14_plug", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056380": {"description": "ASCIZ, forth C2H2 zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_ASCIZ_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056381": {"description": "ASCIZ, third C2HC zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_C2HC_ASCIZ_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056382": {"description": "DHX34-like, C2H2-type zinc finger", "go_ids": [], "go_terms": [], "name": "DHX34_Znf-C2H2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056383": {"description": "Diacylglycerol kinase iota-like domain", "go_ids": [], "go_terms": [], "name": "DGKI-like_dom", "pathway_ids": ["PWY-7039", "PWY-7817", "R-MMU-114508", "R-RNO-114508", "R-HSA-114508", "R-DME-114508", "R-CEL-114508"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-114508:r:Effects of PIP2 hydrolysis", "R-DME-114508:r:Effects of PIP2 hydrolysis", "R-CEL-114508:r:Effects of PIP2 hydrolysis"], "type": "Domain"}, "IPR056384": {"description": "At3g06530-like, ARM-repeats domain", "go_ids": [], "go_terms": [], "name": "ARM_At3g06530", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056385": {"description": "AVO1/Sin1, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "UBL_AVO1/Sin1", "pathway_ids": ["R-SCE-6804757", "R-SPO-6804757", "R-SCE-1257604", "R-SPO-389357", "R-SPO-5218920", "R-SPO-9856530", "R-SCE-389357", "R-SPO-1257604", "R-SCE-9856530", "R-SCE-5218920"], "pathways": ["R-SCE-6804757:r:Regulation of TP53 Degradation", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-SPO-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-5218920:r:VEGFR2 mediated vascular permeability", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-389357:r:CD28 dependent PI3K/Akt signaling", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SCE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability"], "type": "Domain"}, "IPR056386": {"description": "B-cell receptor CD22, first Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_CD22", "pathway_ids": ["R-HSA-198933", "R-MMU-198933", "R-HSA-5690714", "R-MMU-983695", "R-HSA-983695", "R-MMU-5690714"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-5690714:r:CD22 mediated BCR regulation", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-5690714:r:CD22 mediated BCR regulation"], "type": "Domain"}, "IPR056387": {"description": "Bacterial deaminase MsddA-like domain", "go_ids": [], "go_terms": [], "name": "MsddA-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056388": {"description": "YxkI, PH domain", "go_ids": [], "go_terms": [], "name": "PH_YxkI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056389": {"description": "Baseplate tube protein p140", "go_ids": [], "go_terms": [], "name": "Baseplate_tube_p140", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056390": {"description": "Holin, bacteriophage", "go_ids": [], "go_terms": [], "name": "Holin_phage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056391": {"description": "Baseplate protein gp9-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Baseplate_gp9_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056392": {"description": "Diacylglycerol kinase theta, RNA-binding domain", "go_ids": [], "go_terms": [], "name": "DGKtheta_RBD", "pathway_ids": ["PWY-7039", "PWY-7817", "R-MMU-114508", "R-RNO-114508", "R-HSA-114508"], "pathways": ["PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "R-MMU-114508:r:Effects of PIP2 hydrolysis", "R-RNO-114508:r:Effects of PIP2 hydrolysis", "R-HSA-114508:r:Effects of PIP2 hydrolysis"], "type": "Domain"}, "IPR056393": {"description": "AprA-like, MT2-like domain", "go_ids": [], "go_terms": [], "name": "AprA-like_MT2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056394": {"description": "AprA-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AprA-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056395": {"description": "AprA, winged helix domain", "go_ids": [], "go_terms": [], "name": "WH_AprA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056396": {"description": "Cohesin subunit SCC3/SA, HEAT-repeats domain", "go_ids": [], "go_terms": [], "name": "HEAT_SCC3-SA", "pathway_ids": ["R-HSA-2468052", "R-MMU-2500257", "R-SPO-2500257", "R-SPO-3108214", "R-SPO-2470946", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-3108214", "R-MMU-2467813", "R-CEL-2470946", "R-HSA-2470946", "R-HSA-1221632", "R-CEL-3108214", "R-MMU-3108214", "R-CEL-2468052", "R-MMU-2468052", "R-MMU-2470946", "R-HSA-9018519", "R-CEL-2500257"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-SPO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-SPO-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-1221632:r:Meiotic synapsis", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion"], "type": "Domain"}, "IPR056397": {"description": "Fibronectin-III type-like domain, archaea", "go_ids": [], "go_terms": [], "name": "Fn3_arc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056398": {"description": "Coilin, tudor domain", "go_ids": [], "go_terms": [], "name": "Tudor_Coilin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056399": {"description": "Microprotein, archaea", "go_ids": [], "go_terms": [], "name": "Microp_archaea", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056400": {"description": "Cold shock domain-containing protein E1, CSD domain", "go_ids": [], "go_terms": [], "name": "CSDE1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056401": {"description": "Major capsid protein, crassvirus", "go_ids": [], "go_terms": [], "name": "Crass_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056403": {"description": "Ribonuclease II-like, barrel domain", "go_ids": [], "go_terms": [], "name": "RNase_II_barrel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056404": {"description": "Ribonuclease II-like, double HTH domain", "go_ids": [], "go_terms": [], "name": "HTH_RNase_II", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056405": {"description": "CUL7/CUL9, ARM-repeats domain", "go_ids": [], "go_terms": [], "name": "ARM_CUL7_CUL9", "pathway_ids": ["R-HSA-381038", "R-HSA-983168", "R-RNO-983168", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR056406": {"description": "CWZF3/5/7, THD domain", "go_ids": [], "go_terms": [], "name": "THD_CWZF3/5/7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056407": {"description": "CSLinker motif", "go_ids": [], "go_terms": [], "name": "CSLinker", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR056408": {"description": "CT021-like", "go_ids": [], "go_terms": [], "name": "CT021-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056409": {"description": "CYK3, C-terminal Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_CYK3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056410": {"description": "Cyanophage outer membrane protein-like, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "Phage_OMP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056411": {"description": "Cysteinyl-tRNA ligase, anticodon binding domain", "go_ids": [], "go_terms": [], "name": "CysS_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056412": {"description": "Cytochrome c-type biogenesis protein H, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_CycH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056413": {"description": "Cytochrome c-type biogenesis protein H, TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_CcmH_CycH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056414": {"description": "DAAF9, CobW C-like domain", "go_ids": [], "go_terms": [], "name": "DAAF9_CobW_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056415": {"description": "DCDC1, second doublecortin-like domain", "go_ids": [], "go_terms": [], "name": "DCX2_DCDC1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056416": {"description": "DBL homology domain, fungi", "go_ids": [], "go_terms": [], "name": "DH_2_fung", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056418": {"description": "Tail tube terminator protein p142", "go_ids": [], "go_terms": [], "name": "Phage_tail_terminator_p142", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056419": {"description": "Bardet-Biedl syndrome 1 protein, GAE domain", "go_ids": [], "go_terms": [], "name": "GAE_BBS1", "pathway_ids": ["R-CEL-5620922", "R-MMU-5620922", "R-HSA-5620922"], "pathways": ["R-CEL-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-MMU-5620922:r:BBSome-mediated cargo-targeting to cilium", "R-HSA-5620922:r:BBSome-mediated cargo-targeting to cilium"], "type": "Domain"}, "IPR056420": {"description": "Gem-associated protein 5, RBS domain", "go_ids": [], "go_terms": [], "name": "GEMI5_RBS", "pathway_ids": ["R-HSA-9754678", "R-MMU-191859", "R-HSA-191859"], "pathways": ["R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-MMU-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly"], "type": "Domain"}, "IPR056421": {"description": "Gem-associated protein 5, TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_GEMI5", "pathway_ids": ["R-HSA-9754678", "R-MMU-191859", "R-HSA-191859"], "pathways": ["R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-MMU-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly"], "type": "Domain"}, "IPR056422": {"description": "BP74, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BP74_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056423": {"description": "BPM/SPOP, BACK domain", "go_ids": [], "go_terms": [], "name": "BACK_BPM_SPOP", "pathway_ids": ["R-DRE-9929491", "R-BTA-9929491", "R-BTA-5632684", "R-HSA-9929491", "R-MMU-5632684", "R-XTR-5632684", "R-DME-5632684", "R-CEL-5632684", "R-DRE-5632684", "R-MMU-9929491", "R-DME-9929491", "R-XTR-9929491", "R-DME-216167", "R-HSA-5632684", "R-CEL-9929491"], "pathways": ["R-DRE-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-5632684:r:Hedgehog 'on' state", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5632684:r:Hedgehog 'on' state", "R-XTR-5632684:r:Hedgehog 'on' state", "R-DME-5632684:r:Hedgehog 'on' state", "R-CEL-5632684:r:Hedgehog 'on' state", "R-DRE-5632684:r:Hedgehog 'on' state", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-XTR-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-216167:r:Nuclear CI is degraded", "R-HSA-5632684:r:Hedgehog 'on' state", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "type": "Domain"}, "IPR056424": {"description": "Gem-associated protein 5, second beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_GEMI5_2nd", "pathway_ids": ["R-HSA-9754678", "R-MMU-191859", "R-HSA-191859"], "pathways": ["R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-MMU-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly"], "type": "Domain"}, "IPR056425": {"description": "BT_1020-like, N-terminal beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_BT_1020", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056426": {"description": "BTBDG, BTB/POZ domain", "go_ids": [], "go_terms": [], "name": "BTB_BTBDG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056427": {"description": "Gene 1 ring forming protein domain", "go_ids": [], "go_terms": [], "name": "G1RFP_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056428": {"description": "General transcription factor 3C polypeptide 1, winged-helix domain", "go_ids": [], "go_terms": [], "name": "WH_GTF3C1", "pathway_ids": ["R-MMU-76061", "R-RNO-76061", "R-MMU-76066", "R-HSA-749476", "R-RNO-76066", "R-HSA-76066", "R-HSA-76061"], "pathways": ["R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR056429": {"description": "C-Maf-inducing protein, PH domain", "go_ids": [], "go_terms": [], "name": "PH_CMIP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056430": {"description": "C2 domain-containing protein 5, forth YbjQ-like domain", "go_ids": [], "go_terms": [], "name": "C2CD5_YbjQ-like_dom", "pathway_ids": ["R-HSA-1445148"], "pathways": ["R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "type": "Domain"}, "IPR056431": {"description": "C2 domain-containing protein 5, YbjQ-like domain", "go_ids": [], "go_terms": [], "name": "C2CD5_YbjQ-rel_dom", "pathway_ids": ["R-HSA-1445148"], "pathways": ["R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "type": "Domain"}, "IPR056432": {"description": "Gem-associated protein 5, first beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_GEMI5_1st", "pathway_ids": ["R-HSA-9754678", "R-MMU-191859", "R-HSA-191859"], "pathways": ["R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-MMU-191859:r:snRNP Assembly", "R-HSA-191859:r:snRNP Assembly"], "type": "Domain"}, "IPR056433": {"description": "DmsR-like, N-terminal", "go_ids": [], "go_terms": [], "name": "DmsR-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056434": {"description": "GEX2, N-terminal Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_GEX2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056435": {"description": "DNA polymerase delta/zeta catalytic subunit, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DPOD/Z_N", "pathway_ids": ["R-DDI-6782135", "R-RNO-174437", "R-HSA-5685942", "R-MMU-6782135", "R-HSA-174414", "R-SPO-5656121", "R-SPO-5655862", "R-HSA-5696397", "R-HSA-5358606", "R-MMU-174417", "R-MMU-110312", "R-DDI-6782210", "R-DME-5656121", "R-RNO-110314", "R-SPO-110312", "R-HSA-5655862", "R-RNO-69183", "R-MMU-110314", "R-HSA-174417", "R-RNO-69166", "R-HSA-174437", "R-MMU-174414", "R-RNO-5696397", "R-DME-5655862", "R-DME-110312", "R-DME-69183", "R-MMU-174437", "R-HSA-6782210", "R-RNO-5656169", "R-HSA-5656121", "R-HSA-5656169", "R-MMU-5358606", "R-RNO-174411", "R-MMU-5696400", "R-MMU-5358565", "R-RNO-6782210", "R-MMU-5655862", "R-RNO-5358606", "R-HSA-2564830", "R-RNO-5358565", "R-SCE-69183", "R-DDI-69091", "R-MMU-5651801", "R-RNO-6782135", "R-DDI-69183", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-110312", "R-HSA-5651801", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-DDI-69166", "R-RNO-69091", "R-RNO-5685942", "R-MMU-5656121", "R-SCE-69166", "R-HSA-69183", "R-MMU-69166", "R-RNO-5696400", "R-RNO-174417", "R-HSA-5696400", "R-HSA-5358565", "R-HSA-69091", "R-MMU-6782210", "R-HSA-110314", "R-SCE-110312", "R-MMU-174411", "R-MMU-5696397", "R-RNO-5651801", "R-MMU-69091", "R-DME-69166", "R-RNO-174414"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-RNO-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-174414:r:Processive synthesis on the C-strand of the telomere", "R-SPO-5656121:r:Translesion synthesis by POLI", "R-SPO-5655862:r:Translesion synthesis by POLK", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-MMU-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-MMU-110312:r:Translesion synthesis by REV1", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-5656121:r:Translesion synthesis by POLI", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-110312:r:Translesion synthesis by REV1", "R-HSA-5655862:r:Translesion synthesis by POLK", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-HSA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-MMU-174414:r:Processive synthesis on the C-strand of the telomere", "R-RNO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-110312:r:Translesion synthesis by REV1", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-MMU-174437:r:Removal of the Flap Intermediate from the C-strand", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-MMU-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-5655862:r:Translesion synthesis by POLK", "R-RNO-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-RNO-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-DDI-69091:r:Polymerase switching", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-RNO-6782135:r:Dual incision in TC-NER", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-110312:r:Translesion synthesis by REV1", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-DDI-69166:r:Removal of the Flap Intermediate", "R-RNO-69091:r:Polymerase switching", "R-RNO-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-RNO-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-69091:r:Polymerase switching", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SCE-110312:r:Translesion synthesis by REV1", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-RNO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate", "R-RNO-174414:r:Processive synthesis on the C-strand of the telomere"], "type": "Domain"}, "IPR056436": {"description": "ZIC1-5/GLI1-3like, C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_ZIC1-5/GLI1-3-like", "pathway_ids": ["R-DME-209190", "R-HSA-5610780", "R-MMU-5610780", "R-HSA-5610785", "R-DME-209360", "R-MMU-5632684", "R-MMU-212436", "R-DME-216217", "R-DME-5610780", "R-HSA-452723", "R-HSA-5632684", "R-DME-209338", "R-HSA-9823739", "R-HSA-5635851", "R-DME-209214", "R-DME-209446", "R-HSA-9834899", "R-DME-5632684", "R-MMU-5610785", "R-HSA-5610787", "R-DME-209159", "R-MMU-5610787", "R-DME-5610785", "R-DME-216167", "R-HSA-9856649", "R-DME-5610787", "R-HSA-2892247", "R-HSA-5610783", "R-DME-216119", "R-HSA-212436", "R-HSA-8940973", "R-HSA-8941284"], "pathways": ["R-DME-209190:r:Phosphorylation of CI", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-MMU-5632684:r:Hedgehog 'on' state", "R-MMU-212436:r:Generic Transcription Pathway", "R-DME-216217:r:Activation of SMO", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-452723:r:Transcriptional regulation of pluripotent stem cells", "R-HSA-5632684:r:Hedgehog 'on' state", "R-DME-209338:r:Assembly of the 'signalling complexes'", "R-HSA-9823739:r:Formation of the anterior neural plate", "R-HSA-5635851:r:GLI proteins bind promoters of Hh responsive genes to promote transcription", "R-DME-209214:r:Phosphorylation of SMO", "R-DME-209446:r:N-HH ligand not bound to PTC receptor complex", "R-HSA-9834899:r:Specification of the neural plate border", "R-DME-5632684:r:Hedgehog 'on' state", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-5610787:r:Hedgehog 'off' state", "R-DME-209159:r:Assembly of the CI containing complexes", "R-MMU-5610787:r:Hedgehog 'off' state", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-DME-216167:r:Nuclear CI is degraded", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-DME-5610787:r:Hedgehog 'off' state", "R-HSA-2892247:r:POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-DME-216119:r:Activation of CI", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-8940973:r:RUNX2 regulates osteoblast differentiation", "R-HSA-8941284:r:RUNX2 regulates chondrocyte maturation"], "type": "Domain"}, "IPR056437": {"description": "ZNF598/HEL2, C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_ZNF598/HEL2", "pathway_ids": ["PWY-7511", "R-MMU-9954716", "R-HSA-9954716"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "type": "Domain"}, "IPR056438": {"description": "CTCF-like, C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_CTCF", "pathway_ids": ["R-MMU-9933946", "R-MMU-9934037", "R-HSA-9700645", "R-HSA-9934037", "R-HSA-9933946", "R-HSA-9725370", "R-HSA-5617472"], "pathways": ["R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9700645:r:ALK mutants bind TKIs", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "type": "Domain"}, "IPR056439": {"description": "Scaffold protein spa2, VBS-like domain", "go_ids": [], "go_terms": [], "name": "VBS_Spa2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056440": {"description": "GIR1-like, zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Zn-ribbon_GIR1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056441": {"description": "GLAA-B, beta-barrel domain II", "go_ids": [], "go_terms": [], "name": "Beta-barrel_GLAA-B_II", "pathway_ids": ["PWY-6527"], "pathways": ["PWY-6527:t:stachyose degradation"], "type": "Domain"}, "IPR056442": {"description": "Glucosamine inositolphosphorylceramide transferase 1, N-terminal", "go_ids": [], "go_terms": [], "name": "GINT1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056443": {"description": "C962R-like, N-terminal AEP domain", "go_ids": [], "go_terms": [], "name": "AEP_C962R", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR056444": {"description": "GRF-like, zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_GRF_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056445": {"description": "HPS5, TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_HPS5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056446": {"description": "HPS5, TPR domain, insects", "go_ids": [], "go_terms": [], "name": "TPR_HPS5_insects", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056447": {"description": "DNA polymerase zeta catalytic subunit, N-terminal", "go_ids": [], "go_terms": [], "name": "REV3_N", "pathway_ids": ["R-MMU-5655862", "R-MMU-5656121", "R-DME-5655862", "R-DME-110312", "R-HSA-110312", "R-MMU-110312", "R-DME-5656121", "R-SCE-110312", "R-HSA-5656121", "R-HSA-5655862"], "pathways": ["R-MMU-5655862:r:Translesion synthesis by POLK", "R-MMU-5656121:r:Translesion synthesis by POLI", "R-DME-5655862:r:Translesion synthesis by POLK", "R-DME-110312:r:Translesion synthesis by REV1", "R-HSA-110312:r:Translesion synthesis by REV1", "R-MMU-110312:r:Translesion synthesis by REV1", "R-DME-5656121:r:Translesion synthesis by POLI", "R-SCE-110312:r:Translesion synthesis by REV1", "R-HSA-5656121:r:Translesion synthesis by POLI", "R-HSA-5655862:r:Translesion synthesis by POLK"], "type": "Domain"}, "IPR056448": {"description": "Cadherin-related hmr-1, EGF domain", "go_ids": [], "go_terms": [], "name": "EGF_Hmr-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056449": {"description": "Capsid protein Vp20", "go_ids": [], "go_terms": [], "name": "Vp20_capsid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056450": {"description": "DNA repair protein RAD5A, UBA domain", "go_ids": [], "go_terms": [], "name": "UBA_RAD5A", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056451": {"description": "DNA repair protein rhp7, treble clef domain", "go_ids": [], "go_terms": [], "name": "Znf_Tbcl_Rhp7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056452": {"description": "DNA topoisomerase 3-beta, zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_TOP3B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056453": {"description": "DNAJC9, HTH domain", "go_ids": [], "go_terms": [], "name": "HTH_DNAJC9", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056454": {"description": "IP5PC-F, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_IP5PC_F", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056455": {"description": "IP5PC-F, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig-like_IP5PC_F", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056456": {"description": "IFT80, second beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_IFT80_2nd", "pathway_ids": ["R-MMU-5620924", "R-HSA-5620924", "R-RNO-5620924"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR056457": {"description": "DOP1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "DOP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056458": {"description": "DOP1-like, middle TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_DOP1_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056459": {"description": "DOP1-like, TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_DOP1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056460": {"description": "DUF1512, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF1512_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056461": {"description": "DUF1512, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF1512_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056462": {"description": "Glycerol-3-phosphate acyltransferase RAM2/GPAT1-8, HAD-like domain", "go_ids": [], "go_terms": [], "name": "HAD_RAM2/GPAT1-8", "pathway_ids": ["PWY-5667", "PWY-8053", "PWY-7587", "PWY-8051", "PWY-8055", "PWY-6453", "PWY-7411"], "pathways": ["PWY-5667:t:CDP-diacylglycerol biosynthesis I", "PWY-8053:t:anandamide biosynthesis II", "PWY-7587:t:oleate biosynthesis III (cyanobacteria)", "PWY-8051:t:anandamide biosynthesis I", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-7411:t:phosphatidate biosynthesis (yeast)"], "type": "Domain"}, "IPR056463": {"description": "DUF7373, C-terminal", "go_ids": [], "go_terms": [], "name": "DUF7373_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056464": {"description": "DotM, C-terminal cytoplasmic domain", "go_ids": [], "go_terms": [], "name": "DotM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056465": {"description": "DotY", "go_ids": [], "go_terms": [], "name": "DotY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056466": {"description": "Guanine nucleotide exchange factor DBS-like, spectrin-like", "go_ids": [], "go_terms": [], "name": "Spectrin_DBS", "pathway_ids": ["R-RNO-9013026", "R-HSA-193648", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-HSA-416482", "R-RNO-9013149", "R-HSA-9013106", "R-RNO-9013148", "R-MMU-9013148", "R-HSA-9013404", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-193634", "R-HSA-8980692", "R-RNO-416482", "R-MMU-9013026", "R-MMU-416482", "R-HSA-9013148", "R-MMU-193648", "R-HSA-9013026", "R-RNO-9013408", "R-RNO-9013106", "R-HSA-9013408", "R-MMU-9013149", "R-RNO-193648"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-193648:r:NRAGE signals death through JNK", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-193634:r:Axonal growth inhibition (RHOA activation)", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-MMU-193648:r:NRAGE signals death through JNK", "R-HSA-9013026:r:RHOB GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-193648:r:NRAGE signals death through JNK"], "type": "Domain"}, "IPR056467": {"description": "GTF3C1, extended winged-helix domain", "go_ids": [], "go_terms": [], "name": "eWH_GTF3C1", "pathway_ids": ["R-MMU-76061", "R-RNO-76061", "R-MMU-76066", "R-HSA-749476", "R-RNO-76066", "R-HSA-76066", "R-HSA-76061"], "pathways": ["R-MMU-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-RNO-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-MMU-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-RNO-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "type": "Domain"}, "IPR056468": {"description": "Guanine-nucleotide exchange factor YEL1, PH domain", "go_ids": [], "go_terms": [], "name": "PH_GEF_YEL1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056469": {"description": "Half a barrel domain", "go_ids": [], "go_terms": [], "name": "HAB_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056470": {"description": "L-lysine 4-chlorinase BesD/L-lysine 5-chlorinase HalB-like", "go_ids": [], "go_terms": [], "name": "BesD/HalB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056471": {"description": "HD-CE", "go_ids": [], "go_terms": [], "name": "HD-CE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056472": {"description": "Head completion protein", "go_ids": [], "go_terms": [], "name": "HCP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056473": {"description": "Utp10/HEAT1, HEAT-repeats domain", "go_ids": [], "go_terms": [], "name": "HEAT_Utp10/HEAT1", "pathway_ids": ["R-DME-6791226", "R-CEL-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR056474": {"description": "Helicase SEN1, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "SEN1_barrel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056475": {"description": "Hemicentin/VWA7, galactose-binding domain-like", "go_ids": [], "go_terms": [], "name": "GBD_Hemicentin/VWA7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056476": {"description": "Capsid protein Vp24", "go_ids": [], "go_terms": [], "name": "Vp24_capsid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056477": {"description": "Capsid protein Vp25", "go_ids": [], "go_terms": [], "name": "Vp25_capsid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056479": {"description": "CARF-associated, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "CARF-assoc_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056480": {"description": "Hfq-like domain", "go_ids": [], "go_terms": [], "name": "Phage_Hfq_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056482": {"description": "Krimper, first tudor domain", "go_ids": [], "go_terms": [], "name": "Tudor_krimper_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056483": {"description": "Histidine N-acetyltransferase, C-terminal", "go_ids": [], "go_terms": [], "name": "Hisat_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056484": {"description": "Histone acetyltransferase p300/CREBBP, PHD domain", "go_ids": [], "go_terms": [], "name": "PHD_P300", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987", "R-MMU-8941858", "R-RNO-933541", "R-HSA-8936459", "R-CEL-9701898", "R-RNO-9018519", "R-HSA-9818030", "R-CEL-9617629", "R-HSA-9616222", "R-HSA-9701898", "R-HSA-9614657", "R-HSA-2122947", "R-MMU-6804760", "R-HSA-9931521", "R-HSA-6804760", "R-RNO-9759194", "R-MMU-3371568", "R-CEL-8939246", "R-MMU-350054", "R-HSA-6804114", "R-MMU-6804758", "R-HSA-9793380", "R-RNO-9841922", "R-RNO-5621575", "R-HSA-2644606", "R-HSA-9031628", "R-HSA-9768919", "R-HSA-9833109", "R-CEL-8951936", "R-HSA-8941856", "R-HSA-9705671", "R-CEL-8936459", "R-MMU-2122947", "R-HSA-9735871", "R-CEL-3899300", "R-MMU-9759194", "R-MMU-9029569", "R-HSA-3371568", "R-HSA-9818028", "R-HSA-9617629", "R-RNO-400206", "R-MMU-8951936", "R-HSA-9839394", "R-MMU-3899300", "R-RNO-9856649", "R-HSA-210744", "R-HSA-156711", "R-HSA-381340", "R-MMU-8866907", "R-MMU-9701898", "R-HSA-9707616", "R-HSA-6811555", "R-HSA-350054", "R-HSA-201722", "R-HSA-933541", "R-HSA-9909649", "R-RNO-8941856", "R-RNO-8866907", "R-CEL-9018519", "R-HSA-3214847", "R-HSA-9856649", "R-RNO-9617629", "R-HSA-2426168", "R-MMU-9707564", "R-MMU-9856649", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-1234158", "R-MMU-5689901", "R-MMU-201722", "R-MMU-8939246", "R-HSA-9818749", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-1234158", "R-RNO-350054", "R-HSA-9933387", "R-HSA-9707564", "R-CEL-9856649", "R-HSA-9018519", "R-HSA-8951936", "R-RNO-3134973", "R-MMU-8936459", "R-MMU-5250924", "R-MMU-5621575", "R-HSA-8941858", "R-MMU-3134973", "R-CEL-9759194", "R-MMU-9018519", "R-HSA-9013695", "R-HSA-8939243", "R-HSA-9818026", "R-HSA-400206", "R-HSA-3134973", "R-MMU-400206", "R-HSA-5617472", "R-HSA-9818027", "R-HSA-5689901", "R-HSA-9819196", "R-MMU-933541", "R-RNO-201722", "R-HSA-9818035", "R-CEL-201722", "R-MMU-9617629", "R-RNO-8939246", "R-HSA-1912408", "R-HSA-6804758", "R-RNO-3371568", "R-HSA-918233", "R-HSA-5621575", "R-HSA-9759194", "R-HSA-9029569", "R-HSA-2173796", "R-HSA-9931509", "R-CEL-1234158", "R-HSA-8866907", "R-HSA-9013508", "R-HSA-2894862", "R-RNO-9707564", "R-MMU-8939243", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-6803204", "R-HSA-9818032", "R-MMU-8941856", "R-HSA-5250924", "R-MMU-6811555", "R-RNO-1234158", "R-HSA-3899300", "R-HSA-2197563", "R-HSA-8939246", "R-CEL-8939243"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen 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"PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 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Involved in G2 Cell Cycle Arrest", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-3371568:r:Attenuation phase", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-9839394:r:TGFBR3 expression", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9707616:r:Heme signaling", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-3371568:r:Attenuation phase", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR056485": {"description": "KRIT1, ARM-repeats domain", "go_ids": [], 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domain", "go_ids": [], "go_terms": [], "name": "DUF6688_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056492": {"description": "Hsr-9, Tudor domain", "go_ids": [], "go_terms": [], "name": "SH3_Hsr9", "pathway_ids": ["R-CEL-3232118"], "pathways": ["R-CEL-3232118:r:SUMOylation of transcription factors"], "type": "Domain"}, "IPR056493": {"description": "HVO_0513-like, N-terminal", "go_ids": [], "go_terms": [], "name": "HVO_0513_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056494": {"description": "DUF7108, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF7108_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056495": {"description": "Dynamin-like GTPase MGM1-like, lipid interacting stalk", "go_ids": [], "go_terms": [], "name": "LIS_MGM1", "pathway_ids": ["R-SCE-190873", "R-SPO-190873", "R-SCE-196025", "R-SPO-196025"], "pathways": ["R-SCE-190873:r:Gap junction degradation", "R-SPO-190873:r:Gap junction degradation", "R-SCE-196025:r:Formation of annular gap junctions", "R-SPO-196025:r:Formation of annular gap junctions"], "type": "Domain"}, "IPR056496": {"description": "Dynein axonemal assembly factor 11-like, CS domain", "go_ids": [], "go_terms": [], "name": "CS_DNAAF11_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056497": {"description": "Dynein axonemal assembly factor 5, HEAT-repeat domain", "go_ids": [], "go_terms": [], "name": "HEAT_DAAF5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056498": {"description": "DAAF9, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DAAF9_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056499": {"description": "HPS5-like, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_HPS5-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056501": {"description": "HRPKS sdrA-like, NAD(P)-binding domain", "go_ids": [], "go_terms": [], "name": "NAD-bd_HRPKS_sdrA", "pathway_ids": ["PWY-7045", "PWY-7530", "PWY-7940", "PWY-6373", "PWY-7989", "PWY-8157", "PWY-8051", "PWY-7029", "PWY-6320", "PWY-6722", "PWY-8426", "PWY-7265", "PWY-7670", "PWY-6627", "PWY-6946", "PWY-7261", "PWY-7280", "PWY-7711", "PWY-6945", "PWY-7688", "PWY-7563", "PWY-6027", "PWY-7689", "PWY-6922", "PWY-7677", "PWY-7632", "PWY-7412", "PWY-7907", "PWY-7577", "PWY-6378", "PWY-8075", "PWY-7706", "PWY-7726", "PWY-6310", "PWY-7692", "PWY-6379", "PWY-7543", "PWY-7583", "PWY-6679", "PWY-7656", "PWY-7452", "PWY-8049", "PWY-7679", "PWY-7448", "PWY-7694", "PWY-7693", "PWY-7624", "PWY-7532", "PWY-6672", "PWY-7458", "PWY-7716", "PWY-7987", "PWY-4801", "PWY-7659", "PWY-5318", "PWY-7172", "PWY-7983", "PWY-7053", "PWY-7529", "PWY-6322", "PWY-6056", "PWY-8133", "PWY-5292", "PWY-8374", "PWY-8337", "PWY-5139", "PWY-5307", "PWY-8084", "PWY-7354", "PWY-6032", "PWY-7815", "PWY-7696", "PWY-8447", "PWY-7415", "PWY-7475", "PWY-7547", "PWY-7555", "PWY-7171", "PWY-7950", "PWY-7318", "PWY-8012", "PWY-7984", "PWY-7719", "PWY-8038", "PWY-7730", "PWY-7737", "PWY-5710", "PWY-7602", "PWY-6036", "PWY-8032", "PWY-7690", "PWY-7474", "PWY-7419", "PWY-7930", "PWY-7465", "PWY-84", "PWY-6316", "PWY-6842", "PWY-6749", "PWY-7668", "PWY-8343", "PWY-7471", "PWY-8151", "PWY-8047", "PWY-5048", "PWY-7470", "PWY-6920", "PWY-6763", "PWY-7811", "PWY-7673", "PWY-5313", "PWY-7769", "PWY-8243", "PWY-8326", "PWY-6397", "PWY-5679", "PWY-7727", "PWY-8040", "PWY-7735", "PWY-5284", "PWY-8152", "PWY-7746", "PWY-8231", "PWY-8464", "PWY-7702", "PWY-5984", "PWY-7816", "PWY-7687", "PWY-8407", "PWY-7818", "PWY-8036", "PWY-7660", "PWY-6944", "PWY-5975", "PWY-7407", "PWY-7713", "PWY-7599", "PWY-7049", "PWY-8082", "PWY-7669", "PWY-7601", "PWY-8116", "PWY-7988", "PWY-5477", "PWY-7954", "PWY-7450", "PWY-6312", "PWY-6442", "PWY-7728", "PWY-7382", "PWY-5473", "PWY-8045", "PWY-7585", "PWY-4922", "PWY-7821", "PWY-7460", "PWY-8053", "PWY-6930", "PWYG-321", "PWY-8166", "PWY-5875", "PWY-5660", "PWY-7621", "PWY-5794", "PWY-6799", "PWY-6314", "PWY-7612", "PWY-7714", "PWY-7401", "PWY-6039", "PWY-8035", "PWY-5475", "PWY-7050", "PWY-8210", "PWY-7672", "PWY-7464", "PWY-7473", "PWY-8272", "PWY-6958", "PWY-5317", "PWY-6948", "PWY-7695", "PWY-7986", "PWY-8438", "PWY-8058", "PWY-5903", "PWY-8366", "PWY-8327", "PWY-5846", "PWY-8434", "PWY-5353", "PWY-7352", "PWY-7405", "PWY-6407", "PWY-7168", "PWY-7671", "PWY-6453", "PWY-361", "PWY-3602", "PWY-7653", "PWY-7738", "PWY-6673", "PWY-7561", "PWY-7817", "PWY-8408", "PWY-761", "PWY-8371", "PWY-7461", "PWY-5268", "PWY-7708", "PWY-5994", "PWY-8055", "PWY-7606", "PWY-5400", "PWY-6971", "PWY-7592", "PWY-7565", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6373:t:acrylate degradation I", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-8157:t:avenanthramide biosynthesis", "PWY-8051:t:anandamide biosynthesis I", "PWY-7029:t:terminal olefins biosynthesis II", "PWY-6320:t:phaselate biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-7265:t:lampranthin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7261:t:anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)", "PWY-7280:t:ternatin C3 biosynthesis", "PWY-7711:t:calonectrin biosynthesis", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7688:t:dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-6027:t:capsiconiate biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-6922:t:L-Ndelta-acetylornithine biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7632:t:hinokiresinol biosynthesis", "PWY-7412:t:mycinamicin biosynthesis", "PWY-7907:t:(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-8075:t:(Kdo)2-lipid A biosynthesis (P. putida)", "PWY-7706:t:dapdiamides biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-7583:t:arachidonate biosynthesis II (bacteria)", "PWY-6679:t:jadomycin biosynthesis", "PWY-7656:t:Spodoptera littoralis pheromone biosynthesis", "PWY-7452:t:cyanidin dimalonylglucoside biosynthesis", "PWY-8049:t:pederin biosynthesis", "PWY-7679:t:anthocyanidin acylglucoside and acylsambubioside biosynthesis", "PWY-7448:t:galloylated catechin biosynthesis", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-7624:t:nystatin biosynthesis", "PWY-7532:t:acetylaszonalenin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7458:t:violdelphin biosynthesis", "PWY-7716:t:penicillin G and penicillin V biosynthesis", "PWY-7987:t:vanchrobactin biosynthesis", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-5318:t:calystegine biosynthesis", "PWY-7172:t:flavonol acylglucoside biosynthesis III - quercetin derivatives", "PWY-7983:t:pseudomonine biosynthesis", "PWY-7053:t:docosahexaenoate biosynthesis I (lower eukaryotes)", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-6056:t:dimethylsulfoniopropanoate degradation II (cleavage)", "PWY-8133:t:succinoglycan biosynthesis", "PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "PWY-8374:t:antimycin biosynthesis", "PWY-8337:t:gamma-butyrobetaine degradation I", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-5307:t:gentiodelphin biosynthesis", "PWY-8084:t:daurichromenate biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-6032:t:digitoxigenin biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-7696:t:citreoisocoumarin and bikisocoumarin biosynthesis", "PWY-8447:t:carminate biosynthesis", "PWY-7415:t:tylosin biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-7950:t:diadinoxanthin and fucoxanthin biosynthesis (diatoms)", "PWY-7318:t:dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-7984:t:acinetobactin biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8038:t:naphthomycin biosynthesis", "PWY-7730:t:T-2 toxin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-5710:t:capsaicin biosynthesis", "PWY-7602:t:icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-7474:t:avenacin A-2 biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7930:t:pyoluteorin biosynthesis", "PWY-7465:t:3,3'-thiodipropanoate degradation", "PWY-84:t:resveratrol biosynthesis", "PWY-6316:t:aromatic polyketides biosynthesis", "PWY-6842:t:glutathione-mediated detoxification II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7668:t:apicidin F biosynthesis", "PWY-8343:t:leinamycin biosynthesis", "PWY-7471:t:D-carnitine degradation I", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8047:t:bryostatin biosynthesis", "PWY-5048:t:rosmarinic acid biosynthesis I", "PWY-7470:t:phosphatidylcholine biosynthesis VII", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-6763:t:salicortin biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-7769:t:phosalacine biosynthesis", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-8326:t:grayanate biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-5679:t:clavulanate biosynthesis", "PWY-7727:t:docosahexaenoate biosynthesis IV (4-desaturase, mammals)", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-5284:t:shisonin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-7746:t:mycobacterial sulfolipid biosynthesis", "PWY-8231:t:Escherichia coli serotype O:127 O antigen biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-7702:t:sch210971 and sch210972 biosynthesis", "PWY-5984:t:rifamycin B biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7687:t:stipitatate biosynthesis", "PWY-8407:t:fumagillin biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-8036:t:chaxamycin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7407:t:aurachin A, B, C and D biosynthesis", "PWY-7713:t:nivalenol biosynthesis", "PWY-7599:t:anditomin biosynthesis", "PWY-7049:t:icosapentaenoate biosynthesis II (6-desaturase, mammals)", "PWY-8082:t:glycine lipid biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-7601:t:arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)", "PWY-8116:t:ochratoxin A biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-5477:t:gallotannin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7728:t:(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)", "PWY-7382:t:lipoate biosynthesis and incorporation IV (yeast)", "PWY-5473:t:hydroxycinnamic acid serotonin amides biosynthesis", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7585:t:docosahexaenoate biosynthesis II (bacteria)", "PWY-4922:t:6-methoxymellein biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-8053:t:anandamide biosynthesis II", "PWY-6930:t:phenolic malonylglucosides biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8166:t:emodin biosynthesis", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-5794:t:malonate degradation I (biotin-independent)", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-6314:t:plumbagin biosynthesis", "PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7714:t:harzianum A and trichodermin biosynthesis", "PWY-7401:t:crotonate fermentation (to acetate and cyclohexane carboxylate)", "PWY-6039:t:chlorogenic acid biosynthesis I", "PWY-8035:t:streptovaricin biosynthesis", "PWY-5475:t:pentagalloylglucose biosynthesis", "PWY-7050:t:icosapentaenoate biosynthesis IV (bacteria)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7672:t:fusaric acid biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-6958:t:icosapentaenoate biosynthesis I (lower eukaryotes)", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7986:t:anguibactin biosynthesis", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-5903:t:bacillibactin biosynthesis", "PWY-8366:t:septacidin biosynthesis", "PWY-8327:t:atranorin biosynthesis", "PWY-5846:t:colchicine biosynthesis", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-5353:t:arachidonate biosynthesis I (6-desaturase, lower eukaryotes)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7405:t:aurachin RE biosynthesis", "PWY-6407:t:yersiniabactin biosynthesis", "PWY-7168:t:flavonol acylglucoside biosynthesis I - kaempferol derivatives", "PWY-7671:t:saframycin A biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-361:t:monolignol biosynthesis", "PWY-3602:t:L-carnitine degradation III", "PWY-7653:t:griseofulvin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-6673:t:caffeoylglucarate biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-8408:t:erinacine biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7461:t:hydroxycinnamate sugar acid ester biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-7708:t:lyngbyatoxin biosynthesis", "PWY-5994:t:palmitate biosynthesis I (type I fatty acid synthase)", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-5400:t:amaranthin biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-7592:t:arachidonate biosynthesis III (6-desaturase, mammals)", "PWY-7565:t:aspyridone A biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR056502": {"description": "KIAA0319-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "KIAA0319-like_C", "pathway_ids": ["R-RNO-8856828", "R-MMU-8856828", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-HSA-8856828"], "pathways": ["R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828:r:Clathrin-mediated endocytosis"], "type": "Domain"}, "IPR056503": {"description": "Dystrophin-1-like, spectrin repeat domain", "go_ids": [], "go_terms": [], "name": "Spectrin_Dys-1", "pathway_ids": ["R-CEL-9913351"], "pathways": ["R-CEL-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)"], "type": "Domain"}, "IPR056504": {"description": "HVO_0163, N-terminal HTH domain", "go_ids": [], "go_terms": [], "name": "HTH_HVO_0163_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056505": {"description": "HVO_0234-like, beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_HVO_0234", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056506": {"description": "iHD-CE", "go_ids": [], "go_terms": [], "name": "iHD-CE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056507": {"description": "wHTH-Hsp90, Na associated", "go_ids": [], "go_terms": [], "name": "wHTH-HSP90_Na-assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056508": {"description": "Hydroxyproline O-arabinosyltransferase-like domain", "go_ids": [], "go_terms": [], "name": "HPAT-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056509": {"description": "Imm33-like domain", "go_ids": [], "go_terms": [], "name": "Imm33-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056510": {"description": "Immunity protein WapI-like", "go_ids": [], "go_terms": [], "name": "WapI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056511": {"description": "Increased DNA methylation 1, C-terminal", "go_ids": [], "go_terms": [], "name": "IDM1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056512": {"description": "Putative E3 ubiquitin-protein ligase LIN, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LIN_N", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR056513": {"description": "INO80 complex subunit F", "go_ids": [], "go_terms": [], "name": "INO80F", "pathway_ids": ["R-BTA-5689603", "R-MMU-5696394", "R-HSA-5689603", "R-MMU-5689603", "R-RNO-5689603", "R-BTA-5696394", "R-RNO-5696394", "R-HSA-5696394"], "pathways": ["R-BTA-5689603:r:UCH proteinases", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5689603:r:UCH proteinases", "R-MMU-5689603:r:UCH proteinases", "R-RNO-5689603:r:UCH proteinases", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Domain"}, "IPR056514": {"description": "Putative E3 ubiquitin-protein ligase LIN, ARM repeats domain", "go_ids": [], "go_terms": [], "name": "ARM_LIN_2nd", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR056515": {"description": "INO80 complex subunit E, N-terminal", "go_ids": [], "go_terms": [], "name": "INO80E_N", "pathway_ids": ["R-BTA-5689603", "R-RNO-5689603", "R-HSA-5689603", "R-BTA-5696394", "R-RNO-5696394", "R-HSA-5696394"], "pathways": ["R-BTA-5689603:r:UCH proteinases", "R-RNO-5689603:r:UCH proteinases", "R-HSA-5689603:r:UCH proteinases", "R-BTA-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER"], "type": "Domain"}, "IPR056516": {"description": "Integrator complex subunit 7, N-terminal", "go_ids": [], "go_terms": [], "name": "INTS7_N", "pathway_ids": ["R-DME-6807505", "R-HSA-6807505", "R-BTA-6807505", "R-MMU-6807505", "R-DRE-6807505", "R-DDI-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR056517": {"description": "Integrator complex subunit 7, helical bundle", "go_ids": [], "go_terms": [], "name": "INTS7_HB", "pathway_ids": ["R-DME-6807505", "R-HSA-6807505", "R-BTA-6807505", "R-MMU-6807505", "R-DRE-6807505", "R-DDI-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-BTA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR056518": {"description": "Ints3-like, C-terminal", "go_ids": [], "go_terms": [], "name": "HEAT_Ints3_C", "pathway_ids": ["R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505", "R-DRE-6807505", "R-DDI-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR056519": {"description": "KANSL3, helical domain", "go_ids": [], "go_terms": [], "name": "KANSL3_1st", "pathway_ids": ["R-MMU-3214847", "R-MMU-9772755", "R-HSA-3214847", "R-HSA-9772755", "R-RNO-3214847", "R-DRE-3214847", "R-RNO-9772755"], "pathways": ["R-MMU-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-RNO-3214847:r:HATs acetylate histones", "R-DRE-3214847:r:HATs acetylate histones", "R-RNO-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Domain"}, "IPR056520": {"description": "KDM8, N-terminal", "go_ids": [], "go_terms": [], "name": "ARM_KDM8_N", "pathway_ids": ["R-DRE-9629569", "R-RNO-9629569", "R-MMU-9629569", "R-XTR-9629569", "R-BTA-9629569", "R-HSA-9629569"], "pathways": ["R-DRE-9629569:r:Protein hydroxylation", "R-RNO-9629569:r:Protein hydroxylation", "R-MMU-9629569:r:Protein hydroxylation", "R-XTR-9629569:r:Protein hydroxylation", "R-BTA-9629569:r:Protein hydroxylation", "R-HSA-9629569:r:Protein hydroxylation"], "type": "Domain"}, "IPR056521": {"description": "E3 ubiquitin-protein ligase MARCHF6-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MARCHF6-like_C", "pathway_ids": ["PWY-7511", "R-HSA-901032"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)"], "type": "Domain"}, "IPR056522": {"description": "Uncharacterized bromodomain-containing protein 10, helical domain", "go_ids": [], "go_terms": [], "name": "KIAA2026_hel", 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{"description": "HVO_1552, C-terminal", "go_ids": [], "go_terms": [], "name": "HVO_1552_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056526": {"description": "HVO_1752, TRASH domain", "go_ids": [], "go_terms": [], "name": "TRASH_HVO_1752", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056527": {"description": "E3 ubiquitin-protein ligase RFWD3-like, WD40 domain", "go_ids": [], "go_terms": [], "name": "WD40_RFWD3", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR056528": {"description": "HVO_2833, C-terminal", "go_ids": [], "go_terms": [], "name": "HVO_2833_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056529": {"description": "HVO_2928, N-terminal", "go_ids": [], "go_terms": [], "name": "HVO_2928_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056530": {"description": "E3 ubiquitin-protein ligase UBR4-like domain", "go_ids": [], "go_terms": [], "name": "UBR4-like_dom", 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"R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", 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confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR056538": {"description": "ArlX", "go_ids": [], "go_terms": [], "name": "ArlX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056539": {"description": "NuiA-like", "go_ids": [], "go_terms": [], "name": "NuiA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056540": {"description": "Nucleoporin POM152, N-terminal transmembrane domain", "go_ids": [], "go_terms": [], "name": "TMD_POM152", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056541": {"description": "Nucleoporin POM152, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig-like_POM152", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056542": {"description": "Nucleoporin POM152, first Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig-like_POM152_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056543": {"description": "Nucleoporin POM152, ninth Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig-like_POM152_9th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056544": {"description": "Nucleoporin POM152, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig_POM152", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056545": {"description": "ASCIZ, first and second C2H2 zinc finger domains", "go_ids": [], "go_terms": [], "name": "C2H2_ASCIZ_1st_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056546": {"description": "MreB/MamK-like", "go_ids": [], "go_terms": [], "name": "MreB_MamK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056547": {"description": "NUP160, helical domain", "go_ids": [], "go_terms": [], "name": "NUP160_helical", "pathway_ids": ["R-HSA-180910", "R-HSA-191859", "R-HSA-2467813", "R-HSA-3108214", "R-HSA-9705671", "R-MMU-3232142", "R-MMU-2467813", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-MMU-68877", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-9615933", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-MMU-4085377", "R-MMU-4551638", "R-HSA-3371453", "R-HSA-68877", "R-HSA-165054", "R-HSA-4570464", "R-DME-4615885", "R-HSA-4615885", "R-MMU-9648025", "R-HSA-4551638", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-MMU-2500257", "R-HSA-2500257", "R-DME-3371453", "R-HSA-168276", "R-MMU-141444", "R-HSA-168271", "R-HSA-6784531", "R-DME-4551638", "R-MMU-3301854", "R-HSA-141444", "R-HSA-4085377", "R-HSA-168325", "R-DME-159227", "R-HSA-9648025", "R-MMU-170822", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-159230", "R-DME-9615933", "R-HSA-9615933", "R-MMU-159227", "R-DME-3301854", "R-HSA-5619107", "R-HSA-5663220", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-MMU-5663220"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-191859:r:snRNP Assembly", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR056548": {"description": "Nucleoporin nup120-like, HEAT repeat domain, fungal", "go_ids": [], "go_terms": [], "name": "HEAT_Nup120", "pathway_ids": ["R-SPO-3371453", "R-SPO-4570464", "R-SPO-159236", "R-SPO-159227", "R-SPO-159231", "R-SPO-4551638", "R-SPO-9615933", "R-SPO-4085377"], "pathways": ["R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins"], "type": "Domain"}, "IPR056549": {"description": "Nucleolar protein 4, helical domain", "go_ids": [], "go_terms": [], "name": "HTH_NOL4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056550": {"description": "Nucleolar protein 10-like, second domain", "go_ids": [], "go_terms": [], "name": "NOL10_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056551": {"description": "Nucleolar protein 10-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_NOL10_N", "pathway_ids": ["R-DDI-6782135", "R-HSA-9930044", "R-MMU-5674135", "R-DRE-5674135", "R-HSA-168638", "R-HSA-9772755", "R-DRE-8943724", "R-HSA-8951664", "R-HSA-349425", "R-DRE-9639288", "R-HSA-73856", "R-MMU-9639288", "R-DDI-6782210", "R-RNO-2173788", "R-HSA-72187", "R-DDI-72163", "R-DRE-6804757", "R-MMU-380284", "R-MMU-2565942", "R-HSA-9639288", "R-MMU-380320", "R-HSA-9764790", "R-MMU-349425", "R-RNO-73856", "R-DRE-159236", "R-DRE-9930044", "R-MMU-8951664", "R-DRE-73856", "R-DRE-166208", "R-DRE-1632852", "R-HSA-177929", "R-CFA-168638", "R-RNO-159236", "R-MMU-9772755", "R-HSA-72165", "R-RNO-5674135", "R-DRE-9856530", "R-MMU-5620912", "R-BTA-168638", "R-HSA-9918481", "R-MMU-9930044", "R-GGA-2173788", "R-HSA-2173788", "R-MMU-380259", "R-DRE-5218920", "R-CFA-177929", "R-MMU-72163", "R-MMU-73856", "R-MMU-380270", "R-DDI-6781823", "R-DRE-389357", "R-BTA-2173788", "R-CFA-428930", "R-MMU-159236", "R-SCE-3214815", "R-HSA-72163", "R-DRE-1257604", "R-DDI-5674135", "R-MMU-72187", "R-XTR-9930044", "R-BTA-428930", "R-MMU-72165", "R-DRE-165159", "R-BTA-177929", "R-MMU-8854518", "R-HSA-428930", "R-HSA-159236", "R-DRE-3371571", "R-MMU-2173788", "R-SPO-72163", "R-DRE-380972", "R-HSA-194138", "R-DRE-5628897"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-HSA-9930044:r:Nuclear RNA decay", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-DRE-5674135:r:MAP2K and MAPK activation", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-DRE-8943724:r:Regulation of PTEN gene transcription", "R-HSA-8951664:r:Neddylation", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DRE-9639288:r:Amino acids regulate mTORC1", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-9639288:r:Amino acids regulate mTORC1", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-72187:r:mRNA 3'-end processing", "R-DDI-72163:r:mRNA Splicing - Major Pathway", "R-DRE-6804757:r:Regulation of TP53 Degradation", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-9764790:r:Positive Regulation of CDH1 Gene Transcription", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-9930044:r:Nuclear RNA decay", "R-MMU-8951664:r:Neddylation", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-166208:r:mTORC1-mediated signalling", "R-DRE-1632852:r:Macroautophagy", "R-HSA-177929:r:Signaling by EGFR", "R-CFA-168638:r:NOD1/2 Signaling Pathway", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-DRE-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-9930044:r:Nuclear RNA decay", "R-GGA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-DRE-5218920:r:VEGFR2 mediated vascular permeability", "R-CFA-177929:r:Signaling by EGFR", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-389357:r:CD28 dependent PI3K/Akt signaling", "R-BTA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-CFA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-SCE-3214815:r:HDACs deacetylate histones", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-1257604:r:PIP3 activates AKT signaling", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-MMU-72187:r:mRNA 3'-end processing", "R-XTR-9930044:r:Nuclear RNA decay", "R-BTA-428930:r:Thromboxane signalling through TP receptor", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DRE-165159:r:MTOR signalling", "R-BTA-177929:r:Signaling by EGFR", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-428930:r:Thromboxane signalling through TP receptor", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-3371571:r:HSF1-dependent transactivation", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling", "R-SPO-72163:r:mRNA Splicing - Major Pathway", "R-DRE-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-194138:r:Signaling by VEGF", "R-DRE-5628897:r:TP53 Regulates Metabolic Genes"], "type": "Domain"}, "IPR056553": {"description": "Mug60/KHD4, KH type I domain", "go_ids": [], "go_terms": [], "name": "KH_Mug60-KHD4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056555": {"description": "NFD4, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NFD4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056556": {"description": "Lysophospholipase NTE1-like, P-loop domain", "go_ids": [], "go_terms": [], "name": "NTE1_P-loop_dom", "pathway_ids": ["PWY-7409", "R-CEL-6814848", "R-DME-6814848", "R-SPO-6814848", "R-SCE-6814848", "R-HSA-6814848", "R-MMU-6814848"], "pathways": ["PWY-7409:t:phospholipid remodeling (phosphatidylethanolamine, yeast)", "R-CEL-6814848:r:Glycerophospholipid catabolism", "R-DME-6814848:r:Glycerophospholipid catabolism", "R-SPO-6814848:r:Glycerophospholipid catabolism", "R-SCE-6814848:r:Glycerophospholipid catabolism", "R-HSA-6814848:r:Glycerophospholipid catabolism", "R-MMU-6814848:r:Glycerophospholipid catabolism"], "type": "Domain"}, "IPR056557": {"description": "NELF-A, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NELF-A_N", "pathway_ids": ["R-DME-113418", "R-MMU-6796648", "R-DME-674695", "R-HSA-167238", "R-MMU-113418", "R-HSA-167243", "R-DME-6796648", "R-HSA-167242", "R-DME-75955", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-674695", "R-MMU-112382", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-75955", "R-HSA-167152", "R-HSA-113418", "R-HSA-674695", "R-HSA-112382"], "pathways": ["R-DME-113418:r:Formation of the Early Elongation Complex", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR056558": {"description": "LAMB1/2/3/4, helical domain", "go_ids": [], "go_terms": [], "name": "LAMB1-4_helical", "pathway_ids": ["R-HSA-1474228", "R-HSA-9925563", "R-HSA-2214320", "R-HSA-8874081", "R-HSA-3000157", "R-HSA-3000178", "R-HSA-9913351", "R-HSA-3000171", "R-HSA-9619665", "R-HSA-373760", "R-HSA-9638630", "R-HSA-2022090", "R-HSA-8957275", "R-HSA-446107", "R-HSA-381426"], "pathways": ["R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2214320:r:Anchoring fibril formation", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-3000157:r:Laminin interactions", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR056559": {"description": "Nodulin homeobox, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NDX_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056560": {"description": "Nodulin homeobox, homeobox-like domain", "go_ids": [], "go_terms": [], "name": "HTH_NDX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056561": {"description": "NFP/LYK4/5, first LysM domain", "go_ids": [], "go_terms": [], "name": "NFP_LYK_LysM1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056562": {"description": "LYK3/4/5, second LysM domain", "go_ids": [], "go_terms": [], "name": "LysM2_CERK1_LYK3_4_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056563": {"description": "LYK4/5, third LysM domain", "go_ids": [], "go_terms": [], "name": "LysM3_LYK4_5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056564": {"description": "KY-like, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig-like_KY", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056565": {"description": "Activating transcription factor 7-interacting protein, Fn3 domain", "go_ids": [], "go_terms": [], "name": "Fn3_ATF7IP", "pathway_ids": ["R-MMU-9843940", "R-MMU-3214841", "R-DRE-9843940", "R-DRE-3214841", "R-HSA-3214841", "R-GGA-3214841", "R-HSA-9843970", "R-DRE-9843970", "R-HSA-9843940", "R-GGA-9843970", "R-GGA-9843940"], "pathways": ["R-MMU-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-DRE-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-GGA-3214841:r:PKMTs methylate histone lysines", "R-HSA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-DRE-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-GGA-9843970:r:Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-GGA-9843940:r:Regulation of endogenous retroelements by KRAB-ZFP proteins"], "type": "Domain"}, "IPR056566": {"description": "CPBP family lipoprotein N-acylation protein LnsB-like", "go_ids": [], "go_terms": [], "name": "Acyl_LnsB_CPBP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056567": {"description": "Lipoprotein N-acylation protein LnsA-like", "go_ids": [], "go_terms": [], "name": "Acyl_LnsA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056569": {"description": "Flagella accessory protein J-like", "go_ids": [], "go_terms": [], "name": "FlaJ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056570": {"description": "PilB3-like, N-terminal", "go_ids": [], "go_terms": [], "name": "PilB3-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056571": {"description": "PilB3-like, C-terminal", "go_ids": [], "go_terms": [], "name": "PilB3-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056572": {"description": "PaaD, zinc beta ribbon domain", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_PaaD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056574": {"description": "MAP kinase-activating death domain protein, death domain", "go_ids": [], "go_terms": [], "name": "Death_MADD", "pathway_ids": ["R-RNO-8876198", "R-RNO-5357905", "R-HSA-8876198", "R-HSA-5357905", "R-MMU-8876198", "R-CEL-8876198", "R-DME-8876198", "R-MMU-5357905"], "pathways": ["R-RNO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-CEL-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-5357905:r:Regulation of TNFR1 signaling"], "type": "Domain"}, "IPR056575": {"description": "MCM3-like, winged helix domain", "go_ids": [], "go_terms": [], "name": "WH_MCM3_C", "pathway_ids": ["R-XTR-69052", "R-HSA-68949", "R-SPO-68867", "R-MMU-68867", "R-SPO-176187", "R-HSA-176974", "R-MMU-69052", "R-DME-68949", "R-XTR-68962", "R-MMU-68962", "R-BTA-69052", "R-BTA-68949", "R-MMU-68949", "R-DME-69052", "R-SPO-69052", "R-BTA-68962", "R-SCE-68962", "R-SCE-69052", "R-BTA-176187", "R-DME-68962", "R-HSA-69052", "R-XTR-68949", "R-XTR-68867", "R-MMU-176187", "R-HSA-68962", "R-DME-176187", "R-SPO-68962", "R-SPO-68949", "R-SCE-176187", "R-SCE-68867", "R-HSA-176187", "R-BTA-68867", "R-DME-68867", "R-HSA-68867"], "pathways": ["R-XTR-69052:r:Switching of origins to a post-replicative state", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68867:r:Assembly of the pre-replicative complex", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-69052:r:Switching of origins to a post-replicative state", "R-DME-68949:r:Orc1 removal from chromatin", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-BTA-69052:r:Switching of origins to a post-replicative state", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-DME-69052:r:Switching of origins to a post-replicative state", "R-SPO-69052:r:Switching of origins to a post-replicative state", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SCE-69052:r:Switching of origins to a post-replicative state", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-DME-68962:r:Activation of the pre-replicative complex", "R-HSA-69052:r:Switching of origins to a post-replicative state", "R-XTR-68949:r:Orc1 removal from chromatin", "R-XTR-68867:r:Assembly of the pre-replicative complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-SPO-68949:r:Orc1 removal from chromatin", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SCE-68867:r:Assembly of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-HSA-68867:r:Assembly of the pre-replicative complex"], "type": "Domain"}, "IPR056576": {"description": "MGAT4 A/B/C, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MGAT4_A/B/C_C", "pathway_ids": ["PWY-7426", "R-BTA-8957275", "R-RNO-381426", "R-HSA-381426", "R-RNO-975577", "R-DRE-975577", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-9694548", "R-BTA-975577", "R-HSA-975577", "R-HSA-8957275", "R-SSC-975577", "R-MMU-975577", "R-MMU-8957275"], "pathways": ["PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-975577:r:N-Glycan antennae elongation", "R-DRE-975577:r:N-Glycan antennae elongation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9694548:r:Maturation of spike protein", "R-BTA-975577:r:N-Glycan antennae elongation", "R-HSA-975577:r:N-Glycan antennae elongation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-975577:r:N-Glycan antennae elongation", "R-MMU-975577:r:N-Glycan antennae elongation", "R-MMU-8957275:r:Post-translational protein phosphorylation"], "type": "Domain"}, "IPR056577": {"description": "Gp84-like", "go_ids": [], "go_terms": [], "name": "Phage_Gp84", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056578": {"description": "N4BP1, C-terminal UBA domain", "go_ids": [], "go_terms": [], "name": "UBA_N4BP1_C", "pathway_ids": ["R-HSA-9758274", "R-DRE-9758274", "R-XTR-9758274", "R-MMU-9758274"], "pathways": ["R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-DRE-9758274:r:Regulation of NF-kappa B signaling", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-9758274:r:Regulation of NF-kappa B signaling"], "type": "Domain"}, "IPR056579": {"description": "E3 UFM1-protein ligase 1-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Ufl1_N", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-BTA-983168", "R-DDI-983168", "R-DME-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-MMU-983168", "R-DRE-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR056580": {"description": "E3 UFM1-protein ligase 1-like domain", "go_ids": [], "go_terms": [], "name": "Ufl1_dom", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-BTA-983168", "R-DDI-983168", "R-DME-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-MMU-983168", "R-DRE-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR056581": {"description": "Edg1/GEMIN4, TPR repeats region", "go_ids": [], "go_terms": [], "name": "TPR_Edg1_GEMIN4", "pathway_ids": ["R-HSA-9754678", "R-HSA-191859"], "pathways": ["R-HSA-9754678:r:SARS-CoV-2 modulates host translation machinery", "R-HSA-191859:r:snRNP Assembly"], "type": "Domain"}, "IPR056582": {"description": "EDRF1, N-terminal", "go_ids": [], "go_terms": [], "name": "EDRF1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056583": {"description": "EDRF1, TPR repeats region", "go_ids": [], "go_terms": [], "name": "EDRF1_TPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056584": {"description": "EF-hand", "go_ids": [], "go_terms": [], "name": "EF-hand_15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056585": {"description": "Leprecan-like alpha-helical domain", "go_ids": [], "go_terms": [], "name": "Leprecan_dom", "pathway_ids": ["PWY-7894", "R-RNO-1650814", "R-MMU-1650814", "R-HSA-1650814", "R-GGA-1650814"], "pathways": ["PWY-7894:t:procollagen hydroxylation and glycosylation", "R-RNO-1650814:r:Collagen biosynthesis and modifying enzymes", "R-MMU-1650814:r:Collagen biosynthesis and modifying enzymes", "R-HSA-1650814:r:Collagen biosynthesis and modifying enzymes", "R-GGA-1650814:r:Collagen biosynthesis and modifying enzymes"], "type": "Domain"}, "IPR056586": {"description": "PLCG1, EF-hand", "go_ids": [], "go_terms": [], "name": "EF-hand_PLCG1", "pathway_ids": ["PWY-6367", "PWY-7039", "PWY-6351", "PWY-8052", "R-MMU-5607764", "R-MMU-114604", "R-RNO-5621480", "R-HSA-166016", "R-HSA-2871796", "R-HSA-167021", "R-HSA-1489509", "R-RNO-202433", "R-HSA-5654228", "R-MMU-210990", "R-CEL-5654219", "R-RNO-2871809", "R-MMU-5654221", "R-MMU-2871796", "R-MMU-201556", "R-RNO-2029485", "R-RNO-210990", "R-HSA-8853659", "R-CEL-5654228", "R-MMU-2029485", "R-RNO-9026527", "R-HSA-5621480", "R-HSA-9664565", "R-HSA-5655302", "R-HSA-5654221", "R-MMU-186763", "R-HSA-114604", "R-HSA-212718", "R-RNO-212718", "R-RNO-201556", "R-HSA-9026527", "R-CEL-1855204", "R-HSA-9665686", "R-HSA-983695", "R-RNO-8853659", "R-HSA-2424491", "R-MMU-166016", "R-HSA-9034793", "R-MMU-8853659", "R-HSA-5637810", "R-HSA-5218921", "R-CEL-212718", "R-MMU-5654219", "R-RNO-5654228", "R-HSA-1855204", "R-HSA-418890", "R-CEL-186763", "R-HSA-9664323", "R-HSA-9680350", "R-RNO-2871796", "R-MMU-5654227", "R-HSA-5655253", "R-HSA-202433", "R-RNO-1169408", "R-HSA-2029485", "R-HSA-9665348", "R-CEL-5654227", "R-HSA-1169408", "R-HSA-1251932", "R-CEL-5607764", "R-MMU-9034793", "R-HSA-210990", "R-CEL-5654221", "R-HSA-1236382", "R-MMU-5654228", "R-MMU-1855204", "R-HSA-5607764", "R-MMU-5218921", "R-MMU-5621480", "R-HSA-5655291", "R-MMU-202433", "R-CEL-202433", "R-HSA-5655332", "R-RNO-9034793", "R-HSA-2871809", "R-HSA-9679191", "R-MMU-983695", "R-MMU-1169408", "R-RNO-5654221", "R-HSA-186763", "R-HSA-5654227", "R-RNO-114604", "R-RNO-5218921", "R-MMU-212718", "R-HSA-5654219", "R-CEL-1169408", "R-RNO-2424491", "R-RNO-5607764", "R-MMU-2871809", "R-HSA-201556", "R-RNO-983695", "R-RNO-1855204", "R-MMU-2424491", "R-HSA-9027277", "R-RNO-5654227", "R-RNO-5654219", "R-RNO-166016", "R-CEL-114604", "R-HSA-9725370", "R-RNO-186763", "R-MMU-9026527"], "pathways": ["PWY-6367:t:D-myo-inositol-5-phosphate metabolism", "PWY-7039:t:phosphatidate metabolism, as a signaling molecule", "PWY-6351:t:D-myo-inositol (1,4,5)-trisphosphate biosynthesis", "PWY-8052:t:2-arachidonoylglycerol biosynthesis", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-114604:r:GPVI-mediated activation cascade", "R-RNO-5621480:r:Dectin-2 family", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-2871796:r:FCERI mediated MAPK activation", "R-HSA-167021:r:PLC-gamma1 signalling", "R-HSA-1489509:r:DAG and IP3 signaling", "R-RNO-202433:r:Generation of second messenger molecules", "R-HSA-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-210990:r:PECAM1 interactions", "R-CEL-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-2871809:r:FCERI mediated Ca+2 mobilization", "R-MMU-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-2871796:r:FCERI mediated MAPK activation", "R-MMU-201556:r:Signaling by ALK", "R-RNO-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-8853659:r:RET signaling", "R-CEL-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-2029485:r:Role of phospholipids in phagocytosis", "R-RNO-9026527:r:Activated NTRK2 signals through PLCG1", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-MMU-186763:r:Downstream signal transduction", "R-HSA-114604:r:GPVI-mediated activation cascade", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-201556:r:Signaling by ALK", "R-HSA-9026527:r:Activated NTRK2 signals through PLCG1", "R-CEL-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-8853659:r:RET signaling", "R-HSA-2424491:r:DAP12 signaling", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9034793:r:Activated NTRK3 signals through PLCG1", "R-MMU-8853659:r:RET signaling", "R-HSA-5637810:r:Constitutive Signaling by EGFRvIII", "R-HSA-5218921:r:VEGFR2 mediated cell proliferation", "R-CEL-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-CEL-186763:r:Downstream signal transduction", "R-HSA-9664323:r:FCGR3A-mediated IL10 synthesis", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-RNO-2871796:r:FCERI mediated MAPK activation", "R-MMU-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-5655253:r:Signaling by FGFR2 in disease", "R-HSA-202433:r:Generation of second messenger molecules", "R-RNO-1169408:r:ISG15 antiviral mechanism", "R-HSA-2029485:r:Role of phospholipids in phagocytosis", "R-HSA-9665348:r:Signaling by ERBB2 ECD mutants", "R-CEL-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-1251932:r:PLCG1 events in ERBB2 signaling", "R-CEL-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-210990:r:PECAM1 interactions", "R-CEL-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-1236382:r:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-MMU-5654228:r:Phospholipase C-mediated cascade, FGFR4", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-5621480:r:Dectin-2 family", "R-HSA-5655291:r:Signaling by FGFR4 in disease", "R-MMU-202433:r:Generation of second messenger molecules", "R-CEL-202433:r:Generation of second messenger molecules", "R-HSA-5655332:r:Signaling by FGFR3 in disease", "R-RNO-9034793:r:Activated NTRK3 signals through PLCG1", "R-HSA-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-1169408:r:ISG15 antiviral mechanism", "R-RNO-5654221:r:Phospholipase C-mediated cascade, FGFR2", "R-HSA-186763:r:Downstream signal transduction", "R-HSA-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-114604:r:GPVI-mediated activation cascade", "R-RNO-5218921:r:VEGFR2 mediated cell proliferation", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-RNO-2424491:r:DAP12 signaling", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-2871809:r:FCERI mediated Ca+2 mobilization", "R-HSA-201556:r:Signaling by ALK", "R-RNO-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-2424491:r:DAP12 signaling", "R-HSA-9027277:r:Erythropoietin activates Phospholipase C gamma (PLCG)", "R-RNO-5654227:r:Phospholipase C-mediated cascade, FGFR3", "R-RNO-5654219:r:Phospholipase C-mediated cascade: FGFR1", "R-RNO-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1"], "type": "Domain"}, "IPR056587": {"description": "EFCAB10, C-terminal EF-hand", "go_ids": [], "go_terms": [], "name": "EF_EFCAB10_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056588": {"description": "LRP2, EGF-like domain", "go_ids": [], "go_terms": [], "name": "EGF_LRP2", "pathway_ids": ["R-MMU-975634", "R-MMU-8856828", "R-RNO-9758890", "R-RNO-196791", "R-HSA-196791", "R-RNO-8856825", "R-HSA-8856825", "R-MMU-8856825", "R-MMU-9758890", "R-HSA-8856828", "R-RNO-8856828", "R-RNO-975634", "R-HSA-9758890", "R-HSA-975634"], "pathways": ["R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9758890:r:Transport of RCbl within the body", "R-RNO-196791:r:Vitamin D (calciferol) metabolism", "R-HSA-196791:r:Vitamin D (calciferol) metabolism", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-9758890:r:Transport of RCbl within the body", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-HSA-9758890:r:Transport of RCbl within the body", "R-HSA-975634:r:Retinoid metabolism and transport"], "type": "Domain"}, "IPR056589": {"description": "Egal-1, winged helix domain", "go_ids": [], "go_terms": [], "name": "WH_Egal-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056590": {"description": "Mua-3/Mup-4, EGF-like domain", "go_ids": [], "go_terms": [], "name": "Mua-3/Mup-4_EGF", "pathway_ids": ["R-CEL-216083", "R-CEL-1474228", "R-CEL-2129379", "R-CEL-8957275", "R-CEL-381426", "R-CEL-1566948", "R-CEL-2173789"], "pathways": ["R-CEL-216083:r:Integrin cell surface interactions", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-1566948:r:Elastic fibre formation", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs"], "type": "Domain"}, "IPR056591": {"description": "ELP3-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ELP3-like_N", "pathway_ids": ["PWY-6829", "PWY-7888", "R-HSA-3214847"], "pathways": ["PWY-6829:t:tRNA methylation (yeast)", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "R-HSA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR056592": {"description": "F-box protein At3g26010-like, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_At3g26010-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056593": {"description": "LRRK2, ANK repeat domain", "go_ids": [], "go_terms": [], "name": "ANK_LRRK2", "pathway_ids": ["R-MMU-8857538", "R-HSA-8857538"], "pathways": ["R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Domain"}, "IPR056594": {"description": "F-box protein AT5G49610-like, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "AT5G49610-like_b-prop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056595": {"description": "FACT complex subunit SPT16, PH-like domain", "go_ids": [], "go_terms": [], "name": "Fact-SPT16_PH", "pathway_ids": ["R-CEL-75955", "R-SPO-674695", "R-MMU-6796648", "R-DME-674695", "R-HSA-167238", "R-HSA-167243", "R-DME-6796648", "R-SCE-6804756", "R-MMU-6804756", "R-DME-75955", "R-HSA-6796648", "R-SPO-6804756", "R-MMU-75955", "R-MMU-112382", "R-MMU-674695", "R-DME-6804756", "R-CEL-674695", "R-HSA-167287", "R-HSA-167246", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-HSA-6804756", "R-DDI-674695", "R-CEL-112382", "R-HSA-167152", "R-SCE-674695", "R-DDI-6796648", "R-HSA-75955", "R-DDI-6804756", "R-CEL-6804756", "R-SPO-6796648", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382", "R-SCE-6796648"], "pathways": ["R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-DDI-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-CEL-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes"], "type": "Domain"}, "IPR056596": {"description": "FAD synthase, middle domain", "go_ids": [], "go_terms": [], "name": "FLAD1_M", "pathway_ids": ["PWY-5381", "PWY-6168", "PWY-6167", "PWY-7761", "R-DRE-196843", "R-RNO-196843", "R-HSA-196843", "R-CEL-196843", "R-MMU-196843"], "pathways": ["PWY-5381:t:NAD salvage (plants)", "PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-6167:t:flavin biosynthesis II (archaea)", "PWY-7761:t:NAD salvage pathway II (PNC IV cycle)", "R-DRE-196843:r:Vitamin B2 (riboflavin) metabolism", "R-RNO-196843:r:Vitamin B2 (riboflavin) metabolism", "R-HSA-196843:r:Vitamin B2 (riboflavin) metabolism", "R-CEL-196843:r:Vitamin B2 (riboflavin) metabolism", "R-MMU-196843:r:Vitamin B2 (riboflavin) metabolism"], "type": "Domain"}, "IPR056597": {"description": "LRRK2, ARM repeat domain", "go_ids": [], "go_terms": [], "name": "ARM_LRRK2", "pathway_ids": ["R-MMU-8857538", "R-HSA-8857538"], "pathways": ["R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Domain"}, "IPR056598": {"description": "FK506-binding protein 15-like domain", "go_ids": [], "go_terms": [], "name": "FKBP-15_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056599": {"description": "AAA+ ATPase lid domain, fungi", "go_ids": [], "go_terms": [], "name": "AAA_lid_fung", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056600": {"description": "T9SS-like, galactose binding domain-like", "go_ids": [], "go_terms": [], "name": "GBD_T9SS_assoc", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056601": {"description": "Galaxin-like repeats domain", "go_ids": [], "go_terms": [], "name": "Galaxin_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056602": {"description": "LRRK2, beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_LRRK2", "pathway_ids": ["R-MMU-8857538", "R-HSA-8857538"], "pathways": ["R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization"], "type": "Domain"}, "IPR056603": {"description": "GATOR1 complex protein NPRL3, C-terminal HTH domain", "go_ids": [], "go_terms": [], "name": "HTH_NPRL3", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR056604": {"description": "GBF1-like, tetratricopeptide repeats domain", "go_ids": [], "go_terms": [], "name": "GBF1-like_TPR", "pathway_ids": ["R-SPO-6807878", "R-SPO-199992", "R-CEL-199992", "R-SCE-6807878", "R-MMU-5620916", "R-SCE-6811434", "R-HSA-6807878", "R-CEL-6807878", "R-MMU-6807878", "R-HSA-199992", "R-HSA-5620916", "R-HSA-6811434", "R-SPO-6811438", "R-SPO-5620916", "R-HSA-9918476", "R-SPO-6811434", "R-SCE-6811438", "R-MMU-199992", "R-CEL-5620916", "R-SCE-5620916", "R-HSA-9918481", "R-CEL-6811434", "R-SCE-199992", "R-MMU-6811434"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-SPO-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-199992:r:trans-Golgi Network Vesicle Budding", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-HSA-199992:r:trans-Golgi Network Vesicle Budding", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SPO-6811438:r:Intra-Golgi traffic", "R-SPO-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9918476:r:Assembly and Release of Dengue Virus Virions", "R-SPO-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-6811438:r:Intra-Golgi traffic", "R-MMU-199992:r:trans-Golgi Network Vesicle Budding", "R-CEL-5620916:r:VxPx cargo-targeting to cilium", "R-SCE-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-CEL-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-SCE-199992:r:trans-Golgi Network Vesicle Budding", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR056605": {"description": "LTI65/LTI78, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LTI65_LTI78_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056606": {"description": "Elapor1/2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Elapor1/2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056607": {"description": "Elapor1/2, mannose 6-phosphate receptor homology domain", "go_ids": [], "go_terms": [], "name": "Elapor1/2_MRH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056608": {"description": "Elapor1/2, galactose binding domain", "go_ids": [], "go_terms": [], "name": "Elapor1/2_GBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056609": {"description": "Elapor1-like, galactose binding domain", "go_ids": [], "go_terms": [], "name": "Elapor1-like_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056610": {"description": "Elapor1/2, TNF receptor-like", "go_ids": [], "go_terms": [], "name": "Elapor1/2_TNFR-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056611": {"description": "Ecto-NOX disulfide-thiol exchanger 1/2 domain", "go_ids": [], "go_terms": [], "name": "ENOX1/2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056612": {"description": "Fibulin-2 domain", "go_ids": [], "go_terms": [], "name": "FIBL-2_dom", "pathway_ids": ["R-MMU-2129379", "R-HSA-2129379"], "pathways": ["R-MMU-2129379:r:Molecules associated with elastic fibres", "R-HSA-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR056613": {"description": "Protein of unknown function DUF7287", "go_ids": [], "go_terms": [], "name": "DUF7287", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056614": {"description": "Flagellar attachment zone protein 1, conserved domain", "go_ids": [], "go_terms": [], "name": "FAZ1_cons", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056615": {"description": "FAZ1, C-terminal region", "go_ids": [], "go_terms": [], "name": "FAZ1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056616": {"description": "MIT1, chromo domain", "go_ids": [], "go_terms": [], "name": "Chromo_MIT1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056617": {"description": "Microtubule-associated protein 1B/S, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MAP1B/S_N", "pathway_ids": ["R-HSA-9833110"], "pathways": ["R-HSA-9833110:r:RSV-host interactions"], "type": "Domain"}, "IPR056618": {"description": "Membrane-bound transcription factor PTM, chromo domain-like", "go_ids": [], "go_terms": [], "name": "Chromo_PTM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056619": {"description": "Mucin-4-like, C8-3 domain", "go_ids": [], "go_terms": [], "name": "C8-3_MUC4", "pathway_ids": ["R-DME-977068", "R-HSA-5083632", "R-HSA-5083636", "R-RNO-977068", "R-MMU-913709", "R-HSA-977068", "R-HSA-5083625", "R-CEL-913709", "R-MMU-977068", "R-RNO-913709", "R-DME-913709", "R-HSA-5621480", "R-HSA-913709"], "pathways": ["R-DME-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-RNO-977068:r:Termination of O-glycan biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", 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"go_terms": [], "name": "SUS_N", "pathway_ids": ["PWY-3801"], "pathways": ["PWY-3801:t:sucrose degradation II (sucrose synthase)"], "type": "Domain"}, "IPR056736": {"description": "Sucrose synthase, EPBD domain", "go_ids": [], "go_terms": [], "name": "SUS_EPBD", "pathway_ids": ["PWY-3801"], "pathways": ["PWY-3801:t:sucrose degradation II (sucrose synthase)"], "type": "Domain"}, "IPR056737": {"description": "Attractin/MKLN-like, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_ATRN-MKLN-like", "pathway_ids": ["R-DDI-354192", "R-DDI-381676", "R-DDI-171007", "R-HSA-8951664", "R-MMU-9861718", "R-DDI-392517", "R-SCE-6798695", "R-DDI-9013423", "R-DDI-5673001", "R-HSA-983168", "R-RNO-9861718", "R-DDI-1169092", "R-DDI-9013149", "R-HSA-9861718", "R-DDI-193648"], "pathways": ["R-DDI-354192:r:Integrin signaling", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DDI-171007:r:p38MAPK events", "R-HSA-8951664:r:Neddylation", "R-MMU-9861718:r:Regulation of pyruvate metabolism", "R-DDI-392517:r:Rap1 signalling", "R-SCE-6798695:r:Neutrophil degranulation", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-9861718:r:Regulation of pyruvate metabolism", "R-DDI-1169092:r:Activation of RAS in B cells", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-HSA-9861718:r:Regulation of pyruvate metabolism", "R-DDI-193648:r:NRAGE signals death through JNK"], "type": "Domain"}, "IPR056738": {"description": "NfeD1b, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NfeD1b_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056739": {"description": "NfeD, integral membrane domain", "go_ids": [], "go_terms": [], "name": "NfeD_membrane", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056740": {"description": "Dihydroxy-acid/6-phosphogluconate dehydratase, C-terminal", "go_ids": [], "go_terms": [], "name": "ILV_EDD_C", "pathway_ids": ["PWY-7111", "PWY-5101", "PWY-5103", "PWY-5104"], "pathways": ["PWY-7111:t:pyruvate fermentation to isobutanol (engineered)", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-5103:t:L-isoleucine biosynthesis III", "PWY-5104:t:L-isoleucine biosynthesis IV"], "type": "Domain"}, "IPR056741": {"description": "Bridge-like lipid transfer protein family member 1, middle region", "go_ids": [], "go_terms": [], "name": "BLTP1_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056742": {"description": "Bridge-like lipid transfer protein family member 1, C-terminal", "go_ids": [], "go_terms": [], "name": "BLTP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056743": {"description": "TRM5/TYW2-like, methyltransferase domain", "go_ids": [], "go_terms": [], "name": "TRM5-TYW2-like_MTfase", "pathway_ids": ["PWY-7286", "PWY-7285", "PWY-6829", "R-HSA-6782861"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)"], "type": "Domain"}, "IPR056744": {"description": "TRM5/TYW2-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TRM5/TYW2-like_N", "pathway_ids": ["PWY-7286", "PWY-7285", "PWY-6829", "R-HSA-6782861"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-6829:t:tRNA methylation (yeast)", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)"], "type": "Domain"}, "IPR056745": {"description": "TYW2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TYW2_N", "pathway_ids": ["PWY-7286", "R-HSA-6782861"], "pathways": ["PWY-7286:t:7-(3-amino-3-carboxypropyl)-wyosine biosynthesis", "R-HSA-6782861:r:Synthesis of wybutosine at G37 of tRNA(Phe)"], "type": "Domain"}, "IPR056746": {"description": "Surface presentation of antigen domain", "go_ids": [], "go_terms": [], "name": "SPAN_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056747": {"description": "VPS13-like, middle region", "go_ids": [], "go_terms": [], "name": "VPS13-like_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056748": {"description": "Intermembrane lipid transfer protein VPS13-like, C-terminal", "go_ids": [], "go_terms": [], "name": "VPS13-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056749": {"description": "ATP-citrate synthase, ATP-grasp domain", "go_ids": [], "go_terms": [], "name": "Citrate_synth_N", "pathway_ids": ["PWY-5172", "R-HSA-163765", "R-HSA-6798695", "R-BTA-75105", "R-HSA-75105", "R-CEL-6798695", "R-MMU-6798695", "R-BTA-6798695", "R-RNO-75105", "R-MMU-75105", "R-RNO-6798695", "R-CEL-75105"], "pathways": ["PWY-5172:t:acetyl-CoA biosynthesis from citrate", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-6798695:r:Neutrophil degranulation", "R-CEL-75105:r:Fatty acyl-CoA biosynthesis"], "type": "Domain"}, "IPR056750": {"description": "ESF1, RRM domain", "go_ids": [], "go_terms": [], "name": "RRM_ESF1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056751": {"description": "ERT1/acuK family, PAS domain", "go_ids": [], "go_terms": [], "name": "PAS_13", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056752": {"description": "Elongation factor-like GTPase 1 domain", "go_ids": [], "go_terms": [], "name": "EFL1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056753": {"description": "DrmE-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DrmE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056754": {"description": "DSCAM/DSCAML, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DSCAM/DSCAML_C", "pathway_ids": ["R-MMU-376172", "R-RNO-376172", "R-DME-376172", "R-HSA-376172"], "pathways": ["R-MMU-376172:r:DSCAM interactions", "R-RNO-376172:r:DSCAM interactions", "R-DME-376172:r:DSCAM interactions", "R-HSA-376172:r:DSCAM interactions"], "type": "Domain"}, "IPR056755": {"description": "dsRNA binding domain", "go_ids": [], "go_terms": [], "name": "DSRM_2", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR056756": {"description": "DUF2110, central domain", "go_ids": [], "go_terms": [], "name": "DUF2110_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056757": {"description": "DUF2110, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF2110_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056758": {"description": "DUF2110, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF2110_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056759": {"description": "Dynein axonemal heavy chain 2/5/8, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "DYH2-5-8_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056760": {"description": "E3 ubiquitin-protein ligase XB3-like, RING finger", "go_ids": [], "go_terms": [], "name": "RING_XB3-like", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR056761": {"description": "E3 UFM1-protein ligase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ufl1-like_C", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7887", "PWY-6841", "R-BTA-983168", "R-DDI-983168", "R-DME-983168", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-MMU-983168", "R-DRE-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR056762": {"description": "Tumor necrosis factor receptor superfamily member EDAR, death domain", "go_ids": [], "go_terms": [], "name": "Death_EDAR", "pathway_ids": ["R-HSA-5669034", "R-MMU-5669034"], "pathways": ["R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Domain"}, "IPR056764": {"description": "EIF2B subunit epsilon/gamma, LbH domain", "go_ids": [], "go_terms": [], "name": "LbH_EIF2B3/5", "pathway_ids": ["R-SCE-72731", "R-SPO-72731", "R-RNO-72731", "R-HSA-72731", "R-CEL-72731", "R-MMU-72731", "R-DDI-72731"], "pathways": ["R-SCE-72731:r:Recycling of eIF2:GDP", "R-SPO-72731:r:Recycling of eIF2:GDP", "R-RNO-72731:r:Recycling of eIF2:GDP", "R-HSA-72731:r:Recycling of eIF2:GDP", "R-CEL-72731:r:Recycling of eIF2:GDP", "R-MMU-72731:r:Recycling of eIF2:GDP", "R-DDI-72731:r:Recycling of eIF2:GDP"], "type": "Domain"}, "IPR056767": {"description": "KIN17, C2H2-type zinc finger domain", "go_ids": [], "go_terms": [], "name": "C2H2-Znf_KIN17", "pathway_ids": ["R-HSA-8876725", "R-MMU-8876725"], "pathways": ["R-HSA-8876725:r:Protein methylation", "R-MMU-8876725:r:Protein methylation"], "type": "Domain"}, "IPR056768": {"description": "Piezo, transmembrane helical unit", "go_ids": [], "go_terms": [], "name": "THU_Piezo", "pathway_ids": ["R-HSA-9860927", "R-HSA-9856532", "R-HSA-9856530"], "pathways": ["R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Domain"}, "IPR056769": {"description": "Piezo, TM1-24", "go_ids": [], "go_terms": [], "name": "Piezo_TM1-24", "pathway_ids": ["R-HSA-9860927", "R-HSA-9856532", "R-HSA-9856530"], "pathways": ["R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Domain"}, "IPR056770": {"description": "Piezo, THU9 and anchor domain", "go_ids": [], "go_terms": [], "name": "Piezo_THU9_anchor", "pathway_ids": ["R-HSA-9860927", "R-HSA-9856532", "R-HSA-9856530"], "pathways": ["R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Domain"}, "IPR056771": {"description": "FHOD1/3-like, FH3 domain", "go_ids": [], "go_terms": [], "name": "FH3_FHOD1-3-like", "pathway_ids": ["R-DDI-8849471"], "pathways": ["R-DDI-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "type": "Domain"}, "IPR056772": {"description": "Origin recognition complex subunit 2, RecA-like domain", "go_ids": [], "go_terms": [], "name": "RecA-like_ORC2", "pathway_ids": ["R-DDI-68689", "R-RNO-68949", "R-HSA-68949", "R-SPO-68616", "R-RNO-68962", "R-CEL-68962", "R-HSA-113507", "R-MMU-68949", "R-RNO-176187", "R-HSA-68616", "R-DME-68962", "R-DDI-68962", "R-RNO-68616", "R-HSA-68962", "R-SCE-176187", "R-CEL-68616", "R-HSA-176187", "R-DME-68949", "R-RNO-68689", "R-DDI-68616", "R-DME-176187", "R-HSA-68867", "R-SPO-176187", "R-MMU-68962", "R-HSA-68689", "R-SCE-68962", "R-DME-68616", "R-SCE-68616", "R-DME-68689", "R-CEL-68949", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-CEL-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-68949:r:Orc1 removal from chromatin", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin"], "type": "Domain"}, "IPR056773": {"description": "Origin recognition complex subunit 2, winged-helix domain", "go_ids": [], "go_terms": [], "name": "WHD_ORC2", "pathway_ids": ["R-DDI-68689", "R-RNO-68949", "R-HSA-68949", "R-SPO-68616", "R-RNO-68962", "R-CEL-68962", "R-HSA-113507", "R-MMU-68949", "R-RNO-176187", "R-HSA-68616", "R-DME-68962", "R-DDI-68962", "R-RNO-68616", "R-HSA-68962", "R-SCE-176187", "R-CEL-68616", "R-HSA-176187", "R-DME-68949", "R-RNO-68689", "R-DDI-68616", "R-DME-176187", "R-HSA-68867", "R-SPO-176187", "R-MMU-68962", "R-HSA-68689", "R-SCE-68962", "R-DME-68616", "R-SCE-68616", "R-DME-68689", "R-CEL-68949", "R-SPO-68689", "R-SCE-68689", "R-DDI-68949", "R-MMU-176187", "R-SPO-68962", "R-MMU-68689", "R-MMU-68616", "R-SPO-68949"], "pathways": ["R-DDI-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68949:r:Orc1 removal from chromatin", "R-HSA-68949:r:Orc1 removal from chromatin", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-SCE-176187:r:Activation of ATR in response to replication stress", "R-CEL-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-DME-68949:r:Orc1 removal from chromatin", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-SPO-176187:r:Activation of ATR in response to replication stress", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-SCE-68616:r:Assembly of the ORC complex at the origin of replication", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-CEL-68949:r:Orc1 removal from chromatin", "R-SPO-68689:r:CDC6 association with the ORC:origin complex", "R-SCE-68689:r:CDC6 association with the ORC:origin complex", "R-DDI-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-SPO-68949:r:Orc1 removal from chromatin"], "type": "Domain"}, "IPR056774": {"description": "FdhE, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FdhE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056775": {"description": "YABBY protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YABBY_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056776": {"description": "YABBY, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YABBY_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056777": {"description": "Ycf2, N-terminal", "go_ids": [], "go_terms": [], "name": "Ycf2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056778": {"description": "UPF0261, C-terminal domain", "go_ids": [], "go_terms": [], "name": "UPF0261_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056779": {"description": "Csf1, C-terminal region", "go_ids": [], "go_terms": [], "name": "Csf1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056780": {"description": "Renin receptor-like, C-terminal transmembrane spanning segment", "go_ids": [], "go_terms": [], "name": "Renin_r_C", "pathway_ids": ["R-HSA-6798695", "R-BTA-2022377", "R-DME-6798695", "R-MMU-6798695", "R-DME-2022377", "R-BTA-6798695", "R-RNO-2022377", "R-HSA-2022377", "R-RNO-6798695", "R-MMU-2022377"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Domain"}, "IPR056782": {"description": "Polynucleotide kinase, PNKP phosphatase domain", "go_ids": [], "go_terms": [], "name": "HAD_PNKP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056783": {"description": "DNA replication complex GINS protein PSF1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PSF1_C", "pathway_ids": ["R-BTA-176974", "R-SCE-176974", "R-SPO-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-CEL-176974"], "pathways": ["R-BTA-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-CEL-176974:r:Unwinding of DNA"], "type": "Domain"}, "IPR056784": {"description": "DNA replication complex GINS protein PSF2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PSF2_N", "pathway_ids": ["R-CEL-176974", "R-DME-176974", "R-SPO-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974"], "pathways": ["R-CEL-176974:r:Unwinding of DNA", "R-DME-176974:r:Unwinding of DNA", "R-SPO-176974:r:Unwinding of DNA", "R-DDI-176974:r:Unwinding of DNA", "R-HSA-176974:r:Unwinding of DNA", "R-MMU-176974:r:Unwinding of DNA", "R-SCE-176974:r:Unwinding of DNA"], "type": "Domain"}, "IPR056785": {"description": "Putative mannosyltransferase YkcA/B-like, C-terminal", "go_ids": [], "go_terms": [], "name": "YkcA/B-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056787": {"description": "3'-5' exoribonuclease HELZ2, OB-fold domain", "go_ids": [], "go_terms": [], "name": "OB_HELZ2", "pathway_ids": ["R-HSA-1989781", "R-HSA-2151201", "R-HSA-9933387", "R-HSA-9707564", "R-HSA-381340", "R-HSA-400206", "R-HSA-9707616", "R-HSA-9931509", "R-HSA-1368108", "R-MMU-400206", "R-MMU-9707564", "R-HSA-2426168"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9707616:r:Heme signaling", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)"], "type": "Domain"}, "IPR056788": {"description": "ABC transporter A family member 2/9/11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ABCA2/9/11_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056789": {"description": "R13L1/DRL21-like, LRR repeat region", "go_ids": [], "go_terms": [], "name": "LRR_R13L1-DRL21", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056790": {"description": "Ribophorin II, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ribophorin_II_C", "pathway_ids": ["R-HSA-1799339", "R-RNO-9931295", "R-CFA-9768727", "R-MMU-9931295", "R-HSA-446203", "R-RNO-9768727", "R-HSA-9694548", "R-HSA-9918432", "R-CFA-9931295", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-9931295"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-RNO-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-446203:r:Asparagine N-linked glycosylation", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9694548:r:Maturation of spike protein", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CFA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9931295:r:PD-L1(CD274) glycosylation and translocation to plasma membrane"], "type": "Domain"}, "IPR056791": {"description": "Mcm10, C-terminal zinc binding motif", "go_ids": [], "go_terms": [], "name": "Znf_Mcm10_C", "pathway_ids": ["R-DME-68962", "R-DME-176187", "R-DRE-68962", "R-HSA-176187", "R-MMU-68962", "R-MMU-176187", "R-HSA-68962"], "pathways": ["R-DME-68962:r:Activation of the pre-replicative complex", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DRE-68962:r:Activation of the pre-replicative complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex"], "type": "Domain"}, "IPR056792": {"description": "Ribosome maturation factor RimM, PRC barrel domain", "go_ids": [], "go_terms": [], "name": "PRC_RimM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056793": {"description": "Heparan sulfate-N-deacetylase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HSNSD_N", "pathway_ids": ["PWY-6558", "R-MMU-2022928", "R-HSA-2022928", "R-CEL-2022928", "R-DME-2022928", "R-RNO-2022928"], "pathways": ["PWY-6558:t:heparan sulfate biosynthesis", "R-MMU-2022928:r:HS-GAG biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-CEL-2022928:r:HS-GAG biosynthesis", "R-DME-2022928:r:HS-GAG biosynthesis", "R-RNO-2022928:r:HS-GAG biosynthesis"], "type": "Domain"}, "IPR056794": {"description": "Patellin-1-6, C-terminal GOLD domain", "go_ids": [], "go_terms": [], "name": "PATL1-6_C_GOLD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056795": {"description": "PAC1-like, LisH-like dimerisation domain", "go_ids": [], "go_terms": [], "name": "PAC1-like_LisH-like_dom", "pathway_ids": ["R-GGA-380284", "R-DRE-1169091", "R-MMU-2467813", "R-DME-8951664", "R-DRE-8951664", "R-GGA-2565942", "R-HSA-380284", "R-MMU-68877", "R-DRE-2467813", "R-DRE-141444", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380320", "R-RNO-380320", "R-XTR-141444", "R-HSA-380320", "R-GGA-9648025", "R-RNO-380284", "R-DME-5676590", "R-GGA-5663220", "R-XTR-69601", "R-DRE-5663220", "R-MMU-5620912", "R-MMU-141444", "R-MMU-380259", "R-DRE-69601", "R-HSA-141444", "R-MMU-380270", "R-DRE-380320", "R-HSA-9648025", "R-GGA-5620912", "R-RNO-5663220", "R-XTR-380259", "R-XTR-380320", "R-MMU-6811436", "R-GGA-141444", "R-RNO-6811436", "R-DRE-5684264", "R-DME-69601", "R-MMU-8854518", "R-RNO-2467813", "R-DRE-5607761", "R-DME-5607764", "R-DME-2871837", "R-RNO-380270", "R-MMU-5663220", "R-RNO-141444", "R-DRE-6811436", "R-GGA-8854518", "R-DME-983168", "R-DME-202424", "R-DME-1169091", "R-HSA-2467813", "R-RNO-2500257", "R-XTR-2467813", "R-XTR-380270", "R-RNO-5620912", "R-DME-2565942", "R-MMU-380284", "R-CEL-983168", "R-GGA-2500257", "R-HSA-2565942", "R-DRE-983168", "R-XTR-5620912", "R-RNO-2565942", "R-HSA-68877", "R-DME-5607761", "R-DRE-5676590", "R-GGA-2467813", "R-HSA-5620912", "R-MMU-9648025", "R-GGA-380259", "R-HSA-6811436", "R-MMU-2500257", "R-XTR-9648025", "R-RNO-68877", "R-GGA-6811436", "R-HSA-2500257", "R-DME-6811436", "R-RNO-8854518", "R-GGA-380270", "R-DRE-2500257", "R-CEL-6811436", "R-XTR-5663220", "R-XTR-380284", "R-GGA-380320", "R-HSA-380270", "R-XTR-68877", "R-XTR-8951664", "R-RNO-380259", "R-CEL-69601", "R-XTR-983168", "R-DRE-2565942", "R-CEL-2565942", "R-XTR-2565942", "R-HSA-5663220", "R-RNO-9648025", "R-HSA-380259", "R-XTR-8854518", "R-XTR-2500257", "R-CEL-8951664"], "pathways": ["R-GGA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-1169091:r:Activation of NF-kappaB in B cells", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-DME-8951664:r:Neddylation", "R-DRE-8951664:r:Neddylation", "R-GGA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-68877:r:Mitotic Prometaphase", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-GGA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-5663220:r:RHO GTPases Activate Formins", "R-XTR-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-DRE-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5663220:r:RHO GTPases Activate Formins", "R-XTR-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-GGA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-RNO-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-RNO-2467813:r:Separation of Sister Chromatids", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-5663220:r:RHO GTPases Activate Formins", "R-RNO-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-DRE-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-GGA-8854518:r:AURKA Activation by TPX2", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DME-202424:r:Downstream TCR signaling", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-RNO-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-2467813:r:Separation of Sister Chromatids", "R-XTR-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-GGA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-68877:r:Mitotic Prometaphase", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-GGA-2467813:r:Separation of Sister Chromatids", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-GGA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-XTR-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-RNO-68877:r:Mitotic Prometaphase", "R-GGA-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-GGA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-6811436:r:COPI-independent Golgi-to-ER retrograde traffic", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-GGA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-68877:r:Mitotic Prometaphase", "R-XTR-8951664:r:Neddylation", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-XTR-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-CEL-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR056796": {"description": "FdhE, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FdhE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056797": {"description": "FdhE, central domain", "go_ids": [], "go_terms": [], "name": "FdhE_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056798": {"description": "Fe-containing alcohol dehydrogenase-like, C-terminal", "go_ids": [], "go_terms": [], "name": "ADH_Fe_C", "pathway_ids": ["R-CEL-880009", "R-DME-880009", "R-HSA-880009", "R-BTA-880009", "R-RNO-880009", "R-MMU-880009", "R-DDI-880009"], "pathways": ["R-CEL-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DME-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-HSA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-BTA-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-RNO-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-MMU-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate", "R-DDI-880009:r:Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "type": "Domain"}, "IPR056799": {"description": "Aegyptin/gSG7 salivary protein-like, four-helix bundle", "go_ids": [], "go_terms": [], "name": "ALL3/gSG7_salivary-like_helix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056800": {"description": "RNA-binding protein RO60, vWA domain", "go_ids": [], "go_terms": [], "name": "vWA_Ro60", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056801": {"description": "SBSPON-like, C-terminal", "go_ids": [], "go_terms": [], "name": "SBSPON_C", "pathway_ids": ["R-BTA-5173214", "R-HSA-5083635", "R-MMU-5173214", "R-HSA-5173214"], "pathways": ["R-BTA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS", "R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Domain"}, "IPR056802": {"description": "Serine/threonine-protein kinase ATR-like, M-HEAT region", "go_ids": [], "go_terms": [], "name": "ATR-like_M-HEAT", "pathway_ids": ["R-HSA-5693616", "R-DDI-6803207", "R-DDI-6804760", "R-SCE-2559586", "R-DDI-2559586", "R-MMU-6804756", "R-HSA-1221632", "R-HSA-6796648", "R-SPO-9664873", "R-SPO-6804756", "R-MMU-5685938", "R-DDI-5693565", "R-MMU-69473", "R-SCE-5693565", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-SCE-9664873", "R-DDI-6804756", "R-SCE-5693548", "R-DDI-5693607", "R-SPO-6803207", "R-HSA-176187", "R-HSA-5685938", "R-MMU-5693607", "R-DME-176187", "R-DDI-5693616", "R-HSA-69473", "R-DME-69473", "R-SPO-5693565", "R-HSA-6783310", "R-MMU-6783310", "R-HSA-6804756", "R-DDI-349425", "R-SPO-2559586", "R-DDI-9664873", "R-MMU-176187", "R-SPO-5693548", "R-DDI-5693548"], "pathways": ["R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DDI-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-DDI-6804760:r:Regulation of TP53 Activity through Methylation", "R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-9664873:r:Pexophagy", "R-SPO-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-DDI-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SCE-9664873:r:Pexophagy", "R-DDI-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DME-69473:r:G2/M DNA damage checkpoint", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-9664873:r:Pexophagy", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-DDI-5693548:r:Sensing of DNA Double Strand Breaks"], "type": "Domain"}, "IPR056803": {"description": "Serine/threonine-protein kinase ATR-like, N-HEAT region", "go_ids": [], "go_terms": [], "name": "ATR-like_N-HEAT", "pathway_ids": ["R-MMU-69473", "R-MMU-5685938", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-3371453", "R-HSA-6804756", "R-HSA-5693616", "R-HSA-69473", "R-MMU-176187", "R-HSA-5685938", "R-MMU-6804756", "R-HSA-1221632", "R-HSA-6796648", "R-HSA-176187", "R-HSA-6783310", "R-MMU-5693607", "R-MMU-6783310"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-MMU-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-1221632:r:Meiotic synapsis", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-6783310:r:Fanconi Anemia Pathway"], "type": "Domain"}, "IPR056804": {"description": "SESTD1-like, spectrin repeats region", "go_ids": [], "go_terms": [], "name": "Spectrin_SESTD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056805": {"description": "ACT domain-containing protein ACR9/10, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ACT_ACR9/10_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056806": {"description": "Stabilin-1/2, EGF-like domain", "go_ids": [], "go_terms": [], "name": "EGF_STAB1-2", "pathway_ids": ["R-MMU-3000497", "R-HSA-3000497", "R-HSA-2160916", "R-MMU-2160916", "R-MMU-2142845", "R-HSA-2142845"], "pathways": ["R-MMU-3000497:r:Scavenging by Class H Receptors", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-HSA-2160916:r:Hyaluronan degradation", "R-MMU-2160916:r:Hyaluronan degradation", "R-MMU-2142845:r:Hyaluronan metabolism", "R-HSA-2142845:r:Hyaluronan metabolism"], "type": "Domain"}, "IPR056807": {"description": "FHL1/2/3/5, N-terminal LIM domain", "go_ids": [], "go_terms": [], "name": "LIM_FHL1/2/3/5_N", "pathway_ids": ["R-HSA-1989781"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression"], "type": "Domain"}, "IPR056808": {"description": "AAA protein, C-terminal winged helix domain", "go_ids": [], "go_terms": [], "name": "HTH_AAA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056809": {"description": "GCN1-like, HEAT repeats", "go_ids": [], "go_terms": [], "name": "HEAT_GCN1_fung", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056810": {"description": "Stalled ribosome sensor GCN1-like, N-terminal", "go_ids": [], "go_terms": [], "name": "GNC1-like_N", "pathway_ids": ["R-HSA-9633012"], "pathways": ["R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR056812": {"description": "RNA-binding domain, fungi", "go_ids": [], "go_terms": [], "name": "RRM_fung", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056813": {"description": "GIL1/IRKI, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GIL1_IRKI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056814": {"description": "GIPC1-3, GH1 domain", "go_ids": [], "go_terms": [], "name": "GIPC1-3_GH1", "pathway_ids": ["R-RNO-9839397", "R-HSA-9839389", "R-RNO-190373", "R-MMU-190370", "R-MMU-9839389", "R-MMU-190373", "R-MMU-9839397", "R-HSA-190373", "R-RNO-9839389", "R-HSA-190370", "R-RNO-190370", "R-HSA-9839397"], "pathways": ["R-RNO-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-MMU-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-9839397:r:TGFBR3 regulates FGF2 signaling"], "type": "Domain"}, "IPR056816": {"description": "ACT domain-containing protein ACR9/10, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ACR9/10_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056818": {"description": "Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like, C-terminal hexapeptide", "go_ids": [], "go_terms": [], "name": "GlmU/GlgC-like_hexapep", "pathway_ids": ["PWY-7902", "PWY-622"], "pathways": ["PWY-7902:t:glucosylglycerol biosynthesis", "PWY-622:t:starch biosynthesis"], "type": "Domain"}, "IPR056819": {"description": "Acyl-CoA-binding domain-containing protein 4-6, C-terminal", "go_ids": [], "go_terms": [], "name": "ACBP4-6_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056820": {"description": "Teneurin, TTR-like domain", "go_ids": [], "go_terms": [], "name": "TEN_TTR-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056822": {"description": "Teneurin, NHL domain", "go_ids": [], "go_terms": [], "name": "TEN_NHL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056823": {"description": "Teneurin-like, YD-shell", "go_ids": [], "go_terms": [], "name": "TEN-like_YD-shell", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056824": {"description": "GPI inositol-deacylase, transmembrane domain", "go_ids": [], "go_terms": [], "name": "PGAP1_TMD", "pathway_ids": ["R-MMU-162791", "R-HSA-162791", "R-RNO-162791"], "pathways": ["R-MMU-162791:r:Attachment of GPI anchor to uPAR", "R-HSA-162791:r:Attachment of GPI anchor to uPAR", "R-RNO-162791:r:Attachment of GPI anchor to uPAR"], "type": "Domain"}, "IPR056825": {"description": "Agd3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Agd3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056826": {"description": "Agd3, deacetylase domain", "go_ids": [], "go_terms": [], "name": "Agd3_CE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056827": {"description": "Agd3, CBM87", "go_ids": [], "go_terms": [], "name": "CBM87_Agd3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056828": {"description": "TEP-1, C-terminal beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_TEP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056829": {"description": "TEP-1, second beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_TEP1_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056832": {"description": "Tetratricopeptide repeat protein 21A/21B, second ARM domain", "go_ids": [], "go_terms": [], "name": "ARM_TT21_2nd", "pathway_ids": ["R-HSA-5610787", "R-HSA-5620924", "R-CEL-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-CEL-5610787"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR056833": {"description": "Tetratricopeptide repeat protein 21A/21B, N-terminal ARM repeat", "go_ids": [], "go_terms": [], "name": "ARM_TT21_N", "pathway_ids": ["R-HSA-5610787", "R-HSA-5620924", "R-CEL-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-CEL-5610787"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR056834": {"description": "Tetratricopeptide repeat protein 21A/21B, C-terminal ARM domain", "go_ids": [], "go_terms": [], "name": "ARM_TT21_C", "pathway_ids": ["R-HSA-5610787", "R-HSA-5620924", "R-CEL-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-CEL-5610787"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR056835": {"description": "Tetratricopeptide repeat protein 21A/21B, fifth ARM repeats domain", "go_ids": [], "go_terms": [], "name": "ARM_TT21_5th", "pathway_ids": ["R-HSA-5610787", "R-HSA-5620924", "R-CEL-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-CEL-5610787"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR056836": {"description": "Tetratricopeptide repeat protein 21A/21B, fourth ARM domain", "go_ids": [], "go_terms": [], "name": "ARM_TT21_4th", "pathway_ids": ["R-HSA-5610787", "R-HSA-5620924", "R-CEL-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-CEL-5610787"], "pathways": ["R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR056838": {"description": "IFT122, zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_IFT122", "pathway_ids": ["R-XTR-5610787", "R-MMU-5620924", "R-HSA-5610787", "R-HSA-5620924", "R-XTR-5620924", "R-MMU-5610787", "R-CEL-5620924", "R-CEL-5610787"], "pathways": ["R-XTR-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-XTR-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-CEL-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR056839": {"description": "AHK4/CRE1/WOL, first receiver domain", "go_ids": [], "go_terms": [], "name": "Receiver_AHK4/CRE1_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056840": {"description": "Importin-9, central HEAT repeats", "go_ids": [], "go_terms": [], "name": "HEAT_IPO9_central", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056841": {"description": "TNRC18/BAHCC1-like, SH3 domain", "go_ids": [], "go_terms": [], "name": "TNRC18_BAHCC1-like_SH3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056842": {"description": "tRNA (32-2'-O)-methyltransferase regulator THADA-like, C-terminal TPR repeats region", "go_ids": [], "go_terms": [], "name": "THADA-like_TPR_C", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR056843": {"description": "tRNA (32-2'-O)-methyltransferase regulator THADA-like, TPR repeats region", "go_ids": [], "go_terms": [], "name": "THADA-like_TPR", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR056844": {"description": "Integrin beta-like protein A-E, N-terminal", "go_ids": [], "go_terms": [], "name": "SibA-E_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056845": {"description": "Zer-1-like, leucine-rich repeats region", "go_ids": [], "go_terms": [], "name": "LRR_Zer-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056847": {"description": "Integrin beta-like protein A-E, second Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_SibA-E_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056849": {"description": "Integrin beta-like protein A-E, third Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_SibA-E_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056850": {"description": "UBP34/UBP24/USP9X/USP9Y-like, ARM repeat region", "go_ids": [], "go_terms": [], "name": "ARM_UBP34_24_USP9X_Y", "pathway_ids": ["R-MMU-2173795", "R-HSA-201681", "R-HSA-9013420", "R-DME-9033241", "R-HSA-5689880", "R-HSA-977225", "R-MMU-9013424", "R-DME-9758274", "R-MMU-201681", "R-DME-2173795", "R-DME-9013424", "R-MMU-8866652", "R-MMU-9033241", "R-HSA-9013424", "R-DME-8866652", "R-MMU-5689880", "R-DME-445989", "R-MMU-9013420", "R-HSA-8866652", "R-HSA-2173795", "R-HSA-9033241", "R-DME-5689880", "R-DME-9013420"], "pathways": ["R-MMU-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-201681:r:TCF dependent signaling in response to WNT", "R-HSA-9013420:r:RHOU GTPase cycle", "R-DME-9033241:r:Peroxisomal protein import", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-977225:r:Amyloid fiber formation", "R-MMU-9013424:r:RHOV GTPase cycle", "R-DME-9758274:r:Regulation of NF-kappa B signaling", "R-MMU-201681:r:TCF dependent signaling in response to WNT", "R-DME-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-DME-9013424:r:RHOV GTPase cycle", "R-MMU-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-9033241:r:Peroxisomal protein import", "R-HSA-9013424:r:RHOV GTPase cycle", "R-DME-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-8866652:r:Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "R-HSA-2173795:r:Downregulation of SMAD2/3:SMAD4 transcriptional activity", "R-HSA-9033241:r:Peroxisomal protein import", "R-DME-5689880:r:Ub-specific processing proteases", "R-DME-9013420:r:RHOU GTPase cycle"], "type": "Domain"}, "IPR056851": {"description": "Integrin beta-like protein A-E, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig_SibA-E", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056852": {"description": "A-kinase anchor protein 17A/B", "go_ids": [], "go_terms": [], "name": "AK17A/B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR056853": {"description": "Alkylglycerol monooxygenase, C-terminal", "go_ids": [], "go_terms": [], "name": "AGMP_C", "pathway_ids": ["R-DRE-75109", "R-HSA-75109", "R-MMU-75109", "R-CEL-75109", "R-XTR-75109", "R-RNO-75109"], "pathways": ["R-DRE-75109:r:Triglyceride biosynthesis", "R-HSA-75109:r:Triglyceride biosynthesis", "R-MMU-75109:r:Triglyceride biosynthesis", "R-CEL-75109:r:Triglyceride biosynthesis", "R-XTR-75109:r:Triglyceride biosynthesis", "R-RNO-75109:r:Triglyceride biosynthesis"], "type": "Domain"}, "IPR056854": {"description": "Allantoinase, composite domain", "go_ids": [], "go_terms": [], "name": "ALN_composite", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056855": {"description": "IQCH-like, ATP-grasp", "go_ids": [], "go_terms": [], "name": "ATP-grasp_IQCH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056856": {"description": "AP-5 complex subunit zeta-1, C-terminal TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_AP5Z1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056857": {"description": "AP-5 complex subunit zeta-1, N-terminal TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_AP5Z1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056858": {"description": "Vacuolar sorting receptor, thioredoxin-like domain", "go_ids": [], "go_terms": [], "name": "VSR_TRX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056860": {"description": "Laminin subunit beta-4-like, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "LAMB4_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056861": {"description": "Hemicentin-1-like, von Willebrand factor A domain", "go_ids": [], "go_terms": [], "name": "HMCN1-like_VWA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056862": {"description": "VWA7, N-terminal domain", "go_ids": [], "go_terms": [], "name": "VWA7_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056863": {"description": "Laminin/attractin/netrin-like, EGF domain", "go_ids": [], "go_terms": [], "name": "LMN_ATRN_NET-like_EGF", "pathway_ids": ["R-HSA-8874081", "R-HSA-3000157", "R-HSA-3000178", "R-HSA-3560783", "R-HSA-977225", "R-HSA-418886", "R-HSA-9918485", "R-HSA-9619665", "R-HSA-9856532", "R-HSA-418885", "R-HSA-3656237", "R-HSA-373760", "R-HSA-9638630", "R-HSA-3656253", "R-MMU-8874081", "R-HSA-2024096", "R-HSA-2022928", "R-HSA-9833110", "R-HSA-446107", "R-HSA-525793", "R-HSA-9918481", "R-HSA-381426", "R-HSA-1474228", "R-HSA-9925563", "R-HSA-2214320", "R-MMU-3000157", "R-HSA-216083", "R-HSA-428542", "R-HSA-9913351", "R-HSA-3000171", "R-HSA-1971475", "R-HSA-9694614", "R-HSA-373752", "R-HSA-6785807", "R-HSA-3560801", "R-HSA-9820960", "R-HSA-163125", "R-HSA-2022090", "R-MMU-9913351", "R-HSA-4420332", "R-HSA-418890", "R-HSA-8957275", "R-HSA-975634", "R-HSA-376172", "R-MMU-373752", "R-DME-373752"], "pathways": ["R-HSA-8874081:r:MET activates PTK2 signaling", "R-HSA-3000157:r:Laminin interactions", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-3560783:r:Defective B4GALT7 causes EDS, progeroid type", "R-HSA-977225:r:Amyloid fiber formation", "R-HSA-418886:r:Netrin mediated repulsion signals", "R-HSA-9918485:r:Dengue Virus Attachment and Entry", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-418885:r:DCC mediated attractive signaling", "R-HSA-3656237:r:Defective EXT2 causes exostoses 2", "R-HSA-373760:r:L1CAM interactions", "R-HSA-9638630:r:Attachment of bacteria to epithelial cells", "R-HSA-3656253:r:Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-HSA-2024096:r:HS-GAG degradation", "R-HSA-2022928:r:HS-GAG biosynthesis", "R-HSA-9833110:r:RSV-host interactions", "R-HSA-446107:r:Type I hemidesmosome assembly", "R-HSA-525793:r:Myogenesis", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-1474228:r:Degradation of the extracellular matrix", "R-HSA-9925563:r:Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-2214320:r:Anchoring fibril formation", "R-MMU-3000157:r:Laminin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-1971475:r:Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-9694614:r:Attachment and Entry", "R-HSA-373752:r:Netrin-1 signaling", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-HSA-3560801:r:Defective B3GAT3 causes JDSSDHD", "R-HSA-9820960:r:Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-163125:r:Post-translational modification: synthesis of GPI-anchored proteins", "R-HSA-2022090:r:Assembly of collagen fibrils and other multimeric structures", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-4420332:r:Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-418890:r:Role of second messengers in netrin-1 signaling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-HSA-975634:r:Retinoid metabolism and transport", "R-HSA-376172:r:DSCAM interactions", "R-MMU-373752:r:Netrin-1 signaling", "R-DME-373752:r:Netrin-1 signaling"], "type": "Domain"}, "IPR056864": {"description": "Large ribosomal subunit protein bL9m, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MRP-L9_N", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-RNO-5419276", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-RNO-9937383", "R-MMU-5389840", "R-HSA-5389840", "R-BTA-9937383", "R-RNO-5389840"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5419276:r:Mitochondrial translation termination", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-9937383:r:Mitochondrial ribosome-associated quality control", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-RNO-5389840:r:Mitochondrial translation elongation"], "type": "Domain"}, "IPR056865": {"description": "Serine/threonine-protein kinase WNK, CCTL2 domain", "go_ids": [], "go_terms": [], "name": "CCTL2_WNK", "pathway_ids": ["R-HSA-2672351"], "pathways": ["R-HSA-2672351:r:Stimuli-sensing channels"], "type": "Domain"}, "IPR056866": {"description": "WRKY19-like, zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_WRKY19", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056867": {"description": "Leucine-rich repeat domain", "go_ids": [], "go_terms": [], "name": "LRR_15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056868": {"description": "Lipocalin domain, nematodes", "go_ids": [], "go_terms": [], "name": "Lipocalin_dom_nem", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056869": {"description": "LRRD1, death domain", "go_ids": [], "go_terms": [], "name": "DD_LRRD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056870": {"description": "TTC3/DZIP3/RBM44-like, helical domain", "go_ids": [], "go_terms": [], "name": "TTC3/DZIP3/RBM44-like_helical", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR056871": {"description": "E3 ubiquitin-protein ligase TTC3, winged helix turn helix domain", "go_ids": [], "go_terms": [], "name": "WH_TTC3", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR056872": {"description": "TTC3/DZIP3-like, helical domain", "go_ids": [], "go_terms": [], "name": "TTC3/DZIP3-like_helical", "pathway_ids": ["PWY-7511", "R-HSA-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR056874": {"description": "PHD-type zinc finger, plants", "go_ids": [], "go_terms": [], "name": "PHD_dom_pln", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056875": {"description": "MCM8/REC, winged helix domain", "go_ids": [], "go_terms": [], "name": "MCM8/REC_WHD", "pathway_ids": ["R-RNO-68949", "R-RNO-68689", "R-GGA-68689", "R-RNO-68962", "R-HSA-68949", "R-HSA-176974", "R-XTR-68689", "R-XTR-68962", "R-MMU-68962", "R-HSA-113507", "R-BTA-68949", "R-MMU-68949", "R-RNO-176187", "R-HSA-68689", "R-HSA-176187", "R-BTA-68962", "R-BTA-176187", "R-DME-68962", "R-DME-68689", "R-XTR-68949", "R-GGA-68949", "R-MMU-176187", "R-HSA-68962", "R-MMU-68689", "R-BTA-68689", "R-DME-68949", "R-GGA-176187", "R-DME-176187", "R-GGA-68962"], "pathways": ["R-RNO-68949:r:Orc1 removal from chromatin", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-GGA-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-176974:r:Unwinding of DNA", "R-XTR-68689:r:CDC6 association with the ORC:origin complex", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-XTR-68949:r:Orc1 removal from chromatin", "R-GGA-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68949:r:Orc1 removal from chromatin", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-GGA-68962:r:Activation of the pre-replicative complex"], "type": "Domain"}, "IPR056876": {"description": "Mechanosensitive ion channel protein 2/3, C-terminal", "go_ids": [], "go_terms": [], "name": "Msl2-3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056877": {"description": "Mediator of RNA polymerase II transcription subunit 14, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Med14_C", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR056878": {"description": "Mediator of RNA polymerase II transcription subunit 14, RM5", "go_ids": [], "go_terms": [], "name": "RM5_Med14", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR056879": {"description": "Mediator of RNA polymerase II transcription subunit 14, RM3", "go_ids": [], "go_terms": [], "name": "RM3_Med14", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR056880": {"description": "MEIOB-like, N-terminal", "go_ids": [], "go_terms": [], "name": "OB_MEIOB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056881": {"description": "Meiotically up-regulated gene 62 protein-like, alpha-beta domain", "go_ids": [], "go_terms": [], "name": "Mug62_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056882": {"description": "MOM1, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "MOM1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056883": {"description": "Nephrocystin 3, helical domain", "go_ids": [], "go_terms": [], "name": "NPHP3_hel", "pathway_ids": ["R-MMU-5624138", "R-HSA-5624138", "R-DRE-5624138"], "pathways": ["R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium"], "type": "Domain"}, "IPR056884": {"description": "Nephrocystin 3-like, N-terminal", "go_ids": [], "go_terms": [], "name": "NPHP3-like_N", "pathway_ids": ["R-MMU-5624138", "R-HSA-5624138", "R-DRE-5624138"], "pathways": ["R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium"], "type": "Domain"}, "IPR056885": {"description": "Nephrocystin-3, TPR-repeats region", "go_ids": [], "go_terms": [], "name": "TPR_NPHP3", "pathway_ids": ["R-MMU-5624138", "R-HSA-5624138", "R-DRE-5624138"], "pathways": ["R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium"], "type": "Domain"}, "IPR056886": {"description": "Nephrocystin-3, alpha-beta domain", "go_ids": [], "go_terms": [], "name": "NPHP3_ab_dom", "pathway_ids": ["R-MMU-5624138", "R-HSA-5624138", "R-DRE-5624138"], "pathways": ["R-MMU-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium", "R-DRE-5624138:r:Trafficking of myristoylated proteins to the cilium"], "type": "Domain"}, "IPR056887": {"description": "Nesprin-1/2 domain", "go_ids": [], "go_terms": [], "name": "SYNE1/2_dom", "pathway_ids": ["R-HSA-1221632"], "pathways": ["R-HSA-1221632:r:Meiotic synapsis"], "type": "Domain"}, "IPR056888": {"description": "NET2A-D/KIP1-like, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "NET2A-D/KIP1-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056889": {"description": "NET2A-D/KIP1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NET2A-D/KIP1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056890": {"description": "ATP-dependent RNA helicase DHX29-like, UBA domain", "go_ids": [], "go_terms": [], "name": "UBA_DHX29-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056891": {"description": "NEW1, helical bundle domain", "go_ids": [], "go_terms": [], "name": "NEW1_HB", "pathway_ids": ["R-SCE-382556"], "pathways": ["R-SCE-382556:r:ABC-family proteins mediated transport"], "type": "Domain"}, "IPR056892": {"description": "AtTam37, zinc finger domain", "go_ids": [], "go_terms": [], "name": "Zf-AtTam37", "pathway_ids": [], "pathways": [], "type": "Domain"}, 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"R-HSA-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700:r:NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-2660826:r:Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "R-MMU-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-HSA-9831926:r:Nephron development", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-2691232:r:Constitutive Signaling by NOTCH1 HD Domain Mutants", "R-DME-9013423:r:RAC3 GTPase cycle", "R-DME-2979096:r:NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-DRE-9013423:r:RAC3 GTPase cycle"], "type": "Domain"}, "IPR056987": {"description": "ZMYND8, coiled-coil", "go_ids": [], "go_terms": [], "name": "ZMYND8_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056988": {"description": "Zinc beta-ribbon domain, plants", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_pln", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056989": {"description": "Protocadherin-15 domain", "go_ids": [], "go_terms": [], "name": "PCDH15_12th_dom", "pathway_ids": ["R-HSA-9662360", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR056990": {"description": "VIN3-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "VIN3-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056991": {"description": "Thrombospondin type-1 domain-containing protein 7A/ 7B, C-terminal TSP1 domain", "go_ids": [], "go_terms": [], "name": "TSP1_TSH7A-B_C", "pathway_ids": ["R-MMU-5173214", "R-HSA-5173214", "R-DRE-5173214", "R-HSA-5083635"], "pathways": ["R-MMU-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-DRE-5173214:r:O-glycosylation of TSR domain-containing proteins", "R-HSA-5083635:r:Defective B3GALTL causes PpS"], "type": "Domain"}, "IPR056992": {"description": "Argonaute protein hrde-1/Nuclear RNAi defective-3 protein-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HRDE1/NRDE-3-like_N", "pathway_ids": ["R-CEL-426486", "R-CEL-203927"], "pathways": ["R-CEL-426486:r:Small interfering RNA (siRNA) biogenesis", "R-CEL-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR056993": {"description": "Activating signal cointegrator 1, third domain", "go_ids": [], "go_terms": [], "name": "TRIP4_3rd_dom", "pathway_ids": ["R-MMU-9954716", "R-HSA-9954716"], "pathways": ["R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "type": "Domain"}, "IPR056994": {"description": "Activating signal cointegrator 1, N-terminal", "go_ids": [], "go_terms": [], "name": "TRI4_N", "pathway_ids": ["R-MMU-9954716", "R-HSA-9954716"], "pathways": ["R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "type": "Domain"}, "IPR056995": {"description": "Peroxisomal ATPase PEX6, fourth domain", "go_ids": [], "go_terms": [], "name": "PEX6_4th_dom", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR056996": {"description": "SLA1-like, PH domain-like", "go_ids": [], "go_terms": [], "name": "PH_SLA1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056997": {"description": "Arabinofuranosyltransferase D, third carbohydrate binding module", "go_ids": [], "go_terms": [], "name": "CBM_AftD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056998": {"description": "Asd-4/GZF3-like, helical region", "go_ids": [], "go_terms": [], "name": "Asd-4/GZF3_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR056999": {"description": "Phage zinc binding protein, tailed bacteriophages", "go_ids": [], "go_terms": [], "name": "Phage_zn_bind", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057000": {"description": "Smacovirus capsid protein", "go_ids": [], "go_terms": [], "name": "Smaco_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057001": {"description": "RYYR-CCHC domain", "go_ids": [], "go_terms": [], "name": "RYYR-CCHC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057002": {"description": "YdgV", "go_ids": [], "go_terms": [], "name": "YdgV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057003": {"description": "Phage tail termination protein, tailed bacteriophages", "go_ids": [], "go_terms": [], "name": "Phage_tail_terminator_2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057004": {"description": "Gp90-like protein, tailed bacteriophages", "go_ids": [], "go_terms": [], "name": "Gp90-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057005": {"description": "Phage tail assembly chaperone, tailed bacteriophages", "go_ids": [], "go_terms": [], "name": "Phage_TAC_17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057006": {"description": "Phage tail chaperone protein-like", "go_ids": [], "go_terms": [], "name": "Phage_TAC_19", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057007": {"description": "Type III Secretion system protein OrgC", "go_ids": [], "go_terms": [], "name": "OrgC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057008": {"description": "SpoVR-like, C-terminal", "go_ids": [], "go_terms": [], "name": "SpoVR-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057009": {"description": "Fimbrial adhesin MrpH, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MrpH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057010": {"description": "Fimbrial adhesin MrpH, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MrpH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057011": {"description": "ULTRAPETALA1/2, SAND domain", "go_ids": [], "go_terms": [], "name": "ULT1/2_SAND", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057012": {"description": "ULTRAPETALA1/2, zinc finger domain", "go_ids": [], "go_terms": [], "name": "ULT1/2_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057013": {"description": "EGF-like domain-containing protein ComC, LRR domain", "go_ids": [], "go_terms": [], "name": "LRR_ComC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057014": {"description": "EGF-like domain-containing protein ComC, first beta-sandwich", "go_ids": [], "go_terms": [], "name": "B-sand_ComC_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057015": {"description": "EGF-like domain-containing protein ComC, second beta-sandwich", "go_ids": [], "go_terms": [], "name": "B-sand_ComC_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057016": {"description": "Endo-beta-N-acetylglucosaminidase EndoS/F2-like, TIM-barrel domain", "go_ids": [], "go_terms": [], "name": "EndoS_F2-like_TIM-barrel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057017": {"description": "F54D1.6-like, C-terminal Sushi-like domain", "go_ids": [], "go_terms": [], "name": "F54D1_6-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057018": {"description": "F54D1.6-like, Ig-like domain", "go_ids": [], "go_terms": [], "name": "F54D1_6-like_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057019": {"description": "F54D1.6-like, second Ig-like domain", "go_ids": [], "go_terms": [], "name": "F54D1_6-like_Ig-like_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057020": {"description": "Follistatin-related protein 1, EF-hand domain pair", "go_ids": [], "go_terms": [], "name": "EF-hand_FSTL1", "pathway_ids": ["R-BTA-8957275", "R-RNO-381426", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-BTA-201451", "R-HSA-201451", "R-HSA-8957275", "R-MMU-201451", "R-RNO-201451", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-201451:r:Signaling by BMP", "R-HSA-201451:r:Signaling by BMP", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-201451:r:Signaling by BMP", "R-RNO-201451:r:Signaling by BMP", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR057021": {"description": "STRA8, bHLH domain", "go_ids": [], "go_terms": [], "name": "bHLH_STRA8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057022": {"description": "PF0610-like, rubredoxin-like zinc beta-ribbon, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PF0610-like_Zn_ribbon_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057023": {"description": "Swiss Army Knife protein, DSP-PTPase phosphatase domain", "go_ids": [], "go_terms": [], "name": "PTP-SAK", "pathway_ids": ["R-HSA-1660514", "R-SPO-1660514"], "pathways": ["R-HSA-1660514:r:Synthesis of PIPs at the Golgi membrane", "R-SPO-1660514:r:Synthesis of PIPs at the Golgi membrane"], "type": "Domain"}, "IPR057024": {"description": "FORGETTER1, first zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Znr_FGT1_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057025": {"description": "FORGETTER1, second zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Znr_FGT1_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057026": {"description": "C2H2-type zinc finger, ascomycetes", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_ascomycetes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057027": {"description": "Mitochondrial 15S rRNA processing factor CCM1-like, TPR repeats", "go_ids": [], "go_terms": [], "name": "CCM1-like_TPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057028": {"description": "Rho GTPase-activating protein 29/45, N-terminal", "go_ids": [], "go_terms": [], "name": "RHG29_45_N", "pathway_ids": ["R-HSA-6798695", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-9013149", "R-MMU-9013148", "R-RNO-9013148", "R-BTA-9013148", "R-HSA-9013149", "R-DRE-9013148", "R-HSA-8980692", "R-HSA-9013148", "R-DRE-9013149", "R-BTA-8980692", "R-MMU-6798695", "R-DRE-8980692", "R-MMU-9013149"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-BTA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-BTA-8980692:r:RHOA GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR057029": {"description": "Tetratricopeptide repeats, fungi 2", "go_ids": [], "go_terms": [], "name": "TPR_fung_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057030": {"description": "E3 ubiquitin-protein ligase listerin, tetratricopeptide repeats region", "go_ids": [], "go_terms": [], "name": "TPR_Rkr-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057031": {"description": "SFR19-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SFR19-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057032": {"description": "MBTPS1, fourth domain", "go_ids": [], "go_terms": [], "name": "MBTPS1_4th", "pathway_ids": ["R-HSA-1655829", "R-HSA-8963889", "R-RNO-8874177", "R-RNO-381033", "R-HSA-8874211", "R-MMU-8874211", "R-MMU-8957275", "R-RNO-8874211", "R-HSA-381033", "R-RNO-1655829", "R-RNO-381426", "R-MMU-8874177", "R-RNO-8957275", "R-HSA-8874177", "R-MMU-381426", "R-HSA-8957275", "R-MMU-381033", "R-MMU-1655829", "R-HSA-381426"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-RNO-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-HSA-8874211:r:CREB3 factors activate genes", "R-MMU-8874211:r:CREB3 factors activate genes", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-RNO-8874211:r:CREB3 factors activate genes", "R-HSA-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-HSA-8874177:r:ATF6B (ATF6-beta) activates chaperones", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-381033:r:ATF6 (ATF6-alpha) activates chaperones", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR057033": {"description": "Isoleucine--tRNA ligase, cytoplasmic, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "Ubiquitin_IARS1", "pathway_ids": ["R-MMU-9856649", "R-HSA-379716", "R-HSA-9856649", "R-HSA-2408522"], "pathways": ["R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-379716:r:Cytosolic tRNA aminoacylation", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-2408522:r:Selenoamino acid metabolism"], "type": "Domain"}, "IPR057034": {"description": "FNG domain", "go_ids": [], "go_terms": [], "name": "FNG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057035": {"description": "FmdE-like, treble clef zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-Tbcl_FmdE", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057036": {"description": "Endo-acting ulvan lyase, beta-trefoil domain", "go_ids": [], "go_terms": [], "name": "Beta-tre_PLH30", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057037": {"description": "TPR repeat domain, actinomycetes", "go_ids": [], "go_terms": [], "name": "TPR_rep_actino", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057038": {"description": "FBX41/ZN365, C2H2-type zinc finger", "go_ids": [], "go_terms": [], "name": "FBX41/ZN365_Znf-C2H2", "pathway_ids": ["R-MMU-8951664", "R-HSA-8951664", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-MMU-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR057039": {"description": "F-box protein At5g52880-like, ARM repeats region", "go_ids": [], "go_terms": [], "name": "At5g52880_ARM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057040": {"description": "FAKV Clamp protein", "go_ids": [], "go_terms": [], "name": "FAKV_Clamp", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057041": {"description": "SCAP, N-terminal", "go_ids": [], "go_terms": [], "name": "SCAP_N", "pathway_ids": ["R-HSA-1655829", "R-MMU-1655829", "R-HSA-9918432", "R-RNO-1655829"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9918432:r:Maturation of DENV proteins", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "type": "Domain"}, "IPR057042": {"description": "SCAP, beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_SCAP", "pathway_ids": ["R-HSA-1655829", "R-MMU-1655829", "R-HSA-9918432", "R-RNO-1655829"], "pathways": ["R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9918432:r:Maturation of DENV proteins", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "type": "Domain"}, "IPR057043": {"description": "PARP14, second type I KH domain", "go_ids": [], "go_terms": [], "name": "PARP14_KH_2", "pathway_ids": ["R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein"], "type": "Domain"}, "IPR057044": {"description": "PARP14, first type I KH domain", "go_ids": [], "go_terms": [], "name": "PARP14_KH_1", "pathway_ids": ["R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein"], "type": "Domain"}, "IPR057045": {"description": "PARP14, third type I KH domain", "go_ids": [], "go_terms": [], "name": "PARP14_KH_3", "pathway_ids": ["R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein"], "type": "Domain"}, "IPR057046": {"description": "PARP14, fourth type I KH domain", "go_ids": [], "go_terms": [], "name": "PARP14_KH_4", "pathway_ids": ["R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", 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{"description": "PAR14-like, first RRM domain", "go_ids": [], "go_terms": [], "name": "PARP14_RPM_1", "pathway_ids": ["R-HSA-196807", "R-HSA-983168", "R-HSA-9683610", "R-HSA-9694631", "R-MMU-983168"], "pathways": ["R-HSA-196807:r:Nicotinate metabolism", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR057053": {"description": "ZMYND11/ZMYD8, MYND zinc finger", "go_ids": [], "go_terms": [], "name": "MYND_ZMYND11_ZMYD8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057054": {"description": "ZMYND11, coiled-coil", "go_ids": [], "go_terms": [], "name": "ZMYND11_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057055": {"description": "PRTase associated wHTH domain", "go_ids": [], "go_terms": [], "name": "wHTH-PRTase_assoc", "pathway_ids": [], 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"R-CEL-114604:r:GPVI-mediated activation cascade", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-RNO-186763:r:Downstream signal transduction", "R-MMU-9026527:r:Activated NTRK2 signals through PLCG1"], "type": "Domain"}, "IPR057062": {"description": "Immunity protein TriTu", "go_ids": [], "go_terms": [], "name": "TriTu", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057063": {"description": "Inactive Sirtuin", "go_ids": [], "go_terms": [], "name": "iSirtuin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057066": {"description": "ILCR1, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_ILCR1", "pathway_ids": ["R-CEL-5674135"], "pathways": ["R-CEL-5674135:r:MAP2K and MAPK activation"], "type": "Domain"}, "IPR057067": {"description": "Partner of xrn-2 protein 1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Paxt-1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057068": {"description": "IML1, N-terminal domain, fungi", "go_ids": [], "go_terms": [], "name": "IML1_N_fung", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057069": {"description": "Immunoglobulin A1 protease autotransporter, domain 2", "go_ids": [], "go_terms": [], "name": "IgA0_D2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057070": {"description": "Inactive HKD-Rease", "go_ids": [], "go_terms": [], "name": "HKD_inactive", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057071": {"description": "INO2 bHLH domain", "go_ids": [], "go_terms": [], "name": "bHLH_INO2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057072": {"description": "INO4, bHLH domain", "go_ids": [], "go_terms": [], "name": "bHLH_INO4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057073": {"description": "Integrin beta, epidermal growth factor-like domain 2", "go_ids": [], "go_terms": [], "name": "EGF_integrin_2", "pathway_ids": ["R-DME-2173789", "R-HSA-8874081", "R-MMU-210991", "R-HSA-6802952", "R-RNO-372708", "R-HSA-3000178", "R-MMU-9013408", "R-MMU-210990", "R-CEL-3000178", "R-HSA-9856532", "R-MMU-445355", "R-CEL-1566948", "R-DME-445355", "R-MMU-3000170", "R-CEL-446343", "R-RNO-9634597", "R-RNO-210990", "R-DME-446343", "R-MMU-202733", "R-CEL-198933", "R-HSA-8875513", "R-CEL-3000170", "R-MMU-1566948", "R-HSA-6802955", "R-HSA-210991", "R-RNO-446343", "R-DME-9013149", "R-HSA-6802948", "R-DME-210991", "R-RNO-445144", "R-RNO-1566977", "R-BTA-1566948", "R-DME-114608", "R-MMU-9634597", "R-CEL-5674135", "R-HSA-9609690", "R-HSA-8941332", "R-HSA-447041", "R-DME-216083", "R-MMU-9013423", "R-MMU-216083", "R-HSA-445144", "R-MMU-354192", "R-MMU-9860927", "R-HSA-9656223", "R-HSA-9634597", "R-MMU-5674135", "R-RNO-216083", "R-RNO-9860927", "R-HSA-9013423", "R-RNO-8874081", "R-HSA-114608", "R-MMU-8874081", "R-RNO-354192", "R-CEL-354192", "R-RNO-5674135", "R-BTA-2129379", "R-RNO-2173789", "R-CEL-9013423", "R-MMU-3000157", "R-MMU-2173789", "R-HSA-2129379", "R-HSA-3000170", "R-MMU-1566977", "R-DME-202733", "R-DME-6798695", "R-DME-446107", "R-MMU-354194", "R-MMU-1236973", "R-RNO-9013423", "R-CEL-445355", "R-HSA-5663220", "R-MMU-9013149", "R-RNO-3000170", "R-BTA-216083", "R-HSA-202733", "R-HSA-6798695", "R-HSA-5674135", "R-HSA-166016", "R-DME-198933", "R-CEL-6798695", "R-CEL-354194", "R-BTA-6798695", "R-RNO-3000157", "R-RNO-9013149", "R-MMU-4420097", "R-MMU-9013404", "R-HSA-9927418", "R-BTA-2173789", "R-HSA-4420097", "R-MMU-3000178", "R-HSA-9649948", "R-HSA-446343", "R-RNO-202733", "R-CEL-202733", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-3000178", "R-HSA-2173789", "R-CEL-216083", "R-BTA-198933", "R-CEL-9860927", "R-RNO-198933", "R-CEL-1236973", "R-MMU-166016", "R-CEL-114608", "R-HSA-1236973", "R-MMU-445144", "R-HSA-6785807", "R-RNO-1566948", "R-DME-354192", "R-BTA-166016", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-75892", "R-MMU-198933", "R-DME-445144", "R-HSA-198933", "R-MMU-8875513", "R-MMU-6798695", "R-HSA-9860927", "R-HSA-372708", "R-RNO-4420097", "R-MMU-114608", "R-HSA-9725554", "R-HSA-3000157", "R-CEL-1566977", "R-BTA-3000178", "R-HSA-1566948", "R-DME-9860927", "R-RNO-354194", "R-RNO-2129379", "R-CEL-9013149", "R-RNO-114608", "R-BTA-202733", "R-MMU-372708", "R-HSA-210990", "R-RNO-8875513", "R-DME-1236973", "R-HSA-416700", "R-HSA-6802946", "R-DME-2129379", "R-HSA-9938206", "R-MMU-446343", "R-HSA-354192", "R-CEL-210991", "R-HSA-216083", "R-HSA-445355", "R-RNO-210991", "R-CEL-445144", "R-HSA-1566977", "R-HSA-9927432", "R-HSA-354194", "R-HSA-9679191", "R-HSA-9830674", "R-DME-3000170", "R-CEL-4420097", "R-DME-9013423", "R-MMU-2129379"], "pathways": ["R-DME-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-8874081:r:MET activates PTK2 signaling", "R-MMU-210991:r:Basigin interactions", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-RNO-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-3000178:r:ECM proteoglycans", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-210990:r:PECAM1 interactions", "R-CEL-3000178:r:ECM proteoglycans", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-MMU-445355:r:Smooth Muscle Contraction", "R-CEL-1566948:r:Elastic fibre formation", "R-DME-445355:r:Smooth Muscle Contraction", "R-MMU-3000170:r:Syndecan interactions", "R-CEL-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-9634597:r:GPER1 signaling", "R-RNO-210990:r:PECAM1 interactions", "R-DME-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-CEL-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-8875513:r:MET interacts with TNS proteins", "R-CEL-3000170:r:Syndecan interactions", "R-MMU-1566948:r:Elastic fibre formation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-210991:r:Basigin interactions", "R-RNO-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-DME-9013149:r:RAC1 GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-DME-210991:r:Basigin interactions", "R-RNO-445144:r:Signal transduction by L1", "R-RNO-1566977:r:Fibronectin matrix formation", "R-BTA-1566948:r:Elastic fibre formation", "R-DME-114608:r:Platelet degranulation", "R-MMU-9634597:r:GPER1 signaling", "R-CEL-5674135:r:MAP2K and MAPK activation", "R-HSA-9609690:r:HCMV Early Events", "R-HSA-8941332:r:RUNX2 regulates genes involved in cell migration", "R-HSA-447041:r:CHL1 interactions", "R-DME-216083:r:Integrin cell surface interactions", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-445144:r:Signal transduction by L1", "R-MMU-354192:r:Integrin signaling", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-HSA-9634597:r:GPER1 signaling", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-RNO-216083:r:Integrin cell surface interactions", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-RNO-8874081:r:MET activates PTK2 signaling", "R-HSA-114608:r:Platelet degranulation", "R-MMU-8874081:r:MET activates PTK2 signaling", "R-RNO-354192:r:Integrin signaling", "R-CEL-354192:r:Integrin signaling", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-BTA-2129379:r:Molecules associated with elastic fibres", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-9013423:r:RAC3 GTPase cycle", "R-MMU-3000157:r:Laminin interactions", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-2129379:r:Molecules associated with elastic fibres", "R-HSA-3000170:r:Syndecan interactions", "R-MMU-1566977:r:Fibronectin matrix formation", "R-DME-202733:r:Cell surface interactions at the vascular wall", "R-DME-6798695:r:Neutrophil degranulation", "R-DME-446107:r:Type I hemidesmosome assembly", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-CEL-445355:r:Smooth Muscle Contraction", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-3000170:r:Syndecan interactions", "R-BTA-216083:r:Integrin cell surface interactions", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-DME-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-6798695:r:Neutrophil degranulation", "R-CEL-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-3000157:r:Laminin interactions", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-BTA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-3000178:r:ECM proteoglycans", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-CEL-202733:r:Cell surface interactions at the vascular wall", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-3000178:r:ECM proteoglycans", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-CEL-216083:r:Integrin cell surface interactions", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-CEL-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-CEL-114608:r:Platelet degranulation", "R-HSA-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-MMU-445144:r:Signal transduction by L1", "R-HSA-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-RNO-1566948:r:Elastic fibre formation", "R-DME-354192:r:Integrin signaling", "R-BTA-166016:r:Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-DME-445144:r:Signal transduction by L1", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-8875513:r:MET interacts with TNS proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-114608:r:Platelet degranulation", "R-HSA-9725554:r:Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "R-HSA-3000157:r:Laminin interactions", "R-CEL-1566977:r:Fibronectin matrix formation", "R-BTA-3000178:r:ECM proteoglycans", "R-HSA-1566948:r:Elastic fibre formation", "R-DME-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-RNO-2129379:r:Molecules associated with elastic fibres", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-114608:r:Platelet degranulation", "R-BTA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-210990:r:PECAM1 interactions", "R-RNO-8875513:r:MET interacts with TNS proteins", "R-DME-1236973:r:Cross-presentation of particulate exogenous antigens (phagosomes)", "R-HSA-416700:r:Other semaphorin interactions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-DME-2129379:r:Molecules associated with elastic fibres", "R-HSA-9938206:r:Developmental Lineage of Mammary Stem Cells", "R-MMU-446343:r:Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "R-HSA-354192:r:Integrin signaling", "R-CEL-210991:r:Basigin interactions", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-445355:r:Smooth Muscle Contraction", "R-RNO-210991:r:Basigin interactions", "R-CEL-445144:r:Signal transduction by L1", "R-HSA-1566977:r:Fibronectin matrix formation", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9830674:r:Formation of the ureteric bud", "R-DME-3000170:r:Syndecan interactions", "R-CEL-4420097:r:VEGFA-VEGFR2 Pathway", "R-DME-9013423:r:RAC3 GTPase cycle", "R-MMU-2129379:r:Molecules associated with elastic fibres"], "type": "Domain"}, "IPR057074": {"description": "Ionotropic receptor 75a/84a, N-terminal", "go_ids": [], "go_terms": [], "name": "IR75A/84a_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057075": {"description": "Iron-related transcription factor 3, bHLH domain", "go_ids": [], "go_terms": [], "name": "bHLH_IRO3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057076": {"description": "HTH-like domain, caenorhabditis", "go_ids": [], "go_terms": [], "name": "HTH_71", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057077": {"description": "HTH-like domain 2, caenorhabditis", "go_ids": [], "go_terms": [], "name": "HTH_72", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057078": {"description": "HYR-like domain", "go_ids": [], "go_terms": [], "name": "HYR-4C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057079": {"description": "Type 4 adapter protein IcmW-like", "go_ids": [], "go_terms": [], "name": "IcmW-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057080": {"description": "SMP domain-containing protein, PH domain", "go_ids": [], "go_terms": [], "name": "PH_SMPa", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057081": {"description": "PH domain, N-terminal, fungi", "go_ids": [], "go_terms": [], "name": "PH_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057082": {"description": "PH domain, C-terminal, fungi", "go_ids": [], "go_terms": [], "name": "PH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057083": {"description": "Phage baseplate wedge subunit", "go_ids": [], "go_terms": [], "name": "Baseplate_wedge", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057084": {"description": "Phage integrase BP186-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Int_BP186-like_N", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR057085": {"description": "Irg-7-like, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_Irg-7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057086": {"description": "Irg-7, N-terminal galactose binding domain", "go_ids": [], "go_terms": [], "name": "GBD_Irg-7_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057087": {"description": "Phage neck terminator protein gp12-like", "go_ids": [], "go_terms": [], "name": "Gp12-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057088": {"description": "GLRG_09195, thioredoxin-like", "go_ids": [], "go_terms": [], "name": "GLRG_09195_Thiored", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057089": {"description": "T-cell immunomodulatory protein TIP, C2 domain", "go_ids": [], "go_terms": [], "name": "C2_TIP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057090": {"description": "Kinesin-like protein KIF26A/B, helical domain", "go_ids": [], "go_terms": [], "name": "HTH_KIF26A_B_1st", "pathway_ids": ["R-MMU-983189", "R-HSA-6811434", "R-HSA-2132295", "R-HSA-983189", "R-MMU-2132295", "R-MMU-6811434"], "pathways": ["R-MMU-983189:r:Kinesins", "R-HSA-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-2132295:r:MHC class II antigen presentation", "R-HSA-983189:r:Kinesins", "R-MMU-2132295:r:MHC class II antigen presentation", "R-MMU-6811434:r:COPI-dependent Golgi-to-ER retrograde traffic"], "type": "Domain"}, "IPR057091": {"description": "Kinetochore protein NDC80 loop 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"R-MMU-9954716", "R-RNO-9954716", "R-SCE-6791226", "R-CFA-72706", "R-DDI-9954714", "R-CEL-72706", "R-BTA-72695", "R-CEL-9954716", "R-CEL-9954714", "R-SCE-72702", "R-SSC-72706", "R-RNO-975957", "R-HSA-1799339", "R-SPO-975956", "R-MMU-6791226", "R-HSA-2408557", "R-BTA-156827", "R-MMU-9954714", "R-RNO-156827", "R-SPO-72706", "R-BTA-6791226", "R-SCE-975956", "R-DDI-72695", "R-CEL-1799339", "R-SSC-9954714", "R-BTA-72702", "R-HSA-72706", "R-HSA-9735869", "R-HSA-72702", "R-CEL-156827", "R-CFA-156827", "R-RNO-72649", "R-RNO-6791226", "R-SSC-1799339", "R-SSC-975957", "R-HSA-6791226", "R-RNO-975956", "R-SSC-72689", "R-CEL-72649", "R-SPO-156827", "R-DME-72702", "R-HSA-9954714", "R-BTA-72649", "R-SPO-72689", "R-CEL-72689", "R-CFA-9954714", "R-DDI-72689", "R-DDI-72702", "R-MMU-1799339", "R-SPO-72702", "R-HSA-9954716", "R-DDI-975956", "R-CFA-975957", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-DDI-6791226", "R-CEL-72702", "R-DME-72649", "R-HSA-156827", "R-CEL-72695", "R-RNO-72689", "R-MMU-72649", "R-HSA-192823", "R-SSC-72695", "R-SSC-9954716", "R-SSC-156827", "R-BTA-72706", "R-SCE-975957", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-SSC-72702", "R-CFA-72689", "R-SCE-72689", "R-SCE-72695", "R-MMU-72695", "R-MMU-975956", "R-CFA-9954716", "R-SCE-156827", "R-DME-975957", "R-DME-72695", "R-MMU-72702", "R-DME-975956", "R-BTA-9954716", "R-SPO-72649", "R-SPO-72695", "R-SSC-975956", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-RNO-72702", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-HSA-72649", "R-MMU-156827", "R-HSA-9754678", "R-SSC-72649", "R-BTA-1799339", "R-BTA-9954714", "R-SCE-72649", "R-HSA-975957", "R-DME-9954714", "R-CFA-975956", "R-BTA-975956", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-SPO-6791226", "R-DDI-156827", "R-CFA-72649", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-BTA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-975957:r:Nonsense Mediated 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pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR057261": {"description": "Sororin-like, middle region", "go_ids": [], "go_terms": [], "name": "Sororin-like_M", "pathway_ids": ["R-HSA-2468052", "R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-MMU-2468052", 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"R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR057266": {"description": "Large ribosomal subunit protein uL5, eukaryota/archaea", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL5_euk_arc", "pathway_ids": ["R-CEL-975957", "R-SPO-9954714", "R-HSA-9010553", "R-SCE-9954709", "R-SPO-975957", "R-RNO-1799339", "R-DME-9954716", "R-DME-72706", "R-MMU-72706", "R-HSA-975956", "R-CEL-975956", "R-MMU-9954716", "R-RNO-9954716", "R-DDI-9954714", "R-CEL-72706", "R-CEL-9954714", "R-CEL-9954716", "R-SPO-9954709", "R-RNO-975957", "R-SPO-975956", "R-HSA-1799339", "R-HSA-2408557", "R-MMU-6791226", "R-RNO-156827", "R-MMU-9954714", "R-SPO-72706", "R-SCE-975956", "R-CEL-1799339", "R-HSA-72706", "R-CEL-156827", "R-RNO-6791226", "R-HSA-6791226", "R-RNO-975956", "R-RNO-9954709", "R-SPO-156827", "R-HSA-9954714", "R-CEL-72689", "R-SPO-72689", "R-DDI-72689", "R-MMU-1799339", "R-DDI-975956", "R-HSA-9954716", "R-DME-9954709", "R-DME-156827", "R-SCE-72706", "R-MMU-72689", "R-HSA-156827", "R-RNO-72689", "R-MMU-9954709", "R-HSA-192823", "R-SCE-975957", "R-HSA-9954709", "R-DME-1799339", "R-SPO-1799339", "R-SCE-1799339", "R-DDI-9954716", "R-DDI-9954709", "R-SCE-72689", "R-MMU-975956", "R-SCE-156827", "R-DME-975956", "R-CEL-9954709", "R-MMU-975957", "R-DME-72689", "R-HSA-156902", "R-HSA-72689", "R-HSA-72764", "R-SCE-9954714", "R-MMU-156827", "R-HSA-975957", "R-DME-9954714", "R-DDI-72706", "R-DDI-975957", "R-DDI-1799339", "R-DME-975957", "R-DDI-156827", "R-RNO-72706", "R-RNO-9954714", "R-HSA-9633012"], "pathways": ["R-CEL-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-SCE-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-RNO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-HSA-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-MMU-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-RNO-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-SPO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-RNO-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-SPO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-2408557:r:Selenocysteine synthesis", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-SCE-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-CEL-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-RNO-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-RNO-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SPO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-72689:r:Formation of a pool of free 40S subunits", "R-SPO-72689:r:Formation of a pool of free 40S subunits", "R-DDI-72689:r:Formation of a pool of free 40S subunits", "R-MMU-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-HSA-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-SCE-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-192823:r:Viral mRNA Translation", "R-SCE-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SPO-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-SCE-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DDI-9954716:r:ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-SCE-72689:r:Formation of a pool of free 40S subunits", "R-MMU-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-SCE-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DME-975956:r:Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-72689:r:Formation of a pool of free 40S subunits", "R-HSA-156902:r:Peptide chain elongation", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-HSA-72764:r:Eukaryotic Translation Termination", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-HSA-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DDI-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DDI-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-DME-975957:r:Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Family"}, "IPR057267": {"description": "Large ribosomal subunit protein uL18, archaea", "go_ids": [], "go_terms": [], "name": "Rbsml_uL18_arc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057270": {"description": "Uncharacterized protein YcgB-like", "go_ids": [], "go_terms": [], "name": "Ycgb-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057271": {"description": "YagK/YfjJ, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YagK_YfjJ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057273": {"description": "Ddi1/2, HDD domain", "go_ids": [], "go_terms": [], "name": "Ddi1/2_HDD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057274": {"description": "Crescentin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CreS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057275": {"description": "GLAA-B, beta-barrel domain I", "go_ids": [], "go_terms": [], "name": "Beta-barrel_GLAA-B_I", "pathway_ids": ["PWY-6527"], "pathways": ["PWY-6527:t:stachyose degradation"], "type": "Domain"}, "IPR057276": {"description": "Thermus phage P23-45 gp39, N-terminal", "go_ids": [], "go_terms": [], "name": "P23-45_gp39_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057277": {"description": "Secreted LysM effector LysM, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LysM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057279": {"description": "MGAT4, conserved region", "go_ids": [], "go_terms": [], "name": "MGAT4", "pathway_ids": ["PWY-7426", "R-BTA-8957275", "R-RNO-381426", "R-HSA-381426", "R-RNO-975577", "R-DRE-975577", "R-RNO-8957275", "R-MMU-381426", "R-BTA-381426", "R-HSA-9694548", "R-BTA-975577", "R-HSA-975577", "R-HSA-8957275", "R-SSC-975577", "R-MMU-975577", "R-MMU-8957275"], "pathways": ["PWY-7426:t:complex N-linked glycan biosynthesis (vertebrates)", "R-BTA-8957275:r:Post-translational protein phosphorylation", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-975577:r:N-Glycan antennae elongation", "R-DRE-975577:r:N-Glycan antennae elongation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-BTA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-9694548:r:Maturation of spike protein", "R-BTA-975577:r:N-Glycan antennae elongation", "R-HSA-975577:r:N-Glycan antennae elongation", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-975577:r:N-Glycan antennae elongation", "R-MMU-975577:r:N-Glycan antennae elongation", "R-MMU-8957275:r:Post-translational protein phosphorylation"], "type": "Domain"}, "IPR057281": {"description": "REST-like, C2H2-type zinc finger", "go_ids": [], "go_terms": [], "name": "Zfn-C2H2_REST", "pathway_ids": ["R-MMU-3214815", "R-HSA-3214815", "R-HSA-9031628", "R-HSA-9679191", "R-HSA-9768777", "R-DRE-3214815", "R-HSA-8943724", "R-RNO-3214815"], "pathways": ["R-MMU-3214815:r:HDACs deacetylate histones", "R-HSA-3214815:r:HDACs deacetylate histones", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9768777:r:Regulation of NPAS4 gene transcription", "R-DRE-3214815:r:HDACs deacetylate histones", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-RNO-3214815:r:HDACs deacetylate histones"], "type": "Domain"}, "IPR057282": {"description": "RETREG1-3/ARL6IP-like, N-terminal reticulon-homology domain", "go_ids": [], "go_terms": [], "name": "RETREG1-3-like_RHD", "pathway_ids": ["R-HSA-9920951"], "pathways": ["R-HSA-9920951:r:Dengue virus modulates apoptosis"], "type": "Domain"}, "IPR057283": {"description": "RGF3, winged helix domain", "go_ids": [], "go_terms": [], "name": "RGF3_WH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057284": {"description": "Rho GTPase-activating protein 35-like, FF domain", "go_ids": [], "go_terms": [], "name": "FF_RHG35_4th", "pathway_ids": ["R-RNO-9013026", "R-HSA-9013409", "R-HSA-9013405", "R-CFA-9013409", "R-HSA-416550", "R-MMU-9013106", "R-RNO-9013409", "R-RNO-9696270", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-MMU-9013409", "R-CFA-9013404", "R-MMU-9013148", "R-HSA-9013106", "R-MMU-9013404", "R-RNO-416550", "R-CFA-9013149", "R-HSA-8849471", "R-HSA-9013423", "R-CFA-8849471", "R-DME-9035034", "R-DME-9013148", "R-CFA-9696264", "R-CFA-9013408", "R-HSA-9035034", "R-HSA-9013148", "R-DME-9013409", "R-DME-9013406", "R-RNO-9013408", "R-RNO-9013106", "R-RNO-9013406", "R-RNO-9013404", "R-CFA-9696270", "R-HSA-9013408", "R-MMU-8849471", "R-DME-350407", "R-MMU-9035034", "R-RNO-8849471", "R-CFA-9013406", "R-CFA-9013148", "R-DME-9013149", "R-CFA-8980692", "R-DME-8980692", "R-HSA-9696270", "R-CFA-416550", "R-RNO-9013148", "R-RNO-9696273", "R-CFA-9696273", "R-HSA-9696264", "R-RNO-9013423", "R-MMU-9013423", "R-HSA-9013404", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-416550", "R-CFA-9013106", "R-MMU-9013406", "R-MMU-9013026", "R-RNO-9696264", "R-HSA-9013026", "R-DME-8849471", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9013149", "R-DME-9013423", "R-HSA-9696273"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-CFA-9013409:r:RHOJ GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-MMU-9013106:r:RHOC GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-CFA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-RNO-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9013149:r:RAC1 GTPase cycle", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-CFA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-9035034:r:RHOF GTPase cycle", "R-DME-9013148:r:CDC42 GTPase cycle", "R-CFA-9696264:r:RND3 GTPase cycle", "R-CFA-9013408:r:RHOG GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DME-9013409:r:RHOJ GTPase cycle", "R-DME-9013406:r:RHOQ GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-CFA-9696270:r:RND2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-DME-350407:r:RHO1 GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-RNO-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-CFA-9013406:r:RHOQ GTPase cycle", "R-CFA-9013148:r:CDC42 GTPase cycle", "R-DME-9013149:r:RAC1 GTPase cycle", "R-CFA-8980692:r:RHOA GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-CFA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-9696273:r:RND1 GTPase cycle", "R-CFA-9696273:r:RND1 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-CFA-9013106:r:RHOC GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DME-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-DME-9013423:r:RAC3 GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR057285": {"description": "RNA cytosine-C(5)-methyltransferase NSUN2-like, pre-PUA domain", "go_ids": [], "go_terms": [], "name": "Pre-PUA_NSUN2", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-6782315"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR057286": {"description": "RNA cytosine-C(5)-methyltransferase NSUN2-like, PUA domain", "go_ids": [], "go_terms": [], "name": "PUA_NSUN2", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987", "R-HSA-6782315"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis", "R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR057287": {"description": "Nodulin homeobox, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ndx_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057288": {"description": "PLEKHM2, PH domain-like", "go_ids": [], "go_terms": [], "name": "PH_PLEKHM2", "pathway_ids": ["R-HSA-6798695", "R-HSA-9013149", "R-HSA-9696270", "R-MMU-9013149", "R-RNO-9696270", "R-RNO-9696264", "R-MMU-6798695", "R-RNO-9013149", "R-MMU-9696264", "R-MMU-9696270", "R-HSA-9696264"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-9696270:r:RND2 GTPase cycle", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle"], "type": "Domain"}, "IPR057290": {"description": "Cation/H(+) antiporter, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CHX17_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057291": {"description": "Cation/H(+) antiporter, central domain", "go_ids": [], "go_terms": [], "name": "CHX17_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057292": {"description": "Serine/threonine-protein kinase 11-interacting protein, PH domain", "go_ids": [], "go_terms": [], "name": "PH_S11IP", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR057293": {"description": "Ribonuclease R, second OB domain", "go_ids": [], "go_terms": [], "name": "RNR_OB2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057295": {"description": "Unkempt, zinc finger domain 4", "go_ids": [], "go_terms": [], "name": "UNK_Znf_4", "pathway_ids": ["R-DME-983168", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR057296": {"description": "Unkempt, zinc finger domain 5", "go_ids": [], "go_terms": [], "name": "UNK_Znf_5", "pathway_ids": ["R-DME-983168", "R-HSA-983168", "R-MMU-983168"], "pathways": ["R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR057297": {"description": "RNA-dependent RNA polymerase 6-like, second domain", "go_ids": [], "go_terms": [], "name": "RDR6-like_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057298": {"description": "RNA-dependent RNA polymerase 6-like, RNA-binding domain", "go_ids": [], "go_terms": [], "name": "RDR6-like_RBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057299": {"description": "RNF34/RFFL, SAP domain", "go_ids": [], "go_terms": [], "name": "RNF34_RFFL_SAP", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-RNO-6804757", "R-HSA-6804757", "R-MMU-6804757", "R-MMU-983168", "R-HSA-983168", "R-RNO-983168", "R-BTA-6804757"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-6804757:r:Regulation of TP53 Degradation"], "type": "Domain"}, "IPR057300": {"description": "Rrp5, OB-fold domain", "go_ids": [], "go_terms": [], "name": "OB_Rrp5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057301": {"description": "Rrp5, OB-fold domain 4", "go_ids": [], "go_terms": [], "name": "Rrp5_OB_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057302": {"description": "Rrp5, S1 domain", "go_ids": [], "go_terms": [], "name": "Rrp5_S1", "pathway_ids": ["R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901", "R-MMU-6791226"], "pathways": ["R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR057303": {"description": "Rod, N-terminal", "go_ids": [], "go_terms": [], "name": "Rod_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057304": {"description": "PDE8-like, REC N-terminal domain", "go_ids": [], "go_terms": [], "name": "PDE8-like_REC_N", "pathway_ids": ["R-HSA-418555", "R-MMU-418555", "R-DME-418555"], "pathways": ["R-HSA-418555:r:G alpha (s) signalling events", "R-MMU-418555:r:G alpha (s) signalling events", "R-DME-418555:r:G alpha (s) signalling events"], "type": "Domain"}, "IPR057305": {"description": "PDIA6-like, C-terminal thioredoxin-like domain", "go_ids": [], "go_terms": [], "name": "Thioredox_PDIA6_C", "pathway_ids": ["R-RNO-381426", "R-HSA-381038", "R-DME-381426", "R-DME-8957275", "R-RNO-8957275", "R-MMU-381426", "R-CEL-8957275", "R-CEL-381426", "R-HSA-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR057306": {"description": "PelB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "B-barrel_PelB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057307": {"description": "PEP5/VPS11 N-terminal", "go_ids": [], "go_terms": [], "name": "PEP5_VPS11_N", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR057308": {"description": "PEP5/VPS11, clathrin heavy-chain repeat", "go_ids": [], "go_terms": [], "name": "CHCR_PEP5_VPS11", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Repeat"}, "IPR057309": {"description": "Peptidoglycan hydrolase PcsB, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "PcsB_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057310": {"description": "Period circadian protein homolog PER 1-3, bHLH-like domain", "go_ids": [], "go_terms": [], "name": "PER1-3_bHLH", "pathway_ids": ["R-HSA-9931510", "R-RNO-9932298", "R-HSA-9931530", "R-MMU-9932298", "R-HSA-9932298", "R-HSA-9931521"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-RNO-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931530:r:Phosphorylation and nuclear translocation of the CRY:PER:kinase complex", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9932298:r:Degradation of CRY and PER proteins", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex"], "type": "Domain"}, "IPR057311": {"description": "GreAB-C-like domain", "go_ids": [], "go_terms": [], "name": "GrebAB-C-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057313": {"description": "Fatty acyl-CoA reductase Maqu_2507-like", "go_ids": [], "go_terms": [], "name": "Maqu_2507-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057314": {"description": "PUB2-4-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PUB2-4-like_N", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR057315": {"description": "PGAP2IP, C-terminal nuclease-like domain", "go_ids": [], "go_terms": [], "name": "Exo_endo_phos_PGAP2IP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057316": {"description": "Rab11-FIP3/4 domain", "go_ids": [], "go_terms": [], "name": "Rab11-FIP3/4_dom", "pathway_ids": ["R-MMU-5620916", "R-HSA-5620916", "R-DRE-5620916"], "pathways": ["R-MMU-5620916:r:VxPx cargo-targeting to cilium", "R-HSA-5620916:r:VxPx cargo-targeting to cilium", "R-DRE-5620916:r:VxPx cargo-targeting to cilium"], "type": "Domain"}, "IPR057317": {"description": "PH-like domain, trypanosoma", "go_ids": [], "go_terms": [], "name": "PH-like_tryp", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057318": {"description": "Renin receptor, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RENR_N", "pathway_ids": ["R-HSA-6798695", "R-BTA-2022377", "R-DME-6798695", "R-MMU-6798695", "R-DME-2022377", "R-BTA-6798695", "R-RNO-2022377", "R-HSA-2022377", "R-RNO-6798695", "R-MMU-2022377"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-BTA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-DME-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-BTA-6798695:r:Neutrophil degranulation", "R-RNO-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-HSA-2022377:r:Metabolism of Angiotensinogen to Angiotensins", "R-RNO-6798695:r:Neutrophil degranulation", "R-MMU-2022377:r:Metabolism of Angiotensinogen to Angiotensins"], "type": "Domain"}, "IPR057320": {"description": "RESC1/2, CYTH-like domain", "go_ids": [], "go_terms": [], "name": "RESC1_2_CYTH-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057321": {"description": "RFX1-4/6/8-like, BCD domain", "go_ids": [], "go_terms": [], "name": "RFX1-4/6/8-like_BCD", "pathway_ids": ["R-HSA-210745"], "pathways": ["R-HSA-210745:r:Regulation of gene expression in beta cells"], "type": "Domain"}, "IPR057322": {"description": "Rgr-1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Rgr-1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057323": {"description": "RHG40/28/18, C-terminal ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "RHG40/28/18_ubiquitin", "pathway_ids": ["R-HSA-8980692", "R-MMU-9013148", "R-HSA-9013148", "R-HSA-9013106", "R-MMU-9013106", "R-MMU-8980692"], "pathways": ["R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Domain"}, "IPR057324": {"description": "Ribonuclease II, winged helix domain", "go_ids": [], "go_terms": [], "name": "WH_RNase_II", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057325": {"description": "RNA helicase DeaD, dimerization domain", "go_ids": [], "go_terms": [], "name": "DeaD_dimer", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057326": {"description": "Ketoreductase domain", "go_ids": [], "go_terms": [], "name": "KR_dom", "pathway_ids": ["R-HSA-9029558", "R-DDI-75105", "R-DME-8866907", "R-RNO-2046106", "R-HSA-9918487", "R-HSA-193368", "R-MTU-9635470", "R-RNO-75105", "R-HSA-199220", "R-DME-8866904", "R-DME-2046106", "R-MMU-199220", "R-RNO-199220", "R-XTR-75896", "R-DRE-75105", "R-RNO-9033241", "R-MMU-389887", "R-RNO-389887", "R-BTA-9837999", "R-DDI-199220", "R-HSA-2187335", "R-DME-390247", "R-DME-1251985", "R-HSA-9918481", "R-DME-75896", "R-HSA-2426168", "R-HSA-163765", "R-BTA-70895", "R-MMU-2046106", "R-MMU-193368", "R-DME-9033241", "R-DME-9837999", "R-DME-389887", "R-HSA-389887", "R-HSA-5365859", "R-DME-70895", "R-MMU-9033241", "R-MMU-75105", "R-CFA-75105", "R-BTA-75105", "R-MMU-5365859", "R-DRE-75896", "R-DME-193368", "R-HSA-75105", "R-HSA-390247", "R-MMU-390247", "R-RNO-193368", "R-MMU-2187335", "R-HSA-9033500", "R-HSA-2046106", "R-HSA-9033241", "R-RNO-390247"], "pathways": ["R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "R-DDI-75105:r:Fatty acyl-CoA biosynthesis", "R-DME-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-RNO-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9918487:r:Dengue Virus Genome Translation and Replication", "R-HSA-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MTU-9635470:r:Dimycocersyl phthiocerol biosynthesis", "R-RNO-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-199220:r:Vitamin B5 (pantothenate) metabolism", "R-DME-8866904:r:Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "R-DME-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-199220:r:Vitamin B5 (pantothenate) metabolism", "R-RNO-199220:r:Vitamin B5 (pantothenate) metabolism", "R-XTR-75896:r:Plasmalogen biosynthesis", "R-DRE-75105:r:Fatty acyl-CoA biosynthesis", "R-RNO-9033241:r:Peroxisomal protein import", "R-MMU-389887:r:Beta-oxidation of pristanoyl-CoA", "R-RNO-389887:r:Beta-oxidation of pristanoyl-CoA", "R-BTA-9837999:r:Mitochondrial protein degradation", "R-DDI-199220:r:Vitamin B5 (pantothenate) metabolism", "R-HSA-2187335:r:The retinoid cycle in cones (daylight vision)", "R-DME-390247:r:Beta-oxidation of very long chain fatty acids", "R-DME-1251985:r:Nuclear signaling by ERBB4", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-DME-75896:r:Plasmalogen biosynthesis", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-HSA-163765:r:ChREBP activates metabolic gene expression", "R-BTA-70895:r:Branched-chain amino acid catabolism", "R-MMU-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-MMU-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-DME-9033241:r:Peroxisomal protein import", "R-DME-9837999:r:Mitochondrial protein degradation", "R-DME-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-389887:r:Beta-oxidation of pristanoyl-CoA", "R-HSA-5365859:r:RA biosynthesis pathway", "R-DME-70895:r:Branched-chain amino acid catabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-MMU-75105:r:Fatty acyl-CoA biosynthesis", "R-CFA-75105:r:Fatty acyl-CoA biosynthesis", "R-BTA-75105:r:Fatty acyl-CoA biosynthesis", "R-MMU-5365859:r:RA biosynthesis pathway", "R-DRE-75896:r:Plasmalogen biosynthesis", "R-DME-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-HSA-75105:r:Fatty acyl-CoA biosynthesis", "R-HSA-390247:r:Beta-oxidation of very long chain fatty acids", "R-MMU-390247:r:Beta-oxidation of very long chain fatty acids", "R-RNO-193368:r:Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "R-MMU-2187335:r:The retinoid cycle in cones (daylight vision)", "R-HSA-9033500:r:TYSND1 cleaves peroxisomal proteins", "R-HSA-2046106:r:alpha-linolenic acid (ALA) metabolism", "R-HSA-9033241:r:Peroxisomal protein import", "R-RNO-390247:r:Beta-oxidation of very long chain fatty acids"], "type": "Domain"}, "IPR057327": {"description": "RNA-binding protein vts1-like, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "Vts1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057328": {"description": "RNase T2-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RNaseT2L_C", "pathway_ids": ["R-SCE-6798695"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR057329": {"description": "Rol-3, five-bladed beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_Rol-3", "pathway_ids": ["R-CEL-8863795"], "pathways": ["R-CEL-8863795:r:Downregulation of ERBB2 signaling"], "type": "Domain"}, "IPR057330": {"description": "Rv3818-like, SCP2-like domain", "go_ids": [], "go_terms": [], "name": "SCP2_Rv3818", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057331": {"description": "Salactin", "go_ids": [], "go_terms": [], "name": "Salactin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057332": {"description": "SBNO, alpha/beta domain", "go_ids": [], "go_terms": [], "name": "SBNO_a/b_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057333": {"description": "Adhesion GPCR Gpr126, SEA domain", "go_ids": [], "go_terms": [], "name": "SEA_Gpr126", "pathway_ids": ["R-HSA-9619665", "R-DRE-9619665", "R-MMU-9619665"], "pathways": ["R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-DRE-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-MMU-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "type": "Domain"}, "IPR057334": {"description": "LRR-containing protein, second PH domain", "go_ids": [], "go_terms": [], "name": "PH_2nd_LRR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057335": {"description": "Selenocysteine-specific elongation factor, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "Beta-barrel_SelB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057336": {"description": "Spore germination protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GerAC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057337": {"description": "Sororin, C-terminal region", "go_ids": [], "go_terms": [], "name": "Sororin_C", "pathway_ids": ["R-HSA-2468052", "R-HSA-2500257", "R-HSA-2467813"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids"], "type": "Domain"}, "IPR057338": {"description": "Smf/DprA, SAM domain", "go_ids": [], "go_terms": [], "name": "DprA_SAM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057339": {"description": "Target of rapamycin complex 2 subunit MAPKAP1-like, Ras-binding domain", "go_ids": [], "go_terms": [], "name": "RBD_SIN1", "pathway_ids": ["R-MMU-9856530", "R-MMU-5218920", "R-HSA-5674400", "R-RNO-1257604", "R-MMU-6804757", "R-GGA-6804757", "R-MMU-1257604", "R-CEL-6804757", "R-GGA-389357", "R-RNO-5218920", "R-RNO-9856530", "R-MMU-389357", "R-RNO-6804757", "R-HSA-5218920", "R-CEL-1257604", "R-CEL-389357", "R-HSA-6804757", "R-GGA-9856530", "R-HSA-389357", "R-HSA-9920951", "R-HSA-9856530", "R-CEL-9856530", "R-HSA-1257604", "R-GGA-5218920", "R-GGA-1257604", "R-CEL-5218920", "R-RNO-389357"], "pathways": ["R-MMU-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-GGA-6804757:r:Regulation of TP53 Degradation", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-GGA-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-389357:r:CD28 dependent PI3K/Akt signaling", "R-RNO-6804757:r:Regulation of TP53 Degradation", "R-HSA-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-1257604:r:PIP3 activates AKT signaling", "R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-6804757:r:Regulation of TP53 Degradation", "R-GGA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-GGA-5218920:r:VEGFR2 mediated vascular permeability", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-RNO-389357:r:CD28 dependent PI3K/Akt signaling"], "type": "Domain"}, "IPR057340": {"description": "Single-strand DNA endonuclease 1, chromo domain", "go_ids": [], "go_terms": [], "name": "Chromo_SEND1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057344": {"description": "SRB8, ARM-like domain", "go_ids": [], "go_terms": [], "name": "ARM_SRB8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057345": {"description": "Transcription initiation factor TFIID subunit 2, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig-like_TAF2", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DRE-73779", "R-DME-76042", "R-MMU-6804756", "R-DME-73779", "R-DRE-75953", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-HSA-73776", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-CEL-73776", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-DRE-6804756", "R-DRE-76042", "R-DME-674695", "R-DRE-73776", "R-MMU-674695", "R-SCE-76042", "R-DME-6804756", "R-HSA-167161", "R-CEL-674695", "R-HSA-6804756", "R-DRE-674695", "R-SCE-674695", "R-SPO-73779", "R-HSA-76042", "R-HSA-674695", "R-SPO-73776", "R-CEL-76042", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR057346": {"description": "Talin-1/2, VBS2 domain", "go_ids": [], "go_terms": [], "name": "Talin1/2_VBS2", "pathway_ids": ["R-HSA-381038", "R-MMU-5674135", "R-HSA-5674135", "R-HSA-445355", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-9656223", "R-MMU-399955", "R-HSA-354194", "R-MMU-354194", "R-MMU-445355", "R-HSA-6802955", "R-MMU-372708", "R-HSA-114608", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-399955", "R-HSA-9856530", "R-HSA-372708", "R-HSA-354192", "R-MMU-354192", "R-MMU-114608"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-445355:r:Smooth Muscle Contraction", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9656223:r:Signaling by RAF1 mutants", "R-MMU-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-445355:r:Smooth Muscle Contraction", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-399955:r:SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-354192:r:Integrin signaling", "R-MMU-354192:r:Integrin signaling", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR057347": {"description": "TANGO6, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TANGO6_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057348": {"description": "TELO2, ARM repeat domain", "go_ids": [], "go_terms": [], "name": "TELO2_ARM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057349": {"description": "Meiotically up-regulated Mug190 protein, third C2 domain", "go_ids": [], "go_terms": [], "name": "C2_Mug190_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057350": {"description": "Thrombomodulin-like domain", "go_ids": [], "go_terms": [], "name": "THBD", "pathway_ids": ["R-HSA-140875", "R-HSA-202733", "R-MMU-202733", "R-MMU-140875"], "pathways": ["R-HSA-140875:r:Common Pathway of Fibrin Clot Formation", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-140875:r:Common Pathway of Fibrin Clot Formation"], "type": "Domain"}, "IPR057351": {"description": "Transmembrane protein 225 domain", "go_ids": [], "go_terms": [], "name": "TM225_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057352": {"description": "TmcB/TmcC, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_TmcB/C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057353": {"description": "TNF receptor-like domain", "go_ids": [], "go_terms": [], "name": "TNFR_nem", "pathway_ids": ["R-CEL-216083", "R-CEL-1474228", "R-CEL-2129379", "R-CEL-8957275", "R-CEL-381426", "R-CEL-1566948", "R-CEL-2173789"], "pathways": ["R-CEL-216083:r:Integrin cell surface interactions", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-1566948:r:Elastic fibre formation", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs"], "type": "Domain"}, "IPR057354": {"description": "Toc75-like, POTRA domain", "go_ids": [], "go_terms": [], "name": "POTRA1_3_Toc75", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057355": {"description": "Toc75-like, second POTRA domain", "go_ids": [], "go_terms": [], "name": "POTRA2_Toc75", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057356": {"description": "ZNF592-like, C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_ZNF592", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057357": {"description": "ZFAND2A/B-like, C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_ZFAND2A/B", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057358": {"description": "ZFAND1-like, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "UBL_ZFAND1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057359": {"description": "YfjL-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YfjL_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057360": {"description": "YxzE-like putative bacteriocin", "go_ids": [], "go_terms": [], "name": "YxzE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057361": {"description": "WD repeat-containing protein 35, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_WDR35", "pathway_ids": ["R-MMU-5620924", "R-RNO-5610787", "R-RNO-5620924", "R-HSA-5620924", "R-HSA-5610787", "R-MMU-5610787"], "pathways": ["R-MMU-5620924:r:Intraflagellar transport", "R-RNO-5610787:r:Hedgehog 'off' state", "R-RNO-5620924:r:Intraflagellar transport", "R-HSA-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state"], "type": "Repeat"}, "IPR057362": {"description": "WDGH domain", "go_ids": [], "go_terms": [], "name": "WDGH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057363": {"description": "Volactin", "go_ids": [], "go_terms": [], "name": "Volactin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057365": {"description": "Up-regulator of cell proliferation-like domain", "go_ids": [], "go_terms": [], "name": "URGCP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057366": {"description": "TRPM-like domain", "go_ids": [], "go_terms": [], "name": "TRPM-like", "pathway_ids": ["R-HSA-6798695", "R-DME-3295583", "R-HSA-9717207", "R-RNO-3295583", "R-CEL-3295583", "R-DRE-6798695", "R-MMU-3295583", "R-MMU-6798695", "R-DRE-3295583", "R-HSA-9824594", "R-RNO-6798695", "R-HSA-3295583"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DME-3295583:r:TRP channels", "R-HSA-9717207:r:Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-RNO-3295583:r:TRP channels", "R-CEL-3295583:r:TRP channels", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-3295583:r:TRP channels", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-3295583:r:TRP channels", "R-HSA-9824594:r:Regulation of MITF-M-dependent genes involved in apoptosis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-3295583:r:TRP channels"], "type": "Domain"}, "IPR057367": {"description": "Transmembrane protein PVRIG, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig_PVRIG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057368": {"description": "USP32, N-terminal domain", "go_ids": [], "go_terms": [], "name": "USP32_N", "pathway_ids": ["R-CEL-5689880"], "pathways": ["R-CEL-5689880:r:Ub-specific processing proteases"], "type": "Domain"}, "IPR057369": {"description": "VG15 protein", "go_ids": [], "go_terms": [], "name": "VG15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057370": {"description": "Endolysin-like domain", "go_ids": [], "go_terms": [], "name": "ELLD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057371": {"description": "Vitelline envelope sperm lysin receptor, C-terminal domain", "go_ids": [], "go_terms": [], "name": "VERL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057372": {"description": "UBP8/5-like, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "Ubiquitin_UBP8/5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057373": {"description": "ZNFX1 domain", "go_ids": [], "go_terms": [], "name": "ZNFX1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057375": {"description": "Probable ubiquitin-like-specific protease 2A/B, PH domain", "go_ids": [], "go_terms": [], "name": "ULP2A/B_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057376": {"description": "Trematode, PH-like domain", "go_ids": [], "go_terms": [], "name": "PH_trem", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057377": {"description": "Connectase MJ0548-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MJ0548_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057378": {"description": "Pre-tape measure protein", "go_ids": [], "go_terms": [], "name": "Pre_tape_measure", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057379": {"description": "Prospore membrane adapter protein SPO71, PH domain", "go_ids": [], "go_terms": [], "name": "PH_SPO71", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057380": {"description": "Protein kinase SIK1/2/3, UBA domain", "go_ids": [], "go_terms": [], "name": "UBA_SIK1/2/3", "pathway_ids": ["R-HSA-9931510"], "pathways": ["R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes"], "type": "Domain"}, "IPR057381": {"description": "Zinc finger, Tenuivirus", "go_ids": [], "go_terms": [], "name": "Znf_Tenuivirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057382": {"description": "Type VI secretion system effector TseH-like", "go_ids": [], "go_terms": [], "name": "TseH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057383": {"description": "Type I Thoeris inhibitor Tad3", "go_ids": [], "go_terms": [], "name": "Tad3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057384": {"description": "Myxosortase MrtX", "go_ids": [], "go_terms": [], "name": "CAAX_MXAN_2755", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057385": {"description": "Type I Thoeris inhibitor Tad4-like", "go_ids": [], "go_terms": [], "name": "Tad4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057386": {"description": "Type I Thoeris inhibitor Tad6-like", "go_ids": [], "go_terms": [], "name": "Tad6-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057388": {"description": "UGP3-like, C-terminal hexapeptide repeats", "go_ids": [], "go_terms": [], "name": "Hexapep_UGP3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057389": {"description": "Phage zinc binding", "go_ids": [], "go_terms": [], "name": "Zn-bd_phage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057390": {"description": "Phage zinc binding 6", "go_ids": [], "go_terms": [], "name": "Zn-bd_phage_6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057391": {"description": "Phage zinc binding 4", "go_ids": [], "go_terms": [], "name": "Zn-bd_phage_4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057392": {"description": "Phage zinc binding 5", "go_ids": [], "go_terms": [], "name": "Zn-bd_phage_5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057393": {"description": "PIC/HAP1/IgA0-like, second beta-solenoid repeat region", "go_ids": [], "go_terms": [], "name": "PIC_HAP1_IgA0_b-sol2", "pathway_ids": ["PWY-7884", "R-HSA-9760173", "R-HSA-9927020"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)", "R-HSA-9760173:r:Secretion of toxins", "R-HSA-9927020:r:Heme assimilation"], "type": "Domain"}, "IPR057394": {"description": "PIGBOS1-like", "go_ids": [], "go_terms": [], "name": "PIGBOS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057397": {"description": "5MP1/2-like, HEAT domain", "go_ids": [], "go_terms": [], "name": "HEAT_5MP1_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057398": {"description": "Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 2", "go_ids": [], "go_terms": [], "name": "GRESAG4.1/3_peripasmic_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057399": {"description": "Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 1", "go_ids": [], "go_terms": [], "name": "GRESAG4.1/3_peripasmic_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057400": {"description": "ADGRF3/5-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ADGRF3/5_N", "pathway_ids": ["R-HSA-5683826", "R-MMU-5683826", "R-RNO-5683826"], "pathways": ["R-HSA-5683826:r:Surfactant metabolism", "R-MMU-5683826:r:Surfactant metabolism", "R-RNO-5683826:r:Surfactant metabolism"], "type": "Domain"}, "IPR057401": {"description": "Adt-1/2-like domain", "go_ids": [], "go_terms": [], "name": "Adt-1/2-like_dom", "pathway_ids": ["R-CEL-5173214"], "pathways": ["R-CEL-5173214:r:O-glycosylation of TSR domain-containing proteins"], "type": "Domain"}, "IPR057402": {"description": "BBC1/AIM3, cysteine proteinase-fold domain", "go_ids": [], "go_terms": [], "name": "AIM3_BBC1_C", "pathway_ids": ["R-SPO-5668599"], "pathways": ["R-SPO-5668599:r:RHO GTPases Activate NADPH Oxidases"], "type": "Domain"}, "IPR057403": {"description": "Aladin, seven-bladed propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_Aladin", "pathway_ids": ["R-HSA-180910", "R-MMU-3232142", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-8980692", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-159230", "R-HSA-159227", "R-HSA-159230", "R-MMU-4085377", "R-MMU-4551638", "R-HSA-168333", "R-HSA-3371453", "R-HSA-165054", "R-HSA-4570464", "R-DME-4615885", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-HSA-168276", "R-DME-8980692", "R-HSA-168271", "R-HSA-6784531", "R-MMU-3301854", "R-DME-4551638", "R-HSA-4085377", "R-HSA-168325", "R-DME-159227", "R-MMU-170822", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-159230", "R-MMU-159227", "R-DME-3301854", "R-HSA-8980692", "R-HSA-5619107", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Domain"}, "IPR057404": {"description": "Protein root UVB sensitive 6, N-terminal", "go_ids": [], "go_terms": [], "name": "RUS6_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057405": {"description": "Proteasome-activating nucleotidase 2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PAN-2_N", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR057406": {"description": "Pua-like domain", "go_ids": [], "go_terms": [], "name": "Pua-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057407": {"description": "TANGO6, HEAT repeat", "go_ids": [], "go_terms": [], "name": "HEAT_TANGO6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057408": {"description": "Proteasome-activating nucleotidase 2, AAA+ lid C-terminal domain", "go_ids": [], "go_terms": [], "name": "PAN-2_AAA_lid", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR057409": {"description": "HVO_B0008-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HVO_B0008-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057410": {"description": "HVO_B0008-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HVO_B0008-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057411": {"description": "Intraflagellar transport protein 122 homolog, TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_IFT122", "pathway_ids": ["R-XTR-5610787", "R-MMU-5620924", "R-HSA-5610787", "R-HSA-5620924", "R-XTR-5620924", "R-MMU-5610787", "R-CEL-5620924", "R-CEL-5610787"], "pathways": ["R-XTR-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-5610787:r:Hedgehog 'off' state", "R-HSA-5620924:r:Intraflagellar transport", "R-XTR-5620924:r:Intraflagellar transport", "R-MMU-5610787:r:Hedgehog 'off' state", "R-CEL-5620924:r:Intraflagellar transport", "R-CEL-5610787:r:Hedgehog 'off' state"], "type": "Domain"}, "IPR057412": {"description": "Integrator complex subunit 4/Protein SIEL, C-terminal Ig-like domain", "go_ids": [], "go_terms": [], "name": "INTS4_C", "pathway_ids": ["R-HSA-6807505", "R-DME-6807505", "R-MMU-6807505", "R-DDI-6807505"], "pathways": ["R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR057413": {"description": "Integrator complex subunit 6-like, beta-barrel domain", "go_ids": [], "go_terms": [], "name": "Beta-barrel_INTS6", "pathway_ids": ["R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505", "R-DDI-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DDI-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR057414": {"description": "Interferon regulatory factor 2-binding protein 1/2-like, C3HC4 zinc finger domain", "go_ids": [], "go_terms": [], "name": "Zf-C3HC4_IRF-2BP1_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057415": {"description": "Cytochrome b6-f complex iron-sulfur subunit-like, transmembrane anchor", "go_ids": [], "go_terms": [], "name": "TM_PetC", "pathway_ids": ["PWY-101", "PWY-8270", "PWY-8271"], "pathways": ["PWY-101:t:photosynthesis light reactions", "PWY-8270:t:cyclic electron flow", "PWY-8271:t:NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)"], "type": "Domain"}, "IPR057416": {"description": "ISE2-like, SH3 domain", "go_ids": [], "go_terms": [], "name": "SH3_ISE2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057417": {"description": "PH-like domain 2, trypanosoma", "go_ids": [], "go_terms": [], "name": "PH-like_trypanosoma", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057418": {"description": "PH-like domain, kinetoplastida", "go_ids": [], "go_terms": [], "name": "PH-like_kinetoplastida", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057419": {"description": "PH-like domain 2, kinetoplastida", "go_ids": [], "go_terms": [], "name": "PH-like_2_kinetoplastida", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057420": {"description": "Lambda-carrageenase, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_CGLA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057421": {"description": "Lambda-carrageenase, middle domain", "go_ids": [], "go_terms": [], "name": "CGLA_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057422": {"description": "Lambda-carrageenase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CGLA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057424": {"description": "Doublecortin domain-containing protein 1-like, ubiquitin domain", "go_ids": [], "go_terms": [], "name": "Ubiquitin_DCDC1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057425": {"description": "DUF2921, lipocalin-like domain", "go_ids": [], "go_terms": [], "name": "DUF2921_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057426": {"description": "E3 ubiquitin-protein ligase RNF31, third UBA domain", "go_ids": [], "go_terms": [], "name": "RNF31_UBA_3", "pathway_ids": ["R-MMU-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-MMU-5357956", "R-HSA-5357786", "R-MMU-5357905"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling"], "type": "Domain"}, "IPR057427": {"description": "E3 ubiquitin-protein ligase WAV3-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "WAV3_C", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR057428": {"description": "EFHB, C-terminal EF-hand domain", "go_ids": [], "go_terms": [], "name": "EFHB_EF-hand_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057429": {"description": "eIF2D, winged helix domain", "go_ids": [], "go_terms": [], "name": "WH_eIF2D", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057430": {"description": "LDLRAD1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LDLRAD1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057431": {"description": "Light dependent period A-like, Fe-S cluster-binding domain", "go_ids": [], "go_terms": [], "name": "LdpA_Fe-S-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057432": {"description": "Lin-15A/B-like domain", "go_ids": [], "go_terms": [], "name": "Lin-15A/B-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057433": {"description": "Lipase maturation factor 1/2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LMF1/2_C", "pathway_ids": ["R-MMU-8963889", "R-XTR-8963889", "R-HSA-8963889", "R-RNO-8963889"], "pathways": ["R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-XTR-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-RNO-8963889:r:Assembly of active LPL and LIPC lipase complexes"], "type": "Domain"}, "IPR057434": {"description": "Lipase maturation factor 1/2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LMF1/2_N", "pathway_ids": ["R-MMU-8963889", "R-XTR-8963889", "R-HSA-8963889", "R-RNO-8963889"], "pathways": ["R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-XTR-8963889:r:Assembly of active LPL and LIPC lipase complexes", 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"Rtel1_ARCH", "pathway_ids": ["R-HSA-2564830", "R-HSA-5693554", "R-DRE-171319", "R-RNO-171319", "R-HSA-171319", "R-MMU-171319"], "pathways": ["R-HSA-2564830:r:Cytosolic iron-sulfur cluster assembly", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-DRE-171319:r:Telomere Extension By Telomerase", "R-RNO-171319:r:Telomere Extension By Telomerase", "R-HSA-171319:r:Telomere Extension By Telomerase", "R-MMU-171319:r:Telomere Extension By Telomerase"], "type": "Domain"}, "IPR057499": {"description": "FKB95-like, N-terminal Kelch domain", "go_ids": [], "go_terms": [], "name": "Kelch_FKB95", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057500": {"description": "DCK1-like, fourth C2 domain", "go_ids": [], "go_terms": [], "name": "C2_DCK1_4th", "pathway_ids": ["R-SCE-6798695", "R-SCE-9013149", "R-SCE-983231"], "pathways": ["R-SCE-6798695:r:Neutrophil degranulation", "R-SCE-9013149:r:RAC1 GTPase cycle", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR057501": {"description": "Ubiquitin-like-specific protease B, PH domain", "go_ids": [], "go_terms": [], "name": "ULPB_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057502": {"description": "PH-like domain, fungal", "go_ids": [], "go_terms": [], "name": "PH_25", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057503": {"description": "RdRP-like, PH domain", "go_ids": [], "go_terms": [], "name": "PH_RdRP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057505": {"description": "SH3b, T C-terminal domain", "go_ids": [], "go_terms": [], "name": "SH3b_T_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057506": {"description": "GPCPD1-like, C2 domain", "go_ids": [], "go_terms": [], "name": "C2_GPCPD1", "pathway_ids": ["R-SCE-204005", "R-SCE-983168", "R-SCE-3295583", "R-HSA-1483152", "R-HSA-1483115"], "pathways": ["R-SCE-204005:r:COPII-mediated vesicle transport", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-3295583:r:TRP channels", "R-HSA-1483152:r:Hydrolysis of LPE", "R-HSA-1483115:r:Hydrolysis of LPC"], "type": "Domain"}, "IPR057507": {"description": "Shavenoid isoform B-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Sha_B-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057508": {"description": "SHC SH2 domain-binding protein 1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SHCBP-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057509": {"description": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, second C2 domain", "go_ids": [], "go_terms": [], "name": "C2_SHIP1-2_2nd", "pathway_ids": ["PWY-6368", "R-CFA-1855204", "R-DRE-1855204", "R-CFA-1660499", "R-HSA-9680350", "R-MMU-210990", "R-HSA-1660499", "R-MMU-1660499", "R-RNO-912526", "R-HSA-210990", "R-MMU-912526", "R-CFA-912526", "R-RNO-1660499", "R-RNO-210990", "R-HSA-912526", "R-RNO-202424", "R-HSA-1855204", "R-RNO-1855204", "R-MMU-1855204", "R-HSA-202424", "R-DRE-1660499", "R-MMU-202424"], "pathways": ["PWY-6368:t:3-phosphoinositide degradation", "R-CFA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-210990:r:PECAM1 interactions", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-210990:r:PECAM1 interactions", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-CFA-912526:r:Interleukin receptor SHC signaling", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-202424:r:Downstream TCR signaling", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-202424:r:Downstream TCR signaling"], "type": "Domain"}, "IPR057510": {"description": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, first C2 domain", "go_ids": [], "go_terms": [], "name": "C2_SHIP1-2_first", "pathway_ids": ["PWY-6368", "R-CFA-1855204", "R-DRE-1855204", "R-CFA-1660499", "R-HSA-9680350", "R-MMU-210990", "R-HSA-1660499", "R-MMU-1660499", "R-RNO-912526", "R-HSA-210990", "R-MMU-912526", "R-CFA-912526", "R-RNO-1660499", "R-RNO-210990", "R-HSA-912526", "R-RNO-202424", "R-HSA-1855204", "R-RNO-1855204", "R-MMU-1855204", "R-HSA-202424", "R-DRE-1660499", "R-MMU-202424"], "pathways": ["PWY-6368:t:3-phosphoinositide degradation", "R-CFA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-DRE-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-CFA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-HSA-9680350:r:Signaling by CSF1 (M-CSF) in myeloid cells", "R-MMU-210990:r:PECAM1 interactions", "R-HSA-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-912526:r:Interleukin receptor SHC signaling", "R-HSA-210990:r:PECAM1 interactions", "R-MMU-912526:r:Interleukin receptor SHC signaling", "R-CFA-912526:r:Interleukin receptor SHC signaling", "R-RNO-1660499:r:Synthesis of PIPs at the plasma membrane", "R-RNO-210990:r:PECAM1 interactions", "R-HSA-912526:r:Interleukin receptor SHC signaling", "R-RNO-202424:r:Downstream TCR signaling", "R-HSA-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-RNO-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-MMU-1855204:r:Synthesis of IP3 and IP4 in the cytosol", "R-HSA-202424:r:Downstream TCR signaling", "R-DRE-1660499:r:Synthesis of PIPs at the plasma membrane", "R-MMU-202424:r:Downstream TCR signaling"], "type": "Domain"}, "IPR057511": {"description": "GDS1, winged helix domain", "go_ids": [], "go_terms": [], "name": "WH_GDS1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057512": {"description": "RTG2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RTG2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057513": {"description": "Rv1893-like", "go_ids": [], "go_terms": [], "name": "Rv1893", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057514": {"description": "SigF-like, NTF2-like domain", "go_ids": [], "go_terms": [], "name": "NTF2_SigF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057515": {"description": "Signal transducer and activator of transcription b, N-terminal", "go_ids": [], "go_terms": [], "name": "STATB_N", "pathway_ids": ["R-CEL-1059683", "R-CEL-201556", "R-CEL-9860927", "R-CEL-9020956", "R-CEL-6785807", "R-CEL-3249367", "R-CEL-9833482", "R-CEL-9701898", "R-CEL-8854691", "R-CEL-1251985", "R-CEL-9020591", "R-CEL-6783783", "R-CEL-909733", "R-CEL-877300", "R-CEL-1169408", "R-CEL-8984722", "R-CEL-9020933", "R-CEL-877312", "R-CEL-8983432", "R-CEL-8985947", "R-CEL-9008059", "R-CEL-186763"], "pathways": ["R-CEL-1059683:r:Interleukin-6 signaling", "R-CEL-201556:r:Signaling by ALK", "R-CEL-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-CEL-9020956:r:Interleukin-27 signaling", "R-CEL-6785807:r:Interleukin-4 and Interleukin-13 signaling", "R-CEL-3249367:r:STAT6-mediated induction of chemokines", "R-CEL-9833482:r:PKR-mediated signaling", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-CEL-8854691:r:Interleukin-20 family signaling", "R-CEL-1251985:r:Nuclear signaling by ERBB4", "R-CEL-9020591:r:Interleukin-12 signaling", "R-CEL-6783783:r:Interleukin-10 signaling", "R-CEL-909733:r:Interferon alpha/beta signaling", "R-CEL-877300:r:Interferon gamma signaling", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-CEL-8984722:r:Interleukin-35 Signalling", "R-CEL-9020933:r:Interleukin-23 signaling", "R-CEL-877312:r:Regulation of IFNG signaling", "R-CEL-8983432:r:Interleukin-15 signaling", "R-CEL-8985947:r:Interleukin-9 signaling", "R-CEL-9008059:r:Interleukin-37 signaling", "R-CEL-186763:r:Downstream signal transduction"], "type": "Domain"}, "IPR057517": {"description": "Single-strand DNA deaminase toxin A-like, C-terminal", "go_ids": [], "go_terms": [], "name": "SsdA-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057518": {"description": "GRPD, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GRDP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057520": {"description": "GRHL1/CP2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GRHL1/CP2_C", "pathway_ids": ["R-HSA-1989781"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression"], "type": "Domain"}, "IPR057522": {"description": "DNA utilization protein HofO, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HofO_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057523": {"description": "HTH three-helical bundle domain", "go_ids": [], "go_terms": [], "name": "HTH_74", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057524": {"description": "Csa3, HTH domain", "go_ids": [], "go_terms": [], "name": "HTH_Csa3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057525": {"description": "U3 small nucleolar RNA-associated protein 20, C-terminal", "go_ids": [], "go_terms": [], "name": "UTP20_C", "pathway_ids": ["R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR057527": {"description": "HVO_A0261-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HVO_A0261-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057528": {"description": "Protein-tyrosine-phosphatase MKP1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MPK1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057529": {"description": "MRCK/ROCK kinase, PH domain", "go_ids": [], "go_terms": [], "name": "MRCK/ROCK_PH", "pathway_ids": ["R-RNO-9013026", "R-HSA-6798695", "R-HSA-9013409", "R-RNO-6798695", "R-HSA-416572", "R-HSA-9013422", "R-RNO-9013422", "R-MMU-9013106", "R-MMU-8980692", "R-RNO-8980692", "R-RNO-416572", "R-RNO-9013149", "R-HSA-9013106", "R-MMU-4420097", "R-MMU-416572", "R-HSA-3928662", "R-CEL-9013149", "R-RNO-111465", "R-HSA-4420097", "R-MMU-9013422", "R-RNO-416482", "R-MMU-5627117", "R-HSA-9013148", "R-RNO-3928662", "R-DME-9013406", "R-CEL-9013406", "R-RNO-9013406", "R-RNO-9013106", "R-MMU-111465", "R-RNO-5627117", "R-DME-9013149", "R-MMU-9013407", "R-RNO-9013407", "R-HSA-416482", "R-HSA-9679191", "R-HSA-9696264", "R-HSA-9013149", "R-HSA-3928663", "R-HSA-8980692", "R-MMU-9013406", "R-MMU-9013026", "R-MMU-416482", "R-MMU-3928662", "R-HSA-111465", "R-HSA-9013026", "R-MMU-6798695", "R-RNO-9696264", "R-MMU-9696264", "R-HSA-9013406", "R-MMU-9013149", "R-RNO-4420097", "R-HSA-9013407", "R-HSA-5627117"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-RNO-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-CEL-9013149:r:RAC1 GTPase cycle", "R-RNO-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-MMU-5627117:r:RHO GTPases Activate ROCKs", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DME-9013406:r:RHOQ GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-RNO-9013106:r:RHOC GTPase cycle", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-RNO-5627117:r:RHO GTPases Activate ROCKs", "R-DME-9013149:r:RAC1 GTPase cycle", "R-MMU-9013407:r:RHOH GTPase cycle", "R-RNO-9013407:r:RHOH GTPase cycle", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-HSA-9679191:r:Potential therapeutics for SARS", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-3928663:r:EPHA-mediated growth cone collapse", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-9696264:r:RND3 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9013407:r:RHOH GTPase cycle", "R-HSA-5627117:r:RHO GTPases Activate ROCKs"], "type": "Domain"}, "IPR057530": {"description": "MTC6, partial TIM-barrel domain", "go_ids": [], "go_terms": [], "name": "TIM-barrel_MTC6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057531": {"description": "PUMA/OVT1, coiled-coil region", "go_ids": [], "go_terms": [], "name": "PUMA/OVT1_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057533": {"description": "Plexin-B, PSI domain", "go_ids": [], "go_terms": [], "name": "PSI_Plexin-B", "pathway_ids": ["R-HSA-9013405", "R-HSA-416550", "R-HSA-416572", "R-HSA-416700", "R-RNO-416700", "R-MMU-416482", "R-HSA-416482", "R-MMU-416700", "R-MMU-416572", "R-MMU-416550"], "pathways": ["R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-HSA-416700:r:Other semaphorin interactions", "R-RNO-416700:r:Other semaphorin interactions", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration"], "type": "Domain"}, "IPR057534": {"description": "Matrix-remodeling-associated protein 7, helical domain", "go_ids": [], "go_terms": [], "name": "MXRA7_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057535": {"description": "Myosin-1-3, N-terminal SH3 domain", "go_ids": [], "go_terms": [], "name": "MYO1-3_N_SH3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057536": {"description": "APX 1, N-terminal C2 domain", "go_ids": [], "go_terms": [], "name": "C2_N_APX", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057537": {"description": "C2CD3, N-terminal C2 domain", "go_ids": [], "go_terms": [], "name": "C2_C2CD3_N", "pathway_ids": ["R-XTR-5620912", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-XTR-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR057538": {"description": "RXYLT1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RXYLT1_C", "pathway_ids": ["PWY-7981", "R-HSA-9939291", "R-DRE-9939291", "R-MMU-9939291"], "pathways": ["PWY-7981:t:alpha-dystroglycan glycosylation", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-DRE-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1"], "type": "Domain"}, "IPR057539": {"description": "RXYLT1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RXYLT1_N", "pathway_ids": ["PWY-7981", "R-HSA-9939291", "R-DRE-9939291", "R-MMU-9939291"], "pathways": ["PWY-7981:t:alpha-dystroglycan glycosylation", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-DRE-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1"], "type": "Domain"}, "IPR057540": {"description": "Polycomb protein SUZ12-like, zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_SUZ12", "pathway_ids": ["R-MMU-8953750", "R-DME-9909649", "R-MMU-3214841", "R-HSA-2559580", "R-DRE-2559580", "R-DME-212300", "R-XTR-212300", "R-XTR-9764725", "R-DRE-8953750", "R-HSA-9764725", "R-MMU-212300", "R-HSA-8953750", "R-HSA-9609690", "R-MMU-9764725", "R-MMU-2559580", "R-MMU-8943724", "R-XTR-8953750", "R-HSA-9710421", "R-DME-2559580", "R-HSA-212300", "R-MMU-4551638", "R-HSA-9909649", "R-XTR-9909649", "R-DRE-3214841", "R-HSA-3214841", "R-MMU-9909649", "R-HSA-8943724", "R-DME-9764725", "R-XTR-2559580", "R-DME-8953750", "R-DME-8943724", "R-DRE-212300", "R-HSA-4551638", "R-DRE-9909649", "R-HSA-5617472", "R-DRE-9764725"], "pathways": ["R-MMU-8953750:r:Transcriptional Regulation by E2F6", "R-DME-9909649:r:Regulation of PD-L1(CD274) transcription", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-2559580:r:Oxidative Stress Induced Senescence", "R-DRE-2559580:r:Oxidative Stress Induced Senescence", "R-DME-212300:r:PRC2 methylates histones and DNA", "R-XTR-212300:r:PRC2 methylates histones and DNA", "R-XTR-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-DRE-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-212300:r:PRC2 methylates histones and DNA", "R-HSA-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-MMU-2559580:r:Oxidative Stress Induced Senescence", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-XTR-8953750:r:Transcriptional Regulation by E2F6", "R-HSA-9710421:r:Defective pyroptosis", "R-DME-2559580:r:Oxidative Stress Induced Senescence", "R-HSA-212300:r:PRC2 methylates histones and DNA", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-XTR-9909649:r:Regulation of PD-L1(CD274) transcription", "R-DRE-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-MMU-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-8943724:r:Regulation of PTEN gene transcription", "R-DME-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-XTR-2559580:r:Oxidative Stress Induced Senescence", "R-DME-8953750:r:Transcriptional Regulation by E2F6", "R-DME-8943724:r:Regulation of PTEN gene transcription", "R-DRE-212300:r:PRC2 methylates histones and DNA", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-DRE-9909649:r:Regulation of PD-L1(CD274) transcription", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-DRE-9764725:r:Negative Regulation of CDH1 Gene Transcription"], "type": "Domain"}, "IPR057541": {"description": "Phosphofurin acidic cluster sorting protein 1/2, N-terminal C2 domain", "go_ids": [], "go_terms": [], "name": "PACS1/2_N", "pathway_ids": ["R-HSA-164940"], "pathways": ["R-HSA-164940:r:Nef mediated downregulation of MHC class I complex cell surface expression"], "type": "Domain"}, "IPR057542": {"description": "U1 small nuclear ribonucleoprotein component SNU71, RNA binding domain", "go_ids": [], "go_terms": [], "name": "SNU71_RBD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057543": {"description": "U1 small nuclear ribonucleoprotein component SNU71, N-terminal", "go_ids": [], "go_terms": [], "name": "SNU71_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057544": {"description": "Transcription factor spt8, beta-propeller", "go_ids": [], "go_terms": [], "name": "Beta-prop_SPT8", "pathway_ids": ["R-SCE-983168"], "pathways": ["R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR057545": {"description": "Protein-arginine N-acetylglucosaminyltransferase SseK/NleB", "go_ids": ["GO:0106362"], "go_terms": ["GO:0106362:protein-arginine N-acetylglucosaminyltransferase activity:F"], "name": "SseK_NleB", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Family"}, "IPR057546": {"description": "Stalled ribosome sensor 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"R-XTR-2565942", "R-DDI-389357", "R-HSA-5663220", "R-RNO-9648025", "R-HSA-428890", "R-HSA-380259", "R-XTR-8854518", "R-XTR-2500257", "R-HSA-9633012", "R-MMU-2467813"], "pathways": ["R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-XTR-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-5620912:r:Anchoring of the basal 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"R-DDI-1632852:r:Macroautophagy", "R-RNO-68877:r:Mitotic Prometaphase", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DDI-166208:r:mTORC1-mediated signalling", "R-XTR-5663220:r:RHO GTPases Activate Formins", "R-XTR-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-XTR-68877:r:Mitotic Prometaphase", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-XTR-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-RNO-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-428890:r:Role of ABL in ROBO-SLIT signaling", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-XTR-8854518:r:AURKA Activation by TPX2", "R-XTR-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency", "R-MMU-2467813:r:Separation of Sister Chromatids"], "type": "Domain"}, "IPR057547": {"description": "Terminal repeat-encoded protein TreK-like, staphylococcus phage", "go_ids": [], "go_terms": [], "name": "Phage_TreK-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057548": {"description": "S-Adenosylmethionine lyase-like", "go_ids": [], "go_terms": [], "name": "S-AdoMet_lyase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057549": {"description": "Straight fiber protein PB4, spike domain", "go_ids": [], "go_terms": [], "name": "PB4_spike", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057550": {"description": "Straight fiber protein PB4, first Fn3-like domain", "go_ids": [], "go_terms": [], "name": "Fn3-I_PB4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057551": {"description": "Straight fiber 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"R-CEL-389357:r:CD28 dependent PI3K/Akt signaling", "R-DME-166208:r:mTORC1-mediated signalling", "R-SCE-1257604:r:PIP3 activates AKT signaling", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-9920951:r:Dengue virus modulates apoptosis", "R-DDI-5693607:r:Processing of DNA double-strand break ends", "R-SPO-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-SPO-6804757:r:Regulation of TP53 Degradation", "R-SPO-1257604:r:PIP3 activates AKT signaling", "R-SCE-3371571:r:HSF1-dependent transactivation", "R-HSA-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-SPO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-DME-9639288:r:Amino acids regulate mTORC1", "R-DDI-1632852:r:Macroautophagy", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-MMU-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-6804757:r:Regulation of TP53 Degradation", "R-DDI-166208:r:mTORC1-mediated signalling", "R-MMU-3371571:r:HSF1-dependent transactivation", "R-CEL-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-SPO-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-CEL-6804757:r:Regulation of TP53 Degradation", "R-MMU-8943724:r:Regulation of PTEN gene transcription", "R-MMU-6783310:r:Fanconi Anemia Pathway", "R-RNO-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-SPO-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-DDI-9664873:r:Pexophagy", "R-HSA-165159:r:MTOR signalling", "R-HSA-3371571:r:HSF1-dependent transactivation", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-166208:r:mTORC1-mediated signalling", "R-SPO-5693548:r:Sensing of DNA Double Strand Breaks", "R-HSA-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-166208:r:mTORC1-mediated signalling", "R-DME-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-SCE-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "type": "Domain"}, "IPR057565": {"description": "Transcription elongation regulator 1-like, third WW domain", "go_ids": [], "go_terms": [], "name": "WW_TCRG1_3rd", "pathway_ids": ["R-HSA-9770562", "R-HSA-72163", "R-MMU-9770562", "R-MMU-72163"], "pathways": ["R-HSA-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR057566": {"description": "TTI1, N-terminal TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_TTI1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057567": {"description": "TTI1, C-terminal TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_TTI1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057568": {"description": "CortBP2/NAV1-like, AAA+ ATPase lid domain", "go_ids": [], "go_terms": [], "name": "CortBP2_NAV1-like_AAA_lid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057569": {"description": "C2 domain, nematode", "go_ids": [], "go_terms": [], "name": "C2_nem", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057570": {"description": "NOL9, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NOL9_C", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-CEL-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DRE-6791226"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-CEL-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR057571": {"description": "SDR PhqE-like", "go_ids": [], "go_terms": [], "name": "SDR_PhqE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057572": {"description": "Non-GDSL lipase-like", "go_ids": [], "go_terms": [], "name": "NonGDSL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057573": {"description": "NOL9, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NOL9_N", "pathway_ids": ["R-DME-6791226", "R-MMU-6791226", "R-HSA-6791226", "R-DDI-6791226", "R-DRE-6791226"], "pathways": ["R-DME-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DDI-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR057574": {"description": "Novel STAND NTPase 5 domain", "go_ids": [], "go_terms": [], "name": "nSTAND_NTPase5_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057575": {"description": "Novel STAND NTPase 6 domain", "go_ids": [], "go_terms": [], "name": "nSTAND6_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057576": {"description": "NUCB1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NUCB1_N", "pathway_ids": ["R-RNO-381426", "R-MMU-381426", "R-HSA-8957275", "R-DME-381426", "R-DME-8957275", "R-RNO-8957275", "R-MMU-8957275", "R-HSA-381426"], "pathways": ["R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-DME-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-DME-8957275:r:Post-translational protein phosphorylation", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR057577": {"description": "Nucleoprotein, TPR/MPL1 domain", "go_ids": [], "go_terms": [], "name": "Nucleoprot-TPR/MLP1_dom", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-RNO-3301854", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-159230", "R-HSA-159227", "R-HSA-159230", "R-MMU-4085377", "R-RNO-159230", "R-MMU-4551638", "R-HSA-168333", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-DME-4615885", "R-HSA-4570464", "R-RNO-159236", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-DME-4551638", "R-MMU-3301854", "R-DME-159227", "R-HSA-4085377", "R-HSA-168325", "R-MMU-170822", "R-RNO-159227", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-DME-159230", "R-RNO-4551638", "R-HSA-3232142", "R-MMU-159227", "R-DME-3301854", "R-RNO-4085377", "R-HSA-3301854", "R-RNO-170822", "R-RNO-159231", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-HSA-9725370"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 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"name": "Phage_ssDNA_bind", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057582": {"description": "Putative phage tail tube protein", "go_ids": [], "go_terms": [], "name": "Phage_TTP_15", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057583": {"description": "PYCO1-like, Rubisco-binding repeat domain", "go_ids": [], "go_terms": [], "name": "PYCO1-like_Rubisco-bd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057584": {"description": "RDM3, beta-solenoid", "go_ids": [], "go_terms": [], "name": "RDM3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057585": {"description": "Tetratricopeptide repeat domain, fungi", "go_ids": [], "go_terms": [], "name": "TPR_dom_fungi", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057586": {"description": "NUP210, Ig-like domain 16", "go_ids": [], "go_terms": [], "name": "Ig_NUP210_16th", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-RNO-3301854", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230", "R-MMU-4085377", "R-MMU-4551638", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-DME-4615885", "R-HSA-4570464", "R-RNO-159236", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-DME-4551638", "R-MMU-3301854", "R-DME-159227", "R-HSA-4085377", "R-HSA-168325", "R-MMU-170822", "R-RNO-159227", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-DME-159230", "R-RNO-4551638", "R-HSA-3232142", "R-HSA-3301854", "R-DME-3301854", "R-RNO-4085377", "R-MMU-159227", "R-RNO-170822", "R-RNO-4570464", "R-RNO-159231", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746"], 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"R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR057657": {"description": "MAT1, C-terminal CAK anchor", "go_ids": [], "go_terms": [], "name": "MAT1_CAK-anch", "pathway_ids": ["R-HSA-73772", "R-MMU-73762", "R-HSA-6781827", "R-MMU-75953", "R-MMU-6782135", "R-MMU-113418", "R-HSA-427413", "R-HSA-69273", "R-HSA-72086", "R-HSA-69231", "R-HSA-6796648", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-HSA-6781823", "R-MMU-8939236", "R-HSA-167162", "R-MMU-69202", "R-HSA-167246", "R-MMU-5696395", "R-MMU-6781823", "R-HSA-73776", "R-HSA-69656", "R-HSA-167152", "R-HSA-75953", "R-HSA-113418", "R-HSA-6782210", "R-HSA-77075", "R-MMU-73776", "R-MMU-73779", "R-HSA-167172", "R-MMU-76042", "R-MMU-6796648", "R-MMU-73863", "R-HSA-6782135", "R-HSA-73762", "R-MMU-674695", "R-HSA-167161", "R-MMU-69656", "R-HSA-73863", "R-HSA-167200", "R-MMU-77075", "R-HSA-75955", "R-HSA-5696395", "R-HSA-167160", "R-MMU-73772", "R-MMU-6782210", "R-HSA-674695", "R-HSA-76042", "R-MMU-72086", "R-MMU-69273", "R-HSA-69202", "R-HSA-8939236", "R-HSA-112382", "R-HSA-73779", "R-MMU-69231"], "pathways": ["R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-6782135:r:Dual incision in TC-NER", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-72086:r:mRNA Capping", "R-HSA-69231:r:Cyclin D associated events in G1", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-MMU-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-MMU-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167161:r:HIV Transcription Initiation", "R-MMU-69656:r:Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-MMU-73772:r:RNA Polymerase I Promoter Escape", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-72086:r:mRNA Capping", "R-MMU-69273:r:Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-69202:r:Cyclin E associated events during G1/S transition", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-MMU-69231:r:Cyclin D associated events in G1"], "type": "Domain"}, "IPR057658": {"description": "CEP250, coiled coil", "go_ids": [], "go_terms": [], "name": "CEP250_CC", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR057659": {"description": "CEP152, CEP63 binding coiled coil", "go_ids": [], "go_terms": [], "name": "CEP152_CC", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR057661": {"description": "RsdA/BaiN/AoA(So)-like, Rossmann fold-like domain", "go_ids": [], "go_terms": [], "name": "RsdA/BaiN/AoA(So)_Rossmann", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057662": {"description": "CEP192, Aurora A binding region", "go_ids": [], "go_terms": [], "name": "CEP192_Aurora-A_bind", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Binding_site"}, "IPR057663": {"description": "TACC3, Aurora-A binding region", "go_ids": [], "go_terms": [], "name": "TACC3_Aurora-A_bind", "pathway_ids": ["R-HSA-9604323", "R-HSA-9013507"], "pathways": ["R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-HSA-9013507:r:NOTCH3 Activation and Transmission of Signal to the Nucleus"], "type": "Binding_site"}, "IPR057664": {"description": "CEP152, PLK4 binding region", "go_ids": [], "go_terms": [], "name": "CEP152_PLK4_bind", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Binding_site"}, "IPR057665": {"description": "CEP192, PLK4 binding region", "go_ids": [], "go_terms": [], "name": "CEP192_PLK4_bind", "pathway_ids": ["R-HSA-380320", "R-HSA-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Binding_site"}, "IPR057666": {"description": "Smf/DprA, SLOG domain", "go_ids": [], "go_terms": [], "name": "DrpA_SLOG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057667": {"description": "Sleeping Beauty transposase, HTH domain", "go_ids": [], "go_terms": [], "name": "HTH_SB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057668": {"description": "Non-canonical E2 ubiquitin-conjugating enzyme, C-terminal", "go_ids": [], "go_terms": [], "name": "E2_Ub-conjug_enz_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057669": {"description": "P3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "P3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057670": {"description": "Retroviral polymerase, SH3-like domain", "go_ids": [], "go_terms": [], "name": "SH3_retrovirus", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057671": {"description": "BRINP, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BRINP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057672": {"description": "IPO4/5-like, TPR repeats domain", "go_ids": [], "go_terms": [], "name": "TPR_IPO4/5", "pathway_ids": ["R-HSA-9615933", "R-HSA-5620924", "R-MMU-450513", "R-HSA-450513", "R-BTA-450513", "R-MMU-5620924", "R-HSA-192905"], "pathways": ["R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-5620924:r:Intraflagellar transport", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-192905:r:vRNP Assembly"], "type": "Domain"}, "IPR057674": {"description": "RBM22, CCCH zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf-CCCH_RBM22", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-RNO-72163", "R-HSA-9918481", "R-MMU-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR057676": {"description": "STK11-interacting protein, C-terminal PH domain", "go_ids": [], "go_terms": [], "name": "PH_S11IP_C", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR057677": {"description": "EndoE-GH18L, 2nd helical domain", "go_ids": [], "go_terms": [], "name": "EndoE-GH18L_3HB-2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057678": {"description": "Domain of unknown function DUF7918", "go_ids": [], "go_terms": [], "name": "DUF7918", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057679": {"description": "Domain of unknown function DUF7919", "go_ids": [], "go_terms": [], "name": "DUF7919", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057680": {"description": "Domain of unknown function DUF7920", "go_ids": [], "go_terms": [], "name": "DUF7920", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057681": {"description": "Domain of unknown function DUF7921", "go_ids": [], "go_terms": [], "name": "DUF7921", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057682": {"description": "Domain of unknown function DUF7922", "go_ids": [], "go_terms": [], "name": "DUF7922", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057683": {"description": "Domain of unknown function DUF7923", "go_ids": [], "go_terms": [], "name": "DUF7923", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057684": {"description": "Domain of unknown function DUF7924", "go_ids": [], "go_terms": [], "name": "DUF7924", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057685": {"description": "Domain of unknown function DUF7925", "go_ids": [], "go_terms": [], "name": "DUF7925", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057686": {"description": "Domain of unknown function DUF7926", "go_ids": [], "go_terms": [], "name": "DUF7926", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057687": {"description": "Domain of unknown function DUF7927", "go_ids": [], "go_terms": [], "name": "DUF7927", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057688": {"description": "Domain of unknown function DUF7928", "go_ids": [], "go_terms": [], "name": "DUF7928", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057689": {"description": "Domain of unknown function DUF7929", "go_ids": [], "go_terms": [], "name": "DUF7929", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057690": {"description": "Domain of unknown function DUF7930", "go_ids": [], "go_terms": [], "name": "DUF7930", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057691": {"description": "Domain of unknown function DUF7931", "go_ids": [], "go_terms": [], "name": "DUF7931", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057692": {"description": "Domain of unknown function DUF7932", "go_ids": [], "go_terms": [], "name": "DUF7932", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057693": {"description": "Domain of unknown function DUF7933", "go_ids": [], "go_terms": [], "name": "DUF7933", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057695": {"description": "Protein of unknown function DUF7935", "go_ids": [], "go_terms": [], "name": "DUF7935", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057696": {"description": "Protein of unknown function DUF7936", "go_ids": [], "go_terms": [], "name": "DUF7936", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057697": {"description": "Domain of unknown function DUF7937", "go_ids": [], "go_terms": [], "name": "DUF7937", "pathway_ids": [], 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{"description": "KCTD7/14, C-terminal domain", "go_ids": [], "go_terms": [], "name": "KCTD7/14_C", "pathway_ids": ["R-BTA-983168", "R-MMU-8951664", "R-BTA-8951664", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168", "R-DRE-8951664", "R-HSA-983168", "R-RNO-983168", "R-DRE-983168"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR057892": {"description": "Liprin-alpha, CC2 domain", "go_ids": [], "go_terms": [], "name": "LIP-1_CC2", "pathway_ids": ["R-HSA-181430", 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"R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-1227986:r:Signaling by ERBB2", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-HSA-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-1236394:r:Signaling by ERBB4", "R-RNO-1358803:r:Downregulation of ERBB2:ERBB3 signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-1236394:r:Signaling by ERBB4", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling"], "type": "Domain"}, "IPR057910": {"description": "Nanos, NED domain", "go_ids": [], "go_terms": [], "name": "NED_Nanos", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057912": {"description": "Mitochondrial protein cyt-4, OB-fold 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protein gp86", "go_ids": [], "go_terms": [], "name": "PhiKZ_Gp86", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057919": {"description": "Bacteriophage PhiKZ vertex-binding protein gp91", "go_ids": [], "go_terms": [], "name": "PhiKZ_Gp91", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057920": {"description": "Bacteriophage PhiKZ major capsid protein gp120", "go_ids": [], "go_terms": [], "name": "PhiKZ_MCP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057921": {"description": "Bacteriophage PhiKZ vertex-binding protein gp28", "go_ids": [], "go_terms": [], "name": "PhiKZ_VTX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057922": {"description": "Minor capsid protein P12/P13, Phycodnaviridae", "go_ids": [], "go_terms": [], "name": "P12/P13", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057923": {"description": "Putative capsid protein ORF9, Plectrovirus", "go_ids": [], "go_terms": [], "name": "Plectro_ORF9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057924": {"description": "Minor capsid protein VP2, Polyomaviruses", "go_ids": [], "go_terms": [], "name": "Polyoma_VP2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057925": {"description": "Double-stranded DNA deaminase toxin A, prePAAR motif", "go_ids": [], "go_terms": [], "name": "prePAAR_DddA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057926": {"description": "QRICH1-like domain", "go_ids": [], "go_terms": [], "name": "QRICH1_dom", "pathway_ids": ["R-HSA-9703465", "R-HSA-9764725", "R-HSA-5655302", "R-MMU-9764725", "R-HSA-1839117"], "pathways": ["R-HSA-9703465:r:Signaling by FLT3 fusion proteins", "R-HSA-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-MMU-9764725:r:Negative Regulation of CDH1 Gene Transcription", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR057927": {"description": "Checkpoint protein RAD24-like, helical bundle", "go_ids": [], "go_terms": [], "name": "RAD24-like_helical", "pathway_ids": ["R-SCE-176187", "R-SPO-176187"], "pathways": ["R-SCE-176187:r:Activation of ATR in response to replication stress", "R-SPO-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR057929": {"description": "RamC, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RamC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057930": {"description": "Antitoxin, putative", "go_ids": [], "go_terms": [], "name": "Antitoxin_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057931": {"description": "ERCC6L2-like, ribbon-helix-helix domain", "go_ids": [], "go_terms": [], "name": "RHH_ERCC6L2", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR057932": {"description": "Nesprin-1/3, spectrin repeats region", "go_ids": [], "go_terms": [], "name": "Spectrin_SYNE1_3", "pathway_ids": ["R-HSA-1221632"], "pathways": ["R-HSA-1221632:r:Meiotic synapsis"], "type": "Domain"}, "IPR057933": {"description": "Nesprin-3 domain", "go_ids": [], "go_terms": [], "name": "SYNE3_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057934": {"description": "Spt5, KOW domain repeat 7", "go_ids": [], "go_terms": [], "name": "KOW_Spt5_7", "pathway_ids": ["R-HSA-6807505", "R-GGA-112382", "R-HSA-167238", "R-GGA-75955", "R-MMU-113418", "R-GGA-674695", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DME-77075", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-DRE-6807505", "R-DRE-77075", "R-HSA-167287", "R-DRE-75955", "R-HSA-167246", "R-DRE-6796648", "R-DME-72086", "R-DRE-113418", "R-HSA-167152", "R-HSA-113418", "R-HSA-77075", "R-GGA-6796648", "R-DME-113418", "R-CEL-75955", "R-MMU-6796648", "R-GGA-6807505", "R-DME-674695", "R-HSA-167243", "R-DRE-72086", "R-HSA-167242", "R-CEL-113418", "R-CEL-77075", "R-MMU-674695", "R-MMU-6807505", "R-CEL-674695", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-DRE-674695", "R-MMU-77075", "R-HSA-75955", "R-CEL-112382", "R-HSA-167160", "R-MMU-72086", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-GGA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-GGA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-72086:r:mRNA Capping", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-GGA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-DRE-72086:r:mRNA Capping", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-MMU-72086:r:mRNA Capping", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR057935": {"description": "Spt5, KOW domain repeat 6, plant", "go_ids": [], "go_terms": [], "name": "KOW_Spt5_6_plant", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057936": {"description": "Spt5, KOWx domain", "go_ids": [], "go_terms": [], "name": "KOWx_Spt5", "pathway_ids": ["R-SPO-674695", "R-HSA-6807505", "R-GGA-112382", "R-HSA-167238", "R-GGA-75955", "R-MMU-113418", "R-GGA-674695", "R-DME-6796648", "R-CEL-72086", "R-HSA-72086", "R-DME-77075", "R-HSA-6796648", "R-DME-75955", "R-HSA-167158", "R-MMU-75955", "R-MMU-112382", "R-DRE-6807505", "R-DRE-77075", "R-HSA-167287", "R-DRE-75955", "R-HSA-167246", "R-DRE-6796648", "R-DME-72086", "R-DRE-113418", "R-HSA-167152", "R-HSA-113418", "R-HSA-77075", "R-SPO-6796648", "R-SPO-72086", "R-GGA-6796648", "R-SCE-6796648", "R-SPO-113418", "R-DME-113418", "R-SPO-77075", "R-CEL-75955", "R-MMU-6796648", "R-GGA-6807505", "R-DME-674695", "R-HSA-167243", "R-SCE-113418", "R-SCE-72086", "R-DRE-72086", "R-HSA-167242", "R-CEL-113418", "R-CEL-77075", "R-MMU-674695", "R-MMU-6807505", "R-CEL-674695", "R-DME-112382", "R-HSA-167290", "R-HSA-167200", "R-DRE-674695", "R-MMU-77075", "R-HSA-75955", "R-SCE-77075", "R-CEL-112382", "R-HSA-167160", "R-SCE-674695", "R-MMU-72086", "R-HSA-674695", "R-CEL-6796648", "R-HSA-112382"], "pathways": ["R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-GGA-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167238:r:Pausing and recovery of Tat-mediated HIV elongation", "R-GGA-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-113418:r:Formation of the Early Elongation Complex", "R-GGA-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-CEL-72086:r:mRNA Capping", "R-HSA-72086:r:mRNA Capping", "R-DME-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167158:r:Formation of the HIV-1 Early Elongation Complex", "R-MMU-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-112382:r:Formation of RNA Pol II elongation complex", "R-DRE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DRE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-167287:r:HIV elongation arrest and recovery", "R-DRE-75955:r:RNA Polymerase II Transcription Elongation", "R-HSA-167246:r:Tat-mediated elongation of the HIV-1 transcript", "R-DRE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-DME-72086:r:mRNA Capping", "R-DRE-113418:r:Formation of the Early Elongation Complex", "R-HSA-167152:r:Formation of HIV elongation complex in the absence of HIV Tat", "R-HSA-113418:r:Formation of the Early Elongation Complex", "R-HSA-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-SPO-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-72086:r:mRNA Capping", "R-GGA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-SPO-113418:r:Formation of the Early Elongation Complex", "R-DME-113418:r:Formation of the Early Elongation Complex", "R-SPO-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-75955:r:RNA Polymerase II Transcription Elongation", "R-MMU-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-GGA-6807505:r:RNA polymerase II transcribes snRNA genes", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-167243:r:Tat-mediated HIV elongation arrest and recovery", "R-SCE-113418:r:Formation of the Early Elongation Complex", "R-SCE-72086:r:mRNA Capping", "R-DRE-72086:r:mRNA Capping", "R-HSA-167242:r:Abortive elongation of HIV-1 transcript in the absence of Tat", "R-CEL-113418:r:Formation of the Early Elongation Complex", "R-CEL-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-DME-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167290:r:Pausing and recovery of HIV elongation", "R-HSA-167200:r:Formation of HIV-1 elongation complex containing HIV-1 Tat", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-HSA-75955:r:RNA Polymerase II Transcription Elongation", "R-SCE-77075:r:RNA Pol II CTD phosphorylation and interaction with CE", "R-CEL-112382:r:Formation of RNA Pol II elongation complex", "R-HSA-167160:r:RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-72086:r:mRNA Capping", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-CEL-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-112382:r:Formation of RNA Pol II elongation complex"], "type": "Domain"}, "IPR057937": {"description": "Transcription regulator HVO_2718-like, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "HVO_2718-like_HTH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057938": {"description": "TreTu toxin, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TreTu_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057939": {"description": "TRF2/HOY1, PH-like domain", "go_ids": [], "go_terms": [], "name": "TRF2_HOY1_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057940": {"description": "Tri-helical domain", "go_ids": [], "go_terms": [], "name": "Tri-helical_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057941": {"description": "Transportin-3/Importin-13, second TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_TNPO3_IPO13_2nd", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR057942": {"description": "Transportin-3/Importin-13, third TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_TNPO3_IPO13_3rd", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR057944": {"description": "TSTD2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TSTD2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057945": {"description": "ZSWIM8, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_ZSWIM8", "pathway_ids": ["R-HSA-9010553"], "pathways": ["R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs"], "type": "Domain"}, "IPR057946": {"description": "ZFYVE26-like, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_ZFYVE26", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057947": {"description": "Exportin-7/Ran-binding protein 17, TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_XPO7/RBP17", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057948": {"description": "E3 ubiquitin-protein ligase TRIP12-like, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_TRIP12_N", "pathway_ids": ["PWY-7511", "R-BTA-983168", "R-DRE-983168", "R-SPO-983168", "R-SCE-983168", "R-HSA-983168", "R-RNO-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR057949": {"description": "TEX10-like, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_TEX10", "pathway_ids": ["R-MMU-6791226", "R-HSA-6791226", "R-DRE-6791226"], "pathways": ["R-MMU-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-DRE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol"], "type": "Domain"}, "IPR057950": {"description": "RIMB1/RIM3A-C-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RIMB1/RIM3A-C-like_N", "pathway_ids": ["R-MMU-196108", "R-HSA-181429", "R-HSA-181430", "R-HSA-196108", "R-RNO-212676", "R-MMU-212676", "R-RNO-264642", "R-RNO-181430", "R-RNO-210500", "R-MMU-181430", "R-MMU-210500", "R-HSA-264642", "R-MMU-181429", "R-RNO-181429", "R-HSA-212676", "R-HSA-210500", "R-RNO-196108", "R-MMU-264642"], "pathways": ["R-MMU-196108:r:Pregnenolone biosynthesis", "R-HSA-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-HSA-196108:r:Pregnenolone biosynthesis", "R-RNO-212676:r:Dopamine Neurotransmitter Release Cycle", "R-MMU-212676:r:Dopamine Neurotransmitter Release Cycle", "R-RNO-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-RNO-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-RNO-210500:r:Glutamate Neurotransmitter Release Cycle", "R-MMU-181430:r:Norepinephrine Neurotransmitter Release Cycle", "R-MMU-210500:r:Glutamate Neurotransmitter Release Cycle", "R-HSA-264642:r:Acetylcholine Neurotransmitter Release Cycle", "R-MMU-181429:r:Serotonin Neurotransmitter Release Cycle", "R-RNO-181429:r:Serotonin Neurotransmitter Release Cycle", "R-HSA-212676:r:Dopamine Neurotransmitter Release Cycle", "R-HSA-210500:r:Glutamate Neurotransmitter Release Cycle", "R-RNO-196108:r:Pregnenolone biosynthesis", "R-MMU-264642:r:Acetylcholine Neurotransmitter Release Cycle"], "type": "Domain"}, "IPR057951": {"description": "CPSF6/7, RSLD domain, N-terminal region", "go_ids": [], "go_terms": [], "name": "CPSF6/7_RSLD_N", "pathway_ids": ["R-HSA-9013422", "R-HSA-9770562", "R-RNO-9013422", "R-DRE-77595", "R-MMU-9770562", "R-DME-77595", "R-MMU-77595", "R-HSA-73856", "R-RNO-77595", "R-MMU-73856", "R-HSA-72187", "R-DME-9013422", "R-RNO-73856", "R-HSA-77595", "R-DME-9770562", "R-MMU-9013422", "R-DRE-73856", "R-MMU-72187", "R-DRE-9770562", "R-RNO-9770562", "R-DME-73856", "R-DRE-9013422", "R-HSA-5655302", "R-HSA-9918481", "R-HSA-1839117"], "pathways": ["R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-9770562:r:mRNA Polyadenylation", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-RNO-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-72187:r:mRNA 3'-end processing", "R-DME-9013422:r:RHOBTB1 GTPase cycle", "R-RNO-73856:r:RNA Polymerase II Transcription Termination", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-MMU-72187:r:mRNA 3'-end processing", "R-DRE-9770562:r:mRNA Polyadenylation", "R-RNO-9770562:r:mRNA Polyadenylation", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-DRE-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-5655302:r:Signaling by FGFR1 in disease", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-HSA-1839117:r:Signaling by cytosolic FGFR1 fusion mutants"], "type": "Domain"}, "IPR057952": {"description": "Rv2743c-like", "go_ids": [], "go_terms": [], "name": "Rv2743c-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057953": {"description": "Suppressor APC domain-containing protein 2, N-terminal EF-hand-like domain", "go_ids": [], "go_terms": [], "name": "SAPC2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057954": {"description": "Tubulin--tyrosine ligase-like protein 12, SET-like domain", "go_ids": [], "go_terms": [], "name": "SET_TTL12", "pathway_ids": ["R-MMU-8955332", "R-HSA-8955332"], "pathways": ["R-MMU-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Domain"}, "IPR057955": {"description": "SF0329-like", "go_ids": [], "go_terms": [], "name": "SF0329-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057956": {"description": "Major coat protein VP4", "go_ids": [], "go_terms": [], "name": "SFV1_VP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057957": {"description": "Major coat protein VP5", "go_ids": [], "go_terms": [], "name": "SFV1_VP5", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057958": {"description": "SH3b_P2 domain", "go_ids": [], "go_terms": [], "name": "SH3b_P2_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057959": {"description": "Shotokuvirus capsid protein", "go_ids": [], "go_terms": [], "name": "Shotoku_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057960": {"description": "Skunalikevirus tail terminator", "go_ids": [], "go_terms": [], "name": "Skunalike_TailTerm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057961": {"description": "Gp41", "go_ids": [], "go_terms": [], "name": "Gp41", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057962": {"description": "SPT23/MGA2-like, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "SPT23_MGA2_DBD", "pathway_ids": ["R-SCE-8948751"], "pathways": ["R-SCE-8948751:r:Regulation of PTEN stability and activity"], "type": "Domain"}, "IPR057963": {"description": "Capsid protein VP10", "go_ids": [], "go_terms": [], "name": "SPV1_VP10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057964": {"description": "Major capsid protein VP4", "go_ids": [], "go_terms": [], "name": "SPV1_VP4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057965": {"description": "STEEP1 domain", "go_ids": [], "go_terms": [], "name": "STEEP1_dom", "pathway_ids": ["R-DRE-72163", "R-HSA-72163", "R-DME-72163", "R-XTR-72163", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-XTR-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR057966": {"description": "Capsid assembly scaffolding protein, T4-phage", "go_ids": [], "go_terms": [], "name": "T4_SCAF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057967": {"description": "Tape measure protein-like", "go_ids": [], "go_terms": [], "name": "T4_TMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057968": {"description": "Phage T4 Y03C-like", "go_ids": [], "go_terms": [], "name": "T4_Y03C-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057969": {"description": "Bacteriophage T4 Y13H-like", "go_ids": [], "go_terms": [], "name": "T4_Y13H-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057970": {"description": "Tail completion protein p143", "go_ids": [], "go_terms": [], "name": "T5_p143", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057971": {"description": "Pleckstrin homology domain-containing family A member 4-7, TBCA domain", 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"R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants"], "type": "Domain"}, "IPR057975": {"description": "Anaphase-promoting complex subunit 2, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_ANAPC2", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-SPO-176408", "R-HSA-2467813", "R-MMU-2467813", "R-MMU-174154", "R-MMU-69017", "R-MMU-179409", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-CEL-983168", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-DDI-176409", "R-DDI-2559582", "R-DDI-2467813", "R-SPO-983168", "R-DDI-176412", "R-SCE-983168", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-68867", "R-DDI-174084", "R-MMU-176409", "R-SPO-2559582", "R-HSA-176409", "R-HSA-9687136", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-SPO-179409", "R-DDI-174048", 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targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 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{"description": "NAA35-like, N-terminal", "go_ids": [], "go_terms": [], "name": "NAA35-like_N", "pathway_ids": ["R-HSA-6811440"], "pathways": ["R-HSA-6811440:r:Retrograde transport at the Trans-Golgi-Network"], "type": "Domain"}, "IPR057984": {"description": "PATROL1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "PATROL1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057985": {"description": "26S proteasome non-ATPase regulatory subunit 3, N-terminal TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_PSMD3_N", "pathway_ids": ["R-BTA-69601", "R-DME-2467813", "R-HSA-8854050", "R-DME-5676590", "R-BTA-5607761", "R-HSA-450408", "R-HSA-5610783", "R-SCE-5689880", "R-MMU-174084", "R-HSA-211733", "R-BTA-68867", "R-HSA-1234176", "R-DDI-6798695", "R-HSA-9931269", "R-HSA-5607761", "R-HSA-9929491", "R-MMU-68867", "R-DME-4641257", "R-DME-432524", "R-DDI-174084", "R-MMU-9932298", "R-DME-209461", "R-MMU-1234176", "R-MMU-4641258", "R-DME-75815", "R-DDI-4641258", 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"R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-SCE-5689880:r:Ub-specific processing proteases", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-211733:r:Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-BTA-68867:r:Assembly of the pre-replicative complex", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-DME-4641257:r:Degradation of AXIN", "R-DME-432524:r:Degradation of PER", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-9932298:r:Degradation of CRY and PER proteins", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DME-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-4641258:r:Degradation of DVL", "R-BTA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-180534:r:Vpu mediated degradation of CD4", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DME-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-CEL-8948751:r:Regulation of PTEN stability and activity", "R-CEL-4608870:r:Asymmetric localization of PCP proteins", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-4641257:r:Degradation of AXIN", "R-MMU-9766229:r:Degradation of CDH1", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-BTA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DME-202424:r:Downstream TCR signaling", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-382556:r:ABC-family proteins mediated transport", "R-BTA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-BTA-68949:r:Orc1 removal from chromatin", "R-SCE-6798695:r:Neutrophil degranulation", "R-MMU-68949:r:Orc1 removal from chromatin", "R-CEL-9907900:r:Proteasome assembly", "R-HSA-9824272:r:Somitogenesis", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-4608870:r:Asymmetric localization of PCP proteins", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-MMU-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-9907900:r:Proteasome assembly", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DME-9907900:r:Proteasome assembly", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-5689603:r:UCH proteinases", "R-CEL-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DME-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-DDI-5689880:r:Ub-specific processing proteases", "R-MMU-202424:r:Downstream TCR signaling", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-382556:r:ABC-family proteins mediated transport", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-DME-209360:r:Ubiquitination and proteolysis of phosphorylated CI", "R-BTA-5632684:r:Hedgehog 'on' state", "R-DDI-5687128:r:MAPK6/MAPK4 signaling", "R-BTA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-BTA-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-CEL-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-6798695:r:Neutrophil degranulation", "R-DDI-9907900:r:Proteasome assembly", "R-SCE-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-DME-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-DME-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-DME-432626:r:Circadian Clock pathway", "R-BTA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DME-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689880:r:Ub-specific processing proteases", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-8939902:r:Regulation of RUNX2 expression and activity", "R-DME-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-9932298:r:Degradation of CRY and PER proteins", "R-BTA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-9020702:r:Interleukin-1 signaling", "R-HSA-8939236:r:RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-CEL-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-SPO-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-5358346:r:Hedgehog ligand biogenesis", "R-DME-5689880:r:Ub-specific processing proteases", "R-CEL-8951664:r:Neddylation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-8854050:r:FBXL7 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"R-BTA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-DME-8939902:r:Regulation of RUNX2 expression and activity", "R-CEL-5689603:r:UCH proteinases", "R-CEL-382556:r:ABC-family proteins mediated transport", "R-HSA-4641257:r:Degradation of AXIN", "R-MMU-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-MMU-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-BTA-9932298:r:Degradation of CRY and PER proteins", "R-BTA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-4608870:r:Asymmetric localization of PCP proteins", "R-SCE-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-MMU-9907900:r:Proteasome assembly", "R-DME-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-69481:r:G2/M Checkpoints", "R-DME-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-CEL-4641258:r:Degradation of DVL", "R-BTA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-5658442:r:Regulation of RAS by GAPs", "R-BTA-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-5687128:r:MAPK6/MAPK4 signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-DDI-8948751:r:Regulation of PTEN stability and activity", "R-HSA-5678895:r:Defective CFTR causes cystic fibrosis", "R-BTA-5358346:r:Hedgehog ligand biogenesis", "R-HSA-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-4641258:r:Degradation of DVL", "R-CEL-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-5689603:r:UCH proteinases", "R-DME-9755511:r:KEAP1-NFE2L2 pathway", "R-DME-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-SPO-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-BTA-4641258:r:Degradation of DVL", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-CEL-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5658442:r:Regulation of RAS by GAPs", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-MMU-4641257:r:Degradation of AXIN", "R-BTA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-MMU-9931269:r:AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-DDI-68949:r:Orc1 removal from chromatin", "R-DME-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-8948751:r:Regulation of PTEN stability and activity", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-5689603:r:UCH proteinases", "R-DME-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-209406:r:Degradation of NF-kappa-B inhibitor, CACT", "R-DME-2871837:r:FCERI mediated NF-kB activation", "R-DME-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-8939902:r:Regulation of RUNX2 expression and activity", "R-BTA-9766229:r:Degradation of CDH1", "R-DME-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-8951664:r:Neddylation", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-MMU-5610780:r:Degradation of GLI1 by the proteasome", "R-DME-1169091:r:Activation of NF-kappaB in B cells", "R-DME-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DDI-9755511:r:KEAP1-NFE2L2 pathway", "R-BTA-382556:r:ABC-family proteins mediated transport", "R-DME-382556:r:ABC-family proteins mediated transport", "R-HSA-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-DME-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8941858:r:Regulation of RUNX3 expression and activity", "R-DME-4641258:r:Degradation of DVL", "R-CEL-8939902:r:Regulation of RUNX2 expression and activity", "R-MMU-9755511:r:KEAP1-NFE2L2 pathway", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-MMU-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-DME-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DDI-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-2467813:r:Separation of Sister Chromatids", "R-MMU-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-5689603:r:UCH proteinases", "R-DME-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5658442:r:Regulation of RAS by GAPs", "R-MMU-5689603:r:UCH proteinases", "R-DME-216167:r:Nuclear CI is degraded", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-DDI-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-MMU-4608870:r:Asymmetric localization of PCP proteins", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DME-68949:r:Orc1 removal from chromatin", "R-BTA-9907900:r:Proteasome assembly", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-BTA-5610780:r:Degradation of GLI1 by the proteasome", "R-BTA-8948751:r:Regulation of PTEN stability and activity", "R-CEL-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-9954709:r:Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-382556:r:ABC-family proteins mediated transport", "R-HSA-8852276:r:The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5632684:r:Hedgehog 'on' state", "R-BTA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-DME-538864:r:Degradation of CRY", "R-SCE-9907900:r:Proteasome assembly", "R-HSA-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9929356:r:GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-CEL-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-CEL-68949:r:Orc1 removal from chromatin", "R-DME-432395:r:Degradation of TIM", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-349425:r:Autodegradation of the E3 ubiquitin ligase COP1", "R-BTA-9020702:r:Interleukin-1 signaling", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DDI-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-BTA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-1236978:r:Cross-presentation of soluble exogenous antigens (endosomes)", "R-CEL-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-HSA-202424:r:Downstream TCR signaling", "R-BTA-5689603:r:UCH proteinases", "R-CEL-4641257:r:Degradation of AXIN", "R-DME-68867:r:Assembly of the pre-replicative complex", "R-MMU-450408:r:AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-BTA-5689880:r:Ub-specific processing proteases", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-5689880:r:Ub-specific processing proteases", "R-HSA-8951664:r:Neddylation", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DME-5658442:r:Regulation of RAS by GAPs", "R-CEL-8941858:r:Regulation of RUNX3 expression and activity", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-BTA-9755511:r:KEAP1-NFE2L2 pathway", "R-MMU-8948751:r:Regulation of PTEN stability and activity", "R-DME-8948751:r:Regulation of PTEN stability and activity", "R-MMU-69481:r:G2/M Checkpoints", "R-BTA-350562:r:Regulation of ornithine decarboxylase (ODC)", "R-SPO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-BTA-75815:r:Ubiquitin-dependent degradation of Cyclin D", "R-BTA-1169091:r:Activation of NF-kappaB in B cells", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-5668541:r:TNFR2 non-canonical NF-kB pathway", "R-BTA-69481:r:G2/M Checkpoints"], "type": "Domain"}, "IPR057986": {"description": "Zinc finger protein Rlf/292/654, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_Rlf/292/654", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057987": {"description": "E3 ubiquitin-protein ligase RNF123/RKP, TPR repeat", "go_ids": [], "go_terms": [], "name": "TPR_RNF123/RKP", "pathway_ids": ["PWY-7511", "R-MMU-5689880", "R-HSA-983168", "R-RNO-983168", "R-HSA-5689880", "R-RNO-5689880", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR057988": {"description": "PBCV-1 P7, disulphide-bonded domain", "go_ids": [], "go_terms": [], "name": "PBCV1_P7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057989": {"description": "RPAP1/MINIYO-like, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_RPAP1/MINIYO-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057990": {"description": "SYO1-like, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_SYO1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057991": {"description": "Transcription initiation factor TFIID subunit 2, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_TAF2_C", "pathway_ids": ["R-CEL-73779", "R-SPO-674695", "R-MMU-75953", "R-SCE-75953", "R-DRE-73779", "R-DME-76042", "R-MMU-6804756", "R-DME-73779", "R-DRE-75953", "R-HSA-167162", "R-DME-73776", "R-SPO-76042", "R-HSA-73776", "R-HSA-75953", "R-CEL-75953", "R-MMU-73776", "R-DME-75953", "R-MMU-73779", "R-HSA-167172", "R-CEL-73776", "R-MMU-76042", "R-SPO-75953", "R-SCE-73779", "R-DRE-6804756", "R-DRE-76042", "R-DME-674695", "R-DRE-73776", "R-MMU-674695", "R-SCE-76042", "R-DME-6804756", "R-HSA-167161", "R-CEL-674695", "R-HSA-6804756", "R-DRE-674695", "R-SCE-674695", "R-SPO-73779", "R-HSA-76042", "R-HSA-674695", "R-SPO-73776", "R-CEL-76042", "R-HSA-73779", "R-SCE-73776"], "pathways": ["R-CEL-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SPO-674695:r:RNA Polymerase II Pre-transcription Events", "R-MMU-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-75953:r:RNA Polymerase II Transcription Initiation", "R-DRE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DME-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DME-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-75953:r:RNA Polymerase II Transcription Initiation", "R-HSA-167162:r:RNA Polymerase II HIV Promoter Escape", "R-DME-73776:r:RNA Polymerase II Promoter Escape", "R-SPO-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73776:r:RNA Polymerase II Promoter Escape", "R-HSA-75953:r:RNA Polymerase II Transcription Initiation", "R-CEL-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73776:r:RNA Polymerase II Promoter Escape", "R-DME-75953:r:RNA Polymerase II Transcription Initiation", "R-MMU-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-167172:r:Transcription of the HIV genome", "R-CEL-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-SPO-75953:r:RNA Polymerase II Transcription Initiation", "R-SCE-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-DRE-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-674695:r:RNA Polymerase II Pre-transcription Events", "R-DRE-73776:r:RNA Polymerase II Promoter Escape", "R-MMU-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-DME-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-167161:r:HIV Transcription Initiation", "R-CEL-674695:r:RNA Polymerase II Pre-transcription Events", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-DRE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-HSA-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-674695:r:RNA Polymerase II Pre-transcription Events", "R-SPO-73776:r:RNA Polymerase II Promoter Escape", "R-CEL-76042:r:RNA Polymerase II Transcription Initiation And Promoter Clearance", "R-HSA-73779:r:RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "R-SCE-73776:r:RNA Polymerase II Promoter Escape"], "type": "Domain"}, "IPR057992": {"description": "E3 ubiquitin-protein ligase synoviolin-like, TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_SYVN1_N", "pathway_ids": ["PWY-7511", "R-HSA-532668", "R-HSA-381038", "R-DRE-5358346", "R-HSA-901032", "R-MMU-5358346", "R-DRE-532668", "R-HSA-5362768", "R-MMU-532668", "R-DME-5358346", "R-CEL-5358346", "R-HSA-5358346"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DRE-5358346:r:Hedgehog ligand biogenesis", "R-HSA-901032:r:ER Quality Control Compartment (ERQC)", "R-MMU-5358346:r:Hedgehog ligand biogenesis", "R-DRE-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-HSA-5362768:r:Hh mutants are degraded by ERAD", "R-MMU-532668:r:N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "R-DME-5358346:r:Hedgehog ligand biogenesis", "R-CEL-5358346:r:Hedgehog ligand biogenesis", "R-HSA-5358346:r:Hedgehog ligand biogenesis"], "type": "Domain"}, "IPR057993": {"description": "HD-Zip IV, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HD-Zip_IV_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057994": {"description": "Major capsid protein 1, PFV", "go_ids": [], "go_terms": [], "name": "PFV_capsid", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057995": {"description": "Gp11, Phage 80a", "go_ids": [], "go_terms": [], "name": "Phage_80a_gp11", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057996": {"description": "Depolymerase 2 capsule K5-specific, C-terminal domain", "go_ids": [], "go_terms": [], "name": "K52_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR057997": {"description": "Gp33 protein", "go_ids": [], "go_terms": [], "name": "Gp33", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057998": {"description": "Gp168", "go_ids": [], "go_terms": [], "name": "Gp168", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR057999": {"description": "Gp49", "go_ids": [], "go_terms": [], "name": "Gp49", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058000": {"description": "Gp58, bacteriophage", "go_ids": [], "go_terms": [], "name": "Gp58_bacteriophage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058001": {"description": "Head completion protein 1", "go_ids": [], "go_terms": [], "name": "HCP1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058002": {"description": "Gp82", "go_ids": [], "go_terms": [], "name": "Gp82", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058003": {"description": "Tail tubular protein gp12", "go_ids": [], "go_terms": [], "name": "Phage_gp12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058004": {"description": "ORF43.1", "go_ids": [], "go_terms": [], "name": "ORF43.1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058005": {"description": "Repressor protein C", "go_ids": [], "go_terms": [], "name": "Repressor_C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058006": {"description": "1.05 protein", "go_ids": [], "go_terms": [], "name": "1.05", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058007": {"description": "Gp5.9", "go_ids": [], "go_terms": [], "name": "Gp5.9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058008": {"description": "Phage tail protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gp26_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058009": {"description": "Tail tube protein, phage 16", "go_ids": [], "go_terms": [], "name": "TTP_Phage_16", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058010": {"description": "Y01A", "go_ids": [], "go_terms": [], "name": "Y01A", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058011": {"description": "Major capsid protein, Phi29", "go_ids": [], "go_terms": [], "name": "Phi29_MCP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058012": {"description": "Major outer capsid P8", "go_ids": [], "go_terms": [], "name": "MOCP_P8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058013": {"description": "Gp119", "go_ids": [], "go_terms": [], "name": "Gp119", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058014": {"description": "Gp244", "go_ids": [], "go_terms": [], "name": "Gp244", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058015": {"description": "PHIKZ035", "go_ids": [], "go_terms": [], "name": "PHIKZ035", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058016": {"description": "Gp85", "go_ids": [], "go_terms": [], "name": "Gp85", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058017": {"description": "AAA+ ATPase At3g28540-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "At3g28540-like_C", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", 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"R-DME-77595", "R-SPO-159231", "R-MMU-77595", "R-DME-159231", "R-DDI-9770562", "R-CEL-73856", "R-CEL-77595", "R-HSA-77595", "R-DME-9770562", "R-MMU-6781823", "R-DRE-73856", "R-GGA-353303", "R-DRE-9770562", "R-HSA-6782210", "R-HSA-72165", "R-HSA-9918481", "R-MMU-159231", "R-MMU-5696400", "R-BTA-72165", "R-HSA-9770562", "R-RNO-6782135", "R-HSA-6782135", "R-DME-5696395", "R-MMU-72187", "R-SPO-5696400", "R-MMU-72165", "R-DME-5696400", "R-SPO-6782210", "R-RNO-5696400", "R-HSA-5696400", "R-DME-6782210", "R-SPO-6782135", "R-DRE-72165", "R-CEL-8951664"], "pathways": ["R-RNO-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-CEL-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-9770562:r:mRNA Polyadenylation", "R-HSA-8951664:r:Neddylation", "R-DME-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DME-8951664:r:Neddylation", "R-HSA-73856:r:RNA Polymerase II Transcription Termination", "R-DME-72163:r:mRNA Splicing - Major Pathway", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72187:r:mRNA 3'-end processing", "R-RNO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DME-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-8951664:r:Neddylation", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-8951664:r:Neddylation", "R-SPO-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-9770562:r:mRNA Polyadenylation", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-DME-6782135:r:Dual incision in TC-NER", "R-RNO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-BTA-72163:r:mRNA Splicing - Major Pathway", "R-DRE-77595:r:Processing of Intronless Pre-mRNAs", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-SCE-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-RNO-5696395:r:Formation of Incision Complex in GG-NER", "R-DDI-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-MMU-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-77595:r:Processing of Intronless Pre-mRNAs", "R-RNO-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-CEL-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SPO-9770562:r:mRNA Polyadenylation", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-DME-72165:r:mRNA Splicing - Minor Pathway", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-RNO-8951664:r:Neddylation", "R-BTA-9770562:r:mRNA Polyadenylation", "R-SPO-8951664:r:Neddylation", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-6782135:r:Dual incision in TC-NER", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-DME-77595:r:Processing of Intronless Pre-mRNAs", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DDI-9770562:r:mRNA Polyadenylation", "R-CEL-73856:r:RNA Polymerase II Transcription Termination", "R-CEL-77595:r:Processing of Intronless Pre-mRNAs", "R-HSA-77595:r:Processing of Intronless Pre-mRNAs", "R-DME-9770562:r:mRNA Polyadenylation", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DRE-73856:r:RNA Polymerase II Transcription Termination", "R-GGA-353303:r:Nucleotide Excision Repair", "R-DRE-9770562:r:mRNA Polyadenylation", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-BTA-72165:r:mRNA Splicing - Minor Pathway", "R-HSA-9770562:r:mRNA Polyadenylation", "R-RNO-6782135:r:Dual incision in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-DME-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-72187:r:mRNA 3'-end processing", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-MMU-72165:r:mRNA Splicing - Minor Pathway", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-RNO-5696400:r:Dual Incision in GG-NER", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-DME-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-DRE-72165:r:mRNA Splicing - Minor Pathway", "R-CEL-8951664:r:Neddylation"], "type": "Domain"}, "IPR058544": {"description": "Ethylene receptor 1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ETR1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058545": {"description": "EMC1, first beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_EMC1_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058546": {"description": "Disease resistance protein RPS4B/Roq1-like, leucine-rich repeats", "go_ids": [], "go_terms": [], "name": "RPS4B/Roq1-like_LRR", "pathway_ids": ["PWY-5381"], "pathways": ["PWY-5381:t:NAD salvage (plants)"], "type": "Domain"}, "IPR058547": {"description": "Pelota, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Pelota_N", "pathway_ids": ["R-DRE-9954714", "R-DME-9954714", "R-SPO-9954714", "R-SCE-9954714", "R-CEL-9954714", "R-RNO-9954714", "R-MMU-9954714", "R-HSA-9954714"], "pathways": ["R-DRE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-DME-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SPO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-SCE-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-CEL-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-RNO-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-MMU-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "R-HSA-9954714:r:PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "type": "Domain"}, "IPR058550": {"description": "Plasmid partition protein, putative, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Plasmid_parti_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058551": {"description": "Plasmid partition protein, putative, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Plasmid_parti_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058552": {"description": "V(D)J recombination-activating protein 1, DNA-binding domain", "go_ids": [], "go_terms": [], "name": "RAG1_DNA-bd", "pathway_ids": ["PWY-7511", "R-HSA-1266695", "R-HSA-5687128"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Domain"}, "IPR058553": {"description": "V(D)J recombination-activating protein 1, pre-RNase H domain", "go_ids": [], "go_terms": [], "name": "RAG1_pre-RNase_H", "pathway_ids": ["PWY-7511", "R-HSA-1266695", "R-HSA-5687128"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Domain"}, "IPR058554": {"description": "V(D)J recombination-activating protein 1, RNase H domain", "go_ids": [], "go_terms": [], "name": "RAG1_RNase_H", "pathway_ids": ["PWY-7511", "R-HSA-1266695", "R-HSA-5687128"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Domain"}, "IPR058555": {"description": "V(D)J recombination-activating protein 1, ZnC2 domain", "go_ids": [], "go_terms": [], "name": "RAG1_ZnC2", "pathway_ids": ["R-HSA-1266695", "R-HSA-5687128", "PWY-7511"], "pathways": ["R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR058556": {"description": "V(D)J recombination-activating protein 1, ZnH2 domain", "go_ids": [], "go_terms": [], "name": "RAG1_ZnH2", "pathway_ids": ["PWY-7511", "R-HSA-1266695", "R-HSA-5687128"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Domain"}, "IPR058557": {"description": "V(D)J recombination-activating protein 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RAG1_C", "pathway_ids": ["PWY-7511", "R-HSA-1266695", "R-HSA-5687128"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-1266695:r:Interleukin-7 signaling", "R-HSA-5687128:r:MAPK6/MAPK4 signaling"], "type": "Domain"}, "IPR058559": {"description": "STIL, proline-rich motif", "go_ids": [], "go_terms": [], "name": "PRM_STIL", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR058560": {"description": "DNA primase, large subunit C-terminal domain, eukaryotic and archaeal", "go_ids": [], "go_terms": [], "name": "DNA_primase_C", "pathway_ids": ["R-MMU-174430", "R-CEL-69091", "R-RNO-68962", "R-CEL-68962", "R-SCE-69091", "R-CEL-113501", "R-CEL-69166", "R-DME-113501", "R-RNO-69183", "R-DDI-68952", "R-RNO-69166", "R-DME-68962", "R-DDI-68962", "R-CEL-69183", "R-SPO-69091", "R-DME-69183", "R-HSA-68962", "R-DME-68952", "R-RNO-68952", "R-RNO-174411", "R-SCE-68952", "R-SPO-69166", "R-HSA-113501", "R-SCE-69183", "R-HSA-68952", "R-DDI-113501", "R-DDI-69091", "R-MMU-68962", "R-DDI-69183", "R-RNO-174430", "R-SPO-69183", "R-HSA-174430", "R-MMU-113501", "R-DME-69091", "R-HSA-174411", "R-HSA-69166", "R-MMU-69183", "R-SCE-68962", "R-SCE-113501", "R-DDI-69166", "R-RNO-69091", "R-HSA-9710421", "R-MMU-68952", "R-RNO-113501", "R-SPO-113501", "R-SPO-68952", "R-CEL-68952", "R-SCE-69166", "R-MMU-69166", "R-HSA-69183", "R-SPO-68962", "R-HSA-69091", "R-MMU-174411", "R-MMU-69091", "R-DME-69166"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-CEL-69091:r:Polymerase switching", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-CEL-68962:r:Activation of the pre-replicative complex", "R-SCE-69091:r:Polymerase switching", "R-CEL-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-CEL-69166:r:Removal of the Flap Intermediate", "R-DME-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-RNO-69183:r:Processive synthesis on the lagging strand", "R-DDI-68952:r:DNA replication initiation", "R-RNO-69166:r:Removal of the Flap Intermediate", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-CEL-69183:r:Processive synthesis on the lagging strand", "R-SPO-69091:r:Polymerase switching", "R-DME-69183:r:Processive synthesis on the lagging strand", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-DME-68952:r:DNA replication initiation", "R-RNO-68952:r:DNA replication initiation", "R-RNO-174411:r:Polymerase switching on the C-strand of the telomere", "R-SCE-68952:r:DNA replication initiation", "R-SPO-69166:r:Removal of the Flap Intermediate", "R-HSA-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SCE-69183:r:Processive synthesis on the lagging strand", "R-HSA-68952:r:DNA replication initiation", "R-DDI-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DDI-69091:r:Polymerase switching", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-DDI-69183:r:Processive synthesis on the lagging strand", "R-RNO-174430:r:Telomere C-strand synthesis initiation", "R-SPO-69183:r:Processive synthesis on the lagging strand", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-MMU-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DME-69091:r:Polymerase switching", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-69166:r:Removal of the Flap Intermediate", "R-MMU-69183:r:Processive synthesis on the lagging strand", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-SCE-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-DDI-69166:r:Removal of the Flap Intermediate", "R-RNO-69091:r:Polymerase switching", "R-HSA-9710421:r:Defective pyroptosis", "R-MMU-68952:r:DNA replication initiation", "R-RNO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-113501:r:Inhibition of replication initiation of damaged DNA by RB1/E2F1", "R-SPO-68952:r:DNA replication initiation", "R-CEL-68952:r:DNA replication initiation", "R-SCE-69166:r:Removal of the Flap Intermediate", "R-MMU-69166:r:Removal of the Flap Intermediate", "R-HSA-69183:r:Processive synthesis on the lagging strand", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-69091:r:Polymerase switching", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-69091:r:Polymerase switching", "R-DME-69166:r:Removal of the Flap Intermediate"], "type": "Domain"}, "IPR058561": {"description": "Exonuclease I, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Exonuc_1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058562": {"description": "MJ0586, N-terminal zinc binding domain", "go_ids": [], "go_terms": [], "name": "MJ0586_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058563": {"description": "Trs120/TRAPPC9, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Trs120_TRAPPC9_N", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-MMU-8876198", "R-DME-8876198", "R-SCE-204005", "R-SPO-204005", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198", "R-DME-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR058564": {"description": "Trs120/TRAPPC9, TPR region", "go_ids": [], "go_terms": [], "name": "TPR_TRAPPC9_Trs120", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-MMU-8876198", "R-DME-8876198", "R-SCE-204005", "R-SPO-204005", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198", "R-DME-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR058565": {"description": "Trs120/TRAPPC9, first Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TRAPPC9_Trs120_1st", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-MMU-8876198", "R-DME-8876198", "R-SCE-204005", "R-SPO-204005", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198", "R-DME-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR058567": {"description": "Trs120/TRAPPC9, third Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TRAPPC9_Trs120_3rd", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-MMU-8876198", "R-DME-8876198", "R-SCE-204005", "R-SPO-204005", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198", "R-DME-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR058568": {"description": "Trs120/TRAPPC9, fourth Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TRAPPC9_Trs120_4th", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-MMU-8876198", "R-DME-8876198", "R-SCE-204005", "R-SPO-204005", "R-HSA-8876198", "R-SPO-8876198", "R-SCE-8876198", "R-DME-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SPO-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-SCE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR058569": {"description": "DUF6079, second domain", "go_ids": [], "go_terms": [], "name": "DUF6079_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058570": {"description": "Homologous recombination OB-fold protein, OB-fold domain", "go_ids": [], "go_terms": [], "name": "HROB_OB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058571": {"description": "DUF6079, third domain", "go_ids": [], "go_terms": [], "name": "DUF6079_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058572": {"description": "DUF6079, fourth domain", "go_ids": [], "go_terms": [], "name": "DUF6079_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058573": {"description": "DUF6079, fifth domain", "go_ids": [], "go_terms": [], "name": "DUF6079_5th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058574": {"description": "DUF6079, sixth domain", "go_ids": [], "go_terms": [], "name": "DUF6079_6th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058575": {"description": "Nucleotidyltransferase-like domain, bacterial", "go_ids": [], "go_terms": [], "name": "NTP_transf_8_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058577": {"description": "DUF7855, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF7855_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058578": {"description": "IspG, TIM-barrel domain", "go_ids": [], "go_terms": [], "name": "IspG_TIM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058579": {"description": "IspG, C-terminal domain", "go_ids": [], "go_terms": [], "name": "IspG_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058580": {"description": "Domain of unknown function DUF2828", "go_ids": [], "go_terms": [], "name": "DUF2828", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058581": {"description": "HPP, transmembrane region", "go_ids": [], "go_terms": [], "name": "TM_HPP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058582": {"description": "NusA-like, second KH domain", "go_ids": [], "go_terms": [], "name": "KH_NusA_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058583": {"description": "Non-toxic nonhemagglutinin", "go_ids": ["GO:0004222", "GO:0006508", "GO:0008270"], "go_terms": ["GO:0004222:metalloendopeptidase activity:F", "GO:0006508:proteolysis:P", "GO:0008270:zinc ion binding:F"], "name": "NTNH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058584": {"description": "Importin subunit beta-1/Transportin-1-like, TPR repeats", "go_ids": [], "go_terms": [], "name": "IMB1_TNPO1-like_TPR", "pathway_ids": ["R-HSA-6798695", "R-SPO-6798695", "R-SPO-68616", "R-RNO-2995383", "R-DDI-165159", "R-DME-2995383", "R-SPO-2995383", "R-SCE-6798695", "R-HSA-1169408", "R-SCE-2995383", "R-DDI-6804757", "R-RNO-1655829", "R-RNO-140342", "R-HSA-68616", "R-HSA-9828806", "R-RNO-68616", "R-HSA-192905", "R-DDI-5218920", "R-MMU-909733", "R-MMU-1655829", "R-MMU-2995383", "R-MMU-5620924", "R-HSA-140342", "R-HSA-1655829", "R-DDI-9639288", "R-DDI-5628897", "R-HSA-9636249", "R-DDI-1632852", "R-HSA-5620924", "R-HSA-168276", "R-HSA-168271", "R-DME-909733", "R-DME-6798695", "R-HSA-9918432", "R-BTA-450513", "R-DDI-1257604", "R-DDI-166208", "R-HSA-2995383", "R-DDI-380972", "R-DDI-3371571", "R-DME-68616", "R-DDI-8943724", "R-MMU-140342", "R-HSA-9615933", "R-DDI-9856530", "R-MMU-450513", "R-HSA-909733", "R-RNO-909733", "R-DME-1655829", "R-HSA-9692916", "R-HSA-450513", "R-DDI-389357", "R-MMU-6798695", "R-DME-140342", "R-MMU-68616", "R-HSA-180746", "R-RNO-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-SPO-6798695:r:Neutrophil degranulation", "R-SPO-68616:r:Assembly of the ORC complex at the origin of replication", "R-RNO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-165159:r:MTOR signalling", "R-DME-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SPO-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-SCE-6798695:r:Neutrophil degranulation", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-SCE-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-6804757:r:Regulation of TP53 Degradation", "R-RNO-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-RNO-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-RNO-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-192905:r:vRNP Assembly", "R-DDI-5218920:r:VEGFR2 mediated vascular permeability", "R-MMU-909733:r:Interferon alpha/beta signaling", "R-MMU-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-MMU-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-MMU-5620924:r:Intraflagellar transport", "R-HSA-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-DDI-9639288:r:Amino acids regulate mTORC1", "R-DDI-5628897:r:TP53 Regulates Metabolic Genes", "R-HSA-9636249:r:Inhibition of nitric oxide production", "R-DDI-1632852:r:Macroautophagy", "R-HSA-5620924:r:Intraflagellar transport", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-DME-909733:r:Interferon alpha/beta signaling", "R-DME-6798695:r:Neutrophil degranulation", "R-HSA-9918432:r:Maturation of DENV proteins", "R-BTA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DDI-1257604:r:PIP3 activates AKT signaling", "R-DDI-166208:r:mTORC1-mediated signalling", "R-HSA-2995383:r:Initiation of Nuclear Envelope (NE) Reformation", "R-DDI-380972:r:Energy dependent regulation of mTOR by LKB1-AMPK", "R-DDI-3371571:r:HSF1-dependent transactivation", "R-DME-68616:r:Assembly of the ORC complex at the origin of replication", "R-DDI-8943724:r:Regulation of PTEN gene transcription", "R-MMU-140342:r:Apoptosis induced DNA fragmentation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DDI-9856530:r:High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-MMU-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-HSA-909733:r:Interferon alpha/beta signaling", "R-RNO-909733:r:Interferon alpha/beta signaling", "R-DME-1655829:r:Regulation of cholesterol biosynthesis by SREBP (SREBF)", "R-HSA-9692916:r:SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-450513:r:Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "R-DDI-389357:r:CD28 dependent PI3K/Akt signaling", "R-MMU-6798695:r:Neutrophil degranulation", "R-DME-140342:r:Apoptosis induced DNA fragmentation", "R-MMU-68616:r:Assembly of the ORC complex at the origin of replication", "R-HSA-180746:r:Nuclear import of Rev protein", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR058585": {"description": "VIN3-like, fibronectin type-III domain", "go_ids": [], "go_terms": [], "name": "Fn3_VIN3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058586": {"description": "Apical junction molecule ajm1, alpha/beta domain", "go_ids": [], "go_terms": [], "name": "Ajm-1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058587": {"description": "Chaperone protein CcmS", "go_ids": [], "go_terms": [], "name": "CcmS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058588": {"description": "Type II CBASS E2 protein", "go_ids": [], "go_terms": [], "name": "E2-CBASS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058589": {"description": "Endo-alpha(1,4)-fucoidanase Mef1", "go_ids": [], "go_terms": [], "name": "Mef1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058590": {"description": "Tle-like phospholipase domain", "go_ids": [], "go_terms": [], "name": "Tle-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058591": {"description": "Glucosyltransferase 3-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Gtf3_N", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR058592": {"description": "Glucosyltransferase 3-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Gtf3_C", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR058593": {"description": "ARB_07466-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ARB_07466-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058594": {"description": "PB1-like domain, plants", "go_ids": [], "go_terms": 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"Homing endonuclease-like", "go_ids": [], "go_terms": [], "name": "Homing_endonuclease-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058750": {"description": "Epg5-like, TPR", "go_ids": [], "go_terms": [], "name": "TPR_Epg5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058751": {"description": "RDRP, helical domain", "go_ids": [], "go_terms": [], "name": "RDRP_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058752": {"description": "RDRP, C-terminal head domain", "go_ids": [], "go_terms": [], "name": "RDRP_C_head", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058753": {"description": "Otogelin-like/Mucin, TIL domain", "go_ids": [], "go_terms": [], "name": "TIL_OTOGL_Mucin", "pathway_ids": ["R-HSA-5083632", "R-HSA-5674135", "R-MMU-5674135", "R-HSA-6802952", "R-HSA-9845620", "R-HSA-977068", "R-MMU-913709", "R-HSA-140837", "R-HSA-430116", "R-MMU-76009", "R-MMU-430116", "R-HSA-9845622", "R-HSA-9845621", "R-MMU-372708", "R-HSA-114608", "R-HSA-76009", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-9846298", "R-HSA-5083625", "R-HSA-9672391", "R-MMU-977068", "R-HSA-5621480", "R-HSA-6802955", "R-HSA-9672393", "R-HSA-354192", "R-HSA-5083636", "R-HSA-6802948", "R-HSA-216083", "R-HSA-9662361", "R-MMU-140837", "R-HSA-9845619", "R-HSA-354194", "R-MMU-354194", "R-HSA-75892", "R-MMU-114608", "R-MMU-216083", "R-HSA-372708", "R-MMU-354192", "R-HSA-913709", "R-HSA-9656223"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-9845620:r:Enhanced binding of GP1BA variant to VWF multimer:collagen", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-430116:r:GP1b-IX-V activation signalling", "R-MMU-76009:r:Platelet Aggregation (Plug Formation)", "R-MMU-430116:r:GP1b-IX-V activation signalling", "R-HSA-9845622:r:Defective VWF binding to collagen type I", "R-HSA-9845621:r:Defective VWF cleavage by ADAMTS13 variant", "R-MMU-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-HSA-114608:r:Platelet degranulation", "R-HSA-76009:r:Platelet Aggregation (Plug Formation)", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9846298:r:Defective binding of VWF variant to GPIb:IX:V", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-HSA-9672391:r:Defective F8 cleavage by thrombin", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9672393:r:Defective F8 binding to von Willebrand factor", "R-HSA-354192:r:Integrin signaling", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-216083:r:Integrin cell surface interactions", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea", "R-MMU-140837:r:Intrinsic Pathway of Fibrin Clot Formation", "R-HSA-9845619:r:Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-MMU-354194:r:GRB2:SOS provides linkage to MAPK signaling for Integrins", "R-HSA-75892:r:Platelet Adhesion to exposed collagen", "R-MMU-114608:r:Platelet degranulation", "R-MMU-216083:r:Integrin cell surface interactions", "R-HSA-372708:r:p130Cas linkage to MAPK signaling for integrins", "R-MMU-354192:r:Integrin signaling", "R-HSA-913709:r:O-linked glycosylation of mucins", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Domain"}, "IPR058754": {"description": "Otogelin-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "OTOGL-like_N", "pathway_ids": ["R-HSA-9662361"], "pathways": ["R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR058755": {"description": "Otogelin-like, Fn1-VW hybrid domain", "go_ids": [], "go_terms": [], "name": "Fn1-VW_OTOGL", "pathway_ids": ["R-HSA-9662361"], "pathways": ["R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR058756": {"description": "Liposome tubulation protein MamY, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MamY_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058757": {"description": "UFSP2, N-terminal MPN-like domain", "go_ids": [], "go_terms": [], "name": "UFSP2_MPN_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058758": {"description": "E3 ubiquitin-protein ligase RNF216, UBA domain", "go_ids": [], "go_terms": [], "name": "UBA_RNF216", "pathway_ids": ["R-HSA-936440"], "pathways": ["R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling"], "type": "Domain"}, "IPR058759": {"description": "Pilin, mycobacteria", "go_ids": [], "go_terms": [], "name": "Pilin_mycobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058760": {"description": "RESC11-like", "go_ids": [], "go_terms": [], "name": "RESC11-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058761": {"description": "PhiTE adapter protein-like", "go_ids": [], "go_terms": [], "name": "PhiTE_adapter-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058762": {"description": "Collectin-12 domain", "go_ids": [], "go_terms": [], "name": "COLEC12_dom", "pathway_ids": ["R-HSA-198933", "R-HSA-3000480", "R-BTA-198933", "R-BTA-3000480"], "pathways": ["R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-BTA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-BTA-3000480:r:Scavenging by Class A Receptors"], "type": "Domain"}, "IPR058763": {"description": "RDR1/2-like, RRM domain", "go_ids": [], "go_terms": [], "name": "RRM_RDR1/2-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058764": {"description": "NPHP4, SK-like domain", "go_ids": [], "go_terms": [], "name": "NPHP4_SK", "pathway_ids": ["R-MMU-2028269", "R-HSA-2028269", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-2028269:r:Signaling by Hippo", "R-HSA-2028269:r:Signaling by Hippo", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR058765": {"description": "NPHP4, C2-like domain", "go_ids": [], "go_terms": [], "name": "NPHP4_C2-like", "pathway_ids": ["R-MMU-2028269", "R-HSA-2028269", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-2028269:r:Signaling by Hippo", "R-HSA-2028269:r:Signaling by Hippo", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR058766": {"description": "XRCC3/RAD51 homolog 2, helix-hairpin-helix domain", "go_ids": [], "go_terms": [], "name": "HHH_XRCC3_RAD51B", "pathway_ids": ["R-HSA-5685942", "R-HSA-9704331", "R-HSA-5693616", "R-HSA-5693579", "R-HSA-9704646", "R-HSA-983231", "R-MMU-5693568", "R-HSA-5693554", "R-HSA-9709603", "R-MMU-5693579", "R-MMU-983231", "R-MMU-5693616", "R-HSA-5693568", "R-MMU-5685942", "R-HSA-9701192"], "pathways": ["R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9704331:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-HSA-9704646:r:Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693554:r:Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-9709603:r:Impaired BRCA2 binding to PALB2", "R-MMU-5693579:r:Homologous DNA Pairing and Strand Exchange", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-5693568:r:Resolution of D-loop Structures through Holliday Junction Intermediates", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-9701192:r:Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "type": "Domain"}, "IPR058767": {"description": "MCM8, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MCM8_N", "pathway_ids": ["R-RNO-68949", "R-RNO-68689", "R-GGA-68689", "R-RNO-68962", "R-HSA-68949", "R-HSA-176974", "R-XTR-68689", "R-XTR-68962", "R-MMU-68962", "R-HSA-113507", "R-BTA-68949", "R-MMU-68949", "R-RNO-176187", "R-HSA-68689", "R-HSA-176187", "R-BTA-68962", "R-BTA-176187", "R-DME-68962", "R-DME-68689", "R-XTR-68949", "R-GGA-68949", "R-MMU-176187", "R-HSA-68962", "R-MMU-68689", "R-BTA-68689", "R-DME-68949", "R-GGA-176187", "R-DME-176187", "R-GGA-68962"], "pathways": ["R-RNO-68949:r:Orc1 removal from chromatin", "R-RNO-68689:r:CDC6 association with the ORC:origin complex", "R-GGA-68689:r:CDC6 association with the ORC:origin complex", "R-RNO-68962:r:Activation of the pre-replicative complex", "R-HSA-68949:r:Orc1 removal from chromatin", "R-HSA-176974:r:Unwinding of DNA", "R-XTR-68689:r:CDC6 association with the ORC:origin complex", "R-XTR-68962:r:Activation of the pre-replicative complex", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-HSA-113507:r:E2F-enabled inhibition of pre-replication complex formation", "R-BTA-68949:r:Orc1 removal from chromatin", "R-MMU-68949:r:Orc1 removal from chromatin", "R-RNO-176187:r:Activation of ATR in response to replication stress", "R-HSA-68689:r:CDC6 association with the ORC:origin complex", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-BTA-68962:r:Activation of the pre-replicative complex", "R-BTA-176187:r:Activation of ATR in response to replication stress", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DME-68689:r:CDC6 association with the ORC:origin complex", "R-XTR-68949:r:Orc1 removal from chromatin", "R-GGA-68949:r:Orc1 removal from chromatin", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-MMU-68689:r:CDC6 association with the ORC:origin complex", "R-BTA-68689:r:CDC6 association with the ORC:origin complex", "R-DME-68949:r:Orc1 removal from chromatin", "R-GGA-176187:r:Activation of ATR in response to replication stress", "R-DME-176187:r:Activation of ATR in response to replication stress", "R-GGA-68962:r:Activation of the pre-replicative complex"], "type": "Domain"}, "IPR058768": {"description": "MCM9, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MCM9_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058769": {"description": "MCMDC2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MCMDC2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058770": {"description": "ABCF3, PWI-like helical bundle domain", "go_ids": [], "go_terms": [], "name": "PWI_ABCF3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058771": {"description": "CCDC43, PWI-like domain", "go_ids": [], "go_terms": [], "name": "PWI_CCDC43", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058772": {"description": "ADGRG2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ADGRG2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058773": {"description": "Endo-beta-1,2-glucanase SGL", "go_ids": [], "go_terms": [], "name": "SGL_GH162", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058774": {"description": "RNA-editing substrate-binding complex 7 protein", "go_ids": [], "go_terms": [], "name": "RESC7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058775": {"description": "DUF8054, central domain", "go_ids": [], "go_terms": [], "name": "DUF8054_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058776": {"description": "Potassium/proton antiporter subunit KhtT-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "KhtT-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058777": {"description": "TXNDC11, thioredoxin-like domain", "go_ids": [], "go_terms": [], "name": "TXNDC11_thioredoxin", "pathway_ids": ["R-HSA-209968", "R-MMU-209968"], "pathways": ["R-HSA-209968:r:Thyroxine biosynthesis", "R-MMU-209968:r:Thyroxine biosynthesis"], "type": "Domain"}, "IPR058778": {"description": "FAR1-related sequence 11-like, HTH-like domain", "go_ids": [], "go_terms": [], "name": "HTH_FAR1-11-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058779": {"description": "NUP210, Ig-like domain 13", "go_ids": [], "go_terms": [], "name": "Ig_NUP210_13th", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-HSA-9705671", "R-HSA-3108214", "R-HSA-191859", "R-MMU-3232142", "R-RNO-3301854", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230", "R-MMU-4085377", "R-MMU-4551638", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-DME-4615885", "R-HSA-4570464", "R-RNO-159236", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-DME-4551638", "R-MMU-3301854", "R-DME-159227", "R-HSA-4085377", "R-HSA-168325", "R-MMU-170822", "R-RNO-159227", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-DME-159230", "R-RNO-4551638", "R-HSA-3232142", "R-HSA-3301854", "R-DME-3301854", "R-RNO-4085377", "R-MMU-159227", "R-RNO-170822", "R-RNO-4570464", "R-RNO-159231", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-RNO-191859:r:snRNP Assembly", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-DME-4615885:r:SUMOylation of DNA 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NTRK3 (TRKC)"], "type": "Domain"}, "IPR058860": {"description": "Mycoplasma immunoglobulin binding protein, M2 domain", "go_ids": [], "go_terms": [], "name": "MIB_M2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058861": {"description": "Mycoplasma immunoglobulin binding protein, arm domain", "go_ids": [], "go_terms": [], "name": "MIB_arm", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058862": {"description": "YgzA", "go_ids": [], "go_terms": [], "name": "YgzA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058863": {"description": "Pectate disaccharide-lyase-like, central Ig-like domain", "go_ids": [], "go_terms": [], "name": "PelX-like_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058864": {"description": "UBA-like domain, fungi", "go_ids": [], "go_terms": [], "name": "UBA_10", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058865": {"description": "GDPGP1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GDPGP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058866": {"description": "GDPGP1-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GDPGP1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058867": {"description": "YtzJ", "go_ids": [], "go_terms": [], "name": "YtzJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058868": {"description": "ARM repeat, N-terminal, plant", "go_ids": [], "go_terms": [], "name": "ARM_7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058869": {"description": "YqzN/YkzM", "go_ids": [], "go_terms": [], "name": "YqzN_YkzM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058870": {"description": "YuzC", "go_ids": [], "go_terms": [], "name": "YuzC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058871": {"description": "Zuotin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Zuotin_N", "pathway_ids": ["R-SCE-3371453", "R-SPO-3371453"], "pathways": ["R-SCE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR058872": {"description": "Profilin fold domain, halobacteria", "go_ids": [], "go_terms": [], "name": "Halo_prof", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058873": {"description": "GAPS4, PD-(D/E)XK nuclease domain", "go_ids": [], "go_terms": [], "name": "PDDEXK_GAPS4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058874": {"description": "Plant disease resistance, WDH", "go_ids": [], "go_terms": [], "name": "WHD_plant", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058875": {"description": "Minor capsid decoration protein", "go_ids": [], "go_terms": [], "name": "DEC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058876": {"description": "ZP-domain containing protein, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig-like_ZP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058877": {"description": "JAB/MPN domain-containing", "go_ids": [], "go_terms": [], "name": "JAB/MPN_dom-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058878": {"description": "PH domain-like, plasmodium", "go_ids": [], "go_terms": [], "name": "PH_plasmodium", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058879": {"description": "NTF2-like domain, nematodes 2", "go_ids": [], "go_terms": [], "name": "NTF2-like_dom_nem", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058880": {"description": "Alkaline phosphatase-like protein PglZ, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PglZ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058881": {"description": "Alkaline phosphatase-like protein PglZ, second domain", "go_ids": [], "go_terms": [], "name": "PglZ_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058882": {"description": "Alkaline phosphatase-like protein PglZ, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PglZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058883": {"description": "Cilium assembly protein DZIP1 domain", "go_ids": [], "go_terms": [], "name": "DZIP1_dom", "pathway_ids": ["R-DME-5632684", "R-HSA-5632684", "R-MMU-5632684", "R-DRE-5632684"], "pathways": ["R-DME-5632684:r:Hedgehog 'on' state", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-5632684:r:Hedgehog 'on' state", "R-DRE-5632684:r:Hedgehog 'on' state"], "type": "Domain"}, "IPR058884": {"description": "Cystin-1", "go_ids": [], "go_terms": [], "name": "Cys1", "pathway_ids": ["R-HSA-5624138"], "pathways": ["R-HSA-5624138:r:Trafficking of myristoylated proteins to the cilium"], "type": "Family"}, "IPR058885": {"description": "Winged helix domain, halobacteria", "go_ids": [], "go_terms": [], "name": "WHD_halobact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058886": {"description": "eIF2D, SWIB domain", "go_ids": [], "go_terms": [], "name": "SWIB_eIF2D", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058887": {"description": "Membrane protein YuzI", "go_ids": [], "go_terms": [], "name": "YuzI-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058888": {"description": "GPI-anchored protein LLG1-like domain", "go_ids": [], "go_terms": [], "name": "LLG1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058889": {"description": "SOWAHA-C, winged helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "WHD_SOWAHA-C", "pathway_ids": ["R-HSA-9013026", "R-MMU-9035034", "R-HSA-8980692", "R-HSA-9035034", "R-MMU-9013026", "R-MMU-8980692"], "pathways": ["R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Domain"}, "IPR058890": {"description": "Extrachromosomal elements maintenance protein EdmS", "go_ids": [], "go_terms": [], "name": "EdmS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058891": {"description": "Cryptic plasmid protein A", "go_ids": [], "go_terms": [], "name": "CPPA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058892": {"description": "ATP phosphoribosyltransferase-like", "go_ids": [], "go_terms": [], "name": "HisG-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058893": {"description": "Ribbon-helix-helix protein", "go_ids": [], "go_terms": [], "name": "RHH-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058894": {"description": "Phage phiTE_211, coil containing protein-like", "go_ids": [], "go_terms": [], "name": "PhiTE_211_coil-containing-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058895": {"description": "YkoA-like", "go_ids": [], "go_terms": [], "name": "YkoA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058896": {"description": "E3 ubiquitin-protein ligase RNF6/12, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RNF6/12_N", "pathway_ids": ["PWY-7511", "R-HSA-983168", "R-MMU-983168"], "pathways": ["PWY-7511:t:protein ubiquitination", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR058897": {"description": "Pappalysin-1, SD scarf domain, C-terminal", "go_ids": [], "go_terms": [], "name": "PAPPA_SD_C", "pathway_ids": ["R-MMU-381426", "R-HSA-381426"], "pathways": ["R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "type": "Domain"}, "IPR058898": {"description": "AP-3 complex subunit delta, Mu C-terminal domain", "go_ids": [], "go_terms": [], "name": "Mu_AP3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058899": {"description": "TGFBR3/Endoglin-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TGFBR3/Endoglin-like_N", "pathway_ids": ["R-MMU-9839406", "R-MMU-9839383", "R-HSA-9839406", "R-RNO-9839397", "R-MMU-2173789", "R-MMU-9839389", "R-HSA-9839394", "R-MMU-9839397", "R-HSA-201451", "R-RNO-9839383", "R-HSA-190373", "R-HSA-9839383", "R-HSA-1502540", "R-HSA-190370", "R-RNO-190370", "R-HSA-9839397", "R-HSA-9839389", "R-RNO-190373", "R-MMU-190370", "R-MMU-190373", "R-MMU-201451", "R-RNO-1502540", "R-RNO-201451", "R-RNO-9839389", "R-RNO-2173789", "R-RNO-9839406", "R-HSA-2173789", "R-MMU-1502540"], "pathways": ["R-MMU-9839406:r:TGFBR3 regulates activin signaling", "R-MMU-9839383:r:TGFBR3 PTM regulation", "R-HSA-9839406:r:TGFBR3 regulates activin signaling", "R-RNO-9839397:r:TGFBR3 regulates FGF2 signaling", "R-MMU-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-HSA-9839394:r:TGFBR3 expression", "R-MMU-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-201451:r:Signaling by BMP", "R-RNO-9839383:r:TGFBR3 PTM regulation", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-HSA-9839383:r:TGFBR3 PTM regulation", "R-HSA-1502540:r:Signaling by Activin", "R-HSA-190370:r:FGFR1b ligand binding and activation", "R-RNO-190370:r:FGFR1b ligand binding and activation", "R-HSA-9839397:r:TGFBR3 regulates FGF2 signaling", "R-HSA-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-190373:r:FGFR1c ligand binding and activation", "R-MMU-190370:r:FGFR1b ligand binding and activation", "R-MMU-190373:r:FGFR1c ligand binding and activation", "R-MMU-201451:r:Signaling by BMP", "R-RNO-1502540:r:Signaling by Activin", "R-RNO-201451:r:Signaling by BMP", "R-RNO-9839389:r:TGFBR3 regulates TGF-beta signaling", "R-RNO-2173789:r:TGF-beta receptor signaling activates SMADs", "R-RNO-9839406:r:TGFBR3 regulates activin signaling", "R-HSA-2173789:r:TGF-beta receptor signaling activates SMADs", "R-MMU-1502540:r:Signaling by Activin"], "type": "Domain"}, "IPR058900": {"description": "TTC28, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TTC28_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058901": {"description": "ATRX, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ATRX_C", "pathway_ids": ["PWY-7250", "R-HSA-9670613", "R-MMU-9670095", "R-HSA-9670615", "R-HSA-9670095"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-HSA-9670613:r:Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations", "R-MMU-9670095:r:Inhibition of DNA recombination at telomere", "R-HSA-9670615:r:Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "R-HSA-9670095:r:Inhibition of DNA recombination at telomere"], "type": "Domain"}, "IPR058902": {"description": "Zinc finger protein 292/Rlf, C2H2-type zinc finger", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_ZNF292/Rlf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058903": {"description": "YLPM1-like, spectrin repeat", "go_ids": [], "go_terms": [], "name": "Spectrin_YLPM1-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058904": {"description": "PARP4, MVP-ID C-terminal domain", "go_ids": [], "go_terms": [], "name": "PARP4_MVP-ID", "pathway_ids": ["R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein"], "type": "Domain"}, "IPR058905": {"description": "PARP4, WGR-like domain", "go_ids": [], "go_terms": [], "name": "WGR-like_PARP4", "pathway_ids": ["R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein"], "type": "Domain"}, "IPR058906": {"description": "Apoptosis-resistant E3 ubiquitin protein ligase 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AREL1_N", "pathway_ids": ["R-HSA-983168", "R-MMU-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR058907": {"description": "Broad-specificity ulvan lyase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "P29_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058908": {"description": "Broad-specificity ulvan lyase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "P29_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058909": {"description": "cGAS/DncV-like nucleotidyltransferase, C-terminal helical domain", "go_ids": [], "go_terms": [], "name": "CD_NTase_C", "pathway_ids": ["PWY-7735", "PWY-6626", "PWY-7529", "PWY-7419", "PWY-7888", "PWY-6322", "PWY-7769", "PWY-7719", "PWY-7904", "PWY-6749", "PWY-8179", "PWY-6998", "PWY-7127", "PWY-7737", "PWY-6955", "PWY-8117", "PWY-7706"], "pathways": ["PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-7529:t:CMP-N-acetyl-7-O-acetylneuraminate biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-7888:t:tRNA-uridine 2-thiolation (cytoplasmic)", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-7904:t:tRNA-uridine 2-thiolation (thermophilic bacteria)", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-8179:t:platensimycin biosynthesis", "PWY-6998:t:CDP-D-arabitol biosynthesis", "PWY-7127:t:CDP-D-mannitol biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-8117:t:colibactin biosynthesis", "PWY-7706:t:dapdiamides biosynthesis"], "type": "Domain"}, "IPR058910": {"description": "Protein of unknown function DUF8186, central domain", "go_ids": [], "go_terms": [], "name": "DUF8186_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058911": {"description": "Protein of unknown function DUF8186, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF8186_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058912": {"description": "Helix-turn-helix domain, animal", "go_ids": [], "go_terms": [], "name": "HTH_animal", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058913": {"description": "Integrase core domain, putative", "go_ids": [], "go_terms": [], "name": "Integrase_dom_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058914": {"description": "Liprin-beta-1/2, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "LIPB1/2_CC", "pathway_ids": ["R-HSA-388844", "R-HSA-9725370", "R-MMU-388844", "R-CEL-388844"], "pathways": ["R-HSA-388844:r:Receptor-type tyrosine-protein phosphatases", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-MMU-388844:r:Receptor-type tyrosine-protein phosphatases", "R-CEL-388844:r:Receptor-type tyrosine-protein phosphatases"], "type": "Domain"}, "IPR058915": {"description": "Anti-CRISPR type V subtype A2-like", "go_ids": [], "go_terms": [], "name": "AcrVA2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058916": {"description": "PH domain 40", "go_ids": [], "go_terms": [], "name": "PH_40", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058917": {"description": "RNA-editing substrate-binding complex 6 protein domain", "go_ids": [], "go_terms": [], "name": "RESC6_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058918": {"description": "Kalirin/TRIO-like, spectrin repeats", "go_ids": [], "go_terms": [], "name": "KALRN/TRIO-like_spectrin", "pathway_ids": ["R-MMU-416476", "R-HSA-9013409", "R-RNO-9013409", "R-MMU-8980692", "R-RNO-8980692", "R-MMU-9013408", "R-RNO-9013149", "R-RNO-5687128", "R-MMU-9013409", "R-HSA-416476", "R-HSA-418885", "R-MMU-9013148", "R-MMU-9013404", "R-DRE-9013404", "R-HSA-3928662", "R-HSA-9013423", "R-DRE-9013423", "R-RNO-416482", "R-HSA-9013148", "R-RNO-3928662", "R-DRE-9013149", "R-RNO-9013408", "R-RNO-9013404", "R-HSA-9013408", "R-RNO-416476", "R-RNO-193648", "R-HSA-193648", "R-DRE-9013408", "R-DRE-9013409", "R-DRE-416482", "R-HSA-416482", "R-RNO-9013148", "R-RNO-418885", "R-RNO-9013423", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-HSA-8980692", "R-HSA-5687128", "R-MMU-416482", "R-MMU-3928662", "R-MMU-193648", "R-DRE-8980692", "R-DRE-416476", "R-MMU-5687128", "R-DRE-193648", "R-MMU-9013149", "R-MMU-418885"], "pathways": ["R-MMU-416476:r:G alpha (q) signalling events", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-RNO-9013409:r:RHOJ GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-HSA-416476:r:G alpha (q) signalling events", "R-HSA-418885:r:DCC mediated attractive signaling", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DRE-9013404:r:RAC2 GTPase cycle", "R-HSA-3928662:r:EPHB-mediated forward signaling", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-DRE-9013423:r:RAC3 GTPase cycle", "R-RNO-416482:r:G alpha (12/13) signalling events", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-RNO-3928662:r:EPHB-mediated forward signaling", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-RNO-9013408:r:RHOG GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-RNO-416476:r:G alpha (q) signalling events", "R-RNO-193648:r:NRAGE signals death through JNK", "R-HSA-193648:r:NRAGE signals death through JNK", "R-DRE-9013408:r:RHOG GTPase cycle", "R-DRE-9013409:r:RHOJ GTPase cycle", "R-DRE-416482:r:G alpha (12/13) signalling events", "R-HSA-416482:r:G alpha (12/13) signalling events", "R-RNO-9013148:r:CDC42 GTPase cycle", "R-RNO-418885:r:DCC mediated attractive signaling", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-5687128:r:MAPK6/MAPK4 signaling", "R-MMU-416482:r:G alpha (12/13) signalling events", "R-MMU-3928662:r:EPHB-mediated forward signaling", "R-MMU-193648:r:NRAGE signals death through JNK", "R-DRE-8980692:r:RHOA GTPase cycle", "R-DRE-416476:r:G alpha (q) signalling events", "R-MMU-5687128:r:MAPK6/MAPK4 signaling", "R-DRE-193648:r:NRAGE signals death through JNK", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-MMU-418885:r:DCC mediated attractive signaling"], "type": "Domain"}, "IPR058919": {"description": "Pep3/Vps18, RING C-terminal domain", "go_ids": [], "go_terms": [], "name": "Pep3/Vps18_RING_C", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR058920": {"description": "PAP/OAS1 substrate-binding-related domain", "go_ids": [], "go_terms": [], "name": "PAP-OAS1-bd-rel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058921": {"description": "PAP/OAS1-related", "go_ids": [], "go_terms": [], "name": "PAP/OAS1-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058922": {"description": "Disease resistance protein, winged helix domain", "go_ids": [], "go_terms": [], "name": "WHD_DRP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058923": {"description": "RCC1-like domain", "go_ids": [], "go_terms": [], "name": "RCC1-like_dom", "pathway_ids": ["R-SCE-9615933", "R-DME-983168", "R-HSA-2467813", "R-HSA-3108214", "R-HSA-168928", "R-HSA-9833482", "R-MMU-2980767", "R-MMU-2467813", "R-SPO-9615933", "R-HSA-936440", "R-HSA-5693565", "R-DRE-2467813", "R-DRE-141444", "R-MMU-68877", "R-HSA-1169408", "R-CEL-983168", "R-HSA-9909505", "R-MMU-9615933", "R-MMU-5693565", "R-MMU-69473", "R-HSA-6793080", "R-CEL-9909505", "R-HSA-5693607", "R-CEL-936440", "R-HSA-68877", "R-HSA-165054", "R-HSA-2980767", "R-HSA-9833110", "R-DRE-5663220", "R-MMU-9648025", "R-MMU-5693607", "R-HSA-9937008", "R-MMU-2500257", "R-MMU-141444", "R-HSA-2500257", "R-HSA-69473", "R-DRE-2500257", "R-HSA-141444", "R-CEL-9833482", "R-HSA-983168", "R-HSA-9648025", "R-CEL-9615933", "R-DME-9615933", "R-HSA-3301854", "R-HSA-5693571", "R-HSA-9615933", "R-CEL-1169408", "R-MMU-983168", "R-HSA-5663220", "R-MMU-3108214", "R-HSA-180746", "R-RNO-983168", "R-MMU-5693571", "R-MMU-5663220"], "pathways": ["R-SCE-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-168928:r:DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-9833482:r:PKR-mediated signaling", "R-MMU-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-DRE-2467813:r:Separation of Sister Chromatids", "R-DRE-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-6793080:r:rRNA modification in the mitochondrion", "R-CEL-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-CEL-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-2980767:r:Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-9833110:r:RSV-host interactions", "R-DRE-5663220:r:RHO GTPases Activate Formins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-HSA-9937008:r:Mitochondrial mRNA modification", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-DRE-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-CEL-9833482:r:PKR-mediated signaling", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-CEL-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-CEL-1169408:r:ISG15 antiviral mechanism", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR058924": {"description": "N-acetyl-gamma-glutamyl-phosphate reductase, dimerisation domain", "go_ids": [], "go_terms": [], "name": "AGPR_dimerisation_dom", "pathway_ids": ["PWY-5154", "R-DDI-70635", "R-SCE-70635", "R-SPO-70635"], "pathways": ["PWY-5154:t:L-arginine biosynthesis III (via N-acetyl-L-citrulline)", "R-DDI-70635:r:Urea cycle", "R-SCE-70635:r:Urea cycle", "R-SPO-70635:r:Urea cycle"], "type": "Domain"}, "IPR058925": {"description": "Oxidoreductase AcuF-like, C2H2 type zinc-finger", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_AcuF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058926": {"description": "YmzB-like", "go_ids": [], "go_terms": [], "name": "YmzB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058927": {"description": "Membrane associated OB-fold-like protein", "go_ids": [], "go_terms": [], "name": "OB_2TM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058928": {"description": "Type VII secretion system extracellular protein C", "go_ids": [], "go_terms": [], "name": "EsxC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058929": {"description": "Ig-like domain, halobacteria", "go_ids": [], "go_terms": [], "name": "Ig_halo", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058930": {"description": "YwzD", "go_ids": [], "go_terms": [], "name": "YwzD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058931": {"description": "SnoaL-like domain 6", "go_ids": [], "go_terms": [], "name": "SnoaL_6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058932": {"description": "L-erythro-3,5-diaminohexanoate dehydrogenase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "KDD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058933": {"description": "YMC020W-like, alpha/beta hydrolase domain", "go_ids": [], "go_terms": [], "name": "YMC020W-like_ab_hydrolase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058934": {"description": "YMC020W-like", "go_ids": [], "go_terms": [], "name": "YMC020W-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058935": {"description": "At4g15545-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "At4g15545-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058936": {"description": "At4g15545-like", "go_ids": ["GO:0080119"], "go_terms": ["GO:0080119:ER body organization:P"], "name": "At4g15545-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058937": {"description": "Hsps-like, putative, alpha-crystallin-like domain", "go_ids": [], "go_terms": [], "name": "ACL_Hsps-like_put", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058938": {"description": "Ribonuclease 3, central domain, two antiparallel helical region", "go_ids": [], "go_terms": [], "name": "Helical_CED_Drosha", "pathway_ids": ["R-HSA-203927"], "pathways": ["R-HSA-203927:r:MicroRNA (miRNA) biogenesis"], "type": "Domain"}, "IPR058939": {"description": "EDM2, methyltransferase-like domain", "go_ids": [], "go_terms": [], "name": "Mtase_EDM2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058940": {"description": "Small ribosomal subunit protein mS26, fungi", "go_ids": ["GO:0003735"], "go_terms": ["GO:0003735:structural constituent of ribosome:F"], "name": "mS26_fungi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058941": {"description": "AT3G52170-like, helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "HTH_AT3G52170-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058942": {"description": "AT3G52170-like", "go_ids": [], "go_terms": [], "name": "AT3G52170-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058943": {"description": "GT-1/4-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GT-1/4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058944": {"description": "Histidine racemase", "go_ids": [], "go_terms": [], "name": "CntK-like", "pathway_ids": ["PWY-8007"], "pathways": ["PWY-8007:t:staphylopine biosynthesis"], "type": "Family"}, "IPR058945": {"description": "Histidine racemase CntK", "go_ids": [], "go_terms": [], "name": "CntK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058946": {"description": "ZNF451, C-terminal C2H2 type zinc fingers", "go_ids": [], "go_terms": [], "name": "Zf-C2H2_ZNF451_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058947": {"description": "ZNF451, second C2H2 type zinc finger", "go_ids": [], "go_terms": [], "name": "Zf-C2H2_ZNF451_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058948": {"description": "ZNF451, sixth C2H2 type zinc finger", "go_ids": [], "go_terms": [], "name": "Zf-C2H2_ZNF451_6th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058949": {"description": "ZNF451, first C2H2 type zinc finger", "go_ids": [], "go_terms": [], "name": "Zf-C2H2_ZNF451_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058950": {"description": "ZNF451, fifth C2H2 type zinc finger", "go_ids": [], "go_terms": [], "name": "Zf-C2H2_ZNF451_5th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058951": {"description": "Rad26/CSB-like, winged helix DNA-binding domain", "go_ids": [], "go_terms": [], "name": "WHD_Rad26_CSB-like", "pathway_ids": ["PWY-7250", "R-MMU-5250924", "R-MMU-73762", "R-MMU-6781823", "R-HSA-6781827", "R-MMU-6782135", "R-HSA-5250924", "R-SCE-6781823", "R-HSA-427389", "R-HSA-6782210", "R-MMU-6782210", "R-HSA-6782135", "R-HSA-73762", "R-SCE-6782210", "R-HSA-6781823", "R-SCE-6782135"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-73762:r:RNA Polymerase I Transcription Initiation", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-SCE-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-HSA-427389:r:ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6782135:r:Dual incision in TC-NER", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation", "R-SCE-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-HSA-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-SCE-6782135:r:Dual incision in TC-NER"], "type": "Domain"}, "IPR058952": {"description": "CFAP47-like, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig_CFAP47", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058953": {"description": "Pectate disaccharide-lyase-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PelX-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058954": {"description": "SMAX1-like, AAA+ ATPase lid domain", "go_ids": [], "go_terms": [], "name": "AAA_lid_SMAX1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058955": {"description": "GAPS4b, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GAPS4b_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058956": {"description": "Magnetosome protein MamC", "go_ids": [], "go_terms": [], "name": "MamC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058957": {"description": "Putative peptidase inhibitor domain", "go_ids": [], "go_terms": [], "name": "Peptidase_inhib_put_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058958": {"description": "CI111, double-psi beta-barrel domain", "go_ids": [], "go_terms": [], "name": "DPBB_CI111", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058959": {"description": "Protein of unknown function DUF8157, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF8157_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058960": {"description": "Ctg-1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ctg-1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058961": {"description": "YafT", "go_ids": [], "go_terms": [], "name": "YafT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058962": {"description": "DUF8108-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF8108_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058963": {"description": "Protein of unknown function DUF8108, central domain", "go_ids": [], "go_terms": [], "name": "DUF8108_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058964": {"description": "Cap2, central linker domain", "go_ids": [], "go_terms": [], "name": "Cap2_linker", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058965": {"description": "Styrene oxide isomerase/Hydroxylaminobenzene mutase-like", "go_ids": [], "go_terms": [], "name": "SOI/HabA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058966": {"description": "MJECL33-like", "go_ids": [], "go_terms": [], "name": "MJECL33-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058967": {"description": "Hfq-like protein", "go_ids": [], "go_terms": [], "name": "Hfq-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058968": {"description": "SPbeta prophage-derived uncharacterized protein YoqH-like", "go_ids": [], "go_terms": [], "name": "YoqH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR058969": {"description": "Putative phage tail fibre, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Phage_phiTE_241_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR058970": {"description": "Putative phage tail fibre, C-terminal domain", 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"go_ids": [], "go_terms": [], "name": "Mso1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059109": {"description": "Apolipoprotein N-acyltransferase, integral membrane domain, campylobacterales", "go_ids": [], "go_terms": [], "name": "Lnt_membrane_dom", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Domain"}, "IPR059110": {"description": "Apolipoprotein N-acyltransferase, campylobacterales", "go_ids": [], "go_terms": [], "name": "Lnt_campylobact", "pathway_ids": ["PWY-7884"], "pathways": ["PWY-7884:t:lipoprotein posttranslational modification (Gram-negative bacteria)"], "type": "Family"}, "IPR059111": {"description": "Trm72, C-terminal ARM-like repeat", "go_ids": [], "go_terms": [], "name": "Trm732_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059112": {"description": "Sulfate transporter CysZ/Etoposide-induced protein 2.4", "go_ids": [], "go_terms": [], "name": "CysZ/EI24", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059113": {"description": "Putative zinc-ribbon domain 3", "go_ids": [], "go_terms": [], "name": "Znf_ribbon_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059114": {"description": "NUDT9-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NUDT9_N", "pathway_ids": ["R-HSA-6798695", "R-CEL-2393930", "R-MMU-2393930", "R-RNO-3295583", "R-RNO-2393930", "R-CEL-3295583", "R-MMU-3295583", "R-HSA-2393930", "R-MMU-6798695", "R-RNO-6798695", "R-HSA-3295583"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-CEL-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-MMU-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-RNO-3295583:r:TRP channels", "R-RNO-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-CEL-3295583:r:TRP channels", "R-MMU-3295583:r:TRP channels", "R-HSA-2393930:r:Phosphate bond hydrolysis by NUDT proteins", "R-MMU-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-3295583:r:TRP channels"], "type": "Domain"}, "IPR059115": {"description": "Rib domain", "go_ids": [], "go_terms": [], "name": "Rib", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059116": {"description": "ATP P2X receptor-like", "go_ids": [], "go_terms": [], "name": "P2X_receptor", "pathway_ids": ["R-HSA-6798695", "R-DDI-6798695", "R-HSA-139853", "R-MMU-139853", "R-MMU-418346", "R-DDI-139853", "R-DDI-418346", "R-HSA-9660826", "R-BTA-418346", "R-HSA-9856532", "R-DDI-844456", "R-RNO-844456", "R-MMU-844456", "R-RNO-418346", "R-DRE-418346", "R-BTA-139853", "R-RNO-139853", "R-MMU-6798695", "R-DRE-139853", "R-HSA-418346", "R-RNO-6798695", "R-HSA-844456"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-418346:r:Platelet homeostasis", "R-DDI-139853:r:Elevation of cytosolic Ca2+ levels", "R-DDI-418346:r:Platelet homeostasis", "R-HSA-9660826:r:Purinergic signaling in leishmaniasis infection", "R-BTA-418346:r:Platelet homeostasis", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-DDI-844456:r:The NLRP3 inflammasome", "R-RNO-844456:r:The NLRP3 inflammasome", "R-MMU-844456:r:The NLRP3 inflammasome", "R-RNO-418346:r:Platelet homeostasis", "R-DRE-418346:r:Platelet homeostasis", "R-BTA-139853:r:Elevation of cytosolic Ca2+ levels", "R-RNO-139853:r:Elevation of cytosolic Ca2+ levels", "R-MMU-6798695:r:Neutrophil degranulation", "R-DRE-139853:r:Elevation of cytosolic Ca2+ levels", "R-HSA-418346:r:Platelet homeostasis", "R-RNO-6798695:r:Neutrophil degranulation", "R-HSA-844456:r:The NLRP3 inflammasome"], "type": "Family"}, "IPR059117": {"description": "APS kinase domain", "go_ids": [], "go_terms": [], "name": "APS_kinase_dom", "pathway_ids": ["PWY-5340", "R-MMU-174362", "R-MTU-936635", "R-HSA-6802952", "R-SCE-174362", "R-HSA-174362", "R-SPO-174362", "R-HSA-2408550", "R-CEL-174362", "R-HSA-3560796"], "pathways": ["PWY-5340:t:sulfate activation for sulfonation", "R-MMU-174362:r:Transport and metabolism of PAPS", "R-MTU-936635:r:Sulfate assimilation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-SCE-174362:r:Transport and metabolism of PAPS", "R-HSA-174362:r:Transport and metabolism of PAPS", "R-SPO-174362:r:Transport and metabolism of PAPS", "R-HSA-2408550:r:Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "R-CEL-174362:r:Transport and metabolism of PAPS", "R-HSA-3560796:r:Defective PAPSS2 causes SEMD-PA"], "type": "Domain"}, "IPR059118": {"description": "PD-(D/E)XK nuclease-like domain, halobacteria", "go_ids": [], "go_terms": [], "name": "PDDEXK_dom_halobact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059119": {"description": "NTF2-like", "go_ids": [], "go_terms": [], "name": "NTF2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059120": {"description": "Cullin-like, alpha+beta domain", "go_ids": [], "go_terms": [], "name": "Cullin-like_AB", "pathway_ids": ["R-HSA-9020702", "R-HSA-174178", "R-HSA-9013418", "R-HSA-9604323", "R-RNO-9013422", "R-CEL-5632684", "R-HSA-8951664", "R-MMU-174154", "R-HSA-9010553", "R-MMU-69017", "R-CEL-195253", "R-MMU-9020702", "R-DDI-6782210", "R-MMU-9706019", "R-HSA-69231", "R-RNO-8863795", "R-DDI-179409", "R-MMU-110314", "R-CEL-110314", "R-HSA-5684264", "R-CEL-1234176", "R-HSA-8863795", "R-DDI-9929491", "R-SPO-917937", "R-XTR-9013418", "R-DME-5676590", "R-HSA-8854050", "R-MMU-5696394", "R-DDI-176407", "R-CEL-5696394", "R-HSA-5610783", "R-HSA-2122947", "R-CEL-69231", "R-MMU-174084", "R-HSA-9708530", "R-HSA-1234176", "R-RNO-4641258", "R-CEL-917937", "R-HSA-5607761", "R-HSA-9929491", "R-HSA-1170546", "R-DDI-174084", "R-MMU-68867", "R-MMU-176409", "R-MMU-174113", "R-DME-209461", "R-XTR-9929491", "R-MMU-2559582", "R-RNO-9705462", "R-CEL-6782210", "R-MMU-1234176", "R-MMU-4641258", "R-DDI-4641258", "R-DDI-5696394", "R-RNO-8951664", "R-SPO-110314", "R-HSA-5696395", "R-HSA-5696394", "R-CEL-5696395", "R-CEL-6782135", "R-DME-69601", "R-SPO-8951664", "R-HSA-2644606", "R-HSA-174048", "R-HSA-179409", "R-MMU-9013418", "R-DDI-9013418", "R-DDI-187577", "R-HSA-174154", "R-HSA-9833109", "R-SCE-917937", "R-RNO-5632684", "R-HSA-5610785", "R-HSA-68949", "R-DME-983168", "R-HSA-6781827", "R-DME-202424", "R-DME-187577", "R-DDI-5696395", "R-MMU-187577", "R-HSA-2467813", "R-SCE-8854050", "R-MMU-179409", "R-MMU-68949", "R-DME-2565942", "R-DDI-174178", "R-MMU-174178", "R-CEL-983168", "R-DDI-9013422", "R-CEL-8854050", "R-MMU-917937", "R-MMU-6781823", "R-DDI-9706019", "R-DDI-176409", "R-DDI-69601", "R-HSA-6782210", "R-DDI-2467813", "R-DDI-176412", "R-MMU-9762114", "R-HSA-9762114", "R-DME-917937", "R-MMU-195253", "R-MMU-5696400", "R-MMU-202424", "R-RNO-9013418", "R-HSA-195253", "R-HSA-176412", "R-HSA-5610780", "R-HSA-381038", "R-DME-209360", "R-MMU-176408", "R-CEL-9755511", "R-DDI-917937", "R-DDI-69231", "R-RNO-9755511", "R-MMU-1169091", "R-MMU-69231", "R-XTR-8951664", "R-MMU-176412", "R-MMU-5607761", "R-DME-8854050", "R-MMU-5676590", "R-HSA-8939902", "R-HSA-9725371", "R-MMU-174184", "R-DDI-174184", "R-MMU-8939902", "R-CEL-2565942", "R-SPO-6782210", "R-HSA-5696400", "R-DME-9020702", "R-CEL-9762114", "R-CEL-8951664", "R-SPO-8854050", "R-DDI-8854050", "R-MMU-5632684", "R-HSA-9013422", "R-MMU-5607764", "R-MMU-2467813", "R-DME-8951664", "R-HSA-9932298", "R-DME-69231", "R-CEL-187577", "R-HSA-5676590", "R-MMU-2565942", "R-DDI-8951664", "R-HSA-6781823", "R-DDI-5632684", "R-MMU-8951664", "R-MMU-5696395", "R-SPO-5696395", "R-DME-174113", "R-DME-8939902", "R-MMU-9013422", "R-HSA-141430", "R-DDI-2559582", "R-MMU-9929491", "R-HSA-174113", "R-MMU-9929356", "R-HSA-176408", "R-HSA-68867", "R-MMU-5684264", "R-HSA-176409", "R-DME-9762114", "R-CEL-4641258", "R-SPO-2559582", "R-HSA-9687136", "R-DDI-5658442", "R-DDI-6781823", "R-HSA-9755511", "R-XTR-4641258", "R-SPO-179409", "R-DDI-174048", "R-HSA-4641258", "R-CEL-9929491", "R-MMU-9705462", "R-MMU-9708530", "R-CEL-6781823", "R-HSA-180585", "R-HSA-1169091", "R-HSA-5658442", "R-HSA-2644607", "R-MMU-141430", "R-MMU-2871837", "R-DDI-141430", "R-DDI-68949", "R-DME-5610785", "R-MMU-6782210", "R-DME-5607764", "R-RNO-983168", "R-DME-2871837", "R-HSA-110314", "R-DDI-176408", "R-DDI-6782135", "R-MMU-8863795", "R-HSA-8853884", "R-MMU-5610780", "R-HSA-187577", "R-DME-1169091", "R-CEL-8863795", "R-XTR-5632684", "R-DDI-9755511", "R-MMU-6782135", "R-SPO-176408", "R-DME-5610780", "R-XTR-9013422", "R-CEL-8939902", "R-MMU-9755511", "R-HSA-2559582", "R-HSA-174184", "R-MMU-9954709", "R-DME-195253", "R-MMU-174048", "R-MMU-69601", "R-HSA-2565942", "R-HSA-2871837", "R-MMU-5610785", "R-HSA-9954709", "R-DME-5607761", "R-MMU-8854050", "R-SPO-983168", "R-MMU-5658442", "R-SCE-983168", "R-HSA-174084", "R-HSA-176407", "R-HSA-5607764", "R-DME-68949", "R-DDI-69017", "R-MMU-1170546", "R-CEL-9954709", "R-RNO-9929491", "R-HSA-9706019", "R-HSA-2894862", "R-RNO-9706019", "R-HSA-69601", "R-HSA-9679191", "R-HSA-983168", "R-HSA-6782135", "R-HSA-5632684", "R-MMU-176407", "R-DDI-983168", "R-HSA-9929356", "R-CEL-68949", "R-CEL-69601", "R-XTR-983168", "R-SPO-5696400", "R-XTR-9755511", "R-RNO-5658442", "R-HSA-917937", "R-HSA-9705462", "R-HSA-69017", "R-MMU-983168", "R-SPO-6782135", "R-HSA-202424", "R-DDI-174154"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-9604323:r:Negative regulation of NOTCH4 signaling", "R-RNO-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-5632684:r:Hedgehog 'on' state", "R-HSA-8951664:r:Neddylation", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-CEL-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-9020702:r:Interleukin-1 signaling", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-9706019:r:RHOBTB3 ATPase cycle", "R-HSA-69231:r:Cyclin D associated events in G1", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-CEL-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-CEL-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-DDI-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-SPO-917937:r:Iron uptake and transport", "R-XTR-9013418:r:RHOBTB2 GTPase cycle", "R-DME-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-5696394:r:DNA Damage Recognition in GG-NER", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-CEL-5696394:r:DNA Damage Recognition in GG-NER", "R-HSA-5610783:r:Degradation of GLI2 by the proteasome", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-CEL-69231:r:Cyclin D associated events in G1", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-9708530:r:Regulation of BACH1 activity", "R-HSA-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-RNO-4641258:r:Degradation of DVL", "R-CEL-917937:r:Iron uptake and transport", "R-HSA-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-1170546:r:Prolactin receptor signaling", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-MMU-174113:r:SCF-beta-TrCP mediated degradation of Emi1", "R-DME-209461:r:Ubiquitination and degradation of phosphorylated ARM", "R-XTR-9929491:r:SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-RNO-9705462:r:Inactivation of CSF3 (G-CSF) signaling", "R-CEL-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-1234176:r:Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-MMU-4641258:r:Degradation of DVL", "R-DDI-4641258:r:Degradation of DVL", "R-DDI-5696394:r:DNA Damage Recognition in GG-NER", "R-RNO-8951664:r:Neddylation", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5696395:r:Formation of Incision Complex in GG-NER", "R-HSA-5696394:r:DNA Damage Recognition in GG-NER", "R-CEL-5696395:r:Formation of Incision Complex in GG-NER", "R-CEL-6782135:r:Dual incision in TC-NER", "R-DME-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-SPO-8951664:r:Neddylation", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-9013418:r:RHOBTB2 GTPase cycle", "R-DDI-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-SCE-917937:r:Iron uptake and transport", "R-RNO-5632684:r:Hedgehog 'on' state", "R-HSA-5610785:r:GLI3 is processed to GLI3R by the proteasome", "R-HSA-68949:r:Orc1 removal from chromatin", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6781827:r:Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "R-DME-202424:r:Downstream TCR signaling", "R-DME-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-DDI-5696395:r:Formation of Incision Complex in GG-NER", "R-MMU-187577:r:SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-SCE-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-68949:r:Orc1 removal from chromatin", "R-DME-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-9013422:r:RHOBTB1 GTPase cycle", "R-CEL-8854050:r:FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-MMU-917937:r:Iron uptake and transport", "R-MMU-6781823:r:Formation of TC-NER Pre-Incision Complex", "R-DDI-9706019:r:RHOBTB3 ATPase cycle", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-69601:r:Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-MMU-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9762114:r:GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-DME-917937:r:Iron uptake and transport", "R-MMU-195253:r:Degradation of beta-catenin by the destruction complex", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-9013418:r:RHOBTB2 GTPase cycle", "R-HSA-195253:r:Degradation of beta-catenin by the destruction complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-HSA-5610780:r:Degradation of GLI1 by the proteasome", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-DME-209360:r:Ubiquitination 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cyclase-like sensor domain", "go_ids": [], "go_terms": [], "name": "Diguanyl_cycl_sensor_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059128": {"description": "Maltogenic amylase, second beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "SMMA_beta-sandwich_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059129": {"description": "Pathogenicity island 2 effector protein SseE, putative", "go_ids": [], "go_terms": [], "name": "SseE_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059130": {"description": "Morphogenic membrane protein MmpA, putative", "go_ids": [], "go_terms": [], "name": "MmpA_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059131": {"description": "Intron-associated endonuclease 1, zinc finger domain", "go_ids": [], "go_terms": [], "name": "I-TevI_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059132": {"description": "Quorum sensing histidine kinase QseC", "go_ids": [], "go_terms": [], "name": "QseC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059133": {"description": "TsoY-like", "go_ids": [], "go_terms": [], "name": "TsoY-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059134": {"description": "BsNagA, composite domain", "go_ids": [], "go_terms": [], "name": "BsNagA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059135": {"description": "APOBEC2, cytosine deaminase domain", "go_ids": [], "go_terms": [], "name": "APOBEC2_CD_dom", "pathway_ids": ["R-HSA-75094", "R-HSA-72200", "R-MMU-75094", "R-MMU-72200"], "pathways": ["R-HSA-75094:r:Formation of the Editosome", "R-HSA-72200:r:mRNA Editing: C to U Conversion", "R-MMU-75094:r:Formation of the Editosome", "R-MMU-72200:r:mRNA Editing: C to U Conversion"], "type": "Domain"}, "IPR059136": {"description": "APOBEC3, cytosine deaminase domain", "go_ids": [], "go_terms": [], "name": "APOBEC3_CD_dom", "pathway_ids": ["R-HSA-180585", "R-RNO-72200", "R-MMU-72200", "R-HSA-72200", "R-RNO-75094", "R-MMU-75094", "R-HSA-180689", "R-HSA-75094"], "pathways": ["R-HSA-180585:r:Vif-mediated degradation of APOBEC3G", "R-RNO-72200:r:mRNA Editing: C to U Conversion", "R-MMU-72200:r:mRNA Editing: C to U Conversion", "R-HSA-72200:r:mRNA Editing: C to U Conversion", "R-RNO-75094:r:Formation of the Editosome", "R-MMU-75094:r:Formation of the Editosome", "R-HSA-180689:r:APOBEC3G mediated resistance to HIV-1 infection", "R-HSA-75094:r:Formation of the Editosome"], "type": "Domain"}, "IPR059138": {"description": "Picornavirus capsid VP1", "go_ids": [], "go_terms": [], "name": "Pico_VP1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059141": {"description": "Nucleoporin Nup120/160, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_Nup120_160", "pathway_ids": ["R-SPO-3371453", "R-HSA-180910", "R-HSA-191859", "R-HSA-2467813", "R-SPO-159227", "R-HSA-3108214", "R-HSA-9705671", "R-SPO-159231", "R-MMU-3232142", "R-MMU-2467813", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-SPO-9615933", "R-DME-4085377", "R-MMU-68877", "R-HSA-1169408", "R-HSA-170822", "R-MMU-4615885", "R-MMU-9615933", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-MMU-4085377", "R-MMU-4551638", "R-HSA-3371453", "R-HSA-68877", "R-HSA-165054", "R-HSA-4570464", "R-DME-4615885", "R-SPO-4085377", "R-HSA-4615885", "R-MMU-9648025", "R-HSA-4551638", "R-MMU-191859", "R-DME-3108214", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-MMU-2500257", "R-HSA-2500257", "R-DME-3371453", "R-SPO-159236", "R-HSA-168276", "R-HSA-168271", "R-MMU-141444", "R-SPO-4551638", "R-HSA-6784531", "R-DME-4551638", "R-HSA-141444", "R-HSA-4085377", "R-HSA-168325", "R-MMU-3301854", "R-HSA-9648025", "R-DME-159227", "R-HSA-9609690", "R-MMU-170822", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-DME-159230", "R-DME-9615933", "R-HSA-9615933", "R-MMU-159227", "R-SPO-4570464", "R-DME-3301854", "R-HSA-5619107", "R-HSA-5663220", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-MMU-5663220"], "pathways": ["R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-HSA-191859:r:snRNP Assembly", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-SPO-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-68877:r:Mitotic Prometaphase", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-68877:r:Mitotic Prometaphase", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-MMU-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-141444:r:Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9648025:r:EML4 and NUDC in mitotic spindle formation", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-DME-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-5663220:r:RHO GTPases Activate Formins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-MMU-5663220:r:RHO GTPases Activate Formins"], "type": "Domain"}, "IPR059142": {"description": "Uncharacterized protein YGL204C", "go_ids": [], "go_terms": [], "name": "YGL204C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059143": {"description": "NFP, second LysM domain", "go_ids": [], "go_terms": [], "name": "NFP_LysM2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059144": {"description": "NFP, third LysM domain", "go_ids": [], "go_terms": [], "name": "NFP_LysM3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059145": {"description": "Maltogenic amylase, GHD-like C-terminal domain", "go_ids": [], "go_terms": [], "name": "SMMA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059146": {"description": "Ctf19, first RWD domain", "go_ids": [], "go_terms": [], "name": "Ctf19_RWD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059147": {"description": "Ctf19, second RWD domain", "go_ids": [], "go_terms": [], "name": "Ctf19_RWD2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059148": {"description": "Crb2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Crb2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059149": {"description": "Protein EFFECTOR OF TRANSCRIPTION 2/3, GIY-YIG domain", "go_ids": [], "go_terms": [], "name": "GIY_YIG_dom_ET2/3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059150": {"description": "Pichia pastoris 6-phosphofructokinase, gamma subunit, C-terminal", "go_ids": [], "go_terms": [], "name": "PpPfk_gamma_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059151": {"description": "RavZ, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RavZ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059152": {"description": "VWC2L-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "VWC2L_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059153": {"description": "Histone-lysine N-methyltransferase NSD-like, PHD zinc finger 1", "go_ids": [], "go_terms": [], "name": "NSD_PHD-1st", "pathway_ids": ["R-MMU-69473", "R-HSA-5693571", "R-HSA-5693607", "R-MMU-3214841", "R-HSA-3214841", "R-HSA-69473", "R-HSA-5693565", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-5693565"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-MMU-3214841:r:PKMTs methylate histone lysines", "R-HSA-3214841:r:PKMTs methylate histone lysines", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-HSA-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-MMU-5693571:r:Nonhomologous End-Joining (NHEJ)", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-MMU-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "type": "Domain"}, "IPR059154": {"description": "D-glucuronyl C5-epimerase, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Glce_b_sandwich", "pathway_ids": ["PWY-6558", "R-HSA-2022928"], "pathways": ["PWY-6558:t:heparan sulfate biosynthesis", "R-HSA-2022928:r:HS-GAG biosynthesis"], "type": "Domain"}, "IPR059155": {"description": "Glyoxalase domain-containing protein 4 domain", "go_ids": [], "go_terms": [], "name": "GLOD4_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059156": {"description": "WDR36/Utp21, second beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_WDR36-Utp21_2nd", "pathway_ids": ["R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR059157": {"description": "WDR36/Utp21, N-terminal domain", "go_ids": [], "go_terms": [], "name": "WDR36-Utp21_N", "pathway_ids": ["R-SCE-6791226", "R-SPO-6791226", "R-HSA-6791226", "R-HSA-6790901"], "pathways": ["R-SCE-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-SPO-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6791226:r:Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-6790901:r:rRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR059161": {"description": "STOP2/WIP2-like, C2H2-type zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_STOP1/2_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059164": {"description": "PRP39, C-terminal HAT repeat", "go_ids": [], "go_terms": [], "name": "HAT_PRP39_C", "pathway_ids": ["R-DRE-72163", "R-DME-72163"], "pathways": ["R-DRE-72163:r:mRNA Splicing - Major Pathway", "R-DME-72163:r:mRNA Splicing - Major Pathway"], "type": "Repeat"}, "IPR059173": {"description": "Conjugative transfer protein TraA-like", "go_ids": [], "go_terms": [], "name": "TraA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059176": {"description": "UDP-X diphosphatase-like, N-terminal oligomerisation domain", "go_ids": [], "go_terms": [], "name": "UDP-X_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059177": {"description": "GH29D-like, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "GH29D-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059203": {"description": "APOBEC4, cytosine deaminase domain", "go_ids": [], "go_terms": [], "name": "APOBEC4_CD_dom", "pathway_ids": ["PWY-7081", "R-RNO-72200", "R-RNO-75094", "R-HSA-72200", "R-MMU-75094", "R-MMU-72200", "R-HSA-75094"], "pathways": ["PWY-7081:t:4-aminophenol degradation", "R-RNO-72200:r:mRNA Editing: C to U Conversion", "R-RNO-75094:r:Formation of the Editosome", "R-HSA-72200:r:mRNA Editing: C to U Conversion", "R-MMU-75094:r:Formation of the Editosome", "R-MMU-72200:r:mRNA Editing: C to U Conversion", "R-HSA-75094:r:Formation of the Editosome"], "type": "Domain"}, "IPR059205": {"description": "Invertebrate-AID/APOBEC-deaminase", "go_ids": [], "go_terms": [], "name": "Inv-AAD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059206": {"description": "P-loop ATPase, Sll1717-like", "go_ids": [], "go_terms": [], "name": "Sll1717-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059207": {"description": "Fatty acid synthase, SBS domain", "go_ids": [], "go_terms": [], "name": "SBS_FAS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059208": {"description": "F0F1 ATP synthase subunit alpha, putative", "go_ids": [], "go_terms": [], "name": "ATP_synth_asu_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059209": {"description": "YdhT-like", "go_ids": [], "go_terms": [], "name": "YdhT-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059210": {"description": "Methylation-associated defense system protein MAD4-like", "go_ids": [], "go_terms": [], "name": "MADS4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059211": {"description": "BOW99_gp33-like", "go_ids": [], "go_terms": [], "name": "BOW99_gp33-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059212": {"description": "TIMELESS, tri-helical helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "HTH_TIMELESS", "pathway_ids": ["R-DME-432620", "R-DME-538898", "R-HSA-5693607", "R-DME-432553", "R-DME-432395", "R-RNO-5693607", "R-DME-432490", "R-DME-432501", "R-MMU-5693607"], "pathways": ["R-DME-432620:r:Dephosphorylation of PER", "R-DME-538898:r:Dephosphorylation of TIM", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-432395:r:Degradation of TIM", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DME-432490:r:Nuclear import of PER and TIM", "R-DME-432501:r:Transcription repression by PER and activation by PDP1", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Domain"}, "IPR059213": {"description": "Killing protein KilR", "go_ids": [], "go_terms": [], "name": "KilR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059214": {"description": "MSC_0882-like", "go_ids": [], "go_terms": [], "name": "MSC_0882-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059216": {"description": "2-isopropylmalate synthase, N-terminal carph-isopro domain", "go_ids": [], "go_terms": [], "name": "LeuA_carph_isopro_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059217": {"description": "LA_3751/LA_3752-like, putative", "go_ids": [], "go_terms": [], "name": "LA3751_2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059218": {"description": "LBP_cg2779-like", "go_ids": [], "go_terms": [], "name": "LBP_cg2779-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059219": {"description": "Peroxin 8, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Pex8_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR059220": {"description": "AbiEi antitoxin", "go_ids": [], "go_terms": [], "name": "AbiEi", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059221": {"description": "Hypothetical fimbrial protein", "go_ids": [], "go_terms": [], "name": "Hypothethical_fimbrial", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059222": {"description": "NGO0469-like", "go_ids": [], "go_terms": [], "name": "NGO0469-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059223": {"description": "DVU0772-like", "go_ids": [], "go_terms": [], "name": "DVU0772-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059224": {"description": "SLATT domain-containing", "go_ids": [], "go_terms": [], "name": "SLATT_dom-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059225": {"description": "BspC", "go_ids": [], "go_terms": [], "name": "BspC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR059226": {"description": "Choice-of-anchor Q 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"R-MMU-209968", "R-SSC-209968", "R-RNO-209968", "R-CFA-209968", "R-HSA-209968", "R-DME-209968", "R-CEL-209968"], "pathways": ["PWY-5292:t:vindoline, vindorosine and vinblastine biosynthesis", "R-MMU-209968:r:Thyroxine biosynthesis", "R-SSC-209968:r:Thyroxine biosynthesis", "R-RNO-209968:r:Thyroxine biosynthesis", "R-CFA-209968:r:Thyroxine biosynthesis", "R-HSA-209968:r:Thyroxine biosynthesis", "R-DME-209968:r:Thyroxine biosynthesis", "R-CEL-209968:r:Thyroxine biosynthesis"], "type": "Domain"}, "IPR060054": {"description": "Y4kK, central domain", "go_ids": [], "go_terms": [], "name": "Y4kK_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060055": {"description": "Phospholipase D C, PH domain-like", "go_ids": [], "go_terms": [], "name": "PldC_PH", "pathway_ids": ["R-DDI-2029485", "R-DDI-9013149", "R-DDI-1483166", "R-DDI-9013404"], "pathways": ["R-DDI-2029485:r:Role of phospholipids in phagocytosis", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-DDI-1483166:r:Synthesis of PA", "R-DDI-9013404:r:RAC2 GTPase cycle"], "type": "Domain"}, "IPR060056": {"description": "DUF1631, C-terminal tudor domain", "go_ids": [], "go_terms": [], "name": "DUF1631_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060057": {"description": "Epidermal growth factor-like protein, EGF domain", "go_ids": [], "go_terms": [], "name": "EGF_EGF-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060058": {"description": "Prophage endopeptidase tail domain", "go_ids": [], "go_terms": [], "name": "Prophage_tail_N2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060059": {"description": "Probable ATP-binding protein BrxC, seventh domain", "go_ids": [], "go_terms": [], "name": "BREX_BrxC_7th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060060": {"description": "AF_0155, Rossmann-like domain", "go_ids": [], "go_terms": [], "name": "Rossmann-like_AF_0155", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060061": {"description": "Agl23 flippase-associated protein-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Agl23-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060062": {"description": "DUF8230, N-terminal", "go_ids": [], "go_terms": [], "name": "DUF8230_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060063": {"description": "DUF8230, C-terminal", "go_ids": [], "go_terms": [], "name": "DUF8230_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060064": {"description": "MJ0043/EndoQ-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MJ0043/EndoQ-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060065": {"description": "DOCK6-11, TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_DOCK6-11", "pathway_ids": ["R-HSA-9013409", "R-HSA-8875555", "R-HSA-983231", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-MMU-983231", "R-HSA-9013404", "R-DRE-983231", "R-MMU-9013423", "R-HSA-9013149", "R-DRE-9013148", "R-MMU-8875555", "R-HSA-9013423", "R-HSA-9013148", "R-DRE-9013149", "R-MMU-9013149"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-HSA-8875555:r:MET activates RAP1 and RAC1", "R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-DRE-983231:r:Factors involved in megakaryocyte development and platelet production", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-DRE-9013148:r:CDC42 GTPase cycle", "R-MMU-8875555:r:MET activates RAP1 and RAC1", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-DRE-9013149:r:RAC1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle"], "type": "Domain"}, "IPR060066": {"description": "Adenylate cyclase, class-I, third domain", "go_ids": [], "go_terms": [], "name": "Adenylate_cycl_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060067": {"description": "Outer dense fiber protein 2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ODF2_N", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-MMU-380270", "R-HSA-380284", "R-HSA-380270", "R-RNO-5620912", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-RNO-380259", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR060068": {"description": "Adenylate cyclase, class-I, fourth domain", "go_ids": [], "go_terms": [], "name": "Adenylate_cycl_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060069": {"description": "Adenylate cyclase, class-I, C-terminal", "go_ids": [], "go_terms": [], "name": "Adenylate_cycl_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060070": {"description": "Competence protein ComGC, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ComGC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060071": {"description": "IPGAL1-like, C-terminal", "go_ids": [], "go_terms": [], "name": "IPGAL1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060072": {"description": "Rho GTPase-activating protein 18-like, N-terminal SAM domain", "go_ids": [], "go_terms": [], "name": "SAM_ARHGAP18_N", "pathway_ids": ["R-DME-9013148", "R-HSA-8980692", "R-HSA-9013106", "R-DME-8980692", "R-MMU-9013106", "R-MMU-8980692"], "pathways": ["R-DME-9013148:r:CDC42 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-DME-8980692:r:RHOA GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle"], "type": "Domain"}, "IPR060073": {"description": "DUF272, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF272_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060074": {"description": "EVI5-like domain", "go_ids": [], "go_terms": [], "name": "EVI5-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060075": {"description": "Afadin domain", "go_ids": [], "go_terms": [], "name": "AFDN_dom", "pathway_ids": ["R-RNO-418990", "R-HSA-418990", "R-MMU-418990"], "pathways": ["R-RNO-418990:r:Adherens junctions interactions", "R-HSA-418990:r:Adherens junctions interactions", "R-MMU-418990:r:Adherens junctions interactions"], "type": "Domain"}, "IPR060076": {"description": "C2orf42, C-terminal", "go_ids": [], "go_terms": [], "name": "C2orf42_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060078": {"description": "GCN1, HEAT repeat domain", "go_ids": [], "go_terms": [], "name": "HEAT_GCN1_2", "pathway_ids": ["R-HSA-9633012"], "pathways": ["R-HSA-9633012:r:Response of EIF2AK4 (GCN2) to amino acid deficiency"], "type": "Domain"}, "IPR060079": {"description": "Target of ERK kinase mpk-1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TOE2_C", "pathway_ids": ["R-HSA-9013409", "R-MMU-9035034", "R-HSA-9013405", "R-HSA-9013420", "R-HSA-9696270", "R-MMU-9013106", "R-MMU-8980692", "R-MMU-9013408", "R-MMU-9013424", "R-MMU-9013409", "R-MMU-9013148", "R-MMU-9013404", "R-HSA-9013106", "R-HSA-9013424", "R-HSA-9696264", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-8980692", "R-MMU-9013420", "R-MMU-9013406", "R-MMU-9013026", "R-HSA-9035034", "R-HSA-9013148", "R-HSA-9013026", "R-MMU-9696270", "R-MMU-9696264", "R-HSA-9013406", "R-MMU-9696273", "R-MMU-9013149", "R-HSA-9013408", "R-HSA-9696273"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-9035034:r:RHOF GTPase cycle", "R-HSA-9013405:r:RHOD GTPase cycle", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-9696270:r:RND2 GTPase cycle", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-MMU-9013409:r:RHOJ GTPase cycle", "R-MMU-9013148:r:CDC42 GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-HSA-9696264:r:RND3 GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-HSA-9035034:r:RHOF GTPase cycle", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-9696270:r:RND2 GTPase cycle", "R-MMU-9696264:r:RND3 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9696273:r:RND1 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-9696273:r:RND1 GTPase cycle"], "type": "Domain"}, "IPR060080": {"description": "E4 SUMO-protein ligase PIAL1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PIAL1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060082": {"description": "CUL7/CUL9, TPR repeat domain", "go_ids": [], "go_terms": [], "name": "TPR_CUL9", "pathway_ids": ["R-HSA-381038", "R-HSA-983168", "R-RNO-983168", "R-RNO-8951664", "R-HSA-8951664", "R-MMU-983168"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR060083": {"description": "F-box only protein 32/25, C-terminal domain", "go_ids": [], "go_terms": [], "name": "FBXO32/25_C", "pathway_ids": ["R-BTA-983168", "R-MMU-8951664", "R-BTA-8951664", "R-HSA-9615017", "R-SSC-983168", "R-RNO-8951664", "R-HSA-8951664", "R-RNO-983168", "R-MMU-983168", "R-SSC-8951664", "R-HSA-983168"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR060084": {"description": "F-box only protein 32/25, helical bundle domain", "go_ids": [], "go_terms": [], "name": "FBXO32/25_helical", "pathway_ids": ["R-BTA-983168", "R-MMU-8951664", "R-BTA-8951664", "R-HSA-9615017", "R-SSC-983168", "R-RNO-8951664", "R-HSA-8951664", "R-RNO-983168", "R-MMU-983168", "R-SSC-8951664", "R-HSA-983168"], "pathways": ["R-BTA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-8951664:r:Neddylation", "R-BTA-8951664:r:Neddylation", "R-HSA-9615017:r:FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-8951664:r:Neddylation", "R-HSA-8951664:r:Neddylation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-8951664:r:Neddylation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR060085": {"description": "Integrator complex subunit 8, TPR repeat domain", "go_ids": [], "go_terms": [], "name": "TPR_INTS8_M", "pathway_ids": ["R-DME-6807505", "R-MMU-6807505", "R-HSA-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR060086": {"description": "Integrator complex subunit 8, N-terminal TPR repeats", "go_ids": [], "go_terms": [], "name": "TPR_INTS8_N", "pathway_ids": ["R-DME-6807505", "R-MMU-6807505", "R-HSA-6807505"], "pathways": ["R-DME-6807505:r:RNA polymerase II transcribes snRNA genes", "R-MMU-6807505:r:RNA polymerase II transcribes snRNA genes", "R-HSA-6807505:r:RNA polymerase II transcribes snRNA genes"], "type": "Domain"}, "IPR060087": {"description": "BEGAIN-like, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "BEGAIN-like_coil", "pathway_ids": ["R-HSA-6794361"], "pathways": ["R-HSA-6794361:r:Neurexins and neuroligins"], "type": "Domain"}, "IPR060088": {"description": "PRD1-like, TPR repeat domain", "go_ids": [], "go_terms": [], "name": "TPR_PRD1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060089": {"description": "Ras guanine nucleotide exchange factor W, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "Helical_GefW", "pathway_ids": ["R-DDI-354192", "R-DDI-381676", "R-DDI-171007", "R-DDI-392517", "R-DDI-5673001", "R-DDI-9013423", "R-DDI-1169092", "R-DDI-9013149", "R-DDI-193648"], "pathways": ["R-DDI-354192:r:Integrin signaling", "R-DDI-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-DDI-171007:r:p38MAPK events", "R-DDI-392517:r:Rap1 signalling", "R-DDI-5673001:r:RAF/MAP kinase cascade", "R-DDI-9013423:r:RAC3 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Ubiquitination & Proteasome degradation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR060226": {"description": "NAD-protein ADP-ribosyltransferase ModA/ModB", "go_ids": [], "go_terms": [], "name": "ModA/B_ADP_RT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060227": {"description": "tRNA (adenine(9)-N1)-methyltransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TRM10_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060228": {"description": "tRNA (adenine(9)-N1)-methyltransferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TRM10_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060229": {"description": "Phage T5 A2 protein", "go_ids": [], "go_terms": [], "name": "Phage_T5_A2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060230": {"description": "Phage spanin outer lipoprotein subunit", "go_ids": [], "go_terms": [], "name": "Phage_T4_Spanin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060231": {"description": "Phage phiKMV holin", "go_ids": [], "go_terms": [], "name": "Phage_phiKMV_holin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060232": {"description": "NAD(+)--arginine ADP-ribosyltransferase, N-terminal", "go_ids": [], "go_terms": [], "name": "ADPRT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060233": {"description": "tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TRM10_Arch_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060234": {"description": "tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TRM10_Arch_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060235": {"description": "TP_0929, third domain", "go_ids": [], "go_terms": [], "name": "TP_0929_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060236": {"description": "Aq_aa27, P-loop NTPase domain", "go_ids": [], "go_terms": [], "name": "P-loop_Aq_aa27", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060237": {"description": "Phage P1 replication protein RepL", "go_ids": [], "go_terms": [], "name": "Phage_P1_RepL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060238": {"description": "Bacteriophage T5 5'-deoxynucleotidase", "go_ids": [], "go_terms": [], "name": "Phage_T5_dNMPase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060239": {"description": "Mycobacterium phage L5 gene 81 protein", "go_ids": [], "go_terms": [], "name": "Phage_L5_Gp81", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060240": {"description": "Bacteriophage T4 protein Y05C", "go_ids": [], "go_terms": [], "name": "Phage_T4_Y05C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060241": {"description": "Intimin, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig_Eae", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060242": {"description": "ABC transporter domain-containing protein-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ABC-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060243": {"description": "KilR, SH3-type barrel domain", "go_ids": [], "go_terms": [], "name": "SH3_KilR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060244": {"description": "Bacteriophage T4 protein 52.2", "go_ids": [], "go_terms": [], "name": "Phage_T4_Ac", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060245": {"description": "Ecto-NOX disulfide-thiol exchanger 1/2, C-terminal helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "HTH_ENOX1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060246": {"description": "MJECL01, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MJECL01_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060247": {"description": "PB2B2.08-like", "go_ids": [], "go_terms": [], "name": "PB2B2.08-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060248": {"description": "AF0774", "go_ids": [], "go_terms": [], "name": "AF0774", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060249": {"description": "S-layer protein A, third immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig-like_SlaA_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060250": {"description": "ODF2-like, C-terminal coiled coil domain", "go_ids": [], "go_terms": [], "name": "ODF2-like_C", "pathway_ids": ["R-MMU-380259", "R-RNO-8854518", "R-MMU-380270", "R-HSA-380284", "R-HSA-380270", "R-RNO-5620912", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-RNO-380259", "R-RNO-380320", "R-HSA-2565942", "R-HSA-380320", "R-RNO-2565942", "R-RNO-380284", "R-MMU-8854518", "R-MMU-5620912", "R-HSA-5620912", "R-HSA-380259", "R-RNO-380270"], "pathways": ["R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-8854518:r:AURKA Activation by TPX2", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR060251": {"description": "Cytidine deaminase-like, bacterial", "go_ids": [], "go_terms": [], "name": "CDL_bac", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060252": {"description": "Cullin-associated NEDD8-dissociated protein 1 N-terminal part, TPR domain", "go_ids": [], "go_terms": [], "name": "CandA_N_TPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060253": {"description": "TP_0324, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TP_0324_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060254": {"description": "BigA, fourth pectate lyase-like domain", "go_ids": [], "go_terms": [], "name": "BigA_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060255": {"description": "BigA, third pectate lyase-like domain", "go_ids": [], "go_terms": [], "name": "BigA_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060257": {"description": "TP_0855, helical bundle domain", "go_ids": [], "go_terms": [], "name": "TP_0855_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060258": {"description": "TP_0855, C-terminal", "go_ids": [], "go_terms": [], "name": "TP_0855_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060259": {"description": "Thioredoxin-like domain, nematodes", "go_ids": [], "go_terms": [], "name": "Thioredoxin-like_nematodes", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060260": {"description": "LB_356", "go_ids": [], "go_terms": [], "name": "LB_356", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060261": {"description": "YOL029C, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YOL029C_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060262": {"description": "UvrABC system protein B, third helical domain", "go_ids": [], "go_terms": [], "name": "UvrB_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060263": {"description": "Thioredoxin-like domain, plants", "go_ids": [], "go_terms": [], "name": "Thioredoxin-like_N_plants", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060264": {"description": "GPR137, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GPR137_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060265": {"description": "MimR-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MimR-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060266": {"description": "VPS35 endosomal protein-sorting factor-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "VPS35L_N", "pathway_ids": ["R-DDI-6798695", "R-MMU-6798695", "R-HSA-6798695", "R-DME-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR060267": {"description": "ELMO, N-terminal ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "ELMO_N", "pathway_ids": ["R-HSA-164944", "R-MMU-9013408", "R-HSA-9013408", "R-HSA-2029482", "R-MMU-4420097", "R-HSA-9664422", "R-MMU-8849471", "R-MMU-2029482", "R-HSA-8849471", "R-HSA-4420097"], "pathways": ["R-HSA-164944:r:Nef and signal transduction", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-MMU-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-8849471:r:PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR060268": {"description": "TatB, coiled-coil domain, Pasteurellaceae", "go_ids": [], "go_terms": [], "name": "TatB_CC_Pasteurellaceae", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060269": {"description": "Adaptation to cold protein A", "go_ids": [], "go_terms": [], "name": "AtcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060270": {"description": "Lipoteichoic acid synthase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LtaS_N", "pathway_ids": ["PWY-6580", "PWY-6350", "PWY-7817", "PWY-7981", "PWY-7819", "PWY-6804", "PWY-7820", "PWY-8248", "PWY-7816", "PWY-7818", "PWY-7815"], "pathways": ["PWY-6580:t:phosphatidylinositol biosynthesis I (bacteria)", "PWY-6350:t:archaetidylinositol biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-6804:t:diacylglycerol biosynthesis (PUFA enrichment in oilseed)", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"], "type": "Domain"}, "IPR060271": {"description": "GTF2H2, zinc ribbon domain", "go_ids": [], "go_terms": [], "name": "Zn_ribbon_GTF2H2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060272": {"description": "DnaJ homolog subfamily C member 16, thioredoxin-like domain 3", "go_ids": [], "go_terms": [], "name": "DJC16_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060273": {"description": "Gamma carbonic anhydrase 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GAMMACA1_C", "pathway_ids": ["PWY-7045", "PWY-8319", "PWY-7811", "PWY-6322", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7814", "PWY-6627", "PWY-6946", "PWY-6945", "PWY-7188", "PWY-5780", "PWY-7897", "PWY-7275", "PWY-5367", "PWY-8152", "PWY-8029", "PWY-6948", "PWY-8134", "PWY-7610", "PWY-7695", "PWY-7354", "PWY-8335", "PWY-6944", "PWY-7547", "PWY-8012", "PWY-2229", "PWY-5793", "PWY-7352", "PWY-2467", "PWY-8044", "PWY-6602", "PWY-6679", "PWY-7757", "PWY-7510", "PWY-5979", "PWY-721", "PWY-5644", "PWY-5408", "PWY-7821", "PWY-7189", "PWY-5410", "PWY-7613", "PWYG-321", "PWY-5061", "PWY-6721", "PWY-6672", "PWY-5409", "PWY-6749", "PWY-7428", "PWY-8151"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-8319:t:NiFe(CO)(CN)2 cofactor biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-7188:t:orientin and isoorientin biosynthesis I", "PWY-5780:t:hypericin biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-7275:t:L-homophenylalanine biosynthesis", "PWY-5367:t:petroselinate biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-8134:t:bile acid 7beta-dehydroxylation", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-8335:t:plasmalogen biosynthesis II (anaerobic)", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7547:t:prodigiosin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-2229:t:superpathway of pterocarpan biosynthesis (via formononetin)", "PWY-5793:t:maysin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-2467:t:(+)-pisatin biosynthesis", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-6602:t:naringenin C-glucosylation", "PWY-6679:t:jadomycin biosynthesis", "PWY-7757:t:bisphenol A degradation", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-5979:t:3-amino-5-hydroxybenzoate biosynthesis", "PWY-721:t:3-methylquinoline degradation", "PWY-5644:t:4-nitrotoluene degradation II", "PWY-5408:t:9-lipoxygenase and 9-hydroperoxide lyase pathway", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7189:t:pinocembrin C-glucosylation", "PWY-5410:t:traumatin and (Z)-3-hexen-1-yl acetate biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5061:t:6,7,4'-trihydroxyisoflavone biosynthesis", "PWY-6721:t:sangivamycin biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-5409:t:divinyl ether biosynthesis II", "PWY-6749:t:CMP-legionaminate biosynthesis I", "PWY-7428:t:2-chloroacrylate degradation II", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)"], "type": "Domain"}, "IPR060274": {"description": "DnaJ homolog subfamily C member 16, thioredoxin-like domain 2", "go_ids": [], "go_terms": [], "name": "DJC16_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060275": {"description": "DnaJ homolog subfamily C member 16, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DJC16_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060276": {"description": "Putative transmembrane protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TM-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060277": {"description": "CNOT10, TPR domain", "go_ids": [], "go_terms": [], "name": "CNOT10_TPR", "pathway_ids": ["R-HSA-6804115", "R-MMU-429947", "R-BTA-429947", "R-HSA-429947", "R-HSA-9820841", "R-MMU-6804115", "R-GGA-6804115", "R-DRE-6804115", "R-BTA-6804115", "R-GGA-429947", "R-RNO-6804115"], "pathways": ["R-HSA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-MMU-429947:r:Deadenylation of mRNA", "R-BTA-429947:r:Deadenylation of mRNA", "R-HSA-429947:r:Deadenylation of mRNA", "R-HSA-9820841:r:M-decay: degradation of maternal mRNAs by maternally stored factors", "R-MMU-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-GGA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-DRE-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-BTA-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-GGA-429947:r:Deadenylation of mRNA", "R-RNO-6804115:r:TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "type": "Domain"}, "IPR060278": {"description": "PDI-like, thioredoxin-like domain", "go_ids": [], "go_terms": [], "name": "Thioredoxin-like_PDI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060279": {"description": "Nucleoporin NUP37, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "NUP37_beta-prop", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060280": {"description": "ZNF608/609, beta-sheet domain", "go_ids": [], "go_terms": [], "name": "ZNF608/609_beta_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060281": {"description": "Synergin gamma, spectrin-like domain", "go_ids": [], "go_terms": [], "name": "Spectrin-like_SYNRG", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060282": {"description": "RecBCD enzyme subunit RecC, fourth domain", "go_ids": [], "go_terms": [], "name": "RecC_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060283": {"description": "FAM193A, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FAM193A_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060284": {"description": "Potassium efflux system KefB/KefC-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "KefB/KefC-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060285": {"description": "Protein-arginine kinase McsB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "McsB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060286": {"description": "TRPM8 channel-associated factor, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TCAF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060287": {"description": "Centrosomal protein of 295 kDa-like", "go_ids": [], "go_terms": [], "name": "CEP295-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060288": {"description": "GDP-mannose pyrophosphatase NudK, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NudK_N", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation"], "type": "Domain"}, "IPR060289": {"description": "Golgi SNAP receptor complex member, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GOSR1_N", "pathway_ids": ["R-BTA-6807878", "R-HSA-6811438", "R-MMU-6811438", "R-SCE-6807878", "R-RNO-6807878", "R-SCE-6811438", "R-RNO-6811438", "R-HSA-6807878", "R-CEL-6807878", "R-BTA-6811438", "R-CEL-6811438", "R-MMU-6807878", "R-DME-6807878", "R-DME-6811438"], "pathways": ["R-BTA-6807878:r:COPI-mediated anterograde transport", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-SCE-6811438:r:Intra-Golgi traffic", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-BTA-6811438:r:Intra-Golgi traffic", "R-CEL-6811438:r:Intra-Golgi traffic", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-DME-6811438:r:Intra-Golgi traffic"], "type": "Domain"}, "IPR060290": {"description": "BOS1/GOSR2/MEM11, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BOS1_GOSR2_MEM11-like_N", "pathway_ids": ["R-SPO-6807878", "R-MMU-204005", "R-HSA-381038", "R-RNO-5694530", "R-HSA-6811438", "R-MMU-6811438", "R-SCE-6807878", "R-CEL-5694530", "R-RNO-6807878", "R-MMU-5694530", "R-RNO-6811438", "R-HSA-6807878", "R-SCE-204005", "R-CEL-6807878", "R-SPO-204005", "R-SPO-5694530", "R-MMU-6807878", "R-DME-6811438", "R-HSA-5694530", "R-RNO-204005", "R-HSA-204005", "R-SCE-5694530", "R-CEL-204005", "R-CEL-6811438", "R-DME-6807878", "R-DME-5694530", "R-DME-204005"], "pathways": ["R-SPO-6807878:r:COPI-mediated anterograde transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-RNO-5694530:r:Cargo concentration in the ER", "R-HSA-6811438:r:Intra-Golgi traffic", "R-MMU-6811438:r:Intra-Golgi traffic", "R-SCE-6807878:r:COPI-mediated anterograde transport", "R-CEL-5694530:r:Cargo concentration in the ER", "R-RNO-6807878:r:COPI-mediated anterograde transport", "R-MMU-5694530:r:Cargo concentration in the ER", "R-RNO-6811438:r:Intra-Golgi traffic", "R-HSA-6807878:r:COPI-mediated anterograde transport", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-CEL-6807878:r:COPI-mediated anterograde transport", "R-SPO-204005:r:COPII-mediated vesicle transport", "R-SPO-5694530:r:Cargo concentration in the ER", "R-MMU-6807878:r:COPI-mediated anterograde transport", "R-DME-6811438:r:Intra-Golgi traffic", "R-HSA-5694530:r:Cargo concentration in the ER", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-SCE-5694530:r:Cargo concentration in the ER", "R-CEL-204005:r:COPII-mediated vesicle transport", "R-CEL-6811438:r:Intra-Golgi traffic", "R-DME-6807878:r:COPI-mediated anterograde transport", "R-DME-5694530:r:Cargo concentration in the ER", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR060291": {"description": "Bacteriophage T7 protein kinase 0.7", "go_ids": [], "go_terms": [], "name": "Phage_T7_kinase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060292": {"description": "TRPM8 channel-associated factor, alpha-helical domain", "go_ids": [], "go_terms": [], "name": "TCAF_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060293": {"description": "Trehalose phosphorylase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "TreT-like_N", "pathway_ids": ["PWY-2723"], "pathways": ["PWY-2723:t:trehalose degradation V"], "type": "Domain"}, "IPR060294": {"description": "Acyl-CoA N-acyltransferase VerG, N-terminal domain", "go_ids": [], "go_terms": [], "name": "VerG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060295": {"description": "TRS130-like, first Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TRS130-like_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060296": {"description": "Vertnin, middle domain", "go_ids": [], "go_terms": [], "name": "Vertnin_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060297": {"description": "VSTM5, C-terminal region", "go_ids": [], "go_terms": [], "name": "VSTM5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060298": {"description": "Protein unc-13 homolog, third domain", "go_ids": [], "go_terms": [], "name": "PATROL1_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060300": {"description": "HAUS3, coiled-coil", "go_ids": [], "go_terms": [], "name": "HAUS3_CC", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-2565942", "R-MMU-8854518", "R-HSA-380284", "R-DRE-380320", "R-MMU-380270", "R-MMU-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR060301": {"description": "CCPG1/PBIP1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CCPG1/PBIP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060302": {"description": "CCPG1/PBIP1 helical domain", "go_ids": [], "go_terms": [], "name": "CCPG1/PBIP_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060303": {"description": "HAUS3, C-terminal", "go_ids": [], "go_terms": [], "name": "HAUS3_C", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-2565942", "R-MMU-8854518", "R-HSA-380284", "R-DRE-380320", "R-MMU-380270", "R-MMU-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR060304": {"description": "Glycerol-3-phosphate acyltransferase PlsB, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PlsB_N", "pathway_ids": ["PWY-5667", "PWY-8053", "PWY-7587", "PWY-8051", "PWY-8055", "PWY-6453", "PWY-7411"], "pathways": ["PWY-5667:t:CDP-diacylglycerol biosynthesis I", "PWY-8053:t:anandamide biosynthesis II", "PWY-7587:t:oleate biosynthesis III (cyanobacteria)", "PWY-8051:t:anandamide biosynthesis I", "PWY-8055:t:palmitoyl ethanolamide biosynthesis", "PWY-6453:t:stigma estolide biosynthesis", "PWY-7411:t:phosphatidate biosynthesis (yeast)"], "type": "Domain"}, "IPR060306": {"description": "NUP42, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NUP42_C", "pathway_ids": ["R-HSA-180910", "R-XTR-4615885", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-DRE-3232142", "R-MMU-3232142", "R-DRE-159231", "R-MMU-4570464", "R-DRE-4551638", "R-XTR-159236", "R-HSA-170822", "R-HSA-1169408", "R-DRE-191859", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-DRE-159236", "R-DRE-3108214", "R-MMU-4085377", "R-HSA-3371453", "R-MMU-4551638", "R-HSA-165054", "R-HSA-4570464", "R-XTR-170822", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-XTR-191859", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-MMU-3301854", "R-XTR-3371453", "R-HSA-4085377", "R-HSA-168325", "R-XTR-4085377", "R-XTR-3301854", "R-HSA-9609690", "R-DRE-3371453", "R-MMU-170822", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-DRE-3301854", "R-DRE-159227", "R-HSA-5619107", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-XTR-3108214"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DRE-191859:r:snRNP Assembly", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-XTR-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-XTR-191859:r:snRNP Assembly", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-XTR-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9609690:r:HCMV Early Events", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-XTR-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Domain"}, "IPR060307": {"description": "Zinc finger transcription factor Trps1, third C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_Trps1_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060308": {"description": "C3orf18/SIM29 domain", "go_ids": [], "go_terms": [], "name": "C3orf18_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060309": {"description": "Zinc finger transcription factor Trps1, first C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_Trps1_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060310": {"description": "Cytoplasmic filament protein A, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CfpA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060311": {"description": "YycP, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "Beta-prop_YycP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060312": {"description": "TP_0593-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TP_0593-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060313": {"description": "TP_0752-like, middle domain", "go_ids": [], "go_terms": [], "name": "TP_0752-like_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060314": {"description": "TdpA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TdpA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060315": {"description": "Y4fE", "go_ids": [], "go_terms": [], "name": "Y4fE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060316": {"description": "MadH, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MadH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060317": {"description": "Zinc finger transcription factor Trps1, second C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_Trps1_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060318": {"description": "Zinc finger transcription factor Trps1, fourth C2H2 zinc finger", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_Trps1_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060319": {"description": "Rv3811-like, N-terminal galactose-binding domain-like", "go_ids": [], "go_terms": [], "name": "Rv3811-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060320": {"description": "DG1062/SHA-B, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DG1062/SHA-B_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060321": {"description": "Prephenate dehydrogenase [NADP(+)], C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tyr1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060322": {"description": "ATRAID-like, EGF-like domain", "go_ids": [], "go_terms": [], "name": "EGF_ATRAID_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060323": {"description": "Calsyntenin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ig_CLSTN_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060324": {"description": "ANTKMT, N-terminal", "go_ids": [], "go_terms": [], "name": "ANTKMT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060325": {"description": "Co-chaperone DjlA, transmembrane domain", "go_ids": [], "go_terms": [], "name": "DjlA_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060326": {"description": "Nucleoside triphosphate pyrophosphohydrolase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MazG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060327": {"description": "MHP1/GIP3/HER1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MHP1/GIP3/HER1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060328": {"description": "Anosmin-1, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig_ANOS1", "pathway_ids": ["R-GGA-190373", "R-HSA-190373", "R-HSA-5654726", "R-GGA-5654726"], "pathways": ["R-GGA-190373:r:FGFR1c ligand binding and activation", "R-HSA-190373:r:FGFR1c ligand binding and activation", "R-HSA-5654726:r:Negative regulation of FGFR1 signaling", "R-GGA-5654726:r:Negative regulation of FGFR1 signaling"], "type": "Domain"}, "IPR060330": {"description": "E3 ubiquitin-protein ligase RNF216, tri-helical domain", "go_ids": [], "go_terms": [], "name": "RNF216_N", "pathway_ids": ["R-HSA-936440"], "pathways": ["R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling"], "type": "Domain"}, "IPR060331": {"description": "ATR-interacting protein, N-terminal", "go_ids": [], "go_terms": [], "name": "ATRIP_N", "pathway_ids": ["R-MMU-69473", "R-HSA-9709570", "R-HSA-5693607", "R-HSA-6804756", "R-HSA-5693616", "R-HSA-69473", "R-MMU-176187", "R-HSA-5685938", "R-MMU-6804756", "R-HSA-6783310", "R-HSA-176187", "R-MMU-5685938", "R-MMU-5693607", "R-MMU-6783310"], "pathways": ["R-MMU-69473:r:G2/M DNA damage checkpoint", "R-HSA-9709570:r:Impaired BRCA2 binding to RAD51", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-5693616:r:Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-69473:r:G2/M DNA damage checkpoint", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-5685938:r:HDR through Single Strand Annealing (SSA)", "R-MMU-6804756:r:Regulation of TP53 Activity through Phosphorylation", "R-HSA-6783310:r:Fanconi Anemia Pathway", "R-HSA-176187:r:Activation of ATR in response to 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"R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-RNO-1236394:r:Signaling by ERBB4", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-182971:r:EGFR downregulation", 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"FimL, helical domain", "go_ids": [], "go_terms": [], "name": "FimL_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060394": {"description": "CsoS1D-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CsoS1D-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060395": {"description": "Metal-independent carbonic anhydrase domain", "go_ids": [], "go_terms": [], "name": "MICAH_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060396": {"description": "Nod factor export ATP-binding protein I, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NodI_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060397": {"description": "MNM1/HMG9-like, small beta-sheet domain", "go_ids": [], "go_terms": [], "name": "MNM1/HMG9-like_beta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060399": {"description": "RNA exonuclease 3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "REXO3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060400": {"description": "Dynein regulatory complex subunit 11-like, N-terminal", "go_ids": [], "go_terms": [], "name": "DRC11_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060401": {"description": "APC1, third domain, nematodes", "go_ids": [], "go_terms": [], "name": "APC1_3rd_nem", "pathway_ids": ["R-CEL-983168"], "pathways": ["R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR060402": {"description": "Guanine nucleotide exchange protein SMCR8, C-terminal", "go_ids": [], "go_terms": [], "name": "SMCR8_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060403": {"description": "APC1, N-terminal domain, nematodes", "go_ids": [], "go_terms": [], "name": "APC1_N_nem", "pathway_ids": ["R-CEL-983168"], "pathways": ["R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR060404": {"description": "CCDC17, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CCDC17_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060405": {"description": "CCDC17, middle coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CCDC17_middle_coil", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060406": {"description": "SLMAP-like, first coiled-coil", "go_ids": [], "go_terms": [], "name": "CC1_SLMAP-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060408": {"description": "MTUS1/CCDC69, second coiled-coil domain", "go_ids": [], "go_terms": [], "name": "MTUS1_CCDC69_CC2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060409": {"description": "CCDC69, first coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CCDC69_CC1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060410": {"description": "APC1, TPR-like domain", "go_ids": [], "go_terms": [], "name": "TPR_APC1", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-SPO-176408", "R-HSA-2467813", 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"R-SPO-196757:r:Metabolism of folate and pterines"], "type": "Domain"}, "IPR060422": {"description": "FliB lysine N-methylase, C-terminal", "go_ids": [], "go_terms": [], "name": "FliB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060423": {"description": "Cerebellar degeneration-related protein 2-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CDR2-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060424": {"description": "MG185/MG260-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MG185_MG260-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060425": {"description": "Ninein-like, middle domain", "go_ids": [], "go_terms": [], "name": "Ninein-like_mid", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], 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{"description": "MJECL34-like domain", "go_ids": [], "go_terms": [], "name": "MJECL34-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060427": {"description": "Ninein-like, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "Ninein-like_CC", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma 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[], "name": "GTT3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060438": {"description": "CEP162, third coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CEP162_coil_3", "pathway_ids": ["R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912"], "pathways": ["R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR060439": {"description": "YobJ family", "go_ids": [], "go_terms": [], "name": "YobJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060440": {"description": "CEP162, C-terminal coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CEP162_C", "pathway_ids": ["R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912"], "pathways": ["R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR060441": {"description": "CEP162, first coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CEP162_CC_1", "pathway_ids": ["R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912"], "pathways": ["R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR060442": {"description": "CEP162, second coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CEP162_CC_2", "pathway_ids": ["R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912"], "pathways": ["R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR060443": {"description": "Coiled-coil domain-containing protein SCD2, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "SCD2_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060444": {"description": "BrxC, C-terminal alpha-beta domain", "go_ids": [], "go_terms": [], "name": "BrxC_ab", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060445": {"description": "PARP10, KH-domain type I", "go_ids": [], "go_terms": [], "name": "KH_PARP10", "pathway_ids": ["R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631"], "pathways": ["R-HSA-196807:r:Nicotinate metabolism", "R-HSA-9683610:r:Maturation of nucleoprotein", "R-HSA-9694631:r:Maturation of nucleoprotein"], "type": "Domain"}, "IPR060446": {"description": "Adenylate cyclase activation protein git1-like, third TPR-like domain", "go_ids": [], "go_terms": [], "name": "Git1-like_TPR-like_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060447": {"description": "ORF11, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "ORF11_beta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060448": {"description": "Adenylate cyclase activation protein git1, second domain", "go_ids": [], "go_terms": [], "name": "Git1_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060449": {"description": "PTTG1IP, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PTTG1IP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060450": {"description": "Tubulin polyglutamylase TTLL11, EF-hand domain", "go_ids": [], "go_terms": [], "name": "EF_TTLL11", "pathway_ids": ["R-MMU-8955332", "R-HSA-8955332"], "pathways": ["R-MMU-8955332:r:Carboxyterminal post-translational modifications of tubulin", "R-HSA-8955332:r:Carboxyterminal post-translational modifications of tubulin"], "type": "Domain"}, "IPR060451": {"description": "Y4rL, C-terminal three-helical bundle", "go_ids": [], "go_terms": [], "name": "Y4rL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060452": {"description": "RP005-like, N-terminal alpha-helical domain", "go_ids": [], "go_terms": [], "name": "RP005_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060453": {"description": "YmtS, Rossmann-like domain", "go_ids": [], "go_terms": [], "name": "YmtS_Ross", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060454": {"description": "CROWDED NUCLEI 2-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CRWN-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060455": {"description": "Aq_493, lipocalin-like domain", "go_ids": [], "go_terms": [], "name": "Aq_493_lipo", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060456": {"description": "CSTPP1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CSTPP1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060457": {"description": "Fimbrial assembly protein FimB, N-terminal", "go_ids": [], "go_terms": [], "name": "FimB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060458": {"description": "Rv2576c-like, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Rv2576c_beta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060459": {"description": "Rv2311, SH3-like barrel domain", "go_ids": [], "go_terms": [], "name": "SH3_Rv2311", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060460": {"description": "BamI lipocalin-like domain", "go_ids": [], "go_terms": [], "name": "BamI_lipocalin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060461": {"description": "Aq_097-like, APC transporter", "go_ids": [], "go_terms": [], "name": "APC_Aq_097", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060462": {"description": "3-methyl-L-tyrosine peroxygenase", "go_ids": [], "go_terms": [], "name": "SfmD_perox", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060463": {"description": "YdhT, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YdhT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060464": {"description": "FlaEY, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "FlaEY_b-sand", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060465": {"description": "YjiT, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YjiT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060466": {"description": "SSP120-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SSP120-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060467": {"description": "ATP synthase subunit C lysine N-methyltransferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ATPSCKMT_N", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR060468": {"description": "5'-adenylylsulfate reductase-like 2-7, C-terminal domain", "go_ids": [], "go_terms": [], "name": "APRL2-7_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060469": {"description": "Coiled-coil domain-containing protein 43, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CCDC43_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060470": {"description": "S-layer protein A, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SlaA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060471": {"description": "MJ0874/BtuD-like", "go_ids": [], "go_terms": [], "name": "MJ0874/BtuD-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060472": {"description": "GreA-associated, TPR domain", "go_ids": [], "go_terms": [], "name": "GRAD_TPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060473": {"description": "ATP phosphoribosyltransferase subunit HisZ, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HisZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060474": {"description": "PSP1-like protein, third domain", "go_ids": [], "go_terms": [], "name": "PSP1_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060475": {"description": "TraD, C-terminal", "go_ids": [], "go_terms": [], "name": "TraD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060476": {"description": "Glycogen/maltodextrin phosphorylase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GlgP_C", "pathway_ids": ["PWY-7238", "PWY-6731", "PWY-5941", "PWY-6737"], "pathways": ["PWY-7238:t:sucrose biosynthesis II", "PWY-6731:t:starch degradation III", "PWY-5941:t:glycogen degradation II", "PWY-6737:t:starch degradation V"], "type": "Domain"}, "IPR060477": {"description": "Uncharacterized protein At4g13230-like", "go_ids": [], "go_terms": [], "name": "At4g13230-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060478": {"description": "DNA-binding protein Fis, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Fis_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060479": {"description": "EFCAB5, C-terminal domain", "go_ids": [], "go_terms": [], "name": "EFCAB5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060480": {"description": "DLEC1, helical domain", "go_ids": [], "go_terms": [], "name": "DLEC1_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060483": {"description": "WIP, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "WIP_coiled_coil", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060484": {"description": "CLU5d, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CLU5d_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060485": {"description": "Effector TSP1", "go_ids": [], "go_terms": [], "name": "TSP1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060486": {"description": "HYOU1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HYOU1_C", "pathway_ids": ["R-HSA-381038", "R-HSA-3000484", "R-RNO-3371453", "R-HSA-3371453", "R-BTA-3371453", "R-HSA-9918432", "R-CEL-3371453", "R-MMU-3371453"], "pathways": ["R-HSA-381038:r:XBP1(S) activates chaperone genes", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-BTA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CEL-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response"], "type": "Domain"}, "IPR060487": {"description": "Spore killer, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SPOK_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060488": {"description": "Pectate-lyase like, beta-helix domain", "go_ids": [], "go_terms": [], "name": "Beta_helix_4", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060489": {"description": "PMEPA1-like, helical domain", "go_ids": [], "go_terms": [], "name": "PMEPA1-like_helical", "pathway_ids": ["R-HSA-2173788", "R-MMU-2173788"], "pathways": ["R-HSA-2173788:r:Downregulation of TGF-beta receptor signaling", "R-MMU-2173788:r:Downregulation of TGF-beta receptor signaling"], "type": "Domain"}, "IPR060490": {"description": "Heat shock protein 15, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HSP15_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060491": {"description": "NADPH-dependent oxidoreductase NFRA-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NFRA-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060492": {"description": "TMEM260-associated domain 2", "go_ids": [], "go_terms": [], "name": "TMEM260_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060493": {"description": "BICD family-like cargo adapter 1/2-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BICDL1/2-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060494": {"description": "Nuclear envelope-associated protein, C-terminal", "go_ids": [], "go_terms": [], "name": "NEAP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060495": {"description": "Pyruvate dehydrogenase E1 component, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PDH_E1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060496": {"description": "Penicillin-binding protein-like, middle domain", "go_ids": [], "go_terms": [], "name": "PBP-like_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060497": {"description": "GspF/PilC, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GspF/PilC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060498": {"description": "Tail fiber assembly protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Caudo_TAP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060499": {"description": "Putative lipoprotein RzoQ", "go_ids": [], "go_terms": [], "name": "RzoQ", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060500": {"description": "Uncharacterized protein YdgU", "go_ids": [], "go_terms": [], "name": "YdgU", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060501": {"description": "ENDOD1 C-terminal coiled-coil domain", "go_ids": [], "go_terms": [], "name": "ENDOD1_C", "pathway_ids": ["R-HSA-114608", "R-MMU-114608"], "pathways": ["R-HSA-114608:r:Platelet degranulation", "R-MMU-114608:r:Platelet degranulation"], "type": "Domain"}, "IPR060502": {"description": "GH172, middle domain", "go_ids": [], "go_terms": [], "name": "GH172_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060503": {"description": "PAB, middle domain", "go_ids": [], "go_terms": [], "name": "PAB_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060504": {"description": "GH172, first beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "GH172_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060505": {"description": "PAB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PAB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060506": {"description": "CPR5, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CPR5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060507": {"description": "Meiosis inhibitor protein 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MEI1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060508": {"description": "Basic helix-loop-helix protein 144, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BHLH144_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060509": {"description": "Rv1828-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Rv1828-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060510": {"description": "ATA15/OSA15, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "ATA15/OSA15_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060511": {"description": "Large ribosomal subunit protein cL37, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PSRP5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060512": {"description": "At5g58720/SDE5-like, middle domain", "go_ids": [], "go_terms": [], "name": "At5g58720/SDE5-like_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060513": {"description": "O-fucosyltransferase 5/14/36, N-terminal helical domain", "go_ids": [], "go_terms": [], "name": "OFUT-14-like_helical_N", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR060515": {"description": "GIGANTEA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GIGANTEA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060516": {"description": "Mitochondrial nucleoid-associated protein 1, zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_MTNAP1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060517": {"description": "CCDC162, middle domain", "go_ids": [], "go_terms": [], "name": "CCDC162_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060518": {"description": "At4g04980, N-terminal domain", "go_ids": [], "go_terms": [], "name": "At4g04980_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060519": {"description": "IL27RA, third fibronectin type-III domain", "go_ids": [], "go_terms": [], "name": "IL27RA_FN3_3", "pathway_ids": ["R-MMU-8984722", "R-HSA-8984722", "R-MMU-9020956", "R-HSA-9020956"], "pathways": ["R-MMU-8984722:r:Interleukin-35 Signalling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-9020956:r:Interleukin-27 signaling"], "type": "Domain"}, "IPR060520": {"description": "C3H7.08c, C-terminal domain", "go_ids": [], "go_terms": [], "name": "C3H7_08c_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060521": {"description": "SKIP35, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SKIP35_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060522": {"description": "AF_0619-like, ribbon-helix-helix protein", "go_ids": [], "go_terms": [], "name": "RHH_12", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060523": {"description": "Maltose excess protein 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MEX1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060524": {"description": "McrB, alpha-helical lid domain", "go_ids": [], "go_terms": [], "name": "McrB_lid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060525": {"description": 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"R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-RNO-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-RNO-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-RNO-380270:r:Recruitment of mitotic centrosome proteins and complexes"], "type": "Domain"}, "IPR060528": {"description": "Trigger factor, FKBP-like domain", "go_ids": [], "go_terms": [], "name": "FKBP-like_TF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060529": {"description": "Protein downstream neighbor of Son domain", "go_ids": [], "go_terms": [], "name": "DONSON_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060530": {"description": "Probable ATP-dependent RNA helicase, helical domain", "go_ids": [], "go_terms": [], "name": "Helicase_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060531": {"description": "Probable trigger factor, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TF_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060532": {"description": "Ubiquitin-associated protein 2, UBA domain", "go_ids": [], "go_terms": [], "name": "UBA_UBAP2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060533": {"description": "YPL277C-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YPL277C-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060534": {"description": "SusR, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SusR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060535": {"description": "Aq_493, helical needle domain", "go_ids": [], "go_terms": [], "name": "Aq_493_helical_needle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060536": {"description": "TonB, transmembrane helix", "go_ids": [], "go_terms": [], "name": "1TM_TonB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060537": {"description": "YPL277C-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YPL277C-like_C", 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{"description": "tRNA(Ile)-lysidine synthase, SCL domain", "go_ids": [], "go_terms": [], "name": "TilS_SCL", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060541": {"description": "Probable helicase, winged helix domain", "go_ids": [], "go_terms": [], "name": "WH_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060542": {"description": "Probable helicase domain", "go_ids": [], "go_terms": [], "name": "Helicase_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060543": {"description": "YacL/YCF81-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YacL/YCF81-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060544": {"description": "BIG1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BIG1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060545": {"description": "RPM1 interacting protein 13, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RIN13_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060547": {"description": "ATPase synthesis protein 25, C-terminal TPR domain", "go_ids": [], "go_terms": [], "name": "TPR_Atp25_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060548": {"description": "CEP131, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CEP131_CC", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-DRE-380320", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the 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{"description": "POLR1D, N-terminal domain", "go_ids": [], "go_terms": [], "name": "POLR1D_N", "pathway_ids": ["R-HSA-76071", "R-HSA-73772", "R-HSA-73863", "R-HSA-76066", "R-HSA-73980", "R-HSA-427413", "R-HSA-1834949", "R-HSA-5250924", "R-HSA-76061", "R-HSA-73780", "R-HSA-749476", "R-HSA-73762"], "pathways": ["R-HSA-76071:r:RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-73772:r:RNA Polymerase I Promoter Escape", "R-HSA-73863:r:RNA Polymerase I Transcription Termination", "R-HSA-76066:r:RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-73980:r:RNA Polymerase III Transcription Termination", "R-HSA-427413:r:NoRC negatively regulates rRNA expression", "R-HSA-1834949:r:Cytosolic sensors of pathogen-associated DNA", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-HSA-76061:r:RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-73780:r:RNA Polymerase III Chain Elongation", "R-HSA-749476:r:RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-73762:r:RNA Polymerase I Transcription Initiation"], "type": "Domain"}, "IPR060591": {"description": "F-box protein SKIP28-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SKIP28-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060592": {"description": "Long chronological lifespan protein 2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LCL2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060593": {"description": "Plastid division protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PDV_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060594": {"description": "Zinc finger TRAF-type-containing protein 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CYHR1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060596": {"description": "At5g19025-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "At5g19025_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060597": {"description": "Nephrocystin-4, second C2-like domain", "go_ids": [], "go_terms": [], "name": "NPHP4_C2_2nd", "pathway_ids": ["R-MMU-2028269", "R-HSA-2028269", "R-MMU-5620912", "R-HSA-5620912"], "pathways": ["R-MMU-2028269:r:Signaling by Hippo", "R-HSA-2028269:r:Signaling by Hippo", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR060598": {"description": "Fibronectin type III domain-containing protein 9, helical domain", "go_ids": [], "go_terms": [], "name": "FNDC9_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060600": {"description": "Fibronectin type III domain-containing protein 9", "go_ids": [], "go_terms": [], "name": "FNDC9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060601": {"description": "Transmembrane protein 98, N-terminal helical domain", "go_ids": [], "go_terms": [], "name": "TMEM98_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060603": {"description": "Early responsive to dehydration 15 domain", "go_ids": [], "go_terms": [], "name": "ERD15_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060605": {"description": "Glycoprotein integral membrane protein 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GINM1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060606": {"description": "Glycoprotein integral membrane protein 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GINM1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060612": {"description": "XRI1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "XRI1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060613": {"description": "Probable acyl-activating enzyme 17/18-like, SAM domain", "go_ids": [], "go_terms": [], "name": "SAM_AAE17_18-like", "pathway_ids": ["PWY-8319", "PWY-7007", "PWY-735", "PWY-7769", "PWY-8424", "PWY-8361", "PWY-7462", "PWY-6722", "PWY-6799", "PWY-5924", "PWY-5752", "PWY-6670", "PWY-8374", "PWY-8463", "PWY-5923", "PWY-5045", "PWY-8029", "PWY-8336", "PWY-8152", "PWY-6948", "PWY-7536", "PWY-8443", "PWY-7620", "PWY-8293", "PWY-7660", "PWY-7288", "PWY-6593", "PWY-5136", "PWY-8044", "PWY-7671", "PWY-6457", "PWY-7778", "PWY-8042", "PWY-8045", "PWY-7738", "PWY-8032", "PWY-301", "PWY-8033", "PWY-5927", "PWY-5922", "PWY-7693", "PWYG-321", "PWY-8339", "PWY-8343", "PWY-5660", "PWY-7659", "PWY-8179", "PWY-8151", "PWY-8034", "PWY-5958", "PWY-6926", "PWY-7779"], "pathways": ["PWY-8319:t:NiFe(CO)(CN)2 cofactor biosynthesis", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-8361:t:apratoxin A biosynthesis", "PWY-7462:t:3,3'-disulfanediyldipropannoate degradation", "PWY-6722:t:candicidin biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-5924:t:limonene degradation II (L-limonene)", "PWY-5752:t:piperine biosynthesis", "PWY-6670:t:citronellol degradation", "PWY-8374:t:antimycin biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5923:t:limonene degradation I (D-limonene)", "PWY-5045:t:pinosylvin metabolism", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-8336:t:valinomycin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7536:t:2-amino-3-hydroxycyclopent-2-enone biosynthesis", "PWY-8443:t:cyclosporin A biosynthesis", "PWY-7620:t:naphthalene degradation (anaerobic)", "PWY-8293:t:alazopeptin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6593:t:sulfoacetate degradation", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-6457:t:cinnamoyl-CoA biosynthesis", "PWY-7778:t:2-methylpropene degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-301:t:cyclohexane-1-carboxylate degradation (anaerobic)", "PWY-8033:t:aureothin biosynthesis", "PWY-5927:t:(4S)-carveol and (4S)-dihydrocarveol degradation", "PWY-5922:t:(4R)-carveol and (4R)-dihydrocarveol degradation", "PWY-7693:t:guadinomine B biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-8343:t:leinamycin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8034:t:spectinabilin biosynthesis", "PWY-5958:t:acridone alkaloid biosynthesis", "PWY-6926:t:pyrethrin I biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation"], "type": "Domain"}, "IPR060614": {"description": "Probable acyl-activating enzyme 17/18-like", "go_ids": [], "go_terms": [], "name": "AAE17_18-like", "pathway_ids": ["PWY-8319", "PWY-7007", "PWY-735", "PWY-7769", "PWY-8424", "PWY-8361", "PWY-7462", "PWY-6722", "PWY-6799", "PWY-5924", "PWY-5752", "PWY-6670", "PWY-8374", "PWY-8463", "PWY-5923", "PWY-5045", "PWY-8029", "PWY-8336", "PWY-8152", "PWY-6948", "PWY-7536", "PWY-8443", "PWY-7620", "PWY-8293", "PWY-7660", "PWY-7288", "PWY-6593", "PWY-5136", "PWY-8044", "PWY-7671", "PWY-6457", "PWY-7778", "PWY-8042", "PWY-8045", "PWY-7738", "PWY-8032", "PWY-301", "PWY-8033", "PWY-5927", "PWY-5922", "PWY-7693", "PWYG-321", "PWY-8339", "PWY-8343", "PWY-5660", "PWY-7659", "PWY-8179", "PWY-8151", "PWY-8034", "PWY-5958", "PWY-6926", "PWY-7779"], "pathways": ["PWY-8319:t:NiFe(CO)(CN)2 cofactor biosynthesis", "PWY-7007:t:methyl ketone biosynthesis (engineered)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7769:t:phosalacine biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-8361:t:apratoxin A biosynthesis", "PWY-7462:t:3,3'-disulfanediyldipropannoate degradation", "PWY-6722:t:candicidin biosynthesis", "PWY-6799:t:fatty acid biosynthesis initiation (plant mitochondria)", "PWY-5924:t:limonene degradation II (L-limonene)", "PWY-5752:t:piperine biosynthesis", "PWY-6670:t:citronellol degradation", "PWY-8374:t:antimycin biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5923:t:limonene degradation I (D-limonene)", "PWY-5045:t:pinosylvin metabolism", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-8336:t:valinomycin biosynthesis", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7536:t:2-amino-3-hydroxycyclopent-2-enone biosynthesis", "PWY-8443:t:cyclosporin A biosynthesis", "PWY-7620:t:naphthalene degradation (anaerobic)", "PWY-8293:t:alazopeptin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6593:t:sulfoacetate degradation", "PWY-5136:t:fatty acid beta-oxidation II (plant peroxisome)", "PWY-8044:t:cyclohexane-1-carboxyl-CoA biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-6457:t:cinnamoyl-CoA biosynthesis", "PWY-7778:t:2-methylpropene degradation", "PWY-8042:t:acylceramide biosynthesis and processing", "PWY-8045:t:cylindrospermopsin biosynthesis", "PWY-7738:t:polyacyltrehalose biosynthesis", "PWY-8032:t:chloramphenicol biosynthesis", "PWY-301:t:cyclohexane-1-carboxylate degradation (anaerobic)", "PWY-8033:t:aureothin biosynthesis", "PWY-5927:t:(4S)-carveol and (4S)-dihydrocarveol degradation", "PWY-5922:t:(4R)-carveol and (4R)-dihydrocarveol degradation", "PWY-7693:t:guadinomine B biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-8339:t:gamma-butyrobetaine degradation III", "PWY-8343:t:leinamycin biosynthesis", "PWY-5660:t:taxol biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-8179:t:platensimycin biosynthesis", "PWY-8151:t:cholesterol degradation to androstenedione III (anaerobic)", "PWY-8034:t:spectinabilin biosynthesis", "PWY-5958:t:acridone alkaloid biosynthesis", "PWY-6926:t:pyrethrin I biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation"], "type": "Family"}, "IPR060615": {"description": "Transcription factor ATEG_07667-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ATEG07667-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060616": {"description": "Cramped, PI3K-like domain", "go_ids": [], "go_terms": [], "name": "Cramped_PI3K-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060617": {"description": "SAGA-associated factor 11-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Sgf11-like_C", "pathway_ids": ["R-HSA-3214847"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones"], "type": "Domain"}, "IPR060618": {"description": "Reprimo-like, transmembrane helix domain", "go_ids": [], "go_terms": [], "name": "Reprimo-like_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060619": {"description": "Protodermal factor 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PDF1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060620": {"description": "Mediator of RNA polymerase II transcription subunit 33, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MED33_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060621": {"description": "Mediator of RNA polymerase II transcription subunit 33, middle TPR-like domain", "go_ids": [], "go_terms": [], "name": "MED33_TPR-like_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060622": {"description": "Mediator of RNA polymerase II transcription subunit 33, second TPR-like domain", "go_ids": [], "go_terms": [], "name": "MED33_TPR-like_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060623": {"description": "Uncharacterised 80 kDa protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Y80K_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060624": {"description": "MSB2-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MSB2-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060625": {"description": "Ino eighty subunit 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "IES1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060627": {"description": "Ino eighty subunit 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ies1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060628": {"description": "Ino eighty subunit 1, helical domain", "go_ids": [], "go_terms": [], "name": "Ies1_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060630": {"description": "BACC1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BACC1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060631": {"description": "Dynein axonemal intermediate chain 3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DNAI3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060632": {"description": "CACHD1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CACHD1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060633": {"description": "EID1-like F-box protein 1-3-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "EID1-3-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060635": {"description": "Enhanced level of genomic instability 1 domain", "go_ids": [], "go_terms": [], "name": "ELG1_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060636": {"description": "Enhanced level of genomic instability 1-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ELG1-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060638": {"description": "EvC complex member EVC, N-terminal domain", "go_ids": [], "go_terms": [], "name": "EVC_N", "pathway_ids": ["R-HSA-5635838", "R-HSA-5632684", "R-MMU-5632684"], "pathways": ["R-HSA-5635838:r:Activation of SMO", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-5632684:r:Hedgehog 'on' state"], "type": "Domain"}, "IPR060639": {"description": "EvC complex member EVC, C-terminal domain", "go_ids": [], "go_terms": [], "name": "EVC_C", "pathway_ids": ["R-HSA-5635838", "R-HSA-5632684", "R-MMU-5632684"], "pathways": ["R-HSA-5635838:r:Activation of SMO", "R-HSA-5632684:r:Hedgehog 'on' state", "R-MMU-5632684:r:Hedgehog 'on' state"], "type": "Domain"}, "IPR060640": {"description": "Arabinogalactan protein 13/21/23/40", "go_ids": [], "go_terms": [], "name": "AGP13/21/23/40", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060641": {"description": "SPBC1E8.03c, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SPBC1E8_03c_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060642": {"description": "SPBC1E8.03c, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SPBC1E8_03c_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060643": {"description": "MAP3K12-binding inhibitory protein 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MBIP_N", "pathway_ids": ["R-HSA-3214847", "R-MMU-9772755", "R-HSA-9772755"], "pathways": ["R-HSA-3214847:r:HATs acetylate histones", "R-MMU-9772755:r:Formation of WDR5-containing histone-modifying complexes", "R-HSA-9772755:r:Formation of WDR5-containing histone-modifying complexes"], "type": "Domain"}, "IPR060644": {"description": "Proheparin-binding EGF-like growth factor, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HBEGF_C", "pathway_ids": ["R-MMU-1250342", "R-SSC-1963642", "R-MMU-6785631", "R-MMU-8856828", "R-MMU-182971", "R-MMU-180336", "R-RNO-1250347", "R-GGA-1963642", "R-HSA-180292", "R-SSC-2179392", "R-MMU-6811558", "R-HSA-8856828", "R-RNO-9009391", "R-SSC-1250347", "R-MMU-9009391", "R-HSA-2179392", "R-GGA-1227986", "R-RNO-8863795", "R-SSC-9009391", "R-SSC-6811558", "R-SSC-1236394", "R-RNO-8847993", "R-RNO-6811558", "R-SSC-180336", "R-RNO-2179392", "R-HSA-8863795", "R-GGA-9009391", "R-RNO-1963642", "R-GGA-2179392", "R-HSA-177929", "R-SSC-8857538", "R-MMU-1236394", "R-HSA-9664565", "R-RNO-5673001", "R-RNO-8857538", "R-MMU-5673001", "R-GGA-8856828", "R-HSA-212718", "R-GGA-180292", "R-RNO-212718", "R-GGA-212718", "R-RNO-179812", "R-GGA-5673001", "R-SSC-6785631", "R-HSA-182971", "R-HSA-9665686", "R-MMU-180292", "R-GGA-8857538", "R-HSA-8847993", "R-HSA-2219530", "R-HSA-5673001", "R-HSA-6811558", "R-SSC-1250342", "R-SSC-8847993", "R-SSC-212718", "R-MMU-179812", "R-MMU-1963642", "R-MMU-1250196", "R-HSA-1257604", "R-HSA-179812", "R-GGA-179812", "R-HSA-8857538", "R-SSC-1227986", "R-SSC-1257604", "R-MMU-8863795", "R-MMU-2179392", "R-HSA-5638303", "R-RNO-6785631", "R-MMU-8856825", "R-HSA-1251985", "R-RNO-1257604", "R-GGA-1963640", "R-HSA-1250342", "R-HSA-1250347", "R-GGA-6785631", "R-GGA-8863795", "R-MMU-8847993", "R-HSA-5336415", "R-MMU-1250347", "R-HSA-1963642", "R-GGA-6811558", "R-HSA-1250196", "R-SSC-8856825", "R-RNO-8856828", "R-RNO-177929", "R-GGA-180336", "R-SSC-1250196", "R-SSC-8863795", "R-GGA-1257604", "R-GGA-1250196", "R-HSA-1963640", "R-SSC-179812", "R-RNO-8856825", "R-MMU-177929", "R-GGA-8856825", "R-RNO-1963640", "R-RNO-1250342", "R-MMU-1227986", "R-RNO-1227986", "R-HSA-6785631", "R-HSA-1227986", "R-MMU-1257604", "R-RNO-180292", "R-HSA-9634638", "R-HSA-180336", "R-SSC-177929", "R-HSA-1236394", "R-GGA-177929", "R-SSC-5673001", "R-MMU-212718", "R-SSC-1963640", "R-SSC-8856828", "R-HSA-9009391", "R-GGA-1250347", "R-HSA-8856825", "R-RNO-180336", "R-RNO-1236394", "R-SSC-180292", "R-GGA-182971", "R-RNO-1250196", "R-RNO-182971", "R-GGA-1236394", "R-SSC-182971", "R-MMU-8857538", "R-GGA-1250342", "R-MMU-1963640"], "pathways": ["R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-SSC-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-182971:r:EGFR downregulation", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-SSC-2179392:r:EGFR Transactivation by Gastrin", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-2179392:r:EGFR Transactivation by Gastrin", "R-GGA-1227986:r:Signaling by ERBB2", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-SSC-9009391:r:Extra-nuclear estrogen signaling", "R-SSC-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-1236394:r:Signaling by ERBB4", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-180336:r:SHC1 events in EGFR signaling", "R-RNO-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-GGA-9009391:r:Extra-nuclear estrogen signaling", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-GGA-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-177929:r:Signaling by EGFR", "R-SSC-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-1236394:r:Signaling by ERBB4", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-RNO-8857538:r:PTK6 promotes HIF1A stabilization", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-GGA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-GGA-180292:r:GAB1 signalosome", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-GGA-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-GGA-5673001:r:RAF/MAP kinase cascade", "R-SSC-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-182971:r:EGFR downregulation", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-180292:r:GAB1 signalosome", "R-GGA-8857538:r:PTK6 promotes HIF1A stabilization", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-SSC-1250342:r:PI3K events in ERBB4 signaling", "R-SSC-8847993:r:ERBB2 Activates PTK6 Signaling", "R-SSC-212718:r:EGFR interacts with phospholipase C-gamma", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-GGA-179812:r:GRB2 events in EGFR signaling", "R-HSA-8857538:r:PTK6 promotes HIF1A stabilization", "R-SSC-1227986:r:Signaling by ERBB2", "R-SSC-1257604:r:PIP3 activates AKT signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-2179392:r:EGFR Transactivation by Gastrin", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-GGA-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-GGA-6785631:r:ERBB2 Regulates Cell Motility", "R-GGA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-5336415:r:Uptake and function of diphtheria toxin", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-GGA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-SSC-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-177929:r:Signaling by EGFR", "R-GGA-180336:r:SHC1 events in EGFR signaling", "R-SSC-1250196:r:SHC1 events in ERBB2 signaling", "R-SSC-8863795:r:Downregulation of ERBB2 signaling", "R-GGA-1257604:r:PIP3 activates AKT signaling", "R-GGA-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-SSC-179812:r:GRB2 events in EGFR signaling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-177929:r:Signaling by EGFR", "R-GGA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-1227986:r:Signaling by ERBB2", "R-RNO-1227986:r:Signaling by ERBB2", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-1227986:r:Signaling by ERBB2", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-SSC-177929:r:Signaling by EGFR", "R-HSA-1236394:r:Signaling by ERBB4", "R-GGA-177929:r:Signaling by EGFR", "R-SSC-5673001:r:RAF/MAP kinase cascade", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-SSC-1963640:r:GRB2 events in ERBB2 signaling", "R-SSC-8856828:r:Clathrin-mediated endocytosis", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-GGA-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-RNO-1236394:r:Signaling by ERBB4", "R-SSC-180292:r:GAB1 signalosome", "R-GGA-182971:r:EGFR downregulation", "R-RNO-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-182971:r:EGFR downregulation", "R-GGA-1236394:r:Signaling by ERBB4", "R-SSC-182971:r:EGFR downregulation", "R-MMU-8857538:r:PTK6 promotes HIF1A stabilization", "R-GGA-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling"], "type": "Domain"}, "IPR060647": {"description": "DLEC1, sixth Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_DLEC1_6th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060648": {"description": "Glycyl-tRNA synthetase, insertion domain 1", "go_ids": [], "go_terms": [], "name": "GlyRS_ins_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060649": {"description": "CRISPR type IV associated protein Csf3", "go_ids": [], "go_terms": [], "name": "Csf3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060650": {"description": "Rho guanine nucleotide exchange factor 40-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ARHGEF40-like_N", "pathway_ids": ["R-HSA-193648", "R-HSA-416482", 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["R-HSA-9018519:r:Estrogen-dependent gene expression"], "type": "Domain"}, "IPR060654": {"description": "3-deoxy-D-manno-octulosonic acid transferase WaaZ", "go_ids": [], "go_terms": [], "name": "WaaZ_KDO_III", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060655": {"description": "LOC1, C-terminal", "go_ids": [], "go_terms": [], "name": "LOC1_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060656": {"description": "IgSF3/IGSF8/FPRP, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig_IgSF3/IGSF8/FPRP", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060657": {"description": "NNF2-like, helical region", "go_ids": [], "go_terms": [], "name": "NNF2_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060658": {"description": "pH-response transcription factor PacC/RIM101, C-terminal", "go_ids": [], "go_terms": [], "name": "PacC_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060659": {"description": "CCDC136/SLMAP, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CCDC136/SLMAP_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060660": {"description": "Semaphorin-3/4/7A-like, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "Ig_SEMA33/4/7A", "pathway_ids": ["R-DRE-416572", "R-DRE-416550", "R-HSA-416700", "R-MMU-416700", "R-MMU-416572", "R-MMU-416550"], "pathways": ["R-DRE-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-DRE-416550:r:Sema4D mediated inhibition of cell attachment and migration", "R-HSA-416700:r:Other semaphorin interactions", "R-MMU-416700:r:Other semaphorin interactions", "R-MMU-416572:r:Sema4D induced cell migration and growth-cone collapse", "R-MMU-416550:r:Sema4D mediated inhibition of cell attachment and migration"], "type": "Domain"}, "IPR060661": {"description": "DRC9/10, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DRC9/10_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060662": {"description": "COBRA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "COBRA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060663": {"description": "Retinitis pigmentosa 9 protein, N-terminal", "go_ids": [], "go_terms": [], "name": "RP9_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060664": {"description": "Retinitis pigmentosa 9 protein, C-terminal", "go_ids": [], "go_terms": [], "name": "RP9_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060665": {"description": "At5g65660-like, transmembrane helix", "go_ids": [], "go_terms": [], "name": "At5g65660_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060666": {"description": "SKA3, N-terminal", "go_ids": [], "go_terms": [], "name": "SKA3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060667": {"description": "CRISPR-associated endoribonuclease Cas13a, N-terminal", "go_ids": [], "go_terms": [], "name": "Cas13a_endoribonuclease_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060669": {"description": "PF3D7_0210200, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PF3D7_0210200_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060670": {"description": "PEX8-like, central TPR-like domain", "go_ids": [], "go_terms": [], "name": "PEX8_TPR_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060671": {"description": "EVI2B, conserved region", "go_ids": [], "go_terms": [], "name": "EVI2B_conserved", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060672": {"description": "Anti-phage protein ZorA-like", "go_ids": [], "go_terms": [], "name": "ZorA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060673": {"description": "HrpV-like, gammaproteobacteria", "go_ids": [], "go_terms": [], "name": "HrpV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060674": {"description": "Qat anti-phage system associated protein 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"Family"}, "IPR060689": {"description": "Ucp12-like, UBA domain", "go_ids": [], "go_terms": [], "name": "UBA_Ucp12", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060690": {"description": "ERVK-8-like, RNaseH-like domain", "go_ids": [], "go_terms": [], "name": "RNaseH_ERVK-8", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060691": {"description": "Uncharacterised conserved protein UCP028438-like", "go_ids": [], "go_terms": [], "name": "UCP028438-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060693": {"description": "Trehalose monomycolate transport factor TtfA", "go_ids": [], "go_terms": [], "name": "Treh_trans_TtfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060695": {"description": "HetZ-like", "go_ids": [], "go_terms": [], "name": "HetZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060696": {"description": "Probable transporter, periplasmic core domain", "go_ids": [], "go_terms": [], "name": "PCD-like", 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"Domain"}, "IPR060699": {"description": "RNA-binding protein 48, helix domain", "go_ids": [], "go_terms": [], "name": "RBM48_helix", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060700": {"description": "Type III secretion systems effector SseF/SseG", "go_ids": [], "go_terms": [], "name": "SseF_SseG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060701": {"description": "BV97_02767-like", "go_ids": [], "go_terms": [], "name": "BV97_02767-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060702": {"description": "HI_1480", "go_ids": [], "go_terms": [], "name": "HI_1480", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060703": {"description": "FcpA-like", "go_ids": [], "go_terms": [], "name": "FcpA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060704": {"description": "Uncharacterised conserved protein UCP029691-like", "go_ids": [], "go_terms": [], "name": "UCP029691-like", "pathway_ids": [], "pathways": [], "type": 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protein 1/2/D7/Stress-induced protein KIN1/2-like", "go_ids": [], "go_terms": [], "name": "LEA1_2_D7_KIN1/2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060719": {"description": "Non-structural protein ORF4b/Non-structural protein 3c, bat coronavirus-like", "go_ids": [], "go_terms": [], "name": "ORF4b_HKU5-Bat-CoV-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060720": {"description": "Accessory protein NS6, delta/gammacoronavirus", "go_ids": [], "go_terms": [], "name": "NS6_delta/gamma_CoV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060721": {"description": "Novel STAND NTPase 7", "go_ids": [], "go_terms": [], "name": "nSTAND_NTPase7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060722": {"description": "Magnetosome protein MamG/MamD-like", "go_ids": [], "go_terms": [], "name": "MamG/MamD-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060723": {"description": "Dispersin", "go_ids": [], "go_terms": [], "name": "Dispersin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060724": {"description": "Protein DVU_0533", "go_ids": [], "go_terms": [], "name": "DVU_0533", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060725": {"description": "General secretion pathway protein N-like", "go_ids": [], "go_terms": [], "name": "XpsN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060726": {"description": "Transmembrane cell adhesion receptor mua-3-like, EGF-like domain", "go_ids": [], "go_terms": [], "name": "EGF_Mua-3", "pathway_ids": ["R-CEL-216083", "R-CEL-1474228", "R-CEL-2129379", "R-CEL-8957275", "R-CEL-381426", "R-CEL-1566948", "R-CEL-2173789"], "pathways": ["R-CEL-216083:r:Integrin cell surface interactions", "R-CEL-1474228:r:Degradation of the extracellular matrix", "R-CEL-2129379:r:Molecules associated with elastic fibres", "R-CEL-8957275:r:Post-translational protein phosphorylation", "R-CEL-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-CEL-1566948:r:Elastic fibre formation", "R-CEL-2173789:r:TGF-beta receptor signaling activates SMADs"], "type": "Domain"}, "IPR060734": {"description": "GbsR-like, C-terminal helical hairpin", "go_ids": [], "go_terms": [], "name": "GbsR-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060735": {"description": "YjaZ", "go_ids": [], "go_terms": [], "name": "YjaZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060736": {"description": "Uridylyltransferase GlnD, third domain", "go_ids": [], "go_terms": [], "name": "GlnD_3rd", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I"], "type": "Domain"}, "IPR060737": {"description": "Uridylyltransferase GlnD, helical domain", "go_ids": [], "go_terms": [], "name": "GlnD_helical", "pathway_ids": ["PWY-7119", "PWY-6689", "PWY-6129", "PWY-7366", "PWY-5978"], "pathways": ["PWY-7119:t:ceramide and sphingolipid recycling and degradation (yeast)", "PWY-6689:t:tRNA splicing I", "PWY-6129:t:dolichol and dolichyl phosphate biosynthesis", "PWY-7366:t:phosphatidylglycerol degradation", "PWY-5978:t:kanosamine biosynthesis I"], "type": "Domain"}, "IPR060740": {"description": "TOF1-like, helical domain", "go_ids": [], "go_terms": [], "name": "TOF-1-like_helical", "pathway_ids": ["R-DME-432620", "R-DME-538898", "R-HSA-5693607", "R-DME-432553", "R-DME-432395", "R-RNO-5693607", "R-DME-432490", "R-DME-432501", "R-MMU-5693607"], "pathways": ["R-DME-432620:r:Dephosphorylation of PER", "R-DME-538898:r:Dephosphorylation of TIM", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-DME-432553:r:Phosphorylation of PER and TIM", "R-DME-432395:r:Degradation of TIM", "R-RNO-5693607:r:Processing of DNA double-strand break ends", "R-DME-432490:r:Nuclear import of PER and TIM", "R-DME-432501:r:Transcription repression by PER and activation by PDP1", "R-MMU-5693607:r:Processing of DNA double-strand break ends"], "type": "Domain"}, "IPR060741": {"description": "EFCAB4A/Rab-44, helical region", "go_ids": [], "go_terms": [], "name": "EFCAB4A/Rab-44_helical", "pathway_ids": ["R-MMU-6798695", "R-HSA-6798695", "R-HSA-8873719", "R-MMU-8873719"], "pathways": ["R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-8873719:r:RAB geranylgeranylation", "R-MMU-8873719:r:RAB geranylgeranylation"], "type": "Domain"}, "IPR060742": {"description": "MAP3K7-like, C-terminal coiled coil", "go_ids": [], "go_terms": [], "name": "MAPK37_C", "pathway_ids": ["R-HSA-9020702", "R-RNO-9020702", "R-HSA-168638", "R-HSA-937042", "R-BTA-5689880", "R-BTA-5357956", "R-BTA-202424", "R-HSA-9705671", "R-HSA-5689880", "R-RNO-937072", "R-MMU-450302", "R-MMU-5607764", "R-MMU-4086398", "R-MMU-9645460", "R-MMU-9020702", "R-MMU-937072", "R-RNO-450321", "R-MMU-5357956", "R-BTA-937072", "R-MMU-937042", "R-HSA-450321", "R-DME-450321", "R-BTA-450321", "R-BTA-2871837", "R-HSA-2871837", "R-MMU-5689880", "R-MMU-445989", "R-BTA-4086398", "R-RNO-9645460", "R-BTA-445989", "R-HSA-450302", "R-RNO-202424", "R-RNO-937042", "R-MMU-975163", "R-HSA-4086398", "R-MMU-168638", "R-BTA-168638", "R-HSA-937072", "R-HSA-5607764", "R-DME-4086398", "R-MMU-202424", "R-BTA-937042", "R-RNO-2871837", "R-RNO-975163", "R-HSA-445989", "R-MMU-450321", "R-HSA-975163", "R-DME-450302", "R-HSA-9645460", "R-RNO-5689880", "R-BTA-9645460", "R-RNO-4086398", "R-DME-445989", "R-HSA-1169091", "R-HSA-5357956", "R-RNO-5607764", "R-BTA-450302", "R-MMU-2871837", "R-BTA-9020702", "R-RNO-450302", "R-DME-209447", "R-HSA-9014325", "R-BTA-5607764", "R-RNO-5357956", "R-RNO-168638", "R-RNO-445989", "R-HSA-202424", "R-BTA-975163"], "pathways": ["R-HSA-9020702:r:Interleukin-1 signaling", "R-RNO-9020702:r:Interleukin-1 signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-202424:r:Downstream TCR signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-5607764:r:CLEC7A (Dectin-1) signaling", "R-MMU-4086398:r:Ca2+ pathway", "R-MMU-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-MMU-9020702:r:Interleukin-1 signaling", "R-MMU-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-RNO-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-MMU-937042:r:IRAK2 mediated activation of TAK1 complex", "R-HSA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-DME-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-MMU-5689880:r:Ub-specific processing proteases", "R-MMU-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-BTA-4086398:r:Ca2+ pathway", "R-RNO-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-RNO-202424:r:Downstream TCR signaling", "R-RNO-937042:r:IRAK2 mediated activation of TAK1 complex", "R-MMU-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-4086398:r:Ca2+ pathway", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-HSA-937072:r:TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-DME-4086398:r:Ca2+ pathway", "R-MMU-202424:r:Downstream TCR signaling", "R-BTA-937042:r:IRAK2 mediated activation of TAK1 complex", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-RNO-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-MMU-450321:r:JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "R-HSA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-DME-450302:r:activated TAK1 mediates p38 MAPK activation", "R-HSA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-5689880:r:Ub-specific processing proteases", "R-BTA-9645460:r:Alpha-protein kinase 1 signaling pathway", "R-RNO-4086398:r:Ca2+ pathway", "R-DME-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-450302:r:activated TAK1 mediates p38 MAPK activation", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-BTA-9020702:r:Interleukin-1 signaling", "R-RNO-450302:r:activated TAK1 mediates p38 MAPK activation", "R-DME-209447:r:Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY", "R-HSA-9014325:r:TICAM1,TRAF6-dependent induction of TAK1 complex", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-202424:r:Downstream TCR signaling", "R-BTA-975163:r:IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "type": "Domain"}, "IPR060743": {"description": "Spore coat protein Yuth-like", "go_ids": [], "go_terms": [], "name": "YutH-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060744": {"description": "Uncharacterized membrane protein YGR016W", "go_ids": [], "go_terms": [], "name": "YGR016W", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060745": {"description": "Uncharacterised conserved protein UCP012943", "go_ids": [], "go_terms": [], "name": "UCP012943", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060746": {"description": "Increased recombination centres protein 19", "go_ids": [], "go_terms": [], "name": "Irc19", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060747": {"description": "TraD, N-terminal", "go_ids": [], "go_terms": [], "name": "TraD_b_g-type_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060748": {"description": "Uncharacterised conserved protein UCP018868, prokaryotic", "go_ids": [], "go_terms": [], "name": "UCP018868_prok", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060749": {"description": "Uncharacterized protein AF_2401", "go_ids": [], "go_terms": [], "name": "AF_2401", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060750": {"description": "Tri6-like, C2H2 zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_Tri6-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060751": {"description": "Uncharacterised conserved protein UCP020893", "go_ids": [], "go_terms": [], "name": "UCP020893", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060752": {"description": "Membrane protein YqfB", "go_ids": [], "go_terms": [], "name": "YqfB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060753": {"description": "Uncharacterised conserved protein UCP022260", "go_ids": [], "go_terms": [], "name": "UCP022260", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060756": {"description": "Putative competence-induced protein Ccs4", "go_ids": [], "go_terms": [], "name": "Ccs4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060757": {"description": "UCP032817-like", "go_ids": [], "go_terms": [], "name": "UCP032817-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060758": {"description": "UCP032899-like", "go_ids": [], "go_terms": [], "name": "UCP032899-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060759": {"description": "UCP033725-like", "go_ids": [], "go_terms": [], "name": "UCP033725-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060760": {"description": "RNA-editing complex protein MP81-like, N-terminal domain", "go_ids": ["GO:0016556"], "go_terms": ["GO:0016556:mRNA modification:P"], "name": "MP81-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060761": {"description": "Mitochondrial translation factor Atp22", "go_ids": ["GO:0045182"], "go_terms": ["GO:0045182:translation regulator activity:F"], "name": "Atp22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060762": {"description": "Putative spore germination protein GerPD", "go_ids": ["GO:0009847"], "go_terms": ["GO:0009847:spore germination:P"], "name": "GerPD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060763": {"description": "Conserved hypothetical protein CHP03076-like", "go_ids": [], "go_terms": [], "name": "CHP03076-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060765": {"description": "Conserved hypothetical integral membrane protein", "go_ids": [], "go_terms": [], "name": "CHIM_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060766": {"description": "DNA sulphur modification system-associated protein 4-like", "go_ids": [], "go_terms": [], "name": "DNA_S_mod_dnd_assoc_4-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060767": {"description": "Cytochrome c lysine N-methyltransferase 1-like", "go_ids": ["GO:0008168"], "go_terms": ["GO:0008168:methyltransferase activity:F"], "name": "Ctm1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060768": {"description": "IBD2-like", "go_ids": ["GO:0007094"], "go_terms": ["GO:0007094:mitotic spindle assembly checkpoint signaling:P"], "name": "IBD2-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060769": {"description": "EIF3B-like, beta-propeller domain superfamily", "go_ids": [], "go_terms": [], "name": "EIF3B-like_beta-prop_sf", "pathway_ids": ["R-HSA-9013409", "R-MMU-72689", "R-SCE-204005", "R-RNO-9013149", "R-RNO-5610787", "R-HSA-156827", "R-RNO-72689", "R-MMU-72649", "R-HSA-72695", "R-BTA-72689", "R-RNO-72695", "R-MMU-72706", "R-DRE-5610787", "R-HSA-5610787", "R-MMU-5610787", "R-HSA-9013148", "R-BTA-72695", "R-RNO-9013406", "R-DME-5610787", "R-MMU-5620924", "R-MMU-72695", "R-BTA-156827", "R-MMU-72702", "R-HSA-5620924", "R-RNO-156827", "R-DDI-72695", "R-BTA-72702", "R-HSA-72706", "R-RNO-72702", "R-HSA-72689", "R-CEL-5620924", "R-HSA-72702", "R-HSA-72649", "R-MMU-156827", "R-RNO-72649", "R-HSA-9013149", "R-HSA-3214847", "R-HSA-9013406", "R-RNO-5620924", "R-BTA-72649", "R-HSA-9725370", "R-DDI-156827", "R-DDI-72702", "R-DDI-72689"], "pathways": ["R-HSA-9013409:r:RHOJ GTPase cycle", "R-MMU-72689:r:Formation of a pool of free 40S subunits", "R-SCE-204005:r:COPII-mediated vesicle transport", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-RNO-5610787:r:Hedgehog 'off' state", "R-HSA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72689:r:Formation of a pool of free 40S subunits", "R-MMU-72649:r:Translation initiation complex formation", "R-HSA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72689:r:Formation of a pool of free 40S subunits", "R-RNO-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-MMU-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-DRE-5610787:r:Hedgehog 'off' state", "R-HSA-5610787:r:Hedgehog 'off' state", "R-MMU-5610787:r:Hedgehog 'off' state", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-BTA-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-RNO-9013406:r:RHOQ GTPase cycle", "R-DME-5610787:r:Hedgehog 'off' state", "R-MMU-5620924:r:Intraflagellar transport", "R-MMU-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-MMU-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-5620924:r:Intraflagellar transport", "R-RNO-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72695:r:Formation of the ternary complex, and subsequently, the 43S complex", "R-BTA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72706:r:GTP hydrolysis and joining of the 60S ribosomal subunit", "R-RNO-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72689:r:Formation of a pool of free 40S subunits", "R-CEL-5620924:r:Intraflagellar transport", "R-HSA-72702:r:Ribosomal scanning and start codon recognition", "R-HSA-72649:r:Translation initiation complex formation", "R-MMU-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-RNO-72649:r:Translation initiation complex formation", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-RNO-5620924:r:Intraflagellar transport", "R-BTA-72649:r:Translation initiation complex formation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-DDI-156827:r:L13a-mediated translational silencing of Ceruloplasmin expression", "R-DDI-72702:r:Ribosomal scanning and start codon recognition", "R-DDI-72689:r:Formation of a pool of free 40S subunits"], "type": "Homologous_superfamily"}, "IPR060770": {"description": "MNIO-type RiPP peptide maturase HvfB-like", "go_ids": [], "go_terms": [], "name": "HvfB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060773": {"description": "SE2200 small protein", "go_ids": [], "go_terms": [], "name": "SE2200", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060778": {"description": "CT392", "go_ids": [], "go_terms": [], "name": "CT392", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060779": {"description": "RiPP cyclopeptide precursor peptide region", "go_ids": [], "go_terms": [], "name": "RiPP", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Conserved_site"}, "IPR060780": {"description": "ESX-1 associated ATP-binding protein EpsI, conserved site", "go_ids": [], "go_terms": [], "name": "EpsI_CS", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR060782": {"description": "Toxic protein TimP", "go_ids": [], "go_terms": [], "name": "TimP-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060786": {"description": "Magnetosome protein MamL, Rhodospirillales", "go_ids": [], "go_terms": [], "name": "MamL_Rhodospirillales", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060787": {"description": "Magnetosome protein MamJ", "go_ids": [], "go_terms": [], "name": "MamJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060788": {"description": "Type III secretion system early effector TepP", "go_ids": [], "go_terms": [], "name": "TepP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060796": {"description": "Transcriptional activator TdcR", "go_ids": [], "go_terms": [], "name": "TdcR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060798": {"description": "TraS", "go_ids": [], "go_terms": [], "name": "TraS", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060799": {"description": "YccE-like", "go_ids": [], "go_terms": [], "name": "YccE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060802": {"description": "DNA damage response protein C", "go_ids": [], "go_terms": [], "name": "DdrC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060810": {"description": "Uncharacterized protein YobI", "go_ids": [], "go_terms": [], "name": "YobI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060812": {"description": "Cell division inhibitor SidA", "go_ids": [], "go_terms": [], "name": "SidA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060814": {"description": "YadW", "go_ids": [], "go_terms": [], "name": "YadW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060816": {"description": "S-layer protein VapA", "go_ids": [], "go_terms": [], "name": "S-layer_VapA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060817": {"description": "Microcin J25", "go_ids": [], "go_terms": [], "name": "J25", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060818": {"description": "RP439", "go_ids": [], "go_terms": [], "name": "RP439", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060819": {"description": "Bacteriocin microcin B17", "go_ids": [], "go_terms": [], "name": "B17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060820": {"description": "YonT", "go_ids": [], "go_terms": [], "name": "YonT", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060821": {"description": "Cypemycin", "go_ids": [], "go_terms": [], "name": "Cypemycin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060822": {"description": "Bottromycin D", "go_ids": [], "go_terms": [], "name": "Bottromycin_D", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060823": {"description": "Trp operon leader peptide", "go_ids": [], "go_terms": [], "name": "Trp_leader", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060825": {"description": "Trifolitoxin", "go_ids": [], "go_terms": [], "name": "Trifolitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060826": {"description": "Precursor peptide TigB", "go_ids": [], "go_terms": [], "name": "TigB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060827": {"description": "Trp operon leader peptide, Corynebacterium", "go_ids": [], "go_terms": [], "name": "TrpL_Coryne", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060828": {"description": "SCO3933", "go_ids": [], "go_terms": [], "name": "SCO3933", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060829": {"description": "Aa3-type cytochrome oxidase subunit CtaJ", "go_ids": [], "go_terms": [], "name": "CtaJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060831": {"description": "PA4570", "go_ids": [], "go_terms": [], "name": "PA4570", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060832": {"description": "Gene transfer agent protein-like", "go_ids": [], "go_terms": [], "name": "Gene_transfer_agent", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060833": {"description": "Lipoprotein BTA121, duplicated domain", "go_ids": [], "go_terms": [], "name": "Lipo_BTA121_dup", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060835": {"description": "PPC1 domain", "go_ids": [], "go_terms": [], "name": "PPC1_domain", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060837": {"description": "Choice-of-anchor H domain", "go_ids": [], "go_terms": [], "name": "H_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060839": {"description": "Short putative RelE antitoxin", "go_ids": [], "go_terms": [], "name": "RelE_antitoxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060840": {"description": "PA0613", "go_ids": [], "go_terms": [], "name": "PA0613", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060841": {"description": "A1S_1983", "go_ids": [], "go_terms": [], "name": "A1S_1983", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060842": {"description": "BlhA", "go_ids": [], "go_terms": [], "name": "BlhA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060843": {"description": "Copper uptake system-associated domain", "go_ids": [], "go_terms": [], "name": "Copper_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060845": {"description": "RGCVC-like", "go_ids": [], "go_terms": [], "name": "RGCVC-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060846": {"description": "Streptamidine family RiPP", "go_ids": [], "go_terms": [], "name": "AmiA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060848": {"description": "SrpA", "go_ids": [], "go_terms": [], "name": "SrpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060849": {"description": "Alvin_2107", "go_ids": [], "go_terms": [], "name": "Alvin_2107", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060851": {"description": "Athe_2463 domain", "go_ids": [], "go_terms": [], "name": "Athe_2463_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060871": {"description": "Choice-of-anchor F", "go_ids": [], "go_terms": [], "name": "Choice_anch_F", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060886": {"description": "FAD-I protein", "go_ids": [], "go_terms": [], "name": "FAD_I", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060889": {"description": "RtxH", "go_ids": [], "go_terms": [], "name": "RtxH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060891": {"description": "MHO_1590, C-terminal", "go_ids": [], "go_terms": [], "name": "MHO_1590_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060894": {"description": "LB_137 protein", "go_ids": [], "go_terms": [], "name": "LB_137-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060895": {"description": "LA_1737 protein, C-terminal", "go_ids": [], "go_terms": [], "name": "LA_1737_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060897": {"description": "LIC_11321 protein", "go_ids": [], "go_terms": [], "name": "LIC_11321-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060900": {"description": "LIC_11695/LIC_11696 lipoprotein", "go_ids": [], "go_terms": [], "name": "LIC11695-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060901": {"description": "MAG1210-like", "go_ids": [], "go_terms": [], "name": "MAG1210-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060902": {"description": "Immunity protein BlpZ", "go_ids": [], "go_terms": [], "name": "BlpZ-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060905": {"description": "LOFI repeat", "go_ids": [], "go_terms": [], "name": "LoFi_rpt", "pathway_ids": [], "pathways": [], "type": "Repeat"}, "IPR060909": {"description": "MGA_1079 surface serine endopeptidase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MGA1079_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060910": {"description": "Exosortase-dependent surface domain 3 XDD3", "go_ids": [], "go_terms": [], "name": "XDD3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060911": {"description": "SAS053-like DNA gyrase inhibitor", "go_ids": [], "go_terms": [], "name": "SAS053_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060914": {"description": "Phage tail assembly chaperone GT, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Tail_chap_PVL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060916": {"description": "Dhp61 protein", "go_ids": [], "go_terms": [], "name": "Dhp61_prot", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060917": {"description": "Small membrane protein MtfM", "go_ids": [], "go_terms": [], "name": "MtfM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060918": {"description": "Exosortase-dependent surface protein XDP2", "go_ids": [], "go_terms": [], "name": "XDP2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060919": {"description": "KPN_01571 protein", "go_ids": [], "go_terms": [], "name": "KPN_01571-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060922": {"description": "HHHH-motif protein", "go_ids": [], "go_terms": [], "name": "HHHH-motif_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060924": {"description": "LIC_13346-like putative lipoprotein", "go_ids": [], "go_terms": [], "name": "LIC_13346-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060925": {"description": "KGW motif small protein", "go_ids": [], "go_terms": [], "name": "KGW_motif-containing", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060932": {"description": "Lmo1799-like Asp-Ala repeat surface protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Lmo1799-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060933": {"description": "Exosortase U, C-terminal region", "go_ids": [], "go_terms": [], "name": "XrtU_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060936": {"description": "SE1626-like", "go_ids": [], "go_terms": [], "name": "SE1626-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060937": {"description": "MyrrCad domain", "go_ids": [], "go_terms": [], "name": "Myrrcad_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060938": {"description": "Type IV secretion system effector BAB2_0123-like", "go_ids": [], "go_terms": [], "name": "T4SS_BAB2_0123-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060939": {"description": "Rv1678-like membrane protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Rv1678-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060941": {"description": "All3515-like Zur-repressed PEP-CTERM protein", "go_ids": [], "go_terms": [], "name": "All3515-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060947": {"description": "TRP47-like tandem repeat effector, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TRP47-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR060948": {"description": "LA_0991 family prenyltransferase-like", "go_ids": [], "go_terms": [], "name": "LA_0991-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR060950": {"description": "Mhp366/Mhp367-like surface (lipo)protein", "go_ids": [], "go_terms": [], "name": 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"IPR061332": {"description": "LA_2478/LA_2722/LA_4182-like", "go_ids": [], "go_terms": [], "name": "LA_2478_plus", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061334": {"description": "Putative pilus system protein FilA", "go_ids": [], "go_terms": [], "name": "Pilus_FilA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061335": {"description": "BREX-1 system phosphatase PglZ, type B", "go_ids": [], "go_terms": [], "name": "BREX_PglZ_1_B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061336": {"description": "Hormogonium tapered terminus morphoprotein TftA", "go_ids": [], "go_terms": [], "name": "Horm_taper_TftA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061337": {"description": "Phage exclusion lipoprotein Cor-like", "go_ids": [], "go_terms": [], "name": "Lamb_exclu_cor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061338": {"description": "Putative pilus system protein FilF", "go_ids": [], "go_terms": [], "name": "Pilus_FilF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061339": {"description": "LA_3696-like, N-terminal", "go_ids": [], "go_terms": [], "name": "LA_3696_Nterm", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061340": {"description": "LIC_13355-like lipoprotein", "go_ids": [], "go_terms": [], "name": "Lipo_LIC13355", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061341": {"description": "LA_3334-like", "go_ids": [], "go_terms": [], "name": "LA_3334_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061342": {"description": "NF038215-like lipoprotein", "go_ids": [], "go_terms": [], "name": "Acineto_lipo_PV", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061343": {"description": "Oligosaccharide repeat unit polymerase", "go_ids": [], "go_terms": [], "name": "Wzy_O6_O28", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061344": {"description": "Lipoprotein LipL41", "go_ids": [], "go_terms": [], "name": "Lipo_LipL41", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061345": {"description": "PhiSA1p31 domain", "go_ids": [], "go_terms": [], "name": "PhiSA1p31", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061346": {"description": "NF038120 family PEP-CTERM protein", "go_ids": [], "go_terms": [], "name": "PEP_CTERM_QFxxD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061347": {"description": "Mbov_0399 family ICE element protein", "go_ids": [], "go_terms": [], "name": "ICE_Mbov_0399", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061348": {"description": "NF038130 family PEP-CTERM protein", "go_ids": [], "go_terms": [], "name": "PEP_NF038130", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061349": {"description": "Cistern family PEP-CTERM protein", "go_ids": [], "go_terms": [], "name": "PEP-cistern", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061350": {"description": "GapS4b-like", "go_ids": [], "go_terms": [], "name": "Antiphage_GapS4b", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061351": {"description": "LIC_10494-like lipoprotein", "go_ids": [], "go_terms": [], "name": "Lipo_LIC10494", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061353": {"description": "MHFG family PEP-CTERM protein", "go_ids": [], "go_terms": [], "name": "PEP_CTERM_MHFG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061354": {"description": "Lipoprotein LipL21", "go_ids": [], "go_terms": [], "name": "Lipo_LipL21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061355": {"description": "Lipoprotein LipL46", "go_ids": [], "go_terms": [], "name": "Lipo_LipL46", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061356": {"description": "LIC11755 lipoprotein", "go_ids": [], "go_terms": [], "name": "Lipo_LIC11755", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061357": {"description": "Flagellar basal body rod modification protein", "go_ids": [], "go_terms": [], "name": "PRK12812.1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061358": {"description": "LIC11469 lipoprotein adhesin Lsa20", "go_ids": [], "go_terms": [], "name": "LIC11469_Lsa20", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061359": {"description": "LIC_10705 lipoprotein", "go_ids": [], "go_terms": [], "name": "Lipo_LIC_10705", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061360": {"description": "Bacteriophage spanin2 protein", "go_ids": [], "go_terms": [], "name": "Spanin2_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061361": {"description": "Exosortase Y-associated Wzy-like protein", "go_ids": [], "go_terms": [], "name": "XrtY_assoc_Wzy", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061362": {"description": "Ecr-like regulatory small membrane protein", "go_ids": [], "go_terms": [], "name": "Ecr-like_memb", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061363": {"description": "Myxosortase-dependent M36 metallopeptidase", "go_ids": [], "go_terms": [], "name": "Myxo_dep_M36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061364": {"description": "Antiviral RADAR system adenosine triphosphatase RdrA", "go_ids": [], "go_terms": [], "name": "RdrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061365": {"description": "Chryseobasin-related MNIO class RiPP peptide", "go_ids": [], "go_terms": [], "name": "ChrA-rel_RiPP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061368": {"description": "Scytonemin biosynthesis cyclase/decarboxylase ScyC", "go_ids": [], "go_terms": [], "name": "Scytonem_ScyC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061369": {"description": "BN159_2729 protein", "go_ids": [], "go_terms": [], "name": "BN159_2729-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061370": {"description": "Outer membrane exchange protein TraA", "go_ids": [], "go_terms": [], "name": "TraA_OM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061371": {"description": "MEMAR_RS02690 S-layer glycoprotein", "go_ids": [], "go_terms": [], "name": "S_layer_MEMAR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061372": {"description": "PavB adhesin, N-terminal", "go_ids": [], "go_terms": [], "name": "PavB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061374": {"description": "LEVG PEP-CTERM protein", "go_ids": [], "go_terms": [], "name": "PEP_CTERM_LEVG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061375": {"description": "Bgr_08870 protein, N-terminal", "go_ids": [], "go_terms": [], "name": "Bgr08870_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061376": {"description": "GapS6b protein", "go_ids": [], "go_terms": [], "name": "GapS6b-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061377": {"description": "Lipoprotein LipL36", "go_ids": [], "go_terms": [], "name": "LipL36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061378": {"description": "LA_3150 lipoprotein", "go_ids": [], "go_terms": [], "name": "LA_3150-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061379": {"description": "Adventurous gliding motility lipoprotein CglC", "go_ids": [], "go_terms": [], "name": "CglC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061380": {"description": "TRP75-like N-terminal", "go_ids": [], "go_terms": [], "name": "TRP75_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061381": {"description": "Adventurous gliding motility protein GltG", "go_ids": [], "go_terms": [], "name": "GltG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061382": {"description": "Adventurous gliding motility protein GltJ", "go_ids": [], "go_terms": [], "name": "GltJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061383": {"description": "BAR domain-like protein A BdpA", "go_ids": [], "go_terms": [], "name": "BdpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061384": {"description": "RadB lipoprotein", "go_ids": [], "go_terms": [], "name": "RadB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061385": {"description": "Rhombosortase-dependent M36 metallopeptidase", "go_ids": [], "go_terms": [], "name": "Rhom_dep_M36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061386": {"description": "Outer membrane exchange protein TraB", "go_ids": [], "go_terms": [], "name": "TraB_OM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061387": {"description": "Class 1 internalin InlK", "go_ids": [], "go_terms": [], "name": "InlK", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061388": {"description": "NGK_0946 protein", "go_ids": [], "go_terms": [], "name": "NGK_0946-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061389": {"description": "Collagen-binding adhesin Cnm", "go_ids": [], "go_terms": [], "name": "Cnm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061390": {"description": "von Willebrand factor binding protein Vwb", "go_ids": [], "go_terms": [], "name": "Vwb", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061391": {"description": "FTN_0109 protein", "go_ids": [], "go_terms": [], "name": "FTN_0109-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061392": {"description": "Pilin subunit UpsA", "go_ids": [], "go_terms": [], "name": "UpsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061393": {"description": "Outer membrane exchange accessory lipoprotein TraC", "go_ids": [], "go_terms": [], "name": "TraC_OM", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061394": {"description": "Pilin subunit UpsB", "go_ids": [], "go_terms": [], "name": "UpsB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061395": {"description": "DISARM system helicase DrmA, long form", "go_ids": [], "go_terms": [], "name": "DISARM_DrmAL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061396": {"description": "S-layer protein SlpA", "go_ids": [], "go_terms": [], "name": "SlpA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061397": {"description": "Francisella virulence factor A", "go_ids": [], "go_terms": [], "name": "FvfA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061398": {"description": "Cell-cell cohesion protein MtsD", "go_ids": [], "go_terms": [], "name": "MtsD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061399": {"description": "PTPDL protein", "go_ids": [], "go_terms": [], "name": "PTPDL-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061400": {"description": "LBF_0142 lipoprotein", "go_ids": [], "go_terms": [], "name": "LBF_0142-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061401": {"description": "Serine-rich aggregation substance UasX", "go_ids": [], "go_terms": [], "name": "Agg_sub_LPXTH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061402": {"description": "FTL_1293 small RNA FtrC-regulated protein", "go_ids": [], "go_terms": [], "name": "FTL_1293-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061403": {"description": "Dentilisin complex subunit PrcA", "go_ids": [], "go_terms": [], "name": "PrcA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061404": {"description": "Motility-associated protein Scm1", "go_ids": [], "go_terms": [], "name": "Scm1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061405": {"description": "Lp6.6 lipoprotein", "go_ids": [], "go_terms": [], "name": "Lipo_6_6", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061406": {"description": "CotZ-related putative spore coat protein", "go_ids": [], "go_terms": [], "name": "CotZ-rel", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061407": {"description": "CDI system lipoprotein BcpO", "go_ids": [], "go_terms": [], "name": "BcpO", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061408": {"description": "CNF1-like cytotoxic necrotizing factor", "go_ids": [], "go_terms": [], "name": "CNF1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061409": {"description": "LifA/Efa1-related large cytotoxin", "go_ids": [], "go_terms": [], "name": "LifA/Efa1-rel_toxin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061410": {"description": "T9SS-dependent outer membrane TapA/TapC-like", "go_ids": [], "go_terms": [], "name": "TapA/TapC-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061411": {"description": "NGO1622-like phage-associated putative holin", "go_ids": [], "go_terms": [], "name": "NGO1622-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061412": {"description": "MAG1680-like", "go_ids": [], "go_terms": [], "name": "MAG1680-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061413": {"description": "Anti-phage Hailong system nucleotidyltransferase HalB", "go_ids": [], "go_terms": [], "name": "Anti_phage_HalB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061415": {"description": "MyrrNad domain", "go_ids": [], "go_terms": [], "name": "Myrrnad_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061416": {"description": "Serine-rich glycoprotein adhesin, prefix domain", "go_ids": [], "go_terms": [], "name": "SerRich_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061417": {"description": "CDS14-like ICE transfer lipoprotein", "go_ids": [], "go_terms": [], "name": "ICE_LP_CDS14", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061419": {"description": "MAG1890-like", "go_ids": [], "go_terms": [], "name": "MAG1890-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061420": {"description": "Adhesion factor FAF", "go_ids": [], "go_terms": [], "name": "Adhesion_FAF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061421": {"description": "CFI-box putative sorting motif", "go_ids": [], "go_terms": [], "name": "Sort_motif_CFI", "pathway_ids": [], "pathways": [], "type": "Conserved_site"}, "IPR061422": {"description": "Collagen-binding adhesin autotransporter EmaA", "go_ids": [], "go_terms": [], "name": "EmaA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061423": {"description": "GEGP motif-containing diheme protein", "go_ids": [], "go_terms": [], "name": "Diheme_GEGP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061424": {"description": "Autotransporter adhesin RadD", "go_ids": [], "go_terms": [], "name": "RadD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061425": {"description": "AMEP412-like elicitor-associated permease-like", "go_ids": [], "go_terms": [], "name": "Elici_assc_perm", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061426": {"description": "TrhA, N-terminal extension domain", "go_ids": [], "go_terms": [], "name": "TrhA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061427": {"description": "Myxosortase MrtZ", "go_ids": [], "go_terms": [], "name": "MrtZ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061428": {"description": "EtpE-like", "go_ids": [], "go_terms": [], "name": "EtpE-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061429": {"description": "EspK/GogB-like type III secretion system effector", "go_ids": [], "go_terms": [], "name": "EspK/GogB-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061431": {"description": "Exosortase W", "go_ids": [], "go_terms": [], "name": "XrtW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061432": {"description": "Trimeric autotransporter actin-nucleating factor BimA", "go_ids": [], "go_terms": [], "name": "BimA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061433": {"description": "Transglutaminase-like, putative", "go_ids": [], "go_terms": [], "name": "Transglutaminase-like_put", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061435": {"description": "Colicin Z toxin", "go_ids": [], "go_terms": [], "name": "Colicin_Z", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061436": {"description": "PLuB system helicase-like", "go_ids": [], "go_terms": [], "name": "PLuB_helicase-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061437": {"description": "Type III-I CRISPR-associated gRAMP effector Cas7-11i", "go_ids": [], "go_terms": [], "name": "Cas_III-I_gRAMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061438": {"description": "Type III-E CRISPR-associated protein Csx30", "go_ids": [], "go_terms": [], "name": "CAS_csx30", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061440": {"description": "Type III-E CRISPR-associated TPR-CHAT protein Csx29", "go_ids": [], "go_terms": [], "name": "CAS_csx29_CRASP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061441": {"description": "Type III-E CRISPR-associated gRAMP effector Cas7-11e", "go_ids": [], "go_terms": [], "name": "Cas_III-E_gRAMP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061442": {"description": "Metal-binding double selenoprotein MbdU-like", "go_ids": [], "go_terms": [], "name": "2X_seleno_MbdU-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061443": {"description": "Exosortase XrtG-like, N-terminal extension domain", "go_ids": [], "go_terms": [], "name": "XrtG_Nterm_ext", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061445": {"description": "Triculamin-like lasso peptide precursor", "go_ids": [], "go_terms": [], "name": "Triculamin_precursor", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061450": {"description": "MFS transporter auxiliary subunit, OFA tail-like domain", "go_ids": [], "go_terms": [], "name": "MFS_OXA_tail_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061451": {"description": "Major curlin subunit, enterobacterales", "go_ids": [], "go_terms": [], "name": "CsgA_enterobact", 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"go_terms": [], "name": "Herpes_Pol_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061943": {"description": "AIM39, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AIM39_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061944": {"description": "UPF0507, helical domain", "go_ids": [], "go_terms": [], "name": "UPF0507_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061945": {"description": "Altered inheritance of mitochondria protein 44", "go_ids": [], "go_terms": [], "name": "AIM44", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061946": {"description": "RRG1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RRG1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061947": {"description": "ATPase expression protein 2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AEP2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061948": {"description": "Trypacidin cluster transcriptional coactivator tpcD-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TpcD-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061949": {"description": "Serine rich endogenous peptide 16-like", "go_ids": [], "go_terms": [], "name": "PROSCOOP16-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061950": {"description": "RMD9, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RMD9_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061951": {"description": "Topoisomerase I damage affected protein 7 domain", "go_ids": [], "go_terms": [], "name": "TDA7_beta-sheet", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061952": {"description": "Arrestin-related trafficking adapter 10, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ART10_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061953": {"description": "MICOS complex subunit MIC27", "go_ids": [], "go_terms": [], "name": "MIC27", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061954": {"description": "Mediator complex subunit 17, middle domain", "go_ids": [], "go_terms": [], "name": "Med17_M", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-BTA-9841922", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR061955": {"description": "Lactoperoxidase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LPO_N", "pathway_ids": ["PWY-5466", "PWY-6824", "PWY-5461", "PWY-7445", "PWY-8249", "PWY-7214", "PWY-5469", "R-HSA-8941413", "R-HSA-6798695", "R-MMU-8941413", "R-MMU-6798695", "R-SSC-6798695", "R-BTA-8941413"], "pathways": ["PWY-5466:t:matairesinol biosynthesis", "PWY-6824:t:justicidin B biosynthesis", "PWY-5461:t:betanidin degradation", "PWY-7445:t:luteolin triglucuronide degradation", "PWY-8249:t:xanthommatin biosynthesis", "PWY-7214:t:baicalein degradation (hydrogen peroxide detoxification)", "PWY-5469:t:sesamin biosynthesis", "R-HSA-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-HSA-6798695:r:Neutrophil degranulation", "R-MMU-8941413:r:Events associated with phagocytolytic activity of PMN cells", "R-MMU-6798695:r:Neutrophil degranulation", "R-SSC-6798695:r:Neutrophil degranulation", "R-BTA-8941413:r:Events associated with phagocytolytic activity of PMN cells"], "type": "Domain"}, "IPR061956": {"description": "Maintenance of telomere capping protein 2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "MTC2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061957": {"description": "Outer spore wall assembly protein SHE10, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SHE10_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061958": {"description": "Effector protein BopA , C-terminal domain", "go_ids": [], "go_terms": [], "name": "BopA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061959": {"description": "FNDC3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FNDC3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061960": {"description": "ATAD2 ATPase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ATAD2_C", "pathway_ids": ["R-HSA-8866910", "R-MMU-8866910"], "pathways": ["R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-MMU-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "type": "Domain"}, "IPR061961": {"description": "tRNA-specific adenosine deaminase TAD3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TAD3_N", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR061962": {"description": "Arginine-containing cyclodipeptide synthase", "go_ids": [], "go_terms": [], "name": "ANKA-like", "pathway_ids": ["PWY-7612", "PWY-7650", "PWY-6574", "PWY-7549", "PWY-7673", "PWY-7989", "PWY-7533", "PWY-7665", "PWY-6289", "PWY-7670", "PWY-7842", "PWY-7571", "PWY-7735", "PWY-7563", "PWY-7577", "PWY-7600", "PWY-6378", "PWY-7660", "PWY-7555", "PWY-7770", "PWY-8012", "PWY-6379", "PWY-7988", "PWY-7954", "PWY-7543", "PWY-6374", "PWY-7737", "PWY-7556", "PWY-7569", "PWY-7510", "PWY-7561", "PWY-7690", "PWY-761", "PWY-7797", "PWY-6409", "PWY-7570", "PWY-7605", "PWY-7668", "PWY-7542", "PWY-7667", "PWY-7565"], "pathways": ["PWY-7612:t:chaetoglobosin A biosynthesis", "PWY-7650:t:echinocandin B biosynthesis", "PWY-6574:t:achromobactin biosynthesis", "PWY-7549:t:asperlicin E biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7989:t:acinetoferrin biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7665:t:aureobasidin A biosynthesis", "PWY-6289:t:petrobactin biosynthesis", "PWY-7670:t:fusaridione A biosynthesis", "PWY-7842:t:UDP-yelosamine biosynthesis", "PWY-7571:t:ferrichrome A biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-7563:t:bassianin and desmethylbassianin biosynthesis", "PWY-7577:t:ferrichrome biosynthesis", "PWY-7600:t:peramine biosynthesis", "PWY-6378:t:putrebactin biosynthesis", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-7555:t:alpha-cyclopiazonate biosynthesis", "PWY-7770:t:indolmycin biosynthesis", "PWY-8012:t:mupirocin biosynthesis", "PWY-6379:t:alcaligin biosynthesis", "PWY-7988:t:baumannoferrin biosynthesis", "PWY-7954:t:tabtoxinine-beta-lactam biosynthesis", "PWY-7543:t:5-N-acetylardeemin biosynthesis", "PWY-6374:t:vibriobactin biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-7556:t:(-)-microperfuranone biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7510:t:rhizocticin A and B biosynthesis", "PWY-7561:t:tenellin biosynthesis", "PWY-7690:t:holomycin biosynthesis", "PWY-761:t:rhizobactin 1021 biosynthesis", "PWY-7797:t:nocardicin A biosynthesis", "PWY-6409:t:pyoverdine I biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7605:t:roquefortine C biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7542:t:fumiquinazoline D biosynthesis", "PWY-7667:t:apicidin biosynthesis", "PWY-7565:t:aspyridone A biosynthesis"], "type": "Family"}, "IPR061963": {"description": "Chloroplast protein ycf73", "go_ids": [], "go_terms": [], "name": "Ycf73", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061964": {"description": "UPF0508, PH domain", "go_ids": [], "go_terms": [], "name": "UPF0508_PH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061965": {"description": "UPF0508, N-terminal domain", "go_ids": [], "go_terms": [], "name": "UPF0508_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061966": {"description": "AT-rich binding protein, N-terminal C2H2-type zinc finger domain", "go_ids": [], "go_terms": [], "name": "Zf-C2H2_ATbp_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061967": {"description": "Teflon, middle domain", "go_ids": [], "go_terms": [], "name": "Teflon_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061968": {"description": "AF_2183-like", "go_ids": [], "go_terms": [], "name": "AF_2183-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061969": {"description": "PQBP1, helical domain", "go_ids": [], "go_terms": [], "name": "PQBP1_helical", "pathway_ids": ["R-HSA-72163", "R-RNO-72163", "R-HSA-9918481", "R-MMU-72163", "R-BTA-72163"], "pathways": ["R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-HSA-9918481:r:Dengue Virus-Host Interactions", "R-MMU-72163:r:mRNA Splicing - Major Pathway", "R-BTA-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR061970": {"description": "TIM14, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TIM14_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061971": {"description": "Spore membrane assembly protein 2", "go_ids": [], "go_terms": [], "name": "SMA2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061972": {"description": "Serine rich endogenous peptide", "go_ids": [], "go_terms": [], "name": "SCOOP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061973": {"description": "Serine rich endogenous peptide 22", "go_ids": [], "go_terms": [], "name": "PROSCOOP22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061974": {"description": "Autophagy-related protein 23", "go_ids": [], "go_terms": [], "name": "ATG23", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061975": {"description": "Salivary glue protein", "go_ids": [], "go_terms": [], "name": "Salivary_glue", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061976": {"description": "TcsH, C-terminal DRBD", "go_ids": [], "go_terms": [], "name": "DRBD_TcsH_C", "pathway_ids": ["PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697", "PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209"], "pathways": ["PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis", "PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis"], "type": "Domain"}, "IPR061978": {"description": "TBC1D1/TBC1D4, helical domain", "go_ids": [], "go_terms": [], "name": "TBC1D_hel", "pathway_ids": ["R-HSA-1445148"], "pathways": ["R-HSA-1445148:r:Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "type": "Domain"}, "IPR061979": {"description": "CYLD, SH3 domain", "go_ids": [], "go_terms": [], "name": "SH3_CYLD", "pathway_ids": ["R-MMU-5357786", "R-HSA-168638", "R-BTA-5357956", "R-BTA-5689880", "R-BTA-5357786", "R-HSA-5689880", "R-RNO-5357905", "R-HSA-936440", "R-MMU-5357956", "R-HSA-5357786", "R-RNO-5689880", "R-MMU-5689880", "R-HSA-5357905", "R-BTA-936440", "R-HSA-5357956", "R-RNO-936440", "R-MMU-5357905", "R-RNO-5357956", "R-RNO-168638", "R-MMU-936440", "R-MMU-168638", "R-RNO-5357786", "R-BTA-168638", "R-BTA-5357905"], "pathways": ["R-MMU-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5689880:r:Ub-specific processing proteases", "R-BTA-5357786:r:TNFR1-induced proapoptotic signaling", "R-HSA-5689880:r:Ub-specific processing proteases", "R-RNO-5357905:r:Regulation of TNFR1 signaling", "R-HSA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5357786:r:TNFR1-induced proapoptotic signaling", "R-RNO-5689880:r:Ub-specific processing proteases", "R-MMU-5689880:r:Ub-specific processing proteases", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-BTA-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-168638:r:NOD1/2 Signaling Pathway", "R-MMU-936440:r:Negative regulators of DDX58/IFIH1 signaling", "R-MMU-168638:r:NOD1/2 Signaling Pathway", "R-RNO-5357786:r:TNFR1-induced proapoptotic signaling", "R-BTA-168638:r:NOD1/2 Signaling Pathway", "R-BTA-5357905:r:Regulation of TNFR1 signaling"], "type": "Domain"}, "IPR061980": {"description": "ORANGE-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Orange-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061981": {"description": "GtfB, third domain", "go_ids": [], "go_terms": [], "name": "GtfB_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061982": {"description": "GtfB, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GtfB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061983": {"description": "Nociceptin neuropeptide 2", "go_ids": [], "go_terms": [], "name": "Nociceptin_2", "pathway_ids": ["R-HSA-418594", "R-BTA-418594", "R-RNO-375276", "R-HSA-375276", "R-MMU-375276", "R-MMU-418594", "R-BTA-375276", "R-RNO-418594"], "pathways": ["R-HSA-418594:r:G alpha (i) signalling events", "R-BTA-418594:r:G alpha (i) signalling events", "R-RNO-375276:r:Peptide ligand-binding receptors", "R-HSA-375276:r:Peptide ligand-binding receptors", "R-MMU-375276:r:Peptide ligand-binding receptors", "R-MMU-418594:r:G alpha (i) signalling events", "R-BTA-375276:r:Peptide ligand-binding receptors", "R-RNO-418594:r:G alpha (i) signalling events"], "type": "Family"}, "IPR061984": {"description": "LRC39, N-terminal domin", "go_ids": [], "go_terms": [], "name": "LRC39_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061985": {"description": "Outer membrane usher protein EcpC, N-terminal domain", "go_ids": [], "go_terms": [], "name": "EcpC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061986": {"description": "Fimbria adhesin EcpD, middle domain", "go_ids": [], "go_terms": [], "name": "EcpD_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061987": {"description": "Fimbria adhesin EcpD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "EcpD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061988": {"description": "DMAC2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DMAC2_N", "pathway_ids": ["R-BTA-6799198", "R-MMU-6799198", "R-HSA-6799198", "R-RNO-6799198"], "pathways": ["R-BTA-6799198:r:Complex I biogenesis", "R-MMU-6799198:r:Complex I biogenesis", "R-HSA-6799198:r:Complex I biogenesis", "R-RNO-6799198:r:Complex I biogenesis"], "type": "Domain"}, "IPR061989": {"description": "SIFamide-related peptide", "go_ids": [], "go_terms": [], "name": "SIFAMIDE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061990": {"description": "Alpha-ionylideneethane synthase aba3", "go_ids": [], "go_terms": [], "name": "Aba3", "pathway_ids": ["PWY-6254", "PWY-6653", "PWY-6160", "PWY-5725", "PWY-5197", "PWY-5414", "PWY-7721", "PWY-3041", "PWY-6275", "PWY-6257", "PWY-6258"], "pathways": ["PWY-6254:t:santalene biosynthesis I", "PWY-6653:t:ent -kaurene biosynthesis II", "PWY-6160:t:3-dehydroquinate biosynthesis II (archaea)", "PWY-5725:t:farnesene biosynthesis", "PWY-5197:t:lactate biosynthesis (archaea)", "PWY-5414:t:palustric acid biosynthesis", "PWY-7721:t:methyl phomopsenoate biosynthesis", "PWY-3041:t:monoterpene biosynthesis", "PWY-6275:t:beta-caryophyllene biosynthesis", "PWY-6257:t:curcumene biosynthesis", "PWY-6258:t:patchoulol biosynthesis"], "type": "Family"}, "IPR061991": {"description": "Allatostatin, insecta", "go_ids": [], "go_terms": [], "name": "Ast_insect", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR061992": {"description": "AMN1, small helical domain", "go_ids": [], "go_terms": [], "name": "AMN1_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061993": {"description": "RIM13, second calpain-like domain", "go_ids": [], "go_terms": [], "name": "RIM13_calpain-like_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061994": {"description": "RIM13, C-terminal", "go_ids": [], "go_terms": [], "name": "RIM13_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061995": {"description": "YPP1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YPP1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061996": {"description": "IHD1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "IHD1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061997": {"description": "Transposon Ty4, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Ty4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061998": {"description": "Transposon Ty4, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Ty4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR061999": {"description": "Cadherin-23, alpha/beta domain", "go_ids": [], "go_terms": [], "name": "CDH23_a-b", "pathway_ids": ["R-HSA-9662360", "R-DME-114608", "R-DME-8980692", "R-HSA-9662361"], "pathways": ["R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-DME-114608:r:Platelet degranulation", "R-DME-8980692:r:RHOA GTPase cycle", "R-HSA-9662361:r:Sensory processing of sound by outer hair cells of the cochlea"], "type": "Domain"}, "IPR062000": {"description": "Phage replication protein O, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Phage_rep_O_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062001": {"description": "Cellulose synthase catalytic subunit, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BcsA_N", "pathway_ids": ["PWY-1001", "R-HSA-9931953"], "pathways": ["PWY-1001:t:cellulose biosynthesis", "R-HSA-9931953:r:Biofilm formation"], "type": "Domain"}, "IPR062002": {"description": "Inner membrane protein YabI-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YabI-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062003": {"description": "TIGD5, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TIGD5_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062004": {"description": "Alpha-2-macroglobulin, Ig-like domain 1", "go_ids": [], "go_terms": [], "name": "A2M_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062005": {"description": "CST complex subunit CTC1, sixth domain", "go_ids": [], "go_terms": [], "name": "CTC1_6th", "pathway_ids": ["R-MMU-174430", "R-DRE-174430", "R-MMU-174411", "R-HSA-174411", "R-HSA-174430"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174430:r:Telomere C-strand synthesis initiation"], "type": "Domain"}, "IPR062006": {"description": "RxLR effector protein CRE9", "go_ids": [], "go_terms": [], "name": "CRE9", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062007": {"description": "PEPCK-like, middle domain", "go_ids": [], "go_terms": [], "name": "PEPCK-like_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062008": {"description": "PPi-type PEPCK, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PEPCK_PPi_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062009": {"description": "PPi-PEPCK, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PPi_PEPCK_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062010": {"description": "Y3IP1/CEST, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Y3IP1_CEST_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062011": {"description": "DIA1", "go_ids": [], "go_terms": [], "name": "DIA1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062012": {"description": "Accessory colonization factor AcfD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AcfD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062013": {"description": "Accessory colonization factor AcfD, fourth domain", "go_ids": [], "go_terms": [], "name": "AcfD_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062014": {"description": "Myosuppressin", "go_ids": [], "go_terms": [], "name": "Myosuppressin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062015": {"description": "Uncharacterised protein ML2630", "go_ids": [], "go_terms": [], "name": "ML2630", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062016": {"description": "Countin, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Countin_C", "pathway_ids": ["R-DDI-6798695", "R-DDI-8964038"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-8964038:r:LDL clearance"], "type": "Domain"}, "IPR062018": {"description": "Transmembrane protein 81, transmembrane region", "go_ids": [], "go_terms": [], "name": "TMEM81_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062019": {"description": "Uroplakin-3b-like protein 1/2, transmembrane region", "go_ids": [], "go_terms": [], "name": "UPK3L_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062020": {"description": "UPF0540 protein At1g62060-like, beta-sheet domain", "go_ids": [], "go_terms": [], "name": "UPF0540_At1g62060_beta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062021": {"description": "Meiotic sister-chromatid recombination protein 3, beta-sheet domain", "go_ids": [], "go_terms": [], "name": "MSC3_beta", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062022": {"description": "HrmA-C, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HrmA-C_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062023": {"description": "Mediator of RNA polymerase II, transcription subunit 1.1/1.2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Mdt-12_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062024": {"description": "GEP7, C-terminal", "go_ids": [], "go_terms": [], "name": "GEP7_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062026": {"description": "Embryonic testis differentiation protein", "go_ids": [], "go_terms": [], "name": "ETD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062027": {"description": "Lebocin-like anionic peptide 1-like", "go_ids": [], "go_terms": [], "name": "LEB1-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062028": {"description": "Defensin-like DF298, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DF298_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062029": {"description": "REX3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "REX3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062030": {"description": "DEF265-like, conserved domain", "go_ids": [], "go_terms": [], "name": "DEF265", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062031": {"description": "MSC6, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MSC6_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062032": {"description": "Transcriptional activator POG1, N-terminal", "go_ids": [], "go_terms": [], "name": "POG1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062033": {"description": "ABM1-like1", "go_ids": [], "go_terms": [], "name": "ABM1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062034": {"description": "YKR005C-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YKR005C_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062035": {"description": "P granule abnormality protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PGL_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062036": {"description": "P granule abnormality protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PGL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062037": {"description": "Uncharacterized protein YLR157C-C", "go_ids": [], "go_terms": [], "name": "YLR157C-C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062038": {"description": "YiaV/YibH, N-terminal transmembrane domain", "go_ids": [], "go_terms": [], "name": "YiaV_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062039": {"description": "Corrinoid adenosyltransferase EutT, N-terminal domain", "go_ids": [], "go_terms": [], "name": "EutT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062040": {"description": "Apolipoprotein B100, insert 6", "go_ids": [], "go_terms": [], "name": "ApoB100_6ins", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-HSA-8964038", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-RNO-5686938", "R-MMU-3000471", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-HSA-8957275", "R-RNO-3000480", "R-HSA-202733", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964038:r:LDL clearance", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR062041": {"description": "Apolipoprotein B100, insert 8", "go_ids": [], "go_terms": [], "name": "ApoB100_8ins", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-HSA-8964038", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-RNO-5686938", "R-MMU-3000471", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-HSA-8957275", "R-RNO-3000480", "R-HSA-202733", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964038:r:LDL clearance", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR062042": {"description": "COASY, N-terminal domain", "go_ids": [], "go_terms": [], "name": "COASY_N", "pathway_ids": ["PWY-7851", "PWY-8342", "R-MMU-196783", "R-HSA-196783"], "pathways": ["PWY-7851:t:coenzyme A biosynthesis II (eukaryotic)", "PWY-8342:t:coenzyme A biosynthesis III (archaea)", "R-MMU-196783:r:Coenzyme A biosynthesis", "R-HSA-196783:r:Coenzyme A biosynthesis"], "type": "Domain"}, "IPR062043": {"description": "STR4-like, C-terminal region", "go_ids": [], "go_terms": [], "name": "STR4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062044": {"description": "ITPK4, N-terminal HAD-like domain", "go_ids": [], "go_terms": [], "name": "HAD_ITPK4_N", "pathway_ids": ["PWY-6366", "PWY-6554", "PWY-6362", "PWY-6372", "PWY-6365"], "pathways": ["PWY-6366:t:D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis", "PWY-6554:t:1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)", "PWY-6362:t:1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)", "PWY-6372:t:1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)", "PWY-6365:t:D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis"], "type": "Domain"}, "IPR062045": {"description": "Halfway, C-terminal helix", "go_ids": [], "go_terms": [], "name": "Halfway_C", "pathway_ids": ["R-DME-388844"], "pathways": ["R-DME-388844:r:Receptor-type tyrosine-protein phosphatases"], "type": "Domain"}, "IPR062046": {"description": "FAD synthetase 1/2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RIBF1-2_C", "pathway_ids": ["PWY-6168", "PWY-6167"], "pathways": ["PWY-6168:t:flavin biosynthesis III (fungi)", "PWY-6167:t:flavin biosynthesis II (archaea)"], "type": "Domain"}, "IPR062047": {"description": "DGAT3, N-terminal", "go_ids": [], "go_terms": [], "name": "DGAT3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062048": {"description": "NblS/DspA histidine kinase, PAS-like sensory domain", "go_ids": [], "go_terms": [], "name": "PAS_NblS", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062049": {"description": "Toxin SpoIISA, transmembrane domain", "go_ids": [], "go_terms": [], "name": "SpoIISA_transm", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062050": {"description": "Prohormone-3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Prohormone3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062051": {"description": "Gem-associated protein 4, first TPR domain", "go_ids": [], "go_terms": [], "name": "Gem4_TPR_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062052": {"description": "Prohormone-3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Prohormone3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062053": {"description": "CD19, transmembrane domain", "go_ids": [], "go_terms": [], "name": "CD19_TM", "pathway_ids": ["R-MMU-198933", "R-MMU-977606", "R-HSA-977606", "R-HSA-983695", "R-MMU-6811558", "R-HSA-198933", "R-HSA-2219530", "R-HSA-1257604", "R-MMU-1257604", "R-MMU-983695", "R-HSA-6811558"], "pathways": ["R-MMU-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-MMU-977606:r:Regulation of Complement cascade", "R-HSA-977606:r:Regulation of Complement cascade", "R-HSA-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-198933:r:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-MMU-983695:r:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "type": "Domain"}, "IPR062054": {"description": "Poxvirus A26L envelope protein, middle domain", "go_ids": [], "go_terms": [], "name": "Pox_A26L_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062055": {"description": "Succinate dehydrogenase subunit 8, mitochondrial", "go_ids": [], "go_terms": [], "name": "SDH8", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062056": {"description": "RNF186, helical domain", "go_ids": [], "go_terms": [], "name": "RNF186_helical", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR062057": {"description": "Secreted virulence factor MC69", "go_ids": [], "go_terms": [], "name": "MC69", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062058": {"description": "RNF183, C-terminal transmembrane domain", "go_ids": [], "go_terms": [], "name": "RNF183_C", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR062059": {"description": "Defensin 207-like, defensin domain", "go_ids": [], "go_terms": [], "name": "Defensin_DF207", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062060": {"description": "Defensin 258-like, C-terminal", "go_ids": [], "go_terms": [], "name": "DEF258-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062061": {"description": "Gem-associated protein 4, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Gem4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062062": {"description": "YOL036W-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YOL036W_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062063": {"description": "Gas vesicle protein I", "go_ids": [], "go_terms": [], "name": "GvpI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062064": {"description": "SP85-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SP85_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062066": {"description": "IGSF6, transmembrane helix", "go_ids": [], "go_terms": [], "name": "IGSF6_TM", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062068": {"description": "YJL043W-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YJL043W_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062069": {"description": "Regulator of Ty1 transposition protein 105-like, conserved region", "go_ids": [], "go_terms": [], "name": "RTT105", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062070": {"description": "Merozoite surface protein 9, helical domain", "go_ids": [], "go_terms": [], "name": "Merozoite_surf_9_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062071": {"description": "Cpxcr1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Cpxcr1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062072": {"description": "Defensin-like protein 293", "go_ids": [], "go_terms": [], "name": "DEF293", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR062073": {"description": "YPR027C", "go_ids": [], "go_terms": [], "name": "YPR027C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR062074": {"description": "Protein three rows, C-terminal domain", "go_ids": [], "go_terms": [], "name": "THR_C", "pathway_ids": [], "pathways": [], 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biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR063061": {"description": "DNA helicase IV HelD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HelD_N", "pathway_ids": ["PWY-7250"], "pathways": ["PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis"], "type": "Domain"}, "IPR063062": {"description": "Eukaryotic translation initiation factor 2A C-terminal domain", "go_ids": [], "go_terms": [], "name": "EIF2A_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063063": {"description": "RBR-type E3 ubiquitin ligase RNF19, helical hairpin domain", "go_ids": [], "go_terms": [], "name": "RBR_HH", "pathway_ids": ["R-HSA-983168", "R-SSC-983168", "R-MMU-983168", "R-DRE-983168"], "pathways": ["R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SSC-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR063064": {"description": "YehL-like AAA+ ATPase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YehL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063065": {"description": "KMS1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "KMS1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063066": {"description": "AziU2-like, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "AziU2-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063067": {"description": "Transfer protein TraSA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TraSA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063068": {"description": "AbeC-like domain", "go_ids": [], "go_terms": [], "name": "AbeC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063069": {"description": "Metallophosphoesterase YhaO, middle domain", "go_ids": [], "go_terms": [], "name": "YhaO_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063070": {"description": "ORF2p, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ORF2p_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063071": {"description": "Uncharacterized protein aq_1923", "go_ids": [], "go_terms": [], "name": "Aq_1923", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063072": {"description": "HrpA, N-terminal alpha-helical hairpin binding domain", "go_ids": [], "go_terms": [], "name": "APHB_HrpA", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063073": {"description": "Mitochondrial helicase Irc3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Irc3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063074": {"description": "YibE/F, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YibE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063075": {"description": "Maltose operon periplasmic protein MalM, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MalM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063076": {"description": "Uncharacterised protein Rv0250c", "go_ids": [], "go_terms": [], "name": "Rv0250c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063077": {"description": "Hybrid histidine kinase-response regulator, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HK_RR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063078": {"description": "UPF0606 protein KIAA1549, alpha/beta domain 1", "go_ids": [], "go_terms": [], "name": "KIAA1549_1st", "pathway_ids": ["R-HSA-6802952"], "pathways": ["R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR063079": {"description": "AA11 lytic polysaccharide monooxygenase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LPMO11_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063080": {"description": "Iron-sulfur cluster protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FeS_hyd_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063081": {"description": "SpoVK-like AAA ATPase, second domain", "go_ids": [], "go_terms": [], "name": "AAA_SpoVK_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063082": {"description": "DUF5686, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DUF5686_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063083": {"description": "GspL, transmembrane domain", "go_ids": [], "go_terms": [], "name": "GspL_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063084": {"description": "WYL domain-containing protein, N-terminal winged helix domain", "go_ids": [], "go_terms": [], "name": "WHD_WYL_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063085": {"description": "Type II secretion system (T2SS) protein M, transmembrane region", "go_ids": [], "go_terms": [], "name": "T2SSM_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063086": {"description": "IML1, small domain", "go_ids": [], "go_terms": [], "name": "IML1_small", "pathway_ids": ["R-MMU-9639288", "R-HSA-9639288", "R-DDI-9639288"], "pathways": ["R-MMU-9639288:r:Amino acids regulate mTORC1", "R-HSA-9639288:r:Amino acids regulate mTORC1", "R-DDI-9639288:r:Amino acids regulate mTORC1"], "type": "Domain"}, "IPR063087": {"description": "TRAPPC10, first Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TRAPPC10_1st", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-HSA-8876198", "R-MMU-8876198", "R-DME-8876198", "R-DME-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DME-204005:r:COPII-mediated vesicle transport"], "type": "Domain"}, "IPR063088": {"description": "TraB family protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TraB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063089": {"description": "Zu5-like domain", "go_ids": [], "go_terms": [], "name": "Zu5-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063090": {"description": "Signal peptidase SEC11, C-terminal short helix", "go_ids": [], "go_terms": [], "name": "SPase_CTS", "pathway_ids": ["R-HSA-1799339", "R-HSA-9918432", "R-CFA-422085", "R-HSA-422085", "R-RNO-9768727", "R-MMU-422085", "R-BTA-422085", "R-CFA-9768727", "R-HSA-9828806", "R-BTA-9768727", "R-RNO-422085", "R-HSA-381771", "R-HSA-9768727", "R-MMU-9768727", "R-HSA-400511"], "pathways": ["R-HSA-1799339:r:SRP-dependent cotranslational protein targeting to membrane", "R-HSA-9918432:r:Maturation of DENV proteins", "R-CFA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-RNO-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-BTA-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-CFA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-9828806:r:Maturation of hRSV A proteins", "R-BTA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-RNO-422085:r:Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-381771:r:Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-MMU-9768727:r:Regulation of CDH1 posttranslational processing and trafficking to plasma membrane", "R-HSA-400511:r:Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "type": "Domain"}, "IPR063091": {"description": "AICE RepA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AICE_RepA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063092": {"description": "Rabenosyn-5, middle domain", "go_ids": [], "go_terms": [], "name": "RBSN_mid", "pathway_ids": ["R-HSA-983231", "R-HSA-168138", "R-MMU-168138", "R-MMU-983231", "R-SCE-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production", "R-HSA-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-168138:r:Toll Like Receptor 9 (TLR9) Cascade", "R-MMU-983231:r:Factors involved in megakaryocyte development and platelet production", "R-SCE-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR063093": {"description": "NudE-type Nudix hydrolase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NudE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063094": {"description": "LasA, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LasA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063095": {"description": "PriA helicase, winged helix domain, bacteroidota", "go_ids": [], "go_terms": [], "name": "WHD_PriA_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063096": {"description": "DNA helicase, middle domain", "go_ids": [], "go_terms": [], "name": "Helicase_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063097": {"description": "Bacterial solute-binding protein, 4-helix bundle domain", "go_ids": [], "go_terms": [], "name": "SBP_bac_4HB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063098": {"description": "PknI serine/threonine-protein kinase, sensor domain", "go_ids": [], "go_terms": [], "name": "PknI_sensor", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063099": {"description": "Bacteriophage P22 Gp10, beta-sandwich", "go_ids": [], "go_terms": [], "name": "P22_Gp10_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063100": {"description": "Serratia CdiI immunity protein-like", "go_ids": [], "go_terms": [], "name": "CdiI_serr", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063101": {"description": "Cyclic-di-GMP receptor FimW, middle PilZ domain", "go_ids": [], "go_terms": [], "name": "FimW_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063102": {"description": "YvlB-like protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YvlB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063103": {"description": "Uncharacterised protein YbyB", "go_ids": [], "go_terms": [], "name": "YbyB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063104": {"description": "YjjJ-like toxin, middle domain", "go_ids": [], "go_terms": [], "name": "YjjJ_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063105": {"description": "Unconventional myosin-IX tail domain", "go_ids": [], "go_terms": [], "name": "MYO9_tail", "pathway_ids": ["R-RNO-9013026", "R-HSA-8980692", "R-RNO-9013424", "R-MMU-9013026", "R-DRE-9013424", "R-MMU-8980692", "R-RNO-8980692", "R-HSA-9013026", "R-DRE-9013026", "R-DRE-8980692", "R-MMU-9013424", "R-HSA-9013424"], "pathways": ["R-RNO-9013026:r:RHOB GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-RNO-9013424:r:RHOV GTPase cycle", "R-MMU-9013026:r:RHOB GTPase cycle", "R-DRE-9013424:r:RHOV GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-RNO-8980692:r:RHOA GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-DRE-9013026:r:RHOB GTPase cycle", "R-DRE-8980692:r:RHOA GTPase cycle", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle"], "type": "Domain"}, "IPR063106": {"description": "Spp1/CFP1, noncanonical C3H-type zinc finger", "go_ids": [], "go_terms": [], "name": "Zf_C3H_Spp1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063107": {"description": "Interferon-induced very large GTPase 1, second domain", "go_ids": [], "go_terms": [], "name": "GVIN1_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063108": {"description": "Perforin-1, EGF domain", "go_ids": [], "go_terms": [], "name": "EGF_PRF1", "pathway_ids": ["R-HSA-9725371"], "pathways": ["R-HSA-9725371:r:Nuclear events stimulated by ALK signaling in cancer"], "type": "Domain"}, "IPR063109": {"description": "CST complex subunit CTC1, fifth domain", "go_ids": [], "go_terms": [], "name": "CTC1_5th", "pathway_ids": ["R-MMU-174430", "R-DRE-174430", "R-MMU-174411", "R-HSA-174411", "R-HSA-174430"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174430:r:Telomere C-strand synthesis initiation"], "type": "Domain"}, "IPR063110": {"description": "ETO1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ETO1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063111": {"description": "LysM11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LysM11_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063112": {"description": "LUMINIDEPENDENS, N-terminal helix", "go_ids": [], "go_terms": [], "name": "LD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063113": {"description": "PMS2CL C-terminal-like disordered region", "go_ids": [], "go_terms": [], "name": "PMS2CL", "pathway_ids": ["R-HSA-5358565", "R-GGA-5358565", "R-HSA-6796648", "R-HSA-5545483", "R-MMU-5358565", "R-HSA-5358606", "R-HSA-5632987"], "pathways": ["R-HSA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-GGA-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-6796648:r:TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-5545483:r:Defective Mismatch Repair Associated With MLH1", "R-MMU-5358565:r:Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "R-HSA-5358606:r:Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "R-HSA-5632987:r:Defective Mismatch Repair Associated With PMS2"], "type": "Domain"}, "IPR063114": {"description": "TRAPPC11, second Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TRAPPC11_2nd", "pathway_ids": ["R-HSA-8876198", "R-DRE-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR063115": {"description": "Serine protease, Ig-like domain, Actinomycetes", "go_ids": [], "go_terms": [], "name": "Ig_Actino", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063116": {"description": "Sll0103-like, C-terminal alpha-helical domain", "go_ids": [], "go_terms": [], "name": "Sll0103_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063117": {"description": "Nup54, alpha/beta domain", "go_ids": [], "go_terms": [], "name": "Nup54_a-b", "pathway_ids": ["R-RNO-4615885", "R-HSA-180910", "R-RNO-3371453", "R-MMU-3232142", "R-HSA-3108214", "R-HSA-191859", "R-HSA-9705671", "R-RNO-3301854", "R-MMU-4570464", "R-DME-159236", "R-DME-159231", "R-DME-4085377", "R-RNO-3108214", "R-HSA-170822", "R-HSA-1169408", "R-MMU-4615885", "R-MMU-159230", "R-HSA-159227", "R-HSA-159230", "R-HSA-168333", "R-RNO-159230", "R-MMU-4551638", "R-MMU-4085377", "R-RNO-191859", "R-HSA-3371453", "R-HSA-165054", "R-HSA-4570464", "R-DME-4615885", "R-RNO-159236", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-DME-3108214", "R-MMU-3371453", "R-HSA-9610379", "R-DME-3371453", "R-HSA-168276", "R-HSA-168271", "R-HSA-6784531", "R-MMU-3301854", "R-DME-4551638", "R-HSA-4085377", "R-HSA-168325", "R-DME-159227", "R-MMU-170822", "R-RNO-159227", "R-HSA-9609690", "R-MMU-159236", "R-HSA-159231", "R-RNO-4551638", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-RNO-4085377", "R-HSA-9615933", "R-DME-159230", "R-RNO-170822", "R-DME-3301854", "R-RNO-159231", "R-RNO-4570464", "R-HSA-5619107", "R-RNO-3232142", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746"], "pathways": ["R-RNO-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-RNO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DME-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DME-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-RNO-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-RNO-191859:r:snRNP Assembly", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-DME-4615885:r:SUMOylation of DNA replication proteins", "R-RNO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DME-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-DME-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DME-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-DME-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-RNO-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-9609690:r:HCMV Early Events", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-RNO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-9615933:r:Postmitotic nuclear pore complex (NPC) reformation", "R-DME-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-RNO-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-DME-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-RNO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-RNO-4570464:r:SUMOylation of RNA binding proteins", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-RNO-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein"], "type": "Domain"}, "IPR063118": {"description": "CST complex subunit CTC1, second domain", "go_ids": [], "go_terms": [], "name": "CTC1_2nd", "pathway_ids": ["R-MMU-174411", "R-MMU-174430", "R-HSA-174430", "R-HSA-174411"], "pathways": ["R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174430:r:Telomere C-strand synthesis initiation", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere"], "type": "Domain"}, "IPR063119": {"description": "Tail-anchor membrane protein", "go_ids": [], "go_terms": [], "name": "TA_Actino", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063120": {"description": "ARB_06334-like, middle domain", "go_ids": [], "go_terms": [], "name": "ARB_06334_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063121": {"description": "Ubiquitination network protein AcrB, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AcrB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063122": {"description": "PnsB5, helical domain", "go_ids": [], "go_terms": [], "name": "PnsB5_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063123": {"description": "Fra a 1-associated protein, C-terminal helix", "go_ids": [], "go_terms": [], "name": "FaAP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063124": {"description": "Penicillin-binding protein 1A, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PBP_1A_C", "pathway_ids": ["PWY-6471", "PWY-5265"], "pathways": ["PWY-6471:t:peptidoglycan biosynthesis IV (Enterococcus faecium)", "PWY-5265:t:peptidoglycan biosynthesis II (staphylococci)"], "type": "Domain"}, "IPR063125": {"description": "TRAPPC10, third Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TRAPPC10_3rd", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-HSA-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR063126": {"description": "Poly-gamma-glutamate synthase CapB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CapB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063127": {"description": "RnfG, N-terminal helix", "go_ids": [], "go_terms": [], "name": "RnfG_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063128": {"description": "CoxE-like, N-terminal helical bundle domain", "go_ids": [], "go_terms": [], "name": "CoxE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063129": {"description": "YLL032C-like, fifth KH domain-like", "go_ids": [], "go_terms": [], "name": "KH_YLL032C_5th-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063130": {"description": "NPLP1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NPLP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063131": {"description": "Ropporin, middle domain", "go_ids": [], "go_terms": [], "name": "Ropporin_M", "pathway_ids": ["R-HSA-5666185"], "pathways": ["R-HSA-5666185:r:RHO GTPases Activate Rhotekin and Rhophilins"], "type": "Domain"}, "IPR063132": {"description": "HpcH/HpaI aldolase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HpcH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063133": {"description": "Uncharacterised protein YkzP", "go_ids": [], "go_terms": [], "name": "YkzP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063134": {"description": "DNA topoisomerase 4 subunit A, C-terminal domain, Bacteroidota", "go_ids": [], "go_terms": [], "name": "Topo_CTD_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063135": {"description": "TRAPPC11, first Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TRAPPC11_1st", "pathway_ids": ["R-HSA-8876198", "R-DRE-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR063136": {"description": "YfhP, C-terminal alpha/beta plait domain", "go_ids": [], "go_terms": [], "name": "YfhP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063137": {"description": "Diguanylate cyclase DgcQ, linker domain", "go_ids": [], "go_terms": [], "name": "DgcQ_link", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063138": {"description": "Flagellar regulatory protein FliZ, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FliZ_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063139": {"description": "SENP6/SENP7, PH-like domain", "go_ids": [], "go_terms": [], "name": "PH_SENP67", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063140": {"description": "RMD9, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RMD9_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063141": {"description": "Phosphoglycerol transferase I, third domain", "go_ids": [], "go_terms": [], "name": "OpgB_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063142": {"description": "Tel1, pincer domain", "go_ids": [], "go_terms": [], "name": "HEAT_Pincer_Tel1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063143": {"description": "AbpF, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AbpF_C_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063144": {"description": "Uncharacterised protein YfaP, N-terminal Ig-like domain", "go_ids": [], "go_terms": [], "name": "YfaP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063145": {"description": "CST complex subunit CTC1, fourth domain", "go_ids": [], "go_terms": [], "name": "CTC1_4th", "pathway_ids": ["R-MMU-174430", "R-DRE-174430", "R-MMU-174411", "R-HSA-174411", "R-HSA-174430"], "pathways": ["R-MMU-174430:r:Telomere C-strand synthesis initiation", "R-DRE-174430:r:Telomere C-strand synthesis initiation", "R-MMU-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174411:r:Polymerase switching on the C-strand of the telomere", "R-HSA-174430:r:Telomere C-strand synthesis initiation"], "type": "Domain"}, "IPR063146": {"description": "TNF receptor grnd, cysteine-rich domain", "go_ids": [], "go_terms": [], "name": "TNFR_grnd_CRD", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063147": {"description": "BcsE, degenerate GGDEF domain", "go_ids": [], "go_terms": [], "name": "BcsE_C", "pathway_ids": ["R-HSA-9931953"], "pathways": ["R-HSA-9931953:r:Biofilm formation"], "type": "Domain"}, "IPR063148": {"description": "RNF213, AAA domain 1", "go_ids": [], "go_terms": [], "name": "AAA_RNF213_1", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7250", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7511", "PWY-7887", "PWY-6841", "R-DRE-983168", "R-HSA-983168", "R-HSA-9725370", "R-HSA-9635465", "R-MMU-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7511:t:protein ubiquitination", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR063149": {"description": "HssS heme sensor protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HssS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063150": {"description": "Actin-binding protein F, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ABPF_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063151": {"description": "PilY1 homolog, second domain", "go_ids": [], "go_terms": [], "name": "PilY1_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063152": {"description": "Penicillin-binding protein 1B, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PBP1b_C", "pathway_ids": ["R-HSA-9638771"], "pathways": ["R-HSA-9638771:r:Action of antimicrobials"], "type": "Domain"}, "IPR063153": {"description": "Actin filament-associated protein 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "AFAP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063154": {"description": "Soluble lytic transglycosylase, C-terminal LysM-like domain", "go_ids": [], "go_terms": [], "name": "LysM_SLT_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063155": {"description": "UBR5, first HEAT repeat domain", "go_ids": [], "go_terms": [], "name": "HEAT_UBR5_1st", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR063156": {"description": "DENND6, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DENND6_C", "pathway_ids": ["R-HSA-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR063157": {"description": "SHOC1, helix-hairpin-helix domain", "go_ids": [], "go_terms": [], "name": "SHOC1_2HhH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063158": {"description": "LarB/PurE-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LarB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063159": {"description": "Small integral membrane protein 36", "go_ids": [], "go_terms": [], "name": "SMIM36", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063160": {"description": "SorCS receptor, membrane-proximal stalk domain", "go_ids": [], "go_terms": [], "name": "SorCS_stalk", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063161": {"description": "Sphingomyelin phosphodiesterase 3/5, N-terminal transmembrane region", "go_ids": [], "go_terms": [], "name": "NSMase_N", "pathway_ids": ["PWY-7277", "R-MMU-9840310", "R-RNO-9840310", "R-MMU-5626978", "R-RNO-5626978", "R-HSA-9840310", "R-HSA-5626978"], "pathways": ["PWY-7277:t:sphingolipid biosynthesis (mammals)", "R-MMU-9840310:r:Glycosphingolipid catabolism", "R-RNO-9840310:r:Glycosphingolipid catabolism", "R-MMU-5626978:r:TNFR1-mediated ceramide production", "R-RNO-5626978:r:TNFR1-mediated ceramide production", "R-HSA-9840310:r:Glycosphingolipid catabolism", "R-HSA-5626978:r:TNFR1-mediated ceramide production"], "type": "Domain"}, "IPR063162": {"description": "Chromosome partition protein MukB, helical domain", "go_ids": [], "go_terms": [], "name": "MukB_hel", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063163": {"description": "BaeS, Cache-like sensory domain", "go_ids": [], "go_terms": [], "name": "Cache_BaeS_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063164": {"description": "Small cysteine and glycine repeat-containing protein", "go_ids": [], "go_terms": [], "name": "SCYGR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063165": {"description": "PAC, N-terminal coiled-coil domain", "go_ids": [], "go_terms": [], "name": "PAC_N_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063166": {"description": "GadE/DctR transcriptional regulator, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GadE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063167": {"description": "Cilia and flagella-associated protein 70, helical domain", "go_ids": [], "go_terms": [], "name": "CFAP70_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063168": {"description": "Short neuropeptide F precursor", "go_ids": [], "go_terms": [], "name": "SNPF_precur", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063169": {"description": "GtrB-like, C-terminal hairpin", "go_ids": [], "go_terms": [], "name": "GtrB_C", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR063170": {"description": "CLEC14A, middle domain", "go_ids": [], "go_terms": [], "name": "CLEC14A_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063171": {"description": "Winged helix C-terminal domain", "go_ids": [], "go_terms": [], "name": "WHD_C_halo", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063172": {"description": "RNF213, AAA domain 6", "go_ids": [], "go_terms": [], "name": "AAA_RNF213_6", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7250", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7511", "PWY-7887", "PWY-6841", "R-DRE-983168", "R-HSA-983168", "R-HSA-9725370", "R-HSA-9635465", "R-MMU-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7511:t:protein ubiquitination", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR063173": {"description": "CTF3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CTF3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063174": {"description": "Peptidase M3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Peptidase_M3_N_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063175": {"description": "RecQ helicase-like, winged-helix domain, Bacteroidota", "go_ids": [], "go_terms": [], "name": "WHD_RecQ_mid_bact", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063176": {"description": "ABC1 kinase 3-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ABC1K3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063177": {"description": "Actin filament-associated protein 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AFAP_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063178": {"description": "NUDT19, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NUDT19_C", "pathway_ids": ["PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-390918", "R-MMU-390918", "R-RNO-9033241", "R-GGA-390918", "R-RNO-390918", "R-MMU-9033241", "R-GGA-9033241", "R-HSA-9033241", "PWY-7821", "PWY-7419"], "pathways": ["PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-MMU-390918:r:Peroxisomal lipid metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-GGA-390918:r:Peroxisomal lipid metabolism", "R-RNO-390918:r:Peroxisomal lipid metabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-GGA-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis"], "type": "Domain"}, "IPR063179": {"description": "Acyloxyacyl hydrolase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PagL_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063180": {"description": "CPL1/2, SPOC domain", "go_ids": [], "go_terms": [], "name": "SPOC_CPL1_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063181": {"description": "YMR124W-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YMR124W_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063182": {"description": "Transcription factor, C-terminal domain, fungi", "go_ids": [], "go_terms": [], "name": "Fungal_trans_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063183": {"description": "YchO, Ig-like domain", "go_ids": [], "go_terms": [], "name": "YchO_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063184": {"description": "Ribosomal protein uL15, N-terminal region", "go_ids": [], "go_terms": [], "name": "Ribosomal_uL15_N", "pathway_ids": ["R-BTA-5389840", "R-HSA-5419276", "R-MMU-9937383", "R-DRE-9937383", "R-HSA-5368286", "R-MMU-5419276", "R-BTA-5419276", "R-HSA-9937383", "R-HSA-5389840", "R-MMU-5389840", "R-DRE-5389840", "R-BTA-9937383", "R-DRE-5419276"], "pathways": ["R-BTA-5389840:r:Mitochondrial translation elongation", "R-HSA-5419276:r:Mitochondrial translation termination", "R-MMU-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5368286:r:Mitochondrial translation initiation", "R-MMU-5419276:r:Mitochondrial translation termination", "R-BTA-5419276:r:Mitochondrial translation termination", "R-HSA-9937383:r:Mitochondrial ribosome-associated quality control", "R-HSA-5389840:r:Mitochondrial translation elongation", "R-MMU-5389840:r:Mitochondrial translation elongation", "R-DRE-5389840:r:Mitochondrial translation elongation", "R-BTA-9937383:r:Mitochondrial ribosome-associated quality control", "R-DRE-5419276:r:Mitochondrial translation termination"], "type": "Domain"}, "IPR063185": {"description": "Inhibitor of host cell division protein domain", "go_ids": [], "go_terms": [], "name": "Gp56", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063186": {"description": "Defect at low temperature protein 1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DLT1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063187": {"description": "TRAPPC11, third Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_TRAPPC11_3rd", "pathway_ids": ["R-HSA-8876198", "R-DRE-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR063188": {"description": "Phosphotransferase RcsD, N-terminal domain", "go_ids": [], "go_terms": [], "name": "RcsD_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063189": {"description": "COS11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "COS111_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063190": {"description": "RNF213, AAA domain 2", "go_ids": [], "go_terms": [], "name": "AAA_RNF213_2", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7250", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7511", "PWY-7887", "PWY-6841", "R-DRE-983168", "R-HSA-983168", "R-HSA-9725370", "R-HSA-9635465", "R-MMU-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7511:t:protein ubiquitination", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR063191": {"description": "HNH endonuclease-associated, N-terminal domain", "go_ids": [], "go_terms": [], "name": "HNH_assoc_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063192": {"description": "TPLATE, immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "TPLATE_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063193": {"description": "PTPRO, sixth Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_PTPRO_6th", "pathway_ids": ["R-HSA-9034015"], "pathways": ["R-HSA-9034015:r:Signaling by NTRK3 (TRKC)"], "type": "Domain"}, "IPR063194": {"description": "NrdJ homologue, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NrdJ_rel_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063195": {"description": "Cellulose synthase BcsB-like, first FD domain", "go_ids": [], "go_terms": [], "name": "FD_BcsB_1st", "pathway_ids": ["R-HSA-9931953"], "pathways": ["R-HSA-9931953:r:Biofilm formation"], "type": "Domain"}, "IPR063196": {"description": "YonV, middle domain", "go_ids": [], "go_terms": [], "name": "YonV_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063197": {"description": "DNA polymerase-epsilon, first zinc finger domain", "go_ids": [], "go_terms": [], "name": "Zf_DPOE_2", "pathway_ids": ["R-DDI-6782135", "R-DME-110314", "R-HSA-5685942", "R-MMU-6782135", "R-SPO-5656169", "R-HSA-5696397", "R-DDI-6782210", "R-MMU-110314", "R-DDI-68952", "R-DME-68962", "R-DDI-68962", "R-HSA-68962", "R-HSA-6782210", "R-DME-68952", "R-HSA-5656169", "R-DME-6782135", "R-SCE-68952", "R-MMU-5696400", "R-SPO-5696397", "R-DME-5651801", "R-HSA-68952", "R-MMU-68962", "R-MMU-5651801", "R-MMU-5656169", "R-HSA-6782135", "R-MMU-5685942", "R-HSA-5651801", "R-SCE-68962", "R-MMU-68952", "R-DME-5656169", "R-SPO-5696400", "R-SPO-68952", "R-DME-5696400", "R-SPO-6782210", "R-SPO-110314", "R-SPO-68962", "R-HSA-5696400", "R-HSA-110314", "R-MMU-6782210", "R-SPO-6782135", "R-MMU-5696397", "R-SCE-6782135", "R-SPO-5651801"], "pathways": ["R-DDI-6782135:r:Dual incision in TC-NER", "R-DME-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-HSA-5685942:r:HDR through Homologous Recombination (HRR)", "R-MMU-6782135:r:Dual incision in TC-NER", "R-SPO-5656169:r:Termination of translesion DNA synthesis", "R-HSA-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DDI-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-MMU-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-DDI-68952:r:DNA replication initiation", "R-DME-68962:r:Activation of the pre-replicative complex", "R-DDI-68962:r:Activation of the pre-replicative complex", "R-HSA-68962:r:Activation of the pre-replicative complex", "R-HSA-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-DME-68952:r:DNA replication initiation", "R-HSA-5656169:r:Termination of translesion DNA synthesis", "R-DME-6782135:r:Dual incision in TC-NER", "R-SCE-68952:r:DNA replication initiation", "R-MMU-5696400:r:Dual Incision in GG-NER", "R-SPO-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-DME-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-HSA-68952:r:DNA replication initiation", "R-MMU-68962:r:Activation of the pre-replicative complex", "R-MMU-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-MMU-5656169:r:Termination of translesion DNA synthesis", "R-HSA-6782135:r:Dual incision in TC-NER", "R-MMU-5685942:r:HDR through Homologous Recombination (HRR)", "R-HSA-5651801:r:PCNA-Dependent Long Patch Base Excision Repair", "R-SCE-68962:r:Activation of the pre-replicative complex", "R-MMU-68952:r:DNA replication initiation", "R-DME-5656169:r:Termination of translesion DNA synthesis", "R-SPO-5696400:r:Dual Incision in GG-NER", "R-SPO-68952:r:DNA replication initiation", "R-DME-5696400:r:Dual Incision in GG-NER", "R-SPO-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-SPO-68962:r:Activation of the pre-replicative complex", "R-HSA-5696400:r:Dual Incision in GG-NER", "R-HSA-110314:r:Recognition of DNA damage by PCNA-containing replication complex", "R-MMU-6782210:r:Gap-filling DNA repair synthesis and ligation in TC-NER", "R-SPO-6782135:r:Dual incision in TC-NER", "R-MMU-5696397:r:Gap-filling DNA repair synthesis and ligation in GG-NER", "R-SCE-6782135:r:Dual incision in TC-NER", "R-SPO-5651801:r:PCNA-Dependent Long Patch Base Excision Repair"], "type": "Domain"}, "IPR063198": {"description": "PEX8, second domain", "go_ids": [], "go_terms": [], "name": "PEX8_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063199": {"description": "Eisosome protein SEG1/2", "go_ids": [], "go_terms": [], "name": "SEG1/2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063200": {"description": "ZC3H3, middle domain", "go_ids": [], "go_terms": [], "name": "ZC3H3_M", "pathway_ids": ["R-DME-9930044"], "pathways": ["R-DME-9930044:r:Nuclear RNA decay"], "type": "Domain"}, "IPR063201": {"description": "TNFSF4, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TNFSF4_N", "pathway_ids": ["R-RNO-5669034", "R-HSA-5669034", "R-MMU-5669034"], "pathways": ["R-RNO-5669034:r:TNFs bind their physiological receptors", "R-HSA-5669034:r:TNFs bind their physiological receptors", "R-MMU-5669034:r:TNFs bind their physiological receptors"], "type": "Domain"}, "IPR063202": {"description": "TP0088-like", "go_ids": [], "go_terms": [], "name": "TP0088", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063203": {"description": "CbiD, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CbiD_C", "pathway_ids": ["PWY-7377"], "pathways": ["PWY-7377:t:cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "type": "Domain"}, "IPR063204": {"description": "PVC7, LysM-like domain", "go_ids": [], "go_terms": [], "name": "LysM-like_PVC7", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063205": {"description": "Uncharacterised protein PM1101", "go_ids": [], "go_terms": [], "name": "PM1101", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063206": {"description": "F22D3.4, C-terminal domain", "go_ids": [], "go_terms": [], "name": "F22D3_4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063207": {"description": "Mucin-20, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MUC20_C", "pathway_ids": ["R-HSA-5083632", "R-HSA-5083636", "R-MMU-8851805", "R-MMU-913709", "R-HSA-977068", "R-HSA-5083625", "R-MMU-977068", "R-HSA-5621480", "R-HSA-8851805", "R-HSA-913709"], "pathways": ["R-HSA-5083632:r:Defective C1GALT1C1 causes TNPS", "R-HSA-5083636:r:Defective GALNT12 causes CRCS1", "R-MMU-8851805:r:MET activates RAS signaling", "R-MMU-913709:r:O-linked glycosylation of mucins", "R-HSA-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5083625:r:Defective GALNT3 causes HFTC", "R-MMU-977068:r:Termination of O-glycan biosynthesis", "R-HSA-5621480:r:Dectin-2 family", "R-HSA-8851805:r:MET activates RAS signaling", "R-HSA-913709:r:O-linked glycosylation of mucins"], "type": "Domain"}, "IPR063208": {"description": "Type I restriction enzyme methylase subunit, C-terminal domain", "go_ids": [], "go_terms": [], "name": "HsdM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063209": {"description": "Contractile injection system associated ATPase, helical domain", "go_ids": [], "go_terms": [], "name": "CIS_ATPase_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063210": {"description": "Glideosome-associated protein 45", "go_ids": [], "go_terms": [], "name": "GAP45", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063211": {"description": "CNKSR/IPCEF1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CNKSR_C", "pathway_ids": ["R-MMU-5674135", "R-HSA-5674135", "R-HSA-6802948", "R-HSA-9649948", "R-HSA-6802952", "R-HSA-6802946", "R-RNO-5674135", "R-HSA-6802955", "R-HSA-9656223"], "pathways": ["R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-RNO-5674135:r:MAP2K and MAPK activation", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Domain"}, "IPR063212": {"description": "Baseplate J-like, alpha/beta domain", "go_ids": [], "go_terms": [], "name": "Baseplate_J_ab", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063213": {"description": "YdhS-like, middle domain", "go_ids": [], "go_terms": [], "name": "YdhS_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063214": {"description": "Uncharacterized protein pXO2-05/BXB0004/GBAA_pXO2_0004, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_pXO2-05", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063215": {"description": "SSY5, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SSY5_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063217": {"description": "HUA1, probable zinc finger domain", "go_ids": [], "go_terms": [], "name": "Znf_HUA1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063218": {"description": "Genetic interactor of prohibitins 3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GEP3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063219": {"description": "Rhizobiales growth-associated beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "Rgs_b-sand", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063220": {"description": "BUD4, C2-like domain", "go_ids": [], "go_terms": [], "name": "BUD4_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063221": {"description": "At4g37920-like, middle domain", "go_ids": [], "go_terms": [], "name": "At4g37920_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063222": {"description": "SKG1-like domain", "go_ids": [], "go_terms": [], "name": "SKG1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063223": {"description": "Tel1, spiral domain", "go_ids": [], "go_terms": [], "name": "HEAT_Spiral_Tel1", "pathway_ids": ["R-SCE-2559586", "R-SCE-5693548", "R-SCE-5693565", "R-SCE-9664873"], "pathways": ["R-SCE-2559586:r:DNA Damage/Telomere Stress Induced Senescence", "R-SCE-5693548:r:Sensing of DNA Double Strand Breaks", "R-SCE-5693565:r:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-SCE-9664873:r:Pexophagy"], "type": "Domain"}, "IPR063224": {"description": "IPGAL2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "IPGAL2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063225": {"description": "Conditioned medium factor, first Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_CMFA_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063226": {"description": "Galacturonosyltransferase, helical domain", "go_ids": [], "go_terms": [], "name": "GAUT_helical", "pathway_ids": ["PWY-5321", "PWY-7045", "PWY-7530", "PWY-8211", "PWY-7487", "PWY-7940", "PWY-6655", "PWY-7137", "PWY-7885", "PWY-5666", "PWY-6722", "PWY-8209", "PWY-4421", "PWY-7824", "PWY-6024", "PWY-8322", "PWY-7921", "PWY-5797", "PWY-8232", "PWY-6658", "PWY-7166", "PWY-7743", "PWY-8233", "PWY-7100", "PWY-8221", "PWY-7677", "PWY-7151", "PWY-6385", "PWY-7412", "PWY-6239", "PWY-7449", "PWY-6310", "PWY-8218", "PWY-7981", "PWY-5399", "PWY-8206", "PWY-7820", "PWY-641", "PWY-8461", "PWY-7922", "PWY-5774", "PWY-8236", "PWY-8226", "PWY-7491", "PWY-7658", "PWY-7624", "PWY-8220", "PWY-6525", "PWY-8217", "PWY-7458", "PWY-7071", "PWY-4801", "PWY-6279", "PWY-8081", "PWY-8251", "PWY-8204", "PWY-7150", "PWY-8459", "PWY-8234", "PWY-5129", "PWY-8235", "PWY-7819", "PWY-7191", "PWY-7212", "PWY-8133", "PWY-8241", "PWY-1901", "PWY-7745", "PWY-7055", "PWY-5139", "PWY-7143", "PWY-8365", "PWY-5936", "PWY-7623", "PWY-5338", "PWY-5759", "PWY-6972", "PWY-8447", "PWY-7475", "PWY-8122", "PWY-7171", "PWY-8252", "PWY-5339", "PWY-5310", "PWY-8253", "PWY-5286", "PWY-7139", "PWY-8250", "PWY-5800", "PWY-7192", "PWY-6036", "PWY-8219", "PWY-7140", "PWY-7463", "PWY-8379", "PWY-5784", "PWY-6546", "PWY-6297", "PWY-8224", "PWY-7569", "PWY-6624", "PWY-6763", "PWY-5313", "PWY-8243", "PWY-6397", "PWY-8205", "PWY-8323", "PWY-7960", "PWY-7838", "PWY-1961", "PWY-8207", "PWY-7897", "PWY-5284", "PWY-7186", "PWY-822", "PWY-6657", "PWY-8230", "PWY-7818", "PWY-5822", "PWY-5756", "PWY-7859", "PWY-5975", "PWY-7145", "PWY-1981", "PWY-8460", "PWY-5793", "PWY-5320", "PWY-6010", "PWY-8244", "PWY-6762", "PWY-7450", "PWY-6312", "PWY-5342", "PWY-8367", "PWY-6051", "PWY-8212", "PWY-2881", "PWY-5160", "PWY-7946", "PWY-8257", "PWY-7945", "PWY-8208", "PWY-7821", "PWY-7460", "PWY-7213", "PWY-83", "PWY-8237", "PWY-5094", "PWY-5312", "PWY-5875", "PWY-5105", "PWY-6802", "PWY-6401", "PWY-8248", "PWY-5343", "PWY-5380", "PWY-7109", "PWY-7157", "PWY-7633", "PWY-6623", "PWY-2902", "PWY-7464", "PWY-5379", "PWY-5672", "PWY-7473", "PWY-8272", "PWY-7074", "PWY-7740", "PWY-8000", "PWY-5317", "PWY-7129", "PWY-7253", "PWY-5397", "PWY-8039", "PWY-8242", "PWY-7252", "PWY-8340", "PWY-8228", "PWY-2901", "PWY-2021", "PWY-8434", "PWY-7018", "PWY-7352", "PWY-7058", "PWY-7468", "PWY-5926", "PWY-8408", "PWY-8371", "PWY-7037", "PWY-8222", "PWY-5268", "PWY-6346", "PWY-7570", "PWY-7661", "PWY-5161", "PWY-6015", "PWY-6971", "PWY-5400", "PWY-7697"], "pathways": ["PWY-5321:t:quercetin glycoside biosynthesis (Arabidopsis)", "PWY-7045:t:mithramycin biosynthesis", "PWY-7530:t:Escherichia coli serotype O:104 O antigen biosynthesis", "PWY-8211:t:Escherichia coli serotype O:7 O antigen biosynthesis", "PWY-7487:t:(+)-secoisolariciresinol diglucoside biosynthesis", "PWY-7940:t:lauryl-hydroxychlorobactene glucoside biosynthesis", "PWY-6655:t:xanthan biosynthesis", "PWY-7137:t:quercetin gentiotetraside biosynthesis", "PWY-7885:t:phosphatidylinositol mannoside biosynthesis", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-6722:t:candicidin biosynthesis", "PWY-8209:t:Escherichia coli serotype O:15 O antigen biosynthesis", "PWY-4421:t:curcumin glucoside biosynthesis", "PWY-7824:t:prunasin and amygdalin biosynthesis", "PWY-6024:t:isovitexin glycosides biosynthesis", "PWY-8322:t:protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)", "PWY-7921:t:protein O-mannosylation I (yeast)", "PWY-5797:t:indole-3-acetate inactivation VI", "PWY-8232:t:Shigella boydii serotype 6 O antigen biosynthesis", "PWY-6658:t:acetan biosynthesis", "PWY-7166:t:kaempferide triglycoside biosynthesis", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-8233:t:Escherichia coli serotype O:169 O antigen biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-8221:t:Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis", "PWY-7677:t:rosamicin biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-6385:t:peptidoglycan biosynthesis III (mycobacteria)", "PWY-7412:t:mycinamicin biosynthesis", "PWY-6239:t:luteolin glycosides biosynthesis", "PWY-7449:t:acylated cyanidin galactoside biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-8218:t:Escherichia coli serotype O:56 O antigen biosynthesis", "PWY-7981:t:alpha-dystroglycan glycosylation", "PWY-5399:t:betacyanin biosynthesis", "PWY-8206:t:Salmonella enterica serotype O:18 O antigen biosynthesis", "PWY-7820:t:teichuronic acid biosynthesis (B. subtilis 168)", "PWY-641:t:proanthocyanidins biosynthesis from flavanols", "PWY-8461:t:Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis", "PWY-7922:t:protein O-mannosylation II (mammals, core M1 and core M2)", "PWY-5774:t:saponin biosynthesis IV", "PWY-8236:t:Salmonella enterica serotype O:39 O antigen biosynthesis", "PWY-8226:t:Escherichia coli serotype O:152 O antigen biosynthesis", "PWY-7491:t:podophyllotoxin glucosides metabolism", "PWY-7658:t:protein N-glycosylation (Methanococcus voltae)", "PWY-7624:t:nystatin biosynthesis", "PWY-8220:t:Escherichia coli serotype O:117 O antigen biosynthesis", "PWY-6525:t:stellariose and mediose biosynthesis", "PWY-8217:t:Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis", "PWY-7458:t:violdelphin biosynthesis", "PWY-7071:t:steviol glucoside biosynthesis (rebaudioside A biosynthesis)", "PWY-4801:t:aloesone and aloesin biosynthesis", "PWY-6279:t:myxol-2' fucoside biosynthesis", "PWY-8081:t:leucine-derived hydroxynitrile glucoside biosynthesis", "PWY-8251:t:Escherichia coli serotype O:2 O antigen biosynthesis", "PWY-8204:t:Salmonella enterica serotype O:54 O antigen biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-8459:t:human milk oligisaccharides biosynthesis", "PWY-8234:t:Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis", "PWY-5129:t:sphingolipid biosynthesis (plants)", "PWY-8235:t:Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis", "PWY-7819:t:poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis", "PWY-7191:t:kaempferol diglycoside biosynthesis (pollen-specific)", "PWY-7212:t:baicalein metabolism", "PWY-8133:t:succinoglycan biosynthesis", "PWY-8241:t:Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis", "PWY-1901:t:aurone biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-7055:t:daphnetin modification", "PWY-5139:t:pelargonidin conjugates biosynthesis", "PWY-7143:t:kaempferol gentiobioside biosynthesis", "PWY-8365:t:C25,25 CDP-archaeol biosynthesis", "PWY-5936:t:xyloglucan biosynthesis", "PWY-7623:t:astaxanthin dirhamnoside biosynthesis", "PWY-5338:t:galactosylcyclitol biosynthesis", "PWY-5759:t:saponin biosynthesis III", "PWY-6972:t:oleandomycin activation/inactivation", "PWY-8447:t:carminate biosynthesis", "PWY-7475:t:des-methyl avenacin A-1 biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7171:t:flavonol acylglucoside biosynthesis II - isorhamnetin derivatives", "PWY-8252:t:Escherichia coli serotype O:50 O antigen biosynthesis", "PWY-5339:t:chalcone 2'-O-glucoside biosynthesis", "PWY-5310:t:superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)", "PWY-8253:t:Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis", "PWY-5286:t:anthocyanidin sophoroside metabolism", "PWY-7139:t:sesaminol glucoside biosynthesis", "PWY-8250:t:Escherichia coli serotype O:9 O antigen biosynthesis", "PWY-5800:t:xylan biosynthesis", "PWY-7192:t:quercetin diglycoside biosynthesis (pollen-specific)", "PWY-6036:t:cardenolide glucosides biosynthesis", "PWY-8219:t:Escherichia coli serotype O:107 O antigen biosynthesis", "PWY-7140:t:myricetin gentiobioside biosynthesis", "PWY-7463:t:N-methylanthraniloyl-beta-D-glucopyranose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-5784:t:indole-3-acetate inactivation VIII", "PWY-6546:t:brassinosteroids inactivation", "PWY-6297:t:tuberonate glucoside biosynthesis", "PWY-8224:t:Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-6624:t:salicylate glucosides biosynthesis III", "PWY-6763:t:salicortin biosynthesis", "PWY-5313:t:superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)", "PWY-8243:t:colanic acid (Escherichia coli K12) biosynthesis", "PWY-6397:t:mycolyl-arabinogalactan-peptidoglycan complex biosynthesis", "PWY-8205:t:Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis", "PWY-8323:t:protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)", "PWY-7960:t:rhabduscin biosynthesis", "PWY-7838:t:globo-series glycosphingolipids biosynthesis", "PWY-1961:t:indole-3-acetate inactivation I", "PWY-8207:t:Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis", "PWY-7897:t:flavonoid di-C-glucosylation", "PWY-5284:t:shisonin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-822:t:fructan biosynthesis", "PWY-6657:t:polyhydroxydecanoate biosynthesis", "PWY-8230:t:Salmonella enterica serotype O:13 O antigen biosynthesis", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-5822:t:trichloroethene degradation", "PWY-5756:t:saponin biosynthesis II", "PWY-7859:t:jasmonoyl-L-isoleucine inactivation", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-7145:t:genistin gentiobioside biosynthesis", "PWY-1981:t:indole-3-acetate inactivation III", "PWY-8460:t:Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis", "PWY-5793:t:maysin biosynthesis", "PWY-5320:t:kaempferol glycoside biosynthesis (Arabidopsis)", "PWY-6010:t:apigenin glycosides biosynthesis", "PWY-8244:t:Escherichia coli serotype O:177 O antigen biosynthesis", "PWY-6762:t:salicylate glucosides biosynthesis IV", "PWY-7450:t:anthocyanidin modification (Arabidopsis)", "PWY-6312:t:aloin biosynthesis", "PWY-5342:t:ajugose biosynthesis I (galactinol-dependent)", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6051:t:2,4,6-trinitrotoluene degradation", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-2881:t:cytokinins 7-N-glucoside biosynthesis", "PWY-5160:t:rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)", "PWY-7946:t:sarcinaxanthin diglucoside biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-7945:t:2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis", "PWY-8208:t:Salmonella enterica serotype O:6,7 O antigen biosynthesis", "PWY-7821:t:tunicamycin biosynthesis", "PWY-7460:t:2-O-acetyl-3-O-trans-coutarate biosynthesis", "PWY-7213:t:wogonin metabolism", "PWY-83:t:monolignol glucosides biosynthesis", "PWY-8237:t:Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis", "PWY-5094:t:naringenin glycoside biosynthesis", "PWY-5312:t:superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)", "PWY-5875:t:staphyloxanthin biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-6802:t:salidroside biosynthesis", "PWY-6401:t:hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis", "PWY-8248:t:lipid A-core biosynthesis (P. gingivalis)", "PWY-5343:t:ajugose biosynthesis II (galactinol-independent)", "PWY-5380:t:A series fagopyritols biosynthesis", "PWY-7109:t:megalomicin A biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7633:t:calycosin 7-O-glucoside biosynthesis", "PWY-6623:t:salicylate glucosides biosynthesis II", "PWY-2902:t:cytokinin-O-glucosides biosynthesis", "PWY-7464:t:cyanidin 3,7-diglucoside polyacylation biosynthesis", "PWY-5379:t:B series fagopyritols biosynthesis", "PWY-5672:t:ginsenosides biosynthesis", "PWY-7473:t:avenacin A-1 biosynthesis", "PWY-8272:t:Escherichia coli serotype O:49 O antigen biosynthesis", "PWY-7074:t:phenylethanol glycoconjugate biosynthesis", "PWY-7740:t:beta-D-mannosyl phosphomycoketide biosynthesis", "PWY-8000:t:vitamin K degradation", "PWY-5317:t:tropane alkaloids biosynthesis", "PWY-7129:t:quercetin glucoside biosynthesis (Allium)", "PWY-7253:t:apigeninidin 5-O-glucoside biosynthesis", "PWY-5397:t:crocetin biosynthesis", "PWY-8039:t:mitomycin biosynthesis", "PWY-8242:t:Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis", "PWY-7252:t:luteolinidin 5-O-glucoside biosynthesis", "PWY-8340:t:isoorientin biosynthesis II", "PWY-8228:t:Porphyromonas gingivalis O-LPS antigen biosynthesis", "PWY-2901:t:cytokinins 9-N-glucoside biosynthesis", "PWY-2021:t:indole-3-acetate inactivation IV", "PWY-8434:t:cucurbitacin biosynthesis", "PWY-7018:t:paromomycin biosynthesis", "PWY-7352:t:daunorubicin biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7468:t:benzoyl-beta-D-glucopyranose biosynthesis", "PWY-5926:t:afrormosin conjugates interconversion", "PWY-8408:t:erinacine biosynthesis", "PWY-8371:t:mannosylerythritol lipids biosynthesis", "PWY-7037:t:protein O-glycosylation (Neisseria)", "PWY-8222:t:Escherichia coli serotype O:128 O antigen biosynthesis", "PWY-5268:t:salvianin biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-5161:t:6'-deoxychalcone metabolism", "PWY-6015:t:vitexin and derivatives biosynthesis", "PWY-6971:t:oleandomycin biosynthesis", "PWY-5400:t:amaranthin biosynthesis", "PWY-7697:t:geranyl beta-primeveroside biosynthesis"], "type": "Domain"}, "IPR063227": {"description": "RNA exonuclease 3, middle domain", "go_ids": [], "go_terms": [], "name": "REX3_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063228": {"description": "XRRA1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "XRRA1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063230": {"description": "Intimin-like, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_Eae_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063231": {"description": "Ubiquinone biosynthesis accessory factor UbiJ, C-terminal conserved region", "go_ids": [], "go_terms": [], "name": "UbiJ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063232": {"description": "Uncharacterised protein YjzJ", "go_ids": [], "go_terms": [], "name": "YjzJ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063233": {"description": "Defensin-like protein 306, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DF306_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063234": {"description": "ECM9, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ECM9_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063235": {"description": "Mediator complex subunit 17, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Med17_C", "pathway_ids": ["R-HSA-1989781", "R-HSA-9833110", "R-BTA-9841922", "R-DME-9841922", "R-HSA-212436", "R-HSA-9841922", "R-BTA-212436", "R-HSA-381340"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-9833110:r:RSV-host interactions", "R-BTA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-DME-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-212436:r:Generic Transcription Pathway", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-BTA-212436:r:Generic Transcription Pathway", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation"], "type": "Domain"}, "IPR063236": {"description": "Phagocyte signaling-impaired protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Psidin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063237": {"description": "EFM1, middle domain", "go_ids": [], "go_terms": [], "name": "EFM1_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063238": {"description": "Type IVa pilus alignment subcomplex PilO, N-terminal region", "go_ids": [], "go_terms": [], "name": "PilO_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063239": {"description": "Ankyrin repeat and fibronectin type-III domain-containing protein 1-like, middle region", "go_ids": [], "go_terms": [], "name": "ANKFN1-like_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063240": {"description": "Cystathionine gamma-synthase-like, N-terminal", "go_ids": [], "go_terms": [], "name": "Cys_gamma_synth_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063241": {"description": "TFIP11, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TFIP11_C", "pathway_ids": ["R-SSC-72163", "R-HSA-72163", "R-RNO-72163", "R-MMU-72163"], "pathways": ["R-SSC-72163:r:mRNA Splicing - Major Pathway", "R-HSA-72163:r:mRNA Splicing - Major Pathway", "R-RNO-72163:r:mRNA Splicing - Major Pathway", "R-MMU-72163:r:mRNA Splicing - Major Pathway"], "type": "Domain"}, "IPR063242": {"description": "UBR7, C-terminal region", "go_ids": [], "go_terms": [], "name": "UBR7_C", "pathway_ids": ["PWY-7511"], "pathways": ["PWY-7511:t:protein ubiquitination"], "type": "Domain"}, "IPR063243": {"description": "Par-4, SAC region", "go_ids": [], "go_terms": [], "name": "Par-4_SAC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063244": {"description": "DNAJ protein RME-8, PH domain", "go_ids": [], "go_terms": [], "name": "PH_RME-8_2nd", "pathway_ids": ["R-HSA-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR063245": {"description": "FAR1, PH domain", "go_ids": [], "go_terms": [], "name": "PH_FAR1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063246": {"description": "DNA polymerase III delta prime, C-terminal, cyanobacteria", "go_ids": [], "go_terms": [], "name": "DNA_pol3_delp_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063247": {"description": "BcsE, degenerate REC domain", "go_ids": [], "go_terms": [], "name": "REC_BcsE", "pathway_ids": ["R-HSA-9931953"], "pathways": ["R-HSA-9931953:r:Biofilm formation"], "type": "Domain"}, "IPR063248": {"description": "Defensin-like protein 109-like", "go_ids": [], "go_terms": [], "name": "DF109-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063249": {"description": "Interleukin-27 receptor alpha, N-terminal", "go_ids": [], "go_terms": [], "name": "IL27RA_N", "pathway_ids": ["R-MMU-8984722", "R-HSA-8984722", "R-MMU-9020956", "R-HSA-9020956"], "pathways": ["R-MMU-8984722:r:Interleukin-35 Signalling", "R-HSA-8984722:r:Interleukin-35 Signalling", "R-MMU-9020956:r:Interleukin-27 signaling", "R-HSA-9020956:r:Interleukin-27 signaling"], "type": "Domain"}, "IPR063250": {"description": "GPI-anchored protein 45, C-terminal", "go_ids": [], "go_terms": [], "name": "PGA45_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063251": {"description": "Stationary phase-inducible protein CsiE, C-terminal", "go_ids": [], "go_terms": [], "name": "CsiE_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063252": {"description": "E3 ubiquitin-protein ligase UBR4, ubiquitin-like domain", "go_ids": [], "go_terms": [], "name": "UBR4_Ub", "pathway_ids": ["R-DDI-6798695", "R-DDI-983168", "R-HSA-6798695", "R-DME-983168", "R-HSA-9920588", "R-DME-6798695", "R-CEL-6798695", "R-MMU-983168", "R-MMU-6798695", "R-HSA-983168", "R-RNO-983168", "R-CEL-983168", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9920588:r:Dengue virus activates/modulates innate and adaptive immune responses", "R-DME-6798695:r:Neutrophil degranulation", "R-CEL-6798695:r:Neutrophil degranulation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR063253": {"description": "KimA potassium transporter, C-terminal", "go_ids": [], "go_terms": [], "name": "KimA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063254": {"description": "Apolipoprotein B100, beta-belt", "go_ids": [], "go_terms": [], "name": "ApoB100_beta_belt3", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-HSA-8964038", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-RNO-5686938", "R-MMU-3000471", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-HSA-8957275", "R-RNO-3000480", "R-HSA-202733", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964038:r:LDL clearance", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR063255": {"description": "UGO, C-terminal", "go_ids": [], "go_terms": [], "name": "UGO_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063256": {"description": "Probable treble clef zinc finger 2", "go_ids": [], "go_terms": [], "name": "Zf_Tbcl_5_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063258": {"description": "Apolipoprotein B100, beta-belt 2", "go_ids": [], "go_terms": [], "name": "ApoB100_beta_belt2_2", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-HSA-8964038", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-RNO-5686938", "R-MMU-3000471", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-HSA-8957275", "R-RNO-3000480", "R-HSA-202733", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964038:r:LDL clearance", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR063259": {"description": "SPHKAP-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "SPHKAP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063260": {"description": "Baseplate protein PVC11-like", "go_ids": [], "go_terms": [], "name": "PVC11-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063261": {"description": "GMI1, second immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "GMI1_Ig_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063262": {"description": "AAA+ chaperone, second helical domain", "go_ids": [], "go_terms": [], "name": "AAA_chap_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063264": {"description": "Defensin 286/287/288", "go_ids": [], "go_terms": [], "name": "DEFL_286/287/288", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063265": {"description": "Protein OSB1/2/3/4, PDF repeat", "go_ids": [], "go_terms": [], "name": "OSB1/2/3/4_PDF", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063266": {"description": "Protein involved in starch initiation 1, C-terminal coiled coil", "go_ids": [], "go_terms": [], "name": "PII1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063267": {"description": "CASZ1-like, zinc finger 1", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_CASZ1_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063268": {"description": "DnaJ homolog subfamily C member 13, 4th domain", "go_ids": [], "go_terms": [], "name": "RME-8_4th", "pathway_ids": ["R-HSA-6798695"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR063269": {"description": "VviA prenyltransferase", "go_ids": [], "go_terms": [], "name": "VviA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063270": {"description": "Cellulose synthase protein B, second FD domain", "go_ids": [], "go_terms": [], "name": "FD_BcsB_2nd", "pathway_ids": ["R-HSA-9931953"], "pathways": ["R-HSA-9931953:r:Biofilm formation"], "type": "Domain"}, "IPR063273": {"description": "Type IV pili machinery localization factor FimV, N-terminal TPR region", "go_ids": [], "go_terms": [], "name": "TPR_FimV", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063274": {"description": "VPS18, first alpha-solenoid subdomain", "go_ids": [], "go_terms": [], "name": "VPS18_solenoid_1st", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR063275": {"description": "Diptericin A", "go_ids": [], "go_terms": [], "name": "DptA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063276": {"description": "VAB2, coiled coil domain", "go_ids": [], "go_terms": [], "name": "VAB2_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063277": {"description": "Amino acid sensor-independent protein 2", "go_ids": [], "go_terms": [], "name": "ASI2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063279": {"description": "Cytochrome c-type protein TorC/TorY, second domain", "go_ids": [], "go_terms": [], "name": "TorC/TorY_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063280": {"description": "YddI, NTF2-like domain", "go_ids": [], "go_terms": [], "name": "YddI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063281": {"description": "Assembly chaperone of RPL4, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ACL4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063282": {"description": "NLP-40 neuropeptide precursor", "go_ids": [], "go_terms": [], "name": "NLP40", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063283": {"description": "Winged helix-turn-helix domain", "go_ids": [], "go_terms": [], "name": "WHD_NACHT_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063284": {"description": "SHOC1, helix-hairpin-helix tandem 2", "go_ids": [], "go_terms": [], "name": "SHOC1_HhH_tandem_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063285": {"description": "Serine/threonine-protein phosphatase 4 regulatory subunit 1, middle domain", "go_ids": [], "go_terms": [], "name": "PPFR1_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063286": {"description": "PEA2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PEA2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063287": {"description": "Peroxisomal membrane protein PEX17", "go_ids": [], "go_terms": [], "name": "Pex17", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063288": {"description": "Kebab, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Kebab_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063289": {"description": "Uncharacterised protein YfjB, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YfjB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063290": {"description": "Uncharacterised protein y4lR, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Y4lR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063291": {"description": "Trafficking protein particle complex subunit 11, N-terminal domain", "go_ids": [], "go_terms": [], "name": "TRAPPC11_N", "pathway_ids": ["R-HSA-8876198", "R-DRE-8876198", "R-MMU-8876198"], "pathways": ["R-HSA-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-DRE-8876198:r:RAB GEFs exchange GTP for GDP on RABs", "R-MMU-8876198:r:RAB GEFs exchange GTP for GDP on RABs"], "type": "Domain"}, "IPR063293": {"description": "STAG protein, C-terminal domain", "go_ids": [], "go_terms": [], "name": "STAG_C", "pathway_ids": ["R-HSA-2468052", "R-MMU-2500257", "R-HSA-2500257", "R-HSA-2467813", "R-HSA-3108214", "R-MMU-2467813", "R-CEL-2470946", "R-HSA-2470946", "R-HSA-1221632", "R-CEL-3108214", "R-MMU-3108214", "R-CEL-2468052", "R-MMU-2468052", "R-MMU-2470946", "R-HSA-9018519", "R-CEL-2500257"], "pathways": ["R-HSA-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2500257:r:Resolution of Sister Chromatid Cohesion", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-CEL-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-1221632:r:Meiotic synapsis", "R-CEL-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-CEL-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2468052:r:Establishment of Sister Chromatid Cohesion", "R-MMU-2470946:r:Cohesin Loading onto Chromatin", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-CEL-2500257:r:Resolution of Sister Chromatid Cohesion"], "type": "Domain"}, "IPR063294": {"description": "Y4jQ, C-terminal putative histidine kinase domain", "go_ids": [], "go_terms": [], "name": "Y4jQ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063295": {"description": "Fv1, N-terminal region", "go_ids": [], "go_terms": [], "name": "Fv1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063296": {"description": "Infection response protein 2, alpha/beta domain", "go_ids": [], "go_terms": [], "name": "IRG2_ab", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063297": {"description": "MTF1-like, helical domain", "go_ids": [], "go_terms": [], "name": "MTF1_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063298": {"description": "TIM14, N-terminal transmembrane region", "go_ids": [], "go_terms": [], "name": "TIM14_N_euk", "pathway_ids": ["R-HSA-1268020"], "pathways": ["R-HSA-1268020:r:Mitochondrial protein import"], "type": "Domain"}, "IPR063300": {"description": "PEG10/RTL1, C-terminal capsid-like domain", "go_ids": [], "go_terms": [], "name": "PEG10-RTL1_C-capsid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063301": {"description": "SpoVK-like AAA ATPase, N-terminal", "go_ids": [], "go_terms": [], "name": "AAA_SpoVK_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063302": {"description": "SWIFT domain", "go_ids": [], "go_terms": [], "name": "SWIFT", "pathway_ids": ["R-HSA-1989781", "R-DME-9933947", "R-DME-8939243", "R-MMU-9933946", "R-HSA-2151201", "R-DME-9933946", "R-DDI-9933937", "R-RNO-3214858", "R-MMU-9933937", "R-DDI-9933946", "R-CEL-9934037", "R-BTA-9933946", "R-DME-9934037", "R-HSA-1368108", "R-HSA-3214858", "R-RNO-8939243", "R-HSA-9934037", "R-BTA-3214858", "R-DME-9933939", "R-DME-3214858", "R-HSA-9845323", "R-HSA-9933387", "R-HSA-9707564", "R-SPO-9933946", "R-DME-9933937", "R-BTA-9933939", "R-RNO-9933939", "R-CEL-9933946", "R-DDI-9933939", "R-DME-400206", "R-HSA-9931509", "R-RNO-9933946", "R-HSA-2426168", "R-MMU-9934037", "R-CEL-9933947", "R-CEL-9933937", "R-DME-9707564", "R-HSA-381340", "R-HSA-9933947", "R-BTA-9933947", "R-RNO-9934037", "R-DDI-3214858", "R-HSA-9933939", "R-HSA-9707616", "R-RNO-9933947", "R-MMU-3214858", "R-MMU-8939243", "R-HSA-9824585", "R-BTA-9934037", "R-MMU-9933939", "R-HSA-8939243", "R-MMU-9933947", "R-HSA-9933937", "R-CEL-3214858", "R-BTA-8939243", "R-HSA-400206", "R-SPO-9933937", "R-HSA-9933946", "R-CEL-9933939", "R-SPO-9933939", "R-MMU-400206", "R-MMU-9707564", "R-CEL-8939243"], "pathways": ["R-HSA-1989781:r:PPARA activates gene expression", "R-DME-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-DME-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-DME-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DDI-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-RNO-3214858:r:RMTs methylate histone arginines", "R-MMU-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DDI-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-CEL-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-3214858:r:RMTs methylate histone arginines", "R-RNO-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-BTA-3214858:r:RMTs methylate histone arginines", "R-DME-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-DME-3214858:r:RMTs methylate histone arginines", "R-HSA-9845323:r:Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-SPO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DME-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-BTA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-RNO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-CEL-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-DDI-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-DME-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-RNO-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-CEL-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-CEL-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-DME-9707564:r:Cytoprotection by HMOX1", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-HSA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-BTA-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-RNO-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-DDI-3214858:r:RMTs methylate histone arginines", "R-HSA-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9707616:r:Heme signaling", "R-RNO-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-MMU-3214858:r:RMTs methylate histone arginines", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9824585:r:Regulation of MITF-M-dependent genes involved in pigmentation", "R-BTA-9934037:r:Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-MMU-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-MMU-9933947:r:Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-CEL-3214858:r:RMTs methylate histone arginines", "R-BTA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-SPO-9933937:r:Formation of the canonical BAF (cBAF) complex", "R-HSA-9933946:r:Formation of the embryonic stem cell BAF (esBAF) complex", "R-CEL-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-SPO-9933939:r:Formation of the polybromo-BAF (pBAF) complex", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR063303": {"description": "PEX8, C-terminal", "go_ids": [], "go_terms": [], "name": "PEX8_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063304": {"description": "Cancer/testis antigen 55, N-terminal", "go_ids": [], "go_terms": [], "name": "CT55_N", "pathway_ids": ["R-HSA-5601884"], "pathways": ["R-HSA-5601884:r:PIWI-interacting RNA (piRNA) biogenesis"], "type": "Domain"}, "IPR063305": {"description": "Fend, Ig-like domain", "go_ids": [], "go_terms": [], "name": "Fend_Ig-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063306": {"description": "Granulysin domain", "go_ids": [], "go_terms": [], "name": "GNLY", "pathway_ids": ["R-HSA-6803157"], "pathways": ["R-HSA-6803157:r:Antimicrobial peptides"], "type": "Domain"}, "IPR063307": {"description": "F59B10.3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "F59B10_3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063309": {"description": "ATR-interacting protein mus304, C-terminal", "go_ids": [], "go_terms": [], "name": "Mus304_C", "pathway_ids": ["R-DME-176187", "R-DME-69473"], "pathways": ["R-DME-176187:r:Activation of ATR in response to replication stress", "R-DME-69473:r:G2/M DNA damage checkpoint"], "type": "Domain"}, "IPR063310": {"description": "PGAP6/TMEM8, beta-sandwich domain", "go_ids": [], "go_terms": [], "name": "TMEM8_b-sand", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063311": {"description": "Phosphoglycerol transferase I, N-terminal", "go_ids": [], "go_terms": [], "name": "OpgB_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063312": {"description": "F-box protein UCC1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "UCC1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063314": {"description": "RBBP6, linker domain", "go_ids": [], "go_terms": [], "name": "RBBP6_link", "pathway_ids": ["R-SPO-9770562", "R-MMU-9013422", "R-HSA-9013422", "R-HSA-9770562", "R-MMU-9770562", "R-MMU-983168", "R-SPO-983168", "R-SCE-983168", "R-HSA-983168"], "pathways": ["R-SPO-9770562:r:mRNA Polyadenylation", "R-MMU-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9013422:r:RHOBTB1 GTPase cycle", "R-HSA-9770562:r:mRNA Polyadenylation", "R-MMU-9770562:r:mRNA Polyadenylation", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR063315": {"description": "Plant antimicrobial peptide 2", "go_ids": [], "go_terms": [], "name": "Antimicrobial26_2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063316": {"description": "ZSWIM 4/5/6/8, N-terminal helical domain", "go_ids": [], "go_terms": [], "name": "ZSWIM_4/5/6/8_N", "pathway_ids": ["R-HSA-9010553"], "pathways": ["R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs"], "type": "Domain"}, "IPR063317": {"description": "F-box protein SKIP24, C-terminal", "go_ids": [], "go_terms": [], "name": "SKIP24_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063319": {"description": "Uncharacterised protein Rv0964c-like", "go_ids": [], "go_terms": [], "name": "Rv0964c-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063320": {"description": "WIR1 pathogen defence protein", "go_ids": [], "go_terms": [], "name": "WIR1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063321": {"description": "Petuvirus genome polyprotein domain", "go_ids": [], "go_terms": [], "name": "Gen_polyprot_petuvir", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063322": {"description": "Tyrosinase inhibitor domain", "go_ids": [], "go_terms": [], "name": "Tyrosinase_inhib_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063323": {"description": "Regulatory protein ViaA, N-terminal", "go_ids": [], "go_terms": [], "name": "ViaA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063324": {"description": "NELL, C-terminal VWC-associated domain", "go_ids": [], "go_terms": [], "name": "NELL_VWC_C", "pathway_ids": ["R-HSA-428542"], "pathways": ["R-HSA-428542:r:Regulation of commissural axon pathfinding by SLIT and ROBO"], "type": "Domain"}, "IPR063325": {"description": "Uncharacterised protein YhaZ, C-terminal Ig-like domain", "go_ids": [], "go_terms": [], "name": "YhaZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063326": {"description": "GMI1, third immunoglobulin-like domain", "go_ids": [], "go_terms": [], "name": "GMI1_Ig_3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063328": {"description": "Mu-like transposase, middle domain", "go_ids": [], "go_terms": [], "name": "Mu-transpos_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063329": {"description": "Protection of telomeres protein 1, N-terminal OB domain", "go_ids": [], "go_terms": [], "name": "OB_POT1_N", "pathway_ids": ["R-GGA-174417", "R-GGA-174414", "R-GGA-171319", "R-GGA-418124", "R-GGA-174430", "R-GGA-174437", "R-GGA-174411"], "pathways": ["R-GGA-174417:r:Telomere C-strand (Lagging Strand) Synthesis", "R-GGA-174414:r:Processive synthesis on the C-strand of the telomere", "R-GGA-171319:r:Telomere Extension By Telomerase", "R-GGA-418124:r:Telomere maintenance", "R-GGA-174430:r:Telomere C-strand synthesis initiation", "R-GGA-174437:r:Removal of the Flap Intermediate from the C-strand", "R-GGA-174411:r:Polymerase switching on the C-strand of the telomere"], "type": "Domain"}, "IPR063330": {"description": "BUR2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BUR2_C", "pathway_ids": ["R-SCE-9018519", "R-SCE-6807505", "R-SCE-674695", "R-SCE-6796648"], "pathways": ["R-SCE-9018519:r:Estrogen-dependent gene expression", "R-SCE-6807505:r:RNA polymerase II transcribes snRNA genes", "R-SCE-674695:r:RNA Polymerase II Pre-transcription Events", "R-SCE-6796648:r:TP53 Regulates Transcription of DNA Repair Genes"], "type": "Domain"}, "IPR063331": {"description": "ORANGE-like, middle domain", "go_ids": [], "go_terms": [], "name": "Orange-like_mid", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063333": {"description": "Apolipoprotein B100, beta-belt 3", "go_ids": [], "go_terms": [], "name": "ApoB100_beta_belt1_3", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-HSA-8964038", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-RNO-5686938", "R-MMU-3000471", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-HSA-8957275", "R-RNO-3000480", "R-HSA-202733", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-HSA-8964038:r:LDL clearance", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR063334": {"description": "Poly(A)-specific ribonuclease PARN, RNA-recognition domain", "go_ids": [], "go_terms": [], "name": "RRM_PARN_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063335": {"description": "YIL055C, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YIL055C_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063336": {"description": "Uncharacterized protein C16C6.04", "go_ids": [], "go_terms": [], "name": "C16C6_04", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063337": {"description": "Fungal protein FGSG_10745-like", "go_ids": [], "go_terms": [], "name": "FGSG_10745-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063338": {"description": "ATEG_03636-like", "go_ids": [], "go_terms": [], "name": "ATEG_03636-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063339": {"description": "BAG7, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BAG7_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063340": {"description": "CIP7, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CIP7_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063342": {"description": "C45G9.6, N-terminal domain", "go_ids": [], "go_terms": [], "name": "C45G9_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063344": {"description": "F22D3.4-like, N-terminal", "go_ids": [], "go_terms": [], "name": "F22D3_4_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063345": {"description": "Importin beta-like KAP111/KAP122, middle domain", "go_ids": [], "go_terms": [], "name": "KAP111/KAP122_middle", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063346": {"description": "ATRIP, middle domain", "go_ids": [], "go_terms": [], "name": "ATRIP_mid", "pathway_ids": ["R-DME-176187", "R-DME-69473"], "pathways": ["R-DME-176187:r:Activation of ATR in response to replication stress", "R-DME-69473:r:G2/M DNA damage checkpoint"], "type": "Domain"}, "IPR063347": {"description": "Hydrophobin-like protein 1", "go_ids": [], "go_terms": [], "name": "Hydrophobin-like_1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063348": {"description": "Microneme protein 21", "go_ids": [], "go_terms": [], "name": "MIC21", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063349": {"description": "CHAMP1, first C2H2-type zinc finger", "go_ids": [], "go_terms": [], "name": "Znf-C2H2_CHAMP1_1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063350": {"description": "Archaeal bacterial Ig-like domain", "go_ids": [], "go_terms": [], "name": "Archaeal_Big", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063351": {"description": "Putative zinc finger protein C02F5.12, N-terminal", "go_ids": [], "go_terms": [], "name": "C02F5_12_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063352": {"description": "UBR1/2/3-like, ARM repeat domain", 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domain", "go_ids": [], "go_terms": [], "name": "Alg8_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063555": {"description": "Lymphostatin, protease domain", "go_ids": [], "go_terms": [], "name": "Lymphostatin_protease", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063556": {"description": "RNF213, AAA domain 4", "go_ids": [], "go_terms": [], "name": "AAA_RNF213_4", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7250", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7511", "PWY-7887", "PWY-6841", "R-DRE-983168", "R-DDI-983168", "R-HSA-983168", "R-HSA-9725370", "R-HSA-9635465", "R-MMU-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7511:t:protein ubiquitination", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR063557": {"description": "RNF213, stalk domain", "go_ids": [], "go_terms": [], "name": "RNF213_stalk", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7250", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7511", "PWY-7887", "PWY-6841", "R-DRE-983168", "R-HSA-983168", "R-HSA-9725370", "R-HSA-9635465", "R-MMU-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7511:t:protein ubiquitination", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR063558": {"description": "RNF213, AAA domain 3", "go_ids": [], "go_terms": [], "name": "AAA_RNF213_3", "pathway_ids": ["PWY-6682", "PWY-7817", "PWY-6462", "PWY-7250", "PWY-7815", "PWY-6289", "PWY-7816", "PWY-6463", "PWY-7818", "PWY-7511", "PWY-7887", "PWY-6841", "R-DRE-983168", "R-HSA-983168", "R-HSA-9725370", "R-HSA-9635465", "R-MMU-983168"], "pathways": ["PWY-6682:t:dehydrophos biosynthesis", "PWY-7817:t:type I lipoteichoic acid biosynthesis (S. aureus)", "PWY-6462:t:peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)", "PWY-7250:t:[2Fe-2S] iron-sulfur cluster biosynthesis", "PWY-7815:t:poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)", "PWY-6289:t:petrobactin biosynthesis", "PWY-7816:t:poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)", "PWY-6463:t:peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)", "PWY-7818:t:type IV lipoteichoic acid biosynthesis (S. pneumoniae)", "PWY-7511:t:protein ubiquitination", "PWY-7887:t:protein SAMPylation and SAMP-mediated thiolation", "PWY-6841:t:homophytochelatin biosynthesis", "R-DRE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-9725370:r:Signaling by ALK fusions and activated point mutants", "R-HSA-9635465:r:Suppression of apoptosis", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation"], "type": "Domain"}, "IPR063559": {"description": "SHOC1, ATPase domain", "go_ids": [], "go_terms": [], "name": "SHOC1_ATPase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063560": {"description": "SHOC1, PDDEXK domain", "go_ids": [], "go_terms": [], "name": "SHOC1_PDDEXK", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063561": {"description": "Mitochondrial 3' processome subunit 1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MPSS1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063562": {"description": "YBR259W, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YBR259W_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063563": {"description": "DNA repair protein brc-2, C-terminal domain", "go_ids": [], "go_terms": [], "name": "BRC-2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063564": {"description": "DNA repair protein brc-2, N-terminal region", "go_ids": [], "go_terms": [], "name": "BRC-2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063565": {"description": "YAL037W, N-terminal domain", "go_ids": [], "go_terms": [], "name": "YAL037W_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063566": {"description": "C45G9.6, fourth domain", "go_ids": [], "go_terms": [], "name": "C45G9_4th", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063567": {"description": "RSA-1, middle domain", "go_ids": [], "go_terms": [], "name": "RSA-1_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063568": {"description": "RSA-1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RSA-1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063569": {"description": "Coiled-coil domain-containing protein SCD2, C-terminal", "go_ids": [], "go_terms": [], "name": "SCD2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063570": {"description": "At3g27390, C-terminal", "go_ids": [], "go_terms": [], "name": "At3g27390_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063571": {"description": "At3g27390, N-terminal", "go_ids": [], "go_terms": [], "name": "At3g27390_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063572": {"description": "A-kinase anchor protein 11-like, conserved region", "go_ids": [], "go_terms": [], "name": "AKAP11-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063573": {"description": "At1g01500-like, N-terminal", "go_ids": [], "go_terms": [], "name": "At1g01500_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063574": {"description": "Peptide arginase FlmR/OhkR-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FlmR_OhkR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063575": {"description": "DD3-3, cupredoxin-like domain", "go_ids": [], "go_terms": [], "name": "DD3_cupredoxin", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063576": {"description": "DD3-3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DD3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063577": {"description": "DDB_G0287209, N-terminal domain", "go_ids": [], "go_terms": [], "name": "DDB_G0287209_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063578": {"description": "DDB_G0287209, C-terminal domain", "go_ids": [], "go_terms": [], "name": "DDB_G0287209_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063579": {"description": "YibE/F-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YibE_F_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063580": {"description": "Actinomycete integrative conjugative element replication protein domain", "go_ids": [], "go_terms": [], "name": "AICE_RepA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063581": {"description": "Cellulose synthase protein B, second CBM domain", "go_ids": [], "go_terms": [], "name": "CBM_BcsB_2nd", "pathway_ids": ["R-HSA-9931953"], "pathways": ["R-HSA-9931953:r:Biofilm formation"], "type": "Domain"}, "IPR063582": {"description": "OSB1/2/3/4, SSB domain", "go_ids": [], "go_terms": [], "name": "OSB_SSB", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063583": {"description": "Copper resistance protein D-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CopD-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063585": {"description": "US5 assembly chaperone PDCD2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PDCD2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063586": {"description": "NMD3-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NMD3-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063587": {"description": "Fra a 1-associated protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FaAP_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063588": {"description": "Cellulose biosynthesis protein BcsE, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BcsE_N", "pathway_ids": ["R-HSA-9931953"], "pathways": ["R-HSA-9931953:r:Biofilm formation"], "type": "Domain"}, "IPR063589": {"description": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit, WD40 domain", "go_ids": [], "go_terms": [], "name": "TRM82_WD", "pathway_ids": ["R-HSA-6782315"], "pathways": ["R-HSA-6782315:r:tRNA modification in the nucleus and cytosol"], "type": "Domain"}, "IPR063590": {"description": "RAB11-binding protein RELCH, middle HEAT repeats region", "go_ids": [], "go_terms": [], "name": "RELCH_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063591": {"description": "RAB11-binding protein RELCH, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RELCH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063592": {"description": "RELCH, LisH-containing region", "go_ids": [], "go_terms": [], "name": "RELCH_LH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063594": {"description": "Secreted LysM effector LysM4-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "LysM4-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063595": {"description": "HilA/YgeH-like transcriptional regulator, second domain", "go_ids": [], "go_terms": [], "name": "HilA-like_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063596": {"description": "Cilia and flagella-associated protein 70, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CFAP70_TPR_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063597": {"description": "Cilia and flagella-associated protein 70, middle TPR-like domain", "go_ids": [], "go_terms": [], "name": "CFAP70_mid_TPR", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063598": {"description": "Cilia and flagella-associated protein 70, C2 domain", "go_ids": [], "go_terms": [], "name": "CFAP70_C2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063599": {"description": "Defect at low temperature protein 1, C-terminal cytoplasmic domain", "go_ids": [], "go_terms": [], "name": "DLT1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063600": {"description": "Cilia and flagella-associated protein 70, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CFAP70_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063601": {"description": "PTPRO, fifth Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_PTPRO_5th", "pathway_ids": ["R-HSA-9034015"], "pathways": ["R-HSA-9034015:r:Signaling by NTRK3 (TRKC)"], "type": "Domain"}, "IPR063602": {"description": "Indolepyruvate oxidoreductase subunit IorA, second domain", "go_ids": [], "go_terms": [], "name": "IorA_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063603": {"description": "MhpA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "MhpA_C", "pathway_ids": ["PWY-6690"], "pathways": ["PWY-6690:t:cinnamate and 3-hydroxycinnamate degradation to 2-hydroxypentadienoate"], "type": "Domain"}, "IPR063604": {"description": "UPF0489 protein C5orf22 domain", "go_ids": [], "go_terms": [], "name": "C5orf22_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063605": {"description": "McsA, central zinc-finger domain", "go_ids": [], "go_terms": [], "name": "McsA_Znf", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063606": {"description": "Disconnected/basonuclin, C2H2-type zinc finger", "go_ids": [], "go_terms": [], "name": "Znf_C2H2_Disco/BNC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063607": {"description": "SpoIIE, regulatory domain", "go_ids": [], "go_terms": [], "name": "SpoIIE_reg", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063608": {"description": "YpiA-like, C-terminal tetratricopeptide repeats", "go_ids": [], "go_terms": [], "name": "TPR_YpiA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063609": {"description": "NUP42/Amo1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "NUP42/Amo1_N", "pathway_ids": ["R-HSA-180910", "R-SPO-3371453", "R-XTR-4615885", "R-HSA-191859", "R-HSA-3108214", "R-HSA-9705671", "R-SPO-159227", "R-DRE-3232142", "R-SPO-159231", "R-DRE-159231", "R-MMU-3232142", "R-MMU-4570464", "R-DRE-4551638", "R-XTR-159236", "R-HSA-170822", "R-HSA-1169408", "R-DRE-191859", "R-MMU-4615885", "R-HSA-159227", "R-MMU-159230", "R-HSA-159230", "R-HSA-168333", "R-DRE-159236", "R-DRE-3108214", "R-MMU-4085377", "R-HSA-3371453", "R-MMU-4551638", "R-HSA-165054", "R-HSA-4570464", "R-XTR-170822", "R-SPO-4085377", "R-HSA-4615885", "R-HSA-4551638", "R-MMU-191859", "R-MMU-159231", "R-MMU-3371453", "R-HSA-9610379", "R-XTR-191859", "R-HSA-168276", "R-SPO-159236", "R-HSA-168271", "R-HSA-6784531", "R-SPO-4551638", "R-MMU-3301854", "R-XTR-3371453", "R-HSA-4085377", "R-HSA-168325", "R-XTR-4085377", "R-XTR-3301854", "R-HSA-9609690", "R-DRE-3371453", "R-MMU-170822", "R-MMU-159236", "R-HSA-159231", "R-HSA-3232142", "R-HSA-3301854", "R-MMU-159227", "R-SPO-4570464", "R-DRE-3301854", "R-DRE-159227", "R-HSA-5619107", "R-HSA-159236", "R-MMU-3108214", "R-HSA-180746", "R-XTR-3108214"], "pathways": ["R-HSA-180910:r:Vpr-mediated nuclear import of PICs", "R-SPO-3371453:r:Regulation of HSF1-mediated heat shock response", "R-XTR-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-191859:r:snRNP Assembly", "R-HSA-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-SPO-159227:r:Transport of the SLBP independent Mature mRNA", "R-DRE-3232142:r:SUMOylation of ubiquitinylation proteins", "R-SPO-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-DRE-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3232142:r:SUMOylation of ubiquitinylation proteins", "R-MMU-4570464:r:SUMOylation of RNA binding proteins", "R-DRE-4551638:r:SUMOylation of chromatin organization proteins", "R-XTR-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-1169408:r:ISG15 antiviral mechanism", "R-DRE-191859:r:snRNP Assembly", "R-MMU-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-159227:r:Transport of the SLBP independent Mature mRNA", "R-MMU-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-159230:r:Transport of the SLBP Dependant Mature mRNA", "R-HSA-168333:r:NEP/NS2 Interacts with the Cellular Export Machinery", "R-DRE-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-DRE-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-MMU-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-4551638:r:SUMOylation of chromatin organization proteins", "R-HSA-165054:r:Rev-mediated nuclear export of HIV RNA", "R-HSA-4570464:r:SUMOylation of RNA binding proteins", "R-XTR-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-SPO-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-4615885:r:SUMOylation of DNA replication proteins", "R-HSA-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-191859:r:snRNP Assembly", "R-MMU-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-MMU-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-9610379:r:HCMV Late Events", "R-XTR-191859:r:snRNP Assembly", "R-HSA-168276:r:NS1 Mediated Effects on Host Pathways", "R-SPO-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-168271:r:Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-6784531:r:tRNA processing in the nucleus", "R-SPO-4551638:r:SUMOylation of chromatin organization proteins", "R-MMU-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-XTR-3371453:r:Regulation of HSF1-mediated heat shock response", "R-HSA-4085377:r:SUMOylation of SUMOylation proteins", "R-HSA-168325:r:Viral Messenger RNA Synthesis", "R-XTR-4085377:r:SUMOylation of SUMOylation proteins", "R-XTR-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-HSA-9609690:r:HCMV Early Events", "R-DRE-3371453:r:Regulation of HSF1-mediated heat shock response", "R-MMU-170822:r:Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-MMU-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-159231:r:Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-3232142:r:SUMOylation of ubiquitinylation proteins", "R-HSA-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-MMU-159227:r:Transport of the SLBP independent Mature mRNA", "R-SPO-4570464:r:SUMOylation of RNA binding proteins", "R-DRE-3301854:r:Nuclear Pore Complex (NPC) Disassembly", "R-DRE-159227:r:Transport of the SLBP independent Mature mRNA", "R-HSA-5619107:r:Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-159236:r:Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-MMU-3108214:r:SUMOylation of DNA damage response and repair proteins", "R-HSA-180746:r:Nuclear import of Rev protein", "R-XTR-3108214:r:SUMOylation of DNA damage response and repair proteins"], "type": "Domain"}, "IPR063610": {"description": "PEG10/RTL1, protease domain", "go_ids": [], "go_terms": [], "name": "PRO_PEG10-RTL1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063611": {"description": "Vitellogenin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Vitellogenin_N", "pathway_ids": ["R-MMU-8856828", "R-HSA-3000484", "R-MMU-8963888", "R-HSA-3000497", "R-MMU-8964046", "R-RNO-8963901", "R-HSA-8866423", "R-MMU-8856825", "R-HSA-3000480", "R-HSA-8856828", "R-RNO-3000497", "R-HSA-432142", "R-DME-8964041", "R-HSA-8963901", "R-MMU-3000497", "R-RNO-8964026", "R-MMU-3000480", "R-RNO-8964038", "R-MMU-8957275", "R-HSA-8964046", "R-MMU-432142", "R-RNO-3000471", "R-SSC-8964041", "R-MMU-975634", "R-MMU-8866423", "R-HSA-3000471", "R-RNO-8957275", "R-MMU-9707616", "R-MMU-202733", "R-MMU-8964038", "R-MMU-381426", "R-RNO-202733", "R-RNO-8856828", "R-RNO-975634", "R-RNO-9707616", "R-HSA-5686938", "R-RNO-8964046", "R-HSA-381426", "R-HSA-202733", "R-RNO-5686938", "R-SSC-8963888", "R-MMU-3000471", "R-MMU-8964041", "R-RNO-8856825", "R-HSA-8964026", "R-MMU-8964026", "R-HSA-9707616", "R-MMU-5686938", "R-HSA-8963888", "R-HSA-8964041", "R-DRE-8964041", "R-MMU-8963901", "R-RNO-8963888", "R-RNO-381426", "R-HSA-8856825", "R-RNO-8866423", "R-RNO-8964041", "R-HSA-8957275", "R-SSC-8866423", "R-RNO-3000480", "R-HSA-8964038", "R-HSA-975634", "R-RNO-432142"], "pathways": ["R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-3000484:r:Scavenging by Class F Receptors", "R-MMU-8963888:r:Chylomicron assembly", "R-HSA-3000497:r:Scavenging by Class H Receptors", "R-MMU-8964046:r:VLDL clearance", "R-RNO-8963901:r:Chylomicron remodeling", "R-HSA-8866423:r:VLDL assembly", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-3000480:r:Scavenging by Class A Receptors", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-RNO-3000497:r:Scavenging by Class H Receptors", "R-HSA-432142:r:Platelet sensitization by LDL", "R-DME-8964041:r:LDL remodeling", "R-HSA-8963901:r:Chylomicron remodeling", "R-MMU-3000497:r:Scavenging by Class H Receptors", "R-RNO-8964026:r:Chylomicron clearance", "R-MMU-3000480:r:Scavenging by Class A Receptors", "R-RNO-8964038:r:LDL clearance", "R-MMU-8957275:r:Post-translational protein phosphorylation", "R-HSA-8964046:r:VLDL clearance", "R-MMU-432142:r:Platelet sensitization by LDL", "R-RNO-3000471:r:Scavenging by Class B Receptors", "R-SSC-8964041:r:LDL remodeling", "R-MMU-975634:r:Retinoid metabolism and transport", "R-MMU-8866423:r:VLDL assembly", "R-HSA-3000471:r:Scavenging by Class B Receptors", "R-RNO-8957275:r:Post-translational protein phosphorylation", "R-MMU-9707616:r:Heme signaling", "R-MMU-202733:r:Cell surface interactions at the vascular wall", "R-MMU-8964038:r:LDL clearance", "R-MMU-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-RNO-202733:r:Cell surface interactions at the vascular wall", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-975634:r:Retinoid metabolism and transport", "R-RNO-9707616:r:Heme signaling", "R-HSA-5686938:r:Regulation of TLR by endogenous ligand", "R-RNO-8964046:r:VLDL clearance", "R-HSA-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-202733:r:Cell surface interactions at the vascular wall", "R-RNO-5686938:r:Regulation of TLR by endogenous ligand", "R-SSC-8963888:r:Chylomicron assembly", "R-MMU-3000471:r:Scavenging by Class B Receptors", "R-MMU-8964041:r:LDL remodeling", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8964026:r:Chylomicron clearance", "R-MMU-8964026:r:Chylomicron clearance", "R-HSA-9707616:r:Heme signaling", "R-MMU-5686938:r:Regulation of TLR by endogenous ligand", "R-HSA-8963888:r:Chylomicron assembly", "R-HSA-8964041:r:LDL remodeling", "R-DRE-8964041:r:LDL remodeling", "R-MMU-8963901:r:Chylomicron remodeling", "R-RNO-8963888:r:Chylomicron assembly", "R-RNO-381426:r:Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-8866423:r:VLDL assembly", "R-RNO-8964041:r:LDL remodeling", "R-HSA-8957275:r:Post-translational protein phosphorylation", "R-SSC-8866423:r:VLDL assembly", "R-RNO-3000480:r:Scavenging by Class A Receptors", "R-HSA-8964038:r:LDL clearance", "R-HSA-975634:r:Retinoid metabolism and transport", "R-RNO-432142:r:Platelet sensitization by LDL"], "type": "Domain"}, "IPR063612": {"description": "Leucyl/phenylalanyl-tRNA protein transferase, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Leu_Phe_trans_C", "pathway_ids": ["PWY-7801"], "pathways": ["PWY-7801:t:N-end rule pathway I (prokaryotic)"], "type": "Domain"}, "IPR063613": {"description": "Leucyl/phenylalanyl-tRNA protein transferase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Leu_Phe_trans_N", "pathway_ids": ["PWY-7801"], "pathways": ["PWY-7801:t:N-end rule pathway I (prokaryotic)"], "type": "Domain"}, "IPR063614": {"description": "Abl interactor-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "ABI_N", "pathway_ids": ["R-DDI-2029482", "R-HSA-5663213", "R-HSA-9664422", "R-DDI-5663213", "R-RNO-9013149", "R-HSA-2029482", "R-MMU-9013404", "R-MMU-4420097", "R-MMU-2029482", "R-DDI-9013149", "R-RNO-2029482", "R-HSA-9013404", "R-MMU-9013423", "R-HSA-9013423", "R-HSA-9013149", "R-HSA-4420097", "R-MMU-5663213", "R-RNO-5663213", "R-RNO-9013423", "R-DDI-9013423", "R-DDI-9013404", "R-RNO-9013404", "R-MMU-9013149", "R-RNO-4420097"], "pathways": ["R-DDI-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-HSA-9664422:r:FCGR3A-mediated phagocytosis", "R-DDI-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-9013149:r:RAC1 GTPase cycle", "R-HSA-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-MMU-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-RNO-2029482:r:Regulation of actin dynamics for phagocytic cup formation", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-MMU-9013423:r:RAC3 GTPase cycle", "R-HSA-9013423:r:RAC3 GTPase cycle", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-4420097:r:VEGFA-VEGFR2 Pathway", "R-MMU-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-5663213:r:RHO GTPases Activate WASPs and WAVEs", "R-RNO-9013423:r:RAC3 GTPase cycle", "R-DDI-9013423:r:RAC3 GTPase cycle", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-RNO-9013404:r:RAC2 GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-RNO-4420097:r:VEGFA-VEGFR2 Pathway"], "type": "Domain"}, "IPR063615": {"description": "Conditioned medium factor, third Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_CMFA_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063616": {"description": "Anti-sigma-I factor RsgI9, C-terminal domain", "go_ids": [], "go_terms": [], "name": "RsgI9_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063617": {"description": "CdiA, C-terminal tRNase toxin domain", "go_ids": [], "go_terms": [], "name": "CdiA_CT_tRNase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063618": {"description": "tRNA methyltransferase TrmJ, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TrmJ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063619": {"description": "TnsB-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TnsB-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063620": {"description": "Ethanolamine utilisation protein EutQ, C-terminal domain", "go_ids": [], "go_terms": [], "name": "EutQ_cupin_C", "pathway_ids": ["PWY-8086", "PWY-8377", "PWY-5497", "PWY-8303", "PWY-8015", "PWY-5485", "PWY-5482"], "pathways": ["PWY-8086:t:(S)-lactate fermentation to propanoate, acetate and hydrogen", "PWY-8377:t:lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)", "PWY-5497:t:purine nucleobases degradation II (anaerobic)", "PWY-8303:t:reductive glycine pathway of autotrophic CO2 fixation", "PWY-8015:t:glycine degradation (reductive Stickland reaction)", "PWY-5485:t:pyruvate fermentation to acetate IV", "PWY-5482:t:pyruvate fermentation to acetate II"], "type": "Domain"}, "IPR063621": {"description": "Cacna2d1-4/CACHD1, cache middle domain", "go_ids": [], "go_terms": [], "name": "Cacna2d1-4/CACHD1_middle", "pathway_ids": ["R-RNO-422356", "R-MMU-5576893", "R-RNO-5576893", "R-HSA-5576893", "R-HSA-9662360", "R-MMU-422356", "R-RNO-112308", "R-MMU-5576892", "R-HSA-422356", "R-HSA-400042", "R-HSA-9856532", "R-HSA-112308", "R-MMU-112308", "R-HSA-5576892", "R-RNO-5576892"], "pathways": ["R-RNO-422356:r:Regulation of insulin secretion", "R-MMU-5576893:r:Phase 2 - plateau phase", "R-RNO-5576893:r:Phase 2 - plateau phase", "R-HSA-5576893:r:Phase 2 - plateau phase", "R-HSA-9662360:r:Sensory processing of sound by inner hair cells of the cochlea", "R-MMU-422356:r:Regulation of insulin secretion", "R-RNO-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-5576892:r:Phase 0 - rapid depolarisation", "R-HSA-422356:r:Regulation of insulin secretion", "R-HSA-400042:r:Adrenaline,noradrenaline inhibits insulin secretion", "R-HSA-9856532:r:Mechanical load activates signaling by PIEZO1 and integrins in osteocytes", "R-HSA-112308:r:Presynaptic depolarization and calcium channel opening", "R-MMU-112308:r:Presynaptic depolarization and calcium channel opening", "R-HSA-5576892:r:Phase 0 - rapid depolarisation", "R-RNO-5576892:r:Phase 0 - rapid depolarisation"], "type": "Domain"}, "IPR063622": {"description": "N(4)-acetylcytidine amidohydrolase-like, ASCH domain", "go_ids": [], "go_terms": [], "name": "Ac4C_amidohydrolase_ASCH", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063623": {"description": "Regulatory protein PchR, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PchR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063624": {"description": "NUDT19-like, Nudix domain", "go_ids": [], "go_terms": [], "name": "NUDT19-like_Nudix", "pathway_ids": ["PWY-7821", "PWY-7419", "PWY-6383", "PWY-5757", "PWY-6147", "PWY-6797", "PWY-7539", "PWY-7719", "PWY-8289", "PWY-7206", "R-HSA-390918", "R-MMU-390918", "R-RNO-9033241", "R-GGA-390918", "R-CEL-390918", "R-RNO-390918", "R-MMU-9033241", "R-GGA-9033241", "R-HSA-9033241"], "pathways": ["PWY-7821:t:tunicamycin biosynthesis", "PWY-7419:t:FR-900098 and FR-33289 antibiotics biosynthesis", "PWY-6383:t:mono-trans, poly-cis decaprenyl phosphate biosynthesis", "PWY-5757:t:fosfomycin biosynthesis", "PWY-6147:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis I", "PWY-6797:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)", "PWY-7539:t:6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)", "PWY-7719:t:CMP-diacetamido-8-epilegionaminic acid biosynthesis", "PWY-8289:t:dZTP biosynthesis", "PWY-7206:t:pyrimidine deoxyribonucleotides dephosphorylation", "R-HSA-390918:r:Peroxisomal lipid metabolism", "R-MMU-390918:r:Peroxisomal lipid metabolism", "R-RNO-9033241:r:Peroxisomal protein import", "R-GGA-390918:r:Peroxisomal lipid metabolism", "R-CEL-390918:r:Peroxisomal lipid metabolism", "R-RNO-390918:r:Peroxisomal lipid metabolism", "R-MMU-9033241:r:Peroxisomal protein import", "R-GGA-9033241:r:Peroxisomal protein import", "R-HSA-9033241:r:Peroxisomal protein import"], "type": "Domain"}, "IPR063625": {"description": "IbrB-like, C-terminal HTH domain", "go_ids": [], "go_terms": [], "name": "IbrB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063626": {"description": "IS30 transposase, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Tnp_IS30_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063627": {"description": "McdB, C-terminal domain", "go_ids": [], "go_terms": [], "name": "McdB_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063628": {"description": "MCK1-like, N-terminal SAM domain", "go_ids": [], "go_terms": [], "name": "SAM_MCK1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063629": {"description": "Borosin biosynthesis, clasp domain", "go_ids": [], "go_terms": [], "name": "Borosin_clasp", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR063630": {"description": "ZK512.1, Ig-like domain", "go_ids": [], "go_terms": [], "name": "ZK512.1_Ig", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063631": {"description": "Cep290, middle coiled-coil region", "go_ids": [], "go_terms": [], "name": "Cep290_mid_CC", "pathway_ids": ["R-HSA-6798695", "R-HSA-380320", "R-MMU-380259", "R-DRE-6798695", "R-MMU-2565942", "R-MMU-8854518", "R-MMU-6798695", "R-HSA-380284", "R-DRE-380320", "R-MMU-380270", "R-MMU-380284", "R-HSA-380270", "R-HSA-5620912", "R-HSA-380259", "R-HSA-8854518", "R-MMU-5620912", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-DRE-6798695:r:Neutrophil degranulation", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-DRE-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR063632": {"description": "CFAP251, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CFAP251_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063633": {"description": "Transcriptional regulator GadX-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "GadX-like_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063634": {"description": "Countin, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Countin_N", "pathway_ids": ["R-DDI-6798695", "R-DDI-8964038"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-DDI-8964038:r:LDL clearance"], "type": "Domain"}, "IPR063635": {"description": "CABIN1, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CABIN1_N", "pathway_ids": ["R-HSA-2559584", "R-RNO-2559584"], "pathways": ["R-HSA-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-RNO-2559584:r:Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "type": "Domain"}, "IPR063636": {"description": "CABIN1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CABIN1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063637": {"description": "CABIN1, middle domain", "go_ids": [], "go_terms": [], "name": "CABIN1_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063638": {"description": "VPS11-like, beta-propeller domain", "go_ids": [], "go_terms": [], "name": "VPS11_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063639": {"description": "Peroxisomal and mitochondrial division factor 1/2, coiled coil", "go_ids": [], "go_terms": [], "name": "PMD1/2-like_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063640": {"description": "Mercuric transport protein", "go_ids": [], "go_terms": [], "name": "MerT_actino", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063641": {"description": "Astrin, C-terminal", "go_ids": [], "go_terms": [], "name": "Astrin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063642": {"description": "Astrin, middle coiled-coil", "go_ids": [], "go_terms": [], "name": "Astrin_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063643": {"description": "R05D3.9-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "R05D3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063644": {"description": "Sperm-activating peptide, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Speract_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063645": {"description": "CEP83, second coiled-coil", "go_ids": [], "go_terms": [], "name": "CEP83_CC_2nd", "pathway_ids": ["R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912"], "pathways": ["R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-RNO-5620912:r:Anchoring of the basal body to the plasma membrane"], "type": "Domain"}, "IPR063646": {"description": "VOZ, C-terminal domain", "go_ids": ["GO:0043565"], "go_terms": ["GO:0043565:sequence-specific DNA binding:F"], "name": "VOZ_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063647": {"description": "SAGA factor-like TAF6, C-terminal domain", "go_ids": [], "go_terms": [], "name": "Saf6_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063648": {"description": "Transmembrane protein CCDC163", "go_ids": [], "go_terms": [], "name": "CCDC163", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063649": {"description": "Differentiation-associated protein 2 domain", "go_ids": [], "go_terms": [], "name": "DIA2", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063650": {"description": "CEP164, coiled-coil", "go_ids": [], "go_terms": [], "name": "CEP164_CC", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR063651": {"description": "Oxidoreductase YgfK, N-terminal TIM-barrel domain", "go_ids": [], "go_terms": [], "name": "YgfK_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063652": {"description": "Type I restriction enzyme EcoKI endonuclease subunit, second domain", "go_ids": [], "go_terms": [], "name": "T1RK_2nd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063653": {"description": "DNA-binding protein RHL1, conserved domain", "go_ids": [], "go_terms": [], "name": "RHL1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063654": {"description": "Cep290, C-terminal coiled-coil region", "go_ids": [], "go_terms": [], "name": "Cep290_C", "pathway_ids": ["R-DME-6798695"], "pathways": ["R-DME-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR063655": {"description": "TAP1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TAP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063656": {"description": "Claspin, C-terminal", "go_ids": [], "go_terms": [], "name": "Claspin_C", "pathway_ids": ["R-MMU-5689880", "R-DME-111465", "R-HSA-5693607", "R-HSA-5689880", "R-MMU-176187", "R-HSA-111465", "R-MMU-111465", "R-HSA-176187", "R-MMU-5693607", "R-DME-176187"], "pathways": ["R-MMU-5689880:r:Ub-specific processing proteases", "R-DME-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-5693607:r:Processing of DNA double-strand break ends", "R-HSA-5689880:r:Ub-specific processing proteases", "R-MMU-176187:r:Activation of ATR in response to replication stress", "R-HSA-111465:r:Apoptotic cleavage of cellular proteins", "R-MMU-111465:r:Apoptotic cleavage of cellular proteins", "R-HSA-176187:r:Activation of ATR in response to replication stress", "R-MMU-5693607:r:Processing of DNA double-strand break ends", "R-DME-176187:r:Activation of ATR in response to replication stress"], "type": "Domain"}, "IPR063657": {"description": "CXorf58/MFI domain", "go_ids": [], "go_terms": [], "name": "CXorf58_MFI", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063658": {"description": "Thionin-like protein 1/2, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Thionin-like_1/2_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063659": {"description": "K02D10.4-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "K02D10_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063660": {"description": "AGO13/C3H64, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AGO13/C3H64_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063661": {"description": "Conidiation-specific protein Con-13-like domain", "go_ids": [], "go_terms": [], "name": "Con-13", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063662": {"description": "Ceramide phosphoethanolamine synthase", "go_ids": [], "go_terms": [], "name": "CPE_synthase", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063663": {"description": "CLEC16A, helical domain", "go_ids": [], "go_terms": [], "name": "CLEC16A_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063664": {"description": "IPGA1, coiled-coil", "go_ids": [], "go_terms": [], "name": "IPGA1_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063665": {"description": "CCDC148-like, coiled-coil", "go_ids": [], "go_terms": [], "name": "CCDC148-like_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063666": {"description": "STE5, PH domain", "go_ids": [], "go_terms": [], "name": "PH_STE5", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063667": {"description": "Uncharacterized protein B0361.3", "go_ids": [], "go_terms": [], "name": "B0361", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063668": {"description": "DDB_G0284425", "go_ids": [], "go_terms": [], "name": "DDB_G0284425", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063669": {"description": "LSM12, LSM domain, fungi/Trypanosomatids", "go_ids": [], "go_terms": [], "name": "LSM_LSM12_fungi/trypanos", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063670": {"description": "Acetoin catabolism protein X, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AcoX_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063671": {"description": "Peroxisomal LYS1 stabilizing protein 1", "go_ids": [], "go_terms": [], "name": "PLS1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063672": {"description": "Uncharacterised protein TP_0391, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TP_0391_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063673": {"description": "MEDA-4 domain", "go_ids": [], "go_terms": [], "name": "MEDA-4_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063674": {"description": "Phage-like element PBSX protein XkdV-like, 3rd domain", "go_ids": [], "go_terms": [], "name": "XkdV_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063675": {"description": "Uncharacterized protein C35A5.10, N-terminal", "go_ids": [], "go_terms": [], "name": "C35A5_10_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063676": {"description": "TRAPPC10/Trs130, NTS-like domain", "go_ids": [], "go_terms": [], "name": "TRAPPC10-Trs130_NTS", "pathway_ids": ["R-HSA-204005", "R-MMU-204005", "R-DDI-204005", "R-HSA-8876198", "R-MMU-8876198", "R-DDI-8876198", "R-DME-8876198", "R-DME-204005"], "pathways": ["R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-DDI-204005:r:COPII-mediated vesicle transport", "R-HSA-8876198:r:RAB GEFs exchange GTP for GDP 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"go_terms": [], "name": "COR15", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063788": {"description": "Mitosis initiation protein fs(1)Ya, N-terminal zinc finger", "go_ids": [], "go_terms": [], "name": "Fs1Ya_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063789": {"description": "ECU07_1090, N-terminal", "go_ids": [], "go_terms": [], "name": "ECU07_1090_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063790": {"description": "CEP152, first coiled-coil region", "go_ids": [], "go_terms": [], "name": "CEP152_CC1", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR063791": {"description": "Putative malate dehydrogenase 1B, N-terminal", "go_ids": [], "go_terms": [], "name": "MDH1B_N", "pathway_ids": ["PWY-5882", "PWY-5848", "PWY-7045", "PWY-5751", "PWY-7825", "PWY-7788", "PWY-5666", "PWY-8132", "PWY-8426", "PWY-5392", "PWY-6627", "PWY-6946", "PWY-7300", "PWY-6392", "PWY-6945", "PWY-6302", "PWY-8238", "PWY-7948", "PWY-7689", "PWY-8029", "PWY-7321", "PWY-7340", "PWY-7385", "PWY-7440", "PWY-7726", "PWY-5972", "PWY-7692", "PWY-1186", "PWY-8370", "PWY-7489", "PWY-7615", "PWY-7757", "PWY-7337", "PWY-6883", "PWY-7694", "PWY-7693", "PWY-6672", "PWY-7568", "PWY-3162", "PWY-5316", "PWY-5818", "PWY-7787", "PWY-6080", "PWY-7667", "PWY-6926", "PWY-6539", "PWY-5978", "PWY-6634", "PWY-5830", "PWY-8383", "PWY-6322", "PWY-8411", "PWY-7338", "PWY-6704", "PWY-6583", "PWY-8139", "PWY-5652", "PWY-8374", "PWY-7342", "PWY-7774", "PWY-6693", "PWY-7354", "PWY-7531", "PWY-7547", "PWY-6738", "PWY-8012", "PWY-6682", "PWY-7331", "PWY-7104", "PWY-7490", "PWY-6920", "PWY-7811", "PWY-7339", "PWY-735", "PWY-7130", "PWY-7769", "PWY-7657", "PWY-8419", "PWY-5271", "PWY-7734", "PWY-7682", "PWY-7541", "PWY-6626", "PWY-6391", "PWY-6638", "PWY-8152", "PWY-3261", "PWY-8464", "PWY-6733", "PWY-321", "PWY-6637", "PWY-7660", "PWY-6944", "PWY-7288", "PWY-6659", "PWY-7301", "PWY-8367", "PWY-6786", "PWY-6973", "PWY-2541", "PWYG-321", "PWY-5883", "PWY-6053", "PWY-7042", "PWY-7742", "PWY-7621", "PWY-8410", "PWY-5867", "PWY-8214", "PWY-7554", "PWY-8409", "PWY-7814", "PWY-7557", "PWY-8297", "PWY-7403", "PWY-7241", "PWY-6948", "PWY-7610", "PWY-8155", "PWY-6974", "PWY-2601", "PWY-7396", "PWY-7695", "PWY-7304", "PWY-8058", "PWY-8366", "PWY-7043", "PWY-7520", "PWY-6863", "PWY-6976", "PWY-3722", "PWY-7352", "PWY-6989", "PWY-6061", "PWY-8408", "PWY-7649", "PWY-8397", "PWY-7613", "PWY-5782", "PWY-741", "PWY-7333", "PWY-5101", "PWY-7775", "PWY-1121", "PWY-7606", "PWY-7741", "PWY-7779"], "pathways": ["PWY-5882:t:epoxypseudoisoeugenol-2-methylbutanoate biosynthesis", "PWY-5848:t:cinchona alkaloids biosynthesis", "PWY-7045:t:mithramycin biosynthesis", "PWY-5751:t:phenylethanol biosynthesis", "PWY-7825:t:juglone degradation", "PWY-7788:t:erythritol degradation II", "PWY-5666:t:alpha-solanine/alpha-chaconine biosynthesis", "PWY-8132:t:S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-5392:t:reductive TCA cycle II", "PWY-6627:t:salinosporamide A biosynthesis", "PWY-6946:t:cholesterol degradation to androstenedione II (cholesterol dehydrogenase)", "PWY-7300:t:ecdysone and 20-hydroxyecdysone biosynthesis", "PWY-6392:t:meso-butanediol biosynthesis II", "PWY-6945:t:cholesterol degradation to androstenedione I (cholesterol oxidase)", "PWY-6302:t:dihydroconiferyl alcohol biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7948:t:4-oxopentanoate degradation", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-8029:t:limonene degradation IV (anaerobic)", "PWY-7321:t:ecdysteroid metabolism (arthropods)", "PWY-7340:t:9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)", "PWY-7385:t:1,3-propanediol biosynthesis (engineered)", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-7726:t:(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)", "PWY-5972:t:stearate biosynthesis I (animals)", "PWY-7692:t:bikaverin biosynthesis", "PWY-1186:t:L-homomethionine biosynthesis", "PWY-8370:t:leporin B biosynthesis", "PWY-7489:t:oryzalexin A, B, and C biosynthesis", "PWY-7615:t:pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)", "PWY-7757:t:bisphenol A degradation", "PWY-7337:t:10-cis-heptadecenoyl-CoA degradation (yeast)", "PWY-6883:t:pyruvate fermentation to butanol II (engineered)", "PWY-7694:t:zwittermicin A biosynthesis", "PWY-7693:t:guadinomine B biosynthesis", "PWY-6672:t:cis-geranyl-CoA degradation", "PWY-7568:t:L-galactose degradation", "PWY-3162:t:L-tryptophan degradation V (side chain pathway)", "PWY-5316:t:nicotine biosynthesis", "PWY-5818:t:validamycin biosynthesis", "PWY-7787:t:L-threitol degradation", "PWY-6080:t:4-ethylphenol degradation (anaerobic)", "PWY-7667:t:apicidin biosynthesis", "PWY-6926:t:pyrethrin I biosynthesis", "PWY-6539:t:(Z)-phenylmethanethial S-oxide biosynthesis", "PWY-5978:t:kanosamine biosynthesis I", "PWY-6634:t:3-sulfopropanediol degradation I", "PWY-5830:t:CDP-ascarylose biosynthesis", "PWY-8383:t:myxochelin A and B biosynthesis", "PWY-6322:t:phosphinothricin tripeptide biosynthesis", "PWY-8411:t:representative whole plasma arachidonate-derived icosanoids II", "PWY-7338:t:10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)", "PWY-6704:t:L-ascorbate degradation IV", "PWY-6583:t:pyruvate fermentation to butanol I", "PWY-8139:t:CDP-6-deoxy-D-gulose biosynthesis", "PWY-5652:t:2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA", "PWY-8374:t:antimycin biosynthesis", "PWY-7342:t:superpathway of nicotine biosynthesis", "PWY-7774:t:propane degradation I", "PWY-6693:t:D-galactose degradation IV", "PWY-7354:t:aclacinomycin biosynthesis", "PWY-7531:t:mannojirimycin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-6738:t:pinitol biosynthesis I", "PWY-8012:t:mupirocin biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-7331:t:UDP-N-acetyl-beta-L-quinovosamine biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7490:t:patulin biosynthesis", "PWY-6920:t:6-gingerol analog biosynthesis (engineered)", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7339:t:10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)", "PWY-735:t:jasmonic acid biosynthesis", "PWY-7130:t:L-glucose degradation", "PWY-7769:t:phosalacine biosynthesis", "PWY-7657:t:dTDP-beta-L-digitoxose biosynthesis", "PWY-8419:t:L-canavanine degradation II", "PWY-5271:t:abscisic acid degradation to phaseic acid", "PWY-7734:t:quinoxaline-2-carboxylate biosynthesis", "PWY-7682:t:arabidopyrone biosynthesis", "PWY-7541:t:1,2-propanediol biosynthesis from lactate (engineered)", "PWY-6626:t:cytidine-5'-diphosphate-glycerol biosynthesis", "PWY-6391:t:meso-butanediol biosynthesis I", "PWY-6638:t:sulfolactate degradation III", "PWY-8152:t:androstenedione degradation II (anaerobic)", "PWY-3261:t:UDP-beta-L-rhamnose biosynthesis", "PWY-8464:t:sphingofungin B-D biosynthesis", "PWY-6733:t:sporopollenin precursors biosynthesis", "PWY-321:t:cutin biosynthesis", "PWY-6637:t:sulfolactate degradation II", "PWY-7660:t:tryptoquialanine biosynthesis", "PWY-6944:t:androstenedione degradation I (aerobic)", "PWY-7288:t:fatty acid beta-oxidation VII (yeast peroxisome)", "PWY-6659:t:fusicoccin A biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-6786:t:detoxification of reactive carbonyls in chloroplasts", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWY-2541:t:phytosterol biosynthesis (plants)", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-6053:t:dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)", "PWY-7042:t:the visual cycle (insects)", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-7621:t:autoinducer CAI-1 biosynthesis", "PWY-8410:t:representative whole plasma arachidonate-derived icosanoids I", "PWY-5867:t:t-anethole biosynthesis", "PWY-8214:t:3-sulfopropanediol degradation II", "PWY-7554:t:heme d1 biosynthesis", "PWY-8409:t:cyathin biosynthesis", "PWY-7814:t:dTDP-L-daunosamine biosynthesis", "PWY-7557:t:(-)-dehydrodiconiferyl alcohol degradation", "PWY-8297:t:6-diazo-5-oxo-L-norleucine biosynthesis", "PWY-7403:t:tetramethylpyrazine degradation", "PWY-7241:t:myo-inositol degradation II", "PWY-6948:t:sitosterol degradation to androstenedione", "PWY-7610:t:GDP-6-deoxy-D-altro-heptose biosynthesis", "PWY-8155:t:testosterone degradation (anaerobic)", "PWY-6974:t:dTDP-beta-L-olivose biosynthesis", "PWY-2601:t:isethionate degradation", "PWY-7396:t:butanol and isobutanol biosynthesis (engineered)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-7304:t:3-amino-4,7-dihydroxy-coumarin biosynthesis", "PWY-8058:t:2-deoxy-D-ribose degradation II", "PWY-8366:t:septacidin biosynthesis", "PWY-7043:t:11-cis-3-hydroxyretinal biosynthesis", "PWY-7520:t:terrequinone A biosynthesis", "PWY-6863:t:pyruvate fermentation to hexanol (engineered)", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-3722:t:glycine betaine biosynthesis II (Gram-positive bacteria)", "PWY-7352:t:daunorubicin biosynthesis", "PWY-6989:t:(S)-camphor degradation", "PWY-6061:t:bile acid biosynthesis, neutral pathway", "PWY-8408:t:erinacine biosynthesis", "PWY-7649:t:3-hydroxy-L-homotyrosine biosynthesis", "PWY-8397:t:arachidonate metabolites biosynthesis", "PWY-7613:t:GDP-6-deoxy-D-manno-heptose biosynthesis", "PWY-5782:t:2-keto-L-gulonate biosynthesis", "PWY-741:t:p-cymene degradation to p-cumate", "PWY-7333:t:UDP-N-acetyl-alpha-D-fucosamine biosynthesis", "PWY-5101:t:L-isoleucine biosynthesis II", "PWY-7775:t:propane degradation II", "PWY-1121:t:suberin monomers biosynthesis", "PWY-7606:t:docosahexaenoate biosynthesis III (6-desaturase, mammals)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-7779:t:methyl tert-butyl ether degradation"], "type": "Domain"}, "IPR063792": {"description": "Defensin-like protein 78/80, conserved domain", "go_ids": [], "go_terms": [], "name": "DEF78-80_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063793": {"description": "ZK652.8", "go_ids": [], "go_terms": [], "name": "ZK652", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063794": {"description": "Apicomplexa microprotein 35", "go_ids": [], "go_terms": [], "name": "Microp_apicomplexa_35", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063795": {"description": "Schlafen-like domain, nematodes", "go_ids": [], "go_terms": [], "name": "SLFN_nematode", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063796": {"description": "Protein of unknown function DUF8643", "go_ids": [], "go_terms": [], "name": "DUF8643", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063797": {"description": "Coiled-coil domain-containing protein 110, coiled coil domain", "go_ids": [], "go_terms": [], "name": "CCDC110_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063798": {"description": "ENTR1, coiled coil region", "go_ids": [], "go_terms": [], "name": "ENTR1_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063799": {"description": "EGAP4-like, conserved domain", "go_ids": [], "go_terms": [], "name": "EGAP4_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063800": {"description": "Autotransporter YaiT, N-terminal passenger domain", "go_ids": [], "go_terms": [], "name": "YaiT_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063801": {"description": "NDH complex assembly factor CRR9", "go_ids": [], "go_terms": [], "name": "CRR9", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063802": {"description": "Little elongation complex subunit 1, C-terminal, insects", "go_ids": [], "go_terms": [], "name": "Ice1_insects_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063803": {"description": "Mycolysin-like, C-terminal", "go_ids": [], "go_terms": [], "name": "Mycolysin_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063804": {"description": "Glutamine/asparagine-rich protein mdt-30", "go_ids": [], "go_terms": [], "name": "Mdt30", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063805": {"description": "Ubiquitin-conjugating enzyme suppressor 1, N-terminal", "go_ids": [], "go_terms": [], "name": "UBS1_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063806": {"description": "Par, wHTH", "go_ids": [], "go_terms": [], "name": "wHTH_Par", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063807": {"description": "5-methylcytosine-modifying enzyme 1, C-terminal", "go_ids": [], "go_terms": [], "name": "CMD1_TET_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063808": {"description": "Protein PIGMENT DEFECTIVE 338, N-terminal S1 domain", "go_ids": [], "go_terms": [], "name": "PD338_S1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063809": {"description": "OsI_030282-like, C-terminal", "go_ids": [], "go_terms": [], "name": "OsI_030282_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063810": {"description": "NF-kappa-B inhibitor-like protein 1, C-terminal", "go_ids": [], "go_terms": [], "name": "NFKBIL1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063811": {"description": "BamM, C-terminal", "go_ids": [], "go_terms": [], "name": "BamM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063812": {"description": "YMR187C, C-terminal", "go_ids": [], "go_terms": [], "name": "YMR187C_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063813": {"description": "CCDC146, N-terminal coiled-coil region", "go_ids": [], "go_terms": [], "name": "CCDC146_CC_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063814": {"description": "CCDC146, C-terminal coiled-coil domain", "go_ids": [], "go_terms": [], "name": "CCDC146_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063815": {"description": "Agglutinin-like protein, middle domain", "go_ids": [], "go_terms": [], "name": "ALS_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063816": {"description": "CS5 region protein, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CS5_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063817": {"description": "TP013X-like lipoprotein", "go_ids": [], "go_terms": [], "name": "TP013X", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR063818": {"description": "Tbc2 translation factor, C-terminal", "go_ids": [], "go_terms": [], "name": "TBC2_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063819": {"description": "PID-3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "PID3_N", 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"R-MMU-9013408", "R-HSA-9013106", "R-HSA-9013424", "R-MMU-9013404", "R-DDI-5626467", "R-DDI-9013149", "R-SPO-9013106", "R-SPO-9013406", "R-MMU-9013420", "R-HSA-6802946", "R-HSA-9649948", "R-HSA-9013148", "R-SPO-9013420", "R-HSA-9013408", "R-HSA-6802955", "R-SPO-5626467", "R-HSA-373753", "R-DDI-6798695", "R-HSA-9013420", "R-HSA-6802948", "R-MMU-5626467", "R-MMU-9013424", "R-HSA-9013404", "R-SPO-8980692", "R-MMU-373753", "R-HSA-9013149", "R-HSA-8980692", "R-DDI-5674135", "R-HSA-381676", "R-MMU-9013406", "R-SPO-9013424", "R-HSA-9013026", "R-MMU-6798695", "R-DDI-9013404", "R-HSA-9013406", "R-MMU-9013149", "R-HSA-9656223"], "pathways": ["R-HSA-6798695:r:Neutrophil degranulation", "R-HSA-9013409:r:RHOJ GTPase cycle", "R-SPO-6798695:r:Neutrophil degranulation", "R-HSA-5674135:r:MAP2K and MAPK activation", "R-MMU-5674135:r:MAP2K and MAPK activation", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions", "R-HSA-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-9013106:r:RHOC GTPase cycle", "R-MMU-8980692:r:RHOA GTPase cycle", "R-MMU-9013408:r:RHOG GTPase cycle", "R-HSA-9013106:r:RHOC GTPase cycle", "R-HSA-9013424:r:RHOV GTPase cycle", "R-MMU-9013404:r:RAC2 GTPase cycle", "R-DDI-5626467:r:RHO GTPases activate IQGAPs", "R-DDI-9013149:r:RAC1 GTPase cycle", "R-SPO-9013106:r:RHOC GTPase cycle", "R-SPO-9013406:r:RHOQ GTPase cycle", "R-MMU-9013420:r:RHOU GTPase cycle", "R-HSA-6802946:r:Signaling by moderate kinase activity BRAF mutants", "R-HSA-9649948:r:Signaling downstream of RAS mutants", "R-HSA-9013148:r:CDC42 GTPase cycle", "R-SPO-9013420:r:RHOU GTPase cycle", "R-HSA-9013408:r:RHOG GTPase cycle", "R-HSA-6802955:r:Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-SPO-5626467:r:RHO GTPases activate IQGAPs", "R-HSA-373753:r:Nephrin family interactions", "R-DDI-6798695:r:Neutrophil degranulation", "R-HSA-9013420:r:RHOU GTPase cycle", "R-HSA-6802948:r:Signaling by high-kinase activity BRAF mutants", "R-MMU-5626467:r:RHO GTPases activate IQGAPs", "R-MMU-9013424:r:RHOV GTPase cycle", "R-HSA-9013404:r:RAC2 GTPase cycle", "R-SPO-8980692:r:RHOA GTPase cycle", "R-MMU-373753:r:Nephrin family interactions", "R-HSA-9013149:r:RAC1 GTPase cycle", "R-HSA-8980692:r:RHOA GTPase cycle", "R-DDI-5674135:r:MAP2K and MAPK activation", "R-HSA-381676:r:Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "R-MMU-9013406:r:RHOQ GTPase cycle", "R-SPO-9013424:r:RHOV GTPase cycle", "R-HSA-9013026:r:RHOB GTPase cycle", "R-MMU-6798695:r:Neutrophil degranulation", "R-DDI-9013404:r:RAC2 GTPase cycle", "R-HSA-9013406:r:RHOQ GTPase cycle", "R-MMU-9013149:r:RAC1 GTPase cycle", "R-HSA-9656223:r:Signaling by RAF1 mutants"], "type": "Domain"}, "IPR063992": {"description": "Surface glycan-binding protein BT_1761, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BT_1761_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063993": {"description": "Arginine N-succinyltransferase beta subunit, C-terminal domain", "go_ids": [], "go_terms": [], "name": "AstA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063994": {"description": "Flagellar biosynthesis protein FlhF, helical domain", "go_ids": [], "go_terms": [], "name": "FlhF_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063997": {"description": "PhiA-like secreted protein domain", "go_ids": [], "go_terms": [], "name": "PhiA_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR063999": {"description": "NfeD, C-terminal domain", "go_ids": [], "go_terms": [], "name": "NfeD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064000": {"description": "YIPF3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YIPF3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064001": {"description": "SSP120-like, EF-hand pair", "go_ids": [], "go_terms": [], "name": "EF_SSP120", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064002": {"description": "BamG", "go_ids": [], "go_terms": [], "name": "BamG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064003": {"description": "Protein PHLOEM PROTEIN 2-LIKE A10", "go_ids": [], "go_terms": [], "name": "PP2-like-A10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064004": {"description": "GerT, C-terminal domain", "go_ids": [], "go_terms": [], "name": "GerT_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064005": {"description": "R9BP, syntaxin-like domain", "go_ids": [], "go_terms": [], "name": "Syntaxin_R9BP", "pathway_ids": ["R-HSA-2514859", "R-MMU-2514859", "R-BTA-2514859"], "pathways": ["R-HSA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-MMU-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade", "R-BTA-2514859:r:Inactivation, recovery and regulation of the phototransduction cascade"], "type": "Domain"}, "IPR064006": {"description": "CEP164, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CEP164_N", "pathway_ids": ["R-HSA-380320", "R-MMU-380259", "R-MMU-8854518", "R-HSA-5620912", "R-MMU-380270", "R-HSA-380284", "R-MMU-5620912", "R-HSA-380270", "R-HSA-380259", "R-MMU-380284", "R-MMU-2565942", "R-HSA-8854518", "R-MMU-380320", "R-HSA-2565942"], "pathways": ["R-HSA-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-MMU-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-8854518:r:AURKA Activation by TPX2", "R-HSA-5620912:r:Anchoring of the basal body to the plasma membrane", "R-MMU-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-5620912:r:Anchoring of the basal body to the plasma membrane", "R-HSA-380270:r:Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380259:r:Loss of Nlp from mitotic centrosomes", "R-MMU-380284:r:Loss of proteins required for interphase microtubule organization from the centrosome", "R-MMU-2565942:r:Regulation of PLK1 Activity at G2/M Transition", "R-HSA-8854518:r:AURKA Activation by TPX2", "R-MMU-380320:r:Recruitment of NuMA to mitotic centrosomes", "R-HSA-2565942:r:Regulation of PLK1 Activity at G2/M Transition"], "type": "Domain"}, "IPR064007": {"description": "Phylloplanin", "go_ids": [], "go_terms": [], "name": "Phylloplanin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064008": {"description": "Variant surface glycoprotein 20-like, C-terminal", "go_ids": [], "go_terms": [], "name": "VSG20-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064009": {"description": "Outer membrane protein assembly factor BamC-like, N-terminal domain", "go_ids": [], "go_terms": [], "name": "BamC-like_N", "pathway_ids": ["R-HSA-9760173"], "pathways": ["R-HSA-9760173:r:Secretion of toxins"], "type": "Domain"}, "IPR064010": {"description": "Vacuolating cytotoxin autotransporter VacA, C-terminal domain", "go_ids": [], "go_terms": [], "name": "VacA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064011": {"description": "R3HCC1L-like, RNA-recognition domain", "go_ids": [], "go_terms": [], "name": "RRM_R3HCC1L", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064012": {"description": "APC1, fifth domain", "go_ids": [], "go_terms": [], "name": "APC1_5th", "pathway_ids": ["R-HSA-8853884", "R-HSA-174178", "R-SPO-176408", "R-HSA-2467813", "R-MMU-2467813", "R-MMU-174154", "R-MMU-179409", "R-MMU-69017", "R-HSA-2559582", "R-HSA-174184", "R-MMU-174178", "R-CEL-983168", "R-MMU-174048", "R-DDI-179409", "R-HSA-141430", "R-DDI-176409", "R-DDI-2559582", "R-DDI-2467813", "R-SPO-983168", "R-DDI-176412", "R-SCE-983168", "R-DDI-176407", "R-HSA-174084", "R-HSA-176407", "R-MMU-174084", "R-HSA-176408", "R-DDI-69017", "R-HSA-68867", "R-HSA-176412", "R-MMU-176408", "R-MMU-68867", "R-MMU-176409", "R-DDI-174084", "R-HSA-176409", "R-SPO-2559582", "R-HSA-9687136", "R-HSA-174154", "R-MMU-2559582", "R-HSA-983168", "R-SPO-179409", "R-DDI-174048", "R-MMU-176412", "R-MMU-176407", "R-DDI-983168", "R-MMU-174184", "R-MMU-141430", "R-DDI-174184", "R-HSA-69017", "R-DDI-141430", "R-MMU-983168", "R-HSA-174048", "R-HSA-179409", "R-DDI-174178", "R-DDI-174154", "R-DDI-176408"], "pathways": ["R-HSA-8853884:r:Transcriptional Regulation by VENTX", "R-HSA-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-SPO-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-2467813:r:Separation of Sister Chromatids", "R-MMU-2467813:r:Separation of Sister Chromatids", "R-MMU-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-MMU-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-CEL-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-DDI-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-HSA-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-DDI-2467813:r:Separation of Sister Chromatids", "R-SPO-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176412:r:Phosphorylation of the APC/C", "R-SCE-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-DDI-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-HSA-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-MMU-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-DDI-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-68867:r:Assembly of the pre-replicative complex", "R-HSA-176412:r:Phosphorylation of the APC/C", "R-MMU-176408:r:Regulation of APC/C activators between G1/S and early anaphase", "R-MMU-68867:r:Assembly of the pre-replicative complex", "R-MMU-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-DDI-174084:r:Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-176409:r:APC/C:Cdc20 mediated degradation of mitotic proteins", "R-SPO-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-9687136:r:Aberrant regulation of mitotic exit in cancer due to RB1 defects", "R-HSA-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-MMU-2559582:r:Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-SPO-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-MMU-176412:r:Phosphorylation of the APC/C", "R-MMU-176407:r:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "R-DDI-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-MMU-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-MMU-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-DDI-174184:r:Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-69017:r:CDK-mediated phosphorylation and removal of Cdc6", "R-DDI-141430:r:Inactivation of APC/C via direct inhibition of the APC/C complex", "R-MMU-983168:r:Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-174048:r:APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-179409:r:APC-Cdc20 mediated degradation of Nek2A", "R-DDI-174178:r:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-DDI-174154:r:APC/C:Cdc20 mediated degradation of Securin", "R-DDI-176408:r:Regulation of APC/C activators between G1/S and early anaphase"], "type": "Domain"}, "IPR064013": {"description": "Rv0959-like protein, vWA domain", "go_ids": [], "go_terms": [], "name": "vWA_Rv0959", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064014": {"description": "MHP1/HER1/GIP3, LRR domain", "go_ids": [], "go_terms": [], "name": "LRR_MHP1-HER1-GIP3", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064015": {"description": "Armadillo repeat-containing protein wrm-1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "WRM1_C", "pathway_ids": ["R-CEL-9013407", "R-CEL-9013406", "R-CEL-6809371", "R-CEL-8980692", "R-CEL-5218920", "R-CEL-9764561", "R-CEL-6798695"], "pathways": ["R-CEL-9013407:r:RHOH GTPase cycle", "R-CEL-9013406:r:RHOQ GTPase cycle", "R-CEL-6809371:r:Formation of the cornified envelope", "R-CEL-8980692:r:RHOA GTPase cycle", "R-CEL-5218920:r:VEGFR2 mediated vascular permeability", "R-CEL-9764561:r:Regulation of CDH1 Function", "R-CEL-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR064016": {"description": "LIP1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LIP1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064018": {"description": "C-type lectin domain-containing protein 141/158", "go_ids": [], "go_terms": [], "name": "Clec-141-158", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064019": {"description": "VPS35L, C-terminal domain", "go_ids": [], "go_terms": [], "name": "VPS35L_C", "pathway_ids": ["R-DDI-6798695", "R-MMU-6798695", "R-HSA-6798695", "R-DME-6798695", "R-DRE-6798695", "R-RNO-6798695"], "pathways": ["R-DDI-6798695:r:Neutrophil degranulation", "R-MMU-6798695:r:Neutrophil degranulation", "R-HSA-6798695:r:Neutrophil degranulation", "R-DME-6798695:r:Neutrophil degranulation", "R-DRE-6798695:r:Neutrophil degranulation", "R-RNO-6798695:r:Neutrophil degranulation"], "type": "Domain"}, "IPR064020": {"description": "Phage L-alanyl-D-glutamate peptidase", "go_ids": [], "go_terms": [], "name": "Lys_phage", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064021": {"description": "SHORT HYPOCOTYL IN WHITE LIGHT 1, helical domain", "go_ids": [], "go_terms": [], "name": "SHW1_helical", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064022": {"description": "YDL157C", "go_ids": [], "go_terms": [], "name": "YDL157C", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064023": {"description": "Avian coronavirus HKU16-like accessory protein NS7a, Deltacoronavirus", "go_ids": [], "go_terms": [], "name": "NS7a_deltaCoV_HKU16-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064024": {"description": "PROHORMONE-4-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PROH4-like_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064025": {"description": "Exophilin-5, N-terminal domain", "go_ids": [], "go_terms": [], "name": "Exophilin5_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064026": {"description": "CFA/I fimbrial subunit E, N-terminal domain", "go_ids": [], "go_terms": [], "name": "CfaE_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064027": {"description": "YycH, C-terminal domain", "go_ids": [], "go_terms": [], "name": "YycH_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064028": {"description": "NLRC4, LRR domain", "go_ids": [], "go_terms": [], "name": "LRR_NLRC4", "pathway_ids": ["R-HSA-6803207", "R-HSA-844623"], "pathways": ["R-HSA-6803207:r:TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-844623:r:The IPAF inflammasome"], "type": "Domain"}, "IPR064029": {"description": "Chondroitin proteoglycan 3, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CPG3_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064030": {"description": "Dihydromethanophenazine:CoB--CoM heterodisulfide reductase subunit E", "go_ids": [], "go_terms": [], "name": "HdrE", "pathway_ids": ["PWY-5207"], "pathways": ["PWY-5207:t:coenzyme B/coenzyme M regeneration I (methanophenazine-dependent)"], "type": "Domain"}, "IPR064031": {"description": "CARMIL-like, LRR domain", "go_ids": [], "go_terms": [], "name": "LRR_CARMIL", "pathway_ids": ["R-HSA-983231"], "pathways": ["R-HSA-983231:r:Factors involved in megakaryocyte development and platelet production"], "type": "Domain"}, "IPR064032": {"description": "Transcriptional regulator RcsA, N-terminal dimerisation domain", "go_ids": [], "go_terms": [], "name": "RcsA_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064033": {"description": "Inhibitor of nuclear factor kappa-B kinase, UBL domain", "go_ids": [], "go_terms": [], "name": "UBL_IKK", "pathway_ids": ["R-BTA-9909505", "R-MMU-9909505", "R-HSA-9020702", "R-RNO-9758274", "R-DRE-1169091", "R-RNO-9020702", "R-HSA-168638", "R-MMU-5607764", "R-HSA-9833482", "R-XTR-5357905", "R-XTR-5607764", "R-MMU-198323", "R-BTA-202424", "R-MMU-9020702", "R-XTR-202424", "R-HSA-5676590", "R-BTA-975144", "R-RNO-5357905", "R-MMU-933542", "R-DRE-198323", "R-DRE-445989", "R-MMU-9833482", "R-HSA-5684264", "R-MMU-445989", "R-BTA-9758274", "R-HSA-168927", "R-BTA-1169091", "R-XTR-5607761", "R-MMU-1810476", "R-BTA-937041", "R-RNO-202424", "R-HSA-937041", "R-DRE-9020702", "R-BTA-5607761", "R-GGA-1227892", "R-MMU-5684264", "R-HSA-5603029", "R-HSA-5607761", "R-MMU-975144", "R-XTR-5684264", "R-HSA-209560", "R-BTA-5357905", "R-MMU-209543", "R-HSA-975144", "R-HSA-5674400", "R-RNO-975144", "R-RNO-209560", "R-HSA-9758274", "R-GGA-434131", "R-BTA-5684264", "R-MMU-9860276", "R-HSA-5602636", "R-RNO-209543", "R-HSA-9860276", "R-HSA-1169091", "R-DRE-5357905", "R-DRE-5684264", "R-BTA-1810476", "R-MMU-2871837", "R-BTA-933542", "R-MMU-5357905", "R-RNO-445989", "R-HSA-1236974", "R-DRE-5607761", "R-HSA-9860927", "R-BTA-937039", "R-BTA-9833482", "R-DRE-937039", "R-MMU-9860927", "R-RNO-933542", "R-HSA-445989", "R-HSA-9705671", "R-RNO-9860276", "R-BTA-5357956", "R-RNO-9833482", "R-HSA-209543", "R-HSA-933542", "R-RNO-9909505", "R-MMU-5357956", "R-BTA-5676590", "R-DRE-9833482", "R-HSA-9909505", "R-HSA-198323", "R-RNO-9860927", "R-HSA-2871837", "R-BTA-2871837", "R-HSA-5357905", "R-MMU-937039", "R-BTA-209543", "R-BTA-445989", "R-DRE-5676590", "R-XTR-445989", "R-HSA-5607764", "R-BTA-209560", "R-XTR-9758274", "R-RNO-1810476", "R-MMU-202424", "R-RNO-937039", "R-RNO-937041", "R-XTR-2871837", "R-GGA-1227739", "R-RNO-2871837", "R-MMU-209560", "R-RNO-5684264", "R-BTA-9860276", "R-MMU-1169091", "R-GGA-434001", "R-MMU-5607761", "R-MMU-5676590", "R-HSA-1810476", "R-BTA-9860927", "R-XTR-9833482", "R-HSA-5603027", "R-DRE-975144", "R-HSA-5357956", "R-RNO-5607764", "R-RNO-1169091", "R-HSA-933543", "R-BTA-9020702", "R-BTA-5607764", "R-RNO-5357956", "R-MMU-9758274", "R-HSA-202424", "R-MMU-937041", "R-DRE-9758274", "R-HSA-937039", "R-XTR-5676590", "R-XTR-1169091"], "pathways": ["R-BTA-9909505:r:Modulation of host responses by 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noncanonical NF-kB signaling", "R-MMU-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-XTR-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-HSA-209560:r:NF-kB is activated and signals survival", "R-BTA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-209543:r:p75NTR recruits signalling complexes", "R-HSA-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5674400:r:Constitutive Signaling by AKT1 E17K in Cancer", "R-RNO-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-RNO-209560:r:NF-kB is activated and signals survival", "R-HSA-9758274:r:Regulation of NF-kappa B signaling", "R-GGA-434131:r:NFkB activation mediated by RIP1 complexed with activated TLR3", "R-BTA-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-MMU-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-5602636:r:IKBKB deficiency causes SCID", "R-RNO-209543:r:p75NTR recruits signalling complexes", "R-HSA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-HSA-1169091:r:Activation of NF-kappaB in B cells", "R-DRE-5357905:r:Regulation of TNFR1 signaling", "R-DRE-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-2871837:r:FCERI mediated NF-kB activation", "R-BTA-933542:r:TRAF6 mediated NF-kB activation", "R-MMU-5357905:r:Regulation of TNFR1 signaling", "R-RNO-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-1236974:r:ER-Phagosome pathway", "R-DRE-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-BTA-937039:r:IRAK1 recruits IKK complex", "R-BTA-9833482:r:PKR-mediated signaling", "R-DRE-937039:r:IRAK1 recruits IKK complex", "R-MMU-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-RNO-933542:r:TRAF6 mediated NF-kB activation", "R-HSA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-RNO-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-BTA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-9833482:r:PKR-mediated signaling", "R-HSA-209543:r:p75NTR recruits signalling complexes", "R-HSA-933542:r:TRAF6 mediated NF-kB activation", "R-RNO-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-MMU-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-BTA-5676590:r:NIK-->noncanonical NF-kB signaling", "R-DRE-9833482:r:PKR-mediated signaling", "R-HSA-9909505:r:Modulation of host responses by IFN-stimulated genes", "R-HSA-198323:r:AKT phosphorylates targets in the cytosol", "R-RNO-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-2871837:r:FCERI mediated NF-kB activation", "R-BTA-2871837:r:FCERI mediated NF-kB activation", "R-HSA-5357905:r:Regulation of TNFR1 signaling", "R-MMU-937039:r:IRAK1 recruits IKK complex", "R-BTA-209543:r:p75NTR recruits signalling complexes", "R-BTA-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-DRE-5676590:r:NIK-->noncanonical NF-kB signaling", "R-XTR-445989:r:TAK1-dependent IKK and NF-kappa-B activation", "R-HSA-5607764:r:CLEC7A (Dectin-1) signaling", "R-BTA-209560:r:NF-kB is activated and signals survival", "R-XTR-9758274:r:Regulation of NF-kappa B signaling", "R-RNO-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-MMU-202424:r:Downstream TCR signaling", "R-RNO-937039:r:IRAK1 recruits IKK complex", "R-RNO-937041:r:IKK complex recruitment mediated by RIP1", "R-XTR-2871837:r:FCERI mediated NF-kB activation", "R-GGA-1227739:r:Caspase-8 and -10 mediated induction of NF-kB", "R-RNO-2871837:r:FCERI mediated NF-kB activation", "R-MMU-209560:r:NF-kB is activated and signals survival", "R-RNO-5684264:r:MAP3K8 (TPL2)-dependent MAPK1/3 activation", "R-BTA-9860276:r:SLC15A4:TASL-dependent IRF5 activation", "R-MMU-1169091:r:Activation of NF-kappaB in B cells", "R-GGA-434001:r:TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "R-MMU-5607761:r:Dectin-1 mediated noncanonical NF-kB signaling", "R-MMU-5676590:r:NIK-->noncanonical NF-kB signaling", "R-HSA-1810476:r:RIP-mediated NFkB activation via ZBP1", "R-BTA-9860927:r:Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-XTR-9833482:r:PKR-mediated signaling", "R-HSA-5603027:r:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "R-DRE-975144:r:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "R-HSA-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-RNO-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-1169091:r:Activation of NF-kappaB in B cells", "R-HSA-933543:r:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "R-BTA-9020702:r:Interleukin-1 signaling", "R-BTA-5607764:r:CLEC7A (Dectin-1) signaling", "R-RNO-5357956:r:TNFR1-induced NF-kappa-B signaling pathway", "R-MMU-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-202424:r:Downstream TCR signaling", "R-MMU-937041:r:IKK complex recruitment mediated by RIP1", "R-DRE-9758274:r:Regulation of NF-kappa B signaling", "R-HSA-937039:r:IRAK1 recruits IKK complex", "R-XTR-5676590:r:NIK-->noncanonical NF-kB signaling", "R-XTR-1169091:r:Activation of NF-kappaB in B cells"], "type": "Domain"}, "IPR064034": {"description": "TrmB/TrmBL1, EBD C-terminal subdomain", "go_ids": [], "go_terms": [], "name": "TrmB-TrmBL1_EBD_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064036": {"description": "Alpha-2-macroglobulin, Ig-like domain 3", "go_ids": [], "go_terms": [], "name": "A2M_3rd", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064037": {"description": "Conditioned medium factor, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CMFA_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064038": {"description": "ASTRA-associated protein 1", "go_ids": [], "go_terms": [], "name": "ASA1", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064039": {"description": "Uncharacterised protein PA0049, C-terminal domain", "go_ids": [], "go_terms": [], "name": "PA0049_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064040": {"description": "Verrucosidin biosynthesis cluster protein U3, N-terminal domain", "go_ids": [], "go_terms": [], "name": "VERU3_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064042": {"description": "GAC, N-terminal ARM domain", "go_ids": [], "go_terms": [], "name": "ARM_GAC_1st", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064043": {"description": "Uncharacterized protein E02H4.4", "go_ids": [], "go_terms": [], "name": "E02H4.4", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064044": {"description": "CBP/p300/RT109, histone acetyltransferase domain", "go_ids": [], "go_terms": [], "name": "CBP/p300/RT109_HAT", "pathway_ids": ["R-MMU-8941858", "R-RNO-933541", "R-HSA-8936459", "R-CEL-9701898", "R-RNO-9018519", "R-HSA-9818030", "R-CEL-9617629", "R-HSA-9616222", "R-HSA-9701898", "R-HSA-9614657", "R-HSA-2122947", "R-MMU-6804760", "R-HSA-9931521", "R-HSA-6804760", "R-RNO-9759194", "R-MMU-3371568", "R-CEL-8939246", "R-MMU-350054", "R-HSA-6804114", "R-MMU-6804758", "R-HSA-9793380", "R-RNO-9841922", "R-RNO-5621575", "R-HSA-2644606", "R-HSA-9031628", "R-HSA-9768919", "R-HSA-9833109", "R-CEL-8951936", "R-HSA-8941856", "R-HSA-9705671", "R-CEL-8936459", "R-MMU-2122947", "R-HSA-9735871", "R-CEL-3899300", "R-MMU-9759194", "R-MMU-9029569", "R-HSA-3371568", "R-HSA-9818028", "R-HSA-9617629", "R-RNO-400206", "R-MMU-8951936", "R-HSA-9839394", "R-MMU-3899300", "R-RNO-9856649", "R-HSA-210744", "R-HSA-156711", "R-HSA-381340", "R-MMU-8866907", "R-MMU-9701898", "R-HSA-9707616", "R-HSA-6811555", "R-HSA-350054", "R-HSA-201722", "R-HSA-933541", "R-HSA-9909649", "R-RNO-8941856", "R-RNO-8866907", "R-CEL-9018519", "R-HSA-3214847", "R-HSA-9856649", "R-RNO-9617629", "R-HSA-2426168", "R-MMU-9707564", "R-MMU-9856649", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-1234158", "R-MMU-5689901", "R-MMU-201722", "R-MMU-8939246", "R-HSA-9818749", "R-HSA-1368108", "R-HSA-9841922", "R-MMU-1234158", "R-RNO-350054", "R-HSA-9933387", "R-HSA-9707564", "R-CEL-9856649", "R-HSA-9018519", "R-HSA-8951936", "R-RNO-3134973", "R-MMU-8936459", "R-MMU-5250924", "R-MMU-5621575", "R-HSA-8941858", "R-MMU-3134973", "R-CEL-9759194", "R-MMU-9018519", "R-HSA-9013695", "R-HSA-8939243", "R-HSA-9818026", "R-HSA-400206", "R-HSA-3134973", "R-MMU-400206", "R-HSA-5617472", "R-HSA-9818027", "R-HSA-5689901", "R-HSA-9819196", "R-MMU-933541", "R-RNO-201722", "R-HSA-9818035", "R-CEL-201722", "R-MMU-9617629", "R-RNO-8939246", "R-HSA-1912408", "R-HSA-6804758", "R-RNO-3371568", "R-HSA-918233", "R-HSA-5621575", "R-HSA-9759194", "R-HSA-9029569", "R-HSA-2173796", "R-HSA-9931509", "R-CEL-1234158", "R-HSA-8866907", "R-HSA-9013508", "R-HSA-2894862", "R-RNO-9707564", "R-MMU-8939243", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-6803204", "R-HSA-9818032", "R-MMU-8941856", "R-HSA-5250924", "R-MMU-6811555", "R-RNO-1234158", "R-HSA-3899300", "R-HSA-2197563", "R-HSA-8939246", "R-CEL-8939243"], "pathways": ["R-MMU-8941858:r:Regulation of RUNX3 expression and activity", "R-RNO-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-CEL-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-RNO-9018519:r:Estrogen-dependent gene expression", "R-HSA-9818030:r:NFE2L2 regulating tumorigenic genes", "R-CEL-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-9616222:r:Transcriptional regulation of granulopoiesis", "R-HSA-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9614657:r:FOXO-mediated transcription of cell death genes", "R-HSA-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-MMU-6804760:r:Regulation of TP53 Activity through Methylation", "R-HSA-9931521:r:The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-6804760:r:Regulation of TP53 Activity through Methylation", "R-RNO-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-3371568:r:Attenuation phase", "R-CEL-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-MMU-350054:r:Notch-HLH transcription pathway", "R-HSA-6804114:r:TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-MMU-6804758:r:Regulation of TP53 Activity through Acetylation", "R-HSA-9793380:r:Formation of paraxial mesoderm", "R-RNO-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-RNO-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-2644606:r:Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-9031628:r:NGF-stimulated transcription", "R-HSA-9768919:r:NPAS4 regulates expression of target genes", "R-HSA-9833109:r:Evasion by RSV of host interferon responses", "R-CEL-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-9705671:r:SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-CEL-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-2122947:r:NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-9735871:r:SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-CEL-3899300:r:SUMOylation of transcription cofactors", "R-MMU-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-3371568:r:Attenuation phase", "R-HSA-9818028:r:NFE2L2 regulates pentose phosphate pathway genes", "R-HSA-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-400206:r:Regulation of lipid metabolism by PPARalpha", "R-MMU-8951936:r:RUNX3 regulates p14-ARF", "R-HSA-9839394:r:TGFBR3 expression", "R-MMU-3899300:r:SUMOylation of transcription cofactors", "R-RNO-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-210744:r:Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "R-HSA-156711:r:Polo-like kinase mediated events", "R-HSA-381340:r:Transcriptional regulation of white adipocyte differentiation", "R-MMU-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-MMU-9701898:r:STAT3 nuclear events downstream of ALK signaling", "R-HSA-9707616:r:Heme signaling", "R-HSA-6811555:r:PI5P Regulates TP53 Acetylation", "R-HSA-350054:r:Notch-HLH transcription pathway", "R-HSA-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-933541:r:TRAF6 mediated IRF7 activation", "R-HSA-9909649:r:Regulation of PD-L1(CD274) transcription", "R-RNO-8941856:r:RUNX3 regulates NOTCH signaling", "R-RNO-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-CEL-9018519:r:Estrogen-dependent gene expression", "R-HSA-3214847:r:HATs acetylate histones", "R-HSA-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-RNO-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-HSA-2426168:r:Activation of gene expression by SREBF (SREBP)", "R-MMU-9707564:r:Cytoprotection by HMOX1", "R-MMU-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-1989781:r:PPARA activates gene expression", "R-HSA-2151201:r:Transcriptional activation of mitochondrial biogenesis", "R-HSA-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-MMU-5689901:r:Metalloprotease DUBs", "R-MMU-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-9818749:r:Regulation of NFE2L2 gene expression", "R-HSA-1368108:r:BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-9841922:r:MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-MMU-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-RNO-350054:r:Notch-HLH transcription pathway", "R-HSA-9933387:r:RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression", "R-HSA-9707564:r:Cytoprotection by HMOX1", "R-CEL-9856649:r:Transcriptional and post-translational regulation of MITF-M expression and activity", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-8951936:r:RUNX3 regulates p14-ARF", "R-RNO-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-8936459:r:RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-MMU-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-8941858:r:Regulation of RUNX3 expression and activity", "R-MMU-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-CEL-9759194:r:Nuclear events mediated by NFE2L2", "R-MMU-9018519:r:Estrogen-dependent gene expression", "R-HSA-9013695:r:NOTCH4 Intracellular Domain Regulates Transcription", "R-HSA-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9818026:r:NFE2L2 regulating inflammation associated genes", "R-HSA-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-3134973:r:LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "R-MMU-400206:r:Regulation of lipid metabolism by PPARalpha", "R-HSA-5617472:r:Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-9818027:r:NFE2L2 regulating anti-oxidant/detoxification enzymes", "R-HSA-5689901:r:Metalloprotease DUBs", "R-HSA-9819196:r:Zygotic genome activation (ZGA)", "R-MMU-933541:r:TRAF6 mediated IRF7 activation", "R-RNO-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-HSA-9818035:r:NFE2L2 regulating ER-stress associated genes", "R-CEL-201722:r:Formation of the beta-catenin:TCF transactivating complex", "R-MMU-9617629:r:Regulation of FOXO transcriptional activity by acetylation", "R-RNO-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-1912408:r:Pre-NOTCH Transcription and Translation", "R-HSA-6804758:r:Regulation of TP53 Activity through Acetylation", "R-RNO-3371568:r:Attenuation phase", "R-HSA-918233:r:TRAF3-dependent IRF activation pathway", "R-HSA-5621575:r:CD209 (DC-SIGN) signaling", "R-HSA-9759194:r:Nuclear events mediated by NFE2L2", "R-HSA-9029569:r:NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-2173796:r:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-9931509:r:Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-CEL-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-8866907:r:Activation of the TFAP2 (AP-2) family of transcription factors", "R-HSA-9013508:r:NOTCH3 Intracellular Domain Regulates Transcription", "R-HSA-2894862:r:Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-RNO-9707564:r:Cytoprotection by HMOX1", "R-MMU-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-9931510:r:Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512:r:Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-6803204:r:TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-9818032:r:NFE2L2 regulating MDR associated enzymes", "R-MMU-8941856:r:RUNX3 regulates NOTCH signaling", "R-HSA-5250924:r:B-WICH complex positively regulates rRNA expression", "R-MMU-6811555:r:PI5P Regulates TP53 Acetylation", "R-RNO-1234158:r:Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-3899300:r:SUMOylation of transcription cofactors", "R-HSA-2197563:r:NOTCH2 intracellular domain regulates transcription", "R-HSA-8939246:r:RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-CEL-8939243:r:RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "type": "Domain"}, "IPR064045": {"description": "GLGC, left-handed parallel beta-helix domain", "go_ids": [], "go_terms": [], "name": "LbH_GLGC", "pathway_ids": ["PWY-7902", "PWY-622"], "pathways": ["PWY-7902:t:glucosylglycerol biosynthesis", "PWY-622:t:starch biosynthesis"], "type": "Domain"}, "IPR064046": {"description": "ANTKMT-like, methyltransferase domain", "go_ids": [], "go_terms": [], "name": "Methyltransf_ANTKMT", "pathway_ids": ["PWY-7045", "PWY-7161", "PWY-7751", "PWY-8426", "PWY-8238", "PWY-7743", "PWY-7689", "PWY-7100", "PWY-5665", "PWY-8364", "PWY-7151", "PWY-3542", "PWY-8381", "PWY-7717", "PWY-7517", "PWY-7440", "PWY-8437", "PWY-6310", "PWY-7692", "PWY-7498", "PWY-6148", "PWY-8077", "PWY-8380", "PWY-6739", "PWY-6427", "PWY-7135", "PWY-7485", "PWY-7659", "PWY-7150", "PWY-7667", "PWY-7643", "PWY-6835", "PWY-8076", "PWY-5479", "PWY-8424", "PWY-2083", "PWY-8361", "PWY-4021", "PWY-8100", "PWY-7745", "PWY-8463", "PWY-5305", "PWY-7977", "PWY-7629", "PWY-7055", "PWY-7607", "PWY-7163", "PWY-5059", "PWY-6736", "PWY-8368", "PWY-8122", "PWY-7547", "PWY-5301", "PWY-8172", "PWY-5729", "PWY-5773", "PWY-7155", "PWY-7076", "PWY-7737", "PWY-6682", "PWY-8104", "PWY-6045", "PWY-7608", "PWY-7439", "PWY-8379", "PWY-7668", "PWY-7564", "PWY-8047", "PWY-7104", "PWY-7569", "PWY-7534", "PWY-1061", "PWY-7811", "PWY-7673", "PWY-7655", "PWY-6339", "PWY-8326", "PWY-5748", "PWY-7285", "PWY-8040", "PWY-7735", "PWY-8103", "PWY-6286", "PWY-4202", "PWY-6581", "PWY-7186", "PWY-7705", "PWY-8036", "PWY-5975", "PWY-6795", "PWY-7301", "PWY-7669", "PWY-8367", "PWY-8212", "PWY-7325", "PWY-7739", "PWY-6955", "PWY-7483", "PWY-8257", "PWY-6973", "PWYG-321", "PWY-5883", "PWY-5105", "PWY-7742", "PWY-6477", "PWY-7826", "PWY-7298", "PWY-8035", "PWY-7157", "PWY-7533", "PWY-7160", "PWY-8210", "PWY-7072", "PWY-7729", "PWY-7695", "PWY-5765", "PWY-7765", "PWY-8438", "PWY-7614", "PWY-8031", "PWY-6978", "PWY-8327", "PWY-6976", "PWY-7025", "PWY-8096", "PWY-8095", "PWY-6153", "PWY-5846", "PWY-7671", "PWY-7058", "PWY-7691", "PWY-7653", "PWY-6154", "PWY-601", "PWY-4161", "PWY-7591", "PWY-7363", "PWY-6346", "PWY-7570", "PWY-7079", "PWY-7661", "PWY-7741", "PWY-6442", "PWY-7631", "PWY-5987"], "pathways": ["PWY-7045:t:mithramycin biosynthesis", "PWY-7161:t:polymethylated quercetin biosynthesis", "PWY-7751:t:shinorine biosynthesis", "PWY-8426:t:(2R)-methoxymalonyl-[acp] biosynthesis", "PWY-8238:t:24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)", "PWY-7743:t:dimycocerosyl triglycosyl phenolphthiocerol biosynthesis", "PWY-7689:t:8-O-methylfusarubin biosynthesis", "PWY-7100:t:spinosyn biosynthesis", "PWY-5665:t:vanillin biosynthesis I", "PWY-8364:t:7,8-dimethylmenaquinone biosynthesis", "PWY-7151:t:polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)", "PWY-3542:t:choline biosynthesis II", "PWY-8381:t:sulfazecin biosynthesis", "PWY-7717:t:3-hydroxy-4-methyl-anthranilate biosynthesis I", "PWY-7517:t:brassicicene C biosynthesis", "PWY-7440:t:dTDP-beta-L-4-epi-vancosamine biosynthesis", "PWY-8437:t:furaquinocin biosynthesis", "PWY-6310:t:aloenin biosynthesis", "PWY-7692:t:bikaverin biosynthesis", "PWY-7498:t:phenylpropanoids methylation (ice plant)", "PWY-6148:t:tetrahydromethanopterin biosynthesis", "PWY-8077:t:ginkgotoxin biosynthesis", "PWY-8380:t:dTDP-sibirosamine biosynthesis", "PWY-6739:t:pinitol biosynthesis II", "PWY-6427:t:rot-2'-enonate biosynthesis", "PWY-7135:t:emetine biosynthesis", "PWY-7485:t:tetracenomycin C biosynthesis", "PWY-7659:t:viridicatumtoxin biosynthesis", "PWY-7150:t:polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)", "PWY-7667:t:apicidin biosynthesis", "PWY-7643:t:coniferyl alcohol 9-methyl ether biosynthesis", "PWY-6835:t:6-gingerol biosynthesis", "PWY-8076:t:8-O-methylated benzoxazinoid glucoside biosynthesis", "PWY-5479:t:6-methoxypodophyllotoxin biosynthesis", "PWY-8424:t:ascomycin biosynthesis", "PWY-2083:t:isoflavonoid biosynthesis II", "PWY-8361:t:apratoxin A biosynthesis", "PWY-4021:t:beta-alanine betaine biosynthesis", "PWY-8100:t:crotonosine biosynthesis", "PWY-7745:t:p-HBAD biosynthesis", "PWY-8463:t:5,6-dehydrokavain biosynthesis (engineered)", "PWY-5305:t:bixin biosynthesis", "PWY-7977:t:L-methionine biosynthesis IV", "PWY-7629:t:yatein biosynthesis II", "PWY-7055:t:daphnetin modification", "PWY-7607:t:meleagrin biosynthesis", "PWY-7163:t:polymethylated kaempferol biosynthesis", "PWY-5059:t:pinobanksin biosynthesis", "PWY-6736:t:sulfur volatiles biosynthesis", "PWY-8368:t:clorobiocin biosynthesis", "PWY-8122:t:mycofactocin biosynthesis", "PWY-7547:t:prodigiosin biosynthesis", "PWY-5301:t:ajmaline and sarpagine biosynthesis", "PWY-8172:t:10-methylstearate biosynthesis", "PWY-5729:t:vestitol and sativan biosynthesis", "PWY-5773:t:gossypol biosynthesis", "PWY-7155:t:7-dehydroporiferasterol biosynthesis", "PWY-7076:t:3,5-dimethoxytoluene biosynthesis", "PWY-7737:t:thiocoraline biosynthesis", "PWY-6682:t:dehydrophos biosynthesis", "PWY-8104:t:yangonin biosynthesis", "PWY-6045:t:methylthiopropanonate degradation II (demethylation)", "PWY-7608:t:neoxaline biosynthesis", "PWY-7439:t:dTDP-beta-L-evernitrose biosynthesis", "PWY-8379:t:sibiromycin biosynthesis", "PWY-7668:t:apicidin F biosynthesis", "PWY-7564:t:bacimethrin and bacimethrin pyrophosphate biosynthesis", "PWY-8047:t:bryostatin biosynthesis", "PWY-7104:t:dTDP-beta-L-megosamine biosynthesis", "PWY-7569:t:arginomycin biosynthesis", "PWY-7534:t:gliotoxin inactivation", "PWY-1061:t:homogalacturonan biosynthesis", "PWY-7811:t:6-methylpretetramide biosynthesis", "PWY-7673:t:fusarin C biosynthesis", "PWY-7655:t:dechlorogriseofulvin biosynthesis", "PWY-6339:t:syringate degradation", "PWY-8326:t:grayanate biosynthesis", "PWY-5748:t:gamma-coniciene and coniine biosynthesis", "PWY-7285:t:methylwyosine biosynthesis", "PWY-8040:t:ansatrienin biosynthesis", "PWY-7735:t:echinomycin and triostin A biosynthesis", "PWY-8103:t:kavain biosynthesis", "PWY-6286:t:spheroidene and spheroidenone biosynthesis", "PWY-4202:t:arsenic detoxification (mammals)", "PWY-6581:t:spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis", "PWY-7186:t:superpathway of scopolin and esculin biosynthesis", "PWY-7705:t:quinolinone B biosynthesis", "PWY-8036:t:chaxamycin biosynthesis", "PWY-5975:t:furaneol and mesifurane biosynthesis", "PWY-6795:t:diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis", "PWY-7301:t:dTDP-4-O-demethyl-beta-L-noviose biosynthesis", "PWY-7669:t:equisetin biosynthesis", "PWY-8367:t:hygromycin B biosynthesis", "PWY-8212:t:Escherichia coli serotype O:8 O antigen biosynthesis", "PWY-7325:t:salvigenin biosynthesis", "PWY-7739:t:aucuparin biosynthesis", "PWY-6955:t:lincomycin A biosynthesis", "PWY-7483:t:elloramycin biosynthesis", "PWY-8257:t:Escherichia coli serotype O:52 O antigen biosynthesis", "PWY-6973:t:dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis", "PWYG-321:t:mycolate biosynthesis", "PWY-5883:t:ephedrine biosynthesis", "PWY-5105:t:hesperitin glycoside biosynthesis", "PWY-7742:t:phenolphthiocerol biosynthesis", "PWY-6477:t:gibberellin inactivation II (methylation)", "PWY-7826:t:Amaryllidacea alkaloids biosynthesis", "PWY-7298:t:nevadensin biosynthesis", "PWY-8035:t:streptovaricin biosynthesis", "PWY-7157:t:eupatolitin 3-O-glucoside biosynthesis", "PWY-7533:t:gliotoxin biosynthesis", "PWY-7160:t:polymethylated myricetin biosynthesis (tomato)", "PWY-8210:t:pyrrolomycin biosynthesis", "PWY-7072:t:hopanoid biosynthesis (bacteria)", "PWY-7729:t:5,6-dimethylbenzimidazole biosynthesis II (anaerobic)", "PWY-7695:t:aurofusarin biosynthesis", "PWY-5765:t:1,3,5-trimethoxybenzene biosynthesis", "PWY-7765:t:3-hydroxy-4-methyl-anthranilate biosynthesis II", "PWY-8438:t:corallopyronin A biosynthesis", "PWY-7614:t:methiin metabolism", "PWY-8031:t:epiberberine biosynthesis", "PWY-6978:t:plastoquinol-9 biosynthesis II", "PWY-8327:t:atranorin biosynthesis", "PWY-6976:t:dTDP-beta-L-mycarose biosynthesis", "PWY-7025:t:gentamicin biosynthesis", "PWY-8096:t:5-methoxybenzimidazole biosynthesis (anaerobic)", "PWY-8095:t:5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)", "PWY-6153:t:autoinducer AI-2 biosynthesis I", "PWY-5846:t:colchicine biosynthesis", "PWY-7671:t:saframycin A biosynthesis", "PWY-7058:t:esculetin modification", "PWY-7691:t:10,13-epoxy-11-methyl-octadecadienoate biosynthesis", "PWY-7653:t:griseofulvin biosynthesis", "PWY-6154:t:autoinducer AI-2 biosynthesis II (Vibrio)", "PWY-601:t:glucosinolate biosynthesis from tryptophan", "PWY-4161:t:superpathway of benzoxazinoid glucosides biosynthesis", "PWY-7591:t:okenone biosynthesis", "PWY-7363:t:papaverine biosynthesis", "PWY-6346:t:staurosporine biosynthesis", "PWY-7570:t:blasticidin S biosynthesis", "PWY-7079:t:geodin biosynthesis", "PWY-7661:t:protein N-glycosylation (Haloferax volcanii)", "PWY-7741:t:phthiocerol biosynthesis", "PWY-6442:t:spermidine hydroxycinnamic acid conjugates biosynthesis", "PWY-7631:t:arctigenin and isoarctigenin biosynthesis", "PWY-5987:t:sorgoleone biosynthesis"], "type": "Domain"}, "IPR064047": {"description": "VPS18, alpha-solenoid domain, second half", "go_ids": [], "go_terms": [], "name": "VPS18_solenoid_2nd", "pathway_ids": ["R-HSA-9754560"], "pathways": ["R-HSA-9754560:r:SARS-CoV-2 modulates autophagy"], "type": "Domain"}, "IPR064048": {"description": "Endolysin", "go_ids": [], "go_terms": [], "name": "Endolysin", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064049": {"description": "Tuftelin-like, coiled-coil", "go_ids": [], "go_terms": [], "name": "Tuftelin-like_CC", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064050": {"description": "TGF-alpha/betacellulin-like, EGF domain", "go_ids": [], "go_terms": [], "name": "EGF_TGFA-like", "pathway_ids": ["R-MMU-1250342", "R-MMU-182971", "R-MMU-204005", "R-MMU-8856828", "R-MMU-6785631", "R-MMU-180336", "R-HSA-180292", "R-MMU-6811558", "R-HSA-8856828", "R-MMU-5694530", "R-RNO-9009391", "R-MMU-9009391", "R-HSA-9927418", "R-HSA-5694530", "R-MMU-1963640", "R-HSA-8863795", "R-RNO-6811558", "R-HSA-177929", "R-MMU-1236394", "R-HSA-9664565", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-9018519", "R-HSA-212718", "R-RNO-212718", "R-RNO-179812", "R-HSA-182971", "R-HSA-9665686", "R-MMU-180292", "R-HSA-8847993", "R-HSA-2219530", "R-HSA-5673001", "R-HSA-6811558", "R-HSA-204005", "R-MMU-179812", "R-MMU-1963642", "R-MMU-1250196", "R-HSA-1257604", "R-HSA-179812", "R-MMU-8863795", "R-HSA-5638303", "R-MMU-8856825", "R-HSA-1251985", "R-RNO-1257604", "R-HSA-1250342", "R-HSA-1250347", "R-MMU-8847993", "R-MMU-1250347", "R-HSA-8866910", "R-HSA-1963642", "R-HSA-1250196", "R-RNO-8856828", "R-RNO-177929", "R-HSA-1963640", "R-RNO-5694530", "R-RNO-8856825", "R-MMU-1227986", "R-HSA-9927432", "R-HSA-6785631", "R-HSA-1227986", "R-MMU-1257604", "R-RNO-180292", "R-HSA-9634638", "R-RNO-204005", "R-HSA-180336", "R-HSA-1236394", "R-HSA-9009391", "R-MMU-212718", "R-HSA-8856825", "R-RNO-180336", "R-RNO-182971", "R-MMU-177929"], "pathways": ["R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-182971:r:EGFR downregulation", "R-MMU-204005:r:COPII-mediated vesicle transport", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-MMU-5694530:r:Cargo concentration in the ER", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-9927418:r:Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-5694530:r:Cargo concentration in the ER", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-177929:r:Signaling by EGFR", "R-MMU-1236394:r:Signaling by ERBB4", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-9018519:r:Estrogen-dependent gene expression", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-HSA-182971:r:EGFR downregulation", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-MMU-180292:r:GAB1 signalosome", "R-HSA-8847993:r:ERBB2 Activates PTK6 Signaling", "R-HSA-2219530:r:Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-5673001:r:RAF/MAP kinase cascade", "R-HSA-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-204005:r:COPII-mediated vesicle transport", "R-MMU-179812:r:GRB2 events in EGFR signaling", "R-MMU-1963642:r:PI3K events in ERBB2 signaling", "R-MMU-1250196:r:SHC1 events in ERBB2 signaling", "R-HSA-1257604:r:PIP3 activates AKT signaling", "R-HSA-179812:r:GRB2 events in EGFR signaling", "R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-8866910:r:TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-177929:r:Signaling by EGFR", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-5694530:r:Cargo concentration in the ER", "R-RNO-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-1227986:r:Signaling by ERBB2", "R-HSA-9927432:r:Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-6785631:r:ERBB2 Regulates Cell Motility", "R-HSA-1227986:r:Signaling by ERBB2", "R-MMU-1257604:r:PIP3 activates AKT signaling", "R-RNO-180292:r:GAB1 signalosome", "R-HSA-9634638:r:Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-RNO-204005:r:COPII-mediated vesicle transport", "R-HSA-180336:r:SHC1 events in EGFR signaling", "R-HSA-1236394:r:Signaling by ERBB4", "R-HSA-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-RNO-180336:r:SHC1 events in EGFR signaling", "R-RNO-182971:r:EGFR downregulation", "R-MMU-177929:r:Signaling by EGFR"], "type": "Domain"}, "IPR064051": {"description": "UBR7-like, PHD finger", "go_ids": [], "go_terms": [], "name": "PHD_UBR7-like", "pathway_ids": ["R-HSA-3214842", "R-MMU-3214842", "R-HSA-6802952"], "pathways": ["R-HSA-3214842:r:HDMs demethylate histones", "R-MMU-3214842:r:HDMs demethylate histones", "R-HSA-6802952:r:Signaling by BRAF and RAF1 fusions"], "type": "Domain"}, "IPR064052": {"description": "WAR1-like domain", "go_ids": [], "go_terms": [], "name": "WAR1-like_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064054": {"description": "Intraflagellar transport protein 70, C-terminal domain", "go_ids": [], "go_terms": [], "name": "IFT70_C", "pathway_ids": ["R-HSA-5620924", "R-RNO-5620924", "R-CEL-5620924", "R-BTA-5620924", "R-XTR-5620924", "R-MMU-5620924"], "pathways": ["R-HSA-5620924:r:Intraflagellar transport", "R-RNO-5620924:r:Intraflagellar transport", "R-CEL-5620924:r:Intraflagellar transport", "R-BTA-5620924:r:Intraflagellar transport", "R-XTR-5620924:r:Intraflagellar transport", "R-MMU-5620924:r:Intraflagellar transport"], "type": "Domain"}, "IPR064055": {"description": "STR4, middle domain", "go_ids": [], "go_terms": [], "name": "STR4_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064056": {"description": "ETO1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ETO1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064057": {"description": "MIA2/CTAGE5, coiled-coil domain", "go_ids": [], "go_terms": [], "name": "MIA2_CC", "pathway_ids": ["R-HSA-5694530", "R-MMU-5694530"], "pathways": ["R-HSA-5694530:r:Cargo concentration in the ER", "R-MMU-5694530:r:Cargo concentration in the ER"], "type": "Domain"}, "IPR064058": {"description": "Lysyl endopeptidase-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "LYSC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064059": {"description": "Beta-porphyranase A-D, GH16 domain", "go_ids": [], "go_terms": [], "name": "GH16_PorA-D", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064060": {"description": "Increased DNA methylation 2/3-like, C-terminal domain", "go_ids": [], "go_terms": [], "name": "IDM_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064061": {"description": "Alpha-Dystroglycan, third Ig-like domain", "go_ids": [], "go_terms": [], "name": "Ig_DAG1", "pathway_ids": ["R-MMU-8932505", "R-HSA-8932505", "R-CFA-9939291", "R-HSA-3000178", "R-HSA-8932504", "R-HSA-5083633", "R-HSA-3000171", "R-HSA-9913351", "R-HSA-9619665", "R-HSA-9010553", "R-MMU-9939291", "R-MMU-9010553", "R-CFA-9913351", "R-HSA-8932506", "R-MMU-9913351", "R-MMU-8932504", "R-CFA-9010553", "R-CFA-8932506", "R-CFA-8932504", "R-HSA-9939291", "R-HSA-5083629", "R-HSA-5083628", "R-CFA-8932505", "R-MMU-8932506"], "pathways": ["R-MMU-8932505:r:DAG1 core M3 glycosylations", "R-HSA-8932505:r:DAG1 core M3 glycosylations", "R-CFA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-3000178:r:ECM proteoglycans", "R-HSA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-5083633:r:Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "R-HSA-3000171:r:Non-integrin membrane-ECM interactions", "R-HSA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9619665:r:EGR2 and SOX10-mediated initiation of Schwann cell myelination", "R-HSA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-MMU-9939291:r:Matriglycan biosynthesis on DAG1", "R-MMU-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-8932506:r:DAG1 core M1 glycosylations", "R-MMU-9913351:r:Formation of the dystrophin-glycoprotein complex (DGC)", "R-MMU-8932504:r:DAG1 core M2 glycosylations", "R-CFA-9010553:r:Regulation of expression of SLITs and ROBOs", "R-CFA-8932506:r:DAG1 core M1 glycosylations", "R-CFA-8932504:r:DAG1 core M2 glycosylations", "R-HSA-9939291:r:Matriglycan biosynthesis on DAG1", "R-HSA-5083629:r:Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "R-HSA-5083628:r:Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "R-CFA-8932505:r:DAG1 core M3 glycosylations", "R-MMU-8932506:r:DAG1 core M1 glycosylations"], "type": "Domain"}, "IPR064063": {"description": "ARMC6, C-terminal domain", "go_ids": [], "go_terms": [], "name": "ARMC6_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064064": {"description": "SRF1, C-terminal domain", "go_ids": [], "go_terms": [], "name": "SRF1_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064065": {"description": "TIM14, C-terminal domain", "go_ids": [], "go_terms": [], "name": "TIM14_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064066": {"description": "NLRC3, LRR domain", "go_ids": [], "go_terms": [], "name": "LRR_NLRC3", "pathway_ids": ["R-HSA-3270619"], "pathways": ["R-HSA-3270619:r:IRF3-mediated induction of type I IFN"], "type": "Domain"}, "IPR064067": {"description": "Angiopoietin-like protein 3/8, helix-hairpin domain", "go_ids": [], "go_terms": [], "name": "ANGPTL3/8_HH", "pathway_ids": ["R-MMU-8963889", "R-HSA-8963889", "R-HSA-9029558"], "pathways": ["R-MMU-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-8963889:r:Assembly of active LPL and LIPC lipase complexes", "R-HSA-9029558:r:NR1H2 & NR1H3 regulate gene expression linked to lipogenesis"], "type": "Domain"}, "IPR064068": {"description": "CadC, C-terminal domain", "go_ids": [], "go_terms": [], "name": "CadC_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064069": {"description": "Phage repressor, winged helix-turn-helix", "go_ids": [], "go_terms": [], "name": "WHD_phage_rep", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064070": {"description": "Methanogenesis regulatory protein FilR1/ArnR, N-terminal domain", "go_ids": [], "go_terms": [], "name": "FilR1/ArnR_N", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064071": {"description": "Nucleoporin NUP53, middle domain", "go_ids": [], "go_terms": [], "name": "NUP53_M", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064072": {"description": "TMCO6, ARM-like domain", "go_ids": [], "go_terms": [], "name": "TMCO6", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064073": {"description": "C6orf89, C-terminal domain", "go_ids": [], "go_terms": [], "name": "C6orf89_C", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064074": {"description": "NUP58, middle domain", "go_ids": [], "go_terms": [], "name": "NUP58_M", 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"go_ids": [], "go_terms": [], "name": "TEX26", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064080": {"description": "UPF0450 protein C17orf58-like domain", "go_ids": [], "go_terms": [], "name": "C17orf58_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064081": {"description": "YGR117C-like, LisH domain", "go_ids": [], "go_terms": [], "name": "LisH_YGR117C-like", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064082": {"description": "Epiregulin, EGF-like domain", "go_ids": [], "go_terms": [], "name": "EGF_Epiregulin", "pathway_ids": ["R-MMU-8863795", "R-MMU-1250342", "R-MMU-6785631", "R-MMU-8856828", "R-HSA-5638303", "R-MMU-182971", "R-MMU-180336", "R-RNO-6785631", "R-RNO-1250347", "R-HSA-180292", "R-MMU-8856825", "R-MMU-6811558", "R-HSA-8856828", "R-HSA-1251985", "R-RNO-1257604", "R-RNO-9009391", "R-MMU-9009391", "R-HSA-1250342", "R-HSA-1250347", "R-RNO-8863795", "R-MMU-1963640", "R-HSA-8863795", "R-MMU-8847993", "R-RNO-8847993", "R-RNO-6811558", "R-MMU-1250347", "R-RNO-1963642", "R-HSA-1963642", "R-HSA-177929", "R-HSA-1250196", "R-MMU-1236394", "R-RNO-8856828", "R-RNO-177929", "R-HSA-9664565", "R-RNO-5673001", "R-MMU-5673001", "R-HSA-212718", "R-RNO-212718", "R-HSA-1963640", "R-RNO-179812", "R-HSA-9665686", "R-HSA-182971", "R-MMU-180292", "R-RNO-8856825", "R-RNO-1963640", "R-HSA-8847993", "R-RNO-1250342", "R-MMU-1227986", "R-RNO-1227986", "R-HSA-1227986", "R-HSA-6785631", "R-HSA-2219530", "R-MMU-1257604", "R-RNO-180292", "R-HSA-9634638", "R-HSA-180336", "R-HSA-1236394", "R-HSA-5673001", "R-HSA-6811558", "R-HSA-9009391", "R-MMU-212718", "R-HSA-8856825", "R-MMU-179812", "R-MMU-1963642", "R-RNO-180336", "R-RNO-1236394", "R-MMU-1250196", "R-RNO-1250196", "R-RNO-182971", "R-HSA-1257604", "R-HSA-179812", "R-MMU-177929"], "pathways": ["R-MMU-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-1250342:r:PI3K events in ERBB4 signaling", "R-MMU-6785631:r:ERBB2 Regulates Cell Motility", "R-MMU-8856828:r:Clathrin-mediated endocytosis", "R-HSA-5638303:r:Inhibition of Signaling by Overexpressed EGFR", "R-MMU-182971:r:EGFR downregulation", "R-MMU-180336:r:SHC1 events in EGFR signaling", "R-RNO-6785631:r:ERBB2 Regulates Cell Motility", "R-RNO-1250347:r:SHC1 events in ERBB4 signaling", "R-HSA-180292:r:GAB1 signalosome", "R-MMU-8856825:r:Cargo recognition for clathrin-mediated endocytosis", "R-MMU-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-8856828:r:Clathrin-mediated endocytosis", "R-HSA-1251985:r:Nuclear signaling by ERBB4", "R-RNO-1257604:r:PIP3 activates AKT signaling", "R-RNO-9009391:r:Extra-nuclear estrogen signaling", "R-MMU-9009391:r:Extra-nuclear estrogen signaling", "R-HSA-1250342:r:PI3K events in ERBB4 signaling", "R-HSA-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-1963640:r:GRB2 events in ERBB2 signaling", "R-HSA-8863795:r:Downregulation of ERBB2 signaling", "R-MMU-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-8847993:r:ERBB2 Activates PTK6 Signaling", "R-RNO-6811558:r:PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-MMU-1250347:r:SHC1 events in ERBB4 signaling", "R-RNO-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-1963642:r:PI3K events in ERBB2 signaling", "R-HSA-177929:r:Signaling by EGFR", "R-HSA-1250196:r:SHC1 events in ERBB2 signaling", "R-MMU-1236394:r:Signaling by ERBB4", "R-RNO-8856828:r:Clathrin-mediated endocytosis", "R-RNO-177929:r:Signaling by EGFR", "R-HSA-9664565:r:Signaling by ERBB2 KD Mutants", "R-RNO-5673001:r:RAF/MAP kinase cascade", "R-MMU-5673001:r:RAF/MAP kinase cascade", "R-HSA-212718:r:EGFR interacts with phospholipase C-gamma", "R-RNO-212718:r:EGFR interacts with phospholipase C-gamma", "R-HSA-1963640:r:GRB2 events in ERBB2 signaling", "R-RNO-179812:r:GRB2 events in EGFR signaling", "R-HSA-9665686:r:Signaling by ERBB2 TMD/JMD mutants", "R-HSA-182971:r:EGFR downregulation", "R-MMU-180292:r:GAB1 signalosome", 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"pathways": [], "type": "Family"}, "IPR064327": {"description": "ABC ion transporter substrate-binding protein EitA", "go_ids": [], "go_terms": [], "name": "EitA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064328": {"description": "Blue-light photoreceptor YtvA-like", "go_ids": [], "go_terms": [], "name": "YtvA-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064329": {"description": "YknW membrane protein", "go_ids": [], "go_terms": [], "name": "YknW", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064330": {"description": "ABC ion transporter substrate-binding protein EitC", "go_ids": [], "go_terms": [], "name": "EitC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064331": {"description": "Anti-apoptotic factor Rv3033", "go_ids": [], "go_terms": [], "name": "Rv3033", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064332": {"description": "EspM", "go_ids": [], "go_terms": [], "name": "EspM", "pathway_ids": [], 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"pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064339": {"description": "Outer surface 22 kDa lipoprotein", "go_ids": [], "go_terms": [], "name": "P22", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064340": {"description": "T9SS-dependent surface endonuclease, AS87_RS02955-like", "go_ids": [], "go_terms": [], "name": "T9SS_DNase_Rie", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064341": {"description": "Endodextranase FjGH66", "go_ids": [], "go_terms": [], "name": "FjGH66", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064342": {"description": "MSMEG_1198-like", "go_ids": [], "go_terms": [], "name": "MSMEG_1198-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064343": {"description": "Peptidoglycan release complex CPBP-like subunit SdpC", "go_ids": [], "go_terms": [], "name": "CPBP_SdpC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064344": {"description": "StpK7/MSMEG_1200", "go_ids": [], "go_terms": [], "name": "StpK7/MSMEG_1200", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064346": {"description": "Peptidoglycan release complex glucosaminidase SagB", "go_ids": [], "go_terms": [], "name": "Amidase_SagB", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064347": {"description": "Copper-sensing transcriptional repressor RicR", "go_ids": [], "go_terms": [], "name": "RicR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064348": {"description": "CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein", "go_ids": [], "go_terms": [], "name": "CAAX_protease-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064349": {"description": "Polyketide cyclase", "go_ids": [], "go_terms": [], "name": "Pkt_cyclase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064350": {"description": "Flavin reductase FerA", "go_ids": [], "go_terms": [], "name": "Flvn_Red_FerA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064351": {"description": "Alpha-l-rhamnosidase BT3686", "go_ids": [], "go_terms": [], "name": "BT3686", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064352": {"description": "Organic hydroperoxide reductase Ohr", "go_ids": [], "go_terms": [], "name": "Hydprx_Ohr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064353": {"description": "MusI", "go_ids": [], "go_terms": [], "name": "MusI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064354": {"description": "Putative adhesin RC1281/RP828-like", "go_ids": [], "go_terms": [], "name": "RC1281/RP828-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064355": {"description": "Inclusion membrane protein TC0500, putative", "go_ids": [], "go_terms": [], "name": "TC0500_Inc", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064356": {"description": "Riean_0653-like", "go_ids": [], "go_terms": [], "name": "Riean_0653-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064357": {"description": "Peptidyl-Asp metalloendopeptidase", "go_ids": [], "go_terms": [], "name": "Mep72", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064358": {"description": "Biofilm-associated metzincin protease inhibitor", "go_ids": [], "go_terms": [], "name": "BamI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064359": {"description": "Methylphosphonate hydroxylase", "go_ids": [], "go_terms": [], "name": "PhnY", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064360": {"description": "HTH-type transcriptional regulator MT0903-like, mycobacteriales", "go_ids": [], "go_terms": [], "name": "MT0903_mycobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064361": {"description": "Prodigiosin ligase PigC", "go_ids": [], "go_terms": [], "name": "Prodigiosin_PigC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064362": {"description": "Mannosyltransferase MT1671", "go_ids": [], "go_terms": [], "name": "MT1671", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064363": {"description": "Hydroxymethylphosphonate dioxygenase, planctomycetia", "go_ids": [], "go_terms": [], "name": "PhnZ1", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064364": {"description": "Radical copper oxidase GlxA", "go_ids": [], "go_terms": [], "name": "GlxA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064365": {"description": "HTH-type transcriptional regulator Rv0792c", "go_ids": [], "go_terms": [], "name": "Rv0792c", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064366": {"description": "Sensor histidine kinase MctS, hyphomicrobiales", "go_ids": [], "go_terms": [], "name": "MctS_hyphomicrobiales", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064367": {"description": "Transcriptional regulatory protein MctR", "go_ids": [], "go_terms": [], "name": "MctR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064368": {"description": "PA3715-like, putative", "go_ids": [], "go_terms": [], "name": "PA3715_putative", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064369": {"description": "Secreted effector lipase Rlip", "go_ids": [], "go_terms": [], "name": "Rlip_lipase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064370": {"description": "VC1380-like", "go_ids": [], "go_terms": [], "name": "VC138-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064371": {"description": "SrfG family effector protein", "go_ids": [], "go_terms": [], "name": "SrfG_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064372": {"description": "Methanethiol oxidase, pseudomonadota", "go_ids": [], "go_terms": [], "name": "MtoX_pseudo", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064373": {"description": "SrfF family effector protein", "go_ids": [], "go_terms": [], "name": "SrfF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064374": {"description": "SrfC family effector protein", "go_ids": [], "go_terms": [], "name": "SrfC_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064375": {"description": "Biofilm-associated protein VP0952", "go_ids": [], "go_terms": [], "name": "VP0952-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064376": {"description": "Endo-1,3-1,4-beta-glycanase EglC/ExsH", "go_ids": [], "go_terms": [], "name": "EglC/ExsH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064377": {"description": "Npun_F2552 family protein", "go_ids": [], "go_terms": [], "name": "Npun_F2552_fam", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064378": {"description": "Surface cell antigen Sca2", "go_ids": [], "go_terms": [], "name": "Rick_Sca2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064379": {"description": "AP-4-A phosphorylase, Mycobacteriales", "go_ids": [], "go_terms": [], "name": "AP4A_Mycobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064380": {"description": "Manganese efflux transporter MntE", "go_ids": [], "go_terms": [], "name": "MntE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064381": {"description": "Lp_1002 arylesterase", "go_ids": [], "go_terms": [], "name": "AryltfaseLP1002", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064382": {"description": "Chitinase ChiD", "go_ids": [], "go_terms": [], "name": "ChiD", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064383": {"description": "Bifunctional ornithine lipid synthase OlsF", "go_ids": [], "go_terms": [], "name": "OlsF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064384": {"description": "Slr0373 blue light stress response protein", "go_ids": [], "go_terms": [], "name": "Slr0373_blue", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064385": {"description": "Lyso-ornithine lipid synthetase OlsH", "go_ids": [], "go_terms": [], "name": "OlsH_GH3_orni", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064386": {"description": "Ornithine lipid biosynthesis O-acyltransferase OlsI", "go_ids": [], "go_terms": [], "name": "AB_fold_OlsI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064387": {"description": "Trehalose monomycolate exporter MmpL3", "go_ids": [], "go_terms": [], "name": "MmpL3", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064388": {"description": "Sll1863-like stress response domain", "go_ids": [], "go_terms": [], "name": "Sll1863_dom", "pathway_ids": [], "pathways": [], "type": "Domain"}, "IPR064389": {"description": "Putative T3SS effector CT656", "go_ids": [], "go_terms": [], "name": "T3SS_eff_CT656", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064390": {"description": "PA5033 protein", "go_ids": [], "go_terms": [], "name": "PA5033-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064391": {"description": "Methyl-plastoquinone biosynthesis methyltransferase MpqE", "go_ids": [], "go_terms": [], "name": "MpqE", "pathway_ids": 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PagR", "go_ids": [], "go_terms": [], "name": "PagR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064415": {"description": "Alr5209 family pentapeptide repeat protein", "go_ids": [], "go_terms": [], "name": "Penta_Alr5209", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064416": {"description": "Alpha-ketoglutarate semialdehyde dehydrogenase", "go_ids": [], "go_terms": [], "name": "KGSADH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064417": {"description": "Outer surface protein C, Borreliaceae", "go_ids": [], "go_terms": [], "name": "OspC", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064418": {"description": "CDF family zinc efflux transporter Cdf31", "go_ids": [], "go_terms": [], "name": "Zn_efflux_Cdf31", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064419": {"description": "Rv2253-like sensor-like surface protein", "go_ids": [], "go_terms": [], "name": "Rv2253-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064420": {"description": "Undecaprenyl-phosphate galactose phosphotransferase", "go_ids": [], "go_terms": [], "name": "RfbP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064421": {"description": "ECs1377-like", "go_ids": [], "go_terms": [], "name": "ECs1377-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064422": {"description": "Response regulator cyclic di-GMP phosphodiesterase PvrR", "go_ids": [], "go_terms": [], "name": "PvrR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064423": {"description": "VV20781-like", "go_ids": [], "go_terms": [], "name": "VV20781-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064424": {"description": "Transcriptional activator RhrA", "go_ids": [], "go_terms": [], "name": "RhrA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064425": {"description": "3-sulfopropionylcysteine synthase XcbD", "go_ids": [], "go_terms": [], "name": "XcbD", "pathway_ids": [], "pathways": 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"Lyso-ornithine lipid O-acyltransferase", "go_ids": [], "go_terms": [], "name": "OlsA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064432": {"description": "Coenzyme M biosynthesis enzyme XcbE", "go_ids": [], "go_terms": [], "name": "XcbE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064433": {"description": "XcbA protein", "go_ids": [], "go_terms": [], "name": "XcbA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064434": {"description": "Divisome-associated lipoprotein DalA", "go_ids": [], "go_terms": [], "name": "DalA", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064435": {"description": "Cyclo(L-tyrosyl-L-tyrosyl) synthase", "go_ids": [], "go_terms": [], "name": "CDPS_Tyr", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064436": {"description": "Putative transporter subunit Mul1B", "go_ids": [], "go_terms": [], "name": "Mul1B", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064437": {"description": "Phospholipase BipL", "go_ids": [], "go_terms": [], "name": "BipL", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064438": {"description": "Alpha-arabinofuranosidase", "go_ids": [], "go_terms": [], "name": "Alpha-arabino", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064439": {"description": "N-acyl-d-glucosamine 2-epimerase BoAGE2", "go_ids": [], "go_terms": [], "name": "BoAGE2", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064440": {"description": "Lyso-ornithine lipid O-acyltransferase, Rhodobacterales", "go_ids": [], "go_terms": [], "name": "OlsA_rhodobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064441": {"description": "Lipoprotein LpqN", "go_ids": [], "go_terms": [], "name": "LpqN", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064442": {"description": "Beta-1,2-mannobiose phosphorylase", "go_ids": [], "go_terms": [], "name": "BManbPhaseBMBP", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064443": {"description": "Teichoic acid biosynthesis protein TarQ", "go_ids": [], "go_terms": [], "name": "Teichoic_TarQ", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064444": {"description": "Nickel-dependent malate racemase, LarAH5-like", "go_ids": [], "go_terms": [], "name": "NPN_LarAH5_MAR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064445": {"description": "Nickel-dependent putative hexonate epimerase, LarAH18-like", "go_ids": [], "go_terms": [], "name": "NPN_18_hexonate", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064446": {"description": "Nickel-dependent malate racemase, LarAH6-like", "go_ids": [], "go_terms": [], "name": "NPN_racem_MAR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064447": {"description": "Archaellum stator protein ArlG", "go_ids": [], "go_terms": [], "name": "ArlG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064448": {"description": "Archaellum stator protein ArlF", "go_ids": [], "go_terms": [], "name": "ArlF", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064449": {"description": "Archaellum protein ArlH", "go_ids": [], "go_terms": [], "name": "ArlH", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064450": {"description": "Ribonuclease E, mycobacterium", "go_ids": [], "go_terms": [], "name": "RnaseE_mycob", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064451": {"description": "Steroid-22-oyl-CoA synthetase", "go_ids": [], "go_terms": [], "name": "SterCoASynCasI", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064452": {"description": "Ribonuclease E, cyanobacteria", "go_ids": ["GO:0000049", "GO:0004519", "GO:0004540", "GO:0019843", "GO:0008033", "GO:0006364"], "go_terms": ["GO:0000049:tRNA binding:F", "GO:0004519:endonuclease activity:F", "GO:0004540:RNA nuclease activity:F", "GO:0019843:rRNA binding:F", "GO:0008033:tRNA processing:P", "GO:0006364:rRNA processing:P"], "name": "RnaseE_cyano", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064453": {"description": "Steroid-24-oyl-CoA synthetase", "go_ids": ["GO:0047747", "GO:0031956", "GO:0008202"], "go_terms": ["GO:0047747:cholate-CoA ligase activity:F", "GO:0031956:medium-chain fatty acid-CoA ligase activity:F", "GO:0008202:steroid metabolic process:P"], "name": "Str24CoAsynCasG", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064454": {"description": "Thiosulfate transporter TsuA, thermotogae-type", "go_ids": [], "go_terms": [], "name": "TsuA_thermotogae-type", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064455": {"description": "Sterol demethylase protein B", "go_ids": [], "go_terms": [], "name": "StrlDmthSdmBMthl", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064456": {"description": "4beta-methylsterol monooxygenase", "go_ids": ["GO:0004497", "GO:0016126"], "go_terms": ["GO:0004497:monooxygenase activity:F", "GO:0016126:sterol biosynthetic process:P"], "name": "BetMthstMoxSdmAMthl", "pathway_ids": [], 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"Family"}, "IPR064478": {"description": "Alkanal monooxygenase beta chain", "go_ids": [], "go_terms": [], "name": "LuxB", "pathway_ids": ["PWY-7723"], "pathways": ["PWY-7723:t:bacterial bioluminescence"], "type": "Family"}, "IPR064479": {"description": "Envelope protein P10", "go_ids": [], "go_terms": [], "name": "Phage_P10", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064480": {"description": "Long-chain-fatty-acid--CoA ligase FadD-like, bacilli", "go_ids": [], "go_terms": [], "name": "FadD-like_bacilli", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064481": {"description": "Fatty acid degradation protein FadX", "go_ids": [], "go_terms": [], "name": "FadX", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064482": {"description": "3-hydroxyacyl-CoA dehydrogenase/crotonase FadB, Staphylococcus", "go_ids": [], "go_terms": [], "name": "FadB_staph", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064483": {"description": "BB0569-like chemotaxis protein", "go_ids": [], "go_terms": [], "name": "BB0569-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064484": {"description": "CT529-like inclusion membrane protein", "go_ids": [], "go_terms": [], "name": "CT529-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064485": {"description": "7-bladed beta-propeller protein YncE", "go_ids": [], "go_terms": [], "name": "YncE", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064486": {"description": "Rhizopine catabolism transcriptional regulator MocR", "go_ids": [], "go_terms": [], "name": "MocR", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064487": {"description": "Endonuclease dU, halobacteria", "go_ids": [], "go_terms": [], "name": "Du_halobact", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064488": {"description": "MocR-like transcriptional regulator GabR", "go_ids": [], "go_terms": [], "name": "GabR", "pathway_ids": [], "pathways": [], "type": "Family"}, 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synthase", "go_ids": [], "go_terms": [], "name": "Delta_Cadinene_Synthase", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064495": {"description": "Beta-lactamase OXA-20", "go_ids": [], "go_terms": [], "name": "Beta_lactamase_OXA-20-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064496": {"description": "CT360-like", "go_ids": [], "go_terms": [], "name": "CT360-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064497": {"description": "Rv1419-like lectin", "go_ids": [], "go_terms": [], "name": "Rv1419-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064498": {"description": "XAC0231-like", "go_ids": [], "go_terms": [], "name": "XAC0231-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064499": {"description": "Lmo2079-like surface lipoprotein", "go_ids": [], "go_terms": [], "name": "Lmo2079-like", "pathway_ids": [], "pathways": [], "type": "Family"}, "IPR064500": {"description": "Major fimbrium tip subunit 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